id	sid	tid	token	lemma	pos
cord-344093-3bniy5b5	1	1	key	key	JJ
cord-344093-3bniy5b5	1	2	:	:	:
cord-344093-3bniy5b5	1	3	cord-344093	cord-344093	NNP
cord-344093-3bniy5b5	1	4	-	-	HYPH
cord-344093-3bniy5b5	1	5	3bniy5b5	3bniy5b5	CD
cord-344093-3bniy5b5	1	6	authors	author	NNS
cord-344093-3bniy5b5	1	7	:	:	:
cord-344093-3bniy5b5	1	8	Peteranderl	Peteranderl	NNP
cord-344093-3bniy5b5	1	9	,	,	,
cord-344093-3bniy5b5	1	10	Christin	Christin	NNP
cord-344093-3bniy5b5	1	11	;	;	:
cord-344093-3bniy5b5	1	12	Herold	Herold	NNP
cord-344093-3bniy5b5	1	13	,	,	,
cord-344093-3bniy5b5	1	14	Susanne	Susanne	NNP
cord-344093-3bniy5b5	1	15	title	title	NN
cord-344093-3bniy5b5	1	16	:	:	:
cord-344093-3bniy5b5	2	1	The	the	DT
cord-344093-3bniy5b5	2	2	Impact	Impact	NNP
cord-344093-3bniy5b5	2	3	of	of	IN
cord-344093-3bniy5b5	2	4	the	the	DT
cord-344093-3bniy5b5	2	5	Interferon	Interferon	NNP
cord-344093-3bniy5b5	2	6	/	/	SYM
cord-344093-3bniy5b5	2	7	TNF	TNF	NNP
cord-344093-3bniy5b5	2	8	-	-	HYPH
cord-344093-3bniy5b5	2	9	Related	relate	VBN
cord-344093-3bniy5b5	2	10	Apoptosis	Apoptosis	NNP
cord-344093-3bniy5b5	2	11	-	-	HYPH
cord-344093-3bniy5b5	2	12	Inducing	induce	VBG
cord-344093-3bniy5b5	2	13	Ligand	Ligand	NNP
cord-344093-3bniy5b5	2	14	Signaling	Signaling	NNP
cord-344093-3bniy5b5	2	15	Axis	Axis	NNP
cord-344093-3bniy5b5	2	16	on	on	IN
cord-344093-3bniy5b5	2	17	Disease	Disease	NNP
cord-344093-3bniy5b5	2	18	Progression	Progression	NNP
cord-344093-3bniy5b5	2	19	in	in	IN
cord-344093-3bniy5b5	2	20	Respiratory	respiratory	JJ
cord-344093-3bniy5b5	2	21	Viral	viral	JJ
cord-344093-3bniy5b5	2	22	Infection	infection	NN
cord-344093-3bniy5b5	2	23	and	and	CC
cord-344093-3bniy5b5	2	24	Beyond	beyond	IN
cord-344093-3bniy5b5	2	25	date	date	NN
cord-344093-3bniy5b5	2	26	:	:	:
cord-344093-3bniy5b5	2	27	2017	2017	CD
cord-344093-3bniy5b5	2	28	-	-	HYPH
cord-344093-3bniy5b5	2	29	03	03	CD
cord-344093-3bniy5b5	2	30	-	-	HYPH
cord-344093-3bniy5b5	2	31	22	22	CD
cord-344093-3bniy5b5	2	32	journal	journal	NN
cord-344093-3bniy5b5	2	33	:	:	:
cord-344093-3bniy5b5	3	1	Front	Front	NNP
cord-344093-3bniy5b5	3	2	Immunol	Immunol	NNP
cord-344093-3bniy5b5	3	3	DOI	doi	NN
cord-344093-3bniy5b5	3	4	:	:	:
cord-344093-3bniy5b5	4	1	10.3389	10.3389	CD
cord-344093-3bniy5b5	4	2	/	/	SYM
cord-344093-3bniy5b5	4	3	fimmu.2017.00313	fimmu.2017.00313	NN
cord-344093-3bniy5b5	4	4	sha	sha	NNP
cord-344093-3bniy5b5	4	5	:	:	:
cord-344093-3bniy5b5	4	6	295d1050a0d5e811698a853c29cc8b388d4d92f7	295d1050a0d5e811698a853c29cc8b388d4d92f7	CD
cord-344093-3bniy5b5	4	7	doc_id	doc_id	CD
cord-344093-3bniy5b5	4	8	:	:	:
cord-344093-3bniy5b5	4	9	344093	344093	CD
cord-344093-3bniy5b5	4	10	cord_uid	cord_uid	NN
cord-344093-3bniy5b5	4	11	:	:	:
cord-344093-3bniy5b5	5	1	3bniy5b5	3bniy5b5	LS
cord-344093-3bniy5b5	5	2	Interferons	interferons	NN
cord-344093-3bniy5b5	5	3	(	(	-LRB-
cord-344093-3bniy5b5	5	4	IFNs	ifn	NNS
cord-344093-3bniy5b5	5	5	)	)	-RRB-
cord-344093-3bniy5b5	5	6	are	be	VBP
cord-344093-3bniy5b5	5	7	well	well	RB
cord-344093-3bniy5b5	5	8	described	describe	VBN
cord-344093-3bniy5b5	5	9	to	to	TO
cord-344093-3bniy5b5	5	10	be	be	VB
cord-344093-3bniy5b5	5	11	rapidly	rapidly	RB
cord-344093-3bniy5b5	5	12	induced	induce	VBN
cord-344093-3bniy5b5	5	13	upon	upon	IN
cord-344093-3bniy5b5	5	14	pathogen	pathogen	NN
cord-344093-3bniy5b5	5	15	-	-	HYPH
cord-344093-3bniy5b5	5	16	associated	associate	VBN
cord-344093-3bniy5b5	5	17	pattern	pattern	NN
cord-344093-3bniy5b5	5	18	recognition	recognition	NN
cord-344093-3bniy5b5	5	19	.	.	.
cord-344093-3bniy5b5	6	1	After	after	IN
cord-344093-3bniy5b5	6	2	binding	bind	VBG
cord-344093-3bniy5b5	6	3	to	to	IN
cord-344093-3bniy5b5	6	4	their	-PRON-	PRP$
cord-344093-3bniy5b5	6	5	respective	respective	JJ
cord-344093-3bniy5b5	6	6	IFN	IFN	NNP
cord-344093-3bniy5b5	6	7	receptors	receptor	NNS
cord-344093-3bniy5b5	6	8	and	and	CC
cord-344093-3bniy5b5	6	9	activation	activation	NN
cord-344093-3bniy5b5	6	10	of	of	IN
cord-344093-3bniy5b5	6	11	the	the	DT
cord-344093-3bniy5b5	6	12	cellular	cellular	JJ
cord-344093-3bniy5b5	6	13	JAK	JAK	NNP
cord-344093-3bniy5b5	6	14	/	/	SYM
cord-344093-3bniy5b5	6	15	signal	signal	NN
cord-344093-3bniy5b5	6	16	transducer	transducer	NN
cord-344093-3bniy5b5	6	17	and	and	CC
cord-344093-3bniy5b5	6	18	activator	activator	NN
cord-344093-3bniy5b5	6	19	of	of	IN
cord-344093-3bniy5b5	6	20	transcription	transcription	NN
cord-344093-3bniy5b5	6	21	signaling	signal	VBG
cord-344093-3bniy5b5	6	22	cascade	cascade	NN
cord-344093-3bniy5b5	6	23	,	,	,
cord-344093-3bniy5b5	6	24	they	-PRON-	PRP
cord-344093-3bniy5b5	6	25	stimulate	stimulate	VBP
cord-344093-3bniy5b5	6	26	the	the	DT
cord-344093-3bniy5b5	6	27	transcription	transcription	NN
cord-344093-3bniy5b5	6	28	of	of	IN
cord-344093-3bniy5b5	6	29	a	a	DT
cord-344093-3bniy5b5	6	30	plethora	plethora	NN
cord-344093-3bniy5b5	6	31	of	of	IN
cord-344093-3bniy5b5	6	32	IFN	IFN	NNP
cord-344093-3bniy5b5	6	33	-	-	HYPH
cord-344093-3bniy5b5	6	34	stimulated	stimulate	VBN
cord-344093-3bniy5b5	6	35	genes	gene	NNS
cord-344093-3bniy5b5	6	36	(	(	-LRB-
cord-344093-3bniy5b5	6	37	ISGs	ISGs	NNP
cord-344093-3bniy5b5	6	38	)	)	-RRB-
cord-344093-3bniy5b5	6	39	in	in	IN
cord-344093-3bniy5b5	6	40	infected	infect	VBN
cord-344093-3bniy5b5	6	41	as	as	RB
cord-344093-3bniy5b5	6	42	well	well	RB
cord-344093-3bniy5b5	6	43	as	as	IN
cord-344093-3bniy5b5	6	44	bystander	bystander	NN
cord-344093-3bniy5b5	6	45	cells	cell	NNS
cord-344093-3bniy5b5	6	46	such	such	JJ
cord-344093-3bniy5b5	6	47	as	as	IN
cord-344093-3bniy5b5	6	48	the	the	DT
cord-344093-3bniy5b5	6	49	non	non	JJ
cord-344093-3bniy5b5	6	50	-	-	JJ
cord-344093-3bniy5b5	6	51	infected	infected	JJ
cord-344093-3bniy5b5	6	52	epithelium	epithelium	NN
cord-344093-3bniy5b5	6	53	and	and	CC
cord-344093-3bniy5b5	6	54	cells	cell	NNS
cord-344093-3bniy5b5	6	55	of	of	IN
cord-344093-3bniy5b5	6	56	the	the	DT
cord-344093-3bniy5b5	6	57	immune	immune	JJ
cord-344093-3bniy5b5	6	58	system	system	NN
cord-344093-3bniy5b5	6	59	.	.	.
cord-344093-3bniy5b5	7	1	ISGs	ISGs	NNP
cord-344093-3bniy5b5	7	2	may	may	MD
cord-344093-3bniy5b5	7	3	directly	directly	RB
cord-344093-3bniy5b5	7	4	act	act	VB
cord-344093-3bniy5b5	7	5	on	on	IN
cord-344093-3bniy5b5	7	6	the	the	DT
cord-344093-3bniy5b5	7	7	invading	invade	VBG
cord-344093-3bniy5b5	7	8	pathogen	pathogen	NN
cord-344093-3bniy5b5	7	9	or	or	CC
cord-344093-3bniy5b5	7	10	can	can	MD
cord-344093-3bniy5b5	7	11	either	either	CC
cord-344093-3bniy5b5	7	12	positively	positively	RB
cord-344093-3bniy5b5	7	13	or	or	CC
cord-344093-3bniy5b5	7	14	negatively	negatively	RB
cord-344093-3bniy5b5	7	15	regulate	regulate	VB
cord-344093-3bniy5b5	7	16	the	the	DT
cord-344093-3bniy5b5	7	17	innate	innate	JJ
cord-344093-3bniy5b5	7	18	and	and	CC
cord-344093-3bniy5b5	7	19	adaptive	adaptive	JJ
cord-344093-3bniy5b5	7	20	immune	immune	JJ
cord-344093-3bniy5b5	7	21	response	response	NN
cord-344093-3bniy5b5	7	22	.	.	.
cord-344093-3bniy5b5	8	1	However	however	RB
cord-344093-3bniy5b5	8	2	,	,	,
cord-344093-3bniy5b5	8	3	IFNs	IFNs	NNP
cord-344093-3bniy5b5	8	4	and	and	CC
cord-344093-3bniy5b5	8	5	ISGs	isg	NNS
cord-344093-3bniy5b5	8	6	do	do	VBP
cord-344093-3bniy5b5	8	7	not	not	RB
cord-344093-3bniy5b5	8	8	only	only	RB
cord-344093-3bniy5b5	8	9	play	play	VB
cord-344093-3bniy5b5	8	10	a	a	DT
cord-344093-3bniy5b5	8	11	key	key	JJ
cord-344093-3bniy5b5	8	12	role	role	NN
cord-344093-3bniy5b5	8	13	in	in	IN
cord-344093-3bniy5b5	8	14	the	the	DT
cord-344093-3bniy5b5	8	15	limitation	limitation	NN
cord-344093-3bniy5b5	8	16	of	of	IN
cord-344093-3bniy5b5	8	17	pathogen	pathogen	NN
cord-344093-3bniy5b5	8	18	spread	spread	NN
cord-344093-3bniy5b5	8	19	but	but	CC
cord-344093-3bniy5b5	8	20	have	have	VBP
cord-344093-3bniy5b5	8	21	also	also	RB
cord-344093-3bniy5b5	8	22	been	be	VBN
cord-344093-3bniy5b5	8	23	recently	recently	RB
cord-344093-3bniy5b5	8	24	found	find	VBN
cord-344093-3bniy5b5	8	25	to	to	TO
cord-344093-3bniy5b5	8	26	provoke	provoke	VB
cord-344093-3bniy5b5	8	27	an	an	DT
cord-344093-3bniy5b5	8	28	unbalanced	unbalanced	JJ
cord-344093-3bniy5b5	8	29	,	,	,
cord-344093-3bniy5b5	8	30	overshooting	overshoot	VBG
cord-344093-3bniy5b5	8	31	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	8	32	response	response	NN
cord-344093-3bniy5b5	8	33	causing	cause	VBG
cord-344093-3bniy5b5	8	34	tissue	tissue	NN
cord-344093-3bniy5b5	8	35	injury	injury	NN
cord-344093-3bniy5b5	8	36	and	and	CC
cord-344093-3bniy5b5	8	37	hampering	hamper	VBG
cord-344093-3bniy5b5	8	38	repair	repair	NN
cord-344093-3bniy5b5	8	39	processes	process	NNS
cord-344093-3bniy5b5	8	40	.	.	.
cord-344093-3bniy5b5	9	1	A	a	DT
cord-344093-3bniy5b5	9	2	prominent	prominent	JJ
cord-344093-3bniy5b5	9	3	regulator	regulator	NN
cord-344093-3bniy5b5	9	4	of	of	IN
cord-344093-3bniy5b5	9	5	disease	disease	NN
cord-344093-3bniy5b5	9	6	outcome	outcome	NN
cord-344093-3bniy5b5	9	7	,	,	,
cord-344093-3bniy5b5	9	8	especially	especially	RB
cord-344093-3bniy5b5	9	9	in	in	IN
cord-344093-3bniy5b5	9	10	—	—	:
cord-344093-3bniy5b5	9	11	but	but	CC
cord-344093-3bniy5b5	9	12	not	not	RB
cord-344093-3bniy5b5	9	13	limited	limited	JJ
cord-344093-3bniy5b5	9	14	to	to	IN
cord-344093-3bniy5b5	9	15	—	—	:
cord-344093-3bniy5b5	9	16	respiratory	respiratory	JJ
cord-344093-3bniy5b5	9	17	viral	viral	JJ
cord-344093-3bniy5b5	9	18	infection	infection	NN
cord-344093-3bniy5b5	9	19	,	,	,
cord-344093-3bniy5b5	9	20	is	be	VBZ
cord-344093-3bniy5b5	9	21	the	the	DT
cord-344093-3bniy5b5	9	22	IFN	IFN	NNP
cord-344093-3bniy5b5	9	23	-	-	HYPH
cord-344093-3bniy5b5	9	24	dependent	dependent	JJ
cord-344093-3bniy5b5	9	25	mediator	mediator	NN
cord-344093-3bniy5b5	9	26	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	9	27	(	(	-LRB-
cord-344093-3bniy5b5	9	28	TNF	tnf	NN
cord-344093-3bniy5b5	9	29	-	-	HYPH
cord-344093-3bniy5b5	9	30	related	relate	VBN
cord-344093-3bniy5b5	9	31	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	9	32	-	-	HYPH
cord-344093-3bniy5b5	9	33	inducing	induce	VBG
cord-344093-3bniy5b5	9	34	ligand	ligand	NN
cord-344093-3bniy5b5	9	35	)	)	-RRB-
cord-344093-3bniy5b5	9	36	produced	produce	VBN
cord-344093-3bniy5b5	9	37	by	by	IN
cord-344093-3bniy5b5	9	38	several	several	JJ
cord-344093-3bniy5b5	9	39	cell	cell	NN
cord-344093-3bniy5b5	9	40	types	type	NNS
cord-344093-3bniy5b5	9	41	including	include	VBG
cord-344093-3bniy5b5	9	42	immune	immune	JJ
cord-344093-3bniy5b5	9	43	cells	cell	NNS
cord-344093-3bniy5b5	9	44	such	such	JJ
cord-344093-3bniy5b5	9	45	as	as	IN
cord-344093-3bniy5b5	9	46	macrophages	macrophage	NNS
cord-344093-3bniy5b5	9	47	or	or	CC
cord-344093-3bniy5b5	9	48	T	t	NN
cord-344093-3bniy5b5	9	49	cells	cell	NNS
cord-344093-3bniy5b5	9	50	.	.	.
cord-344093-3bniy5b5	10	1	First	first	RB
cord-344093-3bniy5b5	10	2	described	describe	VBN
cord-344093-3bniy5b5	10	3	as	as	IN
cord-344093-3bniy5b5	10	4	an	an	DT
cord-344093-3bniy5b5	10	5	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	10	6	-	-	HYPH
cord-344093-3bniy5b5	10	7	inducing	induce	VBG
cord-344093-3bniy5b5	10	8	agent	agent	NN
cord-344093-3bniy5b5	10	9	in	in	IN
cord-344093-3bniy5b5	10	10	transformed	transformed	JJ
cord-344093-3bniy5b5	10	11	cells	cell	NNS
cord-344093-3bniy5b5	10	12	,	,	,
cord-344093-3bniy5b5	10	13	it	-PRON-	PRP
cord-344093-3bniy5b5	10	14	is	be	VBZ
cord-344093-3bniy5b5	10	15	now	now	RB
cord-344093-3bniy5b5	10	16	also	also	RB
cord-344093-3bniy5b5	10	17	well	well	RB
cord-344093-3bniy5b5	10	18	established	establish	VBN
cord-344093-3bniy5b5	10	19	to	to	TO
cord-344093-3bniy5b5	10	20	rapidly	rapidly	RB
cord-344093-3bniy5b5	10	21	evoke	evoke	VB
cord-344093-3bniy5b5	10	22	cellular	cellular	JJ
cord-344093-3bniy5b5	10	23	stress	stress	NN
cord-344093-3bniy5b5	10	24	pathways	pathway	NNS
cord-344093-3bniy5b5	10	25	in	in	IN
cord-344093-3bniy5b5	10	26	epithelial	epithelial	JJ
cord-344093-3bniy5b5	10	27	cells	cell	NNS
cord-344093-3bniy5b5	10	28	,	,	,
cord-344093-3bniy5b5	10	29	finally	finally	RB
cord-344093-3bniy5b5	10	30	leading	lead	VBG
cord-344093-3bniy5b5	10	31	to	to	IN
cord-344093-3bniy5b5	10	32	caspase	caspase	NN
cord-344093-3bniy5b5	10	33	-	-	HYPH
cord-344093-3bniy5b5	10	34	dependent	dependent	JJ
cord-344093-3bniy5b5	10	35	or	or	CC
cord-344093-3bniy5b5	10	36	-independent	-independent	JJ
cord-344093-3bniy5b5	10	37	cell	cell	NN
cord-344093-3bniy5b5	10	38	death	death	NN
cord-344093-3bniy5b5	10	39	.	.	.
cord-344093-3bniy5b5	11	1	Hereby	hereby	RB
cord-344093-3bniy5b5	11	2	,	,	,
cord-344093-3bniy5b5	11	3	pathogen	pathogen	NN
cord-344093-3bniy5b5	11	4	spread	spread	NN
cord-344093-3bniy5b5	11	5	is	be	VBZ
cord-344093-3bniy5b5	11	6	limited	limit	VBN
cord-344093-3bniy5b5	11	7	;	;	:
cord-344093-3bniy5b5	11	8	however	however	RB
cord-344093-3bniy5b5	11	9	in	in	IN
cord-344093-3bniy5b5	11	10	some	some	DT
cord-344093-3bniy5b5	11	11	cases	case	NNS
cord-344093-3bniy5b5	11	12	,	,	,
cord-344093-3bniy5b5	11	13	also	also	RB
cord-344093-3bniy5b5	11	14	the	the	DT
cord-344093-3bniy5b5	11	15	surrounding	surround	VBG
cord-344093-3bniy5b5	11	16	tissue	tissue	NN
cord-344093-3bniy5b5	11	17	is	be	VBZ
cord-344093-3bniy5b5	11	18	severely	severely	RB
cord-344093-3bniy5b5	11	19	harmed	harm	VBN
cord-344093-3bniy5b5	11	20	,	,	,
cord-344093-3bniy5b5	11	21	thus	thus	RB
cord-344093-3bniy5b5	11	22	augmenting	augment	VBG
cord-344093-3bniy5b5	11	23	disease	disease	NN
cord-344093-3bniy5b5	11	24	severity	severity	NN
cord-344093-3bniy5b5	11	25	.	.	.
cord-344093-3bniy5b5	12	1	Interestingly	interestingly	RB
cord-344093-3bniy5b5	12	2	,	,	,
cord-344093-3bniy5b5	12	3	the	the	DT
cord-344093-3bniy5b5	12	4	lack	lack	NN
cord-344093-3bniy5b5	12	5	of	of	IN
cord-344093-3bniy5b5	12	6	a	a	DT
cord-344093-3bniy5b5	12	7	strictly	strictly	RB
cord-344093-3bniy5b5	12	8	controlled	control	VBN
cord-344093-3bniy5b5	12	9	and	and	CC
cord-344093-3bniy5b5	12	10	well	well	RB
cord-344093-3bniy5b5	12	11	balanced	balanced	JJ
cord-344093-3bniy5b5	12	12	IFN	IFN	NNP
cord-344093-3bniy5b5	12	13	/	/	SYM
cord-344093-3bniy5b5	12	14	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	12	15	signaling	signal	VBG
cord-344093-3bniy5b5	12	16	response	response	NN
cord-344093-3bniy5b5	12	17	has	have	VBZ
cord-344093-3bniy5b5	12	18	not	not	RB
cord-344093-3bniy5b5	12	19	only	only	RB
cord-344093-3bniy5b5	12	20	been	be	VBN
cord-344093-3bniy5b5	12	21	implicated	implicate	VBN
cord-344093-3bniy5b5	12	22	in	in	IN
cord-344093-3bniy5b5	12	23	viral	viral	JJ
cord-344093-3bniy5b5	12	24	infection	infection	NN
cord-344093-3bniy5b5	12	25	but	but	CC
cord-344093-3bniy5b5	12	26	might	may	MD
cord-344093-3bniy5b5	12	27	furthermore	furthermore	RB
cord-344093-3bniy5b5	12	28	be	be	VB
cord-344093-3bniy5b5	12	29	an	an	DT
cord-344093-3bniy5b5	12	30	important	important	JJ
cord-344093-3bniy5b5	12	31	determinant	determinant	NN
cord-344093-3bniy5b5	12	32	of	of	IN
cord-344093-3bniy5b5	12	33	disease	disease	NN
cord-344093-3bniy5b5	12	34	progression	progression	NN
cord-344093-3bniy5b5	12	35	in	in	IN
cord-344093-3bniy5b5	12	36	bacterial	bacterial	JJ
cord-344093-3bniy5b5	12	37	superinfections	superinfection	NNS
cord-344093-3bniy5b5	12	38	and	and	CC
cord-344093-3bniy5b5	12	39	in	in	IN
cord-344093-3bniy5b5	12	40	chronic	chronic	JJ
cord-344093-3bniy5b5	12	41	respiratory	respiratory	JJ
cord-344093-3bniy5b5	12	42	illness	illness	NN
cord-344093-3bniy5b5	12	43	.	.	.
cord-344093-3bniy5b5	13	1	Conclusively	conclusively	RB
cord-344093-3bniy5b5	13	2	,	,	,
cord-344093-3bniy5b5	13	3	the	the	DT
cord-344093-3bniy5b5	13	4	IFN	IFN	NNP
cord-344093-3bniy5b5	13	5	/	/	SYM
cord-344093-3bniy5b5	13	6	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	13	7	signaling	signal	VBG
cord-344093-3bniy5b5	13	8	axis	axis	NN
cord-344093-3bniy5b5	13	9	is	be	VBZ
cord-344093-3bniy5b5	13	10	subjected	subject	VBN
cord-344093-3bniy5b5	13	11	to	to	IN
cord-344093-3bniy5b5	13	12	a	a	DT
cord-344093-3bniy5b5	13	13	complex	complex	JJ
cord-344093-3bniy5b5	13	14	modulation	modulation	NN
cord-344093-3bniy5b5	13	15	and	and	CC
cord-344093-3bniy5b5	13	16	might	may	MD
cord-344093-3bniy5b5	13	17	be	be	VB
cord-344093-3bniy5b5	13	18	exploited	exploit	VBN
cord-344093-3bniy5b5	13	19	for	for	IN
cord-344093-3bniy5b5	13	20	the	the	DT
cord-344093-3bniy5b5	13	21	evaluation	evaluation	NN
cord-344093-3bniy5b5	13	22	of	of	IN
cord-344093-3bniy5b5	13	23	new	new	JJ
cord-344093-3bniy5b5	13	24	therapeutic	therapeutic	JJ
cord-344093-3bniy5b5	13	25	concepts	concept	NNS
cord-344093-3bniy5b5	13	26	aiming	aim	VBG
cord-344093-3bniy5b5	13	27	at	at	IN
cord-344093-3bniy5b5	13	28	attenuation	attenuation	NN
cord-344093-3bniy5b5	13	29	of	of	IN
cord-344093-3bniy5b5	13	30	tissue	tissue	NN
cord-344093-3bniy5b5	13	31	injury	injury	NN
cord-344093-3bniy5b5	13	32	.	.	.
cord-344093-3bniy5b5	14	1	Interferons	interferon	NNS
cord-344093-3bniy5b5	14	2	(	(	-LRB-
cord-344093-3bniy5b5	14	3	IFNs	ifn	NNS
cord-344093-3bniy5b5	14	4	)	)	-RRB-
cord-344093-3bniy5b5	14	5	are	be	VBP
cord-344093-3bniy5b5	14	6	well	well	RB
cord-344093-3bniy5b5	14	7	described	describe	VBN
cord-344093-3bniy5b5	14	8	to	to	TO
cord-344093-3bniy5b5	14	9	be	be	VB
cord-344093-3bniy5b5	14	10	rapidly	rapidly	RB
cord-344093-3bniy5b5	14	11	induced	induce	VBN
cord-344093-3bniy5b5	14	12	upon	upon	IN
cord-344093-3bniy5b5	14	13	pathogen	pathogen	NN
cord-344093-3bniy5b5	14	14	-	-	HYPH
cord-344093-3bniy5b5	14	15	associated	associate	VBN
cord-344093-3bniy5b5	14	16	pattern	pattern	NN
cord-344093-3bniy5b5	14	17	recognition	recognition	NN
cord-344093-3bniy5b5	14	18	.	.	.
cord-344093-3bniy5b5	15	1	After	after	IN
cord-344093-3bniy5b5	15	2	binding	bind	VBG
cord-344093-3bniy5b5	15	3	to	to	IN
cord-344093-3bniy5b5	15	4	their	-PRON-	PRP$
cord-344093-3bniy5b5	15	5	respective	respective	JJ
cord-344093-3bniy5b5	15	6	IFN	IFN	NNP
cord-344093-3bniy5b5	15	7	receptors	receptor	NNS
cord-344093-3bniy5b5	15	8	and	and	CC
cord-344093-3bniy5b5	15	9	activation	activation	NN
cord-344093-3bniy5b5	15	10	of	of	IN
cord-344093-3bniy5b5	15	11	the	the	DT
cord-344093-3bniy5b5	15	12	cellular	cellular	JJ
cord-344093-3bniy5b5	15	13	JAK	JAK	NNP
cord-344093-3bniy5b5	15	14	/	/	SYM
cord-344093-3bniy5b5	15	15	signal	signal	NN
cord-344093-3bniy5b5	15	16	transducer	transducer	NN
cord-344093-3bniy5b5	15	17	and	and	CC
cord-344093-3bniy5b5	15	18	activator	activator	NN
cord-344093-3bniy5b5	15	19	of	of	IN
cord-344093-3bniy5b5	15	20	transcription	transcription	NN
cord-344093-3bniy5b5	15	21	signaling	signal	VBG
cord-344093-3bniy5b5	15	22	cascade	cascade	NN
cord-344093-3bniy5b5	15	23	,	,	,
cord-344093-3bniy5b5	15	24	they	-PRON-	PRP
cord-344093-3bniy5b5	15	25	stimulate	stimulate	VBP
cord-344093-3bniy5b5	15	26	the	the	DT
cord-344093-3bniy5b5	15	27	transcription	transcription	NN
cord-344093-3bniy5b5	15	28	of	of	IN
cord-344093-3bniy5b5	15	29	a	a	DT
cord-344093-3bniy5b5	15	30	plethora	plethora	NN
cord-344093-3bniy5b5	15	31	of	of	IN
cord-344093-3bniy5b5	15	32	IFN	IFN	NNP
cord-344093-3bniy5b5	15	33	-	-	HYPH
cord-344093-3bniy5b5	15	34	stimulated	stimulate	VBN
cord-344093-3bniy5b5	15	35	genes	gene	NNS
cord-344093-3bniy5b5	15	36	(	(	-LRB-
cord-344093-3bniy5b5	15	37	ISGs	ISGs	NNP
cord-344093-3bniy5b5	15	38	)	)	-RRB-
cord-344093-3bniy5b5	15	39	in	in	IN
cord-344093-3bniy5b5	15	40	infected	infect	VBN
cord-344093-3bniy5b5	15	41	as	as	RB
cord-344093-3bniy5b5	15	42	well	well	RB
cord-344093-3bniy5b5	15	43	as	as	IN
cord-344093-3bniy5b5	15	44	bystander	bystander	NN
cord-344093-3bniy5b5	15	45	cells	cell	NNS
cord-344093-3bniy5b5	15	46	such	such	JJ
cord-344093-3bniy5b5	15	47	as	as	IN
cord-344093-3bniy5b5	15	48	the	the	DT
cord-344093-3bniy5b5	15	49	non	non	JJ
cord-344093-3bniy5b5	15	50	-	-	JJ
cord-344093-3bniy5b5	15	51	infected	infected	JJ
cord-344093-3bniy5b5	15	52	epithelium	epithelium	NN
cord-344093-3bniy5b5	15	53	and	and	CC
cord-344093-3bniy5b5	15	54	cells	cell	NNS
cord-344093-3bniy5b5	15	55	of	of	IN
cord-344093-3bniy5b5	15	56	the	the	DT
cord-344093-3bniy5b5	15	57	immune	immune	JJ
cord-344093-3bniy5b5	15	58	system	system	NN
cord-344093-3bniy5b5	15	59	.	.	.
cord-344093-3bniy5b5	16	1	ISGs	ISGs	NNP
cord-344093-3bniy5b5	16	2	may	may	MD
cord-344093-3bniy5b5	16	3	directly	directly	RB
cord-344093-3bniy5b5	16	4	act	act	VB
cord-344093-3bniy5b5	16	5	on	on	IN
cord-344093-3bniy5b5	16	6	the	the	DT
cord-344093-3bniy5b5	16	7	invading	invade	VBG
cord-344093-3bniy5b5	16	8	pathogen	pathogen	NN
cord-344093-3bniy5b5	16	9	or	or	CC
cord-344093-3bniy5b5	16	10	can	can	MD
cord-344093-3bniy5b5	16	11	either	either	CC
cord-344093-3bniy5b5	16	12	positively	positively	RB
cord-344093-3bniy5b5	16	13	or	or	CC
cord-344093-3bniy5b5	16	14	negatively	negatively	RB
cord-344093-3bniy5b5	16	15	regulate	regulate	VB
cord-344093-3bniy5b5	16	16	the	the	DT
cord-344093-3bniy5b5	16	17	innate	innate	JJ
cord-344093-3bniy5b5	16	18	and	and	CC
cord-344093-3bniy5b5	16	19	adaptive	adaptive	JJ
cord-344093-3bniy5b5	16	20	immune	immune	JJ
cord-344093-3bniy5b5	16	21	response	response	NN
cord-344093-3bniy5b5	16	22	.	.	.
cord-344093-3bniy5b5	17	1	However	however	RB
cord-344093-3bniy5b5	17	2	,	,	,
cord-344093-3bniy5b5	17	3	IFNs	IFNs	NNP
cord-344093-3bniy5b5	17	4	and	and	CC
cord-344093-3bniy5b5	17	5	ISGs	isg	NNS
cord-344093-3bniy5b5	17	6	do	do	VBP
cord-344093-3bniy5b5	17	7	not	not	RB
cord-344093-3bniy5b5	17	8	only	only	RB
cord-344093-3bniy5b5	17	9	play	play	VB
cord-344093-3bniy5b5	17	10	a	a	DT
cord-344093-3bniy5b5	17	11	key	key	JJ
cord-344093-3bniy5b5	17	12	role	role	NN
cord-344093-3bniy5b5	17	13	in	in	IN
cord-344093-3bniy5b5	17	14	the	the	DT
cord-344093-3bniy5b5	17	15	limitation	limitation	NN
cord-344093-3bniy5b5	17	16	of	of	IN
cord-344093-3bniy5b5	17	17	pathogen	pathogen	NN
cord-344093-3bniy5b5	17	18	spread	spread	NN
cord-344093-3bniy5b5	17	19	but	but	CC
cord-344093-3bniy5b5	17	20	have	have	VBP
cord-344093-3bniy5b5	17	21	also	also	RB
cord-344093-3bniy5b5	17	22	been	be	VBN
cord-344093-3bniy5b5	17	23	recently	recently	RB
cord-344093-3bniy5b5	17	24	found	find	VBN
cord-344093-3bniy5b5	17	25	to	to	TO
cord-344093-3bniy5b5	17	26	provoke	provoke	VB
cord-344093-3bniy5b5	17	27	an	an	DT
cord-344093-3bniy5b5	17	28	unbalanced	unbalanced	JJ
cord-344093-3bniy5b5	17	29	,	,	,
cord-344093-3bniy5b5	17	30	overshooting	overshoot	VBG
cord-344093-3bniy5b5	17	31	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	17	32	response	response	NN
cord-344093-3bniy5b5	17	33	causing	cause	VBG
cord-344093-3bniy5b5	17	34	tissue	tissue	NN
cord-344093-3bniy5b5	17	35	injury	injury	NN
cord-344093-3bniy5b5	17	36	and	and	CC
cord-344093-3bniy5b5	17	37	hampering	hamper	VBG
cord-344093-3bniy5b5	17	38	repair	repair	NN
cord-344093-3bniy5b5	17	39	processes	process	NNS
cord-344093-3bniy5b5	17	40	.	.	.
cord-344093-3bniy5b5	18	1	A	a	DT
cord-344093-3bniy5b5	18	2	prominent	prominent	JJ
cord-344093-3bniy5b5	18	3	regulator	regulator	NN
cord-344093-3bniy5b5	18	4	of	of	IN
cord-344093-3bniy5b5	18	5	disease	disease	NN
cord-344093-3bniy5b5	18	6	outcome	outcome	NN
cord-344093-3bniy5b5	18	7	,	,	,
cord-344093-3bniy5b5	18	8	especially	especially	RB
cord-344093-3bniy5b5	18	9	in	in	IN
cord-344093-3bniy5b5	18	10	-	-	:
cord-344093-3bniy5b5	18	11	but	but	CC
cord-344093-3bniy5b5	18	12	not	not	RB
cord-344093-3bniy5b5	18	13	limited	limit	VBN
cord-344093-3bniy5b5	18	14	to	to	IN
cord-344093-3bniy5b5	18	15	-	-	HYPH
cord-344093-3bniy5b5	18	16	respiratory	respiratory	JJ
cord-344093-3bniy5b5	18	17	viral	viral	JJ
cord-344093-3bniy5b5	18	18	infection	infection	NN
cord-344093-3bniy5b5	18	19	,	,	,
cord-344093-3bniy5b5	18	20	is	be	VBZ
cord-344093-3bniy5b5	18	21	the	the	DT
cord-344093-3bniy5b5	18	22	IFN	IFN	NNP
cord-344093-3bniy5b5	18	23	-	-	HYPH
cord-344093-3bniy5b5	18	24	dependent	dependent	JJ
cord-344093-3bniy5b5	18	25	mediator	mediator	NN
cord-344093-3bniy5b5	18	26	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	18	27	(	(	-LRB-
cord-344093-3bniy5b5	18	28	TNF	tnf	NN
cord-344093-3bniy5b5	18	29	-	-	HYPH
cord-344093-3bniy5b5	18	30	related	relate	VBN
cord-344093-3bniy5b5	18	31	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	18	32	-	-	HYPH
cord-344093-3bniy5b5	18	33	inducing	induce	VBG
cord-344093-3bniy5b5	18	34	ligand	ligand	NN
cord-344093-3bniy5b5	18	35	)	)	-RRB-
cord-344093-3bniy5b5	18	36	produced	produce	VBN
cord-344093-3bniy5b5	18	37	by	by	IN
cord-344093-3bniy5b5	18	38	several	several	JJ
cord-344093-3bniy5b5	18	39	cell	cell	NN
cord-344093-3bniy5b5	18	40	types	type	NNS
cord-344093-3bniy5b5	18	41	including	include	VBG
cord-344093-3bniy5b5	18	42	immune	immune	JJ
cord-344093-3bniy5b5	18	43	cells	cell	NNS
cord-344093-3bniy5b5	18	44	such	such	JJ
cord-344093-3bniy5b5	18	45	as	as	IN
cord-344093-3bniy5b5	18	46	macrophages	macrophage	NNS
cord-344093-3bniy5b5	18	47	or	or	CC
cord-344093-3bniy5b5	18	48	T	t	NN
cord-344093-3bniy5b5	18	49	cells	cell	NNS
cord-344093-3bniy5b5	18	50	.	.	.
cord-344093-3bniy5b5	19	1	First	first	RB
cord-344093-3bniy5b5	19	2	described	describe	VBN
cord-344093-3bniy5b5	19	3	as	as	IN
cord-344093-3bniy5b5	19	4	an	an	DT
cord-344093-3bniy5b5	19	5	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	19	6	-	-	HYPH
cord-344093-3bniy5b5	19	7	inducing	induce	VBG
cord-344093-3bniy5b5	19	8	agent	agent	NN
cord-344093-3bniy5b5	19	9	in	in	IN
cord-344093-3bniy5b5	19	10	transformed	transformed	JJ
cord-344093-3bniy5b5	19	11	cells	cell	NNS
cord-344093-3bniy5b5	19	12	,	,	,
cord-344093-3bniy5b5	19	13	it	-PRON-	PRP
cord-344093-3bniy5b5	19	14	is	be	VBZ
cord-344093-3bniy5b5	19	15	now	now	RB
cord-344093-3bniy5b5	19	16	also	also	RB
cord-344093-3bniy5b5	19	17	well	well	RB
cord-344093-3bniy5b5	19	18	established	establish	VBN
cord-344093-3bniy5b5	19	19	to	to	TO
cord-344093-3bniy5b5	19	20	rapidly	rapidly	RB
cord-344093-3bniy5b5	19	21	evoke	evoke	VB
cord-344093-3bniy5b5	19	22	cellular	cellular	JJ
cord-344093-3bniy5b5	19	23	stress	stress	NN
cord-344093-3bniy5b5	19	24	pathways	pathway	NNS
cord-344093-3bniy5b5	19	25	in	in	IN
cord-344093-3bniy5b5	19	26	epithelial	epithelial	JJ
cord-344093-3bniy5b5	19	27	cells	cell	NNS
cord-344093-3bniy5b5	19	28	,	,	,
cord-344093-3bniy5b5	19	29	finally	finally	RB
cord-344093-3bniy5b5	19	30	leading	lead	VBG
cord-344093-3bniy5b5	19	31	to	to	IN
cord-344093-3bniy5b5	19	32	caspase	caspase	NN
cord-344093-3bniy5b5	19	33	-	-	HYPH
cord-344093-3bniy5b5	19	34	dependent	dependent	JJ
cord-344093-3bniy5b5	19	35	or	or	CC
cord-344093-3bniy5b5	19	36	-independent	-independent	JJ
cord-344093-3bniy5b5	19	37	cell	cell	NN
cord-344093-3bniy5b5	19	38	death	death	NN
cord-344093-3bniy5b5	19	39	.	.	.
cord-344093-3bniy5b5	20	1	Hereby	hereby	RB
cord-344093-3bniy5b5	20	2	,	,	,
cord-344093-3bniy5b5	20	3	pathogen	pathogen	NN
cord-344093-3bniy5b5	20	4	spread	spread	NN
cord-344093-3bniy5b5	20	5	is	be	VBZ
cord-344093-3bniy5b5	20	6	limited	limit	VBN
cord-344093-3bniy5b5	20	7	;	;	:
cord-344093-3bniy5b5	20	8	however	however	RB
cord-344093-3bniy5b5	20	9	in	in	IN
cord-344093-3bniy5b5	20	10	some	some	DT
cord-344093-3bniy5b5	20	11	cases	case	NNS
cord-344093-3bniy5b5	20	12	,	,	,
cord-344093-3bniy5b5	20	13	also	also	RB
cord-344093-3bniy5b5	20	14	the	the	DT
cord-344093-3bniy5b5	20	15	surrounding	surround	VBG
cord-344093-3bniy5b5	20	16	tissue	tissue	NN
cord-344093-3bniy5b5	20	17	is	be	VBZ
cord-344093-3bniy5b5	20	18	severely	severely	RB
cord-344093-3bniy5b5	20	19	harmed	harm	VBN
cord-344093-3bniy5b5	20	20	,	,	,
cord-344093-3bniy5b5	20	21	thus	thus	RB
cord-344093-3bniy5b5	20	22	augmenting	augment	VBG
cord-344093-3bniy5b5	20	23	disease	disease	NN
cord-344093-3bniy5b5	20	24	severity	severity	NN
cord-344093-3bniy5b5	20	25	.	.	.
cord-344093-3bniy5b5	21	1	Interestingly	interestingly	RB
cord-344093-3bniy5b5	21	2	,	,	,
cord-344093-3bniy5b5	21	3	the	the	DT
cord-344093-3bniy5b5	21	4	lack	lack	NN
cord-344093-3bniy5b5	21	5	of	of	IN
cord-344093-3bniy5b5	21	6	a	a	DT
cord-344093-3bniy5b5	21	7	strictly	strictly	RB
cord-344093-3bniy5b5	21	8	controlled	control	VBN
cord-344093-3bniy5b5	21	9	and	and	CC
cord-344093-3bniy5b5	21	10	well	well	RB
cord-344093-3bniy5b5	21	11	balanced	balanced	JJ
cord-344093-3bniy5b5	21	12	IFN	IFN	NNP
cord-344093-3bniy5b5	21	13	/	/	SYM
cord-344093-3bniy5b5	21	14	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	21	15	signaling	signal	VBG
cord-344093-3bniy5b5	21	16	response	response	NN
cord-344093-3bniy5b5	21	17	has	have	VBZ
cord-344093-3bniy5b5	21	18	not	not	RB
cord-344093-3bniy5b5	21	19	only	only	RB
cord-344093-3bniy5b5	21	20	been	be	VBN
cord-344093-3bniy5b5	21	21	implicated	implicate	VBN
cord-344093-3bniy5b5	21	22	in	in	IN
cord-344093-3bniy5b5	21	23	viral	viral	JJ
cord-344093-3bniy5b5	21	24	infection	infection	NN
cord-344093-3bniy5b5	21	25	but	but	CC
cord-344093-3bniy5b5	21	26	might	may	MD
cord-344093-3bniy5b5	21	27	furthermore	furthermore	RB
cord-344093-3bniy5b5	21	28	be	be	VB
cord-344093-3bniy5b5	21	29	an	an	DT
cord-344093-3bniy5b5	21	30	important	important	JJ
cord-344093-3bniy5b5	21	31	determinant	determinant	NN
cord-344093-3bniy5b5	21	32	of	of	IN
cord-344093-3bniy5b5	21	33	disease	disease	NN
cord-344093-3bniy5b5	21	34	progression	progression	NN
cord-344093-3bniy5b5	21	35	in	in	IN
cord-344093-3bniy5b5	21	36	bacterial	bacterial	JJ
cord-344093-3bniy5b5	21	37	superinfections	superinfection	NNS
cord-344093-3bniy5b5	21	38	and	and	CC
cord-344093-3bniy5b5	21	39	in	in	IN
cord-344093-3bniy5b5	21	40	chronic	chronic	JJ
cord-344093-3bniy5b5	21	41	respiratory	respiratory	JJ
cord-344093-3bniy5b5	21	42	illness	illness	NN
cord-344093-3bniy5b5	21	43	.	.	.
cord-344093-3bniy5b5	22	1	Conclusively	conclusively	RB
cord-344093-3bniy5b5	22	2	,	,	,
cord-344093-3bniy5b5	22	3	the	the	DT
cord-344093-3bniy5b5	22	4	IFN/	IFN/	NNP
cord-344093-3bniy5b5	22	5	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	22	6	signaling	signal	VBG
cord-344093-3bniy5b5	22	7	axis	axis	NN
cord-344093-3bniy5b5	22	8	is	be	VBZ
cord-344093-3bniy5b5	22	9	subjected	subject	VBN
cord-344093-3bniy5b5	22	10	to	to	IN
cord-344093-3bniy5b5	22	11	a	a	DT
cord-344093-3bniy5b5	22	12	complex	complex	JJ
cord-344093-3bniy5b5	22	13	modulation	modulation	NN
cord-344093-3bniy5b5	22	14	and	and	CC
cord-344093-3bniy5b5	22	15	might	may	MD
cord-344093-3bniy5b5	22	16	be	be	VB
cord-344093-3bniy5b5	22	17	exploited	exploit	VBN
cord-344093-3bniy5b5	22	18	for	for	IN
cord-344093-3bniy5b5	22	19	the	the	DT
cord-344093-3bniy5b5	22	20	evaluation	evaluation	NN
cord-344093-3bniy5b5	22	21	of	of	IN
cord-344093-3bniy5b5	22	22	new	new	JJ
cord-344093-3bniy5b5	22	23	therapeutic	therapeutic	JJ
cord-344093-3bniy5b5	22	24	concepts	concept	NNS
cord-344093-3bniy5b5	22	25	aiming	aim	VBG
cord-344093-3bniy5b5	22	26	at	at	IN
cord-344093-3bniy5b5	22	27	attenuation	attenuation	NN
cord-344093-3bniy5b5	22	28	of	of	IN
cord-344093-3bniy5b5	22	29	tissue	tissue	NN
cord-344093-3bniy5b5	22	30	injury	injury	NN
cord-344093-3bniy5b5	22	31	.	.	.
cord-344093-3bniy5b5	23	1	(	(	-LRB-
cord-344093-3bniy5b5	23	2	73	73	CD
cord-344093-3bniy5b5	23	3	)	)	-RRB-
cord-344093-3bniy5b5	23	4	Cell	cell	NN
cord-344093-3bniy5b5	23	5	death	death	NN
cord-344093-3bniy5b5	23	6	induction	induction	NN
cord-344093-3bniy5b5	23	7	,	,	,
cord-344093-3bniy5b5	23	8	e.g.	e.g.	RB
cord-344093-3bniy5b5	23	9	,	,	,
cord-344093-3bniy5b5	23	10	Bcl-2-associated	Bcl-2-associated	NNP
cord-344093-3bniy5b5	23	11	X	X	NNP
cord-344093-3bniy5b5	23	12	protein	protein	NN
cord-344093-3bniy5b5	23	13	,	,	,
cord-344093-3bniy5b5	23	14	caspase-8	caspase-8	NNP
cord-344093-3bniy5b5	23	15	,	,	,
cord-344093-3bniy5b5	23	16	Fas	Fas	NNP
cord-344093-3bniy5b5	23	17	-	-	HYPH
cord-344093-3bniy5b5	23	18	associated	associate	VBN
cord-344093-3bniy5b5	23	19	protein	protein	NN
cord-344093-3bniy5b5	23	20	with	with	IN
cord-344093-3bniy5b5	23	21	death	death	NN
cord-344093-3bniy5b5	23	22	domain	domain	NN
cord-344093-3bniy5b5	23	23	,	,	,
cord-344093-3bniy5b5	23	24	Fas	Fas	NNP
cord-344093-3bniy5b5	23	25	ligand	ligand	NN
cord-344093-3bniy5b5	23	26	,	,	,
cord-344093-3bniy5b5	23	27	and	and	CC
cord-344093-3bniy5b5	23	28	TNF	tnf	NN
cord-344093-3bniy5b5	23	29	-	-	HYPH
cord-344093-3bniy5b5	23	30	related	relate	VBN
cord-344093-3bniy5b5	23	31	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	23	32	-	-	HYPH
cord-344093-3bniy5b5	23	33	inducing	induce	VBG
cord-344093-3bniy5b5	23	34	ligand	ligand	NN
cord-344093-3bniy5b5	24	1	(	(	-LRB-
cord-344093-3bniy5b5	24	2	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	24	3	)	)	-RRB-
cord-344093-3bniy5b5	24	4	dsRNA	dsRNA	.
cord-344093-3bniy5b5	25	1	,	,	,
cord-344093-3bniy5b5	25	2	polyI	polyI	NNP
cord-344093-3bniy5b5	25	3	:	:	:
cord-344093-3bniy5b5	25	4	C	C	NNP
cord-344093-3bniy5b5	25	5	(	(	-LRB-
cord-344093-3bniy5b5	25	6	4	4	CD
cord-344093-3bniy5b5	25	7	,	,	,
cord-344093-3bniy5b5	25	8	110	110	CD
cord-344093-3bniy5b5	25	9	)	)	-RRB-
cord-344093-3bniy5b5	25	10	IAV	IAV	NNP
cord-344093-3bniy5b5	25	11	(	(	-LRB-
cord-344093-3bniy5b5	25	12	4	4	CD
cord-344093-3bniy5b5	25	13	,	,	,
cord-344093-3bniy5b5	25	14	5	5	CD
cord-344093-3bniy5b5	25	15	,	,	,
cord-344093-3bniy5b5	25	16	10	10	CD
cord-344093-3bniy5b5	25	17	,	,	,
cord-344093-3bniy5b5	25	18	115	115	CD
cord-344093-3bniy5b5	25	19	)	)	-RRB-
cord-344093-3bniy5b5	26	1	Sendai	Sendai	NNP
cord-344093-3bniy5b5	26	2	virus	virus	NN
cord-344093-3bniy5b5	26	3	(	(	-LRB-
cord-344093-3bniy5b5	26	4	110	110	CD
cord-344093-3bniy5b5	26	5	)	)	-RRB-
cord-344093-3bniy5b5	27	1	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	27	2	Virus	Virus	NNP
cord-344093-3bniy5b5	27	3	control	control	NN
cord-344093-3bniy5b5	27	4	by	by	IN
cord-344093-3bniy5b5	27	5	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	27	6	induction	induction	NN
cord-344093-3bniy5b5	27	7	in	in	IN
cord-344093-3bniy5b5	27	8	infected	infected	JJ
cord-344093-3bniy5b5	27	9	cells	cell	NNS
cord-344093-3bniy5b5	27	10	IAV	IAV	NNP
cord-344093-3bniy5b5	27	11	(	(	-LRB-
cord-344093-3bniy5b5	27	12	6	6	CD
cord-344093-3bniy5b5	27	13	,	,	,
cord-344093-3bniy5b5	27	14	170	170	CD
cord-344093-3bniy5b5	27	15	,	,	,
cord-344093-3bniy5b5	27	16	171	171	CD
cord-344093-3bniy5b5	27	17	)	)	-RRB-
cord-344093-3bniy5b5	28	1	Tissue	tissue	NN
cord-344093-3bniy5b5	28	2	injury	injury	NN
cord-344093-3bniy5b5	28	3	by	by	IN
cord-344093-3bniy5b5	28	4	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	28	5	of	of	IN
cord-344093-3bniy5b5	28	6	both	both	CC
cord-344093-3bniy5b5	28	7	infected	infected	JJ
cord-344093-3bniy5b5	28	8	and	and	CC
cord-344093-3bniy5b5	28	9	non	non	JJ
cord-344093-3bniy5b5	28	10	-	-	JJ
cord-344093-3bniy5b5	28	11	infected	infected	JJ
cord-344093-3bniy5b5	28	12	alveolar	alveolar	NN
cord-344093-3bniy5b5	28	13	epithelial	epithelial	JJ
cord-344093-3bniy5b5	28	14	cells	cell	NNS
cord-344093-3bniy5b5	28	15	,	,	,
cord-344093-3bniy5b5	28	16	lung	lung	NN
cord-344093-3bniy5b5	28	17	macrophages	macrophage	NNS
cord-344093-3bniy5b5	28	18	IAV	IAV	NNP
cord-344093-3bniy5b5	28	19	(	(	-LRB-
cord-344093-3bniy5b5	28	20	5	5	CD
cord-344093-3bniy5b5	28	21	,	,	,
cord-344093-3bniy5b5	28	22	7	7	CD
cord-344093-3bniy5b5	28	23	,	,	,
cord-344093-3bniy5b5	28	24	10	10	CD
cord-344093-3bniy5b5	28	25	)	)	-RRB-
cord-344093-3bniy5b5	28	26	RSV	RSV	NNP
cord-344093-3bniy5b5	28	27	(	(	-LRB-
cord-344093-3bniy5b5	28	28	137	137	CD
cord-344093-3bniy5b5	28	29	)	)	-RRB-
cord-344093-3bniy5b5	28	30	Necrosis	necrosis	NN
cord-344093-3bniy5b5	28	31	of	of	IN
cord-344093-3bniy5b5	28	32	fibroblasts	fibroblast	NNS
cord-344093-3bniy5b5	28	33	,	,	,
cord-344093-3bniy5b5	28	34	dendritic	dendritic	JJ
cord-344093-3bniy5b5	28	35	cells	cell	NNS
cord-344093-3bniy5b5	28	36	,	,	,
cord-344093-3bniy5b5	28	37	and	and	CC
cord-344093-3bniy5b5	28	38	epithelial	epithelial	JJ
cord-344093-3bniy5b5	28	39	cells	cell	NNS
cord-344093-3bniy5b5	29	1	IAV	IAV	NNP
cord-344093-3bniy5b5	29	2	(	(	-LRB-
cord-344093-3bniy5b5	29	3	146	146	CD
cord-344093-3bniy5b5	29	4	,	,	,
cord-344093-3bniy5b5	29	5	147	147	CD
cord-344093-3bniy5b5	29	6	,	,	,
cord-344093-3bniy5b5	29	7	168	168	CD
cord-344093-3bniy5b5	29	8	)	)	-RRB-
cord-344093-3bniy5b5	29	9	Increased	increase	VBN
cord-344093-3bniy5b5	29	10	cellular	cellular	JJ
cord-344093-3bniy5b5	29	11	infiltration	infiltration	NN
cord-344093-3bniy5b5	29	12	CoV	cov	NN
cord-344093-3bniy5b5	29	13	(	(	-LRB-
cord-344093-3bniy5b5	29	14	175	175	CD
cord-344093-3bniy5b5	29	15	)	)	-RRB-
cord-344093-3bniy5b5	30	1	Decreased	decrease	VBN
cord-344093-3bniy5b5	30	2	expression	expression	NN
cord-344093-3bniy5b5	30	3	of	of	IN
cord-344093-3bniy5b5	30	4	Na	Na	NNP
cord-344093-3bniy5b5	30	5	,	,	,
cord-344093-3bniy5b5	30	6	K	K	NNP
cord-344093-3bniy5b5	30	7	-	-	HYPH
cord-344093-3bniy5b5	30	8	ATPase	ATPase	NNP
cord-344093-3bniy5b5	30	9	,	,	,
cord-344093-3bniy5b5	30	10	impaired	impaired	JJ
cord-344093-3bniy5b5	30	11	epithelial	epithelial	JJ
cord-344093-3bniy5b5	30	12	fluid	fluid	JJ
cord-344093-3bniy5b5	30	13	reabsorption	reabsorption	NN
cord-344093-3bniy5b5	30	14	IAV	IAV	NNP
cord-344093-3bniy5b5	30	15	(	(	-LRB-
cord-344093-3bniy5b5	30	16	11	11	CD
cord-344093-3bniy5b5	30	17	)	)	-RRB-
cord-344093-3bniy5b5	31	1	iNTRODUCTiON	iNTRODUCTiON	NNP
cord-344093-3bniy5b5	32	1	In	in	IN
cord-344093-3bniy5b5	32	2	1957	1957	CD
cord-344093-3bniy5b5	32	3	,	,	,
cord-344093-3bniy5b5	32	4	Isaacs	Isaacs	NNP
cord-344093-3bniy5b5	32	5	and	and	CC
cord-344093-3bniy5b5	32	6	Lindenmann	Lindenmann	NNP
cord-344093-3bniy5b5	32	7	(	(	-LRB-
cord-344093-3bniy5b5	32	8	1	1	CD
cord-344093-3bniy5b5	32	9	)	)	-RRB-
cord-344093-3bniy5b5	32	10	first	first	RB
cord-344093-3bniy5b5	32	11	recognized	recognize	VBD
cord-344093-3bniy5b5	32	12	the	the	DT
cord-344093-3bniy5b5	32	13	potential	potential	NN
cord-344093-3bniy5b5	32	14	of	of	IN
cord-344093-3bniy5b5	32	15	a	a	DT
cord-344093-3bniy5b5	32	16	soluble	soluble	JJ
cord-344093-3bniy5b5	32	17	and	and	CC
cord-344093-3bniy5b5	32	18	probably	probably	RB
cord-344093-3bniy5b5	32	19	cell	cell	NN
cord-344093-3bniy5b5	32	20	-	-	HYPH
cord-344093-3bniy5b5	32	21	derived	derive	VBN
cord-344093-3bniy5b5	32	22	factor	factor	NN
cord-344093-3bniy5b5	32	23	to	to	TO
cord-344093-3bniy5b5	32	24	combat	combat	VB
cord-344093-3bniy5b5	32	25	influenza	influenza	NN
cord-344093-3bniy5b5	32	26	virus	virus	NN
cord-344093-3bniy5b5	32	27	infection	infection	NN
cord-344093-3bniy5b5	32	28	and	and	CC
cord-344093-3bniy5b5	32	29	named	name	VBN
cord-344093-3bniy5b5	32	30	this	this	DT
cord-344093-3bniy5b5	32	31	factor	factor	NN
cord-344093-3bniy5b5	32	32	interferon	interferon	NN
cord-344093-3bniy5b5	32	33	[	[	-LRB-
cord-344093-3bniy5b5	32	34	(	(	-LRB-
cord-344093-3bniy5b5	32	35	IFN	IFN	NNP
cord-344093-3bniy5b5	32	36	)	)	-RRB-
cord-344093-3bniy5b5	32	37	from	from	IN
cord-344093-3bniy5b5	32	38	latin	latin	JJ
cord-344093-3bniy5b5	32	39	interferre	interferre	NNP
cord-344093-3bniy5b5	32	40	,	,	,
cord-344093-3bniy5b5	32	41	to	to	TO
cord-344093-3bniy5b5	32	42	interfere	interfere	VB
cord-344093-3bniy5b5	32	43	]	]	-RRB-
cord-344093-3bniy5b5	32	44	.	.	.
cord-344093-3bniy5b5	33	1	Since	since	IN
cord-344093-3bniy5b5	33	2	then	then	RB
cord-344093-3bniy5b5	33	3	,	,	,
cord-344093-3bniy5b5	33	4	three	three	CD
cord-344093-3bniy5b5	33	5	subgroups	subgroup	NNS
cord-344093-3bniy5b5	33	6	of	of	IN
cord-344093-3bniy5b5	33	7	IFNs	ifn	NNS
cord-344093-3bniy5b5	33	8	have	have	VBP
cord-344093-3bniy5b5	33	9	been	be	VBN
cord-344093-3bniy5b5	33	10	defined	define	VBN
cord-344093-3bniy5b5	33	11	,	,	,
cord-344093-3bniy5b5	33	12	primarily	primarily	RB
cord-344093-3bniy5b5	33	13	by	by	IN
cord-344093-3bniy5b5	33	14	their	-PRON-	PRP$
cord-344093-3bniy5b5	33	15	differential	differential	JJ
cord-344093-3bniy5b5	33	16	receptor	receptor	NN
cord-344093-3bniy5b5	33	17	usage	usage	NN
cord-344093-3bniy5b5	33	18	.	.	.
cord-344093-3bniy5b5	34	1	While	while	IN
cord-344093-3bniy5b5	34	2	the	the	DT
cord-344093-3bniy5b5	34	3	groups	group	NNS
cord-344093-3bniy5b5	34	4	of	of	IN
cord-344093-3bniy5b5	34	5	type	type	NN
cord-344093-3bniy5b5	34	6	I	-PRON-	PRP
cord-344093-3bniy5b5	34	7	IFN	IFN	NNP
cord-344093-3bniy5b5	34	8	and	and	CC
cord-344093-3bniy5b5	34	9	type	type	NN
cord-344093-3bniy5b5	34	10	III	III	NNP
cord-344093-3bniy5b5	34	11	IFN	IFN	NNP
cord-344093-3bniy5b5	34	12	comprise	comprise	VBP
cord-344093-3bniy5b5	34	13	largely	largely	RB
cord-344093-3bniy5b5	34	14	agents	agent	NNS
cord-344093-3bniy5b5	34	15	directly	directly	RB
cord-344093-3bniy5b5	34	16	limiting	limit	VBG
cord-344093-3bniy5b5	34	17	pathogen	pathogen	NN
cord-344093-3bniy5b5	34	18	spread	spread	VBN
cord-344093-3bniy5b5	34	19	by	by	IN
cord-344093-3bniy5b5	34	20	improving	improve	VBG
cord-344093-3bniy5b5	34	21	cellular	cellular	JJ
cord-344093-3bniy5b5	34	22	counter	counter	NN
cord-344093-3bniy5b5	34	23	measurements	measurement	NNS
cord-344093-3bniy5b5	34	24	,	,	,
cord-344093-3bniy5b5	34	25	IFN	IFN	NNP
cord-344093-3bniy5b5	34	26	-	-	HYPH
cord-344093-3bniy5b5	34	27	γ	γ	NNP
cord-344093-3bniy5b5	34	28	,	,	,
cord-344093-3bniy5b5	34	29	the	the	DT
cord-344093-3bniy5b5	34	30	sole	sole	JJ
cord-344093-3bniy5b5	34	31	type	type	NN
cord-344093-3bniy5b5	34	32	II	II	NNP
cord-344093-3bniy5b5	34	33	IFN	IFN	NNP
cord-344093-3bniy5b5	34	34	,	,	,
cord-344093-3bniy5b5	34	35	has	have	VBZ
cord-344093-3bniy5b5	34	36	been	be	VBN
cord-344093-3bniy5b5	34	37	mainly	mainly	RB
cord-344093-3bniy5b5	34	38	implicated	implicate	VBN
cord-344093-3bniy5b5	34	39	in	in	IN
cord-344093-3bniy5b5	34	40	the	the	DT
cord-344093-3bniy5b5	34	41	modulation	modulation	NN
cord-344093-3bniy5b5	34	42	of	of	IN
cord-344093-3bniy5b5	34	43	innate	innate	JJ
cord-344093-3bniy5b5	34	44	and	and	CC
cord-344093-3bniy5b5	34	45	also	also	RB
cord-344093-3bniy5b5	34	46	adaptive	adaptive	JJ
cord-344093-3bniy5b5	34	47	immune	immune	JJ
cord-344093-3bniy5b5	34	48	responses	response	NNS
cord-344093-3bniy5b5	34	49	(	(	-LRB-
cord-344093-3bniy5b5	34	50	2	2	CD
cord-344093-3bniy5b5	34	51	,	,	,
cord-344093-3bniy5b5	34	52	3	3	CD
cord-344093-3bniy5b5	34	53	)	)	-RRB-
cord-344093-3bniy5b5	34	54	.	.	.
cord-344093-3bniy5b5	35	1	Accordingly	accordingly	RB
cord-344093-3bniy5b5	35	2	,	,	,
cord-344093-3bniy5b5	35	3	type	type	NN
cord-344093-3bniy5b5	35	4	I	-PRON-	PRP
cord-344093-3bniy5b5	35	5	and	and	CC
cord-344093-3bniy5b5	35	6	III	III	NNP
cord-344093-3bniy5b5	35	7	IFNs	ifn	NNS
cord-344093-3bniy5b5	35	8	are	be	VBP
cord-344093-3bniy5b5	35	9	key	key	JJ
cord-344093-3bniy5b5	35	10	signaling	signal	VBG
cord-344093-3bniy5b5	35	11	molecules	molecule	NNS
cord-344093-3bniy5b5	35	12	in	in	IN
cord-344093-3bniy5b5	35	13	viral	viral	JJ
cord-344093-3bniy5b5	35	14	control	control	NN
cord-344093-3bniy5b5	35	15	,	,	,
cord-344093-3bniy5b5	35	16	and	and	CC
cord-344093-3bniy5b5	35	17	lack	lack	NN
cord-344093-3bniy5b5	35	18	of	of	IN
cord-344093-3bniy5b5	35	19	both	both	DT
cord-344093-3bniy5b5	35	20	signaling	signal	VBG
cord-344093-3bniy5b5	35	21	pathways	pathway	NNS
cord-344093-3bniy5b5	35	22	results	result	NNS
cord-344093-3bniy5b5	35	23	in	in	IN
cord-344093-3bniy5b5	35	24	increased	increase	VBN
cord-344093-3bniy5b5	35	25	viral	viral	JJ
cord-344093-3bniy5b5	35	26	loads	load	NNS
cord-344093-3bniy5b5	35	27	and	and	CC
cord-344093-3bniy5b5	35	28	disease	disease	NN
cord-344093-3bniy5b5	35	29	severity	severity	NN
cord-344093-3bniy5b5	35	30	.	.	.
cord-344093-3bniy5b5	36	1	Still	still	RB
cord-344093-3bniy5b5	36	2	,	,	,
cord-344093-3bniy5b5	36	3	there	there	EX
cord-344093-3bniy5b5	36	4	is	be	VBZ
cord-344093-3bniy5b5	36	5	accumulating	accumulate	VBG
cord-344093-3bniy5b5	36	6	evidence	evidence	NN
cord-344093-3bniy5b5	36	7	that	that	IN
cord-344093-3bniy5b5	36	8	not	not	RB
cord-344093-3bniy5b5	36	9	only	only	RB
cord-344093-3bniy5b5	36	10	lack	lack	NN
cord-344093-3bniy5b5	36	11	of	of	IN
cord-344093-3bniy5b5	36	12	an	an	DT
cord-344093-3bniy5b5	36	13	antiviral	antiviral	JJ
cord-344093-3bniy5b5	36	14	response	response	NN
cord-344093-3bniy5b5	36	15	but	but	CC
cord-344093-3bniy5b5	36	16	that	that	IN
cord-344093-3bniy5b5	36	17	also	also	RB
cord-344093-3bniy5b5	36	18	an	an	DT
cord-344093-3bniy5b5	36	19	unbalanced	unbalanced	JJ
cord-344093-3bniy5b5	36	20	overshooting	overshoot	VBG
cord-344093-3bniy5b5	36	21	activation	activation	NN
cord-344093-3bniy5b5	36	22	of	of	IN
cord-344093-3bniy5b5	36	23	IFNs	ifns	NN
cord-344093-3bniy5b5	36	24	contributes	contribute	VBZ
cord-344093-3bniy5b5	36	25	to	to	IN
cord-344093-3bniy5b5	36	26	an	an	DT
cord-344093-3bniy5b5	36	27	exaggerated	exaggerated	JJ
cord-344093-3bniy5b5	36	28	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	36	29	reaction	reaction	NN
cord-344093-3bniy5b5	36	30	,	,	,
cord-344093-3bniy5b5	36	31	tissue	tissue	NN
cord-344093-3bniy5b5	36	32	injury	injury	NN
cord-344093-3bniy5b5	36	33	,	,	,
cord-344093-3bniy5b5	36	34	reduced	reduce	VBN
cord-344093-3bniy5b5	36	35	proliferative	proliferative	JJ
cord-344093-3bniy5b5	36	36	capacity	capacity	NN
cord-344093-3bniy5b5	36	37	,	,	,
cord-344093-3bniy5b5	36	38	and	and	CC
cord-344093-3bniy5b5	36	39	thus	thus	RB
cord-344093-3bniy5b5	36	40	enhanced	enhance	VBN
cord-344093-3bniy5b5	36	41	disease	disease	NN
cord-344093-3bniy5b5	36	42	severity	severity	NN
cord-344093-3bniy5b5	36	43	(	(	-LRB-
cord-344093-3bniy5b5	36	44	Table	table	NN
cord-344093-3bniy5b5	36	45	1	1	CD
cord-344093-3bniy5b5	36	46	)	)	-RRB-
cord-344093-3bniy5b5	36	47	.	.	.
cord-344093-3bniy5b5	37	1	Especially	especially	RB
cord-344093-3bniy5b5	37	2	in	in	IN
cord-344093-3bniy5b5	37	3	viral	viral	JJ
cord-344093-3bniy5b5	37	4	infections	infection	NNS
cord-344093-3bniy5b5	37	5	,	,	,
cord-344093-3bniy5b5	37	6	this	this	DT
cord-344093-3bniy5b5	37	7	effect	effect	NN
cord-344093-3bniy5b5	37	8	has	have	VBZ
cord-344093-3bniy5b5	37	9	not	not	RB
cord-344093-3bniy5b5	37	10	only	only	RB
cord-344093-3bniy5b5	37	11	been	be	VBN
cord-344093-3bniy5b5	37	12	tracked	track	VBN
cord-344093-3bniy5b5	37	13	down	down	RP
cord-344093-3bniy5b5	37	14	to	to	IN
cord-344093-3bniy5b5	37	15	IFN	IFN	NNP
cord-344093-3bniy5b5	37	16	signaling	signal	VBG
cord-344093-3bniy5b5	37	17	in	in	IN
cord-344093-3bniy5b5	37	18	general	general	JJ
cord-344093-3bniy5b5	37	19	but	but	CC
cord-344093-3bniy5b5	37	20	specifically	specifically	RB
cord-344093-3bniy5b5	37	21	to	to	IN
cord-344093-3bniy5b5	37	22	the	the	DT
cord-344093-3bniy5b5	37	23	exaggerated	exaggerated	JJ
cord-344093-3bniy5b5	37	24	production	production	NN
cord-344093-3bniy5b5	37	25	of	of	IN
cord-344093-3bniy5b5	37	26	key	key	JJ
cord-344093-3bniy5b5	37	27	effector	effector	NN
cord-344093-3bniy5b5	37	28	IFN	IFN	NNP
cord-344093-3bniy5b5	37	29	-	-	HYPH
cord-344093-3bniy5b5	37	30	stimulated	stimulate	VBN
cord-344093-3bniy5b5	37	31	genes	gene	NNS
cord-344093-3bniy5b5	37	32	(	(	-LRB-
cord-344093-3bniy5b5	37	33	ISGs	ISGs	NNP
cord-344093-3bniy5b5	37	34	)	)	-RRB-
cord-344093-3bniy5b5	37	35	(	(	-LRB-
cord-344093-3bniy5b5	37	36	4	4	LS
cord-344093-3bniy5b5	37	37	)	)	-RRB-
cord-344093-3bniy5b5	37	38	.	.	.
cord-344093-3bniy5b5	38	1	A	a	DT
cord-344093-3bniy5b5	38	2	prominent	prominent	JJ
cord-344093-3bniy5b5	38	3	example	example	NN
cord-344093-3bniy5b5	38	4	is	be	VBZ
cord-344093-3bniy5b5	38	5	the	the	DT
cord-344093-3bniy5b5	38	6	TNF	TNF	NNP
cord-344093-3bniy5b5	38	7	-	-	HYPH
cord-344093-3bniy5b5	38	8	related	relate	VBN
cord-344093-3bniy5b5	38	9	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	38	10	-	-	HYPH
cord-344093-3bniy5b5	38	11	inducing	induce	VBG
cord-344093-3bniy5b5	38	12	ligand	ligand	NN
cord-344093-3bniy5b5	38	13	(	(	-LRB-
cord-344093-3bniy5b5	38	14	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	38	15	)	)	-RRB-
cord-344093-3bniy5b5	38	16	that	that	WDT
cord-344093-3bniy5b5	38	17	displays	display	VBZ
cord-344093-3bniy5b5	38	18	an	an	DT
cord-344093-3bniy5b5	38	19	ambivalent	ambivalent	JJ
cord-344093-3bniy5b5	38	20	role	role	NN
cord-344093-3bniy5b5	38	21	in	in	IN
cord-344093-3bniy5b5	38	22	viral	viral	JJ
cord-344093-3bniy5b5	38	23	infection	infection	NN
cord-344093-3bniy5b5	38	24	(	(	-LRB-
cord-344093-3bniy5b5	38	25	5	5	CD
cord-344093-3bniy5b5	38	26	-	-	SYM
cord-344093-3bniy5b5	38	27	7	7	CD
cord-344093-3bniy5b5	38	28	)	)	-RRB-
cord-344093-3bniy5b5	38	29	(	(	-LRB-
cord-344093-3bniy5b5	38	30	Table	table	NN
cord-344093-3bniy5b5	38	31	1	1	CD
cord-344093-3bniy5b5	38	32	)	)	-RRB-
cord-344093-3bniy5b5	38	33	.	.	.
cord-344093-3bniy5b5	39	1	Whereas	whereas	IN
cord-344093-3bniy5b5	39	2	first	first	RB
cord-344093-3bniy5b5	39	3	identified	identify	VBN
cord-344093-3bniy5b5	39	4	as	as	IN
cord-344093-3bniy5b5	39	5	factor	factor	NN
cord-344093-3bniy5b5	39	6	produced	produce	VBN
cord-344093-3bniy5b5	39	7	by	by	IN
cord-344093-3bniy5b5	39	8	immune	immune	JJ
cord-344093-3bniy5b5	39	9	cells	cell	NNS
cord-344093-3bniy5b5	39	10	in	in	IN
cord-344093-3bniy5b5	39	11	non	non	JJ
cord-344093-3bniy5b5	39	12	-	-	JJ
cord-344093-3bniy5b5	39	13	respiratory	respiratory	JJ
cord-344093-3bniy5b5	39	14	infection	infection	NN
cord-344093-3bniy5b5	39	15	(	(	-LRB-
cord-344093-3bniy5b5	39	16	8	8	CD
cord-344093-3bniy5b5	39	17	,	,	,
cord-344093-3bniy5b5	39	18	9	9	CD
cord-344093-3bniy5b5	39	19	)	)	-RRB-
cord-344093-3bniy5b5	39	20	,	,	,
cord-344093-3bniy5b5	39	21	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	39	22	is	be	VBZ
cord-344093-3bniy5b5	39	23	now	now	RB
cord-344093-3bniy5b5	39	24	especially	especially	RB
cord-344093-3bniy5b5	39	25	well	well	RB
cord-344093-3bniy5b5	39	26	studied	study	VBN
cord-344093-3bniy5b5	39	27	in	in	IN
cord-344093-3bniy5b5	39	28	influenza	influenza	NN
cord-344093-3bniy5b5	39	29	A	a	DT
cord-344093-3bniy5b5	39	30	virus	virus	NN
cord-344093-3bniy5b5	39	31	(	(	-LRB-
cord-344093-3bniy5b5	39	32	IAV	iav	NN
cord-344093-3bniy5b5	39	33	)	)	-RRB-
cord-344093-3bniy5b5	39	34	infection	infection	NN
cord-344093-3bniy5b5	39	35	,	,	,
cord-344093-3bniy5b5	39	36	where	where	WRB
cord-344093-3bniy5b5	39	37	it	-PRON-	PRP
cord-344093-3bniy5b5	39	38	is	be	VBZ
cord-344093-3bniy5b5	39	39	released	release	VBN
cord-344093-3bniy5b5	39	40	in	in	IN
cord-344093-3bniy5b5	39	41	high	high	JJ
cord-344093-3bniy5b5	39	42	amounts	amount	NNS
cord-344093-3bniy5b5	39	43	from	from	IN
cord-344093-3bniy5b5	39	44	bone	bone	NN
cord-344093-3bniy5b5	39	45	marrow	marrow	NN
cord-344093-3bniy5b5	39	46	-	-	HYPH
cord-344093-3bniy5b5	39	47	derived	derive	VBN
cord-344093-3bniy5b5	39	48	macrophages	macrophage	NNS
cord-344093-3bniy5b5	39	49	upon	upon	IN
cord-344093-3bniy5b5	39	50	pathogenassociated	pathogenassociate	VBN
cord-344093-3bniy5b5	39	51	molecular	molecular	JJ
cord-344093-3bniy5b5	39	52	patterns	pattern	NNS
cord-344093-3bniy5b5	39	53	(	(	-LRB-
cord-344093-3bniy5b5	39	54	PAMPs	pamp	NNS
cord-344093-3bniy5b5	39	55	)	)	-RRB-
cord-344093-3bniy5b5	39	56	recognition	recognition	NN
cord-344093-3bniy5b5	39	57	and	and	CC
cord-344093-3bniy5b5	39	58	type	type	NN
cord-344093-3bniy5b5	40	1	I	-PRON-	PRP
cord-344093-3bniy5b5	40	2	IFN	IFN	NNP
cord-344093-3bniy5b5	40	3	production	production	NN
cord-344093-3bniy5b5	40	4	(	(	-LRB-
cord-344093-3bniy5b5	40	5	10	10	CD
cord-344093-3bniy5b5	40	6	)	)	-RRB-
cord-344093-3bniy5b5	40	7	.	.	.
cord-344093-3bniy5b5	41	1	Macrophage	macrophage	NN
cord-344093-3bniy5b5	41	2	-	-	HYPH
cord-344093-3bniy5b5	41	3	released	release	VBN
cord-344093-3bniy5b5	41	4	soluble	soluble	JJ
cord-344093-3bniy5b5	41	5	TRAIL	trail	NN
cord-344093-3bniy5b5	41	6	,	,	,
cord-344093-3bniy5b5	41	7	but	but	CC
cord-344093-3bniy5b5	41	8	also	also	RB
cord-344093-3bniy5b5	41	9	membrane	membrane	NN
cord-344093-3bniy5b5	41	10	-	-	HYPH
cord-344093-3bniy5b5	41	11	bound	bind	VBN
cord-344093-3bniy5b5	41	12	cell	cell	NN
cord-344093-3bniy5b5	41	13	-	-	HYPH
cord-344093-3bniy5b5	41	14	associated	associate	VBN
cord-344093-3bniy5b5	41	15	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	41	16	,	,	,
cord-344093-3bniy5b5	41	17	acts	act	VBZ
cord-344093-3bniy5b5	41	18	via	via	IN
cord-344093-3bniy5b5	41	19	distinct	distinct	JJ
cord-344093-3bniy5b5	41	20	receptors	receptor	NNS
cord-344093-3bniy5b5	41	21	on	on	IN
cord-344093-3bniy5b5	41	22	infected	infected	JJ
cord-344093-3bniy5b5	41	23	but	but	CC
cord-344093-3bniy5b5	41	24	also	also	RB
cord-344093-3bniy5b5	41	25	on	on	IN
cord-344093-3bniy5b5	41	26	non	non	JJ
cord-344093-3bniy5b5	41	27	-	-	JJ
cord-344093-3bniy5b5	41	28	infected	infected	JJ
cord-344093-3bniy5b5	41	29	,	,	,
cord-344093-3bniy5b5	41	30	neighboring	neighboring	NN
cord-344093-3bniy5b5	41	31	cells	cell	NNS
cord-344093-3bniy5b5	41	32	.	.	.
cord-344093-3bniy5b5	42	1	In	in	IN
cord-344093-3bniy5b5	42	2	viral	viral	JJ
cord-344093-3bniy5b5	42	3	infection	infection	NN
cord-344093-3bniy5b5	42	4	,	,	,
cord-344093-3bniy5b5	42	5	its	-PRON-	PRP$
cord-344093-3bniy5b5	42	6	preliminary	preliminary	JJ
cord-344093-3bniy5b5	42	7	role	role	NN
cord-344093-3bniy5b5	42	8	is	be	VBZ
cord-344093-3bniy5b5	42	9	to	to	TO
cord-344093-3bniy5b5	42	10	drive	drive	VB
cord-344093-3bniy5b5	42	11	infected	infected	JJ
cord-344093-3bniy5b5	42	12	cells	cell	NNS
cord-344093-3bniy5b5	42	13	into	into	IN
cord-344093-3bniy5b5	42	14	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	42	15	to	to	TO
cord-344093-3bniy5b5	42	16	limit	limit	VB
cord-344093-3bniy5b5	42	17	virus	virus	NN
cord-344093-3bniy5b5	42	18	spread	spread	VBN
cord-344093-3bniy5b5	42	19	.	.	.
cord-344093-3bniy5b5	43	1	However	however	RB
cord-344093-3bniy5b5	43	2	,	,	,
cord-344093-3bniy5b5	43	3	studies	study	NNS
cord-344093-3bniy5b5	43	4	performed	perform	VBN
cord-344093-3bniy5b5	43	5	within	within	IN
cord-344093-3bniy5b5	43	6	the	the	DT
cord-344093-3bniy5b5	43	7	last	last	JJ
cord-344093-3bniy5b5	43	8	decade	decade	NN
cord-344093-3bniy5b5	43	9	demonstrate	demonstrate	VBP
cord-344093-3bniy5b5	43	10	that	that	IN
cord-344093-3bniy5b5	43	11	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	43	12	's	's	POS
cord-344093-3bniy5b5	43	13	antiviral	antiviral	JJ
cord-344093-3bniy5b5	43	14	activity	activity	NN
cord-344093-3bniy5b5	43	15	seems	seem	VBZ
cord-344093-3bniy5b5	43	16	to	to	TO
cord-344093-3bniy5b5	43	17	be	be	VB
cord-344093-3bniy5b5	43	18	outweighed	outweigh	VBN
cord-344093-3bniy5b5	43	19	by	by	IN
cord-344093-3bniy5b5	43	20	the	the	DT
cord-344093-3bniy5b5	43	21	functional	functional	JJ
cord-344093-3bniy5b5	43	22	and	and	CC
cord-344093-3bniy5b5	43	23	structural	structural	JJ
cord-344093-3bniy5b5	43	24	damage	damage	NN
cord-344093-3bniy5b5	43	25	it	-PRON-	PRP
cord-344093-3bniy5b5	43	26	induces	induce	VBZ
cord-344093-3bniy5b5	43	27	not	not	RB
cord-344093-3bniy5b5	43	28	only	only	RB
cord-344093-3bniy5b5	43	29	in	in	IN
cord-344093-3bniy5b5	43	30	infected	infected	JJ
cord-344093-3bniy5b5	43	31	but	but	CC
cord-344093-3bniy5b5	43	32	also	also	RB
cord-344093-3bniy5b5	43	33	in	in	IN
cord-344093-3bniy5b5	43	34	bystander	bystander	NN
cord-344093-3bniy5b5	43	35	cells	cell	NNS
cord-344093-3bniy5b5	43	36	such	such	JJ
cord-344093-3bniy5b5	43	37	as	as	IN
cord-344093-3bniy5b5	43	38	uninfected	uninfected	JJ
cord-344093-3bniy5b5	43	39	cells	cell	NNS
cord-344093-3bniy5b5	43	40	of	of	IN
cord-344093-3bniy5b5	43	41	the	the	DT
cord-344093-3bniy5b5	43	42	alveolar	alveolar	JJ
cord-344093-3bniy5b5	43	43	epithelium	epithelium	NN
cord-344093-3bniy5b5	43	44	(	(	-LRB-
cord-344093-3bniy5b5	43	45	10	10	CD
cord-344093-3bniy5b5	43	46	,	,	,
cord-344093-3bniy5b5	43	47	11	11	CD
cord-344093-3bniy5b5	43	48	)	)	-RRB-
cord-344093-3bniy5b5	43	49	.	.	.
cord-344093-3bniy5b5	44	1	This	this	DT
cord-344093-3bniy5b5	44	2	process	process	NN
cord-344093-3bniy5b5	44	3	is	be	VBZ
cord-344093-3bniy5b5	44	4	not	not	RB
cord-344093-3bniy5b5	44	5	only	only	RB
cord-344093-3bniy5b5	44	6	relevant	relevant	JJ
cord-344093-3bniy5b5	44	7	in	in	IN
cord-344093-3bniy5b5	44	8	promoting	promote	VBG
cord-344093-3bniy5b5	44	9	viral	viral	JJ
cord-344093-3bniy5b5	44	10	disease	disease	NN
cord-344093-3bniy5b5	44	11	progression	progression	NN
cord-344093-3bniy5b5	44	12	but	but	CC
cord-344093-3bniy5b5	44	13	has	have	VBZ
cord-344093-3bniy5b5	44	14	further	further	JJ
cord-344093-3bniy5b5	44	15	implications	implication	NNS
cord-344093-3bniy5b5	44	16	in	in	IN
cord-344093-3bniy5b5	44	17	bacterial	bacterial	JJ
cord-344093-3bniy5b5	44	18	superinfection	superinfection	NN
cord-344093-3bniy5b5	44	19	and	and	CC
cord-344093-3bniy5b5	44	20	probably	probably	RB
cord-344093-3bniy5b5	44	21	also	also	RB
cord-344093-3bniy5b5	44	22	in	in	IN
cord-344093-3bniy5b5	44	23	chronic	chronic	JJ
cord-344093-3bniy5b5	44	24	diseases	disease	NNS
cord-344093-3bniy5b5	44	25	.	.	.
cord-344093-3bniy5b5	45	1	The	the	DT
cord-344093-3bniy5b5	45	2	recognition	recognition	NN
cord-344093-3bniy5b5	45	3	of	of	IN
cord-344093-3bniy5b5	45	4	the	the	DT
cord-344093-3bniy5b5	45	5	ambivalent	ambivalent	JJ
cord-344093-3bniy5b5	45	6	role	role	NN
cord-344093-3bniy5b5	45	7	of	of	IN
cord-344093-3bniy5b5	45	8	IFN	IFN	NNP
cord-344093-3bniy5b5	45	9	-	-	HYPH
cord-344093-3bniy5b5	45	10	driven	drive	VBN
cord-344093-3bniy5b5	45	11	signaling	signal	VBG
cord-344093-3bniy5b5	45	12	in	in	IN
cord-344093-3bniy5b5	45	13	vivo	vivo	NN
cord-344093-3bniy5b5	45	14	is	be	VBZ
cord-344093-3bniy5b5	45	15	a	a	DT
cord-344093-3bniy5b5	45	16	first	first	JJ
cord-344093-3bniy5b5	45	17	important	important	JJ
cord-344093-3bniy5b5	45	18	step	step	NN
cord-344093-3bniy5b5	45	19	to	to	TO
cord-344093-3bniy5b5	45	20	better	better	RB
cord-344093-3bniy5b5	45	21	understand	understand	VB
cord-344093-3bniy5b5	45	22	disease	disease	NN
cord-344093-3bniy5b5	45	23	progression	progression	NN
cord-344093-3bniy5b5	45	24	and	and	CC
cord-344093-3bniy5b5	45	25	to	to	TO
cord-344093-3bniy5b5	45	26	envision	envision	VB
cord-344093-3bniy5b5	45	27	novel	novel	JJ
cord-344093-3bniy5b5	45	28	treatment	treatment	NN
cord-344093-3bniy5b5	45	29	options	option	NNS
cord-344093-3bniy5b5	45	30	for	for	IN
cord-344093-3bniy5b5	45	31	primary	primary	JJ
cord-344093-3bniy5b5	45	32	viral	viral	JJ
cord-344093-3bniy5b5	45	33	respiratory	respiratory	JJ
cord-344093-3bniy5b5	45	34	infection	infection	NN
cord-344093-3bniy5b5	45	35	targeting	target	VBG
cord-344093-3bniy5b5	45	36	distinct	distinct	JJ
cord-344093-3bniy5b5	45	37	host	host	NN
cord-344093-3bniy5b5	45	38	-	-	HYPH
cord-344093-3bniy5b5	45	39	derived	derive	VBN
cord-344093-3bniy5b5	45	40	signaling	signal	VBG
cord-344093-3bniy5b5	45	41	mediators	mediator	NNS
cord-344093-3bniy5b5	45	42	such	such	JJ
cord-344093-3bniy5b5	45	43	as	as	IN
cord-344093-3bniy5b5	45	44	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	45	45	.	.	.
cord-344093-3bniy5b5	46	1	It	-PRON-	PRP
cord-344093-3bniy5b5	46	2	is	be	VBZ
cord-344093-3bniy5b5	46	3	a	a	DT
cord-344093-3bniy5b5	46	4	commonly	commonly	RB
cord-344093-3bniy5b5	46	5	accepted	accept	VBN
cord-344093-3bniy5b5	46	6	concept	concept	NN
cord-344093-3bniy5b5	46	7	that	that	IN
cord-344093-3bniy5b5	46	8	-	-	:
cord-344093-3bniy5b5	46	9	as	as	IN
cord-344093-3bniy5b5	46	10	Janeway	Janeway	NNP
cord-344093-3bniy5b5	46	11	(	(	-LRB-
cord-344093-3bniy5b5	46	12	12	12	CD
cord-344093-3bniy5b5	46	13	)	)	-RRB-
cord-344093-3bniy5b5	46	14	already	already	RB
cord-344093-3bniy5b5	46	15	proposed	propose	VBN
cord-344093-3bniy5b5	46	16	in	in	IN
cord-344093-3bniy5b5	46	17	1989-immune	1989-immune	CD
cord-344093-3bniy5b5	46	18	activation	activation	NN
cord-344093-3bniy5b5	46	19	toward	toward	IN
cord-344093-3bniy5b5	46	20	invading	invade	VBG
cord-344093-3bniy5b5	46	21	pathogens	pathogen	NNS
cord-344093-3bniy5b5	46	22	is	be	VBZ
cord-344093-3bniy5b5	46	23	mounted	mount	VBN
cord-344093-3bniy5b5	46	24	upon	upon	IN
cord-344093-3bniy5b5	46	25	recognition	recognition	NN
cord-344093-3bniy5b5	46	26	of	of	IN
cord-344093-3bniy5b5	46	27	PAMPs	pamp	NNS
cord-344093-3bniy5b5	46	28	.	.	.
cord-344093-3bniy5b5	47	1	PAMPs	pamp	NNS
cord-344093-3bniy5b5	47	2	are	be	VBP
cord-344093-3bniy5b5	47	3	evolutionary	evolutionary	JJ
cord-344093-3bniy5b5	47	4	conserved	conserve	VBN
cord-344093-3bniy5b5	47	5	biomolecules	biomolecule	NNS
cord-344093-3bniy5b5	47	6	such	such	JJ
cord-344093-3bniy5b5	47	7	as	as	IN
cord-344093-3bniy5b5	47	8	proteins	protein	NNS
cord-344093-3bniy5b5	47	9	,	,	,
cord-344093-3bniy5b5	47	10	lipids	lipid	NNS
cord-344093-3bniy5b5	47	11	,	,	,
cord-344093-3bniy5b5	47	12	nitrogen	nitrogen	NN
cord-344093-3bniy5b5	47	13	bases	basis	NNS
cord-344093-3bniy5b5	47	14	,	,	,
cord-344093-3bniy5b5	47	15	sugars	sugar	NNS
cord-344093-3bniy5b5	47	16	,	,	,
cord-344093-3bniy5b5	47	17	and	and	CC
cord-344093-3bniy5b5	47	18	complexed	complexe	VBN
cord-344093-3bniy5b5	47	19	biomolecules	biomolecule	NNS
cord-344093-3bniy5b5	47	20	such	such	JJ
cord-344093-3bniy5b5	47	21	as	as	IN
cord-344093-3bniy5b5	47	22	lipoglycans	lipoglycan	NNS
cord-344093-3bniy5b5	47	23	that	that	WDT
cord-344093-3bniy5b5	47	24	are	be	VBP
cord-344093-3bniy5b5	47	25	essential	essential	JJ
cord-344093-3bniy5b5	47	26	to	to	IN
cord-344093-3bniy5b5	47	27	the	the	DT
cord-344093-3bniy5b5	47	28	survival	survival	NN
cord-344093-3bniy5b5	47	29	of	of	IN
cord-344093-3bniy5b5	47	30	a	a	DT
cord-344093-3bniy5b5	47	31	given	give	VBN
cord-344093-3bniy5b5	47	32	pathogen	pathogen	NN
cord-344093-3bniy5b5	47	33	(	(	-LRB-
cord-344093-3bniy5b5	47	34	13	13	CD
cord-344093-3bniy5b5	47	35	)	)	-RRB-
cord-344093-3bniy5b5	47	36	.	.	.
cord-344093-3bniy5b5	48	1	PAMPs	pamp	NNS
cord-344093-3bniy5b5	48	2	are	be	VBP
cord-344093-3bniy5b5	48	3	recognized	recognize	VBN
cord-344093-3bniy5b5	48	4	by	by	IN
cord-344093-3bniy5b5	48	5	distinct	distinct	JJ
cord-344093-3bniy5b5	48	6	pattern	pattern	NN
cord-344093-3bniy5b5	48	7	recognition	recognition	NN
cord-344093-3bniy5b5	48	8	receptors	receptor	NNS
cord-344093-3bniy5b5	48	9	(	(	-LRB-
cord-344093-3bniy5b5	48	10	PRRs	PRRs	NNP
cord-344093-3bniy5b5	48	11	)	)	-RRB-
cord-344093-3bniy5b5	48	12	that	that	WDT
cord-344093-3bniy5b5	48	13	are	be	VBP
cord-344093-3bniy5b5	48	14	germ	germ	NN
cord-344093-3bniy5b5	48	15	-	-	HYPH
cord-344093-3bniy5b5	48	16	line	line	NN
cord-344093-3bniy5b5	48	17	encoded	encode	VBN
cord-344093-3bniy5b5	48	18	and	and	CC
cord-344093-3bniy5b5	48	19	-	-	HYPH
cord-344093-3bniy5b5	48	20	similar	similar	JJ
cord-344093-3bniy5b5	48	21	to	to	IN
cord-344093-3bniy5b5	48	22	PAMPs	pamp	NNS
cord-344093-3bniy5b5	48	23	-	-	:
cord-344093-3bniy5b5	48	24	usually	usually	RB
cord-344093-3bniy5b5	48	25	show	show	VBP
cord-344093-3bniy5b5	48	26	a	a	DT
cord-344093-3bniy5b5	48	27	high	high	JJ
cord-344093-3bniy5b5	48	28	evolutionary	evolutionary	JJ
cord-344093-3bniy5b5	48	29	conservation	conservation	NN
cord-344093-3bniy5b5	48	30	.	.	.
cord-344093-3bniy5b5	49	1	The	the	DT
cord-344093-3bniy5b5	49	2	first	first	JJ
cord-344093-3bniy5b5	49	3	recognized	recognize	VBN
cord-344093-3bniy5b5	49	4	and	and	CC
cord-344093-3bniy5b5	49	5	probably	probably	RB
cord-344093-3bniy5b5	49	6	most	most	RBS
cord-344093-3bniy5b5	49	7	intensely	intensely	RB
cord-344093-3bniy5b5	49	8	studied	study	VBN
cord-344093-3bniy5b5	49	9	family	family	NN
cord-344093-3bniy5b5	49	10	of	of	IN
cord-344093-3bniy5b5	49	11	PRRs	PRRs	NNP
cord-344093-3bniy5b5	49	12	are	be	VBP
cord-344093-3bniy5b5	49	13	the	the	DT
cord-344093-3bniy5b5	49	14	toll	toll	NN
cord-344093-3bniy5b5	49	15	-	-	HYPH
cord-344093-3bniy5b5	49	16	like	like	JJ
cord-344093-3bniy5b5	49	17	receptors	receptor	NNS
cord-344093-3bniy5b5	49	18	[	[	-LRB-
cord-344093-3bniy5b5	49	19	TLRs	tlr	NNS
cord-344093-3bniy5b5	49	20	;	;	,
cord-344093-3bniy5b5	49	21	reviewed	review	VBN
cord-344093-3bniy5b5	49	22	in	in	IN
cord-344093-3bniy5b5	49	23	Mogensen	Mogensen	NNP
cord-344093-3bniy5b5	49	24	(	(	-LRB-
cord-344093-3bniy5b5	49	25	14	14	CD
cord-344093-3bniy5b5	49	26	)	)	-RRB-
cord-344093-3bniy5b5	49	27	;	;	:
cord-344093-3bniy5b5	49	28	Leifer	Leifer	NNP
cord-344093-3bniy5b5	49	29	and	and	CC
cord-344093-3bniy5b5	49	30	Medvedev	Medvedev	NNP
cord-344093-3bniy5b5	49	31	(	(	-LRB-
cord-344093-3bniy5b5	49	32	15	15	CD
cord-344093-3bniy5b5	49	33	)	)	-RRB-
cord-344093-3bniy5b5	49	34	]	]	-RRB-
cord-344093-3bniy5b5	49	35	.	.	.
cord-344093-3bniy5b5	50	1	In	in	IN
cord-344093-3bniy5b5	50	2	viral	viral	JJ
cord-344093-3bniy5b5	50	3	infection	infection	NN
cord-344093-3bniy5b5	50	4	,	,	,
cord-344093-3bniy5b5	50	5	both	both	DT
cord-344093-3bniy5b5	50	6	host	host	NN
cord-344093-3bniy5b5	50	7	cell	cell	NN
cord-344093-3bniy5b5	50	8	membrane	membrane	NN
cord-344093-3bniy5b5	50	9	-	-	HYPH
cord-344093-3bniy5b5	50	10	localized	localize	VBN
cord-344093-3bniy5b5	50	11	TLRs	tlr	NNS
cord-344093-3bniy5b5	50	12	(	(	-LRB-
cord-344093-3bniy5b5	50	13	TLR2	TLR2	NNP
cord-344093-3bniy5b5	50	14	,	,	,
cord-344093-3bniy5b5	50	15	TLR4	TLR4	NNP
cord-344093-3bniy5b5	50	16	,	,	,
cord-344093-3bniy5b5	50	17	detecting	detect	VBG
cord-344093-3bniy5b5	50	18	viral	viral	JJ
cord-344093-3bniy5b5	50	19	envelope	envelope	NN
cord-344093-3bniy5b5	50	20	proteins	protein	NNS
cord-344093-3bniy5b5	50	21	)	)	-RRB-
cord-344093-3bniy5b5	50	22	and	and	CC
cord-344093-3bniy5b5	50	23	endosomal	endosomal	NNP
cord-344093-3bniy5b5	50	24	TLRs	TLRs	NNP
cord-344093-3bniy5b5	50	25	(	(	-LRB-
cord-344093-3bniy5b5	50	26	TLR3	TLR3	NNP
cord-344093-3bniy5b5	50	27	,	,	,
cord-344093-3bniy5b5	50	28	TLR7	TLR7	NNP
cord-344093-3bniy5b5	50	29	,	,	,
cord-344093-3bniy5b5	50	30	TLR8	TLR8	NNP
cord-344093-3bniy5b5	50	31	,	,	,
cord-344093-3bniy5b5	50	32	and	and	CC
cord-344093-3bniy5b5	50	33	 	 	_SP
cord-344093-3bniy5b5	50	34	TLR9	TLR9	NNP
cord-344093-3bniy5b5	50	35	,	,	,
cord-344093-3bniy5b5	50	36	nucleic	nucleic	JJ
cord-344093-3bniy5b5	50	37	acid	acid	NN
cord-344093-3bniy5b5	50	38	sensors	sensor	NNS
cord-344093-3bniy5b5	50	39	)	)	-RRB-
cord-344093-3bniy5b5	50	40	initiate	initiate	VBP
cord-344093-3bniy5b5	50	41	signal	signal	NN
cord-344093-3bniy5b5	50	42	transduction	transduction	NN
cord-344093-3bniy5b5	50	43	cascades	cascade	NNS
cord-344093-3bniy5b5	50	44	leading	lead	VBG
cord-344093-3bniy5b5	50	45	to	to	IN
cord-344093-3bniy5b5	50	46	IFN	IFN	NNP
cord-344093-3bniy5b5	50	47	production	production	NN
cord-344093-3bniy5b5	50	48	(	(	-LRB-
cord-344093-3bniy5b5	50	49	Figure	figure	NN
cord-344093-3bniy5b5	50	50	1	1	CD
cord-344093-3bniy5b5	50	51	)	)	-RRB-
cord-344093-3bniy5b5	50	52	.	.	.
cord-344093-3bniy5b5	51	1	TLR	TLR	NNP
cord-344093-3bniy5b5	51	2	activation	activation	NN
cord-344093-3bniy5b5	51	3	results	result	NNS
cord-344093-3bniy5b5	51	4	in	in	IN
cord-344093-3bniy5b5	51	5	either	either	DT
cord-344093-3bniy5b5	51	6	myeloid	myeloid	JJ
cord-344093-3bniy5b5	51	7	differentiation	differentiation	NN
cord-344093-3bniy5b5	51	8	factor	factor	NN
cord-344093-3bniy5b5	51	9	88	88	CD
cord-344093-3bniy5b5	51	10	(	(	-LRB-
cord-344093-3bniy5b5	51	11	MyD88	MyD88	NNS
cord-344093-3bniy5b5	51	12	)	)	-RRB-
cord-344093-3bniy5b5	51	13	or	or	CC
cord-344093-3bniy5b5	51	14	TIR	TIR	NNP
cord-344093-3bniy5b5	51	15	-	-	HYPH
cord-344093-3bniy5b5	51	16	domaincontaining	domaincontaining	NN
cord-344093-3bniy5b5	51	17	adaptor	adaptor	NN
cord-344093-3bniy5b5	51	18	protein	protein	NN
cord-344093-3bniy5b5	51	19	-	-	HYPH
cord-344093-3bniy5b5	51	20	inducing	induce	VBG
cord-344093-3bniy5b5	51	21	IFN	IFN	NNP
cord-344093-3bniy5b5	51	22	-	-	HYPH
cord-344093-3bniy5b5	51	23	β	β	NNP
cord-344093-3bniy5b5	51	24	(	(	-LRB-
cord-344093-3bniy5b5	51	25	TRIF	TRIF	NNP
cord-344093-3bniy5b5	51	26	)	)	-RRB-
cord-344093-3bniy5b5	51	27	recruitment	recruitment	NN
cord-344093-3bniy5b5	51	28	that	that	WDT
cord-344093-3bniy5b5	51	29	both	both	DT
cord-344093-3bniy5b5	51	30	trigger	trigger	VBP
cord-344093-3bniy5b5	51	31	various	various	JJ
cord-344093-3bniy5b5	51	32	downstream	downstream	NN
cord-344093-3bniy5b5	51	33	signaling	signal	VBG
cord-344093-3bniy5b5	51	34	events	event	NNS
cord-344093-3bniy5b5	51	35	,	,	,
cord-344093-3bniy5b5	51	36	eventually	eventually	RB
cord-344093-3bniy5b5	51	37	leading	lead	VBG
cord-344093-3bniy5b5	51	38	to	to	IN
cord-344093-3bniy5b5	51	39	IFN	IFN	NNP
cord-344093-3bniy5b5	51	40	regulatory	regulatory	JJ
cord-344093-3bniy5b5	51	41	factor	factor	NN
cord-344093-3bniy5b5	51	42	(	(	-LRB-
cord-344093-3bniy5b5	51	43	IRF)3	IRF)3	''
cord-344093-3bniy5b5	51	44	,	,	,
cord-344093-3bniy5b5	51	45	IRF7	IRF7	NNP
cord-344093-3bniy5b5	51	46	,	,	,
cord-344093-3bniy5b5	51	47	and	and	CC
cord-344093-3bniy5b5	51	48	NFκB	NFκB	NNP
cord-344093-3bniy5b5	51	49	nuclear	nuclear	JJ
cord-344093-3bniy5b5	51	50	translocation	translocation	NN
cord-344093-3bniy5b5	51	51	as	as	RB
cord-344093-3bniy5b5	51	52	well	well	RB
cord-344093-3bniy5b5	51	53	as	as	IN
cord-344093-3bniy5b5	51	54	MAP	map	NN
cord-344093-3bniy5b5	51	55	kinase	kinase	NN
cord-344093-3bniy5b5	51	56	and	and	CC
cord-344093-3bniy5b5	51	57	activator	activator	NN
cord-344093-3bniy5b5	51	58	protein	protein	NN
cord-344093-3bniy5b5	51	59	1	1	CD
cord-344093-3bniy5b5	51	60	(	(	-LRB-
cord-344093-3bniy5b5	51	61	AP-1	AP-1	NNP
cord-344093-3bniy5b5	51	62	)	)	-RRB-
cord-344093-3bniy5b5	51	63	activation	activation	NN
cord-344093-3bniy5b5	51	64	(	(	-LRB-
cord-344093-3bniy5b5	51	65	16	16	CD
cord-344093-3bniy5b5	51	66	,	,	,
cord-344093-3bniy5b5	51	67	17	17	CD
cord-344093-3bniy5b5	51	68	)	)	-RRB-
cord-344093-3bniy5b5	51	69	.	.	.
cord-344093-3bniy5b5	52	1	Similar	similar	JJ
cord-344093-3bniy5b5	52	2	to	to	IN
cord-344093-3bniy5b5	52	3	endosomal	endosomal	NNP
cord-344093-3bniy5b5	52	4	TLRs	TLRs	NNP
cord-344093-3bniy5b5	52	5	,	,	,
cord-344093-3bniy5b5	52	6	the	the	DT
cord-344093-3bniy5b5	52	7	cytosolic	cytosolic	JJ
cord-344093-3bniy5b5	52	8	retinoic	retinoic	JJ
cord-344093-3bniy5b5	52	9	acidinducible	acidinducible	NN
cord-344093-3bniy5b5	52	10	gene	gene	NN
cord-344093-3bniy5b5	52	11	(	(	-LRB-
cord-344093-3bniy5b5	52	12	RIG)-I	RIG)-I	NNP
cord-344093-3bniy5b5	52	13	-	-	HYPH
cord-344093-3bniy5b5	52	14	like	like	JJ
cord-344093-3bniy5b5	52	15	receptors	receptor	NNS
cord-344093-3bniy5b5	52	16	(	(	-LRB-
cord-344093-3bniy5b5	52	17	RLRs	rlr	NNS
cord-344093-3bniy5b5	52	18	)	)	-RRB-
cord-344093-3bniy5b5	52	19	are	be	VBP
cord-344093-3bniy5b5	52	20	specialized	specialize	VBN
cord-344093-3bniy5b5	52	21	to	to	TO
cord-344093-3bniy5b5	52	22	recognize	recognize	VB
cord-344093-3bniy5b5	52	23	viral	viral	JJ
cord-344093-3bniy5b5	52	24	nucleic	nucleic	JJ
cord-344093-3bniy5b5	52	25	acid	acid	NN
cord-344093-3bniy5b5	52	26	contents	content	NNS
cord-344093-3bniy5b5	52	27	and	and	CC
cord-344093-3bniy5b5	52	28	are	be	VBP
cord-344093-3bniy5b5	52	29	central	central	JJ
cord-344093-3bniy5b5	52	30	PRRs	PRRs	NNPS
cord-344093-3bniy5b5	52	31	relevant	relevant	JJ
cord-344093-3bniy5b5	52	32	to	to	TO
cord-344093-3bniy5b5	52	33	mount	mount	VB
cord-344093-3bniy5b5	52	34	an	an	DT
cord-344093-3bniy5b5	52	35	antiviral	antiviral	JJ
cord-344093-3bniy5b5	52	36	response	response	NN
cord-344093-3bniy5b5	52	37	,	,	,
cord-344093-3bniy5b5	52	38	providing	provide	VBG
cord-344093-3bniy5b5	52	39	resistance	resistance	NN
cord-344093-3bniy5b5	52	40	to	to	IN
cord-344093-3bniy5b5	52	41	most	most	JJS
cord-344093-3bniy5b5	52	42	RNA	RNA	NNP
cord-344093-3bniy5b5	52	43	(	(	-LRB-
cord-344093-3bniy5b5	52	44	e.g.	e.g.	RB
cord-344093-3bniy5b5	52	45	,	,	,
cord-344093-3bniy5b5	52	46	orthomyxoviruses	orthomyxoviruses	NNP
cord-344093-3bniy5b5	52	47	)	)	-RRB-
cord-344093-3bniy5b5	52	48	and	and	CC
cord-344093-3bniy5b5	52	49	some	some	DT
cord-344093-3bniy5b5	52	50	DNA	dna	NN
cord-344093-3bniy5b5	52	51	(	(	-LRB-
cord-344093-3bniy5b5	52	52	e.g.	e.g.	RB
cord-344093-3bniy5b5	52	53	,	,	,
cord-344093-3bniy5b5	52	54	reoviruses	reovirus	NNS
cord-344093-3bniy5b5	52	55	)	)	-RRB-
cord-344093-3bniy5b5	52	56	viruses	virus	NNS
cord-344093-3bniy5b5	52	57	[	[	-LRB-
cord-344093-3bniy5b5	52	58	reviewed	review	VBN
cord-344093-3bniy5b5	52	59	in	in	IN
cord-344093-3bniy5b5	52	60	Ref	Ref	NNP
cord-344093-3bniy5b5	52	61	.	.	.
cord-344093-3bniy5b5	53	1	(	(	-LRB-
cord-344093-3bniy5b5	53	2	18	18	CD
cord-344093-3bniy5b5	53	3	,	,	,
cord-344093-3bniy5b5	53	4	19	19	CD
cord-344093-3bniy5b5	53	5	)	)	-RRB-
cord-344093-3bniy5b5	53	6	]	]	-RRB-
cord-344093-3bniy5b5	53	7	.	.	.
cord-344093-3bniy5b5	54	1	Both	both	DT
cord-344093-3bniy5b5	54	2	melanoma	melanoma	NN
cord-344093-3bniy5b5	54	3	differentiation	differentiation	NN
cord-344093-3bniy5b5	54	4	-	-	HYPH
cord-344093-3bniy5b5	54	5	associated	associate	VBN
cord-344093-3bniy5b5	54	6	gene	gene	NN
cord-344093-3bniy5b5	54	7	5	5	CD
cord-344093-3bniy5b5	54	8	(	(	-LRB-
cord-344093-3bniy5b5	54	9	MDA-5	MDA-5	NNP
cord-344093-3bniy5b5	54	10	)	)	-RRB-
cord-344093-3bniy5b5	54	11	and	and	CC
cord-344093-3bniy5b5	54	12	RIG	rig	NN
cord-344093-3bniy5b5	55	1	-I	-i	WDT
cord-344093-3bniy5b5	55	2	recognize	recognize	VBP
cord-344093-3bniy5b5	55	3	dsRNA	dsrna	NN
cord-344093-3bniy5b5	55	4	,	,	,
cord-344093-3bniy5b5	55	5	5′-triphosphate	5′-triphosphate	CD
cord-344093-3bniy5b5	55	6	RNA	RNA	NNP
cord-344093-3bniy5b5	55	7	,	,	,
cord-344093-3bniy5b5	55	8	or	or	CC
cord-344093-3bniy5b5	55	9	the	the	DT
cord-344093-3bniy5b5	55	10	synthetic	synthetic	JJ
cord-344093-3bniy5b5	55	11	analog	analog	NN
cord-344093-3bniy5b5	55	12	to	to	IN
cord-344093-3bniy5b5	55	13	dsRNA	dsrna	NN
cord-344093-3bniy5b5	55	14	,	,	,
cord-344093-3bniy5b5	55	15	polyI	polyI	NNP
cord-344093-3bniy5b5	55	16	:	:	:
cord-344093-3bniy5b5	55	17	C	C	NNP
cord-344093-3bniy5b5	55	18	(	(	-LRB-
cord-344093-3bniy5b5	55	19	20	20	CD
cord-344093-3bniy5b5	55	20	,	,	,
cord-344093-3bniy5b5	55	21	21	21	CD
cord-344093-3bniy5b5	55	22	)	)	-RRB-
cord-344093-3bniy5b5	55	23	.	.	.
cord-344093-3bniy5b5	56	1	Both	both	DT
cord-344093-3bniy5b5	56	2	drive	drive	VB
cord-344093-3bniy5b5	56	3	the	the	DT
cord-344093-3bniy5b5	56	4	dimerization	dimerization	NN
cord-344093-3bniy5b5	56	5	of	of	IN
cord-344093-3bniy5b5	56	6	the	the	DT
cord-344093-3bniy5b5	56	7	mitochondriaassociated	mitochondriaassociated	JJ
cord-344093-3bniy5b5	56	8	adaptor	adaptor	NN
cord-344093-3bniy5b5	56	9	protein	protein	NN
cord-344093-3bniy5b5	56	10	IFN	IFN	NNP
cord-344093-3bniy5b5	56	11	-	-	HYPH
cord-344093-3bniy5b5	56	12	β	β	NNP
cord-344093-3bniy5b5	56	13	promoter	promoter	NN
cord-344093-3bniy5b5	56	14	stimulation	stimulation	NN
cord-344093-3bniy5b5	56	15	1	1	CD
cord-344093-3bniy5b5	57	1	(	(	-LRB-
cord-344093-3bniy5b5	57	2	IPS-1	IPS-1	NNP
cord-344093-3bniy5b5	57	3	)	)	-RRB-
cord-344093-3bniy5b5	57	4	(	(	-LRB-
cord-344093-3bniy5b5	57	5	also	also	RB
cord-344093-3bniy5b5	57	6	named	name	VBN
cord-344093-3bniy5b5	57	7	MAVS	MAVS	NNP
cord-344093-3bniy5b5	57	8	,	,	,
cord-344093-3bniy5b5	57	9	VISA	VISA	NNP
cord-344093-3bniy5b5	57	10	,	,	,
cord-344093-3bniy5b5	57	11	CARDIF	CARDIF	NNP
cord-344093-3bniy5b5	57	12	)	)	-RRB-
cord-344093-3bniy5b5	57	13	.	.	.
cord-344093-3bniy5b5	58	1	A	a	DT
cord-344093-3bniy5b5	58	2	subsequently	subsequently	RB
cord-344093-3bniy5b5	58	3	activated	activate	VBN
cord-344093-3bniy5b5	58	4	cascade	cascade	NN
cord-344093-3bniy5b5	58	5	including	include	VBG
cord-344093-3bniy5b5	58	6	TRADD	TRADD	NNP
cord-344093-3bniy5b5	58	7	(	(	-LRB-
cord-344093-3bniy5b5	58	8	TNF	TNF	NNP
cord-344093-3bniy5b5	58	9	receptor	receptor	NN
cord-344093-3bniy5b5	58	10	type	type	NN
cord-344093-3bniy5b5	58	11	1-associated	1-associated	CD
cord-344093-3bniy5b5	58	12	death	death	NN
cord-344093-3bniy5b5	58	13	domain	domain	NN
cord-344093-3bniy5b5	58	14	protein	protein	NN
cord-344093-3bniy5b5	58	15	)	)	-RRB-
cord-344093-3bniy5b5	58	16	,	,	.
cord-344093-3bniy5b5	59	1	TRAF3	TRAF3	NNP
cord-344093-3bniy5b5	60	1	(	(	-LRB-
cord-344093-3bniy5b5	60	2	TNF	TNF	NNP
cord-344093-3bniy5b5	60	3	receptor	receptor	NN
cord-344093-3bniy5b5	60	4	-	-	HYPH
cord-344093-3bniy5b5	60	5	associated	associate	VBN
cord-344093-3bniy5b5	60	6	factor	factor	NN
cord-344093-3bniy5b5	60	7	3	3	CD
cord-344093-3bniy5b5	60	8	)	)	-RRB-
cord-344093-3bniy5b5	60	9	,	,	,
cord-344093-3bniy5b5	60	10	and	and	CC
cord-344093-3bniy5b5	60	11	TANK	tank	NN
cord-344093-3bniy5b5	60	12	(	(	-LRB-
cord-344093-3bniy5b5	60	13	TRAF	TRAF	NNP
cord-344093-3bniy5b5	60	14	family	family	NN
cord-344093-3bniy5b5	60	15	member	member	NN
cord-344093-3bniy5b5	60	16	-	-	HYPH
cord-344093-3bniy5b5	60	17	associated	associate	VBN
cord-344093-3bniy5b5	60	18	NF	NF	NNP
cord-344093-3bniy5b5	60	19	-	-	HYPH
cord-344093-3bniy5b5	60	20	κB	κb	CD
cord-344093-3bniy5b5	60	21	activator	activator	NN
cord-344093-3bniy5b5	60	22	)	)	-RRB-
cord-344093-3bniy5b5	60	23	induces	induce	VBZ
cord-344093-3bniy5b5	60	24	the	the	DT
cord-344093-3bniy5b5	60	25	phosphorylation	phosphorylation	NN
cord-344093-3bniy5b5	60	26	of	of	IN
cord-344093-3bniy5b5	60	27	IRF3	IRF3	NNP
cord-344093-3bniy5b5	60	28	and	and	CC
cord-344093-3bniy5b5	60	29	IRF7	IRF7	NNP
cord-344093-3bniy5b5	60	30	,	,	,
cord-344093-3bniy5b5	60	31	resulting	result	VBG
cord-344093-3bniy5b5	60	32	in	in	IN
cord-344093-3bniy5b5	60	33	type	type	NN
cord-344093-3bniy5b5	60	34	I	-PRON-	PRP
cord-344093-3bniy5b5	60	35	IFN	IFN	NNP
cord-344093-3bniy5b5	60	36	production	production	NN
cord-344093-3bniy5b5	60	37	(	(	-LRB-
cord-344093-3bniy5b5	60	38	22	22	CD
cord-344093-3bniy5b5	60	39	)	)	-RRB-
cord-344093-3bniy5b5	60	40	.	.	.
cord-344093-3bniy5b5	61	1	The	the	DT
cord-344093-3bniy5b5	61	2	third	third	JJ
cord-344093-3bniy5b5	61	3	RLR	RLR	NNP
cord-344093-3bniy5b5	61	4	,	,	,
cord-344093-3bniy5b5	61	5	LGP2	LGP2	NNP
cord-344093-3bniy5b5	61	6	,	,	,
cord-344093-3bniy5b5	61	7	so	so	RB
cord-344093-3bniy5b5	61	8	far	far	RB
cord-344093-3bniy5b5	61	9	has	have	VBZ
cord-344093-3bniy5b5	61	10	primarily	primarily	RB
cord-344093-3bniy5b5	61	11	been	be	VBN
cord-344093-3bniy5b5	61	12	implicated	implicate	VBN
cord-344093-3bniy5b5	61	13	to	to	TO
cord-344093-3bniy5b5	61	14	regulate	regulate	VB
cord-344093-3bniy5b5	61	15	RIG	rig	NN
cord-344093-3bniy5b5	61	16	-	-	:
cord-344093-3bniy5b5	61	17	I	-PRON-	PRP
cord-344093-3bniy5b5	61	18	or	or	CC
cord-344093-3bniy5b5	61	19	MDA-5	MDA-5	NNP
cord-344093-3bniy5b5	61	20	as	as	IN
cord-344093-3bniy5b5	61	21	a	a	DT
cord-344093-3bniy5b5	61	22	cofactor	cofactor	NN
cord-344093-3bniy5b5	61	23	;	;	:
cord-344093-3bniy5b5	61	24	however	however	RB
cord-344093-3bniy5b5	61	25	,	,	,
cord-344093-3bniy5b5	61	26	a	a	DT
cord-344093-3bniy5b5	61	27	recent	recent	JJ
cord-344093-3bniy5b5	61	28	study	study	NN
cord-344093-3bniy5b5	61	29	by	by	IN
cord-344093-3bniy5b5	61	30	Stone	Stone	NNP
cord-344093-3bniy5b5	61	31	et	et	NNP
cord-344093-3bniy5b5	61	32	al	al	NNP
cord-344093-3bniy5b5	61	33	.	.	.
cord-344093-3bniy5b5	62	1	(	(	-LRB-
cord-344093-3bniy5b5	62	2	23	23	CD
cord-344093-3bniy5b5	62	3	)	)	-RRB-
cord-344093-3bniy5b5	62	4	demonstrated	demonstrate	VBD
cord-344093-3bniy5b5	62	5	a	a	DT
cord-344093-3bniy5b5	62	6	novel	novel	NN
cord-344093-3bniy5b5	62	7	,	,	,
cord-344093-3bniy5b5	62	8	non	non	JJ
cord-344093-3bniy5b5	62	9	-	-	JJ
cord-344093-3bniy5b5	62	10	redundant	redundant	JJ
cord-344093-3bniy5b5	62	11	,	,	,
cord-344093-3bniy5b5	62	12	and	and	CC
cord-344093-3bniy5b5	62	13	independent	independent	JJ
cord-344093-3bniy5b5	62	14	role	role	NN
cord-344093-3bniy5b5	62	15	of	of	IN
cord-344093-3bniy5b5	62	16	LGP2	LGP2	NNP
cord-344093-3bniy5b5	62	17	in	in	IN
cord-344093-3bniy5b5	62	18	West	West	NNP
cord-344093-3bniy5b5	62	19	Nile	Nile	NNP
cord-344093-3bniy5b5	62	20	virus	virus	NN
cord-344093-3bniy5b5	62	21	infection	infection	NN
cord-344093-3bniy5b5	62	22	.	.	.
