id	sid	tid	token	lemma	pos
cord-335871-zieuc7vk	1	1	key	key	NN
cord-335871-zieuc7vk	1	2	:	:	:
cord-335871-zieuc7vk	1	3	cord-335871-zieuc7vk	cord-335871-zieuc7vk	NN
cord-335871-zieuc7vk	1	4	authors	author	NNS
cord-335871-zieuc7vk	1	5	:	:	:
cord-335871-zieuc7vk	1	6	Brazee	Brazee	NNP
cord-335871-zieuc7vk	1	7	,	,	,
cord-335871-zieuc7vk	1	8	Patricia	Patricia	NNP
cord-335871-zieuc7vk	1	9	L.	L.	NNP
cord-335871-zieuc7vk	1	10	;	;	:
cord-335871-zieuc7vk	1	11	Sznajder	Sznajder	NNP
cord-335871-zieuc7vk	1	12	,	,	,
cord-335871-zieuc7vk	1	13	Jacob	Jacob	NNP
cord-335871-zieuc7vk	1	14	I.	I.	NNP
cord-335871-zieuc7vk	1	15	title	title	NN
cord-335871-zieuc7vk	1	16	:	:	:
cord-335871-zieuc7vk	2	1	Targeting	target	VBG
cord-335871-zieuc7vk	2	2	the	the	DT
cord-335871-zieuc7vk	2	3	Linear	Linear	NNP
cord-335871-zieuc7vk	2	4	Ubiquitin	Ubiquitin	NNP
cord-335871-zieuc7vk	2	5	Assembly	Assembly	NNP
cord-335871-zieuc7vk	2	6	Complex	Complex	NNP
cord-335871-zieuc7vk	2	7	to	to	TO
cord-335871-zieuc7vk	2	8	Modulate	modulate	VB
cord-335871-zieuc7vk	2	9	the	the	DT
cord-335871-zieuc7vk	2	10	Host	Host	NNP
cord-335871-zieuc7vk	2	11	Response	response	NN
cord-335871-zieuc7vk	2	12	and	and	CC
cord-335871-zieuc7vk	2	13	Improve	improve	VB
cord-335871-zieuc7vk	3	1	Influenza	Influenza	NNP
cord-335871-zieuc7vk	3	2	A	a	DT
cord-335871-zieuc7vk	3	3	Virus	virus	NN
cord-335871-zieuc7vk	3	4	Induced	Induced	NNP
cord-335871-zieuc7vk	3	5	Lung	Lung	NNP
cord-335871-zieuc7vk	3	6	Injury	injury	NN
cord-335871-zieuc7vk	3	7	date	date	NN
cord-335871-zieuc7vk	3	8	:	:	:
cord-335871-zieuc7vk	3	9	2020	2020	CD
cord-335871-zieuc7vk	3	10	-	-	HYPH
cord-335871-zieuc7vk	3	11	05	05	CD
cord-335871-zieuc7vk	3	12	-	-	SYM
cord-335871-zieuc7vk	3	13	13	13	CD
cord-335871-zieuc7vk	3	14	journal	journal	NN
cord-335871-zieuc7vk	3	15	:	:	:
cord-335871-zieuc7vk	4	1	Arch	arch	JJ
cord-335871-zieuc7vk	4	2	Bronconeumol	Bronconeumol	NNP
cord-335871-zieuc7vk	4	3	DOI	doi	NN
cord-335871-zieuc7vk	4	4	:	:	:
cord-335871-zieuc7vk	4	5	10.1016/	10.1016/	CD
cord-335871-zieuc7vk	5	1	j.arbres.2020.04.019	j.arbres.2020.04.019	NNP
cord-335871-zieuc7vk	5	2	sha	sha	XX
cord-335871-zieuc7vk	5	3	:	:	:
cord-335871-zieuc7vk	6	1	c0b85e7f8627c38dda91271859949d131bbc0ae1	c0b85e7f8627c38dda91271859949d131bbc0ae1	CC
cord-335871-zieuc7vk	6	2	doc_id	doc_id	CD
cord-335871-zieuc7vk	6	3	:	:	:
cord-335871-zieuc7vk	6	4	335871	335871	CD
cord-335871-zieuc7vk	6	5	cord_uid	cord_uid	NN
cord-335871-zieuc7vk	6	6	:	:	:
cord-335871-zieuc7vk	7	1	zieuc7vk	zieuc7vk	NNP
cord-335871-zieuc7vk	7	2	Abstract	Abstract	NNP
cord-335871-zieuc7vk	7	3	Influenza	Influenza	NNP
cord-335871-zieuc7vk	7	4	virus	virus	NN
cord-335871-zieuc7vk	7	5	infection	infection	NN
cord-335871-zieuc7vk	7	6	is	be	VBZ
cord-335871-zieuc7vk	7	7	characterized	characterize	VBN
cord-335871-zieuc7vk	7	8	by	by	IN
cord-335871-zieuc7vk	7	9	symptoms	symptom	NNS
cord-335871-zieuc7vk	7	10	ranging	range	VBG
cord-335871-zieuc7vk	7	11	from	from	IN
cord-335871-zieuc7vk	7	12	mild	mild	JJ
cord-335871-zieuc7vk	7	13	congestion	congestion	NN
cord-335871-zieuc7vk	7	14	and	and	CC
cord-335871-zieuc7vk	7	15	body	body	NN
cord-335871-zieuc7vk	7	16	aches	ache	NNS
cord-335871-zieuc7vk	7	17	to	to	IN
cord-335871-zieuc7vk	7	18	severe	severe	JJ
cord-335871-zieuc7vk	7	19	pulmonary	pulmonary	JJ
cord-335871-zieuc7vk	7	20	edema	edema	NN
cord-335871-zieuc7vk	7	21	and	and	CC
cord-335871-zieuc7vk	7	22	respiratory	respiratory	JJ
cord-335871-zieuc7vk	7	23	failure	failure	NN
cord-335871-zieuc7vk	7	24	.	.	.
cord-335871-zieuc7vk	8	1	While	while	IN
cord-335871-zieuc7vk	8	2	the	the	DT
cord-335871-zieuc7vk	8	3	majority	majority	NN
cord-335871-zieuc7vk	8	4	of	of	IN
cord-335871-zieuc7vk	8	5	those	those	DT
cord-335871-zieuc7vk	8	6	exposed	expose	VBN
cord-335871-zieuc7vk	8	7	have	have	VBP
cord-335871-zieuc7vk	8	8	minor	minor	JJ
cord-335871-zieuc7vk	8	9	symptoms	symptom	NNS
cord-335871-zieuc7vk	8	10	and	and	CC
cord-335871-zieuc7vk	8	11	recover	recover	VB
cord-335871-zieuc7vk	8	12	with	with	IN
cord-335871-zieuc7vk	8	13	little	little	JJ
cord-335871-zieuc7vk	8	14	morbidity	morbidity	NN
cord-335871-zieuc7vk	8	15	,	,	,
cord-335871-zieuc7vk	8	16	an	an	DT
cord-335871-zieuc7vk	8	17	estimated	estimate	VBN
cord-335871-zieuc7vk	8	18	500,000	500,000	CD
cord-335871-zieuc7vk	8	19	people	people	NNS
cord-335871-zieuc7vk	8	20	succumb	succumb	VBP
cord-335871-zieuc7vk	8	21	to	to	IN
cord-335871-zieuc7vk	8	22	IAV	IAV	NNP
cord-335871-zieuc7vk	8	23	-	-	HYPH
cord-335871-zieuc7vk	8	24	related	relate	VBN
cord-335871-zieuc7vk	8	25	complications	complication	NNS
cord-335871-zieuc7vk	8	26	each	each	DT
cord-335871-zieuc7vk	8	27	year	year	NN
cord-335871-zieuc7vk	8	28	worldwide	worldwide	RB
cord-335871-zieuc7vk	8	29	.	.	.
cord-335871-zieuc7vk	9	1	In	in	IN
cord-335871-zieuc7vk	9	2	these	these	DT
cord-335871-zieuc7vk	9	3	severe	severe	JJ
cord-335871-zieuc7vk	9	4	cases	case	NNS
cord-335871-zieuc7vk	9	5	,	,	,
cord-335871-zieuc7vk	9	6	an	an	DT
cord-335871-zieuc7vk	9	7	exaggerated	exaggerated	JJ
cord-335871-zieuc7vk	9	8	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	9	9	response	response	NN
cord-335871-zieuc7vk	9	10	,	,	,
cord-335871-zieuc7vk	9	11	known	know	VBN
cord-335871-zieuc7vk	9	12	as	as	IN
cord-335871-zieuc7vk	9	13	“	"	``
cord-335871-zieuc7vk	9	14	cytokine	cytokine	NN
cord-335871-zieuc7vk	9	15	storm	storm	NN
cord-335871-zieuc7vk	9	16	”	"	''
cord-335871-zieuc7vk	9	17	,	,	,
cord-335871-zieuc7vk	9	18	occurs	occur	VBZ
cord-335871-zieuc7vk	9	19	which	which	WDT
cord-335871-zieuc7vk	9	20	results	result	VBZ
cord-335871-zieuc7vk	9	21	in	in	IN
cord-335871-zieuc7vk	9	22	damage	damage	NN
cord-335871-zieuc7vk	9	23	to	to	IN
cord-335871-zieuc7vk	9	24	the	the	DT
cord-335871-zieuc7vk	9	25	respiratory	respiratory	JJ
cord-335871-zieuc7vk	9	26	epithelial	epithelial	JJ
cord-335871-zieuc7vk	9	27	barrier	barrier	NN
cord-335871-zieuc7vk	9	28	and	and	CC
cord-335871-zieuc7vk	9	29	development	development	NN
cord-335871-zieuc7vk	9	30	of	of	IN
cord-335871-zieuc7vk	9	31	acute	acute	JJ
cord-335871-zieuc7vk	9	32	respiratory	respiratory	JJ
cord-335871-zieuc7vk	9	33	distress	distress	NN
cord-335871-zieuc7vk	9	34	syndrome	syndrome	NN
cord-335871-zieuc7vk	9	35	(	(	-LRB-
cord-335871-zieuc7vk	9	36	ARDS	ARDS	NNP
cord-335871-zieuc7vk	9	37	)	)	-RRB-
cord-335871-zieuc7vk	9	38	.	.	.
cord-335871-zieuc7vk	10	1	Data	datum	NNS
cord-335871-zieuc7vk	10	2	from	from	IN
cord-335871-zieuc7vk	10	3	retrospective	retrospective	JJ
cord-335871-zieuc7vk	10	4	human	human	JJ
cord-335871-zieuc7vk	10	5	studies	study	NNS
cord-335871-zieuc7vk	10	6	as	as	RB
cord-335871-zieuc7vk	10	7	well	well	RB
cord-335871-zieuc7vk	10	8	as	as	IN
cord-335871-zieuc7vk	10	9	experimental	experimental	JJ
cord-335871-zieuc7vk	10	10	animal	animal	NN
cord-335871-zieuc7vk	10	11	models	model	NNS
cord-335871-zieuc7vk	10	12	of	of	IN
cord-335871-zieuc7vk	10	13	influenza	influenza	NN
cord-335871-zieuc7vk	10	14	virus	virus	NN
cord-335871-zieuc7vk	10	15	infection	infection	NN
cord-335871-zieuc7vk	10	16	highlight	highlight	VBP
cord-335871-zieuc7vk	10	17	the	the	DT
cord-335871-zieuc7vk	10	18	fine	fine	JJ
cord-335871-zieuc7vk	10	19	line	line	NN
cord-335871-zieuc7vk	10	20	between	between	IN
cord-335871-zieuc7vk	10	21	an	an	DT
cord-335871-zieuc7vk	10	22	excessive	excessive	JJ
cord-335871-zieuc7vk	10	23	and	and	CC
cord-335871-zieuc7vk	10	24	an	an	DT
cord-335871-zieuc7vk	10	25	inadequate	inadequate	JJ
cord-335871-zieuc7vk	10	26	immune	immune	JJ
cord-335871-zieuc7vk	10	27	response	response	NN
cord-335871-zieuc7vk	10	28	,	,	,
cord-335871-zieuc7vk	10	29	where	where	WRB
cord-335871-zieuc7vk	10	30	the	the	DT
cord-335871-zieuc7vk	10	31	host	host	NN
cord-335871-zieuc7vk	10	32	response	response	NN
cord-335871-zieuc7vk	10	33	must	must	MD
cord-335871-zieuc7vk	10	34	balance	balance	VB
cord-335871-zieuc7vk	10	35	viral	viral	JJ
cord-335871-zieuc7vk	10	36	clearance	clearance	NN
cord-335871-zieuc7vk	10	37	with	with	IN
cord-335871-zieuc7vk	10	38	exuberant	exuberant	JJ
cord-335871-zieuc7vk	10	39	inflammation	inflammation	NN
cord-335871-zieuc7vk	10	40	.	.	.
cord-335871-zieuc7vk	11	1	Current	current	JJ
cord-335871-zieuc7vk	11	2	pharmacological	pharmacological	JJ
cord-335871-zieuc7vk	11	3	modulators	modulator	NNS
cord-335871-zieuc7vk	11	4	of	of	IN
cord-335871-zieuc7vk	11	5	inflammation	inflammation	NN
cord-335871-zieuc7vk	11	6	,	,	,
cord-335871-zieuc7vk	11	7	including	include	VBG
cord-335871-zieuc7vk	11	8	corticosteroids	corticosteroid	NNS
cord-335871-zieuc7vk	11	9	and	and	CC
cord-335871-zieuc7vk	11	10	statins	statin	NNS
cord-335871-zieuc7vk	11	11	,	,	,
cord-335871-zieuc7vk	11	12	have	have	VBP
cord-335871-zieuc7vk	11	13	not	not	RB
cord-335871-zieuc7vk	11	14	been	be	VBN
cord-335871-zieuc7vk	11	15	successful	successful	JJ
cord-335871-zieuc7vk	11	16	in	in	IN
cord-335871-zieuc7vk	11	17	improving	improve	VBG
cord-335871-zieuc7vk	11	18	outcomes	outcome	NNS
cord-335871-zieuc7vk	11	19	during	during	IN
cord-335871-zieuc7vk	11	20	influenza	influenza	NN
cord-335871-zieuc7vk	11	21	virus	virus	NN
cord-335871-zieuc7vk	11	22	infection	infection	NN
cord-335871-zieuc7vk	11	23	.	.	.
cord-335871-zieuc7vk	12	1	We	-PRON-	PRP
cord-335871-zieuc7vk	12	2	have	have	VBP
cord-335871-zieuc7vk	12	3	reported	report	VBN
cord-335871-zieuc7vk	12	4	that	that	IN
cord-335871-zieuc7vk	12	5	the	the	DT
cord-335871-zieuc7vk	12	6	amplitude	amplitude	NN
cord-335871-zieuc7vk	12	7	of	of	IN
cord-335871-zieuc7vk	12	8	the	the	DT
cord-335871-zieuc7vk	12	9	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	12	10	response	response	NN
cord-335871-zieuc7vk	12	11	is	be	VBZ
cord-335871-zieuc7vk	12	12	regulated	regulate	VBN
cord-335871-zieuc7vk	12	13	by	by	IN
cord-335871-zieuc7vk	12	14	Linear	Linear	NNP
cord-335871-zieuc7vk	12	15	Ubiquitin	Ubiquitin	NNP
cord-335871-zieuc7vk	12	16	Assembly	Assembly	NNP
cord-335871-zieuc7vk	12	17	Complex	Complex	NNP
cord-335871-zieuc7vk	12	18	(	(	-LRB-
cord-335871-zieuc7vk	12	19	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	12	20	)	)	-RRB-
cord-335871-zieuc7vk	12	21	activity	activity	NN
cord-335871-zieuc7vk	12	22	and	and	CC
cord-335871-zieuc7vk	12	23	that	that	IN
cord-335871-zieuc7vk	12	24	dampening	dampening	NN
cord-335871-zieuc7vk	12	25	of	of	IN
cord-335871-zieuc7vk	12	26	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	12	27	activity	activity	NN
cord-335871-zieuc7vk	12	28	is	be	VBZ
cord-335871-zieuc7vk	12	29	protective	protective	JJ
cord-335871-zieuc7vk	12	30	during	during	IN
cord-335871-zieuc7vk	12	31	severe	severe	JJ
cord-335871-zieuc7vk	12	32	influenza	influenza	NN
cord-335871-zieuc7vk	12	33	virus	virus	NN
cord-335871-zieuc7vk	12	34	infection	infection	NN
cord-335871-zieuc7vk	12	35	.	.	.
cord-335871-zieuc7vk	13	1	Therapeutic	therapeutic	JJ
cord-335871-zieuc7vk	13	2	modulation	modulation	NN
cord-335871-zieuc7vk	13	3	of	of	IN
cord-335871-zieuc7vk	13	4	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	13	5	activity	activity	NN
cord-335871-zieuc7vk	13	6	may	may	MD
cord-335871-zieuc7vk	13	7	be	be	VB
cord-335871-zieuc7vk	13	8	crucial	crucial	JJ
cord-335871-zieuc7vk	13	9	to	to	TO
cord-335871-zieuc7vk	13	10	improve	improve	VB
cord-335871-zieuc7vk	13	11	outcomes	outcome	NNS
cord-335871-zieuc7vk	13	12	during	during	IN
cord-335871-zieuc7vk	13	13	severe	severe	JJ
cord-335871-zieuc7vk	13	14	influenza	influenza	NN
cord-335871-zieuc7vk	13	15	virus	virus	NN
cord-335871-zieuc7vk	13	16	infection	infection	NN
cord-335871-zieuc7vk	13	17	,	,	,
cord-335871-zieuc7vk	13	18	as	as	IN
cord-335871-zieuc7vk	13	19	it	-PRON-	PRP
cord-335871-zieuc7vk	13	20	functions	function	VBZ
cord-335871-zieuc7vk	13	21	as	as	IN
cord-335871-zieuc7vk	13	22	a	a	DT
cord-335871-zieuc7vk	13	23	molecular	molecular	JJ
cord-335871-zieuc7vk	13	24	rheostat	rheostat	NN
cord-335871-zieuc7vk	13	25	of	of	IN
cord-335871-zieuc7vk	13	26	the	the	DT
cord-335871-zieuc7vk	13	27	host	host	NN
cord-335871-zieuc7vk	13	28	response	response	NN
cord-335871-zieuc7vk	13	29	.	.	.
cord-335871-zieuc7vk	14	1	Here	here	RB
cord-335871-zieuc7vk	14	2	we	-PRON-	PRP
cord-335871-zieuc7vk	14	3	review	review	VBP
cord-335871-zieuc7vk	14	4	the	the	DT
cord-335871-zieuc7vk	14	5	evidence	evidence	NN
cord-335871-zieuc7vk	14	6	for	for	IN
cord-335871-zieuc7vk	14	7	modulating	modulate	VBG
cord-335871-zieuc7vk	14	8	inflammation	inflammation	NN
cord-335871-zieuc7vk	14	9	to	to	TO
cord-335871-zieuc7vk	14	10	ameliorate	ameliorate	VB
cord-335871-zieuc7vk	14	11	influenza	influenza	NN
cord-335871-zieuc7vk	14	12	virus	virus	NN
cord-335871-zieuc7vk	14	13	infection	infection	NN
cord-335871-zieuc7vk	14	14	-	-	HYPH
cord-335871-zieuc7vk	14	15	induced	induce	VBN
cord-335871-zieuc7vk	14	16	lung	lung	NN
cord-335871-zieuc7vk	14	17	injury	injury	NN
cord-335871-zieuc7vk	14	18	,	,	,
cord-335871-zieuc7vk	14	19	data	datum	NNS
cord-335871-zieuc7vk	14	20	on	on	IN
cord-335871-zieuc7vk	14	21	current	current	JJ
cord-335871-zieuc7vk	14	22	anti	anti	JJ
cord-335871-zieuc7vk	14	23	-	-	JJ
cord-335871-zieuc7vk	14	24	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	14	25	strategies	strategy	NNS
cord-335871-zieuc7vk	14	26	,	,	,
cord-335871-zieuc7vk	14	27	and	and	CC
cord-335871-zieuc7vk	14	28	potential	potential	JJ
cord-335871-zieuc7vk	14	29	new	new	JJ
cord-335871-zieuc7vk	14	30	avenues	avenue	NNS
cord-335871-zieuc7vk	14	31	to	to	TO
cord-335871-zieuc7vk	14	32	target	target	VB
cord-335871-zieuc7vk	14	33	viral	viral	JJ
cord-335871-zieuc7vk	14	34	inflammation	inflammation	NN
cord-335871-zieuc7vk	14	35	and	and	CC
cord-335871-zieuc7vk	14	36	improve	improve	VB
cord-335871-zieuc7vk	14	37	outcomes	outcome	NNS
cord-335871-zieuc7vk	14	38	.	.	.
cord-335871-zieuc7vk	15	1	Tratamiento	Tratamiento	NNP
cord-335871-zieuc7vk	15	2	dirigido	dirigido	NNP
cord-335871-zieuc7vk	15	3	al	al	NNP
cord-335871-zieuc7vk	15	4	complejo	complejo	NNP
cord-335871-zieuc7vk	15	5	de	de	FW
cord-335871-zieuc7vk	15	6	ensamblaje	ensamblaje	NNP
cord-335871-zieuc7vk	15	7	de	de	NNP
cord-335871-zieuc7vk	15	8	cadenas	cadenas	NNP
cord-335871-zieuc7vk	15	9	lineales	lineales	NNP
cord-335871-zieuc7vk	15	10	de	de	NNP
cord-335871-zieuc7vk	15	11	ubiquitina	ubiquitina	NNP
cord-335871-zieuc7vk	15	12	para	para	NNP
cord-335871-zieuc7vk	16	1	modular	modular	NNP
cord-335871-zieuc7vk	16	2	la	la	NNP
cord-335871-zieuc7vk	17	1	respuesta	respuesta	NNP
cord-335871-zieuc7vk	17	2	del	del	NNP
cord-335871-zieuc7vk	17	3	huésped	huésped	NNP
cord-335871-zieuc7vk	18	1	y	y	NNP
cord-335871-zieuc7vk	18	2	mejorar	mejorar	NNP
cord-335871-zieuc7vk	19	1	el	el	NNP
cord-335871-zieuc7vk	19	2	daño	daño	NNP
cord-335871-zieuc7vk	20	1	pulmonar	pulmonar	NNP
cord-335871-zieuc7vk	21	1	inducido	inducido	NNP
cord-335871-zieuc7vk	21	2	por	por	NNP
cord-335871-zieuc7vk	21	3	el	el	NNP
cord-335871-zieuc7vk	21	4	virus	virus	NN
cord-335871-zieuc7vk	21	5	de	de	FW
cord-335871-zieuc7vk	21	6	la	la	NNP
cord-335871-zieuc7vk	21	7	gripe	gripe	NN
cord-335871-zieuc7vk	21	8	A	a	NN
cord-335871-zieuc7vk	22	1	La	La	NNP
cord-335871-zieuc7vk	22	2	infección	infección	FW
cord-335871-zieuc7vk	22	3	por	por	FW
cord-335871-zieuc7vk	22	4	el	el	NNP
cord-335871-zieuc7vk	22	5	virus	virus	NN
cord-335871-zieuc7vk	22	6	de	de	NNP
cord-335871-zieuc7vk	22	7	la	la	NNP
cord-335871-zieuc7vk	22	8	gripe	gripe	NN
cord-335871-zieuc7vk	22	9	se	se	FW
cord-335871-zieuc7vk	22	10	caracteriza	caracteriza	FW
cord-335871-zieuc7vk	22	11	por	por	FW
cord-335871-zieuc7vk	22	12	síntomas	síntomas	NNP
cord-335871-zieuc7vk	22	13	que	que	NNP
cord-335871-zieuc7vk	22	14	van	van	NNP
cord-335871-zieuc7vk	22	15	desde	desde	NNP
cord-335871-zieuc7vk	23	1	la	la	NNP
cord-335871-zieuc7vk	23	2	congestión	congestión	NNP
cord-335871-zieuc7vk	23	3	leve	leve	NNP
cord-335871-zieuc7vk	23	4	y	y	NNP
cord-335871-zieuc7vk	23	5	los	los	NNP
cord-335871-zieuc7vk	23	6	dolores	dolores	NNP
cord-335871-zieuc7vk	23	7	corporales	corporales	NNP
cord-335871-zieuc7vk	24	1	hasta	hasta	NNP
cord-335871-zieuc7vk	24	2	el	el	NNP
cord-335871-zieuc7vk	24	3	edema	edema	NNP
cord-335871-zieuc7vk	24	4	pulmonar	pulmonar	NNP
cord-335871-zieuc7vk	24	5	grave	grave	NNP
cord-335871-zieuc7vk	24	6	y	y	NNP
cord-335871-zieuc7vk	24	7	la	la	NNP
cord-335871-zieuc7vk	24	8	insuficiencia	insuficiencia	NNP
cord-335871-zieuc7vk	24	9	respiratoria	respiratoria	NNP
cord-335871-zieuc7vk	24	10	.	.	.
cord-335871-zieuc7vk	25	1	Aunque	Aunque	NNP
cord-335871-zieuc7vk	25	2	que	que	NNP
cord-335871-zieuc7vk	25	3	la	la	FW
cord-335871-zieuc7vk	25	4	mayoría	mayoría	FW
cord-335871-zieuc7vk	25	5	de	de	NNP
cord-335871-zieuc7vk	25	6	las	las	NNP
cord-335871-zieuc7vk	25	7	personas	personas	NNP
cord-335871-zieuc7vk	25	8	expuestas	expuestas	NNP
cord-335871-zieuc7vk	25	9	presentan	presentan	NNP
cord-335871-zieuc7vk	25	10	síntomas	síntomas	NNP
cord-335871-zieuc7vk	25	11	leves	leves	NNP
cord-335871-zieuc7vk	25	12	y	y	NNP
cord-335871-zieuc7vk	25	13	se	se	FW
cord-335871-zieuc7vk	25	14	recuperan	recuperan	NNP
cord-335871-zieuc7vk	25	15	con	con	FW
cord-335871-zieuc7vk	25	16	poca	poca	FW
cord-335871-zieuc7vk	25	17	morbilidad	morbilidad	NNP
cord-335871-zieuc7vk	25	18	,	,	,
cord-335871-zieuc7vk	26	1	se	se	NNP
cord-335871-zieuc7vk	26	2	estima	estima	NNP
cord-335871-zieuc7vk	26	3	que	que	NNP
cord-335871-zieuc7vk	26	4	cada	cada	NNP
cord-335871-zieuc7vk	26	5	año	año	NNP
cord-335871-zieuc7vk	27	1	500	500	CD
cord-335871-zieuc7vk	27	2	000	000	CD
cord-335871-zieuc7vk	27	3	personas	persona	NNS
cord-335871-zieuc7vk	27	4	en	en	FW
cord-335871-zieuc7vk	27	5	todo	todo	FW
cord-335871-zieuc7vk	27	6	el	el	NNP
cord-335871-zieuc7vk	27	7	mundo	mundo	NNP
cord-335871-zieuc7vk	27	8	fallecen	fallecen	NNP
cord-335871-zieuc7vk	27	9	por	por	NNP
cord-335871-zieuc7vk	27	10	las	las	NNP
cord-335871-zieuc7vk	27	11	complicaciones	complicaciones	NNP
cord-335871-zieuc7vk	27	12	relacionadas	relacionadas	NNP
cord-335871-zieuc7vk	27	13	con	con	NNP
cord-335871-zieuc7vk	27	14	esta	esta	NNP
cord-335871-zieuc7vk	27	15	infección	infección	NNP
cord-335871-zieuc7vk	27	16	.	.	.
