id sid tid token lemma pos cord-339328-wizu3arz 1 1 key key JJ cord-339328-wizu3arz 2 1 : : : cord-339328-wizu3arz 2 2 cord-339328-wizu3arz cord-339328-wizu3arz NNS cord-339328-wizu3arz 2 3 authors author NNS cord-339328-wizu3arz 2 4 : : : cord-339328-wizu3arz 2 5 Jain Jain NNP cord-339328-wizu3arz 2 6 , , , cord-339328-wizu3arz 2 7 Sanjay Sanjay NNP cord-339328-wizu3arz 2 8 K. K. NNP cord-339328-wizu3arz 2 9 title title NN cord-339328-wizu3arz 2 10 : : : cord-339328-wizu3arz 3 1 The the DT cord-339328-wizu3arz 3 2 Promise Promise NNP cord-339328-wizu3arz 3 3 of of IN cord-339328-wizu3arz 3 4 Molecular Molecular NNP cord-339328-wizu3arz 3 5 Imaging Imaging NNP cord-339328-wizu3arz 3 6 in in IN cord-339328-wizu3arz 3 7 the the DT cord-339328-wizu3arz 3 8 Study Study NNP cord-339328-wizu3arz 3 9 and and CC cord-339328-wizu3arz 3 10 Treatment Treatment NNP cord-339328-wizu3arz 3 11 of of IN cord-339328-wizu3arz 3 12 Infectious Infectious NNP cord-339328-wizu3arz 3 13 Diseases Diseases NNPS cord-339328-wizu3arz 3 14 date date NN cord-339328-wizu3arz 3 15 : : : cord-339328-wizu3arz 3 16 2017 2017 CD cord-339328-wizu3arz 3 17 - - HYPH cord-339328-wizu3arz 3 18 02 02 CD cord-339328-wizu3arz 3 19 - - HYPH cord-339328-wizu3arz 3 20 02 02 CD cord-339328-wizu3arz 3 21 journal journal NN cord-339328-wizu3arz 3 22 : : : cord-339328-wizu3arz 3 23 Mol Mol NNP cord-339328-wizu3arz 3 24 Imaging Imaging NNP cord-339328-wizu3arz 3 25 Biol Biol NNP cord-339328-wizu3arz 3 26 DOI DOI NNP cord-339328-wizu3arz 3 27 : : : cord-339328-wizu3arz 3 28 10.1007 10.1007 CD cord-339328-wizu3arz 3 29 / / SYM cord-339328-wizu3arz 3 30 s11307 s11307 NNP cord-339328-wizu3arz 3 31 - - HYPH cord-339328-wizu3arz 3 32 017 017 CD cord-339328-wizu3arz 3 33 - - HYPH cord-339328-wizu3arz 3 34 1055 1055 CD cord-339328-wizu3arz 3 35 - - SYM cord-339328-wizu3arz 3 36 0 0 CD cord-339328-wizu3arz 3 37 sha sha NN cord-339328-wizu3arz 3 38 : : : cord-339328-wizu3arz 3 39 6540e9f3424564b0c1516b930d4f95b10d9f504e 6540e9f3424564b0c1516b930d4f95b10d9f504e CD cord-339328-wizu3arz 3 40 doc_id doc_id CD cord-339328-wizu3arz 3 41 : : : cord-339328-wizu3arz 3 42 339328 339328 CD cord-339328-wizu3arz 3 43 cord_uid cord_uid NNS cord-339328-wizu3arz 3 44 : : : cord-339328-wizu3arz 3 45 wizu3arz wizu3arz XX cord-339328-wizu3arz 4 1 Infectious infectious JJ cord-339328-wizu3arz 4 2 diseases disease NNS cord-339328-wizu3arz 4 3 are be VBP cord-339328-wizu3arz 4 4 a a DT cord-339328-wizu3arz 4 5 major major JJ cord-339328-wizu3arz 4 6 threat threat NN cord-339328-wizu3arz 4 7 to to IN cord-339328-wizu3arz 4 8 humanity humanity NN cord-339328-wizu3arz 4 9 , , , cord-339328-wizu3arz 4 10 and and CC cord-339328-wizu3arz 4 11 it -PRON- PRP cord-339328-wizu3arz 4 12 is be VBZ cord-339328-wizu3arz 4 13 imperative imperative JJ cord-339328-wizu3arz 4 14 that that IN cord-339328-wizu3arz 4 15 we -PRON- PRP cord-339328-wizu3arz 4 16 develop develop VBP cord-339328-wizu3arz 4 17 imaging imaging NN cord-339328-wizu3arz 4 18 tools tool NNS cord-339328-wizu3arz 4 19 that that WDT cord-339328-wizu3arz 4 20 aid aid NN cord-339328-wizu3arz 4 21 in in IN cord-339328-wizu3arz 4 22 their -PRON- PRP$ cord-339328-wizu3arz 4 23 study study NN cord-339328-wizu3arz 4 24 , , , cord-339328-wizu3arz 4 25 facilitate facilitate VB cord-339328-wizu3arz 4 26 diagnosis diagnosis NN cord-339328-wizu3arz 4 27 , , , cord-339328-wizu3arz 4 28 and and CC cord-339328-wizu3arz 4 29 guide guide NN cord-339328-wizu3arz 4 30 treatment treatment NN cord-339328-wizu3arz 4 31 . . . cord-339328-wizu3arz 5 1 The the DT cord-339328-wizu3arz 5 2 alarming alarming JJ cord-339328-wizu3arz 5 3 rise rise NN cord-339328-wizu3arz 5 4 of of IN cord-339328-wizu3arz 5 5 highly highly RB cord-339328-wizu3arz 5 6 virulent virulent JJ cord-339328-wizu3arz 5 7 and and CC cord-339328-wizu3arz 5 8 multi multi JJ cord-339328-wizu3arz 5 9 - - JJ cord-339328-wizu3arz 5 10 drug drug JJ cord-339328-wizu3arz 5 11 - - HYPH cord-339328-wizu3arz 5 12 resistant resistant JJ cord-339328-wizu3arz 5 13 pathogens pathogen NNS cord-339328-wizu3arz 5 14 , , , cord-339328-wizu3arz 5 15 their -PRON- PRP$ cord-339328-wizu3arz 5 16 rapid rapid JJ cord-339328-wizu3arz 5 17 spread spread NN cord-339328-wizu3arz 5 18 leading lead VBG cord-339328-wizu3arz 5 19 to to IN cord-339328-wizu3arz 5 20 frequent frequent JJ cord-339328-wizu3arz 5 21 global global JJ cord-339328-wizu3arz 5 22 pandemics pandemic NNS cord-339328-wizu3arz 5 23 , , , cord-339328-wizu3arz 5 24 fears fear NNS cord-339328-wizu3arz 5 25 of of IN cord-339328-wizu3arz 5 26 bioterrorism bioterrorism NN cord-339328-wizu3arz 5 27 , , , cord-339328-wizu3arz 5 28 and and CC cord-339328-wizu3arz 5 29 continued continue VBN cord-339328-wizu3arz 5 30 life life NN cord-339328-wizu3arz 5 31 - - HYPH cord-339328-wizu3arz 5 32 threatening threaten VBG cord-339328-wizu3arz 5 33 nosocomial nosocomial JJ cord-339328-wizu3arz 5 34 infections infection NNS cord-339328-wizu3arz 5 35 in in IN cord-339328-wizu3arz 5 36 hospitals hospital NNS cord-339328-wizu3arz 5 37 remain remain VBP cord-339328-wizu3arz 5 38 as as IN cord-339328-wizu3arz 5 39 major major JJ cord-339328-wizu3arz 5 40 challenges challenge NNS cord-339328-wizu3arz 5 41 to to IN cord-339328-wizu3arz 5 42 health health NN cord-339328-wizu3arz 5 43 care care NN cord-339328-wizu3arz 5 44 in in IN cord-339328-wizu3arz 5 45 the the DT cord-339328-wizu3arz 5 46 USA USA NNP cord-339328-wizu3arz 5 47 and and CC cord-339328-wizu3arz 5 48 worldwide worldwide RB cord-339328-wizu3arz 5 49 . . . cord-339328-wizu3arz 6 1 Early early JJ cord-339328-wizu3arz 6 2 diagnosis diagnosis NN cord-339328-wizu3arz 6 3 and and CC cord-339328-wizu3arz 6 4 rapid rapid JJ cord-339328-wizu3arz 6 5 monitoring monitoring NN cord-339328-wizu3arz 6 6 are be VBP cord-339328-wizu3arz 6 7 essential essential JJ cord-339328-wizu3arz 6 8 for for IN cord-339328-wizu3arz 6 9 appropriate appropriate JJ cord-339328-wizu3arz 6 10 management management NN cord-339328-wizu3arz 6 11 and and CC cord-339328-wizu3arz 6 12 control control NN cord-339328-wizu3arz 6 13 of of IN cord-339328-wizu3arz 6 14 infections infection NNS cord-339328-wizu3arz 6 15 . . . cord-339328-wizu3arz 7 1 Tomographic tomographic JJ cord-339328-wizu3arz 7 2 molecular molecular JJ cord-339328-wizu3arz 7 3 imaging imaging NN cord-339328-wizu3arz 7 4 enables enable VBZ cord-339328-wizu3arz 7 5 rapid rapid JJ cord-339328-wizu3arz 7 6 , , , cord-339328-wizu3arz 7 7 noninvasive noninvasive JJ cord-339328-wizu3arz 7 8 visualization visualization NN cord-339328-wizu3arz 7 9 , , , cord-339328-wizu3arz 7 10 localization localization NN cord-339328-wizu3arz 7 11 , , , cord-339328-wizu3arz 7 12 and and CC cord-339328-wizu3arz 7 13 monitoring monitoring NN cord-339328-wizu3arz 7 14 of of IN cord-339328-wizu3arz 7 15 molecular molecular JJ cord-339328-wizu3arz 7 16 processes process NNS cord-339328-wizu3arz 7 17 deep deep RB cord-339328-wizu3arz 7 18 within within IN cord-339328-wizu3arz 7 19 the the DT cord-339328-wizu3arz 7 20 body body NN cord-339328-wizu3arz 7 21 and and CC cord-339328-wizu3arz 7 22 offers offer VBZ cord-339328-wizu3arz 7 23 several several JJ cord-339328-wizu3arz 7 24 advantages advantage NNS cord-339328-wizu3arz 7 25 over over IN cord-339328-wizu3arz 7 26 traditional traditional JJ cord-339328-wizu3arz 7 27 tools tool NNS cord-339328-wizu3arz 7 28 used use VBN cord-339328-wizu3arz 7 29 for for IN cord-339328-wizu3arz 7 30 the the DT cord-339328-wizu3arz 7 31 study study NN cord-339328-wizu3arz 7 32 of of IN cord-339328-wizu3arz 7 33 infectious infectious JJ cord-339328-wizu3arz 7 34 diseases disease NNS cord-339328-wizu3arz 7 35 . . . cord-339328-wizu3arz 8 1 Noninvasive noninvasive JJ cord-339328-wizu3arz 8 2 , , , cord-339328-wizu3arz 8 3 longitudinal longitudinal JJ cord-339328-wizu3arz 8 4 assessments assessment NNS cord-339328-wizu3arz 8 5 could could MD cord-339328-wizu3arz 8 6 streamline streamline VB cord-339328-wizu3arz 8 7 animal animal NN cord-339328-wizu3arz 8 8 studies study NNS cord-339328-wizu3arz 8 9 , , , cord-339328-wizu3arz 8 10 allow allow VB cord-339328-wizu3arz 8 11 unique unique JJ cord-339328-wizu3arz 8 12 insights insight NNS cord-339328-wizu3arz 8 13 into into IN cord-339328-wizu3arz 8 14 disease disease NN cord-339328-wizu3arz 8 15 pathogenesis pathogenesis NN cord-339328-wizu3arz 8 16 , , , cord-339328-wizu3arz 8 17 and and CC cord-339328-wizu3arz 8 18 expedite expedite VB cord-339328-wizu3arz 8 19 clinical clinical JJ cord-339328-wizu3arz 8 20 translation translation NN cord-339328-wizu3arz 8 21 of of IN cord-339328-wizu3arz 8 22 new new JJ cord-339328-wizu3arz 8 23 therapeutics therapeutic NNS cord-339328-wizu3arz 8 24 . . . cord-339328-wizu3arz 9 1 Since since IN cord-339328-wizu3arz 9 2 molecular molecular JJ cord-339328-wizu3arz 9 3 imaging imaging NN cord-339328-wizu3arz 9 4 is be VBZ cord-339328-wizu3arz 9 5 already already RB cord-339328-wizu3arz 9 6 in in IN cord-339328-wizu3arz 9 7 common common JJ cord-339328-wizu3arz 9 8 use use NN cord-339328-wizu3arz 9 9 in in IN cord-339328-wizu3arz 9 10 the the DT cord-339328-wizu3arz 9 11 clinic clinic NN cord-339328-wizu3arz 9 12 , , , cord-339328-wizu3arz 9 13 it -PRON- PRP cord-339328-wizu3arz 9 14 could could MD cord-339328-wizu3arz 9 15 also also RB cord-339328-wizu3arz 9 16 become become VB cord-339328-wizu3arz 9 17 a a DT cord-339328-wizu3arz 9 18 valuable valuable JJ cord-339328-wizu3arz 9 19 tool tool NN cord-339328-wizu3arz 9 20 for for IN cord-339328-wizu3arz 9 21 clinical clinical JJ cord-339328-wizu3arz 9 22 studies study NNS cord-339328-wizu3arz 9 23 , , , cord-339328-wizu3arz 9 24 for for IN cord-339328-wizu3arz 9 25 patient patient JJ cord-339328-wizu3arz 9 26 care care NN cord-339328-wizu3arz 9 27 , , , cord-339328-wizu3arz 9 28 for for IN cord-339328-wizu3arz 9 29 public public JJ cord-339328-wizu3arz 9 30 health health NN cord-339328-wizu3arz 9 31 , , , cord-339328-wizu3arz 9 32 and and CC cord-339328-wizu3arz 9 33 for for IN cord-339328-wizu3arz 9 34 enabling enable VBG cord-339328-wizu3arz 9 35 precision precision NN cord-339328-wizu3arz 9 36 medicine medicine NN cord-339328-wizu3arz 9 37 for for IN cord-339328-wizu3arz 9 38 infectious infectious JJ cord-339328-wizu3arz 9 39 diseases disease NNS cord-339328-wizu3arz 9 40 . . . cord-339328-wizu3arz 10 1 Humans human NNS cord-339328-wizu3arz 10 2 in in IN cord-339328-wizu3arz 10 3 the the DT cord-339328-wizu3arz 10 4 modern modern JJ cord-339328-wizu3arz 10 5 era era NN cord-339328-wizu3arz 10 6 are be VBP cord-339328-wizu3arz 10 7 increasingly increasingly RB cord-339328-wizu3arz 10 8 prone prone JJ cord-339328-wizu3arz 10 9 to to IN cord-339328-wizu3arz 10 10 virulent virulent JJ cord-339328-wizu3arz 10 11 infections infection NNS cord-339328-wizu3arz 10 12 . . . cord-339328-wizu3arz 11 1 Selection selection NN cord-339328-wizu3arz 11 2 and and CC cord-339328-wizu3arz 11 3 dissemination dissemination NN cord-339328-wizu3arz 11 4 of of IN cord-339328-wizu3arz 11 5 Bsuper Bsuper NNP cord-339328-wizu3arz 11 6 bugs^by bugs^by DT cord-339328-wizu3arz 11 7 overuse overuse NN cord-339328-wizu3arz 11 8 ( ( -LRB- cord-339328-wizu3arz 11 9 misuse misuse NN cord-339328-wizu3arz 11 10 ) ) -RRB- cord-339328-wizu3arz 11 11 of of IN cord-339328-wizu3arz 11 12 antimicrobials antimicrobial NNS cord-339328-wizu3arz 11 13 , , , cord-339328-wizu3arz 11 14 global global JJ cord-339328-wizu3arz 11 15 travel travel NN cord-339328-wizu3arz 11 16 and and CC cord-339328-wizu3arz 11 17 the the DT cord-339328-wizu3arz 11 18 rapid rapid JJ cord-339328-wizu3arz 11 19 spread spread NN cord-339328-wizu3arz 11 20 of of IN cord-339328-wizu3arz 11 21 infections infection NNS cord-339328-wizu3arz 11 22 , , , cord-339328-wizu3arz 11 23 and and CC cord-339328-wizu3arz 11 24 the the DT cord-339328-wizu3arz 11 25 increasing increase VBG cord-339328-wizu3arz 11 26 use use NN cord-339328-wizu3arz 11 27 of of IN cord-339328-wizu3arz 11 28 medical medical JJ cord-339328-wizu3arz 11 29 procedures procedure NNS cord-339328-wizu3arz 11 30 - - : cord-339328-wizu3arz 11 31 implants implant NNS cord-339328-wizu3arz 11 32 , , , cord-339328-wizu3arz 11 33 catheters catheter NNS cord-339328-wizu3arz 11 34 , , , cord-339328-wizu3arz 11 35 immunosuppressive immunosuppressive JJ cord-339328-wizu3arz 11 36 / / SYM cord-339328-wizu3arz 11 37 cancer cancer NN cord-339328-wizu3arz 11 38 therapies therapy NNS cord-339328-wizu3arz 11 39 - - : cord-339328-wizu3arz 11 40 are be VBP cord-339328-wizu3arz 11 41 leading lead VBG cord-339328-wizu3arz 11 42 to to IN cord-339328-wizu3arz 11 43 life life NN cord-339328-wizu3arz 11 44 - - HYPH cord-339328-wizu3arz 11 45 threatening threaten VBG cord-339328-wizu3arz 11 46 infections infection NNS cord-339328-wizu3arz 11 47 that that WDT cord-339328-wizu3arz 11 48 are be VBP cord-339328-wizu3arz 11 49 a a DT cord-339328-wizu3arz 11 50 growing grow VBG cord-339328-wizu3arz 11 51 threat threat NN cord-339328-wizu3arz 11 52 to to IN cord-339328-wizu3arz 11 53 humanity humanity NN cord-339328-wizu3arz 11 54 [ [ -LRB- cord-339328-wizu3arz 11 55 1 1 CD cord-339328-wizu3arz 11 56 ] ] -RRB- cord-339328-wizu3arz 11 57 [ [ -LRB- cord-339328-wizu3arz 11 58 2 2 CD cord-339328-wizu3arz 11 59 ] ] -RRB- cord-339328-wizu3arz 11 60 [ [ -LRB- cord-339328-wizu3arz 11 61 3 3 CD cord-339328-wizu3arz 11 62 ] ] -RRB- cord-339328-wizu3arz 11 63 [ [ -LRB- cord-339328-wizu3arz 11 64 4 4 CD cord-339328-wizu3arz 11 65 ] ] -RRB- cord-339328-wizu3arz 11 66 . . . cord-339328-wizu3arz 12 1 In in IN cord-339328-wizu3arz 12 2 2011 2011 CD cord-339328-wizu3arz 12 3 , , , cord-339328-wizu3arz 12 4 about about RB cord-339328-wizu3arz 12 5 722,000 722,000 CD cord-339328-wizu3arz 12 6 Americans Americans NNPS cord-339328-wizu3arz 12 7 developed develop VBN cord-339328-wizu3arz 12 8 hospital hospital NN cord-339328-wizu3arz 12 9 - - HYPH cord-339328-wizu3arz 12 10 acquired acquire VBN cord-339328-wizu3arz 12 11 infections infection NNS cord-339328-wizu3arz 12 12 , , , cord-339328-wizu3arz 12 13 resulting result VBG cord-339328-wizu3arz 12 14 in in IN cord-339328-wizu3arz 12 15 75,000 75,000 CD cord-339328-wizu3arz 12 16 deaths death NNS cord-339328-wizu3arz 12 17 in in IN cord-339328-wizu3arz 12 18 the the DT cord-339328-wizu3arz 12 19 USA USA NNP cord-339328-wizu3arz 12 20 . . . cord-339328-wizu3arz 13 1 Bacteria Bacteria NNS cord-339328-wizu3arz 13 2 , , , cord-339328-wizu3arz 13 3 notably notably RB cord-339328-wizu3arz 13 4 from from IN cord-339328-wizu3arz 13 5 the the DT cord-339328-wizu3arz 13 6 Enterobacteriaceae Enterobacteriaceae NNP cord-339328-wizu3arz 13 7 family family NN cord-339328-wizu3arz 13 8 ( ( -LRB- cord-339328-wizu3arz 13 9 26.8 26.8 CD cord-339328-wizu3arz 13 10 % % NN cord-339328-wizu3arz 13 11 ) ) -RRB- cord-339328-wizu3arz 13 12 , , , cord-339328-wizu3arz 13 13 Clostridium clostridium NN cord-339328-wizu3arz 13 14 difficile difficile NN cord-339328-wizu3arz 13 15 ( ( -LRB- cord-339328-wizu3arz 13 16 12.1 12.1 CD cord-339328-wizu3arz 13 17 % % NN cord-339328-wizu3arz 13 18 ) ) -RRB- cord-339328-wizu3arz 13 19 , , , cord-339328-wizu3arz 13 20 Staphylococcus Staphylococcus NNP cord-339328-wizu3arz 13 21 aureus aureus NN cord-339328-wizu3arz 13 22 ( ( -LRB- cord-339328-wizu3arz 13 23 10.7 10.7 CD cord-339328-wizu3arz 13 24 % % NN cord-339328-wizu3arz 13 25 ) ) -RRB- cord-339328-wizu3arz 13 26 , , , cord-339328-wizu3arz 13 27 and and CC cord-339328-wizu3arz 13 28 Pseudomonas Pseudomonas NNP cord-339328-wizu3arz 13 29 aeruginosa aeruginosa NN cord-339328-wizu3arz 13 30 ( ( -LRB- cord-339328-wizu3arz 13 31 7.1 7.1 CD cord-339328-wizu3arz 13 32 % % NN cord-339328-wizu3arz 13 33 ) ) -RRB- cord-339328-wizu3arz 13 34 , , , cord-339328-wizu3arz 13 35 accounted account VBD cord-339328-wizu3arz 13 36 for for IN cord-339328-wizu3arz 13 37 the the DT cord-339328-wizu3arz 13 38 majority majority NN cord-339328-wizu3arz 13 39 of of IN cord-339328-wizu3arz 13 40 these these DT cord-339328-wizu3arz 13 41 infections infection NNS cord-339328-wizu3arz 13 42 [ [ -LRB- cord-339328-wizu3arz 13 43 5 5 CD cord-339328-wizu3arz 13 44 , , , cord-339328-wizu3arz 13 45 6 6 CD cord-339328-wizu3arz 13 46 ] ] -RRB- cord-339328-wizu3arz 13 47 . . . cord-339328-wizu3arz 14 1 Similarly similarly RB cord-339328-wizu3arz 14 2 , , , cord-339328-wizu3arz 14 3 viral viral JJ cord-339328-wizu3arz 14 4 infections infection NNS cord-339328-wizu3arz 14 5 such such JJ cord-339328-wizu3arz 14 6 as as IN cord-339328-wizu3arz 14 7 influenza influenza NN cord-339328-wizu3arz 14 8 cause cause VB cord-339328-wizu3arz 14 9 millions million NNS cord-339328-wizu3arz 14 10 of of IN cord-339328-wizu3arz 14 11 new new JJ cord-339328-wizu3arz 14 12 cases case NNS cord-339328-wizu3arz 14 13 and and CC cord-339328-wizu3arz 14 14 several several JJ cord-339328-wizu3arz 14 15 thousand thousand CD cord-339328-wizu3arz 14 16 deaths death NNS cord-339328-wizu3arz 14 17 annually annually RB cord-339328-wizu3arz 14 18 in in IN cord-339328-wizu3arz 14 19 the the DT cord-339328-wizu3arz 14 20 USA USA NNP cord-339328-wizu3arz 14 21 [ [ -LRB- cord-339328-wizu3arz 14 22 7 7 CD cord-339328-wizu3arz 14 23 ] ] -RRB- cord-339328-wizu3arz 14 24 . . . cord-339328-wizu3arz 15 1 The the DT cord-339328-wizu3arz 15 2 burden burden NN cord-339328-wizu3arz 15 3 of of IN cord-339328-wizu3arz 15 4 hospital hospital NN cord-339328-wizu3arz 15 5 - - HYPH cord-339328-wizu3arz 15 6 acquired acquire VBN cord-339328-wizu3arz 15 7 and and CC cord-339328-wizu3arz 15 8 other other JJ cord-339328-wizu3arz 15 9 infections infection NNS cord-339328-wizu3arz 15 10 is be VBZ cord-339328-wizu3arz 15 11 substantially substantially RB cord-339328-wizu3arz 15 12 higher high JJR cord-339328-wizu3arz 15 13 globally globally RB cord-339328-wizu3arz 15 14 . . . cord-339328-wizu3arz 16 1 For for IN cord-339328-wizu3arz 16 2 example example NN cord-339328-wizu3arz 16 3 , , , cord-339328-wizu3arz 16 4 Mycobacterium Mycobacterium NNP cord-339328-wizu3arz 16 5 tuberculosis tuberculosis NN cord-339328-wizu3arz 16 6 , , , cord-339328-wizu3arz 16 7 the the DT cord-339328-wizu3arz 16 8 causative causative JJ cord-339328-wizu3arz 16 9 agent agent NN cord-339328-wizu3arz 16 10 for for IN cord-339328-wizu3arz 16 11 tuberculosis tuberculosis NN cord-339328-wizu3arz 16 12 ( ( -LRB- cord-339328-wizu3arz 16 13 TB TB NNP cord-339328-wizu3arz 16 14 ) ) -RRB- cord-339328-wizu3arz 16 15 , , , cord-339328-wizu3arz 16 16 was be VBD cord-339328-wizu3arz 16 17 responsible responsible JJ cord-339328-wizu3arz 16 18 for for IN cord-339328-wizu3arz 16 19 10.4 10.4 CD cord-339328-wizu3arz 16 20 and and CC cord-339328-wizu3arz 16 21 1.8 1.8 CD cord-339328-wizu3arz 16 22 million million CD cord-339328-wizu3arz 16 23 new new JJ cord-339328-wizu3arz 16 24 cases case NNS cord-339328-wizu3arz 16 25 and and CC cord-339328-wizu3arz 16 26 deaths death NNS cord-339328-wizu3arz 16 27 in in IN cord-339328-wizu3arz 16 28 2015 2015 CD cord-339328-wizu3arz 16 29 alone alone JJ cord-339328-wizu3arz 16 30 [ [ -LRB- cord-339328-wizu3arz 16 31 8 8 CD cord-339328-wizu3arz 16 32 ] ] -RRB- cord-339328-wizu3arz 16 33 . . . cord-339328-wizu3arz 17 1 The the DT cord-339328-wizu3arz 17 2 alarming alarming JJ cord-339328-wizu3arz 17 3 rise rise NN cord-339328-wizu3arz 17 4 of of IN cord-339328-wizu3arz 17 5 multi multi JJ cord-339328-wizu3arz 17 6 - - JJ cord-339328-wizu3arz 17 7 drug drug JJ cord-339328-wizu3arz 17 8 - - HYPH cord-339328-wizu3arz 17 9 resistant resistant JJ cord-339328-wizu3arz 17 10 ( ( -LRB- cord-339328-wizu3arz 17 11 MDR MDR NNP cord-339328-wizu3arz 17 12 ) ) -RRB- cord-339328-wizu3arz 17 13 and and CC cord-339328-wizu3arz 17 14 extensively extensively RB cord-339328-wizu3arz 17 15 drugresistant drugresistant JJ cord-339328-wizu3arz 17 16 ( ( -LRB- cord-339328-wizu3arz 17 17 XDR XDR NNP cord-339328-wizu3arz 17 18 ) ) -RRB- cord-339328-wizu3arz 17 19 strains strain NNS cord-339328-wizu3arz 17 20 , , , cord-339328-wizu3arz 17 21 as as RB cord-339328-wizu3arz 17 22 well well RB cord-339328-wizu3arz 17 23 as as IN cord-339328-wizu3arz 17 24 HIV HIV NNP cord-339328-wizu3arz 17 25 co co NN cord-339328-wizu3arz 17 26 - - NN cord-339328-wizu3arz 17 27 infection infection NN cord-339328-wizu3arz 17 28 , , , cord-339328-wizu3arz 17 29 continues continue VBZ cord-339328-wizu3arz 17 30 to to TO cord-339328-wizu3arz 17 31 fuel fuel VB cord-339328-wizu3arz 17 32 this this DT cord-339328-wizu3arz 17 33 epidemic epidemic NN cord-339328-wizu3arz 17 34 [ [ -LRB- cord-339328-wizu3arz 17 35 8 8 CD cord-339328-wizu3arz 17 36 ] ] -RRB- cord-339328-wizu3arz 17 37 [ [ -LRB- cord-339328-wizu3arz 17 38 9 9 CD cord-339328-wizu3arz 17 39 ] ] -RRB- cord-339328-wizu3arz 17 40 [ [ -LRB- cord-339328-wizu3arz 17 41 10 10 CD cord-339328-wizu3arz 17 42 ] ] -RRB- cord-339328-wizu3arz 17 43 . . . cord-339328-wizu3arz 18 1 Global global JJ cord-339328-wizu3arz 18 2 travel travel NN cord-339328-wizu3arz 18 3 and and CC cord-339328-wizu3arz 18 4 rapid rapid JJ cord-339328-wizu3arz 18 5 spread spread NN cord-339328-wizu3arz 18 6 of of IN cord-339328-wizu3arz 18 7 infections infection NNS cord-339328-wizu3arz 18 8 - - HYPH cord-339328-wizu3arz 18 9 swine swine NN cord-339328-wizu3arz 18 10 flu flu NN cord-339328-wizu3arz 18 11 , , , cord-339328-wizu3arz 18 12 SARS SARS NNP cord-339328-wizu3arz 18 13 - - HYPH cord-339328-wizu3arz 18 14 CoV CoV NNP cord-339328-wizu3arz 18 15 , , , cord-339328-wizu3arz 18 16 Ebola Ebola NNP cord-339328-wizu3arz 18 17 , , , cord-339328-wizu3arz 18 18 and and CC cord-339328-wizu3arz 18 19 Zika Zika NNP cord-339328-wizu3arz 18 20 virus virus NN cord-339328-wizu3arz 18 21 - - : cord-339328-wizu3arz 18 22 have have VBP cord-339328-wizu3arz 18 23 led lead VBN cord-339328-wizu3arz 18 24 to to IN cord-339328-wizu3arz 18 25 several several JJ cord-339328-wizu3arz 18 26 recent recent JJ cord-339328-wizu3arz 18 27 global global JJ cord-339328-wizu3arz 18 28 pandemics pandemic NNS cord-339328-wizu3arz 18 29 [ [ -LRB- cord-339328-wizu3arz 18 30 11 11 CD cord-339328-wizu3arz 18 31 , , , cord-339328-wizu3arz 18 32 12 12 CD cord-339328-wizu3arz 18 33 ] ] -RRB- cord-339328-wizu3arz 18 34 . . . cord-339328-wizu3arz 19 1 Finally finally RB cord-339328-wizu3arz 19 2 , , , cord-339328-wizu3arz 19 3 several several JJ cord-339328-wizu3arz 19 4 infectious infectious JJ cord-339328-wizu3arz 19 5 pathogens pathogen NNS cord-339328-wizu3arz 19 6 , , , cord-339328-wizu3arz 19 7 e.g. e.g. RB cord-339328-wizu3arz 19 8 , , , cord-339328-wizu3arz 19 9 Yersinia Yersinia NNP cord-339328-wizu3arz 19 10 pestis pestis NN cord-339328-wizu3arz 19 11 ( ( -LRB- cord-339328-wizu3arz 19 12 causes cause VBZ cord-339328-wizu3arz 19 13 plague plague NN cord-339328-wizu3arz 19 14 ) ) -RRB- cord-339328-wizu3arz 19 15 from from IN cord-339328-wizu3arz 19 16 the the DT cord-339328-wizu3arz 19 17 Enterobacteriaceae Enterobacteriaceae NNP cord-339328-wizu3arz 19 18 family family NN cord-339328-wizu3arz 19 19 , , , cord-339328-wizu3arz 19 20 are be VBP cord-339328-wizu3arz 19 21 also also RB cord-339328-wizu3arz 19 22 recognized recognize VBN cord-339328-wizu3arz 19 23 as as IN cord-339328-wizu3arz 19 24 biothreat biothreat NN cord-339328-wizu3arz 19 25 agents agent NNS cord-339328-wizu3arz 19 26 [ [ -LRB- cord-339328-wizu3arz 19 27 13 13 CD cord-339328-wizu3arz 19 28 ] ] -RRB- cord-339328-wizu3arz 19 29 . . . cord-339328-wizu3arz 20 1 these these DT cord-339328-wizu3arz 20 2 processes process NNS cord-339328-wizu3arz 20 3 in in IN cord-339328-wizu3arz 20 4 vivo vivo NN cord-339328-wizu3arz 20 5 is be VBZ cord-339328-wizu3arz 20 6 a a DT cord-339328-wizu3arz 20 7 key key NN cord-339328-wizu3arz 20 8 to to IN cord-339328-wizu3arz 20 9 controlling control VBG cord-339328-wizu3arz 20 10 infections infection NNS cord-339328-wizu3arz 20 11 . . . cord-339328-wizu3arz 21 1 Therefore therefore RB cord-339328-wizu3arz 21 2 , , , cord-339328-wizu3arz 21 3 the the DT cord-339328-wizu3arz 21 4 World World NNP cord-339328-wizu3arz 21 5 Molecular Molecular NNP cord-339328-wizu3arz 21 6 Imaging Imaging NNP cord-339328-wizu3arz 21 7 Society Society NNP cord-339328-wizu3arz 21 8 has have VBZ cord-339328-wizu3arz 21 9 made make VBN cord-339328-wizu3arz 21 10 a a DT cord-339328-wizu3arz 21 11 commitment commitment NN cord-339328-wizu3arz 21 12 for for IN cord-339328-wizu3arz 21 13 advancing advance VBG cord-339328-wizu3arz 21 14 imaging imaging NN cord-339328-wizu3arz 21 15 tools tool NNS cord-339328-wizu3arz 21 16 for for IN cord-339328-wizu3arz 21 17 infectious infectious JJ cord-339328-wizu3arz 21 18 diseases disease NNS cord-339328-wizu3arz 21 19 and and CC cord-339328-wizu3arz 21 20 inflammation inflammation NN cord-339328-wizu3arz 21 21 by by IN cord-339328-wizu3arz 21 22 creating create VBG cord-339328-wizu3arz 21 23 the the DT cord-339328-wizu3arz 21 24 Imaging Imaging NNP cord-339328-wizu3arz 21 25 of of IN cord-339328-wizu3arz 21 26 Infection Infection NNP cord-339328-wizu3arz 21 27 Interest Interest NNP cord-339328-wizu3arz 21 28 Group Group NNP cord-339328-wizu3arz 21 29 ( ( -LRB- cord-339328-wizu3arz 21 30 IOI IOI NNP cord-339328-wizu3arz 21 31 - - HYPH cord-339328-wizu3arz 21 32 IG IG NNP cord-339328-wizu3arz 21 33 ) ) -RRB- cord-339328-wizu3arz 21 34 . . . cord-339328-wizu3arz 22 1 This this DT cord-339328-wizu3arz 22 2 interest interest NN cord-339328-wizu3arz 22 3 group group NN cord-339328-wizu3arz 22 4 is be VBZ cord-339328-wizu3arz 22 5 tasked task VBN cord-339328-wizu3arz 22 6 with with IN cord-339328-wizu3arz 22 7 the the DT cord-339328-wizu3arz 22 8 mission mission NN cord-339328-wizu3arz 22 9 to to TO cord-339328-wizu3arz 22 10 globally globally RB cord-339328-wizu3arz 22 11 advance advance VB cord-339328-wizu3arz 22 12 the the DT cord-339328-wizu3arz 22 13 development development NN cord-339328-wizu3arz 22 14 of of IN cord-339328-wizu3arz 22 15 new new JJ cord-339328-wizu3arz 22 16 imaging imaging NN cord-339328-wizu3arz 22 17 technologies technology NNS cord-339328-wizu3arz 22 18 for for IN cord-339328-wizu3arz 22 19 infectious infectious JJ cord-339328-wizu3arz 22 20 diseases disease NNS cord-339328-wizu3arz 22 21 and and CC cord-339328-wizu3arz 22 22 the the DT cord-339328-wizu3arz 22 23 translation translation NN cord-339328-wizu3arz 22 24 of of IN cord-339328-wizu3arz 22 25 effective effective JJ cord-339328-wizu3arz 22 26 imaging imaging NN cord-339328-wizu3arz 22 27 tools tool NNS cord-339328-wizu3arz 22 28 to to TO cord-339328-wizu3arz 22 29 provide provide VB cord-339328-wizu3arz 22 30 unique unique JJ cord-339328-wizu3arz 22 31 insights insight NNS cord-339328-wizu3arz 22 32 into into IN cord-339328-wizu3arz 22 33 disease disease NN cord-339328-wizu3arz 22 34 mechanisms mechanism NNS cord-339328-wizu3arz 22 35 , , , cord-339328-wizu3arz 22 36 enable enable VBP cord-339328-wizu3arz 22 37 drug drug NN cord-339328-wizu3arz 22 38 and and CC