id sid tid token lemma pos cord-345222-otfnrarh 1 1 key key NN cord-345222-otfnrarh 1 2 : : : cord-345222-otfnrarh 1 3 cord-345222-otfnrarh cord-345222-otfnrarh . cord-345222-otfnrarh 2 1 authors author NNS cord-345222-otfnrarh 2 2 : : : cord-345222-otfnrarh 2 3 Ciccarelli Ciccarelli NNP cord-345222-otfnrarh 2 4 , , , cord-345222-otfnrarh 2 5 Simona Simona NNP cord-345222-otfnrarh 2 6 ; ; : cord-345222-otfnrarh 2 7 Stolfi Stolfi NNP cord-345222-otfnrarh 2 8 , , , cord-345222-otfnrarh 2 9 Ilaria Ilaria NNP cord-345222-otfnrarh 2 10 ; ; : cord-345222-otfnrarh 2 11 Caramia Caramia NNP cord-345222-otfnrarh 2 12 , , , cord-345222-otfnrarh 2 13 Giuseppe Giuseppe NNP cord-345222-otfnrarh 2 14 title title NN cord-345222-otfnrarh 2 15 : : : cord-345222-otfnrarh 3 1 Management management NN cord-345222-otfnrarh 3 2 strategies strategy NNS cord-345222-otfnrarh 3 3 in in IN cord-345222-otfnrarh 3 4 the the DT cord-345222-otfnrarh 3 5 treatment treatment NN cord-345222-otfnrarh 3 6 of of IN cord-345222-otfnrarh 3 7 neonatal neonatal JJ cord-345222-otfnrarh 3 8 and and CC cord-345222-otfnrarh 3 9 pediatric pediatric JJ cord-345222-otfnrarh 3 10 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 3 11 date date NN cord-345222-otfnrarh 3 12 : : : cord-345222-otfnrarh 3 13 2013 2013 CD cord-345222-otfnrarh 3 14 - - SYM cord-345222-otfnrarh 3 15 10 10 CD cord-345222-otfnrarh 3 16 - - SYM cord-345222-otfnrarh 3 17 29 29 CD cord-345222-otfnrarh 3 18 journal journal NN cord-345222-otfnrarh 3 19 : : : cord-345222-otfnrarh 4 1 Infect infect VB cord-345222-otfnrarh 4 2 Drug drug NN cord-345222-otfnrarh 4 3 Resist resist NN cord-345222-otfnrarh 4 4 DOI doi NN cord-345222-otfnrarh 5 1 : : : cord-345222-otfnrarh 5 2 10.2147 10.2147 CD cord-345222-otfnrarh 5 3 / / NFP cord-345222-otfnrarh 5 4 idr.s12718 idr.s12718 NNP cord-345222-otfnrarh 5 5 sha sha NNP cord-345222-otfnrarh 5 6 : : : cord-345222-otfnrarh 6 1 f1382d2d476137ce89455675b6a2eb68a485ebac f1382d2d476137ce89455675b6a2eb68a485ebac NNP cord-345222-otfnrarh 6 2 doc_id doc_id CD cord-345222-otfnrarh 7 1 : : : cord-345222-otfnrarh 7 2 345222 345222 CD cord-345222-otfnrarh 7 3 cord_uid cord_uid NN cord-345222-otfnrarh 7 4 : : : cord-345222-otfnrarh 8 1 otfnrarh otfnrarh NNP cord-345222-otfnrarh 8 2 Acute acute JJ cord-345222-otfnrarh 8 3 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 8 4 , , , cord-345222-otfnrarh 8 5 characterized characterize VBN cord-345222-otfnrarh 8 6 by by IN cord-345222-otfnrarh 8 7 the the DT cord-345222-otfnrarh 8 8 onset onset NN cord-345222-otfnrarh 8 9 of of IN cord-345222-otfnrarh 8 10 diarrhea diarrhea NN cord-345222-otfnrarh 8 11 with with IN cord-345222-otfnrarh 8 12 or or CC cord-345222-otfnrarh 8 13 without without IN cord-345222-otfnrarh 8 14 vomiting vomit VBG cord-345222-otfnrarh 8 15 , , , cord-345222-otfnrarh 8 16 continues continue VBZ cord-345222-otfnrarh 8 17 to to TO cord-345222-otfnrarh 8 18 be be VB cord-345222-otfnrarh 8 19 a a DT cord-345222-otfnrarh 8 20 major major JJ cord-345222-otfnrarh 8 21 cause cause NN cord-345222-otfnrarh 8 22 of of IN cord-345222-otfnrarh 8 23 morbidity morbidity NN cord-345222-otfnrarh 8 24 and and CC cord-345222-otfnrarh 8 25 mortality mortality NN cord-345222-otfnrarh 8 26 in in IN cord-345222-otfnrarh 8 27 children child NNS cord-345222-otfnrarh 8 28 in in IN cord-345222-otfnrarh 8 29 mostly mostly RB cord-345222-otfnrarh 8 30 resource resource NN cord-345222-otfnrarh 8 31 - - HYPH cord-345222-otfnrarh 8 32 constrained constrain VBN cord-345222-otfnrarh 8 33 nations nation NNS cord-345222-otfnrarh 8 34 . . . cord-345222-otfnrarh 9 1 Although although IN cord-345222-otfnrarh 9 2 generally generally RB cord-345222-otfnrarh 9 3 a a DT cord-345222-otfnrarh 9 4 mild mild JJ cord-345222-otfnrarh 9 5 and and CC cord-345222-otfnrarh 9 6 self self NN cord-345222-otfnrarh 9 7 - - HYPH cord-345222-otfnrarh 9 8 limiting limit VBG cord-345222-otfnrarh 9 9 disease disease NN cord-345222-otfnrarh 9 10 , , , cord-345222-otfnrarh 9 11 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 9 12 is be VBZ cord-345222-otfnrarh 9 13 one one CD cord-345222-otfnrarh 9 14 of of IN cord-345222-otfnrarh 9 15 the the DT cord-345222-otfnrarh 9 16 most most RBS cord-345222-otfnrarh 9 17 common common JJ cord-345222-otfnrarh 9 18 causes cause NNS cord-345222-otfnrarh 9 19 of of IN cord-345222-otfnrarh 9 20 hospitalization hospitalization NN cord-345222-otfnrarh 9 21 and and CC cord-345222-otfnrarh 9 22 is be VBZ cord-345222-otfnrarh 9 23 associated associate VBN cord-345222-otfnrarh 9 24 with with IN cord-345222-otfnrarh 9 25 a a DT cord-345222-otfnrarh 9 26 substantial substantial JJ cord-345222-otfnrarh 9 27 disease disease NN cord-345222-otfnrarh 9 28 burden burden NN cord-345222-otfnrarh 9 29 . . . cord-345222-otfnrarh 10 1 Worldwide worldwide RB cord-345222-otfnrarh 10 2 , , , cord-345222-otfnrarh 10 3 up up IN cord-345222-otfnrarh 10 4 to to TO cord-345222-otfnrarh 10 5 40 40 CD cord-345222-otfnrarh 10 6 % % NN cord-345222-otfnrarh 10 7 of of IN cord-345222-otfnrarh 10 8 children child NNS cord-345222-otfnrarh 10 9 aged age VBN cord-345222-otfnrarh 10 10 less less JJR cord-345222-otfnrarh 10 11 than than IN cord-345222-otfnrarh 10 12 5 5 CD cord-345222-otfnrarh 10 13 years year NNS cord-345222-otfnrarh 10 14 with with IN cord-345222-otfnrarh 10 15 diarrhea diarrhea NN cord-345222-otfnrarh 10 16 are be VBP cord-345222-otfnrarh 10 17 hospitalized hospitalize VBN cord-345222-otfnrarh 10 18 with with IN cord-345222-otfnrarh 10 19 rotavirus rotavirus NN cord-345222-otfnrarh 10 20 . . . cord-345222-otfnrarh 11 1 Also also RB cord-345222-otfnrarh 11 2 , , , cord-345222-otfnrarh 11 3 some some DT cord-345222-otfnrarh 11 4 microorganisms microorganism NNS cord-345222-otfnrarh 11 5 have have VBP cord-345222-otfnrarh 11 6 been be VBN cord-345222-otfnrarh 11 7 found find VBN cord-345222-otfnrarh 11 8 predominantly predominantly RB cord-345222-otfnrarh 11 9 in in IN cord-345222-otfnrarh 11 10 resource resource NN cord-345222-otfnrarh 11 11 - - HYPH cord-345222-otfnrarh 11 12 constrained constrain VBN cord-345222-otfnrarh 11 13 nations nation NNS cord-345222-otfnrarh 11 14 , , , cord-345222-otfnrarh 11 15 including include VBG cord-345222-otfnrarh 11 16 Shigella Shigella NNP cord-345222-otfnrarh 11 17 spp spp NNS cord-345222-otfnrarh 11 18 , , , cord-345222-otfnrarh 11 19 Vibrio Vibrio NNP cord-345222-otfnrarh 11 20 cholerae cholerae NN cord-345222-otfnrarh 11 21 , , , cord-345222-otfnrarh 11 22 and and CC cord-345222-otfnrarh 11 23 the the DT cord-345222-otfnrarh 11 24 protozoan protozoan NN cord-345222-otfnrarh 11 25 infections infection NNS cord-345222-otfnrarh 11 26 . . . cord-345222-otfnrarh 12 1 Prevention prevention NN cord-345222-otfnrarh 12 2 remains remain VBZ cord-345222-otfnrarh 12 3 essential essential JJ cord-345222-otfnrarh 12 4 , , , cord-345222-otfnrarh 12 5 and and CC cord-345222-otfnrarh 12 6 the the DT cord-345222-otfnrarh 12 7 rotavirus rotavirus JJ cord-345222-otfnrarh 12 8 vaccines vaccine NNS cord-345222-otfnrarh 12 9 have have VBP cord-345222-otfnrarh 12 10 demonstrated demonstrate VBN cord-345222-otfnrarh 12 11 good good JJ cord-345222-otfnrarh 12 12 safety safety NN cord-345222-otfnrarh 12 13 and and CC cord-345222-otfnrarh 12 14 efficacy efficacy NN cord-345222-otfnrarh 12 15 profiles profile NNS cord-345222-otfnrarh 12 16 in in IN cord-345222-otfnrarh 12 17 large large JJ cord-345222-otfnrarh 12 18 clinical clinical JJ cord-345222-otfnrarh 12 19 trials trial NNS cord-345222-otfnrarh 12 20 . . . cord-345222-otfnrarh 13 1 Because because IN cord-345222-otfnrarh 13 2 dehydration dehydration NN cord-345222-otfnrarh 13 3 is be VBZ cord-345222-otfnrarh 13 4 the the DT cord-345222-otfnrarh 13 5 major major JJ cord-345222-otfnrarh 13 6 complication complication NN cord-345222-otfnrarh 13 7 associated associate VBN cord-345222-otfnrarh 13 8 with with IN cord-345222-otfnrarh 13 9 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 13 10 , , , cord-345222-otfnrarh 13 11 appropriate appropriate JJ cord-345222-otfnrarh 13 12 fluid fluid JJ cord-345222-otfnrarh 13 13 management management NN cord-345222-otfnrarh 13 14 ( ( -LRB- cord-345222-otfnrarh 13 15 oral oral JJ cord-345222-otfnrarh 13 16 or or CC cord-345222-otfnrarh 13 17 intravenous intravenous JJ cord-345222-otfnrarh 13 18 ) ) -RRB- cord-345222-otfnrarh 13 19 is be VBZ cord-345222-otfnrarh 13 20 an an DT cord-345222-otfnrarh 13 21 effective effective JJ cord-345222-otfnrarh 13 22 and and CC cord-345222-otfnrarh 13 23 safe safe JJ cord-345222-otfnrarh 13 24 strategy strategy NN cord-345222-otfnrarh 13 25 for for IN cord-345222-otfnrarh 13 26 rehydration rehydration NN cord-345222-otfnrarh 13 27 . . . cord-345222-otfnrarh 14 1 Continuation continuation NN cord-345222-otfnrarh 14 2 of of IN cord-345222-otfnrarh 14 3 breastfeeding breastfeeding NN cord-345222-otfnrarh 14 4 is be VBZ cord-345222-otfnrarh 14 5 strongly strongly RB cord-345222-otfnrarh 14 6 recommended recommend VBN cord-345222-otfnrarh 14 7 . . . cord-345222-otfnrarh 15 1 New new JJ cord-345222-otfnrarh 15 2 treatments treatment NNS cord-345222-otfnrarh 15 3 such such JJ cord-345222-otfnrarh 15 4 as as IN cord-345222-otfnrarh 15 5 antiemetics antiemetic NNS cord-345222-otfnrarh 15 6 ( ( -LRB- cord-345222-otfnrarh 15 7 ondansetron ondansetron NN cord-345222-otfnrarh 15 8 ) ) -RRB- cord-345222-otfnrarh 15 9 , , , cord-345222-otfnrarh 15 10 some some DT cord-345222-otfnrarh 15 11 antidiarrheal antidiarrheal JJ cord-345222-otfnrarh 15 12 agents agent NNS cord-345222-otfnrarh 15 13 ( ( -LRB- cord-345222-otfnrarh 15 14 racecadotril racecadotril NNP cord-345222-otfnrarh 15 15 ) ) -RRB- cord-345222-otfnrarh 15 16 , , , cord-345222-otfnrarh 15 17 and and CC cord-345222-otfnrarh 15 18 chemotherapeutic chemotherapeutic JJ cord-345222-otfnrarh 15 19 agents agent NNS cord-345222-otfnrarh 15 20 are be VBP cord-345222-otfnrarh 15 21 often often RB cord-345222-otfnrarh 15 22 proposed propose VBN cord-345222-otfnrarh 15 23 , , , cord-345222-otfnrarh 15 24 but but CC cord-345222-otfnrarh 15 25 not not RB cord-345222-otfnrarh 15 26 yet yet RB cord-345222-otfnrarh 15 27 universally universally RB cord-345222-otfnrarh 15 28 recommended recommend VBN cord-345222-otfnrarh 15 29 . . . cord-345222-otfnrarh 16 1 Probiotics probiotic NNS cord-345222-otfnrarh 16 2 , , , cord-345222-otfnrarh 16 3 also also RB cord-345222-otfnrarh 16 4 known know VBN cord-345222-otfnrarh 16 5 as as IN cord-345222-otfnrarh 16 6 “ " `` cord-345222-otfnrarh 16 7 food food NN cord-345222-otfnrarh 16 8 supplement supplement NN cord-345222-otfnrarh 16 9 , , , cord-345222-otfnrarh 16 10 ” " '' cord-345222-otfnrarh 16 11 seem seem VBP cord-345222-otfnrarh 16 12 to to TO cord-345222-otfnrarh 16 13 improve improve VB cord-345222-otfnrarh 16 14 intestinal intestinal JJ cord-345222-otfnrarh 16 15 microbial microbial JJ cord-345222-otfnrarh 16 16 balance balance NN cord-345222-otfnrarh 16 17 , , , cord-345222-otfnrarh 16 18 reducing reduce VBG cord-345222-otfnrarh 16 19 the the DT cord-345222-otfnrarh 16 20 duration duration NN cord-345222-otfnrarh 16 21 and and CC cord-345222-otfnrarh 16 22 the the DT cord-345222-otfnrarh 16 23 severity severity NN cord-345222-otfnrarh 16 24 of of IN cord-345222-otfnrarh 16 25 acute acute JJ cord-345222-otfnrarh 16 26 infectious infectious JJ cord-345222-otfnrarh 16 27 diarrhea diarrhea NN cord-345222-otfnrarh 16 28 . . . cord-345222-otfnrarh 17 1 The the DT cord-345222-otfnrarh 17 2 European European NNP cord-345222-otfnrarh 17 3 Society Society NNP cord-345222-otfnrarh 17 4 for for IN cord-345222-otfnrarh 17 5 Paediatric Paediatric NNP cord-345222-otfnrarh 17 6 Gastroenterology Gastroenterology NNP cord-345222-otfnrarh 17 7 , , , cord-345222-otfnrarh 17 8 Hepatology Hepatology NNP cord-345222-otfnrarh 17 9 and and CC cord-345222-otfnrarh 17 10 Nutrition Nutrition NNP cord-345222-otfnrarh 17 11 and and CC cord-345222-otfnrarh 17 12 the the DT cord-345222-otfnrarh 17 13 European European NNP cord-345222-otfnrarh 17 14 Society Society NNP cord-345222-otfnrarh 17 15 of of IN cord-345222-otfnrarh 17 16 Paediatric Paediatric NNP cord-345222-otfnrarh 17 17 Infectious Infectious NNP cord-345222-otfnrarh 17 18 Diseases Diseases NNPS cord-345222-otfnrarh 17 19 guidelines guideline NNS cord-345222-otfnrarh 17 20 make make VBP cord-345222-otfnrarh 17 21 a a DT cord-345222-otfnrarh 17 22 stronger strong JJR cord-345222-otfnrarh 17 23 recommendation recommendation NN cord-345222-otfnrarh 17 24 for for IN cord-345222-otfnrarh 17 25 the the DT cord-345222-otfnrarh 17 26 use use NN cord-345222-otfnrarh 17 27 of of IN cord-345222-otfnrarh 17 28 probiotics probiotic NNS cord-345222-otfnrarh 17 29 for for IN cord-345222-otfnrarh 17 30 the the DT cord-345222-otfnrarh 17 31 management management NN cord-345222-otfnrarh 17 32 of of IN cord-345222-otfnrarh 17 33 acute acute JJ cord-345222-otfnrarh 17 34 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 17 35 , , , cord-345222-otfnrarh 17 36 particularly particularly RB cord-345222-otfnrarh 17 37 those those DT cord-345222-otfnrarh 17 38 with with IN cord-345222-otfnrarh 17 39 documented document VBN cord-345222-otfnrarh 17 40 efficacy efficacy NN cord-345222-otfnrarh 17 41 such such JJ cord-345222-otfnrarh 17 42 as as IN cord-345222-otfnrarh 17 43 Lactobacillus lactobacillus NN cord-345222-otfnrarh 17 44 rhamnosus rhamnosus NN cord-345222-otfnrarh 17 45 GG GG NNP cord-345222-otfnrarh 17 46 , , , cord-345222-otfnrarh 17 47 Lactobacillus lactobacillus NN cord-345222-otfnrarh 17 48 reuteri reuteri NN cord-345222-otfnrarh 17 49 , , , cord-345222-otfnrarh 17 50 and and CC cord-345222-otfnrarh 17 51 Saccharomyces Saccharomyces NNP cord-345222-otfnrarh 17 52 boulardii boulardii XX cord-345222-otfnrarh 17 53 . . . cord-345222-otfnrarh 18 1 To to IN cord-345222-otfnrarh 18 2 date date NN cord-345222-otfnrarh 18 3 , , , cord-345222-otfnrarh 18 4 the the DT cord-345222-otfnrarh 18 5 management management NN cord-345222-otfnrarh 18 6 of of IN cord-345222-otfnrarh 18 7 acute acute JJ cord-345222-otfnrarh 18 8 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 18 9 has have VBZ cord-345222-otfnrarh 18 10 been be VBN cord-345222-otfnrarh 18 11 based base VBN cord-345222-otfnrarh 18 12 on on IN cord-345222-otfnrarh 18 13 the the DT cord-345222-otfnrarh 18 14 option option NN cord-345222-otfnrarh 18 15 of of IN cord-345222-otfnrarh 18 16 “ " `` cord-345222-otfnrarh 18 17 doing do VBG cord-345222-otfnrarh 18 18 the the DT cord-345222-otfnrarh 18 19 least least JJS cord-345222-otfnrarh 18 20 ” " '' cord-345222-otfnrarh 18 21 : : : cord-345222-otfnrarh 18 22 oral oral JJ cord-345222-otfnrarh 18 23 rehydration rehydration NN cord-345222-otfnrarh 18 24 - - HYPH cord-345222-otfnrarh 18 25 solution solution NN cord-345222-otfnrarh 18 26 administration administration NN cord-345222-otfnrarh 18 27 , , , cord-345222-otfnrarh 18 28 early early JJ cord-345222-otfnrarh 18 29 refeeding refeeding NN cord-345222-otfnrarh 18 30 , , , cord-345222-otfnrarh 18 31 no no DT cord-345222-otfnrarh 18 32 testing testing NN cord-345222-otfnrarh 18 33 , , , cord-345222-otfnrarh 18 34 no no DT cord-345222-otfnrarh 18 35 unnecessary unnecessary JJ cord-345222-otfnrarh 18 36 drugs drug NNS cord-345222-otfnrarh 18 37 . . . cord-345222-otfnrarh 19 1 Acute acute JJ cord-345222-otfnrarh 19 2 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 19 3 ( ( -LRB- cord-345222-otfnrarh 19 4 AGE AGE NNP cord-345222-otfnrarh 19 5 ) ) -RRB- cord-345222-otfnrarh 19 6 , , , cord-345222-otfnrarh 19 7 characterized characterize VBN cord-345222-otfnrarh 19 8 by by IN cord-345222-otfnrarh 19 9 the the DT cord-345222-otfnrarh 19 10 onset onset NN cord-345222-otfnrarh 19 11 of of IN cord-345222-otfnrarh 19 12 diarrhea diarrhea NN cord-345222-otfnrarh 19 13 with with IN cord-345222-otfnrarh 19 14 or or CC cord-345222-otfnrarh 19 15 without without IN cord-345222-otfnrarh 19 16 vomiting vomit VBG cord-345222-otfnrarh 19 17 , , , cord-345222-otfnrarh 19 18 continues continue VBZ cord-345222-otfnrarh 19 19 to to TO cord-345222-otfnrarh 19 20 be be VB cord-345222-otfnrarh 19 21 a a DT cord-345222-otfnrarh 19 22 major major JJ cord-345222-otfnrarh 19 23 cause cause NN cord-345222-otfnrarh 19 24 of of IN cord-345222-otfnrarh 19 25 morbidity morbidity NN cord-345222-otfnrarh 19 26 and and CC cord-345222-otfnrarh 19 27 mortality mortality NN cord-345222-otfnrarh 19 28 in in IN cord-345222-otfnrarh 19 29 children child NNS cord-345222-otfnrarh 19 30 mostly mostly RB cord-345222-otfnrarh 19 31 in in IN cord-345222-otfnrarh 19 32 resource resource NN cord-345222-otfnrarh 19 33 - - HYPH cord-345222-otfnrarh 19 34 constrained constrain VBN cord-345222-otfnrarh 19 35 nations nation NNS cord-345222-otfnrarh 19 36 . . . cord-345222-otfnrarh 20 1 Although although IN cord-345222-otfnrarh 20 2 generally generally RB cord-345222-otfnrarh 20 3 it -PRON- PRP cord-345222-otfnrarh 20 4 is be VBZ cord-345222-otfnrarh 20 5 a a DT cord-345222-otfnrarh 20 6 mild mild JJ cord-345222-otfnrarh 20 7 and and CC cord-345222-otfnrarh 20 8 self self NN cord-345222-otfnrarh 20 9 - - HYPH cord-345222-otfnrarh 20 10 limiting limit VBG cord-345222-otfnrarh 20 11 disease disease NN cord-345222-otfnrarh 20 12 , , , cord-345222-otfnrarh 20 13 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 20 14 is be VBZ cord-345222-otfnrarh 20 15 one one CD cord-345222-otfnrarh 20 16 of of IN cord-345222-otfnrarh 20 17 the the DT cord-345222-otfnrarh 20 18 most most RBS cord-345222-otfnrarh 20 19 common common JJ cord-345222-otfnrarh 20 20 causes cause NNS cord-345222-otfnrarh 20 21 of of IN cord-345222-otfnrarh 20 22 hospitalization hospitalization NN cord-345222-otfnrarh 20 23 and and CC cord-345222-otfnrarh 20 24 is be VBZ cord-345222-otfnrarh 20 25 associated associate VBN cord-345222-otfnrarh 20 26 with with IN cord-345222-otfnrarh 20 27 a a DT cord-345222-otfnrarh 20 28 substantial substantial JJ cord-345222-otfnrarh 20 29 disease disease NN cord-345222-otfnrarh 20 30 burden burden NN cord-345222-otfnrarh 20 31 . . . cord-345222-otfnrarh 21 1 1 1 CD cord-345222-otfnrarh 21 2 , , , cord-345222-otfnrarh 21 3 2 2 CD cord-345222-otfnrarh 22 1 According accord VBG cord-345222-otfnrarh 22 2 to to IN cord-345222-otfnrarh 22 3 the the DT cord-345222-otfnrarh 22 4 World World NNP cord-345222-otfnrarh 22 5 Health Health NNP cord-345222-otfnrarh 22 6 Organization Organization NNP cord-345222-otfnrarh 22 7 ( ( -LRB- cord-345222-otfnrarh 22 8 WHO who WP cord-345222-otfnrarh 22 9 ) ) -RRB- cord-345222-otfnrarh 22 10 , , , cord-345222-otfnrarh 22 11 diarrhea diarrhea NN cord-345222-otfnrarh 22 12 is be VBZ cord-345222-otfnrarh 22 13 defined define VBN cord-345222-otfnrarh 22 14 as as IN cord-345222-otfnrarh 22 15 the the DT cord-345222-otfnrarh 22 16 passage passage NN cord-345222-otfnrarh 22 17 of of IN cord-345222-otfnrarh 22 18 three three CD cord-345222-otfnrarh 22 19 or or CC cord-345222-otfnrarh 22 20 more more RBR cord-345222-otfnrarh 22 21 loose loose JJ cord-345222-otfnrarh 22 22 or or CC cord-345222-otfnrarh 22 23 liquid liquid JJ cord-345222-otfnrarh 22 24 stools stool NNS cord-345222-otfnrarh 22 25 per per IN cord-345222-otfnrarh 22 26 day day NN cord-345222-otfnrarh 22 27 , , , cord-345222-otfnrarh 22 28 or or CC cord-345222-otfnrarh 22 29 more more RBR cord-345222-otfnrarh 22 30 frequently frequently RB cord-345222-otfnrarh 22 31 than than IN cord-345222-otfnrarh 22 32 is be VBZ cord-345222-otfnrarh 22 33 normal normal JJ cord-345222-otfnrarh 22 34 for for IN cord-345222-otfnrarh 22 35 the the DT cord-345222-otfnrarh 22 36 individual individual NN cord-345222-otfnrarh 22 37 . . . cord-345222-otfnrarh 23 1 3 3 LS cord-345222-otfnrarh 24 1 When when WRB cord-345222-otfnrarh 24 2 young young JJ cord-345222-otfnrarh 24 3 children child NNS cord-345222-otfnrarh 24 4 suddenly suddenly RB cord-345222-otfnrarh 24 5 experience experience VBP cord-345222-otfnrarh 24 6 an an DT cord-345222-otfnrarh 24 7 episode episode NN cord-345222-otfnrarh 24 8 of of IN cord-345222-otfnrarh 24 9 acute acute JJ cord-345222-otfnrarh 24 10 diarrhea diarrhea NN cord-345222-otfnrarh 24 11 , , , cord-345222-otfnrarh 24 12 with with IN cord-345222-otfnrarh 24 13 or or CC cord-345222-otfnrarh 24 14 without without IN cord-345222-otfnrarh 24 15 vomiting vomit VBG cord-345222-otfnrarh 24 16 , , , cord-345222-otfnrarh 24 17 infectious infectious JJ cord-345222-otfnrarh 24 18 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 24 19 is be VBZ cord-345222-otfnrarh 24 20 by by IN cord-345222-otfnrarh 24 21 far far RB cord-345222-otfnrarh 24 22 the the DT cord-345222-otfnrarh 24 23 most most RBS cord-345222-otfnrarh 24 24 common common JJ cord-345222-otfnrarh 24 25 explanation explanation NN cord-345222-otfnrarh 24 26 . . . cord-345222-otfnrarh 25 1 4 4 LS cord-345222-otfnrarh 25 2 Viewed view VBN cord-345222-otfnrarh 25 3 from from IN cord-345222-otfnrarh 25 4 a a DT cord-345222-otfnrarh 25 5 global global JJ cord-345222-otfnrarh 25 6 perspective perspective NN cord-345222-otfnrarh 25 7 , , , cord-345222-otfnrarh 25 8 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 25 9 in in IN cord-345222-otfnrarh 25 10 children child NNS cord-345222-otfnrarh 25 11 is be VBZ cord-345222-otfnrarh 25 12 of of IN cord-345222-otfnrarh 25 13 enormous enormous JJ cord-345222-otfnrarh 25 14 public public JJ cord-345222-otfnrarh 25 15 health health NN cord-345222-otfnrarh 25 16 importance importance NN cord-345222-otfnrarh 25 17 . . . cord-345222-otfnrarh 26 1 Worldwide worldwide RB cord-345222-otfnrarh 26 2 , , , cord-345222-otfnrarh 26 3 about about RB cord-345222-otfnrarh 26 4 10.6 10.6 CD cord-345222-otfnrarh 26 5 million million CD cord-345222-otfnrarh 26 6 children child NNS cord-345222-otfnrarh 26 7 still still RB cord-345222-otfnrarh 26 8 die die VBP cord-345222-otfnrarh 26 9 every every DT cord-345222-otfnrarh 26 10 year year NN cord-345222-otfnrarh 26 11 before before IN cord-345222-otfnrarh 26 12 reaching reach VBG cord-345222-otfnrarh 26 13 their -PRON- PRP$ cord-345222-otfnrarh 26 14 fifth fifth JJ cord-345222-otfnrarh 26 15 birthday birthday NN cord-345222-otfnrarh 26 16 . . . cord-345222-otfnrarh 27 1 Gastroenteritis gastroenteritis NN cord-345222-otfnrarh 27 2 alone alone RB cord-345222-otfnrarh 27 3 is be VBZ cord-345222-otfnrarh 27 4 responsible responsible JJ cord-345222-otfnrarh 27 5 for for IN cord-345222-otfnrarh 27 6 almost almost RB cord-345222-otfnrarh 27 7 20 20 CD cord-345222-otfnrarh 27 8 % % NN cord-345222-otfnrarh 27 9 of of IN cord-345222-otfnrarh 27 10 the the DT cord-345222-otfnrarh 27 11 deaths death NNS cord-345222-otfnrarh 27 12 . . . cord-345222-otfnrarh 28 1 4 4 LS cord-345222-otfnrarh 29 1 In in IN cord-345222-otfnrarh 29 2 spite spite NN cord-345222-otfnrarh 29 3 of of IN cord-345222-otfnrarh 29 4 the the DT cord-345222-otfnrarh 29 5 intense intense JJ cord-345222-otfnrarh 29 6 promotion promotion NN cord-345222-otfnrarh 29 7 of of IN cord-345222-otfnrarh 29 8 oral oral JJ cord-345222-otfnrarh 29 9 rehydration rehydration NN cord-345222-otfnrarh 29 10 solution solution NN cord-345222-otfnrarh 29 11 ( ( -LRB- cord-345222-otfnrarh 29 12 ORS ORS NNP cord-345222-otfnrarh 29 13 ) ) -RRB- cord-345222-otfnrarh 29 14 at at IN cord-345222-otfnrarh 29 15 the the DT cord-345222-otfnrarh 29 16 community community NN cord-345222-otfnrarh 29 17 level level NN cord-345222-otfnrarh 29 18 and and CC cord-345222-otfnrarh 29 19 the the DT cord-345222-otfnrarh 29 20 training training NN cord-345222-otfnrarh 29 21 of of IN cord-345222-otfnrarh 29 22 health health NN cord-345222-otfnrarh 29 23 care care NN cord-345222-otfnrarh 29 24 workers worker NNS cord-345222-otfnrarh 29 25 , , , cord-345222-otfnrarh 29 26 diarrhea diarrhea NN cord-345222-otfnrarh 29 27 mortality mortality NN cord-345222-otfnrarh 29 28 remains remain VBZ cord-345222-otfnrarh 29 29 unacceptably unacceptably RB cord-345222-otfnrarh 29 30 high high JJ cord-345222-otfnrarh 29 31 : : : cord-345222-otfnrarh 29 32 more more JJR cord-345222-otfnrarh 29 33 than than IN cord-345222-otfnrarh 29 34 2 2 CD cord-345222-otfnrarh 29 35 million million CD cord-345222-otfnrarh 29 36 children child NNS cord-345222-otfnrarh 29 37 aged age VBN cord-345222-otfnrarh 29 38 less less JJR cord-345222-otfnrarh 29 39 than than IN cord-345222-otfnrarh 29 40 5 5 CD cord-345222-otfnrarh 29 41 years year NNS cord-345222-otfnrarh 29 42 die die VBP cord-345222-otfnrarh 29 43 each each DT cord-345222-otfnrarh 29 44 year year NN cord-345222-otfnrarh 29 45 from from IN cord-345222-otfnrarh 29 46 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 29 47 , , , cord-345222-otfnrarh 29 48 almost almost RB cord-345222-otfnrarh 29 49 all all DT cord-345222-otfnrarh 29 50 living live VBG cord-345222-otfnrarh 29 51 in in IN cord-345222-otfnrarh 29 52 resource resource NN cord-345222-otfnrarh 29 53 - - HYPH cord-345222-otfnrarh 29 54 constrained constrain VBN cord-345222-otfnrarh 29 55 nations nation NNS cord-345222-otfnrarh 29 56 , , , cord-345222-otfnrarh 29 57 where where WRB cord-345222-otfnrarh 29 58 acute acute JJ cord-345222-otfnrarh 29 59 diarrhea diarrhea NN cord-345222-otfnrarh 29 60 represents represent VBZ cord-345222-otfnrarh 29 61 a a DT cord-345222-otfnrarh 29 62 leading leading JJ cord-345222-otfnrarh 29 63 cause cause NN cord-345222-otfnrarh 29 64 of of IN cord-345222-otfnrarh 29 65 child child NN cord-345222-otfnrarh 29 66 mortality mortality NN cord-345222-otfnrarh 29 67 , , , cord-345222-otfnrarh 29 68 second second RB cord-345222-otfnrarh 29 69 only only RB cord-345222-otfnrarh 29 70 to to IN cord-345222-otfnrarh 29 71 pneumonia pneumonia NN cord-345222-otfnrarh 29 72 . . . cord-345222-otfnrarh 30 1 2 2 LS cord-345222-otfnrarh 30 2 AGE age NN cord-345222-otfnrarh 30 3 causes cause VBZ cord-345222-otfnrarh 30 4 1.5 1.5 CD cord-345222-otfnrarh 30 5 million million CD cord-345222-otfnrarh 30 6 visits visit NNS cord-345222-otfnrarh 30 7 to to IN cord-345222-otfnrarh 30 8 primary primary JJ cord-345222-otfnrarh 30 9 care care NN cord-345222-otfnrarh 30 10 providers provider NNS cord-345222-otfnrarh 30 11 each each DT cord-345222-otfnrarh 30 12 year year NN cord-345222-otfnrarh 30 13 and and CC cord-345222-otfnrarh 30 14 220,000 220,000 CD cord-345222-otfnrarh 30 15 hospital hospital NN cord-345222-otfnrarh 30 16 admissions admission NNS cord-345222-otfnrarh 30 17 for for IN cord-345222-otfnrarh 30 18 children child NNS cord-345222-otfnrarh 30 19 under under IN cord-345222-otfnrarh 30 20 the the DT cord-345222-otfnrarh 30 21 age age NN cord-345222-otfnrarh 30 22 of of IN cord-345222-otfnrarh 30 23 5 5 CD cord-345222-otfnrarh 30 24 years year NNS cord-345222-otfnrarh 30 25 ; ; : cord-345222-otfnrarh 30 26 that that DT cord-345222-otfnrarh 30 27 is be VBZ cord-345222-otfnrarh 30 28 10 10 CD cord-345222-otfnrarh 30 29 % % NN cord-345222-otfnrarh 30 30 of of IN cord-345222-otfnrarh 30 31 all all PDT cord-345222-otfnrarh 30 32 the the DT cord-345222-otfnrarh 30 33 hospital hospital NN cord-345222-otfnrarh 30 34 admissions admission NNS cord-345222-otfnrarh 30 35 of of IN cord-345222-otfnrarh 30 36 children child NNS cord-345222-otfnrarh 30 37 in in IN cord-345222-otfnrarh 30 38 the the DT cord-345222-otfnrarh 30 39 US US NNP cord-345222-otfnrarh 30 40 . . . cord-345222-otfnrarh 31 1 5 5 LS cord-345222-otfnrarh 32 1 In in IN cord-345222-otfnrarh 32 2 general general JJ cord-345222-otfnrarh 32 3 , , , cord-345222-otfnrarh 32 4 resource resource NN cord-345222-otfnrarh 32 5 - - HYPH cord-345222-otfnrarh 32 6 constrained constrain VBN cord-345222-otfnrarh 32 7 nations nation NNS cord-345222-otfnrarh 32 8 have have VBP cord-345222-otfnrarh 32 9 a a DT cord-345222-otfnrarh 32 10 higher high JJR cord-345222-otfnrarh 32 11 rate rate NN cord-345222-otfnrarh 32 12 of of IN cord-345222-otfnrarh 32 13 hospital hospital NN cord-345222-otfnrarh 32 14 admissions admission NNS cord-345222-otfnrarh 32 15 compared compare VBN cord-345222-otfnrarh 32 16 to to IN cord-345222-otfnrarh 32 17 rich rich JJ cord-345222-otfnrarh 32 18 nations nation NNS cord-345222-otfnrarh 32 19 . . . cord-345222-otfnrarh 33 1 6 6 CD cord-345222-otfnrarh 34 1 In in IN cord-345222-otfnrarh 34 2 the the DT cord-345222-otfnrarh 34 3 US US NNP cord-345222-otfnrarh 34 4 , , , cord-345222-otfnrarh 34 5 the the DT cord-345222-otfnrarh 34 6 admission admission NN cord-345222-otfnrarh 34 7 rate rate NN cord-345222-otfnrarh 34 8 is be VBZ cord-345222-otfnrarh 34 9 nine nine CD cord-345222-otfnrarh 34 10 per per IN cord-345222-otfnrarh 34 11 1000 1000 CD cord-345222-otfnrarh 34 12 , , , cord-345222-otfnrarh 34 13 per per IN cord-345222-otfnrarh 34 14 year year NN cord-345222-otfnrarh 34 15 , , , cord-345222-otfnrarh 34 16 for for IN cord-345222-otfnrarh 34 17 children child NNS cord-345222-otfnrarh 34 18 younger young JJR cord-345222-otfnrarh 34 19 than than IN cord-345222-otfnrarh 34 20 5 5 CD cord-345222-otfnrarh 34 21 years year NNS cord-345222-otfnrarh 34 22 old old JJ cord-345222-otfnrarh 34 23 . . . cord-345222-otfnrarh 35 1 5 5 LS cord-345222-otfnrarh 36 1 In in IN cord-345222-otfnrarh 36 2 England England NNP cord-345222-otfnrarh 36 3 each each DT cord-345222-otfnrarh 36 4 year year NN cord-345222-otfnrarh 36 5 , , , cord-345222-otfnrarh 36 6 9.4 9.4 CD cord-345222-otfnrarh 36 7 million million CD cord-345222-otfnrarh 36 8 cases case NNS cord-345222-otfnrarh 36 9 of of IN cord-345222-otfnrarh 36 10 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 36 11 occur occur VBP cord-345222-otfnrarh 36 12 in in IN cord-345222-otfnrarh 36 13 the the DT cord-345222-otfnrarh 36 14 community community NN cord-345222-otfnrarh 36 15 and and CC cord-345222-otfnrarh 36 16 1.5 1.5 CD cord-345222-otfnrarh 36 17 million million CD cord-345222-otfnrarh 36 18 present present JJ cord-345222-otfnrarh 36 19 to to IN cord-345222-otfnrarh 36 20 their -PRON- PRP$ cord-345222-otfnrarh 36 21 primary primary JJ cord-345222-otfnrarh 36 22 care care NN cord-345222-otfnrarh 36 23 doctor doctor NN cord-345222-otfnrarh 36 24 . . . cord-345222-otfnrarh 37 1 4 4 LS cord-345222-otfnrarh 38 1 In in IN cord-345222-otfnrarh 38 2 Europe Europe NNP cord-345222-otfnrarh 38 3 , , , cord-345222-otfnrarh 38 4 rotavirus rotavirus JJ cord-345222-otfnrarh 38 5 infection infection NN cord-345222-otfnrarh 38 6 accounts account VBZ cord-345222-otfnrarh 38 7 for for IN cord-345222-otfnrarh 38 8 more more JJR cord-345222-otfnrarh 38 9 than than IN cord-345222-otfnrarh 38 10 50 50 CD cord-345222-otfnrarh 38 11 % % NN cord-345222-otfnrarh 38 12 of of IN cord-345222-otfnrarh 38 13 hospitalizations hospitalization NNS cord-345222-otfnrarh 38 14 for for IN cord-345222-otfnrarh 38 15 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 38 16 and and CC cord-345222-otfnrarh 38 17 about about RB cord-345222-otfnrarh 38 18 one one CD cord-345222-otfnrarh 38 19 - - HYPH cord-345222-otfnrarh 38 20 third third NN cord-345222-otfnrarh 38 21 of of IN cord-345222-otfnrarh 38 22 emergency emergency NN cord-345222-otfnrarh 38 23 department department NN cord-345222-otfnrarh 38 24 visits visit NNS cord-345222-otfnrarh 38 25 . . . cord-345222-otfnrarh 39 1 2 2 LS cord-345222-otfnrarh 39 2 , , , cord-345222-otfnrarh 39 3 6 6 CD cord-345222-otfnrarh 39 4 , , , cord-345222-otfnrarh 39 5 7 7 CD cord-345222-otfnrarh 39 6 Not not RB cord-345222-otfnrarh 39 7 surprisingly surprisingly RB cord-345222-otfnrarh 39 8 , , , cord-345222-otfnrarh 39 9 the the DT cord-345222-otfnrarh 39 10 economic economic JJ cord-345222-otfnrarh 39 11 burden burden NN cord-345222-otfnrarh 39 12 of of IN cord-345222-otfnrarh 39 13 acute acute JJ cord-345222-otfnrarh 39 14 diarrhea diarrhea NN cord-345222-otfnrarh 39 15 is be VBZ cord-345222-otfnrarh 39 16 substantial substantial JJ cord-345222-otfnrarh 39 17 , , , cord-345222-otfnrarh 39 18 not not RB cord-345222-otfnrarh 39 19 only only RB cord-345222-otfnrarh 39 20 in in IN cord-345222-otfnrarh 39 21 management management NN cord-345222-otfnrarh 39 22 costs cost NNS cord-345222-otfnrarh 39 23 but but CC cord-345222-otfnrarh 39 24 also also RB cord-345222-otfnrarh 39 25 in in IN cord-345222-otfnrarh 39 26 indirect indirect JJ cord-345222-otfnrarh 39 27 costs cost NNS cord-345222-otfnrarh 39 28 , , , cord-345222-otfnrarh 39 29 such such JJ cord-345222-otfnrarh 39 30 as as IN cord-345222-otfnrarh 39 31 absence absence NN cord-345222-otfnrarh 39 32 from from IN cord-345222-otfnrarh 39 33 work work NN cord-345222-otfnrarh 39 34 by by IN cord-345222-otfnrarh 39 35 parents parent NNS cord-345222-otfnrarh 39 36 or or CC cord-345222-otfnrarh 39 37 caregivers caregiver NNS cord-345222-otfnrarh 39 38 of of IN cord-345222-otfnrarh 39 39 sick sick JJ cord-345222-otfnrarh 39 40 children child NNS cord-345222-otfnrarh 39 41 . . . cord-345222-otfnrarh 40 1 2 2 LS cord-345222-otfnrarh 41 1 The the DT cord-345222-otfnrarh 41 2 severity severity NN cord-345222-otfnrarh 41 3 of of IN cord-345222-otfnrarh 41 4 acute acute JJ cord-345222-otfnrarh 41 5 diarrhea diarrhea NN cord-345222-otfnrarh 41 6 is be VBZ cord-345222-otfnrarh 41 7 related relate VBN cord-345222-otfnrarh 41 8 to to IN cord-345222-otfnrarh 41 9 etiology etiology NN cord-345222-otfnrarh 41 10 , , , cord-345222-otfnrarh 41 11 with with IN cord-345222-otfnrarh 41 12 rotavirus rotavirus JJ cord-345222-otfnrarh 41 13 infection infection NN cord-345222-otfnrarh 41 14 disproportionately disproportionately RB cord-345222-otfnrarh 41 15 implicated implicate VBN cord-345222-otfnrarh 41 16 in in IN cord-345222-otfnrarh 41 17 severe severe JJ cord-345222-otfnrarh 41 18 cases case NNS cord-345222-otfnrarh 41 19 that that WDT cord-345222-otfnrarh 41 20 frequently frequently RB cord-345222-otfnrarh 41 21 require require VBP cord-345222-otfnrarh 41 22 hospitalization hospitalization NN cord-345222-otfnrarh 41 23 . . . cord-345222-otfnrarh 42 1 2 2 LS cord-345222-otfnrarh 42 2 , , , cord-345222-otfnrarh 42 3 8 8 CD cord-345222-otfnrarh 42 4 Worldwide Worldwide NNP cord-345222-otfnrarh 42 5 , , , cord-345222-otfnrarh 42 6 up up IN cord-345222-otfnrarh 42 7 to to TO cord-345222-otfnrarh 42 8 40 40 CD cord-345222-otfnrarh 42 9 % % NN cord-345222-otfnrarh 42 10 of of IN cord-345222-otfnrarh 42 11 children child NNS cord-345222-otfnrarh 42 12 aged age VBN cord-345222-otfnrarh 42 13 less less JJR cord-345222-otfnrarh 42 14 than than IN cord-345222-otfnrarh 42 15 5 5 CD cord-345222-otfnrarh 42 16 years year NNS cord-345222-otfnrarh 42 17 with with IN cord-345222-otfnrarh 42 18 diarrhea diarrhea NN cord-345222-otfnrarh 42 19 are be VBP cord-345222-otfnrarh 42 20 hospitalized hospitalize VBN cord-345222-otfnrarh 42 21 with with IN cord-345222-otfnrarh 42 22 rotavirus rotavirus NN cord-345222-otfnrarh 42 23 : : : cord-345222-otfnrarh 42 24 while while IN cord-345222-otfnrarh 42 25 most most JJS cord-345222-otfnrarh 42 26 of of IN cord-345222-otfnrarh 42 27 the the DT cord-345222-otfnrarh 42 28 episodes episode NNS cord-345222-otfnrarh 42 29 are be VBP cord-345222-otfnrarh 42 30 mild mild JJ cord-345222-otfnrarh 42 31 , , , cord-345222-otfnrarh 42 32 about about RB cord-345222-otfnrarh 42 33 10 10 CD cord-345222-otfnrarh 42 34 % % NN cord-345222-otfnrarh 42 35 of of IN cord-345222-otfnrarh 42 36 cases case NNS cord-345222-otfnrarh 42 37 lead lead VBP cord-345222-otfnrarh 42 38 to to IN cord-345222-otfnrarh 42 39 dehydration dehydration NN cord-345222-otfnrarh 42 40 requiring require VBG cord-345222-otfnrarh 42 41 a a DT cord-345222-otfnrarh 42 42 doctor doctor NN cord-345222-otfnrarh 42 43 visit visit NN cord-345222-otfnrarh 42 44 , , , cord-345222-otfnrarh 42 45 and and CC cord-345222-otfnrarh 42 46 in in IN cord-345222-otfnrarh 42 47 resource resource NN cord-345222-otfnrarh 42 48 - - HYPH cord-345222-otfnrarh 42 49 constrained constrain VBN cord-345222-otfnrarh 42 50 nations nation NNS cord-345222-otfnrarh 42 51 , , , cord-345222-otfnrarh 42 52 one one CD cord-345222-otfnrarh 42 53 in in IN cord-345222-otfnrarh 42 54 250 250 CD cord-345222-otfnrarh 42 55 children child NNS cord-345222-otfnrarh 42 56 will will MD cord-345222-otfnrarh 42 57 die die VB cord-345222-otfnrarh 42 58 from from IN cord-345222-otfnrarh 42 59 this this DT cord-345222-otfnrarh 42 60 dehydration dehydration NN cord-345222-otfnrarh 42 61 . . . cord-345222-otfnrarh 43 1 [ [ -LRB- cord-345222-otfnrarh 43 2 7 7 CD cord-345222-otfnrarh 43 3 ] ] -RRB- cord-345222-otfnrarh 43 4 [ [ -LRB- cord-345222-otfnrarh 43 5 8 8 CD cord-345222-otfnrarh 43 6 ] ] -RRB- cord-345222-otfnrarh 43 7 [ [ -LRB- cord-345222-otfnrarh 43 8 9 9 CD cord-345222-otfnrarh 43 9 ] ] -RRB- cord-345222-otfnrarh 43 10 [ [ -LRB- cord-345222-otfnrarh 43 11 10 10 CD cord-345222-otfnrarh 43 12 ] ] -RRB- cord-345222-otfnrarh 43 13 [ [ -LRB- cord-345222-otfnrarh 43 14 11 11 CD cord-345222-otfnrarh 43 15 ] ] -RRB- cord-345222-otfnrarh 44 1 In in IN cord-345222-otfnrarh 44 2 Europe Europe NNP cord-345222-otfnrarh 44 3 , , , cord-345222-otfnrarh 44 4 rotavirus rotavirus JJ cord-345222-otfnrarh 44 5 infection infection NN cord-345222-otfnrarh 44 6 accounts account VBZ cord-345222-otfnrarh 44 7 for for IN cord-345222-otfnrarh 44 8 more more JJR cord-345222-otfnrarh 44 9 than than IN cord-345222-otfnrarh 44 10 50 50 CD cord-345222-otfnrarh 44 11 % % NN cord-345222-otfnrarh 44 12 of of IN cord-345222-otfnrarh 44 13 hospitalizations hospitalization NNS cord-345222-otfnrarh 44 14 for for IN cord-345222-otfnrarh 44 15 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 44 16 and and CC cord-345222-otfnrarh 44 17 about about RB cord-345222-otfnrarh 44 18 one one CD cord-345222-otfnrarh 44 19 - - HYPH cord-345222-otfnrarh 44 20 third third NN cord-345222-otfnrarh 44 21 of of IN cord-345222-otfnrarh 44 22 emergency emergency NN cord-345222-otfnrarh 44 23 department department NN cord-345222-otfnrarh 44 24 visits visit NNS cord-345222-otfnrarh 44 25 . . . cord-345222-otfnrarh 45 1 2 2 LS cord-345222-otfnrarh 45 2 , , , cord-345222-otfnrarh 45 3 7 7 CD cord-345222-otfnrarh 46 1 Otherwise otherwise RB cord-345222-otfnrarh 46 2 , , , cord-345222-otfnrarh 46 3 some some DT cord-345222-otfnrarh 46 4 agents agent NNS cord-345222-otfnrarh 46 5 have have VBP cord-345222-otfnrarh 46 6 been be VBN cord-345222-otfnrarh 46 7 found find VBN cord-345222-otfnrarh 46 8 predominantly predominantly RB cord-345222-otfnrarh 46 9 in in IN cord-345222-otfnrarh 46 10 resource resource NN cord-345222-otfnrarh 46 11 - - HYPH cord-345222-otfnrarh 46 12 constrained constrain VBN cord-345222-otfnrarh 46 13 nations nation NNS cord-345222-otfnrarh 46 14 , , , cord-345222-otfnrarh 46 15 including include VBG cord-345222-otfnrarh 46 16 Shigella Shigella NNP cord-345222-otfnrarh 46 17 spp spp NNS cord-345222-otfnrarh 46 18 , , , cord-345222-otfnrarh 46 19 Vibrio Vibrio NNP cord-345222-otfnrarh 46 20 cholerae cholerae NN cord-345222-otfnrarh 46 21 , , , cord-345222-otfnrarh 46 22 and and CC cord-345222-otfnrarh 46 23 the the DT cord-345222-otfnrarh 46 24 protozoan protozoan NN cord-345222-otfnrarh 46 25 infections infection NNS cord-345222-otfnrarh 46 26 . . . cord-345222-otfnrarh 47 1 Mode mode NN cord-345222-otfnrarh 47 2 of of IN cord-345222-otfnrarh 47 3 transmission transmission NN cord-345222-otfnrarh 47 4 is be VBZ cord-345222-otfnrarh 47 5 mainly mainly RB cord-345222-otfnrarh 47 6 horizontal horizontal JJ cord-345222-otfnrarh 47 7 , , , cord-345222-otfnrarh 47 8 through through IN cord-345222-otfnrarh 47 9 physical physical JJ cord-345222-otfnrarh 47 10 contact contact NN cord-345222-otfnrarh 47 11 with with IN cord-345222-otfnrarh 47 12 an an DT cord-345222-otfnrarh 47 13 infected infected JJ cord-345222-otfnrarh 47 14 person person NN cord-345222-otfnrarh 47 15 or or CC cord-345222-otfnrarh 47 16 with with IN cord-345222-otfnrarh 47 17 their -PRON- PRP$ cord-345222-otfnrarh 47 18 excretions excretion NNS cord-345222-otfnrarh 47 19 . . . cord-345222-otfnrarh 48 1 The the DT cord-345222-otfnrarh 48 2 pathogens pathogen NNS cord-345222-otfnrarh 48 3 , , , cord-345222-otfnrarh 48 4 most most RBS cord-345222-otfnrarh 48 5 frequently frequently RB cord-345222-otfnrarh 48 6 transmitted transmit VBN cord-345222-otfnrarh 48 7 during during IN cord-345222-otfnrarh 48 8 the the DT cord-345222-otfnrarh 48 9 passage passage NN cord-345222-otfnrarh 48 10 through through IN cord-345222-otfnrarh 48 11 the the DT cord-345222-otfnrarh 48 12 birth birth NN cord-345222-otfnrarh 48 13 canal canal NN cord-345222-otfnrarh 48 14 , , , cord-345222-otfnrarh 48 15 are be VBP cord-345222-otfnrarh 48 16 enteropathogenic enteropathogenic JJ cord-345222-otfnrarh 48 17 Escherichia Escherichia NNP cord-345222-otfnrarh 48 18 coli coli NNS cord-345222-otfnrarh 48 19 , , , cord-345222-otfnrarh 48 20 Salmonella salmonella NN cord-345222-otfnrarh 48 21 , , , cord-345222-otfnrarh 48 22 and and CC cord-345222-otfnrarh 48 23 enterovirus enterovirus NN cord-345222-otfnrarh 48 24 . . . cord-345222-otfnrarh 49 1 Although although IN cord-345222-otfnrarh 49 2 rare rare JJ cord-345222-otfnrarh 49 3 , , , cord-345222-otfnrarh 49 4 the the DT cord-345222-otfnrarh 49 5 passage passage NN cord-345222-otfnrarh 49 6 of of IN cord-345222-otfnrarh 49 7 the the DT cord-345222-otfnrarh 49 8 germ germ NN cord-345222-otfnrarh 49 9 can can MD cord-345222-otfnrarh 49 10 also also RB cord-345222-otfnrarh 49 11 occur occur VB cord-345222-otfnrarh 49 12 transplacentally transplacentally RB cord-345222-otfnrarh 49 13 during during IN cord-345222-otfnrarh 49 14 bacteremia bacteremia NN cord-345222-otfnrarh 49 15 . . . cord-345222-otfnrarh 50 1 Several several JJ cord-345222-otfnrarh 50 2 maternal maternal JJ cord-345222-otfnrarh 50 3 infections infection NNS cord-345222-otfnrarh 50 4 are be VBP cord-345222-otfnrarh 50 5 asymptomatic asymptomatic JJ cord-345222-otfnrarh 50 6 . . . cord-345222-otfnrarh 51 1 Horizontal horizontal JJ cord-345222-otfnrarh 51 2 transmission transmission NN cord-345222-otfnrarh 51 3 can can MD cord-345222-otfnrarh 51 4 occur occur VB cord-345222-otfnrarh 51 5 through through IN cord-345222-otfnrarh 51 6 direct direct JJ cord-345222-otfnrarh 51 7 contact contact NN cord-345222-otfnrarh 51 8 with with IN cord-345222-otfnrarh 51 9 siblings sibling NNS cord-345222-otfnrarh 51 10 , , , cord-345222-otfnrarh 51 11 parents parent NNS cord-345222-otfnrarh 51 12 , , , cord-345222-otfnrarh 51 13 or or CC cord-345222-otfnrarh 51 14 health health NN cord-345222-otfnrarh 51 15 care care NN cord-345222-otfnrarh 51 16 workers worker NNS cord-345222-otfnrarh 51 17 . . . cord-345222-otfnrarh 52 1 Some some DT cord-345222-otfnrarh 52 2 cases case NNS cord-345222-otfnrarh 52 3 of of IN cord-345222-otfnrarh 52 4 transmission transmission NN cord-345222-otfnrarh 52 5 through through IN cord-345222-otfnrarh 52 6 the the DT cord-345222-otfnrarh 52 7 ingestion ingestion NN cord-345222-otfnrarh 52 8 of of IN cord-345222-otfnrarh 52 9 contaminated contaminated JJ cord-345222-otfnrarh 52 10 water water NN cord-345222-otfnrarh 52 11 or or CC cord-345222-otfnrarh 52 12 infant infant NN cord-345222-otfnrarh 52 13 formula formula NN cord-345222-otfnrarh 52 14 are be VBP cord-345222-otfnrarh 52 15 also also RB cord-345222-otfnrarh 52 16 reported report VBN cord-345222-otfnrarh 52 17 . . . cord-345222-otfnrarh 53 1 Some some DT cord-345222-otfnrarh 53 2 viral viral JJ cord-345222-otfnrarh 53 3 infectious infectious JJ cord-345222-otfnrarh 53 4 agents agent NNS cord-345222-otfnrarh 53 5 , , , cord-345222-otfnrarh 53 6 such such JJ cord-345222-otfnrarh 53 7 as as IN cord-345222-otfnrarh 53 8 adenovirus adenovirus NN cord-345222-otfnrarh 53 9 and and CC cord-345222-otfnrarh 53 10 rotavirus rotavirus NN cord-345222-otfnrarh 53 11 , , , cord-345222-otfnrarh 53 12 can can MD cord-345222-otfnrarh 53 13 be be VB cord-345222-otfnrarh 53 14 transmitted transmit VBN cord-345222-otfnrarh 53 15 by by IN cord-345222-otfnrarh 53 16 air air NN cord-345222-otfnrarh 53 17 . . . cord-345222-otfnrarh 54 1 12 12 CD cord-345222-otfnrarh 55 1 The the DT cord-345222-otfnrarh 55 2 relatively relatively RB cord-345222-otfnrarh 55 3 low low JJ cord-345222-otfnrarh 55 4 incidence incidence NN cord-345222-otfnrarh 55 5 of of IN cord-345222-otfnrarh 55 6 the the DT cord-345222-otfnrarh 55 7 disease disease NN cord-345222-otfnrarh 55 8 in in IN cord-345222-otfnrarh 55 9 newborns newborn NNS cord-345222-otfnrarh 55 10 is be VBZ cord-345222-otfnrarh 55 11 the the DT cord-345222-otfnrarh 55 12 result result NN cord-345222-otfnrarh 55 13 of of IN cord-345222-otfnrarh 55 14 several several JJ cord-345222-otfnrarh 55 15 factors factor NNS cord-345222-otfnrarh 55 16 : : : cord-345222-otfnrarh 55 17 breastfeeding breastfeeding NN cord-345222-otfnrarh 55 18 and and CC cord-345222-otfnrarh 55 19 the the DT cord-345222-otfnrarh 55 20 universal universal JJ cord-345222-otfnrarh 55 21 practice practice NN cord-345222-otfnrarh 55 22 of of IN cord-345222-otfnrarh 55 23 giving give VBG cord-345222-otfnrarh 55 24 birth birth NN cord-345222-otfnrarh 55 25 at at IN cord-345222-otfnrarh 55 26 home home NN cord-345222-otfnrarh 55 27 in in IN cord-345222-otfnrarh 55 28 rural rural JJ cord-345222-otfnrarh 55 29 villages village NNS cord-345222-otfnrarh 55 30 , , , cord-345222-otfnrarh 55 31 and and CC cord-345222-otfnrarh 55 32 improvements improvement NNS cord-345222-otfnrarh 55 33 in in IN cord-345222-otfnrarh 55 34 social social JJ cord-345222-otfnrarh 55 35 and and CC cord-345222-otfnrarh 55 36 educational educational JJ cord-345222-otfnrarh 55 37 standards standard NNS cord-345222-otfnrarh 55 38 and and CC cord-345222-otfnrarh 55 39 medical medical JJ cord-345222-otfnrarh 55 40 care care NN cord-345222-otfnrarh 55 41 in in IN cord-345222-otfnrarh 55 42 advanced advanced JJ cord-345222-otfnrarh 55 43 countries country NNS cord-345222-otfnrarh 55 44 . . . cord-345222-otfnrarh 56 1 13 13 CD cord-345222-otfnrarh 57 1 , , , cord-345222-otfnrarh 57 2 14 14 CD cord-345222-otfnrarh 58 1 Otherwise otherwise RB cord-345222-otfnrarh 58 2 , , , cord-345222-otfnrarh 58 3 newborns newborn NNS cord-345222-otfnrarh 58 4 are be VBP cord-345222-otfnrarh 58 5 particularly particularly RB cord-345222-otfnrarh 58 6 susceptible susceptible JJ cord-345222-otfnrarh 58 7 to to IN cord-345222-otfnrarh 58 8 enteric enteric JJ cord-345222-otfnrarh 58 9 infections infection NNS cord-345222-otfnrarh 58 10 in in IN cord-345222-otfnrarh 58 11 early early JJ cord-345222-otfnrarh 58 12 life life NN cord-345222-otfnrarh 58 13 , , , cord-345222-otfnrarh 58 14 due due IN cord-345222-otfnrarh 58 15 to to IN cord-345222-otfnrarh 58 16 reduced reduce VBN cord-345222-otfnrarh 58 17 local local JJ cord-345222-otfnrarh 58 18 and and CC cord-345222-otfnrarh 58 19 systemic systemic JJ cord-345222-otfnrarh 58 20 immune immune JJ cord-345222-otfnrarh 58 21 response response NN cord-345222-otfnrarh 58 22 , , , cord-345222-otfnrarh 58 23 absence absence NN cord-345222-otfnrarh 58 24 of of IN cord-345222-otfnrarh 58 25 an an DT cord-345222-otfnrarh 58 26 adequate adequate JJ cord-345222-otfnrarh 58 27 intestinal intestinal JJ cord-345222-otfnrarh 58 28 flora flora NNS cord-345222-otfnrarh 58 29 , , , cord-345222-otfnrarh 58 30 and and CC cord-345222-otfnrarh 58 31 reduced reduce VBN cord-345222-otfnrarh 58 32 gastric gastric JJ cord-345222-otfnrarh 58 33 acidity acidity NN cord-345222-otfnrarh 58 34 . . . cord-345222-otfnrarh 59 1 In in IN cord-345222-otfnrarh 59 2 the the DT cord-345222-otfnrarh 59 3 newborn newborn NN cord-345222-otfnrarh 59 4 , , , cord-345222-otfnrarh 59 5 the the DT cord-345222-otfnrarh 59 6 protective protective JJ cord-345222-otfnrarh 59 7 role role NN cord-345222-otfnrarh 59 8 of of IN cord-345222-otfnrarh 59 9 gastric gastric JJ cord-345222-otfnrarh 59 10 motility motility NN cord-345222-otfnrarh 59 11 and and CC cord-345222-otfnrarh 59 12 of of IN cord-345222-otfnrarh 59 13 the the DT cord-345222-otfnrarh 59 14 intestinal intestinal JJ cord-345222-otfnrarh 59 15 mucus mucus NN cord-345222-otfnrarh 59 16 is be VBZ cord-345222-otfnrarh 59 17 still still RB cord-345222-otfnrarh 59 18 uncertain uncertain JJ cord-345222-otfnrarh 59 19 . . . cord-345222-otfnrarh 60 1 Other other JJ cord-345222-otfnrarh 60 2 external external JJ cord-345222-otfnrarh 60 3 factors factor NNS cord-345222-otfnrarh 60 4 contribute contribute VBP cord-345222-otfnrarh 60 5 to to IN cord-345222-otfnrarh 60 6 the the DT cord-345222-otfnrarh 60 7 balance balance NN cord-345222-otfnrarh 60 8 of of IN cord-345222-otfnrarh 60 9 the the DT cord-345222-otfnrarh 60 10 intestinal intestinal JJ cord-345222-otfnrarh 60 11 ecosystem ecosystem NN cord-345222-otfnrarh 60 12 : : : cord-345222-otfnrarh 60 13 nutrition nutrition NN cord-345222-otfnrarh 60 14 , , , cord-345222-otfnrarh 60 15 type type NN cord-345222-otfnrarh 60 16 of of IN cord-345222-otfnrarh 60 17 delivery delivery NN cord-345222-otfnrarh 60 18 , , , cord-345222-otfnrarh 60 19 hygiene hygiene NN cord-345222-otfnrarh 60 20 habits habit NNS cord-345222-otfnrarh 60 21 , , , cord-345222-otfnrarh 60 22 use use NN cord-345222-otfnrarh 60 23 of of IN cord-345222-otfnrarh 60 24 antibiotics antibiotic NNS cord-345222-otfnrarh 60 25 in in IN cord-345222-otfnrarh 60 26 the the DT cord-345222-otfnrarh 60 27 mother mother NN cord-345222-otfnrarh 60 28 and and CC cord-345222-otfnrarh 60 29 infant infant NN cord-345222-otfnrarh 60 30 and and CC cord-345222-otfnrarh 60 31 the the DT cord-345222-otfnrarh 60 32 supplementation supplementation NN cord-345222-otfnrarh 60 33 with with IN cord-345222-otfnrarh 60 34 probiotics probiotic NNS cord-345222-otfnrarh 60 35 and/or and/or CC cord-345222-otfnrarh 60 36 prebiotic prebiotic JJ cord-345222-otfnrarh 60 37 oligosaccharides oligosaccharide NNS cord-345222-otfnrarh 60 38 in in IN cord-345222-otfnrarh 60 39 the the DT cord-345222-otfnrarh 60 40 newborn newborn NN cord-345222-otfnrarh 60 41 . . . cord-345222-otfnrarh 61 1 [ [ -LRB- cord-345222-otfnrarh 61 2 15 15 CD cord-345222-otfnrarh 61 3 ] ] -RRB- cord-345222-otfnrarh 61 4 [ [ -LRB- cord-345222-otfnrarh 61 5 16 16 CD cord-345222-otfnrarh 61 6 ] ] -RRB- cord-345222-otfnrarh 62 1 [ [ -LRB- cord-345222-otfnrarh 62 2 17 17 CD cord-345222-otfnrarh 62 3 ] ] -RRB- cord-345222-otfnrarh 63 1 The the DT cord-345222-otfnrarh 63 2 mortality mortality NN cord-345222-otfnrarh 63 3 risk risk NN cord-345222-otfnrarh 63 4 for for IN cord-345222-otfnrarh 63 5 very very RB cord-345222-otfnrarh 63 6 low low JJ cord-345222-otfnrarh 63 7 - - HYPH cord-345222-otfnrarh 63 8 birth birth NN cord-345222-otfnrarh 63 9 - - HYPH cord-345222-otfnrarh 63 10 weight weight NN cord-345222-otfnrarh 63 11 infants infant NNS cord-345222-otfnrarh 63 12 ( ( -LRB- cord-345222-otfnrarh 63 13 less less JJR cord-345222-otfnrarh 63 14 than than IN cord-345222-otfnrarh 63 15 1500 1500 CD cord-345222-otfnrarh 63 16 g g NN cord-345222-otfnrarh 63 17 ) ) -RRB- cord-345222-otfnrarh 63 18 due due JJ cord-345222-otfnrarh 63 19 to to IN cord-345222-otfnrarh 63 20 acute acute JJ cord-345222-otfnrarh 63 21 diarrhea diarrhea NN cord-345222-otfnrarh 63 22 is be VBZ cord-345222-otfnrarh 63 23 100 100 CD cord-345222-otfnrarh 63 24 times time NNS cord-345222-otfnrarh 63 25 higher high JJR cord-345222-otfnrarh 63 26 than than IN cord-345222-otfnrarh 63 27 for for IN cord-345222-otfnrarh 63 28 infants infant NNS cord-345222-otfnrarh 63 29 of of IN cord-345222-otfnrarh 63 30 low low JJ cord-345222-otfnrarh 63 31 or or CC cord-345222-otfnrarh 63 32 appropriate appropriate JJ cord-345222-otfnrarh 63 33 birth birth NN cord-345222-otfnrarh 63 34 weight weight NN cord-345222-otfnrarh 63 35 ( ( -LRB- cord-345222-otfnrarh 63 36 more more JJR cord-345222-otfnrarh 63 37 than than IN cord-345222-otfnrarh 63 38 1500 1500 CD cord-345222-otfnrarh 63 39 g g NN cord-345222-otfnrarh 63 40 ) ) -RRB- cord-345222-otfnrarh 63 41 . . . cord-345222-otfnrarh 64 1 Acute acute JJ cord-345222-otfnrarh 64 2 diarrhea diarrhea NN cord-345222-otfnrarh 64 3 has have VBZ cord-345222-otfnrarh 64 4 several several JJ cord-345222-otfnrarh 64 5 risks risk NNS cord-345222-otfnrarh 64 6 and and CC cord-345222-otfnrarh 64 7 complications complication NNS cord-345222-otfnrarh 64 8 ; ; : cord-345222-otfnrarh 64 9 it -PRON- PRP cord-345222-otfnrarh 64 10 may may MD cord-345222-otfnrarh 64 11 lead lead VB cord-345222-otfnrarh 64 12 to to IN cord-345222-otfnrarh 64 13 lifethreatening lifethreatening JJ cord-345222-otfnrarh 64 14 dehydration dehydration NN cord-345222-otfnrarh 64 15 and and CC cord-345222-otfnrarh 64 16 electrolyte electrolyte JJ cord-345222-otfnrarh 64 17 disturbances disturbance NNS cord-345222-otfnrarh 64 18 . . . cord-345222-otfnrarh 65 1 When when WRB cord-345222-otfnrarh 65 2 diarrhea diarrhea NN cord-345222-otfnrarh 65 3 is be VBZ cord-345222-otfnrarh 65 4 not not RB cord-345222-otfnrarh 65 5 halted halt VBN cord-345222-otfnrarh 65 6 , , , cord-345222-otfnrarh 65 7 there there EX cord-345222-otfnrarh 65 8 is be VBZ cord-345222-otfnrarh 65 9 a a DT cord-345222-otfnrarh 65 10 risk risk NN cord-345222-otfnrarh 65 11 of of IN cord-345222-otfnrarh 65 12 disturbed disturbed JJ cord-345222-otfnrarh 65 13 digestion digestion NN cord-345222-otfnrarh 65 14 and and CC cord-345222-otfnrarh 65 15 absorption absorption NN cord-345222-otfnrarh 65 16 of of IN cord-345222-otfnrarh 65 17 nutrients nutrient NNS cord-345222-otfnrarh 65 18 with with IN cord-345222-otfnrarh 65 19 nutritional nutritional JJ cord-345222-otfnrarh 65 20 deterioration deterioration NN cord-345222-otfnrarh 65 21 . . . cord-345222-otfnrarh 66 1 13 13 CD cord-345222-otfnrarh 66 2 Prevention Prevention NNP cord-345222-otfnrarh 66 3 is be VBZ cord-345222-otfnrarh 66 4 essential essential JJ cord-345222-otfnrarh 66 5 , , , cord-345222-otfnrarh 66 6 and and CC cord-345222-otfnrarh 66 7 all all DT cord-345222-otfnrarh 66 8 health health NN cord-345222-otfnrarh 66 9 professionals professional NNS cord-345222-otfnrarh 66 10 should should MD cord-345222-otfnrarh 66 11 ensure ensure VB cord-345222-otfnrarh 66 12 caregiver caregiver NN cord-345222-otfnrarh 66 13 education education NN cord-345222-otfnrarh 66 14 in in IN cord-345222-otfnrarh 66 15 the the DT cord-345222-otfnrarh 66 16 following follow VBG cord-345222-otfnrarh 66 17 main main JJ cord-345222-otfnrarh 66 18 principles principle NNS cord-345222-otfnrarh 66 19 of of IN cord-345222-otfnrarh 66 20 prevention prevention NN cord-345222-otfnrarh 66 21 : : : cord-345222-otfnrarh 66 22 13 13 CD cord-345222-otfnrarh 67 1 • • NNP cord-345222-otfnrarh 68 1 Full full JJ cord-345222-otfnrarh 68 2 and and CC cord-345222-otfnrarh 68 3 exclusive exclusive JJ cord-345222-otfnrarh 68 4 breastfeeding breastfeeding NN cord-345222-otfnrarh 68 5 that that WDT cord-345222-otfnrarh 68 6 protects protect VBZ cord-345222-otfnrarh 68 7 against against IN cord-345222-otfnrarh 68 8 intestinal intestinal JJ cord-345222-otfnrarh 68 9 infections infection NNS cord-345222-otfnrarh 68 10 and and CC cord-345222-otfnrarh 68 11 prevents prevent VBZ cord-345222-otfnrarh 68 12 exposure exposure NN cord-345222-otfnrarh 68 13 to to IN cord-345222-otfnrarh 68 14 environmental environmental JJ cord-345222-otfnrarh 68 15 contamination contamination NN cord-345222-otfnrarh 68 16 . . . cord-345222-otfnrarh 69 1 18 18 CD cord-345222-otfnrarh 69 2 , , , cord-345222-otfnrarh 69 3 19 19 CD cord-345222-otfnrarh 69 4 Thriving thrive VBG cord-345222-otfnrarh 69 5 breastfed breastfed JJ cord-345222-otfnrarh 69 6 babies baby NNS cord-345222-otfnrarh 69 7 under under IN cord-345222-otfnrarh 69 8 6 6 CD cord-345222-otfnrarh 69 9 months month NNS cord-345222-otfnrarh 69 10 of of IN cord-345222-otfnrarh 69 11 age age NN cord-345222-otfnrarh 69 12 do do VBP cord-345222-otfnrarh 69 13 not not RB cord-345222-otfnrarh 69 14 require require VB cord-345222-otfnrarh 69 15 water water NN cord-345222-otfnrarh 69 16 supplements supplement NNS cord-345222-otfnrarh 69 17 , , , cord-345222-otfnrarh 69 18 even even RB cord-345222-otfnrarh 69 19 in in IN cord-345222-otfnrarh 69 20 hot hot JJ cord-345222-otfnrarh 69 21 weather weather NN cord-345222-otfnrarh 69 22 . . . cord-345222-otfnrarh 70 1 19 19 CD cord-345222-otfnrarh 71 1 , , , cord-345222-otfnrarh 71 2 20 20 CD cord-345222-otfnrarh 71 3 • • NNS cord-345222-otfnrarh 72 1 Provision provision NN cord-345222-otfnrarh 72 2 of of IN cord-345222-otfnrarh 72 3 safe safe JJ cord-345222-otfnrarh 72 4 water water NN cord-345222-otfnrarh 72 5 for for IN cord-345222-otfnrarh 72 6 drinking drinking NN cord-345222-otfnrarh 72 7 and and CC cord-345222-otfnrarh 72 8 food food NN cord-345222-otfnrarh 72 9 preparation preparation NN cord-345222-otfnrarh 72 10 . . . cord-345222-otfnrarh 73 1 • • NNP cord-345222-otfnrarh 74 1 Proper proper JJ cord-345222-otfnrarh 74 2 hand hand NN cord-345222-otfnrarh 74 3 - - HYPH cord-345222-otfnrarh 74 4 washing wash VBG cord-345222-otfnrarh 74 5 hygiene hygiene NN cord-345222-otfnrarh 74 6 after after IN cord-345222-otfnrarh 74 7 toilet toilet NN cord-345222-otfnrarh 74 8 use use NN cord-345222-otfnrarh 74 9 and and CC cord-345222-otfnrarh 74 10 before before IN cord-345222-otfnrarh 74 11 food food NN cord-345222-otfnrarh 74 12 preparation preparation NN cord-345222-otfnrarh 74 13 and and CC cord-345222-otfnrarh 74 14 feeding feeding NN cord-345222-otfnrarh 74 15 . . . cord-345222-otfnrarh 75 1 • • NNP cord-345222-otfnrarh 76 1 Safe safe JJ cord-345222-otfnrarh 76 2 disposal disposal NN cord-345222-otfnrarh 76 3 of of IN cord-345222-otfnrarh 76 4 human human JJ cord-345222-otfnrarh 76 5 and and CC cord-345222-otfnrarh 76 6 other other JJ cord-345222-otfnrarh 76 7 waste waste NN cord-345222-otfnrarh 76 8 . . . cord-345222-otfnrarh 77 1 Table table NN cord-345222-otfnrarh 77 2 1A 1a NN cord-345222-otfnrarh 77 3 - - HYPH cord-345222-otfnrarh 77 4 C c NN cord-345222-otfnrarh 77 5 shows show VBZ cord-345222-otfnrarh 77 6 the the DT cord-345222-otfnrarh 77 7 main main JJ cord-345222-otfnrarh 77 8 characteristics characteristic NNS cord-345222-otfnrarh 77 9 of of IN cord-345222-otfnrarh 77 10 the the DT cord-345222-otfnrarh 77 11 principal principal JJ cord-345222-otfnrarh 77 12 bacterial bacterial JJ cord-345222-otfnrarh 77 13 , , , cord-345222-otfnrarh 77 14 viral viral JJ cord-345222-otfnrarh 77 15 , , , cord-345222-otfnrarh 77 16 fungal fungal JJ cord-345222-otfnrarh 77 17 , , , cord-345222-otfnrarh 77 18 and and CC cord-345222-otfnrarh 77 19 parasitic parasitic JJ cord-345222-otfnrarh 77 20 enteropathogens enteropathogen NNS cord-345222-otfnrarh 77 21 , , , cord-345222-otfnrarh 77 22 respectively respectively RB cord-345222-otfnrarh 77 23 : : : cord-345222-otfnrarh 77 24 typical typical JJ cord-345222-otfnrarh 77 25 age age NN cord-345222-otfnrarh 77 26 of of IN cord-345222-otfnrarh 77 27 presentation presentation NN cord-345222-otfnrarh 77 28 , , , cord-345222-otfnrarh 77 29 type type NN cord-345222-otfnrarh 77 30 of of IN cord-345222-otfnrarh 77 31 diarrhea diarrhea NN cord-345222-otfnrarh 77 32 , , , cord-345222-otfnrarh 77 33 duration duration NN cord-345222-otfnrarh 77 34 of of IN cord-345222-otfnrarh 77 35 symptoms symptom NNS cord-345222-otfnrarh 77 36 , , , cord-345222-otfnrarh 77 37 clinical clinical JJ cord-345222-otfnrarh 77 38 features feature NNS cord-345222-otfnrarh 77 39 , , , cord-345222-otfnrarh 77 40 transmission transmission NN cord-345222-otfnrarh 77 41 , , , cord-345222-otfnrarh 77 42 and and CC cord-345222-otfnrarh 77 43 seasonality seasonality NN cord-345222-otfnrarh 77 44 . . . cord-345222-otfnrarh 78 1 not not RB cord-345222-otfnrarh 78 2 always always RB cord-345222-otfnrarh 78 3 well well RB cord-345222-otfnrarh 78 4 defined define VBN cord-345222-otfnrarh 78 5 , , , cord-345222-otfnrarh 78 6 because because IN cord-345222-otfnrarh 78 7 some some DT cord-345222-otfnrarh 78 8 agents agent NNS cord-345222-otfnrarh 78 9 use use VBP cord-345222-otfnrarh 78 10 both both CC cord-345222-otfnrarh 78 11 these these DT cord-345222-otfnrarh 78 12 pathogenetic pathogenetic JJ cord-345222-otfnrarh 78 13 strategies strategy NNS cord-345222-otfnrarh 78 14 to to TO cord-345222-otfnrarh 78 15 induce induce VB cord-345222-otfnrarh 78 16 disease disease NN cord-345222-otfnrarh 78 17 . . . cord-345222-otfnrarh 79 1 In in IN cord-345222-otfnrarh 79 2 Europe Europe NNP cord-345222-otfnrarh 79 3 , , , cord-345222-otfnrarh 79 4 the the DT cord-345222-otfnrarh 79 5 most most RBS cord-345222-otfnrarh 79 6 common common JJ cord-345222-otfnrarh 79 7 bacterial bacterial JJ cord-345222-otfnrarh 79 8 agent agent NN cord-345222-otfnrarh 79 9 is be VBZ cord-345222-otfnrarh 79 10 either either CC cord-345222-otfnrarh 79 11 Salmonella Salmonella NNP cord-345222-otfnrarh 79 12 or or CC cord-345222-otfnrarh 79 13 Campylobacter Campylobacter NNP cord-345222-otfnrarh 79 14 , , , cord-345222-otfnrarh 79 15 depending depend VBG cord-345222-otfnrarh 79 16 on on IN cord-345222-otfnrarh 79 17 country country NN cord-345222-otfnrarh 79 18 . . . cord-345222-otfnrarh 80 1 6 6 CD cord-345222-otfnrarh 80 2 Aeromonas Aeromonas NNP cord-345222-otfnrarh 80 3 hydrophila hydrophila NN cord-345222-otfnrarh 80 4 and and CC cord-345222-otfnrarh 80 5 Plesiomonas Plesiomonas NNP cord-345222-otfnrarh 80 6 shigelloides shigelloide NNS cord-345222-otfnrarh 80 7 ( ( -LRB- cord-345222-otfnrarh 80 8 previously previously RB cord-345222-otfnrarh 80 9 also also RB cord-345222-otfnrarh 80 10 known know VBN cord-345222-otfnrarh 80 11 as as IN cord-345222-otfnrarh 80 12 Aeromonas Aeromonas NNP cord-345222-otfnrarh 80 13 shigelloides shigelloide NNS cord-345222-otfnrarh 80 14 ) ) -RRB- cord-345222-otfnrarh 80 15 belonging belong VBG cord-345222-otfnrarh 80 16 to to IN cord-345222-otfnrarh 80 17 the the DT cord-345222-otfnrarh 80 18 family family NN cord-345222-otfnrarh 80 19 of of IN cord-345222-otfnrarh 80 20 Vibronacee Vibronacee NNP cord-345222-otfnrarh 80 21 , , , cord-345222-otfnrarh 80 22 can can MD cord-345222-otfnrarh 80 23 cause cause VB cord-345222-otfnrarh 80 24 watery watery JJ cord-345222-otfnrarh 80 25 diarrhea diarrhea NN cord-345222-otfnrarh 80 26 . . . cord-345222-otfnrarh 81 1 The the DT cord-345222-otfnrarh 81 2 pathogenic pathogenic JJ cord-345222-otfnrarh 81 3 role role NN cord-345222-otfnrarh 81 4 of of IN cord-345222-otfnrarh 81 5 A. a. NN cord-345222-otfnrarh 81 6 hydrophila hydrophila NN cord-345222-otfnrarh 81 7 as as IN cord-345222-otfnrarh 81 8 an an DT cord-345222-otfnrarh 81 9 enteric enteric JJ cord-345222-otfnrarh 81 10 pathogen pathogen NN cord-345222-otfnrarh 81 11 causing cause VBG cord-345222-otfnrarh 81 12 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 81 13 is be VBZ cord-345222-otfnrarh 81 14 difficult difficult JJ cord-345222-otfnrarh 81 15 to to TO cord-345222-otfnrarh 81 16 confirm confirm VB cord-345222-otfnrarh 81 17 , , , cord-345222-otfnrarh 81 18 because because IN cord-345222-otfnrarh 81 19 of of IN cord-345222-otfnrarh 81 20 the the DT cord-345222-otfnrarh 81 21 frequency frequency NN cord-345222-otfnrarh 81 22 of of IN cord-345222-otfnrarh 81 23 other other JJ cord-345222-otfnrarh 81 24 pathogens pathogen NNS cord-345222-otfnrarh 81 25 isolated isolate VBN cord-345222-otfnrarh 81 26 with with IN cord-345222-otfnrarh 81 27 A. a. NN cord-345222-otfnrarh 81 28 hydrophila hydrophila NN cord-345222-otfnrarh 81 29 in in IN cord-345222-otfnrarh 81 30 symptomatic symptomatic JJ cord-345222-otfnrarh 81 31 and and CC cord-345222-otfnrarh 81 32 asymptomatic asymptomatic JJ cord-345222-otfnrarh 81 33 subjects subject NNS cord-345222-otfnrarh 81 34 . . . cord-345222-otfnrarh 82 1 But but CC cord-345222-otfnrarh 82 2 A. A. NNP cord-345222-otfnrarh 82 3 hydrophila hydrophila NN cord-345222-otfnrarh 82 4 is be VBZ cord-345222-otfnrarh 82 5 recognized recognize VBN cord-345222-otfnrarh 82 6 increasingly increasingly RB cord-345222-otfnrarh 82 7 as as IN cord-345222-otfnrarh 82 8 a a DT cord-345222-otfnrarh 82 9 clinically clinically RB cord-345222-otfnrarh 82 10 significant significant JJ cord-345222-otfnrarh 82 11 enteric enteric JJ cord-345222-otfnrarh 82 12 pathogen pathogen NN cord-345222-otfnrarh 82 13 associated associate VBN cord-345222-otfnrarh 82 14 with with IN cord-345222-otfnrarh 82 15 diarrhea diarrhea NN cord-345222-otfnrarh 82 16 also also RB cord-345222-otfnrarh 82 17 in in IN cord-345222-otfnrarh 82 18 children child NNS cord-345222-otfnrarh 82 19 younger young JJR cord-345222-otfnrarh 82 20 than than IN cord-345222-otfnrarh 82 21 2 2 CD cord-345222-otfnrarh 82 22 years year NNS cord-345222-otfnrarh 82 23 of of IN cord-345222-otfnrarh 82 24 age age NN cord-345222-otfnrarh 82 25 living live VBG cord-345222-otfnrarh 82 26 in in IN cord-345222-otfnrarh 82 27 a a DT cord-345222-otfnrarh 82 28 rural rural JJ cord-345222-otfnrarh 82 29 community community NN cord-345222-otfnrarh 82 30 , , , cord-345222-otfnrarh 82 31 and and CC cord-345222-otfnrarh 82 32 is be VBZ cord-345222-otfnrarh 82 33 linked link VBN cord-345222-otfnrarh 82 34 to to IN cord-345222-otfnrarh 82 35 local local JJ cord-345222-otfnrarh 82 36 drinking drinking NN cord-345222-otfnrarh 82 37 water water NN cord-345222-otfnrarh 82 38 sources source NNS cord-345222-otfnrarh 82 39 . . . cord-345222-otfnrarh 83 1 21 21 CD cord-345222-otfnrarh 84 1 Campylobacter Campylobacter NNP cord-345222-otfnrarh 84 2 is be VBZ cord-345222-otfnrarh 84 3 the the DT cord-345222-otfnrarh 84 4 most most RBS cord-345222-otfnrarh 84 5 common common JJ cord-345222-otfnrarh 84 6 enteropathogen enteropathogen NN cord-345222-otfnrarh 84 7 after after IN cord-345222-otfnrarh 84 8 5 5 CD cord-345222-otfnrarh 84 9 years year NNS cord-345222-otfnrarh 84 10 of of IN cord-345222-otfnrarh 84 11 age age NN cord-345222-otfnrarh 84 12 , , , cord-345222-otfnrarh 84 13 particularly particularly RB cord-345222-otfnrarh 84 14 in in IN cord-345222-otfnrarh 84 15 Northern northern JJ cord-345222-otfnrarh 84 16 European european JJ cord-345222-otfnrarh 84 17 countries country NNS cord-345222-otfnrarh 84 18 . . . cord-345222-otfnrarh 85 1 6 6 CD cord-345222-otfnrarh 85 2 C. C. NNP cord-345222-otfnrarh 85 3 jejuni jejuni NNP cord-345222-otfnrarh 85 4 and and CC cord-345222-otfnrarh 85 5 C. C. NNP cord-345222-otfnrarh 85 6 coli coli VBZ cord-345222-otfnrarh 85 7 infections infection NNS cord-345222-otfnrarh 85 8 are be VBP cord-345222-otfnrarh 85 9 endemic endemic JJ cord-345222-otfnrarh 85 10 worldwide worldwide JJ cord-345222-otfnrarh 85 11 and and CC cord-345222-otfnrarh 85 12 hyperendemic hyperendemic NN cord-345222-otfnrarh 85 13 in in IN cord-345222-otfnrarh 85 14 resource resource NN cord-345222-otfnrarh 85 15 - - HYPH cord-345222-otfnrarh 85 16 constrained constrain VBN cord-345222-otfnrarh 85 17 nations nation NNS cord-345222-otfnrarh 85 18 . . . cord-345222-otfnrarh 86 1 Infants infant NNS cord-345222-otfnrarh 86 2 and and CC cord-345222-otfnrarh 86 3 young young JJ cord-345222-otfnrarh 86 4 adults adult NNS cord-345222-otfnrarh 86 5 are be VBP cord-345222-otfnrarh 86 6 most most RBS cord-345222-otfnrarh 86 7 often often RB cord-345222-otfnrarh 86 8 infected infect VBN cord-345222-otfnrarh 86 9 . . . cord-345222-otfnrarh 87 1 22 22 CD cord-345222-otfnrarh 87 2 C. C. NNP cord-345222-otfnrarh 87 3 jejuni jejuni NNP cord-345222-otfnrarh 87 4 , , , cord-345222-otfnrarh 87 5 followed follow VBN cord-345222-otfnrarh 87 6 by by IN cord-345222-otfnrarh 87 7 C. C. NNP cord-345222-otfnrarh 87 8 coli coli NNS cord-345222-otfnrarh 87 9 and and CC cord-345222-otfnrarh 87 10 C. C. NNP cord-345222-otfnrarh 87 11 lari lari NNP cord-345222-otfnrarh 87 12 , , , cord-345222-otfnrarh 87 13 are be VBP cord-345222-otfnrarh 87 14 the the DT cord-345222-otfnrarh 87 15 most most RBS cord-345222-otfnrarh 87 16 common common JJ cord-345222-otfnrarh 87 17 bacterial bacterial JJ cord-345222-otfnrarh 87 18 causes cause NNS cord-345222-otfnrarh 87 19 of of IN cord-345222-otfnrarh 87 20 acute acute JJ cord-345222-otfnrarh 87 21 diarrheal diarrheal JJ cord-345222-otfnrarh 87 22 illnesses illness NNS cord-345222-otfnrarh 87 23 in in IN cord-345222-otfnrarh 87 24 rich rich JJ cord-345222-otfnrarh 87 25 nations nation NNS cord-345222-otfnrarh 87 26 . . . cord-345222-otfnrarh 88 1 22 22 CD cord-345222-otfnrarh 88 2 C. C. NNP cord-345222-otfnrarh 88 3 jejuni jejuni NNP cord-345222-otfnrarh 88 4 has have VBZ cord-345222-otfnrarh 88 5 invasive invasive JJ cord-345222-otfnrarh 88 6 properties property NNS cord-345222-otfnrarh 88 7 , , , cord-345222-otfnrarh 88 8 leading lead VBG cord-345222-otfnrarh 88 9 to to IN cord-345222-otfnrarh 88 10 epithelial epithelial JJ cord-345222-otfnrarh 88 11 ulceration ulceration NN cord-345222-otfnrarh 88 12 and and CC cord-345222-otfnrarh 88 13 inflammatory inflammatory JJ cord-345222-otfnrarh 88 14 infiltrates infiltrate NNS cord-345222-otfnrarh 88 15 in in IN cord-345222-otfnrarh 88 16 the the DT cord-345222-otfnrarh 88 17 lamina lamina JJ cord-345222-otfnrarh 88 18 propria propria NN cord-345222-otfnrarh 88 19 , , , cord-345222-otfnrarh 88 20 mainly mainly RB cord-345222-otfnrarh 88 21 in in IN cord-345222-otfnrarh 88 22 the the DT cord-345222-otfnrarh 88 23 colon colon NN cord-345222-otfnrarh 88 24 , , , cord-345222-otfnrarh 88 25 ileum ileum NN cord-345222-otfnrarh 88 26 , , , cord-345222-otfnrarh 88 27 and and CC cord-345222-otfnrarh 88 28 jejunum jejunum NNS cord-345222-otfnrarh 88 29 . . . cord-345222-otfnrarh 89 1 Some some DT cord-345222-otfnrarh 89 2 C. C. NNP cord-345222-otfnrarh 89 3 jejuni jejuni NNP cord-345222-otfnrarh 89 4 isolates isolate VBZ cord-345222-otfnrarh 89 5 elaborate elaborate VBP cord-345222-otfnrarh 89 6 very very RB cord-345222-otfnrarh 89 7 low low JJ cord-345222-otfnrarh 89 8 levels level NNS cord-345222-otfnrarh 89 9 of of IN cord-345222-otfnrarh 89 10 cytotoxins cytotoxin NNS cord-345222-otfnrarh 89 11 , , , cord-345222-otfnrarh 89 12 similar similar JJ cord-345222-otfnrarh 89 13 to to IN cord-345222-otfnrarh 89 14 Shiga Shiga NNP cord-345222-otfnrarh 89 15 toxin toxin NN cord-345222-otfnrarh 89 16 . . . cord-345222-otfnrarh 90 1 Some some DT cord-345222-otfnrarh 90 2 isolates isolate NNS cord-345222-otfnrarh 90 3 have have VBP cord-345222-otfnrarh 90 4 been be VBN cord-345222-otfnrarh 90 5 reported report VBN cord-345222-otfnrarh 90 6 to to TO cord-345222-otfnrarh 90 7 elaborate elaborate VB cord-345222-otfnrarh 90 8 an an DT cord-345222-otfnrarh 90 9 enterotoxin enterotoxin NN cord-345222-otfnrarh 90 10 similar similar JJ cord-345222-otfnrarh 90 11 to to IN cord-345222-otfnrarh 90 12 cholera cholera NN cord-345222-otfnrarh 90 13 toxin toxin NN cord-345222-otfnrarh 90 14 . . . cord-345222-otfnrarh 91 1 Enterotoxin Enterotoxin NNP cord-345222-otfnrarh 91 2 production production NN cord-345222-otfnrarh 91 3 has have VBZ cord-345222-otfnrarh 91 4 been be VBN cord-345222-otfnrarh 91 5 more more RBR cord-345222-otfnrarh 91 6 frequently frequently RB cord-345222-otfnrarh 91 7 observed observe VBN cord-345222-otfnrarh 91 8 in in IN cord-345222-otfnrarh 91 9 isolates isolate NNS cord-345222-otfnrarh 91 10 from from IN cord-345222-otfnrarh 91 11 resource resource NN cord-345222-otfnrarh 91 12 - - HYPH cord-345222-otfnrarh 91 13 constrained constrain VBN cord-345222-otfnrarh 91 14 nations nation NNS cord-345222-otfnrarh 91 15 , , , cord-345222-otfnrarh 91 16 where where WRB cord-345222-otfnrarh 91 17 infection infection NN cord-345222-otfnrarh 91 18 by by IN cord-345222-otfnrarh 91 19 C. C. NNP cord-345222-otfnrarh 91 20 jejuni jejuni NNP cord-345222-otfnrarh 91 21 has have VBZ cord-345222-otfnrarh 91 22 been be VBN cord-345222-otfnrarh 91 23 associated associate VBN cord-345222-otfnrarh 91 24 with with IN cord-345222-otfnrarh 91 25 watery watery JJ cord-345222-otfnrarh 91 26 diarrhea diarrhea NN cord-345222-otfnrarh 91 27 . . . cord-345222-otfnrarh 92 1 However however RB cord-345222-otfnrarh 92 2 , , , cord-345222-otfnrarh 92 3 the the DT cord-345222-otfnrarh 92 4 clinical clinical JJ cord-345222-otfnrarh 92 5 significance significance NN cord-345222-otfnrarh 92 6 of of IN cord-345222-otfnrarh 92 7 the the DT cord-345222-otfnrarh 92 8 toxigenicity toxigenicity NN cord-345222-otfnrarh 92 9 of of IN cord-345222-otfnrarh 92 10 these these DT cord-345222-otfnrarh 92 11 organisms organism NNS cord-345222-otfnrarh 92 12 is be VBZ cord-345222-otfnrarh 92 13 still still RB cord-345222-otfnrarh 92 14 unclear unclear JJ cord-345222-otfnrarh 92 15 . . . cord-345222-otfnrarh 93 1 23 23 CD cord-345222-otfnrarh 93 2 Symptoms symptom NNS cord-345222-otfnrarh 93 3 and and CC cord-345222-otfnrarh 93 4 signs sign NNS cord-345222-otfnrarh 93 5 of of IN cord-345222-otfnrarh 93 6 C. C. NNP cord-345222-otfnrarh 93 7 enteritis enteritis NN cord-345222-otfnrarh 93 8 are be VBP cord-345222-otfnrarh 93 9 not not RB cord-345222-otfnrarh 93 10 distinctive distinctive JJ cord-345222-otfnrarh 93 11 enough enough RB cord-345222-otfnrarh 93 12 to to TO cord-345222-otfnrarh 93 13 differentiate differentiate VB cord-345222-otfnrarh 93 14 it -PRON- PRP cord-345222-otfnrarh 93 15 from from IN cord-345222-otfnrarh 93 16 illness illness NN cord-345222-otfnrarh 93 17 caused cause VBN cord-345222-otfnrarh 93 18 by by IN cord-345222-otfnrarh 93 19 many many JJ cord-345222-otfnrarh 93 20 other other JJ cord-345222-otfnrarh 93 21 enteric enteric JJ cord-345222-otfnrarh 93 22 pathogens pathogen NNS cord-345222-otfnrarh 93 23 . . . cord-345222-otfnrarh 94 1 Diarrhea diarrhea NN cord-345222-otfnrarh 94 2 is be VBZ cord-345222-otfnrarh 94 3 often often RB cord-345222-otfnrarh 94 4 associated associate VBN cord-345222-otfnrarh 94 5 with with IN cord-345222-otfnrarh 94 6 blood blood NN cord-345222-otfnrarh 94 7 , , , cord-345222-otfnrarh 94 8 but but CC cord-345222-otfnrarh 94 9 it -PRON- PRP cord-345222-otfnrarh 94 10 can can MD cord-345222-otfnrarh 94 11 be be VB cord-345222-otfnrarh 94 12 difficult difficult JJ cord-345222-otfnrarh 94 13 to to TO cord-345222-otfnrarh 94 14 distinguish distinguish VB cord-345222-otfnrarh 94 15 from from IN cord-345222-otfnrarh 94 16 other other JJ cord-345222-otfnrarh 94 17 invasive invasive JJ cord-345222-otfnrarh 94 18 forms form NNS cord-345222-otfnrarh 94 19 . . . cord-345222-otfnrarh 95 1 A a DT cord-345222-otfnrarh 95 2 cholera cholera NN cord-345222-otfnrarh 95 3 - - HYPH cord-345222-otfnrarh 95 4 like like JJ cord-345222-otfnrarh 95 5 illness illness NN cord-345222-otfnrarh 95 6 with with IN cord-345222-otfnrarh 95 7 massive massive JJ cord-345222-otfnrarh 95 8 watery watery JJ cord-345222-otfnrarh 95 9 diarrhea diarrhea NN cord-345222-otfnrarh 95 10 may may MD cord-345222-otfnrarh 95 11 also also RB cord-345222-otfnrarh 95 12 occur occur VB cord-345222-otfnrarh 95 13 . . . cord-345222-otfnrarh 96 1 Bacteremia Bacteremia NNP cord-345222-otfnrarh 96 2 is be VBZ cord-345222-otfnrarh 96 3 uncommon uncommon JJ cord-345222-otfnrarh 96 4 ( ( -LRB- cord-345222-otfnrarh 96 5 less less JJR cord-345222-otfnrarh 96 6 than than IN cord-345222-otfnrarh 96 7 1 1 CD cord-345222-otfnrarh 96 8 % % NN cord-345222-otfnrarh 96 9 ) ) -RRB- cord-345222-otfnrarh 96 10 in in IN cord-345222-otfnrarh 96 11 immunocompetent immunocompetent JJ cord-345222-otfnrarh 96 12 patients patient NNS cord-345222-otfnrarh 96 13 with with IN cord-345222-otfnrarh 96 14 C. C. NNP cord-345222-otfnrarh 96 15 jejuni jejuni NNP cord-345222-otfnrarh 96 16 infection infection NN cord-345222-otfnrarh 96 17 . . . cord-345222-otfnrarh 97 1 22 22 CD cord-345222-otfnrarh 97 2 Newborn newborn JJ cord-345222-otfnrarh 97 3 infection infection NN cord-345222-otfnrarh 97 4 by by IN cord-345222-otfnrarh 97 5 Campylobacter Campylobacter NNP cord-345222-otfnrarh 97 6 spp spp NNS cord-345222-otfnrarh 97 7 is be VBZ cord-345222-otfnrarh 97 8 rare rare JJ cord-345222-otfnrarh 97 9 ; ; : cord-345222-otfnrarh 97 10 most most JJS cord-345222-otfnrarh 97 11 cases case NNS cord-345222-otfnrarh 97 12 were be VBD cord-345222-otfnrarh 97 13 born bear VBN cord-345222-otfnrarh 97 14 to to IN cord-345222-otfnrarh 97 15 mothers mother NNS cord-345222-otfnrarh 97 16 with with IN cord-345222-otfnrarh 97 17 Campylobacter Campylobacter NNP cord-345222-otfnrarh 97 18 diarrhea diarrhea NN cord-345222-otfnrarh 97 19 at at IN cord-345222-otfnrarh 97 20 the the DT cord-345222-otfnrarh 97 21 time time NN cord-345222-otfnrarh 97 22 of of IN cord-345222-otfnrarh 97 23 delivery delivery NN cord-345222-otfnrarh 97 24 . . . cord-345222-otfnrarh 98 1 The the DT cord-345222-otfnrarh 98 2 transplacental transplacental JJ cord-345222-otfnrarh 98 3 passage passage NN cord-345222-otfnrarh 98 4 of of IN cord-345222-otfnrarh 98 5 Campylobacter Campylobacter NNP cord-345222-otfnrarh 98 6 fetus fetus NN cord-345222-otfnrarh 98 7 is be VBZ cord-345222-otfnrarh 98 8 responsible responsible JJ cord-345222-otfnrarh 98 9 for for IN cord-345222-otfnrarh 98 10 abortion abortion NN cord-345222-otfnrarh 98 11 , , , cord-345222-otfnrarh 98 12 premature premature JJ cord-345222-otfnrarh 98 13 birth birth NN cord-345222-otfnrarh 98 14 , , , cord-345222-otfnrarh 98 15 bacteremia bacteremia NN cord-345222-otfnrarh 98 16 , , , cord-345222-otfnrarh 98 17 and and CC cord-345222-otfnrarh 98 18 meningitis meningitis NN cord-345222-otfnrarh 98 19 . . . cord-345222-otfnrarh 99 1 C. C. NNP cord-345222-otfnrarh 99 2 jejuni jejuni NNP cord-345222-otfnrarh 99 3 / / SYM cord-345222-otfnrarh 99 4 coli coli VBZ cord-345222-otfnrarh 99 5 infections infection NNS cord-345222-otfnrarh 99 6 can can MD cord-345222-otfnrarh 99 7 cause cause VB cord-345222-otfnrarh 99 8 a a DT cord-345222-otfnrarh 99 9 series series NN cord-345222-otfnrarh 99 10 of of IN cord-345222-otfnrarh 99 11 complications complication NNS cord-345222-otfnrarh 99 12 as as IN cord-345222-otfnrarh 99 13 reactive reactive JJ cord-345222-otfnrarh 99 14 arthritis arthritis NN cord-345222-otfnrarh 99 15 , , , cord-345222-otfnrarh 99 16 irritable irritable JJ cord-345222-otfnrarh 99 17 bowel bowel NN cord-345222-otfnrarh 99 18 syndrome syndrome NN cord-345222-otfnrarh 99 19 , , , cord-345222-otfnrarh 99 20 and and CC cord-345222-otfnrarh 99 21 Guillain Guillain NNP cord-345222-otfnrarh 99 22 - - HYPH cord-345222-otfnrarh 99 23 Barré Barré NNP cord-345222-otfnrarh 99 24 Syndrome Syndrome NNP cord-345222-otfnrarh 99 25 ( ( -LRB- cord-345222-otfnrarh 99 26 GBS GBS NNP cord-345222-otfnrarh 99 27 ) ) -RRB- cord-345222-otfnrarh 99 28 , , , cord-345222-otfnrarh 99 29 an an DT cord-345222-otfnrarh 99 30 acute acute JJ cord-345222-otfnrarh 99 31 neurologic neurologic JJ cord-345222-otfnrarh 99 32 disease disease NN cord-345222-otfnrarh 99 33 driven drive VBN cord-345222-otfnrarh 99 34 by by IN cord-345222-otfnrarh 99 35 autoimmunity autoimmunity NN cord-345222-otfnrarh 99 36 and and CC cord-345222-otfnrarh 99 37 molecular molecular JJ cord-345222-otfnrarh 99 38 mimicry mimicry NN cord-345222-otfnrarh 99 39 in in IN cord-345222-otfnrarh 99 40 which which WDT cord-345222-otfnrarh 99 41 the the DT cord-345222-otfnrarh 99 42 body body NN cord-345222-otfnrarh 99 43 stages stage VBZ cord-345222-otfnrarh 99 44 a a DT cord-345222-otfnrarh 99 45 cell cell NN cord-345222-otfnrarh 99 46 - - HYPH cord-345222-otfnrarh 99 47 mediated mediate VBN cord-345222-otfnrarh 99 48 and and CC cord-345222-otfnrarh 99 49 humoral humoral JJ cord-345222-otfnrarh 99 50 immunological immunological JJ cord-345222-otfnrarh 99 51 response response NN cord-345222-otfnrarh 99 52 against against IN cord-345222-otfnrarh 99 53 peripheral peripheral JJ cord-345222-otfnrarh 99 54 nerve nerve NN cord-345222-otfnrarh 99 55 myelin myelin NN cord-345222-otfnrarh 99 56 . . . cord-345222-otfnrarh 100 1 A a DT cord-345222-otfnrarh 100 2 recent recent JJ cord-345222-otfnrarh 100 3 systematic systematic JJ cord-345222-otfnrarh 100 4 review review NN cord-345222-otfnrarh 100 5 of of IN cord-345222-otfnrarh 100 6 GBS GBS NNP cord-345222-otfnrarh 100 7 estimated estimate VBD cord-345222-otfnrarh 100 8 that that IN cord-345222-otfnrarh 100 9 40%-70 40%-70 CD cord-345222-otfnrarh 100 10 % % NN cord-345222-otfnrarh 100 11 of of IN cord-345222-otfnrarh 100 12 all all DT cord-345222-otfnrarh 100 13 cases case NNS cord-345222-otfnrarh 100 14 are be VBP cord-345222-otfnrarh 100 15 preceded precede VBN cord-345222-otfnrarh 100 16 by by IN cord-345222-otfnrarh 100 17 an an DT cord-345222-otfnrarh 100 18 acute acute JJ cord-345222-otfnrarh 100 19 infectious infectious JJ cord-345222-otfnrarh 100 20 illness illness NN cord-345222-otfnrarh 100 21 , , , cord-345222-otfnrarh 100 22 of of IN cord-345222-otfnrarh 100 23 which which WDT cord-345222-otfnrarh 100 24 22%-53 22%-53 CD cord-345222-otfnrarh 100 25 % % NN cord-345222-otfnrarh 100 26 are be VBP cord-345222-otfnrarh 100 27 upper upper JJ cord-345222-otfnrarh 100 28 respiratory respiratory JJ cord-345222-otfnrarh 100 29 infections infection NNS cord-345222-otfnrarh 100 30 and and CC cord-345222-otfnrarh 100 31 6%-26 6%-26 CD cord-345222-otfnrarh 100 32 % % NN cord-345222-otfnrarh 100 33 are be VBP cord-345222-otfnrarh 100 34 gastrointestinal gastrointestinal JJ cord-345222-otfnrarh 100 35 infections infection NNS cord-345222-otfnrarh 100 36 , , , cord-345222-otfnrarh 100 37 one one CD cord-345222-otfnrarh 100 38 of of IN cord-345222-otfnrarh 100 39 the the DT cord-345222-otfnrarh 100 40 most most RBS cord-345222-otfnrarh 100 41 common common JJ cord-345222-otfnrarh 100 42 being be VBG cord-345222-otfnrarh 100 43 enteritis enteritis NN cord-345222-otfnrarh 100 44 due due IN cord-345222-otfnrarh 100 45 to to IN cord-345222-otfnrarh 100 46 Campylobacter Campylobacter NNP cord-345222-otfnrarh 100 47 . . . cord-345222-otfnrarh 101 1 24 24 CD cord-345222-otfnrarh 102 1 , , , cord-345222-otfnrarh 102 2 25 25 CD cord-345222-otfnrarh 102 3 Several several JJ cord-345222-otfnrarh 102 4 studies study NNS cord-345222-otfnrarh 102 5 have have VBP cord-345222-otfnrarh 102 6 shown show VBN cord-345222-otfnrarh 102 7 that that IN cord-345222-otfnrarh 102 8 patients patient NNS cord-345222-otfnrarh 102 9 with with IN cord-345222-otfnrarh 102 10 GBS GBS NNP cord-345222-otfnrarh 102 11 ( ( -LRB- cord-345222-otfnrarh 102 12 most most JJS cord-345222-otfnrarh 102 13 of of IN cord-345222-otfnrarh 102 14 cases case NNS cord-345222-otfnrarh 102 15 associated associate VBN cord-345222-otfnrarh 102 16 with with IN cord-345222-otfnrarh 102 17 the the DT cord-345222-otfnrarh 102 18 variant variant JJ cord-345222-otfnrarh 102 19 acute acute JJ cord-345222-otfnrarh 102 20 motor motor NN cord-345222-otfnrarh 102 21 axonal axonal JJ cord-345222-otfnrarh 102 22 neuropathy neuropathy NN cord-345222-otfnrarh 102 23 ) ) -RRB- cord-345222-otfnrarh 102 24 have have VBP cord-345222-otfnrarh 102 25 a a DT cord-345222-otfnrarh 102 26 recent recent JJ cord-345222-otfnrarh 102 27 history history NN cord-345222-otfnrarh 102 28 of of IN cord-345222-otfnrarh 102 29 infection infection NN cord-345222-otfnrarh 102 30 due due IN cord-345222-otfnrarh 102 31 to to IN cord-345222-otfnrarh 102 32 C. C. NNP cord-345222-otfnrarh 102 33 jejuni jejuni NNP cord-345222-otfnrarh 102 34 . . . cord-345222-otfnrarh 103 1 26 26 CD cord-345222-otfnrarh 103 2 Clostridium clostridium NN cord-345222-otfnrarh 103 3 difficile difficile NN cord-345222-otfnrarh 103 4 is be VBZ cord-345222-otfnrarh 103 5 a a DT cord-345222-otfnrarh 103 6 major major JJ cord-345222-otfnrarh 103 7 nosocomial nosocomial JJ cord-345222-otfnrarh 103 8 pathogen pathogen NN cord-345222-otfnrarh 103 9 that that WDT cord-345222-otfnrarh 103 10 causes cause VBZ cord-345222-otfnrarh 103 11 a a DT cord-345222-otfnrarh 103 12 spectrum spectrum NN cord-345222-otfnrarh 103 13 of of IN cord-345222-otfnrarh 103 14 intestinal intestinal JJ cord-345222-otfnrarh 103 15 disease disease NN cord-345222-otfnrarh 103 16 from from IN cord-345222-otfnrarh 103 17 uncomplicated uncomplicated JJ cord-345222-otfnrarh 103 18 antibiotic antibiotic JJ cord-345222-otfnrarh 103 19 - - HYPH cord-345222-otfnrarh 103 20 associated associated JJ cord-345222-otfnrarh 103 21 diarrhea diarrhea NN cord-345222-otfnrarh 103 22 to to IN cord-345222-otfnrarh 103 23 severe severe JJ cord-345222-otfnrarh 103 24 , , , cord-345222-otfnrarh 103 25 possibly possibly RB cord-345222-otfnrarh 103 26 fatal fatal JJ cord-345222-otfnrarh 103 27 , , , cord-345222-otfnrarh 103 28 antibiotic antibiotic JJ cord-345222-otfnrarh 103 29 - - HYPH cord-345222-otfnrarh 103 30 associated associate VBN cord-345222-otfnrarh 103 31 colitis colitis NN cord-345222-otfnrarh 103 32 . . . cord-345222-otfnrarh 104 1 27 27 CD cord-345222-otfnrarh 105 1 In in IN cord-345222-otfnrarh 105 2 the the DT cord-345222-otfnrarh 105 3 last last JJ cord-345222-otfnrarh 105 4 5 5 CD cord-345222-otfnrarh 105 5 - - SYM cord-345222-otfnrarh 105 6 7 7 CD cord-345222-otfnrarh 105 7 years year NNS cord-345222-otfnrarh 105 8 , , , cord-345222-otfnrarh 105 9 a a DT cord-345222-otfnrarh 105 10 change change NN cord-345222-otfnrarh 105 11 in in IN cord-345222-otfnrarh 105 12 the the DT cord-345222-otfnrarh 105 13 epidemiologic epidemiologic JJ cord-345222-otfnrarh 105 14 pattern pattern NN cord-345222-otfnrarh 105 15 of of IN cord-345222-otfnrarh 105 16 C. C. NNP cord-345222-otfnrarh 105 17 difficile difficile NN cord-345222-otfnrarh 105 18 infection infection NN cord-345222-otfnrarh 105 19 characterized characterize VBN cord-345222-otfnrarh 105 20 by by IN cord-345222-otfnrarh 105 21 an an DT cord-345222-otfnrarh 105 22 increasing increase VBG cord-345222-otfnrarh 105 23 incidence incidence NN cord-345222-otfnrarh 105 24 and and CC cord-345222-otfnrarh 105 25 severity severity NN cord-345222-otfnrarh 105 26 of of IN cord-345222-otfnrarh 105 27 infection infection NN cord-345222-otfnrarh 105 28 has have VBZ cord-345222-otfnrarh 105 29 been be VBN cord-345222-otfnrarh 105 30 observed observe VBN cord-345222-otfnrarh 105 31 . . . cord-345222-otfnrarh 106 1 A a DT cord-345222-otfnrarh 106 2 few few JJ cord-345222-otfnrarh 106 3 epidemiological epidemiological JJ cord-345222-otfnrarh 106 4 studies study NNS cord-345222-otfnrarh 106 5 recently recently RB cord-345222-otfnrarh 106 6 conducted conduct VBN cord-345222-otfnrarh 106 7 in in IN cord-345222-otfnrarh 106 8 the the DT cord-345222-otfnrarh 106 9 pediatric pediatric JJ cord-345222-otfnrarh 106 10 population population NN cord-345222-otfnrarh 106 11 demonstrated demonstrate VBD cord-345222-otfnrarh 106 12 a a DT cord-345222-otfnrarh 106 13 twofold twofold JJ cord-345222-otfnrarh 106 14 increase increase NN cord-345222-otfnrarh 106 15 in in IN cord-345222-otfnrarh 106 16 the the DT cord-345222-otfnrarh 106 17 incidence incidence NN cord-345222-otfnrarh 106 18 of of IN cord-345222-otfnrarh 106 19 C. C. NNP cord-345222-otfnrarh 106 20 difficile difficile NN cord-345222-otfnrarh 106 21 infection infection NN cord-345222-otfnrarh 106 22 in in IN cord-345222-otfnrarh 106 23 the the DT cord-345222-otfnrarh 106 24 last last JJ cord-345222-otfnrarh 106 25 5 5 CD cord-345222-otfnrarh 106 26 years year NNS cord-345222-otfnrarh 106 27 , , , cord-345222-otfnrarh 106 28 but but CC cord-345222-otfnrarh 106 29 with with IN cord-345222-otfnrarh 106 30 no no DT cord-345222-otfnrarh 106 31 increase increase NN cord-345222-otfnrarh 106 32 in in IN cord-345222-otfnrarh 106 33 the the DT cord-345222-otfnrarh 106 34 incidence incidence NN cord-345222-otfnrarh 106 35 of of IN cord-345222-otfnrarh 106 36 severe severe JJ cord-345222-otfnrarh 106 37 complications complication NNS cord-345222-otfnrarh 106 38 , , , cord-345222-otfnrarh 106 39 such such JJ cord-345222-otfnrarh 106 40 as as IN cord-345222-otfnrarh 106 41 the the DT cord-345222-otfnrarh 106 42 need need NN cord-345222-otfnrarh 106 43 for for IN cord-345222-otfnrarh 106 44 colectomy colectomy NN cord-345222-otfnrarh 106 45 or or CC cord-345222-otfnrarh 106 46 mortality mortality NN cord-345222-otfnrarh 106 47 . . . cord-345222-otfnrarh 107 1 28 28 CD cord-345222-otfnrarh 107 2 , , , cord-345222-otfnrarh 107 3 29 29 CD cord-345222-otfnrarh 108 1 The the DT cord-345222-otfnrarh 108 2 clinical clinical JJ cord-345222-otfnrarh 108 3 presentation presentation NN cord-345222-otfnrarh 108 4 of of IN cord-345222-otfnrarh 108 5 C. C. NNP cord-345222-otfnrarh 108 6 difficile difficile NN cord-345222-otfnrarh 108 7 - - HYPH cord-345222-otfnrarh 108 8 associated associate VBN cord-345222-otfnrarh 108 9 disease disease NN cord-345222-otfnrarh 108 10 can can MD cord-345222-otfnrarh 108 11 range range VB cord-345222-otfnrarh 108 12 from from IN cord-345222-otfnrarh 108 13 asymptomatic asymptomatic JJ cord-345222-otfnrarh 108 14 carriage carriage NN cord-345222-otfnrarh 108 15 in in IN cord-345222-otfnrarh 108 16 the the DT cord-345222-otfnrarh 108 17 gastrointestinal gastrointestinal JJ cord-345222-otfnrarh 108 18 tract tract NN cord-345222-otfnrarh 108 19 and and CC cord-345222-otfnrarh 108 20 mild mild JJ cord-345222-otfnrarh 108 21 diarrhea diarrhea NN cord-345222-otfnrarh 108 22 to to IN cord-345222-otfnrarh 108 23 potentially potentially RB cord-345222-otfnrarh 108 24 fatal fatal JJ cord-345222-otfnrarh 108 25 pseudomembranous pseudomembranous JJ cord-345222-otfnrarh 108 26 colitis colitis NN cord-345222-otfnrarh 108 27 . . . cord-345222-otfnrarh 109 1 30 30 CD cord-345222-otfnrarh 109 2 Diarrhea diarrhea NN cord-345222-otfnrarh 109 3 is be VBZ cord-345222-otfnrarh 109 4 watery watery JJ cord-345222-otfnrarh 109 5 and and CC cord-345222-otfnrarh 109 6 usually usually RB cord-345222-otfnrarh 109 7 nonbloody nonbloody NNP cord-345222-otfnrarh 109 8 , , , cord-345222-otfnrarh 109 9 but but CC cord-345222-otfnrarh 109 10 approximately approximately RB cord-345222-otfnrarh 109 11 5%-10 5%-10 CD cord-345222-otfnrarh 109 12 % % NN cord-345222-otfnrarh 109 13 of of IN cord-345222-otfnrarh 109 14 patients patient NNS cord-345222-otfnrarh 109 15 have have VBP cord-345222-otfnrarh 109 16 bloody bloody JJ cord-345222-otfnrarh 109 17 diarrhea diarrhea NN cord-345222-otfnrarh 109 18 . . . cord-345222-otfnrarh 110 1 Fecal fecal JJ cord-345222-otfnrarh 110 2 material material NN cord-345222-otfnrarh 110 3 typically typically RB cord-345222-otfnrarh 110 4 contains contain VBZ cord-345222-otfnrarh 110 5 excess excess JJ cord-345222-otfnrarh 110 6 mucus mucus NN cord-345222-otfnrarh 110 7 , , , cord-345222-otfnrarh 110 8 and and CC cord-345222-otfnrarh 110 9 pus pus NN cord-345222-otfnrarh 110 10 or or CC cord-345222-otfnrarh 110 11 blood blood NN cord-345222-otfnrarh 110 12 may may MD cord-345222-otfnrarh 110 13 also also RB cord-345222-otfnrarh 110 14 be be VB cord-345222-otfnrarh 110 15 noted note VBN cord-345222-otfnrarh 110 16 . . . cord-345222-otfnrarh 111 1 31 31 CD cord-345222-otfnrarh 112 1 The