cord-335871-zieuc7vk	28	1	En	en	IN
cord-335871-zieuc7vk	28	2	estos	estos	FW
cord-335871-zieuc7vk	28	3	casos	casos	NNP
cord-335871-zieuc7vk	28	4	graves	grave	NNS
cord-335871-zieuc7vk	28	5	,	,	,
cord-335871-zieuc7vk	28	6	se	se	FW
cord-335871-zieuc7vk	28	7	produce	produce	VB
cord-335871-zieuc7vk	28	8	una	una	NNP
cord-335871-zieuc7vk	28	9	respuesta	respuesta	FW
cord-335871-zieuc7vk	28	10	inflamatoria	inflamatoria	FW
cord-335871-zieuc7vk	28	11	exagerada	exagerada	NNP
cord-335871-zieuc7vk	28	12	,	,	,
cord-335871-zieuc7vk	28	13	conocida	conocida	NNP
cord-335871-zieuc7vk	28	14	como	como	NNP
cord-335871-zieuc7vk	28	15	"	"	``
cord-335871-zieuc7vk	28	16	tormenta	tormenta	NNP
cord-335871-zieuc7vk	28	17	de	de	FW
cord-335871-zieuc7vk	28	18	citoquinas	citoquinas	NNP
cord-335871-zieuc7vk	28	19	"	"	''
cord-335871-zieuc7vk	28	20	,	,	,
cord-335871-zieuc7vk	28	21	que	que	NNP
cord-335871-zieuc7vk	28	22	causa	causa	FW
cord-335871-zieuc7vk	28	23	daños	daños	NNP
cord-335871-zieuc7vk	29	1	en	en	IN
cord-335871-zieuc7vk	29	2	la	la	NNP
cord-335871-zieuc7vk	29	3	barrera	barrera	NNP
cord-335871-zieuc7vk	30	1	epitelial	epitelial	NNP
cord-335871-zieuc7vk	30	2	respiratoria	respiratoria	NNP
cord-335871-zieuc7vk	31	1	y	y	NNP
cord-335871-zieuc7vk	31	2	el	el	NNP
cord-335871-zieuc7vk	31	3	desarrollo	desarrollo	NNP
cord-335871-zieuc7vk	31	4	del	del	NNP
cord-335871-zieuc7vk	31	5	síndrome	síndrome	NNP
cord-335871-zieuc7vk	31	6	de	de	NNP
cord-335871-zieuc7vk	31	7	distrés	distrés	NNP
cord-335871-zieuc7vk	31	8	respiratorio	respiratorio	NNP
cord-335871-zieuc7vk	31	9	agudo	agudo	NNP
cord-335871-zieuc7vk	31	10	(	(	-LRB-
cord-335871-zieuc7vk	31	11	SDRA	SDRA	NNP
cord-335871-zieuc7vk	31	12	)	)	-RRB-
cord-335871-zieuc7vk	31	13	.	.	.
cord-335871-zieuc7vk	32	1	Los	Los	NNP
cord-335871-zieuc7vk	32	2	datos	datos	NNP
cord-335871-zieuc7vk	32	3	de	de	NNP
cord-335871-zieuc7vk	32	4	estudios	estudios	NNP
cord-335871-zieuc7vk	32	5	retrospectivos	retrospectivos	NNP
cord-335871-zieuc7vk	33	1	en	en	IN
cord-335871-zieuc7vk	33	2	humanos	humanos	NNP
cord-335871-zieuc7vk	34	1	,	,	,
cord-335871-zieuc7vk	34	2	así	así	NNP
cord-335871-zieuc7vk	34	3	como	como	NNP
cord-335871-zieuc7vk	34	4	de	de	NNP
cord-335871-zieuc7vk	34	5	modelos	modelos	NNP
cord-335871-zieuc7vk	34	6	animales	animales	NNP
cord-335871-zieuc7vk	34	7	experimentales	experimentales	NNP
cord-335871-zieuc7vk	34	8	de	de	NNP
cord-335871-zieuc7vk	34	9	infección	infección	FW
cord-335871-zieuc7vk	34	10	por	por	FW
cord-335871-zieuc7vk	34	11	el	el	NNP
cord-335871-zieuc7vk	34	12	virus	virus	NN
cord-335871-zieuc7vk	34	13	de	de	NNP
cord-335871-zieuc7vk	34	14	la	la	NNP
cord-335871-zieuc7vk	34	15	gripe	gripe	NNP
cord-335871-zieuc7vk	34	16	,	,	,
cord-335871-zieuc7vk	34	17	resaltan	resaltan	NNP
cord-335871-zieuc7vk	34	18	la	la	NNP
cord-335871-zieuc7vk	34	19	delgada	delgada	NNP
cord-335871-zieuc7vk	34	20	línea	línea	NNP
cord-335871-zieuc7vk	34	21	que	que	NNP
cord-335871-zieuc7vk	34	22	existe	existe	FW
cord-335871-zieuc7vk	34	23	entre	entre	FW
cord-335871-zieuc7vk	34	24	una	una	FW
cord-335871-zieuc7vk	34	25	respuesta	respuesta	NNP
cord-335871-zieuc7vk	34	26	inmune	inmune	NNP
cord-335871-zieuc7vk	34	27	excesiva	excesiva	NNP
cord-335871-zieuc7vk	35	1	y	y	NNP
cord-335871-zieuc7vk	35	2	una	una	NNP
cord-335871-zieuc7vk	35	3	inadecuada	inadecuada	NNP
cord-335871-zieuc7vk	35	4	,	,	,
cord-335871-zieuc7vk	35	5	cuando	cuando	NNP
cord-335871-zieuc7vk	36	1	la	la	NNP
cord-335871-zieuc7vk	37	1	respuesta	respuesta	NNP
cord-335871-zieuc7vk	37	2	del	del	NNP
cord-335871-zieuc7vk	37	3	huésped	huésped	NNP
cord-335871-zieuc7vk	38	1	debe	debe	NNP
cord-335871-zieuc7vk	38	2	mantener	mantener	FW
cord-335871-zieuc7vk	38	3	el	el	NNP
cord-335871-zieuc7vk	38	4	equilibrio	equilibrio	NNP
cord-335871-zieuc7vk	38	5	entre	entre	NNP
cord-335871-zieuc7vk	38	6	el	el	NNP
cord-335871-zieuc7vk	38	7	aclaramiento	aclaramiento	NNP
cord-335871-zieuc7vk	38	8	viral	viral	NNP
cord-335871-zieuc7vk	38	9	y	y	NNP
cord-335871-zieuc7vk	38	10	la	la	NNP
cord-335871-zieuc7vk	39	1	Introduction	Introduction	NNP
cord-335871-zieuc7vk	39	2	Seasonal	seasonal	JJ
cord-335871-zieuc7vk	39	3	influenza	influenza	NN
cord-335871-zieuc7vk	39	4	A	a	DT
cord-335871-zieuc7vk	39	5	viral	viral	JJ
cord-335871-zieuc7vk	39	6	infection	infection	NN
cord-335871-zieuc7vk	39	7	affects	affect	VBZ
cord-335871-zieuc7vk	39	8	a	a	DT
cord-335871-zieuc7vk	39	9	significant	significant	JJ
cord-335871-zieuc7vk	39	10	proportion	proportion	NN
cord-335871-zieuc7vk	39	11	of	of	IN
cord-335871-zieuc7vk	39	12	the	the	DT
cord-335871-zieuc7vk	39	13	population	population	NN
cord-335871-zieuc7vk	39	14	worldwide	worldwide	RB
cord-335871-zieuc7vk	39	15	,	,	,
cord-335871-zieuc7vk	39	16	with	with	IN
cord-335871-zieuc7vk	39	17	an	an	DT
cord-335871-zieuc7vk	39	18	estimated	estimate	VBN
cord-335871-zieuc7vk	39	19	500,000	500,000	CD
cord-335871-zieuc7vk	39	20	people	people	NNS
cord-335871-zieuc7vk	39	21	succumbing	succumb	VBG
cord-335871-zieuc7vk	39	22	to	to	IN
cord-335871-zieuc7vk	39	23	IAV	IAV	NNP
cord-335871-zieuc7vk	39	24	-	-	HYPH
cord-335871-zieuc7vk	39	25	related	relate	VBN
cord-335871-zieuc7vk	39	26	complications	complication	NNS
cord-335871-zieuc7vk	39	27	each	each	DT
cord-335871-zieuc7vk	39	28	year	year	NN
cord-335871-zieuc7vk	39	29	.	.	.
cord-335871-zieuc7vk	40	1	While	while	IN
cord-335871-zieuc7vk	40	2	most	most	JJS
cord-335871-zieuc7vk	40	3	patients	patient	NNS
cord-335871-zieuc7vk	40	4	infected	infect	VBN
cord-335871-zieuc7vk	40	5	with	with	IN
cord-335871-zieuc7vk	40	6	influenza	influenza	NN
cord-335871-zieuc7vk	40	7	A	a	DT
cord-335871-zieuc7vk	40	8	virus	virus	NN
cord-335871-zieuc7vk	40	9	(	(	-LRB-
cord-335871-zieuc7vk	40	10	IAV	iav	NN
cord-335871-zieuc7vk	40	11	)	)	-RRB-
cord-335871-zieuc7vk	40	12	recover	recover	VB
cord-335871-zieuc7vk	40	13	without	without	IN
cord-335871-zieuc7vk	40	14	major	major	JJ
cord-335871-zieuc7vk	40	15	sequelae	sequela	NNS
cord-335871-zieuc7vk	40	16	,	,	,
cord-335871-zieuc7vk	40	17	severe	severe	JJ
cord-335871-zieuc7vk	40	18	viral	viral	JJ
cord-335871-zieuc7vk	40	19	pneumonia	pneumonia	NN
cord-335871-zieuc7vk	40	20	is	be	VBZ
cord-335871-zieuc7vk	40	21	one	one	CD
cord-335871-zieuc7vk	40	22	of	of	IN
cord-335871-zieuc7vk	40	23	the	the	DT
cord-335871-zieuc7vk	40	24	most	most	RBS
cord-335871-zieuc7vk	40	25	common	common	JJ
cord-335871-zieuc7vk	40	26	causes	cause	NNS
cord-335871-zieuc7vk	40	27	of	of	IN
cord-335871-zieuc7vk	40	28	acute	acute	JJ
cord-335871-zieuc7vk	40	29	respiratory	respiratory	JJ
cord-335871-zieuc7vk	40	30	distress	distress	NN
cord-335871-zieuc7vk	40	31	syndrome	syndrome	NN
cord-335871-zieuc7vk	40	32	(	(	-LRB-
cord-335871-zieuc7vk	40	33	ARDS	ARDS	NNP
cord-335871-zieuc7vk	40	34	)	)	-RRB-
cord-335871-zieuc7vk	40	35	[	[	-LRB-
cord-335871-zieuc7vk	40	36	1	1	LS
cord-335871-zieuc7vk	40	37	]	]	-RRB-
cord-335871-zieuc7vk	40	38	[	[	-LRB-
cord-335871-zieuc7vk	40	39	2	2	CD
cord-335871-zieuc7vk	40	40	]	]	-RRB-
cord-335871-zieuc7vk	40	41	[	[	-LRB-
cord-335871-zieuc7vk	40	42	3	3	CD
cord-335871-zieuc7vk	40	43	]	]	-RRB-
cord-335871-zieuc7vk	40	44	[	[	-LRB-
cord-335871-zieuc7vk	40	45	4	4	CD
cord-335871-zieuc7vk	40	46	]	]	-RRB-
cord-335871-zieuc7vk	40	47	.	.	.
cord-335871-zieuc7vk	41	1	Clinically	clinically	RB
cord-335871-zieuc7vk	41	2	,	,	,
cord-335871-zieuc7vk	41	3	ARDS	ARDS	NNP
cord-335871-zieuc7vk	41	4	presents	present	VBZ
cord-335871-zieuc7vk	41	5	with	with	IN
cord-335871-zieuc7vk	41	6	bilateral	bilateral	JJ
cord-335871-zieuc7vk	41	7	pulmonary	pulmonary	NN
cord-335871-zieuc7vk	41	8	infiltrates	infiltrate	NNS
cord-335871-zieuc7vk	41	9	,	,	,
cord-335871-zieuc7vk	41	10	hypoxemia	hypoxemia	NN
cord-335871-zieuc7vk	41	11	,	,	,
cord-335871-zieuc7vk	41	12	pulmonary	pulmonary	JJ
cord-335871-zieuc7vk	41	13	edema	edema	NN
cord-335871-zieuc7vk	41	14	and	and	CC
cord-335871-zieuc7vk	41	15	widespread	widespread	JJ
cord-335871-zieuc7vk	41	16	lung	lung	NN
cord-335871-zieuc7vk	41	17	inflammation	inflammation	NN
cord-335871-zieuc7vk	41	18	that	that	WDT
cord-335871-zieuc7vk	41	19	lead	lead	VBP
cord-335871-zieuc7vk	41	20	to	to	IN
cord-335871-zieuc7vk	41	21	high	high	JJ
cord-335871-zieuc7vk	41	22	mortality	mortality	NN
cord-335871-zieuc7vk	41	23	rates	rate	NNS
cord-335871-zieuc7vk	41	24	due	due	JJ
cord-335871-zieuc7vk	41	25	respiratory	respiratory	NN
cord-335871-zieuc7vk	41	26	and	and	CC
cord-335871-zieuc7vk	41	27	to	to	IN
cord-335871-zieuc7vk	41	28	multiple	multiple	JJ
cord-335871-zieuc7vk	41	29	organ	organ	NN
cord-335871-zieuc7vk	41	30	failure	failure	NN
cord-335871-zieuc7vk	41	31	[	[	-LRB-
cord-335871-zieuc7vk	41	32	1	1	CD
cord-335871-zieuc7vk	41	33	,	,	,
cord-335871-zieuc7vk	41	34	[	[	-LRB-
cord-335871-zieuc7vk	41	35	4	4	CD
cord-335871-zieuc7vk	41	36	]	]	-RRB-
cord-335871-zieuc7vk	41	37	[	[	-LRB-
cord-335871-zieuc7vk	41	38	5	5	CD
cord-335871-zieuc7vk	41	39	]	]	-RRB-
cord-335871-zieuc7vk	41	40	[	[	-LRB-
cord-335871-zieuc7vk	41	41	6	6	CD
cord-335871-zieuc7vk	41	42	]	]	-RRB-
cord-335871-zieuc7vk	41	43	.	.	.
cord-335871-zieuc7vk	42	1	ARDS	ARDS	NNP
cord-335871-zieuc7vk	42	2	patients	patient	NNS
cord-335871-zieuc7vk	42	3	can	can	MD
cord-335871-zieuc7vk	42	4	be	be	VB
cord-335871-zieuc7vk	42	5	sub	sub	NN
cord-335871-zieuc7vk	42	6	-	-	JJ
cord-335871-zieuc7vk	42	7	grouped	group	VBN
cord-335871-zieuc7vk	42	8	based	base	VBN
cord-335871-zieuc7vk	42	9	on	on	IN
cord-335871-zieuc7vk	42	10	the	the	DT
cord-335871-zieuc7vk	42	11	severity	severity	NN
cord-335871-zieuc7vk	42	12	of	of	IN
cord-335871-zieuc7vk	42	13	the	the	DT
cord-335871-zieuc7vk	42	14	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	42	15	response	response	NN
cord-335871-zieuc7vk	42	16	,	,	,
cord-335871-zieuc7vk	42	17	where	where	WRB
cord-335871-zieuc7vk	42	18	patients	patient	NNS
cord-335871-zieuc7vk	42	19	with	with	IN
cord-335871-zieuc7vk	42	20	hyper	hyper	JJ
cord-335871-zieuc7vk	42	21	-	-	NN
cord-335871-zieuc7vk	42	22	inflammation	inflammation	NN
cord-335871-zieuc7vk	42	23	have	have	VBP
cord-335871-zieuc7vk	42	24	worse	bad	JJR
cord-335871-zieuc7vk	42	25	clinical	clinical	JJ
cord-335871-zieuc7vk	42	26	outcomes	outcome	NNS
cord-335871-zieuc7vk	42	27	,	,	,
cord-335871-zieuc7vk	42	28	spending	spend	VBG
cord-335871-zieuc7vk	42	29	more	more	JJR
cord-335871-zieuc7vk	42	30	days	day	NNS
cord-335871-zieuc7vk	42	31	on	on	IN
cord-335871-zieuc7vk	42	32	mechanical	mechanical	JJ
cord-335871-zieuc7vk	42	33	ventilation	ventilation	NN
cord-335871-zieuc7vk	42	34	,	,	,
cord-335871-zieuc7vk	42	35	experiencing	experience	VBG
cord-335871-zieuc7vk	42	36	increased	increase	VBN
cord-335871-zieuc7vk	42	37	incidence	incidence	NN
cord-335871-zieuc7vk	42	38	of	of	IN
cord-335871-zieuc7vk	42	39	organ	organ	NN
cord-335871-zieuc7vk	42	40	failure	failure	NN
cord-335871-zieuc7vk	42	41	and	and	CC
cord-335871-zieuc7vk	42	42	a	a	DT
cord-335871-zieuc7vk	42	43	higher	high	JJR
cord-335871-zieuc7vk	42	44	mortality	mortality	NN
cord-335871-zieuc7vk	42	45	rate	rate	NN
cord-335871-zieuc7vk	42	46	compared	compare	VBN
cord-335871-zieuc7vk	42	47	to	to	IN
cord-335871-zieuc7vk	42	48	hypo	hypo	JJ
cord-335871-zieuc7vk	42	49	-	-	HYPH
cord-335871-zieuc7vk	42	50	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	42	51	ARDS	ARDS	NNP
cord-335871-zieuc7vk	42	52	patients	patient	NNS
cord-335871-zieuc7vk	42	53	[	[	-LRB-
cord-335871-zieuc7vk	42	54	7	7	CD
cord-335871-zieuc7vk	42	55	]	]	-RRB-
cord-335871-zieuc7vk	42	56	.	.	.
cord-335871-zieuc7vk	43	1	Impairment	impairment	NN
cord-335871-zieuc7vk	43	2	of	of	IN
cord-335871-zieuc7vk	43	3	gas	gas	NN
cord-335871-zieuc7vk	43	4	exchange	exchange	NN
cord-335871-zieuc7vk	43	5	in	in	IN
cord-335871-zieuc7vk	43	6	IAV	IAV	NNP
cord-335871-zieuc7vk	43	7	-	-	HYPH
cord-335871-zieuc7vk	43	8	induced	induce	VBN
cord-335871-zieuc7vk	43	9	ARDS	ARDS	NNP
cord-335871-zieuc7vk	43	10	,	,	,
cord-335871-zieuc7vk	43	11	in	in	IN
cord-335871-zieuc7vk	43	12	large	large	JJ
cord-335871-zieuc7vk	43	13	part	part	NN
cord-335871-zieuc7vk	43	14	,	,	,
cord-335871-zieuc7vk	43	15	is	be	VBZ
cord-335871-zieuc7vk	43	16	due	due	JJ
cord-335871-zieuc7vk	43	17	to	to	IN
cord-335871-zieuc7vk	43	18	damage	damage	NN
cord-335871-zieuc7vk	43	19	to	to	IN
cord-335871-zieuc7vk	43	20	the	the	DT
cord-335871-zieuc7vk	43	21	respiratory	respiratory	JJ
cord-335871-zieuc7vk	43	22	epithelial	epithelial	JJ
cord-335871-zieuc7vk	43	23	barrier	barrier	NN
cord-335871-zieuc7vk	43	24	and	and	CC
cord-335871-zieuc7vk	43	25	edema	edema	NN
cord-335871-zieuc7vk	43	26	accumulation	accumulation	NN
cord-335871-zieuc7vk	43	27	[	[	-LRB-
cord-335871-zieuc7vk	43	28	1	1	CD
cord-335871-zieuc7vk	43	29	,	,	,
cord-335871-zieuc7vk	43	30	[	[	-LRB-
cord-335871-zieuc7vk	43	31	4	4	CD
cord-335871-zieuc7vk	43	32	]	]	-RRB-
cord-335871-zieuc7vk	43	33	[	[	-LRB-
cord-335871-zieuc7vk	43	34	5	5	CD
cord-335871-zieuc7vk	43	35	]	]	-RRB-
cord-335871-zieuc7vk	43	36	[	[	-LRB-
cord-335871-zieuc7vk	43	37	6	6	CD
cord-335871-zieuc7vk	43	38	]	]	-RRB-
cord-335871-zieuc7vk	43	39	[	[	-LRB-
cord-335871-zieuc7vk	43	40	7	7	CD
cord-335871-zieuc7vk	43	41	]	]	-RRB-
cord-335871-zieuc7vk	43	42	[	[	-LRB-
cord-335871-zieuc7vk	43	43	8	8	CD
cord-335871-zieuc7vk	43	44	]	]	-RRB-
cord-335871-zieuc7vk	43	45	.	.	.
cord-335871-zieuc7vk	44	1	During	during	IN
cord-335871-zieuc7vk	44	2	IAV	IAV	NNP
cord-335871-zieuc7vk	44	3	infection	infection	NN
cord-335871-zieuc7vk	44	4	,	,	,
cord-335871-zieuc7vk	44	5	an	an	DT
cord-335871-zieuc7vk	44	6	exaggerated	exaggerated	JJ
cord-335871-zieuc7vk	44	7	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	44	8	response	response	NN
cord-335871-zieuc7vk	44	9	,	,	,
cord-335871-zieuc7vk	44	10	known	know	VBN
cord-335871-zieuc7vk	44	11	as	as	IN
cord-335871-zieuc7vk	44	12	"	"	``
cord-335871-zieuc7vk	44	13	cytokine	cytokine	NN
cord-335871-zieuc7vk	44	14	storm	storm	NN
cord-335871-zieuc7vk	44	15	"	"	''
cord-335871-zieuc7vk	44	16	,	,	,
cord-335871-zieuc7vk	44	17	can	can	MD
cord-335871-zieuc7vk	44	18	occur	occur	VB
cord-335871-zieuc7vk	44	19	leading	lead	VBG
cord-335871-zieuc7vk	44	20	to	to	IN
cord-335871-zieuc7vk	44	21	the	the	DT
cord-335871-zieuc7vk	44	22	development	development	NN
cord-335871-zieuc7vk	44	23	of	of	IN
cord-335871-zieuc7vk	44	24	hyper	hyper	JJ
cord-335871-zieuc7vk	44	25	-	-	HYPH
cord-335871-zieuc7vk	44	26	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	44	27	ARDS	ARDS	NNP
cord-335871-zieuc7vk	44	28	,	,	,
cord-335871-zieuc7vk	44	29	increasing	increase	VBG
cord-335871-zieuc7vk	44	30	IAV	iav	NN
cord-335871-zieuc7vk	44	31	-	-	HYPH
cord-335871-zieuc7vk	44	32	induced	induce	VBN
cord-335871-zieuc7vk	44	33	morbidity	morbidity	NN
cord-335871-zieuc7vk	44	34	and	and	CC
cord-335871-zieuc7vk	44	35	mortality	mortality	NN
cord-335871-zieuc7vk	44	36	(	(	-LRB-
cord-335871-zieuc7vk	44	37	Figure	figure	NN
cord-335871-zieuc7vk	44	38	1	1	CD
cord-335871-zieuc7vk	44	39	)	)	-RRB-
cord-335871-zieuc7vk	44	40	[	[	-LRB-
cord-335871-zieuc7vk	44	41	4	4	CD
cord-335871-zieuc7vk	44	42	]	]	-RRB-
cord-335871-zieuc7vk	44	43	.	.	.
cord-335871-zieuc7vk	45	1	Post	post	JJ
cord-335871-zieuc7vk	45	2	-	-	JJ
cord-335871-zieuc7vk	45	3	mortem	mortem	JJ
cord-335871-zieuc7vk	45	4	studies	study	NNS
cord-335871-zieuc7vk	45	5	of	of	IN
cord-335871-zieuc7vk	45	6	lungs	lung	NNS
cord-335871-zieuc7vk	45	7	from	from	IN
cord-335871-zieuc7vk	45	8	IAV	IAV	NNP
cord-335871-zieuc7vk	45	9	-	-	HYPH
cord-335871-zieuc7vk	45	10	infected	infect	VBN
cord-335871-zieuc7vk	45	11	patients	patient	NNS
cord-335871-zieuc7vk	45	12	show	show	VBP
cord-335871-zieuc7vk	45	13	extensive	extensive	JJ
cord-335871-zieuc7vk	45	14	diffuse	diffuse	JJ
cord-335871-zieuc7vk	45	15	alveolar	alveolar	NN
cord-335871-zieuc7vk	45	16	damage	damage	NN
cord-335871-zieuc7vk	45	17	characterized	characterize	VBN
cord-335871-zieuc7vk	45	18	by	by	IN
cord-335871-zieuc7vk	45	19	edema	edema	NN
cord-335871-zieuc7vk	45	20	,	,	,
cord-335871-zieuc7vk	45	21	cellular	cellular	JJ
cord-335871-zieuc7vk	45	22	infiltration	infiltration	NN
cord-335871-zieuc7vk	45	23	,	,	,
cord-335871-zieuc7vk	45	24	thickening	thickening	NN
cord-335871-zieuc7vk	45	25	of	of	IN
cord-335871-zieuc7vk	45	26	alveolar	alveolar	JJ
cord-335871-zieuc7vk	45	27	walls	wall	NNS
cord-335871-zieuc7vk	45	28	,	,	,
cord-335871-zieuc7vk	45	29	and	and	CC
cord-335871-zieuc7vk	45	30	necrosis	necrosis	NN
cord-335871-zieuc7vk	45	31	[	[	-LRB-
cord-335871-zieuc7vk	45	32	9	9	CD
cord-335871-zieuc7vk	45	33	]	]	-RRB-
cord-335871-zieuc7vk	45	34	.	.	.