cord-339328-wizu3arz 22 39 vaccine vaccine NN cord-339328-wizu3arz 22 40 development development NN cord-339328-wizu3arz 22 41 , , , cord-339328-wizu3arz 22 42 guide guide NN cord-339328-wizu3arz 22 43 treatments treatment NNS cord-339328-wizu3arz 22 44 , , , cord-339328-wizu3arz 22 45 and and CC cord-339328-wizu3arz 22 46 benefit benefit NN cord-339328-wizu3arz 22 47 patients patient NNS cord-339328-wizu3arz 22 48 ( ( -LRB- cord-339328-wizu3arz 22 49 Fig Fig NNP cord-339328-wizu3arz 22 50 . . . cord-339328-wizu3arz 22 51 1 1 CD cord-339328-wizu3arz 22 52 ) ) -RRB- cord-339328-wizu3arz 22 53 . . . cord-339328-wizu3arz 23 1 As as IN cord-339328-wizu3arz 23 2 part part NN cord-339328-wizu3arz 23 3 of of IN cord-339328-wizu3arz 23 4 these these DT cord-339328-wizu3arz 23 5 efforts effort NNS cord-339328-wizu3arz 23 6 , , , cord-339328-wizu3arz 23 7 the the DT cord-339328-wizu3arz 23 8 IOI IOI NNP cord-339328-wizu3arz 23 9 - - HYPH cord-339328-wizu3arz 23 10 IG IG NNP cord-339328-wizu3arz 23 11 organized organize VBD cord-339328-wizu3arz 23 12 several several JJ cord-339328-wizu3arz 23 13 sessions session NNS cord-339328-wizu3arz 23 14 at at IN cord-339328-wizu3arz 23 15 the the DT cord-339328-wizu3arz 23 16 2016 2016 CD cord-339328-wizu3arz 23 17 World World NNP cord-339328-wizu3arz 23 18 Molecular Molecular NNP cord-339328-wizu3arz 23 19 Imaging Imaging NNP cord-339328-wizu3arz 23 20 Congress Congress NNP cord-339328-wizu3arz 23 21 ( ( -LRB- cord-339328-wizu3arz 23 22 WMIC WMIC NNP cord-339328-wizu3arz 23 23 ) ) -RRB- cord-339328-wizu3arz 23 24 . . . cord-339328-wizu3arz 24 1 This this DT cord-339328-wizu3arz 24 2 included include VBD cord-339328-wizu3arz 24 3 a a DT cord-339328-wizu3arz 24 4 1-day 1-day JJ cord-339328-wizu3arz 24 5 workshop workshop NN cord-339328-wizu3arz 24 6 focused focus VBN cord-339328-wizu3arz 24 7 on on IN cord-339328-wizu3arz 24 8 imaging imaging NN cord-339328-wizu3arz 24 9 of of IN cord-339328-wizu3arz 24 10 infection infection NN cord-339328-wizu3arz 24 11 and and CC cord-339328-wizu3arz 24 12 inflammation inflammation NN cord-339328-wizu3arz 24 13 , , , cord-339328-wizu3arz 24 14 which which WDT cord-339328-wizu3arz 24 15 brought bring VBD cord-339328-wizu3arz 24 16 together together RB cord-339328-wizu3arz 24 17 individuals individual NNS cord-339328-wizu3arz 24 18 from from IN cord-339328-wizu3arz 24 19 multiple multiple JJ cord-339328-wizu3arz 24 20 scientific scientific JJ cord-339328-wizu3arz 24 21 disciplines discipline NNS cord-339328-wizu3arz 24 22 and and CC cord-339328-wizu3arz 24 23 highlighted highlight VBD cord-339328-wizu3arz 24 24 the the DT cord-339328-wizu3arz 24 25 latest late JJS cord-339328-wizu3arz 24 26 developments development NNS cord-339328-wizu3arz 24 27 in in IN cord-339328-wizu3arz 24 28 the the DT cord-339328-wizu3arz 24 29 field field NN cord-339328-wizu3arz 24 30 . . . cord-339328-wizu3arz 25 1 In in IN cord-339328-wizu3arz 25 2 addition addition NN cord-339328-wizu3arz 25 3 , , , cord-339328-wizu3arz 25 4 the the DT cord-339328-wizu3arz 25 5 workshop workshop NN cord-339328-wizu3arz 25 6 also also RB cord-339328-wizu3arz 25 7 had have VBD cord-339328-wizu3arz 25 8 a a DT cord-339328-wizu3arz 25 9 panel panel NN cord-339328-wizu3arz 25 10 discussion discussion NN cord-339328-wizu3arz 25 11 on on IN cord-339328-wizu3arz 25 12 the the DT cord-339328-wizu3arz 25 13 challenges challenge NNS cord-339328-wizu3arz 25 14 in in IN cord-339328-wizu3arz 25 15 funding funding NN cord-339328-wizu3arz 25 16 research research NN cord-339328-wizu3arz 25 17 , , , cord-339328-wizu3arz 25 18 with with IN cord-339328-wizu3arz 25 19 panelists panelist NNS cord-339328-wizu3arz 25 20 from from IN cord-339328-wizu3arz 25 21 the the DT cord-339328-wizu3arz 25 22 US US NNP cord-339328-wizu3arz 25 23 National National NNP cord-339328-wizu3arz 25 24 Institutes Institutes NNPS cord-339328-wizu3arz 25 25 of of IN cord-339328-wizu3arz 25 26 Health Health NNP cord-339328-wizu3arz 25 27 . . . cord-339328-wizu3arz 26 1 A a DT cord-339328-wizu3arz 26 2 similar similar JJ cord-339328-wizu3arz 26 3 workshop workshop NN cord-339328-wizu3arz 26 4 is be VBZ cord-339328-wizu3arz 26 5 planned plan VBN cord-339328-wizu3arz 26 6 at at IN cord-339328-wizu3arz 26 7 the the DT cord-339328-wizu3arz 26 8 2017 2017 CD cord-339328-wizu3arz 26 9 WMIC WMIC NNP cord-339328-wizu3arz 26 10 ( ( -LRB- cord-339328-wizu3arz 26 11 Philadelphia Philadelphia NNP cord-339328-wizu3arz 26 12 , , , cord-339328-wizu3arz 26 13 PA PA NNP cord-339328-wizu3arz 26 14 ) ) -RRB- cord-339328-wizu3arz 26 15 and and CC cord-339328-wizu3arz 26 16 will will MD cord-339328-wizu3arz 26 17 focus focus VB cord-339328-wizu3arz 26 18 on on IN cord-339328-wizu3arz 26 19 leveraging leverage VBG cord-339328-wizu3arz 26 20 current current JJ cord-339328-wizu3arz 26 21 resources resource NNS cord-339328-wizu3arz 26 22 , , , cord-339328-wizu3arz 26 23 promoting promote VBG cord-339328-wizu3arz 26 24 collaborations collaboration NNS cord-339328-wizu3arz 26 25 , , , cord-339328-wizu3arz 26 26 clinical clinical JJ cord-339328-wizu3arz 26 27 translation translation NN cord-339328-wizu3arz 26 28 , , , cord-339328-wizu3arz 26 29 and and CC cord-339328-wizu3arz 26 30 finding find VBG cord-339328-wizu3arz 26 31 strategies strategy NNS cord-339328-wizu3arz 26 32 to to TO cord-339328-wizu3arz 26 33 overcome overcome VB cord-339328-wizu3arz 26 34 the the DT cord-339328-wizu3arz 26 35 challenges challenge NNS cord-339328-wizu3arz 26 36 in in IN cord-339328-wizu3arz 26 37 funding fund VBG cord-339328-wizu3arz 26 38 research research NN cord-339328-wizu3arz 26 39 in in IN cord-339328-wizu3arz 26 40 this this DT cord-339328-wizu3arz 26 41 emerging emerge VBG cord-339328-wizu3arz 26 42 field field NN cord-339328-wizu3arz 26 43 . . . cord-339328-wizu3arz 27 1 Rapid rapid JJ cord-339328-wizu3arz 27 2 and and CC cord-339328-wizu3arz 27 3 accurate accurate JJ cord-339328-wizu3arz 27 4 diagnosis diagnosis NN cord-339328-wizu3arz 27 5 and and CC cord-339328-wizu3arz 27 6 localization localization NN cord-339328-wizu3arz 27 7 of of IN cord-339328-wizu3arz 27 8 infections infection NNS cord-339328-wizu3arz 27 9 are be VBP cord-339328-wizu3arz 27 10 essential essential JJ cord-339328-wizu3arz 27 11 for for IN cord-339328-wizu3arz 27 12 effective effective JJ cord-339328-wizu3arz 27 13 early early JJ cord-339328-wizu3arz 27 14 interventions intervention NNS cord-339328-wizu3arz 27 15 and and CC cord-339328-wizu3arz 27 16 appropriate appropriate JJ cord-339328-wizu3arz 27 17 management management NN cord-339328-wizu3arz 27 18 . . . cord-339328-wizu3arz 28 1 However however RB cord-339328-wizu3arz 28 2 , , , cord-339328-wizu3arz 28 3 traditional traditional JJ cord-339328-wizu3arz 28 4 diagnostic diagnostic JJ cord-339328-wizu3arz 28 5 tools tool NNS cord-339328-wizu3arz 28 6 , , , cord-339328-wizu3arz 28 7 namely namely RB cord-339328-wizu3arz 28 8 microscopy microscopy NN cord-339328-wizu3arz 28 9 , , , cord-339328-wizu3arz 28 10 microbiology microbiology NN cord-339328-wizu3arz 28 11 , , , cord-339328-wizu3arz 28 12 and and CC cord-339328-wizu3arz 28 13 molecular molecular JJ cord-339328-wizu3arz 28 14 techniques technique NNS cord-339328-wizu3arz 28 15 , , , cord-339328-wizu3arz 28 16 are be VBP cord-339328-wizu3arz 28 17 dependent dependent JJ cord-339328-wizu3arz 28 18 upon upon IN cord-339328-wizu3arz 28 19 sampling sampling NN cord-339328-wizu3arz 28 20 suspected suspect VBN cord-339328-wizu3arz 28 21 sites site NNS cord-339328-wizu3arz 28 22 of of IN cord-339328-wizu3arz 28 23 infection infection NN cord-339328-wizu3arz 28 24 , , , cord-339328-wizu3arz 28 25 often often RB cord-339328-wizu3arz 28 26 blindly blindly RB cord-339328-wizu3arz 28 27 , , , cord-339328-wizu3arz 28 28 and and CC cord-339328-wizu3arz 28 29 then then RB cord-339328-wizu3arz 28 30 performing perform VBG cord-339328-wizu3arz 28 31 assays assay NNS cord-339328-wizu3arz 28 32 that that WDT cord-339328-wizu3arz 28 33 can can MD cord-339328-wizu3arz 28 34 be be VB cord-339328-wizu3arz 28 35 time time NN cord-339328-wizu3arz 28 36 consuming consume VBG cord-339328-wizu3arz 28 37 . . . cord-339328-wizu3arz 29 1 While while IN cord-339328-wizu3arz 29 2 major major JJ cord-339328-wizu3arz 29 3 advances advance NNS cord-339328-wizu3arz 29 4 are be VBP cord-339328-wizu3arz 29 5 being be VBG cord-339328-wizu3arz 29 6 made make VBN cord-339328-wizu3arz 29 7 in in IN cord-339328-wizu3arz 29 8 the the DT cord-339328-wizu3arz 29 9 application application NN cord-339328-wizu3arz 29 10 of of IN cord-339328-wizu3arz 29 11 molecular molecular JJ cord-339328-wizu3arz 29 12 techniques technique NNS cord-339328-wizu3arz 29 13 such such JJ cord-339328-wizu3arz 29 14 as as IN cord-339328-wizu3arz 29 15 nucleic nucleic JJ cord-339328-wizu3arz 29 16 acid acid NN cord-339328-wizu3arz 29 17 amplification amplification NN cord-339328-wizu3arz 29 18 ( ( -LRB- cord-339328-wizu3arz 29 19 NAA NAA NNP cord-339328-wizu3arz 29 20 ) ) -RRB- cord-339328-wizu3arz 29 21 , , , cord-339328-wizu3arz 29 22 deep deep JJ cord-339328-wizu3arz 29 23 sequencing sequencing NN cord-339328-wizu3arz 29 24 , , , cord-339328-wizu3arz 29 25 and and CC cord-339328-wizu3arz 29 26 matrix matrix NN cord-339328-wizu3arz 29 27 - - HYPH cord-339328-wizu3arz 29 28 assisted assist VBN cord-339328-wizu3arz 29 29 laser laser NN cord-339328-wizu3arz 29 30 desorption desorption NN cord-339328-wizu3arz 29 31 / / SYM cord-339328-wizu3arz 29 32 ionization ionization NN cord-339328-wizu3arz 29 33 , , , cord-339328-wizu3arz 29 34 they -PRON- PRP cord-339328-wizu3arz 29 35 are be VBP cord-339328-wizu3arz 29 36 all all RB cord-339328-wizu3arz 29 37 dependent dependent JJ cord-339328-wizu3arz 29 38 on on IN cord-339328-wizu3arz 29 39 the the DT cord-339328-wizu3arz 29 40 availability availability NN cord-339328-wizu3arz 29 41 of of IN cord-339328-wizu3arz 29 42 a a DT cord-339328-wizu3arz 29 43 relevant relevant JJ cord-339328-wizu3arz 29 44 clinical clinical JJ cord-339328-wizu3arz 29 45 sample sample NN cord-339328-wizu3arz 29 46 . . . cord-339328-wizu3arz 30 1 Easily easily RB cord-339328-wizu3arz 30 2 obtained obtain VBD cord-339328-wizu3arz 30 3 clinical clinical JJ cord-339328-wizu3arz 30 4 samples sample NNS cord-339328-wizu3arz 30 5 such such JJ cord-339328-wizu3arz 30 6 as as IN cord-339328-wizu3arz 30 7 blood blood NN cord-339328-wizu3arz 30 8 or or CC cord-339328-wizu3arz 30 9 urine urine NN cord-339328-wizu3arz 30 10 may may MD cord-339328-wizu3arz 30 11 lack lack VB cord-339328-wizu3arz 30 12 relevance relevance NN cord-339328-wizu3arz 30 13 and and CC cord-339328-wizu3arz 30 14 not not RB cord-339328-wizu3arz 30 15 contribute contribute VB cord-339328-wizu3arz 30 16 to to IN cord-339328-wizu3arz 30 17 a a DT cord-339328-wizu3arz 30 18 specific specific JJ cord-339328-wizu3arz 30 19 diagnosis diagnosis NN cord-339328-wizu3arz 30 20 , , , cord-339328-wizu3arz 30 21 especially especially RB cord-339328-wizu3arz 30 22 with with IN cord-339328-wizu3arz 30 23 deep deep RB cord-339328-wizu3arz 30 24 - - HYPH cord-339328-wizu3arz 30 25 seated seat VBN cord-339328-wizu3arz 30 26 infections infection NNS cord-339328-wizu3arz 30 27 , , , cord-339328-wizu3arz 30 28 and and CC cord-339328-wizu3arz 30 29 invasive invasive JJ cord-339328-wizu3arz 30 30 biopsies biopsy NNS cord-339328-wizu3arz 30 31 are be VBP cord-339328-wizu3arz 30 32 often often RB cord-339328-wizu3arz 30 33 required require VBN cord-339328-wizu3arz 30 34 . . . cord-339328-wizu3arz 31 1 Biopsies biopsy NNS cord-339328-wizu3arz 31 2 can can MD cord-339328-wizu3arz 31 3 be be VB cord-339328-wizu3arz 31 4 costly costly JJ cord-339328-wizu3arz 31 5 , , , cord-339328-wizu3arz 31 6 risky risky JJ cord-339328-wizu3arz 31 7 ( ( -LRB- cord-339328-wizu3arz 31 8 anesthesia anesthesia NN cord-339328-wizu3arz 31 9 , , , cord-339328-wizu3arz 31 10 dangers danger NNS cord-339328-wizu3arz 31 11 of of IN cord-339328-wizu3arz 31 12 surgery surgery NN cord-339328-wizu3arz 31 13 ) ) -RRB- cord-339328-wizu3arz 31 14 , , , cord-339328-wizu3arz 31 15 and and CC cord-339328-wizu3arz 31 16 prone prone JJ cord-339328-wizu3arz 31 17 to to IN cord-339328-wizu3arz 31 18 incorrect incorrect JJ cord-339328-wizu3arz 31 19 sampling sampling NN cord-339328-wizu3arz 31 20 ( ( -LRB- cord-339328-wizu3arz 31 21 limited limit VBN cord-339328-wizu3arz 31 22 to to IN cord-339328-wizu3arz 31 23 the the DT cord-339328-wizu3arz 31 24 tip tip NN cord-339328-wizu3arz 31 25 of of IN cord-339328-wizu3arz 31 26 the the DT cord-339328-wizu3arz 31 27 biopsy biopsy NNP cord-339328-wizu3arz 31 28 needle needle NN cord-339328-wizu3arz 31 29 ) ) -RRB- cord-339328-wizu3arz 31 30 as as RB cord-339328-wizu3arz 31 31 well well RB cord-339328-wizu3arz 31 32 as as IN cord-339328-wizu3arz 31 33 lead lead NN cord-339328-wizu3arz 31 34 to to IN cord-339328-wizu3arz 31 35 the the DT cord-339328-wizu3arz 31 36 introduction introduction NN cord-339328-wizu3arz 31 37 of of IN cord-339328-wizu3arz 31 38 artifacts artifact NNS cord-339328-wizu3arz 31 39 or or CC cord-339328-wizu3arz 31 40 contamination contamination NN cord-339328-wizu3arz 31 41 . . . cord-339328-wizu3arz 32 1 Molecular molecular JJ cord-339328-wizu3arz 32 2 imaging imaging NN cord-339328-wizu3arz 32 3 techniques technique NNS cord-339328-wizu3arz 32 4 detect detect VBP cord-339328-wizu3arz 32 5 crucial crucial JJ cord-339328-wizu3arz 32 6 biological biological JJ cord-339328-wizu3arz 32 7 and and CC cord-339328-wizu3arz 32 8 biochemical biochemical JJ cord-339328-wizu3arz 32 9 changes change NNS cord-339328-wizu3arz 32 10 at at IN cord-339328-wizu3arz 32 11 the the DT cord-339328-wizu3arz 32 12 sites site NNS cord-339328-wizu3arz 32 13 of of IN cord-339328-wizu3arz 32 14 infection infection NN cord-339328-wizu3arz 32 15 , , , cord-339328-wizu3arz 32 16 often often RB cord-339328-wizu3arz 32 17 at at IN cord-339328-wizu3arz 32 18 the the DT cord-339328-wizu3arz 32 19 earliest early JJS cord-339328-wizu3arz 32 20 phase phase NN cord-339328-wizu3arz 32 21 of of IN cord-339328-wizu3arz 32 22 the the DT cord-339328-wizu3arz 32 23 disease disease NN cord-339328-wizu3arz 32 24 , , , cord-339328-wizu3arz 32 25 thereby thereby RB cord-339328-wizu3arz 32 26 allowing allow VBG cord-339328-wizu3arz 32 27 the the DT cord-339328-wizu3arz 32 28 clinician clinician NN cord-339328-wizu3arz 32 29 to to TO cord-339328-wizu3arz 32 30 promptly promptly RB cord-339328-wizu3arz 32 31 identify identify VB cord-339328-wizu3arz 32 32 not not RB cord-339328-wizu3arz 32 33 only only RB cord-339328-wizu3arz 32 34 the the DT cord-339328-wizu3arz 32 35 infective infective JJ cord-339328-wizu3arz 32 36 or or CC cord-339328-wizu3arz 32 37 inflammatory inflammatory JJ cord-339328-wizu3arz 32 38 focus focus NN cord-339328-wizu3arz 32 39 but but CC cord-339328-wizu3arz 32 40 also also RB cord-339328-wizu3arz 32 41 the the DT cord-339328-wizu3arz 32 42 class class NN cord-339328-wizu3arz 32 43 of of IN cord-339328-wizu3arz 32 44 the the DT cord-339328-wizu3arz 32 45 causative causative JJ cord-339328-wizu3arz 32 46 pathogen pathogen NN cord-339328-wizu3arz 32 47 and and CC cord-339328-wizu3arz 32 48 establish establish VB cord-339328-wizu3arz 32 49 the the DT cord-339328-wizu3arz 32 50 best good JJS cord-339328-wizu3arz 32 51 therapeutic therapeutic JJ cord-339328-wizu3arz 32 52 approach approach NN cord-339328-wizu3arz 32 53 for for IN cord-339328-wizu3arz 32 54 patients patient NNS cord-339328-wizu3arz 32 55 . . . cord-339328-wizu3arz 33 1 Tomographic tomographic JJ cord-339328-wizu3arz 33 2 imaging imaging NN cord-339328-wizu3arz 33 3 can can MD cord-339328-wizu3arz 33 4 evaluate evaluate VB cord-339328-wizu3arz 33 5 disease disease NN cord-339328-wizu3arz 33 6 processes process NNS cord-339328-wizu3arz 33 7 deep deep RB cord-339328-wizu3arz 33 8 within within IN cord-339328-wizu3arz 33 9 the the DT cord-339328-wizu3arz 33 10 body body NN cord-339328-wizu3arz 33 11 , , , cord-339328-wizu3arz 33 12 noninvasively noninvasively RB cord-339328-wizu3arz 33 13 and and CC cord-339328-wizu3arz 33 14 rapidly rapidly RB cord-339328-wizu3arz 33 15 . . . cord-339328-wizu3arz 34 1 Moreover moreover RB cord-339328-wizu3arz 34 2 , , , cord-339328-wizu3arz 34 3 the the DT cord-339328-wizu3arz 34 4 ability ability NN cord-339328-wizu3arz 34 5 of of IN cord-339328-wizu3arz 34 6 imaging image VBG cord-339328-wizu3arz 34 7 to to TO cord-339328-wizu3arz 34 8 conduct conduct VB cord-339328-wizu3arz 34 9 noninvasive noninvasive JJ cord-339328-wizu3arz 34 10 , , , cord-339328-wizu3arz 34 11 longitudinal longitudinal JJ cord-339328-wizu3arz 34 12 assessments assessment NNS cord-339328-wizu3arz 34 13 in in IN cord-339328-wizu3arz 34 14 the the DT cord-339328-wizu3arz 34 15 same same JJ cord-339328-wizu3arz 34 16 individual individual NN cord-339328-wizu3arz 34 17 is be VBZ cord-339328-wizu3arz 34 18 a a DT cord-339328-wizu3arz 34 19 fundamental fundamental JJ cord-339328-wizu3arz 34 20 advantage advantage NN cord-339328-wizu3arz 34 21 over over IN cord-339328-wizu3arz 34 22 current current JJ cord-339328-wizu3arz 34 23 traditional traditional JJ cord-339328-wizu3arz 34 24 tools tool NNS cord-339328-wizu3arz 34 25 . . . cord-339328-wizu3arz 35 1 Other other JJ cord-339328-wizu3arz 35 2 major major JJ cord-339328-wizu3arz 35 3 advantages advantage NNS cord-339328-wizu3arz 35 4 of of IN cord-339328-wizu3arz 35 5 imaging imaging NN cord-339328-wizu3arz 35 6 are be VBP cord-339328-wizu3arz 35 7 its -PRON- PRP$ cord-339328-wizu3arz 35 8 ability ability NN cord-339328-wizu3arz 35 9 to to TO cord-339328-wizu3arz 35 10 provide provide VB cord-339328-wizu3arz 35 11 a a DT cord-339328-wizu3arz 35 12 holistic holistic JJ cord-339328-wizu3arz 35 13 , , , cord-339328-wizu3arz 35 14 three three CD cord-339328-wizu3arz 35 15 - - HYPH cord-339328-wizu3arz 35 16 dimensional dimensional JJ cord-339328-wizu3arz 35 17 assessment assessment NN cord-339328-wizu3arz 35 18 of of IN cord-339328-wizu3arz 35 19 the the DT cord-339328-wizu3arz 35 20 whole whole JJ cord-339328-wizu3arz 35 21 organ organ NN cord-339328-wizu3arz 35 22 or or CC cord-339328-wizu3arz 35 23 body body NN cord-339328-wizu3arz 35 24 , , , cord-339328-wizu3arz 35 25 less less RBR cord-339328-wizu3arz 35 26 likely likely JJ cord-339328-wizu3arz 35 27 to to TO cord-339328-wizu3arz 35 28 be be VB cord-339328-wizu3arz 35 29 limited limit VBN cord-339328-wizu3arz 35 30 by by IN cord-339328-wizu3arz 35 31 sampling sampling NN cord-339328-wizu3arz 35 32 errors error NNS cord-339328-wizu3arz 35 33 and and CC cord-339328-wizu3arz 35 34 co co NN cord-339328-wizu3arz 35 35 - - NN cord-339328-wizu3arz 35 36 relating relating JJ cord-339328-wizu3arz 35 37 well well RB cord-339328-wizu3arz 35 38 with with IN cord-339328-wizu3arz 35 39 the the DT cord-339328-wizu3arz 35 40 overall overall JJ cord-339328-wizu3arz 35 41 disease disease NN cord-339328-wizu3arz 35 42 process process NN cord-339328-wizu3arz 35 43 ( ( -LRB- cord-339328-wizu3arz 35 44 Table table NN cord-339328-wizu3arz 35 45 1 1 CD cord-339328-wizu3arz 35 46 ) ) -RRB- cord-339328-wizu3arz 35 47 . . . cord-339328-wizu3arz 36 1 Selected select VBN cord-339328-wizu3arz 36 2 recent recent JJ cord-339328-wizu3arz 36 3 examples example NNS cord-339328-wizu3arz 36 4 highlighting highlight VBG cord-339328-wizu3arz 36 5 the the DT cord-339328-wizu3arz 36 6 unique unique JJ cord-339328-wizu3arz 36 7 role role NN cord-339328-wizu3arz 36 8 of of IN cord-339328-wizu3arz 36 9 imaging image VBG cord-339328-wizu3arz 36 10 in in IN cord-339328-wizu3arz 36 11 infectious infectious JJ cord-339328-wizu3arz 36 12 diseases disease NNS cord-339328-wizu3arz 36 13 are be VBP cord-339328-wizu3arz 36 14 briefly briefly RB cord-339328-wizu3arz 36 15 described describe VBN cord-339328-wizu3arz 36 16 in in IN cord-339328-wizu3arz 36 17 this this DT cord-339328-wizu3arz 36 18 overview overview NN cord-339328-wizu3arz 36 19 . . . cord-339328-wizu3arz 36 20 _SP cord-339328-wizu3arz 37 1 Optical optical JJ cord-339328-wizu3arz 37 2 imaging imaging NN cord-339328-wizu3arz 37 3 methods method NNS cord-339328-wizu3arz 37 4 have have VBP cord-339328-wizu3arz 37 5 been be VBN cord-339328-wizu3arz 37 6 used use VBN cord-339328-wizu3arz 37 7 extensively extensively RB cord-339328-wizu3arz 37 8 to to TO cord-339328-wizu3arz 37 9 study study VB cord-339328-wizu3arz 37 10 disease disease NN cord-339328-wizu3arz 37 11 pathogenesis pathogenesis NN cord-339328-wizu3arz 37 12 , , , cord-339328-wizu3arz 37 13 largely largely RB cord-339328-wizu3arz 37 14 in in IN cord-339328-wizu3arz 37 15 small small JJ cord-339328-wizu3arz 37 16 laboratory laboratory NN cord-339328-wizu3arz 37 17 animals animal NNS cord-339328-wizu3arz 37 18 . . . cord-339328-wizu3arz 38 1 For for IN cord-339328-wizu3arz 38 2 example example NN cord-339328-wizu3arz 38 3 , , , cord-339328-wizu3arz 38 4 real real JJ cord-339328-wizu3arz 38 5 - - HYPH cord-339328-wizu3arz 38 6 time time NN cord-339328-wizu3arz 38 7 analysis analysis NN cord-339328-wizu3arz 38 8 of of IN cord-339328-wizu3arz 38 9 Mycobacterium Mycobacterium NNP cord-339328-wizu3arz 38 10 marinum marinum IN cord-339328-wizu3arz 38 11 infection infection NN cord-339328-wizu3arz 38 12 in in IN cord-339328-wizu3arz 38 13 the the DT cord-339328-wizu3arz 38 14 transparent transparent JJ cord-339328-wizu3arz 38 15 zebrafish zebrafish NN cord-339328-wizu3arz 38 16 has have VBZ cord-339328-wizu3arz 38 17 provided provide VBN cord-339328-wizu3arz 38 18 new new JJ cord-339328-wizu3arz 38 19 insights insight NNS cord-339328-wizu3arz 38 20 into into IN cord-339328-wizu3arz 38 21 the the DT cord-339328-wizu3arz 38 22 temporal temporal JJ cord-339328-wizu3arz 38 23 kinetics kinetic NNS cord-339328-wizu3arz 38 24 of of IN cord-339328-wizu3arz 38 25 host host NN cord-339328-wizu3arz 38 26 - - HYPH cord-339328-wizu3arz 38 27 pathogen pathogen NN cord-339328-wizu3arz 38 28 interactions interaction NNS cord-339328-wizu3arz 38 29 [ [ -LRB- cord-339328-wizu3arz 38 30 14 14 CD cord-339328-wizu3arz 38 31 ] ] -RRB- cord-339328-wizu3arz 38 32 . . . cord-339328-wizu3arz 39 1 Similarly similarly RB cord-339328-wizu3arz 39 2 , , , cord-339328-wizu3arz 39 3 immune immune JJ cord-339328-wizu3arz 39 4 responses response NNS cord-339328-wizu3arz 39 5 to to IN cord-339328-wizu3arz 39 6 central central JJ cord-339328-wizu3arz 39 7 nervous nervous JJ cord-339328-wizu3arz 39 8 system system NN cord-339328-wizu3arz 40 1 ( ( -LRB- cord-339328-wizu3arz 40 2 CNS CNS NNP cord-339328-wizu3arz 40 3 ) ) -RRB- cord-339328-wizu3arz 40 4 viral viral JJ cord-339328-wizu3arz 40 5 infections infection NNS cord-339328-wizu3arz 40 6 were be VBD cord-339328-wizu3arz 40 7 visualized visualize VBN cord-339328-wizu3arz 40 8 in in IN cord-339328-wizu3arz 40 9 real real JJ cord-339328-wizu3arz 40 10 time time NN cord-339328-wizu3arz 40 11 using use VBG cord-339328-wizu3arz 40 12 intravital intravital NNP cord-339328-wizu3arz 40 13 twophoton twophoton NNP cord-339328-wizu3arz 40 14 laser laser NN cord-339328-wizu3arz 40 15 scanning scanning NN cord-339328-wizu3arz 40 16 microscopy microscopy NNP cord-339328-wizu3arz 40 17 [ [ -LRB- cord-339328-wizu3arz 40 18 15 15 CD cord-339328-wizu3arz 40 19 ] ] -RRB- cord-339328-wizu3arz 40 20 . . . cord-339328-wizu3arz 41 1 While while IN cord-339328-wizu3arz 41 2 highly highly RB cord-339328-wizu3arz 41 3 sensitive sensitive JJ cord-339328-wizu3arz 41 4 , , , cord-339328-wizu3arz 41 5 optical optical JJ cord-339328-wizu3arz 41 6 imaging imaging NN cord-339328-wizu3arz 41 7 is be VBZ cord-339328-wizu3arz 41 8 limited limit VBN cord-339328-wizu3arz 41 9 by by IN cord-339328-wizu3arz 41 10 the the DT cord-339328-wizu3arz 41 11 depth depth NN cord-339328-wizu3arz 41 12 of of IN cord-339328-wizu3arz 41 13 the the DT cord-339328-wizu3arz 41 14 signal signal NN cord-339328-wizu3arz 41 15 and and CC cord-339328-wizu3arz 41 16 is be VBZ cord-339328-wizu3arz 41 17 therefore therefore RB cord-339328-wizu3arz 41 18 well well RB cord-339328-wizu3arz 41 19 suited suited JJ cord-339328-wizu3arz 41 20 for for IN cord-339328-wizu3arz 41 21 the the DT cord-339328-wizu3arz 41 22 study study NN cord-339328-wizu3arz 41 23 of of IN cord-339328-wizu3arz 41 24 laboratory laboratory NN cord-339328-wizu3arz 41 25 animal animal NN cord-339328-wizu3arz 41 26 models model NNS cord-339328-wizu3arz 41 27 but but CC cord-339328-wizu3arz 41 28 has have VBZ cord-339328-wizu3arz 41 29 limited limit VBN cord-339328-wizu3arz 41 30 clinical clinical JJ cord-339328-wizu3arz 41 31 utility utility NN cord-339328-wizu3arz 41 32 . . . cord-339328-wizu3arz 42 1 The the DT cord-339328-wizu3arz 42 2 limited limited JJ cord-339328-wizu3arz 42 3 depth depth NN cord-339328-wizu3arz 42 4 of of IN cord-339328-wizu3arz 42 5 penetration penetration NN cord-339328-wizu3arz 42 6 of of IN cord-339328-wizu3arz 42 7 signal signal NN cord-339328-wizu3arz 42 8 is be VBZ cord-339328-wizu3arz 42 9 not not RB cord-339328-wizu3arz 42 10 a a DT cord-339328-wizu3arz 42 11 problem problem NN cord-339328-wizu3arz 42 12 using use VBG cord-339328-wizu3arz 42 13 nuclear nuclear JJ cord-339328-wizu3arz 42 14 medicine medicine NN cord-339328-wizu3arz 42 15 tools tool NNS cord-339328-wizu3arz 42 16 . . . cord-339328-wizu3arz 43 1 For for IN cord-339328-wizu3arz 43 2 example example NN cord-339328-wizu3arz 43 3 , , , cord-339328-wizu3arz 43 4 2-deoxy-2- 2-deoxy-2- CD cord-339328-wizu3arz 43 5 [ [ -LRB- cord-339328-wizu3arz 43 6 18 18 CD cord-339328-wizu3arz 43 7 F]fluoro F]fluoro NNP cord-339328-wizu3arz 43 8 - - HYPH cord-339328-wizu3arz 43 9 D d NN cord-339328-wizu3arz 43 10 - - HYPH cord-339328-wizu3arz 43 11 glucose glucose NN cord-339328-wizu3arz 43 12 ( ( -LRB- cord-339328-wizu3arz 43 13 [ [ -LRB- cord-339328-wizu3arz 43 14 18 18 CD cord-339328-wizu3arz 43 15 F]FDG f]fdg NN cord-339328-wizu3arz 43 16 ) ) -RRB- cord-339328-wizu3arz 44 1 positron positron NN cord-339328-wizu3arz 44 2 emission emission NN cord-339328-wizu3arz 44 3 tomography tomography NN cord-339328-wizu3arz 44 4 ( ( -LRB- cord-339328-wizu3arz 44 5 PET PET NNP cord-339328-wizu3arz 44 6 ) ) -RRB- cord-339328-wizu3arz 44 7 and and CC cord-339328-wizu3arz 44 8 computed compute VBN cord-339328-wizu3arz 44 9 tomography tomography NN cord-339328-wizu3arz 44 10 ( ( -LRB- cord-339328-wizu3arz 44 11 CT CT NNP cord-339328-wizu3arz 44 12 ) ) -RRB- cord-339328-wizu3arz 44 13 were be VBD cord-339328-wizu3arz 44 14 used use VBN cord-339328-wizu3arz 44 15 to to TO cord-339328-wizu3arz 44 16 monitor monitor VB cord-339328-wizu3arz 44 17 the the DT cord-339328-wizu3arz 44 18 spatial spatial JJ cord-339328-wizu3arz 44 19 evolution evolution NN cord-339328-wizu3arz 44 20 of of IN cord-339328-wizu3arz 44 21 individual individual JJ cord-339328-wizu3arz 44 22 pulmonary pulmonary JJ cord-339328-wizu3arz 44 23 lesions lesion NNS cord-339328-wizu3arz 44 24 in in IN