the DT cord-345222-otfnrarh 112 2 disease disease NN cord-345222-otfnrarh 112 3 may may MD cord-345222-otfnrarh 112 4 progress progress VB cord-345222-otfnrarh 112 5 to to IN cord-345222-otfnrarh 112 6 a a DT cord-345222-otfnrarh 112 7 pseudomembranous pseudomembranous JJ cord-345222-otfnrarh 112 8 colitis colitis NN cord-345222-otfnrarh 112 9 , , , cord-345222-otfnrarh 112 10 possibly possibly RB cord-345222-otfnrarh 112 11 including include VBG cord-345222-otfnrarh 112 12 intestinal intestinal JJ cord-345222-otfnrarh 112 13 perforation perforation NN cord-345222-otfnrarh 112 14 and and CC cord-345222-otfnrarh 112 15 toxic toxic JJ cord-345222-otfnrarh 112 16 megacolon megacolon NN cord-345222-otfnrarh 112 17 . . . cord-345222-otfnrarh 113 1 Neonatal neonatal JJ cord-345222-otfnrarh 113 2 infections infection NNS cord-345222-otfnrarh 113 3 by by IN cord-345222-otfnrarh 113 4 C. C. NNP cord-345222-otfnrarh 113 5 difficile difficile NN cord-345222-otfnrarh 113 6 can can MD cord-345222-otfnrarh 113 7 be be VB cord-345222-otfnrarh 113 8 asymptomatic asymptomatic JJ cord-345222-otfnrarh 113 9 , , , cord-345222-otfnrarh 113 10 but but CC cord-345222-otfnrarh 113 11 usually usually RB cord-345222-otfnrarh 113 12 display display VBP cord-345222-otfnrarh 113 13 fever fever NN cord-345222-otfnrarh 113 14 , , , cord-345222-otfnrarh 113 15 diarrhea diarrhea NN cord-345222-otfnrarh 113 16 , , , cord-345222-otfnrarh 113 17 and and CC cord-345222-otfnrarh 113 18 irritability irritability NN cord-345222-otfnrarh 113 19 within within IN cord-345222-otfnrarh 113 20 48 48 CD cord-345222-otfnrarh 113 21 hours hour NNS cord-345222-otfnrarh 113 22 after after IN cord-345222-otfnrarh 113 23 production production NN cord-345222-otfnrarh 113 24 of of IN cord-345222-otfnrarh 113 25 the the DT cord-345222-otfnrarh 113 26 toxins toxin NNS cord-345222-otfnrarh 113 27 . . . cord-345222-otfnrarh 114 1 32 32 CD cord-345222-otfnrarh 114 2 Escherichia escherichia NN cord-345222-otfnrarh 114 3 coli coli NNS cord-345222-otfnrarh 114 4 are be VBP cord-345222-otfnrarh 114 5 the the DT cord-345222-otfnrarh 114 6 predominant predominant JJ cord-345222-otfnrarh 114 7 nonpathogenic nonpathogenic JJ cord-345222-otfnrarh 114 8 facultative facultative JJ cord-345222-otfnrarh 114 9 anaerobe anaerobe NN cord-345222-otfnrarh 114 10 of of IN cord-345222-otfnrarh 114 11 human human JJ cord-345222-otfnrarh 114 12 colonic colonic JJ cord-345222-otfnrarh 114 13 flora flora NNS cord-345222-otfnrarh 114 14 and and CC cord-345222-otfnrarh 114 15 usually usually RB cord-345222-otfnrarh 114 16 remain remain VBP cord-345222-otfnrarh 114 17 harmlessly harmlessly RB cord-345222-otfnrarh 114 18 confined confine VBN cord-345222-otfnrarh 114 19 to to IN cord-345222-otfnrarh 114 20 the the DT cord-345222-otfnrarh 114 21 intestinal intestinal JJ cord-345222-otfnrarh 114 22 lumen lumen NN cord-345222-otfnrarh 114 23 . . . cord-345222-otfnrarh 115 1 Some some DT cord-345222-otfnrarh 115 2 E. E. NNP cord-345222-otfnrarh 115 3 coli coli NNS cord-345222-otfnrarh 115 4 have have VBP cord-345222-otfnrarh 115 5 evolved evolve VBN cord-345222-otfnrarh 115 6 the the DT cord-345222-otfnrarh 115 7 ability ability NN cord-345222-otfnrarh 115 8 to to TO cord-345222-otfnrarh 115 9 cause cause VB cord-345222-otfnrarh 115 10 a a DT cord-345222-otfnrarh 115 11 broad broad JJ cord-345222-otfnrarh 115 12 spectrum spectrum NN cord-345222-otfnrarh 115 13 of of IN cord-345222-otfnrarh 115 14 human human JJ cord-345222-otfnrarh 115 15 diseases disease NNS cord-345222-otfnrarh 115 16 , , , cord-345222-otfnrarh 115 17 and and CC cord-345222-otfnrarh 115 18 different different JJ cord-345222-otfnrarh 115 19 types type NNS cord-345222-otfnrarh 115 20 associated associate VBN cord-345222-otfnrarh 115 21 with with IN cord-345222-otfnrarh 115 22 enteric enteric JJ cord-345222-otfnrarh 115 23 infections infection NNS cord-345222-otfnrarh 115 24 are be VBP cord-345222-otfnrarh 115 25 classified classify VBN cord-345222-otfnrarh 115 26 into into IN cord-345222-otfnrarh 115 27 five five CD cord-345222-otfnrarh 115 28 groups group NNS cord-345222-otfnrarh 115 29 according accord VBG cord-345222-otfnrarh 115 30 to to IN cord-345222-otfnrarh 115 31 their -PRON- PRP$ cord-345222-otfnrarh 115 32 virulence virulence NN cord-345222-otfnrarh 115 33 properties property NNS cord-345222-otfnrarh 115 34 and and CC cord-345222-otfnrarh 115 35 are be VBP cord-345222-otfnrarh 115 36 briefly briefly RB cord-345222-otfnrarh 115 37 described describe VBN cord-345222-otfnrarh 115 38 here here RB cord-345222-otfnrarh 115 39 . . . cord-345222-otfnrarh 116 1 Enteroaggregative Enteroaggregative NNP cord-345222-otfnrarh 116 2 E. E. NNP cord-345222-otfnrarh 116 3 coli coli NNS cord-345222-otfnrarh 116 4 ( ( -LRB- cord-345222-otfnrarh 116 5 EAEC EAEC NNP cord-345222-otfnrarh 116 6 ) ) -RRB- cord-345222-otfnrarh 116 7 serotypes serotype NNS cord-345222-otfnrarh 116 8 exhibit exhibit VBP cord-345222-otfnrarh 116 9 a a DT cord-345222-otfnrarh 116 10 characteristic characteristic JJ cord-345222-otfnrarh 116 11 aggregative aggregative JJ cord-345222-otfnrarh 116 12 pattern pattern NN cord-345222-otfnrarh 116 13 of of IN cord-345222-otfnrarh 116 14 adherence adherence NN cord-345222-otfnrarh 116 15 and and CC cord-345222-otfnrarh 116 16 produce produce VB cord-345222-otfnrarh 116 17 persistent persistent JJ cord-345222-otfnrarh 116 18 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 116 19 and and CC cord-345222-otfnrarh 116 20 diarrhea diarrhea NN cord-345222-otfnrarh 116 21 in in IN cord-345222-otfnrarh 116 22 infants infant NNS cord-345222-otfnrarh 116 23 and and CC cord-345222-otfnrarh 116 24 children child NNS cord-345222-otfnrarh 116 25 in in IN cord-345222-otfnrarh 116 26 resource resource NN cord-345222-otfnrarh 116 27 - - HYPH cord-345222-otfnrarh 116 28 constrained constrain VBN cord-345222-otfnrarh 116 29 nations nation NNS cord-345222-otfnrarh 116 30 . . . cord-345222-otfnrarh 117 1 22 22 CD cord-345222-otfnrarh 118 1 Enteroinvasive enteroinvasive JJ cord-345222-otfnrarh 118 2 E. E. NNP cord-345222-otfnrarh 118 3 coli coli NNS cord-345222-otfnrarh 118 4 serotypes serotype NNS cord-345222-otfnrarh 118 5 have have VBP cord-345222-otfnrarh 118 6 properties property NNS cord-345222-otfnrarh 118 7 similar similar JJ cord-345222-otfnrarh 118 8 to to IN cord-345222-otfnrarh 118 9 invasive invasive JJ cord-345222-otfnrarh 118 10 Salmonella Salmonella NNP cord-345222-otfnrarh 118 11 , , , cord-345222-otfnrarh 118 12 but but CC cord-345222-otfnrarh 118 13 the the DT cord-345222-otfnrarh 118 14 presence presence NN cord-345222-otfnrarh 118 15 of of IN cord-345222-otfnrarh 118 16 blood blood NN cord-345222-otfnrarh 118 17 in in IN cord-345222-otfnrarh 118 18 the the DT cord-345222-otfnrarh 118 19 stool stool NN cord-345222-otfnrarh 118 20 is be VBZ cord-345222-otfnrarh 118 21 less less RBR cord-345222-otfnrarh 118 22 frequent frequent JJ cord-345222-otfnrarh 118 23 . . . cord-345222-otfnrarh 119 1 These these DT cord-345222-otfnrarh 119 2 can can MD cord-345222-otfnrarh 119 3 also also RB cord-345222-otfnrarh 119 4 produce produce VB cord-345222-otfnrarh 119 5 an an DT cord-345222-otfnrarh 119 6 enterotoxin enterotoxin NN cord-345222-otfnrarh 119 7 that that WDT cord-345222-otfnrarh 119 8 cause cause VBP cord-345222-otfnrarh 119 9 watery watery JJ cord-345222-otfnrarh 119 10 diarrhea diarrhea NN cord-345222-otfnrarh 119 11 , , , cord-345222-otfnrarh 119 12 resembling resemble VBG cord-345222-otfnrarh 119 13 the the DT cord-345222-otfnrarh 119 14 effects effect NNS cord-345222-otfnrarh 119 15 of of IN cord-345222-otfnrarh 119 16 Shigella Shigella NNP cord-345222-otfnrarh 119 17 in in IN cord-345222-otfnrarh 119 18 children child NNS cord-345222-otfnrarh 119 19 and and CC cord-345222-otfnrarh 119 20 adults adult NNS cord-345222-otfnrarh 119 21 . . . cord-345222-otfnrarh 120 1 Enteropathogenic Enteropathogenic NNP cord-345222-otfnrarh 120 2 E. E. NNP cord-345222-otfnrarh 120 3 coli coli NNS cord-345222-otfnrarh 120 4 ( ( -LRB- cord-345222-otfnrarh 120 5 EPEC EPEC NNP cord-345222-otfnrarh 120 6 ) ) -RRB- cord-345222-otfnrarh 120 7 serotypes serotype NNS cord-345222-otfnrarh 120 8 in in IN cord-345222-otfnrarh 120 9 the the DT cord-345222-otfnrarh 120 10 past past NN cord-345222-otfnrarh 120 11 were be VBD cord-345222-otfnrarh 120 12 33 33 CD cord-345222-otfnrarh 120 13 Serotypes Serotypes NNP cord-345222-otfnrarh 120 14 number number NN cord-345222-otfnrarh 120 15 about about RB cord-345222-otfnrarh 120 16 50 50 CD cord-345222-otfnrarh 120 17 , , , cord-345222-otfnrarh 120 18 and and CC cord-345222-otfnrarh 120 19 in in IN cord-345222-otfnrarh 120 20 rich rich JJ cord-345222-otfnrarh 120 21 countries country NNS cord-345222-otfnrarh 120 22 are be VBP cord-345222-otfnrarh 120 23 primarily primarily RB cord-345222-otfnrarh 120 24 responsible responsible JJ cord-345222-otfnrarh 120 25 for for IN cord-345222-otfnrarh 120 26 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 120 27 with with IN cord-345222-otfnrarh 120 28 bloody bloody JJ cord-345222-otfnrarh 120 29 diarrhea diarrhea NN cord-345222-otfnrarh 120 30 , , , cord-345222-otfnrarh 120 31 severe severe JJ cord-345222-otfnrarh 120 32 abdominal abdominal JJ cord-345222-otfnrarh 120 33 pain pain NN cord-345222-otfnrarh 120 34 , , , cord-345222-otfnrarh 120 35 and and CC cord-345222-otfnrarh 120 36 cramps cramp NNS cord-345222-otfnrarh 120 37 that that WDT cord-345222-otfnrarh 120 38 resolve resolve VBP cord-345222-otfnrarh 120 39 in in IN cord-345222-otfnrarh 120 40 a a DT cord-345222-otfnrarh 120 41 few few JJ cord-345222-otfnrarh 120 42 days day NNS cord-345222-otfnrarh 120 43 with with IN cord-345222-otfnrarh 120 44 an an DT cord-345222-otfnrarh 120 45 adequate adequate JJ cord-345222-otfnrarh 120 46 oral oral JJ cord-345222-otfnrarh 120 47 rehydration rehydration NN cord-345222-otfnrarh 120 48 . . . cord-345222-otfnrarh 121 1 Since since IN cord-345222-otfnrarh 121 2 1982 1982 CD cord-345222-otfnrarh 121 3 , , , cord-345222-otfnrarh 121 4 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 121 5 from from IN cord-345222-otfnrarh 121 6 Shiga Shiga NNP cord-345222-otfnrarh 121 7 toxin toxin NN cord-345222-otfnrarh 121 8 - - HYPH cord-345222-otfnrarh 121 9 producing produce VBG cord-345222-otfnrarh 121 10 E. E. NNP cord-345222-otfnrarh 121 11 coli coli NNS cord-345222-otfnrarh 121 12 ( ( -LRB- cord-345222-otfnrarh 121 13 STEC STEC NNP cord-345222-otfnrarh 121 14 ) ) -RRB- cord-345222-otfnrarh 121 15 , , , cord-345222-otfnrarh 121 16 an an DT cord-345222-otfnrarh 121 17 E. E. NNP cord-345222-otfnrarh 121 18 coli coli NNS cord-345222-otfnrarh 121 19 strain strain NN cord-345222-otfnrarh 121 20 with with IN cord-345222-otfnrarh 121 21 the the DT cord-345222-otfnrarh 121 22 capacity capacity NN cord-345222-otfnrarh 121 23 to to TO cord-345222-otfnrarh 121 24 produce produce VB cord-345222-otfnrarh 121 25 a a DT cord-345222-otfnrarh 121 26 cytotoxin cytotoxin NN cord-345222-otfnrarh 121 27 similar similar JJ cord-345222-otfnrarh 121 28 to to IN cord-345222-otfnrarh 121 29 that that DT cord-345222-otfnrarh 121 30 produced produce VBN cord-345222-otfnrarh 121 31 by by IN cord-345222-otfnrarh 121 32 Shigella Shigella NNP cord-345222-otfnrarh 121 33 spp spp NNS cord-345222-otfnrarh 121 34 , , , cord-345222-otfnrarh 121 35 has have VBZ cord-345222-otfnrarh 121 36 been be VBN cord-345222-otfnrarh 121 37 identified identify VBN cord-345222-otfnrarh 121 38 as as IN cord-345222-otfnrarh 121 39 a a DT cord-345222-otfnrarh 121 40 significant significant JJ cord-345222-otfnrarh 121 41 health health NN cord-345222-otfnrarh 121 42 problem problem NN cord-345222-otfnrarh 121 43 in in IN cord-345222-otfnrarh 121 44 the the DT cord-345222-otfnrarh 121 45 developed develop VBN cord-345222-otfnrarh 121 46 world world NN cord-345222-otfnrarh 121 47 . . . cord-345222-otfnrarh 122 1 34 34 CD cord-345222-otfnrarh 122 2 , , , cord-345222-otfnrarh 122 3 35 35 CD cord-345222-otfnrarh 122 4 Infections infection NNS cord-345222-otfnrarh 122 5 with with IN cord-345222-otfnrarh 122 6 STEC STEC NNP cord-345222-otfnrarh 122 7 , , , cord-345222-otfnrarh 122 8 of of IN cord-345222-otfnrarh 122 9 which which WDT cord-345222-otfnrarh 122 10 EHEC EHEC NNP cord-345222-otfnrarh 122 11 O157 O157 NNP cord-345222-otfnrarh 122 12 is be VBZ cord-345222-otfnrarh 122 13 the the DT cord-345222-otfnrarh 122 14 most most RBS cord-345222-otfnrarh 122 15 well well RB cord-345222-otfnrarh 122 16 - - HYPH cord-345222-otfnrarh 122 17 known know VBN cord-345222-otfnrarh 122 18 serotype serotype NN cord-345222-otfnrarh 122 19 , , , cord-345222-otfnrarh 122 20 have have VBP cord-345222-otfnrarh 122 21 been be VBN cord-345222-otfnrarh 122 22 recorded record VBN cord-345222-otfnrarh 122 23 in in IN cord-345222-otfnrarh 122 24 many many JJ cord-345222-otfnrarh 122 25 regions region NNS cord-345222-otfnrarh 122 26 , , , cord-345222-otfnrarh 122 27 including include VBG cord-345222-otfnrarh 122 28 North North NNP cord-345222-otfnrarh 122 29 America America NNP cord-345222-otfnrarh 122 30 , , , cord-345222-otfnrarh 122 31 Western Western NNP cord-345222-otfnrarh 122 32 Europe Europe NNP cord-345222-otfnrarh 122 33 , , , cord-345222-otfnrarh 122 34 Central Central NNP cord-345222-otfnrarh 122 35 and and CC cord-345222-otfnrarh 122 36 South South NNP cord-345222-otfnrarh 122 37 America America NNP cord-345222-otfnrarh 122 38 , , , cord-345222-otfnrarh 122 39 the the DT cord-345222-otfnrarh 122 40 Middle Middle NNP cord-345222-otfnrarh 122 41 and and CC cord-345222-otfnrarh 122 42 Far Far NNP cord-345222-otfnrarh 122 43 East East NNP cord-345222-otfnrarh 122 44 , , , cord-345222-otfnrarh 122 45 Africa Africa NNP cord-345222-otfnrarh 122 46 and and CC cord-345222-otfnrarh 122 47 Australia Australia NNP cord-345222-otfnrarh 122 48 ; ; : cord-345222-otfnrarh 122 49 also also RB cord-345222-otfnrarh 122 50 , , , cord-345222-otfnrarh 122 51 EAEC EAEC NNP cord-345222-otfnrarh 122 52 serotype serotype NN cord-345222-otfnrarh 122 53 O104 o104 CD cord-345222-otfnrarh 122 54 : : : cord-345222-otfnrarh 123 1 H4 H4 NNP cord-345222-otfnrarh 123 2 can can MD cord-345222-otfnrarh 123 3 produce produce VB cord-345222-otfnrarh 123 4 Shiga Shiga NNP cord-345222-otfnrarh 123 5 toxins toxin NNS cord-345222-otfnrarh 123 6 ( ( -LRB- cord-345222-otfnrarh 123 7 STEC STEC NNP cord-345222-otfnrarh 123 8 ) ) -RRB- cord-345222-otfnrarh 123 9 . . . cord-345222-otfnrarh 124 1 [ [ -LRB- cord-345222-otfnrarh 124 2 36 36 CD cord-345222-otfnrarh 124 3 ] ] -RRB- cord-345222-otfnrarh 124 4 [ [ -LRB- cord-345222-otfnrarh 124 5 37 37 CD cord-345222-otfnrarh 124 6 ] ] -RRB- cord-345222-otfnrarh 124 7 [ [ -LRB- cord-345222-otfnrarh 124 8 38 38 CD cord-345222-otfnrarh 124 9 ] ] -RRB- cord-345222-otfnrarh 125 1 Infections infection NNS cord-345222-otfnrarh 125 2 by by IN cord-345222-otfnrarh 125 3 STEC STEC NNP cord-345222-otfnrarh 125 4 are be VBP cord-345222-otfnrarh 125 5 characterized characterize VBN cord-345222-otfnrarh 125 6 by by IN cord-345222-otfnrarh 125 7 abdominal abdominal JJ cord-345222-otfnrarh 125 8 cramps cramp NNS cord-345222-otfnrarh 125 9 and and CC cord-345222-otfnrarh 125 10 acute acute JJ cord-345222-otfnrarh 125 11 bloody bloody JJ cord-345222-otfnrarh 125 12 diarrhea diarrhea NN cord-345222-otfnrarh 125 13 ; ; : cord-345222-otfnrarh 125 14 39 39 CD cord-345222-otfnrarh 125 15 however however RB cord-345222-otfnrarh 125 16 , , , cord-345222-otfnrarh 125 17 more more RBR cord-345222-otfnrarh 125 18 serious serious JJ cord-345222-otfnrarh 125 19 sequelae sequela NNS cord-345222-otfnrarh 125 20 may may MD cord-345222-otfnrarh 125 21 also also RB cord-345222-otfnrarh 125 22 result result VB cord-345222-otfnrarh 125 23 , , , cord-345222-otfnrarh 125 24 including include VBG cord-345222-otfnrarh 125 25 hemolytic hemolytic JJ cord-345222-otfnrarh 125 26 uremic uremic JJ cord-345222-otfnrarh 125 27 syndrome syndrome NN cord-345222-otfnrarh 125 28 ( ( -LRB- cord-345222-otfnrarh 125 29 HUS HUS NNP cord-345222-otfnrarh 125 30 ) ) -RRB- cord-345222-otfnrarh 125 31 , , , cord-345222-otfnrarh 125 32 thrombocytopenia thrombocytopenia NN cord-345222-otfnrarh 125 33 , , , cord-345222-otfnrarh 125 34 and and CC cord-345222-otfnrarh 125 35 associated associated JJ cord-345222-otfnrarh 125 36 complications complication NNS cord-345222-otfnrarh 125 37 , , , cord-345222-otfnrarh 125 38 which which WDT cord-345222-otfnrarh 125 39 can can MD cord-345222-otfnrarh 125 40 lead lead VB cord-345222-otfnrarh 125 41 to to IN cord-345222-otfnrarh 125 42 kidney kidney NN cord-345222-otfnrarh 125 43 failure failure NN cord-345222-otfnrarh 125 44 and and CC cord-345222-otfnrarh 125 45 death death NN cord-345222-otfnrarh 125 46 in in IN cord-345222-otfnrarh 125 47 some some DT cord-345222-otfnrarh 125 48 individuals individual NNS cord-345222-otfnrarh 125 49 . . . cord-345222-otfnrarh 126 1 36 36 CD cord-345222-otfnrarh 126 2 , , , cord-345222-otfnrarh 126 3 40 40 CD cord-345222-otfnrarh 126 4 Most Most JJS cord-345222-otfnrarh 126 5 outbreaks outbreak NNS cord-345222-otfnrarh 126 6 and and CC cord-345222-otfnrarh 126 7 sporadic sporadic JJ cord-345222-otfnrarh 126 8 cases case NNS cord-345222-otfnrarh 126 9 of of IN cord-345222-otfnrarh 126 10 bloody bloody JJ cord-345222-otfnrarh 126 11 diarrhea diarrhea NN cord-345222-otfnrarh 126 12 and and CC cord-345222-otfnrarh 126 13 HUS HUS NNP cord-345222-otfnrarh 126 14 have have VBP cord-345222-otfnrarh 126 15 been be VBN cord-345222-otfnrarh 126 16 attributed attribute VBN cord-345222-otfnrarh 126 17 to to IN cord-345222-otfnrarh 126 18 strains strain NNS cord-345222-otfnrarh 126 19 of of IN cord-345222-otfnrarh 126 20 STEC STEC NNP cord-345222-otfnrarh 126 21 serotype serotype NN cord-345222-otfnrarh 126 22 O157 O157 NNP cord-345222-otfnrarh 126 23 : : : cord-345222-otfnrarh 126 24 H7 H7 NNP cord-345222-otfnrarh 126 25 . . . cord-345222-otfnrarh 127 1 However however RB cord-345222-otfnrarh 127 2 , , , cord-345222-otfnrarh 127 3 in in IN cord-345222-otfnrarh 127 4 Europe Europe NNP cord-345222-otfnrarh 127 5 and and CC cord-345222-otfnrarh 127 6 recently recently RB cord-345222-otfnrarh 127 7 in in IN cord-345222-otfnrarh 127 8 the the DT cord-345222-otfnrarh 127 9 US US NNP cord-345222-otfnrarh 127 10 , , , cord-345222-otfnrarh 127 11 the the DT cord-345222-otfnrarh 127 12 role role NN cord-345222-otfnrarh 127 13 of of IN cord-345222-otfnrarh 127 14 non non JJ cord-345222-otfnrarh 127 15 - - JJ cord-345222-otfnrarh 127 16 O157 o157 JJ cord-345222-otfnrarh 127 17 STEC STEC NNP cord-345222-otfnrarh 127 18 strains strain NNS cord-345222-otfnrarh 127 19 ( ( -LRB- cord-345222-otfnrarh 127 20 eg eg IN cord-345222-otfnrarh 127 21 , , , cord-345222-otfnrarh 127 22 O26 O26 NNP cord-345222-otfnrarh 127 23 : : : cord-345222-otfnrarh 127 24 H11 H11 NNP cord-345222-otfnrarh 127 25 / / SYM cord-345222-otfnrarh 127 26 H- H- NNP cord-345222-otfnrarh 127 27 , , , cord-345222-otfnrarh 127 28 O91 O91 NNP cord-345222-otfnrarh 127 29 : : : cord-345222-otfnrarh 128 1 H21 H21 NNP cord-345222-otfnrarh 128 2 / / SYM cord-345222-otfnrarh 128 3 H- H- NNP cord-345222-otfnrarh 128 4 , , , cord-345222-otfnrarh 128 5 O103 o103 CD cord-345222-otfnrarh 128 6 : : : cord-345222-otfnrarh 128 7 H2 H2 NNP cord-345222-otfnrarh 128 8 , , , cord-345222-otfnrarh 128 9 O104 o104 CD cord-345222-otfnrarh 128 10 : : : cord-345222-otfnrarh 128 11 H4 H4 NNP cord-345222-otfnrarh 128 12 , , , cord-345222-otfnrarh 129 1 O111 o111 NN cord-345222-otfnrarh 129 2 : : : cord-345222-otfnrarh 130 1 H- H- NNP cord-345222-otfnrarh 130 2 , , , cord-345222-otfnrarh 130 3 O111 o111 CD cord-345222-otfnrarh 130 4 : : : cord-345222-otfnrarh 130 5 NM NM NNP cord-345222-otfnrarh 130 6 , , , cord-345222-otfnrarh 130 7 O113 O113 NNS cord-345222-otfnrarh 130 8 : : : cord-345222-otfnrarh 130 9 H21 H21 NNP cord-345222-otfnrarh 130 10 , , , cord-345222-otfnrarh 130 11 O121 o121 CD cord-345222-otfnrarh 130 12 : : : cord-345222-otfnrarh 131 1 H19 H19 NNP cord-345222-otfnrarh 131 2 , , , cord-345222-otfnrarh 131 3 O128 O128 '' cord-345222-otfnrarh 131 4 : : : cord-345222-otfnrarh 131 5 H2 H2 NNP cord-345222-otfnrarh 131 6 / / SYM cord-345222-otfnrarh 131 7 H- H- NNP cord-345222-otfnrarh 131 8 , , , cord-345222-otfnrarh 131 9 and and CC cord-345222-otfnrarh 131 10 O145 o145 NN cord-345222-otfnrarh 131 11 : : : cord-345222-otfnrarh 132 1 H28 H28 NNP cord-345222-otfnrarh 132 2 / / SYM cord-345222-otfnrarh 132 3 H- H- NNP cord-345222-otfnrarh 132 4 ) ) -RRB- cord-345222-otfnrarh 133 1 as as IN cord-345222-otfnrarh 133 2 causes cause NNS cord-345222-otfnrarh 133 3 of of IN cord-345222-otfnrarh 133 4 HUS HUS NNP cord-345222-otfnrarh 133 5 , , , cord-345222-otfnrarh 133 6 bloody bloody JJ cord-345222-otfnrarh 133 7 diarrhea diarrhea NN cord-345222-otfnrarh 133 8 , , , cord-345222-otfnrarh 133 9 and and CC cord-345222-otfnrarh 133 10 other other JJ cord-345222-otfnrarh 133 11 gastrointestinal gastrointestinal JJ cord-345222-otfnrarh 133 12 illnesses illness NNS cord-345222-otfnrarh 133 13 is be VBZ cord-345222-otfnrarh 133 14 being be VBG cord-345222-otfnrarh 133 15 increasingly increasingly RB cord-345222-otfnrarh 133 16 recognized recognize VBN cord-345222-otfnrarh 133 17 . . . cord-345222-otfnrarh 134 1 33 33 CD cord-345222-otfnrarh 134 2 , , , cord-345222-otfnrarh 134 3 41 41 CD cord-345222-otfnrarh 135 1 In in IN cord-345222-otfnrarh 135 2 many many JJ cord-345222-otfnrarh 135 3 studies study NNS cord-345222-otfnrarh 135 4 , , , cord-345222-otfnrarh 135 5 a a DT cord-345222-otfnrarh 135 6 significant significant JJ cord-345222-otfnrarh 135 7 association association NN cord-345222-otfnrarh 135 8 between between IN cord-345222-otfnrarh 135 9 illness illness NN cord-345222-otfnrarh 135 10 and and CC cord-345222-otfnrarh 135 11 the the DT cord-345222-otfnrarh 135 12 consumption consumption NN cord-345222-otfnrarh 135 13 of of IN cord-345222-otfnrarh 135 14 pink pink JJ cord-345222-otfnrarh 135 15 or or CC cord-345222-otfnrarh 135 16 undercooked undercooked JJ cord-345222-otfnrarh 135 17 hamburgers hamburger NNS cord-345222-otfnrarh 135 18 , , , cord-345222-otfnrarh 135 19 pinkish pinkish JJ cord-345222-otfnrarh 135 20 ground ground NN cord-345222-otfnrarh 135 21 beef beef NN cord-345222-otfnrarh 135 22 , , , cord-345222-otfnrarh 135 23 undercooked undercooked JJ cord-345222-otfnrarh 135 24 meat meat NN cord-345222-otfnrarh 135 25 , , , cord-345222-otfnrarh 135 26 or or CC cord-345222-otfnrarh 135 27 barbecued barbecue VBN cord-345222-otfnrarh 135 28 food food NN cord-345222-otfnrarh 135 29 has have VBZ cord-345222-otfnrarh 135 30 been be VBN cord-345222-otfnrarh 135 31 demonstrated demonstrate VBN cord-345222-otfnrarh 135 32 . . . cord-345222-otfnrarh 136 1 38 38 CD cord-345222-otfnrarh 136 2 , , , cord-345222-otfnrarh 136 3 41 41 CD cord-345222-otfnrarh 136 4 , , , cord-345222-otfnrarh 136 5 42 42 CD cord-345222-otfnrarh 136 6 The the DT cord-345222-otfnrarh 136 7 natural natural JJ cord-345222-otfnrarh 136 8 reservoirs reservoir NNS cord-345222-otfnrarh 136 9 of of IN cord-345222-otfnrarh 136 10 STEC STEC NNP cord-345222-otfnrarh 136 11 are be VBP cord-345222-otfnrarh 136 12 ruminant ruminant NN cord-345222-otfnrarh 136 13 animals animal NNS cord-345222-otfnrarh 136 14 , , , cord-345222-otfnrarh 136 15 especially especially RB cord-345222-otfnrarh 136 16 cattle cattle NNS cord-345222-otfnrarh 136 17 , , , cord-345222-otfnrarh 136 18 and and CC cord-345222-otfnrarh 136 19 transmission transmission NN cord-345222-otfnrarh 136 20 to to IN cord-345222-otfnrarh 136 21 humans human NNS cord-345222-otfnrarh 136 22 usually usually RB cord-345222-otfnrarh 136 23 occurs occur VBZ cord-345222-otfnrarh 136 24 via via IN cord-345222-otfnrarh 136 25 contaminated contaminate VBN cord-345222-otfnrarh 136 26 food food NN cord-345222-otfnrarh 136 27 or or CC cord-345222-otfnrarh 136 28 water water NN cord-345222-otfnrarh 136 29 . . . cord-345222-otfnrarh 137 1 Helicobacter Helicobacter NNP cord-345222-otfnrarh 137 2 pylori pylori NN cord-345222-otfnrarh 137 3 ( ( -LRB- cord-345222-otfnrarh 138 1 previously previously RB cord-345222-otfnrarh 138 2 named name VBN cord-345222-otfnrarh 138 3 Campylobacter Campylobacter NNP cord-345222-otfnrarh 138 4 pyloridis)-infected pyloridis)-infecte VBN cord-345222-otfnrarh 138 5 children child NNS cord-345222-otfnrarh 138 6 may may MD cord-345222-otfnrarh 138 7 have have VB cord-345222-otfnrarh 138 8 no no DT cord-345222-otfnrarh 138 9 symptoms symptom NNS cord-345222-otfnrarh 138 10 or or CC cord-345222-otfnrarh 138 11 a a DT cord-345222-otfnrarh 138 12 wide wide JJ cord-345222-otfnrarh 138 13 variety variety NN cord-345222-otfnrarh 138 14 of of IN cord-345222-otfnrarh 138 15 symptoms symptom NNS cord-345222-otfnrarh 138 16 , , , cord-345222-otfnrarh 138 17 and and CC cord-345222-otfnrarh 138 18 rarely rarely RB cord-345222-otfnrarh 138 19 potentially potentially RB cord-345222-otfnrarh 138 20 life life NN cord-345222-otfnrarh 138 21 - - HYPH cord-345222-otfnrarh 138 22 threatening threaten VBG cord-345222-otfnrarh 138 23 complications complication NNS cord-345222-otfnrarh 138 24 , , , cord-345222-otfnrarh 138 25 such such JJ cord-345222-otfnrarh 138 26 as as IN cord-345222-otfnrarh 138 27 gastroduodenal gastroduodenal JJ cord-345222-otfnrarh 138 28 ulcers ulcer NNS cord-345222-otfnrarh 138 29 and and CC cord-345222-otfnrarh 138 30 bleeding bleed VBG cord-345222-otfnrarh 138 31 . . . cord-345222-otfnrarh 139 1 Symptoms symptom NNS cord-345222-otfnrarh 139 2 of of IN cord-345222-otfnrarh 139 3 ulcers ulcer NNS cord-345222-otfnrarh 139 4 may may MD cord-345222-otfnrarh 139 5 include include VB cord-345222-otfnrarh 139 6 pain pain NN cord-345222-otfnrarh 139 7 or or CC cord-345222-otfnrarh 139 8 discomfort discomfort NN cord-345222-otfnrarh 139 9 ( ( -LRB- cord-345222-otfnrarh 139 10 usually usually RB cord-345222-otfnrarh 139 11 in in IN cord-345222-otfnrarh 139 12 the the DT cord-345222-otfnrarh 139 13 upper upper JJ cord-345222-otfnrarh 139 14 abdomen abdomen NN cord-345222-otfnrarh 139 15 ) ) -RRB- cord-345222-otfnrarh 139 16 , , , cord-345222-otfnrarh 139 17 bloating bloating NN cord-345222-otfnrarh 139 18 , , , cord-345222-otfnrarh 139 19 an an DT cord-345222-otfnrarh 139 20 early early JJ cord-345222-otfnrarh 139 21 sense sense NN cord-345222-otfnrarh 139 22 of of IN cord-345222-otfnrarh 139 23 fullness fullness NN cord-345222-otfnrarh 139 24 with with IN cord-345222-otfnrarh 139 25 eating eating NN cord-345222-otfnrarh 139 26 , , , cord-345222-otfnrarh 139 27 lack lack NN cord-345222-otfnrarh 139 28 of of IN cord-345222-otfnrarh 139 29 appetite appetite NN cord-345222-otfnrarh 139 30 , , , cord-345222-otfnrarh 139 31 nausea nausea NN cord-345222-otfnrarh 139 32 , , , cord-345222-otfnrarh 139 33 vomiting vomiting NN cord-345222-otfnrarh 139 34 , , , cord-345222-otfnrarh 139 35 blood blood NN cord-345222-otfnrarh 139 36 in in IN cord-345222-otfnrarh 139 37 the the DT cord-345222-otfnrarh 139 38 stools stool NNS cord-345222-otfnrarh 139 39 , , , cord-345222-otfnrarh 139 40 and and CC cord-345222-otfnrarh 139 41 diarrhea diarrhea NN cord-345222-otfnrarh 139 42 . . . cord-345222-otfnrarh 140 1 In in IN cord-345222-otfnrarh 140 2 the the DT cord-345222-otfnrarh 140 3 last last JJ cord-345222-otfnrarh 140 4 10 10 CD cord-345222-otfnrarh 140 5 years year NNS cord-345222-otfnrarh 140 6 , , , cord-345222-otfnrarh 140 7 various various JJ cord-345222-otfnrarh 140 8 studies study NNS cord-345222-otfnrarh 140 9 have have VBP cord-345222-otfnrarh 140 10 been be VBN cord-345222-otfnrarh 140 11 performed perform VBN cord-345222-otfnrarh 140 12 investigating investigate VBG cord-345222-otfnrarh 140 13 its -PRON- PRP$ cord-345222-otfnrarh 140 14 role role NN cord-345222-otfnrarh 140 15 to to TO cord-345222-otfnrarh 140 16 modify modify VB cord-345222-otfnrarh 140 17 the the DT cord-345222-otfnrarh 140 18 susceptibility susceptibility NN cord-345222-otfnrarh 140 19 to to IN cord-345222-otfnrarh 140 20 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 140 21 in in IN cord-345222-otfnrarh 140 22 children child NNS cord-345222-otfnrarh 140 23 . . . cord-345222-otfnrarh 141 1 43 43 CD cord-345222-otfnrarh 142 1 A a DT cord-345222-otfnrarh 142 2 study study NN cord-345222-otfnrarh 142 3 reported report VBD cord-345222-otfnrarh 142 4 an an DT cord-345222-otfnrarh 142 5 increased increase VBN cord-345222-otfnrarh 142 6 risk risk NN cord-345222-otfnrarh 142 7 of of IN cord-345222-otfnrarh 142 8 chronic chronic JJ cord-345222-otfnrarh 142 9 diarrhea diarrhea NN cord-345222-otfnrarh 142 10 , , , cord-345222-otfnrarh 142 11 compared compare VBN cord-345222-otfnrarh 142 12 with with IN cord-345222-otfnrarh 142 13 healthy healthy JJ cord-345222-otfnrarh 142 14 control control NN cord-345222-otfnrarh 142 15 subjects subject NNS cord-345222-otfnrarh 142 16 , , , cord-345222-otfnrarh 142 17 among among IN cord-345222-otfnrarh 142 18 infected infected JJ cord-345222-otfnrarh 142 19 age age NN cord-345222-otfnrarh 142 20 - - HYPH cord-345222-otfnrarh 142 21 matched match VBN cord-345222-otfnrarh 142 22 Gambian gambian JJ cord-345222-otfnrarh 142 23 children child NNS cord-345222-otfnrarh 142 24 with with IN cord-345222-otfnrarh 142 25 malnutrition malnutrition NN cord-345222-otfnrarh 142 26 . . . cord-345222-otfnrarh 143 1 44 44 CD cord-345222-otfnrarh 144 1 In in IN cord-345222-otfnrarh 144 2 a a DT cord-345222-otfnrarh 144 3 nested nested JJ cord-345222-otfnrarh 144 4 case case NN cord-345222-otfnrarh 144 5 - - HYPH cord-345222-otfnrarh 144 6 control control NN cord-345222-otfnrarh 144 7 design design NN cord-345222-otfnrarh 144 8 , , , cord-345222-otfnrarh 144 9 the the DT cord-345222-otfnrarh 144 10 authors author NNS cord-345222-otfnrarh 144 11 found find VBD cord-345222-otfnrarh 144 12 an an DT cord-345222-otfnrarh 144 13 increased increase VBN cord-345222-otfnrarh 144 14 risk risk NN cord-345222-otfnrarh 144 15 of of IN cord-345222-otfnrarh 144 16 severe severe JJ cord-345222-otfnrarh 144 17 cholera cholera NN cord-345222-otfnrarh 144 18 among among IN cord-345222-otfnrarh 144 19 H. H. NNP cord-345222-otfnrarh 144 20 pylori pylori NN cord-345222-otfnrarh 144 21 - - HYPH cord-345222-otfnrarh 144 22 infected infect VBN cord-345222-otfnrarh 144 23 subjects subject NNS cord-345222-otfnrarh 144 24 without without IN cord-345222-otfnrarh 144 25 vibriocidal vibriocidal JJ cord-345222-otfnrarh 144 26 antibodies antibody NNS cord-345222-otfnrarh 144 27 . . . cord-345222-otfnrarh 145 1 45 45 CD cord-345222-otfnrarh 146 1 Similarly similarly RB cord-345222-otfnrarh 146 2 , , , cord-345222-otfnrarh 146 3 in in IN cord-345222-otfnrarh 146 4 an an DT cord-345222-otfnrarh 146 5 urban urban JJ cord-345222-otfnrarh 146 6 slum slum NN cord-345222-otfnrarh 146 7 , , , cord-345222-otfnrarh 146 8 H. H. NNP cord-345222-otfnrarh 146 9 pylori pylori NN cord-345222-otfnrarh 146 10 infection infection NN cord-345222-otfnrarh 146 11 was be VBD cord-345222-otfnrarh 146 12 twice twice RB cord-345222-otfnrarh 146 13 as as RB cord-345222-otfnrarh 146 14 common common JJ cord-345222-otfnrarh 146 15 among among IN cord-345222-otfnrarh 146 16 subjects subject NNS cord-345222-otfnrarh 146 17 with with IN cord-345222-otfnrarh 146 18 typhoid typhoid NN cord-345222-otfnrarh 146 19 fever fever NN cord-345222-otfnrarh 146 20 ( ( -LRB- cord-345222-otfnrarh 146 21 Salmonella Salmonella NNP cord-345222-otfnrarh 146 22 typhi typhi NNP cord-345222-otfnrarh 146 23 ) ) -RRB- cord-345222-otfnrarh 146 24 46 46 CD cord-345222-otfnrarh 146 25 than than IN cord-345222-otfnrarh 146 26 in in IN cord-345222-otfnrarh 146 27 neighborhood neighborhood NN cord-345222-otfnrarh 146 28 control control NN cord-345222-otfnrarh 146 29 subjects subject NNS cord-345222-otfnrarh 146 30 . . . cord-345222-otfnrarh 147 1 Another another DT cord-345222-otfnrarh 147 2 study study NN cord-345222-otfnrarh 147 3 reported report VBD cord-345222-otfnrarh 147 4 increased increase VBN cord-345222-otfnrarh 147 5 diarrhea diarrhea NN cord-345222-otfnrarh 147 6 episodes episode NNS cord-345222-otfnrarh 147 7 among among IN cord-345222-otfnrarh 147 8 Peruvian peruvian JJ cord-345222-otfnrarh 147 9 infants infant NNS cord-345222-otfnrarh 147 10 with with IN cord-345222-otfnrarh 147 11 recent recent JJ cord-345222-otfnrarh 147 12 H. h. NN cord-345222-otfnrarh 147 13 pylori pylori NN cord-345222-otfnrarh 147 14 seroconversion seroconversion NN cord-345222-otfnrarh 147 15 . . . cord-345222-otfnrarh 148 1 47 47 CD cord-345222-otfnrarh 148 2 Conversely conversely RB cord-345222-otfnrarh 148 3 , , , cord-345222-otfnrarh 148 4 in in IN cord-345222-otfnrarh 148 5 a a DT cord-345222-otfnrarh 148 6 Thai Thai NNP cord-345222-otfnrarh 148 7 orphanage orphanage NN cord-345222-otfnrarh 148 8 , , , cord-345222-otfnrarh 148 9 no no DT cord-345222-otfnrarh 148 10 association association NN cord-345222-otfnrarh 148 11 was be VBD cord-345222-otfnrarh 148 12 found find VBN cord-345222-otfnrarh 148 13 between between IN cord-345222-otfnrarh 148 14 seroconversion seroconversion NN cord-345222-otfnrarh 148 15 and and CC cord-345222-otfnrarh 148 16 diarrheal diarrheal JJ cord-345222-otfnrarh 148 17 disease disease NN cord-345222-otfnrarh 148 18 . . . cord-345222-otfnrarh 149 1 48 48 CD cord-345222-otfnrarh 150 1 Some some DT cord-345222-otfnrarh 150 2 investigators investigator NNS cord-345222-otfnrarh 150 3 have have VBP cord-345222-otfnrarh 150 4 even even RB cord-345222-otfnrarh 150 5 speculated speculate VBN cord-345222-otfnrarh 150 6 that that IN cord-345222-otfnrarh 150 7 local local JJ cord-345222-otfnrarh 150 8 inflammatory inflammatory JJ cord-345222-otfnrarh 150 9 factors factor NNS cord-345222-otfnrarh 150 10 induced induce VBN cord-345222-otfnrarh 150 11 by by IN cord-345222-otfnrarh 150 12 infection infection NN cord-345222-otfnrarh 150 13 may may MD cord-345222-otfnrarh 150 14 be be VB cord-345222-otfnrarh 150 15 protective protective JJ cord-345222-otfnrarh 150 16 . . . cord-345222-otfnrarh 151 1 49 49 CD cord-345222-otfnrarh 152 1 In in IN cord-345222-otfnrarh 152 2 a a DT cord-345222-otfnrarh 152 3 cross cross JJ cord-345222-otfnrarh 152 4 - - JJ cord-345222-otfnrarh 152 5 sectional sectional JJ cord-345222-otfnrarh 152 6 study study NN cord-345222-otfnrarh 152 7 of of IN cord-345222-otfnrarh 152 8 elementary elementary JJ cord-345222-otfnrarh 152 9 school school NN cord-345222-otfnrarh 152 10 - - HYPH cord-345222-otfnrarh 152 11 age age NN cord-345222-otfnrarh 152 12 children child NNS cord-345222-otfnrarh 152 13 in in IN cord-345222-otfnrarh 152 14 Germany Germany NNP cord-345222-otfnrarh 152 15 , , , cord-345222-otfnrarh 152 16 the the DT cord-345222-otfnrarh 152 17 infection infection NN cord-345222-otfnrarh 152 18 seemed seem VBD cord-345222-otfnrarh 152 19 associated associated JJ cord-345222-otfnrarh 152 20 with with IN cord-345222-otfnrarh 152 21 a a DT cord-345222-otfnrarh 152 22 reduced reduce VBN cord-345222-otfnrarh 152 23 frequency frequency NN cord-345222-otfnrarh 152 24 of of IN cord-345222-otfnrarh 152 25 diarrheal diarrheal JJ cord-345222-otfnrarh 152 26 illnesses illness NNS cord-345222-otfnrarh 152 27 . . . cord-345222-otfnrarh 153 1 50 50 CD cord-345222-otfnrarh 154 1 These these DT cord-345222-otfnrarh 154 2 epidemiological epidemiological JJ cord-345222-otfnrarh 154 3 discrepancies discrepancy NNS cord-345222-otfnrarh 154 4 could could MD cord-345222-otfnrarh 154 5 be be VB cord-345222-otfnrarh 154 6 explained explain VBN cord-345222-otfnrarh 154 7 , , , cord-345222-otfnrarh 154 8 because because IN cord-345222-otfnrarh 154 9 H. H. NNP cord-345222-otfnrarh 154 10 pylori pylori NN cord-345222-otfnrarh 154 11 could could MD cord-345222-otfnrarh 154 12 be be VB cord-345222-otfnrarh 154 13 argued argue VBN cord-345222-otfnrarh 154 14 to to TO cord-345222-otfnrarh 154 15 increase increase VB cord-345222-otfnrarh 154 16 or or CC cord-345222-otfnrarh 154 17 decrease decrease VB cord-345222-otfnrarh 154 18 susceptibility susceptibility NN cord-345222-otfnrarh 154 19 to to IN cord-345222-otfnrarh 154 20 enteric enteric JJ cord-345222-otfnrarh 154 21 pathogens pathogen NNS cord-345222-otfnrarh 154 22 . . . cord-345222-otfnrarh 155 1 Depending depend VBG cord-345222-otfnrarh 155 2 on on IN cord-345222-otfnrarh 155 3 the the DT cord-345222-otfnrarh 155 4 age age NN cord-345222-otfnrarh 155 5 at at IN cord-345222-otfnrarh 155 6 acquisition acquisition NN cord-345222-otfnrarh 155 7 and and CC cord-345222-otfnrarh 155 8 the the DT cord-345222-otfnrarh 155 9 anatomical anatomical JJ cord-345222-otfnrarh 155 10 site site NN cord-345222-otfnrarh 155 11 of of IN cord-345222-otfnrarh 155 12 colonization colonization NN cord-345222-otfnrarh 155 13 , , , cord-345222-otfnrarh 155 14 for for IN cord-345222-otfnrarh 155 15 example example NN cord-345222-otfnrarh 155 16 , , , cord-345222-otfnrarh 155 17 H. H. NNP cord-345222-otfnrarh 155 18 pylori pylori NN cord-345222-otfnrarh 155 19 decreases decrease VBZ cord-345222-otfnrarh 155 20 gastric gastric JJ cord-345222-otfnrarh 155 21 acid acid NN cord-345222-otfnrarh 155 22 secretion secretion NN cord-345222-otfnrarh 155 23 in in IN cord-345222-otfnrarh 155 24 some some DT cord-345222-otfnrarh 155 25 people people NNS cord-345222-otfnrarh 155 26 , , , cord-345222-otfnrarh 155 27 thereby thereby RB cord-345222-otfnrarh 155 28 potentially potentially RB cord-345222-otfnrarh 155 29 reducing reduce VBG cord-345222-otfnrarh 155 30 the the DT cord-345222-otfnrarh 155 31 effectiveness effectiveness NN cord-345222-otfnrarh 155 32 of of IN cord-345222-otfnrarh 155 33 the the DT cord-345222-otfnrarh 155 34 gastric gastric JJ cord-345222-otfnrarh 155 35 acid acid NN cord-345222-otfnrarh 155 36 barrier barrier NN cord-345222-otfnrarh 155 37 to to IN cord-345222-otfnrarh 155 38 intestinal intestinal JJ cord-345222-otfnrarh 155 39 pathogens pathogen NNS cord-345222-otfnrarh 155 40 , , , cord-345222-otfnrarh 155 41 but but CC cord-345222-otfnrarh 155 42 increases increase VBZ cord-345222-otfnrarh 155 43 gastric gastric JJ cord-345222-otfnrarh 155 44 acid acid NN cord-345222-otfnrarh 155 45 secretion secretion NN cord-345222-otfnrarh 155 46 in in IN cord-345222-otfnrarh 155 47 others other NNS cord-345222-otfnrarh 155 48 . . . cord-345222-otfnrarh 156 1 51 51 CD cord-345222-otfnrarh 157 1 In in IN cord-345222-otfnrarh 157 2 this this DT cord-345222-otfnrarh 157 3 prospective prospective JJ cord-345222-otfnrarh 157 4 study study NN cord-345222-otfnrarh 157 5 , , , cord-345222-otfnrarh 157 6 H. H. NNP cord-345222-otfnrarh 157 7 pylori pylori NN cord-345222-otfnrarh 157 8 did do VBD cord-345222-otfnrarh 157 9 not not RB cord-345222-otfnrarh 157 10 seem seem VB cord-345222-otfnrarh 157 11 to to TO cord-345222-otfnrarh 157 12 increase increase VB cord-345222-otfnrarh 157 13 the the DT cord-345222-otfnrarh 157 14 risk risk NN cord-345222-otfnrarh 157 15 of of IN cord-345222-otfnrarh 157 16 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 157 17 in in IN cord-345222-otfnrarh 157 18 people people NNS cord-345222-otfnrarh 157 19 more more JJR cord-345222-otfnrarh 157 20 than than IN cord-345222-otfnrarh 157 21 2 2 CD cord-345222-otfnrarh 157 22 years year NNS cord-345222-otfnrarh 157 23 old old JJ cord-345222-otfnrarh 157 24 . . . cord-345222-otfnrarh 158 1 43 43 CD cord-345222-otfnrarh 159 1 These these DT cord-345222-otfnrarh 159 2 data datum NNS cord-345222-otfnrarh 159 3 have have VBP cord-345222-otfnrarh 159 4 recently recently RB cord-345222-otfnrarh 159 5 been be VBN cord-345222-otfnrarh 159 6 confirmed confirm VBN cord-345222-otfnrarh 159 7 . . . cord-345222-otfnrarh 160 1 52 52 CD cord-345222-otfnrarh 160 2 Klebsiella Klebsiella NNP cord-345222-otfnrarh 160 3 , , , cord-345222-otfnrarh 160 4 Enterobacter Enterobacter NNP cord-345222-otfnrarh 160 5 , , , cord-345222-otfnrarh 160 6 Citrobacter Citrobacter NNP cord-345222-otfnrarh 160 7 , , , cord-345222-otfnrarh 160 8 and and CC cord-345222-otfnrarh 160 9 Streptococcus Streptococcus NNP cord-345222-otfnrarh 160 10 group group NN cord-345222-otfnrarh 160 11 D d NN cord-345222-otfnrarh 160 12 have have VBP cord-345222-otfnrarh 160 13 been be VBN cord-345222-otfnrarh 160 14 isolated isolate VBN cord-345222-otfnrarh 160 15 from from IN cord-345222-otfnrarh 160 16 feces fece NNS cord-345222-otfnrarh 160 17 of of IN cord-345222-otfnrarh 160 18 sick sick JJ cord-345222-otfnrarh 160 19 newborns newborn NNS cord-345222-otfnrarh 160 20 and and CC cord-345222-otfnrarh 160 21 associated associate VBN cord-345222-otfnrarh 160 22 with with IN cord-345222-otfnrarh 160 23 intestinal intestinal JJ cord-345222-otfnrarh 160 24 disease disease NN cord-345222-otfnrarh 160 25 , , , cord-345222-otfnrarh 160 26 but but CC cord-345222-otfnrarh 160 27 there there EX cord-345222-otfnrarh 160 28 is be VBZ cord-345222-otfnrarh 160 29 insufficient insufficient JJ cord-345222-otfnrarh 160 30 evidence evidence NN cord-345222-otfnrarh 160 31 to to TO cord-345222-otfnrarh 160 32 define define VB cord-345222-otfnrarh 160 33 the the DT cord-345222-otfnrarh 160 34 pathogenic pathogenic JJ cord-345222-otfnrarh 160 35 role role NN cord-345222-otfnrarh 160 36 of of IN cord-345222-otfnrarh 160 37 these these DT cord-345222-otfnrarh 160 38 agents agent NNS cord-345222-otfnrarh 160 39 . . . cord-345222-otfnrarh 161 1 Proteus Proteus NNP cord-345222-otfnrarh 161 2 and and CC cord-345222-otfnrarh 161 3 Providencia Providencia NNP cord-345222-otfnrarh 161 4 , , , cord-345222-otfnrarh 161 5 although although IN cord-345222-otfnrarh 161 6 rarely rarely RB cord-345222-otfnrarh 161 7 , , , cord-345222-otfnrarh 161 8 may may MD cord-345222-otfnrarh 161 9 be be VB cord-345222-otfnrarh 161 10 responsible responsible JJ cord-345222-otfnrarh 161 11 for for IN cord-345222-otfnrarh 161 12 intestinal intestinal JJ cord-345222-otfnrarh 161 13 infections infection NNS cord-345222-otfnrarh 161 14 in in IN cord-345222-otfnrarh 161 15 newborns newborn NNS cord-345222-otfnrarh 161 16 . . . cord-345222-otfnrarh 162 1 Providencia Providencia NNP cord-345222-otfnrarh 162 2 species specie NNS cord-345222-otfnrarh 162 3 occur occur VBP cord-345222-otfnrarh 162 4 in in IN cord-345222-otfnrarh 162 5 normal normal JJ cord-345222-otfnrarh 162 6 feces fece NNS cord-345222-otfnrarh 162 7 and and CC cord-345222-otfnrarh 162 8 have have VBP cord-345222-otfnrarh 162 9 been be VBN cord-345222-otfnrarh 162 10 isolated isolate VBN cord-345222-otfnrarh 162 11 from from IN cord-345222-otfnrarh 162 12 epidemic epidemic NN cord-345222-otfnrarh 162 13 and and CC cord-345222-otfnrarh 162 14 sporadic sporadic JJ cord-345222-otfnrarh 162 15 causes cause NNS cord-345222-otfnrarh 162 16 of of IN cord-345222-otfnrarh 162 17 diarrhea diarrhea NN cord-345222-otfnrarh 162 18 , , , cord-345222-otfnrarh 162 19 though though IN cord-345222-otfnrarh 162 20 their -PRON- PRP$ cord-345222-otfnrarh 162 21 importance importance NN cord-345222-otfnrarh 162 22 in in IN cord-345222-otfnrarh 162 23 the the DT cord-345222-otfnrarh 162 24 causation causation NN cord-345222-otfnrarh 162 25 of of IN cord-345222-otfnrarh 162 26 diarrheal diarrheal JJ cord-345222-otfnrarh 162 27 disease disease NN cord-345222-otfnrarh 162 28 is be VBZ cord-345222-otfnrarh 162 29 not not RB cord-345222-otfnrarh 162 30 easy easy JJ cord-345222-otfnrarh 162 31 to to TO cord-345222-otfnrarh 162 32 assess assess VB cord-345222-otfnrarh 162 33 . . . cord-345222-otfnrarh 163 1 53 53 CD cord-345222-otfnrarh 164 1 Pseudomonas Pseudomonas NNP cord-345222-otfnrarh 164 2 aeruginosa aeruginosa NN cord-345222-otfnrarh 164 3 can can MD cord-345222-otfnrarh 164 4 colonize colonize VB cord-345222-otfnrarh 164 5 ( ( -LRB- cord-345222-otfnrarh 164 6 0%-10 0%-10 CD cord-345222-otfnrarh 164 7 % % NN cord-345222-otfnrarh 164 8 ) ) -RRB- cord-345222-otfnrarh 165 1 the the DT cord-345222-otfnrarh 165 2 intestine intestine NN cord-345222-otfnrarh 165 3 of of IN cord-345222-otfnrarh 165 4 the the DT cord-345222-otfnrarh 165 5 newborn newborn NN cord-345222-otfnrarh 165 6 during during IN cord-345222-otfnrarh 165 7 the the DT cord-345222-otfnrarh 165 8 first first JJ cord-345222-otfnrarh 165 9 days day NNS cord-345222-otfnrarh 165 10 of of IN cord-345222-otfnrarh 165 11 life life NN cord-345222-otfnrarh 165 12 . . . cord-345222-otfnrarh 166 1 54 54 CD cord-345222-otfnrarh 167 1 Clinically clinically RB cord-345222-otfnrarh 167 2 , , , cord-345222-otfnrarh 167 3 the the DT cord-345222-otfnrarh 167 4 infection infection NN cord-345222-otfnrarh 167 5 may may MD cord-345222-otfnrarh 167 6 be be VB cord-345222-otfnrarh 167 7 asymptomatic asymptomatic JJ cord-345222-otfnrarh 167 8 at at IN cord-345222-otfnrarh 167 9 first first RB cord-345222-otfnrarh 167 10 , , , cord-345222-otfnrarh 167 11 later later RB cord-345222-otfnrarh 167 12 developing develop VBG cord-345222-otfnrarh 167 13 into into IN cord-345222-otfnrarh 167 14 grayish grayish JJ cord-345222-otfnrarh 167 15 - - HYPH cord-345222-otfnrarh 167 16 blue blue JJ cord-345222-otfnrarh 167 17 stool stool NN cord-345222-otfnrarh 167 18 color color NN cord-345222-otfnrarh 167 19 or or CC cord-345222-otfnrarh 167 20 watery watery JJ cord-345222-otfnrarh 167 21 diarrhea diarrhea NN cord-345222-otfnrarh 167 22 , , , cord-345222-otfnrarh 167 23 profuse profuse JJ cord-345222-otfnrarh 167 24 vomiting vomiting NN cord-345222-otfnrarh 167 25 , , , cord-345222-otfnrarh 167 26 and and CC cord-345222-otfnrarh 167 27 systemic systemic JJ cord-345222-otfnrarh 167 28 symptoms symptom NNS cord-345222-otfnrarh 167 29 . . . cord-345222-otfnrarh 168 1 Salmonella salmonella NN cord-345222-otfnrarh 168 2 pass pass VB cord-345222-otfnrarh 168 3 through through IN cord-345222-otfnrarh 168 4 the the DT cord-345222-otfnrarh 168 5 intestinal intestinal JJ cord-345222-otfnrarh 168 6 mucosa mucosa NN cord-345222-otfnrarh 168 7 and and CC cord-345222-otfnrarh 168 8 multiply multiply VB cord-345222-otfnrarh 168 9 within within IN cord-345222-otfnrarh 168 10 the the DT cord-345222-otfnrarh 168 11 lamina lamina JJ cord-345222-otfnrarh 168 12 propria propria NN cord-345222-otfnrarh 168 13 , , , cord-345222-otfnrarh 168 14 may may MD cord-345222-otfnrarh 168 15 invade invade VB cord-345222-otfnrarh 168 16 mesenteric mesenteric JJ cord-345222-otfnrarh 168 17 lymphonodes lymphonode NNS cord-345222-otfnrarh 168 18 , , , cord-345222-otfnrarh 168 19 and and CC cord-345222-otfnrarh 168 20 systemic systemic JJ cord-345222-otfnrarh 168 21 spread spread NN cord-345222-otfnrarh 168 22 of of IN cord-345222-otfnrarh 168 23 the the DT cord-345222-otfnrarh 168 24 organisms organism NNS cord-345222-otfnrarh 168 25 can can MD cord-345222-otfnrarh 168 26 occur occur VB cord-345222-otfnrarh 168 27 , , , cord-345222-otfnrarh 168 28 giving give VBG cord-345222-otfnrarh 168 29 rise rise NN cord-345222-otfnrarh 168 30 to to IN cord-345222-otfnrarh 168 31 enteric enteric JJ cord-345222-otfnrarh 168 32 fever fever NN cord-345222-otfnrarh 168 33 . . . cord-345222-otfnrarh 169 1 55 55 CD cord-345222-otfnrarh 170 1 In in IN cord-345222-otfnrarh 170 2 fact fact NN cord-345222-otfnrarh 170 3 , , , cord-345222-otfnrarh 170 4 3%-5 3%-5 CD cord-345222-otfnrarh 170 5 % % NN cord-345222-otfnrarh 170 6 of of IN cord-345222-otfnrarh 170 7 infants infant NNS cord-345222-otfnrarh 170 8 may may MD cord-345222-otfnrarh 170 9 have have VB cord-345222-otfnrarh 170 10 extraintestinal extraintestinal JJ cord-345222-otfnrarh 170 11 symptoms symptom NNS cord-345222-otfnrarh 170 12 . . . cord-345222-otfnrarh 171 1 The the DT cord-345222-otfnrarh 171 2 colonization colonization NN cord-345222-otfnrarh 171 3 and and CC cord-345222-otfnrarh 171 4 initial initial JJ cord-345222-otfnrarh 171 5 invasion invasion NN cord-345222-otfnrarh 171 6 probably probably RB cord-345222-otfnrarh 171 7 occur occur VBP cord-345222-otfnrarh 171 8 at at IN cord-345222-otfnrarh 171 9 the the DT cord-345222-otfnrarh 171 10 distal distal JJ cord-345222-otfnrarh 171 11 ileum ileum NN cord-345222-otfnrarh 171 12 , , , cord-345222-otfnrarh 171 13 while while IN cord-345222-otfnrarh 171 14 the the DT cord-345222-otfnrarh 171 15 mucosal mucosal JJ cord-345222-otfnrarh 171 16 edema edema NN cord-345222-otfnrarh 171 17 and and CC cord-345222-otfnrarh 171 18 cryptic cryptic JJ cord-345222-otfnrarh 171 19 abscesses abscess NNS cord-345222-otfnrarh 171 20 are be VBP cord-345222-otfnrarh 171 21 frequently frequently RB cord-345222-otfnrarh 171 22 in in IN cord-345222-otfnrarh 171 23 the the DT cord-345222-otfnrarh 171 24 colon colon NN cord-345222-otfnrarh 171 25 . . . cord-345222-otfnrarh 172 1 The the DT cord-345222-otfnrarh 172 2 diarrhea diarrhea NN cord-345222-otfnrarh 172 3 is be VBZ cord-345222-otfnrarh 172 4 due due JJ cord-345222-otfnrarh 172 5 to to IN cord-345222-otfnrarh 172 6 secretion secretion NN cord-345222-otfnrarh 172 7 of of IN cord-345222-otfnrarh 172 8 fluid fluid NN cord-345222-otfnrarh 172 9 and and CC cord-345222-otfnrarh 172 10 electrolytes electrolyte NNS cord-345222-otfnrarh 172 11 by by IN cord-345222-otfnrarh 172 12 the the DT cord-345222-otfnrarh 172 13 small small JJ cord-345222-otfnrarh 172 14 and and CC cord-345222-otfnrarh 172 15 large large JJ cord-345222-otfnrarh 172 16 intestines intestine NNS cord-345222-otfnrarh 172 17 . . . cord-345222-otfnrarh 173 1 The the DT cord-345222-otfnrarh 173 2 incubation incubation NN cord-345222-otfnrarh 173 3 period period NN cord-345222-otfnrarh 173 4 is be VBZ cord-345222-otfnrarh 173 5 usually usually RB cord-345222-otfnrarh 173 6 12 12 CD cord-345222-otfnrarh 173 7 - - SYM cord-345222-otfnrarh 173 8 48 48 CD cord-345222-otfnrarh 173 9 hours hour NNS cord-345222-otfnrarh 173 10 , , , cord-345222-otfnrarh 173 11 rarely rarely RB cord-345222-otfnrarh 173 12 for for IN cord-345222-otfnrarh 173 13 a a DT cord-345222-otfnrarh 173 14 few few JJ cord-345222-otfnrarh 173 15 days day NNS cord-345222-otfnrarh 173 16 . . . cord-345222-otfnrarh 174 1 22 22 CD cord-345222-otfnrarh 174 2 _SP cord-345222-otfnrarh 175 1 Salmonella salmonella NN cord-345222-otfnrarh 175 2 spp spp NN cord-345222-otfnrarh 175 3 is be VBZ cord-345222-otfnrarh 175 4 normally normally RB cord-345222-otfnrarh 175 5 acquired acquire VBN cord-345222-otfnrarh 175 6 through through IN cord-345222-otfnrarh 175 7 the the DT cord-345222-otfnrarh 175 8 birth birth NN cord-345222-otfnrarh 175 9 canal canal NN cord-345222-otfnrarh 175 10 , , , cord-345222-otfnrarh 175 11 and and CC cord-345222-otfnrarh 175 12 the the DT cord-345222-otfnrarh 175 13 mother mother NN cord-345222-otfnrarh 175 14 can can MD cord-345222-otfnrarh 175 15 be be VB cord-345222-otfnrarh 175 16 an an DT cord-345222-otfnrarh 175 17 asymptomatic asymptomatic JJ cord-345222-otfnrarh 175 18 carrier carrier NN cord-345222-otfnrarh 175 19 . . . cord-345222-otfnrarh 176 1 55 55 CD cord-345222-otfnrarh 176 2 Shigella Shigella NNP cord-345222-otfnrarh 176 3 spp spp NNS cord-345222-otfnrarh 176 4 are be VBP cord-345222-otfnrarh 176 5 the the DT cord-345222-otfnrarh 176 6 leading lead VBG cord-345222-otfnrarh 176 7 bacterial bacterial JJ cord-345222-otfnrarh 176 8 causes cause NNS cord-345222-otfnrarh 176 9 of of IN cord-345222-otfnrarh 176 10 diarrhea diarrhea NN cord-345222-otfnrarh 176 11 worldwide worldwide RB cord-345222-otfnrarh 176 12 and and CC cord-345222-otfnrarh 176 13 are be VBP cord-345222-otfnrarh 176 14 relatively relatively RB cord-345222-otfnrarh 176 15 common common JJ cord-345222-otfnrarh 176 16 in in IN cord-345222-otfnrarh 176 17 children child NNS cord-345222-otfnrarh 176 18 . . . cord-345222-otfnrarh 177 1 They -PRON- PRP cord-345222-otfnrarh 177 2 cause cause VBP cord-345222-otfnrarh 177 3 invasive invasive JJ cord-345222-otfnrarh 177 4 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 177 5 , , , cord-345222-otfnrarh 177 6 and and CC cord-345222-otfnrarh 177 7 symptoms symptom NNS cord-345222-otfnrarh 177 8 can can MD cord-345222-otfnrarh 177 9 take take VB cord-345222-otfnrarh 177 10 as as RB cord-345222-otfnrarh 177 11 long long RB cord-345222-otfnrarh 177 12 as as IN cord-345222-otfnrarh 177 13 a a DT cord-345222-otfnrarh 177 14 week week NN cord-345222-otfnrarh 177 15 to to TO cord-345222-otfnrarh 177 16 show show VB cord-345222-otfnrarh 177 17 up up RP cord-345222-otfnrarh 177 18 , , , cord-345222-otfnrarh 177 19 but but CC cord-345222-otfnrarh 177 20 most most RBS cord-345222-otfnrarh 177 21 often often RB cord-345222-otfnrarh 177 22 begin begin VBP cord-345222-otfnrarh 177 23 2 2 CD cord-345222-otfnrarh 177 24 - - SYM cord-345222-otfnrarh 177 25 4 4 CD cord-345222-otfnrarh 177 26 days day NNS cord-345222-otfnrarh 177 27 after after IN cord-345222-otfnrarh 177 28 ingestion ingestion NN cord-345222-otfnrarh 177 29 . . . cord-345222-otfnrarh 178 1 Mild mild JJ cord-345222-otfnrarh 178 2 symptoms symptom NNS cord-345222-otfnrarh 178 3 are be VBP cord-345222-otfnrarh 178 4 self self NN cord-345222-otfnrarh 178 5 - - HYPH cord-345222-otfnrarh 178 6 limiting limit VBG cord-345222-otfnrarh 178 7 , , , cord-345222-otfnrarh 178 8 but but CC cord-345222-otfnrarh 178 9 S. S. NNP cord-345222-otfnrarh 178 10 dysenteriae dysenteriae NN cord-345222-otfnrarh 178 11 serotype serotype NN cord-345222-otfnrarh 178 12 1 1 CD cord-345222-otfnrarh 178 13 resistance resistance NN cord-345222-otfnrarh 178 14 to to IN cord-345222-otfnrarh 178 15 multiple multiple JJ cord-345222-otfnrarh 178 16 antibiotics antibiotic NNS cord-345222-otfnrarh 178 17 has have VBZ cord-345222-otfnrarh 178 18 the the DT cord-345222-otfnrarh 178 19 ability ability NN cord-345222-otfnrarh 178 20 to to TO cord-345222-otfnrarh 178 21 elaborate elaborate VB cord-345222-otfnrarh 178 22 the the DT cord-345222-otfnrarh 178 23 potent potent JJ cord-345222-otfnrarh 178 24 Shiga Shiga NNP cord-345222-otfnrarh 178 25 toxin toxin NN cord-345222-otfnrarh 178 26 , , , cord-345222-otfnrarh 178 27 which which WDT cord-345222-otfnrarh 178 28 may may MD cord-345222-otfnrarh 178 29 lead lead VB cord-345222-otfnrarh 178 30 to to IN cord-345222-otfnrarh 178 31 extraintestinal extraintestinal JJ cord-345222-otfnrarh 178 32 complications complication NNS cord-345222-otfnrarh 178 33 , , , cord-345222-otfnrarh 178 34 including include VBG cord-345222-otfnrarh 178 35 HUS hus NN cord-345222-otfnrarh 178 36 and and CC cord-345222-otfnrarh 178 37 death death NN cord-345222-otfnrarh 178 38 . . . cord-345222-otfnrarh 179 1 56 56 CD cord-345222-otfnrarh 179 2 Cases case NNS cord-345222-otfnrarh 179 3 of of IN cord-345222-otfnrarh 179 4 neonatal neonatal JJ cord-345222-otfnrarh 179 5 infections infection NNS cord-345222-otfnrarh 179 6 from from IN cord-345222-otfnrarh 179 7 Staphylococcus Staphylococcus NNP cord-345222-otfnrarh 179 8 aureus aureu NNS cord-345222-otfnrarh 179 9 are be VBP cord-345222-otfnrarh 179 10 reported report VBN cord-345222-otfnrarh 179 11 in in IN cord-345222-otfnrarh 179 12 the the DT cord-345222-otfnrarh 179 13 literature literature NN cord-345222-otfnrarh 179 14 . . . cord-345222-otfnrarh 180 1 The the DT cord-345222-otfnrarh 180 2 pathogen pathogen NN cord-345222-otfnrarh 180 3 produces produce VBZ cord-345222-otfnrarh 180 4 two two CD cord-345222-otfnrarh 180 5 enterotoxins enterotoxin NNS cord-345222-otfnrarh 180 6 , , , cord-345222-otfnrarh 180 7 G G NNP cord-345222-otfnrarh 180 8 and and CC cord-345222-otfnrarh 180 9 I -PRON- PRP cord-345222-otfnrarh 180 10 , , , cord-345222-otfnrarh 180 11 that that WDT cord-345222-otfnrarh 180 12 cause cause VBP cord-345222-otfnrarh 180 13 atrophy atrophy NN cord-345222-otfnrarh 180 14 of of IN cord-345222-otfnrarh 180 15 intestinal intestinal JJ cord-345222-otfnrarh 180 16 villi villi NN cord-345222-otfnrarh 180 17 , , , cord-345222-otfnrarh 180 18 diarrhea diarrhea NN cord-345222-otfnrarh 180 19 , , , cord-345222-otfnrarh 180 20 and and CC cord-345222-otfnrarh 180 21 poor poor JJ cord-345222-otfnrarh 180 22 growth growth NN cord-345222-otfnrarh 180 23 during during IN cord-345222-otfnrarh 180 24 the the DT cord-345222-otfnrarh 180 25 first first JJ cord-345222-otfnrarh 180 26 weeks week NNS cord-345222-otfnrarh 180 27 of of IN cord-345222-otfnrarh 180 28 life life NN cord-345222-otfnrarh 180 29 . . . cord-345222-otfnrarh 181 1 Vibrio Vibrio NNP cord-345222-otfnrarh 181 2 cholerae cholerae NN cord-345222-otfnrarh 181 3 causes cause VBZ cord-345222-otfnrarh 181 4 watery watery JJ cord-345222-otfnrarh 181 5 diarrhea diarrhea NN cord-345222-otfnrarh 181 6 through through IN cord-345222-otfnrarh 181 7 the the DT cord-345222-otfnrarh 181 8 production production NN cord-345222-otfnrarh 181 9 of of IN cord-345222-otfnrarh 181 10 cholera cholera NN cord-345222-otfnrarh 181 11 toxin toxin NN cord-345222-otfnrarh 181 12 without without IN cord-345222-otfnrarh 181 13 invading invade VBG cord-345222-otfnrarh 181 14 the the DT cord-345222-otfnrarh 181 15 intestinal intestinal JJ cord-345222-otfnrarh 181 16 mucosa mucosa NN cord-345222-otfnrarh 181 17 . . . cord-345222-otfnrarh 182 1 Yersinia Yersinia NNP cord-345222-otfnrarh 182 2 enterocolitica enterocolitica NNP cord-345222-otfnrarh 182 3 is be VBZ cord-345222-otfnrarh 182 4 a a DT cord-345222-otfnrarh 182 5 common common JJ cord-345222-otfnrarh 182 6 enteropathogen enteropathogen NN cord-345222-otfnrarh 182 7 usually usually RB cord-345222-otfnrarh 182 8 causing cause VBG cord-345222-otfnrarh 182 9 relatively relatively RB cord-345222-otfnrarh 182 10 mild mild JJ cord-345222-otfnrarh 182 11 disease disease NN cord-345222-otfnrarh 182 12 . . . cord-345222-otfnrarh 183 1 Y. Y. NNP cord-345222-otfnrarh 183 2 enterocolitica enterocolitica NNP cord-345222-otfnrarh 183 3 crosses cross VBZ cord-345222-otfnrarh 183 4 the the DT cord-345222-otfnrarh 183 5 intestinal intestinal JJ cord-345222-otfnrarh 183 6 mucosa mucosa NN cord-345222-otfnrarh 183 7 , , , cord-345222-otfnrarh 183 8 replicates replicate VBZ cord-345222-otfnrarh 183 9 in in IN cord-345222-otfnrarh 183 10 Peyer Peyer NNP cord-345222-otfnrarh 183 11 's 's POS cord-345222-otfnrarh 183 12 patches patch NNS cord-345222-otfnrarh 183 13 , , , cord-345222-otfnrarh 183 14 and and CC cord-345222-otfnrarh 183 15 children child NNS cord-345222-otfnrarh 183 16 infected infect VBD cord-345222-otfnrarh 183 17 present present JJ cord-345222-otfnrarh 183 18 acute acute JJ cord-345222-otfnrarh 183 19 diarrhea diarrhea NN cord-345222-otfnrarh 183 20 associated associate VBN cord-345222-otfnrarh 183 21 with with IN cord-345222-otfnrarh 183 22 fever fever NN cord-345222-otfnrarh 183 23 and and CC cord-345222-otfnrarh 183 24 pharyngitis pharyngitis NN cord-345222-otfnrarh 183 25 , , , cord-345222-otfnrarh 183 26 chronic chronic JJ cord-345222-otfnrarh 183 27 or or CC cord-345222-otfnrarh 183 28 recurrent recurrent JJ cord-345222-otfnrarh 183 29 diarrhea diarrhea NN cord-345222-otfnrarh 183 30 , , , cord-345222-otfnrarh 183 31 or or CC cord-345222-otfnrarh 183 32 abdominal abdominal JJ cord-345222-otfnrarh 183 33 pain pain NN cord-345222-otfnrarh 183 34 associated associate VBN cord-345222-otfnrarh 183 35 with with IN cord-345222-otfnrarh 183 36 mesenteric mesenteric JJ cord-345222-otfnrarh 183 37 adenitis adenitis NN cord-345222-otfnrarh 183 38 . . . cord-345222-otfnrarh 184 1 This this DT cord-345222-otfnrarh 184 2 infection infection NN cord-345222-otfnrarh 184 3 looks look VBZ cord-345222-otfnrarh 184 4 like like IN cord-345222-otfnrarh 184 5 Salmonella salmonella NN cord-345222-otfnrarh 184 6 infections infection NNS cord-345222-otfnrarh 184 7 , , , cord-345222-otfnrarh 184 8 with with IN cord-345222-otfnrarh 184 9 feces fece NNS cord-345222-otfnrarh 184 10 containing contain VBG cord-345222-otfnrarh 184 11 mucus mucus NN cord-345222-otfnrarh 184 12 with with IN cord-345222-otfnrarh 184 13 or or CC cord-345222-otfnrarh 184 14 without without IN cord-345222-otfnrarh 184 15 blood blood NN cord-345222-otfnrarh 184 16 . . . cord-345222-otfnrarh 185 1 The the DT cord-345222-otfnrarh 185 2 pathogen pathogen NN cord-345222-otfnrarh 185 3 , , , cord-345222-otfnrarh 185 4 within within IN cord-345222-otfnrarh 185 5 phagocytes phagocyte NNS cord-345222-otfnrarh 185 6 , , , cord-345222-otfnrarh 185 7 can can MD cord-345222-otfnrarh 185 8 reach reach VB cord-345222-otfnrarh 185 9 other other JJ cord-345222-otfnrarh 185 10 sites site NNS cord-345222-otfnrarh 185 11 through through IN cord-345222-otfnrarh 185 12 the the DT cord-345222-otfnrarh 185 13 bloodstream bloodstream NN cord-345222-otfnrarh 185 14 . . . cord-345222-otfnrarh 186 1 Some some DT cord-345222-otfnrarh 186 2 of of IN cord-345222-otfnrarh 186 3 the the DT cord-345222-otfnrarh 186 4 Y. Y. NNP cord-345222-otfnrarh 186 5 enterocolitica enterocolitica NNP cord-345222-otfnrarh 186 6 pathogenic pathogenic NNP cord-345222-otfnrarh 186 7 biotypes biotypes NNP cord-345222-otfnrarh 186 8 express express VBP cord-345222-otfnrarh 186 9 the the DT cord-345222-otfnrarh 186 10 yst yst NNP cord-345222-otfnrarh 186 11 gene gene NN cord-345222-otfnrarh 186 12 encoding encoding NN cord-345222-otfnrarh 186 13 for for IN cord-345222-otfnrarh 186 14 an an DT cord-345222-otfnrarh 186 15 heat heat NN cord-345222-otfnrarh 186 16 - - HYPH cord-345222-otfnrarh 186 17 stable stable JJ cord-345222-otfnrarh 186 18 enterotoxin enterotoxin NN cord-345222-otfnrarh 186 19 that that WDT cord-345222-otfnrarh 186 20 may may MD cord-345222-otfnrarh 186 21 contribute contribute VB cord-345222-otfnrarh 186 22 to to IN cord-345222-otfnrarh 186 23 the the DT cord-345222-otfnrarh 186 24 pathogenesis pathogenesis NN cord-345222-otfnrarh 186 25 of of IN cord-345222-otfnrarh 186 26 diarrhea diarrhea NN cord-345222-otfnrarh 186 27 . . . cord-345222-otfnrarh 187 1 57 57 CD cord-345222-otfnrarh 187 2 , , , cord-345222-otfnrarh 187 3 58 58 CD cord-345222-otfnrarh 187 4 viral viral JJ cord-345222-otfnrarh 187 5 enteritis enteritis NN cord-345222-otfnrarh 187 6 ( ( -LRB- cord-345222-otfnrarh 187 7 Table table NN cord-345222-otfnrarh 187 8 1B 1b CD cord-345222-otfnrarh 187 9 ) ) -RRB- cord-345222-otfnrarh 188 1 Viruses virus NNS cord-345222-otfnrarh 188 2 are be VBP cord-345222-otfnrarh 188 3 responsible responsible JJ cord-345222-otfnrarh 188 4 for for IN cord-345222-otfnrarh 188 5 approximately approximately RB cord-345222-otfnrarh 188 6 70 70 CD cord-345222-otfnrarh 188 7 % % NN cord-345222-otfnrarh 188 8 of of IN cord-345222-otfnrarh 188 9 the the DT cord-345222-otfnrarh 188 10 episodes episode NNS cord-345222-otfnrarh 188 11 of of IN cord-345222-otfnrarh 188 12 acute acute JJ cord-345222-otfnrarh 188 13 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 188 14 in in IN cord-345222-otfnrarh 188 15 children child NNS cord-345222-otfnrarh 188 16 . . . cord-345222-otfnrarh 189 1 Viral viral JJ cord-345222-otfnrarh 189 2 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 189 3 is be VBZ cord-345222-otfnrarh 189 4 of of IN cord-345222-otfnrarh 189 5 shorter short JJR cord-345222-otfnrarh 189 6 duration duration NN cord-345222-otfnrarh 189 7 than than IN cord-345222-otfnrarh 189 8 bacterial bacterial JJ cord-345222-otfnrarh 189 9 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 189 10 and and CC cord-345222-otfnrarh 189 11 associated associate VBN cord-345222-otfnrarh 189 12 with with IN cord-345222-otfnrarh 189 13 an an DT cord-345222-otfnrarh 189 14 increased increase VBN cord-345222-otfnrarh 189 15 risk risk NN cord-345222-otfnrarh 189 16 of of IN cord-345222-otfnrarh 189 17 vomiting vomiting NN cord-345222-otfnrarh 189 18 and and CC cord-345222-otfnrarh 189 19 dehydration dehydration NN cord-345222-otfnrarh 189 20 compared compare VBN cord-345222-otfnrarh 189 21 with with IN cord-345222-otfnrarh 189 22 those those DT cord-345222-otfnrarh 189 23 without without IN cord-345222-otfnrarh 189 24 viral viral JJ cord-345222-otfnrarh 189 25 infection infection NN cord-345222-otfnrarh 189 26 . . . cord-345222-otfnrarh 190 1 The the DT cord-345222-otfnrarh 190 2 severity severity NN cord-345222-otfnrarh 190 3 of of IN cord-345222-otfnrarh 190 4 dehydration dehydration NN cord-345222-otfnrarh 190 5 is be VBZ cord-345222-otfnrarh 190 6 significantly significantly RB cord-345222-otfnrarh 190 7 higher high JJR cord-345222-otfnrarh 190 8 in in IN cord-345222-otfnrarh 190 9 children child NNS cord-345222-otfnrarh 190 10 infected infect VBN cord-345222-otfnrarh 190 11 with with IN cord-345222-otfnrarh 190 12 either either DT cord-345222-otfnrarh 190 13 astrovirus astrovirus NNP cord-345222-otfnrarh 190 14 or or CC cord-345222-otfnrarh 190 15 rotavirus rotavirus JJ cord-345222-otfnrarh 190 16 group group NN cord-345222-otfnrarh 191 1 A. A. NNP cord-345222-otfnrarh 191 2 Prolonged prolonged JJ cord-345222-otfnrarh 191 3 hospitalization hospitalization NN cord-345222-otfnrarh 191 4 is be VBZ cord-345222-otfnrarh 191 5 also also RB cord-345222-otfnrarh 191 6 more more RBR cord-345222-otfnrarh 191 7 likely likely JJ cord-345222-otfnrarh 191 8 to to TO cord-345222-otfnrarh 191 9 occur occur VB cord-345222-otfnrarh 191 10 with with IN cord-345222-otfnrarh 191 11 rotavirus rotavirus JJ cord-345222-otfnrarh 191 12 infection infection NN cord-345222-otfnrarh 191 13 . . . cord-345222-otfnrarh 192 1 4 4 LS cord-345222-otfnrarh 192 2 , , , cord-345222-otfnrarh 192 3 22 22 CD cord-345222-otfnrarh 192 4 , , , cord-345222-otfnrarh 192 5 55 55 CD cord-345222-otfnrarh 192 6 , , , cord-345222-otfnrarh 192 7 59 59 CD cord-345222-otfnrarh 192 8 , , , cord-345222-otfnrarh 192 9 60 60 CD cord-345222-otfnrarh 192 10 Enteric enteric JJ cord-345222-otfnrarh 192 11 adenoviruses adenovirus NNS cord-345222-otfnrarh 192 12 are be VBP cord-345222-otfnrarh 192 13 a a DT cord-345222-otfnrarh 192 14 common common JJ cord-345222-otfnrarh 192 15 cause cause NN cord-345222-otfnrarh 192 16 of of IN cord-345222-otfnrarh 192 17 viral viral JJ cord-345222-otfnrarh 192 18 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 192 19 in in IN cord-345222-otfnrarh 192 20 infants infant NNS cord-345222-otfnrarh 192 21 and and CC cord-345222-otfnrarh 192 22 young young JJ cord-345222-otfnrarh 192 23 children child NNS cord-345222-otfnrarh 192 24 . . . cord-345222-otfnrarh 193 1 Although although IN cord-345222-otfnrarh 193 2 there there EX cord-345222-otfnrarh 193 3 are be VBP cord-345222-otfnrarh 193 4 many many JJ cord-345222-otfnrarh 193 5 serotypes serotype NNS cord-345222-otfnrarh 193 6 of of IN cord-345222-otfnrarh 193 7 adenovirus adenovirus NN cord-345222-otfnrarh 193 8 that that WDT cord-345222-otfnrarh 193 9 can can MD cord-345222-otfnrarh 193 10 be be VB cord-345222-otfnrarh 193 11 found find VBN cord-345222-otfnrarh 193 12 in in IN cord-345222-otfnrarh 193 13 the the DT cord-345222-otfnrarh 193 14 stool stool NN cord-345222-otfnrarh 193 15 especially especially RB cord-345222-otfnrarh 193 16 during during IN cord-345222-otfnrarh 193 17 and and CC cord-345222-otfnrarh 193 18 after after IN cord-345222-otfnrarh 193 19 typical typical JJ cord-345222-otfnrarh 193 20 infections infection NNS cord-345222-otfnrarh 193 21 of of IN cord-345222-otfnrarh 193 22 the the DT cord-345222-otfnrarh 193 23 upper upper JJ cord-345222-otfnrarh 193 24 respiratory respiratory JJ cord-345222-otfnrarh 193 25 tract tract NN cord-345222-otfnrarh 193 26 , , , cord-345222-otfnrarh 193 27 only only RB cord-345222-otfnrarh 193 28 serotypes serotype NNS cord-345222-otfnrarh 193 29 40 40 CD cord-345222-otfnrarh 193 30 and and CC cord-345222-otfnrarh 193 31 41 41 CD cord-345222-otfnrarh 193 32 cause cause NN cord-345222-otfnrarh 193 33 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 193 34 and and CC cord-345222-otfnrarh 193 35 are be VBP cord-345222-otfnrarh 193 36 very very RB cord-345222-otfnrarh 193 37 difficult difficult JJ cord-345222-otfnrarh 193 38 to to TO cord-345222-otfnrarh 193 39 grow grow VB cord-345222-otfnrarh 193 40 in in IN cord-345222-otfnrarh 193 41 tissue tissue NN cord-345222-otfnrarh 193 42 culture culture NN cord-345222-otfnrarh 193 43 . . . cord-345222-otfnrarh 194 1 61 61 CD cord-345222-otfnrarh 195 1 Adenovirus Adenovirus NNP cord-345222-otfnrarh 195 2 directly directly RB cord-345222-otfnrarh 195 3 infects infect VBZ cord-345222-otfnrarh 195 4 intestinal intestinal JJ cord-345222-otfnrarh 195 5 enterocytes enterocyte NNS cord-345222-otfnrarh 195 6 , , , cord-345222-otfnrarh 195 7 causing cause VBG cord-345222-otfnrarh 195 8 villous villous NNP cord-345222-otfnrarh 195 9 hypoplasia hypoplasia NN cord-345222-otfnrarh 195 10 and and CC cord-345222-otfnrarh 195 11 crypt crypt NN cord-345222-otfnrarh 195 12 hypertrophy hypertrophy NN cord-345222-otfnrarh 195 13 . . . cord-345222-otfnrarh 196 1 The the DT cord-345222-otfnrarh 196 2 virus virus NN cord-345222-otfnrarh 196 3 causes cause VBZ cord-345222-otfnrarh 196 4 a a DT cord-345222-otfnrarh 196 5 massive massive JJ cord-345222-otfnrarh 196 6 infiltration infiltration NN cord-345222-otfnrarh 196 7 of of IN cord-345222-otfnrarh 196 8 the the DT cord-345222-otfnrarh 196 9 lamina lamina JJ cord-345222-otfnrarh 196 10 propria propria NN cord-345222-otfnrarh 196 11 of of IN cord-345222-otfnrarh 196 12 the the DT cord-345222-otfnrarh 196 13 villi villi NN cord-345222-otfnrarh 196 14 by by IN cord-345222-otfnrarh 196 15 mononuclear mononuclear JJ cord-345222-otfnrarh 196 16 cells cell NNS cord-345222-otfnrarh 196 17 . . . cord-345222-otfnrarh 197 1 Enteric enteric JJ cord-345222-otfnrarh 197 2 adenovirus adenovirus NN cord-345222-otfnrarh 197 3 is be VBZ cord-345222-otfnrarh 197 4 associated associate VBN cord-345222-otfnrarh 197 5 with with IN cord-345222-otfnrarh 197 6 longer long RBR cord-345222-otfnrarh 197 7 lasting lasting JJ cord-345222-otfnrarh 197 8 diarrhoea diarrhoea NN cord-345222-otfnrarh 197 9 , , , cord-345222-otfnrarh 197 10 compared compare VBN cord-345222-otfnrarh 197 11 to to IN cord-345222-otfnrarh 197 12 other other JJ cord-345222-otfnrarh 197 13 viral viral JJ cord-345222-otfnrarh 197 14 gents gent NNS cord-345222-otfnrarh 197 15 . . . cord-345222-otfnrarh 198 1 4 4 LS cord-345222-otfnrarh 198 2 , , , cord-345222-otfnrarh 198 3 22 22 CD cord-345222-otfnrarh 198 4 , , , cord-345222-otfnrarh 198 5 55 55 CD cord-345222-otfnrarh 198 6 Maternal maternal JJ cord-345222-otfnrarh 198 7 antibodies antibody NNS cord-345222-otfnrarh 198 8 are be VBP cord-345222-otfnrarh 198 9 certainly certainly RB cord-345222-otfnrarh 198 10 protective protective JJ cord-345222-otfnrarh 198 11 ; ; : cord-345222-otfnrarh 198 12 however however RB cord-345222-otfnrarh 198 13 , , , cord-345222-otfnrarh 198 14 among among IN cord-345222-otfnrarh 198 15 premature premature JJ cord-345222-otfnrarh 198 16 and/or and/or CC cord-345222-otfnrarh 198 17 low low JJ cord-345222-otfnrarh 198 18 - - HYPH cord-345222-otfnrarh 198 19 birth birth NN cord-345222-otfnrarh 198 20 - - HYPH cord-345222-otfnrarh 198 21 weight weight NN cord-345222-otfnrarh 198 22 infants infant NNS cord-345222-otfnrarh 198 23 the the DT cord-345222-otfnrarh 198 24 infection infection NN cord-345222-otfnrarh 198 25 spreads spread VBZ cord-345222-otfnrarh 198 26 rapidly rapidly RB cord-345222-otfnrarh 198 27 and and CC cord-345222-otfnrarh 198 28 can can MD cord-345222-otfnrarh 198 29 be be VB cord-345222-otfnrarh 198 30 associated associate VBN cord-345222-otfnrarh 198 31 with with IN cord-345222-otfnrarh 198 32 a a DT cord-345222-otfnrarh 198 33 poor poor JJ cord-345222-otfnrarh 198 34 prognosis prognosis NN cord-345222-otfnrarh 198 35 and and CC cord-345222-otfnrarh 198 36 high high JJ cord-345222-otfnrarh 198 37 morbidity morbidity NN cord-345222-otfnrarh 198 38 . . . cord-345222-otfnrarh 199 1 5 5 CD cord-345222-otfnrarh 199 2 Cytomegalovirus Cytomegalovirus NNP cord-345222-otfnrarh 199 3 and and CC cord-345222-otfnrarh 199 4 herpes herpes NN cord-345222-otfnrarh 199 5 virus virus NN cord-345222-otfnrarh 199 6 ( ( -LRB- cord-345222-otfnrarh 199 7 CMV CMV NNP cord-345222-otfnrarh 199 8 or or CC cord-345222-otfnrarh 199 9 HH5 HH5 NNP cord-345222-otfnrarh 199 10 and and CC cord-345222-otfnrarh 199 11 HHV6 HHV6 NNP cord-345222-otfnrarh 199 12 - - HYPH cord-345222-otfnrarh 199 13 7 7 CD cord-345222-otfnrarh 199 14 ; ; , cord-345222-otfnrarh 199 15 family family NN cord-345222-otfnrarh 199 16 Herpesviridae Herpesviridae NNP cord-345222-otfnrarh 199 17 , , , cord-345222-otfnrarh 199 18 subfamily subfamily NN cord-345222-otfnrarh 199 19 Betaherpesviridae Betaherpesviridae NNP cord-345222-otfnrarh 199 20 ) ) -RRB- cord-345222-otfnrarh 199 21 can can MD cord-345222-otfnrarh 199 22 cause cause VB cord-345222-otfnrarh 199 23 gastrointestinal gastrointestinal JJ cord-345222-otfnrarh 199 24 symptoms symptom NNS cord-345222-otfnrarh 199 25 such such JJ cord-345222-otfnrarh 199 26 as as IN cord-345222-otfnrarh 199 27 diarrhea diarrhea NN cord-345222-otfnrarh 199 28 or or CC cord-345222-otfnrarh 199 29 colitis colitis NN cord-345222-otfnrarh 199 30 with with IN cord-345222-otfnrarh 199 31 profuse profuse JJ cord-345222-otfnrarh 199 32 hematochezia hematochezia NN cord-345222-otfnrarh 199 33 and and CC cord-345222-otfnrarh 199 34 bowel bowel NN cord-345222-otfnrarh 199 35 perforation perforation NN cord-345222-otfnrarh 199 36 . . . cord-345222-otfnrarh 200 1 62 62 CD cord-345222-otfnrarh 201 1 Most Most JJS cord-345222-otfnrarh 201 2 people people NNS cord-345222-otfnrarh 201 3 who who WP cord-345222-otfnrarh 201 4 are be VBP cord-345222-otfnrarh 201 5 infected infect VBN cord-345222-otfnrarh 201 6 with with IN cord-345222-otfnrarh 201 7 a a DT cord-345222-otfnrarh 201 8 non non JJ cord-345222-otfnrarh 201 9 - - JJ cord-345222-otfnrarh 201 10 polio polio JJ cord-345222-otfnrarh 201 11 enterovirus enterovirus NN cord-345222-otfnrarh 201 12 ( ( -LRB- cord-345222-otfnrarh 201 13 EV ev NN cord-345222-otfnrarh 201 14 ; ; , cord-345222-otfnrarh 201 15 family family NN cord-345222-otfnrarh 201 16 Picornaviridae Picornaviridae NNP cord-345222-otfnrarh 201 17 , , , cord-345222-otfnrarh 201 18 genus genus NN cord-345222-otfnrarh 201 19 Enterovirus enterovirus NN cord-345222-otfnrarh 201 20 ) ) -RRB- cord-345222-otfnrarh 201 21 have have VBP cord-345222-otfnrarh 201 22 no no DT cord-345222-otfnrarh 201 23 disease disease NN cord-345222-otfnrarh 201 24 , , , cord-345222-otfnrarh 201 25 but but CC cord-345222-otfnrarh 201 26 all all DT cord-345222-otfnrarh 201 27 EV EV NNP cord-345222-otfnrarh 201 28 may may MD cord-345222-otfnrarh 201 29 cause cause VB cord-345222-otfnrarh 201 30 diarrhea diarrhea NN cord-345222-otfnrarh 201 31 . . . cord-345222-otfnrarh 202 1 63 63 CD cord-345222-otfnrarh 202 2 Human Human NNP cord-345222-otfnrarh 202 3 EV EV NNP cord-345222-otfnrarh 202 4 68 68 CD cord-345222-otfnrarh 203 1 ( ( -LRB- cord-345222-otfnrarh 203 2 EV EV NNP cord-345222-otfnrarh 203 3 - - HYPH cord-345222-otfnrarh 203 4 D68 D68 NNP cord-345222-otfnrarh 203 5 ) ) -RRB- cord-345222-otfnrarh 203 6 is be VBZ cord-345222-otfnrarh 203 7 a a DT cord-345222-otfnrarh 203 8 historically historically RB cord-345222-otfnrarh 203 9 rarely rarely RB cord-345222-otfnrarh 203 10 reported report VBN cord-345222-otfnrarh 203 11 virus virus NN cord-345222-otfnrarh 203 12 linked link VBN cord-345222-otfnrarh 203 13 with with IN cord-345222-otfnrarh 203 14 respiratory respiratory JJ cord-345222-otfnrarh 203 15 disease disease NN cord-345222-otfnrarh 203 16 . . . cord-345222-otfnrarh 204 1 In in IN cord-345222-otfnrarh 204 2 the the DT cord-345222-otfnrarh 204 3 last last JJ cord-345222-otfnrarh 204 4 3 3 CD cord-345222-otfnrarh 204 5 years year NNS cord-345222-otfnrarh 204 6 , , , cord-345222-otfnrarh 204 7 a a DT cord-345222-otfnrarh 204 8 large large JJ cord-345222-otfnrarh 204 9 increase increase NN cord-345222-otfnrarh 204 10 in in IN cord-345222-otfnrarh 204 11 respiratory respiratory JJ cord-345222-otfnrarh 204 12 disease disease NN cord-345222-otfnrarh 204 13 associated associate VBN cord-345222-otfnrarh 204 14 with with IN cord-345222-otfnrarh 204 15 EV EV NNP cord-345222-otfnrarh 204 16 - - HYPH cord-345222-otfnrarh 204 17 D68 D68 NNP cord-345222-otfnrarh 204 18 has have VBZ cord-345222-otfnrarh 204 19 been be VBN cord-345222-otfnrarh 204 20 reported report VBN cord-345222-otfnrarh 204 21 , , , cord-345222-otfnrarh 204 22 with with IN cord-345222-otfnrarh 204 23 documented document VBN cord-345222-otfnrarh 204 24 outbreaks outbreak NNS cord-345222-otfnrarh 204 25 in in IN cord-345222-otfnrarh 204 26 North North NNP cord-345222-otfnrarh 204 27 America America NNP cord-345222-otfnrarh 204 28 , , , cord-345222-otfnrarh 204 29 Europe Europe NNP cord-345222-otfnrarh 204 30 , , , cord-345222-otfnrarh 204 31 and and CC cord-345222-otfnrarh 204 32 Asia Asia NNP cord-345222-otfnrarh 204 33 . . . cord-345222-otfnrarh 205 1 64 64 CD cord-345222-otfnrarh 205 2 EV71 EV71 NNP cord-345222-otfnrarh 205 3 infections infection NNS cord-345222-otfnrarh 205 4 can can MD cord-345222-otfnrarh 205 5 be be VB cord-345222-otfnrarh 205 6 asymptomatic asymptomatic JJ cord-345222-otfnrarh 205 7 or or CC cord-345222-otfnrarh 205 8 can can MD cord-345222-otfnrarh 205 9 cause cause VB cord-345222-otfnrarh 205 10 diarrhea diarrhea NN cord-345222-otfnrarh 205 11 , , , cord-345222-otfnrarh 205 12 rashes rash NNS cord-345222-otfnrarh 205 13 , , , cord-345222-otfnrarh 205 14 and and CC cord-345222-otfnrarh 205 15 hand hand NN cord-345222-otfnrarh 205 16 , , , cord-345222-otfnrarh 205 17 foot foot NN cord-345222-otfnrarh 205 18 , , , cord-345222-otfnrarh 205 19 and and CC cord-345222-otfnrarh 205 20 mouth mouth NN cord-345222-otfnrarh 205 21 disease disease NN cord-345222-otfnrarh 205 22 . . . cord-345222-otfnrarh 206 1 However however RB cord-345222-otfnrarh 206 2 , , , cord-345222-otfnrarh 206 3 EV71 EV71 NNP cord-345222-otfnrarh 206 4 may may MD cord-345222-otfnrarh 206 5 be be VB cord-345222-otfnrarh 206 6 responsible responsible JJ cord-345222-otfnrarh 206 7 for for IN cord-345222-otfnrarh 206 8 severe severe JJ cord-345222-otfnrarh 206 9 complications complication NNS cord-345222-otfnrarh 206 10 , , , cord-345222-otfnrarh 206 11 including include VBG cord-345222-otfnrarh 206 12 meningitis meningitis NN cord-345222-otfnrarh 206 13 , , , cord-345222-otfnrarh 206 14 encephalitis encephalitis RB cord-345222-otfnrarh 206 15 , , , cord-345222-otfnrarh 206 16 cardiovascular cardiovascular JJ cord-345222-otfnrarh 206 17 and and CC cord-345222-otfnrarh 206 18 respiratory respiratory JJ cord-345222-otfnrarh 206 19 problems problem NNS cord-345222-otfnrarh 206 20 as as IN cord-345222-otfnrarh 206 21 pulmonary pulmonary JJ cord-345222-otfnrarh 206 22 edema edema NN cord-345222-otfnrarh 206 23 , , , cord-345222-otfnrarh 206 24 or or CC cord-345222-otfnrarh 206 25 heart heart NN cord-345222-otfnrarh 206 26 failure failure NN cord-345222-otfnrarh 206 27 . . . cord-345222-otfnrarh 207 1 Cases case NNS cord-345222-otfnrarh 207 2 of of IN cord-345222-otfnrarh 207 3 fatal fatal JJ cord-345222-otfnrarh 207 4 EV71 EV71 NNP cord-345222-otfnrarh 207 5 encephalitis encephaliti NNS cord-345222-otfnrarh 207 6 have have VBP cord-345222-otfnrarh 207 7 occurred occur VBN cord-345222-otfnrarh 207 8 during during IN cord-345222-otfnrarh 207 9 outbreaks outbreak NNS cord-345222-otfnrarh 207 10 . . . cord-345222-otfnrarh 208 1 Most Most JJS cord-345222-otfnrarh 208 2 EV71 EV71 NNP cord-345222-otfnrarh 208 3 infections infection NNS cord-345222-otfnrarh 208 4 occur occur VBP cord-345222-otfnrarh 208 5 under under IN cord-345222-otfnrarh 208 6 3 3 CD cord-345222-otfnrarh 208 7 years year NNS cord-345222-otfnrarh 208 8 of of IN cord-345222-otfnrarh 208 9 age age NN cord-345222-otfnrarh 208 10 . . . cord-345222-otfnrarh 209 1 Coxsackie Coxsackie NNP cord-345222-otfnrarh 209 2 ( ( -LRB- cord-345222-otfnrarh 209 3 family family NN cord-345222-otfnrarh 209 4 Picornaviridae Picornaviridae NNP cord-345222-otfnrarh 209 5 , , , cord-345222-otfnrarh 209 6 genus genus NN cord-345222-otfnrarh 209 7 Enterovirus)-A16 enterovirus)-a16 NN cord-345222-otfnrarh 209 8 and and CC cord-345222-otfnrarh 209 9 EV71 EV71 NNP cord-345222-otfnrarh 209 10 are be VBP cord-345222-otfnrarh 209 11 two two CD cord-345222-otfnrarh 209 12 of of IN cord-345222-otfnrarh 209 13 the the DT cord-345222-otfnrarh 209 14 major major JJ cord-345222-otfnrarh 209 15 pathogens pathogen NNS cord-345222-otfnrarh 209 16 responsible responsible JJ cord-345222-otfnrarh 209 17 for for IN cord-345222-otfnrarh 209 18 hand hand NN cord-345222-otfnrarh 209 19 , , , cord-345222-otfnrarh 209 20 foot foot NN cord-345222-otfnrarh 209 21 , , , cord-345222-otfnrarh 209 22 and and CC cord-345222-otfnrarh 209 23 mouth mouth NN cord-345222-otfnrarh 209 24 disease disease NN cord-345222-otfnrarh 209 25 , , , cord-345222-otfnrarh 209 26 but but CC cord-345222-otfnrarh 209 27 the the DT cord-345222-otfnrarh 209 28 most most RBS cord-345222-otfnrarh 209 29 severe severe JJ cord-345222-otfnrarh 209 30 cases case NNS cord-345222-otfnrarh 209 31 are be VBP cord-345222-otfnrarh 209 32 associated associate VBN cord-345222-otfnrarh 209 33 with with IN cord-345222-otfnrarh 209 34 EV71 EV71 NNP cord-345222-otfnrarh 209 35 . . . cord-345222-otfnrarh 210 1 65 65 CD cord-345222-otfnrarh 210 2 , , , cord-345222-otfnrarh 210 3 66 66 CD cord-345222-otfnrarh 211 1 Pleconaril Pleconaril NNP cord-345222-otfnrarh 211 2 , , , cord-345222-otfnrarh 211 3 a a DT cord-345222-otfnrarh 211 4 viral viral JJ cord-345222-otfnrarh 211 5 agent agent NN cord-345222-otfnrarh 211 6 active active JJ cord-345222-otfnrarh 211 7 against against IN cord-345222-otfnrarh 211 8 enteroviruses enteroviruses NNP cord-345222-otfnrarh 211 9 , , , cord-345222-otfnrarh 211 10 has have VBZ cord-345222-otfnrarh 211 11 demonstrated demonstrate VBN cord-345222-otfnrarh 211 12 efficacy efficacy NN cord-345222-otfnrarh 211 13 against against IN cord-345222-otfnrarh 211 14 neonatal neonatal JJ cord-345222-otfnrarh 211 15 infection infection NN cord-345222-otfnrarh 211 16 with with IN cord-345222-otfnrarh 211 17 systemic systemic JJ cord-345222-otfnrarh 211 18 symptoms symptom NNS cord-345222-otfnrarh 211 19 . . . cord-345222-otfnrarh 212 1 However however RB cord-345222-otfnrarh 212 2 , , , cord-345222-otfnrarh 212 3 further further JJ cord-345222-otfnrarh 212 4 confirmatory confirmatory JJ cord-345222-otfnrarh 212 5 studies study NNS cord-345222-otfnrarh 212 6 are be VBP cord-345222-otfnrarh 212 7 needed need VBN cord-345222-otfnrarh 212 8 . . . cord-345222-otfnrarh 213 1 67 67 CD cord-345222-otfnrarh 213 2 Results result NNS cord-345222-otfnrarh 213 3 of of IN cord-345222-otfnrarh 213 4 Phase phase NN cord-345222-otfnrarh 214 1 I -PRON- PRP cord-345222-otfnrarh 214 2 clinical clinical JJ cord-345222-otfnrarh 214 3 trials trial NNS cord-345222-otfnrarh 214 4 suggest suggest VBP cord-345222-otfnrarh 214 5 an an DT cord-345222-otfnrarh 214 6 EV71 EV71 NNP cord-345222-otfnrarh 214 7 vaccine vaccine NN cord-345222-otfnrarh 214 8 has have VBZ cord-345222-otfnrarh 214 9 a a DT cord-345222-otfnrarh 214 10 clinically clinically RB cord-345222-otfnrarh 214 11 acceptable acceptable JJ cord-345222-otfnrarh 214 12 safety safety NN cord-345222-otfnrarh 214 13 profile profile NN cord-345222-otfnrarh 214 14 and and CC cord-345222-otfnrarh 214 15 immunogenicity immunogenicity NN cord-345222-otfnrarh 214 16 . . . cord-345222-otfnrarh 215 1 Outbreaks outbreak NNS cord-345222-otfnrarh 215 2 of of IN cord-345222-otfnrarh 215 3 EV71 EV71 NNP cord-345222-otfnrarh 215 4 are be VBP cord-345222-otfnrarh 215 5 a a DT cord-345222-otfnrarh 215 6 serious serious JJ cord-345222-otfnrarh 215 7 socioeconomic socioeconomic JJ cord-345222-otfnrarh 215 8 burden burden NN cord-345222-otfnrarh 215 9 not not RB cord-345222-otfnrarh 215 10 only only RB cord-345222-otfnrarh 215 11 in in IN cord-345222-otfnrarh 215 12 the the DT cord-345222-otfnrarh 215 13 Western Western NNP cord-345222-otfnrarh 215 14 Pacific Pacific NNP cord-345222-otfnrarh 215 15 region region NN cord-345222-otfnrarh 215 16 . . . cord-345222-otfnrarh 216 1 For for IN cord-345222-otfnrarh 216 2 this this DT cord-345222-otfnrarh 216 3 reason reason NN cord-345222-otfnrarh 216 4 , , , cord-345222-otfnrarh 216 5 an an DT cord-345222-otfnrarh 216 6 EV71 EV71 NNP cord-345222-otfnrarh 216 7 vaccine vaccine NN cord-345222-otfnrarh 216 8 is be VBZ cord-345222-otfnrarh 216 9 now now RB cord-345222-otfnrarh 216 10 being be VBG cord-345222-otfnrarh 216 11 tested test VBN cord-345222-otfnrarh 216 12 and and CC cord-345222-otfnrarh 216 13 seems seem VBZ cord-345222-otfnrarh 216 14 to to TO cord-345222-otfnrarh 216 15 submit submit VB cord-345222-otfnrarh 216 16 your -PRON- PRP$ cord-345222-otfnrarh 216 17 manuscript manuscript NN cord-345222-otfnrarh 216 18 | | NNP cord-345222-otfnrarh 216 19 www.dovepress.com www.dovepress.com NNP cord-345222-otfnrarh 216 20 have have VBP cord-345222-otfnrarh 216 21 an an DT cord-345222-otfnrarh 216 22 acceptable acceptable JJ cord-345222-otfnrarh 216 23 safety safety NN cord-345222-otfnrarh 216 24 profile profile NN cord-345222-otfnrarh 216 25 and and CC cord-345222-otfnrarh 216 26 clinically clinically RB cord-345222-otfnrarh 216 27 acceptable acceptable JJ cord-345222-otfnrarh 216 28 immunogenicity immunogenicity NN cord-345222-otfnrarh 216 29 . . . cord-345222-otfnrarh 217 1 68 68 CD cord-345222-otfnrarh 217 2 Human Human NNP cord-345222-otfnrarh 217 3 astrovirus astrovirus NNP cord-345222-otfnrarh 217 4 ( ( -LRB- cord-345222-otfnrarh 217 5 family family NN cord-345222-otfnrarh 217 6 Astroviridae Astroviridae NNP cord-345222-otfnrarh 217 7 , , , cord-345222-otfnrarh 217 8 genus genus NN cord-345222-otfnrarh 217 9 Mamastrovirus Mamastrovirus NNP cord-345222-otfnrarh 217 10 ) ) -RRB- cord-345222-otfnrarh 217 11 may may MD cord-345222-otfnrarh 217 12 also also RB cord-345222-otfnrarh 217 13 be be VB cord-345222-otfnrarh 217 14 responsible responsible JJ cord-345222-otfnrarh 217 15 for for IN cord-345222-otfnrarh 217 16 sporadic sporadic JJ cord-345222-otfnrarh 217 17 infections infection NNS cord-345222-otfnrarh 217 18 or or CC cord-345222-otfnrarh 217 19 epidemics epidemic NNS cord-345222-otfnrarh 217 20 , , , cord-345222-otfnrarh 217 21 occasionally occasionally RB cord-345222-otfnrarh 217 22 in in IN cord-345222-otfnrarh 217 23 newborns newborn NNS cord-345222-otfnrarh 217 24 and and CC cord-345222-otfnrarh 217 25 children child NNS cord-345222-otfnrarh 217 26 . . . cord-345222-otfnrarh 218 1 61 61 CD cord-345222-otfnrarh 218 2 , , , cord-345222-otfnrarh 218 3 63 63 CD cord-345222-otfnrarh 218 4 Human Human NNP cord-345222-otfnrarh 218 5 bocavirus bocavirus NNP cord-345222-otfnrarh 218 6 ( ( -LRB- cord-345222-otfnrarh 218 7 family family NN cord-345222-otfnrarh 218 8 Parvoviridae Parvoviridae NNP cord-345222-otfnrarh 218 9 , , , cord-345222-otfnrarh 218 10 genus genus NN cord-345222-otfnrarh 218 11 Bocavirus Bocavirus NNP cord-345222-otfnrarh 218 12 ) ) -RRB- cord-345222-otfnrarh 218 13 , , , cord-345222-otfnrarh 218 14 recently recently RB cord-345222-otfnrarh 218 15 discovered discover VBN cord-345222-otfnrarh 218 16 , , , cord-345222-otfnrarh 218 17 has have VBZ cord-345222-otfnrarh 218 18 been be VBN cord-345222-otfnrarh 218 19 suggested suggest VBN cord-345222-otfnrarh 218 20 to to TO cord-345222-otfnrarh 218 21 be be VB cord-345222-otfnrarh 218 22 involved involve VBN cord-345222-otfnrarh 218 23 in in IN cord-345222-otfnrarh 218 24 a a DT cord-345222-otfnrarh 218 25 large large JJ cord-345222-otfnrarh 218 26 spectrum spectrum NN cord-345222-otfnrarh 218 27 of of IN cord-345222-otfnrarh 218 28 clinical clinical JJ cord-345222-otfnrarh 218 29 manifestations manifestation NNS cord-345222-otfnrarh 218 30 , , , cord-345222-otfnrarh 218 31 including include VBG cord-345222-otfnrarh 218 32 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 218 33 . . . cord-345222-otfnrarh 219 1 63 63 CD cord-345222-otfnrarh 219 2 , , , cord-345222-otfnrarh 219 3 69 69 CD cord-345222-otfnrarh 219 4 Human Human NNP cord-345222-otfnrarh 219 5 coronaviruses coronaviruse NNS cord-345222-otfnrarh 219 6 ( ( -LRB- cord-345222-otfnrarh 219 7 HCoVs HCoVs NNP cord-345222-otfnrarh 219 8 ; ; : cord-345222-otfnrarh 219 9 family family NN cord-345222-otfnrarh 219 10 Coronaviridae Coronaviridae NNP cord-345222-otfnrarh 219 11 , , , cord-345222-otfnrarh 219 12 genus genus NN cord-345222-otfnrarh 219 13 Coronavirus Coronavirus NNP cord-345222-otfnrarh 219 14 ) ) -RRB- cord-345222-otfnrarh 219 15 are be VBP cord-345222-otfnrarh 219 16 common common JJ cord-345222-otfnrarh 219 17 causes cause NNS cord-345222-otfnrarh 219 18 of of IN cord-345222-otfnrarh 219 19 upper upper JJ cord-345222-otfnrarh 219 20 respiratory respiratory JJ cord-345222-otfnrarh 219 21 tract tract NN cord-345222-otfnrarh 219 22 infections infection NNS cord-345222-otfnrarh 219 23 . . . cord-345222-otfnrarh 220 1 A a DT cord-345222-otfnrarh 220 2 new new JJ cord-345222-otfnrarh 220 3 coronavirus coronavirus NN cord-345222-otfnrarh 220 4 was be VBD cord-345222-otfnrarh 220 5 found find VBN cord-345222-otfnrarh 220 6 to to TO cord-345222-otfnrarh 220 7 be be VB cord-345222-otfnrarh 220 8 a a DT cord-345222-otfnrarh 220 9 causative causative JJ cord-345222-otfnrarh 220 10 agent agent NN cord-345222-otfnrarh 220 11 of of IN cord-345222-otfnrarh 220 12 severe severe JJ cord-345222-otfnrarh 220 13 acute acute JJ cord-345222-otfnrarh 220 14 respiratory respiratory JJ cord-345222-otfnrarh 220 15 syndrome syndrome NN cord-345222-otfnrarh 220 16 ( ( -LRB- cord-345222-otfnrarh 220 17 SARS SARS NNP cord-345222-otfnrarh 220 18 ) ) -RRB- cord-345222-otfnrarh 220 19 . . . cord-345222-otfnrarh 221 1 SARS SARS NNP cord-345222-otfnrarh 221 2 - - HYPH cord-345222-otfnrarh 221 3 HCoV HCoV NNP cord-345222-otfnrarh 221 4 caused cause VBD cord-345222-otfnrarh 221 5 a a DT cord-345222-otfnrarh 221 6 serious serious JJ cord-345222-otfnrarh 221 7 lower low JJR cord-345222-otfnrarh 221 8 respiratory respiratory JJ cord-345222-otfnrarh 221 9 tract tract NN cord-345222-otfnrarh 221 10 infection infection NN cord-345222-otfnrarh 221 11 with with IN cord-345222-otfnrarh 221 12 high high JJ cord-345222-otfnrarh 221 13 mortality mortality NN cord-345222-otfnrarh 221 14 . . . cord-345222-otfnrarh 222 1 Diarrhea diarrhea NN cord-345222-otfnrarh 222 2 is be VBZ cord-345222-otfnrarh 222 3 common common JJ cord-345222-otfnrarh 222 4 in in IN cord-345222-otfnrarh 222 5 this this DT cord-345222-otfnrarh 222 6 condition condition NN cord-345222-otfnrarh 222 7 , , , cord-345222-otfnrarh 222 8 and and CC cord-345222-otfnrarh 222 9 in in IN cord-345222-otfnrarh 222 10 one one CD cord-345222-otfnrarh 222 11 study study NN cord-345222-otfnrarh 222 