cord-335871-zieuc7vk	46	1	Interestingly	interestingly	RB
cord-335871-zieuc7vk	46	2	,	,	,
cord-335871-zieuc7vk	46	3	a	a	DT
cord-335871-zieuc7vk	46	4	study	study	NN
cord-335871-zieuc7vk	46	5	of	of	IN
cord-335871-zieuc7vk	46	6	critically	critically	RB
cord-335871-zieuc7vk	46	7	ill	ill	JJ
cord-335871-zieuc7vk	46	8	patients	patient	NNS
cord-335871-zieuc7vk	46	9	showed	show	VBD
cord-335871-zieuc7vk	46	10	no	no	DT
cord-335871-zieuc7vk	46	11	differences	difference	NNS
cord-335871-zieuc7vk	46	12	in	in	IN
cord-335871-zieuc7vk	46	13	pulmonary	pulmonary	JJ
cord-335871-zieuc7vk	46	14	viral	viral	JJ
cord-335871-zieuc7vk	46	15	load	load	NN
cord-335871-zieuc7vk	46	16	between	between	IN
cord-335871-zieuc7vk	46	17	those	those	DT
cord-335871-zieuc7vk	46	18	who	who	WP
cord-335871-zieuc7vk	46	19	died	die	VBD
cord-335871-zieuc7vk	46	20	and	and	CC
cord-335871-zieuc7vk	46	21	those	those	DT
cord-335871-zieuc7vk	46	22	who	who	WP
cord-335871-zieuc7vk	46	23	recovered	recover	VBD
cord-335871-zieuc7vk	46	24	,	,	,
cord-335871-zieuc7vk	46	25	while	while	IN
cord-335871-zieuc7vk	46	26	mortality	mortality	NN
cord-335871-zieuc7vk	46	27	directly	directly	RB
cord-335871-zieuc7vk	46	28	correlated	correlate	VBN
cord-335871-zieuc7vk	46	29	with	with	IN
cord-335871-zieuc7vk	46	30	exuberant	exuberant	JJ
cord-335871-zieuc7vk	46	31	inflammation	inflammation	NN
cord-335871-zieuc7vk	46	32	,	,	,
cord-335871-zieuc7vk	46	33	further	further	RB
cord-335871-zieuc7vk	46	34	supporting	support	VBG
cord-335871-zieuc7vk	46	35	a	a	DT
cord-335871-zieuc7vk	46	36	maladaptive	maladaptive	JJ
cord-335871-zieuc7vk	46	37	host	host	NN
cord-335871-zieuc7vk	46	38	response	response	NN
cord-335871-zieuc7vk	46	39	as	as	IN
cord-335871-zieuc7vk	46	40	the	the	DT
cord-335871-zieuc7vk	46	41	major	major	JJ
cord-335871-zieuc7vk	46	42	driver	driver	NN
cord-335871-zieuc7vk	46	43	of	of	IN
cord-335871-zieuc7vk	46	44	IAV	IAV	NNP
cord-335871-zieuc7vk	46	45	-	-	HYPH
cord-335871-zieuc7vk	46	46	induced	induce	VBN
cord-335871-zieuc7vk	46	47	lung	lung	NN
cord-335871-zieuc7vk	46	48	injury	injury	NN
cord-335871-zieuc7vk	46	49	[	[	-LRB-
cord-335871-zieuc7vk	46	50	10	10	CD
cord-335871-zieuc7vk	46	51	]	]	-RRB-
cord-335871-zieuc7vk	46	52	[	[	-LRB-
cord-335871-zieuc7vk	46	53	11	11	CD
cord-335871-zieuc7vk	46	54	]	]	-RRB-
cord-335871-zieuc7vk	46	55	[	[	-LRB-
cord-335871-zieuc7vk	46	56	12	12	CD
cord-335871-zieuc7vk	46	57	]	]	-RRB-
cord-335871-zieuc7vk	46	58	[	[	-LRB-
cord-335871-zieuc7vk	46	59	13	13	CD
cord-335871-zieuc7vk	46	60	]	]	-RRB-
cord-335871-zieuc7vk	47	1	[	[	-LRB-
cord-335871-zieuc7vk	47	2	14	14	CD
cord-335871-zieuc7vk	47	3	]	]	-RRB-
cord-335871-zieuc7vk	47	4	.	.	.
cord-335871-zieuc7vk	48	1	Similar	similar	JJ
cord-335871-zieuc7vk	48	2	observations	observation	NNS
cord-335871-zieuc7vk	48	3	are	be	VBP
cord-335871-zieuc7vk	48	4	being	be	VBG
cord-335871-zieuc7vk	48	5	reported	report	VBN
cord-335871-zieuc7vk	48	6	in	in	IN
cord-335871-zieuc7vk	48	7	patients	patient	NNS
cord-335871-zieuc7vk	48	8	with	with	IN
cord-335871-zieuc7vk	48	9	severe	severe	JJ
cord-335871-zieuc7vk	48	10	coronavirus	coronavirus	NN
cord-335871-zieuc7vk	48	11	disease	disease	NN
cord-335871-zieuc7vk	48	12	(	(	-LRB-
cord-335871-zieuc7vk	48	13	COVID-	covid-	NN
cord-335871-zieuc7vk	48	14	19	19	CD
cord-335871-zieuc7vk	48	15	)	)	-RRB-
cord-335871-zieuc7vk	48	16	,	,	,
cord-335871-zieuc7vk	48	17	where	where	WRB
cord-335871-zieuc7vk	48	18	severe	severe	JJ
cord-335871-zieuc7vk	48	19	lung	lung	NN
cord-335871-zieuc7vk	48	20	damage	damage	NN
cord-335871-zieuc7vk	48	21	is	be	VBZ
cord-335871-zieuc7vk	48	22	associated	associate	VBN
cord-335871-zieuc7vk	48	23	with	with	IN
cord-335871-zieuc7vk	48	24	increased	increase	VBN
cord-335871-zieuc7vk	48	25	pro	pro	JJ
cord-335871-zieuc7vk	48	26	-	-	JJ
cord-335871-zieuc7vk	48	27	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	48	28	cytokines	cytokine	NNS
cord-335871-zieuc7vk	48	29	and	and	CC
cord-335871-zieuc7vk	48	30	respiratory	respiratory	JJ
cord-335871-zieuc7vk	48	31	failure	failure	NN
cord-335871-zieuc7vk	48	32	from	from	IN
cord-335871-zieuc7vk	48	33	ARDS	ARDS	NNP
cord-335871-zieuc7vk	48	34	is	be	VBZ
cord-335871-zieuc7vk	48	35	the	the	DT
cord-335871-zieuc7vk	48	36	leading	leading	JJ
cord-335871-zieuc7vk	48	37	cause	cause	NN
cord-335871-zieuc7vk	48	38	of	of	IN
cord-335871-zieuc7vk	48	39	mortality	mortality	NN
cord-335871-zieuc7vk	48	40	[	[	-LRB-
cord-335871-zieuc7vk	48	41	15	15	CD
cord-335871-zieuc7vk	48	42	,	,	,
cord-335871-zieuc7vk	48	43	16	16	CD
cord-335871-zieuc7vk	48	44	]	]	-RRB-
cord-335871-zieuc7vk	48	45	.	.	.
cord-335871-zieuc7vk	49	1	With	with	IN
cord-335871-zieuc7vk	49	2	no	no	DT
cord-335871-zieuc7vk	49	3	virus	virus	NN
cord-335871-zieuc7vk	49	4	-	-	HYPH
cord-335871-zieuc7vk	49	5	specific	specific	JJ
cord-335871-zieuc7vk	49	6	treatment	treatment	NN
cord-335871-zieuc7vk	49	7	options	option	NNS
cord-335871-zieuc7vk	49	8	currently	currently	RB
cord-335871-zieuc7vk	49	9	validated	validate	VBN
cord-335871-zieuc7vk	49	10	,	,	,
cord-335871-zieuc7vk	49	11	therapies	therapy	NNS
cord-335871-zieuc7vk	49	12	which	which	WDT
cord-335871-zieuc7vk	49	13	target	target	VBP
cord-335871-zieuc7vk	49	14	the	the	DT
cord-335871-zieuc7vk	49	15	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	49	16	response	response	NN
cord-335871-zieuc7vk	49	17	are	be	VBP
cord-335871-zieuc7vk	49	18	currently	currently	RB
cord-335871-zieuc7vk	49	19	being	be	VBG
cord-335871-zieuc7vk	49	20	considered	consider	VBN
cord-335871-zieuc7vk	49	21	for	for	IN
cord-335871-zieuc7vk	49	22	patients	patient	NNS
cord-335871-zieuc7vk	49	23	with	with	IN
cord-335871-zieuc7vk	49	24	severe	severe	JJ
cord-335871-zieuc7vk	49	25	COVID-19	COVID-19	NNP
cord-335871-zieuc7vk	49	26	[	[	-LRB-
cord-335871-zieuc7vk	49	27	17	17	CD
cord-335871-zieuc7vk	49	28	,	,	,
cord-335871-zieuc7vk	49	29	18	18	CD
cord-335871-zieuc7vk	49	30	]	]	-RRB-
cord-335871-zieuc7vk	49	31	.	.	.
cord-335871-zieuc7vk	50	1	However	however	RB
cord-335871-zieuc7vk	50	2	,	,	,
cord-335871-zieuc7vk	50	3	as	as	IN
cord-335871-zieuc7vk	50	4	it	-PRON-	PRP
cord-335871-zieuc7vk	50	5	has	have	VBZ
cord-335871-zieuc7vk	50	6	been	be	VBN
cord-335871-zieuc7vk	50	7	reported	report	VBN
cord-335871-zieuc7vk	50	8	for	for	IN
cord-335871-zieuc7vk	50	9	severe	severe	JJ
cord-335871-zieuc7vk	50	10	IAV	IAV	NNP
cord-335871-zieuc7vk	50	11	infections	infection	NNS
cord-335871-zieuc7vk	50	12	,	,	,
cord-335871-zieuc7vk	50	13	current	current	JJ
cord-335871-zieuc7vk	50	14	antiinflammatory	antiinflammatory	JJ
cord-335871-zieuc7vk	50	15	drugs	drug	NNS
cord-335871-zieuc7vk	50	16	have	have	VBP
cord-335871-zieuc7vk	50	17	pleiotropic	pleiotropic	JJ
cord-335871-zieuc7vk	50	18	effects	effect	NNS
cord-335871-zieuc7vk	50	19	and	and	CC
cord-335871-zieuc7vk	50	20	may	may	MD
cord-335871-zieuc7vk	50	21	lack	lack	VB
cord-335871-zieuc7vk	50	22	the	the	DT
cord-335871-zieuc7vk	50	23	specificity	specificity	NN
cord-335871-zieuc7vk	50	24	needed	need	VBN
cord-335871-zieuc7vk	50	25	to	to	TO
cord-335871-zieuc7vk	50	26	carefully	carefully	RB
cord-335871-zieuc7vk	50	27	calibrate	calibrate	VB
cord-335871-zieuc7vk	50	28	the	the	DT
cord-335871-zieuc7vk	50	29	host	host	NN
cord-335871-zieuc7vk	50	30	response	response	NN
cord-335871-zieuc7vk	50	31	.	.	.
cord-335871-zieuc7vk	51	1	Respiratory	respiratory	JJ
cord-335871-zieuc7vk	51	2	epithelial	epithelial	JJ
cord-335871-zieuc7vk	51	3	cells	cell	NNS
cord-335871-zieuc7vk	51	4	,	,	,
cord-335871-zieuc7vk	51	5	as	as	IN
cord-335871-zieuc7vk	51	6	primary	primary	JJ
cord-335871-zieuc7vk	51	7	targets	target	NNS
cord-335871-zieuc7vk	51	8	for	for	IN
cord-335871-zieuc7vk	51	9	IAV	IAV	NNP
cord-335871-zieuc7vk	51	10	infection	infection	NN
cord-335871-zieuc7vk	51	11	and	and	CC
cord-335871-zieuc7vk	51	12	replication	replication	NN
cord-335871-zieuc7vk	51	13	,	,	,
cord-335871-zieuc7vk	51	14	initiate	initiate	VB
cord-335871-zieuc7vk	51	15	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	51	16	signaling	signal	VBG
cord-335871-zieuc7vk	51	17	[	[	-LRB-
cord-335871-zieuc7vk	51	18	19	19	CD
cord-335871-zieuc7vk	51	19	]	]	-RRB-
cord-335871-zieuc7vk	51	20	[	[	-LRB-
cord-335871-zieuc7vk	51	21	20	20	CD
cord-335871-zieuc7vk	51	22	]	]	-RRB-
cord-335871-zieuc7vk	51	23	[	[	-LRB-
cord-335871-zieuc7vk	51	24	21	21	CD
cord-335871-zieuc7vk	51	25	]	]	-RRB-
cord-335871-zieuc7vk	51	26	[	[	-LRB-
cord-335871-zieuc7vk	51	27	22	22	CD
cord-335871-zieuc7vk	51	28	]	]	-RRB-
cord-335871-zieuc7vk	51	29	.	.	.
cord-335871-zieuc7vk	52	1	In	in	IN
cord-335871-zieuc7vk	52	2	response	response	NN
cord-335871-zieuc7vk	52	3	to	to	IN
cord-335871-zieuc7vk	52	4	respiratory	respiratory	JJ
cord-335871-zieuc7vk	52	5	epithelial	epithelial	NN
cord-335871-zieuc7vk	52	6	derived	derive	VBN
cord-335871-zieuc7vk	52	7	cytokines	cytokine	NNS
cord-335871-zieuc7vk	52	8	,	,	,
cord-335871-zieuc7vk	52	9	innate	innate	JJ
cord-335871-zieuc7vk	52	10	immune	immune	JJ
cord-335871-zieuc7vk	52	11	cells	cell	NNS
cord-335871-zieuc7vk	52	12	,	,	,
cord-335871-zieuc7vk	52	13	such	such	JJ
cord-335871-zieuc7vk	52	14	as	as	IN
cord-335871-zieuc7vk	52	15	neutrophils	neutrophil	NNS
cord-335871-zieuc7vk	52	16	,	,	,
cord-335871-zieuc7vk	52	17	monocyte	monocyte	NNP
cord-335871-zieuc7vk	52	18	-	-	HYPH
cord-335871-zieuc7vk	52	19	derived	derive	VBN
cord-335871-zieuc7vk	52	20	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	52	21	macrophages	macrophage	NNS
cord-335871-zieuc7vk	52	22	,	,	,
cord-335871-zieuc7vk	52	23	and	and	CC
cord-335871-zieuc7vk	52	24	natural	natural	JJ
cord-335871-zieuc7vk	52	25	killer	killer	NN
cord-335871-zieuc7vk	52	26	(	(	-LRB-
cord-335871-zieuc7vk	52	27	NK	NK	NNP
cord-335871-zieuc7vk	52	28	)	)	-RRB-
cord-335871-zieuc7vk	52	29	cells	cell	NNS
cord-335871-zieuc7vk	52	30	are	be	VBP
cord-335871-zieuc7vk	52	31	recruited	recruit	VBN
cord-335871-zieuc7vk	52	32	to	to	IN
cord-335871-zieuc7vk	52	33	the	the	DT
cord-335871-zieuc7vk	52	34	airspace	airspace	NN
cord-335871-zieuc7vk	52	35	[	[	-LRB-
cord-335871-zieuc7vk	52	36	23	23	CD
cord-335871-zieuc7vk	52	37	]	]	-RRB-
cord-335871-zieuc7vk	52	38	.	.	.
cord-335871-zieuc7vk	53	1	Together	together	RB
cord-335871-zieuc7vk	53	2	with	with	IN
cord-335871-zieuc7vk	53	3	tissue	tissue	NN
cord-335871-zieuc7vk	53	4	resident	resident	NN
cord-335871-zieuc7vk	53	5	alveolar	alveolar	NN
cord-335871-zieuc7vk	53	6	macrophages	macrophage	NNS
cord-335871-zieuc7vk	53	7	,	,	,
cord-335871-zieuc7vk	53	8	recruited	recruit	VBN
cord-335871-zieuc7vk	53	9	innate	innate	JJ
cord-335871-zieuc7vk	53	10	immune	immune	JJ
cord-335871-zieuc7vk	53	11	cells	cell	NNS
cord-335871-zieuc7vk	53	12	are	be	VBP
cord-335871-zieuc7vk	53	13	critical	critical	JJ
cord-335871-zieuc7vk	53	14	for	for	IN
cord-335871-zieuc7vk	53	15	control	control	NN
cord-335871-zieuc7vk	53	16	of	of	IN
cord-335871-zieuc7vk	53	17	viral	viral	JJ
cord-335871-zieuc7vk	53	18	replication	replication	NN
cord-335871-zieuc7vk	53	19	through	through	IN
cord-335871-zieuc7vk	53	20	both	both	CC
cord-335871-zieuc7vk	53	21	lysis	lysis	NN
cord-335871-zieuc7vk	53	22	and	and	CC
cord-335871-zieuc7vk	53	23	clearance	clearance	NN
cord-335871-zieuc7vk	53	24	of	of	IN
cord-335871-zieuc7vk	53	25	virus	virus	NN
cord-335871-zieuc7vk	53	26	-	-	HYPH
cord-335871-zieuc7vk	53	27	infected	infect	VBN
cord-335871-zieuc7vk	53	28	cells	cell	NNS
cord-335871-zieuc7vk	53	29	[	[	-LRB-
cord-335871-zieuc7vk	53	30	23	23	CD
cord-335871-zieuc7vk	53	31	]	]	-RRB-
cord-335871-zieuc7vk	53	32	[	[	-LRB-
cord-335871-zieuc7vk	53	33	24	24	CD
cord-335871-zieuc7vk	53	34	]	]	-RRB-
cord-335871-zieuc7vk	53	35	[	[	-LRB-
cord-335871-zieuc7vk	53	36	25	25	CD
cord-335871-zieuc7vk	53	37	]	]	-RRB-
cord-335871-zieuc7vk	53	38	[	[	-LRB-
cord-335871-zieuc7vk	53	39	26	26	CD
cord-335871-zieuc7vk	53	40	]	]	-RRB-
cord-335871-zieuc7vk	53	41	.	.	.
cord-335871-zieuc7vk	54	1	However	however	RB
cord-335871-zieuc7vk	54	2	,	,	,
cord-335871-zieuc7vk	54	3	in	in	IN
cord-335871-zieuc7vk	54	4	addition	addition	NN
cord-335871-zieuc7vk	54	5	to	to	IN
cord-335871-zieuc7vk	54	6	controlling	control	VBG
cord-335871-zieuc7vk	54	7	viral	viral	JJ
cord-335871-zieuc7vk	54	8	spread	spread	NN
cord-335871-zieuc7vk	54	9	,	,	,
cord-335871-zieuc7vk	54	10	innate	innate	JJ
cord-335871-zieuc7vk	54	11	immune	immune	JJ
cord-335871-zieuc7vk	54	12	cells	cell	NNS
cord-335871-zieuc7vk	54	13	contribute	contribute	VBP
cord-335871-zieuc7vk	54	14	to	to	IN
cord-335871-zieuc7vk	54	15	the	the	DT
cord-335871-zieuc7vk	54	16	overproduction	overproduction	NN
cord-335871-zieuc7vk	54	17	of	of	IN
cord-335871-zieuc7vk	54	18	pro	pro	JJ
cord-335871-zieuc7vk	54	19	-	-	JJ
cord-335871-zieuc7vk	54	20	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	54	21	cytokines	cytokine	NNS
cord-335871-zieuc7vk	54	22	that	that	WDT
cord-335871-zieuc7vk	54	23	enhance	enhance	VBP
cord-335871-zieuc7vk	54	24	IAV	iav	NN
cord-335871-zieuc7vk	54	25	-	-	HYPH
cord-335871-zieuc7vk	54	26	induced	induce	VBN
cord-335871-zieuc7vk	54	27	lung	lung	NN
cord-335871-zieuc7vk	54	28	injury	injury	NN
cord-335871-zieuc7vk	54	29	(	(	-LRB-
cord-335871-zieuc7vk	54	30	Figure	figure	NN
cord-335871-zieuc7vk	54	31	2	2	CD
cord-335871-zieuc7vk	54	32	)	)	-RRB-
cord-335871-zieuc7vk	54	33	.	.	.
cord-335871-zieuc7vk	55	1	The	the	DT
cord-335871-zieuc7vk	55	2	pulmonary	pulmonary	JJ
cord-335871-zieuc7vk	55	3	immune	immune	JJ
cord-335871-zieuc7vk	55	4	response	response	NN
cord-335871-zieuc7vk	55	5	must	must	MD
cord-335871-zieuc7vk	55	6	be	be	VB
cord-335871-zieuc7vk	55	7	carefully	carefully	RB
cord-335871-zieuc7vk	55	8	balanced	balance	VBN
cord-335871-zieuc7vk	55	9	,	,	,
cord-335871-zieuc7vk	55	10	simultaneously	simultaneously	RB
cord-335871-zieuc7vk	55	11	promoting	promote	VBG
cord-335871-zieuc7vk	55	12	viral	viral	JJ
cord-335871-zieuc7vk	55	13	clearance	clearance	NN
cord-335871-zieuc7vk	55	14	and	and	CC
cord-335871-zieuc7vk	55	15	limiting	limit	VBG
cord-335871-zieuc7vk	55	16	excessive	excessive	JJ
cord-335871-zieuc7vk	55	17	inflammation	inflammation	NN
cord-335871-zieuc7vk	55	18	to	to	TO
cord-335871-zieuc7vk	55	19	maintain	maintain	VB
cord-335871-zieuc7vk	55	20	proper	proper	JJ
cord-335871-zieuc7vk	55	21	lung	lung	NN
cord-335871-zieuc7vk	55	22	function	function	NN
cord-335871-zieuc7vk	55	23	.	.	.
cord-335871-zieuc7vk	56	1	Findings	finding	NNS
cord-335871-zieuc7vk	56	2	from	from	IN
cord-335871-zieuc7vk	56	3	animal	animal	NN
cord-335871-zieuc7vk	56	4	models	model	NNS
cord-335871-zieuc7vk	56	5	of	of	IN
cord-335871-zieuc7vk	56	6	IAV	IAV	NNP
cord-335871-zieuc7vk	56	7	infection	infection	NN
cord-335871-zieuc7vk	56	8	have	have	VBP
cord-335871-zieuc7vk	56	9	shown	show	VBN
cord-335871-zieuc7vk	56	10	that	that	DT
cord-335871-zieuc7vk	56	11	modulation	modulation	NN
cord-335871-zieuc7vk	56	12	of	of	IN
cord-335871-zieuc7vk	56	13	the	the	DT
cord-335871-zieuc7vk	56	14	host	host	NN
cord-335871-zieuc7vk	56	15	immune	immune	JJ
cord-335871-zieuc7vk	56	16	response	response	NN
cord-335871-zieuc7vk	56	17	is	be	VBZ
cord-335871-zieuc7vk	56	18	associated	associate	VBN
cord-335871-zieuc7vk	56	19	with	with	IN
cord-335871-zieuc7vk	56	20	reduced	reduce	VBN
cord-335871-zieuc7vk	56	21	lung	lung	NN
cord-335871-zieuc7vk	56	22	injury	injury	NN
cord-335871-zieuc7vk	56	23	and	and	CC
cord-335871-zieuc7vk	56	24	improved	improved	JJ
cord-335871-zieuc7vk	56	25	survival	survival	NN
cord-335871-zieuc7vk	56	26	[	[	-LRB-
cord-335871-zieuc7vk	56	27	11	11	CD
cord-335871-zieuc7vk	56	28	,	,	,
cord-335871-zieuc7vk	56	29	14	14	CD
cord-335871-zieuc7vk	56	30	,	,	,
cord-335871-zieuc7vk	56	31	27	27	CD
cord-335871-zieuc7vk	56	32	,	,	,
cord-335871-zieuc7vk	56	33	28	28	CD
cord-335871-zieuc7vk	56	34	]	]	-RRB-
cord-335871-zieuc7vk	56	35	.	.	.
cord-335871-zieuc7vk	57	1	Blockade	blockade	NN
cord-335871-zieuc7vk	57	2	of	of	IN
cord-335871-zieuc7vk	57	3	specific	specific	JJ
cord-335871-zieuc7vk	57	4	immune	immune	JJ
cord-335871-zieuc7vk	57	5	cell	cell	NN
cord-335871-zieuc7vk	57	6	subsets	subset	NNS
cord-335871-zieuc7vk	57	7	has	have	VBZ
cord-335871-zieuc7vk	57	8	been	be	VBN
cord-335871-zieuc7vk	57	9	shown	show	VBN
cord-335871-zieuc7vk	57	10	to	to	TO
cord-335871-zieuc7vk	57	11	improve	improve	VB
cord-335871-zieuc7vk	57	12	outcomes	outcome	NNS
cord-335871-zieuc7vk	57	13	in	in	IN
cord-335871-zieuc7vk	57	14	mouse	mouse	NN
cord-335871-zieuc7vk	57	15	models	model	NNS
cord-335871-zieuc7vk	57	16	of	of	IN
cord-335871-zieuc7vk	57	17	severe	severe	JJ
cord-335871-zieuc7vk	57	18	IAV	IAV	NNP
cord-335871-zieuc7vk	57	19	infection	infection	NN
cord-335871-zieuc7vk	57	20	.	.	.
cord-335871-zieuc7vk	58	1	For	for	IN
cord-335871-zieuc7vk	58	2	example	example	NN
cord-335871-zieuc7vk	58	3	,	,	,
cord-335871-zieuc7vk	58	4	genetic	genetic	JJ
cord-335871-zieuc7vk	58	5	deletion	deletion	NN
cord-335871-zieuc7vk	58	6	of	of	IN
cord-335871-zieuc7vk	58	7	the	the	DT
cord-335871-zieuc7vk	58	8	chemokine	chemokine	NN
cord-335871-zieuc7vk	58	9	receptor	receptor	NN
cord-335871-zieuc7vk	58	10	CCR2	CCR2	NNP
cord-335871-zieuc7vk	58	11	inhibited	inhibit	VBD
cord-335871-zieuc7vk	58	12	the	the	DT
cord-335871-zieuc7vk	58	13	recruitment	recruitment	NN
cord-335871-zieuc7vk	58	14	of	of	IN
cord-335871-zieuc7vk	58	15	monocyte	monocyte	NNP
cord-335871-zieuc7vk	58	16	-	-	HYPH
cord-335871-zieuc7vk	58	17	derived	derive	VBN
cord-335871-zieuc7vk	58	18	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	58	19	macrophages	macrophage	NNS
cord-335871-zieuc7vk	58	20	during	during	IN
cord-335871-zieuc7vk	58	21	IAV	IAV	NNP
cord-335871-zieuc7vk	58	22	infection	infection	NN
cord-335871-zieuc7vk	58	23	and	and	CC
cord-335871-zieuc7vk	58	24	resulted	result	VBD
cord-335871-zieuc7vk	58	25	in	in	IN
cord-335871-zieuc7vk	58	26	reduced	reduce	VBN
cord-335871-zieuc7vk	58	27	lung	lung	NN
cord-335871-zieuc7vk	58	28	injury	injury	NN
cord-335871-zieuc7vk	58	29	with	with	IN
cord-335871-zieuc7vk	58	30	improved	improved	JJ
cord-335871-zieuc7vk	58	31	survival	survival	NN
cord-335871-zieuc7vk	58	32	.	.	.