cord-339328-wizu3arz 44 25 a a DT cord-339328-wizu3arz 44 26 cohort cohort NN cord-339328-wizu3arz 44 27 of of IN cord-339328-wizu3arz 44 28 infected infected JJ cord-339328-wizu3arz 44 29 mice mouse NNS cord-339328-wizu3arz 44 30 that that WDT cord-339328-wizu3arz 44 31 develops develop VBZ cord-339328-wizu3arz 44 32 TB TB NNP cord-339328-wizu3arz 44 33 lesions lesion NNS cord-339328-wizu3arz 44 34 akin akin JJ cord-339328-wizu3arz 44 35 to to IN cord-339328-wizu3arz 44 36 humans human NNS cord-339328-wizu3arz 44 37 [ [ -LRB- cord-339328-wizu3arz 44 38 16 16 CD cord-339328-wizu3arz 44 39 ] ] -RRB- cord-339328-wizu3arz 44 40 [ [ -LRB- cord-339328-wizu3arz 44 41 17 17 CD cord-339328-wizu3arz 44 42 ] ] -RRB- cord-339328-wizu3arz 44 43 [ [ -LRB- cord-339328-wizu3arz 44 44 18 18 CD cord-339328-wizu3arz 44 45 ] ] -RRB- cord-339328-wizu3arz 44 46 and and CC cord-339328-wizu3arz 44 47 study study VB cord-339328-wizu3arz 44 48 the the DT cord-339328-wizu3arz 44 49 temporal temporal JJ cord-339328-wizu3arz 44 50 evolution evolution NN cord-339328-wizu3arz 44 51 of of IN cord-339328-wizu3arz 44 52 reactivation reactivation NN cord-339328-wizu3arz 44 53 pulmonary pulmonary JJ cord-339328-wizu3arz 44 54 TB TB NNP cord-339328-wizu3arz 44 55 ( ( -LRB- cord-339328-wizu3arz 44 56 relapse relapse NN cord-339328-wizu3arz 44 57 ) ) -RRB- cord-339328-wizu3arz 44 58 [ [ -LRB- cord-339328-wizu3arz 44 59 19 19 CD cord-339328-wizu3arz 44 60 ] ] -RRB- cord-339328-wizu3arz 44 61 . . . cord-339328-wizu3arz 45 1 It -PRON- PRP cord-339328-wizu3arz 45 2 was be VBD cord-339328-wizu3arz 45 3 noted note VBN cord-339328-wizu3arz 45 4 that that IN cord-339328-wizu3arz 45 5 the the DT cord-339328-wizu3arz 45 6 fate fate NN cord-339328-wizu3arz 45 7 of of IN cord-339328-wizu3arz 45 8 individual individual JJ cord-339328-wizu3arz 45 9 pulmonary pulmonary JJ cord-339328-wizu3arz 45 10 lesions lesion NNS cord-339328-wizu3arz 45 11 in in IN cord-339328-wizu3arz 45 12 the the DT cord-339328-wizu3arz 45 13 same same JJ cord-339328-wizu3arz 45 14 animal animal NN cord-339328-wizu3arz 45 15 varied vary VBN cord-339328-wizu3arz 45 16 substantially substantially RB cord-339328-wizu3arz 45 17 . . . cord-339328-wizu3arz 46 1 More more RBR cord-339328-wizu3arz 46 2 interestingly interestingly RB cord-339328-wizu3arz 46 3 , , , cord-339328-wizu3arz 46 4 several several JJ cord-339328-wizu3arz 46 5 lesions lesion NNS cord-339328-wizu3arz 46 6 also also RB cord-339328-wizu3arz 46 7 arose arise VBD cord-339328-wizu3arz 46 8 de de FW cord-339328-wizu3arz 46 9 novo novo NNP cord-339328-wizu3arz 46 10 within within IN cord-339328-wizu3arz 46 11 regions region NNS cord-339328-wizu3arz 46 12 with with IN cord-339328-wizu3arz 46 13 no no DT cord-339328-wizu3arz 46 14 prior prior JJ cord-339328-wizu3arz 46 15 lesions lesion NNS cord-339328-wizu3arz 46 16 suggesting suggest VBG cord-339328-wizu3arz 46 17 that that IN cord-339328-wizu3arz 46 18 dormant dormant JJ cord-339328-wizu3arz 46 19 bacteria bacteria NNS cord-339328-wizu3arz 46 20 may may MD cord-339328-wizu3arz 46 21 also also RB cord-339328-wizu3arz 46 22 reside reside VB cord-339328-wizu3arz 46 23 outside outside IN cord-339328-wizu3arz 46 24 TB TB NNP cord-339328-wizu3arz 46 25 lesions lesion NNS cord-339328-wizu3arz 46 26 . . . cord-339328-wizu3arz 47 1 Similar similar JJ cord-339328-wizu3arz 47 2 variability variability NN cord-339328-wizu3arz 47 3 of of IN cord-339328-wizu3arz 47 4 TB TB NNP cord-339328-wizu3arz 47 5 lesion lesion NN cord-339328-wizu3arz 47 6 within within IN cord-339328-wizu3arz 47 7 the the DT cord-339328-wizu3arz 47 8 same same JJ cord-339328-wizu3arz 47 9 host host NN cord-339328-wizu3arz 47 10 was be VBD cord-339328-wizu3arz 47 11 also also RB cord-339328-wizu3arz 47 12 reported report VBN cord-339328-wizu3arz 47 13 in in IN cord-339328-wizu3arz 47 14 non non JJ cord-339328-wizu3arz 47 15 - - JJ cord-339328-wizu3arz 47 16 human human JJ cord-339328-wizu3arz 47 17 primates primate NNS cord-339328-wizu3arz 47 18 [ [ -LRB- cord-339328-wizu3arz 47 19 20 20 CD cord-339328-wizu3arz 47 20 ] ] -RRB- cord-339328-wizu3arz 47 21 . . . cord-339328-wizu3arz 48 1 Molecular molecular JJ cord-339328-wizu3arz 48 2 imaging imaging NN cord-339328-wizu3arz 48 3 can can MD cord-339328-wizu3arz 48 4 therefore therefore RB cord-339328-wizu3arz 48 5 provide provide VB cord-339328-wizu3arz 48 6 unique unique JJ cord-339328-wizu3arz 48 7 insights insight NNS cord-339328-wizu3arz 48 8 into into IN cord-339328-wizu3arz 48 9 disease disease NN cord-339328-wizu3arz 48 10 pathogenesis pathogenesis NN cord-339328-wizu3arz 48 11 that that WDT cord-339328-wizu3arz 48 12 are be VBP cord-339328-wizu3arz 48 13 not not RB cord-339328-wizu3arz 48 14 possible possible JJ cord-339328-wizu3arz 48 15 with with IN cord-339328-wizu3arz 48 16 traditional traditional JJ cord-339328-wizu3arz 48 17 tools tool NNS cord-339328-wizu3arz 48 18 . . . cord-339328-wizu3arz 49 1 Other other JJ cord-339328-wizu3arz 49 2 applications application NNS cord-339328-wizu3arz 49 3 include include VBP cord-339328-wizu3arz 49 4 assessing assess VBG cord-339328-wizu3arz 49 5 hideouts hideout NNS cord-339328-wizu3arz 49 6 of of IN cord-339328-wizu3arz 49 7 infections infection NNS cord-339328-wizu3arz 49 8 , , , cord-339328-wizu3arz 49 9 defining define VBG cord-339328-wizu3arz 49 10 the the DT cord-339328-wizu3arz 49 11 diversity diversity NN cord-339328-wizu3arz 49 12 of of IN cord-339328-wizu3arz 49 13 the the DT cord-339328-wizu3arz 49 14 microbial microbial JJ cord-339328-wizu3arz 49 15 populations population NNS cord-339328-wizu3arz 49 16 ( ( -LRB- cord-339328-wizu3arz 49 17 microbiome microbiome NNP cord-339328-wizu3arz 49 18 ) ) -RRB- cord-339328-wizu3arz 49 19 , , , cord-339328-wizu3arz 49 20 and and CC cord-339328-wizu3arz 49 21 providing provide VBG cord-339328-wizu3arz 49 22 end end NN cord-339328-wizu3arz 49 23 points point NNS cord-339328-wizu3arz 49 24 to to TO cord-339328-wizu3arz 49 25 assess assess VB cord-339328-wizu3arz 49 26 antimicrobial antimicrobial JJ cord-339328-wizu3arz 49 27 or or CC cord-339328-wizu3arz 49 28 vaccine vaccine NN cord-339328-wizu3arz 49 29 efficacy efficacy NN cord-339328-wizu3arz 49 30 or or CC cord-339328-wizu3arz 49 31 predict predict VB cord-339328-wizu3arz 49 32 stable stable JJ cord-339328-wizu3arz 49 33 cure cure NN cord-339328-wizu3arz 49 34 . . . cord-339328-wizu3arz 50 1 Current current JJ cord-339328-wizu3arz 50 2 antimicrobial antimicrobial JJ cord-339328-wizu3arz 50 3 dosing dose VBG cord-339328-wizu3arz 50 4 regimens regimen NNS cord-339328-wizu3arz 50 5 are be VBP cord-339328-wizu3arz 50 6 based base VBN cord-339328-wizu3arz 50 7 on on IN cord-339328-wizu3arz 50 8 achievable achievable JJ cord-339328-wizu3arz 50 9 serum serum NN cord-339328-wizu3arz 50 10 concentrations concentration NNS cord-339328-wizu3arz 50 11 . . . cord-339328-wizu3arz 51 1 However however RB cord-339328-wizu3arz 51 2 , , , cord-339328-wizu3arz 51 3 a a DT cord-339328-wizu3arz 51 4 growing grow VBG cord-339328-wizu3arz 51 5 number number NN cord-339328-wizu3arz 51 6 of of IN cord-339328-wizu3arz 51 7 studies study NNS cord-339328-wizu3arz 51 8 support support VBP cord-339328-wizu3arz 51 9 the the DT cord-339328-wizu3arz 51 10 importance importance NN cord-339328-wizu3arz 51 11 of of IN cord-339328-wizu3arz 51 12 monitoring monitor VBG cord-339328-wizu3arz 51 13 drug drug NN cord-339328-wizu3arz 51 14 concentration concentration NN cord-339328-wizu3arz 51 15 in in IN cord-339328-wizu3arz 51 16 Table Table NNP cord-339328-wizu3arz 51 17 1 1 CD cord-339328-wizu3arz 51 18 . . . cord-339328-wizu3arz 52 1 Evaluate evaluate VB cord-339328-wizu3arz 52 2 disease disease NN cord-339328-wizu3arz 52 3 processes process VBZ cord-339328-wizu3arz 52 4 deep deep RB cord-339328-wizu3arz 52 5 within within IN cord-339328-wizu3arz 52 6 the the DT cord-339328-wizu3arz 52 7 body body NN cord-339328-wizu3arz 52 8 , , , cord-339328-wizu3arz 52 9 noninvasively noninvasively RB cord-339328-wizu3arz 52 10 , , , cord-339328-wizu3arz 52 11 and and CC cord-339328-wizu3arz 52 12 relatively relatively RB cord-339328-wizu3arz 52 13 rapidly rapidly RB cord-339328-wizu3arz 52 14 Longitudinal longitudinal JJ cord-339328-wizu3arz 52 15 assessments assessment NNS cord-339328-wizu3arz 52 16 in in IN cord-339328-wizu3arz 52 17 the the DT cord-339328-wizu3arz 52 18 same same JJ cord-339328-wizu3arz 52 19 individual individual JJ cord-339328-wizu3arz 52 20 - - HYPH cord-339328-wizu3arz 52 21 fundamental fundamental JJ cord-339328-wizu3arz 52 22 advantage advantage NN cord-339328-wizu3arz 52 23 over over IN cord-339328-wizu3arz 52 24 traditional traditional JJ cord-339328-wizu3arz 52 25 tools tool NNS cord-339328-wizu3arz 52 26 Provide provide VB cord-339328-wizu3arz 52 27 holistic holistic JJ cord-339328-wizu3arz 52 28 , , , cord-339328-wizu3arz 52 29 three three CD cord-339328-wizu3arz 52 30 - - HYPH cord-339328-wizu3arz 52 31 dimensional dimensional JJ cord-339328-wizu3arz 52 32 assessment assessment NN cord-339328-wizu3arz 52 33 of of IN cord-339328-wizu3arz 52 34 the the DT cord-339328-wizu3arz 52 35 whole whole JJ cord-339328-wizu3arz 52 36 organ organ NN cord-339328-wizu3arz 52 37 or or CC cord-339328-wizu3arz 52 38 body body NN cord-339328-wizu3arz 52 39 representative representative NN cord-339328-wizu3arz 52 40 of of IN cord-339328-wizu3arz 52 41 the the DT cord-339328-wizu3arz 52 42 overall overall JJ cord-339328-wizu3arz 52 43 disease disease NN cord-339328-wizu3arz 52 44 ( ( -LRB- cord-339328-wizu3arz 52 45 versus versus IN cord-339328-wizu3arz 52 46 tip tip NN cord-339328-wizu3arz 52 47 of of IN cord-339328-wizu3arz 52 48 a a DT cord-339328-wizu3arz 52 49 biopsy biopsy JJ cord-339328-wizu3arz 52 50 needle needle NN cord-339328-wizu3arz 52 51 ) ) -RRB- cord-339328-wizu3arz 52 52 and and CC cord-339328-wizu3arz 52 53 therefore therefore RB cord-339328-wizu3arz 52 54 less less RBR cord-339328-wizu3arz 52 55 prone prone JJ cord-339328-wizu3arz 52 56 to to IN cord-339328-wizu3arz 52 57 sampling sampling NN cord-339328-wizu3arz 52 58 error error NN cord-339328-wizu3arz 52 59 Imaging Imaging NNP cord-339328-wizu3arz 52 60 in in IN cord-339328-wizu3arz 52 61 infectious infectious JJ cord-339328-wizu3arz 52 62 diseases disease NNS cord-339328-wizu3arz 52 63 Role role NN cord-339328-wizu3arz 52 64 Setting set VBG cord-339328-wizu3arz 52 65 Overall Overall NNP cord-339328-wizu3arz 52 66 goal(s goal(s NNP cord-339328-wizu3arz 52 67 ) ) -RRB- cord-339328-wizu3arz 53 1 Pathogenesis Pathogenesis NNP cord-339328-wizu3arz 53 2 Preclinical Preclinical NNP cord-339328-wizu3arz 53 3 Unique unique JJ cord-339328-wizu3arz 53 4 insights insight NNS cord-339328-wizu3arz 53 5 into into IN cord-339328-wizu3arz 53 6 disease disease NN cord-339328-wizu3arz 53 7 pathogenesis pathogenesis NN cord-339328-wizu3arz 53 8 , , , cord-339328-wizu3arz 53 9 e.g. e.g. RB cord-339328-wizu3arz 53 10 , , , cord-339328-wizu3arz 53 11 assessing assess VBG cord-339328-wizu3arz 53 12 hideouts hideout NNS cord-339328-wizu3arz 53 13 of of IN cord-339328-wizu3arz 53 14 infections infection NNS cord-339328-wizu3arz 53 15 , , , cord-339328-wizu3arz 53 16 defining define VBG cord-339328-wizu3arz 53 17 the the DT cord-339328-wizu3arz 53 18 diversity diversity NN cord-339328-wizu3arz 53 19 of of IN cord-339328-wizu3arz 53 20 the the DT cord-339328-wizu3arz 53 21 microbial microbial JJ cord-339328-wizu3arz 53 22 populations population NNS cord-339328-wizu3arz 53 23 ( ( -LRB- cord-339328-wizu3arz 53 24 microbiome microbiome NN cord-339328-wizu3arz 53 25 ) ) -RRB- cord-339328-wizu3arz 53 26 Studying study VBG cord-339328-wizu3arz 53 27 multi multi JJ cord-339328-wizu3arz 53 28 - - JJ cord-339328-wizu3arz 53 29 compartment compartment JJ cord-339328-wizu3arz 53 30 antimicrobial antimicrobial NN cord-339328-wizu3arz 53 31 pharmacokinetics pharmacokinetic NNS cord-339328-wizu3arz 53 32 Expedite Expedite NNP cord-339328-wizu3arz 53 33 bench bench NN cord-339328-wizu3arz 53 34 - - HYPH cord-339328-wizu3arz 53 35 to to IN cord-339328-wizu3arz 53 36 - - HYPH cord-339328-wizu3arz 53 37 bedside bedside NN cord-339328-wizu3arz 53 38 translation translation NN cord-339328-wizu3arz 53 39 of of IN cord-339328-wizu3arz 53 40 new new JJ cord-339328-wizu3arz 53 41 therapeutics therapeutic NNS cord-339328-wizu3arz 53 42 , , , cord-339328-wizu3arz 53 43 e.g. e.g. RB cord-339328-wizu3arz 53 44 , , , cord-339328-wizu3arz 53 45 surrogate surrogate JJ cord-339328-wizu3arz 53 46 end end NN cord-339328-wizu3arz 53 47 points point NNS cord-339328-wizu3arz 53 48 to to TO cord-339328-wizu3arz 53 49 assess assess VB cord-339328-wizu3arz 53 50 antimicrobial antimicrobial JJ cord-339328-wizu3arz 53 51 or or CC cord-339328-wizu3arz 53 52 vaccine vaccine NN cord-339328-wizu3arz 53 53 efficacy efficacy NN cord-339328-wizu3arz 53 54 or or CC cord-339328-wizu3arz 53 55 predict predict VB cord-339328-wizu3arz 53 56 stable stable JJ cord-339328-wizu3arz 53 57 cure cure NN cord-339328-wizu3arz 53 58 Clinical clinical JJ cord-339328-wizu3arz 53 59 trials trial NNS cord-339328-wizu3arz 54 1 Unique unique JJ cord-339328-wizu3arz 54 2 insights insight NNS cord-339328-wizu3arz 54 3 into into IN cord-339328-wizu3arz 54 4 disease disease NN cord-339328-wizu3arz 54 5 pathogenesis pathogenesis NN cord-339328-wizu3arz 54 6 - - HYPH cord-339328-wizu3arz 54 7 noninvasive noninvasive JJ cord-339328-wizu3arz 54 8 visualization visualization NN cord-339328-wizu3arz 54 9 of of IN cord-339328-wizu3arz 54 10 processes process NNS cord-339328-wizu3arz 54 11 deep deep RB cord-339328-wizu3arz 54 12 inside inside IN cord-339328-wizu3arz 54 13 the the DT cord-339328-wizu3arz 54 14 body body NN cord-339328-wizu3arz 54 15 Phase phase NN cord-339328-wizu3arz 54 16 0 0 CD cord-339328-wizu3arz 54 17 studies study NNS cord-339328-wizu3arz 54 18 to to TO cord-339328-wizu3arz 54 19 determine determine VB cord-339328-wizu3arz 54 20 compartment compartment NN cord-339328-wizu3arz 54 21 - - HYPH cord-339328-wizu3arz 54 22 specific specific JJ cord-339328-wizu3arz 54 23 antimicrobial antimicrobial JJ cord-339328-wizu3arz 54 24 penetration penetration NN cord-339328-wizu3arz 54 25 / / SYM cord-339328-wizu3arz 54 26 binding binding NN cord-339328-wizu3arz 54 27 ( ( -LRB- cord-339328-wizu3arz 54 28 sites site NNS cord-339328-wizu3arz 54 29 of of IN cord-339328-wizu3arz 54 30 infection infection NN cord-339328-wizu3arz 54 31 , , , cord-339328-wizu3arz 54 32 necrotic necrotic JJ cord-339328-wizu3arz 54 33 / / SYM cord-339328-wizu3arz 54 34 fibrotic fibrotic JJ cord-339328-wizu3arz 54 35 lesions lesion NNS cord-339328-wizu3arz 54 36 , , , cord-339328-wizu3arz 54 37 privileged privileged JJ cord-339328-wizu3arz 54 38 sites site NNS cord-339328-wizu3arz 54 39 - - : cord-339328-wizu3arz 54 40 CNS CNS NNP cord-339328-wizu3arz 54 41 ) ) -RRB- cord-339328-wizu3arz 54 42 to to TO cord-339328-wizu3arz 54 43 inform inform VB cord-339328-wizu3arz 54 44 appropriate appropriate JJ cord-339328-wizu3arz 54 45 dosing dosing NN cord-339328-wizu3arz 54 46 of of IN cord-339328-wizu3arz 54 47 novel novel JJ cord-339328-wizu3arz 54 48 drugs drug NNS cord-339328-wizu3arz 54 49 ; ; : cord-339328-wizu3arz 54 50 determine determine VB cord-339328-wizu3arz 54 51 accumulation accumulation NN cord-339328-wizu3arz 54 52 at at IN cord-339328-wizu3arz 54 53 non non JJ cord-339328-wizu3arz 54 54 - - JJ cord-339328-wizu3arz 54 55 target target JJ cord-339328-wizu3arz 54 56 sites site NNS cord-339328-wizu3arz 54 57 to to TO cord-339328-wizu3arz 54 58 assess assess VB cord-339328-wizu3arz 54 59 potential potential JJ cord-339328-wizu3arz 54 60 toxicities toxicity NNS cord-339328-wizu3arz 54 61 ; ; : cord-339328-wizu3arz 54 62 current current JJ cord-339328-wizu3arz 54 63 US US NNP cord-339328-wizu3arz 54 64 Food Food NNP cord-339328-wizu3arz 54 65 and and CC cord-339328-wizu3arz 54 66 Drug Drug NNP cord-339328-wizu3arz 54 67 Administration Administration NNP cord-339328-wizu3arz 54 68 ( ( -LRB- cord-339328-wizu3arz 54 69 FDA FDA NNP cord-339328-wizu3arz 54 70 ) ) -RRB- cord-339328-wizu3arz 54 71 guidelines guideline NNS cord-339328-wizu3arz 54 72 require require VBP cord-339328-wizu3arz 54 73 tissue tissue NN cord-339328-wizu3arz 54 74 drug drug NN cord-339328-wizu3arz 54 75 distribution distribution NN cord-339328-wizu3arz 54 76 studies study NNS cord-339328-wizu3arz 54 77 at at IN cord-339328-wizu3arz 54 78 the the DT cord-339328-wizu3arz 54 79 infected infect VBN cord-339328-wizu3arz 54 80 sites site NNS cord-339328-wizu3arz 54 81 Patient patient NN cord-339328-wizu3arz 54 82 settings setting NNS cord-339328-wizu3arz 54 83 Enabling enable VBG cord-339328-wizu3arz 54 84 precision precision NN cord-339328-wizu3arz 54 85 medicine medicine NN cord-339328-wizu3arz 54 86 by by IN cord-339328-wizu3arz 54 87 providing provide VBG cord-339328-wizu3arz 54 88 unique unique JJ cord-339328-wizu3arz 54 89 insights insight NNS cord-339328-wizu3arz 54 90 into into IN cord-339328-wizu3arz 54 91 disease disease NN cord-339328-wizu3arz 54 92 pathogenesis pathogenesis NN cord-339328-wizu3arz 54 93 , , , cord-339328-wizu3arz 54 94 antimicrobial antimicrobial JJ cord-339328-wizu3arz 54 95 pharmacokinetics pharmacokinetic NNS cord-339328-wizu3arz 54 96 , , , cord-339328-wizu3arz 54 97 etc etc FW cord-339328-wizu3arz 54 98 . . . cord-339328-wizu3arz 55 1 Clinical clinical JJ cord-339328-wizu3arz 55 2 trials trial NNS cord-339328-wizu3arz 55 3 and and CC cord-339328-wizu3arz 55 4 patient patient NN cord-339328-wizu3arz 55 5 settings setting NNS cord-339328-wizu3arz 55 6 Rapidly rapidly RB cord-339328-wizu3arz 55 7 and and CC cord-339328-wizu3arz 55 8 specifically specifically RB cord-339328-wizu3arz 55 9 distinguish distinguish VB cord-339328-wizu3arz 55 10 an an DT cord-339328-wizu3arz 55 11 infectious infectious JJ cord-339328-wizu3arz 55 12 process process NN cord-339328-wizu3arz 55 13 from from IN cord-339328-wizu3arz 55 14 other other JJ cord-339328-wizu3arz 55 15 diseases disease NNS cord-339328-wizu3arz 55 16 ( ( -LRB- cord-339328-wizu3arz 55 17 malignancy malignancy NN cord-339328-wizu3arz 55 18 , , , cord-339328-wizu3arz 55 19 sterile sterile JJ cord-339328-wizu3arz 55 20 inflammatory inflammatory JJ cord-339328-wizu3arz 55 21 processes process NNS cord-339328-wizu3arz 55 22 , , , cord-339328-wizu3arz 55 23 etc etc FW cord-339328-wizu3arz 55 24 . . . cord-339328-wizu3arz 55 25 ) ) -RRB- cord-339328-wizu3arz 56 1 Determine determine VB cord-339328-wizu3arz 56 2 the the DT cord-339328-wizu3arz 56 3 site site NN cord-339328-wizu3arz 56 4 ( ( -LRB- cord-339328-wizu3arz 56 5 e.g. e.g. RB cord-339328-wizu3arz 56 6 , , , cord-339328-wizu3arz 56 7 extension extension NN cord-339328-wizu3arz 56 8 / / SYM cord-339328-wizu3arz 56 9 metastasis metastasis NN cord-339328-wizu3arz 56 10 to to IN cord-339328-wizu3arz 56 11 other other JJ cord-339328-wizu3arz 56 12 organs organ NNS cord-339328-wizu3arz 56 13 or or CC cord-339328-wizu3arz 56 14 privileged privileged JJ cord-339328-wizu3arz 56 15 sites site NNS cord-339328-wizu3arz 56 16 ) ) -RRB- cord-339328-wizu3arz 56 17 and and CC cord-339328-wizu3arz 56 18 extent extent NN cord-339328-wizu3arz 56 19 of of IN cord-339328-wizu3arz 56 20 disease disease NN cord-339328-wizu3arz 56 21 Provide provide VB cord-339328-wizu3arz 56 22 information information NN cord-339328-wizu3arz 56 23 on on IN cord-339328-wizu3arz 56 24 the the DT cord-339328-wizu3arz 56 25 class class NN cord-339328-wizu3arz 56 26 of of IN cord-339328-wizu3arz 56 27 the the DT cord-339328-wizu3arz 56 28 infectious infectious JJ cord-339328-wizu3arz 56 29 pathogen pathogen NN cord-339328-wizu3arz 56 30 , , , cord-339328-wizu3arz 56 31 which which WDT cord-339328-wizu3arz 56 32 could could MD cord-339328-wizu3arz 56 33 help help VB cord-339328-wizu3arz 56 34 in in IN cord-339328-wizu3arz 56 35 targeted target VBN cord-339328-wizu3arz 56 36 empiric empiric JJ cord-339328-wizu3arz 56 37 antimicrobial antimicrobial JJ cord-339328-wizu3arz 56 38 treatments treatment NNS cord-339328-wizu3arz 56 39 Monitoring monitoring NN cord-339328-wizu3arz 56 40 and and CC cord-339328-wizu3arz 56 41 prognostication prognostication NN cord-339328-wizu3arz 56 42 Preclinical Preclinical NNP cord-339328-wizu3arz 56 43 Noninvasive noninvasive JJ cord-339328-wizu3arz 56 44 longitudinal longitudinal JJ cord-339328-wizu3arz 56 45 assessments assessment NNS cord-339328-wizu3arz 56 46 , , , cord-339328-wizu3arz 56 47 especially especially RB cord-339328-wizu3arz 56 48 in in IN cord-339328-wizu3arz 56 49 studies study NNS cord-339328-wizu3arz 56 50 utilizing utilize VBG cord-339328-wizu3arz 56 51 larger large JJR cord-339328-wizu3arz 56 52 , , , cord-339328-wizu3arz 56 53 more more RBR cord-339328-wizu3arz 56 54 expensive expensive JJ cord-339328-wizu3arz 56 55 animal animal NN cord-339328-wizu3arz 56 56 species specie NNS cord-339328-wizu3arz 56 57 ; ; , cord-339328-wizu3arz 56 58 serial serial JJ cord-339328-wizu3arz 56 59 assessments assessment NNS cord-339328-wizu3arz 56 60 in in IN cord-339328-wizu3arz 56 61 the the DT cord-339328-wizu3arz 56 62 same same JJ cord-339328-wizu3arz 56 63 animal animal NN cord-339328-wizu3arz 56 64 could could MD cord-339328-wizu3arz 56 65 significantly significantly RB cord-339328-wizu3arz 56 66 reduce reduce VB cord-339328-wizu3arz 56 67 sample sample NN cord-339328-wizu3arz 56 68 size size NN cord-339328-wizu3arz 56 69 , , , cord-339328-wizu3arz 56 70 inter inter JJ cord-339328-wizu3arz 56 71 - - JJ cord-339328-wizu3arz 56 72 animal animal JJ cord-339328-wizu3arz 56 73 variability variability NN cord-339328-wizu3arz 56 74 ( ( -LRB- cord-339328-wizu3arz 56 75 outbreed outbreed NN cord-339328-wizu3arz 56 76 animals animal NNS cord-339328-wizu3arz 56 77 ) ) -RRB- cord-339328-wizu3arz 56 78 , , , cord-339328-wizu3arz 56 79 and and CC cord-339328-wizu3arz 56 80 therefore therefore RB cord-339328-wizu3arz 56 81 cost cost VBP cord-339328-wizu3arz 56 82 of of IN cord-339328-wizu3arz 56 83 the the DT cord-339328-wizu3arz 56 84 studies study NNS cord-339328-wizu3arz 56 85 Clinical clinical JJ cord-339328-wizu3arz 56 86 trials trial NNS cord-339328-wizu3arz 56 87 Early early RB cord-339328-wizu3arz 56 88 end end NN cord-339328-wizu3arz 56 89 points point NNS cord-339328-wizu3arz 56 90 for for IN cord-339328-wizu3arz 56 91 treatment treatment NN cord-339328-wizu3arz 56 92 trials trial NNS cord-339328-wizu3arz 56 93 to to TO cord-339328-wizu3arz 56 94 assess assess VB cord-339328-wizu3arz 56 95 activity activity NN cord-339328-wizu3arz 56 96 of of IN cord-339328-wizu3arz 56 97 treatments treatment NNS cord-339328-wizu3arz 56 98 and and CC cord-339328-wizu3arz 56 99 to to TO cord-339328-wizu3arz 56 100 predict predict VB cord-339328-wizu3arz 56 101 stable stable JJ cord-339328-wizu3arz 56 102 cure cure NN cord-339328-wizu3arz 57 1 Assessing assess VBG cord-339328-wizu3arz 57 2 host host NN cord-339328-wizu3arz 57 3 - - HYPH cord-339328-wizu3arz 57 4 directed direct VBN cord-339328-wizu3arz 57 5 treatments treatment NNS cord-339328-wizu3arz 57 6 for for IN cord-339328-wizu3arz 57 7 infections infection NNS cord-339328-wizu3arz 57 8 Enable enable VBP cord-339328-wizu3arz 57 9 adaptive adaptive JJ cord-339328-wizu3arz 57 10 designs design NNS cord-339328-wizu3arz 57 11 Patient patient JJ cord-339328-wizu3arz 57 12 settings setting NNS cord-339328-wizu3arz 57 13 Rapidly rapidly RB cord-339328-wizu3arz 57 14 detect detect VBP cord-339328-wizu3arz 57 15 treatment treatment NN cord-339328-wizu3arz 57 16 failures failure NNS cord-339328-wizu3arz 57 17 due due JJ cord-339328-wizu3arz 57 18 to to IN cord-339328-wizu3arz 57 19 drug drug NN cord-339328-wizu3arz 57 20 - - HYPH cord-339328-wizu3arz 57 21 resistant resistant JJ cord-339328-wizu3arz 57 22 organisms organism NNS cord-339328-wizu3arz 57 23 or or CC cord-339328-wizu3arz 57 24 other other JJ cord-339328-wizu3arz 57 25 reasons reason NNS cord-339328-wizu3arz 58 1 Rapidly rapidly RB cord-339328-wizu3arz 58 2 monitor monitor VB cord-339328-wizu3arz 58 3 treatment treatment NN cord-339328-wizu3arz 58 4 responses response NNS cord-339328-wizu3arz 58 5 in in IN cord-339328-wizu3arz 58 6 patients patient NNS cord-339328-wizu3arz 58 7 with with IN cord-339328-wizu3arz 58 8 drug drug NN cord-339328-wizu3arz 58 9 - - HYPH cord-339328-wizu3arz 58 10 resistant resistant JJ cord-339328-wizu3arz 58 11 organisms organism NNS cord-339328-wizu3arz 58 12 and and CC cord-339328-wizu3arz 58 13 individualize individualize VB cord-339328-wizu3arz 58 14 treatments treatment NNS cord-339328-wizu3arz 58 15 Early early RB cord-339328-wizu3arz 58 16 end end NN cord-339328-wizu3arz 58 17 points point NNS cord-339328-wizu3arz 58 18 for for IN cord-339328-wizu3arz 58 19 duration duration NN cord-339328-wizu3arz 58 20 of of IN cord-339328-wizu3arz 58 21 treatment treatment NN cord-339328-wizu3arz 58 22 and and CC cord-339328-wizu3arz 58 23 predict predict VB cord-339328-wizu3arz 58 24 stable stable JJ cord-339328-wizu3arz 58 25 cure cure NN cord-339328-wizu3arz 58 26 enabling enable VBG cord-339328-wizu3arz 58 27 precision precision NN cord-339328-wizu3arz 58 28 medicine medicine NN cord-339328-wizu3arz 58 29 Public Public NNP cord-339328-wizu3arz 58 30 health health NN cord-339328-wizu3arz 58 31 Rapid Rapid NNP cord-339328-wizu3arz 58 32 determination determination NN cord-339328-wizu3arz 58 33 of of IN cord-339328-wizu3arz 58 34 the the DT cord-339328-wizu3arz 58 35 infectious infectious JJ cord-339328-wizu3arz 58 36 risk risk NN cord-339328-wizu3arz 58 37 of of IN cord-339328-wizu3arz 58 38 a a DT cord-339328-wizu3arz 58 39 patient patient NN cord-339328-wizu3arz 58 40 to to IN cord-339328-wizu3arz 58 41 the the DT cord-339328-wizu3arz 58 42 population population NN cord-339328-wizu3arz 58 43 based base VBN cord-339328-wizu3arz 58 44 on on IN cord-339328-wizu3arz 58 45 response response NN cord-339328-wizu3arz 58 46 to to IN cord-339328-wizu3arz 58 47 treatment treatment NN cord-339328-wizu3arz 58 48 and and CC cord-339328-wizu3arz 58 49 extent extent NN cord-339328-wizu3arz 58 50 and and CC cord-339328-wizu3arz 58 51 location location NN cord-339328-wizu3arz 58 52 of of IN cord-339328-wizu3arz 58 53 disease disease NN cord-339328-wizu3arz 58 54 Rapid Rapid NNP cord-339328-wizu3arz 58 55 diagnosis diagnosis NN cord-339328-wizu3arz 58 56 and and CC cord-339328-wizu3arz 58 57 monitoring monitoring NN cord-339328-wizu3arz 58 58 of of IN cord-339328-wizu3arz 58 59 biothreat biothreat NNP cord-339328-wizu3arz 58 60 agents agent NNS cord-339328-wizu3arz 58 61 infected infect VBD cord-339328-wizu3arz 58 62 tissues tissue NNS cord-339328-wizu3arz 58 63 , , , cord-339328-wizu3arz 58 64 rather rather RB cord-339328-wizu3arz 58 65 than than IN cord-339328-wizu3arz 58 66 serum serum NN cord-339328-wizu3arz 58 67 alone alone RB cord-339328-wizu3arz 58 68 . . . cord-339328-wizu3arz 59 