12 was be VBD cord-345222-otfnrarh 222 13 registered register VBN cord-345222-otfnrarh 222 14 in in IN cord-345222-otfnrarh 222 15 38.4 38.4 CD cord-345222-otfnrarh 222 16 % % NN cord-345222-otfnrarh 222 17 of of IN cord-345222-otfnrarh 222 18 patients patient NNS cord-345222-otfnrarh 222 19 . . . cord-345222-otfnrarh 223 1 In in IN cord-345222-otfnrarh 223 2 the the DT cord-345222-otfnrarh 223 3 same same JJ cord-345222-otfnrarh 223 4 study study NN cord-345222-otfnrarh 223 5 , , , cord-345222-otfnrarh 223 6 SARS SARS NNP cord-345222-otfnrarh 223 7 - - HYPH cord-345222-otfnrarh 223 8 HCoV HCoV NNP cord-345222-otfnrarh 223 9 was be VBD cord-345222-otfnrarh 223 10 also also RB cord-345222-otfnrarh 223 11 isolated isolate VBN cord-345222-otfnrarh 223 12 from from IN cord-345222-otfnrarh 223 13 intestinal intestinal JJ cord-345222-otfnrarh 223 14 tissue tissue NN cord-345222-otfnrarh 223 15 , , , cord-345222-otfnrarh 223 16 and and CC cord-345222-otfnrarh 223 17 viral viral JJ cord-345222-otfnrarh 223 18 RNA RNA NNP cord-345222-otfnrarh 223 19 was be VBD cord-345222-otfnrarh 223 20 detected detect VBN cord-345222-otfnrarh 223 21 in in IN cord-345222-otfnrarh 223 22 stool stool NN cord-345222-otfnrarh 223 23 samples sample NNS cord-345222-otfnrarh 223 24 . . . cord-345222-otfnrarh 224 1 Moreover moreover RB cord-345222-otfnrarh 224 2 , , , cord-345222-otfnrarh 224 3 non non JJ cord-345222-otfnrarh 224 4 - - JJ cord-345222-otfnrarh 224 5 SARS sars JJ cord-345222-otfnrarh 224 6 HCoVs hcovs NN cord-345222-otfnrarh 224 7 can can MD cord-345222-otfnrarh 224 8 be be VB cord-345222-otfnrarh 224 9 found find VBN cord-345222-otfnrarh 224 10 in in IN cord-345222-otfnrarh 224 11 stool stool NN cord-345222-otfnrarh 224 12 samples sample NNS cord-345222-otfnrarh 224 13 of of IN cord-345222-otfnrarh 224 14 children child NNS cord-345222-otfnrarh 224 15 with with IN cord-345222-otfnrarh 224 16 AGE AGE NNP cord-345222-otfnrarh 224 17 . . . cord-345222-otfnrarh 225 1 However however RB cord-345222-otfnrarh 225 2 , , , cord-345222-otfnrarh 225 3 most most JJS cord-345222-otfnrarh 225 4 of of IN cord-345222-otfnrarh 225 5 the the DT cord-345222-otfnrarh 225 6 HCoV HCoV NNP cord-345222-otfnrarh 225 7 findings finding NNS cord-345222-otfnrarh 225 8 were be VBD cord-345222-otfnrarh 225 9 coinfections coinfection NNS cord-345222-otfnrarh 225 10 with with IN cord-345222-otfnrarh 225 11 well well RB cord-345222-otfnrarh 225 12 - - HYPH cord-345222-otfnrarh 225 13 known know VBN cord-345222-otfnrarh 225 14 enteric enteric JJ cord-345222-otfnrarh 225 15 pathogens pathogen NNS cord-345222-otfnrarh 225 16 -norovirus -norovirus CD cord-345222-otfnrarh 225 17 and and CC cord-345222-otfnrarh 225 18 rotavirus rotavirus NN cord-345222-otfnrarh 225 19 . . . cord-345222-otfnrarh 226 1 It -PRON- PRP cord-345222-otfnrarh 226 2 is be VBZ cord-345222-otfnrarh 226 3 also also RB cord-345222-otfnrarh 226 4 difficult difficult JJ cord-345222-otfnrarh 226 5 to to TO cord-345222-otfnrarh 226 6 determine determine VB cord-345222-otfnrarh 226 7 whether whether IN cord-345222-otfnrarh 226 8 HCoVs HCoVs NNP cord-345222-otfnrarh 226 9 in in IN cord-345222-otfnrarh 226 10 the the DT cord-345222-otfnrarh 226 11 respiratory respiratory JJ cord-345222-otfnrarh 226 12 tract tract NN cord-345222-otfnrarh 226 13 in in IN cord-345222-otfnrarh 226 14 cases case NNS cord-345222-otfnrarh 226 15 of of IN cord-345222-otfnrarh 226 16 AGE AGE NNP cord-345222-otfnrarh 226 17 were be VBD cord-345222-otfnrarh 226 18 primarily primarily RB cord-345222-otfnrarh 226 19 causing cause VBG cord-345222-otfnrarh 226 20 the the DT cord-345222-otfnrarh 226 21 respiratory respiratory JJ cord-345222-otfnrarh 226 22 or or CC cord-345222-otfnrarh 226 23 gastrointestinal gastrointestinal JJ cord-345222-otfnrarh 226 24 symptoms symptom NNS cord-345222-otfnrarh 226 25 . . . cord-345222-otfnrarh 227 1 HCoVs HCoVs NNP cord-345222-otfnrarh 227 2 may may MD cord-345222-otfnrarh 227 3 also also RB cord-345222-otfnrarh 227 4 be be VB cord-345222-otfnrarh 227 5 found find VBN cord-345222-otfnrarh 227 6 in in IN cord-345222-otfnrarh 227 7 occasional occasional JJ cord-345222-otfnrarh 227 8 stool stool NN cord-345222-otfnrarh 227 9 samples sample NNS cord-345222-otfnrarh 227 10 of of IN cord-345222-otfnrarh 227 11 children child NNS cord-345222-otfnrarh 227 12 without without IN cord-345222-otfnrarh 227 13 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 227 14 . . . cord-345222-otfnrarh 228 1 These these DT cord-345222-otfnrarh 228 2 findings finding NNS cord-345222-otfnrarh 228 3 suggest suggest VBP cord-345222-otfnrarh 228 4 that that IN cord-345222-otfnrarh 228 5 known know VBN cord-345222-otfnrarh 228 6 HCoVs hcovs CD cord-345222-otfnrarh 228 7 may may MD cord-345222-otfnrarh 228 8 at at RB cord-345222-otfnrarh 228 9 most most JJS cord-345222-otfnrarh 228 10 have have VB cord-345222-otfnrarh 228 11 a a DT cord-345222-otfnrarh 228 12 minor minor JJ cord-345222-otfnrarh 228 13 etiologic etiologic JJ cord-345222-otfnrarh 228 14 role role NN cord-345222-otfnrarh 228 15 in in IN cord-345222-otfnrarh 228 16 AGE age NN cord-345222-otfnrarh 228 17 of of IN cord-345222-otfnrarh 228 18 children child NNS cord-345222-otfnrarh 228 19 . . . cord-345222-otfnrarh 229 1 70 70 CD cord-345222-otfnrarh 229 2 Human human JJ cord-345222-otfnrarh 229 3 rotavirus rotavirus NN cord-345222-otfnrarh 229 4 ( ( -LRB- cord-345222-otfnrarh 229 5 family family NN cord-345222-otfnrarh 229 6 Reoviridae Reoviridae NNP cord-345222-otfnrarh 229 7 , , , cord-345222-otfnrarh 229 8 genus genus JJ cord-345222-otfnrarh 229 9 Rotavirus rotavirus NN cord-345222-otfnrarh 229 10 ) ) -RRB- cord-345222-otfnrarh 229 11 in in IN cord-345222-otfnrarh 229 12 the the DT cord-345222-otfnrarh 229 13 past past NN cord-345222-otfnrarh 229 14 was be VBD cord-345222-otfnrarh 229 15 considered consider VBN cord-345222-otfnrarh 229 16 to to TO cord-345222-otfnrarh 229 17 be be VB cord-345222-otfnrarh 229 18 responsible responsible JJ cord-345222-otfnrarh 229 19 for for IN cord-345222-otfnrarh 229 20 the the DT cord-345222-otfnrarh 229 21 most most RBS cord-345222-otfnrarh 229 22 severe severe JJ cord-345222-otfnrarh 229 23 episodes episode NNS cord-345222-otfnrarh 229 24 of of IN cord-345222-otfnrarh 229 25 diarrhea diarrhea NN cord-345222-otfnrarh 229 26 in in IN cord-345222-otfnrarh 229 27 children child NNS cord-345222-otfnrarh 229 28 . . . cord-345222-otfnrarh 230 1 71 71 CD cord-345222-otfnrarh 230 2 , , , cord-345222-otfnrarh 230 3 72 72 CD cord-345222-otfnrarh 230 4 There there EX cord-345222-otfnrarh 230 5 have have VBP cord-345222-otfnrarh 230 6 been be VBN cord-345222-otfnrarh 230 7 reports report NNS cord-345222-otfnrarh 230 8 of of IN cord-345222-otfnrarh 230 9 epidemics epidemic NNS cord-345222-otfnrarh 230 10 in in IN cord-345222-otfnrarh 230 11 neonatal neonatal JJ cord-345222-otfnrarh 230 12 intensive intensive JJ cord-345222-otfnrarh 230 13 care care NN cord-345222-otfnrarh 230 14 units unit NNS cord-345222-otfnrarh 230 15 caused cause VBN cord-345222-otfnrarh 230 16 by by IN cord-345222-otfnrarh 230 17 rotavirus rotavirus NN cord-345222-otfnrarh 230 18 or or CC cord-345222-otfnrarh 230 19 enterovirus enterovirus NN cord-345222-otfnrarh 230 20 that that WDT cord-345222-otfnrarh 230 21 can can MD cord-345222-otfnrarh 230 22 determine determine VB cord-345222-otfnrarh 230 23 cases case NNS cord-345222-otfnrarh 230 24 of of IN cord-345222-otfnrarh 230 25 necrotizing necrotize VBG cord-345222-otfnrarh 230 26 enterocolitis enterocolitis NN cord-345222-otfnrarh 230 27 or or CC cord-345222-otfnrarh 230 28 necrotizing necrotize VBG cord-345222-otfnrarh 230 29 enterocolitis enterocolitis NN cord-345222-otfnrarh 230 30 - - HYPH cord-345222-otfnrarh 230 31 like like JJ cord-345222-otfnrarh 230 32 symptoms symptom NNS cord-345222-otfnrarh 230 33 : : : cord-345222-otfnrarh 230 34 abdominal abdominal JJ cord-345222-otfnrarh 230 35 distention distention NN cord-345222-otfnrarh 230 36 , , , cord-345222-otfnrarh 230 37 bloody bloody JJ cord-345222-otfnrarh 230 38 diarrhea diarrhea NN cord-345222-otfnrarh 230 39 , , , cord-345222-otfnrarh 230 40 and and CC cord-345222-otfnrarh 230 41 septicemia septicemia NN cord-345222-otfnrarh 230 42 secondary secondary JJ cord-345222-otfnrarh 230 43 to to IN cord-345222-otfnrarh 230 44 enteric enteric JJ cord-345222-otfnrarh 230 45 bacteria bacteria NNS cord-345222-otfnrarh 230 46 . . . cord-345222-otfnrarh 231 1 Improved improve VBN cord-345222-otfnrarh 231 2 diagnostic diagnostic JJ cord-345222-otfnrarh 231 3 tools tool NNS cord-345222-otfnrarh 231 4 for for IN cord-345222-otfnrarh 231 5 norovirus norovirus NN cord-345222-otfnrarh 231 6 ( ( -LRB- cord-345222-otfnrarh 231 7 family family NN cord-345222-otfnrarh 231 8 Caliciviridae Caliciviridae NNP cord-345222-otfnrarh 231 9 , , , cord-345222-otfnrarh 231 10 genus genus NN cord-345222-otfnrarh 231 11 Norovirus norovirus NN cord-345222-otfnrarh 231 12 ) ) -RRB- cord-345222-otfnrarh 231 13 : : : cord-345222-otfnrarh 231 14 have have VBP cord-345222-otfnrarh 231 15 shown show VBN cord-345222-otfnrarh 231 16 that that IN cord-345222-otfnrarh 231 17 it -PRON- PRP cord-345222-otfnrarh 231 18 has have VBZ cord-345222-otfnrarh 231 19 a a DT cord-345222-otfnrarh 231 20 major major JJ cord-345222-otfnrarh 231 21 role role NN cord-345222-otfnrarh 231 22 in in IN cord-345222-otfnrarh 231 23 both both DT cord-345222-otfnrarh 231 24 epidemic epidemic NN cord-345222-otfnrarh 231 25 and and CC cord-345222-otfnrarh 231 26 sporadic sporadic JJ cord-345222-otfnrarh 231 27 cases case NNS cord-345222-otfnrarh 231 28 of of IN cord-345222-otfnrarh 231 29 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 231 30 . . . cord-345222-otfnrarh 232 1 59 59 CD cord-345222-otfnrarh 232 2 , , , cord-345222-otfnrarh 232 3 73 73 CD cord-345222-otfnrarh 232 4 Sapoviruses Sapoviruses NNPS cord-345222-otfnrarh 232 5 ( ( -LRB- cord-345222-otfnrarh 232 6 family family NN cord-345222-otfnrarh 232 7 Caliciviridae Caliciviridae NNP cord-345222-otfnrarh 232 8 , , , cord-345222-otfnrarh 232 9 genus genus NN cord-345222-otfnrarh 232 10 Sapovirus Sapovirus NNP cord-345222-otfnrarh 232 11 ) ) -RRB- cord-345222-otfnrarh 232 12 : : : cord-345222-otfnrarh 232 13 mainly mainly RB cord-345222-otfnrarh 232 14 infect infect VB cord-345222-otfnrarh 232 15 children child NNS cord-345222-otfnrarh 232 16 younger young JJR cord-345222-otfnrarh 232 17 than than IN cord-345222-otfnrarh 232 18 5 5 CD cord-345222-otfnrarh 232 19 years year NNS cord-345222-otfnrarh 232 20 of of IN cord-345222-otfnrarh 232 21 age age NN cord-345222-otfnrarh 232 22 . . . cord-345222-otfnrarh 233 1 59 59 CD cord-345222-otfnrarh 234 1 The the DT cord-345222-otfnrarh 234 2 illness illness NN cord-345222-otfnrarh 234 3 is be VBZ cord-345222-otfnrarh 234 4 milder mild JJR cord-345222-otfnrarh 234 5 than than IN cord-345222-otfnrarh 234 6 that that DT cord-345222-otfnrarh 234 7 caused cause VBN cord-345222-otfnrarh 234 8 by by IN cord-345222-otfnrarh 234 9 noroviruses noroviruse NNS cord-345222-otfnrarh 234 10 . . . cord-345222-otfnrarh 235 1 73 73 CD cord-345222-otfnrarh 235 2 Antibody antibody NN cord-345222-otfnrarh 235 3 prevalence prevalence NN cord-345222-otfnrarh 235 4 studies study NNS cord-345222-otfnrarh 235 5 show show VBP cord-345222-otfnrarh 235 6 that that IN cord-345222-otfnrarh 235 7 virtually virtually RB cord-345222-otfnrarh 235 8 all all DT cord-345222-otfnrarh 235 9 children child NNS cord-345222-otfnrarh 235 10 are be VBP cord-345222-otfnrarh 235 11 infected infect VBN cord-345222-otfnrarh 235 12 with with IN cord-345222-otfnrarh 235 13 sapoviruses sapoviruse NNS cord-345222-otfnrarh 235 14 by by IN cord-345222-otfnrarh 235 15 the the DT cord-345222-otfnrarh 235 16 time time NN cord-345222-otfnrarh 235 17 they -PRON- PRP cord-345222-otfnrarh 235 18 are be VBP cord-345222-otfnrarh 235 19 5 5 CD cord-345222-otfnrarh 235 20 years year NNS cord-345222-otfnrarh 235 21 of of IN cord-345222-otfnrarh 235 22 age age NN cord-345222-otfnrarh 235 23 , , , cord-345222-otfnrarh 235 24 indicating indicate VBG cord-345222-otfnrarh 235 25 that that IN cord-345222-otfnrarh 235 26 sapovirus sapovirus NNP cord-345222-otfnrarh 235 27 infection infection NN cord-345222-otfnrarh 235 28 is be VBZ cord-345222-otfnrarh 235 29 widespread widespread JJ cord-345222-otfnrarh 235 30 , , , cord-345222-otfnrarh 235 31 although although IN cord-345222-otfnrarh 235 32 the the DT cord-345222-otfnrarh 235 33 illness illness NN cord-345222-otfnrarh 235 34 most most RBS cord-345222-otfnrarh 235 35 likely likely RB cord-345222-otfnrarh 235 36 is be VBZ cord-345222-otfnrarh 235 37 sporadic sporadic JJ cord-345222-otfnrarh 235 38 with with IN cord-345222-otfnrarh 235 39 a a DT cord-345222-otfnrarh 235 40 high high JJ cord-345222-otfnrarh 235 41 rate rate NN cord-345222-otfnrarh 235 42 of of IN cord-345222-otfnrarh 235 43 asymptomatic asymptomatic JJ cord-345222-otfnrarh 235 44 infection infection NN cord-345222-otfnrarh 235 45 . . . cord-345222-otfnrarh 236 1 59 59 CD cord-345222-otfnrarh 236 2 , , , cord-345222-otfnrarh 236 3 74 74 CD cord-345222-otfnrarh 236 4 , , , cord-345222-otfnrarh 236 5 75 75 CD cord-345222-otfnrarh 236 6 Torque Torque NNP cord-345222-otfnrarh 236 7 teno teno NNP cord-345222-otfnrarh 236 8 midi midi NNP cord-345222-otfnrarh 236 9 virus virus NNP cord-345222-otfnrarh 236 10 / / SYM cord-345222-otfnrarh 236 11 small small JJ cord-345222-otfnrarh 236 12 anellovirus anellovirus NN cord-345222-otfnrarh 236 13 ( ( -LRB- cord-345222-otfnrarh 236 14 TTMDV TTMDV NNP cord-345222-otfnrarh 236 15 / / SYM cord-345222-otfnrarh 236 16 SAV SAV NNP cord-345222-otfnrarh 236 17 ) ) -RRB- cord-345222-otfnrarh 236 18 is be VBZ cord-345222-otfnrarh 236 19 a a DT cord-345222-otfnrarh 236 20 member member NN cord-345222-otfnrarh 236 21 of of IN cord-345222-otfnrarh 236 22 the the DT cord-345222-otfnrarh 236 23 family family NN cord-345222-otfnrarh 236 24 Anelloviridae Anelloviridae NNP cord-345222-otfnrarh 236 25 . . . cord-345222-otfnrarh 237 1 Although although IN cord-345222-otfnrarh 237 2 human human JJ cord-345222-otfnrarh 237 3 TTV TTV NNP cord-345222-otfnrarh 237 4 infection infection NN cord-345222-otfnrarh 237 5 is be VBZ cord-345222-otfnrarh 237 6 ubiquitous ubiquitous JJ cord-345222-otfnrarh 237 7 and and CC cord-345222-otfnrarh 237 8 several several JJ cord-345222-otfnrarh 237 9 infecting infect VBG cord-345222-otfnrarh 237 10 genogroups genogroup NNS cord-345222-otfnrarh 237 11 of of IN cord-345222-otfnrarh 237 12 the the DT cord-345222-otfnrarh 237 13 virus virus NN cord-345222-otfnrarh 237 14 have have VBP cord-345222-otfnrarh 237 15 been be VBN cord-345222-otfnrarh 237 16 identified identify VBN cord-345222-otfnrarh 237 17 , , , cord-345222-otfnrarh 237 18 to to IN cord-345222-otfnrarh 237 19 date date NN cord-345222-otfnrarh 237 20 there there EX cord-345222-otfnrarh 237 21 is be VBZ cord-345222-otfnrarh 237 22 no no DT cord-345222-otfnrarh 237 23 consistent consistent JJ cord-345222-otfnrarh 237 24 evidence evidence NN cord-345222-otfnrarh 237 25 of of IN cord-345222-otfnrarh 237 26 a a DT cord-345222-otfnrarh 237 27 link link NN cord-345222-otfnrarh 237 28 between between IN cord-345222-otfnrarh 237 29 TTV TTV NNP cord-345222-otfnrarh 237 30 infection infection NN cord-345222-otfnrarh 237 31 of of IN cord-345222-otfnrarh 237 32 humans human NNS cord-345222-otfnrarh 237 33 and and CC cord-345222-otfnrarh 237 34 specific specific JJ cord-345222-otfnrarh 237 35 disease disease NN cord-345222-otfnrarh 237 36 . . . cord-345222-otfnrarh 238 1 [ [ -LRB- cord-345222-otfnrarh 238 2 76 76 CD cord-345222-otfnrarh 238 3 ] ] -RRB- cord-345222-otfnrarh 238 4 [ [ -LRB- cord-345222-otfnrarh 238 5 77 77 CD cord-345222-otfnrarh 238 6 ] ] -RRB- cord-345222-otfnrarh 239 1 [ [ -LRB- cord-345222-otfnrarh 239 2 78 78 CD cord-345222-otfnrarh 239 3 ] ] -RRB- cord-345222-otfnrarh 239 4 [ [ -LRB- cord-345222-otfnrarh 239 5 79 79 CD cord-345222-otfnrarh 239 6 ] ] -RRB- cord-345222-otfnrarh 240 1 In in IN cord-345222-otfnrarh 240 2 a a DT cord-345222-otfnrarh 240 3 recent recent JJ cord-345222-otfnrarh 240 4 Hungarian hungarian JJ cord-345222-otfnrarh 240 5 study study NN cord-345222-otfnrarh 240 6 , , , cord-345222-otfnrarh 240 7 viral viral JJ cord-345222-otfnrarh 240 8 shedding shedding NN cord-345222-otfnrarh 240 9 , , , cord-345222-otfnrarh 240 10 molecular molecular JJ cord-345222-otfnrarh 240 11 epidemiology epidemiology NN cord-345222-otfnrarh 240 12 , , , cord-345222-otfnrarh 240 13 and and CC cord-345222-otfnrarh 240 14 genetic genetic JJ cord-345222-otfnrarh 240 15 diversity diversity NN cord-345222-otfnrarh 240 16 of of IN cord-345222-otfnrarh 240 17 TTMDV/ TTMDV/ NNP cord-345222-otfnrarh 240 18 SAV SAV NNP cord-345222-otfnrarh 240 19 were be VBD cord-345222-otfnrarh 240 20 studied study VBN cord-345222-otfnrarh 240 21 in in IN cord-345222-otfnrarh 240 22 human human JJ cord-345222-otfnrarh 240 23 body body NN cord-345222-otfnrarh 240 24 fluids fluid NNS cord-345222-otfnrarh 240 25 ( ( -LRB- cord-345222-otfnrarh 240 26 nasopharyngeal nasopharyngeal JJ cord-345222-otfnrarh 240 27 aspirates aspirate NNS cord-345222-otfnrarh 240 28 of of IN cord-345222-otfnrarh 240 29 children child NNS cord-345222-otfnrarh 240 30 with with IN cord-345222-otfnrarh 240 31 acute acute JJ cord-345222-otfnrarh 240 32 respiratory respiratory JJ cord-345222-otfnrarh 240 33 diseases disease NNS cord-345222-otfnrarh 240 34 and and CC cord-345222-otfnrarh 240 35 serum serum NN cord-345222-otfnrarh 240 36 , , , cord-345222-otfnrarh 240 37 stool stool NN cord-345222-otfnrarh 240 38 and and CC cord-345222-otfnrarh 240 39 urine urine NN cord-345222-otfnrarh 240 40 samples sample NNS cord-345222-otfnrarh 240 41 collected collect VBN cord-345222-otfnrarh 240 42 from from IN cord-345222-otfnrarh 240 43 eight eight CD cord-345222-otfnrarh 240 44 healthy healthy JJ cord-345222-otfnrarh 240 45 children child NNS cord-345222-otfnrarh 240 46 with with IN cord-345222-otfnrarh 240 47 previous previous JJ cord-345222-otfnrarh 240 48 TTMDV TTMDV NNP cord-345222-otfnrarh 240 49 / / SYM cord-345222-otfnrarh 240 50 SAV SAV NNP cord-345222-otfnrarh 240 51 infection infection NN cord-345222-otfnrarh 240 52 ) ) -RRB- cord-345222-otfnrarh 240 53 . . . cord-345222-otfnrarh 241 1 In in IN cord-345222-otfnrarh 241 2 this this DT cord-345222-otfnrarh 241 3 study study NN cord-345222-otfnrarh 241 4 , , , cord-345222-otfnrarh 241 5 shedding shed VBG cord-345222-otfnrarh 241 6 of of IN cord-345222-otfnrarh 241 7 TTMDV TTMDV NNP cord-345222-otfnrarh 241 8 / / SYM cord-345222-otfnrarh 241 9 SAV SAV NNP cord-345222-otfnrarh 241 10 and and CC cord-345222-otfnrarh 241 11 related related JJ cord-345222-otfnrarh 241 12 viruses virus NNS cord-345222-otfnrarh 241 13 was be VBD cord-345222-otfnrarh 241 14 detected detect VBN cord-345222-otfnrarh 241 15 in in IN cord-345222-otfnrarh 241 16 two two CD cord-345222-otfnrarh 241 17 other other JJ cord-345222-otfnrarh 241 18 human human JJ cord-345222-otfnrarh 241 19 body body NN cord-345222-otfnrarh 241 20 fluids fluid NNS cord-345222-otfnrarh 241 21 , , , cord-345222-otfnrarh 241 22 feces fece NNS cord-345222-otfnrarh 241 23 and and CC cord-345222-otfnrarh 241 24 urine urine NN cord-345222-otfnrarh 241 25 , , , cord-345222-otfnrarh 241 26 suggesting suggest VBG cord-345222-otfnrarh 241 27 the the DT cord-345222-otfnrarh 241 28 existence existence NN cord-345222-otfnrarh 241 29 of of IN cord-345222-otfnrarh 241 30 fecal fecal JJ cord-345222-otfnrarh 241 31 - - HYPH cord-345222-otfnrarh 241 32 oral oral JJ cord-345222-otfnrarh 241 33 / / SYM cord-345222-otfnrarh 241 34 urinary urinary JJ cord-345222-otfnrarh 241 35 - - HYPH cord-345222-otfnrarh 241 36 oral oral JJ cord-345222-otfnrarh 241 37 transmission transmission NN cord-345222-otfnrarh 241 38 routes route NNS cord-345222-otfnrarh 241 39 beyond beyond IN cord-345222-otfnrarh 241 40 the the DT cord-345222-otfnrarh 241 41 originally originally RB cord-345222-otfnrarh 241 42 presumed presume VBN cord-345222-otfnrarh 241 43 blood blood NN cord-345222-otfnrarh 241 44 - - HYPH cord-345222-otfnrarh 241 45 borne bear VBN cord-345222-otfnrarh 241 46 and and CC cord-345222-otfnrarh 241 47 later later RB cord-345222-otfnrarh 241 48 - - HYPH cord-345222-otfnrarh 241 49 suggested suggest VBN cord-345222-otfnrarh 241 50 respiratory respiratory JJ cord-345222-otfnrarh 241 51 route route NN cord-345222-otfnrarh 241 52 . . . cord-345222-otfnrarh 242 1 This this DT cord-345222-otfnrarh 242 2 finding finding NN cord-345222-otfnrarh 242 3 extends extend VBZ cord-345222-otfnrarh 242 4 the the DT cord-345222-otfnrarh 242 5 number number NN cord-345222-otfnrarh 242 6 of of IN cord-345222-otfnrarh 242 7 possible possible JJ cord-345222-otfnrarh 242 8 successful successful JJ cord-345222-otfnrarh 242 9 transmission transmission NN cord-345222-otfnrarh 242 10 routes route NNS cord-345222-otfnrarh 242 11 . . . cord-345222-otfnrarh 243 1 Fungal fungal JJ cord-345222-otfnrarh 243 2 enteritis enteritis NN cord-345222-otfnrarh 243 3 ( ( -LRB- cord-345222-otfnrarh 243 4 Table Table NNP cord-345222-otfnrarh 243 5 1C 1c NN cord-345222-otfnrarh 243 6 ) ) -RRB- cord-345222-otfnrarh 244 1 The the DT cord-345222-otfnrarh 244 2 pathogenic pathogenic JJ cord-345222-otfnrarh 244 3 role role NN cord-345222-otfnrarh 244 4 of of IN cord-345222-otfnrarh 244 5 Candida Candida NNP cord-345222-otfnrarh 244 6 in in IN cord-345222-otfnrarh 244 7 neonatal neonatal JJ cord-345222-otfnrarh 244 8 diarrhea diarrhea NN cord-345222-otfnrarh 244 9 is be VBZ cord-345222-otfnrarh 244 10 still still RB cord-345222-otfnrarh 244 11 difficult difficult JJ cord-345222-otfnrarh 244 12 to to TO cord-345222-otfnrarh 244 13 prove prove VB cord-345222-otfnrarh 244 14 . . . cord-345222-otfnrarh 245 1 Symptoms symptom NNS cord-345222-otfnrarh 245 2 ascribed ascribe VBN cord-345222-otfnrarh 245 3 to to IN cord-345222-otfnrarh 245 4 Candida Candida NNP cord-345222-otfnrarh 245 5 - - HYPH cord-345222-otfnrarh 245 6 associated associate VBN cord-345222-otfnrarh 245 7 diarrhea diarrhea NN cord-345222-otfnrarh 245 8 in in IN cord-345222-otfnrarh 245 9 the the DT cord-345222-otfnrarh 245 10 literature literature NN cord-345222-otfnrarh 245 11 include include VBP cord-345222-otfnrarh 245 12 prolonged prolong VBN cord-345222-otfnrarh 245 13 secretory secretory JJ cord-345222-otfnrarh 245 14 diarrhea diarrhea NN cord-345222-otfnrarh 245 15 with with IN cord-345222-otfnrarh 245 16 abdominal abdominal JJ cord-345222-otfnrarh 245 17 pain pain NN cord-345222-otfnrarh 245 18 and and CC cord-345222-otfnrarh 245 19 cramping cramping NN cord-345222-otfnrarh 245 20 but but CC cord-345222-otfnrarh 245 21 without without IN cord-345222-otfnrarh 245 22 blood blood NN cord-345222-otfnrarh 245 23 , , , cord-345222-otfnrarh 245 24 mucus mucus NN cord-345222-otfnrarh 245 25 , , , cord-345222-otfnrarh 245 26 fever fever NN cord-345222-otfnrarh 245 27 , , , cord-345222-otfnrarh 245 28 nausea nausea NN cord-345222-otfnrarh 245 29 , , , cord-345222-otfnrarh 245 30 or or CC cord-345222-otfnrarh 245 31 vomiting vomiting NN cord-345222-otfnrarh 245 32 . . . cord-345222-otfnrarh 246 1 80 80 CD cord-345222-otfnrarh 246 2 Disseminated disseminate VBN cord-345222-otfnrarh 246 3 Candida Candida NNP cord-345222-otfnrarh 246 4 infection infection NN cord-345222-otfnrarh 246 5 can can MD cord-345222-otfnrarh 246 6 cause cause VB cord-345222-otfnrarh 246 7 intestinal intestinal JJ cord-345222-otfnrarh 246 8 symptoms symptom NNS cord-345222-otfnrarh 246 9 similar similar JJ cord-345222-otfnrarh 246 10 to to IN cord-345222-otfnrarh 246 11 necrotizing necrotize VBG cord-345222-otfnrarh 246 12 enterocolitis enterocolitis NN cord-345222-otfnrarh 246 13 , , , cord-345222-otfnrarh 246 14 especially especially RB cord-345222-otfnrarh 246 15 in in IN cord-345222-otfnrarh 246 16 premature premature JJ cord-345222-otfnrarh 246 17 infants infant NNS cord-345222-otfnrarh 246 18 and and CC cord-345222-otfnrarh 246 19 in in IN cord-345222-otfnrarh 246 20 infants infant NNS cord-345222-otfnrarh 246 21 treated treat VBN cord-345222-otfnrarh 246 22 with with IN cord-345222-otfnrarh 246 23 antibiotics antibiotic NNS cord-345222-otfnrarh 246 24 ( ( -LRB- cord-345222-otfnrarh 246 25 especially especially RB cord-345222-otfnrarh 246 26 third third JJ cord-345222-otfnrarh 246 27 - - HYPH cord-345222-otfnrarh 246 28 generation generation NN cord-345222-otfnrarh 246 29 cephalosporins cephalosporin NNS cord-345222-otfnrarh 246 30 ) ) -RRB- cord-345222-otfnrarh 246 31 and and CC cord-345222-otfnrarh 246 32 with with IN cord-345222-otfnrarh 246 33 central central JJ cord-345222-otfnrarh 246 34 venous venous JJ cord-345222-otfnrarh 246 35 catheters catheter NNS cord-345222-otfnrarh 246 36 or or CC cord-345222-otfnrarh 246 37 in in IN cord-345222-otfnrarh 246 38 surgical surgical JJ cord-345222-otfnrarh 246 39 patients patient NNS cord-345222-otfnrarh 246 40 . . . cord-345222-otfnrarh 247 1 81 81 CD cord-345222-otfnrarh 247 2 , , , cord-345222-otfnrarh 247 3 82 82 CD cord-345222-otfnrarh 247 4 Candida Candida NNP cord-345222-otfnrarh 247 5 infections infection NNS cord-345222-otfnrarh 247 6 frequently frequently RB cord-345222-otfnrarh 247 7 develop develop VBP cord-345222-otfnrarh 247 8 into into IN cord-345222-otfnrarh 247 9 systemic systemic JJ cord-345222-otfnrarh 247 10 forms form NNS cord-345222-otfnrarh 247 11 , , , cord-345222-otfnrarh 247 12 and and CC cord-345222-otfnrarh 247 13 are be VBP cord-345222-otfnrarh 247 14 a a DT cord-345222-otfnrarh 247 15 major major JJ cord-345222-otfnrarh 247 16 cause cause NN cord-345222-otfnrarh 247 17 of of IN cord-345222-otfnrarh 247 18 morbidity morbidity NN cord-345222-otfnrarh 247 19 and and CC cord-345222-otfnrarh 247 20 mortality mortality NN cord-345222-otfnrarh 247 21 in in IN cord-345222-otfnrarh 247 22 neonatal neonatal JJ cord-345222-otfnrarh 247 23 intensive intensive JJ cord-345222-otfnrarh 247 24 care care NN cord-345222-otfnrarh 247 25 units unit NNS cord-345222-otfnrarh 247 26 . . . cord-345222-otfnrarh 248 1 83 83 CD cord-345222-otfnrarh 249 1 The the DT cord-345222-otfnrarh 249 2 incidence incidence NN cord-345222-otfnrarh 249 3 of of IN cord-345222-otfnrarh 249 4 candidemia candidemia NN cord-345222-otfnrarh 249 5 in in IN cord-345222-otfnrarh 249 6 the the DT cord-345222-otfnrarh 249 7 neonatal neonatal JJ cord-345222-otfnrarh 249 8 intensive intensive JJ cord-345222-otfnrarh 249 9 care care NN cord-345222-otfnrarh 249 10 unit unit NN cord-345222-otfnrarh 249 11 is be VBZ cord-345222-otfnrarh 249 12 steadily steadily RB cord-345222-otfnrarh 249 13 increasing increase VBG cord-345222-otfnrarh 249 14 , , , cord-345222-otfnrarh 249 15 with with IN cord-345222-otfnrarh 249 16 an an DT cord-345222-otfnrarh 249 17 estimated estimate VBN cord-345222-otfnrarh 249 18 incidence incidence NN cord-345222-otfnrarh 249 19 of of IN cord-345222-otfnrarh 249 20 1%-2 1%-2 CD cord-345222-otfnrarh 249 21 % % NN cord-345222-otfnrarh 249 22 in in IN cord-345222-otfnrarh 249 23 very very RB cord-345222-otfnrarh 249 24 low low JJ cord-345222-otfnrarh 249 25 - - HYPH cord-345222-otfnrarh 249 26 birth birth NN cord-345222-otfnrarh 249 27 - - HYPH cord-345222-otfnrarh 249 28 weight weight NN cord-345222-otfnrarh 249 29 infants infant NNS cord-345222-otfnrarh 249 30 and and CC cord-345222-otfnrarh 249 31 of of IN cord-345222-otfnrarh 249 32 2%-23 2%-23 CD cord-345222-otfnrarh 249 33 % % NN cord-345222-otfnrarh 249 34 in in IN cord-345222-otfnrarh 249 35 extremely extremely RB cord-345222-otfnrarh 249 36 low low JJ cord-345222-otfnrarh 249 37 - - HYPH cord-345222-otfnrarh 249 38 birth birth NN cord-345222-otfnrarh 249 39 - - HYPH cord-345222-otfnrarh 249 40 weight weight NN cord-345222-otfnrarh 249 41 infants infant NNS cord-345222-otfnrarh 249 42 . . . cord-345222-otfnrarh 250 1 84 84 CD cord-345222-otfnrarh 250 2 Infection infection NN cord-345222-otfnrarh 250 3 - - HYPH cord-345222-otfnrarh 250 4 associated associate VBN cord-345222-otfnrarh 250 5 mortality mortality NN cord-345222-otfnrarh 250 6 following follow VBG cord-345222-otfnrarh 250 7 Candida Candida NNP cord-345222-otfnrarh 250 8 bloodstream bloodstream NN cord-345222-otfnrarh 250 9 infections infection NNS cord-345222-otfnrarh 250 10 is be VBZ cord-345222-otfnrarh 250 11 as as RB cord-345222-otfnrarh 250 12 high high JJ cord-345222-otfnrarh 250 13 as as IN cord-345222-otfnrarh 250 14 40 40 CD cord-345222-otfnrarh 250 15 % % NN cord-345222-otfnrarh 250 16 ( ( -LRB- cord-345222-otfnrarh 250 17 very very RB cord-345222-otfnrarh 250 18 low low JJ cord-345222-otfnrarh 250 19 birth birth NN cord-345222-otfnrarh 250 20 weight weight NN cord-345222-otfnrarh 250 21 2%-30 2%-30 CD cord-345222-otfnrarh 250 22 % % NN cord-345222-otfnrarh 250 23 , , , cord-345222-otfnrarh 250 24 extremely extremely RB cord-345222-otfnrarh 250 25 low low JJ cord-345222-otfnrarh 250 26 birth birth NN cord-345222-otfnrarh 250 27 weight weight NN cord-345222-otfnrarh 250 28 12%-50 12%-50 CD cord-345222-otfnrarh 250 29 % % NN cord-345222-otfnrarh 250 30 ) ) -RRB- cord-345222-otfnrarh 250 31 , , , cord-345222-otfnrarh 250 32 and and CC cord-345222-otfnrarh 250 33 neurodevelopmental neurodevelopmental JJ cord-345222-otfnrarh 250 34 impairment impairment NN cord-345222-otfnrarh 250 35 is be VBZ cord-345222-otfnrarh 250 36 common common JJ cord-345222-otfnrarh 250 37 among among IN cord-345222-otfnrarh 250 38 survivors survivor NNS cord-345222-otfnrarh 250 39 ( ( -LRB- cord-345222-otfnrarh 250 40 extremely extremely RB cord-345222-otfnrarh 250 41 low low JJ cord-345222-otfnrarh 250 42 birth birth NN cord-345222-otfnrarh 250 43 weight weight NN cord-345222-otfnrarh 250 44 57 57 CD cord-345222-otfnrarh 250 45 % % NN cord-345222-otfnrarh 250 46 ) ) -RRB- cord-345222-otfnrarh 250 47 . . . cord-345222-otfnrarh 251 1 [ [ -LRB- cord-345222-otfnrarh 251 2 84 84 CD cord-345222-otfnrarh 251 3 ] ] -RRB- cord-345222-otfnrarh 251 4 [ [ -LRB- cord-345222-otfnrarh 251 5 85 85 CD cord-345222-otfnrarh 251 6 ] ] -RRB- cord-345222-otfnrarh 251 7 [ [ -LRB- cord-345222-otfnrarh 251 8 86 86 CD cord-345222-otfnrarh 251 9 ] ] -RRB- cord-345222-otfnrarh 251 10 [ [ -LRB- cord-345222-otfnrarh 251 11 87 87 CD cord-345222-otfnrarh 251 12 ] ] -RRB- cord-345222-otfnrarh 251 13 [ [ -LRB- cord-345222-otfnrarh 251 14 88 88 CD cord-345222-otfnrarh 251 15 ] ] -RRB- cord-345222-otfnrarh 252 1 Because because IN cord-345222-otfnrarh 252 2 invasive invasive JJ cord-345222-otfnrarh 252 3 fungal fungal JJ cord-345222-otfnrarh 252 4 infections infection NNS cord-345222-otfnrarh 252 5 are be VBP cord-345222-otfnrarh 252 6 common common JJ cord-345222-otfnrarh 252 7 and and CC cord-345222-otfnrarh 252 8 extremely extremely RB cord-345222-otfnrarh 252 9 difficult difficult JJ cord-345222-otfnrarh 252 10 to to TO cord-345222-otfnrarh 252 11 diagnose diagnose VB cord-345222-otfnrarh 252 12 , , , cord-345222-otfnrarh 252 13 prevention prevention NN cord-345222-otfnrarh 252 14 ( ( -LRB- cord-345222-otfnrarh 252 15 decrease decrease NN cord-345222-otfnrarh 252 16 of of IN cord-345222-otfnrarh 252 17 risk risk NN cord-345222-otfnrarh 252 18 factors factor NNS cord-345222-otfnrarh 252 19 that that WDT cord-345222-otfnrarh 252 20 contribute contribute VBP cord-345222-otfnrarh 252 21 to to IN cord-345222-otfnrarh 252 22 increased increase VBN cord-345222-otfnrarh 252 23 colonization colonization NN cord-345222-otfnrarh 252 24 and and CC cord-345222-otfnrarh 252 25 concentration concentration NN cord-345222-otfnrarh 252 26 of of IN cord-345222-otfnrarh 252 27 fungal fungal JJ cord-345222-otfnrarh 252 28 organisms organism NNS cord-345222-otfnrarh 252 29 like like IN cord-345222-otfnrarh 252 30 maternal maternal JJ cord-345222-otfnrarh 252 31 vertical vertical JJ cord-345222-otfnrarh 252 32 transmission transmission NN cord-345222-otfnrarh 252 33 or or CC cord-345222-otfnrarh 252 34 nosocomial nosocomial JJ cord-345222-otfnrarh 252 35 acquisition acquisition NN cord-345222-otfnrarh 252 36 ) ) -RRB- cord-345222-otfnrarh 252 37 and and CC cord-345222-otfnrarh 252 38 antifungal antifungal JJ cord-345222-otfnrarh 252 39 prophylaxis prophylaxis NN cord-345222-otfnrarh 252 40 should should MD cord-345222-otfnrarh 252 41 be be VB cord-345222-otfnrarh 252 42 considered consider VBN cord-345222-otfnrarh 252 43 . . . cord-345222-otfnrarh 253 1 89 89 CD cord-345222-otfnrarh 253 2 Parasitic parasitic JJ cord-345222-otfnrarh 253 3 enteritis enteritis NN cord-345222-otfnrarh 254 1 -protozoan -protozoan : cord-345222-otfnrarh 255 1 ( ( -LRB- cord-345222-otfnrarh 255 2 Table table NN cord-345222-otfnrarh 255 3 1C 1c NN cord-345222-otfnrarh 255 4 ) ) -RRB- cord-345222-otfnrarh 256 1 Some some DT cord-345222-otfnrarh 256 2 waterborne waterborne JJ cord-345222-otfnrarh 256 3 protozoan protozoan NN cord-345222-otfnrarh 256 4 parasites parasite NNS cord-345222-otfnrarh 256 5 induce induce VBP cord-345222-otfnrarh 256 6 enteritis enteritis NN cord-345222-otfnrarh 256 7 through through IN cord-345222-otfnrarh 256 8 their -PRON- PRP$ cord-345222-otfnrarh 256 9 membrane membrane NN cord-345222-otfnrarh 256 10 - - HYPH cord-345222-otfnrarh 256 11 associated associate VBN cord-345222-otfnrarh 256 12 functional functional JJ cord-345222-otfnrarh 256 13 structures structure NNS cord-345222-otfnrarh 256 14 and and CC cord-345222-otfnrarh 256 15 virulence virulence NN cord-345222-otfnrarh 256 16 factors factor NNS cord-345222-otfnrarh 256 17 that that WDT cord-345222-otfnrarh 256 18 alter alter VBP cord-345222-otfnrarh 256 19 host host NN cord-345222-otfnrarh 256 20 cellular cellular JJ cord-345222-otfnrarh 256 21 molecules molecule NNS cord-345222-otfnrarh 256 22 and and CC cord-345222-otfnrarh 256 23 submit submit VB cord-345222-otfnrarh 256 24 your -PRON- PRP$ cord-345222-otfnrarh 256 25 manuscript manuscript NN cord-345222-otfnrarh 256 26 | | POS cord-345222-otfnrarh 256 27 www.dovepress.com www.dovepress.com ADD cord-345222-otfnrarh 257 1 Dovepress Dovepress NNP cord-345222-otfnrarh 257 2 Dovepress Dovepress NNP cord-345222-otfnrarh 257 3 signaling signal VBG cord-345222-otfnrarh 257 4 pathways pathway NNS cord-345222-otfnrarh 257 5 , , , cord-345222-otfnrarh 257 6 leading lead VBG cord-345222-otfnrarh 257 7 to to IN cord-345222-otfnrarh 257 8 structural structural JJ cord-345222-otfnrarh 257 9 and and CC cord-345222-otfnrarh 257 10 functional functional JJ cord-345222-otfnrarh 257 11 lesions lesion NNS cord-345222-otfnrarh 257 12 in in IN cord-345222-otfnrarh 257 13 the the DT cord-345222-otfnrarh 257 14 intestinal intestinal JJ cord-345222-otfnrarh 257 15 barrier barrier NN cord-345222-otfnrarh 257 16 . . . cord-345222-otfnrarh 258 1 90 90 CD cord-345222-otfnrarh 258 2 Cryptosporidium cryptosporidium NN cord-345222-otfnrarh 258 3 parvum parvum NN cord-345222-otfnrarh 258 4 has have VBZ cord-345222-otfnrarh 258 5 a a DT cord-345222-otfnrarh 258 6 high high JJ cord-345222-otfnrarh 258 7 infectivity infectivity NN cord-345222-otfnrarh 258 8 with with IN cord-345222-otfnrarh 258 9 significant significant JJ cord-345222-otfnrarh 258 10 enteric enteric JJ cord-345222-otfnrarh 258 11 disease disease NN cord-345222-otfnrarh 258 12 : : : cord-345222-otfnrarh 258 13 rarely rarely RB cord-345222-otfnrarh 258 14 is be VBZ cord-345222-otfnrarh 258 15 asymptomatic asymptomatic JJ cord-345222-otfnrarh 258 16 . . . cord-345222-otfnrarh 259 1 There there EX cord-345222-otfnrarh 259 2 have have VBP cord-345222-otfnrarh 259 3 been be VBN cord-345222-otfnrarh 259 4 reported report VBN cord-345222-otfnrarh 259 5 cases case NNS cord-345222-otfnrarh 259 6 of of IN cord-345222-otfnrarh 259 7 infection infection NN cord-345222-otfnrarh 259 8 in in IN cord-345222-otfnrarh 259 9 the the DT cord-345222-otfnrarh 259 10 first first JJ cord-345222-otfnrarh 259 11 month month NN cord-345222-otfnrarh 259 12 of of IN cord-345222-otfnrarh 259 13 life life NN cord-345222-otfnrarh 259 14 ; ; : cord-345222-otfnrarh 259 15 the the DT cord-345222-otfnrarh 259 16 passage passage NN cord-345222-otfnrarh 259 17 of of IN cord-345222-otfnrarh 259 18 the the DT cord-345222-otfnrarh 259 19 maternal maternal JJ cord-345222-otfnrarh 259 20 antibodies antibody NNS cord-345222-otfnrarh 259 21 and and CC cord-345222-otfnrarh 259 22 breastfeeding breastfeeding NN cord-345222-otfnrarh 259 23 are be VBP cord-345222-otfnrarh 259 24 a a DT cord-345222-otfnrarh 259 25 protective protective JJ cord-345222-otfnrarh 259 26 factor factor NN cord-345222-otfnrarh 259 27 against against IN cord-345222-otfnrarh 259 28 infection infection NN cord-345222-otfnrarh 259 29 . . . cord-345222-otfnrarh 260 1 91 91 CD cord-345222-otfnrarh 260 2 Giardiasis giardiasis NN cord-345222-otfnrarh 260 3 is be VBZ cord-345222-otfnrarh 260 4 one one CD cord-345222-otfnrarh 260 5 of of IN cord-345222-otfnrarh 260 6 the the DT cord-345222-otfnrarh 260 7 intestinal intestinal JJ cord-345222-otfnrarh 260 8 protozoa protozoan NNS cord-345222-otfnrarh 260 9 that that WDT cord-345222-otfnrarh 260 10 cause cause VBP cord-345222-otfnrarh 260 11 public public JJ cord-345222-otfnrarh 260 12 health health NN cord-345222-otfnrarh 260 13 problems problem NNS cord-345222-otfnrarh 260 14 in in IN cord-345222-otfnrarh 260 15 most most JJS cord-345222-otfnrarh 260 16 resource resource NN cord-345222-otfnrarh 260 17 - - HYPH cord-345222-otfnrarh 260 18 constrained constrain VBN cord-345222-otfnrarh 260 19 nations nation NNS cord-345222-otfnrarh 260 20 , , , cord-345222-otfnrarh 260 21 as as RB cord-345222-otfnrarh 260 22 well well RB cord-345222-otfnrarh 260 23 as as IN cord-345222-otfnrarh 260 24 some some DT cord-345222-otfnrarh 260 25 resource resource NN cord-345222-otfnrarh 260 26 - - HYPH cord-345222-otfnrarh 260 27 rich rich JJ cord-345222-otfnrarh 260 28 countries country NNS cord-345222-otfnrarh 260 29 . . . cord-345222-otfnrarh 261 1 Many many JJ cord-345222-otfnrarh 261 2 infected infected JJ cord-345222-otfnrarh 261 3 persons person NNS cord-345222-otfnrarh 261 4 can can MD cord-345222-otfnrarh 261 5 be be VB cord-345222-otfnrarh 261 6 asymptomatic asymptomatic JJ cord-345222-otfnrarh 261 7 , , , cord-345222-otfnrarh 261 8 leading lead VBG cord-345222-otfnrarh 261 9 to to IN cord-345222-otfnrarh 261 10 difficulties difficulty NNS cord-345222-otfnrarh 261 11 in in IN cord-345222-otfnrarh 261 12 the the DT cord-345222-otfnrarh 261 13 eradication eradication NN cord-345222-otfnrarh 261 14 and and CC cord-345222-otfnrarh 261 15 control control NN cord-345222-otfnrarh 261 16 of of IN cord-345222-otfnrarh 261 17 this this DT cord-345222-otfnrarh 261 18 parasite parasite NN cord-345222-otfnrarh 261 19 due due IN cord-345222-otfnrarh 261 20 to to IN cord-345222-otfnrarh 261 21 the the DT cord-345222-otfnrarh 261 22 number number NN cord-345222-otfnrarh 261 23 of of IN cord-345222-otfnrarh 261 24 potential potential JJ cord-345222-otfnrarh 261 25 carriers carrier NNS cord-345222-otfnrarh 261 26 , , , cord-345222-otfnrarh 261 27 such such JJ cord-345222-otfnrarh 261 28 as as IN cord-345222-otfnrarh 261 29 school school NN cord-345222-otfnrarh 261 30 children child NNS cord-345222-otfnrarh 261 31 . . . cord-345222-otfnrarh 262 1 Giardia Giardia NNP cord-345222-otfnrarh 262 2 lamblia lamblia NNP cord-345222-otfnrarh 262 3 is be VBZ cord-345222-otfnrarh 262 4 observed observe VBN cord-345222-otfnrarh 262 5 almost almost RB cord-345222-otfnrarh 262 6 three three CD cord-345222-otfnrarh 262 7 times time NNS cord-345222-otfnrarh 262 8 more more RBR cord-345222-otfnrarh 262 9 in in IN cord-345222-otfnrarh 262 10 asymptomatic asymptomatic JJ cord-345222-otfnrarh 262 11 children child NNS cord-345222-otfnrarh 262 12 than than IN cord-345222-otfnrarh 262 13 in in IN cord-345222-otfnrarh 262 14 symptomatic symptomatic JJ cord-345222-otfnrarh 262 15 children child NNS cord-345222-otfnrarh 262 16 . . . cord-345222-otfnrarh 263 1 The the DT cord-345222-otfnrarh 263 2 first first JJ cord-345222-otfnrarh 263 3 signs sign NNS cord-345222-otfnrarh 263 4 of of IN cord-345222-otfnrarh 263 5 acute acute JJ cord-345222-otfnrarh 263 6 giardiasis giardiasis NN cord-345222-otfnrarh 263 7 include include VBP cord-345222-otfnrarh 263 8 nausea nausea NN cord-345222-otfnrarh 263 9 , , , cord-345222-otfnrarh 263 10 loss loss NN cord-345222-otfnrarh 263 11 of of IN cord-345222-otfnrarh 263 12 appetite appetite NN cord-345222-otfnrarh 263 13 and and CC cord-345222-otfnrarh 263 14 an an DT cord-345222-otfnrarh 263 15 upper upper JJ cord-345222-otfnrarh 263 16 gastro gastro JJ cord-345222-otfnrarh 263 17 - - JJ cord-345222-otfnrarh 263 18 intestinal intestinal JJ cord-345222-otfnrarh 263 19 uneasiness uneasiness NN cord-345222-otfnrarh 263 20 , , , cord-345222-otfnrarh 263 21 followed follow VBD cord-345222-otfnrarh 263 22 or or CC cord-345222-otfnrarh 263 23 accompanied accompany VBN cord-345222-otfnrarh 263 24 by by IN cord-345222-otfnrarh 263 25 a a DT cord-345222-otfnrarh 263 26 sudden sudden JJ cord-345222-otfnrarh 263 27 onset onset NN cord-345222-otfnrarh 263 28 of of IN cord-345222-otfnrarh 263 29 explosive explosive JJ cord-345222-otfnrarh 263 30 , , , cord-345222-otfnrarh 263 31 watery watery JJ cord-345222-otfnrarh 263 32 , , , cord-345222-otfnrarh 263 33 foul foul RB cord-345222-otfnrarh 263 34 - - HYPH cord-345222-otfnrarh 263 35 smelling smell VBG cord-345222-otfnrarh 263 36 diarrhea diarrhea NN cord-345222-otfnrarh 263 37 . . . cord-345222-otfnrarh 264 1 Stools stool NNS cord-345222-otfnrarh 264 2 associated associate VBN cord-345222-otfnrarh 264 3 with with IN cord-345222-otfnrarh 264 4 Giardia Giardia NNP cord-345222-otfnrarh 264 5 infection infection NN cord-345222-otfnrarh 264 6 are be VBP cord-345222-otfnrarh 264 7 generally generally RB cord-345222-otfnrarh 264 8 described describe VBN cord-345222-otfnrarh 264 9 as as IN cord-345222-otfnrarh 264 10 loose loose JJ cord-345222-otfnrarh 264 11 , , , cord-345222-otfnrarh 264 12 bulky bulky JJ cord-345222-otfnrarh 264 13 , , , cord-345222-otfnrarh 264 14 frothy frothy JJ cord-345222-otfnrarh 264 15 and/or and/or CC cord-345222-otfnrarh 264 16 greasy greasy JJ cord-345222-otfnrarh 264 17 with with IN cord-345222-otfnrarh 264 18 the the DT cord-345222-otfnrarh 264 19 absence absence NN cord-345222-otfnrarh 264 20 of of IN cord-345222-otfnrarh 264 21 blood blood NN cord-345222-otfnrarh 264 22 or or CC cord-345222-otfnrarh 264 23 mucus mucus NN cord-345222-otfnrarh 264 24 , , , cord-345222-otfnrarh 264 25 which which WDT cord-345222-otfnrarh 264 26 may may MD cord-345222-otfnrarh 264 27 help help VB cord-345222-otfnrarh 264 28 distinguish distinguish VB cord-345222-otfnrarh 264 29 giardiasis giardiasis NN cord-345222-otfnrarh 264 30 from from IN cord-345222-otfnrarh 264 31 other other JJ cord-345222-otfnrarh 264 32 acute acute JJ cord-345222-otfnrarh 264 33 diarrheas diarrhea NNS cord-345222-otfnrarh 264 34 . . . cord-345222-otfnrarh 265 1 Other other JJ cord-345222-otfnrarh 265 2 gastro gastro JJ cord-345222-otfnrarh 265 3 - - JJ cord-345222-otfnrarh 265 4 intestinal intestinal JJ cord-345222-otfnrarh 265 5 disturbances disturbance NNS cord-345222-otfnrarh 265 6 may may MD cord-345222-otfnrarh 265 7 include include VB cord-345222-otfnrarh 265 8 : : : cord-345222-otfnrarh 265 9 flatulence flatulence NN cord-345222-otfnrarh 265 10 , , , cord-345222-otfnrarh 265 11 bloating bloating NN cord-345222-otfnrarh 265 12 , , , cord-345222-otfnrarh 265 13 anorexia anorexia NN cord-345222-otfnrarh 265 14 , , , cord-345222-otfnrarh 265 15 cramps cramp NNS cord-345222-otfnrarh 265 16 . . . cord-345222-otfnrarh 266 1 The the DT cord-345222-otfnrarh 266 2 acute acute JJ cord-345222-otfnrarh 266 3 stage stage NN cord-345222-otfnrarh 266 4 usually usually RB cord-345222-otfnrarh 266 5 resolves resolve VBZ cord-345222-otfnrarh 266 6 spontaneously spontaneously RB cord-345222-otfnrarh 266 7 in in IN cord-345222-otfnrarh 266 8 a a DT cord-345222-otfnrarh 266 9 few few JJ cord-345222-otfnrarh 266 10 days day NNS cord-345222-otfnrarh 266 11 . . . cord-345222-otfnrarh 267 1 Occasionally occasionally RB cord-345222-otfnrarh 267 2 an an DT cord-345222-otfnrarh 267 3 acute acute JJ cord-345222-otfnrarh 267 4 infection infection NN cord-345222-otfnrarh 267 5 will will MD cord-345222-otfnrarh 267 6 persist persist VB cord-345222-otfnrarh 267 7 and and CC cord-345222-otfnrarh 267 8 lead lead VB cord-345222-otfnrarh 267 9 to to IN cord-345222-otfnrarh 267 10 malabsorption malabsorption NN cord-345222-otfnrarh 267 11 , , , cord-345222-otfnrarh 267 12 steatorrhea steatorrhea NN cord-345222-otfnrarh 267 13 , , , cord-345222-otfnrarh 267 14 loss loss NN cord-345222-otfnrarh 267 15 of of IN cord-345222-otfnrarh 267 16 strength strength NN cord-345222-otfnrarh 267 17 and and CC cord-345222-otfnrarh 267 18 weight weight NN cord-345222-otfnrarh 267 19 loss loss NN cord-345222-otfnrarh 267 20 . . . cord-345222-otfnrarh 268 1 It -PRON- PRP cord-345222-otfnrarh 268 2 has have VBZ cord-345222-otfnrarh 268 3 been be VBN cord-345222-otfnrarh 268 4 estimated estimate VBN cord-345222-otfnrarh 268 5 that that IN cord-345222-otfnrarh 268 6 about about RB cord-345222-otfnrarh 268 7 200 200 CD cord-345222-otfnrarh 268 8 million million CD cord-345222-otfnrarh 268 9 people people NNS cord-345222-otfnrarh 268 10 are be VBP cord-345222-otfnrarh 268 11 infected infect VBN cord-345222-otfnrarh 268 12 each each DT cord-345222-otfnrarh 268 13 year year NN cord-345222-otfnrarh 268 14 in in IN cord-345222-otfnrarh 268 15 Africa Africa NNP cord-345222-otfnrarh 268 16 , , , cord-345222-otfnrarh 268 17 Asia Asia NNP cord-345222-otfnrarh 268 18 and and CC cord-345222-otfnrarh 268 19 Latin Latin NNP cord-345222-otfnrarh 268 20 America America NNP cord-345222-otfnrarh 268 21 . . . cord-345222-otfnrarh 269 1 In in IN cord-345222-otfnrarh 269 2 the the DT cord-345222-otfnrarh 269 3 resource resource NN cord-345222-otfnrarh 269 4 - - HYPH cord-345222-otfnrarh 269 5 rich rich JJ cord-345222-otfnrarh 269 6 countries country NNS cord-345222-otfnrarh 269 7 the the DT cord-345222-otfnrarh 269 8 prevalence prevalence NN cord-345222-otfnrarh 269 9 rate rate NN cord-345222-otfnrarh 269 10 of of IN cord-345222-otfnrarh 269 11 giardiasis giardiasis NN cord-345222-otfnrarh 269 12 is be VBZ cord-345222-otfnrarh 269 13 2 2 CD cord-345222-otfnrarh 269 14 - - SYM cord-345222-otfnrarh 269 15 5 5 CD cord-345222-otfnrarh 269 16 % % NN cord-345222-otfnrarh 269 17 . . . cord-345222-otfnrarh 270 1 However however RB cord-345222-otfnrarh 270 2 , , , cord-345222-otfnrarh 270 3 in in IN cord-345222-otfnrarh 270 4 resorce resorce NN cord-345222-otfnrarh 270 5 - - HYPH cord-345222-otfnrarh 270 6 constrained constrain VBN cord-345222-otfnrarh 270 7 countries country NNS cord-345222-otfnrarh 270 8 , , , cord-345222-otfnrarh 270 9 Giardia Giardia NNP cord-345222-otfnrarh 270 10 lamblia lamblia NNP cord-345222-otfnrarh 270 11 infects infect VBZ cord-345222-otfnrarh 270 12 children child NNS cord-345222-otfnrarh 270 13 early early RB cord-345222-otfnrarh 270 14 in in IN cord-345222-otfnrarh 270 15 life life NN cord-345222-otfnrarh 270 16 thus thus RB cord-345222-otfnrarh 270 17 a a DT cord-345222-otfnrarh 270 18 prevalence prevalence NN cord-345222-otfnrarh 270 19 rate rate NN cord-345222-otfnrarh 270 20 of of IN cord-345222-otfnrarh 270 21 15 15 CD cord-345222-otfnrarh 270 22 - - SYM cord-345222-otfnrarh 270 23 20 20 CD cord-345222-otfnrarh 270 24 % % NN cord-345222-otfnrarh 270 25 in in IN cord-345222-otfnrarh 270 26 children child NNS cord-345222-otfnrarh 270 27 younger young JJR cord-345222-otfnrarh 270 28 than than IN cord-345222-otfnrarh 270 29 10 10 CD cord-345222-otfnrarh 270 30 years year NNS cord-345222-otfnrarh 270 31 is be VBZ cord-345222-otfnrarh 270 32 common common JJ cord-345222-otfnrarh 270 33 . . . cord-345222-otfnrarh 271 1 Children child NNS cord-345222-otfnrarh 271 2 who who WP cord-345222-otfnrarh 271 3 are be VBP cord-345222-otfnrarh 271 4 malnourished malnourish VBN cord-345222-otfnrarh 271 5 are be VBP cord-345222-otfnrarh 271 6 more more RBR cord-345222-otfnrarh 271 7 frequently frequently RB cord-345222-otfnrarh 271 8 infected infect VBN cord-345222-otfnrarh 271 9 . . . cord-345222-otfnrarh 272 1 92 92 CD cord-345222-otfnrarh 272 2 Cryptosporidium cryptosporidium NN cord-345222-otfnrarh 272 3 and and CC cord-345222-otfnrarh 272 4 Giardia Giardia NNP cord-345222-otfnrarh 272 5 most most RBS cord-345222-otfnrarh 272 6 often often RB cord-345222-otfnrarh 272 7 cause cause VBP cord-345222-otfnrarh 272 8 diarrhea diarrhea NN cord-345222-otfnrarh 272 9 in in IN cord-345222-otfnrarh 272 10 immunocompromised immunocompromised JJ cord-345222-otfnrarh 272 11 children child NNS cord-345222-otfnrarh 272 12 or or CC cord-345222-otfnrarh 272 13 in in IN cord-345222-otfnrarh 272 14 children child NNS cord-345222-otfnrarh 272 15 from from IN cord-345222-otfnrarh 272 16 resource resource NN cord-345222-otfnrarh 272 17 - - HYPH cord-345222-otfnrarh 272 18 constrained constrain VBN cord-345222-otfnrarh 272 19 nations nation NNS cord-345222-otfnrarh 272 20 , , , cord-345222-otfnrarh 272 21 and and CC cord-345222-otfnrarh 272 22 diarrhea diarrhea NN cord-345222-otfnrarh 272 23 tends tend VBZ cord-345222-otfnrarh 272 24 to to TO cord-345222-otfnrarh 272 25 be be VB cord-345222-otfnrarh 272 26 chronic chronic JJ cord-345222-otfnrarh 272 27 in in IN cord-345222-otfnrarh 272 28 both both DT cord-345222-otfnrarh 272 29 settings setting NNS cord-345222-otfnrarh 272 30 . . . cord-345222-otfnrarh 273 1 60 60 CD cord-345222-otfnrarh 273 2 , , , cord-345222-otfnrarh 273 3 92 92 CD cord-345222-otfnrarh 273 4 , , , cord-345222-otfnrarh 273 5 93 93 CD cord-345222-otfnrarh 274 1 Although although IN cord-345222-otfnrarh 274 2 E E NNP cord-345222-otfnrarh 274 3 histolytica histolytica NNP cord-345222-otfnrarh 274 4 generally generally RB cord-345222-otfnrarh 274 5 causes cause VBZ cord-345222-otfnrarh 274 6 bloody bloody JJ cord-345222-otfnrarh 274 7 diarrhea diarrhea NN cord-345222-otfnrarh 274 8 , , , cord-345222-otfnrarh 274 9 some some DT cord-345222-otfnrarh 274 10 studies study NNS cord-345222-otfnrarh 274 11 have have VBP cord-345222-otfnrarh 274 12 demonstrated demonstrate VBN cord-345222-otfnrarh 274 13 that that IN cord-345222-otfnrarh 274 14 E E NNP cord-345222-otfnrarh 274 15 histolytica histolytica NNP cord-345222-otfnrarh 274 16 could could MD cord-345222-otfnrarh 274 17 also also RB cord-345222-otfnrarh 274 18 be be VB cord-345222-otfnrarh 274 19 responsible responsible JJ cord-345222-otfnrarh 274 20 for for IN cord-345222-otfnrarh 274 21 watery watery JJ cord-345222-otfnrarh 274 22 diarrhea diarrhea NN cord-345222-otfnrarh 274 23 , , , cord-345222-otfnrarh 274 24 particularly particularly RB cord-345222-otfnrarh 274 25 in in IN cord-345222-otfnrarh 274 26 infants infant NNS cord-345222-otfnrarh 274 27 . . . cord-345222-otfnrarh 275 1 That that DT cord-345222-otfnrarh 275 2 nondysenteric nondysenteric JJ cord-345222-otfnrarh 275 3 diarrhea diarrhea NN cord-345222-otfnrarh 275 4 is be VBZ cord-345222-otfnrarh 275 5 a a DT cord-345222-otfnrarh 275 6 common common JJ cord-345222-otfnrarh 275 7 presentation presentation NN cord-345222-otfnrarh 275 8 of of IN cord-345222-otfnrarh 275 9 amebiasis amebiasis NN cord-345222-otfnrarh 275 10 in in IN cord-345222-otfnrarh 275 11 children child NNS cord-345222-otfnrarh 275 12 less less JJR cord-345222-otfnrarh 275 13 than than IN cord-345222-otfnrarh 275 14 2 2 CD cord-345222-otfnrarh 275 15 years year NNS cord-345222-otfnrarh 275 16 of of IN cord-345222-otfnrarh 275 17 age age NN cord-345222-otfnrarh 276 1 but but CC cord-345222-otfnrarh 276 2 it -PRON- PRP cord-345222-otfnrarh 276 3 was be VBD cord-345222-otfnrarh 276 4 also also RB cord-345222-otfnrarh 276 5 reported report VBN cord-345222-otfnrarh 276 6 among among IN cord-345222-otfnrarh 276 7 children child NNS cord-345222-otfnrarh 276 8 aged age VBN cord-345222-otfnrarh 276 9 2 2 CD cord-345222-otfnrarh 276 10 - - SYM cord-345222-otfnrarh 276 11 12 12 CD cord-345222-otfnrarh 276 12 years year NNS cord-345222-otfnrarh 276 13 of of IN cord-345222-otfnrarh 276 14 age age NN cord-345222-otfnrarh 276 15 . . . cord-345222-otfnrarh 277 1 94 94 CD cord-345222-otfnrarh 277 2 , , , cord-345222-otfnrarh 277 3 95 95 CD cord-345222-otfnrarh 278 1 Isospora Isospora NNP cord-345222-otfnrarh 278 2 belli belli NNP cord-345222-otfnrarh 278 3 is be VBZ cord-345222-otfnrarh 278 4 an an DT cord-345222-otfnrarh 278 5 opportunistic opportunistic JJ cord-345222-otfnrarh 278 6 protozoan protozoan NN cord-345222-otfnrarh 278 7 more more RBR cord-345222-otfnrarh 278 8 frequent frequent JJ cord-345222-otfnrarh 278 9 in in IN cord-345222-otfnrarh 278 10 developing develop VBG cord-345222-otfnrarh 278 11 countries country NNS cord-345222-otfnrarh 278 12 of of IN cord-345222-otfnrarh 278 13 tropical tropical JJ cord-345222-otfnrarh 278 14 and and CC cord-345222-otfnrarh 278 15 subtropical subtropical JJ cord-345222-otfnrarh 278 16 regions region NNS cord-345222-otfnrarh 278 17 and and CC cord-345222-otfnrarh 278 18 should should MD cord-345222-otfnrarh 278 19 be be VB cord-345222-otfnrarh 278 20 monitored monitor VBN cord-345222-otfnrarh 278 21 in in IN cord-345222-otfnrarh 278 22 both both DT cord-345222-otfnrarh 278 23 immunocompromised immunocompromised JJ cord-345222-otfnrarh 278 24 and and CC cord-345222-otfnrarh 278 25 immunocompetent immunocompetent JJ cord-345222-otfnrarh 278 26 patients patient NNS cord-345222-otfnrarh 278 27 with with IN cord-345222-otfnrarh 278 28 gastrointestinal gastrointestinal JJ cord-345222-otfnrarh 278 29 complaints complaint NNS cord-345222-otfnrarh 278 30 such such JJ cord-345222-otfnrarh 278 31 as as IN cord-345222-otfnrarh 278 32 abdominal abdominal JJ cord-345222-otfnrarh 278 33 pain pain NN cord-345222-otfnrarh 278 34 , , , cord-345222-otfnrarh 278 35 nausea nausea NN cord-345222-otfnrarh 278 36 , , , cord-345222-otfnrarh 278 37 and and CC cord-345222-otfnrarh 278 38 diarrhea diarrhea NN cord-345222-otfnrarh 278 39 . . . cord-345222-otfnrarh 279 1 Several several JJ cord-345222-otfnrarh 279 2 helminths helminth NNS cord-345222-otfnrarh 279 3 can can MD cord-345222-otfnrarh 279 4 also also RB cord-345222-otfnrarh 279 5 cause cause VB cord-345222-otfnrarh 279 6 diarrhea diarrhea NN cord-345222-otfnrarh 279 7 , , , cord-345222-otfnrarh 279 8 and and CC cord-345222-otfnrarh 279 9 their -PRON- PRP$ cord-345222-otfnrarh 279 10 importance importance NN cord-345222-otfnrarh 279 11 depends depend VBZ cord-345222-otfnrarh 279 12 on on IN cord-345222-otfnrarh 279 13 geographic geographic JJ cord-345222-otfnrarh 279 14 location location NN cord-345222-otfnrarh 279 15 , , , cord-345222-otfnrarh 279 16 climatic climatic JJ cord-345222-otfnrarh 279 17 conditions condition NNS cord-345222-otfnrarh 279 18 , , , cord-345222-otfnrarh 279 19 poor poor JJ cord-345222-otfnrarh 279 20 sanitation sanitation NN cord-345222-otfnrarh 279 21 , , , cord-345222-otfnrarh 279 22 unsafe unsafe JJ cord-345222-otfnrarh 279 23 drinking drinking NN cord-345222-otfnrarh 279 24 water water NN cord-345222-otfnrarh 279 25 , , , cord-345222-otfnrarh 279 26 and and CC cord-345222-otfnrarh 279 27 the the DT cord-345222-otfnrarh 279 28 immune immune JJ cord-345222-otfnrarh 279 29 status status NN cord-345222-otfnrarh 279 30 of of IN cord-345222-otfnrarh 279 31 the the DT cord-345222-otfnrarh 279 32 child child NN cord-345222-otfnrarh 279 33 . . . cord-345222-otfnrarh 280 1 6 6 CD cord-345222-otfnrarh 280 2 , , , cord-345222-otfnrarh 280 3 60 60 CD cord-345222-otfnrarh 280 4 Strongyloidiasis Strongyloidiasis NNP cord-345222-otfnrarh 280 5 is be VBZ cord-345222-otfnrarh 280 6 an an DT cord-345222-otfnrarh 280 7 infection infection NN cord-345222-otfnrarh 280 8 caused cause VBN cord-345222-otfnrarh 280 9 by by IN cord-345222-otfnrarh 280 10 the the DT cord-345222-otfnrarh 280 11 intestinal intestinal JJ cord-345222-otfnrarh 280 12 nematode nematode NN cord-345222-otfnrarh 280 13 Strongyloides Strongyloides NNP cord-345222-otfnrarh 280 14 stercoralis stercoralis NNP cord-345222-otfnrarh 280 15 . . . cord-345222-otfnrarh 281 1 Infected infect VBN cord-345222-otfnrarh 281 2 healthy healthy JJ cord-345222-otfnrarh 281 3 individuals individual NNS cord-345222-otfnrarh 281 4 are be VBP cord-345222-otfnrarh 281 5 usually usually RB cord-345222-otfnrarh 281 6 asymptomatic asymptomatic JJ cord-345222-otfnrarh 281 7 ; ; : cord-345222-otfnrarh 281 8 however however RB cord-345222-otfnrarh 281 9 , , , cord-345222-otfnrarh 281 10 it -PRON- PRP cord-345222-otfnrarh 281 11 can can MD cord-345222-otfnrarh 281 12 cause cause VB cord-345222-otfnrarh 281 13 watery watery JJ cord-345222-otfnrarh 281 14 or or CC cord-345222-otfnrarh 281 15 chronic chronic JJ cord-345222-otfnrarh 281 16 diarrhea diarrhea NN cord-345222-otfnrarh 281 17 , , , cord-345222-otfnrarh 281 18 abdominal abdominal JJ cord-345222-otfnrarh 281 19 cramping cramping NN cord-345222-otfnrarh 281 20 , , , cord-345222-otfnrarh 281 21 failure failure NN cord-345222-otfnrarh 281 22 to to TO cord-345222-otfnrarh 281 23 thrive thrive VB cord-345222-otfnrarh 281 24 , , , cord-345222-otfnrarh 281 25 and and CC cord-345222-otfnrarh 281 26 cachexia cachexia NN cord-345222-otfnrarh 281 27 . . . cord-345222-otfnrarh 282 1 It -PRON- PRP cord-345222-otfnrarh 282 2 is be VBZ cord-345222-otfnrarh 282 3 potentially potentially RB cord-345222-otfnrarh 282 4 fatal fatal JJ cord-345222-otfnrarh 282 5 in in IN cord-345222-otfnrarh 282 6 immunocompromised immunocompromised JJ cord-345222-otfnrarh 282 7 hosts host NNS cord-345222-otfnrarh 282 8 , , , cord-345222-otfnrarh 282 9 due due IN cord-345222-otfnrarh 282 10 to to IN cord-345222-otfnrarh 282 11 its -PRON- PRP$ cord-345222-otfnrarh 282 12 capacity capacity NN cord-345222-otfnrarh 282 13 to to TO cord-345222-otfnrarh 282 14 cause cause VB cord-345222-otfnrarh 282 15 an an DT cord-345222-otfnrarh 282 16 overwhelming overwhelming JJ cord-345222-otfnrarh 282 17 hyperinfection hyperinfection NN cord-345222-otfnrarh 282 18 . . . cord-345222-otfnrarh 283 1 A a DT cord-345222-otfnrarh 283 2 screening screening NN cord-345222-otfnrarh 283 3 assay assay NN cord-345222-otfnrarh 283 4 for for IN cord-345222-otfnrarh 283 5 Strongyloides Strongyloides NNP cord-345222-otfnrarh 283 6 infection infection NN cord-345222-otfnrarh 283 7 in in IN cord-345222-otfnrarh 283 8 suspected suspect VBN cord-345222-otfnrarh 283 9 patients patient NNS cord-345222-otfnrarh 283 10 is be VBZ cord-345222-otfnrarh 283 11 needed need VBN cord-345222-otfnrarh 283 12 for for IN cord-345222-otfnrarh 283 13 early early JJ cord-345222-otfnrarh 283 14 detection detection NN cord-345222-otfnrarh 283 15 and and CC cord-345222-otfnrarh 283 16 successful successful JJ cord-345222-otfnrarh 283 17 cure cure NN cord-345222-otfnrarh 283 18 . . . cord-345222-otfnrarh 284 1 96 96 CD cord-345222-otfnrarh 285 1 Trichuris Trichuris NNP cord-345222-otfnrarh 285 2 trichiura trichiura NN cord-345222-otfnrarh 285 3 infections infection NNS cord-345222-otfnrarh 285 4 are be VBP cord-345222-otfnrarh 285 5 widespread widespread JJ cord-345222-otfnrarh 285 6 globally globally RB cord-345222-otfnrarh 285 7 , , , cord-345222-otfnrarh 285 8 with with IN cord-345222-otfnrarh 285 9 prevalence prevalence NN cord-345222-otfnrarh 285 10 and and CC cord-345222-otfnrarh 285 11 intensity intensity NN cord-345222-otfnrarh 285 12 - - HYPH cord-345222-otfnrarh 285 13 of of IN cord-345222-otfnrarh 285 14 - - HYPH cord-345222-otfnrarh 285 15 infection infection NN cord-345222-otfnrarh 285 16 peaks peak NNS cord-345222-otfnrarh 285 17 in in IN cord-345222-otfnrarh 285 18 school school NN cord-345222-otfnrarh 285 19 age age NN cord-345222-otfnrarh 285 20 . . . cord-345222-otfnrarh 286 1 Nevertheless nevertheless RB cord-345222-otfnrarh 286 2 , , , cord-345222-otfnrarh 286 3 as as RB cord-345222-otfnrarh 286 4 soon soon RB cord-345222-otfnrarh 286 5 as as IN cord-345222-otfnrarh 286 6 infants infant NNS cord-345222-otfnrarh 286 7 start start VBP cord-345222-otfnrarh 286 8 to to TO cord-345222-otfnrarh 286 9 explore explore VB cord-345222-otfnrarh 286 10 their -PRON- PRP$ cord-345222-otfnrarh 286 11 environment environment NN cord-345222-otfnrarh 286 12 , , , cord-345222-otfnrarh 286 13 thus thus RB cord-345222-otfnrarh 286 14 coming come VBG cord-345222-otfnrarh 286 15 into into IN cord-345222-otfnrarh 286 16 contact contact NN cord-345222-otfnrarh 286 17 with with IN cord-345222-otfnrarh 286 18 contaminated contaminated JJ cord-345222-otfnrarh 286 19 soil soil NN cord-345222-otfnrarh 286 20 , , , cord-345222-otfnrarh 286 21 they -PRON- PRP cord-345222-otfnrarh 286 22 are be VBP cord-345222-otfnrarh 286 23 at at IN cord-345222-otfnrarh 286 24 risk risk NN cord-345222-otfnrarh 286 25 of of IN cord-345222-otfnrarh 286 26 infection infection NN cord-345222-otfnrarh 286 27 according accord VBG cord-345222-otfnrarh 286 28 to to IN cord-345222-otfnrarh 286 29 the the DT cord-345222-otfnrarh 286 30 levels level NNS cord-345222-otfnrarh 286 31 of of IN cord-345222-otfnrarh 286 32 transmission transmission NN cord-345222-otfnrarh 286 33 in in IN cord-345222-otfnrarh 286 34 the the DT cord-345222-otfnrarh 286 35 area area NN cord-345222-otfnrarh 286 36 . . . cord-345222-otfnrarh 287 1 The the DT cord-345222-otfnrarh 287 2 pathogen pathogen NN cord-345222-otfnrarh 287 3 can can MD cord-345222-otfnrarh 287 4 cause cause VB cord-345222-otfnrarh 287 5 inflammatory inflammatory JJ cord-345222-otfnrarh 287 6 damage damage NN cord-345222-otfnrarh 287 7 to to IN cord-345222-otfnrarh 287 8 mucosa mucosa JJ cord-345222-otfnrarh 287 9 , , , cord-345222-otfnrarh 287 10 bloody bloody JJ cord-345222-otfnrarh 287 11 diarrhea diarrhea NN cord-345222-otfnrarh 287 12 , , , cord-345222-otfnrarh 287 13 iron iron NN cord-345222-otfnrarh 287 14 deficiency deficiency NN cord-345222-otfnrarh 287 15 , , , cord-345222-otfnrarh 287 16 and and CC cord-345222-otfnrarh 287 17 anemia anemia NN cord-345222-otfnrarh 287 18 . . . cord-345222-otfnrarh 288 1 Most Most JJS cord-345222-otfnrarh 288 2 children child NNS cord-345222-otfnrarh 288 3 with with IN cord-345222-otfnrarh 288 4 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 288 5 do do VBP cord-345222-otfnrarh 288 6 not not RB cord-345222-otfnrarh 288 7 require require VB cord-345222-otfnrarh 288 8 any any DT cord-345222-otfnrarh 288 9 laboratory laboratory NN cord-345222-otfnrarh 288 10 investigations investigation NNS cord-345222-otfnrarh 288 11 . . . cord-345222-otfnrarh 289 1 Many many JJ cord-345222-otfnrarh 289 2 infants infant NNS cord-345222-otfnrarh 289 3 and and CC cord-345222-otfnrarh 289 4 children child NNS cord-345222-otfnrarh 289 5 experience experience VBP cord-345222-otfnrarh 289 6 brief brief JJ cord-345222-otfnrarh 289 7 episodes episode NNS cord-345222-otfnrarh 289 8 of of IN cord-345222-otfnrarh 289 9 diarrhea diarrhea NN cord-345222-otfnrarh 289 10 , , , cord-345222-otfnrarh 289 11 and and CC cord-345222-otfnrarh 289 12 are be VBP cord-345222-otfnrarh 289 13 managed manage VBN cord-345222-otfnrarh 289 14 by by IN cord-345222-otfnrarh 289 15 their -PRON- PRP$ cord-345222-otfnrarh 289 16 parents parent NNS cord-345222-otfnrarh 289 17 without without IN cord-345222-otfnrarh 289 18 seeking seek VBG cord-345222-otfnrarh 289 19 professional professional JJ cord-345222-otfnrarh 289 20 advice advice NN cord-345222-otfnrarh 289 21 . . . cord-345222-otfnrarh 290 1 Even even RB cord-345222-otfnrarh 290 2 if if IN cord-345222-otfnrarh 290 3 advice advice NN cord-345222-otfnrarh 290 4 is be VBZ cord-345222-otfnrarh 290 5 sought seek VBN cord-345222-otfnrarh 290 6 , , , cord-345222-otfnrarh 290 7 health health NN cord-345222-otfnrarh 290 8 care care NN cord-345222-otfnrarh 290 9 professionals professional NNS cord-345222-otfnrarh 290 10 often often RB cord-345222-otfnrarh 290 11 consider consider VBP cord-345222-otfnrarh 290 12 that that IN cord-345222-otfnrarh 290 13 a a DT cord-345222-otfnrarh 290 14 clinical clinical JJ cord-345222-otfnrarh 290 15 assessment assessment NN cord-345222-otfnrarh 290 16 is be VBZ cord-345222-otfnrarh 290 17 all all DT cord-345222-otfnrarh 290 18 that that WDT cord-345222-otfnrarh 290 19 is be VBZ cord-345222-otfnrarh 290 20 required require VBN cord-345222-otfnrarh 290 21 , , , cord-345222-otfnrarh 290 22 and and CC cord-345222-otfnrarh 290 23 laboratory laboratory NN cord-345222-otfnrarh 290 24 investigations investigation NNS cord-345222-otfnrarh 290 25 are be VBP cord-345222-otfnrarh 290 26 not not RB cord-345222-otfnrarh 290 27 undertaken undertake VBN cord-345222-otfnrarh 290 28 . . . cord-345222-otfnrarh 291 1 4 4 LS cord-345222-otfnrarh 292 1 However however RB cord-345222-otfnrarh 292 2 , , , cord-345222-otfnrarh 292 3 there there EX cord-345222-otfnrarh 292 4 may may MD cord-345222-otfnrarh 292 5 be be VB cord-345222-otfnrarh 292 6 particular particular JJ cord-345222-otfnrarh 292 7 circumstances circumstance NNS cord-345222-otfnrarh 292 8 when when WRB cord-345222-otfnrarh 292 9 investigations investigation NNS cord-345222-otfnrarh 292 10 may may MD cord-345222-otfnrarh 292 11 be be VB cord-345222-otfnrarh 292 12 helpful helpful JJ cord-345222-otfnrarh 292 13 in in IN cord-345222-otfnrarh 292 14 diagnosis diagnosis NN cord-345222-otfnrarh 292 15 . . . cord-345222-otfnrarh 293 1 Frequently frequently RB cord-345222-otfnrarh 293 2 the the DT cord-345222-otfnrarh 293 3 signs sign NNS cord-345222-otfnrarh 293 4 and and CC cord-345222-otfnrarh 293 5 symptoms symptom NNS cord-345222-otfnrarh 293 6 are be VBP cord-345222-otfnrarh 293 7 not not RB cord-345222-otfnrarh 293 8 sufficient sufficient JJ cord-345222-otfnrarh 293 9 to to TO cord-345222-otfnrarh 293 10 make make VB cord-345222-otfnrarh 293 11 an an DT cord-345222-otfnrarh 293 12 etiological etiological JJ cord-345222-otfnrarh 293 13 diagnosis diagnosis NN cord-345222-otfnrarh 293 14 as as IN cord-345222-otfnrarh 293 15 they -PRON- PRP cord-345222-otfnrarh 293 16 often often RB cord-345222-otfnrarh 293 17 are be VBP cord-345222-otfnrarh 293 18 nonspecific nonspecific JJ cord-345222-otfnrarh 293 19 . . . cord-345222-otfnrarh 294 1 The the DT cord-345222-otfnrarh 294 2 localization localization NN cord-345222-otfnrarh 294 3 of of IN cord-345222-otfnrarh 294 4 the the DT cord-345222-otfnrarh 294 5 pathogen pathogen NN cord-345222-otfnrarh 294 6 in in IN cord-345222-otfnrarh 294 7 the the DT cord-345222-otfnrarh 294 8 small small JJ cord-345222-otfnrarh 294 9 intestine intestine NN cord-345222-otfnrarh 294 10 or or CC cord-345222-otfnrarh 294 11 in in IN cord-345222-otfnrarh 294 12 the the DT cord-345222-otfnrarh 294 13 colon colon NN cord-345222-otfnrarh 294 14 , , , cord-345222-otfnrarh 294 15 the the DT cord-345222-otfnrarh 294 16 characteristics characteristic NNS cord-345222-otfnrarh 294 17 of of IN cord-345222-otfnrarh 294 18 the the DT cord-345222-otfnrarh 294 19 feces fece NNS cord-345222-otfnrarh 294 20 ( ( -LRB- cord-345222-otfnrarh 294 21 Table table NN cord-345222-otfnrarh 294 22 2 2 CD cord-345222-otfnrarh 294 23 ) ) -RRB- cord-345222-otfnrarh 294 24 , , , cord-345222-otfnrarh 294 25 the the DT cord-345222-otfnrarh 294 26 clinical clinical JJ cord-345222-otfnrarh 294 27 history history NN cord-345222-otfnrarh 294 28 of of IN cord-345222-otfnrarh 294 29 the the DT cord-345222-otfnrarh 294 30 disease disease NN cord-345222-otfnrarh 294 31 , , , cord-345222-otfnrarh 294 32 and and CC cord-345222-otfnrarh 294 33 environmental environmental JJ cord-345222-otfnrarh 294 34 risk risk NN cord-345222-otfnrarh 294 35 factors factor NNS cord-345222-otfnrarh 294 36 can can MD cord-345222-otfnrarh 294 37 support support VB cord-345222-otfnrarh 294 38 the the DT cord-345222-otfnrarh 294 39 diagnostic diagnostic JJ cord-345222-otfnrarh 294 40 evaluation evaluation NN cord-345222-otfnrarh 294 41 . . . cord-345222-otfnrarh 295 1 It -PRON- PRP cord-345222-otfnrarh 295 2 would would MD cord-345222-otfnrarh 295 3 be be VB cord-345222-otfnrarh 295 4 also also RB cord-345222-otfnrarh 295 5 important important JJ cord-345222-otfnrarh 295 6 to to TO cord-345222-otfnrarh 295 7 be be VB cord-345222-otfnrarh 295 8 aware aware JJ cord-345222-otfnrarh 295 9 of of IN cord-345222-otfnrarh 295 10 any any DT cord-345222-otfnrarh 295 11 history history NN cord-345222-otfnrarh 295 12 of of IN cord-345222-otfnrarh 295 13 recent recent JJ cord-345222-otfnrarh 295 14 contact contact NN cord-345222-otfnrarh 295 15 with with IN cord-345222-otfnrarh 295 16 someone someone NN cord-345222-otfnrarh 295 17 with with IN cord-345222-otfnrarh 295 18 acute acute JJ cord-345222-otfnrarh 295 19 diarrhoea diarrhoea NN cord-345222-otfnrarh 295 20 and/or and/or CC cord-345222-otfnrarh 295 21 vomiting vomiting NN cord-345222-otfnrarh 295 22 and and CC cord-345222-otfnrarh 295 23 exposure exposure NN cord-345222-otfnrarh 295 24 to to IN cord-345222-otfnrarh 295 25 a a DT cord-345222-otfnrarh 295 26 known know VBN cord-345222-otfnrarh 295 27 source source NN cord-345222-otfnrarh 295 28 of of IN cord-345222-otfnrarh 295 29 enteric enteric JJ cord-345222-otfnrarh 295 30 infection infection NN cord-345222-otfnrarh 295 31 ( ( -LRB- cord-345222-otfnrarh 295 32 possibly possibly RB cord-345222-otfnrarh 295 33 contaminated contaminated JJ cord-345222-otfnrarh 295 34 water water NN cord-345222-otfnrarh 295 35 or or CC cord-345222-otfnrarh 295 36 food food NN cord-345222-otfnrarh 295 37 ) ) -RRB- cord-345222-otfnrarh 295 38 or or CC cord-345222-otfnrarh 295 39 a a DT cord-345222-otfnrarh 295 40 recent recent JJ cord-345222-otfnrarh 295 41 travel travel NN cord-345222-otfnrarh 295 42 abroad abroad RB cord-345222-otfnrarh 295 43 . . . cord-345222-otfnrarh 296 1 4 4 LS cord-345222-otfnrarh 296 2 Severe severe JJ cord-345222-otfnrarh 296 3 watery watery JJ cord-345222-otfnrarh 296 4 diarrhea diarrhea NN cord-345222-otfnrarh 296 5 in in IN cord-345222-otfnrarh 296 6 the the DT cord-345222-otfnrarh 296 7 absence absence NN cord-345222-otfnrarh 296 8 of of IN cord-345222-otfnrarh 296 9 mucus mucus NN cord-345222-otfnrarh 296 10 , , , cord-345222-otfnrarh 296 11 pus pus NN cord-345222-otfnrarh 296 12 , , , cord-345222-otfnrarh 296 13 or or CC cord-345222-otfnrarh 296 14 blood blood NN cord-345222-otfnrarh 296 15 suggests suggest VBZ cord-345222-otfnrarh 296 16 secretory secretory JJ cord-345222-otfnrarh 296 17 diarrhea diarrhea NN cord-345222-otfnrarh 296 18 or or CC cord-345222-otfnrarh 296 19 malabsorption malabsorption NN cord-345222-otfnrarh 296 20 ( ( -LRB- cord-345222-otfnrarh 296 21 such such JJ cord-345222-otfnrarh 296 22 as as IN cord-345222-otfnrarh 296 23 by by IN cord-345222-otfnrarh 296 24 noninvasive noninvasive JJ cord-345222-otfnrarh 296 25 Vibrio Vibrio NNP cord-345222-otfnrarh 296 26 cholera cholera NN cord-345222-otfnrarh 296 27 , , , cord-345222-otfnrarh 296 28 ETEC ETEC NNP cord-345222-otfnrarh 296 29 , , , cord-345222-otfnrarh 296 30 or or CC cord-345222-otfnrarh 296 31 by by IN cord-345222-otfnrarh 296 32 rotavirus rotavirus NN cord-345222-otfnrarh 296 33 , , , cord-345222-otfnrarh 296 34 adenovirus adenovirus NN cord-345222-otfnrarh 296 35 , , , cord-345222-otfnrarh 296 36 or or CC cord-345222-otfnrarh 296 37 astrovirus astrovirus NNP cord-345222-otfnrarh 296 38 ) ) -RRB- cord-345222-otfnrarh 296 39 , , , cord-345222-otfnrarh 296 40 while while IN cord-345222-otfnrarh 296 41 the the DT cord-345222-otfnrarh 296 42 presence presence NN cord-345222-otfnrarh 296 43 of of IN cord-345222-otfnrarh 296 44 blood blood NN cord-345222-otfnrarh 296 45 and and CC cord-345222-otfnrarh 296 46 mucus mucus NN cord-345222-otfnrarh 296 47 are be VBP cord-345222-otfnrarh 296 48 more more RBR cord-345222-otfnrarh 296 49 indicative indicative JJ cord-345222-otfnrarh 296 50 of of IN cord-345222-otfnrarh 296 51 an an DT cord-345222-otfnrarh 296 52 invasive invasive JJ cord-345222-otfnrarh 296 53 germ germ NN cord-345222-otfnrarh 296 54 , , , cord-345222-otfnrarh 296 55 such such JJ cord-345222-otfnrarh 296 56 as as IN cord-345222-otfnrarh 296 57 Salmonella Salmonella NNP cord-345222-otfnrarh 296 58 , , , cord-345222-otfnrarh 296 59 Shigella Shigella NNP cord-345222-otfnrarh 296 60 , , , cord-345222-otfnrarh 296 61 Campylobacter Campylobacter NNP cord-345222-otfnrarh 296 62 jejuni jejuni NNP cord-345222-otfnrarh 296 63 , , , cord-345222-otfnrarh 296 64 or or CC cord-345222-otfnrarh 296 65 Yersinia Yersinia NNP cord-345222-otfnrarh 296 66 enterocolitica enterocolitica NNP cord-345222-otfnrarh 296 67 . . . cord-345222-otfnrarh 297 1 60 60 CD cord-345222-otfnrarh 298 1 The the DT cord-345222-otfnrarh 298 2 presence presence NN cord-345222-otfnrarh 298 3 of of IN cord-345222-otfnrarh 298 4 vomiting vomiting NN cord-345222-otfnrarh 298 5 and and CC cord-345222-otfnrarh 298 6 fever fever NN cord-345222-otfnrarh 298 7 with with IN cord-345222-otfnrarh 298 8 diarrhea diarrhea NN cord-345222-otfnrarh 298 9 is be VBZ cord-345222-otfnrarh 298 10 nonspecific nonspecific JJ cord-345222-otfnrarh 298 11 and and CC cord-345222-otfnrarh 298 12 can can MD cord-345222-otfnrarh 298 13 not not RB cord-345222-otfnrarh 298 14 help help VB cord-345222-otfnrarh 298 15 in in IN cord-345222-otfnrarh 298 16 the the DT cord-345222-otfnrarh 298 17 diagnosis diagnosis NN cord-345222-otfnrarh 298 18 . . . cord-345222-otfnrarh 299 1 4 4 LS cord-345222-otfnrarh 300 1 It -PRON- PRP cord-345222-otfnrarh 300 2 would would MD cord-345222-otfnrarh 300 3 be be VB cord-345222-otfnrarh 300 4 also also RB cord-345222-otfnrarh 300 5 important important JJ cord-345222-otfnrarh 300 6 to to TO cord-345222-otfnrarh 300 7 be be VB cord-345222-otfnrarh 300 8 aware aware JJ cord-345222-otfnrarh 300 9 of of IN cord-345222-otfnrarh 300 10 any any DT cord-345222-otfnrarh 300 11 history history NN cord-345222-otfnrarh 300 12 of of IN cord-345222-otfnrarh 300 13 recent recent JJ cord-345222-otfnrarh 300 14 contact contact NN cord-345222-otfnrarh 300 15 with with IN cord-345222-otfnrarh 300 16 submit submit NN cord-345222-otfnrarh 301 1 your -PRON- PRP$ cord-345222-otfnrarh 301 2 manuscript manuscript NN cord-345222-otfnrarh 301 3 | | POS cord-345222-otfnrarh 301 4 www.dovepress.com www.dovepress.com NNP cord-345222-otfnrarh 301 5 1 1 CD cord-345222-otfnrarh 301 6 year year NN cord-345222-otfnrarh 301 7 and and CC cord-345222-otfnrarh 301 8 a a DT cord-345222-otfnrarh 301 9 few few JJ cord-345222-otfnrarh 301 10 percent percent NN cord-345222-otfnrarh 301 11 of of IN cord-345222-otfnrarh 301 12 adults adult NNS cord-345222-otfnrarh 301 13 . . . cord-345222-otfnrarh 302 1 Although although IN cord-345222-otfnrarh 302 2 these these DT cord-345222-otfnrarh 302 3 data datum NNS cord-345222-otfnrarh 302 4 support support VBP cord-345222-otfnrarh 302 5 the the DT cord-345222-otfnrarh 302 6 potential potential NN cord-345222-otfnrarh 302 7 for for IN cord-345222-otfnrarh 302 8 endogenous endogenous JJ cord-345222-otfnrarh 302 9 sources source NNS cord-345222-otfnrarh 302 10 of of IN cord-345222-otfnrarh 302 11 human human JJ cord-345222-otfnrarh 302 12 infection infection NN cord-345222-otfnrarh 302 13 , , , cord-345222-otfnrarh 302 14 there there EX cord-345222-otfnrarh 302 15 was be VBD cord-345222-otfnrarh 302 16 early early JJ cord-345222-otfnrarh 302 17 cir cir NNP cord-345222-otfnrarh 302 18 cumstantial cumstantial NN cord-345222-otfnrarh 302 19 evidence evidence NN cord-345222-otfnrarh 302 20 to to TO cord-345222-otfnrarh 302 21 suggest suggest VB cord-345222-otfnrarh 302 22 that that IN cord-345222-otfnrarh 302 23 this this DT cord-345222-otfnrarh 302 24 pathogen pathogen NN cord-345222-otfnrarh 302 25 could could MD cord-345222-otfnrarh 302 26 be be VB cord-345222-otfnrarh 302 27 transmissible transmissible JJ cord-345222-otfnrarh 302 28 and and CC cord-345222-otfnrarh 302 29 acquired acquire VBN cord-345222-otfnrarh 302 30 from from IN cord-345222-otfnrarh 302 31 external external JJ cord-345222-otfnrarh 302 32 sources source NNS cord-345222-otfnrarh 302 33 . . . cord-345222-otfnrarh 303 1 97 97 CD cord-345222-otfnrarh 304 1 Therefore therefore RB cord-345222-otfnrarh 304 2 the the DT cord-345222-otfnrarh 304 3 possibility possibility NN cord-345222-otfnrarh 304 4 of of IN cord-345222-otfnrarh 304 5 other other JJ cord-345222-otfnrarh 304 6 disorders disorder NNS cord-345222-otfnrarh 304 7 would would MD cord-345222-otfnrarh 304 8 require require VB cord-345222-otfnrarh 304 9 careful careful JJ cord-345222-otfnrarh 304 10 consideration consideration NN cord-345222-otfnrarh 304 11 in in IN cord-345222-otfnrarh 304 12 such such JJ cord-345222-otfnrarh 304 13 cases case NNS cord-345222-otfnrarh 304 14 of of IN cord-345222-otfnrarh 304 15 diarrhea diarrhea NN cord-345222-otfnrarh 304 16 and/or and/or CC cord-345222-otfnrarh 304 17 vomiting vomit VBG cord-345222-otfnrarh 304 18 as as IN cord-345222-otfnrarh 304 19 shown show VBN cord-345222-otfnrarh 304 20 in in IN cord-345222-otfnrarh 304 21 Table Table NNP cord-345222-otfnrarh 304 22 3 3 CD cord-345222-otfnrarh 304 23 . . . cord-345222-otfnrarh 305 1 Regarding regard VBG cord-345222-otfnrarh 305 2 collection collection NN cord-345222-otfnrarh 305 3 and and CC cord-345222-otfnrarh 305 4 transport transport NN cord-345222-otfnrarh 305 5 of of IN cord-345222-otfnrarh 305 6 stool stool NN cord-345222-otfnrarh 305 7 specimens specimen NNS cord-345222-otfnrarh 305 8 , , , cord-345222-otfnrarh 305 9 for for IN cord-345222-otfnrarh 305 10 stool stool NN cord-345222-otfnrarh 305 11 culture culture NN cord-345222-otfnrarh 305 12 for for IN cord-345222-otfnrarh 305 13 bacterial bacterial JJ cord-345222-otfnrarh 305 14 pathogens pathogen NNS cord-345222-otfnrarh 305 15 : : : cord-345222-otfnrarh 305 16 one one CD cord-345222-otfnrarh 305 17 stool stool NN cord-345222-otfnrarh 305 18 specimen specimen NN cord-345222-otfnrarh 305 19 is be VBZ cord-345222-otfnrarh 305 20 sufficient sufficient JJ cord-345222-otfnrarh 305 21 in in IN cord-345222-otfnrarh 305 22 most most JJS cord-345222-otfnrarh 305 23 cases case NNS cord-345222-otfnrarh 305 24 : : : cord-345222-otfnrarh 306 1 • • NNP cord-345222-otfnrarh 306 2 C. c. NN cord-345222-otfnrarh 306 3 difficile difficile NN cord-345222-otfnrarh 306 4 toxin toxin NN cord-345222-otfnrarh 306 5 testing testing NN cord-345222-otfnrarh 306 6 : : : cord-345222-otfnrarh 306 7 one one CD cord-345222-otfnrarh 306 8 stool stool NN cord-345222-otfnrarh 306 9 specimen specimen NN cord-345222-otfnrarh 306 10 is be VBZ cord-345222-otfnrarh 306 11 sufficient sufficient JJ cord-345222-otfnrarh 306 12 in in IN cord-345222-otfnrarh 306 13 most most JJS cord-345222-otfnrarh 306 14 cases case NNS cord-345222-otfnrarh 306 15 . . . cord-345222-otfnrarh 307 1 • • NNP cord-345222-otfnrarh 308 1 ova ova NNP cord-345222-otfnrarh 308 2 and and CC cord-345222-otfnrarh 308 3 parasite parasite NN cord-345222-otfnrarh 308 4 testing testing NN cord-345222-otfnrarh 308 5 : : : cord-345222-otfnrarh 308 6 specimen specimen NN cord-345222-otfnrarh 308 7 must must MD cord-345222-otfnrarh 308 8 be be VB cord-345222-otfnrarh 308 9 submitted submit VBN cord-345222-otfnrarh 308 10 in in IN cord-345222-otfnrarh 308 11 an an DT cord-345222-otfnrarh 308 12 appropriate appropriate JJ cord-345222-otfnrarh 308 13 preservative preservative NN cord-345222-otfnrarh 308 14 ( ( -LRB- cord-345222-otfnrarh 308 15 sodium sodium NN cord-345222-otfnrarh 308 16 acetate acetate NN cord-345222-otfnrarh 308 17 - - HYPH cord-345222-otfnrarh 308 18 acetic acetic JJ cord-345222-otfnrarh 308 19 acidformalin acidformalin NN cord-345222-otfnrarh 308 20 fixative fixative NN cord-345222-otfnrarh 308 21 ) ) -RRB- cord-345222-otfnrarh 308 22 . . . cord-345222-otfnrarh 309 1 • • NNP cord-345222-otfnrarh 310 1 viral viral JJ cord-345222-otfnrarh 310 2 pathogens pathogen NNS cord-345222-otfnrarh 310 3 : : : cord-345222-otfnrarh 310 4 stool stool VB cord-345222-otfnrarh 310 5 for for IN cord-345222-otfnrarh 310 6 viral viral JJ cord-345222-otfnrarh 310 7 pathogens pathogen NNS cord-345222-otfnrarh 310 8 are be VBP cord-345222-otfnrarh 310 9 not not RB cord-345222-otfnrarh 310 10 routinely routinely RB cord-345222-otfnrarh 310 11 tested test VBN cord-345222-otfnrarh 310 12 ; ; : cord-345222-otfnrarh 310 13 for for IN cord-345222-otfnrarh 310 14 a a DT cord-345222-otfnrarh 310 15 suspected suspect VBN cord-345222-otfnrarh 310 16 outbreak outbreak NN cord-345222-otfnrarh 310 17 of of IN cord-345222-otfnrarh 310 18 viral viral JJ cord-345222-otfnrarh 310 19 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 310 20 , , , cord-345222-otfnrarh 310 21 one one CD cord-345222-otfnrarh 310 22 stool stool NN cord-345222-otfnrarh 310 23 specimen specimen NN cord-345222-otfnrarh 310 24 submitted submit VBN cord-345222-otfnrarh 310 25 in in IN cord-345222-otfnrarh 310 26 a a DT cord-345222-otfnrarh 310 27 sterile sterile JJ cord-345222-otfnrarh 310 28 container container NN cord-345222-otfnrarh 310 29 is be VBZ cord-345222-otfnrarh 310 30 sufficient sufficient JJ cord-345222-otfnrarh 310 31 in in IN cord-345222-otfnrarh 310 32 most most JJS cord-345222-otfnrarh 310 33 cases case NNS cord-345222-otfnrarh 310 34 . . . cord-345222-otfnrarh 311 1 For for IN cord-345222-otfnrarh 311 2 the the DT cord-345222-otfnrarh 311 3 investigation investigation NN cord-345222-otfnrarh 311 4 of of IN cord-345222-otfnrarh 311 5 bacterial bacterial JJ cord-345222-otfnrarh 311 6 pathogens pathogen NNS cord-345222-otfnrarh 311 7 , , , cord-345222-otfnrarh 311 8 stool stool NN cord-345222-otfnrarh 311 9 specimens specimen NNS cord-345222-otfnrarh 311 10 should should MD cord-345222-otfnrarh 311 11 be be VB cord-345222-otfnrarh 311 12 delivered deliver VBN cord-345222-otfnrarh 311 13 to to IN cord-345222-otfnrarh 311 14 the the DT cord-345222-otfnrarh 311 15 laboratory laboratory NN cord-345222-otfnrarh 311 16 as as RB cord-345222-otfnrarh 311 17 soon soon RB cord-345222-otfnrarh 311 18 as as IN cord-345222-otfnrarh 311 19 possible possible JJ cord-345222-otfnrarh 311 20 , , , cord-345222-otfnrarh 311 21 as as IN cord-345222-otfnrarh 311 22 a a DT cord-345222-otfnrarh 311 23 delay delay NN cord-345222-otfnrarh 311 24 may may MD cord-345222-otfnrarh 311 25 compromise compromise VB cord-345222-otfnrarh 311 26 bacterial bacterial JJ cord-345222-otfnrarh 311 27 pathogen pathogen NN cord-345222-otfnrarh 311 28 recovery recovery NN cord-345222-otfnrarh 311 29 . . . cord-345222-otfnrarh 312 1 A a DT cord-345222-otfnrarh 312 2 single single JJ cord-345222-otfnrarh 312 3 stool stool NN cord-345222-otfnrarh 312 4 specimen specimen NN cord-345222-otfnrarh 312 5 , , , cord-345222-otfnrarh 312 6 properly properly RB cord-345222-otfnrarh 312 7 collected collect VBN cord-345222-otfnrarh 312 8 and and CC cord-345222-otfnrarh 312 9 promptly promptly RB cord-345222-otfnrarh 312 10 submitted submit VBN cord-345222-otfnrarh 312 11 , , , cord-345222-otfnrarh 312 12 will will MD cord-345222-otfnrarh 312 13 identify identify VB cord-345222-otfnrarh 312 14 most most JJS cord-345222-otfnrarh 312 15 patients patient NNS cord-345222-otfnrarh 312 16 with with IN cord-345222-otfnrarh 312 17 a a DT cord-345222-otfnrarh 312 18 bacterial bacterial JJ cord-345222-otfnrarh 312 19 pathogen pathogen NN cord-345222-otfnrarh 312 20 . . . cord-345222-otfnrarh 313 1 Additional additional JJ cord-345222-otfnrarh 313 2 stool stool NN cord-345222-otfnrarh 313 3 specimens specimen NNS cord-345222-otfnrarh 313 4 need need VBP cord-345222-otfnrarh 313 5 to to TO cord-345222-otfnrarh 313 6 be be VB cord-345222-otfnrarh 313 7 submitted submit VBN cord-345222-otfnrarh 313 8 if if IN cord-345222-otfnrarh 313 9 the the DT cord-345222-otfnrarh 313 10 culture culture NN cord-345222-otfnrarh 313 11 results result NNS cord-345222-otfnrarh 313 12 are be VBP cord-345222-otfnrarh 313 13 negative negative JJ cord-345222-otfnrarh 313 14 , , , cord-345222-otfnrarh 313 15 symptoms symptom NNS cord-345222-otfnrarh 313 16 persist persist VBP cord-345222-otfnrarh 313 17 , , , cord-345222-otfnrarh 313 18 and and CC cord-345222-otfnrarh 313 19 other other JJ cord-345222-otfnrarh 313 20 causes cause NNS cord-345222-otfnrarh 313 21 can can MD cord-345222-otfnrarh 313 22 not not RB cord-345222-otfnrarh 313 23 be be VB cord-345222-otfnrarh 313 24 found find VBN cord-345222-otfnrarh 313 25 . . . cord-345222-otfnrarh 314 1 If if IN cord-345222-otfnrarh 314 2 there there EX cord-345222-otfnrarh 314 3 are be VBP cord-345222-otfnrarh 314 4 concerns concern NNS cord-345222-otfnrarh 314 5 regarding regard VBG cord-345222-otfnrarh 314 6 timing timing NN cord-345222-otfnrarh 314 7 or or CC cord-345222-otfnrarh 314 8 transport transport NN cord-345222-otfnrarh 314 9 of of IN cord-345222-otfnrarh 314 10 the the DT cord-345222-otfnrarh 314 11 specimen specimen NN cord-345222-otfnrarh 314 12 , , , cord-345222-otfnrarh 314 13 consult consult VB cord-345222-otfnrarh 314 14 the the DT cord-345222-otfnrarh 314 15 laboratory laboratory NN cord-345222-otfnrarh 314 16 . . . cord-345222-otfnrarh 315 1 submit submit VB cord-345222-otfnrarh 315 2 your -PRON- PRP$ cord-345222-otfnrarh 315 3 manuscript manuscript NN cord-345222-otfnrarh 315 4 | | POS cord-345222-otfnrarh 315 5 www.dovepress.com www.dovepress.com ADD cord-345222-otfnrarh 316 1 For for IN cord-345222-otfnrarh 316 2 physical physical JJ cord-345222-otfnrarh 316 3 and and CC cord-345222-otfnrarh 316 4 chemical chemical JJ cord-345222-otfnrarh 316 5 study study NN cord-345222-otfnrarh 316 6 of of IN cord-345222-otfnrarh 316 7 feces fece NNS cord-345222-otfnrarh 316 8 , , , cord-345222-otfnrarh 316 9 fecal fecal JJ cord-345222-otfnrarh 316 10 pH ph NN cord-345222-otfnrarh 316 11 less less JJR cord-345222-otfnrarh 316 12 than than IN cord-345222-otfnrarh 316 13 or or CC cord-345222-otfnrarh 316 14 equal equal JJ cord-345222-otfnrarh 316 15 to to IN cord-345222-otfnrarh 316 16 5.5 5.5 CD cord-345222-otfnrarh 316 17 or or CC cord-345222-otfnrarh 316 18 the the DT cord-345222-otfnrarh 316 19 presence presence NN cord-345222-otfnrarh 316 20 of of IN cord-345222-otfnrarh 316 21 reducing reduce VBG cord-345222-otfnrarh 316 22 substances substance NNS cord-345222-otfnrarh 316 23 is be VBZ cord-345222-otfnrarh 316 24 a a DT cord-345222-otfnrarh 316 25 sign sign NN cord-345222-otfnrarh 316 26 of of IN cord-345222-otfnrarh 316 27 intolerance intolerance NN cord-345222-otfnrarh 316 28 to to IN cord-345222-otfnrarh 316 29 carbohydrates carbohydrate NNS cord-345222-otfnrarh 316 30 , , , cord-345222-otfnrarh 316 31 mostly mostly RB cord-345222-otfnrarh 316 32 secondary secondary JJ cord-345222-otfnrarh 316 33 to to IN cord-345222-otfnrarh 316 34 viral viral JJ cord-345222-otfnrarh 316 35 infection infection NN cord-345222-otfnrarh 316 36 . . . cord-345222-otfnrarh 317 1 For for IN cord-345222-otfnrarh 317 2 microscopic microscopic JJ cord-345222-otfnrarh 317 3 examination examination NN cord-345222-otfnrarh 317 4 of of IN cord-345222-otfnrarh 317 5 stool stool NN cord-345222-otfnrarh 317 6 , , , cord-345222-otfnrarh 317 7 the the DT cord-345222-otfnrarh 317 8 presence presence NN cord-345222-otfnrarh 317 9 of of IN cord-345222-otfnrarh 317 10 leukocytes leukocyte NNS cord-345222-otfnrarh 317 11 is be VBZ cord-345222-otfnrarh 317 12 suggestive suggestive JJ cord-345222-otfnrarh 317 13 of of IN cord-345222-otfnrarh 317 14 an an DT cord-345222-otfnrarh 317 15 enteroinvasive enteroinvasive JJ cord-345222-otfnrarh 317 16 infection infection NN cord-345222-otfnrarh 317 17 , , , cord-345222-otfnrarh 317 18 although although IN cord-345222-otfnrarh 317 19 the the DT cord-345222-otfnrarh 317 20 absence absence NN cord-345222-otfnrarh 317 21 of of IN cord-345222-otfnrarh 317 22 leukocytes leukocyte NNS cord-345222-otfnrarh 317 23 can can MD cord-345222-otfnrarh 317 24 not not RB cord-345222-otfnrarh 317 25 exclude exclude VB cord-345222-otfnrarh 317 26 it -PRON- PRP cord-345222-otfnrarh 317 27 . . . cord-345222-otfnrarh 318 1 However however RB cord-345222-otfnrarh 318 2 , , , cord-345222-otfnrarh 318 3 infections infection NNS cord-345222-otfnrarh 318 4 mediated mediate VBN cord-345222-otfnrarh 318 5 by by IN cord-345222-otfnrarh 318 6 enterotoxins enterotoxin NNS cord-345222-otfnrarh 318 7 ( ( -LRB- cord-345222-otfnrarh 318 8 ETEC ETEC NNP cord-345222-otfnrarh 318 9 , , , cord-345222-otfnrarh 318 10 Vibrio Vibrio NNP cord-345222-otfnrarh 318 11 cholerae cholerae NN cord-345222-otfnrarh 318 12 , , , cord-345222-otfnrarh 318 13 and and CC cord-345222-otfnrarh 318 14 viruses virus NNS cord-345222-otfnrarh 318 15 ) ) -RRB- cord-345222-otfnrarh 318 16 have have VBP cord-345222-otfnrarh 318 17 no no DT cord-345222-otfnrarh 318 18 white white JJ cord-345222-otfnrarh 318 19 blood blood NN cord-345222-otfnrarh 318 20 cells cell NNS cord-345222-otfnrarh 318 21 in in IN cord-345222-otfnrarh 318 22 stool stool NN cord-345222-otfnrarh 318 23 . . . cord-345222-otfnrarh 319 1 For for IN cord-345222-otfnrarh 319 2 fecal fecal JJ cord-345222-otfnrarh 319 3 culture culture NN cord-345222-otfnrarh 319 4 , , , cord-345222-otfnrarh 319 5 various various JJ cord-345222-otfnrarh 319 6 culture culture NN cord-345222-otfnrarh 319 7 media medium NNS cord-345222-otfnrarh 319 8 are be VBP cord-345222-otfnrarh 319 9 used use VBN cord-345222-otfnrarh 319 10 to to TO cord-345222-otfnrarh 319 11 isolate isolate VB cord-345222-otfnrarh 319 12 the the DT cord-345222-otfnrarh 319 13 bacteria bacteria NNS cord-345222-otfnrarh 319 14 . . . cord-345222-otfnrarh 320 1 The the DT cord-345222-otfnrarh 320 2 clinical clinical JJ cord-345222-otfnrarh 320 3 history history NN cord-345222-otfnrarh 320 4 , , , cord-345222-otfnrarh 320 5 physicochemical physicochemical JJ cord-345222-otfnrarh 320 6 characteristics characteristic NNS cord-345222-otfnrarh 320 7 of of IN cord-345222-otfnrarh 320 8 the the DT cord-345222-otfnrarh 320 9 stool stool NN cord-345222-otfnrarh 320 10 , , , cord-345222-otfnrarh 320 11 and and CC cord-345222-otfnrarh 320 12 laboratory laboratory NN cord-345222-otfnrarh 320 13 tests test NNS cord-345222-otfnrarh 320 14 thus thus RB cord-345222-otfnrarh 320 15 allow allow VBP cord-345222-otfnrarh 320 16 the the DT cord-345222-otfnrarh 320 17 choice choice NN cord-345222-otfnrarh 320 18 of of IN cord-345222-otfnrarh 320 19 an an DT cord-345222-otfnrarh 320 20 appropriate appropriate JJ cord-345222-otfnrarh 320 21 culture culture NN cord-345222-otfnrarh 320 22 medium medium NN cord-345222-otfnrarh 320 23 . . . cord-345222-otfnrarh 321 1 In in IN cord-345222-otfnrarh 