cord-335871-zieuc7vk	59	1	However	however	RB
cord-335871-zieuc7vk	59	2	,	,	,
cord-335871-zieuc7vk	59	3	loss	loss	NN
cord-335871-zieuc7vk	59	4	of	of	IN
cord-335871-zieuc7vk	59	5	this	this	DT
cord-335871-zieuc7vk	59	6	myeloid	myeloid	JJ
cord-335871-zieuc7vk	59	7	cell	cell	NN
cord-335871-zieuc7vk	59	8	population	population	NN
cord-335871-zieuc7vk	59	9	resulted	result	VBD
cord-335871-zieuc7vk	59	10	in	in	IN
cord-335871-zieuc7vk	59	11	a	a	DT
cord-335871-zieuc7vk	59	12	delay	delay	NN
cord-335871-zieuc7vk	59	13	in	in	IN
cord-335871-zieuc7vk	59	14	viral	viral	JJ
cord-335871-zieuc7vk	59	15	clearance	clearance	NN
cord-335871-zieuc7vk	59	16	[	[	-LRB-
cord-335871-zieuc7vk	59	17	29	29	CD
cord-335871-zieuc7vk	59	18	,	,	,
cord-335871-zieuc7vk	59	19	30	30	CD
cord-335871-zieuc7vk	59	20	]	]	-RRB-
cord-335871-zieuc7vk	59	21	.	.	.
cord-335871-zieuc7vk	60	1	Moreover	moreover	RB
cord-335871-zieuc7vk	60	2	,	,	,
cord-335871-zieuc7vk	60	3	adoptive	adoptive	JJ
cord-335871-zieuc7vk	60	4	transfer	transfer	NN
cord-335871-zieuc7vk	60	5	of	of	IN
cord-335871-zieuc7vk	60	6	NK	NK	NNP
cord-335871-zieuc7vk	60	7	cells	cell	NNS
cord-335871-zieuc7vk	60	8	from	from	IN
cord-335871-zieuc7vk	60	9	IAV	IAV	NNP
cord-335871-zieuc7vk	60	10	-	-	HYPH
cord-335871-zieuc7vk	60	11	infected	infect	VBN
cord-335871-zieuc7vk	60	12	lungs	lung	NNS
cord-335871-zieuc7vk	60	13	,	,	,
cord-335871-zieuc7vk	60	14	as	as	IN
cord-335871-zieuc7vk	60	15	compared	compare	VBN
cord-335871-zieuc7vk	60	16	to	to	IN
cord-335871-zieuc7vk	60	17	NK	NK	NNP
cord-335871-zieuc7vk	60	18	cell	cell	NN
cord-335871-zieuc7vk	60	19	from	from	IN
cord-335871-zieuc7vk	60	20	naïve	naïve	JJ
cord-335871-zieuc7vk	60	21	lungs	lung	NNS
cord-335871-zieuc7vk	60	22	,	,	,
cord-335871-zieuc7vk	60	23	resulted	result	VBD
cord-335871-zieuc7vk	60	24	in	in	IN
cord-335871-zieuc7vk	60	25	increased	increase	VBN
cord-335871-zieuc7vk	60	26	mortality	mortality	NN
cord-335871-zieuc7vk	60	27	of	of	IN
cord-335871-zieuc7vk	60	28	influenzainfected	influenzainfected	JJ
cord-335871-zieuc7vk	60	29	mice	mouse	NNS
cord-335871-zieuc7vk	60	30	[	[	-LRB-
cord-335871-zieuc7vk	60	31	31	31	CD
cord-335871-zieuc7vk	60	32	]	]	-RRB-
cord-335871-zieuc7vk	60	33	,	,	,
cord-335871-zieuc7vk	60	34	suggesting	suggest	VBG
cord-335871-zieuc7vk	60	35	that	that	IN
cord-335871-zieuc7vk	60	36	inflammation	inflammation	NN
cord-335871-zieuc7vk	60	37	-	-	HYPH
cord-335871-zieuc7vk	60	38	dependent	dependent	JJ
cord-335871-zieuc7vk	60	39	activation	activation	NN
cord-335871-zieuc7vk	60	40	,	,	,
cord-335871-zieuc7vk	60	41	rather	rather	RB
cord-335871-zieuc7vk	60	42	than	than	IN
cord-335871-zieuc7vk	60	43	recruitment	recruitment	NN
cord-335871-zieuc7vk	60	44	,	,	,
cord-335871-zieuc7vk	60	45	drives	drive	VBZ
cord-335871-zieuc7vk	60	46	the	the	DT
cord-335871-zieuc7vk	60	47	observed	observed	JJ
cord-335871-zieuc7vk	60	48	pathology	pathology	NN
cord-335871-zieuc7vk	60	49	.	.	.
cord-335871-zieuc7vk	61	1	Taken	take	VBN
cord-335871-zieuc7vk	61	2	together	together	RB
cord-335871-zieuc7vk	61	3	data	datum	NNS
cord-335871-zieuc7vk	61	4	from	from	IN
cord-335871-zieuc7vk	61	5	these	these	DT
cord-335871-zieuc7vk	61	6	animal	animal	NN
cord-335871-zieuc7vk	61	7	models	model	NNS
cord-335871-zieuc7vk	61	8	suggest	suggest	VBP
cord-335871-zieuc7vk	61	9	that	that	IN
cord-335871-zieuc7vk	61	10	the	the	DT
cord-335871-zieuc7vk	61	11	determinant	determinant	NN
cord-335871-zieuc7vk	61	12	of	of	IN
cord-335871-zieuc7vk	61	13	influenza	influenza	NN
cord-335871-zieuc7vk	61	14	severity	severity	NN
cord-335871-zieuc7vk	61	15	be	be	VB
cord-335871-zieuc7vk	61	16	orchestrated	orchestrate	VBN
cord-335871-zieuc7vk	61	17	by	by	IN
cord-335871-zieuc7vk	61	18	respiratory	respiratory	JJ
cord-335871-zieuc7vk	61	19	epithelial	epithelial	JJ
cord-335871-zieuc7vk	61	20	cells	cell	NNS
cord-335871-zieuc7vk	61	21	.	.	.
cord-335871-zieuc7vk	62	1	The	the	DT
cord-335871-zieuc7vk	62	2	linear	linear	JJ
cord-335871-zieuc7vk	62	3	ubiquitin	ubiquitin	NN
cord-335871-zieuc7vk	62	4	assembly	assembly	NN
cord-335871-zieuc7vk	62	5	complex	complex	NN
cord-335871-zieuc7vk	62	6	(	(	-LRB-
cord-335871-zieuc7vk	62	7	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	62	8	)	)	-RRB-
cord-335871-zieuc7vk	62	9	is	be	VBZ
cord-335871-zieuc7vk	62	10	a	a	DT
cord-335871-zieuc7vk	62	11	multi	multi	JJ
cord-335871-zieuc7vk	62	12	-	-	JJ
cord-335871-zieuc7vk	62	13	protein	protein	JJ
cord-335871-zieuc7vk	62	14	E3	e3	NN
cord-335871-zieuc7vk	62	15	ubiquitin	ubiquitin	NN
cord-335871-zieuc7vk	62	16	ligase	ligase	NN
cord-335871-zieuc7vk	62	17	complex	complex	NN
cord-335871-zieuc7vk	62	18	composed	compose	VBN
cord-335871-zieuc7vk	62	19	of	of	IN
cord-335871-zieuc7vk	62	20	two	two	CD
cord-335871-zieuc7vk	62	21	stabilizing	stabilize	VBG
cord-335871-zieuc7vk	62	22	proteins	protein	NNS
cord-335871-zieuc7vk	62	23	,	,	,
cord-335871-zieuc7vk	62	24	the	the	DT
cord-335871-zieuc7vk	62	25	Heme	Heme	NNP
cord-335871-zieuc7vk	62	26	-	-	HYPH
cord-335871-zieuc7vk	62	27	Oxidized	oxidize	VBN
cord-335871-zieuc7vk	62	28	Iron	Iron	NNP
cord-335871-zieuc7vk	62	29	responsive	responsive	JJ
cord-335871-zieuc7vk	62	30	element	element	NN
cord-335871-zieuc7vk	62	31	binding	bind	VBG
cord-335871-zieuc7vk	62	32	protein	protein	NN
cord-335871-zieuc7vk	62	33	2	2	CD
cord-335871-zieuc7vk	62	34	ubiquitin	ubiquitin	NN
cord-335871-zieuc7vk	62	35	Ligase-1L	Ligase-1L	NNP
cord-335871-zieuc7vk	62	36	(	(	-LRB-
cord-335871-zieuc7vk	62	37	HOIL-1L	HOIL-1L	NNP
cord-335871-zieuc7vk	62	38	)	)	-RRB-
cord-335871-zieuc7vk	62	39	and	and	CC
cord-335871-zieuc7vk	62	40	Shank	Shank	NNP
cord-335871-zieuc7vk	62	41	-	-	HYPH
cord-335871-zieuc7vk	62	42	Associated	Associated	NNP
cord-335871-zieuc7vk	62	43	RH	RH	NNP
cord-335871-zieuc7vk	62	44	domain	domain	NN
cord-335871-zieuc7vk	62	45	-	-	:
cord-335871-zieuc7vk	62	46	Interacting	interact	VBG
cord-335871-zieuc7vk	62	47	Protein	protein	NN
cord-335871-zieuc7vk	62	48	(	(	-LRB-
cord-335871-zieuc7vk	62	49	SHARPIN	SHARPIN	NNP
cord-335871-zieuc7vk	62	50	)	)	-RRB-
cord-335871-zieuc7vk	62	51	,	,	,
cord-335871-zieuc7vk	62	52	and	and	CC
cord-335871-zieuc7vk	62	53	a	a	DT
cord-335871-zieuc7vk	62	54	catalytic	catalytic	JJ
cord-335871-zieuc7vk	62	55	component	component	NN
cord-335871-zieuc7vk	62	56	,	,	,
cord-335871-zieuc7vk	62	57	HOIL-1-Interacting	HOIL-1-Interacting	''
cord-335871-zieuc7vk	63	1	Protein	protein	NN
cord-335871-zieuc7vk	63	2	(	(	-LRB-
cord-335871-zieuc7vk	63	3	HOIP	HOIP	NNP
cord-335871-zieuc7vk	63	4	)	)	-RRB-
cord-335871-zieuc7vk	63	5	[	[	-LRB-
cord-335871-zieuc7vk	63	6	32	32	CD
cord-335871-zieuc7vk	63	7	]	]	-RRB-
cord-335871-zieuc7vk	63	8	[	[	-LRB-
cord-335871-zieuc7vk	63	9	33	33	CD
cord-335871-zieuc7vk	63	10	]	]	-RRB-
cord-335871-zieuc7vk	63	11	[	[	-LRB-
cord-335871-zieuc7vk	63	12	34	34	CD
cord-335871-zieuc7vk	63	13	]	]	-RRB-
cord-335871-zieuc7vk	63	14	(	(	-LRB-
cord-335871-zieuc7vk	63	15	Figure	figure	NN
cord-335871-zieuc7vk	63	16	3	3	CD
cord-335871-zieuc7vk	63	17	)	)	-RRB-
cord-335871-zieuc7vk	63	18	.	.	.
cord-335871-zieuc7vk	64	1	The	the	DT
cord-335871-zieuc7vk	64	2	proteins	protein	NNS
cord-335871-zieuc7vk	64	3	within	within	IN
cord-335871-zieuc7vk	64	4	the	the	DT
cord-335871-zieuc7vk	64	5	heteromeric	heteromeric	NN
cord-335871-zieuc7vk	64	6	complex	complex	NN
cord-335871-zieuc7vk	64	7	contain	contain	VBP
cord-335871-zieuc7vk	64	8	multiple	multiple	JJ
cord-335871-zieuc7vk	64	9	domains	domain	NNS
cord-335871-zieuc7vk	64	10	for	for	IN
cord-335871-zieuc7vk	64	11	interactions	interaction	NNS
cord-335871-zieuc7vk	64	12	within	within	IN
cord-335871-zieuc7vk	64	13	the	the	DT
cord-335871-zieuc7vk	64	14	complex	complex	JJ
cord-335871-zieuc7vk	64	15	,	,	,
cord-335871-zieuc7vk	64	16	ubiquitin	ubiquitin	JJ
cord-335871-zieuc7vk	64	17	binding	binding	NN
cord-335871-zieuc7vk	64	18	,	,	,
cord-335871-zieuc7vk	64	19	as	as	RB
cord-335871-zieuc7vk	64	20	well	well	RB
cord-335871-zieuc7vk	64	21	as	as	IN
cord-335871-zieuc7vk	64	22	catalytic	catalytic	JJ
cord-335871-zieuc7vk	64	23	activity	activity	NN
cord-335871-zieuc7vk	64	24	[	[	-LRB-
cord-335871-zieuc7vk	64	25	32	32	CD
cord-335871-zieuc7vk	64	26	]	]	-RRB-
cord-335871-zieuc7vk	65	1	[	[	-LRB-
cord-335871-zieuc7vk	65	2	33	33	CD
cord-335871-zieuc7vk	65	3	]	]	-RRB-
cord-335871-zieuc7vk	66	1	[	[	-LRB-
cord-335871-zieuc7vk	66	2	34	34	CD
cord-335871-zieuc7vk	66	3	]	]	-RRB-
cord-335871-zieuc7vk	66	4	[	[	-LRB-
cord-335871-zieuc7vk	66	5	35	35	CD
cord-335871-zieuc7vk	66	6	]	]	-RRB-
cord-335871-zieuc7vk	66	7	[	[	-LRB-
cord-335871-zieuc7vk	66	8	36	36	CD
cord-335871-zieuc7vk	66	9	]	]	-RRB-
cord-335871-zieuc7vk	66	10	.	.	.
cord-335871-zieuc7vk	67	1	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	67	2	is	be	VBZ
cord-335871-zieuc7vk	67	3	an	an	DT
cord-335871-zieuc7vk	67	4	essential	essential	JJ
cord-335871-zieuc7vk	67	5	regulator	regulator	NN
cord-335871-zieuc7vk	67	6	of	of	IN
cord-335871-zieuc7vk	67	7	NF	nf	NN
cord-335871-zieuc7vk	67	8	-	-	HYPH
cord-335871-zieuc7vk	67	9	κB	κb	CD
cord-335871-zieuc7vk	67	10	activation	activation	NN
cord-335871-zieuc7vk	67	11	and	and	CC
cord-335871-zieuc7vk	67	12	has	have	VBZ
cord-335871-zieuc7vk	67	13	been	be	VBN
cord-335871-zieuc7vk	67	14	shown	show	VBN
cord-335871-zieuc7vk	67	15	to	to	TO
cord-335871-zieuc7vk	67	16	act	act	VB
cord-335871-zieuc7vk	67	17	as	as	IN
cord-335871-zieuc7vk	67	18	a	a	DT
cord-335871-zieuc7vk	67	19	molecular	molecular	JJ
cord-335871-zieuc7vk	67	20	rheostat	rheostat	NN
cord-335871-zieuc7vk	67	21	,	,	,
cord-335871-zieuc7vk	67	22	regulating	regulate	VBG
cord-335871-zieuc7vk	67	23	the	the	DT
cord-335871-zieuc7vk	67	24	amplitude	amplitude	NN
cord-335871-zieuc7vk	67	25	of	of	IN
cord-335871-zieuc7vk	67	26	the	the	DT
cord-335871-zieuc7vk	67	27	epithelial	epithelial	NN
cord-335871-zieuc7vk	67	28	-	-	HYPH
cord-335871-zieuc7vk	67	29	driven	drive	VBN
cord-335871-zieuc7vk	67	30	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	67	31	response	response	NN
cord-335871-zieuc7vk	67	32	dung	dung	NN
cord-335871-zieuc7vk	67	33	IAV	iav	NN
cord-335871-zieuc7vk	67	34	infection	infection	NN
cord-335871-zieuc7vk	67	35	[	[	-LRB-
cord-335871-zieuc7vk	67	36	35	35	CD
cord-335871-zieuc7vk	67	37	,	,	,
cord-335871-zieuc7vk	67	38	36	36	CD
cord-335871-zieuc7vk	67	39	]	]	-RRB-
cord-335871-zieuc7vk	67	40	.	.	.
cord-335871-zieuc7vk	68	1	The	the	DT
cord-335871-zieuc7vk	68	2	respiratory	respiratory	JJ
cord-335871-zieuc7vk	68	3	epithelium	epithelium	NN
cord-335871-zieuc7vk	68	4	actively	actively	RB
cord-335871-zieuc7vk	68	5	participates	participate	VBZ
cord-335871-zieuc7vk	68	6	in	in	IN
cord-335871-zieuc7vk	68	7	the	the	DT
cord-335871-zieuc7vk	68	8	first	first	JJ
cord-335871-zieuc7vk	68	9	line	line	NN
cord-335871-zieuc7vk	68	10	of	of	IN
cord-335871-zieuc7vk	68	11	defense	defense	NN
cord-335871-zieuc7vk	68	12	against	against	IN
cord-335871-zieuc7vk	68	13	pathogens	pathogen	NNS
cord-335871-zieuc7vk	68	14	by	by	IN
cord-335871-zieuc7vk	68	15	orchestrating	orchestrate	VBG
cord-335871-zieuc7vk	68	16	host	host	NN
cord-335871-zieuc7vk	68	17	innate	innate	JJ
cord-335871-zieuc7vk	68	18	immunity	immunity	NN
cord-335871-zieuc7vk	68	19	[	[	-LRB-
cord-335871-zieuc7vk	68	20	23	23	CD
cord-335871-zieuc7vk	68	21	,	,	,
cord-335871-zieuc7vk	68	22	[	[	-LRB-
cord-335871-zieuc7vk	68	23	37	37	CD
cord-335871-zieuc7vk	68	24	]	]	-RRB-
cord-335871-zieuc7vk	68	25	[	[	-LRB-
cord-335871-zieuc7vk	68	26	38	38	CD
cord-335871-zieuc7vk	68	27	]	]	-RRB-
cord-335871-zieuc7vk	68	28	[	[	-LRB-
cord-335871-zieuc7vk	68	29	39	39	CD
cord-335871-zieuc7vk	68	30	]	]	-RRB-
cord-335871-zieuc7vk	68	31	.	.	.
cord-335871-zieuc7vk	69	1	As	as	IN
cord-335871-zieuc7vk	69	2	IAV	IAV	NNP
cord-335871-zieuc7vk	69	3	replicates	replicate	VBZ
cord-335871-zieuc7vk	69	4	within	within	IN
cord-335871-zieuc7vk	69	5	the	the	DT
cord-335871-zieuc7vk	69	6	respiratory	respiratory	JJ
cord-335871-zieuc7vk	69	7	epithelium	epithelium	NN
cord-335871-zieuc7vk	69	8	cells	cell	NNS
cord-335871-zieuc7vk	69	9	,	,	,
cord-335871-zieuc7vk	69	10	the	the	DT
cord-335871-zieuc7vk	69	11	cytosolic	cytosolic	JJ
cord-335871-zieuc7vk	69	12	pattern	pattern	NN
cord-335871-zieuc7vk	69	13	recognition	recognition	NN
cord-335871-zieuc7vk	69	14	receptor	receptor	NN
cord-335871-zieuc7vk	69	15	(	(	-LRB-
cord-335871-zieuc7vk	69	16	PRR	PRR	NNP
cord-335871-zieuc7vk	69	17	)	)	-RRB-
cord-335871-zieuc7vk	69	18	,	,	,
cord-335871-zieuc7vk	69	19	RIG	rig	NN
cord-335871-zieuc7vk	69	20	-	-	:
cord-335871-zieuc7vk	69	21	I	I	NNP
cord-335871-zieuc7vk	69	22	,	,	,
cord-335871-zieuc7vk	69	23	is	be	VBZ
cord-335871-zieuc7vk	69	24	activated	activate	VBN
cord-335871-zieuc7vk	69	25	and	and	CC
cord-335871-zieuc7vk	69	26	initiates	initiate	VBZ
cord-335871-zieuc7vk	69	27	formation	formation	NN
cord-335871-zieuc7vk	69	28	of	of	IN
cord-335871-zieuc7vk	69	29	a	a	DT
cord-335871-zieuc7vk	69	30	signaling	signal	VBG
cord-335871-zieuc7vk	69	31	platform	platform	NN
cord-335871-zieuc7vk	69	32	to	to	IN
cord-335871-zieuc7vk	69	33	which	which	WDT
cord-335871-zieuc7vk	69	34	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	69	35	is	be	VBZ
cord-335871-zieuc7vk	69	36	recruited	recruit	VBN
cord-335871-zieuc7vk	69	37	.	.	.
cord-335871-zieuc7vk	70	1	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	70	2	covalently	covalently	RB
cord-335871-zieuc7vk	70	3	attaches	attach	VBZ
cord-335871-zieuc7vk	70	4	Met-1	Met-1	NNP
cord-335871-zieuc7vk	70	5	linked	link	VBD
cord-335871-zieuc7vk	70	6	linear	linear	JJ
cord-335871-zieuc7vk	70	7	ubiquitin	ubiquitin	NN
cord-335871-zieuc7vk	70	8	chains	chain	NNS
cord-335871-zieuc7vk	70	9	to	to	IN
cord-335871-zieuc7vk	70	10	the	the	DT
cord-335871-zieuc7vk	70	11	NF	nf	NN
cord-335871-zieuc7vk	70	12	-	-	HYPH
cord-335871-zieuc7vk	70	13	κB	κb	CD
cord-335871-zieuc7vk	70	14	essential	essential	JJ
cord-335871-zieuc7vk	70	15	modulator	modulator	NN
cord-335871-zieuc7vk	70	16	(	(	-LRB-
cord-335871-zieuc7vk	70	17	NEMO	NEMO	NNP
cord-335871-zieuc7vk	70	18	)	)	-RRB-
cord-335871-zieuc7vk	70	19	,	,	,
cord-335871-zieuc7vk	70	20	a	a	DT
cord-335871-zieuc7vk	70	21	component	component	NN
cord-335871-zieuc7vk	70	22	of	of	IN
cord-335871-zieuc7vk	70	23	the	the	DT
cord-335871-zieuc7vk	70	24	inhibitor	inhibitor	NN
cord-335871-zieuc7vk	70	25	of	of	IN
cord-335871-zieuc7vk	70	26	NF	NF	NNP
cord-335871-zieuc7vk	71	1	-κB	-κb	ADD
cord-335871-zieuc7vk	71	2	(	(	-LRB-
cord-335871-zieuc7vk	71	3	IκB	iκb	NN
cord-335871-zieuc7vk	71	4	)	)	-RRB-
cord-335871-zieuc7vk	71	5	kinase	kinase	NN
cord-335871-zieuc7vk	71	6	(	(	-LRB-
cord-335871-zieuc7vk	71	7	IKK	IKK	NNP
cord-335871-zieuc7vk	71	8	)	)	-RRB-
cord-335871-zieuc7vk	71	9	complex	complex	VBP
cord-335871-zieuc7vk	71	10	along	along	IN
cord-335871-zieuc7vk	71	11	with	with	IN
cord-335871-zieuc7vk	71	12	IKKα	IKKα	NNS
cord-335871-zieuc7vk	71	13	and	and	CC
cord-335871-zieuc7vk	71	14	IKKβ	IKKβ	NNP
cord-335871-zieuc7vk	71	15	[	[	-LRB-
cord-335871-zieuc7vk	71	16	40	40	CD
cord-335871-zieuc7vk	71	17	,	,	,
cord-335871-zieuc7vk	71	18	41	41	CD
cord-335871-zieuc7vk	71	19	]	]	-RRB-
cord-335871-zieuc7vk	71	20	.	.	.
cord-335871-zieuc7vk	72	1	Due	due	IN
cord-335871-zieuc7vk	72	2	to	to	IN
cord-335871-zieuc7vk	72	3	the	the	DT
cord-335871-zieuc7vk	72	4	high	high	JJ
cord-335871-zieuc7vk	72	5	affinity	affinity	NN
cord-335871-zieuc7vk	72	6	of	of	IN
cord-335871-zieuc7vk	72	7	NEMO	NEMO	NNP
cord-335871-zieuc7vk	72	8	's	's	POS
cord-335871-zieuc7vk	72	9	ubiquitin	ubiquitin	NN
cord-335871-zieuc7vk	72	10	binding	bind	VBG
cord-335871-zieuc7vk	72	11	domain	domain	NN
cord-335871-zieuc7vk	72	12	for	for	IN
cord-335871-zieuc7vk	72	13	linear	linear	JJ
cord-335871-zieuc7vk	72	14	chains	chain	NNS
cord-335871-zieuc7vk	72	15	,	,	,
cord-335871-zieuc7vk	72	16	linear	linear	JJ
cord-335871-zieuc7vk	72	17	ubiquitination	ubiquitination	NN
cord-335871-zieuc7vk	72	18	of	of	IN
cord-335871-zieuc7vk	72	19	NEMO	NEMO	NNP
cord-335871-zieuc7vk	72	20	facilitates	facilitate	VBZ
cord-335871-zieuc7vk	72	21	the	the	DT
cord-335871-zieuc7vk	72	22	recruitment	recruitment	NN
cord-335871-zieuc7vk	72	23	of	of	IN
cord-335871-zieuc7vk	72	24	additional	additional	JJ
cord-335871-zieuc7vk	72	25	IKK	IKK	NNP
cord-335871-zieuc7vk	72	26	complexes	complex	NNS
cord-335871-zieuc7vk	72	27	,	,	,
cord-335871-zieuc7vk	72	28	which	which	WDT
cord-335871-zieuc7vk	72	29	results	result	VBZ
cord-335871-zieuc7vk	72	30	in	in	IN
cord-335871-zieuc7vk	72	31	the	the	DT
cord-335871-zieuc7vk	72	32	efficient	efficient	JJ
cord-335871-zieuc7vk	72	33	trans	trans	NN
cord-335871-zieuc7vk	72	34	-	-	NN
cord-335871-zieuc7vk	72	35	autophosphorylation	autophosphorylation	NN
cord-335871-zieuc7vk	72	36	and	and	CC
cord-335871-zieuc7vk	72	37	activation	activation	NN
cord-335871-zieuc7vk	72	38	of	of	IN
cord-335871-zieuc7vk	72	39	proximal	proximal	JJ
cord-335871-zieuc7vk	72	40	IKKβ	IKKβ	NNS
cord-335871-zieuc7vk	72	41	followed	follow	VBN
cord-335871-zieuc7vk	72	42	by	by	IN
cord-335871-zieuc7vk	72	43	the	the	DT
cord-335871-zieuc7vk	72	44	phosphorylation	phosphorylation	NN
cord-335871-zieuc7vk	72	45	and	and	CC
cord-335871-zieuc7vk	72	46	degradation	degradation	NN
cord-335871-zieuc7vk	72	47	of	of	IN
cord-335871-zieuc7vk	72	48	IκBα	IκBα	NNP
cord-335871-zieuc7vk	72	49	and	and	CC
cord-335871-zieuc7vk	72	50	robust	robust	JJ
cord-335871-zieuc7vk	72	51	NF	NF	NNP
cord-335871-zieuc7vk	72	52	-	-	HYPH
cord-335871-zieuc7vk	72	53	kB	kb	CD
cord-335871-zieuc7vk	72	54	activation	activation	NN
cord-335871-zieuc7vk	72	55	(	(	-LRB-
cord-335871-zieuc7vk	72	56	Figure	figure	NN
cord-335871-zieuc7vk	72	57	3	3	CD
cord-335871-zieuc7vk	72	58	)	)	-RRB-
cord-335871-zieuc7vk	72	59	[	[	-LRB-
cord-335871-zieuc7vk	72	60	34	34	CD
cord-335871-zieuc7vk	72	61	,	,	,
cord-335871-zieuc7vk	72	62	35	35	CD
cord-335871-zieuc7vk	72	63	,	,	,
cord-335871-zieuc7vk	72	64	40	40	CD
cord-335871-zieuc7vk	72	65	,	,	,
cord-335871-zieuc7vk	72	66	42	42	CD
cord-335871-zieuc7vk	72	67	,	,	,
cord-335871-zieuc7vk	72	68	43	43	CD
cord-335871-zieuc7vk	72	69	]	]	-RRB-
cord-335871-zieuc7vk	72	70	.	.	.