cord-344093-3bniy5b5	63	1	Another	another	DT
cord-344093-3bniy5b5	63	2	class	class	NN
cord-344093-3bniy5b5	63	3	of	of	IN
cord-344093-3bniy5b5	63	4	PRR	PRR	NNP
cord-344093-3bniy5b5	63	5	,	,	,
cord-344093-3bniy5b5	63	6	the	the	DT
cord-344093-3bniy5b5	63	7	nucleotide	nucleotide	JJ
cord-344093-3bniy5b5	63	8	oligomerization	oligomerization	NN
cord-344093-3bniy5b5	63	9	domain	domain	NN
cord-344093-3bniy5b5	63	10	(	(	-LRB-
cord-344093-3bniy5b5	63	11	NOD)-like	nod)-like	CD
cord-344093-3bniy5b5	63	12	receptors	receptor	NNS
cord-344093-3bniy5b5	63	13	(	(	-LRB-
cord-344093-3bniy5b5	63	14	NLRs	NLRs	NNP
cord-344093-3bniy5b5	63	15	)	)	-RRB-
cord-344093-3bniy5b5	63	16	,	,	,
cord-344093-3bniy5b5	63	17	has	have	VBZ
cord-344093-3bniy5b5	63	18	mainly	mainly	RB
cord-344093-3bniy5b5	63	19	been	be	VBN
cord-344093-3bniy5b5	63	20	implicated	implicate	VBN
cord-344093-3bniy5b5	63	21	in	in	IN
cord-344093-3bniy5b5	63	22	bacterial	bacterial	JJ
cord-344093-3bniy5b5	63	23	recognition	recognition	NN
cord-344093-3bniy5b5	63	24	(	(	-LRB-
cord-344093-3bniy5b5	63	25	24	24	CD
cord-344093-3bniy5b5	63	26	)	)	-RRB-
cord-344093-3bniy5b5	63	27	,	,	,
cord-344093-3bniy5b5	63	28	still	still	RB
cord-344093-3bniy5b5	63	29	several	several	JJ
cord-344093-3bniy5b5	63	30	NLRs	nlr	NNS
cord-344093-3bniy5b5	63	31	are	be	VBP
cord-344093-3bniy5b5	63	32	activated	activate	VBN
cord-344093-3bniy5b5	63	33	as	as	RB
cord-344093-3bniy5b5	63	34	well	well	RB
cord-344093-3bniy5b5	63	35	upon	upon	IN
cord-344093-3bniy5b5	63	36	virus	virus	NN
cord-344093-3bniy5b5	63	37	infection	infection	NN
cord-344093-3bniy5b5	63	38	.	.	.
cord-344093-3bniy5b5	64	1	Especially	especially	RB
cord-344093-3bniy5b5	64	2	,	,	,
cord-344093-3bniy5b5	64	3	NLRP3	NLRP3	NNP
cord-344093-3bniy5b5	64	4	is	be	VBZ
cord-344093-3bniy5b5	64	5	known	know	VBN
cord-344093-3bniy5b5	64	6	to	to	TO
cord-344093-3bniy5b5	64	7	recognize	recognize	VB
cord-344093-3bniy5b5	64	8	RNA	RNA	NNP
cord-344093-3bniy5b5	64	9	of	of	IN
cord-344093-3bniy5b5	64	10	different	different	JJ
cord-344093-3bniy5b5	64	11	viruses	virus	NNS
cord-344093-3bniy5b5	64	12	including	include	VBG
cord-344093-3bniy5b5	64	13	hepatitis	hepatitis	NN
cord-344093-3bniy5b5	64	14	C	C	NNP
cord-344093-3bniy5b5	64	15	virus	virus	NN
cord-344093-3bniy5b5	64	16	,	,	,
cord-344093-3bniy5b5	64	17	measles	measles	NN
cord-344093-3bniy5b5	64	18	virus	virus	NN
cord-344093-3bniy5b5	64	19	,	,	,
cord-344093-3bniy5b5	64	20	influenza	influenza	NN
cord-344093-3bniy5b5	64	21	,	,	,
cord-344093-3bniy5b5	64	22	and	and	CC
cord-344093-3bniy5b5	64	23	vesicular	vesicular	JJ
cord-344093-3bniy5b5	64	24	stomatitis	stomatitis	NN
cord-344093-3bniy5b5	64	25	virus	virus	NN
cord-344093-3bniy5b5	64	26	(	(	-LRB-
cord-344093-3bniy5b5	64	27	VSV	VSV	NNP
cord-344093-3bniy5b5	64	28	)	)	-RRB-
cord-344093-3bniy5b5	64	29	(	(	-LRB-
cord-344093-3bniy5b5	64	30	25	25	CD
cord-344093-3bniy5b5	64	31	)	)	-RRB-
cord-344093-3bniy5b5	64	32	(	(	-LRB-
cord-344093-3bniy5b5	64	33	26	26	CD
cord-344093-3bniy5b5	64	34	)	)	-RRB-
cord-344093-3bniy5b5	64	35	(	(	-LRB-
cord-344093-3bniy5b5	64	36	27	27	CD
cord-344093-3bniy5b5	64	37	)	)	-RRB-
cord-344093-3bniy5b5	64	38	(	(	-LRB-
cord-344093-3bniy5b5	64	39	28	28	CD
cord-344093-3bniy5b5	64	40	)	)	-RRB-
cord-344093-3bniy5b5	64	41	,	,	,
cord-344093-3bniy5b5	64	42	resulting	result	VBG
cord-344093-3bniy5b5	64	43	in	in	IN
cord-344093-3bniy5b5	64	44	inflammasome	inflammasome	NN
cord-344093-3bniy5b5	64	45	formation	formation	NN
cord-344093-3bniy5b5	64	46	and	and	CC
cord-344093-3bniy5b5	64	47	caspase-1-dependent	caspase-1-dependent	NNP
cord-344093-3bniy5b5	64	48	activation	activation	NN
cord-344093-3bniy5b5	64	49	of	of	IN
cord-344093-3bniy5b5	64	50	IL-1β	il-1β	NN
cord-344093-3bniy5b5	64	51	and	and	CC
cord-344093-3bniy5b5	64	52	IL-18	IL-18	NNP
cord-344093-3bniy5b5	64	53	(	(	-LRB-
cord-344093-3bniy5b5	64	54	29	29	CD
cord-344093-3bniy5b5	64	55	)	)	-RRB-
cord-344093-3bniy5b5	64	56	(	(	-LRB-
cord-344093-3bniy5b5	64	57	30	30	CD
cord-344093-3bniy5b5	64	58	)	)	-RRB-
cord-344093-3bniy5b5	64	59	(	(	-LRB-
cord-344093-3bniy5b5	64	60	31	31	CD
cord-344093-3bniy5b5	64	61	)	)	-RRB-
cord-344093-3bniy5b5	64	62	.	.	.
cord-344093-3bniy5b5	65	1	In	in	IN
cord-344093-3bniy5b5	65	2	addition	addition	NN
cord-344093-3bniy5b5	65	3	,	,	,
cord-344093-3bniy5b5	65	4	virus	virus	NN
cord-344093-3bniy5b5	65	5	infections	infection	NNS
cord-344093-3bniy5b5	65	6	are	be	VBP
cord-344093-3bniy5b5	65	7	sensed	sense	VBN
cord-344093-3bniy5b5	65	8	also	also	RB
cord-344093-3bniy5b5	65	9	by	by	IN
cord-344093-3bniy5b5	65	10	a	a	DT
cord-344093-3bniy5b5	65	11	structurally	structurally	RB
cord-344093-3bniy5b5	65	12	diverse	diverse	JJ
cord-344093-3bniy5b5	65	13	group	group	NN
cord-344093-3bniy5b5	65	14	of	of	IN
cord-344093-3bniy5b5	65	15	viral	viral	JJ
cord-344093-3bniy5b5	65	16	RNA	RNA	NNP
cord-344093-3bniy5b5	65	17	and	and	CC
cord-344093-3bniy5b5	65	18	DNA	dna	NN
cord-344093-3bniy5b5	65	19	sensors	sensor	NNS
cord-344093-3bniy5b5	65	20	residing	reside	VBG
cord-344093-3bniy5b5	65	21	in	in	IN
cord-344093-3bniy5b5	65	22	the	the	DT
cord-344093-3bniy5b5	65	23	cytoplasm	cytoplasm	NN
cord-344093-3bniy5b5	65	24	.	.	.
cord-344093-3bniy5b5	66	1	These	these	DT
cord-344093-3bniy5b5	66	2	include	include	VBP
cord-344093-3bniy5b5	66	3	the	the	DT
cord-344093-3bniy5b5	66	4	cyclic	cyclic	JJ
cord-344093-3bniy5b5	66	5	GMP	GMP	NNP
cord-344093-3bniy5b5	66	6	-	-	HYPH
cord-344093-3bniy5b5	66	7	AMP	AMP	NNP
cord-344093-3bniy5b5	66	8	synthase	synthase	NN
cord-344093-3bniy5b5	66	9	that	that	WDT
cord-344093-3bniy5b5	66	10	synthesizes	synthesize	VBZ
cord-344093-3bniy5b5	66	11	the	the	DT
cord-344093-3bniy5b5	66	12	second	second	JJ
cord-344093-3bniy5b5	66	13	messenger	messenger	NN
cord-344093-3bniy5b5	66	14	cGAMP	cGAMP	NNP
cord-344093-3bniy5b5	66	15	.	.	.
cord-344093-3bniy5b5	67	1	cGAMP	cGAMP	NNP
cord-344093-3bniy5b5	68	1	in	in	IN
cord-344093-3bniy5b5	68	2	turn	turn	NN
cord-344093-3bniy5b5	68	3	activates	activate	VBZ
cord-344093-3bniy5b5	68	4	stimulator	stimulator	NN
cord-344093-3bniy5b5	68	5	of	of	IN
cord-344093-3bniy5b5	68	6	IFN	IFN	NNP
cord-344093-3bniy5b5	68	7	genes	gene	NNS
cord-344093-3bniy5b5	68	8	(	(	-LRB-
cord-344093-3bniy5b5	68	9	STING	STING	NNP
cord-344093-3bniy5b5	68	10	)	)	-RRB-
cord-344093-3bniy5b5	68	11	,	,	,
cord-344093-3bniy5b5	68	12	TANK	tank	NN
cord-344093-3bniy5b5	68	13	-	-	HYPH
cord-344093-3bniy5b5	68	14	binding	bind	VBG
cord-344093-3bniy5b5	68	15	kinase	kinase	NN
cord-344093-3bniy5b5	68	16	1	1	CD
cord-344093-3bniy5b5	68	17	,	,	,
cord-344093-3bniy5b5	68	18	and	and	CC
cord-344093-3bniy5b5	68	19	IRF3	IRF3	NNP
cord-344093-3bniy5b5	68	20	,	,	,
cord-344093-3bniy5b5	68	21	triggering	trigger	VBG
cord-344093-3bniy5b5	68	22	IFN	IFN	NNP
cord-344093-3bniy5b5	68	23	production	production	NN
cord-344093-3bniy5b5	68	24	(	(	-LRB-
cord-344093-3bniy5b5	68	25	32	32	CD
cord-344093-3bniy5b5	68	26	)	)	-RRB-
cord-344093-3bniy5b5	68	27	(	(	-LRB-
cord-344093-3bniy5b5	68	28	33	33	CD
cord-344093-3bniy5b5	68	29	)	)	-RRB-
cord-344093-3bniy5b5	68	30	(	(	-LRB-
cord-344093-3bniy5b5	68	31	34	34	CD
cord-344093-3bniy5b5	68	32	)	)	-RRB-
cord-344093-3bniy5b5	68	33	.	.	.
cord-344093-3bniy5b5	69	1	Moreover	moreover	RB
cord-344093-3bniy5b5	69	2	,	,	,
cord-344093-3bniy5b5	69	3	STING	sting	VB
cord-344093-3bniy5b5	69	4	itself	-PRON-	PRP
cord-344093-3bniy5b5	69	5	acts	act	VBZ
cord-344093-3bniy5b5	69	6	as	as	IN
cord-344093-3bniy5b5	69	7	a	a	DT
cord-344093-3bniy5b5	69	8	PRR	PRR	NNP
cord-344093-3bniy5b5	69	9	and	and	CC
cord-344093-3bniy5b5	69	10	has	have	VBZ
cord-344093-3bniy5b5	69	11	been	be	VBN
cord-344093-3bniy5b5	69	12	implicated	implicate	VBN
cord-344093-3bniy5b5	69	13	in	in	IN
cord-344093-3bniy5b5	69	14	DNA	dna	NN
cord-344093-3bniy5b5	69	15	virus	virus	NN
cord-344093-3bniy5b5	69	16	recognition	recognition	NN
cord-344093-3bniy5b5	69	17	including	include	VBG
cord-344093-3bniy5b5	69	18	HSV	HSV	NNP
cord-344093-3bniy5b5	69	19	,	,	,
cord-344093-3bniy5b5	69	20	adenovirus	adenovirus	NN
cord-344093-3bniy5b5	69	21	,	,	,
cord-344093-3bniy5b5	69	22	vaccinia	vaccinia	NN
cord-344093-3bniy5b5	69	23	virus	virus	NN
cord-344093-3bniy5b5	69	24	,	,	,
cord-344093-3bniy5b5	69	25	and	and	CC
cord-344093-3bniy5b5	69	26	papilloma	papilloma	NN
cord-344093-3bniy5b5	69	27	virus	virus	NN
cord-344093-3bniy5b5	69	28	and	and	CC
cord-344093-3bniy5b5	69	29	in	in	IN
cord-344093-3bniy5b5	69	30	sensing	sensing	NN
cord-344093-3bniy5b5	69	31	of	of	IN
cord-344093-3bniy5b5	69	32	retroviral	retroviral	JJ
cord-344093-3bniy5b5	69	33	RNA	RNA	NNP
cord-344093-3bniy5b5	69	34	-	-	HYPH
cord-344093-3bniy5b5	69	35	DNA	dna	NN
cord-344093-3bniy5b5	69	36	hybrids	hybrid	NNS
cord-344093-3bniy5b5	69	37	(	(	-LRB-
cord-344093-3bniy5b5	69	38	35	35	CD
cord-344093-3bniy5b5	69	39	)	)	-RRB-
cord-344093-3bniy5b5	69	40	and	and	CC
cord-344093-3bniy5b5	69	41	RNA	RNA	NNP
cord-344093-3bniy5b5	69	42	viruses	virus	NNS
cord-344093-3bniy5b5	69	43	after	after	IN
cord-344093-3bniy5b5	69	44	being	be	VBG
cord-344093-3bniy5b5	69	45	activated	activate	VBN
cord-344093-3bniy5b5	69	46	by	by	IN
cord-344093-3bniy5b5	69	47	RIG	rig	NN
cord-344093-3bniy5b5	69	48	-	-	:
cord-344093-3bniy5b5	69	49	I	i	NN
cord-344093-3bniy5b5	69	50	(	(	-LRB-
cord-344093-3bniy5b5	69	51	36	36	CD
cord-344093-3bniy5b5	69	52	,	,	,
cord-344093-3bniy5b5	69	53	37	37	CD
cord-344093-3bniy5b5	69	54	)	)	-RRB-
cord-344093-3bniy5b5	69	55	.	.	.
cord-344093-3bniy5b5	70	1	Another	another	DT
cord-344093-3bniy5b5	70	2	cytosolic	cytosolic	JJ
cord-344093-3bniy5b5	70	3	nucleic	nucleic	JJ
cord-344093-3bniy5b5	70	4	acid	acid	NN
cord-344093-3bniy5b5	70	5	sensor	sensor	NN
cord-344093-3bniy5b5	70	6	,	,	,
cord-344093-3bniy5b5	70	7	PKR	PKR	NNP
cord-344093-3bniy5b5	70	8	,	,	,
cord-344093-3bniy5b5	70	9	is	be	VBZ
cord-344093-3bniy5b5	70	10	well	well	RB
cord-344093-3bniy5b5	70	11	known	know	VBN
cord-344093-3bniy5b5	70	12	for	for	IN
cord-344093-3bniy5b5	70	13	its	-PRON-	PRP$
cord-344093-3bniy5b5	70	14	phosphorylation	phosphorylation	NN
cord-344093-3bniy5b5	70	15	of	of	IN
cord-344093-3bniy5b5	70	16	eukaryotic	eukaryotic	JJ
cord-344093-3bniy5b5	70	17	initiation	initiation	NN
cord-344093-3bniy5b5	70	18	factor	factor	NN
cord-344093-3bniy5b5	70	19	2	2	CD
cord-344093-3bniy5b5	70	20	α	α	NN
cord-344093-3bniy5b5	70	21	(	(	-LRB-
cord-344093-3bniy5b5	70	22	eIF2α	eIF2α	NNP
cord-344093-3bniy5b5	70	23	)	)	-RRB-
cord-344093-3bniy5b5	70	24	in	in	IN
cord-344093-3bniy5b5	70	25	response	response	NN
cord-344093-3bniy5b5	70	26	to	to	IN
cord-344093-3bniy5b5	70	27	viral	viral	JJ
cord-344093-3bniy5b5	70	28	dsRNA	dsrna	NN
cord-344093-3bniy5b5	70	29	.	.	.
cord-344093-3bniy5b5	71	1	Phosphorylation	Phosphorylation	NNP
cord-344093-3bniy5b5	71	2	of	of	IN
cord-344093-3bniy5b5	71	3	eIF2α	eif2α	JJ
cord-344093-3bniy5b5	71	4	results	result	NNS
cord-344093-3bniy5b5	71	5	in	in	IN
cord-344093-3bniy5b5	71	6	its	-PRON-	PRP$
cord-344093-3bniy5b5	71	7	deactivation	deactivation	NN
cord-344093-3bniy5b5	71	8	,	,	,
cord-344093-3bniy5b5	71	9	host	host	NN
cord-344093-3bniy5b5	71	10	translational	translational	JJ
cord-344093-3bniy5b5	71	11	shut	shut	NN
cord-344093-3bniy5b5	71	12	-	-	HYPH
cord-344093-3bniy5b5	71	13	off	off	NN
cord-344093-3bniy5b5	71	14	,	,	,
cord-344093-3bniy5b5	71	15	and	and	CC
cord-344093-3bniy5b5	71	16	the	the	DT
cord-344093-3bniy5b5	71	17	limitation	limitation	NN
cord-344093-3bniy5b5	71	18	of	of	IN
cord-344093-3bniy5b5	71	19	viral	viral	JJ
cord-344093-3bniy5b5	71	20	replication	replication	NN
cord-344093-3bniy5b5	71	21	.	.	.
cord-344093-3bniy5b5	72	1	Of	of	IN
cord-344093-3bniy5b5	72	2	note	note	NN
cord-344093-3bniy5b5	72	3	,	,	,
cord-344093-3bniy5b5	72	4	the	the	DT
cord-344093-3bniy5b5	72	5	PKR	PKR	NNP
cord-344093-3bniy5b5	72	6	-	-	HYPH
cord-344093-3bniy5b5	72	7	eIF2α	eif2α	RB
cord-344093-3bniy5b5	72	8	-	-	HYPH
cord-344093-3bniy5b5	72	9	driven	drive	VBN
cord-344093-3bniy5b5	72	10	inhibition	inhibition	NN
cord-344093-3bniy5b5	72	11	of	of	IN
cord-344093-3bniy5b5	72	12	protein	protein	NN
cord-344093-3bniy5b5	72	13	synthesis	synthesis	NN
cord-344093-3bniy5b5	72	14	can	can	MD
cord-344093-3bniy5b5	72	15	contribute	contribute	VB
cord-344093-3bniy5b5	72	16	to	to	IN
cord-344093-3bniy5b5	72	17	an	an	DT
cord-344093-3bniy5b5	72	18	IPS-1-dependent	ips-1-dependent	NN
cord-344093-3bniy5b5	72	19	IFN	IFN	NNP
cord-344093-3bniy5b5	72	20	-	-	HYPH
cord-344093-3bniy5b5	72	21	β	β	NNP
cord-344093-3bniy5b5	72	22	induction	induction	NN
cord-344093-3bniy5b5	72	23	(	(	-LRB-
cord-344093-3bniy5b5	72	24	38	38	CD
cord-344093-3bniy5b5	72	25	)	)	-RRB-
cord-344093-3bniy5b5	72	26	.	.	.
cord-344093-3bniy5b5	73	1	Furthermore	furthermore	RB
cord-344093-3bniy5b5	73	2	,	,	,
cord-344093-3bniy5b5	73	3	PKR	PKR	NNP
cord-344093-3bniy5b5	73	4	has	have	VBZ
cord-344093-3bniy5b5	73	5	been	be	VBN
cord-344093-3bniy5b5	73	6	implicated	implicate	VBN
cord-344093-3bniy5b5	73	7	in	in	IN
cord-344093-3bniy5b5	73	8	efficient	efficient	JJ
cord-344093-3bniy5b5	73	9	type	type	NN
cord-344093-3bniy5b5	74	1	I	-PRON-	PRP
cord-344093-3bniy5b5	74	2	IFN	IFN	NNP
cord-344093-3bniy5b5	74	3	activation	activation	NN
cord-344093-3bniy5b5	74	4	by	by	IN
cord-344093-3bniy5b5	74	5	TLR3	TLR3	NNP
cord-344093-3bniy5b5	74	6	in	in	IN
cord-344093-3bniy5b5	74	7	response	response	NN
cord-344093-3bniy5b5	74	8	to	to	IN
cord-344093-3bniy5b5	74	9	dsRNA	dsrna	NN
cord-344093-3bniy5b5	74	10	(	(	-LRB-
cord-344093-3bniy5b5	74	11	39	39	CD
cord-344093-3bniy5b5	74	12	)	)	-RRB-
cord-344093-3bniy5b5	74	13	and	and	CC
cord-344093-3bniy5b5	74	14	can	can	MD
cord-344093-3bniy5b5	74	15	mediate	mediate	VB
cord-344093-3bniy5b5	74	16	-	-	:
cord-344093-3bniy5b5	74	17	at	at	RB
cord-344093-3bniy5b5	74	18	least	least	JJS
cord-344093-3bniy5b5	74	19	partially	partially	RB
cord-344093-3bniy5b5	74	20	-	-	:
cord-344093-3bniy5b5	74	21	activities	activity	NNS
cord-344093-3bniy5b5	74	22	of	of	IN
cord-344093-3bniy5b5	74	23	IRF1	IRF1	NNP
cord-344093-3bniy5b5	74	24	(	(	-LRB-
cord-344093-3bniy5b5	74	25	40	40	CD
cord-344093-3bniy5b5	74	26	)	)	-RRB-
cord-344093-3bniy5b5	74	27	.	.	.
cord-344093-3bniy5b5	75	1	In	in	IN
cord-344093-3bniy5b5	75	2	addition	addition	NN
cord-344093-3bniy5b5	75	3	to	to	TO
cord-344093-3bniy5b5	75	4	type	type	NN
cord-344093-3bniy5b5	75	5	I	-PRON-	PRP
cord-344093-3bniy5b5	75	6	IFNs	ifn	NNS
cord-344093-3bniy5b5	75	7	,	,	,
cord-344093-3bniy5b5	75	8	also	also	RB
cord-344093-3bniy5b5	75	9	type	type	NN
cord-344093-3bniy5b5	75	10	III	iii	CD
cord-344093-3bniy5b5	75	11	IFNs	ifn	NNS
cord-344093-3bniy5b5	75	12	exert	exert	VB
cord-344093-3bniy5b5	75	13	antiviral	antiviral	JJ
cord-344093-3bniy5b5	75	14	activity	activity	NN
cord-344093-3bniy5b5	75	15	and	and	CC
cord-344093-3bniy5b5	75	16	are	be	VBP
cord-344093-3bniy5b5	75	17	widely	widely	RB
cord-344093-3bniy5b5	75	18	expressed	express	VBN
cord-344093-3bniy5b5	75	19	after	after	IN
cord-344093-3bniy5b5	75	20	viral	viral	JJ
cord-344093-3bniy5b5	75	21	recognition	recognition	NN
cord-344093-3bniy5b5	75	22	,	,	,
cord-344093-3bniy5b5	75	23	being	be	VBG
cord-344093-3bniy5b5	75	24	produced	produce	VBN
cord-344093-3bniy5b5	75	25	by	by	IN
cord-344093-3bniy5b5	75	26	most	most	JJS
cord-344093-3bniy5b5	75	27	cell	cell	NN
cord-344093-3bniy5b5	75	28	types	type	NNS
cord-344093-3bniy5b5	75	29	including	include	VBG
cord-344093-3bniy5b5	75	30	epithelial	epithelial	JJ
cord-344093-3bniy5b5	75	31	,	,	,
cord-344093-3bniy5b5	75	32	endothelial	endothelial	JJ
cord-344093-3bniy5b5	75	33	,	,	,
cord-344093-3bniy5b5	75	34	fibroblast	fibroblast	NN
cord-344093-3bniy5b5	75	35	,	,	,
cord-344093-3bniy5b5	75	36	and	and	CC
cord-344093-3bniy5b5	75	37	polymorphonuclear	polymorphonuclear	NN
cord-344093-3bniy5b5	75	38	cells	cell	NNS
cord-344093-3bniy5b5	75	39	[	[	-LRB-
cord-344093-3bniy5b5	75	40	reviewed	review	VBN
cord-344093-3bniy5b5	75	41	in	in	IN
cord-344093-3bniy5b5	75	42	Ref	Ref	NNP
cord-344093-3bniy5b5	75	43	.	.	.
cord-344093-3bniy5b5	76	1	(	(	-LRB-
cord-344093-3bniy5b5	76	2	41	41	CD
cord-344093-3bniy5b5	76	3	,	,	,
cord-344093-3bniy5b5	76	4	42	42	CD
cord-344093-3bniy5b5	76	5	)	)	-RRB-
cord-344093-3bniy5b5	76	6	]	]	-RRB-
cord-344093-3bniy5b5	76	7	.	.	.
cord-344093-3bniy5b5	77	1	Like	like	IN
cord-344093-3bniy5b5	77	2	type	type	NN
cord-344093-3bniy5b5	77	3	I	-PRON-	PRP
cord-344093-3bniy5b5	77	4	IFNs	ifns	NN
cord-344093-3bniy5b5	77	5	,	,	,
cord-344093-3bniy5b5	77	6	type	type	NN
cord-344093-3bniy5b5	77	7	III	iii	CD
cord-344093-3bniy5b5	77	8	IFNs	ifn	NNS
cord-344093-3bniy5b5	77	9	are	be	VBP
cord-344093-3bniy5b5	77	10	induced	induce	VBN
cord-344093-3bniy5b5	77	11	in	in	IN
cord-344093-3bniy5b5	77	12	viral	viral	JJ
cord-344093-3bniy5b5	77	13	infection	infection	NN
cord-344093-3bniy5b5	77	14	by	by	IN
cord-344093-3bniy5b5	77	15	the	the	DT
cord-344093-3bniy5b5	77	16	PRR	PRR	NNP
cord-344093-3bniy5b5	77	17	RIG-	RIG-	NNP
cord-344093-3bniy5b5	78	1	I	-PRON-	PRP
cord-344093-3bniy5b5	78	2	as	as	RB
cord-344093-3bniy5b5	78	3	well	well	RB
cord-344093-3bniy5b5	78	4	as	as	IN
cord-344093-3bniy5b5	78	5	TLR3	TLR3	NNP
cord-344093-3bniy5b5	78	6	and	and	CC
cord-344093-3bniy5b5	78	7	TLR9	TLR9	NNP
cord-344093-3bniy5b5	78	8	and	and	CC
cord-344093-3bniy5b5	78	9	rely	rely	VB
cord-344093-3bniy5b5	78	10	on	on	IN
cord-344093-3bniy5b5	78	11	the	the	DT
cord-344093-3bniy5b5	78	12	activation	activation	NN
cord-344093-3bniy5b5	78	13	of	of	IN
cord-344093-3bniy5b5	78	14	the	the	DT
cord-344093-3bniy5b5	78	15	same	same	JJ
cord-344093-3bniy5b5	78	16	transcriptional	transcriptional	JJ
cord-344093-3bniy5b5	78	17	activators	activator	NNS
cord-344093-3bniy5b5	78	18	,	,	,
cord-344093-3bniy5b5	78	19	including	include	VBG
cord-344093-3bniy5b5	78	20	IRF3	IRF3	NNP
cord-344093-3bniy5b5	78	21	,	,	,
cord-344093-3bniy5b5	78	22	IRF7	IRF7	NNP
cord-344093-3bniy5b5	78	23	,	,	,
cord-344093-3bniy5b5	78	24	and	and	CC
cord-344093-3bniy5b5	78	25	NFκB.	nfκb.	NN
cord-344093-3bniy5b5	79	1	These	these	DT
cord-344093-3bniy5b5	79	2	observations	observation	NNS
cord-344093-3bniy5b5	79	3	initially	initially	RB
cord-344093-3bniy5b5	79	4	led	lead	VBD
cord-344093-3bniy5b5	79	5	to	to	IN
cord-344093-3bniy5b5	79	6	the	the	DT
cord-344093-3bniy5b5	79	7	conclusion	conclusion	NN
cord-344093-3bniy5b5	79	8	that	that	DT
cord-344093-3bniy5b5	79	9	type	type	NN
cord-344093-3bniy5b5	79	10	I	-PRON-	PRP
cord-344093-3bniy5b5	79	11	and	and	CC
cord-344093-3bniy5b5	80	1	type	type	NN
cord-344093-3bniy5b5	80	2	III	III	NNP
cord-344093-3bniy5b5	80	3	IFN	IFN	NNP
cord-344093-3bniy5b5	80	4	comprised	comprise	VBD
cord-344093-3bniy5b5	80	5	two	two	CD
cord-344093-3bniy5b5	80	6	completely	completely	RB
cord-344093-3bniy5b5	80	7	redundant	redundant	JJ
cord-344093-3bniy5b5	80	8	systems	system	NNS
cord-344093-3bniy5b5	80	9	to	to	TO
cord-344093-3bniy5b5	80	10	induce	induce	VB
cord-344093-3bniy5b5	80	11	ISGs	isg	NNS
cord-344093-3bniy5b5	80	12	in	in	IN
cord-344093-3bniy5b5	80	13	response	response	NN
cord-344093-3bniy5b5	80	14	to	to	IN
cord-344093-3bniy5b5	80	15	PAMP	PAMP	NNP
cord-344093-3bniy5b5	80	16	recognition	recognition	NN
cord-344093-3bniy5b5	80	17	.	.	.
cord-344093-3bniy5b5	81	1	However	however	RB
cord-344093-3bniy5b5	81	2	,	,	,
cord-344093-3bniy5b5	81	3	more	more	JJR
cord-344093-3bniy5b5	81	4	recent	recent	JJ
cord-344093-3bniy5b5	81	5	data	datum	NNS
cord-344093-3bniy5b5	81	6	suggest	suggest	VBP
cord-344093-3bniy5b5	81	7	distinct	distinct	JJ
cord-344093-3bniy5b5	81	8	selection	selection	NN
cord-344093-3bniy5b5	81	9	mechanisms	mechanism	NNS
cord-344093-3bniy5b5	81	10	for	for	IN
cord-344093-3bniy5b5	81	11	either	either	DT
cord-344093-3bniy5b5	81	12	type	type	NN
cord-344093-3bniy5b5	81	13	I	-PRON-	PRP
cord-344093-3bniy5b5	81	14	or	or	CC
cord-344093-3bniy5b5	81	15	type	type	NN
cord-344093-3bniy5b5	81	16	III	III	NNP
cord-344093-3bniy5b5	81	17	IFN	IFN	NNP
cord-344093-3bniy5b5	81	18	expression	expression	NN
cord-344093-3bniy5b5	81	19	.	.	.
cord-344093-3bniy5b5	82	1	As	as	IN
cord-344093-3bniy5b5	82	2	such	such	JJ
cord-344093-3bniy5b5	82	3	,	,	,
cord-344093-3bniy5b5	82	4	IPS-1	IPS-1	NNP
cord-344093-3bniy5b5	82	5	specifically	specifically	RB
cord-344093-3bniy5b5	82	6	induces	induce	VBZ
cord-344093-3bniy5b5	82	7	IFN	IFN	NNP
cord-344093-3bniy5b5	82	8	-	-	HYPH
cord-344093-3bniy5b5	82	9	λ	λ	NNP
cord-344093-3bniy5b5	82	10	,	,	,
cord-344093-3bniy5b5	82	11	but	but	CC
cord-344093-3bniy5b5	82	12	not	not	RB
cord-344093-3bniy5b5	82	13	type	type	VB
cord-344093-3bniy5b5	82	14	I	-PRON-	PRP
cord-344093-3bniy5b5	82	15	IFN	IFN	NNP
cord-344093-3bniy5b5	82	16	,	,	,
cord-344093-3bniy5b5	82	17	when	when	WRB
cord-344093-3bniy5b5	82	18	located	locate	VBN
cord-344093-3bniy5b5	82	19	at	at	IN
cord-344093-3bniy5b5	82	20	the	the	DT
cord-344093-3bniy5b5	82	21	peroxisomal	peroxisomal	JJ
cord-344093-3bniy5b5	82	22	membrane	membrane	NN
cord-344093-3bniy5b5	82	23	instead	instead	RB
cord-344093-3bniy5b5	82	24	of	of	IN
cord-344093-3bniy5b5	82	25	the	the	DT
cord-344093-3bniy5b5	82	26	mitochondrial	mitochondrial	JJ
cord-344093-3bniy5b5	82	27	membrane	membrane	NN
cord-344093-3bniy5b5	82	28	in	in	IN
cord-344093-3bniy5b5	82	29	response	response	NN
cord-344093-3bniy5b5	82	30	to	to	IN
cord-344093-3bniy5b5	82	31	RIG	rig	NN
cord-344093-3bniy5b5	82	32	-	-	:
cord-344093-3bniy5b5	82	33	I	-PRON-	PRP
cord-344093-3bniy5b5	82	34	activation	activation	NN
cord-344093-3bniy5b5	82	35	by	by	IN
cord-344093-3bniy5b5	82	36	reovirus	reovirus	NNP
cord-344093-3bniy5b5	82	37	,	,	,
cord-344093-3bniy5b5	82	38	Sendai	Sendai	NNP
cord-344093-3bniy5b5	82	39	virus	virus	NN
cord-344093-3bniy5b5	82	40	,	,	,
cord-344093-3bniy5b5	82	41	or	or	CC
cord-344093-3bniy5b5	82	42	dengue	dengue	NN
cord-344093-3bniy5b5	82	43	virus	virus	NN
cord-344093-3bniy5b5	82	44	challenge	challenge	NN
cord-344093-3bniy5b5	82	45	(	(	-LRB-
cord-344093-3bniy5b5	82	46	43	43	CD
cord-344093-3bniy5b5	82	47	)	)	-RRB-
cord-344093-3bniy5b5	82	48	.	.	.
cord-344093-3bniy5b5	83	1	Interestingly	interestingly	RB
cord-344093-3bniy5b5	83	2	,	,	,
cord-344093-3bniy5b5	83	3	type	type	NN
cord-344093-3bniy5b5	83	4	III	III	NNP
cord-344093-3bniy5b5	83	5	IFN	IFN	NNP
cord-344093-3bniy5b5	83	6	induction	induction	NN
cord-344093-3bniy5b5	83	7	is	be	VBZ
cord-344093-3bniy5b5	83	8	largely	largely	RB
cord-344093-3bniy5b5	83	9	independent	independent	JJ
cord-344093-3bniy5b5	83	10	toward	toward	IN
cord-344093-3bniy5b5	83	11	AP-1	AP-1	NNP
cord-344093-3bniy5b5	83	12	translocation	translocation	NN
cord-344093-3bniy5b5	83	13	,	,	,
cord-344093-3bniy5b5	83	14	which	which	WDT
cord-344093-3bniy5b5	83	15	facilitates	facilitate	VBZ
cord-344093-3bniy5b5	83	16	an	an	DT
cord-344093-3bniy5b5	83	17	instantaneous	instantaneous	JJ
cord-344093-3bniy5b5	83	18	induction	induction	NN
cord-344093-3bniy5b5	83	19	of	of	IN
cord-344093-3bniy5b5	83	20	IFN	IFN	NNP
cord-344093-3bniy5b5	83	21	-	-	HYPH
cord-344093-3bniy5b5	83	22	λ	λ	NNP
cord-344093-3bniy5b5	83	23	after	after	IN
cord-344093-3bniy5b5	83	24	viral	viral	JJ
cord-344093-3bniy5b5	83	25	recognition	recognition	NN
cord-344093-3bniy5b5	83	26	,	,	,
cord-344093-3bniy5b5	83	27	highlighting	highlight	VBG
cord-344093-3bniy5b5	83	28	it	-PRON-	PRP
cord-344093-3bniy5b5	83	29	as	as	IN
cord-344093-3bniy5b5	83	30	an	an	DT
cord-344093-3bniy5b5	83	31	important	important	JJ
cord-344093-3bniy5b5	83	32	immediate	immediate	JJ
cord-344093-3bniy5b5	83	33	factor	factor	NN
cord-344093-3bniy5b5	83	34	driving	drive	VBG
cord-344093-3bniy5b5	83	35	innate	innate	JJ
cord-344093-3bniy5b5	83	36	microbial	microbial	JJ
cord-344093-3bniy5b5	83	37	defense	defense	NN
cord-344093-3bniy5b5	83	38	mechanisms	mechanism	NNS
cord-344093-3bniy5b5	83	39	.	.	.
cord-344093-3bniy5b5	84	1	Release	Release	NNP
cord-344093-3bniy5b5	84	2	of	of	IN
cord-344093-3bniy5b5	84	3	IFNs	ifn	NNS
cord-344093-3bniy5b5	84	4	upon	upon	IN
cord-344093-3bniy5b5	84	5	pathogen	pathogen	NN
cord-344093-3bniy5b5	84	6	recognition	recognition	NN
cord-344093-3bniy5b5	84	7	is	be	VBZ
cord-344093-3bniy5b5	84	8	a	a	DT
cord-344093-3bniy5b5	84	9	highly	highly	RB
cord-344093-3bniy5b5	84	10	conserved	conserve	VBN
cord-344093-3bniy5b5	84	11	mechanism	mechanism	NN
cord-344093-3bniy5b5	84	12	-	-	HYPH
cord-344093-3bniy5b5	84	13	found	find	VBN
cord-344093-3bniy5b5	84	14	from	from	IN
cord-344093-3bniy5b5	84	15	teleost	teleost	JJ
cord-344093-3bniy5b5	84	16	fish	fish	NN
cord-344093-3bniy5b5	84	17	to	to	IN
cord-344093-3bniy5b5	84	18	insects	insect	NNS
cord-344093-3bniy5b5	84	19	and	and	CC
cord-344093-3bniy5b5	84	20	mammals	mammal	NNS
cord-344093-3bniy5b5	84	21	-	-	,
cord-344093-3bniy5b5	84	22	to	to	TO
cord-344093-3bniy5b5	84	23	prepare	prepare	VB
cord-344093-3bniy5b5	84	24	the	the	DT
cord-344093-3bniy5b5	84	25	surrounding	surround	VBG
cord-344093-3bniy5b5	84	26	cells	cell	NNS
cord-344093-3bniy5b5	84	27	as	as	RB
cord-344093-3bniy5b5	84	28	well	well	RB
cord-344093-3bniy5b5	84	29	as	as	IN
cord-344093-3bniy5b5	84	30	the	the	DT
cord-344093-3bniy5b5	84	31	host	host	NN
cord-344093-3bniy5b5	84	32	defense	defense	NN
cord-344093-3bniy5b5	84	33	against	against	IN
cord-344093-3bniy5b5	84	34	the	the	DT
cord-344093-3bniy5b5	84	35	invading	invade	VBG
cord-344093-3bniy5b5	84	36	threat	threat	NN
cord-344093-3bniy5b5	84	37	(	(	-LRB-
cord-344093-3bniy5b5	84	38	44	44	CD
cord-344093-3bniy5b5	84	39	,	,	,
cord-344093-3bniy5b5	84	40	45	45	CD
cord-344093-3bniy5b5	84	41	)	)	-RRB-
cord-344093-3bniy5b5	84	42	.	.	.
cord-344093-3bniy5b5	85	1	Whereas	whereas	IN
cord-344093-3bniy5b5	85	2	often	often	RB
cord-344093-3bniy5b5	85	3	high	high	JJ
cord-344093-3bniy5b5	85	4	-	-	HYPH
cord-344093-3bniy5b5	85	5	level	level	NN
cord-344093-3bniy5b5	85	6	IFN	IFN	NNP
cord-344093-3bniy5b5	85	7	production	production	NN
cord-344093-3bniy5b5	85	8	relies	rely	VBZ
cord-344093-3bniy5b5	85	9	on	on	IN
cord-344093-3bniy5b5	85	10	specialized	specialized	JJ
cord-344093-3bniy5b5	85	11	sentinel	sentinel	NN
cord-344093-3bniy5b5	85	12	cells	cell	NNS
cord-344093-3bniy5b5	85	13	such	such	JJ
cord-344093-3bniy5b5	85	14	as	as	IN
cord-344093-3bniy5b5	85	15	macrophages	macrophage	NNS
cord-344093-3bniy5b5	85	16	or	or	CC
cord-344093-3bniy5b5	85	17	dendritic	dendritic	JJ
cord-344093-3bniy5b5	85	18	cells	cell	NNS
cord-344093-3bniy5b5	85	19	(	(	-LRB-
cord-344093-3bniy5b5	85	20	DCs	DCs	NNP
cord-344093-3bniy5b5	85	21	)	)	-RRB-
cord-344093-3bniy5b5	85	22	,	,	,
cord-344093-3bniy5b5	85	23	mostly	mostly	RB
cord-344093-3bniy5b5	85	24	all	all	DT
cord-344093-3bniy5b5	85	25	cells	cell	NNS
cord-344093-3bniy5b5	85	26	of	of	IN
cord-344093-3bniy5b5	85	27	the	the	DT
cord-344093-3bniy5b5	85	28	multicellular	multicellular	JJ
cord-344093-3bniy5b5	85	29	organisms	organism	NNS
cord-344093-3bniy5b5	85	30	are	be	VBP
cord-344093-3bniy5b5	85	31	able	able	JJ
cord-344093-3bniy5b5	85	32	to	to	TO
cord-344093-3bniy5b5	85	33	respond	respond	VB
cord-344093-3bniy5b5	85	34	to	to	IN
cord-344093-3bniy5b5	85	35	at	at	RB
cord-344093-3bniy5b5	85	36	least	least	RBS
cord-344093-3bniy5b5	85	37	one	one	CD
cord-344093-3bniy5b5	85	38	type	type	NN
cord-344093-3bniy5b5	85	39	of	of	IN
cord-344093-3bniy5b5	85	40	IFN	IFN	NNP
cord-344093-3bniy5b5	85	41	by	by	IN
cord-344093-3bniy5b5	85	42	expression	expression	NN
cord-344093-3bniy5b5	85	43	of	of	IN
cord-344093-3bniy5b5	85	44	respective	respective	JJ
cord-344093-3bniy5b5	85	45	receptors	receptor	NNS
cord-344093-3bniy5b5	85	46	.	.	.
cord-344093-3bniy5b5	86	1	Receptor	receptor	NN
cord-344093-3bniy5b5	86	2	binding	binding	NN
cord-344093-3bniy5b5	86	3	then	then	RB
cord-344093-3bniy5b5	86	4	induces	induce	VBZ
cord-344093-3bniy5b5	86	5	a	a	DT
cord-344093-3bniy5b5	86	6	signal	signal	NN
cord-344093-3bniy5b5	86	7	transduction	transduction	NN
cord-344093-3bniy5b5	86	8	cascade	cascade	NN
cord-344093-3bniy5b5	86	9	relying	rely	VBG
cord-344093-3bniy5b5	86	10	on	on	IN
cord-344093-3bniy5b5	86	11	the	the	DT
cord-344093-3bniy5b5	86	12	Janus	Janus	NNP
cord-344093-3bniy5b5	86	13	kinase	kinase	NN
cord-344093-3bniy5b5	86	14	(	(	-LRB-
cord-344093-3bniy5b5	86	15	JAK	JAK	NNP
cord-344093-3bniy5b5	86	16	)	)	-RRB-
cord-344093-3bniy5b5	86	17	and	and	CC
cord-344093-3bniy5b5	86	18	Signal	Signal	NNP
cord-344093-3bniy5b5	86	19	Transducer	Transducer	NNP
cord-344093-3bniy5b5	86	20	and	and	CC
cord-344093-3bniy5b5	86	21	Activator	Activator	NNP
cord-344093-3bniy5b5	86	22	of	of	IN
cord-344093-3bniy5b5	86	23	Transcription	Transcription	NNP
cord-344093-3bniy5b5	86	24	(	(	-LRB-
cord-344093-3bniy5b5	86	25	STAT	STAT	NNP
cord-344093-3bniy5b5	86	26	)	)	-RRB-
cord-344093-3bniy5b5	86	27	,	,	,
cord-344093-3bniy5b5	86	28	which	which	WDT
cord-344093-3bniy5b5	86	29	results	result	VBZ
cord-344093-3bniy5b5	86	30	in	in	IN
cord-344093-3bniy5b5	86	31	efficient	efficient	JJ
cord-344093-3bniy5b5	86	32	transcription	transcription	NN
cord-344093-3bniy5b5	86	33	of	of	IN
cord-344093-3bniy5b5	86	34	a	a	DT
cord-344093-3bniy5b5	86	35	plethora	plethora	NN
cord-344093-3bniy5b5	86	36	of	of	IN
cord-344093-3bniy5b5	86	37	different	different	JJ
cord-344093-3bniy5b5	86	38	ISGs	isg	NNS
cord-344093-3bniy5b5	86	39	in	in	IN
cord-344093-3bniy5b5	86	40	infected	infect	VBN
cord-344093-3bniy5b5	86	41	as	as	RB
cord-344093-3bniy5b5	86	42	well	well	RB
cord-344093-3bniy5b5	86	43	as	as	IN
cord-344093-3bniy5b5	86	44	bystander	bystander	NN
cord-344093-3bniy5b5	86	45	cells	cell	NNS
cord-344093-3bniy5b5	86	46	(	(	-LRB-
cord-344093-3bniy5b5	86	47	46	46	CD
cord-344093-3bniy5b5	86	48	,	,	,
cord-344093-3bniy5b5	86	49	47	47	CD
cord-344093-3bniy5b5	86	50	)	)	-RRB-
cord-344093-3bniy5b5	86	51	.	.	.
cord-344093-3bniy5b5	87	1	IFNs	ifn	NNS
cord-344093-3bniy5b5	87	2	engage	engage	VB
cord-344093-3bniy5b5	87	3	a	a	DT
cord-344093-3bniy5b5	87	4	classical	classical	JJ
cord-344093-3bniy5b5	87	5	canonical	canonical	JJ
cord-344093-3bniy5b5	87	6	signal	signal	NN
cord-344093-3bniy5b5	87	7	transduction	transduction	NN
cord-344093-3bniy5b5	87	8	cascade	cascade	NN
cord-344093-3bniy5b5	87	9	employing	employ	VBG
cord-344093-3bniy5b5	87	10	JAK	JAK	NNP
cord-344093-3bniy5b5	87	11	/	/	SYM
cord-344093-3bniy5b5	87	12	STAT	stat	NN
cord-344093-3bniy5b5	87	13	molecules	molecule	NNS
cord-344093-3bniy5b5	87	14	after	after	IN
cord-344093-3bniy5b5	87	15	binding	bind	VBG
cord-344093-3bniy5b5	87	16	to	to	IN
cord-344093-3bniy5b5	87	17	their	-PRON-	PRP$
cord-344093-3bniy5b5	87	18	respective	respective	JJ
cord-344093-3bniy5b5	87	19	receptors	receptor	NNS
cord-344093-3bniy5b5	87	20	.	.	.
cord-344093-3bniy5b5	88	1	Herein	herein	RB
cord-344093-3bniy5b5	88	2	,	,	,
cord-344093-3bniy5b5	88	3	type	type	NN
cord-344093-3bniy5b5	88	4	I	-PRON-	PRP
cord-344093-3bniy5b5	88	5	IFNs	ifns	VBP
cord-344093-3bniy5b5	88	6	ligate	ligate	VB
cord-344093-3bniy5b5	88	7	to	to	IN
cord-344093-3bniy5b5	88	8	their	-PRON-	PRP$
cord-344093-3bniy5b5	88	9	common	common	JJ
cord-344093-3bniy5b5	88	10	heterodimeric	heterodimeric	JJ
cord-344093-3bniy5b5	88	11	receptor	receptor	NN
cord-344093-3bniy5b5	88	12	consisting	consist	VBG
cord-344093-3bniy5b5	88	13	of	of	IN
cord-344093-3bniy5b5	88	14	the	the	DT
cord-344093-3bniy5b5	88	15	IFN	IFN	NNP
cord-344093-3bniy5b5	88	16	-	-	HYPH
cord-344093-3bniy5b5	88	17	α	α	NNP
cord-344093-3bniy5b5	88	18	receptor	receptor	NN
cord-344093-3bniy5b5	88	19	(	(	-LRB-
cord-344093-3bniy5b5	88	20	IFNAR)1	ifnar)1	NN
cord-344093-3bniy5b5	88	21	and	and	CC
cord-344093-3bniy5b5	88	22	IFNAR2	ifnar2	NN
cord-344093-3bniy5b5	88	23	subunits	subunit	NNS
cord-344093-3bniy5b5	88	24	,	,	,
cord-344093-3bniy5b5	88	25	whereas	whereas	IN
cord-344093-3bniy5b5	88	26	type	type	NN
cord-344093-3bniy5b5	88	27	III	III	NNP
cord-344093-3bniy5b5	88	28	IFNs	IFNs	NNP
cord-344093-3bniy5b5	88	29	act	act	NN
cord-344093-3bniy5b5	88	30	via	via	IN
cord-344093-3bniy5b5	88	31	a	a	DT
cord-344093-3bniy5b5	88	32	interleukin-10	interleukin-10	NN
cord-344093-3bniy5b5	88	33	receptor	receptor	NN
cord-344093-3bniy5b5	88	34	2	2	CD
cord-344093-3bniy5b5	88	35	(	(	-LRB-
cord-344093-3bniy5b5	88	36	IL-10R2)/IFN	IL-10R2)/IFN	NNP
cord-344093-3bniy5b5	88	37	-	-	HYPH
cord-344093-3bniy5b5	88	38	λ	λ	NNP
cord-344093-3bniy5b5	88	39	receptor	receptor	NN
cord-344093-3bniy5b5	88	40	1	1	CD
cord-344093-3bniy5b5	88	41	(	(	-LRB-
cord-344093-3bniy5b5	88	42	IFNLR1	ifnlr1	RB
cord-344093-3bniy5b5	88	43	)	)	-RRB-
cord-344093-3bniy5b5	88	44	heterodimer	heterodimer	NN
cord-344093-3bniy5b5	88	45	that	that	IN
cord-344093-3bniy5b5	88	46	to	to	IN
cord-344093-3bniy5b5	88	47	date	date	NN
cord-344093-3bniy5b5	88	48	has	have	VBZ
cord-344093-3bniy5b5	88	49	been	be	VBN
cord-344093-3bniy5b5	88	50	reported	report	VBN
cord-344093-3bniy5b5	88	51	to	to	TO
cord-344093-3bniy5b5	88	52	be	be	VB
cord-344093-3bniy5b5	88	53	restricted	restrict	VBN
cord-344093-3bniy5b5	88	54	in	in	IN
cord-344093-3bniy5b5	88	55	its	-PRON-	PRP$
cord-344093-3bniy5b5	88	56	expression	expression	NN
cord-344093-3bniy5b5	88	57	to	to	IN
cord-344093-3bniy5b5	88	58	epithelial	epithelial	JJ
cord-344093-3bniy5b5	88	59	cells	cell	NNS
cord-344093-3bniy5b5	88	60	(	(	-LRB-
cord-344093-3bniy5b5	88	61	48	48	CD
cord-344093-3bniy5b5	88	62	)	)	-RRB-
cord-344093-3bniy5b5	88	63	.	.	.
cord-344093-3bniy5b5	89	1	In	in	IN
cord-344093-3bniy5b5	89	2	type	type	NN
cord-344093-3bniy5b5	89	3	I	-PRON-	PRP
cord-344093-3bniy5b5	89	4	IFN	IFN	NNP
cord-344093-3bniy5b5	89	5	signaling	signal	VBG
cord-344093-3bniy5b5	89	6	,	,	,
cord-344093-3bniy5b5	89	7	IFNAR	IFNAR	NNP
cord-344093-3bniy5b5	89	8	engagement	engagement	NN
cord-344093-3bniy5b5	89	9	leads	lead	VBZ
cord-344093-3bniy5b5	89	10	to	to	IN
cord-344093-3bniy5b5	89	11	the	the	DT
cord-344093-3bniy5b5	89	12	activation	activation	NN
cord-344093-3bniy5b5	89	13	of	of	IN
cord-344093-3bniy5b5	89	14	the	the	DT
cord-344093-3bniy5b5	89	15	receptor	receptor	NN
cord-344093-3bniy5b5	89	16	-	-	HYPH
cord-344093-3bniy5b5	89	17	associated	associate	VBN
cord-344093-3bniy5b5	89	18	protein	protein	NN
cord-344093-3bniy5b5	89	19	tyrosine	tyrosine	NN
cord-344093-3bniy5b5	89	20	kinases	kinase	NNS
cord-344093-3bniy5b5	89	21	JAK1	JAK1	NNP
cord-344093-3bniy5b5	89	22	and	and	CC
cord-344093-3bniy5b5	89	23	tyrosine	tyrosine	NN
cord-344093-3bniy5b5	89	24	kinase	kinase	VBN
cord-344093-3bniy5b5	89	25	2	2	CD
cord-344093-3bniy5b5	89	26	followed	follow	VBD
cord-344093-3bniy5b5	89	27	by	by	IN
cord-344093-3bniy5b5	89	28	the	the	DT
cord-344093-3bniy5b5	89	29	recruitment	recruitment	NN
cord-344093-3bniy5b5	89	30	or	or	CC
cord-344093-3bniy5b5	89	31	repositioning	repositioning	NN
cord-344093-3bniy5b5	89	32	of	of	IN
cord-344093-3bniy5b5	89	33	already	already	RB
cord-344093-3bniy5b5	89	34	associated	associate	VBN
cord-344093-3bniy5b5	89	35	but	but	CC
cord-344093-3bniy5b5	89	36	elsewise	elsewise	RB
cord-344093-3bniy5b5	89	37	latent	latent	JJ
cord-344093-3bniy5b5	89	38	cytoplasmatic	cytoplasmatic	JJ
cord-344093-3bniy5b5	89	39	transcription	transcription	NN
cord-344093-3bniy5b5	89	40	factors	factor	NNS
cord-344093-3bniy5b5	89	41	STAT1	stat1	VBP
cord-344093-3bniy5b5	89	42	and	and	CC
cord-344093-3bniy5b5	89	43	STAT2	STAT2	NNS
cord-344093-3bniy5b5	89	44	.	.	.
cord-344093-3bniy5b5	90	1	Consequently	consequently	RB
cord-344093-3bniy5b5	90	2	,	,	,
cord-344093-3bniy5b5	90	3	STAT1	stat1	NN
cord-344093-3bniy5b5	90	4	/	/	SYM
cord-344093-3bniy5b5	90	5	STAT2	STAT2	NNS
cord-344093-3bniy5b5	90	6	are	be	VBP
cord-344093-3bniy5b5	90	7	phosphorylated	phosphorylate	VBN
cord-344093-3bniy5b5	90	8	on	on	IN
cord-344093-3bniy5b5	90	9	conserved	conserve	VBN
cord-344093-3bniy5b5	90	10	tyrosine	tyrosine	NN
cord-344093-3bniy5b5	90	11	residues	residue	NNS
cord-344093-3bniy5b5	90	12	,	,	,
cord-344093-3bniy5b5	90	13	they	-PRON-	PRP
cord-344093-3bniy5b5	90	14	disassemble	disassemble	VBP
cord-344093-3bniy5b5	90	15	,	,	,
cord-344093-3bniy5b5	90	16	undergo	undergo	VB
cord-344093-3bniy5b5	90	17	conformational	conformational	JJ
cord-344093-3bniy5b5	90	18	changes	change	NNS
cord-344093-3bniy5b5	90	19	enabling	enable	VBG
cord-344093-3bniy5b5	90	20	their	-PRON-	PRP$
cord-344093-3bniy5b5	90	21	heterodimerization	heterodimerization	NN
cord-344093-3bniy5b5	90	22	as	as	RB
cord-344093-3bniy5b5	90	23	well	well	RB
cord-344093-3bniy5b5	90	24	as	as	IN
cord-344093-3bniy5b5	90	25	the	the	DT
cord-344093-3bniy5b5	90	26	exposure	exposure	NN
cord-344093-3bniy5b5	90	27	of	of	IN
cord-344093-3bniy5b5	90	28	a	a	DT
cord-344093-3bniy5b5	90	29	nuclear	nuclear	JJ
cord-344093-3bniy5b5	90	30	localization	localization	NN
cord-344093-3bniy5b5	90	31	sequence	sequence	NN
cord-344093-3bniy5b5	90	32	.	.	.
cord-344093-3bniy5b5	91	1	Subsequently	subsequently	RB
cord-344093-3bniy5b5	91	2	,	,	,
cord-344093-3bniy5b5	91	3	the	the	DT
cord-344093-3bniy5b5	91	4	STAT1	stat1	NN
cord-344093-3bniy5b5	91	5	/	/	SYM
cord-344093-3bniy5b5	91	6	STAT2	STAT2	NNS
cord-344093-3bniy5b5	91	7	heterodimer	heterodimer	NN
cord-344093-3bniy5b5	91	8	translocates	translocate	NNS
cord-344093-3bniy5b5	91	9	into	into	IN
cord-344093-3bniy5b5	91	10	the	the	DT
cord-344093-3bniy5b5	91	11	nucleus	nucleus	NN
cord-344093-3bniy5b5	91	12	where	where	WRB
cord-344093-3bniy5b5	91	13	it	-PRON-	PRP
cord-344093-3bniy5b5	91	14	interacts	interact	VBZ
cord-344093-3bniy5b5	91	15	with	with	IN
cord-344093-3bniy5b5	91	16	the	the	DT
cord-344093-3bniy5b5	91	17	IRF9	IRF9	NNP
cord-344093-3bniy5b5	91	18	to	to	TO
cord-344093-3bniy5b5	91	19	form	form	VB
cord-344093-3bniy5b5	91	20	the	the	DT
cord-344093-3bniy5b5	91	21	trimeric	trimeric	NNP
cord-344093-3bniy5b5	91	22	IFN	IFN	NNP
cord-344093-3bniy5b5	91	23	-	-	HYPH
cord-344093-3bniy5b5	91	24	stimulated	stimulate	VBN
cord-344093-3bniy5b5	91	25	factor	factor	NN
cord-344093-3bniy5b5	91	26	3	3	CD
cord-344093-3bniy5b5	91	27	(	(	-LRB-
cord-344093-3bniy5b5	91	28	ISGF3	isgf3	NN
cord-344093-3bniy5b5	91	29	)	)	-RRB-
cord-344093-3bniy5b5	91	30	.	.	.
cord-344093-3bniy5b5	92	1	ISGF3	ISGF3	NNP
cord-344093-3bniy5b5	92	2	binds	bind	VBZ
cord-344093-3bniy5b5	92	3	cognate	cognate	JJ
cord-344093-3bniy5b5	92	4	DNA	dna	NN
cord-344093-3bniy5b5	92	5	sequences	sequence	NNS
cord-344093-3bniy5b5	92	6	,	,	,
cord-344093-3bniy5b5	92	7	the	the	DT
cord-344093-3bniy5b5	92	8	IFN	IFN	NNP
cord-344093-3bniy5b5	92	9	-	-	HYPH
cord-344093-3bniy5b5	92	10	stimulated	stimulate	VBN
cord-344093-3bniy5b5	92	11	response	response	NN
cord-344093-3bniy5b5	92	12	elements	element	NNS
cord-344093-3bniy5b5	92	13	(	(	-LRB-
cord-344093-3bniy5b5	92	14	ISRE	ISRE	NNP
cord-344093-3bniy5b5	92	15	)	)	-RRB-
cord-344093-3bniy5b5	92	16	,	,	,
cord-344093-3bniy5b5	92	17	finally	finally	RB
cord-344093-3bniy5b5	92	18	leading	lead	VBG
cord-344093-3bniy5b5	92	19	to	to	IN
cord-344093-3bniy5b5	92	20	ISG	ISG	NNP
cord-344093-3bniy5b5	92	21	induction	induction	NN
cord-344093-3bniy5b5	92	22	.	.	.
cord-344093-3bniy5b5	93	1	Also	also	RB
cord-344093-3bniy5b5	93	2	type	type	NN
cord-344093-3bniy5b5	93	3	III	III	NNP
cord-344093-3bniy5b5	93	4	IFN	IFN	NNP
cord-344093-3bniy5b5	93	5	interaction	interaction	NN
cord-344093-3bniy5b5	93	6	with	with	IN
cord-344093-3bniy5b5	93	7	the	the	DT
cord-344093-3bniy5b5	93	8	IL-10R2	IL-10R2	NNP
cord-344093-3bniy5b5	93	9	/	/	SYM
cord-344093-3bniy5b5	93	10	IFNLR1	ifnlr1	NN
cord-344093-3bniy5b5	93	11	receptor	receptor	NN
cord-344093-3bniy5b5	93	12	complex	complex	JJ
cord-344093-3bniy5b5	93	13	triggers	trigger	VBZ
cord-344093-3bniy5b5	93	14	STAT1	stat1	XX
cord-344093-3bniy5b5	93	15	/	/	SYM
cord-344093-3bniy5b5	93	16	STAT2	STAT2	NNS
cord-344093-3bniy5b5	93	17	heterodimerization	heterodimerization	NN
cord-344093-3bniy5b5	93	18	,	,	,
cord-344093-3bniy5b5	93	19	nuclear	nuclear	JJ
cord-344093-3bniy5b5	93	20	translocation	translocation	NN
cord-344093-3bniy5b5	93	21	,	,	,
cord-344093-3bniy5b5	93	22	and	and	CC
cord-344093-3bniy5b5	93	23	ISGF3	ISGF3	NNP
cord-344093-3bniy5b5	93	24	assembly	assembly	NN
cord-344093-3bniy5b5	93	25	(	(	-LRB-
cord-344093-3bniy5b5	93	26	49	49	CD
cord-344093-3bniy5b5	93	27	)	)	-RRB-
cord-344093-3bniy5b5	93	28	.	.	.
cord-344093-3bniy5b5	94	1	Interferon	interferon	NN
cord-344093-3bniy5b5	94	2	signaling	signal	VBG
cord-344093-3bniy5b5	94	3	results	result	NNS
cord-344093-3bniy5b5	94	4	in	in	IN
cord-344093-3bniy5b5	94	5	the	the	DT
cord-344093-3bniy5b5	94	6	induction	induction	NN
cord-344093-3bniy5b5	94	7	of	of	IN
cord-344093-3bniy5b5	94	8	ISGs	ISGs	NNPS
cord-344093-3bniy5b5	94	9	evoking	evoke	VBG
cord-344093-3bniy5b5	94	10	different	different	JJ
cord-344093-3bniy5b5	94	11	cellular	cellular	JJ
cord-344093-3bniy5b5	94	12	responses	response	NNS
cord-344093-3bniy5b5	94	13	against	against	IN
cord-344093-3bniy5b5	94	14	viral	viral	JJ
cord-344093-3bniy5b5	94	15	infection	infection	NN
cord-344093-3bniy5b5	94	16	,	,	,
cord-344093-3bniy5b5	94	17	both	both	CC
cord-344093-3bniy5b5	94	18	in	in	IN
cord-344093-3bniy5b5	94	19	infected	infect	VBN
cord-344093-3bniy5b5	94	20	as	as	RB
cord-344093-3bniy5b5	94	21	well	well	RB
cord-344093-3bniy5b5	94	22	as	as	IN
cord-344093-3bniy5b5	94	23	in	in	IN
cord-344093-3bniy5b5	94	24	non	non	JJ
cord-344093-3bniy5b5	94	25	-	-	JJ
cord-344093-3bniy5b5	94	26	infected	infected	JJ
cord-344093-3bniy5b5	94	27	cells	cell	NNS
cord-344093-3bniy5b5	94	28	,	,	,
cord-344093-3bniy5b5	94	29	including	include	VBG
cord-344093-3bniy5b5	94	30	direct	direct	JJ
cord-344093-3bniy5b5	94	31	antiviral	antiviral	JJ
cord-344093-3bniy5b5	94	32	,	,	,
cord-344093-3bniy5b5	94	33	immune	immune	JJ
cord-344093-3bniy5b5	94	34	-	-	HYPH
cord-344093-3bniy5b5	94	35	modulatory	modulatory	JJ
cord-344093-3bniy5b5	94	36	,	,	,
cord-344093-3bniy5b5	94	37	or	or	CC
cord-344093-3bniy5b5	94	38	cell	cell	NN
cord-344093-3bniy5b5	94	39	death	death	NN
cord-344093-3bniy5b5	94	40	-	-	HYPH
cord-344093-3bniy5b5	94	41	inducing	induce	VBG
cord-344093-3bniy5b5	94	42	effects	effect	NNS
cord-344093-3bniy5b5	94	43	to	to	TO
cord-344093-3bniy5b5	94	44	enable	enable	VB
cord-344093-3bniy5b5	94	45	an	an	DT
cord-344093-3bniy5b5	94	46	immediate	immediate	JJ
cord-344093-3bniy5b5	94	47	and	and	CC
cord-344093-3bniy5b5	94	48	robust	robust	JJ
cord-344093-3bniy5b5	94	49	response	response	NN
cord-344093-3bniy5b5	94	50	to	to	IN
cord-344093-3bniy5b5	94	51	a	a	DT
cord-344093-3bniy5b5	94	52	pathogen	pathogen	NN
cord-344093-3bniy5b5	94	53	challenge	challenge	NN
cord-344093-3bniy5b5	94	54	.	.	.
cord-344093-3bniy5b5	95	1	Many	many	JJ
cord-344093-3bniy5b5	95	2	ISGs	isg	NNS
cord-344093-3bniy5b5	95	3	directly	directly	RB
cord-344093-3bniy5b5	95	4	interfere	interfere	VB
cord-344093-3bniy5b5	95	5	with	with	IN
cord-344093-3bniy5b5	95	6	viral	viral	JJ
cord-344093-3bniy5b5	95	7	replication	replication	NN
cord-344093-3bniy5b5	95	8	on	on	IN
cord-344093-3bniy5b5	95	9	an	an	DT
cord-344093-3bniy5b5	95	10	intracellular	intracellular	JJ
cord-344093-3bniy5b5	95	11	level	level	NN
cord-344093-3bniy5b5	95	12	.	.	.
cord-344093-3bniy5b5	96	1	Well	well	RB
cord-344093-3bniy5b5	96	2	-	-	HYPH
cord-344093-3bniy5b5	96	3	studied	study	VBN
cord-344093-3bniy5b5	96	4	examples	example	NNS
cord-344093-3bniy5b5	96	5	of	of	IN
cord-344093-3bniy5b5	96	6	antiviral	antiviral	JJ
cord-344093-3bniy5b5	96	7	ISGs	isg	NNS
cord-344093-3bniy5b5	96	8	comprise	comprise	VBP
cord-344093-3bniy5b5	96	9	IFN	IFN	NNP
cord-344093-3bniy5b5	96	10	-	-	HYPH
cord-344093-3bniy5b5	96	11	induced	induce	VBN
cord-344093-3bniy5b5	96	12	transmembrane	transmembrane	NN
cord-344093-3bniy5b5	96	13	proteins	protein	NNS
cord-344093-3bniy5b5	96	14	(	(	-LRB-
cord-344093-3bniy5b5	96	15	IFITMs	ifitm	NNS
cord-344093-3bniy5b5	96	16	)	)	-RRB-
cord-344093-3bniy5b5	96	17	effective	effective	JJ
cord-344093-3bniy5b5	96	18	in	in	IN
cord-344093-3bniy5b5	96	19	IAV	IAV	NNP
cord-344093-3bniy5b5	96	20	,	,	,
cord-344093-3bniy5b5	96	21	West	West	NNP
cord-344093-3bniy5b5	96	22	Nile	Nile	NNP
cord-344093-3bniy5b5	96	23	virus	virus	NN
cord-344093-3bniy5b5	96	24	,	,	,
cord-344093-3bniy5b5	96	25	and	and	CC
cord-344093-3bniy5b5	97	1	dengue	dengue	NN
cord-344093-3bniy5b5	97	2	virus	virus	NN
cord-344093-3bniy5b5	97	3	infection	infection	NN
cord-344093-3bniy5b5	97	4	(	(	-LRB-
cord-344093-3bniy5b5	97	5	50	50	CD
cord-344093-3bniy5b5	97	6	,	,	,
cord-344093-3bniy5b5	97	7	51	51	CD
cord-344093-3bniy5b5	97	8	)	)	-RRB-
cord-344093-3bniy5b5	97	9	,	,	,
cord-344093-3bniy5b5	97	10	the	the	DT
cord-344093-3bniy5b5	97	11	myxovirus	myxovirus	NNP
cord-344093-3bniy5b5	97	12	resistance	resistance	NN
cord-344093-3bniy5b5	97	13	protein	protein	NN
cord-344093-3bniy5b5	97	14	A	A	NNP
cord-344093-3bniy5b5	97	15	(	(	-LRB-
cord-344093-3bniy5b5	97	16	MxA	mxa	NN
cord-344093-3bniy5b5	97	17	)	)	-RRB-
cord-344093-3bniy5b5	97	18	that	that	WDT
cord-344093-3bniy5b5	97	19	interferes	interfere	VBZ
cord-344093-3bniy5b5	97	20	with	with	IN
cord-344093-3bniy5b5	97	21	VSV	VSV	NNP
cord-344093-3bniy5b5	97	22	mRNA	mRNA	NNP
cord-344093-3bniy5b5	97	23	production	production	NN
cord-344093-3bniy5b5	97	24	and	and	CC
cord-344093-3bniy5b5	97	25	binds	bind	VBZ
cord-344093-3bniy5b5	97	26	the	the	DT
cord-344093-3bniy5b5	97	27	IAV	IAV	NNP
cord-344093-3bniy5b5	97	28	nucleocapsid	nucleocapsid	NN
cord-344093-3bniy5b5	97	29	to	to	TO
cord-344093-3bniy5b5	97	30	prevent	prevent	VB
cord-344093-3bniy5b5	97	31	nuclear	nuclear	JJ
cord-344093-3bniy5b5	97	32	translocation	translocation	NN
cord-344093-3bniy5b5	97	33	of	of	IN
cord-344093-3bniy5b5	97	34	viral	viral	JJ
cord-344093-3bniy5b5	97	35	genetic	genetic	JJ
cord-344093-3bniy5b5	97	36	material	material	NN
cord-344093-3bniy5b5	97	37	(	(	-LRB-
cord-344093-3bniy5b5	97	38	52	52	CD
cord-344093-3bniy5b5	97	39	)	)	-RRB-
cord-344093-3bniy5b5	97	40	(	(	-LRB-
cord-344093-3bniy5b5	97	41	53	53	CD
cord-344093-3bniy5b5	97	42	)	)	-RRB-
cord-344093-3bniy5b5	97	43	(	(	-LRB-
cord-344093-3bniy5b5	97	44	54	54	CD
cord-344093-3bniy5b5	97	45	)	)	-RRB-
cord-344093-3bniy5b5	97	46	,	,	,
cord-344093-3bniy5b5	97	47	the	the	DT
cord-344093-3bniy5b5	97	48	2	2	CD
cord-344093-3bniy5b5	97	49	-	-	SYM
cord-344093-3bniy5b5	97	50	5-oligoadenylate	5-oligoadenylate	CD
cord-344093-3bniy5b5	97	51	synthase	synthase	NN
cord-344093-3bniy5b5	97	52	(	(	-LRB-
cord-344093-3bniy5b5	97	53	OAS	OAS	NNP
cord-344093-3bniy5b5	97	54	)	)	-RRB-
cord-344093-3bniy5b5	97	55	,	,	,
cord-344093-3bniy5b5	97	56	which	which	WDT
cord-344093-3bniy5b5	97	57	activates	activate	VBZ
cord-344093-3bniy5b5	97	58	RNAse	RNAse	NNP
cord-344093-3bniy5b5	97	59	L	l	NN
cord-344093-3bniy5b5	97	60	triggering	trigger	VBG
cord-344093-3bniy5b5	97	61	viral	viral	JJ
cord-344093-3bniy5b5	97	62	RNA	RNA	NNP
cord-344093-3bniy5b5	97	63	degradation	degradation	NN
cord-344093-3bniy5b5	97	64	,	,	,
cord-344093-3bniy5b5	97	65	or	or	CC
cord-344093-3bniy5b5	97	66	the	the	DT
cord-344093-3bniy5b5	97	67	PRR	PRR	NNP
cord-344093-3bniy5b5	97	68	PKR	PKR	NNP
cord-344093-3bniy5b5	97	69	,	,	,
cord-344093-3bniy5b5	97	70	which	which	WDT
cord-344093-3bniy5b5	97	71	besides	besides	IN
cord-344093-3bniy5b5	97	72	activating	activate	VBG
cord-344093-3bniy5b5	97	73	the	the	DT
cord-344093-3bniy5b5	97	74	IFN	IFN	NNP
cord-344093-3bniy5b5	97	75	response	response	NN
cord-344093-3bniy5b5	97	76	has	have	VBZ
cord-344093-3bniy5b5	97	77	a	a	DT
cord-344093-3bniy5b5	97	78	major	major	JJ
cord-344093-3bniy5b5	97	79	impact	impact	NN
cord-344093-3bniy5b5	97	80	on	on	IN
cord-344093-3bniy5b5	97	81	viral	viral	JJ
cord-344093-3bniy5b5	97	82	protein	protein	NN
cord-344093-3bniy5b5	97	83	translation	translation	NN
cord-344093-3bniy5b5	97	84	by	by	IN
cord-344093-3bniy5b5	97	85	inhibiting	inhibit	VBG
cord-344093-3bniy5b5	97	86	the	the	DT
cord-344093-3bniy5b5	97	87	eIF2α	eif2α	JJ
cord-344093-3bniy5b5	97	88	(	(	-LRB-
cord-344093-3bniy5b5	97	89	55	55	CD
cord-344093-3bniy5b5	97	90	)	)	-RRB-
cord-344093-3bniy5b5	97	91	.	.	.
cord-344093-3bniy5b5	98	1	More	more	RBR
cord-344093-3bniy5b5	98	2	recently	recently	RB
cord-344093-3bniy5b5	98	3	identified	identify	VBN
cord-344093-3bniy5b5	98	4	ISGs	isg	NNS
cord-344093-3bniy5b5	98	5	include	include	VBP
cord-344093-3bniy5b5	98	6	the	the	DT
cord-344093-3bniy5b5	98	7	plasminogen	plasminogen	NN
cord-344093-3bniy5b5	98	8	activator	activator	NN
cord-344093-3bniy5b5	98	9	inhibitor	inhibitor	NN
cord-344093-3bniy5b5	98	10	1	1	CD
cord-344093-3bniy5b5	98	11	that	that	WDT
cord-344093-3bniy5b5	98	12	blocks	block	VBZ
cord-344093-3bniy5b5	98	13	IAV	IAV	NNP
cord-344093-3bniy5b5	98	14	infection	infection	NN
cord-344093-3bniy5b5	98	15	by	by	IN
cord-344093-3bniy5b5	98	16	inhibiting	inhibit	VBG
cord-344093-3bniy5b5	98	17	glycoprotein	glycoprotein	NN
cord-344093-3bniy5b5	98	18	cleavage	cleavage	NN
cord-344093-3bniy5b5	98	19	executed	execute	VBN
cord-344093-3bniy5b5	98	20	by	by	IN
cord-344093-3bniy5b5	98	21	extracellular	extracellular	JJ
cord-344093-3bniy5b5	98	22	airway	airway	NN
cord-344093-3bniy5b5	98	23	proteases	protease	NNS
cord-344093-3bniy5b5	98	24	(	(	-LRB-
cord-344093-3bniy5b5	98	25	56	56	CD
cord-344093-3bniy5b5	98	26	)	)	-RRB-
cord-344093-3bniy5b5	98	27	or	or	CC
cord-344093-3bniy5b5	98	28	the	the	DT
cord-344093-3bniy5b5	98	29	antiviral	antiviral	JJ
cord-344093-3bniy5b5	98	30	ISG20	isg20	NN
cord-344093-3bniy5b5	98	31	that	that	WDT
cord-344093-3bniy5b5	98	32	limits	limit	VBZ
cord-344093-3bniy5b5	98	33	IAV	IAV	NNP
cord-344093-3bniy5b5	98	34	viral	viral	JJ
cord-344093-3bniy5b5	98	35	replication	replication	NN
cord-344093-3bniy5b5	98	36	via	via	IN
cord-344093-3bniy5b5	98	37	its	-PRON-	PRP$
cord-344093-3bniy5b5	98	38	exonuclease	exonuclease	NN
cord-344093-3bniy5b5	98	39	activity	activity	NN
cord-344093-3bniy5b5	98	40	most	most	RBS
cord-344093-3bniy5b5	98	41	likely	likely	JJ
cord-344093-3bniy5b5	98	42	by	by	IN
cord-344093-3bniy5b5	98	43	interfering	interfere	VBG
cord-344093-3bniy5b5	98	44	with	with	IN
cord-344093-3bniy5b5	98	45	the	the	DT
cord-344093-3bniy5b5	98	46	viral	viral	JJ
cord-344093-3bniy5b5	98	47	NP	NP	NNP
cord-344093-3bniy5b5	98	48	(	(	-LRB-
cord-344093-3bniy5b5	98	49	57	57	CD
cord-344093-3bniy5b5	98	50	)	)	-RRB-
cord-344093-3bniy5b5	98	51	.	.	.
cord-344093-3bniy5b5	99	1	Accordingly	accordingly	RB
cord-344093-3bniy5b5	99	2	,	,	,
cord-344093-3bniy5b5	99	3	IFN	IFN	NNP
cord-344093-3bniy5b5	99	4	pretreatment	pretreatment	NN
cord-344093-3bniy5b5	99	5	usually	usually	RB
cord-344093-3bniy5b5	99	6	results	result	VBZ
cord-344093-3bniy5b5	99	7	in	in	IN
cord-344093-3bniy5b5	99	8	the	the	DT
cord-344093-3bniy5b5	99	9	establishment	establishment	NN
cord-344093-3bniy5b5	99	10	of	of	IN
cord-344093-3bniy5b5	99	11	an	an	DT
cord-344093-3bniy5b5	99	12	antiviral	antiviral	JJ
cord-344093-3bniy5b5	99	13	state	state	NN
cord-344093-3bniy5b5	99	14	that	that	WDT
cord-344093-3bniy5b5	99	15	limits	limit	VBZ
cord-344093-3bniy5b5	99	16	viral	viral	JJ
cord-344093-3bniy5b5	99	17	replication	replication	NN
cord-344093-3bniy5b5	99	18	and	and	CC
cord-344093-3bniy5b5	99	19	spread	spread	VBD
cord-344093-3bniy5b5	99	20	from	from	IN
cord-344093-3bniy5b5	99	21	the	the	DT
cord-344093-3bniy5b5	99	22	start	start	NN
cord-344093-3bniy5b5	99	23	of	of	IN
cord-344093-3bniy5b5	99	24	infection	infection	NN
cord-344093-3bniy5b5	99	25	and	and	CC
cord-344093-3bniy5b5	99	26	thus	thus	RB
cord-344093-3bniy5b5	99	27	favors	favor	VBZ
cord-344093-3bniy5b5	99	28	milder	mild	JJR
cord-344093-3bniy5b5	99	29	disease	disease	NN
cord-344093-3bniy5b5	99	30	outcomes	outcome	NNS
cord-344093-3bniy5b5	99	31	.	.	.
cord-344093-3bniy5b5	100	1	IFN	IFN	NNP
cord-344093-3bniy5b5	100	2	-	-	HYPH
cord-344093-3bniy5b5	100	3	α	α	NNP
cord-344093-3bniy5b5	100	4	pretreatment	pretreatment	NN
cord-344093-3bniy5b5	100	5	has	have	VBZ
cord-344093-3bniy5b5	100	6	been	be	VBN
cord-344093-3bniy5b5	100	7	demonstrated	demonstrate	VBN
cord-344093-3bniy5b5	100	8	to	to	TO
cord-344093-3bniy5b5	100	9	limit	limit	VB
cord-344093-3bniy5b5	100	10	viral	viral	JJ
cord-344093-3bniy5b5	100	11	spreading	spreading	NN
cord-344093-3bniy5b5	100	12	of	of	IN
cord-344093-3bniy5b5	100	13	seasonal	seasonal	JJ
cord-344093-3bniy5b5	100	14	IAV	iav	NN
cord-344093-3bniy5b5	100	15	strains	strain	NNS
cord-344093-3bniy5b5	100	16	and	and	CC
cord-344093-3bniy5b5	100	17	thus	thus	RB
cord-344093-3bniy5b5	100	18	decrease	decrease	VB
cord-344093-3bniy5b5	100	19	morbidity	morbidity	NN
cord-344093-3bniy5b5	100	20	and	and	CC
cord-344093-3bniy5b5	100	21	mortality	mortality	NN
cord-344093-3bniy5b5	100	22	in	in	IN
cord-344093-3bniy5b5	100	23	mice	mouse	NNS
cord-344093-3bniy5b5	100	24	,	,	,
cord-344093-3bniy5b5	100	25	guinea	guinea	NN
cord-344093-3bniy5b5	100	26	pigs	pig	NNS
cord-344093-3bniy5b5	100	27	as	as	RB
cord-344093-3bniy5b5	100	28	well	well	RB
cord-344093-3bniy5b5	100	29	as	as	IN
cord-344093-3bniy5b5	100	30	ferrets	ferret	NNS
cord-344093-3bniy5b5	100	31	(	(	-LRB-
cord-344093-3bniy5b5	100	32	58	58	CD
cord-344093-3bniy5b5	100	33	)	)	-RRB-
cord-344093-3bniy5b5	100	34	(	(	-LRB-
cord-344093-3bniy5b5	100	35	59	59	CD
cord-344093-3bniy5b5	100	36	)	)	-RRB-
cord-344093-3bniy5b5	100	37	(	(	-LRB-
cord-344093-3bniy5b5	100	38	60	60	CD
cord-344093-3bniy5b5	100	39	)	)	-RRB-
cord-344093-3bniy5b5	100	40	.	.	.
cord-344093-3bniy5b5	101	1	As	as	IN
cord-344093-3bniy5b5	101	2	shown	show	VBN
cord-344093-3bniy5b5	101	3	by	by	IN
cord-344093-3bniy5b5	101	4	a	a	DT
cord-344093-3bniy5b5	101	5	study	study	NN
cord-344093-3bniy5b5	101	6	by	by	IN
cord-344093-3bniy5b5	101	7	Tumpey	Tumpey	NNP
cord-344093-3bniy5b5	101	8	et	et	NNP
cord-344093-3bniy5b5	101	9	al	al	NNP
cord-344093-3bniy5b5	101	10	.	.	.
cord-344093-3bniy5b5	102	1	(	(	-LRB-
cord-344093-3bniy5b5	102	2	61	61	CD
cord-344093-3bniy5b5	102	3	)	)	-RRB-
cord-344093-3bniy5b5	102	4	,	,	,
cord-344093-3bniy5b5	102	5	this	this	DT
cord-344093-3bniy5b5	102	6	effect	effect	NN
cord-344093-3bniy5b5	102	7	can	can	MD
cord-344093-3bniy5b5	102	8	be	be	VB
cord-344093-3bniy5b5	102	9	attributed	attribute	VBN
cord-344093-3bniy5b5	102	10	to	to	IN
cord-344093-3bniy5b5	102	11	the	the	DT
cord-344093-3bniy5b5	102	12	early	early	JJ
cord-344093-3bniy5b5	102	13	induction	induction	NN
cord-344093-3bniy5b5	102	14	of	of	IN
cord-344093-3bniy5b5	102	15	antiviral	antiviral	JJ
cord-344093-3bniy5b5	102	16	ISGs	ISGs	NNPS
cord-344093-3bniy5b5	102	17	including	include	VBG
cord-344093-3bniy5b5	102	18	MxA.	MxA.	NNP
cord-344093-3bniy5b5	103	1	Importantly	importantly	RB
cord-344093-3bniy5b5	103	2	,	,	,
cord-344093-3bniy5b5	103	3	type	type	NN
cord-344093-3bniy5b5	103	4	I	-PRON-	PRP
cord-344093-3bniy5b5	103	5	IFN	IFN	NNP
cord-344093-3bniy5b5	103	6	pretreatment	pretreatment	NN
cord-344093-3bniy5b5	103	7	also	also	RB
cord-344093-3bniy5b5	103	8	dampens	dampen	VBZ
cord-344093-3bniy5b5	103	9	early	early	JJ
cord-344093-3bniy5b5	103	10	replication	replication	NN
cord-344093-3bniy5b5	103	11	of	of	IN
cord-344093-3bniy5b5	103	12	highly	highly	RB
cord-344093-3bniy5b5	103	13	pathogenic	pathogenic	JJ
cord-344093-3bniy5b5	103	14	avian	avian	JJ
cord-344093-3bniy5b5	103	15	influenza	influenza	NN
cord-344093-3bniy5b5	103	16	in	in	IN
cord-344093-3bniy5b5	103	17	ferrets	ferret	NNS
cord-344093-3bniy5b5	103	18	(	(	-LRB-
cord-344093-3bniy5b5	103	19	58	58	CD
cord-344093-3bniy5b5	103	20	)	)	-RRB-
cord-344093-3bniy5b5	103	21	.	.	.
cord-344093-3bniy5b5	104	1	Also	also	RB
cord-344093-3bniy5b5	104	2	in	in	IN
cord-344093-3bniy5b5	104	3	respiratory	respiratory	JJ
cord-344093-3bniy5b5	104	4	syncytial	syncytial	JJ
cord-344093-3bniy5b5	104	5	virus	virus	NN
cord-344093-3bniy5b5	104	6	(	(	-LRB-
cord-344093-3bniy5b5	104	7	RSV	RSV	NNP
cord-344093-3bniy5b5	104	8	)	)	-RRB-
cord-344093-3bniy5b5	104	9	infection	infection	NN
cord-344093-3bniy5b5	104	10	,	,	,
cord-344093-3bniy5b5	104	11	treatment	treatment	NN
cord-344093-3bniy5b5	104	12	with	with	IN
cord-344093-3bniy5b5	104	13	recombinant	recombinant	JJ
cord-344093-3bniy5b5	104	14	IFN	IFN	NNP
cord-344093-3bniy5b5	104	15	-	-	HYPH
cord-344093-3bniy5b5	104	16	α	α	NN
cord-344093-3bniy5b5	104	17	results	result	NNS
cord-344093-3bniy5b5	104	18	in	in	IN
cord-344093-3bniy5b5	104	19	significantly	significantly	RB
cord-344093-3bniy5b5	104	20	decreased	decrease	VBD
cord-344093-3bniy5b5	104	21	lung	lung	NN
cord-344093-3bniy5b5	104	22	viral	viral	JJ
cord-344093-3bniy5b5	104	23	titers	titer	NNS
cord-344093-3bniy5b5	104	24	,	,	,
cord-344093-3bniy5b5	104	25	alveolar	alveolar	JJ
cord-344093-3bniy5b5	104	26	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	104	27	cell	cell	NN
cord-344093-3bniy5b5	104	28	accumulation	accumulation	NN
cord-344093-3bniy5b5	104	29	,	,	,
cord-344093-3bniy5b5	104	30	and	and	CC
cord-344093-3bniy5b5	104	31	clinical	clinical	JJ
cord-344093-3bniy5b5	104	32	disease	disease	NN
cord-344093-3bniy5b5	104	33	in	in	IN
cord-344093-3bniy5b5	104	34	RSV	RSV	NNP
cord-344093-3bniy5b5	104	35	-	-	HYPH
cord-344093-3bniy5b5	104	36	infected	infect	VBN
cord-344093-3bniy5b5	104	37	mice	mouse	NNS
cord-344093-3bniy5b5	104	38	(	(	-LRB-
cord-344093-3bniy5b5	104	39	62	62	CD
cord-344093-3bniy5b5	104	40	)	)	-RRB-
cord-344093-3bniy5b5	104	41	.	.	.
cord-344093-3bniy5b5	105	1	In	in	IN
cord-344093-3bniy5b5	105	2	addition	addition	NN
cord-344093-3bniy5b5	105	3	,	,	,
cord-344093-3bniy5b5	105	4	respiratory	respiratory	JJ
cord-344093-3bniy5b5	105	5	infections	infection	NNS
cord-344093-3bniy5b5	105	6	caused	cause	VBN
cord-344093-3bniy5b5	105	7	by	by	IN
cord-344093-3bniy5b5	105	8	emerging	emerge	VBG
cord-344093-3bniy5b5	105	9	coronaviruses	coronaviruse	NNS
cord-344093-3bniy5b5	105	10	(	(	-LRB-
cord-344093-3bniy5b5	105	11	CoV	CoV	NNP
cord-344093-3bniy5b5	105	12	)	)	-RRB-
cord-344093-3bniy5b5	105	13	can	can	MD
cord-344093-3bniy5b5	105	14	be	be	VB
cord-344093-3bniy5b5	105	15	ameliorated	ameliorate	VBN
cord-344093-3bniy5b5	105	16	by	by	IN
cord-344093-3bniy5b5	105	17	type	type	NN
cord-344093-3bniy5b5	105	18	I	-PRON-	PRP
cord-344093-3bniy5b5	105	19	IFN	IFN	NNP
cord-344093-3bniy5b5	105	20	pretreatment	pretreatment	NN
cord-344093-3bniy5b5	105	21	strategies	strategy	NNS
cord-344093-3bniy5b5	105	22	.	.	.
cord-344093-3bniy5b5	106	1	In	in	IN
cord-344093-3bniy5b5	106	2	an	an	DT
cord-344093-3bniy5b5	106	3	in	in	IN
cord-344093-3bniy5b5	106	4	vivo	vivo	NN
cord-344093-3bniy5b5	106	5	macaque	macaque	NN
cord-344093-3bniy5b5	106	6	model	model	NN
cord-344093-3bniy5b5	106	7	(	(	-LRB-
cord-344093-3bniy5b5	106	8	Macaca	Macaca	NNP
cord-344093-3bniy5b5	106	9	fascicularis	fascicularis	NN
cord-344093-3bniy5b5	106	10	)	)	-RRB-
cord-344093-3bniy5b5	106	11	of	of	IN
cord-344093-3bniy5b5	106	12	severe	severe	JJ
cord-344093-3bniy5b5	106	13	acute	acute	JJ
cord-344093-3bniy5b5	106	14	respiratory	respiratory	JJ
cord-344093-3bniy5b5	106	15	syndrome	syndrome	NN
cord-344093-3bniy5b5	106	16	(	(	-LRB-
cord-344093-3bniy5b5	106	17	SARS)-CoV	SARS)-CoV	NNP
cord-344093-3bniy5b5	106	18	infection	infection	NN
cord-344093-3bniy5b5	106	19	,	,	,
cord-344093-3bniy5b5	106	20	it	-PRON-	PRP
cord-344093-3bniy5b5	106	21	could	could	MD
cord-344093-3bniy5b5	106	22	be	be	VB
cord-344093-3bniy5b5	106	23	demonstrated	demonstrate	VBN
cord-344093-3bniy5b5	106	24	that	that	IN
cord-344093-3bniy5b5	106	25	pretreatment	pretreatment	NN
cord-344093-3bniy5b5	106	26	with	with	IN
cord-344093-3bniy5b5	106	27	pegylated	pegylated	JJ
cord-344093-3bniy5b5	106	28	IFN	IFN	NNP
cord-344093-3bniy5b5	106	29	-	-	HYPH
cord-344093-3bniy5b5	106	30	α	α	NNP
cord-344093-3bniy5b5	106	31	significantly	significantly	RB
cord-344093-3bniy5b5	106	32	diminished	diminish	VBD
cord-344093-3bniy5b5	106	33	CoV	cov	NN
cord-344093-3bniy5b5	106	34	replication	replication	NN
cord-344093-3bniy5b5	106	35	and	and	CC
cord-344093-3bniy5b5	106	36	excretion	excretion	NN
cord-344093-3bniy5b5	106	37	and	and	CC
cord-344093-3bniy5b5	106	38	resulted	result	VBD
cord-344093-3bniy5b5	106	39	in	in	IN
cord-344093-3bniy5b5	106	40	reduced	reduce	VBN
cord-344093-3bniy5b5	106	41	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	106	42	damage	damage	NN
cord-344093-3bniy5b5	106	43	(	(	-LRB-
cord-344093-3bniy5b5	106	44	63	63	CD
cord-344093-3bniy5b5	106	45	)	)	-RRB-
cord-344093-3bniy5b5	106	46	.	.	.
cord-344093-3bniy5b5	107	1	Macaques	macaque	NNS
cord-344093-3bniy5b5	107	2	also	also	RB
cord-344093-3bniy5b5	107	3	serve	serve	VBP
cord-344093-3bniy5b5	107	4	as	as	IN
cord-344093-3bniy5b5	107	5	a	a	DT
cord-344093-3bniy5b5	107	6	preclinical	preclinical	JJ
cord-344093-3bniy5b5	107	7	model	model	NN
cord-344093-3bniy5b5	107	8	for	for	IN
cord-344093-3bniy5b5	107	9	Middle	Middle	NNP
cord-344093-3bniy5b5	107	10	East	East	NNP
cord-344093-3bniy5b5	107	11	respiratory	respiratory	JJ
cord-344093-3bniy5b5	107	12	syndrome	syndrome	NN
cord-344093-3bniy5b5	107	13	(	(	-LRB-
cord-344093-3bniy5b5	107	14	MERS)-CoV	MERS)-CoV	NNP
cord-344093-3bniy5b5	107	15	,	,	,
cord-344093-3bniy5b5	107	16	and	and	CC
cord-344093-3bniy5b5	107	17	similar	similar	JJ
cord-344093-3bniy5b5	107	18	to	to	IN
cord-344093-3bniy5b5	107	19	SARS	SARS	NNP
cord-344093-3bniy5b5	107	20	-	-	HYPH
cord-344093-3bniy5b5	107	21	CoV	CoV	NNP
cord-344093-3bniy5b5	107	22	,	,	,
cord-344093-3bniy5b5	107	23	IFN	IFN	NNP
cord-344093-3bniy5b5	107	24	-	-	HYPH
cord-344093-3bniy5b5	107	25	α	α	NNP
cord-344093-3bniy5b5	107	26	in	in	IN
cord-344093-3bniy5b5	107	27	combination	combination	NN
cord-344093-3bniy5b5	107	28	therapy	therapy	NN
cord-344093-3bniy5b5	107	29	with	with	IN
cord-344093-3bniy5b5	107	30	ribavirin	ribavirin	NN
cord-344093-3bniy5b5	107	31	reduces	reduce	VBZ
cord-344093-3bniy5b5	107	32	viral	viral	JJ
cord-344093-3bniy5b5	107	33	replication	replication	NN
cord-344093-3bniy5b5	107	34	and	and	CC
cord-344093-3bniy5b5	107	35	severe	severe	JJ
cord-344093-3bniy5b5	107	36	histopathological	histopathological	JJ
cord-344093-3bniy5b5	107	37	changes	change	NNS
cord-344093-3bniy5b5	107	38	(	(	-LRB-
cord-344093-3bniy5b5	107	39	64	64	CD
cord-344093-3bniy5b5	107	40	)	)	-RRB-
cord-344093-3bniy5b5	107	41	.	.	.
cord-344093-3bniy5b5	108	1	In	in	IN
cord-344093-3bniy5b5	108	2	line	line	NN
cord-344093-3bniy5b5	108	3	,	,	,
cord-344093-3bniy5b5	108	4	genetic	genetic	JJ
cord-344093-3bniy5b5	108	5	alteration	alteration	NN
cord-344093-3bniy5b5	108	6	leading	lead	VBG
cord-344093-3bniy5b5	108	7	to	to	IN
cord-344093-3bniy5b5	108	8	an	an	DT
cord-344093-3bniy5b5	108	9	enhanced	enhanced	JJ
cord-344093-3bniy5b5	108	10	type	type	NN
cord-344093-3bniy5b5	108	11	I	-PRON-	PRP
cord-344093-3bniy5b5	108	12	IFN	IFN	NNP
cord-344093-3bniy5b5	108	13	signaling	signaling	NN
cord-344093-3bniy5b5	108	14	has	have	VBZ
cord-344093-3bniy5b5	108	15	been	be	VBN
cord-344093-3bniy5b5	108	16	demonstrated	demonstrate	VBN
cord-344093-3bniy5b5	108	17	to	to	TO
cord-344093-3bniy5b5	108	18	limit	limit	VB
cord-344093-3bniy5b5	108	19	IAV	IAV	NNP
cord-344093-3bniy5b5	108	20	-	-	HYPH
cord-344093-3bniy5b5	108	21	induced	induce	VBN
cord-344093-3bniy5b5	108	22	disease	disease	NN
cord-344093-3bniy5b5	108	23	outcomes	outcome	NNS
cord-344093-3bniy5b5	108	24	,	,	,
cord-344093-3bniy5b5	108	25	as	as	IN
cord-344093-3bniy5b5	108	26	a	a	DT
cord-344093-3bniy5b5	108	27	recent	recent	JJ
cord-344093-3bniy5b5	108	28	study	study	NN
cord-344093-3bniy5b5	108	29	by	by	IN
cord-344093-3bniy5b5	108	30	Xing	Xing	NNP
cord-344093-3bniy5b5	108	31	et	et	FW
cord-344093-3bniy5b5	108	32	al	al	NNP
cord-344093-3bniy5b5	108	33	.	.	.
cord-344093-3bniy5b5	109	1	(	(	-LRB-
cord-344093-3bniy5b5	109	2	65	65	CD
cord-344093-3bniy5b5	109	3	)	)	-RRB-
cord-344093-3bniy5b5	109	4	reported	report	VBD
cord-344093-3bniy5b5	109	5	that	that	IN
cord-344093-3bniy5b5	109	6	deletion	deletion	NN
cord-344093-3bniy5b5	109	7	of	of	IN
cord-344093-3bniy5b5	109	8	TRIM29	TRIM29	NNP
cord-344093-3bniy5b5	109	9	,	,	,
cord-344093-3bniy5b5	109	10	a	a	DT
cord-344093-3bniy5b5	109	11	negative	negative	JJ
cord-344093-3bniy5b5	109	12	regulator	regulator	NN
cord-344093-3bniy5b5	109	13	of	of	IN
cord-344093-3bniy5b5	109	14	NEMO	NEMO	NNP
cord-344093-3bniy5b5	109	15	,	,	,
cord-344093-3bniy5b5	109	16	which	which	WDT
cord-344093-3bniy5b5	109	17	leads	lead	VBZ
cord-344093-3bniy5b5	109	18	to	to	IN
cord-344093-3bniy5b5	109	19	NFκB	nfκb	JJ
cord-344093-3bniy5b5	109	20	induction	induction	NN
cord-344093-3bniy5b5	109	21	and	and	CC
cord-344093-3bniy5b5	109	22	therefore	therefore	RB
cord-344093-3bniy5b5	109	23	enhanced	enhanced	JJ
cord-344093-3bniy5b5	109	24	type	type	NN
cord-344093-3bniy5b5	110	1	I	-PRON-	PRP
cord-344093-3bniy5b5	110	2	IFN	IFN	NNP
cord-344093-3bniy5b5	110	3	production	production	NN
cord-344093-3bniy5b5	110	4	,	,	,
cord-344093-3bniy5b5	110	5	is	be	VBZ
cord-344093-3bniy5b5	110	6	protective	protective	JJ
cord-344093-3bniy5b5	110	7	in	in	IN
cord-344093-3bniy5b5	110	8	vivo	vivo	NN
cord-344093-3bniy5b5	110	9	in	in	IN
cord-344093-3bniy5b5	110	10	IAV	IAV	NNP
cord-344093-3bniy5b5	110	11	-	-	HYPH
cord-344093-3bniy5b5	110	12	infected	infect	VBN
cord-344093-3bniy5b5	110	13	mice	mouse	NNS
cord-344093-3bniy5b5	110	14	.	.	.
cord-344093-3bniy5b5	111	1	Conversely	conversely	RB
cord-344093-3bniy5b5	111	2	,	,	,
cord-344093-3bniy5b5	111	3	the	the	DT
cord-344093-3bniy5b5	111	4	genetic	genetic	JJ
cord-344093-3bniy5b5	111	5	depletion	depletion	NN
cord-344093-3bniy5b5	111	6	of	of	IN
cord-344093-3bniy5b5	111	7	IFN	IFN	NNP
cord-344093-3bniy5b5	111	8	signaling	signal	VBG
cord-344093-3bniy5b5	111	9	in	in	IN
cord-344093-3bniy5b5	111	10	IFN	IFN	NNP
cord-344093-3bniy5b5	111	11	receptor	receptor	NN
cord-344093-3bniy5b5	111	12	-	-	HYPH
cord-344093-3bniy5b5	111	13	deficient	deficient	JJ
cord-344093-3bniy5b5	111	14	mice	mouse	NNS
cord-344093-3bniy5b5	111	15	can	can	MD
cord-344093-3bniy5b5	111	16	result	result	VB
cord-344093-3bniy5b5	111	17	in	in	IN
cord-344093-3bniy5b5	111	18	a	a	DT
cord-344093-3bniy5b5	111	19	lack	lack	NN
cord-344093-3bniy5b5	111	20	of	of	IN
cord-344093-3bniy5b5	111	21	viral	viral	JJ
cord-344093-3bniy5b5	111	22	control	control	NN
cord-344093-3bniy5b5	111	23	,	,	,
cord-344093-3bniy5b5	111	24	resulting	result	VBG
cord-344093-3bniy5b5	111	25	in	in	IN
cord-344093-3bniy5b5	111	26	enhanced	enhance	VBN
cord-344093-3bniy5b5	111	27	viral	viral	JJ
cord-344093-3bniy5b5	111	28	titers	titer	NNS
cord-344093-3bniy5b5	111	29	in	in	IN
cord-344093-3bniy5b5	111	30	different	different	JJ
cord-344093-3bniy5b5	111	31	viral	viral	JJ
cord-344093-3bniy5b5	111	32	infections	infection	NNS
cord-344093-3bniy5b5	111	33	including	include	VBG
cord-344093-3bniy5b5	111	34	RSV	RSV	NNP
cord-344093-3bniy5b5	111	35	or	or	CC
cord-344093-3bniy5b5	111	36	IAV	IAV	NNP
cord-344093-3bniy5b5	111	37	(	(	-LRB-
cord-344093-3bniy5b5	111	38	66	66	CD
cord-344093-3bniy5b5	111	39	,	,	,
cord-344093-3bniy5b5	111	40	67	67	CD
cord-344093-3bniy5b5	111	41	)	)	-RRB-
cord-344093-3bniy5b5	111	42	.	.	.
cord-344093-3bniy5b5	112	1	Still	still	RB
cord-344093-3bniy5b5	112	2	,	,	,
cord-344093-3bniy5b5	112	3	it	-PRON-	PRP
cord-344093-3bniy5b5	112	4	must	must	MD
cord-344093-3bniy5b5	112	5	be	be	VB
cord-344093-3bniy5b5	112	6	noted	note	VBN
cord-344093-3bniy5b5	112	7	that	that	IN
cord-344093-3bniy5b5	112	8	this	this	DT
cord-344093-3bniy5b5	112	9	effect	effect	NN
cord-344093-3bniy5b5	112	10	is	be	VBZ
cord-344093-3bniy5b5	112	11	often	often	RB
cord-344093-3bniy5b5	112	12	mild	mild	JJ
cord-344093-3bniy5b5	112	13	in	in	IN
cord-344093-3bniy5b5	112	14	IFNAR	IFNAR	NNP
cord-344093-3bniy5b5	112	15	-	-	:
cord-344093-3bniy5b5	112	16	or	or	CC
cord-344093-3bniy5b5	112	17	IFNLR	IFNLR	NNP
cord-344093-3bniy5b5	112	18	-	-	HYPH
cord-344093-3bniy5b5	112	19	deficient	deficient	JJ
cord-344093-3bniy5b5	112	20	animals	animal	NNS
cord-344093-3bniy5b5	112	21	,	,	,
cord-344093-3bniy5b5	112	22	which	which	WDT
cord-344093-3bniy5b5	112	23	is	be	VBZ
cord-344093-3bniy5b5	112	24	probably	probably	RB
cord-344093-3bniy5b5	112	25	related	relate	VBN
cord-344093-3bniy5b5	112	26	to	to	IN
cord-344093-3bniy5b5	112	27	a	a	DT
cord-344093-3bniy5b5	112	28	certain	certain	JJ
cord-344093-3bniy5b5	112	29	redundancy	redundancy	NN
cord-344093-3bniy5b5	112	30	between	between	IN
cord-344093-3bniy5b5	112	31	type	type	NN
cord-344093-3bniy5b5	112	32	I	-PRON-	PRP
cord-344093-3bniy5b5	112	33	and	and	CC
cord-344093-3bniy5b5	112	34	type	type	NN
cord-344093-3bniy5b5	112	35	III	III	NNP
cord-344093-3bniy5b5	112	36	IFN	IFN	NNP
cord-344093-3bniy5b5	112	37	signaling	signal	VBG
cord-344093-3bniy5b5	112	38	in	in	IN
cord-344093-3bniy5b5	112	39	limiting	limit	VBG
cord-344093-3bniy5b5	112	40	viral	viral	JJ
cord-344093-3bniy5b5	112	41	spreading	spreading	NN
cord-344093-3bniy5b5	112	42	in	in	IN
cord-344093-3bniy5b5	112	43	epithelial	epithelial	JJ
cord-344093-3bniy5b5	112	44	cells	cell	NNS
cord-344093-3bniy5b5	112	45	(	(	-LRB-
cord-344093-3bniy5b5	112	46	68	68	CD
cord-344093-3bniy5b5	112	47	)	)	-RRB-
cord-344093-3bniy5b5	112	48	.	.	.
cord-344093-3bniy5b5	113	1	In	in	IN
cord-344093-3bniy5b5	113	2	contrast	contrast	NN
cord-344093-3bniy5b5	113	3	,	,	,
cord-344093-3bniy5b5	113	4	IFNAR/	IFNAR/	NNP
cord-344093-3bniy5b5	113	5	IFNLR	IFNLR	NNP
cord-344093-3bniy5b5	113	6	-	-	HYPH
cord-344093-3bniy5b5	113	7	double	double	JJ
cord-344093-3bniy5b5	113	8	knockout	knockout	NN
cord-344093-3bniy5b5	113	9	or	or	CC
cord-344093-3bniy5b5	113	10	STAT1	stat1	VB
cord-344093-3bniy5b5	113	11	knockout	knockout	NN
cord-344093-3bniy5b5	113	12	animals	animal	NNS
cord-344093-3bniy5b5	113	13	that	that	WDT
cord-344093-3bniy5b5	113	14	are	be	VBP
cord-344093-3bniy5b5	113	15	deficient	deficient	JJ
cord-344093-3bniy5b5	113	16	in	in	IN
cord-344093-3bniy5b5	113	17	both	both	DT
cord-344093-3bniy5b5	113	18	type	type	NN
cord-344093-3bniy5b5	113	19	I	-PRON-	PRP
cord-344093-3bniy5b5	113	20	and	and	CC
cord-344093-3bniy5b5	114	1	type	type	NN
cord-344093-3bniy5b5	114	2	III	III	NNP
cord-344093-3bniy5b5	114	3	IFN	IFN	NNP
cord-344093-3bniy5b5	114	4	signal	signal	NN
cord-344093-3bniy5b5	114	5	transduction	transduction	NN
cord-344093-3bniy5b5	114	6	succumb	succumb	VBP
cord-344093-3bniy5b5	114	7	more	more	RBR
cord-344093-3bniy5b5	114	8	readily	readily	RB
cord-344093-3bniy5b5	114	9	to	to	IN
cord-344093-3bniy5b5	114	10	infection	infection	NN
cord-344093-3bniy5b5	114	11	due	due	JJ
cord-344093-3bniy5b5	114	12	to	to	IN
cord-344093-3bniy5b5	114	13	excessive	excessive	JJ
cord-344093-3bniy5b5	114	14	viral	viral	JJ
cord-344093-3bniy5b5	114	15	replication	replication	NN
cord-344093-3bniy5b5	114	16	(	(	-LRB-
cord-344093-3bniy5b5	114	17	69	69	CD
cord-344093-3bniy5b5	114	18	)	)	-RRB-
cord-344093-3bniy5b5	114	19	(	(	-LRB-
cord-344093-3bniy5b5	114	20	70	70	CD
cord-344093-3bniy5b5	114	21	)	)	-RRB-
cord-344093-3bniy5b5	114	22	(	(	-LRB-
cord-344093-3bniy5b5	114	23	71	71	CD
cord-344093-3bniy5b5	114	24	)	)	-RRB-
cord-344093-3bniy5b5	114	25	.	.	.
cord-344093-3bniy5b5	115	1	Vice	Vice	NNP
cord-344093-3bniy5b5	115	2	versa	versa	RB
cord-344093-3bniy5b5	115	3	,	,	,
cord-344093-3bniy5b5	115	4	mutations	mutation	NNS
cord-344093-3bniy5b5	115	5	in	in	IN
cord-344093-3bniy5b5	115	6	key	key	JJ
cord-344093-3bniy5b5	115	7	ISGs	isg	NNS
cord-344093-3bniy5b5	115	8	such	such	JJ
cord-344093-3bniy5b5	115	9	as	as	IN
cord-344093-3bniy5b5	115	10	IFITM3	IFITM3	NNP
cord-344093-3bniy5b5	115	11	are	be	VBP
cord-344093-3bniy5b5	115	12	associated	associate	VBN
cord-344093-3bniy5b5	115	13	with	with	IN
cord-344093-3bniy5b5	115	14	increased	increase	VBN
cord-344093-3bniy5b5	115	15	IAV	IAV	NNP
cord-344093-3bniy5b5	115	16	disease	disease	NN
cord-344093-3bniy5b5	115	17	severity	severity	NN
cord-344093-3bniy5b5	115	18	in	in	IN
cord-344093-3bniy5b5	115	19	mice	mouse	NNS
cord-344093-3bniy5b5	115	20	and	and	CC
cord-344093-3bniy5b5	115	21	humans	human	NNS
cord-344093-3bniy5b5	115	22	(	(	-LRB-
cord-344093-3bniy5b5	115	23	72	72	CD
cord-344093-3bniy5b5	115	24	)	)	-RRB-
cord-344093-3bniy5b5	115	25	.	.	.
cord-344093-3bniy5b5	116	1	However	however	RB
cord-344093-3bniy5b5	116	2	,	,	,
cord-344093-3bniy5b5	116	3	IFN	IFN	NNP
cord-344093-3bniy5b5	116	4	pretreatment	pretreatment	NN
cord-344093-3bniy5b5	116	5	and	and	CC
cord-344093-3bniy5b5	116	6	genetic	genetic	JJ
cord-344093-3bniy5b5	116	7	loss	loss	NN
cord-344093-3bniy5b5	116	8	-	-	HYPH
cord-344093-3bniy5b5	116	9	of	of	IN
cord-344093-3bniy5b5	116	10	-	-	HYPH
cord-344093-3bniy5b5	116	11	function	function	NN
cord-344093-3bniy5b5	116	12	approaches	approach	NNS
cord-344093-3bniy5b5	116	13	generally	generally	RB
cord-344093-3bniy5b5	116	14	are	be	VBP
cord-344093-3bniy5b5	116	15	not	not	RB
cord-344093-3bniy5b5	116	16	relevant	relevant	JJ
cord-344093-3bniy5b5	116	17	to	to	IN
cord-344093-3bniy5b5	116	18	human	human	JJ
cord-344093-3bniy5b5	116	19	respiratory	respiratory	JJ
cord-344093-3bniy5b5	116	20	virus	virus	NN
cord-344093-3bniy5b5	116	21	-	-	HYPH
cord-344093-3bniy5b5	116	22	induced	induce	VBN
cord-344093-3bniy5b5	116	23	hospitalizations	hospitalization	NNS
cord-344093-3bniy5b5	116	24	,	,	,
cord-344093-3bniy5b5	116	25	where	where	WRB
cord-344093-3bniy5b5	116	26	patients	patient	NNS
cord-344093-3bniy5b5	116	27	already	already	RB
cord-344093-3bniy5b5	116	28	present	present	JJ
cord-344093-3bniy5b5	116	29	with	with	IN
cord-344093-3bniy5b5	116	30	ongoing	ongoing	JJ
cord-344093-3bniy5b5	116	31	respiratory	respiratory	JJ
cord-344093-3bniy5b5	116	32	infection	infection	NN
cord-344093-3bniy5b5	116	33	and	and	CC
cord-344093-3bniy5b5	116	34	inflammation	inflammation	NN
cord-344093-3bniy5b5	116	35	,	,	,
cord-344093-3bniy5b5	116	36	and	and	CC
cord-344093-3bniy5b5	116	37	preclinical	preclinical	JJ
cord-344093-3bniy5b5	116	38	studies	study	NNS
cord-344093-3bniy5b5	116	39	underline	underline	VBP
cord-344093-3bniy5b5	116	40	that	that	DT
cord-344093-3bniy5b5	116	41	type	type	NN
cord-344093-3bniy5b5	117	1	I	-PRON-	PRP
cord-344093-3bniy5b5	117	2	IFN	IFN	NNP
cord-344093-3bniy5b5	117	3	signaling	signal	VBG
cord-344093-3bniy5b5	117	4	in	in	IN
cord-344093-3bniy5b5	117	5	an	an	DT
cord-344093-3bniy5b5	117	6	already	already	RB
cord-344093-3bniy5b5	117	7	inflamed	inflamed	JJ
cord-344093-3bniy5b5	117	8	organ	organ	NN
cord-344093-3bniy5b5	117	9	is	be	VBZ
cord-344093-3bniy5b5	117	10	rather	rather	RB
cord-344093-3bniy5b5	117	11	detrimental	detrimental	JJ
cord-344093-3bniy5b5	117	12	and	and	CC
cord-344093-3bniy5b5	117	13	enhances	enhance	VBZ
cord-344093-3bniy5b5	117	14	tissue	tissue	NN
cord-344093-3bniy5b5	117	15	injury	injury	NN
cord-344093-3bniy5b5	117	16	,	,	,
cord-344093-3bniy5b5	117	17	and	and	CC
cord-344093-3bniy5b5	117	18	lack	lack	NN
cord-344093-3bniy5b5	117	19	of	of	IN
cord-344093-3bniy5b5	117	20	type	type	NN
cord-344093-3bniy5b5	118	1	I	-PRON-	PRP
cord-344093-3bniy5b5	118	2	IFN	IFN	NNP
cord-344093-3bniy5b5	118	3	in	in	IN
cord-344093-3bniy5b5	118	4	vivo	vivo	NN
cord-344093-3bniy5b5	118	5	may	may	MD
cord-344093-3bniy5b5	118	6	even	even	RB
cord-344093-3bniy5b5	118	7	ameliorate	ameliorate	VB
cord-344093-3bniy5b5	118	8	disease	disease	NN
cord-344093-3bniy5b5	118	9	outcome	outcome	NN
cord-344093-3bniy5b5	118	10	.	.	.
cord-344093-3bniy5b5	119	1	Accordingly	accordingly	RB
cord-344093-3bniy5b5	119	2	,	,	,
cord-344093-3bniy5b5	119	3	in	in	IN
cord-344093-3bniy5b5	119	4	cases	case	NNS
cord-344093-3bniy5b5	119	5	where	where	WRB
cord-344093-3bniy5b5	119	6	the	the	DT
cord-344093-3bniy5b5	119	7	antiviral	antiviral	JJ
cord-344093-3bniy5b5	119	8	defense	defense	NN
cord-344093-3bniy5b5	119	9	was	be	VBD
cord-344093-3bniy5b5	119	10	not	not	RB
cord-344093-3bniy5b5	119	11	compromised	compromise	VBN
cord-344093-3bniy5b5	119	12	(	(	-LRB-
cord-344093-3bniy5b5	119	13	e.g.	e.g.	RB
cord-344093-3bniy5b5	119	14	,	,	,
cord-344093-3bniy5b5	119	15	in	in	IN
cord-344093-3bniy5b5	119	16	animals	animal	NNS
cord-344093-3bniy5b5	119	17	with	with	IN
cord-344093-3bniy5b5	119	18	efficient	efficient	JJ
cord-344093-3bniy5b5	119	19	type	type	NN
cord-344093-3bniy5b5	119	20	III	iii	NN
cord-344093-3bniy5b5	119	21	IFN	IFN	NNP
cord-344093-3bniy5b5	119	22	signaling	signal	VBG
cord-344093-3bniy5b5	119	23	)	)	-RRB-
cord-344093-3bniy5b5	120	1	IFNAR	IFNAR	NNP
cord-344093-3bniy5b5	120	2	-	-	HYPH
cord-344093-3bniy5b5	120	3	deficient	deficient	JJ
cord-344093-3bniy5b5	120	4	mice	mouse	NNS
cord-344093-3bniy5b5	120	5	infected	infect	VBN
cord-344093-3bniy5b5	120	6	with	with	IN
cord-344093-3bniy5b5	120	7	Sendai	Sendai	NNP
cord-344093-3bniy5b5	120	8	virus	virus	NN
cord-344093-3bniy5b5	120	9	or	or	CC
cord-344093-3bniy5b5	120	10	IAV	IAV	NNP
cord-344093-3bniy5b5	120	11	were	be	VBD
cord-344093-3bniy5b5	120	12	reported	report	VBN
cord-344093-3bniy5b5	120	13	to	to	TO
cord-344093-3bniy5b5	120	14	be	be	VB
cord-344093-3bniy5b5	120	15	more	more	RBR
cord-344093-3bniy5b5	120	16	resistant	resistant	JJ
cord-344093-3bniy5b5	120	17	to	to	IN
cord-344093-3bniy5b5	120	18	infection	infection	NN
cord-344093-3bniy5b5	120	19	-	-	HYPH
cord-344093-3bniy5b5	120	20	induced	induce	VBN
cord-344093-3bniy5b5	120	21	morbidity	morbidity	NN
cord-344093-3bniy5b5	120	22	and	and	CC
cord-344093-3bniy5b5	120	23	mortality	mortality	NN
cord-344093-3bniy5b5	120	24	(	(	-LRB-
cord-344093-3bniy5b5	120	25	73	73	CD
cord-344093-3bniy5b5	120	26	,	,	,
cord-344093-3bniy5b5	120	27	74	74	CD
cord-344093-3bniy5b5	120	28	)	)	-RRB-
cord-344093-3bniy5b5	120	29	.	.	.
cord-344093-3bniy5b5	121	1	Similarly	similarly	RB
cord-344093-3bniy5b5	121	2	,	,	,
cord-344093-3bniy5b5	121	3	in	in	IN
cord-344093-3bniy5b5	121	4	Sendai	Sendai	NNP
cord-344093-3bniy5b5	121	5	virus	virus	NN
cord-344093-3bniy5b5	121	6	in	in	IN
cord-344093-3bniy5b5	121	7	vivo	vivo	NN
cord-344093-3bniy5b5	121	8	infection	infection	NN
cord-344093-3bniy5b5	121	9	,	,	,
cord-344093-3bniy5b5	121	10	Wetzel	Wetzel	NNP
cord-344093-3bniy5b5	121	11	et	et	NNP
cord-344093-3bniy5b5	121	12	al	al	NNP
cord-344093-3bniy5b5	121	13	.	.	.
cord-344093-3bniy5b5	122	1	(	(	-LRB-
cord-344093-3bniy5b5	122	2	75	75	CD
cord-344093-3bniy5b5	122	3	)	)	-RRB-
cord-344093-3bniy5b5	122	4	showed	show	VBD
cord-344093-3bniy5b5	122	5	that	that	IN
cord-344093-3bniy5b5	122	6	increased	increase	VBN
cord-344093-3bniy5b5	122	7	IFN	IFN	NNP
cord-344093-3bniy5b5	122	8	-	-	HYPH
cord-344093-3bniy5b5	122	9	β	β	NNP
cord-344093-3bniy5b5	122	10	levels	level	NNS
cord-344093-3bniy5b5	122	11	in	in	IN
cord-344093-3bniy5b5	122	12	the	the	DT
cord-344093-3bniy5b5	122	13	lung	lung	NN
cord-344093-3bniy5b5	122	14	homogenate	homogenate	NNP
cord-344093-3bniy5b5	122	15	correlates	correlate	VBZ
cord-344093-3bniy5b5	122	16	to	to	IN
cord-344093-3bniy5b5	122	17	increased	increase	VBN
cord-344093-3bniy5b5	122	18	morbidity	morbidity	NN
cord-344093-3bniy5b5	122	19	and	and	CC
cord-344093-3bniy5b5	122	20	mortality	mortality	NN
cord-344093-3bniy5b5	122	21	,	,	,
cord-344093-3bniy5b5	122	22	and	and	CC
cord-344093-3bniy5b5	122	23	also	also	RB
cord-344093-3bniy5b5	122	24	for	for	IN
cord-344093-3bniy5b5	122	25	SARS	SARS	NNP
cord-344093-3bniy5b5	122	26	-	-	HYPH
cord-344093-3bniy5b5	122	27	CoV	CoV	NNP
cord-344093-3bniy5b5	122	28	,	,	,
cord-344093-3bniy5b5	122	29	a	a	DT
cord-344093-3bniy5b5	122	30	recent	recent	JJ
cord-344093-3bniy5b5	122	31	study	study	NN
cord-344093-3bniy5b5	122	32	demonstrates	demonstrate	VBZ
cord-344093-3bniy5b5	122	33	that	that	IN
cord-344093-3bniy5b5	122	34	high	high	JJ
cord-344093-3bniy5b5	122	35	type	type	NN
cord-344093-3bniy5b5	123	1	I	-PRON-	PRP
cord-344093-3bniy5b5	123	2	IFN	IFN	NNP
cord-344093-3bniy5b5	123	3	induction	induction	NN
cord-344093-3bniy5b5	123	4	in	in	IN
cord-344093-3bniy5b5	123	5	an	an	DT
cord-344093-3bniy5b5	123	6	already	already	RB
cord-344093-3bniy5b5	123	7	ongoing	ongoing	JJ
cord-344093-3bniy5b5	123	8	viral	viral	JJ
cord-344093-3bniy5b5	123	9	infection	infection	NN
cord-344093-3bniy5b5	123	10	contributes	contribute	VBZ
cord-344093-3bniy5b5	123	11	to	to	IN
cord-344093-3bniy5b5	123	12	mortality	mortality	NN
cord-344093-3bniy5b5	123	13	in	in	IN
cord-344093-3bniy5b5	123	14	SARS	SARS	NNP
cord-344093-3bniy5b5	123	15	-	-	HYPH
cord-344093-3bniy5b5	123	16	CoV	CoV	NNP
cord-344093-3bniy5b5	123	17	-	-	HYPH
cord-344093-3bniy5b5	123	18	infected	infect	VBN
cord-344093-3bniy5b5	123	19	mice	mouse	NNS
cord-344093-3bniy5b5	123	20	(	(	-LRB-
cord-344093-3bniy5b5	123	21	76	76	CD
cord-344093-3bniy5b5	123	22	)	)	-RRB-
cord-344093-3bniy5b5	123	23	.	.	.