321 2 the the DT cord-345222-otfnrarh 321 3 presence presence NN cord-345222-otfnrarh 321 4 of of IN cord-345222-otfnrarh 321 5 clinical clinical JJ cord-345222-otfnrarh 321 6 signs sign NNS cord-345222-otfnrarh 321 7 and and CC cord-345222-otfnrarh 321 8 leukocytes leukocyte NNS cord-345222-otfnrarh 321 9 in in IN cord-345222-otfnrarh 321 10 the the DT cord-345222-otfnrarh 321 11 stool stool NN cord-345222-otfnrarh 321 12 , , , cord-345222-otfnrarh 321 13 it -PRON- PRP cord-345222-otfnrarh 321 14 is be VBZ cord-345222-otfnrarh 321 15 always always RB cord-345222-otfnrarh 321 16 necessary necessary JJ cord-345222-otfnrarh 321 17 to to TO cord-345222-otfnrarh 321 18 perform perform VB cord-345222-otfnrarh 321 19 culture culture NN cord-345222-otfnrarh 321 20 for for IN cord-345222-otfnrarh 321 21 Salmonella Salmonella NNP cord-345222-otfnrarh 321 22 , , , cord-345222-otfnrarh 321 23 Shigella Shigella NNP cord-345222-otfnrarh 321 24 , , , cord-345222-otfnrarh 321 25 and and CC cord-345222-otfnrarh 321 26 Campylobacter Campylobacter NNP cord-345222-otfnrarh 321 27 . . . cord-345222-otfnrarh 322 1 If if IN cord-345222-otfnrarh 322 2 stool stool NN cord-345222-otfnrarh 322 3 cultures culture NNS cord-345222-otfnrarh 322 4 are be VBP cord-345222-otfnrarh 322 5 not not RB cord-345222-otfnrarh 322 6 performed perform VBN cord-345222-otfnrarh 322 7 within within IN cord-345222-otfnrarh 322 8 2 2 CD cord-345222-otfnrarh 322 9 hours hour NNS cord-345222-otfnrarh 322 10 of of IN cord-345222-otfnrarh 322 11 sample sample NN cord-345222-otfnrarh 322 12 collection collection NN cord-345222-otfnrarh 322 13 , , , cord-345222-otfnrarh 322 14 it -PRON- PRP cord-345222-otfnrarh 322 15 is be VBZ cord-345222-otfnrarh 322 16 necessary necessary JJ cord-345222-otfnrarh 322 17 to to TO cord-345222-otfnrarh 322 18 keep keep VB cord-345222-otfnrarh 322 19 the the DT cord-345222-otfnrarh 322 20 stool stool NN cord-345222-otfnrarh 322 21 at at IN cord-345222-otfnrarh 322 22 4 4 CD cord-345222-otfnrarh 322 23 ° ° NN cord-345222-otfnrarh 322 24 C c NN cord-345222-otfnrarh 322 25 . . . cord-345222-otfnrarh 323 1 Blood blood NN cord-345222-otfnrarh 323 2 cultures culture NNS cord-345222-otfnrarh 323 3 are be VBP cord-345222-otfnrarh 323 4 examined examine VBN cord-345222-otfnrarh 323 5 for for IN cord-345222-otfnrarh 323 6 evidence evidence NN cord-345222-otfnrarh 323 7 of of IN cord-345222-otfnrarh 323 8 bacteremia bacteremia NN cord-345222-otfnrarh 323 9 . . . cord-345222-otfnrarh 324 1 Research research NN cord-345222-otfnrarh 324 2 of of IN cord-345222-otfnrarh 324 3 bacterial bacterial JJ cord-345222-otfnrarh 324 4 toxins toxin NNS cord-345222-otfnrarh 324 5 is be VBZ cord-345222-otfnrarh 324 6 conducted conduct VBN cord-345222-otfnrarh 324 7 through through IN cord-345222-otfnrarh 324 8 enzyme enzyme NN cord-345222-otfnrarh 324 9 - - HYPH cord-345222-otfnrarh 324 10 linked link VBN cord-345222-otfnrarh 324 11 immunosorbent immunosorbent JJ cord-345222-otfnrarh 324 12 assay assay NN cord-345222-otfnrarh 324 13 ( ( -LRB- cord-345222-otfnrarh 324 14 ELISA ELISA NNP cord-345222-otfnrarh 324 15 ) ) -RRB- cord-345222-otfnrarh 324 16 . . . cord-345222-otfnrarh 325 1 42 42 CD cord-345222-otfnrarh 326 1 The the DT cord-345222-otfnrarh 326 2 fecal fecal JJ cord-345222-otfnrarh 326 3 rotavirus rotavirus NN cord-345222-otfnrarh 326 4 antigen antigen NN cord-345222-otfnrarh 326 5 is be VBZ cord-345222-otfnrarh 326 6 examined examine VBN cord-345222-otfnrarh 326 7 through through IN cord-345222-otfnrarh 326 8 ELISA ELISA NNP cord-345222-otfnrarh 326 9 and and CC cord-345222-otfnrarh 326 10 latex latex NN cord-345222-otfnrarh 326 11 agglutination agglutination NN cord-345222-otfnrarh 326 12 test test NN cord-345222-otfnrarh 326 13 ; ; : cord-345222-otfnrarh 326 14 search search NN cord-345222-otfnrarh 326 15 of of IN cord-345222-otfnrarh 326 16 adenovirus adenovirus NN cord-345222-otfnrarh 326 17 fecal fecal JJ cord-345222-otfnrarh 326 18 antigen antigen NN cord-345222-otfnrarh 326 19 is be VBZ cord-345222-otfnrarh 326 20 performed perform VBN cord-345222-otfnrarh 326 21 using use VBG cord-345222-otfnrarh 326 22 ELISA ELISA NNP cord-345222-otfnrarh 326 23 . . . cord-345222-otfnrarh 327 1 98 98 CD cord-345222-otfnrarh 327 2 Polymerase polymerase NN cord-345222-otfnrarh 327 3 chain chain NN cord-345222-otfnrarh 327 4 reaction reaction NN cord-345222-otfnrarh 327 5 ( ( -LRB- cord-345222-otfnrarh 327 6 PCR PCR NNP cord-345222-otfnrarh 327 7 ) ) -RRB- cord-345222-otfnrarh 327 8 or or CC cord-345222-otfnrarh 327 9 other other JJ cord-345222-otfnrarh 327 10 molecular molecular JJ cord-345222-otfnrarh 327 11 investigations investigation NNS cord-345222-otfnrarh 327 12 are be VBP cord-345222-otfnrarh 327 13 performed perform VBN cord-345222-otfnrarh 327 14 for for IN cord-345222-otfnrarh 327 15 viral viral JJ cord-345222-otfnrarh 327 16 research research NN cord-345222-otfnrarh 327 17 , , , cord-345222-otfnrarh 327 18 especially especially RB cord-345222-otfnrarh 327 19 on on IN cord-345222-otfnrarh 327 20 stools stool NNS cord-345222-otfnrarh 327 21 for for IN cord-345222-otfnrarh 327 22 norovirus norovirus NN cord-345222-otfnrarh 327 23 , , , cord-345222-otfnrarh 327 24 adenovirus adenovirus NN cord-345222-otfnrarh 327 25 , , , cord-345222-otfnrarh 327 26 sapovirus sapovirus NNP cord-345222-otfnrarh 327 27 , , , cord-345222-otfnrarh 327 28 and and CC cord-345222-otfnrarh 327 29 human human JJ cord-345222-otfnrarh 327 30 bocavirus bocavirus NN cord-345222-otfnrarh 327 31 , , , cord-345222-otfnrarh 327 32 and and CC cord-345222-otfnrarh 327 33 PCR PCR NNP cord-345222-otfnrarh 327 34 of of IN cord-345222-otfnrarh 327 35 stool stool NN cord-345222-otfnrarh 327 36 and and CC cord-345222-otfnrarh 327 37 blood blood NN cord-345222-otfnrarh 327 38 is be VBZ cord-345222-otfnrarh 327 39 used use VBN cord-345222-otfnrarh 327 40 for for IN cord-345222-otfnrarh 327 41 the the DT cord-345222-otfnrarh 327 42 detection detection NN cord-345222-otfnrarh 327 43 of of IN cord-345222-otfnrarh 327 44 enteroviruses enterovirus NNS cord-345222-otfnrarh 327 45 . . . cord-345222-otfnrarh 328 1 63 63 CD cord-345222-otfnrarh 329 1 A a DT cord-345222-otfnrarh 329 2 Providencia Providencia NNP cord-345222-otfnrarh 329 3 genus genus NN cord-345222-otfnrarh 329 4 - - HYPH cord-345222-otfnrarh 329 5 specific specific JJ cord-345222-otfnrarh 329 6 PCR pcr NN cord-345222-otfnrarh 329 7 method method NN cord-345222-otfnrarh 329 8 has have VBZ cord-345222-otfnrarh 329 9 been be VBN cord-345222-otfnrarh 329 10 developed develop VBN cord-345222-otfnrarh 329 11 , , , cord-345222-otfnrarh 329 12 and and CC cord-345222-otfnrarh 329 13 its -PRON- PRP$ cord-345222-otfnrarh 329 14 specificity specificity NN cord-345222-otfnrarh 329 15 and and CC cord-345222-otfnrarh 329 16 sensitivity sensitivity NN cord-345222-otfnrarh 329 17 was be VBD cord-345222-otfnrarh 329 18 evaluated evaluate VBN cord-345222-otfnrarh 329 19 to to TO cord-345222-otfnrarh 329 20 be be VB cord-345222-otfnrarh 329 21 100 100 CD cord-345222-otfnrarh 329 22 % % NN cord-345222-otfnrarh 329 23 with with IN cord-345222-otfnrarh 329 24 various various JJ cord-345222-otfnrarh 329 25 bacterial bacterial JJ cord-345222-otfnrarh 329 26 strains strain NNS cord-345222-otfnrarh 329 27 . . . cord-345222-otfnrarh 330 1 99 99 CD cord-345222-otfnrarh 331 1 Recently recently RB cord-345222-otfnrarh 331 2 , , , cord-345222-otfnrarh 331 3 PCR PCR NNP cord-345222-otfnrarh 331 4 methods method NNS cord-345222-otfnrarh 331 5 have have VBP cord-345222-otfnrarh 331 6 been be VBN cord-345222-otfnrarh 331 7 applied apply VBN cord-345222-otfnrarh 331 8 to to TO cord-345222-otfnrarh 331 9 investigate investigate VB cord-345222-otfnrarh 331 10 the the DT cord-345222-otfnrarh 331 11 prevalence prevalence NN cord-345222-otfnrarh 331 12 of of IN cord-345222-otfnrarh 331 13 the the DT cord-345222-otfnrarh 331 14 virulence virulence NN cord-345222-otfnrarh 331 15 genes gene NNS cord-345222-otfnrarh 331 16 specific specific JJ cord-345222-otfnrarh 331 17 for for IN cord-345222-otfnrarh 331 18 five five CD cord-345222-otfnrarh 331 19 major major JJ cord-345222-otfnrarh 331 20 pathogroups pathogroup NNS cord-345222-otfnrarh 331 21 of of IN cord-345222-otfnrarh 331 22 diarrheagenic diarrheagenic NNP cord-345222-otfnrarh 331 23 Escherichia Escherichia NNP cord-345222-otfnrarh 331 24 coli coli NNS cord-345222-otfnrarh 331 25 in in IN cord-345222-otfnrarh 331 26 primary primary JJ cord-345222-otfnrarh 331 27 cultures culture NNS cord-345222-otfnrarh 331 28 from from IN cord-345222-otfnrarh 331 29 feces fece NNS cord-345222-otfnrarh 331 30 of of IN cord-345222-otfnrarh 331 31 animals animal NNS cord-345222-otfnrarh 331 32 slaughtered slaughter VBN cord-345222-otfnrarh 331 33 for for IN cord-345222-otfnrarh 331 34 human human JJ cord-345222-otfnrarh 331 35 consumption consumption NN cord-345222-otfnrarh 331 36 in in IN cord-345222-otfnrarh 331 37 Burkina Burkina NNP cord-345222-otfnrarh 331 38 Faso Faso NNP cord-345222-otfnrarh 331 39 that that WDT cord-345222-otfnrarh 331 40 revealed reveal VBD cord-345222-otfnrarh 331 41 the the DT cord-345222-otfnrarh 331 42 common common JJ cord-345222-otfnrarh 331 43 occurrence occurrence NN cord-345222-otfnrarh 331 44 of of IN cord-345222-otfnrarh 331 45 the the DT cord-345222-otfnrarh 331 46 diarrheal diarrheal JJ cord-345222-otfnrarh 331 47 virulence virulence NN cord-345222-otfnrarh 331 48 genes gene NNS cord-345222-otfnrarh 331 49 in in IN cord-345222-otfnrarh 331 50 feces fece NNS cord-345222-otfnrarh 331 51 of of IN cord-345222-otfnrarh 331 52 food food NN cord-345222-otfnrarh 331 53 animals animal NNS cord-345222-otfnrarh 331 54 . . . cord-345222-otfnrarh 332 1 100 100 CD cord-345222-otfnrarh 333 1 Another another DT cord-345222-otfnrarh 333 2 study study NN cord-345222-otfnrarh 333 3 investigated investigate VBD cord-345222-otfnrarh 333 4 using use VBG cord-345222-otfnrarh 333 5 PCR PCR NNP cord-345222-otfnrarh 333 6 for for IN cord-345222-otfnrarh 333 7 the the DT cord-345222-otfnrarh 333 8 incidence incidence NN cord-345222-otfnrarh 333 9 , , , cord-345222-otfnrarh 333 10 antimicrobial antimicrobial JJ cord-345222-otfnrarh 333 11 resistance resistance NN cord-345222-otfnrarh 333 12 , , , cord-345222-otfnrarh 333 13 and and CC cord-345222-otfnrarh 333 14 genetic genetic JJ cord-345222-otfnrarh 333 15 relationships relationship NNS cord-345222-otfnrarh 333 16 of of IN cord-345222-otfnrarh 333 17 EPEC EPEC NNS cord-345222-otfnrarh 333 18 in in IN cord-345222-otfnrarh 333 19 children child NNS cord-345222-otfnrarh 333 20 with with IN cord-345222-otfnrarh 333 21 diarrhea diarrhea NN cord-345222-otfnrarh 333 22 . . . cord-345222-otfnrarh 334 1 101 101 CD cord-345222-otfnrarh 335 1 Regarding regard VBG cord-345222-otfnrarh 335 2 parasitic parasitic JJ cord-345222-otfnrarh 335 3 infection infection NN cord-345222-otfnrarh 335 4 and and CC cord-345222-otfnrarh 335 5 study study NN cord-345222-otfnrarh 335 6 of of IN cord-345222-otfnrarh 335 7 trophozoites trophozoite NNS cord-345222-otfnrarh 335 8 or or CC cord-345222-otfnrarh 335 9 oocysts oocyst NNS cord-345222-otfnrarh 335 10 , , , cord-345222-otfnrarh 335 11 antigen antigen NN cord-345222-otfnrarh 335 12 detection detection NN cord-345222-otfnrarh 335 13 of of IN cord-345222-otfnrarh 335 14 stool stool NN cord-345222-otfnrarh 335 15 through through IN cord-345222-otfnrarh 335 16 ELISA ELISA NNP cord-345222-otfnrarh 335 17 is be VBZ cord-345222-otfnrarh 335 18 used use VBN cord-345222-otfnrarh 335 19 ; ; : cord-345222-otfnrarh 335 20 the the DT cord-345222-otfnrarh 335 21 serological serological JJ cord-345222-otfnrarh 335 22 study study NN cord-345222-otfnrarh 335 23 can can MD cord-345222-otfnrarh 335 24 be be VB cord-345222-otfnrarh 335 25 helpful helpful JJ cord-345222-otfnrarh 335 26 in in IN cord-345222-otfnrarh 335 27 rare rare JJ cord-345222-otfnrarh 335 28 systemic systemic JJ cord-345222-otfnrarh 335 29 infections infection NNS cord-345222-otfnrarh 335 30 . . . cord-345222-otfnrarh 336 1 60 60 CD cord-345222-otfnrarh 336 2 , , , cord-345222-otfnrarh 336 3 82 82 CD cord-345222-otfnrarh 336 4 , , , cord-345222-otfnrarh 336 5 91 91 CD cord-345222-otfnrarh 337 1 For for IN cord-345222-otfnrarh 337 2 intestinal intestinal JJ cord-345222-otfnrarh 337 3 infection infection NN cord-345222-otfnrarh 337 4 by by IN cord-345222-otfnrarh 337 5 enteroinvasive enteroinvasive JJ cord-345222-otfnrarh 337 6 agents agent NNS cord-345222-otfnrarh 337 7 , , , cord-345222-otfnrarh 337 8 it -PRON- PRP cord-345222-otfnrarh 337 9 is be VBZ cord-345222-otfnrarh 337 10 possible possible JJ cord-345222-otfnrarh 337 11 to to TO cord-345222-otfnrarh 337 12 find find VB cord-345222-otfnrarh 337 13 low low JJ cord-345222-otfnrarh 337 14 blood blood NN cord-345222-otfnrarh 337 15 levels level NNS cord-345222-otfnrarh 337 16 of of IN cord-345222-otfnrarh 337 17 albumin albumin NN cord-345222-otfnrarh 337 18 and and CC cord-345222-otfnrarh 337 19 high high JJ cord-345222-otfnrarh 337 20 levels level NNS cord-345222-otfnrarh 337 21 of of IN cord-345222-otfnrarh 337 22 alpha alpha NN cord-345222-otfnrarh 337 23 - - HYPH cord-345222-otfnrarh 337 24 l l NN cord-345222-otfnrarh 337 25 - - HYPH cord-345222-otfnrarh 337 26 antitrypsin antitrypsin NN cord-345222-otfnrarh 337 27 in in IN cord-345222-otfnrarh 337 28 the the DT cord-345222-otfnrarh 337 29 stool stool NN cord-345222-otfnrarh 337 30 , , , cord-345222-otfnrarh 337 31 and and CC cord-345222-otfnrarh 337 32 an an DT cord-345222-otfnrarh 337 33 index index NN cord-345222-otfnrarh 337 34 of of IN cord-345222-otfnrarh 337 35 extended extended JJ cord-345222-otfnrarh 337 36 intestinal intestinal JJ cord-345222-otfnrarh 337 37 inflammation inflammation NN cord-345222-otfnrarh 337 38 with with IN cord-345222-otfnrarh 337 39 dispersion dispersion NN cord-345222-otfnrarh 337 40 of of IN cord-345222-otfnrarh 337 41 proteins protein NNS cord-345222-otfnrarh 337 42 . . . cord-345222-otfnrarh 338 1 22 22 CD cord-345222-otfnrarh 338 2 Parents parent NNS cord-345222-otfnrarh 338 3 , , , cord-345222-otfnrarh 338 4 caregivers caregiver NNS cord-345222-otfnrarh 338 5 , , , cord-345222-otfnrarh 338 6 and and CC cord-345222-otfnrarh 338 7 children child NNS cord-345222-otfnrarh 338 8 should should MD cord-345222-otfnrarh 338 9 be be VB cord-345222-otfnrarh 338 10 informed inform VBN cord-345222-otfnrarh 338 11 that that IN cord-345222-otfnrarh 338 12 it -PRON- PRP cord-345222-otfnrarh 338 13 is be VBZ cord-345222-otfnrarh 338 14 possible possible JJ cord-345222-otfnrarh 338 15 to to TO cord-345222-otfnrarh 338 16 prevent prevent VB cord-345222-otfnrarh 338 17 the the DT cord-345222-otfnrarh 338 18 spread spread NN cord-345222-otfnrarh 338 19 of of IN cord-345222-otfnrarh 338 20 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 338 21 using use VBG cord-345222-otfnrarh 338 22 some some DT cord-345222-otfnrarh 338 23 simple simple JJ cord-345222-otfnrarh 338 24 rules rule NNS cord-345222-otfnrarh 339 1 : : : cord-345222-otfnrarh 339 2 • • NNP cord-345222-otfnrarh 339 3 wash wash VB cord-345222-otfnrarh 339 4 hands hand NNS cord-345222-otfnrarh 339 5 with with IN cord-345222-otfnrarh 339 6 soap soap NN cord-345222-otfnrarh 339 7 and and CC cord-345222-otfnrarh 339 8 water water NN cord-345222-otfnrarh 339 9 , , , cord-345222-otfnrarh 339 10 especially especially RB cord-345222-otfnrarh 339 11 after after IN cord-345222-otfnrarh 339 12 using use VBG cord-345222-otfnrarh 339 13 toilet toilet NN cord-345222-otfnrarh 339 14 or or CC cord-345222-otfnrarh 339 15 changing change VBG cord-345222-otfnrarh 339 16 diapers diaper NNS cord-345222-otfnrarh 339 17 and and CC cord-345222-otfnrarh 339 18 before before IN cord-345222-otfnrarh 339 19 preparing prepare VBG cord-345222-otfnrarh 339 20 , , , cord-345222-otfnrarh 339 21 serving serve VBG cord-345222-otfnrarh 339 22 , , , cord-345222-otfnrarh 339 23 or or CC cord-345222-otfnrarh 339 24 eating eat VBG cord-345222-otfnrarh 339 25 food food NN cord-345222-otfnrarh 340 1 • • NNS cord-345222-otfnrarh 340 2 do do VBP cord-345222-otfnrarh 340 3 not not RB cord-345222-otfnrarh 340 4 share share VB cord-345222-otfnrarh 340 5 towels towel NNS cord-345222-otfnrarh 340 6 used use VBN cord-345222-otfnrarh 340 7 by by IN cord-345222-otfnrarh 340 8 infected infected JJ cord-345222-otfnrarh 340 9 children child NNS cord-345222-otfnrarh 341 1 • • NNS cord-345222-otfnrarh 341 2 children child NNS cord-345222-otfnrarh 341 3 should should MD cord-345222-otfnrarh 341 4 not not RB cord-345222-otfnrarh 341 5 attend attend VB cord-345222-otfnrarh 341 6 any any DT cord-345222-otfnrarh 341 7 school school NN cord-345222-otfnrarh 341 8 or or CC cord-345222-otfnrarh 341 9 other other JJ cord-345222-otfnrarh 341 10 child child NN cord-345222-otfnrarh 341 11 - - HYPH cord-345222-otfnrarh 341 12 care care NN cord-345222-otfnrarh 341 13 facility facility NN cord-345222-otfnrarh 341 14 while while IN cord-345222-otfnrarh 341 15 they -PRON- PRP cord-345222-otfnrarh 341 16 have have VBP cord-345222-otfnrarh 341 17 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 341 18 ; ; : cord-345222-otfnrarh 341 19 they -PRON- PRP cord-345222-otfnrarh 341 20 can can MD cord-345222-otfnrarh 341 21 go go VB cord-345222-otfnrarh 341 22 back back RB cord-345222-otfnrarh 341 23 to to IN cord-345222-otfnrarh 341 24 school school NN cord-345222-otfnrarh 341 25 from from IN cord-345222-otfnrarh 341 26 at at RB cord-345222-otfnrarh 341 27 least least RBS cord-345222-otfnrarh 341 28 48 48 CD cord-345222-otfnrarh 341 29 hours hour NNS cord-345222-otfnrarh 341 30 after after IN cord-345222-otfnrarh 341 31 the the DT cord-345222-otfnrarh 341 32 last last JJ cord-345222-otfnrarh 341 33 episode episode NN cord-345222-otfnrarh 341 34 of of IN cord-345222-otfnrarh 341 35 diarrhea diarrhea NN cord-345222-otfnrarh 341 36 or or CC cord-345222-otfnrarh 341 37 vomiting vomit VBG cord-345222-otfnrarh 342 1 • • NNS cord-345222-otfnrarh 342 2 children child NNS cord-345222-otfnrarh 342 3 should should MD cord-345222-otfnrarh 342 4 not not RB cord-345222-otfnrarh 342 5 use use VB cord-345222-otfnrarh 342 6 swimming swimming NN cord-345222-otfnrarh 342 7 pools pool NNS cord-345222-otfnrarh 342 8 for for IN cord-345222-otfnrarh 342 9 2 2 CD cord-345222-otfnrarh 342 10 weeks week NNS cord-345222-otfnrarh 342 11 after after IN cord-345222-otfnrarh 342 12 the the DT cord-345222-otfnrarh 342 13 last last JJ cord-345222-otfnrarh 342 14 episode episode NN cord-345222-otfnrarh 342 15 of of IN cord-345222-otfnrarh 342 16 diarrhea diarrhea NN cord-345222-otfnrarh 342 17 102,103 102,103 CD cord-345222-otfnrarh 343 1 • • NNP cord-345222-otfnrarh 343 2 implementing implement VBG cord-345222-otfnrarh 343 3 rotavirus rotavirus JJ cord-345222-otfnrarh 343 4 vaccination vaccination NN cord-345222-otfnrarh 343 5 : : : cord-345222-otfnrarh 343 6 the the DT cord-345222-otfnrarh 343 7 new new JJ cord-345222-otfnrarh 343 8 rotavirus rotavirus JJ cord-345222-otfnrarh 343 9 vaccines vaccine NNS cord-345222-otfnrarh 343 10 are be VBP cord-345222-otfnrarh 343 11 safe safe JJ cord-345222-otfnrarh 343 12 and and CC cord-345222-otfnrarh 343 13 reduce reduce VB cord-345222-otfnrarh 343 14 the the DT cord-345222-otfnrarh 343 15 severity severity NN cord-345222-otfnrarh 343 16 of of IN cord-345222-otfnrarh 343 17 infection infection NN cord-345222-otfnrarh 343 18 and and CC cord-345222-otfnrarh 343 19 prevent prevent VB cord-345222-otfnrarh 343 20 deaths death NNS cord-345222-otfnrarh 343 21 , , , cord-345222-otfnrarh 343 22 but but CC cord-345222-otfnrarh 343 23 they -PRON- PRP cord-345222-otfnrarh 343 24 do do VBP cord-345222-otfnrarh 343 25 not not RB cord-345222-otfnrarh 343 26 prevent prevent VB cord-345222-otfnrarh 343 27 all all DT cord-345222-otfnrarh 343 28 cases case NNS cord-345222-otfnrarh 343 29 of of IN cord-345222-otfnrarh 343 30 rotavirus rotavirus JJ cord-345222-otfnrarh 343 31 diarrhea diarrhea NN cord-345222-otfnrarh 343 32 . . . cord-345222-otfnrarh 344 1 104 104 CD cord-345222-otfnrarh 345 1 Two two CD cord-345222-otfnrarh 345 2 live live JJ cord-345222-otfnrarh 345 3 , , , cord-345222-otfnrarh 345 4 oral oral JJ cord-345222-otfnrarh 345 5 , , , cord-345222-otfnrarh 345 6 attenuated attenuated JJ cord-345222-otfnrarh 345 7 rotavirus rotavirus JJ cord-345222-otfnrarh 345 8 vaccines vaccine NNS cord-345222-otfnrarh 345 9 were be VBD cord-345222-otfnrarh 345 10 licensed license VBN cord-345222-otfnrarh 345 11 in in IN cord-345222-otfnrarh 345 12 2006 2006 CD cord-345222-otfnrarh 345 13 : : : cord-345222-otfnrarh 345 14 a a DT cord-345222-otfnrarh 345 15 pentavalent pentavalent JJ cord-345222-otfnrarh 345 16 bovine bovine JJ cord-345222-otfnrarh 345 17 - - HYPH cord-345222-otfnrarh 345 18 human human JJ cord-345222-otfnrarh 345 19 recombinant recombinant JJ cord-345222-otfnrarh 345 20 vaccine vaccine NN cord-345222-otfnrarh 345 21 and and CC cord-345222-otfnrarh 345 22 a a DT cord-345222-otfnrarh 345 23 monovalent monovalent JJ cord-345222-otfnrarh 345 24 human human JJ cord-345222-otfnrarh 345 25 rotavirus rotavirus JJ cord-345222-otfnrarh 345 26 vaccine vaccine NN cord-345222-otfnrarh 345 27 . . . cord-345222-otfnrarh 346 1 Both both DT cord-345222-otfnrarh 346 2 vaccines vaccine NNS cord-345222-otfnrarh 346 3 have have VBP cord-345222-otfnrarh 346 4 demonstrated demonstrate VBN cord-345222-otfnrarh 346 5 good good JJ cord-345222-otfnrarh 346 6 safety safety NN cord-345222-otfnrarh 346 7 and and CC cord-345222-otfnrarh 346 8 efficacy efficacy NN cord-345222-otfnrarh 346 9 profiles profile NNS cord-345222-otfnrarh 346 10 in in IN cord-345222-otfnrarh 346 11 large large JJ cord-345222-otfnrarh 346 12 clinical clinical JJ cord-345222-otfnrarh 346 13 trials trial NNS cord-345222-otfnrarh 346 14 in in IN cord-345222-otfnrarh 346 15 resource resource NN cord-345222-otfnrarh 346 16 - - HYPH cord-345222-otfnrarh 346 17 rich rich JJ cord-345222-otfnrarh 346 18 countries country NNS cord-345222-otfnrarh 346 19 and and CC cord-345222-otfnrarh 346 20 in in IN cord-345222-otfnrarh 346 21 Latin Latin NNP cord-345222-otfnrarh 346 22 America America NNP cord-345222-otfnrarh 346 23 . . . cord-345222-otfnrarh 347 1 105 105 CD cord-345222-otfnrarh 347 2 , , , cord-345222-otfnrarh 347 3 106 106 CD cord-345222-otfnrarh 347 4 Immunization Immunization NNP cord-345222-otfnrarh 347 5 against against IN cord-345222-otfnrarh 347 6 rotavirus rotavirus NN cord-345222-otfnrarh 347 7 is be VBZ cord-345222-otfnrarh 347 8 recommended recommend VBN cord-345222-otfnrarh 347 9 in in IN cord-345222-otfnrarh 347 10 Europe Europe NNP cord-345222-otfnrarh 347 11 and and CC cord-345222-otfnrarh 347 12 the the DT cord-345222-otfnrarh 347 13 US US NNP cord-345222-otfnrarh 347 14 . . . cord-345222-otfnrarh 348 1 107 107 CD cord-345222-otfnrarh 348 2 , , , cord-345222-otfnrarh 348 3 108 108 CD cord-345222-otfnrarh 348 4 The the DT cord-345222-otfnrarh 348 5 protective protective JJ cord-345222-otfnrarh 348 6 effects effect NNS cord-345222-otfnrarh 348 7 of of IN cord-345222-otfnrarh 348 8 breastfeeding breastfeed VBG cord-345222-otfnrarh 348 9 against against IN cord-345222-otfnrarh 348 10 gastroenteritis gastroenteritis JJ cord-345222-otfnrarh 348 11 infections infection NNS cord-345222-otfnrarh 348 12 have have VBP cord-345222-otfnrarh 348 13 been be VBN cord-345222-otfnrarh 348 14 demonstrated demonstrate VBN cord-345222-otfnrarh 348 15 in in IN cord-345222-otfnrarh 348 16 several several JJ cord-345222-otfnrarh 348 17 studies study NNS cord-345222-otfnrarh 348 18 . . . cord-345222-otfnrarh 349 1 109 109 CD cord-345222-otfnrarh 349 2 , , , cord-345222-otfnrarh 349 3 110 110 CD cord-345222-otfnrarh 349 4 Antibacterial antibacterial JJ cord-345222-otfnrarh 349 5 substances substance NNS cord-345222-otfnrarh 349 6 , , , cord-345222-otfnrarh 349 7 such such JJ cord-345222-otfnrarh 349 8 as as IN cord-345222-otfnrarh 349 9 lactoferrin lactoferrin NNP cord-345222-otfnrarh 349 10 , , , cord-345222-otfnrarh 349 11 lysozyme lysozyme NNS cord-345222-otfnrarh 349 12 , , , cord-345222-otfnrarh 349 13 phagocytes phagocyte NNS cord-345222-otfnrarh 349 14 , , , cord-345222-otfnrarh 349 15 and and CC cord-345222-otfnrarh 349 16 specific specific JJ cord-345222-otfnrarh 349 17 secretory secretory JJ cord-345222-otfnrarh 349 18 immunoglobulins immunoglobulin NNS cord-345222-otfnrarh 349 19 plays play VBZ cord-345222-otfnrarh 349 20 a a DT cord-345222-otfnrarh 349 21 protective protective JJ cord-345222-otfnrarh 349 22 role role NN cord-345222-otfnrarh 349 23 . . . cord-345222-otfnrarh 350 1 111 111 CD cord-345222-otfnrarh 351 1 The the DT cord-345222-otfnrarh 351 2 ligand ligand NN cord-345222-otfnrarh 351 3 - - HYPH cord-345222-otfnrarh 351 4 specific specific JJ cord-345222-otfnrarh 351 5 action action NN cord-345222-otfnrarh 351 6 of of IN cord-345222-otfnrarh 351 7 κ κ NN cord-345222-otfnrarh 351 8 - - HYPH cord-345222-otfnrarh 351 9 casein casein NN cord-345222-otfnrarh 351 10 inhibits inhibit VBZ cord-345222-otfnrarh 351 11 Helicobacter helicobacter NN cord-345222-otfnrarh 351 12 pylori pylori NN cord-345222-otfnrarh 351 13 adherence adherence NN cord-345222-otfnrarh 351 14 to to IN cord-345222-otfnrarh 351 15 the the DT cord-345222-otfnrarh 351 16 gastric gastric JJ cord-345222-otfnrarh 351 17 mucosa mucosa NN cord-345222-otfnrarh 351 18 . . . cord-345222-otfnrarh 352 1 Human human JJ cord-345222-otfnrarh 352 2 milk milk NN cord-345222-otfnrarh 352 3 also also RB cord-345222-otfnrarh 352 4 has have VBZ cord-345222-otfnrarh 352 5 antiviral antiviral JJ cord-345222-otfnrarh 352 6 action action NN cord-345222-otfnrarh 352 7 through through IN cord-345222-otfnrarh 352 8 the the DT cord-345222-otfnrarh 352 9 lactoferrin lactoferrin NNP cord-345222-otfnrarh 352 10 and and CC cord-345222-otfnrarh 352 11 products product NNS cord-345222-otfnrarh 352 12 of of IN cord-345222-otfnrarh 352 13 digestion digestion NN cord-345222-otfnrarh 352 14 of of IN cord-345222-otfnrarh 352 15 lactoferrin lactoferrin NN cord-345222-otfnrarh 352 16 and and CC cord-345222-otfnrarh 352 17 milk milk NN cord-345222-otfnrarh 352 18 fatty fatty JJ cord-345222-otfnrarh 352 19 acids acid NNS cord-345222-otfnrarh 352 20 . . . cord-345222-otfnrarh 353 1 112 112 CD cord-345222-otfnrarh 354 1 All all DT cord-345222-otfnrarh 354 2 of of IN cord-345222-otfnrarh 354 3 these these DT cord-345222-otfnrarh 354 4 elements element NNS cord-345222-otfnrarh 354 5 suggest suggest VBP cord-345222-otfnrarh 354 6 that that IN cord-345222-otfnrarh 354 7 exclusive exclusive JJ cord-345222-otfnrarh 354 8 breastfeeding breastfeeding NN cord-345222-otfnrarh 354 9 contributes contribute VBZ cord-345222-otfnrarh 354 10 to to IN cord-345222-otfnrarh 354 11 protection protection NN cord-345222-otfnrarh 354 12 against against IN cord-345222-otfnrarh 354 13 common common JJ cord-345222-otfnrarh 354 14 infections infection NNS cord-345222-otfnrarh 354 15 during during IN cord-345222-otfnrarh 354 16 infancy infancy NN cord-345222-otfnrarh 354 17 and and CC cord-345222-otfnrarh 354 18 lessens lessen VBZ cord-345222-otfnrarh 354 19 the the DT cord-345222-otfnrarh 354 20 frequency frequency NN cord-345222-otfnrarh 354 21 and and CC cord-345222-otfnrarh 354 22 severity severity NN cord-345222-otfnrarh 354 23 of of IN cord-345222-otfnrarh 354 24 infectious infectious JJ cord-345222-otfnrarh 354 25 episodes episode NNS cord-345222-otfnrarh 354 26 . . . cord-345222-otfnrarh 355 1 113 113 CD cord-345222-otfnrarh 356 1 Breastfeeding breastfeeding NN cord-345222-otfnrarh 356 2 promotes promote VBZ cord-345222-otfnrarh 356 3 the the DT cord-345222-otfnrarh 356 4 colonization colonization NN cord-345222-otfnrarh 356 5 of of IN cord-345222-otfnrarh 356 6 the the DT cord-345222-otfnrarh 356 7 intestinal intestinal JJ cord-345222-otfnrarh 356 8 ecosystem ecosystem NN cord-345222-otfnrarh 356 9 with with IN cord-345222-otfnrarh 356 10 a a DT cord-345222-otfnrarh 356 11 predominance predominance NN cord-345222-otfnrarh 356 12 of of IN cord-345222-otfnrarh 356 13 bifidobacteria bifidobacteria NNP cord-345222-otfnrarh 356 14 and and CC cord-345222-otfnrarh 356 15 lactobacilli lactobacilli NNPS cord-345222-otfnrarh 356 16 ( ( -LRB- cord-345222-otfnrarh 356 17 probiotics probiotic NNS cord-345222-otfnrarh 356 18 ) ) -RRB- cord-345222-otfnrarh 356 19 rather rather RB cord-345222-otfnrarh 356 20 than than IN cord-345222-otfnrarh 356 21 coliforms coliform NNS cord-345222-otfnrarh 356 22 , , , cord-345222-otfnrarh 356 23 enterococci enterococci NNP cord-345222-otfnrarh 356 24 , , , cord-345222-otfnrarh 356 25 and and CC cord-345222-otfnrarh 356 26 bacteroides bacteroides NNP cord-345222-otfnrarh 356 27 that that WDT cord-345222-otfnrarh 356 28 characterize characterize VBP cord-345222-otfnrarh 356 29 the the DT cord-345222-otfnrarh 356 30 intestinal intestinal JJ cord-345222-otfnrarh 356 31 microflora microflora NN cord-345222-otfnrarh 356 32 of of IN cord-345222-otfnrarh 356 33 infants infant NNS cord-345222-otfnrarh 356 34 fed feed VBN cord-345222-otfnrarh 356 35 with with IN cord-345222-otfnrarh 356 36 formula formula NN cord-345222-otfnrarh 356 37 . . . cord-345222-otfnrarh 357 1 114 114 CD cord-345222-otfnrarh 358 1 Some some DT cord-345222-otfnrarh 358 2 authors author NNS cord-345222-otfnrarh 358 3 have have VBP cord-345222-otfnrarh 358 4 demonstrated demonstrate VBN cord-345222-otfnrarh 358 5 that that IN cord-345222-otfnrarh 358 6 the the DT cord-345222-otfnrarh 358 7 use use NN cord-345222-otfnrarh 358 8 of of IN cord-345222-otfnrarh 358 9 formulas formula NNS cord-345222-otfnrarh 358 10 supplemented supplement VBN cord-345222-otfnrarh 358 11 with with IN cord-345222-otfnrarh 358 12 probiotics probiotic NNS cord-345222-otfnrarh 358 13 ( ( -LRB- cord-345222-otfnrarh 358 14 Bifidobacterium bifidobacterium NN cord-345222-otfnrarh 358 15 lactis lactis NN cord-345222-otfnrarh 358 16 and and CC cord-345222-otfnrarh 358 17 Lactobacillus Lactobacillus NNP cord-345222-otfnrarh 358 18 GG GG NNP cord-345222-otfnrarh 358 19 ) ) -RRB- cord-345222-otfnrarh 358 20 have have VBP cord-345222-otfnrarh 358 21 decreased decrease VBN cord-345222-otfnrarh 358 22 the the DT cord-345222-otfnrarh 358 23 incidence incidence NN cord-345222-otfnrarh 358 24 ( ( -LRB- cord-345222-otfnrarh 358 25 up up IN cord-345222-otfnrarh 358 26 to to TO cord-345222-otfnrarh 358 27 57 57 CD cord-345222-otfnrarh 358 28 % % NN cord-345222-otfnrarh 358 29 ) ) -RRB- cord-345222-otfnrarh 358 30 and and CC cord-345222-otfnrarh 358 31 severity severity NN cord-345222-otfnrarh 358 32 of of IN cord-345222-otfnrarh 358 33 diarrhea diarrhea NN cord-345222-otfnrarh 358 34 . . . cord-345222-otfnrarh 359 1 The the DT cord-345222-otfnrarh 359 2 probiotics probiotic NNS cord-345222-otfnrarh 359 3 , , , cord-345222-otfnrarh 359 4 also also RB cord-345222-otfnrarh 359 5 submit submit VB cord-345222-otfnrarh 359 6 your -PRON- PRP$ cord-345222-otfnrarh 359 7 manuscript manuscript NN cord-345222-otfnrarh 359 8 | | POS cord-345222-otfnrarh 359 9 www.dovepress.com www.dovepress.com ADD cord-345222-otfnrarh 360 1 Dovepress Dovepress NNP cord-345222-otfnrarh 360 2 Dovepress Dovepress NNP cord-345222-otfnrarh 360 3 defined define VBN cord-345222-otfnrarh 360 4 as as IN cord-345222-otfnrarh 360 5 food food NN cord-345222-otfnrarh 360 6 supplements supplement NNS cord-345222-otfnrarh 360 7 , , , cord-345222-otfnrarh 360 8 improve improve VB cord-345222-otfnrarh 360 9 intestinal intestinal JJ cord-345222-otfnrarh 360 10 balance balance NN cord-345222-otfnrarh 360 11 , , , cord-345222-otfnrarh 360 12 have have VBP cord-345222-otfnrarh 360 13 beneficial beneficial JJ cord-345222-otfnrarh 360 14 effects effect NNS cord-345222-otfnrarh 360 15 on on IN cord-345222-otfnrarh 360 16 health health NN cord-345222-otfnrarh 360 17 , , , cord-345222-otfnrarh 360 18 and and CC cord-345222-otfnrarh 360 19 are be VBP cord-345222-otfnrarh 360 20 able able JJ cord-345222-otfnrarh 360 21 to to TO cord-345222-otfnrarh 360 22 balance balance VB cord-345222-otfnrarh 360 23 the the DT cord-345222-otfnrarh 360 24 intestinal intestinal JJ cord-345222-otfnrarh 360 25 ecosystem ecosystem NN cord-345222-otfnrarh 360 26 and and CC cord-345222-otfnrarh 360 27 reduce reduce VB cord-345222-otfnrarh 360 28 the the DT cord-345222-otfnrarh 360 29 duration duration NN cord-345222-otfnrarh 360 30 and and CC cord-345222-otfnrarh 360 31 severity severity NN cord-345222-otfnrarh 360 32 of of IN cord-345222-otfnrarh 360 33 diarrheal diarrheal JJ cord-345222-otfnrarh 360 34 infections infection NNS cord-345222-otfnrarh 360 35 , , , cord-345222-otfnrarh 360 36 especially especially RB cord-345222-otfnrarh 360 37 in in IN cord-345222-otfnrarh 360 38 the the DT cord-345222-otfnrarh 360 39 course course NN cord-345222-otfnrarh 360 40 of of IN cord-345222-otfnrarh 360 41 rotavirus rotavirus JJ cord-345222-otfnrarh 360 42 infections infection NNS cord-345222-otfnrarh 360 43 . . . cord-345222-otfnrarh 361 1 The the DT cord-345222-otfnrarh 361 2 probiotics probiotic NNS cord-345222-otfnrarh 361 3 in in IN cord-345222-otfnrarh 361 4 the the DT cord-345222-otfnrarh 361 5 intestine intestine NN cord-345222-otfnrarh 361 6 determine determine NN cord-345222-otfnrarh 361 7 resistance resistance NN cord-345222-otfnrarh 361 8 to to IN cord-345222-otfnrarh 361 9 colonization colonization NN cord-345222-otfnrarh 361 10 by by IN cord-345222-otfnrarh 361 11 other other JJ cord-345222-otfnrarh 361 12 potentially potentially RB cord-345222-otfnrarh 361 13 pathogenic pathogenic JJ cord-345222-otfnrarh 361 14 microbes microbe NNS cord-345222-otfnrarh 361 15 through through IN cord-345222-otfnrarh 361 16 mechanisms mechanism NNS cord-345222-otfnrarh 361 17 of of IN cord-345222-otfnrarh 361 18 competition competition NN cord-345222-otfnrarh 361 19 or or CC cord-345222-otfnrarh 361 20 inhibition inhibition NN cord-345222-otfnrarh 361 21 , , , cord-345222-otfnrarh 361 22 and and CC cord-345222-otfnrarh 361 23 the the DT cord-345222-otfnrarh 361 24 effects effect NNS cord-345222-otfnrarh 361 25 are be VBP cord-345222-otfnrarh 361 26 expressed express VBN cord-345222-otfnrarh 361 27 both both CC cord-345222-otfnrarh 361 28 on on IN cord-345222-otfnrarh 361 29 nonspecific nonspecific JJ cord-345222-otfnrarh 361 30 innate innate NN cord-345222-otfnrarh 361 31 and and CC cord-345222-otfnrarh 361 32 acquired acquire VBN cord-345222-otfnrarh 361 33 immunity immunity NN cord-345222-otfnrarh 361 34 . . . cord-345222-otfnrarh 362 1 115 115 CD cord-345222-otfnrarh 362 2 Lactobacillus lactobacillus NN cord-345222-otfnrarh 362 3 rhamnosus rhamnosus NN cord-345222-otfnrarh 362 4 GG GG NNP cord-345222-otfnrarh 362 5 ( ( -LRB- cord-345222-otfnrarh 362 6 LGG LGG NNP cord-345222-otfnrarh 362 7 ) ) -RRB- cord-345222-otfnrarh 362 8 is be VBZ cord-345222-otfnrarh 362 9 considered consider VBN cord-345222-otfnrarh 362 10 particularly particularly RB cord-345222-otfnrarh 362 11 effective effective JJ cord-345222-otfnrarh 362 12 in in IN cord-345222-otfnrarh 362 13 the the DT cord-345222-otfnrarh 362 14 management management NN cord-345222-otfnrarh 362 15 of of IN cord-345222-otfnrarh 362 16 AGE AGE NNP cord-345222-otfnrarh 362 17 ; ; : cord-345222-otfnrarh 362 18 this this DT cord-345222-otfnrarh 362 19 is be VBZ cord-345222-otfnrarh 362 20 confirmed confirm VBN cord-345222-otfnrarh 362 21 by by IN cord-345222-otfnrarh 362 22 a a DT cord-345222-otfnrarh 362 23 recent recent JJ cord-345222-otfnrarh 362 24 Cochrane Cochrane NNP cord-345222-otfnrarh 362 25 review review NN cord-345222-otfnrarh 362 26 documenting document VBG cord-345222-otfnrarh 362 27 that that IN cord-345222-otfnrarh 362 28 LGG LGG NNP cord-345222-otfnrarh 362 29 reduced reduce VBD cord-345222-otfnrarh 362 30 the the DT cord-345222-otfnrarh 362 31 duration duration NN cord-345222-otfnrarh 362 32 of of IN cord-345222-otfnrarh 362 33 diarrhea diarrhea NN cord-345222-otfnrarh 362 34 , , , cord-345222-otfnrarh 362 35 mean mean VB cord-345222-otfnrarh 362 36 stool stool NN cord-345222-otfnrarh 362 37 frequency frequency NN cord-345222-otfnrarh 362 38 on on IN cord-345222-otfnrarh 362 39 day day NN cord-345222-otfnrarh 362 40 2 2 CD cord-345222-otfnrarh 362 41 , , , cord-345222-otfnrarh 362 42 and and CC cord-345222-otfnrarh 362 43 the the DT cord-345222-otfnrarh 362 44 risk risk NN cord-345222-otfnrarh 362 45 of of IN cord-345222-otfnrarh 362 46 diarrhea diarrhea NN cord-345222-otfnrarh 362 47 lasting last VBG cord-345222-otfnrarh 362 48 $ $ $ cord-345222-otfnrarh 362 49 4 4 CD cord-345222-otfnrarh 362 50 days day NNS cord-345222-otfnrarh 362 51 . . . cord-345222-otfnrarh 363 1 1 1 CD cord-345222-otfnrarh 363 2 , , , cord-345222-otfnrarh 363 3 116 116 CD cord-345222-otfnrarh 364 1 According accord VBG cord-345222-otfnrarh 364 2 to to IN cord-345222-otfnrarh 364 3 a a DT cord-345222-otfnrarh 364 4 recent recent JJ cord-345222-otfnrarh 364 5 Cochrane Cochrane NNP cord-345222-otfnrarh 364 6 review review NN cord-345222-otfnrarh 364 7 , , , cord-345222-otfnrarh 364 8 Saccharomyces Saccharomyces NNP cord-345222-otfnrarh 364 9 boulardii boulardii NNP cord-345222-otfnrarh 364 10 reduces reduce VBZ cord-345222-otfnrarh 364 11 the the DT cord-345222-otfnrarh 364 12 risk risk NN cord-345222-otfnrarh 364 13 of of IN cord-345222-otfnrarh 364 14 diarrhea diarrhea NN cord-345222-otfnrarh 364 15 lasting last VBG cord-345222-otfnrarh 364 16 $ $ $ cord-345222-otfnrarh 364 17 4 4 CD cord-345222-otfnrarh 364 18 days day NNS cord-345222-otfnrarh 364 19 , , , cord-345222-otfnrarh 364 20 and and CC cord-345222-otfnrarh 365 1 a a DT cord-345222-otfnrarh 365 2 more more RBR cord-345222-otfnrarh 365 3 recent recent JJ cord-345222-otfnrarh 365 4 review review NN cord-345222-otfnrarh 365 5 confirmed confirm VBD cord-345222-otfnrarh 365 6 that that IN cord-345222-otfnrarh 365 7 S. S. NNP cord-345222-otfnrarh 365 8 boulardii boulardii NNP cord-345222-otfnrarh 365 9 significantly significantly RB cord-345222-otfnrarh 365 10 reduced reduce VBD cord-345222-otfnrarh 365 11 the the DT cord-345222-otfnrarh 365 12 duration duration NN cord-345222-otfnrarh 365 13 of of IN cord-345222-otfnrarh 365 14 diarrhea diarrhea NN cord-345222-otfnrarh 365 15 and and CC cord-345222-otfnrarh 365 16 hospitalization hospitalization NN cord-345222-otfnrarh 365 17 . . . cord-345222-otfnrarh 366 1 A a DT cord-345222-otfnrarh 366 2 recent recent JJ cord-345222-otfnrarh 366 3 randomized randomize VBN cord-345222-otfnrarh 366 4 controlled control VBN cord-345222-otfnrarh 366 5 trial trial NN cord-345222-otfnrarh 366 6 evaluated evaluate VBD cord-345222-otfnrarh 366 7 the the DT cord-345222-otfnrarh 366 8 efficacy efficacy NN cord-345222-otfnrarh 366 9 of of IN cord-345222-otfnrarh 366 10 treatment treatment NN cord-345222-otfnrarh 366 11 with with IN cord-345222-otfnrarh 366 12 Lactobacillus lactobacillus NN cord-345222-otfnrarh 366 13 reuteri reuteri NN cord-345222-otfnrarh 366 14 DSM DSM NNP cord-345222-otfnrarh 366 15 17938 17938 CD cord-345222-otfnrarh 366 16 compared compare VBN cord-345222-otfnrarh 366 17 with with IN cord-345222-otfnrarh 366 18 placebo placebo NN cord-345222-otfnrarh 366 19 : : : cord-345222-otfnrarh 366 20 the the DT cord-345222-otfnrarh 366 21 administration administration NN cord-345222-otfnrarh 366 22 of of IN cord-345222-otfnrarh 366 23 L. L. NNP cord-345222-otfnrarh 366 24 reuteri reuteri NNP cord-345222-otfnrarh 366 25 reduced reduce VBD cord-345222-otfnrarh 366 26 the the DT cord-345222-otfnrarh 366 27 duration duration NN cord-345222-otfnrarh 366 28 of of IN cord-345222-otfnrarh 366 29 watery watery JJ cord-345222-otfnrarh 366 30 diarrhea diarrhea NN cord-345222-otfnrarh 366 31 , , , cord-345222-otfnrarh 366 32 the the DT cord-345222-otfnrarh 366 33 risk risk NN cord-345222-otfnrarh 366 34 of of IN cord-345222-otfnrarh 366 35 diarrhea diarrhea NN cord-345222-otfnrarh 366 36 on on IN cord-345222-otfnrarh 366 37 days day NNS cord-345222-otfnrarh 366 38 2 2 CD cord-345222-otfnrarh 366 39 and and CC cord-345222-otfnrarh 366 40 3 3 CD cord-345222-otfnrarh 366 41 , , , cord-345222-otfnrarh 366 42 and and CC cord-345222-otfnrarh 366 43 the the DT cord-345222-otfnrarh 366 44 relapse relapse NN cord-345222-otfnrarh 366 45 rate rate NN cord-345222-otfnrarh 366 46 of of IN cord-345222-otfnrarh 366 47 diarrhea diarrhea NN cord-345222-otfnrarh 366 48 . . . cord-345222-otfnrarh 367 1 1 1 LS cord-345222-otfnrarh 368 1 It -PRON- PRP cord-345222-otfnrarh 368 2 has have VBZ cord-345222-otfnrarh 368 3 been be VBN cord-345222-otfnrarh 368 4 suggested suggest VBN cord-345222-otfnrarh 368 5 that that IN cord-345222-otfnrarh 368 6 probiotics probiotic NNS cord-345222-otfnrarh 368 7 may may MD cord-345222-otfnrarh 368 8 decrease decrease VB cord-345222-otfnrarh 368 9 infant infant NN cord-345222-otfnrarh 368 10 mortality mortality NN cord-345222-otfnrarh 368 11 and and CC cord-345222-otfnrarh 368 12 nosocomial nosocomial JJ cord-345222-otfnrarh 368 13 infections infection NNS cord-345222-otfnrarh 368 14 because because IN cord-345222-otfnrarh 368 15 of of IN cord-345222-otfnrarh 368 16 their -PRON- PRP$ cord-345222-otfnrarh 368 17 ability ability NN cord-345222-otfnrarh 368 18 to to TO cord-345222-otfnrarh 368 19 suppress suppress VB cord-345222-otfnrarh 368 20 colonization colonization NN cord-345222-otfnrarh 368 21 and and CC cord-345222-otfnrarh 368 22 translocation translocation NN cord-345222-otfnrarh 368 23 of of IN cord-345222-otfnrarh 368 24 bacterial bacterial JJ cord-345222-otfnrarh 368 25 pathogens pathogen NNS cord-345222-otfnrarh 368 26 in in IN cord-345222-otfnrarh 368 27 the the DT cord-345222-otfnrarh 368 28 gastrointestinal gastrointestinal JJ cord-345222-otfnrarh 368 29 tract tract NN cord-345222-otfnrarh 368 30 . . . cord-345222-otfnrarh 369 1 Several several JJ cord-345222-otfnrarh 369 2 meta meta JJ cord-345222-otfnrarh 369 3 - - HYPH cord-345222-otfnrarh 369 4 analyses analysis NNS cord-345222-otfnrarh 369 5 evaluating evaluate VBG cord-345222-otfnrarh 369 6 probiotics probiotic NNS cord-345222-otfnrarh 369 7 in in IN cord-345222-otfnrarh 369 8 preterm preterm JJ cord-345222-otfnrarh 369 9 infants infant NNS cord-345222-otfnrarh 369 10 suggest suggest VBP cord-345222-otfnrarh 369 11 a a DT cord-345222-otfnrarh 369 12 beneficial beneficial JJ cord-345222-otfnrarh 369 13 effect effect NN cord-345222-otfnrarh 369 14 for for IN cord-345222-otfnrarh 369 15 the the DT cord-345222-otfnrarh 369 16 prevention prevention NN cord-345222-otfnrarh 369 17 of of IN cord-345222-otfnrarh 369 18 necrotizing necrotize VBG cord-345222-otfnrarh 369 19 enterocolitis enterocolitis NN cord-345222-otfnrarh 369 20 and and CC cord-345222-otfnrarh 369 21 death death NN cord-345222-otfnrarh 369 22 , , , cord-345222-otfnrarh 369 23 but but CC cord-345222-otfnrarh 369 24 less less JJR cord-345222-otfnrarh 369 25 for for IN cord-345222-otfnrarh 369 26 nosocomial nosocomial JJ cord-345222-otfnrarh 369 27 infection infection NN cord-345222-otfnrarh 369 28 . . . cord-345222-otfnrarh 370 1 L. L. NNP cord-345222-otfnrarh 370 2 reuteri reuteri NNP cord-345222-otfnrarh 370 3 may may MD cord-345222-otfnrarh 370 4 reduce reduce VB cord-345222-otfnrarh 370 5 these these DT cord-345222-otfnrarh 370 6 outcomes outcome NNS cord-345222-otfnrarh 370 7 because because IN cord-345222-otfnrarh 370 8 of of IN cord-345222-otfnrarh 370 9 its -PRON- PRP$ cord-345222-otfnrarh 370 10 immunomodulation immunomodulation NN cord-345222-otfnrarh 370 11 and and CC cord-345222-otfnrarh 370 12 bactericidal bactericidal JJ cord-345222-otfnrarh 370 13 properties property NNS cord-345222-otfnrarh 370 14 . . . cord-345222-otfnrarh 371 1 A a DT cord-345222-otfnrarh 371 2 large large JJ cord-345222-otfnrarh 371 3 , , , cord-345222-otfnrarh 371 4 double double JJ cord-345222-otfnrarh 371 5 - - HYPH cord-345222-otfnrarh 371 6 blinded blinded JJ cord-345222-otfnrarh 371 7 , , , cord-345222-otfnrarh 371 8 randomized randomized JJ cord-345222-otfnrarh 371 9 controlled control VBN cord-345222-otfnrarh 371 10 trial trial NN cord-345222-otfnrarh 371 11 ( ( -LRB- cord-345222-otfnrarh 371 12 RCT RCT NNP cord-345222-otfnrarh 371 13 ) ) -RRB- cord-345222-otfnrarh 371 14 using use VBG cord-345222-otfnrarh 371 15 L. L. NNP cord-345222-otfnrarh 371 16 reuteri reuteri NNP cord-345222-otfnrarh 371 17 was be VBD cord-345222-otfnrarh 371 18 performed perform VBN cord-345222-otfnrarh 371 19 to to TO cord-345222-otfnrarh 371 20 test test VB cord-345222-otfnrarh 371 21 this this DT cord-345222-otfnrarh 371 22 hypothesis hypothesis NN cord-345222-otfnrarh 371 23 in in IN cord-345222-otfnrarh 371 24 preterm preterm JJ cord-345222-otfnrarh 371 25 infants infant NNS cord-345222-otfnrarh 371 26 . . . cord-345222-otfnrarh 372 1 This this DT cord-345222-otfnrarh 372 2 study study NN cord-345222-otfnrarh 372 3 suggested suggest VBD cord-345222-otfnrarh 372 4 that that IN cord-345222-otfnrarh 372 5 although although IN cord-345222-otfnrarh 372 6 L. L. NNP cord-345222-otfnrarh 372 7 reuteri reuteri NNP cord-345222-otfnrarh 372 8 did do VBD cord-345222-otfnrarh 372 9 not not RB cord-345222-otfnrarh 372 10 appear appear VB cord-345222-otfnrarh 372 11 to to TO cord-345222-otfnrarh 372 12 decrease decrease VB cord-345222-otfnrarh 372 13 the the DT cord-345222-otfnrarh 372 14 rate rate NN cord-345222-otfnrarh 372 15 of of IN cord-345222-otfnrarh 372 16 death death NN cord-345222-otfnrarh 372 17 or or CC cord-345222-otfnrarh 372 18 nosocomial nosocomial JJ cord-345222-otfnrarh 372 19 infection infection NN cord-345222-otfnrarh 372 20 , , , cord-345222-otfnrarh 372 21 the the DT cord-345222-otfnrarh 372 22 trends trend NNS cord-345222-otfnrarh 372 23 suggest suggest VBP cord-345222-otfnrarh 372 24 a a DT cord-345222-otfnrarh 372 25 protective protective JJ cord-345222-otfnrarh 372 26 role role NN cord-345222-otfnrarh 372 27 consistent consistent JJ cord-345222-otfnrarh 372 28 with with IN cord-345222-otfnrarh 372 29 what what WP cord-345222-otfnrarh 372 30 has have VBZ cord-345222-otfnrarh 372 31 been be VBN cord-345222-otfnrarh 372 32 observed observe VBN cord-345222-otfnrarh 372 33 in in IN cord-345222-otfnrarh 372 34 the the DT cord-345222-otfnrarh 372 35 literature literature NN cord-345222-otfnrarh 372 36 : : : cord-345222-otfnrarh 372 37 a a DT cord-345222-otfnrarh 372 38 protective protective JJ cord-345222-otfnrarh 372 39 role role NN cord-345222-otfnrarh 372 40 for for IN cord-345222-otfnrarh 372 41 mortality mortality NN cord-345222-otfnrarh 372 42 , , , cord-345222-otfnrarh 372 43 nosocomial nosocomial JJ cord-345222-otfnrarh 372 44 infection infection NN cord-345222-otfnrarh 372 45 , , , cord-345222-otfnrarh 372 46 and and CC cord-345222-otfnrarh 372 47 necrotizing necrotize VBG cord-345222-otfnrarh 372 48 enterocolitis enterocolitis NN cord-345222-otfnrarh 372 49 . . . cord-345222-otfnrarh 373 1 Feeding feed VBG cord-345222-otfnrarh 373 2 intolerance intolerance NN cord-345222-otfnrarh 373 3 and and CC cord-345222-otfnrarh 373 4 duration duration NN cord-345222-otfnrarh 373 5 of of IN cord-345222-otfnrarh 373 6 hospitalization hospitalization NN cord-345222-otfnrarh 373 7 were be VBD cord-345222-otfnrarh 373 8 significantly significantly RB cord-345222-otfnrarh 373 9 decreased decrease VBN cord-345222-otfnrarh 373 10 in in IN cord-345222-otfnrarh 373 11 premature premature JJ cord-345222-otfnrarh 373 12 infants infant NNS cord-345222-otfnrarh 373 13 less less JJR cord-345222-otfnrarh 373 14 than than IN cord-345222-otfnrarh 373 15 1500 1500 CD cord-345222-otfnrarh 373 16 g. g. NNP cord-345222-otfnrarh 373 17 117 117 CD cord-345222-otfnrarh 374 1 The the DT cord-345222-otfnrarh 374 2 use use NN cord-345222-otfnrarh 374 3 of of IN cord-345222-otfnrarh 374 4 formulas formula NNS cord-345222-otfnrarh 374 5 supplemented supplement VBN cord-345222-otfnrarh 374 6 with with IN cord-345222-otfnrarh 374 7 probiotics probiotic NNS cord-345222-otfnrarh 374 8 ( ( -LRB- cord-345222-otfnrarh 374 9 particularly particularly RB cord-345222-otfnrarh 374 10 Bifidobacterium bifidobacterium NN cord-345222-otfnrarh 374 11 lactis lactis NN cord-345222-otfnrarh 374 12 and and CC cord-345222-otfnrarh 374 13 Lactobacillus Lactobacillus NNP cord-345222-otfnrarh 374 14 GG GG NNP cord-345222-otfnrarh 374 15 ) ) -RRB- cord-345222-otfnrarh 374 16 seems seem VBZ cord-345222-otfnrarh 374 17 to to TO cord-345222-otfnrarh 374 18 decrease decrease VB cord-345222-otfnrarh 374 19 the the DT cord-345222-otfnrarh 374 20 incidence incidence NN cord-345222-otfnrarh 374 21 ( ( -LRB- cord-345222-otfnrarh 374 22 up up IN cord-345222-otfnrarh 374 23 to to TO cord-345222-otfnrarh 374 24 57 57 CD cord-345222-otfnrarh 374 25 % % NN cord-345222-otfnrarh 374 26 ) ) -RRB- cord-345222-otfnrarh 374 27 and and CC cord-345222-otfnrarh 374 28 severity severity NN cord-345222-otfnrarh 374 29 of of IN cord-345222-otfnrarh 374 30 infectious infectious JJ cord-345222-otfnrarh 374 31 acute acute JJ cord-345222-otfnrarh 374 32 diarrhea diarrhea NN cord-345222-otfnrarh 374 33 . . . cord-345222-otfnrarh 375 1 Symbiotics symbiotic NNS cord-345222-otfnrarh 375 2 , , , cord-345222-otfnrarh 375 3 a a DT cord-345222-otfnrarh 375 4 combination combination NN cord-345222-otfnrarh 375 5 of of IN cord-345222-otfnrarh 375 6 prebiotics prebiotic NNS cord-345222-otfnrarh 375 7 and and CC cord-345222-otfnrarh 375 8 probiotics probiotic NNS cord-345222-otfnrarh 375 9 that that WDT cord-345222-otfnrarh 375 10 beneficially beneficially RB cord-345222-otfnrarh 375 11 affect affect VBP cord-345222-otfnrarh 375 12 the the DT cord-345222-otfnrarh 375 13 host host NN cord-345222-otfnrarh 375 14 by by IN cord-345222-otfnrarh 375 15 improving improve VBG cord-345222-otfnrarh 375 16 survival survival NN cord-345222-otfnrarh 375 17 and and CC cord-345222-otfnrarh 375 18 implantation implantation NN cord-345222-otfnrarh 375 19 of of IN cord-345222-otfnrarh 375 20 live live JJ cord-345222-otfnrarh 375 21 microbial microbial JJ cord-345222-otfnrarh 375 22 dietary dietary JJ cord-345222-otfnrarh 375 23 supplements supplement NNS cord-345222-otfnrarh 375 24 in in IN cord-345222-otfnrarh 375 25 the the DT cord-345222-otfnrarh 375 26 gastrointestinal gastrointestinal JJ cord-345222-otfnrarh 375 27 tract tract NN cord-345222-otfnrarh 375 28 , , , cord-345222-otfnrarh 375 29 has have VBZ cord-345222-otfnrarh 375 30 recently recently RB cord-345222-otfnrarh 375 31 been be VBN cord-345222-otfnrarh 375 32 evaluated evaluate VBN cord-345222-otfnrarh 375 33 by by IN cord-345222-otfnrarh 375 34 two two CD cord-345222-otfnrarh 375 35 European european JJ cord-345222-otfnrarh 375 36 RCTs rct NNS cord-345222-otfnrarh 375 37 for for IN cord-345222-otfnrarh 375 38 the the DT cord-345222-otfnrarh 375 39 management management NN cord-345222-otfnrarh 375 40 of of IN cord-345222-otfnrarh 375 41 AGE AGE NNP cord-345222-otfnrarh 375 42 . . . cord-345222-otfnrarh 376 1 These these DT cord-345222-otfnrarh 376 2 studies study NNS cord-345222-otfnrarh 376 3 are be VBP cord-345222-otfnrarh 376 4 promising promising JJ cord-345222-otfnrarh 376 5 , , , cord-345222-otfnrarh 376 6 but but CC cord-345222-otfnrarh 376 7 presently presently RB cord-345222-otfnrarh 376 8 it -PRON- PRP cord-345222-otfnrarh 376 9 would would MD cord-345222-otfnrarh 376 10 not not RB cord-345222-otfnrarh 376 11 be be VB cord-345222-otfnrarh 376 12 appropriate appropriate JJ cord-345222-otfnrarh 376 13 to to TO cord-345222-otfnrarh 376 14 recommend recommend VB cord-345222-otfnrarh 376 15 the the DT cord-345222-otfnrarh 376 16 use use NN cord-345222-otfnrarh 376 17 of of IN cord-345222-otfnrarh 376 18 symbiotics symbiotic NNS cord-345222-otfnrarh 376 19 until until IN cord-345222-otfnrarh 376 20 confirmatory confirmatory JJ cord-345222-otfnrarh 376 21 data datum NNS cord-345222-otfnrarh 376 22 are be VBP cord-345222-otfnrarh 376 23 available available JJ cord-345222-otfnrarh 376 24 . . . cord-345222-otfnrarh 377 1 1 1 LS cord-345222-otfnrarh 378 1 Dehydration dehydration NN cord-345222-otfnrarh 378 2 is be VBZ cord-345222-otfnrarh 378 3 probably probably RB cord-345222-otfnrarh 378 4 the the DT cord-345222-otfnrarh 378 5 main main JJ cord-345222-otfnrarh 378 6 complication complication NN cord-345222-otfnrarh 378 7 of of IN cord-345222-otfnrarh 378 8 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 378 9 in in IN cord-345222-otfnrarh 378 10 childhood childhood NN cord-345222-otfnrarh 378 11 . . . cord-345222-otfnrarh 379 1 WHO who WP cord-345222-otfnrarh 379 2 classification classification NN cord-345222-otfnrarh 379 3 of of IN cord-345222-otfnrarh 379 4 patients patient NNS cord-345222-otfnrarh 379 5 ' ' POS cord-345222-otfnrarh 379 6 hydration hydration NN cord-345222-otfnrarh 379 7 status status NN cord-345222-otfnrarh 379 8 is be VBZ cord-345222-otfnrarh 379 9 based base VBN cord-345222-otfnrarh 379 10 on on IN cord-345222-otfnrarh 379 11 the the DT cord-345222-otfnrarh 379 12 presence presence NN cord-345222-otfnrarh 379 13 of of IN cord-345222-otfnrarh 379 14 symptoms symptom NNS cord-345222-otfnrarh 379 15 and and CC cord-345222-otfnrarh 379 16 signs sign NNS cord-345222-otfnrarh 379 17 . . . cord-345222-otfnrarh 380 1 The the DT cord-345222-otfnrarh 380 2 presence presence NN cord-345222-otfnrarh 380 3 of of IN cord-345222-otfnrarh 380 4 one one CD cord-345222-otfnrarh 380 5 of of IN cord-345222-otfnrarh 380 6 these these DT cord-345222-otfnrarh 380 7 signs sign NNS cord-345222-otfnrarh 380 8 or or CC cord-345222-otfnrarh 380 9 symptoms symptom NNS cord-345222-otfnrarh 380 10 immediately immediately RB cord-345222-otfnrarh 380 11 classifies classify VBZ cord-345222-otfnrarh 380 12 the the DT cord-345222-otfnrarh 380 13 patient patient NN cord-345222-otfnrarh 380 14 as as IN cord-345222-otfnrarh 380 15 a a DT cord-345222-otfnrarh 380 16 more more RBR cord-345222-otfnrarh 380 17 severe severe JJ cord-345222-otfnrarh 380 18 case case NN cord-345222-otfnrarh 380 19 . . . cord-345222-otfnrarh 381 1 Table table NN cord-345222-otfnrarh 381 2 4 4 CD cord-345222-otfnrarh 381 3 summarizes summarize VBZ cord-345222-otfnrarh 381 4 the the DT cord-345222-otfnrarh 381 5 WHO WHO NNP cord-345222-otfnrarh 381 6 management management NN cord-345222-otfnrarh 381 7 of of IN cord-345222-otfnrarh 381 8 rehydration rehydration NN cord-345222-otfnrarh 381 9 . . . cord-345222-otfnrarh 382 1 118 118 CD cord-345222-otfnrarh 382 2 , , , cord-345222-otfnrarh 382 3 119 119 CD cord-345222-otfnrarh 382 4 All all DT cord-345222-otfnrarh 382 5 moderate moderate JJ cord-345222-otfnrarh 382 6 and and CC cord-345222-otfnrarh 382 7 severe severe JJ cord-345222-otfnrarh 382 8 patients patient NNS cord-345222-otfnrarh 382 9 require require VBP cord-345222-otfnrarh 382 10 close close JJ cord-345222-otfnrarh 382 11 monitoring monitoring NN cord-345222-otfnrarh 382 12 , , , cord-345222-otfnrarh 382 13 but but CC cord-345222-otfnrarh 382 14 patients patient NNS cord-345222-otfnrarh 382 15 at at IN cord-345222-otfnrarh 382 16 the the DT cord-345222-otfnrarh 382 17 extreme extreme JJ cord-345222-otfnrarh 382 18 ages age NNS cord-345222-otfnrarh 382 19 of of IN cord-345222-otfnrarh 382 20 life life NN cord-345222-otfnrarh 382 21 , , , cord-345222-otfnrarh 382 22 especially especially RB cord-345222-otfnrarh 382 23 children child NNS cord-345222-otfnrarh 382 24 under under IN cord-345222-otfnrarh 382 25 18 18 CD cord-345222-otfnrarh 382 26 months month NNS cord-345222-otfnrarh 382 27 , , , cord-345222-otfnrarh 382 28 require require VBP cord-345222-otfnrarh 382 29 meticulous meticulous JJ cord-345222-otfnrarh 382 30 observation observation NN cord-345222-otfnrarh 382 31 and and CC cord-345222-otfnrarh 382 32 immediate immediate JJ cord-345222-otfnrarh 382 33 measures measure NNS cord-345222-otfnrarh 382 34 if if IN cord-345222-otfnrarh 382 35 their -PRON- PRP$ cord-345222-otfnrarh 382 36 condition condition NN cord-345222-otfnrarh 382 37 worsens worsen VBZ cord-345222-otfnrarh 382 38 . . . cord-345222-otfnrarh 383 1 According accord VBG cord-345222-otfnrarh 383 2 to to IN cord-345222-otfnrarh 383 3 current current JJ cord-345222-otfnrarh 383 4 WHO WHO NNP cord-345222-otfnrarh 383 5 recommendations recommendation NNS cord-345222-otfnrarh 383 6 , , , cord-345222-otfnrarh 383 7 oral oral JJ cord-345222-otfnrarh 383 8 rehydration rehydration NN cord-345222-otfnrarh 383 9 therapy therapy NN cord-345222-otfnrarh 383 10 ( ( -LRB- cord-345222-otfnrarh 383 11 ORT ORT NNP cord-345222-otfnrarh 383 12 ) ) -RRB- cord-345222-otfnrarh 383 13 is be VBZ cord-345222-otfnrarh 383 14 considered consider VBN cord-345222-otfnrarh 383 15 the the DT cord-345222-otfnrarh 383 16 treatment treatment NN cord-345222-otfnrarh 383 17 of of IN cord-345222-otfnrarh 383 18 choice choice NN cord-345222-otfnrarh 383 19 to to TO cord-345222-otfnrarh 383 20 replace replace VB cord-345222-otfnrarh 383 21 fluid fluid NN cord-345222-otfnrarh 383 22 and and CC cord-345222-otfnrarh 383 23 electrolyte electrolyte JJ cord-345222-otfnrarh 383 24 losses loss NNS cord-345222-otfnrarh 383 25 caused cause VBN cord-345222-otfnrarh 383 26 by by IN cord-345222-otfnrarh 383 27 diarrhea diarrhea NN cord-345222-otfnrarh 383 28 in in IN cord-345222-otfnrarh 383 29 children child NNS cord-345222-otfnrarh 383 30 with with IN cord-345222-otfnrarh 383 31 mild mild JJ cord-345222-otfnrarh 383 32 to to IN cord-345222-otfnrarh 383 33 moderate moderate JJ cord-345222-otfnrarh 383 34 dehydration dehydration NN cord-345222-otfnrarh 383 35 . . . cord-345222-otfnrarh 384 1 Intravenous intravenous JJ cord-345222-otfnrarh 384 2 rehydration rehydration NN cord-345222-otfnrarh 384 3 is be VBZ cord-345222-otfnrarh 384 4 the the DT cord-345222-otfnrarh 384 5 treatment treatment NN cord-345222-otfnrarh 384 6 of of IN cord-345222-otfnrarh 384 7 choice choice NN cord-345222-otfnrarh 384 8 in in IN cord-345222-otfnrarh 384 9 cases case NNS cord-345222-otfnrarh 384 10 of of IN cord-345222-otfnrarh 384 11 failure failure NN cord-345222-otfnrarh 384 12 of of IN cord-345222-otfnrarh 384 13 ORT ORT NNP cord-345222-otfnrarh 384 14 , , , cord-345222-otfnrarh 384 15 and and CC cord-345222-otfnrarh 384 16 it -PRON- PRP cord-345222-otfnrarh 384 17 has have VBZ cord-345222-otfnrarh 384 18 to to TO cord-345222-otfnrarh 384 19 be be VB cord-345222-otfnrarh 384 20 reserved reserve VBN cord-345222-otfnrarh 384 21 for for IN cord-345222-otfnrarh 384 22 patients patient NNS cord-345222-otfnrarh 384 23 with with IN cord-345222-otfnrarh 384 24 severe severe JJ cord-345222-otfnrarh 384 25 dehydration dehydration NN cord-345222-otfnrarh 384 26 or or CC cord-345222-otfnrarh 384 27 who who WP cord-345222-otfnrarh 384 28 eliminate eliminate VBP cord-345222-otfnrarh 384 29 more more JJR cord-345222-otfnrarh 384 30 than than IN cord-345222-otfnrarh 384 31 10 10 CD cord-345222-otfnrarh 384 32 - - SYM cord-345222-otfnrarh 384 33 20 20 CD cord-345222-otfnrarh 384 34 mL/ mL/ NNS cord-345222-otfnrarh 384 35 kg kg NN cord-345222-otfnrarh 384 36 / / SYM cord-345222-otfnrarh 384 37 hour hour NN cord-345222-otfnrarh 384 38 . . . cord-345222-otfnrarh 385 1 In in IN cord-345222-otfnrarh 385 2 the the DT cord-345222-otfnrarh 385 3 1960s 1960 NNS cord-345222-otfnrarh 385 4 , , , cord-345222-otfnrarh 385 5 efforts effort NNS cord-345222-otfnrarh 385 6 by by IN cord-345222-otfnrarh 385 7 young young JJ cord-345222-otfnrarh 385 8 scientists scientist NNS cord-345222-otfnrarh 385 9 and and CC cord-345222-otfnrarh 385 10 researchers researcher NNS cord-345222-otfnrarh 385 11 led lead VBD cord-345222-otfnrarh 385 12 to to IN cord-345222-otfnrarh 385 13 the the DT cord-345222-otfnrarh 385 14 development development NN cord-345222-otfnrarh 385 15 of of IN cord-345222-otfnrarh 385 16 ORT ORT NNP cord-345222-otfnrarh 385 17 for for IN cord-345222-otfnrarh 385 18 the the DT cord-345222-otfnrarh 385 19 treatment treatment NN cord-345222-otfnrarh 385 20 of of IN cord-345222-otfnrarh 385 21 dehydration dehydration NN cord-345222-otfnrarh 385 22 that that WDT cord-345222-otfnrarh 385 23 often often RB cord-345222-otfnrarh 385 24 accompanies accompany VBZ cord-345222-otfnrarh 385 25 acute acute JJ cord-345222-otfnrarh 385 26 attacks attack NNS cord-345222-otfnrarh 385 27 of of IN cord-345222-otfnrarh 385 28 diarrhea diarrhea NN cord-345222-otfnrarh 385 29 . . . cord-345222-otfnrarh 386 1 Many many JJ cord-345222-otfnrarh 386 2 members member NNS cord-345222-otfnrarh 386 3 of of IN cord-345222-otfnrarh 386 4 the the DT cord-345222-otfnrarh 386 5 research research NN cord-345222-otfnrarh 386 6 team team NN cord-345222-otfnrarh 386 7 responsible responsible JJ cord-345222-otfnrarh 386 8 for for IN cord-345222-otfnrarh 386 9 this this DT cord-345222-otfnrarh 386 10 discovery discovery NN cord-345222-otfnrarh 386 11 were be VBD cord-345222-otfnrarh 386 12 associated associate VBN cord-345222-otfnrarh 386 13 with with IN cord-345222-otfnrarh 386 14 noteworthy noteworthy JJ cord-345222-otfnrarh 386 15 universities university NNS cord-345222-otfnrarh 386 16 and and CC cord-345222-otfnrarh 386 17 medical medical JJ cord-345222-otfnrarh 386 18 research research NN cord-345222-otfnrarh 386 19 centers center NNS cord-345222-otfnrarh 386 20 in in IN cord-345222-otfnrarh 386 21 the the DT cord-345222-otfnrarh 386 22 US US NNP cord-345222-otfnrarh 386 23 . . . cord-345222-otfnrarh 387 1 The the DT cord-345222-otfnrarh 387 2 goal goal NN cord-345222-otfnrarh 387 3 of of IN cord-345222-otfnrarh 387 4 their -PRON- PRP$ cord-345222-otfnrarh 387 5 research research NN cord-345222-otfnrarh 387 6 was be VBD cord-345222-otfnrarh 387 7 to to TO cord-345222-otfnrarh 387 8 devise devise VB cord-345222-otfnrarh 387 9 effective effective JJ cord-345222-otfnrarh 387 10 therapies therapy NNS cord-345222-otfnrarh 387 11 for for IN cord-345222-otfnrarh 387 12 cholera cholera NN cord-345222-otfnrarh 387 13 - - HYPH cord-345222-otfnrarh 387 14 induced induce VBN cord-345222-otfnrarh 387 15 diarrhea diarrhea NN cord-345222-otfnrarh 387 16 ; ; : cord-345222-otfnrarh 387 17 as as IN cord-345222-otfnrarh 387 18 a a DT cord-345222-otfnrarh 387 19 result result NN cord-345222-otfnrarh 387 20 of of IN cord-345222-otfnrarh 387 21 their -PRON- PRP$ cord-345222-otfnrarh 387 22 hard hard JJ cord-345222-otfnrarh 387 23 work work NN cord-345222-otfnrarh 387 24 , , , cord-345222-otfnrarh 387 25 they -PRON- PRP cord-345222-otfnrarh 387 26 developed develop VBD cord-345222-otfnrarh 387 27 a a DT cord-345222-otfnrarh 387 28 new new JJ cord-345222-otfnrarh 387 29 framework framework NN cord-345222-otfnrarh 387 30 for for IN cord-345222-otfnrarh 387 31 treatment treatment NN cord-345222-otfnrarh 387 32 that that WDT cord-345222-otfnrarh 387 33 would would MD cord-345222-otfnrarh 387 34 soon soon RB cord-345222-otfnrarh 387 35 be be VB cord-345222-otfnrarh 387 36 adopted adopt VBN cord-345222-otfnrarh 387 37 throughout throughout IN cord-345222-otfnrarh 387 38 the the DT cord-345222-otfnrarh 387 39 developing develop VBG cord-345222-otfnrarh 387 40 world world NN cord-345222-otfnrarh 387 41 as as IN cord-345222-otfnrarh 387 42 a a DT cord-345222-otfnrarh 387 43 key key JJ cord-345222-otfnrarh 387 44 element element NN cord-345222-otfnrarh 387 45 in in IN cord-345222-otfnrarh 387 46 the the DT cord-345222-otfnrarh 387 47 overall overall JJ cord-345222-otfnrarh 387 48 strategy strategy NN cord-345222-otfnrarh 387 49 to to TO cord-345222-otfnrarh 387 50 combat combat VB cord-345222-otfnrarh 387 51 acute acute JJ cord-345222-otfnrarh 387 52 diarrhea diarrhea NN cord-345222-otfnrarh 387 53 and and CC cord-345222-otfnrarh 387 54 the the DT cord-345222-otfnrarh 387 55 potentially potentially RB cord-345222-otfnrarh 387 56 fatal fatal JJ cord-345222-otfnrarh 387 57 dehydration dehydration NN cord-345222-otfnrarh 387 58 that that WDT cord-345222-otfnrarh 387 59 accompanies accompany VBZ cord-345222-otfnrarh 387 60 the the DT cord-345222-otfnrarh 387 61 disease disease NN cord-345222-otfnrarh 387 62 . . . cord-345222-otfnrarh 388 1 In in IN cord-345222-otfnrarh 388 2 an an DT cord-345222-otfnrarh 388 3 article article NN cord-345222-otfnrarh 388 4 published publish VBN cord-345222-otfnrarh 388 5 in in IN cord-345222-otfnrarh 388 6 1968 1968 CD cord-345222-otfnrarh 388 7 in in IN cord-345222-otfnrarh 388 8 the the DT cord-345222-otfnrarh 388 9 Lancet Lancet NNP cord-345222-otfnrarh 388 10 , , , cord-345222-otfnrarh 388 11 it -PRON- PRP cord-345222-otfnrarh 388 12 was be VBD cord-345222-otfnrarh 388 13 confirmed confirm VBN cord-345222-otfnrarh 388 14 that that IN cord-345222-otfnrarh 388 15 cholera cholera NN cord-345222-otfnrarh 388 16 patients patient NNS cord-345222-otfnrarh 388 17 could could MD cord-345222-otfnrarh 388 18 be be VB cord-345222-otfnrarh 388 19 rehydrated rehydrate VBN cord-345222-otfnrarh 388 20 orally orally RB cord-345222-otfnrarh 388 21 with with IN cord-345222-otfnrarh 388 22 a a DT cord-345222-otfnrarh 388 23 simple simple JJ cord-345222-otfnrarh 388 24 solution solution NN cord-345222-otfnrarh 388 25 of of IN cord-345222-otfnrarh 388 26 water water NN cord-345222-otfnrarh 388 27 , , , cord-345222-otfnrarh 388 28 salt salt NN cord-345222-otfnrarh 388 29 , , , cord-345222-otfnrarh 388 30 and and CC cord-345222-otfnrarh 388 31 sugar sugar NN cord-345222-otfnrarh 388 32 , , , cord-345222-otfnrarh 388 33 and and CC cord-345222-otfnrarh 388 34 equally equally RB cord-345222-otfnrarh 388 35 importantly importantly RB cord-345222-otfnrarh 388 36 that that DT cord-345222-otfnrarh 388 37 field field NN cord-345222-otfnrarh 388 38 staff staff NN cord-345222-otfnrarh 388 39 could could MD cord-345222-otfnrarh 388 40 easily easily RB cord-345222-otfnrarh 388 41 be be VB cord-345222-otfnrarh 388 42 trained train VBN cord-345222-otfnrarh 388 43 to to TO cord-345222-otfnrarh 388 44 administer administer VB cord-345222-otfnrarh 388 45 the the DT cord-345222-otfnrarh 388 46 therapy therapy NN cord-345222-otfnrarh 388 47 . . . cord-345222-otfnrarh 389 1 As as IN cord-345222-otfnrarh 389 2 stated state VBN cord-345222-otfnrarh 389 3 in in IN cord-345222-otfnrarh 389 4 the the DT cord-345222-otfnrarh 389 5 article article NN cord-345222-otfnrarh 389 6 , , , cord-345222-otfnrarh 389 7 ORT ORT NNP cord-345222-otfnrarh 389 8 also also RB cord-345222-otfnrarh 389 9 offers offer VBZ cord-345222-otfnrarh 389 10 a a DT cord-345222-otfnrarh 389 11 practical practical JJ cord-345222-otfnrarh 389 12 treatment treatment NN cord-345222-otfnrarh 389 13 for for IN cord-345222-otfnrarh 389 14 large large JJ cord-345222-otfnrarh 389 15 numbers number NNS cord-345222-otfnrarh 389 16 of of IN cord-345222-otfnrarh 389 17 patients patient NNS cord-345222-otfnrarh 389 18 in in IN cord-345222-otfnrarh 389 19 the the DT cord-345222-otfnrarh 389 20 developing develop VBG cord-345222-otfnrarh 389 21 world world NN cord-345222-otfnrarh 389 22 who who WP cord-345222-otfnrarh 389 23 do do VBP cord-345222-otfnrarh 389 24 not not RB cord-345222-otfnrarh 389 25 have have VB cord-345222-otfnrarh 389 26 access access NN cord-345222-otfnrarh 389 27 to to IN cord-345222-otfnrarh 389 28 traditional traditional JJ cord-345222-otfnrarh 389 29 intravenous intravenous JJ cord-345222-otfnrarh 389 30 drip drip NN cord-345222-otfnrarh 389 31 therapy therapy NN cord-345222-otfnrarh 389 32 . . . cord-345222-otfnrarh 390 1 At at IN cord-345222-otfnrarh 390 2 first first RB cord-345222-otfnrarh 390 3 , , , cord-345222-otfnrarh 390 4 studies study NNS cord-345222-otfnrarh 390 5 on on IN cord-345222-otfnrarh 390 6 the the DT cord-345222-otfnrarh 390 7 efficacy efficacy NN cord-345222-otfnrarh 390 8 of of IN cord-345222-otfnrarh 390 9 ORT ORT NNP cord-345222-otfnrarh 390 10 , , , cord-345222-otfnrarh 390 11 when when WRB cord-345222-otfnrarh 390 12 compared compare VBN cord-345222-otfnrarh 390 13 with with IN cord-345222-otfnrarh 390 14 intravenous intravenous JJ cord-345222-otfnrarh 390 15 therapy therapy NN cord-345222-otfnrarh 390 16 ( ( -LRB- cord-345222-otfnrarh 390 17 IVT IVT NNP cord-345222-otfnrarh 390 18 ) ) -RRB- cord-345222-otfnrarh 390 19 , , , cord-345222-otfnrarh 390 20 were be VBD cord-345222-otfnrarh 390 21 conducted conduct VBN cord-345222-otfnrarh 390 22 only only RB cord-345222-otfnrarh 390 23 in in IN cord-345222-otfnrarh 390 24 patients patient NNS cord-345222-otfnrarh 390 25 with with IN cord-345222-otfnrarh 390 26 cholera cholera NN cord-345222-otfnrarh 390 27 . . . cord-345222-otfnrarh 391 1 [ [ -LRB- cord-345222-otfnrarh 391 2 120 120 CD cord-345222-otfnrarh 391 3 ] ] -RRB- cord-345222-otfnrarh 391 4 [ [ -LRB- cord-345222-otfnrarh 391 5 121 121 CD cord-345222-otfnrarh 391 6 ] ] -RRB- cord-345222-otfnrarh 391 7 [ [ -LRB- cord-345222-otfnrarh 391 8 122 122 CD cord-345222-otfnrarh 391 9 ] ] -RRB- cord-345222-otfnrarh 392 1 Following follow VBG cord-345222-otfnrarh 392 2 that that IN cord-345222-otfnrarh 392 3 , , , cord-345222-otfnrarh 392 4 other other JJ cord-345222-otfnrarh 392 5 studies study NNS cord-345222-otfnrarh 392 6 established establish VBD cord-345222-otfnrarh 392 7 the the DT cord-345222-otfnrarh 392 8 effectiveness effectiveness NN cord-345222-otfnrarh 392 9 of of IN cord-345222-otfnrarh 392 10 ORT ORT NNP cord-345222-otfnrarh 392 11 in in IN cord-345222-otfnrarh 392 12 children child NNS cord-345222-otfnrarh 392 13 with with IN cord-345222-otfnrarh 392 14 acute acute JJ cord-345222-otfnrarh 392 15 diarrhea diarrhea NN cord-345222-otfnrarh 392 16 from from IN cord-345222-otfnrarh 392 17 other other JJ cord-345222-otfnrarh 392 18 causes cause NNS cord-345222-otfnrarh 392 19 . . . cord-345222-otfnrarh 393 1 123 123 CD cord-345222-otfnrarh 394 1 Some some DT cord-345222-otfnrarh 394 2 trials trial NNS cord-345222-otfnrarh 394 3 also also RB cord-345222-otfnrarh 394 4 compared compare VBD cord-345222-otfnrarh 394 5 the the DT cord-345222-otfnrarh 394 6 effectiveness effectiveness NN cord-345222-otfnrarh 394 7 of of IN cord-345222-otfnrarh 394 8 oral oral JJ cord-345222-otfnrarh 394 9 rehydration rehydration NN cord-345222-otfnrarh 394 10 submit submit VBP cord-345222-otfnrarh 394 11 your -PRON- PRP$ cord-345222-otfnrarh 394 12 manuscript manuscript NN cord-345222-otfnrarh 394 13 | | NNP cord-345222-otfnrarh 394 14 www.dovepress.com www.dovepress.com ADD cord-345222-otfnrarh 394 15 with with IN cord-345222-otfnrarh 394 16 IVT IVT NNP cord-345222-otfnrarh 394 17 in in IN cord-345222-otfnrarh 394 18 children child NNS cord-345222-otfnrarh 394 19 with with IN cord-345222-otfnrarh 394 20 different different JJ cord-345222-otfnrarh 394 21 degrees degree NNS cord-345222-otfnrarh 394 22 and and CC cord-345222-otfnrarh 394 23 types type NNS cord-345222-otfnrarh 394 24 of of IN cord-345222-otfnrarh 394 25 dehydration dehydration NN cord-345222-otfnrarh 394 26 ( ( -LRB- cord-345222-otfnrarh 394 27 mild mild JJ cord-345222-otfnrarh 394 28 , , , cord-345222-otfnrarh 394 29 moderate moderate JJ cord-345222-otfnrarh 394 30 , , , cord-345222-otfnrarh 394 31 severe severe JJ cord-345222-otfnrarh 394 32 , , , cord-345222-otfnrarh 394 33 and and CC cord-345222-otfnrarh 394 34 hypernatremic hypernatremic JJ cord-345222-otfnrarh 394 35 dehydration dehydration NN cord-345222-otfnrarh 394 36 ) ) -RRB- cord-345222-otfnrarh 394 37 , , , cord-345222-otfnrarh 394 38 and and CC cord-345222-otfnrarh 394 39 they -PRON- PRP cord-345222-otfnrarh 394 40 concluded conclude VBD cord-345222-otfnrarh 394 41 that that IN cord-345222-otfnrarh 394 42 the the DT cord-345222-otfnrarh 394 43 use use NN cord-345222-otfnrarh 394 44 of of IN cord-345222-otfnrarh 394 45 ORS ORS NNP cord-345222-otfnrarh 394 46 to to TO cord-345222-otfnrarh 394 47 rehydrate rehydrate VB cord-345222-otfnrarh 394 48 children child NNS cord-345222-otfnrarh 394 49 is be VBZ cord-345222-otfnrarh 394 50 safe safe JJ cord-345222-otfnrarh 394 51 and and CC cord-345222-otfnrarh 394 52 that that IN cord-345222-otfnrarh 394 53 there there EX cord-345222-otfnrarh 394 54 are be VBP cord-345222-otfnrarh 394 55 no no DT cord-345222-otfnrarh 394 56 significant significant JJ cord-345222-otfnrarh 394 57 differences difference NNS cord-345222-otfnrarh 394 58 in in IN cord-345222-otfnrarh 394 59 incidences incidence NNS cord-345222-otfnrarh 394 60 of of IN cord-345222-otfnrarh 394 61 hyponatremia hyponatremia NN cord-345222-otfnrarh 394 62 , , , cord-345222-otfnrarh 394 63 hypernatremia hypernatremia NN cord-345222-otfnrarh 394 64 , , , cord-345222-otfnrarh 394 65 mean mean JJ cord-345222-otfnrarh 394 66 duration duration NN cord-345222-otfnrarh 394 67 of of IN cord-345222-otfnrarh 394 68 diarrhea diarrhea NN cord-345222-otfnrarh 394 69 , , , cord-345222-otfnrarh 394 70 weight weight NN cord-345222-otfnrarh 394 71 gain gain NN cord-345222-otfnrarh 394 72 , , , cord-345222-otfnrarh 394 73 or or CC cord-345222-otfnrarh 394 74 total total JJ cord-345222-otfnrarh 394 75 fluid fluid NN cord-345222-otfnrarh 394 76 intake intake NN cord-345222-otfnrarh 394 77 if if IN cord-345222-otfnrarh 394 78 compared compare VBN cord-345222-otfnrarh 394 79 with with IN cord-345222-otfnrarh 394 80 IVT IVT NNP cord-345222-otfnrarh 394 81 . . . cord-345222-otfnrarh 395 1 In in IN cord-345222-otfnrarh 395 2 terms term NNS cord-345222-otfnrarh 395 3 of of IN cord-345222-otfnrarh 395 4 outcomes outcome NNS cord-345222-otfnrarh 395 5 , , , cord-345222-otfnrarh 395 6 ORT ORT NNP cord-345222-otfnrarh 395 7 was be VBD cord-345222-otfnrarh 395 8 associated associate VBN cord-345222-otfnrarh 395 9 with with IN cord-345222-otfnrarh 395 10 a a DT cord-345222-otfnrarh 395 11 higher high JJR cord-345222-otfnrarh 395 12 risk risk NN cord-345222-otfnrarh 395 13 of of IN cord-345222-otfnrarh 395 14 rehydration rehydration NN cord-345222-otfnrarh 395 15 failure failure NN cord-345222-otfnrarh 395 16 , , , cord-345222-otfnrarh 395 17 while while IN cord-345222-otfnrarh 395 18 babies baby NNS cord-345222-otfnrarh 395 19 treated treat VBN cord-345222-otfnrarh 395 20 with with IN cord-345222-otfnrarh 395 21 IVT IVT NNP cord-345222-otfnrarh 395 22 had have VBD cord-345222-otfnrarh 395 23 a a DT cord-345222-otfnrarh 395 24 significantly significantly RB cord-345222-otfnrarh 395 25 longer long RBR cord-345222-otfnrarh 395 26 stay stay VB cord-345222-otfnrarh 395 27 in in IN cord-345222-otfnrarh 395 28 hospital hospital NN cord-345222-otfnrarh 395 29 and and CC cord-345222-otfnrarh 395 30 a a DT cord-345222-otfnrarh 395 31 higher high JJR cord-345222-otfnrarh 395 32 risk risk NN cord-345222-otfnrarh 395 33 of of IN cord-345222-otfnrarh 395 34 phlebitis phlebitis NN cord-345222-otfnrarh 395 35 , , , cord-345222-otfnrarh 395 36 but but CC cord-345222-otfnrarh 395 37 no no DT cord-345222-otfnrarh 395 38 statistically statistically RB cord-345222-otfnrarh 395 39 significant significant JJ cord-345222-otfnrarh 395 40 differences difference NNS cord-345222-otfnrarh 395 41 were be VBD cord-345222-otfnrarh 395 42 seen see VBN cord-345222-otfnrarh 395 43 . . . cord-345222-otfnrarh 396 1 124 124 CD cord-345222-otfnrarh 397 1 The the DT cord-345222-otfnrarh 397 2 main main JJ cord-345222-otfnrarh 397 3 reason reason NN cord-345222-otfnrarh 397 4 for for IN cord-345222-otfnrarh 397 5 this this DT cord-345222-otfnrarh 397 6 failure failure NN cord-345222-otfnrarh 397 7 is be VBZ cord-345222-otfnrarh 397 8 that that IN cord-345222-otfnrarh 397 9 ORS ORS NNP cord-345222-otfnrarh 397 10 neither neither DT cord-345222-otfnrarh 397 11 reduces reduce VBZ cord-345222-otfnrarh 397 12 the the DT cord-345222-otfnrarh 397 13 frequency frequency NN cord-345222-otfnrarh 397 14 of of IN cord-345222-otfnrarh 397 15 bowel bowel NN cord-345222-otfnrarh 397 16 movements movement NNS cord-345222-otfnrarh 397 17 and and CC cord-345222-otfnrarh 397 18 fluid fluid JJ cord-345222-otfnrarh 397 19 loss loss NN cord-345222-otfnrarh 397 20 nor nor CC cord-345222-otfnrarh 397 21 shortens shorten VBZ cord-345222-otfnrarh 397 22 the the DT cord-345222-otfnrarh 397 23 duration duration NN cord-345222-otfnrarh 397 24 of of IN cord-345222-otfnrarh 397 25 illness illness NN cord-345222-otfnrarh 397 26 ; ; : cord-345222-otfnrarh 397 27 moreover moreover RB cord-345222-otfnrarh 397 28 , , , cord-345222-otfnrarh 397 29 the the DT cord-345222-otfnrarh 397 30 unpalatability unpalatability NN cord-345222-otfnrarh 397 31 of of IN cord-345222-otfnrarh 397 32 regular regular JJ cord-345222-otfnrarh 397 33 ORS ORS NNP cord-345222-otfnrarh 397 34 ( ( -LRB- cord-345222-otfnrarh 397 35 strong strong JJ cord-345222-otfnrarh 397 36 salty salty JJ cord-345222-otfnrarh 397 37 taste taste NN cord-345222-otfnrarh 397 38 ) ) -RRB- cord-345222-otfnrarh 397 39 also also RB cord-345222-otfnrarh 397 40 decreases decrease VBZ cord-345222-otfnrarh 397 41 this this DT cord-345222-otfnrarh 397 42 acceptance acceptance NN cord-345222-otfnrarh 397 43 . . . cord-345222-otfnrarh 398 1 However however RB cord-345222-otfnrarh 398 2 , , , cord-345222-otfnrarh 398 3 the the DT cord-345222-otfnrarh 398 4 most most RBS cord-345222-otfnrarh 398 5 important important JJ cord-345222-otfnrarh 398 6 aspect aspect NN cord-345222-otfnrarh 398 7 of of IN cord-345222-otfnrarh 398 8 treatment treatment NN cord-345222-otfnrarh 398 9 of of IN cord-345222-otfnrarh 398 10 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 398 11 is be VBZ cord-345222-otfnrarh 398 12 the the DT cord-345222-otfnrarh 398 13 water water NN cord-345222-otfnrarh 398 14 and and CC cord-345222-otfnrarh 398 15 electrolyte electrolyte JJ cord-345222-otfnrarh 398 16 balance balance NN cord-345222-otfnrarh 398 17 . . . cord-345222-otfnrarh 399 1 It -PRON- PRP cord-345222-otfnrarh 399 2 must must MD cord-345222-otfnrarh 399 3 be be VB cord-345222-otfnrarh 399 4 adjusted adjust VBN cord-345222-otfnrarh 399 5 according accord VBG cord-345222-otfnrarh 399 6 to to IN cord-345222-otfnrarh 399 7 serum serum NN cord-345222-otfnrarh 399 8 electrolytes electrolyte NNS cord-345222-otfnrarh 399 9 , , , cord-345222-otfnrarh 399 10 body body NN cord-345222-otfnrarh 399 11 water water NN cord-345222-otfnrarh 399 12 content content NN cord-345222-otfnrarh 399 13 ( ( -LRB- cord-345222-otfnrarh 399 14 greater great JJR cord-345222-otfnrarh 399 15 the the DT cord-345222-otfnrarh 399 16 younger young JJR cord-345222-otfnrarh 399 17 the the DT cord-345222-otfnrarh 399 18 child child NN cord-345222-otfnrarh 399 19 ) ) -RRB- cord-345222-otfnrarh 399 20 , , , cord-345222-otfnrarh 399 21 and and CC cord-345222-otfnrarh 399 22 the the DT cord-345222-otfnrarh 399 23 water water NN cord-345222-otfnrarh 399 24 demand demand NN cord-345222-otfnrarh 399 25 must must MD cord-345222-otfnrarh 399 26 be be VB cord-345222-otfnrarh 399 27 calculated calculate VBN cord-345222-otfnrarh 399 28 on on IN cord-345222-otfnrarh 399 29 the the DT cord-345222-otfnrarh 399 30 weight weight NN cord-345222-otfnrarh 399 31 of of IN cord-345222-otfnrarh 399 32 the the DT cord-345222-otfnrarh 399 33 newborn newborn JJ cord-345222-otfnrarh 399 34 infant infant NN cord-345222-otfnrarh 399 35 ( ( -LRB- cord-345222-otfnrarh 399 36 Table table NN cord-345222-otfnrarh 399 37 5A 5a NN cord-345222-otfnrarh 399 38 and and CC cord-345222-otfnrarh 399 39 B b NN cord-345222-otfnrarh 399 40 ) ) -RRB- cord-345222-otfnrarh 399 41 . . . cord-345222-otfnrarh 400 1 Different different JJ cord-345222-otfnrarh 400 2 ORS ORS NNP cord-345222-otfnrarh 400 3 are be VBP cord-345222-otfnrarh 400 4 now now RB cord-345222-otfnrarh 400 5 commercially commercially RB cord-345222-otfnrarh 400 6 available available JJ cord-345222-otfnrarh 400 7 ( ( -LRB- cord-345222-otfnrarh 400 8 Table table NN cord-345222-otfnrarh 400 9 6 6 CD cord-345222-otfnrarh 400 10 ) ) -RRB- cord-345222-otfnrarh 400 11 . . . cord-345222-otfnrarh 401 1 125 125 CD cord-345222-otfnrarh 402 1 Recently recently RB cord-345222-otfnrarh 402 2 , , , cord-345222-otfnrarh 402 3 some some DT cord-345222-otfnrarh 402 4 companies company NNS cord-345222-otfnrarh 402 5 have have VBP cord-345222-otfnrarh 402 6 added add VBN cord-345222-otfnrarh 402 7 probiotics probiotic NNS cord-345222-otfnrarh 402 8 to to IN cord-345222-otfnrarh 402 9 the the DT cord-345222-otfnrarh 402 10 saline saline NN cord-345222-otfnrarh 402 11 solution solution NN cord-345222-otfnrarh 402 12 to to TO cord-345222-otfnrarh 402 13 obtain obtain VB cord-345222-otfnrarh 402 14 a a DT cord-345222-otfnrarh 402 15 quick quick JJ cord-345222-otfnrarh 402 16 balance balance NN cord-345222-otfnrarh 402 17 of of IN cord-345222-otfnrarh 402 18 intestinal intestinal JJ cord-345222-otfnrarh 402 19 bacterial bacterial JJ cord-345222-otfnrarh 402 20 flora flora NNS cord-345222-otfnrarh 402 21 . . . cord-345222-otfnrarh 403 1 The the DT cord-345222-otfnrarh 403 2 infant infant NN cord-345222-otfnrarh 403 3 should should MD cord-345222-otfnrarh 403 4 be be VB cord-345222-otfnrarh 403 5 monitored monitor VBN cord-345222-otfnrarh 403 6 closely closely RB cord-345222-otfnrarh 403 7 to to TO cord-345222-otfnrarh 403 8 check check VB cord-345222-otfnrarh 403 9 the the DT cord-345222-otfnrarh 403 10 status status NN cord-345222-otfnrarh 403 11 of of IN cord-345222-otfnrarh 403 12 nutrition nutrition NN cord-345222-otfnrarh 403 13 and and CC cord-345222-otfnrarh 403 14 hydration hydration NN cord-345222-otfnrarh 403 15 . . . cord-345222-otfnrarh 404 1 Infants infant NNS cord-345222-otfnrarh 404 2 with with IN cord-345222-otfnrarh 404 3 moderate moderate JJ cord-345222-otfnrarh 404 4 dehydration dehydration NN cord-345222-otfnrarh 404 5 , , , cord-345222-otfnrarh 404 6 suspected suspect VBN cord-345222-otfnrarh 404 7 infected infect VBN cord-345222-otfnrarh 404 8 by by IN cord-345222-otfnrarh 404 9 EHEC EHEC NNP cord-345222-otfnrarh 404 10 , , , cord-345222-otfnrarh 404 11 with with IN cord-345222-otfnrarh 404 12 bloody bloody JJ cord-345222-otfnrarh 404 13 diarrhea diarrhea NN cord-345222-otfnrarh 404 14 , , , cord-345222-otfnrarh 404 15 or or CC cord-345222-otfnrarh 404 16 systemic systemic JJ cord-345222-otfnrarh 404 17 symptoms symptom NNS cord-345222-otfnrarh 404 18 should should MD cord-345222-otfnrarh 404 19 be be VB cord-345222-otfnrarh 404 20 hospitalized hospitalize VBN cord-345222-otfnrarh 404 21 . . . cord-345222-otfnrarh 405 1 These these DT cord-345222-otfnrarh 405 2 newborns newborn NNS cord-345222-otfnrarh 405 3 are be VBP cord-345222-otfnrarh 405 4 at at IN cord-345222-otfnrarh 405 5 high high JJ cord-345222-otfnrarh 405 6 risk risk NN cord-345222-otfnrarh 405 7 of of IN cord-345222-otfnrarh 405 8 secondary secondary JJ cord-345222-otfnrarh 405 9 complications complication NNS cord-345222-otfnrarh 405 10 . . . cord-345222-otfnrarh 406 1 During during IN cord-345222-otfnrarh 406 2 ORT ORT NNP cord-345222-otfnrarh 406 3 , , , cord-345222-otfnrarh 406 4 milk milk NN cord-345222-otfnrarh 406 5 - - HYPH cord-345222-otfnrarh 406 6 feeding feeding NN cord-345222-otfnrarh 406 7 is be VBZ cord-345222-otfnrarh 406 8 often often RB cord-345222-otfnrarh 406 9 temporarily temporarily RB cord-345222-otfnrarh 406 10 suspended suspend VBN cord-345222-otfnrarh 406 11 . . . cord-345222-otfnrarh 407 1 Among among IN cord-345222-otfnrarh 407 2 all all PDT cord-345222-otfnrarh 407 3 the the DT cord-345222-otfnrarh 407 4 oral oral JJ cord-345222-otfnrarh 407 5 solutions solution NNS cord-345222-otfnrarh 407 6 , , , cord-345222-otfnrarh 407 7 the the DT cord-345222-otfnrarh 407 8 ideal ideal JJ cord-345222-otfnrarh 407 9 one one NN cord-345222-otfnrarh 407 10 has have VBZ cord-345222-otfnrarh 407 11 a a DT cord-345222-otfnrarh 407 12 low low JJ cord-345222-otfnrarh 407 13 osmolarity osmolarity NN cord-345222-otfnrarh 407 14 ( ( -LRB- cord-345222-otfnrarh 407 15 210 210 CD cord-345222-otfnrarh 407 16 - - SYM cord-345222-otfnrarh 407 17 250 250 CD cord-345222-otfnrarh 407 18 mOsm mOsm NNP cord-345222-otfnrarh 407 19 / / SYM cord-345222-otfnrarh 407 20 L L NNP cord-345222-otfnrarh 407 21 ) ) -RRB- cord-345222-otfnrarh 407 22 and and CC cord-345222-otfnrarh 407 23 a a DT cord-345222-otfnrarh 407 24 sodium sodium NN cord-345222-otfnrarh 407 25 content content NN cord-345222-otfnrarh 407 26 of of IN cord-345222-otfnrarh 407 27 50 50 CD cord-345222-otfnrarh 407 28 - - SYM cord-345222-otfnrarh 407 29 60 60 CD cord-345222-otfnrarh 407 30 mmol mmol JJ cord-345222-otfnrarh 407 31 / / SYM cord-345222-otfnrarh 407 32 L l NN cord-345222-otfnrarh 407 33 to to TO cord-345222-otfnrarh 407 34 avoid avoid VB cord-345222-otfnrarh 407 35 high high JJ cord-345222-otfnrarh 407 36 levels level NNS cord-345222-otfnrarh 407 37 of of IN cord-345222-otfnrarh 407 38 serum serum NN cord-345222-otfnrarh 407 39 sodium sodium NN cord-345222-otfnrarh 407 40 . . . cord-345222-otfnrarh 408 1 The the DT cord-345222-otfnrarh 408 2 solution solution NN cord-345222-otfnrarh 408 3 should should MD cord-345222-otfnrarh 408 4 be be VB cord-345222-otfnrarh 408 5 administered administer VBN cord-345222-otfnrarh 408 6 frequently frequently RB cord-345222-otfnrarh 408 7 and and CC cord-345222-otfnrarh 408 8 in in IN cord-345222-otfnrarh 408 9 small small JJ cord-345222-otfnrarh 408 10 amounts amount NNS cord-345222-otfnrarh 408 11 to to TO cord-345222-otfnrarh 408 12 prevent prevent VB cord-345222-otfnrarh 408 13 vomiting vomiting NN cord-345222-otfnrarh 408 14 . . . cord-345222-otfnrarh 409 1 Initial initial JJ cord-345222-otfnrarh 409 2 oral oral JJ cord-345222-otfnrarh 409 3 rehydration rehydration NN cord-345222-otfnrarh 409 4 is be VBZ cord-345222-otfnrarh 409 5 50 50 CD cord-345222-otfnrarh 409 6 - - SYM cord-345222-otfnrarh 409 7 100 100 CD cord-345222-otfnrarh 409 8 mL ml NN cord-345222-otfnrarh 409 9 / / SYM cord-345222-otfnrarh 409 10 kg kg NNS cord-345222-otfnrarh 409 11 in in IN cord-345222-otfnrarh 409 12 the the DT cord-345222-otfnrarh 409 13 first first JJ cord-345222-otfnrarh 409 14 4 4 CD cord-345222-otfnrarh 409 15 hours hour NNS cord-345222-otfnrarh 409 16 . . . cord-345222-otfnrarh 410 1 126 126 CD cord-345222-otfnrarh 410 2 Also also RB cord-345222-otfnrarh 410 3 consider consider VB cord-345222-otfnrarh 410 4 giving give VBG cord-345222-otfnrarh 410 5 the the DT cord-345222-otfnrarh 410 6 ORS ORS NNP cord-345222-otfnrarh 410 7 via via IN cord-345222-otfnrarh 410 8 a a DT cord-345222-otfnrarh 410 9 nasogastric nasogastric NN cord-345222-otfnrarh 410 10 tube tube NN cord-345222-otfnrarh 410 11 if if IN cord-345222-otfnrarh 410 12 patients patient NNS cord-345222-otfnrarh 410 13 are be VBP cord-345222-otfnrarh 410 14 unable unable JJ cord-345222-otfnrarh 410 15 to to TO cord-345222-otfnrarh 410 16 drink drink VB cord-345222-otfnrarh 410 17 it -PRON- PRP cord-345222-otfnrarh 410 18 or or CC cord-345222-otfnrarh 410 19 if if IN cord-345222-otfnrarh 410 20 they -PRON- PRP cord-345222-otfnrarh 410 21 vomit vomit VBP cord-345222-otfnrarh 410 22 persistently persistently RB cord-345222-otfnrarh 410 23 and and CC cord-345222-otfnrarh 410 24 to to TO cord-345222-otfnrarh 410 25 monitor monitor VB cord-345222-otfnrarh 410 26 them -PRON- PRP cord-345222-otfnrarh 410 27 by by IN cord-345222-otfnrarh 410 28 regular regular JJ cord-345222-otfnrarh 410 29 clinical clinical JJ cord-345222-otfnrarh 410 30 assessment assessment NN cord-345222-otfnrarh 410 31 . . . cord-345222-otfnrarh 411 1 In in IN cord-345222-otfnrarh 411 2 cases case NNS cord-345222-otfnrarh 411 3 of of IN cord-345222-otfnrarh 411 4 failure failure NN cord-345222-otfnrarh 411 5 of of IN cord-345222-otfnrarh 411 6 oral oral JJ cord-345222-otfnrarh 411 7 rehydration rehydration NN cord-345222-otfnrarh 411 8 , , , cord-345222-otfnrarh 411 9 it -PRON- PRP cord-345222-otfnrarh 411 10 is be VBZ cord-345222-otfnrarh 411 11 necessary necessary JJ cord-345222-otfnrarh 411 12 to to TO cord-345222-otfnrarh 411 13 establish establish VB cord-345222-otfnrarh 411 14 an an DT cord-345222-otfnrarh 411 15 appropriate appropriate JJ cord-345222-otfnrarh 411 16 parenteral parenteral JJ cord-345222-otfnrarh 411 17 rehydration rehydration NN cord-345222-otfnrarh 411 18 fluid fluid NN cord-345222-otfnrarh 411 19 and and CC cord-345222-otfnrarh 411 20 electrolyte electrolyte JJ cord-345222-otfnrarh 411 21 solutions solution NNS cord-345222-otfnrarh 411 22 ( ( -LRB- cord-345222-otfnrarh 411 23 Table Table NNP cord-345222-otfnrarh 411 24 7 7 CD cord-345222-otfnrarh 411 25 ) ) -RRB- cord-345222-otfnrarh 411 26 . . . cord-345222-otfnrarh 412 1 127 127 CD cord-345222-otfnrarh 412 2 _SP cord-345222-otfnrarh 413 1 Pediatric pediatric JJ cord-345222-otfnrarh 413 2 presentations presentation NNS cord-345222-otfnrarh 413 3 of of IN cord-345222-otfnrarh 413 4 racecadotril racecadotril NNP cord-345222-otfnrarh 413 5 were be VBD cord-345222-otfnrarh 413 6 first first RB cord-345222-otfnrarh 413 7 authorized authorize VBN cord-345222-otfnrarh 413 8 in in IN cord-345222-otfnrarh 413 9 France France NNP cord-345222-otfnrarh 413 10 in in IN cord-345222-otfnrarh 413 11 1999 1999 CD cord-345222-otfnrarh 413 12 , , , cord-345222-otfnrarh 413 13 and and CC cord-345222-otfnrarh 413 14 today today NN cord-345222-otfnrarh 413 15 it -PRON- PRP cord-345222-otfnrarh 413 16 is be VBZ cord-345222-otfnrarh 413 17 approved approve VBN cord-345222-otfnrarh 413 18 and and CC cord-345222-otfnrarh 413 19 widely widely RB cord-345222-otfnrarh 413 20 used use VBN cord-345222-otfnrarh 413 21 in in IN cord-345222-otfnrarh 413 22 seven seven CD cord-345222-otfnrarh 413 23 European european JJ cord-345222-otfnrarh 413 24 countries country NNS cord-345222-otfnrarh 413 25 ( ( -LRB- cord-345222-otfnrarh 413 26 France France NNP cord-345222-otfnrarh 413 27 , , , cord-345222-otfnrarh 413 28 Spain Spain NNP cord-345222-otfnrarh 413 29 , , , cord-345222-otfnrarh 413 30 Italy Italy NNP cord-345222-otfnrarh 413 31 , , , cord-345222-otfnrarh 413 32 Portugal Portugal NNP cord-345222-otfnrarh 413 33 , , , cord-345222-otfnrarh 413 34 Greece Greece NNP cord-345222-otfnrarh 413 35 , , , cord-345222-otfnrarh 413 36 Bulgaria Bulgaria NNP cord-345222-otfnrarh 413 37 , , , cord-345222-otfnrarh 413 38 and and CC cord-345222-otfnrarh 413 39 Romania Romania NNP cord-345222-otfnrarh 413 40 ) ) -RRB- cord-345222-otfnrarh 413 41 and and CC cord-345222-otfnrarh 413 42 outside outside IN cord-345222-otfnrarh 413 43 Europe Europe NNP cord-345222-otfnrarh 413 44 . . . cord-345222-otfnrarh 414 1 128 128 CD cord-345222-otfnrarh 415 1 This this DT cord-345222-otfnrarh 415 2 antisecretory antisecretory NN cord-345222-otfnrarh 415 3 drug drug NN cord-345222-otfnrarh 415 4 is be VBZ cord-345222-otfnrarh 415 5 a a DT cord-345222-otfnrarh 415 6 peripherally peripherally RB cord-345222-otfnrarh 415 