cord-335871-zieuc7vk	73	1	Recent	recent	JJ
cord-335871-zieuc7vk	73	2	reports	report	NNS
cord-335871-zieuc7vk	73	3	show	show	VBP
cord-335871-zieuc7vk	73	4	that	that	IN
cord-335871-zieuc7vk	73	5	destabilization	destabilization	NN
cord-335871-zieuc7vk	73	6	of	of	IN
cord-335871-zieuc7vk	73	7	respiratory	respiratory	JJ
cord-335871-zieuc7vk	73	8	epithelial	epithelial	JJ
cord-335871-zieuc7vk	73	9	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	73	10	,	,	,
cord-335871-zieuc7vk	73	11	via	via	IN
cord-335871-zieuc7vk	73	12	loss	loss	NN
cord-335871-zieuc7vk	73	13	of	of	IN
cord-335871-zieuc7vk	73	14	the	the	DT
cord-335871-zieuc7vk	73	15	non	non	JJ
cord-335871-zieuc7vk	73	16	-	-	JJ
cord-335871-zieuc7vk	73	17	catalytic	catalytic	JJ
cord-335871-zieuc7vk	73	18	component	component	NN
cord-335871-zieuc7vk	73	19	HOIL-1L	HOIL-1L	NNP
cord-335871-zieuc7vk	73	20	,	,	,
cord-335871-zieuc7vk	73	21	dampens	dampen	VBZ
cord-335871-zieuc7vk	73	22	the	the	DT
cord-335871-zieuc7vk	73	23	host	host	NN
cord-335871-zieuc7vk	73	24	response	response	NN
cord-335871-zieuc7vk	73	25	during	during	IN
cord-335871-zieuc7vk	73	26	severe	severe	JJ
cord-335871-zieuc7vk	73	27	influenza	influenza	NN
cord-335871-zieuc7vk	73	28	and	and	CC
cord-335871-zieuc7vk	73	29	promotes	promote	VBZ
cord-335871-zieuc7vk	73	30	survival	survival	NN
cord-335871-zieuc7vk	73	31	with	with	IN
cord-335871-zieuc7vk	73	32	reduced	reduce	VBN
cord-335871-zieuc7vk	73	33	lung	lung	NN
cord-335871-zieuc7vk	73	34	injury	injury	NN
cord-335871-zieuc7vk	73	35	as	as	RB
cord-335871-zieuc7vk	73	36	well	well	RB
cord-335871-zieuc7vk	73	37	as	as	IN
cord-335871-zieuc7vk	73	38	reduced	reduce	VBN
cord-335871-zieuc7vk	73	39	viral	viral	JJ
cord-335871-zieuc7vk	73	40	titers	titer	NNS
cord-335871-zieuc7vk	73	41	.	.	.
cord-335871-zieuc7vk	74	1	However	however	RB
cord-335871-zieuc7vk	74	2	,	,	,
cord-335871-zieuc7vk	74	3	when	when	WRB
cord-335871-zieuc7vk	74	4	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	74	5	activity	activity	NN
cord-335871-zieuc7vk	74	6	is	be	VBZ
cord-335871-zieuc7vk	74	7	abolished	abolish	VBN
cord-335871-zieuc7vk	74	8	through	through	IN
cord-335871-zieuc7vk	74	9	deletion	deletion	NN
cord-335871-zieuc7vk	74	10	of	of	IN
cord-335871-zieuc7vk	74	11	HOIP	HOIP	NNP
cord-335871-zieuc7vk	74	12	,	,	,
cord-335871-zieuc7vk	74	13	the	the	DT
cord-335871-zieuc7vk	74	14	alveolar	alveolar	JJ
cord-335871-zieuc7vk	74	15	epithelia	epithelium	NNS
cord-335871-zieuc7vk	74	16	driven	drive	VBD
cord-335871-zieuc7vk	74	17	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	74	18	response	response	NN
cord-335871-zieuc7vk	74	19	is	be	VBZ
cord-335871-zieuc7vk	74	20	inhibited	inhibit	VBN
cord-335871-zieuc7vk	74	21	and	and	CC
cord-335871-zieuc7vk	74	22	mortality	mortality	NN
cord-335871-zieuc7vk	74	23	is	be	VBZ
cord-335871-zieuc7vk	74	24	increased	increase	VBN
cord-335871-zieuc7vk	74	25	.	.	.
cord-335871-zieuc7vk	75	1	These	these	DT
cord-335871-zieuc7vk	75	2	findings	finding	NNS
cord-335871-zieuc7vk	75	3	highlight	highlight	VBP
cord-335871-zieuc7vk	75	4	the	the	DT
cord-335871-zieuc7vk	75	5	fine	fine	JJ
cord-335871-zieuc7vk	75	6	line	line	NN
cord-335871-zieuc7vk	75	7	between	between	IN
cord-335871-zieuc7vk	75	8	an	an	DT
cord-335871-zieuc7vk	75	9	excessive	excessive	JJ
cord-335871-zieuc7vk	75	10	and	and	CC
cord-335871-zieuc7vk	75	11	an	an	DT
cord-335871-zieuc7vk	75	12	inadequate	inadequate	JJ
cord-335871-zieuc7vk	75	13	immune	immune	JJ
cord-335871-zieuc7vk	75	14	response	response	NN
cord-335871-zieuc7vk	75	15	and	and	CC
cord-335871-zieuc7vk	75	16	suggest	suggest	VBP
cord-335871-zieuc7vk	75	17	that	that	IN
cord-335871-zieuc7vk	75	18	therapeutic	therapeutic	JJ
cord-335871-zieuc7vk	75	19	modulation	modulation	NN
cord-335871-zieuc7vk	75	20	of	of	IN
cord-335871-zieuc7vk	75	21	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	75	22	activity	activity	NN
cord-335871-zieuc7vk	75	23	may	may	MD
cord-335871-zieuc7vk	75	24	be	be	VB
cord-335871-zieuc7vk	75	25	crucial	crucial	JJ
cord-335871-zieuc7vk	75	26	,	,	,
cord-335871-zieuc7vk	75	27	as	as	IN
cord-335871-zieuc7vk	75	28	it	-PRON-	PRP
cord-335871-zieuc7vk	75	29	functions	function	VBZ
cord-335871-zieuc7vk	75	30	as	as	IN
cord-335871-zieuc7vk	75	31	a	a	DT
cord-335871-zieuc7vk	75	32	rheostat	rheostat	NN
cord-335871-zieuc7vk	75	33	regulating	regulate	VBG
cord-335871-zieuc7vk	75	34	the	the	DT
cord-335871-zieuc7vk	75	35	amplitude	amplitude	NN
cord-335871-zieuc7vk	75	36	of	of	IN
cord-335871-zieuc7vk	75	37	the	the	DT
cord-335871-zieuc7vk	75	38	host	host	NN
cord-335871-zieuc7vk	75	39	response	response	NN
cord-335871-zieuc7vk	75	40	to	to	IN
cord-335871-zieuc7vk	75	41	IAV	IAV	NNP
cord-335871-zieuc7vk	75	42	infection	infection	NN
cord-335871-zieuc7vk	75	43	.	.	.
cord-335871-zieuc7vk	76	1	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	76	2	covalently	covalently	RB
cord-335871-zieuc7vk	76	3	attaches	attach	VBZ
cord-335871-zieuc7vk	76	4	linear	linear	JJ
cord-335871-zieuc7vk	76	5	ubiquitin	ubiquitin	NN
cord-335871-zieuc7vk	76	6	chains	chain	NNS
cord-335871-zieuc7vk	76	7	to	to	IN
cord-335871-zieuc7vk	76	8	NEMO	NEMO	NNP
cord-335871-zieuc7vk	76	9	,	,	,
cord-335871-zieuc7vk	76	10	which	which	WDT
cord-335871-zieuc7vk	76	11	facilitates	facilitate	VBZ
cord-335871-zieuc7vk	76	12	the	the	DT
cord-335871-zieuc7vk	76	13	recruitment	recruitment	NN
cord-335871-zieuc7vk	76	14	of	of	IN
cord-335871-zieuc7vk	76	15	additional	additional	JJ
cord-335871-zieuc7vk	76	16	IKK	IKK	NNP
cord-335871-zieuc7vk	76	17	complexes	complex	NNS
cord-335871-zieuc7vk	76	18	.	.	.
cord-335871-zieuc7vk	77	1	Stably	stably	RB
cord-335871-zieuc7vk	77	2	docked	dock	VBN
cord-335871-zieuc7vk	77	3	IKK	IKK	NNP
cord-335871-zieuc7vk	77	4	complexes	complex	NNS
cord-335871-zieuc7vk	77	5	result	result	VBP
cord-335871-zieuc7vk	77	6	in	in	IN
cord-335871-zieuc7vk	77	7	the	the	DT
cord-335871-zieuc7vk	77	8	efficient	efficient	JJ
cord-335871-zieuc7vk	77	9	transautophosphorylation	transautophosphorylation	NN
cord-335871-zieuc7vk	77	10	and	and	CC
cord-335871-zieuc7vk	77	11	activation	activation	NN
cord-335871-zieuc7vk	77	12	of	of	IN
cord-335871-zieuc7vk	77	13	proximal	proximal	JJ
cord-335871-zieuc7vk	77	14	IKKα	IKKα	NNP
cord-335871-zieuc7vk	77	15	/	/	SYM
cord-335871-zieuc7vk	77	16	β	β	NN
cord-335871-zieuc7vk	77	17	,	,	,
cord-335871-zieuc7vk	77	18	followed	follow	VBN
cord-335871-zieuc7vk	77	19	by	by	IN
cord-335871-zieuc7vk	77	20	the	the	DT
cord-335871-zieuc7vk	77	21	phosphorylation	phosphorylation	NN
cord-335871-zieuc7vk	77	22	and	and	CC
cord-335871-zieuc7vk	77	23	degradation	degradation	NN
cord-335871-zieuc7vk	77	24	of	of	IN
cord-335871-zieuc7vk	77	25	IκBα	IκBα	NNP
cord-335871-zieuc7vk	77	26	.	.	.
cord-335871-zieuc7vk	78	1	NF	NF	NNP
cord-335871-zieuc7vk	78	2	-	-	HYPH
cord-335871-zieuc7vk	78	3	κB	κB	NNP
cord-335871-zieuc7vk	78	4	translocates	translocate	NNS
cord-335871-zieuc7vk	78	5	to	to	IN
cord-335871-zieuc7vk	78	6	the	the	DT
cord-335871-zieuc7vk	78	7	nucleus	nucleus	NN
cord-335871-zieuc7vk	78	8	to	to	TO
cord-335871-zieuc7vk	78	9	stimulate	stimulate	VB
cord-335871-zieuc7vk	78	10	transcription	transcription	NN
cord-335871-zieuc7vk	78	11	of	of	IN
cord-335871-zieuc7vk	78	12	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	78	13	genes	gene	NNS
cord-335871-zieuc7vk	78	14	.	.	.
cord-335871-zieuc7vk	79	1	Current	current	JJ
cord-335871-zieuc7vk	79	2	anti	anti	JJ
cord-335871-zieuc7vk	79	3	-	-	JJ
cord-335871-zieuc7vk	79	4	influenza	influenza	JJ
cord-335871-zieuc7vk	79	5	strategies	strategy	NNS
cord-335871-zieuc7vk	79	6	are	be	VBP
cord-335871-zieuc7vk	79	7	limited	limit	VBN
cord-335871-zieuc7vk	79	8	to	to	IN
cord-335871-zieuc7vk	79	9	yearly	yearly	JJ
cord-335871-zieuc7vk	79	10	vaccination	vaccination	NN
cord-335871-zieuc7vk	79	11	or	or	CC
cord-335871-zieuc7vk	79	12	administration	administration	NN
cord-335871-zieuc7vk	79	13	of	of	IN
cord-335871-zieuc7vk	79	14	antiviral	antiviral	JJ
cord-335871-zieuc7vk	79	15	drugs	drug	NNS
cord-335871-zieuc7vk	79	16	,	,	,
cord-335871-zieuc7vk	79	17	however	however	RB
cord-335871-zieuc7vk	79	18	,	,	,
cord-335871-zieuc7vk	79	19	short	short	JJ
cord-335871-zieuc7vk	79	20	therapeutic	therapeutic	JJ
cord-335871-zieuc7vk	79	21	windows	window	NNS
cord-335871-zieuc7vk	79	22	,	,	,
cord-335871-zieuc7vk	79	23	viral	viral	JJ
cord-335871-zieuc7vk	79	24	mutation	mutation	NN
cord-335871-zieuc7vk	79	25	,	,	,
cord-335871-zieuc7vk	79	26	and	and	CC
cord-335871-zieuc7vk	79	27	resistance	resistance	NN
cord-335871-zieuc7vk	79	28	to	to	IN
cord-335871-zieuc7vk	79	29	current	current	JJ
cord-335871-zieuc7vk	79	30	therapies	therapy	NNS
cord-335871-zieuc7vk	79	31	limit	limit	VBP
cord-335871-zieuc7vk	79	32	their	-PRON-	PRP$
cord-335871-zieuc7vk	79	33	effectiveness	effectiveness	NN
cord-335871-zieuc7vk	79	34	.	.	.
cord-335871-zieuc7vk	80	1	Despite	despite	IN
cord-335871-zieuc7vk	80	2	available	available	JJ
cord-335871-zieuc7vk	80	3	vaccination	vaccination	NN
cord-335871-zieuc7vk	80	4	and	and	CC
cord-335871-zieuc7vk	80	5	anti	anti	JJ
cord-335871-zieuc7vk	80	6	-	-	JJ
cord-335871-zieuc7vk	80	7	viral	viral	JJ
cord-335871-zieuc7vk	80	8	drugs	drug	NNS
cord-335871-zieuc7vk	80	9	,	,	,
cord-335871-zieuc7vk	80	10	the	the	DT
cord-335871-zieuc7vk	80	11	most	most	RBS
cord-335871-zieuc7vk	80	12	recent	recent	JJ
cord-335871-zieuc7vk	80	13	pandemic	pandemic	NN
cord-335871-zieuc7vk	80	14	in	in	IN
cord-335871-zieuc7vk	80	15	2009	2009	CD
cord-335871-zieuc7vk	80	16	resulted	result	VBD
cord-335871-zieuc7vk	80	17	in	in	IN
cord-335871-zieuc7vk	80	18	an	an	DT
cord-335871-zieuc7vk	80	19	estimated	estimate	VBN
cord-335871-zieuc7vk	80	20	151,700	151,700	CD
cord-335871-zieuc7vk	80	21	-575,400	-575,400	NN
cord-335871-zieuc7vk	80	22	deaths	death	NNS
cord-335871-zieuc7vk	80	23	in	in	IN
cord-335871-zieuc7vk	80	24	its	-PRON-	PRP$
cord-335871-zieuc7vk	80	25	first	first	JJ
cord-335871-zieuc7vk	80	26	year	year	NN
cord-335871-zieuc7vk	80	27	of	of	IN
cord-335871-zieuc7vk	80	28	circulation	circulation	NN
cord-335871-zieuc7vk	80	29	worldwide	worldwide	RB
cord-335871-zieuc7vk	80	30	[	[	-LRB-
cord-335871-zieuc7vk	80	31	44	44	CD
cord-335871-zieuc7vk	80	32	]	]	-RRB-
cord-335871-zieuc7vk	80	33	.	.	.
cord-335871-zieuc7vk	81	1	The	the	DT
cord-335871-zieuc7vk	81	2	pandemic	pandemic	NN
cord-335871-zieuc7vk	81	3	strain	strain	NN
cord-335871-zieuc7vk	81	4	contained	contain	VBD
cord-335871-zieuc7vk	81	5	a	a	DT
cord-335871-zieuc7vk	81	6	novel	novel	JJ
cord-335871-zieuc7vk	81	7	assortment	assortment	NN
cord-335871-zieuc7vk	81	8	of	of	IN
cord-335871-zieuc7vk	81	9	viral	viral	JJ
cord-335871-zieuc7vk	81	10	genes	gene	NNS
cord-335871-zieuc7vk	81	11	not	not	RB
cord-335871-zieuc7vk	81	12	previously	previously	RB
cord-335871-zieuc7vk	81	13	identified	identify	VBN
cord-335871-zieuc7vk	81	14	in	in	IN
cord-335871-zieuc7vk	81	15	animal	animal	NN
cord-335871-zieuc7vk	81	16	or	or	CC
cord-335871-zieuc7vk	81	17	human	human	JJ
cord-335871-zieuc7vk	81	18	populations	population	NNS
cord-335871-zieuc7vk	81	19	.	.	.
cord-335871-zieuc7vk	82	1	From	from	IN
cord-335871-zieuc7vk	82	2	its	-PRON-	PRP$
cord-335871-zieuc7vk	82	3	first	first	JJ
cord-335871-zieuc7vk	82	4	detection	detection	NN
cord-335871-zieuc7vk	82	5	in	in	IN
cord-335871-zieuc7vk	82	6	April	April	NNP
cord-335871-zieuc7vk	82	7	2009	2009	CD
cord-335871-zieuc7vk	82	8	,	,	,
cord-335871-zieuc7vk	82	9	it	-PRON-	PRP
cord-335871-zieuc7vk	82	10	was	be	VBD
cord-335871-zieuc7vk	82	11	only	only	RB
cord-335871-zieuc7vk	82	12	3	3	CD
cord-335871-zieuc7vk	82	13	months	month	NNS
cord-335871-zieuc7vk	82	14	until	until	IN
cord-335871-zieuc7vk	82	15	resistance	resistance	NN
cord-335871-zieuc7vk	82	16	to	to	IN
cord-335871-zieuc7vk	82	17	anti	anti	JJ
cord-335871-zieuc7vk	82	18	-	-	JJ
cord-335871-zieuc7vk	82	19	viral	viral	JJ
cord-335871-zieuc7vk	82	20	drugs	drug	NNS
cord-335871-zieuc7vk	82	21	was	be	VBD
cord-335871-zieuc7vk	82	22	reported	report	VBN
cord-335871-zieuc7vk	82	23	,	,	,
cord-335871-zieuc7vk	82	24	and	and	CC
cord-335871-zieuc7vk	82	25	it	-PRON-	PRP
cord-335871-zieuc7vk	82	26	took	take	VBD
cord-335871-zieuc7vk	82	27	an	an	DT
cord-335871-zieuc7vk	82	28	additional	additional	JJ
cord-335871-zieuc7vk	82	29	3	3	CD
cord-335871-zieuc7vk	82	30	months	month	NNS
cord-335871-zieuc7vk	82	31	before	before	IN
cord-335871-zieuc7vk	82	32	the	the	DT
cord-335871-zieuc7vk	82	33	first	first	JJ
cord-335871-zieuc7vk	82	34	vaccine	vaccine	NN
cord-335871-zieuc7vk	82	35	offering	offer	VBG
cord-335871-zieuc7vk	82	36	protection	protection	NN
cord-335871-zieuc7vk	82	37	from	from	IN
cord-335871-zieuc7vk	82	38	the	the	DT
cord-335871-zieuc7vk	82	39	pandemic	pandemic	NN
cord-335871-zieuc7vk	82	40	strain	strain	NN
cord-335871-zieuc7vk	82	41	was	be	VBD
cord-335871-zieuc7vk	82	42	administered	administer	VBN
cord-335871-zieuc7vk	82	43	[	[	-LRB-
cord-335871-zieuc7vk	82	44	45	45	CD
cord-335871-zieuc7vk	82	45	]	]	-RRB-
cord-335871-zieuc7vk	82	46	.	.	.
cord-335871-zieuc7vk	83	1	In	in	IN
cord-335871-zieuc7vk	83	2	addition	addition	NN
cord-335871-zieuc7vk	83	3	to	to	IN
cord-335871-zieuc7vk	83	4	emerging	emerge	VBG
cord-335871-zieuc7vk	83	5	pandemic	pandemic	NN
cord-335871-zieuc7vk	83	6	strains	strain	NNS
cord-335871-zieuc7vk	83	7	,	,	,
cord-335871-zieuc7vk	83	8	between	between	IN
cord-335871-zieuc7vk	83	9	291,000	291,000	CD
cord-335871-zieuc7vk	83	10	and	and	CC
cord-335871-zieuc7vk	83	11	646,000	646,000	CD
cord-335871-zieuc7vk	83	12	people	people	NNS
cord-335871-zieuc7vk	83	13	worldwide	worldwide	RB
cord-335871-zieuc7vk	83	14	die	die	VB
cord-335871-zieuc7vk	83	15	from	from	IN
cord-335871-zieuc7vk	83	16	seasonal	seasonal	JJ
cord-335871-zieuc7vk	83	17	influenza	influenza	NN
cord-335871-zieuc7vk	83	18	-	-	HYPH
cord-335871-zieuc7vk	83	19	related	relate	VBN
cord-335871-zieuc7vk	83	20	respiratory	respiratory	JJ
cord-335871-zieuc7vk	83	21	illnesses	illness	NNS
cord-335871-zieuc7vk	83	22	each	each	DT
cord-335871-zieuc7vk	83	23	year	year	NN
cord-335871-zieuc7vk	83	24	[	[	-LRB-
cord-335871-zieuc7vk	83	25	46	46	CD
cord-335871-zieuc7vk	83	26	]	]	-RRB-
cord-335871-zieuc7vk	83	27	.	.	.
cord-335871-zieuc7vk	84	1	Novel	novel	NN
cord-335871-zieuc7vk	84	2	mutations	mutation	NNS
cord-335871-zieuc7vk	84	3	and	and	CC
cord-335871-zieuc7vk	84	4	reassortments	reassortment	NNS
cord-335871-zieuc7vk	84	5	of	of	IN
cord-335871-zieuc7vk	84	6	the	the	DT
cord-335871-zieuc7vk	84	7	virus	virus	NN
cord-335871-zieuc7vk	84	8	will	will	MD
cord-335871-zieuc7vk	84	9	inevitably	inevitably	RB
cord-335871-zieuc7vk	84	10	lead	lead	VB
cord-335871-zieuc7vk	84	11	to	to	IN
cord-335871-zieuc7vk	84	12	the	the	DT
cord-335871-zieuc7vk	84	13	next	next	JJ
cord-335871-zieuc7vk	84	14	IAV	IAV	NNP
cord-335871-zieuc7vk	84	15	pandemic	pandemic	NN
cord-335871-zieuc7vk	84	16	;	;	:
cord-335871-zieuc7vk	84	17	therefore	therefore	RB
cord-335871-zieuc7vk	84	18	,	,	,
cord-335871-zieuc7vk	84	19	the	the	DT
cord-335871-zieuc7vk	84	20	use	use	NN
cord-335871-zieuc7vk	84	21	and	and	CC
cord-335871-zieuc7vk	84	22	development	development	NN
cord-335871-zieuc7vk	84	23	of	of	IN
cord-335871-zieuc7vk	84	24	therapeutics	therapeutic	NNS
cord-335871-zieuc7vk	84	25	that	that	WDT
cord-335871-zieuc7vk	84	26	target	target	VBP
cord-335871-zieuc7vk	84	27	conserved	conserve	VBN
cord-335871-zieuc7vk	84	28	host	host	NN
cord-335871-zieuc7vk	84	29	pathways	pathway	NNS
cord-335871-zieuc7vk	84	30	,	,	,
cord-335871-zieuc7vk	84	31	rather	rather	RB
cord-335871-zieuc7vk	84	32	than	than	IN
cord-335871-zieuc7vk	84	33	the	the	DT
cord-335871-zieuc7vk	84	34	virus	virus	NN
cord-335871-zieuc7vk	84	35	itself	-PRON-	PRP
cord-335871-zieuc7vk	84	36	,	,	,
cord-335871-zieuc7vk	84	37	hold	hold	VB
cord-335871-zieuc7vk	84	38	promise	promise	NN
cord-335871-zieuc7vk	84	39	to	to	TO
cord-335871-zieuc7vk	84	40	curtail	curtail	VB
cord-335871-zieuc7vk	84	41	the	the	DT
cord-335871-zieuc7vk	84	42	impact	impact	NN
cord-335871-zieuc7vk	84	43	of	of	IN
cord-335871-zieuc7vk	84	44	viral	viral	JJ
cord-335871-zieuc7vk	84	45	infection	infection	NN
cord-335871-zieuc7vk	84	46	.	.	.
cord-335871-zieuc7vk	85	1	Moreover	moreover	RB
cord-335871-zieuc7vk	85	2	,	,	,
cord-335871-zieuc7vk	85	3	a	a	DT
cord-335871-zieuc7vk	85	4	heterogeneous	heterogeneous	JJ
cord-335871-zieuc7vk	85	5	response	response	NN
cord-335871-zieuc7vk	85	6	to	to	IN
cord-335871-zieuc7vk	85	7	IAV	IAV	NNP
cord-335871-zieuc7vk	85	8	with	with	IN
cord-335871-zieuc7vk	85	9	the	the	DT
cord-335871-zieuc7vk	85	10	same	same	JJ
cord-335871-zieuc7vk	85	11	virulence	virulence	NN
cord-335871-zieuc7vk	85	12	exists	exist	VBZ
cord-335871-zieuc7vk	85	13	within	within	IN
cord-335871-zieuc7vk	85	14	the	the	DT
cord-335871-zieuc7vk	85	15	population	population	NN
cord-335871-zieuc7vk	85	16	,	,	,
cord-335871-zieuc7vk	85	17	suggesting	suggest	VBG
cord-335871-zieuc7vk	85	18	that	that	IN
cord-335871-zieuc7vk	85	19	host	host	NN
cord-335871-zieuc7vk	85	20	factors	factor	NNS
cord-335871-zieuc7vk	85	21	play	play	VBP
cord-335871-zieuc7vk	85	22	a	a	DT
cord-335871-zieuc7vk	85	23	crucial	crucial	JJ
cord-335871-zieuc7vk	85	24	role	role	NN
cord-335871-zieuc7vk	85	25	regulating	regulate	VBG
cord-335871-zieuc7vk	85	26	the	the	DT
cord-335871-zieuc7vk	85	27	host	host	NN
cord-335871-zieuc7vk	85	28	response	response	NN
cord-335871-zieuc7vk	85	29	and	and	CC
cord-335871-zieuc7vk	85	30	determining	determine	VBG
cord-335871-zieuc7vk	85	31	the	the	DT
cord-335871-zieuc7vk	85	32	severity	severity	NN
cord-335871-zieuc7vk	85	33	of	of	IN
cord-335871-zieuc7vk	85	34	lung	lung	NN
cord-335871-zieuc7vk	85	35	injury	injury	NN
cord-335871-zieuc7vk	85	36	[	[	-LRB-
cord-335871-zieuc7vk	85	37	2	2	CD
cord-335871-zieuc7vk	85	38	,	,	,
cord-335871-zieuc7vk	85	39	3	3	CD
cord-335871-zieuc7vk	85	40	,	,	,
cord-335871-zieuc7vk	85	41	47	47	CD
cord-335871-zieuc7vk	85	42	]	]	-RRB-
cord-335871-zieuc7vk	85	43	.	.	.