1 Inadequate inadequate JJ cord-339328-wizu3arz 59 2 drug drug NN cord-339328-wizu3arz 59 3 concentrations concentration NNS cord-339328-wizu3arz 59 4 in in IN cord-339328-wizu3arz 59 5 target target NN cord-339328-wizu3arz 59 6 tissues tissue NNS cord-339328-wizu3arz 59 7 can can MD cord-339328-wizu3arz 59 8 lead lead VB cord-339328-wizu3arz 59 9 to to IN cord-339328-wizu3arz 59 10 treatment treatment NN cord-339328-wizu3arz 59 11 failure failure NN cord-339328-wizu3arz 59 12 and and CC cord-339328-wizu3arz 59 13 selection selection NN cord-339328-wizu3arz 59 14 of of IN cord-339328-wizu3arz 59 15 drug drug NN cord-339328-wizu3arz 59 16 - - HYPH cord-339328-wizu3arz 59 17 resistant resistant JJ cord-339328-wizu3arz 59 18 organisms organism NNS cord-339328-wizu3arz 59 19 . . . cord-339328-wizu3arz 60 1 Additionally additionally RB cord-339328-wizu3arz 60 2 , , , cord-339328-wizu3arz 60 3 altered alter VBN cord-339328-wizu3arz 60 4 metabolism metabolism NN cord-339328-wizu3arz 60 5 in in IN cord-339328-wizu3arz 60 6 diseased diseased JJ cord-339328-wizu3arz 60 7 states state NNS cord-339328-wizu3arz 60 8 may may MD cord-339328-wizu3arz 60 9 lead lead VB cord-339328-wizu3arz 60 10 to to IN cord-339328-wizu3arz 60 11 organ organ NN cord-339328-wizu3arz 60 12 toxicities toxicity NNS cord-339328-wizu3arz 60 13 . . . cord-339328-wizu3arz 61 1 Vancomycin Vancomycin NNP cord-339328-wizu3arz 61 2 , , , cord-339328-wizu3arz 61 3 a a DT cord-339328-wizu3arz 61 4 widely widely RB cord-339328-wizu3arz 61 5 used use VBN cord-339328-wizu3arz 61 6 antimicrobial antimicrobial NN cord-339328-wizu3arz 61 7 to to TO cord-339328-wizu3arz 61 8 treat treat VB cord-339328-wizu3arz 61 9 drug drug NN cord-339328-wizu3arz 61 10 - - HYPH cord-339328-wizu3arz 61 11 resistant resistant JJ cord-339328-wizu3arz 61 12 , , , cord-339328-wizu3arz 61 13 Gram gram NN cord-339328-wizu3arz 61 14 - - HYPH cord-339328-wizu3arz 61 15 positive positive JJ cord-339328-wizu3arz 61 16 bacteria bacteria NNS cord-339328-wizu3arz 61 17 , , , cord-339328-wizu3arz 61 18 highlights highlight VBZ cord-339328-wizu3arz 61 19 these these DT cord-339328-wizu3arz 61 20 limitations limitation NNS cord-339328-wizu3arz 61 21 . . . cord-339328-wizu3arz 62 1 Studies study NNS cord-339328-wizu3arz 62 2 performed perform VBN cord-339328-wizu3arz 62 3 in in IN cord-339328-wizu3arz 62 4 response response NN cord-339328-wizu3arz 62 5 to to IN cord-339328-wizu3arz 62 6 treatment treatment NN cord-339328-wizu3arz 62 7 failures failure NNS cord-339328-wizu3arz 62 8 noted note VBN cord-339328-wizu3arz 62 9 in in IN cord-339328-wizu3arz 62 10 patients patient NNS cord-339328-wizu3arz 62 11 with with IN cord-339328-wizu3arz 62 12 standard standard JJ cord-339328-wizu3arz 62 13 doses dose NNS cord-339328-wizu3arz 62 14 of of IN cord-339328-wizu3arz 62 15 vancomycin vancomycin NNS cord-339328-wizu3arz 62 16 revealed reveal VBD cord-339328-wizu3arz 62 17 that that IN cord-339328-wizu3arz 62 18 it -PRON- PRP cord-339328-wizu3arz 62 19 penetrates penetrate VBZ cord-339328-wizu3arz 62 20 poorly poorly RB cord-339328-wizu3arz 62 21 into into IN cord-339328-wizu3arz 62 22 infected infected JJ cord-339328-wizu3arz 62 23 tissues tissue NNS cord-339328-wizu3arz 62 24 , , , cord-339328-wizu3arz 62 25 with with IN cord-339328-wizu3arz 62 26 levels level NNS cord-339328-wizu3arz 62 27 only only RB cord-339328-wizu3arz 62 28 one one CD cord-339328-wizu3arz 62 29 sixth sixth NN cord-339328-wizu3arz 62 30 of of IN cord-339328-wizu3arz 62 31 plasma plasma NN cord-339328-wizu3arz 62 32 [ [ -LRB- cord-339328-wizu3arz 62 33 21 21 CD cord-339328-wizu3arz 62 34 ] ] -RRB- cord-339328-wizu3arz 62 35 . . . cord-339328-wizu3arz 63 1 Conversely conversely RB cord-339328-wizu3arz 63 2 , , , cord-339328-wizu3arz 63 3 high high JJ cord-339328-wizu3arz 63 4 levels level NNS cord-339328-wizu3arz 63 5 of of IN cord-339328-wizu3arz 63 6 vancomycin vancomycin NN cord-339328-wizu3arz 63 7 can can MD cord-339328-wizu3arz 63 8 cause cause VB cord-339328-wizu3arz 63 9 nephrotoxicity nephrotoxicity NNP cord-339328-wizu3arz 63 10 . . . cord-339328-wizu3arz 64 1 Based base VBN cord-339328-wizu3arz 64 2 on on IN cord-339328-wizu3arz 64 3 these these DT cord-339328-wizu3arz 64 4 data datum NNS cord-339328-wizu3arz 64 5 , , , cord-339328-wizu3arz 64 6 new new JJ cord-339328-wizu3arz 64 7 recommendations recommendation NNS cord-339328-wizu3arz 64 8 have have VBP cord-339328-wizu3arz 64 9 been be VBN cord-339328-wizu3arz 64 10 developed develop VBN cord-339328-wizu3arz 64 11 for for IN cord-339328-wizu3arz 64 12 vancomycin vancomycin NN cord-339328-wizu3arz 64 13 [ [ -LRB- cord-339328-wizu3arz 64 14 22 22 CD cord-339328-wizu3arz 64 15 ] ] -RRB- cord-339328-wizu3arz 64 16 , , , cord-339328-wizu3arz 64 17 which which WDT cord-339328-wizu3arz 64 18 , , , cord-339328-wizu3arz 64 19 unfortunately unfortunately RB cord-339328-wizu3arz 64 20 , , , cord-339328-wizu3arz 64 21 had have VBD cord-339328-wizu3arz 64 22 been be VBN cord-339328-wizu3arz 64 23 inappropriately inappropriately RB cord-339328-wizu3arz 64 24 under under RB cord-339328-wizu3arz 64 25 - - HYPH cord-339328-wizu3arz 64 26 dosed dose VBN cord-339328-wizu3arz 64 27 for for IN cord-339328-wizu3arz 64 28 decades decade NNS cord-339328-wizu3arz 64 29 . . . cord-339328-wizu3arz 65 1 Noninvasive noninvasive JJ cord-339328-wizu3arz 65 2 bioimaging bioimaging NN cord-339328-wizu3arz 65 3 can can MD cord-339328-wizu3arz 65 4 be be VB cord-339328-wizu3arz 65 5 used use VBN cord-339328-wizu3arz 65 6 to to TO cord-339328-wizu3arz 65 7 assess assess VB cord-339328-wizu3arz 65 8 the the DT cord-339328-wizu3arz 65 9 distribution distribution NN cord-339328-wizu3arz 65 10 of of IN cord-339328-wizu3arz 65 11 drugs drug NNS cord-339328-wizu3arz 65 12 into into IN cord-339328-wizu3arz 65 13 multiple multiple JJ cord-339328-wizu3arz 65 14 compartments compartment NNS cord-339328-wizu3arz 65 15 of of IN cord-339328-wizu3arz 65 16 interest interest NN cord-339328-wizu3arz 65 17 , , , cord-339328-wizu3arz 65 18 simultaneously simultaneously RB cord-339328-wizu3arz 65 19 . . . cord-339328-wizu3arz 66 1 For for IN cord-339328-wizu3arz 66 2 example example NN cord-339328-wizu3arz 66 3 , , , cord-339328-wizu3arz 66 4 given give VBN cord-339328-wizu3arz 66 5 the the DT cord-339328-wizu3arz 66 6 importance importance NN cord-339328-wizu3arz 66 7 of of IN cord-339328-wizu3arz 66 8 rifampin rifampin NN cord-339328-wizu3arz 66 9 for for IN cord-339328-wizu3arz 66 10 successful successful JJ cord-339328-wizu3arz 66 11 cure cure NN cord-339328-wizu3arz 66 12 , , , cord-339328-wizu3arz 66 13 potential potential NN cord-339328-wizu3arz 66 14 for for IN cord-339328-wizu3arz 66 15 shortening shorten VBG cord-339328-wizu3arz 66 16 the the DT cord-339328-wizu3arz 66 17 duration duration NN cord-339328-wizu3arz 66 18 of of IN cord-339328-wizu3arz 66 19 TB TB NNP cord-339328-wizu3arz 66 20 treatments treatment NNS cord-339328-wizu3arz 66 21 , , , cord-339328-wizu3arz 66 22 and and CC cord-339328-wizu3arz 66 23 the the DT cord-339328-wizu3arz 66 24 limited limited JJ cord-339328-wizu3arz 66 25 availability availability NN cord-339328-wizu3arz 66 26 of of IN cord-339328-wizu3arz 66 27 in in IN cord-339328-wizu3arz 66 28 situ situ JJ cord-339328-wizu3arz 66 29 data datum NNS cord-339328-wizu3arz 66 30 [ [ -LRB- cord-339328-wizu3arz 66 31 23 23 CD cord-339328-wizu3arz 66 32 ] ] -RRB- cord-339328-wizu3arz 66 33 , , , cord-339328-wizu3arz 66 34 dynamic dynamic JJ cord-339328-wizu3arz 66 35 PET pet NN cord-339328-wizu3arz 66 36 imaging imaging NN cord-339328-wizu3arz 66 37 was be VBD cord-339328-wizu3arz 66 38 performed perform VBN cord-339328-wizu3arz 66 39 over over IN cord-339328-wizu3arz 66 40 60 60 CD cord-339328-wizu3arz 66 41 min min NN cord-339328-wizu3arz 66 42 after after IN cord-339328-wizu3arz 66 43 injection injection NN cord-339328-wizu3arz 66 44 of of IN cord-339328-wizu3arz 66 45 11 11 CD cord-339328-wizu3arz 66 46 C c NN cord-339328-wizu3arz 66 47 - - , cord-339328-wizu3arz 66 48 rifampin rifampin NN cord-339328-wizu3arz 66 49 in in IN cord-339328-wizu3arz 66 50 live live NN cord-339328-wizu3arz 66 51 , , , cord-339328-wizu3arz 66 52 M. M. NNP cord-339328-wizu3arz 66 53 tuberculosis tuberculosis NN cord-339328-wizu3arz 66 54 - - HYPH cord-339328-wizu3arz 66 55 infected infect VBN cord-339328-wizu3arz 66 56 mice mouse NNS cord-339328-wizu3arz 66 57 [ [ -LRB- cord-339328-wizu3arz 66 58 24 24 CD cord-339328-wizu3arz 66 59 ] ] -RRB- cord-339328-wizu3arz 66 60 . . . cord-339328-wizu3arz 67 1 11 11 CD cord-339328-wizu3arz 67 2 C c NN cord-339328-wizu3arz 67 3 - - , cord-339328-wizu3arz 67 4 rifampin rifampin NNP cord-339328-wizu3arz 67 5 rapidly rapidly RB cord-339328-wizu3arz 67 6 distributed distribute VBD cord-339328-wizu3arz 67 7 and and CC cord-339328-wizu3arz 67 8 quickly quickly RB cord-339328-wizu3arz 67 9 localized localized JJ cord-339328-wizu3arz 67 10 to to IN cord-339328-wizu3arz 67 11 the the DT cord-339328-wizu3arz 67 12 liver liver NN cord-339328-wizu3arz 67 13 . . . cord-339328-wizu3arz 68 1 Areas area NNS cord-339328-wizu3arz 68 2 under under IN cord-339328-wizu3arz 68 3 the the DT cord-339328-wizu3arz 68 4 concentration concentration NN cord-339328-wizu3arz 68 5 - - HYPH cord-339328-wizu3arz 68 6 time time NN cord-339328-wizu3arz 68 7 curve curve NN cord-339328-wizu3arz 68 8 for for IN cord-339328-wizu3arz 68 9 the the DT cord-339328-wizu3arz 68 10 first first JJ cord-339328-wizu3arz 68 11 60 60 CD cord-339328-wizu3arz 68 12 min min NN cord-339328-wizu3arz 68 13 ( ( -LRB- cord-339328-wizu3arz 68 14 AUC AUC NNP cord-339328-wizu3arz 68 15 0 0 CD cord-339328-wizu3arz 68 16 - - SYM cord-339328-wizu3arz 68 17 60 60 CD cord-339328-wizu3arz 68 18 ) ) -RRB- cord-339328-wizu3arz 68 19 in in IN cord-339328-wizu3arz 68 20 infected infected JJ cord-339328-wizu3arz 68 21 and and CC cord-339328-wizu3arz 68 22 uninfected uninfected JJ cord-339328-wizu3arz 68 23 mice mouse NNS cord-339328-wizu3arz 68 24 were be VBD cord-339328-wizu3arz 68 25 uniformly uniformly RB cord-339328-wizu3arz 68 26 low low JJ cord-339328-wizu3arz 68 27 in in IN cord-339328-wizu3arz 68 28 the the DT cord-339328-wizu3arz 68 29 brain brain NN cord-339328-wizu3arz 68 30 ( ( -LRB- cord-339328-wizu3arz 68 31 10 10 CD cord-339328-wizu3arz 68 32 to to TO cord-339328-wizu3arz 68 33 20 20 CD cord-339328-wizu3arz 68 34 % % NN cord-339328-wizu3arz 68 35 of of IN cord-339328-wizu3arz 68 36 blood blood NN cord-339328-wizu3arz 68 37 values value NNS cord-339328-wizu3arz 68 38 ) ) -RRB- cord-339328-wizu3arz 68 39 . . . cord-339328-wizu3arz 69 1 However however RB cord-339328-wizu3arz 69 2 , , , cord-339328-wizu3arz 69 3 lower low JJR cord-339328-wizu3arz 69 4 concentrations concentration NNS cord-339328-wizu3arz 69 5 were be VBD cord-339328-wizu3arz 69 6 noted note VBN cord-339328-wizu3arz 69 7 in in IN cord-339328-wizu3arz 69 8 necrotic necrotic JJ cord-339328-wizu3arz 69 9 lung lung NN cord-339328-wizu3arz 69 10 tissues tissue NNS cord-339328-wizu3arz 69 11 of of IN cord-339328-wizu3arz 69 12 infected infected JJ cord-339328-wizu3arz 69 13 mice mouse NNS cord-339328-wizu3arz 69 14 than than IN cord-339328-wizu3arz 69 15 in in IN cord-339328-wizu3arz 69 16 healthy healthy JJ cord-339328-wizu3arz 69 17 lungs lung NNS cord-339328-wizu3arz 69 18 , , , cord-339328-wizu3arz 69 19 demonstrating demonstrate VBG cord-339328-wizu3arz 69 20 the the DT cord-339328-wizu3arz 69 21 need need NN cord-339328-wizu3arz 69 22 for for IN cord-339328-wizu3arz 69 23 higher high JJR cord-339328-wizu3arz 69 24 dosing dosing NN cord-339328-wizu3arz 69 25 than than IN cord-339328-wizu3arz 69 26 those those DT cord-339328-wizu3arz 69 27 determined determine VBN cord-339328-wizu3arz 69 28 by by IN cord-339328-wizu3arz 69 29 serum serum NN cord-339328-wizu3arz 69 30 levels level NNS cord-339328-wizu3arz 69 31 alone alone RB cord-339328-wizu3arz 69 32 . . . cord-339328-wizu3arz 70 1 An an DT cord-339328-wizu3arz 70 2 ideal ideal JJ cord-339328-wizu3arz 70 3 imaging imaging NN cord-339328-wizu3arz 70 4 agent agent NN cord-339328-wizu3arz 70 5 for for IN cord-339328-wizu3arz 70 6 diagnosing diagnose VBG cord-339328-wizu3arz 70 7 infections infection NNS cord-339328-wizu3arz 70 8 needs need VBZ cord-339328-wizu3arz 70 9 to to TO cord-339328-wizu3arz 70 10 be be VB cord-339328-wizu3arz 70 11 both both CC cord-339328-wizu3arz 70 12 sensitive sensitive JJ cord-339328-wizu3arz 70 13 and and CC cord-339328-wizu3arz 70 14 specific specific JJ cord-339328-wizu3arz 70 15 . . . cord-339328-wizu3arz 71 1 While while IN cord-339328-wizu3arz 71 2 current current JJ cord-339328-wizu3arz 71 3 , , , cord-339328-wizu3arz 71 4 noninvasive noninvasive JJ cord-339328-wizu3arz 71 5 techniques technique NNS cord-339328-wizu3arz 71 6 , , , cord-339328-wizu3arz 71 7 such such JJ cord-339328-wizu3arz 71 8 as as IN cord-339328-wizu3arz 71 9 CT CT NNP cord-339328-wizu3arz 71 10 , , , cord-339328-wizu3arz 71 11 magnetic magnetic JJ cord-339328-wizu3arz 71 12 resonance resonance NN cord-339328-wizu3arz 71 13 imaging imaging NN cord-339328-wizu3arz 71 14 ( ( -LRB- cord-339328-wizu3arz 71 15 MRI MRI NNP cord-339328-wizu3arz 71 16 ) ) -RRB- cord-339328-wizu3arz 71 17 , , , cord-339328-wizu3arz 71 18 and and CC cord-339328-wizu3arz 71 19 ultrasound ultrasound NN cord-339328-wizu3arz 71 20 , , , cord-339328-wizu3arz 71 21 can can MD cord-339328-wizu3arz 71 22 rapidly rapidly RB cord-339328-wizu3arz 71 23 detect detect VB cord-339328-wizu3arz 71 24 anatomic anatomic JJ cord-339328-wizu3arz 71 25 pathology pathology NN cord-339328-wizu3arz 71 26 , , , cord-339328-wizu3arz 71 27 they -PRON- PRP cord-339328-wizu3arz 71 28 are be VBP cord-339328-wizu3arz 71 29 non non JJ cord-339328-wizu3arz 71 30 - - JJ cord-339328-wizu3arz 71 31 specific specific JJ cord-339328-wizu3arz 71 32 and and CC cord-339328-wizu3arz 71 33 can can MD cord-339328-wizu3arz 71 34 not not RB cord-339328-wizu3arz 71 35 reliably reliably RB cord-339328-wizu3arz 71 36 differentiate differentiate VB cord-339328-wizu3arz 71 37 infectious infectious JJ cord-339328-wizu3arz 71 38 lesions lesion NNS cord-339328-wizu3arz 71 39 from from IN cord-339328-wizu3arz 71 40 non non JJ cord-339328-wizu3arz 71 41 - - JJ cord-339328-wizu3arz 71 42 infectious infectious JJ cord-339328-wizu3arz 71 43 processes process NNS cord-339328-wizu3arz 71 44 such such JJ cord-339328-wizu3arz 71 45 as as IN cord-339328-wizu3arz 71 46 cancer cancer NN cord-339328-wizu3arz 71 47 or or CC cord-339328-wizu3arz 71 48 autoimmune autoimmune JJ cord-339328-wizu3arz 71 49 diseases disease NNS cord-339328-wizu3arz 71 50 . . . cord-339328-wizu3arz 72 1 Similarly similarly RB cord-339328-wizu3arz 72 2 , , , cord-339328-wizu3arz 72 3 highly highly RB cord-339328-wizu3arz 72 4 sensitive sensitive JJ cord-339328-wizu3arz 72 5 , , , cord-339328-wizu3arz 72 6 current current JJ cord-339328-wizu3arz 72 7 nuclear nuclear JJ cord-339328-wizu3arz 72 8 imaging imaging NN cord-339328-wizu3arz 72 9 tools tool NNS cord-339328-wizu3arz 72 10 such such JJ cord-339328-wizu3arz 72 11 as as IN cord-339328-wizu3arz 72 12 [ [ -LRB- cord-339328-wizu3arz 72 13 111 111 CD cord-339328-wizu3arz 72 14 In]oxine in]oxine NN cord-339328-wizu3arz 72 15 - - HYPH cord-339328-wizu3arz 72 16 tagged tag VBN cord-339328-wizu3arz 72 17 white white JJ cord-339328-wizu3arz 72 18 blood blood NN cord-339328-wizu3arz 72 19 cell cell NN cord-339328-wizu3arz 72 20 , , , cord-339328-wizu3arz 72 21 single single JJ cord-339328-wizu3arz 72 22 - - HYPH cord-339328-wizu3arz 72 23 photon photon NN cord-339328-wizu3arz 72 24 emission emission NN cord-339328-wizu3arz 72 25 computed compute VBN cord-339328-wizu3arz 72 26 tomography tomography NN cord-339328-wizu3arz 72 27 ( ( -LRB- cord-339328-wizu3arz 72 28 SPECT SPECT NNP cord-339328-wizu3arz 72 29 ) ) -RRB- cord-339328-wizu3arz 72 30 , , , cord-339328-wizu3arz 72 31 and and CC cord-339328-wizu3arz 72 32 [ [ -LRB- cord-339328-wizu3arz 72 33 18 18 CD cord-339328-wizu3arz 72 34 F]FDG f]fdg NN cord-339328-wizu3arz 72 35 PET pet NN cord-339328-wizu3arz 72 36 , , , cord-339328-wizu3arz 72 37 which which WDT cord-339328-wizu3arz 72 38 are be VBP cord-339328-wizu3arz 72 39 increasingly increasingly RB cord-339328-wizu3arz 72 40 being be VBG cord-339328-wizu3arz 72 41 used use VBN cord-339328-wizu3arz 72 42 for for IN cord-339328-wizu3arz 72 43 infections infection NNS cord-339328-wizu3arz 72 44 , , , cord-339328-wizu3arz 72 45 are be VBP cord-339328-wizu3arz 72 46 non non JJ cord-339328-wizu3arz 72 47 - - JJ cord-339328-wizu3arz 72 48 specific specific JJ cord-339328-wizu3arz 72 49 [ [ -LRB- cord-339328-wizu3arz 72 50 25 25 CD cord-339328-wizu3arz 72 51 ] ] -RRB- cord-339328-wizu3arz 72 52 . . . cord-339328-wizu3arz 73 1 Finally finally RB cord-339328-wizu3arz 73 2 , , , cord-339328-wizu3arz 73 3 all all PDT cord-339328-wizu3arz 73 4 these these DT cord-339328-wizu3arz 73 5 imaging imaging NN cord-339328-wizu3arz 73 6 tools tool NNS cord-339328-wizu3arz 73 7 are be VBP cord-339328-wizu3arz 73 8 dependent dependent JJ cord-339328-wizu3arz 73 9 upon upon IN cord-339328-wizu3arz 73 10 host host NN cord-339328-wizu3arz 73 11 responses response NNS cord-339328-wizu3arz 73 12 , , , cord-339328-wizu3arz 73 13 which which WDT cord-339328-wizu3arz 73 14 could could MD cord-339328-wizu3arz 73 15 be be VB cord-339328-wizu3arz 73 16 altered alter VBN cord-339328-wizu3arz 73 17 in in IN cord-339328-wizu3arz 73 18 immunosuppressed immunosuppressed JJ cord-339328-wizu3arz 73 19 states state NNS cord-339328-wizu3arz 73 20 ( ( -LRB- cord-339328-wizu3arz 73 21 e.g. e.g. RB cord-339328-wizu3arz 73 22 , , , cord-339328-wizu3arz 73 23 cancer cancer NN cord-339328-wizu3arz 73 24 , , , cord-339328-wizu3arz 73 25 AIDS AIDS NNP cord-339328-wizu3arz 73 26 ) ) -RRB- cord-339328-wizu3arz 73 27 . . . cord-339328-wizu3arz 74 1 Radiolabeled radiolabele VBN cord-339328-wizu3arz 74 2 antibiotics antibiotic NNS cord-339328-wizu3arz 74 3 or or CC cord-339328-wizu3arz 74 4 antimicrobial antimicrobial JJ cord-339328-wizu3arz 74 5 peptides peptide NNS cord-339328-wizu3arz 74 6 have have VBP cord-339328-wizu3arz 74 7 been be VBN cord-339328-wizu3arz 74 8 previously previously RB cord-339328-wizu3arz 74 9 tested test VBN cord-339328-wizu3arz 74 10 as as IN cord-339328-wizu3arz 74 11 pathogen pathogen NN cord-339328-wizu3arz 74 12 - - HYPH cord-339328-wizu3arz 74 13 specific specific JJ cord-339328-wizu3arz 74 14 imaging imaging NN cord-339328-wizu3arz 74 15 tracers tracer NNS cord-339328-wizu3arz 74 16 [ [ -LRB- cord-339328-wizu3arz 74 17 26 26 CD cord-339328-wizu3arz 74 18 , , , cord-339328-wizu3arz 74 19 27 27 CD cord-339328-wizu3arz 74 20 ] ] -RRB- cord-339328-wizu3arz 74 21 . . . cord-339328-wizu3arz 75 1 However however RB cord-339328-wizu3arz 75 2 , , , cord-339328-wizu3arz 75 3 radiolabeled radiolabele VBN cord-339328-wizu3arz 75 4 antibiotics antibiotic NNS cord-339328-wizu3arz 75 5 have have VBP cord-339328-wizu3arz 75 6 demonstrated demonstrate VBN cord-339328-wizu3arz 75 7 variable variable JJ cord-339328-wizu3arz 75 8 specificity specificity NN cord-339328-wizu3arz 75 9 and and CC cord-339328-wizu3arz 75 10 an an DT cord-339328-wizu3arz 75 11 inability inability NN cord-339328-wizu3arz 75 12 to to TO cord-339328-wizu3arz 75 13 reliably reliably RB cord-339328-wizu3arz 75 14 differentiate differentiate VB cord-339328-wizu3arz 75 15 infection infection NN cord-339328-wizu3arz 75 16 from from IN cord-339328-wizu3arz 75 17 sterile sterile JJ cord-339328-wizu3arz 75 18 inflammation inflammation NN cord-339328-wizu3arz 75 19 [ [ -LRB- cord-339328-wizu3arz 75 20 28 28 CD cord-339328-wizu3arz 75 21 ] ] -RRB- cord-339328-wizu3arz 75 22 . . . cord-339328-wizu3arz 76 1 Radiolabeled Radiolabeled NNP cord-339328-wizu3arz 76 2 peptides peptide NNS cord-339328-wizu3arz 76 3 lack lack VBP cord-339328-wizu3arz 76 4 mechanistic mechanistic JJ cord-339328-wizu3arz 76 5 binding binding NN cord-339328-wizu3arz 76 6 or or CC cord-339328-wizu3arz 76 7 uptake uptake NN cord-339328-wizu3arz 76 8 , , , cord-339328-wizu3arz 76 9 but but CC cord-339328-wizu3arz 76 10 recent recent JJ cord-339328-wizu3arz 76 11 PET pet JJ cord-339328-wizu3arz 76 12 tracers tracer NNS cord-339328-wizu3arz 76 13 may may MD cord-339328-wizu3arz 76 14 show show VB cord-339328-wizu3arz 76 15 promise promise NN cord-339328-wizu3arz 76 16 [ [ -LRB- cord-339328-wizu3arz 76 17 29 29 CD cord-339328-wizu3arz 76 18 ] ] -RRB- cord-339328-wizu3arz 76 19 . . . cord-339328-wizu3arz 77 1 Tracers tracer NNS cord-339328-wizu3arz 77 2 targeting target VBG cord-339328-wizu3arz 77 3 pathogen pathogen NN cord-339328-wizu3arz 77 4 - - HYPH cord-339328-wizu3arz 77 5 specific specific JJ cord-339328-wizu3arz 77 6 metabolic metabolic JJ cord-339328-wizu3arz 77 7 processes process NNS cord-339328-wizu3arz 77 8 have have VBP cord-339328-wizu3arz 77 9 also also RB cord-339328-wizu3arz 77 10 been be VBN cord-339328-wizu3arz 77 11 evaluated evaluate VBN cord-339328-wizu3arz 77 12 in in IN cord-339328-wizu3arz 77 13 preclinical preclinical JJ cord-339328-wizu3arz 77 14 studies study NNS cord-339328-wizu3arz 77 15 [ [ -LRB- cord-339328-wizu3arz 77 16 30 30 CD cord-339328-wizu3arz 77 17 , , , cord-339328-wizu3arz 77 18 31 31 CD cord-339328-wizu3arz 77 19 ] ] -RRB- cord-339328-wizu3arz 77 20 . . . cord-339328-wizu3arz 78 1 [ [ -LRB- cord-339328-wizu3arz 78 2 124 124 CD cord-339328-wizu3arz 78 3 I]FIAU i]fiau NN cord-339328-wizu3arz 78 4 , , , cord-339328-wizu3arz 78 5 a a DT cord-339328-wizu3arz 78 6 nucleoside nucleoside NN cord-339328-wizu3arz 78 7 analog analog NN cord-339328-wizu3arz 78 8 substrate substrate NN cord-339328-wizu3arz 78 9 for for IN cord-339328-wizu3arz 78 10 thymidine thymidine NN cord-339328-wizu3arz 78 11 kinase kinase NN cord-339328-wizu3arz 78 12 , , , cord-339328-wizu3arz 78 13 was be VBD cord-339328-wizu3arz 78 14 developed develop VBN cord-339328-wizu3arz 78 15 as as IN cord-339328-wizu3arz 78 16 a a DT cord-339328-wizu3arz 78 17 γ γ NN cord-339328-wizu3arz 78 18 - - HYPH cord-339328-wizu3arz 78 19 herpesvirus herpesvirus NN cord-339328-wizu3arz 78 20 and and CC cord-339328-wizu3arz 78 21 bacteria bacteria NNS cord-339328-wizu3arz 78 22 - - HYPH cord-339328-wizu3arz 78 23 specific specific JJ cord-339328-wizu3arz 78 24 tracer tracer NN cord-339328-wizu3arz 78 25 [ [ -LRB- cord-339328-wizu3arz 78 26 32 32 CD cord-339328-wizu3arz 78 27 ] ] -RRB- cord-339328-wizu3arz 78 28 but but CC cord-339328-wizu3arz 78 29 was be VBD cord-339328-wizu3arz 78 30 later later RB cord-339328-wizu3arz 78 31 found find VBN cord-339328-wizu3arz 78 32 to to IN cord-339328-wizu3arz 78 33 lack lack VB cord-339328-wizu3arz 78 34 specificity specificity NN cord-339328-wizu3arz 78 35 , , , cord-339328-wizu3arz 78 36 presumably presumably RB cord-339328-wizu3arz 78 37 due due JJ cord-339328-wizu3arz 78 38 to to TO cord-339328-wizu3arz 78 39 host host NN cord-339328-wizu3arz 78 40 mitochondrial mitochondrial JJ cord-339328-wizu3arz 78 41 metabolism metabolism NN cord-339328-wizu3arz 78 42 PET PET NNP cord-339328-wizu3arz 78 43 could could MD cord-339328-wizu3arz 78 44 specifically specifically RB cord-339328-wizu3arz 78 45 detect detect VB cord-339328-wizu3arz 78 46 Enterobacteriaceae Enterobacteriaceae NNP cord-339328-wizu3arz 78 47 in in IN cord-339328-wizu3arz 78 48 vivo vivo NN cord-339328-wizu3arz 78 49 in in IN cord-339328-wizu3arz 78 50 various various JJ cord-339328-wizu3arz 78 51 different different JJ cord-339328-wizu3arz 78 52 sites site NNS cord-339328-wizu3arz 78 53 including include VBG cord-339328-wizu3arz 78 54 the the DT cord-339328-wizu3arz 78 55 brain brain NN cord-339328-wizu3arz 78 56 , , , cord-339328-wizu3arz 78 57 and and CC cord-339328-wizu3arz 78 58 the the DT cord-339328-wizu3arz 78 59 PET pet JJ cord-339328-wizu3arz 78 60 signal signal NN cord-339328-wizu3arz 78 61 was be VBD cord-339328-wizu3arz 78 62 not not RB cord-339328-wizu3arz 78 63 affected affect VBN cord-339328-wizu3arz 78 64 by by IN cord-339328-wizu3arz 78 65 immunosuppressive immunosuppressive JJ cord-339328-wizu3arz 78 66 cancer cancer NN cord-339328-wizu3arz 78 67 treatments treatment NNS cord-339328-wizu3arz 78 68 [ [ -LRB- cord-339328-wizu3arz 78 69 36 36 CD cord-339328-wizu3arz 78 70 ] ] -RRB- cord-339328-wizu3arz 78 71 . . . cord-339328-wizu3arz 79 1 F-18 F-18 NNP cord-339328-wizu3arz 79 2 analogs analog NNS cord-339328-wizu3arz 79 3 of of IN cord-339328-wizu3arz 79 4 trehalose trehalose NNS cord-339328-wizu3arz 79 5 have have VBP cord-339328-wizu3arz 79 6 also also RB cord-339328-wizu3arz 79 7 been be VBN cord-339328-wizu3arz 79 8 developed develop VBN cord-339328-wizu3arz 79 9 as as IN cord-339328-wizu3arz 79 10 potential potential JJ cord-339328-wizu3arz 79 11 imaging imaging NN cord-339328-wizu3arz 79 12 agents agent NNS cord-339328-wizu3arz 79 13 for for IN cord-339328-wizu3arz 79 14 mycobacteria mycobacterium NNS cord-339328-wizu3arz 79 15 [ [ -LRB- cord-339328-wizu3arz 79 16 37 37 CD cord-339328-wizu3arz 79 17 ] ] -RRB- cord-339328-wizu3arz 79 18 , , , cord-339328-wizu3arz 79 19 while while IN cord-339328-wizu3arz 79 20 Aspergillus aspergillus NN cord-339328-wizu3arz 79 21 fumigatus fumigatus NN cord-339328-wizu3arz 79 22 has have VBZ cord-339328-wizu3arz 79 23 been be VBN cord-339328-wizu3arz 79 24 imaged image VBN cord-339328-wizu3arz 79 25 in in IN cord-339328-wizu3arz 79 26 vivo vivo NN cord-339328-wizu3arz 79 27 using use VBG cord-339328-wizu3arz 79 28 Ga-68-radiolabeled ga-68-radiolabele VBN cord-339328-wizu3arz 79 29 siderophores siderophore NNS cord-339328-wizu3arz 79 30 [ [ -LRB- cord-339328-wizu3arz 79 31 38 38 CD cord-339328-wizu3arz 79 32 ] ] -RRB- cord-339328-wizu3arz 79 33 . . . cord-339328-wizu3arz 80 1 Investigators investigator NNS cord-339328-wizu3arz 80 2 have have VBP cord-339328-wizu3arz 80 3 also also RB cord-339328-wizu3arz 80 4 utilized utilize VBN cord-339328-wizu3arz 80 5 radiolabeled radiolabele VBN cord-339328-wizu3arz 80 6 antibodies antibody NNS cord-339328-wizu3arz 80 7 to to TO cord-339328-wizu3arz 80 8 image image VB cord-339328-wizu3arz 80 9 A. a. NN cord-339328-wizu3arz 80 10 fumigatus fumigatus NN cord-339328-wizu3arz 80 11 and and CC cord-339328-wizu3arz 80 12 Yersinia Yersinia NNP cord-339328-wizu3arz 80 13 in in IN cord-339328-wizu3arz 80 14 murine murine JJ cord-339328-wizu3arz 80 15 models model NNS cord-339328-wizu3arz 80 16 [ [ -LRB- cord-339328-wizu3arz 80 17 39 39 CD cord-339328-wizu3arz 80 18 , , , cord-339328-wizu3arz 80 19 40 40 CD cord-339328-wizu3arz 80 20 ] ] -RRB- cord-339328-wizu3arz 80 21 . . . cord-339328-wizu3arz 81 1 Similarly similarly RB cord-339328-wizu3arz 81 2 , , , cord-339328-wizu3arz 81 3 Santangelo Santangelo NNP cord-339328-wizu3arz 81 4 et et NNP cord-339328-wizu3arz 81 5 al al NNP cord-339328-wizu3arz 81 6 . . NNP cord-339328-wizu3arz 81 7 developed develop VBD cord-339328-wizu3arz 