7 acting act VBG cord-345222-otfnrarh 415 8 enkephalinase enkephalinase NN cord-345222-otfnrarh 415 9 inhibitor inhibitor NN cord-345222-otfnrarh 415 10 that that WDT cord-345222-otfnrarh 415 11 reduces reduce VBZ cord-345222-otfnrarh 415 12 intestinal intestinal JJ cord-345222-otfnrarh 415 13 water water NN cord-345222-otfnrarh 415 14 and and CC cord-345222-otfnrarh 415 15 electrolyte electrolyte NN cord-345222-otfnrarh 415 16 hypersecretion hypersecretion NN cord-345222-otfnrarh 415 17 acting act VBG cord-345222-otfnrarh 415 18 on on IN cord-345222-otfnrarh 415 19 the the DT cord-345222-otfnrarh 415 20 enkephalins enkephalin NNS cord-345222-otfnrarh 415 21 ( ( -LRB- cord-345222-otfnrarh 415 22 neurotransmitters neurotransmitter NNS cord-345222-otfnrarh 415 23 of of IN cord-345222-otfnrarh 415 24 the the DT cord-345222-otfnrarh 415 25 gastrointestinal gastrointestinal JJ cord-345222-otfnrarh 415 26 tract tract NN cord-345222-otfnrarh 415 27 ) ) -RRB- cord-345222-otfnrarh 415 28 through through IN cord-345222-otfnrarh 415 29 the the DT cord-345222-otfnrarh 415 30 selective selective JJ cord-345222-otfnrarh 415 31 stimulation stimulation NN cord-345222-otfnrarh 415 32 of of IN cord-345222-otfnrarh 415 33 delta delta NN cord-345222-otfnrarh 415 34 receptors receptor NNS cord-345222-otfnrarh 415 35 inhibit inhibit VBP cord-345222-otfnrarh 415 36 adenylate adenylate NN cord-345222-otfnrarh 415 37 cyclase cyclase NN cord-345222-otfnrarh 415 38 activity activity NN cord-345222-otfnrarh 415 39 by by IN cord-345222-otfnrarh 415 40 reducing reduce VBG cord-345222-otfnrarh 415 41 the the DT cord-345222-otfnrarh 415 42 intracellular intracellular JJ cord-345222-otfnrarh 415 43 concentration concentration NN cord-345222-otfnrarh 415 44 of of IN cord-345222-otfnrarh 415 45 cAMP camp NN cord-345222-otfnrarh 415 46 , , , cord-345222-otfnrarh 415 47 thus thus RB cord-345222-otfnrarh 415 48 reducing reduce VBG cord-345222-otfnrarh 415 49 the the DT cord-345222-otfnrarh 415 50 secretion secretion NN cord-345222-otfnrarh 415 51 of of IN cord-345222-otfnrarh 415 52 water water NN cord-345222-otfnrarh 415 53 and and CC cord-345222-otfnrarh 415 54 electrolyte electrolyte NN cord-345222-otfnrarh 415 55 in in IN cord-345222-otfnrarh 415 56 the the DT cord-345222-otfnrarh 415 57 intestinal intestinal JJ cord-345222-otfnrarh 415 58 lumen lumen NN cord-345222-otfnrarh 415 59 . . . cord-345222-otfnrarh 416 1 The the DT cord-345222-otfnrarh 416 2 result result NN cord-345222-otfnrarh 416 3 is be VBZ cord-345222-otfnrarh 416 4 a a DT cord-345222-otfnrarh 416 5 reduction reduction NN cord-345222-otfnrarh 416 6 of of IN cord-345222-otfnrarh 416 7 water water NN cord-345222-otfnrarh 416 8 and and CC cord-345222-otfnrarh 416 9 electrolyte electrolyte JJ cord-345222-otfnrarh 416 10 secretion secretion NN cord-345222-otfnrarh 416 11 without without IN cord-345222-otfnrarh 416 12 changes change NNS cord-345222-otfnrarh 416 13 in in IN cord-345222-otfnrarh 416 14 intestinal intestinal JJ cord-345222-otfnrarh 416 15 motility motility NN cord-345222-otfnrarh 416 16 . . . cord-345222-otfnrarh 417 1 Moreover moreover RB cord-345222-otfnrarh 417 2 , , , cord-345222-otfnrarh 417 3 the the DT cord-345222-otfnrarh 417 4 action action NN cord-345222-otfnrarh 417 5 of of IN cord-345222-otfnrarh 417 6 racecadotril racecadotril NNP cord-345222-otfnrarh 417 7 takes take VBZ cord-345222-otfnrarh 417 8 place place NN cord-345222-otfnrarh 417 9 only only RB cord-345222-otfnrarh 417 10 when when WRB cord-345222-otfnrarh 417 11 there there EX cord-345222-otfnrarh 417 12 is be VBZ cord-345222-otfnrarh 417 13 a a DT cord-345222-otfnrarh 417 14 hypersecretion hypersecretion NN cord-345222-otfnrarh 417 15 and and CC cord-345222-otfnrarh 417 16 has have VBZ cord-345222-otfnrarh 417 17 no no DT cord-345222-otfnrarh 417 18 effect effect NN cord-345222-otfnrarh 417 19 on on IN cord-345222-otfnrarh 417 20 the the DT cord-345222-otfnrarh 417 21 activity activity NN cord-345222-otfnrarh 417 22 secretory secretory JJ cord-345222-otfnrarh 417 23 baseline baseline NN cord-345222-otfnrarh 417 24 . . . cord-345222-otfnrarh 418 1 New new JJ cord-345222-otfnrarh 418 2 data datum NNS cord-345222-otfnrarh 418 3 have have VBP cord-345222-otfnrarh 418 4 reconfirmed reconfirm VBN cord-345222-otfnrarh 418 5 that that IN cord-345222-otfnrarh 418 6 racecadotril racecadotril NNP cord-345222-otfnrarh 418 7 is be VBZ cord-345222-otfnrarh 418 8 an an DT cord-345222-otfnrarh 418 9 effective effective JJ cord-345222-otfnrarh 418 10 adjunctive adjunctive JJ cord-345222-otfnrarh 418 11 therapy therapy NN cord-345222-otfnrarh 418 12 to to IN cord-345222-otfnrarh 418 13 oral oral JJ cord-345222-otfnrarh 418 14 rehydration rehydration NN cord-345222-otfnrarh 418 15 in in IN cord-345222-otfnrarh 418 16 watery watery JJ cord-345222-otfnrarh 418 17 diarrhea diarrhea NN cord-345222-otfnrarh 418 18 . . . cord-345222-otfnrarh 419 1 1 1 LS cord-345222-otfnrarh 420 1 A a DT cord-345222-otfnrarh 420 2 recent recent JJ cord-345222-otfnrarh 420 3 individual individual JJ cord-345222-otfnrarh 420 4 patient patient NN cord-345222-otfnrarh 420 5 data datum NNS cord-345222-otfnrarh 420 6 meta meta NNP cord-345222-otfnrarh 420 7 - - HYPH cord-345222-otfnrarh 420 8 analysis analysis NN cord-345222-otfnrarh 420 9 129 129 CD cord-345222-otfnrarh 420 10 assessed assess VBD cord-345222-otfnrarh 420 11 the the DT cord-345222-otfnrarh 420 12 efficacy efficacy NN cord-345222-otfnrarh 420 13 of of IN cord-345222-otfnrarh 420 14 the the DT cord-345222-otfnrarh 420 15 use use NN cord-345222-otfnrarh 420 16 of of IN cord-345222-otfnrarh 420 17 racecadotril racecadotril NNP cord-345222-otfnrarh 420 18 as as IN cord-345222-otfnrarh 420 19 an an DT cord-345222-otfnrarh 420 20 adjunct adjunct NN cord-345222-otfnrarh 420 21 to to IN cord-345222-otfnrarh 420 22 ORS ORS NNP cord-345222-otfnrarh 420 23 compared compare VBN cord-345222-otfnrarh 420 24 with with IN cord-345222-otfnrarh 420 25 ORS ORS NNP cord-345222-otfnrarh 420 26 alone alone RB cord-345222-otfnrarh 420 27 or or CC cord-345222-otfnrarh 420 28 with with IN cord-345222-otfnrarh 420 29 placebo placebo NN cord-345222-otfnrarh 420 30 . . . cord-345222-otfnrarh 421 1 Raw raw JJ cord-345222-otfnrarh 421 2 data datum NNS cord-345222-otfnrarh 421 3 from from IN cord-345222-otfnrarh 421 4 nine nine CD cord-345222-otfnrarh 421 5 RCTs RCTs NNPS cord-345222-otfnrarh 421 6 involving involve VBG cord-345222-otfnrarh 421 7 1348 1348 CD cord-345222-otfnrarh 421 8 children child NNS cord-345222-otfnrarh 421 9 aged age VBN cord-345222-otfnrarh 421 10 1 1 CD cord-345222-otfnrarh 421 11 month month NN cord-345222-otfnrarh 421 12 to to IN cord-345222-otfnrarh 421 13 15 15 CD cord-345222-otfnrarh 421 14 years year NNS cord-345222-otfnrarh 421 15 with with IN cord-345222-otfnrarh 421 16 AGE AGE NNP cord-345222-otfnrarh 421 17 were be VBD cord-345222-otfnrarh 421 18 available available JJ cord-345222-otfnrarh 421 19 for for IN cord-345222-otfnrarh 421 20 the the DT cord-345222-otfnrarh 421 21 analysis analysis NN cord-345222-otfnrarh 421 22 . . . cord-345222-otfnrarh 422 1 Two two CD cord-345222-otfnrarh 422 2 trials trial NNS cord-345222-otfnrarh 422 3 compared compare VBD cord-345222-otfnrarh 422 4 the the DT cord-345222-otfnrarh 422 5 effect effect NN cord-345222-otfnrarh 422 6 of of IN cord-345222-otfnrarh 422 7 racecadotril racecadotril NNP cord-345222-otfnrarh 422 8 with with IN cord-345222-otfnrarh 422 9 placebo placebo NN cord-345222-otfnrarh 422 10 130 130 CD cord-345222-otfnrarh 422 11 , , , cord-345222-otfnrarh 422 12 131 131 CD cord-345222-otfnrarh 422 13 with with IN cord-345222-otfnrarh 422 14 no no DT cord-345222-otfnrarh 422 15 treatment treatment NN cord-345222-otfnrarh 422 16 ( ( -LRB- cord-345222-otfnrarh 422 17 two two CD cord-345222-otfnrarh 422 18 RCTs RCTs NNPS cord-345222-otfnrarh 422 19 ) ) -RRB- cord-345222-otfnrarh 422 20 , , , cord-345222-otfnrarh 422 21 or or CC cord-345222-otfnrarh 422 22 with with IN cord-345222-otfnrarh 422 23 kaolin kaolin NN cord-345222-otfnrarh 422 24 - - HYPH cord-345222-otfnrarh 422 25 pectin pectin NN cord-345222-otfnrarh 422 26 ( ( -LRB- cord-345222-otfnrarh 422 27 two two CD cord-345222-otfnrarh 422 28 RCTs rct NNS cord-345222-otfnrarh 422 29 ) ) -RRB- cord-345222-otfnrarh 422 30 . . . cord-345222-otfnrarh 423 1 Compared compare VBN cord-345222-otfnrarh 423 2 with with IN cord-345222-otfnrarh 423 3 placebo placebo NN cord-345222-otfnrarh 423 4 , , , cord-345222-otfnrarh 423 5 racecadotril racecadotril NNP cord-345222-otfnrarh 423 6 significantly significantly RB cord-345222-otfnrarh 423 7 reduced reduce VBD cord-345222-otfnrarh 423 8 the the DT cord-345222-otfnrarh 423 9 duration duration NN cord-345222-otfnrarh 423 10 of of IN cord-345222-otfnrarh 423 11 diarrhea diarrhea NN cord-345222-otfnrarh 423 12 after after IN cord-345222-otfnrarh 423 13 inclusion inclusion NN cord-345222-otfnrarh 423 14 . . . cord-345222-otfnrarh 424 1 Almost almost RB cord-345222-otfnrarh 424 2 two two CD cord-345222-otfnrarh 424 3 times time NNS cord-345222-otfnrarh 424 4 more more JJR cord-345222-otfnrarh 424 5 patients patient NNS cord-345222-otfnrarh 424 6 recovered recover VBD cord-345222-otfnrarh 424 7 at at IN cord-345222-otfnrarh 424 8 any any DT cord-345222-otfnrarh 424 9 time time NN cord-345222-otfnrarh 424 10 in in IN cord-345222-otfnrarh 424 11 the the DT cord-345222-otfnrarh 424 12 racecadotril racecadotril NNP cord-345222-otfnrarh 424 13 group group NN cord-345222-otfnrarh 424 14 vs vs IN cord-345222-otfnrarh 424 15 the the DT cord-345222-otfnrarh 424 16 placebo placebo NN cord-345222-otfnrarh 424 17 group group NN cord-345222-otfnrarh 424 18 ( ( -LRB- cord-345222-otfnrarh 424 19 P p NN cord-345222-otfnrarh 424 20 , , , cord-345222-otfnrarh 424 21 0.001 0.001 CD cord-345222-otfnrarh 424 22 ) ) -RRB- cord-345222-otfnrarh 424 23 . . . cord-345222-otfnrarh 425 1 There there EX cord-345222-otfnrarh 425 2 were be VBD cord-345222-otfnrarh 425 3 no no DT cord-345222-otfnrarh 425 4 interactions interaction NNS cord-345222-otfnrarh 425 5 between between IN cord-345222-otfnrarh 425 6 treatment treatment NN cord-345222-otfnrarh 425 7 and and CC cord-345222-otfnrarh 425 8 dehydration dehydration NN cord-345222-otfnrarh 425 9 , , , cord-345222-otfnrarh 425 10 rotavirus rotavirus JJ cord-345222-otfnrarh 425 11 infection infection NN cord-345222-otfnrarh 425 12 , , , cord-345222-otfnrarh 425 13 type type NN cord-345222-otfnrarh 425 14 of of IN cord-345222-otfnrarh 425 15 study study NN cord-345222-otfnrarh 425 16 ( ( -LRB- cord-345222-otfnrarh 425 17 outpatient outpatient NN cord-345222-otfnrarh 425 18 / / SYM cord-345222-otfnrarh 425 19 inpatient inpatient NN cord-345222-otfnrarh 425 20 ) ) -RRB- cord-345222-otfnrarh 425 21 , , , cord-345222-otfnrarh 425 22 or or CC cord-345222-otfnrarh 425 23 country country NN cord-345222-otfnrarh 425 24 . . . cord-345222-otfnrarh 426 1 In in IN cord-345222-otfnrarh 426 2 the the DT cord-345222-otfnrarh 426 3 studies study NNS cord-345222-otfnrarh 426 4 evaluating evaluate VBG cord-345222-otfnrarh 426 5 inpatients inpatient NNS cord-345222-otfnrarh 426 6 , , , cord-345222-otfnrarh 426 7 the the DT cord-345222-otfnrarh 426 8 ratio ratio NN cord-345222-otfnrarh 426 9 of of IN cord-345222-otfnrarh 426 10 mean mean JJ cord-345222-otfnrarh 426 11 stool stool NN cord-345222-otfnrarh 426 12 output output NN cord-345222-otfnrarh 426 13 racecadotril racecadotril NNP cord-345222-otfnrarh 426 14 / / SYM cord-345222-otfnrarh 426 15 placebo placebo NN cord-345222-otfnrarh 426 16 was be VBD cord-345222-otfnrarh 426 17 reduced reduce VBN cord-345222-otfnrarh 426 18 ( ( -LRB- cord-345222-otfnrarh 426 19 P p NN cord-345222-otfnrarh 426 20 , , , cord-345222-otfnrarh 426 21 0.001 0.001 CD cord-345222-otfnrarh 426 22 ) ) -RRB- cord-345222-otfnrarh 426 23 . . . cord-345222-otfnrarh 427 1 In in IN cord-345222-otfnrarh 427 2 outpatient outpatient NN cord-345222-otfnrarh 427 3 studies study NNS cord-345222-otfnrarh 427 4 , , , cord-345222-otfnrarh 427 5 the the DT cord-345222-otfnrarh 427 6 number number NN cord-345222-otfnrarh 427 7 of of IN cord-345222-otfnrarh 427 8 diarrheal diarrheal JJ cord-345222-otfnrarh 427 9 stools stool NNS cord-345222-otfnrarh 427 10 was be VBD cord-345222-otfnrarh 427 11 lower low JJR cord-345222-otfnrarh 427 12 in in IN cord-345222-otfnrarh 427 13 the the DT cord-345222-otfnrarh 427 14 racecadotril racecadotril NNP cord-345222-otfnrarh 427 15 group group NN cord-345222-otfnrarh 427 16 ( ( -LRB- cord-345222-otfnrarh 427 17 P p NN cord-345222-otfnrarh 427 18 , , , cord-345222-otfnrarh 427 19 0.001 0.001 CD cord-345222-otfnrarh 427 20 ) ) -RRB- cord-345222-otfnrarh 427 21 . . . cord-345222-otfnrarh 428 1 In in IN cord-345222-otfnrarh 428 2 the the DT cord-345222-otfnrarh 428 3 responder responder NN cord-345222-otfnrarh 428 4 analysis analysis NN cord-345222-otfnrarh 428 5 ( ( -LRB- cord-345222-otfnrarh 428 6 defined define VBN cord-345222-otfnrarh 428 7 as as IN cord-345222-otfnrarh 428 8 a a DT cord-345222-otfnrarh 428 9 duration duration NN cord-345222-otfnrarh 428 10 of of IN cord-345222-otfnrarh 428 11 diarrhea diarrhea NN cord-345222-otfnrarh 428 12 of of IN cord-345222-otfnrarh 428 13 less less JJR cord-345222-otfnrarh 428 14 than than IN cord-345222-otfnrarh 428 15 2 2 CD cord-345222-otfnrarh 428 16 days day NNS cord-345222-otfnrarh 428 17 ) ) -RRB- cord-345222-otfnrarh 428 18 , , , cord-345222-otfnrarh 428 19 the the DT cord-345222-otfnrarh 428 20 proportion proportion NN cord-345222-otfnrarh 428 21 of of IN cord-345222-otfnrarh 428 22 responders responder NNS cord-345222-otfnrarh 428 23 was be VBD cord-345222-otfnrarh 428 24 significantly significantly RB cord-345222-otfnrarh 428 25 higher high JJR cord-345222-otfnrarh 428 26 in in IN cord-345222-otfnrarh 428 27 the the DT cord-345222-otfnrarh 428 28 racecadotril racecadotril NNP cord-345222-otfnrarh 428 29 group group NN cord-345222-otfnrarh 428 30 compared compare VBN cord-345222-otfnrarh 428 31 with with IN cord-345222-otfnrarh 428 32 the the DT cord-345222-otfnrarh 428 33 placebo placebo NN cord-345222-otfnrarh 428 34 group group NN cord-345222-otfnrarh 428 35 . . . cord-345222-otfnrarh 429 1 By by IN cord-345222-otfnrarh 429 2 adjusting adjust VBG cord-345222-otfnrarh 429 3 for for IN cord-345222-otfnrarh 429 4 dehydration dehydration NN cord-345222-otfnrarh 429 5 and and CC cord-345222-otfnrarh 429 6 rotavirus rotavirus NN cord-345222-otfnrarh 429 7 , , , cord-345222-otfnrarh 429 8 the the DT cord-345222-otfnrarh 429 9 absolute absolute JJ cord-345222-otfnrarh 429 10 risk risk NN cord-345222-otfnrarh 429 11 difference difference NN cord-345222-otfnrarh 429 12 was be VBD cord-345222-otfnrarh 429 13 24.7 24.7 CD cord-345222-otfnrarh 429 14 % % NN cord-345222-otfnrarh 429 15 ( ( -LRB- cord-345222-otfnrarh 429 16 95 95 CD cord-345222-otfnrarh 429 17 % % NN cord-345222-otfnrarh 429 18 confidence confidence NN cord-345222-otfnrarh 429 19 interval interval NN cord-345222-otfnrarh 429 20 19.8 19.8 CD cord-345222-otfnrarh 429 21 - - HYPH cord-345222-otfnrarh 429 22 29.7 29.7 CD cord-345222-otfnrarh 429 23 ) ) -RRB- cord-345222-otfnrarh 429 24 , , , cord-345222-otfnrarh 429 25 and and CC cord-345222-otfnrarh 429 26 the the DT cord-345222-otfnrarh 429 27 associated associate VBN cord-345222-otfnrarh 429 28 number number NN cord-345222-otfnrarh 429 29 needed need VBN cord-345222-otfnrarh 429 30 to to TO cord-345222-otfnrarh 429 31 treat treat VB cord-345222-otfnrarh 429 32 was be VBD cord-345222-otfnrarh 429 33 four four CD cord-345222-otfnrarh 429 34 . . . cord-345222-otfnrarh 430 1 The the DT cord-345222-otfnrarh 430 2 secondary secondary JJ cord-345222-otfnrarh 430 3 need need NN cord-345222-otfnrarh 430 4 for for IN cord-345222-otfnrarh 430 5 care care NN cord-345222-otfnrarh 430 6 in in IN cord-345222-otfnrarh 430 7 outpatients outpatient NNS cord-345222-otfnrarh 430 8 was be VBD cord-345222-otfnrarh 430 9 significantly significantly RB cord-345222-otfnrarh 430 10 in in IN cord-345222-otfnrarh 430 11 favor favor NN cord-345222-otfnrarh 430 12 of of IN cord-345222-otfnrarh 430 13 racecadotril racecadotril NNP cord-345222-otfnrarh 430 14 in in IN cord-345222-otfnrarh 430 15 two two CD cord-345222-otfnrarh 430 16 studies study NNS cord-345222-otfnrarh 430 17 . . . cord-345222-otfnrarh 431 1 Also also RB cord-345222-otfnrarh 431 2 , , , cord-345222-otfnrarh 431 3 the the DT cord-345222-otfnrarh 431 4 need need NN cord-345222-otfnrarh 431 5 for for IN cord-345222-otfnrarh 431 6 IVT IVT NNP cord-345222-otfnrarh 431 7 was be VBD cord-345222-otfnrarh 431 8 lower low JJR cord-345222-otfnrarh 431 9 in in IN cord-345222-otfnrarh 431 10 the the DT cord-345222-otfnrarh 431 11 racecadotril racecadotril NNP cord-345222-otfnrarh 431 12 group group NN cord-345222-otfnrarh 431 13 compared compare VBN cord-345222-otfnrarh 431 14 with with IN cord-345222-otfnrarh 431 15 the the DT cord-345222-otfnrarh 431 16 placebo placebo NN cord-345222-otfnrarh 431 17 group group NN cord-345222-otfnrarh 431 18 . . . cord-345222-otfnrarh 432 1 There there EX cord-345222-otfnrarh 432 2 was be VBD cord-345222-otfnrarh 432 3 no no DT cord-345222-otfnrarh 432 4 difference difference NN cord-345222-otfnrarh 432 5 in in IN cord-345222-otfnrarh 432 6 the the DT cord-345222-otfnrarh 432 7 incidence incidence NN cord-345222-otfnrarh 432 8 of of IN cord-345222-otfnrarh 432 9 adverse adverse JJ cord-345222-otfnrarh 432 10 events event NNS cord-345222-otfnrarh 432 11 between between IN cord-345222-otfnrarh 432 12 the the DT cord-345222-otfnrarh 432 13 groups group NNS cord-345222-otfnrarh 432 14 . . . cord-345222-otfnrarh 433 1 The the DT cord-345222-otfnrarh 433 2 results result NNS cord-345222-otfnrarh 433 3 of of IN cord-345222-otfnrarh 433 4 this this DT cord-345222-otfnrarh 433 5 recent recent JJ cord-345222-otfnrarh 433 6 meta meta JJ cord-345222-otfnrarh 433 7 - - HYPH cord-345222-otfnrarh 433 8 analysis analysis NN cord-345222-otfnrarh 433 9 support support VBP cord-345222-otfnrarh 433 10 the the DT cord-345222-otfnrarh 433 11 use use NN cord-345222-otfnrarh 433 12 of of IN cord-345222-otfnrarh 433 13 racecadotril racecadotril NNP cord-345222-otfnrarh 433 14 as as IN cord-345222-otfnrarh 433 15 an an DT cord-345222-otfnrarh 433 16 adjunct adjunct NN cord-345222-otfnrarh 433 17 to to IN cord-345222-otfnrarh 433 18 ORS ORS NNP cord-345222-otfnrarh 433 19 for for IN cord-345222-otfnrarh 433 20 the the DT cord-345222-otfnrarh 433 21 management management NN cord-345222-otfnrarh 433 22 of of IN cord-345222-otfnrarh 433 23 AGE AGE NNP cord-345222-otfnrarh 433 24 in in IN cord-345222-otfnrarh 433 25 children child NNS cord-345222-otfnrarh 433 26 . . . cord-345222-otfnrarh 434 1 In in IN cord-345222-otfnrarh 434 2 addition addition NN cord-345222-otfnrarh 434 3 , , , cord-345222-otfnrarh 434 4 the the DT cord-345222-otfnrarh 434 5 safety safety NN cord-345222-otfnrarh 434 6 of of IN cord-345222-otfnrarh 434 7 racecadotril racecadotril NNP cord-345222-otfnrarh 434 8 in in IN cord-345222-otfnrarh 434 9 children child NNS cord-345222-otfnrarh 434 10 has have VBZ cord-345222-otfnrarh 434 11 been be VBN cord-345222-otfnrarh 434 12 demonstrated demonstrate VBN cord-345222-otfnrarh 434 13 in in IN cord-345222-otfnrarh 434 14 clinical clinical JJ cord-345222-otfnrarh 434 15 studies study NNS cord-345222-otfnrarh 434 16 , , , cord-345222-otfnrarh 434 17 including include VBG cord-345222-otfnrarh 434 18 a a DT cord-345222-otfnrarh 434 19 large large JJ cord-345222-otfnrarh 434 20 pre pre AFX cord-345222-otfnrarh 434 21 - - NN cord-345222-otfnrarh 434 22 and and CC cord-345222-otfnrarh 434 23 postaccess postaccess JJ cord-345222-otfnrarh 434 24 study study NN cord-345222-otfnrarh 434 25 showing show VBG cord-345222-otfnrarh 434 26 that that IN cord-345222-otfnrarh 434 27 racecadotril racecadotril NNP cord-345222-otfnrarh 434 28 has have VBZ cord-345222-otfnrarh 434 29 a a DT cord-345222-otfnrarh 434 30 favorable favorable JJ cord-345222-otfnrarh 434 31 adverse adverse JJ cord-345222-otfnrarh 434 32 - - HYPH cord-345222-otfnrarh 434 33 event event NN cord-345222-otfnrarh 434 34 profile profile NN cord-345222-otfnrarh 434 35 in in IN cord-345222-otfnrarh 434 36 children child NNS cord-345222-otfnrarh 434 37 . . . cord-345222-otfnrarh 435 1 [ [ -LRB- cord-345222-otfnrarh 435 2 128 128 CD cord-345222-otfnrarh 435 3 ] ] -RRB- cord-345222-otfnrarh 435 4 [ [ -LRB- cord-345222-otfnrarh 435 5 129 129 CD cord-345222-otfnrarh 435 6 ] ] -RRB- cord-345222-otfnrarh 435 7 [ [ -LRB- cord-345222-otfnrarh 435 8 130 130 CD cord-345222-otfnrarh 435 9 ] ] -RRB- cord-345222-otfnrarh 436 1 Despite despite IN cord-345222-otfnrarh 436 2 racecadotril racecadotril NNP cord-345222-otfnrarh 436 3 's 's POS cord-345222-otfnrarh 436 4 proven prove VBN cord-345222-otfnrarh 436 5 safety safety NN cord-345222-otfnrarh 436 6 and and CC cord-345222-otfnrarh 436 7 efficacy efficacy NN cord-345222-otfnrarh 436 8 in in IN cord-345222-otfnrarh 436 9 treating treat VBG cord-345222-otfnrarh 436 10 acute acute JJ cord-345222-otfnrarh 436 11 watery watery JJ cord-345222-otfnrarh 436 12 diarrhea diarrhea NN cord-345222-otfnrarh 436 13 , , , cord-345222-otfnrarh 436 14 its -PRON- PRP$ cord-345222-otfnrarh 436 15 cost cost NN cord-345222-otfnrarh 436 16 - - HYPH cord-345222-otfnrarh 436 17 effectiveness effectiveness NN cord-345222-otfnrarh 436 18 for for IN cord-345222-otfnrarh 436 19 infants infant NNS cord-345222-otfnrarh 436 20 and and CC cord-345222-otfnrarh 436 21 children child NNS cord-345222-otfnrarh 436 22 has have VBZ cord-345222-otfnrarh 436 23 not not RB cord-345222-otfnrarh 436 24 yet yet RB cord-345222-otfnrarh 436 25 been be VBN cord-345222-otfnrarh 436 26 determined determine VBN cord-345222-otfnrarh 436 27 in in IN cord-345222-otfnrarh 436 28 Europe Europe NNP cord-345222-otfnrarh 436 29 . . . cord-345222-otfnrarh 437 1 128 128 CD cord-345222-otfnrarh 438 1 The the DT cord-345222-otfnrarh 438 2 UK UK NNP cord-345222-otfnrarh 438 3 model model NN cord-345222-otfnrarh 438 4 highlights highlight VBZ cord-345222-otfnrarh 438 5 the the DT cord-345222-otfnrarh 438 6 potential potential JJ cord-345222-otfnrarh 438 7 savings saving NNS cord-345222-otfnrarh 438 8 arising arise VBG cord-345222-otfnrarh 438 9 from from IN cord-345222-otfnrarh 438 10 reduction reduction NN cord-345222-otfnrarh 438 11 in in IN cord-345222-otfnrarh 438 12 diarrhea diarrhea JJ cord-345222-otfnrarh 438 13 duration duration NN cord-345222-otfnrarh 438 14 and and CC cord-345222-otfnrarh 438 15 avoidance avoidance NN cord-345222-otfnrarh 438 16 of of IN cord-345222-otfnrarh 438 17 reconsultation reconsultation NN cord-345222-otfnrarh 438 18 and and CC cord-345222-otfnrarh 438 19 referral referral NN cord-345222-otfnrarh 438 20 rates rate NNS cord-345222-otfnrarh 438 21 in in IN cord-345222-otfnrarh 438 22 children child NNS cord-345222-otfnrarh 438 23 with with IN cord-345222-otfnrarh 438 24 diarrhea diarrhea NN cord-345222-otfnrarh 438 25 . . . cord-345222-otfnrarh 439 1 128 128 CD cord-345222-otfnrarh 439 2 Children child NNS cord-345222-otfnrarh 439 3 presenting present VBG cord-345222-otfnrarh 439 4 with with IN cord-345222-otfnrarh 439 5 AGE AGE NNP cord-345222-otfnrarh 439 6 often often RB cord-345222-otfnrarh 439 7 have have VBP cord-345222-otfnrarh 439 8 high high JJ cord-345222-otfnrarh 439 9 levels level NNS cord-345222-otfnrarh 439 10 of of IN cord-345222-otfnrarh 439 11 vomiting vomiting NN cord-345222-otfnrarh 439 12 that that WDT cord-345222-otfnrarh 439 13 can can MD cord-345222-otfnrarh 439 14 interfere interfere VB cord-345222-otfnrarh 439 15 with with IN cord-345222-otfnrarh 439 16 the the DT cord-345222-otfnrarh 439 17 oral oral JJ cord-345222-otfnrarh 439 18 rehydration rehydration NN cord-345222-otfnrarh 439 19 process process NN cord-345222-otfnrarh 439 20 , , , cord-345222-otfnrarh 439 21 which which WDT cord-345222-otfnrarh 439 22 could could MD cord-345222-otfnrarh 439 23 limit limit VB cord-345222-otfnrarh 439 24 the the DT cord-345222-otfnrarh 439 25 success success NN cord-345222-otfnrarh 439 26 of of IN cord-345222-otfnrarh 439 27 the the DT cord-345222-otfnrarh 439 28 oral oral JJ cord-345222-otfnrarh 439 29 therapy therapy NN cord-345222-otfnrarh 439 30 . . . cord-345222-otfnrarh 440 1 Ondansetron Ondansetron NNP cord-345222-otfnrarh 440 2 is be VBZ cord-345222-otfnrarh 440 3 widely widely RB cord-345222-otfnrarh 440 4 used use VBN cord-345222-otfnrarh 440 5 in in IN cord-345222-otfnrarh 440 6 the the DT cord-345222-otfnrarh 440 7 pediatric pediatric JJ cord-345222-otfnrarh 440 8 emergency emergency NN cord-345222-otfnrarh 440 9 department department NN cord-345222-otfnrarh 440 10 for for IN cord-345222-otfnrarh 440 11 vomiting vomiting NN cord-345222-otfnrarh 440 12 and and CC cord-345222-otfnrarh 440 13 AGE age NN cord-345222-otfnrarh 440 14 ; ; : cord-345222-otfnrarh 440 15 it -PRON- PRP cord-345222-otfnrarh 440 16 can can MD cord-345222-otfnrarh 440 17 help help VB cord-345222-otfnrarh 440 18 with with IN cord-345222-otfnrarh 440 19 the the DT cord-345222-otfnrarh 440 20 successful successful JJ cord-345222-otfnrarh 440 21 delivery delivery NN cord-345222-otfnrarh 440 22 of of IN cord-345222-otfnrarh 440 23 ORT ORT NNP cord-345222-otfnrarh 440 24 , , , cord-345222-otfnrarh 440 25 thereby thereby RB cord-345222-otfnrarh 440 26 reducing reduce VBG cord-345222-otfnrarh 440 27 the the DT cord-345222-otfnrarh 440 28 need need NN cord-345222-otfnrarh 440 29 to to TO cord-345222-otfnrarh 440 30 treat treat VB cord-345222-otfnrarh 440 31 with with IN cord-345222-otfnrarh 440 32 IVT IVT NNP cord-345222-otfnrarh 440 33 . . . cord-345222-otfnrarh 441 1 A a DT cord-345222-otfnrarh 441 2 recent recent JJ cord-345222-otfnrarh 441 3 study study NN cord-345222-otfnrarh 441 4 evaluated evaluate VBD cord-345222-otfnrarh 441 5 the the DT cord-345222-otfnrarh 441 6 spectrum spectrum NN cord-345222-otfnrarh 441 7 of of IN cord-345222-otfnrarh 441 8 diagnoses diagnosis NNS cord-345222-otfnrarh 441 9 for for IN cord-345222-otfnrarh 441 10 which which WDT cord-345222-otfnrarh 441 11 ondansetron ondansetron WDT cord-345222-otfnrarh 441 12 is be VBZ cord-345222-otfnrarh 441 13 used use VBN cord-345222-otfnrarh 441 14 in in IN cord-345222-otfnrarh 441 15 the the DT cord-345222-otfnrarh 441 16 pediatric pediatric JJ cord-345222-otfnrarh 441 17 emergency emergency NN cord-345222-otfnrarh 441 18 room room NN cord-345222-otfnrarh 441 19 . . . cord-345222-otfnrarh 442 1 Medical medical JJ cord-345222-otfnrarh 442 2 records record NNS cord-345222-otfnrarh 442 3 of of IN cord-345222-otfnrarh 442 4 patients patient NNS cord-345222-otfnrarh 442 5 3 3 CD cord-345222-otfnrarh 442 6 months month NNS cord-345222-otfnrarh 442 7 to to IN cord-345222-otfnrarh 442 8 18 18 CD cord-345222-otfnrarh 442 9 years year NNS cord-345222-otfnrarh 442 10 of of IN cord-345222-otfnrarh 442 11 age age NN cord-345222-otfnrarh 442 12 given give VBN cord-345222-otfnrarh 442 13 ondansetron ondansetron VBD cord-345222-otfnrarh 442 14 for for IN cord-345222-otfnrarh 442 15 2 2 CD cord-345222-otfnrarh 442 16 years year NNS cord-345222-otfnrarh 442 17 were be VBD cord-345222-otfnrarh 442 18 retrospectively retrospectively RB cord-345222-otfnrarh 442 19 reviewed review VBN cord-345222-otfnrarh 442 20 . . . cord-345222-otfnrarh 443 1 Patients patient NNS cord-345222-otfnrarh 443 2 without without IN cord-345222-otfnrarh 443 3 a a DT cord-345222-otfnrarh 443 4 primary primary JJ cord-345222-otfnrarh 443 5 discharge discharge NN cord-345222-otfnrarh 443 6 diagnosis diagnosis NN cord-345222-otfnrarh 443 7 of of IN cord-345222-otfnrarh 443 8 vomiting vomiting NN cord-345222-otfnrarh 443 9 or or CC cord-345222-otfnrarh 443 10 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 443 11 were be VBD cord-345222-otfnrarh 443 12 defined define VBN cord-345222-otfnrarh 443 13 as as IN cord-345222-otfnrarh 443 14 non non JJ cord-345222-otfnrarh 443 15 - - JJ cord-345222-otfnrarh 443 16 gastroenteritis gastroenteritis JJ cord-345222-otfnrarh 443 17 , , , cord-345222-otfnrarh 443 18 and and CC cord-345222-otfnrarh 443 19 they -PRON- PRP cord-345222-otfnrarh 443 20 were be VBD cord-345222-otfnrarh 443 21 compared compare VBN cord-345222-otfnrarh 443 22 to to IN cord-345222-otfnrarh 443 23 the the DT cord-345222-otfnrarh 443 24 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 443 25 group group NN cord-345222-otfnrarh 443 26 . . . cord-345222-otfnrarh 444 1 The the DT cord-345222-otfnrarh 444 2 non non JJ cord-345222-otfnrarh 444 3 - - JJ cord-345222-otfnrarh 444 4 gastroenteritis gastroenteritis JJ cord-345222-otfnrarh 444 5 group group NN cord-345222-otfnrarh 444 6 includes include VBZ cord-345222-otfnrarh 444 7 38 38 CD cord-345222-otfnrarh 444 8 % % NN cord-345222-otfnrarh 444 9 of of IN cord-345222-otfnrarh 444 10 the the DT cord-345222-otfnrarh 444 11 subjects subject NNS cord-345222-otfnrarh 444 12 , , , cord-345222-otfnrarh 444 13 and and CC cord-345222-otfnrarh 444 14 they -PRON- PRP cord-345222-otfnrarh 444 15 were be VBD cord-345222-otfnrarh 444 16 older old JJR cord-345222-otfnrarh 444 17 ( ( -LRB- cord-345222-otfnrarh 444 18 8.3 8.3 CD cord-345222-otfnrarh 444 19 vs vs IN cord-345222-otfnrarh 444 20 4.3 4.3 CD cord-345222-otfnrarh 444 21 years year NNS cord-345222-otfnrarh 444 22 ) ) -RRB- cord-345222-otfnrarh 444 23 than than IN cord-345222-otfnrarh 444 24 the the DT cord-345222-otfnrarh 444 25 gastroenteritis gastroenteritis JJ cord-345222-otfnrarh 444 26 patients patient NNS cord-345222-otfnrarh 444 27 . . . cord-345222-otfnrarh 445 1 The the DT cord-345222-otfnrarh 445 2 most most RBS cord-345222-otfnrarh 445 3 common common JJ cord-345222-otfnrarh 445 4 primary primary JJ cord-345222-otfnrarh 445 5 diagnoses diagnosis NNS cord-345222-otfnrarh 445 6 for for IN cord-345222-otfnrarh 445 7 non non JJ cord-345222-otfnrarh 445 8 - - JJ cord-345222-otfnrarh 445 9 gastroenteritis gastroenteritis JJ cord-345222-otfnrarh 445 10 discharged discharge VBN cord-345222-otfnrarh 445 11 patients patient NNS cord-345222-otfnrarh 445 12 were be VBD cord-345222-otfnrarh 445 13 fever fever NN cord-345222-otfnrarh 445 14 ( ( -LRB- cord-345222-otfnrarh 445 15 15 15 CD cord-345222-otfnrarh 445 16 % % NN cord-345222-otfnrarh 445 17 ) ) -RRB- cord-345222-otfnrarh 445 18 , , , cord-345222-otfnrarh 445 19 abdominal abdominal JJ cord-345222-otfnrarh 445 20 pain/ pain/ CD cord-345222-otfnrarh 445 21 tenderness tenderness NN cord-345222-otfnrarh 445 22 ( ( -LRB- cord-345222-otfnrarh 445 23 13 13 CD cord-345222-otfnrarh 445 24 % % NN cord-345222-otfnrarh 445 25 ) ) -RRB- cord-345222-otfnrarh 445 26 , , , cord-345222-otfnrarh 445 27 head head NN cord-345222-otfnrarh 445 28 injury injury NN cord-345222-otfnrarh 445 29 / / SYM cord-345222-otfnrarh 445 30 concussion concussion NN cord-345222-otfnrarh 445 31 ( ( -LRB- cord-345222-otfnrarh 445 32 7 7 CD cord-345222-otfnrarh 445 33 % % NN cord-345222-otfnrarh 445 34 ) ) -RRB- cord-345222-otfnrarh 445 35 , , , cord-345222-otfnrarh 445 36 pharyngitis pharyngitis NN cord-345222-otfnrarh 445 37 ( ( -LRB- cord-345222-otfnrarh 445 38 6 6 CD cord-345222-otfnrarh 445 39 % % NN cord-345222-otfnrarh 445 40 ) ) -RRB- cord-345222-otfnrarh 445 41 , , , cord-345222-otfnrarh 445 42 viral viral JJ cord-345222-otfnrarh 445 43 infection infection NN cord-345222-otfnrarh 445 44 ( ( -LRB- cord-345222-otfnrarh 445 45 6 6 CD cord-345222-otfnrarh 445 46 % % NN cord-345222-otfnrarh 445 47 ) ) -RRB- cord-345222-otfnrarh 445 48 , , , cord-345222-otfnrarh 445 49 migraine migraine NN cord-345222-otfnrarh 445 50 variants variant NNS cord-345222-otfnrarh 445 51 ( ( -LRB- cord-345222-otfnrarh 445 52 5 5 CD cord-345222-otfnrarh 445 53 % % NN cord-345222-otfnrarh 445 54 ) ) -RRB- cord-345222-otfnrarh 445 55 , , , cord-345222-otfnrarh 445 56 and and CC cord-345222-otfnrarh 445 57 otitis otitis NN cord-345222-otfnrarh 445 58 media medium NNS cord-345222-otfnrarh 445 59 ( ( -LRB- cord-345222-otfnrarh 445 60 5 5 CD cord-345222-otfnrarh 445 61 % % NN cord-345222-otfnrarh 445 62 ) ) -RRB- cord-345222-otfnrarh 445 63 . . . cord-345222-otfnrarh 446 1 Although although IN cord-345222-otfnrarh 446 2 ondansetron ondansetron NNP cord-345222-otfnrarh 446 3 is be VBZ cord-345222-otfnrarh 446 4 a a DT cord-345222-otfnrarh 446 5 widely widely RB cord-345222-otfnrarh 446 6 accepted accept VBN cord-345222-otfnrarh 446 7 treatment treatment NN cord-345222-otfnrarh 446 8 for for IN cord-345222-otfnrarh 446 9 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 446 10 submit submit VBP cord-345222-otfnrarh 446 11 your -PRON- PRP$ cord-345222-otfnrarh 446 12 manuscript manuscript NN cord-345222-otfnrarh 446 13 | | NNP cord-345222-otfnrarh 446 14 www.dovepress.com www.dovepress.com NN cord-345222-otfnrarh 446 15 in in IN cord-345222-otfnrarh 446 16 children child NNS cord-345222-otfnrarh 447 1 -62 -62 NN cord-345222-otfnrarh 447 2 % % NN cord-345222-otfnrarh 447 3 of of IN cord-345222-otfnrarh 447 4 total total JJ cord-345222-otfnrarh 447 5 use use NN cord-345222-otfnrarh 447 6 -this -this NNP cord-345222-otfnrarh 447 7 study study NN cord-345222-otfnrarh 447 8 identifies identify VBZ cord-345222-otfnrarh 447 9 a a DT cord-345222-otfnrarh 447 10 broader broad JJR cord-345222-otfnrarh 447 11 spectrum spectrum NN cord-345222-otfnrarh 447 12 of of IN cord-345222-otfnrarh 447 13 primary primary JJ cord-345222-otfnrarh 447 14 diagnoses diagnosis NNS cord-345222-otfnrarh 447 15 for for IN cord-345222-otfnrarh 447 16 which which WDT cord-345222-otfnrarh 447 17 ondansetron ondansetron WDT cord-345222-otfnrarh 447 18 is be VBZ cord-345222-otfnrarh 447 19 being be VBG cord-345222-otfnrarh 447 20 used use VBN cord-345222-otfnrarh 447 21 . . . cord-345222-otfnrarh 448 1 132 132 CD cord-345222-otfnrarh 449 1 Another another DT cord-345222-otfnrarh 449 2 study study NN cord-345222-otfnrarh 449 3 used use VBD cord-345222-otfnrarh 449 4 RCTs RCTs NNP cord-345222-otfnrarh 449 5 comparing compare VBG cord-345222-otfnrarh 449 6 antiemetics antiemetic NNS cord-345222-otfnrarh 449 7 with with IN cord-345222-otfnrarh 449 8 placebo placebo NN cord-345222-otfnrarh 449 9 or or CC cord-345222-otfnrarh 449 10 no no DT cord-345222-otfnrarh 449 11 treatment treatment NN cord-345222-otfnrarh 449 12 in in IN cord-345222-otfnrarh 449 13 children child NNS cord-345222-otfnrarh 449 14 and and CC cord-345222-otfnrarh 449 15 adolescents adolescent NNS cord-345222-otfnrarh 449 16 under under IN cord-345222-otfnrarh 449 17 the the DT cord-345222-otfnrarh 449 18 age age NN cord-345222-otfnrarh 449 19 of of IN cord-345222-otfnrarh 449 20 18 18 CD cord-345222-otfnrarh 449 21 years year NNS cord-345222-otfnrarh 449 22 , , , cord-345222-otfnrarh 449 23 for for IN cord-345222-otfnrarh 449 24 vomiting vomit VBG cord-345222-otfnrarh 449 25 due due IN cord-345222-otfnrarh 449 26 to to IN cord-345222-otfnrarh 449 27 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 449 28 . . . cord-345222-otfnrarh 450 1 The the DT cord-345222-otfnrarh 450 2 proportion proportion NN cord-345222-otfnrarh 450 3 of of IN cord-345222-otfnrarh 450 4 patients patient NNS cord-345222-otfnrarh 450 5 with with IN cord-345222-otfnrarh 450 6 cessation cessation NN cord-345222-otfnrarh 450 7 of of IN cord-345222-otfnrarh 450 8 vomiting vomit VBG cord-345222-otfnrarh 450 9 in in IN cord-345222-otfnrarh 450 10 24 24 CD cord-345222-otfnrarh 450 11 hours hour NNS cord-345222-otfnrarh 450 12 was be VBD cord-345222-otfnrarh 450 13 58 58 CD cord-345222-otfnrarh 450 14 % % NN cord-345222-otfnrarh 450 15 with with IN cord-345222-otfnrarh 450 16 intravenous intravenous JJ cord-345222-otfnrarh 450 17 ondansetron ondansetron NN cord-345222-otfnrarh 450 18 , , , cord-345222-otfnrarh 450 19 17 17 CD cord-345222-otfnrarh 450 20 % % NN cord-345222-otfnrarh 450 21 placebo placebo NN cord-345222-otfnrarh 450 22 , , , cord-345222-otfnrarh 450 23 and and CC cord-345222-otfnrarh 450 24 33 33 CD cord-345222-otfnrarh 450 25 % % NN cord-345222-otfnrarh 450 26 in in IN cord-345222-otfnrarh 450 27 the the DT cord-345222-otfnrarh 450 28 metoclopramide metoclopramide NNP cord-345222-otfnrarh 450 29 group group NN cord-345222-otfnrarh 450 30 ( ( -LRB- cord-345222-otfnrarh 450 31 P p NN cord-345222-otfnrarh 450 32 = = SYM cord-345222-otfnrarh 450 33 0.039 0.039 CD cord-345222-otfnrarh 450 34 ) ) -RRB- cord-345222-otfnrarh 450 35 . . . cord-345222-otfnrarh 451 1 In in IN cord-345222-otfnrarh 451 2 this this DT cord-345222-otfnrarh 451 3 case case NN cord-345222-otfnrarh 451 4 , , , cord-345222-otfnrarh 451 5 the the DT cord-345222-otfnrarh 451 6 authors author NNS cord-345222-otfnrarh 451 7 ' ' POS cord-345222-otfnrarh 451 8 conclusions conclusion NNS cord-345222-otfnrarh 451 9 were be VBD cord-345222-otfnrarh 451 10 that that DT cord-345222-otfnrarh 451 11 oral oral JJ cord-345222-otfnrarh 451 12 ondansetron ondansetron NN cord-345222-otfnrarh 451 13 increased increase VBD cord-345222-otfnrarh 451 14 the the DT cord-345222-otfnrarh 451 15 proportion proportion NN cord-345222-otfnrarh 451 16 of of IN cord-345222-otfnrarh 451 17 patients patient NNS cord-345222-otfnrarh 451 18 who who WP cord-345222-otfnrarh 451 19 had have VBD cord-345222-otfnrarh 451 20 ceased cease VBN cord-345222-otfnrarh 451 21 vomiting vomit VBG cord-345222-otfnrarh 451 22 and and CC cord-345222-otfnrarh 451 23 reduced reduce VBD cord-345222-otfnrarh 451 24 the the DT cord-345222-otfnrarh 451 25 number number NN cord-345222-otfnrarh 451 26 needing need VBG cord-345222-otfnrarh 451 27 intravenous intravenous JJ cord-345222-otfnrarh 451 28 rehydration rehydration NN cord-345222-otfnrarh 451 29 and and CC cord-345222-otfnrarh 451 30 so so RB cord-345222-otfnrarh 451 31 immediate immediate JJ cord-345222-otfnrarh 451 32 hospital hospital NN cord-345222-otfnrarh 451 33 admissions admission NNS cord-345222-otfnrarh 451 34 . . . cord-345222-otfnrarh 452 1 1 1 CD cord-345222-otfnrarh 452 2 , , , cord-345222-otfnrarh 453 1 133 133 CD cord-345222-otfnrarh 454 1 Today today NN cord-345222-otfnrarh 454 2 , , , cord-345222-otfnrarh 454 3 it -PRON- PRP cord-345222-otfnrarh 454 4 is be VBZ cord-345222-otfnrarh 454 5 still still RB cord-345222-otfnrarh 454 6 unclear unclear JJ cord-345222-otfnrarh 454 7 if if IN cord-345222-otfnrarh 454 8 in in IN cord-345222-otfnrarh 454 9 spite spite NN cord-345222-otfnrarh 454 10 of of IN cord-345222-otfnrarh 454 11 an an DT cord-345222-otfnrarh 454 12 improvement improvement NN cord-345222-otfnrarh 454 13 in in IN cord-345222-otfnrarh 454 14 the the DT cord-345222-otfnrarh 454 15 vomiting vomiting NN cord-345222-otfnrarh 454 16 , , , cord-345222-otfnrarh 454 17 ondansetron ondansetron RB cord-345222-otfnrarh 454 18 worsens worsen VBZ cord-345222-otfnrarh 454 19 diarrhea diarrhea NN cord-345222-otfnrarh 454 20 . . . cord-345222-otfnrarh 455 1 Some some DT cord-345222-otfnrarh 455 2 trials trial NNS cord-345222-otfnrarh 455 3 report report VBP cord-345222-otfnrarh 455 4 a a DT cord-345222-otfnrarh 455 5 statistically statistically RB cord-345222-otfnrarh 455 6 significant significant JJ cord-345222-otfnrarh 455 7 increase increase NN cord-345222-otfnrarh 455 8 in in IN cord-345222-otfnrarh 455 9 its -PRON- PRP$ cord-345222-otfnrarh 455 10 frequency frequency NN cord-345222-otfnrarh 455 11 as as IN cord-345222-otfnrarh 455 12 an an DT cord-345222-otfnrarh 455 13 adverse adverse JJ cord-345222-otfnrarh 455 14 event event NN cord-345222-otfnrarh 455 15 . . . cord-345222-otfnrarh 456 1 In in IN cord-345222-otfnrarh 456 2 Cochrane Cochrane NNP cord-345222-otfnrarh 456 3 reviews review NNS cord-345222-otfnrarh 456 4 , , , cord-345222-otfnrarh 456 5 diarrhea diarrhea NN cord-345222-otfnrarh 456 6 was be VBD cord-345222-otfnrarh 456 7 reported report VBN cord-345222-otfnrarh 456 8 as as IN cord-345222-otfnrarh 456 9 a a DT cord-345222-otfnrarh 456 10 side side NN cord-345222-otfnrarh 456 11 effect effect NN cord-345222-otfnrarh 456 12 in in IN cord-345222-otfnrarh 456 13 four four CD cord-345222-otfnrarh 456 14 of of IN cord-345222-otfnrarh 456 15 the the DT cord-345222-otfnrarh 456 16 five five CD cord-345222-otfnrarh 456 17 ondansetron ondansetron NNP cord-345222-otfnrarh 456 18 studies study NNS cord-345222-otfnrarh 456 19 . . . cord-345222-otfnrarh 457 1 [ [ -LRB- cord-345222-otfnrarh 457 2 133 133 CD cord-345222-otfnrarh 457 3 ] ] -RRB- cord-345222-otfnrarh 457 4 [ [ -LRB- cord-345222-otfnrarh 457 5 134 134 CD cord-345222-otfnrarh 457 6 ] ] -RRB- cord-345222-otfnrarh 458 1 [ [ -LRB- cord-345222-otfnrarh 458 2 135 135 CD cord-345222-otfnrarh 458 3 ] ] -RRB- cord-345222-otfnrarh 459 1 According accord VBG cord-345222-otfnrarh 459 2 to to IN cord-345222-otfnrarh 459 3 WHO WHO NNP cord-345222-otfnrarh 459 4 , , , cord-345222-otfnrarh 459 5 of of IN cord-345222-otfnrarh 459 6 the the DT cord-345222-otfnrarh 459 7 antiemetics antiemetic NNS cord-345222-otfnrarh 459 8 available available JJ cord-345222-otfnrarh 459 9 , , , cord-345222-otfnrarh 459 10 those those DT cord-345222-otfnrarh 459 11 with with IN cord-345222-otfnrarh 459 12 the the DT cord-345222-otfnrarh 459 13 greatest great JJS cord-345222-otfnrarh 459 14 evidence evidence NN cord-345222-otfnrarh 459 15 of of IN cord-345222-otfnrarh 459 16 efficacy efficacy NN cord-345222-otfnrarh 459 17 in in IN cord-345222-otfnrarh 459 18 the the DT cord-345222-otfnrarh 459 19 prevention prevention NN cord-345222-otfnrarh 459 20 of of IN cord-345222-otfnrarh 459 21 nausea nausea NN cord-345222-otfnrarh 459 22 and and CC cord-345222-otfnrarh 459 23 vomiting vomiting NN cord-345222-otfnrarh 459 24 ( ( -LRB- cord-345222-otfnrarh 459 25 particularly particularly RB cord-345222-otfnrarh 459 26 in in IN cord-345222-otfnrarh 459 27 the the DT cord-345222-otfnrarh 459 28 treatment treatment NN cord-345222-otfnrarh 459 29 of of IN cord-345222-otfnrarh 459 30 postsurgery postsurgery NN cord-345222-otfnrarh 459 31 nausea nausea NN cord-345222-otfnrarh 459 32 and and CC cord-345222-otfnrarh 459 33 vomiting vomiting NN cord-345222-otfnrarh 459 34 ) ) -RRB- cord-345222-otfnrarh 459 35 were be VBD cord-345222-otfnrarh 459 36 ondansetron ondansetron VBN cord-345222-otfnrarh 459 37 and and CC cord-345222-otfnrarh 459 38 dexamethasone dexamethasone NN cord-345222-otfnrarh 459 39 , , , cord-345222-otfnrarh 459 40 ondansetron ondansetron VBD cord-345222-otfnrarh 459 41 as as IN cord-345222-otfnrarh 459 42 first first JJ cord-345222-otfnrarh 459 43 - - HYPH cord-345222-otfnrarh 459 44 line line NN cord-345222-otfnrarh 459 45 treatment treatment NN cord-345222-otfnrarh 459 46 with with IN cord-345222-otfnrarh 459 47 the the DT cord-345222-otfnrarh 459 48 addition addition NN cord-345222-otfnrarh 459 49 of of IN cord-345222-otfnrarh 459 50 dexamethasone dexamethasone NN cord-345222-otfnrarh 459 51 as as IN cord-345222-otfnrarh 459 52 required require VBN cord-345222-otfnrarh 459 53 . . . cord-345222-otfnrarh 460 1 136 136 CD cord-345222-otfnrarh 460 2 _SP cord-345222-otfnrarh 460 3 Zinc Zinc NNP cord-345222-otfnrarh 460 4 is be VBZ cord-345222-otfnrarh 460 5 an an DT cord-345222-otfnrarh 460 6 important important JJ cord-345222-otfnrarh 460 7 trace trace NN cord-345222-otfnrarh 460 8 element element NN cord-345222-otfnrarh 460 9 , , , cord-345222-otfnrarh 460 10 as as IN cord-345222-otfnrarh 460 11 over over IN cord-345222-otfnrarh 460 12 300 300 CD cord-345222-otfnrarh 460 13 enzymes enzyme NNS cord-345222-otfnrarh 460 14 require require VBP cord-345222-otfnrarh 460 15 zinc zinc NN cord-345222-otfnrarh 460 16 for for IN cord-345222-otfnrarh 460 17 their -PRON- PRP$ cord-345222-otfnrarh 460 18 activation activation NN cord-345222-otfnrarh 460 19 and and CC cord-345222-otfnrarh 460 20 nearly nearly RB cord-345222-otfnrarh 460 21 2000 2000 CD cord-345222-otfnrarh 460 22 transcription transcription NN cord-345222-otfnrarh 460 23 factors factor NNS cord-345222-otfnrarh 460 24 require require VBP cord-345222-otfnrarh 460 25 zinc zinc NN cord-345222-otfnrarh 460 26 for for IN cord-345222-otfnrarh 460 27 gene gene NN cord-345222-otfnrarh 460 28 expression expression NN cord-345222-otfnrarh 460 29 . . . cord-345222-otfnrarh 461 1 Zinc zinc NN cord-345222-otfnrarh 461 2 is be VBZ cord-345222-otfnrarh 461 3 essential essential JJ cord-345222-otfnrarh 461 4 for for IN cord-345222-otfnrarh 461 5 epithelial epithelial JJ cord-345222-otfnrarh 461 6 barrier barrier NN cord-345222-otfnrarh 461 7 integrity integrity NN cord-345222-otfnrarh 461 8 , , , cord-345222-otfnrarh 461 9 tissue tissue NN cord-345222-otfnrarh 461 10 repair repair NN cord-345222-otfnrarh 461 11 , , , cord-345222-otfnrarh 461 12 cell cell NN cord-345222-otfnrarh 461 13 - - HYPH cord-345222-otfnrarh 461 14 mediated mediate VBN cord-345222-otfnrarh 461 15 immunity immunity NN cord-345222-otfnrarh 461 16 , , , cord-345222-otfnrarh 461 17 and and CC cord-345222-otfnrarh 461 18 immune immune JJ cord-345222-otfnrarh 461 19 function function NN cord-345222-otfnrarh 461 20 . . . cord-345222-otfnrarh 462 1 Zinc zinc NN cord-345222-otfnrarh 462 2 as as IN cord-345222-otfnrarh 462 3 an an DT cord-345222-otfnrarh 462 4 antioxidant antioxidant JJ cord-345222-otfnrarh 462 5 and and CC cord-345222-otfnrarh 462 6 antiinflammatory antiinflammatory JJ cord-345222-otfnrarh 462 7 agent agent NN cord-345222-otfnrarh 462 8 is be VBZ cord-345222-otfnrarh 462 9 effective effective JJ cord-345222-otfnrarh 462 10 in in IN cord-345222-otfnrarh 462 11 gastrointestinal gastrointestinal JJ cord-345222-otfnrarh 462 12 structure structure NN cord-345222-otfnrarh 462 13 and and CC cord-345222-otfnrarh 462 14 function function NN cord-345222-otfnrarh 462 15 . . . cord-345222-otfnrarh 463 1 137 137 CD cord-345222-otfnrarh 463 2 Diarrhea diarrhea NN cord-345222-otfnrarh 463 3 is be VBZ cord-345222-otfnrarh 463 4 associated associate VBN cord-345222-otfnrarh 463 5 with with IN cord-345222-otfnrarh 463 6 significant significant JJ cord-345222-otfnrarh 463 7 zinc zinc NN cord-345222-otfnrarh 463 8 loss loss NN cord-345222-otfnrarh 463 9 , , , cord-345222-otfnrarh 463 10 and and CC cord-345222-otfnrarh 463 11 the the DT cord-345222-otfnrarh 463 12 use use NN cord-345222-otfnrarh 463 13 of of IN cord-345222-otfnrarh 463 14 zinc zinc NN cord-345222-otfnrarh 463 15 supplements supplement NNS cord-345222-otfnrarh 463 16 can can MD cord-345222-otfnrarh 463 17 reduce reduce VB cord-345222-otfnrarh 463 18 the the DT cord-345222-otfnrarh 463 19 duration duration NN cord-345222-otfnrarh 463 20 and and CC cord-345222-otfnrarh 463 21 severity severity NN cord-345222-otfnrarh 463 22 of of IN cord-345222-otfnrarh 463 23 diarrhea diarrhea NN cord-345222-otfnrarh 463 24 in in IN cord-345222-otfnrarh 463 25 children child NNS cord-345222-otfnrarh 463 26 . . . cord-345222-otfnrarh 464 1 In in IN cord-345222-otfnrarh 464 2 areas area NNS cord-345222-otfnrarh 464 3 where where WRB cord-345222-otfnrarh 464 4 the the DT cord-345222-otfnrarh 464 5 prevalence prevalence NN cord-345222-otfnrarh 464 6 of of IN cord-345222-otfnrarh 464 7 zinc zinc NN cord-345222-otfnrarh 464 8 deficiency deficiency NN cord-345222-otfnrarh 464 9 or or CC cord-345222-otfnrarh 464 10 the the DT cord-345222-otfnrarh 464 11 prevalence prevalence NN cord-345222-otfnrarh 464 12 of of IN cord-345222-otfnrarh 464 13 moderate moderate JJ cord-345222-otfnrarh 464 14 malnutrition malnutrition NN cord-345222-otfnrarh 464 15 is be VBZ cord-345222-otfnrarh 464 16 high high JJ cord-345222-otfnrarh 464 17 , , , cord-345222-otfnrarh 464 18 zinc zinc NN cord-345222-otfnrarh 464 19 may may MD cord-345222-otfnrarh 464 20 be be VB cord-345222-otfnrarh 464 21 of of IN cord-345222-otfnrarh 464 22 benefit benefit NN cord-345222-otfnrarh 464 23 in in IN cord-345222-otfnrarh 464 24 children child NNS cord-345222-otfnrarh 464 25 aged age VBN cord-345222-otfnrarh 464 26 6 6 CD cord-345222-otfnrarh 464 27 months month NNS cord-345222-otfnrarh 464 28 or or CC cord-345222-otfnrarh 464 29 more more JJR cord-345222-otfnrarh 464 30 . . . cord-345222-otfnrarh 465 1 The the DT cord-345222-otfnrarh 465 2 current current JJ cord-345222-otfnrarh 465 3 evidence evidence NN cord-345222-otfnrarh 465 4 does do VBZ cord-345222-otfnrarh 465 5 not not RB cord-345222-otfnrarh 465 6 support support VB cord-345222-otfnrarh 465 7 the the DT cord-345222-otfnrarh 465 8 use use NN cord-345222-otfnrarh 465 9 of of IN cord-345222-otfnrarh 465 10 zinc zinc NN cord-345222-otfnrarh 465 11 supplementation supplementation NN cord-345222-otfnrarh 465 12 in in IN cord-345222-otfnrarh 465 13 children child NNS cord-345222-otfnrarh 465 14 below below IN cord-345222-otfnrarh 465 15 6 6 CD cord-345222-otfnrarh 465 16 months month NNS cord-345222-otfnrarh 465 17 of of IN cord-345222-otfnrarh 465 18 age age NN cord-345222-otfnrarh 465 19 . . . cord-345222-otfnrarh 466 1 138 138 CD cord-345222-otfnrarh 467 1 The the DT cord-345222-otfnrarh 467 2 WHO who WP cord-345222-otfnrarh 467 3 has have VBZ cord-345222-otfnrarh 467 4 recommended recommend VBN cord-345222-otfnrarh 467 5 zinc zinc NN cord-345222-otfnrarh 467 6 supplementation supplementation NN cord-345222-otfnrarh 467 7 in in IN cord-345222-otfnrarh 467 8 children child NNS cord-345222-otfnrarh 467 9 with with IN cord-345222-otfnrarh 467 10 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 467 11 . . . cord-345222-otfnrarh 468 1 Supplements supplement NNS cord-345222-otfnrarh 468 2 should should MD cord-345222-otfnrarh 468 3 be be VB cord-345222-otfnrarh 468 4 started start VBN cord-345222-otfnrarh 468 5 at at IN cord-345222-otfnrarh 468 6 the the DT cord-345222-otfnrarh 468 7 beginning beginning NN cord-345222-otfnrarh 468 8 of of IN cord-345222-otfnrarh 468 9 the the DT cord-345222-otfnrarh 468 10 symptoms symptom NNS cord-345222-otfnrarh 468 11 . . . cord-345222-otfnrarh 469 1 Recommended recommend VBN cord-345222-otfnrarh 469 2 doses dose NNS cord-345222-otfnrarh 469 3 and and CC cord-345222-otfnrarh 469 4 duration duration NN cord-345222-otfnrarh 469 5 : : : cord-345222-otfnrarh 470 1 • • NNP cord-345222-otfnrarh 470 2 for for IN cord-345222-otfnrarh 470 3 children child NNS cord-345222-otfnrarh 470 4 less less JJR cord-345222-otfnrarh 470 5 than than IN cord-345222-otfnrarh 470 6 6 6 CD cord-345222-otfnrarh 470 7 months month NNS cord-345222-otfnrarh 470 8 of of IN cord-345222-otfnrarh 470 9 age age NN cord-345222-otfnrarh 470 10 , , , cord-345222-otfnrarh 470 11 10 10 CD cord-345222-otfnrarh 470 12 mg mg NNP cord-345222-otfnrarh 470 13 daily daily RB cord-345222-otfnrarh 470 14 for for IN cord-345222-otfnrarh 470 15 10 10 CD cord-345222-otfnrarh 470 16 days day NNS cord-345222-otfnrarh 471 1 • • NNP cord-345222-otfnrarh 471 2 for for IN cord-345222-otfnrarh 471 3 children child NNS cord-345222-otfnrarh 471 4 from from IN cord-345222-otfnrarh 471 5 6 6 CD cord-345222-otfnrarh 471 6 months month NNS cord-345222-otfnrarh 471 7 to to IN cord-345222-otfnrarh 471 8 5 5 CD cord-345222-otfnrarh 471 9 years year NNS cord-345222-otfnrarh 471 10 of of IN cord-345222-otfnrarh 471 11 age age NN cord-345222-otfnrarh 471 12 , , , cord-345222-otfnrarh 471 13 20 20 CD cord-345222-otfnrarh 471 14 mg mg NNP cord-345222-otfnrarh 471 15 daily daily RB cord-345222-otfnrarh 471 16 for for IN cord-345222-otfnrarh 471 17 10 10 CD cord-345222-otfnrarh 471 18 days day NNS cord-345222-otfnrarh 471 19 . . . cord-345222-otfnrarh 472 1 This this DT cord-345222-otfnrarh 472 2 therapy therapy NN cord-345222-otfnrarh 472 3 decreases decrease VBZ cord-345222-otfnrarh 472 4 the the DT cord-345222-otfnrarh 472 5 severity severity NN cord-345222-otfnrarh 472 6 and and CC cord-345222-otfnrarh 472 7 reduces reduce VBZ cord-345222-otfnrarh 472 8 the the DT cord-345222-otfnrarh 472 9 number number NN cord-345222-otfnrarh 472 10 of of IN cord-345222-otfnrarh 472 11 episodes episode NNS cord-345222-otfnrarh 472 12 of of IN cord-345222-otfnrarh 472 13 diarrhea diarrhea NN cord-345222-otfnrarh 472 14 occurring occur VBG cord-345222-otfnrarh 472 15 within within IN cord-345222-otfnrarh 472 16 2 2 CD cord-345222-otfnrarh 472 17 - - SYM cord-345222-otfnrarh 472 18 3 3 CD cord-345222-otfnrarh 472 19 months month NNS cord-345222-otfnrarh 472 20 following follow VBG cord-345222-otfnrarh 472 21 the the DT cord-345222-otfnrarh 472 22 intake intake NN cord-345222-otfnrarh 472 23 of of IN cord-345222-otfnrarh 472 24 zinc zinc NN cord-345222-otfnrarh 472 25 . . . cord-345222-otfnrarh 473 1 139 139 CD cord-345222-otfnrarh 473 2 _SP cord-345222-otfnrarh 474 1 The the DT cord-345222-otfnrarh 474 2 physiological physiological JJ cord-345222-otfnrarh 474 3 composition composition NN cord-345222-otfnrarh 474 4 of of IN cord-345222-otfnrarh 474 5 intestinal intestinal JJ cord-345222-otfnrarh 474 6 microflora microflora NN cord-345222-otfnrarh 474 7 is be VBZ cord-345222-otfnrarh 474 8 essential essential JJ cord-345222-otfnrarh 474 9 to to TO cord-345222-otfnrarh 474 10 maintain maintain VB cord-345222-otfnrarh 474 11 an an DT cord-345222-otfnrarh 474 12 appropriate appropriate JJ cord-345222-otfnrarh 474 13 balance balance NN cord-345222-otfnrarh 474 14 of of IN cord-345222-otfnrarh 474 15 microbiota microbiota NN cord-345222-otfnrarh 474 16 and and CC cord-345222-otfnrarh 474 17 the the DT cord-345222-otfnrarh 474 18 intestinal intestinal JJ cord-345222-otfnrarh 474 19 barrier barrier NN cord-345222-otfnrarh 474 20 . . . cord-345222-otfnrarh 475 1 Probiotics probiotic NNS cord-345222-otfnrarh 475 2 , , , cord-345222-otfnrarh 475 3 also also RB cord-345222-otfnrarh 475 4 defined define VBN cord-345222-otfnrarh 475 5 as as IN cord-345222-otfnrarh 475 6 food food NN cord-345222-otfnrarh 475 7 supplements supplement NNS cord-345222-otfnrarh 475 8 , , , cord-345222-otfnrarh 475 9 improve improve VB cord-345222-otfnrarh 475 10 the the DT cord-345222-otfnrarh 475 11 intestinal intestinal JJ cord-345222-otfnrarh 475 12 microbial microbial JJ cord-345222-otfnrarh 475 13 balance balance NN cord-345222-otfnrarh 475 14 of of IN cord-345222-otfnrarh 475 15 the the DT cord-345222-otfnrarh 475 16 host host NN cord-345222-otfnrarh 475 17 , , , cord-345222-otfnrarh 475 18 have have VBP cord-345222-otfnrarh 475 19 beneficial beneficial JJ cord-345222-otfnrarh 475 20 effects effect NNS cord-345222-otfnrarh 475 21 on on IN cord-345222-otfnrarh 475 22 health health NN cord-345222-otfnrarh 475 23 , , , cord-345222-otfnrarh 475 24 prevent prevent JJ cord-345222-otfnrarh 475 25 outbreaks outbreak NNS cord-345222-otfnrarh 475 26 of of IN cord-345222-otfnrarh 475 27 community community NN cord-345222-otfnrarh 475 28 - - HYPH cord-345222-otfnrarh 475 29 acquired acquire VBN cord-345222-otfnrarh 475 30 diarrhea diarrhea NN cord-345222-otfnrarh 475 31 , , , cord-345222-otfnrarh 475 32 reduce reduce VB cord-345222-otfnrarh 475 33 colonization colonization NN cord-345222-otfnrarh 475 34 of of IN cord-345222-otfnrarh 475 35 infants infant NNS cord-345222-otfnrarh 475 36 with with IN cord-345222-otfnrarh 475 37 pathogenic pathogenic JJ cord-345222-otfnrarh 475 38 microorganisms microorganism NNS cord-345222-otfnrarh 475 39 , , , cord-345222-otfnrarh 475 40 and and CC cord-345222-otfnrarh 475 41 reduce reduce VB cord-345222-otfnrarh 475 42 the the DT cord-345222-otfnrarh 475 43 duration duration NN cord-345222-otfnrarh 475 44 and and CC cord-345222-otfnrarh 475 45 severity severity NN cord-345222-otfnrarh 475 46 of of IN cord-345222-otfnrarh 475 47 diarrheal diarrheal JJ cord-345222-otfnrarh 475 48 infections infection NNS cord-345222-otfnrarh 475 49 , , , cord-345222-otfnrarh 475 50 balancing balance VBG cord-345222-otfnrarh 475 51 the the DT cord-345222-otfnrarh 475 52 intestinal intestinal JJ cord-345222-otfnrarh 475 53 ecosystem ecosystem NN cord-345222-otfnrarh 475 54 . . . cord-345222-otfnrarh 476 1 In in IN cord-345222-otfnrarh 476 2 large large JJ cord-345222-otfnrarh 476 3 clinical clinical JJ cord-345222-otfnrarh 476 4 trials trial NNS cord-345222-otfnrarh 476 5 , , , cord-345222-otfnrarh 476 6 Lactobacillus lactobacillus NN cord-345222-otfnrarh 476 7 reuteri reuteri NN cord-345222-otfnrarh 476 8 , , , cord-345222-otfnrarh 476 9 LGG LGG NNP cord-345222-otfnrarh 476 10 , , , cord-345222-otfnrarh 476 11 and and CC cord-345222-otfnrarh 476 12 Saccharomyces Saccharomyces NNP cord-345222-otfnrarh 476 13 boulardii boulardii WDT cord-345222-otfnrarh 476 14 have have VBP cord-345222-otfnrarh 476 15 shown show VBN cord-345222-otfnrarh 476 16 the the DT cord-345222-otfnrarh 476 17 best good JJS cord-345222-otfnrarh 476 18 therapeutic therapeutic JJ cord-345222-otfnrarh 476 19 effects effect NNS cord-345222-otfnrarh 476 20 ( ( -LRB- cord-345222-otfnrarh 476 21 reducing reduce VBG cord-345222-otfnrarh 476 22 mean mean JJ cord-345222-otfnrarh 476 23 duration duration NN cord-345222-otfnrarh 476 24 and and CC cord-345222-otfnrarh 476 25 frequency frequency NN cord-345222-otfnrarh 476 26 of of IN cord-345222-otfnrarh 476 27 watery watery JJ cord-345222-otfnrarh 476 28 diarrhea diarrhea NN cord-345222-otfnrarh 476 29 and and CC cord-345222-otfnrarh 476 30 number number NN cord-345222-otfnrarh 476 31 of of IN cord-345222-otfnrarh 476 32 watery watery JJ cord-345222-otfnrarh 476 33 stools stool NNS cord-345222-otfnrarh 476 34 per per IN cord-345222-otfnrarh 476 35 day day NN cord-345222-otfnrarh 476 36 , , , cord-345222-otfnrarh 476 37 and and CC cord-345222-otfnrarh 476 38 improving improve VBG cord-345222-otfnrarh 476 39 stool stool NN cord-345222-otfnrarh 476 40 's 's POS cord-345222-otfnrarh 476 41 consistency consistency NN cord-345222-otfnrarh 476 42 ) ) -RRB- cord-345222-otfnrarh 476 43 . . . cord-345222-otfnrarh 477 1 [ [ -LRB- cord-345222-otfnrarh 477 2 140 140 CD cord-345222-otfnrarh 477 3 ] ] -RRB- cord-345222-otfnrarh 477 4 [ [ -LRB- cord-345222-otfnrarh 477 5 141 141 CD cord-345222-otfnrarh 477 6 ] ] -RRB- cord-345222-otfnrarh 477 7 [ [ -LRB- cord-345222-otfnrarh 477 8 142 142 CD cord-345222-otfnrarh 477 9 ] ] -RRB- cord-345222-otfnrarh 478 1 Particularly particularly RB cord-345222-otfnrarh 478 2 , , , cord-345222-otfnrarh 478 3 a a DT cord-345222-otfnrarh 478 4 recent recent JJ cord-345222-otfnrarh 478 5 randomized randomized JJ cord-345222-otfnrarh 478 6 double double JJ cord-345222-otfnrarh 478 7 blind blind JJ cord-345222-otfnrarh 478 8 study study NN cord-345222-otfnrarh 478 9 carried carry VBD cord-345222-otfnrarh 478 10 out out RP cord-345222-otfnrarh 478 11 in in IN cord-345222-otfnrarh 478 12 three three CD cord-345222-otfnrarh 478 13 Italian italian JJ cord-345222-otfnrarh 478 14 pediatric pediatric JJ cord-345222-otfnrarh 478 15 centers center NNS cord-345222-otfnrarh 478 16 showed show VBD cord-345222-otfnrarh 478 17 that that IN cord-345222-otfnrarh 478 18 L. L. NNP cord-345222-otfnrarh 478 19 reuteri reuteri NN cord-345222-otfnrarh 478 20 DSM DSM NNP cord-345222-otfnrarh 478 21 17938 17938 CD cord-345222-otfnrarh 478 22 , , , cord-345222-otfnrarh 478 23 taken take VBN cord-345222-otfnrarh 478 24 together together RB cord-345222-otfnrarh 478 25 with with IN cord-345222-otfnrarh 478 26 a a DT cord-345222-otfnrarh 478 27 standard standard JJ cord-345222-otfnrarh 478 28 ORS ORS NNP cord-345222-otfnrarh 478 29 , , , cord-345222-otfnrarh 478 30 significantly significantly RB cord-345222-otfnrarh 478 31 reduced reduce VBD cord-345222-otfnrarh 478 32 the the DT cord-345222-otfnrarh 478 33 duration duration NN cord-345222-otfnrarh 478 34 of of IN cord-345222-otfnrarh 478 35 watery watery JJ cord-345222-otfnrarh 478 36 diarrhea diarrhea NN cord-345222-otfnrarh 478 37 compared compare VBN cord-345222-otfnrarh 478 38 with with IN cord-345222-otfnrarh 478 39 placebo placebo NN cord-345222-otfnrarh 478 40 ( ( -LRB- cord-345222-otfnrarh 478 41 2.1 2.1 CD cord-345222-otfnrarh 478 42 ± ± CD cord-345222-otfnrarh 478 43 1.7 1.7 CD cord-345222-otfnrarh 478 44 days day NNS cord-345222-otfnrarh 478 45 vs vs IN cord-345222-otfnrarh 478 46 3.3 3.3 CD cord-345222-otfnrarh 478 47 ± ± CD cord-345222-otfnrarh 478 48 2.1 2.1 CD cord-345222-otfnrarh 478 49 days day NNS cord-345222-otfnrarh 478 50 , , , cord-345222-otfnrarh 478 51 P p NN cord-345222-otfnrarh 478 52 , , , cord-345222-otfnrarh 478 53 0.03 0.03 CD cord-345222-otfnrarh 478 54 ) ) -RRB- cord-345222-otfnrarh 478 55 . . . cord-345222-otfnrarh 479 1 On on IN cord-345222-otfnrarh 479 2 days day NNS cord-345222-otfnrarh 479 3 two two CD cord-345222-otfnrarh 479 4 and and CC cord-345222-otfnrarh 479 5 three three CD cord-345222-otfnrarh 479 6 of of IN cord-345222-otfnrarh 479 7 treatment treatment NN cord-345222-otfnrarh 479 8 , , , cord-345222-otfnrarh 479 9 watery watery JJ cord-345222-otfnrarh 479 10 diarrhea diarrhea NN cord-345222-otfnrarh 479 11 persisted persist VBD cord-345222-otfnrarh 479 12 in in IN cord-345222-otfnrarh 479 13 82 82 CD cord-345222-otfnrarh 479 14 % % NN cord-345222-otfnrarh 479 15 and and CC cord-345222-otfnrarh 479 16 74 74 CD cord-345222-otfnrarh 479 17 % % NN cord-345222-otfnrarh 479 18 of of IN cord-345222-otfnrarh 479 19 the the DT cord-345222-otfnrarh 479 20 placebo placebo NN cord-345222-otfnrarh 479 21 and and CC cord-345222-otfnrarh 479 22 55 55 CD cord-345222-otfnrarh 479 23 % % NN cord-345222-otfnrarh 479 24 and and CC cord-345222-otfnrarh 479 25 45 45 CD cord-345222-otfnrarh 479 26 % % NN cord-345222-otfnrarh 479 27 of of IN cord-345222-otfnrarh 479 28 the the DT cord-345222-otfnrarh 479 29 L. L. NNP cord-345222-otfnrarh 479 30 reuteri reuteri NN cord-345222-otfnrarh 479 31 recipients recipient NNS cord-345222-otfnrarh 479 32 , , , cord-345222-otfnrarh 479 33 respectively respectively RB cord-345222-otfnrarh 479 34 ( ( -LRB- cord-345222-otfnrarh 479 35 P p NN cord-345222-otfnrarh 479 36 , , , cord-345222-otfnrarh 479 37 0.01 0.01 CD cord-345222-otfnrarh 479 38 , , , cord-345222-otfnrarh 479 39 P p NN cord-345222-otfnrarh 479 40 , , , cord-345222-otfnrarh 479 41 0.03 0.03 CD cord-345222-otfnrarh 479 42 ) ) -RRB- cord-345222-otfnrarh 479 43 . . . cord-345222-otfnrarh 480 1 Moreover moreover RB cord-345222-otfnrarh 480 2 , , , cord-345222-otfnrarh 480 3 children child NNS cord-345222-otfnrarh 480 4 receiving receive VBG cord-345222-otfnrarh 480 5 L. L. NNP cord-345222-otfnrarh 480 6 reuteri reuteri NN cord-345222-otfnrarh 480 7 DSM DSM NNP cord-345222-otfnrarh 480 8 17938 17938 CD cord-345222-otfnrarh 480 9 had have VBD cord-345222-otfnrarh 480 10 a a DT cord-345222-otfnrarh 480 11 significantly significantly RB cord-345222-otfnrarh 480 12 lower low JJR cord-345222-otfnrarh 480 13 relapse relapse NN cord-345222-otfnrarh 480 14 rate rate NN cord-345222-otfnrarh 480 15 of of IN cord-345222-otfnrarh 480 16 diarrhea diarrhea NN cord-345222-otfnrarh 480 17 ( ( -LRB- cord-345222-otfnrarh 480 18 15 15 CD cord-345222-otfnrarh 480 19 % % NN cord-345222-otfnrarh 480 20 vs vs IN cord-345222-otfnrarh 480 21 42 42 CD cord-345222-otfnrarh 480 22 % % NN cord-345222-otfnrarh 480 23 , , , cord-345222-otfnrarh 480 24 P p NN cord-345222-otfnrarh 480 25 , , , cord-345222-otfnrarh 480 26 0.03 0.03 CD cord-345222-otfnrarh 480 27 ) ) -RRB- cord-345222-otfnrarh 480 28 . . . cord-345222-otfnrarh 481 1 143 143 CD cord-345222-otfnrarh 482 1 The the DT cord-345222-otfnrarh 482 2 European European NNP cord-345222-otfnrarh 482 3 Society Society NNP cord-345222-otfnrarh 482 4 of of IN cord-345222-otfnrarh 482 5 Gastroenterology Gastroenterology NNP cord-345222-otfnrarh 482 6 , , , cord-345222-otfnrarh 482 7 Hepatology Hepatology NNP cord-345222-otfnrarh 482 8 , , , cord-345222-otfnrarh 482 9 and and CC cord-345222-otfnrarh 482 10 Nutrition Nutrition NNP cord-345222-otfnrarh 482 11 and and CC cord-345222-otfnrarh 482 12 the the DT cord-345222-otfnrarh 482 13 National National NNP cord-345222-otfnrarh 482 14 Institute Institute NNP cord-345222-otfnrarh 482 15 for for IN cord-345222-otfnrarh 482 16 Health Health NNP cord-345222-otfnrarh 482 17 and and CC cord-345222-otfnrarh 482 18 Clinical Clinical NNP cord-345222-otfnrarh 482 19 Excellence Excellence NNP cord-345222-otfnrarh 482 20 have have VBP cord-345222-otfnrarh 482 21 suggested suggest VBN cord-345222-otfnrarh 482 22 the the DT cord-345222-otfnrarh 482 23 use use NN cord-345222-otfnrarh 482 24 of of IN cord-345222-otfnrarh 482 25 probiotic probiotic JJ cord-345222-otfnrarh 482 26 strains strain NNS cord-345222-otfnrarh 482 27 with with IN cord-345222-otfnrarh 482 28 proven prove VBN cord-345222-otfnrarh 482 29 efficacy efficacy NN cord-345222-otfnrarh 482 30 and and CC cord-345222-otfnrarh 482 31 in in IN cord-345222-otfnrarh 482 32 appropriate appropriate JJ cord-345222-otfnrarh 482 33 doses dose NNS cord-345222-otfnrarh 482 34 for for IN cord-345222-otfnrarh 482 35 the the DT cord-345222-otfnrarh 482 36 management management NN cord-345222-otfnrarh 482 37 of of IN cord-345222-otfnrarh 482 38 children child NNS cord-345222-otfnrarh 482 39 with with IN cord-345222-otfnrarh 482 40 acute acute JJ cord-345222-otfnrarh 482 41 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 482 42 as as IN cord-345222-otfnrarh 482 43 an an DT cord-345222-otfnrarh 482 44 adjunct adjunct NN cord-345222-otfnrarh 482 45 to to IN cord-345222-otfnrarh 482 46 rehydration rehydration NN cord-345222-otfnrarh 482 47 therapy therapy NN cord-345222-otfnrarh 482 48 . . . cord-345222-otfnrarh 483 1 144 144 CD cord-345222-otfnrarh 483 2 , , , cord-345222-otfnrarh 483 3 145 145 CD cord-345222-otfnrarh 483 4 Probiotics probiotic NNS cord-345222-otfnrarh 483 5 and and CC cord-345222-otfnrarh 483 6 symbiotics symbiotic NNS cord-345222-otfnrarh 483 7 are be VBP cord-345222-otfnrarh 483 8 of of IN cord-345222-otfnrarh 483 9 interest interest NN cord-345222-otfnrarh 483 10 as as IN cord-345222-otfnrarh 483 11 they -PRON- PRP cord-345222-otfnrarh 483 12 elicit elicit VBP cord-345222-otfnrarh 483 13 healthpromoting healthpromote VBG cord-345222-otfnrarh 483 14 properties property NNS cord-345222-otfnrarh 483 15 to to IN cord-345222-otfnrarh 483 16 the the DT cord-345222-otfnrarh 483 17 host host NN cord-345222-otfnrarh 483 18 , , , cord-345222-otfnrarh 483 19 release release VB cord-345222-otfnrarh 483 20 various various JJ cord-345222-otfnrarh 483 21 soluble soluble JJ cord-345222-otfnrarh 483 22 low low JJ cord-345222-otfnrarh 483 23 - - HYPH cord-345222-otfnrarh 483 24 molecular molecular JJ cord-345222-otfnrarh 483 25 - - HYPH cord-345222-otfnrarh 483 26 weight weight NN cord-345222-otfnrarh 483 27 molecules molecule NNS cord-345222-otfnrarh 483 28 of of IN cord-345222-otfnrarh 483 29 different different JJ cord-345222-otfnrarh 483 30 nature nature NN cord-345222-otfnrarh 483 31 ( ( -LRB- cord-345222-otfnrarh 483 32 surface surface NN cord-345222-otfnrarh 483 33 and and CC cord-345222-otfnrarh 483 34 exogenous exogenous JJ cord-345222-otfnrarh 483 35 proteins protein NNS cord-345222-otfnrarh 483 36 , , , cord-345222-otfnrarh 483 37 peptides peptide NNS cord-345222-otfnrarh 483 38 , , , cord-345222-otfnrarh 483 39 amines amine NNS cord-345222-otfnrarh 483 40 , , , cord-345222-otfnrarh 483 41 lectins lectin NNS cord-345222-otfnrarh 483 42 , , , cord-345222-otfnrarh 483 43 sirtuines sirtuine NNS cord-345222-otfnrarh 483 44 , , , cord-345222-otfnrarh 483 45 nucleases nuclease NNS cord-345222-otfnrarh 483 46 , , , cord-345222-otfnrarh 483 47 other other JJ cord-345222-otfnrarh 483 48 enzymes enzyme NNS cord-345222-otfnrarh 483 49 , , , cord-345222-otfnrarh 483 50 bacteriocines bacteriocine NNS cord-345222-otfnrarh 483 51 , , , cord-345222-otfnrarh 483 52 fatty fatty JJ cord-345222-otfnrarh 483 53 and and CC cord-345222-otfnrarh 483 54 amino amino JJ cord-345222-otfnrarh 483 55 acids acid NNS cord-345222-otfnrarh 483 56 , , , cord-345222-otfnrarh 483 57 lactones lactone NNS cord-345222-otfnrarh 483 58 , , , cord-345222-otfnrarh 483 59 nitric nitric NN cord-345222-otfnrarh 483 60 oxide oxide NN cord-345222-otfnrarh 483 61 , , , cord-345222-otfnrarh 483 62 etc etc FW cord-345222-otfnrarh 483 63 ) ) -RRB- cord-345222-otfnrarh 483 64 , , , cord-345222-otfnrarh 483 65 are be VBP cord-345222-otfnrarh 483 66 able able JJ cord-345222-otfnrarh 483 67 to to TO cord-345222-otfnrarh 483 68 interact interact VB cord-345222-otfnrarh 483 69 with with IN cord-345222-otfnrarh 483 70 corresponding correspond VBG cord-345222-otfnrarh 483 71 cell cell NN cord-345222-otfnrarh 483 72 receptors receptor NNS cord-345222-otfnrarh 483 73 , , , cord-345222-otfnrarh 483 74 to to TO cord-345222-otfnrarh 483 75 reply reply VB cord-345222-otfnrarh 483 76 quickly quickly RB cord-345222-otfnrarh 483 77 by by IN cord-345222-otfnrarh 483 78 induction induction NN cord-345222-otfnrarh 483 79 of of IN cord-345222-otfnrarh 483 80 special special JJ cord-345222-otfnrarh 483 81 sets set NNS cord-345222-otfnrarh 483 82 of of IN cord-345222-otfnrarh 483 83 genes gene NNS cord-345222-otfnrarh 483 84 , , , cord-345222-otfnrarh 483 85 to to TO cord-345222-otfnrarh 483 86 support support VB cord-345222-otfnrarh 483 87 stability stability NN cord-345222-otfnrarh 483 88 of of IN cord-345222-otfnrarh 483 89 host host NN cord-345222-otfnrarh 483 90 genome genome NN cord-345222-otfnrarh 483 91 and and CC cord-345222-otfnrarh 483 92 microbiome microbiome NN cord-345222-otfnrarh 483 93 , , , cord-345222-otfnrarh 483 94 to to TO cord-345222-otfnrarh 483 95 modulate modulate VB cord-345222-otfnrarh 483 96 epigenomic epigenomic JJ cord-345222-otfnrarh 483 97 regulation regulation NN cord-345222-otfnrarh 483 98 of of IN cord-345222-otfnrarh 483 99 gene gene NN cord-345222-otfnrarh 483 100 phenotypic phenotypic JJ cord-345222-otfnrarh 483 101 expression expression NN cord-345222-otfnrarh 483 102 , , , cord-345222-otfnrarh 483 103 and and CC cord-345222-otfnrarh 483 104 to to TO cord-345222-otfnrarh 483 105 ensure ensure VB cord-345222-otfnrarh 483 106 information information NN cord-345222-otfnrarh 483 107 exchange exchange NN cord-345222-otfnrarh 483 108 in in IN cord-345222-otfnrarh 483 109 numerous numerous JJ cord-345222-otfnrarh 483 110 bacterial bacterial NN cord-345222-otfnrarh 483 111 and and CC cord-345222-otfnrarh 483 112 bacteria bacteria NNS cord-345222-otfnrarh 483 113 - - HYPH cord-345222-otfnrarh 483 114 host host NN cord-345222-otfnrarh 483 115 systems system NNS cord-345222-otfnrarh 483 116 . . . cord-345222-otfnrarh 484 1 All all DT cord-345222-otfnrarh 484 2 this this DT cord-345222-otfnrarh 484 3 plays play VBZ cord-345222-otfnrarh 484 4 an an DT cord-345222-otfnrarh 484 5 important important JJ cord-345222-otfnrarh 484 6 role role NN cord-345222-otfnrarh 484 7 in in IN cord-345222-otfnrarh 484 8 the the DT cord-345222-otfnrarh 484 9 control control NN cord-345222-otfnrarh 484 10 for for IN cord-345222-otfnrarh 484 11 many many JJ cord-345222-otfnrarh 484 12 physiological physiological JJ cord-345222-otfnrarh 484 13 , , , cord-345222-otfnrarh 484 14 biochemical biochemical JJ cord-345222-otfnrarh 484 15 , , , cord-345222-otfnrarh 484 16 and and CC cord-345222-otfnrarh 484 17 genetic genetic JJ cord-345222-otfnrarh 484 18 functions function NNS cord-345222-otfnrarh 484 19 in in IN cord-345222-otfnrarh 484 20 supporting support VBG cord-345222-otfnrarh 484 21 host host NN cord-345222-otfnrarh 484 22 health health NN cord-345222-otfnrarh 484 23 . . . cord-345222-otfnrarh 485 1 Recently recently RB cord-345222-otfnrarh 485 2 , , , cord-345222-otfnrarh 485 3 probiotic probiotic JJ cord-345222-otfnrarh 485 4 L. L. NNP cord-345222-otfnrarh 485 5 reuteri reuteri NN cord-345222-otfnrarh 485 6 strain strain NN cord-345222-otfnrarh 486 1 ATCC ATCC NNP cord-345222-otfnrarh 486 2 PTA PTA NNP cord-345222-otfnrarh 486 3 6475 6475 CD cord-345222-otfnrarh 486 4 demonstrated demonstrate VBD cord-345222-otfnrarh 486 5 the the DT cord-345222-otfnrarh 486 6 ability ability NN cord-345222-otfnrarh 486 7 to to TO cord-345222-otfnrarh 486 8 potently potently RB cord-345222-otfnrarh 486 9 suppress suppress VB cord-345222-otfnrarh 486 10 human human JJ cord-345222-otfnrarh 486 11 tumor tumor NN cord-345222-otfnrarh 486 12 necrosis necrosis NN cord-345222-otfnrarh 486 13 - - HYPH cord-345222-otfnrarh 486 14 factor factor NN cord-345222-otfnrarh 486 15 production production NN cord-345222-otfnrarh 486 16 by by IN cord-345222-otfnrarh 486 17 lipopolysaccharide lipopolysaccharide NN cord-345222-otfnrarh 486 18 - - HYPH cord-345222-otfnrarh 486 19 activated activate VBN cord-345222-otfnrarh 486 20 monocytes monocyte NNS cord-345222-otfnrarh 486 21 and and CC cord-345222-otfnrarh 486 22 primary primary JJ cord-345222-otfnrarh 486 23 monocyte monocyte NN cord-345222-otfnrarh 486 24 - - HYPH cord-345222-otfnrarh 486 25 derived derive VBN cord-345222-otfnrarh 486 26 macrophages macrophage NNS cord-345222-otfnrarh 486 27 from from IN cord-345222-otfnrarh 486 28 children child NNS cord-345222-otfnrarh 486 29 with with IN cord-345222-otfnrarh 486 30 Crohn Crohn NNP cord-345222-otfnrarh 486 31 's 's POS cord-345222-otfnrarh 486 32 disease disease NN cord-345222-otfnrarh 486 33 : : : cord-345222-otfnrarh 486 34 the the DT cord-345222-otfnrarh 486 35 primary primary JJ cord-345222-otfnrarh 486 36 mechanism mechanism NN cord-345222-otfnrarh 486 37 of of IN cord-345222-otfnrarh 486 38 probiotic probiotic NN cord-345222-otfnrarh 486 39 - - HYPH cord-345222-otfnrarh 486 40 mediated mediate VBN cord-345222-otfnrarh 486 41 immunomodulation immunomodulation NN cord-345222-otfnrarh 486 42 is be VBZ cord-345222-otfnrarh 486 43 transcriptional transcriptional JJ cord-345222-otfnrarh 486 44 regulation regulation NN cord-345222-otfnrarh 486 45 . . . cord-345222-otfnrarh 487 1 146 146 CD cord-345222-otfnrarh 488 1 Other other JJ cord-345222-otfnrarh 488 2 researchers researcher NNS cord-345222-otfnrarh 488 3 have have VBP cord-345222-otfnrarh 488 4 confirmed confirm VBN cord-345222-otfnrarh 488 5 these these DT cord-345222-otfnrarh 488 6 results result NNS cord-345222-otfnrarh 488 7 , , , cord-345222-otfnrarh 488 8 and and CC cord-345222-otfnrarh 488 9 it -PRON- PRP cord-345222-otfnrarh 488 10 has have VBZ cord-345222-otfnrarh 488 11 been be VBN cord-345222-otfnrarh 488 12 shown show VBN cord-345222-otfnrarh 488 13 that that IN cord-345222-otfnrarh 488 14 L. L. NNP cord-345222-otfnrarh 488 15 reuteri reuteri NNP cord-345222-otfnrarh 488 16 produce produce VBP cord-345222-otfnrarh 488 17 biologically biologically RB cord-345222-otfnrarh 488 18 active active JJ cord-345222-otfnrarh 488 19 small small JJ cord-345222-otfnrarh 488 20 compounds compound NNS cord-345222-otfnrarh 488 21 , , , cord-345222-otfnrarh 488 22 previously previously RB cord-345222-otfnrarh 488 23 unknown unknown JJ cord-345222-otfnrarh 488 24 , , , cord-345222-otfnrarh 488 25 that that WDT cord-345222-otfnrarh 488 26 can can MD cord-345222-otfnrarh 488 27 modulate modulate VB cord-345222-otfnrarh 488 28 host host NN cord-345222-otfnrarh 488 29 mucosal mucosal JJ cord-345222-otfnrarh 488 30 immunity immunity NN cord-345222-otfnrarh 488 31 . . . cord-345222-otfnrarh 489 1 The the DT cord-345222-otfnrarh 489 2 identification identification NN cord-345222-otfnrarh 489 3 of of IN cord-345222-otfnrarh 489 4 bacterial bacterial JJ cord-345222-otfnrarh 489 5 bioactive bioactive JJ cord-345222-otfnrarh 489 6 metabolites metabolite NNS cord-345222-otfnrarh 489 7 and and CC cord-345222-otfnrarh 489 8 their -PRON- PRP$ cord-345222-otfnrarh 489 9 corresponding corresponding JJ cord-345222-otfnrarh 489 10 mechanisms mechanism NNS cord-345222-otfnrarh 489 11 of of IN cord-345222-otfnrarh 489 12 action action NN cord-345222-otfnrarh 489 13 with with IN cord-345222-otfnrarh 489 14 respect respect NN cord-345222-otfnrarh 489 15 to to IN cord-345222-otfnrarh 489 16 immunomodulation immunomodulation NN cord-345222-otfnrarh 489 17 may may MD cord-345222-otfnrarh 489 18 lead lead VB cord-345222-otfnrarh 489 19 to to IN cord-345222-otfnrarh 489 20 improved improve VBN cord-345222-otfnrarh 489 21 anti anti JJ cord-345222-otfnrarh 489 22 - - JJ cord-345222-otfnrarh 489 23 inflammatory inflammatory JJ cord-345222-otfnrarh 489 24 strategies strategy NNS cord-345222-otfnrarh 489 25 for for IN cord-345222-otfnrarh 489 26 chronic chronic JJ cord-345222-otfnrarh 489 27 immunomediated immunomediate VBN cord-345222-otfnrarh 489 28 diseases disease NNS cord-345222-otfnrarh 489 29 . . . cord-345222-otfnrarh 490 1 147 147 CD cord-345222-otfnrarh 490 2 Antibiotic antibiotic JJ cord-345222-otfnrarh 490 3 therapy therapy NN cord-345222-otfnrarh 490 4 Bacteria Bacteria NNS cord-345222-otfnrarh 491 1 Most Most JJS cord-345222-otfnrarh 491 2 cases case NNS cord-345222-otfnrarh 491 3 of of IN cord-345222-otfnrarh 491 4 AGE age NN cord-345222-otfnrarh 491 5 in in IN cord-345222-otfnrarh 491 6 children child NNS cord-345222-otfnrarh 491 7 are be VBP cord-345222-otfnrarh 491 8 viral viral JJ cord-345222-otfnrarh 491 9 , , , cord-345222-otfnrarh 491 10 self self NN cord-345222-otfnrarh 491 11 - - HYPH cord-345222-otfnrarh 491 12 limited limit VBN cord-345222-otfnrarh 491 13 , , , cord-345222-otfnrarh 491 14 and and CC cord-345222-otfnrarh 491 15 need need VBP cord-345222-otfnrarh 491 16 only only RB cord-345222-otfnrarh 491 17 supportive supportive JJ cord-345222-otfnrarh 491 18 treatment treatment NN cord-345222-otfnrarh 491 19 . . . cord-345222-otfnrarh 492 1 Antibacterial antibacterial JJ cord-345222-otfnrarh 492 2 therapy therapy NN cord-345222-otfnrarh 492 3 serves serve VBZ cord-345222-otfnrarh 492 4 as as IN cord-345222-otfnrarh 492 5 an an DT cord-345222-otfnrarh 492 6 adjunct adjunct NN cord-345222-otfnrarh 492 7 , , , cord-345222-otfnrarh 492 8 to to TO cord-345222-otfnrarh 492 9 shorten shorten VB cord-345222-otfnrarh 492 10 the the DT cord-345222-otfnrarh 492 11 clinical clinical JJ cord-345222-otfnrarh 492 12 course course NN cord-345222-otfnrarh 492 13 , , , cord-345222-otfnrarh 492 14 eradicate eradicate VB cord-345222-otfnrarh 492 15 causative causative JJ cord-345222-otfnrarh 492 16 organisms organism NNS cord-345222-otfnrarh 492 17 , , , cord-345222-otfnrarh 492 18 reduce reduce VB cord-345222-otfnrarh 492 19 transmission transmission NN cord-345222-otfnrarh 492 20 , , , cord-345222-otfnrarh 492 21 and and CC cord-345222-otfnrarh 492 22 prevent prevent VB cord-345222-otfnrarh 492 23 invasive invasive JJ cord-345222-otfnrarh 492 24 comsubmit comsubmit NN cord-345222-otfnrarh 493 1 your -PRON- PRP$ cord-345222-otfnrarh 493 2 manuscript manuscript NN cord-345222-otfnrarh 493 3 | | NNP cord-345222-otfnrarh 493 4 www.dovepress.com www.dovepress.com ADD cord-345222-otfnrarh 494 1 Dovepress Dovepress NNP cord-345222-otfnrarh 494 2 Dovepress Dovepress NNP cord-345222-otfnrarh 494 3 plications plication NNS cord-345222-otfnrarh 494 4 . . . cord-345222-otfnrarh 495 1 Selection selection NN cord-345222-otfnrarh 495 2 of of IN cord-345222-otfnrarh 495 3 antibacterials antibacterial NNS cord-345222-otfnrarh 495 4 to to TO cord-345222-otfnrarh 495 5 use use VB cord-345222-otfnrarh 495 6 in in IN cord-345222-otfnrarh 495 7 acute acute JJ cord-345222-otfnrarh 495 8 bacterial bacterial JJ cord-345222-otfnrarh 495 9 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 495 10 is be VBZ cord-345222-otfnrarh 495 11 based base VBN cord-345222-otfnrarh 495 12 on on IN cord-345222-otfnrarh 495 13 clinical clinical JJ cord-345222-otfnrarh 495 14 diagnosis diagnosis NN cord-345222-otfnrarh 495 15 of of IN cord-345222-otfnrarh 495 16 the the DT cord-345222-otfnrarh 495 17 likely likely JJ cord-345222-otfnrarh 495 18 pathogen pathogen NN cord-345222-otfnrarh 495 19 prior prior RB cord-345222-otfnrarh 495 20 to to IN cord-345222-otfnrarh 495 21 definitive definitive JJ cord-345222-otfnrarh 495 22 laboratory laboratory NN cord-345222-otfnrarh 495 23 results result NNS cord-345222-otfnrarh 495 24 . . . cord-345222-otfnrarh 496 1 Antibacterial antibacterial JJ cord-345222-otfnrarh 496 2 therapy therapy NN cord-345222-otfnrarh 496 3 should should MD cord-345222-otfnrarh 496 4 be be VB cord-345222-otfnrarh 496 5 restricted restrict VBN cord-345222-otfnrarh 496 6 to to IN cord-345222-otfnrarh 496 7 specific specific JJ cord-345222-otfnrarh 496 8 bacterial bacterial JJ cord-345222-otfnrarh 496 9 pathogens pathogen NNS cord-345222-otfnrarh 496 10 and and CC cord-345222-otfnrarh 496 11 disease disease NN cord-345222-otfnrarh 496 12 presentations presentation NNS cord-345222-otfnrarh 496 13 . . . cord-345222-otfnrarh 497 1 In in IN cord-345222-otfnrarh 497 2 general general JJ cord-345222-otfnrarh 497 3 , , , cord-345222-otfnrarh 497 4 infections infection NNS cord-345222-otfnrarh 497 5 with with IN cord-345222-otfnrarh 497 6 Shigella Shigella NNP cord-345222-otfnrarh 497 7 spp spp NNS cord-345222-otfnrarh 497 8 and and CC cord-345222-otfnrarh 497 9 Vibrio Vibrio NNP cord-345222-otfnrarh 497 10 cholera cholera NN cord-345222-otfnrarh 497 11 should should MD cord-345222-otfnrarh 497 12 usually usually RB cord-345222-otfnrarh 497 13 be be VB cord-345222-otfnrarh 497 14 treated treat VBN cord-345222-otfnrarh 497 15 with with IN cord-345222-otfnrarh 497 16 antibacterials antibacterial NNS cord-345222-otfnrarh 497 17 , , , cord-345222-otfnrarh 497 18 while while IN cord-345222-otfnrarh 497 19 antibacterials antibacterial NNS cord-345222-otfnrarh 497 20 are be VBP cord-345222-otfnrarh 497 21 only only RB cord-345222-otfnrarh 497 22 used use VBN cord-345222-otfnrarh 497 23 in in IN cord-345222-otfnrarh 497 24 severe severe JJ cord-345222-otfnrarh 497 25 unresponsive unresponsive JJ cord-345222-otfnrarh 497 26 infections infection NNS cord-345222-otfnrarh 497 27 with with IN cord-345222-otfnrarh 497 28 Salmonella Salmonella NNP cord-345222-otfnrarh 497 29 , , , cord-345222-otfnrarh 497 30 Yersinia Yersinia NNP cord-345222-otfnrarh 497 31 , , , cord-345222-otfnrarh 497 32 Aeromonas Aeromonas NNP cord-345222-otfnrarh 497 33 , , , cord-345222-otfnrarh 497 34 Campylobacter Campylobacter NNP cord-345222-otfnrarh 497 35 , , , cord-345222-otfnrarh 497 36 Plesiomonas Plesiomonas NNP cord-345222-otfnrarh 497 37 spp spp NNS cord-345222-otfnrarh 497 38 , , , cord-345222-otfnrarh 497 39 and and CC cord-345222-otfnrarh 497 40 Clostridium clostridium NN cord-345222-otfnrarh 497 41 difficile difficile NN cord-345222-otfnrarh 497 42 . . . cord-345222-otfnrarh 498 1 Antibacterials antibacterial NNS cord-345222-otfnrarh 498 2 should should MD cord-345222-otfnrarh 498 3 be be VB cord-345222-otfnrarh 498 4 avoided avoid VBN cord-345222-otfnrarh 498 5 in in IN cord-345222-otfnrarh 498 6 EHEC EHEC NNP cord-345222-otfnrarh 498 7 infection infection NN cord-345222-otfnrarh 498 8 . . . cord-345222-otfnrarh 499 1 148 148 CD cord-345222-otfnrarh 500 1 There there EX cord-345222-otfnrarh 500 2 is be VBZ cord-345222-otfnrarh 500 3 no no DT cord-345222-otfnrarh 500 4 evidence evidence NN cord-345222-otfnrarh 500 5 of of IN cord-345222-otfnrarh 500 6 benefit benefit NN cord-345222-otfnrarh 500 7 for for IN cord-345222-otfnrarh 500 8 antibiotics antibiotic NNS cord-345222-otfnrarh 500 9 in in IN cord-345222-otfnrarh 500 10 nontyphoidal nontyphoidal NNP cord-345222-otfnrarh 500 11 Salmonella Salmonella NNP cord-345222-otfnrarh 500 12 diarrhea diarrhea NN cord-345222-otfnrarh 500 13 in in IN cord-345222-otfnrarh 500 14 otherwise otherwise RB cord-345222-otfnrarh 500 15 healthy healthy JJ cord-345222-otfnrarh 500 16 people people NNS cord-345222-otfnrarh 500 17 . . . cord-345222-otfnrarh 501 1 The the DT cord-345222-otfnrarh 501 2 effects effect NNS cord-345222-otfnrarh 501 3 in in IN cord-345222-otfnrarh 501 4 very very RB cord-345222-otfnrarh 501 5 young young JJ cord-345222-otfnrarh 501 6 people people NNS cord-345222-otfnrarh 501 7 , , , cord-345222-otfnrarh 501 8 very very RB cord-345222-otfnrarh 501 9 old old JJ cord-345222-otfnrarh 501 10 people people NNS cord-345222-otfnrarh 501 11 , , , cord-345222-otfnrarh 501 12 and and CC cord-345222-otfnrarh 501 13 in in IN cord-345222-otfnrarh 501 14 people people NNS cord-345222-otfnrarh 501 15 with with IN cord-345222-otfnrarh 501 16 severe severe JJ cord-345222-otfnrarh 501 17 and and CC cord-345222-otfnrarh 501 18 extraintestinal extraintestinal JJ cord-345222-otfnrarh 501 19 disease disease NN cord-345222-otfnrarh 501 20 are be VBP cord-345222-otfnrarh 501 21 not not RB cord-345222-otfnrarh 501 22 always always RB cord-345222-otfnrarh 501 23 so so RB cord-345222-otfnrarh 501 24 clear clear JJ cord-345222-otfnrarh 501 25 , , , cord-345222-otfnrarh 501 26 and and CC cord-345222-otfnrarh 501 27 a a DT cord-345222-otfnrarh 501 28 slightly slightly RB cord-345222-otfnrarh 501 29 higher high JJR cord-345222-otfnrarh 501 30 number number NN cord-345222-otfnrarh 501 31 of of IN cord-345222-otfnrarh 501 32 adverse adverse JJ cord-345222-otfnrarh 501 33 events event NNS cord-345222-otfnrarh 501 34 are be VBP cord-345222-otfnrarh 501 35 noted note VBN cord-345222-otfnrarh 501 36 in in IN cord-345222-otfnrarh 501 37 people people NNS cord-345222-otfnrarh 501 38 who who WP cord-345222-otfnrarh 501 39 receive receive VBP cord-345222-otfnrarh 501 40 antibiotic antibiotic JJ cord-345222-otfnrarh 501 41 treatment treatment NN cord-345222-otfnrarh 501 42 for for IN cord-345222-otfnrarh 501 43 nontyphoidal nontyphoidal NNP cord-345222-otfnrarh 501 44 Salmonella Salmonella NNP cord-345222-otfnrarh 501 45 diarrhea diarrhea NN cord-345222-otfnrarh 501 46 . . . cord-345222-otfnrarh 502 1 149 149 CD cord-345222-otfnrarh 503 1 However however RB cord-345222-otfnrarh 503 2 , , , cord-345222-otfnrarh 503 3 empiric empiric JJ cord-345222-otfnrarh 503 4 therapy therapy NN cord-345222-otfnrarh 503 5 may may MD cord-345222-otfnrarh 503 6 be be VB cord-345222-otfnrarh 503 7 appropriate appropriate JJ cord-345222-otfnrarh 503 8 in in IN cord-345222-otfnrarh 503 9 the the DT cord-345222-otfnrarh 503 10 presence presence NN cord-345222-otfnrarh 503 11 of of IN cord-345222-otfnrarh 503 12 a a DT cord-345222-otfnrarh 503 13 severe severe JJ cord-345222-otfnrarh 503 14 illness illness NN cord-345222-otfnrarh 503 15 with with IN cord-345222-otfnrarh 503 16 bloody bloody JJ cord-345222-otfnrarh 503 17 diarrhea diarrhea NN cord-345222-otfnrarh 503 18 and and CC cord-345222-otfnrarh 503 19 stool stool NN cord-345222-otfnrarh 503 20 leucocytes leucocyte NNS cord-345222-otfnrarh 503 21 , , , cord-345222-otfnrarh 503 22 and and CC cord-345222-otfnrarh 503 23 particularly particularly RB cord-345222-otfnrarh 503 24 in in IN cord-345222-otfnrarh 503 25 patients patient NNS cord-345222-otfnrarh 503 26 with with IN cord-345222-otfnrarh 503 27 risk risk NN cord-345222-otfnrarh 503 28 factors factor NNS cord-345222-otfnrarh 503 29 ( ( -LRB- cord-345222-otfnrarh 503 30 ill ill RB cord-345222-otfnrarh 503 31 - - HYPH cord-345222-otfnrarh 503 32 fed feed VBN cord-345222-otfnrarh 503 33 or or CC cord-345222-otfnrarh 503 34 debilitated debilitated JJ cord-345222-otfnrarh 503 35 patients patient NNS cord-345222-otfnrarh 503 36 ) ) -RRB- cord-345222-otfnrarh 503 37 , , , cord-345222-otfnrarh 503 38 the the DT cord-345222-otfnrarh 503 39 use use NN cord-345222-otfnrarh 503 40 of of IN cord-345222-otfnrarh 503 41 systemic systemic JJ cord-345222-otfnrarh 503 42 antibiotics antibiotic NNS cord-345222-otfnrarh 503 43 has have VBZ cord-345222-otfnrarh 503 44 been be VBN cord-345222-otfnrarh 503 45 recommended recommend VBN cord-345222-otfnrarh 503 46 ( ( -LRB- cord-345222-otfnrarh 503 47 Table table NN cord-345222-otfnrarh 503 48 8) 8) NN cord-345222-otfnrarh 503 49 . . . cord-345222-otfnrarh 504 1 148 148 CD cord-345222-otfnrarh 504 2 , , , cord-345222-otfnrarh 504 3 150 150 CD cord-345222-otfnrarh 505 1 The the DT cord-345222-otfnrarh 505 2 benefits benefit NNS cord-345222-otfnrarh 505 3 and and CC cord-345222-otfnrarh 505 4 risks risk NNS cord-345222-otfnrarh 505 5 of of IN cord-345222-otfnrarh 505 6 adverse adverse JJ cord-345222-otfnrarh 505 7 drug drug NN cord-345222-otfnrarh 505 8 reactions reaction NNS cord-345222-otfnrarh 505 9 should should MD cord-345222-otfnrarh 505 10 be be VB cord-345222-otfnrarh 505 11 weighed weigh VBN cord-345222-otfnrarh 505 12 before before IN cord-345222-otfnrarh 505 13 prescribing prescribe VBG cord-345222-otfnrarh 505 14 antibacterials antibacterial NNS cord-345222-otfnrarh 505 15 . . . cord-345222-otfnrarh 506 1 Moreover moreover RB cord-345222-otfnrarh 506 2 , , , cord-345222-otfnrarh 506 3 a a DT cord-345222-otfnrarh 506 4 major major JJ cord-345222-otfnrarh 506 5 concern concern NN cord-345222-otfnrarh 506 6 is be VBZ cord-345222-otfnrarh 506 7 the the DT cord-345222-otfnrarh 506 8 emergence emergence NN cord-345222-otfnrarh 506 9 of of IN cord-345222-otfnrarh 506 10 antibacterial antibacterial JJ cord-345222-otfnrarh 506 11 - - HYPH cord-345222-otfnrarh 506 12 resistant resistant JJ cord-345222-otfnrarh 506 13 strains strain NNS cord-345222-otfnrarh 506 14 due due IN cord-345222-otfnrarh 506 15 to to IN cord-345222-otfnrarh 506 16 the the DT cord-345222-otfnrarh 506 17 widespread widespread JJ cord-345222-otfnrarh 506 18 use use NN cord-345222-otfnrarh 506 19 of of IN cord-345222-otfnrarh 506 20 antibacterial antibacterial JJ cord-345222-otfnrarh 506 21 agents agent NNS cord-345222-otfnrarh 506 22 . . . cord-345222-otfnrarh 507 1 Aeromonas Aeromonas NNP cord-345222-otfnrarh 507 2 spp spp NNS cord-345222-otfnrarh 507 3 produce produce VBP cord-345222-otfnrarh 507 4 a a DT cord-345222-otfnrarh 507 5 β β NN cord-345222-otfnrarh 507 6 - - HYPH cord-345222-otfnrarh 507 7 lactamase lactamase NN cord-345222-otfnrarh 507 8 that that WDT cord-345222-otfnrarh 507 9 induces induce VBZ cord-345222-otfnrarh 507 10 resistance resistance NN cord-345222-otfnrarh 507 11 to to IN cord-345222-otfnrarh 507 12 penicillin penicillin NN cord-345222-otfnrarh 507 13 and and CC cord-345222-otfnrarh 507 14 first first JJ cord-345222-otfnrarh 507 15 - - HYPH cord-345222-otfnrarh 507 16 generation generation NN cord-345222-otfnrarh 507 17 cephalosporins cephalosporin NNS cord-345222-otfnrarh 507 18 . . . cord-345222-otfnrarh 508 1 In in IN cord-345222-otfnrarh 508 2 fact fact NN cord-345222-otfnrarh 508 3 , , , cord-345222-otfnrarh 508 4 several several JJ cord-345222-otfnrarh 508 5 studies study NNS cord-345222-otfnrarh 508 6 have have VBP cord-345222-otfnrarh 508 7 demonstrated demonstrate VBN cord-345222-otfnrarh 508 8 a a DT cord-345222-otfnrarh 508 9 relatively relatively RB cord-345222-otfnrarh 508 10 high high JJ cord-345222-otfnrarh 508 11 resistance resistance NN cord-345222-otfnrarh 508 12 rates rate NNS cord-345222-otfnrarh 508 13 for for IN cord-345222-otfnrarh 508 14 cephalothin cephalothin NNP cord-345222-otfnrarh 508 15 and and CC cord-345222-otfnrarh 508 