cord-344093-3bniy5b5	124	1	Also	also	RB
cord-344093-3bniy5b5	124	2	for	for	IN
cord-344093-3bniy5b5	124	3	IAV	IAV	NNP
cord-344093-3bniy5b5	124	4	infection	infection	NN
cord-344093-3bniy5b5	124	5	,	,	,
cord-344093-3bniy5b5	124	6	type	type	NN
cord-344093-3bniy5b5	124	7	I	-PRON-	PRP
cord-344093-3bniy5b5	124	8	IFN	IFN	NNP
cord-344093-3bniy5b5	124	9	application	application	NN
cord-344093-3bniy5b5	124	10	after	after	IN
cord-344093-3bniy5b5	124	11	infection	infection	NN
cord-344093-3bniy5b5	124	12	has	have	VBZ
cord-344093-3bniy5b5	124	13	been	be	VBN
cord-344093-3bniy5b5	124	14	proven	prove	VBN
cord-344093-3bniy5b5	124	15	to	to	TO
cord-344093-3bniy5b5	124	16	drive	drive	VB
cord-344093-3bniy5b5	124	17	disease	disease	NN
cord-344093-3bniy5b5	124	18	severity	severity	NN
cord-344093-3bniy5b5	124	19	(	(	-LRB-
cord-344093-3bniy5b5	124	20	74	74	CD
cord-344093-3bniy5b5	124	21	)	)	-RRB-
cord-344093-3bniy5b5	124	22	.	.	.
cord-344093-3bniy5b5	125	1	Of	of	IN
cord-344093-3bniy5b5	125	2	note	note	NN
cord-344093-3bniy5b5	125	3	,	,	,
cord-344093-3bniy5b5	125	4	the	the	DT
cord-344093-3bniy5b5	125	5	detrimental	detrimental	JJ
cord-344093-3bniy5b5	125	6	effects	effect	NNS
cord-344093-3bniy5b5	125	7	of	of	IN
cord-344093-3bniy5b5	125	8	type	type	NN
cord-344093-3bniy5b5	125	9	I	-PRON-	PRP
cord-344093-3bniy5b5	125	10	IFNs	ifn	NNS
cord-344093-3bniy5b5	125	11	were	be	VBD
cord-344093-3bniy5b5	125	12	especially	especially	RB
cord-344093-3bniy5b5	125	13	pronounced	pronounce	VBN
cord-344093-3bniy5b5	125	14	in	in	IN
cord-344093-3bniy5b5	125	15	mice	mouse	NNS
cord-344093-3bniy5b5	125	16	lacking	lack	VBG
cord-344093-3bniy5b5	125	17	central	central	JJ
cord-344093-3bniy5b5	125	18	antiviral	antiviral	JJ
cord-344093-3bniy5b5	125	19	factors	factor	NNS
cord-344093-3bniy5b5	125	20	,	,	,
cord-344093-3bniy5b5	125	21	namely	namely	RB
cord-344093-3bniy5b5	125	22	the	the	DT
cord-344093-3bniy5b5	125	23	IFIT	ifit	NN
cord-344093-3bniy5b5	125	24	protein	protein	NN
cord-344093-3bniy5b5	125	25	in	in	IN
cord-344093-3bniy5b5	125	26	Sendai	Sendai	NNP
cord-344093-3bniy5b5	125	27	virus	virus	NN
cord-344093-3bniy5b5	125	28	infection	infection	NN
cord-344093-3bniy5b5	125	29	and	and	CC
cord-344093-3bniy5b5	125	30	MxA	mxa	NN
cord-344093-3bniy5b5	125	31	in	in	IN
cord-344093-3bniy5b5	125	32	IAV	IAV	NNP
cord-344093-3bniy5b5	125	33	.	.	.
cord-344093-3bniy5b5	126	1	Interestingly	interestingly	RB
cord-344093-3bniy5b5	126	2	,	,	,
cord-344093-3bniy5b5	126	3	Beilharz	Beilharz	NNP
cord-344093-3bniy5b5	126	4	et	et	NNP
cord-344093-3bniy5b5	126	5	al	al	NNP
cord-344093-3bniy5b5	126	6	.	.	.
cord-344093-3bniy5b5	127	1	(	(	-LRB-
cord-344093-3bniy5b5	127	2	77	77	CD
cord-344093-3bniy5b5	127	3	)	)	-RRB-
cord-344093-3bniy5b5	127	4	demonstrated	demonstrate	VBD
cord-344093-3bniy5b5	127	5	that	that	IN
cord-344093-3bniy5b5	127	6	application	application	NN
cord-344093-3bniy5b5	127	7	of	of	IN
cord-344093-3bniy5b5	127	8	low	low	JJ
cord-344093-3bniy5b5	127	9	doses	dose	NNS
cord-344093-3bniy5b5	127	10	of	of	IN
cord-344093-3bniy5b5	127	11	IFN	IFN	NNP
cord-344093-3bniy5b5	127	12	-	-	HYPH
cord-344093-3bniy5b5	127	13	α	α	NNP
cord-344093-3bniy5b5	127	14	reduces	reduce	VBZ
cord-344093-3bniy5b5	127	15	viral	viral	JJ
cord-344093-3bniy5b5	127	16	load	load	NN
cord-344093-3bniy5b5	127	17	,	,	,
cord-344093-3bniy5b5	127	18	which	which	WDT
cord-344093-3bniy5b5	127	19	to	to	IN
cord-344093-3bniy5b5	127	20	a	a	DT
cord-344093-3bniy5b5	127	21	certain	certain	JJ
cord-344093-3bniy5b5	127	22	degree	degree	NN
cord-344093-3bniy5b5	127	23	led	lead	VBD
cord-344093-3bniy5b5	127	24	to	to	IN
cord-344093-3bniy5b5	127	25	attenuated	attenuated	JJ
cord-344093-3bniy5b5	127	26	disease	disease	NN
cord-344093-3bniy5b5	127	27	progression	progression	NN
cord-344093-3bniy5b5	127	28	,	,	,
cord-344093-3bniy5b5	127	29	whereas	whereas	IN
cord-344093-3bniy5b5	127	30	high	high	JJ
cord-344093-3bniy5b5	127	31	dose	dose	NN
cord-344093-3bniy5b5	127	32	application	application	NN
cord-344093-3bniy5b5	127	33	of	of	IN
cord-344093-3bniy5b5	127	34	type	type	NN
cord-344093-3bniy5b5	127	35	I	-PRON-	PRP
cord-344093-3bniy5b5	127	36	IFN	IFN	NNP
cord-344093-3bniy5b5	127	37	contributed	contribute	VBD
cord-344093-3bniy5b5	127	38	to	to	IN
cord-344093-3bniy5b5	127	39	morbidity	morbidity	NN
cord-344093-3bniy5b5	127	40	(	(	-LRB-
cord-344093-3bniy5b5	127	41	77	77	CD
cord-344093-3bniy5b5	127	42	)	)	-RRB-
cord-344093-3bniy5b5	127	43	.	.	.
cord-344093-3bniy5b5	128	1	In	in	IN
cord-344093-3bniy5b5	128	2	line	line	NN
cord-344093-3bniy5b5	128	3	,	,	,
cord-344093-3bniy5b5	128	4	high	high	JJ
cord-344093-3bniy5b5	128	5	expression	expression	NN
cord-344093-3bniy5b5	128	6	levels	level	NNS
cord-344093-3bniy5b5	128	7	of	of	IN
cord-344093-3bniy5b5	128	8	ISGs	isg	NNS
cord-344093-3bniy5b5	128	9	have	have	VBP
cord-344093-3bniy5b5	128	10	been	be	VBN
cord-344093-3bniy5b5	128	11	shown	show	VBN
cord-344093-3bniy5b5	128	12	to	to	TO
cord-344093-3bniy5b5	128	13	correlate	correlate	VB
cord-344093-3bniy5b5	128	14	to	to	IN
cord-344093-3bniy5b5	128	15	worse	bad	JJR
cord-344093-3bniy5b5	128	16	outcomes	outcome	NNS
cord-344093-3bniy5b5	128	17	in	in	IN
cord-344093-3bniy5b5	128	18	ARDS	ARDS	NNP
cord-344093-3bniy5b5	128	19	patients	patient	NNS
cord-344093-3bniy5b5	128	20	(	(	-LRB-
cord-344093-3bniy5b5	128	21	78	78	CD
cord-344093-3bniy5b5	128	22	)	)	-RRB-
cord-344093-3bniy5b5	128	23	.	.	.
cord-344093-3bniy5b5	129	1	This	this	DT
cord-344093-3bniy5b5	129	2	observation	observation	NN
cord-344093-3bniy5b5	129	3	corresponds	correspond	VBZ
cord-344093-3bniy5b5	129	4	to	to	IN
cord-344093-3bniy5b5	129	5	reports	report	NNS
cord-344093-3bniy5b5	129	6	stating	state	VBG
cord-344093-3bniy5b5	129	7	that	that	IN
cord-344093-3bniy5b5	129	8	the	the	DT
cord-344093-3bniy5b5	129	9	IFN	IFN	NNP
cord-344093-3bniy5b5	129	10	threshold	threshold	NN
cord-344093-3bniy5b5	129	11	needed	need	VBN
cord-344093-3bniy5b5	129	12	to	to	TO
cord-344093-3bniy5b5	129	13	induce	induce	VB
cord-344093-3bniy5b5	129	14	antiviral	antiviral	JJ
cord-344093-3bniy5b5	129	15	ISGs	isg	NNS
cord-344093-3bniy5b5	129	16	-	-	:
cord-344093-3bniy5b5	129	17	showing	show	VBG
cord-344093-3bniy5b5	129	18	a	a	DT
cord-344093-3bniy5b5	129	19	beneficial	beneficial	JJ
cord-344093-3bniy5b5	129	20	effect	effect	NN
cord-344093-3bniy5b5	129	21	in	in	IN
cord-344093-3bniy5b5	129	22	acute	acute	JJ
cord-344093-3bniy5b5	129	23	respiratory	respiratory	JJ
cord-344093-3bniy5b5	129	24	viral	viral	JJ
cord-344093-3bniy5b5	129	25	infection	infection	NN
cord-344093-3bniy5b5	129	26	-	-	,
cord-344093-3bniy5b5	129	27	is	be	VBZ
cord-344093-3bniy5b5	129	28	by	by	IN
cord-344093-3bniy5b5	129	29	at	at	RB
cord-344093-3bniy5b5	129	30	least	least	RBS
cord-344093-3bniy5b5	129	31	10-fold	10-fold	CD
cord-344093-3bniy5b5	129	32	lower	low	JJR
cord-344093-3bniy5b5	129	33	than	than	IN
cord-344093-3bniy5b5	129	34	the	the	DT
cord-344093-3bniy5b5	129	35	IFN	IFN	NNP
cord-344093-3bniy5b5	129	36	dose	dose	NN
cord-344093-3bniy5b5	129	37	necessary	necessary	JJ
cord-344093-3bniy5b5	129	38	to	to	TO
cord-344093-3bniy5b5	129	39	trigger	trigger	VB
cord-344093-3bniy5b5	129	40	ISGs	isg	NNS
cord-344093-3bniy5b5	129	41	that	that	WDT
cord-344093-3bniy5b5	129	42	show	show	VBP
cord-344093-3bniy5b5	129	43	immunomodulatory	immunomodulatory	NN
cord-344093-3bniy5b5	129	44	,	,	,
cord-344093-3bniy5b5	129	45	death	death	NN
cord-344093-3bniy5b5	129	46	-	-	HYPH
cord-344093-3bniy5b5	129	47	inducing	induce	VBG
cord-344093-3bniy5b5	129	48	,	,	,
cord-344093-3bniy5b5	129	49	or	or	CC
cord-344093-3bniy5b5	129	50	anti	anti	JJ
cord-344093-3bniy5b5	129	51	-	-	JJ
cord-344093-3bniy5b5	129	52	proliferative	proliferative	JJ
cord-344093-3bniy5b5	129	53	effects	effect	NNS
cord-344093-3bniy5b5	129	54	and	and	CC
cord-344093-3bniy5b5	129	55	thus	thus	RB
cord-344093-3bniy5b5	129	56	can	can	MD
cord-344093-3bniy5b5	129	57	contribute	contribute	VB
cord-344093-3bniy5b5	129	58	to	to	IN
cord-344093-3bniy5b5	129	59	disease	disease	NN
cord-344093-3bniy5b5	129	60	progression	progression	NN
cord-344093-3bniy5b5	129	61	(	(	-LRB-
cord-344093-3bniy5b5	129	62	79	79	CD
cord-344093-3bniy5b5	129	63	)	)	-RRB-
cord-344093-3bniy5b5	130	1	(	(	-LRB-
cord-344093-3bniy5b5	130	2	80	80	CD
cord-344093-3bniy5b5	130	3	)	)	-RRB-
cord-344093-3bniy5b5	131	1	(	(	-LRB-
cord-344093-3bniy5b5	131	2	81	81	CD
cord-344093-3bniy5b5	131	3	)	)	-RRB-
cord-344093-3bniy5b5	131	4	(	(	-LRB-
cord-344093-3bniy5b5	131	5	82	82	CD
cord-344093-3bniy5b5	131	6	)	)	-RRB-
cord-344093-3bniy5b5	131	7	.	.	.
cord-344093-3bniy5b5	132	1	Altogether	altogether	RB
cord-344093-3bniy5b5	132	2	,	,	,
cord-344093-3bniy5b5	132	3	these	these	DT
cord-344093-3bniy5b5	132	4	data	datum	NNS
cord-344093-3bniy5b5	132	5	demonstrate	demonstrate	VBP
cord-344093-3bniy5b5	132	6	that	that	IN
cord-344093-3bniy5b5	132	7	IFNs	ifn	NNS
cord-344093-3bniy5b5	132	8	may	may	MD
cord-344093-3bniy5b5	132	9	significantly	significantly	RB
cord-344093-3bniy5b5	132	10	contribute	contribute	VB
cord-344093-3bniy5b5	132	11	to	to	IN
cord-344093-3bniy5b5	132	12	unbalanced	unbalanced	JJ
cord-344093-3bniy5b5	132	13	inflammation	inflammation	NN
cord-344093-3bniy5b5	132	14	and	and	CC
cord-344093-3bniy5b5	132	15	tissue	tissue	NN
cord-344093-3bniy5b5	132	16	injury	injury	NN
cord-344093-3bniy5b5	132	17	during	during	IN
cord-344093-3bniy5b5	132	18	respiratory	respiratory	JJ
cord-344093-3bniy5b5	132	19	viral	viral	JJ
cord-344093-3bniy5b5	132	20	infection	infection	NN
cord-344093-3bniy5b5	132	21	depending	depend	VBG
cord-344093-3bniy5b5	132	22	on	on	IN
cord-344093-3bniy5b5	132	23	expression	expression	NN
cord-344093-3bniy5b5	132	24	levels	level	NNS
cord-344093-3bniy5b5	132	25	and	and	CC
cord-344093-3bniy5b5	132	26	duration	duration	NN
cord-344093-3bniy5b5	132	27	of	of	IN
cord-344093-3bniy5b5	132	28	IFN	IFN	NNP
cord-344093-3bniy5b5	132	29	-	-	HYPH
cord-344093-3bniy5b5	132	30	related	relate	VBN
cord-344093-3bniy5b5	132	31	signaling	signal	VBG
cord-344093-3bniy5b5	132	32	events	event	NNS
cord-344093-3bniy5b5	132	33	.	.	.
cord-344093-3bniy5b5	133	1	To	to	IN
cord-344093-3bniy5b5	133	2	date	date	NN
cord-344093-3bniy5b5	133	3	,	,	,
cord-344093-3bniy5b5	133	4	the	the	DT
cord-344093-3bniy5b5	133	5	underlying	underlie	VBG
cord-344093-3bniy5b5	133	6	mechanisms	mechanism	NNS
cord-344093-3bniy5b5	133	7	leading	lead	VBG
cord-344093-3bniy5b5	133	8	to	to	IN
cord-344093-3bniy5b5	133	9	the	the	DT
cord-344093-3bniy5b5	133	10	IFNdependent	ifndependent	NN
cord-344093-3bniy5b5	133	11	enhanced	enhance	VBN
cord-344093-3bniy5b5	133	12	disease	disease	NN
cord-344093-3bniy5b5	133	13	progression	progression	NN
cord-344093-3bniy5b5	133	14	are	be	VBP
cord-344093-3bniy5b5	133	15	not	not	RB
cord-344093-3bniy5b5	133	16	fully	fully	RB
cord-344093-3bniy5b5	133	17	understood	understand	VBN
cord-344093-3bniy5b5	133	18	but	but	CC
cord-344093-3bniy5b5	133	19	often	often	RB
cord-344093-3bniy5b5	133	20	result	result	VBP
cord-344093-3bniy5b5	133	21	from	from	IN
cord-344093-3bniy5b5	133	22	a	a	DT
cord-344093-3bniy5b5	133	23	dysregulated	dysregulate	VBN
cord-344093-3bniy5b5	133	24	IFN	IFN	NNP
cord-344093-3bniy5b5	133	25	signaling	signal	VBG
cord-344093-3bniy5b5	133	26	response	response	NN
cord-344093-3bniy5b5	133	27	.	.	.
cord-344093-3bniy5b5	134	1	One	one	CD
cord-344093-3bniy5b5	134	2	mode	mode	NN
cord-344093-3bniy5b5	134	3	of	of	IN
cord-344093-3bniy5b5	134	4	action	action	NN
cord-344093-3bniy5b5	134	5	of	of	IN
cord-344093-3bniy5b5	134	6	IFN	IFN	NNP
cord-344093-3bniy5b5	134	7	and	and	CC
cord-344093-3bniy5b5	134	8	IFN	IFN	NNP
cord-344093-3bniy5b5	134	9	-	-	HYPH
cord-344093-3bniy5b5	134	10	stimulated	stimulate	VBN
cord-344093-3bniy5b5	134	11	ISGs	isg	NNS
cord-344093-3bniy5b5	134	12	is	be	VBZ
cord-344093-3bniy5b5	134	13	to	to	TO
cord-344093-3bniy5b5	134	14	stimulate	stimulate	VB
cord-344093-3bniy5b5	134	15	negative	negative	JJ
cord-344093-3bniy5b5	134	16	feedback	feedback	NN
cord-344093-3bniy5b5	134	17	loops	loop	NNS
cord-344093-3bniy5b5	134	18	on	on	IN
cord-344093-3bniy5b5	134	19	IFN	IFN	NNP
cord-344093-3bniy5b5	134	20	signaling	signal	VBG
cord-344093-3bniy5b5	134	21	.	.	.
cord-344093-3bniy5b5	135	1	For	for	IN
cord-344093-3bniy5b5	135	2	example	example	NN
cord-344093-3bniy5b5	135	3	,	,	,
cord-344093-3bniy5b5	135	4	suppression	suppression	NN
cord-344093-3bniy5b5	135	5	of	of	IN
cord-344093-3bniy5b5	135	6	JAK1	JAK1	NNP
cord-344093-3bniy5b5	135	7	or	or	CC
cord-344093-3bniy5b5	135	8	STAT1	stat1	XX
cord-344093-3bniy5b5	135	9	via	via	IN
cord-344093-3bniy5b5	135	10	specific	specific	JJ
cord-344093-3bniy5b5	135	11	phosphatases	phosphatase	NNS
cord-344093-3bniy5b5	135	12	,	,	,
cord-344093-3bniy5b5	135	13	expression	expression	NN
cord-344093-3bniy5b5	135	14	of	of	IN
cord-344093-3bniy5b5	135	15	suppressor	suppressor	NN
cord-344093-3bniy5b5	135	16	of	of	IN
cord-344093-3bniy5b5	135	17	cytokine	cytokine	NN
cord-344093-3bniy5b5	135	18	signaling	signaling	NN
cord-344093-3bniy5b5	135	19	(	(	-LRB-
cord-344093-3bniy5b5	135	20	SOCS)1	SOCS)1	NNP
cord-344093-3bniy5b5	135	21	and	and	CC
cord-344093-3bniy5b5	135	22	SOCS3	SOCS3	NNP
cord-344093-3bniy5b5	135	23	,	,	,
cord-344093-3bniy5b5	135	24	or	or	CC
cord-344093-3bniy5b5	135	25	ubiquitination	ubiquitination	NN
cord-344093-3bniy5b5	135	26	and	and	CC
cord-344093-3bniy5b5	135	27	endocytosis	endocytosis	NN
cord-344093-3bniy5b5	135	28	of	of	IN
cord-344093-3bniy5b5	135	29	the	the	DT
cord-344093-3bniy5b5	135	30	IFN	IFN	NNP
cord-344093-3bniy5b5	135	31	receptors	receptor	NNS
cord-344093-3bniy5b5	135	32	(	(	-LRB-
cord-344093-3bniy5b5	135	33	83	83	CD
cord-344093-3bniy5b5	135	34	)	)	-RRB-
cord-344093-3bniy5b5	135	35	(	(	-LRB-
cord-344093-3bniy5b5	135	36	84	84	CD
cord-344093-3bniy5b5	135	37	)	)	-RRB-
cord-344093-3bniy5b5	135	38	(	(	-LRB-
cord-344093-3bniy5b5	135	39	85	85	CD
cord-344093-3bniy5b5	135	40	)	)	-RRB-
cord-344093-3bniy5b5	135	41	(	(	-LRB-
cord-344093-3bniy5b5	135	42	86	86	CD
cord-344093-3bniy5b5	135	43	)	)	-RRB-
cord-344093-3bniy5b5	135	44	desensitize	desensitize	NN
cord-344093-3bniy5b5	135	45	cells	cell	NNS
cord-344093-3bniy5b5	135	46	to	to	IN
cord-344093-3bniy5b5	135	47	IFN	IFN	NNP
cord-344093-3bniy5b5	135	48	signaling	signal	VBG
cord-344093-3bniy5b5	135	49	and	and	CC
cord-344093-3bniy5b5	135	50	allow	allow	VB
cord-344093-3bniy5b5	135	51	recovery	recovery	NN
cord-344093-3bniy5b5	135	52	and	and	CC
cord-344093-3bniy5b5	135	53	the	the	DT
cord-344093-3bniy5b5	135	54	return	return	NN
cord-344093-3bniy5b5	135	55	to	to	IN
cord-344093-3bniy5b5	135	56	homeostasis	homeostasis	NN
cord-344093-3bniy5b5	135	57	after	after	IN
cord-344093-3bniy5b5	135	58	microbial	microbial	JJ
cord-344093-3bniy5b5	135	59	challenge	challenge	NN
cord-344093-3bniy5b5	135	60	.	.	.
cord-344093-3bniy5b5	136	1	As	as	IN
cord-344093-3bniy5b5	136	2	demonstrated	demonstrate	VBN
cord-344093-3bniy5b5	136	3	by	by	IN
cord-344093-3bniy5b5	136	4	Bhattacharya	Bhattacharya	NNP
cord-344093-3bniy5b5	136	5	et	et	NNP
cord-344093-3bniy5b5	136	6	al	al	NNP
cord-344093-3bniy5b5	136	7	.	.	.
cord-344093-3bniy5b5	137	1	(	(	-LRB-
cord-344093-3bniy5b5	137	2	87	87	CD
cord-344093-3bniy5b5	137	3	)	)	-RRB-
cord-344093-3bniy5b5	137	4	,	,	,
cord-344093-3bniy5b5	137	5	the	the	DT
cord-344093-3bniy5b5	137	6	lack	lack	NN
cord-344093-3bniy5b5	137	7	of	of	IN
cord-344093-3bniy5b5	137	8	IFNAR	IFNAR	NNP
cord-344093-3bniy5b5	137	9	downregulation	downregulation	NN
cord-344093-3bniy5b5	137	10	and	and	CC
cord-344093-3bniy5b5	137	11	thus	thus	RB
cord-344093-3bniy5b5	137	12	the	the	DT
cord-344093-3bniy5b5	137	13	failure	failure	NN
cord-344093-3bniy5b5	137	14	to	to	TO
cord-344093-3bniy5b5	137	15	initiate	initiate	VB
cord-344093-3bniy5b5	137	16	IFN	IFN	NNP
cord-344093-3bniy5b5	137	17	-	-	HYPH
cord-344093-3bniy5b5	137	18	desensitization	desensitization	NN
cord-344093-3bniy5b5	137	19	contributes	contribute	VBZ
cord-344093-3bniy5b5	137	20	to	to	IN
cord-344093-3bniy5b5	137	21	increased	increase	VBN
cord-344093-3bniy5b5	137	22	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	137	23	signaling	signaling	NN
cord-344093-3bniy5b5	137	24	,	,	,
cord-344093-3bniy5b5	137	25	extensive	extensive	JJ
cord-344093-3bniy5b5	137	26	lung	lung	NN
cord-344093-3bniy5b5	137	27	injury	injury	NN
cord-344093-3bniy5b5	137	28	and	and	CC
cord-344093-3bniy5b5	137	29	,	,	,
cord-344093-3bniy5b5	137	30	importantly	importantly	RB
cord-344093-3bniy5b5	137	31	,	,	,
cord-344093-3bniy5b5	137	32	also	also	RB
cord-344093-3bniy5b5	137	33	impaired	impair	VBD
cord-344093-3bniy5b5	137	34	tissue	tissue	NN
cord-344093-3bniy5b5	137	35	regeneration	regeneration	NN
cord-344093-3bniy5b5	137	36	(	(	-LRB-
cord-344093-3bniy5b5	137	37	87	87	CD
cord-344093-3bniy5b5	137	38	)	)	-RRB-
cord-344093-3bniy5b5	137	39	.	.	.
cord-344093-3bniy5b5	138	1	Moreover	moreover	RB
cord-344093-3bniy5b5	138	2	,	,	,
cord-344093-3bniy5b5	138	3	IFNs	ifn	NNS
cord-344093-3bniy5b5	138	4	are	be	VBP
cord-344093-3bniy5b5	138	5	immunomodulatory	immunomodulatory	JJ
cord-344093-3bniy5b5	138	6	and	and	CC
cord-344093-3bniy5b5	138	7	shape	shape	VB
cord-344093-3bniy5b5	138	8	the	the	DT
cord-344093-3bniy5b5	138	9	specific	specific	JJ
cord-344093-3bniy5b5	138	10	responses	response	NNS
cord-344093-3bniy5b5	138	11	of	of	IN
cord-344093-3bniy5b5	138	12	cells	cell	NNS
cord-344093-3bniy5b5	138	13	of	of	IN
cord-344093-3bniy5b5	138	14	the	the	DT
cord-344093-3bniy5b5	138	15	immune	immune	JJ
cord-344093-3bniy5b5	138	16	system	system	NN
cord-344093-3bniy5b5	138	17	,	,	,
cord-344093-3bniy5b5	138	18	which	which	WDT
cord-344093-3bniy5b5	138	19	has	have	VBZ
cord-344093-3bniy5b5	138	20	been	be	VBN
cord-344093-3bniy5b5	138	21	implied	imply	VBN
cord-344093-3bniy5b5	138	22	to	to	TO
cord-344093-3bniy5b5	138	23	influence	influence	VB
cord-344093-3bniy5b5	138	24	disease	disease	NN
cord-344093-3bniy5b5	138	25	progression	progression	NN
cord-344093-3bniy5b5	138	26	both	both	CC
cord-344093-3bniy5b5	138	27	positively	positively	RB
cord-344093-3bniy5b5	138	28	and	and	CC
cord-344093-3bniy5b5	138	29	negatively	negatively	RB
cord-344093-3bniy5b5	138	30	.	.	.
cord-344093-3bniy5b5	139	1	In	in	IN
cord-344093-3bniy5b5	139	2	a	a	DT
cord-344093-3bniy5b5	139	3	recent	recent	JJ
cord-344093-3bniy5b5	139	4	study	study	NN
cord-344093-3bniy5b5	139	5	,	,	,
cord-344093-3bniy5b5	139	6	type	type	NN
cord-344093-3bniy5b5	139	7	I	-PRON-	PRP
cord-344093-3bniy5b5	139	8	IFNs	ifns	VBP
cord-344093-3bniy5b5	139	9	have	have	VBP
cord-344093-3bniy5b5	139	10	been	be	VBN
cord-344093-3bniy5b5	139	11	associated	associate	VBN
cord-344093-3bniy5b5	139	12	in	in	IN
cord-344093-3bniy5b5	139	13	the	the	DT
cord-344093-3bniy5b5	139	14	regulation	regulation	NN
cord-344093-3bniy5b5	139	15	of	of	IN
cord-344093-3bniy5b5	139	16	innate	innate	JJ
cord-344093-3bniy5b5	139	17	lymphoid	lymphoid	JJ
cord-344093-3bniy5b5	139	18	immune	immune	JJ
cord-344093-3bniy5b5	139	19	cells	cell	NNS
cord-344093-3bniy5b5	139	20	(	(	-LRB-
cord-344093-3bniy5b5	139	21	ILC)2	ILC)2	NNP
cord-344093-3bniy5b5	139	22	in	in	IN
cord-344093-3bniy5b5	139	23	IAV	IAV	NNP
cord-344093-3bniy5b5	139	24	infection	infection	NN
cord-344093-3bniy5b5	139	25	,	,	,
cord-344093-3bniy5b5	139	26	where	where	WRB
cord-344093-3bniy5b5	139	27	they	-PRON-	PRP
cord-344093-3bniy5b5	139	28	-	-	HYPH
cord-344093-3bniy5b5	139	29	in	in	IN
cord-344093-3bniy5b5	139	30	concert	concert	NN
cord-344093-3bniy5b5	139	31	with	with	IN
cord-344093-3bniy5b5	139	32	IFN	IFN	NNP
cord-344093-3bniy5b5	139	33	-	-	HYPH
cord-344093-3bniy5b5	139	34	γ	γ	NNP
cord-344093-3bniy5b5	139	35	and	and	CC
cord-344093-3bniy5b5	139	36	IL-27-promote	IL-27-promote	NNP
cord-344093-3bniy5b5	140	1	an	an	DT
cord-344093-3bniy5b5	140	2	ILC2-dependent	ILC2-dependent	NNP
cord-344093-3bniy5b5	140	3	restriction	restriction	NN
cord-344093-3bniy5b5	140	4	of	of	IN
cord-344093-3bniy5b5	140	5	immunopathology	immunopathology	NN
cord-344093-3bniy5b5	140	6	(	(	-LRB-
cord-344093-3bniy5b5	140	7	88	88	CD
cord-344093-3bniy5b5	140	8	)	)	-RRB-
cord-344093-3bniy5b5	140	9	.	.	.
cord-344093-3bniy5b5	141	1	Moreover	moreover	RB
cord-344093-3bniy5b5	141	2	,	,	,
cord-344093-3bniy5b5	141	3	type	type	NN
cord-344093-3bniy5b5	141	4	I	-PRON-	PRP
cord-344093-3bniy5b5	141	5	IFNs	ifns	VBP
cord-344093-3bniy5b5	141	6	play	play	VB
cord-344093-3bniy5b5	141	7	an	an	DT
cord-344093-3bniy5b5	141	8	important	important	JJ
cord-344093-3bniy5b5	141	9	role	role	NN
cord-344093-3bniy5b5	141	10	in	in	IN
cord-344093-3bniy5b5	141	11	stimulating	stimulate	VBG
cord-344093-3bniy5b5	141	12	the	the	DT
cord-344093-3bniy5b5	141	13	immune	immune	JJ
cord-344093-3bniy5b5	141	14	response	response	NN
cord-344093-3bniy5b5	141	15	driven	drive	VBN
cord-344093-3bniy5b5	141	16	by	by	IN
cord-344093-3bniy5b5	141	17	DCs	dc	NNS
cord-344093-3bniy5b5	141	18	;	;	:
cord-344093-3bniy5b5	141	19	they	-PRON-	PRP
cord-344093-3bniy5b5	141	20	stimulate	stimulate	VBP
cord-344093-3bniy5b5	141	21	the	the	DT
cord-344093-3bniy5b5	141	22	expression	expression	NN
cord-344093-3bniy5b5	141	23	of	of	IN
cord-344093-3bniy5b5	141	24	MHC	MHC	NNP
cord-344093-3bniy5b5	141	25	molecules	molecule	NNS
cord-344093-3bniy5b5	141	26	as	as	RB
cord-344093-3bniy5b5	141	27	well	well	RB
cord-344093-3bniy5b5	141	28	as	as	IN
cord-344093-3bniy5b5	141	29	the	the	DT
cord-344093-3bniy5b5	141	30	co	co	JJ
cord-344093-3bniy5b5	141	31	-	-	JJ
cord-344093-3bniy5b5	141	32	stimulatory	stimulatory	JJ
cord-344093-3bniy5b5	141	33	ligands	ligand	NNS
cord-344093-3bniy5b5	141	34	CD80	CD80	NNP
cord-344093-3bniy5b5	141	35	and	and	CC
cord-344093-3bniy5b5	141	36	CD86	CD86	NNP
cord-344093-3bniy5b5	141	37	and	and	CC
cord-344093-3bniy5b5	141	38	thus	thus	RB
cord-344093-3bniy5b5	141	39	activate	activate	VB
cord-344093-3bniy5b5	141	40	T	T	NNP
cord-344093-3bniy5b5	141	41	cell	cell	NN
cord-344093-3bniy5b5	141	42	responses	response	NNS
cord-344093-3bniy5b5	141	43	(	(	-LRB-
cord-344093-3bniy5b5	141	44	89	89	CD
cord-344093-3bniy5b5	141	45	,	,	,
cord-344093-3bniy5b5	141	46	90	90	CD
cord-344093-3bniy5b5	141	47	)	)	-RRB-
cord-344093-3bniy5b5	141	48	.	.	.
cord-344093-3bniy5b5	142	1	Additionally	additionally	RB
cord-344093-3bniy5b5	142	2	,	,	,
cord-344093-3bniy5b5	142	3	ligand	ligand	NN
cord-344093-3bniy5b5	142	4	-	-	HYPH
cord-344093-3bniy5b5	142	5	driven	drive	VBN
cord-344093-3bniy5b5	142	6	activation	activation	NN
cord-344093-3bniy5b5	142	7	of	of	IN
cord-344093-3bniy5b5	142	8	IFNAR	IFNAR	NNP
cord-344093-3bniy5b5	142	9	enhances	enhance	VBZ
cord-344093-3bniy5b5	142	10	the	the	DT
cord-344093-3bniy5b5	142	11	proliferation	proliferation	NN
cord-344093-3bniy5b5	142	12	of	of	IN
cord-344093-3bniy5b5	142	13	CD8	CD8	NNP
cord-344093-3bniy5b5	142	14	positive	positive	JJ
cord-344093-3bniy5b5	142	15	T	T	NNP
cord-344093-3bniy5b5	142	16	cells	cell	NNS
cord-344093-3bniy5b5	142	17	,	,	,
cord-344093-3bniy5b5	142	18	especially	especially	RB
cord-344093-3bniy5b5	142	19	early	early	RB
cord-344093-3bniy5b5	142	20	in	in	IN
cord-344093-3bniy5b5	142	21	infection	infection	NN
cord-344093-3bniy5b5	142	22	.	.	.
cord-344093-3bniy5b5	143	1	However	however	RB
cord-344093-3bniy5b5	143	2	,	,	,
cord-344093-3bniy5b5	143	3	late	late	RB
cord-344093-3bniy5b5	143	4	in	in	IN
cord-344093-3bniy5b5	143	5	infection	infection	NN
cord-344093-3bniy5b5	143	6	,	,	,
cord-344093-3bniy5b5	143	7	type	type	NN
cord-344093-3bniy5b5	143	8	I	-PRON-	PRP
cord-344093-3bniy5b5	143	9	IFNs	ifn	NNS
cord-344093-3bniy5b5	143	10	were	be	VBD
cord-344093-3bniy5b5	143	11	also	also	RB
cord-344093-3bniy5b5	143	12	implied	imply	VBN
cord-344093-3bniy5b5	143	13	in	in	IN
cord-344093-3bniy5b5	143	14	decreasing	decrease	VBG
cord-344093-3bniy5b5	143	15	T	T	NNP
cord-344093-3bniy5b5	143	16	cell	cell	NN
cord-344093-3bniy5b5	143	17	expansion	expansion	NN
cord-344093-3bniy5b5	143	18	upon	upon	IN
cord-344093-3bniy5b5	143	19	SARS	SARS	NNP
cord-344093-3bniy5b5	143	20	-	-	HYPH
cord-344093-3bniy5b5	143	21	CoV	CoV	NNP
cord-344093-3bniy5b5	143	22	and	and	CC
cord-344093-3bniy5b5	143	23	arenavirus	arenavirus	NNP
cord-344093-3bniy5b5	143	24	infection	infection	NN
cord-344093-3bniy5b5	143	25	(	(	-LRB-
cord-344093-3bniy5b5	143	26	76	76	CD
cord-344093-3bniy5b5	143	27	,	,	,
cord-344093-3bniy5b5	143	28	91	91	CD
cord-344093-3bniy5b5	143	29	)	)	-RRB-
cord-344093-3bniy5b5	143	30	,	,	,
cord-344093-3bniy5b5	143	31	which	which	WDT
cord-344093-3bniy5b5	143	32	might	may	MD
cord-344093-3bniy5b5	143	33	potentially	potentially	RB
cord-344093-3bniy5b5	143	34	be	be	VB
cord-344093-3bniy5b5	143	35	related	relate	VBN
cord-344093-3bniy5b5	143	36	to	to	IN
cord-344093-3bniy5b5	143	37	the	the	DT
cord-344093-3bniy5b5	143	38	above	above	RB
cord-344093-3bniy5b5	143	39	described	describe	VBN
cord-344093-3bniy5b5	143	40	desensitization	desensitization	NN
cord-344093-3bniy5b5	143	41	upon	upon	IN
cord-344093-3bniy5b5	143	42	prolonged	prolong	VBN
cord-344093-3bniy5b5	143	43	IFN	IFN	NNP
cord-344093-3bniy5b5	143	44	signaling	signal	VBG
cord-344093-3bniy5b5	143	45	and	and	CC
cord-344093-3bniy5b5	143	46	might	may	MD
cord-344093-3bniy5b5	143	47	be	be	VB
cord-344093-3bniy5b5	143	48	detrimental	detrimental	JJ
cord-344093-3bniy5b5	143	49	if	if	IN
cord-344093-3bniy5b5	143	50	initiated	initiate	VBN
cord-344093-3bniy5b5	143	51	too	too	RB
cord-344093-3bniy5b5	143	52	early	early	RB
cord-344093-3bniy5b5	143	53	in	in	IN
cord-344093-3bniy5b5	143	54	infection	infection	NN
cord-344093-3bniy5b5	143	55	.	.	.
cord-344093-3bniy5b5	144	1	In	in	IN
cord-344093-3bniy5b5	144	2	line	line	NN
cord-344093-3bniy5b5	144	3	,	,	,
cord-344093-3bniy5b5	144	4	Pinto	Pinto	NNP
cord-344093-3bniy5b5	144	5	et	et	NNP
cord-344093-3bniy5b5	144	6	al	al	NNP
cord-344093-3bniy5b5	144	7	.	.	.
cord-344093-3bniy5b5	145	1	(	(	-LRB-
cord-344093-3bniy5b5	145	2	92	92	CD
cord-344093-3bniy5b5	145	3	)	)	-RRB-
cord-344093-3bniy5b5	145	4	reported	report	VBD
cord-344093-3bniy5b5	145	5	an	an	DT
cord-344093-3bniy5b5	145	6	impairment	impairment	NN
cord-344093-3bniy5b5	145	7	of	of	IN
cord-344093-3bniy5b5	145	8	T	t	NN
cord-344093-3bniy5b5	145	9	cell	cell	NN
cord-344093-3bniy5b5	145	10	responses	response	NNS
cord-344093-3bniy5b5	145	11	upon	upon	IN
cord-344093-3bniy5b5	145	12	type	type	NN
cord-344093-3bniy5b5	145	13	IFN	IFN	NNP
cord-344093-3bniy5b5	145	14	induction	induction	NN
cord-344093-3bniy5b5	145	15	in	in	IN
cord-344093-3bniy5b5	145	16	West	West	NNP
cord-344093-3bniy5b5	145	17	Nile	Nile	NNP
cord-344093-3bniy5b5	145	18	virus	virus	NN
cord-344093-3bniy5b5	145	19	infection	infection	NN
cord-344093-3bniy5b5	145	20	.	.	.
cord-344093-3bniy5b5	146	1	In	in	IN
cord-344093-3bniy5b5	146	2	B	b	NN
cord-344093-3bniy5b5	146	3	cells	cell	NNS
cord-344093-3bniy5b5	146	4	,	,	,
cord-344093-3bniy5b5	146	5	the	the	DT
cord-344093-3bniy5b5	146	6	lack	lack	NN
cord-344093-3bniy5b5	146	7	of	of	IN
cord-344093-3bniy5b5	146	8	IFNAR	IFNAR	NNP
cord-344093-3bniy5b5	146	9	has	have	VBZ
cord-344093-3bniy5b5	146	10	been	be	VBN
cord-344093-3bniy5b5	146	11	demonstrated	demonstrate	VBN
cord-344093-3bniy5b5	146	12	to	to	TO
cord-344093-3bniy5b5	146	13	result	result	VB
cord-344093-3bniy5b5	146	14	in	in	IN
cord-344093-3bniy5b5	146	15	enhanced	enhanced	JJ
cord-344093-3bniy5b5	146	16	release	release	NN
cord-344093-3bniy5b5	146	17	of	of	IN
cord-344093-3bniy5b5	146	18	neutralizing	neutralize	VBG
cord-344093-3bniy5b5	146	19	antibodies	antibody	NNS
cord-344093-3bniy5b5	146	20	in	in	IN
cord-344093-3bniy5b5	146	21	IAV	IAV	NNP
cord-344093-3bniy5b5	146	22	infection	infection	NN
cord-344093-3bniy5b5	146	23	(	(	-LRB-
cord-344093-3bniy5b5	146	24	93	93	CD
cord-344093-3bniy5b5	146	25	)	)	-RRB-
cord-344093-3bniy5b5	146	26	implying	imply	VBG
cord-344093-3bniy5b5	146	27	a	a	DT
cord-344093-3bniy5b5	146	28	repressive	repressive	JJ
cord-344093-3bniy5b5	146	29	role	role	NN
cord-344093-3bniy5b5	146	30	for	for	IN
cord-344093-3bniy5b5	146	31	type	type	NN
cord-344093-3bniy5b5	147	1	I	-PRON-	PRP
cord-344093-3bniy5b5	147	2	IFN	IFN	NNP
cord-344093-3bniy5b5	147	3	in	in	IN
cord-344093-3bniy5b5	147	4	B	B	NNP
cord-344093-3bniy5b5	147	5	cell	cell	NN
cord-344093-3bniy5b5	147	6	antibody	antibody	NN
cord-344093-3bniy5b5	147	7	production	production	NN
cord-344093-3bniy5b5	147	8	.	.	.
cord-344093-3bniy5b5	148	1	However	however	RB
cord-344093-3bniy5b5	148	2	,	,	,
cord-344093-3bniy5b5	148	3	immunization	immunization	NN
cord-344093-3bniy5b5	148	4	studies	study	NNS
cord-344093-3bniy5b5	148	5	by	by	IN
cord-344093-3bniy5b5	148	6	Le	Le	NNP
cord-344093-3bniy5b5	148	7	Bon	Bon	NNP
cord-344093-3bniy5b5	148	8	et	et	FW
cord-344093-3bniy5b5	148	9	al	al	NNP
cord-344093-3bniy5b5	148	10	.	.	.
cord-344093-3bniy5b5	149	1	(	(	-LRB-
cord-344093-3bniy5b5	149	2	94	94	CD
cord-344093-3bniy5b5	149	3	)	)	-RRB-
cord-344093-3bniy5b5	149	4	reported	report	VBD
cord-344093-3bniy5b5	149	5	the	the	DT
cord-344093-3bniy5b5	149	6	necessity	necessity	NN
cord-344093-3bniy5b5	149	7	of	of	IN
cord-344093-3bniy5b5	149	8	IFNAR	IFNAR	NNP
cord-344093-3bniy5b5	149	9	on	on	IN
cord-344093-3bniy5b5	149	10	B	b	NN
cord-344093-3bniy5b5	149	11	cells	cell	NNS
cord-344093-3bniy5b5	149	12	for	for	IN
cord-344093-3bniy5b5	149	13	efficient	efficient	JJ
cord-344093-3bniy5b5	149	14	IgM	IgM	NNP
cord-344093-3bniy5b5	149	15	and	and	CC
cord-344093-3bniy5b5	149	16	IgG	IgG	NNP
cord-344093-3bniy5b5	149	17	production	production	NN
cord-344093-3bniy5b5	149	18	,	,	,
cord-344093-3bniy5b5	149	19	underlining	underline	VBG
cord-344093-3bniy5b5	149	20	the	the	DT
cord-344093-3bniy5b5	149	21	need	need	NN
cord-344093-3bniy5b5	149	22	for	for	IN
cord-344093-3bniy5b5	149	23	further	further	JJ
cord-344093-3bniy5b5	149	24	studies	study	NNS
cord-344093-3bniy5b5	149	25	to	to	TO
cord-344093-3bniy5b5	149	26	understand	understand	VB
cord-344093-3bniy5b5	149	27	the	the	DT
cord-344093-3bniy5b5	149	28	detailed	detailed	JJ
cord-344093-3bniy5b5	149	29	effects	effect	NNS
cord-344093-3bniy5b5	149	30	of	of	IN
cord-344093-3bniy5b5	149	31	IFN	IFN	NNP
cord-344093-3bniy5b5	149	32	-	-	HYPH
cord-344093-3bniy5b5	149	33	dosage	dosage	NN
cord-344093-3bniy5b5	149	34	and	and	CC
cord-344093-3bniy5b5	149	35	timing	time	VBG
cord-344093-3bniy5b5	149	36	adaptive	adaptive	JJ
cord-344093-3bniy5b5	149	37	immunity	immunity	NN
cord-344093-3bniy5b5	149	38	activity	activity	NN
cord-344093-3bniy5b5	149	39	upon	upon	IN
cord-344093-3bniy5b5	149	40	respiratory	respiratory	JJ
cord-344093-3bniy5b5	149	41	viral	viral	JJ
cord-344093-3bniy5b5	149	42	infection	infection	NN
cord-344093-3bniy5b5	149	43	.	.	.
cord-344093-3bniy5b5	150	1	Type	type	NN
cord-344093-3bniy5b5	150	2	I	-PRON-	PRP
cord-344093-3bniy5b5	150	3	IFNs	ifn	NNS
cord-344093-3bniy5b5	150	4	additionally	additionally	RB
cord-344093-3bniy5b5	150	5	induce	induce	VBP
cord-344093-3bniy5b5	150	6	the	the	DT
cord-344093-3bniy5b5	150	7	production	production	NN
cord-344093-3bniy5b5	150	8	of	of	IN
cord-344093-3bniy5b5	150	9	high	high	JJ
cord-344093-3bniy5b5	150	10	levels	level	NNS
cord-344093-3bniy5b5	150	11	of	of	IN
cord-344093-3bniy5b5	150	12	pro	pro	JJ
cord-344093-3bniy5b5	150	13	-	-	JJ
cord-344093-3bniy5b5	150	14	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	150	15	cytokines	cytokine	NNS
cord-344093-3bniy5b5	150	16	that	that	WDT
cord-344093-3bniy5b5	150	17	have	have	VBP
cord-344093-3bniy5b5	150	18	been	be	VBN
cord-344093-3bniy5b5	150	19	closely	closely	RB
cord-344093-3bniy5b5	150	20	linked	link	VBN
cord-344093-3bniy5b5	150	21	to	to	IN
cord-344093-3bniy5b5	150	22	worsened	worsen	VBN
cord-344093-3bniy5b5	150	23	outcomes	outcome	NNS
cord-344093-3bniy5b5	150	24	of	of	IN
cord-344093-3bniy5b5	150	25	acute	acute	JJ
cord-344093-3bniy5b5	150	26	respiratory	respiratory	JJ
cord-344093-3bniy5b5	150	27	viral	viral	JJ
cord-344093-3bniy5b5	150	28	infection	infection	NN
cord-344093-3bniy5b5	150	29	.	.	.
cord-344093-3bniy5b5	151	1	Especially	especially	RB
cord-344093-3bniy5b5	151	2	in	in	IN
cord-344093-3bniy5b5	151	3	IAV	IAV	NNP
cord-344093-3bniy5b5	151	4	,	,	,
cord-344093-3bniy5b5	151	5	disease	disease	NN
cord-344093-3bniy5b5	151	6	severity	severity	NN
cord-344093-3bniy5b5	151	7	and	and	CC
cord-344093-3bniy5b5	151	8	disease	disease	NN
cord-344093-3bniy5b5	151	9	progression	progression	NN
cord-344093-3bniy5b5	151	10	are	be	VBP
cord-344093-3bniy5b5	151	11	linked	link	VBN
cord-344093-3bniy5b5	151	12	with	with	IN
cord-344093-3bniy5b5	151	13	an	an	DT
cord-344093-3bniy5b5	151	14	overshooting	overshooting	NN
cord-344093-3bniy5b5	151	15	,	,	,
cord-344093-3bniy5b5	151	16	IFN	IFN	NNP
cord-344093-3bniy5b5	151	17	-	-	HYPH
cord-344093-3bniy5b5	151	18	driven	drive	VBN
cord-344093-3bniy5b5	151	19	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	151	20	response	response	NN
cord-344093-3bniy5b5	151	21	,	,	,
cord-344093-3bniy5b5	151	22	in	in	IN
cord-344093-3bniy5b5	151	23	which	which	WDT
cord-344093-3bniy5b5	151	24	further	further	JJ
cord-344093-3bniy5b5	151	25	exogenous	exogenous	JJ
cord-344093-3bniy5b5	151	26	supplementation	supplementation	NN
cord-344093-3bniy5b5	151	27	with	with	IN
cord-344093-3bniy5b5	151	28	type	type	NN
cord-344093-3bniy5b5	152	1	I	-PRON-	PRP
cord-344093-3bniy5b5	152	2	IFN	IFN	NNP
cord-344093-3bniy5b5	152	3	in	in	IN
cord-344093-3bniy5b5	152	4	fact	fact	NN
cord-344093-3bniy5b5	152	5	correlates	correlate	VBZ
cord-344093-3bniy5b5	152	6	with	with	IN
cord-344093-3bniy5b5	152	7	increased	increase	VBN
cord-344093-3bniy5b5	152	8	morbidity	morbidity	NN
cord-344093-3bniy5b5	152	9	and	and	CC
cord-344093-3bniy5b5	152	10	mortality	mortality	NN
cord-344093-3bniy5b5	152	11	(	(	-LRB-
cord-344093-3bniy5b5	152	12	74	74	CD
cord-344093-3bniy5b5	152	13	,	,	,
cord-344093-3bniy5b5	152	14	95	95	CD
cord-344093-3bniy5b5	152	15	)	)	-RRB-
cord-344093-3bniy5b5	152	16	.	.	.
cord-344093-3bniy5b5	153	1	In	in	IN
cord-344093-3bniy5b5	153	2	non	non	JJ
cord-344093-3bniy5b5	153	3	-	-	JJ
cord-344093-3bniy5b5	153	4	human	human	JJ
cord-344093-3bniy5b5	153	5	primates	primate	NNS
cord-344093-3bniy5b5	153	6	,	,	,
cord-344093-3bniy5b5	153	7	IAV	IAV	NNP
cord-344093-3bniy5b5	153	8	infection	infection	NN
cord-344093-3bniy5b5	153	9	with	with	IN
cord-344093-3bniy5b5	153	10	a	a	DT
cord-344093-3bniy5b5	153	11	highly	highly	RB
cord-344093-3bniy5b5	153	12	pathogenic	pathogenic	JJ
cord-344093-3bniy5b5	153	13	H5N1	H5N1	NNP
cord-344093-3bniy5b5	153	14	isolate	isolate	VB
cord-344093-3bniy5b5	153	15	evokes	evoke	VBZ
cord-344093-3bniy5b5	153	16	a	a	DT
cord-344093-3bniy5b5	153	17	strong	strong	JJ
cord-344093-3bniy5b5	153	18	induction	induction	NN
cord-344093-3bniy5b5	153	19	of	of	IN
cord-344093-3bniy5b5	153	20	type	type	NN
cord-344093-3bniy5b5	153	21	I	-PRON-	PRP
cord-344093-3bniy5b5	153	22	IFN	IFN	NNP
cord-344093-3bniy5b5	153	23	,	,	,
cord-344093-3bniy5b5	153	24	resulting	result	VBG
cord-344093-3bniy5b5	153	25	in	in	IN
cord-344093-3bniy5b5	153	26	severe	severe	JJ
cord-344093-3bniy5b5	153	27	lung	lung	NN
cord-344093-3bniy5b5	153	28	injury	injury	NN
cord-344093-3bniy5b5	153	29	by	by	IN
cord-344093-3bniy5b5	153	30	a	a	DT
cord-344093-3bniy5b5	153	31	necrotizing	necrotize	VBG
cord-344093-3bniy5b5	153	32	bronchiolitis	bronchiolitis	NN
cord-344093-3bniy5b5	153	33	and	and	CC
cord-344093-3bniy5b5	153	34	alveolotis	alveolotis	NNP
cord-344093-3bniy5b5	153	35	(	(	-LRB-
cord-344093-3bniy5b5	153	36	96	96	CD
cord-344093-3bniy5b5	153	37	)	)	-RRB-
cord-344093-3bniy5b5	153	38	.	.	.
cord-344093-3bniy5b5	154	1	IFN	IFN	NNP
cord-344093-3bniy5b5	154	2	levels	level	NNS
cord-344093-3bniy5b5	154	3	in	in	IN
cord-344093-3bniy5b5	154	4	turn	turn	NN
cord-344093-3bniy5b5	154	5	have	have	VBP
cord-344093-3bniy5b5	154	6	been	be	VBN
cord-344093-3bniy5b5	154	7	demonstrated	demonstrate	VBN
cord-344093-3bniy5b5	154	8	to	to	TO
cord-344093-3bniy5b5	154	9	cause	cause	VB
cord-344093-3bniy5b5	154	10	elevated	elevated	JJ
cord-344093-3bniy5b5	154	11	pro	pro	JJ
cord-344093-3bniy5b5	154	12	-	-	JJ
cord-344093-3bniy5b5	154	13	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	154	14	cytokine	cytokine	NN
cord-344093-3bniy5b5	154	15	levels	level	NNS
cord-344093-3bniy5b5	154	16	after	after	IN
cord-344093-3bniy5b5	154	17	in	in	IN
cord-344093-3bniy5b5	154	18	vivo	vivo	NNP
cord-344093-3bniy5b5	154	19	IAV	IAV	NNP
cord-344093-3bniy5b5	154	20	infection	infection	NN
cord-344093-3bniy5b5	154	21	and	and	CC
cord-344093-3bniy5b5	154	22	additionally	additionally	RB
cord-344093-3bniy5b5	154	23	,	,	,
cord-344093-3bniy5b5	154	24	in	in	IN
cord-344093-3bniy5b5	154	25	human	human	JJ
cord-344093-3bniy5b5	154	26	alveolar	alveolar	NN
cord-344093-3bniy5b5	154	27	macrophages	macrophage	NNS
cord-344093-3bniy5b5	154	28	,	,	,
cord-344093-3bniy5b5	154	29	the	the	DT
cord-344093-3bniy5b5	154	30	release	release	NN
cord-344093-3bniy5b5	154	31	of	of	IN
cord-344093-3bniy5b5	154	32	pro	pro	JJ
cord-344093-3bniy5b5	154	33	-	-	JJ
cord-344093-3bniy5b5	154	34	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	154	35	cytokines	cytokine	NNS
cord-344093-3bniy5b5	154	36	(	(	-LRB-
cord-344093-3bniy5b5	154	37	e.g.	e.g.	RB
cord-344093-3bniy5b5	154	38	,	,	,
cord-344093-3bniy5b5	154	39	MCP-1	MCP-1	NNP
cord-344093-3bniy5b5	154	40	)	)	-RRB-
cord-344093-3bniy5b5	154	41	are	be	VBP
cord-344093-3bniy5b5	154	42	preceded	precede	VBN
cord-344093-3bniy5b5	154	43	by	by	IN
cord-344093-3bniy5b5	154	44	a	a	DT
cord-344093-3bniy5b5	154	45	robust	robust	JJ
cord-344093-3bniy5b5	154	46	type	type	NN
cord-344093-3bniy5b5	155	1	I	-PRON-	PRP
cord-344093-3bniy5b5	155	2	IFN	IFN	NNP
cord-344093-3bniy5b5	155	3	response	response	NN
cord-344093-3bniy5b5	155	4	(	(	-LRB-
cord-344093-3bniy5b5	155	5	97	97	CD
cord-344093-3bniy5b5	155	6	)	)	-RRB-
cord-344093-3bniy5b5	155	7	.	.	.
cord-344093-3bniy5b5	156	1	Importantly	importantly	RB
cord-344093-3bniy5b5	156	2	,	,	,
cord-344093-3bniy5b5	156	3	also	also	RB
cord-344093-3bniy5b5	156	4	in	in	IN
cord-344093-3bniy5b5	156	5	human	human	JJ
cord-344093-3bniy5b5	156	6	infection	infection	NN
cord-344093-3bniy5b5	156	7	with	with	IN
cord-344093-3bniy5b5	156	8	H5N1	H5N1	NNP
cord-344093-3bniy5b5	156	9	,	,	,
cord-344093-3bniy5b5	156	10	levels	level	NNS
cord-344093-3bniy5b5	156	11	of	of	IN
cord-344093-3bniy5b5	156	12	pro	pro	JJ
cord-344093-3bniy5b5	156	13	-	-	JJ
cord-344093-3bniy5b5	156	14	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	156	15	cytokines	cytokine	NNS
cord-344093-3bniy5b5	156	16	are	be	VBP
cord-344093-3bniy5b5	156	17	strongly	strongly	RB
cord-344093-3bniy5b5	156	18	elevated	elevate	VBN
cord-344093-3bniy5b5	156	19	in	in	IN
cord-344093-3bniy5b5	156	20	bronchoalveolar	bronchoalveolar	NNP
cord-344093-3bniy5b5	156	21	lavage	lavage	NN
cord-344093-3bniy5b5	156	22	fluid	fluid	NN
cord-344093-3bniy5b5	156	23	,	,	,
cord-344093-3bniy5b5	156	24	and	and	CC
cord-344093-3bniy5b5	156	25	cytokine	cytokine	NN
cord-344093-3bniy5b5	156	26	levels	level	NNS
cord-344093-3bniy5b5	156	27	have	have	VBP
cord-344093-3bniy5b5	156	28	been	be	VBN
cord-344093-3bniy5b5	156	29	associated	associate	VBN
cord-344093-3bniy5b5	156	30	with	with	IN
cord-344093-3bniy5b5	156	31	organ	organ	NN
cord-344093-3bniy5b5	156	32	damage	damage	NN
cord-344093-3bniy5b5	156	33	and	and	CC
cord-344093-3bniy5b5	156	34	worsened	worsen	VBD
cord-344093-3bniy5b5	156	35	disease	disease	NN
cord-344093-3bniy5b5	156	36	outcomes	outcome	NNS
cord-344093-3bniy5b5	156	37	(	(	-LRB-
cord-344093-3bniy5b5	156	38	98	98	CD
cord-344093-3bniy5b5	156	39	,	,	,
cord-344093-3bniy5b5	156	40	99	99	CD
cord-344093-3bniy5b5	156	41	)	)	-RRB-
cord-344093-3bniy5b5	156	42	.	.	.
cord-344093-3bniy5b5	157	1	Still	still	RB
cord-344093-3bniy5b5	157	2	,	,	,
cord-344093-3bniy5b5	157	3	it	-PRON-	PRP
cord-344093-3bniy5b5	157	4	should	should	MD
cord-344093-3bniy5b5	157	5	be	be	VB
cord-344093-3bniy5b5	157	6	noted	note	VBN
cord-344093-3bniy5b5	157	7	that	that	IN
cord-344093-3bniy5b5	157	8	due	due	IN
cord-344093-3bniy5b5	157	9	to	to	TO
cord-344093-3bniy5b5	157	10	strain	strain	VB
cord-344093-3bniy5b5	157	11	differences	difference	NNS
cord-344093-3bniy5b5	157	12	in	in	IN
cord-344093-3bniy5b5	157	13	virus	virus	NN
cord-344093-3bniy5b5	157	14	-	-	HYPH
cord-344093-3bniy5b5	157	15	elicited	elicit	VBN
cord-344093-3bniy5b5	157	16	PRR	PRR	NNP
cord-344093-3bniy5b5	157	17	activation	activation	NN
cord-344093-3bniy5b5	157	18	and	and	CC
cord-344093-3bniy5b5	157	19	,	,	,
cord-344093-3bniy5b5	157	20	importantly	importantly	RB
cord-344093-3bniy5b5	157	21	,	,	,
cord-344093-3bniy5b5	157	22	IFN	IFN	NNP
cord-344093-3bniy5b5	157	23	antagonism	antagonism	NN
cord-344093-3bniy5b5	157	24	by	by	IN
cord-344093-3bniy5b5	157	25	the	the	DT
cord-344093-3bniy5b5	157	26	IAV	IAV	NNP
cord-344093-3bniy5b5	157	27	non	non	JJ
cord-344093-3bniy5b5	157	28	-	-	JJ
cord-344093-3bniy5b5	157	29	structural	structural	JJ
cord-344093-3bniy5b5	157	30	(	(	-LRB-
cord-344093-3bniy5b5	157	31	NS)1	NS)1	NNP
cord-344093-3bniy5b5	157	32	protein	protein	NN
cord-344093-3bniy5b5	157	33	,	,	,
cord-344093-3bniy5b5	157	34	IFN	IFN	NNP
cord-344093-3bniy5b5	157	35	levels	level	NNS
cord-344093-3bniy5b5	157	36	and	and	CC
cord-344093-3bniy5b5	157	37	disease	disease	NN
cord-344093-3bniy5b5	157	38	severity	severity	NN
cord-344093-3bniy5b5	157	39	do	do	VBP
cord-344093-3bniy5b5	157	40	not	not	RB
cord-344093-3bniy5b5	157	41	always	always	RB
cord-344093-3bniy5b5	157	42	directly	directly	RB
cord-344093-3bniy5b5	157	43	correlate	correlate	VB
cord-344093-3bniy5b5	157	44	;	;	:
cord-344093-3bniy5b5	157	45	actually	actually	RB
cord-344093-3bniy5b5	157	46	,	,	,
cord-344093-3bniy5b5	157	47	the	the	DT
cord-344093-3bniy5b5	157	48	extent	extent	NN
cord-344093-3bniy5b5	157	49	to	to	TO
cord-344093-3bniy5b5	157	50	which	which	WDT
cord-344093-3bniy5b5	157	51	NS1	ns1	NN
cord-344093-3bniy5b5	157	52	can	can	MD
cord-344093-3bniy5b5	157	53	suppress	suppress	VB
cord-344093-3bniy5b5	157	54	the	the	DT
cord-344093-3bniy5b5	157	55	IFN	IFN	NNP
cord-344093-3bniy5b5	157	56	response	response	NN
cord-344093-3bniy5b5	157	57	relates	relate	VBZ
cord-344093-3bniy5b5	157	58	to	to	IN
cord-344093-3bniy5b5	157	59	prolonged	prolong	VBN
cord-344093-3bniy5b5	157	60	viremia	viremia	NN
cord-344093-3bniy5b5	157	61	and	and	CC
cord-344093-3bniy5b5	157	62	thus	thus	RB
cord-344093-3bniy5b5	157	63	can	can	MD
cord-344093-3bniy5b5	157	64	also	also	RB
cord-344093-3bniy5b5	157	65	be	be	VB
cord-344093-3bniy5b5	157	66	a	a	DT
cord-344093-3bniy5b5	157	67	determinant	determinant	NN
cord-344093-3bniy5b5	157	68	of	of	IN
cord-344093-3bniy5b5	157	69	virus	virus	NN
cord-344093-3bniy5b5	157	70	pathogenicity	pathogenicity	NN
cord-344093-3bniy5b5	157	71	both	both	CC
cord-344093-3bniy5b5	157	72	in	in	IN
cord-344093-3bniy5b5	157	73	human	human	JJ
cord-344093-3bniy5b5	157	74	bronchial	bronchial	JJ
cord-344093-3bniy5b5	157	75	epithelial	epithelial	JJ
cord-344093-3bniy5b5	157	76	cells	cell	NNS
cord-344093-3bniy5b5	157	77	and	and	CC
cord-344093-3bniy5b5	157	78	in	in	IN
cord-344093-3bniy5b5	157	79	an	an	DT
cord-344093-3bniy5b5	157	80	in	in	IN
cord-344093-3bniy5b5	157	81	vivo	vivo	NN
cord-344093-3bniy5b5	157	82	model	model	NN
cord-344093-3bniy5b5	157	83	of	of	IN
cord-344093-3bniy5b5	157	84	IAV	IAV	NNP
cord-344093-3bniy5b5	157	85	infection	infection	NN
cord-344093-3bniy5b5	157	86	(	(	-LRB-
cord-344093-3bniy5b5	157	87	100	100	CD
cord-344093-3bniy5b5	157	88	,	,	,
cord-344093-3bniy5b5	157	89	101	101	CD
cord-344093-3bniy5b5	157	90	)	)	-RRB-
cord-344093-3bniy5b5	157	91	.	.	.
cord-344093-3bniy5b5	158	1	Alongside	alongside	IN
cord-344093-3bniy5b5	158	2	IAV	IAV	NNP
cord-344093-3bniy5b5	158	3	,	,	,
cord-344093-3bniy5b5	158	4	also	also	RB
cord-344093-3bniy5b5	158	5	in	in	IN
cord-344093-3bniy5b5	158	6	RSV	RSV	NNP
cord-344093-3bniy5b5	158	7	infection	infection	NN
cord-344093-3bniy5b5	158	8	the	the	DT
cord-344093-3bniy5b5	158	9	induction	induction	NN
cord-344093-3bniy5b5	158	10	of	of	IN
cord-344093-3bniy5b5	158	11	high	high	JJ
cord-344093-3bniy5b5	158	12	levels	level	NNS
cord-344093-3bniy5b5	158	13	of	of	IN
cord-344093-3bniy5b5	158	14	pro	pro	JJ
cord-344093-3bniy5b5	158	15	-	-	JJ
cord-344093-3bniy5b5	158	16	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	158	17	cytokines	cytokine	NNS
cord-344093-3bniy5b5	158	18	has	have	VBZ
cord-344093-3bniy5b5	158	19	been	be	VBN
cord-344093-3bniy5b5	158	20	directly	directly	RB
cord-344093-3bniy5b5	158	21	related	relate	VBN
cord-344093-3bniy5b5	158	22	to	to	IN
cord-344093-3bniy5b5	158	23	type	type	NN
cord-344093-3bniy5b5	158	24	IFN	IFN	NNP
cord-344093-3bniy5b5	158	25	,	,	,
cord-344093-3bniy5b5	158	26	as	as	IN
cord-344093-3bniy5b5	158	27	RSV	RSV	NNP
cord-344093-3bniy5b5	158	28	-	-	HYPH
cord-344093-3bniy5b5	158	29	infected	infect	VBN
cord-344093-3bniy5b5	158	30	but	but	CC
cord-344093-3bniy5b5	158	31	IFNAR	IFNAR	NNP
cord-344093-3bniy5b5	158	32	-	-	HYPH
cord-344093-3bniy5b5	158	33	deficient	deficient	JJ
cord-344093-3bniy5b5	158	34	mice	mouse	NNS
cord-344093-3bniy5b5	158	35	presented	present	VBN
cord-344093-3bniy5b5	158	36	with	with	IN
cord-344093-3bniy5b5	158	37	significantly	significantly	RB
cord-344093-3bniy5b5	158	38	diminished	diminish	VBN
cord-344093-3bniy5b5	158	39	pro	pro	JJ
cord-344093-3bniy5b5	158	40	-	-	JJ
cord-344093-3bniy5b5	158	41	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	158	42	cytokine	cytokine	NN
cord-344093-3bniy5b5	158	43	release	release	NN
cord-344093-3bniy5b5	158	44	,	,	,
cord-344093-3bniy5b5	158	45	which	which	WDT
cord-344093-3bniy5b5	158	46	translated	translate	VBD
cord-344093-3bniy5b5	158	47	into	into	IN
cord-344093-3bniy5b5	158	48	an	an	DT
cord-344093-3bniy5b5	158	49	attenuated	attenuated	JJ
cord-344093-3bniy5b5	158	50	disease	disease	NN
cord-344093-3bniy5b5	158	51	course	course	NN
cord-344093-3bniy5b5	158	52	(	(	-LRB-
cord-344093-3bniy5b5	158	53	67	67	CD
cord-344093-3bniy5b5	158	54	)	)	-RRB-
cord-344093-3bniy5b5	158	55	.	.	.
cord-344093-3bniy5b5	159	1	Also	also	RB
cord-344093-3bniy5b5	159	2	in	in	IN
cord-344093-3bniy5b5	159	3	SARS	SARS	NNP
cord-344093-3bniy5b5	159	4	-	-	HYPH
cord-344093-3bniy5b5	159	5	CoV	CoV	NNP
cord-344093-3bniy5b5	159	6	,	,	,
cord-344093-3bniy5b5	159	7	the	the	DT
cord-344093-3bniy5b5	159	8	late	late	JJ
cord-344093-3bniy5b5	159	9	phase	phase	NN
cord-344093-3bniy5b5	159	10	type	type	NN
cord-344093-3bniy5b5	160	1	I	-PRON-	PRP
cord-344093-3bniy5b5	160	2	IFN	IFN	NNP
cord-344093-3bniy5b5	160	3	induction	induction	NN
cord-344093-3bniy5b5	160	4	relates	relate	VBZ
cord-344093-3bniy5b5	160	5	to	to	IN
cord-344093-3bniy5b5	160	6	accumulation	accumulation	NN
cord-344093-3bniy5b5	160	7	of	of	IN
cord-344093-3bniy5b5	160	8	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	160	9	macrophage	macrophage	NN
cord-344093-3bniy5b5	160	10	populations	population	NNS
cord-344093-3bniy5b5	160	11	and	and	CC
cord-344093-3bniy5b5	160	12	elevated	elevated	JJ
cord-344093-3bniy5b5	160	13	lung	lung	NN
cord-344093-3bniy5b5	160	14	cytokine	cytokine	NN
cord-344093-3bniy5b5	160	15	levels	level	NNS
cord-344093-3bniy5b5	160	16	(	(	-LRB-
cord-344093-3bniy5b5	160	17	76	76	CD
cord-344093-3bniy5b5	160	18	)	)	-RRB-
cord-344093-3bniy5b5	160	19	.	.	.
cord-344093-3bniy5b5	161	1	In	in	IN
cord-344093-3bniy5b5	161	2	addition	addition	NN
cord-344093-3bniy5b5	161	3	to	to	IN
cord-344093-3bniy5b5	161	4	antiviral	antiviral	JJ
cord-344093-3bniy5b5	161	5	,	,	,
cord-344093-3bniy5b5	161	6	immunomodulatory	immunomodulatory	NNP
cord-344093-3bniy5b5	161	7	,	,	,
cord-344093-3bniy5b5	161	8	and	and	CC
cord-344093-3bniy5b5	161	9	pro	pro	JJ
cord-344093-3bniy5b5	161	10	-	-	JJ
cord-344093-3bniy5b5	161	11	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	161	12	ISGs	isg	NNS
cord-344093-3bniy5b5	161	13	,	,	,
cord-344093-3bniy5b5	161	14	IFN	IFN	NNP
cord-344093-3bniy5b5	161	15	signaling	signal	VBG
cord-344093-3bniy5b5	161	16	results	result	NNS
cord-344093-3bniy5b5	161	17	in	in	IN
cord-344093-3bniy5b5	161	18	the	the	DT
cord-344093-3bniy5b5	161	19	transcription	transcription	NN
cord-344093-3bniy5b5	161	20	and	and	CC
cord-344093-3bniy5b5	161	21	translation	translation	NN
cord-344093-3bniy5b5	161	22	of	of	IN
cord-344093-3bniy5b5	161	23	cell	cell	NN
cord-344093-3bniy5b5	161	24	death	death	NN
cord-344093-3bniy5b5	161	25	-	-	HYPH
cord-344093-3bniy5b5	161	26	inducing	induce	VBG
cord-344093-3bniy5b5	161	27	ISGs	isg	NNS
cord-344093-3bniy5b5	161	28	.	.	.
cord-344093-3bniy5b5	162	1	In	in	IN
cord-344093-3bniy5b5	162	2	the	the	DT
cord-344093-3bniy5b5	162	3	context	context	NN
cord-344093-3bniy5b5	162	4	of	of	IN
cord-344093-3bniy5b5	162	5	viral	viral	JJ
cord-344093-3bniy5b5	162	6	infection	infection	NN
cord-344093-3bniy5b5	162	7	,	,	,
cord-344093-3bniy5b5	162	8	these	these	DT
cord-344093-3bniy5b5	162	9	factors	factor	NNS
cord-344093-3bniy5b5	162	10	provide	provide	VBP
cord-344093-3bniy5b5	162	11	a	a	DT
cord-344093-3bniy5b5	162	12	mode	mode	NN
cord-344093-3bniy5b5	162	13	to	to	TO
cord-344093-3bniy5b5	162	14	block	block	VB
cord-344093-3bniy5b5	162	15	viral	viral	JJ
cord-344093-3bniy5b5	162	16	spreading	spreading	NN
cord-344093-3bniy5b5	162	17	and	and	CC
cord-344093-3bniy5b5	162	18	reinfection	reinfection	NN
cord-344093-3bniy5b5	162	19	by	by	IN
cord-344093-3bniy5b5	162	20	killing	kill	VBG
cord-344093-3bniy5b5	162	21	those	those	DT
cord-344093-3bniy5b5	162	22	infected	infect	VBN
cord-344093-3bniy5b5	162	23	cells	cell	NNS
cord-344093-3bniy5b5	162	24	,	,	,
cord-344093-3bniy5b5	162	25	in	in	IN
cord-344093-3bniy5b5	162	26	which	which	WDT
cord-344093-3bniy5b5	162	27	the	the	DT
cord-344093-3bniy5b5	162	28	internal	internal	JJ
cord-344093-3bniy5b5	162	29	activation	activation	NN
cord-344093-3bniy5b5	162	30	of	of	IN
cord-344093-3bniy5b5	162	31	antiviral	antiviral	JJ
cord-344093-3bniy5b5	162	32	ISGs	ISGs	NNPS
cord-344093-3bniy5b5	162	33	is	be	VBZ
cord-344093-3bniy5b5	162	34	not	not	RB
cord-344093-3bniy5b5	162	35	sufficient	sufficient	JJ
cord-344093-3bniy5b5	162	36	to	to	TO
cord-344093-3bniy5b5	162	37	restrict	restrict	VB
cord-344093-3bniy5b5	162	38	viral	viral	JJ
cord-344093-3bniy5b5	162	39	replication	replication	NN
cord-344093-3bniy5b5	162	40	.	.	.
cord-344093-3bniy5b5	163	1	Thus	thus	RB
cord-344093-3bniy5b5	163	2	,	,	,
cord-344093-3bniy5b5	163	3	the	the	DT
cord-344093-3bniy5b5	163	4	infected	infected	JJ
cord-344093-3bniy5b5	163	5	cell	cell	NN
cord-344093-3bniy5b5	163	6	is	be	VBZ
cord-344093-3bniy5b5	163	7	sacrificed	sacrifice	VBN
cord-344093-3bniy5b5	163	8	to	to	TO
cord-344093-3bniy5b5	163	9	prevent	prevent	VB
cord-344093-3bniy5b5	163	10	the	the	DT
cord-344093-3bniy5b5	163	11	release	release	NN
cord-344093-3bniy5b5	163	12	of	of	IN
cord-344093-3bniy5b5	163	13	infectious	infectious	JJ
cord-344093-3bniy5b5	163	14	progeny	progeny	NN
cord-344093-3bniy5b5	163	15	virions	virion	NNS
cord-344093-3bniy5b5	163	16	to	to	TO
cord-344093-3bniy5b5	163	17	limit	limit	VB
cord-344093-3bniy5b5	163	18	viral	viral	JJ
cord-344093-3bniy5b5	163	19	spreading	spreading	NN
cord-344093-3bniy5b5	163	20	.	.	.
cord-344093-3bniy5b5	164	1	However	however	RB
cord-344093-3bniy5b5	164	2	,	,	,
cord-344093-3bniy5b5	164	3	especially	especially	RB
cord-344093-3bniy5b5	164	4	in	in	IN
cord-344093-3bniy5b5	164	5	the	the	DT
cord-344093-3bniy5b5	164	6	lung	lung	NN
cord-344093-3bniy5b5	164	7	,	,	,
cord-344093-3bniy5b5	164	8	the	the	DT
cord-344093-3bniy5b5	164	9	disruption	disruption	NN
cord-344093-3bniy5b5	164	10	of	of	IN
cord-344093-3bniy5b5	164	11	the	the	DT
cord-344093-3bniy5b5	164	12	alveolar	alveolar	JJ
cord-344093-3bniy5b5	164	13	epithelial	epithelial	JJ
cord-344093-3bniy5b5	164	14	barrier	barrier	NN
cord-344093-3bniy5b5	164	15	by	by	IN
cord-344093-3bniy5b5	164	16	cell	cell	NN
cord-344093-3bniy5b5	164	17	death	death	NN
cord-344093-3bniy5b5	164	18	of	of	IN
cord-344093-3bniy5b5	164	19	infected	infected	JJ
cord-344093-3bniy5b5	164	20	cells	cell	NNS
cord-344093-3bniy5b5	164	21	,	,	,
cord-344093-3bniy5b5	164	22	but	but	CC
cord-344093-3bniy5b5	164	23	importantly	importantly	RB
cord-344093-3bniy5b5	164	24	also	also	RB
cord-344093-3bniy5b5	164	25	non	non	JJ
cord-344093-3bniy5b5	164	26	-	-	JJ
cord-344093-3bniy5b5	164	27	infected	infected	JJ
cord-344093-3bniy5b5	164	28	bystander	bystander	NN
cord-344093-3bniy5b5	164	29	cells	cell	NNS
cord-344093-3bniy5b5	164	30	induced	induce	VBN
cord-344093-3bniy5b5	164	31	by	by	IN
cord-344093-3bniy5b5	164	32	factors	factor	NNS
cord-344093-3bniy5b5	164	33	such	such	JJ
cord-344093-3bniy5b5	164	34	as	as	IN
cord-344093-3bniy5b5	164	35	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	164	36	,	,	,
cord-344093-3bniy5b5	164	37	significantly	significantly	RB
cord-344093-3bniy5b5	164	38	contributes	contribute	VBZ
cord-344093-3bniy5b5	164	39	to	to	IN
cord-344093-3bniy5b5	164	40	worsened	worsen	VBN
cord-344093-3bniy5b5	164	41	disease	disease	NN
cord-344093-3bniy5b5	164	42	outcomes	outcome	NNS
cord-344093-3bniy5b5	164	43	.	.	.
cord-344093-3bniy5b5	165	1	Controlled	controlled	JJ
cord-344093-3bniy5b5	165	2	cell	cell	NN
cord-344093-3bniy5b5	165	3	death	death	NN
cord-344093-3bniy5b5	165	4	or	or	CC
cord-344093-3bniy5b5	165	5	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	165	6	can	can	MD
cord-344093-3bniy5b5	165	7	be	be	VB
cord-344093-3bniy5b5	165	8	induced	induce	VBN
cord-344093-3bniy5b5	165	9	by	by	IN
cord-344093-3bniy5b5	165	10	intrinsic	intrinsic	JJ
cord-344093-3bniy5b5	165	11	and	and	CC
cord-344093-3bniy5b5	165	12	extrinsic	extrinsic	JJ
cord-344093-3bniy5b5	165	13	signals	signal	NNS
cord-344093-3bniy5b5	165	14	.	.	.
cord-344093-3bniy5b5	166	1	The	the	DT
cord-344093-3bniy5b5	166	2	intrinsic	intrinsic	JJ
cord-344093-3bniy5b5	166	3	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	166	4	pathway	pathway	NN
cord-344093-3bniy5b5	166	5	is	be	VBZ
cord-344093-3bniy5b5	166	6	initiated	initiate	VBN
cord-344093-3bniy5b5	166	7	by	by	IN
cord-344093-3bniy5b5	166	8	diverse	diverse	JJ
cord-344093-3bniy5b5	166	9	intracellular	intracellular	JJ
cord-344093-3bniy5b5	166	10	stimuli	stimulus	NNS
cord-344093-3bniy5b5	166	11	that	that	WDT
cord-344093-3bniy5b5	166	12	influence	influence	VBP
cord-344093-3bniy5b5	166	13	the	the	DT
cord-344093-3bniy5b5	166	14	expression	expression	NN
cord-344093-3bniy5b5	166	15	and	and	CC
cord-344093-3bniy5b5	166	16	activation	activation	NN
cord-344093-3bniy5b5	166	17	of	of	IN
cord-344093-3bniy5b5	166	18	B	b	NN
cord-344093-3bniy5b5	166	19	cell	cell	NN
cord-344093-3bniy5b5	166	20	lymphoma	lymphoma	NN
cord-344093-3bniy5b5	166	21	(	(	-LRB-
cord-344093-3bniy5b5	166	22	Bcl)-2	bcl)-2	NN
cord-344093-3bniy5b5	166	23	family	family	NN
cord-344093-3bniy5b5	166	24	proteins	protein	NNS
cord-344093-3bniy5b5	166	25	that	that	WDT
cord-344093-3bniy5b5	166	26	govern	govern	VBP
cord-344093-3bniy5b5	166	27	the	the	DT
cord-344093-3bniy5b5	166	28	permeabilization	permeabilization	NN
cord-344093-3bniy5b5	166	29	status	status	NN
cord-344093-3bniy5b5	166	30	of	of	IN
cord-344093-3bniy5b5	166	31	the	the	DT
cord-344093-3bniy5b5	166	32	outer	outer	JJ
cord-344093-3bniy5b5	166	33	mitochondrial	mitochondrial	NN
cord-344093-3bniy5b5	166	34	membrane	membrane	NN
cord-344093-3bniy5b5	166	35	.	.	.
cord-344093-3bniy5b5	167	1	Once	once	IN
cord-344093-3bniy5b5	167	2	cytochrome	cytochrome	NN
cord-344093-3bniy5b5	167	3	c	c	NN
cord-344093-3bniy5b5	167	4	is	be	VBZ
cord-344093-3bniy5b5	167	5	released	release	VBN
cord-344093-3bniy5b5	167	6	from	from	IN
cord-344093-3bniy5b5	167	7	the	the	DT
cord-344093-3bniy5b5	167	8	mitochondria	mitochondrion	NNS
cord-344093-3bniy5b5	167	9	,	,	,
cord-344093-3bniy5b5	167	10	it	-PRON-	PRP
cord-344093-3bniy5b5	167	11	binds	bind	VBZ
cord-344093-3bniy5b5	167	12	to	to	IN
cord-344093-3bniy5b5	167	13	the	the	DT
cord-344093-3bniy5b5	167	14	intracellular	intracellular	JJ
cord-344093-3bniy5b5	167	15	adaptor	adaptor	NN
cord-344093-3bniy5b5	167	16	protein	protein	NN
cord-344093-3bniy5b5	167	17	,	,	,
cord-344093-3bniy5b5	167	18	apoptotic	apoptotic	JJ
cord-344093-3bniy5b5	167	19	peptidase	peptidase	NN
cord-344093-3bniy5b5	167	20	activating	activate	VBG
cord-344093-3bniy5b5	167	21	factor	factor	NN
cord-344093-3bniy5b5	167	22	1	1	CD
cord-344093-3bniy5b5	167	23	,	,	,
cord-344093-3bniy5b5	167	24	forming	form	VBG
cord-344093-3bniy5b5	167	25	the	the	DT
cord-344093-3bniy5b5	167	26	so	so	RB
cord-344093-3bniy5b5	167	27	-	-	HYPH
cord-344093-3bniy5b5	167	28	called	call	VBN
cord-344093-3bniy5b5	167	29	apoptosome	apoptosome	NN
cord-344093-3bniy5b5	167	30	that	that	WDT
cord-344093-3bniy5b5	167	31	in	in	IN
cord-344093-3bniy5b5	167	32	turn	turn	NN
cord-344093-3bniy5b5	167	33	recruits	recruit	VBZ
cord-344093-3bniy5b5	167	34	pro	pro	JJ
cord-344093-3bniy5b5	167	35	-	-	JJ
cord-344093-3bniy5b5	167	36	caspase-9	caspase-9	NNP
cord-344093-3bniy5b5	167	37	(	(	-LRB-
cord-344093-3bniy5b5	167	38	102	102	CD
cord-344093-3bniy5b5	167	39	)	)	-RRB-
cord-344093-3bniy5b5	167	40	.	.	.
cord-344093-3bniy5b5	168	1	Caspases	caspase	NNS
cord-344093-3bniy5b5	168	2	(	(	-LRB-
cord-344093-3bniy5b5	168	3	cysteine	cysteine	NN
cord-344093-3bniy5b5	168	4	-	-	HYPH
cord-344093-3bniy5b5	168	5	aspartic	aspartic	JJ
cord-344093-3bniy5b5	168	6	proteases	protease	NNS
cord-344093-3bniy5b5	168	7	)	)	-RRB-
cord-344093-3bniy5b5	168	8	exert	exert	VBP
cord-344093-3bniy5b5	168	9	their	-PRON-	PRP$
cord-344093-3bniy5b5	168	10	action	action	NN
cord-344093-3bniy5b5	168	11	by	by	IN
cord-344093-3bniy5b5	168	12	cleaving	cleave	VBG
cord-344093-3bniy5b5	168	13	other	other	JJ
cord-344093-3bniy5b5	168	14	proteins	protein	NNS
cord-344093-3bniy5b5	168	15	and	and	CC
cord-344093-3bniy5b5	168	16	substrates	substrate	NNS
cord-344093-3bniy5b5	168	17	.	.	.
cord-344093-3bniy5b5	169	1	Herein	herein	RB
cord-344093-3bniy5b5	169	2	,	,	,
cord-344093-3bniy5b5	169	3	initiator	initiator	NN
cord-344093-3bniy5b5	169	4	caspases	caspase	NNS
cord-344093-3bniy5b5	169	5	such	such	JJ
cord-344093-3bniy5b5	169	6	as	as	IN
cord-344093-3bniy5b5	169	7	caspase-8	caspase-8	NNP
cord-344093-3bniy5b5	169	8	and	and	CC
cord-344093-3bniy5b5	169	9	caspase-9	caspase-9	NNP
cord-344093-3bniy5b5	169	10	target	target	NN
cord-344093-3bniy5b5	170	1	other	other	JJ
cord-344093-3bniy5b5	170	2	downstream	downstream	JJ
cord-344093-3bniy5b5	170	3	caspases	caspase	NNS
cord-344093-3bniy5b5	170	4	,	,	,
cord-344093-3bniy5b5	170	5	whereas	whereas	IN
cord-344093-3bniy5b5	170	6	effector	effector	NN
cord-344093-3bniy5b5	170	7	caspases	caspase	NNS
cord-344093-3bniy5b5	170	8	,	,	,
cord-344093-3bniy5b5	170	9	including	include	VBG
cord-344093-3bniy5b5	170	10	caspase-3	caspase-3	NNP
cord-344093-3bniy5b5	170	11	,	,	,
cord-344093-3bniy5b5	170	12	-6	-6	NNP
cord-344093-3bniy5b5	170	13	,	,	,
cord-344093-3bniy5b5	170	14	and	and	CC
cord-344093-3bniy5b5	170	15	-7	-7	NNP
cord-344093-3bniy5b5	170	16	,	,	,
cord-344093-3bniy5b5	170	17	directly	directly	RB
cord-344093-3bniy5b5	170	18	cause	cause	VB
cord-344093-3bniy5b5	170	19	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	170	20	by	by	IN
cord-344093-3bniy5b5	170	21	cleaving	cleave	VBG
cord-344093-3bniy5b5	170	22	and	and	CC
cord-344093-3bniy5b5	170	23	thus	thus	RB
cord-344093-3bniy5b5	170	24	inactivating	inactivate	VBG
cord-344093-3bniy5b5	170	25	or	or	CC
cord-344093-3bniy5b5	170	26	disassembling	disassemble	VBG
cord-344093-3bniy5b5	170	27	a	a	DT
cord-344093-3bniy5b5	170	28	vast	vast	JJ
cord-344093-3bniy5b5	170	29	array	array	NN
cord-344093-3bniy5b5	170	30	of	of	IN
cord-344093-3bniy5b5	170	31	cellular	cellular	JJ
cord-344093-3bniy5b5	170	32	integral	integral	JJ
cord-344093-3bniy5b5	170	33	proteins	protein	NNS
cord-344093-3bniy5b5	170	34	and	and	CC
cord-344093-3bniy5b5	170	35	complexes	complex	NNS
cord-344093-3bniy5b5	170	36	(	(	-LRB-
cord-344093-3bniy5b5	170	37	103	103	CD
cord-344093-3bniy5b5	170	38	)	)	-RRB-
cord-344093-3bniy5b5	170	39	.	.	.
cord-344093-3bniy5b5	171	1	The	the	DT
cord-344093-3bniy5b5	171	2	extrinsic	extrinsic	JJ
cord-344093-3bniy5b5	171	3	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	171	4	pathway	pathway	NN
cord-344093-3bniy5b5	171	5	relies	rely	VBZ
cord-344093-3bniy5b5	171	6	on	on	IN
cord-344093-3bniy5b5	171	7	an	an	DT
cord-344093-3bniy5b5	171	8	extracellular	extracellular	JJ
cord-344093-3bniy5b5	171	9	signal	signal	NN
cord-344093-3bniy5b5	171	10	exerted	exert	VBN
cord-344093-3bniy5b5	171	11	by	by	IN
cord-344093-3bniy5b5	171	12	ligands	ligand	NNS
cord-344093-3bniy5b5	171	13	of	of	IN
cord-344093-3bniy5b5	171	14	the	the	DT
cord-344093-3bniy5b5	171	15	tumor	tumor	NN
cord-344093-3bniy5b5	171	16	necrosis	necrosis	NN
cord-344093-3bniy5b5	171	17	factor	factor	NN
cord-344093-3bniy5b5	171	18	(	(	-LRB-
cord-344093-3bniy5b5	171	19	TNF	TNF	NNP
cord-344093-3bniy5b5	171	20	)	)	-RRB-
cord-344093-3bniy5b5	171	21	receptor	receptor	NN
cord-344093-3bniy5b5	171	22	(	(	-LRB-
cord-344093-3bniy5b5	171	23	TNFR	TNFR	NNP
cord-344093-3bniy5b5	171	24	)	)	-RRB-
cord-344093-3bniy5b5	171	25	superfamily	superfamily	NN
cord-344093-3bniy5b5	171	26	,	,	,
cord-344093-3bniy5b5	171	27	including	include	VBG
cord-344093-3bniy5b5	171	28	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	171	29	,	,	,
cord-344093-3bniy5b5	171	30	TNF	TNF	NNP
cord-344093-3bniy5b5	171	31	-	-	HYPH
cord-344093-3bniy5b5	171	32	α	α	NNP
cord-344093-3bniy5b5	171	33	,	,	,
cord-344093-3bniy5b5	171	34	and	and	CC
cord-344093-3bniy5b5	171	35	Fas	Fas	NNP
cord-344093-3bniy5b5	171	36	ligand	ligand	NN
cord-344093-3bniy5b5	171	37	(	(	-LRB-
cord-344093-3bniy5b5	171	38	FasL	FasL	NNP
cord-344093-3bniy5b5	171	39	)	)	-RRB-
cord-344093-3bniy5b5	171	40	(	(	-LRB-
cord-344093-3bniy5b5	171	41	104	104	CD
cord-344093-3bniy5b5	171	42	)	)	-RRB-
cord-344093-3bniy5b5	171	43	.	.	.
cord-344093-3bniy5b5	172	1	Their	-PRON-	PRP$
cord-344093-3bniy5b5	172	2	ligation	ligation	NN
cord-344093-3bniy5b5	172	3	to	to	IN
cord-344093-3bniy5b5	172	4	their	-PRON-	PRP$
cord-344093-3bniy5b5	172	5	respective	respective	JJ
cord-344093-3bniy5b5	172	6	cell	cell	NN
cord-344093-3bniy5b5	172	7	surface	surface	NN
cord-344093-3bniy5b5	172	8	-	-	HYPH
cord-344093-3bniy5b5	172	9	expressed	express	VBN
cord-344093-3bniy5b5	172	10	death	death	NN
cord-344093-3bniy5b5	172	11	receptors	receptor	NNS
cord-344093-3bniy5b5	172	12	(	(	-LRB-
cord-344093-3bniy5b5	172	13	DR	DR	NNP
cord-344093-3bniy5b5	172	14	)	)	-RRB-
cord-344093-3bniy5b5	172	15	leads	lead	VBZ
cord-344093-3bniy5b5	172	16	via	via	IN
cord-344093-3bniy5b5	172	17	the	the	DT
cord-344093-3bniy5b5	172	18	signal	signal	JJ
cord-344093-3bniy5b5	172	19	transmission	transmission	NN
cord-344093-3bniy5b5	172	20	by	by	IN
cord-344093-3bniy5b5	172	21	Fas	Fas	NNP
cord-344093-3bniy5b5	172	22	-	-	HYPH
cord-344093-3bniy5b5	172	23	associated	associate	VBN
cord-344093-3bniy5b5	172	24	protein	protein	NN
cord-344093-3bniy5b5	172	25	with	with	IN
cord-344093-3bniy5b5	172	26	death	death	NN
cord-344093-3bniy5b5	172	27	domain	domain	NN
cord-344093-3bniy5b5	172	28	(	(	-LRB-
cord-344093-3bniy5b5	172	29	FADD	FADD	NNP
cord-344093-3bniy5b5	172	30	)	)	-RRB-
cord-344093-3bniy5b5	172	31	to	to	IN
cord-344093-3bniy5b5	172	32	the	the	DT
cord-344093-3bniy5b5	172	33	activation	activation	NN
cord-344093-3bniy5b5	172	34	of	of	IN
cord-344093-3bniy5b5	172	35	the	the	DT
cord-344093-3bniy5b5	172	36	initiator	initiator	NN
cord-344093-3bniy5b5	172	37	caspases-8	caspases-8	NNP
cord-344093-3bniy5b5	172	38	or	or	CC
cord-344093-3bniy5b5	172	39	-10	-10	NN
cord-344093-3bniy5b5	172	40	,	,	,
cord-344093-3bniy5b5	172	41	finally	finally	RB
cord-344093-3bniy5b5	172	42	stimulating	stimulate	VBG
cord-344093-3bniy5b5	172	43	effector	effector	NN
cord-344093-3bniy5b5	172	44	caspases	caspase	NNS
cord-344093-3bniy5b5	172	45	including	include	VBG
cord-344093-3bniy5b5	172	46	caspase-3	caspase-3	NNP
cord-344093-3bniy5b5	172	47	(	(	-LRB-
cord-344093-3bniy5b5	172	48	105	105	CD
cord-344093-3bniy5b5	172	49	)	)	-RRB-
cord-344093-3bniy5b5	172	50	.	.	.
cord-344093-3bniy5b5	173	1	To	to	IN
cord-344093-3bniy5b5	173	2	date	date	NN
cord-344093-3bniy5b5	173	3	,	,	,
cord-344093-3bniy5b5	173	4	several	several	JJ
cord-344093-3bniy5b5	173	5	type	type	NN
cord-344093-3bniy5b5	173	6	I	-PRON-	PRP
cord-344093-3bniy5b5	173	7	and	and	CC
cord-344093-3bniy5b5	173	8	type	type	NN
cord-344093-3bniy5b5	173	9	III	III	NNP
cord-344093-3bniy5b5	173	10	IFN	IFN	NNP
cord-344093-3bniy5b5	173	11	-	-	HYPH
cord-344093-3bniy5b5	173	12	induced	induce	VBN
cord-344093-3bniy5b5	173	13	,	,	,
cord-344093-3bniy5b5	173	14	proapoptotic	proapoptotic	JJ
cord-344093-3bniy5b5	173	15	factors	factor	NNS
cord-344093-3bniy5b5	173	16	have	have	VBP
cord-344093-3bniy5b5	173	17	been	be	VBN
cord-344093-3bniy5b5	173	18	identified	identify	VBN
cord-344093-3bniy5b5	173	19	(	(	-LRB-
cord-344093-3bniy5b5	173	20	106	106	CD
cord-344093-3bniy5b5	173	21	)	)	-RRB-
cord-344093-3bniy5b5	173	22	.	.	.
cord-344093-3bniy5b5	174	1	Both	both	CC
cord-344093-3bniy5b5	174	2	caspase-4	caspase-4	NNP
cord-344093-3bniy5b5	174	3	and	and	CC
cord-344093-3bniy5b5	174	4	caspase-8	caspase-8	NNP
cord-344093-3bniy5b5	174	5	have	have	VBP
cord-344093-3bniy5b5	174	6	been	be	VBN
cord-344093-3bniy5b5	174	7	shown	show	VBN
cord-344093-3bniy5b5	174	8	to	to	TO
cord-344093-3bniy5b5	174	9	be	be	VB
cord-344093-3bniy5b5	174	10	upregulated	upregulate	VBN
cord-344093-3bniy5b5	174	11	upon	upon	IN
cord-344093-3bniy5b5	174	12	type	type	NN
cord-344093-3bniy5b5	175	1	I	-PRON-	PRP
cord-344093-3bniy5b5	175	2	IFN	IFN	NNP
cord-344093-3bniy5b5	175	3	signaling	signal	VBG
cord-344093-3bniy5b5	175	4	(	(	-LRB-
cord-344093-3bniy5b5	175	5	4	4	CD
cord-344093-3bniy5b5	175	6	,	,	,
cord-344093-3bniy5b5	175	7	107	107	CD
cord-344093-3bniy5b5	175	8	)	)	-RRB-
cord-344093-3bniy5b5	175	9	;	;	:
cord-344093-3bniy5b5	175	10	caspase-8	caspase-8	NNP
cord-344093-3bniy5b5	175	11	enhances	enhance	VBZ
cord-344093-3bniy5b5	175	12	the	the	DT
cord-344093-3bniy5b5	175	13	FADD	FADD	NNP
cord-344093-3bniy5b5	175	14	-	-	HYPH
cord-344093-3bniy5b5	175	15	driven	drive	VBN
cord-344093-3bniy5b5	175	16	extrinsic	extrinsic	JJ
cord-344093-3bniy5b5	175	17	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	175	18	pathway	pathway	NN
cord-344093-3bniy5b5	175	19	,	,	,
cord-344093-3bniy5b5	175	20	whereas	whereas	IN
cord-344093-3bniy5b5	175	21	the	the	DT
cord-344093-3bniy5b5	175	22	less	less	RBR
cord-344093-3bniy5b5	175	23	-	-	HYPH
cord-344093-3bniy5b5	175	24	studied	study	VBN
cord-344093-3bniy5b5	175	25	caspase-4	caspase-4	NNP
cord-344093-3bniy5b5	175	26	may	may	MD
cord-344093-3bniy5b5	175	27	promote	promote	VB
cord-344093-3bniy5b5	175	28	pro	pro	JJ
cord-344093-3bniy5b5	175	29	-	-	JJ
cord-344093-3bniy5b5	175	30	IL-1β	il-1β	JJ
cord-344093-3bniy5b5	175	31	cleavage	cleavage	NN
cord-344093-3bniy5b5	175	32	and	and	CC
cord-344093-3bniy5b5	175	33	inflammasome	inflammasome	NN
cord-344093-3bniy5b5	175	34	-	-	HYPH
cord-344093-3bniy5b5	175	35	driven	drive	VBN
cord-344093-3bniy5b5	175	36	cell	cell	NN
cord-344093-3bniy5b5	175	37	death	death	NN
cord-344093-3bniy5b5	175	38	(	(	-LRB-
cord-344093-3bniy5b5	175	39	pyroptosis	pyroptosis	NNP
cord-344093-3bniy5b5	175	40	)	)	-RRB-
cord-344093-3bniy5b5	175	41	in	in	IN
cord-344093-3bniy5b5	175	42	macrophages	macrophage	NNS
cord-344093-3bniy5b5	175	43	(	(	-LRB-
cord-344093-3bniy5b5	175	44	108	108	CD
cord-344093-3bniy5b5	175	45	,	,	,
cord-344093-3bniy5b5	175	46	109	109	CD
cord-344093-3bniy5b5	175	47	)	)	-RRB-
cord-344093-3bniy5b5	175	48	.	.	.
cord-344093-3bniy5b5	176	1	Chattopadhyay	Chattopadhyay	NNP
cord-344093-3bniy5b5	176	2	et	et	IN
cord-344093-3bniy5b5	176	3	al	al	NNP
cord-344093-3bniy5b5	176	4	.	.	.
cord-344093-3bniy5b5	177	1	(	(	-LRB-
cord-344093-3bniy5b5	177	2	110	110	CD
cord-344093-3bniy5b5	177	3	)	)	-RRB-
cord-344093-3bniy5b5	177	4	demonstrated	demonstrate	VBD
cord-344093-3bniy5b5	177	5	that	that	IN
cord-344093-3bniy5b5	177	6	Sendai	Sendai	NNP
cord-344093-3bniy5b5	177	7	virus	virus	NN
cord-344093-3bniy5b5	177	8	infection	infection	NN
cord-344093-3bniy5b5	177	9	and	and	CC
cord-344093-3bniy5b5	177	10	polyI	polyI	NNP
cord-344093-3bniy5b5	177	11	:	:	:
cord-344093-3bniy5b5	177	12	C	c	NN
cord-344093-3bniy5b5	177	13	treatment	treatment	NN
cord-344093-3bniy5b5	177	14	resulted	result	VBD
cord-344093-3bniy5b5	177	15	in	in	IN
cord-344093-3bniy5b5	177	16	Bcl-2-associated	Bcl-2-associated	NNP
cord-344093-3bniy5b5	177	17	X	X	NNP
cord-344093-3bniy5b5	177	18	protein	protein	NN
cord-344093-3bniy5b5	177	19	(	(	-LRB-
cord-344093-3bniy5b5	177	20	Bax	Bax	NNP
cord-344093-3bniy5b5	177	21	)	)	-RRB-
cord-344093-3bniy5b5	177	22	activation	activation	NN
cord-344093-3bniy5b5	177	23	and	and	CC
cord-344093-3bniy5b5	177	24	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	177	25	induction	induction	NN
cord-344093-3bniy5b5	177	26	via	via	IN
cord-344093-3bniy5b5	177	27	one	one	CD
cord-344093-3bniy5b5	177	28	of	of	IN
cord-344093-3bniy5b5	177	29	the	the	DT
cord-344093-3bniy5b5	177	30	key	key	JJ
cord-344093-3bniy5b5	177	31	transcription	transcription	NN
cord-344093-3bniy5b5	177	32	factors	factor	NNS
cord-344093-3bniy5b5	177	33	of	of	IN
cord-344093-3bniy5b5	177	34	IFN	IFN	NNP
cord-344093-3bniy5b5	177	35	genes	gene	NNS
cord-344093-3bniy5b5	177	36	,	,	,
cord-344093-3bniy5b5	177	37	IRF3	IRF3	NNP
cord-344093-3bniy5b5	177	38	.	.	.
cord-344093-3bniy5b5	178	1	In	in	IN
cord-344093-3bniy5b5	178	2	addition	addition	NN
cord-344093-3bniy5b5	178	3	IRF5	IRF5	NNP
cord-344093-3bniy5b5	178	4	was	be	VBD
cord-344093-3bniy5b5	178	5	reported	report	VBN
cord-344093-3bniy5b5	178	6	to	to	TO
cord-344093-3bniy5b5	178	7	enhance	enhance	VB
cord-344093-3bniy5b5	178	8	TRAIL	trail	NN
cord-344093-3bniy5b5	178	9	-	-	HYPH
cord-344093-3bniy5b5	178	10	dependent	dependent	JJ
cord-344093-3bniy5b5	178	11	extrinsic	extrinsic	JJ
cord-344093-3bniy5b5	178	12	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	178	13	by	by	IN
cord-344093-3bniy5b5	178	14	nuclear	nuclear	JJ
cord-344093-3bniy5b5	178	15	translocation	translocation	NN
cord-344093-3bniy5b5	178	16	resulting	result	VBG
cord-344093-3bniy5b5	178	17	in	in	IN
cord-344093-3bniy5b5	178	18	the	the	DT
cord-344093-3bniy5b5	178	19	translation	translation	NN
cord-344093-3bniy5b5	178	20	of	of	IN
cord-344093-3bniy5b5	178	21	to	to	IN
cord-344093-3bniy5b5	178	22	date	date	NN
cord-344093-3bniy5b5	178	23	undefined	undefined	JJ
cord-344093-3bniy5b5	178	24	factors	factor	NNS
cord-344093-3bniy5b5	178	25	that	that	WDT
cord-344093-3bniy5b5	178	26	increase	increase	VBP
cord-344093-3bniy5b5	178	27	cell	cell	NN
cord-344093-3bniy5b5	178	28	death	death	NN
cord-344093-3bniy5b5	178	29	upstream	upstream	RB
cord-344093-3bniy5b5	178	30	of	of	IN
cord-344093-3bniy5b5	178	31	caspase-8	caspase-8	NNP
cord-344093-3bniy5b5	178	32	activation	activation	NN
cord-344093-3bniy5b5	178	33	(	(	-LRB-
cord-344093-3bniy5b5	178	34	111	111	CD
cord-344093-3bniy5b5	178	35	)	)	-RRB-
cord-344093-3bniy5b5	178	36	.	.	.
cord-344093-3bniy5b5	179	1	Furthermore	furthermore	RB
cord-344093-3bniy5b5	179	2	,	,	,
cord-344093-3bniy5b5	179	3	both	both	DT
cord-344093-3bniy5b5	179	4	RLRs	rlr	NNS
cord-344093-3bniy5b5	179	5	,	,	,
cord-344093-3bniy5b5	179	6	RIG	rig	NN
cord-344093-3bniy5b5	179	7	-	-	:
cord-344093-3bniy5b5	179	8	I	I	NNP
cord-344093-3bniy5b5	179	9	and	and	CC
cord-344093-3bniy5b5	179	10	MDA-5	MDA-5	NNP
cord-344093-3bniy5b5	179	11	,	,	,
cord-344093-3bniy5b5	179	12	trigger	trigger	VB
cord-344093-3bniy5b5	179	13	the	the	DT
cord-344093-3bniy5b5	179	14	proteins	protein	NNS
cord-344093-3bniy5b5	179	15	Puma	Puma	NNP
cord-344093-3bniy5b5	179	16	and	and	CC
cord-344093-3bniy5b5	179	17	Noxa	Noxa	NNP
cord-344093-3bniy5b5	179	18	that	that	WDT
cord-344093-3bniy5b5	179	19	induce	induce	VBP
cord-344093-3bniy5b5	179	20	Bcl	Bcl	NNP
cord-344093-3bniy5b5	179	21	and	and	CC
cord-344093-3bniy5b5	179	22	The	the	DT
cord-344093-3bniy5b5	179	23	IFN	IFN	NNP
cord-344093-3bniy5b5	179	24	/	/	SYM
cord-344093-3bniy5b5	179	25	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	180	1	Signaling	signal	VBG
cord-344093-3bniy5b5	180	2	Axis	Axis	NNP
cord-344093-3bniy5b5	180	3	Frontiers	Frontiers	NNPS
cord-344093-3bniy5b5	180	4	in	in	IN
cord-344093-3bniy5b5	180	5	Immunology	Immunology	NNP
cord-344093-3bniy5b5	180	6	|	|	NNP
cord-344093-3bniy5b5	181	1	www.frontiersin.org	www.frontiersin.org	IN
cord-344093-3bniy5b5	181	2	March	March	NNP
cord-344093-3bniy5b5	181	3	2017	2017	CD
cord-344093-3bniy5b5	181	4	|	|	NNP
cord-344093-3bniy5b5	181	5	Volume	Volume	NNP
cord-344093-3bniy5b5	181	6	8	8	CD
cord-344093-3bniy5b5	181	7	|	|	NNP
cord-344093-3bniy5b5	181	8	Article	Article	NNP
cord-344093-3bniy5b5	181	9	313	313	CD
cord-344093-3bniy5b5	181	10	thus	thus	RB
cord-344093-3bniy5b5	181	11	activate	activate	VBP
cord-344093-3bniy5b5	181	12	the	the	DT
cord-344093-3bniy5b5	181	13	intrinsic	intrinsic	JJ
cord-344093-3bniy5b5	181	14	mitochondrial	mitochondrial	JJ
cord-344093-3bniy5b5	181	15	apoptotic	apoptotic	JJ
cord-344093-3bniy5b5	181	16	cascade	cascade	NN
cord-344093-3bniy5b5	181	17	(	(	-LRB-
cord-344093-3bniy5b5	181	18	112	112	CD
cord-344093-3bniy5b5	181	19	)	)	-RRB-
cord-344093-3bniy5b5	181	20	.	.	.
cord-344093-3bniy5b5	182	1	Also	also	RB
cord-344093-3bniy5b5	182	2	,	,	,
cord-344093-3bniy5b5	182	3	PKR	PKR	NNP
cord-344093-3bniy5b5	182	4	influences	influence	VBZ
cord-344093-3bniy5b5	182	5	a	a	DT
cord-344093-3bniy5b5	182	6	cell	cell	NN
cord-344093-3bniy5b5	182	7	's	's	POS
cord-344093-3bniy5b5	182	8	susceptibility	susceptibility	NN
cord-344093-3bniy5b5	182	9	to	to	IN
cord-344093-3bniy5b5	182	10	apoptotic	apoptotic	JJ
cord-344093-3bniy5b5	182	11	signals	signal	NNS
cord-344093-3bniy5b5	182	12	,	,	,
cord-344093-3bniy5b5	182	13	as	as	IN
cord-344093-3bniy5b5	182	14	it	-PRON-	PRP
cord-344093-3bniy5b5	182	15	was	be	VBD
cord-344093-3bniy5b5	182	16	demonstrated	demonstrate	VBN
cord-344093-3bniy5b5	182	17	to	to	TO
cord-344093-3bniy5b5	182	18	sensitize	sensitize	VB
cord-344093-3bniy5b5	182	19	to	to	IN
cord-344093-3bniy5b5	182	20	the	the	DT
cord-344093-3bniy5b5	182	21	FADD	FADD	NNP
cord-344093-3bniy5b5	182	22	/	/	SYM
cord-344093-3bniy5b5	182	23	caspase-8	caspase-8	NNP
cord-344093-3bniy5b5	182	24	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	182	25	pathway	pathway	NN
cord-344093-3bniy5b5	182	26	upon	upon	IN
cord-344093-3bniy5b5	182	27	type	type	NN
cord-344093-3bniy5b5	183	1	I	-PRON-	PRP
cord-344093-3bniy5b5	183	2	IFN	IFN	NNP
cord-344093-3bniy5b5	183	3	signaling	signal	VBG
cord-344093-3bniy5b5	183	4	after	after	IN
cord-344093-3bniy5b5	183	5	challenge	challenge	NN
cord-344093-3bniy5b5	183	6	with	with	IN
cord-344093-3bniy5b5	183	7	IAV	IAV	NNP
cord-344093-3bniy5b5	183	8	or	or	CC
cord-344093-3bniy5b5	183	9	dsRNA	dsrna	NN
cord-344093-3bniy5b5	183	10	(	(	-LRB-
cord-344093-3bniy5b5	183	11	4	4	CD
cord-344093-3bniy5b5	183	12	)	)	-RRB-
cord-344093-3bniy5b5	183	13	and	and	CC
cord-344093-3bniy5b5	183	14	the	the	DT
cord-344093-3bniy5b5	183	15	OAS	OAS	NNP
cord-344093-3bniy5b5	183	16	-	-	HYPH
cord-344093-3bniy5b5	183	17	RNAseL	RNAseL	NNP
cord-344093-3bniy5b5	183	18	system	system	NN
cord-344093-3bniy5b5	183	19	has	have	VBZ
cord-344093-3bniy5b5	183	20	been	be	VBN
cord-344093-3bniy5b5	183	21	suggested	suggest	VBN
cord-344093-3bniy5b5	183	22	to	to	TO
cord-344093-3bniy5b5	183	23	contribute	contribute	VB
cord-344093-3bniy5b5	183	24	to	to	IN
cord-344093-3bniy5b5	183	25	IFN	IFN	NNP
cord-344093-3bniy5b5	183	26	-	-	HYPH
cord-344093-3bniy5b5	183	27	α	α	NN
cord-344093-3bniy5b5	183	28	-	-	HYPH
cord-344093-3bniy5b5	183	29	related	relate	VBN
cord-344093-3bniy5b5	183	30	cell	cell	NN
cord-344093-3bniy5b5	183	31	death	death	NN
cord-344093-3bniy5b5	183	32	induction	induction	NN
cord-344093-3bniy5b5	183	33	,	,	,
cord-344093-3bniy5b5	183	34	but	but	CC
cord-344093-3bniy5b5	183	35	the	the	DT
cord-344093-3bniy5b5	183	36	exact	exact	JJ
cord-344093-3bniy5b5	183	37	mechanisms	mechanism	NNS
cord-344093-3bniy5b5	183	38	remain	remain	VBP
cord-344093-3bniy5b5	183	39	to	to	TO
cord-344093-3bniy5b5	183	40	be	be	VB
cord-344093-3bniy5b5	183	41	elucidated	elucidate	VBN
cord-344093-3bniy5b5	183	42	(	(	-LRB-
cord-344093-3bniy5b5	183	43	113	113	CD
cord-344093-3bniy5b5	183	44	)	)	-RRB-
cord-344093-3bniy5b5	183	45	.	.	.
cord-344093-3bniy5b5	184	1	Finally	finally	RB
cord-344093-3bniy5b5	184	2	,	,	,
cord-344093-3bniy5b5	184	3	also	also	RB
cord-344093-3bniy5b5	184	4	two	two	CD
cord-344093-3bniy5b5	184	5	classical	classical	JJ
cord-344093-3bniy5b5	184	6	initiators	initiator	NNS
cord-344093-3bniy5b5	184	7	of	of	IN
cord-344093-3bniy5b5	184	8	the	the	DT
cord-344093-3bniy5b5	184	9	extrinsic	extrinsic	JJ
cord-344093-3bniy5b5	184	10	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	184	11	cascade	cascade	NN
cord-344093-3bniy5b5	184	12	are	be	VBP
cord-344093-3bniy5b5	184	13	induced	induce	VBN
cord-344093-3bniy5b5	184	14	as	as	IN
cord-344093-3bniy5b5	184	15	ISGs	isg	NNS
cord-344093-3bniy5b5	184	16	.	.	.
cord-344093-3bniy5b5	185	1	Both	both	DT
cord-344093-3bniy5b5	185	2	FasL	FasL	NNP
cord-344093-3bniy5b5	185	3	and	and	CC
cord-344093-3bniy5b5	185	4	its	-PRON-	PRP$
cord-344093-3bniy5b5	185	5	receptor	receptor	NN
cord-344093-3bniy5b5	185	6	Fas	Fas	NNP
cord-344093-3bniy5b5	185	7	are	be	VBP
cord-344093-3bniy5b5	185	8	upregulated	upregulate	VBN
cord-344093-3bniy5b5	185	9	on	on	IN
cord-344093-3bniy5b5	185	10	mRNA	mrna	NN
cord-344093-3bniy5b5	185	11	levels	level	NNS
cord-344093-3bniy5b5	185	12	by	by	IN
cord-344093-3bniy5b5	185	13	IFN	IFN	NNP
cord-344093-3bniy5b5	185	14	-	-	HYPH
cord-344093-3bniy5b5	185	15	α	α	NNP
cord-344093-3bniy5b5	185	16	(	(	-LRB-
cord-344093-3bniy5b5	185	17	114	114	CD
cord-344093-3bniy5b5	185	18	)	)	-RRB-
cord-344093-3bniy5b5	185	19	,	,	,
cord-344093-3bniy5b5	185	20	and	and	CC
cord-344093-3bniy5b5	185	21	FasL	FasL	NNP
cord-344093-3bniy5b5	185	22	was	be	VBD
cord-344093-3bniy5b5	185	23	reported	report	VBN
cord-344093-3bniy5b5	185	24	to	to	TO
cord-344093-3bniy5b5	185	25	be	be	VB
cord-344093-3bniy5b5	185	26	induced	induce	VBN
cord-344093-3bniy5b5	185	27	by	by	IN
cord-344093-3bniy5b5	185	28	type	type	NN
cord-344093-3bniy5b5	186	1	I	-PRON-	PRP
cord-344093-3bniy5b5	186	2	IFN	IFN	NNP
cord-344093-3bniy5b5	186	3	in	in	IN
cord-344093-3bniy5b5	186	4	IAV	IAV	NNP
cord-344093-3bniy5b5	186	5	infection	infection	NN
cord-344093-3bniy5b5	186	6	in	in	IN
cord-344093-3bniy5b5	186	7	the	the	DT
cord-344093-3bniy5b5	186	8	murine	murine	JJ
cord-344093-3bniy5b5	186	9	lung	lung	NN
cord-344093-3bniy5b5	186	10	in	in	IN
cord-344093-3bniy5b5	186	11	vivo	vivo	NNP
cord-344093-3bniy5b5	186	12	(	(	-LRB-
cord-344093-3bniy5b5	186	13	115	115	CD
cord-344093-3bniy5b5	186	14	)	)	-RRB-
cord-344093-3bniy5b5	186	15	.	.	.
cord-344093-3bniy5b5	187	1	Also	also	RB
cord-344093-3bniy5b5	187	2	,	,	,
cord-344093-3bniy5b5	187	3	the	the	DT
cord-344093-3bniy5b5	187	4	proapoptotic	proapoptotic	JJ
cord-344093-3bniy5b5	187	5	factor	factor	NN
cord-344093-3bniy5b5	187	6	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	187	7	(	(	-LRB-
cord-344093-3bniy5b5	187	8	or	or	CC
cord-344093-3bniy5b5	187	9	TNFSF10	TNFSF10	NNP
cord-344093-3bniy5b5	187	10	,	,	,
cord-344093-3bniy5b5	187	11	Apo2L	Apo2L	NNS
cord-344093-3bniy5b5	187	12	)	)	-RRB-
cord-344093-3bniy5b5	187	13	is	be	VBZ
cord-344093-3bniy5b5	187	14	induced	induce	VBN
cord-344093-3bniy5b5	187	15	by	by	IN
cord-344093-3bniy5b5	187	16	IFN	IFN	NNP
cord-344093-3bniy5b5	187	17	-	-	HYPH
cord-344093-3bniy5b5	187	18	mediated	mediate	VBN
cord-344093-3bniy5b5	187	19	and	and	CC
cord-344093-3bniy5b5	187	20	ISGF3-executed	isgf3-executed	CD
cord-344093-3bniy5b5	187	21	transcriptional	transcriptional	JJ
cord-344093-3bniy5b5	187	22	activation	activation	NN
cord-344093-3bniy5b5	187	23	,	,	,
cord-344093-3bniy5b5	187	24	as	as	IN
cord-344093-3bniy5b5	187	25	has	have	VBZ
cord-344093-3bniy5b5	187	26	been	be	VBN
cord-344093-3bniy5b5	187	27	shown	show	VBN
cord-344093-3bniy5b5	187	28	by	by	IN
cord-344093-3bniy5b5	187	29	Sato	Sato	NNP
cord-344093-3bniy5b5	187	30	et	et	FW
cord-344093-3bniy5b5	187	31	al	al	NNP
cord-344093-3bniy5b5	187	32	.	.	.