81 8 a a DT cord-339328-wizu3arz 81 9 technique technique NN cord-339328-wizu3arz 81 10 to to TO cord-339328-wizu3arz 81 11 image image VB cord-339328-wizu3arz 81 12 simian simian JJ cord-339328-wizu3arz 81 13 immunodeficiency immunodeficiency NN cord-339328-wizu3arz 81 14 virus virus NN cord-339328-wizu3arz 81 15 ( ( -LRB- cord-339328-wizu3arz 81 16 SIV SIV NNP cord-339328-wizu3arz 81 17 ) ) -RRB- cord-339328-wizu3arz 81 18 replication replication NN cord-339328-wizu3arz 81 19 using use VBG cord-339328-wizu3arz 81 20 a a DT cord-339328-wizu3arz 81 21 Cu-64-labeled cu-64-labeled JJ cord-339328-wizu3arz 81 22 SIV SIV NNP cord-339328-wizu3arz 81 23 Gp120-specific gp120-specific JJ cord-339328-wizu3arz 81 24 antibody antibody NN cord-339328-wizu3arz 81 25 and and CC cord-339328-wizu3arz 81 26 were be VBD cord-339328-wizu3arz 81 27 able able JJ cord-339328-wizu3arz 81 28 to to TO cord-339328-wizu3arz 81 29 detect detect VB cord-339328-wizu3arz 81 30 virus virus NN cord-339328-wizu3arz 81 31 - - HYPH cord-339328-wizu3arz 81 32 specific specific JJ cord-339328-wizu3arz 81 33 PET pet NN cord-339328-wizu3arz 81 34 signals signal NNS cord-339328-wizu3arz 81 35 in in IN cord-339328-wizu3arz 81 36 treated treat VBN cord-339328-wizu3arz 81 37 and and CC cord-339328-wizu3arz 81 38 untreated untreated JJ cord-339328-wizu3arz 81 39 monkeys monkey NNS cord-339328-wizu3arz 81 40 [ [ -LRB- cord-339328-wizu3arz 81 41 41 41 CD cord-339328-wizu3arz 81 42 ] ] -RRB- cord-339328-wizu3arz 81 43 . . . cord-339328-wizu3arz 82 1 Other other JJ cord-339328-wizu3arz 82 2 approaches approach NNS cord-339328-wizu3arz 82 3 have have VBP cord-339328-wizu3arz 82 4 utilized utilize VBN cord-339328-wizu3arz 82 5 Tc-99m tc-99m NN cord-339328-wizu3arz 82 6 - - HYPH cord-339328-wizu3arz 82 7 labeled label VBN cord-339328-wizu3arz 82 8 oligomers oligomer NNS cord-339328-wizu3arz 82 9 to to TO cord-339328-wizu3arz 82 10 specifically specifically RB cord-339328-wizu3arz 82 11 target target VB cord-339328-wizu3arz 82 12 the the DT cord-339328-wizu3arz 82 13 ribosomal ribosomal JJ cord-339328-wizu3arz 82 14 RNA RNA NNP cord-339328-wizu3arz 82 15 in in IN cord-339328-wizu3arz 82 16 the the DT cord-339328-wizu3arz 82 17 pathogen pathogen NN cord-339328-wizu3arz 82 18 [ [ -LRB- cord-339328-wizu3arz 82 19 42 42 CD cord-339328-wizu3arz 82 20 , , , cord-339328-wizu3arz 82 21 43 43 CD cord-339328-wizu3arz 82 22 ] ] -RRB- cord-339328-wizu3arz 82 23 . . . cord-339328-wizu3arz 83 1 Finally finally RB cord-339328-wizu3arz 83 2 , , , cord-339328-wizu3arz 83 3 using use VBG cord-339328-wizu3arz 83 4 endogenous endogenous JJ cord-339328-wizu3arz 83 5 CEST CEST NNP cord-339328-wizu3arz 83 6 contrast contrast NN cord-339328-wizu3arz 83 7 , , , cord-339328-wizu3arz 83 8 Liu Liu NNP cord-339328-wizu3arz 83 9 et et NNP cord-339328-wizu3arz 83 10 al al NNP cord-339328-wizu3arz 83 11 . . NNP cord-339328-wizu3arz 83 12 were be VBD cord-339328-wizu3arz 83 13 able able JJ cord-339328-wizu3arz 83 14 to to TO cord-339328-wizu3arz 83 15 image image VB cord-339328-wizu3arz 83 16 bacteria bacteria NNS cord-339328-wizu3arz 83 17 - - HYPH cord-339328-wizu3arz 83 18 specific specific JJ cord-339328-wizu3arz 83 19 MRI MRI NNP cord-339328-wizu3arz 83 20 signals signal NNS cord-339328-wizu3arz 83 21 from from IN cord-339328-wizu3arz 83 22 C. C. NNP cord-339328-wizu3arz 83 23 novyi novyi NNS cord-339328-wizu3arz 83 24 - - HYPH cord-339328-wizu3arz 83 25 NT NT NNP cord-339328-wizu3arz 83 26 - - HYPH cord-339328-wizu3arz 83 27 infected infect VBN cord-339328-wizu3arz 83 28 tumors tumor NNS cord-339328-wizu3arz 83 29 in in IN cord-339328-wizu3arz 83 30 mice mouse NNS cord-339328-wizu3arz 83 31 [ [ -LRB- cord-339328-wizu3arz 83 32 44 44 CD cord-339328-wizu3arz 83 33 ] ] -RRB- cord-339328-wizu3arz 83 34 . . . cord-339328-wizu3arz 84 1 Noninvasive noninvasive JJ cord-339328-wizu3arz 84 2 imaging imaging NN cord-339328-wizu3arz 84 3 , , , cord-339328-wizu3arz 84 4 including include VBG cord-339328-wizu3arz 84 5 non non JJ cord-339328-wizu3arz 84 6 - - JJ cord-339328-wizu3arz 84 7 specific specific JJ cord-339328-wizu3arz 84 8 agents agent NNS cord-339328-wizu3arz 84 9 , , , cord-339328-wizu3arz 84 10 can can MD cord-339328-wizu3arz 84 11 be be VB cord-339328-wizu3arz 84 12 used use VBN cord-339328-wizu3arz 84 13 to to TO cord-339328-wizu3arz 84 14 monitor monitor VB cord-339328-wizu3arz 84 15 disease disease NN cord-339328-wizu3arz 84 16 , , , cord-339328-wizu3arz 84 17 and and CC cord-339328-wizu3arz 84 18 serial serial JJ cord-339328-wizu3arz 84 19 imaging imaging NN cord-339328-wizu3arz 84 20 has have VBZ cord-339328-wizu3arz 84 21 been be VBN cord-339328-wizu3arz 84 22 used use VBN cord-339328-wizu3arz 84 23 to to TO cord-339328-wizu3arz 84 24 assess assess VB cord-339328-wizu3arz 84 25 antimicrobial antimicrobial JJ cord-339328-wizu3arz 84 26 treatments treatment NNS cord-339328-wizu3arz 84 27 in in IN cord-339328-wizu3arz 84 28 animals animal NNS cord-339328-wizu3arz 84 29 and and CC cord-339328-wizu3arz 84 30 humans human NNS cord-339328-wizu3arz 84 31 [ [ -LRB- cord-339328-wizu3arz 84 32 9 9 CD cord-339328-wizu3arz 84 33 , , , cord-339328-wizu3arz 84 34 [ [ -LRB- cord-339328-wizu3arz 84 35 45 45 CD cord-339328-wizu3arz 84 36 ] ] -RRB- cord-339328-wizu3arz 84 37 [ [ -LRB- cord-339328-wizu3arz 84 38 46 46 CD cord-339328-wizu3arz 84 39 ] ] -RRB- cord-339328-wizu3arz 84 40 [ [ -LRB- cord-339328-wizu3arz 84 41 47 47 CD cord-339328-wizu3arz 84 42 ] ] -RRB- cord-339328-wizu3arz 84 43 . . . cord-339328-wizu3arz 85 1 For for IN cord-339328-wizu3arz 85 2 example example NN cord-339328-wizu3arz 85 3 , , , cord-339328-wizu3arz 85 4 phase phase NN cord-339328-wizu3arz 85 5 III iii CD cord-339328-wizu3arz 85 6 TB TB NNP cord-339328-wizu3arz 85 7 trials trial NNS cord-339328-wizu3arz 85 8 entail entail VBP cord-339328-wizu3arz 85 9 treating treat VBG cord-339328-wizu3arz 85 10 hundreds hundred NNS cord-339328-wizu3arz 85 11 of of IN cord-339328-wizu3arz 85 12 patients patient NNS cord-339328-wizu3arz 85 13 ≥6 ≥6 NNP cord-339328-wizu3arz 85 14 months month NNS cord-339328-wizu3arz 85 15 and and CC cord-339328-wizu3arz 85 16 monitoring monitor VBG cord-339328-wizu3arz 85 17 for for IN cord-339328-wizu3arz 85 18 ≥1 ≥1 NNP cord-339328-wizu3arz 85 19 year year NN cord-339328-wizu3arz 85 20 thereafter thereafter RB cord-339328-wizu3arz 85 21 for for IN cord-339328-wizu3arz 85 22 relapse relapse NN cord-339328-wizu3arz 85 23 [ [ -LRB- cord-339328-wizu3arz 85 24 48 48 CD cord-339328-wizu3arz 85 25 ] ] -RRB- cord-339328-wizu3arz 85 26 . . . cord-339328-wizu3arz 86 1 As as IN cord-339328-wizu3arz 86 2 M. M. NNP cord-339328-wizu3arz 86 3 tuberculosis tuberculosis NN cord-339328-wizu3arz 86 4 can can MD cord-339328-wizu3arz 86 5 infect infect VB cord-339328-wizu3arz 86 6 any any DT cord-339328-wizu3arz 86 7 part part NN cord-339328-wizu3arz 86 8 of of IN cord-339328-wizu3arz 86 9 the the DT cord-339328-wizu3arz 86 10 lung lung NN cord-339328-wizu3arz 86 11 ( ( -LRB- cord-339328-wizu3arz 86 12 or or CC cord-339328-wizu3arz 86 13 extra extra JJ cord-339328-wizu3arz 86 14 - - JJ cord-339328-wizu3arz 86 15 pulmonary pulmonary JJ cord-339328-wizu3arz 86 16 sites site NNS cord-339328-wizu3arz 86 17 ) ) -RRB- cord-339328-wizu3arz 86 18 , , , cord-339328-wizu3arz 86 19 traditional traditional JJ cord-339328-wizu3arz 86 20 tools tool NNS cord-339328-wizu3arz 86 21 such such JJ cord-339328-wizu3arz 86 22 as as IN cord-339328-wizu3arz 86 23 sputum sputum NN cord-339328-wizu3arz 86 24 culture culture NN cord-339328-wizu3arz 86 25 or or CC cord-339328-wizu3arz 86 26 NAA NAA NNP cord-339328-wizu3arz 86 27 ( ( -LRB- cord-339328-wizu3arz 86 28 e.g. e.g. RB cord-339328-wizu3arz 86 29 , , , cord-339328-wizu3arz 86 30 Xpert Xpert NNP cord-339328-wizu3arz 86 31 ® ® NNP cord-339328-wizu3arz 86 32 MTB MTB NNP cord-339328-wizu3arz 86 33 / / SYM cord-339328-wizu3arz 86 34 RIF RIF NNP cord-339328-wizu3arz 86 35 ) ) -RRB- cord-339328-wizu3arz 86 36 do do VBP cord-339328-wizu3arz 86 37 not not RB cord-339328-wizu3arz 86 38 always always RB cord-339328-wizu3arz 86 39 correlate correlate VB cord-339328-wizu3arz 86 40 with with IN cord-339328-wizu3arz 86 41 the the DT cord-339328-wizu3arz 86 42 overall overall JJ cord-339328-wizu3arz 86 43 disease disease NN cord-339328-wizu3arz 86 44 burden burden NN cord-339328-wizu3arz 86 45 . . . cord-339328-wizu3arz 87 1 Recently recently RB cord-339328-wizu3arz 87 2 , , , cord-339328-wizu3arz 87 3 Chen Chen NNP cord-339328-wizu3arz 87 4 et et NNP cord-339328-wizu3arz 87 5 al al NNP cord-339328-wizu3arz 87 6 . . NNP cord-339328-wizu3arz 87 7 reported report VBD cord-339328-wizu3arz 87 8 that that IN cord-339328-wizu3arz 87 9 [ [ -LRB- cord-339328-wizu3arz 87 10 18 18 CD cord-339328-wizu3arz 87 11 F]FDG f]fdg NN cord-339328-wizu3arz 87 12 PET pet NN cord-339328-wizu3arz 87 13 and and CC cord-339328-wizu3arz 87 14 CT CT NNP cord-339328-wizu3arz 87 15 imaging imaging NN cord-339328-wizu3arz 87 16 were be VBD cord-339328-wizu3arz 87 17 superior superior JJ cord-339328-wizu3arz 87 18 to to IN cord-339328-wizu3arz 87 19 traditional traditional JJ cord-339328-wizu3arz 87 20 ( ( -LRB- cord-339328-wizu3arz 87 21 sputum sputum NN cord-339328-wizu3arz 87 22 ) ) -RRB- cord-339328-wizu3arz 87 23 microbiology microbiology NN cord-339328-wizu3arz 87 24 for for IN cord-339328-wizu3arz 87 25 monitoring monitor VBG cord-339328-wizu3arz 87 26 response response NN cord-339328-wizu3arz 87 27 to to IN cord-339328-wizu3arz 87 28 treatments treatment NNS cord-339328-wizu3arz 87 29 in in IN cord-339328-wizu3arz 87 30 adults adult NNS cord-339328-wizu3arz 87 31 with with IN cord-339328-wizu3arz 87 32 MDR MDR NNP cord-339328-wizu3arz 87 33 - - HYPH cord-339328-wizu3arz 87 34 TB TB NNP cord-339328-wizu3arz 87 35 [ [ -LRB- cord-339328-wizu3arz 87 36 49 49 CD cord-339328-wizu3arz 87 37 ] ] -RRB- cord-339328-wizu3arz 87 38 . . . cord-339328-wizu3arz 88 1 In in IN cord-339328-wizu3arz 88 2 this this DT cord-339328-wizu3arz 88 3 study study NN cord-339328-wizu3arz 88 4 , , , cord-339328-wizu3arz 88 5 quantitative quantitative JJ cord-339328-wizu3arz 88 6 changes change NNS cord-339328-wizu3arz 88 7 in in IN cord-339328-wizu3arz 88 8 lesion lesion NN cord-339328-wizu3arz 88 9 volumes volume NNS cord-339328-wizu3arz 88 10 on on IN cord-339328-wizu3arz 88 11 CT CT NNP cord-339328-wizu3arz 88 12 imaging imaging NN cord-339328-wizu3arz 88 13 were be VBD cord-339328-wizu3arz 88 14 predictive predictive JJ cord-339328-wizu3arz 88 15 of of IN cord-339328-wizu3arz 88 16 treatment treatment NN cord-339328-wizu3arz 88 17 responses response NNS cord-339328-wizu3arz 88 18 . . . cord-339328-wizu3arz 89 1 Moreover moreover RB cord-339328-wizu3arz 89 2 , , , cord-339328-wizu3arz 89 3 quantitative quantitative JJ cord-339328-wizu3arz 89 4 changes change NNS cord-339328-wizu3arz 89 5 in in IN cord-339328-wizu3arz 89 6 [ [ -LRB- cord-339328-wizu3arz 89 7 18 18 CD cord-339328-wizu3arz 89 8 F]FDG f]fdg NN cord-339328-wizu3arz 89 9 PET pet NN cord-339328-wizu3arz 89 10 not not RB cord-339328-wizu3arz 89 11 only only RB cord-339328-wizu3arz 89 12 correlated correlate VBN cord-339328-wizu3arz 89 13 with with IN cord-339328-wizu3arz 89 14 treatment treatment NN cord-339328-wizu3arz 89 15 responses response NNS cord-339328-wizu3arz 89 16 but but CC cord-339328-wizu3arz 89 17 were be VBD cord-339328-wizu3arz 89 18 also also RB cord-339328-wizu3arz 89 19 predictive predictive JJ cord-339328-wizu3arz 89 20 of of IN cord-339328-wizu3arz 89 21 long long JJ cord-339328-wizu3arz 89 22 - - HYPH cord-339328-wizu3arz 89 23 term term NN cord-339328-wizu3arz 89 24 treatment treatment NN cord-339328-wizu3arz 89 25 outcomes outcome NNS cord-339328-wizu3arz 89 26 . . . cord-339328-wizu3arz 90 1 In in IN cord-339328-wizu3arz 90 2 another another DT cord-339328-wizu3arz 90 3 more more RBR cord-339328-wizu3arz 90 4 recent recent JJ cord-339328-wizu3arz 90 5 study study NN cord-339328-wizu3arz 90 6 , , , cord-339328-wizu3arz 90 7 given give VBN cord-339328-wizu3arz 90 8 the the DT cord-339328-wizu3arz 90 9 absence absence NN cord-339328-wizu3arz 90 10 of of IN cord-339328-wizu3arz 90 11 clinical clinical JJ cord-339328-wizu3arz 90 12 or or CC cord-339328-wizu3arz 90 13 microbiological microbiological JJ cord-339328-wizu3arz 90 14 markers marker NNS cord-339328-wizu3arz 90 15 of of IN cord-339328-wizu3arz 90 16 disease disease NN cord-339328-wizu3arz 90 17 , , , cord-339328-wizu3arz 90 18 low low JJ cord-339328-wizu3arz 90 19 - - HYPH cord-339328-wizu3arz 90 20 radiation radiation NN cord-339328-wizu3arz 90 21 exposure exposure NN cord-339328-wizu3arz 90 22 pulmonary pulmonary JJ cord-339328-wizu3arz 90 23 CT CT NNP cord-339328-wizu3arz 90 24 imaging imaging NN cord-339328-wizu3arz 90 25 was be VBD cord-339328-wizu3arz 90 26 successfully successfully RB cord-339328-wizu3arz 90 27 used use VBN cord-339328-wizu3arz 90 28 to to TO cord-339328-wizu3arz 90 29 monitor monitor VB cord-339328-wizu3arz 90 30 treatment treatment NN cord-339328-wizu3arz 90 31 response response NN cord-339328-wizu3arz 90 32 in in IN cord-339328-wizu3arz 90 33 a a DT cord-339328-wizu3arz 90 34 2-year 2-year CD cord-339328-wizu3arz 90 35 - - HYPH cord-339328-wizu3arz 90 36 old old JJ cord-339328-wizu3arz 90 37 child child NN cord-339328-wizu3arz 90 38 with with IN cord-339328-wizu3arz 90 39 XDR XDR NNP cord-339328-wizu3arz 90 40 - - HYPH cord-339328-wizu3arz 90 41 TB TB NNP cord-339328-wizu3arz 90 42 and and CC cord-339328-wizu3arz 90 43 guide guide VB cord-339328-wizu3arz 90 44 an an DT cord-339328-wizu3arz 90 45 individualized individualized JJ cord-339328-wizu3arz 90 46 drug drug NN cord-339328-wizu3arz 90 47 regimen regimen NN cord-339328-wizu3arz 90 48 [ [ -LRB- cord-339328-wizu3arz 90 49 9 9 CD cord-339328-wizu3arz 90 50 ] ] -RRB- cord-339328-wizu3arz 90 51 . . . cord-339328-wizu3arz 91 1 Imaging imaging NN cord-339328-wizu3arz 91 2 agents agent NNS cord-339328-wizu3arz 91 3 with with IN cord-339328-wizu3arz 91 4 higher high JJR cord-339328-wizu3arz 91 5 specificity specificity NN cord-339328-wizu3arz 91 6 for for IN cord-339328-wizu3arz 91 7 TB TB NNP cord-339328-wizu3arz 91 8 - - HYPH cord-339328-wizu3arz 91 9 associated associate VBN cord-339328-wizu3arz 91 10 inflammation inflammation NN cord-339328-wizu3arz 91 11 have have VBP cord-339328-wizu3arz 91 12 been be VBN cord-339328-wizu3arz 91 13 shown show VBN cord-339328-wizu3arz 91 14 to to TO cord-339328-wizu3arz 91 15 be be VB cord-339328-wizu3arz 91 16 promising promise VBG cord-339328-wizu3arz 91 17 in in IN cord-339328-wizu3arz 91 18 animal animal NN cord-339328-wizu3arz 91 19 models model NNS cord-339328-wizu3arz 91 20 [ [ -LRB- cord-339328-wizu3arz 91 21 45 45 CD cord-339328-wizu3arz 91 22 ] ] -RRB- cord-339328-wizu3arz 91 23 . . . cord-339328-wizu3arz 92 1 Pathogen pathogen NN cord-339328-wizu3arz 92 2 - - HYPH cord-339328-wizu3arz 92 3 specific specific JJ cord-339328-wizu3arz 92 4 imaging imaging NN cord-339328-wizu3arz 92 5 could could MD cord-339328-wizu3arz 92 6 be be VB cord-339328-wizu3arz 92 7 an an DT cord-339328-wizu3arz 92 8 even even RB cord-339328-wizu3arz 92 9 better well JJR cord-339328-wizu3arz 92 10 predictor predictor NN cord-339328-wizu3arz 92 11 of of IN cord-339328-wizu3arz 92 12 treatment treatment NN cord-339328-wizu3arz 92 13 responses response NNS cord-339328-wizu3arz 92 14 [ [ -LRB- cord-339328-wizu3arz 92 15 36 36 CD cord-339328-wizu3arz 92 16 ] ] -RRB- cord-339328-wizu3arz 92 17 . . . cord-339328-wizu3arz 93 1 For for IN cord-339328-wizu3arz 93 2 example example NN cord-339328-wizu3arz 93 3 , , , cord-339328-wizu3arz 93 4 both both DT cord-339328-wizu3arz 93 5 18 18 CD cord-339328-wizu3arz 93 6 F F NNP cord-339328-wizu3arz 93 7 - - HYPH cord-339328-wizu3arz 93 8 labeled label VBN cord-339328-wizu3arz 93 9 maltohexaose maltohexaose NN cord-339328-wizu3arz 93 10 and and CC cord-339328-wizu3arz 93 11 [ [ -LRB- cord-339328-wizu3arz 93 12 18 18 CD cord-339328-wizu3arz 93 13 F]FDS f]fd NNS cord-339328-wizu3arz 93 14 PET PET NNP cord-339328-wizu3arz 93 15 could could MD cord-339328-wizu3arz 93 16 rapidly rapidly RB cord-339328-wizu3arz 93 17 identify identify VB cord-339328-wizu3arz 93 18 therapeutic therapeutic JJ cord-339328-wizu3arz 93 19 failures failure NNS cord-339328-wizu3arz 93 20 associated associate VBN cord-339328-wizu3arz 93 21 with with IN cord-339328-wizu3arz 93 22 drug drug NN cord-339328-wizu3arz 93 23 - - HYPH cord-339328-wizu3arz 93 24 resistant resistant JJ cord-339328-wizu3arz 93 25 infections infection NNS cord-339328-wizu3arz 93 26 [ [ -LRB- cord-339328-wizu3arz 93 27 34 34 CD cord-339328-wizu3arz 93 28 , , , cord-339328-wizu3arz 93 29 36 36 CD cord-339328-wizu3arz 93 30 ] ] -RRB- cord-339328-wizu3arz 93 31 . . . cord-339328-wizu3arz 94 1 Given give VBN cord-339328-wizu3arz 94 2 that that IN cord-339328-wizu3arz 94 3 several several JJ cord-339328-wizu3arz 94 4 infectious infectious JJ cord-339328-wizu3arz 94 5 agents agent NNS cord-339328-wizu3arz 94 6 are be VBP cord-339328-wizu3arz 94 7 easily easily RB cord-339328-wizu3arz 94 8 transmissible transmissible JJ cord-339328-wizu3arz 94 9 ( ( -LRB- cord-339328-wizu3arz 94 10 e.g. e.g. RB cord-339328-wizu3arz 94 11 , , , cord-339328-wizu3arz 94 12 via via IN cord-339328-wizu3arz 94 13 aerosol aerosol NN cord-339328-wizu3arz 94 14 ) ) -RRB- cord-339328-wizu3arz 94 15 , , , cord-339328-wizu3arz 94 16 imaging imaging NN cord-339328-wizu3arz 94 17 could could MD cord-339328-wizu3arz 94 18 also also RB cord-339328-wizu3arz 94 19 help help VB cord-339328-wizu3arz 94 20 with with IN cord-339328-wizu3arz 94 21 rapid rapid JJ cord-339328-wizu3arz 94 22 determination determination NN cord-339328-wizu3arz 94 23 of of IN cord-339328-wizu3arz 94 24 the the DT cord-339328-wizu3arz 94 25 infectious infectious JJ cord-339328-wizu3arz 94 26 risk risk NN cord-339328-wizu3arz 94 27 of of IN cord-339328-wizu3arz 94 28 a a DT cord-339328-wizu3arz 94 29 patient patient NN cord-339328-wizu3arz 94 30 to to IN cord-339328-wizu3arz 94 31 the the DT cord-339328-wizu3arz 94 32 population population NN cord-339328-wizu3arz 94 33 . . . cord-339328-wizu3arz 95 1 This this DT cord-339328-wizu3arz 95 2 could could MD cord-339328-wizu3arz 95 3 be be VB cord-339328-wizu3arz 95 4 especially especially RB cord-339328-wizu3arz 95 5 relevant relevant JJ cord-339328-wizu3arz 95 6 for for IN cord-339328-wizu3arz 95 7 highly highly RB cord-339328-wizu3arz 95 8 drug drug NN cord-339328-wizu3arz 95 9 - - HYPH cord-339328-wizu3arz 95 10 resistant resistant JJ cord-339328-wizu3arz 95 11 organisms organism NNS cord-339328-wizu3arz 95 12 or or CC cord-339328-wizu3arz 95 13 biothreat biothreat NN cord-339328-wizu3arz 95 14 agents agent NNS cord-339328-wizu3arz 95 15 , , , cord-339328-wizu3arz 95 16 where where WRB cord-339328-wizu3arz 95 17 rapid rapid JJ cord-339328-wizu3arz 95 18 diagnosis diagnosis NN cord-339328-wizu3arz 95 19 and and CC cord-339328-wizu3arz 95 20 therapeutic therapeutic JJ cord-339328-wizu3arz 95 21 monitoring monitoring NN cord-339328-wizu3arz 95 22 would would MD cord-339328-wizu3arz 95 23 be be VB cord-339328-wizu3arz 95 24 critical critical JJ cord-339328-wizu3arz 95 25 to to TO cord-339328-wizu3arz 95 26 prevent prevent VB cord-339328-wizu3arz 95 27 spread spread NN cord-339328-wizu3arz 95 28 to to IN cord-339328-wizu3arz 95 29 others other NNS cord-339328-wizu3arz 95 30 in in IN cord-339328-wizu3arz 95 31 the the DT cord-339328-wizu3arz 95 32 community community NN cord-339328-wizu3arz 95 33 . . . cord-339328-wizu3arz 96 1 A a DT cord-339328-wizu3arz 96 2 large large JJ cord-339328-wizu3arz 96 3 majority majority NN cord-339328-wizu3arz 96 4 of of IN cord-339328-wizu3arz 96 5 infectious infectious JJ cord-339328-wizu3arz 96 6 pathogens pathogen NNS cord-339328-wizu3arz 96 7 can can MD cord-339328-wizu3arz 96 8 be be VB cord-339328-wizu3arz 96 9 handled handle VBN cord-339328-wizu3arz 96 10 using use VBG cord-339328-wizu3arz 96 11 standard standard JJ cord-339328-wizu3arz 96 12 precautions precaution NNS cord-339328-wizu3arz 96 13 . . . cord-339328-wizu3arz 97 1 However however RB cord-339328-wizu3arz 97 2 , , , cord-339328-wizu3arz 97 3 animals animal NNS cord-339328-wizu3arz 97 4 infected infect VBN cord-339328-wizu3arz 97 5 with with IN cord-339328-wizu3arz 97 6 pathogens pathogen NNS cord-339328-wizu3arz 97 7 designated designate VBN cord-339328-wizu3arz 97 8 as as IN cord-339328-wizu3arz 97 9 biosafety biosafety NN cord-339328-wizu3arz 97 10 level level NN cord-339328-wizu3arz 97 11 3/4 3/4 . cord-339328-wizu3arz 97 12 ( ( -LRB- cord-339328-wizu3arz 97 13 BSL-3/4 bsl-3/4 VB cord-339328-wizu3arz 97 14 ) ) -RRB- cord-339328-wizu3arz 97 15 require require VB cord-339328-wizu3arz 97 16 appropriate appropriate JJ cord-339328-wizu3arz 97 17 containment containment NN cord-339328-wizu3arz 97 18 . . . cord-339328-wizu3arz 98 1 In in IN cord-339328-wizu3arz 98 2 addition addition NN cord-339328-wizu3arz 98 3 , , , cord-339328-wizu3arz 98 4 work work VB cord-339328-wizu3arz 98 5 with with IN cord-339328-wizu3arz 98 6 biothreat biothreat NN cord-339328-wizu3arz 98 7 pathogens pathogen NNS cord-339328-wizu3arz 98 8 requires require VBZ cord-339328-wizu3arz 98 9 regulatory regulatory JJ cord-339328-wizu3arz 98 10 approvals approval NNS cord-339328-wizu3arz 98 11 , , , cord-339328-wizu3arz 98 12 as as RB cord-339328-wizu3arz 98 13 well well RB cord-339328-wizu3arz 98 14 as as IN cord-339328-wizu3arz 98 15 highly highly RB cord-339328-wizu3arz 98 16 trained train VBN cord-339328-wizu3arz 98 17 personnel personnel NNS cord-339328-wizu3arz 98 18 [ [ -LRB- cord-339328-wizu3arz 98 19 50 50 CD cord-339328-wizu3arz 98 20 ] ] -RRB- cord-339328-wizu3arz 98 21 . . . cord-339328-wizu3arz 99 1 To to TO cord-339328-wizu3arz 99 2 achieve achieve VB cord-339328-wizu3arz 99 3 containment containment NN cord-339328-wizu3arz 99 4 , , , cord-339328-wizu3arz 99 5 several several JJ cord-339328-wizu3arz 99 6 groups group NNS cord-339328-wizu3arz 99 7 have have VBP cord-339328-wizu3arz 99 8 installed instal VBN cord-339328-wizu3arz 99 9 imaging imaging NN cord-339328-wizu3arz 99 10 equipment equipment NN cord-339328-wizu3arz 99 11 inside inside IN cord-339328-wizu3arz 99 12 the the DT cord-339328-wizu3arz 99 13 BSL-3/4 BSL-3/4 NNP cord-339328-wizu3arz 99 14 barrier barrier NN cord-339328-wizu3arz 99 15 ( ( -LRB- cord-339328-wizu3arz 99 16 e.g. e.g. RB cord-339328-wizu3arz 99 17 , , , cord-339328-wizu3arz 99 18 NIAID NIAID NNP cord-339328-wizu3arz 99 19 , , , cord-339328-wizu3arz 99 20 University University NNP cord-339328-wizu3arz 99 21 of of IN cord-339328-wizu3arz 99 22 Pittsburg Pittsburg NNP cord-339328-wizu3arz 99 23 ) ) -RRB- cord-339328-wizu3arz 99 24 . . . cord-339328-wizu3arz 100 1 While while IN cord-339328-wizu3arz 100 2 advantageous advantageous JJ cord-339328-wizu3arz 100 3 , , , cord-339328-wizu3arz 100 4 maintaining maintain VBG cord-339328-wizu3arz 100 5 expensive expensive JJ cord-339328-wizu3arz 100 6 equipment equipment NN cord-339328-wizu3arz 100 7 within within IN cord-339328-wizu3arz 100 8 these these DT cord-339328-wizu3arz 100 9 barriers barrier NNS cord-339328-wizu3arz 100 10 can can MD cord-339328-wizu3arz 100 11 be be VB cord-339328-wizu3arz 100 12 complicated complicated JJ cord-339328-wizu3arz 100 13 . . . cord-339328-wizu3arz 101 1 Therefore therefore RB cord-339328-wizu3arz 101 2 , , , cord-339328-wizu3arz 101 3 other other JJ cord-339328-wizu3arz 101 4 groups group NNS cord-339328-wizu3arz 101 5 have have VBP cord-339328-wizu3arz 101 6 utilized utilize VBN cord-339328-wizu3arz 101 7 animal animal NN cord-339328-wizu3arz 101 8 isolation isolation NN cord-339328-wizu3arz 101 9 approaches approach NNS cord-339328-wizu3arz 101 10 achieved achieve VBN cord-339328-wizu3arz 101 11 by by IN cord-339328-wizu3arz 101 12 isolating isolate VBG cord-339328-wizu3arz 101 13 infected infect VBN cord-339328-wizu3arz 101 14 - - HYPH cord-339328-wizu3arz 101 15 animals animal NNS cord-339328-wizu3arz 101 16 inside inside IN cord-339328-wizu3arz 101 17 sealed seal VBN cord-339328-wizu3arz 101 18 , , , cord-339328-wizu3arz 101 19 biocontainment biocontainment NN cord-339328-wizu3arz 101 20 devices device NNS cord-339328-wizu3arz 101 21 that that WDT cord-339328-wizu3arz 101 22 can can MD cord-339328-wizu3arz 101 23 be be VB cord-339328-wizu3arz 101 24 transported transport VBN cord-339328-wizu3arz 101 25 to to IN cord-339328-wizu3arz 101 26 the the DT cord-339328-wizu3arz 101 27 imaging imaging NN cord-339328-wizu3arz 101 28 equipment equipment NN cord-339328-wizu3arz 101 29 housed house VBN cord-339328-wizu3arz 101 30 in in IN cord-339328-wizu3arz 101 31 standard standard JJ cord-339328-wizu3arz 101 32 environments environment NNS cord-339328-wizu3arz 101 33 [ [ -LRB- cord-339328-wizu3arz 101 34 46 46 CD cord-339328-wizu3arz 101 35 , , , cord-339328-wizu3arz 101 36 51 51 CD cord-339328-wizu3arz 101 37 , , , cord-339328-wizu3arz 101 38 52 52 CD cord-339328-wizu3arz 101 39 ] ] -RRB- cord-339328-wizu3arz 101 40 or or CC cord-339328-wizu3arz 101 41 polycarbonate polycarbonate JJ cord-339328-wizu3arz 101 42 plastic plastic JJ cord-339328-wizu3arz 101 43 tubes tube NNS cord-339328-wizu3arz 101 44 extending extend VBG cord-339328-wizu3arz 101 45 from from IN cord-339328-wizu3arz 101 46 the the DT cord-339328-wizu3arz 101 47 biocontainment biocontainment NN cord-339328-wizu3arz 101 48 space space NN cord-339328-wizu3arz 101 49 to to IN cord-339328-wizu3arz 101 50 the the DT cord-339328-wizu3arz 101 51 imaging imaging NN cord-339328-wizu3arz 101 52 equipment equipment NN cord-339328-wizu3arz 101 53 [ [ -LRB- cord-339328-wizu3arz 101 54 53 53 CD cord-339328-wizu3arz 101 55 ] ] -RRB- cord-339328-wizu3arz 101 56 . . . cord-339328-wizu3arz 102 1 A a DT cord-339328-wizu3arz 102 2 tail tail NN cord-339328-wizu3arz 102 3 vein vein NN cord-339328-wizu3arz 102 4 catheter catheter NN cord-339328-wizu3arz 102 5 system system NN cord-339328-wizu3arz 102 6 was be VBD cord-339328-wizu3arz 102 7 also also RB cord-339328-wizu3arz 102 8 used use VBN cord-339328-wizu3arz 102 9 for for IN cord-339328-wizu3arz 102 10 on on IN cord-339328-wizu3arz 102 11 - - HYPH cord-339328-wizu3arz 102 12 table table NN cord-339328-wizu3arz 102 13 drug drug NN cord-339328-wizu3arz 102 14 delivery delivery NN cord-339328-wizu3arz 102 15 to to IN cord-339328-wizu3arz 102 16 infected infected JJ cord-339328-wizu3arz 102 17 animals animal NNS cord-339328-wizu3arz 102 18 while while IN cord-339328-wizu3arz 102 19 sealed seal VBN cord-339328-wizu3arz 102 20 inside inside IN cord-339328-wizu3arz 102 21 the the DT cord-339328-wizu3arz 102 22 biocontainment biocontainment NN cord-339328-wizu3arz 102 23 device device NN cord-339328-wizu3arz 102 24 [ [ -LRB- cord-339328-wizu3arz 102 25 24 24 CD cord-339328-wizu3arz 102 26 , , , cord-339328-wizu3arz 102 27 54 54 CD cord-339328-wizu3arz 