16 for for IN cord-345222-otfnrarh 508 17 trimethoprimsulfamethoxazole trimethoprimsulfamethoxazole NNP cord-345222-otfnrarh 508 18 ; ; : cord-345222-otfnrarh 508 19 low low JJ cord-345222-otfnrarh 508 20 rates rate NNS cord-345222-otfnrarh 508 21 of of IN cord-345222-otfnrarh 508 22 resistance resistance NN cord-345222-otfnrarh 508 23 has have VBZ cord-345222-otfnrarh 508 24 been be VBN cord-345222-otfnrarh 508 25 found find VBN cord-345222-otfnrarh 508 26 to to IN cord-345222-otfnrarh 508 27 third third JJ cord-345222-otfnrarh 508 28 generation generation NN cord-345222-otfnrarh 508 29 cephalosporin cephalosporin NN cord-345222-otfnrarh 508 30 ( ( -LRB- cord-345222-otfnrarh 508 31 cefotaxime cefotaxime NNP cord-345222-otfnrarh 508 32 ) ) -RRB- cord-345222-otfnrarh 508 33 , , , cord-345222-otfnrarh 508 34 to to IN cord-345222-otfnrarh 508 35 ciprofloxacin ciprofloxacin NN cord-345222-otfnrarh 508 36 and and CC cord-345222-otfnrarh 508 37 to to IN cord-345222-otfnrarh 508 38 chloramphenicol chloramphenicol NNP cord-345222-otfnrarh 508 39 . . . cord-345222-otfnrarh 509 1 With with IN cord-345222-otfnrarh 509 2 high high JJ cord-345222-otfnrarh 509 3 levels level NNS cord-345222-otfnrarh 509 4 of of IN cord-345222-otfnrarh 509 5 resistance resistance NN cord-345222-otfnrarh 509 6 to to IN cord-345222-otfnrarh 509 7 many many JJ cord-345222-otfnrarh 509 8 antibiotics antibiotic NNS cord-345222-otfnrarh 509 9 , , , cord-345222-otfnrarh 509 10 resistance resistance NN cord-345222-otfnrarh 509 11 of of IN cord-345222-otfnrarh 509 12 A. a. NN cord-345222-otfnrarh 509 13 hydrophila hydrophila NN cord-345222-otfnrarh 509 14 to to IN cord-345222-otfnrarh 509 15 ciprofloxacin ciprofloxacin NN cord-345222-otfnrarh 509 16 is be VBZ cord-345222-otfnrarh 509 17 still still RB cord-345222-otfnrarh 509 18 very very RB cord-345222-otfnrarh 509 19 low low JJ cord-345222-otfnrarh 509 20 , , , cord-345222-otfnrarh 509 21 which which WDT cord-345222-otfnrarh 509 22 may may MD cord-345222-otfnrarh 509 23 suggest suggest VB cord-345222-otfnrarh 509 24 that that IN cord-345222-otfnrarh 509 25 ciprofloxacin ciprofloxacin NN cord-345222-otfnrarh 509 26 and and CC cord-345222-otfnrarh 509 27 other other JJ cord-345222-otfnrarh 509 28 quinolone quinolone NNP cord-345222-otfnrarh 509 29 class class NN cord-345222-otfnrarh 509 30 antimicrobials antimicrobial NNS cord-345222-otfnrarh 509 31 may may MD cord-345222-otfnrarh 509 32 be be VB cord-345222-otfnrarh 509 33 considered consider VBN cord-345222-otfnrarh 509 34 as as IN cord-345222-otfnrarh 509 35 potential potential JJ cord-345222-otfnrarh 509 36 drugs drug NNS cord-345222-otfnrarh 509 37 for for IN cord-345222-otfnrarh 509 38 the the DT cord-345222-otfnrarh 509 39 treatment treatment NN cord-345222-otfnrarh 509 40 of of IN cord-345222-otfnrarh 509 41 bacterial bacterial JJ cord-345222-otfnrarh 509 42 diarrhea diarrhea NN cord-345222-otfnrarh 509 43 caused cause VBN cord-345222-otfnrarh 509 44 by by IN cord-345222-otfnrarh 509 45 A. A. NNP cord-345222-otfnrarh 509 46 hydrophila hydrophila NN cord-345222-otfnrarh 509 47 . . . cord-345222-otfnrarh 510 1 21 21 CD cord-345222-otfnrarh 510 2 , , , cord-345222-otfnrarh 510 3 151 151 CD cord-345222-otfnrarh 510 4 , , , cord-345222-otfnrarh 510 5 152 152 CD cord-345222-otfnrarh 511 1 For for IN cord-345222-otfnrarh 511 2 Campylobacter Campylobacter NNP cord-345222-otfnrarh 511 3 jejuni jejuni NNP cord-345222-otfnrarh 511 4 , , , cord-345222-otfnrarh 511 5 antibiotics antibiotic NNS cord-345222-otfnrarh 511 6 are be VBP cord-345222-otfnrarh 511 7 initiated initiate VBN cord-345222-otfnrarh 511 8 in in IN cord-345222-otfnrarh 511 9 cases case NNS cord-345222-otfnrarh 511 10 of of IN cord-345222-otfnrarh 511 11 febrile febrile JJ cord-345222-otfnrarh 511 12 diarrheas diarrhea NNS cord-345222-otfnrarh 511 13 , , , cord-345222-otfnrarh 511 14 especially especially RB cord-345222-otfnrarh 511 15 those those DT cord-345222-otfnrarh 511 16 believed believe VBN cord-345222-otfnrarh 511 17 to to TO cord-345222-otfnrarh 511 18 have have VB cord-345222-otfnrarh 511 19 moderate moderate JJ cord-345222-otfnrarh 511 20 to to IN cord-345222-otfnrarh 511 21 severe severe JJ cord-345222-otfnrarh 511 22 disease disease NN cord-345222-otfnrarh 511 23 . . . cord-345222-otfnrarh 512 1 Considering consider VBG cord-345222-otfnrarh 512 2 the the DT cord-345222-otfnrarh 512 3 increased increase VBN cord-345222-otfnrarh 512 4 incidence incidence NN cord-345222-otfnrarh 512 5 of of IN cord-345222-otfnrarh 512 6 C. C. NNP cord-345222-otfnrarh 512 7 jejuni jejuni NNP cord-345222-otfnrarh 512 8 and and CC cord-345222-otfnrarh 512 9 the the DT cord-345222-otfnrarh 512 10 resistance resistance NN cord-345222-otfnrarh 512 11 of of IN cord-345222-otfnrarh 512 12 the the DT cord-345222-otfnrarh 512 13 great great JJ cord-345222-otfnrarh 512 14 majority majority NN cord-345222-otfnrarh 512 15 of of IN cord-345222-otfnrarh 512 16 isolated isolated JJ cord-345222-otfnrarh 512 17 strains strain NNS cord-345222-otfnrarh 512 18 to to IN cord-345222-otfnrarh 512 19 quinolones quinolones NNP cord-345222-otfnrarh 512 20 , , , cord-345222-otfnrarh 512 21 the the DT cord-345222-otfnrarh 512 22 administration administration NN cord-345222-otfnrarh 512 23 of of IN cord-345222-otfnrarh 512 24 azithromycin azithromycin NNP cord-345222-otfnrarh 512 25 empirically empirically RB cord-345222-otfnrarh 512 26 for for IN cord-345222-otfnrarh 512 27 acute acute JJ cord-345222-otfnrarh 512 28 diarrhea diarrhea NN cord-345222-otfnrarh 512 29 , , , cord-345222-otfnrarh 512 30 when when WRB cord-345222-otfnrarh 512 31 indicated indicate VBN cord-345222-otfnrarh 512 32 , , , cord-345222-otfnrarh 512 33 could could MD cord-345222-otfnrarh 512 34 be be VB cord-345222-otfnrarh 512 35 appropriate appropriate JJ cord-345222-otfnrarh 512 36 . . . cord-345222-otfnrarh 513 1 153 153 CD cord-345222-otfnrarh 513 2 , , , cord-345222-otfnrarh 513 3 154 154 CD cord-345222-otfnrarh 514 1 Moreover moreover RB cord-345222-otfnrarh 514 2 , , , cord-345222-otfnrarh 514 3 erythromycin erythromycin JJ cord-345222-otfnrarh 514 4 treatment treatment NN cord-345222-otfnrarh 514 5 of of IN cord-345222-otfnrarh 514 6 acute acute JJ cord-345222-otfnrarh 514 7 C. C. NNP cord-345222-otfnrarh 514 8 jejuni jejuni NNP cord-345222-otfnrarh 514 9 diarrhea diarrhea NN cord-345222-otfnrarh 514 10 demonstrated demonstrate VBD cord-345222-otfnrarh 514 11 antibacterial antibacterial JJ cord-345222-otfnrarh 514 12 efficacy efficacy NN cord-345222-otfnrarh 514 13 by by IN cord-345222-otfnrarh 514 14 reducing reduce VBG cord-345222-otfnrarh 514 15 the the DT cord-345222-otfnrarh 514 16 mean mean JJ cord-345222-otfnrarh 514 17 number number NN cord-345222-otfnrarh 514 18 of of IN cord-345222-otfnrarh 514 19 days day NNS cord-345222-otfnrarh 514 20 until until IN cord-345222-otfnrarh 514 21 first first JJ cord-345222-otfnrarh 514 22 negative negative JJ cord-345222-otfnrarh 514 23 stool stool NN cord-345222-otfnrarh 514 24 culture culture NN cord-345222-otfnrarh 514 25 . . . cord-345222-otfnrarh 515 1 4 4 LS cord-345222-otfnrarh 516 1 According accord VBG cord-345222-otfnrarh 516 2 to to IN cord-345222-otfnrarh 516 3 recent recent JJ cord-345222-otfnrarh 516 4 studies study NNS cord-345222-otfnrarh 516 5 , , , cord-345222-otfnrarh 516 6 the the DT cord-345222-otfnrarh 516 7 management management NN cord-345222-otfnrarh 516 8 of of IN cord-345222-otfnrarh 516 9 Clostridium Clostridium NNP cord-345222-otfnrarh 516 10 difficile difficile NN cord-345222-otfnrarh 516 11 infections infection NNS cord-345222-otfnrarh 516 12 involves involve VBZ cord-345222-otfnrarh 516 13 three three CD cord-345222-otfnrarh 516 14 basic basic JJ cord-345222-otfnrarh 516 15 principles principle NNS cord-345222-otfnrarh 516 16 : : : cord-345222-otfnrarh 516 17 supportive supportive JJ cord-345222-otfnrarh 516 18 care care NN cord-345222-otfnrarh 516 19 , , , cord-345222-otfnrarh 516 20 discontinuing discontinue VBG cord-345222-otfnrarh 516 21 the the DT cord-345222-otfnrarh 516 22 precipitating precipitate VBG cord-345222-otfnrarh 516 23 antibiotic(s antibiotic(s NNP cord-345222-otfnrarh 516 24 ) ) -RRB- cord-345222-otfnrarh 516 25 , , , cord-345222-otfnrarh 516 26 and and CC cord-345222-otfnrarh 516 27 the the DT cord-345222-otfnrarh 516 28 initiation initiation NN cord-345222-otfnrarh 516 29 of of IN cord-345222-otfnrarh 516 30 effective effective JJ cord-345222-otfnrarh 516 31 anti anti JJ cord-345222-otfnrarh 516 32 - - JJ cord-345222-otfnrarh 516 33 C. c. JJ cord-345222-otfnrarh 516 34 difficile difficile NN cord-345222-otfnrarh 516 35 therapy therapy NN cord-345222-otfnrarh 516 36 . . . cord-345222-otfnrarh 517 1 Discontinuation discontinuation NN cord-345222-otfnrarh 517 2 of of IN cord-345222-otfnrarh 517 3 the the DT cord-345222-otfnrarh 517 4 offending offending JJ cord-345222-otfnrarh 517 5 antibiotic antibiotic NN cord-345222-otfnrarh 517 6 may may MD cord-345222-otfnrarh 517 7 be be VB cord-345222-otfnrarh 517 8 sufficient sufficient JJ cord-345222-otfnrarh 517 9 for for IN cord-345222-otfnrarh 517 10 the the DT cord-345222-otfnrarh 517 11 resolution resolution NN cord-345222-otfnrarh 517 12 of of IN cord-345222-otfnrarh 517 13 mild mild JJ cord-345222-otfnrarh 517 14 symptoms symptom NNS cord-345222-otfnrarh 517 15 and and CC cord-345222-otfnrarh 517 16 facilitates facilitate VBZ cord-345222-otfnrarh 517 17 the the DT cord-345222-otfnrarh 517 18 reconstitution reconstitution NN cord-345222-otfnrarh 517 19 of of IN cord-345222-otfnrarh 517 20 the the DT cord-345222-otfnrarh 517 21 normal normal JJ cord-345222-otfnrarh 517 22 enteric enteric JJ cord-345222-otfnrarh 517 23 flora flora NNS cord-345222-otfnrarh 517 24 . . . cord-345222-otfnrarh 518 1 154 154 CD cord-345222-otfnrarh 519 1 For for IN cord-345222-otfnrarh 519 2 mild mild JJ cord-345222-otfnrarh 519 3 - - HYPH cord-345222-otfnrarh 519 4 moderate moderate JJ cord-345222-otfnrarh 519 5 C. C. NNP cord-345222-otfnrarh 519 6 difficile difficile NN cord-345222-otfnrarh 519 7 infection infection NN cord-345222-otfnrarh 519 8 in in IN cord-345222-otfnrarh 519 9 children child NNS cord-345222-otfnrarh 519 10 , , , cord-345222-otfnrarh 519 11 metronidazole metronidazole NNP cord-345222-otfnrarh 519 12 is be VBZ cord-345222-otfnrarh 519 13 the the DT cord-345222-otfnrarh 519 14 drug drug NN cord-345222-otfnrarh 519 15 of of IN cord-345222-otfnrarh 519 16 choice choice NN cord-345222-otfnrarh 519 17 , , , cord-345222-otfnrarh 519 18 with with IN cord-345222-otfnrarh 519 19 efficacy efficacy NN cord-345222-otfnrarh 519 20 similar similar JJ cord-345222-otfnrarh 519 21 to to IN cord-345222-otfnrarh 519 22 vancomycin vancomycin NNP cord-345222-otfnrarh 519 23 . . . cord-345222-otfnrarh 520 1 For for IN cord-345222-otfnrarh 520 2 severe severe JJ cord-345222-otfnrarh 520 3 infection infection NN cord-345222-otfnrarh 520 4 , , , cord-345222-otfnrarh 520 5 oral oral JJ cord-345222-otfnrarh 520 6 vancomycin vancomycin NN cord-345222-otfnrarh 520 7 with with IN cord-345222-otfnrarh 520 8 intravenous intravenous JJ cord-345222-otfnrarh 520 9 metronidazole metronidazole NNP cord-345222-otfnrarh 520 10 is be VBZ cord-345222-otfnrarh 520 11 recommended recommend VBN cord-345222-otfnrarh 520 12 . . . cord-345222-otfnrarh 521 1 Linezolid Linezolid NNP cord-345222-otfnrarh 521 2 also also RB cord-345222-otfnrarh 521 3 has have VBZ cord-345222-otfnrarh 521 4 a a DT cord-345222-otfnrarh 521 5 potential potential JJ cord-345222-otfnrarh 521 6 impact impact NN cord-345222-otfnrarh 521 7 , , , cord-345222-otfnrarh 521 8 and and CC cord-345222-otfnrarh 521 9 in in IN cord-345222-otfnrarh 521 10 adults adult NNS cord-345222-otfnrarh 521 11 , , , cord-345222-otfnrarh 521 12 recurrence recurrence NN cord-345222-otfnrarh 521 13 is be VBZ cord-345222-otfnrarh 521 14 less less RBR cord-345222-otfnrarh 521 15 frequent frequent JJ cord-345222-otfnrarh 521 16 with with IN cord-345222-otfnrarh 521 17 fidaxomicin fidaxomicin NNS cord-345222-otfnrarh 521 18 than than IN cord-345222-otfnrarh 521 19 with with IN cord-345222-otfnrarh 521 20 vancomycin vancomycin NNS cord-345222-otfnrarh 521 21 . . . cord-345222-otfnrarh 522 1 [ [ -LRB- cord-345222-otfnrarh 522 2 155 155 CD cord-345222-otfnrarh 522 3 ] ] -RRB- cord-345222-otfnrarh 522 4 [ [ -LRB- cord-345222-otfnrarh 522 5 156 156 CD cord-345222-otfnrarh 522 6 ] ] -RRB- cord-345222-otfnrarh 522 7 [ [ -LRB- cord-345222-otfnrarh 522 8 157 157 CD cord-345222-otfnrarh 522 9 ] ] -RRB- cord-345222-otfnrarh 522 10 [ [ -LRB- cord-345222-otfnrarh 522 11 158 158 CD cord-345222-otfnrarh 522 12 ] ] -RRB- cord-345222-otfnrarh 523 1 A a DT cord-345222-otfnrarh 523 2 vaccine vaccine NN cord-345222-otfnrarh 523 3 against against IN cord-345222-otfnrarh 523 4 C. C. NNP cord-345222-otfnrarh 523 5 difficile difficile NNP cord-345222-otfnrarh 523 6 is be VBZ cord-345222-otfnrarh 523 7 desirable desirable JJ cord-345222-otfnrarh 523 8 and and CC cord-345222-otfnrarh 523 9 being be VBG cord-345222-otfnrarh 523 10 developed develop VBN cord-345222-otfnrarh 523 11 for for IN cord-345222-otfnrarh 523 12 prevention prevention NN cord-345222-otfnrarh 523 13 . . . cord-345222-otfnrarh 524 1 159 159 CD cord-345222-otfnrarh 525 1 Regarding regard VBG cord-345222-otfnrarh 525 2 Enterobacteriaceae Enterobacteriaceae NNP cord-345222-otfnrarh 525 3 , , , cord-345222-otfnrarh 525 4 an an DT cord-345222-otfnrarh 525 5 antibiotic antibiotic JJ cord-345222-otfnrarh 525 6 - - HYPH cord-345222-otfnrarh 525 7 susceptibility susceptibility NN cord-345222-otfnrarh 525 8 profile profile NN cord-345222-otfnrarh 526 1 indicated indicate VBD cord-345222-otfnrarh 526 2 that that IN cord-345222-otfnrarh 526 3 enteropathogens enteropathogen NNS cord-345222-otfnrarh 526 4 are be VBP cord-345222-otfnrarh 526 5 generally generally RB cord-345222-otfnrarh 526 6 susceptible susceptible JJ cord-345222-otfnrarh 526 7 to to IN cord-345222-otfnrarh 526 8 meropenem meropenem NNP cord-345222-otfnrarh 526 9 and and CC cord-345222-otfnrarh 526 10 ceftriaxone ceftriaxone NN cord-345222-otfnrarh 526 11 , , , cord-345222-otfnrarh 526 12 followed follow VBN cord-345222-otfnrarh 526 13 by by IN cord-345222-otfnrarh 526 14 amikacin amikacin NNS cord-345222-otfnrarh 526 15 and and CC cord-345222-otfnrarh 526 16 ciprofloxacin ciprofloxacin NNS cord-345222-otfnrarh 526 17 . . . cord-345222-otfnrarh 527 1 Almost almost RB cord-345222-otfnrarh 527 2 all all DT cord-345222-otfnrarh 527 3 enteropathogens enteropathogen NNS cord-345222-otfnrarh 527 4 were be VBD cord-345222-otfnrarh 527 5 resistant resistant JJ cord-345222-otfnrarh 527 6 to to IN cord-345222-otfnrarh 527 7 ampicillin ampicillin NNP cord-345222-otfnrarh 527 8 and and CC cord-345222-otfnrarh 527 9 amoxicillin amoxicillin NNP cord-345222-otfnrarh 527 10 . . . cord-345222-otfnrarh 528 1 160 160 CD cord-345222-otfnrarh 528 2 EPEC EPEC NNS cord-345222-otfnrarh 528 3 infection infection NN cord-345222-otfnrarh 528 4 is be VBZ cord-345222-otfnrarh 528 5 primarily primarily RB cord-345222-otfnrarh 528 6 a a DT cord-345222-otfnrarh 528 7 disease disease NN cord-345222-otfnrarh 528 8 of of IN cord-345222-otfnrarh 528 9 infants infant NNS cord-345222-otfnrarh 528 10 younger young JJR cord-345222-otfnrarh 528 11 than than IN cord-345222-otfnrarh 528 12 2 2 CD cord-345222-otfnrarh 528 13 years year NNS cord-345222-otfnrarh 528 14 of of IN cord-345222-otfnrarh 528 15 age age NN cord-345222-otfnrarh 528 16 , , , cord-345222-otfnrarh 528 17 often often RB cord-345222-otfnrarh 528 18 contracted contract VBD cord-345222-otfnrarh 528 19 during during IN cord-345222-otfnrarh 528 20 travel travel NN cord-345222-otfnrarh 528 21 in in IN cord-345222-otfnrarh 528 22 hot hot JJ cord-345222-otfnrarh 528 23 countries country NNS cord-345222-otfnrarh 528 24 . . . cord-345222-otfnrarh 529 1 In in IN cord-345222-otfnrarh 529 2 moderate moderate JJ cord-345222-otfnrarh 529 3 - - HYPH cord-345222-otfnrarh 529 4 severe severe JJ cord-345222-otfnrarh 529 5 forms form NNS cord-345222-otfnrarh 529 6 of of IN cord-345222-otfnrarh 529 7 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 529 8 caused cause VBN cord-345222-otfnrarh 529 9 by by IN cord-345222-otfnrarh 529 10 EPEC EPEC NNS cord-345222-otfnrarh 529 11 in in IN cord-345222-otfnrarh 529 12 nurseries nursery NNS cord-345222-otfnrarh 529 13 , , , cord-345222-otfnrarh 529 14 the the DT cord-345222-otfnrarh 529 15 use use NN cord-345222-otfnrarh 529 16 of of IN cord-345222-otfnrarh 529 17 antibiotics antibiotic NNS cord-345222-otfnrarh 529 18 such such JJ cord-345222-otfnrarh 529 19 as as IN cord-345222-otfnrarh 529 20 imipenem imipenem NNP cord-345222-otfnrarh 529 21 , , , cord-345222-otfnrarh 529 22 amikacin amikacin NNS cord-345222-otfnrarh 529 23 , , , cord-345222-otfnrarh 529 24 gentamicin gentamicin NNP cord-345222-otfnrarh 529 25 , , , cord-345222-otfnrarh 529 26 and and CC cord-345222-otfnrarh 529 27 fluoroquinolone fluoroquinolone NN cord-345222-otfnrarh 529 28 seem seem VBP cord-345222-otfnrarh 529 29 to to TO cord-345222-otfnrarh 529 30 be be VB cord-345222-otfnrarh 529 31 useful useful JJ cord-345222-otfnrarh 529 32 in in IN cord-345222-otfnrarh 529 33 reducing reduce VBG cord-345222-otfnrarh 529 34 morbidity morbidity NN cord-345222-otfnrarh 529 35 , , , cord-345222-otfnrarh 529 36 mortality mortality NN cord-345222-otfnrarh 529 37 , , , cord-345222-otfnrarh 529 38 and and CC cord-345222-otfnrarh 529 39 time time NN cord-345222-otfnrarh 529 40 of of IN cord-345222-otfnrarh 529 41 excretion excretion NN cord-345222-otfnrarh 529 42 , , , cord-345222-otfnrarh 529 43 but but CC cord-345222-otfnrarh 529 44 few few JJ cord-345222-otfnrarh 529 45 studies study NNS cord-345222-otfnrarh 529 46 have have VBP cord-345222-otfnrarh 529 47 evaluated evaluate VBN cord-345222-otfnrarh 529 48 in in IN cord-345222-otfnrarh 529 49 a a DT cord-345222-otfnrarh 529 50 systematic systematic JJ cord-345222-otfnrarh 529 51 manner manner NN cord-345222-otfnrarh 529 52 the the DT cord-345222-otfnrarh 529 53 value value NN cord-345222-otfnrarh 529 54 of of IN cord-345222-otfnrarh 529 55 antimicrobials antimicrobial NNS cord-345222-otfnrarh 529 56 for for IN cord-345222-otfnrarh 529 57 the the DT cord-345222-otfnrarh 529 58 management management NN cord-345222-otfnrarh 529 59 of of IN cord-345222-otfnrarh 529 60 EPEC EPEC NNP cord-345222-otfnrarh 529 61 infection infection NN cord-345222-otfnrarh 529 62 in in IN cord-345222-otfnrarh 529 63 children child NNS cord-345222-otfnrarh 529 64 . . . cord-345222-otfnrarh 530 1 161 161 CD cord-345222-otfnrarh 530 2 , , , cord-345222-otfnrarh 530 3 162 162 CD cord-345222-otfnrarh 530 4 ETEC ETEC NNP cord-345222-otfnrarh 530 5 has have VBZ cord-345222-otfnrarh 530 6 been be VBN cord-345222-otfnrarh 530 7 reported report VBN cord-345222-otfnrarh 530 8 to to TO cord-345222-otfnrarh 530 9 be be VB cord-345222-otfnrarh 530 10 the the DT cord-345222-otfnrarh 530 11 most most RBS cord-345222-otfnrarh 530 12 important important JJ cord-345222-otfnrarh 530 13 pathogen pathogen NN cord-345222-otfnrarh 530 14 responsible responsible JJ cord-345222-otfnrarh 530 15 in in IN cord-345222-otfnrarh 530 16 traveler traveler NN cord-345222-otfnrarh 530 17 's 's POS cord-345222-otfnrarh 530 18 diarrhea diarrhea NN cord-345222-otfnrarh 530 19 . . . cord-345222-otfnrarh 531 1 EAEC EAEC NNP cord-345222-otfnrarh 531 2 also also RB cord-345222-otfnrarh 531 3 plays play VBZ cord-345222-otfnrarh 531 4 an an DT cord-345222-otfnrarh 531 5 important important JJ cord-345222-otfnrarh 531 6 role role NN cord-345222-otfnrarh 531 7 in in IN cord-345222-otfnrarh 531 8 traveler traveler NN cord-345222-otfnrarh 531 9 's 's POS cord-345222-otfnrarh 531 10 diarrhea diarrhea NN cord-345222-otfnrarh 531 11 . . . cord-345222-otfnrarh 532 1 Pathogen pathogen NN cord-345222-otfnrarh 532 2 - - HYPH cord-345222-otfnrarh 532 3 and and CC cord-345222-otfnrarh 532 4 geographic geographic NN cord-345222-otfnrarh 532 5 - - HYPH cord-345222-otfnrarh 532 6 based base VBN cord-345222-otfnrarh 532 7 approaches approach NNS cord-345222-otfnrarh 532 8 to to IN cord-345222-otfnrarh 532 9 traveler traveler NN cord-345222-otfnrarh 532 10 's 's POS cord-345222-otfnrarh 532 11 diarrhea diarrhea NN cord-345222-otfnrarh 532 12 treatment treatment NN cord-345222-otfnrarh 532 13 should should MD cord-345222-otfnrarh 532 14 be be VB cord-345222-otfnrarh 532 15 encouraged encourage VBN cord-345222-otfnrarh 532 16 . . . cord-345222-otfnrarh 533 1 Fluoroquinolones fluoroquinolone NNS cord-345222-otfnrarh 533 2 and and CC cord-345222-otfnrarh 533 3 nonabsorbable nonabsorbable NNP cord-345222-otfnrarh 533 4 rifaximin rifaximin NNP cord-345222-otfnrarh 533 5 are be VBP cord-345222-otfnrarh 533 6 the the DT cord-345222-otfnrarh 533 7 drugs drug NNS cord-345222-otfnrarh 533 8 of of IN cord-345222-otfnrarh 533 9 choice choice NN cord-345222-otfnrarh 533 10 for for IN cord-345222-otfnrarh 533 11 travelers traveler NNS cord-345222-otfnrarh 533 12 to to IN cord-345222-otfnrarh 533 13 high high JJ cord-345222-otfnrarh 533 14 - - HYPH cord-345222-otfnrarh 533 15 risk risk NN cord-345222-otfnrarh 533 16 areas area NNS cord-345222-otfnrarh 533 17 in in IN cord-345222-otfnrarh 533 18 which which WDT cord-345222-otfnrarh 533 19 E. E. NNP cord-345222-otfnrarh 533 20 coli coli NNS cord-345222-otfnrarh 533 21 is be VBZ cord-345222-otfnrarh 533 22 the the DT cord-345222-otfnrarh 533 23 predominant predominant JJ cord-345222-otfnrarh 533 24 etiologic etiologic JJ cord-345222-otfnrarh 533 25 agent agent NN cord-345222-otfnrarh 533 26 ( ( -LRB- cord-345222-otfnrarh 533 27 Latin Latin NNP cord-345222-otfnrarh 533 28 America America NNP cord-345222-otfnrarh 533 29 , , , cord-345222-otfnrarh 533 30 the the DT cord-345222-otfnrarh 533 31 Caribbean Caribbean NNP cord-345222-otfnrarh 533 32 [ [ -LRB- cord-345222-otfnrarh 533 33 Haiti Haiti NNP cord-345222-otfnrarh 533 34 and and CC cord-345222-otfnrarh 533 35 the the DT cord-345222-otfnrarh 533 36 Dominican Dominican NNP cord-345222-otfnrarh 533 37 Republic Republic NNP cord-345222-otfnrarh 533 38 ] ] -RRB- cord-345222-otfnrarh 533 39 , , , cord-345222-otfnrarh 533 40 and and CC cord-345222-otfnrarh 533 41 Africa Africa NNP cord-345222-otfnrarh 533 42 ) ) -RRB- cord-345222-otfnrarh 533 43 , , , cord-345222-otfnrarh 533 44 leaving leave VBG cord-345222-otfnrarh 533 45 azithromycin azithromycin NN cord-345222-otfnrarh 533 46 for for IN cord-345222-otfnrarh 533 47 travelers traveler NNS cord-345222-otfnrarh 533 48 to to IN cord-345222-otfnrarh 533 49 South South NNP cord-345222-otfnrarh 533 50 and and CC cord-345222-otfnrarh 533 51 Southeast Southeast NNP cord-345222-otfnrarh 533 52 Asia Asia NNP cord-345222-otfnrarh 533 53 as as RB cord-345222-otfnrarh 533 54 well well RB cord-345222-otfnrarh 533 55 as as IN cord-345222-otfnrarh 533 56 patients patient NNS cord-345222-otfnrarh 533 57 with with IN cord-345222-otfnrarh 533 58 febrile febrile JJ cord-345222-otfnrarh 533 59 dysenteric dysenteric JJ cord-345222-otfnrarh 533 60 illnesses illness NNS cord-345222-otfnrarh 533 61 acquired acquire VBN cord-345222-otfnrarh 533 62 in in IN cord-345222-otfnrarh 533 63 any any DT cord-345222-otfnrarh 533 64 region region NN cord-345222-otfnrarh 533 65 . . . cord-345222-otfnrarh 534 1 163 163 CD cord-345222-otfnrarh 534 2 Antibiotic antibiotic JJ cord-345222-otfnrarh 534 3 therapy therapy NN cord-345222-otfnrarh 534 4 for for IN cord-345222-otfnrarh 534 5 STEC STEC NNP cord-345222-otfnrarh 534 6 is be VBZ cord-345222-otfnrarh 534 7 complicated complicated JJ cord-345222-otfnrarh 534 8 . . . cord-345222-otfnrarh 535 1 The the DT cord-345222-otfnrarh 535 2 growth growth NN cord-345222-otfnrarh 535 3 of of IN cord-345222-otfnrarh 535 4 O157 O157 NNP cord-345222-otfnrarh 535 5 : : : cord-345222-otfnrarh 535 6 H7 h7 NN cord-345222-otfnrarh 535 7 in in IN cord-345222-otfnrarh 535 8 the the DT cord-345222-otfnrarh 535 9 intestinal intestinal JJ cord-345222-otfnrarh 535 10 tract tract NN cord-345222-otfnrarh 535 11 leads lead VBZ cord-345222-otfnrarh 535 12 to to IN cord-345222-otfnrarh 535 13 diarrhea diarrhea VB cord-345222-otfnrarh 535 14 , , , cord-345222-otfnrarh 535 15 and and CC cord-345222-otfnrarh 535 16 patients patient NNS cord-345222-otfnrarh 535 17 would would MD cord-345222-otfnrarh 535 18 presumably presumably RB cord-345222-otfnrarh 535 19 benefit benefit VB cord-345222-otfnrarh 535 20 if if IN cord-345222-otfnrarh 535 21 antibiotic antibiotic JJ cord-345222-otfnrarh 535 22 treatment treatment NN cord-345222-otfnrarh 535 23 eliminated eliminate VBD cord-345222-otfnrarh 535 24 the the DT cord-345222-otfnrarh 535 25 bacteria bacteria NNS cord-345222-otfnrarh 535 26 . . . cord-345222-otfnrarh 536 1 However however RB cord-345222-otfnrarh 536 2 , , , cord-345222-otfnrarh 536 3 systemic systemic JJ cord-345222-otfnrarh 536 4 dissemination dissemination NN cord-345222-otfnrarh 536 5 of of IN cord-345222-otfnrarh 536 6 Shiga Shiga NNP cord-345222-otfnrarh 536 7 toxin toxin NN cord-345222-otfnrarh 536 8 type type NN cord-345222-otfnrarh 536 9 2 2 CD cord-345222-otfnrarh 536 10 produced produce VBN cord-345222-otfnrarh 536 11 by by IN cord-345222-otfnrarh 536 12 the the DT cord-345222-otfnrarh 536 13 bacteria bacteria NNS cord-345222-otfnrarh 536 14 in in IN cord-345222-otfnrarh 536 15 the the DT cord-345222-otfnrarh 536 16 intestinal intestinal JJ cord-345222-otfnrarh 536 17 tract tract NN cord-345222-otfnrarh 536 18 can can MD cord-345222-otfnrarh 536 19 lead lead VB cord-345222-otfnrarh 536 20 to to IN cord-345222-otfnrarh 536 21 life life NN cord-345222-otfnrarh 536 22 - - HYPH cord-345222-otfnrarh 536 23 threatening threaten VBG cord-345222-otfnrarh 536 24 complications complication NNS cord-345222-otfnrarh 536 25 , , , cord-345222-otfnrarh 536 26 including include VBG cord-345222-otfnrarh 536 27 neurological neurological JJ cord-345222-otfnrarh 536 28 damage damage NN cord-345222-otfnrarh 536 29 and and CC cord-345222-otfnrarh 536 30 HUS hus NN cord-345222-otfnrarh 536 31 . . . cord-345222-otfnrarh 537 1 Antibiotic antibiotic JJ cord-345222-otfnrarh 537 2 treatments treatment NNS cord-345222-otfnrarh 537 3 that that WDT cord-345222-otfnrarh 537 4 induce induce VBP cord-345222-otfnrarh 537 5 the the DT cord-345222-otfnrarh 537 6 phage phage NN cord-345222-otfnrarh 537 7 lytic lytic JJ cord-345222-otfnrarh 537 8 cycle cycle NN cord-345222-otfnrarh 537 9 , , , cord-345222-otfnrarh 537 10 resulting result VBG cord-345222-otfnrarh 537 11 in in IN cord-345222-otfnrarh 537 12 increased increase VBN cord-345222-otfnrarh 537 13 Shiga shiga JJ cord-345222-otfnrarh 537 14 toxin toxin NN cord-345222-otfnrarh 537 15 production production NN cord-345222-otfnrarh 537 16 , , , cord-345222-otfnrarh 537 17 could could MD cord-345222-otfnrarh 537 18 lead lead VB cord-345222-otfnrarh 537 19 to to IN cord-345222-otfnrarh 537 20 more more RBR cord-345222-otfnrarh 537 21 serious serious JJ cord-345222-otfnrarh 537 22 disease disease NN cord-345222-otfnrarh 537 23 . . . cord-345222-otfnrarh 538 1 Recent recent JJ cord-345222-otfnrarh 538 2 studies study NNS cord-345222-otfnrarh 538 3 suggest suggest VBP cord-345222-otfnrarh 538 4 that that IN cord-345222-otfnrarh 538 5 normal normal JJ cord-345222-otfnrarh 538 6 flora flora NNS cord-345222-otfnrarh 538 7 can can MD cord-345222-otfnrarh 538 8 have have VB cord-345222-otfnrarh 538 9 a a DT cord-345222-otfnrarh 538 10 profound profound JJ cord-345222-otfnrarh 538 11 impact impact NN cord-345222-otfnrarh 538 12 on on IN cord-345222-otfnrarh 538 13 Shiga Shiga NNP cord-345222-otfnrarh 538 14 toxin toxin NN cord-345222-otfnrarh 538 15 production production NN cord-345222-otfnrarh 538 16 . . . cord-345222-otfnrarh 539 1 Subinhibitory subinhibitory JJ cord-345222-otfnrarh 539 2 levels level NNS cord-345222-otfnrarh 539 3 of of IN cord-345222-otfnrarh 539 4 antibiotics antibiotic NNS cord-345222-otfnrarh 539 5 that that WDT cord-345222-otfnrarh 539 6 target target VBP cord-345222-otfnrarh 539 7 DNA dna NN cord-345222-otfnrarh 539 8 synthesis synthesis NN cord-345222-otfnrarh 539 9 , , , cord-345222-otfnrarh 539 10 including include VBG cord-345222-otfnrarh 539 11 ciprofloxacin ciprofloxacin NN cord-345222-otfnrarh 539 12 and and CC cord-345222-otfnrarh 539 13 sulfamethoxazole sulfamethoxazole NNP cord-345222-otfnrarh 539 14 - - HYPH cord-345222-otfnrarh 539 15 trimethoprim trimethoprim NNP cord-345222-otfnrarh 539 16 , , , cord-345222-otfnrarh 539 17 increased increase VBD cord-345222-otfnrarh 539 18 Shiga Shiga NNP cord-345222-otfnrarh 539 19 toxin toxin NN cord-345222-otfnrarh 539 20 production production NN cord-345222-otfnrarh 539 21 , , , cord-345222-otfnrarh 539 22 while while IN cord-345222-otfnrarh 539 23 antibiotics antibiotic NNS cord-345222-otfnrarh 539 24 that that WDT cord-345222-otfnrarh 539 25 target target VBP cord-345222-otfnrarh 539 26 the the DT cord-345222-otfnrarh 539 27 cell cell NN cord-345222-otfnrarh 539 28 wall wall NN cord-345222-otfnrarh 539 29 , , , cord-345222-otfnrarh 539 30 transcription transcription NN cord-345222-otfnrarh 539 31 , , , cord-345222-otfnrarh 539 32 or or CC cord-345222-otfnrarh 539 33 translation translation NN cord-345222-otfnrarh 539 34 did do VBD cord-345222-otfnrarh 539 35 not not RB cord-345222-otfnrarh 539 36 . . . cord-345222-otfnrarh 540 1 So so RB cord-345222-otfnrarh 540 2 ciprofloxacin ciprofloxacin NNP cord-345222-otfnrarh 540 3 and and CC cord-345222-otfnrarh 540 4 sulfamethoxazole sulfamethoxazole NNP cord-345222-otfnrarh 540 5 - - HYPH cord-345222-otfnrarh 540 6 trimethoprim trimethoprim NNP cord-345222-otfnrarh 540 7 are be VBP cord-345222-otfnrarh 540 8 not not RB cord-345222-otfnrarh 540 9 appropriate appropriate JJ cord-345222-otfnrarh 540 10 for for IN cord-345222-otfnrarh 540 11 treatment treatment NN cord-345222-otfnrarh 540 12 of of IN cord-345222-otfnrarh 540 13 O157 O157 NNP cord-345222-otfnrarh 540 14 : : : cord-345222-otfnrarh 541 1 H7 H7 NNP cord-345222-otfnrarh 541 2 . . . cord-345222-otfnrarh 542 1 In in IN cord-345222-otfnrarh 542 2 contrast contrast NN cord-345222-otfnrarh 542 3 , , , cord-345222-otfnrarh 542 4 azithromycin azithromycin NN cord-345222-otfnrarh 542 5 significantly significantly RB cord-345222-otfnrarh 542 6 reduced reduce VBD cord-345222-otfnrarh 542 7 Shiga Shiga NNP cord-345222-otfnrarh 542 8 toxin toxin NN cord-345222-otfnrarh 542 9 levels level NNS cord-345222-otfnrarh 542 10 , , , cord-345222-otfnrarh 542 11 even even RB cord-345222-otfnrarh 542 12 when when WRB cord-345222-otfnrarh 542 13 relatively relatively RB cord-345222-otfnrarh 542 14 high high JJ cord-345222-otfnrarh 542 15 levels level NNS cord-345222-otfnrarh 542 16 of of IN cord-345222-otfnrarh 542 17 O157 O157 NNP cord-345222-otfnrarh 542 18 : : : cord-345222-otfnrarh 543 1 H7 H7 NNP cord-345222-otfnrarh 543 2 were be VBD cord-345222-otfnrarh 543 3 recovered recover VBN cord-345222-otfnrarh 543 4 . . . cord-345222-otfnrarh 544 1 164 164 CD cord-345222-otfnrarh 545 1 Moreover moreover RB cord-345222-otfnrarh 545 2 , , , cord-345222-otfnrarh 545 3 the the DT cord-345222-otfnrarh 545 4 eradication eradication NN cord-345222-otfnrarh 545 5 rate rate NN cord-345222-otfnrarh 545 6 reported report VBN cord-345222-otfnrarh 545 7 in in IN cord-345222-otfnrarh 545 8 STEC STEC NNP cord-345222-otfnrarh 545 9 O104 O104 NNP cord-345222-otfnrarh 545 10 : : : cord-345222-otfnrarh 545 11 H4 H4 NNP cord-345222-otfnrarh 545 12 infections infection NNS cord-345222-otfnrarh 545 13 is be VBZ cord-345222-otfnrarh 545 14 86 86 CD cord-345222-otfnrarh 545 15 % % NN cord-345222-otfnrarh 545 16 . . . cord-345222-otfnrarh 546 1 Azithromycin Azithromycin NNP cord-345222-otfnrarh 546 2 might may MD cord-345222-otfnrarh 546 3 be be VB cord-345222-otfnrarh 546 4 considered consider VBN cord-345222-otfnrarh 546 5 a a DT cord-345222-otfnrarh 546 6 potentially potentially RB cord-345222-otfnrarh 546 7 effective effective JJ cord-345222-otfnrarh 546 8 and and CC cord-345222-otfnrarh 546 9 safe safe JJ cord-345222-otfnrarh 546 10 antibiotic antibiotic NN cord-345222-otfnrarh 546 11 , , , cord-345222-otfnrarh 546 12 and and CC cord-345222-otfnrarh 546 13 may may MD cord-345222-otfnrarh 546 14 be be VB cord-345222-otfnrarh 546 15 used use VBN cord-345222-otfnrarh 546 16 safely safely RB cord-345222-otfnrarh 546 17 for for IN cord-345222-otfnrarh 546 18 decolonization decolonization NN cord-345222-otfnrarh 546 19 of of IN cord-345222-otfnrarh 546 20 STEC STEC NNP cord-345222-otfnrarh 546 21 O104 O104 NNP cord-345222-otfnrarh 546 22 : : : cord-345222-otfnrarh 547 1 H4 H4 NNP cord-345222-otfnrarh 547 2 long long JJ cord-345222-otfnrarh 547 3 - - HYPH cord-345222-otfnrarh 547 4 term term NN cord-345222-otfnrarh 547 5 carriage carriage NN cord-345222-otfnrarh 547 6 . . . cord-345222-otfnrarh 548 1 165 165 CD cord-345222-otfnrarh 549 1 Numerous numerous JJ cord-345222-otfnrarh 549 2 outbreaks outbreak NNS cord-345222-otfnrarh 549 3 , , , cord-345222-otfnrarh 549 4 as as RB cord-345222-otfnrarh 549 5 well well RB cord-345222-otfnrarh 549 6 as as IN cord-345222-otfnrarh 549 7 sporadic sporadic JJ cord-345222-otfnrarh 549 8 cases case NNS cord-345222-otfnrarh 549 9 of of IN cord-345222-otfnrarh 549 10 STEC STEC NNP cord-345222-otfnrarh 549 11 infections infection NNS cord-345222-otfnrarh 549 12 and and CC cord-345222-otfnrarh 549 13 HUS HUS NNP cord-345222-otfnrarh 549 14 , , , cord-345222-otfnrarh 549 15 have have VBP cord-345222-otfnrarh 549 16 been be VBN cord-345222-otfnrarh 549 17 documented document VBN cord-345222-otfnrarh 549 18 worldwide worldwide RB cord-345222-otfnrarh 549 19 . . . cord-345222-otfnrarh 550 1 There there EX cord-345222-otfnrarh 550 2 are be VBP cord-345222-otfnrarh 550 3 numerous numerous JJ cord-345222-otfnrarh 550 4 reports report NNS cord-345222-otfnrarh 550 5 on on IN cord-345222-otfnrarh 550 6 STEC STEC NNP cord-345222-otfnrarh 550 7 O157 O157 NNP cord-345222-otfnrarh 550 8 : : : cord-345222-otfnrarh 551 1 H7 H7 NNP cord-345222-otfnrarh 551 2 as as IN cord-345222-otfnrarh 551 3 the the DT cord-345222-otfnrarh 551 4 most most RBS cord-345222-otfnrarh 551 5 common common JJ cord-345222-otfnrarh 551 6 serotype serotype NN cord-345222-otfnrarh 551 7 associated associate VBN cord-345222-otfnrarh 551 8 with with IN cord-345222-otfnrarh 551 9 HUS HUS NNP cord-345222-otfnrarh 551 10 , , , cord-345222-otfnrarh 551 11 especially especially RB cord-345222-otfnrarh 551 12 in in IN cord-345222-otfnrarh 551 13 children child NNS cord-345222-otfnrarh 551 14 . . . cord-345222-otfnrarh 552 1 Several several JJ cord-345222-otfnrarh 552 2 reports report NNS cord-345222-otfnrarh 552 3 on on IN cord-345222-otfnrarh 552 4 non non AFX cord-345222-otfnrarh 552 5 - - JJ cord-345222-otfnrarh 552 6 O157 o157 JJ cord-345222-otfnrarh 552 7 STEC STEC NNP cord-345222-otfnrarh 552 8 underline underline VBP cord-345222-otfnrarh 552 9 their -PRON- PRP$ cord-345222-otfnrarh 552 10 potential potential NN cord-345222-otfnrarh 552 11 to to TO cord-345222-otfnrarh 552 12 cause cause VB cord-345222-otfnrarh 552 13 sporadic sporadic JJ cord-345222-otfnrarh 552 14 disease disease NN cord-345222-otfnrarh 552 15 as as RB cord-345222-otfnrarh 552 16 well well RB cord-345222-otfnrarh 552 17 as as IN cord-345222-otfnrarh 552 18 epidemics epidemic NNS cord-345222-otfnrarh 552 19 . . . cord-345222-otfnrarh 553 1 During during IN cord-345222-otfnrarh 553 2 2011 2011 CD cord-345222-otfnrarh 553 3 , , , cord-345222-otfnrarh 553 4 there there EX cord-345222-otfnrarh 553 5 was be VBD cord-345222-otfnrarh 553 6 a a DT cord-345222-otfnrarh 553 7 large large JJ cord-345222-otfnrarh 553 8 outbreak outbreak NN cord-345222-otfnrarh 553 9 in in IN cord-345222-otfnrarh 553 10 Northern Northern NNP cord-345222-otfnrarh 553 11 Germany Germany NNP cord-345222-otfnrarh 553 12 , , , cord-345222-otfnrarh 553 13 with with IN cord-345222-otfnrarh 553 14 a a DT cord-345222-otfnrarh 553 15 satellite satellite NN cord-345222-otfnrarh 553 16 outbreak outbreak NN cord-345222-otfnrarh 553 17 in in IN cord-345222-otfnrarh 553 18 Western Western NNP cord-345222-otfnrarh 553 19 France France NNP cord-345222-otfnrarh 553 20 caused cause VBN cord-345222-otfnrarh 553 21 by by IN cord-345222-otfnrarh 553 22 an an DT cord-345222-otfnrarh 553 23 EAEC EAEC NNP cord-345222-otfnrarh 553 24 of of IN cord-345222-otfnrarh 553 25 serotype serotype NN cord-345222-otfnrarh 553 26 O104 o104 CD cord-345222-otfnrarh 553 27 : : : cord-345222-otfnrarh 554 1 H4 H4 NNP cord-345222-otfnrarh 554 2 expressing express VBG cord-345222-otfnrarh 554 3 a a DT cord-345222-otfnrarh 554 4 phage phage NN cord-345222-otfnrarh 554 5 - - HYPH cord-345222-otfnrarh 554 6 encoded encode VBN cord-345222-otfnrarh 554 7 Shiga Shiga NNP cord-345222-otfnrarh 554 8 toxin toxin NN cord-345222-otfnrarh 554 9 2 2 CD cord-345222-otfnrarh 554 10 : : : cord-345222-otfnrarh 555 1 clinicians clinician NNS cord-345222-otfnrarh 555 2 were be VBD cord-345222-otfnrarh 555 3 confronted confront VBN cord-345222-otfnrarh 555 4 with with IN cord-345222-otfnrarh 555 5 a a DT cord-345222-otfnrarh 555 6 large large JJ cord-345222-otfnrarh 555 7 number number NN cord-345222-otfnrarh 555 8 of of IN cord-345222-otfnrarh 555 9 mainly mainly RB cord-345222-otfnrarh 555 10 adult adult NN cord-345222-otfnrarh 555 11 patients patient NNS cord-345222-otfnrarh 555 12 with with IN cord-345222-otfnrarh 555 13 HUS HUS NNP cord-345222-otfnrarh 555 14 associated associate VBN cord-345222-otfnrarh 555 15 with with IN cord-345222-otfnrarh 555 16 severe severe JJ cord-345222-otfnrarh 555 17 hemolysis hemolysis NN cord-345222-otfnrarh 555 18 and and CC cord-345222-otfnrarh 555 19 neurological neurological JJ cord-345222-otfnrarh 555 20 complications complication NNS cord-345222-otfnrarh 555 21 . . . cord-345222-otfnrarh 556 1 166 166 CD cord-345222-otfnrarh 556 2 Medical medical JJ cord-345222-otfnrarh 556 3 centers center NNS cord-345222-otfnrarh 556 4 used use VBD cord-345222-otfnrarh 556 5 varying vary VBG cord-345222-otfnrarh 556 6 therapeutic therapeutic JJ cord-345222-otfnrarh 556 7 regimens regimen NNS cord-345222-otfnrarh 556 8 , , , cord-345222-otfnrarh 556 9 including include VBG cord-345222-otfnrarh 556 10 plasmapheresis plasmapheresis NN cord-345222-otfnrarh 556 11 , , , cord-345222-otfnrarh 556 12 glucocorticoids glucocorticoid NNS cord-345222-otfnrarh 556 13 , , , cord-345222-otfnrarh 556 14 and and CC cord-345222-otfnrarh 556 15 the the DT cord-345222-otfnrarh 556 16 submit submit NN cord-345222-otfnrarh 556 17 your -PRON- PRP$ cord-345222-otfnrarh 556 18 manuscript manuscript NN cord-345222-otfnrarh 556 19 | | POS cord-345222-otfnrarh 556 20 www.dovepress.com www.dovepress.com ADD cord-345222-otfnrarh 557 1 Dovepress Dovepress NNP cord-345222-otfnrarh 557 2 Dovepress Dovepress NNP cord-345222-otfnrarh 557 3 anti anti JJ cord-345222-otfnrarh 557 4 - - JJ cord-345222-otfnrarh 557 5 C5 c5 JJ cord-345222-otfnrarh 557 6 monoclonal monoclonal JJ cord-345222-otfnrarh 557 7 antibody antibody NN cord-345222-otfnrarh 557 8 eculizumab eculizumab NNS cord-345222-otfnrarh 557 9 , , , cord-345222-otfnrarh 557 10 but but CC cord-345222-otfnrarh 558 1 currently currently RB cord-345222-otfnrarh 558 2 there there EX cord-345222-otfnrarh 558 3 is be VBZ cord-345222-otfnrarh 558 4 no no DT cord-345222-otfnrarh 558 5 effective effective JJ cord-345222-otfnrarh 558 6 prophylaxis prophylaxis NN cord-345222-otfnrarh 558 7 or or CC cord-345222-otfnrarh 558 8 treatment treatment NN cord-345222-otfnrarh 558 9 available available JJ cord-345222-otfnrarh 558 10 for for IN cord-345222-otfnrarh 558 11 STEC STEC NNP cord-345222-otfnrarh 558 12 infections infection NNS cord-345222-otfnrarh 558 13 and and CC cord-345222-otfnrarh 558 14 HUS hus NN cord-345222-otfnrarh 558 15 . . . cord-345222-otfnrarh 559 1 166 166 CD cord-345222-otfnrarh 560 1 The the DT cord-345222-otfnrarh 560 2 probiotic probiotic JJ cord-345222-otfnrarh 560 3 Escherichia escherichia NN cord-345222-otfnrarh 560 4 coli coli NNS cord-345222-otfnrarh 560 5 strain strain VBP cord-345222-otfnrarh 560 6 Nissle Nissle NNP cord-345222-otfnrarh 560 7 1917 1917 CD cord-345222-otfnrarh 560 8 ( ( -LRB- cord-345222-otfnrarh 560 9 EcN EcN NNP cord-345222-otfnrarh 560 10 ) ) -RRB- cord-345222-otfnrarh 560 11 seemed seem VBD cord-345222-otfnrarh 560 12 to to TO cord-345222-otfnrarh 560 13 have have VB cord-345222-otfnrarh 560 14 very very RB cord-345222-otfnrarh 560 15 efficient efficient JJ cord-345222-otfnrarh 560 16 antagonistic antagonistic JJ cord-345222-otfnrarh 560 17 activity activity NN cord-345222-otfnrarh 560 18 on on IN cord-345222-otfnrarh 560 19 the the DT cord-345222-otfnrarh 560 20 EHEC EHEC NNP cord-345222-otfnrarh 560 21 strains strain NNS cord-345222-otfnrarh 560 22 of of IN cord-345222-otfnrarh 560 23 serotype serotype NN cord-345222-otfnrarh 560 24 O104 o104 CD cord-345222-otfnrarh 560 25 : : : cord-345222-otfnrarh 561 1 H4 H4 NNP cord-345222-otfnrarh 561 2 and and CC cord-345222-otfnrarh 561 3 O157 O157 NNP cord-345222-otfnrarh 561 4 : : : cord-345222-otfnrarh 561 5 H7 H7 NNP cord-345222-otfnrarh 561 6 , , , cord-345222-otfnrarh 561 7 with with IN cord-345222-otfnrarh 561 8 reduced reduce VBN cord-345222-otfnrarh 561 9 growth growth NN cord-345222-otfnrarh 561 10 of of IN cord-345222-otfnrarh 561 11 pathogens pathogen NNS cord-345222-otfnrarh 561 12 . . . cord-345222-otfnrarh 562 1 167 167 CD cord-345222-otfnrarh 563 1 The the DT cord-345222-otfnrarh 563 2 2011 2011 CD cord-345222-otfnrarh 563 3 outbreak outbreak NN cord-345222-otfnrarh 563 4 strains strain NNS cord-345222-otfnrarh 563 5 perfectly perfectly RB cord-345222-otfnrarh 563 6 showed show VBD cord-345222-otfnrarh 563 7 the the DT cord-345222-otfnrarh 563 8 genome genome NN cord-345222-otfnrarh 563 9 plasticity plasticity NN cord-345222-otfnrarh 563 10 and and CC cord-345222-otfnrarh 563 11 evolution evolution NN cord-345222-otfnrarh 563 12 of of IN cord-345222-otfnrarh 563 13 E. E. NNP cord-345222-otfnrarh 563 14 coli coli NNS cord-345222-otfnrarh 563 15 as as IN cord-345222-otfnrarh 563 16 a a DT cord-345222-otfnrarh 563 17 result result NN cord-345222-otfnrarh 563 18 of of IN cord-345222-otfnrarh 563 19 horizontal horizontal JJ cord-345222-otfnrarh 563 20 gene gene NN cord-345222-otfnrarh 563 21 transfer transfer NN cord-345222-otfnrarh 563 22 . . . cord-345222-otfnrarh 564 1 These these DT cord-345222-otfnrarh 564 2 strains strain NNS cord-345222-otfnrarh 564 3 combine combine VBP cord-345222-otfnrarh 564 4 the the DT cord-345222-otfnrarh 564 5 virulence virulence NN cord-345222-otfnrarh 564 6 mechanisms mechanism NNS cord-345222-otfnrarh 564 7 of of IN cord-345222-otfnrarh 564 8 two two CD cord-345222-otfnrarh 564 9 pathotypes pathotype NNS cord-345222-otfnrarh 564 10 ( ( -LRB- cord-345222-otfnrarh 564 11 EAEC EAEC NNP cord-345222-otfnrarh 564 12 and and CC cord-345222-otfnrarh 564 13 EHEC EHEC NNP cord-345222-otfnrarh 564 14 ) ) -RRB- cord-345222-otfnrarh 564 15 , , , cord-345222-otfnrarh 564 16 leading lead VBG cord-345222-otfnrarh 564 17 to to IN cord-345222-otfnrarh 564 18 an an DT cord-345222-otfnrarh 564 19 improved improved JJ cord-345222-otfnrarh 564 20 ability ability NN cord-345222-otfnrarh 564 21 to to TO cord-345222-otfnrarh 564 22 adhere adhere VB cord-345222-otfnrarh 564 23 to to IN cord-345222-otfnrarh 564 24 and and CC cord-345222-otfnrarh 564 25 infect infect VB cord-345222-otfnrarh 564 26 host host NN cord-345222-otfnrarh 564 27 cells cell NNS cord-345222-otfnrarh 564 28 . . . cord-345222-otfnrarh 565 1 Furthermore furthermore RB cord-345222-otfnrarh 565 2 , , , cord-345222-otfnrarh 565 3 the the DT cord-345222-otfnrarh 565 4 acquisition acquisition NN cord-345222-otfnrarh 565 5 of of IN cord-345222-otfnrarh 565 6 mechanisms mechanism NNS cord-345222-otfnrarh 565 7 mediating mediate VBG cord-345222-otfnrarh 565 8 increased increase VBN cord-345222-otfnrarh 565 9 antibiotic antibiotic JJ cord-345222-otfnrarh 565 10 resistance resistance NN cord-345222-otfnrarh 565 11 hampered hamper VBD cord-345222-otfnrarh 565 12 patient patient JJ cord-345222-otfnrarh 565 13 treatment treatment NN cord-345222-otfnrarh 565 14 and and CC cord-345222-otfnrarh 565 15 recovery recovery NN cord-345222-otfnrarh 565 16 . . . cord-345222-otfnrarh 566 1 These these DT cord-345222-otfnrarh 566 2 strains strain NNS cord-345222-otfnrarh 566 3 have have VBP cord-345222-otfnrarh 566 4 conserved conserve VBN cord-345222-otfnrarh 566 5 most most JJS cord-345222-otfnrarh 566 6 of of IN cord-345222-otfnrarh 566 7 the the DT cord-345222-otfnrarh 566 8 virulence virulence NN cord-345222-otfnrarh 566 9 factors factor NNS cord-345222-otfnrarh 566 10 of of IN cord-345222-otfnrarh 566 11 an an DT cord-345222-otfnrarh 566 12 EAEC EAEC NNP cord-345222-otfnrarh 566 13 strain strain NN cord-345222-otfnrarh 566 14 , , , cord-345222-otfnrarh 566 15 but but CC cord-345222-otfnrarh 566 16 several several JJ cord-345222-otfnrarh 566 17 mobile mobile JJ cord-345222-otfnrarh 566 18 genetic genetic JJ cord-345222-otfnrarh 566 19 elements element NNS cord-345222-otfnrarh 566 20 were be VBD cord-345222-otfnrarh 566 21 responsible responsible JJ cord-345222-otfnrarh 566 22 for for IN cord-345222-otfnrarh 566 23 the the DT cord-345222-otfnrarh 566 24 acquisition acquisition NN cord-345222-otfnrarh 566 25 of of IN cord-345222-otfnrarh 566 26 new new JJ cord-345222-otfnrarh 566 27 functions function NNS cord-345222-otfnrarh 566 28 involved involve VBN cord-345222-otfnrarh 566 29 in in IN cord-345222-otfnrarh 566 30 high high JJ cord-345222-otfnrarh 566 31 - - HYPH cord-345222-otfnrarh 566 32 frequency frequency NN cord-345222-otfnrarh 566 33 recombination recombination NN cord-345222-otfnrarh 566 34 , , , cord-345222-otfnrarh 566 35 mobilization mobilization NN cord-345222-otfnrarh 566 36 , , , cord-345222-otfnrarh 566 37 and and CC cord-345222-otfnrarh 566 38 transfer transfer NN cord-345222-otfnrarh 566 39 of of IN cord-345222-otfnrarh 566 40 genes gene NNS cord-345222-otfnrarh 566 41 . . . cord-345222-otfnrarh 567 1 Despite despite IN cord-345222-otfnrarh 567 2 the the DT cord-345222-otfnrarh 567 3 alternative alternative JJ cord-345222-otfnrarh 567 4 mechanisms mechanism NNS cord-345222-otfnrarh 567 5 that that WDT cord-345222-otfnrarh 567 6 have have VBP cord-345222-otfnrarh 567 7 evolved evolve VBN cord-345222-otfnrarh 567 8 to to TO cord-345222-otfnrarh 567 9 colonize colonize VB cord-345222-otfnrarh 567 10 and and CC cord-345222-otfnrarh 567 11 adapt adapt VB cord-345222-otfnrarh 567 12 to to IN cord-345222-otfnrarh 567 13 new new JJ cord-345222-otfnrarh 567 14 niches niche NNS cord-345222-otfnrarh 567 15 , , , cord-345222-otfnrarh 567 16 E. E. NNP cord-345222-otfnrarh 567 17 coli coli VBZ cord-345222-otfnrarh 567 18 strains strain NNS cord-345222-otfnrarh 567 19 have have VBP cord-345222-otfnrarh 567 20 maintained maintain VBN cord-345222-otfnrarh 567 21 a a DT cord-345222-otfnrarh 567 22 core core NN cord-345222-otfnrarh 567 23 genome genome NN cord-345222-otfnrarh 567 24 sequence sequence NN cord-345222-otfnrarh 567 25 , , , cord-345222-otfnrarh 567 26 and and CC cord-345222-otfnrarh 567 27 therefore therefore RB cord-345222-otfnrarh 567 28 share share VBP cord-345222-otfnrarh 567 29 several several JJ cord-345222-otfnrarh 567 30 components component NNS cord-345222-otfnrarh 567 31 that that WDT cord-345222-otfnrarh 567 32 could could MD cord-345222-otfnrarh 567 33 be be VB cord-345222-otfnrarh 567 34 useful useful JJ cord-345222-otfnrarh 567 35 targets target NNS cord-345222-otfnrarh 567 36 for for IN cord-345222-otfnrarh 567 37 a a DT cord-345222-otfnrarh 567 38 universal universal JJ cord-345222-otfnrarh 567 39 vaccine vaccine NN cord-345222-otfnrarh 567 40 against against IN cord-345222-otfnrarh 567 41 E. E. NNP cord-345222-otfnrarh 567 42 coli coli NNS cord-345222-otfnrarh 567 43 . . . cord-345222-otfnrarh 568 1 Considering consider VBG cord-345222-otfnrarh 568 2 the the DT cord-345222-otfnrarh 568 3 increasing increase VBG cord-345222-otfnrarh 568 4 antibiotic antibiotic JJ cord-345222-otfnrarh 568 5 resistance resistance NN cord-345222-otfnrarh 568 6 present present NN cord-345222-otfnrarh 568 7 among among IN cord-345222-otfnrarh 568 8 E. E. NNP cord-345222-otfnrarh 568 9 coli coli NNS cord-345222-otfnrarh 568 10 strains strain NNS cord-345222-otfnrarh 568 11 , , , cord-345222-otfnrarh 568 12 which which WDT cord-345222-otfnrarh 568 13 is be VBZ cord-345222-otfnrarh 568 14 derived derive VBN cord-345222-otfnrarh 568 15 from from IN cord-345222-otfnrarh 568 16 an an DT cord-345222-otfnrarh 568 17 uncontrolled uncontrolled JJ cord-345222-otfnrarh 568 18 use use NN cord-345222-otfnrarh 568 19 of of IN cord-345222-otfnrarh 568 20 antibiotics antibiotic NNS cord-345222-otfnrarh 568 21 , , , cord-345222-otfnrarh 568 22 vaccination vaccination NN cord-345222-otfnrarh 568 23 is be VBZ cord-345222-otfnrarh 568 24 the the DT cord-345222-otfnrarh 568 25 most most RBS cord-345222-otfnrarh 568 26 promising promising JJ cord-345222-otfnrarh 568 27 approach approach NN cord-345222-otfnrarh 568 28 to to TO cord-345222-otfnrarh 568 29 control control VB cord-345222-otfnrarh 568 30 disease disease NN cord-345222-otfnrarh 568 31 . . . cord-345222-otfnrarh 569 1 168 168 CD cord-345222-otfnrarh 570 1 Helicobacter Helicobacter NNP cord-345222-otfnrarh 570 2 pylori pylori NN cord-345222-otfnrarh 570 3 is be VBZ cord-345222-otfnrarh 570 4 a a DT cord-345222-otfnrarh 570 5 leading leading JJ cord-345222-otfnrarh 570 6 cause cause NN cord-345222-otfnrarh 570 7 of of IN cord-345222-otfnrarh 570 8 chronic chronic JJ cord-345222-otfnrarh 570 9 gastritis gastritis NN cord-345222-otfnrarh 570 10 , , , cord-345222-otfnrarh 570 11 peptic peptic JJ cord-345222-otfnrarh 570 12 ulcers ulcer NNS cord-345222-otfnrarh 570 13 , , , cord-345222-otfnrarh 570 14 nonulcer nonulcer NNP cord-345222-otfnrarh 570 15 dyspepsia dyspepsia NN cord-345222-otfnrarh 570 16 , , , cord-345222-otfnrarh 570 17 gastric gastric JJ cord-345222-otfnrarh 570 18 adenocarcinoma adenocarcinoma NN cord-345222-otfnrarh 570 19 , , , cord-345222-otfnrarh 570 20 and and CC cord-345222-otfnrarh 570 21 mucosa mucosa NN cord-345222-otfnrarh 570 22 - - HYPH cord-345222-otfnrarh 570 23 associated associate VBN cord-345222-otfnrarh 570 24 lymphoid lymphoid JJ cord-345222-otfnrarh 570 25 tissue tissue NN cord-345222-otfnrarh 570 26 lymphoma lymphoma NN cord-345222-otfnrarh 570 27 . . . cord-345222-otfnrarh 571 1 Eradication eradication NN cord-345222-otfnrarh 571 2 of of IN cord-345222-otfnrarh 571 3 the the DT cord-345222-otfnrarh 571 4 pathogen pathogen NN cord-345222-otfnrarh 571 5 has have VBZ cord-345222-otfnrarh 571 6 a a DT cord-345222-otfnrarh 571 7 failure failure NN cord-345222-otfnrarh 571 8 rate rate NN cord-345222-otfnrarh 571 9 of of IN cord-345222-otfnrarh 571 10 more more JJR cord-345222-otfnrarh 571 11 than than IN cord-345222-otfnrarh 571 12 30 30 CD cord-345222-otfnrarh 571 13 % % NN cord-345222-otfnrarh 571 14 in in IN cord-345222-otfnrarh 571 15 pediatric pediatric JJ cord-345222-otfnrarh 571 16 patients patient NNS cord-345222-otfnrarh 571 17 , , , cord-345222-otfnrarh 571 18 particularly particularly RB cord-345222-otfnrarh 571 19 because because IN cord-345222-otfnrarh 571 20 of of IN cord-345222-otfnrarh 571 21 poor poor JJ cord-345222-otfnrarh 571 22 compliance compliance NN cord-345222-otfnrarh 571 23 , , , cord-345222-otfnrarh 571 24 antibiotic antibiotic JJ cord-345222-otfnrarh 571 25 resistance resistance NN cord-345222-otfnrarh 571 26 , , , cord-345222-otfnrarh 571 27 and and CC cord-345222-otfnrarh 571 28 occurrence occurrence NN cord-345222-otfnrarh 571 29 of of IN cord-345222-otfnrarh 571 30 side side NN cord-345222-otfnrarh 571 31 effects effect NNS cord-345222-otfnrarh 571 32 . . . cord-345222-otfnrarh 572 1 169 169 CD cord-345222-otfnrarh 572 2 Treatment treatment NN cord-345222-otfnrarh 572 3 regimens regimen NNS cord-345222-otfnrarh 572 4 generally generally RB cord-345222-otfnrarh 572 5 include include VBP cord-345222-otfnrarh 572 6 a a DT cord-345222-otfnrarh 572 7 proton proton NN cord-345222-otfnrarh 572 8 - - HYPH cord-345222-otfnrarh 572 9 pump pump NN cord-345222-otfnrarh 572 10 inhibitor inhibitor NN cord-345222-otfnrarh 572 11 ( ( -LRB- cord-345222-otfnrarh 572 12 lansoprazole lansoprazole NNP cord-345222-otfnrarh 572 13 , , , cord-345222-otfnrarh 572 14 omeprazole omeprazole NN cord-345222-otfnrarh 572 15 , , , cord-345222-otfnrarh 572 16 pantoprazole pantoprazole NNP cord-345222-otfnrarh 572 17 , , , cord-345222-otfnrarh 572 18 rabeprazole rabeprazole NNP cord-345222-otfnrarh 572 19 , , , cord-345222-otfnrarh 572 20 dexlansoprazole dexlansoprazole NNP cord-345222-otfnrarh 572 21 , , , cord-345222-otfnrarh 572 22 or or CC cord-345222-otfnrarh 572 23 esomeprazole esomeprazole NN cord-345222-otfnrarh 572 24 ) ) -RRB- cord-345222-otfnrarh 572 25 , , , cord-345222-otfnrarh 572 26 which which WDT cord-345222-otfnrarh 572 27 allows allow VBZ cord-345222-otfnrarh 572 28 the the DT cord-345222-otfnrarh 572 29 tissues tissue NNS cord-345222-otfnrarh 572 30 damaged damage VBN cord-345222-otfnrarh 572 31 by by IN cord-345222-otfnrarh 572 32 the the DT cord-345222-otfnrarh 572 33 infection infection NN cord-345222-otfnrarh 572 34 to to TO cord-345222-otfnrarh 572 35 heal heal VB cord-345222-otfnrarh 572 36 , , , cord-345222-otfnrarh 572 37 and and CC cord-345222-otfnrarh 572 38 two two CD cord-345222-otfnrarh 572 39 antibiotics antibiotic NNS cord-345222-otfnrarh 572 40 to to TO cord-345222-otfnrarh 572 41 reduce reduce VB cord-345222-otfnrarh 572 42 the the DT cord-345222-otfnrarh 572 43 risk risk NN cord-345222-otfnrarh 572 44 of of IN cord-345222-otfnrarh 572 45 treatment treatment NN cord-345222-otfnrarh 572 46 failure failure NN cord-345222-otfnrarh 572 47 and and CC cord-345222-otfnrarh 572 48 antibiotic antibiotic JJ cord-345222-otfnrarh 572 49 resistance resistance NN cord-345222-otfnrarh 572 50 . . . cord-345222-otfnrarh 573 1 Treatment treatment NN cord-345222-otfnrarh 573 2 requires require VBZ cord-345222-otfnrarh 573 3 several several JJ cord-345222-otfnrarh 573 4 medications medication NNS cord-345222-otfnrarh 573 5 for for IN cord-345222-otfnrarh 573 6 7 7 CD cord-345222-otfnrarh 573 7 - - SYM cord-345222-otfnrarh 573 8 14 14 CD cord-345222-otfnrarh 573 9 days day NNS cord-345222-otfnrarh 573 10 . . . cord-345222-otfnrarh 574 1 In in IN cord-345222-otfnrarh 574 2 pediatric pediatric JJ cord-345222-otfnrarh 574 3 patients patient NNS cord-345222-otfnrarh 574 4 , , , cord-345222-otfnrarh 574 5 gastric gastric JJ cord-345222-otfnrarh 574 6 mucosal mucosal JJ cord-345222-otfnrarh 574 7 lesion lesion NN cord-345222-otfnrarh 574 8 - - HYPH cord-345222-otfnrarh 574 9 caused cause VBN cord-345222-otfnrarh 574 10 H. h. NN cord-345222-otfnrarh 574 11 pylori pylori NN cord-345222-otfnrarh 574 12 infection infection NN cord-345222-otfnrarh 574 13 is be VBZ cord-345222-otfnrarh 574 14 a a DT cord-345222-otfnrarh 574 15 reversible reversible JJ cord-345222-otfnrarh 574 16 process process NN cord-345222-otfnrarh 574 17 , , , cord-345222-otfnrarh 574 18 and and CC cord-345222-otfnrarh 574 19 the the DT cord-345222-otfnrarh 574 20 eradication eradication NN cord-345222-otfnrarh 574 21 of of IN cord-345222-otfnrarh 574 22 this this DT cord-345222-otfnrarh 574 23 infection infection NN cord-345222-otfnrarh 574 24 not not RB cord-345222-otfnrarh 574 25 only only RB cord-345222-otfnrarh 574 26 stops stop VBZ cord-345222-otfnrarh 574 27 the the DT cord-345222-otfnrarh 574 28 activity activity NN cord-345222-otfnrarh 574 29 of of IN cord-345222-otfnrarh 574 30 the the DT cord-345222-otfnrarh 574 31 inflammatory inflammatory JJ cord-345222-otfnrarh 574 32 process process NN cord-345222-otfnrarh 574 33 but but CC cord-345222-otfnrarh 574 34 also also RB cord-345222-otfnrarh 574 35 restores restore VBZ cord-345222-otfnrarh 574 36 the the DT cord-345222-otfnrarh 574 37 mucous mucous JJ cord-345222-otfnrarh 574 38 membranes membrane NNS cord-345222-otfnrarh 574 39 , , , cord-345222-otfnrarh 574 40 reduces reduce VBZ cord-345222-otfnrarh 574 41 the the DT cord-345222-otfnrarh 574 42 incidence incidence NN cord-345222-otfnrarh 574 43 of of IN cord-345222-otfnrarh 574 44 recurrence recurrence NN cord-345222-otfnrarh 574 45 of of IN cord-345222-otfnrarh 574 46 gastritis gastritis NN cord-345222-otfnrarh 574 47 and and CC cord-345222-otfnrarh 574 48 peptic peptic JJ cord-345222-otfnrarh 574 49 ulcer ulcer NN cord-345222-otfnrarh 574 50 disease disease NN cord-345222-otfnrarh 574 51 , , , cord-345222-otfnrarh 574 52 and and CC cord-345222-otfnrarh 574 53 can can MD cord-345222-otfnrarh 574 54 lead lead VB cord-345222-otfnrarh 574 55 to to IN cord-345222-otfnrarh 574 56 prevention prevention NN cord-345222-otfnrarh 574 57 of of IN cord-345222-otfnrarh 574 58 malignant malignant JJ cord-345222-otfnrarh 574 59 disease disease NN cord-345222-otfnrarh 574 60 in in IN cord-345222-otfnrarh 574 61 70%-80 70%-80 CD cord-345222-otfnrarh 574 62 % % NN cord-345222-otfnrarh 574 63 of of IN cord-345222-otfnrarh 574 64 cases case NNS cord-345222-otfnrarh 574 65 . . . cord-345222-otfnrarh 575 1 170 170 CD cord-345222-otfnrarh 575 2 Adjuvant Adjuvant NNP cord-345222-otfnrarh 575 3 therapy therapy NN cord-345222-otfnrarh 575 4 with with IN cord-345222-otfnrarh 575 5 probiotics probiotic NNS cord-345222-otfnrarh 575 6 has have VBZ cord-345222-otfnrarh 575 7 been be VBN cord-345222-otfnrarh 575 8 studied study VBN cord-345222-otfnrarh 575 9 in in IN cord-345222-otfnrarh 575 10 recent recent JJ cord-345222-otfnrarh 575 11 years year NNS cord-345222-otfnrarh 575 12 . . . cord-345222-otfnrarh 576 1 169 169 CD cord-345222-otfnrarh 577 1 In in IN cord-345222-otfnrarh 577 2 a a DT cord-345222-otfnrarh 577 3 recent recent JJ cord-345222-otfnrarh 577 4 randomized randomized JJ cord-345222-otfnrarh 577 5 , , , cord-345222-otfnrarh 577 6 placebo placebo NN cord-345222-otfnrarh 577 7 - - HYPH cord-345222-otfnrarh 577 8 controlled control VBN cord-345222-otfnrarh 577 9 , , , cord-345222-otfnrarh 577 10 double double JJ cord-345222-otfnrarh 577 11 - - HYPH cord-345222-otfnrarh 577 12 blind blind JJ cord-345222-otfnrarh 577 13 study study NN cord-345222-otfnrarh 577 14 , , , cord-345222-otfnrarh 577 15 children child NNS cord-345222-otfnrarh 577 16 on on IN cord-345222-otfnrarh 577 17 H. H. NNP cord-345222-otfnrarh 577 18 pylori pylori NN cord-345222-otfnrarh 577 19 eradication eradication NN cord-345222-otfnrarh 577 20 therapy therapy NN cord-345222-otfnrarh 577 21 receiving receive VBG cord-345222-otfnrarh 577 22 seven seven CD cord-345222-otfnrarh 577 23 strains strain NNS cord-345222-otfnrarh 577 24 of of IN cord-345222-otfnrarh 577 25 probiotic probiotic NN cord-345222-otfnrarh 577 26 in in IN cord-345222-otfnrarh 577 27 addition addition NN cord-345222-otfnrarh 577 28 to to IN cord-345222-otfnrarh 577 29 the the DT cord-345222-otfnrarh 577 30 standard standard JJ cord-345222-otfnrarh 577 31 triple triple JJ cord-345222-otfnrarh 577 32 regimen regimen NN cord-345222-otfnrarh 577 33 ( ( -LRB- cord-345222-otfnrarh 577 34 omeprazole omeprazole NNP cord-345222-otfnrarh 577 35 + + CC cord-345222-otfnrarh 577 36 amoxicillin amoxicillin NNP cord-345222-otfnrarh 577 37 + + SYM cord-345222-otfnrarh 577 38 claritromicin claritromicin NNP cord-345222-otfnrarh 577 39 or or CC cord-345222-otfnrarh 577 40 omeprazole omeprazole NN cord-345222-otfnrarh 577 41 + + CC cord-345222-otfnrarh 577 42 amoxycillin amoxycillin NN cord-345222-otfnrarh 577 43 + + CC cord-345222-otfnrarh 577 44 furazolidon furazolidon NNP cord-345222-otfnrarh 577 45 ) ) -RRB- cord-345222-otfnrarh 577 46 were be VBD cord-345222-otfnrarh 577 47 compared compare VBN cord-345222-otfnrarh 577 48 with with IN cord-345222-otfnrarh 577 49 patients patient NNS cord-345222-otfnrarh 577 50 on on IN cord-345222-otfnrarh 577 51 the the DT cord-345222-otfnrarh 577 52 same same JJ cord-345222-otfnrarh 577 53 triple triple JJ cord-345222-otfnrarh 577 54 regimen regimen NN cord-345222-otfnrarh 577 55 receiving receive VBG cord-345222-otfnrarh 577 56 placebo placebo NN cord-345222-otfnrarh 577 57 . . . cord-345222-otfnrarh 578 1 The the DT cord-345222-otfnrarh 578 2 findings finding NNS cord-345222-otfnrarh 578 3 reported report VBD cord-345222-otfnrarh 578 4 a a DT cord-345222-otfnrarh 578 5 significant significant JJ cord-345222-otfnrarh 578 6 reduction reduction NN cord-345222-otfnrarh 578 7 in in IN cord-345222-otfnrarh 578 8 treatment treatment NN cord-345222-otfnrarh 578 9 complications complication NNS cord-345222-otfnrarh 578 10 and and CC cord-345222-otfnrarh 578 11 an an DT cord-345222-otfnrarh 578 12 improved improved JJ cord-345222-otfnrarh 578 13 therapeutic therapeutic JJ cord-345222-otfnrarh 578 14 outcome outcome NN cord-345222-otfnrarh 578 15 : : : cord-345222-otfnrarh 578 16 the the DT cord-345222-otfnrarh 578 17 rate rate NN cord-345222-otfnrarh 578 18 of of IN cord-345222-otfnrarh 578 19 eradication eradication NN cord-345222-otfnrarh 578 20 was be VBD cord-345222-otfnrarh 578 21 significantly significantly RB cord-345222-otfnrarh 578 22 higher high JJR cord-345222-otfnrarh 578 23 , , , cord-345222-otfnrarh 578 24 and and CC cord-345222-otfnrarh 578 25 children child NNS cord-345222-otfnrarh 578 26 had have VBD cord-345222-otfnrarh 578 27 a a DT cord-345222-otfnrarh 578 28 lower low JJR cord-345222-otfnrarh 578 29 rate rate NN cord-345222-otfnrarh 578 30 of of IN cord-345222-otfnrarh 578 31 nausea nausea NN cord-345222-otfnrarh 578 32 / / SYM cord-345222-otfnrarh 578 33 vomiting vomiting NN cord-345222-otfnrarh 578 34 and and CC cord-345222-otfnrarh 578 35 diarrhea diarrhea NN cord-345222-otfnrarh 578 36 during during IN cord-345222-otfnrarh 578 37 treatment treatment NN cord-345222-otfnrarh 578 38 . . . cord-345222-otfnrarh 579 1 168 168 CD cord-345222-otfnrarh 580 1 The the DT cord-345222-otfnrarh 580 2 long long JJ cord-345222-otfnrarh 580 3 - - HYPH cord-345222-otfnrarh 580 4 term term NN cord-345222-otfnrarh 580 5 success success NN cord-345222-otfnrarh 580 6 of of IN cord-345222-otfnrarh 580 7 H. h. NN cord-345222-otfnrarh 580 8 pylori pylori NN cord-345222-otfnrarh 580 9 eradication eradication NN cord-345222-otfnrarh 580 10 interventions intervention NNS cord-345222-otfnrarh 580 11 for for IN cord-345222-otfnrarh 580 12 preventing prevent VBG cord-345222-otfnrarh 580 13 gastric gastric JJ cord-345222-otfnrarh 580 14 cancer cancer NN cord-345222-otfnrarh 580 15 , , , cord-345222-otfnrarh 580 16 depends depend VBZ cord-345222-otfnrarh 580 17 on on IN cord-345222-otfnrarh 580 18 the the DT cord-345222-otfnrarh 580 19 recurrence recurrence NN cord-345222-otfnrarh 580 20 determinants determinant NNS cord-345222-otfnrarh 580 21 ( ( -LRB- cord-345222-otfnrarh 580 22 nonadherence nonadherence NNP cord-345222-otfnrarh 580 23 and and CC cord-345222-otfnrarh 580 24 demographics demographic NNS cord-345222-otfnrarh 580 25 ) ) -RRB- cord-345222-otfnrarh 580 26 that that WDT cord-345222-otfnrarh 580 27 are be VBP cord-345222-otfnrarh 580 28 as as RB cord-345222-otfnrarh 580 29 important important JJ cord-345222-otfnrarh 580 30 as as IN cord-345222-otfnrarh 580 31 a a DT cord-345222-otfnrarh 580 32 specific specific JJ cord-345222-otfnrarh 580 33 antibiotic antibiotic JJ cord-345222-otfnrarh 580 34 regimen regimen NN cord-345222-otfnrarh 580 35 . . . cord-345222-otfnrarh 581 1 171 171 CD cord-345222-otfnrarh 582 1 Despite despite IN cord-345222-otfnrarh 582 2 Plesiomonas Plesiomonas NNP cord-345222-otfnrarh 582 3 shigelloides shigelloide NNS cord-345222-otfnrarh 582 4 seeming seem VBG cord-345222-otfnrarh 582 5 to to TO cord-345222-otfnrarh 582 6 be be VB cord-345222-otfnrarh 582 7 a a DT cord-345222-otfnrarh 582 8 minor minor JJ cord-345222-otfnrarh 582 9 cause cause NN cord-345222-otfnrarh 582 10 of of IN cord-345222-otfnrarh 582 11 bacterial bacterial JJ cord-345222-otfnrarh 582 12 enteritis enteritis NN cord-345222-otfnrarh 582 13 , , , cord-345222-otfnrarh 582 14 the the DT cord-345222-otfnrarh 582 15 pathogen pathogen NN cord-345222-otfnrarh 582 16 has have VBZ cord-345222-otfnrarh 582 17 been be VBN cord-345222-otfnrarh 582 18 implicated implicate VBN cord-345222-otfnrarh 582 19 in in IN cord-345222-otfnrarh 582 20 gastroenteritis gastroenteritis JJ cord-345222-otfnrarh 582 21 outbreaks outbreak NNS cord-345222-otfnrarh 582 22 in in IN cord-345222-otfnrarh 582 23 tropical tropical JJ cord-345222-otfnrarh 582 24 regions region NNS cord-345222-otfnrarh 582 25 and and CC cord-345222-otfnrarh 582 26 in in IN cord-345222-otfnrarh 582 27 cases case NNS cord-345222-otfnrarh 582 28 of of IN cord-345222-otfnrarh 582 29 traveler traveler NN cord-345222-otfnrarh 582 30 's 's POS cord-345222-otfnrarh 582 31 diarrhea diarrhea NN cord-345222-otfnrarh 582 32 . . . cord-345222-otfnrarh 583 1 Antibacterials antibacterial NNS cord-345222-otfnrarh 583 2 are be VBP cord-345222-otfnrarh 583 3 used use VBN cord-345222-otfnrarh 583 4 only only RB cord-345222-otfnrarh 583 5 in in IN cord-345222-otfnrarh 583 6 cases case NNS cord-345222-otfnrarh 583 7 of of IN cord-345222-otfnrarh 583 8 severe severe JJ cord-345222-otfnrarh 583 9 and and CC cord-345222-otfnrarh 583 10 unresponsive unresponsive JJ cord-345222-otfnrarh 583 11 infections infection NNS cord-345222-otfnrarh 583 12 : : : cord-345222-otfnrarh 583 13 the the DT cord-345222-otfnrarh 583 14 most most RBS cord-345222-otfnrarh 583 15 effective effective JJ cord-345222-otfnrarh 583 16 are be VBP cord-345222-otfnrarh 583 17 ciprofloxacin ciprofloxacin NN cord-345222-otfnrarh 583 18 and and CC cord-345222-otfnrarh 583 19 azythromycin azythromycin NNS cord-345222-otfnrarh 583 20 , , , cord-345222-otfnrarh 583 21 and and CC cord-345222-otfnrarh 583 22 partially partially RB cord-345222-otfnrarh 583 23 trimethoprimsulfamethoxazole trimethoprimsulfamethoxazole NNP cord-345222-otfnrarh 583 24 . . . cord-345222-otfnrarh 584 1 With with IN cord-345222-otfnrarh 584 2 Salmonella Salmonella NNP cord-345222-otfnrarh 584 3 spp spp NNS cord-345222-otfnrarh 584 4 , , , cord-345222-otfnrarh 584 5 antibiotics antibiotic NNS cord-345222-otfnrarh 584 6 are be VBP cord-345222-otfnrarh 584 7 initiated initiate VBN cord-345222-otfnrarh 584 8 in in IN cord-345222-otfnrarh 584 9 cases case NNS cord-345222-otfnrarh 584 10 of of IN cord-345222-otfnrarh 584 11 febrile febrile JJ cord-345222-otfnrarh 584 12 diarrhea diarrhea NN cord-345222-otfnrarh 584 13 , , , cord-345222-otfnrarh 584 14 especially especially RB cord-345222-otfnrarh 584 15 in in IN cord-345222-otfnrarh 584 16 case case NN cord-345222-otfnrarh 584 17 of of IN cord-345222-otfnrarh 584 18 moderate moderate JJ cord-345222-otfnrarh 584 19 to to IN cord-345222-otfnrarh 584 20 severe severe JJ cord-345222-otfnrarh 584 21 disease disease NN cord-345222-otfnrarh 584 22 . . . cord-345222-otfnrarh 585 1 The the DT cord-345222-otfnrarh 585 2 administration administration NN cord-345222-otfnrarh 585 3 of of IN cord-345222-otfnrarh 585 4 azithromycin azithromycin NNP cord-345222-otfnrarh 585 5 empirically empirically RB cord-345222-otfnrarh 585 6 for for IN cord-345222-otfnrarh 585 7 acute acute JJ cord-345222-otfnrarh 585 8 diarrhea diarrhea NN cord-345222-otfnrarh 585 9 , , , cord-345222-otfnrarh 585 10 when when WRB cord-345222-otfnrarh 585 11 indicated indicate VBN cord-345222-otfnrarh 585 12 , , , cord-345222-otfnrarh 585 13 could could MD cord-345222-otfnrarh 585 14 be be VB cord-345222-otfnrarh 585 15 appropriate appropriate JJ cord-345222-otfnrarh 585 16 . . . cord-345222-otfnrarh 586 1 4 4 CD cord-345222-otfnrarh 586 2 , , , cord-345222-otfnrarh 586 3 153 153 CD cord-345222-otfnrarh 587 1 Consistent consistent JJ cord-345222-otfnrarh 587 2 evidence evidence NN cord-345222-otfnrarh 587 3 from from IN cord-345222-otfnrarh 587 4 several several JJ cord-345222-otfnrarh 587 5 clinical clinical JJ cord-345222-otfnrarh 587 6 trials trial NNS cord-345222-otfnrarh 587 7 suggests suggest VBZ cord-345222-otfnrarh 587 8 that that IN cord-345222-otfnrarh 587 9 antibiotic antibiotic JJ cord-345222-otfnrarh 587 10 treatment treatment NN cord-345222-otfnrarh 587 11 ( ( -LRB- cord-345222-otfnrarh 587 12 ampicillin ampicillin NNP cord-345222-otfnrarh 587 13 , , , cord-345222-otfnrarh 587 14 amoxicillin amoxicillin NNP cord-345222-otfnrarh 587 15 , , , cord-345222-otfnrarh 587 16 cefixime cefixime NNP cord-345222-otfnrarh 587 17 , , , cord-345222-otfnrarh 587 18 azithromycin azithromycin NNP cord-345222-otfnrarh 587 19 , , , cord-345222-otfnrarh 587 20 cotrimoxazole cotrimoxazole NNP cord-345222-otfnrarh 587 21 ) ) -RRB- cord-345222-otfnrarh 587 22 did do VBD cord-345222-otfnrarh 587 23 not not RB cord-345222-otfnrarh 587 24 shorten shorten VB cord-345222-otfnrarh 587 25 the the DT cord-345222-otfnrarh 587 26 duration duration NN cord-345222-otfnrarh 587 27 of of IN cord-345222-otfnrarh 587 28 diarrhea diarrhea NN cord-345222-otfnrarh 587 29 or or CC cord-345222-otfnrarh 587 30 lead lead VB cord-345222-otfnrarh 587 31 to to IN cord-345222-otfnrarh 587 32 an an DT cord-345222-otfnrarh 587 33 earlier early JJR cord-345222-otfnrarh 587 34 resolution resolution NN cord-345222-otfnrarh 587 35 of of IN cord-345222-otfnrarh 587 36 clinical clinical JJ cord-345222-otfnrarh 587 37 symptoms symptom NNS cord-345222-otfnrarh 587 38 . . . cord-345222-otfnrarh 588 1 Intramuscular intramuscular JJ cord-345222-otfnrarh 588 2 ampicillin ampicillin NN cord-345222-otfnrarh 588 3 protects protect VBZ cord-345222-otfnrarh 588 4 children child NNS cord-345222-otfnrarh 588 5 against against IN cord-345222-otfnrarh 588 6 relapse relapse NN cord-345222-otfnrarh 588 7 and and CC cord-345222-otfnrarh 588 8 reduces reduce VBZ cord-345222-otfnrarh 588 9 the the DT cord-345222-otfnrarh 588 10 carriage carriage NN cord-345222-otfnrarh 588 11 of of IN cord-345222-otfnrarh 588 12 Salmonella Salmonella NNP cord-345222-otfnrarh 588 13 infection infection NN cord-345222-otfnrarh 588 14 significantly significantly RB cord-345222-otfnrarh 588 15 better well JJR cord-345222-otfnrarh 588 16 than than IN cord-345222-otfnrarh 588 17 placebo placebo NN cord-345222-otfnrarh 588 18 , , , cord-345222-otfnrarh 588 19 oral oral JJ cord-345222-otfnrarh 588 20 ampicillin ampicillin NN cord-345222-otfnrarh 588 21 , , , cord-345222-otfnrarh 588 22 or or CC cord-345222-otfnrarh 588 23 amoxicillin amoxicillin NNP cord-345222-otfnrarh 588 24 . . . cord-345222-otfnrarh 589 1 4 4 LS cord-345222-otfnrarh 589 2 Antibiotics antibiotic NNS cord-345222-otfnrarh 589 3 are be VBP cord-345222-otfnrarh 589 4 usually usually RB cord-345222-otfnrarh 589 5 avoided avoid VBN cord-345222-otfnrarh 589 6 in in IN cord-345222-otfnrarh 589 7 mild mild JJ cord-345222-otfnrarh 589 8 Shigella Shigella NNP cord-345222-otfnrarh 589 9 illness illness NN cord-345222-otfnrarh 589 10 , , , cord-345222-otfnrarh 589 11 because because IN cord-345222-otfnrarh 589 12 mild mild JJ cord-345222-otfnrarh 589 13 forms form NNS cord-345222-otfnrarh 589 14 of of IN cord-345222-otfnrarh 589 15 Shigella Shigella NNP cord-345222-otfnrarh 589 16 dysentery dysentery NN cord-345222-otfnrarh 589 17 are be VBP cord-345222-otfnrarh 589 18 said say VBN cord-345222-otfnrarh 589 19 to to TO cord-345222-otfnrarh 589 20 be be VB cord-345222-otfnrarh 589 21 self self NN cord-345222-otfnrarh 589 22 limiting limit VBG cord-345222-otfnrarh 589 23 , , , cord-345222-otfnrarh 589 24 some some DT cord-345222-otfnrarh 589 25 Shigella Shigella NNP cord-345222-otfnrarh 589 26 strains strain NNS cord-345222-otfnrarh 589 27 are be VBP cord-345222-otfnrarh 589 28 resistant resistant JJ cord-345222-otfnrarh 589 29 to to IN cord-345222-otfnrarh 589 30 antibiotics antibiotic NNS cord-345222-otfnrarh 589 31 , , , cord-345222-otfnrarh 589 32 and and CC cord-345222-otfnrarh 589 33 their -PRON- PRP$ cord-345222-otfnrarh 589 34 use use NN cord-345222-otfnrarh 589 35 may may MD cord-345222-otfnrarh 589 36 lead lead VB cord-345222-otfnrarh 589 37 to to IN cord-345222-otfnrarh 589 38 increased increase VBN cord-345222-otfnrarh 589 39 resistance resistance NN cord-345222-otfnrarh 589 40 . . . cord-345222-otfnrarh 590 1 If if IN cord-345222-otfnrarh 590 2 necessary necessary JJ cord-345222-otfnrarh 590 3 , , , cord-345222-otfnrarh 590 4 in in IN cord-345222-otfnrarh 590 5 severe severe JJ cord-345222-otfnrarh 590 6 cases case NNS cord-345222-otfnrarh 590 7 , , , cord-345222-otfnrarh 590 8 the the DT cord-345222-otfnrarh 590 9 choice choice NN cord-345222-otfnrarh 590 10 of of IN cord-345222-otfnrarh 590 11 antibiotic antibiotic NN cord-345222-otfnrarh 590 12 to to TO cord-345222-otfnrarh 590 13 use use VB cord-345222-otfnrarh 590 14 as as IN cord-345222-otfnrarh 590 15 first first JJ cord-345222-otfnrarh 590 16 line line NN cord-345222-otfnrarh 590 17 against against IN cord-345222-otfnrarh 590 18 Shigella Shigella NNP cord-345222-otfnrarh 590 19 dysentery dysentery NN cord-345222-otfnrarh 590 20 should should MD cord-345222-otfnrarh 590 21 be be VB cord-345222-otfnrarh 590 22 governed govern VBN cord-345222-otfnrarh 590 23 by by IN cord-345222-otfnrarh 590 24 periodically periodically RB cord-345222-otfnrarh 590 25 updated update VBN cord-345222-otfnrarh 590 26 local local JJ cord-345222-otfnrarh 590 27 antibiotic antibiotic JJ cord-345222-otfnrarh 590 28 sensitivity sensitivity NN cord-345222-otfnrarh 590 29 patterns pattern NNS cord-345222-otfnrarh 590 30 of of IN cord-345222-otfnrarh 590 31 Shigella Shigella NNP cord-345222-otfnrarh 590 32 isolates isolate NNS cord-345222-otfnrarh 590 33 . . . cord-345222-otfnrarh 591 1 Other other JJ cord-345222-otfnrarh 591 2 supportive supportive JJ cord-345222-otfnrarh 591 3 and and CC cord-345222-otfnrarh 591 4 preventive preventive JJ cord-345222-otfnrarh 591 5 measures measure NNS cord-345222-otfnrarh 591 6 recommended recommend VBN cord-345222-otfnrarh 591 7 by by IN cord-345222-otfnrarh 591 8 the the DT cord-345222-otfnrarh 591 9 WHO who WP cord-345222-otfnrarh 591 10 should should MD cord-345222-otfnrarh 591 11 also also RB cord-345222-otfnrarh 591 12 be be VB cord-345222-otfnrarh 591 13 instituted institute VBN cord-345222-otfnrarh 591 14 along along IN cord-345222-otfnrarh 591 15 with with IN cord-345222-otfnrarh 591 16 antibiotics antibiotic NNS cord-345222-otfnrarh 591 17 ( ( -LRB- cord-345222-otfnrarh 591 18 eg eg UH cord-345222-otfnrarh 591 19 , , , cord-345222-otfnrarh 591 20 health health NN cord-345222-otfnrarh 591 21 education education NN cord-345222-otfnrarh 591 22 and and CC cord-345222-otfnrarh 591 23 hand hand NN cord-345222-otfnrarh 591 24 - - HYPH cord-345222-otfnrarh 591 25 washing washing NN cord-345222-otfnrarh 591 26 ) ) -RRB- cord-345222-otfnrarh 591 27 . . . cord-345222-otfnrarh 592 1 Ciprofloxacin Ciprofloxacin NNP cord-345222-otfnrarh 592 2 has have VBZ cord-345222-otfnrarh 592 3 been be VBN cord-345222-otfnrarh 592 4 recommended recommend VBN cord-345222-otfnrarh 592 5 by by IN cord-345222-otfnrarh 592 6 the the DT cord-345222-otfnrarh 592 7 WHO WHO NNP cord-345222-otfnrarh 592 8 as as IN cord-345222-otfnrarh 592 9 the the DT cord-345222-otfnrarh 592 10 drug drug NN cord-345222-otfnrarh 592 11 of of IN cord-345222-otfnrarh 592 12 choice choice NN cord-345222-otfnrarh 592 13 for for IN cord-345222-otfnrarh 592 14 all all DT cord-345222-otfnrarh 592 15 patients patient NNS cord-345222-otfnrarh 592 16 with with IN cord-345222-otfnrarh 592 17 bloody bloody JJ cord-345222-otfnrarh 592 18 diarrhea diarrhea NN cord-345222-otfnrarh 592 19 , , , cord-345222-otfnrarh 592 20 irrespective irrespective RB cord-345222-otfnrarh 592 21 of of IN cord-345222-otfnrarh 592 22 their -PRON- PRP$ cord-345222-otfnrarh 592 23 ages age NNS cord-345222-otfnrarh 592 24 . . . cord-345222-otfnrarh 593 1 172 172 CD cord-345222-otfnrarh 594 1 According accord VBG cord-345222-otfnrarh 594 2 to to IN cord-345222-otfnrarh 594 3 a a DT cord-345222-otfnrarh 594 4 recent recent JJ cord-345222-otfnrarh 594 5 Cochrane Cochrane NNP cord-345222-otfnrarh 594 6 review review NN cord-345222-otfnrarh 594 7 , , , cord-345222-otfnrarh 594 8 the the DT cord-345222-otfnrarh 594 9 authors author NNS cord-345222-otfnrarh 594 10 did do VBD cord-345222-otfnrarh 594 11 not not RB cord-345222-otfnrarh 594 12 find find VB cord-345222-otfnrarh 594 13 robust robust JJ cord-345222-otfnrarh 594 14 evidence evidence NN cord-345222-otfnrarh 594 15 to to TO cord-345222-otfnrarh 594 16 suggest suggest VB cord-345222-otfnrarh 594 17 that that IN cord-345222-otfnrarh 594 18 antibiotics antibiotic NNS cord-345222-otfnrarh 594 19 of of IN cord-345222-otfnrarh 594 20 a a DT cord-345222-otfnrarh 594 21 particular particular JJ cord-345222-otfnrarh 594 22 class class NN cord-345222-otfnrarh 594 23 are be VBP cord-345222-otfnrarh 594 24 better well JJR cord-345222-otfnrarh 594 25 than than IN cord-345222-otfnrarh 594 26 those those DT cord-345222-otfnrarh 594 27 belonging belong VBG cord-345222-otfnrarh 594 28 to to IN cord-345222-otfnrarh 594 29 a a DT cord-345222-otfnrarh 594 30 different different JJ cord-345222-otfnrarh 594 31 class class NN cord-345222-otfnrarh 594 32 . . . cord-345222-otfnrarh 595 1 Trials trial NNS cord-345222-otfnrarh 595 2 report report VBP cord-345222-otfnrarh 595 3 that that IN cord-345222-otfnrarh 595 4 at at IN cord-345222-otfnrarh 595 5 various various JJ cord-345222-otfnrarh 595 6 periods period NNS cord-345222-otfnrarh 595 7 of of IN cord-345222-otfnrarh 595 8 time time NN cord-345222-otfnrarh 595 9 , , , cord-345222-otfnrarh 595 10 different different JJ cord-345222-otfnrarh 595 11 antibiotics antibiotic NNS cord-345222-otfnrarh 595 12 have have VBP cord-345222-otfnrarh 595 13 been be VBN cord-345222-otfnrarh 595 14 effective effective JJ cord-345222-otfnrarh 595 15 against against IN cord-345222-otfnrarh 595 16 isolates isolate NNS cord-345222-otfnrarh 595 17 of of IN cord-345222-otfnrarh 595 18 Shigella Shigella NNP cord-345222-otfnrarh 595 19 dysentery dysentery NN cord-345222-otfnrarh 595 20 in in IN cord-345222-otfnrarh 595 21 different different JJ cord-345222-otfnrarh 595 22 parts part NNS cord-345222-otfnrarh 595 23 of of IN cord-345222-otfnrarh 595 24 the the DT cord-345222-otfnrarh 595 25 world world NN cord-345222-otfnrarh 595 26 . . . cord-345222-otfnrarh 596 1 These these DT cord-345222-otfnrarh 596 2 are be VBP cord-345222-otfnrarh 596 3 ampicillin ampicillin NN cord-345222-otfnrarh 596 4 , , , cord-345222-otfnrarh 596 5 cotrimoxazole cotrimoxazole NNP cord-345222-otfnrarh 596 6 , , , cord-345222-otfnrarh 596 7 nalidixic nalidixic RB cord-345222-otfnrarh 596 8 acid acid NN cord-345222-otfnrarh 596 9 , , , cord-345222-otfnrarh 596 10 fluoroquinolones fluoroquinolone NNS cord-345222-otfnrarh 596 11 submit submit VBP cord-345222-otfnrarh 596 12 your -PRON- PRP$ cord-345222-otfnrarh 596 13 manuscript manuscript NN cord-345222-otfnrarh 596 14 | | POS cord-345222-otfnrarh 596 15 www.dovepress.com www.dovepress.com ADD cord-345222-otfnrarh 597 1 Dovepress Dovepress NNP cord-345222-otfnrarh 597 2 Dovepress Dovepress NNP cord-345222-otfnrarh 597 3 like like IN cord-345222-otfnrarh 597 4 ciprofloxacin ciprofloxacin NN cord-345222-otfnrarh 597 5 , , , cord-345222-otfnrarh 597 6 pivmecillinam pivmecillinam NNP cord-345222-otfnrarh 597 7 , , , cord-345222-otfnrarh 597 8 ceftriaxone ceftriaxone NN cord-345222-otfnrarh 597 9 , , , cord-345222-otfnrarh 597 10 and and CC cord-345222-otfnrarh 597 11 azithromycin azithromycin NN cord-345222-otfnrarh 597 12 . . . cord-345222-otfnrarh 598 1 However however RB cord-345222-otfnrarh 598 2 , , , cord-345222-otfnrarh 598 3 limited limited JJ cord-345222-otfnrarh 598 4 data datum NNS cord-345222-otfnrarh 598 5 from from IN cord-345222-otfnrarh 598 6 a a DT cord-345222-otfnrarh 598 7 subgroup subgroup NN cord-345222-otfnrarh 598 8 of of IN cord-345222-otfnrarh 598 9 studies study NNS cord-345222-otfnrarh 598 10 suggest suggest VBP cord-345222-otfnrarh 598 11 that that IN cord-345222-otfnrarh 598 12 a a DT cord-345222-otfnrarh 598 13 fluoroquinolone fluoroquinolone NN cord-345222-otfnrarh 598 14 ( ( -LRB- cord-345222-otfnrarh 598 15 ciprofloxacin ciprofloxacin NN cord-345222-otfnrarh 598 16 ) ) -RRB- cord-345222-otfnrarh 598 17 would would MD cord-345222-otfnrarh 598 18 be be VB cord-345222-otfnrarh 598 19 more more RBR cord-345222-otfnrarh 598 20 effective effective JJ cord-345222-otfnrarh 598 21 than than IN cord-345222-otfnrarh 598 22 a a DT cord-345222-otfnrarh 598 23 beta beta NN cord-345222-otfnrarh 598 24 - - HYPH cord-345222-otfnrarh 598 25 lactam lactam NN cord-345222-otfnrarh 598 26 ( ( -LRB- cord-345222-otfnrarh 598 27 ampicillin ampicillin NN cord-345222-otfnrarh 598 28 ) ) -RRB- cord-345222-otfnrarh 598 29 in in IN cord-345222-otfnrarh 598 30 reducing reduce VBG cord-345222-otfnrarh 598 31 diarrhea diarrhea NN cord-345222-otfnrarh 598 32 among among IN cord-345222-otfnrarh 598 33 adults adult NNS cord-345222-otfnrarh 598 34 , , , cord-345222-otfnrarh 598 35 and and CC cord-345222-otfnrarh 598 36 that that IN cord-345222-otfnrarh 598 37 beta beta NN cord-345222-otfnrarh 598 38 - - HYPH cord-345222-otfnrarh 598 39 lactams lactam NNS cord-345222-otfnrarh 598 40 would would MD cord-345222-otfnrarh 598 41 be be VB cord-345222-otfnrarh 598 42 more more RBR cord-345222-otfnrarh 598 43 effective effective JJ cord-345222-otfnrarh 598 44 than than IN cord-345222-otfnrarh 598 45 fluoroquinolones fluoroquinolone NNS cord-345222-otfnrarh 598 46 in in IN cord-345222-otfnrarh 598 47 reducing reduce VBG cord-345222-otfnrarh 598 48 diarrhea diarrhea NN cord-345222-otfnrarh 598 49 among among IN cord-345222-otfnrarh 598 50 children child NNS cord-345222-otfnrarh 598 51 with with IN cord-345222-otfnrarh 598 52 proven prove VBN cord-345222-otfnrarh 598 53 Shigella Shigella NNP cord-345222-otfnrarh 598 54 dysentery dysentery NN cord-345222-otfnrarh 598 55 . . . cord-345222-otfnrarh 599 1 Emerging emerge VBG cord-345222-otfnrarh 599 2 drug drug NN cord-345222-otfnrarh 599 3 resistance resistance NN cord-345222-otfnrarh 599 4 to to IN cord-345222-otfnrarh 599 5 ciprofloxacin ciprofloxacin NN cord-345222-otfnrarh 599 6 and and CC cord-345222-otfnrarh 599 7 second second JJ cord-345222-otfnrarh 599 8 - - HYPH cord-345222-otfnrarh 599 9 line line NN cord-345222-otfnrarh 599 10 drugs drug NNS cord-345222-otfnrarh 599 11 such such JJ cord-345222-otfnrarh 599 12 as as IN cord-345222-otfnrarh 599 13 pivmecillinam pivmecillinam NNP cord-345222-otfnrarh 599 14 , , , cord-345222-otfnrarh 599 15 ceftriaxone ceftriaxone NN cord-345222-otfnrarh 599 16 , , , cord-345222-otfnrarh 599 17 and and CC cord-345222-otfnrarh 599 18 azithromycin azithromycin NN cord-345222-otfnrarh 599 19 is be VBZ cord-345222-otfnrarh 599 20 increasingly increasingly RB cord-345222-otfnrarh 599 21 being be VBG cord-345222-otfnrarh 599 22 reported report VBN cord-345222-otfnrarh 599 23 in in IN cord-345222-otfnrarh 599 24 many many JJ cord-345222-otfnrarh 599 25 parts part NNS cord-345222-otfnrarh 599 26 of of IN cord-345222-otfnrarh 599 27 the the DT cord-345222-otfnrarh 599 28 world world NN cord-345222-otfnrarh 599 29 , , , cord-345222-otfnrarh 599 30 as as IN cord-345222-otfnrarh 599 31 is be VBZ cord-345222-otfnrarh 599 32 multiple multiple JJ cord-345222-otfnrarh 599 33 - - HYPH cord-345222-otfnrarh 599 34 drug drug NN cord-345222-otfnrarh 599 35 resistance resistance NN cord-345222-otfnrarh 599 36 . . . cord-345222-otfnrarh 600 1 173 173 CD cord-345222-otfnrarh 600 2 , , , cord-345222-otfnrarh 600 3 174 174 CD cord-345222-otfnrarh 601 1 In in IN cord-345222-otfnrarh 601 2 India India NNP cord-345222-otfnrarh 601 3 , , , cord-345222-otfnrarh 601 4 for for IN cord-345222-otfnrarh 601 5 example example NN cord-345222-otfnrarh 601 6 , , , cord-345222-otfnrarh 601 7 several several JJ cord-345222-otfnrarh 601 8 Shigella Shigella NNP cord-345222-otfnrarh 601 9 strains strain NNS cord-345222-otfnrarh 601 10 ( ( -LRB- cord-345222-otfnrarh 601 11 S. S. NNP cord-345222-otfnrarh 601 12 flexneri flexneri NN cord-345222-otfnrarh 601 13 , , , cord-345222-otfnrarh 601 14 S. S. NNP cord-345222-otfnrarh 601 15 dysenteriae dysenteriae NNP cord-345222-otfnrarh 601 16 , , , cord-345222-otfnrarh 601 17 S. S. NNP cord-345222-otfnrarh 601 18 boydii boydii NNP cord-345222-otfnrarh 601 19 , , , cord-345222-otfnrarh 601 20 and and CC cord-345222-otfnrarh 601 21 S. S. NNP cord-345222-otfnrarh 601 22 sonnei sonnei NNP cord-345222-otfnrarh 601 23 ) ) -RRB- cord-345222-otfnrarh 601 24 isolated isolate VBN cord-345222-otfnrarh 601 25 from from IN cord-345222-otfnrarh 601 26 children child NNS cord-345222-otfnrarh 601 27 # # $ cord-345222-otfnrarh 601 28 15 15 CD cord-345222-otfnrarh 601 29 years year NNS cord-345222-otfnrarh 601 30 of of IN cord-345222-otfnrarh 601 31 age age NN cord-345222-otfnrarh 601 32 are be VBP cord-345222-otfnrarh 601 33 resistant resistant JJ cord-345222-otfnrarh 601 34 to to IN cord-345222-otfnrarh 601 35 ampicillin ampicillin NN cord-345222-otfnrarh 601 36 , , , cord-345222-otfnrarh 601 37 cotrimoxazole cotrimoxazole NN cord-345222-otfnrarh 601 38 , , , cord-345222-otfnrarh 601 39 ciprofloxacin ciprofloxacin NN cord-345222-otfnrarh 601 40 , , , cord-345222-otfnrarh 601 41 and and CC cord-345222-otfnrarh 601 42 nalidixic nalidixic RB cord-345222-otfnrarh 601 43 acid acid NNP cord-345222-otfnrarh 601 44 . . . cord-345222-otfnrarh 602 1 Alternatives alternative NNS cord-345222-otfnrarh 602 2 include include VBP cord-345222-otfnrarh 602 3 ceftriaxone ceftriaxone NN cord-345222-otfnrarh 602 4 and and CC cord-345222-otfnrarh 602 5 azithromycin azithromycin NN cord-345222-otfnrarh 602 6 , , , cord-345222-otfnrarh 602 7 but but CC cord-345222-otfnrarh 602 8 ceftriaxone ceftriaxone NN cord-345222-otfnrarh 602 9 is be VBZ cord-345222-otfnrarh 602 10 an an DT cord-345222-otfnrarh 602 11 injectable injectable JJ cord-345222-otfnrarh 602 12 drug drug NN cord-345222-otfnrarh 602 13 and and CC cord-345222-otfnrarh 602 14 azithromycin azithromycin NNP cord-345222-otfnrarh 602 15 has have VBZ cord-345222-otfnrarh 602 16 limited limit VBN cord-345222-otfnrarh 602 17 therapeutic therapeutic JJ cord-345222-otfnrarh 602 18 benefit benefit NN cord-345222-otfnrarh 602 19 , , , cord-345222-otfnrarh 602 20 as as IN cord-345222-otfnrarh 602 21 organisms organism NNS cord-345222-otfnrarh 602 22 easily easily RB cord-345222-otfnrarh 602 23 develop develop VBP cord-345222-otfnrarh 602 24 resistance resistance NN cord-345222-otfnrarh 602 25 to to IN cord-345222-otfnrarh 602 26 it -PRON- PRP cord-345222-otfnrarh 602 27 . . . cord-345222-otfnrarh 603 1 175 175 CD cord-345222-otfnrarh 604 1 It -PRON- PRP cord-345222-otfnrarh 604 2 has have VBZ cord-345222-otfnrarh 604 3 been be VBN cord-345222-otfnrarh 604 4 noted note VBN cord-345222-otfnrarh 604 5 that that IN cord-345222-otfnrarh 604 6 all all DT cord-345222-otfnrarh 604 7 Shigella Shigella NNP cord-345222-otfnrarh 604 8 spp spp NNS cord-345222-otfnrarh 604 9 utilize utilize VBP cord-345222-otfnrarh 604 10 a a DT cord-345222-otfnrarh 604 11 type type NN cord-345222-otfnrarh 604 12 III iii CD cord-345222-otfnrarh 604 13 secretion secretion NN cord-345222-otfnrarh 604 14 system system NN cord-345222-otfnrarh 604 15 to to TO cord-345222-otfnrarh 604 16 translocate translocate VB cord-345222-otfnrarh 604 17 bacterial bacterial JJ cord-345222-otfnrarh 604 18 proteins protein NNS cord-345222-otfnrarh 604 19 -invasins -invasin NNS cord-345222-otfnrarh 604 20 IpaA IpaA NNP cord-345222-otfnrarh 604 21 - - HYPH cord-345222-otfnrarh 604 22 D D NNP cord-345222-otfnrarh 604 23 and and CC cord-345222-otfnrarh 604 24 IpgD ipgd NN cord-345222-otfnrarh 604 25 -into -into CD cord-345222-otfnrarh 604 26 host host NN cord-345222-otfnrarh 604 27 eukaryotic eukaryotic JJ cord-345222-otfnrarh 604 28 cells cell NNS cord-345222-otfnrarh 604 29 to to TO cord-345222-otfnrarh 604 30 initiate initiate VB cord-345222-otfnrarh 604 31 infection infection NN cord-345222-otfnrarh 604 32 . . . cord-345222-otfnrarh 605 1 Because because IN cord-345222-otfnrarh 605 2 they -PRON- PRP cord-345222-otfnrarh 605 3 are be VBP cord-345222-otfnrarh 605 4 common common JJ cord-345222-otfnrarh 605 5 to to IN cord-345222-otfnrarh 605 6 all all DT cord-345222-otfnrarh 605 7 virulent virulent JJ cord-345222-otfnrarh 605 8 Shigella Shigella NNP cord-345222-otfnrarh 605 9 spp spp NNS cord-345222-otfnrarh 605 10 , , , cord-345222-otfnrarh 605 11 they -PRON- PRP cord-345222-otfnrarh 605 12 seem seem VBP cord-345222-otfnrarh 605 13 to to TO cord-345222-otfnrarh 605 14 be be VB cord-345222-otfnrarh 605 15 ideal ideal JJ cord-345222-otfnrarh 605 16 candidate candidate NN cord-345222-otfnrarh 605 17 antigens antigen NNS cord-345222-otfnrarh 605 18 for for IN cord-345222-otfnrarh 605 19 a a DT cord-345222-otfnrarh 605 20 subunit subunit NN cord-345222-otfnrarh 605 21 - - HYPH cord-345222-otfnrarh 605 22 based base VBN cord-345222-otfnrarh 605 23 broad broad JJ cord-345222-otfnrarh 605 24 - - HYPH cord-345222-otfnrarh 605 25 spectrum spectrum NN cord-345222-otfnrarh 605 26 protective protective JJ cord-345222-otfnrarh 605 27 vaccine vaccine NN cord-345222-otfnrarh 605 28 for for IN cord-345222-otfnrarh 605 29 prevention prevention NN cord-345222-otfnrarh 605 30 of of IN cord-345222-otfnrarh 605 31 shigellosis shigellosis NNP cord-345222-otfnrarh 605 32 . . . cord-345222-otfnrarh 606 1 176 176 CD cord-345222-otfnrarh 606 2 Vibrio vibrio NN cord-345222-otfnrarh 606 3 cholerae cholerae NN cord-345222-otfnrarh 606 4 strains strain NNS cord-345222-otfnrarh 606 5 from from IN cord-345222-otfnrarh 606 6 endemic endemic JJ cord-345222-otfnrarh 606 7 outbreaks outbreak NNS cord-345222-otfnrarh 606 8 within within IN cord-345222-otfnrarh 606 9 the the DT cord-345222-otfnrarh 606 10 last last JJ cord-345222-otfnrarh 606 11 decade decade NN cord-345222-otfnrarh 606 12 revealed reveal VBD cord-345222-otfnrarh 606 13 patterns pattern NNS cord-345222-otfnrarh 606 14 of of IN cord-345222-otfnrarh 606 15 antibiotic antibiotic JJ cord-345222-otfnrarh 606 16 resistance resistance NN cord-345222-otfnrarh 606 17 to to IN cord-345222-otfnrarh 606 18 ampicillin ampicillin NN cord-345222-otfnrarh 606 19 , , , cord-345222-otfnrarh 606 20 tetracycline tetracycline NN cord-345222-otfnrarh 606 21 , , , cord-345222-otfnrarh 606 22 and and CC cord-345222-otfnrarh 606 23 trimethoprim trimethoprim NNP cord-345222-otfnrarh 