cord-344093-3bniy5b5	188	1	(	(	-LRB-
cord-344093-3bniy5b5	188	2	116	116	CD
cord-344093-3bniy5b5	188	3	)	)	-RRB-
cord-344093-3bniy5b5	188	4	,	,	,
cord-344093-3bniy5b5	188	5	who	who	WP
cord-344093-3bniy5b5	188	6	revealed	reveal	VBD
cord-344093-3bniy5b5	188	7	the	the	DT
cord-344093-3bniy5b5	188	8	presence	presence	NN
cord-344093-3bniy5b5	188	9	of	of	IN
cord-344093-3bniy5b5	188	10	the	the	DT
cord-344093-3bniy5b5	188	11	ISRE	ISRE	NNP
cord-344093-3bniy5b5	188	12	sequence	sequence	NN
cord-344093-3bniy5b5	188	13	within	within	IN
cord-344093-3bniy5b5	188	14	the	the	DT
cord-344093-3bniy5b5	188	15	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	188	16	promoter	promoter	NN
cord-344093-3bniy5b5	188	17	region	region	NN
cord-344093-3bniy5b5	188	18	(	(	-LRB-
cord-344093-3bniy5b5	188	19	116	116	CD
cord-344093-3bniy5b5	188	20	)	)	-RRB-
cord-344093-3bniy5b5	188	21	.	.	.
cord-344093-3bniy5b5	189	1	In	in	IN
cord-344093-3bniy5b5	189	2	IAV	IAV	NNP
cord-344093-3bniy5b5	189	3	infection	infection	NN
cord-344093-3bniy5b5	189	4	,	,	,
cord-344093-3bniy5b5	189	5	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	189	6	is	be	VBZ
cord-344093-3bniy5b5	189	7	released	release	VBN
cord-344093-3bniy5b5	189	8	in	in	IN
cord-344093-3bniy5b5	189	9	high	high	JJ
cord-344093-3bniy5b5	189	10	amounts	amount	NNS
cord-344093-3bniy5b5	189	11	from	from	IN
cord-344093-3bniy5b5	189	12	infected	infected	JJ
cord-344093-3bniy5b5	189	13	alveolar	alveolar	NN
cord-344093-3bniy5b5	189	14	macrophages	macrophage	NNS
cord-344093-3bniy5b5	189	15	depending	depend	VBG
cord-344093-3bniy5b5	189	16	on	on	IN
cord-344093-3bniy5b5	189	17	a	a	DT
cord-344093-3bniy5b5	189	18	PKR	PKR	NNP
cord-344093-3bniy5b5	189	19	-	-	:
cord-344093-3bniy5b5	189	20	and	and	CC
cord-344093-3bniy5b5	189	21	IFN	IFN	NNP
cord-344093-3bniy5b5	189	22	-	-	HYPH
cord-344093-3bniy5b5	189	23	β	β	NN
cord-344093-3bniy5b5	189	24	-	-	HYPH
cord-344093-3bniy5b5	189	25	driven	drive	VBN
cord-344093-3bniy5b5	189	26	autocrine	autocrine	NN
cord-344093-3bniy5b5	189	27	signaling	signaling	NN
cord-344093-3bniy5b5	189	28	loop	loop	NN
cord-344093-3bniy5b5	189	29	.	.	.
cord-344093-3bniy5b5	190	1	Binding	bind	VBG
cord-344093-3bniy5b5	190	2	of	of	IN
cord-344093-3bniy5b5	190	3	IFN	IFN	NNP
cord-344093-3bniy5b5	190	4	-	-	HYPH
cord-344093-3bniy5b5	190	5	β	β	NNP
cord-344093-3bniy5b5	190	6	to	to	IN
cord-344093-3bniy5b5	190	7	macrophageexpressed	macrophageexpresse	VBN
cord-344093-3bniy5b5	190	8	IFNAR	IFNAR	NNP
cord-344093-3bniy5b5	190	9	activates	activate	VBZ
cord-344093-3bniy5b5	190	10	a	a	DT
cord-344093-3bniy5b5	190	11	JAK	JAK	NNP
cord-344093-3bniy5b5	190	12	/	/	SYM
cord-344093-3bniy5b5	190	13	STAT	stat	NN
cord-344093-3bniy5b5	190	14	-	-	HYPH
cord-344093-3bniy5b5	190	15	dependent	dependent	JJ
cord-344093-3bniy5b5	190	16	release	release	NN
cord-344093-3bniy5b5	190	17	of	of	IN
cord-344093-3bniy5b5	190	18	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	190	19	,	,	,
cord-344093-3bniy5b5	190	20	which	which	WDT
cord-344093-3bniy5b5	190	21	then	then	RB
cord-344093-3bniy5b5	190	22	acts	act	VBZ
cord-344093-3bniy5b5	190	23	through	through	IN
cord-344093-3bniy5b5	190	24	its	-PRON-	PRP$
cord-344093-3bniy5b5	190	25	receptor	receptor	NN
cord-344093-3bniy5b5	190	26	DR5	DR5	NNP
cord-344093-3bniy5b5	190	27	on	on	IN
cord-344093-3bniy5b5	190	28	the	the	DT
cord-344093-3bniy5b5	190	29	alveolar	alveolar	JJ
cord-344093-3bniy5b5	190	30	epithelial	epithelial	JJ
cord-344093-3bniy5b5	190	31	cells	cell	NNS
cord-344093-3bniy5b5	190	32	(	(	-LRB-
cord-344093-3bniy5b5	190	33	5	5	CD
cord-344093-3bniy5b5	190	34	,	,	,
cord-344093-3bniy5b5	190	35	10	10	CD
cord-344093-3bniy5b5	190	36	)	)	-RRB-
cord-344093-3bniy5b5	190	37	.	.	.
cord-344093-3bniy5b5	191	1	However	however	RB
cord-344093-3bniy5b5	191	2	,	,	,
cord-344093-3bniy5b5	191	3	certain	certain	JJ
cord-344093-3bniy5b5	191	4	prerequisites	prerequisite	NNS
cord-344093-3bniy5b5	191	5	may	may	MD
cord-344093-3bniy5b5	191	6	decrease	decrease	VB
cord-344093-3bniy5b5	191	7	the	the	DT
cord-344093-3bniy5b5	191	8	ability	ability	NN
cord-344093-3bniy5b5	191	9	of	of	IN
cord-344093-3bniy5b5	191	10	a	a	DT
cord-344093-3bniy5b5	191	11	cell	cell	NN
cord-344093-3bniy5b5	191	12	to	to	TO
cord-344093-3bniy5b5	191	13	undergo	undergo	VB
cord-344093-3bniy5b5	191	14	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	191	15	,	,	,
cord-344093-3bniy5b5	191	16	including	include	VBG
cord-344093-3bniy5b5	191	17	a	a	DT
cord-344093-3bniy5b5	191	18	shortage	shortage	NN
cord-344093-3bniy5b5	191	19	in	in	IN
cord-344093-3bniy5b5	191	20	pro	pro	JJ
cord-344093-3bniy5b5	191	21	-	-	JJ
cord-344093-3bniy5b5	191	22	caspase-8	caspase-8	JJ
cord-344093-3bniy5b5	191	23	availability	availability	NN
cord-344093-3bniy5b5	191	24	,	,	,
cord-344093-3bniy5b5	191	25	expression	expression	NN
cord-344093-3bniy5b5	191	26	of	of	IN
cord-344093-3bniy5b5	191	27	cellular	cellular	JJ
cord-344093-3bniy5b5	191	28	FADD	FADD	NNP
cord-344093-3bniy5b5	191	29	-	-	HYPH
cord-344093-3bniy5b5	191	30	like	like	JJ
cord-344093-3bniy5b5	191	31	IL-1β	il-1β	RB
cord-344093-3bniy5b5	191	32	-	-	HYPH
cord-344093-3bniy5b5	191	33	converting	convert	VBG
cord-344093-3bniy5b5	191	34	enzyme	enzyme	NN
cord-344093-3bniy5b5	191	35	-	-	HYPH
cord-344093-3bniy5b5	191	36	inhibitory	inhibitory	JJ
cord-344093-3bniy5b5	191	37	proteins	protein	NNS
cord-344093-3bniy5b5	191	38	(	(	-LRB-
cord-344093-3bniy5b5	191	39	c	c	NN
cord-344093-3bniy5b5	191	40	-	-	HYPH
cord-344093-3bniy5b5	191	41	FLIPs	flip	NNS
cord-344093-3bniy5b5	191	42	)	)	-RRB-
cord-344093-3bniy5b5	191	43	that	that	WDT
cord-344093-3bniy5b5	191	44	block	block	VBP
cord-344093-3bniy5b5	191	45	FADD	FADD	NNP
cord-344093-3bniy5b5	191	46	-	-	HYPH
cord-344093-3bniy5b5	191	47	driven	drive	VBN
cord-344093-3bniy5b5	191	48	caspase	caspase	NN
cord-344093-3bniy5b5	191	49	activation	activation	NN
cord-344093-3bniy5b5	191	50	,	,	,
cord-344093-3bniy5b5	191	51	inactivation	inactivation	NN
cord-344093-3bniy5b5	191	52	,	,	,
cord-344093-3bniy5b5	191	53	or	or	CC
cord-344093-3bniy5b5	191	54	degradation	degradation	NN
cord-344093-3bniy5b5	191	55	of	of	IN
cord-344093-3bniy5b5	191	56	FADD	FADD	NNP
cord-344093-3bniy5b5	191	57	itself	-PRON-	PRP
cord-344093-3bniy5b5	191	58	,	,	,
cord-344093-3bniy5b5	191	59	or	or	CC
cord-344093-3bniy5b5	191	60	expression	expression	NN
cord-344093-3bniy5b5	191	61	of	of	IN
cord-344093-3bniy5b5	191	62	CYLD	CYLD	NNP
cord-344093-3bniy5b5	191	63	,	,	,
cord-344093-3bniy5b5	191	64	which	which	WDT
cord-344093-3bniy5b5	191	65	acts	act	VBZ
cord-344093-3bniy5b5	191	66	as	as	IN
cord-344093-3bniy5b5	191	67	a	a	DT
cord-344093-3bniy5b5	191	68	receptor	receptor	NN
cord-344093-3bniy5b5	191	69	-	-	HYPH
cord-344093-3bniy5b5	191	70	interacting	interact	VBG
cord-344093-3bniy5b5	191	71	serine	serine	NN
cord-344093-3bniy5b5	191	72	/	/	SYM
cord-344093-3bniy5b5	191	73	threonine	threonine	NN
cord-344093-3bniy5b5	191	74	-	-	HYPH
cord-344093-3bniy5b5	191	75	protein	protein	NN
cord-344093-3bniy5b5	191	76	(	(	-LRB-
cord-344093-3bniy5b5	191	77	RIP)1	rip)1	IN
cord-344093-3bniy5b5	191	78	kinase	kinase	FW
cord-344093-3bniy5b5	191	79	de	de	JJ
cord-344093-3bniy5b5	191	80	-	-	HYPH
cord-344093-3bniy5b5	191	81	ubiquitinase	ubiquitinase	NNP
cord-344093-3bniy5b5	191	82	and	and	CC
cord-344093-3bniy5b5	191	83	thus	thus	RB
cord-344093-3bniy5b5	191	84	stabilizes	stabilize	VBZ
cord-344093-3bniy5b5	191	85	RIP1	RIP1	NNP
cord-344093-3bniy5b5	191	86	.	.	.
cord-344093-3bniy5b5	192	1	However	however	RB
cord-344093-3bniy5b5	192	2	,	,	,
cord-344093-3bniy5b5	192	3	in	in	IN
cord-344093-3bniy5b5	192	4	these	these	DT
cord-344093-3bniy5b5	192	5	cases	case	NNS
cord-344093-3bniy5b5	192	6	IFN	IFN	NNP
cord-344093-3bniy5b5	192	7	signaling	signal	VBG
cord-344093-3bniy5b5	192	8	can	can	MD
cord-344093-3bniy5b5	192	9	still	still	RB
cord-344093-3bniy5b5	192	10	promote	promote	VB
cord-344093-3bniy5b5	192	11	a	a	DT
cord-344093-3bniy5b5	192	12	caspase	caspase	NN
cord-344093-3bniy5b5	192	13	-	-	HYPH
cord-344093-3bniy5b5	192	14	independent	independent	JJ
cord-344093-3bniy5b5	192	15	,	,	,
cord-344093-3bniy5b5	192	16	programmed	program	VBD
cord-344093-3bniy5b5	192	17	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	192	18	cell	cell	NN
cord-344093-3bniy5b5	192	19	death	death	NN
cord-344093-3bniy5b5	192	20	by	by	IN
cord-344093-3bniy5b5	192	21	activating	activate	VBG
cord-344093-3bniy5b5	192	22	the	the	DT
cord-344093-3bniy5b5	192	23	necroptosis	necroptosis	NNP
cord-344093-3bniy5b5	192	24	pathway	pathway	NN
cord-344093-3bniy5b5	192	25	(	(	-LRB-
cord-344093-3bniy5b5	192	26	117	117	CD
cord-344093-3bniy5b5	192	27	,	,	,
cord-344093-3bniy5b5	192	28	118	118	CD
cord-344093-3bniy5b5	192	29	)	)	-RRB-
cord-344093-3bniy5b5	192	30	.	.	.
cord-344093-3bniy5b5	193	1	Necroptosis	Necroptosis	NNP
cord-344093-3bniy5b5	193	2	is	be	VBZ
cord-344093-3bniy5b5	193	3	induced	induce	VBN
cord-344093-3bniy5b5	193	4	by	by	IN
cord-344093-3bniy5b5	193	5	a	a	DT
cord-344093-3bniy5b5	193	6	complex	complex	JJ
cord-344093-3bniy5b5	193	7	formation	formation	NN
cord-344093-3bniy5b5	193	8	by	by	IN
cord-344093-3bniy5b5	193	9	RIP1	RIP1	NNP
cord-344093-3bniy5b5	193	10	and	and	CC
cord-344093-3bniy5b5	193	11	RIP3	RIP3	NNP
cord-344093-3bniy5b5	193	12	kinases	kinase	NNS
cord-344093-3bniy5b5	193	13	that	that	WDT
cord-344093-3bniy5b5	193	14	activate	activate	VBP
cord-344093-3bniy5b5	193	15	both	both	DT
cord-344093-3bniy5b5	193	16	poly	poly	JJ
cord-344093-3bniy5b5	193	17	-	-	HYPH
cord-344093-3bniy5b5	193	18	ADP	adp	NN
cord-344093-3bniy5b5	193	19	-	-	HYPH
cord-344093-3bniy5b5	193	20	ribose	ribose	NN
cord-344093-3bniy5b5	193	21	(	(	-LRB-
cord-344093-3bniy5b5	193	22	PAR	PAR	NNP
cord-344093-3bniy5b5	193	23	)	)	-RRB-
cord-344093-3bniy5b5	193	24	polymerase	polymerase	NN
cord-344093-3bniy5b5	193	25	1	1	CD
cord-344093-3bniy5b5	193	26	(	(	-LRB-
cord-344093-3bniy5b5	193	27	PARP-1	PARP-1	NNS
cord-344093-3bniy5b5	193	28	)	)	-RRB-
cord-344093-3bniy5b5	193	29	and/or	and/or	CC
cord-344093-3bniy5b5	194	1	mixed	mixed	JJ
cord-344093-3bniy5b5	194	2	lineage	lineage	NN
cord-344093-3bniy5b5	194	3	kinase	kinase	NN
cord-344093-3bniy5b5	194	4	domain	domain	NN
cord-344093-3bniy5b5	194	5	-	-	HYPH
cord-344093-3bniy5b5	194	6	like	like	JJ
cord-344093-3bniy5b5	194	7	(	(	-LRB-
cord-344093-3bniy5b5	194	8	MLKL	MLKL	NNP
cord-344093-3bniy5b5	194	9	)	)	-RRB-
cord-344093-3bniy5b5	194	10	,	,	.
cord-344093-3bniy5b5	195	1	leading	lead	VBG
cord-344093-3bniy5b5	195	2	to	to	IN
cord-344093-3bniy5b5	195	3	ATP	ATP	NNP
cord-344093-3bniy5b5	195	4	depletion	depletion	NN
cord-344093-3bniy5b5	195	5	,	,	,
cord-344093-3bniy5b5	195	6	calpain	calpain	NNP
cord-344093-3bniy5b5	195	7	activation	activation	NN
cord-344093-3bniy5b5	195	8	,	,	,
cord-344093-3bniy5b5	195	9	PAR	PAR	NNP
cord-344093-3bniy5b5	195	10	polymer	polymer	NN
cord-344093-3bniy5b5	195	11	accumulation	accumulation	NN
cord-344093-3bniy5b5	195	12	or	or	CC
cord-344093-3bniy5b5	195	13	cell	cell	NN
cord-344093-3bniy5b5	195	14	membrane	membrane	NN
cord-344093-3bniy5b5	195	15	permeabilization	permeabilization	NN
cord-344093-3bniy5b5	195	16	,	,	,
cord-344093-3bniy5b5	195	17	and	and	CC
cord-344093-3bniy5b5	195	18	release	release	NN
cord-344093-3bniy5b5	195	19	of	of	IN
cord-344093-3bniy5b5	195	20	damage	damage	NN
cord-344093-3bniy5b5	195	21	-	-	HYPH
cord-344093-3bniy5b5	195	22	associated	associate	VBN
cord-344093-3bniy5b5	195	23	molecular	molecular	JJ
cord-344093-3bniy5b5	195	24	patterns	pattern	NNS
cord-344093-3bniy5b5	195	25	,	,	,
cord-344093-3bniy5b5	195	26	respectively	respectively	RB
cord-344093-3bniy5b5	195	27	[	[	-LRB-
cord-344093-3bniy5b5	195	28	reviewed	review	VBN
cord-344093-3bniy5b5	195	29	in	in	IN
cord-344093-3bniy5b5	195	30	Ref	Ref	NNP
cord-344093-3bniy5b5	195	31	.	.	.
cord-344093-3bniy5b5	196	1	(	(	-LRB-
cord-344093-3bniy5b5	196	2	119	119	CD
cord-344093-3bniy5b5	196	3	,	,	,
cord-344093-3bniy5b5	196	4	120	120	CD
cord-344093-3bniy5b5	196	5	)	)	-RRB-
cord-344093-3bniy5b5	196	6	]	]	-RRB-
cord-344093-3bniy5b5	196	7	.	.	.
cord-344093-3bniy5b5	197	1	Both	both	CC
cord-344093-3bniy5b5	197	2	a	a	DT
cord-344093-3bniy5b5	197	3	type	type	NN
cord-344093-3bniy5b5	198	1	I	-PRON-	PRP
cord-344093-3bniy5b5	198	2	IFN	IFN	NNP
cord-344093-3bniy5b5	198	3	-	-	HYPH
cord-344093-3bniy5b5	198	4	dependent	dependent	JJ
cord-344093-3bniy5b5	198	5	JAK	JAK	NNP
cord-344093-3bniy5b5	198	6	/	/	SYM
cord-344093-3bniy5b5	198	7	STAT	stat	NN
cord-344093-3bniy5b5	198	8	-	-	HYPH
cord-344093-3bniy5b5	198	9	driven	drive	VBN
cord-344093-3bniy5b5	198	10	activation	activation	NN
cord-344093-3bniy5b5	198	11	of	of	IN
cord-344093-3bniy5b5	198	12	PKR	PKR	NNP
cord-344093-3bniy5b5	198	13	as	as	RB
cord-344093-3bniy5b5	198	14	well	well	RB
cord-344093-3bniy5b5	198	15	as	as	IN
cord-344093-3bniy5b5	198	16	signaling	signal	VBG
cord-344093-3bniy5b5	198	17	by	by	IN
cord-344093-3bniy5b5	198	18	the	the	DT
cord-344093-3bniy5b5	198	19	PRR	PRR	NNP
cord-344093-3bniy5b5	198	20	DAI	DAI	NNP
cord-344093-3bniy5b5	198	21	(	(	-LRB-
cord-344093-3bniy5b5	198	22	DNAdependent	dnadependent	NN
cord-344093-3bniy5b5	198	23	activator	activator	NN
cord-344093-3bniy5b5	198	24	of	of	IN
cord-344093-3bniy5b5	198	25	IRFs	IRFs	NNP
cord-344093-3bniy5b5	198	26	)	)	-RRB-
cord-344093-3bniy5b5	198	27	initiates	initiate	VBZ
cord-344093-3bniy5b5	198	28	necroptosis	necroptosis	NN
cord-344093-3bniy5b5	198	29	via	via	IN
cord-344093-3bniy5b5	198	30	RIP1	RIP1	NNP
cord-344093-3bniy5b5	198	31	/	/	SYM
cord-344093-3bniy5b5	198	32	RIP3	RIP3	NNP
cord-344093-3bniy5b5	198	33	activation	activation	NN
cord-344093-3bniy5b5	198	34	,	,	,
cord-344093-3bniy5b5	198	35	respectively	respectively	RB
cord-344093-3bniy5b5	198	36	(	(	-LRB-
cord-344093-3bniy5b5	198	37	117	117	CD
cord-344093-3bniy5b5	198	38	,	,	,
cord-344093-3bniy5b5	198	39	121	121	CD
cord-344093-3bniy5b5	198	40	)	)	-RRB-
cord-344093-3bniy5b5	198	41	.	.	.
cord-344093-3bniy5b5	199	1	Importantly	importantly	RB
cord-344093-3bniy5b5	199	2	,	,	,
cord-344093-3bniy5b5	199	3	the	the	DT
cord-344093-3bniy5b5	199	4	activation	activation	NN
cord-344093-3bniy5b5	199	5	of	of	IN
cord-344093-3bniy5b5	199	6	proapoptotic	proapoptotic	JJ
cord-344093-3bniy5b5	199	7	and	and	CC
cord-344093-3bniy5b5	199	8	pro	pro	JJ
cord-344093-3bniy5b5	199	9	-	-	JJ
cord-344093-3bniy5b5	199	10	necroptotic	necroptotic	JJ
cord-344093-3bniy5b5	199	11	pathways	pathway	NNS
cord-344093-3bniy5b5	199	12	in	in	IN
cord-344093-3bniy5b5	199	13	respiratory	respiratory	JJ
cord-344093-3bniy5b5	199	14	infection	infection	NN
cord-344093-3bniy5b5	199	15	can	can	MD
cord-344093-3bniy5b5	199	16	result	result	VB
cord-344093-3bniy5b5	199	17	in	in	IN
cord-344093-3bniy5b5	199	18	a	a	DT
cord-344093-3bniy5b5	199	19	structural	structural	JJ
cord-344093-3bniy5b5	199	20	disruption	disruption	NN
cord-344093-3bniy5b5	199	21	of	of	IN
cord-344093-3bniy5b5	199	22	the	the	DT
cord-344093-3bniy5b5	199	23	airway	airway	NN
cord-344093-3bniy5b5	199	24	and	and	CC
cord-344093-3bniy5b5	199	25	the	the	DT
cord-344093-3bniy5b5	199	26	alveolar	alveolar	JJ
cord-344093-3bniy5b5	199	27	epithelial	epithelial	JJ
cord-344093-3bniy5b5	199	28	barrier	barrier	NN
cord-344093-3bniy5b5	199	29	,	,	,
cord-344093-3bniy5b5	199	30	which	which	WDT
cord-344093-3bniy5b5	199	31	is	be	VBZ
cord-344093-3bniy5b5	199	32	a	a	DT
cord-344093-3bniy5b5	199	33	major	major	JJ
cord-344093-3bniy5b5	199	34	hallmark	hallmark	NN
cord-344093-3bniy5b5	199	35	of	of	IN
cord-344093-3bniy5b5	199	36	respiratory	respiratory	JJ
cord-344093-3bniy5b5	199	37	disease	disease	NN
cord-344093-3bniy5b5	199	38	and	and	CC
cord-344093-3bniy5b5	199	39	its	-PRON-	PRP$
cord-344093-3bniy5b5	199	40	progression	progression	NN
cord-344093-3bniy5b5	199	41	to	to	IN
cord-344093-3bniy5b5	199	42	the	the	DT
cord-344093-3bniy5b5	199	43	acute	acute	JJ
cord-344093-3bniy5b5	199	44	respiratory	respiratory	JJ
cord-344093-3bniy5b5	199	45	distress	distress	NN
cord-344093-3bniy5b5	199	46	syndrome	syndrome	NN
cord-344093-3bniy5b5	199	47	(	(	-LRB-
cord-344093-3bniy5b5	199	48	122	122	CD
cord-344093-3bniy5b5	199	49	,	,	,
cord-344093-3bniy5b5	199	50	123	123	CD
cord-344093-3bniy5b5	199	51	)	)	-RRB-
cord-344093-3bniy5b5	199	52	.	.	.
cord-344093-3bniy5b5	200	1	In	in	IN
cord-344093-3bniy5b5	200	2	virusinduced	virusinduced	JJ
cord-344093-3bniy5b5	200	3	lung	lung	NN
cord-344093-3bniy5b5	200	4	injury	injury	NN
cord-344093-3bniy5b5	200	5	,	,	,
cord-344093-3bniy5b5	200	6	especially	especially	RB
cord-344093-3bniy5b5	200	7	expression	expression	NN
cord-344093-3bniy5b5	200	8	of	of	IN
cord-344093-3bniy5b5	200	9	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	200	10	,	,	,
cord-344093-3bniy5b5	200	11	which	which	WDT
cord-344093-3bniy5b5	200	12	can	can	MD
cord-344093-3bniy5b5	200	13	initiate	initiate	VB
cord-344093-3bniy5b5	200	14	both	both	DT
cord-344093-3bniy5b5	200	15	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	200	16	as	as	RB
cord-344093-3bniy5b5	200	17	well	well	RB
cord-344093-3bniy5b5	200	18	as	as	IN
cord-344093-3bniy5b5	200	19	necroptosis	necroptosis	NNP
cord-344093-3bniy5b5	200	20	has	have	VBZ
cord-344093-3bniy5b5	200	21	been	be	VBN
cord-344093-3bniy5b5	200	22	correlated	correlate	VBN
cord-344093-3bniy5b5	200	23	with	with	IN
cord-344093-3bniy5b5	200	24	more	more	JJR
cord-344093-3bniy5b5	200	25	severe	severe	JJ
cord-344093-3bniy5b5	200	26	outcomes	outcome	NNS
cord-344093-3bniy5b5	200	27	.	.	.
cord-344093-3bniy5b5	201	1	As	as	IN
cord-344093-3bniy5b5	201	2	described	describe	VBN
cord-344093-3bniy5b5	201	3	earlier	early	RBR
cord-344093-3bniy5b5	201	4	,	,	,
cord-344093-3bniy5b5	201	5	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	201	6	belongs	belong	VBZ
cord-344093-3bniy5b5	201	7	to	to	IN
cord-344093-3bniy5b5	201	8	the	the	DT
cord-344093-3bniy5b5	201	9	superfamily	superfamily	NN
cord-344093-3bniy5b5	201	10	of	of	IN
cord-344093-3bniy5b5	201	11	TNF	TNF	NNP
cord-344093-3bniy5b5	201	12	ligands	ligand	NNS
cord-344093-3bniy5b5	201	13	and	and	CC
cord-344093-3bniy5b5	201	14	has	have	VBZ
cord-344093-3bniy5b5	201	15	been	be	VBN
cord-344093-3bniy5b5	201	16	reported	report	VBN
cord-344093-3bniy5b5	201	17	to	to	TO
cord-344093-3bniy5b5	201	18	be	be	VB
cord-344093-3bniy5b5	201	19	inducible	inducible	JJ
cord-344093-3bniy5b5	201	20	by	by	IN
cord-344093-3bniy5b5	201	21	both	both	DT
cord-344093-3bniy5b5	201	22	type	type	NN
cord-344093-3bniy5b5	201	23	I	-PRON-	PRP
cord-344093-3bniy5b5	201	24	and	and	CC
cord-344093-3bniy5b5	201	25	type	type	NN
cord-344093-3bniy5b5	201	26	III	iii	CD
cord-344093-3bniy5b5	201	27	IFNs	ifn	NNS
cord-344093-3bniy5b5	201	28	.	.	.
cord-344093-3bniy5b5	202	1	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	202	2	has	have	VBZ
cord-344093-3bniy5b5	202	3	been	be	VBN
cord-344093-3bniy5b5	202	4	found	find	VBN
cord-344093-3bniy5b5	202	5	to	to	TO
cord-344093-3bniy5b5	202	6	be	be	VB
cord-344093-3bniy5b5	202	7	present	present	JJ
cord-344093-3bniy5b5	202	8	in	in	IN
cord-344093-3bniy5b5	202	9	various	various	JJ
cord-344093-3bniy5b5	202	10	cells	cell	NNS
cord-344093-3bniy5b5	202	11	of	of	IN
cord-344093-3bniy5b5	202	12	the	the	DT
cord-344093-3bniy5b5	202	13	immune	immune	JJ
cord-344093-3bniy5b5	202	14	system	system	NN
cord-344093-3bniy5b5	202	15	,	,	,
cord-344093-3bniy5b5	202	16	among	among	IN
cord-344093-3bniy5b5	202	17	them	-PRON-	PRP
cord-344093-3bniy5b5	202	18	natural	natural	JJ
cord-344093-3bniy5b5	202	19	killer	killer	NN
cord-344093-3bniy5b5	202	20	(	(	-LRB-
cord-344093-3bniy5b5	202	21	NK	NK	NNP
cord-344093-3bniy5b5	202	22	)	)	-RRB-
cord-344093-3bniy5b5	202	23	cells	cell	NNS
cord-344093-3bniy5b5	202	24	,	,	,
cord-344093-3bniy5b5	202	25	T	t	NN
cord-344093-3bniy5b5	202	26	cells	cell	NNS
cord-344093-3bniy5b5	202	27	,	,	,
cord-344093-3bniy5b5	202	28	NK	NK	NNP
cord-344093-3bniy5b5	202	29	T	T	NNP
cord-344093-3bniy5b5	202	30	cells	cell	NNS
cord-344093-3bniy5b5	202	31	,	,	,
cord-344093-3bniy5b5	202	32	DC	DC	NNP
cord-344093-3bniy5b5	202	33	subsets	subset	NNS
cord-344093-3bniy5b5	202	34	such	such	JJ
cord-344093-3bniy5b5	202	35	as	as	IN
cord-344093-3bniy5b5	202	36	IFN	IFN	NNP
cord-344093-3bniy5b5	202	37	-	-	HYPH
cord-344093-3bniy5b5	202	38	γ	γ	NNP
cord-344093-3bniy5b5	202	39	-	-	HYPH
cord-344093-3bniy5b5	202	40	producing	produce	VBG
cord-344093-3bniy5b5	202	41	killer	killer	NN
cord-344093-3bniy5b5	202	42	DCs	dc	NNS
cord-344093-3bniy5b5	202	43	and	and	CC
cord-344093-3bniy5b5	202	44	macrophages	macrophage	NNS
cord-344093-3bniy5b5	202	45	,	,	,
cord-344093-3bniy5b5	202	46	and	and	CC
cord-344093-3bniy5b5	202	47	can	can	MD
cord-344093-3bniy5b5	202	48	be	be	VB
cord-344093-3bniy5b5	202	49	displayed	display	VBN
cord-344093-3bniy5b5	202	50	in	in	IN
cord-344093-3bniy5b5	202	51	large	large	JJ
cord-344093-3bniy5b5	202	52	amounts	amount	NNS
cord-344093-3bniy5b5	202	53	on	on	IN
cord-344093-3bniy5b5	202	54	the	the	DT
cord-344093-3bniy5b5	202	55	cell	cell	NN
cord-344093-3bniy5b5	202	56	surface	surface	NN
cord-344093-3bniy5b5	202	57	or	or	CC
cord-344093-3bniy5b5	202	58	be	be	VB
cord-344093-3bniy5b5	202	59	shed	shed	VBN
cord-344093-3bniy5b5	202	60	upon	upon	IN
cord-344093-3bniy5b5	202	61	IFN	IFN	NNP
cord-344093-3bniy5b5	202	62	-	-	HYPH
cord-344093-3bniy5b5	202	63	and	and	CC
cord-344093-3bniy5b5	202	64	/	/	SYM
cord-344093-3bniy5b5	202	65	or	or	CC
cord-344093-3bniy5b5	202	66	pro	pro	JJ
cord-344093-3bniy5b5	202	67	-	-	JJ
cord-344093-3bniy5b5	202	68	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	202	69	cytokine	cytokine	NN
cord-344093-3bniy5b5	202	70	signaling	signaling	NN
cord-344093-3bniy5b5	202	71	(	(	-LRB-
cord-344093-3bniy5b5	202	72	124	124	CD
cord-344093-3bniy5b5	202	73	)	)	-RRB-
cord-344093-3bniy5b5	203	1	(	(	-LRB-
cord-344093-3bniy5b5	203	2	125	125	CD
cord-344093-3bniy5b5	203	3	)	)	-RRB-
cord-344093-3bniy5b5	203	4	(	(	-LRB-
cord-344093-3bniy5b5	203	5	126	126	CD
cord-344093-3bniy5b5	203	6	)	)	-RRB-
cord-344093-3bniy5b5	203	7	.	.	.
cord-344093-3bniy5b5	204	1	In	in	IN
cord-344093-3bniy5b5	204	2	addition	addition	NN
cord-344093-3bniy5b5	204	3	to	to	IN
cord-344093-3bniy5b5	204	4	cells	cell	NNS
cord-344093-3bniy5b5	204	5	of	of	IN
cord-344093-3bniy5b5	204	6	the	the	DT
cord-344093-3bniy5b5	204	7	immune	immune	JJ
cord-344093-3bniy5b5	204	8	system	system	NN
cord-344093-3bniy5b5	204	9	,	,	,
cord-344093-3bniy5b5	204	10	fibroblasts	fibroblast	NNS
cord-344093-3bniy5b5	204	11	have	have	VBP
cord-344093-3bniy5b5	204	12	been	be	VBN
cord-344093-3bniy5b5	204	13	shown	show	VBN
cord-344093-3bniy5b5	204	14	to	to	TO
cord-344093-3bniy5b5	204	15	produce	produce	VB
cord-344093-3bniy5b5	204	16	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	204	17	after	after	IN
cord-344093-3bniy5b5	204	18	IFNγ	IFNγ	NNS
cord-344093-3bniy5b5	204	19	treatment	treatment	NN
cord-344093-3bniy5b5	204	20	or	or	CC
cord-344093-3bniy5b5	204	21	viral	viral	JJ
cord-344093-3bniy5b5	204	22	challenge	challenge	NN
cord-344093-3bniy5b5	204	23	.	.	.
cord-344093-3bniy5b5	205	1	Also	also	RB
cord-344093-3bniy5b5	205	2	,	,	,
cord-344093-3bniy5b5	205	3	club	club	NN
cord-344093-3bniy5b5	205	4	cells	cell	NNS
cord-344093-3bniy5b5	205	5	and	and	CC
cord-344093-3bniy5b5	205	6	the	the	DT
cord-344093-3bniy5b5	205	7	alveolar	alveolar	JJ
cord-344093-3bniy5b5	205	8	epithelium	epithelium	NN
cord-344093-3bniy5b5	205	9	have	have	VBP
cord-344093-3bniy5b5	205	10	been	be	VBN
cord-344093-3bniy5b5	205	11	reported	report	VBN
cord-344093-3bniy5b5	205	12	to	to	TO
cord-344093-3bniy5b5	205	13	produce	produce	VB
cord-344093-3bniy5b5	205	14	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	205	15	(	(	-LRB-
cord-344093-3bniy5b5	205	16	127	127	CD
cord-344093-3bniy5b5	205	17	)	)	-RRB-
cord-344093-3bniy5b5	205	18	(	(	-LRB-
cord-344093-3bniy5b5	205	19	128	128	CD
cord-344093-3bniy5b5	205	20	)	)	-RRB-
cord-344093-3bniy5b5	205	21	(	(	-LRB-
cord-344093-3bniy5b5	205	22	129	129	CD
cord-344093-3bniy5b5	205	23	)	)	-RRB-
cord-344093-3bniy5b5	205	24	(	(	-LRB-
cord-344093-3bniy5b5	205	25	130	130	CD
cord-344093-3bniy5b5	205	26	)	)	-RRB-
cord-344093-3bniy5b5	205	27	.	.	.
cord-344093-3bniy5b5	206	1	Similar	similar	JJ
cord-344093-3bniy5b5	206	2	to	to	IN
cord-344093-3bniy5b5	206	3	other	other	JJ
cord-344093-3bniy5b5	206	4	ligands	ligand	NNS
cord-344093-3bniy5b5	206	5	of	of	IN
cord-344093-3bniy5b5	206	6	the	the	DT
cord-344093-3bniy5b5	206	7	TNF	TNF	NNP
cord-344093-3bniy5b5	206	8	superfamily	superfamily	NN
cord-344093-3bniy5b5	206	9	,	,	,
cord-344093-3bniy5b5	206	10	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	206	11	is	be	VBZ
cord-344093-3bniy5b5	206	12	a	a	DT
cord-344093-3bniy5b5	206	13	homotrimeric	homotrimeric	JJ
cord-344093-3bniy5b5	206	14	type	type	NN
cord-344093-3bniy5b5	206	15	II	II	NNP
cord-344093-3bniy5b5	206	16	transmembrane	transmembrane	NN
cord-344093-3bniy5b5	206	17	protein	protein	NN
cord-344093-3bniy5b5	206	18	with	with	IN
cord-344093-3bniy5b5	206	19	a	a	DT
cord-344093-3bniy5b5	206	20	conserved	conserved	JJ
cord-344093-3bniy5b5	206	21	C	c	NN
cord-344093-3bniy5b5	206	22	-	-	HYPH
cord-344093-3bniy5b5	206	23	terminal	terminal	NN
cord-344093-3bniy5b5	206	24	extracellular	extracellular	JJ
cord-344093-3bniy5b5	206	25	domain	domain	NN
cord-344093-3bniy5b5	206	26	that	that	WDT
cord-344093-3bniy5b5	206	27	mediates	mediate	VBZ
cord-344093-3bniy5b5	206	28	receptor	receptor	NN
cord-344093-3bniy5b5	206	29	binding	binding	NN
cord-344093-3bniy5b5	206	30	and	and	CC
cord-344093-3bniy5b5	206	31	can	can	MD
cord-344093-3bniy5b5	206	32	be	be	VB
cord-344093-3bniy5b5	206	33	cleaved	cleave	VBN
cord-344093-3bniy5b5	206	34	by	by	IN
cord-344093-3bniy5b5	206	35	metalloproteinases	metalloproteinase	NNS
cord-344093-3bniy5b5	206	36	to	to	TO
cord-344093-3bniy5b5	206	37	generate	generate	VB
cord-344093-3bniy5b5	206	38	a	a	DT
cord-344093-3bniy5b5	206	39	soluble	soluble	JJ
cord-344093-3bniy5b5	206	40	mediator	mediator	NN
cord-344093-3bniy5b5	206	41	(	(	-LRB-
cord-344093-3bniy5b5	206	42	131	131	CD
cord-344093-3bniy5b5	206	43	)	)	-RRB-
cord-344093-3bniy5b5	206	44	.	.	.
cord-344093-3bniy5b5	207	1	However	however	RB
cord-344093-3bniy5b5	207	2	,	,	,
cord-344093-3bniy5b5	207	3	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	207	4	can	can	MD
cord-344093-3bniy5b5	207	5	induce	induce	VB
cord-344093-3bniy5b5	207	6	cell	cell	NN
cord-344093-3bniy5b5	207	7	death	death	NN
cord-344093-3bniy5b5	207	8	also	also	RB
cord-344093-3bniy5b5	207	9	in	in	IN
cord-344093-3bniy5b5	207	10	its	-PRON-	PRP$
cord-344093-3bniy5b5	207	11	membrane	membrane	NN
cord-344093-3bniy5b5	207	12	-	-	HYPH
cord-344093-3bniy5b5	207	13	bound	bind	VBN
cord-344093-3bniy5b5	207	14	form	form	NN
cord-344093-3bniy5b5	207	15	,	,	,
cord-344093-3bniy5b5	207	16	that	that	RB
cord-344093-3bniy5b5	207	17	is	is	RB
cord-344093-3bniy5b5	207	18	,	,	,
cord-344093-3bniy5b5	207	19	similar	similar	JJ
cord-344093-3bniy5b5	207	20	to	to	IN
cord-344093-3bniy5b5	207	21	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	207	22	expression	expression	NN
cord-344093-3bniy5b5	207	23	levels	level	NNS
cord-344093-3bniy5b5	207	24	and	and	CC
cord-344093-3bniy5b5	207	25	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	207	26	shedding	shed	VBG
cord-344093-3bniy5b5	207	27	,	,	,
cord-344093-3bniy5b5	207	28	upregulated	upregulate	VBN
cord-344093-3bniy5b5	207	29	by	by	IN
cord-344093-3bniy5b5	207	30	type	type	NN
cord-344093-3bniy5b5	207	31	I	-PRON-	PRP
cord-344093-3bniy5b5	207	32	IFN	IFN	NNP
cord-344093-3bniy5b5	207	33	(	(	-LRB-
cord-344093-3bniy5b5	207	34	126	126	CD
cord-344093-3bniy5b5	207	35	)	)	-RRB-
cord-344093-3bniy5b5	207	36	.	.	.
cord-344093-3bniy5b5	208	1	Direct	direct	JJ
cord-344093-3bniy5b5	208	2	cell	cell	NN
cord-344093-3bniy5b5	208	3	-	-	HYPH
cord-344093-3bniy5b5	208	4	to	to	IN
cord-344093-3bniy5b5	208	5	-	-	HYPH
cord-344093-3bniy5b5	208	6	cell	cell	NN
cord-344093-3bniy5b5	208	7	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	208	8	-	-	HYPH
cord-344093-3bniy5b5	208	9	DR	DR	NNP
cord-344093-3bniy5b5	208	10	interactions	interaction	NNS
cord-344093-3bniy5b5	208	11	have	have	VBP
cord-344093-3bniy5b5	208	12	been	be	VBN
cord-344093-3bniy5b5	208	13	demonstrated	demonstrate	VBN
cord-344093-3bniy5b5	208	14	to	to	TO
cord-344093-3bniy5b5	208	15	play	play	VB
cord-344093-3bniy5b5	208	16	a	a	DT
cord-344093-3bniy5b5	208	17	role	role	NN
cord-344093-3bniy5b5	208	18	in	in	IN
cord-344093-3bniy5b5	208	19	macrophage	macrophage	NN
cord-344093-3bniy5b5	208	20	,	,	,
cord-344093-3bniy5b5	208	21	NK	NK	NNP
cord-344093-3bniy5b5	208	22	as	as	RB
cord-344093-3bniy5b5	208	23	well	well	RB
cord-344093-3bniy5b5	208	24	as	as	IN
cord-344093-3bniy5b5	208	25	CD4	CD4	NNP
cord-344093-3bniy5b5	208	26	+	+	CC
cord-344093-3bniy5b5	208	27	T	T	NNP
cord-344093-3bniy5b5	208	28	cell	cell	NN
cord-344093-3bniy5b5	208	29	-	-	HYPH
cord-344093-3bniy5b5	208	30	mediated	mediate	VBN
cord-344093-3bniy5b5	208	31	induction	induction	NN
cord-344093-3bniy5b5	208	32	of	of	IN
cord-344093-3bniy5b5	208	33	cellular	cellular	JJ
cord-344093-3bniy5b5	208	34	death	death	NN
cord-344093-3bniy5b5	208	35	(	(	-LRB-
cord-344093-3bniy5b5	208	36	132	132	CD
cord-344093-3bniy5b5	208	37	,	,	,
cord-344093-3bniy5b5	208	38	133	133	CD
cord-344093-3bniy5b5	208	39	)	)	-RRB-
cord-344093-3bniy5b5	208	40	.	.	.
cord-344093-3bniy5b5	209	1	In	in	IN
cord-344093-3bniy5b5	209	2	humans	human	NNS
cord-344093-3bniy5b5	209	3	,	,	,
cord-344093-3bniy5b5	209	4	five	five	CD
cord-344093-3bniy5b5	209	5	different	different	JJ
cord-344093-3bniy5b5	209	6	binding	bind	VBG
cord-344093-3bniy5b5	209	7	partners	partner	NNS
cord-344093-3bniy5b5	209	8	for	for	IN
cord-344093-3bniy5b5	209	9	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	209	10	are	be	VBP
cord-344093-3bniy5b5	209	11	present	present	JJ
cord-344093-3bniy5b5	209	12	:	:	:
cord-344093-3bniy5b5	210	1	the	the	DT
cord-344093-3bniy5b5	210	2	membrane	membrane	NN
cord-344093-3bniy5b5	210	3	-	-	HYPH
cord-344093-3bniy5b5	210	4	bound	bind	VBN
cord-344093-3bniy5b5	210	5	DR4	dr4	NN
cord-344093-3bniy5b5	210	6	(	(	-LRB-
cord-344093-3bniy5b5	210	7	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	210	8	-	-	HYPH
cord-344093-3bniy5b5	210	9	R1	R1	NNP
cord-344093-3bniy5b5	210	10	)	)	-RRB-
cord-344093-3bniy5b5	210	11	and	and	CC
cord-344093-3bniy5b5	210	12	DR5	DR5	NNP
cord-344093-3bniy5b5	210	13	(	(	-LRB-
cord-344093-3bniy5b5	210	14	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	210	15	-	-	HYPH
cord-344093-3bniy5b5	210	16	R2	R2	NNP
cord-344093-3bniy5b5	210	17	)	)	-RRB-
cord-344093-3bniy5b5	210	18	that	that	IN
cord-344093-3bniy5b5	210	19	both	both	DT
cord-344093-3bniy5b5	210	20	induce	induce	VBP
cord-344093-3bniy5b5	210	21	a	a	DT
cord-344093-3bniy5b5	210	22	proapoptotic	proapoptotic	JJ
cord-344093-3bniy5b5	210	23	signaling	signaling	NN
cord-344093-3bniy5b5	210	24	cascade	cascade	NN
cord-344093-3bniy5b5	210	25	,	,	,
cord-344093-3bniy5b5	210	26	the	the	DT
cord-344093-3bniy5b5	210	27	membrane	membrane	NN
cord-344093-3bniy5b5	210	28	-	-	HYPH
cord-344093-3bniy5b5	210	29	bound	bind	VBN
cord-344093-3bniy5b5	210	30	anti	anti	JJ
cord-344093-3bniy5b5	210	31	-	-	JJ
cord-344093-3bniy5b5	210	32	apoptotic	apoptotic	JJ
cord-344093-3bniy5b5	210	33	decoy	decoy	NN
cord-344093-3bniy5b5	210	34	receptors	receptor	NNS
cord-344093-3bniy5b5	210	35	(	(	-LRB-
cord-344093-3bniy5b5	210	36	DcR)1	DcR)1	NNP
cord-344093-3bniy5b5	210	37	and	and	CC
cord-344093-3bniy5b5	210	38	DcR2	DcR2	NNS
cord-344093-3bniy5b5	210	39	,	,	,
cord-344093-3bniy5b5	210	40	and	and	CC
cord-344093-3bniy5b5	210	41	the	the	DT
cord-344093-3bniy5b5	210	42	soluble	soluble	JJ
cord-344093-3bniy5b5	210	43	interaction	interaction	NN
cord-344093-3bniy5b5	210	44	partner	partner	NN
cord-344093-3bniy5b5	210	45	osteoprotegerin	osteoprotegerin	NNP
cord-344093-3bniy5b5	210	46	(	(	-LRB-
cord-344093-3bniy5b5	210	47	134	134	CD
cord-344093-3bniy5b5	210	48	)	)	-RRB-
cord-344093-3bniy5b5	210	49	.	.	.
cord-344093-3bniy5b5	211	1	In	in	IN
cord-344093-3bniy5b5	211	2	the	the	DT
cord-344093-3bniy5b5	211	3	murine	murine	JJ
cord-344093-3bniy5b5	211	4	system	system	NN
cord-344093-3bniy5b5	211	5	,	,	,
cord-344093-3bniy5b5	211	6	only	only	RB
cord-344093-3bniy5b5	211	7	DR5	DR5	NNP
cord-344093-3bniy5b5	211	8	has	have	VBZ
cord-344093-3bniy5b5	211	9	been	be	VBN
cord-344093-3bniy5b5	211	10	identified	identify	VBN
cord-344093-3bniy5b5	211	11	to	to	TO
cord-344093-3bniy5b5	211	12	ligate	ligate	VB
cord-344093-3bniy5b5	211	13	to	to	IN
cord-344093-3bniy5b5	211	14	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	211	15	(	(	-LRB-
cord-344093-3bniy5b5	211	16	135	135	CD
cord-344093-3bniy5b5	211	17	)	)	-RRB-
cord-344093-3bniy5b5	211	18	.	.	.
cord-344093-3bniy5b5	212	1	In	in	IN
cord-344093-3bniy5b5	212	2	the	the	DT
cord-344093-3bniy5b5	212	3	human	human	JJ
cord-344093-3bniy5b5	212	4	respiratory	respiratory	JJ
cord-344093-3bniy5b5	212	5	compartment	compartment	NN
cord-344093-3bniy5b5	212	6	,	,	,
cord-344093-3bniy5b5	212	7	both	both	CC
cord-344093-3bniy5b5	212	8	DR4	dr4	NN
cord-344093-3bniy5b5	212	9	and	and	CC
cord-344093-3bniy5b5	212	10	DR5	DR5	NNP
cord-344093-3bniy5b5	212	11	have	have	VBP
cord-344093-3bniy5b5	212	12	been	be	VBN
cord-344093-3bniy5b5	212	13	demonstrated	demonstrate	VBN
cord-344093-3bniy5b5	212	14	to	to	TO
cord-344093-3bniy5b5	212	15	be	be	VB
cord-344093-3bniy5b5	212	16	present	present	JJ
cord-344093-3bniy5b5	212	17	under	under	IN
cord-344093-3bniy5b5	212	18	steady	steady	JJ
cord-344093-3bniy5b5	212	19	-	-	HYPH
cord-344093-3bniy5b5	212	20	state	state	NN
cord-344093-3bniy5b5	212	21	conditions	condition	NNS
cord-344093-3bniy5b5	212	22	(	(	-LRB-
cord-344093-3bniy5b5	212	23	136	136	CD
cord-344093-3bniy5b5	212	24	,	,	,
cord-344093-3bniy5b5	212	25	137	137	CD
cord-344093-3bniy5b5	212	26	)	)	-RRB-
cord-344093-3bniy5b5	212	27	.	.	.
cord-344093-3bniy5b5	213	1	However	however	RB
cord-344093-3bniy5b5	213	2	,	,	,
cord-344093-3bniy5b5	213	3	upon	upon	IN
cord-344093-3bniy5b5	213	4	viral	viral	JJ
cord-344093-3bniy5b5	213	5	infection	infection	NN
cord-344093-3bniy5b5	213	6	,	,	,
cord-344093-3bniy5b5	213	7	cell	cell	NN
cord-344093-3bniy5b5	213	8	-	-	HYPH
cord-344093-3bniy5b5	213	9	sensitivity	sensitivity	NN
cord-344093-3bniy5b5	213	10	to	to	IN
cord-344093-3bniy5b5	213	11	TRAIL	trail	NN
cord-344093-3bniy5b5	213	12	-	-	HYPH
cord-344093-3bniy5b5	213	13	induced	induce	VBN
cord-344093-3bniy5b5	213	14	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	213	15	is	be	VBZ
cord-344093-3bniy5b5	213	16	enhanced	enhance	VBN
cord-344093-3bniy5b5	213	17	,	,	,
cord-344093-3bniy5b5	213	18	which	which	WDT
cord-344093-3bniy5b5	213	19	has	have	VBZ
cord-344093-3bniy5b5	213	20	been	be	VBN
cord-344093-3bniy5b5	213	21	attributed	attribute	VBN
cord-344093-3bniy5b5	213	22	to	to	IN
cord-344093-3bniy5b5	213	23	increased	increase	VBN
cord-344093-3bniy5b5	213	24	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	213	25	receptor	receptor	NN
cord-344093-3bniy5b5	213	26	expression	expression	NN
cord-344093-3bniy5b5	213	27	especially	especially	RB
cord-344093-3bniy5b5	213	28	on	on	IN
cord-344093-3bniy5b5	213	29	infected	infected	JJ
cord-344093-3bniy5b5	213	30	cells	cell	NNS
cord-344093-3bniy5b5	213	31	,	,	,
cord-344093-3bniy5b5	213	32	as	as	IN
cord-344093-3bniy5b5	213	33	DR	DR	NNP
cord-344093-3bniy5b5	213	34	levels	level	NNS
cord-344093-3bniy5b5	213	35	are	be	VBP
cord-344093-3bniy5b5	213	36	markedly	markedly	RB
cord-344093-3bniy5b5	213	37	increased	increase	VBN
cord-344093-3bniy5b5	213	38	in	in	IN
cord-344093-3bniy5b5	213	39	IAV-	IAV-	NNP
cord-344093-3bniy5b5	213	40	,	,	,
cord-344093-3bniy5b5	213	41	adenovirus-	adenovirus-	RB
cord-344093-3bniy5b5	213	42	,	,	,
cord-344093-3bniy5b5	213	43	and	and	CC
cord-344093-3bniy5b5	213	44	paramyxovirus	paramyxovirus	NN
cord-344093-3bniy5b5	213	45	-	-	HYPH
cord-344093-3bniy5b5	213	46	infected	infect	VBN
cord-344093-3bniy5b5	213	47	cells	cell	NNS
cord-344093-3bniy5b5	213	48	in	in	IN
cord-344093-3bniy5b5	213	49	contrast	contrast	NN
cord-344093-3bniy5b5	213	50	to	to	IN
cord-344093-3bniy5b5	213	51	non	non	JJ
cord-344093-3bniy5b5	213	52	-	-	JJ
cord-344093-3bniy5b5	213	53	infected	infected	JJ
cord-344093-3bniy5b5	213	54	bystander	bystander	NN
cord-344093-3bniy5b5	213	55	cells	cell	NNS
cord-344093-3bniy5b5	213	56	(	(	-LRB-
cord-344093-3bniy5b5	213	57	10	10	CD
cord-344093-3bniy5b5	213	58	,	,	,
cord-344093-3bniy5b5	213	59	138	138	CD
cord-344093-3bniy5b5	213	60	,	,	,
cord-344093-3bniy5b5	213	61	139	139	CD
cord-344093-3bniy5b5	213	62	)	)	-RRB-
cord-344093-3bniy5b5	213	63	.	.	.
cord-344093-3bniy5b5	214	1	Of	of	IN
cord-344093-3bniy5b5	214	2	note	note	NN
cord-344093-3bniy5b5	214	3	,	,	,
cord-344093-3bniy5b5	214	4	studies	study	NNS
cord-344093-3bniy5b5	214	5	on	on	IN
cord-344093-3bniy5b5	214	6	the	the	DT
cord-344093-3bniy5b5	214	7	dependency	dependency	NN
cord-344093-3bniy5b5	214	8	of	of	IN
cord-344093-3bniy5b5	214	9	DR	DR	NNP
cord-344093-3bniy5b5	214	10	upregulation	upregulation	NN
cord-344093-3bniy5b5	214	11	upon	upon	IN
cord-344093-3bniy5b5	214	12	type	type	NN
cord-344093-3bniy5b5	215	1	I	-PRON-	PRP
cord-344093-3bniy5b5	215	2	IFN	IFN	NNP
cord-344093-3bniy5b5	215	3	signaling	signal	VBG
cord-344093-3bniy5b5	215	4	after	after	IN
cord-344093-3bniy5b5	215	5	IAV	IAV	NNP
cord-344093-3bniy5b5	215	6	infection	infection	NN
cord-344093-3bniy5b5	215	7	have	have	VBP
cord-344093-3bniy5b5	215	8	yielded	yield	VBN
cord-344093-3bniy5b5	215	9	conflicting	conflicting	JJ
cord-344093-3bniy5b5	215	10	results	result	NNS
cord-344093-3bniy5b5	215	11	in	in	IN
cord-344093-3bniy5b5	215	12	different	different	JJ
cord-344093-3bniy5b5	215	13	strains	strain	NNS
cord-344093-3bniy5b5	215	14	of	of	IN
cord-344093-3bniy5b5	215	15	mice	mouse	NNS
cord-344093-3bniy5b5	215	16	(	(	-LRB-
cord-344093-3bniy5b5	215	17	10	10	CD
cord-344093-3bniy5b5	215	18	,	,	,
cord-344093-3bniy5b5	215	19	74	74	CD
cord-344093-3bniy5b5	215	20	)	)	-RRB-
cord-344093-3bniy5b5	215	21	,	,	,
cord-344093-3bniy5b5	215	22	highlighting	highlight	VBG
cord-344093-3bniy5b5	215	23	the	the	DT
cord-344093-3bniy5b5	215	24	complex	complex	JJ
cord-344093-3bniy5b5	215	25	interplay	interplay	NN
cord-344093-3bniy5b5	215	26	of	of	IN
cord-344093-3bniy5b5	215	27	IFN	IFN	NNP
cord-344093-3bniy5b5	215	28	-	-	HYPH
cord-344093-3bniy5b5	215	29	induced	induce	VBN
cord-344093-3bniy5b5	215	30	cascades	cascade	VBZ
cord-344093-3bniy5b5	215	31	in	in	IN
cord-344093-3bniy5b5	215	32	a	a	DT
cord-344093-3bniy5b5	215	33	host	host	NN
cord-344093-3bniy5b5	215	34	-	-	:
cord-344093-3bniy5b5	215	35	and	and	CC
cord-344093-3bniy5b5	215	36	tissue	tissue	NN
cord-344093-3bniy5b5	215	37	-	-	HYPH
cord-344093-3bniy5b5	215	38	specific	specific	JJ
cord-344093-3bniy5b5	215	39	context	context	NN
cord-344093-3bniy5b5	215	40	,	,	,
cord-344093-3bniy5b5	215	41	whereas	whereas	IN
cord-344093-3bniy5b5	215	42	the	the	DT
cord-344093-3bniy5b5	215	43	exact	exact	JJ
cord-344093-3bniy5b5	215	44	virus	virus	NN
cord-344093-3bniy5b5	215	45	-	-	:
cord-344093-3bniy5b5	215	46	and	and	CC
cord-344093-3bniy5b5	215	47	host	host	NN
cord-344093-3bniy5b5	215	48	-	-	HYPH
cord-344093-3bniy5b5	215	49	specific	specific	JJ
cord-344093-3bniy5b5	215	50	mechanisms	mechanism	NNS
cord-344093-3bniy5b5	215	51	for	for	IN
cord-344093-3bniy5b5	215	52	DR	DR	NNP
cord-344093-3bniy5b5	215	53	regulation	regulation	NN
cord-344093-3bniy5b5	215	54	remain	remain	VBP
cord-344093-3bniy5b5	215	55	less	less	RBR
cord-344093-3bniy5b5	215	56	well	well	RB
cord-344093-3bniy5b5	215	57	defined	define	VBN
cord-344093-3bniy5b5	215	58	.	.	.
cord-344093-3bniy5b5	216	1	Moreover	moreover	RB
cord-344093-3bniy5b5	216	2	,	,	,
cord-344093-3bniy5b5	216	3	previous	previous	JJ
cord-344093-3bniy5b5	216	4	assumptions	assumption	NNS
cord-344093-3bniy5b5	216	5	that	that	WDT
cord-344093-3bniy5b5	216	6	also	also	RB
cord-344093-3bniy5b5	216	7	DcR	DcR	VBD
cord-344093-3bniy5b5	216	8	expression	expression	NN
cord-344093-3bniy5b5	216	9	would	would	MD
cord-344093-3bniy5b5	216	10	correlate	correlate	VB
cord-344093-3bniy5b5	216	11	with	with	IN
cord-344093-3bniy5b5	216	12	cell	cell	NN
cord-344093-3bniy5b5	216	13	-	-	HYPH
cord-344093-3bniy5b5	216	14	sensitivity	sensitivity	NN
cord-344093-3bniy5b5	216	15	to	to	IN
cord-344093-3bniy5b5	216	16	TRAIL	trail	NN
cord-344093-3bniy5b5	216	17	-	-	HYPH
cord-344093-3bniy5b5	216	18	induced	induce	VBN
cord-344093-3bniy5b5	216	19	cell	cell	NN
cord-344093-3bniy5b5	216	20	death	death	NN
cord-344093-3bniy5b5	216	21	could	could	MD
cord-344093-3bniy5b5	216	22	not	not	RB
cord-344093-3bniy5b5	216	23	be	be	VB
cord-344093-3bniy5b5	216	24	experimentally	experimentally	RB
cord-344093-3bniy5b5	216	25	verified	verify	VBN
cord-344093-3bniy5b5	216	26	(	(	-LRB-
cord-344093-3bniy5b5	216	27	125	125	CD
cord-344093-3bniy5b5	216	28	)	)	-RRB-
cord-344093-3bniy5b5	216	29	.	.	.
cord-344093-3bniy5b5	217	1	Tumor	tumor	NN
cord-344093-3bniy5b5	217	2	necrosis	necrosis	NN
cord-344093-3bniy5b5	217	3	factor	factor	NN
cord-344093-3bniy5b5	217	4	-	-	HYPH
cord-344093-3bniy5b5	217	5	related	relate	VBN
cord-344093-3bniy5b5	217	6	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	217	7	-	-	HYPH
cord-344093-3bniy5b5	217	8	inducing	induce	VBG
cord-344093-3bniy5b5	217	9	ligand	ligand	NN
cord-344093-3bniy5b5	217	10	ligation	ligation	NN
cord-344093-3bniy5b5	217	11	to	to	IN
cord-344093-3bniy5b5	217	12	the	the	DT
cord-344093-3bniy5b5	217	13	proapoptotic	proapoptotic	JJ
cord-344093-3bniy5b5	217	14	receptors	receptor	NNS
cord-344093-3bniy5b5	217	15	DR4	dr4	VBP
cord-344093-3bniy5b5	217	16	or	or	CC
cord-344093-3bniy5b5	217	17	DR5	DR5	NNP
cord-344093-3bniy5b5	217	18	triggers	trigger	VBZ
cord-344093-3bniy5b5	217	19	a	a	DT
cord-344093-3bniy5b5	217	20	trimerization	trimerization	NN
cord-344093-3bniy5b5	217	21	of	of	IN
cord-344093-3bniy5b5	217	22	the	the	DT
cord-344093-3bniy5b5	217	23	receptors	receptor	NNS
cord-344093-3bniy5b5	217	24	.	.	.
cord-344093-3bniy5b5	218	1	Subsequently	subsequently	RB
cord-344093-3bniy5b5	218	2	,	,	,
cord-344093-3bniy5b5	218	3	depending	depend	VBG
cord-344093-3bniy5b5	218	4	on	on	IN
cord-344093-3bniy5b5	218	5	additional	additional	JJ
cord-344093-3bniy5b5	218	6	stimuli	stimulus	NNS
cord-344093-3bniy5b5	218	7	,	,	,
cord-344093-3bniy5b5	218	8	presence	presence	NN
cord-344093-3bniy5b5	218	9	or	or	CC
cord-344093-3bniy5b5	218	10	absence	absence	NN
cord-344093-3bniy5b5	218	11	of	of	IN
cord-344093-3bniy5b5	218	12	adaptor	adaptor	NN
cord-344093-3bniy5b5	218	13	molecules	molecule	NNS
cord-344093-3bniy5b5	218	14	or	or	CC
cord-344093-3bniy5b5	218	15	inhibitory	inhibitory	JJ
cord-344093-3bniy5b5	218	16	proteins	protein	NNS
cord-344093-3bniy5b5	218	17	,	,	,
cord-344093-3bniy5b5	218	18	different	different	JJ
cord-344093-3bniy5b5	218	19	signaling	signal	VBG
cord-344093-3bniy5b5	218	20	pathways	pathway	NNS
cord-344093-3bniy5b5	218	21	can	can	MD
cord-344093-3bniy5b5	218	22	be	be	VB
cord-344093-3bniy5b5	218	23	activated	activate	VBN
cord-344093-3bniy5b5	219	1	(	(	-LRB-
cord-344093-3bniy5b5	219	2	Figure	figure	NN
cord-344093-3bniy5b5	219	3	2	2	CD
cord-344093-3bniy5b5	219	4	)	)	-RRB-
cord-344093-3bniy5b5	219	5	.	.	.
cord-344093-3bniy5b5	220	1	In	in	IN
cord-344093-3bniy5b5	220	2	the	the	DT
cord-344093-3bniy5b5	220	3	classical	classical	JJ
cord-344093-3bniy5b5	220	4	TRAIL	trail	NN
cord-344093-3bniy5b5	220	5	-	-	HYPH
cord-344093-3bniy5b5	220	6	dependent	dependent	JJ
cord-344093-3bniy5b5	220	7	extrinsic	extrinsic	JJ
cord-344093-3bniy5b5	220	8	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	220	9	induction	induction	NN
cord-344093-3bniy5b5	220	10	,	,	,
cord-344093-3bniy5b5	220	11	the	the	DT
cord-344093-3bniy5b5	220	12	proteins	protein	NNS
cord-344093-3bniy5b5	220	13	RIP	rip	VBP
cord-344093-3bniy5b5	220	14	,	,	,
cord-344093-3bniy5b5	220	15	TRADD	TRADD	NNP
cord-344093-3bniy5b5	220	16	,	,	,
cord-344093-3bniy5b5	220	17	and	and	CC
cord-344093-3bniy5b5	220	18	FADD	FADD	NNP
cord-344093-3bniy5b5	220	19	are	be	VBP
cord-344093-3bniy5b5	220	20	subsequently	subsequently	RB
cord-344093-3bniy5b5	220	21	recruited	recruit	VBN
cord-344093-3bniy5b5	220	22	to	to	IN
cord-344093-3bniy5b5	220	23	the	the	DT
cord-344093-3bniy5b5	220	24	DR	DR	NNP
cord-344093-3bniy5b5	220	25	cytoplasmic	cytoplasmic	JJ
cord-344093-3bniy5b5	220	26	domain	domain	NN
cord-344093-3bniy5b5	220	27	upon	upon	IN
cord-344093-3bniy5b5	220	28	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	220	29	ligation	ligation	NN
cord-344093-3bniy5b5	220	30	(	(	-LRB-
cord-344093-3bniy5b5	220	31	140	140	CD
cord-344093-3bniy5b5	220	32	,	,	,
cord-344093-3bniy5b5	220	33	141	141	CD
cord-344093-3bniy5b5	220	34	)	)	-RRB-
cord-344093-3bniy5b5	220	35	.	.	.
cord-344093-3bniy5b5	221	1	These	these	DT
cord-344093-3bniy5b5	221	2	factors	factor	NNS
cord-344093-3bniy5b5	221	3	and	and	CC
cord-344093-3bniy5b5	221	4	the	the	DT
cord-344093-3bniy5b5	221	5	proapoptotic	proapoptotic	JJ
cord-344093-3bniy5b5	221	6	DRs	DRs	NNPS
cord-344093-3bniy5b5	221	7	all	all	DT
cord-344093-3bniy5b5	221	8	share	share	VBP
cord-344093-3bniy5b5	221	9	a	a	DT
cord-344093-3bniy5b5	221	10	cytoplasmic	cytoplasmic	JJ
cord-344093-3bniy5b5	221	11	death	death	NN
cord-344093-3bniy5b5	221	12	domain	domain	NN
cord-344093-3bniy5b5	221	13	(	(	-LRB-
cord-344093-3bniy5b5	221	14	DD	DD	NNP
cord-344093-3bniy5b5	221	15	)	)	-RRB-
cord-344093-3bniy5b5	221	16	,	,	,
cord-344093-3bniy5b5	221	17	which	which	WDT
cord-344093-3bniy5b5	221	18	is	be	VBZ
cord-344093-3bniy5b5	221	19	lacking	lack	VBG
cord-344093-3bniy5b5	221	20	or	or	CC
cord-344093-3bniy5b5	221	21	truncated	truncated	JJ
cord-344093-3bniy5b5	221	22	and	and	CC
cord-344093-3bniy5b5	221	23	thus	thus	RB
cord-344093-3bniy5b5	221	24	inactive	inactive	JJ
cord-344093-3bniy5b5	221	25	in	in	IN
cord-344093-3bniy5b5	221	26	the	the	DT
cord-344093-3bniy5b5	221	27	DcR.	dcr.	NN
cord-344093-3bniy5b5	222	1	The	the	DT
cord-344093-3bniy5b5	222	2	DD	DD	NNP
cord-344093-3bniy5b5	222	3	plays	play	VBZ
cord-344093-3bniy5b5	222	4	a	a	DT
cord-344093-3bniy5b5	222	5	central	central	JJ
cord-344093-3bniy5b5	222	6	role	role	NN
cord-344093-3bniy5b5	222	7	in	in	IN
cord-344093-3bniy5b5	222	8	the	the	DT
cord-344093-3bniy5b5	222	9	concerted	concerted	JJ
cord-344093-3bniy5b5	222	10	formation	formation	NN
cord-344093-3bniy5b5	222	11	of	of	IN
cord-344093-3bniy5b5	222	12	the	the	DT
cord-344093-3bniy5b5	222	13	death	death	NN
cord-344093-3bniy5b5	222	14	-	-	HYPH
cord-344093-3bniy5b5	222	15	inducing	induce	VBG
cord-344093-3bniy5b5	222	16	signaling	signal	VBG
cord-344093-3bniy5b5	222	17	complex	complex	NN
cord-344093-3bniy5b5	222	18	(	(	-LRB-
cord-344093-3bniy5b5	222	19	DISC	disc	NN
cord-344093-3bniy5b5	222	20	)	)	-RRB-
cord-344093-3bniy5b5	222	21	.	.	.
cord-344093-3bniy5b5	223	1	DISC	disc	NN
cord-344093-3bniy5b5	223	2	formation	formation	NN
cord-344093-3bniy5b5	223	3	exposes	expose	VBZ
cord-344093-3bniy5b5	223	4	a	a	DT
cord-344093-3bniy5b5	223	5	second	second	JJ
cord-344093-3bniy5b5	223	6	functional	functional	JJ
cord-344093-3bniy5b5	223	7	domain	domain	NN
cord-344093-3bniy5b5	223	8	of	of	IN
cord-344093-3bniy5b5	223	9	FADD	FADD	NNP
cord-344093-3bniy5b5	223	10	,	,	,
cord-344093-3bniy5b5	223	11	the	the	DT
cord-344093-3bniy5b5	223	12	death	death	NN
cord-344093-3bniy5b5	223	13	effector	effector	NN
cord-344093-3bniy5b5	223	14	domain	domain	NN
cord-344093-3bniy5b5	223	15	that	that	WDT
cord-344093-3bniy5b5	223	16	is	be	VBZ
cord-344093-3bniy5b5	223	17	directly	directly	RB
cord-344093-3bniy5b5	223	18	able	able	JJ
cord-344093-3bniy5b5	223	19	to	to	TO
cord-344093-3bniy5b5	223	20	recruit	recruit	VB
cord-344093-3bniy5b5	223	21	pro	pro	JJ
cord-344093-3bniy5b5	223	22	-	-	JJ
cord-344093-3bniy5b5	223	23	caspase-8	caspase-8	JJ
cord-344093-3bniy5b5	223	24	FiGURe	FiGURe	NNP
cord-344093-3bniy5b5	223	25	2	2	CD
cord-344093-3bniy5b5	223	26	|	|	NNP
cord-344093-3bniy5b5	223	27	TRAiL	TRAiL	NNP
cord-344093-3bniy5b5	223	28	/	/	SYM
cord-344093-3bniy5b5	223	29	DR5-mediated	dr5-mediate	VBD
cord-344093-3bniy5b5	223	30	cellular	cellular	JJ
cord-344093-3bniy5b5	223	31	signaling	signal	VBG
cord-344093-3bniy5b5	223	32	pathways	pathway	NNS
cord-344093-3bniy5b5	223	33	.	.	.
cord-344093-3bniy5b5	224	1	In	in	IN
cord-344093-3bniy5b5	224	2	presence	presence	NN
cord-344093-3bniy5b5	224	3	of	of	IN
cord-344093-3bniy5b5	224	4	RIP1	RIP1	NNP
cord-344093-3bniy5b5	224	5	,	,	,
cord-344093-3bniy5b5	224	6	TRADD	TRADD	NNP
cord-344093-3bniy5b5	224	7	,	,	,
cord-344093-3bniy5b5	224	8	and	and	CC
cord-344093-3bniy5b5	224	9	FADD	FADD	NNP
cord-344093-3bniy5b5	224	10	,	,	,
cord-344093-3bniy5b5	224	11	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	224	12	ligation	ligation	NN
cord-344093-3bniy5b5	224	13	to	to	IN
cord-344093-3bniy5b5	224	14	DR5	DR5	NNP
cord-344093-3bniy5b5	224	15	results	result	NNS
cord-344093-3bniy5b5	224	16	in	in	IN
cord-344093-3bniy5b5	224	17	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	224	18	induction	induction	NN
cord-344093-3bniy5b5	224	19	,	,	,
cord-344093-3bniy5b5	224	20	which	which	WDT
cord-344093-3bniy5b5	224	21	is	be	VBZ
cord-344093-3bniy5b5	224	22	initiated	initiate	VBN
cord-344093-3bniy5b5	224	23	by	by	IN
cord-344093-3bniy5b5	224	24	recruitment	recruitment	NN
cord-344093-3bniy5b5	224	25	of	of	IN
cord-344093-3bniy5b5	224	26	the	the	DT
cord-344093-3bniy5b5	224	27	pro	pro	JJ
cord-344093-3bniy5b5	224	28	-	-	JJ
cord-344093-3bniy5b5	224	29	caspase-8	caspase-8	JJ
cord-344093-3bniy5b5	224	30	or	or	CC
cord-344093-3bniy5b5	224	31	-10	-10	NN
cord-344093-3bniy5b5	224	32	to	to	IN
cord-344093-3bniy5b5	224	33	FADD	FADD	NNP
cord-344093-3bniy5b5	224	34	.	.	.
cord-344093-3bniy5b5	225	1	These	these	DT
cord-344093-3bniy5b5	225	2	in	in	IN
cord-344093-3bniy5b5	225	3	turn	turn	NN
cord-344093-3bniy5b5	225	4	activate	activate	VBP
cord-344093-3bniy5b5	225	5	the	the	DT
cord-344093-3bniy5b5	225	6	effector	effector	NN
cord-344093-3bniy5b5	225	7	caspases-3	caspases-3	NNP
cord-344093-3bniy5b5	226	1	and	and	CC
cord-344093-3bniy5b5	226	2	-7	-7	NNP
cord-344093-3bniy5b5	226	3	,	,	,
cord-344093-3bniy5b5	226	4	which	which	WDT
cord-344093-3bniy5b5	226	5	leads	lead	VBZ
cord-344093-3bniy5b5	226	6	to	to	IN
cord-344093-3bniy5b5	226	7	DNA	dna	NN
cord-344093-3bniy5b5	226	8	fragmentation	fragmentation	NN
cord-344093-3bniy5b5	226	9	and	and	CC
cord-344093-3bniy5b5	226	10	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	226	11	induction	induction	NN
cord-344093-3bniy5b5	226	12	.	.	.
cord-344093-3bniy5b5	227	1	In	in	IN
cord-344093-3bniy5b5	227	2	addition	addition	NN
cord-344093-3bniy5b5	227	3	,	,	,
cord-344093-3bniy5b5	227	4	TRADD	TRADD	NNP
cord-344093-3bniy5b5	227	5	can	can	MD
cord-344093-3bniy5b5	227	6	trigger	trigger	VB
cord-344093-3bniy5b5	227	7	a	a	DT
cord-344093-3bniy5b5	227	8	TRAF2-and	traf2-and	JJ
cord-344093-3bniy5b5	227	9	JNK	JNK	NNP
cord-344093-3bniy5b5	227	10	-	-	HYPH
cord-344093-3bniy5b5	227	11	dependent	dependent	JJ
cord-344093-3bniy5b5	227	12	activation	activation	NN
cord-344093-3bniy5b5	227	13	of	of	IN
cord-344093-3bniy5b5	227	14	Bax	Bax	NNP
cord-344093-3bniy5b5	227	15	and	and	CC
cord-344093-3bniy5b5	227	16	subsequent	subsequent	JJ
cord-344093-3bniy5b5	227	17	release	release	NN
cord-344093-3bniy5b5	227	18	of	of	IN
cord-344093-3bniy5b5	227	19	mitochondrial	mitochondrial	JJ
cord-344093-3bniy5b5	227	20	cytochrome	cytochrome	NN
cord-344093-3bniy5b5	227	21	c	c	NN
cord-344093-3bniy5b5	227	22	,	,	,
cord-344093-3bniy5b5	227	23	inducing	induce	VBG
cord-344093-3bniy5b5	227	24	the	the	DT
cord-344093-3bniy5b5	227	25	pro	pro	JJ
cord-344093-3bniy5b5	227	26	-	-	JJ
cord-344093-3bniy5b5	227	27	caspase-9	caspase-9	NNP
cord-344093-3bniy5b5	227	28	activation	activation	NN
cord-344093-3bniy5b5	227	29	.	.	.
cord-344093-3bniy5b5	228	1	In	in	IN
cord-344093-3bniy5b5	228	2	the	the	DT
cord-344093-3bniy5b5	228	3	presence	presence	NN
cord-344093-3bniy5b5	228	4	of	of	IN
cord-344093-3bniy5b5	228	5	CYLD	CYLD	NNP
cord-344093-3bniy5b5	228	6	,	,	,
cord-344093-3bniy5b5	228	7	c	c	NNP
cord-344093-3bniy5b5	228	8	-	-	:
cord-344093-3bniy5b5	228	9	FLIP	flip	NN
cord-344093-3bniy5b5	228	10	or	or	CC
cord-344093-3bniy5b5	228	11	absence	absence	NN
cord-344093-3bniy5b5	228	12	of	of	IN
cord-344093-3bniy5b5	228	13	sufficient	sufficient	JJ
cord-344093-3bniy5b5	228	14	amounts	amount	NNS
cord-344093-3bniy5b5	228	15	of	of	IN
cord-344093-3bniy5b5	228	16	FADD	FADD	NNP
cord-344093-3bniy5b5	228	17	or	or	CC
cord-344093-3bniy5b5	228	18	pro	pro	NNP
cord-344093-3bniy5b5	228	19	-	-	JJ
cord-344093-3bniy5b5	228	20	caspase-8	caspase-8	JJ
cord-344093-3bniy5b5	228	21	,	,	,
cord-344093-3bniy5b5	228	22	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	228	23	ligation	ligation	NN
cord-344093-3bniy5b5	228	24	to	to	IN
cord-344093-3bniy5b5	228	25	DR	DR	NNP
cord-344093-3bniy5b5	228	26	triggers	trigger	VBZ
cord-344093-3bniy5b5	228	27	the	the	DT
cord-344093-3bniy5b5	228	28	interaction	interaction	NN
cord-344093-3bniy5b5	228	29	of	of	IN
cord-344093-3bniy5b5	228	30	RIP1	RIP1	NNP
cord-344093-3bniy5b5	228	31	and	and	CC
cord-344093-3bniy5b5	228	32	RIP3	RIP3	NNP
cord-344093-3bniy5b5	228	33	kinase	kinase	NN
cord-344093-3bniy5b5	228	34	,	,	,
cord-344093-3bniy5b5	228	35	which	which	WDT
cord-344093-3bniy5b5	228	36	in	in	IN
cord-344093-3bniy5b5	228	37	turn	turn	NN
cord-344093-3bniy5b5	228	38	cause	cause	VBP
cord-344093-3bniy5b5	228	39	cell	cell	NN
cord-344093-3bniy5b5	228	40	death	death	NN
cord-344093-3bniy5b5	228	41	via	via	IN
cord-344093-3bniy5b5	228	42	induction	induction	NN
cord-344093-3bniy5b5	228	43	of	of	IN
cord-344093-3bniy5b5	228	44	MLKL	MLKL	NNP
cord-344093-3bniy5b5	229	1	and/or	and/or	CC
cord-344093-3bniy5b5	229	2	PARP-1	PARP-1	NNS
cord-344093-3bniy5b5	229	3	.	.	.
cord-344093-3bniy5b5	230	1	In	in	IN
cord-344093-3bniy5b5	230	2	the	the	DT
cord-344093-3bniy5b5	230	3	presence	presence	NN
cord-344093-3bniy5b5	230	4	of	of	IN
cord-344093-3bniy5b5	230	5	cIAPS	cIAPS	NNP
cord-344093-3bniy5b5	230	6	,	,	,
cord-344093-3bniy5b5	230	7	FADD	FADD	NNP
cord-344093-3bniy5b5	230	8	is	be	VBZ
cord-344093-3bniy5b5	230	9	not	not	RB
cord-344093-3bniy5b5	230	10	recruited	recruit	VBN
cord-344093-3bniy5b5	230	11	to	to	IN
cord-344093-3bniy5b5	230	12	DR5	DR5	NNP
cord-344093-3bniy5b5	230	13	upon	upon	IN
cord-344093-3bniy5b5	230	14	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	230	15	ligation	ligation	NN
cord-344093-3bniy5b5	230	16	,	,	,
cord-344093-3bniy5b5	230	17	and	and	CC
cord-344093-3bniy5b5	230	18	TAK1	TAK1	NNP
cord-344093-3bniy5b5	230	19	is	be	VBZ
cord-344093-3bniy5b5	230	20	activated	activate	VBN
cord-344093-3bniy5b5	230	21	by	by	IN
cord-344093-3bniy5b5	230	22	TRADD	TRADD	NNP
cord-344093-3bniy5b5	230	23	/	/	SYM
cord-344093-3bniy5b5	230	24	TRAF2	TRAF2	NNP
cord-344093-3bniy5b5	230	25	interactions	interaction	NNS
cord-344093-3bniy5b5	230	26	.	.	.
cord-344093-3bniy5b5	231	1	TAK1	TAK1	NNP
cord-344093-3bniy5b5	231	2	induces	induce	VBZ
cord-344093-3bniy5b5	231	3	NEMO	NEMO	NNP
cord-344093-3bniy5b5	231	4	followed	follow	VBD
cord-344093-3bniy5b5	231	5	by	by	IN
cord-344093-3bniy5b5	231	6	IκB	iκb	JJ
cord-344093-3bniy5b5	231	7	degradation	degradation	NN
cord-344093-3bniy5b5	231	8	and	and	CC
cord-344093-3bniy5b5	231	9	NFκB	NFκB	NNP
cord-344093-3bniy5b5	231	10	activation	activation	NN
cord-344093-3bniy5b5	231	11	,	,	,
cord-344093-3bniy5b5	231	12	as	as	RB
cord-344093-3bniy5b5	231	13	well	well	RB
cord-344093-3bniy5b5	231	14	as	as	IN
cord-344093-3bniy5b5	231	15	MKK	MKK	NNP
cord-344093-3bniy5b5	231	16	and	and	CC
cord-344093-3bniy5b5	231	17	JNK	JNK	NNP
cord-344093-3bniy5b5	231	18	activation	activation	NN
cord-344093-3bniy5b5	231	19	leading	lead	VBG
cord-344093-3bniy5b5	231	20	to	to	IN
cord-344093-3bniy5b5	231	21	AP-1	AP-1	NNP
cord-344093-3bniy5b5	231	22	nuclear	nuclear	JJ
cord-344093-3bniy5b5	231	23	translocation	translocation	NN
cord-344093-3bniy5b5	231	24	;	;	:
cord-344093-3bniy5b5	231	25	both	both	DT
cord-344093-3bniy5b5	231	26	events	event	NNS
cord-344093-3bniy5b5	231	27	promote	promote	VBP
cord-344093-3bniy5b5	231	28	the	the	DT
cord-344093-3bniy5b5	231	29	production	production	NN
cord-344093-3bniy5b5	231	30	of	of	IN
cord-344093-3bniy5b5	231	31	cytoprotective	cytoprotective	JJ
cord-344093-3bniy5b5	231	32	factors	factor	NNS
cord-344093-3bniy5b5	231	33	such	such	JJ
cord-344093-3bniy5b5	231	34	as	as	IN
cord-344093-3bniy5b5	231	35	XIAP	XIAP	NNP
cord-344093-3bniy5b5	231	36	,	,	,
cord-344093-3bniy5b5	231	37	cIAPs	ciaps	ADD
cord-344093-3bniy5b5	231	38	,	,	,
cord-344093-3bniy5b5	231	39	and	and	CC
cord-344093-3bniy5b5	231	40	c	c	LS
cord-344093-3bniy5b5	231	41	-	-	:
cord-344093-3bniy5b5	231	42	FLIP	FLIP	NNP
cord-344093-3bniy5b5	231	43	.	.	.
cord-344093-3bniy5b5	232	1	Additionally	additionally	RB
cord-344093-3bniy5b5	232	2	,	,	,
cord-344093-3bniy5b5	232	3	TAK1	TAK1	NNP
cord-344093-3bniy5b5	232	4	triggers	trigger	VBZ
cord-344093-3bniy5b5	232	5	AMPK	AMPK	NNP
cord-344093-3bniy5b5	232	6	activation	activation	NN
cord-344093-3bniy5b5	232	7	and	and	CC
cord-344093-3bniy5b5	232	8	thus	thus	RB
cord-344093-3bniy5b5	232	9	mTORC	mtorc	JJ
cord-344093-3bniy5b5	232	10	inhibition	inhibition	NN
cord-344093-3bniy5b5	232	11	,	,	,
cord-344093-3bniy5b5	232	12	which	which	WDT
cord-344093-3bniy5b5	232	13	results	result	VBZ
cord-344093-3bniy5b5	232	14	in	in	IN
cord-344093-3bniy5b5	232	15	enhanced	enhance	VBN
cord-344093-3bniy5b5	232	16	autophagic	autophagic	NN
cord-344093-3bniy5b5	232	17	activity	activity	NN
cord-344093-3bniy5b5	232	18	.	.	.
cord-344093-3bniy5b5	233	1	Abbreviations	abbreviation	NNS
cord-344093-3bniy5b5	233	2	:	:	:
cord-344093-3bniy5b5	234	1	AP-1	AP-1	NNP
cord-344093-3bniy5b5	234	2	,	,	,
cord-344093-3bniy5b5	234	3	activator	activator	NN
cord-344093-3bniy5b5	234	4	protein	protein	NN
cord-344093-3bniy5b5	234	5	1	1	CD
cord-344093-3bniy5b5	234	6	;	;	:
cord-344093-3bniy5b5	234	7	TNF	TNF	NNP
cord-344093-3bniy5b5	234	8	,	,	,
cord-344093-3bniy5b5	234	9	tumor	tumor	NN
cord-344093-3bniy5b5	234	10	necrosis	necrosis	NN
cord-344093-3bniy5b5	234	11	factor	factor	NN
cord-344093-3bniy5b5	234	12	;	;	:
cord-344093-3bniy5b5	234	13	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	234	14	,	,	,
cord-344093-3bniy5b5	234	15	TNF	TNF	NNP
cord-344093-3bniy5b5	234	16	-	-	HYPH
cord-344093-3bniy5b5	234	17	related	relate	VBN
cord-344093-3bniy5b5	234	18	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	234	19	-	-	HYPH
cord-344093-3bniy5b5	234	20	inducing	induce	VBG
cord-344093-3bniy5b5	234	21	ligand	ligand	NN
cord-344093-3bniy5b5	234	22	;	;	:
cord-344093-3bniy5b5	234	23	DR5	DR5	NNP
cord-344093-3bniy5b5	234	24	,	,	,
cord-344093-3bniy5b5	234	25	death	death	NN
cord-344093-3bniy5b5	234	26	receptor	receptor	NN
cord-344093-3bniy5b5	234	27	5	5	CD
cord-344093-3bniy5b5	234	28	;	;	:
cord-344093-3bniy5b5	234	29	RIP1	rip1	NN
cord-344093-3bniy5b5	234	30	,	,	,
cord-344093-3bniy5b5	234	31	receptor	receptor	NN
cord-344093-3bniy5b5	234	32	-	-	HYPH
cord-344093-3bniy5b5	234	33	interacting	interact	VBG
cord-344093-3bniy5b5	234	34	serine	serine	NN
cord-344093-3bniy5b5	234	35	/	/	SYM
cord-344093-3bniy5b5	234	36	threonine	threonine	NN
cord-344093-3bniy5b5	234	37	-	-	HYPH
cord-344093-3bniy5b5	234	38	protein	protein	NN
cord-344093-3bniy5b5	234	39	kinase	kinase	NN
cord-344093-3bniy5b5	234	40	1	1	CD
cord-344093-3bniy5b5	234	41	;	;	:
cord-344093-3bniy5b5	234	42	TRADD	TRADD	NNP
cord-344093-3bniy5b5	234	43	,	,	,
cord-344093-3bniy5b5	234	44	TNF	TNF	NNP
cord-344093-3bniy5b5	234	45	receptor	receptor	NN
cord-344093-3bniy5b5	234	46	type	type	NN
cord-344093-3bniy5b5	234	47	1-associated	1-associated	CD
cord-344093-3bniy5b5	234	48	death	death	NN
cord-344093-3bniy5b5	234	49	protein	protein	NN
cord-344093-3bniy5b5	234	50	;	;	:
cord-344093-3bniy5b5	234	51	FADD	FADD	NNP
cord-344093-3bniy5b5	234	52	,	,	,
cord-344093-3bniy5b5	234	53	Fas	Fas	NNP
cord-344093-3bniy5b5	234	54	-	-	HYPH
cord-344093-3bniy5b5	234	55	associated	associate	VBN
cord-344093-3bniy5b5	234	56	protein	protein	NN
cord-344093-3bniy5b5	234	57	with	with	IN
cord-344093-3bniy5b5	234	58	death	death	NN
cord-344093-3bniy5b5	234	59	domain	domain	NN
cord-344093-3bniy5b5	234	60	;	;	:
cord-344093-3bniy5b5	234	61	TRAF	TRAF	NNP
cord-344093-3bniy5b5	234	62	,	,	,
cord-344093-3bniy5b5	234	63	TNF	TNF	NNP
cord-344093-3bniy5b5	234	64	receptor	receptor	NN
cord-344093-3bniy5b5	234	65	-	-	HYPH
cord-344093-3bniy5b5	234	66	associated	associate	VBN
cord-344093-3bniy5b5	234	67	protein	protein	NN
cord-344093-3bniy5b5	234	68	;	;	:
cord-344093-3bniy5b5	234	69	JNK	JNK	NNP
cord-344093-3bniy5b5	234	70	,	,	,
cord-344093-3bniy5b5	234	71	Janus	Janus	NNP
cord-344093-3bniy5b5	234	72	kinase	kinase	VBZ
cord-344093-3bniy5b5	234	73	;	;	:
cord-344093-3bniy5b5	234	74	Bax	Bax	NNP
cord-344093-3bniy5b5	234	75	,	,	,
cord-344093-3bniy5b5	234	76	Bcl-2-associated	Bcl-2-associated	NNP
cord-344093-3bniy5b5	234	77	X	X	NNP
cord-344093-3bniy5b5	234	78	protein	protein	NN
cord-344093-3bniy5b5	234	79	;	;	:
cord-344093-3bniy5b5	234	80	c	c	LS
cord-344093-3bniy5b5	234	81	-	-	:
cord-344093-3bniy5b5	234	82	FLIP	FLIP	NNP
cord-344093-3bniy5b5	234	83	,	,	,
cord-344093-3bniy5b5	234	84	cellular	cellular	JJ
cord-344093-3bniy5b5	234	85	FADD	FADD	NNP
cord-344093-3bniy5b5	234	86	-	-	HYPH
cord-344093-3bniy5b5	234	87	like	like	JJ
cord-344093-3bniy5b5	234	88	IL-1β	il-1β	RB
cord-344093-3bniy5b5	234	89	-	-	HYPH
cord-344093-3bniy5b5	234	90	converting	convert	VBG
cord-344093-3bniy5b5	234	91	enzyme	enzyme	NN
cord-344093-3bniy5b5	234	92	-	-	HYPH
cord-344093-3bniy5b5	234	93	inhibitory	inhibitory	JJ
cord-344093-3bniy5b5	234	94	proteins	protein	NNS
cord-344093-3bniy5b5	234	95	;	;	:
cord-344093-3bniy5b5	234	96	RIP	rip	NN
cord-344093-3bniy5b5	234	97	,	,	,
cord-344093-3bniy5b5	234	98	receptor	receptor	NN
cord-344093-3bniy5b5	234	99	-	-	HYPH
cord-344093-3bniy5b5	234	100	interacting	interact	VBG
cord-344093-3bniy5b5	234	101	serine	serine	NN
cord-344093-3bniy5b5	234	102	/	/	SYM
cord-344093-3bniy5b5	234	103	threonine	threonine	NN
cord-344093-3bniy5b5	234	104	-	-	HYPH
cord-344093-3bniy5b5	234	105	protein	protein	NN
cord-344093-3bniy5b5	234	106	;	;	:
cord-344093-3bniy5b5	234	107	MLKL	MLKL	NNP
cord-344093-3bniy5b5	234	108	,	,	,
cord-344093-3bniy5b5	234	109	mixed	mixed	JJ
cord-344093-3bniy5b5	234	110	lineage	lineage	NN
cord-344093-3bniy5b5	234	111	kinase	kinase	NN
cord-344093-3bniy5b5	234	112	domain	domain	NN
cord-344093-3bniy5b5	234	113	-	-	HYPH
cord-344093-3bniy5b5	234	114	like	like	JJ
cord-344093-3bniy5b5	234	115	;	;	:
cord-344093-3bniy5b5	234	116	PARP-1	parp-1	JJ
cord-344093-3bniy5b5	234	117	,	,	,
cord-344093-3bniy5b5	234	118	poly	poly	JJ
cord-344093-3bniy5b5	234	119	-	-	HYPH
cord-344093-3bniy5b5	234	120	ADP	adp	NN
cord-344093-3bniy5b5	234	121	-	-	HYPH
cord-344093-3bniy5b5	234	122	ribose	ribose	NN
cord-344093-3bniy5b5	234	123	(	(	-LRB-
cord-344093-3bniy5b5	234	124	PAR	PAR	NNP
cord-344093-3bniy5b5	234	125	)	)	-RRB-
cord-344093-3bniy5b5	234	126	polymerase	polymerase	NN
cord-344093-3bniy5b5	234	127	1	1	CD
cord-344093-3bniy5b5	234	128	;	;	:
cord-344093-3bniy5b5	234	129	cIAP	cIAP	NNP
cord-344093-3bniy5b5	234	130	,	,	,
cord-344093-3bniy5b5	234	131	cytoprotective	cytoprotective	JJ
cord-344093-3bniy5b5	234	132	factors	factor	NNS
cord-344093-3bniy5b5	234	133	including	include	VBG
cord-344093-3bniy5b5	234	134	inhibition	inhibition	NN
cord-344093-3bniy5b5	234	135	of	of	IN
cord-344093-3bniy5b5	234	136	the	the	DT
cord-344093-3bniy5b5	234	137	autophagic	autophagic	NNP
cord-344093-3bniy5b5	234	138	machinery	machinery	NN
cord-344093-3bniy5b5	234	139	;	;	:
cord-344093-3bniy5b5	234	140	XIAP	XIAP	NNP
cord-344093-3bniy5b5	234	141	,	,	,
cord-344093-3bniy5b5	234	142	X	x	NN
cord-344093-3bniy5b5	234	143	-	-	HYPH
cord-344093-3bniy5b5	234	144	linked	link	VBN
cord-344093-3bniy5b5	234	145	inhibitor	inhibitor	NN
cord-344093-3bniy5b5	234	146	of	of	IN
cord-344093-3bniy5b5	234	147	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	234	148	protein	protein	NN
cord-344093-3bniy5b5	234	149	;	;	:
cord-344093-3bniy5b5	234	150	AMPK	AMPK	NNP
cord-344093-3bniy5b5	234	151	,	,	,
cord-344093-3bniy5b5	234	152	AMP	AMP	NNP
cord-344093-3bniy5b5	234	153	-	-	HYPH
cord-344093-3bniy5b5	234	154	activated	activate	VBN
cord-344093-3bniy5b5	234	155	protein	protein	NN
cord-344093-3bniy5b5	234	156	kinase	kinase	NN
cord-344093-3bniy5b5	234	157	;	;	:
cord-344093-3bniy5b5	234	158	mTORC	mtorc	JJ
cord-344093-3bniy5b5	234	159	,	,	,
cord-344093-3bniy5b5	234	160	mammalian	mammalian	JJ
cord-344093-3bniy5b5	234	161	target	target	NN
cord-344093-3bniy5b5	234	162	of	of	IN
cord-344093-3bniy5b5	234	163	rapamycin	rapamycin	NN
cord-344093-3bniy5b5	234	164	complex	complex	NN
cord-344093-3bniy5b5	234	165	;	;	:
cord-344093-3bniy5b5	234	166	TRAF2	traf2	ADD
cord-344093-3bniy5b5	234	167	,	,	,
cord-344093-3bniy5b5	235	1	TNF	TNF	NNP
cord-344093-3bniy5b5	235	2	receptor	receptor	NN
cord-344093-3bniy5b5	235	3	-	-	HYPH
cord-344093-3bniy5b5	235	4	associated	associate	VBN
cord-344093-3bniy5b5	235	5	protein	protein	NN
cord-344093-3bniy5b5	235	6	2	2	CD
cord-344093-3bniy5b5	235	7	;	;	:
cord-344093-3bniy5b5	235	8	MKK	MKK	NNP
cord-344093-3bniy5b5	235	9	,	,	,
cord-344093-3bniy5b5	235	10	mitogen	mitogen	NN
cord-344093-3bniy5b5	235	11	-	-	HYPH
cord-344093-3bniy5b5	235	12	activated	activate	VBN
cord-344093-3bniy5b5	235	13	protein	protein	NN
cord-344093-3bniy5b5	235	14	kinase	kinase	NN
cord-344093-3bniy5b5	235	15	.	.	.
cord-344093-3bniy5b5	236	1	and	and	CC
cord-344093-3bniy5b5	236	2	pro	pro	JJ
cord-344093-3bniy5b5	236	3	-	-	NN
cord-344093-3bniy5b5	236	4	caspase-10	caspase-10	JJ
cord-344093-3bniy5b5	236	5	.	.	.
cord-344093-3bniy5b5	237	1	How	how	WRB
cord-344093-3bniy5b5	237	2	exactly	exactly	RB
cord-344093-3bniy5b5	237	3	DISC	disc	NN
cord-344093-3bniy5b5	237	4	formation	formation	NN
cord-344093-3bniy5b5	237	5	induces	induce	VBZ
cord-344093-3bniy5b5	237	6	caspase	caspase	NN
cord-344093-3bniy5b5	237	7	activation	activation	NN
cord-344093-3bniy5b5	237	8	is	be	VBZ
cord-344093-3bniy5b5	237	9	still	still	RB
cord-344093-3bniy5b5	237	10	under	under	IN
cord-344093-3bniy5b5	237	11	debate	debate	NN
cord-344093-3bniy5b5	237	12	.	.	.
cord-344093-3bniy5b5	238	1	The	the	DT
cord-344093-3bniy5b5	238	2	most	most	RBS
cord-344093-3bniy5b5	238	3	probable	probable	JJ
cord-344093-3bniy5b5	238	4	scenarios	scenario	NNS
cord-344093-3bniy5b5	238	5	include	include	VBP
cord-344093-3bniy5b5	238	6	either	either	CC
cord-344093-3bniy5b5	238	7	an	an	DT
cord-344093-3bniy5b5	238	8	autocatalytic	autocatalytic	JJ
cord-344093-3bniy5b5	238	9	cleavage	cleavage	NN
cord-344093-3bniy5b5	238	10	of	of	IN
cord-344093-3bniy5b5	238	11	caspase	caspase	NN
cord-344093-3bniy5b5	238	12	-	-	HYPH
cord-344093-3bniy5b5	238	13	pro	pro	JJ
cord-344093-3bniy5b5	238	14	-	-	NNS
cord-344093-3bniy5b5	238	15	domains	domain	NNS
cord-344093-3bniy5b5	238	16	enabled	enable	VBN
cord-344093-3bniy5b5	238	17	by	by	IN
cord-344093-3bniy5b5	238	18	the	the	DT
cord-344093-3bniy5b5	238	19	spatial	spatial	JJ
cord-344093-3bniy5b5	238	20	proximity	proximity	NN
cord-344093-3bniy5b5	238	21	between	between	IN
cord-344093-3bniy5b5	238	22	pro	pro	JJ
cord-344093-3bniy5b5	238	23	-	-	NNS
cord-344093-3bniy5b5	238	24	caspases	caspases	JJ
cord-344093-3bniy5b5	238	25	(	(	-LRB-
cord-344093-3bniy5b5	238	26	generated	generate	VBN
cord-344093-3bniy5b5	238	27	by	by	IN
cord-344093-3bniy5b5	238	28	their	-PRON-	PRP$
cord-344093-3bniy5b5	238	29	recruitment	recruitment	NN
cord-344093-3bniy5b5	238	30	to	to	IN
cord-344093-3bniy5b5	238	31	DISC	disc	VB
cord-344093-3bniy5b5	238	32	)	)	-RRB-
cord-344093-3bniy5b5	238	33	,	,	,
cord-344093-3bniy5b5	238	34	by	by	IN
cord-344093-3bniy5b5	238	35	pro	pro	JJ
cord-344093-3bniy5b5	238	36	-	-	JJ
cord-344093-3bniy5b5	238	37	caspase	caspase	JJ
cord-344093-3bniy5b5	238	38	dimerization	dimerization	NN
cord-344093-3bniy5b5	238	39	,	,	,
cord-344093-3bniy5b5	238	40	or	or	CC
cord-344093-3bniy5b5	238	41	by	by	IN
cord-344093-3bniy5b5	238	42	pro	pro	JJ
cord-344093-3bniy5b5	238	43	-	-	JJ
cord-344093-3bniy5b5	238	44	caspase	caspase	JJ
cord-344093-3bniy5b5	238	45	conformational	conformational	JJ
cord-344093-3bniy5b5	238	46	stabilization	stabilization	NN
cord-344093-3bniy5b5	238	47	(	(	-LRB-
cord-344093-3bniy5b5	238	48	125	125	CD
cord-344093-3bniy5b5	238	49	)	)	-RRB-
cord-344093-3bniy5b5	238	50	.	.	.
cord-344093-3bniy5b5	239	1	Removal	removal	NN
cord-344093-3bniy5b5	239	2	of	of	IN
cord-344093-3bniy5b5	239	3	the	the	DT
cord-344093-3bniy5b5	239	4	pro	pro	JJ
cord-344093-3bniy5b5	239	5	-	-	NN
cord-344093-3bniy5b5	239	6	domain	domain	NN
cord-344093-3bniy5b5	239	7	of	of	IN
cord-344093-3bniy5b5	239	8	caspase-8	caspase-8	NNP
cord-344093-3bniy5b5	239	9	and	and	CC
cord-344093-3bniy5b5	239	10	caspase-10	caspase-10	NN
cord-344093-3bniy5b5	239	11	results	result	NNS
cord-344093-3bniy5b5	239	12	in	in	IN
cord-344093-3bniy5b5	239	13	the	the	DT
cord-344093-3bniy5b5	239	14	activation	activation	NN
cord-344093-3bniy5b5	239	15	of	of	IN
cord-344093-3bniy5b5	239	16	the	the	DT
cord-344093-3bniy5b5	239	17	effector	effector	NN
cord-344093-3bniy5b5	239	18	caspases-3	caspases-3	NNP
cord-344093-3bniy5b5	240	1	and	and	CC
cord-344093-3bniy5b5	240	2	-7	-7	NNP
cord-344093-3bniy5b5	240	3	,	,	,
cord-344093-3bniy5b5	240	4	which	which	WDT
cord-344093-3bniy5b5	240	5	cleave	cleave	VBP
cord-344093-3bniy5b5	240	6	DNA	dna	NN
cord-344093-3bniy5b5	240	7	fragmentation	fragmentation	NN
cord-344093-3bniy5b5	240	8	factor	factor	NN
cord-344093-3bniy5b5	240	9	45	45	CD
cord-344093-3bniy5b5	240	10	and	and	CC
cord-344093-3bniy5b5	240	11	lead	lead	VB
cord-344093-3bniy5b5	240	12	to	to	IN
cord-344093-3bniy5b5	240	13	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	240	14	(	(	-LRB-
cord-344093-3bniy5b5	240	15	142	142	CD
cord-344093-3bniy5b5	240	16	,	,	,
cord-344093-3bniy5b5	240	17	143	143	CD
cord-344093-3bniy5b5	240	18	)	)	-RRB-
cord-344093-3bniy5b5	240	19	.	.	.
cord-344093-3bniy5b5	241	1	Moreover	moreover	RB
cord-344093-3bniy5b5	241	2	,	,	,
cord-344093-3bniy5b5	241	3	TRAILbinding	trailbinde	VBG
cord-344093-3bniy5b5	241	4	to	to	IN
cord-344093-3bniy5b5	241	5	DR4	DR4	NNP
cord-344093-3bniy5b5	241	6	and	and	CC
cord-344093-3bniy5b5	241	7	DR5	DR5	NNP
cord-344093-3bniy5b5	241	8	can	can	MD
cord-344093-3bniy5b5	241	9	induce	induce	VB
cord-344093-3bniy5b5	241	10	the	the	DT
cord-344093-3bniy5b5	241	11	JNK	JNK	NNP
cord-344093-3bniy5b5	241	12	either	either	CC
cord-344093-3bniy5b5	241	13	via	via	IN
cord-344093-3bniy5b5	241	14	caspase-8	caspase-8	NNP
cord-344093-3bniy5b5	241	15	or	or	CC
cord-344093-3bniy5b5	241	16	recruitment	recruitment	NN
cord-344093-3bniy5b5	241	17	of	of	IN
cord-344093-3bniy5b5	241	18	TNF	TNF	NNP
cord-344093-3bniy5b5	241	19	receptor	receptor	NN
cord-344093-3bniy5b5	241	20	-	-	HYPH
cord-344093-3bniy5b5	241	21	associated	associate	VBN
cord-344093-3bniy5b5	241	22	protein	protein	NN
cord-344093-3bniy5b5	241	23	2	2	CD
cord-344093-3bniy5b5	241	24	(	(	-LRB-
cord-344093-3bniy5b5	241	25	TRAF2	TRAF2	NNP
cord-344093-3bniy5b5	241	26	)	)	-RRB-
cord-344093-3bniy5b5	241	27	to	to	IN
cord-344093-3bniy5b5	241	28	the	the	DT
cord-344093-3bniy5b5	241	29	DISC	disc	NN
cord-344093-3bniy5b5	241	30	complex	complex	NN
cord-344093-3bniy5b5	241	31	,	,	,
cord-344093-3bniy5b5	241	32	which	which	WDT
cord-344093-3bniy5b5	241	33	results	result	VBZ
cord-344093-3bniy5b5	241	34	in	in	IN
cord-344093-3bniy5b5	241	35	the	the	DT
cord-344093-3bniy5b5	241	36	activation	activation	NN
cord-344093-3bniy5b5	241	37	of	of	IN
cord-344093-3bniy5b5	241	38	the	the	DT
cord-344093-3bniy5b5	241	39	intrinsic	intrinsic	JJ
cord-344093-3bniy5b5	241	40	apoptotic	apoptotic	JJ
cord-344093-3bniy5b5	241	41	cascade	cascade	NN
cord-344093-3bniy5b5	241	42	by	by	IN
cord-344093-3bniy5b5	241	43	Bax	Bax	NNP
cord-344093-3bniy5b5	241	44	-	-	HYPH
cord-344093-3bniy5b5	241	45	dependent	dependent	JJ
cord-344093-3bniy5b5	241	46	mitochondrial	mitochondrial	JJ
cord-344093-3bniy5b5	241	47	cytochrome	cytochrome	NN
cord-344093-3bniy5b5	241	48	c	c	NN
cord-344093-3bniy5b5	241	49	release	release	NN
cord-344093-3bniy5b5	241	50	(	(	-LRB-
cord-344093-3bniy5b5	241	51	144	144	CD
cord-344093-3bniy5b5	241	52	)	)	-RRB-
cord-344093-3bniy5b5	241	53	.	.	.
cord-344093-3bniy5b5	242	1	In	in	IN
cord-344093-3bniy5b5	242	2	addition	addition	NN
cord-344093-3bniy5b5	242	3	,	,	,
cord-344093-3bniy5b5	242	4	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	242	5	signaling	signaling	NN
cord-344093-3bniy5b5	242	6	is	be	VBZ
cord-344093-3bniy5b5	242	7	also	also	RB
cord-344093-3bniy5b5	242	8	able	able	JJ
cord-344093-3bniy5b5	242	9	to	to	TO
cord-344093-3bniy5b5	242	10	induce	induce	VB
cord-344093-3bniy5b5	242	11	necroptosis	necroptosis	NN
cord-344093-3bniy5b5	242	12	by	by	IN
cord-344093-3bniy5b5	242	13	both	both	CC
cord-344093-3bniy5b5	242	14	activating	activate	VBG
cord-344093-3bniy5b5	242	15	the	the	DT
cord-344093-3bniy5b5	242	16	RIP1	RIP1	NNP
cord-344093-3bniy5b5	242	17	/	/	SYM
cord-344093-3bniy5b5	242	18	RIP3	RIP3	NNS
cord-344093-3bniy5b5	242	19	kinase	kinase	NN
cord-344093-3bniy5b5	242	20	downstream	downstream	JJ
cord-344093-3bniy5b5	242	21	effectors	effector	NNS
cord-344093-3bniy5b5	242	22	PARP-1	PARP-1	NNS
cord-344093-3bniy5b5	242	23	and	and	CC
cord-344093-3bniy5b5	242	24	MLKL	MLKL	NNP
cord-344093-3bniy5b5	242	25	,	,	,
cord-344093-3bniy5b5	242	26	contributing	contribute	VBG
cord-344093-3bniy5b5	242	27	to	to	IN
cord-344093-3bniy5b5	242	28	epithelial	epithelial	JJ
cord-344093-3bniy5b5	242	29	cell	cell	NN
cord-344093-3bniy5b5	242	30	death	death	NN
cord-344093-3bniy5b5	242	31	and	and	CC
cord-344093-3bniy5b5	242	32	tissue	tissue	NN
cord-344093-3bniy5b5	242	33	injury	injury	NN
cord-344093-3bniy5b5	242	34	(	(	-LRB-
cord-344093-3bniy5b5	242	35	145	145	CD
cord-344093-3bniy5b5	242	36	)	)	-RRB-
cord-344093-3bniy5b5	242	37	(	(	-LRB-
cord-344093-3bniy5b5	242	38	146	146	CD
cord-344093-3bniy5b5	242	39	)	)	-RRB-
cord-344093-3bniy5b5	242	40	(	(	-LRB-
cord-344093-3bniy5b5	242	41	147	147	CD
cord-344093-3bniy5b5	242	42	)	)	-RRB-
cord-344093-3bniy5b5	242	43	.	.	.
cord-344093-3bniy5b5	243	1	It	-PRON-	PRP
cord-344093-3bniy5b5	243	2	has	have	VBZ
cord-344093-3bniy5b5	243	3	become	become	VBN
cord-344093-3bniy5b5	243	4	apparent	apparent	JJ
cord-344093-3bniy5b5	243	5	in	in	IN
cord-344093-3bniy5b5	243	6	recent	recent	JJ
cord-344093-3bniy5b5	243	7	years	year	NNS
cord-344093-3bniy5b5	243	8	that	that	WDT
cord-344093-3bniy5b5	243	9	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	243	10	signaling	signaling	NN
cord-344093-3bniy5b5	243	11	is	be	VBZ
cord-344093-3bniy5b5	243	12	closely	closely	RB
cord-344093-3bniy5b5	243	13	linked	link	VBN
cord-344093-3bniy5b5	243	14	to	to	IN
cord-344093-3bniy5b5	243	15	induction	induction	NN
cord-344093-3bniy5b5	243	16	of	of	IN
cord-344093-3bniy5b5	243	17	autophagy	autophagy	NN
cord-344093-3bniy5b5	243	18	,	,	,
cord-344093-3bniy5b5	243	19	a	a	DT
cord-344093-3bniy5b5	243	20	process	process	NN
cord-344093-3bniy5b5	243	21	generally	generally	RB
cord-344093-3bniy5b5	243	22	associated	associate	VBN
cord-344093-3bniy5b5	243	23	with	with	IN
cord-344093-3bniy5b5	243	24	the	the	DT
cord-344093-3bniy5b5	243	25	blockade	blockade	NN
cord-344093-3bniy5b5	243	26	of	of	IN
cord-344093-3bniy5b5	243	27	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	243	28	and	and	CC
cord-344093-3bniy5b5	243	29	necrosis	necrosis	NN
cord-344093-3bniy5b5	243	30	.	.	.
cord-344093-3bniy5b5	244	1	Indeed	indeed	RB
cord-344093-3bniy5b5	244	2	,	,	,
cord-344093-3bniy5b5	244	3	autophagy	autophagy	NN
cord-344093-3bniy5b5	244	4	has	have	VBZ
cord-344093-3bniy5b5	244	5	been	be	VBN
cord-344093-3bniy5b5	244	6	reported	report	VBN
cord-344093-3bniy5b5	244	7	to	to	TO
cord-344093-3bniy5b5	244	8	improve	improve	VB
cord-344093-3bniy5b5	244	9	cellular	cellular	JJ
cord-344093-3bniy5b5	244	10	survival	survival	NN
cord-344093-3bniy5b5	244	11	in	in	IN
cord-344093-3bniy5b5	244	12	cell	cell	NN
cord-344093-3bniy5b5	244	13	stress	stress	NN
cord-344093-3bniy5b5	244	14	by	by	IN
cord-344093-3bniy5b5	244	15	catabolic	catabolic	JJ
cord-344093-3bniy5b5	244	16	removal	removal	NN
cord-344093-3bniy5b5	244	17	of	of	IN
cord-344093-3bniy5b5	244	18	cytoplasmic	cytoplasmic	JJ
cord-344093-3bniy5b5	244	19	long	long	RB
cord-344093-3bniy5b5	244	20	-	-	HYPH
cord-344093-3bniy5b5	244	21	lived	live	VBN
cord-344093-3bniy5b5	244	22	proteins	protein	NNS
cord-344093-3bniy5b5	244	23	and	and	CC
cord-344093-3bniy5b5	244	24	damaged	damage	VBN
cord-344093-3bniy5b5	244	25	organelles	organelle	NNS
cord-344093-3bniy5b5	244	26	.	.	.
cord-344093-3bniy5b5	245	1	It	-PRON-	PRP
cord-344093-3bniy5b5	245	2	also	also	RB
cord-344093-3bniy5b5	245	3	contributes	contribute	VBZ
cord-344093-3bniy5b5	245	4	to	to	IN
cord-344093-3bniy5b5	245	5	viral	viral	JJ
cord-344093-3bniy5b5	245	6	clearance	clearance	NN
cord-344093-3bniy5b5	245	7	and	and	CC
cord-344093-3bniy5b5	245	8	the	the	DT
cord-344093-3bniy5b5	245	9	transfer	transfer	NN
cord-344093-3bniy5b5	245	10	of	of	IN
cord-344093-3bniy5b5	245	11	viral	viral	JJ
cord-344093-3bniy5b5	245	12	material	material	NN
cord-344093-3bniy5b5	245	13	to	to	IN
cord-344093-3bniy5b5	245	14	endosomal-/lysosomallocated	endosomal-/lysosomallocated	NNP
cord-344093-3bniy5b5	245	15	TLR7	TLR7	NNP
cord-344093-3bniy5b5	245	16	or	or	CC
cord-344093-3bniy5b5	245	17	MHC	MHC	NNP
cord-344093-3bniy5b5	245	18	class	class	NN
cord-344093-3bniy5b5	245	19	II	II	NNP
cord-344093-3bniy5b5	245	20	compartments	compartment	NNS
cord-344093-3bniy5b5	245	21	for	for	IN
cord-344093-3bniy5b5	245	22	the	the	DT
cord-344093-3bniy5b5	245	23	activation	activation	NN
cord-344093-3bniy5b5	245	24	of	of	IN
cord-344093-3bniy5b5	245	25	adaptive	adaptive	JJ
cord-344093-3bniy5b5	245	26	immunity	immunity	NN
cord-344093-3bniy5b5	245	27	(	(	-LRB-
cord-344093-3bniy5b5	245	28	148	148	CD
cord-344093-3bniy5b5	245	29	)	)	-RRB-
cord-344093-3bniy5b5	245	30	.	.	.
cord-344093-3bniy5b5	246	1	Several	several	JJ
cord-344093-3bniy5b5	246	2	studies	study	NNS
cord-344093-3bniy5b5	246	3	outline	outline	VBP
cord-344093-3bniy5b5	246	4	that	that	WDT
cord-344093-3bniy5b5	246	5	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	246	6	ligation	ligation	NN
cord-344093-3bniy5b5	246	7	to	to	IN
cord-344093-3bniy5b5	246	8	DR5	DR5	NNP
cord-344093-3bniy5b5	246	9	can	can	MD
cord-344093-3bniy5b5	246	10	result	result	VB
cord-344093-3bniy5b5	246	11	in	in	IN
cord-344093-3bniy5b5	246	12	a	a	DT
cord-344093-3bniy5b5	246	13	TRAF2-dependent	traf2-dependent	CD
cord-344093-3bniy5b5	246	14	activation	activation	NN
cord-344093-3bniy5b5	246	15	of	of	IN
cord-344093-3bniy5b5	246	16	TAK1	TAK1	NNP
cord-344093-3bniy5b5	246	17	(	(	-LRB-
cord-344093-3bniy5b5	246	18	MAP3K7	MAP3K7	NNP
cord-344093-3bniy5b5	246	19	)	)	-RRB-
cord-344093-3bniy5b5	246	20	that	that	WDT
cord-344093-3bniy5b5	246	21	has	have	VBZ
cord-344093-3bniy5b5	246	22	been	be	VBN
cord-344093-3bniy5b5	246	23	attributed	attribute	VBN
cord-344093-3bniy5b5	246	24	a	a	DT
cord-344093-3bniy5b5	246	25	central	central	JJ
cord-344093-3bniy5b5	246	26	role	role	NN
cord-344093-3bniy5b5	246	27	in	in	IN
cord-344093-3bniy5b5	246	28	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	246	29	-	-	HYPH
cord-344093-3bniy5b5	246	30	induced	induce	VBN
cord-344093-3bniy5b5	246	31	autophagy	autophagy	NN
cord-344093-3bniy5b5	246	32	activation	activation	NN
cord-344093-3bniy5b5	246	33	(	(	-LRB-
cord-344093-3bniy5b5	246	34	149	149	CD
cord-344093-3bniy5b5	246	35	)	)	-RRB-
cord-344093-3bniy5b5	246	36	.	.	.
cord-344093-3bniy5b5	247	1	TAK1	TAK1	NNP
cord-344093-3bniy5b5	247	2	modulates	modulate	VBZ
cord-344093-3bniy5b5	247	3	the	the	DT
cord-344093-3bniy5b5	247	4	IKK	IKK	NNP
cord-344093-3bniy5b5	247	5	-	-	HYPH
cord-344093-3bniy5b5	247	6	dependent	dependent	JJ
cord-344093-3bniy5b5	247	7	translocation	translocation	NN
cord-344093-3bniy5b5	247	8	of	of	IN
cord-344093-3bniy5b5	247	9	NFκB	NFκB	NNP
cord-344093-3bniy5b5	247	10	,	,	,
cord-344093-3bniy5b5	247	11	and	and	CC
cord-344093-3bniy5b5	247	12	it	-PRON-	PRP
cord-344093-3bniy5b5	247	13	also	also	RB
cord-344093-3bniy5b5	247	14	induces	induce	VBZ
cord-344093-3bniy5b5	247	15	JNK	JNK	NNP
cord-344093-3bniy5b5	247	16	activation	activation	NN
cord-344093-3bniy5b5	247	17	via	via	IN
cord-344093-3bniy5b5	247	18	mitogen	mitogen	NN
cord-344093-3bniy5b5	247	19	-	-	HYPH
cord-344093-3bniy5b5	247	20	activated	activate	VBN
cord-344093-3bniy5b5	247	21	protein	protein	NN
cord-344093-3bniy5b5	247	22	kinase	kinase	NN
cord-344093-3bniy5b5	247	23	.	.	.