102 28 ] ] -RRB- cord-339328-wizu3arz 102 29 . . . cord-339328-wizu3arz 103 1 Animal animal NN cord-339328-wizu3arz 103 2 containment containment NN cord-339328-wizu3arz 103 3 allows allow VBZ cord-339328-wizu3arz 103 4 for for IN cord-339328-wizu3arz 103 5 easier easy JJR cord-339328-wizu3arz 103 6 maintenance maintenance NN cord-339328-wizu3arz 103 7 of of IN cord-339328-wizu3arz 103 8 the the DT cord-339328-wizu3arz 103 9 equipment equipment NN cord-339328-wizu3arz 103 10 , , , cord-339328-wizu3arz 103 11 which which WDT cord-339328-wizu3arz 103 12 can can MD cord-339328-wizu3arz 103 13 also also RB cord-339328-wizu3arz 103 14 be be VB cord-339328-wizu3arz 103 15 shared share VBN cord-339328-wizu3arz 103 16 with with IN cord-339328-wizu3arz 103 17 other other JJ cord-339328-wizu3arz 103 18 investigators investigator NNS cord-339328-wizu3arz 103 19 that that WDT cord-339328-wizu3arz 103 20 do do VBP cord-339328-wizu3arz 103 21 not not RB cord-339328-wizu3arz 103 22 work work VB cord-339328-wizu3arz 103 23 within within IN cord-339328-wizu3arz 103 24 the the DT cord-339328-wizu3arz 103 25 BSL-3/4 BSL-3/4 NNP cord-339328-wizu3arz 103 26 barrier barrier NN cord-339328-wizu3arz 103 27 . . . cord-339328-wizu3arz 104 1 Unlike unlike IN cord-339328-wizu3arz 104 2 traditional traditional JJ cord-339328-wizu3arz 104 3 microbiological microbiological JJ cord-339328-wizu3arz 104 4 or or CC cord-339328-wizu3arz 104 5 molecular molecular JJ cord-339328-wizu3arz 104 6 techniques technique NNS cord-339328-wizu3arz 104 7 , , , cord-339328-wizu3arz 104 8 imaging imaging NN cord-339328-wizu3arz 104 9 can can MD cord-339328-wizu3arz 104 10 provide provide VB cord-339328-wizu3arz 104 11 key key JJ cord-339328-wizu3arz 104 12 spatial spatial JJ cord-339328-wizu3arz 104 13 information information NN cord-339328-wizu3arz 104 14 to to TO cord-339328-wizu3arz 104 15 dictate dictate VB cord-339328-wizu3arz 104 16 treatment treatment NN cord-339328-wizu3arz 104 17 , , , cord-339328-wizu3arz 104 18 enabling enable VBG cord-339328-wizu3arz 104 19 detection detection NN cord-339328-wizu3arz 104 20 and and CC cord-339328-wizu3arz 104 21 therapeutic therapeutic JJ cord-339328-wizu3arz 104 22 monitoring monitoring NN cord-339328-wizu3arz 104 23 of of IN cord-339328-wizu3arz 104 24 infections infection NNS cord-339328-wizu3arz 104 25 in in IN cord-339328-wizu3arz 104 26 patients patient NNS cord-339328-wizu3arz 104 27 with with IN cord-339328-wizu3arz 104 28 deep deep RB cord-339328-wizu3arz 104 29 - - HYPH cord-339328-wizu3arz 104 30 seated seat VBN cord-339328-wizu3arz 104 31 infections infection NNS cord-339328-wizu3arz 104 32 for for IN cord-339328-wizu3arz 104 33 whom whom WP cord-339328-wizu3arz 104 34 traditional traditional JJ cord-339328-wizu3arz 104 35 clinical clinical JJ cord-339328-wizu3arz 104 36 samples sample NNS cord-339328-wizu3arz 104 37 ( ( -LRB- cord-339328-wizu3arz 104 38 e.g. e.g. RB cord-339328-wizu3arz 104 39 , , , cord-339328-wizu3arz 104 40 blood blood NN cord-339328-wizu3arz 104 41 , , , cord-339328-wizu3arz 104 42 urine urine NN cord-339328-wizu3arz 104 43 ) ) -RRB- cord-339328-wizu3arz 104 44 would would MD cord-339328-wizu3arz 104 45 be be VB cord-339328-wizu3arz 104 46 insensitive insensitive JJ cord-339328-wizu3arz 104 47 and and CC cord-339328-wizu3arz 104 48 high high JJ cord-339328-wizu3arz 104 49 risk/ risk/ CD cord-339328-wizu3arz 104 50 impractical impractical JJ cord-339328-wizu3arz 104 51 ( ( -LRB- cord-339328-wizu3arz 104 52 e.g. e.g. RB cord-339328-wizu3arz 104 53 , , , cord-339328-wizu3arz 104 54 biopsy biopsy JJ cord-339328-wizu3arz 104 55 for for IN cord-339328-wizu3arz 104 56 brain brain NN cord-339328-wizu3arz 104 57 infection infection NN cord-339328-wizu3arz 104 58 ) ) -RRB- cord-339328-wizu3arz 104 59 or or CC cord-339328-wizu3arz 104 60 where where WRB cord-339328-wizu3arz 104 61 rapid rapid JJ cord-339328-wizu3arz 104 62 assessment assessment NN cord-339328-wizu3arz 104 63 of of IN cord-339328-wizu3arz 104 64 therapeutic therapeutic JJ cord-339328-wizu3arz 104 65 effect effect NN cord-339328-wizu3arz 104 66 is be VBZ cord-339328-wizu3arz 104 67 needed need VBN cord-339328-wizu3arz 104 68 . . . cord-339328-wizu3arz 105 1 In in IN cord-339328-wizu3arz 105 2 fact fact NN cord-339328-wizu3arz 105 3 , , , cord-339328-wizu3arz 105 4 in in IN cord-339328-wizu3arz 105 5 our -PRON- PRP$ cord-339328-wizu3arz 105 6 clinical clinical JJ cord-339328-wizu3arz 105 7 practice practice NN cord-339328-wizu3arz 105 8 at at IN cord-339328-wizu3arz 105 9 Johns Johns NNP cord-339328-wizu3arz 105 10 Hopkins Hopkins NNP cord-339328-wizu3arz 105 11 Hospital Hospital NNP cord-339328-wizu3arz 105 12 , , , cord-339328-wizu3arz 105 13 oncology oncology NN cord-339328-wizu3arz 105 14 patients patient NNS cord-339328-wizu3arz 105 15 with with IN cord-339328-wizu3arz 105 16 fever fever NN cord-339328-wizu3arz 105 17 and and CC cord-339328-wizu3arz 105 18 neutropenia neutropenia NN cord-339328-wizu3arz 105 19 or or CC cord-339328-wizu3arz 105 20 patients patient NNS cord-339328-wizu3arz 105 21 with with IN cord-339328-wizu3arz 105 22 fever fever NN cord-339328-wizu3arz 105 23 of of IN cord-339328-wizu3arz 105 24 unknown unknown JJ cord-339328-wizu3arz 105 25 origin origin NN cord-339328-wizu3arz 105 26 ( ( -LRB- cord-339328-wizu3arz 105 27 FUO fuo NN cord-339328-wizu3arz 105 28 ) ) -RRB- cord-339328-wizu3arz 105 29 routinely routinely RB cord-339328-wizu3arz 105 30 undergo undergo VBP cord-339328-wizu3arz 105 31 whole whole JJ cord-339328-wizu3arz 105 32 body body NN cord-339328-wizu3arz 105 33 imaging image VBG cord-339328-wizu3arz 105 34 to to TO cord-339328-wizu3arz 105 35 look look VB cord-339328-wizu3arz 105 36 for for IN cord-339328-wizu3arz 105 37 foci focus NNS cord-339328-wizu3arz 105 38 of of IN cord-339328-wizu3arz 105 39 Fig Fig NNP cord-339328-wizu3arz 105 40 . . . cord-339328-wizu3arz 106 1 2 2 LS cord-339328-wizu3arz 106 2 . . . cord-339328-wizu3arz 107 1 Relative relative JJ cord-339328-wizu3arz 107 2 risk risk NN cord-339328-wizu3arz 107 3 of of IN cord-339328-wizu3arz 107 4 infections infection NNS cord-339328-wizu3arz 107 5 with with IN cord-339328-wizu3arz 107 6 treatment treatment NN cord-339328-wizu3arz 107 7 - - HYPH cord-339328-wizu3arz 107 8 and and CC cord-339328-wizu3arz 107 9 radiation radiation NN cord-339328-wizu3arz 107 10 - - HYPH cord-339328-wizu3arz 107 11 induced induce VBN cord-339328-wizu3arz 107 12 cancer cancer NN cord-339328-wizu3arz 107 13 . . . cord-339328-wizu3arz 108 1 The the DT cord-339328-wizu3arz 108 2 risk risk NN cord-339328-wizu3arz 108 3 of of IN cord-339328-wizu3arz 108 4 mortality mortality NN cord-339328-wizu3arz 108 5 due due IN cord-339328-wizu3arz 108 6 to to IN cord-339328-wizu3arz 108 7 infections infection NNS cord-339328-wizu3arz 108 8 ( ( -LRB- cord-339328-wizu3arz 108 9 TB TB NNP cord-339328-wizu3arz 108 10 as as IN cord-339328-wizu3arz 108 11 an an DT cord-339328-wizu3arz 108 12 example example NN cord-339328-wizu3arz 108 13 ) ) -RRB- cord-339328-wizu3arz 108 14 compared compare VBN cord-339328-wizu3arz 108 15 to to IN cord-339328-wizu3arz 108 16 the the DT cord-339328-wizu3arz 108 17 risk risk NN cord-339328-wizu3arz 108 18 of of IN cord-339328-wizu3arz 108 19 radiation radiation NN cord-339328-wizu3arz 108 20 - - HYPH cord-339328-wizu3arz 108 21 induced induce VBN cord-339328-wizu3arz 108 22 cancer cancer NN cord-339328-wizu3arz 108 23 due due IN cord-339328-wizu3arz 108 24 to to IN cord-339328-wizu3arz 108 25 commonly commonly RB cord-339328-wizu3arz 108 26 used use VBN cord-339328-wizu3arz 108 27 imaging imaging NN cord-339328-wizu3arz 108 28 techniques technique NNS cord-339328-wizu3arz 108 29 . . . cord-339328-wizu3arz 109 1 The the DT cord-339328-wizu3arz 109 2 risk risk NN cord-339328-wizu3arz 109 3 of of IN cord-339328-wizu3arz 109 4 mortality mortality NN cord-339328-wizu3arz 109 5 for for IN cord-339328-wizu3arz 109 6 MDR MDR NNP cord-339328-wizu3arz 109 7 - - HYPH cord-339328-wizu3arz 109 8 and and CC cord-339328-wizu3arz 109 9 XDR XDR NNP cord-339328-wizu3arz 109 10 - - HYPH cord-339328-wizu3arz 109 11 TB TB NNP cord-339328-wizu3arz 109 12 patients patient NNS cord-339328-wizu3arz 109 13 on on IN cord-339328-wizu3arz 109 14 treatment treatment NN cord-339328-wizu3arz 109 15 is be VBZ cord-339328-wizu3arz 109 16 similar similar JJ cord-339328-wizu3arz 109 17 to to IN cord-339328-wizu3arz 109 18 that that DT cord-339328-wizu3arz 109 19 due due IN cord-339328-wizu3arz 109 20 to to IN cord-339328-wizu3arz 109 21 cancers cancer NNS cord-339328-wizu3arz 109 22 . . . cord-339328-wizu3arz 110 1 Even even RB cord-339328-wizu3arz 110 2 drug drug NN cord-339328-wizu3arz 110 3 - - HYPH cord-339328-wizu3arz 110 4 susceptible susceptible JJ cord-339328-wizu3arz 110 5 TB TB NNP cord-339328-wizu3arz 110 6 patients patient NNS cord-339328-wizu3arz 110 7 on on IN cord-339328-wizu3arz 110 8 treatment treatment NN cord-339328-wizu3arz 110 9 have have VBP cord-339328-wizu3arz 110 10 significantly significantly RB cord-339328-wizu3arz 110 11 higher high JJR cord-339328-wizu3arz 110 12 risk risk NN cord-339328-wizu3arz 110 13 of of IN cord-339328-wizu3arz 110 14 mortality mortality NN cord-339328-wizu3arz 110 15 than than IN cord-339328-wizu3arz 110 16 radiation radiation NN cord-339328-wizu3arz 110 17 - - HYPH cord-339328-wizu3arz 110 18 induced induce VBN cord-339328-wizu3arz 110 19 cancers cancer NNS cord-339328-wizu3arz 110 20 with with IN cord-339328-wizu3arz 110 21 optimized optimize VBN cord-339328-wizu3arz 110 22 imaging imaging NN cord-339328-wizu3arz 110 23 . . . cord-339328-wizu3arz 111 1 The the DT cord-339328-wizu3arz 111 2 risk risk NN cord-339328-wizu3arz 111 3 of of IN cord-339328-wizu3arz 111 4 radiation radiation NN cord-339328-wizu3arz 111 5 - - HYPH cord-339328-wizu3arz 111 6 induced induce VBN cord-339328-wizu3arz 111 7 cancer cancer NN cord-339328-wizu3arz 111 8 and and CC cord-339328-wizu3arz 111 9 mortality mortality NN cord-339328-wizu3arz 111 10 has have VBZ cord-339328-wizu3arz 111 11 been be VBN cord-339328-wizu3arz 111 12 theoretically theoretically RB cord-339328-wizu3arz 111 13 estimated estimate VBN cord-339328-wizu3arz 111 14 based base VBN cord-339328-wizu3arz 111 15 on on IN cord-339328-wizu3arz 111 16 acute acute JJ cord-339328-wizu3arz 111 17 radiation radiation NN cord-339328-wizu3arz 111 18 exposure exposure NN cord-339328-wizu3arz 111 19 ( ( -LRB- cord-339328-wizu3arz 111 20 100 100 CD cord-339328-wizu3arz 111 21 mSv mSv NNP cord-339328-wizu3arz 111 22 ) ) -RRB- cord-339328-wizu3arz 111 23 , , , cord-339328-wizu3arz 111 24 and and CC cord-339328-wizu3arz 111 25 actual actual JJ cord-339328-wizu3arz 111 26 risks risk NNS cord-339328-wizu3arz 111 27 are be VBP cord-339328-wizu3arz 111 28 likely likely JJ cord-339328-wizu3arz 111 29 to to TO cord-339328-wizu3arz 111 30 be be VB cord-339328-wizu3arz 111 31 much much RB cord-339328-wizu3arz 111 32 lower low JJR cord-339328-wizu3arz 111 33 for for IN cord-339328-wizu3arz 111 34 smaller small JJR cord-339328-wizu3arz 111 35 amounts amount NNS cord-339328-wizu3arz 111 36 of of IN cord-339328-wizu3arz 111 37 radiation radiation NN cord-339328-wizu3arz 111 38 . . . cord-339328-wizu3arz 112 1 infection infection NN cord-339328-wizu3arz 112 2 . . . cord-339328-wizu3arz 113 1 However however RB cord-339328-wizu3arz 113 2 , , , cord-339328-wizu3arz 113 3 current current JJ cord-339328-wizu3arz 113 4 imaging imaging NN cord-339328-wizu3arz 113 5 modalities modality NNS cord-339328-wizu3arz 113 6 are be VBP cord-339328-wizu3arz 113 7 not not RB cord-339328-wizu3arz 113 8 specific specific JJ cord-339328-wizu3arz 113 9 , , , cord-339328-wizu3arz 113 10 and and CC cord-339328-wizu3arz 113 11 biopsies biopsy NNS cord-339328-wizu3arz 113 12 are be VBP cord-339328-wizu3arz 113 13 often often RB cord-339328-wizu3arz 113 14 non non JJ cord-339328-wizu3arz 113 15 - - JJ cord-339328-wizu3arz 113 16 diagnostic diagnostic JJ cord-339328-wizu3arz 113 17 , , , cord-339328-wizu3arz 113 18 leading lead VBG cord-339328-wizu3arz 113 19 to to IN cord-339328-wizu3arz 113 20 uncertainty uncertainty NN cord-339328-wizu3arz 113 21 and and CC cord-339328-wizu3arz 113 22 overuse overuse NN cord-339328-wizu3arz 113 23 ( ( -LRB- cord-339328-wizu3arz 113 24 or or CC cord-339328-wizu3arz 113 25 misuse misuse JJ cord-339328-wizu3arz 113 26 ) ) -RRB- cord-339328-wizu3arz 113 27 of of IN cord-339328-wizu3arz 113 28 broad broad JJ cord-339328-wizu3arz 113 29 - - HYPH cord-339328-wizu3arz 113 30 spectrum spectrum NN cord-339328-wizu3arz 113 31 antimicrobials antimicrobial NNS cord-339328-wizu3arz 113 32 . . . cord-339328-wizu3arz 114 1 CT CT NNP cord-339328-wizu3arz 114 2 and and CC cord-339328-wizu3arz 114 3 other other JJ cord-339328-wizu3arz 114 4 nuclear nuclear JJ cord-339328-wizu3arz 114 5 medicine medicine NN cord-339328-wizu3arz 114 6 techniques technique NNS cord-339328-wizu3arz 114 7 are be VBP cord-339328-wizu3arz 114 8 often often RB cord-339328-wizu3arz 114 9 perceived perceive VBN cord-339328-wizu3arz 114 10 to to TO cord-339328-wizu3arz 114 11 deliver deliver VB cord-339328-wizu3arz 114 12 high high JJ cord-339328-wizu3arz 114 13 levels level NNS cord-339328-wizu3arz 114 14 of of IN cord-339328-wizu3arz 114 15 radiation radiation NN cord-339328-wizu3arz 114 16 . . . cord-339328-wizu3arz 115 1 However however RB cord-339328-wizu3arz 115 2 , , , cord-339328-wizu3arz 115 3 recent recent JJ cord-339328-wizu3arz 115 4 technological technological JJ cord-339328-wizu3arz 115 5 developments development NNS cord-339328-wizu3arz 115 6 have have VBP cord-339328-wizu3arz 115 7 significantly significantly RB cord-339328-wizu3arz 115 8 lowered lower VBN cord-339328-wizu3arz 115 9 radiation radiation NN cord-339328-wizu3arz 115 10 exposure exposure NN cord-339328-wizu3arz 115 11 and and CC cord-339328-wizu3arz 115 12 also also RB cord-339328-wizu3arz 115 13 allowed allow VBD cord-339328-wizu3arz 115 14 rapid rapid JJ cord-339328-wizu3arz 115 15 scans scan NNS cord-339328-wizu3arz 115 16 that that WDT cord-339328-wizu3arz 115 17 avoids avoid VBZ cord-339328-wizu3arz 115 18 the the DT cord-339328-wizu3arz 115 19 need need NN cord-339328-wizu3arz 115 20 for for IN cord-339328-wizu3arz 115 21 sedation sedation NN cord-339328-wizu3arz 115 22 in in IN cord-339328-wizu3arz 115 23 children child NNS cord-339328-wizu3arz 115 24 . . . cord-339328-wizu3arz 116 1 For for IN cord-339328-wizu3arz 116 2 example example NN cord-339328-wizu3arz 116 3 , , , cord-339328-wizu3arz 116 4 the the DT cord-339328-wizu3arz 116 5 effective effective JJ cord-339328-wizu3arz 116 6 dose dose NN cord-339328-wizu3arz 116 7 for for IN cord-339328-wizu3arz 116 8 each each DT cord-339328-wizu3arz 116 9 chest chest NN cord-339328-wizu3arz 116 10 CT CT NNP cord-339328-wizu3arz 116 11 in in IN cord-339328-wizu3arz 116 12 the the DT cord-339328-wizu3arz 116 13 child child NN cord-339328-wizu3arz 116 14 treated treat VBN cord-339328-wizu3arz 116 15 for for IN cord-339328-wizu3arz 116 16 XDR XDR NNP cord-339328-wizu3arz 116 17 - - HYPH cord-339328-wizu3arz 116 18 TB TB NNP cord-339328-wizu3arz 116 19 was be VBD cord-339328-wizu3arz 116 20 0.4 0.4 CD cord-339328-wizu3arz 116 21 - - SYM cord-339328-wizu3arz 116 22 0.7 0.7 CD cord-339328-wizu3arz 116 23 mSv mSv NNP cord-339328-wizu3arz 116 24 [ [ -LRB- cord-339328-wizu3arz 116 25 9 9 CD cord-339328-wizu3arz 116 26 ] ] -RRB- cord-339328-wizu3arz 116 27 . . . cord-339328-wizu3arz 117 1 This this DT cord-339328-wizu3arz 117 2 is be VBZ cord-339328-wizu3arz 117 3 equivalent equivalent JJ cord-339328-wizu3arz 117 4 to to IN cord-339328-wizu3arz 117 5 3 3 CD cord-339328-wizu3arz 117 6 months month NNS cord-339328-wizu3arz 117 7 of of IN cord-339328-wizu3arz 117 8 natural natural JJ cord-339328-wizu3arz 117 9 background background NN cord-339328-wizu3arz 117 10 radiation radiation NN cord-339328-wizu3arz 117 11 , , , cord-339328-wizu3arz 117 12 a a DT cord-339328-wizu3arz 117 13 single single JJ cord-339328-wizu3arz 117 14 screening screening NN cord-339328-wizu3arz 117 15 mammography mammography NN cord-339328-wizu3arz 117 16 , , , cord-339328-wizu3arz 117 17 or or CC cord-339328-wizu3arz 117 18 four four CD cord-339328-wizu3arz 117 19 trans trans JJ cord-339328-wizu3arz 117 20 - - JJ cord-339328-wizu3arz 117 21 Atlantic atlantic JJ cord-339328-wizu3arz 117 22 airplane airplane NN cord-339328-wizu3arz 117 23 round round NN cord-339328-wizu3arz 117 24 trips trip NNS cord-339328-wizu3arz 117 25 [ [ -LRB- cord-339328-wizu3arz 117 26 55 55 CD cord-339328-wizu3arz 117 27 ] ] -RRB- cord-339328-wizu3arz 117 28 [ [ -LRB- cord-339328-wizu3arz 117 29 56 56 CD cord-339328-wizu3arz 117 30 ] ] -RRB- cord-339328-wizu3arz 117 31 [ [ -LRB- cord-339328-wizu3arz 117 32 57 57 CD cord-339328-wizu3arz 117 33 ] ] -RRB- cord-339328-wizu3arz 117 34 . . . cord-339328-wizu3arz 118 1 Moreover moreover RB cord-339328-wizu3arz 118 2 , , , cord-339328-wizu3arz 118 3 no no DT cord-339328-wizu3arz 118 4 sedation sedation NN cord-339328-wizu3arz 118 5 was be VBD cord-339328-wizu3arz 118 6 required require VBN cord-339328-wizu3arz 118 7 for for IN cord-339328-wizu3arz 118 8 this this DT cord-339328-wizu3arz 118 9 child child NN cord-339328-wizu3arz 118 10 as as IN cord-339328-wizu3arz 118 11 scan scan JJ cord-339328-wizu3arz 118 12 times time NNS cord-339328-wizu3arz 118 13 were be VBD cord-339328-wizu3arz 118 14 short short JJ cord-339328-wizu3arz 118 15 ( ( -LRB- cord-339328-wizu3arz 118 16 3 3 CD cord-339328-wizu3arz 118 17 s s NN cord-339328-wizu3arz 118 18 ) ) -RRB- cord-339328-wizu3arz 118 19 . . . cord-339328-wizu3arz 119 1 We -PRON- PRP cord-339328-wizu3arz 119 2 calculated calculate VBD cord-339328-wizu3arz 119 3 the the DT cord-339328-wizu3arz 119 4 risks risk NNS cord-339328-wizu3arz 119 5 related relate VBN cord-339328-wizu3arz 119 6 to to IN cord-339328-wizu3arz 119 7 infections infection NNS cord-339328-wizu3arz 119 8 , , , cord-339328-wizu3arz 119 9 with with IN cord-339328-wizu3arz 119 10 TB TB NNP cord-339328-wizu3arz 119 11 as as IN cord-339328-wizu3arz 119 12 an an DT cord-339328-wizu3arz 119 13 example example NN cord-339328-wizu3arz 119 14 , , , cord-339328-wizu3arz 119 15 and and CC cord-339328-wizu3arz 119 16 compared compare VBD cord-339328-wizu3arz 119 17 them -PRON- PRP cord-339328-wizu3arz 119 18 to to IN cord-339328-wizu3arz 119 19 the the DT cord-339328-wizu3arz 119 20 various various JJ cord-339328-wizu3arz 119 21 imaging imaging NN cord-339328-wizu3arz 119 22 techniques technique NNS cord-339328-wizu3arz 119 23 used use VBN cord-339328-wizu3arz 119 24 currently currently RB cord-339328-wizu3arz 119 25 ( ( -LRB- cord-339328-wizu3arz 119 26 Fig Fig NNP cord-339328-wizu3arz 119 27 . . NNP cord-339328-wizu3arz 119 28 2 2 CD cord-339328-wizu3arz 119 29 ) ) -RRB- cord-339328-wizu3arz 119 30 . . . cord-339328-wizu3arz 120 1 The the DT cord-339328-wizu3arz 120 2 risk risk NN cord-339328-wizu3arz 120 3 of of IN cord-339328-wizu3arz 120 4 mortality mortality NN cord-339328-wizu3arz 120 5 for for IN cord-339328-wizu3arz 120 6 patients patient NNS cord-339328-wizu3arz 120 7 with with IN cord-339328-wizu3arz 120 8 MDR MDR NNP cord-339328-wizu3arz 120 9 - - HYPH cord-339328-wizu3arz 120 10 and and CC cord-339328-wizu3arz 120 11 XDR XDR NNP cord-339328-wizu3arz 120 12 - - HYPH cord-339328-wizu3arz 120 13 TB TB NNP cord-339328-wizu3arz 120 14 on on IN cord-339328-wizu3arz 120 15 treatment treatment NN cord-339328-wizu3arz 120 16 is be VBZ cord-339328-wizu3arz 120 17 similar similar JJ cord-339328-wizu3arz 120 18 to to IN cord-339328-wizu3arz 120 19 that that DT cord-339328-wizu3arz 120 20 due due IN cord-339328-wizu3arz 120 21 to to IN cord-339328-wizu3arz 120 22 cancers cancer NNS cord-339328-wizu3arz 120 23 [ [ -LRB- cord-339328-wizu3arz 120 24 8 8 CD cord-339328-wizu3arz 120 25 , , , cord-339328-wizu3arz 120 26 52 52 CD cord-339328-wizu3arz 120 27 , , , cord-339328-wizu3arz 120 28 58 58 CD cord-339328-wizu3arz 120 29 ] ] -RRB- cord-339328-wizu3arz 120 30 . . . cord-339328-wizu3arz 121 1 Moreover moreover RB cord-339328-wizu3arz 121 2 , , , cord-339328-wizu3arz 121 3 even even RB cord-339328-wizu3arz 121 4 patients patient NNS cord-339328-wizu3arz 121 5 with with IN cord-339328-wizu3arz 121 6 drugsusceptible drugsusceptible JJ cord-339328-wizu3arz 121 7 TB TB NNP cord-339328-wizu3arz 121 8 on on IN cord-339328-wizu3arz 121 9 treatment treatment NN cord-339328-wizu3arz 121 10 have have VBP cord-339328-wizu3arz 121 11 several several JJ cord-339328-wizu3arz 121 12 orders order NNS cord-339328-wizu3arz 121 13 of of IN cord-339328-wizu3arz 121 14 magnitude magnitude NN cord-339328-wizu3arz 121 15 higher high JJR cord-339328-wizu3arz 121 16 risk risk NN cord-339328-wizu3arz 121 17 of of IN cord-339328-wizu3arz 121 18 mortality mortality NN cord-339328-wizu3arz 121 19 than than IN cord-339328-wizu3arz 121 20 the the DT cord-339328-wizu3arz 121 21 theoretical theoretical JJ cord-339328-wizu3arz 121 22 risk risk NN cord-339328-wizu3arz 121 23 due due JJ cord-339328-wizu3arz 121 24 to to IN cord-339328-wizu3arz 121 25 radiationinduced radiationinduced JJ cord-339328-wizu3arz 121 26 cancers cancer NNS cord-339328-wizu3arz 121 27 [ [ -LRB- cord-339328-wizu3arz 121 28 59 59 CD cord-339328-wizu3arz 121 29 , , , cord-339328-wizu3arz 121 30 60 60 CD cord-339328-wizu3arz 121 31 ] ] -RRB- cord-339328-wizu3arz 121 32 . . . cord-339328-wizu3arz 122 1 Development development NN cord-339328-wizu3arz 122 2 of of IN cord-339328-wizu3arz 122 3 nuclear nuclear JJ cord-339328-wizu3arz 122 4 imaging imaging NN cord-339328-wizu3arz 122 5 tracers tracer NNS cord-339328-wizu3arz 122 6 with with IN cord-339328-wizu3arz 122 7 short short JJ cord-339328-wizu3arz 122 8 half half JJ cord-339328-wizu3arz 122 9 - - HYPH cord-339328-wizu3arz 122 10 life life NN cord-339328-wizu3arz 122 11 isotopes isotope NNS cord-339328-wizu3arz 122 12 and and CC cord-339328-wizu3arz 122 13 rapid rapid JJ cord-339328-wizu3arz 122 14 elimination elimination NN cord-339328-wizu3arz 122 15 from from IN cord-339328-wizu3arz 122 16 the the DT cord-339328-wizu3arz 122 17 body body NN cord-339328-wizu3arz 122 18 could could MD cord-339328-wizu3arz 122 19 further far RBR cord-339328-wizu3arz 122 20 limit limit VB cord-339328-wizu3arz 122 21 radiation radiation NN cord-339328-wizu3arz 122 22 exposure exposure NN cord-339328-wizu3arz 122 23 . . . cord-339328-wizu3arz 123 1 While while IN cord-339328-wizu3arz 123 2 no no DT cord-339328-wizu3arz 123 3 studies study NNS cord-339328-wizu3arz 123 4 should should MD cord-339328-wizu3arz 123 5 be be VB cord-339328-wizu3arz 123 6 performed perform VBN cord-339328-wizu3arz 123 7 without without IN cord-339328-wizu3arz 123 8 an an DT cord-339328-wizu3arz 123 9 excellent excellent JJ cord-339328-wizu3arz 123 10 rationale rationale NN cord-339328-wizu3arz 123 11 and and CC cord-339328-wizu3arz 123 12 clinical clinical JJ cord-339328-wizu3arz 123 13 indication indication NN cord-339328-wizu3arz 123 14 , , , cord-339328-wizu3arz 123 15 we -PRON- PRP cord-339328-wizu3arz 123 16 need need VBP cord-339328-wizu3arz 123 17 to to TO cord-339328-wizu3arz 123 18 be be VB cord-339328-wizu3arz 123 19 pragmatic pragmatic JJ cord-339328-wizu3arz 123 20 about about IN cord-339328-wizu3arz 123 21 the the DT cord-339328-wizu3arz 123 22 ( ( -LRB- cord-339328-wizu3arz 123 23 minimal minimal JJ cord-339328-wizu3arz 123 24 ) ) -RRB- cord-339328-wizu3arz 123 25 risks risk NNS cord-339328-wizu3arz 123 26 of of IN cord-339328-wizu3arz 123 27 imaging imaging NN cord-339328-wizu3arz 123 28 , , , cord-339328-wizu3arz 123 29 especially especially RB cord-339328-wizu3arz 123 30 when when WRB cord-339328-wizu3arz 123 31 dealing deal VBG cord-339328-wizu3arz 123 32 with with IN cord-339328-wizu3arz 123 33 infections infection NNS cord-339328-wizu3arz 123 34 due due JJ cord-339328-wizu3arz 123 35 to to IN cord-339328-wizu3arz 123 36 MDR MDR NNP cord-339328-wizu3arz 123 37 organisms organism NNS cord-339328-wizu3arz 123 38 . . . cord-339328-wizu3arz 124 1 Given give VBN cord-339328-wizu3arz 124 2 sub sub JJ cord-339328-wizu3arz 124 3 - - JJ cord-339328-wizu3arz 124 4 pharmacological pharmacological JJ cord-339328-wizu3arz 124 5 dosing dosing NN cord-339328-wizu3arz 124 6 , , , cord-339328-wizu3arz 124 7 there there EX cord-339328-wizu3arz 124 8 are be VBP cord-339328-wizu3arz 124 9 several several JJ cord-339328-wizu3arz 124 10 approaches approach NNS cord-339328-wizu3arz 124 11 for for IN cord-339328-wizu3arz 124 12 translating translate VBG cord-339328-wizu3arz 124 13 PET pet JJ cord-339328-wizu3arz 124 14 tracers tracer NNS cord-339328-wizu3arz 124 15 to to IN cord-339328-wizu3arz 124 16 humans human NNS cord-339328-wizu3arz 124 17 [ [ -LRB- cord-339328-wizu3arz 124 18 61 61 CD cord-339328-wizu3arz 124 19 ] ] -RRB- cord-339328-wizu3arz 124 20 , , , cord-339328-wizu3arz 124 21 allowing allow VBG cord-339328-wizu3arz 124 22 more more RBR cord-339328-wizu3arz 124 23 rapid rapid JJ cord-339328-wizu3arz 124 24 translation translation NN cord-339328-wizu3arz 124 25 of of IN cord-339328-wizu3arz 124 26 new new JJ cord-339328-wizu3arz 124 27 imaging imaging NN cord-339328-wizu3arz 124 28 tools tool NNS cord-339328-wizu3arz 124 29 to to IN cord-339328-wizu3arz 124 30 the the DT cord-339328-wizu3arz 124 31 clinic clinic NN cord-339328-wizu3arz 124 32 . . . cord-339328-wizu3arz 125 1 Some some DT cord-339328-wizu3arz 125 2 PET pet NN cord-339328-wizu3arz 125 3 tracers tracer NNS cord-339328-wizu3arz 125 4 discussed discuss VBN cord-339328-wizu3arz 125 5 above above RB cord-339328-wizu3arz 125 6 are be VBP cord-339328-wizu3arz 125 7 currently currently RB cord-339328-wizu3arz 125 8 being be VBG cord-339328-wizu3arz 125 9 tested test VBN cord-339328-wizu3arz 125 10 in in IN cord-339328-wizu3arz 125 11 humans human NNS cord-339328-wizu3arz 125 12 . . . cord-339328-wizu3arz 126 1 Recently recently RB cord-339328-wizu3arz 126 2 , , , cord-339328-wizu3arz 126 3 a a DT cord-339328-wizu3arz 126 4 study study NN cord-339328-wizu3arz 126 5 in in IN cord-339328-wizu3arz 126 6 healthy healthy JJ cord-339328-wizu3arz 126 7 volunteers volunteer NNS cord-339328-wizu3arz 126 8 demonstrated demonstrate VBD cord-339328-wizu3arz 126 9 that that IN cord-339328-wizu3arz 126 10 18 18 CD cord-339328-wizu3arz 126 11 F F NNP cord-339328-wizu3arz 126 12 - - HYPH cord-339328-wizu3arz 126 13 FDS FDS NNP cord-339328-wizu3arz 126 14 was be VBD cord-339328-wizu3arz 126 15 safe safe JJ cord-339328-wizu3arz 126 16 , , , cord-339328-wizu3arz 126 17 well well RB cord-339328-wizu3arz 126 18 tolerated tolerate VBN cord-339328-wizu3arz 126 19 , , , cord-339328-wizu3arz 126 20 and and CC cord-339328-wizu3arz 126 21 rapidly rapidly RB cord-339328-wizu3arz 126 22 cleared clear VBN cord-339328-wizu3arz 126 23 , , , cord-339328-wizu3arz 126 24 following follow VBG cord-339328-wizu3arz 126 25 