cord-335871-zieuc7vk	86	1	Additionally	additionally	RB
cord-335871-zieuc7vk	86	2	,	,	,
cord-335871-zieuc7vk	86	3	experimental	experimental	JJ
cord-335871-zieuc7vk	86	4	evidence	evidence	NN
cord-335871-zieuc7vk	86	5	from	from	IN
cord-335871-zieuc7vk	86	6	human	human	JJ
cord-335871-zieuc7vk	86	7	studies	study	NNS
cord-335871-zieuc7vk	86	8	and	and	CC
cord-335871-zieuc7vk	86	9	animal	animal	NN
cord-335871-zieuc7vk	86	10	models	model	NNS
cord-335871-zieuc7vk	86	11	of	of	IN
cord-335871-zieuc7vk	86	12	severe	severe	JJ
cord-335871-zieuc7vk	86	13	IAV	IAV	NNP
cord-335871-zieuc7vk	86	14	show	show	VBP
cord-335871-zieuc7vk	86	15	that	that	IN
cord-335871-zieuc7vk	86	16	viral	viral	JJ
cord-335871-zieuc7vk	86	17	titers	titer	NNS
cord-335871-zieuc7vk	86	18	do	do	VBP
cord-335871-zieuc7vk	86	19	not	not	RB
cord-335871-zieuc7vk	86	20	always	always	RB
cord-335871-zieuc7vk	86	21	correlate	correlate	VB
cord-335871-zieuc7vk	86	22	with	with	IN
cord-335871-zieuc7vk	86	23	severity	severity	NN
cord-335871-zieuc7vk	86	24	of	of	IN
cord-335871-zieuc7vk	86	25	disease	disease	NN
cord-335871-zieuc7vk	86	26	,	,	,
cord-335871-zieuc7vk	86	27	but	but	CC
cord-335871-zieuc7vk	86	28	rather	rather	RB
cord-335871-zieuc7vk	86	29	ARDS	ARDS	NNP
cord-335871-zieuc7vk	86	30	induced	induce	VBD
cord-335871-zieuc7vk	86	31	"	"	``
cord-335871-zieuc7vk	86	32	cytokine	cytokine	NN
cord-335871-zieuc7vk	86	33	storm	storm	NN
cord-335871-zieuc7vk	86	34	"	"	''
cord-335871-zieuc7vk	86	35	is	be	VBZ
cord-335871-zieuc7vk	86	36	the	the	DT
cord-335871-zieuc7vk	86	37	major	major	JJ
cord-335871-zieuc7vk	86	38	driver	driver	NN
cord-335871-zieuc7vk	86	39	of	of	IN
cord-335871-zieuc7vk	86	40	morbidity	morbidity	NN
cord-335871-zieuc7vk	86	41	and	and	CC
cord-335871-zieuc7vk	86	42	mortality	mortality	NN
cord-335871-zieuc7vk	86	43	[	[	-LRB-
cord-335871-zieuc7vk	86	44	4	4	CD
cord-335871-zieuc7vk	86	45	,	,	,
cord-335871-zieuc7vk	86	46	28	28	CD
cord-335871-zieuc7vk	86	47	,	,	,
cord-335871-zieuc7vk	86	48	38	38	CD
cord-335871-zieuc7vk	86	49	,	,	,
cord-335871-zieuc7vk	86	50	48	48	CD
cord-335871-zieuc7vk	86	51	]	]	-RRB-
cord-335871-zieuc7vk	86	52	.	.	.
cord-335871-zieuc7vk	87	1	Severe	severe	JJ
cord-335871-zieuc7vk	87	2	IAV	IAV	NNP
cord-335871-zieuc7vk	87	3	infection	infection	NN
cord-335871-zieuc7vk	87	4	is	be	VBZ
cord-335871-zieuc7vk	87	5	associated	associate	VBN
cord-335871-zieuc7vk	87	6	with	with	IN
cord-335871-zieuc7vk	87	7	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	87	8	cytokines	cytokine	NNS
cord-335871-zieuc7vk	87	9	in	in	IN
cord-335871-zieuc7vk	87	10	humans	human	NNS
cord-335871-zieuc7vk	87	11	and	and	CC
cord-335871-zieuc7vk	87	12	mice	mouse	NNS
cord-335871-zieuc7vk	87	13	.	.	.
cord-335871-zieuc7vk	88	1	Due	due	IN
cord-335871-zieuc7vk	88	2	to	to	IN
cord-335871-zieuc7vk	88	3	their	-PRON-	PRP$
cord-335871-zieuc7vk	88	4	pleiotropic	pleiotropic	JJ
cord-335871-zieuc7vk	88	5	and	and	CC
cord-335871-zieuc7vk	88	6	redundant	redundant	JJ
cord-335871-zieuc7vk	88	7	effects	effect	NNS
cord-335871-zieuc7vk	88	8	,	,	,
cord-335871-zieuc7vk	88	9	targeting	target	VBG
cord-335871-zieuc7vk	88	10	of	of	IN
cord-335871-zieuc7vk	88	11	individual	individual	JJ
cord-335871-zieuc7vk	88	12	cytokines	cytokine	NNS
cord-335871-zieuc7vk	88	13	may	may	MD
cord-335871-zieuc7vk	88	14	not	not	RB
cord-335871-zieuc7vk	88	15	be	be	VB
cord-335871-zieuc7vk	88	16	a	a	DT
cord-335871-zieuc7vk	88	17	suitable	suitable	JJ
cord-335871-zieuc7vk	88	18	approach	approach	NN
cord-335871-zieuc7vk	88	19	to	to	TO
cord-335871-zieuc7vk	88	20	reduce	reduce	VB
cord-335871-zieuc7vk	88	21	pathology	pathology	NN
cord-335871-zieuc7vk	88	22	during	during	IN
cord-335871-zieuc7vk	88	23	IAV	IAV	NNP
cord-335871-zieuc7vk	88	24	infection	infection	NN
cord-335871-zieuc7vk	88	25	.	.	.
cord-335871-zieuc7vk	89	1	Instead	instead	RB
cord-335871-zieuc7vk	89	2	,	,	,
cord-335871-zieuc7vk	89	3	dampening	dampen	VBG
cord-335871-zieuc7vk	89	4	of	of	IN
cord-335871-zieuc7vk	89	5	the	the	DT
cord-335871-zieuc7vk	89	6	immune	immune	JJ
cord-335871-zieuc7vk	89	7	response	response	NN
cord-335871-zieuc7vk	89	8	may	may	MD
cord-335871-zieuc7vk	89	9	be	be	VB
cord-335871-zieuc7vk	89	10	more	more	RBR
cord-335871-zieuc7vk	89	11	effective	effective	JJ
cord-335871-zieuc7vk	89	12	,	,	,
cord-335871-zieuc7vk	89	13	as	as	IN
cord-335871-zieuc7vk	89	14	was	be	VBD
cord-335871-zieuc7vk	89	15	the	the	DT
cord-335871-zieuc7vk	89	16	case	case	NN
cord-335871-zieuc7vk	89	17	with	with	IN
cord-335871-zieuc7vk	89	18	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	89	19	destabilization	destabilization	NN
cord-335871-zieuc7vk	89	20	noted	note	VBN
cord-335871-zieuc7vk	89	21	above	above	IN
cord-335871-zieuc7vk	89	22	[	[	-LRB-
cord-335871-zieuc7vk	89	23	36	36	CD
cord-335871-zieuc7vk	89	24	]	]	-RRB-
cord-335871-zieuc7vk	89	25	.	.	.
cord-335871-zieuc7vk	90	1	FDA	FDA	NNP
cord-335871-zieuc7vk	90	2	-	-	HYPH
cord-335871-zieuc7vk	90	3	approved	approve	VBN
cord-335871-zieuc7vk	90	4	anti	anti	JJ
cord-335871-zieuc7vk	90	5	-	-	JJ
cord-335871-zieuc7vk	90	6	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	90	7	drugs	drug	NNS
cord-335871-zieuc7vk	90	8	,	,	,
cord-335871-zieuc7vk	90	9	including	include	VBG
cord-335871-zieuc7vk	90	10	corticosteroids	corticosteroid	NNS
cord-335871-zieuc7vk	90	11	and	and	CC
cord-335871-zieuc7vk	90	12	statins	statin	NNS
cord-335871-zieuc7vk	90	13	,	,	,
cord-335871-zieuc7vk	90	14	have	have	VBP
cord-335871-zieuc7vk	90	15	been	be	VBN
cord-335871-zieuc7vk	90	16	proposed	propose	VBN
cord-335871-zieuc7vk	90	17	for	for	IN
cord-335871-zieuc7vk	90	18	the	the	DT
cord-335871-zieuc7vk	90	19	treatment	treatment	NN
cord-335871-zieuc7vk	90	20	of	of	IN
cord-335871-zieuc7vk	90	21	"	"	``
cord-335871-zieuc7vk	90	22	cytokine	cytokine	NN
cord-335871-zieuc7vk	90	23	storm	storm	NN
cord-335871-zieuc7vk	90	24	"	"	''
cord-335871-zieuc7vk	90	25	associated	associate	VBN
cord-335871-zieuc7vk	90	26	with	with	IN
cord-335871-zieuc7vk	90	27	severe	severe	JJ
cord-335871-zieuc7vk	90	28	IAV	IAV	NNP
cord-335871-zieuc7vk	90	29	infection	infection	NN
cord-335871-zieuc7vk	90	30	[	[	-LRB-
cord-335871-zieuc7vk	90	31	49	49	CD
cord-335871-zieuc7vk	90	32	]	]	-RRB-
cord-335871-zieuc7vk	90	33	.	.	.
cord-335871-zieuc7vk	91	1	Moreover	moreover	RB
cord-335871-zieuc7vk	91	2	,	,	,
cord-335871-zieuc7vk	91	3	current	current	JJ
cord-335871-zieuc7vk	91	4	data	datum	NNS
cord-335871-zieuc7vk	91	5	regarding	regard	VBG
cord-335871-zieuc7vk	91	6	their	-PRON-	PRP$
cord-335871-zieuc7vk	91	7	efficacy	efficacy	NN
cord-335871-zieuc7vk	91	8	is	be	VBZ
cord-335871-zieuc7vk	91	9	limited	limit	VBN
cord-335871-zieuc7vk	91	10	to	to	IN
cord-335871-zieuc7vk	91	11	mouse	mouse	NN
cord-335871-zieuc7vk	91	12	models	model	NNS
cord-335871-zieuc7vk	91	13	and	and	CC
cord-335871-zieuc7vk	91	14	retrospective	retrospective	JJ
cord-335871-zieuc7vk	91	15	patient	patient	NN
cord-335871-zieuc7vk	91	16	observations	observation	NNS
cord-335871-zieuc7vk	91	17	[	[	-LRB-
cord-335871-zieuc7vk	91	18	49	49	CD
cord-335871-zieuc7vk	91	19	,	,	,
cord-335871-zieuc7vk	91	20	50	50	CD
cord-335871-zieuc7vk	91	21	]	]	-RRB-
cord-335871-zieuc7vk	91	22	.	.	.
cord-335871-zieuc7vk	92	1	Corticosteroids	corticosteroid	NNS
cord-335871-zieuc7vk	92	2	have	have	VBP
cord-335871-zieuc7vk	92	3	been	be	VBN
cord-335871-zieuc7vk	92	4	shown	show	VBN
cord-335871-zieuc7vk	92	5	to	to	TO
cord-335871-zieuc7vk	92	6	be	be	VB
cord-335871-zieuc7vk	92	7	effective	effective	JJ
cord-335871-zieuc7vk	92	8	in	in	IN
cord-335871-zieuc7vk	92	9	limiting	limit	VBG
cord-335871-zieuc7vk	92	10	the	the	DT
cord-335871-zieuc7vk	92	11	inflammation	inflammation	NN
cord-335871-zieuc7vk	92	12	in	in	IN
cord-335871-zieuc7vk	92	13	in	in	IN
cord-335871-zieuc7vk	92	14	some	some	DT
cord-335871-zieuc7vk	92	15	lung	lung	NN
cord-335871-zieuc7vk	92	16	pathologies	pathology	NNS
cord-335871-zieuc7vk	92	17	[	[	-LRB-
cord-335871-zieuc7vk	92	18	49	49	CD
cord-335871-zieuc7vk	92	19	]	]	-RRB-
cord-335871-zieuc7vk	92	20	[	[	-LRB-
cord-335871-zieuc7vk	92	21	50	50	CD
cord-335871-zieuc7vk	92	22	]	]	-RRB-
cord-335871-zieuc7vk	92	23	[	[	-LRB-
cord-335871-zieuc7vk	92	24	51	51	CD
cord-335871-zieuc7vk	92	25	]	]	-RRB-
cord-335871-zieuc7vk	92	26	.	.	.
cord-335871-zieuc7vk	93	1	However	however	RB
cord-335871-zieuc7vk	93	2	,	,	,
cord-335871-zieuc7vk	93	3	observational	observational	JJ
cord-335871-zieuc7vk	93	4	studies	study	NNS
cord-335871-zieuc7vk	93	5	of	of	IN
cord-335871-zieuc7vk	93	6	the	the	DT
cord-335871-zieuc7vk	93	7	impact	impact	NN
cord-335871-zieuc7vk	93	8	of	of	IN
cord-335871-zieuc7vk	93	9	corticosteroid	corticosteroid	NN
cord-335871-zieuc7vk	93	10	treatment	treatment	NN
cord-335871-zieuc7vk	93	11	of	of	IN
cord-335871-zieuc7vk	93	12	IAV	IAV	NNP
cord-335871-zieuc7vk	93	13	-	-	HYPH
cord-335871-zieuc7vk	93	14	infected	infect	VBN
cord-335871-zieuc7vk	93	15	patients	patient	NNS
cord-335871-zieuc7vk	93	16	suggest	suggest	VBP
cord-335871-zieuc7vk	93	17	against	against	IN
cord-335871-zieuc7vk	93	18	their	-PRON-	PRP$
cord-335871-zieuc7vk	93	19	use	use	NN
cord-335871-zieuc7vk	93	20	;	;	:
cord-335871-zieuc7vk	93	21	with	with	IN
cord-335871-zieuc7vk	93	22	administration	administration	NN
cord-335871-zieuc7vk	93	23	associated	associate	VBN
cord-335871-zieuc7vk	93	24	with	with	IN
cord-335871-zieuc7vk	93	25	higher	high	JJR
cord-335871-zieuc7vk	93	26	incidence	incidence	NN
cord-335871-zieuc7vk	93	27	of	of	IN
cord-335871-zieuc7vk	93	28	hospital	hospital	NN
cord-335871-zieuc7vk	93	29	-	-	HYPH
cord-335871-zieuc7vk	93	30	acquired	acquire	VBN
cord-335871-zieuc7vk	93	31	pneumonia	pneumonia	NN
cord-335871-zieuc7vk	93	32	,	,	,
cord-335871-zieuc7vk	93	33	longer	long	JJR
cord-335871-zieuc7vk	93	34	duration	duration	NN
cord-335871-zieuc7vk	93	35	of	of	IN
cord-335871-zieuc7vk	93	36	mechanical	mechanical	JJ
cord-335871-zieuc7vk	93	37	ventilation	ventilation	NN
cord-335871-zieuc7vk	93	38	,	,	,
cord-335871-zieuc7vk	93	39	and	and	CC
cord-335871-zieuc7vk	93	40	increased	increase	VBN
cord-335871-zieuc7vk	93	41	mortality	mortality	NN
cord-335871-zieuc7vk	93	42	[	[	-LRB-
cord-335871-zieuc7vk	93	43	50	50	CD
cord-335871-zieuc7vk	93	44	]	]	-RRB-
cord-335871-zieuc7vk	93	45	.	.	.
cord-335871-zieuc7vk	94	1	Similarly	similarly	RB
cord-335871-zieuc7vk	94	2	,	,	,
cord-335871-zieuc7vk	94	3	clinical	clinical	JJ
cord-335871-zieuc7vk	94	4	evidence	evidence	NN
cord-335871-zieuc7vk	94	5	does	do	VBZ
cord-335871-zieuc7vk	94	6	not	not	RB
cord-335871-zieuc7vk	94	7	support	support	VB
cord-335871-zieuc7vk	94	8	corticosteroid	corticosteroid	NN
cord-335871-zieuc7vk	94	9	treatment	treatment	NN
cord-335871-zieuc7vk	94	10	for	for	IN
cord-335871-zieuc7vk	94	11	COVID-19	COVID-19	NNP
cord-335871-zieuc7vk	94	12	lung	lung	NN
cord-335871-zieuc7vk	94	13	injury	injury	NN
cord-335871-zieuc7vk	94	14	[	[	-LRB-
cord-335871-zieuc7vk	94	15	52	52	CD
cord-335871-zieuc7vk	94	16	]	]	-RRB-
cord-335871-zieuc7vk	94	17	.	.	.
cord-335871-zieuc7vk	95	1	Statins	statin	NNS
cord-335871-zieuc7vk	95	2	are	be	VBP
cord-335871-zieuc7vk	95	3	another	another	DT
cord-335871-zieuc7vk	95	4	class	class	NN
cord-335871-zieuc7vk	95	5	of	of	IN
cord-335871-zieuc7vk	95	6	drugs	drug	NNS
cord-335871-zieuc7vk	95	7	recognized	recognize	VBN
cord-335871-zieuc7vk	95	8	for	for	IN
cord-335871-zieuc7vk	95	9	their	-PRON-	PRP$
cord-335871-zieuc7vk	95	10	ability	ability	NN
cord-335871-zieuc7vk	95	11	to	to	TO
cord-335871-zieuc7vk	95	12	dampen	dampen	VB
cord-335871-zieuc7vk	95	13	inflammation	inflammation	NN
cord-335871-zieuc7vk	95	14	[	[	-LRB-
cord-335871-zieuc7vk	95	15	49	49	CD
cord-335871-zieuc7vk	95	16	]	]	-RRB-
cord-335871-zieuc7vk	95	17	.	.	.
cord-335871-zieuc7vk	96	1	While	while	IN
cord-335871-zieuc7vk	96	2	experimental	experimental	JJ
cord-335871-zieuc7vk	96	3	evidence	evidence	NN
cord-335871-zieuc7vk	96	4	from	from	IN
cord-335871-zieuc7vk	96	5	mouse	mouse	NN
cord-335871-zieuc7vk	96	6	models	model	NNS
cord-335871-zieuc7vk	96	7	using	use	VBG
cord-335871-zieuc7vk	96	8	statins	statin	NNS
cord-335871-zieuc7vk	96	9	during	during	IN
cord-335871-zieuc7vk	96	10	IAV	IAV	NNP
cord-335871-zieuc7vk	96	11	infection	infection	NN
cord-335871-zieuc7vk	96	12	have	have	VBP
cord-335871-zieuc7vk	96	13	been	be	VBN
cord-335871-zieuc7vk	96	14	inconclusive	inconclusive	JJ
cord-335871-zieuc7vk	96	15	regarding	regard	VBG
cord-335871-zieuc7vk	96	16	their	-PRON-	PRP$
cord-335871-zieuc7vk	96	17	benefit	benefit	NN
cord-335871-zieuc7vk	96	18	[	[	-LRB-
cord-335871-zieuc7vk	96	19	49	49	CD
cord-335871-zieuc7vk	96	20	,	,	,
cord-335871-zieuc7vk	96	21	53	53	CD
cord-335871-zieuc7vk	96	22	,	,	,
cord-335871-zieuc7vk	96	23	54	54	CD
cord-335871-zieuc7vk	96	24	]	]	-RRB-
cord-335871-zieuc7vk	96	25	,	,	,
cord-335871-zieuc7vk	96	26	retrospective	retrospective	JJ
cord-335871-zieuc7vk	96	27	analysis	analysis	NN
cord-335871-zieuc7vk	96	28	of	of	IN
cord-335871-zieuc7vk	96	29	patient	patient	NNP
cord-335871-zieuc7vk	96	30	data	datum	NNS
cord-335871-zieuc7vk	96	31	suggests	suggest	VBZ
cord-335871-zieuc7vk	96	32	an	an	DT
cord-335871-zieuc7vk	96	33	association	association	NN
cord-335871-zieuc7vk	96	34	between	between	IN
cord-335871-zieuc7vk	96	35	statin	statin	NN
cord-335871-zieuc7vk	96	36	treatment	treatment	NN
cord-335871-zieuc7vk	96	37	and	and	CC
cord-335871-zieuc7vk	96	38	lower	low	JJR
cord-335871-zieuc7vk	96	39	IAV	IAV	NNP
cord-335871-zieuc7vk	96	40	mortality	mortality	NN
cord-335871-zieuc7vk	96	41	rates	rate	NNS
cord-335871-zieuc7vk	96	42	[	[	-LRB-
cord-335871-zieuc7vk	96	43	55	55	CD
cord-335871-zieuc7vk	96	44	]	]	-RRB-
cord-335871-zieuc7vk	96	45	.	.	.
cord-335871-zieuc7vk	97	1	These	these	DT
cord-335871-zieuc7vk	97	2	examples	example	NNS
cord-335871-zieuc7vk	97	3	highlight	highlight	VBP
cord-335871-zieuc7vk	97	4	the	the	DT
cord-335871-zieuc7vk	97	5	need	need	NN
cord-335871-zieuc7vk	97	6	for	for	IN
cord-335871-zieuc7vk	97	7	new	new	JJ
cord-335871-zieuc7vk	97	8	avenues	avenue	NNS
cord-335871-zieuc7vk	97	9	of	of	IN
cord-335871-zieuc7vk	97	10	drug	drug	NN
cord-335871-zieuc7vk	97	11	discovery	discovery	NN
cord-335871-zieuc7vk	97	12	and	and	CC
cord-335871-zieuc7vk	97	13	validations	validation	NNS
cord-335871-zieuc7vk	97	14	,	,	,
cord-335871-zieuc7vk	97	15	as	as	IN
cord-335871-zieuc7vk	97	16	no	no	DT
cord-335871-zieuc7vk	97	17	currently	currently	RB
cord-335871-zieuc7vk	97	18	available	available	JJ
cord-335871-zieuc7vk	97	19	immune	immune	JJ
cord-335871-zieuc7vk	97	20	modulators	modulator	NNS
cord-335871-zieuc7vk	97	21	have	have	VBP
cord-335871-zieuc7vk	97	22	convincingly	convincingly	RB
cord-335871-zieuc7vk	97	23	demonstrated	demonstrate	VBN
cord-335871-zieuc7vk	97	24	their	-PRON-	PRP$
cord-335871-zieuc7vk	97	25	ability	ability	NN
cord-335871-zieuc7vk	97	26	to	to	TO
cord-335871-zieuc7vk	97	27	improve	improve	VB
cord-335871-zieuc7vk	97	28	outcomes	outcome	NNS
cord-335871-zieuc7vk	97	29	during	during	IN
cord-335871-zieuc7vk	97	30	influenza	influenza	NN
cord-335871-zieuc7vk	97	31	infection	infection	NN
cord-335871-zieuc7vk	97	32	.	.	.
cord-335871-zieuc7vk	98	1	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	98	2	represents	represent	VBZ
cord-335871-zieuc7vk	98	3	a	a	DT
cord-335871-zieuc7vk	98	4	potential	potential	JJ
cord-335871-zieuc7vk	98	5	new	new	JJ
cord-335871-zieuc7vk	98	6	target	target	NN
cord-335871-zieuc7vk	98	7	for	for	IN
cord-335871-zieuc7vk	98	8	limiting	limit	VBG
cord-335871-zieuc7vk	98	9	the	the	DT
cord-335871-zieuc7vk	98	10	pathological	pathological	JJ
cord-335871-zieuc7vk	98	11	inflammation	inflammation	NN
cord-335871-zieuc7vk	98	12	that	that	WDT
cord-335871-zieuc7vk	98	13	occurs	occur	VBZ
cord-335871-zieuc7vk	98	14	during	during	IN
cord-335871-zieuc7vk	98	15	IAV	IAV	NNP
cord-335871-zieuc7vk	98	16	infection	infection	NN
cord-335871-zieuc7vk	98	17	.	.	.
cord-335871-zieuc7vk	99	1	Several	several	JJ
cord-335871-zieuc7vk	99	2	chemical	chemical	NN
cord-335871-zieuc7vk	99	3	inhibitors	inhibitor	NNS
cord-335871-zieuc7vk	99	4	as	as	RB
cord-335871-zieuc7vk	99	5	well	well	RB
cord-335871-zieuc7vk	99	6	as	as	IN
cord-335871-zieuc7vk	99	7	peptides	peptide	NNS
cord-335871-zieuc7vk	99	8	that	that	WDT
cord-335871-zieuc7vk	99	9	bind	bind	VBP
cord-335871-zieuc7vk	99	10	HOIP	HOIP	NNP
cord-335871-zieuc7vk	99	11	have	have	VBP
cord-335871-zieuc7vk	99	12	been	be	VBN
cord-335871-zieuc7vk	99	13	used	use	VBN
cord-335871-zieuc7vk	99	14	to	to	TO
cord-335871-zieuc7vk	99	15	inhibit	inhibit	VB
cord-335871-zieuc7vk	99	16	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	99	17	activity	activity	NN
cord-335871-zieuc7vk	99	18	in	in	IN
cord-335871-zieuc7vk	99	19	cell	cell	NN
cord-335871-zieuc7vk	99	20	culture	culture	NN
cord-335871-zieuc7vk	99	21	[	[	-LRB-
cord-335871-zieuc7vk	99	22	56	56	CD
cord-335871-zieuc7vk	99	23	]	]	-RRB-
cord-335871-zieuc7vk	100	1	[	[	-LRB-
cord-335871-zieuc7vk	100	2	57	57	CD
cord-335871-zieuc7vk	100	3	]	]	-RRB-
cord-335871-zieuc7vk	100	4	[	[	-LRB-
cord-335871-zieuc7vk	100	5	58	58	CD
cord-335871-zieuc7vk	100	6	]	]	-RRB-
cord-335871-zieuc7vk	101	1	[	[	-LRB-
cord-335871-zieuc7vk	101	2	59	59	CD
cord-335871-zieuc7vk	101	3	]	]	-RRB-
cord-335871-zieuc7vk	101	4	and	and	CC
cord-335871-zieuc7vk	101	5	in	in	IN
cord-335871-zieuc7vk	101	6	vitro	vitro	FW
cord-335871-zieuc7vk	101	7	assays	assay	NNS
cord-335871-zieuc7vk	101	8	[	[	-LRB-
cord-335871-zieuc7vk	102	1	60	60	CD
cord-335871-zieuc7vk	102	2	,	,	,
cord-335871-zieuc7vk	102	3	61	61	CD
cord-335871-zieuc7vk	102	4	]	]	-RRB-
cord-335871-zieuc7vk	102	5	and	and	CC
cord-335871-zieuc7vk	102	6	support	support	VBP
cord-335871-zieuc7vk	102	7	the	the	DT
cord-335871-zieuc7vk	102	8	specific	specific	JJ
cord-335871-zieuc7vk	102	9	targetablility	targetablility	NN
cord-335871-zieuc7vk	102	10	of	of	IN
cord-335871-zieuc7vk	102	11	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	102	12	(	(	-LRB-
cord-335871-zieuc7vk	102	13	Figure	Figure	NNP
cord-335871-zieuc7vk	102	14	4	4	CD
cord-335871-zieuc7vk	102	15	)	)	-RRB-
cord-335871-zieuc7vk	102	16	.	.	.