cord-344093-3bniy5b5	248	1	Both	both	DT
cord-344093-3bniy5b5	248	2	events	event	NNS
cord-344093-3bniy5b5	248	3	lead	lead	VBP
cord-344093-3bniy5b5	248	4	to	to	IN
cord-344093-3bniy5b5	248	5	expression	expression	NN
cord-344093-3bniy5b5	248	6	of	of	IN
cord-344093-3bniy5b5	248	7	autophagy	autophagy	NN
cord-344093-3bniy5b5	248	8	-	-	HYPH
cord-344093-3bniy5b5	248	9	related	relate	VBN
cord-344093-3bniy5b5	248	10	factors	factor	NNS
cord-344093-3bniy5b5	248	11	including	include	VBG
cord-344093-3bniy5b5	248	12	inhibition	inhibition	NN
cord-344093-3bniy5b5	248	13	of	of	IN
cord-344093-3bniy5b5	248	14	the	the	DT
cord-344093-3bniy5b5	248	15	autophagic	autophagic	NNP
cord-344093-3bniy5b5	248	16	machinery	machinery	NN
cord-344093-3bniy5b5	248	17	(	(	-LRB-
cord-344093-3bniy5b5	249	1	cIAP)1	cIAP)1	NNS
cord-344093-3bniy5b5	249	2	,	,	,
cord-344093-3bniy5b5	249	3	cIAP2	ciap2	XX
cord-344093-3bniy5b5	250	1	,	,	,
cord-344093-3bniy5b5	250	2	X	X	NNS
cord-344093-3bniy5b5	250	3	-	-	HYPH
cord-344093-3bniy5b5	250	4	linked	link	VBN
cord-344093-3bniy5b5	250	5	inhibitor	inhibitor	NN
cord-344093-3bniy5b5	250	6	of	of	IN
cord-344093-3bniy5b5	250	7	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	250	8	protein	protein	NN
cord-344093-3bniy5b5	250	9	,	,	,
cord-344093-3bniy5b5	250	10	and	and	CC
cord-344093-3bniy5b5	250	11	c	c	LS
cord-344093-3bniy5b5	250	12	-	-	:
cord-344093-3bniy5b5	250	13	FLIP	FLIP	NNP
cord-344093-3bniy5b5	250	14	(	(	-LRB-
cord-344093-3bniy5b5	250	15	150	150	CD
cord-344093-3bniy5b5	250	16	,	,	,
cord-344093-3bniy5b5	250	17	151	151	CD
cord-344093-3bniy5b5	250	18	)	)	-RRB-
cord-344093-3bniy5b5	250	19	.	.	.
cord-344093-3bniy5b5	251	1	Especially	especially	RB
cord-344093-3bniy5b5	251	2	,	,	,
cord-344093-3bniy5b5	251	3	c	c	LS
cord-344093-3bniy5b5	251	4	-	-	:
cord-344093-3bniy5b5	251	5	FLIP	FLIP	NNP
cord-344093-3bniy5b5	251	6	has	have	VBZ
cord-344093-3bniy5b5	251	7	been	be	VBN
cord-344093-3bniy5b5	251	8	associated	associate	VBN
cord-344093-3bniy5b5	251	9	with	with	IN
cord-344093-3bniy5b5	251	10	desensitization	desensitization	NN
cord-344093-3bniy5b5	251	11	of	of	IN
cord-344093-3bniy5b5	251	12	cells	cell	NNS
cord-344093-3bniy5b5	251	13	to	to	IN
cord-344093-3bniy5b5	251	14	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	251	15	-	-	HYPH
cord-344093-3bniy5b5	251	16	induced	induce	VBN
cord-344093-3bniy5b5	251	17	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	251	18	,	,	,
cord-344093-3bniy5b5	251	19	favoring	favor	VBG
cord-344093-3bniy5b5	251	20	autophagy	autophagy	NN
cord-344093-3bniy5b5	251	21	-	-	HYPH
cord-344093-3bniy5b5	251	22	related	relate	VBN
cord-344093-3bniy5b5	251	23	cascades	cascade	NNS
cord-344093-3bniy5b5	251	24	(	(	-LRB-
cord-344093-3bniy5b5	251	25	152	152	CD
cord-344093-3bniy5b5	251	26	)	)	-RRB-
cord-344093-3bniy5b5	251	27	.	.	.
cord-344093-3bniy5b5	252	1	Another	another	DT
cord-344093-3bniy5b5	252	2	study	study	NN
cord-344093-3bniy5b5	252	3	revealed	reveal	VBD
cord-344093-3bniy5b5	252	4	that	that	IN
cord-344093-3bniy5b5	252	5	upon	upon	IN
cord-344093-3bniy5b5	252	6	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	252	7	signaling	signal	VBG
cord-344093-3bniy5b5	252	8	the	the	DT
cord-344093-3bniy5b5	252	9	AMP	AMP	NNP
cord-344093-3bniy5b5	252	10	-	-	HYPH
cord-344093-3bniy5b5	252	11	activated	activate	VBN
cord-344093-3bniy5b5	252	12	protein	protein	NN
cord-344093-3bniy5b5	252	13	kinase	kinase	NN
cord-344093-3bniy5b5	252	14	(	(	-LRB-
cord-344093-3bniy5b5	252	15	AMPK	AMPK	NNP
cord-344093-3bniy5b5	252	16	)	)	-RRB-
cord-344093-3bniy5b5	252	17	is	be	VBZ
cord-344093-3bniy5b5	252	18	activated	activate	VBN
cord-344093-3bniy5b5	252	19	.	.	.
cord-344093-3bniy5b5	253	1	AMPK	AMPK	NNP
cord-344093-3bniy5b5	253	2	in	in	IN
cord-344093-3bniy5b5	253	3	turn	turn	NN
cord-344093-3bniy5b5	253	4	inhibits	inhibit	VBZ
cord-344093-3bniy5b5	253	5	the	the	DT
cord-344093-3bniy5b5	253	6	mammalian	mammalian	JJ
cord-344093-3bniy5b5	253	7	target	target	NN
cord-344093-3bniy5b5	253	8	of	of	IN
cord-344093-3bniy5b5	253	9	rapamycin	rapamycin	NN
cord-344093-3bniy5b5	253	10	complex	complex	NN
cord-344093-3bniy5b5	253	11	1	1	CD
cord-344093-3bniy5b5	253	12	that	that	WDT
cord-344093-3bniy5b5	253	13	itself	-PRON-	PRP
cord-344093-3bniy5b5	253	14	is	be	VBZ
cord-344093-3bniy5b5	253	15	an	an	DT
cord-344093-3bniy5b5	253	16	inhibitor	inhibitor	NN
cord-344093-3bniy5b5	253	17	of	of	IN
cord-344093-3bniy5b5	253	18	autophagy	autophagy	NN
cord-344093-3bniy5b5	253	19	,	,	,
cord-344093-3bniy5b5	253	20	thus	thus	RB
cord-344093-3bniy5b5	253	21	the	the	DT
cord-344093-3bniy5b5	253	22	activation	activation	NN
cord-344093-3bniy5b5	253	23	of	of	IN
cord-344093-3bniy5b5	253	24	the	the	DT
cord-344093-3bniy5b5	253	25	autophagic	autophagic	NNP
cord-344093-3bniy5b5	253	26	machinery	machinery	NN
cord-344093-3bniy5b5	253	27	is	be	VBZ
cord-344093-3bniy5b5	253	28	promoted	promote	VBN
cord-344093-3bniy5b5	253	29	(	(	-LRB-
cord-344093-3bniy5b5	253	30	153	153	CD
cord-344093-3bniy5b5	253	31	)	)	-RRB-
cord-344093-3bniy5b5	253	32	.	.	.
cord-344093-3bniy5b5	254	1	The	the	DT
cord-344093-3bniy5b5	254	2	decision	decision	NN
cord-344093-3bniy5b5	254	3	if	if	IN
cord-344093-3bniy5b5	254	4	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	254	5	signaling	signal	VBG
cord-344093-3bniy5b5	254	6	results	result	NNS
cord-344093-3bniy5b5	254	7	rather	rather	RB
cord-344093-3bniy5b5	254	8	in	in	IN
cord-344093-3bniy5b5	254	9	necroptotic	necroptotic	JJ
cord-344093-3bniy5b5	254	10	or	or	CC
cord-344093-3bniy5b5	254	11	apoptotic	apoptotic	JJ
cord-344093-3bniy5b5	254	12	cell	cell	NN
cord-344093-3bniy5b5	254	13	death	death	NN
cord-344093-3bniy5b5	254	14	or	or	CC
cord-344093-3bniy5b5	254	15	in	in	IN
cord-344093-3bniy5b5	254	16	activation	activation	NN
cord-344093-3bniy5b5	254	17	of	of	IN
cord-344093-3bniy5b5	254	18	autophagy	autophagy	NN
cord-344093-3bniy5b5	254	19	seems	seem	VBZ
cord-344093-3bniy5b5	254	20	to	to	TO
cord-344093-3bniy5b5	254	21	be	be	VB
cord-344093-3bniy5b5	254	22	dependent	dependent	JJ
cord-344093-3bniy5b5	254	23	on	on	IN
cord-344093-3bniy5b5	254	24	the	the	DT
cord-344093-3bniy5b5	254	25	presence	presence	NN
cord-344093-3bniy5b5	254	26	of	of	IN
cord-344093-3bniy5b5	254	27	cIAPs	ciaps	ADD
cord-344093-3bniy5b5	254	28	that	that	WDT
cord-344093-3bniy5b5	254	29	promote	promote	VBP
cord-344093-3bniy5b5	254	30	RIP	rip	NN
cord-344093-3bniy5b5	254	31	kinase	kinase	NN
cord-344093-3bniy5b5	254	32	ubiquitination	ubiquitination	NN
cord-344093-3bniy5b5	254	33	and	and	CC
cord-344093-3bniy5b5	254	34	degradation	degradation	NN
cord-344093-3bniy5b5	254	35	(	(	-LRB-
cord-344093-3bniy5b5	254	36	146	146	CD
cord-344093-3bniy5b5	254	37	)	)	-RRB-
cord-344093-3bniy5b5	254	38	,	,	,
cord-344093-3bniy5b5	254	39	but	but	CC
cord-344093-3bniy5b5	254	40	also	also	RB
cord-344093-3bniy5b5	254	41	on	on	IN
cord-344093-3bniy5b5	254	42	the	the	DT
cord-344093-3bniy5b5	254	43	balance	balance	NN
cord-344093-3bniy5b5	254	44	between	between	IN
cord-344093-3bniy5b5	254	45	active	active	JJ
cord-344093-3bniy5b5	254	46	caspases	caspase	NNS
cord-344093-3bniy5b5	254	47	and	and	CC
cord-344093-3bniy5b5	254	48	autophagic	autophagic	NN
cord-344093-3bniy5b5	254	49	proteins	protein	NNS
cord-344093-3bniy5b5	254	50	such	such	JJ
cord-344093-3bniy5b5	254	51	as	as	IN
cord-344093-3bniy5b5	254	52	Beclin-1	Beclin-1	NNP
cord-344093-3bniy5b5	254	53	(	(	-LRB-
cord-344093-3bniy5b5	254	54	154	154	CD
cord-344093-3bniy5b5	254	55	,	,	,
cord-344093-3bniy5b5	254	56	155	155	CD
cord-344093-3bniy5b5	254	57	)	)	-RRB-
cord-344093-3bniy5b5	254	58	.	.	.
cord-344093-3bniy5b5	255	1	This	this	DT
cord-344093-3bniy5b5	255	2	suggests	suggest	VBZ
cord-344093-3bniy5b5	255	3	a	a	DT
cord-344093-3bniy5b5	255	4	scenario	scenario	NN
cord-344093-3bniy5b5	255	5	where	where	WRB
cord-344093-3bniy5b5	255	6	autophagy	autophagy	NN
cord-344093-3bniy5b5	255	7	is	be	VBZ
cord-344093-3bniy5b5	255	8	activated	activate	VBN
cord-344093-3bniy5b5	255	9	as	as	IN
cord-344093-3bniy5b5	255	10	cell	cell	NN
cord-344093-3bniy5b5	255	11	protective	protective	JJ
cord-344093-3bniy5b5	255	12	mechanism	mechanism	NN
cord-344093-3bniy5b5	255	13	until	until	IN
cord-344093-3bniy5b5	255	14	cell	cell	NN
cord-344093-3bniy5b5	255	15	stress	stress	NN
cord-344093-3bniy5b5	255	16	-	-	:
cord-344093-3bniy5b5	255	17	as	as	IN
cord-344093-3bniy5b5	255	18	executed	execute	VBN
cord-344093-3bniy5b5	255	19	by	by	IN
cord-344093-3bniy5b5	255	20	enhanced	enhance	VBN
cord-344093-3bniy5b5	255	21	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	255	22	signaling	signal	VBG
cord-344093-3bniy5b5	255	23	or	or	CC
cord-344093-3bniy5b5	255	24	additional	additional	JJ
cord-344093-3bniy5b5	255	25	viral	viral	JJ
cord-344093-3bniy5b5	255	26	infection	infection	NN
cord-344093-3bniy5b5	255	27	-	-	HYPH
cord-344093-3bniy5b5	255	28	increases	increase	NNS
cord-344093-3bniy5b5	255	29	over	over	IN
cord-344093-3bniy5b5	255	30	a	a	DT
cord-344093-3bniy5b5	255	31	threshold	threshold	NN
cord-344093-3bniy5b5	255	32	to	to	TO
cord-344093-3bniy5b5	255	33	favor	favor	VB
cord-344093-3bniy5b5	255	34	cell	cell	NN
cord-344093-3bniy5b5	255	35	death	death	NN
cord-344093-3bniy5b5	255	36	induction	induction	NN
cord-344093-3bniy5b5	255	37	.	.	.
cord-344093-3bniy5b5	256	1	Accordingly	accordingly	RB
cord-344093-3bniy5b5	256	2	,	,	,
cord-344093-3bniy5b5	256	3	as	as	IN
cord-344093-3bniy5b5	256	4	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	256	5	signaling	signaling	NN
cord-344093-3bniy5b5	256	6	is	be	VBZ
cord-344093-3bniy5b5	256	7	not	not	RB
cord-344093-3bniy5b5	256	8	restricted	restrict	VBN
cord-344093-3bniy5b5	256	9	to	to	IN
cord-344093-3bniy5b5	256	10	infected	infected	JJ
cord-344093-3bniy5b5	256	11	cells	cell	NNS
cord-344093-3bniy5b5	256	12	,	,	,
cord-344093-3bniy5b5	256	13	excessive	excessive	JJ
cord-344093-3bniy5b5	256	14	cell	cell	NN
cord-344093-3bniy5b5	256	15	death	death	NN
cord-344093-3bniy5b5	256	16	activation	activation	NN
cord-344093-3bniy5b5	256	17	might	may	MD
cord-344093-3bniy5b5	256	18	be	be	VB
cord-344093-3bniy5b5	256	19	limited	limit	VBN
cord-344093-3bniy5b5	256	20	by	by	IN
cord-344093-3bniy5b5	256	21	autophagy	autophagy	NN
cord-344093-3bniy5b5	256	22	induction	induction	NN
cord-344093-3bniy5b5	256	23	in	in	IN
cord-344093-3bniy5b5	256	24	non	non	JJ
cord-344093-3bniy5b5	256	25	-	-	JJ
cord-344093-3bniy5b5	256	26	infected	infected	JJ
cord-344093-3bniy5b5	256	27	bystander	bystander	NN
cord-344093-3bniy5b5	256	28	cells	cell	NNS
cord-344093-3bniy5b5	256	29	.	.	.
cord-344093-3bniy5b5	257	1	However	however	RB
cord-344093-3bniy5b5	257	2	,	,	,
cord-344093-3bniy5b5	257	3	autophagy	autophagy	NN
cord-344093-3bniy5b5	257	4	is	be	VBZ
cord-344093-3bniy5b5	257	5	not	not	RB
cord-344093-3bniy5b5	257	6	only	only	RB
cord-344093-3bniy5b5	257	7	related	relate	VBN
cord-344093-3bniy5b5	257	8	to	to	IN
cord-344093-3bniy5b5	257	9	cell	cell	NN
cord-344093-3bniy5b5	257	10	survival	survival	NN
cord-344093-3bniy5b5	257	11	but	but	CC
cord-344093-3bniy5b5	257	12	can	can	MD
cord-344093-3bniy5b5	257	13	also	also	RB
cord-344093-3bniy5b5	257	14	positively	positively	RB
cord-344093-3bniy5b5	257	15	affect	affect	VB
cord-344093-3bniy5b5	257	16	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	257	17	and	and	CC
cord-344093-3bniy5b5	257	18	induce	induce	VB
cord-344093-3bniy5b5	257	19	-	-	:
cord-344093-3bniy5b5	257	20	even	even	RB
cord-344093-3bniy5b5	257	21	if	if	IN
cord-344093-3bniy5b5	257	22	the	the	DT
cord-344093-3bniy5b5	257	23	exact	exact	JJ
cord-344093-3bniy5b5	257	24	mechanisms	mechanism	NNS
cord-344093-3bniy5b5	257	25	are	be	VBP
cord-344093-3bniy5b5	257	26	still	still	RB
cord-344093-3bniy5b5	257	27	under	under	IN
cord-344093-3bniy5b5	257	28	debate	debate	NN
cord-344093-3bniy5b5	257	29	-	-	HYPH
cord-344093-3bniy5b5	257	30	autosis	autosis	NN
cord-344093-3bniy5b5	257	31	,	,	,
cord-344093-3bniy5b5	257	32	the	the	DT
cord-344093-3bniy5b5	257	33	autophagy	autophagy	NN
cord-344093-3bniy5b5	257	34	-	-	HYPH
cord-344093-3bniy5b5	257	35	related	relate	VBN
cord-344093-3bniy5b5	257	36	cell	cell	NN
cord-344093-3bniy5b5	257	37	death	death	NN
cord-344093-3bniy5b5	257	38	,	,	,
cord-344093-3bniy5b5	257	39	another	another	DT
cord-344093-3bniy5b5	257	40	mode	mode	NN
cord-344093-3bniy5b5	257	41	of	of	IN
cord-344093-3bniy5b5	257	42	TRAIL	trail	NN
cord-344093-3bniy5b5	257	43	to	to	TO
cord-344093-3bniy5b5	257	44	trigger	trigger	VB
cord-344093-3bniy5b5	257	45	cell	cell	NN
cord-344093-3bniy5b5	257	46	death	death	NN
cord-344093-3bniy5b5	257	47	(	(	-LRB-
cord-344093-3bniy5b5	257	48	156	156	CD
cord-344093-3bniy5b5	257	49	,	,	,
cord-344093-3bniy5b5	257	50	157	157	CD
cord-344093-3bniy5b5	257	51	)	)	-RRB-
cord-344093-3bniy5b5	257	52	.	.	.
cord-344093-3bniy5b5	258	1	Of	of	IN
cord-344093-3bniy5b5	258	2	note	note	NN
cord-344093-3bniy5b5	258	3	,	,	,
cord-344093-3bniy5b5	258	4	autophagy	autophagy	NN
cord-344093-3bniy5b5	258	5	activation	activation	NN
cord-344093-3bniy5b5	258	6	needs	need	NNS
cord-344093-3bniy5b5	258	7	to	to	TO
cord-344093-3bniy5b5	258	8	be	be	VB
cord-344093-3bniy5b5	258	9	placed	place	VBN
cord-344093-3bniy5b5	258	10	into	into	IN
cord-344093-3bniy5b5	258	11	its	-PRON-	PRP$
cord-344093-3bniy5b5	258	12	virus	virus	NN
cord-344093-3bniy5b5	258	13	-	-	HYPH
cord-344093-3bniy5b5	258	14	specific	specific	JJ
cord-344093-3bniy5b5	258	15	context	context	NN
cord-344093-3bniy5b5	258	16	,	,	,
cord-344093-3bniy5b5	258	17	as	as	IN
cord-344093-3bniy5b5	258	18	some	some	DT
cord-344093-3bniy5b5	258	19	viruses	virus	NNS
cord-344093-3bniy5b5	258	20	,	,	,
cord-344093-3bniy5b5	258	21	including	include	VBG
cord-344093-3bniy5b5	258	22	Dengue	dengue	NN
cord-344093-3bniy5b5	258	23	virus	virus	NN
cord-344093-3bniy5b5	258	24	,	,	,
cord-344093-3bniy5b5	258	25	poliovirus	poliovirus	NN
cord-344093-3bniy5b5	258	26	,	,	,
cord-344093-3bniy5b5	258	27	and	and	CC
cord-344093-3bniy5b5	258	28	Coxsackie	Coxsackie	NNP
cord-344093-3bniy5b5	258	29	B	B	NNP
cord-344093-3bniy5b5	258	30	virus	virus	NN
cord-344093-3bniy5b5	258	31	(	(	-LRB-
cord-344093-3bniy5b5	258	32	158	158	CD
cord-344093-3bniy5b5	258	33	)	)	-RRB-
cord-344093-3bniy5b5	258	34	,	,	,
cord-344093-3bniy5b5	258	35	can	can	MD
cord-344093-3bniy5b5	258	36	exploit	exploit	VB
cord-344093-3bniy5b5	258	37	autophagic	autophagic	JJ
cord-344093-3bniy5b5	258	38	pathways	pathway	NNS
cord-344093-3bniy5b5	258	39	for	for	IN
cord-344093-3bniy5b5	258	40	their	-PRON-	PRP$
cord-344093-3bniy5b5	258	41	own	own	JJ
cord-344093-3bniy5b5	258	42	replication	replication	NN
cord-344093-3bniy5b5	258	43	and	and	CC
cord-344093-3bniy5b5	258	44	thus	thus	RB
cord-344093-3bniy5b5	258	45	promote	promote	VB
cord-344093-3bniy5b5	258	46	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	258	47	and	and	CC
cord-344093-3bniy5b5	258	48	tissue	tissue	NN
cord-344093-3bniy5b5	258	49	injury	injury	NN
cord-344093-3bniy5b5	258	50	.	.	.
cord-344093-3bniy5b5	259	1	As	as	IN
cord-344093-3bniy5b5	259	2	discussed	discuss	VBN
cord-344093-3bniy5b5	259	3	above	above	RB
cord-344093-3bniy5b5	259	4	,	,	,
cord-344093-3bniy5b5	259	5	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	259	6	is	be	VBZ
cord-344093-3bniy5b5	259	7	a	a	DT
cord-344093-3bniy5b5	259	8	potent	potent	JJ
cord-344093-3bniy5b5	259	9	activator	activator	NN
cord-344093-3bniy5b5	259	10	of	of	IN
cord-344093-3bniy5b5	259	11	cell	cell	NN
cord-344093-3bniy5b5	259	12	death	death	NN
cord-344093-3bniy5b5	259	13	.	.	.
cord-344093-3bniy5b5	260	1	However	however	RB
cord-344093-3bniy5b5	260	2	,	,	,
cord-344093-3bniy5b5	260	3	its	-PRON-	PRP$
cord-344093-3bniy5b5	260	4	signaling	signal	VBG
cord-344093-3bniy5b5	260	5	outcomes	outcome	NNS
cord-344093-3bniy5b5	260	6	can	can	MD
cord-344093-3bniy5b5	260	7	differ	differ	VB
cord-344093-3bniy5b5	260	8	largely	largely	RB
cord-344093-3bniy5b5	260	9	depending	depend	VBG
cord-344093-3bniy5b5	260	10	on	on	IN
cord-344093-3bniy5b5	260	11	its	-PRON-	PRP$
cord-344093-3bniy5b5	260	12	delivered	deliver	VBN
cord-344093-3bniy5b5	260	13	form	form	NN
cord-344093-3bniy5b5	260	14	(	(	-LRB-
cord-344093-3bniy5b5	260	15	e.g.	e.g.	RB
cord-344093-3bniy5b5	260	16	,	,	,
cord-344093-3bniy5b5	260	17	membrane	membrane	NN
cord-344093-3bniy5b5	260	18	-	-	HYPH
cord-344093-3bniy5b5	260	19	bound	bind	VBN
cord-344093-3bniy5b5	260	20	versus	versus	IN
cord-344093-3bniy5b5	260	21	soluble	soluble	JJ
cord-344093-3bniy5b5	260	22	)	)	-RRB-
cord-344093-3bniy5b5	260	23	,	,	,
cord-344093-3bniy5b5	260	24	the	the	DT
cord-344093-3bniy5b5	260	25	availability	availability	NN
cord-344093-3bniy5b5	260	26	of	of	IN
cord-344093-3bniy5b5	260	27	DRs	dr	NNS
cord-344093-3bniy5b5	260	28	on	on	IN
cord-344093-3bniy5b5	260	29	the	the	DT
cord-344093-3bniy5b5	260	30	target	target	NN
cord-344093-3bniy5b5	260	31	cell	cell	NN
cord-344093-3bniy5b5	260	32	membrane	membrane	NN
cord-344093-3bniy5b5	260	33	,	,	,
cord-344093-3bniy5b5	260	34	alternate	alternate	JJ
cord-344093-3bniy5b5	260	35	intracellular	intracellular	JJ
cord-344093-3bniy5b5	260	36	pathways	pathway	NNS
cord-344093-3bniy5b5	260	37	that	that	WDT
cord-344093-3bniy5b5	260	38	might	may	MD
cord-344093-3bniy5b5	260	39	be	be	VB
cord-344093-3bniy5b5	260	40	activated	activate	VBN
cord-344093-3bniy5b5	260	41	and	and	CC
cord-344093-3bniy5b5	260	42	finally	finally	RB
cord-344093-3bniy5b5	260	43	the	the	DT
cord-344093-3bniy5b5	260	44	pathogen	pathogen	NN
cord-344093-3bniy5b5	260	45	itself	-PRON-	PRP
cord-344093-3bniy5b5	260	46	,	,	,
cord-344093-3bniy5b5	260	47	as	as	IN
cord-344093-3bniy5b5	260	48	it	-PRON-	PRP
cord-344093-3bniy5b5	260	49	might	may	MD
cord-344093-3bniy5b5	260	50	exploit	exploit	VB
cord-344093-3bniy5b5	260	51	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	260	52	-	-	HYPH
cord-344093-3bniy5b5	260	53	induced	induce	VBN
cord-344093-3bniy5b5	260	54	pathways	pathway	NNS
cord-344093-3bniy5b5	260	55	for	for	IN
cord-344093-3bniy5b5	260	56	its	-PRON-	PRP$
cord-344093-3bniy5b5	260	57	own	own	JJ
cord-344093-3bniy5b5	260	58	survival	survival	NN
cord-344093-3bniy5b5	260	59	and	and	CC
cord-344093-3bniy5b5	260	60	replication	replication	NN
cord-344093-3bniy5b5	260	61	.	.	.
cord-344093-3bniy5b5	261	1	In	in	IN
cord-344093-3bniy5b5	261	2	acute	acute	JJ
cord-344093-3bniy5b5	261	3	respiratory	respiratory	JJ
cord-344093-3bniy5b5	261	4	infection	infection	NN
cord-344093-3bniy5b5	261	5	,	,	,
cord-344093-3bniy5b5	261	6	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	261	7	signaling	signaling	NN
cord-344093-3bniy5b5	261	8	is	be	VBZ
cord-344093-3bniy5b5	261	9	often	often	RB
cord-344093-3bniy5b5	261	10	part	part	NN
cord-344093-3bniy5b5	261	11	of	of	IN
cord-344093-3bniy5b5	261	12	an	an	DT
cord-344093-3bniy5b5	261	13	IFN	IFN	NNP
cord-344093-3bniy5b5	261	14	-	-	HYPH
cord-344093-3bniy5b5	261	15	driven	drive	VBN
cord-344093-3bniy5b5	261	16	overshooting	overshoot	VBG
cord-344093-3bniy5b5	261	17	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	261	18	reaction	reaction	NN
cord-344093-3bniy5b5	261	19	that	that	WDT
cord-344093-3bniy5b5	261	20	promotes	promote	VBZ
cord-344093-3bniy5b5	261	21	unspecific	unspecific	JJ
cord-344093-3bniy5b5	261	22	tissue	tissue	NN
cord-344093-3bniy5b5	261	23	injury	injury	NN
cord-344093-3bniy5b5	261	24	and	and	CC
cord-344093-3bniy5b5	261	25	thus	thus	RB
cord-344093-3bniy5b5	261	26	disease	disease	NN
cord-344093-3bniy5b5	261	27	severity	severity	NN
cord-344093-3bniy5b5	261	28	by	by	IN
cord-344093-3bniy5b5	261	29	increasing	increase	VBG
cord-344093-3bniy5b5	261	30	functional	functional	JJ
cord-344093-3bniy5b5	261	31	and	and	CC
cord-344093-3bniy5b5	261	32	structural	structural	JJ
cord-344093-3bniy5b5	261	33	changes	change	NNS
cord-344093-3bniy5b5	261	34	in	in	IN
cord-344093-3bniy5b5	261	35	infected	infected	JJ
cord-344093-3bniy5b5	261	36	but	but	CC
cord-344093-3bniy5b5	261	37	also	also	RB
cord-344093-3bniy5b5	261	38	non	non	JJ
cord-344093-3bniy5b5	261	39	-	-	JJ
cord-344093-3bniy5b5	261	40	infected	infected	JJ
cord-344093-3bniy5b5	261	41	cells	cell	NNS
cord-344093-3bniy5b5	261	42	,	,	,
cord-344093-3bniy5b5	261	43	as	as	IN
cord-344093-3bniy5b5	261	44	will	will	MD
cord-344093-3bniy5b5	261	45	be	be	VB
cord-344093-3bniy5b5	261	46	outlined	outline	VBN
cord-344093-3bniy5b5	261	47	below	below	RB
cord-344093-3bniy5b5	261	48	.	.	.
cord-344093-3bniy5b5	262	1	The	the	DT
cord-344093-3bniy5b5	262	2	release	release	NN
cord-344093-3bniy5b5	262	3	and	and	CC
cord-344093-3bniy5b5	262	4	effects	effect	NNS
cord-344093-3bniy5b5	262	5	of	of	IN
cord-344093-3bniy5b5	262	6	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	262	7	have	have	VBP
cord-344093-3bniy5b5	262	8	been	be	VBN
cord-344093-3bniy5b5	262	9	especially	especially	RB
cord-344093-3bniy5b5	262	10	well	well	RB
cord-344093-3bniy5b5	262	11	studied	study	VBN
cord-344093-3bniy5b5	262	12	in	in	IN
cord-344093-3bniy5b5	262	13	IAV	IAV	NNP
cord-344093-3bniy5b5	262	14	infection	infection	NN
cord-344093-3bniy5b5	262	15	in	in	IN
cord-344093-3bniy5b5	262	16	the	the	DT
cord-344093-3bniy5b5	262	17	last	last	JJ
cord-344093-3bniy5b5	262	18	decade	decade	NN
cord-344093-3bniy5b5	262	19	.	.	.
cord-344093-3bniy5b5	263	1	Earlier	early	JJR
cord-344093-3bniy5b5	263	2	studies	study	NNS
cord-344093-3bniy5b5	263	3	reported	report	VBD
cord-344093-3bniy5b5	263	4	that	that	IN
cord-344093-3bniy5b5	263	5	within	within	IN
cord-344093-3bniy5b5	263	6	3	3	CD
cord-344093-3bniy5b5	263	7	days	day	NNS
cord-344093-3bniy5b5	263	8	after	after	IN
cord-344093-3bniy5b5	263	9	infection	infection	NN
cord-344093-3bniy5b5	263	10	,	,	,
cord-344093-3bniy5b5	263	11	bronchial	bronchial	JJ
cord-344093-3bniy5b5	263	12	,	,	,
cord-344093-3bniy5b5	263	13	bronchiolar	bronchiolar	JJ
cord-344093-3bniy5b5	263	14	,	,	,
cord-344093-3bniy5b5	263	15	and	and	CC
cord-344093-3bniy5b5	263	16	alveolar	alveolar	JJ
cord-344093-3bniy5b5	263	17	epithelial	epithelial	JJ
cord-344093-3bniy5b5	263	18	cells	cell	NNS
cord-344093-3bniy5b5	263	19	undergo	undergo	VBP
cord-344093-3bniy5b5	263	20	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	263	21	(	(	-LRB-
cord-344093-3bniy5b5	263	22	159	159	CD
cord-344093-3bniy5b5	263	23	)	)	-RRB-
cord-344093-3bniy5b5	263	24	.	.	.
cord-344093-3bniy5b5	264	1	This	this	DT
cord-344093-3bniy5b5	264	2	early	early	JJ
cord-344093-3bniy5b5	264	3	induction	induction	NN
cord-344093-3bniy5b5	264	4	of	of	IN
cord-344093-3bniy5b5	264	5	cell	cell	NN
cord-344093-3bniy5b5	264	6	death	death	NN
cord-344093-3bniy5b5	264	7	is	be	VBZ
cord-344093-3bniy5b5	264	8	mainly	mainly	RB
cord-344093-3bniy5b5	264	9	attributed	attribute	VBN
cord-344093-3bniy5b5	264	10	to	to	IN
cord-344093-3bniy5b5	264	11	direct	direct	JJ
cord-344093-3bniy5b5	264	12	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	264	13	induction	induction	NN
cord-344093-3bniy5b5	264	14	by	by	IN
cord-344093-3bniy5b5	264	15	the	the	DT
cord-344093-3bniy5b5	264	16	virus	virus	NN
cord-344093-3bniy5b5	264	17	itself	-PRON-	PRP
cord-344093-3bniy5b5	264	18	,	,	,
cord-344093-3bniy5b5	264	19	as	as	IN
cord-344093-3bniy5b5	264	20	IAV	IAV	NNP
cord-344093-3bniy5b5	264	21	actively	actively	RB
cord-344093-3bniy5b5	264	22	promotes	promote	VBZ
cord-344093-3bniy5b5	264	23	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	264	24	for	for	IN
cord-344093-3bniy5b5	264	25	efficient	efficient	JJ
cord-344093-3bniy5b5	264	26	viral	viral	JJ
cord-344093-3bniy5b5	264	27	replication	replication	NN
cord-344093-3bniy5b5	264	28	(	(	-LRB-
cord-344093-3bniy5b5	264	29	160	160	CD
cord-344093-3bniy5b5	264	30	)	)	-RRB-
cord-344093-3bniy5b5	264	31	.	.	.
cord-344093-3bniy5b5	265	1	Herein	herein	RB
cord-344093-3bniy5b5	265	2	,	,	,
cord-344093-3bniy5b5	265	3	the	the	DT
cord-344093-3bniy5b5	265	4	viral	viral	JJ
cord-344093-3bniy5b5	265	5	NS1	ns1	NN
cord-344093-3bniy5b5	265	6	and	and	CC
cord-344093-3bniy5b5	265	7	PB	PB	NNP
cord-344093-3bniy5b5	265	8	-	-	HYPH
cord-344093-3bniy5b5	265	9	F2	F2	NNP
cord-344093-3bniy5b5	265	10	proteins	protein	NNS
cord-344093-3bniy5b5	265	11	not	not	RB
cord-344093-3bniy5b5	265	12	only	only	RB
cord-344093-3bniy5b5	265	13	play	play	VBP
cord-344093-3bniy5b5	265	14	a	a	DT
cord-344093-3bniy5b5	265	15	crucial	crucial	JJ
cord-344093-3bniy5b5	265	16	role	role	NN
cord-344093-3bniy5b5	265	17	(	(	-LRB-
cord-344093-3bniy5b5	265	18	161	161	CD
cord-344093-3bniy5b5	265	19	,	,	,
cord-344093-3bniy5b5	265	20	162	162	CD
cord-344093-3bniy5b5	265	21	)	)	-RRB-
cord-344093-3bniy5b5	265	22	but	but	CC
cord-344093-3bniy5b5	265	23	also	also	RB
cord-344093-3bniy5b5	265	24	the	the	DT
cord-344093-3bniy5b5	265	25	viral	viral	JJ
cord-344093-3bniy5b5	265	26	M2	M2	NNP
cord-344093-3bniy5b5	265	27	protein	protein	NN
cord-344093-3bniy5b5	265	28	has	have	VBZ
cord-344093-3bniy5b5	265	29	been	be	VBN
cord-344093-3bniy5b5	265	30	implicated	implicate	VBN
cord-344093-3bniy5b5	265	31	in	in	IN
cord-344093-3bniy5b5	265	32	this	this	DT
cord-344093-3bniy5b5	265	33	process	process	NN
cord-344093-3bniy5b5	265	34	as	as	IN
cord-344093-3bniy5b5	265	35	it	-PRON-	PRP
cord-344093-3bniy5b5	265	36	inhibits	inhibit	VBZ
cord-344093-3bniy5b5	265	37	autophagy	autophagy	NN
cord-344093-3bniy5b5	265	38	in	in	IN
cord-344093-3bniy5b5	265	39	infected	infected	JJ
cord-344093-3bniy5b5	265	40	cells	cell	NNS
cord-344093-3bniy5b5	265	41	(	(	-LRB-
cord-344093-3bniy5b5	265	42	163	163	CD
cord-344093-3bniy5b5	265	43	)	)	-RRB-
cord-344093-3bniy5b5	265	44	.	.	.
cord-344093-3bniy5b5	266	1	In	in	IN
cord-344093-3bniy5b5	266	2	addition	addition	NN
cord-344093-3bniy5b5	266	3	,	,	,
cord-344093-3bniy5b5	266	4	our	-PRON-	PRP$
cord-344093-3bniy5b5	266	5	own	own	JJ
cord-344093-3bniy5b5	266	6	data	datum	NNS
cord-344093-3bniy5b5	266	7	revealed	reveal	VBD
cord-344093-3bniy5b5	266	8	that	that	IN
cord-344093-3bniy5b5	266	9	later	later	RB
cord-344093-3bniy5b5	266	10	in	in	IN
cord-344093-3bniy5b5	266	11	IAV	IAV	NNP
cord-344093-3bniy5b5	266	12	in	in	IN
cord-344093-3bniy5b5	266	13	vivo	vivo	NN
cord-344093-3bniy5b5	266	14	infection	infection	NN
cord-344093-3bniy5b5	266	15	,	,	,
cord-344093-3bniy5b5	266	16	the	the	DT
cord-344093-3bniy5b5	266	17	recruitment	recruitment	NN
cord-344093-3bniy5b5	266	18	of	of	IN
cord-344093-3bniy5b5	266	19	bone	bone	NN
cord-344093-3bniy5b5	266	20	marrowderived	marrowderive	VBN
cord-344093-3bniy5b5	266	21	macrophages	macrophage	NNS
cord-344093-3bniy5b5	266	22	via	via	IN
cord-344093-3bniy5b5	266	23	the	the	DT
cord-344093-3bniy5b5	266	24	CC	CC	NNP
cord-344093-3bniy5b5	266	25	chemokine	chemokine	NN
cord-344093-3bniy5b5	266	26	receptor	receptor	NN
cord-344093-3bniy5b5	266	27	type	type	NN
cord-344093-3bniy5b5	266	28	2	2	CD
cord-344093-3bniy5b5	266	29	(	(	-LRB-
cord-344093-3bniy5b5	266	30	CCR2)-CC	ccr2)-cc	JJ
cord-344093-3bniy5b5	266	31	-	-	HYPH
cord-344093-3bniy5b5	266	32	chemokine	chemokine	NN
cord-344093-3bniy5b5	266	33	ligand	ligand	NN
cord-344093-3bniy5b5	266	34	2	2	CD
cord-344093-3bniy5b5	267	1	(	(	-LRB-
cord-344093-3bniy5b5	267	2	CCL2	CCL2	NNP
cord-344093-3bniy5b5	267	3	)	)	-RRB-
cord-344093-3bniy5b5	267	4	axis	axis	NN
cord-344093-3bniy5b5	267	5	significantly	significantly	RB
cord-344093-3bniy5b5	267	6	contributes	contribute	VBZ
cord-344093-3bniy5b5	267	7	to	to	IN
cord-344093-3bniy5b5	267	8	alveolar	alveolar	JJ
cord-344093-3bniy5b5	267	9	cell	cell	NN
cord-344093-3bniy5b5	267	10	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	267	11	and	and	CC
cord-344093-3bniy5b5	267	12	structural	structural	JJ
cord-344093-3bniy5b5	267	13	damage	damage	NN
cord-344093-3bniy5b5	267	14	of	of	IN
cord-344093-3bniy5b5	267	15	the	the	DT
cord-344093-3bniy5b5	267	16	alveolar	alveolar	JJ
cord-344093-3bniy5b5	267	17	epithelium	epithelium	NN
cord-344093-3bniy5b5	267	18	(	(	-LRB-
cord-344093-3bniy5b5	267	19	5	5	CD
cord-344093-3bniy5b5	267	20	)	)	-RRB-
cord-344093-3bniy5b5	267	21	.	.	.
cord-344093-3bniy5b5	268	1	Studies	study	NNS
cord-344093-3bniy5b5	268	2	by	by	IN
cord-344093-3bniy5b5	268	3	Wurzer	Wurzer	NNP
cord-344093-3bniy5b5	268	4	et	et	NNP
cord-344093-3bniy5b5	268	5	al	al	NNP
cord-344093-3bniy5b5	268	6	.	.	.
cord-344093-3bniy5b5	269	1	(	(	-LRB-
cord-344093-3bniy5b5	269	2	164	164	CD
cord-344093-3bniy5b5	269	3	)	)	-RRB-
cord-344093-3bniy5b5	269	4	had	have	VBD
cord-344093-3bniy5b5	269	5	previously	previously	RB
cord-344093-3bniy5b5	269	6	demonstrated	demonstrate	VBN
cord-344093-3bniy5b5	269	7	that	that	IN
cord-344093-3bniy5b5	269	8	IAV	IAV	NNP
cord-344093-3bniy5b5	269	9	promotes	promote	VBZ
cord-344093-3bniy5b5	269	10	the	the	DT
cord-344093-3bniy5b5	269	11	production	production	NN
cord-344093-3bniy5b5	269	12	of	of	IN
cord-344093-3bniy5b5	269	13	proapoptotic	proapoptotic	JJ
cord-344093-3bniy5b5	269	14	factors	factor	NNS
cord-344093-3bniy5b5	269	15	in	in	IN
cord-344093-3bniy5b5	269	16	an	an	DT
cord-344093-3bniy5b5	269	17	auto	auto	NN
cord-344093-3bniy5b5	269	18	-	-	HYPH
cord-344093-3bniy5b5	269	19	and	and	CC
cord-344093-3bniy5b5	269	20	paracrine	paracrine	JJ
cord-344093-3bniy5b5	269	21	fashion	fashion	NN
cord-344093-3bniy5b5	269	22	via	via	IN
cord-344093-3bniy5b5	269	23	NFκB	NFκB	NNP
cord-344093-3bniy5b5	269	24	transcriptional	transcriptional	JJ
cord-344093-3bniy5b5	269	25	activation	activation	NN
cord-344093-3bniy5b5	269	26	by	by	IN
cord-344093-3bniy5b5	269	27	IAV	IAV	NNP
cord-344093-3bniy5b5	269	28	(	(	-LRB-
cord-344093-3bniy5b5	269	29	164	164	CD
cord-344093-3bniy5b5	269	30	)	)	-RRB-
cord-344093-3bniy5b5	269	31	.	.	.
cord-344093-3bniy5b5	270	1	Subsequently	subsequently	RB
cord-344093-3bniy5b5	270	2	,	,	,
cord-344093-3bniy5b5	270	3	Brincks	Brincks	NNP
cord-344093-3bniy5b5	270	4	et	et	NNP
cord-344093-3bniy5b5	270	5	al	al	NNP
cord-344093-3bniy5b5	270	6	.	.	.
cord-344093-3bniy5b5	271	1	(	(	-LRB-
cord-344093-3bniy5b5	271	2	6	6	LS
cord-344093-3bniy5b5	271	3	)	)	-RRB-
cord-344093-3bniy5b5	271	4	elucidated	elucidate	VBD
cord-344093-3bniy5b5	271	5	that	that	IN
cord-344093-3bniy5b5	271	6	human	human	JJ
cord-344093-3bniy5b5	271	7	peripheral	peripheral	JJ
cord-344093-3bniy5b5	271	8	blood	blood	NN
cord-344093-3bniy5b5	271	9	mononuclear	mononuclear	JJ
cord-344093-3bniy5b5	271	10	cell	cell	NN
cord-344093-3bniy5b5	271	11	treated	treat	VBN
cord-344093-3bniy5b5	271	12	with	with	IN
cord-344093-3bniy5b5	271	13	IAV	IAV	NNP
cord-344093-3bniy5b5	271	14	released	release	VBD
cord-344093-3bniy5b5	271	15	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	271	16	and	and	CC
cord-344093-3bniy5b5	271	17	that	that	IN
cord-344093-3bniy5b5	271	18	increased	increase	VBD
cord-344093-3bniy5b5	271	19	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	271	20	levels	level	NNS
cord-344093-3bniy5b5	271	21	correlated	correlate	VBN
cord-344093-3bniy5b5	271	22	with	with	IN
cord-344093-3bniy5b5	271	23	type	type	NN
cord-344093-3bniy5b5	271	24	I	-PRON-	PRP
cord-344093-3bniy5b5	271	25	as	as	RB
cord-344093-3bniy5b5	271	26	well	well	RB
cord-344093-3bniy5b5	271	27	as	as	IN
cord-344093-3bniy5b5	271	28	II	II	NNP
cord-344093-3bniy5b5	271	29	IFN	IFN	NNP
cord-344093-3bniy5b5	271	30	induction	induction	NN
cord-344093-3bniy5b5	271	31	.	.	.
cord-344093-3bniy5b5	272	1	Additionally	additionally	RB
cord-344093-3bniy5b5	272	2	,	,	,
cord-344093-3bniy5b5	272	3	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	272	4	sensitivity	sensitivity	NN
cord-344093-3bniy5b5	272	5	was	be	VBD
cord-344093-3bniy5b5	272	6	increased	increase	VBN
cord-344093-3bniy5b5	272	7	in	in	IN
cord-344093-3bniy5b5	272	8	influenza	influenza	NN
cord-344093-3bniy5b5	272	9	virusinfected	virusinfecte	VBN
cord-344093-3bniy5b5	272	10	cells	cell	NNS
cord-344093-3bniy5b5	272	11	.	.	.
cord-344093-3bniy5b5	273	1	In	in	IN
cord-344093-3bniy5b5	273	2	line	line	NN
cord-344093-3bniy5b5	273	3	,	,	,
cord-344093-3bniy5b5	273	4	our	-PRON-	PRP$
cord-344093-3bniy5b5	273	5	investigations	investigation	NNS
cord-344093-3bniy5b5	273	6	could	could	MD
cord-344093-3bniy5b5	273	7	elucidate	elucidate	VB
cord-344093-3bniy5b5	273	8	that	that	IN
cord-344093-3bniy5b5	273	9	IAV	IAV	NNP
cord-344093-3bniy5b5	273	10	triggers	trigger	VBZ
cord-344093-3bniy5b5	273	11	a	a	DT
cord-344093-3bniy5b5	273	12	PKR	PKR	NNP
cord-344093-3bniy5b5	273	13	-	-	HYPH
cord-344093-3bniy5b5	273	14	dependent	dependent	JJ
cord-344093-3bniy5b5	273	15	translocation	translocation	NN
cord-344093-3bniy5b5	273	16	of	of	IN
cord-344093-3bniy5b5	273	17	NFκB	NFκB	NNP
cord-344093-3bniy5b5	273	18	that	that	WDT
cord-344093-3bniy5b5	273	19	results	result	VBZ
cord-344093-3bniy5b5	273	20	the	the	DT
cord-344093-3bniy5b5	273	21	production	production	NN
cord-344093-3bniy5b5	273	22	of	of	IN
cord-344093-3bniy5b5	273	23	type	type	NN
cord-344093-3bniy5b5	273	24	I	-PRON-	PRP
cord-344093-3bniy5b5	273	25	IFNs	ifns	VBP
cord-344093-3bniy5b5	273	26	.	.	.
cord-344093-3bniy5b5	274	1	These	these	DT
cord-344093-3bniy5b5	274	2	in	in	IN
cord-344093-3bniy5b5	274	3	turn	turn	NN
cord-344093-3bniy5b5	274	4	induce	induce	VB
cord-344093-3bniy5b5	274	5	,	,	,
cord-344093-3bniy5b5	274	6	via	via	IN
cord-344093-3bniy5b5	274	7	ligation	ligation	NN
cord-344093-3bniy5b5	274	8	to	to	IN
cord-344093-3bniy5b5	274	9	the	the	DT
cord-344093-3bniy5b5	274	10	IFNAR	IFNAR	NNP
cord-344093-3bniy5b5	274	11	receptor	receptor	NN
cord-344093-3bniy5b5	274	12	complex	complex	NN
cord-344093-3bniy5b5	274	13	,	,	,
cord-344093-3bniy5b5	274	14	expression	expression	NN
cord-344093-3bniy5b5	274	15	and	and	CC
cord-344093-3bniy5b5	274	16	shedding	shedding	NN
cord-344093-3bniy5b5	274	17	of	of	IN
cord-344093-3bniy5b5	274	18	TRAIL	trail	NN
cord-344093-3bniy5b5	274	19	by	by	IN
cord-344093-3bniy5b5	274	20	bone	bone	NN
cord-344093-3bniy5b5	274	21	marrow	marrow	NN
cord-344093-3bniy5b5	274	22	-	-	HYPH
cord-344093-3bniy5b5	274	23	derived	derive	VBN
cord-344093-3bniy5b5	274	24	macrophages	macrophage	NNS
cord-344093-3bniy5b5	274	25	(	(	-LRB-
cord-344093-3bniy5b5	274	26	10	10	CD
cord-344093-3bniy5b5	274	27	)	)	-RRB-
cord-344093-3bniy5b5	274	28	.	.	.
cord-344093-3bniy5b5	275	1	In	in	IN
cord-344093-3bniy5b5	275	2	addition	addition	NN
cord-344093-3bniy5b5	275	3	,	,	,
cord-344093-3bniy5b5	275	4	Davidson	Davidson	NNP
cord-344093-3bniy5b5	275	5	et	et	NNP
cord-344093-3bniy5b5	275	6	al	al	NNP
cord-344093-3bniy5b5	275	7	.	.	.
cord-344093-3bniy5b5	276	1	(	(	-LRB-
cord-344093-3bniy5b5	276	2	74	74	CD
cord-344093-3bniy5b5	276	3	)	)	-RRB-
cord-344093-3bniy5b5	276	4	demonstrated	demonstrate	VBD
cord-344093-3bniy5b5	276	5	that	that	DT
cord-344093-3bniy5b5	276	6	type	type	NN
cord-344093-3bniy5b5	277	1	I	-PRON-	PRP
cord-344093-3bniy5b5	277	2	IFN	IFN	NNP
cord-344093-3bniy5b5	277	3	application	application	NN
cord-344093-3bniy5b5	277	4	to	to	IN
cord-344093-3bniy5b5	277	5	IAVinfected	iavinfected	JJ
cord-344093-3bniy5b5	277	6	mice	mouse	NNS
cord-344093-3bniy5b5	277	7	increased	increase	VBD
cord-344093-3bniy5b5	277	8	morbidity	morbidity	NN
cord-344093-3bniy5b5	277	9	and	and	CC
cord-344093-3bniy5b5	277	10	lung	lung	NN
cord-344093-3bniy5b5	277	11	injury	injury	NN
cord-344093-3bniy5b5	277	12	,	,	,
cord-344093-3bniy5b5	277	13	which	which	WDT
cord-344093-3bniy5b5	277	14	could	could	MD
cord-344093-3bniy5b5	277	15	be	be	VB
cord-344093-3bniy5b5	277	16	attributed	attribute	VBN
cord-344093-3bniy5b5	277	17	to	to	IN
cord-344093-3bniy5b5	277	18	both	both	CC
cord-344093-3bniy5b5	277	19	DR5	DR5	NNP
cord-344093-3bniy5b5	277	20	and	and	CC
cord-344093-3bniy5b5	277	21	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	277	22	upregulation	upregulation	NN
cord-344093-3bniy5b5	277	23	inducing	induce	VBG
cord-344093-3bniy5b5	277	24	epithelial	epithelial	JJ
cord-344093-3bniy5b5	277	25	cell	cell	NN
cord-344093-3bniy5b5	277	26	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	277	27	.	.	.
cord-344093-3bniy5b5	278	1	Importantly	importantly	RB
cord-344093-3bniy5b5	278	2	,	,	,
cord-344093-3bniy5b5	278	3	Högner	Högner	NNP
cord-344093-3bniy5b5	278	4	et	et	NNP
cord-344093-3bniy5b5	278	5	al	al	NNP
cord-344093-3bniy5b5	278	6	.	.	.
cord-344093-3bniy5b5	279	1	also	also	RB
cord-344093-3bniy5b5	279	2	reported	report	VBD
cord-344093-3bniy5b5	279	3	that	that	IN
cord-344093-3bniy5b5	279	4	the	the	DT
cord-344093-3bniy5b5	279	5	IAV	IAV	NNP
cord-344093-3bniy5b5	279	6	strain	strain	NN
cord-344093-3bniy5b5	279	7	used	use	VBN
cord-344093-3bniy5b5	279	8	in	in	IN
cord-344093-3bniy5b5	279	9	these	these	DT
cord-344093-3bniy5b5	279	10	studies	study	NNS
cord-344093-3bniy5b5	279	11	,	,	,
cord-344093-3bniy5b5	279	12	A	A	NNP
cord-344093-3bniy5b5	279	13	/	/	SYM
cord-344093-3bniy5b5	279	14	PR8	PR8	NNP
cord-344093-3bniy5b5	279	15	(	(	-LRB-
cord-344093-3bniy5b5	279	16	H1N1	H1N1	NNP
cord-344093-3bniy5b5	279	17	)	)	-RRB-
cord-344093-3bniy5b5	279	18	,	,	,
cord-344093-3bniy5b5	279	19	which	which	WDT
cord-344093-3bniy5b5	279	20	is	be	VBZ
cord-344093-3bniy5b5	279	21	highly	highly	RB
cord-344093-3bniy5b5	279	22	pathogenic	pathogenic	JJ
cord-344093-3bniy5b5	279	23	for	for	IN
cord-344093-3bniy5b5	279	24	mice	mouse	NNS
cord-344093-3bniy5b5	279	25	,	,	,
cord-344093-3bniy5b5	279	26	induced	induce	VBD
cord-344093-3bniy5b5	279	27	an	an	DT
cord-344093-3bniy5b5	279	28	approximately	approximately	RB
cord-344093-3bniy5b5	279	29	800-fold	800-fold	CD
cord-344093-3bniy5b5	279	30	induction	induction	NN
cord-344093-3bniy5b5	279	31	in	in	IN
cord-344093-3bniy5b5	279	32	macrophage	macrophage	NN
cord-344093-3bniy5b5	279	33	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	279	34	expression	expression	NN
cord-344093-3bniy5b5	279	35	,	,	,
cord-344093-3bniy5b5	279	36	whereas	whereas	IN
cord-344093-3bniy5b5	279	37	the	the	DT
cord-344093-3bniy5b5	279	38	lower	lower	RBR
cord-344093-3bniy5b5	279	39	pathogenic	pathogenic	JJ
cord-344093-3bniy5b5	279	40	virus	virus	NN
cord-344093-3bniy5b5	279	41	A	a	NN
cord-344093-3bniy5b5	279	42	/	/	SYM
cord-344093-3bniy5b5	279	43	X-31	X-31	NNP
cord-344093-3bniy5b5	279	44	(	(	-LRB-
cord-344093-3bniy5b5	279	45	H3N2	H3N2	NNP
cord-344093-3bniy5b5	279	46	)	)	-RRB-
cord-344093-3bniy5b5	279	47	only	only	RB
cord-344093-3bniy5b5	279	48	stimulated	stimulate	VBD
cord-344093-3bniy5b5	279	49	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	279	50	by	by	IN
cord-344093-3bniy5b5	279	51	a	a	DT
cord-344093-3bniy5b5	279	52	factor	factor	NN
cord-344093-3bniy5b5	279	53	of	of	IN
cord-344093-3bniy5b5	279	54	eight	eight	CD
cord-344093-3bniy5b5	279	55	.	.	.
cord-344093-3bniy5b5	280	1	Of	of	IN
cord-344093-3bniy5b5	280	2	note	note	NN
cord-344093-3bniy5b5	280	3	,	,	,
cord-344093-3bniy5b5	280	4	the	the	DT
cord-344093-3bniy5b5	280	5	relation	relation	NN
cord-344093-3bniy5b5	280	6	between	between	IN
cord-344093-3bniy5b5	280	7	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	280	8	induction	induction	NN
cord-344093-3bniy5b5	280	9	and	and	CC
cord-344093-3bniy5b5	280	10	IAV	IAV	NNP
cord-344093-3bniy5b5	280	11	strain	strain	NN
cord-344093-3bniy5b5	280	12	-	-	HYPH
cord-344093-3bniy5b5	280	13	specific	specific	JJ
cord-344093-3bniy5b5	280	14	pathogenicity	pathogenicity	NN
cord-344093-3bniy5b5	280	15	also	also	RB
cord-344093-3bniy5b5	280	16	translates	translate	VBZ
cord-344093-3bniy5b5	280	17	to	to	IN
cord-344093-3bniy5b5	280	18	the	the	DT
cord-344093-3bniy5b5	280	19	highly	highly	RB
cord-344093-3bniy5b5	280	20	pathogenic	pathogenic	JJ
cord-344093-3bniy5b5	280	21	avian	avian	JJ
cord-344093-3bniy5b5	280	22	H5N1	H5N1	NNP
cord-344093-3bniy5b5	280	23	IAV	IAV	NNP
cord-344093-3bniy5b5	280	24	,	,	,
cord-344093-3bniy5b5	280	25	causing	cause	VBG
cord-344093-3bniy5b5	280	26	severe	severe	JJ
cord-344093-3bniy5b5	280	27	pneumonia	pneumonia	NN
cord-344093-3bniy5b5	280	28	in	in	IN
cord-344093-3bniy5b5	280	29	mice	mouse	NNS
cord-344093-3bniy5b5	280	30	as	as	RB
cord-344093-3bniy5b5	280	31	well	well	RB
cord-344093-3bniy5b5	280	32	as	as	IN
cord-344093-3bniy5b5	280	33	in	in	IN
cord-344093-3bniy5b5	280	34	humans	human	NNS
cord-344093-3bniy5b5	280	35	(	(	-LRB-
cord-344093-3bniy5b5	280	36	165	165	CD
cord-344093-3bniy5b5	280	37	,	,	,
cord-344093-3bniy5b5	280	38	166	166	CD
cord-344093-3bniy5b5	280	39	)	)	-RRB-
cord-344093-3bniy5b5	280	40	.	.	.
cord-344093-3bniy5b5	281	1	Moreover	moreover	RB
cord-344093-3bniy5b5	281	2	,	,	,
cord-344093-3bniy5b5	281	3	human	human	JJ
cord-344093-3bniy5b5	281	4	infection	infection	NN
cord-344093-3bniy5b5	281	5	with	with	IN
cord-344093-3bniy5b5	281	6	both	both	CC
cord-344093-3bniy5b5	281	7	the	the	DT
cord-344093-3bniy5b5	281	8	highly	highly	RB
cord-344093-3bniy5b5	281	9	pathogenic	pathogenic	JJ
cord-344093-3bniy5b5	281	10	H5N1	H5N1	NNP
cord-344093-3bniy5b5	281	11	as	as	RB
cord-344093-3bniy5b5	281	12	well	well	RB
cord-344093-3bniy5b5	281	13	as	as	IN
cord-344093-3bniy5b5	281	14	the	the	DT
cord-344093-3bniy5b5	281	15	pandemic	pandemic	NN
cord-344093-3bniy5b5	281	16	1918	1918	CD
cord-344093-3bniy5b5	281	17	H1N1	H1N1	NNP
cord-344093-3bniy5b5	281	18	IAV	IAV	NNP
cord-344093-3bniy5b5	281	19	strains	strain	NNS
cord-344093-3bniy5b5	281	20	are	be	VBP
cord-344093-3bniy5b5	281	21	characterized	characterize	VBN
cord-344093-3bniy5b5	281	22	by	by	IN
cord-344093-3bniy5b5	281	23	a	a	DT
cord-344093-3bniy5b5	281	24	massive	massive	JJ
cord-344093-3bniy5b5	281	25	influx	influx	NN
cord-344093-3bniy5b5	281	26	of	of	IN
cord-344093-3bniy5b5	281	27	mononuclear	mononuclear	JJ
cord-344093-3bniy5b5	281	28	phagocytes	phagocyte	NNS
cord-344093-3bniy5b5	281	29	into	into	IN
cord-344093-3bniy5b5	281	30	the	the	DT
cord-344093-3bniy5b5	281	31	alveoli	alveolus	NNS
cord-344093-3bniy5b5	281	32	,	,	,
cord-344093-3bniy5b5	281	33	which	which	WDT
cord-344093-3bniy5b5	281	34	is	be	VBZ
cord-344093-3bniy5b5	281	35	correlated	correlate	VBN
cord-344093-3bniy5b5	281	36	with	with	IN
cord-344093-3bniy5b5	281	37	extensive	extensive	JJ
cord-344093-3bniy5b5	281	38	alveolar	alveolar	JJ
cord-344093-3bniy5b5	281	39	epithelial	epithelial	JJ
cord-344093-3bniy5b5	281	40	cell	cell	NN
cord-344093-3bniy5b5	281	41	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	281	42	(	(	-LRB-
cord-344093-3bniy5b5	281	43	97	97	CD
cord-344093-3bniy5b5	281	44	,	,	,
cord-344093-3bniy5b5	281	45	167	167	CD
cord-344093-3bniy5b5	281	46	)	)	-RRB-
cord-344093-3bniy5b5	281	47	.	.	.
cord-344093-3bniy5b5	282	1	Additionally	additionally	RB
cord-344093-3bniy5b5	282	2	,	,	,
cord-344093-3bniy5b5	282	3	macrophages	macrophage	NNS
cord-344093-3bniy5b5	282	4	gained	gain	VBN
cord-344093-3bniy5b5	282	5	from	from	IN
cord-344093-3bniy5b5	282	6	bronchoalveolar	bronchoalveolar	NNP
cord-344093-3bniy5b5	282	7	lavages	lavage	NNS
cord-344093-3bniy5b5	282	8	of	of	IN
cord-344093-3bniy5b5	282	9	patients	patient	NNS
cord-344093-3bniy5b5	282	10	presenting	present	VBG
cord-344093-3bniy5b5	282	11	with	with	IN
cord-344093-3bniy5b5	282	12	ARDS	ARDS	NNP
cord-344093-3bniy5b5	282	13	caused	cause	VBN
cord-344093-3bniy5b5	282	14	by	by	IN
cord-344093-3bniy5b5	282	15	the	the	DT
cord-344093-3bniy5b5	282	16	pandemic	pandemic	NN
cord-344093-3bniy5b5	282	17	H1N1/2009	h1n1/2009	NN
cord-344093-3bniy5b5	282	18	virus	virus	NN
cord-344093-3bniy5b5	282	19	strain	strain	NN
cord-344093-3bniy5b5	282	20	showed	show	VBD
cord-344093-3bniy5b5	282	21	high	high	JJ
cord-344093-3bniy5b5	282	22	surface	surface	NN
cord-344093-3bniy5b5	282	23	expression	expression	NN
cord-344093-3bniy5b5	282	24	and	and	CC
cord-344093-3bniy5b5	282	25	release	release	NN
cord-344093-3bniy5b5	282	26	of	of	IN
cord-344093-3bniy5b5	282	27	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	282	28	(	(	-LRB-
cord-344093-3bniy5b5	282	29	10	10	CD
cord-344093-3bniy5b5	282	30	)	)	-RRB-
cord-344093-3bniy5b5	282	31	.	.	.
cord-344093-3bniy5b5	283	1	Another	another	DT
cord-344093-3bniy5b5	283	2	recent	recent	JJ
cord-344093-3bniy5b5	283	3	report	report	NN
cord-344093-3bniy5b5	283	4	demonstrates	demonstrate	VBZ
cord-344093-3bniy5b5	283	5	that	that	IN
cord-344093-3bniy5b5	283	6	in	in	IN
cord-344093-3bniy5b5	283	7	highly	highly	RB
cord-344093-3bniy5b5	283	8	pathogenic	pathogenic	JJ
cord-344093-3bniy5b5	283	9	avian	avian	JJ
cord-344093-3bniy5b5	283	10	influenza	influenza	NN
cord-344093-3bniy5b5	283	11	,	,	,
cord-344093-3bniy5b5	283	12	in	in	IN
cord-344093-3bniy5b5	283	13	addition	addition	NN
cord-344093-3bniy5b5	283	14	to	to	IN
cord-344093-3bniy5b5	283	15	macrophages	macrophage	NNS
cord-344093-3bniy5b5	283	16	also	also	RB
cord-344093-3bniy5b5	283	17	the	the	DT
cord-344093-3bniy5b5	283	18	alveolar	alveolar	JJ
cord-344093-3bniy5b5	283	19	epithelium	epithelium	NN
cord-344093-3bniy5b5	283	20	might	may	MD
cord-344093-3bniy5b5	283	21	be	be	VB
cord-344093-3bniy5b5	283	22	involved	involve	VBN
cord-344093-3bniy5b5	283	23	in	in	IN
cord-344093-3bniy5b5	283	24	causing	cause	VBG
cord-344093-3bniy5b5	283	25	elevated	elevated	JJ
cord-344093-3bniy5b5	283	26	levels	level	NNS
cord-344093-3bniy5b5	283	27	of	of	IN
cord-344093-3bniy5b5	283	28	TRAIL	trail	NN
cord-344093-3bniy5b5	283	29	in	in	IN
cord-344093-3bniy5b5	283	30	the	the	DT
cord-344093-3bniy5b5	283	31	alveolar	alveolar	JJ
cord-344093-3bniy5b5	283	32	space	space	NN
cord-344093-3bniy5b5	283	33	(	(	-LRB-
cord-344093-3bniy5b5	283	34	130	130	CD
cord-344093-3bniy5b5	283	35	)	)	-RRB-
cord-344093-3bniy5b5	283	36	.	.	.
cord-344093-3bniy5b5	284	1	Besides	besides	IN
cord-344093-3bniy5b5	284	2	its	-PRON-	PRP$
cord-344093-3bniy5b5	284	3	role	role	NN
cord-344093-3bniy5b5	284	4	in	in	IN
cord-344093-3bniy5b5	284	5	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	284	6	,	,	,
cord-344093-3bniy5b5	284	7	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	284	8	signaling	signal	VBG
cord-344093-3bniy5b5	284	9	upon	upon	IN
cord-344093-3bniy5b5	284	10	IAV	IAV	NNP
cord-344093-3bniy5b5	284	11	infection	infection	NN
cord-344093-3bniy5b5	284	12	has	have	VBZ
cord-344093-3bniy5b5	284	13	also	also	RB
cord-344093-3bniy5b5	284	14	been	be	VBN
cord-344093-3bniy5b5	284	15	implicated	implicate	VBN
cord-344093-3bniy5b5	284	16	in	in	IN
cord-344093-3bniy5b5	284	17	the	the	DT
cord-344093-3bniy5b5	284	18	induction	induction	NN
cord-344093-3bniy5b5	284	19	of	of	IN
cord-344093-3bniy5b5	284	20	necroptosis	necroptosis	NNP
cord-344093-3bniy5b5	284	21	in	in	IN
cord-344093-3bniy5b5	284	22	fibroblasts	fibroblast	NNS
cord-344093-3bniy5b5	284	23	,	,	,
cord-344093-3bniy5b5	284	24	DCs	dc	NNS
cord-344093-3bniy5b5	284	25	,	,	,
cord-344093-3bniy5b5	284	26	and	and	CC
cord-344093-3bniy5b5	284	27	lung	lung	NN
cord-344093-3bniy5b5	284	28	epithelial	epithelial	JJ
cord-344093-3bniy5b5	284	29	cells	cell	NNS
cord-344093-3bniy5b5	284	30	(	(	-LRB-
cord-344093-3bniy5b5	284	31	146	146	CD
cord-344093-3bniy5b5	284	32	,	,	,
cord-344093-3bniy5b5	284	33	147	147	CD
cord-344093-3bniy5b5	284	34	,	,	,
cord-344093-3bniy5b5	284	35	168	168	CD
cord-344093-3bniy5b5	284	36	)	)	-RRB-
cord-344093-3bniy5b5	284	37	.	.	.
cord-344093-3bniy5b5	285	1	Rodrigue	Rodrigue	NNP
cord-344093-3bniy5b5	285	2	-	-	HYPH
cord-344093-3bniy5b5	285	3	Gervais	Gervais	NNP
cord-344093-3bniy5b5	285	4	et	et	NNP
cord-344093-3bniy5b5	285	5	al	al	NNP
cord-344093-3bniy5b5	285	6	.	.	.
cord-344093-3bniy5b5	286	1	(	(	-LRB-
cord-344093-3bniy5b5	286	2	146	146	CD
cord-344093-3bniy5b5	286	3	)	)	-RRB-
cord-344093-3bniy5b5	286	4	demonstrated	demonstrate	VBD
cord-344093-3bniy5b5	286	5	that	that	IN
cord-344093-3bniy5b5	286	6	lack	lack	NN
cord-344093-3bniy5b5	286	7	of	of	IN
cord-344093-3bniy5b5	286	8	cIPA2	cipa2	NN
cord-344093-3bniy5b5	286	9	promotes	promote	VBZ
cord-344093-3bniy5b5	286	10	RIP3	RIP3	NNP
cord-344093-3bniy5b5	286	11	kinase	kinase	NN
cord-344093-3bniy5b5	286	12	-	-	HYPH
cord-344093-3bniy5b5	286	13	mediated	mediate	VBN
cord-344093-3bniy5b5	286	14	necroptosis	necroptosis	NN
cord-344093-3bniy5b5	286	15	in	in	IN
cord-344093-3bniy5b5	286	16	response	response	NN
cord-344093-3bniy5b5	286	17	to	to	IN
cord-344093-3bniy5b5	286	18	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	286	19	-	-	:
cord-344093-3bniy5b5	286	20	but	but	CC
cord-344093-3bniy5b5	286	21	also	also	RB
cord-344093-3bniy5b5	286	22	the	the	DT
cord-344093-3bniy5b5	286	23	proapoptotic	proapoptotic	JJ
cord-344093-3bniy5b5	286	24	factor	factor	NN
cord-344093-3bniy5b5	286	25	FasLreleased	faslrelease	VBN
cord-344093-3bniy5b5	286	26	from	from	IN
cord-344093-3bniy5b5	286	27	hematopoietic	hematopoietic	JJ
cord-344093-3bniy5b5	286	28	cells	cell	NNS
cord-344093-3bniy5b5	286	29	.	.	.
cord-344093-3bniy5b5	287	1	This	this	DT
cord-344093-3bniy5b5	287	2	contributed	contribute	VBD
cord-344093-3bniy5b5	287	3	to	to	IN
cord-344093-3bniy5b5	287	4	severe	severe	JJ
cord-344093-3bniy5b5	287	5	lung	lung	NN
cord-344093-3bniy5b5	287	6	epithelial	epithelial	NN
cord-344093-3bniy5b5	287	7	degeneration	degeneration	NN
cord-344093-3bniy5b5	287	8	and	and	CC
cord-344093-3bniy5b5	287	9	increased	increase	VBN
cord-344093-3bniy5b5	287	10	mortality	mortality	NN
cord-344093-3bniy5b5	287	11	,	,	,
cord-344093-3bniy5b5	287	12	even	even	RB
cord-344093-3bniy5b5	287	13	though	though	IN
cord-344093-3bniy5b5	287	14	viral	viral	JJ
cord-344093-3bniy5b5	287	15	control	control	NN
cord-344093-3bniy5b5	287	16	was	be	VBD
cord-344093-3bniy5b5	287	17	not	not	RB
cord-344093-3bniy5b5	287	18	compromised	compromise	VBN
cord-344093-3bniy5b5	287	19	.	.	.
cord-344093-3bniy5b5	288	1	Nogusa	Nogusa	NNP
cord-344093-3bniy5b5	288	2	et	et	NNP
cord-344093-3bniy5b5	288	3	al	al	NNP
cord-344093-3bniy5b5	288	4	.	.	.
cord-344093-3bniy5b5	289	1	(	(	-LRB-
cord-344093-3bniy5b5	289	2	147	147	CD
cord-344093-3bniy5b5	289	3	)	)	-RRB-
cord-344093-3bniy5b5	289	4	further	further	RB
cord-344093-3bniy5b5	289	5	elucidated	elucidate	VBD
cord-344093-3bniy5b5	289	6	that	that	IN
cord-344093-3bniy5b5	289	7	IAV	IAV	NNP
cord-344093-3bniy5b5	289	8	-	-	HYPH
cord-344093-3bniy5b5	289	9	induced	induce	VBN
cord-344093-3bniy5b5	289	10	necroptosis	necroptosis	NN
cord-344093-3bniy5b5	289	11	depends	depend	VBZ
cord-344093-3bniy5b5	289	12	on	on	IN
cord-344093-3bniy5b5	289	13	RIP3	RIP3	NNP
cord-344093-3bniy5b5	289	14	kinase	kinase	NN
cord-344093-3bniy5b5	289	15	activation	activation	NN
cord-344093-3bniy5b5	289	16	of	of	IN
cord-344093-3bniy5b5	289	17	MLKL	MLKL	NNP
cord-344093-3bniy5b5	289	18	,	,	,
cord-344093-3bniy5b5	289	19	and	and	CC
cord-344093-3bniy5b5	289	20	that	that	IN
cord-344093-3bniy5b5	289	21	RIP3	RIP3	NNP
cord-344093-3bniy5b5	289	22	kinase	kinase	NN
cord-344093-3bniy5b5	289	23	deficiency	deficiency	NN
cord-344093-3bniy5b5	289	24	,	,	,
cord-344093-3bniy5b5	289	25	similar	similar	JJ
cord-344093-3bniy5b5	289	26	to	to	IN
cord-344093-3bniy5b5	289	27	cIAP2-deficiency	cIAP2-deficiency	NNP
cord-344093-3bniy5b5	289	28	,	,	,
cord-344093-3bniy5b5	289	29	increased	increase	VBN
cord-344093-3bniy5b5	289	30	IAV	iav	NN
cord-344093-3bniy5b5	289	31	-	-	HYPH
cord-344093-3bniy5b5	289	32	susceptibility	susceptibility	NN
cord-344093-3bniy5b5	289	33	in	in	IN
cord-344093-3bniy5b5	289	34	vivo	vivo	NN
cord-344093-3bniy5b5	289	35	.	.	.
cord-344093-3bniy5b5	290	1	In	in	IN
cord-344093-3bniy5b5	290	2	IAV	IAV	NNP
cord-344093-3bniy5b5	290	3	infection	infection	NN
cord-344093-3bniy5b5	290	4	,	,	,
cord-344093-3bniy5b5	290	5	as	as	IN
cord-344093-3bniy5b5	290	6	mentioned	mention	VBN
cord-344093-3bniy5b5	290	7	earlier	early	RBR
cord-344093-3bniy5b5	290	8	,	,	,
cord-344093-3bniy5b5	290	9	DR5	DR5	NNP
cord-344093-3bniy5b5	290	10	expression	expression	NN
cord-344093-3bniy5b5	290	11	is	be	VBZ
cord-344093-3bniy5b5	290	12	elevated	elevate	VBN
cord-344093-3bniy5b5	290	13	on	on	IN
cord-344093-3bniy5b5	290	14	infected	infected	JJ
cord-344093-3bniy5b5	290	15	alveolar	alveolar	JJ
cord-344093-3bniy5b5	290	16	epithelial	epithelial	JJ
cord-344093-3bniy5b5	290	17	cells	cell	NNS
cord-344093-3bniy5b5	290	18	,	,	,
cord-344093-3bniy5b5	290	19	but	but	CC
cord-344093-3bniy5b5	290	20	not	not	RB
cord-344093-3bniy5b5	290	21	in	in	IN
cord-344093-3bniy5b5	290	22	noninfected	noninfected	JJ
cord-344093-3bniy5b5	290	23	cells	cell	NNS
cord-344093-3bniy5b5	290	24	in	in	IN
cord-344093-3bniy5b5	290	25	vivo	vivo	NN
cord-344093-3bniy5b5	290	26	,	,	,
cord-344093-3bniy5b5	290	27	which	which	WDT
cord-344093-3bniy5b5	290	28	might	may	MD
cord-344093-3bniy5b5	290	29	impact	impact	VB
cord-344093-3bniy5b5	290	30	on	on	IN
cord-344093-3bniy5b5	290	31	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	290	32	susceptibility	susceptibility	NN
cord-344093-3bniy5b5	290	33	to	to	IN
cord-344093-3bniy5b5	290	34	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	290	35	induction	induction	NN
cord-344093-3bniy5b5	290	36	(	(	-LRB-
cord-344093-3bniy5b5	290	37	10	10	CD
cord-344093-3bniy5b5	290	38	)	)	-RRB-
cord-344093-3bniy5b5	290	39	.	.	.
cord-344093-3bniy5b5	291	1	However	however	RB
cord-344093-3bniy5b5	291	2	,	,	,
cord-344093-3bniy5b5	291	3	both	both	DT
cord-344093-3bniy5b5	291	4	infected	infect	VBD
cord-344093-3bniy5b5	291	5	as	as	RB
cord-344093-3bniy5b5	291	6	well	well	RB
cord-344093-3bniy5b5	291	7	as	as	IN
cord-344093-3bniy5b5	291	8	neighboring	neighboring	NN
cord-344093-3bniy5b5	291	9	bystander	bystander	NN
cord-344093-3bniy5b5	291	10	cells	cell	NNS
cord-344093-3bniy5b5	291	11	were	be	VBD
cord-344093-3bniy5b5	291	12	found	find	VBN
cord-344093-3bniy5b5	291	13	to	to	TO
cord-344093-3bniy5b5	291	14	be	be	VB
cord-344093-3bniy5b5	291	15	targeted	target	VBN
cord-344093-3bniy5b5	291	16	for	for	IN
cord-344093-3bniy5b5	291	17	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	291	18	induction	induction	NN
cord-344093-3bniy5b5	291	19	by	by	IN
cord-344093-3bniy5b5	291	20	macrophage	macrophage	NN
cord-344093-3bniy5b5	291	21	-	-	HYPH
cord-344093-3bniy5b5	291	22	released	release	VBN
cord-344093-3bniy5b5	291	23	TRAIL	trail	NN
cord-344093-3bniy5b5	291	24	.	.	.
cord-344093-3bniy5b5	292	1	Nonetheless	nonetheless	RB
cord-344093-3bniy5b5	292	2	,	,	,
cord-344093-3bniy5b5	292	3	we	-PRON-	PRP
cord-344093-3bniy5b5	292	4	could	could	MD
cord-344093-3bniy5b5	292	5	recently	recently	RB
cord-344093-3bniy5b5	292	6	show	show	VB
cord-344093-3bniy5b5	292	7	that	that	IN
cord-344093-3bniy5b5	292	8	specifically	specifically	RB
cord-344093-3bniy5b5	292	9	in	in	IN
cord-344093-3bniy5b5	292	10	noninfected	noninfected	JJ
cord-344093-3bniy5b5	292	11	cells	cell	NNS
cord-344093-3bniy5b5	292	12	within	within	IN
cord-344093-3bniy5b5	292	13	the	the	DT
cord-344093-3bniy5b5	292	14	IAV	IAV	NNP
cord-344093-3bniy5b5	292	15	-	-	HYPH
cord-344093-3bniy5b5	292	16	infected	infect	VBN
cord-344093-3bniy5b5	292	17	lung	lung	NN
cord-344093-3bniy5b5	292	18	,	,	,
cord-344093-3bniy5b5	292	19	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	292	20	severely	severely	RB
cord-344093-3bniy5b5	292	21	compromises	compromise	VBZ
cord-344093-3bniy5b5	292	22	the	the	DT
cord-344093-3bniy5b5	292	23	function	function	NN
cord-344093-3bniy5b5	292	24	of	of	IN
cord-344093-3bniy5b5	292	25	the	the	DT
cord-344093-3bniy5b5	292	26	ion	ion	NN
cord-344093-3bniy5b5	292	27	channel	channel	NN
cord-344093-3bniy5b5	293	1	Na	na	UH
cord-344093-3bniy5b5	293	2	,	,	,
cord-344093-3bniy5b5	293	3	K	K	NNP
cord-344093-3bniy5b5	293	4	-	-	HYPH
cord-344093-3bniy5b5	293	5	ATPase	ATPase	NNP
cord-344093-3bniy5b5	293	6	,	,	,
cord-344093-3bniy5b5	293	7	which	which	WDT
cord-344093-3bniy5b5	293	8	was	be	VBD
cord-344093-3bniy5b5	293	9	mediated	mediate	VBN
cord-344093-3bniy5b5	293	10	via	via	IN
cord-344093-3bniy5b5	293	11	induction	induction	NN
cord-344093-3bniy5b5	293	12	of	of	IN
cord-344093-3bniy5b5	293	13	the	the	DT
cord-344093-3bniy5b5	293	14	stress	stress	NN
cord-344093-3bniy5b5	293	15	kinase	kinase	VBN
cord-344093-3bniy5b5	293	16	AMPK	AMPK	NNP
cord-344093-3bniy5b5	293	17	(	(	-LRB-
cord-344093-3bniy5b5	293	18	11	11	CD
cord-344093-3bniy5b5	293	19	)	)	-RRB-
cord-344093-3bniy5b5	293	20	,	,	,
cord-344093-3bniy5b5	293	21	thereby	thereby	RB
cord-344093-3bniy5b5	293	22	potentially	potentially	RB
cord-344093-3bniy5b5	293	23	revealing	reveal	VBG
cord-344093-3bniy5b5	293	24	a	a	DT
cord-344093-3bniy5b5	293	25	cross	cross	NN
cord-344093-3bniy5b5	293	26	-	-	JJ
cord-344093-3bniy5b5	293	27	link	link	NN
cord-344093-3bniy5b5	293	28	to	to	IN
cord-344093-3bniy5b5	293	29	TRAILinduced	trailinduced	JJ
cord-344093-3bniy5b5	293	30	autophagic	autophagic	JJ
cord-344093-3bniy5b5	293	31	cell	cell	NN
cord-344093-3bniy5b5	293	32	stress	stress	NN
cord-344093-3bniy5b5	293	33	pathways	pathway	NNS
cord-344093-3bniy5b5	293	34	in	in	IN
cord-344093-3bniy5b5	293	35	bystander	bystander	NN
cord-344093-3bniy5b5	293	36	cells	cell	NNS
cord-344093-3bniy5b5	293	37	both	both	DT
cord-344093-3bniy5b5	293	38	in	in	IN
cord-344093-3bniy5b5	293	39	vitro	vitro	FW
cord-344093-3bniy5b5	293	40	and	and	CC
cord-344093-3bniy5b5	293	41	in	in	IN
cord-344093-3bniy5b5	293	42	vivo	vivo	NNP
cord-344093-3bniy5b5	293	43	.	.	.
cord-344093-3bniy5b5	294	1	The	the	DT
cord-344093-3bniy5b5	294	2	TRAIL	trail	NN
cord-344093-3bniy5b5	294	3	-	-	HYPH
cord-344093-3bniy5b5	294	4	induced	induce	VBN
cord-344093-3bniy5b5	294	5	and	and	CC
cord-344093-3bniy5b5	294	6	AMPK	AMPK	NNP
cord-344093-3bniy5b5	294	7	-	-	HYPH
cord-344093-3bniy5b5	294	8	mediated	mediate	VBN
cord-344093-3bniy5b5	294	9	downregulation	downregulation	NN
cord-344093-3bniy5b5	294	10	of	of	IN
cord-344093-3bniy5b5	294	11	the	the	DT
cord-344093-3bniy5b5	294	12	Na	Na	NNP
cord-344093-3bniy5b5	294	13	,	,	,
cord-344093-3bniy5b5	294	14	K	K	NNP
cord-344093-3bniy5b5	294	15	-	-	HYPH
cord-344093-3bniy5b5	294	16	ATPase	ATPase	NNP
cord-344093-3bniy5b5	294	17	,	,	,
cord-344093-3bniy5b5	294	18	a	a	DT
cord-344093-3bniy5b5	294	19	major	major	JJ
cord-344093-3bniy5b5	294	20	driver	driver	NN
cord-344093-3bniy5b5	294	21	of	of	IN
cord-344093-3bniy5b5	294	22	vertical	vertical	JJ
cord-344093-3bniy5b5	294	23	ion	ion	NN
cord-344093-3bniy5b5	294	24	and	and	CC
cord-344093-3bniy5b5	294	25	fluid	fluid	JJ
cord-344093-3bniy5b5	294	26	transport	transport	NN
cord-344093-3bniy5b5	294	27	from	from	IN
cord-344093-3bniy5b5	294	28	the	the	DT
cord-344093-3bniy5b5	294	29	alveolar	alveolar	JJ
cord-344093-3bniy5b5	294	30	airspace	airspace	NN
cord-344093-3bniy5b5	294	31	toward	toward	IN
cord-344093-3bniy5b5	294	32	the	the	DT
cord-344093-3bniy5b5	294	33	interstitium	interstitium	NN
cord-344093-3bniy5b5	294	34	,	,	,
cord-344093-3bniy5b5	294	35	resulted	result	VBD
cord-344093-3bniy5b5	294	36	in	in	IN
cord-344093-3bniy5b5	294	37	a	a	DT
cord-344093-3bniy5b5	294	38	reduced	reduce	VBN
cord-344093-3bniy5b5	294	39	capacity	capacity	NN
cord-344093-3bniy5b5	294	40	of	of	IN
cord-344093-3bniy5b5	294	41	IAV	IAV	NNP
cord-344093-3bniy5b5	294	42	-	-	HYPH
cord-344093-3bniy5b5	294	43	infected	infect	VBN
cord-344093-3bniy5b5	294	44	mice	mouse	NNS
cord-344093-3bniy5b5	294	45	to	to	TO
cord-344093-3bniy5b5	294	46	clear	clear	VB
cord-344093-3bniy5b5	294	47	excessive	excessive	JJ
cord-344093-3bniy5b5	294	48	fluid	fluid	NN
cord-344093-3bniy5b5	294	49	from	from	IN
cord-344093-3bniy5b5	294	50	the	the	DT
cord-344093-3bniy5b5	294	51	alveoli	alveolus	NNS
cord-344093-3bniy5b5	294	52	.	.	.
cord-344093-3bniy5b5	295	1	Thus	thus	RB
cord-344093-3bniy5b5	295	2	,	,	,
cord-344093-3bniy5b5	295	3	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	295	4	signaling	signaling	NN
cord-344093-3bniy5b5	295	5	contributes	contribute	VBZ
cord-344093-3bniy5b5	295	6	to	to	IN
cord-344093-3bniy5b5	295	7	intensive	intensive	JJ
cord-344093-3bniy5b5	295	8	edema	edema	NN
cord-344093-3bniy5b5	295	9	formation	formation	NN
cord-344093-3bniy5b5	295	10	,	,	,
cord-344093-3bniy5b5	295	11	a	a	DT
cord-344093-3bniy5b5	295	12	hallmark	hallmark	NN
cord-344093-3bniy5b5	295	13	of	of	IN
cord-344093-3bniy5b5	295	14	disease	disease	NN
cord-344093-3bniy5b5	295	15	in	in	IN
cord-344093-3bniy5b5	295	16	virus	virus	NN
cord-344093-3bniy5b5	295	17	-	-	HYPH
cord-344093-3bniy5b5	295	18	induced	induce	VBN
cord-344093-3bniy5b5	295	19	ARDS	ARDS	NNP
cord-344093-3bniy5b5	295	20	(	(	-LRB-
cord-344093-3bniy5b5	295	21	123	123	CD
cord-344093-3bniy5b5	295	22	)	)	-RRB-
cord-344093-3bniy5b5	295	23	.	.	.
cord-344093-3bniy5b5	296	1	Notably	notably	RB
cord-344093-3bniy5b5	296	2	,	,	,
cord-344093-3bniy5b5	296	3	this	this	DT
cord-344093-3bniy5b5	296	4	effect	effect	NN
cord-344093-3bniy5b5	296	5	of	of	IN
cord-344093-3bniy5b5	296	6	TRAIL	trail	NN
cord-344093-3bniy5b5	296	7	on	on	IN
cord-344093-3bniy5b5	296	8	Na	Na	NNP
cord-344093-3bniy5b5	296	9	,	,	,
cord-344093-3bniy5b5	296	10	K	K	NNP
cord-344093-3bniy5b5	296	11	-	-	HYPH
cord-344093-3bniy5b5	296	12	ATPase	ATPase	NNP
cord-344093-3bniy5b5	296	13	expression	expression	NN
cord-344093-3bniy5b5	296	14	was	be	VBD
cord-344093-3bniy5b5	296	15	induced	induce	VBN
cord-344093-3bniy5b5	296	16	independently	independently	RB
cord-344093-3bniy5b5	296	17	of	of	IN
cord-344093-3bniy5b5	296	18	cell	cell	NN
cord-344093-3bniy5b5	296	19	death	death	NN
cord-344093-3bniy5b5	296	20	pathways	pathway	NNS
cord-344093-3bniy5b5	296	21	elicited	elicit	VBN
cord-344093-3bniy5b5	296	22	by	by	IN
cord-344093-3bniy5b5	296	23	caspases	caspase	NNS
cord-344093-3bniy5b5	296	24	,	,	,
cord-344093-3bniy5b5	296	25	as	as	IN
cord-344093-3bniy5b5	296	26	treatment	treatment	NN
cord-344093-3bniy5b5	296	27	of	of	IN
cord-344093-3bniy5b5	296	28	cells	cell	NNS
cord-344093-3bniy5b5	296	29	and	and	CC
cord-344093-3bniy5b5	296	30	mice	mouse	NNS
cord-344093-3bniy5b5	296	31	with	with	IN
cord-344093-3bniy5b5	296	32	a	a	DT
cord-344093-3bniy5b5	296	33	specific	specific	JJ
cord-344093-3bniy5b5	296	34	caspase-3	caspase-3	NNP
cord-344093-3bniy5b5	296	35	inhibitor	inhibitor	NN
cord-344093-3bniy5b5	296	36	diminished	diminish	VBD
cord-344093-3bniy5b5	296	37	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	296	38	in	in	IN
cord-344093-3bniy5b5	296	39	alveolar	alveolar	JJ
cord-344093-3bniy5b5	296	40	epithelial	epithelial	JJ
cord-344093-3bniy5b5	296	41	cells	cell	NNS
cord-344093-3bniy5b5	296	42	but	but	CC
cord-344093-3bniy5b5	296	43	still	still	RB
cord-344093-3bniy5b5	296	44	allowed	allow	VBN
cord-344093-3bniy5b5	296	45	for	for	IN
cord-344093-3bniy5b5	296	46	the	the	DT
cord-344093-3bniy5b5	296	47	reduction	reduction	NN
cord-344093-3bniy5b5	296	48	of	of	IN
cord-344093-3bniy5b5	296	49	the	the	DT
cord-344093-3bniy5b5	296	50	Na	Na	NNP
cord-344093-3bniy5b5	296	51	,	,	,
cord-344093-3bniy5b5	296	52	K	K	NNP
cord-344093-3bniy5b5	296	53	-	-	HYPH
cord-344093-3bniy5b5	296	54	ATPase	ATPase	NNP
cord-344093-3bniy5b5	296	55	(	(	-LRB-
cord-344093-3bniy5b5	296	56	11	11	CD
cord-344093-3bniy5b5	296	57	)	)	-RRB-
cord-344093-3bniy5b5	296	58	.	.	.
cord-344093-3bniy5b5	297	1	Conclusively	conclusively	RB
cord-344093-3bniy5b5	297	2	,	,	,
cord-344093-3bniy5b5	297	3	treatment	treatment	NN
cord-344093-3bniy5b5	297	4	of	of	IN
cord-344093-3bniy5b5	297	5	IAV	IAV	NNP
cord-344093-3bniy5b5	297	6	-	-	HYPH
cord-344093-3bniy5b5	297	7	infected	infect	VBN
cord-344093-3bniy5b5	297	8	mice	mouse	NNS
cord-344093-3bniy5b5	297	9	with	with	IN
cord-344093-3bniy5b5	297	10	neutralizing	neutralize	VBG
cord-344093-3bniy5b5	297	11	antibodies	antibody	NNS
cord-344093-3bniy5b5	297	12	directed	direct	VBN
cord-344093-3bniy5b5	297	13	against	against	IN
cord-344093-3bniy5b5	297	14	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	297	15	or	or	CC
cord-344093-3bniy5b5	297	16	the	the	DT
cord-344093-3bniy5b5	297	17	abrogation	abrogation	NN
cord-344093-3bniy5b5	297	18	of	of	IN
cord-344093-3bniy5b5	297	19	recruitment	recruitment	NN
cord-344093-3bniy5b5	297	20	of	of	IN
cord-344093-3bniy5b5	297	21	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	297	22	+	+	CC
cord-344093-3bniy5b5	297	23	bone	bone	NN
cord-344093-3bniy5b5	297	24	marrow	marrow	NN
cord-344093-3bniy5b5	297	25	-	-	HYPH
cord-344093-3bniy5b5	297	26	derived	derive	VBN
cord-344093-3bniy5b5	297	27	macrophages	macrophage	NNS
cord-344093-3bniy5b5	297	28	inhibited	inhibit	VBN
cord-344093-3bniy5b5	297	29	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	297	30	of	of	IN
cord-344093-3bniy5b5	297	31	both	both	CC
cord-344093-3bniy5b5	297	32	non	non	JJ
cord-344093-3bniy5b5	297	33	-	-	JJ
cord-344093-3bniy5b5	297	34	infected	infected	JJ
cord-344093-3bniy5b5	297	35	and	and	CC
cord-344093-3bniy5b5	297	36	bystander	bystander	NN
cord-344093-3bniy5b5	297	37	cells	cell	NNS
cord-344093-3bniy5b5	297	38	.	.	.
cord-344093-3bniy5b5	298	1	Thus	thus	RB
cord-344093-3bniy5b5	298	2	,	,	,
cord-344093-3bniy5b5	298	3	lung	lung	NN
cord-344093-3bniy5b5	298	4	leakage	leakage	NN
cord-344093-3bniy5b5	298	5	due	due	IN
cord-344093-3bniy5b5	298	6	to	to	IN
cord-344093-3bniy5b5	298	7	loss	loss	NN
cord-344093-3bniy5b5	298	8	of	of	IN
cord-344093-3bniy5b5	298	9	alveolar	alveolar	JJ
cord-344093-3bniy5b5	298	10	barrier	barrier	NN
cord-344093-3bniy5b5	298	11	function	function	NN
cord-344093-3bniy5b5	298	12	was	be	VBD
cord-344093-3bniy5b5	298	13	reduced	reduce	VBN
cord-344093-3bniy5b5	298	14	,	,	,
cord-344093-3bniy5b5	298	15	whereas	whereas	IN
cord-344093-3bniy5b5	298	16	alveolar	alveolar	JJ
cord-344093-3bniy5b5	298	17	fluid	fluid	JJ
cord-344093-3bniy5b5	298	18	clearance	clearance	NN
cord-344093-3bniy5b5	298	19	capacity	capacity	NN
cord-344093-3bniy5b5	298	20	was	be	VBD
cord-344093-3bniy5b5	298	21	enhanced	enhance	VBN
cord-344093-3bniy5b5	298	22	,	,	,
cord-344093-3bniy5b5	298	23	resulting	result	VBG
cord-344093-3bniy5b5	298	24	in	in	IN
cord-344093-3bniy5b5	298	25	reduced	reduced	JJ
cord-344093-3bniy5b5	298	26	edema	edema	NN
cord-344093-3bniy5b5	298	27	,	,	,
cord-344093-3bniy5b5	298	28	improved	improve	VBN
cord-344093-3bniy5b5	298	29	survival	survival	NN
cord-344093-3bniy5b5	298	30	,	,	,
cord-344093-3bniy5b5	298	31	and	and	CC
cord-344093-3bniy5b5	298	32	outcome	outcome	VB
cord-344093-3bniy5b5	298	33	upon	upon	IN
cord-344093-3bniy5b5	298	34	IAV	IAV	NNP
cord-344093-3bniy5b5	298	35	challenge	challenge	NN
cord-344093-3bniy5b5	298	36	in	in	IN
cord-344093-3bniy5b5	298	37	vivo	vivo	NN
cord-344093-3bniy5b5	298	38	.	.	.
cord-344093-3bniy5b5	299	1	However	however	RB
cord-344093-3bniy5b5	299	2	,	,	,
cord-344093-3bniy5b5	299	3	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	299	4	has	have	VBZ
cord-344093-3bniy5b5	299	5	also	also	RB
cord-344093-3bniy5b5	299	6	been	be	VBN
cord-344093-3bniy5b5	299	7	shown	show	VBN
cord-344093-3bniy5b5	299	8	to	to	TO
cord-344093-3bniy5b5	299	9	be	be	VB
cord-344093-3bniy5b5	299	10	upregulated	upregulate	VBN
cord-344093-3bniy5b5	299	11	on	on	IN
cord-344093-3bniy5b5	299	12	NK	NK	NNP
cord-344093-3bniy5b5	299	13	,	,	,
cord-344093-3bniy5b5	299	14	DC	DC	NNP
cord-344093-3bniy5b5	299	15	,	,	,
cord-344093-3bniy5b5	299	16	and	and	CC
cord-344093-3bniy5b5	299	17	on	on	IN
cord-344093-3bniy5b5	299	18	CD4	CD4	NNP
cord-344093-3bniy5b5	299	19	+	+	CC
cord-344093-3bniy5b5	299	20	and	and	CC
cord-344093-3bniy5b5	299	21	CD8	CD8	NNP
cord-344093-3bniy5b5	299	22	+	+	CC
cord-344093-3bniy5b5	299	23	T	T	NNP
cord-344093-3bniy5b5	299	24	cells	cell	NNS
cord-344093-3bniy5b5	299	25	after	after	IN
cord-344093-3bniy5b5	299	26	IAV	IAV	NNP
cord-344093-3bniy5b5	299	27	infection	infection	NN
cord-344093-3bniy5b5	299	28	(	(	-LRB-
cord-344093-3bniy5b5	299	29	169	169	CD
cord-344093-3bniy5b5	299	30	)	)	-RRB-
cord-344093-3bniy5b5	299	31	.	.	.
cord-344093-3bniy5b5	300	1	Studies	study	NNS
cord-344093-3bniy5b5	300	2	by	by	IN
cord-344093-3bniy5b5	300	3	Brincks	Brincks	NNP
cord-344093-3bniy5b5	300	4	et	et	NNP
cord-344093-3bniy5b5	300	5	al	al	NNP
cord-344093-3bniy5b5	300	6	.	.	NNP
cord-344093-3bniy5b5	300	7	demonstrated	demonstrate	VBD
cord-344093-3bniy5b5	300	8	that	that	IN
cord-344093-3bniy5b5	300	9	especially	especially	RB
cord-344093-3bniy5b5	300	10	CD8	CD8	NNP
cord-344093-3bniy5b5	300	11	+	+	CC
cord-344093-3bniy5b5	300	12	T	T	NNP
cord-344093-3bniy5b5	300	13	involved	involve	VBN
cord-344093-3bniy5b5	300	14	in	in	IN
cord-344093-3bniy5b5	300	15	cytotoxic	cytotoxic	JJ
cord-344093-3bniy5b5	300	16	T	t	NN
cord-344093-3bniy5b5	300	17	cell	cell	NN
cord-344093-3bniy5b5	300	18	responses	response	NNS
cord-344093-3bniy5b5	300	19	toward	toward	IN
cord-344093-3bniy5b5	300	20	IAV	IAV	NNP
cord-344093-3bniy5b5	300	21	and	and	CC
cord-344093-3bniy5b5	300	22	drive	drive	VB
cord-344093-3bniy5b5	300	23	IAV	iav	NN
cord-344093-3bniy5b5	300	24	-	-	HYPH
cord-344093-3bniy5b5	300	25	infected	infect	VBN
cord-344093-3bniy5b5	300	26	cells	cell	NNS
cord-344093-3bniy5b5	300	27	into	into	IN
cord-344093-3bniy5b5	300	28	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	300	29	via	via	IN
cord-344093-3bniy5b5	300	30	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	300	31	,	,	,
cord-344093-3bniy5b5	300	32	thus	thus	RB
cord-344093-3bniy5b5	300	33	contributing	contribute	VBG
cord-344093-3bniy5b5	300	34	to	to	IN
cord-344093-3bniy5b5	300	35	efficient	efficient	JJ
cord-344093-3bniy5b5	300	36	virus	virus	NN
cord-344093-3bniy5b5	300	37	clearance	clearance	NN
cord-344093-3bniy5b5	300	38	(	(	-LRB-
cord-344093-3bniy5b5	300	39	6	6	CD
cord-344093-3bniy5b5	300	40	,	,	,
cord-344093-3bniy5b5	300	41	170	170	CD
cord-344093-3bniy5b5	300	42	)	)	-RRB-
cord-344093-3bniy5b5	300	43	.	.	.
cord-344093-3bniy5b5	301	1	In	in	IN
cord-344093-3bniy5b5	301	2	addition	addition	NN
cord-344093-3bniy5b5	301	3	,	,	,
cord-344093-3bniy5b5	301	4	both	both	DT
cord-344093-3bniy5b5	301	5	FasL	FasL	NNP
cord-344093-3bniy5b5	301	6	and	and	CC
cord-344093-3bniy5b5	301	7	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	301	8	are	be	VBP
cord-344093-3bniy5b5	301	9	involved	involve	VBN
cord-344093-3bniy5b5	301	10	in	in	IN
cord-344093-3bniy5b5	301	11	DC	DC	NNP
cord-344093-3bniy5b5	301	12	-	-	HYPH
cord-344093-3bniy5b5	301	13	mediated	mediate	VBN
cord-344093-3bniy5b5	301	14	CTL	CTL	NNP
cord-344093-3bniy5b5	301	15	activation	activation	NN
cord-344093-3bniy5b5	301	16	and	and	CC
cord-344093-3bniy5b5	301	17	cytotoxicity	cytotoxicity	NN
cord-344093-3bniy5b5	301	18	against	against	IN
cord-344093-3bniy5b5	301	19	IAV	IAV	NNP
cord-344093-3bniy5b5	301	20	-	-	HYPH
cord-344093-3bniy5b5	301	21	infected	infect	VBN
cord-344093-3bniy5b5	301	22	cells	cell	NNS
cord-344093-3bniy5b5	301	23	(	(	-LRB-
cord-344093-3bniy5b5	301	24	6	6	CD
cord-344093-3bniy5b5	301	25	,	,	,
cord-344093-3bniy5b5	301	26	171	171	CD
cord-344093-3bniy5b5	301	27	)	)	-RRB-
cord-344093-3bniy5b5	301	28	.	.	.
cord-344093-3bniy5b5	302	1	Furthermore	furthermore	RB
cord-344093-3bniy5b5	302	2	,	,	,
cord-344093-3bniy5b5	302	3	studies	study	NNS
cord-344093-3bniy5b5	302	4	showed	show	VBD
cord-344093-3bniy5b5	302	5	delayed	delay	VBN
cord-344093-3bniy5b5	302	6	viral	viral	JJ
cord-344093-3bniy5b5	302	7	clearance	clearance	NN
cord-344093-3bniy5b5	302	8	upon	upon	IN
cord-344093-3bniy5b5	302	9	neutralizing	neutralize	VBG
cord-344093-3bniy5b5	302	10	anti	anti	JJ
cord-344093-3bniy5b5	302	11	-	-	JJ
cord-344093-3bniy5b5	302	12	TRAIL	trail	JJ
cord-344093-3bniy5b5	302	13	antibody	antibody	NN
cord-344093-3bniy5b5	302	14	administration	administration	NN
cord-344093-3bniy5b5	302	15	(	(	-LRB-
cord-344093-3bniy5b5	302	16	169	169	CD
cord-344093-3bniy5b5	302	17	,	,	,
cord-344093-3bniy5b5	302	18	172	172	CD
cord-344093-3bniy5b5	302	19	)	)	-RRB-
cord-344093-3bniy5b5	302	20	.	.	.
cord-344093-3bniy5b5	303	1	Our	-PRON-	PRP$
cord-344093-3bniy5b5	303	2	data	datum	NNS
cord-344093-3bniy5b5	303	3	,	,	,
cord-344093-3bniy5b5	303	4	however	however	RB
cord-344093-3bniy5b5	303	5	,	,	,
cord-344093-3bniy5b5	303	6	demonstrate	demonstrate	VBP
cord-344093-3bniy5b5	303	7	that	that	IN
cord-344093-3bniy5b5	303	8	the	the	DT
cord-344093-3bniy5b5	303	9	transfer	transfer	NN
cord-344093-3bniy5b5	303	10	of	of	IN
cord-344093-3bniy5b5	303	11	TRAIL	trail	NN
cord-344093-3bniy5b5	303	12	-	-	HYPH
cord-344093-3bniy5b5	303	13	deficient	deficient	JJ
cord-344093-3bniy5b5	303	14	bone	bone	NN
cord-344093-3bniy5b5	303	15	marrow	marrow	NN
cord-344093-3bniy5b5	303	16	into	into	IN
cord-344093-3bniy5b5	303	17	irradiated	irradiate	VBN
cord-344093-3bniy5b5	303	18	wild	wild	JJ
cord-344093-3bniy5b5	303	19	-	-	HYPH
cord-344093-3bniy5b5	303	20	type	type	NN
cord-344093-3bniy5b5	303	21	mice	mice	NN
cord-344093-3bniy5b5	303	22	,	,	,
cord-344093-3bniy5b5	303	23	resulting	result	VBG
cord-344093-3bniy5b5	303	24	in	in	IN
cord-344093-3bniy5b5	303	25	loss	loss	NN
cord-344093-3bniy5b5	303	26	of	of	IN
cord-344093-3bniy5b5	303	27	TRAIL	trail	NN
cord-344093-3bniy5b5	303	28	production	production	NN
cord-344093-3bniy5b5	303	29	by	by	IN
cord-344093-3bniy5b5	303	30	bone	bone	NN
cord-344093-3bniy5b5	303	31	marrow	marrow	NN
cord-344093-3bniy5b5	303	32	-	-	HYPH
cord-344093-3bniy5b5	303	33	derived	derive	VBN
cord-344093-3bniy5b5	303	34	macrophages	macrophage	NNS
cord-344093-3bniy5b5	303	35	upon	upon	IN
cord-344093-3bniy5b5	303	36	IAV	IAV	NNP
cord-344093-3bniy5b5	303	37	infection	infection	NN
cord-344093-3bniy5b5	303	38	,	,	,
cord-344093-3bniy5b5	303	39	does	do	VBZ
cord-344093-3bniy5b5	303	40	not	not	RB
cord-344093-3bniy5b5	303	41	impact	impact	VB
cord-344093-3bniy5b5	303	42	on	on	IN
cord-344093-3bniy5b5	303	43	the	the	DT
cord-344093-3bniy5b5	303	44	capacity	capacity	NN
cord-344093-3bniy5b5	303	45	to	to	TO
cord-344093-3bniy5b5	303	46	fully	fully	RB
cord-344093-3bniy5b5	303	47	clear	clear	JJ
cord-344093-3bniy5b5	303	48	viral	viral	JJ
cord-344093-3bniy5b5	303	49	particles	particle	NNS
cord-344093-3bniy5b5	303	50	from	from	IN
cord-344093-3bniy5b5	303	51	the	the	DT
cord-344093-3bniy5b5	303	52	lung	lung	NN
cord-344093-3bniy5b5	303	53	at	at	IN
cord-344093-3bniy5b5	303	54	day	day	NN
cord-344093-3bniy5b5	303	55	7	7	CD
cord-344093-3bniy5b5	303	56	after	after	IN
cord-344093-3bniy5b5	303	57	infection	infection	NN
cord-344093-3bniy5b5	303	58	,	,	,
cord-344093-3bniy5b5	303	59	suggesting	suggest	VBG
cord-344093-3bniy5b5	303	60	that	that	IN
cord-344093-3bniy5b5	303	61	other	other	JJ
cord-344093-3bniy5b5	303	62	compensatory	compensatory	JJ
cord-344093-3bniy5b5	303	63	mechanisms	mechanism	NNS
cord-344093-3bniy5b5	303	64	are	be	VBP
cord-344093-3bniy5b5	303	65	recruited	recruit	VBN
cord-344093-3bniy5b5	303	66	to	to	TO
cord-344093-3bniy5b5	303	67	guarantee	guarantee	VB
cord-344093-3bniy5b5	303	68	viral	viral	JJ
cord-344093-3bniy5b5	303	69	clearance	clearance	NN
cord-344093-3bniy5b5	303	70	(	(	-LRB-
cord-344093-3bniy5b5	303	71	10	10	CD
cord-344093-3bniy5b5	303	72	)	)	-RRB-
cord-344093-3bniy5b5	303	73	.	.	.
cord-344093-3bniy5b5	304	1	Taken	take	VBN
cord-344093-3bniy5b5	304	2	together	together	RB
cord-344093-3bniy5b5	304	3	,	,	,
cord-344093-3bniy5b5	304	4	in	in	IN
cord-344093-3bniy5b5	304	5	IAV	IAV	NNP
cord-344093-3bniy5b5	304	6	infection	infection	NN
cord-344093-3bniy5b5	304	7	,	,	,
cord-344093-3bniy5b5	304	8	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	304	9	acts	act	VBZ
cord-344093-3bniy5b5	304	10	both	both	DT
cord-344093-3bniy5b5	304	11	as	as	IN
cord-344093-3bniy5b5	304	12	an	an	DT
cord-344093-3bniy5b5	304	13	important	important	JJ
cord-344093-3bniy5b5	304	14	mediator	mediator	NN
cord-344093-3bniy5b5	304	15	of	of	IN
cord-344093-3bniy5b5	304	16	infected	infected	JJ
cord-344093-3bniy5b5	304	17	cell	cell	NN
cord-344093-3bniy5b5	304	18	killing	killing	NN
cord-344093-3bniy5b5	304	19	but	but	CC
cord-344093-3bniy5b5	304	20	particularly	particularly	RB
cord-344093-3bniy5b5	304	21	as	as	IN
cord-344093-3bniy5b5	304	22	a	a	DT
cord-344093-3bniy5b5	304	23	detrimental	detrimental	JJ
cord-344093-3bniy5b5	304	24	factor	factor	NN
cord-344093-3bniy5b5	304	25	contributing	contribute	VBG
cord-344093-3bniy5b5	304	26	to	to	IN
cord-344093-3bniy5b5	304	27	tissue	tissue	NN
cord-344093-3bniy5b5	304	28	injury	injury	NN
cord-344093-3bniy5b5	304	29	and	and	CC
cord-344093-3bniy5b5	304	30	impaired	impaired	JJ
cord-344093-3bniy5b5	304	31	inflammation	inflammation	NN
cord-344093-3bniy5b5	304	32	resolution	resolution	NN
cord-344093-3bniy5b5	304	33	when	when	WRB
cord-344093-3bniy5b5	304	34	released	release	VBN
cord-344093-3bniy5b5	304	35	in	in	IN
cord-344093-3bniy5b5	304	36	excessive	excessive	JJ
cord-344093-3bniy5b5	304	37	amounts	amount	NNS
cord-344093-3bniy5b5	304	38	by	by	IN
cord-344093-3bniy5b5	304	39	recruited	recruit	VBN
cord-344093-3bniy5b5	304	40	immune	immune	JJ
cord-344093-3bniy5b5	304	41	cells	cell	NNS
cord-344093-3bniy5b5	304	42	.	.	.
cord-344093-3bniy5b5	305	1	Respiratory	respiratory	JJ
cord-344093-3bniy5b5	305	2	syncytial	syncytial	JJ
cord-344093-3bniy5b5	305	3	virus	virus	NN
cord-344093-3bniy5b5	305	4	is	be	VBZ
cord-344093-3bniy5b5	305	5	an	an	DT
cord-344093-3bniy5b5	305	6	important	important	JJ
cord-344093-3bniy5b5	305	7	cause	cause	NN
cord-344093-3bniy5b5	305	8	of	of	IN
cord-344093-3bniy5b5	305	9	respiratory	respiratory	JJ
cord-344093-3bniy5b5	305	10	tract	tract	NN
cord-344093-3bniy5b5	305	11	infections	infection	NNS
cord-344093-3bniy5b5	305	12	especially	especially	RB
cord-344093-3bniy5b5	305	13	in	in	IN
cord-344093-3bniy5b5	305	14	children	child	NNS
cord-344093-3bniy5b5	305	15	worldwide	worldwide	RB
cord-344093-3bniy5b5	305	16	.	.	.
cord-344093-3bniy5b5	306	1	Generally	generally	RB
cord-344093-3bniy5b5	306	2	,	,	,
cord-344093-3bniy5b5	306	3	there	there	EX
cord-344093-3bniy5b5	306	4	seem	seem	VBP
cord-344093-3bniy5b5	306	5	to	to	TO
cord-344093-3bniy5b5	306	6	be	be	VB
cord-344093-3bniy5b5	306	7	virus	virus	NN
cord-344093-3bniy5b5	306	8	-	-	HYPH
cord-344093-3bniy5b5	306	9	elicited	elicit	VBN
cord-344093-3bniy5b5	306	10	anti	anti	JJ
cord-344093-3bniy5b5	306	11	-	-	JJ
cord-344093-3bniy5b5	306	12	apoptotic	apoptotic	JJ
cord-344093-3bniy5b5	306	13	mechanisms	mechanism	NNS
cord-344093-3bniy5b5	306	14	active	active	JJ
cord-344093-3bniy5b5	306	15	in	in	IN
cord-344093-3bniy5b5	306	16	the	the	DT
cord-344093-3bniy5b5	306	17	lung	lung	NN
cord-344093-3bniy5b5	306	18	epithelium	epithelium	NN
cord-344093-3bniy5b5	306	19	,	,	,
cord-344093-3bniy5b5	306	20	as	as	IN
cord-344093-3bniy5b5	306	21	RSV	RSV	NNP
cord-344093-3bniy5b5	306	22	-	-	HYPH
cord-344093-3bniy5b5	306	23	infected	infect	VBN
cord-344093-3bniy5b5	306	24	primary	primary	JJ
cord-344093-3bniy5b5	306	25	human	human	JJ
cord-344093-3bniy5b5	306	26	airway	airway	NN
cord-344093-3bniy5b5	306	27	cells	cell	NNS
cord-344093-3bniy5b5	306	28	show	show	VBP
cord-344093-3bniy5b5	306	29	a	a	DT
cord-344093-3bniy5b5	306	30	minimal	minimal	JJ
cord-344093-3bniy5b5	306	31	cytopathic	cytopathic	JJ
cord-344093-3bniy5b5	306	32	effect	effect	NN
cord-344093-3bniy5b5	306	33	(	(	-LRB-
cord-344093-3bniy5b5	306	34	173	173	CD
cord-344093-3bniy5b5	306	35	)	)	-RRB-
cord-344093-3bniy5b5	306	36	.	.	.
cord-344093-3bniy5b5	307	1	However	however	RB
cord-344093-3bniy5b5	307	2	,	,	,
cord-344093-3bniy5b5	307	3	several	several	JJ
cord-344093-3bniy5b5	307	4	cell	cell	NN
cord-344093-3bniy5b5	307	5	lines	line	NNS
cord-344093-3bniy5b5	307	6	including	include	VBG
cord-344093-3bniy5b5	307	7	small	small	JJ
cord-344093-3bniy5b5	307	8	airway	airway	NN
cord-344093-3bniy5b5	307	9	cells	cell	NNS
cord-344093-3bniy5b5	307	10	,	,	,
cord-344093-3bniy5b5	307	11	primary	primary	JJ
cord-344093-3bniy5b5	307	12	tracheal	tracheal	JJ
cord-344093-3bniy5b5	307	13	-	-	HYPH
cord-344093-3bniy5b5	307	14	bronchial	bronchial	JJ
cord-344093-3bniy5b5	307	15	cells	cell	NNS
cord-344093-3bniy5b5	307	16	,	,	,
cord-344093-3bniy5b5	307	17	and	and	CC
cord-344093-3bniy5b5	307	18	A549	a549	JJ
cord-344093-3bniy5b5	307	19	and	and	CC
cord-344093-3bniy5b5	307	20	HEp-2	HEp-2	NNP
cord-344093-3bniy5b5	307	21	showed	show	VBD
cord-344093-3bniy5b5	307	22	increased	increased	JJ
cord-344093-3bniy5b5	307	23	expression	expression	NN
cord-344093-3bniy5b5	307	24	of	of	IN
cord-344093-3bniy5b5	307	25	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	307	26	and	and	CC
cord-344093-3bniy5b5	307	27	its	-PRON-	PRP$
cord-344093-3bniy5b5	307	28	ligands	ligand	NNS
cord-344093-3bniy5b5	307	29	DR4	dr4	VBP
cord-344093-3bniy5b5	307	30	and	and	CC
cord-344093-3bniy5b5	307	31	DR5	DR5	NNP
cord-344093-3bniy5b5	307	32	in	in	IN
cord-344093-3bniy5b5	307	33	an	an	DT
cord-344093-3bniy5b5	307	34	in	in	FW
cord-344093-3bniy5b5	307	35	vitro	vitro	FW
cord-344093-3bniy5b5	307	36	RSV	RSV	NNP
cord-344093-3bniy5b5	307	37	infection	infection	NN
cord-344093-3bniy5b5	307	38	model	model	NN
cord-344093-3bniy5b5	307	39	(	(	-LRB-
cord-344093-3bniy5b5	307	40	174	174	CD
cord-344093-3bniy5b5	307	41	)	)	-RRB-
cord-344093-3bniy5b5	307	42	.	.	.
cord-344093-3bniy5b5	308	1	Moreover	moreover	RB
cord-344093-3bniy5b5	308	2	,	,	,
cord-344093-3bniy5b5	308	3	soluble	soluble	JJ
cord-344093-3bniy5b5	308	4	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	308	5	released	release	VBN
cord-344093-3bniy5b5	308	6	from	from	IN
cord-344093-3bniy5b5	308	7	leukocytes	leukocyte	NNS
cord-344093-3bniy5b5	308	8	was	be	VBD
cord-344093-3bniy5b5	308	9	elevated	elevate	VBN
cord-344093-3bniy5b5	308	10	in	in	IN
cord-344093-3bniy5b5	308	11	the	the	DT
cord-344093-3bniy5b5	308	12	bronchoalveolar	bronchoalveolar	NNP
cord-344093-3bniy5b5	308	13	lavage	lavage	NN
cord-344093-3bniy5b5	308	14	fluid	fluid	NN
cord-344093-3bniy5b5	308	15	of	of	IN
cord-344093-3bniy5b5	308	16	patients	patient	NNS
cord-344093-3bniy5b5	308	17	with	with	IN
cord-344093-3bniy5b5	308	18	RSV	RSV	NNP
cord-344093-3bniy5b5	308	19	-	-	HYPH
cord-344093-3bniy5b5	308	20	associated	associate	VBN
cord-344093-3bniy5b5	308	21	respiratory	respiratory	JJ
cord-344093-3bniy5b5	308	22	failure	failure	NN
cord-344093-3bniy5b5	308	23	,	,	,
cord-344093-3bniy5b5	308	24	suggesting	suggest	VBG
cord-344093-3bniy5b5	308	25	that	that	IN
cord-344093-3bniy5b5	308	26	similar	similar	JJ
cord-344093-3bniy5b5	308	27	to	to	IN
cord-344093-3bniy5b5	308	28	IAV	IAV	NNP
cord-344093-3bniy5b5	308	29	,	,	,
cord-344093-3bniy5b5	308	30	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	308	31	contributes	contribute	VBZ
cord-344093-3bniy5b5	308	32	to	to	IN
cord-344093-3bniy5b5	308	33	RSV	RSV	NNP
cord-344093-3bniy5b5	308	34	-	-	HYPH
cord-344093-3bniy5b5	308	35	induced	induce	VBN
cord-344093-3bniy5b5	308	36	epithelial	epithelial	JJ
cord-344093-3bniy5b5	308	37	injury	injury	NN
cord-344093-3bniy5b5	308	38	and	and	CC
cord-344093-3bniy5b5	308	39	disease	disease	NN
cord-344093-3bniy5b5	308	40	progression	progression	NN
cord-344093-3bniy5b5	308	41	(	(	-LRB-
cord-344093-3bniy5b5	308	42	137	137	CD
cord-344093-3bniy5b5	308	43	)	)	-RRB-
cord-344093-3bniy5b5	308	44	.	.	.
cord-344093-3bniy5b5	309	1	Also	also	RB
cord-344093-3bniy5b5	309	2	in	in	IN
cord-344093-3bniy5b5	309	3	CoV	cov	NN
cord-344093-3bniy5b5	309	4	respiratory	respiratory	JJ
cord-344093-3bniy5b5	309	5	tract	tract	NN
cord-344093-3bniy5b5	309	6	infection	infection	NN
cord-344093-3bniy5b5	309	7	,	,	,
cord-344093-3bniy5b5	309	8	TRAIL	trail	NN
cord-344093-3bniy5b5	309	9	levels	level	NNS
cord-344093-3bniy5b5	309	10	,	,	,
cord-344093-3bniy5b5	309	11	but	but	CC
cord-344093-3bniy5b5	309	12	less	less	RBR
cord-344093-3bniy5b5	309	13	so	so	RB
cord-344093-3bniy5b5	309	14	FasL	FasL	NNP
cord-344093-3bniy5b5	309	15	,	,	,
cord-344093-3bniy5b5	309	16	have	have	VBP
cord-344093-3bniy5b5	309	17	been	be	VBN
cord-344093-3bniy5b5	309	18	reported	report	VBN
cord-344093-3bniy5b5	309	19	to	to	TO
cord-344093-3bniy5b5	309	20	be	be	VB
cord-344093-3bniy5b5	309	21	markedly	markedly	RB
cord-344093-3bniy5b5	309	22	elevated	elevate	VBN
cord-344093-3bniy5b5	309	23	(	(	-LRB-
cord-344093-3bniy5b5	309	24	175	175	CD
cord-344093-3bniy5b5	309	25	,	,	,
cord-344093-3bniy5b5	309	26	176	176	CD
cord-344093-3bniy5b5	309	27	)	)	-RRB-
cord-344093-3bniy5b5	309	28	.	.	.