a a DT cord-339328-wizu3arz 126 26 single single JJ cord-339328-wizu3arz 126 27 , , , cord-339328-wizu3arz 126 28 intravenous intravenous JJ cord-339328-wizu3arz 126 29 dose dose NN cord-339328-wizu3arz 126 30 [ [ -LRB- cord-339328-wizu3arz 126 31 62 62 CD cord-339328-wizu3arz 126 32 ] ] -RRB- cord-339328-wizu3arz 126 33 , , , cord-339328-wizu3arz 126 34 suggesting suggest VBG cord-339328-wizu3arz 126 35 significant significant JJ cord-339328-wizu3arz 126 36 potential potential NN cord-339328-wizu3arz 126 37 for for IN cord-339328-wizu3arz 126 38 use use NN cord-339328-wizu3arz 126 39 in in IN cord-339328-wizu3arz 126 40 humans human NNS cord-339328-wizu3arz 126 41 . . . cord-339328-wizu3arz 127 1 During during IN cord-339328-wizu3arz 127 2 the the DT cord-339328-wizu3arz 127 3 past past JJ cord-339328-wizu3arz 127 4 decade decade NN cord-339328-wizu3arz 127 5 , , , cord-339328-wizu3arz 127 6 developing develop VBG cord-339328-wizu3arz 127 7 countries country NNS cord-339328-wizu3arz 127 8 , , , cord-339328-wizu3arz 127 9 especially especially RB cord-339328-wizu3arz 127 10 the the DT cord-339328-wizu3arz 127 11 BRICS BRICS NNP cord-339328-wizu3arz 127 12 nations nation NNS cord-339328-wizu3arz 127 13 ( ( -LRB- cord-339328-wizu3arz 127 14 Brazil Brazil NNP cord-339328-wizu3arz 127 15 , , , cord-339328-wizu3arz 127 16 Russia Russia NNP cord-339328-wizu3arz 127 17 , , , cord-339328-wizu3arz 127 18 India India NNP cord-339328-wizu3arz 127 19 , , , cord-339328-wizu3arz 127 20 China China NNP cord-339328-wizu3arz 127 21 , , , cord-339328-wizu3arz 127 22 South South NNP cord-339328-wizu3arz 127 23 Africa Africa NNP cord-339328-wizu3arz 127 24 ) ) -RRB- cord-339328-wizu3arz 127 25 , , , cord-339328-wizu3arz 127 26 have have VBP cord-339328-wizu3arz 127 27 witnessed witness VBN cord-339328-wizu3arz 127 28 significant significant JJ cord-339328-wizu3arz 127 29 increases increase NNS cord-339328-wizu3arz 127 30 in in IN cord-339328-wizu3arz 127 31 the the DT cord-339328-wizu3arz 127 32 installation installation NN cord-339328-wizu3arz 127 33 and and CC cord-339328-wizu3arz 127 34 use use NN cord-339328-wizu3arz 127 35 of of IN cord-339328-wizu3arz 127 36 advanced advanced JJ cord-339328-wizu3arz 127 37 imaging imaging NN cord-339328-wizu3arz 127 38 . . . cord-339328-wizu3arz 128 1 For for IN cord-339328-wizu3arz 128 2 example example NN cord-339328-wizu3arz 128 3 , , , cord-339328-wizu3arz 128 4 New New NNP cord-339328-wizu3arz 128 5 Delhi Delhi NNP cord-339328-wizu3arz 128 6 ( ( -LRB- cord-339328-wizu3arz 128 7 India India NNP cord-339328-wizu3arz 128 8 ) ) -RRB- cord-339328-wizu3arz 128 9 alone alone RB cord-339328-wizu3arz 128 10 has have VBZ cord-339328-wizu3arz 128 11 9100 9100 CD cord-339328-wizu3arz 128 12 clinical clinical JJ cord-339328-wizu3arz 128 13 MRI MRI NNP cord-339328-wizu3arz 128 14 scanners scanner NNS cord-339328-wizu3arz 128 15 ( ( -LRB- cord-339328-wizu3arz 128 16 several several JJ cord-339328-wizu3arz 128 17 with with IN cord-339328-wizu3arz 128 18 3 3 CD cord-339328-wizu3arz 128 19 T t NN cord-339328-wizu3arz 128 20 strength strength NN cord-339328-wizu3arz 128 21 ) ) -RRB- cord-339328-wizu3arz 128 22 [ [ -LRB- cord-339328-wizu3arz 128 23 63 63 CD cord-339328-wizu3arz 128 24 , , , cord-339328-wizu3arz 128 25 64 64 CD cord-339328-wizu3arz 128 26 ] ] -RRB- cord-339328-wizu3arz 128 27 . . . cord-339328-wizu3arz 129 1 Moreover moreover RB cord-339328-wizu3arz 129 2 , , , cord-339328-wizu3arz 129 3 CT CT NNP cord-339328-wizu3arz 129 4 , , , cord-339328-wizu3arz 129 5 MRI MRI NNP cord-339328-wizu3arz 129 6 , , , cord-339328-wizu3arz 129 7 and and CC cord-339328-wizu3arz 129 8 PET PET NNP cord-339328-wizu3arz 129 9 / / SYM cord-339328-wizu3arz 129 10 CT CT NNP cord-339328-wizu3arz 129 11 costs cost NNS cord-339328-wizu3arz 129 12 are be VBP cord-339328-wizu3arz 129 13 substantially substantially RB cord-339328-wizu3arz 129 14 lower,~$50-$100 lower,~$50-$100 VBN cord-339328-wizu3arz 129 15 for for IN cord-339328-wizu3arz 129 16 CT CT NNP cord-339328-wizu3arz 129 17 and and CC cord-339328-wizu3arz 129 18 MRI MRI NNP cord-339328-wizu3arz 129 19 and and CC cord-339328-wizu3arz 129 20 $ $ $ cord-339328-wizu3arz 129 21 300 300 CD cord-339328-wizu3arz 129 22 for for IN cord-339328-wizu3arz 129 23 PET pet NN cord-339328-wizu3arz 129 24 per per IN cord-339328-wizu3arz 129 25 scan scan NN cord-339328-wizu3arz 129 26 at at IN cord-339328-wizu3arz 129 27 private private JJ cord-339328-wizu3arz 129 28 ( ( -LRB- cord-339328-wizu3arz 129 29 for for IN cord-339328-wizu3arz 129 30 - - HYPH cord-339328-wizu3arz 129 31 profit profit NN cord-339328-wizu3arz 129 32 centers center NNS cord-339328-wizu3arz 129 33 ) ) -RRB- cord-339328-wizu3arz 129 34 in in IN cord-339328-wizu3arz 129 35 developing develop VBG cord-339328-wizu3arz 129 36 nations nation NNS cord-339328-wizu3arz 129 37 such such JJ cord-339328-wizu3arz 129 38 as as IN cord-339328-wizu3arz 129 39 India India NNP cord-339328-wizu3arz 129 40 than than IN cord-339328-wizu3arz 129 41 in in IN cord-339328-wizu3arz 129 42 the the DT cord-339328-wizu3arz 129 43 USA USA NNP cord-339328-wizu3arz 129 44 [ [ -LRB- cord-339328-wizu3arz 129 45 53 53 CD cord-339328-wizu3arz 129 46 ] ] -RRB- cord-339328-wizu3arz 129 47 . . . cord-339328-wizu3arz 130 1 Mobile Mobile NNP cord-339328-wizu3arz 130 2 PET PET NNP cord-339328-wizu3arz 130 3 scanners scanner NNS cord-339328-wizu3arz 130 4 and and CC cord-339328-wizu3arz 130 5 68 68 CD cord-339328-wizu3arz 130 6 Ga Ga NNP cord-339328-wizu3arz 130 7 PET PET NNP cord-339328-wizu3arz 130 8 agents agent NNS cord-339328-wizu3arz 130 9 that that WDT cord-339328-wizu3arz 130 10 can can MD cord-339328-wizu3arz 130 11 be be VB cord-339328-wizu3arz 130 12 generated generate VBN cord-339328-wizu3arz 130 13 without without IN cord-339328-wizu3arz 130 14 the the DT cord-339328-wizu3arz 130 15 need need NN cord-339328-wizu3arz 130 16 of of IN cord-339328-wizu3arz 130 17 a a DT cord-339328-wizu3arz 130 18 cyclotron cyclotron NN cord-339328-wizu3arz 130 19 hold hold NN cord-339328-wizu3arz 130 20 great great JJ cord-339328-wizu3arz 130 21 promise promise NN cord-339328-wizu3arz 130 22 for for IN cord-339328-wizu3arz 130 23 use use NN cord-339328-wizu3arz 130 24 in in IN cord-339328-wizu3arz 130 25 remote remote JJ cord-339328-wizu3arz 130 26 areas area NNS cord-339328-wizu3arz 130 27 [ [ -LRB- cord-339328-wizu3arz 130 28 29 29 CD cord-339328-wizu3arz 130 29 ] ] -RRB- cord-339328-wizu3arz 130 30 . . . cord-339328-wizu3arz 131 1 China China NNP cord-339328-wizu3arz 131 2 has have VBZ cord-339328-wizu3arz 131 3 already already RB cord-339328-wizu3arz 131 4 overtaken overtake VBN cord-339328-wizu3arz 131 5 the the DT cord-339328-wizu3arz 131 6 USA USA NNP cord-339328-wizu3arz 131 7 to to TO cord-339328-wizu3arz 131 8 become become VB cord-339328-wizu3arz 131 9 the the DT cord-339328-wizu3arz 131 10 largest large JJS cord-339328-wizu3arz 131 11 economy economy NN cord-339328-wizu3arz 131 12 in in IN cord-339328-wizu3arz 131 13 purchasing purchase VBG cord-339328-wizu3arz 131 14 power power NN cord-339328-wizu3arz 131 15 parity parity NN cord-339328-wizu3arz 131 16 , , , cord-339328-wizu3arz 131 17 with with IN cord-339328-wizu3arz 131 18 India India NNP cord-339328-wizu3arz 131 19 expected expect VBD cord-339328-wizu3arz 131 20 to to TO cord-339328-wizu3arz 131 21 become become VB cord-339328-wizu3arz 131 22 the the DT cord-339328-wizu3arz 131 23 second second RB cord-339328-wizu3arz 131 24 largest large JJS cord-339328-wizu3arz 131 25 economy economy NN cord-339328-wizu3arz 131 26 in in IN cord-339328-wizu3arz 131 27 purchasing purchase VBG cord-339328-wizu3arz 131 28 power power NN cord-339328-wizu3arz 131 29 parity parity NN cord-339328-wizu3arz 131 30 by by IN cord-339328-wizu3arz 131 31 2050 2050 CD cord-339328-wizu3arz 131 32 [ [ -LRB- cord-339328-wizu3arz 131 33 65 65 CD cord-339328-wizu3arz 131 34 ] ] -RRB- cord-339328-wizu3arz 131 35 . . . cord-339328-wizu3arz 132 1 Infections infection NNS cord-339328-wizu3arz 132 2 are be VBP cord-339328-wizu3arz 132 3 rampant rampant JJ cord-339328-wizu3arz 132 4 in in IN cord-339328-wizu3arz 132 5 the the DT cord-339328-wizu3arz 132 6 developing develop VBG cord-339328-wizu3arz 132 7 world world NN cord-339328-wizu3arz 132 8 , , , cord-339328-wizu3arz 132 9 and and CC cord-339328-wizu3arz 132 10 given give VBN cord-339328-wizu3arz 132 11 the the DT cord-339328-wizu3arz 132 12 considerable considerable JJ cord-339328-wizu3arz 132 13 number number NN cord-339328-wizu3arz 132 14 of of IN cord-339328-wizu3arz 132 15 people people NNS cord-339328-wizu3arz 132 16 living live VBG cord-339328-wizu3arz 132 17 in in IN cord-339328-wizu3arz 132 18 big big JJ cord-339328-wizu3arz 132 19 cities city NNS cord-339328-wizu3arz 132 20 , , , cord-339328-wizu3arz 132 21 advanced advanced JJ cord-339328-wizu3arz 132 22 imaging imaging NN cord-339328-wizu3arz 132 23 has have VBZ cord-339328-wizu3arz 132 24 the the DT cord-339328-wizu3arz 132 25 potential potential NN cord-339328-wizu3arz 132 26 to to TO cord-339328-wizu3arz 132 27 become become VB cord-339328-wizu3arz 132 28 a a DT cord-339328-wizu3arz 132 29 powerful powerful JJ cord-339328-wizu3arz 132 30 routine routine JJ cord-339328-wizu3arz 132 31 clinical clinical JJ cord-339328-wizu3arz 132 32 tool tool NN cord-339328-wizu3arz 132 33 for for IN cord-339328-wizu3arz 132 34 the the DT cord-339328-wizu3arz 132 35 early early JJ cord-339328-wizu3arz 132 36 diagnosis diagnosis NN cord-339328-wizu3arz 132 37 and and CC cord-339328-wizu3arz 132 38 monitoring monitoring NN cord-339328-wizu3arz 132 39 of of IN cord-339328-wizu3arz 132 40 infectious infectious JJ cord-339328-wizu3arz 132 41 diseases disease NNS cord-339328-wizu3arz 132 42 in in IN cord-339328-wizu3arz 132 43 developing develop VBG cord-339328-wizu3arz 132 44 countries country NNS cord-339328-wizu3arz 132 45 . . . cord-339328-wizu3arz 133 1 Acknowledgements acknowledgement NNS cord-339328-wizu3arz 133 2 . . . cord-339328-wizu3arz 134 1 I -PRON- PRP cord-339328-wizu3arz 134 2 would would MD cord-339328-wizu3arz 134 3 like like VB cord-339328-wizu3arz 134 4 to to TO cord-339328-wizu3arz 134 5 thank thank VB cord-339328-wizu3arz 134 6 M. M. NNP cord-339328-wizu3arz 134 7 Mahesh Mahesh NNP cord-339328-wizu3arz 134 8 ( ( -LRB- cord-339328-wizu3arz 134 9 Chief Chief NNP cord-339328-wizu3arz 134 10 Physicist Physicist NNP cord-339328-wizu3arz 134 11 - - HYPH cord-339328-wizu3arz 134 12 Johns Johns NNP cord-339328-wizu3arz 134 13 Hopkins Hopkins NNP cord-339328-wizu3arz 134 14 Hospital Hospital NNP cord-339328-wizu3arz 134 15 ) ) -RRB- cord-339328-wizu3arz 134 16 for for IN cord-339328-wizu3arz 134 17 reviewing review VBG cord-339328-wizu3arz 134 18 the the DT cord-339328-wizu3arz 134 19 data datum NNS cord-339328-wizu3arz 134 20 on on IN cord-339328-wizu3arz 134 21 the the DT cord-339328-wizu3arz 134 22 radiation radiation NN cord-339328-wizu3arz 134 23 risks risk NNS cord-339328-wizu3arz 134 24 related relate VBN cord-339328-wizu3arz 134 25 to to IN cord-339328-wizu3arz 134 26 imaging imaging NN cord-339328-wizu3arz 134 27 techniques technique NNS cord-339328-wizu3arz 134 28 . . . cord-339328-wizu3arz 135 1 Funding funding NN cord-339328-wizu3arz 136 1 This this DT cord-339328-wizu3arz 136 2 review review NN cord-339328-wizu3arz 136 3 was be VBD cord-339328-wizu3arz 136 4 funded fund VBN cord-339328-wizu3arz 136 5 by by IN cord-339328-wizu3arz 136 6 the the DT cord-339328-wizu3arz 136 7 National National NNP cord-339328-wizu3arz 136 8 Institutes Institutes NNPS cord-339328-wizu3arz 136 9 of of IN cord-339328-wizu3arz 136 10 Health Health NNP cord-339328-wizu3arz 137 1 ( ( -LRB- cord-339328-wizu3arz 137 2 NIH NIH NNP cord-339328-wizu3arz 137 3 ) ) -RRB- cord-339328-wizu3arz 137 4 Director Director NNP cord-339328-wizu3arz 137 5 's 's POS cord-339328-wizu3arz 137 6 Transformative Transformative NNP cord-339328-wizu3arz 137 7 Research Research NNP cord-339328-wizu3arz 137 8 Award Award NNP cord-339328-wizu3arz 137 9 R01-EB020539 R01-EB020539 NNP cord-339328-wizu3arz 137 10 ( ( -LRB- cord-339328-wizu3arz 137 11 S.K.J. S.K.J. NNP cord-339328-wizu3arz 137 12 ) ) -RRB- cord-339328-wizu3arz 137 13 and and CC cord-339328-wizu3arz 137 14 the the DT cord-339328-wizu3arz 137 15 R01-HL131829 r01-hl131829 NN cord-339328-wizu3arz 137 16 ( ( -LRB- cord-339328-wizu3arz 137 17 S.K.J. S.K.J. NNP cord-339328-wizu3arz 137 18 ) ) -RRB- cord-339328-wizu3arz 137 19 as as RB cord-339328-wizu3arz 137 20 well well RB cord-339328-wizu3arz 137 21 as as IN cord-339328-wizu3arz 137 22 NIH NIH NNP cord-339328-wizu3arz 137 23 Director Director NNP cord-339328-wizu3arz 137 24 's 's POS cord-339328-wizu3arz 137 25 New New NNP cord-339328-wizu3arz 137 26 Innovator Innovator NNP cord-339328-wizu3arz 137 27 Award Award NNP cord-339328-wizu3arz 137 28 DP2-OD006492 DP2-OD006492 NNP cord-339328-wizu3arz 137 29 ( ( -LRB- cord-339328-wizu3arz 137 30 S.K.J. S.K.J. NNP cord-339328-wizu3arz 137 31 ) ) -RRB- cord-339328-wizu3arz 137 32 . . . cord-339328-wizu3arz 138 1 The the DT cord-339328-wizu3arz 138 2 funders funder NNS cord-339328-wizu3arz 138 3 had have VBD cord-339328-wizu3arz 138 4 no no DT cord-339328-wizu3arz 138 5 role role NN cord-339328-wizu3arz 138 6 in in IN cord-339328-wizu3arz 138 7 review review NN cord-339328-wizu3arz 138 8 design design NN cord-339328-wizu3arz 138 9 , , , cord-339328-wizu3arz 138 10 decision decision NN cord-339328-wizu3arz 138 11 to to TO cord-339328-wizu3arz 138 12 publish publish VB cord-339328-wizu3arz 138 13 , , , cord-339328-wizu3arz 138 14 or or CC cord-339328-wizu3arz 138 15 preparation preparation NN cord-339328-wizu3arz 138 16 of of IN cord-339328-wizu3arz 138 17 the the DT cord-339328-wizu3arz 138 18 manuscript manuscript NN cord-339328-wizu3arz 138 19 . . . cord-339328-wizu3arz 139 1 Antibiotic antibiotic JJ cord-339328-wizu3arz 139 2 resistance resistance NN cord-339328-wizu3arz 139 3 : : : cord-339328-wizu3arz 139 4 the the DT cord-339328-wizu3arz 139 5 last last JJ cord-339328-wizu3arz 139 6 resort resort NN cord-339328-wizu3arz 139 7 Mortality mortality NN cord-339328-wizu3arz 139 8 following follow VBG cord-339328-wizu3arz 139 9 bacteraemic bacteraemic NNP cord-339328-wizu3arz 139 10 infection infection NN cord-339328-wizu3arz 139 11 caused cause VBN cord-339328-wizu3arz 139 12 by by IN cord-339328-wizu3arz 139 13 extended extended JJ cord-339328-wizu3arz 139 14 spectrum spectrum NN cord-339328-wizu3arz 139 15 beta beta NN cord-339328-wizu3arz 139 16 - - HYPH cord-339328-wizu3arz 139 17 lactamase lactamase NN cord-339328-wizu3arz 139 18 ( ( -LRB- cord-339328-wizu3arz 139 19 ESBL ESBL NNP cord-339328-wizu3arz 139 20 ) ) -RRB- cord-339328-wizu3arz 139 21 producing produce VBG cord-339328-wizu3arz 139 22 E. E. NNP cord-339328-wizu3arz 139 23 coli coli NNS cord-339328-wizu3arz 139 24 compared compare VBN cord-339328-wizu3arz 139 25 to to IN cord-339328-wizu3arz 139 26 non non JJ cord-339328-wizu3arz 139 27 - - JJ cord-339328-wizu3arz 139 28 ESBL esbl JJ cord-339328-wizu3arz 139 29 producing produce VBG cord-339328-wizu3arz 139 30 E. E. NNP cord-339328-wizu3arz 139 31 coli coli NNS cord-339328-wizu3arz 139 32 Escherichia Escherichia NNP cord-339328-wizu3arz 139 33 coli coli NNS cord-339328-wizu3arz 140 1 Harboring harbor VBG cord-339328-wizu3arz 141 1 mcr-1 mcr-1 CD cord-339328-wizu3arz 142 1 and and CC cord-339328-wizu3arz 142 2 blaCTX blaCTX NNP cord-339328-wizu3arz 142 3 - - HYPH cord-339328-wizu3arz 142 4 M M NNP cord-339328-wizu3arz 142 5 on on IN cord-339328-wizu3arz 142 6 a a DT cord-339328-wizu3arz 142 7 novel novel JJ cord-339328-wizu3arz 142 8 IncF IncF NNP cord-339328-wizu3arz 142 9 plasmid plasmid NN cord-339328-wizu3arz 142 10 : : : cord-339328-wizu3arz 143 1 first first JJ cord-339328-wizu3arz 143 2 report report NN cord-339328-wizu3arz 143 3 of of IN cord-339328-wizu3arz 143 4 mcr-1 mcr-1 CD cord-339328-wizu3arz 143 5 in in IN cord-339328-wizu3arz 143 6 the the DT cord-339328-wizu3arz 143 7 United United NNP cord-339328-wizu3arz 143 8 States States NNP cord-339328-wizu3arz 143 9 Emergence Emergence NNP cord-339328-wizu3arz 143 10 of of IN cord-339328-wizu3arz 143 11 plasmidmediated plasmidmediated JJ cord-339328-wizu3arz 143 12 colistin colistin NNP cord-339328-wizu3arz 143 13 resistance resistance NN cord-339328-wizu3arz 143 14 mechanism mechanism NN cord-339328-wizu3arz 143 15 MCR-1 MCR-1 NNP cord-339328-wizu3arz 143 16 in in IN cord-339328-wizu3arz 143 17 animals animal NNS cord-339328-wizu3arz 143 18 and and CC cord-339328-wizu3arz 143 19 human human JJ cord-339328-wizu3arz 143 20 beings being NNS cord-339328-wizu3arz 143 21 in in IN cord-339328-wizu3arz 143 22 China China NNP cord-339328-wizu3arz 143 23 : : : cord-339328-wizu3arz 143 24 a a DT cord-339328-wizu3arz 143 25 microbiological microbiological JJ cord-339328-wizu3arz 143 26 and and CC cord-339328-wizu3arz 143 27 molecular molecular JJ cord-339328-wizu3arz 143 28 biological biological JJ cord-339328-wizu3arz 143 29 study study NN cord-339328-wizu3arz 143 30 Multistate Multistate NNP cord-339328-wizu3arz 143 31 pointprevalence pointprevalence NN cord-339328-wizu3arz 143 32 survey survey NN cord-339328-wizu3arz 143 33 of of IN cord-339328-wizu3arz 143 34 health health NN cord-339328-wizu3arz 143 35 care care NN cord-339328-wizu3arz 143 36 - - HYPH cord-339328-wizu3arz 143 37 associated associate VBN cord-339328-wizu3arz 143 38 infections infection NNS cord-339328-wizu3arz 143 39 CDC CDC NNP cord-339328-wizu3arz 143 40 Seasonal Seasonal NNP cord-339328-wizu3arz 143 41 Influenza Influenza NNP cord-339328-wizu3arz 143 42 - - HYPH cord-339328-wizu3arz 143 43 Associated Associated NNP cord-339328-wizu3arz 143 44 Hospitalizations Hospitalizations NNPS cord-339328-wizu3arz 143 45 in in IN cord-339328-wizu3arz 143 46 the the DT cord-339328-wizu3arz 143 47 United United NNP cord-339328-wizu3arz 143 48 States States NNP cord-339328-wizu3arz 143 49 WHO who WP cord-339328-wizu3arz 143 50 Global global JJ cord-339328-wizu3arz 143 51 tuberculosis tuberculosis NN cord-339328-wizu3arz 143 52 report report VBP cord-339328-wizu3arz 143 53 Extensively extensively RB cord-339328-wizu3arz 143 54 drugresistant drugresistant VBD cord-339328-wizu3arz 143 55 tuberculosis tuberculosis NN cord-339328-wizu3arz 143 56 in in IN cord-339328-wizu3arz 143 57 a a DT cord-339328-wizu3arz 143 58 young young JJ cord-339328-wizu3arz 143 59 child child NN cord-339328-wizu3arz 143 60 after after IN cord-339328-wizu3arz 143 61 travel travel NN cord-339328-wizu3arz 143 62 to to IN cord-339328-wizu3arz 143 63 India India NNP cord-339328-wizu3arz 143 64 Multidrug Multidrug NNP cord-339328-wizu3arz 143 65 - - HYPH cord-339328-wizu3arz 143 66 resistant resistant JJ cord-339328-wizu3arz 143 67 and and CC cord-339328-wizu3arz 143 68 extensively extensively RB cord-339328-wizu3arz 143 69 drug drug NN cord-339328-wizu3arz 143 70 - - HYPH cord-339328-wizu3arz 143 71 resistant resistant JJ cord-339328-wizu3arz 143 72 tuberculosis tuberculosis NN cord-339328-wizu3arz 143 73 : : : cord-339328-wizu3arz 143 74 a a DT cord-339328-wizu3arz 143 75 threat threat NN cord-339328-wizu3arz 143 76 to to IN cord-339328-wizu3arz 143 77 global global JJ cord-339328-wizu3arz 143 78 control control NN cord-339328-wizu3arz 143 79 of of IN cord-339328-wizu3arz 143 80 tuberculosis tuberculosis NN cord-339328-wizu3arz 143 81 Characterization characterization NN cord-339328-wizu3arz 143 82 of of IN cord-339328-wizu3arz 143 83 a a DT cord-339328-wizu3arz 143 84 novel novel JJ cord-339328-wizu3arz 143 85 coronavirus coronavirus NN cord-339328-wizu3arz 143 86 associated associate VBN cord-339328-wizu3arz 143 87 with with IN cord-339328-wizu3arz 143 88 severe severe JJ cord-339328-wizu3arz 143 89 acute acute JJ cord-339328-wizu3arz 143 90 respiratory respiratory JJ cord-339328-wizu3arz 143 91 syndrome syndrome NN cord-339328-wizu3arz 143 92 WHO who WP cord-339328-wizu3arz 143 93 Zika Zika NNP cord-339328-wizu3arz 143 94 virus virus NN cord-339328-wizu3arz 143 95 s s POS cord-339328-wizu3arz 143 96 principles principle NNS cord-339328-wizu3arz 143 97 and and CC cord-339328-wizu3arz 143 98 practice practice NN cord-339328-wizu3arz 143 99 of of IN cord-339328-wizu3arz 143 100 infectious infectious JJ cord-339328-wizu3arz 143 101 diseases disease NNS cord-339328-wizu3arz 143 102 Tumor tumor NN cord-339328-wizu3arz 143 103 necrosis necrosis NN cord-339328-wizu3arz 143 104 factor factor NN cord-339328-wizu3arz 143 105 signaling signaling NN cord-339328-wizu3arz 143 106 mediates mediate VBZ cord-339328-wizu3arz 143 107 resistance resistance NN cord-339328-wizu3arz 143 108 to to IN cord-339328-wizu3arz 143 109 mycobacteria mycobacterium NNS cord-339328-wizu3arz 143 110 by by IN cord-339328-wizu3arz 143 111 inhibiting inhibit VBG cord-339328-wizu3arz 143 112 bacterial bacterial JJ cord-339328-wizu3arz 143 113 growth growth NN cord-339328-wizu3arz 143 114 and and CC cord-339328-wizu3arz 143 115 macrophage macrophage NN cord-339328-wizu3arz 143 116 death death NN cord-339328-wizu3arz 143 117 Illuminating illuminate VBG cord-339328-wizu3arz 143 118 viral viral JJ cord-339328-wizu3arz 143 119 infections infection NNS cord-339328-wizu3arz 143 120 in in IN cord-339328-wizu3arz 143 121 the the DT cord-339328-wizu3arz 143 122 nervous nervous JJ cord-339328-wizu3arz 143 123 system system NN cord-339328-wizu3arz 144 1 Ipr1 ipr1 NN cord-339328-wizu3arz 144 2 gene gene NN cord-339328-wizu3arz 144 3 mediates mediate VBZ cord-339328-wizu3arz 144 4 innate innate JJ cord-339328-wizu3arz 144 5 immunity immunity NN cord-339328-wizu3arz 144 6 to to IN cord-339328-wizu3arz 144 7 tuberculosis tuberculosis NN cord-339328-wizu3arz 144 8 Mouse Mouse NNP cord-339328-wizu3arz 144 9 model model NN cord-339328-wizu3arz 144 10 of of IN cord-339328-wizu3arz 144 11 necrotic necrotic JJ cord-339328-wizu3arz 144 12 tuberculosis tuberculosis NN cord-339328-wizu3arz 144 13 granulomas granuloma NNS cord-339328-wizu3arz 144 14 develops develop VBZ cord-339328-wizu3arz 144 15 hypoxic hypoxic JJ cord-339328-wizu3arz 144 16 lesions lesion NNS cord-339328-wizu3arz 144 17 Mouse Mouse NNP cord-339328-wizu3arz 144 18 model model NN cord-339328-wizu3arz 144 19 of of IN cord-339328-wizu3arz 144 20 pulmonary pulmonary JJ cord-339328-wizu3arz 144 21 cavitary cavitary JJ cord-339328-wizu3arz 144 22 tuberculosis tuberculosis NN cord-339328-wizu3arz 144 23 and and CC cord-339328-wizu3arz 144 24 expression expression NN cord-339328-wizu3arz 144 25 of of IN cord-339328-wizu3arz 144 26 matrix matrix NN cord-339328-wizu3arz 144 27 metalloproteinase-9 metalloproteinase-9 NNP cord-339328-wizu3arz 144 28 Imaging Imaging NNP cord-339328-wizu3arz 145 1 the the DT cord-339328-wizu3arz 145 2 evolution evolution NN cord-339328-wizu3arz 145 3 of of IN cord-339328-wizu3arz 145 4 reactivation reactivation NN cord-339328-wizu3arz 145 5 pulmonary pulmonary JJ cord-339328-wizu3arz 145 6 tuberculosis tuberculosis NN cord-339328-wizu3arz 145 7 in in IN cord-339328-wizu3arz 145 8 mice mouse NNS cord-339328-wizu3arz 145 9 using use VBG cord-339328-wizu3arz 145 10 18 18 CD cord-339328-wizu3arz 145 11 F F NNP cord-339328-wizu3arz 145 12 - - HYPH cord-339328-wizu3arz 145 13 FDG FDG NNP cord-339328-wizu3arz 145 14 PET PET NNP cord-339328-wizu3arz 145 15 Sterilization Sterilization NNP cord-339328-wizu3arz 145 16 of of IN cord-339328-wizu3arz 145 17 granulomas granuloma NNS cord-339328-wizu3arz 145 18 is be VBZ cord-339328-wizu3arz 145 19 common common JJ cord-339328-wizu3arz 145 20 in in IN cord-339328-wizu3arz 145 21 active active JJ cord-339328-wizu3arz 145 22 and and CC cord-339328-wizu3arz 145 23 latent latent JJ cord-339328-wizu3arz 145 24 tuberculosis tuberculosis NN cord-339328-wizu3arz 145 25 despite despite IN cord-339328-wizu3arz 145 26 within within IN cord-339328-wizu3arz 145 27 - - HYPH cord-339328-wizu3arz 145 28 host host NN cord-339328-wizu3arz 145 29 variability variability NN cord-339328-wizu3arz 145 30 in in IN cord-339328-wizu3arz 145 31 bacterial bacterial JJ cord-339328-wizu3arz 145 32 killing kill VBG cord-339328-wizu3arz 145 33 Potential potential JJ cord-339328-wizu3arz 145 34 impact impact NN cord-339328-wizu3arz 145 35 of of IN cord-339328-wizu3arz 145 36 vancomycin vancomycin NN cord-339328-wizu3arz 145 37 pulmonary pulmonary JJ cord-339328-wizu3arz 145 38 distribution distribution NN cord-339328-wizu3arz 145 39 on on IN cord-339328-wizu3arz 145 40 treatment treatment NN cord-339328-wizu3arz 145 41 outcomes outcome NNS cord-339328-wizu3arz 145 42 in in IN cord-339328-wizu3arz 145 43 patients patient NNS cord-339328-wizu3arz 145 44 with with IN cord-339328-wizu3arz 145 45 methicillin methicillin NN cord-339328-wizu3arz 145 46 - - HYPH cord-339328-wizu3arz 145 47 resistant resistant JJ cord-339328-wizu3arz 145 48 Staphylococcus Staphylococcus NNP cord-339328-wizu3arz 145 49 aureus aureus NN cord-339328-wizu3arz 146 1 pneumonia pneumonia NN cord-339328-wizu3arz 147 1 The the DT cord-339328-wizu3arz 147 2 importance importance NN cord-339328-wizu3arz 147 3 of of IN cord-339328-wizu3arz 147 4 tissue tissue NN cord-339328-wizu3arz 147 5 penetration penetration NN cord-339328-wizu3arz 147 6 in in IN cord-339328-wizu3arz 147 7 achieving achieve VBG cord-339328-wizu3arz 147 8 successful successful JJ cord-339328-wizu3arz 147 9 antimicrobial antimicrobial JJ cord-339328-wizu3arz 147 10 treatment treatment NN cord-339328-wizu3arz 147 11 of of IN cord-339328-wizu3arz 147 12 nosocomial nosocomial JJ cord-339328-wizu3arz 147 13 pneumonia pneumonia NN cord-339328-wizu3arz 147 14 and and CC cord-339328-wizu3arz 147 15 complicated complicated JJ cord-339328-wizu3arz 147 16 skin skin NN cord-339328-wizu3arz 147 17 and and CC cord-339328-wizu3arz 147 18 soft soft JJ cord-339328-wizu3arz 147 19 - - HYPH cord-339328-wizu3arz 147 20 tissue tissue NN cord-339328-wizu3arz 147 21 infections infection NNS cord-339328-wizu3arz 147 22 caused cause VBN cord-339328-wizu3arz 147 23 by by IN cord-339328-wizu3arz 147 24 methicillin methicillin NN cord-339328-wizu3arz 147 25 - - HYPH cord-339328-wizu3arz 147 26 resistant resistant JJ cord-339328-wizu3arz 147 27 Staphylococcus Staphylococcus NNP cord-339328-wizu3arz 147 28 aureus aureus NN cord-339328-wizu3arz 147 29 : : : cord-339328-wizu3arz 147 30 vancomycin vancomycin NN cord-339328-wizu3arz 147 31 and and CC cord-339328-wizu3arz 147 32 linezolid linezolid NNP cord-339328-wizu3arz 148 1 Why why WRB cord-339328-wizu3arz 148 2 do do VBP cord-339328-wizu3arz 148 3 we -PRON- PRP cord-339328-wizu3arz 148 4 use use VB cord-339328-wizu3arz 148 5 600 600 CD cord-339328-wizu3arz 148 6 mg mg NN cord-339328-wizu3arz 148 7 of of IN cord-339328-wizu3arz 148 8 rifampicin rifampicin NNS cord-339328-wizu3arz 148 9 in in IN cord-339328-wizu3arz 148 10 tuberculosis tuberculosis NN cord-339328-wizu3arz 148 11 treatment