cord-335871-zieuc7vk	103	1	Currently	currently	RB
cord-335871-zieuc7vk	103	2	,	,	,
cord-335871-zieuc7vk	103	3	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	103	4	inhibitors	inhibitor	NNS
cord-335871-zieuc7vk	103	5	fall	fall	VBP
cord-335871-zieuc7vk	103	6	into	into	IN
cord-335871-zieuc7vk	103	7	two	two	CD
cord-335871-zieuc7vk	103	8	categories	category	NNS
cord-335871-zieuc7vk	103	9	:	:	:
cord-335871-zieuc7vk	103	10	those	those	DT
cord-335871-zieuc7vk	103	11	that	that	WDT
cord-335871-zieuc7vk	103	12	target	target	VBP
cord-335871-zieuc7vk	103	13	the	the	DT
cord-335871-zieuc7vk	103	14	catalytic	catalytic	JJ
cord-335871-zieuc7vk	103	15	activity	activity	NN
cord-335871-zieuc7vk	103	16	of	of	IN
cord-335871-zieuc7vk	103	17	HOIP	HOIP	NNP
cord-335871-zieuc7vk	103	18	(	(	-LRB-
cord-335871-zieuc7vk	103	19	ie	ie	FW
cord-335871-zieuc7vk	103	20	.	.	.
cord-335871-zieuc7vk	104	1	BAY117082	BAY117082	NNP
cord-335871-zieuc7vk	104	2	,	,	,
cord-335871-zieuc7vk	104	3	Gliotoxin	Gliotoxin	NNP
cord-335871-zieuc7vk	104	4	,	,	,
cord-335871-zieuc7vk	104	5	HOIPIN	HOIPIN	NNP
cord-335871-zieuc7vk	104	6	)	)	-RRB-
cord-335871-zieuc7vk	104	7	or	or	CC
cord-335871-zieuc7vk	104	8	those	those	DT
cord-335871-zieuc7vk	104	9	that	that	WDT
cord-335871-zieuc7vk	104	10	disrupt	disrupt	VBP
cord-335871-zieuc7vk	104	11	the	the	DT
cord-335871-zieuc7vk	104	12	interaction	interaction	NN
cord-335871-zieuc7vk	104	13	between	between	IN
cord-335871-zieuc7vk	104	14	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	104	15	components	component	NNS
cord-335871-zieuc7vk	104	16	to	to	TO
cord-335871-zieuc7vk	104	17	destabilize	destabilize	VB
cord-335871-zieuc7vk	104	18	the	the	DT
cord-335871-zieuc7vk	104	19	complex	complex	NN
cord-335871-zieuc7vk	104	20	(	(	-LRB-
cord-335871-zieuc7vk	104	21	ie	ie	FW
cord-335871-zieuc7vk	104	22	.	.	.
cord-335871-zieuc7vk	104	23	stapled	staple	VBN
cord-335871-zieuc7vk	104	24	peptides	peptide	NNS
cord-335871-zieuc7vk	104	25	)	)	-RRB-
cord-335871-zieuc7vk	104	26	.	.	.
cord-335871-zieuc7vk	105	1	BAY117082	BAY117082	NNP
cord-335871-zieuc7vk	105	2	,	,	,
cord-335871-zieuc7vk	105	3	a	a	DT
cord-335871-zieuc7vk	105	4	small	small	JJ
cord-335871-zieuc7vk	105	5	molecule	molecule	NN
cord-335871-zieuc7vk	105	6	commonly	commonly	RB
cord-335871-zieuc7vk	105	7	used	use	VBN
cord-335871-zieuc7vk	105	8	as	as	IN
cord-335871-zieuc7vk	105	9	an	an	DT
cord-335871-zieuc7vk	105	10	inhibitor	inhibitor	NN
cord-335871-zieuc7vk	105	11	of	of	IN
cord-335871-zieuc7vk	105	12	NF	nf	NN
cord-335871-zieuc7vk	105	13	-	-	HYPH
cord-335871-zieuc7vk	105	14	κB	κb	CD
cord-335871-zieuc7vk	105	15	activation	activation	NN
cord-335871-zieuc7vk	105	16	.	.	.
cord-335871-zieuc7vk	106	1	It	-PRON-	PRP
cord-335871-zieuc7vk	106	2	has	have	VBZ
cord-335871-zieuc7vk	106	3	been	be	VBN
cord-335871-zieuc7vk	106	4	observed	observe	VBN
cord-335871-zieuc7vk	106	5	that	that	DT
cord-335871-zieuc7vk	106	6	treatment	treatment	NN
cord-335871-zieuc7vk	106	7	of	of	IN
cord-335871-zieuc7vk	106	8	RAW	raw	JJ
cord-335871-zieuc7vk	106	9	264.7	264.7	CD
cord-335871-zieuc7vk	106	10	macrophages	macrophage	NNS
cord-335871-zieuc7vk	106	11	with	with	IN
cord-335871-zieuc7vk	106	12	BAY117082	bay117082	RB
cord-335871-zieuc7vk	106	13	prevented	prevent	VBN
cord-335871-zieuc7vk	106	14	IL-1	IL-1	NNP
cord-335871-zieuc7vk	106	15	stimulated	stimulate	VBD
cord-335871-zieuc7vk	106	16	formation	formation	NN
cord-335871-zieuc7vk	106	17	of	of	IN
cord-335871-zieuc7vk	106	18	linear	linear	JJ
cord-335871-zieuc7vk	106	19	ubiquitin	ubiquitin	NN
cord-335871-zieuc7vk	106	20	chains	chain	NNS
cord-335871-zieuc7vk	106	21	.	.	.
cord-335871-zieuc7vk	107	1	Further	further	JJ
cord-335871-zieuc7vk	107	2	investigation	investigation	NN
cord-335871-zieuc7vk	107	3	revealed	reveal	VBD
cord-335871-zieuc7vk	107	4	that	that	IN
cord-335871-zieuc7vk	107	5	BAY117082	bay117082	PRP
cord-335871-zieuc7vk	107	6	irreversibly	irreversibly	RB
cord-335871-zieuc7vk	107	7	inhibits	inhibit	VBZ
cord-335871-zieuc7vk	107	8	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	107	9	through	through	IN
cord-335871-zieuc7vk	107	10	a	a	DT
cord-335871-zieuc7vk	107	11	chemical	chemical	JJ
cord-335871-zieuc7vk	107	12	reaction	reaction	NN
cord-335871-zieuc7vk	107	13	with	with	IN
cord-335871-zieuc7vk	107	14	cysteine	cysteine	NN
cord-335871-zieuc7vk	107	15	residues	residue	NNS
cord-335871-zieuc7vk	107	16	in	in	IN
cord-335871-zieuc7vk	107	17	the	the	DT
cord-335871-zieuc7vk	107	18	active	active	JJ
cord-335871-zieuc7vk	107	19	site	site	NN
cord-335871-zieuc7vk	107	20	of	of	IN
cord-335871-zieuc7vk	107	21	HOIP	HOIP	NNP
cord-335871-zieuc7vk	107	22	,	,	,
cord-335871-zieuc7vk	107	23	the	the	DT
cord-335871-zieuc7vk	107	24	catalytic	catalytic	JJ
cord-335871-zieuc7vk	107	25	unit	unit	NN
cord-335871-zieuc7vk	107	26	of	of	IN
cord-335871-zieuc7vk	107	27	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	107	28	[	[	-LRB-
cord-335871-zieuc7vk	107	29	58	58	CD
cord-335871-zieuc7vk	107	30	]	]	-RRB-
cord-335871-zieuc7vk	107	31	.	.	.
cord-335871-zieuc7vk	108	1	While	while	IN
cord-335871-zieuc7vk	108	2	BAY117082	BAY117082	NNP
cord-335871-zieuc7vk	108	3	represents	represent	VBZ
cord-335871-zieuc7vk	108	4	a	a	DT
cord-335871-zieuc7vk	108	5	potent	potent	JJ
cord-335871-zieuc7vk	108	6	inhibitor	inhibitor	NN
cord-335871-zieuc7vk	108	7	of	of	IN
cord-335871-zieuc7vk	108	8	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	108	9	activity	activity	NN
cord-335871-zieuc7vk	108	10	,	,	,
cord-335871-zieuc7vk	108	11	it	-PRON-	PRP
cord-335871-zieuc7vk	108	12	targets	target	VBZ
cord-335871-zieuc7vk	108	13	multiple	multiple	JJ
cord-335871-zieuc7vk	108	14	components	component	NNS
cord-335871-zieuc7vk	108	15	of	of	IN
cord-335871-zieuc7vk	108	16	the	the	DT
cord-335871-zieuc7vk	108	17	ubiquitin	ubiquitin	NN
cord-335871-zieuc7vk	108	18	system	system	NN
cord-335871-zieuc7vk	108	19	,	,	,
cord-335871-zieuc7vk	108	20	including	include	VBG
cord-335871-zieuc7vk	108	21	inhibition	inhibition	NN
cord-335871-zieuc7vk	108	22	of	of	IN
cord-335871-zieuc7vk	108	23	E2	E2	NNP
cord-335871-zieuc7vk	108	24	ubiquitin	ubiquitin	NN
cord-335871-zieuc7vk	108	25	conjugating	conjugate	VBG
cord-335871-zieuc7vk	108	26	enzymes	enzyme	NNS
cord-335871-zieuc7vk	108	27	,	,	,
cord-335871-zieuc7vk	108	28	and	and	CC
cord-335871-zieuc7vk	108	29	possible	possible	JJ
cord-335871-zieuc7vk	108	30	proteasome	proteasome	VBN
cord-335871-zieuc7vk	108	31	inhibition	inhibition	NN
cord-335871-zieuc7vk	108	32	[	[	-LRB-
cord-335871-zieuc7vk	108	33	58	58	CD
cord-335871-zieuc7vk	108	34	]	]	-RRB-
cord-335871-zieuc7vk	108	35	.	.	.
cord-335871-zieuc7vk	109	1	As	as	IN
cord-335871-zieuc7vk	109	2	such	such	JJ
cord-335871-zieuc7vk	109	3	,	,	,
cord-335871-zieuc7vk	109	4	use	use	NN
cord-335871-zieuc7vk	109	5	of	of	IN
cord-335871-zieuc7vk	109	6	BAY117082	bay117082	NN
cord-335871-zieuc7vk	109	7	is	be	VBZ
cord-335871-zieuc7vk	109	8	not	not	RB
cord-335871-zieuc7vk	109	9	suitable	suitable	JJ
cord-335871-zieuc7vk	109	10	for	for	IN
cord-335871-zieuc7vk	109	11	the	the	DT
cord-335871-zieuc7vk	109	12	study	study	NN
cord-335871-zieuc7vk	109	13	of	of	IN
cord-335871-zieuc7vk	109	14	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	109	15	-	-	HYPH
cord-335871-zieuc7vk	109	16	dependent	dependent	JJ
cord-335871-zieuc7vk	109	17	physiological	physiological	JJ
cord-335871-zieuc7vk	109	18	functions	function	NNS
cord-335871-zieuc7vk	109	19	or	or	CC
cord-335871-zieuc7vk	109	20	therapeutic	therapeutic	JJ
cord-335871-zieuc7vk	109	21	targeting	targeting	NN
cord-335871-zieuc7vk	109	22	of	of	IN
cord-335871-zieuc7vk	109	23	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	109	24	activity	activity	NN
cord-335871-zieuc7vk	109	25	in	in	IN
cord-335871-zieuc7vk	109	26	disease	disease	NN
cord-335871-zieuc7vk	109	27	.	.	.
cord-335871-zieuc7vk	110	1	Gliotoxin	Gliotoxin	NNP
cord-335871-zieuc7vk	110	2	,	,	,
cord-335871-zieuc7vk	110	3	a	a	DT
cord-335871-zieuc7vk	110	4	fungal	fungal	NN
cord-335871-zieuc7vk	110	5	metabolite	metabolite	NN
cord-335871-zieuc7vk	110	6	,	,	,
cord-335871-zieuc7vk	110	7	was	be	VBD
cord-335871-zieuc7vk	110	8	identified	identify	VBN
cord-335871-zieuc7vk	110	9	in	in	IN
cord-335871-zieuc7vk	110	10	a	a	DT
cord-335871-zieuc7vk	110	11	highthroughput	highthroughput	NN
cord-335871-zieuc7vk	110	12	screening	screening	NN
cord-335871-zieuc7vk	110	13	for	for	IN
cord-335871-zieuc7vk	110	14	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	110	15	inhibitors	inhibitor	NNS
cord-335871-zieuc7vk	110	16	using	use	VBG
cord-335871-zieuc7vk	110	17	a	a	DT
cord-335871-zieuc7vk	110	18	time	time	NN
cord-335871-zieuc7vk	110	19	-	-	HYPH
cord-335871-zieuc7vk	110	20	resolved	resolve	VBN
cord-335871-zieuc7vk	110	21	FRET	fret	NN
cord-335871-zieuc7vk	110	22	-	-	HYPH
cord-335871-zieuc7vk	110	23	based	base	VBN
cord-335871-zieuc7vk	110	24	screening	screening	NN
cord-335871-zieuc7vk	110	25	system	system	NN
cord-335871-zieuc7vk	110	26	.	.	.
cord-335871-zieuc7vk	111	1	While	while	IN
cord-335871-zieuc7vk	111	2	gliotoxin	gliotoxin	NNP
cord-335871-zieuc7vk	111	3	is	be	VBZ
cord-335871-zieuc7vk	111	4	known	know	VBN
cord-335871-zieuc7vk	111	5	to	to	TO
cord-335871-zieuc7vk	111	6	have	have	VB
cord-335871-zieuc7vk	111	7	multiple	multiple	JJ
cord-335871-zieuc7vk	111	8	cellular	cellular	JJ
cord-335871-zieuc7vk	111	9	targets	target	NNS
cord-335871-zieuc7vk	111	10	,	,	,
cord-335871-zieuc7vk	111	11	it	-PRON-	PRP
cord-335871-zieuc7vk	111	12	is	be	VBZ
cord-335871-zieuc7vk	111	13	able	able	JJ
cord-335871-zieuc7vk	111	14	to	to	TO
cord-335871-zieuc7vk	111	15	inhibit	inhibit	VB
cord-335871-zieuc7vk	111	16	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	111	17	activity	activity	NN
cord-335871-zieuc7vk	111	18	and	and	CC
cord-335871-zieuc7vk	111	19	downstream	downstream	JJ
cord-335871-zieuc7vk	111	20	activation	activation	NN
cord-335871-zieuc7vk	111	21	of	of	IN
cord-335871-zieuc7vk	111	22	NF	nf	NN
cord-335871-zieuc7vk	111	23	-	-	HYPH
cord-335871-zieuc7vk	111	24	κB	κB	NNP
cord-335871-zieuc7vk	111	25	at	at	IN
cord-335871-zieuc7vk	111	26	10x	10x	CC
cord-335871-zieuc7vk	111	27	lower	low	JJR
cord-335871-zieuc7vk	111	28	concentrations	concentration	NNS
cord-335871-zieuc7vk	111	29	[	[	-LRB-
cord-335871-zieuc7vk	111	30	61	61	CD
cord-335871-zieuc7vk	111	31	]	]	-RRB-
cord-335871-zieuc7vk	111	32	.	.	.
cord-335871-zieuc7vk	112	1	Gliotoxin	Gliotoxin	NNP
cord-335871-zieuc7vk	112	2	's	's	POS
cord-335871-zieuc7vk	112	3	strong	strong	JJ
cord-335871-zieuc7vk	112	4	,	,	,
cord-335871-zieuc7vk	112	5	irreversible	irreversible	JJ
cord-335871-zieuc7vk	112	6	binding	binding	NN
cord-335871-zieuc7vk	112	7	to	to	IN
cord-335871-zieuc7vk	112	8	the	the	DT
cord-335871-zieuc7vk	112	9	catalytic	catalytic	JJ
cord-335871-zieuc7vk	112	10	site	site	NN
cord-335871-zieuc7vk	112	11	of	of	IN
cord-335871-zieuc7vk	112	12	HOIP	HOIP	NNP
cord-335871-zieuc7vk	112	13	makes	make	VBZ
cord-335871-zieuc7vk	112	14	it	-PRON-	PRP
cord-335871-zieuc7vk	112	15	a	a	DT
cord-335871-zieuc7vk	112	16	selective	selective	JJ
cord-335871-zieuc7vk	112	17	inhibitor	inhibitor	NN
cord-335871-zieuc7vk	112	18	of	of	IN
cord-335871-zieuc7vk	112	19	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	112	20	activity	activity	NN
cord-335871-zieuc7vk	112	21	[	[	-LRB-
cord-335871-zieuc7vk	112	22	61	61	CD
cord-335871-zieuc7vk	112	23	]	]	-RRB-
cord-335871-zieuc7vk	112	24	.	.	.
cord-335871-zieuc7vk	113	1	Interestingly	interestingly	RB
cord-335871-zieuc7vk	113	2	,	,	,
cord-335871-zieuc7vk	113	3	the	the	DT
cord-335871-zieuc7vk	113	4	potency	potency	NN
cord-335871-zieuc7vk	113	5	of	of	IN
cord-335871-zieuc7vk	113	6	gliotoxin	gliotoxin	NNP
cord-335871-zieuc7vk	113	7	has	have	VBZ
cord-335871-zieuc7vk	113	8	been	be	VBN
cord-335871-zieuc7vk	113	9	shown	show	VBN
cord-335871-zieuc7vk	113	10	to	to	TO
cord-335871-zieuc7vk	113	11	vary	vary	VB
cord-335871-zieuc7vk	113	12	between	between	IN
cord-335871-zieuc7vk	113	13	cell	cell	NN
cord-335871-zieuc7vk	113	14	types	type	NNS
cord-335871-zieuc7vk	113	15	,	,	,
cord-335871-zieuc7vk	113	16	with	with	IN
cord-335871-zieuc7vk	113	17	myeloid	myeloid	JJ
cord-335871-zieuc7vk	113	18	and	and	CC
cord-335871-zieuc7vk	113	19	lymphoid	lymphoid	JJ
cord-335871-zieuc7vk	113	20	cells	cell	NNS
cord-335871-zieuc7vk	113	21	being	be	VBG
cord-335871-zieuc7vk	113	22	more	more	RBR
cord-335871-zieuc7vk	113	23	sensitive	sensitive	JJ
cord-335871-zieuc7vk	113	24	to	to	IN
cord-335871-zieuc7vk	113	25	gliotoxin	gliotoxin	NN
cord-335871-zieuc7vk	113	26	-	-	HYPH
cord-335871-zieuc7vk	113	27	mediated	mediate	VBN
cord-335871-zieuc7vk	113	28	NF	nf	NN
cord-335871-zieuc7vk	113	29	-	-	HYPH
cord-335871-zieuc7vk	113	30	κB	κb	CD
cord-335871-zieuc7vk	113	31	inhibition	inhibition	NN
cord-335871-zieuc7vk	113	32	than	than	IN
cord-335871-zieuc7vk	113	33	epithelial	epithelial	JJ
cord-335871-zieuc7vk	113	34	cells	cell	NNS
cord-335871-zieuc7vk	113	35	[	[	-LRB-
cord-335871-zieuc7vk	113	36	61	61	CD
cord-335871-zieuc7vk	113	37	,	,	,
cord-335871-zieuc7vk	113	38	62	62	CD
cord-335871-zieuc7vk	113	39	]	]	-RRB-
cord-335871-zieuc7vk	113	40	.	.	.
cord-335871-zieuc7vk	114	1	However	however	RB
cord-335871-zieuc7vk	114	2	,	,	,
cord-335871-zieuc7vk	114	3	this	this	DT
cord-335871-zieuc7vk	114	4	irreversible	irreversible	JJ
cord-335871-zieuc7vk	114	5	inhibition	inhibition	NN
cord-335871-zieuc7vk	114	6	may	may	MD
cord-335871-zieuc7vk	114	7	quench	quench	VB
cord-335871-zieuc7vk	114	8	the	the	DT
cord-335871-zieuc7vk	114	9	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	114	10	response	response	NN
cord-335871-zieuc7vk	114	11	and	and	CC
cord-335871-zieuc7vk	114	12	increase	increase	VB
cord-335871-zieuc7vk	114	13	susceptibility	susceptibility	NN
cord-335871-zieuc7vk	114	14	to	to	IN
cord-335871-zieuc7vk	114	15	secondary	secondary	JJ
cord-335871-zieuc7vk	114	16	infections	infection	NNS
cord-335871-zieuc7vk	114	17	.	.	.
cord-335871-zieuc7vk	115	1	HOIPINs	hoipin	NNS
cord-335871-zieuc7vk	115	2	are	be	VBP
cord-335871-zieuc7vk	115	3	synthetic	synthetic	JJ
cord-335871-zieuc7vk	115	4	small	small	JJ
cord-335871-zieuc7vk	115	5	molecules	molecule	NNS
cord-335871-zieuc7vk	115	6	that	that	WDT
cord-335871-zieuc7vk	115	7	reversibly	reversibly	RB
cord-335871-zieuc7vk	115	8	inhibit	inhibit	VBP
cord-335871-zieuc7vk	115	9	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	115	10	though	though	IN
cord-335871-zieuc7vk	115	11	targeting	target	VBG
cord-335871-zieuc7vk	115	12	of	of	IN
cord-335871-zieuc7vk	115	13	HOIP	HOIP	NNP
cord-335871-zieuc7vk	115	14	activity	activity	NN
cord-335871-zieuc7vk	115	15	,	,	,
cord-335871-zieuc7vk	115	16	displaying	display	VBG
cord-335871-zieuc7vk	115	17	both	both	CC
cord-335871-zieuc7vk	115	18	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	115	19	specificity	specificity	NN
cord-335871-zieuc7vk	115	20	as	as	RB
cord-335871-zieuc7vk	115	21	well	well	RB
cord-335871-zieuc7vk	115	22	as	as	IN
cord-335871-zieuc7vk	115	23	low	low	JJ
cord-335871-zieuc7vk	115	24	cytotoxicity	cytotoxicity	NN
cord-335871-zieuc7vk	115	25	.	.	.
cord-335871-zieuc7vk	116	1	Several	several	JJ
cord-335871-zieuc7vk	116	2	derivatives	derivative	NNS
cord-335871-zieuc7vk	116	3	have	have	VBP
cord-335871-zieuc7vk	116	4	been	be	VBN
cord-335871-zieuc7vk	116	5	made	make	VBN
cord-335871-zieuc7vk	116	6	with	with	IN
cord-335871-zieuc7vk	116	7	varying	vary	VBG
cord-335871-zieuc7vk	116	8	degrees	degree	NNS
cord-335871-zieuc7vk	116	9	of	of	IN
cord-335871-zieuc7vk	116	10	efficacy	efficacy	NN
cord-335871-zieuc7vk	116	11	(	(	-LRB-
cord-335871-zieuc7vk	116	12	HOIPIN-1	HOIPIN-1	NNP
cord-335871-zieuc7vk	116	13	-	-	HYPH
cord-335871-zieuc7vk	116	14	8	8	CD
cord-335871-zieuc7vk	116	15	)	)	-RRB-
cord-335871-zieuc7vk	116	16	,	,	,
cord-335871-zieuc7vk	116	17	with	with	IN
cord-335871-zieuc7vk	116	18	HOIPIN-8	HOIPIN-8	NNS
cord-335871-zieuc7vk	116	19	showing	show	VBG
cord-335871-zieuc7vk	116	20	significantly	significantly	RB
cord-335871-zieuc7vk	116	21	enhanced	enhance	VBN
cord-335871-zieuc7vk	116	22	ability	ability	NN
cord-335871-zieuc7vk	116	23	to	to	TO
cord-335871-zieuc7vk	116	24	prevent	prevent	VB
cord-335871-zieuc7vk	116	25	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	116	26	-	-	HYPH
cord-335871-zieuc7vk	116	27	mediated	mediate	VBN
cord-335871-zieuc7vk	116	28	NF	nf	NN
cord-335871-zieuc7vk	116	29	-	-	HYPH
cord-335871-zieuc7vk	116	30	κB	κb	CD
cord-335871-zieuc7vk	116	31	activation	activation	NN
cord-335871-zieuc7vk	116	32	in	in	IN
cord-335871-zieuc7vk	116	33	response	response	NN
cord-335871-zieuc7vk	116	34	to	to	IN
cord-335871-zieuc7vk	116	35	TNF	TNF	NNP
cord-335871-zieuc7vk	116	36	-	-	HYPH
cord-335871-zieuc7vk	116	37	α	α	NN
cord-335871-zieuc7vk	116	38	without	without	IN
cord-335871-zieuc7vk	116	39	cytotoxicity	cytotoxicity	NN
cord-335871-zieuc7vk	116	40	compared	compare	VBN
cord-335871-zieuc7vk	116	41	to	to	IN
cord-335871-zieuc7vk	116	42	the	the	DT
cord-335871-zieuc7vk	116	43	other	other	JJ
cord-335871-zieuc7vk	116	44	derivatives	derivative	NNS
cord-335871-zieuc7vk	116	45	in	in	IN
cord-335871-zieuc7vk	116	46	vitro	vitro	FW
cord-335871-zieuc7vk	116	47	[	[	-LRB-
cord-335871-zieuc7vk	116	48	57	57	CD
cord-335871-zieuc7vk	116	49	]	]	-RRB-
cord-335871-zieuc7vk	116	50	.	.	.