cord-344093-3bniy5b5	310	1	For	for	IN
cord-344093-3bniy5b5	310	2	SARS	SARS	NNP
cord-344093-3bniy5b5	310	3	-	-	HYPH
cord-344093-3bniy5b5	310	4	CoV	CoV	NNP
cord-344093-3bniy5b5	310	5	that	that	WDT
cord-344093-3bniy5b5	310	6	presents	present	VBZ
cord-344093-3bniy5b5	310	7	with	with	IN
cord-344093-3bniy5b5	310	8	a	a	DT
cord-344093-3bniy5b5	310	9	severe	severe	JJ
cord-344093-3bniy5b5	310	10	damage	damage	NN
cord-344093-3bniy5b5	310	11	to	to	IN
cord-344093-3bniy5b5	310	12	both	both	CC
cord-344093-3bniy5b5	310	13	the	the	DT
cord-344093-3bniy5b5	310	14	upper	upper	JJ
cord-344093-3bniy5b5	310	15	and	and	CC
cord-344093-3bniy5b5	310	16	lower	low	JJR
cord-344093-3bniy5b5	310	17	respiratory	respiratory	JJ
cord-344093-3bniy5b5	310	18	tract	tract	NN
cord-344093-3bniy5b5	310	19	(	(	-LRB-
cord-344093-3bniy5b5	310	20	177	177	CD
cord-344093-3bniy5b5	310	21	)	)	-RRB-
cord-344093-3bniy5b5	310	22	,	,	,
cord-344093-3bniy5b5	310	23	especially	especially	RB
cord-344093-3bniy5b5	310	24	DCs	DCs	NNP
cord-344093-3bniy5b5	310	25	respond	respond	VBP
cord-344093-3bniy5b5	310	26	with	with	IN
cord-344093-3bniy5b5	310	27	a	a	DT
cord-344093-3bniy5b5	310	28	strong	strong	JJ
cord-344093-3bniy5b5	310	29	induction	induction	NN
cord-344093-3bniy5b5	310	30	of	of	IN
cord-344093-3bniy5b5	310	31	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	310	32	production	production	NN
cord-344093-3bniy5b5	310	33	,	,	,
cord-344093-3bniy5b5	310	34	which	which	WDT
cord-344093-3bniy5b5	310	35	was	be	VBD
cord-344093-3bniy5b5	310	36	suggested	suggest	VBN
cord-344093-3bniy5b5	310	37	to	to	TO
cord-344093-3bniy5b5	310	38	correlate	correlate	VB
cord-344093-3bniy5b5	310	39	to	to	IN
cord-344093-3bniy5b5	310	40	increased	increase	VBN
cord-344093-3bniy5b5	310	41	cellular	cellular	JJ
cord-344093-3bniy5b5	310	42	lung	lung	NN
cord-344093-3bniy5b5	310	43	infiltrations	infiltration	NNS
cord-344093-3bniy5b5	310	44	present	present	JJ
cord-344093-3bniy5b5	310	45	in	in	IN
cord-344093-3bniy5b5	310	46	SARS	SARS	NNP
cord-344093-3bniy5b5	310	47	-	-	HYPH
cord-344093-3bniy5b5	310	48	CoV	CoV	NNP
cord-344093-3bniy5b5	310	49	patients	patient	NNS
cord-344093-3bniy5b5	310	50	(	(	-LRB-
cord-344093-3bniy5b5	310	51	175	175	CD
cord-344093-3bniy5b5	310	52	)	)	-RRB-
cord-344093-3bniy5b5	310	53	.	.	.
cord-344093-3bniy5b5	311	1	Interestingly	interestingly	RB
cord-344093-3bniy5b5	311	2	,	,	,
cord-344093-3bniy5b5	311	3	SARS	SARS	NNP
cord-344093-3bniy5b5	311	4	-	-	HYPH
cord-344093-3bniy5b5	311	5	CoV	CoV	NNP
cord-344093-3bniy5b5	311	6	infection	infection	NN
cord-344093-3bniy5b5	311	7	drives	drive	VBZ
cord-344093-3bniy5b5	311	8	cells	cell	NNS
cord-344093-3bniy5b5	311	9	into	into	IN
cord-344093-3bniy5b5	311	10	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	311	11	by	by	IN
cord-344093-3bniy5b5	311	12	a	a	DT
cord-344093-3bniy5b5	311	13	PKR	PKR	NNP
cord-344093-3bniy5b5	311	14	-	-	HYPH
cord-344093-3bniy5b5	311	15	driven	drive	VBN
cord-344093-3bniy5b5	311	16	but	but	CC
cord-344093-3bniy5b5	311	17	eIF2α	eif2α	JJ
cord-344093-3bniy5b5	311	18	-	-	HYPH
cord-344093-3bniy5b5	311	19	independent	independent	JJ
cord-344093-3bniy5b5	311	20	pathway	pathway	NN
cord-344093-3bniy5b5	311	21	(	(	-LRB-
cord-344093-3bniy5b5	311	22	178	178	CD
cord-344093-3bniy5b5	311	23	)	)	-RRB-
cord-344093-3bniy5b5	311	24	,	,	,
cord-344093-3bniy5b5	311	25	which	which	WDT
cord-344093-3bniy5b5	311	26	might	may	MD
cord-344093-3bniy5b5	311	27	-	-	HYPH
cord-344093-3bniy5b5	311	28	similarly	similarly	RB
cord-344093-3bniy5b5	311	29	as	as	IN
cord-344093-3bniy5b5	311	30	seen	see	VBN
cord-344093-3bniy5b5	311	31	in	in	IN
cord-344093-3bniy5b5	311	32	IAV	IAV	NNP
cord-344093-3bniy5b5	311	33	infection	infection	NN
cord-344093-3bniy5b5	311	34	-	-	:
cord-344093-3bniy5b5	311	35	suggest	suggest	VBP
cord-344093-3bniy5b5	311	36	a	a	DT
cord-344093-3bniy5b5	311	37	PKR	PKR	NNP
cord-344093-3bniy5b5	311	38	-	-	HYPH
cord-344093-3bniy5b5	311	39	induced	induce	VBN
cord-344093-3bniy5b5	311	40	and	and	CC
cord-344093-3bniy5b5	311	41	autocrine	autocrine	NN
cord-344093-3bniy5b5	311	42	/	/	SYM
cord-344093-3bniy5b5	311	43	paracrine	paracrine	NN
cord-344093-3bniy5b5	311	44	executed	execute	VBN
cord-344093-3bniy5b5	311	45	activation	activation	NN
cord-344093-3bniy5b5	311	46	of	of	IN
cord-344093-3bniy5b5	311	47	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	311	48	.	.	.
cord-344093-3bniy5b5	312	1	Also	also	RB
cord-344093-3bniy5b5	312	2	MERS	MERS	NNP
cord-344093-3bniy5b5	312	3	-	-	HYPH
cord-344093-3bniy5b5	312	4	CoV	CoV	NNP
cord-344093-3bniy5b5	312	5	,	,	,
cord-344093-3bniy5b5	312	6	which	which	WDT
cord-344093-3bniy5b5	312	7	causes	cause	VBZ
cord-344093-3bniy5b5	312	8	pneumonia	pneumonia	NN
cord-344093-3bniy5b5	312	9	and	and	CC
cord-344093-3bniy5b5	312	10	respiratory	respiratory	JJ
cord-344093-3bniy5b5	312	11	failure	failure	NN
cord-344093-3bniy5b5	312	12	,	,	,
cord-344093-3bniy5b5	312	13	has	have	VBZ
cord-344093-3bniy5b5	312	14	been	be	VBN
cord-344093-3bniy5b5	312	15	demonstrated	demonstrate	VBN
cord-344093-3bniy5b5	312	16	to	to	TO
cord-344093-3bniy5b5	312	17	induce	induce	VB
cord-344093-3bniy5b5	312	18	profound	profound	JJ
cord-344093-3bniy5b5	312	19	cell	cell	NN
cord-344093-3bniy5b5	312	20	death	death	NN
cord-344093-3bniy5b5	312	21	within	within	IN
cord-344093-3bniy5b5	312	22	24	24	CD
cord-344093-3bniy5b5	312	23	h	h	NN
cord-344093-3bniy5b5	312	24	of	of	IN
cord-344093-3bniy5b5	312	25	infection	infection	NN
cord-344093-3bniy5b5	312	26	,	,	,
cord-344093-3bniy5b5	312	27	irrespective	irrespective	RB
cord-344093-3bniy5b5	312	28	of	of	IN
cord-344093-3bniy5b5	312	29	viral	viral	JJ
cord-344093-3bniy5b5	312	30	titers	titer	NNS
cord-344093-3bniy5b5	312	31	produced	produce	VBN
cord-344093-3bniy5b5	312	32	by	by	IN
cord-344093-3bniy5b5	312	33	the	the	DT
cord-344093-3bniy5b5	312	34	infected	infected	JJ
cord-344093-3bniy5b5	312	35	cells	cell	NNS
cord-344093-3bniy5b5	312	36	.	.	.
cord-344093-3bniy5b5	313	1	However	however	RB
cord-344093-3bniy5b5	313	2	,	,	,
cord-344093-3bniy5b5	313	3	type	type	NN
cord-344093-3bniy5b5	313	4	I	-PRON-	PRP
cord-344093-3bniy5b5	313	5	IFN	IFN	NNP
cord-344093-3bniy5b5	313	6	expression	expression	NN
cord-344093-3bniy5b5	313	7	is	be	VBZ
cord-344093-3bniy5b5	313	8	strongly	strongly	RB
cord-344093-3bniy5b5	313	9	reduced	reduce	VBN
cord-344093-3bniy5b5	313	10	in	in	IN
cord-344093-3bniy5b5	313	11	MERS	MERS	NNP
cord-344093-3bniy5b5	313	12	-	-	HYPH
cord-344093-3bniy5b5	313	13	CoV	CoV	NNP
cord-344093-3bniy5b5	313	14	in	in	IN
cord-344093-3bniy5b5	313	15	comparison	comparison	NN
cord-344093-3bniy5b5	313	16	to	to	IN
cord-344093-3bniy5b5	313	17	seasonal	seasonal	JJ
cord-344093-3bniy5b5	313	18	human	human	JJ
cord-344093-3bniy5b5	313	19	CoV	cov	NN
cord-344093-3bniy5b5	313	20	in	in	IN
cord-344093-3bniy5b5	313	21	in	in	IN
cord-344093-3bniy5b5	313	22	vitro	vitro	FW
cord-344093-3bniy5b5	313	23	infection	infection	NN
cord-344093-3bniy5b5	313	24	models	model	NNS
cord-344093-3bniy5b5	313	25	,	,	,
cord-344093-3bniy5b5	313	26	including	include	VBG
cord-344093-3bniy5b5	313	27	human	human	JJ
cord-344093-3bniy5b5	313	28	monocyte	monocyte	NNP
cord-344093-3bniy5b5	313	29	-	-	HYPH
cord-344093-3bniy5b5	313	30	derived	derive	VBN
cord-344093-3bniy5b5	313	31	macrophages	macrophage	NNS
cord-344093-3bniy5b5	313	32	,	,	,
cord-344093-3bniy5b5	313	33	Calu-3	Calu-3	NNP
cord-344093-3bniy5b5	313	34	,	,	,
cord-344093-3bniy5b5	313	35	and	and	CC
cord-344093-3bniy5b5	313	36	human	human	JJ
cord-344093-3bniy5b5	313	37	lung	lung	NN
cord-344093-3bniy5b5	313	38	fibroblasts	fibroblast	NNS
cord-344093-3bniy5b5	313	39	(	(	-LRB-
cord-344093-3bniy5b5	313	40	179	179	CD
cord-344093-3bniy5b5	313	41	,	,	,
cord-344093-3bniy5b5	313	42	180	180	CD
cord-344093-3bniy5b5	313	43	)	)	-RRB-
cord-344093-3bniy5b5	313	44	,	,	,
cord-344093-3bniy5b5	313	45	which	which	WDT
cord-344093-3bniy5b5	313	46	might	may	MD
cord-344093-3bniy5b5	313	47	also	also	RB
cord-344093-3bniy5b5	313	48	dampen	dampen	VB
cord-344093-3bniy5b5	313	49	downstream	downstream	JJ
cord-344093-3bniy5b5	313	50	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	313	51	induction	induction	NN
cord-344093-3bniy5b5	313	52	.	.	.
cord-344093-3bniy5b5	314	1	Therefore	therefore	RB
cord-344093-3bniy5b5	314	2	,	,	,
cord-344093-3bniy5b5	314	3	the	the	DT
cord-344093-3bniy5b5	314	4	exact	exact	JJ
cord-344093-3bniy5b5	314	5	mechanism	mechanism	NN
cord-344093-3bniy5b5	314	6	by	by	IN
cord-344093-3bniy5b5	314	7	which	which	WDT
cord-344093-3bniy5b5	314	8	MERS	MERS	NNP
cord-344093-3bniy5b5	314	9	-	-	HYPH
cord-344093-3bniy5b5	314	10	CoV	CoV	NNP
cord-344093-3bniy5b5	314	11	promotes	promote	VBZ
cord-344093-3bniy5b5	314	12	cell	cell	NN
cord-344093-3bniy5b5	314	13	death	death	NN
cord-344093-3bniy5b5	314	14	remains	remain	VBZ
cord-344093-3bniy5b5	314	15	to	to	TO
cord-344093-3bniy5b5	314	16	be	be	VB
cord-344093-3bniy5b5	314	17	investigated	investigate	VBN
cord-344093-3bniy5b5	314	18	.	.	.
cord-344093-3bniy5b5	315	1	Recurrently	recurrently	RB
cord-344093-3bniy5b5	315	2	,	,	,
cord-344093-3bniy5b5	315	3	viral	viral	JJ
cord-344093-3bniy5b5	315	4	infections	infection	NNS
cord-344093-3bniy5b5	315	5	of	of	IN
cord-344093-3bniy5b5	315	6	the	the	DT
cord-344093-3bniy5b5	315	7	respiratory	respiratory	JJ
cord-344093-3bniy5b5	315	8	tract	tract	NN
cord-344093-3bniy5b5	315	9	are	be	VBP
cord-344093-3bniy5b5	315	10	followed	follow	VBN
cord-344093-3bniy5b5	315	11	by	by	IN
cord-344093-3bniy5b5	315	12	outgrowth	outgrowth	NN
cord-344093-3bniy5b5	315	13	of	of	IN
cord-344093-3bniy5b5	315	14	colonizing	colonize	VBG
cord-344093-3bniy5b5	315	15	Gram	gram	NN
cord-344093-3bniy5b5	315	16	-	-	HYPH
cord-344093-3bniy5b5	315	17	positive	positive	JJ
cord-344093-3bniy5b5	315	18	bacteria	bacteria	NNS
cord-344093-3bniy5b5	315	19	that	that	WDT
cord-344093-3bniy5b5	315	20	aggravates	aggravate	VBZ
cord-344093-3bniy5b5	315	21	the	the	DT
cord-344093-3bniy5b5	315	22	course	course	NN
cord-344093-3bniy5b5	315	23	of	of	IN
cord-344093-3bniy5b5	315	24	illness	illness	NN
cord-344093-3bniy5b5	315	25	.	.	.
cord-344093-3bniy5b5	316	1	This	this	DT
cord-344093-3bniy5b5	316	2	is	be	VBZ
cord-344093-3bniy5b5	316	3	well	well	RB
cord-344093-3bniy5b5	316	4	documented	document	VBN
cord-344093-3bniy5b5	316	5	for	for	IN
cord-344093-3bniy5b5	316	6	IAV	IAV	NNP
cord-344093-3bniy5b5	316	7	,	,	,
cord-344093-3bniy5b5	316	8	where	where	WRB
cord-344093-3bniy5b5	316	9	"	"	``
cord-344093-3bniy5b5	316	10	super	super	JJ
cord-344093-3bniy5b5	316	11	"	"	''
cord-344093-3bniy5b5	316	12	infections	infection	NNS
cord-344093-3bniy5b5	316	13	with	with	IN
cord-344093-3bniy5b5	316	14	Streptococcus	streptococcus	NN
cord-344093-3bniy5b5	316	15	pneumoniae	pneumoniae	NN
cord-344093-3bniy5b5	316	16	and	and	CC
cord-344093-3bniy5b5	316	17	Staphylococcus	Staphylococcus	NNP
cord-344093-3bniy5b5	316	18	aureus	aureu	NNS
cord-344093-3bniy5b5	316	19	are	be	VBP
cord-344093-3bniy5b5	316	20	the	the	DT
cord-344093-3bniy5b5	316	21	most	most	RBS
cord-344093-3bniy5b5	316	22	frequent	frequent	JJ
cord-344093-3bniy5b5	316	23	and	and	CC
cord-344093-3bniy5b5	316	24	increase	increase	VB
cord-344093-3bniy5b5	316	25	viral	viral	JJ
cord-344093-3bniy5b5	316	26	pneumonia	pneumonia	NN
cord-344093-3bniy5b5	316	27	-	-	HYPH
cord-344093-3bniy5b5	316	28	associated	associate	VBN
cord-344093-3bniy5b5	316	29	morbidity	morbidity	NN
cord-344093-3bniy5b5	316	30	and	and	CC
cord-344093-3bniy5b5	316	31	mortality	mortality	NN
cord-344093-3bniy5b5	316	32	(	(	-LRB-
cord-344093-3bniy5b5	316	33	181	181	CD
cord-344093-3bniy5b5	316	34	)	)	-RRB-
cord-344093-3bniy5b5	316	35	.	.	.
cord-344093-3bniy5b5	317	1	During	during	IN
cord-344093-3bniy5b5	317	2	the	the	DT
cord-344093-3bniy5b5	317	3	1918	1918	CD
cord-344093-3bniy5b5	317	4	IAV	IAV	NNP
cord-344093-3bniy5b5	317	5	pandemic	pandemic	NN
cord-344093-3bniy5b5	317	6	,	,	,
cord-344093-3bniy5b5	317	7	bacterial	bacterial	JJ
cord-344093-3bniy5b5	317	8	pneumonia	pneumonia	NN
cord-344093-3bniy5b5	317	9	was	be	VBD
cord-344093-3bniy5b5	317	10	evident	evident	JJ
cord-344093-3bniy5b5	317	11	in	in	IN
cord-344093-3bniy5b5	317	12	most	most	JJS
cord-344093-3bniy5b5	317	13	cases	case	NNS
cord-344093-3bniy5b5	317	14	(	(	-LRB-
cord-344093-3bniy5b5	317	15	182	182	CD
cord-344093-3bniy5b5	317	16	)	)	-RRB-
cord-344093-3bniy5b5	317	17	and	and	CC
cord-344093-3bniy5b5	317	18	also	also	RB
cord-344093-3bniy5b5	317	19	during	during	IN
cord-344093-3bniy5b5	317	20	the	the	DT
cord-344093-3bniy5b5	317	21	recent	recent	JJ
cord-344093-3bniy5b5	317	22	2009	2009	CD
cord-344093-3bniy5b5	317	23	H1N1	H1N1	NNP
cord-344093-3bniy5b5	317	24	pandemic	pandemic	NN
cord-344093-3bniy5b5	317	25	,	,	,
cord-344093-3bniy5b5	317	26	coinfections	coinfection	NNS
cord-344093-3bniy5b5	317	27	were	be	VBD
cord-344093-3bniy5b5	317	28	a	a	DT
cord-344093-3bniy5b5	317	29	relevant	relevant	JJ
cord-344093-3bniy5b5	317	30	factor	factor	NN
cord-344093-3bniy5b5	317	31	for	for	IN
cord-344093-3bniy5b5	317	32	severe	severe	JJ
cord-344093-3bniy5b5	317	33	disease	disease	NN
cord-344093-3bniy5b5	317	34	in	in	IN
cord-344093-3bniy5b5	317	35	a	a	DT
cord-344093-3bniy5b5	317	36	young	young	JJ
cord-344093-3bniy5b5	317	37	patient	patient	JJ
cord-344093-3bniy5b5	317	38	population	population	NN
cord-344093-3bniy5b5	317	39	without	without	IN
cord-344093-3bniy5b5	317	40	comorbidities	comorbiditie	NNS
cord-344093-3bniy5b5	317	41	(	(	-LRB-
cord-344093-3bniy5b5	317	42	183	183	CD
cord-344093-3bniy5b5	317	43	)	)	-RRB-
cord-344093-3bniy5b5	317	44	.	.	.
cord-344093-3bniy5b5	318	1	Interestingly	interestingly	RB
cord-344093-3bniy5b5	318	2	,	,	,
cord-344093-3bniy5b5	318	3	virus	virus	NN
cord-344093-3bniy5b5	318	4	-	-	HYPH
cord-344093-3bniy5b5	318	5	induced	induce	VBN
cord-344093-3bniy5b5	318	6	elevation	elevation	NN
cord-344093-3bniy5b5	318	7	of	of	IN
cord-344093-3bniy5b5	318	8	the	the	DT
cord-344093-3bniy5b5	318	9	type	type	NN
cord-344093-3bniy5b5	318	10	I	-PRON-	PRP
cord-344093-3bniy5b5	318	11	IFN	IFN	NNP
cord-344093-3bniy5b5	318	12	response	response	NN
cord-344093-3bniy5b5	318	13	levels	level	NNS
cord-344093-3bniy5b5	318	14	might	may	MD
cord-344093-3bniy5b5	318	15	promote	promote	VB
cord-344093-3bniy5b5	318	16	secondary	secondary	JJ
cord-344093-3bniy5b5	318	17	bacterial	bacterial	JJ
cord-344093-3bniy5b5	318	18	outgrowth	outgrowth	NN
cord-344093-3bniy5b5	318	19	by	by	IN
cord-344093-3bniy5b5	318	20	several	several	JJ
cord-344093-3bniy5b5	318	21	mechanisms	mechanism	NNS
cord-344093-3bniy5b5	318	22	[	[	-LRB-
cord-344093-3bniy5b5	318	23	reviewed	review	VBN
cord-344093-3bniy5b5	318	24	in	in	IN
cord-344093-3bniy5b5	318	25	Ref	Ref	NNP
cord-344093-3bniy5b5	318	26	.	.	.
cord-344093-3bniy5b5	319	1	(	(	-LRB-
cord-344093-3bniy5b5	319	2	184	184	CD
cord-344093-3bniy5b5	319	3	)	)	-RRB-
cord-344093-3bniy5b5	319	4	]	]	-RRB-
cord-344093-3bniy5b5	319	5	.	.	.
cord-344093-3bniy5b5	320	1	In	in	IN
cord-344093-3bniy5b5	320	2	line	line	NN
cord-344093-3bniy5b5	320	3	,	,	,
cord-344093-3bniy5b5	320	4	it	-PRON-	PRP
cord-344093-3bniy5b5	320	5	has	have	VBZ
cord-344093-3bniy5b5	320	6	been	be	VBN
cord-344093-3bniy5b5	320	7	repeatedly	repeatedly	RB
cord-344093-3bniy5b5	320	8	demonstrated	demonstrate	VBN
cord-344093-3bniy5b5	320	9	that	that	IN
cord-344093-3bniy5b5	320	10	lack	lack	NN
cord-344093-3bniy5b5	320	11	of	of	IN
cord-344093-3bniy5b5	320	12	type	type	NN
cord-344093-3bniy5b5	320	13	I	-PRON-	PRP
cord-344093-3bniy5b5	320	14	IFN	IFN	NNP
cord-344093-3bniy5b5	320	15	signaling	signal	VBG
cord-344093-3bniy5b5	320	16	results	result	NNS
cord-344093-3bniy5b5	320	17	in	in	IN
cord-344093-3bniy5b5	320	18	better	well	JJR
cord-344093-3bniy5b5	320	19	bacterial	bacterial	JJ
cord-344093-3bniy5b5	320	20	clearance	clearance	NN
cord-344093-3bniy5b5	320	21	and	and	CC
cord-344093-3bniy5b5	320	22	increased	increase	VBN
cord-344093-3bniy5b5	320	23	survival	survival	NN
cord-344093-3bniy5b5	320	24	rates	rate	NNS
cord-344093-3bniy5b5	320	25	in	in	IN
cord-344093-3bniy5b5	320	26	IAV	IAV	NNP
cord-344093-3bniy5b5	320	27	-	-	,
cord-344093-3bniy5b5	320	28	and	and	CC
cord-344093-3bniy5b5	320	29	S.	S.	NNP
cord-344093-3bniy5b5	320	30	pneumoniae	pneumoniae	NN
cord-344093-3bniy5b5	320	31	-	-	HYPH
cord-344093-3bniy5b5	320	32	superinfected	superinfect	VBN
cord-344093-3bniy5b5	320	33	mice	mouse	NNS
cord-344093-3bniy5b5	320	34	(	(	-LRB-
cord-344093-3bniy5b5	320	35	185	185	CD
cord-344093-3bniy5b5	320	36	)	)	-RRB-
cord-344093-3bniy5b5	320	37	(	(	-LRB-
cord-344093-3bniy5b5	320	38	186	186	CD
cord-344093-3bniy5b5	320	39	)	)	-RRB-
cord-344093-3bniy5b5	320	40	(	(	-LRB-
cord-344093-3bniy5b5	320	41	187	187	CD
cord-344093-3bniy5b5	320	42	)	)	-RRB-
cord-344093-3bniy5b5	320	43	.	.	.
cord-344093-3bniy5b5	321	1	Herein	herein	RB
cord-344093-3bniy5b5	321	2	,	,	,
cord-344093-3bniy5b5	321	3	IFN	IFN	NNP
cord-344093-3bniy5b5	321	4	-	-	HYPH
cord-344093-3bniy5b5	321	5	induced	induce	VBN
cord-344093-3bniy5b5	321	6	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	321	7	induction	induction	NN
cord-344093-3bniy5b5	321	8	as	as	RB
cord-344093-3bniy5b5	321	9	well	well	RB
cord-344093-3bniy5b5	321	10	as	as	IN
cord-344093-3bniy5b5	321	11	depletion	depletion	NN
cord-344093-3bniy5b5	321	12	or	or	CC
cord-344093-3bniy5b5	321	13	impaired	impaired	JJ
cord-344093-3bniy5b5	321	14	recruitment	recruitment	NN
cord-344093-3bniy5b5	321	15	of	of	IN
cord-344093-3bniy5b5	321	16	lymphocyte	lymphocyte	NN
cord-344093-3bniy5b5	321	17	subsets	subset	NNS
cord-344093-3bniy5b5	321	18	necessary	necessary	JJ
cord-344093-3bniy5b5	321	19	for	for	IN
cord-344093-3bniy5b5	321	20	bacterial	bacterial	JJ
cord-344093-3bniy5b5	321	21	control	control	NN
cord-344093-3bniy5b5	321	22	play	play	VBP
cord-344093-3bniy5b5	321	23	a	a	DT
cord-344093-3bniy5b5	321	24	critical	critical	JJ
cord-344093-3bniy5b5	321	25	role	role	NN
cord-344093-3bniy5b5	321	26	(	(	-LRB-
cord-344093-3bniy5b5	321	27	188	188	CD
cord-344093-3bniy5b5	321	28	,	,	,
cord-344093-3bniy5b5	321	29	189	189	CD
cord-344093-3bniy5b5	321	30	)	)	-RRB-
cord-344093-3bniy5b5	321	31	.	.	.
cord-344093-3bniy5b5	322	1	Bacterial	bacterial	JJ
cord-344093-3bniy5b5	322	2	clearance	clearance	NN
cord-344093-3bniy5b5	322	3	from	from	IN
cord-344093-3bniy5b5	322	4	the	the	DT
cord-344093-3bniy5b5	322	5	lung	lung	NN
cord-344093-3bniy5b5	322	6	has	have	VBZ
cord-344093-3bniy5b5	322	7	been	be	VBN
cord-344093-3bniy5b5	322	8	reported	report	VBN
cord-344093-3bniy5b5	322	9	to	to	TO
cord-344093-3bniy5b5	322	10	rely	rely	VB
cord-344093-3bniy5b5	322	11	on	on	IN
cord-344093-3bniy5b5	322	12	sufficient	sufficient	JJ
cord-344093-3bniy5b5	322	13	phagocyte	phagocyte	NNP
cord-344093-3bniy5b5	322	14	generation	generation	NN
cord-344093-3bniy5b5	322	15	,	,	,
cord-344093-3bniy5b5	322	16	recruitment	recruitment	NN
cord-344093-3bniy5b5	322	17	,	,	,
cord-344093-3bniy5b5	322	18	and	and	CC
cord-344093-3bniy5b5	322	19	survival	survival	NN
cord-344093-3bniy5b5	322	20	.	.	.
cord-344093-3bniy5b5	323	1	Type	type	NN
cord-344093-3bniy5b5	324	1	I	-PRON-	PRP
cord-344093-3bniy5b5	324	2	IFN	IFN	NNP
cord-344093-3bniy5b5	324	3	has	have	VBZ
cord-344093-3bniy5b5	324	4	been	be	VBN
cord-344093-3bniy5b5	324	5	demonstrated	demonstrate	VBN
cord-344093-3bniy5b5	324	6	to	to	TO
cord-344093-3bniy5b5	324	7	cause	cause	VB
cord-344093-3bniy5b5	324	8	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	324	9	in	in	IN
cord-344093-3bniy5b5	324	10	bone	bone	NN
cord-344093-3bniy5b5	324	11	marrow	marrow	NN
cord-344093-3bniy5b5	324	12	-	-	HYPH
cord-344093-3bniy5b5	324	13	derived	derive	VBN
cord-344093-3bniy5b5	324	14	granulocytes	granulocyte	NNS
cord-344093-3bniy5b5	324	15	,	,	,
cord-344093-3bniy5b5	324	16	affecting	affect	VBG
cord-344093-3bniy5b5	324	17	the	the	DT
cord-344093-3bniy5b5	324	18	numbers	number	NNS
cord-344093-3bniy5b5	324	19	of	of	IN
cord-344093-3bniy5b5	324	20	recruited	recruit	VBN
cord-344093-3bniy5b5	324	21	neutrophils	neutrophil	NNS
cord-344093-3bniy5b5	324	22	(	(	-LRB-
cord-344093-3bniy5b5	324	23	189	189	CD
cord-344093-3bniy5b5	324	24	)	)	-RRB-
cord-344093-3bniy5b5	324	25	,	,	,
cord-344093-3bniy5b5	324	26	but	but	CC
cord-344093-3bniy5b5	324	27	also	also	RB
cord-344093-3bniy5b5	324	28	to	to	TO
cord-344093-3bniy5b5	324	29	impair	impair	VB
cord-344093-3bniy5b5	324	30	expression	expression	NN
cord-344093-3bniy5b5	324	31	of	of	IN
cord-344093-3bniy5b5	324	32	the	the	DT
cord-344093-3bniy5b5	324	33	cytokines	cytokine	NNS
cord-344093-3bniy5b5	324	34	CXCL1	CXCL1	NNP
cord-344093-3bniy5b5	324	35	(	(	-LRB-
cord-344093-3bniy5b5	324	36	or	or	CC
cord-344093-3bniy5b5	324	37	KC	KC	NNP
cord-344093-3bniy5b5	324	38	)	)	-RRB-
cord-344093-3bniy5b5	324	39	and	and	CC
cord-344093-3bniy5b5	324	40	CXCL2	CXCL2	NNP
cord-344093-3bniy5b5	324	41	(	(	-LRB-
cord-344093-3bniy5b5	324	42	or	or	CC
cord-344093-3bniy5b5	324	43	MIP-2	MIP-2	NNP
cord-344093-3bniy5b5	324	44	)	)	-RRB-
cord-344093-3bniy5b5	324	45	,	,	,
cord-344093-3bniy5b5	324	46	thus	thus	RB
cord-344093-3bniy5b5	324	47	inhibiting	inhibit	VBG
cord-344093-3bniy5b5	324	48	neutrophil	neutrophil	NN
cord-344093-3bniy5b5	324	49	recruitment	recruitment	NN
cord-344093-3bniy5b5	324	50	to	to	IN
cord-344093-3bniy5b5	324	51	the	the	DT
cord-344093-3bniy5b5	324	52	lungs	lung	NNS
cord-344093-3bniy5b5	324	53	with	with	IN
cord-344093-3bniy5b5	324	54	severe	severe	JJ
cord-344093-3bniy5b5	324	55	effects	effect	NNS
cord-344093-3bniy5b5	324	56	on	on	IN
cord-344093-3bniy5b5	324	57	survival	survival	NN
cord-344093-3bniy5b5	324	58	of	of	IN
cord-344093-3bniy5b5	324	59	superinfected	superinfect	VBN
cord-344093-3bniy5b5	324	60	mice	mouse	NNS
cord-344093-3bniy5b5	324	61	(	(	-LRB-
cord-344093-3bniy5b5	324	62	185	185	CD
cord-344093-3bniy5b5	324	63	)	)	-RRB-
cord-344093-3bniy5b5	324	64	.	.	.
cord-344093-3bniy5b5	325	1	A	a	DT
cord-344093-3bniy5b5	325	2	recent	recent	JJ
cord-344093-3bniy5b5	325	3	report	report	NN
cord-344093-3bniy5b5	325	4	by	by	IN
cord-344093-3bniy5b5	325	5	Schliehe	Schliehe	NNP
cord-344093-3bniy5b5	325	6	et	et	NNP
cord-344093-3bniy5b5	325	7	al	al	NNP
cord-344093-3bniy5b5	325	8	.	.	.
cord-344093-3bniy5b5	326	1	(	(	-LRB-
cord-344093-3bniy5b5	326	2	190	190	CD
cord-344093-3bniy5b5	326	3	)	)	-RRB-
cord-344093-3bniy5b5	326	4	elucidated	elucidate	VBD
cord-344093-3bniy5b5	326	5	the	the	DT
cord-344093-3bniy5b5	326	6	mechanistic	mechanistic	JJ
cord-344093-3bniy5b5	326	7	background	background	NN
cord-344093-3bniy5b5	326	8	for	for	IN
cord-344093-3bniy5b5	326	9	impaired	impaired	JJ
cord-344093-3bniy5b5	326	10	CXCL1	CXCL1	NNP
cord-344093-3bniy5b5	326	11	expression	expression	NN
cord-344093-3bniy5b5	326	12	and	and	CC
cord-344093-3bniy5b5	326	13	secretion	secretion	NN
cord-344093-3bniy5b5	326	14	and	and	CC
cord-344093-3bniy5b5	326	15	demonstrated	demonstrate	VBD
cord-344093-3bniy5b5	326	16	that	that	DT
cord-344093-3bniy5b5	326	17	type	type	NN
cord-344093-3bniy5b5	326	18	I	-PRON-	PRP
cord-344093-3bniy5b5	326	19	IFNs	ifn	NNS
cord-344093-3bniy5b5	326	20	activate	activate	VBP
cord-344093-3bniy5b5	326	21	the	the	DT
cord-344093-3bniy5b5	326	22	histone	histone	NN
cord-344093-3bniy5b5	326	23	methyltransferase	methyltransferase	NN
cord-344093-3bniy5b5	326	24	Setdb2	Setdb2	NNP
cord-344093-3bniy5b5	326	25	,	,	,
cord-344093-3bniy5b5	326	26	which	which	WDT
cord-344093-3bniy5b5	326	27	in	in	IN
cord-344093-3bniy5b5	326	28	turn	turn	NN
cord-344093-3bniy5b5	326	29	represses	repress	VBZ
cord-344093-3bniy5b5	326	30	the	the	DT
cord-344093-3bniy5b5	326	31	Cxcl1	cxcl1	JJ
cord-344093-3bniy5b5	326	32	promoter	promoter	NN
cord-344093-3bniy5b5	326	33	and	and	CC
cord-344093-3bniy5b5	326	34	thus	thus	RB
cord-344093-3bniy5b5	326	35	impairs	impair	VBZ
cord-344093-3bniy5b5	326	36	neutrophil	neutrophil	NN
cord-344093-3bniy5b5	326	37	recruitment	recruitment	NN
cord-344093-3bniy5b5	326	38	and	and	CC
cord-344093-3bniy5b5	326	39	bacterial	bacterial	JJ
cord-344093-3bniy5b5	326	40	clearance	clearance	NN
cord-344093-3bniy5b5	326	41	.	.	.
cord-344093-3bniy5b5	327	1	Moreover	moreover	RB
cord-344093-3bniy5b5	327	2	,	,	,
cord-344093-3bniy5b5	327	3	type	type	NN
cord-344093-3bniy5b5	327	4	I	-PRON-	PRP
cord-344093-3bniy5b5	327	5	IFN	IFN	NNP
cord-344093-3bniy5b5	327	6	production	production	NN
cord-344093-3bniy5b5	327	7	decreases	decrease	VBZ
cord-344093-3bniy5b5	327	8	CCL2	CCL2	NNP
cord-344093-3bniy5b5	327	9	production	production	NN
cord-344093-3bniy5b5	327	10	,	,	,
cord-344093-3bniy5b5	327	11	thus	thus	RB
cord-344093-3bniy5b5	327	12	inhibiting	inhibit	VBG
cord-344093-3bniy5b5	327	13	macrophage	macrophage	NN
cord-344093-3bniy5b5	327	14	recruitment	recruitment	NN
cord-344093-3bniy5b5	327	15	,	,	,
cord-344093-3bniy5b5	327	16	which	which	WDT
cord-344093-3bniy5b5	327	17	as	as	RB
cord-344093-3bniy5b5	327	18	well	well	RB
cord-344093-3bniy5b5	327	19	has	have	VBZ
cord-344093-3bniy5b5	327	20	been	be	VBN
cord-344093-3bniy5b5	327	21	reported	report	VBN
cord-344093-3bniy5b5	327	22	to	to	TO
cord-344093-3bniy5b5	327	23	have	have	VB
cord-344093-3bniy5b5	327	24	detrimental	detrimental	JJ
cord-344093-3bniy5b5	327	25	effects	effect	NNS
cord-344093-3bniy5b5	327	26	on	on	IN
cord-344093-3bniy5b5	327	27	bacterial	bacterial	JJ
cord-344093-3bniy5b5	327	28	clearance	clearance	NN
cord-344093-3bniy5b5	327	29	and	and	CC
cord-344093-3bniy5b5	327	30	disease	disease	NN
cord-344093-3bniy5b5	327	31	progression	progression	NN
cord-344093-3bniy5b5	327	32	in	in	IN
cord-344093-3bniy5b5	327	33	bacterial	bacterial	JJ
cord-344093-3bniy5b5	327	34	superinfection	superinfection	NN
cord-344093-3bniy5b5	327	35	after	after	IN
cord-344093-3bniy5b5	327	36	viral	viral	JJ
cord-344093-3bniy5b5	327	37	insult	insult	NN
cord-344093-3bniy5b5	327	38	in	in	IN
cord-344093-3bniy5b5	327	39	vivo	vivo	NNP
cord-344093-3bniy5b5	327	40	(	(	-LRB-
cord-344093-3bniy5b5	327	41	186	186	CD
cord-344093-3bniy5b5	327	42	)	)	-RRB-
cord-344093-3bniy5b5	327	43	.	.	.
cord-344093-3bniy5b5	328	1	In	in	IN
cord-344093-3bniy5b5	328	2	addition	addition	NN
cord-344093-3bniy5b5	328	3	,	,	,
cord-344093-3bniy5b5	328	4	type	type	NN
cord-344093-3bniy5b5	328	5	I	-PRON-	PRP
cord-344093-3bniy5b5	328	6	IFNs	ifns	VBP
cord-344093-3bniy5b5	328	7	also	also	RB
cord-344093-3bniy5b5	328	8	impair	impair	VBP
cord-344093-3bniy5b5	328	9	γδ	γδ	IN
cord-344093-3bniy5b5	328	10	T	t	NN
cord-344093-3bniy5b5	328	11	cell	cell	NN
cord-344093-3bniy5b5	328	12	function	function	NN
cord-344093-3bniy5b5	328	13	and	and	CC
cord-344093-3bniy5b5	328	14	IL-17	IL-17	NNP
cord-344093-3bniy5b5	328	15	release	release	NN
cord-344093-3bniy5b5	328	16	,	,	,
cord-344093-3bniy5b5	328	17	which	which	WDT
cord-344093-3bniy5b5	328	18	was	be	VBD
cord-344093-3bniy5b5	328	19	shown	show	VBN
cord-344093-3bniy5b5	328	20	to	to	TO
cord-344093-3bniy5b5	328	21	increase	increase	VB
cord-344093-3bniy5b5	328	22	susceptibility	susceptibility	NN
cord-344093-3bniy5b5	328	23	to	to	IN
cord-344093-3bniy5b5	328	24	S.	S.	NNP
cord-344093-3bniy5b5	328	25	pneumoniae	pneumoniae	NN
cord-344093-3bniy5b5	328	26	superinfection	superinfection	NN
cord-344093-3bniy5b5	328	27	after	after	IN
cord-344093-3bniy5b5	328	28	IAV	IAV	NNP
cord-344093-3bniy5b5	328	29	challenge	challenge	NN
cord-344093-3bniy5b5	328	30	(	(	-LRB-
cord-344093-3bniy5b5	328	31	187	187	CD
cord-344093-3bniy5b5	328	32	)	)	-RRB-
cord-344093-3bniy5b5	328	33	.	.	.
cord-344093-3bniy5b5	329	1	Also	also	RB
cord-344093-3bniy5b5	329	2	in	in	IN
cord-344093-3bniy5b5	329	3	S.	S.	NNP
cord-344093-3bniy5b5	329	4	aureus	aureus	NN
cord-344093-3bniy5b5	329	5	pneumonia	pneumonia	NN
cord-344093-3bniy5b5	329	6	,	,	,
cord-344093-3bniy5b5	329	7	a	a	DT
cord-344093-3bniy5b5	329	8	robust	robust	JJ
cord-344093-3bniy5b5	329	9	type	type	NN
cord-344093-3bniy5b5	329	10	I	-PRON-	PRP
cord-344093-3bniy5b5	329	11	IFN	IFN	NNP
cord-344093-3bniy5b5	329	12	response	response	NN
cord-344093-3bniy5b5	329	13	is	be	VBZ
cord-344093-3bniy5b5	329	14	correlated	correlate	VBN
cord-344093-3bniy5b5	329	15	to	to	IN
cord-344093-3bniy5b5	329	16	excessive	excessive	JJ
cord-344093-3bniy5b5	329	17	morbidity	morbidity	NN
cord-344093-3bniy5b5	329	18	and	and	CC
cord-344093-3bniy5b5	329	19	tissue	tissue	NN
cord-344093-3bniy5b5	329	20	injury	injury	NN
cord-344093-3bniy5b5	329	21	(	(	-LRB-
cord-344093-3bniy5b5	329	22	191	191	CD
cord-344093-3bniy5b5	329	23	)	)	-RRB-
cord-344093-3bniy5b5	329	24	.	.	.
cord-344093-3bniy5b5	330	1	In	in	IN
cord-344093-3bniy5b5	330	2	a	a	DT
cord-344093-3bniy5b5	330	3	model	model	NN
cord-344093-3bniy5b5	330	4	of	of	IN
cord-344093-3bniy5b5	330	5	polyI	polyI	NNP
cord-344093-3bniy5b5	330	6	:	:	:
cord-344093-3bniy5b5	330	7	C	C	NNP
cord-344093-3bniy5b5	330	8	,	,	,
cord-344093-3bniy5b5	330	9	S.	S.	NNP
cord-344093-3bniy5b5	330	10	aureus	aureus	NN
cord-344093-3bniy5b5	330	11	(	(	-LRB-
cord-344093-3bniy5b5	330	12	methicillinresistant	methicillinresistant	JJ
cord-344093-3bniy5b5	330	13	strain	strain	NN
cord-344093-3bniy5b5	330	14	,	,	,
cord-344093-3bniy5b5	330	15	MRSA	MRSA	NNP
cord-344093-3bniy5b5	330	16	)	)	-RRB-
cord-344093-3bniy5b5	330	17	superinfection	superinfection	NN
cord-344093-3bniy5b5	330	18	,	,	,
cord-344093-3bniy5b5	330	19	polyI	polyI	NNP
cord-344093-3bniy5b5	330	20	:	:	:
cord-344093-3bniy5b5	330	21	C	c	NN
cord-344093-3bniy5b5	330	22	treatment	treatment	NN
cord-344093-3bniy5b5	330	23	prior	prior	RB
cord-344093-3bniy5b5	330	24	to	to	IN
cord-344093-3bniy5b5	330	25	bacterial	bacterial	JJ
cord-344093-3bniy5b5	330	26	infection	infection	NN
cord-344093-3bniy5b5	330	27	enhanced	enhance	VBN
cord-344093-3bniy5b5	330	28	type	type	NN
cord-344093-3bniy5b5	331	1	I	-PRON-	PRP
cord-344093-3bniy5b5	331	2	IFN	IFN	NNP
cord-344093-3bniy5b5	331	3	levels	level	NNS
cord-344093-3bniy5b5	331	4	and	and	CC
cord-344093-3bniy5b5	331	5	decreased	decrease	VBD
cord-344093-3bniy5b5	331	6	bacterial	bacterial	JJ
cord-344093-3bniy5b5	331	7	clearance	clearance	NN
cord-344093-3bniy5b5	331	8	and	and	CC
cord-344093-3bniy5b5	331	9	survival	survival	NN
cord-344093-3bniy5b5	331	10	(	(	-LRB-
cord-344093-3bniy5b5	331	11	192	192	CD
cord-344093-3bniy5b5	331	12	)	)	-RRB-
cord-344093-3bniy5b5	331	13	.	.	.
cord-344093-3bniy5b5	332	1	Furthermore	furthermore	RB
cord-344093-3bniy5b5	332	2	,	,	,
cord-344093-3bniy5b5	332	3	Shepardson	Shepardson	NNP
cord-344093-3bniy5b5	332	4	et	et	NNP
cord-344093-3bniy5b5	332	5	al	al	NNP
cord-344093-3bniy5b5	332	6	.	.	.
cord-344093-3bniy5b5	333	1	(	(	-LRB-
cord-344093-3bniy5b5	333	2	193	193	CD
cord-344093-3bniy5b5	333	3	)	)	-RRB-
cord-344093-3bniy5b5	333	4	demonstrated	demonstrate	VBD
cord-344093-3bniy5b5	333	5	that	that	IN
cord-344093-3bniy5b5	333	6	late	late	JJ
cord-344093-3bniy5b5	333	7	type	type	NN
cord-344093-3bniy5b5	333	8	I	-PRON-	PRP
cord-344093-3bniy5b5	333	9	IFN	IFN	NNP
cord-344093-3bniy5b5	333	10	induction	induction	NN
cord-344093-3bniy5b5	333	11	rendered	render	VBD
cord-344093-3bniy5b5	333	12	mice	mouse	NNS
cord-344093-3bniy5b5	333	13	more	more	RBR
cord-344093-3bniy5b5	333	14	susceptible	susceptible	JJ
cord-344093-3bniy5b5	333	15	to	to	IN
cord-344093-3bniy5b5	333	16	secondary	secondary	JJ
cord-344093-3bniy5b5	333	17	bacterial	bacterial	JJ
cord-344093-3bniy5b5	333	18	pneumonia	pneumonia	NN
cord-344093-3bniy5b5	333	19	in	in	IN
cord-344093-3bniy5b5	333	20	a	a	DT
cord-344093-3bniy5b5	333	21	model	model	NN
cord-344093-3bniy5b5	333	22	of	of	IN
cord-344093-3bniy5b5	333	23	IAV	IAV	NNP
cord-344093-3bniy5b5	333	24	-	-	HYPH
cord-344093-3bniy5b5	333	25	MRSA	MRSA	NNP
cord-344093-3bniy5b5	333	26	superinfection	superinfection	NN
cord-344093-3bniy5b5	333	27	.	.	.
cord-344093-3bniy5b5	334	1	Only	only	RB
cord-344093-3bniy5b5	334	2	limited	limited	JJ
cord-344093-3bniy5b5	334	3	data	datum	NNS
cord-344093-3bniy5b5	334	4	are	be	VBP
cord-344093-3bniy5b5	334	5	available	available	JJ
cord-344093-3bniy5b5	334	6	on	on	IN
cord-344093-3bniy5b5	334	7	a	a	DT
cord-344093-3bniy5b5	334	8	direct	direct	JJ
cord-344093-3bniy5b5	334	9	role	role	NN
cord-344093-3bniy5b5	334	10	of	of	IN
cord-344093-3bniy5b5	334	11	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	334	12	in	in	IN
cord-344093-3bniy5b5	334	13	respiratory	respiratory	JJ
cord-344093-3bniy5b5	334	14	disease	disease	NN
cord-344093-3bniy5b5	334	15	progression	progression	NN
cord-344093-3bniy5b5	334	16	due	due	IN
cord-344093-3bniy5b5	334	17	to	to	IN
cord-344093-3bniy5b5	334	18	bacterial	bacterial	JJ
cord-344093-3bniy5b5	334	19	superinfections	superinfection	NNS
cord-344093-3bniy5b5	334	20	.	.	.
cord-344093-3bniy5b5	335	1	In	in	IN
cord-344093-3bniy5b5	335	2	a	a	DT
cord-344093-3bniy5b5	335	3	model	model	NN
cord-344093-3bniy5b5	335	4	of	of	IN
cord-344093-3bniy5b5	335	5	IAV	IAV	NNP
cord-344093-3bniy5b5	335	6	-	-	HYPH
cord-344093-3bniy5b5	335	7	Haemophilus	Haemophilus	NNP
cord-344093-3bniy5b5	335	8	influenza	influenza	NN
cord-344093-3bniy5b5	335	9	infection	infection	NN
cord-344093-3bniy5b5	335	10	,	,	,
cord-344093-3bniy5b5	335	11	neither	neither	DT
cord-344093-3bniy5b5	335	12	deficiency	deficiency	NN
cord-344093-3bniy5b5	335	13	for	for	IN
cord-344093-3bniy5b5	335	14	CC	cc	NN
cord-344093-3bniy5b5	335	15	chemokine	chemokine	NN
cord-344093-3bniy5b5	335	16	receptor	receptor	NN
cord-344093-3bniy5b5	335	17	type	type	NN
cord-344093-3bniy5b5	335	18	2	2	CD
cord-344093-3bniy5b5	335	19	,	,	,
cord-344093-3bniy5b5	335	20	inhibiting	inhibit	VBG
cord-344093-3bniy5b5	335	21	bone	bone	NN
cord-344093-3bniy5b5	335	22	marrow	marrow	NN
cord-344093-3bniy5b5	335	23	-	-	HYPH
cord-344093-3bniy5b5	335	24	derived	derive	VBN
cord-344093-3bniy5b5	335	25	macrophage	macrophage	NN
cord-344093-3bniy5b5	335	26	recruitment	recruitment	NN
cord-344093-3bniy5b5	335	27	,	,	,
cord-344093-3bniy5b5	335	28	nor	nor	CC
cord-344093-3bniy5b5	335	29	deficiency	deficiency	NN
cord-344093-3bniy5b5	335	30	of	of	IN
cord-344093-3bniy5b5	335	31	Fas	Fas	NNP
cord-344093-3bniy5b5	335	32	or	or	CC
cord-344093-3bniy5b5	335	33	TNFR1	TNFR1	NNP
cord-344093-3bniy5b5	335	34	impacted	impact	VBD
cord-344093-3bniy5b5	335	35	outcome	outcome	NN
cord-344093-3bniy5b5	335	36	(	(	-LRB-
cord-344093-3bniy5b5	335	37	194	194	CD
cord-344093-3bniy5b5	335	38	)	)	-RRB-
cord-344093-3bniy5b5	335	39	.	.	.
cord-344093-3bniy5b5	336	1	Yet	yet	RB
cord-344093-3bniy5b5	336	2	,	,	,
cord-344093-3bniy5b5	336	3	during	during	IN
cord-344093-3bniy5b5	336	4	S.	S.	NNP
cord-344093-3bniy5b5	336	5	pneumoniae	pneumoniae	NN
cord-344093-3bniy5b5	336	6	single	single	JJ
cord-344093-3bniy5b5	336	7	infection	infection	NN
cord-344093-3bniy5b5	336	8	,	,	,
cord-344093-3bniy5b5	336	9	early	early	JJ
cord-344093-3bniy5b5	336	10	cell	cell	NN
cord-344093-3bniy5b5	336	11	death	death	NN
cord-344093-3bniy5b5	336	12	of	of	IN
cord-344093-3bniy5b5	336	13	macrophages	macrophage	NNS
cord-344093-3bniy5b5	336	14	is	be	VBZ
cord-344093-3bniy5b5	336	15	thought	think	VBN
cord-344093-3bniy5b5	336	16	to	to	TO
cord-344093-3bniy5b5	336	17	limit	limit	VB
cord-344093-3bniy5b5	336	18	an	an	DT
cord-344093-3bniy5b5	336	19	exuberant	exuberant	JJ
cord-344093-3bniy5b5	336	20	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	336	21	reaction	reaction	NN
cord-344093-3bniy5b5	336	22	and	and	CC
cord-344093-3bniy5b5	336	23	accordingly	accordingly	RB
cord-344093-3bniy5b5	336	24	,	,	,
cord-344093-3bniy5b5	336	25	a	a	DT
cord-344093-3bniy5b5	336	26	study	study	NN
cord-344093-3bniy5b5	336	27	by	by	IN
cord-344093-3bniy5b5	336	28	Steinwede	Steinwede	NNP
cord-344093-3bniy5b5	336	29	et	et	NNP
cord-344093-3bniy5b5	336	30	al	al	NNP
cord-344093-3bniy5b5	336	31	.	.	.
cord-344093-3bniy5b5	337	1	(	(	-LRB-
cord-344093-3bniy5b5	337	2	195	195	CD
cord-344093-3bniy5b5	337	3	)	)	-RRB-
cord-344093-3bniy5b5	337	4	revealed	reveal	VBD
cord-344093-3bniy5b5	337	5	that	that	IN
cord-344093-3bniy5b5	337	6	neutrophil	neutrophil	NN
cord-344093-3bniy5b5	337	7	-	-	HYPH
cord-344093-3bniy5b5	337	8	derived	derive	VBN
cord-344093-3bniy5b5	337	9	TRAIL	trail	NN
cord-344093-3bniy5b5	337	10	limits	limit	VBZ
cord-344093-3bniy5b5	337	11	tissue	tissue	NN
cord-344093-3bniy5b5	337	12	injury	injury	NN
cord-344093-3bniy5b5	337	13	by	by	IN
cord-344093-3bniy5b5	337	14	inducing	induce	VBG
cord-344093-3bniy5b5	337	15	cell	cell	NN
cord-344093-3bniy5b5	337	16	death	death	NN
cord-344093-3bniy5b5	337	17	in	in	IN
cord-344093-3bniy5b5	337	18	DR5-epressing	dr5-epresse	VBG
cord-344093-3bniy5b5	337	19	lung	lung	NN
cord-344093-3bniy5b5	337	20	macrophages	macrophage	NNS
cord-344093-3bniy5b5	337	21	in	in	IN
cord-344093-3bniy5b5	337	22	bacterial	bacterial	JJ
cord-344093-3bniy5b5	337	23	mono	mono	NN
cord-344093-3bniy5b5	337	24	-	-	HYPH
cord-344093-3bniy5b5	337	25	infection	infection	NN
cord-344093-3bniy5b5	337	26	(	(	-LRB-
cord-344093-3bniy5b5	337	27	195	195	CD
cord-344093-3bniy5b5	337	28	)	)	-RRB-
cord-344093-3bniy5b5	337	29	.	.	.
cord-344093-3bniy5b5	338	1	In	in	IN
cord-344093-3bniy5b5	338	2	contrast	contrast	NN
cord-344093-3bniy5b5	338	3	,	,	,
cord-344093-3bniy5b5	338	4	in	in	IN
cord-344093-3bniy5b5	338	5	the	the	DT
cord-344093-3bniy5b5	338	6	IAV	IAV	NNP
cord-344093-3bniy5b5	338	7	-	-	HYPH
cord-344093-3bniy5b5	338	8	S.	S.	NNP
cord-344093-3bniy5b5	338	9	pneumoniae	pneumoniae	NN
cord-344093-3bniy5b5	338	10	superinfection	superinfection	NN
cord-344093-3bniy5b5	338	11	mouse	mouse	NN
cord-344093-3bniy5b5	338	12	model	model	NN
cord-344093-3bniy5b5	338	13	,	,	,
cord-344093-3bniy5b5	338	14	IAVinduced	IAVinduced	NNP
cord-344093-3bniy5b5	338	15	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	338	16	has	have	VBZ
cord-344093-3bniy5b5	338	17	a	a	DT
cord-344093-3bniy5b5	338	18	detrimental	detrimental	JJ
cord-344093-3bniy5b5	338	19	effect	effect	NN
cord-344093-3bniy5b5	338	20	on	on	IN
cord-344093-3bniy5b5	338	21	overall	overall	JJ
cord-344093-3bniy5b5	338	22	mortality	mortality	NN
cord-344093-3bniy5b5	338	23	(	(	-LRB-
cord-344093-3bniy5b5	338	24	7	7	CD
cord-344093-3bniy5b5	338	25	)	)	-RRB-
cord-344093-3bniy5b5	338	26	,	,	,
cord-344093-3bniy5b5	338	27	as	as	IN
cord-344093-3bniy5b5	338	28	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	338	29	-	-	HYPH
cord-344093-3bniy5b5	338	30	induced	induce	VBN
cord-344093-3bniy5b5	338	31	epithelial	epithelial	JJ
cord-344093-3bniy5b5	338	32	injury	injury	NN
cord-344093-3bniy5b5	338	33	enhanced	enhance	VBN
cord-344093-3bniy5b5	338	34	bacterial	bacterial	JJ
cord-344093-3bniy5b5	338	35	outgrowth	outgrowth	NN
cord-344093-3bniy5b5	338	36	of	of	IN
cord-344093-3bniy5b5	338	37	S.	S.	NNP
cord-344093-3bniy5b5	338	38	pneumoniae	pneumoniae	NN
cord-344093-3bniy5b5	338	39	-	-	HYPH
cord-344093-3bniy5b5	338	40	administered	administer	VBN
cord-344093-3bniy5b5	338	41	at	at	IN
cord-344093-3bniy5b5	338	42	day	day	NN
cord-344093-3bniy5b5	338	43	5	5	CD
cord-344093-3bniy5b5	338	44	after	after	IN
cord-344093-3bniy5b5	338	45	IAV	IAV	NNP
cord-344093-3bniy5b5	338	46	infection	infection	NN
cord-344093-3bniy5b5	338	47	-	-	:
cord-344093-3bniy5b5	338	48	markedly	markedly	RB
cord-344093-3bniy5b5	338	49	.	.	.
cord-344093-3bniy5b5	339	1	Importantly	importantly	RB
cord-344093-3bniy5b5	339	2	,	,	,
cord-344093-3bniy5b5	339	3	administration	administration	NN
cord-344093-3bniy5b5	339	4	of	of	IN
cord-344093-3bniy5b5	339	5	anti	anti	NNP
cord-344093-3bniy5b5	339	6	-	-	JJ
cord-344093-3bniy5b5	339	7	TRAIL	trail	JJ
cord-344093-3bniy5b5	339	8	neutralizing	neutralize	VBG
cord-344093-3bniy5b5	339	9	antibodies	antibody	NNS
cord-344093-3bniy5b5	339	10	enhanced	enhance	VBN
cord-344093-3bniy5b5	339	11	bacterial	bacterial	JJ
cord-344093-3bniy5b5	339	12	control	control	NN
cord-344093-3bniy5b5	339	13	by	by	IN
cord-344093-3bniy5b5	339	14	the	the	DT
cord-344093-3bniy5b5	339	15	host	host	NN
cord-344093-3bniy5b5	339	16	organism	organism	NN
cord-344093-3bniy5b5	339	17	.	.	.
cord-344093-3bniy5b5	340	1	Thus	thus	RB
cord-344093-3bniy5b5	340	2	,	,	,
cord-344093-3bniy5b5	340	3	the	the	DT
cord-344093-3bniy5b5	340	4	activation	activation	NN
cord-344093-3bniy5b5	340	5	of	of	IN
cord-344093-3bniy5b5	340	6	IFN	IFN	NNP
cord-344093-3bniy5b5	340	7	/	/	SYM
cord-344093-3bniy5b5	340	8	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	340	9	-	-	HYPH
cord-344093-3bniy5b5	340	10	mediated	mediate	VBN
cord-344093-3bniy5b5	340	11	signaling	signaling	NN
cord-344093-3bniy5b5	340	12	in	in	IN
cord-344093-3bniy5b5	340	13	viral	viral	JJ
cord-344093-3bniy5b5	340	14	infection	infection	NN
cord-344093-3bniy5b5	340	15	has	have	VBZ
cord-344093-3bniy5b5	340	16	detrimental	detrimental	JJ
cord-344093-3bniy5b5	340	17	implication	implication	NN
cord-344093-3bniy5b5	340	18	for	for	IN
cord-344093-3bniy5b5	340	19	outcome	outcome	NN
cord-344093-3bniy5b5	340	20	of	of	IN
cord-344093-3bniy5b5	340	21	secondary	secondary	JJ
cord-344093-3bniy5b5	340	22	bacterial	bacterial	JJ
cord-344093-3bniy5b5	340	23	infection	infection	NN
cord-344093-3bniy5b5	340	24	following	follow	VBG
cord-344093-3bniy5b5	340	25	viral	viral	JJ
cord-344093-3bniy5b5	340	26	insult	insult	NN
cord-344093-3bniy5b5	340	27	,	,	,
cord-344093-3bniy5b5	340	28	rendering	render	VBG
cord-344093-3bniy5b5	340	29	the	the	DT
cord-344093-3bniy5b5	340	30	IFN	IFN	NNP
cord-344093-3bniy5b5	340	31	/	/	SYM
cord-344093-3bniy5b5	340	32	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	340	33	signaling	signal	VBG
cord-344093-3bniy5b5	340	34	axis	axis	NN
cord-344093-3bniy5b5	340	35	an	an	DT
cord-344093-3bniy5b5	340	36	interesting	interesting	JJ
cord-344093-3bniy5b5	340	37	therapeutic	therapeutic	JJ
cord-344093-3bniy5b5	340	38	target	target	NN
cord-344093-3bniy5b5	340	39	not	not	RB
cord-344093-3bniy5b5	340	40	only	only	RB
cord-344093-3bniy5b5	340	41	in	in	IN
cord-344093-3bniy5b5	340	42	respiratory	respiratory	JJ
cord-344093-3bniy5b5	340	43	viral	viral	JJ
cord-344093-3bniy5b5	340	44	infections	infection	NNS
cord-344093-3bniy5b5	340	45	but	but	CC
cord-344093-3bniy5b5	340	46	also	also	RB
cord-344093-3bniy5b5	340	47	in	in	IN
cord-344093-3bniy5b5	340	48	complicating	complicate	VBG
cord-344093-3bniy5b5	340	49	bacterial	bacterial	JJ
cord-344093-3bniy5b5	340	50	superinfection	superinfection	NN
cord-344093-3bniy5b5	340	51	.	.	.
cord-344093-3bniy5b5	341	1	An	an	DT
cord-344093-3bniy5b5	341	2	increasing	increase	VBG
cord-344093-3bniy5b5	341	3	number	number	NN
cord-344093-3bniy5b5	341	4	of	of	IN
cord-344093-3bniy5b5	341	5	reports	report	NNS
cord-344093-3bniy5b5	341	6	connect	connect	VBP
cord-344093-3bniy5b5	341	7	progression	progression	NN
cord-344093-3bniy5b5	341	8	of	of	IN
cord-344093-3bniy5b5	341	9	chronic	chronic	JJ
cord-344093-3bniy5b5	341	10	respiratory	respiratory	JJ
cord-344093-3bniy5b5	341	11	disease	disease	NN
cord-344093-3bniy5b5	341	12	to	to	IN
cord-344093-3bniy5b5	341	13	acute	acute	JJ
cord-344093-3bniy5b5	341	14	respiratory	respiratory	JJ
cord-344093-3bniy5b5	341	15	virus	virus	NN
cord-344093-3bniy5b5	341	16	infection	infection	NN
cord-344093-3bniy5b5	341	17	or	or	CC
cord-344093-3bniy5b5	341	18	proapoptotic	proapoptotic	JJ
cord-344093-3bniy5b5	341	19	signaling	signal	VBG
cord-344093-3bniy5b5	341	20	events	event	NNS
cord-344093-3bniy5b5	341	21	.	.	.
cord-344093-3bniy5b5	342	1	In	in	IN
cord-344093-3bniy5b5	342	2	fact	fact	NN
cord-344093-3bniy5b5	342	3	,	,	,
cord-344093-3bniy5b5	342	4	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	342	5	has	have	VBZ
cord-344093-3bniy5b5	342	6	been	be	VBN
cord-344093-3bniy5b5	342	7	reported	report	VBN
cord-344093-3bniy5b5	342	8	to	to	TO
cord-344093-3bniy5b5	342	9	be	be	VB
cord-344093-3bniy5b5	342	10	a	a	DT
cord-344093-3bniy5b5	342	11	critical	critical	JJ
cord-344093-3bniy5b5	342	12	determinant	determinant	NN
cord-344093-3bniy5b5	342	13	for	for	IN
cord-344093-3bniy5b5	342	14	promoting	promote	VBG
cord-344093-3bniy5b5	342	15	the	the	DT
cord-344093-3bniy5b5	342	16	development	development	NN
cord-344093-3bniy5b5	342	17	of	of	IN
cord-344093-3bniy5b5	342	18	chronic	chronic	JJ
cord-344093-3bniy5b5	342	19	lung	lung	NN
cord-344093-3bniy5b5	342	20	disease	disease	NN
cord-344093-3bniy5b5	342	21	in	in	IN
cord-344093-3bniy5b5	342	22	early	early	JJ
cord-344093-3bniy5b5	342	23	life	life	NN
cord-344093-3bniy5b5	342	24	(	(	-LRB-
cord-344093-3bniy5b5	342	25	196	196	CD
cord-344093-3bniy5b5	342	26	)	)	-RRB-
cord-344093-3bniy5b5	342	27	;	;	:
cord-344093-3bniy5b5	342	28	targeting	target	VBG
cord-344093-3bniy5b5	342	29	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	342	30	by	by	IN
cord-344093-3bniy5b5	342	31	genetic	genetic	JJ
cord-344093-3bniy5b5	342	32	deletion	deletion	NN
cord-344093-3bniy5b5	342	33	or	or	CC
cord-344093-3bniy5b5	342	34	neutralizing	neutralize	VBG
cord-344093-3bniy5b5	342	35	antibody	antibody	NN
cord-344093-3bniy5b5	342	36	application	application	NN
cord-344093-3bniy5b5	342	37	in	in	IN
cord-344093-3bniy5b5	342	38	early	early	JJ
cord-344093-3bniy5b5	342	39	-	-	HYPH
cord-344093-3bniy5b5	342	40	life	life	NN
cord-344093-3bniy5b5	342	41	respiratory	respiratory	JJ
cord-344093-3bniy5b5	342	42	infections	infection	NNS
cord-344093-3bniy5b5	342	43	ameliorated	ameliorate	VBD
cord-344093-3bniy5b5	342	44	infection	infection	NN
cord-344093-3bniy5b5	342	45	-	-	HYPH
cord-344093-3bniy5b5	342	46	induced	induce	VBN
cord-344093-3bniy5b5	342	47	histopathology	histopathology	NN
cord-344093-3bniy5b5	342	48	,	,	,
cord-344093-3bniy5b5	342	49	inflammation	inflammation	NN
cord-344093-3bniy5b5	342	50	,	,	,
cord-344093-3bniy5b5	342	51	as	as	RB
cord-344093-3bniy5b5	342	52	well	well	RB
cord-344093-3bniy5b5	342	53	as	as	IN
cord-344093-3bniy5b5	342	54	emphysema	emphysema	NN
cord-344093-3bniy5b5	342	55	-	-	HYPH
cord-344093-3bniy5b5	342	56	like	like	JJ
cord-344093-3bniy5b5	342	57	alveolar	alveolar	NN
cord-344093-3bniy5b5	342	58	enlargement	enlargement	NN
cord-344093-3bniy5b5	342	59	and	and	CC
cord-344093-3bniy5b5	342	60	lung	lung	NN
cord-344093-3bniy5b5	342	61	function	function	NN
cord-344093-3bniy5b5	342	62	.	.	.
cord-344093-3bniy5b5	343	1	Furthermore	furthermore	RB
cord-344093-3bniy5b5	343	2	,	,	,
cord-344093-3bniy5b5	343	3	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	343	4	was	be	VBD
cord-344093-3bniy5b5	343	5	also	also	RB
cord-344093-3bniy5b5	343	6	shown	show	VBN
cord-344093-3bniy5b5	343	7	to	to	TO
cord-344093-3bniy5b5	343	8	play	play	VB
cord-344093-3bniy5b5	343	9	a	a	DT
cord-344093-3bniy5b5	343	10	role	role	NN
cord-344093-3bniy5b5	343	11	in	in	IN
cord-344093-3bniy5b5	343	12	the	the	DT
cord-344093-3bniy5b5	343	13	development	development	NN
cord-344093-3bniy5b5	343	14	of	of	IN
cord-344093-3bniy5b5	343	15	allergy	allergy	NN
cord-344093-3bniy5b5	343	16	and	and	CC
cord-344093-3bniy5b5	343	17	asthma	asthma	NN
cord-344093-3bniy5b5	343	18	.	.	.
cord-344093-3bniy5b5	344	1	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	344	2	is	be	VBZ
cord-344093-3bniy5b5	344	3	not	not	RB
cord-344093-3bniy5b5	344	4	only	only	RB
cord-344093-3bniy5b5	344	5	elevated	elevate	VBN
cord-344093-3bniy5b5	344	6	in	in	IN
cord-344093-3bniy5b5	344	7	the	the	DT
cord-344093-3bniy5b5	344	8	sputum	sputum	NN
cord-344093-3bniy5b5	344	9	of	of	IN
cord-344093-3bniy5b5	344	10	asthmatic	asthmatic	JJ
cord-344093-3bniy5b5	344	11	patients	patient	NNS
cord-344093-3bniy5b5	344	12	but	but	CC
cord-344093-3bniy5b5	344	13	has	have	VBZ
cord-344093-3bniy5b5	344	14	also	also	RB
cord-344093-3bniy5b5	344	15	been	be	VBN
cord-344093-3bniy5b5	344	16	reported	report	VBN
cord-344093-3bniy5b5	344	17	to	to	TO
cord-344093-3bniy5b5	344	18	be	be	VB
cord-344093-3bniy5b5	344	19	highly	highly	RB
cord-344093-3bniy5b5	344	20	expressed	express	VBN
cord-344093-3bniy5b5	344	21	in	in	IN
cord-344093-3bniy5b5	344	22	an	an	DT
cord-344093-3bniy5b5	344	23	experimental	experimental	JJ
cord-344093-3bniy5b5	344	24	mouse	mouse	NN
cord-344093-3bniy5b5	344	25	model	model	NN
cord-344093-3bniy5b5	344	26	of	of	IN
cord-344093-3bniy5b5	344	27	asthma	asthma	NN
cord-344093-3bniy5b5	344	28	,	,	,
cord-344093-3bniy5b5	344	29	where	where	WRB
cord-344093-3bniy5b5	344	30	it	-PRON-	PRP
cord-344093-3bniy5b5	344	31	induces	induce	VBZ
cord-344093-3bniy5b5	344	32	CCL20	ccl20	IN
cord-344093-3bniy5b5	344	33	secretion	secretion	NN
cord-344093-3bniy5b5	344	34	by	by	IN
cord-344093-3bniy5b5	344	35	bronchial	bronchial	JJ
cord-344093-3bniy5b5	344	36	epithelial	epithelial	JJ
cord-344093-3bniy5b5	344	37	cells	cell	NNS
cord-344093-3bniy5b5	344	38	,	,	,
cord-344093-3bniy5b5	344	39	thus	thus	RB
cord-344093-3bniy5b5	344	40	promoting	promote	VBG
cord-344093-3bniy5b5	344	41	TH2	TH2	NNP
cord-344093-3bniy5b5	344	42	cell	cell	NN
cord-344093-3bniy5b5	344	43	responses	response	NNS
cord-344093-3bniy5b5	344	44	and	and	CC
cord-344093-3bniy5b5	344	45	airway	airway	NNP
cord-344093-3bniy5b5	344	46	hyperreactivity	hyperreactivity	NNP
cord-344093-3bniy5b5	344	47	(	(	-LRB-
cord-344093-3bniy5b5	344	48	197	197	CD
cord-344093-3bniy5b5	344	49	)	)	-RRB-
cord-344093-3bniy5b5	344	50	.	.	.
cord-344093-3bniy5b5	345	1	In	in	IN
cord-344093-3bniy5b5	345	2	COPD	COPD	NNP
cord-344093-3bniy5b5	345	3	,	,	,
cord-344093-3bniy5b5	345	4	acute	acute	JJ
cord-344093-3bniy5b5	345	5	exacerbations	exacerbation	NNS
cord-344093-3bniy5b5	345	6	driven	drive	VBN
cord-344093-3bniy5b5	345	7	by	by	IN
cord-344093-3bniy5b5	345	8	viral	viral	JJ
cord-344093-3bniy5b5	345	9	and	and	CC
cord-344093-3bniy5b5	345	10	bacterial	bacterial	JJ
cord-344093-3bniy5b5	345	11	infection	infection	NN
cord-344093-3bniy5b5	345	12	are	be	VBP
cord-344093-3bniy5b5	345	13	a	a	DT
cord-344093-3bniy5b5	345	14	major	major	JJ
cord-344093-3bniy5b5	345	15	factor	factor	NN
cord-344093-3bniy5b5	345	16	increasing	increase	VBG
cord-344093-3bniy5b5	345	17	both	both	CC
cord-344093-3bniy5b5	345	18	mortality	mortality	NN
cord-344093-3bniy5b5	345	19	and	and	CC
cord-344093-3bniy5b5	345	20	morbidity	morbidity	NN
cord-344093-3bniy5b5	345	21	,	,	,
cord-344093-3bniy5b5	345	22	and	and	CC
cord-344093-3bniy5b5	345	23	both	both	DT
cord-344093-3bniy5b5	345	24	influenza	influenza	NN
cord-344093-3bniy5b5	345	25	and	and	CC
cord-344093-3bniy5b5	345	26	S.	S.	NNP
cord-344093-3bniy5b5	345	27	pneumoniae	pneumoniae	NNS
cord-344093-3bniy5b5	345	28	have	have	VBP
cord-344093-3bniy5b5	345	29	been	be	VBN
cord-344093-3bniy5b5	345	30	identified	identify	VBN
cord-344093-3bniy5b5	345	31	among	among	IN
cord-344093-3bniy5b5	345	32	the	the	DT
cord-344093-3bniy5b5	345	33	most	most	RBS
cord-344093-3bniy5b5	345	34	common	common	JJ
cord-344093-3bniy5b5	345	35	causes	cause	NNS
cord-344093-3bniy5b5	345	36	of	of	IN
cord-344093-3bniy5b5	345	37	COPD	COPD	NNP
cord-344093-3bniy5b5	345	38	exacerbations	exacerbation	NNS
cord-344093-3bniy5b5	345	39	(	(	-LRB-
cord-344093-3bniy5b5	345	40	198	198	CD
cord-344093-3bniy5b5	345	41	)	)	-RRB-
cord-344093-3bniy5b5	345	42	.	.	.
cord-344093-3bniy5b5	346	1	Indeed	indeed	RB
cord-344093-3bniy5b5	346	2	,	,	,
cord-344093-3bniy5b5	346	3	primary	primary	JJ
cord-344093-3bniy5b5	346	4	bronchial	bronchial	JJ
cord-344093-3bniy5b5	346	5	epithelial	epithelial	JJ
cord-344093-3bniy5b5	346	6	cells	cell	NNS
cord-344093-3bniy5b5	346	7	isolated	isolate	VBN
cord-344093-3bniy5b5	346	8	from	from	IN
cord-344093-3bniy5b5	346	9	subjects	subject	NNS
cord-344093-3bniy5b5	346	10	with	with	IN
cord-344093-3bniy5b5	346	11	COPD	COPD	NNP
cord-344093-3bniy5b5	346	12	show	show	VBP
cord-344093-3bniy5b5	346	13	an	an	DT
cord-344093-3bniy5b5	346	14	impaired	impaired	JJ
cord-344093-3bniy5b5	346	15	production	production	NN
cord-344093-3bniy5b5	346	16	of	of	IN
cord-344093-3bniy5b5	346	17	type	type	NN
cord-344093-3bniy5b5	346	18	I	-PRON-	PRP
cord-344093-3bniy5b5	346	19	IFN	IFN	NNP
cord-344093-3bniy5b5	346	20	(	(	-LRB-
cord-344093-3bniy5b5	346	21	199	199	CD
cord-344093-3bniy5b5	346	22	)	)	-RRB-
cord-344093-3bniy5b5	346	23	,	,	,
cord-344093-3bniy5b5	346	24	which	which	WDT
cord-344093-3bniy5b5	346	25	has	have	VBZ
cord-344093-3bniy5b5	346	26	been	be	VBN
cord-344093-3bniy5b5	346	27	implied	imply	VBN
cord-344093-3bniy5b5	346	28	in	in	IN
cord-344093-3bniy5b5	346	29	the	the	DT
cord-344093-3bniy5b5	346	30	enhanced	enhanced	JJ
cord-344093-3bniy5b5	346	31	susceptibility	susceptibility	NN
cord-344093-3bniy5b5	346	32	of	of	IN
cord-344093-3bniy5b5	346	33	COPD	COPD	NNP
cord-344093-3bniy5b5	346	34	patients	patient	NNS
cord-344093-3bniy5b5	346	35	to	to	IN
cord-344093-3bniy5b5	346	36	respiratory	respiratory	JJ
cord-344093-3bniy5b5	346	37	infections	infection	NNS
cord-344093-3bniy5b5	346	38	;	;	:
cord-344093-3bniy5b5	346	39	however	however	RB
cord-344093-3bniy5b5	346	40	,	,	,
cord-344093-3bniy5b5	346	41	even	even	RB
cord-344093-3bniy5b5	346	42	in	in	IN
cord-344093-3bniy5b5	346	43	absence	absence	NN
cord-344093-3bniy5b5	346	44	of	of	IN
cord-344093-3bniy5b5	346	45	high	high	JJ
cord-344093-3bniy5b5	346	46	IFN	IFN	NNP
cord-344093-3bniy5b5	346	47	induction	induction	NN
cord-344093-3bniy5b5	346	48	,	,	,
cord-344093-3bniy5b5	346	49	both	both	CC
cord-344093-3bniy5b5	346	50	an	an	DT
cord-344093-3bniy5b5	346	51	abnormally	abnormally	RB
cord-344093-3bniy5b5	346	52	elevated	elevated	JJ
cord-344093-3bniy5b5	346	53	loss	loss	NN
cord-344093-3bniy5b5	346	54	of	of	IN
cord-344093-3bniy5b5	346	55	alveolar	alveolar	JJ
cord-344093-3bniy5b5	346	56	epithelial	epithelial	JJ
cord-344093-3bniy5b5	346	57	cells	cell	NNS
cord-344093-3bniy5b5	346	58	due	due	JJ
cord-344093-3bniy5b5	346	59	to	to	IN
cord-344093-3bniy5b5	346	60	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	346	61	as	as	RB
cord-344093-3bniy5b5	346	62	well	well	RB
cord-344093-3bniy5b5	346	63	as	as	IN
cord-344093-3bniy5b5	346	64	elevated	elevated	JJ
cord-344093-3bniy5b5	346	65	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	346	66	and	and	CC
cord-344093-3bniy5b5	346	67	DR5	DR5	NNP
cord-344093-3bniy5b5	346	68	levels	level	NNS
cord-344093-3bniy5b5	346	69	were	be	VBD
cord-344093-3bniy5b5	346	70	reported	report	VBN
cord-344093-3bniy5b5	346	71	(	(	-LRB-
cord-344093-3bniy5b5	346	72	200	200	CD
cord-344093-3bniy5b5	346	73	)	)	-RRB-
cord-344093-3bniy5b5	346	74	,	,	,
cord-344093-3bniy5b5	346	75	implying	imply	VBG
cord-344093-3bniy5b5	346	76	a	a	DT
cord-344093-3bniy5b5	346	77	possible	possible	JJ
cord-344093-3bniy5b5	346	78	link	link	NN
cord-344093-3bniy5b5	346	79	between	between	IN
cord-344093-3bniy5b5	346	80	viral	viral	JJ
cord-344093-3bniy5b5	346	81	/	/	SYM
cord-344093-3bniy5b5	346	82	bacterial	bacterial	JJ
cord-344093-3bniy5b5	346	83	induction	induction	NN
cord-344093-3bniy5b5	346	84	of	of	IN
cord-344093-3bniy5b5	346	85	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	346	86	and	and	CC
cord-344093-3bniy5b5	346	87	acute	acute	JJ
cord-344093-3bniy5b5	346	88	exacerbations	exacerbation	NNS
cord-344093-3bniy5b5	346	89	in	in	IN
cord-344093-3bniy5b5	346	90	COPD	COPD	NNP
cord-344093-3bniy5b5	346	91	.	.	.
cord-344093-3bniy5b5	347	1	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	347	2	induction	induction	NN
cord-344093-3bniy5b5	347	3	has	have	VBZ
cord-344093-3bniy5b5	347	4	also	also	RB
cord-344093-3bniy5b5	347	5	been	be	VBN
cord-344093-3bniy5b5	347	6	directly	directly	RB
cord-344093-3bniy5b5	347	7	linked	link	VBN
cord-344093-3bniy5b5	347	8	to	to	IN
cord-344093-3bniy5b5	347	9	cigarette	cigarette	NN
cord-344093-3bniy5b5	347	10	-	-	HYPH
cord-344093-3bniy5b5	347	11	smoke	smoke	NN
cord-344093-3bniy5b5	347	12	exposure	exposure	NN
cord-344093-3bniy5b5	347	13	,	,	,
cord-344093-3bniy5b5	347	14	a	a	DT
cord-344093-3bniy5b5	347	15	common	common	JJ
cord-344093-3bniy5b5	347	16	cause	cause	NN
cord-344093-3bniy5b5	347	17	of	of	IN
cord-344093-3bniy5b5	347	18	COPD	COPD	NNP
cord-344093-3bniy5b5	347	19	,	,	,
cord-344093-3bniy5b5	347	20	and	and	CC
cord-344093-3bniy5b5	347	21	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	347	22	deficiency	deficiency	NN
cord-344093-3bniy5b5	347	23	resulted	result	VBD
cord-344093-3bniy5b5	347	24	in	in	IN
cord-344093-3bniy5b5	347	25	decreased	decrease	VBN
cord-344093-3bniy5b5	347	26	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	347	27	inflammation	inflammation	NN
cord-344093-3bniy5b5	347	28	and	and	CC
cord-344093-3bniy5b5	347	29	emphysema	emphysema	NN
cord-344093-3bniy5b5	347	30	-	-	HYPH
cord-344093-3bniy5b5	347	31	like	like	JJ
cord-344093-3bniy5b5	347	32	alveolar	alveolar	NN
cord-344093-3bniy5b5	347	33	enlargement	enlargement	NN
cord-344093-3bniy5b5	347	34	in	in	IN
cord-344093-3bniy5b5	347	35	vivo	vivo	NNP
cord-344093-3bniy5b5	347	36	(	(	-LRB-
cord-344093-3bniy5b5	347	37	201	201	CD
cord-344093-3bniy5b5	347	38	)	)	-RRB-
cord-344093-3bniy5b5	347	39	.	.	.
cord-344093-3bniy5b5	348	1	Moreover	moreover	RB
cord-344093-3bniy5b5	348	2	,	,	,
cord-344093-3bniy5b5	348	3	increased	increase	VBN
cord-344093-3bniy5b5	348	4	levels	level	NNS
cord-344093-3bniy5b5	348	5	of	of	IN
cord-344093-3bniy5b5	348	6	both	both	DT
cord-344093-3bniy5b5	348	7	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	348	8	and	and	CC
cord-344093-3bniy5b5	348	9	DR5	DR5	NNP
cord-344093-3bniy5b5	348	10	were	be	VBD
cord-344093-3bniy5b5	348	11	associated	associate	VBN
cord-344093-3bniy5b5	348	12	to	to	IN
cord-344093-3bniy5b5	348	13	impaired	impaired	JJ
cord-344093-3bniy5b5	348	14	lung	lung	NN
cord-344093-3bniy5b5	348	15	function	function	NN
cord-344093-3bniy5b5	348	16	and	and	CC
cord-344093-3bniy5b5	348	17	increased	increase	VBN
cord-344093-3bniy5b5	348	18	systemic	systemic	JJ
cord-344093-3bniy5b5	348	19	inflammation	inflammation	NN
cord-344093-3bniy5b5	348	20	in	in	IN
cord-344093-3bniy5b5	348	21	human	human	JJ
cord-344093-3bniy5b5	348	22	COPD	COPD	NNP
cord-344093-3bniy5b5	348	23	patients	patient	NNS
cord-344093-3bniy5b5	348	24	(	(	-LRB-
cord-344093-3bniy5b5	348	25	202	202	CD
cord-344093-3bniy5b5	348	26	)	)	-RRB-
cord-344093-3bniy5b5	348	27	.	.	.
cord-344093-3bniy5b5	349	1	While	while	IN
cord-344093-3bniy5b5	349	2	alveolar	alveolar	JJ
cord-344093-3bniy5b5	349	3	epithelial	epithelial	JJ
cord-344093-3bniy5b5	349	4	cell	cell	NN
cord-344093-3bniy5b5	349	5	death	death	NN
cord-344093-3bniy5b5	349	6	is	be	VBZ
cord-344093-3bniy5b5	349	7	closely	closely	RB
cord-344093-3bniy5b5	349	8	connected	connected	JJ
cord-344093-3bniy5b5	349	9	to	to	IN
cord-344093-3bniy5b5	349	10	idiopathic	idiopathic	JJ
cord-344093-3bniy5b5	349	11	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	349	12	fibrosis	fibrosis	NN
cord-344093-3bniy5b5	349	13	(	(	-LRB-
cord-344093-3bniy5b5	349	14	IPF	IPF	NNP
cord-344093-3bniy5b5	349	15	)	)	-RRB-
cord-344093-3bniy5b5	349	16	,	,	,
cord-344093-3bniy5b5	349	17	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	349	18	and	and	CC
cord-344093-3bniy5b5	349	19	its	-PRON-	PRP$
cord-344093-3bniy5b5	349	20	receptors	receptor	NNS
cord-344093-3bniy5b5	349	21	DR4	dr4	VBP
cord-344093-3bniy5b5	349	22	and	and	CC
cord-344093-3bniy5b5	349	23	DR5	DR5	NNP
cord-344093-3bniy5b5	349	24	in	in	IN
cord-344093-3bniy5b5	349	25	AEC	AEC	NNP
cord-344093-3bniy5b5	349	26	were	be	VBD
cord-344093-3bniy5b5	349	27	shown	show	VBN
cord-344093-3bniy5b5	349	28	to	to	TO
cord-344093-3bniy5b5	349	29	be	be	VB
cord-344093-3bniy5b5	349	30	upregulated	upregulate	VBN
cord-344093-3bniy5b5	349	31	in	in	IN
cord-344093-3bniy5b5	349	32	IPF	IPF	NNP
cord-344093-3bniy5b5	349	33	lungs	lung	NNS
cord-344093-3bniy5b5	349	34	(	(	-LRB-
cord-344093-3bniy5b5	349	35	129	129	CD
cord-344093-3bniy5b5	349	36	)	)	-RRB-
cord-344093-3bniy5b5	349	37	.	.	.
cord-344093-3bniy5b5	350	1	Also	also	RB
cord-344093-3bniy5b5	350	2	,	,	,
cord-344093-3bniy5b5	350	3	in	in	IN
cord-344093-3bniy5b5	350	4	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	350	5	arterial	arterial	JJ
cord-344093-3bniy5b5	350	6	hypertension	hypertension	NN
cord-344093-3bniy5b5	350	7	virus	virus	NN
cord-344093-3bniy5b5	350	8	infection	infection	NN
cord-344093-3bniy5b5	350	9	is	be	VBZ
cord-344093-3bniy5b5	350	10	considered	consider	VBN
cord-344093-3bniy5b5	350	11	to	to	TO
cord-344093-3bniy5b5	350	12	be	be	VB
cord-344093-3bniy5b5	350	13	a	a	DT
cord-344093-3bniy5b5	350	14	possible	possible	JJ
cord-344093-3bniy5b5	350	15	risk	risk	NN
cord-344093-3bniy5b5	350	16	factor	factor	NN
cord-344093-3bniy5b5	350	17	(	(	-LRB-
cord-344093-3bniy5b5	350	18	203	203	CD
cord-344093-3bniy5b5	350	19	)	)	-RRB-
cord-344093-3bniy5b5	350	20	,	,	,
cord-344093-3bniy5b5	350	21	and	and	CC
cord-344093-3bniy5b5	350	22	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	350	23	hypertension	hypertension	NN
cord-344093-3bniy5b5	350	24	has	have	VBZ
cord-344093-3bniy5b5	350	25	been	be	VBN
cord-344093-3bniy5b5	350	26	reported	report	VBN
cord-344093-3bniy5b5	350	27	to	to	TO
cord-344093-3bniy5b5	350	28	be	be	VB
cord-344093-3bniy5b5	350	29	a	a	DT
cord-344093-3bniy5b5	350	30	side	side	JJ
cord-344093-3bniy5b5	350	31	effect	effect	NN
cord-344093-3bniy5b5	350	32	of	of	IN
cord-344093-3bniy5b5	350	33	prolonged	prolong	VBN
cord-344093-3bniy5b5	350	34	treatment	treatment	NN
cord-344093-3bniy5b5	350	35	with	with	IN
cord-344093-3bniy5b5	350	36	type	type	NN
cord-344093-3bniy5b5	351	1	I	-PRON-	PRP
cord-344093-3bniy5b5	351	2	IFN	IFN	NNP
cord-344093-3bniy5b5	351	3	(	(	-LRB-
cord-344093-3bniy5b5	351	4	204	204	CD
cord-344093-3bniy5b5	351	5	,	,	,
cord-344093-3bniy5b5	351	6	205	205	CD
cord-344093-3bniy5b5	351	7	)	)	-RRB-
cord-344093-3bniy5b5	351	8	.	.	.
cord-344093-3bniy5b5	352	1	In	in	IN
cord-344093-3bniy5b5	352	2	line	line	NN
cord-344093-3bniy5b5	352	3	,	,	,
cord-344093-3bniy5b5	352	4	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	352	5	has	have	VBZ
cord-344093-3bniy5b5	352	6	been	be	VBN
cord-344093-3bniy5b5	352	7	closely	closely	RB
cord-344093-3bniy5b5	352	8	linked	link	VBN
cord-344093-3bniy5b5	352	9	to	to	IN
cord-344093-3bniy5b5	352	10	disease	disease	NN
cord-344093-3bniy5b5	352	11	progression	progression	NN
cord-344093-3bniy5b5	352	12	in	in	IN
cord-344093-3bniy5b5	352	13	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	352	14	hypertension	hypertension	NN
cord-344093-3bniy5b5	352	15	.	.	.
cord-344093-3bniy5b5	353	1	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	353	2	has	have	VBZ
cord-344093-3bniy5b5	353	3	been	be	VBN
cord-344093-3bniy5b5	353	4	found	find	VBN
cord-344093-3bniy5b5	353	5	to	to	TO
cord-344093-3bniy5b5	353	6	be	be	VB
cord-344093-3bniy5b5	353	7	increased	increase	VBN
cord-344093-3bniy5b5	353	8	within	within	IN
cord-344093-3bniy5b5	353	9	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	353	10	vascular	vascular	JJ
cord-344093-3bniy5b5	353	11	lesions	lesion	NNS
cord-344093-3bniy5b5	353	12	of	of	IN
cord-344093-3bniy5b5	353	13	patients	patient	NNS
cord-344093-3bniy5b5	353	14	with	with	IN
cord-344093-3bniy5b5	353	15	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	353	16	hypertension	hypertension	NN
cord-344093-3bniy5b5	353	17	(	(	-LRB-
cord-344093-3bniy5b5	353	18	206	206	CD
cord-344093-3bniy5b5	353	19	)	)	-RRB-
cord-344093-3bniy5b5	353	20	and	and	CC
cord-344093-3bniy5b5	353	21	also	also	RB
cord-344093-3bniy5b5	353	22	in	in	IN
cord-344093-3bniy5b5	353	23	a	a	DT
cord-344093-3bniy5b5	353	24	mouse	mouse	NN
cord-344093-3bniy5b5	353	25	model	model	NN
cord-344093-3bniy5b5	353	26	of	of	IN
cord-344093-3bniy5b5	353	27	hypoxia	hypoxia	NN
cord-344093-3bniy5b5	353	28	-	-	HYPH
cord-344093-3bniy5b5	353	29	induced	induce	VBN
cord-344093-3bniy5b5	353	30	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	353	31	hypertension	hypertension	NN
cord-344093-3bniy5b5	353	32	,	,	,
cord-344093-3bniy5b5	353	33	levels	level	NNS
cord-344093-3bniy5b5	353	34	of	of	IN
cord-344093-3bniy5b5	353	35	soluble	soluble	JJ
cord-344093-3bniy5b5	353	36	TRAIL	trail	NN
cord-344093-3bniy5b5	353	37	correlated	correlate	VBN
cord-344093-3bniy5b5	353	38	with	with	IN
cord-344093-3bniy5b5	353	39	right	right	JJ
cord-344093-3bniy5b5	353	40	ventricular	ventricular	JJ
cord-344093-3bniy5b5	353	41	systolic	systolic	JJ
cord-344093-3bniy5b5	353	42	pressure	pressure	NN
cord-344093-3bniy5b5	353	43	,	,	,
cord-344093-3bniy5b5	353	44	right	right	JJ
cord-344093-3bniy5b5	353	45	ventricular	ventricular	JJ
cord-344093-3bniy5b5	353	46	hypertrophy	hypertrophy	NN
cord-344093-3bniy5b5	353	47	,	,	,
cord-344093-3bniy5b5	353	48	and	and	CC
cord-344093-3bniy5b5	353	49	pathologic	pathologic	JJ
cord-344093-3bniy5b5	353	50	alterations	alteration	NNS
cord-344093-3bniy5b5	353	51	(	(	-LRB-
cord-344093-3bniy5b5	353	52	33	33	CD
cord-344093-3bniy5b5	353	53	,	,	,
cord-344093-3bniy5b5	353	54	34	34	CD
cord-344093-3bniy5b5	353	55	)	)	-RRB-
cord-344093-3bniy5b5	353	56	.	.	.
cord-344093-3bniy5b5	354	1	Importantly	importantly	RB
cord-344093-3bniy5b5	354	2	,	,	,
cord-344093-3bniy5b5	354	3	neutralizing	neutralize	VBG
cord-344093-3bniy5b5	354	4	antibody	antibody	NN
cord-344093-3bniy5b5	354	5	-	-	HYPH
cord-344093-3bniy5b5	354	6	treatment	treatment	NN
cord-344093-3bniy5b5	354	7	against	against	IN
cord-344093-3bniy5b5	354	8	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	354	9	showed	show	VBD
cord-344093-3bniy5b5	354	10	positive	positive	JJ
cord-344093-3bniy5b5	354	11	effects	effect	NNS
cord-344093-3bniy5b5	354	12	on	on	IN
cord-344093-3bniy5b5	354	13	survival	survival	NN
cord-344093-3bniy5b5	354	14	while	while	IN
cord-344093-3bniy5b5	354	15	reducing	reduce	VBG
cord-344093-3bniy5b5	354	16	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	354	17	vascular	vascular	JJ
cord-344093-3bniy5b5	354	18	remodeling	remodeling	NN
cord-344093-3bniy5b5	354	19	(	(	-LRB-
cord-344093-3bniy5b5	354	20	207	207	CD
cord-344093-3bniy5b5	354	21	)	)	-RRB-
cord-344093-3bniy5b5	354	22	.	.	.
cord-344093-3bniy5b5	355	1	Notably	notably	RB
cord-344093-3bniy5b5	355	2	,	,	,
cord-344093-3bniy5b5	355	3	the	the	DT
cord-344093-3bniy5b5	355	4	extent	extent	NN
cord-344093-3bniy5b5	355	5	to	to	TO
cord-344093-3bniy5b5	355	6	which	which	WDT
cord-344093-3bniy5b5	355	7	infection	infection	NN
cord-344093-3bniy5b5	355	8	-	-	HYPH
cord-344093-3bniy5b5	355	9	induced	induce	VBN
cord-344093-3bniy5b5	355	10	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	355	11	release	release	NN
cord-344093-3bniy5b5	355	12	causes	cause	NNS
cord-344093-3bniy5b5	355	13	or	or	CC
cord-344093-3bniy5b5	355	14	exacerbates	exacerbate	VBZ
cord-344093-3bniy5b5	355	15	chronic	chronic	JJ
cord-344093-3bniy5b5	355	16	lung	lung	NN
cord-344093-3bniy5b5	355	17	disease	disease	NN
cord-344093-3bniy5b5	355	18	or	or	CC
cord-344093-3bniy5b5	356	1	in	in	IN
cord-344093-3bniy5b5	356	2	how	how	WRB
cord-344093-3bniy5b5	356	3	far	far	RB
cord-344093-3bniy5b5	356	4	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	356	5	production	production	NN
cord-344093-3bniy5b5	356	6	in	in	IN
cord-344093-3bniy5b5	356	7	chronic	chronic	JJ
cord-344093-3bniy5b5	356	8	lung	lung	NN
cord-344093-3bniy5b5	356	9	diseases	disease	NNS
cord-344093-3bniy5b5	356	10	affects	affect	VBZ
cord-344093-3bniy5b5	356	11	susceptibility	susceptibility	NN
cord-344093-3bniy5b5	356	12	to	to	IN
cord-344093-3bniy5b5	356	13	respiratory	respiratory	JJ
cord-344093-3bniy5b5	356	14	viral	viral	JJ
cord-344093-3bniy5b5	356	15	and	and	CC
cord-344093-3bniy5b5	356	16	complicating	complicate	VBG
cord-344093-3bniy5b5	356	17	bacterial	bacterial	JJ
cord-344093-3bniy5b5	356	18	infection	infection	NN
cord-344093-3bniy5b5	356	19	remains	remain	VBZ
cord-344093-3bniy5b5	356	20	to	to	TO
cord-344093-3bniy5b5	356	21	be	be	VB
cord-344093-3bniy5b5	356	22	elucidated	elucidate	VBN
cord-344093-3bniy5b5	356	23	.	.	.
cord-344093-3bniy5b5	357	1	Respiratory	respiratory	JJ
cord-344093-3bniy5b5	357	2	viral	viral	JJ
cord-344093-3bniy5b5	357	3	infections	infection	NNS
cord-344093-3bniy5b5	357	4	are	be	VBP
cord-344093-3bniy5b5	357	5	major	major	JJ
cord-344093-3bniy5b5	357	6	causative	causative	JJ
cord-344093-3bniy5b5	357	7	agents	agent	NNS
cord-344093-3bniy5b5	357	8	for	for	IN
cord-344093-3bniy5b5	357	9	lung	lung	NN
cord-344093-3bniy5b5	357	10	injury	injury	NN
cord-344093-3bniy5b5	357	11	and	and	CC
cord-344093-3bniy5b5	357	12	ARDS	ARDS	NNP
cord-344093-3bniy5b5	357	13	;	;	:
cord-344093-3bniy5b5	357	14	however	however	RB
cord-344093-3bniy5b5	357	15	,	,	,
cord-344093-3bniy5b5	357	16	in	in	IN
cord-344093-3bniy5b5	357	17	many	many	JJ
cord-344093-3bniy5b5	357	18	cases	case	NNS
cord-344093-3bniy5b5	357	19	antivirals	antiviral	NNS
cord-344093-3bniy5b5	357	20	are	be	VBP
cord-344093-3bniy5b5	357	21	not	not	RB
cord-344093-3bniy5b5	357	22	sufficient	sufficient	JJ
cord-344093-3bniy5b5	357	23	to	to	TO
cord-344093-3bniy5b5	357	24	limit	limit	VB
cord-344093-3bniy5b5	357	25	disease	disease	NN
cord-344093-3bniy5b5	357	26	(	(	-LRB-
cord-344093-3bniy5b5	357	27	208	208	CD
cord-344093-3bniy5b5	357	28	)	)	-RRB-
cord-344093-3bniy5b5	357	29	.	.	.
cord-344093-3bniy5b5	358	1	Besides	besides	IN
cord-344093-3bniy5b5	358	2	the	the	DT
cord-344093-3bniy5b5	358	3	fact	fact	NN
cord-344093-3bniy5b5	358	4	that	that	IN
cord-344093-3bniy5b5	358	5	most	most	JJS
cord-344093-3bniy5b5	358	6	viruses	virus	NNS
cord-344093-3bniy5b5	358	7	are	be	VBP
cord-344093-3bniy5b5	358	8	subject	subject	JJ
cord-344093-3bniy5b5	358	9	to	to	IN
cord-344093-3bniy5b5	358	10	strong	strong	JJ
cord-344093-3bniy5b5	358	11	selective	selective	JJ
cord-344093-3bniy5b5	358	12	pressures	pressure	NNS
cord-344093-3bniy5b5	358	13	that	that	WDT
cord-344093-3bniy5b5	358	14	favor	favor	VBP
cord-344093-3bniy5b5	358	15	quickly	quickly	RB
cord-344093-3bniy5b5	358	16	evolving	evolve	VBG
cord-344093-3bniy5b5	358	17	,	,	,
cord-344093-3bniy5b5	358	18	drug	drug	NN
cord-344093-3bniy5b5	358	19	-	-	HYPH
cord-344093-3bniy5b5	358	20	resistant	resistant	JJ
cord-344093-3bniy5b5	358	21	virus	virus	NN
cord-344093-3bniy5b5	358	22	variants	variant	NNS
cord-344093-3bniy5b5	358	23	,	,	,
cord-344093-3bniy5b5	358	24	recent	recent	JJ
cord-344093-3bniy5b5	358	25	advances	advance	NNS
cord-344093-3bniy5b5	358	26	in	in	IN
cord-344093-3bniy5b5	358	27	understanding	understand	VBG
cord-344093-3bniy5b5	358	28	the	the	DT
cord-344093-3bniy5b5	358	29	processes	process	NNS
cord-344093-3bniy5b5	358	30	that	that	WDT
cord-344093-3bniy5b5	358	31	contribute	contribute	VBP
cord-344093-3bniy5b5	358	32	to	to	IN
cord-344093-3bniy5b5	358	33	tissue	tissue	NN
cord-344093-3bniy5b5	358	34	injury	injury	NN
cord-344093-3bniy5b5	358	35	and	and	CC
cord-344093-3bniy5b5	358	36	ARDS	ARDS	NNP
cord-344093-3bniy5b5	358	37	highlight	highlight	VBP
cord-344093-3bniy5b5	358	38	a	a	DT
cord-344093-3bniy5b5	358	39	crucial	crucial	JJ
cord-344093-3bniy5b5	358	40	role	role	NN
cord-344093-3bniy5b5	358	41	of	of	IN
cord-344093-3bniy5b5	358	42	immune	immune	NN
cord-344093-3bniy5b5	358	43	-	-	HYPH
cord-344093-3bniy5b5	358	44	related	relate	VBN
cord-344093-3bniy5b5	358	45	,	,	,
cord-344093-3bniy5b5	358	46	IFN	IFN	NNP
cord-344093-3bniy5b5	358	47	-	-	HYPH
cord-344093-3bniy5b5	358	48	driven	drive	VBN
cord-344093-3bniy5b5	358	49	events	event	NNS
cord-344093-3bniy5b5	358	50	.	.	.
cord-344093-3bniy5b5	359	1	Therefore	therefore	RB
cord-344093-3bniy5b5	359	2	,	,	,
cord-344093-3bniy5b5	359	3	novel	novel	JJ
cord-344093-3bniy5b5	359	4	therapeutic	therapeutic	JJ
cord-344093-3bniy5b5	359	5	strategies	strategy	NNS
cord-344093-3bniy5b5	359	6	often	often	RB
cord-344093-3bniy5b5	359	7	aim	aim	VBP
cord-344093-3bniy5b5	359	8	to	to	TO
cord-344093-3bniy5b5	359	9	improve	improve	VB
cord-344093-3bniy5b5	359	10	the	the	DT
cord-344093-3bniy5b5	359	11	outcome	outcome	NN
cord-344093-3bniy5b5	359	12	of	of	IN
cord-344093-3bniy5b5	359	13	severe	severe	JJ
cord-344093-3bniy5b5	359	14	respiratory	respiratory	JJ
cord-344093-3bniy5b5	359	15	infection	infection	NN
cord-344093-3bniy5b5	359	16	by	by	IN
cord-344093-3bniy5b5	359	17	modulating	modulate	VBG
cord-344093-3bniy5b5	359	18	host	host	NN
cord-344093-3bniy5b5	359	19	cell	cell	NN
cord-344093-3bniy5b5	359	20	responses	response	NNS
cord-344093-3bniy5b5	359	21	;	;	:
cord-344093-3bniy5b5	359	22	however	however	RB
cord-344093-3bniy5b5	359	23	,	,	,
cord-344093-3bniy5b5	359	24	to	to	IN
cord-344093-3bniy5b5	359	25	date	date	NN
cord-344093-3bniy5b5	359	26	,	,	,
cord-344093-3bniy5b5	359	27	clinical	clinical	JJ
cord-344093-3bniy5b5	359	28	trials	trial	NNS
cord-344093-3bniy5b5	359	29	trying	try	VBG
cord-344093-3bniy5b5	359	30	to	to	TO
cord-344093-3bniy5b5	359	31	improve	improve	VB
cord-344093-3bniy5b5	359	32	severe	severe	JJ
cord-344093-3bniy5b5	359	33	viral	viral	JJ
cord-344093-3bniy5b5	359	34	infections	infection	NNS
cord-344093-3bniy5b5	359	35	or	or	CC
cord-344093-3bniy5b5	359	36	ARDS	ARDS	NNP
cord-344093-3bniy5b5	359	37	outcomes	outcome	NNS
cord-344093-3bniy5b5	359	38	by	by	IN
cord-344093-3bniy5b5	359	39	targeting	target	VBG
cord-344093-3bniy5b5	359	40	host	host	NN
cord-344093-3bniy5b5	359	41	pathways	pathway	NNS
cord-344093-3bniy5b5	359	42	have	have	VBP
cord-344093-3bniy5b5	359	43	not	not	RB
cord-344093-3bniy5b5	359	44	resulted	result	VBN
cord-344093-3bniy5b5	359	45	in	in	IN
cord-344093-3bniy5b5	359	46	approval	approval	NN
cord-344093-3bniy5b5	359	47	of	of	IN
cord-344093-3bniy5b5	359	48	new	new	JJ
cord-344093-3bniy5b5	359	49	drugs	drug	NNS
cord-344093-3bniy5b5	359	50	(	(	-LRB-
cord-344093-3bniy5b5	359	51	122	122	CD
cord-344093-3bniy5b5	359	52	)	)	-RRB-
cord-344093-3bniy5b5	359	53	.	.	.
cord-344093-3bniy5b5	360	1	Of	of	IN
cord-344093-3bniy5b5	360	2	note	note	NN
cord-344093-3bniy5b5	360	3	,	,	,
cord-344093-3bniy5b5	360	4	for	for	IN
cord-344093-3bniy5b5	360	5	establishment	establishment	NN
cord-344093-3bniy5b5	360	6	of	of	IN
cord-344093-3bniy5b5	360	7	such	such	JJ
cord-344093-3bniy5b5	360	8	therapies	therapy	NNS
cord-344093-3bniy5b5	360	9	it	-PRON-	PRP
cord-344093-3bniy5b5	360	10	has	have	VBZ
cord-344093-3bniy5b5	360	11	to	to	TO
cord-344093-3bniy5b5	360	12	be	be	VB
cord-344093-3bniy5b5	360	13	considered	consider	VBN
cord-344093-3bniy5b5	360	14	that	that	IN
cord-344093-3bniy5b5	360	15	the	the	DT
cord-344093-3bniy5b5	360	16	timing	timing	NN
cord-344093-3bniy5b5	360	17	and	and	CC
cord-344093-3bniy5b5	360	18	intensity	intensity	NN
cord-344093-3bniy5b5	360	19	of	of	IN
cord-344093-3bniy5b5	360	20	induction	induction	NN
cord-344093-3bniy5b5	360	21	and	and	CC
cord-344093-3bniy5b5	360	22	amplification	amplification	NN
cord-344093-3bniy5b5	360	23	as	as	RB
cord-344093-3bniy5b5	360	24	well	well	RB
cord-344093-3bniy5b5	360	25	as	as	IN
cord-344093-3bniy5b5	360	26	of	of	IN
cord-344093-3bniy5b5	360	27	dampening	dampening	NN
cord-344093-3bniy5b5	360	28	and	and	CC
cord-344093-3bniy5b5	360	29	termination	termination	NN
cord-344093-3bniy5b5	360	30	of	of	IN
cord-344093-3bniy5b5	360	31	the	the	DT
cord-344093-3bniy5b5	360	32	IFN	IFN	NNP
cord-344093-3bniy5b5	360	33	-	-	HYPH
cord-344093-3bniy5b5	360	34	driven	drive	VBN
cord-344093-3bniy5b5	360	35	immune	immune	JJ
cord-344093-3bniy5b5	360	36	response	response	NN
cord-344093-3bniy5b5	360	37	needs	need	VBZ
cord-344093-3bniy5b5	360	38	to	to	TO
cord-344093-3bniy5b5	360	39	precisely	precisely	RB
cord-344093-3bniy5b5	360	40	match	match	VB
cord-344093-3bniy5b5	360	41	the	the	DT
cord-344093-3bniy5b5	360	42	pathogen	pathogen	NN
cord-344093-3bniy5b5	360	43	-	-	HYPH
cord-344093-3bniy5b5	360	44	and	and	CC
cord-344093-3bniy5b5	360	45	organ	organ	NN
cord-344093-3bniy5b5	360	46	-	-	HYPH
cord-344093-3bniy5b5	360	47	specific	specific	JJ
cord-344093-3bniy5b5	360	48	requirements	requirement	NNS
cord-344093-3bniy5b5	360	49	of	of	IN
cord-344093-3bniy5b5	360	50	a	a	DT
cord-344093-3bniy5b5	360	51	given	give	VBN
cord-344093-3bniy5b5	360	52	infection	infection	NN
cord-344093-3bniy5b5	360	53	.	.	.
cord-344093-3bniy5b5	361	1	A	a	DT
cord-344093-3bniy5b5	361	2	non	non	JJ
cord-344093-3bniy5b5	361	3	-	-	JJ
cord-344093-3bniy5b5	361	4	controlled	controlled	JJ
cord-344093-3bniy5b5	361	5	regulation	regulation	NN
cord-344093-3bniy5b5	361	6	of	of	IN
cord-344093-3bniy5b5	361	7	these	these	DT
cord-344093-3bniy5b5	361	8	processes	process	NNS
cord-344093-3bniy5b5	361	9	may	may	MD
cord-344093-3bniy5b5	361	10	lead	lead	VB
cord-344093-3bniy5b5	361	11	to	to	IN
cord-344093-3bniy5b5	361	12	either	either	CC
cord-344093-3bniy5b5	361	13	an	an	DT
cord-344093-3bniy5b5	361	14	unrestricted	unrestricted	JJ
cord-344093-3bniy5b5	361	15	pathogen	pathogen	NN
cord-344093-3bniy5b5	361	16	spreading	spread	VBG
cord-344093-3bniy5b5	361	17	or	or	CC
cord-344093-3bniy5b5	361	18	,	,	,
cord-344093-3bniy5b5	361	19	on	on	IN
cord-344093-3bniy5b5	361	20	the	the	DT
cord-344093-3bniy5b5	361	21	other	other	JJ
cord-344093-3bniy5b5	361	22	extreme	extreme	NN
cord-344093-3bniy5b5	361	23	,	,	,
cord-344093-3bniy5b5	361	24	to	to	IN
cord-344093-3bniy5b5	361	25	an	an	DT
cord-344093-3bniy5b5	361	26	overshooting	overshoot	VBG
cord-344093-3bniy5b5	361	27	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	361	28	response	response	NN
cord-344093-3bniy5b5	361	29	,	,	,
cord-344093-3bniy5b5	361	30	including	include	VBG
cord-344093-3bniy5b5	361	31	the	the	DT
cord-344093-3bniy5b5	361	32	increased	increase	VBN
cord-344093-3bniy5b5	361	33	production	production	NN
cord-344093-3bniy5b5	361	34	of	of	IN
cord-344093-3bniy5b5	361	35	pro	pro	JJ
cord-344093-3bniy5b5	361	36	-	-	JJ
cord-344093-3bniy5b5	361	37	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	361	38	and	and	CC
cord-344093-3bniy5b5	361	39	proapoptotic	proapoptotic	JJ
cord-344093-3bniy5b5	361	40	mediators	mediator	NNS
cord-344093-3bniy5b5	361	41	,	,	,
cord-344093-3bniy5b5	361	42	elevated	elevated	JJ
cord-344093-3bniy5b5	361	43	levels	level	NNS
cord-344093-3bniy5b5	361	44	of	of	IN
cord-344093-3bniy5b5	361	45	recruited	recruit	VBN
cord-344093-3bniy5b5	361	46	immune	immune	JJ
cord-344093-3bniy5b5	361	47	cells	cell	NNS
cord-344093-3bniy5b5	361	48	,	,	,
cord-344093-3bniy5b5	361	49	and/or	and/or	CC
cord-344093-3bniy5b5	361	50	aberrant	aberrant	JJ
cord-344093-3bniy5b5	361	51	repair	repair	NN
cord-344093-3bniy5b5	361	52	processes	process	NNS
cord-344093-3bniy5b5	361	53	.	.	.
cord-344093-3bniy5b5	362	1	Notably	notably	RB
cord-344093-3bniy5b5	362	2	,	,	,
cord-344093-3bniy5b5	362	3	both	both	CC
cord-344093-3bniy5b5	362	4	too	too	RB
cord-344093-3bniy5b5	362	5	low	low	JJ
cord-344093-3bniy5b5	362	6	and	and	CC
cord-344093-3bniy5b5	362	7	too	too	RB
cord-344093-3bniy5b5	362	8	high	high	JJ
cord-344093-3bniy5b5	362	9	levels	level	NNS
cord-344093-3bniy5b5	362	10	of	of	IN
cord-344093-3bniy5b5	362	11	IFN	IFN	NNP
cord-344093-3bniy5b5	362	12	-	-	HYPH
cord-344093-3bniy5b5	362	13	induced	induce	VBN
cord-344093-3bniy5b5	362	14	effects	effect	NNS
cord-344093-3bniy5b5	362	15	facilitate	facilitate	VBP
cord-344093-3bniy5b5	362	16	disease	disease	NN
cord-344093-3bniy5b5	362	17	progression	progression	NN
cord-344093-3bniy5b5	362	18	with	with	IN
cord-344093-3bniy5b5	362	19	a	a	DT
cord-344093-3bniy5b5	362	20	possible	possible	JJ
cord-344093-3bniy5b5	362	21	increase	increase	NN
cord-344093-3bniy5b5	362	22	of	of	IN
cord-344093-3bniy5b5	362	23	fatal	fatal	JJ
cord-344093-3bniy5b5	362	24	outcomes	outcome	NNS
cord-344093-3bniy5b5	362	25	in	in	IN
cord-344093-3bniy5b5	362	26	ARDS	ARDS	NNP
cord-344093-3bniy5b5	362	27	patients	patient	NNS
cord-344093-3bniy5b5	362	28	(	(	-LRB-
cord-344093-3bniy5b5	362	29	78	78	CD
cord-344093-3bniy5b5	362	30	)	)	-RRB-
cord-344093-3bniy5b5	362	31	.	.	.
cord-344093-3bniy5b5	363	1	Accordingly	accordingly	RB
cord-344093-3bniy5b5	363	2	,	,	,
cord-344093-3bniy5b5	363	3	preclinical	preclinical	JJ
cord-344093-3bniy5b5	363	4	in	in	IN
cord-344093-3bniy5b5	363	5	vivo	vivo	NN
cord-344093-3bniy5b5	363	6	studies	study	NNS
cord-344093-3bniy5b5	363	7	of	of	IN
cord-344093-3bniy5b5	363	8	IFN	IFN	NNP
cord-344093-3bniy5b5	363	9	-	-	HYPH
cord-344093-3bniy5b5	363	10	directed	direct	VBN
cord-344093-3bniy5b5	363	11	therapies	therapy	NNS
cord-344093-3bniy5b5	363	12	yielded	yield	VBD
cord-344093-3bniy5b5	363	13	seemingly	seemingly	RB
cord-344093-3bniy5b5	363	14	adverse	adverse	JJ
cord-344093-3bniy5b5	363	15	results	result	NNS
cord-344093-3bniy5b5	363	16	,	,	,
cord-344093-3bniy5b5	363	17	depending	depend	VBG
cord-344093-3bniy5b5	363	18	on	on	IN
cord-344093-3bniy5b5	363	19	the	the	DT
cord-344093-3bniy5b5	363	20	context	context	NN
cord-344093-3bniy5b5	363	21	,	,	,
cord-344093-3bniy5b5	363	22	timing	timing	NN
cord-344093-3bniy5b5	363	23	,	,	,
cord-344093-3bniy5b5	363	24	and	and	CC
cord-344093-3bniy5b5	363	25	dosage	dosage	NN
cord-344093-3bniy5b5	363	26	of	of	IN
cord-344093-3bniy5b5	363	27	IFN	IFN	NNP
cord-344093-3bniy5b5	363	28	modulation	modulation	NN
cord-344093-3bniy5b5	363	29	.	.	.
cord-344093-3bniy5b5	364	1	However	however	RB
cord-344093-3bniy5b5	364	2	,	,	,
cord-344093-3bniy5b5	364	3	in	in	IN
cord-344093-3bniy5b5	364	4	multiple	multiple	JJ
cord-344093-3bniy5b5	364	5	settings	setting	NNS
cord-344093-3bniy5b5	364	6	of	of	IN
cord-344093-3bniy5b5	364	7	acute	acute	JJ
cord-344093-3bniy5b5	364	8	respiratory	respiratory	JJ
cord-344093-3bniy5b5	364	9	viral	viral	JJ
cord-344093-3bniy5b5	364	10	infection	infection	NN
cord-344093-3bniy5b5	364	11	,	,	,
cord-344093-3bniy5b5	364	12	studies	study	NNS
cord-344093-3bniy5b5	364	13	demonstrate	demonstrate	VBP
cord-344093-3bniy5b5	364	14	that	that	IN
cord-344093-3bniy5b5	364	15	an	an	DT
cord-344093-3bniy5b5	364	16	exaggerated	exaggerated	JJ
cord-344093-3bniy5b5	364	17	signaling	signaling	NN
cord-344093-3bniy5b5	364	18	derived	derive	VBN
cord-344093-3bniy5b5	364	19	from	from	IN
cord-344093-3bniy5b5	364	20	type	type	NN
cord-344093-3bniy5b5	364	21	I	-PRON-	PRP
cord-344093-3bniy5b5	364	22	IFN	IFN	NNP
cord-344093-3bniy5b5	364	23	in	in	IN
cord-344093-3bniy5b5	364	24	an	an	DT
cord-344093-3bniy5b5	364	25	already	already	RB
cord-344093-3bniy5b5	364	26	inflamed	inflamed	JJ
cord-344093-3bniy5b5	364	27	tissue	tissue	NN
cord-344093-3bniy5b5	364	28	contributes	contribute	VBZ
cord-344093-3bniy5b5	364	29	to	to	IN
cord-344093-3bniy5b5	364	30	worsened	worsen	VBN
cord-344093-3bniy5b5	364	31	outcomes	outcome	NNS
cord-344093-3bniy5b5	364	32	,	,	,
cord-344093-3bniy5b5	364	33	and	and	CC
cord-344093-3bniy5b5	364	34	importantly	importantly	RB
cord-344093-3bniy5b5	364	35	,	,	,
cord-344093-3bniy5b5	364	36	might	may	MD
cord-344093-3bniy5b5	364	37	favor	favor	VB
cord-344093-3bniy5b5	364	38	secondary	secondary	JJ
cord-344093-3bniy5b5	364	39	bacterial	bacterial	JJ
cord-344093-3bniy5b5	364	40	superinfection	superinfection	NN
cord-344093-3bniy5b5	364	41	[	[	-LRB-
cord-344093-3bniy5b5	364	42	e.g.	e.g.	RB
cord-344093-3bniy5b5	364	43	,	,	,
cord-344093-3bniy5b5	364	44	Ref	Ref	NNP
cord-344093-3bniy5b5	364	45	.	.	.
cord-344093-3bniy5b5	365	1	(	(	-LRB-
cord-344093-3bniy5b5	365	2	75	75	CD
cord-344093-3bniy5b5	365	3	,	,	,
cord-344093-3bniy5b5	365	4	76	76	CD
cord-344093-3bniy5b5	365	5	,	,	,
cord-344093-3bniy5b5	365	6	209	209	CD
cord-344093-3bniy5b5	365	7	)	)	-RRB-
cord-344093-3bniy5b5	365	8	]	]	-RRB-
cord-344093-3bniy5b5	365	9	.	.	.
cord-344093-3bniy5b5	366	1	Interestingly	interestingly	RB
cord-344093-3bniy5b5	366	2	,	,	,
cord-344093-3bniy5b5	366	3	Davidson	Davidson	NNP
cord-344093-3bniy5b5	366	4	et	et	NNP
cord-344093-3bniy5b5	366	5	al	al	NNP
cord-344093-3bniy5b5	366	6	.	.	.