606 24 correlated correlate VBD cord-345222-otfnrarh 606 25 with with IN cord-345222-otfnrarh 606 26 widespread widespread JJ cord-345222-otfnrarh 606 27 therapeutic therapeutic JJ cord-345222-otfnrarh 606 28 and and CC cord-345222-otfnrarh 606 29 prophylactic prophylactic JJ cord-345222-otfnrarh 606 30 administration administration NN cord-345222-otfnrarh 606 31 of of IN cord-345222-otfnrarh 606 32 antibiotics antibiotic NNS cord-345222-otfnrarh 606 33 . . . cord-345222-otfnrarh 607 1 177 177 CD cord-345222-otfnrarh 608 1 Treating treat VBG cord-345222-otfnrarh 608 2 severe severe JJ cord-345222-otfnrarh 608 3 cases case NNS cord-345222-otfnrarh 608 4 of of IN cord-345222-otfnrarh 608 5 cholera cholera NN cord-345222-otfnrarh 608 6 with with IN cord-345222-otfnrarh 608 7 antibiotics antibiotic NNS cord-345222-otfnrarh 608 8 is be VBZ cord-345222-otfnrarh 608 9 important important JJ cord-345222-otfnrarh 608 10 , , , cord-345222-otfnrarh 608 11 but but CC cord-345222-otfnrarh 608 12 the the DT cord-345222-otfnrarh 608 13 continuing continue VBG cord-345222-otfnrarh 608 14 spread spread NN cord-345222-otfnrarh 608 15 of of IN cord-345222-otfnrarh 608 16 resistance resistance NN cord-345222-otfnrarh 608 17 to to IN cord-345222-otfnrarh 608 18 the the DT cord-345222-otfnrarh 608 19 most most RBS cord-345222-otfnrarh 608 20 important important JJ cord-345222-otfnrarh 608 21 therapeutic therapeutic JJ cord-345222-otfnrarh 608 22 agents agent NNS cord-345222-otfnrarh 608 23 is be VBZ cord-345222-otfnrarh 608 24 a a DT cord-345222-otfnrarh 608 25 matter matter NN cord-345222-otfnrarh 608 26 of of IN cord-345222-otfnrarh 608 27 concern concern NN cord-345222-otfnrarh 608 28 , , , cord-345222-otfnrarh 608 29 as as IN cord-345222-otfnrarh 608 30 some some DT cord-345222-otfnrarh 608 31 strains strain NNS cord-345222-otfnrarh 608 32 have have VBP cord-345222-otfnrarh 608 33 either either DT cord-345222-otfnrarh 608 34 intermediate intermediate JJ cord-345222-otfnrarh 608 35 resistance resistance NN cord-345222-otfnrarh 608 36 or or CC cord-345222-otfnrarh 608 37 are be VBP cord-345222-otfnrarh 608 38 resistant resistant JJ cord-345222-otfnrarh 608 39 to to IN cord-345222-otfnrarh 608 40 ceftriaxone ceftriaxone NN cord-345222-otfnrarh 608 41 , , , cord-345222-otfnrarh 608 42 ciprofloxacin ciprofloxacin NN cord-345222-otfnrarh 608 43 , , , cord-345222-otfnrarh 608 44 and and CC cord-345222-otfnrarh 608 45 tetracycline tetracycline NN cord-345222-otfnrarh 608 46 . . . cord-345222-otfnrarh 609 1 178 178 CD cord-345222-otfnrarh 610 1 The the DT cord-345222-otfnrarh 610 2 most most RBS cord-345222-otfnrarh 610 3 common common JJ cord-345222-otfnrarh 610 4 clinical clinical JJ cord-345222-otfnrarh 610 5 manifestation manifestation NN cord-345222-otfnrarh 610 6 of of IN cord-345222-otfnrarh 610 7 a a DT cord-345222-otfnrarh 610 8 Yersinia Yersinia NNP cord-345222-otfnrarh 610 9 enterocolitica enterocolitica NNP cord-345222-otfnrarh 610 10 infection infection NN cord-345222-otfnrarh 610 11 is be VBZ cord-345222-otfnrarh 610 12 a a DT cord-345222-otfnrarh 610 13 self self NN cord-345222-otfnrarh 610 14 - - HYPH cord-345222-otfnrarh 610 15 limited limit VBN cord-345222-otfnrarh 610 16 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 610 17 that that WDT cord-345222-otfnrarh 610 18 resolved resolve VBD cord-345222-otfnrarh 610 19 spontaneously spontaneously RB cord-345222-otfnrarh 610 20 within within IN cord-345222-otfnrarh 610 21 2 2 CD cord-345222-otfnrarh 610 22 weeks week NNS cord-345222-otfnrarh 610 23 . . . cord-345222-otfnrarh 611 1 179 179 CD cord-345222-otfnrarh 612 1 Y. Y. NNP cord-345222-otfnrarh 612 2 enterocolitica enterocolitica NNP cord-345222-otfnrarh 612 3 usually usually RB cord-345222-otfnrarh 612 4 shows show VBZ cord-345222-otfnrarh 612 5 in in IN cord-345222-otfnrarh 612 6 vitro vitro FW cord-345222-otfnrarh 612 7 susceptibility susceptibility NN cord-345222-otfnrarh 612 8 to to IN cord-345222-otfnrarh 612 9 aminoglycosides aminoglycoside NNS cord-345222-otfnrarh 612 10 , , , cord-345222-otfnrarh 612 11 chloramphenicol chloramphenicol NNP cord-345222-otfnrarh 612 12 , , , cord-345222-otfnrarh 612 13 doxycycline doxycycline NNP cord-345222-otfnrarh 612 14 , , , cord-345222-otfnrarh 612 15 cotrimoxazole cotrimoxazole NN cord-345222-otfnrarh 612 16 , , , cord-345222-otfnrarh 612 17 third third JJ cord-345222-otfnrarh 612 18 - - HYPH cord-345222-otfnrarh 612 19 generation generation NN cord-345222-otfnrarh 612 20 cephalosporins cephalosporin NNS cord-345222-otfnrarh 612 21 , , , cord-345222-otfnrarh 612 22 carabapenems carabapenem NNS cord-345222-otfnrarh 612 23 , , , cord-345222-otfnrarh 612 24 and and CC cord-345222-otfnrarh 612 25 fluoroquinolones fluoroquinolone NNS cord-345222-otfnrarh 612 26 . . . cord-345222-otfnrarh 613 1 180 180 CD cord-345222-otfnrarh 614 1 Recently recently RB cord-345222-otfnrarh 614 2 , , , cord-345222-otfnrarh 614 3 in in IN cord-345222-otfnrarh 614 4 a a DT cord-345222-otfnrarh 614 5 case case NN cord-345222-otfnrarh 614 6 - - HYPH cord-345222-otfnrarh 614 7 control control NN cord-345222-otfnrarh 614 8 study study NN cord-345222-otfnrarh 614 9 conducted conduct VBN cord-345222-otfnrarh 614 10 among among IN cord-345222-otfnrarh 614 11 children child NNS cord-345222-otfnrarh 614 12 aged age VBN cord-345222-otfnrarh 614 13 less less JJR cord-345222-otfnrarh 614 14 than than IN cord-345222-otfnrarh 614 15 12 12 CD cord-345222-otfnrarh 614 16 years year NNS cord-345222-otfnrarh 614 17 , , , cord-345222-otfnrarh 614 18 it -PRON- PRP cord-345222-otfnrarh 614 19 was be VBD cord-345222-otfnrarh 614 20 found find VBN cord-345222-otfnrarh 614 21 that that IN cord-345222-otfnrarh 614 22 Y. Y. NNP cord-345222-otfnrarh 614 23 enterocolitica enterocolitica NNP cord-345222-otfnrarh 614 24 is be VBZ cord-345222-otfnrarh 614 25 generally generally RB cord-345222-otfnrarh 614 26 susceptible susceptible JJ cord-345222-otfnrarh 614 27 to to IN cord-345222-otfnrarh 614 28 meropenem meropenem NNP cord-345222-otfnrarh 614 29 ( ( -LRB- cord-345222-otfnrarh 614 30 100 100 CD cord-345222-otfnrarh 614 31 % % NN cord-345222-otfnrarh 614 32 ) ) -RRB- cord-345222-otfnrarh 614 33 , , , cord-345222-otfnrarh 614 34 ceftriaxone ceftriaxone NN cord-345222-otfnrarh 614 35 ( ( -LRB- cord-345222-otfnrarh 614 36 94 94 CD cord-345222-otfnrarh 614 37 % % NN cord-345222-otfnrarh 614 38 ) ) -RRB- cord-345222-otfnrarh 614 39 , , , cord-345222-otfnrarh 614 40 and and CC cord-345222-otfnrarh 614 41 ciprofloxacin ciprofloxacin NNP cord-345222-otfnrarh 614 42 ( ( -LRB- cord-345222-otfnrarh 614 43 94 94 CD cord-345222-otfnrarh 614 44 % % NN cord-345222-otfnrarh 614 45 ) ) -RRB- cord-345222-otfnrarh 614 46 , , , cord-345222-otfnrarh 614 47 followed follow VBN cord-345222-otfnrarh 614 48 by by IN cord-345222-otfnrarh 614 49 ceftazidime ceftazidime NNP cord-345222-otfnrarh 614 50 ( ( -LRB- cord-345222-otfnrarh 614 51 88 88 CD cord-345222-otfnrarh 614 52 % % NN cord-345222-otfnrarh 614 53 ) ) -RRB- cord-345222-otfnrarh 614 54 and and CC cord-345222-otfnrarh 614 55 amikacin amikacin NNS cord-345222-otfnrarh 614 56 ( ( -LRB- cord-345222-otfnrarh 614 57 81 81 CD cord-345222-otfnrarh 614 58 % % NN cord-345222-otfnrarh 614 59 ) ) -RRB- cord-345222-otfnrarh 614 60 . . . cord-345222-otfnrarh 615 1 Almost almost RB cord-345222-otfnrarh 615 2 all all DT cord-345222-otfnrarh 615 3 Y. Y. NNP cord-345222-otfnrarh 615 4 enterocolitica enterocolitica NNP cord-345222-otfnrarh 615 5 was be VBD cord-345222-otfnrarh 615 6 resistant resistant JJ cord-345222-otfnrarh 615 7 to to IN cord-345222-otfnrarh 615 8 ampicillin ampicillin NN cord-345222-otfnrarh 615 9 . . . cord-345222-otfnrarh 616 1 57 57 CD cord-345222-otfnrarh 616 2 Fungal fungal JJ cord-345222-otfnrarh 616 3 Fungal fungal JJ cord-345222-otfnrarh 616 4 infections infection NNS cord-345222-otfnrarh 616 5 of of IN cord-345222-otfnrarh 616 6 the the DT cord-345222-otfnrarh 616 7 gastrointestinal gastrointestinal JJ cord-345222-otfnrarh 616 8 tract tract NN cord-345222-otfnrarh 616 9 are be VBP cord-345222-otfnrarh 616 10 not not RB cord-345222-otfnrarh 616 11 common common JJ cord-345222-otfnrarh 616 12 in in IN cord-345222-otfnrarh 616 13 children child NNS cord-345222-otfnrarh 616 14 , , , cord-345222-otfnrarh 616 15 especially especially RB cord-345222-otfnrarh 616 16 in in IN cord-345222-otfnrarh 616 17 immunocompetent immunocompetent JJ cord-345222-otfnrarh 616 18 ones one NNS cord-345222-otfnrarh 616 19 . . . cord-345222-otfnrarh 617 1 In in IN cord-345222-otfnrarh 617 2 the the DT cord-345222-otfnrarh 617 3 neonatal neonatal JJ cord-345222-otfnrarh 617 4 period period NN cord-345222-otfnrarh 617 5 , , , cord-345222-otfnrarh 617 6 Candida candida NN cord-345222-otfnrarh 617 7 infections infection NNS cord-345222-otfnrarh 617 8 frequently frequently RB cord-345222-otfnrarh 617 9 develop develop VBP cord-345222-otfnrarh 617 10 into into IN cord-345222-otfnrarh 617 11 systemic systemic JJ cord-345222-otfnrarh 617 12 forms form NNS cord-345222-otfnrarh 617 13 . . . cord-345222-otfnrarh 618 1 82 82 CD cord-345222-otfnrarh 618 2 Fluconazole Fluconazole NNP cord-345222-otfnrarh 618 3 prophylaxis prophylaxis NN cord-345222-otfnrarh 618 4 in in IN cord-345222-otfnrarh 618 5 infants infant NNS cord-345222-otfnrarh 618 6 , , , cord-345222-otfnrarh 618 7 1000 1000 CD cord-345222-otfnrarh 618 8 g g NN cord-345222-otfnrarh 618 9 ( ( -LRB- cord-345222-otfnrarh 618 10 3 3 CD cord-345222-otfnrarh 618 11 mg mg NNP cord-345222-otfnrarh 618 12 / / SYM cord-345222-otfnrarh 618 13 kg kg NNS cord-345222-otfnrarh 618 14 twice twice PDT cord-345222-otfnrarh 618 15 a a DT cord-345222-otfnrarh 618 16 week week NN cord-345222-otfnrarh 618 17 ) ) -RRB- cord-345222-otfnrarh 618 18 , , , cord-345222-otfnrarh 618 19 while while IN cord-345222-otfnrarh 618 20 intravenous intravenous JJ cord-345222-otfnrarh 618 21 access access NN cord-345222-otfnrarh 618 22 is be VBZ cord-345222-otfnrarh 618 23 required require VBN cord-345222-otfnrarh 618 24 , , , cord-345222-otfnrarh 618 25 appears appear VBZ cord-345222-otfnrarh 618 26 to to TO cord-345222-otfnrarh 618 27 be be VB cord-345222-otfnrarh 618 28 safe safe JJ cord-345222-otfnrarh 618 29 and and CC cord-345222-otfnrarh 618 30 effective effective JJ cord-345222-otfnrarh 618 31 in in IN cord-345222-otfnrarh 618 32 preventing prevent VBG cord-345222-otfnrarh 618 33 invasive invasive JJ cord-345222-otfnrarh 618 34 Candida Candida NNP cord-345222-otfnrarh 618 35 infections infection NNS cord-345222-otfnrarh 618 36 with with IN cord-345222-otfnrarh 618 37 or or CC cord-345222-otfnrarh 618 38 without without IN cord-345222-otfnrarh 618 39 diarrhea diarrhea NN cord-345222-otfnrarh 618 40 , , , cord-345222-otfnrarh 618 41 while while IN cord-345222-otfnrarh 618 42 attenuating attenuate VBG cord-345222-otfnrarh 618 43 the the DT cord-345222-otfnrarh 618 44 emergence emergence NN cord-345222-otfnrarh 618 45 of of IN cord-345222-otfnrarh 618 46 fungal fungal JJ cord-345222-otfnrarh 618 47 resistance resistance NN cord-345222-otfnrarh 618 48 . . . cord-345222-otfnrarh 619 1 88 88 CD cord-345222-otfnrarh 619 2 , , , cord-345222-otfnrarh 619 3 181 181 CD cord-345222-otfnrarh 619 4 New New NNP cord-345222-otfnrarh 619 5 echinocandines echinocandine NNS cord-345222-otfnrarh 619 6 -anidulafungin -anidulafungin NN cord-345222-otfnrarh 619 7 , , , cord-345222-otfnrarh 619 8 caspofungin caspofungin NNP cord-345222-otfnrarh 619 9 , , , cord-345222-otfnrarh 619 10 and and CC cord-345222-otfnrarh 619 11 micafungin micafungin NNP cord-345222-otfnrarh 619 12 , , , cord-345222-otfnrarh 619 13 recently recently RB cord-345222-otfnrarh 619 14 introduced introduce VBD cord-345222-otfnrarh 619 15 -seem -seem , cord-345222-otfnrarh 619 16 to to TO cord-345222-otfnrarh 619 17 have have VB cord-345222-otfnrarh 619 18 some some DT cord-345222-otfnrarh 619 19 advantages advantage NNS cord-345222-otfnrarh 619 20 over over IN cord-345222-otfnrarh 619 21 fluconazole fluconazole NN cord-345222-otfnrarh 619 22 and and CC cord-345222-otfnrarh 619 23 amphotericin amphotericin NNS cord-345222-otfnrarh 619 24 B B NNP cord-345222-otfnrarh 619 25 , , , cord-345222-otfnrarh 619 26 as as IN cord-345222-otfnrarh 619 27 they -PRON- PRP cord-345222-otfnrarh 619 28 better better RB cord-345222-otfnrarh 619 29 meet meet VBP cord-345222-otfnrarh 619 30 the the DT cord-345222-otfnrarh 619 31 needs need NNS cord-345222-otfnrarh 619 32 of of IN cord-345222-otfnrarh 619 33 pediatric pediatric JJ cord-345222-otfnrarh 619 34 patients patient NNS cord-345222-otfnrarh 619 35 , , , cord-345222-otfnrarh 619 36 neonates neonate NNS cord-345222-otfnrarh 619 37 , , , cord-345222-otfnrarh 619 38 and and CC cord-345222-otfnrarh 619 39 in in IN cord-345222-otfnrarh 619 40 particular particular JJ cord-345222-otfnrarh 619 41 preterm preterm JJ cord-345222-otfnrarh 619 42 infants infant NNS cord-345222-otfnrarh 619 43 with with IN cord-345222-otfnrarh 619 44 invasive invasive JJ cord-345222-otfnrarh 619 45 candidiasis candidiasi NNS cord-345222-otfnrarh 619 46 and/or and/or CC cord-345222-otfnrarh 619 47 diarrhea diarrhea NN cord-345222-otfnrarh 619 48 from from IN cord-345222-otfnrarh 619 49 Candida Candida NNP cord-345222-otfnrarh 619 50 spp spp NN cord-345222-otfnrarh 619 51 infection infection NN cord-345222-otfnrarh 619 52 . . . cord-345222-otfnrarh 620 1 Micafungin Micafungin NNP cord-345222-otfnrarh 620 2 , , , cord-345222-otfnrarh 620 3 a a DT cord-345222-otfnrarh 620 4 dose dose NN cord-345222-otfnrarh 620 5 - - HYPH cord-345222-otfnrarh 620 6 dependent dependent JJ cord-345222-otfnrarh 620 7 candidacidal candidacidal JJ cord-345222-otfnrarh 620 8 agent agent NN cord-345222-otfnrarh 620 9 with with IN cord-345222-otfnrarh 620 10 excellent excellent JJ cord-345222-otfnrarh 620 11 in in FW cord-345222-otfnrarh 620 12 vitro vitro FW cord-345222-otfnrarh 620 13 efficacy efficacy NN cord-345222-otfnrarh 620 14 against against IN cord-345222-otfnrarh 620 15 most most JJS cord-345222-otfnrarh 620 16 Candida Candida NNP cord-345222-otfnrarh 620 17 spp spp NNS cord-345222-otfnrarh 620 18 , , , cord-345222-otfnrarh 620 19 including include VBG cord-345222-otfnrarh 620 20 species specie NNS cord-345222-otfnrarh 620 21 resistant resistant JJ cord-345222-otfnrarh 620 22 to to IN cord-345222-otfnrarh 620 23 amphotericin amphotericin NNS cord-345222-otfnrarh 620 24 B b NN cord-345222-otfnrarh 620 25 , , , cord-345222-otfnrarh 620 26 is be VBZ cord-345222-otfnrarh 620 27 approved approve VBN cord-345222-otfnrarh 620 28 for for IN cord-345222-otfnrarh 620 29 the the DT cord-345222-otfnrarh 620 30 treatment treatment NN cord-345222-otfnrarh 620 31 of of IN cord-345222-otfnrarh 620 32 invasive invasive JJ cord-345222-otfnrarh 620 33 candidiasis candidiasi NNS cord-345222-otfnrarh 620 34 in in IN cord-345222-otfnrarh 620 35 children child NNS cord-345222-otfnrarh 620 36 , , , cord-345222-otfnrarh 620 37 including include VBG cord-345222-otfnrarh 620 38 preterm preterm JJR cord-345222-otfnrarh 620 39 infants infant NNS cord-345222-otfnrarh 620 40 aged age VBN cord-345222-otfnrarh 620 41 less less JJR cord-345222-otfnrarh 620 42 than than IN cord-345222-otfnrarh 620 43 3 3 CD cord-345222-otfnrarh 620 44 months month NNS cord-345222-otfnrarh 620 45 . . . cord-345222-otfnrarh 621 1 Efficacy efficacy NN cord-345222-otfnrarh 621 2 and and CC cord-345222-otfnrarh 621 3 safety safety NN cord-345222-otfnrarh 621 4 were be VBD cord-345222-otfnrarh 621 5 demonstrated demonstrate VBN cord-345222-otfnrarh 621 6 in in IN cord-345222-otfnrarh 621 7 comparison comparison NN cord-345222-otfnrarh 621 8 with with IN cord-345222-otfnrarh 621 9 liposomal liposomal JJ cord-345222-otfnrarh 621 10 amphotericin amphotericin NNS cord-345222-otfnrarh 621 11 B B NNP cord-345222-otfnrarh 621 12 and and CC cord-345222-otfnrarh 621 13 fluconazole fluconazole NN cord-345222-otfnrarh 621 14 . . . cord-345222-otfnrarh 622 1 The the DT cord-345222-otfnrarh 622 2 most most RBS cord-345222-otfnrarh 622 3 appropriate appropriate JJ cord-345222-otfnrarh 622 4 dose dose NN cord-345222-otfnrarh 622 5 in in IN cord-345222-otfnrarh 622 6 children child NNS cord-345222-otfnrarh 622 7 weighing weigh VBG cord-345222-otfnrarh 622 8 less less JJR cord-345222-otfnrarh 622 9 than than IN cord-345222-otfnrarh 622 10 40 40 CD cord-345222-otfnrarh 622 11 kg kg NNS cord-345222-otfnrarh 622 12 is be VBZ cord-345222-otfnrarh 622 13 2 2 CD cord-345222-otfnrarh 622 14 mg mg NNP cord-345222-otfnrarh 622 15 / / SYM cord-345222-otfnrarh 622 16 kg kg NNP cord-345222-otfnrarh 622 17 / / SYM cord-345222-otfnrarh 622 18 day day NN cord-345222-otfnrarh 622 19 in in IN cord-345222-otfnrarh 622 20 the the DT cord-345222-otfnrarh 622 21 treatment treatment NN cord-345222-otfnrarh 622 22 of of IN cord-345222-otfnrarh 622 23 invasive invasive JJ cord-345222-otfnrarh 622 24 candidiasis candidiasi NNS cord-345222-otfnrarh 622 25 and and CC cord-345222-otfnrarh 622 26 or or CC cord-345222-otfnrarh 622 27 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 622 28 and and CC cord-345222-otfnrarh 622 29 1 1 CD cord-345222-otfnrarh 622 30 mg mg NNP cord-345222-otfnrarh 622 31 / / SYM cord-345222-otfnrarh 622 32 kg kg NNP cord-345222-otfnrarh 622 33 / / SYM cord-345222-otfnrarh 622 34 day day NN cord-345222-otfnrarh 622 35 as as IN cord-345222-otfnrarh 622 36 prophylaxis prophylaxis NN cord-345222-otfnrarh 622 37 . . . cord-345222-otfnrarh 623 1 In in IN cord-345222-otfnrarh 623 2 premature premature JJ cord-345222-otfnrarh 623 3 infants infant NNS cord-345222-otfnrarh 623 4 , , , cord-345222-otfnrarh 623 5 the the DT cord-345222-otfnrarh 623 6 most most RBS cord-345222-otfnrarh 623 7 appropriate appropriate JJ cord-345222-otfnrarh 623 8 doses dose NNS cord-345222-otfnrarh 623 9 to to TO cord-345222-otfnrarh 623 10 achieve achieve VB cord-345222-otfnrarh 623 11 appropriate appropriate JJ cord-345222-otfnrarh 623 12 levels level NNS cord-345222-otfnrarh 623 13 in in IN cord-345222-otfnrarh 623 14 the the DT cord-345222-otfnrarh 623 15 brain brain NN cord-345222-otfnrarh 623 16 parenchyma parenchyma NN cord-345222-otfnrarh 623 17 are be VBP cord-345222-otfnrarh 623 18 7 7 CD cord-345222-otfnrarh 623 19 mg mg NN cord-345222-otfnrarh 623 20 / / SYM cord-345222-otfnrarh 623 21 kg kg NNP cord-345222-otfnrarh 623 22 / / SYM cord-345222-otfnrarh 623 23 day day NN cord-345222-otfnrarh 623 24 in in IN cord-345222-otfnrarh 623 25 infants infant NNS cord-345222-otfnrarh 623 26 weighing weigh VBG cord-345222-otfnrarh 623 27 more more JJR cord-345222-otfnrarh 623 28 than than IN cord-345222-otfnrarh 623 29 1,000 1,000 CD cord-345222-otfnrarh 623 30 g g NN cord-345222-otfnrarh 623 31 and and CC cord-345222-otfnrarh 623 32 10 10 CD cord-345222-otfnrarh 623 33 mg mg NNP cord-345222-otfnrarh 623 34 / / SYM cord-345222-otfnrarh 623 35 kg kg NNP cord-345222-otfnrarh 623 36 / / SYM cord-345222-otfnrarh 623 37 day day NN cord-345222-otfnrarh 623 38 in in IN cord-345222-otfnrarh 623 39 those those DT cord-345222-otfnrarh 623 40 weighing weigh VBG cord-345222-otfnrarh 623 41 less less JJR cord-345222-otfnrarh 623 42 than than IN cord-345222-otfnrarh 623 43 1,000 1,000 CD cord-345222-otfnrarh 623 44 g g NN cord-345222-otfnrarh 623 45 , , , cord-345222-otfnrarh 623 46 respectively respectively RB cord-345222-otfnrarh 623 47 . . . cord-345222-otfnrarh 624 1 Micafungin Micafungin NNP cord-345222-otfnrarh 624 2 has have VBZ cord-345222-otfnrarh 624 3 few few JJ cord-345222-otfnrarh 624 4 drug drug NN cord-345222-otfnrarh 624 5 - - HYPH cord-345222-otfnrarh 624 6 drug drug NN cord-345222-otfnrarh 624 7 interactions interaction NNS cord-345222-otfnrarh 624 8 and and CC cord-345222-otfnrarh 624 9 an an DT cord-345222-otfnrarh 624 10 acceptable acceptable JJ cord-345222-otfnrarh 624 11 safety safety NN cord-345222-otfnrarh 624 12 profile profile NN cord-345222-otfnrarh 624 13 thus thus RB cord-345222-otfnrarh 624 14 providing provide VBG cord-345222-otfnrarh 624 15 a a DT cord-345222-otfnrarh 624 16 promising promising JJ cord-345222-otfnrarh 624 17 drug drug NN cord-345222-otfnrarh 624 18 in in IN cord-345222-otfnrarh 624 19 the the DT cord-345222-otfnrarh 624 20 prophylactic prophylactic JJ cord-345222-otfnrarh 624 21 and and CC cord-345222-otfnrarh 624 22 therapeutic therapeutic JJ cord-345222-otfnrarh 624 23 management management NN cord-345222-otfnrarh 624 24 of of IN cord-345222-otfnrarh 624 25 invasive invasive JJ cord-345222-otfnrarh 624 26 candidiasis candidiasi NNS cord-345222-otfnrarh 624 27 . . . cord-345222-otfnrarh 625 1 Micafungin Micafungin NNP cord-345222-otfnrarh 625 2 has have VBZ cord-345222-otfnrarh 625 3 few few JJ cord-345222-otfnrarh 625 4 drug drug NN cord-345222-otfnrarh 625 5 - - HYPH cord-345222-otfnrarh 625 6 drug drug NN cord-345222-otfnrarh 625 7 interactions interaction NNS cord-345222-otfnrarh 625 8 , , , cord-345222-otfnrarh 625 9 and and CC cord-345222-otfnrarh 625 10 an an DT cord-345222-otfnrarh 625 11 acceptable acceptable JJ cord-345222-otfnrarh 625 12 safety safety NN cord-345222-otfnrarh 625 13 profile profile NN cord-345222-otfnrarh 625 14 . . . cord-345222-otfnrarh 626 1 [ [ -LRB- cord-345222-otfnrarh 626 2 182 182 CD cord-345222-otfnrarh 626 3 ] ] -RRB- cord-345222-otfnrarh 626 4 [ [ -LRB- cord-345222-otfnrarh 626 5 183 183 CD cord-345222-otfnrarh 626 6 ] ] -RRB- cord-345222-otfnrarh 626 7 [ [ -LRB- cord-345222-otfnrarh 626 8 184 184 CD cord-345222-otfnrarh 626 9 ] ] -RRB- cord-345222-otfnrarh 627 1 Data datum NNS cord-345222-otfnrarh 627 2 from from IN cord-345222-otfnrarh 627 3 randomized randomized JJ cord-345222-otfnrarh 627 4 trials trial NNS cord-345222-otfnrarh 627 5 conducted conduct VBN cord-345222-otfnrarh 627 6 in in IN cord-345222-otfnrarh 627 7 pediatric pediatric JJ cord-345222-otfnrarh 627 8 and and CC cord-345222-otfnrarh 627 9 adult adult NN cord-345222-otfnrarh 627 10 patients patient NNS cord-345222-otfnrarh 627 11 showed show VBD cord-345222-otfnrarh 627 12 through through IN cord-345222-otfnrarh 627 13 a a DT cord-345222-otfnrarh 627 14 subgroup subgroup NN cord-345222-otfnrarh 627 15 analysis analysis NN cord-345222-otfnrarh 627 16 that that WDT cord-345222-otfnrarh 627 17 both both DT cord-345222-otfnrarh 627 18 caspofungin caspofungin NNP cord-345222-otfnrarh 627 19 and and CC cord-345222-otfnrarh 627 20 micafungin micafungin NNP cord-345222-otfnrarh 627 21 are be VBP cord-345222-otfnrarh 627 22 effective effective JJ cord-345222-otfnrarh 627 23 and and CC cord-345222-otfnrarh 627 24 well well RB cord-345222-otfnrarh 627 25 tolerated tolerate VBN cord-345222-otfnrarh 627 26 also also RB cord-345222-otfnrarh 627 27 in in IN cord-345222-otfnrarh 627 28 neonates neonate NNS cord-345222-otfnrarh 627 29 . . . cord-345222-otfnrarh 628 1 185 185 CD cord-345222-otfnrarh 628 2 , , , cord-345222-otfnrarh 628 3 186 186 CD cord-345222-otfnrarh 628 4 Parasitic parasitic JJ cord-345222-otfnrarh 629 1 -protozoan -protozoan : cord-345222-otfnrarh 630 1 The the DT cord-345222-otfnrarh 630 2 major major JJ cord-345222-otfnrarh 630 3 causes cause NNS cord-345222-otfnrarh 630 4 of of IN cord-345222-otfnrarh 630 5 diarrhea diarrhea NN cord-345222-otfnrarh 630 6 worldwide worldwide RB cord-345222-otfnrarh 630 7 in in IN cord-345222-otfnrarh 630 8 children child NNS cord-345222-otfnrarh 630 9 are be VBP cord-345222-otfnrarh 630 10 Cryptosporidium cryptosporidium NN cord-345222-otfnrarh 630 11 parvum parvum NN cord-345222-otfnrarh 630 12 , , , cord-345222-otfnrarh 630 13 Giardia Giardia NNP cord-345222-otfnrarh 630 14 lamblia lamblia NNP cord-345222-otfnrarh 630 15 , , , cord-345222-otfnrarh 630 16 and and CC cord-345222-otfnrarh 630 17 Entamoeba Entamoeba NNP cord-345222-otfnrarh 630 18 histolytica histolytica NNP cord-345222-otfnrarh 630 19 : : : cord-345222-otfnrarh 630 20 " " `` cord-345222-otfnrarh 630 21 the the DT cord-345222-otfnrarh 630 22 neglected neglect VBN cord-345222-otfnrarh 630 23 parasitic parasitic JJ cord-345222-otfnrarh 630 24 disease disease NN cord-345222-otfnrarh 630 25 . . . cord-345222-otfnrarh 631 1 " " `` cord-345222-otfnrarh 631 2 Cryptosporidium cryptosporidium NN cord-345222-otfnrarh 631 3 is be VBZ cord-345222-otfnrarh 631 4 a a DT cord-345222-otfnrarh 631 5 diarrheagenic diarrheagenic JJ cord-345222-otfnrarh 631 6 protozoan protozoan NN cord-345222-otfnrarh 631 7 pathogen pathogen NN cord-345222-otfnrarh 631 8 for for IN cord-345222-otfnrarh 631 9 children child NNS cord-345222-otfnrarh 631 10 , , , cord-345222-otfnrarh 631 11 and and CC cord-345222-otfnrarh 631 12 immunosuppressed immunosuppressed JJ cord-345222-otfnrarh 631 13 individuals individual NNS cord-345222-otfnrarh 631 14 are be VBP cord-345222-otfnrarh 631 15 disproportionately disproportionately RB cord-345222-otfnrarh 631 16 affected affect VBN cord-345222-otfnrarh 631 17 . . . cord-345222-otfnrarh 632 1 Until until IN cord-345222-otfnrarh 632 2 a a DT cord-345222-otfnrarh 632 3 few few JJ cord-345222-otfnrarh 632 4 years year NNS cord-345222-otfnrarh 632 5 ago ago RB cord-345222-otfnrarh 632 6 , , , cord-345222-otfnrarh 632 7 the the DT cord-345222-otfnrarh 632 8 most most RBS cord-345222-otfnrarh 632 9 commonly commonly RB cord-345222-otfnrarh 632 10 used use VBN cord-345222-otfnrarh 632 11 treatments treatment NNS cord-345222-otfnrarh 632 12 , , , cord-345222-otfnrarh 632 13 only only RB cord-345222-otfnrarh 632 14 partially partially RB cord-345222-otfnrarh 632 15 effective effective JJ cord-345222-otfnrarh 632 16 , , , cord-345222-otfnrarh 632 17 were be VBD cord-345222-otfnrarh 632 18 paromomycin paromomycin NNS cord-345222-otfnrarh 632 19 and and CC cord-345222-otfnrarh 632 20 azithromycin azithromycin NN cord-345222-otfnrarh 632 21 . . . cord-345222-otfnrarh 633 1 Recent recent JJ cord-345222-otfnrarh 633 2 investigations investigation NNS cord-345222-otfnrarh 633 3 have have VBP cord-345222-otfnrarh 633 4 focused focus VBN cord-345222-otfnrarh 633 5 on on IN cord-345222-otfnrarh 633 6 nitazoxanide nitazoxanide NNP cord-345222-otfnrarh 633 7 , , , cord-345222-otfnrarh 633 8 as as IN cord-345222-otfnrarh 633 9 it -PRON- PRP cord-345222-otfnrarh 633 10 significantly significantly RB cord-345222-otfnrarh 633 11 shortens shorten VBZ cord-345222-otfnrarh 633 12 the the DT cord-345222-otfnrarh 633 13 duration duration NN cord-345222-otfnrarh 633 14 of of IN cord-345222-otfnrarh 633 15 diarrhea diarrhea NN cord-345222-otfnrarh 633 16 and and CC cord-345222-otfnrarh 633 17 decreases decrease VBZ cord-345222-otfnrarh 633 18 mortality mortality NN cord-345222-otfnrarh 633 19 in in IN cord-345222-otfnrarh 633 20 malnourished malnourished JJ cord-345222-otfnrarh 633 21 children child NNS cord-345222-otfnrarh 633 22 . . . cord-345222-otfnrarh 634 1 Nitazoxanide Nitazoxanide NNP cord-345222-otfnrarh 634 2 is be VBZ cord-345222-otfnrarh 634 3 not not RB cord-345222-otfnrarh 634 4 effective effective JJ cord-345222-otfnrarh 634 5 without without IN cord-345222-otfnrarh 634 6 an an DT cord-345222-otfnrarh 634 7 appropriate appropriate JJ cord-345222-otfnrarh 634 8 immune immune JJ cord-345222-otfnrarh 634 9 response response NN cord-345222-otfnrarh 634 10 , , , cord-345222-otfnrarh 634 11 as as IN cord-345222-otfnrarh 634 12 in in IN cord-345222-otfnrarh 634 13 AIDS AIDS NNP cord-345222-otfnrarh 634 14 patients patient NNS cord-345222-otfnrarh 634 15 . . . cord-345222-otfnrarh 635 1 187 187 CD cord-345222-otfnrarh 635 2 , , , cord-345222-otfnrarh 635 3 188 188 CD cord-345222-otfnrarh 635 4 Giardia Giardia NNP cord-345222-otfnrarh 635 5 lamblia lamblia NN cord-345222-otfnrarh 635 6 is be VBZ cord-345222-otfnrarh 635 7 a a DT cord-345222-otfnrarh 635 8 diarrheagenic diarrheagenic JJ cord-345222-otfnrarh 635 9 protozoan protozoan NN cord-345222-otfnrarh 635 10 pathogen pathogen NN cord-345222-otfnrarh 635 11 most most RBS cord-345222-otfnrarh 635 12 commonly commonly RB cord-345222-otfnrarh 635 13 treated treat VBN cord-345222-otfnrarh 635 14 with with IN cord-345222-otfnrarh 635 15 metronidazole metronidazole NNP cord-345222-otfnrarh 635 16 ( ( -LRB- cord-345222-otfnrarh 635 17 MTZ MTZ NNP cord-345222-otfnrarh 635 18 ) ) -RRB- cord-345222-otfnrarh 635 19 or or CC cord-345222-otfnrarh 635 20 tinidazole tinidazole NNP cord-345222-otfnrarh 635 21 submit submit VBP cord-345222-otfnrarh 635 22 your -PRON- PRP$ cord-345222-otfnrarh 635 23 manuscript manuscript NN cord-345222-otfnrarh 635 24 | | POS cord-345222-otfnrarh 635 25 www.dovepress.com www.dovepress.com ADD cord-345222-otfnrarh 636 1 Dovepress Dovepress NNP cord-345222-otfnrarh 636 2 Dovepress Dovepress NNP cord-345222-otfnrarh 636 3 but but CC cord-345222-otfnrarh 636 4 failures failure NNS cord-345222-otfnrarh 636 5 occur occur VBP cord-345222-otfnrarh 636 6 in in IN cord-345222-otfnrarh 636 7 10%-20 10%-20 CD cord-345222-otfnrarh 636 8 % % NN cord-345222-otfnrarh 636 9 of of IN cord-345222-otfnrarh 636 10 cases case NNS cord-345222-otfnrarh 636 11 . . . cord-345222-otfnrarh 637 1 Albendazole Albendazole NNP cord-345222-otfnrarh 637 2 may may MD cord-345222-otfnrarh 637 3 be be VB cord-345222-otfnrarh 637 4 of of IN cord-345222-otfnrarh 637 5 similar similar JJ cord-345222-otfnrarh 637 6 effectiveness effectiveness NN cord-345222-otfnrarh 637 7 to to IN cord-345222-otfnrarh 637 8 metronidazole metronidazole NNP cord-345222-otfnrarh 637 9 , , , cord-345222-otfnrarh 637 10 may may MD cord-345222-otfnrarh 637 11 have have VB cord-345222-otfnrarh 637 12 fewer few JJR cord-345222-otfnrarh 637 13 side side NN cord-345222-otfnrarh 637 14 effects effect NNS cord-345222-otfnrarh 637 15 , , , cord-345222-otfnrarh 637 16 and and CC cord-345222-otfnrarh 637 17 has have VBZ cord-345222-otfnrarh 637 18 the the DT cord-345222-otfnrarh 637 19 advantage advantage NN cord-345222-otfnrarh 637 20 of of IN cord-345222-otfnrarh 637 21 a a DT cord-345222-otfnrarh 637 22 simplified simplified JJ cord-345222-otfnrarh 637 23 regimen regimen NN cord-345222-otfnrarh 637 24 . . . cord-345222-otfnrarh 638 1 Nitazoxanide Nitazoxanide NNP cord-345222-otfnrarh 638 2 is be VBZ cord-345222-otfnrarh 638 3 a a DT cord-345222-otfnrarh 638 4 viable viable JJ cord-345222-otfnrarh 638 5 therapeutic therapeutic JJ cord-345222-otfnrarh 638 6 option option NN cord-345222-otfnrarh 638 7 as as IN cord-345222-otfnrarh 638 8 an an DT cord-345222-otfnrarh 638 9 effective effective JJ cord-345222-otfnrarh 638 10 alternative alternative NN cord-345222-otfnrarh 638 11 to to IN cord-345222-otfnrarh 638 12 MTZ MTZ NNP cord-345222-otfnrarh 638 13 in in IN cord-345222-otfnrarh 638 14 reducing reduce VBG cord-345222-otfnrarh 638 15 the the DT cord-345222-otfnrarh 638 16 duration duration NN cord-345222-otfnrarh 638 17 of of IN cord-345222-otfnrarh 638 18 diarrhea diarrhea NN cord-345222-otfnrarh 638 19 . . . cord-345222-otfnrarh 639 1 61 61 CD cord-345222-otfnrarh 639 2 , , , cord-345222-otfnrarh 639 3 188 188 CD cord-345222-otfnrarh 639 4 , , , cord-345222-otfnrarh 639 5 189 189 CD cord-345222-otfnrarh 639 6 Auranofin Auranofin NNP cord-345222-otfnrarh 639 7 , , , cord-345222-otfnrarh 639 8 a a DT cord-345222-otfnrarh 639 9 gold gold NN cord-345222-otfnrarh 639 10 complex complex NN cord-345222-otfnrarh 639 11 classified classify VBN cord-345222-otfnrarh 639 12 by by IN cord-345222-otfnrarh 639 13 the the DT cord-345222-otfnrarh 639 14 WHO WHO NNP cord-345222-otfnrarh 639 15 as as IN cord-345222-otfnrarh 639 16 an an DT cord-345222-otfnrarh 639 17 antirheumatic antirheumatic JJ cord-345222-otfnrarh 639 18 agent agent NN cord-345222-otfnrarh 639 19 , , , cord-345222-otfnrarh 639 20 has have VBZ cord-345222-otfnrarh 639 21 been be VBN cord-345222-otfnrarh 639 22 revealed reveal VBN cord-345222-otfnrarh 639 23 to to TO cord-345222-otfnrarh 639 24 be be VB cord-345222-otfnrarh 639 25 active active JJ cord-345222-otfnrarh 639 26 against against IN cord-345222-otfnrarh 639 27 multiple multiple JJ cord-345222-otfnrarh 639 28 MTZ MTZ NNP cord-345222-otfnrarh 639 29 - - HYPH cord-345222-otfnrarh 639 30 resistant resistant JJ cord-345222-otfnrarh 639 31 strains strain NNS cord-345222-otfnrarh 639 32 blocking block VBG cord-345222-otfnrarh 639 33 a a DT cord-345222-otfnrarh 639 34 critical critical JJ cord-345222-otfnrarh 639 35 enzyme enzyme NN cord-345222-otfnrarh 639 36 involved involve VBN cord-345222-otfnrarh 639 37 in in IN cord-345222-otfnrarh 639 38 maintaining maintain VBG cord-345222-otfnrarh 639 39 normal normal JJ cord-345222-otfnrarh 639 40 protein protein NN cord-345222-otfnrarh 639 41 function function NN cord-345222-otfnrarh 639 42 . . . cord-345222-otfnrarh 640 1 These these DT cord-345222-otfnrarh 640 2 results result NNS cord-345222-otfnrarh 640 3 indicate indicate VBP cord-345222-otfnrarh 640 4 that that IN cord-345222-otfnrarh 640 5 auranofin auranofin NNP cord-345222-otfnrarh 640 6 could could MD cord-345222-otfnrarh 640 7 be be VB cord-345222-otfnrarh 640 8 developed develop VBN cord-345222-otfnrarh 640 9 as as IN cord-345222-otfnrarh 640 10 an an DT cord-345222-otfnrarh 640 11 antigiardial antigiardial JJ cord-345222-otfnrarh 640 12 drug drug NN cord-345222-otfnrarh 640 13 , , , cord-345222-otfnrarh 640 14 particularly particularly RB cord-345222-otfnrarh 640 15 against against IN cord-345222-otfnrarh 640 16 MTZ MTZ NNP cord-345222-otfnrarh 640 17 - - HYPH cord-345222-otfnrarh 640 18 resistant resistant JJ cord-345222-otfnrarh 640 19 strains strain NNS cord-345222-otfnrarh 640 20 . . . cord-345222-otfnrarh 641 1 190 190 CD cord-345222-otfnrarh 641 2 Entamoeba Entamoeba NNP cord-345222-otfnrarh 641 3 histolytica histolytica NNP cord-345222-otfnrarh 641 4 amebiasis amebiasis NN cord-345222-otfnrarh 641 5 is be VBZ cord-345222-otfnrarh 641 6 the the DT cord-345222-otfnrarh 641 7 fourth fourth RB cord-345222-otfnrarh 641 8 - - HYPH cord-345222-otfnrarh 641 9 leading lead VBG cord-345222-otfnrarh 641 10 cause cause NN cord-345222-otfnrarh 641 11 of of IN cord-345222-otfnrarh 641 12 death death NN cord-345222-otfnrarh 641 13 and and CC cord-345222-otfnrarh 641 14 the the DT cord-345222-otfnrarh 641 15 third third RB cord-345222-otfnrarh 641 16 - - HYPH cord-345222-otfnrarh 641 17 leading lead VBG cord-345222-otfnrarh 641 18 cause cause NN cord-345222-otfnrarh 641 19 of of IN cord-345222-otfnrarh 641 20 morbidity morbidity NN cord-345222-otfnrarh 641 21 due due IN cord-345222-otfnrarh 641 22 to to IN cord-345222-otfnrarh 641 23 protozoan protozoan NN cord-345222-otfnrarh 641 24 infections infection NNS cord-345222-otfnrarh 641 25 worldwide worldwide RB cord-345222-otfnrarh 641 26 . . . cord-345222-otfnrarh 642 1 In in IN cord-345222-otfnrarh 642 2 children child NNS cord-345222-otfnrarh 642 3 , , , cord-345222-otfnrarh 642 4 effective effective JJ cord-345222-otfnrarh 642 5 drugs drug NNS cord-345222-otfnrarh 642 6 for for IN cord-345222-otfnrarh 642 7 diarrhea diarrhea NN cord-345222-otfnrarh 642 8 are be VBP cord-345222-otfnrarh 642 9 MTZ MTZ NNP cord-345222-otfnrarh 642 10 and and CC cord-345222-otfnrarh 642 11 other other JJ cord-345222-otfnrarh 642 12 nitroimidazoles nitroimidazole NNS cord-345222-otfnrarh 642 13 . . . cord-345222-otfnrarh 643 1 However however RB cord-345222-otfnrarh 643 2 , , , cord-345222-otfnrarh 643 3 eradication eradication NN cord-345222-otfnrarh 643 4 of of IN cord-345222-otfnrarh 643 5 E. E. NNP cord-345222-otfnrarh 643 6 histolytica histolytica NNP cord-345222-otfnrarh 643 7 infection infection NN cord-345222-otfnrarh 643 8 after after IN cord-345222-otfnrarh 643 9 completion completion NN cord-345222-otfnrarh 643 10 of of IN cord-345222-otfnrarh 643 11 MTZ MTZ NNP cord-345222-otfnrarh 643 12 requires require VBZ cord-345222-otfnrarh 643 13 additional additional JJ cord-345222-otfnrarh 643 14 therapy therapy NN cord-345222-otfnrarh 643 15 with with IN cord-345222-otfnrarh 643 16 luminal luminal JJ cord-345222-otfnrarh 643 17 amebicides amebicide NNS cord-345222-otfnrarh 643 18 , , , cord-345222-otfnrarh 643 19 such such JJ cord-345222-otfnrarh 643 20 as as IN cord-345222-otfnrarh 643 21 paramomycin paramomycin NNS cord-345222-otfnrarh 643 22 . . . cord-345222-otfnrarh 644 1 Nitazoxanide Nitazoxanide NNP cord-345222-otfnrarh 644 2 is be VBZ cord-345222-otfnrarh 644 3 a a DT cord-345222-otfnrarh 644 4 recent recent JJ cord-345222-otfnrarh 644 5 therapeutic therapeutic JJ cord-345222-otfnrarh 644 6 advance advance NN cord-345222-otfnrarh 644 7 , , , cord-345222-otfnrarh 644 8 due due IN cord-345222-otfnrarh 644 9 to to IN cord-345222-otfnrarh 644 10 its -PRON- PRP$ cord-345222-otfnrarh 644 11 action action NN cord-345222-otfnrarh 644 12 against against IN cord-345222-otfnrarh 644 13 luminal luminal JJ cord-345222-otfnrarh 644 14 and and CC cord-345222-otfnrarh 644 15 invasive invasive JJ cord-345222-otfnrarh 644 16 parasite parasite NN cord-345222-otfnrarh 644 17 forms form NNS cord-345222-otfnrarh 644 18 . . . cord-345222-otfnrarh 645 1 191 191 CD cord-345222-otfnrarh 645 2 Nitazoxanide Nitazoxanide NNP cord-345222-otfnrarh 645 3 - - HYPH cord-345222-otfnrarh 645 4 treated treat VBN cord-345222-otfnrarh 645 5 patients patient NNS cord-345222-otfnrarh 645 6 had have VBD cord-345222-otfnrarh 645 7 statistically statistically RB cord-345222-otfnrarh 645 8 shorter short JJR cord-345222-otfnrarh 645 9 durations duration NNS cord-345222-otfnrarh 645 10 of of IN cord-345222-otfnrarh 645 11 diarrheal diarrheal JJ cord-345222-otfnrarh 645 12 illness illness NN cord-345222-otfnrarh 645 13 . . . cord-345222-otfnrarh 646 1 Auranofin Auranofin NNP cord-345222-otfnrarh 646 2 could could MD cord-345222-otfnrarh 646 3 represent represent VB cord-345222-otfnrarh 646 4 a a DT cord-345222-otfnrarh 646 5 promising promising JJ cord-345222-otfnrarh 646 6 therapy therapy NN cord-345222-otfnrarh 646 7 for for IN cord-345222-otfnrarh 646 8 amebiasis amebiasis NNP cord-345222-otfnrarh 646 9 . . . cord-345222-otfnrarh 647 1 187 187 CD cord-345222-otfnrarh 647 2 Parasitic parasitic JJ cord-345222-otfnrarh 647 3 -helminths -helminth NNS cord-345222-otfnrarh 647 4 nematodes nematode NNS cord-345222-otfnrarh 647 5 Strongyloides Strongyloides NNP cord-345222-otfnrarh 647 6 stercoralis stercoralis NNP cord-345222-otfnrarh 647 7 and and CC cord-345222-otfnrarh 647 8 Trichuris Trichuris NNP cord-345222-otfnrarh 647 9 trichiura trichiura NN cord-345222-otfnrarh 647 10 are be VBP cord-345222-otfnrarh 647 11 causes cause NNS cord-345222-otfnrarh 647 12 of of IN cord-345222-otfnrarh 647 13 diarrhea diarrhea NN cord-345222-otfnrarh 647 14 . . . cord-345222-otfnrarh 648 1 Strongyloides Strongyloides NNP cord-345222-otfnrarh 648 2 stercoralis stercoralis NNP cord-345222-otfnrarh 648 3 can can MD cord-345222-otfnrarh 648 4 penetrate penetrate VB cord-345222-otfnrarh 648 5 host host NN cord-345222-otfnrarh 648 6 skin skin NN cord-345222-otfnrarh 648 7 and and CC cord-345222-otfnrarh 648 8 parasitize parasitize VB cord-345222-otfnrarh 648 9 human human JJ cord-345222-otfnrarh 648 10 intestines intestine NNS cord-345222-otfnrarh 648 11 , , , cord-345222-otfnrarh 648 12 leading lead VBG cord-345222-otfnrarh 648 13 to to IN cord-345222-otfnrarh 648 14 burning burn VBG cord-345222-otfnrarh 648 15 pain pain NN cord-345222-otfnrarh 648 16 , , , cord-345222-otfnrarh 648 17 tissue tissue NN cord-345222-otfnrarh 648 18 damage damage NN cord-345222-otfnrarh 648 19 , , , cord-345222-otfnrarh 648 20 ulcers ulcer NNS cord-345222-otfnrarh 648 21 , , , cord-345222-otfnrarh 648 22 edema edema NN cord-345222-otfnrarh 648 23 and and CC cord-345222-otfnrarh 648 24 obstruction obstruction NN cord-345222-otfnrarh 648 25 of of IN cord-345222-otfnrarh 648 26 the the DT cord-345222-otfnrarh 648 27 intestinal intestinal JJ cord-345222-otfnrarh 648 28 tract tract NN cord-345222-otfnrarh 648 29 , , , cord-345222-otfnrarh 648 30 and and CC cord-345222-otfnrarh 648 31 diarrhea diarrhea NN cord-345222-otfnrarh 648 32 , , , cord-345222-otfnrarh 648 33 as as RB cord-345222-otfnrarh 648 34 well well RB cord-345222-otfnrarh 648 35 as as IN cord-345222-otfnrarh 648 36 loss loss NN cord-345222-otfnrarh 648 37 of of IN cord-345222-otfnrarh 648 38 peristaltic peristaltic JJ cord-345222-otfnrarh 648 39 contractions contraction NNS cord-345222-otfnrarh 648 40 . . . cord-345222-otfnrarh 649 1 Ivermectin Ivermectin NNP cord-345222-otfnrarh 649 2 is be VBZ cord-345222-otfnrarh 649 3 the the DT cord-345222-otfnrarh 649 4 first first JJ cord-345222-otfnrarh 649 5 - - HYPH cord-345222-otfnrarh 649 6 choice choice NN cord-345222-otfnrarh 649 7 therapy therapy NN cord-345222-otfnrarh 649 8 because because IN cord-345222-otfnrarh 649 9 of of IN cord-345222-otfnrarh 649 10 its -PRON- PRP$ cord-345222-otfnrarh 649 11 higher high JJR cord-345222-otfnrarh 649 12 tolerance tolerance NN cord-345222-otfnrarh 649 13 , , , cord-345222-otfnrarh 649 14 and and CC cord-345222-otfnrarh 649 15 albendazole albendazole NN cord-345222-otfnrarh 649 16 is be VBZ cord-345222-otfnrarh 649 17 the the DT cord-345222-otfnrarh 649 18 second second JJ cord-345222-otfnrarh 649 19 - - HYPH cord-345222-otfnrarh 649 20 choice choice NN cord-345222-otfnrarh 649 21 therapy therapy NN cord-345222-otfnrarh 649 22 . . . cord-345222-otfnrarh 650 1 61 61 CD cord-345222-otfnrarh 650 2 , , , cord-345222-otfnrarh 650 3 192 192 CD cord-345222-otfnrarh 650 4 Trichuris Trichuris NNP cord-345222-otfnrarh 650 5 trichiura trichiura NN cord-345222-otfnrarh 650 6 is be VBZ cord-345222-otfnrarh 650 7 chiefly chiefly RB cord-345222-otfnrarh 650 8 a a DT cord-345222-otfnrarh 650 9 tropical tropical JJ cord-345222-otfnrarh 650 10 infection infection NN cord-345222-otfnrarh 650 11 , , , cord-345222-otfnrarh 650 12 and and CC cord-345222-otfnrarh 650 13 children child NNS cord-345222-otfnrarh 650 14 are be VBP cord-345222-otfnrarh 650 15 especially especially RB cord-345222-otfnrarh 650 16 vulnerable vulnerable JJ cord-345222-otfnrarh 650 17 to to IN cord-345222-otfnrarh 650 18 infection infection NN cord-345222-otfnrarh 650 19 due due IN cord-345222-otfnrarh 650 20 to to IN cord-345222-otfnrarh 650 21 their -PRON- PRP$ cord-345222-otfnrarh 650 22 high high JJ cord-345222-otfnrarh 650 23 exposure exposure NN cord-345222-otfnrarh 650 24 risk risk NN cord-345222-otfnrarh 650 25 . . . cord-345222-otfnrarh 651 1 Light light JJ cord-345222-otfnrarh 651 2 infestations infestation NNS cord-345222-otfnrarh 651 3 ( ( -LRB- cord-345222-otfnrarh 651 4 , , , cord-345222-otfnrarh 651 5 100 100 CD cord-345222-otfnrarh 651 6 worms worm NNS cord-345222-otfnrarh 651 7 ) ) -RRB- cord-345222-otfnrarh 651 8 are be VBP cord-345222-otfnrarh 651 9 frequently frequently RB cord-345222-otfnrarh 651 10 asymptomatic asymptomatic JJ cord-345222-otfnrarh 651 11 , , , cord-345222-otfnrarh 651 12 but but CC cord-345222-otfnrarh 651 13 heavy heavy JJ cord-345222-otfnrarh 651 14 infestations infestation NNS cord-345222-otfnrarh 651 15 may may MD cord-345222-otfnrarh 651 16 cause cause VB cord-345222-otfnrarh 651 17 mechanical mechanical JJ cord-345222-otfnrarh 651 18 or or CC cord-345222-otfnrarh 651 19 inflammatory inflammatory JJ cord-345222-otfnrarh 651 20 damage damage NN cord-345222-otfnrarh 651 21 to to IN cord-345222-otfnrarh 651 22 the the DT cord-345222-otfnrarh 651 23 mucosa mucosa JJ cord-345222-otfnrarh 651 24 , , , cord-345222-otfnrarh 651 25 abdominal abdominal JJ cord-345222-otfnrarh 651 26 pain pain NN cord-345222-otfnrarh 651 27 , , , cord-345222-otfnrarh 651 28 profuse profuse JJ cord-345222-otfnrarh 651 29 or or CC cord-345222-otfnrarh 651 30 chronic chronic JJ cord-345222-otfnrarh 651 31 diarrhea diarrhea NN cord-345222-otfnrarh 651 32 , , , cord-345222-otfnrarh 651 33 and and CC cord-345222-otfnrarh 651 34 bloody bloody JJ cord-345222-otfnrarh 651 35 diarrhea diarrhea NN cord-345222-otfnrarh 651 36 . . . cord-345222-otfnrarh 652 1 Mebendazole Mebendazole NNP cord-345222-otfnrarh 652 2 seems seem VBZ cord-345222-otfnrarh 652 3 to to TO cord-345222-otfnrarh 652 4 be be VB cord-345222-otfnrarh 652 5 the the DT cord-345222-otfnrarh 652 6 first first JJ cord-345222-otfnrarh 652 7 - - HYPH cord-345222-otfnrarh 652 8 choice choice NN cord-345222-otfnrarh 652 9 therapy therapy NN cord-345222-otfnrarh 652 10 and and CC cord-345222-otfnrarh 652 11 albendazole albendazole RB cord-345222-otfnrarh 652 12 the the DT cord-345222-otfnrarh 652 13 second second JJ cord-345222-otfnrarh 652 14 - - HYPH cord-345222-otfnrarh 652 15 choice choice NN cord-345222-otfnrarh 652 16 therapy therapy NN cord-345222-otfnrarh 652 17 , , , cord-345222-otfnrarh 652 18 while while IN cord-345222-otfnrarh 652 19 nitazoxanide nitazoxanide NNP cord-345222-otfnrarh 652 20 shows show VBZ cord-345222-otfnrarh 652 21 no no DT cord-345222-otfnrarh 652 22 effect effect NN cord-345222-otfnrarh 652 23 . . . cord-345222-otfnrarh 653 1 An an DT cord-345222-otfnrarh 653 2 albendazole albendazole NN cord-345222-otfnrarh 653 3 and and CC cord-345222-otfnrarh 653 4 nitazoxanide nitazoxanide JJ cord-345222-otfnrarh 653 5 - - HYPH cord-345222-otfnrarh 653 6 albendazole albendazole NN cord-345222-otfnrarh 653 7 combination combination NN cord-345222-otfnrarh 653 8 showed show VBD cord-345222-otfnrarh 653 9 only only RB cord-345222-otfnrarh 653 10 a a DT cord-345222-otfnrarh 653 11 minimal minimal JJ cord-345222-otfnrarh 653 12 effect effect NN cord-345222-otfnrarh 653 13 . . . cord-345222-otfnrarh 654 1 There there EX cord-345222-otfnrarh 654 2 is be VBZ cord-345222-otfnrarh 654 3 a a DT cord-345222-otfnrarh 654 4 need need NN cord-345222-otfnrarh 654 5 to to TO cord-345222-otfnrarh 654 6 develop develop VB cord-345222-otfnrarh 654 7 new new JJ cord-345222-otfnrarh 654 8 anthelmintics anthelmintic NNS cord-345222-otfnrarh 654 9 against against IN cord-345222-otfnrarh 654 10 trichuriasis trichuriasis NNP cord-345222-otfnrarh 654 11 . . . cord-345222-otfnrarh 655 1 193 193 CD cord-345222-otfnrarh 655 2 AGE age NN cord-345222-otfnrarh 655 3 remains remain VBZ cord-345222-otfnrarh 655 4 a a DT cord-345222-otfnrarh 655 5 major major JJ cord-345222-otfnrarh 655 6 problem problem NN cord-345222-otfnrarh 655 7 in in IN cord-345222-otfnrarh 655 8 children child NNS cord-345222-otfnrarh 655 9 and and CC cord-345222-otfnrarh 655 10 still still RB cord-345222-otfnrarh 655 11 represents represent VBZ cord-345222-otfnrarh 655 12 one one CD cord-345222-otfnrarh 655 13 of of IN cord-345222-otfnrarh 655 14 the the DT cord-345222-otfnrarh 655 15 leading lead VBG cord-345222-otfnrarh 655 16 causes cause NNS cord-345222-otfnrarh 655 17 of of IN cord-345222-otfnrarh 655 18 illness illness NN cord-345222-otfnrarh 655 19 costs cost NNS cord-345222-otfnrarh 655 20 and and CC cord-345222-otfnrarh 655 21 of of IN cord-345222-otfnrarh 655 22 deaths death NNS cord-345222-otfnrarh 655 23 , , , cord-345222-otfnrarh 655 24 as as IN cord-345222-otfnrarh 655 25 an an DT cord-345222-otfnrarh 655 26 estimated estimate VBN cord-345222-otfnrarh 655 27 2.5 2.5 CD cord-345222-otfnrarh 655 28 million million CD cord-345222-otfnrarh 655 29 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 655 30 deaths death NNS cord-345222-otfnrarh 655 31 occur occur VBP cord-345222-otfnrarh 655 32 each each DT cord-345222-otfnrarh 655 33 year year NN cord-345222-otfnrarh 655 34 in in IN cord-345222-otfnrarh 655 35 children child NNS cord-345222-otfnrarh 655 36 less less JJR cord-345222-otfnrarh 655 37 than than IN cord-345222-otfnrarh 655 38 5 5 CD cord-345222-otfnrarh 655 39 years year NNS cord-345222-otfnrarh 655 40 of of IN cord-345222-otfnrarh 655 41 age age NN cord-345222-otfnrarh 655 42 throughout throughout IN cord-345222-otfnrarh 655 43 the the DT cord-345222-otfnrarh 655 44 world world NN cord-345222-otfnrarh 655 45 , , , cord-345222-otfnrarh 655 46 especially especially RB cord-345222-otfnrarh 655 47 in in IN cord-345222-otfnrarh 655 48 resource resource NN cord-345222-otfnrarh 655 49 - - HYPH cord-345222-otfnrarh 655 50 constrained constrain VBN cord-345222-otfnrarh 655 51 countries country NNS cord-345222-otfnrarh 655 52 . . . cord-345222-otfnrarh 656 1 In in IN cord-345222-otfnrarh 656 2 rich rich JJ cord-345222-otfnrarh 656 3 countries country NNS cord-345222-otfnrarh 656 4 , , , cord-345222-otfnrarh 656 5 transmission transmission NN cord-345222-otfnrarh 656 6 occurs occur VBZ cord-345222-otfnrarh 656 7 much much RB cord-345222-otfnrarh 656 8 more more RBR cord-345222-otfnrarh 656 9 frequently frequently RB cord-345222-otfnrarh 656 10 from from IN cord-345222-otfnrarh 656 11 contaminated contaminate VBN cord-345222-otfnrarh 656 12 food food NN cord-345222-otfnrarh 656 13 compared compare VBN cord-345222-otfnrarh 656 14 to to IN cord-345222-otfnrarh 656 15 direct direct JJ cord-345222-otfnrarh 656 16 person person NN cord-345222-otfnrarh 656 17 - - HYPH cord-345222-otfnrarh 656 18 to to IN cord-345222-otfnrarh 656 19 - - HYPH cord-345222-otfnrarh 656 20 person person NN cord-345222-otfnrarh 656 21 contact contact NN cord-345222-otfnrarh 656 22 , , , cord-345222-otfnrarh 656 23 except except IN cord-345222-otfnrarh 656 24 for for IN cord-345222-otfnrarh 656 25 enteric enteric JJ cord-345222-otfnrarh 656 26 viruses virus NNS cord-345222-otfnrarh 656 27 , , , cord-345222-otfnrarh 656 28 which which WDT cord-345222-otfnrarh 656 29 can can MD cord-345222-otfnrarh 656 30 also also RB cord-345222-otfnrarh 656 31 be be VB cord-345222-otfnrarh 656 32 transmitted transmit VBN cord-345222-otfnrarh 656 33 by by IN cord-345222-otfnrarh 656 34 aerosol aerosol NN cord-345222-otfnrarh 656 35 formation formation NN cord-345222-otfnrarh 656 36 after after IN cord-345222-otfnrarh 656 37 vomiting vomit VBG cord-345222-otfnrarh 656 38 . . . cord-345222-otfnrarh 657 1 Most Most JJS cord-345222-otfnrarh 657 2 cases case NNS cord-345222-otfnrarh 657 3 of of IN cord-345222-otfnrarh 657 4 AGE age NN cord-345222-otfnrarh 657 5 in in IN cord-345222-otfnrarh 657 6 children child NNS cord-345222-otfnrarh 657 7 are be VBP cord-345222-otfnrarh 657 8 viral viral JJ cord-345222-otfnrarh 657 9 , , , cord-345222-otfnrarh 657 10 self self NN cord-345222-otfnrarh 657 11 - - HYPH cord-345222-otfnrarh 657 12 limited limit VBN cord-345222-otfnrarh 657 13 , , , cord-345222-otfnrarh 657 14 and and CC cord-345222-otfnrarh 657 15 need need VBP cord-345222-otfnrarh 657 16 only only RB cord-345222-otfnrarh 657 17 supportive supportive JJ cord-345222-otfnrarh 657 18 treatment treatment NN cord-345222-otfnrarh 657 19 . . . cord-345222-otfnrarh 658 1 Rehydration rehydration NN cord-345222-otfnrarh 658 2 ( ( -LRB- cord-345222-otfnrarh 658 3 oral oral JJ cord-345222-otfnrarh 658 4 or or CC cord-345222-otfnrarh 658 5 intravenous intravenous JJ cord-345222-otfnrarh 658 6 ) ) -RRB- cord-345222-otfnrarh 658 7 with with IN cord-345222-otfnrarh 658 8 an an DT cord-345222-otfnrarh 658 9 appropriate appropriate JJ cord-345222-otfnrarh 658 10 fluid fluid NN cord-345222-otfnrarh 658 11 - - HYPH cord-345222-otfnrarh 658 12 and and CC cord-345222-otfnrarh 658 13 - - HYPH cord-345222-otfnrarh 658 14 electrolyte electrolyte JJ cord-345222-otfnrarh 658 15 balance balance NN cord-345222-otfnrarh 658 16 , , , cord-345222-otfnrarh 658 17 with with IN cord-345222-otfnrarh 658 18 close close JJ cord-345222-otfnrarh 658 19 attention attention NN cord-345222-otfnrarh 658 20 to to IN cord-345222-otfnrarh 658 21 nutrition nutrition NN cord-345222-otfnrarh 658 22 , , , cord-345222-otfnrarh 658 23 remains remain VBZ cord-345222-otfnrarh 658 24 central central JJ cord-345222-otfnrarh 658 25 to to IN cord-345222-otfnrarh 658 26 therapy therapy NN cord-345222-otfnrarh 658 27 : : : cord-345222-otfnrarh 658 28 this this DT cord-345222-otfnrarh 658 29 may may MD cord-345222-otfnrarh 658 30 turn turn VB cord-345222-otfnrarh 658 31 into into IN cord-345222-otfnrarh 658 32 an an DT cord-345222-otfnrarh 658 33 additional additional JJ cord-345222-otfnrarh 658 34 benefit benefit NN cord-345222-otfnrarh 658 35 in in IN cord-345222-otfnrarh 658 36 limiting limit VBG cord-345222-otfnrarh 658 37 hospitalizations hospitalization NNS cord-345222-otfnrarh 658 38 . . . cord-345222-otfnrarh 659 1 Intestinal intestinal JJ cord-345222-otfnrarh 659 2 infections infection NNS cord-345222-otfnrarh 659 3 often often RB cord-345222-otfnrarh 659 4 require require VBP cord-345222-otfnrarh 659 5 drugs drug NNS cord-345222-otfnrarh 659 6 such such JJ cord-345222-otfnrarh 659 7 as as IN cord-345222-otfnrarh 659 8 antiemetics antiemetic NNS cord-345222-otfnrarh 659 9 , , , cord-345222-otfnrarh 659 10 antidiarrheal antidiarrheal JJ cord-345222-otfnrarh 659 11 agents agent NNS cord-345222-otfnrarh 659 12 , , , cord-345222-otfnrarh 659 13 and and CC cord-345222-otfnrarh 659 14 probiotics probiotic NNS cord-345222-otfnrarh 659 15 that that WDT cord-345222-otfnrarh 659 16 may may MD cord-345222-otfnrarh 659 17 deeply deeply RB cord-345222-otfnrarh 659 18 change change VB cord-345222-otfnrarh 659 19 the the DT cord-345222-otfnrarh 659 20 impact impact NN cord-345222-otfnrarh 659 21 , , , cord-345222-otfnrarh 659 22 severity severity NN cord-345222-otfnrarh 659 23 , , , cord-345222-otfnrarh 659 24 and and CC cord-345222-otfnrarh 659 25 duration duration NN cord-345222-otfnrarh 659 26 of of IN cord-345222-otfnrarh 659 27 acute acute JJ cord-345222-otfnrarh 659 28 diarrhea diarrhea NN cord-345222-otfnrarh 659 29 . . . cord-345222-otfnrarh 660 1 In in IN cord-345222-otfnrarh 660 2 cases case NNS cord-345222-otfnrarh 660 3 of of IN cord-345222-otfnrarh 660 4 severe severe JJ cord-345222-otfnrarh 660 5 infectious infectious JJ cord-345222-otfnrarh 660 6 diarrhea diarrhea NN cord-345222-otfnrarh 660 7 with with IN cord-345222-otfnrarh 660 8 a a DT cord-345222-otfnrarh 660 9 prolonged prolonged JJ cord-345222-otfnrarh 660 10 course course NN cord-345222-otfnrarh 660 11 , , , cord-345222-otfnrarh 660 12 signs sign NNS cord-345222-otfnrarh 660 13 of of IN cord-345222-otfnrarh 660 14 inflammation inflammation NN cord-345222-otfnrarh 660 15 , , , cord-345222-otfnrarh 660 16 bloody bloody JJ cord-345222-otfnrarh 660 17 stool stool NN cord-345222-otfnrarh 660 18 , , , cord-345222-otfnrarh 660 19 immunosuppression immunosuppression NN cord-345222-otfnrarh 660 20 , , , cord-345222-otfnrarh 660 21 and and CC cord-345222-otfnrarh 660 22 comorbidity comorbidity NN cord-345222-otfnrarh 660 23 , , , cord-345222-otfnrarh 660 24 and and CC cord-345222-otfnrarh 660 25 in in IN cord-345222-otfnrarh 660 26 suspected suspect VBN cord-345222-otfnrarh 660 27 outbreaks outbreak NNS cord-345222-otfnrarh 660 28 , , , cord-345222-otfnrarh 660 29 fecal fecal JJ cord-345222-otfnrarh 660 30 microbial microbial JJ cord-345222-otfnrarh 660 31 analysis analysis NN cord-345222-otfnrarh 660 32 , , , cord-345222-otfnrarh 660 33 should should MD cord-345222-otfnrarh 660 34 always always RB cord-345222-otfnrarh 660 35 be be VB cord-345222-otfnrarh 660 36 performed perform VBN cord-345222-otfnrarh 660 37 , , , cord-345222-otfnrarh 660 38 and and CC cord-345222-otfnrarh 660 39 a a DT cord-345222-otfnrarh 660 40 specific specific JJ cord-345222-otfnrarh 660 41 therapy therapy NN cord-345222-otfnrarh 660 42 should should MD cord-345222-otfnrarh 660 43 be be VB cord-345222-otfnrarh 660 44 considered consider VBN cord-345222-otfnrarh 660 45 if if IN cord-345222-otfnrarh 660 46 indicated indicate VBN cord-345222-otfnrarh 660 47 to to TO cord-345222-otfnrarh 660 48 shorten shorten VB cord-345222-otfnrarh 660 49 the the DT cord-345222-otfnrarh 660 50 clinical clinical JJ cord-345222-otfnrarh 660 51 course course NN cord-345222-otfnrarh 660 52 , , , cord-345222-otfnrarh 660 53 eradicate eradicate VB cord-345222-otfnrarh 660 54 causative causative JJ cord-345222-otfnrarh 660 55 organisms organism NNS cord-345222-otfnrarh 660 56 , , , cord-345222-otfnrarh 660 57 reduce reduce VB cord-345222-otfnrarh 660 58 transmission transmission NN cord-345222-otfnrarh 660 59 , , , cord-345222-otfnrarh 660 60 and and CC cord-345222-otfnrarh 660 61 prevent prevent VB cord-345222-otfnrarh 660 62 invasive invasive JJ cord-345222-otfnrarh 660 63 complications complication NNS cord-345222-otfnrarh 660 64 . . . cord-345222-otfnrarh 661 1 Selection selection NN cord-345222-otfnrarh 661 2 of of IN cord-345222-otfnrarh 661 3 antibacterials antibacterial NNS cord-345222-otfnrarh 661 4 to to TO cord-345222-otfnrarh 661 5 use use VB cord-345222-otfnrarh 661 6 in in IN cord-345222-otfnrarh 661 7 acute acute JJ cord-345222-otfnrarh 661 8 bacterial bacterial JJ cord-345222-otfnrarh 661 9 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 661 10 is be VBZ cord-345222-otfnrarh 661 11 based base VBN cord-345222-otfnrarh 661 12 on on IN cord-345222-otfnrarh 661 13 clinical clinical JJ cord-345222-otfnrarh 661 14 diagnosis diagnosis NN cord-345222-otfnrarh 661 15 of of IN cord-345222-otfnrarh 661 16 the the DT cord-345222-otfnrarh 661 17 likely likely JJ cord-345222-otfnrarh 661 18 pathogen pathogen NN cord-345222-otfnrarh 661 19 and and CC cord-345222-otfnrarh 661 20 on on IN cord-345222-otfnrarh 661 21 definitive definitive JJ cord-345222-otfnrarh 661 22 laboratory laboratory NN cord-345222-otfnrarh 661 23 results result NNS cord-345222-otfnrarh 661 24 . . . cord-345222-otfnrarh 662 1 Based base VBN cord-345222-otfnrarh 662 2 on on IN cord-345222-otfnrarh 662 3 epidemiological epidemiological JJ cord-345222-otfnrarh 662 4 data datum NNS cord-345222-otfnrarh 662 5 and and CC cord-345222-otfnrarh 662 6 after after IN cord-345222-otfnrarh 662 7 collecting collect VBG cord-345222-otfnrarh 662 8 organic organic JJ cord-345222-otfnrarh 662 9 materials material NNS cord-345222-otfnrarh 662 10 for for IN cord-345222-otfnrarh 662 11 etiological etiological JJ cord-345222-otfnrarh 662 12 diagnosis diagnosis NN cord-345222-otfnrarh 662 13 ( ( -LRB- cord-345222-otfnrarh 662 14 often often RB cord-345222-otfnrarh 662 15 a a DT cord-345222-otfnrarh 662 16 single single JJ cord-345222-otfnrarh 662 17 fecal fecal JJ cord-345222-otfnrarh 662 18 sample sample NN cord-345222-otfnrarh 662 19 studied study VBN cord-345222-otfnrarh 662 20 for for IN cord-345222-otfnrarh 662 21 etiologic etiologic JJ cord-345222-otfnrarh 662 22 agents agent NNS cord-345222-otfnrarh 662 23 is be VBZ cord-345222-otfnrarh 662 24 the the DT cord-345222-otfnrarh 662 25 customary customary JJ cord-345222-otfnrarh 662 26 way way NN cord-345222-otfnrarh 662 27 to to TO cord-345222-otfnrarh 662 28 make make VB cord-345222-otfnrarh 662 29 an an DT cord-345222-otfnrarh 662 30 etiologic etiologic JJ cord-345222-otfnrarh 662 31 diagnosis diagnosis NN cord-345222-otfnrarh 662 32 ) ) -RRB- cord-345222-otfnrarh 662 33 , , , cord-345222-otfnrarh 662 34 an an DT cord-345222-otfnrarh 662 35 initial initial JJ cord-345222-otfnrarh 662 36 empiric empiric JJ cord-345222-otfnrarh 662 37 therapy therapy NN cord-345222-otfnrarh 662 38 may may MD cord-345222-otfnrarh 662 39 be be VB cord-345222-otfnrarh 662 40 appropriate appropriate JJ cord-345222-otfnrarh 662 41 in in IN cord-345222-otfnrarh 662 42 case case NN cord-345222-otfnrarh 662 43 of of IN cord-345222-otfnrarh 662 44 a a DT cord-345222-otfnrarh 662 45 severe severe JJ cord-345222-otfnrarh 662 46 illness illness NN cord-345222-otfnrarh 662 47 , , , cord-345222-otfnrarh 662 48 particularly particularly RB cord-345222-otfnrarh 662 49 in in IN cord-345222-otfnrarh 662 50 infancy infancy NN cord-345222-otfnrarh 662 51 and and CC cord-345222-otfnrarh 662 52 the the DT cord-345222-otfnrarh 662 53 immunocompromised immunocompromised JJ cord-345222-otfnrarh 662 54 . . . cord-345222-otfnrarh 663 1 In in IN cord-345222-otfnrarh 663 2 case case NN cord-345222-otfnrarh 663 3 of of IN cord-345222-otfnrarh 663 4 suspected suspect VBN cord-345222-otfnrarh 663 5 EHEC EHEC NNP cord-345222-otfnrarh 663 6 serotype serotype NN cord-345222-otfnrarh 663 7 O157 O157 NNP cord-345222-otfnrarh 663 8 and and CC cord-345222-otfnrarh 663 9 EAEC EAEC NNP cord-345222-otfnrarh 663 10 serotype serotype NN cord-345222-otfnrarh 663 11 O104 o104 NN cord-345222-otfnrarh 663 12 : : : cord-345222-otfnrarh 663 13 H4 h4 NN cord-345222-otfnrarh 663 14 ( ( -LRB- cord-345222-otfnrarh 663 15 but but CC cord-345222-otfnrarh 663 16 also also RB cord-345222-otfnrarh 663 17 of of IN cord-345222-otfnrarh 663 18 Shigella Shigella NNP cord-345222-otfnrarh 663 19 dysenteriae dysenteriae NN cord-345222-otfnrarh 663 20 serotype serotype NN cord-345222-otfnrarh 663 21 1 1 CD cord-345222-otfnrarh 663 22 ) ) -RRB- cord-345222-otfnrarh 663 23 , , , cord-345222-otfnrarh 663 24 as as IN cord-345222-otfnrarh 663 25 it -PRON- PRP cord-345222-otfnrarh 663 26 is be VBZ cord-345222-otfnrarh 663 27 estimated estimate VBN cord-345222-otfnrarh 663 28 that that IN cord-345222-otfnrarh 663 29 5%-8 5%-8 CD cord-345222-otfnrarh 663 30 % % NN cord-345222-otfnrarh 663 31 of of IN cord-345222-otfnrarh 663 32 infected infected JJ cord-345222-otfnrarh 663 33 individuals individual NNS cord-345222-otfnrarh 663 34 will will MD cord-345222-otfnrarh 663 35 develop develop VB cord-345222-otfnrarh 663 36 HUS HUS NNP cord-345222-otfnrarh 663 37 following follow VBG cord-345222-otfnrarh 663 38 STEC STEC NNP cord-345222-otfnrarh 663 39 infection infection NN cord-345222-otfnrarh 663 40 with with IN cord-345222-otfnrarh 663 41 E. E. NNP cord-345222-otfnrarh 663 42 coli coli NNS cord-345222-otfnrarh 663 43 O157 O157 NNP cord-345222-otfnrarh 663 44 : : : cord-345222-otfnrarh 663 45 H7 H7 NNP cord-345222-otfnrarh 663 46 the the DT cord-345222-otfnrarh 663 47 most most RBS cord-345222-otfnrarh 663 48 commonly commonly RB cord-345222-otfnrarh 663 49 involved involve VBN cord-345222-otfnrarh 663 50 serotype serotype NN cord-345222-otfnrarh 663 51 , , , cord-345222-otfnrarh 663 52 antibiotics antibiotic NNS cord-345222-otfnrarh 663 53 should should MD cord-345222-otfnrarh 663 54 be be VB cord-345222-otfnrarh 663 55 prescribed prescribe VBN cord-345222-otfnrarh 663 56 according accord VBG cord-345222-otfnrarh 663 57 to to IN cord-345222-otfnrarh 663 58 more more JJR cord-345222-otfnrarh 663 59 recent recent JJ cord-345222-otfnrarh 663 60 guidelines guideline NNS cord-345222-otfnrarh 663 61 . . . cord-345222-otfnrarh 664 1 Moreover moreover RB cord-345222-otfnrarh 664 2 , , , cord-345222-otfnrarh 664 3 a a DT cord-345222-otfnrarh 664 4 major major JJ cord-345222-otfnrarh 664 5 concern concern NN cord-345222-otfnrarh 664 6 is be VBZ cord-345222-otfnrarh 664 7 the the DT cord-345222-otfnrarh 664 8 emergence emergence NN cord-345222-otfnrarh 664 9 of of IN cord-345222-otfnrarh 664 10 antibacterialresistant antibacterialresistant JJ cord-345222-otfnrarh 664 11 strains strain NNS cord-345222-otfnrarh 664 12 due due IN cord-345222-otfnrarh 664 13 to to IN cord-345222-otfnrarh 664 14 the the DT cord-345222-otfnrarh 664 15 widespread widespread JJ cord-345222-otfnrarh 664 16 use use NN cord-345222-otfnrarh 664 17 of of IN cord-345222-otfnrarh 664 18 antibacterial antibacterial JJ cord-345222-otfnrarh 664 19 agents agent NNS cord-345222-otfnrarh 664 20 : : : cord-345222-otfnrarh 664 21 a a DT cord-345222-otfnrarh 664 22 continuous continuous JJ cord-345222-otfnrarh 664 23 monitoring monitoring NN cord-345222-otfnrarh 664 24 of of IN cord-345222-otfnrarh 664 25 antibiotic antibiotic JJ cord-345222-otfnrarh 664 26 resistance resistance NN cord-345222-otfnrarh 664 27 in in IN cord-345222-otfnrarh 664 28 diarrhea diarrhea NN cord-345222-otfnrarh 664 29 - - HYPH cord-345222-otfnrarh 664 30 related relate VBN cord-345222-otfnrarh 664 31 bacterial bacterial JJ cord-345222-otfnrarh 664 32 pathogens pathogen NNS cord-345222-otfnrarh 664 33 is be VBZ cord-345222-otfnrarh 664 34 recommended recommend VBN cord-345222-otfnrarh 664 35 . . . cord-345222-otfnrarh 665 1 The the DT cord-345222-otfnrarh 665 2 benefits benefit NNS cord-345222-otfnrarh 665 3 and and CC cord-345222-otfnrarh 665 4 risks risk NNS cord-345222-otfnrarh 665 5 of of IN cord-345222-otfnrarh 665 6 adverse adverse JJ cord-345222-otfnrarh 665 7 drug drug NN cord-345222-otfnrarh 665 8 reactions reaction NNS cord-345222-otfnrarh 665 9 should should MD cord-345222-otfnrarh 665 10 be be VB cord-345222-otfnrarh 665 11 weighed weigh VBN cord-345222-otfnrarh 665 12 before before IN cord-345222-otfnrarh 665 13 prescribing prescribe VBG cord-345222-otfnrarh 665 14 any any DT cord-345222-otfnrarh 665 15 kind kind NN cord-345222-otfnrarh 665 16 of of IN cord-345222-otfnrarh 665 17 drug drug NN cord-345222-otfnrarh 665 18 . . . cord-345222-otfnrarh 666 1 The the DT cord-345222-otfnrarh 666 2 authors author NNS cord-345222-otfnrarh 666 3 report report VBP cord-345222-otfnrarh 666 4 no no DT cord-345222-otfnrarh 666 5 conflicts conflict NNS cord-345222-otfnrarh 666 6 of of IN cord-345222-otfnrarh 666 7 interest interest NN cord-345222-otfnrarh 666 8 in in IN cord-345222-otfnrarh 666 9 this this DT cord-345222-otfnrarh 666 10 work work NN cord-345222-otfnrarh 666 11 . . . cord-345222-otfnrarh 667 1 Review Review NNP cord-345222-otfnrarh 667 2 article article NN cord-345222-otfnrarh 667 3 : : : cord-345222-otfnrarh 667 4 the the DT cord-345222-otfnrarh 667 5 management management NN cord-345222-otfnrarh 667 6 of of IN cord-345222-otfnrarh 667 7 acute acute JJ cord-345222-otfnrarh 667 8 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 667 9 in in IN cord-345222-otfnrarh 667 10 children child NNS cord-345222-otfnrarh 668 1 The the DT cord-345222-otfnrarh 668 2 management management NN cord-345222-otfnrarh 668 3 of of IN cord-345222-otfnrarh 668 4 acute acute JJ cord-345222-otfnrarh 668 5 diarrhea diarrhea NN cord-345222-otfnrarh 668 6 in in IN cord-345222-otfnrarh 668 7 children child NNS cord-345222-otfnrarh 668 8 in in IN cord-345222-otfnrarh 668 9 developed developed JJ cord-345222-otfnrarh 668 10 and and CC cord-345222-otfnrarh 668 11 developing develop VBG cord-345222-otfnrarh 668 12 areas area NNS cord-345222-otfnrarh 668 13 : : : cord-345222-otfnrarh 668 14 from from IN cord-345222-otfnrarh 668 15 evidence evidence NN cord-345222-otfnrarh 668 16 base base NN cord-345222-otfnrarh 668 17 to to IN cord-345222-otfnrarh 668 18 clinical clinical JJ cord-345222-otfnrarh 668 19 practice practice NN cord-345222-otfnrarh 668 20 National National NNP cord-345222-otfnrarh 668 21 Collaborating Collaborating NNP cord-345222-otfnrarh 668 22 Centre Centre NNP cord-345222-otfnrarh 668 23 for for IN cord-345222-otfnrarh 668 24 Women Women NNPS cord-345222-otfnrarh 668 25 's 's POS cord-345222-otfnrarh 668 26 and and CC cord-345222-otfnrarh 668 27 Children Children NNP cord-345222-otfnrarh 668 28 's 's POS cord-345222-otfnrarh 668 29 Health Health NNP cord-345222-otfnrarh 668 30 . . . cord-345222-otfnrarh 669 1 Diarrhea diarrhea NN cord-345222-otfnrarh 669 2 and and CC cord-345222-otfnrarh 669 3 Vomiting vomiting NN cord-345222-otfnrarh 669 4 Caused cause VBN cord-345222-otfnrarh 669 5 by by IN cord-345222-otfnrarh 669 6 Gastroenteritis gastroenteritis NN cord-345222-otfnrarh 669 7 : : : cord-345222-otfnrarh 669 8 Diagnosis Diagnosis NNP cord-345222-otfnrarh 669 9 , , , cord-345222-otfnrarh 669 10 Assessment Assessment NNP cord-345222-otfnrarh 669 11 and and CC cord-345222-otfnrarh 669 12 Management Management NNP cord-345222-otfnrarh 669 13 in in IN cord-345222-otfnrarh 670 1 Children child NNS cord-345222-otfnrarh 670 2 Younger young JJR cord-345222-otfnrarh 671 1 Than than IN cord-345222-otfnrarh 671 2 5 5 CD cord-345222-otfnrarh 671 3 Years year NNS cord-345222-otfnrarh 672 1 Acute acute JJ cord-345222-otfnrarh 672 2 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 672 3 : : : cord-345222-otfnrarh 672 4 from from IN cord-345222-otfnrarh 672 5 guidelines guideline NNS cord-345222-otfnrarh 672 6 to to IN cord-345222-otfnrarh 672 7 real real JJ cord-345222-otfnrarh 672 8 life life NN cord-345222-otfnrarh 672 9 European European NNP cord-345222-otfnrarh 672 10 Society Society NNP cord-345222-otfnrarh 672 11 for for IN cord-345222-otfnrarh 672 12 Paediatric Paediatric NNP cord-345222-otfnrarh 672 13 Gastroenterology Gastroenterology NNP cord-345222-otfnrarh 672 14 , , , cord-345222-otfnrarh 672 15 Hepatology Hepatology NNP cord-345222-otfnrarh 672 16 , , , cord-345222-otfnrarh 672 17 and and CC cord-345222-otfnrarh 672 18 Nutrition Nutrition NNP cord-345222-otfnrarh 672 19 / / SYM cord-345222-otfnrarh 672 20 European European NNP cord-345222-otfnrarh 672 21 Society Society NNP cord-345222-otfnrarh 672 22 for for IN cord-345222-otfnrarh 672 23 Paediatric Paediatric NNP cord-345222-otfnrarh 672 24 Infectious Infectious NNP cord-345222-otfnrarh 672 25 Diseases Diseases NNPS cord-345222-otfnrarh 672 26 evidence evidence NN cord-345222-otfnrarh 672 27 - - HYPH cord-345222-otfnrarh 672 28 based base VBN cord-345222-otfnrarh 672 29 guidelines guideline NNS cord-345222-otfnrarh 672 30 for for IN cord-345222-otfnrarh 672 31 the the DT cord-345222-otfnrarh 672 32 management management NN cord-345222-otfnrarh 672 33 of of IN cord-345222-otfnrarh 672 34 acute acute JJ cord-345222-otfnrarh 672 35 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 672 36 in in IN cord-345222-otfnrarh 672 37 children child NNS cord-345222-otfnrarh 672 38 in in IN cord-345222-otfnrarh 672 39 Europe Europe NNP cord-345222-otfnrarh 672 40 Hospital Hospital NNP cord-345222-otfnrarh 672 41 - - HYPH cord-345222-otfnrarh 672 42 based base VBN cord-345222-otfnrarh 672 43 surveillance surveillance NN cord-345222-otfnrarh 672 44 to to TO cord-345222-otfnrarh 672 45 estimate estimate VB cord-345222-otfnrarh 672 46 the the DT cord-345222-otfnrarh 672 47 burden burden NN cord-345222-otfnrarh 672 48 of of IN cord-345222-otfnrarh 672 49 rotavirus rotavirus JJ cord-345222-otfnrarh 672 50 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 672 51 among among IN cord-345222-otfnrarh 672 52 European european JJ cord-345222-otfnrarh 672 53 children child NNS cord-345222-otfnrarh 672 54 younger young JJR cord-345222-otfnrarh 672 55 than than IN cord-345222-otfnrarh 672 56 5 5 CD cord-345222-otfnrarh 672 57 years year NNS cord-345222-otfnrarh 672 58 of of IN cord-345222-otfnrarh 672 59 age age NN cord-345222-otfnrarh 672 60 Rotavirus rotavirus NN cord-345222-otfnrarh 672 61 and and CC cord-345222-otfnrarh 672 62 not not RB cord-345222-otfnrarh 672 63 age age NN cord-345222-otfnrarh 672 64 determines determine VBZ cord-345222-otfnrarh 672 65 gastroenteritis gastroenteritis JJ cord-345222-otfnrarh 672 66 severity severity NN cord-345222-otfnrarh 672 67 in in IN cord-345222-otfnrarh 672 68 children child NNS cord-345222-otfnrarh 672 69 : : : cord-345222-otfnrarh 672 70 a a DT cord-345222-otfnrarh 672 71 hospital hospital NN cord-345222-otfnrarh 672 72 - - HYPH cord-345222-otfnrarh 672 73 based base VBN cord-345222-otfnrarh 672 74 study study NN cord-345222-otfnrarh 672 75 Rotavirus rotavirus NN cord-345222-otfnrarh 672 76 and and CC cord-345222-otfnrarh 672 77 severe severe JJ cord-345222-otfnrarh 672 78 childhood childhood NN cord-345222-otfnrarh 672 79 diarrhea diarrhea NN cord-345222-otfnrarh 672 80 Molecular molecular JJ cord-345222-otfnrarh 672 81 and and CC cord-345222-otfnrarh 672 82 clinical clinical JJ cord-345222-otfnrarh 672 83 characterization characterization NN cord-345222-otfnrarh 672 84 of of IN cord-345222-otfnrarh 672 85 rotavirus rotavirus NN cord-345222-otfnrarh 672 86 from from IN cord-345222-otfnrarh 672 87 diarrheal diarrheal JJ cord-345222-otfnrarh 672 88 infants infant NNS cord-345222-otfnrarh 672 89 admitted admit VBN cord-345222-otfnrarh 672 90 to to IN cord-345222-otfnrarh 672 91 pediatric pediatric JJ cord-345222-otfnrarh 672 92 emergency emergency NN cord-345222-otfnrarh 672 93 units unit NNS cord-345222-otfnrarh 672 94 in in IN cord-345222-otfnrarh 672 95 France France NNP cord-345222-otfnrarh 672 96 Diarrhea Diarrhea NNP cord-345222-otfnrarh 672 97 in in IN cord-345222-otfnrarh 672 98 children child NNS cord-345222-otfnrarh 672 99 : : : cord-345222-otfnrarh 672 100 etiology etiology NN cord-345222-otfnrarh 672 101 and and CC cord-345222-otfnrarh 672 102 clinical clinical JJ cord-345222-otfnrarh 672 103 aspects aspect NNS cord-345222-otfnrarh 672 104 Hospital hospital NN cord-345222-otfnrarh 672 105 - - HYPH cord-345222-otfnrarh 672 106 associated associate VBN cord-345222-otfnrarh 672 107 infections infection NNS cord-345222-otfnrarh 672 108 in in IN cord-345222-otfnrarh 672 109 children child NNS cord-345222-otfnrarh 672 110 : : : cord-345222-otfnrarh 672 111 a a DT cord-345222-otfnrarh 672 112 prospective prospective JJ cord-345222-otfnrarh 672 113 post post JJ cord-345222-otfnrarh 672 114 - - JJ cord-345222-otfnrarh 672 115 discharge discharge JJ cord-345222-otfnrarh 672 116 follow follow NN cord-345222-otfnrarh 672 117 - - HYPH cord-345222-otfnrarh 672 118 up up NN cord-345222-otfnrarh 672 119 survey survey NN cord-345222-otfnrarh 672 120 in in IN cord-345222-otfnrarh 672 121 three three CD cord-345222-otfnrarh 672 122 different different JJ cord-345222-otfnrarh 672 123 paediatric paediatric JJ cord-345222-otfnrarh 672 124 hospitals hospital NNS cord-345222-otfnrarh 672 125 Management Management NNP cord-345222-otfnrarh 672 126 guidelines guideline NNS cord-345222-otfnrarh 672 127 for for IN cord-345222-otfnrarh 672 128 acute acute JJ cord-345222-otfnrarh 672 129 infective infective JJ cord-345222-otfnrarh 672 130 diarrhoea/ diarrhoea/ CD cord-345222-otfnrarh 672 131 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 672 132 in in IN cord-345222-otfnrarh 672 133 infants infant NNS cord-345222-otfnrarh 672 134 Probiotics probiotic NNS cord-345222-otfnrarh 672 135 in in IN cord-345222-otfnrarh 672 136 the the DT cord-345222-otfnrarh 672 137 prevention prevention NN cord-345222-otfnrarh 672 138 of of IN cord-345222-otfnrarh 672 139 necrotizing necrotize VBG cord-345222-otfnrarh 672 140 enterocolitis enterocolitis NN cord-345222-otfnrarh 672 141 Probiotics probiotic NNS cord-345222-otfnrarh 672 142 and and CC cord-345222-otfnrarh 672 143 prebiotics prebiotic NNS cord-345222-otfnrarh 672 144 in in IN cord-345222-otfnrarh 672 145 prevention prevention NN cord-345222-otfnrarh 672 146 and and CC cord-345222-otfnrarh 672 147 treatment treatment NN cord-345222-otfnrarh 672 148 of of IN cord-345222-otfnrarh 672 149 diseases disease NNS cord-345222-otfnrarh 672 150 in in IN cord-345222-otfnrarh 672 151 infants infant NNS cord-345222-otfnrarh 672 152 and and CC cord-345222-otfnrarh 672 153 children child NNS cord-345222-otfnrarh 672 154 Probiotics probiotic NNS cord-345222-otfnrarh 672 155 in in IN cord-345222-otfnrarh 672 156 children child NNS cord-345222-otfnrarh 672 157 Breast breast NN cord-345222-otfnrarh 672 158 - - HYPH cord-345222-otfnrarh 672 159 feeding feeding NN cord-345222-otfnrarh 672 160 and and CC cord-345222-otfnrarh 672 161 hospitalization hospitalization NN cord-345222-otfnrarh 672 162 for for IN cord-345222-otfnrarh 672 163 diarrhoeal diarrhoeal NN cord-345222-otfnrarh 672 164 and and CC cord-345222-otfnrarh 672 165 respiratory respiratory JJ cord-345222-otfnrarh 672 166 infection infection NN cord-345222-otfnrarh 672 167 in in IN cord-345222-otfnrarh 672 168 the the DT cord-345222-otfnrarh 672 169 United United NNP cord-345222-otfnrarh 672 170 Kingdom Kingdom NNP cord-345222-otfnrarh 672 171 Millenium Millenium NNP cord-345222-otfnrarh 672 172 Cohort Cohort NNP cord-345222-otfnrarh 672 173 Study Study NNP cord-345222-otfnrarh 673 1 How how WRB cord-345222-otfnrarh 673 2 protective protective JJ cord-345222-otfnrarh 673 3 is be VBZ cord-345222-otfnrarh 673 4 breast breast NN cord-345222-otfnrarh 673 5 - - HYPH cord-345222-otfnrarh 673 6 feeding feed VBG cord-345222-otfnrarh 673 7 against against IN cord-345222-otfnrarh 673 8 diarrheal diarrheal JJ cord-345222-otfnrarh 673 9 disease disease NN cord-345222-otfnrarh 673 10 in in IN cord-345222-otfnrarh 673 11 infants infant NNS cord-345222-otfnrarh 673 12 in in IN cord-345222-otfnrarh 673 13 1990s 1990s CD cord-345222-otfnrarh 673 14 England England NNP cord-345222-otfnrarh 673 15 ? ? . cord-345222-otfnrarh 674 1 A a DT cord-345222-otfnrarh 674 2 case case NN cord-345222-otfnrarh 674 3 - - HYPH cord-345222-otfnrarh 674 4 control control NN cord-345222-otfnrarh 674 5 study study NN cord-345222-otfnrarh 674 6 Water Water NNP cord-345222-otfnrarh 674 7 supplementation supplementation NN cord-345222-otfnrarh 674 8 in in IN cord-345222-otfnrarh 674 9 exclusively exclusively RB cord-345222-otfnrarh 674 10 breastfed breastfed JJ cord-345222-otfnrarh 674 11 infants infant NNS cord-345222-otfnrarh 674 12 during during IN cord-345222-otfnrarh 674 13 summer summer NN cord-345222-otfnrarh 674 14 in in IN cord-345222-otfnrarh 674 15 the the DT cord-345222-otfnrarh 674 16 tropics tropic NNS cord-345222-otfnrarh 674 17 And and CC cord-345222-otfnrarh 674 18 not not RB cord-345222-otfnrarh 674 19 a a DT cord-345222-otfnrarh 674 20 drop drop NN cord-345222-otfnrarh 674 21 to to TO cord-345222-otfnrarh 674 22 drink drink VB cord-345222-otfnrarh 674 23 -why -why HYPH cord-345222-otfnrarh 674 24 water water NN cord-345222-otfnrarh 674 25 is be VBZ cord-345222-otfnrarh 674 26 harmful harmful JJ cord-345222-otfnrarh 674 27 for for IN cord-345222-otfnrarh 674 28 newborns newborn NNS cord-345222-otfnrarh 674 29 Burden Burden NNP cord-345222-otfnrarh 674 30 of of IN cord-345222-otfnrarh 674 31 Aeromonas Aeromonas NNP cord-345222-otfnrarh 674 32 hydrophilaassociated hydrophilaassociate VBD cord-345222-otfnrarh 674 33 diarrhea diarrhea NN cord-345222-otfnrarh 674 34 among among IN cord-345222-otfnrarh 674 35 children child NNS cord-345222-otfnrarh 674 36 younger young JJR cord-345222-otfnrarh 674 37 than than IN cord-345222-otfnrarh 674 38 2 2 CD cord-345222-otfnrarh 674 39 years year NNS cord-345222-otfnrarh 674 40 in in IN cord-345222-otfnrarh 674 41 rural rural JJ cord-345222-otfnrarh 674 42 Egyptian egyptian JJ cord-345222-otfnrarh 674 43 community community NN cord-345222-otfnrarh 674 44 Acute acute JJ cord-345222-otfnrarh 674 45 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 674 46 in in IN cord-345222-otfnrarh 674 47 children child NNS cord-345222-otfnrarh 675 1 The the DT cord-345222-otfnrarh 675 2 role role NN cord-345222-otfnrarh 675 3 of of IN cord-345222-otfnrarh 675 4 Campylobacter Campylobacter NNP cord-345222-otfnrarh 675 5 jejuni jejuni NNP cord-345222-otfnrarh 675 6 cytolethal cytolethal NNP cord-345222-otfnrarh 675 7 distending distend VBG cord-345222-otfnrarh 675 8 toxin toxin NN cord-345222-otfnrarh 675 9 in in IN cord-345222-otfnrarh 675 10 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 675 11 : : : cord-345222-otfnrarh 675 12 toxin toxin NN cord-345222-otfnrarh 675 13 detection detection NN cord-345222-otfnrarh 675 14 , , , cord-345222-otfnrarh 675 15 antibody antibody NN cord-345222-otfnrarh 675 16 production production NN cord-345222-otfnrarh 675 17 , , , cord-345222-otfnrarh 675 18 and and CC cord-345222-otfnrarh 675 19 clinical clinical JJ cord-345222-otfnrarh 675 20 outcome outcome NN cord-345222-otfnrarh 676 1 The the DT cord-345222-otfnrarh 676 2 epidemiology epidemiology NN cord-345222-otfnrarh 676 3 of of IN cord-345222-otfnrarh 676 4 Guillain Guillain NNP cord-345222-otfnrarh 676 5 - - HYPH cord-345222-otfnrarh 676 6 Barré Barré NNP cord-345222-otfnrarh 676 7 syndrome syndrome NN cord-345222-otfnrarh 676 8 worldwide worldwide RB cord-345222-otfnrarh 676 9 . . . cord-345222-otfnrarh 677 1 A a DT cord-345222-otfnrarh 677 2 systematic systematic JJ cord-345222-otfnrarh 677 3 literature literature NN cord-345222-otfnrarh 677 4 review review NN cord-345222-otfnrarh 677 5 Guillain Guillain NNP cord-345222-otfnrarh 677 6 - - HYPH cord-345222-otfnrarh 677 7 Barré Barré NNP cord-345222-otfnrarh 677 8 syndrome syndrome NN cord-345222-otfnrarh 677 9 and and CC cord-345222-otfnrarh 677 10 Campylobacter Campylobacter NNP cord-345222-otfnrarh 677 11 infection infection NN cord-345222-otfnrarh 677 12 Quantifying quantify VBG cord-345222-otfnrarh 677 13 the the DT cord-345222-otfnrarh 677 14 association association NN cord-345222-otfnrarh 677 15 between between IN cord-345222-otfnrarh 677 16 Campylobacter Campylobacter NNP cord-345222-otfnrarh 677 17 infection infection NN cord-345222-otfnrarh 677 18 and and CC cord-345222-otfnrarh 677 19 Guillain Guillain NNP cord-345222-otfnrarh 677 20 - - HYPH cord-345222-otfnrarh 677 21 Barré Barré NNP cord-345222-otfnrarh 677 22 syndrome syndrome NN cord-345222-otfnrarh 677 23 : : : cord-345222-otfnrarh 677 24 a a DT cord-345222-otfnrarh 677 25 systematic systematic JJ cord-345222-otfnrarh 677 26 review review NN cord-345222-otfnrarh 677 27 Antibiotic antibiotic NN cord-345222-otfnrarh 677 28 associated associate VBD cord-345222-otfnrarh 677 29 diarrhea diarrhea NN cord-345222-otfnrarh 677 30 in in IN cord-345222-otfnrarh 677 31 children child NNS cord-345222-otfnrarh 677 32 Increase increase VB cord-345222-otfnrarh 677 33 in in IN cord-345222-otfnrarh 677 34 Clostridium clostridium NN cord-345222-otfnrarh 677 35 difficilerelated difficilerelate VBD cord-345222-otfnrarh 677 36 hospitalizations hospitalization NNS cord-345222-otfnrarh 677 37 among among IN cord-345222-otfnrarh 677 38 infants infant NNS cord-345222-otfnrarh 677 39 in in IN cord-345222-otfnrarh 677 40 the the DT cord-345222-otfnrarh 677 41 United United NNP cord-345222-otfnrarh 677 42 States States NNP cord-345222-otfnrarh 677 43 Epidemiological Epidemiological NNP cord-345222-otfnrarh 677 44 features feature NNS cord-345222-otfnrarh 677 45 of of IN cord-345222-otfnrarh 677 46 Clostridium clostridium NN cord-345222-otfnrarh 677 47 difficile difficile NN cord-345222-otfnrarh 677 48 - - HYPH cord-345222-otfnrarh 677 49 associated associate VBN cord-345222-otfnrarh 677 50 disease disease NN cord-345222-otfnrarh 677 51 among among IN cord-345222-otfnrarh 677 52 inpatients inpatient NNS cord-345222-otfnrarh 677 53 at at IN cord-345222-otfnrarh 677 54 children child NNS cord-345222-otfnrarh 677 55 's 's POS cord-345222-otfnrarh 677 56 hospitals hospital NNS cord-345222-otfnrarh 677 57 in in IN cord-345222-otfnrarh 677 58 the the DT cord-345222-otfnrarh 677 59 United United NNP cord-345222-otfnrarh 677 60 States States NNP cord-345222-otfnrarh 677 61 Rapid Rapid NNP cord-345222-otfnrarh 677 62 stool stool NN cord-345222-otfnrarh 677 63 - - HYPH cord-345222-otfnrarh 677 64 based base VBN cord-345222-otfnrarh 677 65 diagnosis diagnosis NN cord-345222-otfnrarh 677 66 of of IN cord-345222-otfnrarh 677 67 Clostridium clostridium NN cord-345222-otfnrarh 677 68 difficile difficile NN cord-345222-otfnrarh 677 69 infection infection NN cord-345222-otfnrarh 677 70 by by IN cord-345222-otfnrarh 677 71 real real JJ cord-345222-otfnrarh 677 72 - - HYPH cord-345222-otfnrarh 677 73 time time NN cord-345222-otfnrarh 677 74 PCR PCR NNP cord-345222-otfnrarh 677 75 in in IN cord-345222-otfnrarh 677 76 a a DT cord-345222-otfnrarh 677 77 children child NNS cord-345222-otfnrarh 677 78 's 's POS cord-345222-otfnrarh 677 79 hospital hospital NN cord-345222-otfnrarh 677 80 Galveston Galveston NNP cord-345222-otfnrarh 677 81 ( ( -LRB- cord-345222-otfnrarh 677 82 TX TX NNP cord-345222-otfnrarh 677 83 ) ) -RRB- cord-345222-otfnrarh 677 84 : : : cord-345222-otfnrarh 677 85 University University NNP cord-345222-otfnrarh 677 86 of of IN cord-345222-otfnrarh 677 87 Texas Texas NNP cord-345222-otfnrarh 677 88 Medical Medical NNP cord-345222-otfnrarh 677 89 Branch Branch NNP cord-345222-otfnrarh 677 90 at at IN cord-345222-otfnrarh 677 91 Galveston Galveston NNP cord-345222-otfnrarh 677 92 Pyrosequencing Pyrosequencing NNP cord-345222-otfnrarh 677 93 - - HYPH cord-345222-otfnrarh 677 94 based base VBN cord-345222-otfnrarh 677 95 molecular molecular JJ cord-345222-otfnrarh 677 96 monitoring monitoring NN cord-345222-otfnrarh 677 97 of of IN cord-345222-otfnrarh 677 98 the the DT cord-345222-otfnrarh 677 99 intestinal intestinal JJ cord-345222-otfnrarh 677 100 bacterial bacterial JJ cord-345222-otfnrarh 677 101 colonization colonization NN cord-345222-otfnrarh 677 102 in in IN cord-345222-otfnrarh 677 103 preterm preterm JJ cord-345222-otfnrarh 677 104 infants infant NNS cord-345222-otfnrarh 677 105 Human human JJ cord-345222-otfnrarh 677 106 infections infection NNS cord-345222-otfnrarh 677 107 with with IN cord-345222-otfnrarh 677 108 non non JJ cord-345222-otfnrarh 677 109 - - JJ cord-345222-otfnrarh 677 110 O157 o157 JJ cord-345222-otfnrarh 677 111 Shiga Shiga NNP cord-345222-otfnrarh 677 112 toxin toxin NN cord-345222-otfnrarh 677 113 - - HYPH cord-345222-otfnrarh 677 114 producing produce VBG cord-345222-otfnrarh 677 115 Escherichia Escherichia NNP cord-345222-otfnrarh 677 116 coli coli NNS cord-345222-otfnrarh 677 117 Sporadic sporadic JJ cord-345222-otfnrarh 677 118 cases case NNS cord-345222-otfnrarh 677 119 of of IN cord-345222-otfnrarh 677 120 haemolyticuraemic haemolyticuraemic NNP cord-345222-otfnrarh 677 121 syndrome syndrome NN cord-345222-otfnrarh 677 122 associated associate VBN cord-345222-otfnrarh 677 123 with with IN cord-345222-otfnrarh 677 124 faecal faecal JJ cord-345222-otfnrarh 677 125 cytotoxin cytotoxin NN cord-345222-otfnrarh 677 126 and and CC cord-345222-otfnrarh 677 127 cytotoxinproducing cytotoxinproduce VBG cord-345222-otfnrarh 677 128 Escherichia Escherichia NNP cord-345222-otfnrarh 677 129 coli coli NNS cord-345222-otfnrarh 677 130 in in IN cord-345222-otfnrarh 677 131 stools stool NNS cord-345222-otfnrarh 677 132 Hemorrhagic hemorrhagic JJ cord-345222-otfnrarh 677 133 colitis colitis NN cord-345222-otfnrarh 677 134 associated associate VBN cord-345222-otfnrarh 677 135 with with IN cord-345222-otfnrarh 677 136 a a DT cord-345222-otfnrarh 677 137 rare rare JJ cord-345222-otfnrarh 677 138 Escherichia Escherichia NNP cord-345222-otfnrarh 677 139 coli coli NNS cord-345222-otfnrarh 677 140 serotype serotype NN cord-345222-otfnrarh 677 141 Escherichia Escherichia NNP cord-345222-otfnrarh 677 142 coli coli NNS cord-345222-otfnrarh 677 143 O157 O157 NNP cord-345222-otfnrarh 677 144 : : : cord-345222-otfnrarh 677 145 H7 h7 NN cord-345222-otfnrarh 677 146 : : : cord-345222-otfnrarh 677 147 etiology etiology NN cord-345222-otfnrarh 677 148 , , , cord-345222-otfnrarh 677 149 clinical clinical JJ cord-345222-otfnrarh 677 150 features feature NNS cord-345222-otfnrarh 677 151 , , , cord-345222-otfnrarh 677 152 complications complication NNS cord-345222-otfnrarh 677 153 , , , cord-345222-otfnrarh 677 154 and and CC cord-345222-otfnrarh 677 155 treatment treatment NN cord-345222-otfnrarh 677 156 Diarrhoeagenic Diarrhoeagenic NNP cord-345222-otfnrarh 677 157 Escherichia Escherichia NNP cord-345222-otfnrarh 677 158 coli coli NNS cord-345222-otfnrarh 677 159 -an -an NNS cord-345222-otfnrarh 677 160 emerging emerge VBG cord-345222-otfnrarh 677 161 problem problem NN cord-345222-otfnrarh 677 162 ? ? . cord-345222-otfnrarh 678 1 Epidemiology epidemiology NN cord-345222-otfnrarh 678 2 of of IN cord-345222-otfnrarh 678 3 Shiga Shiga NNP cord-345222-otfnrarh 678 4 toxin toxin NN cord-345222-otfnrarh 678 5 producing produce VBG cord-345222-otfnrarh 678 6 Escherichia Escherichia NNP cord-345222-otfnrarh 678 7 coli coli NNS cord-345222-otfnrarh 678 8 in in IN cord-345222-otfnrarh 678 9 Australia Australia NNP cord-345222-otfnrarh 679 1 The the DT cord-345222-otfnrarh 679 2 non non JJ cord-345222-otfnrarh 679 3 - - JJ cord-345222-otfnrarh 679 4 O157 o157 JJ cord-345222-otfnrarh 679 5 Shiga Shiga NNP cord-345222-otfnrarh 679 6 toxigenic toxigenic NN cord-345222-otfnrarh 679 7 ( ( -LRB- cord-345222-otfnrarh 679 8 verotocytotoxigenic verotocytotoxigenic NNP cord-345222-otfnrarh 679 9 ) ) -RRB- cord-345222-otfnrarh 680 1 Escherichia escherichia NN cord-345222-otfnrarh 680 2 coli coli NNS cord-345222-otfnrarh 680 3 : : : cord-345222-otfnrarh 681 1 under under RB cord-345222-otfnrarh 681 2 - - HYPH cord-345222-otfnrarh 681 3 rated rate VBN cord-345222-otfnrarh 681 4 pathogens pathogen NNS cord-345222-otfnrarh 682 1 The the DT cord-345222-otfnrarh 682 2 epidemiology epidemiology NN cord-345222-otfnrarh 682 3 of of IN cord-345222-otfnrarh 682 4 infections infection NNS cord-345222-otfnrarh 682 5 caused cause VBN cord-345222-otfnrarh 682 6 by by IN cord-345222-otfnrarh 682 7 Escherichia Escherichia NNP cord-345222-otfnrarh 682 8 coli coli NNS cord-345222-otfnrarh 682 9 O157 O157 NNP cord-345222-otfnrarh 682 10 : : : cord-345222-otfnrarh 682 11 H7 H7 NNP cord-345222-otfnrarh 682 12 , , , cord-345222-otfnrarh 683 1 other other JJ cord-345222-otfnrarh 683 2 enterohemorrhagic enterohemorrhagic NNP cord-345222-otfnrarh 683 3 E. E. NNP cord-345222-otfnrarh 683 4 coli coli NNS cord-345222-otfnrarh 683 5 , , , cord-345222-otfnrarh 683 6 and and CC cord-345222-otfnrarh 683 7 the the DT cord-345222-otfnrarh 683 8 associated associated JJ cord-345222-otfnrarh 683 9 hemolytic hemolytic JJ cord-345222-otfnrarh 683 10 uremic uremic JJ cord-345222-otfnrarh 683 11 syndrome syndrome NN cord-345222-otfnrarh 684 1 The the DT cord-345222-otfnrarh 684 2 community community NN cord-345222-otfnrarh 684 3 summary summary NN cord-345222-otfnrarh 684 4 report report NN cord-345222-otfnrarh 684 5 on on IN cord-345222-otfnrarh 684 6 trends trend NNS cord-345222-otfnrarh 684 7 and and CC cord-345222-otfnrarh 684 8 sources source NNS cord-345222-otfnrarh 684 9 of of IN cord-345222-otfnrarh 684 10 zoonoses zoonosis NNS cord-345222-otfnrarh 684 11 and and CC cord-345222-otfnrarh 684 12 zoonotic zoonotic JJ cord-345222-otfnrarh 684 13 agents agent NNS cord-345222-otfnrarh 684 14 in in IN cord-345222-otfnrarh 684 15 the the DT cord-345222-otfnrarh 684 16 European European NNP cord-345222-otfnrarh 684 17 Union Union NNP cord-345222-otfnrarh 684 18 in in IN cord-345222-otfnrarh 684 19 2008 2008 CD cord-345222-otfnrarh 684 20 Recommendations Recommendations NNPS cord-345222-otfnrarh 684 21 for for IN cord-345222-otfnrarh 684 22 diagnosis diagnosis NN cord-345222-otfnrarh 684 23 of of IN cord-345222-otfnrarh 684 24 shiga shiga NNP cord-345222-otfnrarh 684 25 toxin toxin NN cord-345222-otfnrarh 684 26 - - HYPH cord-345222-otfnrarh 684 27 producing produce VBG cord-345222-otfnrarh 684 28 Escherichia Escherichia NNP cord-345222-otfnrarh 684 29 coli coli NNS cord-345222-otfnrarh 684 30 infections infection NNS cord-345222-otfnrarh 684 31 by by IN cord-345222-otfnrarh 684 32 clinical clinical JJ cord-345222-otfnrarh 684 33 laboratories laboratory NNS cord-345222-otfnrarh 685 1 Helicobacter helicobacter NN cord-345222-otfnrarh 685 2 pylori pylori NN cord-345222-otfnrarh 685 3 and and CC cord-345222-otfnrarh 685 4 risk risk NN cord-345222-otfnrarh 685 5 of of IN cord-345222-otfnrarh 685 6 gastroenteritis