treatment NN cord-339328-wizu3arz 148 12 ? ? . cord-339328-wizu3arz 149 1 Determination determination NN cord-339328-wizu3arz 149 2 of of IN cord-339328-wizu3arz 149 3 [ [ -LRB- cord-339328-wizu3arz 149 4 11 11 CD cord-339328-wizu3arz 149 5 C]rifampin C]rifampin NNP cord-339328-wizu3arz 149 6 pharmacokinetics pharmacokinetic NNS cord-339328-wizu3arz 149 7 within within IN cord-339328-wizu3arz 149 8 Mycobacterium Mycobacterium NNP cord-339328-wizu3arz 149 9 tuberculosisinfected tuberculosisinfecte VBD cord-339328-wizu3arz 149 10 mice mouse NNS cord-339328-wizu3arz 149 11 by by IN cord-339328-wizu3arz 149 12 using use VBG cord-339328-wizu3arz 149 13 dynamic dynamic JJ cord-339328-wizu3arz 149 14 positron positron NN cord-339328-wizu3arz 149 15 emission emission NN cord-339328-wizu3arz 149 16 tomography tomography NN cord-339328-wizu3arz 150 1 bioimaging bioimaging NNP cord-339328-wizu3arz 150 2 18 18 CD cord-339328-wizu3arz 150 3 F F NNP cord-339328-wizu3arz 150 4 - - HYPH cord-339328-wizu3arz 150 5 FDG FDG NNP cord-339328-wizu3arz 150 6 PET PET NNP cord-339328-wizu3arz 150 7 and and CC cord-339328-wizu3arz 150 8 PET/ PET/ NNP cord-339328-wizu3arz 150 9 CT CT NNP cord-339328-wizu3arz 150 10 in in IN cord-339328-wizu3arz 150 11 fever fever NN cord-339328-wizu3arz 150 12 of of IN cord-339328-wizu3arz 150 13 unknown unknown JJ cord-339328-wizu3arz 150 14 origin origin NN cord-339328-wizu3arz 150 15 Targeted target VBN cord-339328-wizu3arz 150 16 imaging imaging NN cord-339328-wizu3arz 150 17 of of IN cord-339328-wizu3arz 150 18 bacterial bacterial JJ cord-339328-wizu3arz 150 19 infections infection NNS cord-339328-wizu3arz 150 20 : : : cord-339328-wizu3arz 150 21 advances advance NNS cord-339328-wizu3arz 150 22 , , , cord-339328-wizu3arz 150 23 hurdles hurdle NNS cord-339328-wizu3arz 150 24 and and CC cord-339328-wizu3arz 150 25 hopes hope VBZ cord-339328-wizu3arz 150 26 Imaging Imaging NNP cord-339328-wizu3arz 150 27 bacteria bacteria NNS cord-339328-wizu3arz 150 28 with with IN cord-339328-wizu3arz 150 29 radiolabelled radiolabelled JJ cord-339328-wizu3arz 150 30 quinolones quinolone NNS cord-339328-wizu3arz 150 31 , , , cord-339328-wizu3arz 150 32 cephalosporins cephalosporin NNS cord-339328-wizu3arz 150 33 and and CC cord-339328-wizu3arz 150 34 siderophores siderophore NNS cord-339328-wizu3arz 150 35 for for IN cord-339328-wizu3arz 150 36 imaging image VBG cord-339328-wizu3arz 150 37 infection infection NN cord-339328-wizu3arz 150 38 : : : cord-339328-wizu3arz 150 39 a a DT cord-339328-wizu3arz 150 40 systematic systematic JJ cord-339328-wizu3arz 150 41 review review NN cord-339328-wizu3arz 150 42 Nuclear nuclear JJ cord-339328-wizu3arz 150 43 medicine medicine NN cord-339328-wizu3arz 150 44 and and CC cord-339328-wizu3arz 150 45 the the DT cord-339328-wizu3arz 150 46 infected infected JJ cord-339328-wizu3arz 150 47 joint joint JJ cord-339328-wizu3arz 150 48 replacement replacement NN cord-339328-wizu3arz 150 49 Preclinical preclinical JJ cord-339328-wizu3arz 150 50 evaluation evaluation NN cord-339328-wizu3arz 150 51 of of IN cord-339328-wizu3arz 150 52 68Ga 68Ga NNP cord-339328-wizu3arz 150 53 - - HYPH cord-339328-wizu3arz 150 54 labeled label VBN cord-339328-wizu3arz 150 55 1,4,7-triazacyclononane-1,4,7-triacetic 1,4,7-triazacyclononane-1,4,7-triacetic JJ cord-339328-wizu3arz 150 56 acid acid NN cord-339328-wizu3arz 150 57 - - HYPH cord-339328-wizu3arz 150 58 ubiquicidin ubiquicidin NNS cord-339328-wizu3arz 150 59 as as IN cord-339328-wizu3arz 150 60 a a DT cord-339328-wizu3arz 150 61 radioligand radioligand NN cord-339328-wizu3arz 150 62 for for IN cord-339328-wizu3arz 150 63 PET pet JJ cord-339328-wizu3arz 150 64 infection infection NN cord-339328-wizu3arz 150 65 imaging image VBG cord-339328-wizu3arz 150 66 Bacterial bacterial JJ cord-339328-wizu3arz 150 67 imaging imaging NN cord-339328-wizu3arz 150 68 comes come VBZ cord-339328-wizu3arz 150 69 of of IN cord-339328-wizu3arz 150 70 age age NN cord-339328-wizu3arz 150 71 A a DT cord-339328-wizu3arz 150 72 systematic systematic JJ cord-339328-wizu3arz 150 73 approach approach NN cord-339328-wizu3arz 150 74 for for IN cord-339328-wizu3arz 150 75 developing develop VBG cord-339328-wizu3arz 150 76 bacteria bacteria NNS cord-339328-wizu3arz 150 77 - - HYPH cord-339328-wizu3arz 150 78 specific specific JJ cord-339328-wizu3arz 150 79 imaging imaging NN cord-339328-wizu3arz 150 80 tracers tracer NNS cord-339328-wizu3arz 150 81 Imaging image VBG cord-339328-wizu3arz 150 82 bacterial bacterial JJ cord-339328-wizu3arz 150 83 infections infection NNS cord-339328-wizu3arz 150 84 with with IN cord-339328-wizu3arz 150 85 radiolabeled radiolabele VBN cord-339328-wizu3arz 150 86 1-(2′-deoxy-2′-fluoro 1-(2′-deoxy-2′-fluoro CD cord-339328-wizu3arz 150 87 - - HYPH cord-339328-wizu3arz 150 88 beta beta NN cord-339328-wizu3arz 150 89 - - HYPH cord-339328-wizu3arz 150 90 D d NN cord-339328-wizu3arz 150 91 - - HYPH cord-339328-wizu3arz 150 92 arabinofuranosyl)-5-iodouracil arabinofuranosyl)-5-iodouracil JJ cord-339328-wizu3arz 151 1 124 124 CD cord-339328-wizu3arz 152 1 I]FIAU i]fiau RB cord-339328-wizu3arz 152 2 : : : cord-339328-wizu3arz 152 3 human human JJ cord-339328-wizu3arz 152 4 dosimetry dosimetry NN cord-339328-wizu3arz 152 5 and and CC cord-339328-wizu3arz 152 6 infection infection NN cord-339328-wizu3arz 152 7 imaging imaging NN cord-339328-wizu3arz 152 8 in in IN cord-339328-wizu3arz 152 9 patients patient NNS cord-339328-wizu3arz 152 10 with with IN cord-339328-wizu3arz 152 11 suspected suspect VBN cord-339328-wizu3arz 152 12 prosthetic prosthetic JJ cord-339328-wizu3arz 152 13 joint joint JJ cord-339328-wizu3arz 152 14 infection infection NN cord-339328-wizu3arz 152 15 PET pet NN cord-339328-wizu3arz 152 16 imaging imaging NN cord-339328-wizu3arz 152 17 of of IN cord-339328-wizu3arz 152 18 bacterial bacterial JJ cord-339328-wizu3arz 152 19 infections infection NNS cord-339328-wizu3arz 152 20 with with IN cord-339328-wizu3arz 152 21 fluorine-18-labeled fluorine-18-labeled NNP cord-339328-wizu3arz 152 22 maltohexaose maltohexaose NNP cord-339328-wizu3arz 152 23 Investigation Investigation NNP cord-339328-wizu3arz 152 24 of of IN cord-339328-wizu3arz 152 25 6- 6- NNP cord-339328-wizu3arz 152 26 [ [ -LRB- cord-339328-wizu3arz 152 27 18 18 CD cord-339328-wizu3arz 152 28 F]-fluoromaltose F]-fluoromaltose NNP cord-339328-wizu3arz 152 29 as as IN cord-339328-wizu3arz 152 30 a a DT cord-339328-wizu3arz 152 31 novel novel JJ cord-339328-wizu3arz 152 32 PET pet NN cord-339328-wizu3arz 152 33 tracer tracer NN cord-339328-wizu3arz 152 34 for for IN cord-339328-wizu3arz 152 35 imaging image VBG cord-339328-wizu3arz 152 36 bacterial bacterial JJ cord-339328-wizu3arz 152 37 infection infection NN cord-339328-wizu3arz 152 38 Imaging Imaging NNP cord-339328-wizu3arz 152 39 Enterobacteriaceae Enterobacteriaceae NNP cord-339328-wizu3arz 152 40 infection infection NN cord-339328-wizu3arz 152 41 in in IN cord-339328-wizu3arz 152 42 vivo vivo NN cord-339328-wizu3arz 152 43 with with IN cord-339328-wizu3arz 152 44 18F 18F NNP cord-339328-wizu3arz 152 45 - - HYPH cord-339328-wizu3arz 152 46 fluorodeoxysorbitol fluorodeoxysorbitol JJ cord-339328-wizu3arz 152 47 positron positron NN cord-339328-wizu3arz 152 48 emission emission NN cord-339328-wizu3arz 152 49 tomography tomography NN cord-339328-wizu3arz 152 50 Deoxyfluoro Deoxyfluoro NNP cord-339328-wizu3arz 152 51 - - HYPH cord-339328-wizu3arz 152 52 dtrehalose dtrehalose NNP cord-339328-wizu3arz 153 1 ( ( -LRB- cord-339328-wizu3arz 153 2 FDTre FDTre NNP cord-339328-wizu3arz 153 3 ) ) -RRB- cord-339328-wizu3arz 153 4 analogues analogue NNS cord-339328-wizu3arz 153 5 as as IN cord-339328-wizu3arz 153 6 potential potential JJ cord-339328-wizu3arz 153 7 PET pet NN cord-339328-wizu3arz 153 8 probes probe NNS cord-339328-wizu3arz 153 9 for for IN cord-339328-wizu3arz 153 10 imaging image VBG cord-339328-wizu3arz 153 11 mycobacterial mycobacterial JJ cord-339328-wizu3arz 153 12 infection infection NN cord-339328-wizu3arz 154 1 Ga Ga NNP cord-339328-wizu3arz 154 2 - - HYPH cord-339328-wizu3arz 154 3 siderophores siderophores NNP cord-339328-wizu3arz 154 4 for for IN cord-339328-wizu3arz 154 5 PET pet NN cord-339328-wizu3arz 154 6 imaging imaging NN cord-339328-wizu3arz 154 7 of of IN cord-339328-wizu3arz 154 8 invasive invasive JJ cord-339328-wizu3arz 154 9 pulmonary pulmonary JJ cord-339328-wizu3arz 154 10 aspergillosis aspergillosis NN cord-339328-wizu3arz 154 11 : : : cord-339328-wizu3arz 154 12 proof proof NN cord-339328-wizu3arz 154 13 of of IN cord-339328-wizu3arz 154 14 principle principle NN cord-339328-wizu3arz 154 15 ImmunoPET ImmunoPET NNPS cord-339328-wizu3arz 155 1 / / NFP cord-339328-wizu3arz 156 1 MR MR NNP cord-339328-wizu3arz 156 2 imaging imaging NN cord-339328-wizu3arz 156 3 allows allow VBZ cord-339328-wizu3arz 156 4 specific specific JJ cord-339328-wizu3arz 156 5 detection detection NN cord-339328-wizu3arz 156 6 of of IN cord-339328-wizu3arz 156 7 Aspergillus aspergillus NN cord-339328-wizu3arz 156 8 fumigatus fumigatus NN cord-339328-wizu3arz 156 9 lung lung NN cord-339328-wizu3arz 156 10 infection infection NN cord-339328-wizu3arz 156 11 in in IN cord-339328-wizu3arz 156 12 vivo vivo NNP cord-339328-wizu3arz 156 13 New new JJ cord-339328-wizu3arz 156 14 pathogen pathogen NN cord-339328-wizu3arz 156 15 - - HYPH cord-339328-wizu3arz 156 16 specific specific JJ cord-339328-wizu3arz 156 17 immunoPET immunoPET NNP cord-339328-wizu3arz 156 18 / / SYM cord-339328-wizu3arz 156 19 MR MR NNP cord-339328-wizu3arz 156 20 tracer tracer NN cord-339328-wizu3arz 156 21 for for IN cord-339328-wizu3arz 156 22 molecular molecular JJ cord-339328-wizu3arz 156 23 imaging imaging NN cord-339328-wizu3arz 156 24 of of IN cord-339328-wizu3arz 156 25 a a DT cord-339328-wizu3arz 156 26 systemic systemic JJ cord-339328-wizu3arz 156 27 bacterial bacterial JJ cord-339328-wizu3arz 156 28 infection infection NN cord-339328-wizu3arz 157 1 Whole whole JJ cord-339328-wizu3arz 157 2 - - HYPH cord-339328-wizu3arz 157 3 body body NN cord-339328-wizu3arz 157 4 immunoPET immunoPET NNP cord-339328-wizu3arz 157 5 reveals reveal VBZ cord-339328-wizu3arz 157 6 active active JJ cord-339328-wizu3arz 157 7 SIV SIV NNP cord-339328-wizu3arz 157 8 dynamics dynamic NNS cord-339328-wizu3arz 157 9 in in IN cord-339328-wizu3arz 157 10 viremic viremic JJ cord-339328-wizu3arz 157 11 and and CC cord-339328-wizu3arz 157 12 antiretroviral antiretroviral JJ cord-339328-wizu3arz 157 13 therapy therapy NN cord-339328-wizu3arz 157 14 - - HYPH cord-339328-wizu3arz 157 15 treated treat VBN cord-339328-wizu3arz 157 16 macaques macaque NNS cord-339328-wizu3arz 157 17 Detection Detection NNP cord-339328-wizu3arz 157 18 of of IN cord-339328-wizu3arz 157 19 Klebsiella Klebsiella NNP cord-339328-wizu3arz 157 20 . . . cord-339328-wizu3arz 158 1 Pneumoniae pneumoniae NN cord-339328-wizu3arz 158 2 infection infection NN cord-339328-wizu3arz 158 3 with with IN cord-339328-wizu3arz 158 4 an an DT cord-339328-wizu3arz 158 5 antisense antisense NN cord-339328-wizu3arz 158 6 oligomer oligomer NNP cord-339328-wizu3arz 158 7 against against IN cord-339328-wizu3arz 158 8 its -PRON- PRP$ cord-339328-wizu3arz 158 9 ribosomal ribosomal JJ cord-339328-wizu3arz 158 10 RNA RNA NNP cord-339328-wizu3arz 158 11 Detection Detection NNP cord-339328-wizu3arz 158 12 of of IN cord-339328-wizu3arz 158 13 Aspergillus aspergillus NN cord-339328-wizu3arz 158 14 fumigatus fumigatus NN cord-339328-wizu3arz 158 15 pulmonary pulmonary JJ cord-339328-wizu3arz 158 16 fungal fungal JJ cord-339328-wizu3arz 158 17 infections infection NNS cord-339328-wizu3arz 158 18 in in IN cord-339328-wizu3arz 158 19 mice mouse NNS cord-339328-wizu3arz 158 20 with with IN cord-339328-wizu3arz 158 21 99 99 CD cord-339328-wizu3arz 158 22 m m NN cord-339328-wizu3arz 158 23 Tc Tc NNP cord-339328-wizu3arz 158 24 - - HYPH cord-339328-wizu3arz 158 25 labeled label VBN cord-339328-wizu3arz 158 26 MORF MORF NNP cord-339328-wizu3arz 158 27 oligomers oligomer NNS cord-339328-wizu3arz 158 28 targeting target VBG cord-339328-wizu3arz 158 29 ribosomal ribosomal JJ cord-339328-wizu3arz 158 30 RNA RNA NNP cord-339328-wizu3arz 158 31 Noninvasive noninvasive JJ cord-339328-wizu3arz 158 32 imaging imaging NN cord-339328-wizu3arz 158 33 of of IN cord-339328-wizu3arz 158 34 infection infection NN cord-339328-wizu3arz 158 35 after after IN cord-339328-wizu3arz 158 36 treatment treatment NN cord-339328-wizu3arz 158 37 with with IN cord-339328-wizu3arz 158 38 tumor tumor NN cord-339328-wizu3arz 158 39 - - HYPH cord-339328-wizu3arz 158 40 homing home VBG cord-339328-wizu3arz 158 41 bacteria bacteria NNS cord-339328-wizu3arz 158 42 using use VBG cord-339328-wizu3arz 158 43 chemical chemical JJ cord-339328-wizu3arz 158 44 exchange exchange NN cord-339328-wizu3arz 158 45 saturation saturation NN cord-339328-wizu3arz 158 46 transfer transfer NN cord-339328-wizu3arz 158 47 ( ( -LRB- cord-339328-wizu3arz 158 48 CEST CEST NNP cord-339328-wizu3arz 158 49 ) ) -RRB- cord-339328-wizu3arz 158 50 MRI MRI NNP cord-339328-wizu3arz 158 51 Radioiodinated Radioiodinated NNP cord-339328-wizu3arz 158 52 DPA-713 DPA-713 NNP cord-339328-wizu3arz 158 53 imaging imaging NN cord-339328-wizu3arz 158 54 correlates correlate VBZ cord-339328-wizu3arz 158 55 with with IN cord-339328-wizu3arz 158 56 bactericidal bactericidal JJ cord-339328-wizu3arz 158 57 activity activity NN cord-339328-wizu3arz 158 58 of of IN cord-339328-wizu3arz 158 59 tuberculosis tuberculosis NN cord-339328-wizu3arz 158 60 treatments treatment NNS cord-339328-wizu3arz 158 61 in in IN cord-339328-wizu3arz 158 62 mice mouse NNS cord-339328-wizu3arz 159 1 Noninvasive noninvasive JJ cord-339328-wizu3arz 159 2 pulmonary pulmonary NN cord-339328-wizu3arz 160 1 [ [ -LRB- cord-339328-wizu3arz 160 2 18F]-2-fluoro 18f]-2-fluoro CD cord-339328-wizu3arz 160 3 - - HYPH cord-339328-wizu3arz 160 4 deoxy deoxy NN cord-339328-wizu3arz 160 5 - - HYPH cord-339328-wizu3arz 160 6 D d JJ cord-339328-wizu3arz 160 7 - - HYPH cord-339328-wizu3arz 160 8 glucose glucose NN cord-339328-wizu3arz 160 9 positron positron NN cord-339328-wizu3arz 160 10 emission emission NN cord-339328-wizu3arz 160 11 tomography tomography NN cord-339328-wizu3arz 160 12 correlates correlate VBZ cord-339328-wizu3arz 160 13 with with IN cord-339328-wizu3arz 160 14 bactericidal bactericidal JJ cord-339328-wizu3arz 160 15 activity activity NN cord-339328-wizu3arz 160 16 of of IN cord-339328-wizu3arz 160 17 tuberculosis tuberculosis NN cord-339328-wizu3arz 160 18 drug drug NN cord-339328-wizu3arz 160 19 treatment treatment NN cord-339328-wizu3arz 160 20 Use Use NNP cord-339328-wizu3arz 160 21 of of IN cord-339328-wizu3arz 160 22 18 18 CD cord-339328-wizu3arz 160 23 F F NNP cord-339328-wizu3arz 160 24 - - HYPH cord-339328-wizu3arz 160 25 FDG FDG NNP cord-339328-wizu3arz 160 26 PET PET NNP cord-339328-wizu3arz 160 27 to to TO cord-339328-wizu3arz 160 28 predict predict VB cord-339328-wizu3arz 160 29 response response NN cord-339328-wizu3arz 160 30 to to IN cord-339328-wizu3arz 160 31 first first JJ cord-339328-wizu3arz 160 32 - - HYPH cord-339328-wizu3arz 160 33 line line NN cord-339328-wizu3arz 160 34 tuberculostatics tuberculostatic NNS cord-339328-wizu3arz 160 35 in in IN cord-339328-wizu3arz 160 36 HIV HIV NNP cord-339328-wizu3arz 160 37 - - HYPH cord-339328-wizu3arz 160 38 associated associate VBN cord-339328-wizu3arz 160 39 tuberculosis tuberculosis NN cord-339328-wizu3arz 160 40 Antibiotic antibiotic JJ cord-339328-wizu3arz 160 41 treatment treatment NN cord-339328-wizu3arz 160 42 of of IN cord-339328-wizu3arz 160 43 tuberculosis tuberculosis NN cord-339328-wizu3arz 160 44 : : : cord-339328-wizu3arz 160 45 old old JJ cord-339328-wizu3arz 160 46 problems problem NNS cord-339328-wizu3arz 161 1 PET PET NNP cord-339328-wizu3arz 161 2 / / SYM cord-339328-wizu3arz 161 3 CT CT NNP cord-339328-wizu3arz 161 4 imaging imaging NN cord-339328-wizu3arz 161 5 correlates correlate VBZ cord-339328-wizu3arz 161 6 with with IN cord-339328-wizu3arz 161 7 treatment treatment NN cord-339328-wizu3arz 161 8 outcome outcome NN cord-339328-wizu3arz 161 9 in in IN cord-339328-wizu3arz 161 10 patients patient NNS cord-339328-wizu3arz 161 11 with with IN cord-339328-wizu3arz 161 12 multidrug multidrug NN cord-339328-wizu3arz 161 13 - - HYPH cord-339328-wizu3arz 161 14 resistant resistant JJ cord-339328-wizu3arz 161 15 tuberculosis tuberculosis NN cord-339328-wizu3arz 161 16 Applications application NNS cord-339328-wizu3arz 161 17 of of IN cord-339328-wizu3arz 161 18 in in IN cord-339328-wizu3arz 161 19 vivo vivo NN cord-339328-wizu3arz 161 20 imaging imaging NN cord-339328-wizu3arz 161 21 in in IN cord-339328-wizu3arz 161 22 the the DT cord-339328-wizu3arz 161 23 evaluation evaluation NN cord-339328-wizu3arz 161 24 of of IN cord-339328-wizu3arz 161 25 the the DT cord-339328-wizu3arz 161 26 pathophysiology pathophysiology NN cord-339328-wizu3arz 161 27 of of IN cord-339328-wizu3arz 161 28 viral viral JJ cord-339328-wizu3arz 161 29 and and CC cord-339328-wizu3arz 161 30 bacterial bacterial JJ cord-339328-wizu3arz 161 31 infections infection NNS cord-339328-wizu3arz 161 32 and and CC cord-339328-wizu3arz 161 33 in in IN cord-339328-wizu3arz 161 34 development development NN cord-339328-wizu3arz 161 35 of of IN cord-339328-wizu3arz 161 36 countermeasures countermeasure NNS cord-339328-wizu3arz 161 37 to to IN cord-339328-wizu3arz 161 38 BSL3/4 BSL3/4 . cord-339328-wizu3arz 162 1 pathogens pathogen NNS cord-339328-wizu3arz 162 2 Bacterial bacterial JJ cord-339328-wizu3arz 162 3 thymidine thymidine NN cord-339328-wizu3arz 162 4 kinase kinase VBZ cord-339328-wizu3arz 162 5 as as IN cord-339328-wizu3arz 162 6 a a DT cord-339328-wizu3arz 162 7 non non JJ cord-339328-wizu3arz 162 8 - - JJ cord-339328-wizu3arz 162 9 invasive invasive JJ cord-339328-wizu3arz 162 10 imaging imaging NN cord-339328-wizu3arz 162 11 reporter reporter NN cord-339328-wizu3arz 162 12 for for IN cord-339328-wizu3arz 162 13 Mycobacterium Mycobacterium NNP cord-339328-wizu3arz 162 14 tuberculosis tuberculosis NN cord-339328-wizu3arz 162 15 in in IN cord-339328-wizu3arz 162 16 live live JJ cord-339328-wizu3arz 162 17 animals animal NNS cord-339328-wizu3arz 162 18 Microglia Microglia NNP cord-339328-wizu3arz 162 19 activation activation NN cord-339328-wizu3arz 162 20 in in IN cord-339328-wizu3arz 162 21 a a DT cord-339328-wizu3arz 162 22 pediatric pediatric JJ cord-339328-wizu3arz 162 23 rabbit rabbit NN cord-339328-wizu3arz 162 24 model model NN cord-339328-wizu3arz 162 25 of of IN cord-339328-wizu3arz 162 26 tuberculous tuberculous JJ cord-339328-wizu3arz 162 27 meningitis meningitis NN cord-339328-wizu3arz 162 28 ABSL-4 ABSL-4 NNP cord-339328-wizu3arz 162 29 aerobiology aerobiology NNP cord-339328-wizu3arz 162 30 biosafety biosafety NN cord-339328-wizu3arz 162 31 and and CC cord-339328-wizu3arz 162 32 technology technology NN cord-339328-wizu3arz 162 33 at at IN cord-339328-wizu3arz 162 34 the the DT cord-339328-wizu3arz 162 35 NIH NIH NNP cord-339328-wizu3arz 162 36 / / SYM cord-339328-wizu3arz 162 37 NIAID NIAID NNP cord-339328-wizu3arz 162 38 integrated integrate VBD cord-339328-wizu3arz 162 39 research research NN cord-339328-wizu3arz 162 40 facility facility NN cord-339328-wizu3arz 162 41 at at IN cord-339328-wizu3arz 162 42 Fort Fort NNP cord-339328-wizu3arz 162 43 Detrick Detrick NNP cord-339328-wizu3arz 163 1 Noninvasive noninvasive JJ cord-339328-wizu3arz 163 2 determination determination NN cord-339328-wizu3arz 163 3 of of IN cord-339328-wizu3arz 163 4 2- 2- NN cord-339328-wizu3arz 163 5 [ [ -LRB- cord-339328-wizu3arz 163 6 18 18 CD cord-339328-wizu3arz 163 7 F]-fluoroisonicotinic F]-fluoroisonicotinic NNP cord-339328-wizu3arz 163 8 acid acid NN cord-339328-wizu3arz 163 9 hydrazide hydrazide NN cord-339328-wizu3arz 163 10 pharmacokinetics pharmacokinetic NNS cord-339328-wizu3arz 163 11 by by IN cord-339328-wizu3arz 163 12 positron positron NN cord-339328-wizu3arz 163 13 emission emission NN cord-339328-wizu3arz 163 14 tomography tomography NN cord-339328-wizu3arz 163 15 in in IN cord-339328-wizu3arz 163 16 Mycobacterium Mycobacterium NNP cord-339328-wizu3arz 163 17 tuberculosis tuberculosis NN cord-339328-wizu3arz 163 18 - - HYPH cord-339328-wizu3arz 163 19 infected infect VBN cord-339328-wizu3arz 163 20 mice mouse NNS cord-339328-wizu3arz 164 1 Radiation radiation NN cord-339328-wizu3arz 164 2 doses dose NNS cord-339328-wizu3arz 164 3 and and CC cord-339328-wizu3arz 164 4 cancer cancer NN cord-339328-wizu3arz 164 5 risks risk NNS cord-339328-wizu3arz 164 6 from from IN cord-339328-wizu3arz 164 7 breast breast NN cord-339328-wizu3arz 164 8 imaging imaging NN cord-339328-wizu3arz 164 9 studies study NNS cord-339328-wizu3arz 164 10 Guidance guidance NN cord-339328-wizu3arz 164 11 : : : cord-339328-wizu3arz 164 12 ionising ionise VBG cord-339328-wizu3arz 164 13 radiation radiation NN cord-339328-wizu3arz 164 14 : : : cord-339328-wizu3arz 165 1 dose dose NN cord-339328-wizu3arz 165 2 comparisons comparison NNS cord-339328-wizu3arz 165 3 Effective effective JJ cord-339328-wizu3arz 165 4 doses dose NNS cord-339328-wizu3arz 165 5 in in IN cord-339328-wizu3arz 165 6 radiology radiology NN cord-339328-wizu3arz 165 7 and and CC cord-339328-wizu3arz 165 8 diagnostic diagnostic JJ cord-339328-wizu3arz 165 9 nuclear nuclear JJ cord-339328-wizu3arz 165 10 medicine medicine NN cord-339328-wizu3arz 165 11 : : : cord-339328-wizu3arz 165 12 a a DT cord-339328-wizu3arz 165 13 catalog catalog NN cord-339328-wizu3arz 165 14 Mortality mortality NN cord-339328-wizu3arz 165 15 among among IN cord-339328-wizu3arz 165 16 MDR MDR NNP cord-339328-wizu3arz 165 17 - - HYPH cord-339328-wizu3arz 165 18 TB TB NNP cord-339328-wizu3arz 165 19 cases case NNS cord-339328-wizu3arz 165 20 : : : cord-339328-wizu3arz 165 21 comparison comparison NN cord-339328-wizu3arz 165 22 with with IN cord-339328-wizu3arz 165 23 drug drug NN cord-339328-wizu3arz 165 24 - - HYPH cord-339328-wizu3arz 165 25 susceptible susceptible JJ cord-339328-wizu3arz 165 26 tuberculosis tuberculosis NN cord-339328-wizu3arz 165 27 and and CC cord-339328-wizu3arz 165 28 associated associate VBN cord-339328-wizu3arz 165 29 factors factor NNS cord-339328-wizu3arz 165 30 Factors factor NNS cord-339328-wizu3arz 165 31 associated associate VBN cord-339328-wizu3arz 165 32 with with IN cord-339328-wizu3arz 165 33 mortality mortality NN cord-339328-wizu3arz 165 34 in in IN cord-339328-wizu3arz 165 35 patients patient NNS cord-339328-wizu3arz 165 36 with with IN cord-339328-wizu3arz 165 37 drug drug NN cord-339328-wizu3arz 165 38 - - HYPH cord-339328-wizu3arz 165 39 susceptible susceptible JJ cord-339328-wizu3arz 165 40 pulmonary pulmonary JJ cord-339328-wizu3arz 165 41 tuberculosis tuberculosis NN cord-339328-wizu3arz 165 42 Radiation radiation NN cord-339328-wizu3arz 165 43 doses dose NNS cord-339328-wizu3arz 165 44 for for IN cord-339328-wizu3arz 165 45 pediatric pediatric JJ cord-339328-wizu3arz 165 46 nuclear nuclear JJ cord-339328-wizu3arz 165 47 medicine medicine NN cord-339328-wizu3arz 165 48 studies study NNS cord-339328-wizu3arz 165 49 : : : cord-339328-wizu3arz 165 50 comparing compare VBG cord-339328-wizu3arz 165 51 the the DT cord-339328-wizu3arz 165 52 North north JJ cord-339328-wizu3arz 165 53 American american JJ cord-339328-wizu3arz 165 54 consensus consensus NN cord-339328-wizu3arz 165 55 guidelines guideline NNS cord-339328-wizu3arz 165 56 and and CC cord-339328-wizu3arz 165 57 the the DT cord-339328-wizu3arz 165 58 pediatric pediatric JJ cord-339328-wizu3arz 165 59 dosage dosage NN cord-339328-wizu3arz 165 60 card card NN cord-339328-wizu3arz 165 61 of of IN cord-339328-wizu3arz 165 62 the the DT cord-339328-wizu3arz 165 63 European European NNP cord-339328-wizu3arz 165 64 Association Association NNP cord-339328-wizu3arz 165 65 of of IN cord-339328-wizu3arz 165 66 Nuclear Nuclear NNP cord-339328-wizu3arz 165 67 Medicine Medicine NNP cord-339328-wizu3arz 165 68 INDs ind NNS cord-339328-wizu3arz 165 69 for for IN cord-339328-wizu3arz 165 70 PET pet JJ cord-339328-wizu3arz 165 71 molecular molecular JJ cord-339328-wizu3arz 165 72 imaging imaging NN cord-339328-wizu3arz 165 73 probes probe NNS cord-339328-wizu3arz 165 74 - - : cord-339328-wizu3arz 165 75 approach approach NN cord-339328-wizu3arz 165 76 by by IN cord-339328-wizu3arz 165 77 an an DT cord-339328-wizu3arz 165 78 academic academic JJ cord-339328-wizu3arz 165 79 institution institution NN cord-339328-wizu3arz 165 80 Biodistribution Biodistribution NNP cord-339328-wizu3arz 165 81 and and CC cord-339328-wizu3arz 165 82 radiation radiation NN cord-339328-wizu3arz 165 83 dosimetry dosimetry NN cord-339328-wizu3arz 165 84 of of IN cord-339328-wizu3arz 165 85 the the DT cord-339328-wizu3arz 165 86 Enterobacteriaceae Enterobacteriaceae NNP cord-339328-wizu3arz 165 87 - - HYPH cord-339328-wizu3arz 165 88 specific specific JJ cord-339328-wizu3arz 165 89 imaging imaging NN cord-339328-wizu3arz 165 90 probe probe NN cord-339328-wizu3arz 165 91 [ [ -LRB- cord-339328-wizu3arz 165 92 18 18 CD cord-339328-wizu3arz 165 93 F]fluorodeoxysorbitol F]fluorodeoxysorbitol NNP cord-339328-wizu3arz 165 94 determined determine VBN cord-339328-wizu3arz 165 95 by by IN cord-339328-wizu3arz 165 96 PET PET NNP cord-339328-wizu3arz 165 97 / / SYM cord-339328-wizu3arz 165 98 CT CT NNP cord-339328-wizu3arz 165 99 in in IN cord-339328-wizu3arz 165 100 healthy healthy JJ cord-339328-wizu3arz 165 101 human human JJ cord-339328-wizu3arz 165 102 volunteers volunteer NNS cord-339328-wizu3arz 165 103 Commentary commentary NN cord-339328-wizu3arz 165 104 - - HYPH cord-339328-wizu3arz 165 105 radiology radiology NN cord-339328-wizu3arz 165 106 in in IN cord-339328-wizu3arz 165 107 India India NNP cord-339328-wizu3arz 165 108 : : : cord-339328-wizu3arz 166 1 the the DT cord-339328-wizu3arz 166 2 next next JJ cord-339328-wizu3arz 166 3 decade decade NN cord-339328-wizu3arz 166 4 Radiology Radiology NNP cord-339328-wizu3arz 166 5 in in IN cord-339328-wizu3arz 166 6 India India NNP cord-339328-wizu3arz 166 7 : : : cord-339328-wizu3arz 166 8 trends trend NNS cord-339328-wizu3arz 166 9 in in IN cord-339328-wizu3arz 166 10 medical medical JJ cord-339328-wizu3arz 166 11 imaging imaging NN cord-339328-wizu3arz 166 12 technology technology NN cord-339328-wizu3arz 166 13 2050 2050 CD cord-339328-wizu3arz 167 1 The the DT cord-339328-wizu3arz 167 2 author author NN cord-339328-wizu3arz 167 3 declares declare VBZ cord-339328-wizu3arz 167 4 that that IN cord-339328-wizu3arz 167 5 he -PRON- PRP cord-339328-wizu3arz 167 6 has have VBZ cord-339328-wizu3arz 167 7 no no DT cord-339328-wizu3arz 167 8 conflict conflict NN cord-339328-wizu3arz 167 9 of of IN cord-339328-wizu3arz 167 10 interest interest NN cord-339328-wizu3arz 167 11 . . .