cord-344093-3bniy5b5	367	1	(	(	-LRB-
cord-344093-3bniy5b5	367	2	209	209	CD
cord-344093-3bniy5b5	367	3	)	)	-RRB-
cord-344093-3bniy5b5	367	4	demonstrated	demonstrate	VBD
cord-344093-3bniy5b5	367	5	that	that	DT
cord-344093-3bniy5b5	367	6	type	type	NN
cord-344093-3bniy5b5	367	7	III	III	NNP
cord-344093-3bniy5b5	367	8	IFN	IFN	NNP
cord-344093-3bniy5b5	367	9	release	release	NN
cord-344093-3bniy5b5	367	10	upon	upon	IN
cord-344093-3bniy5b5	367	11	influenza	influenza	NN
cord-344093-3bniy5b5	367	12	challenge	challenge	NN
cord-344093-3bniy5b5	367	13	-	-	HYPH
cord-344093-3bniy5b5	367	14	in	in	RP
cord-344093-3bniy5b5	367	15	contrast	contrast	NN
cord-344093-3bniy5b5	367	16	to	to	TO
cord-344093-3bniy5b5	367	17	type	type	NN
cord-344093-3bniy5b5	367	18	I	-PRON-	PRP
cord-344093-3bniy5b5	367	19	IFN	IFN	NNP
cord-344093-3bniy5b5	367	20	induction	induction	NN
cord-344093-3bniy5b5	367	21	-	-	:
cord-344093-3bniy5b5	367	22	does	do	VBZ
cord-344093-3bniy5b5	367	23	not	not	RB
cord-344093-3bniy5b5	367	24	trigger	trigger	VB
cord-344093-3bniy5b5	367	25	an	an	DT
cord-344093-3bniy5b5	367	26	unbalanced	unbalanced	JJ
cord-344093-3bniy5b5	367	27	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	367	28	response	response	NN
cord-344093-3bniy5b5	367	29	that	that	WDT
cord-344093-3bniy5b5	367	30	critically	critically	RB
cord-344093-3bniy5b5	367	31	contributes	contribute	VBZ
cord-344093-3bniy5b5	367	32	to	to	IN
cord-344093-3bniy5b5	367	33	respiratory	respiratory	JJ
cord-344093-3bniy5b5	367	34	disease	disease	NN
cord-344093-3bniy5b5	367	35	progression	progression	NN
cord-344093-3bniy5b5	367	36	in	in	IN
cord-344093-3bniy5b5	367	37	vivo	vivo	NN
cord-344093-3bniy5b5	367	38	,	,	,
cord-344093-3bniy5b5	367	39	highlighting	highlight	VBG
cord-344093-3bniy5b5	367	40	it	-PRON-	PRP
cord-344093-3bniy5b5	367	41	as	as	IN
cord-344093-3bniy5b5	367	42	a	a	DT
cord-344093-3bniy5b5	367	43	possible	possible	JJ
cord-344093-3bniy5b5	367	44	therapeutic	therapeutic	JJ
cord-344093-3bniy5b5	367	45	option	option	NN
cord-344093-3bniy5b5	367	46	in	in	IN
cord-344093-3bniy5b5	367	47	IAV	IAV	NNP
cord-344093-3bniy5b5	367	48	-	-	HYPH
cord-344093-3bniy5b5	367	49	induced	induce	VBN
cord-344093-3bniy5b5	367	50	lung	lung	NN
cord-344093-3bniy5b5	367	51	injury	injury	NN
cord-344093-3bniy5b5	367	52	.	.	.
cord-344093-3bniy5b5	368	1	Most	most	RBS
cord-344093-3bniy5b5	368	2	likely	likely	JJ
cord-344093-3bniy5b5	368	3	,	,	,
cord-344093-3bniy5b5	368	4	this	this	DT
cord-344093-3bniy5b5	368	5	effect	effect	NN
cord-344093-3bniy5b5	368	6	derives	derive	VBZ
cord-344093-3bniy5b5	368	7	from	from	IN
cord-344093-3bniy5b5	368	8	the	the	DT
cord-344093-3bniy5b5	368	9	lack	lack	NN
cord-344093-3bniy5b5	368	10	of	of	IN
cord-344093-3bniy5b5	368	11	the	the	DT
cord-344093-3bniy5b5	368	12	IFN	IFN	NNP
cord-344093-3bniy5b5	368	13	-	-	HYPH
cord-344093-3bniy5b5	368	14	λR1	λR1	NNP
cord-344093-3bniy5b5	368	15	/	/	SYM
cord-344093-3bniy5b5	368	16	IL-10R2	il-10r2	NN
cord-344093-3bniy5b5	368	17	receptor	receptor	NN
cord-344093-3bniy5b5	368	18	complex	complex	NN
cord-344093-3bniy5b5	368	19	,	,	,
cord-344093-3bniy5b5	368	20	but	but	CC
cord-344093-3bniy5b5	368	21	presence	presence	NN
cord-344093-3bniy5b5	368	22	of	of	IN
cord-344093-3bniy5b5	368	23	IFNAR	IFNAR	NNP
cord-344093-3bniy5b5	368	24	,	,	,
cord-344093-3bniy5b5	368	25	on	on	IN
cord-344093-3bniy5b5	368	26	immune	immune	JJ
cord-344093-3bniy5b5	368	27	cells	cell	NNS
cord-344093-3bniy5b5	368	28	,	,	,
cord-344093-3bniy5b5	368	29	including	include	VBG
cord-344093-3bniy5b5	368	30	bone	bone	NN
cord-344093-3bniy5b5	368	31	marrowderived	marrowderive	VBN
cord-344093-3bniy5b5	368	32	macrophages	macrophage	NNS
cord-344093-3bniy5b5	368	33	.	.	.
cord-344093-3bniy5b5	369	1	Nonetheless	nonetheless	RB
cord-344093-3bniy5b5	369	2	,	,	,
cord-344093-3bniy5b5	369	3	other	other	JJ
cord-344093-3bniy5b5	369	4	reports	report	NNS
cord-344093-3bniy5b5	369	5	identify	identify	VBP
cord-344093-3bniy5b5	369	6	IFN	IFN	NNP
cord-344093-3bniy5b5	369	7	-	-	HYPH
cord-344093-3bniy5b5	369	8	λ	λ	NNP
cord-344093-3bniy5b5	369	9	as	as	IN
cord-344093-3bniy5b5	369	10	a	a	DT
cord-344093-3bniy5b5	369	11	driver	driver	NN
cord-344093-3bniy5b5	369	12	of	of	IN
cord-344093-3bniy5b5	369	13	macrophage	macrophage	NN
cord-344093-3bniy5b5	369	14	polarization	polarization	NN
cord-344093-3bniy5b5	369	15	to	to	IN
cord-344093-3bniy5b5	369	16	an	an	DT
cord-344093-3bniy5b5	369	17	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	369	18	M1	M1	NNP
cord-344093-3bniy5b5	369	19	phenotype	phenotype	NN
cord-344093-3bniy5b5	369	20	(	(	-LRB-
cord-344093-3bniy5b5	369	21	41	41	CD
cord-344093-3bniy5b5	369	22	)	)	-RRB-
cord-344093-3bniy5b5	369	23	that	that	WDT
cord-344093-3bniy5b5	369	24	has	have	VBZ
cord-344093-3bniy5b5	369	25	been	be	VBN
cord-344093-3bniy5b5	369	26	attributed	attribute	VBN
cord-344093-3bniy5b5	369	27	to	to	TO
cord-344093-3bniy5b5	369	28	further	further	RB
cord-344093-3bniy5b5	369	29	promote	promote	VB
cord-344093-3bniy5b5	369	30	an	an	DT
cord-344093-3bniy5b5	369	31	overshooting	overshoot	VBG
cord-344093-3bniy5b5	369	32	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	369	33	response	response	NN
cord-344093-3bniy5b5	369	34	,	,	,
cord-344093-3bniy5b5	369	35	highlighting	highlight	VBG
cord-344093-3bniy5b5	369	36	the	the	DT
cord-344093-3bniy5b5	369	37	need	need	NN
cord-344093-3bniy5b5	369	38	for	for	IN
cord-344093-3bniy5b5	369	39	further	further	JJ
cord-344093-3bniy5b5	369	40	studies	study	NNS
cord-344093-3bniy5b5	369	41	of	of	IN
cord-344093-3bniy5b5	369	42	type	type	NN
cord-344093-3bniy5b5	369	43	III	III	NNP
cord-344093-3bniy5b5	369	44	IFN	IFN	NNP
cord-344093-3bniy5b5	369	45	biology	biology	NN
cord-344093-3bniy5b5	369	46	in	in	IN
cord-344093-3bniy5b5	369	47	pathogen	pathogen	NN
cord-344093-3bniy5b5	369	48	-	-	HYPH
cord-344093-3bniy5b5	369	49	associated	associate	VBN
cord-344093-3bniy5b5	369	50	disease	disease	NN
cord-344093-3bniy5b5	369	51	progression	progression	NN
cord-344093-3bniy5b5	369	52	.	.	.
cord-344093-3bniy5b5	370	1	As	as	IN
cord-344093-3bniy5b5	370	2	generally	generally	RB
cord-344093-3bniy5b5	370	3	IFN	IFN	NNP
cord-344093-3bniy5b5	370	4	-	-	HYPH
cord-344093-3bniy5b5	370	5	directed	direct	VBN
cord-344093-3bniy5b5	370	6	therapeutic	therapeutic	JJ
cord-344093-3bniy5b5	370	7	approaches	approach	NNS
cord-344093-3bniy5b5	370	8	target	target	VBP
cord-344093-3bniy5b5	370	9	various	various	JJ
cord-344093-3bniy5b5	370	10	downstream	downstream	NN
cord-344093-3bniy5b5	370	11	signaling	signal	VBG
cord-344093-3bniy5b5	370	12	events	event	NNS
cord-344093-3bniy5b5	370	13	that	that	WDT
cord-344093-3bniy5b5	370	14	might	may	MD
cord-344093-3bniy5b5	370	15	both	both	DT
cord-344093-3bniy5b5	370	16	act	act	VB
cord-344093-3bniy5b5	370	17	beneficially	beneficially	RB
cord-344093-3bniy5b5	370	18	as	as	RB
cord-344093-3bniy5b5	370	19	well	well	RB
cord-344093-3bniy5b5	370	20	as	as	IN
cord-344093-3bniy5b5	370	21	detrimentally	detrimentally	RB
cord-344093-3bniy5b5	370	22	on	on	IN
cord-344093-3bniy5b5	370	23	viral	viral	JJ
cord-344093-3bniy5b5	370	24	replication	replication	NN
cord-344093-3bniy5b5	370	25	and	and	CC
cord-344093-3bniy5b5	370	26	pathogenesis	pathogenesis	NN
cord-344093-3bniy5b5	370	27	,	,	,
cord-344093-3bniy5b5	370	28	a	a	DT
cord-344093-3bniy5b5	370	29	further	further	JJ
cord-344093-3bniy5b5	370	30	approach	approach	NN
cord-344093-3bniy5b5	370	31	is	be	VBZ
cord-344093-3bniy5b5	370	32	to	to	TO
cord-344093-3bniy5b5	370	33	address	address	VB
cord-344093-3bniy5b5	370	34	specific	specific	JJ
cord-344093-3bniy5b5	370	35	ISGs	isg	NNS
cord-344093-3bniy5b5	370	36	that	that	WDT
cord-344093-3bniy5b5	370	37	primarily	primarily	RB
cord-344093-3bniy5b5	370	38	show	show	VBP
cord-344093-3bniy5b5	370	39	detrimental	detrimental	JJ
cord-344093-3bniy5b5	370	40	effects	effect	NNS
cord-344093-3bniy5b5	370	41	on	on	IN
cord-344093-3bniy5b5	370	42	disease	disease	NN
cord-344093-3bniy5b5	370	43	progression	progression	NN
cord-344093-3bniy5b5	370	44	.	.	.
cord-344093-3bniy5b5	371	1	As	as	IN
cord-344093-3bniy5b5	371	2	outlined	outline	VBN
cord-344093-3bniy5b5	371	3	above	above	RB
cord-344093-3bniy5b5	371	4	,	,	,
cord-344093-3bniy5b5	371	5	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	371	6	or	or	CC
cord-344093-3bniy5b5	371	7	its	-PRON-	PRP$
cord-344093-3bniy5b5	371	8	downstream	downstream	JJ
cord-344093-3bniy5b5	371	9	signaling	signal	VBG
cord-344093-3bniy5b5	371	10	events	event	NNS
cord-344093-3bniy5b5	371	11	might	may	MD
cord-344093-3bniy5b5	371	12	comprise	comprise	VB
cord-344093-3bniy5b5	371	13	a	a	DT
cord-344093-3bniy5b5	371	14	suitable	suitable	JJ
cord-344093-3bniy5b5	371	15	target	target	NN
cord-344093-3bniy5b5	371	16	for	for	IN
cord-344093-3bniy5b5	371	17	adjunct	adjunct	JJ
cord-344093-3bniy5b5	371	18	therapies	therapy	NNS
cord-344093-3bniy5b5	371	19	in	in	IN
cord-344093-3bniy5b5	371	20	addition	addition	NN
cord-344093-3bniy5b5	371	21	to	to	IN
cord-344093-3bniy5b5	371	22	antivirals	antiviral	NNS
cord-344093-3bniy5b5	371	23	.	.	.
cord-344093-3bniy5b5	372	1	Accordingly	accordingly	RB
cord-344093-3bniy5b5	372	2	,	,	,
cord-344093-3bniy5b5	372	3	our	-PRON-	PRP$
cord-344093-3bniy5b5	372	4	own	own	JJ
cord-344093-3bniy5b5	372	5	data	datum	NNS
cord-344093-3bniy5b5	372	6	in	in	IN
cord-344093-3bniy5b5	372	7	a	a	DT
cord-344093-3bniy5b5	372	8	preclinical	preclinical	JJ
cord-344093-3bniy5b5	372	9	mouse	mouse	NN
cord-344093-3bniy5b5	372	10	model	model	NN
cord-344093-3bniy5b5	372	11	of	of	IN
cord-344093-3bniy5b5	372	12	IAV	IAV	NNP
cord-344093-3bniy5b5	372	13	infection	infection	NN
cord-344093-3bniy5b5	372	14	demonstrate	demonstrate	VBP
cord-344093-3bniy5b5	372	15	a	a	DT
cord-344093-3bniy5b5	372	16	clear	clear	JJ
cord-344093-3bniy5b5	372	17	benefit	benefit	NN
cord-344093-3bniy5b5	372	18	of	of	IN
cord-344093-3bniy5b5	372	19	the	the	DT
cord-344093-3bniy5b5	372	20	systemic	systemic	JJ
cord-344093-3bniy5b5	372	21	application	application	NN
cord-344093-3bniy5b5	372	22	of	of	IN
cord-344093-3bniy5b5	372	23	neutralizing	neutralize	VBG
cord-344093-3bniy5b5	372	24	antibodies	antibody	NNS
cord-344093-3bniy5b5	372	25	against	against	IN
cord-344093-3bniy5b5	372	26	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	372	27	at	at	IN
cord-344093-3bniy5b5	372	28	days	day	NNS
cord-344093-3bniy5b5	372	29	3	3	CD
cord-344093-3bniy5b5	372	30	and	and	CC
cord-344093-3bniy5b5	372	31	5	5	CD
cord-344093-3bniy5b5	372	32	postinfection	postinfection	NN
cord-344093-3bniy5b5	372	33	for	for	IN
cord-344093-3bniy5b5	372	34	lung	lung	NN
cord-344093-3bniy5b5	372	35	injury	injury	NN
cord-344093-3bniy5b5	372	36	,	,	,
cord-344093-3bniy5b5	372	37	morbidity	morbidity	NN
cord-344093-3bniy5b5	372	38	,	,	,
cord-344093-3bniy5b5	372	39	and	and	CC
cord-344093-3bniy5b5	372	40	mortality	mortality	NN
cord-344093-3bniy5b5	372	41	(	(	-LRB-
cord-344093-3bniy5b5	372	42	10	10	CD
cord-344093-3bniy5b5	372	43	,	,	,
cord-344093-3bniy5b5	372	44	11	11	CD
cord-344093-3bniy5b5	372	45	)	)	-RRB-
cord-344093-3bniy5b5	372	46	.	.	.
cord-344093-3bniy5b5	373	1	Targeting	target	VBG
cord-344093-3bniy5b5	373	2	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	373	3	as	as	IN
cord-344093-3bniy5b5	373	4	a	a	DT
cord-344093-3bniy5b5	373	5	major	major	JJ
cord-344093-3bniy5b5	373	6	determinant	determinant	NN
cord-344093-3bniy5b5	373	7	of	of	IN
cord-344093-3bniy5b5	373	8	disease	disease	NN
cord-344093-3bniy5b5	373	9	severity	severity	NN
cord-344093-3bniy5b5	373	10	in	in	IN
cord-344093-3bniy5b5	373	11	respiratory	respiratory	JJ
cord-344093-3bniy5b5	373	12	viral	viral	JJ
cord-344093-3bniy5b5	373	13	infections	infection	NNS
cord-344093-3bniy5b5	373	14	including	include	VBG
cord-344093-3bniy5b5	373	15	IAV	IAV	NNP
cord-344093-3bniy5b5	373	16	,	,	,
cord-344093-3bniy5b5	373	17	but	but	CC
cord-344093-3bniy5b5	373	18	also	also	RB
cord-344093-3bniy5b5	373	19	RSV	RSV	NNP
cord-344093-3bniy5b5	373	20	and	and	CC
cord-344093-3bniy5b5	373	21	CoV	CoV	NNP
cord-344093-3bniy5b5	373	22	,	,	,
cord-344093-3bniy5b5	373	23	may	may	MD
cord-344093-3bniy5b5	373	24	yield	yield	VB
cord-344093-3bniy5b5	373	25	therapeutic	therapeutic	JJ
cord-344093-3bniy5b5	373	26	approaches	approach	NNS
cord-344093-3bniy5b5	373	27	that	that	WDT
cord-344093-3bniy5b5	373	28	are	be	VBP
cord-344093-3bniy5b5	373	29	superior	superior	JJ
cord-344093-3bniy5b5	373	30	to	to	IN
cord-344093-3bniy5b5	373	31	IFN	IFN	NNP
cord-344093-3bniy5b5	373	32	-	-	HYPH
cord-344093-3bniy5b5	373	33	directed	direct	VBN
cord-344093-3bniy5b5	373	34	strategies	strategy	NNS
cord-344093-3bniy5b5	373	35	,	,	,
cord-344093-3bniy5b5	373	36	as	as	IN
cord-344093-3bniy5b5	373	37	they	-PRON-	PRP
cord-344093-3bniy5b5	373	38	seemingly	seemingly	RB
cord-344093-3bniy5b5	373	39	do	do	VBP
cord-344093-3bniy5b5	373	40	not	not	RB
cord-344093-3bniy5b5	373	41	bear	bear	VB
cord-344093-3bniy5b5	373	42	the	the	DT
cord-344093-3bniy5b5	373	43	risk	risk	NN
cord-344093-3bniy5b5	373	44	of	of	IN
cord-344093-3bniy5b5	373	45	compromising	compromise	VBG
cord-344093-3bniy5b5	373	46	host	host	NN
cord-344093-3bniy5b5	373	47	defense	defense	NN
cord-344093-3bniy5b5	373	48	.	.	.
cord-344093-3bniy5b5	374	1	Yet	yet	CC
cord-344093-3bniy5b5	374	2	,	,	,
cord-344093-3bniy5b5	374	3	it	-PRON-	PRP
cord-344093-3bniy5b5	374	4	should	should	MD
cord-344093-3bniy5b5	374	5	be	be	VB
cord-344093-3bniy5b5	374	6	thoroughly	thoroughly	RB
cord-344093-3bniy5b5	374	7	excluded	exclude	VBN
cord-344093-3bniy5b5	374	8	that	that	IN
cord-344093-3bniy5b5	374	9	blocking	block	VBG
cord-344093-3bniy5b5	374	10	TRAIL	trail	NN
cord-344093-3bniy5b5	374	11	-	-	HYPH
cord-344093-3bniy5b5	374	12	induced	induce	VBN
cord-344093-3bniy5b5	374	13	cell	cell	NN
cord-344093-3bniy5b5	374	14	death	death	NN
cord-344093-3bniy5b5	374	15	of	of	IN
cord-344093-3bniy5b5	374	16	infected	infected	JJ
cord-344093-3bniy5b5	374	17	cells	cell	NNS
cord-344093-3bniy5b5	374	18	will	will	MD
cord-344093-3bniy5b5	374	19	not	not	RB
cord-344093-3bniy5b5	374	20	lead	lead	VB
cord-344093-3bniy5b5	374	21	to	to	IN
cord-344093-3bniy5b5	374	22	an	an	DT
cord-344093-3bniy5b5	374	23	overwhelming	overwhelming	JJ
cord-344093-3bniy5b5	374	24	viral	viral	JJ
cord-344093-3bniy5b5	374	25	spreading	spreading	NN
cord-344093-3bniy5b5	374	26	,	,	,
cord-344093-3bniy5b5	374	27	especially	especially	RB
cord-344093-3bniy5b5	374	28	as	as	IN
cord-344093-3bniy5b5	374	29	reports	report	NNS
cord-344093-3bniy5b5	374	30	on	on	IN
cord-344093-3bniy5b5	374	31	viral	viral	JJ
cord-344093-3bniy5b5	374	32	loads	load	NNS
cord-344093-3bniy5b5	374	33	upon	upon	IN
cord-344093-3bniy5b5	374	34	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	374	35	inhibition	inhibition	NN
cord-344093-3bniy5b5	374	36	in	in	IN
cord-344093-3bniy5b5	374	37	preclinical	preclinical	JJ
cord-344093-3bniy5b5	374	38	models	model	NNS
cord-344093-3bniy5b5	374	39	of	of	IN
cord-344093-3bniy5b5	374	40	IAV	IAV	NNP
cord-344093-3bniy5b5	374	41	are	be	VBP
cord-344093-3bniy5b5	374	42	controversial	controversial	JJ
cord-344093-3bniy5b5	374	43	(	(	-LRB-
cord-344093-3bniy5b5	374	44	6	6	CD
cord-344093-3bniy5b5	374	45	,	,	,
cord-344093-3bniy5b5	374	46	10	10	CD
cord-344093-3bniy5b5	374	47	,	,	,
cord-344093-3bniy5b5	374	48	170	170	CD
cord-344093-3bniy5b5	374	49	)	)	-RRB-
cord-344093-3bniy5b5	374	50	.	.	.
cord-344093-3bniy5b5	375	1	Accordingly	accordingly	RB
cord-344093-3bniy5b5	375	2	,	,	,
cord-344093-3bniy5b5	375	3	additional	additional	JJ
cord-344093-3bniy5b5	375	4	studies	study	NNS
cord-344093-3bniy5b5	375	5	are	be	VBP
cord-344093-3bniy5b5	375	6	needed	need	VBN
cord-344093-3bniy5b5	375	7	to	to	TO
cord-344093-3bniy5b5	375	8	understand	understand	VB
cord-344093-3bniy5b5	375	9	how	how	WRB
cord-344093-3bniy5b5	375	10	and	and	CC
cord-344093-3bniy5b5	375	11	to	to	TO
cord-344093-3bniy5b5	375	12	which	which	WDT
cord-344093-3bniy5b5	375	13	extent	extent	NN
cord-344093-3bniy5b5	375	14	virus	virus	NN
cord-344093-3bniy5b5	375	15	-	-	HYPH
cord-344093-3bniy5b5	375	16	infected	infect	VBN
cord-344093-3bniy5b5	375	17	cells	cell	NNS
cord-344093-3bniy5b5	375	18	can	can	MD
cord-344093-3bniy5b5	375	19	be	be	VB
cord-344093-3bniy5b5	375	20	killed	kill	VBN
cord-344093-3bniy5b5	375	21	or	or	CC
cord-344093-3bniy5b5	375	22	viral	viral	JJ
cord-344093-3bniy5b5	375	23	spreading	spreading	NN
cord-344093-3bniy5b5	375	24	can	can	MD
cord-344093-3bniy5b5	375	25	be	be	VB
cord-344093-3bniy5b5	375	26	controlled	control	VBN
cord-344093-3bniy5b5	375	27	by	by	IN
cord-344093-3bniy5b5	375	28	other	other	JJ
cord-344093-3bniy5b5	375	29	means	mean	NNS
cord-344093-3bniy5b5	375	30	in	in	IN
cord-344093-3bniy5b5	375	31	the	the	DT
cord-344093-3bniy5b5	375	32	absence	absence	NN
cord-344093-3bniy5b5	375	33	of	of	IN
cord-344093-3bniy5b5	375	34	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	375	35	.	.	.
cord-344093-3bniy5b5	376	1	Moreover	moreover	RB
cord-344093-3bniy5b5	376	2	,	,	,
cord-344093-3bniy5b5	376	3	targeting	target	VBG
cord-344093-3bniy5b5	376	4	pathways	pathway	NNS
cord-344093-3bniy5b5	376	5	and	and	CC
cord-344093-3bniy5b5	376	6	signaling	signal	VBG
cord-344093-3bniy5b5	376	7	hubs	hub	NNS
cord-344093-3bniy5b5	376	8	downstream	downstream	RB
cord-344093-3bniy5b5	376	9	of	of	IN
cord-344093-3bniy5b5	376	10	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	376	11	/	/	SYM
cord-344093-3bniy5b5	376	12	DRs	DRs	NNPS
cord-344093-3bniy5b5	376	13	,	,	,
cord-344093-3bniy5b5	376	14	such	such	JJ
cord-344093-3bniy5b5	376	15	as	as	IN
cord-344093-3bniy5b5	376	16	AMPK	AMPK	NNP
cord-344093-3bniy5b5	376	17	(	(	-LRB-
cord-344093-3bniy5b5	376	18	11	11	CD
cord-344093-3bniy5b5	376	19	)	)	-RRB-
cord-344093-3bniy5b5	376	20	,	,	,
cord-344093-3bniy5b5	376	21	in	in	IN
cord-344093-3bniy5b5	376	22	a	a	DT
cord-344093-3bniy5b5	376	23	well	well	RB
cord-344093-3bniy5b5	376	24	-	-	HYPH
cord-344093-3bniy5b5	376	25	timed	time	VBN
cord-344093-3bniy5b5	376	26	and	and	CC
cord-344093-3bniy5b5	376	27	lung	lung	NN
cord-344093-3bniy5b5	376	28	compartment	compartment	NN
cord-344093-3bniy5b5	376	29	-	-	HYPH
cord-344093-3bniy5b5	376	30	specific	specific	JJ
cord-344093-3bniy5b5	376	31	way	way	NN
cord-344093-3bniy5b5	376	32	,	,	,
cord-344093-3bniy5b5	376	33	may	may	MD
cord-344093-3bniy5b5	376	34	open	open	VB
cord-344093-3bniy5b5	376	35	new	new	JJ
cord-344093-3bniy5b5	376	36	therapeutic	therapeutic	JJ
cord-344093-3bniy5b5	376	37	avenues	avenue	NNS
cord-344093-3bniy5b5	376	38	but	but	CC
cord-344093-3bniy5b5	376	39	requires	require	VBZ
cord-344093-3bniy5b5	376	40	more	more	RBR
cord-344093-3bniy5b5	376	41	detailed	detailed	JJ
cord-344093-3bniy5b5	376	42	preclinical	preclinical	JJ
cord-344093-3bniy5b5	376	43	studies	study	NNS
cord-344093-3bniy5b5	376	44	on	on	IN
cord-344093-3bniy5b5	376	45	efficacies	efficacy	NNS
cord-344093-3bniy5b5	376	46	and	and	CC
cord-344093-3bniy5b5	376	47	side	side	NN
cord-344093-3bniy5b5	376	48	effects	effect	NNS
cord-344093-3bniy5b5	376	49	.	.	.
cord-344093-3bniy5b5	377	1	A	a	DT
cord-344093-3bniy5b5	377	2	valid	valid	JJ
cord-344093-3bniy5b5	377	3	approach	approach	NN
cord-344093-3bniy5b5	377	4	might	may	MD
cord-344093-3bniy5b5	377	5	be	be	VB
cord-344093-3bniy5b5	377	6	the	the	DT
cord-344093-3bniy5b5	377	7	use	use	NN
cord-344093-3bniy5b5	377	8	of	of	IN
cord-344093-3bniy5b5	377	9	a	a	DT
cord-344093-3bniy5b5	377	10	combination	combination	NN
cord-344093-3bniy5b5	377	11	therapy	therapy	NN
cord-344093-3bniy5b5	377	12	of	of	IN
cord-344093-3bniy5b5	377	13	such	such	PDT
cord-344093-3bniy5b5	377	14	a	a	DT
cord-344093-3bniy5b5	377	15	treatment	treatment	NN
cord-344093-3bniy5b5	377	16	together	together	RB
cord-344093-3bniy5b5	377	17	with	with	IN
cord-344093-3bniy5b5	377	18	a	a	DT
cord-344093-3bniy5b5	377	19	classical	classical	JJ
cord-344093-3bniy5b5	377	20	antiviral	antiviral	JJ
cord-344093-3bniy5b5	377	21	drug	drug	NN
cord-344093-3bniy5b5	377	22	therapy	therapy	NN
cord-344093-3bniy5b5	377	23	limiting	limit	VBG
cord-344093-3bniy5b5	377	24	viral	viral	JJ
cord-344093-3bniy5b5	377	25	replication	replication	NN
cord-344093-3bniy5b5	377	26	;	;	:
cord-344093-3bniy5b5	377	27	however	however	RB
cord-344093-3bniy5b5	377	28	,	,	,
cord-344093-3bniy5b5	377	29	exact	exact	JJ
cord-344093-3bniy5b5	377	30	dosage	dosage	NN
cord-344093-3bniy5b5	377	31	,	,	,
cord-344093-3bniy5b5	377	32	timing	timing	NN
cord-344093-3bniy5b5	377	33	,	,	,
cord-344093-3bniy5b5	377	34	kinetics	kinetics	NN
cord-344093-3bniy5b5	377	35	,	,	,
cord-344093-3bniy5b5	377	36	and	and	CC
cord-344093-3bniy5b5	377	37	application	application	NN
cord-344093-3bniy5b5	377	38	routes	route	NNS
cord-344093-3bniy5b5	377	39	remain	remain	VBP
cord-344093-3bniy5b5	377	40	to	to	TO
cord-344093-3bniy5b5	377	41	be	be	VB
cord-344093-3bniy5b5	377	42	defined	define	VBN
cord-344093-3bniy5b5	377	43	.	.	.
cord-344093-3bniy5b5	378	1	CP	CP	NNP
cord-344093-3bniy5b5	378	2	and	and	CC
cord-344093-3bniy5b5	378	3	SH	SH	NNP
cord-344093-3bniy5b5	378	4	performed	perform	VBD
cord-344093-3bniy5b5	378	5	bibliographic	bibliographic	JJ
cord-344093-3bniy5b5	378	6	research	research	NN
cord-344093-3bniy5b5	378	7	and	and	CC
cord-344093-3bniy5b5	378	8	drafted	draft	VBD
cord-344093-3bniy5b5	378	9	the	the	DT
cord-344093-3bniy5b5	378	10	manuscript	manuscript	NN
cord-344093-3bniy5b5	378	11	.	.	.
cord-344093-3bniy5b5	379	1	This	this	DT
cord-344093-3bniy5b5	379	2	work	work	NN
cord-344093-3bniy5b5	379	3	was	be	VBD
cord-344093-3bniy5b5	379	4	supported	support	VBN
cord-344093-3bniy5b5	379	5	by	by	IN
cord-344093-3bniy5b5	379	6	the	the	DT
cord-344093-3bniy5b5	379	7	German	German	NNP
cord-344093-3bniy5b5	379	8	Research	Research	NNP
cord-344093-3bniy5b5	379	9	Foundation	Foundation	NNP
cord-344093-3bniy5b5	379	10	(	(	-LRB-
cord-344093-3bniy5b5	379	11	SFB	SFB	NNP
cord-344093-3bniy5b5	379	12	-	-	HYPH
cord-344093-3bniy5b5	379	13	TR84	TR84	NNP
cord-344093-3bniy5b5	379	14	B2	b2	NN
cord-344093-3bniy5b5	379	15	,	,	,
cord-344093-3bniy5b5	379	16	SFB1021	SFB1021	NNP
cord-344093-3bniy5b5	379	17	C05	C05	NNP
cord-344093-3bniy5b5	379	18	,	,	,
cord-344093-3bniy5b5	379	19	KFO309	KFO309	NNP
cord-344093-3bniy5b5	379	20	P2	P2	NNP
cord-344093-3bniy5b5	379	21	/	/	SYM
cord-344093-3bniy5b5	379	22	P8	P8	NNP
cord-344093-3bniy5b5	379	23	,	,	,
cord-344093-3bniy5b5	379	24	EXC147	EXC147	NNP
cord-344093-3bniy5b5	379	25	)	)	-RRB-
cord-344093-3bniy5b5	379	26	,	,	,
cord-344093-3bniy5b5	379	27	by	by	IN
cord-344093-3bniy5b5	379	28	the	the	DT
cord-344093-3bniy5b5	379	29	German	German	NNP
cord-344093-3bniy5b5	379	30	Center	Center	NNP
cord-344093-3bniy5b5	379	31	for	for	IN
cord-344093-3bniy5b5	379	32	Lung	Lung	NNP
cord-344093-3bniy5b5	379	33	Research	Research	NNP
cord-344093-3bniy5b5	379	34	(	(	-LRB-
cord-344093-3bniy5b5	379	35	DZL	DZL	NNP
cord-344093-3bniy5b5	379	36	)	)	-RRB-
cord-344093-3bniy5b5	379	37	,	,	,
cord-344093-3bniy5b5	379	38	and	and	CC
cord-344093-3bniy5b5	379	39	by	by	IN
cord-344093-3bniy5b5	379	40	the	the	DT
cord-344093-3bniy5b5	379	41	German	German	NNP
cord-344093-3bniy5b5	379	42	Center	Center	NNP
cord-344093-3bniy5b5	379	43	for	for	IN
cord-344093-3bniy5b5	379	44	Infection	Infection	NNP
cord-344093-3bniy5b5	379	45	Research	Research	NNP
cord-344093-3bniy5b5	379	46	(	(	-LRB-
cord-344093-3bniy5b5	379	47	DZIF	DZIF	NNP
cord-344093-3bniy5b5	379	48	)	)	-RRB-
cord-344093-3bniy5b5	379	49	.	.	.
cord-344093-3bniy5b5	380	1	Virus	virus	NN
cord-344093-3bniy5b5	380	2	interference	interference	NN
cord-344093-3bniy5b5	380	3	.	.	.
cord-344093-3bniy5b5	381	1	I.	I.	NNP
cord-344093-3bniy5b5	382	1	The	the	DT
cord-344093-3bniy5b5	382	2	interferon	interferon	NN
cord-344093-3bniy5b5	382	3	Regulation	regulation	NN
cord-344093-3bniy5b5	382	4	of	of	IN
cord-344093-3bniy5b5	382	5	interferon	interferon	NN
cord-344093-3bniy5b5	382	6	-	-	HYPH
cord-344093-3bniy5b5	382	7	γ	γ	NN
cord-344093-3bniy5b5	382	8	during	during	IN
cord-344093-3bniy5b5	382	9	innate	innate	JJ
cord-344093-3bniy5b5	382	10	and	and	CC
cord-344093-3bniy5b5	382	11	adaptive	adaptive	JJ
cord-344093-3bniy5b5	382	12	immune	immune	JJ
cord-344093-3bniy5b5	382	13	responses	response	NNS
cord-344093-3bniy5b5	382	14	Role	role	NN
cord-344093-3bniy5b5	382	15	of	of	IN
cord-344093-3bniy5b5	382	16	interferon	interferon	NN
cord-344093-3bniy5b5	382	17	-	-	HYPH
cord-344093-3bniy5b5	382	18	gamma	gamma	NN
cord-344093-3bniy5b5	382	19	in	in	IN
cord-344093-3bniy5b5	382	20	immune	immune	JJ
cord-344093-3bniy5b5	382	21	cell	cell	NN
cord-344093-3bniy5b5	382	22	regulation	regulation	NN
cord-344093-3bniy5b5	383	1	Alpha	alpha	NN
cord-344093-3bniy5b5	383	2	/	/	SYM
cord-344093-3bniy5b5	383	3	beta	beta	NN
cord-344093-3bniy5b5	383	4	interferons	interferon	NNS
cord-344093-3bniy5b5	383	5	potentiate	potentiate	VBP
cord-344093-3bniy5b5	383	6	virus	virus	NN
cord-344093-3bniy5b5	383	7	-	-	HYPH
cord-344093-3bniy5b5	383	8	induced	induce	VBN
cord-344093-3bniy5b5	383	9	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	383	10	through	through	IN
cord-344093-3bniy5b5	383	11	activation	activation	NN
cord-344093-3bniy5b5	383	12	of	of	IN
cord-344093-3bniy5b5	383	13	the	the	DT
cord-344093-3bniy5b5	383	14	FADD	FADD	NNP
cord-344093-3bniy5b5	383	15	/	/	SYM
cord-344093-3bniy5b5	383	16	caspase-8	caspase-8	NNP
cord-344093-3bniy5b5	383	17	death	death	NN
cord-344093-3bniy5b5	383	18	signaling	signal	VBG
cord-344093-3bniy5b5	383	19	pathway	pathway	NN
cord-344093-3bniy5b5	383	20	Lung	Lung	NNP
cord-344093-3bniy5b5	383	21	epithelial	epithelial	JJ
cord-344093-3bniy5b5	383	22	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	383	23	in	in	IN
cord-344093-3bniy5b5	383	24	influenza	influenza	NN
cord-344093-3bniy5b5	383	25	virus	virus	NN
cord-344093-3bniy5b5	383	26	pneumonia	pneumonia	NN
cord-344093-3bniy5b5	383	27	:	:	:
cord-344093-3bniy5b5	383	28	the	the	DT
cord-344093-3bniy5b5	383	29	role	role	NN
cord-344093-3bniy5b5	383	30	of	of	IN
cord-344093-3bniy5b5	383	31	macrophage	macrophage	NN
cord-344093-3bniy5b5	383	32	-	-	HYPH
cord-344093-3bniy5b5	383	33	expressed	express	VBN
cord-344093-3bniy5b5	383	34	TNF	tnf	NN
cord-344093-3bniy5b5	383	35	-	-	HYPH
cord-344093-3bniy5b5	383	36	related	relate	VBN
cord-344093-3bniy5b5	383	37	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	383	38	-	-	HYPH
cord-344093-3bniy5b5	383	39	inducing	induce	VBG
cord-344093-3bniy5b5	383	40	ligand	ligand	NN
cord-344093-3bniy5b5	383	41	CD8	CD8	NNP
cord-344093-3bniy5b5	383	42	T	T	NNP
cord-344093-3bniy5b5	383	43	cells	cell	NNS
cord-344093-3bniy5b5	383	44	utilize	utilize	VBP
cord-344093-3bniy5b5	383	45	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	383	46	to	to	TO
cord-344093-3bniy5b5	383	47	control	control	VB
cord-344093-3bniy5b5	383	48	influenza	influenza	NN
cord-344093-3bniy5b5	383	49	virus	virus	NN
cord-344093-3bniy5b5	383	50	infection	infection	NN
cord-344093-3bniy5b5	383	51	TRAIL+	TRAIL+	NNP
cord-344093-3bniy5b5	383	52	monocytes	monocyte	NNS
cord-344093-3bniy5b5	383	53	and	and	CC
cord-344093-3bniy5b5	384	1	monocyte	monocyte	NNP
cord-344093-3bniy5b5	384	2	-	-	HYPH
cord-344093-3bniy5b5	384	3	related	relate	VBN
cord-344093-3bniy5b5	384	4	cells	cell	NNS
cord-344093-3bniy5b5	384	5	cause	cause	VBP
cord-344093-3bniy5b5	384	6	lung	lung	NN
cord-344093-3bniy5b5	384	7	damage	damage	NN
cord-344093-3bniy5b5	384	8	and	and	CC
cord-344093-3bniy5b5	384	9	thereby	thereby	RB
cord-344093-3bniy5b5	384	10	increase	increase	VB
cord-344093-3bniy5b5	384	11	susceptibility	susceptibility	NN
cord-344093-3bniy5b5	384	12	to	to	IN
cord-344093-3bniy5b5	384	13	influenza	influenza	NN
cord-344093-3bniy5b5	384	14	-	-	HYPH
cord-344093-3bniy5b5	384	15	Streptococcus	streptococcus	NN
cord-344093-3bniy5b5	384	16	pneumoniae	pneumoniae	NN
cord-344093-3bniy5b5	384	17	coinfection	coinfection	VBP
cord-344093-3bniy5b5	384	18	TNF	TNF	NNP
cord-344093-3bniy5b5	384	19	-	-	HYPH
cord-344093-3bniy5b5	384	20	related	relate	VBN
cord-344093-3bniy5b5	384	21	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	384	22	-	-	HYPH
cord-344093-3bniy5b5	384	23	inducing	induce	VBG
cord-344093-3bniy5b5	384	24	ligand	ligand	NN
cord-344093-3bniy5b5	384	25	(	(	-LRB-
cord-344093-3bniy5b5	384	26	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	384	27	)	)	-RRB-
cord-344093-3bniy5b5	384	28	induces	induce	VBZ
cord-344093-3bniy5b5	384	29	neuronal	neuronal	JJ
cord-344093-3bniy5b5	384	30	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	384	31	in	in	IN
cord-344093-3bniy5b5	384	32	HIV	HIV	NNP
cord-344093-3bniy5b5	384	33	-	-	HYPH
cord-344093-3bniy5b5	384	34	encephalopathy	encephalopathy	NN
cord-344093-3bniy5b5	384	35	CD4	CD4	NNP
cord-344093-3bniy5b5	384	36	+	+	CC
cord-344093-3bniy5b5	384	37	T	t	NN
cord-344093-3bniy5b5	384	38	-	-	HYPH
cord-344093-3bniy5b5	384	39	cell	cell	NN
cord-344093-3bniy5b5	384	40	death	death	NN
cord-344093-3bniy5b5	384	41	induced	induce	VBN
cord-344093-3bniy5b5	384	42	by	by	IN
cord-344093-3bniy5b5	384	43	infectious	infectious	JJ
cord-344093-3bniy5b5	384	44	and	and	CC
cord-344093-3bniy5b5	384	45	noninfectious	noninfectious	JJ
cord-344093-3bniy5b5	384	46	HIV-1	HIV-1	NNP
cord-344093-3bniy5b5	384	47	:	:	:
cord-344093-3bniy5b5	385	1	role	role	NN
cord-344093-3bniy5b5	385	2	of	of	IN
cord-344093-3bniy5b5	385	3	type	type	NN
cord-344093-3bniy5b5	385	4	1	1	CD
cord-344093-3bniy5b5	385	5	interferon	interferon	NN
cord-344093-3bniy5b5	385	6	-	-	HYPH
cord-344093-3bniy5b5	385	7	dependent	dependent	JJ
cord-344093-3bniy5b5	385	8	,	,	,
cord-344093-3bniy5b5	385	9	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	385	10	/	/	SYM
cord-344093-3bniy5b5	385	11	DR5-mediated	dr5-mediate	VBD
cord-344093-3bniy5b5	385	12	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	385	13	Macrophage	macrophage	NN
cord-344093-3bniy5b5	385	14	-	-	HYPH
cord-344093-3bniy5b5	385	15	expressed	express	VBN
cord-344093-3bniy5b5	385	16	IFN	IFN	NNP
cord-344093-3bniy5b5	385	17	-	-	HYPH
cord-344093-3bniy5b5	385	18	β	β	NNP
cord-344093-3bniy5b5	385	19	contributes	contribute	VBZ
cord-344093-3bniy5b5	385	20	to	to	IN
cord-344093-3bniy5b5	385	21	apoptotic	apoptotic	JJ
cord-344093-3bniy5b5	385	22	alveolar	alveolar	JJ
cord-344093-3bniy5b5	385	23	epithelial	epithelial	JJ
cord-344093-3bniy5b5	385	24	cell	cell	NN
cord-344093-3bniy5b5	385	25	injury	injury	NN
cord-344093-3bniy5b5	385	26	in	in	IN
cord-344093-3bniy5b5	385	27	severe	severe	JJ
cord-344093-3bniy5b5	385	28	influenza	influenza	NN
cord-344093-3bniy5b5	385	29	virus	virus	NN
cord-344093-3bniy5b5	385	30	pneumonia	pneumonia	NN
cord-344093-3bniy5b5	385	31	Macrophage	macrophage	NN
cord-344093-3bniy5b5	385	32	-	-	HYPH
cord-344093-3bniy5b5	385	33	epithelial	epithelial	JJ
cord-344093-3bniy5b5	385	34	paracrine	paracrine	JJ
cord-344093-3bniy5b5	385	35	crosstalk	crosstalk	NN
cord-344093-3bniy5b5	386	1	inhibits	inhibit	VBZ
cord-344093-3bniy5b5	386	2	lung	lung	NN
cord-344093-3bniy5b5	386	3	edema	edema	NN
cord-344093-3bniy5b5	386	4	clearance	clearance	NN
cord-344093-3bniy5b5	386	5	during	during	IN
cord-344093-3bniy5b5	386	6	influenza	influenza	NN
cord-344093-3bniy5b5	386	7	infection	infection	NN
cord-344093-3bniy5b5	386	8	Approaching	approach	VBG
cord-344093-3bniy5b5	386	9	the	the	DT
cord-344093-3bniy5b5	386	10	asymptote	asymptote	NN
cord-344093-3bniy5b5	386	11	?	?	.
cord-344093-3bniy5b5	387	1	Evolution	evolution	NN
cord-344093-3bniy5b5	387	2	and	and	CC
cord-344093-3bniy5b5	387	3	revolution	revolution	NN
cord-344093-3bniy5b5	387	4	in	in	IN
cord-344093-3bniy5b5	387	5	immunology	immunology	NN
cord-344093-3bniy5b5	387	6	Sweeten	Sweeten	NNP
cord-344093-3bniy5b5	387	7	PAMPs	pamp	NNS
cord-344093-3bniy5b5	387	8	:	:	:
cord-344093-3bniy5b5	387	9	role	role	NN
cord-344093-3bniy5b5	387	10	of	of	IN
cord-344093-3bniy5b5	387	11	sugar	sugar	NN
cord-344093-3bniy5b5	387	12	complexed	complexed	JJ
cord-344093-3bniy5b5	387	13	PAMPs	pamp	NNS
cord-344093-3bniy5b5	387	14	in	in	IN
cord-344093-3bniy5b5	387	15	innate	innate	JJ
cord-344093-3bniy5b5	387	16	immunity	immunity	NN
cord-344093-3bniy5b5	387	17	and	and	CC
cord-344093-3bniy5b5	387	18	vaccine	vaccine	NN
cord-344093-3bniy5b5	387	19	biology	biology	NN
cord-344093-3bniy5b5	387	20	Pathogen	Pathogen	NNP
cord-344093-3bniy5b5	387	21	recognition	recognition	NN
cord-344093-3bniy5b5	387	22	and	and	CC
cord-344093-3bniy5b5	387	23	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	387	24	signaling	signaling	NN
cord-344093-3bniy5b5	387	25	in	in	IN
cord-344093-3bniy5b5	387	26	innate	innate	JJ
cord-344093-3bniy5b5	387	27	immune	immune	JJ
cord-344093-3bniy5b5	387	28	defenses	defense	NNS
cord-344093-3bniy5b5	388	1	Molecular	molecular	JJ
cord-344093-3bniy5b5	388	2	mechanisms	mechanism	NNS
cord-344093-3bniy5b5	388	3	of	of	IN
cord-344093-3bniy5b5	388	4	regulation	regulation	NN
cord-344093-3bniy5b5	388	5	of	of	IN
cord-344093-3bniy5b5	388	6	toll	toll	NN
cord-344093-3bniy5b5	388	7	-	-	HYPH
cord-344093-3bniy5b5	388	8	like	like	JJ
cord-344093-3bniy5b5	388	9	receptor	receptor	NN
cord-344093-3bniy5b5	388	10	signaling	signal	VBG
cord-344093-3bniy5b5	388	11	TAK1	TAK1	NNP
cord-344093-3bniy5b5	388	12	is	be	VBZ
cord-344093-3bniy5b5	388	13	a	a	DT
cord-344093-3bniy5b5	388	14	ubiquitin	ubiquitin	NN
cord-344093-3bniy5b5	388	15	-	-	HYPH
cord-344093-3bniy5b5	388	16	dependent	dependent	JJ
cord-344093-3bniy5b5	388	17	kinase	kinase	NN
cord-344093-3bniy5b5	388	18	of	of	IN
cord-344093-3bniy5b5	388	19	MKK	MKK	NNP
cord-344093-3bniy5b5	388	20	and	and	CC
cord-344093-3bniy5b5	388	21	IKK	IKK	NNP
cord-344093-3bniy5b5	389	1	The	the	DT
cord-344093-3bniy5b5	389	2	NF	NF	NNP
cord-344093-3bniy5b5	389	3	-	-	HYPH
cord-344093-3bniy5b5	389	4	kappaB	kappaB	NNP
cord-344093-3bniy5b5	389	5	family	family	NN
cord-344093-3bniy5b5	389	6	of	of	IN
cord-344093-3bniy5b5	389	7	transcription	transcription	NN
cord-344093-3bniy5b5	389	8	factors	factor	NNS
cord-344093-3bniy5b5	389	9	and	and	CC
cord-344093-3bniy5b5	389	10	its	-PRON-	PRP$
cord-344093-3bniy5b5	389	11	regulation	regulation	NN
cord-344093-3bniy5b5	389	12	Mechanisms	Mechanisms	NNPS
cord-344093-3bniy5b5	389	13	of	of	IN
cord-344093-3bniy5b5	389	14	RIG	rig	NN
cord-344093-3bniy5b5	389	15	-	-	HYPH
cord-344093-3bniy5b5	389	16	I	i	NN
cord-344093-3bniy5b5	389	17	-	-	HYPH
cord-344093-3bniy5b5	389	18	like	like	JJ
cord-344093-3bniy5b5	389	19	receptor	receptor	NN
cord-344093-3bniy5b5	389	20	activation	activation	NN
cord-344093-3bniy5b5	389	21	and	and	CC
cord-344093-3bniy5b5	389	22	manipulation	manipulation	NN
cord-344093-3bniy5b5	389	23	by	by	IN
cord-344093-3bniy5b5	389	24	viral	viral	JJ
cord-344093-3bniy5b5	389	25	pathogens	pathogen	NNS
cord-344093-3bniy5b5	389	26	RIG	rig	NN
cord-344093-3bniy5b5	389	27	-	-	:
cord-344093-3bniy5b5	389	28	I	-PRON-	PRP
cord-344093-3bniy5b5	389	29	in	in	IN
cord-344093-3bniy5b5	389	30	RNA	RNA	NNP
cord-344093-3bniy5b5	389	31	virus	virus	NN
cord-344093-3bniy5b5	389	32	recognition	recognition	NN
cord-344093-3bniy5b5	389	33	MDA-5	MDA-5	NNP
cord-344093-3bniy5b5	389	34	:	:	:
cord-344093-3bniy5b5	389	35	an	an	DT
cord-344093-3bniy5b5	389	36	interferon	interferon	NN
cord-344093-3bniy5b5	389	37	-	-	HYPH
cord-344093-3bniy5b5	389	38	inducible	inducible	JJ
cord-344093-3bniy5b5	389	39	putative	putative	JJ
cord-344093-3bniy5b5	389	40	RNA	RNA	NNP
cord-344093-3bniy5b5	389	41	helicase	helicase	NN
cord-344093-3bniy5b5	389	42	with	with	IN
cord-344093-3bniy5b5	389	43	double	double	RB
cord-344093-3bniy5b5	389	44	-	-	HYPH
cord-344093-3bniy5b5	389	45	stranded	strand	VBN
cord-344093-3bniy5b5	389	46	RNA	rna	NN
cord-344093-3bniy5b5	389	47	-	-	HYPH
cord-344093-3bniy5b5	389	48	dependent	dependent	JJ
cord-344093-3bniy5b5	389	49	ATPase	ATPase	NNP
cord-344093-3bniy5b5	389	50	activity	activity	NN
cord-344093-3bniy5b5	389	51	and	and	CC
cord-344093-3bniy5b5	389	52	melanoma	melanoma	NN
cord-344093-3bniy5b5	389	53	growth	growth	NN
cord-344093-3bniy5b5	389	54	-	-	HYPH
cord-344093-3bniy5b5	389	55	suppressive	suppressive	JJ
cord-344093-3bniy5b5	389	56	properties	property	NNS
cord-344093-3bniy5b5	389	57	Structure	Structure	NNP
cord-344093-3bniy5b5	389	58	of	of	IN
cord-344093-3bniy5b5	389	59	the	the	DT
cord-344093-3bniy5b5	389	60	mouse	mouse	NN
cord-344093-3bniy5b5	389	61	Stat	Stat	NNP
cord-344093-3bniy5b5	389	62	3/5	3/5	CD
cord-344093-3bniy5b5	389	63	Locus	locus	NN
cord-344093-3bniy5b5	389	64	:	:	:
cord-344093-3bniy5b5	389	65	evolution	evolution	NN
cord-344093-3bniy5b5	389	66	from	from	IN
cord-344093-3bniy5b5	389	67	Drosophila	Drosophila	NNP
cord-344093-3bniy5b5	389	68	to	to	IN
cord-344093-3bniy5b5	389	69	zebrafish	zebrafish	NN
cord-344093-3bniy5b5	389	70	to	to	TO
cord-344093-3bniy5b5	389	71	mouse	mouse	VB
cord-344093-3bniy5b5	389	72	IPS-1	IPS-1	NNP
cord-344093-3bniy5b5	389	73	,	,	,
cord-344093-3bniy5b5	389	74	an	an	DT
cord-344093-3bniy5b5	389	75	adaptor	adaptor	NN
cord-344093-3bniy5b5	389	76	triggering	trigger	VBG
cord-344093-3bniy5b5	389	77	RIG	rig	NN
cord-344093-3bniy5b5	389	78	-	-	HYPH
cord-344093-3bniy5b5	389	79	I	i	NN
cord-344093-3bniy5b5	389	80	-	-	HYPH
cord-344093-3bniy5b5	389	81	and	and	CC
cord-344093-3bniy5b5	389	82	MDA5-mediated	MDA5-mediated	NNP
cord-344093-3bniy5b5	389	83	type	type	NN
cord-344093-3bniy5b5	389	84	I	-PRON-	PRP
cord-344093-3bniy5b5	390	1	interferon	interferon	NNP
cord-344093-3bniy5b5	390	2	induction	induction	NN
cord-344093-3bniy5b5	390	3	RIG	RIG	NNP
cord-344093-3bniy5b5	390	4	-	-	HYPH
cord-344093-3bniy5b5	390	5	I	i	NN
cord-344093-3bniy5b5	390	6	-	-	HYPH
cord-344093-3bniy5b5	390	7	like	like	JJ
cord-344093-3bniy5b5	390	8	receptors	receptor	NNS
cord-344093-3bniy5b5	390	9	control	control	VBP
cord-344093-3bniy5b5	390	10	unique	unique	JJ
cord-344093-3bniy5b5	390	11	innate	innate	JJ
cord-344093-3bniy5b5	390	12	immune	immune	JJ
cord-344093-3bniy5b5	390	13	responses	response	NNS
cord-344093-3bniy5b5	390	14	following	follow	VBG
cord-344093-3bniy5b5	390	15	West	West	NNP
cord-344093-3bniy5b5	390	16	Nile	Nile	NNP
cord-344093-3bniy5b5	390	17	virus	virus	NN
cord-344093-3bniy5b5	390	18	infection	infection	NN
cord-344093-3bniy5b5	390	19	NOD	nod	NN
cord-344093-3bniy5b5	390	20	-	-	HYPH
cord-344093-3bniy5b5	390	21	like	like	JJ
cord-344093-3bniy5b5	390	22	receptors	receptor	NNS
cord-344093-3bniy5b5	390	23	in	in	IN
cord-344093-3bniy5b5	390	24	lung	lung	NN
cord-344093-3bniy5b5	390	25	diseases	disease	NNS
cord-344093-3bniy5b5	391	1	HCV	HCV	NNP
cord-344093-3bniy5b5	391	2	genomic	genomic	JJ
cord-344093-3bniy5b5	391	3	RNA	RNA	NNP
cord-344093-3bniy5b5	391	4	activates	activate	VBZ
cord-344093-3bniy5b5	391	5	the	the	DT
cord-344093-3bniy5b5	391	6	NLRP3	nlrp3	XX
cord-344093-3bniy5b5	391	7	inflammasome	inflammasome	NNP
cord-344093-3bniy5b5	391	8	in	in	IN
cord-344093-3bniy5b5	391	9	human	human	JJ
cord-344093-3bniy5b5	391	10	myeloid	myeloid	NN
cord-344093-3bniy5b5	391	11	cells	cell	NNS
cord-344093-3bniy5b5	392	1	Measles	measles	NN
cord-344093-3bniy5b5	392	2	virus	virus	NN
cord-344093-3bniy5b5	392	3	V	v	NN
cord-344093-3bniy5b5	392	4	protein	protein	NN
cord-344093-3bniy5b5	392	5	inhibits	inhibit	VBZ
cord-344093-3bniy5b5	392	6	NLRP3	nlrp3	XX
cord-344093-3bniy5b5	393	1	inflammasome	inflammasome	NNP
cord-344093-3bniy5b5	393	2	-	-	HYPH
cord-344093-3bniy5b5	393	3	mediated	mediate	VBN
cord-344093-3bniy5b5	393	4	interleukin-1	interleukin-1	NNP
cord-344093-3bniy5b5	393	5	secretion	secretion	NN
cord-344093-3bniy5b5	393	6	Influenza	Influenza	NNP
cord-344093-3bniy5b5	393	7	virus	virus	NN
cord-344093-3bniy5b5	393	8	activates	activate	VBZ
cord-344093-3bniy5b5	393	9	inflammasomes	inflammasome	NNS
cord-344093-3bniy5b5	393	10	via	via	IN
cord-344093-3bniy5b5	393	11	its	-PRON-	PRP$
cord-344093-3bniy5b5	393	12	intracellular	intracellular	JJ
cord-344093-3bniy5b5	393	13	M2	M2	NNP
cord-344093-3bniy5b5	393	14	ion	ion	NN
cord-344093-3bniy5b5	393	15	channel	channel	NN
cord-344093-3bniy5b5	394	1	The	the	DT
cord-344093-3bniy5b5	394	2	NLRP3	nlrp3	NN
cord-344093-3bniy5b5	394	3	inflammasome	inflammasome	NNP
cord-344093-3bniy5b5	394	4	detects	detect	VBZ
cord-344093-3bniy5b5	394	5	encephalomyocarditis	encephalomyocarditis	NNP
cord-344093-3bniy5b5	394	6	virus	virus	NN
cord-344093-3bniy5b5	394	7	and	and	CC
cord-344093-3bniy5b5	394	8	vesicular	vesicular	JJ
cord-344093-3bniy5b5	394	9	stomatitis	stomatitis	NN
cord-344093-3bniy5b5	394	10	virus	virus	NN
cord-344093-3bniy5b5	394	11	infection	infection	NN
cord-344093-3bniy5b5	395	1	The	the	DT
cord-344093-3bniy5b5	395	2	NLRP3	nlrp3	NN
cord-344093-3bniy5b5	395	3	inflammasome	inflammasome	NN
cord-344093-3bniy5b5	395	4	mediates	mediate	VBZ
cord-344093-3bniy5b5	395	5	in	in	IN
cord-344093-3bniy5b5	395	6	vivo	vivo	FW
cord-344093-3bniy5b5	395	7	innate	innate	JJ
cord-344093-3bniy5b5	395	8	immunity	immunity	NN
cord-344093-3bniy5b5	395	9	to	to	TO
cord-344093-3bniy5b5	395	10	influenza	influenza	NN
cord-344093-3bniy5b5	395	11	A	a	DT
cord-344093-3bniy5b5	395	12	virus	virus	NN
cord-344093-3bniy5b5	395	13	through	through	IN
cord-344093-3bniy5b5	395	14	recognition	recognition	NN
cord-344093-3bniy5b5	395	15	of	of	IN
cord-344093-3bniy5b5	395	16	viral	viral	JJ
cord-344093-3bniy5b5	395	17	RNA	RNA	NNP
cord-344093-3bniy5b5	395	18	Rabies	Rabies	NNP
cord-344093-3bniy5b5	395	19	virus	virus	NN
cord-344093-3bniy5b5	395	20	is	be	VBZ
cord-344093-3bniy5b5	395	21	recognized	recognize	VBN
cord-344093-3bniy5b5	395	22	by	by	IN
cord-344093-3bniy5b5	395	23	the	the	DT
cord-344093-3bniy5b5	395	24	NLRP3	NLRP3	NNP
cord-344093-3bniy5b5	395	25	inflammasome	inflammasome	NNP
cord-344093-3bniy5b5	395	26	and	and	CC
cord-344093-3bniy5b5	395	27	activates	activate	VBZ
cord-344093-3bniy5b5	395	28	interleukin-1β	interleukin-1β	NNP
cord-344093-3bniy5b5	395	29	release	release	NN
cord-344093-3bniy5b5	395	30	in	in	IN
cord-344093-3bniy5b5	395	31	murine	murine	JJ
cord-344093-3bniy5b5	395	32	dendritic	dendritic	JJ
cord-344093-3bniy5b5	395	33	cells	cell	NNS
cord-344093-3bniy5b5	395	34	Inflammasomes	inflammasome	NNS
cord-344093-3bniy5b5	395	35	and	and	CC
cord-344093-3bniy5b5	395	36	viruses	virus	NNS
cord-344093-3bniy5b5	395	37	:	:	:
cord-344093-3bniy5b5	395	38	cellular	cellular	JJ
cord-344093-3bniy5b5	395	39	defence	defence	NN
cord-344093-3bniy5b5	395	40	versus	versus	IN
cord-344093-3bniy5b5	395	41	viral	viral	JJ
cord-344093-3bniy5b5	395	42	offence	offence	NN
cord-344093-3bniy5b5	396	1	Innate	innate	JJ
cord-344093-3bniy5b5	397	1	immune	immune	JJ
cord-344093-3bniy5b5	397	2	sensing	sensing	NN
cord-344093-3bniy5b5	397	3	and	and	CC
cord-344093-3bniy5b5	397	4	signaling	signaling	NN
cord-344093-3bniy5b5	397	5	of	of	IN
cord-344093-3bniy5b5	397	6	cytosolic	cytosolic	JJ
cord-344093-3bniy5b5	397	7	nucleic	nucleic	JJ
cord-344093-3bniy5b5	397	8	acids	acid	NNS
cord-344093-3bniy5b5	397	9	Serum	serum	NN
cord-344093-3bniy5b5	397	10	levels	level	NNS
cord-344093-3bniy5b5	397	11	of	of	IN
cord-344093-3bniy5b5	397	12	tumor	tumor	NN
cord-344093-3bniy5b5	397	13	necrosis	necrosis	NN
cord-344093-3bniy5b5	397	14	factor	factor	NN
cord-344093-3bniy5b5	397	15	-	-	HYPH
cord-344093-3bniy5b5	397	16	related	relate	VBN
cord-344093-3bniy5b5	397	17	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	397	18	-	-	HYPH
cord-344093-3bniy5b5	397	19	inducing	induce	VBG
cord-344093-3bniy5b5	397	20	ligand	ligand	NN
cord-344093-3bniy5b5	397	21	correlate	correlate	VBP
cord-344093-3bniy5b5	397	22	with	with	IN
cord-344093-3bniy5b5	397	23	the	the	DT
cord-344093-3bniy5b5	397	24	severity	severity	NN
cord-344093-3bniy5b5	397	25	of	of	IN
cord-344093-3bniy5b5	397	26	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	397	27	hypertension	hypertension	NN
cord-344093-3bniy5b5	397	28	Phosphorylation	Phosphorylation	NNP
cord-344093-3bniy5b5	397	29	of	of	IN
cord-344093-3bniy5b5	397	30	innate	innate	JJ
cord-344093-3bniy5b5	397	31	immune	immune	JJ
cord-344093-3bniy5b5	397	32	adaptor	adaptor	NN
cord-344093-3bniy5b5	397	33	proteins	protein	NNS
cord-344093-3bniy5b5	397	34	MAVS	mavs	RB
cord-344093-3bniy5b5	397	35	,	,	,
cord-344093-3bniy5b5	397	36	STING	sting	NN
cord-344093-3bniy5b5	397	37	,	,	,
cord-344093-3bniy5b5	397	38	and	and	CC
cord-344093-3bniy5b5	397	39	TRIF	TRIF	NNP
cord-344093-3bniy5b5	398	1	induces	induce	VBZ
cord-344093-3bniy5b5	398	2	IRF3	IRF3	NNP
cord-344093-3bniy5b5	398	3	activation	activation	NN
cord-344093-3bniy5b5	398	4	Cytosolic	Cytosolic	NNP
cord-344093-3bniy5b5	398	5	RNA	RNA	NNP
cord-344093-3bniy5b5	398	6	:	:	:
cord-344093-3bniy5b5	399	1	DNA	dna	NN
cord-344093-3bniy5b5	399	2	hybrids	hybrid	NNS
cord-344093-3bniy5b5	399	3	activate	activate	VBP
cord-344093-3bniy5b5	399	4	the	the	DT
cord-344093-3bniy5b5	399	5	cGAS	cgas	JJ
cord-344093-3bniy5b5	399	6	-	-	HYPH
cord-344093-3bniy5b5	399	7	STING	sting	NN
cord-344093-3bniy5b5	399	8	axis	axis	NN
cord-344093-3bniy5b5	399	9	RIG	rig	NN
cord-344093-3bniy5b5	399	10	-	-	:
cord-344093-3bniy5b5	399	11	I	-PRON-	PRP
cord-344093-3bniy5b5	399	12	mediated	mediate	VBD
cord-344093-3bniy5b5	399	13	STING	sting	NN
cord-344093-3bniy5b5	399	14	up	up	IN
cord-344093-3bniy5b5	399	15	-	-	HYPH
cord-344093-3bniy5b5	399	16	regulation	regulation	NN
cord-344093-3bniy5b5	399	17	restricts	restrict	VBZ
cord-344093-3bniy5b5	399	18	HSV-1	hsv-1	NN
cord-344093-3bniy5b5	399	19	infection	infection	NN
cord-344093-3bniy5b5	399	20	MITA	MITA	NNP
cord-344093-3bniy5b5	399	21	/	/	SYM
cord-344093-3bniy5b5	399	22	STING	STING	NNP
cord-344093-3bniy5b5	399	23	:	:	:
cord-344093-3bniy5b5	399	24	a	a	DT
cord-344093-3bniy5b5	399	25	central	central	JJ
cord-344093-3bniy5b5	399	26	and	and	CC
cord-344093-3bniy5b5	399	27	multifaceted	multifaceted	JJ
cord-344093-3bniy5b5	399	28	mediator	mediator	NN
cord-344093-3bniy5b5	399	29	in	in	IN
cord-344093-3bniy5b5	399	30	innate	innate	JJ
cord-344093-3bniy5b5	399	31	immune	immune	JJ
cord-344093-3bniy5b5	399	32	response	response	NN
cord-344093-3bniy5b5	400	1	Protein	protein	NN
cord-344093-3bniy5b5	400	2	kinase	kinase	VBZ
cord-344093-3bniy5b5	400	3	PKR	PKR	NNP
cord-344093-3bniy5b5	400	4	amplification	amplification	NN
cord-344093-3bniy5b5	400	5	of	of	IN
cord-344093-3bniy5b5	400	6	interferon	interferon	NN
cord-344093-3bniy5b5	400	7	β	β	NNP
cord-344093-3bniy5b5	400	8	induction	induction	NN
cord-344093-3bniy5b5	400	9	occurs	occur	VBZ
cord-344093-3bniy5b5	400	10	through	through	IN
cord-344093-3bniy5b5	400	11	initiation	initiation	NN
cord-344093-3bniy5b5	400	12	factor	factor	NN
cord-344093-3bniy5b5	400	13	eIF-2α	eIF-2α	NNS
cord-344093-3bniy5b5	400	14	-	-	HYPH
cord-344093-3bniy5b5	400	15	mediated	mediate	VBN
cord-344093-3bniy5b5	400	16	translational	translational	JJ
cord-344093-3bniy5b5	400	17	control	control	NN
cord-344093-3bniy5b5	400	18	Poly(I	Poly(I	NNP
cord-344093-3bniy5b5	400	19	-	-	HYPH
cord-344093-3bniy5b5	400	20	C)-induced	C)-induced	NNP
cord-344093-3bniy5b5	400	21	toll	toll	NN
cord-344093-3bniy5b5	400	22	-	-	HYPH
cord-344093-3bniy5b5	400	23	like	like	JJ
cord-344093-3bniy5b5	400	24	receptor	receptor	NN
cord-344093-3bniy5b5	400	25	3	3	CD
cord-344093-3bniy5b5	400	26	(	(	-LRB-
cord-344093-3bniy5b5	400	27	TLR3)-mediated	tlr3)-mediate	VBN
cord-344093-3bniy5b5	400	28	activation	activation	NN
cord-344093-3bniy5b5	400	29	of	of	IN
cord-344093-3bniy5b5	400	30	NFkappa	NFkappa	NNP
cord-344093-3bniy5b5	400	31	B	B	NNP
cord-344093-3bniy5b5	400	32	and	and	CC
cord-344093-3bniy5b5	400	33	MAP	MAP	NNP
cord-344093-3bniy5b5	400	34	kinase	kinase	NN
cord-344093-3bniy5b5	400	35	is	be	VBZ
cord-344093-3bniy5b5	400	36	through	through	IN
cord-344093-3bniy5b5	400	37	an	an	DT
cord-344093-3bniy5b5	400	38	interleukin-1	interleukin-1	NNP
cord-344093-3bniy5b5	400	39	receptor	receptor	NN
cord-344093-3bniy5b5	400	40	-	-	HYPH
cord-344093-3bniy5b5	400	41	associated	associate	VBN
cord-344093-3bniy5b5	400	42	kinase	kinase	NN
cord-344093-3bniy5b5	400	43	(	(	-LRB-
cord-344093-3bniy5b5	400	44	IRAK)-independent	IRAK)-independent	NNP
cord-344093-3bniy5b5	400	45	pathway	pathway	NN
cord-344093-3bniy5b5	400	46	employing	employ	VBG
cord-344093-3bniy5b5	400	47	the	the	DT
cord-344093-3bniy5b5	400	48	signaling	signal	VBG
cord-344093-3bniy5b5	400	49	components	component	NNS
cord-344093-3bniy5b5	401	1	TLR3-TRAF6-TAK1-TAB	TLR3-TRAF6-TAK1-TAB	NNP
cord-344093-3bniy5b5	401	2	2-PKR	2-pkr	CD
cord-344093-3bniy5b5	402	1	IRF-1	IRF-1	NNP
cord-344093-3bniy5b5	402	2	induced	induce	VBD
cord-344093-3bniy5b5	402	3	cell	cell	NN
cord-344093-3bniy5b5	402	4	growth	growth	NN
cord-344093-3bniy5b5	402	5	inhibition	inhibition	NN
cord-344093-3bniy5b5	402	6	and	and	CC
cord-344093-3bniy5b5	402	7	interferon	interferon	NN
cord-344093-3bniy5b5	402	8	induction	induction	NN
cord-344093-3bniy5b5	402	9	requires	require	VBZ
cord-344093-3bniy5b5	402	10	the	the	DT
cord-344093-3bniy5b5	402	11	activity	activity	NN
cord-344093-3bniy5b5	402	12	of	of	IN
cord-344093-3bniy5b5	402	13	the	the	DT
cord-344093-3bniy5b5	402	14	protein	protein	NN
cord-344093-3bniy5b5	402	15	kinase	kinase	VBZ
cord-344093-3bniy5b5	402	16	PKR	PKR	NNP
cord-344093-3bniy5b5	403	1	The	the	DT
cord-344093-3bniy5b5	403	2	impact	impact	NN
cord-344093-3bniy5b5	403	3	of	of	IN
cord-344093-3bniy5b5	403	4	the	the	DT
cord-344093-3bniy5b5	403	5	interferon	interferon	NN
cord-344093-3bniy5b5	403	6	-	-	HYPH
cord-344093-3bniy5b5	403	7	lambda	lambda	NN
cord-344093-3bniy5b5	403	8	family	family	NN
cord-344093-3bniy5b5	403	9	on	on	IN
cord-344093-3bniy5b5	403	10	the	the	DT
cord-344093-3bniy5b5	403	11	innate	innate	JJ
cord-344093-3bniy5b5	403	12	and	and	CC
cord-344093-3bniy5b5	403	13	adaptive	adaptive	JJ
cord-344093-3bniy5b5	403	14	immune	immune	JJ
cord-344093-3bniy5b5	403	15	response	response	NN
cord-344093-3bniy5b5	403	16	to	to	IN
cord-344093-3bniy5b5	403	17	viral	viral	JJ
cord-344093-3bniy5b5	403	18	infections	infection	NNS
cord-344093-3bniy5b5	404	1	The	the	DT
cord-344093-3bniy5b5	404	2	unique	unique	JJ
cord-344093-3bniy5b5	404	3	regulation	regulation	NN
cord-344093-3bniy5b5	404	4	and	and	CC
cord-344093-3bniy5b5	404	5	functions	function	NNS
cord-344093-3bniy5b5	404	6	of	of	IN
cord-344093-3bniy5b5	404	7	type	type	NN
cord-344093-3bniy5b5	404	8	III	iii	CD
cord-344093-3bniy5b5	404	9	interferons	interferon	NNS
cord-344093-3bniy5b5	404	10	in	in	IN
cord-344093-3bniy5b5	404	11	antiviral	antiviral	JJ
cord-344093-3bniy5b5	404	12	immunity	immunity	NN
cord-344093-3bniy5b5	404	13	Diverse	diverse	JJ
cord-344093-3bniy5b5	404	14	intracellular	intracellular	JJ
cord-344093-3bniy5b5	404	15	pathogens	pathogen	NNS
cord-344093-3bniy5b5	404	16	activate	activate	VBP
cord-344093-3bniy5b5	404	17	type	type	NN
cord-344093-3bniy5b5	404	18	III	iii	CD
cord-344093-3bniy5b5	404	19	interferon	interferon	NN
cord-344093-3bniy5b5	404	20	expression	expression	NN
cord-344093-3bniy5b5	404	21	from	from	IN
cord-344093-3bniy5b5	404	22	peroxisomes	peroxisome	NNS
cord-344093-3bniy5b5	404	23	Teleost	Teleost	NNP
cord-344093-3bniy5b5	404	24	fish	fish	NN
cord-344093-3bniy5b5	404	25	interferons	interferon	NNS
cord-344093-3bniy5b5	404	26	and	and	CC
cord-344093-3bniy5b5	404	27	their	-PRON-	PRP$
cord-344093-3bniy5b5	404	28	role	role	NN
cord-344093-3bniy5b5	404	29	in	in	IN
cord-344093-3bniy5b5	404	30	immunity	immunity	NN
cord-344093-3bniy5b5	405	1	The	the	DT
cord-344093-3bniy5b5	405	2	evolution	evolution	NN
cord-344093-3bniy5b5	405	3	of	of	IN
cord-344093-3bniy5b5	405	4	antiviral	antiviral	JJ
cord-344093-3bniy5b5	405	5	defense	defense	NN
cord-344093-3bniy5b5	405	6	systems	system	NNS
cord-344093-3bniy5b5	406	1	Interferon	interferon	NN
cord-344093-3bniy5b5	406	2	-	-	HYPH
cord-344093-3bniy5b5	406	3	stimulated	stimulate	VBN
cord-344093-3bniy5b5	406	4	genes	gene	NNS
cord-344093-3bniy5b5	406	5	:	:	:
cord-344093-3bniy5b5	406	6	a	a	DT
cord-344093-3bniy5b5	406	7	complex	complex	JJ
cord-344093-3bniy5b5	406	8	web	web	NN
cord-344093-3bniy5b5	406	9	of	of	IN
cord-344093-3bniy5b5	406	10	host	host	NN
cord-344093-3bniy5b5	406	11	defenses	defense	NNS
cord-344093-3bniy5b5	407	1	Fluorescenceactivated	fluorescenceactivated	JJ
cord-344093-3bniy5b5	407	2	cell	cell	NN
cord-344093-3bniy5b5	407	3	sorting	sorting	NN
cord-344093-3bniy5b5	407	4	-	-	HYPH
cord-344093-3bniy5b5	407	5	based	base	VBN
cord-344093-3bniy5b5	407	6	analysis	analysis	NN
cord-344093-3bniy5b5	407	7	reveals	reveal	VBZ
cord-344093-3bniy5b5	407	8	an	an	DT
cord-344093-3bniy5b5	407	9	asymmetric	asymmetric	JJ
cord-344093-3bniy5b5	407	10	induction	induction	NN
cord-344093-3bniy5b5	407	11	of	of	IN
cord-344093-3bniy5b5	407	12	interferon	interferon	NN
cord-344093-3bniy5b5	407	13	-	-	HYPH
cord-344093-3bniy5b5	407	14	stimulated	stimulate	VBN
cord-344093-3bniy5b5	407	15	genes	gene	NNS
cord-344093-3bniy5b5	407	16	in	in	IN
cord-344093-3bniy5b5	407	17	response	response	NN
cord-344093-3bniy5b5	407	18	to	to	IN
cord-344093-3bniy5b5	407	19	seasonal	seasonal	JJ
cord-344093-3bniy5b5	407	20	influenza	influenza	NN
cord-344093-3bniy5b5	407	21	A	a	DT
cord-344093-3bniy5b5	407	22	virus	virus	NN
cord-344093-3bniy5b5	407	23	IFN	IFN	NNP
cord-344093-3bniy5b5	407	24	-	-	HYPH
cord-344093-3bniy5b5	407	25	lambda	lambda	NNP
cord-344093-3bniy5b5	407	26	(	(	-LRB-
cord-344093-3bniy5b5	407	27	IFN	IFN	NNP
cord-344093-3bniy5b5	407	28	-	-	HYPH
cord-344093-3bniy5b5	407	29	λ	λ	NNP
cord-344093-3bniy5b5	407	30	)	)	-RRB-
cord-344093-3bniy5b5	407	31	is	be	VBZ
cord-344093-3bniy5b5	407	32	expressed	express	VBN
cord-344093-3bniy5b5	407	33	in	in	IN
cord-344093-3bniy5b5	407	34	a	a	DT
cord-344093-3bniy5b5	407	35	tissue	tissue	NN
cord-344093-3bniy5b5	407	36	-	-	HYPH
cord-344093-3bniy5b5	407	37	dependent	dependent	JJ
cord-344093-3bniy5b5	407	38	fashion	fashion	NN
cord-344093-3bniy5b5	407	39	and	and	CC
cord-344093-3bniy5b5	407	40	primarily	primarily	RB
cord-344093-3bniy5b5	407	41	acts	act	VBZ
cord-344093-3bniy5b5	407	42	on	on	IN
cord-344093-3bniy5b5	407	43	epithelial	epithelial	JJ
cord-344093-3bniy5b5	407	44	cells	cell	NNS
cord-344093-3bniy5b5	407	45	in	in	IN
cord-344093-3bniy5b5	407	46	vivo	vivo	NNP
cord-344093-3bniy5b5	407	47	Type	type	NN
cord-344093-3bniy5b5	407	48	III	III	NNP
cord-344093-3bniy5b5	407	49	interferon	interferon	NN
cord-344093-3bniy5b5	407	50	(	(	-LRB-
cord-344093-3bniy5b5	407	51	IFN	IFN	NNP
cord-344093-3bniy5b5	407	52	)	)	-RRB-
cord-344093-3bniy5b5	407	53	induces	induce	VBZ
cord-344093-3bniy5b5	407	54	a	a	DT
cord-344093-3bniy5b5	407	55	type	type	NN
cord-344093-3bniy5b5	407	56	I	-PRON-	PRP
cord-344093-3bniy5b5	407	57	IFN	IFN	NNP
cord-344093-3bniy5b5	407	58	-	-	HYPH
cord-344093-3bniy5b5	407	59	like	like	JJ
cord-344093-3bniy5b5	407	60	response	response	NN
cord-344093-3bniy5b5	407	61	in	in	IN
cord-344093-3bniy5b5	407	62	a	a	DT
cord-344093-3bniy5b5	407	63	restricted	restrict	VBN
cord-344093-3bniy5b5	407	64	subset	subset	NN
cord-344093-3bniy5b5	407	65	of	of	IN
cord-344093-3bniy5b5	407	66	cells	cell	NNS
cord-344093-3bniy5b5	407	67	through	through	IN
cord-344093-3bniy5b5	407	68	signaling	signal	VBG
cord-344093-3bniy5b5	407	69	pathways	pathway	NNS
cord-344093-3bniy5b5	407	70	involving	involve	VBG
cord-344093-3bniy5b5	407	71	both	both	CC
cord-344093-3bniy5b5	407	72	the	the	DT
cord-344093-3bniy5b5	407	73	Jak	Jak	NNP
cord-344093-3bniy5b5	407	74	-	-	HYPH
cord-344093-3bniy5b5	407	75	STAT	STAT	NNP
cord-344093-3bniy5b5	407	76	pathway	pathway	NN
cord-344093-3bniy5b5	407	77	and	and	CC
cord-344093-3bniy5b5	408	1	the	the	DT
cord-344093-3bniy5b5	408	2	mitogen	mitogen	NNP
cord-344093-3bniy5b5	408	3	-	-	HYPH
cord-344093-3bniy5b5	408	4	activated	activate	VBN
cord-344093-3bniy5b5	408	5	protein	protein	NN
cord-344093-3bniy5b5	408	6	kinases	kinase	NNS
cord-344093-3bniy5b5	408	7	The	the	DT
cord-344093-3bniy5b5	408	8	IFITM	IFITM	NNP
cord-344093-3bniy5b5	408	9	proteins	protein	NNS
cord-344093-3bniy5b5	408	10	mediate	mediate	VBP
cord-344093-3bniy5b5	408	11	cellular	cellular	JJ
cord-344093-3bniy5b5	408	12	resistance	resistance	NN
cord-344093-3bniy5b5	408	13	to	to	TO
cord-344093-3bniy5b5	408	14	influenza	influenza	VB
cord-344093-3bniy5b5	408	15	A	a	DT
cord-344093-3bniy5b5	408	16	H1N1	H1N1	NNP
cord-344093-3bniy5b5	408	17	virus	virus	NN
cord-344093-3bniy5b5	408	18	,	,	,
cord-344093-3bniy5b5	408	19	West	West	NNP
cord-344093-3bniy5b5	408	20	Nile	Nile	NNP
cord-344093-3bniy5b5	408	21	virus	virus	NN
cord-344093-3bniy5b5	408	22	,	,	,
cord-344093-3bniy5b5	408	23	and	and	CC
cord-344093-3bniy5b5	408	24	dengue	dengue	NN
cord-344093-3bniy5b5	408	25	virus	virus	NN
cord-344093-3bniy5b5	409	1	The	the	DT
cord-344093-3bniy5b5	409	2	interferon	interferon	NN
cord-344093-3bniy5b5	409	3	-	-	HYPH
cord-344093-3bniy5b5	409	4	stimulated	stimulate	VBN
cord-344093-3bniy5b5	409	5	gene	gene	NN
cord-344093-3bniy5b5	409	6	Ifitm3	Ifitm3	NNP
cord-344093-3bniy5b5	409	7	restricts	restrict	VBZ
cord-344093-3bniy5b5	409	8	West	West	NNP
cord-344093-3bniy5b5	409	9	Nile	Nile	NNP
cord-344093-3bniy5b5	409	10	virus	virus	NN
cord-344093-3bniy5b5	409	11	infection	infection	NN
cord-344093-3bniy5b5	409	12	and	and	CC
cord-344093-3bniy5b5	409	13	pathogenesis	pathogenesis	NN
cord-344093-3bniy5b5	409	14	Inhibition	inhibition	NN
cord-344093-3bniy5b5	409	15	of	of	IN
cord-344093-3bniy5b5	409	16	vesicular	vesicular	JJ
cord-344093-3bniy5b5	409	17	stomatitis	stomatitis	NN
cord-344093-3bniy5b5	409	18	virus	virus	NN
cord-344093-3bniy5b5	410	1	mRNA	mRNA	NNP
cord-344093-3bniy5b5	410	2	synthesis	synthesis	NN
cord-344093-3bniy5b5	410	3	by	by	IN
cord-344093-3bniy5b5	410	4	human	human	JJ
cord-344093-3bniy5b5	410	5	MxA	MxA	NNP
cord-344093-3bniy5b5	410	6	protein	protein	NN
cord-344093-3bniy5b5	410	7	Myxovirus	Myxovirus	NNP
cord-344093-3bniy5b5	410	8	resistance	resistance	NN
cord-344093-3bniy5b5	410	9	gene	gene	NN
cord-344093-3bniy5b5	410	10	A	a	NN
cord-344093-3bniy5b5	410	11	(	(	-LRB-
cord-344093-3bniy5b5	410	12	MxA	mxa	NN
cord-344093-3bniy5b5	410	13	)	)	-RRB-
cord-344093-3bniy5b5	410	14	expression	expression	NN
cord-344093-3bniy5b5	410	15	suppresses	suppress	VBZ
cord-344093-3bniy5b5	410	16	influenza	influenza	NN
cord-344093-3bniy5b5	410	17	A	a	DT
cord-344093-3bniy5b5	410	18	virus	virus	NN
cord-344093-3bniy5b5	410	19	replication	replication	NN
cord-344093-3bniy5b5	410	20	in	in	IN
cord-344093-3bniy5b5	410	21	alpha	alpha	NN
cord-344093-3bniy5b5	410	22	interferon	interferon	NN
cord-344093-3bniy5b5	410	23	-	-	HYPH
cord-344093-3bniy5b5	410	24	treated	treat	VBN
cord-344093-3bniy5b5	410	25	primate	primate	NN
cord-344093-3bniy5b5	410	26	cells	cell	NNS
cord-344093-3bniy5b5	411	1	The	the	DT
cord-344093-3bniy5b5	411	2	human	human	JJ
cord-344093-3bniy5b5	411	3	interferon	interferon	NN
cord-344093-3bniy5b5	411	4	-	-	HYPH
cord-344093-3bniy5b5	411	5	induced	induce	VBN
cord-344093-3bniy5b5	411	6	MxA	mxa	NN
cord-344093-3bniy5b5	411	7	protein	protein	NN
cord-344093-3bniy5b5	411	8	inhibits	inhibit	VBZ
cord-344093-3bniy5b5	411	9	early	early	JJ
cord-344093-3bniy5b5	411	10	stages	stage	NNS
cord-344093-3bniy5b5	411	11	of	of	IN
cord-344093-3bniy5b5	411	12	influenza	influenza	NN
cord-344093-3bniy5b5	411	13	A	a	DT
cord-344093-3bniy5b5	411	14	virus	virus	NN
cord-344093-3bniy5b5	411	15	infection	infection	NN
cord-344093-3bniy5b5	411	16	by	by	IN
cord-344093-3bniy5b5	411	17	retaining	retain	VBG
cord-344093-3bniy5b5	411	18	the	the	DT
cord-344093-3bniy5b5	411	19	incoming	incoming	JJ
cord-344093-3bniy5b5	411	20	viral	viral	JJ
cord-344093-3bniy5b5	411	21	genome	genome	NN
cord-344093-3bniy5b5	411	22	in	in	IN
cord-344093-3bniy5b5	411	23	the	the	DT
cord-344093-3bniy5b5	411	24	cytoplasm	cytoplasm	NN
cord-344093-3bniy5b5	412	1	Innate	innate	JJ
cord-344093-3bniy5b5	412	2	immunity	immunity	NN
cord-344093-3bniy5b5	412	3	to	to	IN
cord-344093-3bniy5b5	412	4	influenza	influenza	NN
cord-344093-3bniy5b5	412	5	virus	virus	NN
cord-344093-3bniy5b5	412	6	infection	infection	NN
cord-344093-3bniy5b5	412	7	A	a	DT
cord-344093-3bniy5b5	412	8	serpin	serpin	NN
cord-344093-3bniy5b5	412	9	shapes	shape	VBZ
cord-344093-3bniy5b5	412	10	the	the	DT
cord-344093-3bniy5b5	412	11	extracellular	extracellular	JJ
cord-344093-3bniy5b5	412	12	environment	environment	NN
cord-344093-3bniy5b5	412	13	to	to	TO
cord-344093-3bniy5b5	412	14	prevent	prevent	VB
cord-344093-3bniy5b5	412	15	influenza	influenza	NN
cord-344093-3bniy5b5	412	16	A	a	DT
cord-344093-3bniy5b5	412	17	virus	virus	NN
cord-344093-3bniy5b5	412	18	maturation	maturation	NN
cord-344093-3bniy5b5	412	19	Influenza	Influenza	NNP
cord-344093-3bniy5b5	412	20	A	a	DT
cord-344093-3bniy5b5	412	21	virus	virus	NN
cord-344093-3bniy5b5	412	22	-	-	HYPH
cord-344093-3bniy5b5	412	23	induced	induce	VBN
cord-344093-3bniy5b5	412	24	expression	expression	NN
cord-344093-3bniy5b5	412	25	of	of	IN
cord-344093-3bniy5b5	412	26	ISG20	ISG20	NNP
cord-344093-3bniy5b5	412	27	inhibits	inhibit	VBZ
cord-344093-3bniy5b5	412	28	viral	viral	JJ
cord-344093-3bniy5b5	412	29	replication	replication	NN
cord-344093-3bniy5b5	412	30	by	by	IN
cord-344093-3bniy5b5	412	31	interacting	interact	VBG
cord-344093-3bniy5b5	412	32	with	with	IN
cord-344093-3bniy5b5	412	33	nucleoprotein	nucleoprotein	NNP
cord-344093-3bniy5b5	412	34	Intranasal	Intranasal	NNP
cord-344093-3bniy5b5	412	35	administration	administration	NN
cord-344093-3bniy5b5	412	36	of	of	IN
cord-344093-3bniy5b5	412	37	alpha	alpha	NNP
cord-344093-3bniy5b5	412	38	interferon	interferon	NNP
cord-344093-3bniy5b5	412	39	reduces	reduce	VBZ
cord-344093-3bniy5b5	412	40	seasonal	seasonal	JJ
cord-344093-3bniy5b5	412	41	influenza	influenza	NN
cord-344093-3bniy5b5	412	42	A	a	DT
cord-344093-3bniy5b5	412	43	virus	virus	NN
cord-344093-3bniy5b5	412	44	morbidity	morbidity	NN
cord-344093-3bniy5b5	412	45	in	in	IN
cord-344093-3bniy5b5	412	46	ferrets	ferret	NNS
cord-344093-3bniy5b5	412	47	Transmission	Transmission	NNP
cord-344093-3bniy5b5	412	48	of	of	IN
cord-344093-3bniy5b5	412	49	pandemic	pandemic	NN
cord-344093-3bniy5b5	412	50	H1N1	H1N1	NNP
cord-344093-3bniy5b5	412	51	influenza	influenza	NN
cord-344093-3bniy5b5	412	52	virus	virus	NN
cord-344093-3bniy5b5	412	53	and	and	CC
cord-344093-3bniy5b5	412	54	impact	impact	NN
cord-344093-3bniy5b5	412	55	of	of	IN
cord-344093-3bniy5b5	412	56	prior	prior	JJ
cord-344093-3bniy5b5	412	57	exposure	exposure	NN
cord-344093-3bniy5b5	412	58	to	to	IN
cord-344093-3bniy5b5	412	59	seasonal	seasonal	JJ
cord-344093-3bniy5b5	412	60	strains	strain	NNS
cord-344093-3bniy5b5	412	61	or	or	CC
cord-344093-3bniy5b5	412	62	interferon	interferon	NN
cord-344093-3bniy5b5	412	63	treatment	treatment	NN
cord-344093-3bniy5b5	412	64	Passive	Passive	NNP
cord-344093-3bniy5b5	412	65	interferon	interferon	NNP
cord-344093-3bniy5b5	412	66	protection	protection	NN
cord-344093-3bniy5b5	412	67	in	in	IN
cord-344093-3bniy5b5	412	68	mouse	mouse	NN
cord-344093-3bniy5b5	412	69	influenza	influenza	NN
cord-344093-3bniy5b5	413	1	The	the	DT
cord-344093-3bniy5b5	413	2	Mx1	mx1	JJ
cord-344093-3bniy5b5	413	3	gene	gene	NN
cord-344093-3bniy5b5	413	4	protects	protect	VBZ
cord-344093-3bniy5b5	413	5	mice	mouse	NNS
cord-344093-3bniy5b5	413	6	against	against	IN
cord-344093-3bniy5b5	413	7	the	the	DT
cord-344093-3bniy5b5	413	8	pandemic	pandemic	NN
cord-344093-3bniy5b5	413	9	1918	1918	CD
cord-344093-3bniy5b5	413	10	and	and	CC
cord-344093-3bniy5b5	413	11	highly	highly	RB
cord-344093-3bniy5b5	413	12	lethal	lethal	JJ
cord-344093-3bniy5b5	413	13	human	human	NN
cord-344093-3bniy5b5	413	14	H5N1	H5N1	NNP
cord-344093-3bniy5b5	413	15	influenza	influenza	NN
cord-344093-3bniy5b5	413	16	viruses	viruse	VBZ
cord-344093-3bniy5b5	413	17	Activity	activity	NN
cord-344093-3bniy5b5	413	18	and	and	CC
cord-344093-3bniy5b5	413	19	regulation	regulation	NN
cord-344093-3bniy5b5	413	20	of	of	IN
cord-344093-3bniy5b5	413	21	alpha	alpha	NN
cord-344093-3bniy5b5	413	22	interferon	interferon	NN
cord-344093-3bniy5b5	413	23	in	in	IN
cord-344093-3bniy5b5	413	24	respiratory	respiratory	JJ
cord-344093-3bniy5b5	413	25	syncytial	syncytial	JJ
cord-344093-3bniy5b5	413	26	virus	virus	NN
cord-344093-3bniy5b5	413	27	and	and	CC
cord-344093-3bniy5b5	414	1	human	human	NNP
cord-344093-3bniy5b5	414	2	metapneumovirus	metapneumovirus	NNP
cord-344093-3bniy5b5	414	3	experimental	experimental	JJ
cord-344093-3bniy5b5	414	4	infections	infection	NNS
cord-344093-3bniy5b5	414	5	Pegylated	Pegylated	NNP
cord-344093-3bniy5b5	414	6	interferon	interferon	NN
cord-344093-3bniy5b5	414	7	-	-	HYPH
cord-344093-3bniy5b5	414	8	α	α	NN
cord-344093-3bniy5b5	414	9	protects	protect	VBZ
cord-344093-3bniy5b5	414	10	type	type	NN
cord-344093-3bniy5b5	414	11	1	1	CD
cord-344093-3bniy5b5	414	12	pneumocytes	pneumocyte	NNS
cord-344093-3bniy5b5	414	13	against	against	IN
cord-344093-3bniy5b5	414	14	SARS	SARS	NNP
cord-344093-3bniy5b5	414	15	coronavirus	coronavirus	NN
cord-344093-3bniy5b5	414	16	infection	infection	NN
cord-344093-3bniy5b5	414	17	in	in	IN
cord-344093-3bniy5b5	414	18	macaques	macaque	NNS
cord-344093-3bniy5b5	414	19	Treatment	Treatment	NNP
cord-344093-3bniy5b5	414	20	with	with	IN
cord-344093-3bniy5b5	414	21	interferon	interferon	NN
cord-344093-3bniy5b5	414	22	-	-	HYPH
cord-344093-3bniy5b5	414	23	α2b	α2b	JJ
cord-344093-3bniy5b5	414	24	and	and	CC
cord-344093-3bniy5b5	414	25	ribavirin	ribavirin	NN
cord-344093-3bniy5b5	414	26	improves	improve	VBZ
cord-344093-3bniy5b5	414	27	outcome	outcome	NN
cord-344093-3bniy5b5	414	28	in	in	IN
cord-344093-3bniy5b5	414	29	MERS	MERS	NNP
cord-344093-3bniy5b5	414	30	-	-	HYPH
cord-344093-3bniy5b5	414	31	CoV	CoV	NNP
cord-344093-3bniy5b5	414	32	-	-	HYPH
cord-344093-3bniy5b5	414	33	infected	infect	VBN
cord-344093-3bniy5b5	414	34	rhesus	rhesu	NNS
cord-344093-3bniy5b5	414	35	macaques	macaque	NNS
cord-344093-3bniy5b5	414	36	Identification	identification	NN
cord-344093-3bniy5b5	414	37	of	of	IN
cord-344093-3bniy5b5	414	38	a	a	DT
cord-344093-3bniy5b5	414	39	role	role	NN
cord-344093-3bniy5b5	414	40	for	for	IN
cord-344093-3bniy5b5	414	41	TRIM29	trim29	NN
cord-344093-3bniy5b5	414	42	in	in	IN
cord-344093-3bniy5b5	414	43	the	the	DT
cord-344093-3bniy5b5	414	44	control	control	NN
cord-344093-3bniy5b5	414	45	of	of	IN
cord-344093-3bniy5b5	414	46	innate	innate	JJ
cord-344093-3bniy5b5	414	47	immunity	immunity	NN
cord-344093-3bniy5b5	414	48	in	in	IN
cord-344093-3bniy5b5	414	49	the	the	DT
cord-344093-3bniy5b5	414	50	respiratory	respiratory	JJ
cord-344093-3bniy5b5	414	51	tract	tract	NN
cord-344093-3bniy5b5	414	52	Functional	functional	JJ
cord-344093-3bniy5b5	414	53	role	role	NN
cord-344093-3bniy5b5	414	54	of	of	IN
cord-344093-3bniy5b5	414	55	type	type	NN
cord-344093-3bniy5b5	414	56	I	-PRON-	PRP
cord-344093-3bniy5b5	414	57	and	and	CC
cord-344093-3bniy5b5	414	58	type	type	NN
cord-344093-3bniy5b5	414	59	II	II	NNP
cord-344093-3bniy5b5	414	60	interferons	interferon	NNS
cord-344093-3bniy5b5	414	61	in	in	IN
cord-344093-3bniy5b5	414	62	antiviral	antiviral	JJ
cord-344093-3bniy5b5	414	63	defense	defense	NN
cord-344093-3bniy5b5	415	1	Alpha	alpha	NN
cord-344093-3bniy5b5	415	2	/	/	,
cord-344093-3bniy5b5	415	3	Beta	beta	NN
cord-344093-3bniy5b5	416	1	interferon	interferon	NN
cord-344093-3bniy5b5	416	2	receptor	receptor	NN
cord-344093-3bniy5b5	416	3	signaling	signaling	NN
cord-344093-3bniy5b5	416	4	amplifies	amplify	VBZ
cord-344093-3bniy5b5	416	5	early	early	JJ
cord-344093-3bniy5b5	416	6	proinflammatory	proinflammatory	JJ
cord-344093-3bniy5b5	416	7	cytokine	cytokine	NN
cord-344093-3bniy5b5	416	8	production	production	NN
cord-344093-3bniy5b5	416	9	in	in	IN
cord-344093-3bniy5b5	416	10	the	the	DT
cord-344093-3bniy5b5	416	11	lung	lung	NN
cord-344093-3bniy5b5	416	12	during	during	IN
cord-344093-3bniy5b5	416	13	respiratory	respiratory	JJ
cord-344093-3bniy5b5	416	14	syncytial	syncytial	JJ
cord-344093-3bniy5b5	416	15	virus	virus	NN
cord-344093-3bniy5b5	416	16	infection	infection	NN
cord-344093-3bniy5b5	416	17	Disease	Disease	NNP
cord-344093-3bniy5b5	416	18	-	-	HYPH
cord-344093-3bniy5b5	416	19	promoting	promote	VBG
cord-344093-3bniy5b5	416	20	effects	effect	NNS
cord-344093-3bniy5b5	416	21	of	of	IN
cord-344093-3bniy5b5	416	22	type	type	NN
cord-344093-3bniy5b5	416	23	I	-PRON-	PRP
cord-344093-3bniy5b5	416	24	interferons	interferon	NNS
cord-344093-3bniy5b5	416	25	in	in	IN
cord-344093-3bniy5b5	416	26	viral	viral	JJ
cord-344093-3bniy5b5	416	27	,	,	,
cord-344093-3bniy5b5	416	28	bacterial	bacterial	JJ
cord-344093-3bniy5b5	416	29	,	,	,
cord-344093-3bniy5b5	416	30	and	and	CC
cord-344093-3bniy5b5	416	31	coinfections	coinfection	NNS
cord-344093-3bniy5b5	417	1	Interferon	interferon	NN
cord-344093-3bniy5b5	417	2	-	-	HYPH
cord-344093-3bniy5b5	417	3	λ	λ	NNP
cord-344093-3bniy5b5	417	4	contributes	contribute	VBZ
cord-344093-3bniy5b5	417	5	to	to	TO
cord-344093-3bniy5b5	417	6	innate	innate	JJ
cord-344093-3bniy5b5	417	7	immunity	immunity	NN
cord-344093-3bniy5b5	417	8	of	of	IN
cord-344093-3bniy5b5	417	9	mice	mouse	NNS
cord-344093-3bniy5b5	417	10	against	against	IN
cord-344093-3bniy5b5	417	11	influenza	influenza	NN
cord-344093-3bniy5b5	417	12	A	a	DT
cord-344093-3bniy5b5	417	13	virus	virus	NN
cord-344093-3bniy5b5	417	14	but	but	CC
cord-344093-3bniy5b5	417	15	not	not	RB
cord-344093-3bniy5b5	417	16	against	against	IN
cord-344093-3bniy5b5	417	17	hepatotropic	hepatotropic	NNP
cord-344093-3bniy5b5	417	18	viruses	virus	NNS
cord-344093-3bniy5b5	417	19	Lambda	Lambda	NNP
cord-344093-3bniy5b5	417	20	interferon	interferon	NN
cord-344093-3bniy5b5	418	1	renders	render	NNS
cord-344093-3bniy5b5	419	1	epithelial	epithelial	JJ
cord-344093-3bniy5b5	419	2	cells	cell	NNS
cord-344093-3bniy5b5	419	3	of	of	IN
cord-344093-3bniy5b5	419	4	the	the	DT
cord-344093-3bniy5b5	419	5	respiratory	respiratory	JJ
cord-344093-3bniy5b5	419	6	and	and	CC
cord-344093-3bniy5b5	419	7	gastrointestinal	gastrointestinal	JJ
cord-344093-3bniy5b5	419	8	tracts	tract	NNS
cord-344093-3bniy5b5	419	9	resistant	resistant	JJ
cord-344093-3bniy5b5	419	10	to	to	IN
cord-344093-3bniy5b5	419	11	viral	viral	JJ
cord-344093-3bniy5b5	419	12	infections	infection	NNS
cord-344093-3bniy5b5	419	13	Type	type	NN
cord-344093-3bniy5b5	419	14	I	i	NN
cord-344093-3bniy5b5	419	15	and	and	CC
cord-344093-3bniy5b5	419	16	type	type	NN
cord-344093-3bniy5b5	419	17	III	iii	CD
cord-344093-3bniy5b5	419	18	interferons	interferon	NNS
cord-344093-3bniy5b5	419	19	drive	drive	VBP
cord-344093-3bniy5b5	419	20	redundant	redundant	JJ
cord-344093-3bniy5b5	419	21	amplification	amplification	NN
cord-344093-3bniy5b5	419	22	loops	loop	NNS
cord-344093-3bniy5b5	419	23	to	to	TO
cord-344093-3bniy5b5	419	24	induce	induce	VB
cord-344093-3bniy5b5	419	25	a	a	DT
cord-344093-3bniy5b5	419	26	transcriptional	transcriptional	JJ
cord-344093-3bniy5b5	419	27	signature	signature	NN
cord-344093-3bniy5b5	419	28	in	in	IN
cord-344093-3bniy5b5	419	29	influenza	influenza	NN
cord-344093-3bniy5b5	419	30	-	-	HYPH
cord-344093-3bniy5b5	419	31	infected	infect	VBN
cord-344093-3bniy5b5	419	32	airway	airway	NN
cord-344093-3bniy5b5	419	33	epithelia	epithelium	NNS
cord-344093-3bniy5b5	419	34	IFITM3	IFITM3	NNP
cord-344093-3bniy5b5	419	35	restricts	restrict	VBZ
cord-344093-3bniy5b5	419	36	the	the	DT
cord-344093-3bniy5b5	419	37	morbidity	morbidity	NN
cord-344093-3bniy5b5	419	38	and	and	CC
cord-344093-3bniy5b5	419	39	mortality	mortality	NN
cord-344093-3bniy5b5	419	40	associated	associate	VBN
cord-344093-3bniy5b5	419	41	with	with	IN
cord-344093-3bniy5b5	419	42	influenza	influenza	NN
cord-344093-3bniy5b5	419	43	Sendai	Sendai	NNP
cord-344093-3bniy5b5	419	44	virus	virus	NN
cord-344093-3bniy5b5	419	45	infection	infection	NN
cord-344093-3bniy5b5	419	46	induces	induce	VBZ
cord-344093-3bniy5b5	419	47	efficient	efficient	JJ
cord-344093-3bniy5b5	419	48	adaptive	adaptive	JJ
cord-344093-3bniy5b5	419	49	immunity	immunity	NN
cord-344093-3bniy5b5	419	50	independently	independently	RB
cord-344093-3bniy5b5	419	51	of	of	IN
cord-344093-3bniy5b5	419	52	type	type	NN
cord-344093-3bniy5b5	420	1	I	-PRON-	PRP
cord-344093-3bniy5b5	420	2	interferons	interferons	VBP
cord-344093-3bniy5b5	420	3	Pathogenic	pathogenic	JJ
cord-344093-3bniy5b5	420	4	potential	potential	NN
cord-344093-3bniy5b5	420	5	of	of	IN
cord-344093-3bniy5b5	420	6	interferon	interferon	NN
cord-344093-3bniy5b5	420	7	Aβ	Aβ	NNP
cord-344093-3bniy5b5	420	8	in	in	IN
cord-344093-3bniy5b5	420	9	acute	acute	JJ
cord-344093-3bniy5b5	420	10	influenza	influenza	NN
cord-344093-3bniy5b5	420	11	infection	infection	NN
cord-344093-3bniy5b5	421	1	Sendai	Sendai	NNP
cord-344093-3bniy5b5	421	2	virus	virus	NN
cord-344093-3bniy5b5	421	3	pathogenesis	pathogenesis	NN
cord-344093-3bniy5b5	421	4	in	in	IN
cord-344093-3bniy5b5	421	5	mice	mouse	NNS
cord-344093-3bniy5b5	421	6	is	be	VBZ
cord-344093-3bniy5b5	421	7	prevented	prevent	VBN
cord-344093-3bniy5b5	421	8	by	by	IN
cord-344093-3bniy5b5	421	9	Ifit2	ifit2	CD
cord-344093-3bniy5b5	421	10	and	and	CC
cord-344093-3bniy5b5	421	11	exacerbated	exacerbate	VBN
cord-344093-3bniy5b5	421	12	by	by	IN
cord-344093-3bniy5b5	421	13	interferon	interferon	NN
cord-344093-3bniy5b5	421	14	Dysregulated	Dysregulated	NNP
cord-344093-3bniy5b5	421	15	type	type	NN
cord-344093-3bniy5b5	422	1	I	-PRON-	PRP
cord-344093-3bniy5b5	422	2	interferon	interferon	VBD
cord-344093-3bniy5b5	422	3	and	and	CC
cord-344093-3bniy5b5	422	4	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	422	5	monocyte	monocyte	JJ
cord-344093-3bniy5b5	422	6	-	-	HYPH
cord-344093-3bniy5b5	422	7	macrophage	macrophage	NN
cord-344093-3bniy5b5	422	8	responses	response	NNS
cord-344093-3bniy5b5	422	9	cause	cause	VBP
cord-344093-3bniy5b5	422	10	lethal	lethal	JJ
cord-344093-3bniy5b5	422	11	pneumonia	pneumonia	NN
cord-344093-3bniy5b5	422	12	in	in	IN
cord-344093-3bniy5b5	422	13	SARS	SARS	NNP
cord-344093-3bniy5b5	422	14	-	-	HYPH
cord-344093-3bniy5b5	422	15	CoV	CoV	NNP
cord-344093-3bniy5b5	422	16	-	-	HYPH
cord-344093-3bniy5b5	422	17	infected	infect	VBN
cord-344093-3bniy5b5	422	18	mice	mouse	NNS
cord-344093-3bniy5b5	422	19	Protection	Protection	NNP
cord-344093-3bniy5b5	422	20	from	from	IN
cord-344093-3bniy5b5	422	21	lethal	lethal	JJ
cord-344093-3bniy5b5	422	22	influenza	influenza	NN
cord-344093-3bniy5b5	422	23	virus	virus	NN
cord-344093-3bniy5b5	422	24	challenge	challenge	NN
cord-344093-3bniy5b5	422	25	by	by	IN
cord-344093-3bniy5b5	422	26	oral	oral	JJ
cord-344093-3bniy5b5	422	27	type	type	NN
cord-344093-3bniy5b5	422	28	1	1	CD
cord-344093-3bniy5b5	423	1	interferon	interferon	NNP
cord-344093-3bniy5b5	423	2	Extremes	Extremes	NNPS
cord-344093-3bniy5b5	423	3	of	of	IN
cord-344093-3bniy5b5	423	4	interferon	interferon	NN
cord-344093-3bniy5b5	423	5	-	-	HYPH
cord-344093-3bniy5b5	423	6	stimulated	stimulate	VBN
cord-344093-3bniy5b5	423	7	gene	gene	NN
cord-344093-3bniy5b5	423	8	expression	expression	NN
cord-344093-3bniy5b5	423	9	associate	associate	JJ
cord-344093-3bniy5b5	423	10	with	with	IN
cord-344093-3bniy5b5	423	11	worse	bad	JJR
cord-344093-3bniy5b5	423	12	outcomes	outcome	NNS
cord-344093-3bniy5b5	423	13	in	in	IN
cord-344093-3bniy5b5	423	14	the	the	DT
cord-344093-3bniy5b5	423	15	acute	acute	JJ
cord-344093-3bniy5b5	423	16	respiratory	respiratory	JJ
cord-344093-3bniy5b5	423	17	distress	distress	NN
cord-344093-3bniy5b5	423	18	syndrome	syndrome	NN
cord-344093-3bniy5b5	424	1	Novel	novel	JJ
cord-344093-3bniy5b5	424	2	growth	growth	NN
cord-344093-3bniy5b5	424	3	and	and	CC
cord-344093-3bniy5b5	424	4	death	death	NN
cord-344093-3bniy5b5	424	5	related	relate	VBN
cord-344093-3bniy5b5	424	6	interferon	interferon	NN
cord-344093-3bniy5b5	424	7	-	-	HYPH
cord-344093-3bniy5b5	424	8	stimulated	stimulate	VBN
cord-344093-3bniy5b5	424	9	genes	gene	NNS
cord-344093-3bniy5b5	424	10	(	(	-LRB-
cord-344093-3bniy5b5	424	11	ISGs	ISGs	NNP
cord-344093-3bniy5b5	424	12	)	)	-RRB-
cord-344093-3bniy5b5	424	13	in	in	IN
cord-344093-3bniy5b5	424	14	melanoma	melanoma	NN
cord-344093-3bniy5b5	424	15	:	:	:
cord-344093-3bniy5b5	424	16	greater	great	JJR
cord-344093-3bniy5b5	424	17	potency	potency	NN
cord-344093-3bniy5b5	424	18	of	of	IN
cord-344093-3bniy5b5	424	19	IFN	IFN	NNP
cord-344093-3bniy5b5	424	20	-	-	HYPH
cord-344093-3bniy5b5	424	21	beta	beta	NN
cord-344093-3bniy5b5	424	22	compared	compare	VBN
cord-344093-3bniy5b5	424	23	with	with	IN
cord-344093-3bniy5b5	424	24	IFN	IFN	NNP
cord-344093-3bniy5b5	424	25	-	-	HYPH
cord-344093-3bniy5b5	424	26	alpha2	alpha2	NNP
cord-344093-3bniy5b5	424	27	Interferon	interferon	NN
cord-344093-3bniy5b5	424	28	-	-	HYPH
cord-344093-3bniy5b5	424	29	alpha	alpha	NN
cord-344093-3bniy5b5	424	30	and	and	CC
cord-344093-3bniy5b5	424	31	-beta	-beta	NN
cord-344093-3bniy5b5	425	1	differentially	differentially	RB
cord-344093-3bniy5b5	425	2	regulate	regulate	VB
cord-344093-3bniy5b5	425	3	osteoclastogenesis	osteoclastogenesis	NN
cord-344093-3bniy5b5	425	4	:	:	:
cord-344093-3bniy5b5	425	5	role	role	NN
cord-344093-3bniy5b5	425	6	of	of	IN
cord-344093-3bniy5b5	425	7	differential	differential	JJ
cord-344093-3bniy5b5	425	8	induction	induction	NN
cord-344093-3bniy5b5	425	9	of	of	IN
cord-344093-3bniy5b5	425	10	chemokine	chemokine	NN
cord-344093-3bniy5b5	425	11	CXCL11	CXCL11	NNP
cord-344093-3bniy5b5	425	12	expression	expression	NN
cord-344093-3bniy5b5	425	13	INTERFEROME	INTERFEROME	NNP
cord-344093-3bniy5b5	425	14	:	:	:
cord-344093-3bniy5b5	425	15	the	the	DT
cord-344093-3bniy5b5	425	16	database	database	NN
cord-344093-3bniy5b5	425	17	of	of	IN
cord-344093-3bniy5b5	425	18	interferon	interferon	NN
cord-344093-3bniy5b5	425	19	regulated	regulate	VBN
cord-344093-3bniy5b5	425	20	genes	gene	NNS
cord-344093-3bniy5b5	426	1	Stochastic	stochastic	JJ
cord-344093-3bniy5b5	426	2	receptor	receptor	NN
cord-344093-3bniy5b5	426	3	expression	expression	NN
cord-344093-3bniy5b5	426	4	determines	determine	VBZ
cord-344093-3bniy5b5	426	5	cell	cell	NN
cord-344093-3bniy5b5	426	6	fate	fate	NN
cord-344093-3bniy5b5	426	7	upon	upon	IN
cord-344093-3bniy5b5	426	8	interferon	interferon	NN
cord-344093-3bniy5b5	426	9	treatment	treatment	NN
cord-344093-3bniy5b5	426	10	Identification	Identification	NNP
cord-344093-3bniy5b5	426	11	of	of	IN
cord-344093-3bniy5b5	426	12	a	a	DT
cord-344093-3bniy5b5	426	13	nuclear	nuclear	JJ
cord-344093-3bniy5b5	426	14	Stat1	Stat1	NNS
cord-344093-3bniy5b5	426	15	protein	protein	NN
cord-344093-3bniy5b5	426	16	tyrosine	tyrosine	NN
cord-344093-3bniy5b5	426	17	phosphatase	phosphatase	NN
cord-344093-3bniy5b5	426	18	Differential	differential	JJ
cord-344093-3bniy5b5	426	19	regulation	regulation	NN
cord-344093-3bniy5b5	426	20	of	of	IN
cord-344093-3bniy5b5	426	21	the	the	DT
cord-344093-3bniy5b5	426	22	alpha	alpha	NN
cord-344093-3bniy5b5	426	23	/	/	SYM
cord-344093-3bniy5b5	426	24	beta	beta	NN
cord-344093-3bniy5b5	426	25	interferon	interferon	NN
cord-344093-3bniy5b5	426	26	-	-	HYPH
cord-344093-3bniy5b5	426	27	stimulated	stimulate	VBN
cord-344093-3bniy5b5	426	28	Jak	Jak	NNP
cord-344093-3bniy5b5	426	29	/	/	SYM
cord-344093-3bniy5b5	426	30	Stat	Stat	NNP
cord-344093-3bniy5b5	426	31	pathway	pathway	NN
cord-344093-3bniy5b5	426	32	by	by	IN
cord-344093-3bniy5b5	426	33	the	the	DT
cord-344093-3bniy5b5	426	34	SH2	SH2	NNP
cord-344093-3bniy5b5	426	35	domain	domain	NN
cord-344093-3bniy5b5	426	36	-	-	HYPH
cord-344093-3bniy5b5	426	37	containing	contain	VBG
cord-344093-3bniy5b5	426	38	tyrosine	tyrosine	NN
cord-344093-3bniy5b5	426	39	phosphatase	phosphatase	NN
cord-344093-3bniy5b5	426	40	SHPTP1	SHPTP1	NNP
cord-344093-3bniy5b5	426	41	SOCS	SOCS	NNP
cord-344093-3bniy5b5	426	42	proteins	protein	NNS
cord-344093-3bniy5b5	426	43	,	,	,
cord-344093-3bniy5b5	426	44	cytokine	cytokine	NN
cord-344093-3bniy5b5	426	45	signalling	signalling	NN
cord-344093-3bniy5b5	426	46	and	and	CC
cord-344093-3bniy5b5	426	47	immune	immune	JJ
cord-344093-3bniy5b5	426	48	regulation	regulation	NN
cord-344093-3bniy5b5	427	1	Site	site	NN
cord-344093-3bniy5b5	427	2	-	-	HYPH
cord-344093-3bniy5b5	427	3	specific	specific	JJ
cord-344093-3bniy5b5	427	4	ubiquitination	ubiquitination	NN
cord-344093-3bniy5b5	427	5	exposes	expose	VBZ
cord-344093-3bniy5b5	427	6	a	a	DT
cord-344093-3bniy5b5	427	7	linear	linear	JJ
cord-344093-3bniy5b5	427	8	motif	motif	NN
cord-344093-3bniy5b5	427	9	to	to	TO
cord-344093-3bniy5b5	427	10	promote	promote	VB
cord-344093-3bniy5b5	427	11	interferon	interferon	NN
cord-344093-3bniy5b5	427	12	-	-	HYPH
cord-344093-3bniy5b5	427	13	alpha	alpha	NN
cord-344093-3bniy5b5	427	14	receptor	receptor	NN
cord-344093-3bniy5b5	427	15	endocytosis	endocytosis	NN
cord-344093-3bniy5b5	428	1	Triggering	trigger	VBG
cord-344093-3bniy5b5	428	2	ubiquitination	ubiquitination	NN
cord-344093-3bniy5b5	428	3	of	of	IN
cord-344093-3bniy5b5	428	4	IFNAR1	ifnar1	NN
cord-344093-3bniy5b5	428	5	protects	protect	VBZ
cord-344093-3bniy5b5	428	6	tissues	tissue	NNS
cord-344093-3bniy5b5	428	7	from	from	IN
cord-344093-3bniy5b5	428	8	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	428	9	injury	injury	NN
cord-344093-3bniy5b5	428	10	Type	type	NN
cord-344093-3bniy5b5	428	11	I	-PRON-	PRP
cord-344093-3bniy5b5	428	12	interferon	interferon	NN
cord-344093-3bniy5b5	428	13	restricts	restrict	VBZ
cord-344093-3bniy5b5	428	14	type	type	NN
cord-344093-3bniy5b5	428	15	2	2	CD
cord-344093-3bniy5b5	428	16	immunopathology	immunopathology	NN
cord-344093-3bniy5b5	428	17	through	through	IN
cord-344093-3bniy5b5	428	18	the	the	DT
cord-344093-3bniy5b5	428	19	regulation	regulation	NN
cord-344093-3bniy5b5	428	20	of	of	IN
cord-344093-3bniy5b5	428	21	group	group	NN
cord-344093-3bniy5b5	428	22	2	2	CD
cord-344093-3bniy5b5	428	23	innate	innate	JJ
cord-344093-3bniy5b5	428	24	lymphoid	lymphoid	JJ
cord-344093-3bniy5b5	428	25	cells	cell	NNS
cord-344093-3bniy5b5	428	26	Differential	differential	JJ
cord-344093-3bniy5b5	428	27	regulation	regulation	NN
cord-344093-3bniy5b5	428	28	of	of	IN
cord-344093-3bniy5b5	428	29	human	human	JJ
cord-344093-3bniy5b5	428	30	blood	blood	NN
cord-344093-3bniy5b5	428	31	dendritic	dendritic	JJ
cord-344093-3bniy5b5	428	32	cell	cell	NN
cord-344093-3bniy5b5	428	33	subsets	subset	NNS
cord-344093-3bniy5b5	428	34	by	by	IN
cord-344093-3bniy5b5	428	35	IFNs	IFNs	NNP
cord-344093-3bniy5b5	428	36	Type	type	NN
cord-344093-3bniy5b5	428	37	I	-PRON-	PRP
cord-344093-3bniy5b5	428	38	interferons	interferon	NNS
cord-344093-3bniy5b5	428	39	produced	produce	VBN
cord-344093-3bniy5b5	428	40	by	by	IN
cord-344093-3bniy5b5	428	41	dendritic	dendritic	JJ
cord-344093-3bniy5b5	428	42	cells	cell	NNS
cord-344093-3bniy5b5	428	43	promote	promote	VBP
cord-344093-3bniy5b5	428	44	their	-PRON-	PRP$
cord-344093-3bniy5b5	428	45	phenotypic	phenotypic	JJ
cord-344093-3bniy5b5	428	46	and	and	CC
cord-344093-3bniy5b5	428	47	functional	functional	JJ
cord-344093-3bniy5b5	428	48	activation	activation	NN
cord-344093-3bniy5b5	428	49	Virus	virus	NN
cord-344093-3bniy5b5	428	50	-	-	HYPH
cord-344093-3bniy5b5	428	51	induced	induce	VBN
cord-344093-3bniy5b5	428	52	transient	transient	JJ
cord-344093-3bniy5b5	428	53	immune	immune	JJ
cord-344093-3bniy5b5	428	54	suppression	suppression	NN
cord-344093-3bniy5b5	428	55	and	and	CC
cord-344093-3bniy5b5	428	56	the	the	DT
cord-344093-3bniy5b5	428	57	inhibition	inhibition	NN
cord-344093-3bniy5b5	428	58	of	of	IN
cord-344093-3bniy5b5	428	59	T	T	NNP
cord-344093-3bniy5b5	428	60	cell	cell	NN
cord-344093-3bniy5b5	428	61	proliferation	proliferation	NN
cord-344093-3bniy5b5	428	62	by	by	IN
cord-344093-3bniy5b5	428	63	type	type	NN
cord-344093-3bniy5b5	429	1	I	-PRON-	PRP
cord-344093-3bniy5b5	430	1	interferon	interferon	NNP
cord-344093-3bniy5b5	431	1	A	a	DT
cord-344093-3bniy5b5	431	2	temporal	temporal	JJ
cord-344093-3bniy5b5	431	3	role	role	NN
cord-344093-3bniy5b5	431	4	of	of	IN
cord-344093-3bniy5b5	431	5	type	type	NN
cord-344093-3bniy5b5	432	1	I	-PRON-	PRP
cord-344093-3bniy5b5	432	2	interferon	interferon	RB
cord-344093-3bniy5b5	432	3	signaling	signal	VBG
cord-344093-3bniy5b5	432	4	in	in	IN
cord-344093-3bniy5b5	432	5	CD8	CD8	NNP
cord-344093-3bniy5b5	432	6	+	+	CC
cord-344093-3bniy5b5	432	7	T	T	NNP
cord-344093-3bniy5b5	432	8	cell	cell	NN
cord-344093-3bniy5b5	432	9	maturation	maturation	NN
cord-344093-3bniy5b5	432	10	during	during	IN
cord-344093-3bniy5b5	432	11	acute	acute	JJ
cord-344093-3bniy5b5	432	12	West	West	NNP
cord-344093-3bniy5b5	432	13	Nile	Nile	NNP
cord-344093-3bniy5b5	432	14	virus	virus	NN
cord-344093-3bniy5b5	432	15	infection	infection	NN
cord-344093-3bniy5b5	433	1	The	the	DT
cord-344093-3bniy5b5	433	2	role	role	NN
cord-344093-3bniy5b5	433	3	of	of	IN
cord-344093-3bniy5b5	433	4	alpha/	alpha/	CD
cord-344093-3bniy5b5	433	5	beta	beta	NN
cord-344093-3bniy5b5	433	6	and	and	CC
cord-344093-3bniy5b5	433	7	gamma	gamma	NN
cord-344093-3bniy5b5	433	8	interferons	interferon	NNS
cord-344093-3bniy5b5	433	9	in	in	IN
cord-344093-3bniy5b5	433	10	development	development	NN
cord-344093-3bniy5b5	433	11	of	of	IN
cord-344093-3bniy5b5	433	12	immunity	immunity	NN
cord-344093-3bniy5b5	433	13	to	to	TO
cord-344093-3bniy5b5	433	14	influenza	influenza	NN
cord-344093-3bniy5b5	433	15	A	a	DT
cord-344093-3bniy5b5	433	16	virus	virus	NN
cord-344093-3bniy5b5	433	17	in	in	IN
cord-344093-3bniy5b5	433	18	mice	mouse	NNS
cord-344093-3bniy5b5	433	19	Cutting	cutting	NN
cord-344093-3bniy5b5	433	20	edge	edge	NN
cord-344093-3bniy5b5	433	21	:	:	:
cord-344093-3bniy5b5	433	22	enhancement	enhancement	NN
cord-344093-3bniy5b5	433	23	of	of	IN
cord-344093-3bniy5b5	433	24	antibody	antibody	NN
cord-344093-3bniy5b5	433	25	responses	response	NNS
cord-344093-3bniy5b5	433	26	through	through	IN
cord-344093-3bniy5b5	433	27	direct	direct	JJ
cord-344093-3bniy5b5	433	28	stimulation	stimulation	NN
cord-344093-3bniy5b5	433	29	of	of	IN
cord-344093-3bniy5b5	433	30	B	b	NN
cord-344093-3bniy5b5	433	31	and	and	CC
cord-344093-3bniy5b5	433	32	T	t	NN
cord-344093-3bniy5b5	433	33	cells	cell	NNS
cord-344093-3bniy5b5	433	34	by	by	IN
cord-344093-3bniy5b5	433	35	type	type	NN
cord-344093-3bniy5b5	434	1	I	-PRON-	PRP
cord-344093-3bniy5b5	434	2	IFN	IFN	NNP
cord-344093-3bniy5b5	434	3	Modulating	modulate	VBG
cord-344093-3bniy5b5	434	4	the	the	DT
cord-344093-3bniy5b5	434	5	innate	innate	JJ
cord-344093-3bniy5b5	434	6	immune	immune	JJ
cord-344093-3bniy5b5	434	7	response	response	NN
cord-344093-3bniy5b5	434	8	to	to	TO
cord-344093-3bniy5b5	434	9	influenza	influenza	VB
cord-344093-3bniy5b5	434	10	A	a	DT
cord-344093-3bniy5b5	434	11	virus	virus	NN
cord-344093-3bniy5b5	434	12	:	:	:
cord-344093-3bniy5b5	434	13	potential	potential	JJ
cord-344093-3bniy5b5	434	14	therapeutic	therapeutic	JJ
cord-344093-3bniy5b5	434	15	use	use	NN
cord-344093-3bniy5b5	434	16	of	of	IN
cord-344093-3bniy5b5	434	17	anti	anti	JJ
cord-344093-3bniy5b5	434	18	-	-	JJ
cord-344093-3bniy5b5	434	19	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	434	20	drugs	drug	NNS
cord-344093-3bniy5b5	434	21	Early	early	RB
cord-344093-3bniy5b5	434	22	and	and	CC
cord-344093-3bniy5b5	434	23	sustained	sustain	VBD
cord-344093-3bniy5b5	434	24	innate	innate	JJ
cord-344093-3bniy5b5	434	25	immune	immune	JJ
cord-344093-3bniy5b5	434	26	response	response	NN
cord-344093-3bniy5b5	434	27	defines	define	VBZ
cord-344093-3bniy5b5	434	28	pathology	pathology	NN
cord-344093-3bniy5b5	434	29	and	and	CC
cord-344093-3bniy5b5	434	30	death	death	NN
cord-344093-3bniy5b5	434	31	in	in	IN
cord-344093-3bniy5b5	434	32	nonhuman	nonhuman	NN
cord-344093-3bniy5b5	434	33	primates	primate	NNS
cord-344093-3bniy5b5	434	34	infected	infect	VBN
cord-344093-3bniy5b5	434	35	by	by	IN
cord-344093-3bniy5b5	434	36	highly	highly	RB
cord-344093-3bniy5b5	434	37	pathogenic	pathogenic	JJ
cord-344093-3bniy5b5	434	38	influenza	influenza	NN
cord-344093-3bniy5b5	434	39	virus	virus	NN
cord-344093-3bniy5b5	434	40	Induction	induction	NN
cord-344093-3bniy5b5	434	41	of	of	IN
cord-344093-3bniy5b5	434	42	proinflammatory	proinflammatory	JJ
cord-344093-3bniy5b5	434	43	cytokines	cytokine	NNS
cord-344093-3bniy5b5	434	44	in	in	IN
cord-344093-3bniy5b5	434	45	human	human	JJ
cord-344093-3bniy5b5	434	46	macrophages	macrophage	NNS
cord-344093-3bniy5b5	434	47	by	by	IN
cord-344093-3bniy5b5	434	48	influenza	influenza	NN
cord-344093-3bniy5b5	434	49	A	a	NN
cord-344093-3bniy5b5	434	50	(	(	-LRB-
cord-344093-3bniy5b5	434	51	H5N1	H5N1	NNP
cord-344093-3bniy5b5	434	52	)	)	-RRB-
cord-344093-3bniy5b5	434	53	viruses	virus	NNS
cord-344093-3bniy5b5	434	54	:	:	:
cord-344093-3bniy5b5	435	1	a	a	DT
cord-344093-3bniy5b5	435	2	mechanism	mechanism	NN
cord-344093-3bniy5b5	435	3	for	for	IN
cord-344093-3bniy5b5	435	4	the	the	DT
cord-344093-3bniy5b5	435	5	unusual	unusual	JJ
cord-344093-3bniy5b5	435	6	severity	severity	NN
cord-344093-3bniy5b5	435	7	of	of	IN
cord-344093-3bniy5b5	435	8	human	human	JJ
cord-344093-3bniy5b5	435	9	disease	disease	NN
cord-344093-3bniy5b5	435	10	?	?	.