gastroenteritis JJ cord-345222-otfnrarh 685 7 Helicobacter Helicobacter NNP cord-345222-otfnrarh 685 8 pylori pylori NN cord-345222-otfnrarh 685 9 in in IN cord-345222-otfnrarh 685 10 Gambian gambian JJ cord-345222-otfnrarh 685 11 children child NNS cord-345222-otfnrarh 685 12 with with IN cord-345222-otfnrarh 685 13 chronic chronic JJ cord-345222-otfnrarh 685 14 diarrhoea diarrhoea NN cord-345222-otfnrarh 685 15 and and CC cord-345222-otfnrarh 685 16 malnutrition malnutrition NN cord-345222-otfnrarh 685 17 Impact impact NN cord-345222-otfnrarh 685 18 of of IN cord-345222-otfnrarh 685 19 infection infection NN cord-345222-otfnrarh 685 20 by by IN cord-345222-otfnrarh 685 21 Helicobacter Helicobacter NNP cord-345222-otfnrarh 685 22 pylori pylori NN cord-345222-otfnrarh 685 23 on on IN cord-345222-otfnrarh 685 24 the the DT cord-345222-otfnrarh 685 25 risk risk NN cord-345222-otfnrarh 685 26 and and CC cord-345222-otfnrarh 685 27 severity severity NN cord-345222-otfnrarh 685 28 of of IN cord-345222-otfnrarh 685 29 endemic endemic JJ cord-345222-otfnrarh 685 30 cholera cholera NN cord-345222-otfnrarh 685 31 Association Association NNP cord-345222-otfnrarh 685 32 between between IN cord-345222-otfnrarh 685 33 Helicobacter Helicobacter NNP cord-345222-otfnrarh 685 34 pylori pylori NN cord-345222-otfnrarh 685 35 infection infection NN cord-345222-otfnrarh 685 36 and and CC cord-345222-otfnrarh 685 37 increased increase VBN cord-345222-otfnrarh 685 38 risk risk NN cord-345222-otfnrarh 685 39 of of IN cord-345222-otfnrarh 685 40 typhoid typhoid NN cord-345222-otfnrarh 685 41 fever fever NN cord-345222-otfnrarh 686 1 Acute acute JJ cord-345222-otfnrarh 686 2 Helicobacter Helicobacter NNP cord-345222-otfnrarh 686 3 pylori pylori NN cord-345222-otfnrarh 686 4 infection infection NN cord-345222-otfnrarh 686 5 is be VBZ cord-345222-otfnrarh 686 6 followed follow VBN cord-345222-otfnrarh 686 7 by by IN cord-345222-otfnrarh 686 8 an an DT cord-345222-otfnrarh 686 9 increase increase NN cord-345222-otfnrarh 686 10 in in IN cord-345222-otfnrarh 686 11 diarrheal diarrheal JJ cord-345222-otfnrarh 686 12 disease disease NN cord-345222-otfnrarh 686 13 among among IN cord-345222-otfnrarh 686 14 Peruvian peruvian JJ cord-345222-otfnrarh 686 15 children child NNS cord-345222-otfnrarh 686 16 Prospective prospective JJ cord-345222-otfnrarh 686 17 study study NN cord-345222-otfnrarh 686 18 of of IN cord-345222-otfnrarh 686 19 the the DT cord-345222-otfnrarh 686 20 incidence incidence NN cord-345222-otfnrarh 686 21 of of IN cord-345222-otfnrarh 686 22 diarrheal diarrheal JJ cord-345222-otfnrarh 686 23 disease disease NN cord-345222-otfnrarh 686 24 and and CC cord-345222-otfnrarh 686 25 Helicobacter Helicobacter NNP cord-345222-otfnrarh 686 26 pylori pylori NN cord-345222-otfnrarh 686 27 infection infection NN cord-345222-otfnrarh 686 28 among among IN cord-345222-otfnrarh 686 29 children child NNS cord-345222-otfnrarh 686 30 in in IN cord-345222-otfnrarh 686 31 an an DT cord-345222-otfnrarh 686 32 orphanage orphanage NN cord-345222-otfnrarh 686 33 in in IN cord-345222-otfnrarh 686 34 Thailand Thailand NNP cord-345222-otfnrarh 686 35 Antibacterial Antibacterial NNP cord-345222-otfnrarh 686 36 peptide peptide NN cord-345222-otfnrarh 686 37 from from IN cord-345222-otfnrarh 686 38 H. H. NNP cord-345222-otfnrarh 686 39 pylori pylori NN cord-345222-otfnrarh 686 40 Inverse inverse NN cord-345222-otfnrarh 686 41 relationship relationship NN cord-345222-otfnrarh 686 42 between between IN cord-345222-otfnrarh 686 43 gastric gastric JJ cord-345222-otfnrarh 686 44 colonization colonization NN cord-345222-otfnrarh 686 45 of of IN cord-345222-otfnrarh 686 46 Helicobacter Helicobacter NNP cord-345222-otfnrarh 686 47 pylori pylori NN cord-345222-otfnrarh 686 48 and and CC cord-345222-otfnrarh 686 49 diarrheal diarrheal JJ cord-345222-otfnrarh 686 50 illnesses illness NNS cord-345222-otfnrarh 686 51 in in IN cord-345222-otfnrarh 686 52 children child NNS cord-345222-otfnrarh 686 53 : : : cord-345222-otfnrarh 686 54 results result NNS cord-345222-otfnrarh 686 55 of of IN cord-345222-otfnrarh 686 56 a a DT cord-345222-otfnrarh 686 57 population population NN cord-345222-otfnrarh 686 58 - - HYPH cord-345222-otfnrarh 686 59 based base VBN cord-345222-otfnrarh 686 60 cross cross JJ cord-345222-otfnrarh 686 61 - - JJ cord-345222-otfnrarh 686 62 sectional sectional JJ cord-345222-otfnrarh 686 63 study study NN cord-345222-otfnrarh 687 1 The the DT cord-345222-otfnrarh 687 2 gastric gastric JJ cord-345222-otfnrarh 687 3 biology biology NN cord-345222-otfnrarh 687 4 of of IN cord-345222-otfnrarh 687 5 Helicobacter helicobacter NN cord-345222-otfnrarh 687 6 pylori pylori NN cord-345222-otfnrarh 687 7 Gastrointestinal gastrointestinal JJ cord-345222-otfnrarh 687 8 symptoms symptom NNS cord-345222-otfnrarh 687 9 and and CC cord-345222-otfnrarh 687 10 Helicobacter Helicobacter NNP cord-345222-otfnrarh 687 11 pylori pylori NN cord-345222-otfnrarh 687 12 infection infection NN cord-345222-otfnrarh 687 13 in in IN cord-345222-otfnrarh 687 14 school school NN cord-345222-otfnrarh 687 15 - - HYPH cord-345222-otfnrarh 687 16 age age NN cord-345222-otfnrarh 687 17 children child NNS cord-345222-otfnrarh 687 18 residing reside VBG cord-345222-otfnrarh 687 19 in in IN cord-345222-otfnrarh 687 20 Porto Porto NNP cord-345222-otfnrarh 687 21 Torres Torres NNP cord-345222-otfnrarh 687 22 Epidemiological Epidemiological NNP cord-345222-otfnrarh 687 23 studies study NNS cord-345222-otfnrarh 687 24 on on IN cord-345222-otfnrarh 687 25 proteeae proteeae NNP cord-345222-otfnrarh 687 26 isolates isolate NNS cord-345222-otfnrarh 687 27 from from IN cord-345222-otfnrarh 687 28 clinical clinical JJ cord-345222-otfnrarh 687 29 specimens specimen NNS cord-345222-otfnrarh 687 30 in in IN cord-345222-otfnrarh 687 31 the the DT cord-345222-otfnrarh 687 32 Laquintinie Laquintinie NNP cord-345222-otfnrarh 687 33 Hospital Hospital NNP cord-345222-otfnrarh 687 34 in in IN cord-345222-otfnrarh 687 35 Douala Douala NNP cord-345222-otfnrarh 687 36 , , , cord-345222-otfnrarh 687 37 Cameroon Cameroon NNP cord-345222-otfnrarh 687 38 Pseudomonas Pseudomonas NNP cord-345222-otfnrarh 687 39 aeruginosa aeruginosa VBZ cord-345222-otfnrarh 687 40 in in IN cord-345222-otfnrarh 687 41 a a DT cord-345222-otfnrarh 687 42 neonatal neonatal JJ cord-345222-otfnrarh 687 43 intensive intensive JJ cord-345222-otfnrarh 687 44 care care NN cord-345222-otfnrarh 687 45 unit unit NN cord-345222-otfnrarh 687 46 : : : cord-345222-otfnrarh 687 47 molecular molecular JJ cord-345222-otfnrarh 687 48 epidemiology epidemiology NN cord-345222-otfnrarh 687 49 and and CC cord-345222-otfnrarh 687 50 infection infection NN cord-345222-otfnrarh 687 51 control control NN cord-345222-otfnrarh 687 52 measures measure VBZ cord-345222-otfnrarh 687 53 Infectious infectious JJ cord-345222-otfnrarh 687 54 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 687 55 . . . cord-345222-otfnrarh 688 1 From from IN cord-345222-otfnrarh 688 2 : : : cord-345222-otfnrarh 688 3 Neonatal neonatal JJ cord-345222-otfnrarh 688 4 Infectious Infectious NNP cord-345222-otfnrarh 688 5 Diseases Diseases NNPS cord-345222-otfnrarh 688 6 Study Study NNP cord-345222-otfnrarh 688 7 Group Group NNP cord-345222-otfnrarh 688 8 of of IN cord-345222-otfnrarh 688 9 the the DT cord-345222-otfnrarh 688 10 Italian Italian NNP cord-345222-otfnrarh 688 11 Society Society NNP cord-345222-otfnrarh 688 12 of of IN cord-345222-otfnrarh 688 13 Neonatology Neonatology NNP cord-345222-otfnrarh 688 14 . . . cord-345222-otfnrarh 689 1 Manual Manual NNP cord-345222-otfnrarh 689 2 of of IN cord-345222-otfnrarh 689 3 Neonatal Neonatal NNP cord-345222-otfnrarh 689 4 Infectious Infectious NNP cord-345222-otfnrarh 689 5 Diseases Diseases NNPS cord-345222-otfnrarh 689 6 Live live VBP cord-345222-otfnrarh 689 7 attenuated attenuated JJ cord-345222-otfnrarh 689 8 Shigella Shigella NNP cord-345222-otfnrarh 689 9 dysenteriae dysenteriae NN cord-345222-otfnrarh 689 10 type type NN cord-345222-otfnrarh 689 11 1 1 CD cord-345222-otfnrarh 689 12 vaccine vaccine NN cord-345222-otfnrarh 689 13 strains strain NNS cord-345222-otfnrarh 689 14 overexpressing overexpresse VBG cord-345222-otfnrarh 689 15 shiga shiga NNP cord-345222-otfnrarh 689 16 toxin toxin NN cord-345222-otfnrarh 689 17 B B NNP cord-345222-otfnrarh 689 18 subunit subunit NN cord-345222-otfnrarh 689 19 Yersinia Yersinia NNP cord-345222-otfnrarh 689 20 enterocolitica enterocolitica NNP cord-345222-otfnrarh 689 21 infection infection NN cord-345222-otfnrarh 689 22 among among IN cord-345222-otfnrarh 689 23 children child NNS cord-345222-otfnrarh 689 24 aged age VBN cord-345222-otfnrarh 689 25 less less JJR cord-345222-otfnrarh 689 26 than than IN cord-345222-otfnrarh 689 27 12 12 CD cord-345222-otfnrarh 689 28 years year NNS cord-345222-otfnrarh 689 29 : : : cord-345222-otfnrarh 689 30 a a DT cord-345222-otfnrarh 689 31 case case NN cord-345222-otfnrarh 689 32 - - HYPH cord-345222-otfnrarh 689 33 control control NN cord-345222-otfnrarh 689 34 study study NN cord-345222-otfnrarh 690 1 The the DT cord-345222-otfnrarh 690 2 pathogenic pathogenic JJ cord-345222-otfnrarh 690 3 potential potential NN cord-345222-otfnrarh 690 4 of of IN cord-345222-otfnrarh 690 5 Yersinia Yersinia NNP cord-345222-otfnrarh 690 6 enterocolitica enterocolitica NNP cord-345222-otfnrarh 690 7 1A 1a NN cord-345222-otfnrarh 690 8 Viral viral JJ cord-345222-otfnrarh 690 9 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 690 10 in in IN cord-345222-otfnrarh 690 11 children child NNS cord-345222-otfnrarh 690 12 Diagnosis diagnosis NN cord-345222-otfnrarh 690 13 and and CC cord-345222-otfnrarh 690 14 treatment treatment NN cord-345222-otfnrarh 690 15 of of IN cord-345222-otfnrarh 690 16 acute acute JJ cord-345222-otfnrarh 690 17 or or CC cord-345222-otfnrarh 690 18 persistent persistent JJ cord-345222-otfnrarh 690 19 diarrhea diarrhea NN cord-345222-otfnrarh 690 20 Infections Infections NNPS cord-345222-otfnrarh 690 21 and and CC cord-345222-otfnrarh 690 22 Pediatric Pediatric NNP cord-345222-otfnrarh 690 23 Pharmacotheray Pharmacotheray NNP cord-345222-otfnrarh 690 24 Viral viral JJ cord-345222-otfnrarh 690 25 infections infection NNS cord-345222-otfnrarh 690 26 of of IN cord-345222-otfnrarh 690 27 the the DT cord-345222-otfnrarh 690 28 gastrointestinal gastrointestinal JJ cord-345222-otfnrarh 690 29 tract tract NN cord-345222-otfnrarh 690 30 Epidemiological epidemiological JJ cord-345222-otfnrarh 690 31 and and CC cord-345222-otfnrarh 690 32 clinical clinical JJ cord-345222-otfnrarh 690 33 characteristics characteristic NNS cord-345222-otfnrarh 690 34 of of IN cord-345222-otfnrarh 690 35 pediatric pediatric JJ cord-345222-otfnrarh 690 36 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 690 37 associated associate VBN cord-345222-otfnrarh 690 38 with with IN cord-345222-otfnrarh 690 39 new new JJ cord-345222-otfnrarh 690 40 viral viral JJ cord-345222-otfnrarh 690 41 agents agent NNS cord-345222-otfnrarh 690 42 Worldwide worldwide IN cord-345222-otfnrarh 690 43 emergence emergence NN cord-345222-otfnrarh 690 44 of of IN cord-345222-otfnrarh 690 45 multiple multiple JJ cord-345222-otfnrarh 690 46 clades clade NNS cord-345222-otfnrarh 690 47 of of IN cord-345222-otfnrarh 690 48 enterovirus enterovirus NN cord-345222-otfnrarh 690 49 68 68 CD cord-345222-otfnrarh 690 50 Diversity diversity NN cord-345222-otfnrarh 690 51 in in IN cord-345222-otfnrarh 690 52 the the DT cord-345222-otfnrarh 690 53 enteric enteric JJ cord-345222-otfnrarh 690 54 viruses virus NNS cord-345222-otfnrarh 690 55 detected detect VBN cord-345222-otfnrarh 690 56 in in IN cord-345222-otfnrarh 690 57 outbreaks outbreak NNS cord-345222-otfnrarh 690 58 of of IN cord-345222-otfnrarh 690 59 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 690 60 from from IN cord-345222-otfnrarh 690 61 Mumbai Mumbai NNP cord-345222-otfnrarh 690 62 , , , cord-345222-otfnrarh 690 63 Western Western NNP cord-345222-otfnrarh 690 64 India India NNP cord-345222-otfnrarh 690 65 Excretion Excretion NNP cord-345222-otfnrarh 690 66 of of IN cord-345222-otfnrarh 690 67 enterovirus enterovirus NN cord-345222-otfnrarh 690 68 71 71 CD cord-345222-otfnrarh 690 69 in in IN cord-345222-otfnrarh 690 70 persons person NNS cord-345222-otfnrarh 690 71 infected infect VBN cord-345222-otfnrarh 690 72 with with IN cord-345222-otfnrarh 690 73 hand hand NN cord-345222-otfnrarh 690 74 , , , cord-345222-otfnrarh 690 75 foot foot NN cord-345222-otfnrarh 690 76 and and CC cord-345222-otfnrarh 690 77 mouth mouth NN cord-345222-otfnrarh 690 78 disease disease NN cord-345222-otfnrarh 690 79 Pleconaril Pleconaril NNP cord-345222-otfnrarh 690 80 revisited revisit VBD cord-345222-otfnrarh 690 81 : : : cord-345222-otfnrarh 691 1 clinical clinical JJ cord-345222-otfnrarh 691 2 course course NN cord-345222-otfnrarh 691 3 of of IN cord-345222-otfnrarh 691 4 chronic chronic JJ cord-345222-otfnrarh 691 5 enteroviral enteroviral JJ cord-345222-otfnrarh 691 6 meningoencephalitis meningoencephalitis NN cord-345222-otfnrarh 691 7 after after IN cord-345222-otfnrarh 691 8 treatment treatment NN cord-345222-otfnrarh 691 9 correlates correlate VBZ cord-345222-otfnrarh 691 10 with with IN cord-345222-otfnrarh 691 11 in in IN cord-345222-otfnrarh 691 12 vitro vitro FW cord-345222-otfnrarh 691 13 susceptibility susceptibility NN cord-345222-otfnrarh 691 14 Immunogenicity immunogenicity NN cord-345222-otfnrarh 691 15 and and CC cord-345222-otfnrarh 691 16 safety safety NN cord-345222-otfnrarh 691 17 of of IN cord-345222-otfnrarh 691 18 an an DT cord-345222-otfnrarh 691 19 enterovirus enterovirus NN cord-345222-otfnrarh 691 20 71 71 CD cord-345222-otfnrarh 691 21 vaccine vaccine NN cord-345222-otfnrarh 691 22 in in IN cord-345222-otfnrarh 691 23 healthy healthy JJ cord-345222-otfnrarh 691 24 Chinese chinese JJ cord-345222-otfnrarh 691 25 children child NNS cord-345222-otfnrarh 691 26 and and CC cord-345222-otfnrarh 691 27 infants infant NNS cord-345222-otfnrarh 691 28 : : : cord-345222-otfnrarh 691 29 a a DT cord-345222-otfnrarh 691 30 randomised randomised JJ cord-345222-otfnrarh 691 31 , , , cord-345222-otfnrarh 691 32 double double JJ cord-345222-otfnrarh 691 33 - - HYPH cord-345222-otfnrarh 691 34 blind blind JJ cord-345222-otfnrarh 691 35 , , , cord-345222-otfnrarh 691 36 placebo placebo NN cord-345222-otfnrarh 691 37 - - HYPH cord-345222-otfnrarh 691 38 controlled control VBN cord-345222-otfnrarh 691 39 phase phase NN cord-345222-otfnrarh 691 40 2 2 CD cord-345222-otfnrarh 691 41 clinical clinical JJ cord-345222-otfnrarh 691 42 trial trial NN cord-345222-otfnrarh 691 43 Viral viral JJ cord-345222-otfnrarh 691 44 load load NN cord-345222-otfnrarh 691 45 of of IN cord-345222-otfnrarh 691 46 human human JJ cord-345222-otfnrarh 691 47 bocavirus-1 bocavirus-1 NN cord-345222-otfnrarh 691 48 in in IN cord-345222-otfnrarh 691 49 stools stool NNS cord-345222-otfnrarh 691 50 from from IN cord-345222-otfnrarh 691 51 children child NNS cord-345222-otfnrarh 691 52 with with IN cord-345222-otfnrarh 691 53 viral viral JJ cord-345222-otfnrarh 691 54 diarrhoea diarrhoea NN cord-345222-otfnrarh 691 55 in in IN cord-345222-otfnrarh 691 56 Paraguay Paraguay NNP cord-345222-otfnrarh 691 57 Detection Detection NNP cord-345222-otfnrarh 691 58 of of IN cord-345222-otfnrarh 691 59 human human JJ cord-345222-otfnrarh 691 60 coronaviruses coronaviruse NNS cord-345222-otfnrarh 691 61 in in IN cord-345222-otfnrarh 691 62 children child NNS cord-345222-otfnrarh 691 63 with with IN cord-345222-otfnrarh 691 64 acute acute JJ cord-345222-otfnrarh 691 65 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 691 66 Prevalence prevalence NN cord-345222-otfnrarh 691 67 of of IN cord-345222-otfnrarh 691 68 Norwalk Norwalk NNP cord-345222-otfnrarh 691 69 - - HYPH cord-345222-otfnrarh 691 70 like like JJ cord-345222-otfnrarh 691 71 virus virus NN cord-345222-otfnrarh 691 72 infections infection NNS cord-345222-otfnrarh 691 73 in in IN cord-345222-otfnrarh 691 74 cases case NNS cord-345222-otfnrarh 691 75 of of IN cord-345222-otfnrarh 691 76 viral viral JJ cord-345222-otfnrarh 691 77 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 691 78 among among IN cord-345222-otfnrarh 691 79 children child NNS cord-345222-otfnrarh 691 80 in in IN cord-345222-otfnrarh 691 81 Osaka Osaka NNP cord-345222-otfnrarh 691 82 City City NNP cord-345222-otfnrarh 691 83 Epidemiological epidemiological JJ cord-345222-otfnrarh 691 84 aspects aspect NNS cord-345222-otfnrarh 691 85 of of IN cord-345222-otfnrarh 691 86 human human JJ cord-345222-otfnrarh 691 87 rotavirus rotavirus JJ cord-345222-otfnrarh 691 88 infection infection NN cord-345222-otfnrarh 691 89 in in IN cord-345222-otfnrarh 691 90 children child NNS cord-345222-otfnrarh 691 91 hospitalized hospitalize VBN cord-345222-otfnrarh 691 92 with with IN cord-345222-otfnrarh 691 93 acute acute JJ cord-345222-otfnrarh 691 94 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 691 95 in in IN cord-345222-otfnrarh 691 96 an an DT cord-345222-otfnrarh 691 97 area area NN cord-345222-otfnrarh 691 98 of of IN cord-345222-otfnrarh 691 99 northern northern JJ cord-345222-otfnrarh 691 100 Italy Italy NNP cord-345222-otfnrarh 691 101 Human Human NNP cord-345222-otfnrarh 691 102 caliciviruses caliciviruse NNS cord-345222-otfnrarh 691 103 and and CC cord-345222-otfnrarh 691 104 pediatric pediatric JJ cord-345222-otfnrarh 691 105 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 691 106 Outbreak outbreak NN cord-345222-otfnrarh 691 107 of of IN cord-345222-otfnrarh 691 108 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 691 109 due due JJ cord-345222-otfnrarh 691 110 to to IN cord-345222-otfnrarh 691 111 sapovirus sapovirus NNP cord-345222-otfnrarh 691 112 Human Human NNP cord-345222-otfnrarh 691 113 sapovirus sapovirus NNP cord-345222-otfnrarh 691 114 classification classification NN cord-345222-otfnrarh 691 115 based base VBN cord-345222-otfnrarh 691 116 on on IN cord-345222-otfnrarh 691 117 complete complete JJ cord-345222-otfnrarh 691 118 capsid capsid NN cord-345222-otfnrarh 691 119 nucleotide nucleotide JJ cord-345222-otfnrarh 691 120 sequences sequence NNS cord-345222-otfnrarh 691 121 Detection detection NN cord-345222-otfnrarh 691 122 and and CC cord-345222-otfnrarh 691 123 follow follow NN cord-345222-otfnrarh 691 124 - - HYPH cord-345222-otfnrarh 691 125 up up NN cord-345222-otfnrarh 691 126 of of IN cord-345222-otfnrarh 691 127 torque torque NN cord-345222-otfnrarh 691 128 teno teno NNP cord-345222-otfnrarh 691 129 midi midi NNP cord-345222-otfnrarh 691 130 virus virus NNP cord-345222-otfnrarh 691 131 ( ( -LRB- cord-345222-otfnrarh 691 132 " " `` cord-345222-otfnrarh 691 133 small small JJ cord-345222-otfnrarh 691 134 anelloviruses anelloviruse NNS cord-345222-otfnrarh 691 135 " " '' cord-345222-otfnrarh 691 136 ) ) -RRB- cord-345222-otfnrarh 691 137 in in IN cord-345222-otfnrarh 691 138 nasopharyngeal nasopharyngeal JJ cord-345222-otfnrarh 691 139 aspirates aspirate NNS cord-345222-otfnrarh 691 140 and and CC cord-345222-otfnrarh 691 141 three three CD cord-345222-otfnrarh 691 142 other other JJ cord-345222-otfnrarh 691 143 human human JJ cord-345222-otfnrarh 691 144 body body NN cord-345222-otfnrarh 691 145 fluids fluid NNS cord-345222-otfnrarh 691 146 in in IN cord-345222-otfnrarh 691 147 children child NNS cord-345222-otfnrarh 691 148 Isolation isolation NN cord-345222-otfnrarh 691 149 of of IN cord-345222-otfnrarh 691 150 multiple multiple JJ cord-345222-otfnrarh 691 151 TT TT NNP cord-345222-otfnrarh 691 152 virus virus NN cord-345222-otfnrarh 691 153 genotypes genotype NNS cord-345222-otfnrarh 691 154 from from IN cord-345222-otfnrarh 691 155 spleen spleen NN cord-345222-otfnrarh 691 156 biopsy biopsy NN cord-345222-otfnrarh 691 157 tissue tissue NN cord-345222-otfnrarh 691 158 from from IN cord-345222-otfnrarh 691 159 a a DT cord-345222-otfnrarh 691 160 Hodgkin Hodgkin NNP cord-345222-otfnrarh 691 161 's 's POS cord-345222-otfnrarh 691 162 disease disease NN cord-345222-otfnrarh 691 163 patient patient NN cord-345222-otfnrarh 691 164 : : : cord-345222-otfnrarh 691 165 genome genome NN cord-345222-otfnrarh 691 166 reorganization reorganization NN cord-345222-otfnrarh 691 167 and and CC cord-345222-otfnrarh 691 168 diversity diversity NN cord-345222-otfnrarh 691 169 in in IN cord-345222-otfnrarh 691 170 the the DT cord-345222-otfnrarh 691 171 hypervariable hypervariable JJ cord-345222-otfnrarh 691 172 region region NN cord-345222-otfnrarh 691 173 Analysis Analysis NNP cord-345222-otfnrarh 691 174 of of IN cord-345222-otfnrarh 691 175 the the DT cord-345222-otfnrarh 691 176 entire entire JJ cord-345222-otfnrarh 691 177 genomes genome NNS cord-345222-otfnrarh 691 178 of of IN cord-345222-otfnrarh 691 179 thirteen thirteen CD cord-345222-otfnrarh 691 180 TT TT NNP cord-345222-otfnrarh 691 181 virus virus NN cord-345222-otfnrarh 691 182 variants variant NNS cord-345222-otfnrarh 691 183 classifiable classifiable JJ cord-345222-otfnrarh 691 184 into into IN cord-345222-otfnrarh 691 185 the the DT cord-345222-otfnrarh 691 186 fourth fourth JJ cord-345222-otfnrarh 691 187 and and CC cord-345222-otfnrarh 691 188 fifth fifth JJ cord-345222-otfnrarh 691 189 genetic genetic JJ cord-345222-otfnrarh 691 190 groups group NNS cord-345222-otfnrarh 691 191 , , , cord-345222-otfnrarh 691 192 isolated isolate VBN cord-345222-otfnrarh 691 193 from from IN cord-345222-otfnrarh 691 194 viremic viremic JJ cord-345222-otfnrarh 691 195 infants infant NNS cord-345222-otfnrarh 691 196 Torque Torque NNP cord-345222-otfnrarh 691 197 teno teno NNP cord-345222-otfnrarh 691 198 virus virus NN cord-345222-otfnrarh 691 199 infection infection NN cord-345222-otfnrarh 691 200 in in IN cord-345222-otfnrarh 691 201 the the DT cord-345222-otfnrarh 691 202 pig pig NN cord-345222-otfnrarh 691 203 and and CC cord-345222-otfnrarh 691 204 its -PRON- PRP$ cord-345222-otfnrarh 691 205 potential potential JJ cord-345222-otfnrarh 691 206 role role NN cord-345222-otfnrarh 691 207 as as IN cord-345222-otfnrarh 691 208 a a DT cord-345222-otfnrarh 691 209 model model NN cord-345222-otfnrarh 691 210 of of IN cord-345222-otfnrarh 691 211 human human JJ cord-345222-otfnrarh 691 212 infection infection NN cord-345222-otfnrarh 692 1 An an DT cord-345222-otfnrarh 692 2 unusual unusual JJ cord-345222-otfnrarh 692 3 case case NN cord-345222-otfnrarh 692 4 report report NN cord-345222-otfnrarh 692 5 of of IN cord-345222-otfnrarh 692 6 small small JJ cord-345222-otfnrarh 692 7 bowel bowel NN cord-345222-otfnrarh 692 8 Candida Candida NNP cord-345222-otfnrarh 692 9 overgrowth overgrowth NN cord-345222-otfnrarh 692 10 as as IN cord-345222-otfnrarh 692 11 a a DT cord-345222-otfnrarh 692 12 cause cause NN cord-345222-otfnrarh 692 13 of of IN cord-345222-otfnrarh 692 14 diarrhea diarrhea NN cord-345222-otfnrarh 692 15 and and CC cord-345222-otfnrarh 692 16 review review NN cord-345222-otfnrarh 692 17 of of IN cord-345222-otfnrarh 692 18 the the DT cord-345222-otfnrarh 692 19 literature literature NN cord-345222-otfnrarh 692 20 Invasive invasive JJ cord-345222-otfnrarh 692 21 Candida Candida NNP cord-345222-otfnrarh 692 22 enteritis enteritis NN cord-345222-otfnrarh 692 23 of of IN cord-345222-otfnrarh 692 24 the the DT cord-345222-otfnrarh 692 25 newborn newborn JJ cord-345222-otfnrarh 692 26 Prevalence prevalence NN cord-345222-otfnrarh 692 27 of of IN cord-345222-otfnrarh 692 28 Candida Candida NNP cord-345222-otfnrarh 692 29 colonization colonization NN cord-345222-otfnrarh 692 30 in in IN cord-345222-otfnrarh 692 31 preterm preterm JJ cord-345222-otfnrarh 692 32 newborns newborn NNS cord-345222-otfnrarh 692 33 and and CC cord-345222-otfnrarh 692 34 VLBW VLBW NNP cord-345222-otfnrarh 692 35 in in IN cord-345222-otfnrarh 692 36 neonatal neonatal JJ cord-345222-otfnrarh 692 37 intensive intensive JJ cord-345222-otfnrarh 692 38 care care NN cord-345222-otfnrarh 692 39 unit unit NN cord-345222-otfnrarh 692 40 : : : cord-345222-otfnrarh 692 41 role role NN cord-345222-otfnrarh 692 42 of of IN cord-345222-otfnrarh 692 43 maternal maternal JJ cord-345222-otfnrarh 692 44 colonization colonization NN cord-345222-otfnrarh 692 45 as as IN cord-345222-otfnrarh 692 46 a a DT cord-345222-otfnrarh 692 47 risk risk NN cord-345222-otfnrarh 692 48 factor factor NN cord-345222-otfnrarh 692 49 in in IN cord-345222-otfnrarh 692 50 transmission transmission NN cord-345222-otfnrarh 692 51 of of IN cord-345222-otfnrarh 692 52 disease disease NN cord-345222-otfnrarh 692 53 Candida Candida NNP cord-345222-otfnrarh 692 54 colonization colonization NN cord-345222-otfnrarh 692 55 in in IN cord-345222-otfnrarh 692 56 the the DT cord-345222-otfnrarh 692 57 nursery nursery NN cord-345222-otfnrarh 692 58 Antifungal antifungal JJ cord-345222-otfnrarh 692 59 therapy therapy NN cord-345222-otfnrarh 692 60 for for IN cord-345222-otfnrarh 692 61 neonatal neonatal JJ cord-345222-otfnrarh 692 62 candidiasis candidiasis NN cord-345222-otfnrarh 692 63 Safety Safety NNP cord-345222-otfnrarh 692 64 and and CC cord-345222-otfnrarh 692 65 pharmacokinetics pharmacokinetic NNS cord-345222-otfnrarh 692 66 of of IN cord-345222-otfnrarh 692 67 repeat repeat NN cord-345222-otfnrarh 692 68 - - HYPH cord-345222-otfnrarh 692 69 dose dose NN cord-345222-otfnrarh 692 70 micafungin micafungin NN cord-345222-otfnrarh 692 71 in in IN cord-345222-otfnrarh 692 72 young young JJ cord-345222-otfnrarh 692 73 infants infant NNS cord-345222-otfnrarh 692 74 Pediatric pediatric JJ cord-345222-otfnrarh 692 75 antifungal antifungal JJ cord-345222-otfnrarh 692 76 therapy therapy NN cord-345222-otfnrarh 692 77 . . . cord-345222-otfnrarh 693 1 Part part NN cord-345222-otfnrarh 693 2 II II NNP cord-345222-otfnrarh 693 3 : : : cord-345222-otfnrarh 693 4 neonatal neonatal JJ cord-345222-otfnrarh 693 5 infections infection NNS cord-345222-otfnrarh 694 1 Neonatal neonatal JJ cord-345222-otfnrarh 694 2 fungal fungal JJ cord-345222-otfnrarh 694 3 infections infection NNS cord-345222-otfnrarh 694 4 : : : cord-345222-otfnrarh 694 5 when when WRB cord-345222-otfnrarh 694 6 to to TO cord-345222-otfnrarh 694 7 treat treat VB cord-345222-otfnrarh 694 8 ? ? . cord-345222-otfnrarh 695 1 Getting get VBG cord-345222-otfnrarh 695 2 to to IN cord-345222-otfnrarh 695 3 zero zero CD cord-345222-otfnrarh 695 4 " " '' cord-345222-otfnrarh 695 5 : : : cord-345222-otfnrarh 695 6 preventing prevent VBG cord-345222-otfnrarh 695 7 invasive invasive JJ cord-345222-otfnrarh 695 8 Candida Candida NNP cord-345222-otfnrarh 695 9 infections infection NNS cord-345222-otfnrarh 695 10 and and CC cord-345222-otfnrarh 695 11 eliminating eliminate VBG cord-345222-otfnrarh 695 12 infection infection NN cord-345222-otfnrarh 695 13 - - HYPH cord-345222-otfnrarh 695 14 related relate VBN cord-345222-otfnrarh 695 15 mortality mortality NN cord-345222-otfnrarh 695 16 and and CC cord-345222-otfnrarh 695 17 morbidity morbidity NN cord-345222-otfnrarh 695 18 in in IN cord-345222-otfnrarh 695 19 extremely extremely RB cord-345222-otfnrarh 695 20 preterm preterm JJ cord-345222-otfnrarh 695 21 infants infant NNS cord-345222-otfnrarh 695 22 Strategies strategy NNS cord-345222-otfnrarh 695 23 for for IN cord-345222-otfnrarh 695 24 the the DT cord-345222-otfnrarh 695 25 prevention prevention NN cord-345222-otfnrarh 695 26 of of IN cord-345222-otfnrarh 695 27 neonatal neonatal JJ cord-345222-otfnrarh 695 28 candidiasis candidiasis NN cord-345222-otfnrarh 695 29 Dysfunctions dysfunction NNS cord-345222-otfnrarh 695 30 at at IN cord-345222-otfnrarh 695 31 human human JJ cord-345222-otfnrarh 695 32 intestinal intestinal JJ cord-345222-otfnrarh 695 33 barrier barrier NN cord-345222-otfnrarh 695 34 by by IN cord-345222-otfnrarh 695 35 water water NN cord-345222-otfnrarh 695 36 - - HYPH cord-345222-otfnrarh 695 37 borne bear VBN cord-345222-otfnrarh 695 38 protozoan protozoan NN cord-345222-otfnrarh 695 39 parasites parasite NNS cord-345222-otfnrarh 695 40 : : : cord-345222-otfnrarh 695 41 lessons lesson NNS cord-345222-otfnrarh 695 42 from from IN cord-345222-otfnrarh 695 43 cultured cultured JJ cord-345222-otfnrarh 695 44 human human JJ cord-345222-otfnrarh 695 45 fully fully RB cord-345222-otfnrarh 695 46 - - HYPH cord-345222-otfnrarh 695 47 differentiated differentiate VBN cord-345222-otfnrarh 695 48 colon colon NN cord-345222-otfnrarh 695 49 cancer cancer NN cord-345222-otfnrarh 695 50 cell cell NN cord-345222-otfnrarh 695 51 lines line NNS cord-345222-otfnrarh 695 52 Investigation Investigation NNP cord-345222-otfnrarh 695 53 of of IN cord-345222-otfnrarh 695 54 Cryptosporidium Cryptosporidium NNP cord-345222-otfnrarh 695 55 spp spp NNS cord-345222-otfnrarh 695 56 . . . cord-345222-otfnrarh 696 1 antigen antigen NNP cord-345222-otfnrarh 696 2 by by IN cord-345222-otfnrarh 696 3 ELISA ELISA NNP cord-345222-otfnrarh 696 4 method method NN cord-345222-otfnrarh 696 5 in in IN cord-345222-otfnrarh 696 6 stool stool NN cord-345222-otfnrarh 696 7 specimens specimen NNS cord-345222-otfnrarh 696 8 obtained obtain VBN cord-345222-otfnrarh 696 9 from from IN cord-345222-otfnrarh 696 10 patients patient NNS cord-345222-otfnrarh 696 11 with with IN cord-345222-otfnrarh 696 12 diarrhea diarrhea NN cord-345222-otfnrarh 697 1 Giardia Giardia NNP cord-345222-otfnrarh 697 2 intestinalis intestinalis NNP cord-345222-otfnrarh 697 3 Giardia Giardia NNP cord-345222-otfnrarh 697 4 lamblia lamblia NNP cord-345222-otfnrarh 697 5 : : : cord-345222-otfnrarh 697 6 a a DT cord-345222-otfnrarh 697 7 major major JJ cord-345222-otfnrarh 697 8 parasitic parasitic JJ cord-345222-otfnrarh 697 9 cause cause NN cord-345222-otfnrarh 697 10 of of IN cord-345222-otfnrarh 697 11 childhood childhood NN cord-345222-otfnrarh 697 12 diarrhoea diarrhoea NN cord-345222-otfnrarh 697 13 in in IN cord-345222-otfnrarh 697 14 patients patient NNS cord-345222-otfnrarh 697 15 attending attend VBG cord-345222-otfnrarh 697 16 a a DT cord-345222-otfnrarh 697 17 district district NN cord-345222-otfnrarh 697 18 hospital hospital NN cord-345222-otfnrarh 697 19 in in IN cord-345222-otfnrarh 697 20 Ghana Ghana NNP cord-345222-otfnrarh 697 21 Prevalence Prevalence NNP cord-345222-otfnrarh 697 22 and and CC cord-345222-otfnrarh 697 23 species species NN cord-345222-otfnrarh 697 24 distribution distribution NN cord-345222-otfnrarh 697 25 of of IN cord-345222-otfnrarh 697 26 E. E. NNP cord-345222-otfnrarh 697 27 histolytica histolytica NNP cord-345222-otfnrarh 697 28 and and CC cord-345222-otfnrarh 697 29 E. E. NNP cord-345222-otfnrarh 697 30 dispar dispar NNP cord-345222-otfnrarh 697 31 in in IN cord-345222-otfnrarh 697 32 the the DT cord-345222-otfnrarh 697 33 Venda Venda NNP cord-345222-otfnrarh 697 34 region region NN cord-345222-otfnrarh 697 35 Prospective prospective JJ cord-345222-otfnrarh 697 36 case case NN cord-345222-otfnrarh 697 37 - - HYPH cord-345222-otfnrarh 697 38 control control NN cord-345222-otfnrarh 697 39 study study NN cord-345222-otfnrarh 697 40 of of IN cord-345222-otfnrarh 697 41 the the DT cord-345222-otfnrarh 697 42 association association NN cord-345222-otfnrarh 697 43 between between IN cord-345222-otfnrarh 697 44 common common JJ cord-345222-otfnrarh 697 45 enteric enteric JJ cord-345222-otfnrarh 697 46 protozoal protozoal NN cord-345222-otfnrarh 697 47 parasites parasite NNS cord-345222-otfnrarh 697 48 and and CC cord-345222-otfnrarh 697 49 diarrhea diarrhea NN cord-345222-otfnrarh 697 50 in in IN cord-345222-otfnrarh 697 51 Bangladesh Bangladesh NNP cord-345222-otfnrarh 697 52 Symptomatic symptomatic JJ cord-345222-otfnrarh 697 53 chronic chronic JJ cord-345222-otfnrarh 697 54 strongyloidiasis strongyloidiasis NN cord-345222-otfnrarh 697 55 in in IN cord-345222-otfnrarh 697 56 children child NNS cord-345222-otfnrarh 697 57 following follow VBG cord-345222-otfnrarh 697 58 treatment treatment NN cord-345222-otfnrarh 697 59 for for IN cord-345222-otfnrarh 697 60 solid solid JJ cord-345222-otfnrarh 697 61 organ organ NN cord-345222-otfnrarh 697 62 malignancies malignancy NNS cord-345222-otfnrarh 697 63 : : : cord-345222-otfnrarh 697 64 case case NN cord-345222-otfnrarh 697 65 reports report NNS cord-345222-otfnrarh 697 66 and and CC cord-345222-otfnrarh 697 67 literature literature NN cord-345222-otfnrarh 697 68 review review NN cord-345222-otfnrarh 697 69 Clostridium clostridium NN cord-345222-otfnrarh 697 70 difficile difficile NN cord-345222-otfnrarh 697 71 infection infection NN cord-345222-otfnrarh 697 72 : : : cord-345222-otfnrarh 697 73 essential essential JJ cord-345222-otfnrarh 697 74 information information NN cord-345222-otfnrarh 697 75 for for IN cord-345222-otfnrarh 697 76 nurses nurse NNS cord-345222-otfnrarh 698 1 Rotavirus rotavirus NN cord-345222-otfnrarh 698 2 infection infection NN cord-345222-otfnrarh 698 3 in in IN cord-345222-otfnrarh 698 4 a a DT cord-345222-otfnrarh 698 5 tertiary tertiary JJ cord-345222-otfnrarh 698 6 hospital hospital NN cord-345222-otfnrarh 698 7 : : : cord-345222-otfnrarh 698 8 laboratory laboratory NN cord-345222-otfnrarh 698 9 diagnosis diagnosis NN cord-345222-otfnrarh 698 10 and and CC cord-345222-otfnrarh 698 11 impact impact NN cord-345222-otfnrarh 698 12 of of IN cord-345222-otfnrarh 698 13 immunization immunization NN cord-345222-otfnrarh 698 14 on on IN cord-345222-otfnrarh 698 15 pediatric pediatric JJ cord-345222-otfnrarh 698 16 hospitalization hospitalization NN cord-345222-otfnrarh 698 17 Prevalence prevalence NN cord-345222-otfnrarh 698 18 of of IN cord-345222-otfnrarh 698 19 Providencia Providencia NNP cord-345222-otfnrarh 698 20 strains strain NNS cord-345222-otfnrarh 698 21 among among IN cord-345222-otfnrarh 698 22 children child NNS cord-345222-otfnrarh 698 23 with with IN cord-345222-otfnrarh 698 24 diarrhea diarrhea NN cord-345222-otfnrarh 698 25 in in IN cord-345222-otfnrarh 698 26 Japan Japan NNP cord-345222-otfnrarh 698 27 Prevalence Prevalence NNP cord-345222-otfnrarh 698 28 of of IN cord-345222-otfnrarh 698 29 diarrheagenic diarrheagenic JJ cord-345222-otfnrarh 698 30 Escherichia Escherichia NNP cord-345222-otfnrarh 698 31 coli coli VBZ cord-345222-otfnrarh 698 32 virulence virulence NN cord-345222-otfnrarh 698 33 genes gene NNS cord-345222-otfnrarh 698 34 in in IN cord-345222-otfnrarh 698 35 the the DT cord-345222-otfnrarh 698 36 feces fece NNS cord-345222-otfnrarh 698 37 of of IN cord-345222-otfnrarh 698 38 slaughtered slaughter VBN cord-345222-otfnrarh 698 39 cattle cattle NNS cord-345222-otfnrarh 698 40 , , , cord-345222-otfnrarh 698 41 chickens chicken NNS cord-345222-otfnrarh 698 42 , , , cord-345222-otfnrarh 698 43 and and CC cord-345222-otfnrarh 698 44 pigs pig NNS cord-345222-otfnrarh 698 45 in in IN cord-345222-otfnrarh 698 46 Burkina Burkina NNP cord-345222-otfnrarh 698 47 Faso Faso NNP cord-345222-otfnrarh 698 48 Molecular Molecular NNP cord-345222-otfnrarh 698 49 analysis analysis NN cord-345222-otfnrarh 698 50 of of IN cord-345222-otfnrarh 698 51 typical typical JJ cord-345222-otfnrarh 698 52 and and CC cord-345222-otfnrarh 698 53 atypical atypical JJ cord-345222-otfnrarh 698 54 enteropathogenic enteropathogenic JJ cord-345222-otfnrarh 698 55 Escherichia escherichia NN cord-345222-otfnrarh 698 56 coli coli NNS cord-345222-otfnrarh 698 57 ( ( -LRB- cord-345222-otfnrarh 698 58 EPEC EPEC NNP cord-345222-otfnrarh 698 59 ) ) -RRB- cord-345222-otfnrarh 698 60 isolated isolate VBN cord-345222-otfnrarh 698 61 from from IN cord-345222-otfnrarh 698 62 children child NNS cord-345222-otfnrarh 698 63 with with IN cord-345222-otfnrarh 698 64 diarrhoea diarrhoea NN cord-345222-otfnrarh 698 65 Guidance Guidance NNP cord-345222-otfnrarh 698 66 on on IN cord-345222-otfnrarh 698 67 infection infection NN cord-345222-otfnrarh 698 68 control control NN cord-345222-otfnrarh 698 69 in in IN cord-345222-otfnrarh 698 70 schools school NNS cord-345222-otfnrarh 698 71 and and CC cord-345222-otfnrarh 698 72 other other JJ cord-345222-otfnrarh 698 73 childcare childcare NN cord-345222-otfnrarh 698 74 settings setting NNS cord-345222-otfnrarh 699 1 Preventing prevent VBG cord-345222-otfnrarh 699 2 person person NN cord-345222-otfnrarh 699 3 - - HYPH cord-345222-otfnrarh 699 4 to to IN cord-345222-otfnrarh 699 5 - - HYPH cord-345222-otfnrarh 699 6 person person NN cord-345222-otfnrarh 699 7 spread spread VB cord-345222-otfnrarh 699 8 following follow VBG cord-345222-otfnrarh 699 9 gastrointestinal gastrointestinal JJ cord-345222-otfnrarh 699 10 infections infection NNS cord-345222-otfnrarh 699 11 : : : cord-345222-otfnrarh 699 12 guidelines guideline NNS cord-345222-otfnrarh 699 13 for for IN cord-345222-otfnrarh 699 14 public public JJ cord-345222-otfnrarh 699 15 health health NN cord-345222-otfnrarh 699 16 physicians physician NNS cord-345222-otfnrarh 699 17 and and CC cord-345222-otfnrarh 699 18 environmental environmental JJ cord-345222-otfnrarh 699 19 health health NN cord-345222-otfnrarh 699 20 officers officer NNS cord-345222-otfnrarh 699 21 Association Association NNP cord-345222-otfnrarh 699 22 between between IN cord-345222-otfnrarh 699 23 pentavalent pentavalent NNP cord-345222-otfnrarh 699 24 rotavirus rotavirus JJ cord-345222-otfnrarh 699 25 vaccine vaccine NN cord-345222-otfnrarh 699 26 and and CC cord-345222-otfnrarh 699 27 severe severe JJ cord-345222-otfnrarh 699 28 rotavirus rotavirus JJ cord-345222-otfnrarh 699 29 diarrhoea diarrhoea NN cord-345222-otfnrarh 699 30 among among IN cord-345222-otfnrarh 699 31 children child NNS cord-345222-otfnrarh 699 32 in in IN cord-345222-otfnrarh 699 33 Nicaragua Nicaragua NNP cord-345222-otfnrarh 699 34 Uptake Uptake NNP cord-345222-otfnrarh 699 35 , , , cord-345222-otfnrarh 699 36 impact impact NN cord-345222-otfnrarh 699 37 , , , cord-345222-otfnrarh 699 38 and and CC cord-345222-otfnrarh 699 39 effectiveness effectiveness NN cord-345222-otfnrarh 699 40 of of IN cord-345222-otfnrarh 699 41 rotavirus rotavirus JJ cord-345222-otfnrarh 699 42 vaccination vaccination NN cord-345222-otfnrarh 699 43 in in IN cord-345222-otfnrarh 699 44 the the DT cord-345222-otfnrarh 699 45 United United NNP cord-345222-otfnrarh 699 46 States States NNP cord-345222-otfnrarh 699 47 : : : cord-345222-otfnrarh 699 48 review review NN cord-345222-otfnrarh 699 49 of of IN cord-345222-otfnrarh 699 50 the the DT cord-345222-otfnrarh 699 51 first first JJ cord-345222-otfnrarh 699 52 3 3 CD cord-345222-otfnrarh 699 53 years year NNS cord-345222-otfnrarh 699 54 of of IN cord-345222-otfnrarh 699 55 postlicensure postlicensure NNP cord-345222-otfnrarh 699 56 data datum NNS cord-345222-otfnrarh 700 1 The the DT cord-345222-otfnrarh 700 2 effect effect NN cord-345222-otfnrarh 700 3 of of IN cord-345222-otfnrarh 700 4 rotavirus rotavirus JJ cord-345222-otfnrarh 700 5 vaccine vaccine NN cord-345222-otfnrarh 700 6 on on IN cord-345222-otfnrarh 700 7 diarrhea diarrhea NN cord-345222-otfnrarh 700 8 mortality mortality NN cord-345222-otfnrarh 700 9 European European NNP cord-345222-otfnrarh 700 10 Society Society NNP cord-345222-otfnrarh 700 11 for for IN cord-345222-otfnrarh 700 12 Paediatric Paediatric NNP cord-345222-otfnrarh 700 13 Infectious Infectious NNP cord-345222-otfnrarh 700 14 Diseases Diseases NNPS cord-345222-otfnrarh 700 15 / / SYM cord-345222-otfnrarh 700 16 European European NNP cord-345222-otfnrarh 700 17 Society Society NNP cord-345222-otfnrarh 700 18 for for IN cord-345222-otfnrarh 700 19 Paediatric Paediatric NNP cord-345222-otfnrarh 700 20 Gastroenterology Gastroenterology NNP cord-345222-otfnrarh 700 21 , , , cord-345222-otfnrarh 700 22 Hepatology Hepatology NNP cord-345222-otfnrarh 700 23 , , , cord-345222-otfnrarh 700 24 and and CC cord-345222-otfnrarh 700 25 Nutrition Nutrition NNP cord-345222-otfnrarh 700 26 evidence evidence NN cord-345222-otfnrarh 700 27 - - HYPH cord-345222-otfnrarh 700 28 based base VBN cord-345222-otfnrarh 700 29 recommendations recommendation NNS cord-345222-otfnrarh 700 30 for for IN cord-345222-otfnrarh 700 31 rotavirus rotavirus JJ cord-345222-otfnrarh 700 32 vaccination vaccination NN cord-345222-otfnrarh 700 33 in in IN cord-345222-otfnrarh 700 34 Europe Europe NNP cord-345222-otfnrarh 700 35 Prevention Prevention NNP cord-345222-otfnrarh 700 36 of of IN cord-345222-otfnrarh 700 37 rotavirus rotavirus JJ cord-345222-otfnrarh 700 38 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 700 39 among among IN cord-345222-otfnrarh 700 40 infants infant NNS cord-345222-otfnrarh 700 41 and and CC cord-345222-otfnrarh 700 42 children child NNS cord-345222-otfnrarh 700 43 . . . cord-345222-otfnrarh 701 1 Recommendations recommendation NNS cord-345222-otfnrarh 701 2 of of IN cord-345222-otfnrarh 701 3 the the DT cord-345222-otfnrarh 701 4 Advisory Advisory NNP cord-345222-otfnrarh 701 5 Committee Committee NNP cord-345222-otfnrarh 701 6 on on IN cord-345222-otfnrarh 701 7 Immunization Immunization NNP cord-345222-otfnrarh 701 8 Practices Practices NNPS cord-345222-otfnrarh 701 9 ( ( -LRB- cord-345222-otfnrarh 701 10 ACIP ACIP NNP cord-345222-otfnrarh 701 11 ) ) -RRB- cord-345222-otfnrarh 701 12 Effect effect NN cord-345222-otfnrarh 701 13 on on IN cord-345222-otfnrarh 701 14 clinical clinical JJ cord-345222-otfnrarh 701 15 outcome outcome NN cord-345222-otfnrarh 701 16 of of IN cord-345222-otfnrarh 701 17 breast breast NN cord-345222-otfnrarh 701 18 feeding feeding NN cord-345222-otfnrarh 701 19 during during IN cord-345222-otfnrarh 701 20 acute acute JJ cord-345222-otfnrarh 701 21 diarrhoea diarrhoea NN cord-345222-otfnrarh 701 22 Management management NN cord-345222-otfnrarh 701 23 of of IN cord-345222-otfnrarh 701 24 infectious infectious JJ cord-345222-otfnrarh 701 25 diarrhoea diarrhoea NN cord-345222-otfnrarh 701 26 Breast Breast NNP cord-345222-otfnrarh 701 27 milk milk NN cord-345222-otfnrarh 701 28 as as IN cord-345222-otfnrarh 701 29 the the DT cord-345222-otfnrarh 701 30 gold gold NN cord-345222-otfnrarh 701 31 standard standard NN cord-345222-otfnrarh 701 32 for for IN cord-345222-otfnrarh 701 33 protective protective JJ cord-345222-otfnrarh 701 34 nutrients nutrient NNS cord-345222-otfnrarh 701 35 Breastfeeding breastfeed VBG cord-345222-otfnrarh 701 36 protects protect VBZ cord-345222-otfnrarh 701 37 against against IN cord-345222-otfnrarh 701 38 acute acute JJ cord-345222-otfnrarh 701 39 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 701 40 due due JJ cord-345222-otfnrarh 701 41 to to IN cord-345222-otfnrarh 701 42 rotavirus rotavirus NN cord-345222-otfnrarh 701 43 in in IN cord-345222-otfnrarh 701 44 infants infant NNS cord-345222-otfnrarh 701 45 Protective protective JJ cord-345222-otfnrarh 701 46 effect effect NN cord-345222-otfnrarh 701 47 of of IN cord-345222-otfnrarh 701 48 exclusive exclusive JJ cord-345222-otfnrarh 701 49 breastfeeding breastfeeding NN cord-345222-otfnrarh 701 50 against against IN cord-345222-otfnrarh 701 51 infections infection NNS cord-345222-otfnrarh 701 52 during during IN cord-345222-otfnrarh 701 53 infancy infancy NN cord-345222-otfnrarh 701 54 : : : cord-345222-otfnrarh 702 1 a a DT cord-345222-otfnrarh 702 2 prospective prospective JJ cord-345222-otfnrarh 702 3 study study NN cord-345222-otfnrarh 702 4 Gastroenteric Gastroenteric NNP cord-345222-otfnrarh 702 5 pathology pathology NN cord-345222-otfnrarh 702 6 and and CC cord-345222-otfnrarh 702 7 probiotics probiotic NNS cord-345222-otfnrarh 702 8 : : : cord-345222-otfnrarh 702 9 from from IN cord-345222-otfnrarh 702 10 myth myth NN cord-345222-otfnrarh 702 11 to to IN cord-345222-otfnrarh 702 12 scientific scientific JJ cord-345222-otfnrarh 702 13 evidence evidence NN cord-345222-otfnrarh 702 14 . . . cord-345222-otfnrarh 703 1 Current current JJ cord-345222-otfnrarh 703 2 aspects aspect NNS cord-345222-otfnrarh 703 3 Probiotics probiotic NNS cord-345222-otfnrarh 703 4 : : : cord-345222-otfnrarh 703 5 from from IN cord-345222-otfnrarh 703 6 the the DT cord-345222-otfnrarh 703 7 ancient ancient JJ cord-345222-otfnrarh 703 8 wisdom wisdom NN cord-345222-otfnrarh 703 9 to to IN cord-345222-otfnrarh 703 10 the the DT cord-345222-otfnrarh 703 11 actual actual JJ cord-345222-otfnrarh 703 12 therapeutical therapeutical JJ cord-345222-otfnrarh 703 13 and and CC cord-345222-otfnrarh 703 14 nutraceutical nutraceutical JJ cord-345222-otfnrarh 703 15 perspective perspective NN cord-345222-otfnrarh 703 16 Probiotics probiotic NNS cord-345222-otfnrarh 703 17 for for IN cord-345222-otfnrarh 703 18 treating treat VBG cord-345222-otfnrarh 703 19 acute acute JJ cord-345222-otfnrarh 703 20 infectious infectious JJ cord-345222-otfnrarh 703 21 diarrhoea diarrhoea NN cord-345222-otfnrarh 703 22 Prophylactic prophylactic JJ cord-345222-otfnrarh 703 23 probiotics probiotic NNS cord-345222-otfnrarh 703 24 to to TO cord-345222-otfnrarh 703 25 prevent prevent VB cord-345222-otfnrarh 703 26 death death NN cord-345222-otfnrarh 703 27 and and CC cord-345222-otfnrarh 703 28 nosocomial nosocomial JJ cord-345222-otfnrarh 703 29 infection infection NN cord-345222-otfnrarh 703 30 in in IN cord-345222-otfnrarh 703 31 preterm preterm JJ cord-345222-otfnrarh 703 32 infants infant NNS cord-345222-otfnrarh 703 33 World World NNP cord-345222-otfnrarh 703 34 Health Health NNP cord-345222-otfnrarh 703 35 Organization Organization NNP cord-345222-otfnrarh 703 36 . . . cord-345222-otfnrarh 704 1 First First NNP cord-345222-otfnrarh 704 2 Steps Steps NNPS cord-345222-otfnrarh 704 3 for for IN cord-345222-otfnrarh 704 4 Managing manage VBG cord-345222-otfnrarh 704 5 an an DT cord-345222-otfnrarh 704 6 Outbreak outbreak NN cord-345222-otfnrarh 704 7 of of IN cord-345222-otfnrarh 704 8 Acute acute JJ cord-345222-otfnrarh 704 9 Diarrhea diarrhea NN cord-345222-otfnrarh 704 10 . . . cord-345222-otfnrarh 705 1 Geneva Geneva NNP cord-345222-otfnrarh 705 2 : : : cord-345222-otfnrarh 705 3 WHO who WP cord-345222-otfnrarh 705 4 Protocolo Protocolo NNP cord-345222-otfnrarh 705 5 de de NNP cord-345222-otfnrarh 705 6 Vigilancia Vigilancia NNP cord-345222-otfnrarh 705 7 Epidemiológica Epidemiológica NNP cord-345222-otfnrarh 705 8 de de IN cord-345222-otfnrarh 705 9 Cólera Cólera NNP cord-345222-otfnrarh 705 10 . . . cord-345222-otfnrarh 706 1 Lima Lima NNP cord-345222-otfnrarh 706 2 : : : cord-345222-otfnrarh 707 1 Oficina Oficina NNP cord-345222-otfnrarh 707 2 General General NNP cord-345222-otfnrarh 707 3 de de IN cord-345222-otfnrarh 707 4 Epidemiologia Epidemiologia NNP cord-345222-otfnrarh 707 5 Reduced reduce VBD cord-345222-otfnrarh 707 6 osmolarity osmolarity NN cord-345222-otfnrarh 707 7 oral oral JJ cord-345222-otfnrarh 707 8 rehydration rehydration NN cord-345222-otfnrarh 707 9 solution solution NN cord-345222-otfnrarh 707 10 for for IN cord-345222-otfnrarh 707 11 treating treat VBG cord-345222-otfnrarh 707 12 cholera cholera NN cord-345222-otfnrarh 707 13 Decrease decrease VB cord-345222-otfnrarh 707 14 in in IN cord-345222-otfnrarh 707 15 net net JJ cord-345222-otfnrarh 707 16 stool stool NN cord-345222-otfnrarh 707 17 output output NN cord-345222-otfnrarh 707 18 in in IN cord-345222-otfnrarh 707 19 cholera cholera NN cord-345222-otfnrarh 707 20 during during IN cord-345222-otfnrarh 707 21 intestinal intestinal JJ cord-345222-otfnrarh 707 22 perfusion perfusion NN cord-345222-otfnrarh 707 23 with with IN cord-345222-otfnrarh 707 24 glucose glucose NN cord-345222-otfnrarh 707 25 - - HYPH cord-345222-otfnrarh 707 26 containing contain VBG cord-345222-otfnrarh 707 27 solutions solution NNS cord-345222-otfnrarh 707 28 Replacement replacement NN cord-345222-otfnrarh 707 29 of of IN cord-345222-otfnrarh 707 30 water water NN cord-345222-otfnrarh 707 31 and and CC cord-345222-otfnrarh 707 32 electrolyte electrolyte JJ cord-345222-otfnrarh 707 33 losses loss NNS cord-345222-otfnrarh 707 34 in in IN cord-345222-otfnrarh 707 35 cholera cholera NN cord-345222-otfnrarh 707 36 by by IN cord-345222-otfnrarh 707 37 an an DT cord-345222-otfnrarh 707 38 oral oral JJ cord-345222-otfnrarh 707 39 glucose glucose NN cord-345222-otfnrarh 707 40 - - HYPH cord-345222-otfnrarh 707 41 electrolyte electrolyte NN cord-345222-otfnrarh 707 42 solution solution NN cord-345222-otfnrarh 707 43 Randomized Randomized NNP cord-345222-otfnrarh 707 44 controlled control VBN cord-345222-otfnrarh 707 45 trial trial NN cord-345222-otfnrarh 707 46 comparing compare VBG cord-345222-otfnrarh 707 47 oral oral JJ cord-345222-otfnrarh 707 48 and and CC cord-345222-otfnrarh 707 49 intravenous intravenous JJ cord-345222-otfnrarh 707 50 rehydration rehydration NN cord-345222-otfnrarh 707 51 therapy therapy NN cord-345222-otfnrarh 707 52 in in IN cord-345222-otfnrarh 707 53 children child NNS cord-345222-otfnrarh 707 54 with with IN cord-345222-otfnrarh 707 55 diarrhea diarrhea JJ cord-345222-otfnrarh 707 56 Oral oral JJ cord-345222-otfnrarh 707 57 versus versus IN cord-345222-otfnrarh 707 58 intravenous intravenous JJ cord-345222-otfnrarh 707 59 rehydration rehydration NN cord-345222-otfnrarh 707 60 for for IN cord-345222-otfnrarh 707 61 treating treat VBG cord-345222-otfnrarh 707 62 dehydration dehydration NN cord-345222-otfnrarh 707 63 due due IN cord-345222-otfnrarh 707 64 to to IN cord-345222-otfnrarh 707 65 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 707 66 in in IN cord-345222-otfnrarh 707 67 children child NNS cord-345222-otfnrarh 707 68 Dehydration dehydration NN cord-345222-otfnrarh 707 69 and and CC cord-345222-otfnrarh 707 70 rehydration rehydration NN cord-345222-otfnrarh 707 71 . . . cord-345222-otfnrarh 708 1 State state NN cord-345222-otfnrarh 708 2 of of IN cord-345222-otfnrarh 708 3 the the DT cord-345222-otfnrarh 708 4 art art NN cord-345222-otfnrarh 708 5 and and CC cord-345222-otfnrarh 708 6 therapeutic therapeutic JJ cord-345222-otfnrarh 708 7 interventions intervention NNS cord-345222-otfnrarh 709 1 Giardia Giardia NNP cord-345222-otfnrarh 709 2 intestinalis intestinalis NNP cord-345222-otfnrarh 709 3 La La NNP cord-345222-otfnrarh 709 4 gastroenterite gastroenterite NNP cord-345222-otfnrarh 709 5 acuta acuta NNP cord-345222-otfnrarh 709 6 : : : cord-345222-otfnrarh 709 7 reidratazione reidratazione NNP cord-345222-otfnrarh 709 8 , , , cord-345222-otfnrarh 709 9 alimentazione alimentazione NNP cord-345222-otfnrarh 709 10 e e NNP cord-345222-otfnrarh 709 11 terapia terapia NNP cord-345222-otfnrarh 709 12 al al NNP cord-345222-otfnrarh 709 13 pronto pronto NNP cord-345222-otfnrarh 709 14 soccorso soccorso NNP cord-345222-otfnrarh 709 15 Evaluating evaluate VBG cord-345222-otfnrarh 709 16 the the DT cord-345222-otfnrarh 709 17 cost cost NN cord-345222-otfnrarh 709 18 utility utility NN cord-345222-otfnrarh 709 19 of of IN cord-345222-otfnrarh 709 20 racecadotril racecadotril NNP cord-345222-otfnrarh 709 21 for for IN cord-345222-otfnrarh 709 22 the the DT cord-345222-otfnrarh 709 23 treatment treatment NN cord-345222-otfnrarh 709 24 of of IN cord-345222-otfnrarh 709 25 acute acute JJ cord-345222-otfnrarh 709 26 watery watery JJ cord-345222-otfnrarh 709 27 diarrhea diarrhea NN cord-345222-otfnrarh 709 28 in in IN cord-345222-otfnrarh 709 29 children child NNS cord-345222-otfnrarh 709 30 : : : cord-345222-otfnrarh 709 31 the the DT cord-345222-otfnrarh 709 32 RAWD RAWD NNP cord-345222-otfnrarh 709 33 model model NN cord-345222-otfnrarh 709 34 Racecadotril Racecadotril NNP cord-345222-otfnrarh 709 35 for for IN cord-345222-otfnrarh 709 36 childhood childhood NN cord-345222-otfnrarh 709 37 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 709 38 : : : cord-345222-otfnrarh 709 39 an an DT cord-345222-otfnrarh 709 40 individual individual JJ cord-345222-otfnrarh 709 41 patient patient NN cord-345222-otfnrarh 709 42 data datum NNS cord-345222-otfnrarh 709 43 meta meta NNP cord-345222-otfnrarh 709 44 - - HYPH cord-345222-otfnrarh 709 45 analysis analysis NN cord-345222-otfnrarh 709 46 Racecadotril Racecadotril NNP cord-345222-otfnrarh 709 47 in in IN cord-345222-otfnrarh 709 48 the the DT cord-345222-otfnrarh 709 49 treatment treatment NN cord-345222-otfnrarh 709 50 of of IN cord-345222-otfnrarh 709 51 acute acute JJ cord-345222-otfnrarh 709 52 watery watery JJ cord-345222-otfnrarh 709 53 diarrhea diarrhea NN cord-345222-otfnrarh 709 54 in in IN cord-345222-otfnrarh 709 55 children child NNS cord-345222-otfnrarh 709 56 Efficacy Efficacy NNP cord-345222-otfnrarh 709 57 and and CC cord-345222-otfnrarh 709 58 tolerability tolerability NN cord-345222-otfnrarh 709 59 of of IN cord-345222-otfnrarh 709 60 racecadotril racecadotril NNP cord-345222-otfnrarh 709 61 in in IN cord-345222-otfnrarh 709 62 acute acute JJ cord-345222-otfnrarh 709 63 diarrhea diarrhea NN cord-345222-otfnrarh 709 64 in in IN cord-345222-otfnrarh 709 65 children child NNS cord-345222-otfnrarh 709 66 Ondansetron ondansetron RB cord-345222-otfnrarh 709 67 use use VB cord-345222-otfnrarh 709 68 in in IN cord-345222-otfnrarh 709 69 the the DT cord-345222-otfnrarh 709 70 pediatric pediatric JJ cord-345222-otfnrarh 709 71 emergency emergency NN cord-345222-otfnrarh 709 72 room room NN cord-345222-otfnrarh 709 73 for for IN cord-345222-otfnrarh 709 74 diagnoses diagnosis NNS cord-345222-otfnrarh 709 75 other other JJ cord-345222-otfnrarh 709 76 than than IN cord-345222-otfnrarh 709 77 acute acute JJ cord-345222-otfnrarh 709 78 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 709 79 Antiemetics antiemetic NNS cord-345222-otfnrarh 709 80 for for IN cord-345222-otfnrarh 709 81 reducing reduce VBG cord-345222-otfnrarh 709 82 vomiting vomiting NN cord-345222-otfnrarh 709 83 related relate VBN cord-345222-otfnrarh 709 84 to to IN cord-345222-otfnrarh 709 85 acute acute JJ cord-345222-otfnrarh 709 86 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 709 87 in in IN cord-345222-otfnrarh 709 88 children child NNS cord-345222-otfnrarh 709 89 and and CC cord-345222-otfnrarh 709 90 adolescents adolescent NNS cord-345222-otfnrarh 710 1 Oral oral JJ cord-345222-otfnrarh 710 2 ondansetron ondansetron NN cord-345222-otfnrarh 710 3 for for IN cord-345222-otfnrarh 710 4 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 710 5 in in IN cord-345222-otfnrarh 710 6 a a DT cord-345222-otfnrarh 710 7 pediatric pediatric JJ cord-345222-otfnrarh 710 8 emergency emergency NN cord-345222-otfnrarh 710 9 department department NN cord-345222-otfnrarh 711 1 A a DT cord-345222-otfnrarh 711 2 randomized randomized JJ cord-345222-otfnrarh 711 3 clinical clinical JJ cord-345222-otfnrarh 711 4 trial trial NN cord-345222-otfnrarh 711 5 comparing compare VBG cord-345222-otfnrarh 711 6 oral oral JJ cord-345222-otfnrarh 711 7 ondansetron ondansetron NN cord-345222-otfnrarh 711 8 with with IN cord-345222-otfnrarh 711 9 placebo placebo NN cord-345222-otfnrarh 711 10 in in IN cord-345222-otfnrarh 711 11 children child NNS cord-345222-otfnrarh 711 12 with with IN cord-345222-otfnrarh 711 13 vomiting vomit VBG cord-345222-otfnrarh 711 14 from from IN cord-345222-otfnrarh 711 15 acute acute JJ cord-345222-otfnrarh 711 16 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 711 17 Unedited Unedited NNP cord-345222-otfnrarh 711 18 Draft Draft NNP cord-345222-otfnrarh 711 19 Report Report NNP cord-345222-otfnrarh 711 20 of of IN cord-345222-otfnrarh 711 21 the the DT cord-345222-otfnrarh 711 22 17th 17th JJ cord-345222-otfnrarh 711 23 Expert Expert NNP cord-345222-otfnrarh 711 24 Committee Committee NNP cord-345222-otfnrarh 711 25 on on IN cord-345222-otfnrarh 711 26 the the DT cord-345222-otfnrarh 711 27 Selection Selection NNP cord-345222-otfnrarh 711 28 and and CC cord-345222-otfnrarh 711 29 Use Use NNP cord-345222-otfnrarh 711 30 of of IN cord-345222-otfnrarh 711 31 Essential Essential NNP cord-345222-otfnrarh 711 32 Medicines Medicines NNPS cord-345222-otfnrarh 711 33 . . . cord-345222-otfnrarh 712 1 Geneva Geneva NNP cord-345222-otfnrarh 712 2 : : : cord-345222-otfnrarh 713 1 WHO who WP cord-345222-otfnrarh 713 2 Discovery Discovery NNP cord-345222-otfnrarh 713 3 of of IN cord-345222-otfnrarh 713 4 human human JJ cord-345222-otfnrarh 713 5 zinc zinc NN cord-345222-otfnrarh 713 6 deficiency deficiency NN cord-345222-otfnrarh 713 7 : : : cord-345222-otfnrarh 713 8 50 50 CD cord-345222-otfnrarh 713 9 years year NNS cord-345222-otfnrarh 713 10 later later RB cord-345222-otfnrarh 713 11 Oral oral JJ cord-345222-otfnrarh 713 12 zinc zinc NN cord-345222-otfnrarh 713 13 for for IN cord-345222-otfnrarh 713 14 treating treat VBG cord-345222-otfnrarh 713 15 diarrhoea diarrhoea NN cord-345222-otfnrarh 713 16 in in IN cord-345222-otfnrarh 713 17 children child NNS cord-345222-otfnrarh 713 18 Zinc zinc NN cord-345222-otfnrarh 713 19 and and CC cord-345222-otfnrarh 713 20 diarrhea diarrhea NN cord-345222-otfnrarh 713 21 in in IN cord-345222-otfnrarh 713 22 children child NNS cord-345222-otfnrarh 713 23 under under IN cord-345222-otfnrarh 713 24 5 5 CD cord-345222-otfnrarh 713 25 years year NNS cord-345222-otfnrarh 713 26 : : : cord-345222-otfnrarh 714 1 WHO who WP cord-345222-otfnrarh 714 2 recommendations recommendation NNS cord-345222-otfnrarh 714 3 implemented implement VBN cord-345222-otfnrarh 714 4 in in IN cord-345222-otfnrarh 714 5 Switzerland Switzerland NNP cord-345222-otfnrarh 714 6 Probiotics Probiotics NNPS cord-345222-otfnrarh 714 7 for for IN cord-345222-otfnrarh 714 8 treating treat VBG cord-345222-otfnrarh 714 9 infectious infectious JJ cord-345222-otfnrarh 714 10 diarrhoea diarrhoea NN cord-345222-otfnrarh 714 11 Probiotics probiotic NNS cord-345222-otfnrarh 714 12 and and CC cord-345222-otfnrarh 714 13 prebiotics prebiotic NNS cord-345222-otfnrarh 714 14 in in IN cord-345222-otfnrarh 714 15 pediatrics pediatric NNS cord-345222-otfnrarh 714 16 : : : cord-345222-otfnrarh 714 17 where where WRB cord-345222-otfnrarh 714 18 are be VBP cord-345222-otfnrarh 714 19 we -PRON- PRP cord-345222-otfnrarh 714 20 now now RB cord-345222-otfnrarh 714 21 ? ? . cord-345222-otfnrarh 715 1 Meta Meta NNP cord-345222-otfnrarh 715 2 - - HYPH cord-345222-otfnrarh 715 3 analysis analysis NN cord-345222-otfnrarh 715 4 : : : cord-345222-otfnrarh 716 1 Saccharomyces saccharomyce NNS cord-345222-otfnrarh 716 2 boulardii boulardii VBD cord-345222-otfnrarh 716 3 for for IN cord-345222-otfnrarh 716 4 treating treat VBG cord-345222-otfnrarh 716 5 acute acute JJ cord-345222-otfnrarh 716 6 diarrhoea diarrhoea NN cord-345222-otfnrarh 716 7 in in IN cord-345222-otfnrarh 716 8 children child NNS cord-345222-otfnrarh 717 1 Randomised randomised JJ cord-345222-otfnrarh 717 2 clinical clinical JJ cord-345222-otfnrarh 717 3 trial trial NN cord-345222-otfnrarh 717 4 : : : cord-345222-otfnrarh 718 1 Lactobacillus lactobacillus NN cord-345222-otfnrarh 718 2 reuteri reuteri NN cord-345222-otfnrarh 718 3 DSM DSM NNP cord-345222-otfnrarh 718 4 17938 17938 CD cord-345222-otfnrarh 718 5 vs vs IN cord-345222-otfnrarh 718 6 placebo placebo NN cord-345222-otfnrarh 718 7 in in IN cord-345222-otfnrarh 718 8 children child NNS cord-345222-otfnrarh 718 9 with with IN cord-345222-otfnrarh 718 10 acute acute JJ cord-345222-otfnrarh 718 11 diarrhoea diarrhoea NN cord-345222-otfnrarh 718 12 -a -a HYPH cord-345222-otfnrarh 718 13 double double JJ cord-345222-otfnrarh 718 14 - - HYPH cord-345222-otfnrarh 718 15 blind blind JJ cord-345222-otfnrarh 718 16 study study NN cord-345222-otfnrarh 718 17 Health Health NNP cord-345222-otfnrarh 718 18 impact impact NN cord-345222-otfnrarh 718 19 of of IN cord-345222-otfnrarh 718 20 probiotics probiotic NNS cord-345222-otfnrarh 718 21 -vision -vision : cord-345222-otfnrarh 718 22 and and CC cord-345222-otfnrarh 718 23 opportunities opportunitie VBZ cord-345222-otfnrarh 718 24 Probiotics probiotic NNS cord-345222-otfnrarh 718 25 for for IN cord-345222-otfnrarh 718 26 children child NNS cord-345222-otfnrarh 718 27 with with IN cord-345222-otfnrarh 718 28 diarrhea diarrhea NN cord-345222-otfnrarh 718 29 : : : cord-345222-otfnrarh 718 30 an an DT cord-345222-otfnrarh 718 31 update update NN cord-345222-otfnrarh 718 32 Probiotic probiotic JJ cord-345222-otfnrarh 718 33 Lactobacillus lactobacillus NN cord-345222-otfnrarh 718 34 reuteri reuteri NN cord-345222-otfnrarh 718 35 suppress suppress VB cord-345222-otfnrarh 718 36 proinflammatory proinflammatory JJ cord-345222-otfnrarh 718 37 cytokines cytokine NNS cord-345222-otfnrarh 718 38 via via IN cord-345222-otfnrarh 718 39 c c NN cord-345222-otfnrarh 718 40 - - : cord-345222-otfnrarh 718 41 Jun Jun NNP cord-345222-otfnrarh 718 42 Histamine Histamine NNP cord-345222-otfnrarh 718 43 derived derive VBN cord-345222-otfnrarh 718 44 from from IN cord-345222-otfnrarh 718 45 probiotic probiotic JJ cord-345222-otfnrarh 718 46 Lactobacillus lactobacillus NN cord-345222-otfnrarh 718 47 reuteri reuteri NN cord-345222-otfnrarh 719 1 suppresses suppress VBZ cord-345222-otfnrarh 719 2 TNF TNF NNP cord-345222-otfnrarh 719 3 via via IN cord-345222-otfnrarh 719 4 modulation modulation NN cord-345222-otfnrarh 719 5 of of IN cord-345222-otfnrarh 719 6 PKA PKA NNP cord-345222-otfnrarh 719 7 and and CC cord-345222-otfnrarh 719 8 ERK ERK NNP cord-345222-otfnrarh 719 9 signaling signal VBG cord-345222-otfnrarh 719 10 Acute acute JJ cord-345222-otfnrarh 719 11 gastroenteritis gastroenteritis NN cord-345222-otfnrarh 719 12 in in IN cord-345222-otfnrarh 719 13 children child NNS cord-345222-otfnrarh 719 14 : : : cord-345222-otfnrarh 719 15 what what WDT cord-345222-otfnrarh 719 16 role role NN cord-345222-otfnrarh 719 17 for for IN cord-345222-otfnrarh 719 18 antibacterials antibacterial NNS cord-345222-otfnrarh 719 19 ? ? . cord-345222-otfnrarh 720 1 Antimicrobials antimicrobial NNS cord-345222-otfnrarh 720 2 for for IN cord-345222-otfnrarh 720 3 treating treat VBG cord-345222-otfnrarh 720 4 symptomatic symptomatic JJ cord-345222-otfnrarh 720 5 non non JJ cord-345222-otfnrarh 720 6 - - JJ cord-345222-otfnrarh 720 7 typhoidal typhoidal JJ cord-345222-otfnrarh 720 8 Salmonella Salmonella NNP cord-345222-otfnrarh 720 9 infection infection NN cord-345222-otfnrarh 721 1 The the DT cord-345222-otfnrarh 721 2 patient patient NN cord-345222-otfnrarh 721 3 presenting present VBG cord-345222-otfnrarh 721 4 with with IN cord-345222-otfnrarh 721 5 acute acute JJ cord-345222-otfnrarh 721 6 dysentery dysentery NN cord-345222-otfnrarh 721 7 -a -a HYPH cord-345222-otfnrarh 721 8 systematic systematic JJ cord-345222-otfnrarh 721 9 review review NN cord-345222-otfnrarh 721 10 Infections infection NNS cord-345222-otfnrarh 721 11 following follow VBG cord-345222-otfnrarh 721 12 the the DT cord-345222-otfnrarh 721 13 application application NN cord-345222-otfnrarh 721 14 of of IN cord-345222-otfnrarh 721 15 leeches leech NNS cord-345222-otfnrarh 721 16 : : : cord-345222-otfnrarh 721 17 two two CD cord-345222-otfnrarh 721 18 case case NN cord-345222-otfnrarh 721 19 reports report NNS cord-345222-otfnrarh 721 20 and and CC cord-345222-otfnrarh 721 21 review review NN cord-345222-otfnrarh 721 22 of of IN cord-345222-otfnrarh 721 23 the the DT cord-345222-otfnrarh 721 24 literature literature NN cord-345222-otfnrarh 722 1 The the DT cord-345222-otfnrarh 722 2 role role NN cord-345222-otfnrarh 722 3 of of IN cord-345222-otfnrarh 722 4 leech leech NN cord-345222-otfnrarh 722 5 water water NN cord-345222-otfnrarh 722 6 sampling sampling NN cord-345222-otfnrarh 722 7 in in IN cord-345222-otfnrarh 722 8 choice choice NN cord-345222-otfnrarh 722 9 of of IN cord-345222-otfnrarh 722 10 prophylactic prophylactic JJ cord-345222-otfnrarh 722 11 antibiotics antibiotic NNS cord-345222-otfnrarh 722 12 in in IN cord-345222-otfnrarh 722 13 medical medical JJ cord-345222-otfnrarh 722 14 leech leech NN cord-345222-otfnrarh 722 15 therapy therapy NN cord-345222-otfnrarh 722 16 . . . cord-345222-otfnrarh 723 1 Microsurgery Microsurgery NNP cord-345222-otfnrarh 723 2 Empiric Empiric NNP cord-345222-otfnrarh 723 3 antimicrobial antimicrobial JJ cord-345222-otfnrarh 723 4 therapy therapy NN cord-345222-otfnrarh 723 5 and and CC cord-345222-otfnrarh 723 6 infectious infectious JJ cord-345222-otfnrarh 723 7 diarrhea diarrhea NN cord-345222-otfnrarh 723 8 . . . cord-345222-otfnrarh 724 1 Do do VBP cord-345222-otfnrarh 724 2 we -PRON- PRP cord-345222-otfnrarh 724 3 need need VB cord-345222-otfnrarh 724 4 local local JJ cord-345222-otfnrarh 724 5 guidelines guideline NNS cord-345222-otfnrarh 724 6 ? ? . cord-345222-otfnrarh 725 1 Resistance resistance NN cord-345222-otfnrarh 725 2 mechanisms mechanism NNS cord-345222-otfnrarh 725 3 in in IN cord-345222-otfnrarh 725 4 Campylobacter Campylobacter NNP cord-345222-otfnrarh 725 5 jejuni jejuni NNP cord-345222-otfnrarh 725 6 Clostridium clostridium NN cord-345222-otfnrarh 725 7 difficile difficile NN cord-345222-otfnrarh 725 8 : : : cord-345222-otfnrarh 725 9 an an DT cord-345222-otfnrarh 725 10 emerging emerge VBG cord-345222-otfnrarh 725 11 pathogen pathogen NN cord-345222-otfnrarh 725 12 in in IN cord-345222-otfnrarh 725 13 children child NNS cord-345222-otfnrarh 726 1 Potential potential JJ cord-345222-otfnrarh 726 2 protective protective JJ cord-345222-otfnrarh 726 3 role role NN cord-345222-otfnrarh 726 4 of of IN cord-345222-otfnrarh 726 5 linezolid linezolid NNP cord-345222-otfnrarh 726 6 against against IN cord-345222-otfnrarh 726 7 Clostridium clostridium NN cord-345222-otfnrarh 726 8 difficile difficile NN cord-345222-otfnrarh 726 9 infection infection NN cord-345222-otfnrarh 726 10 Fidaxomicin Fidaxomicin NNP cord-345222-otfnrarh 726 11 for for IN cord-345222-otfnrarh 726 12 the the DT cord-345222-otfnrarh 726 13 treatment treatment NN cord-345222-otfnrarh 726 14 of of IN cord-345222-otfnrarh 726 15 Clostridium clostridium NN cord-345222-otfnrarh 726 16 difficile difficile NN cord-345222-otfnrarh 726 17 infections infection NNS cord-345222-otfnrarh 726 18 Clostridium clostridium NN cord-345222-otfnrarh 726 19 difficile difficile NN cord-345222-otfnrarh 726 20 infection infection NN cord-345222-otfnrarh 726 21 : : : cord-345222-otfnrarh 726 22 new new JJ cord-345222-otfnrarh 726 23 insights insight NNS cord-345222-otfnrarh 726 24 into into IN cord-345222-otfnrarh 726 25 management management NN cord-345222-otfnrarh 726 26 Clostridium clostridium NN cord-345222-otfnrarh 726 27 difficile difficile NN cord-345222-otfnrarh 726 28 : : : cord-345222-otfnrarh 726 29 development development NN cord-345222-otfnrarh 726 30 of of IN cord-345222-otfnrarh 726 31 a a DT cord-345222-otfnrarh 726 32 novel novel JJ cord-345222-otfnrarh 726 33 candidate candidate NN cord-345222-otfnrarh 726 34 vaccine vaccine NN cord-345222-otfnrarh 726 35 Bacterial bacterial JJ cord-345222-otfnrarh 726 36 enteropathogens enteropathogen NNS cord-345222-otfnrarh 726 37 and and CC cord-345222-otfnrarh 726 38 risk risk NN cord-345222-otfnrarh 726 39 factors factor NNS cord-345222-otfnrarh 726 40 associated associate VBN cord-345222-otfnrarh 726 41 with with IN cord-345222-otfnrarh 726 42 childhood childhood NN cord-345222-otfnrarh 726 43 diarrhea diarrhea NN cord-345222-otfnrarh 726 44 Enteropathogenic Enteropathogenic NNP cord-345222-otfnrarh 726 45 Escherichia Escherichia NNP cord-345222-otfnrarh 726 46 coli coli NNS cord-345222-otfnrarh 726 47 associated associate VBN cord-345222-otfnrarh 726 48 with with IN cord-345222-otfnrarh 726 49 diarrhea diarrhea NN cord-345222-otfnrarh 726 50 in in IN cord-345222-otfnrarh 726 51 children child NNS cord-345222-otfnrarh 726 52 in in IN cord-345222-otfnrarh 726 53 Cairo Cairo NNP cord-345222-otfnrarh 726 54 Enteropathogenic Enteropathogenic NNP cord-345222-otfnrarh 726 55 Escherichia Escherichia NNP cord-345222-otfnrarh 726 56 coli coli VBZ cord-345222-otfnrarh 726 57 infection infection NN cord-345222-otfnrarh 726 58 in in IN cord-345222-otfnrarh 726 59 children child NNS cord-345222-otfnrarh 727 1 New new JJ cord-345222-otfnrarh 727 2 developments development NNS cord-345222-otfnrarh 727 3 in in IN cord-345222-otfnrarh 727 4 traveler traveler NN cord-345222-otfnrarh 727 5 's 's POS cord-345222-otfnrarh 727 6 diarrhea diarrhea NN cord-345222-otfnrarh 728 1 Different different JJ cord-345222-otfnrarh 728 2 classes class NNS cord-345222-otfnrarh 728 3 of of IN cord-345222-otfnrarh 728 4 antibiotics antibiotic NNS cord-345222-otfnrarh 728 5 differentially differentially RB cord-345222-otfnrarh 728 6 influence influence VBP cord-345222-otfnrarh 728 7 shiga shiga NNP cord-345222-otfnrarh 728 8 toxin toxin NNP cord-345222-otfnrarh 728 9 production production NN cord-345222-otfnrarh 728 10 Association Association NNP cord-345222-otfnrarh 728 11 between between IN cord-345222-otfnrarh 728 12 azithromycin azithromycin NNP cord-345222-otfnrarh 728 13 therapy therapy NN cord-345222-otfnrarh 728 14 and and CC cord-345222-otfnrarh 728 15 duration duration NN cord-345222-otfnrarh 728 16 of of IN cord-345222-otfnrarh 728 17 bacterial bacterial JJ cord-345222-otfnrarh 728 18 shedding shedding NN cord-345222-otfnrarh 728 19 among among IN cord-345222-otfnrarh 728 20 patients patient NNS cord-345222-otfnrarh 728 21 with with IN cord-345222-otfnrarh 728 22 Shiga Shiga NNP cord-345222-otfnrarh 728 23 toxin toxin NN cord-345222-otfnrarh 728 24 - - HYPH cord-345222-otfnrarh 728 25 producing produce VBG cord-345222-otfnrarh 728 26 enteroaggregative enteroaggregative JJ cord-345222-otfnrarh 728 27 Escherichia Escherichia NNP cord-345222-otfnrarh 728 28 coli coli VBZ cord-345222-otfnrarh 728 29 O104 o104 CD cord-345222-otfnrarh 728 30 : : : cord-345222-otfnrarh 729 1 H4 H4 NNP cord-345222-otfnrarh 729 2 Lessons Lessons NNP cord-345222-otfnrarh 729 3 learned learn VBD cord-345222-otfnrarh 729 4 from from IN cord-345222-otfnrarh 729 5 outbreaks outbreak NNS cord-345222-otfnrarh 729 6 of of IN cord-345222-otfnrarh 729 7 Shiga Shiga NNP cord-345222-otfnrarh 729 8 toxin toxin NN cord-345222-otfnrarh 729 9 producing produce VBG cord-345222-otfnrarh 729 10 Escherichia Escherichia NNP cord-345222-otfnrarh 729 11 coli coli VBZ cord-345222-otfnrarh 729 12 Antagonistic antagonistic JJ cord-345222-otfnrarh 729 13 effects effect NNS cord-345222-otfnrarh 729 14 of of IN cord-345222-otfnrarh 729 15 probiotic probiotic JJ cord-345222-otfnrarh 729 16 Escherichia Escherichia NNP cord-345222-otfnrarh 729 17 coli coli NNS cord-345222-otfnrarh 729 18 Nissle Nissle NNP cord-345222-otfnrarh 729 19 1917 1917 CD cord-345222-otfnrarh 729 20 on on IN cord-345222-otfnrarh 729 21 EHEC EHEC NNP cord-345222-otfnrarh 729 22 strains strain NNS cord-345222-otfnrarh 729 23 of of IN cord-345222-otfnrarh 729 24 serotype serotype NN cord-345222-otfnrarh 729 25 O104 o104 NN cord-345222-otfnrarh 729 26 : : : cord-345222-otfnrarh 729 27 H4 H4 NNP cord-345222-otfnrarh 729 28 and and CC cord-345222-otfnrarh 729 29 O157 O157 NNP cord-345222-otfnrarh 729 30 : : : cord-345222-otfnrarh 730 1 H7 H7 NNP cord-345222-otfnrarh 730 2 Escherichia Escherichia NNP cord-345222-otfnrarh 730 3 coli coli NNS cord-345222-otfnrarh 730 4 : : : cord-345222-otfnrarh 730 5 great great JJ cord-345222-otfnrarh 730 6 diversity diversity NN cord-345222-otfnrarh 730 7 around around IN cord-345222-otfnrarh 730 8 a a DT cord-345222-otfnrarh 730 9 common common JJ cord-345222-otfnrarh 730 10 core core NN cord-345222-otfnrarh 730 11 Probiotics probiotic NNS cord-345222-otfnrarh 730 12 for for IN cord-345222-otfnrarh 730 13 the the DT cord-345222-otfnrarh 730 14 treatment treatment NN cord-345222-otfnrarh 730 15 of of IN cord-345222-otfnrarh 730 16 pediatric pediatric JJ cord-345222-otfnrarh 730 17 Helicobacter Helicobacter NNP cord-345222-otfnrarh 730 18 pylori pylori NN cord-345222-otfnrarh 730 19 infection infection NN cord-345222-otfnrarh 730 20 : : : cord-345222-otfnrarh 730 21 a a DT cord-345222-otfnrarh 730 22 randomized randomized JJ cord-345222-otfnrarh 730 23 double double JJ cord-345222-otfnrarh 730 24 blind blind JJ cord-345222-otfnrarh 730 25 clinical clinical JJ cord-345222-otfnrarh 730 26 trial trial NN cord-345222-otfnrarh 730 27 Childhood Childhood NNP cord-345222-otfnrarh 730 28 and and CC cord-345222-otfnrarh 730 29 Coress Coress NNP cord-345222-otfnrarh 730 30 model model NN cord-345222-otfnrarh 730 31 of of IN cord-345222-otfnrarh 730 32 carcinogenesis carcinogenesis NN cord-345222-otfnrarh 730 33 Risk risk NN cord-345222-otfnrarh 730 34 of of IN cord-345222-otfnrarh 730 35 recurrent recurrent JJ cord-345222-otfnrarh 730 36 Helicobacter Helicobacter NNP cord-345222-otfnrarh 730 37 pylori pylori NN cord-345222-otfnrarh 730 38 infection infection NN cord-345222-otfnrarh 730 39 1 1 CD cord-345222-otfnrarh 730 40 year year NN cord-345222-otfnrarh 730 41 after after IN cord-345222-otfnrarh 730 42 initial initial JJ cord-345222-otfnrarh 730 43 eradication eradication NN cord-345222-otfnrarh 730 44 therapy therapy NN cord-345222-otfnrarh 730 45 in in IN cord-345222-otfnrarh 730 46 7 7 CD cord-345222-otfnrarh 730 47 Latin latin JJ cord-345222-otfnrarh 730 48 American american JJ cord-345222-otfnrarh 730 49 communities community NNS cord-345222-otfnrarh 730 50 World World NNP cord-345222-otfnrarh 730 51 Health Health NNP cord-345222-otfnrarh 730 52 Organization Organization NNP cord-345222-otfnrarh 730 53 . . . cord-345222-otfnrarh 731 1 Guidelines guideline NNS cord-345222-otfnrarh 731 2 for for IN cord-345222-otfnrarh 731 3 the the DT cord-345222-otfnrarh 731 4 Control Control NNP cord-345222-otfnrarh 731 5 of of IN cord-345222-otfnrarh 731 6 Shigellosis Shigellosis NNP cord-345222-otfnrarh 731 7 , , , cord-345222-otfnrarh 731 8 Including include VBG cord-345222-otfnrarh 731 9 the the DT cord-345222-otfnrarh 731 10 Epidemics epidemic NNS cord-345222-otfnrarh 731 11 Which which WDT cord-345222-otfnrarh 731 12 Were be VBD cord-345222-otfnrarh 731 13 Caused cause VBN cord-345222-otfnrarh 731 14 by by IN cord-345222-otfnrarh 731 15 Shigella Shigella NNP cord-345222-otfnrarh 731 16 dysenteriae dysenteriae NN cord-345222-otfnrarh 731 17 Type Type NNP cord-345222-otfnrarh 731 18 1 1 CD cord-345222-otfnrarh 731 19 . . . cord-345222-otfnrarh 732 1 Geneva Geneva NNP cord-345222-otfnrarh 732 2 : : : cord-345222-otfnrarh 732 3 WHO who WP cord-345222-otfnrarh 732 4 Antibiotic antibiotic JJ cord-345222-otfnrarh 732 5 therapy therapy NN cord-345222-otfnrarh 732 6 for for IN cord-345222-otfnrarh 732 7 Shigella Shigella NNP cord-345222-otfnrarh 732 8 dysentery dysentery NN cord-345222-otfnrarh 732 9 A a DT cord-345222-otfnrarh 732 10 multi multi JJ cord-345222-otfnrarh 732 11 centre centre NN cord-345222-otfnrarh 732 12 study study NN cord-345222-otfnrarh 732 13 of of IN cord-345222-otfnrarh 732 14 Shigella Shigella NNP cord-345222-otfnrarh 732 15 diarrhoea diarrhoea NN cord-345222-otfnrarh 732 16 in in IN cord-345222-otfnrarh 732 17 six six CD cord-345222-otfnrarh 732 18 Asian asian JJ cord-345222-otfnrarh 732 19 countries country NNS cord-345222-otfnrarh 732 20 : : : cord-345222-otfnrarh 732 21 disease disease NN cord-345222-otfnrarh 732 22 burden burden NN cord-345222-otfnrarh 732 23 , , , cord-345222-otfnrarh 732 24 clinical clinical JJ cord-345222-otfnrarh 732 25 manifestations manifestation NNS cord-345222-otfnrarh 732 26 , , , cord-345222-otfnrarh 732 27 and and CC cord-345222-otfnrarh 732 28 microbiology microbiology NN cord-345222-otfnrarh 733 1 The the DT cord-345222-otfnrarh 733 2 recent recent JJ cord-345222-otfnrarh 733 3 trends trend NNS cord-345222-otfnrarh 733 4 of of IN cord-345222-otfnrarh 733 5 shigellosis shigellosis NN cord-345222-otfnrarh 733 6 : : : cord-345222-otfnrarh 733 7 a a DT cord-345222-otfnrarh 733 8 JIPMER JIPMER NNP cord-345222-otfnrarh 733 9 perspective perspective NN cord-345222-otfnrarh 733 10 Broadly broadly RB cord-345222-otfnrarh 733 11 protective protective JJ cord-345222-otfnrarh 733 12 Shigella Shigella NNP cord-345222-otfnrarh 733 13 vaccine vaccine NN cord-345222-otfnrarh 733 14 based base VBN cord-345222-otfnrarh 733 15 on on IN cord-345222-otfnrarh 733 16 type type NN cord-345222-otfnrarh 733 17 III iii CD cord-345222-otfnrarh 733 18 secretion secretion NN cord-345222-otfnrarh 733 19 apparatus apparatus NN cord-345222-otfnrarh 733 20 proteins protein VBZ cord-345222-otfnrarh 733 21 Cholera cholera NN cord-345222-otfnrarh 733 22 epidemiology epidemiology NN cord-345222-otfnrarh 733 23 in in IN cord-345222-otfnrarh 733 24 Nigeria Nigeria NNP cord-345222-otfnrarh 733 25 : : : cord-345222-otfnrarh 733 26 an an DT cord-345222-otfnrarh 733 27 overview overview NN cord-345222-otfnrarh 734 1 Increasing increase VBG cord-345222-otfnrarh 734 2 antimicrobial antimicrobial JJ cord-345222-otfnrarh 734 3 resistance resistance NN cord-345222-otfnrarh 734 4 of of IN cord-345222-otfnrarh 734 5 Vibrio Vibrio NNP cord-345222-otfnrarh 734 6 cholerae cholerae NN cord-345222-otfnrarh 734 7 OI OI NNP cord-345222-otfnrarh 734 8 biotype biotype NN cord-345222-otfnrarh 734 9 E1 e1 NN cord-345222-otfnrarh 734 10 tor tor NN cord-345222-otfnrarh 734 11 strains strain NNS cord-345222-otfnrarh 734 12 isolated isolate VBN cord-345222-otfnrarh 734 13 in in IN cord-345222-otfnrarh 734 14 a a DT cord-345222-otfnrarh 734 15 tertiary tertiary JJ cord-345222-otfnrarh 734 16 - - HYPH cord-345222-otfnrarh 734 17 care care NN cord-345222-otfnrarh 734 18 centre centre NN cord-345222-otfnrarh 734 19 in in IN cord-345222-otfnrarh 734 20 India India NNP cord-345222-otfnrarh 734 21 Symptoms symptom NNS cord-345222-otfnrarh 734 22 and and CC cord-345222-otfnrarh 734 23 sources source NNS cord-345222-otfnrarh 734 24 of of IN cord-345222-otfnrarh 734 25 Yersinia Yersinia NNP cord-345222-otfnrarh 734 26 enterocolitica enterocolitica NNP cord-345222-otfnrarh 734 27 - - HYPH cord-345222-otfnrarh 734 28 infection infection NN cord-345222-otfnrarh 734 29 : : : cord-345222-otfnrarh 734 30 a a DT cord-345222-otfnrarh 734 31 case case NN cord-345222-otfnrarh 734 32 - - HYPH cord-345222-otfnrarh 734 33 control control NN cord-345222-otfnrarh 734 34 study study NN cord-345222-otfnrarh 734 35 Clinical clinical JJ cord-345222-otfnrarh 734 36 characteristics characteristic NNS cord-345222-otfnrarh 734 37 and and CC cord-345222-otfnrarh 734 38 response response NN cord-345222-otfnrarh 734 39 to to IN cord-345222-otfnrarh 734 40 prophylactic prophylactic JJ cord-345222-otfnrarh 734 41 fluconazole fluconazole NN cord-345222-otfnrarh 734 42 of of IN cord-345222-otfnrarh 734 43 preterm preterm JJ cord-345222-otfnrarh 734 44 VLBW VLBW NNP cord-345222-otfnrarh 734 45 neonates neonate NNS cord-345222-otfnrarh 734 46 with with IN cord-345222-otfnrarh 734 47 baseline baseline NN cord-345222-otfnrarh 734 48 and and CC cord-345222-otfnrarh 734 49 acquired acquire VBD cord-345222-otfnrarh 734 50 fungal fungal JJ cord-345222-otfnrarh 734 51 colonisation colonisation NN cord-345222-otfnrarh 734 52 in in IN cord-345222-otfnrarh 734 53 NICU NICU NNP cord-345222-otfnrarh 734 54 : : : cord-345222-otfnrarh 735 1 data datum NNS cord-345222-otfnrarh 735 2 from from IN cord-345222-otfnrarh 735 3 a a DT cord-345222-otfnrarh 735 4 multicentre multicentre JJ cord-345222-otfnrarh 735 5 RCT RCT NNP cord-345222-otfnrarh 736 1 Why why WRB cord-345222-otfnrarh 736 2 might may MD cord-345222-otfnrarh 736 3 micafungin micafungin NNP cord-345222-otfnrarh 736 4 be be VB cord-345222-otfnrarh 736 5 the the DT cord-345222-otfnrarh 736 6 drug drug NN cord-345222-otfnrarh 736 7 of of IN cord-345222-otfnrarh 736 8 choice choice NN cord-345222-otfnrarh 736 9 in in IN cord-345222-otfnrarh 736 10 pediatric pediatric JJ cord-345222-otfnrarh 736 11 patients patient NNS cord-345222-otfnrarh 736 12 ? ? . cord-345222-otfnrarh 737 1 Population population NN cord-345222-otfnrarh 737 2 pharmacokinetics pharmacokinetic NNS cord-345222-otfnrarh 737 3 of of IN cord-345222-otfnrarh 737 4 micafungin micafungin NNP cord-345222-otfnrarh 737 5 in in IN cord-345222-otfnrarh 737 6 neonates neonate NNS cord-345222-otfnrarh 737 7 and and CC cord-345222-otfnrarh 737 8 young young JJ cord-345222-otfnrarh 737 9 infants infant NNS cord-345222-otfnrarh 738 1 Scientific scientific JJ cord-345222-otfnrarh 738 2 evidence evidence NN cord-345222-otfnrarh 738 3 supporting support VBG cord-345222-otfnrarh 738 4 the the DT cord-345222-otfnrarh 738 5 use use NN cord-345222-otfnrarh 738 6 of of IN cord-345222-otfnrarh 738 7 micafungin micafungin NNP cord-345222-otfnrarh 738 8 in in IN cord-345222-otfnrarh 738 9 the the DT cord-345222-otfnrarh 738 10 treatment treatment NN cord-345222-otfnrarh 738 11 of of IN cord-345222-otfnrarh 738 12 invasive invasive JJ cord-345222-otfnrarh 738 13 candidiasis candidiasis NN cord-345222-otfnrarh 738 14 Echinocandins Echinocandins NNP cord-345222-otfnrarh 738 15 for for IN cord-345222-otfnrarh 738 16 the the DT cord-345222-otfnrarh 738 17 nursery nursery NN cord-345222-otfnrarh 738 18 : : : cord-345222-otfnrarh 738 19 an an DT cord-345222-otfnrarh 738 20 update update NN cord-345222-otfnrarh 738 21 Micafungin Micafungin NNP cord-345222-otfnrarh 738 22 : : : cord-345222-otfnrarh 738 23 a a DT cord-345222-otfnrarh 738 24 review review NN cord-345222-otfnrarh 738 25 of of IN cord-345222-otfnrarh 738 26 its -PRON- PRP$ cord-345222-otfnrarh 738 27 use use NN cord-345222-otfnrarh 738 28 in in IN cord-345222-otfnrarh 738 29 the the DT cord-345222-otfnrarh 738 30 prophylaxis prophylaxis NN cord-345222-otfnrarh 738 31 and and CC cord-345222-otfnrarh 738 32 treatment treatment NN cord-345222-otfnrarh 738 33 of of IN cord-345222-otfnrarh 738 34 invasive invasive JJ cord-345222-otfnrarh 738 35 Candida Candida NNP cord-345222-otfnrarh 738 36 infections infection NNS cord-345222-otfnrarh 739 1 Reprofiled reprofiled JJ cord-345222-otfnrarh 739 2 drug drug NN cord-345222-otfnrarh 739 3 targets target VBZ cord-345222-otfnrarh 739 4 ancient ancient JJ cord-345222-otfnrarh 739 5 protozoans protozoan NNS cord-345222-otfnrarh 739 6 : : : cord-345222-otfnrarh 739 7 drug drug NN cord-345222-otfnrarh 739 8 discovery discovery NN cord-345222-otfnrarh 739 9 for for IN cord-345222-otfnrarh 739 10 parasitic parasitic JJ cord-345222-otfnrarh 739 11 diarrheal diarrheal JJ cord-345222-otfnrarh 739 12 diseases disease NNS cord-345222-otfnrarh 740 1 Nitazoxanide Nitazoxanide NNP cord-345222-otfnrarh 740 2 for for IN cord-345222-otfnrarh 740 3 the the DT cord-345222-otfnrarh 740 4 empiric empiric JJ cord-345222-otfnrarh 740 5 treatment treatment NN cord-345222-otfnrarh 740 6 of of IN cord-345222-otfnrarh 740 7 pediatric pediatric JJ cord-345222-otfnrarh 740 8 infectious infectious JJ cord-345222-otfnrarh 740 9 diarrhea diarrhea NN cord-345222-otfnrarh 740 10 Drugs drug NNS cord-345222-otfnrarh 740 11 for for IN cord-345222-otfnrarh 740 12 treating treat VBG cord-345222-otfnrarh 740 13 giardiasis giardiasis NN cord-345222-otfnrarh 740 14 A a DT cord-345222-otfnrarh 740 15 reprofiled reprofile VBN cord-345222-otfnrarh 740 16 drug drug NN cord-345222-otfnrarh 740 17 , , , cord-345222-otfnrarh 740 18 auranofin auranofin NNP cord-345222-otfnrarh 740 19 , , , cord-345222-otfnrarh 740 20 is be VBZ cord-345222-otfnrarh 740 21 effective effective JJ cord-345222-otfnrarh 740 22 against against IN cord-345222-otfnrarh 740 23 metronidazole metronidazole NN cord-345222-otfnrarh 740 24 - - HYPH cord-345222-otfnrarh 740 25 resistant resistant JJ cord-345222-otfnrarh 740 26 Giardia Giardia NNP cord-345222-otfnrarh 740 27 lamblia lamblia NN cord-345222-otfnrarh 740 28 Current current JJ cord-345222-otfnrarh 740 29 pharmacotherapy pharmacotherapy NN cord-345222-otfnrarh 740 30 of of IN cord-345222-otfnrarh 740 31 amebiasis amebiasis NN cord-345222-otfnrarh 740 32 , , , cord-345222-otfnrarh 740 33 advances advance VBZ cord-345222-otfnrarh 740 34 in in IN cord-345222-otfnrarh 740 35 new new JJ cord-345222-otfnrarh 740 36 drugs drug NNS cord-345222-otfnrarh 740 37 , , , cord-345222-otfnrarh 740 38 and and CC cord-345222-otfnrarh 740 39 design design NN cord-345222-otfnrarh 740 40 of of IN cord-345222-otfnrarh 740 41 a a DT cord-345222-otfnrarh 740 42 vaccine vaccine NN cord-345222-otfnrarh 740 43 A a DT cord-345222-otfnrarh 740 44 research research NN cord-345222-otfnrarh 740 45 agenda agenda NN cord-345222-otfnrarh 740 46 for for IN cord-345222-otfnrarh 740 47 helminth helminth JJ cord-345222-otfnrarh 740 48 diseases disease NNS cord-345222-otfnrarh 740 49 of of IN cord-345222-otfnrarh 740 50 humans human NNS cord-345222-otfnrarh 740 51 : : : cord-345222-otfnrarh 740 52 intervention intervention NN cord-345222-otfnrarh 740 53 for for IN cord-345222-otfnrarh 740 54 control control NN cord-345222-otfnrarh 740 55 and and CC cord-345222-otfnrarh 740 56 elimination elimination NN cord-345222-otfnrarh 740 57 Efficacy Efficacy NNP cord-345222-otfnrarh 740 58 and and CC cord-345222-otfnrarh 740 59 safety safety NN cord-345222-otfnrarh 740 60 of of IN cord-345222-otfnrarh 740 61 nitazoxanide nitazoxanide NNP cord-345222-otfnrarh 740 62 , , , cord-345222-otfnrarh 740 63 albendazole albendazole NNP cord-345222-otfnrarh 740 64 , , , cord-345222-otfnrarh 740 65 and and CC cord-345222-otfnrarh 740 66 nitazoxanide nitazoxanide NN cord-345222-otfnrarh 740 67 - - HYPH cord-345222-otfnrarh 740 68 albendazole albendazole NN cord-345222-otfnrarh 740 69 against against IN cord-345222-otfnrarh 740 70 Trichuris Trichuris NNP cord-345222-otfnrarh 740 71 trichiura trichiura NN cord-345222-otfnrarh 740 72 infection infection NN cord-345222-otfnrarh 740 73 : : : cord-345222-otfnrarh 741 1 a a DT cord-345222-otfnrarh 741 2 randomized randomized JJ cord-345222-otfnrarh 741 3 controlled control VBN cord-345222-otfnrarh 741 4 trial trial NN cord-345222-otfnrarh 741 5 Submit submit VB cord-345222-otfnrarh 741 6 your -PRON- PRP$ cord-345222-otfnrarh 741 7 manuscript manuscript NN cord-345222-otfnrarh 741 8 here here RB cord-345222-otfnrarh 741 9 : : : cord-345222-otfnrarh 741 10 http://www.dovepress.com/infection-and-drug-resistance-journal http://www.dovepress.com/infection-and-drug-resistance-journal JJ cord-345222-otfnrarh 741 11 Infection Infection NNP cord-345222-otfnrarh 741 12 and and CC cord-345222-otfnrarh 741 13 Drug Drug NNP cord-345222-otfnrarh 741 14 Resistance Resistance NNP cord-345222-otfnrarh 741 15 is be VBZ cord-345222-otfnrarh 741 16 an an DT cord-345222-otfnrarh 741 17 international international JJ cord-345222-otfnrarh 741 18 , , , cord-345222-otfnrarh 741 19 peer peer NN cord-345222-otfnrarh 741 20 - - HYPH cord-345222-otfnrarh 741 21 reviewed review VBN cord-345222-otfnrarh 741 22 openaccess openaccess NNP cord-345222-otfnrarh 741 23 journal journal NNP cord-345222-otfnrarh 741 24 that that WDT cord-345222-otfnrarh 741 25 focuses focus VBZ cord-345222-otfnrarh 741 26 on on IN cord-345222-otfnrarh 741 27 the the DT cord-345222-otfnrarh 741 28 optimal optimal JJ cord-345222-otfnrarh 741 29 treatment treatment NN cord-345222-otfnrarh 741 30 of of IN cord-345222-otfnrarh 741 31 infection infection NN cord-345222-otfnrarh 741 32 ( ( -LRB- cord-345222-otfnrarh 741 33 bacterial bacterial JJ cord-345222-otfnrarh 741 34 , , , cord-345222-otfnrarh 741 35 fungal fungal JJ cord-345222-otfnrarh 741 36 and and CC cord-345222-otfnrarh 741 37 viral viral JJ cord-345222-otfnrarh 741 38 ) ) -RRB- cord-345222-otfnrarh 741 39 and and CC cord-345222-otfnrarh 741 40 the the DT cord-345222-otfnrarh 741 41 development development NN cord-345222-otfnrarh 741 42 and and CC cord-345222-otfnrarh 741 43 institution institution NN cord-345222-otfnrarh 741 44 of of IN cord-345222-otfnrarh 741 45 preventive preventive JJ cord-345222-otfnrarh 741 46 strategies strategy NNS cord-345222-otfnrarh 741 47 to to TO cord-345222-otfnrarh 741 48 minimize minimize VB cord-345222-otfnrarh 741 49 the the DT cord-345222-otfnrarh 741 50 development development NN cord-345222-otfnrarh 741 51 and and CC cord-345222-otfnrarh 741 52 spread spread NN cord-345222-otfnrarh 741 53 of of IN cord-345222-otfnrarh 741 54 resistance resistance NN cord-345222-otfnrarh 741 55 . . . cord-345222-otfnrarh 742 1 The the DT cord-345222-otfnrarh 742 2 journal journal NN cord-345222-otfnrarh 742 3 is be VBZ cord-345222-otfnrarh 742 4 specifically specifically RB cord-345222-otfnrarh 742 5 concerned concern VBN cord-345222-otfnrarh 742 6 with with IN cord-345222-otfnrarh 742 7 the the DT cord-345222-otfnrarh 742 8 epidemiology epidemiology NN cord-345222-otfnrarh 742 9 of of IN cord-345222-otfnrarh 742 10 antibiotic antibiotic JJ cord-345222-otfnrarh 742 11 resistance resistance NN cord-345222-otfnrarh 742 12 and and CC cord-345222-otfnrarh 742 13 the the DT cord-345222-otfnrarh 742 14 mechanisms mechanism NNS cord-345222-otfnrarh 742 15 of of IN cord-345222-otfnrarh 742 16 resistance resistance NN cord-345222-otfnrarh 742 17 development development NN cord-345222-otfnrarh 742 18 and and CC cord-345222-otfnrarh 742 19 diffusion diffusion NN cord-345222-otfnrarh 742 20 in in IN cord-345222-otfnrarh 742 21 both both DT cord-345222-otfnrarh 742 22 hospitals hospital NNS cord-345222-otfnrarh 742 23 and and CC cord-345222-otfnrarh 742 24 the the DT cord-345222-otfnrarh 742 25 community community NN cord-345222-otfnrarh 742 26 . . . cord-345222-otfnrarh 743 1 The the DT cord-345222-otfnrarh 743 2 manuscript manuscript NN cord-345222-otfnrarh 743 3 management management NN cord-345222-otfnrarh 743 4 system system NN cord-345222-otfnrarh 743 5 is be VBZ cord-345222-otfnrarh 743 6 completely completely RB cord-345222-otfnrarh 743 7 online online JJ cord-345222-otfnrarh 743 8 and and CC cord-345222-otfnrarh 743 9 includes include VBZ cord-345222-otfnrarh 743 10 a a DT cord-345222-otfnrarh 743 11 very very RB cord-345222-otfnrarh 743 12 quick quick JJ cord-345222-otfnrarh 743 13 and and CC cord-345222-otfnrarh 743 14 fair fair JJ cord-345222-otfnrarh 743 15 peerreview peerreview NN cord-345222-otfnrarh 743 16 system system NN cord-345222-otfnrarh 743 17 , , , cord-345222-otfnrarh 743 18 which which WDT cord-345222-otfnrarh 743 19 is be VBZ cord-345222-otfnrarh 743 20 all all RB cord-345222-otfnrarh 743 21 easy easy JJ cord-345222-otfnrarh 743 22 to to TO cord-345222-otfnrarh 743 23 use use VB cord-345222-otfnrarh 743 24 . . . cord-345222-otfnrarh 744 1 Visit visit VB cord-345222-otfnrarh 744 2 http://www.dovepress.com/ http://www.dovepress.com/ NN cord-345222-otfnrarh 744 3 testimonials.php testimonials.php NN cord-345222-otfnrarh 744 4 to to TO cord-345222-otfnrarh 744 5 read read VB cord-345222-otfnrarh 744 6 real real JJ cord-345222-otfnrarh 744 7 quotes quote NNS cord-345222-otfnrarh 744 8 from from IN cord-345222-otfnrarh 744 9 published publish VBN cord-345222-otfnrarh 744 10 authors author NNS cord-345222-otfnrarh 744 11 . . .