cord-344093-3bniy5b5	436	1	Re	Re	NNS
cord-344093-3bniy5b5	436	2	-	-	NN
cord-344093-3bniy5b5	436	3	emergence	emergence	NN
cord-344093-3bniy5b5	436	4	of	of	IN
cord-344093-3bniy5b5	436	5	fatal	fatal	JJ
cord-344093-3bniy5b5	436	6	human	human	JJ
cord-344093-3bniy5b5	436	7	influenza	influenza	NN
cord-344093-3bniy5b5	436	8	A	a	DT
cord-344093-3bniy5b5	436	9	subtype	subtype	NN
cord-344093-3bniy5b5	436	10	H5N1	H5N1	NNP
cord-344093-3bniy5b5	436	11	disease	disease	NN
cord-344093-3bniy5b5	436	12	Fatal	fatal	JJ
cord-344093-3bniy5b5	436	13	outcome	outcome	NN
cord-344093-3bniy5b5	436	14	of	of	IN
cord-344093-3bniy5b5	436	15	human	human	JJ
cord-344093-3bniy5b5	436	16	influenza	influenza	NN
cord-344093-3bniy5b5	436	17	A	a	NN
cord-344093-3bniy5b5	436	18	(	(	-LRB-
cord-344093-3bniy5b5	436	19	H5N1	H5N1	NNP
cord-344093-3bniy5b5	436	20	)	)	-RRB-
cord-344093-3bniy5b5	436	21	is	be	VBZ
cord-344093-3bniy5b5	436	22	associated	associate	VBN
cord-344093-3bniy5b5	436	23	with	with	IN
cord-344093-3bniy5b5	436	24	high	high	JJ
cord-344093-3bniy5b5	436	25	viral	viral	JJ
cord-344093-3bniy5b5	436	26	load	load	NN
cord-344093-3bniy5b5	436	27	and	and	CC
cord-344093-3bniy5b5	436	28	hypercytokinemia	hypercytokinemia	NN
cord-344093-3bniy5b5	436	29	Lethal	Lethal	NNP
cord-344093-3bniy5b5	436	30	H5N1	H5N1	NNP
cord-344093-3bniy5b5	436	31	influenza	influenza	NN
cord-344093-3bniy5b5	436	32	viruses	virus	NNS
cord-344093-3bniy5b5	436	33	escape	escape	VBP
cord-344093-3bniy5b5	436	34	host	host	NN
cord-344093-3bniy5b5	436	35	anti	anti	JJ
cord-344093-3bniy5b5	436	36	-	-	JJ
cord-344093-3bniy5b5	436	37	viral	viral	JJ
cord-344093-3bniy5b5	436	38	cytokine	cytokine	NN
cord-344093-3bniy5b5	436	39	responses	response	NNS
cord-344093-3bniy5b5	436	40	Highly	highly	RB
cord-344093-3bniy5b5	436	41	pathogenic	pathogenic	JJ
cord-344093-3bniy5b5	436	42	avian	avian	JJ
cord-344093-3bniy5b5	436	43	influenza	influenza	NN
cord-344093-3bniy5b5	436	44	H5N1	H5N1	NNP
cord-344093-3bniy5b5	436	45	viruses	virus	NNS
cord-344093-3bniy5b5	436	46	elicit	elicit	VBP
cord-344093-3bniy5b5	436	47	an	an	DT
cord-344093-3bniy5b5	436	48	attenuated	attenuated	JJ
cord-344093-3bniy5b5	436	49	type	type	NN
cord-344093-3bniy5b5	436	50	I	-PRON-	PRP
cord-344093-3bniy5b5	436	51	interferon	interferon	VBD
cord-344093-3bniy5b5	436	52	response	response	NN
cord-344093-3bniy5b5	436	53	in	in	IN
cord-344093-3bniy5b5	436	54	polarized	polarized	JJ
cord-344093-3bniy5b5	436	55	human	human	JJ
cord-344093-3bniy5b5	436	56	bronchial	bronchial	JJ
cord-344093-3bniy5b5	436	57	epithelial	epithelial	JJ
cord-344093-3bniy5b5	436	58	cells	cell	NNS
cord-344093-3bniy5b5	436	59	Cytochrome	cytochrome	NN
cord-344093-3bniy5b5	436	60	c	c	NN
cord-344093-3bniy5b5	436	61	and	and	CC
cord-344093-3bniy5b5	436	62	dATP	datp	JJ
cord-344093-3bniy5b5	436	63	-	-	HYPH
cord-344093-3bniy5b5	436	64	dependent	dependent	JJ
cord-344093-3bniy5b5	436	65	formation	formation	NN
cord-344093-3bniy5b5	436	66	of	of	IN
cord-344093-3bniy5b5	436	67	Apaf-1	Apaf-1	NNP
cord-344093-3bniy5b5	436	68	/	/	SYM
cord-344093-3bniy5b5	436	69	Caspase-9	Caspase-9	NNP
cord-344093-3bniy5b5	436	70	complex	complex	NN
cord-344093-3bniy5b5	436	71	initiates	initiate	VBZ
cord-344093-3bniy5b5	436	72	an	an	DT
cord-344093-3bniy5b5	436	73	apoptotic	apoptotic	JJ
cord-344093-3bniy5b5	436	74	protease	protease	NN
cord-344093-3bniy5b5	436	75	cascade	cascade	NN
cord-344093-3bniy5b5	436	76	Caspases	caspase	NNS
cord-344093-3bniy5b5	436	77	:	:	:
cord-344093-3bniy5b5	436	78	the	the	DT
cord-344093-3bniy5b5	436	79	executioners	executioner	NNS
cord-344093-3bniy5b5	436	80	of	of	IN
cord-344093-3bniy5b5	436	81	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	436	82	The	the	DT
cord-344093-3bniy5b5	436	83	TNF	TNF	NNP
cord-344093-3bniy5b5	436	84	and	and	CC
cord-344093-3bniy5b5	436	85	TNF	TNF	NNP
cord-344093-3bniy5b5	436	86	receptor	receptor	NN
cord-344093-3bniy5b5	436	87	superfamilies	superfamily	NNS
cord-344093-3bniy5b5	436	88	:	:	:
cord-344093-3bniy5b5	436	89	integrating	integrate	VBG
cord-344093-3bniy5b5	436	90	mammalian	mammalian	JJ
cord-344093-3bniy5b5	436	91	biology	biology	NN
cord-344093-3bniy5b5	436	92	Caspase	Caspase	NNP
cord-344093-3bniy5b5	436	93	functions	function	NNS
cord-344093-3bniy5b5	436	94	in	in	IN
cord-344093-3bniy5b5	436	95	cell	cell	NN
cord-344093-3bniy5b5	436	96	death	death	NN
cord-344093-3bniy5b5	436	97	and	and	CC
cord-344093-3bniy5b5	436	98	disease	disease	NN
cord-344093-3bniy5b5	436	99	Apoptosis	apoptosis	NN
cord-344093-3bniy5b5	436	100	and	and	CC
cord-344093-3bniy5b5	436	101	interferons	interferon	NNS
cord-344093-3bniy5b5	436	102	:	:	:
cord-344093-3bniy5b5	436	103	role	role	NN
cord-344093-3bniy5b5	436	104	of	of	IN
cord-344093-3bniy5b5	436	105	interferon	interferon	NN
cord-344093-3bniy5b5	436	106	-	-	HYPH
cord-344093-3bniy5b5	436	107	stimulated	stimulate	VBN
cord-344093-3bniy5b5	436	108	genes	gene	NNS
cord-344093-3bniy5b5	436	109	as	as	IN
cord-344093-3bniy5b5	436	110	mediators	mediator	NNS
cord-344093-3bniy5b5	436	111	of	of	IN
cord-344093-3bniy5b5	436	112	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	436	113	IRF-1	IRF-1	NNP
cord-344093-3bniy5b5	436	114	mediated	mediate	VBN
cord-344093-3bniy5b5	436	115	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	436	116	is	be	VBZ
cord-344093-3bniy5b5	437	1	FADD	FADD	NNP
cord-344093-3bniy5b5	437	2	and	and	CC
cord-344093-3bniy5b5	437	3	caspase	caspase	NN
cord-344093-3bniy5b5	437	4	8	8	CD
cord-344093-3bniy5b5	437	5	dependent	dependent	JJ
cord-344093-3bniy5b5	437	6	Caspase-4	Caspase-4	NNP
cord-344093-3bniy5b5	437	7	is	be	VBZ
cord-344093-3bniy5b5	437	8	required	require	VBN
cord-344093-3bniy5b5	437	9	for	for	IN
cord-344093-3bniy5b5	437	10	activation	activation	NN
cord-344093-3bniy5b5	437	11	of	of	IN
cord-344093-3bniy5b5	437	12	inflammasomes	inflammasomes	NNP
cord-344093-3bniy5b5	437	13	Type	Type	NNP
cord-344093-3bniy5b5	438	1	I	-PRON-	PRP
cord-344093-3bniy5b5	439	1	interferon	interferon	NN
cord-344093-3bniy5b5	439	2	:	:	:
cord-344093-3bniy5b5	439	3	friend	friend	NN
cord-344093-3bniy5b5	439	4	or	or	CC
cord-344093-3bniy5b5	439	5	foe	foe	NN
cord-344093-3bniy5b5	439	6	?	?	.
cord-344093-3bniy5b5	440	1	Viral	viral	JJ
cord-344093-3bniy5b5	440	2	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	440	3	is	be	VBZ
cord-344093-3bniy5b5	440	4	induced	induce	VBN
cord-344093-3bniy5b5	440	5	by	by	IN
cord-344093-3bniy5b5	440	6	IRF-3-mediated	irf-3-mediate	VBN
cord-344093-3bniy5b5	440	7	activation	activation	NN
cord-344093-3bniy5b5	440	8	of	of	IN
cord-344093-3bniy5b5	440	9	Bax	Bax	NNP
cord-344093-3bniy5b5	440	10	IRF-5	IRF-5	NNP
cord-344093-3bniy5b5	440	11	is	be	VBZ
cord-344093-3bniy5b5	440	12	a	a	DT
cord-344093-3bniy5b5	440	13	mediator	mediator	NN
cord-344093-3bniy5b5	440	14	of	of	IN
cord-344093-3bniy5b5	440	15	the	the	DT
cord-344093-3bniy5b5	440	16	death	death	NN
cord-344093-3bniy5b5	440	17	receptor	receptor	NN
cord-344093-3bniy5b5	440	18	-	-	HYPH
cord-344093-3bniy5b5	440	19	induced	induce	VBN
cord-344093-3bniy5b5	440	20	apoptotic	apoptotic	JJ
cord-344093-3bniy5b5	440	21	signaling	signal	VBG
cord-344093-3bniy5b5	440	22	pathway	pathway	NN
cord-344093-3bniy5b5	440	23	Proapoptotic	Proapoptotic	NNP
cord-344093-3bniy5b5	440	24	signaling	signal	VBG
cord-344093-3bniy5b5	440	25	induced	induce	VBN
cord-344093-3bniy5b5	440	26	by	by	IN
cord-344093-3bniy5b5	440	27	RIG	rig	NN
cord-344093-3bniy5b5	440	28	-	-	:
cord-344093-3bniy5b5	440	29	I	I	NNP
cord-344093-3bniy5b5	440	30	and	and	CC
cord-344093-3bniy5b5	440	31	MDA-5	MDA-5	NNP
cord-344093-3bniy5b5	440	32	results	result	NNS
cord-344093-3bniy5b5	440	33	in	in	IN
cord-344093-3bniy5b5	440	34	type	type	NN
cord-344093-3bniy5b5	441	1	I	-PRON-	PRP
cord-344093-3bniy5b5	442	1	interferon	interferon	NN
cord-344093-3bniy5b5	442	2	-	-	HYPH
cord-344093-3bniy5b5	442	3	independent	independent	JJ
cord-344093-3bniy5b5	442	4	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	442	5	in	in	IN
cord-344093-3bniy5b5	442	6	human	human	JJ
cord-344093-3bniy5b5	442	7	melanoma	melanoma	NN
cord-344093-3bniy5b5	442	8	cells	cell	NNS
cord-344093-3bniy5b5	443	1	Interferon	interferon	NN
cord-344093-3bniy5b5	443	2	action	action	NN
cord-344093-3bniy5b5	443	3	and	and	CC
cord-344093-3bniy5b5	443	4	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	443	5	are	be	VBP
cord-344093-3bniy5b5	443	6	defective	defective	JJ
cord-344093-3bniy5b5	443	7	in	in	IN
cord-344093-3bniy5b5	443	8	mice	mice	NN
cord-344093-3bniy5b5	443	9	devoid	devoid	JJ
cord-344093-3bniy5b5	443	10	of	of	IN
cord-344093-3bniy5b5	443	11	2	2	CD
cord-344093-3bniy5b5	443	12	'	'	''
cord-344093-3bniy5b5	443	13	,	,	.
cord-344093-3bniy5b5	444	1	5'-oligoadenylate	5'-oligoadenylate	CD
cord-344093-3bniy5b5	444	2	-	-	HYPH
cord-344093-3bniy5b5	444	3	dependent	dependent	JJ
cord-344093-3bniy5b5	444	4	RNase	rnase	NN
cord-344093-3bniy5b5	444	5	L	L	NNP
cord-344093-3bniy5b5	444	6	Interferon	Interferon	NNP
cord-344093-3bniy5b5	444	7	α	α	NN
cord-344093-3bniy5b5	444	8	augments	augment	VBZ
cord-344093-3bniy5b5	444	9	activation	activation	NN
cord-344093-3bniy5b5	444	10	-	-	HYPH
cord-344093-3bniy5b5	444	11	induced	induce	VBN
cord-344093-3bniy5b5	444	12	T	t	NN
cord-344093-3bniy5b5	444	13	cell	cell	NN
cord-344093-3bniy5b5	444	14	death	death	NN
cord-344093-3bniy5b5	444	15	by	by	IN
cord-344093-3bniy5b5	444	16	upregulation	upregulation	NN
cord-344093-3bniy5b5	444	17	of	of	IN
cord-344093-3bniy5b5	444	18	Fas	Fas	NNP
cord-344093-3bniy5b5	444	19	(	(	-LRB-
cord-344093-3bniy5b5	444	20	CD95	CD95	NNP
cord-344093-3bniy5b5	444	21	/	/	SYM
cord-344093-3bniy5b5	444	22	APO-1	APO-1	NNP
cord-344093-3bniy5b5	444	23	)	)	-RRB-
cord-344093-3bniy5b5	444	24	and	and	CC
cord-344093-3bniy5b5	445	1	Fas	Fas	NNP
cord-344093-3bniy5b5	445	2	ligand	ligand	NN
cord-344093-3bniy5b5	445	3	expression	expression	NN
cord-344093-3bniy5b5	445	4	Type	type	NN
cord-344093-3bniy5b5	445	5	-	-	:
cord-344093-3bniy5b5	445	6	I	-PRON-	PRP
cord-344093-3bniy5b5	445	7	interferon	interferon	NN
cord-344093-3bniy5b5	445	8	is	be	VBZ
cord-344093-3bniy5b5	445	9	critical	critical	JJ
cord-344093-3bniy5b5	445	10	for	for	IN
cord-344093-3bniy5b5	445	11	FasL	FasL	NNP
cord-344093-3bniy5b5	445	12	expression	expression	NN
cord-344093-3bniy5b5	445	13	on	on	IN
cord-344093-3bniy5b5	445	14	lung	lung	NN
cord-344093-3bniy5b5	445	15	cells	cell	NNS
cord-344093-3bniy5b5	445	16	to	to	TO
cord-344093-3bniy5b5	445	17	determine	determine	VB
cord-344093-3bniy5b5	445	18	the	the	DT
cord-344093-3bniy5b5	445	19	severity	severity	NN
cord-344093-3bniy5b5	445	20	of	of	IN
cord-344093-3bniy5b5	445	21	influenza	influenza	NN
cord-344093-3bniy5b5	445	22	Antiviral	antiviral	JJ
cord-344093-3bniy5b5	445	23	response	response	NN
cord-344093-3bniy5b5	445	24	by	by	IN
cord-344093-3bniy5b5	445	25	natural	natural	JJ
cord-344093-3bniy5b5	445	26	killer	killer	NN
cord-344093-3bniy5b5	445	27	cells	cell	NNS
cord-344093-3bniy5b5	445	28	through	through	IN
cord-344093-3bniy5b5	445	29	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	445	30	gene	gene	NN
cord-344093-3bniy5b5	445	31	induction	induction	NN
cord-344093-3bniy5b5	445	32	by	by	IN
cord-344093-3bniy5b5	445	33	IFN	IFN	NNP
cord-344093-3bniy5b5	445	34	-	-	HYPH
cord-344093-3bniy5b5	445	35	alpha	alpha	NNP
cord-344093-3bniy5b5	446	1	/beta	/beta	,
cord-344093-3bniy5b5	446	2	Interferoninduced	Interferoninduced	NNP
cord-344093-3bniy5b5	446	3	RIP1	RIP1	NNP
cord-344093-3bniy5b5	446	4	/	/	SYM
cord-344093-3bniy5b5	446	5	RIP3-mediated	rip3-mediate	VBN
cord-344093-3bniy5b5	446	6	necrosis	necrosis	NN
cord-344093-3bniy5b5	446	7	requires	require	VBZ
cord-344093-3bniy5b5	446	8	PKR	PKR	NNP
cord-344093-3bniy5b5	446	9	and	and	CC
cord-344093-3bniy5b5	446	10	is	be	VBZ
cord-344093-3bniy5b5	446	11	licensed	license	VBN
cord-344093-3bniy5b5	446	12	by	by	IN
cord-344093-3bniy5b5	446	13	FADD	FADD	NNP
cord-344093-3bniy5b5	446	14	and	and	CC
cord-344093-3bniy5b5	446	15	caspases	caspase	NNS
cord-344093-3bniy5b5	446	16	Type	type	NN
cord-344093-3bniy5b5	446	17	-	-	:
cord-344093-3bniy5b5	446	18	I	i	NN
cord-344093-3bniy5b5	447	1	interferon	interferon	NN
cord-344093-3bniy5b5	447	2	signaling	signal	VBG
cord-344093-3bniy5b5	447	3	through	through	IN
cord-344093-3bniy5b5	447	4	ISGF3	isgf3	NN
cord-344093-3bniy5b5	447	5	complex	complex	NN
cord-344093-3bniy5b5	447	6	is	be	VBZ
cord-344093-3bniy5b5	447	7	required	require	VBN
cord-344093-3bniy5b5	447	8	for	for	IN
cord-344093-3bniy5b5	447	9	sustained	sustained	JJ
cord-344093-3bniy5b5	447	10	Rip3	Rip3	NNP
cord-344093-3bniy5b5	447	11	activation	activation	NN
cord-344093-3bniy5b5	447	12	and	and	CC
cord-344093-3bniy5b5	447	13	necroptosis	necroptosis	NN
cord-344093-3bniy5b5	447	14	in	in	IN
cord-344093-3bniy5b5	447	15	macrophages	macrophage	NNS
cord-344093-3bniy5b5	447	16	Role	role	NN
cord-344093-3bniy5b5	447	17	of	of	IN
cord-344093-3bniy5b5	447	18	the	the	DT
cord-344093-3bniy5b5	447	19	mitochondrion	mitochondrion	NN
cord-344093-3bniy5b5	447	20	in	in	IN
cord-344093-3bniy5b5	447	21	programmed	program	VBN
cord-344093-3bniy5b5	447	22	necrosis	necrosis	NN
cord-344093-3bniy5b5	447	23	Necroptosis	Necroptosis	NNP
cord-344093-3bniy5b5	447	24	and	and	CC
cord-344093-3bniy5b5	447	25	its	-PRON-	PRP$
cord-344093-3bniy5b5	447	26	role	role	NN
cord-344093-3bniy5b5	447	27	in	in	IN
cord-344093-3bniy5b5	447	28	inflammation	inflammation	NN
cord-344093-3bniy5b5	447	29	DAI	DAI	NNP
cord-344093-3bniy5b5	448	1	senses	sense	NNS
cord-344093-3bniy5b5	448	2	influenza	influenza	VBP
cord-344093-3bniy5b5	448	3	A	a	DT
cord-344093-3bniy5b5	448	4	virus	virus	NN
cord-344093-3bniy5b5	448	5	genomic	genomic	JJ
cord-344093-3bniy5b5	448	6	RNA	RNA	NNP
cord-344093-3bniy5b5	448	7	and	and	CC
cord-344093-3bniy5b5	448	8	activates	activate	VBZ
cord-344093-3bniy5b5	448	9	RIPK3-dependent	ripk3-dependent	NN
cord-344093-3bniy5b5	448	10	cell	cell	NN
cord-344093-3bniy5b5	448	11	death	death	NN
cord-344093-3bniy5b5	449	1	The	the	DT
cord-344093-3bniy5b5	449	2	acute	acute	JJ
cord-344093-3bniy5b5	449	3	respiratory	respiratory	JJ
cord-344093-3bniy5b5	449	4	distress	distress	NN
cord-344093-3bniy5b5	449	5	syndrome	syndrome	NN
cord-344093-3bniy5b5	449	6	:	:	:
cord-344093-3bniy5b5	449	7	mechanisms	mechanism	NNS
cord-344093-3bniy5b5	449	8	and	and	CC
cord-344093-3bniy5b5	449	9	perspective	perspective	VB
cord-344093-3bniy5b5	449	10	therapeutic	therapeutic	JJ
cord-344093-3bniy5b5	449	11	approaches	approach	NNS
cord-344093-3bniy5b5	449	12	The	the	DT
cord-344093-3bniy5b5	449	13	acute	acute	JJ
cord-344093-3bniy5b5	449	14	respiratory	respiratory	JJ
cord-344093-3bniy5b5	449	15	distress	distress	NN
cord-344093-3bniy5b5	449	16	syndrome	syndrome	NN
cord-344093-3bniy5b5	450	1	Interferon	interferon	NN
cord-344093-3bniy5b5	450	2	-	-	HYPH
cord-344093-3bniy5b5	450	3	producing	produce	VBG
cord-344093-3bniy5b5	450	4	killer	killer	NN
cord-344093-3bniy5b5	450	5	dendritic	dendritic	JJ
cord-344093-3bniy5b5	450	6	cells	cell	NNS
cord-344093-3bniy5b5	450	7	provide	provide	VBP
cord-344093-3bniy5b5	450	8	a	a	DT
cord-344093-3bniy5b5	450	9	link	link	NN
cord-344093-3bniy5b5	450	10	between	between	IN
cord-344093-3bniy5b5	450	11	innate	innate	JJ
cord-344093-3bniy5b5	450	12	and	and	CC
cord-344093-3bniy5b5	450	13	adaptive	adaptive	JJ
cord-344093-3bniy5b5	450	14	immunity	immunity	NN
cord-344093-3bniy5b5	451	1	The	the	DT
cord-344093-3bniy5b5	451	2	biology	biology	NN
cord-344093-3bniy5b5	451	3	of	of	IN
cord-344093-3bniy5b5	451	4	TRAIL	trail	NN
cord-344093-3bniy5b5	451	5	and	and	CC
cord-344093-3bniy5b5	451	6	the	the	DT
cord-344093-3bniy5b5	451	7	role	role	NN
cord-344093-3bniy5b5	451	8	of	of	IN
cord-344093-3bniy5b5	451	9	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	451	10	-	-	HYPH
cord-344093-3bniy5b5	451	11	based	base	VBN
cord-344093-3bniy5b5	451	12	therapeutics	therapeutic	NNS
cord-344093-3bniy5b5	451	13	in	in	IN
cord-344093-3bniy5b5	451	14	infectious	infectious	JJ
cord-344093-3bniy5b5	451	15	diseases	disease	NNS
cord-344093-3bniy5b5	451	16	Regulation	regulation	NN
cord-344093-3bniy5b5	451	17	of	of	IN
cord-344093-3bniy5b5	451	18	soluble	soluble	JJ
cord-344093-3bniy5b5	451	19	and	and	CC
cord-344093-3bniy5b5	451	20	surface	surface	NN
cord-344093-3bniy5b5	451	21	-	-	HYPH
cord-344093-3bniy5b5	451	22	bound	bind	VBN
cord-344093-3bniy5b5	451	23	TRAIL	trail	NN
cord-344093-3bniy5b5	451	24	in	in	IN
cord-344093-3bniy5b5	451	25	human	human	JJ
cord-344093-3bniy5b5	451	26	T	t	NN
cord-344093-3bniy5b5	451	27	cells	cell	NNS
cord-344093-3bniy5b5	451	28	,	,	,
cord-344093-3bniy5b5	451	29	B	b	NN
cord-344093-3bniy5b5	451	30	cells	cell	NNS
cord-344093-3bniy5b5	451	31	,	,	,
cord-344093-3bniy5b5	451	32	and	and	CC
cord-344093-3bniy5b5	451	33	monocytes	monocyte	VBZ
cord-344093-3bniy5b5	451	34	IFN	IFN	NNP
cord-344093-3bniy5b5	451	35	-	-	HYPH
cord-344093-3bniy5b5	451	36	gamma	gamma	NNP
cord-344093-3bniy5b5	451	37	mediates	mediate	VBZ
cord-344093-3bniy5b5	451	38	a	a	DT
cord-344093-3bniy5b5	451	39	novel	novel	JJ
cord-344093-3bniy5b5	451	40	antiviral	antiviral	JJ
cord-344093-3bniy5b5	451	41	activity	activity	NN
cord-344093-3bniy5b5	451	42	through	through	IN
cord-344093-3bniy5b5	451	43	dynamic	dynamic	JJ
cord-344093-3bniy5b5	451	44	modulation	modulation	NN
cord-344093-3bniy5b5	451	45	of	of	IN
cord-344093-3bniy5b5	451	46	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	451	47	and	and	CC
cord-344093-3bniy5b5	451	48	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	451	49	receptor	receptor	NN
cord-344093-3bniy5b5	451	50	expression	expression	NN
cord-344093-3bniy5b5	452	1	Club	club	NN
cord-344093-3bniy5b5	452	2	cells	cell	NNS
cord-344093-3bniy5b5	452	3	inhibit	inhibit	VBP
cord-344093-3bniy5b5	452	4	alveolar	alveolar	JJ
cord-344093-3bniy5b5	452	5	epithelial	epithelial	NN
cord-344093-3bniy5b5	452	6	wound	wound	NN
cord-344093-3bniy5b5	452	7	repair	repair	NN
cord-344093-3bniy5b5	452	8	via	via	IN
cord-344093-3bniy5b5	452	9	TRAIL	trail	NN
cord-344093-3bniy5b5	452	10	-	-	HYPH
cord-344093-3bniy5b5	452	11	dependent	dependent	JJ
cord-344093-3bniy5b5	452	12	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	453	1	Alveolar	alveolar	JJ
cord-344093-3bniy5b5	453	2	epithelial	epithelial	JJ
cord-344093-3bniy5b5	453	3	cells	cell	NNS
cord-344093-3bniy5b5	453	4	in	in	IN
cord-344093-3bniy5b5	453	5	idiopathic	idiopathic	JJ
cord-344093-3bniy5b5	453	6	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	453	7	fibrosis	fibrosis	NN
cord-344093-3bniy5b5	453	8	display	display	NN
cord-344093-3bniy5b5	453	9	upregulation	upregulation	NN
cord-344093-3bniy5b5	453	10	of	of	IN
cord-344093-3bniy5b5	453	11	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	453	12	,	,	,
cord-344093-3bniy5b5	453	13	DR4	DR4	NNP
cord-344093-3bniy5b5	453	14	and	and	CC
cord-344093-3bniy5b5	453	15	DR5	DR5	NNP
cord-344093-3bniy5b5	453	16	expression	expression	NN
cord-344093-3bniy5b5	453	17	with	with	IN
cord-344093-3bniy5b5	453	18	simultaneous	simultaneous	JJ
cord-344093-3bniy5b5	453	19	preferential	preferential	JJ
cord-344093-3bniy5b5	453	20	over	over	IN
cord-344093-3bniy5b5	453	21	-	-	HYPH
cord-344093-3bniy5b5	453	22	expression	expression	NN
cord-344093-3bniy5b5	453	23	of	of	IN
cord-344093-3bniy5b5	453	24	pro	pro	JJ
cord-344093-3bniy5b5	453	25	-	-	JJ
cord-344093-3bniy5b5	453	26	apoptotic	apoptotic	JJ
cord-344093-3bniy5b5	453	27	marker	marker	NN
cord-344093-3bniy5b5	453	28	p53	p53	NN
cord-344093-3bniy5b5	453	29	Highly	highly	RB
cord-344093-3bniy5b5	453	30	pathogenic	pathogenic	JJ
cord-344093-3bniy5b5	453	31	avian	avian	JJ
cord-344093-3bniy5b5	453	32	influenza	influenza	NN
cord-344093-3bniy5b5	453	33	H5N1	H5N1	NNP
cord-344093-3bniy5b5	453	34	virus	virus	NN
cord-344093-3bniy5b5	453	35	delays	delay	VBZ
cord-344093-3bniy5b5	453	36	apoptotic	apoptotic	JJ
cord-344093-3bniy5b5	453	37	responses	response	NNS
cord-344093-3bniy5b5	453	38	via	via	IN
cord-344093-3bniy5b5	453	39	activation	activation	NN
cord-344093-3bniy5b5	453	40	of	of	IN
cord-344093-3bniy5b5	453	41	STAT3	STAT3	NNP
cord-344093-3bniy5b5	453	42	Identification	identification	NN
cord-344093-3bniy5b5	453	43	and	and	CC
cord-344093-3bniy5b5	453	44	characterization	characterization	NN
cord-344093-3bniy5b5	453	45	of	of	IN
cord-344093-3bniy5b5	453	46	a	a	DT
cord-344093-3bniy5b5	453	47	new	new	JJ
cord-344093-3bniy5b5	453	48	member	member	NN
cord-344093-3bniy5b5	453	49	of	of	IN
cord-344093-3bniy5b5	453	50	the	the	DT
cord-344093-3bniy5b5	453	51	TNF	TNF	NNP
cord-344093-3bniy5b5	453	52	Family	Family	NNP
cord-344093-3bniy5b5	453	53	that	that	WDT
cord-344093-3bniy5b5	453	54	induces	induce	VBZ
cord-344093-3bniy5b5	453	55	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	453	56	Membranebound	Membranebound	NNP
cord-344093-3bniy5b5	453	57	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	453	58	supplements	supplement	VBZ
cord-344093-3bniy5b5	453	59	natural	natural	JJ
cord-344093-3bniy5b5	453	60	killer	killer	NN
cord-344093-3bniy5b5	453	61	cell	cell	NN
cord-344093-3bniy5b5	453	62	cytotoxicity	cytotoxicity	NN
cord-344093-3bniy5b5	453	63	against	against	IN
cord-344093-3bniy5b5	453	64	neuroblastoma	neuroblastoma	NN
cord-344093-3bniy5b5	453	65	cells	cell	NNS
cord-344093-3bniy5b5	454	1	Following	follow	VBG
cord-344093-3bniy5b5	454	2	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	454	3	's	's	POS
cord-344093-3bniy5b5	454	4	path	path	NN
cord-344093-3bniy5b5	454	5	in	in	IN
cord-344093-3bniy5b5	454	6	the	the	DT
cord-344093-3bniy5b5	454	7	immune	immune	JJ
cord-344093-3bniy5b5	454	8	system	system	NN
cord-344093-3bniy5b5	454	9	Apo2L	Apo2L	NNS
cord-344093-3bniy5b5	454	10	/	/	SYM
cord-344093-3bniy5b5	454	11	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	454	12	and	and	CC
cord-344093-3bniy5b5	454	13	its	-PRON-	PRP$
cord-344093-3bniy5b5	454	14	death	death	NN
cord-344093-3bniy5b5	454	15	and	and	CC
cord-344093-3bniy5b5	454	16	decoy	decoy	NN
cord-344093-3bniy5b5	454	17	receptors	receptor	NNS
cord-344093-3bniy5b5	454	18	Molecular	molecular	JJ
cord-344093-3bniy5b5	454	19	cloning	clone	VBG
cord-344093-3bniy5b5	454	20	and	and	CC
cord-344093-3bniy5b5	454	21	functional	functional	JJ
cord-344093-3bniy5b5	454	22	analysis	analysis	NN
cord-344093-3bniy5b5	454	23	of	of	IN
cord-344093-3bniy5b5	454	24	the	the	DT
cord-344093-3bniy5b5	454	25	mouse	mouse	NN
cord-344093-3bniy5b5	454	26	homologue	homologue	NN
cord-344093-3bniy5b5	454	27	of	of	IN
cord-344093-3bniy5b5	454	28	the	the	DT
cord-344093-3bniy5b5	454	29	KILLER	KILLER	NNP
cord-344093-3bniy5b5	454	30	/	/	SYM
cord-344093-3bniy5b5	454	31	DR5	DR5	NNP
cord-344093-3bniy5b5	454	32	tumor	tumor	NN
cord-344093-3bniy5b5	454	33	necrosis	necrosis	NN
cord-344093-3bniy5b5	454	34	factor	factor	NN
cord-344093-3bniy5b5	454	35	-	-	HYPH
cord-344093-3bniy5b5	454	36	related	relate	VBN
cord-344093-3bniy5b5	454	37	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	454	38	-	-	HYPH
cord-344093-3bniy5b5	454	39	inducing	induce	VBG
cord-344093-3bniy5b5	454	40	ligand	ligand	NN
cord-344093-3bniy5b5	455	1	(	(	-LRB-
cord-344093-3bniy5b5	455	2	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	455	3	)	)	-RRB-
cord-344093-3bniy5b5	455	4	death	death	NN
cord-344093-3bniy5b5	455	5	receptor	receptor	NN
cord-344093-3bniy5b5	455	6	Tissue	tissue	NN
cord-344093-3bniy5b5	455	7	distribution	distribution	NN
cord-344093-3bniy5b5	455	8	of	of	IN
cord-344093-3bniy5b5	455	9	the	the	DT
cord-344093-3bniy5b5	455	10	death	death	NN
cord-344093-3bniy5b5	455	11	ligand	ligand	NN
cord-344093-3bniy5b5	455	12	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	455	13	and	and	CC
cord-344093-3bniy5b5	455	14	its	-PRON-	PRP$
cord-344093-3bniy5b5	455	15	receptors	receptor	NNS
cord-344093-3bniy5b5	455	16	Potential	potential	JJ
cord-344093-3bniy5b5	455	17	role	role	NN
cord-344093-3bniy5b5	455	18	of	of	IN
cord-344093-3bniy5b5	455	19	soluble	soluble	JJ
cord-344093-3bniy5b5	455	20	TRAIL	trail	NN
cord-344093-3bniy5b5	455	21	in	in	IN
cord-344093-3bniy5b5	455	22	epithelial	epithelial	JJ
cord-344093-3bniy5b5	455	23	injury	injury	NN
cord-344093-3bniy5b5	455	24	in	in	IN
cord-344093-3bniy5b5	455	25	children	child	NNS
cord-344093-3bniy5b5	455	26	with	with	IN
cord-344093-3bniy5b5	455	27	severe	severe	JJ
cord-344093-3bniy5b5	455	28	RSV	RSV	NNP
cord-344093-3bniy5b5	455	29	infection	infection	NN
cord-344093-3bniy5b5	455	30	Expression	expression	NN
cord-344093-3bniy5b5	455	31	of	of	IN
cord-344093-3bniy5b5	455	32	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	455	33	and	and	CC
cord-344093-3bniy5b5	455	34	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	455	35	receptors	receptor	NNS
cord-344093-3bniy5b5	455	36	in	in	IN
cord-344093-3bniy5b5	455	37	colon	colon	NN
cord-344093-3bniy5b5	455	38	carcinoma	carcinoma	NN
cord-344093-3bniy5b5	455	39	:	:	:
cord-344093-3bniy5b5	455	40	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	455	41	-	-	HYPH
cord-344093-3bniy5b5	455	42	R1	R1	NNP
cord-344093-3bniy5b5	455	43	is	be	VBZ
cord-344093-3bniy5b5	455	44	an	an	DT
cord-344093-3bniy5b5	455	45	independent	independent	JJ
cord-344093-3bniy5b5	455	46	prognostic	prognostic	JJ
cord-344093-3bniy5b5	455	47	parameter	parameter	NN
cord-344093-3bniy5b5	455	48	Identification	identification	NN
cord-344093-3bniy5b5	455	49	of	of	IN
cord-344093-3bniy5b5	455	50	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	455	51	as	as	IN
cord-344093-3bniy5b5	455	52	an	an	DT
cord-344093-3bniy5b5	455	53	interferon	interferon	NN
cord-344093-3bniy5b5	455	54	regulatory	regulatory	JJ
cord-344093-3bniy5b5	455	55	factor	factor	NN
cord-344093-3bniy5b5	455	56	3	3	CD
cord-344093-3bniy5b5	455	57	transcriptional	transcriptional	NN
cord-344093-3bniy5b5	455	58	target	target	NN
cord-344093-3bniy5b5	455	59	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	455	60	receptors	receptor	NNS
cord-344093-3bniy5b5	455	61	1	1	CD
cord-344093-3bniy5b5	455	62	(	(	-LRB-
cord-344093-3bniy5b5	455	63	DR4	DR4	NNP
cord-344093-3bniy5b5	455	64	)	)	-RRB-
cord-344093-3bniy5b5	455	65	and	and	CC
cord-344093-3bniy5b5	455	66	2	2	LS
cord-344093-3bniy5b5	455	67	(	(	-LRB-
cord-344093-3bniy5b5	455	68	DR5	DR5	NNP
cord-344093-3bniy5b5	455	69	)	)	-RRB-
cord-344093-3bniy5b5	455	70	signal	signal	JJ
cord-344093-3bniy5b5	455	71	FADD	FADD	NNP
cord-344093-3bniy5b5	455	72	-	-	HYPH
cord-344093-3bniy5b5	455	73	dependent	dependent	JJ
cord-344093-3bniy5b5	455	74	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	455	75	and	and	CC
cord-344093-3bniy5b5	455	76	activate	activate	VB
cord-344093-3bniy5b5	455	77	NF	NF	NNP
cord-344093-3bniy5b5	455	78	-	-	HYPH
cord-344093-3bniy5b5	455	79	kappaB	kappaB	NNP
cord-344093-3bniy5b5	455	80	Death	Death	NNP
cord-344093-3bniy5b5	455	81	receptor	receptor	NN
cord-344093-3bniy5b5	455	82	5	5	CD
cord-344093-3bniy5b5	455	83	,	,	,
cord-344093-3bniy5b5	455	84	a	a	DT
cord-344093-3bniy5b5	455	85	new	new	JJ
cord-344093-3bniy5b5	455	86	member	member	NN
cord-344093-3bniy5b5	455	87	of	of	IN
cord-344093-3bniy5b5	455	88	the	the	DT
cord-344093-3bniy5b5	455	89	TNFR	TNFR	NNP
cord-344093-3bniy5b5	455	90	family	family	NN
cord-344093-3bniy5b5	455	91	,	,	,
cord-344093-3bniy5b5	455	92	and	and	CC
cord-344093-3bniy5b5	455	93	DR4	dr4	NN
cord-344093-3bniy5b5	455	94	induce	induce	VB
cord-344093-3bniy5b5	455	95	FADDdependent	fadddependent	NN
cord-344093-3bniy5b5	455	96	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	455	97	and	and	CC
cord-344093-3bniy5b5	455	98	activate	activate	VB
cord-344093-3bniy5b5	455	99	the	the	DT
cord-344093-3bniy5b5	455	100	NF	NF	NNP
cord-344093-3bniy5b5	455	101	-	-	HYPH
cord-344093-3bniy5b5	455	102	kappaB	kappaB	NNP
cord-344093-3bniy5b5	455	103	pathway	pathway	NN
cord-344093-3bniy5b5	455	104	Caspases	Caspases	NNP
cord-344093-3bniy5b5	455	105	:	:	:
cord-344093-3bniy5b5	455	106	the	the	DT
cord-344093-3bniy5b5	455	107	enzymes	enzyme	NNS
cord-344093-3bniy5b5	455	108	of	of	IN
cord-344093-3bniy5b5	455	109	death	death	NN
cord-344093-3bniy5b5	456	1	The	the	DT
cord-344093-3bniy5b5	456	2	40-kDa	40-kda	CD
cord-344093-3bniy5b5	456	3	subunit	subunit	NN
cord-344093-3bniy5b5	456	4	of	of	IN
cord-344093-3bniy5b5	456	5	DNA	dna	NN
cord-344093-3bniy5b5	456	6	fragmentation	fragmentation	NN
cord-344093-3bniy5b5	456	7	factor	factor	NN
cord-344093-3bniy5b5	456	8	induces	induce	VBZ
cord-344093-3bniy5b5	456	9	DNA	dna	NN
cord-344093-3bniy5b5	456	10	fragmentation	fragmentation	NN
cord-344093-3bniy5b5	456	11	and	and	CC
cord-344093-3bniy5b5	456	12	chromatin	chromatin	NN
cord-344093-3bniy5b5	456	13	condensation	condensation	NN
cord-344093-3bniy5b5	456	14	during	during	IN
cord-344093-3bniy5b5	456	15	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	457	1	The	the	DT
cord-344093-3bniy5b5	457	2	TRAIL	trail	NN
cord-344093-3bniy5b5	457	3	to	to	IN
cord-344093-3bniy5b5	457	4	viral	viral	JJ
cord-344093-3bniy5b5	457	5	pathogenesis	pathogenesis	NN
cord-344093-3bniy5b5	457	6	:	:	:
cord-344093-3bniy5b5	458	1	the	the	DT
cord-344093-3bniy5b5	458	2	good	good	NN
cord-344093-3bniy5b5	458	3	,	,	,
cord-344093-3bniy5b5	458	4	the	the	DT
cord-344093-3bniy5b5	458	5	bad	bad	JJ
cord-344093-3bniy5b5	458	6	and	and	CC
cord-344093-3bniy5b5	458	7	the	the	DT
cord-344093-3bniy5b5	458	8	ugly	ugly	JJ
cord-344093-3bniy5b5	458	9	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	458	10	induces	induce	VBZ
cord-344093-3bniy5b5	458	11	necroptosis	necroptosis	NNP
cord-344093-3bniy5b5	458	12	involving	involve	VBG
cord-344093-3bniy5b5	458	13	RIPK1	RIPK1	NNP
cord-344093-3bniy5b5	458	14	/	/	SYM
cord-344093-3bniy5b5	458	15	RIPK3-dependent	ripk3-dependent	NN
cord-344093-3bniy5b5	458	16	PARP-1	PARP-1	NNP
cord-344093-3bniy5b5	458	17	activation	activation	NN
cord-344093-3bniy5b5	458	18	Cellular	cellular	JJ
cord-344093-3bniy5b5	458	19	inhibitor	inhibitor	NN
cord-344093-3bniy5b5	458	20	of	of	IN
cord-344093-3bniy5b5	458	21	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	458	22	protein	protein	NN
cord-344093-3bniy5b5	458	23	cIAP2	ciap2	NN
cord-344093-3bniy5b5	458	24	protects	protect	VBZ
cord-344093-3bniy5b5	458	25	against	against	IN
cord-344093-3bniy5b5	458	26	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	458	27	tissue	tissue	NN
cord-344093-3bniy5b5	458	28	necrosis	necrosis	NN
cord-344093-3bniy5b5	458	29	during	during	IN
cord-344093-3bniy5b5	458	30	influenza	influenza	NN
cord-344093-3bniy5b5	458	31	virus	virus	NN
cord-344093-3bniy5b5	458	32	infection	infection	NN
cord-344093-3bniy5b5	458	33	to	to	TO
cord-344093-3bniy5b5	458	34	promote	promote	VB
cord-344093-3bniy5b5	458	35	host	host	NN
cord-344093-3bniy5b5	458	36	survival	survival	NN
cord-344093-3bniy5b5	459	1	RIPK3	RIPK3	NNP
cord-344093-3bniy5b5	459	2	activates	activate	VBZ
cord-344093-3bniy5b5	459	3	parallel	parallel	JJ
cord-344093-3bniy5b5	459	4	pathways	pathway	NNS
cord-344093-3bniy5b5	459	5	of	of	IN
cord-344093-3bniy5b5	459	6	MLKL	MLKL	NNP
cord-344093-3bniy5b5	459	7	-	-	HYPH
cord-344093-3bniy5b5	459	8	driven	drive	VBN
cord-344093-3bniy5b5	459	9	necroptosis	necroptosis	NN
cord-344093-3bniy5b5	459	10	and	and	CC
cord-344093-3bniy5b5	459	11	FADDmediated	faddmediate	VBN
cord-344093-3bniy5b5	459	12	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	459	13	to	to	TO
cord-344093-3bniy5b5	459	14	protect	protect	VB
cord-344093-3bniy5b5	459	15	against	against	IN
cord-344093-3bniy5b5	459	16	influenza	influenza	NN
cord-344093-3bniy5b5	459	17	A	a	DT
cord-344093-3bniy5b5	459	18	virus	virus	NN
cord-344093-3bniy5b5	459	19	Autophagy	autophagy	NN
cord-344093-3bniy5b5	459	20	,	,	,
cord-344093-3bniy5b5	459	21	antiviral	antiviral	JJ
cord-344093-3bniy5b5	459	22	immunity	immunity	NN
cord-344093-3bniy5b5	459	23	,	,	,
cord-344093-3bniy5b5	459	24	and	and	CC
cord-344093-3bniy5b5	459	25	viral	viral	JJ
cord-344093-3bniy5b5	459	26	countermeasures	countermeasure	NNS
cord-344093-3bniy5b5	460	1	The	the	DT
cord-344093-3bniy5b5	460	2	autophagy	autophagy	NN
cord-344093-3bniy5b5	460	3	machinery	machinery	NN
cord-344093-3bniy5b5	460	4	controls	control	VBZ
cord-344093-3bniy5b5	460	5	cell	cell	NN
cord-344093-3bniy5b5	460	6	death	death	NN
cord-344093-3bniy5b5	460	7	switching	switch	VBG
cord-344093-3bniy5b5	460	8	between	between	IN
cord-344093-3bniy5b5	460	9	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	460	10	and	and	CC
cord-344093-3bniy5b5	460	11	necroptosis	necroptosis	NNP
cord-344093-3bniy5b5	460	12	Attenuation	Attenuation	NNP
cord-344093-3bniy5b5	460	13	of	of	IN
cord-344093-3bniy5b5	460	14	TNFSF10/	TNFSF10/	NNP
cord-344093-3bniy5b5	460	15	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	460	16	-	-	HYPH
cord-344093-3bniy5b5	460	17	induced	induce	VBN
cord-344093-3bniy5b5	460	18	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	460	19	by	by	IN
cord-344093-3bniy5b5	460	20	an	an	DT
cord-344093-3bniy5b5	460	21	autophagic	autophagic	NNP
cord-344093-3bniy5b5	460	22	survival	survival	NN
cord-344093-3bniy5b5	460	23	pathway	pathway	NN
cord-344093-3bniy5b5	460	24	involving	involve	VBG
cord-344093-3bniy5b5	460	25	TRAF2-and	traf2-and	JJ
cord-344093-3bniy5b5	460	26	RIPK1	ripk1	JJ
cord-344093-3bniy5b5	461	1	/	/	NFP
cord-344093-3bniy5b5	462	1	RIP1-mediated	RIP1-mediated	NNP
cord-344093-3bniy5b5	463	1	MAPK8	MAPK8	NNP
cord-344093-3bniy5b5	463	2	/	/	SYM
cord-344093-3bniy5b5	463	3	JNK	JNK	NNP
cord-344093-3bniy5b5	463	4	activation	activation	NN
cord-344093-3bniy5b5	464	1	Molecular	molecular	JJ
cord-344093-3bniy5b5	464	2	determinants	determinant	NNS
cord-344093-3bniy5b5	464	3	of	of	IN
cord-344093-3bniy5b5	464	4	kinase	kinase	NN
cord-344093-3bniy5b5	464	5	pathway	pathway	NN
cord-344093-3bniy5b5	464	6	activation	activation	NN
cord-344093-3bniy5b5	464	7	by	by	IN
cord-344093-3bniy5b5	464	8	Apo2	Apo2	NNP
cord-344093-3bniy5b5	464	9	ligand/	ligand/	NNP
cord-344093-3bniy5b5	464	10	tumor	tumor	NN
cord-344093-3bniy5b5	464	11	necrosis	necrosis	NN
cord-344093-3bniy5b5	464	12	factor	factor	NN
cord-344093-3bniy5b5	464	13	-	-	HYPH
cord-344093-3bniy5b5	464	14	related	relate	VBN
cord-344093-3bniy5b5	464	15	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	464	16	-	-	HYPH
cord-344093-3bniy5b5	464	17	inducing	induce	VBG
cord-344093-3bniy5b5	464	18	ligand	ligand	NN
cord-344093-3bniy5b5	465	1	TAK1	TAK1	NNP
cord-344093-3bniy5b5	465	2	Is	be	VBZ
cord-344093-3bniy5b5	465	3	required	require	VBN
cord-344093-3bniy5b5	465	4	for	for	IN
cord-344093-3bniy5b5	465	5	survival	survival	NN
cord-344093-3bniy5b5	465	6	of	of	IN
cord-344093-3bniy5b5	465	7	mouse	mouse	NN
cord-344093-3bniy5b5	465	8	fibroblasts	fibroblast	NNS
cord-344093-3bniy5b5	465	9	treated	treat	VBN
cord-344093-3bniy5b5	465	10	with	with	IN
cord-344093-3bniy5b5	465	11	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	465	12	,	,	,
cord-344093-3bniy5b5	465	13	and	and	CC
cord-344093-3bniy5b5	465	14	does	do	VBZ
cord-344093-3bniy5b5	465	15	so	so	RB
cord-344093-3bniy5b5	465	16	by	by	IN
cord-344093-3bniy5b5	465	17	NF	NF	NNP
cord-344093-3bniy5b5	465	18	-	-	HYPH
cord-344093-3bniy5b5	465	19	κB	κB	NNP
cord-344093-3bniy5b5	465	20	dependent	dependent	JJ
cord-344093-3bniy5b5	465	21	induction	induction	NN
cord-344093-3bniy5b5	465	22	of	of	IN
cord-344093-3bniy5b5	465	23	cFLIPL	cFLIPL	NNP
cord-344093-3bniy5b5	465	24	TAK1	TAK1	NNP
cord-344093-3bniy5b5	465	25	activates	activate	VBZ
cord-344093-3bniy5b5	465	26	AMPK	AMPK	NNP
cord-344093-3bniy5b5	465	27	-	-	HYPH
cord-344093-3bniy5b5	465	28	dependent	dependent	JJ
cord-344093-3bniy5b5	465	29	cytoprotective	cytoprotective	JJ
cord-344093-3bniy5b5	465	30	autophagy	autophagy	NN
cord-344093-3bniy5b5	465	31	in	in	IN
cord-344093-3bniy5b5	465	32	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	465	33	-	-	HYPH
cord-344093-3bniy5b5	465	34	treated	treat	VBN
cord-344093-3bniy5b5	465	35	epithelial	epithelial	JJ
cord-344093-3bniy5b5	465	36	cells	cell	NNS
cord-344093-3bniy5b5	465	37	Autophagic	Autophagic	NNP
cord-344093-3bniy5b5	465	38	degradation	degradation	NN
cord-344093-3bniy5b5	465	39	of	of	IN
cord-344093-3bniy5b5	465	40	active	active	JJ
cord-344093-3bniy5b5	465	41	caspase-8	caspase-8	NNP
cord-344093-3bniy5b5	465	42	Autophagy	Autophagy	NNP
cord-344093-3bniy5b5	465	43	suppresses	suppress	VBZ
cord-344093-3bniy5b5	465	44	RIP	rip	NN
cord-344093-3bniy5b5	465	45	kinase	kinase	NN
cord-344093-3bniy5b5	465	46	-	-	HYPH
cord-344093-3bniy5b5	465	47	dependent	dependent	JJ
cord-344093-3bniy5b5	465	48	necrosis	necrosis	NN
cord-344093-3bniy5b5	465	49	enabling	enable	VBG
cord-344093-3bniy5b5	465	50	survival	survival	NN
cord-344093-3bniy5b5	465	51	to	to	IN
cord-344093-3bniy5b5	465	52	mTOR	mTOR	NNP
cord-344093-3bniy5b5	465	53	inhibition	inhibition	NN
cord-344093-3bniy5b5	465	54	Caspase	Caspase	NNP
cord-344093-3bniy5b5	465	55	-	-	HYPH
cord-344093-3bniy5b5	465	56	mediated	mediate	VBN
cord-344093-3bniy5b5	465	57	crosstalk	crosstalk	NN
cord-344093-3bniy5b5	465	58	between	between	IN
cord-344093-3bniy5b5	465	59	autophagy	autophagy	NN
cord-344093-3bniy5b5	465	60	and	and	CC
cord-344093-3bniy5b5	465	61	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	465	62	:	:	:
cord-344093-3bniy5b5	465	63	mutual	mutual	JJ
cord-344093-3bniy5b5	465	64	adjustment	adjustment	NN
cord-344093-3bniy5b5	465	65	or	or	CC
cord-344093-3bniy5b5	465	66	matter	matter	NN
cord-344093-3bniy5b5	465	67	of	of	IN
cord-344093-3bniy5b5	465	68	dominance	dominance	NN
cord-344093-3bniy5b5	465	69	Autosis	Autosis	NNP
cord-344093-3bniy5b5	465	70	and	and	CC
cord-344093-3bniy5b5	465	71	autophagic	autophagic	JJ
cord-344093-3bniy5b5	465	72	cell	cell	NN
cord-344093-3bniy5b5	465	73	death	death	NN
cord-344093-3bniy5b5	465	74	:	:	:
cord-344093-3bniy5b5	465	75	the	the	DT
cord-344093-3bniy5b5	465	76	dark	dark	JJ
cord-344093-3bniy5b5	465	77	side	side	NN
cord-344093-3bniy5b5	465	78	of	of	IN
cord-344093-3bniy5b5	465	79	autophagy	autophagy	NN
cord-344093-3bniy5b5	465	80	Distinct	distinct	JJ
cord-344093-3bniy5b5	465	81	roles	role	NNS
cord-344093-3bniy5b5	465	82	of	of	IN
cord-344093-3bniy5b5	465	83	TNF	tnf	NN
cord-344093-3bniy5b5	465	84	-	-	HYPH
cord-344093-3bniy5b5	465	85	related	relate	VBN
cord-344093-3bniy5b5	465	86	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	465	87	-	-	HYPH
cord-344093-3bniy5b5	465	88	inducing	induce	VBG
cord-344093-3bniy5b5	465	89	ligand	ligand	NN
cord-344093-3bniy5b5	465	90	(	(	-LRB-
cord-344093-3bniy5b5	465	91	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	465	92	)	)	-RRB-
cord-344093-3bniy5b5	465	93	in	in	IN
cord-344093-3bniy5b5	465	94	viral	viral	JJ
cord-344093-3bniy5b5	465	95	and	and	CC
cord-344093-3bniy5b5	465	96	bacterial	bacterial	JJ
cord-344093-3bniy5b5	465	97	infections	infection	NNS
cord-344093-3bniy5b5	465	98	:	:	:
cord-344093-3bniy5b5	465	99	from	from	IN
cord-344093-3bniy5b5	465	100	pathogenesis	pathogenesis	NN
cord-344093-3bniy5b5	465	101	to	to	IN
cord-344093-3bniy5b5	465	102	pathogen	pathogen	NN
cord-344093-3bniy5b5	465	103	clearance	clearance	NN
cord-344093-3bniy5b5	466	1	In	in	IN
cord-344093-3bniy5b5	466	2	vivo	vivo	NN
cord-344093-3bniy5b5	466	3	induction	induction	NN
cord-344093-3bniy5b5	466	4	of	of	IN
cord-344093-3bniy5b5	466	5	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	466	6	by	by	IN
cord-344093-3bniy5b5	467	1	influenza	influenza	NN
cord-344093-3bniy5b5	467	2	virus	virus	NN
cord-344093-3bniy5b5	467	3	Apoptosis	Apoptosis	NNP
cord-344093-3bniy5b5	467	4	signaling	signal	VBG
cord-344093-3bniy5b5	467	5	in	in	IN
cord-344093-3bniy5b5	467	6	influenza	influenza	NN
cord-344093-3bniy5b5	467	7	virus	virus	NN
cord-344093-3bniy5b5	467	8	propagation	propagation	NN
cord-344093-3bniy5b5	467	9	,	,	,
cord-344093-3bniy5b5	467	10	innate	innate	JJ
cord-344093-3bniy5b5	467	11	host	host	NN
cord-344093-3bniy5b5	467	12	defense	defense	NN
cord-344093-3bniy5b5	467	13	,	,	,
cord-344093-3bniy5b5	467	14	and	and	CC
cord-344093-3bniy5b5	467	15	lung	lung	NN
cord-344093-3bniy5b5	467	16	injury	injury	NN
cord-344093-3bniy5b5	468	1	Influenza	Influenza	NNP
cord-344093-3bniy5b5	468	2	A	a	DT
cord-344093-3bniy5b5	468	3	virus	virus	NN
cord-344093-3bniy5b5	468	4	PB1-F2	PB1-F2	NNP
cord-344093-3bniy5b5	468	5	protein	protein	NN
cord-344093-3bniy5b5	468	6	contributes	contribute	VBZ
cord-344093-3bniy5b5	468	7	to	to	IN
cord-344093-3bniy5b5	468	8	viral	viral	JJ
cord-344093-3bniy5b5	468	9	pathogenesis	pathogenesis	NN
cord-344093-3bniy5b5	468	10	in	in	IN
cord-344093-3bniy5b5	468	11	mice	mouse	NNS
cord-344093-3bniy5b5	469	1	The	the	DT
cord-344093-3bniy5b5	469	2	influenza	influenza	NN
cord-344093-3bniy5b5	469	3	virus	virus	NN
cord-344093-3bniy5b5	469	4	protein	protein	NN
cord-344093-3bniy5b5	469	5	PB1-F2	PB1-F2	NNP
cord-344093-3bniy5b5	469	6	inhibits	inhibit	VBZ
cord-344093-3bniy5b5	469	7	the	the	DT
cord-344093-3bniy5b5	469	8	induction	induction	NN
cord-344093-3bniy5b5	469	9	of	of	IN
cord-344093-3bniy5b5	469	10	type	type	NN
cord-344093-3bniy5b5	470	1	I	-PRON-	PRP
cord-344093-3bniy5b5	470	2	interferon	interferon	VBD
cord-344093-3bniy5b5	470	3	at	at	IN
cord-344093-3bniy5b5	470	4	the	the	DT
cord-344093-3bniy5b5	470	5	level	level	NN
cord-344093-3bniy5b5	470	6	of	of	IN
cord-344093-3bniy5b5	470	7	the	the	DT
cord-344093-3bniy5b5	470	8	MAVS	MAVS	NNP
cord-344093-3bniy5b5	470	9	adaptor	adaptor	NN
cord-344093-3bniy5b5	470	10	protein	protein	NN
cord-344093-3bniy5b5	470	11	Matrix	Matrix	NNP
cord-344093-3bniy5b5	470	12	protein	protein	NN
cord-344093-3bniy5b5	470	13	2	2	CD
cord-344093-3bniy5b5	470	14	of	of	IN
cord-344093-3bniy5b5	470	15	influenza	influenza	NN
cord-344093-3bniy5b5	470	16	A	a	DT
cord-344093-3bniy5b5	470	17	virus	virus	NN
cord-344093-3bniy5b5	471	1	blocks	block	VBZ
cord-344093-3bniy5b5	471	2	autophagosome	autophagosome	JJ
cord-344093-3bniy5b5	471	3	fusion	fusion	NN
cord-344093-3bniy5b5	471	4	with	with	IN
cord-344093-3bniy5b5	471	5	lysosomes	lysosomes	JJ
cord-344093-3bniy5b5	471	6	NF	nf	NN
cord-344093-3bniy5b5	471	7	-	-	HYPH
cord-344093-3bniy5b5	471	8	kappaB	kappaB	NNP
cord-344093-3bniy5b5	471	9	-	-	HYPH
cord-344093-3bniy5b5	471	10	dependent	dependent	JJ
cord-344093-3bniy5b5	471	11	induction	induction	NN
cord-344093-3bniy5b5	471	12	of	of	IN
cord-344093-3bniy5b5	471	13	tumor	tumor	NN
cord-344093-3bniy5b5	471	14	necrosis	necrosis	NN
cord-344093-3bniy5b5	471	15	factor	factor	NN
cord-344093-3bniy5b5	471	16	-	-	HYPH
cord-344093-3bniy5b5	471	17	related	relate	VBN
cord-344093-3bniy5b5	471	18	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	471	19	-	-	HYPH
cord-344093-3bniy5b5	471	20	inducing	induce	VBG
cord-344093-3bniy5b5	471	21	ligand	ligand	NN
cord-344093-3bniy5b5	471	22	(	(	-LRB-
cord-344093-3bniy5b5	471	23	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	471	24	)	)	-RRB-
cord-344093-3bniy5b5	471	25	and	and	CC
cord-344093-3bniy5b5	472	1	Fas	Fas	NNP
cord-344093-3bniy5b5	472	2	/	/	SYM
cord-344093-3bniy5b5	472	3	FasL	FasL	NNP
cord-344093-3bniy5b5	472	4	is	be	VBZ
cord-344093-3bniy5b5	472	5	crucial	crucial	JJ
cord-344093-3bniy5b5	472	6	for	for	IN
cord-344093-3bniy5b5	472	7	efficient	efficient	JJ
cord-344093-3bniy5b5	472	8	influenza	influenza	NN
cord-344093-3bniy5b5	472	9	virus	virus	NN
cord-344093-3bniy5b5	472	10	propagation	propagation	NN
cord-344093-3bniy5b5	472	11	Apoptosis	apoptosis	NN
cord-344093-3bniy5b5	472	12	and	and	CC
cord-344093-3bniy5b5	472	13	pathogenesis	pathogenesis	NN
cord-344093-3bniy5b5	472	14	of	of	IN
cord-344093-3bniy5b5	472	15	avian	avian	JJ
cord-344093-3bniy5b5	472	16	influenza	influenza	NN
cord-344093-3bniy5b5	472	17	A	a	NN
cord-344093-3bniy5b5	472	18	(	(	-LRB-
cord-344093-3bniy5b5	472	19	H5N1	H5N1	NNP
cord-344093-3bniy5b5	472	20	)	)	-RRB-
cord-344093-3bniy5b5	472	21	virus	virus	NN
cord-344093-3bniy5b5	472	22	in	in	IN
cord-344093-3bniy5b5	472	23	humans	human	NNS
cord-344093-3bniy5b5	472	24	Role	Role	NNP
cord-344093-3bniy5b5	472	25	of	of	IN
cord-344093-3bniy5b5	472	26	host	host	NN
cord-344093-3bniy5b5	472	27	cytokine	cytokine	NN
cord-344093-3bniy5b5	472	28	responses	response	NNS
cord-344093-3bniy5b5	472	29	in	in	IN
cord-344093-3bniy5b5	472	30	the	the	DT
cord-344093-3bniy5b5	472	31	pathogenesis	pathogenesis	NN
cord-344093-3bniy5b5	472	32	of	of	IN
cord-344093-3bniy5b5	472	33	avian	avian	JJ
cord-344093-3bniy5b5	472	34	H5N1	H5N1	NNP
cord-344093-3bniy5b5	472	35	influenza	influenza	NN
cord-344093-3bniy5b5	472	36	viruses	virus	NNS
cord-344093-3bniy5b5	472	37	in	in	IN
cord-344093-3bniy5b5	472	38	mice	mouse	NNS
cord-344093-3bniy5b5	472	39	H5N1	H5N1	NNP
cord-344093-3bniy5b5	472	40	and	and	CC
cord-344093-3bniy5b5	472	41	1918	1918	CD
cord-344093-3bniy5b5	472	42	pandemic	pandemic	NN
cord-344093-3bniy5b5	472	43	influenza	influenza	NN
cord-344093-3bniy5b5	472	44	virus	virus	NN
cord-344093-3bniy5b5	472	45	infection	infection	NN
cord-344093-3bniy5b5	472	46	results	result	VBZ
cord-344093-3bniy5b5	472	47	in	in	IN
cord-344093-3bniy5b5	472	48	early	early	JJ
cord-344093-3bniy5b5	472	49	and	and	CC
cord-344093-3bniy5b5	472	50	excessive	excessive	JJ
cord-344093-3bniy5b5	472	51	infiltration	infiltration	NN
cord-344093-3bniy5b5	472	52	of	of	IN
cord-344093-3bniy5b5	472	53	macrophages	macrophage	NNS
cord-344093-3bniy5b5	472	54	and	and	CC
cord-344093-3bniy5b5	472	55	neutrophils	neutrophil	NNS
cord-344093-3bniy5b5	472	56	in	in	IN
cord-344093-3bniy5b5	472	57	the	the	DT
cord-344093-3bniy5b5	472	58	lungs	lung	NNS
cord-344093-3bniy5b5	472	59	of	of	IN
cord-344093-3bniy5b5	472	60	mice	mouse	NNS
cord-344093-3bniy5b5	472	61	Regulation	regulation	NN
cord-344093-3bniy5b5	472	62	of	of	IN
cord-344093-3bniy5b5	472	63	necroptosis	necroptosis	NNP
cord-344093-3bniy5b5	472	64	as	as	IN
cord-344093-3bniy5b5	472	65	a	a	DT
cord-344093-3bniy5b5	472	66	viral	viral	JJ
cord-344093-3bniy5b5	472	67	immune	immune	JJ
cord-344093-3bniy5b5	472	68	antagonistic	antagonistic	JJ
cord-344093-3bniy5b5	472	69	mechanism	mechanism	NN
cord-344093-3bniy5b5	472	70	(	(	-LRB-
cord-344093-3bniy5b5	472	71	INM3P.361	inm3p.361	NN
cord-344093-3bniy5b5	472	72	)	)	-RRB-
cord-344093-3bniy5b5	472	73	Role	role	NN
cord-344093-3bniy5b5	472	74	of	of	IN
cord-344093-3bniy5b5	472	75	tumor	tumor	NN
cord-344093-3bniy5b5	472	76	necrosis	necrosis	NN
cord-344093-3bniy5b5	472	77	factor	factor	NN
cord-344093-3bniy5b5	472	78	-	-	HYPH
cord-344093-3bniy5b5	472	79	related	relate	VBN
cord-344093-3bniy5b5	472	80	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	472	81	-	-	HYPH
cord-344093-3bniy5b5	472	82	inducing	induce	VBG
cord-344093-3bniy5b5	472	83	ligand	ligand	NN
cord-344093-3bniy5b5	472	84	in	in	IN
cord-344093-3bniy5b5	472	85	immune	immune	JJ
cord-344093-3bniy5b5	472	86	response	response	NN
cord-344093-3bniy5b5	472	87	to	to	IN
cord-344093-3bniy5b5	472	88	influenza	influenza	NN
cord-344093-3bniy5b5	472	89	virus	virus	NN
cord-344093-3bniy5b5	472	90	infection	infection	NN
cord-344093-3bniy5b5	472	91	in	in	IN
cord-344093-3bniy5b5	472	92	mice	mouse	NNS
cord-344093-3bniy5b5	473	1	The	the	DT
cord-344093-3bniy5b5	473	2	magnitude	magnitude	NN
cord-344093-3bniy5b5	473	3	of	of	IN
cord-344093-3bniy5b5	473	4	the	the	DT
cord-344093-3bniy5b5	473	5	T	T	NNP
cord-344093-3bniy5b5	473	6	cell	cell	NN
cord-344093-3bniy5b5	473	7	response	response	NN
cord-344093-3bniy5b5	473	8	to	to	IN
cord-344093-3bniy5b5	473	9	a	a	DT
cord-344093-3bniy5b5	473	10	clinically	clinically	RB
cord-344093-3bniy5b5	473	11	significant	significant	JJ
cord-344093-3bniy5b5	473	12	dose	dose	NN
cord-344093-3bniy5b5	473	13	of	of	IN
cord-344093-3bniy5b5	473	14	influenza	influenza	NN
cord-344093-3bniy5b5	473	15	virus	virus	NN
cord-344093-3bniy5b5	473	16	is	be	VBZ
cord-344093-3bniy5b5	473	17	regulated	regulate	VBN
cord-344093-3bniy5b5	473	18	by	by	IN
cord-344093-3bniy5b5	473	19	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	473	20	Virus	Virus	NNP
cord-344093-3bniy5b5	473	21	or	or	CC
cord-344093-3bniy5b5	473	22	TLR	TLR	NNP
cord-344093-3bniy5b5	473	23	agonists	agonist	NNS
cord-344093-3bniy5b5	473	24	induce	induce	VBP
cord-344093-3bniy5b5	473	25	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	473	26	-	-	HYPH
cord-344093-3bniy5b5	473	27	mediated	mediate	VBN
cord-344093-3bniy5b5	473	28	cytotoxic	cytotoxic	JJ
cord-344093-3bniy5b5	473	29	activity	activity	NN
cord-344093-3bniy5b5	473	30	of	of	IN
cord-344093-3bniy5b5	473	31	plasmacytoid	plasmacytoid	NN
cord-344093-3bniy5b5	473	32	dendritic	dendritic	JJ
cord-344093-3bniy5b5	473	33	cells	cell	NNS
cord-344093-3bniy5b5	473	34	Functional	functional	JJ
cord-344093-3bniy5b5	473	35	tumor	tumor	NN
cord-344093-3bniy5b5	473	36	necrosis	necrosis	NN
cord-344093-3bniy5b5	473	37	factor	factor	NN
cord-344093-3bniy5b5	473	38	-	-	HYPH
cord-344093-3bniy5b5	473	39	related	relate	VBN
cord-344093-3bniy5b5	473	40	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	473	41	-	-	HYPH
cord-344093-3bniy5b5	473	42	inducing	induce	VBG
cord-344093-3bniy5b5	473	43	ligand	ligand	NN
cord-344093-3bniy5b5	473	44	production	production	NN
cord-344093-3bniy5b5	473	45	by	by	IN
cord-344093-3bniy5b5	473	46	avian	avian	JJ
cord-344093-3bniy5b5	473	47	influenza	influenza	NN
cord-344093-3bniy5b5	473	48	virus	virus	NN
cord-344093-3bniy5b5	473	49	-	-	HYPH
cord-344093-3bniy5b5	473	50	infected	infect	VBN
cord-344093-3bniy5b5	473	51	macrophages	macrophage	NNS
cord-344093-3bniy5b5	473	52	Respiratory	respiratory	JJ
cord-344093-3bniy5b5	473	53	syncytial	syncytial	JJ
cord-344093-3bniy5b5	473	54	virus	virus	NN
cord-344093-3bniy5b5	473	55	infection	infection	NN
cord-344093-3bniy5b5	473	56	of	of	IN
cord-344093-3bniy5b5	473	57	human	human	JJ
cord-344093-3bniy5b5	473	58	airway	airway	NN
cord-344093-3bniy5b5	473	59	epithelial	epithelial	JJ
cord-344093-3bniy5b5	473	60	cells	cell	NNS
cord-344093-3bniy5b5	473	61	is	be	VBZ
cord-344093-3bniy5b5	473	62	polarized	polarized	JJ
cord-344093-3bniy5b5	473	63	,	,	,
cord-344093-3bniy5b5	473	64	specific	specific	JJ
cord-344093-3bniy5b5	473	65	to	to	IN
cord-344093-3bniy5b5	473	66	ciliated	ciliated	JJ
cord-344093-3bniy5b5	473	67	cells	cell	NNS
cord-344093-3bniy5b5	473	68	,	,	,
cord-344093-3bniy5b5	473	69	and	and	CC
cord-344093-3bniy5b5	473	70	without	without	IN
cord-344093-3bniy5b5	473	71	obvious	obvious	JJ
cord-344093-3bniy5b5	473	72	cytopathology	cytopathology	NN
cord-344093-3bniy5b5	473	73	Respiratory	respiratory	JJ
cord-344093-3bniy5b5	473	74	syncytial	syncytial	JJ
cord-344093-3bniy5b5	473	75	virus	virus	NN
cord-344093-3bniy5b5	473	76	infection	infection	NN
cord-344093-3bniy5b5	473	77	sensitizes	sensitize	VBZ
cord-344093-3bniy5b5	473	78	cells	cell	NNS
cord-344093-3bniy5b5	473	79	to	to	IN
cord-344093-3bniy5b5	473	80	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	473	81	mediated	mediate	VBN
cord-344093-3bniy5b5	473	82	by	by	IN
cord-344093-3bniy5b5	473	83	tumor	tumor	NN
cord-344093-3bniy5b5	473	84	necrosis	necrosis	NN
cord-344093-3bniy5b5	473	85	factor	factor	NN
cord-344093-3bniy5b5	473	86	-	-	HYPH
cord-344093-3bniy5b5	473	87	related	relate	VBN
cord-344093-3bniy5b5	473	88	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	473	89	-	-	HYPH
cord-344093-3bniy5b5	473	90	inducing	induce	VBG
cord-344093-3bniy5b5	473	91	ligand	ligand	NN
cord-344093-3bniy5b5	473	92	Toll	toll	NN
cord-344093-3bniy5b5	473	93	-	-	HYPH
cord-344093-3bniy5b5	473	94	like	like	JJ
cord-344093-3bniy5b5	473	95	receptors	receptor	NNS
cord-344093-3bniy5b5	473	96	,	,	,
cord-344093-3bniy5b5	473	97	chemokine	chemokine	NN
cord-344093-3bniy5b5	473	98	receptors	receptor	NNS
cord-344093-3bniy5b5	473	99	and	and	CC
cord-344093-3bniy5b5	473	100	death	death	NN
cord-344093-3bniy5b5	473	101	receptor	receptor	NN
cord-344093-3bniy5b5	473	102	ligands	ligand	NNS
cord-344093-3bniy5b5	473	103	responses	response	NNS
cord-344093-3bniy5b5	473	104	in	in	IN
cord-344093-3bniy5b5	473	105	SARS	SARS	NNP
cord-344093-3bniy5b5	473	106	coronavirus	coronavirus	NN
cord-344093-3bniy5b5	473	107	infected	infect	VBD
cord-344093-3bniy5b5	473	108	human	human	JJ
cord-344093-3bniy5b5	473	109	monocyte	monocyte	NNP
cord-344093-3bniy5b5	473	110	derived	derive	VBN
cord-344093-3bniy5b5	473	111	dendritic	dendritic	JJ
cord-344093-3bniy5b5	473	112	cells	cell	NNS
cord-344093-3bniy5b5	473	113	Involvement	Involvement	NNP
cord-344093-3bniy5b5	473	114	of	of	IN
cord-344093-3bniy5b5	473	115	FOXO	FOXO	NNP
cord-344093-3bniy5b5	473	116	transcription	transcription	NN
cord-344093-3bniy5b5	473	117	factors	factor	NNS
cord-344093-3bniy5b5	473	118	,	,	,
cord-344093-3bniy5b5	473	119	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	473	120	-	-	HYPH
cord-344093-3bniy5b5	473	121	FasL	FasL	NNP
cord-344093-3bniy5b5	473	122	/	/	SYM
cord-344093-3bniy5b5	473	123	Fas	Fas	NNP
cord-344093-3bniy5b5	473	124	,	,	,
cord-344093-3bniy5b5	473	125	and	and	CC
cord-344093-3bniy5b5	473	126	sirtuin	sirtuin	NNP
cord-344093-3bniy5b5	473	127	proteins	protein	VBZ
cord-344093-3bniy5b5	473	128	family	family	NN
cord-344093-3bniy5b5	473	129	in	in	IN
cord-344093-3bniy5b5	473	130	canine	canine	JJ
cord-344093-3bniy5b5	473	131	coronavirus	coronavirus	NN
cord-344093-3bniy5b5	473	132	type	type	NN
cord-344093-3bniy5b5	473	133	II	ii	NN
cord-344093-3bniy5b5	473	134	-	-	HYPH
cord-344093-3bniy5b5	473	135	induced	induce	VBN
cord-344093-3bniy5b5	473	136	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	473	137	Lung	lung	NN
cord-344093-3bniy5b5	473	138	pathology	pathology	NN
cord-344093-3bniy5b5	473	139	of	of	IN
cord-344093-3bniy5b5	473	140	severe	severe	JJ
cord-344093-3bniy5b5	473	141	acute	acute	JJ
cord-344093-3bniy5b5	473	142	respiratory	respiratory	JJ
cord-344093-3bniy5b5	473	143	syndrome	syndrome	NN
cord-344093-3bniy5b5	474	1	Severe	severe	JJ
cord-344093-3bniy5b5	475	1	acute	acute	JJ
cord-344093-3bniy5b5	475	2	respiratory	respiratory	JJ
cord-344093-3bniy5b5	475	3	syndrome	syndrome	NN
cord-344093-3bniy5b5	475	4	coronavirus	coronavirus	NN
cord-344093-3bniy5b5	475	5	triggers	trigger	VBZ
cord-344093-3bniy5b5	475	6	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	475	7	via	via	IN
cord-344093-3bniy5b5	475	8	protein	protein	NN
cord-344093-3bniy5b5	475	9	kinase	kinase	NN
cord-344093-3bniy5b5	475	10	r	r	NN
cord-344093-3bniy5b5	475	11	but	but	CC
cord-344093-3bniy5b5	475	12	is	be	VBZ
cord-344093-3bniy5b5	475	13	resistant	resistant	JJ
cord-344093-3bniy5b5	475	14	to	to	IN
cord-344093-3bniy5b5	475	15	its	-PRON-	PRP$
cord-344093-3bniy5b5	475	16	antiviral	antiviral	JJ
cord-344093-3bniy5b5	475	17	activity	activity	NN
cord-344093-3bniy5b5	475	18	Delayed	delay	VBN
cord-344093-3bniy5b5	475	19	induction	induction	NN
cord-344093-3bniy5b5	475	20	of	of	IN
cord-344093-3bniy5b5	475	21	proinflammatory	proinflammatory	JJ
cord-344093-3bniy5b5	475	22	cytokines	cytokine	NNS
cord-344093-3bniy5b5	475	23	and	and	CC
cord-344093-3bniy5b5	475	24	suppression	suppression	NN
cord-344093-3bniy5b5	475	25	of	of	IN
cord-344093-3bniy5b5	475	26	innate	innate	JJ
cord-344093-3bniy5b5	475	27	antiviral	antiviral	JJ
cord-344093-3bniy5b5	475	28	response	response	NN
cord-344093-3bniy5b5	475	29	by	by	IN
cord-344093-3bniy5b5	475	30	the	the	DT
cord-344093-3bniy5b5	475	31	novel	novel	JJ
cord-344093-3bniy5b5	475	32	Middle	Middle	NNP
cord-344093-3bniy5b5	475	33	East	East	NNP
cord-344093-3bniy5b5	475	34	respiratory	respiratory	JJ
cord-344093-3bniy5b5	475	35	syndrome	syndrome	NN
cord-344093-3bniy5b5	475	36	coronavirus	coronavirus	NN
cord-344093-3bniy5b5	475	37	:	:	:
cord-344093-3bniy5b5	475	38	implications	implication	NNS
cord-344093-3bniy5b5	475	39	for	for	IN
cord-344093-3bniy5b5	475	40	pathogenesis	pathogenesis	NN
cord-344093-3bniy5b5	475	41	and	and	CC
cord-344093-3bniy5b5	475	42	treatment	treatment	NN
cord-344093-3bniy5b5	475	43	Active	active	JJ
cord-344093-3bniy5b5	475	44	replication	replication	NN
cord-344093-3bniy5b5	475	45	of	of	IN
cord-344093-3bniy5b5	475	46	Middle	Middle	NNP
cord-344093-3bniy5b5	475	47	East	East	NNP
cord-344093-3bniy5b5	475	48	respiratory	respiratory	JJ
cord-344093-3bniy5b5	475	49	syndrome	syndrome	NN
cord-344093-3bniy5b5	475	50	coronavirus	coronavirus	NN
cord-344093-3bniy5b5	475	51	and	and	CC
cord-344093-3bniy5b5	475	52	aberrant	aberrant	JJ
cord-344093-3bniy5b5	475	53	induction	induction	NN
cord-344093-3bniy5b5	475	54	of	of	IN
cord-344093-3bniy5b5	475	55	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	475	56	cytokines	cytokine	NNS
cord-344093-3bniy5b5	475	57	and	and	CC
cord-344093-3bniy5b5	475	58	chemokines	chemokine	NNS
cord-344093-3bniy5b5	475	59	in	in	IN
cord-344093-3bniy5b5	475	60	human	human	JJ
cord-344093-3bniy5b5	475	61	macrophages	macrophage	NNS
cord-344093-3bniy5b5	475	62	:	:	:
cord-344093-3bniy5b5	475	63	implications	implication	NNS
cord-344093-3bniy5b5	475	64	for	for	IN
cord-344093-3bniy5b5	475	65	pathogenesis	pathogenesis	NN
cord-344093-3bniy5b5	475	66	Influenza	influenza	NN
cord-344093-3bniy5b5	475	67	and	and	CC
cord-344093-3bniy5b5	475	68	bacterial	bacterial	JJ
cord-344093-3bniy5b5	475	69	superinfection	superinfection	NN
cord-344093-3bniy5b5	475	70	:	:	:
cord-344093-3bniy5b5	475	71	illuminating	illuminate	VBG
cord-344093-3bniy5b5	475	72	the	the	DT
cord-344093-3bniy5b5	475	73	immunologic	immunologic	JJ
cord-344093-3bniy5b5	475	74	mechanisms	mechanism	NNS
cord-344093-3bniy5b5	475	75	of	of	IN
cord-344093-3bniy5b5	475	76	disease	disease	NN
cord-344093-3bniy5b5	475	77	Autopsy	Autopsy	NNP
cord-344093-3bniy5b5	475	78	series	series	NN
cord-344093-3bniy5b5	475	79	of	of	IN
cord-344093-3bniy5b5	475	80	68	68	CD
cord-344093-3bniy5b5	475	81	cases	case	NNS
cord-344093-3bniy5b5	475	82	dying	die	VBG
cord-344093-3bniy5b5	475	83	before	before	RB
cord-344093-3bniy5b5	475	84	and	and	CC
cord-344093-3bniy5b5	476	1	during	during	IN
cord-344093-3bniy5b5	476	2	the	the	DT
cord-344093-3bniy5b5	476	3	1918	1918	CD
cord-344093-3bniy5b5	476	4	influenza	influenza	NN
cord-344093-3bniy5b5	476	5	pandemic	pandemic	NN
cord-344093-3bniy5b5	476	6	peak	peak	NN
cord-344093-3bniy5b5	476	7	The	the	DT
cord-344093-3bniy5b5	476	8	impact	impact	NN
cord-344093-3bniy5b5	476	9	of	of	IN
cord-344093-3bniy5b5	476	10	bacterial	bacterial	JJ
cord-344093-3bniy5b5	476	11	and	and	CC
cord-344093-3bniy5b5	476	12	viral	viral	JJ
cord-344093-3bniy5b5	476	13	co	co	NN
cord-344093-3bniy5b5	476	14	-	-	NN
cord-344093-3bniy5b5	476	15	infection	infection	NN
cord-344093-3bniy5b5	476	16	in	in	IN
cord-344093-3bniy5b5	476	17	severe	severe	JJ
cord-344093-3bniy5b5	476	18	influenza	influenza	NN
cord-344093-3bniy5b5	476	19	Type	type	NN
cord-344093-3bniy5b5	476	20	I	-PRON-	PRP
cord-344093-3bniy5b5	476	21	interferons	interferon	NNS
cord-344093-3bniy5b5	476	22	in	in	IN
cord-344093-3bniy5b5	476	23	infectious	infectious	JJ
cord-344093-3bniy5b5	476	24	disease	disease	NN
cord-344093-3bniy5b5	476	25	Type	type	NN
cord-344093-3bniy5b5	476	26	I	-PRON-	PRP
cord-344093-3bniy5b5	476	27	IFNs	ifns	VBP
cord-344093-3bniy5b5	476	28	mediate	mediate	VB
cord-344093-3bniy5b5	476	29	development	development	NN
cord-344093-3bniy5b5	476	30	of	of	IN
cord-344093-3bniy5b5	476	31	postinfluenza	postinfluenza	NNP
cord-344093-3bniy5b5	476	32	bacterial	bacterial	JJ
cord-344093-3bniy5b5	476	33	pneumonia	pneumonia	NN
cord-344093-3bniy5b5	476	34	in	in	IN
cord-344093-3bniy5b5	476	35	mice	mouse	NNS
cord-344093-3bniy5b5	476	36	Synergistic	synergistic	JJ
cord-344093-3bniy5b5	476	37	stimulation	stimulation	NN
cord-344093-3bniy5b5	476	38	of	of	IN
cord-344093-3bniy5b5	476	39	type	type	NN
cord-344093-3bniy5b5	477	1	I	-PRON-	PRP
cord-344093-3bniy5b5	477	2	interferons	interferon	NNS
cord-344093-3bniy5b5	477	3	during	during	IN
cord-344093-3bniy5b5	477	4	influenza	influenza	NN
cord-344093-3bniy5b5	477	5	virus	virus	NN
cord-344093-3bniy5b5	477	6	coinfection	coinfection	NN
cord-344093-3bniy5b5	477	7	promotes	promote	VBZ
cord-344093-3bniy5b5	477	8	Streptococcus	Streptococcus	NNP
cord-344093-3bniy5b5	477	9	pneumoniae	pneumoniae	NN
cord-344093-3bniy5b5	477	10	colonization	colonization	NN
cord-344093-3bniy5b5	477	11	in	in	IN
cord-344093-3bniy5b5	477	12	mice	mouse	NNS
cord-344093-3bniy5b5	478	1	Type	type	NN
cord-344093-3bniy5b5	479	1	I	-PRON-	PRP
cord-344093-3bniy5b5	480	1	interferon	interferon	NNP
cord-344093-3bniy5b5	480	2	induction	induction	NN
cord-344093-3bniy5b5	480	3	during	during	IN
cord-344093-3bniy5b5	480	4	influenza	influenza	NN
cord-344093-3bniy5b5	480	5	virus	virus	NN
cord-344093-3bniy5b5	480	6	infection	infection	NN
cord-344093-3bniy5b5	480	7	increases	increase	VBZ
cord-344093-3bniy5b5	480	8	susceptibility	susceptibility	NN
cord-344093-3bniy5b5	480	9	to	to	IN
cord-344093-3bniy5b5	480	10	secondary	secondary	JJ
cord-344093-3bniy5b5	480	11	Streptococcus	streptococcus	NN
cord-344093-3bniy5b5	480	12	pneumoniae	pneumoniae	NN
cord-344093-3bniy5b5	480	13	infection	infection	NN
cord-344093-3bniy5b5	480	14	by	by	IN
cord-344093-3bniy5b5	480	15	negative	negative	JJ
cord-344093-3bniy5b5	480	16	regulation	regulation	NN
cord-344093-3bniy5b5	480	17	of	of	IN
cord-344093-3bniy5b5	480	18	T	t	NN
cord-344093-3bniy5b5	480	19	cells	cell	NNS
cord-344093-3bniy5b5	480	20	Induction	Induction	NNP
cord-344093-3bniy5b5	480	21	of	of	IN
cord-344093-3bniy5b5	480	22	IFN	IFN	NNP
cord-344093-3bniy5b5	480	23	-	-	HYPH
cord-344093-3bniy5b5	480	24	alphabeta	alphabeta	NNP
cord-344093-3bniy5b5	480	25	enables	enable	VBZ
cord-344093-3bniy5b5	480	26	Listeria	Listeria	NNP
cord-344093-3bniy5b5	480	27	monocytogenes	monocytogene	NNS
cord-344093-3bniy5b5	480	28	to	to	TO
cord-344093-3bniy5b5	480	29	suppress	suppress	VB
cord-344093-3bniy5b5	480	30	macrophage	macrophage	NN
cord-344093-3bniy5b5	480	31	activation	activation	NN
cord-344093-3bniy5b5	480	32	by	by	IN
cord-344093-3bniy5b5	480	33	IFN	IFN	NNP
cord-344093-3bniy5b5	480	34	-	-	HYPH
cord-344093-3bniy5b5	480	35	gamma	gamma	NN
cord-344093-3bniy5b5	480	36	Increased	increase	VBN
cord-344093-3bniy5b5	480	37	susceptibility	susceptibility	NN
cord-344093-3bniy5b5	480	38	to	to	IN
cord-344093-3bniy5b5	480	39	bacterial	bacterial	JJ
cord-344093-3bniy5b5	480	40	superinfection	superinfection	NN
cord-344093-3bniy5b5	480	41	as	as	IN
cord-344093-3bniy5b5	480	42	a	a	DT
cord-344093-3bniy5b5	480	43	consequence	consequence	NN
cord-344093-3bniy5b5	480	44	of	of	IN
cord-344093-3bniy5b5	480	45	innate	innate	JJ
cord-344093-3bniy5b5	480	46	antiviral	antiviral	JJ
cord-344093-3bniy5b5	480	47	responses	response	NNS
cord-344093-3bniy5b5	480	48	The	the	DT
cord-344093-3bniy5b5	480	49	methyltransferase	methyltransferase	NN
cord-344093-3bniy5b5	480	50	Setdb2	Setdb2	NNP
cord-344093-3bniy5b5	480	51	mediates	mediate	VBZ
cord-344093-3bniy5b5	480	52	virus	virus	NN
cord-344093-3bniy5b5	480	53	-	-	HYPH
cord-344093-3bniy5b5	480	54	induced	induce	VBN
cord-344093-3bniy5b5	480	55	susceptibility	susceptibility	NN
cord-344093-3bniy5b5	480	56	to	to	IN
cord-344093-3bniy5b5	480	57	bacterial	bacterial	JJ
cord-344093-3bniy5b5	480	58	superinfection	superinfection	NN
cord-344093-3bniy5b5	480	59	Induction	Induction	NNP
cord-344093-3bniy5b5	480	60	of	of	IN
cord-344093-3bniy5b5	480	61	type	type	NN
cord-344093-3bniy5b5	481	1	I	-PRON-	PRP
cord-344093-3bniy5b5	481	2	interferon	interferon	RB
cord-344093-3bniy5b5	481	3	signaling	signal	VBG
cord-344093-3bniy5b5	481	4	determines	determine	VBZ
cord-344093-3bniy5b5	481	5	the	the	DT
cord-344093-3bniy5b5	481	6	relative	relative	JJ
cord-344093-3bniy5b5	481	7	pathogenicity	pathogenicity	NN
cord-344093-3bniy5b5	481	8	of	of	IN
cord-344093-3bniy5b5	481	9	Staphylococcus	Staphylococcus	NNP
cord-344093-3bniy5b5	481	10	aureus	aureus	NN
cord-344093-3bniy5b5	481	11	strains	strain	NNS
cord-344093-3bniy5b5	482	1	Poly	Poly	NNP
cord-344093-3bniy5b5	482	2	I	i	NN
cord-344093-3bniy5b5	482	3	:	:	:
cord-344093-3bniy5b5	482	4	C	C	NNP
cord-344093-3bniy5b5	482	5	enhances	enhance	VBZ
cord-344093-3bniy5b5	482	6	susceptibility	susceptibility	NN
cord-344093-3bniy5b5	482	7	to	to	IN
cord-344093-3bniy5b5	482	8	secondary	secondary	JJ
cord-344093-3bniy5b5	482	9	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	482	10	infections	infection	NNS
cord-344093-3bniy5b5	482	11	by	by	IN
cord-344093-3bniy5b5	482	12	Gram	gram	NN
cord-344093-3bniy5b5	482	13	-	-	HYPH
cord-344093-3bniy5b5	482	14	positive	positive	JJ
cord-344093-3bniy5b5	482	15	bacteria	bacteria	NNS
cord-344093-3bniy5b5	482	16	Differential	differential	NN
cord-344093-3bniy5b5	482	17	type	type	NN
cord-344093-3bniy5b5	483	1	I	-PRON-	PRP
cord-344093-3bniy5b5	483	2	interferon	interferon	RB
cord-344093-3bniy5b5	483	3	signaling	signal	VBG
cord-344093-3bniy5b5	483	4	is	be	VBZ
cord-344093-3bniy5b5	483	5	a	a	DT
cord-344093-3bniy5b5	483	6	master	master	NN
cord-344093-3bniy5b5	483	7	regulator	regulator	NN
cord-344093-3bniy5b5	483	8	of	of	IN
cord-344093-3bniy5b5	483	9	susceptibility	susceptibility	NN
cord-344093-3bniy5b5	483	10	to	to	IN
cord-344093-3bniy5b5	483	11	postinfluenza	postinfluenza	NNP
cord-344093-3bniy5b5	483	12	bacterial	bacterial	JJ
cord-344093-3bniy5b5	483	13	superinfection	superinfection	NN
cord-344093-3bniy5b5	483	14	A	a	DT
cord-344093-3bniy5b5	483	15	mouse	mouse	NN
cord-344093-3bniy5b5	483	16	model	model	NN
cord-344093-3bniy5b5	483	17	of	of	IN
cord-344093-3bniy5b5	483	18	lethal	lethal	JJ
cord-344093-3bniy5b5	483	19	synergism	synergism	NN
cord-344093-3bniy5b5	483	20	between	between	IN
cord-344093-3bniy5b5	483	21	influenza	influenza	NN
cord-344093-3bniy5b5	483	22	virus	virus	NN
cord-344093-3bniy5b5	483	23	and	and	CC
cord-344093-3bniy5b5	483	24	Haemophilus	Haemophilus	NNP
cord-344093-3bniy5b5	483	25	influenzae	influenzae	NN
cord-344093-3bniy5b5	483	26	TNF	tnf	NN
cord-344093-3bniy5b5	483	27	-	-	HYPH
cord-344093-3bniy5b5	483	28	related	relate	VBN
cord-344093-3bniy5b5	483	29	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	483	30	-	-	HYPH
cord-344093-3bniy5b5	483	31	inducing	induce	VBG
cord-344093-3bniy5b5	483	32	ligand	ligand	NN
cord-344093-3bniy5b5	483	33	(	(	-LRB-
cord-344093-3bniy5b5	483	34	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	483	35	)	)	-RRB-
cord-344093-3bniy5b5	483	36	exerts	exert	VBZ
cord-344093-3bniy5b5	483	37	therapeutic	therapeutic	JJ
cord-344093-3bniy5b5	483	38	efficacy	efficacy	NN
cord-344093-3bniy5b5	483	39	for	for	IN
cord-344093-3bniy5b5	483	40	the	the	DT
cord-344093-3bniy5b5	483	41	treatment	treatment	NN
cord-344093-3bniy5b5	483	42	of	of	IN
cord-344093-3bniy5b5	483	43	pneumococcal	pneumococcal	JJ
cord-344093-3bniy5b5	483	44	pneumonia	pneumonia	NN
cord-344093-3bniy5b5	483	45	in	in	IN
cord-344093-3bniy5b5	483	46	mice	mouse	NNS
cord-344093-3bniy5b5	483	47	Tumor	tumor	NN
cord-344093-3bniy5b5	483	48	necrosis	necrosis	NN
cord-344093-3bniy5b5	483	49	factor	factor	NN
cord-344093-3bniy5b5	483	50	-	-	HYPH
cord-344093-3bniy5b5	483	51	related	relate	VBN
cord-344093-3bniy5b5	483	52	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	483	53	-	-	HYPH
cord-344093-3bniy5b5	483	54	inducing	induce	VBG
cord-344093-3bniy5b5	483	55	ligand	ligand	NN
cord-344093-3bniy5b5	484	1	translates	translate	VBZ
cord-344093-3bniy5b5	484	2	neonatal	neonatal	JJ
cord-344093-3bniy5b5	484	3	respiratory	respiratory	JJ
cord-344093-3bniy5b5	484	4	infection	infection	NN
cord-344093-3bniy5b5	484	5	into	into	IN
cord-344093-3bniy5b5	484	6	chronic	chronic	JJ
cord-344093-3bniy5b5	484	7	lung	lung	NN
cord-344093-3bniy5b5	484	8	disease	disease	NN
cord-344093-3bniy5b5	484	9	Critical	critical	JJ
cord-344093-3bniy5b5	484	10	link	link	NN
cord-344093-3bniy5b5	484	11	between	between	IN
cord-344093-3bniy5b5	484	12	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	484	13	and	and	CC
cord-344093-3bniy5b5	484	14	CCL20	CCL20	VBZ
cord-344093-3bniy5b5	484	15	for	for	IN
cord-344093-3bniy5b5	484	16	the	the	DT
cord-344093-3bniy5b5	484	17	activation	activation	NN
cord-344093-3bniy5b5	484	18	of	of	IN
cord-344093-3bniy5b5	484	19	TH2	TH2	NNP
cord-344093-3bniy5b5	484	20	cells	cell	NNS
cord-344093-3bniy5b5	484	21	and	and	CC
cord-344093-3bniy5b5	484	22	the	the	DT
cord-344093-3bniy5b5	484	23	expression	expression	NN
cord-344093-3bniy5b5	484	24	of	of	IN
cord-344093-3bniy5b5	484	25	allergic	allergic	JJ
cord-344093-3bniy5b5	484	26	airway	airway	NN
cord-344093-3bniy5b5	484	27	disease	disease	NN
cord-344093-3bniy5b5	484	28	Viral	viral	JJ
cord-344093-3bniy5b5	484	29	and	and	CC
cord-344093-3bniy5b5	484	30	bacterial	bacterial	JJ
cord-344093-3bniy5b5	484	31	etiologies	etiology	NNS
cord-344093-3bniy5b5	484	32	in	in	IN
cord-344093-3bniy5b5	484	33	acute	acute	JJ
cord-344093-3bniy5b5	484	34	exacerbation	exacerbation	NN
cord-344093-3bniy5b5	484	35	of	of	IN
cord-344093-3bniy5b5	484	36	COPD	COPD	NNP
cord-344093-3bniy5b5	484	37	detected	detect	VBD
cord-344093-3bniy5b5	484	38	using	use	VBG
cord-344093-3bniy5b5	484	39	a	a	DT
cord-344093-3bniy5b5	484	40	multiplex	multiplex	JJ
cord-344093-3bniy5b5	484	41	real	real	JJ
cord-344093-3bniy5b5	484	42	-	-	HYPH
cord-344093-3bniy5b5	484	43	time	time	NN
cord-344093-3bniy5b5	484	44	polymerase	polymerase	NN
cord-344093-3bniy5b5	484	45	chain	chain	NN
cord-344093-3bniy5b5	484	46	reaction	reaction	NN
cord-344093-3bniy5b5	485	1	Impaired	impaired	JJ
cord-344093-3bniy5b5	485	2	antiviral	antiviral	JJ
cord-344093-3bniy5b5	485	3	stress	stress	NN
cord-344093-3bniy5b5	485	4	granule	granule	NN
cord-344093-3bniy5b5	485	5	and	and	CC
cord-344093-3bniy5b5	485	6	IFN	IFN	NNP
cord-344093-3bniy5b5	485	7	-	-	HYPH
cord-344093-3bniy5b5	485	8	β	β	NNP
cord-344093-3bniy5b5	485	9	enhanceosome	enhanceosome	NN
cord-344093-3bniy5b5	485	10	formation	formation	NN
cord-344093-3bniy5b5	485	11	enhances	enhance	VBZ
cord-344093-3bniy5b5	485	12	susceptibility	susceptibility	NN
cord-344093-3bniy5b5	485	13	to	to	IN
cord-344093-3bniy5b5	485	14	influenza	influenza	NN
cord-344093-3bniy5b5	485	15	infection	infection	NN
cord-344093-3bniy5b5	485	16	in	in	IN
cord-344093-3bniy5b5	485	17	chronic	chronic	JJ
cord-344093-3bniy5b5	485	18	obstructive	obstructive	JJ
cord-344093-3bniy5b5	485	19	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	485	20	disease	disease	NN
cord-344093-3bniy5b5	485	21	epithelium	epithelium	NN
cord-344093-3bniy5b5	485	22	Alveolar	alveolar	NN
cord-344093-3bniy5b5	485	23	epithelial	epithelial	JJ
cord-344093-3bniy5b5	485	24	and	and	CC
cord-344093-3bniy5b5	485	25	endothelial	endothelial	JJ
cord-344093-3bniy5b5	485	26	cell	cell	NN
cord-344093-3bniy5b5	485	27	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	485	28	in	in	IN
cord-344093-3bniy5b5	485	29	emphysema	emphysema	NN
cord-344093-3bniy5b5	485	30	:	:	:
cord-344093-3bniy5b5	486	1	what	what	WP
cord-344093-3bniy5b5	486	2	we	-PRON-	PRP
cord-344093-3bniy5b5	486	3	know	know	VBP
cord-344093-3bniy5b5	486	4	and	and	CC
cord-344093-3bniy5b5	486	5	what	what	WP
cord-344093-3bniy5b5	486	6	we	-PRON-	PRP
cord-344093-3bniy5b5	486	7	need	need	VBP
cord-344093-3bniy5b5	486	8	to	to	TO
cord-344093-3bniy5b5	486	9	know	know	VB
cord-344093-3bniy5b5	486	10	A	a	DT
cord-344093-3bniy5b5	486	11	pathogenic	pathogenic	JJ
cord-344093-3bniy5b5	486	12	role	role	NN
cord-344093-3bniy5b5	486	13	for	for	IN
cord-344093-3bniy5b5	486	14	tumor	tumor	NN
cord-344093-3bniy5b5	486	15	necrosis	necrosis	NN
cord-344093-3bniy5b5	486	16	factor	factor	NN
cord-344093-3bniy5b5	486	17	-	-	HYPH
cord-344093-3bniy5b5	486	18	related	relate	VBN
cord-344093-3bniy5b5	486	19	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	486	20	-	-	HYPH
cord-344093-3bniy5b5	486	21	inducing	induce	VBG
cord-344093-3bniy5b5	486	22	ligand	ligand	NN
cord-344093-3bniy5b5	486	23	in	in	IN
cord-344093-3bniy5b5	486	24	chronic	chronic	JJ
cord-344093-3bniy5b5	486	25	obstructive	obstructive	JJ
cord-344093-3bniy5b5	486	26	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	486	27	disease	disease	NN
cord-344093-3bniy5b5	487	1	Increased	increase	VBN
cord-344093-3bniy5b5	487	2	serum	serum	NN
cord-344093-3bniy5b5	487	3	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	487	4	and	and	CC
cord-344093-3bniy5b5	487	5	DR5	DR5	NNP
cord-344093-3bniy5b5	487	6	levels	level	NNS
cord-344093-3bniy5b5	487	7	correlated	correlate	VBN
cord-344093-3bniy5b5	487	8	with	with	IN
cord-344093-3bniy5b5	487	9	lung	lung	NN
cord-344093-3bniy5b5	487	10	function	function	NN
cord-344093-3bniy5b5	487	11	and	and	CC
cord-344093-3bniy5b5	487	12	inflammation	inflammation	NN
cord-344093-3bniy5b5	487	13	in	in	IN
cord-344093-3bniy5b5	487	14	stable	stable	JJ
cord-344093-3bniy5b5	487	15	COPD	COPD	NNP
cord-344093-3bniy5b5	487	16	patients	patient	NNS
cord-344093-3bniy5b5	488	1	Viral	viral	JJ
cord-344093-3bniy5b5	488	2	infection	infection	NN
cord-344093-3bniy5b5	488	3	and	and	CC
cord-344093-3bniy5b5	488	4	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	488	5	hypertension	hypertension	NN
cord-344093-3bniy5b5	488	6	:	:	:
cord-344093-3bniy5b5	488	7	is	be	VBZ
cord-344093-3bniy5b5	488	8	there	there	EX
cord-344093-3bniy5b5	488	9	an	an	DT
cord-344093-3bniy5b5	488	10	association	association	NN
cord-344093-3bniy5b5	488	11	?	?	.
cord-344093-3bniy5b5	489	1	Irreversible	irreversible	JJ
cord-344093-3bniy5b5	489	2	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	489	3	hypertension	hypertension	NN
cord-344093-3bniy5b5	489	4	associated	associate	VBN
cord-344093-3bniy5b5	489	5	with	with	IN
cord-344093-3bniy5b5	489	6	the	the	DT
cord-344093-3bniy5b5	489	7	use	use	NN
cord-344093-3bniy5b5	489	8	of	of	IN
cord-344093-3bniy5b5	489	9	interferon	interferon	NN
cord-344093-3bniy5b5	489	10	alpha	alpha	NN
cord-344093-3bniy5b5	489	11	for	for	IN
cord-344093-3bniy5b5	489	12	chronic	chronic	JJ
cord-344093-3bniy5b5	489	13	hepatitis	hepatitis	NN
cord-344093-3bniy5b5	489	14	C	C	NNP
cord-344093-3bniy5b5	489	15	Interferoninduced	Interferoninduced	NNP
cord-344093-3bniy5b5	489	16	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	489	17	hypertension	hypertension	NN
cord-344093-3bniy5b5	490	1	The	the	DT
cord-344093-3bniy5b5	490	2	role	role	NN
cord-344093-3bniy5b5	490	3	of	of	IN
cord-344093-3bniy5b5	490	4	the	the	DT
cord-344093-3bniy5b5	490	5	osteoprotegerin	osteoprotegerin	NN
cord-344093-3bniy5b5	490	6	/	/	SYM
cord-344093-3bniy5b5	490	7	tumor	tumor	NN
cord-344093-3bniy5b5	490	8	necrosis	necrosis	NN
cord-344093-3bniy5b5	490	9	factor	factor	NN
cord-344093-3bniy5b5	490	10	related	relate	VBN
cord-344093-3bniy5b5	490	11	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	490	12	-	-	HYPH
cord-344093-3bniy5b5	490	13	inducing	induce	VBG
cord-344093-3bniy5b5	490	14	ligand	ligand	NN
cord-344093-3bniy5b5	490	15	axis	axis	NN
cord-344093-3bniy5b5	490	16	in	in	IN
cord-344093-3bniy5b5	490	17	the	the	DT
cord-344093-3bniy5b5	490	18	pathogenesis	pathogenesis	NN
cord-344093-3bniy5b5	490	19	of	of	IN
cord-344093-3bniy5b5	490	20	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	490	21	arterial	arterial	JJ
cord-344093-3bniy5b5	490	22	hypertension	hypertension	NN
cord-344093-3bniy5b5	490	23	Inhibition	inhibition	NN
cord-344093-3bniy5b5	490	24	of	of	IN
cord-344093-3bniy5b5	490	25	tumor	tumor	NN
cord-344093-3bniy5b5	490	26	necrosis	necrosis	NN
cord-344093-3bniy5b5	490	27	factor	factor	NN
cord-344093-3bniy5b5	490	28	-	-	HYPH
cord-344093-3bniy5b5	490	29	related	relate	VBN
cord-344093-3bniy5b5	490	30	apoptosis	apoptosis	NN
cord-344093-3bniy5b5	490	31	-	-	HYPH
cord-344093-3bniy5b5	490	32	inducing	induce	VBG
cord-344093-3bniy5b5	490	33	ligand	ligand	NN
cord-344093-3bniy5b5	490	34	(	(	-LRB-
cord-344093-3bniy5b5	490	35	TRAIL	TRAIL	NNP
cord-344093-3bniy5b5	490	36	)	)	-RRB-
cord-344093-3bniy5b5	490	37	reverses	reverse	VBZ
cord-344093-3bniy5b5	490	38	experimental	experimental	JJ
cord-344093-3bniy5b5	490	39	pulmonary	pulmonary	JJ
cord-344093-3bniy5b5	490	40	hypertension	hypertension	NN
cord-344093-3bniy5b5	490	41	Luks	Luks	NNP
cord-344093-3bniy5b5	490	42	AM	AM	NNP
cord-344093-3bniy5b5	490	43	.	.	.
cord-344093-3bniy5b5	491	1	Ventilatory	ventilatory	JJ
cord-344093-3bniy5b5	491	2	strategies	strategy	NNS
cord-344093-3bniy5b5	491	3	and	and	CC
cord-344093-3bniy5b5	491	4	supportive	supportive	JJ
cord-344093-3bniy5b5	491	5	care	care	NN
cord-344093-3bniy5b5	491	6	in	in	IN
cord-344093-3bniy5b5	491	7	acute	acute	JJ
cord-344093-3bniy5b5	491	8	respiratory	respiratory	JJ
cord-344093-3bniy5b5	491	9	distress	distress	NN
cord-344093-3bniy5b5	491	10	syndrome	syndrome	NN
cord-344093-3bniy5b5	491	11	IFNλ	IFNλ	NNS
cord-344093-3bniy5b5	491	12	is	be	VBZ
cord-344093-3bniy5b5	491	13	a	a	DT
cord-344093-3bniy5b5	491	14	potent	potent	JJ
cord-344093-3bniy5b5	491	15	anti	anti	JJ
cord-344093-3bniy5b5	491	16	-	-	JJ
cord-344093-3bniy5b5	491	17	influenza	influenza	JJ
cord-344093-3bniy5b5	491	18	therapeutic	therapeutic	JJ
cord-344093-3bniy5b5	491	19	without	without	IN
cord-344093-3bniy5b5	491	20	the	the	DT
cord-344093-3bniy5b5	491	21	inflammatory	inflammatory	JJ
cord-344093-3bniy5b5	491	22	side	side	NN
cord-344093-3bniy5b5	491	23	effects	effect	NNS
cord-344093-3bniy5b5	491	24	of	of	IN
cord-344093-3bniy5b5	491	25	IFNα	IFNα	NNS
cord-344093-3bniy5b5	491	26	treatment	treatment	NN
cord-344093-3bniy5b5	492	1	The	the	DT
cord-344093-3bniy5b5	492	2	authors	author	NNS
cord-344093-3bniy5b5	492	3	declare	declare	VBP
cord-344093-3bniy5b5	492	4	that	that	IN
cord-344093-3bniy5b5	492	5	the	the	DT
cord-344093-3bniy5b5	492	6	research	research	NN
cord-344093-3bniy5b5	492	7	was	be	VBD
cord-344093-3bniy5b5	492	8	conducted	conduct	VBN
cord-344093-3bniy5b5	492	9	in	in	IN
cord-344093-3bniy5b5	492	10	the	the	DT
cord-344093-3bniy5b5	492	11	absence	absence	NN
cord-344093-3bniy5b5	492	12	of	of	IN
cord-344093-3bniy5b5	492	13	any	any	DT
cord-344093-3bniy5b5	492	14	commercial	commercial	JJ
cord-344093-3bniy5b5	492	15	or	or	CC
cord-344093-3bniy5b5	492	16	financial	financial	JJ
cord-344093-3bniy5b5	492	17	relationships	relationship	NNS
cord-344093-3bniy5b5	492	18	that	that	WDT
cord-344093-3bniy5b5	492	19	could	could	MD
cord-344093-3bniy5b5	492	20	be	be	VB
cord-344093-3bniy5b5	492	21	construed	construe	VBN
cord-344093-3bniy5b5	492	22	as	as	IN
cord-344093-3bniy5b5	492	23	a	a	DT
cord-344093-3bniy5b5	492	24	potential	potential	JJ
cord-344093-3bniy5b5	492	25	conflict	conflict	NN
cord-344093-3bniy5b5	492	26	of	of	IN
cord-344093-3bniy5b5	492	27	interest	interest	NN
cord-344093-3bniy5b5	492	28	.	.	.
cord-344093-3bniy5b5	493	1	is	be	VBZ
cord-344093-3bniy5b5	493	2	cited	cite	VBN
cord-344093-3bniy5b5	493	3	,	,	,
cord-344093-3bniy5b5	493	4	in	in	IN
cord-344093-3bniy5b5	493	5	accordance	accordance	NN
cord-344093-3bniy5b5	493	6	with	with	IN
cord-344093-3bniy5b5	493	7	accepted	accepted	JJ
cord-344093-3bniy5b5	493	8	academic	academic	JJ
cord-344093-3bniy5b5	493	9	practice	practice	NN
cord-344093-3bniy5b5	493	10	.	.	.
cord-344093-3bniy5b5	494	1	No	no	DT
cord-344093-3bniy5b5	494	2	use	use	NN
cord-344093-3bniy5b5	494	3	,	,	,
cord-344093-3bniy5b5	494	4	distribution	distribution	NN
cord-344093-3bniy5b5	494	5	or	or	CC
cord-344093-3bniy5b5	494	6	reproduction	reproduction	NN
cord-344093-3bniy5b5	494	7	is	be	VBZ
cord-344093-3bniy5b5	494	8	permitted	permit	VBN
cord-344093-3bniy5b5	494	9	which	which	WDT
cord-344093-3bniy5b5	494	10	does	do	VBZ
cord-344093-3bniy5b5	494	11	not	not	RB
cord-344093-3bniy5b5	494	12	comply	comply	VB
cord-344093-3bniy5b5	494	13	with	with	IN
cord-344093-3bniy5b5	494	14	these	these	DT
cord-344093-3bniy5b5	494	15	terms	term	NNS
cord-344093-3bniy5b5	494	16	.	.	.