cord-335871-zieuc7vk	117	1	Conversely	conversely	RB
cord-335871-zieuc7vk	117	2	,	,	,
cord-335871-zieuc7vk	117	3	stapled	staple	VBD
cord-335871-zieuc7vk	117	4	α	α	NN
cord-335871-zieuc7vk	117	5	-	-	HYPH
cord-335871-zieuc7vk	117	6	helical	helical	JJ
cord-335871-zieuc7vk	117	7	peptides	peptide	NNS
cord-335871-zieuc7vk	117	8	developed	develop	VBD
cord-335871-zieuc7vk	117	9	based	base	VBN
cord-335871-zieuc7vk	117	10	on	on	IN
cord-335871-zieuc7vk	117	11	specific	specific	JJ
cord-335871-zieuc7vk	117	12	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	117	13	structures	structure	NNS
cord-335871-zieuc7vk	117	14	disrupt	disrupt	VBP
cord-335871-zieuc7vk	117	15	interactions	interaction	NNS
cord-335871-zieuc7vk	117	16	necessary	necessary	JJ
cord-335871-zieuc7vk	117	17	for	for	IN
cord-335871-zieuc7vk	117	18	stable	stable	JJ
cord-335871-zieuc7vk	117	19	complex	complex	JJ
cord-335871-zieuc7vk	117	20	formation	formation	NN
cord-335871-zieuc7vk	117	21	[	[	-LRB-
cord-335871-zieuc7vk	117	22	56	56	CD
cord-335871-zieuc7vk	117	23	,	,	,
cord-335871-zieuc7vk	117	24	63	63	CD
cord-335871-zieuc7vk	117	25	]	]	-RRB-
cord-335871-zieuc7vk	117	26	.	.	.
cord-335871-zieuc7vk	118	1	Stapled	stapled	JJ
cord-335871-zieuc7vk	118	2	peptides	peptide	NNS
cord-335871-zieuc7vk	118	3	are	be	VBP
cord-335871-zieuc7vk	118	4	a	a	DT
cord-335871-zieuc7vk	118	5	class	class	NN
cord-335871-zieuc7vk	118	6	of	of	IN
cord-335871-zieuc7vk	118	7	synthetic	synthetic	JJ
cord-335871-zieuc7vk	118	8	macrocycles	macrocycle	NNS
cord-335871-zieuc7vk	118	9	where	where	WRB
cord-335871-zieuc7vk	118	10	the	the	DT
cord-335871-zieuc7vk	118	11	secondary	secondary	JJ
cord-335871-zieuc7vk	118	12	α	α	NN
cord-335871-zieuc7vk	118	13	-	-	HYPH
cord-335871-zieuc7vk	118	14	helix	helix	NN
cord-335871-zieuc7vk	118	15	structure	structure	NN
cord-335871-zieuc7vk	118	16	is	be	VBZ
cord-335871-zieuc7vk	118	17	stabilized	stabilize	VBN
cord-335871-zieuc7vk	118	18	by	by	IN
cord-335871-zieuc7vk	118	19	the	the	DT
cord-335871-zieuc7vk	118	20	introduction	introduction	NN
cord-335871-zieuc7vk	118	21	of	of	IN
cord-335871-zieuc7vk	118	22	a	a	DT
cord-335871-zieuc7vk	118	23	hydrophobic	hydrophobic	JJ
cord-335871-zieuc7vk	118	24	bridge	bridge	NN
cord-335871-zieuc7vk	118	25	or	or	CC
cord-335871-zieuc7vk	118	26	"	"	``
cord-335871-zieuc7vk	118	27	staple	staple	JJ
cord-335871-zieuc7vk	118	28	"	"	''
cord-335871-zieuc7vk	118	29	that	that	WDT
cord-335871-zieuc7vk	118	30	rigidifies	rigidify	VBZ
cord-335871-zieuc7vk	118	31	specific	specific	JJ
cord-335871-zieuc7vk	118	32	areas	area	NNS
cord-335871-zieuc7vk	118	33	to	to	TO
cord-335871-zieuc7vk	118	34	inhibit	inhibit	VB
cord-335871-zieuc7vk	118	35	protein	protein	NN
cord-335871-zieuc7vk	118	36	:	:	:
cord-335871-zieuc7vk	118	37	protein	protein	NN
cord-335871-zieuc7vk	118	38	interactions	interaction	NNS
cord-335871-zieuc7vk	118	39	[	[	-LRB-
cord-335871-zieuc7vk	118	40	56	56	CD
cord-335871-zieuc7vk	118	41	]	]	-RRB-
cord-335871-zieuc7vk	118	42	.	.	.
cord-335871-zieuc7vk	119	1	Stapled	stapled	JJ
cord-335871-zieuc7vk	119	2	peptides	peptide	NNS
cord-335871-zieuc7vk	119	3	based	base	VBN
cord-335871-zieuc7vk	119	4	on	on	IN
cord-335871-zieuc7vk	119	5	the	the	DT
cord-335871-zieuc7vk	119	6	HOIP	HOIP	NNP
cord-335871-zieuc7vk	119	7	ubiquitin	ubiquitin	NN
cord-335871-zieuc7vk	119	8	binding	binding	NN
cord-335871-zieuc7vk	119	9	domain	domain	NN
cord-335871-zieuc7vk	119	10	have	have	VBP
cord-335871-zieuc7vk	119	11	been	be	VBN
cord-335871-zieuc7vk	119	12	shown	show	VBN
cord-335871-zieuc7vk	119	13	to	to	TO
cord-335871-zieuc7vk	119	14	successfully	successfully	RB
cord-335871-zieuc7vk	119	15	inhibit	inhibit	VB
cord-335871-zieuc7vk	119	16	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	119	17	activity	activity	NN
cord-335871-zieuc7vk	119	18	in	in	IN
cord-335871-zieuc7vk	119	19	vitro	vitro	FW
cord-335871-zieuc7vk	119	20	by	by	IN
cord-335871-zieuc7vk	119	21	disrupting	disrupt	VBG
cord-335871-zieuc7vk	119	22	its	-PRON-	PRP$
cord-335871-zieuc7vk	119	23	interaction	interaction	NN
cord-335871-zieuc7vk	119	24	with	with	IN
cord-335871-zieuc7vk	119	25	HOIL-1L	HOIL-1L	NNP
cord-335871-zieuc7vk	119	26	and	and	CC
cord-335871-zieuc7vk	119	27	destabilizing	destabilize	VBG
cord-335871-zieuc7vk	119	28	the	the	DT
cord-335871-zieuc7vk	119	29	overall	overall	JJ
cord-335871-zieuc7vk	119	30	complex	complex	NN
cord-335871-zieuc7vk	119	31	[	[	-LRB-
cord-335871-zieuc7vk	119	32	56	56	CD
cord-335871-zieuc7vk	119	33	,	,	,
cord-335871-zieuc7vk	119	34	63	63	CD
cord-335871-zieuc7vk	119	35	]	]	-RRB-
cord-335871-zieuc7vk	119	36	.	.	.
cord-335871-zieuc7vk	120	1	While	while	IN
cord-335871-zieuc7vk	120	2	several	several	JJ
cord-335871-zieuc7vk	120	3	inhibitors	inhibitor	NNS
cord-335871-zieuc7vk	120	4	of	of	IN
cord-335871-zieuc7vk	120	5	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	120	6	have	have	VBP
cord-335871-zieuc7vk	120	7	been	be	VBN
cord-335871-zieuc7vk	120	8	developed	develop	VBN
cord-335871-zieuc7vk	120	9	and	and	CC
cord-335871-zieuc7vk	120	10	shown	show	VBN
cord-335871-zieuc7vk	120	11	promise	promise	NN
cord-335871-zieuc7vk	120	12	in	in	IN
cord-335871-zieuc7vk	120	13	vitro	vitro	FW
cord-335871-zieuc7vk	120	14	,	,	,
cord-335871-zieuc7vk	120	15	no	no	DT
cord-335871-zieuc7vk	120	16	data	data	NN
cord-335871-zieuc7vk	120	17	is	be	VBZ
cord-335871-zieuc7vk	120	18	available	available	JJ
cord-335871-zieuc7vk	120	19	detailing	detail	VBG
cord-335871-zieuc7vk	120	20	their	-PRON-	PRP$
cord-335871-zieuc7vk	120	21	efficacy	efficacy	NN
cord-335871-zieuc7vk	120	22	in	in	IN
cord-335871-zieuc7vk	120	23	vivo	vivo	NN
cord-335871-zieuc7vk	120	24	.	.	.
cord-335871-zieuc7vk	121	1	Further	further	JJ
cord-335871-zieuc7vk	121	2	investigation	investigation	NN
cord-335871-zieuc7vk	121	3	in	in	IN
cord-335871-zieuc7vk	121	4	to	to	IN
cord-335871-zieuc7vk	121	5	these	these	DT
cord-335871-zieuc7vk	121	6	compounds	compound	NNS
cord-335871-zieuc7vk	121	7	which	which	WDT
cord-335871-zieuc7vk	121	8	target	target	VBP
cord-335871-zieuc7vk	121	9	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	121	10	stability	stability	NN
cord-335871-zieuc7vk	121	11	to	to	TO
cord-335871-zieuc7vk	121	12	modulate	modulate	VB
cord-335871-zieuc7vk	121	13	the	the	DT
cord-335871-zieuc7vk	121	14	degree	degree	NN
cord-335871-zieuc7vk	121	15	of	of	IN
cord-335871-zieuc7vk	121	16	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	121	17	activity	activity	NN
cord-335871-zieuc7vk	121	18	is	be	VBZ
cord-335871-zieuc7vk	121	19	warranted	warrant	VBN
cord-335871-zieuc7vk	121	20	as	as	IN
cord-335871-zieuc7vk	121	21	they	-PRON-	PRP
cord-335871-zieuc7vk	121	22	may	may	MD
cord-335871-zieuc7vk	121	23	be	be	VB
cord-335871-zieuc7vk	121	24	therapeutically	therapeutically	RB
cord-335871-zieuc7vk	121	25	beneficial	beneficial	JJ
cord-335871-zieuc7vk	121	26	for	for	IN
cord-335871-zieuc7vk	121	27	the	the	DT
cord-335871-zieuc7vk	121	28	treatment	treatment	NN
cord-335871-zieuc7vk	121	29	of	of	IN
cord-335871-zieuc7vk	121	30	hyper	hyper	JJ
cord-335871-zieuc7vk	121	31	-	-	JJ
cord-335871-zieuc7vk	121	32	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	121	33	response	response	NN
cord-335871-zieuc7vk	121	34	during	during	IN
cord-335871-zieuc7vk	121	35	viral	viral	JJ
cord-335871-zieuc7vk	121	36	infection	infection	NN
cord-335871-zieuc7vk	121	37	,	,	,
cord-335871-zieuc7vk	121	38	where	where	WRB
cord-335871-zieuc7vk	121	39	a	a	DT
cord-335871-zieuc7vk	121	40	graded	grade	VBN
cord-335871-zieuc7vk	121	41	host	host	NN
cord-335871-zieuc7vk	121	42	response	response	NN
cord-335871-zieuc7vk	121	43	is	be	VBZ
cord-335871-zieuc7vk	121	44	necessary	necessary	JJ
cord-335871-zieuc7vk	121	45	.	.	.
cord-335871-zieuc7vk	122	1	Within	within	IN
cord-335871-zieuc7vk	122	2	the	the	DT
cord-335871-zieuc7vk	122	3	past	past	JJ
cord-335871-zieuc7vk	122	4	150	150	CD
cord-335871-zieuc7vk	122	5	years	year	NNS
cord-335871-zieuc7vk	122	6	,	,	,
cord-335871-zieuc7vk	122	7	IAV	IAV	NNP
cord-335871-zieuc7vk	122	8	has	have	VBZ
cord-335871-zieuc7vk	122	9	been	be	VBN
cord-335871-zieuc7vk	122	10	the	the	DT
cord-335871-zieuc7vk	122	11	causative	causative	JJ
cord-335871-zieuc7vk	122	12	agent	agent	NN
cord-335871-zieuc7vk	122	13	of	of	IN
cord-335871-zieuc7vk	122	14	at	at	RB
cord-335871-zieuc7vk	122	15	least	least	RBS
cord-335871-zieuc7vk	122	16	five	five	CD
cord-335871-zieuc7vk	122	17	pandemics	pandemic	NNS
cord-335871-zieuc7vk	122	18	(	(	-LRB-
cord-335871-zieuc7vk	122	19	1889	1889	CD
cord-335871-zieuc7vk	122	20	,	,	,
cord-335871-zieuc7vk	122	21	1918	1918	CD
cord-335871-zieuc7vk	122	22	,	,	,
cord-335871-zieuc7vk	122	23	1957	1957	CD
cord-335871-zieuc7vk	122	24	,	,	,
cord-335871-zieuc7vk	122	25	1968	1968	CD
cord-335871-zieuc7vk	122	26	,	,	,
cord-335871-zieuc7vk	122	27	2009	2009	CD
cord-335871-zieuc7vk	122	28	)	)	-RRB-
cord-335871-zieuc7vk	122	29	[	[	-LRB-
cord-335871-zieuc7vk	122	30	47	47	CD
cord-335871-zieuc7vk	122	31	,	,	,
cord-335871-zieuc7vk	122	32	64	64	CD
cord-335871-zieuc7vk	122	33	]	]	-RRB-
cord-335871-zieuc7vk	122	34	.	.	.
cord-335871-zieuc7vk	123	1	In	in	IN
cord-335871-zieuc7vk	123	2	addition	addition	NN
cord-335871-zieuc7vk	123	3	to	to	IN
cord-335871-zieuc7vk	123	4	IAV	IAV	NNP
cord-335871-zieuc7vk	123	5	,	,	,
cord-335871-zieuc7vk	123	6	novel	novel	JJ
cord-335871-zieuc7vk	123	7	viral	viral	JJ
cord-335871-zieuc7vk	123	8	threats	threat	NNS
cord-335871-zieuc7vk	123	9	,	,	,
cord-335871-zieuc7vk	123	10	such	such	JJ
cord-335871-zieuc7vk	123	11	as	as	IN
cord-335871-zieuc7vk	123	12	the	the	DT
cord-335871-zieuc7vk	123	13	coronavirus	coronavirus	NN
cord-335871-zieuc7vk	123	14	outbreaks	outbreak	NNS
cord-335871-zieuc7vk	123	15	of	of	IN
cord-335871-zieuc7vk	123	16	2003	2003	CD
cord-335871-zieuc7vk	123	17	,	,	,
cord-335871-zieuc7vk	123	18	2015	2015	CD
cord-335871-zieuc7vk	123	19	and	and	CC
cord-335871-zieuc7vk	123	20	2019	2019	CD
cord-335871-zieuc7vk	123	21	,	,	,
cord-335871-zieuc7vk	123	22	quickly	quickly	RB
cord-335871-zieuc7vk	123	23	spread	spread	VBN
cord-335871-zieuc7vk	123	24	worldwide	worldwide	RB
cord-335871-zieuc7vk	123	25	before	before	IN
cord-335871-zieuc7vk	123	26	virus	virus	NN
cord-335871-zieuc7vk	123	27	-	-	HYPH
cord-335871-zieuc7vk	123	28	specific	specific	JJ
cord-335871-zieuc7vk	123	29	vaccines	vaccine	NNS
cord-335871-zieuc7vk	123	30	or	or	CC
cord-335871-zieuc7vk	123	31	pharmacological	pharmacological	JJ
cord-335871-zieuc7vk	123	32	options	option	NNS
cord-335871-zieuc7vk	123	33	could	could	MD
cord-335871-zieuc7vk	123	34	be	be	VB
cord-335871-zieuc7vk	123	35	developed	develop	VBN
cord-335871-zieuc7vk	123	36	.	.	.
cord-335871-zieuc7vk	124	1	Thus	thus	RB
cord-335871-zieuc7vk	124	2	,	,	,
cord-335871-zieuc7vk	124	3	therapies	therapy	NNS
cord-335871-zieuc7vk	124	4	that	that	WDT
cord-335871-zieuc7vk	124	5	target	target	VBP
cord-335871-zieuc7vk	124	6	conserved	conserved	JJ
cord-335871-zieuc7vk	124	7	host	host	NN
cord-335871-zieuc7vk	124	8	pathways	pathway	NNS
cord-335871-zieuc7vk	124	9	may	may	MD
cord-335871-zieuc7vk	124	10	provide	provide	VB
cord-335871-zieuc7vk	124	11	a	a	DT
cord-335871-zieuc7vk	124	12	novel	novel	JJ
cord-335871-zieuc7vk	124	13	universal	universal	JJ
cord-335871-zieuc7vk	124	14	treatment	treatment	NN
cord-335871-zieuc7vk	124	15	strategies	strategy	NNS
cord-335871-zieuc7vk	124	16	,	,	,
cord-335871-zieuc7vk	124	17	regardless	regardless	RB
cord-335871-zieuc7vk	124	18	of	of	IN
cord-335871-zieuc7vk	124	19	viral	viral	JJ
cord-335871-zieuc7vk	124	20	sequence	sequence	NN
cord-335871-zieuc7vk	124	21	.	.	.
cord-335871-zieuc7vk	125	1	Findings	finding	NNS
cord-335871-zieuc7vk	125	2	from	from	IN
cord-335871-zieuc7vk	125	3	animal	animal	NN
cord-335871-zieuc7vk	125	4	models	model	NNS
cord-335871-zieuc7vk	125	5	of	of	IN
cord-335871-zieuc7vk	125	6	IAV	IAV	NNP
cord-335871-zieuc7vk	125	7	infection	infection	NN
cord-335871-zieuc7vk	125	8	have	have	VBP
cord-335871-zieuc7vk	125	9	shown	show	VBN
cord-335871-zieuc7vk	125	10	that	that	DT
cord-335871-zieuc7vk	125	11	inhibition	inhibition	NN
cord-335871-zieuc7vk	125	12	of	of	IN
cord-335871-zieuc7vk	125	13	the	the	DT
cord-335871-zieuc7vk	125	14	exuberant	exuberant	JJ
cord-335871-zieuc7vk	125	15	host	host	NN
cord-335871-zieuc7vk	125	16	immune	immune	JJ
cord-335871-zieuc7vk	125	17	response	response	NN
cord-335871-zieuc7vk	125	18	is	be	VBZ
cord-335871-zieuc7vk	125	19	associated	associate	VBN
cord-335871-zieuc7vk	125	20	with	with	IN
cord-335871-zieuc7vk	125	21	reduced	reduce	VBN
cord-335871-zieuc7vk	125	22	lung	lung	NN
cord-335871-zieuc7vk	125	23	injury	injury	NN
cord-335871-zieuc7vk	125	24	and	and	CC
cord-335871-zieuc7vk	125	25	improved	improved	JJ
cord-335871-zieuc7vk	125	26	survival	survival	NN
cord-335871-zieuc7vk	125	27	[	[	-LRB-
cord-335871-zieuc7vk	125	28	11	11	CD
cord-335871-zieuc7vk	125	29	,	,	,
cord-335871-zieuc7vk	125	30	14	14	CD
cord-335871-zieuc7vk	125	31	,	,	,
cord-335871-zieuc7vk	125	32	27	27	CD
cord-335871-zieuc7vk	125	33	,	,	,
cord-335871-zieuc7vk	125	34	28	28	CD
cord-335871-zieuc7vk	125	35	]	]	-RRB-
cord-335871-zieuc7vk	125	36	.	.	.
cord-335871-zieuc7vk	126	1	However	however	RB
cord-335871-zieuc7vk	126	2	,	,	,
cord-335871-zieuc7vk	126	3	current	current	JJ
cord-335871-zieuc7vk	126	4	FDA	FDA	NNP
cord-335871-zieuc7vk	126	5	-	-	HYPH
cord-335871-zieuc7vk	126	6	approved	approve	VBN
cord-335871-zieuc7vk	126	7	anti	anti	JJ
cord-335871-zieuc7vk	126	8	-	-	JJ
cord-335871-zieuc7vk	126	9	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	126	10	drugs	drug	NNS
cord-335871-zieuc7vk	126	11	,	,	,
cord-335871-zieuc7vk	126	12	such	such	JJ
cord-335871-zieuc7vk	126	13	as	as	IN
cord-335871-zieuc7vk	126	14	corticosteroids	corticosteroid	NNS
cord-335871-zieuc7vk	126	15	and	and	CC
cord-335871-zieuc7vk	126	16	statins	statin	NNS
cord-335871-zieuc7vk	126	17	,	,	,
cord-335871-zieuc7vk	126	18	have	have	VBP
cord-335871-zieuc7vk	126	19	failed	fail	VBN
cord-335871-zieuc7vk	126	20	to	to	TO
cord-335871-zieuc7vk	126	21	show	show	VB
cord-335871-zieuc7vk	126	22	benefit	benefit	NN
cord-335871-zieuc7vk	126	23	during	during	IN
cord-335871-zieuc7vk	126	24	severe	severe	JJ
cord-335871-zieuc7vk	126	25	IAV	IAV	NNP
cord-335871-zieuc7vk	126	26	infection	infection	NN
cord-335871-zieuc7vk	126	27	[	[	-LRB-
cord-335871-zieuc7vk	126	28	49	49	CD
cord-335871-zieuc7vk	126	29	,	,	,
cord-335871-zieuc7vk	126	30	50	50	CD
cord-335871-zieuc7vk	126	31	]	]	-RRB-
cord-335871-zieuc7vk	126	32	.	.	.
cord-335871-zieuc7vk	127	1	Beyond	beyond	IN
cord-335871-zieuc7vk	127	2	viral	viral	JJ
cord-335871-zieuc7vk	127	3	infections	infection	NNS
cord-335871-zieuc7vk	127	4	,	,	,
cord-335871-zieuc7vk	127	5	the	the	DT
cord-335871-zieuc7vk	127	6	amplitude	amplitude	NN
cord-335871-zieuc7vk	127	7	of	of	IN
cord-335871-zieuc7vk	127	8	the	the	DT
cord-335871-zieuc7vk	127	9	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	127	10	response	response	NN
cord-335871-zieuc7vk	127	11	has	have	VBZ
cord-335871-zieuc7vk	127	12	been	be	VBN
cord-335871-zieuc7vk	127	13	shown	show	VBN
cord-335871-zieuc7vk	127	14	to	to	TO
cord-335871-zieuc7vk	127	15	be	be	VB
cord-335871-zieuc7vk	127	16	a	a	DT
cord-335871-zieuc7vk	127	17	critical	critical	JJ
cord-335871-zieuc7vk	127	18	determinant	determinant	NN
cord-335871-zieuc7vk	127	19	in	in	IN
cord-335871-zieuc7vk	127	20	outcome	outcome	NN
cord-335871-zieuc7vk	127	21	during	during	IN
cord-335871-zieuc7vk	127	22	bacterial	bacterial	JJ
cord-335871-zieuc7vk	127	23	sepsis	sepsis	NN
cord-335871-zieuc7vk	127	24	in	in	IN
cord-335871-zieuc7vk	127	25	community	community	NN
cord-335871-zieuc7vk	127	26	acquired	acquire	VBD
cord-335871-zieuc7vk	127	27	pneumonia	pneumonia	NN
cord-335871-zieuc7vk	127	28	,	,	,
cord-335871-zieuc7vk	127	29	a	a	DT
cord-335871-zieuc7vk	127	30	common	common	JJ
cord-335871-zieuc7vk	127	31	complication	complication	NN
cord-335871-zieuc7vk	127	32	post	post	NN
cord-335871-zieuc7vk	127	33	IAV	IAV	NNP
cord-335871-zieuc7vk	127	34	infection	infection	NN
cord-335871-zieuc7vk	127	35	[	[	-LRB-
cord-335871-zieuc7vk	127	36	51	51	CD
cord-335871-zieuc7vk	127	37	,	,	,
cord-335871-zieuc7vk	127	38	65	65	CD
cord-335871-zieuc7vk	127	39	]	]	-RRB-
cord-335871-zieuc7vk	127	40	.	.	.
cord-335871-zieuc7vk	128	1	Analysis	analysis	NN
cord-335871-zieuc7vk	128	2	of	of	IN
cord-335871-zieuc7vk	128	3	a	a	DT
cord-335871-zieuc7vk	128	4	cohort	cohort	NN
cord-335871-zieuc7vk	128	5	of	of	IN
cord-335871-zieuc7vk	128	6	patients	patient	NNS
cord-335871-zieuc7vk	128	7	showed	show	VBD
cord-335871-zieuc7vk	128	8	that	that	IN
cord-335871-zieuc7vk	128	9	reductions	reduction	NNS
cord-335871-zieuc7vk	128	10	in	in	IN
cord-335871-zieuc7vk	128	11	the	the	DT
cord-335871-zieuc7vk	128	12	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	128	13	response	response	NN
cord-335871-zieuc7vk	128	14	during	during	IN
cord-335871-zieuc7vk	128	15	bacterial	bacterial	JJ
cord-335871-zieuc7vk	128	16	pnumonia	pnumonia	NN
cord-335871-zieuc7vk	128	17	,	,	,
cord-335871-zieuc7vk	128	18	both	both	DT
cord-335871-zieuc7vk	128	19	due	due	IN
cord-335871-zieuc7vk	128	20	to	to	TO
cord-335871-zieuc7vk	128	21	host	host	VB
cord-335871-zieuc7vk	128	22	inability	inability	NN
cord-335871-zieuc7vk	128	23	to	to	TO
cord-335871-zieuc7vk	128	24	mount	mount	VB
cord-335871-zieuc7vk	128	25	a	a	DT
cord-335871-zieuc7vk	128	26	response	response	NN
cord-335871-zieuc7vk	128	27	or	or	CC
cord-335871-zieuc7vk	128	28	the	the	DT
cord-335871-zieuc7vk	128	29	administration	administration	NN
cord-335871-zieuc7vk	128	30	of	of	IN
cord-335871-zieuc7vk	128	31	anti	anti	JJ
cord-335871-zieuc7vk	128	32	-	-	JJ
cord-335871-zieuc7vk	128	33	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	128	34	steroids	steroid	NNS
cord-335871-zieuc7vk	128	35	,	,	,
cord-335871-zieuc7vk	128	36	lead	lead	VB
cord-335871-zieuc7vk	128	37	to	to	IN
cord-335871-zieuc7vk	128	38	increased	increase	VBN
cord-335871-zieuc7vk	128	39	mortality	mortality	NN
cord-335871-zieuc7vk	128	40	[	[	-LRB-
cord-335871-zieuc7vk	128	41	51	51	CD
cord-335871-zieuc7vk	128	42	,	,	,
cord-335871-zieuc7vk	128	43	65	65	CD
cord-335871-zieuc7vk	128	44	]	]	-RRB-
cord-335871-zieuc7vk	128	45	.	.	.
cord-335871-zieuc7vk	129	1	These	these	DT
cord-335871-zieuc7vk	129	2	clinical	clinical	JJ
cord-335871-zieuc7vk	129	3	observations	observation	NNS
cord-335871-zieuc7vk	129	4	highlight	highlight	VBP
cord-335871-zieuc7vk	129	5	the	the	DT
cord-335871-zieuc7vk	129	6	need	need	NN
cord-335871-zieuc7vk	129	7	to	to	TO
cord-335871-zieuc7vk	129	8	balance	balance	VB
cord-335871-zieuc7vk	129	9	the	the	DT
cord-335871-zieuc7vk	129	10	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	129	11	response	response	NN
cord-335871-zieuc7vk	129	12	during	during	IN
cord-335871-zieuc7vk	129	13	viral	viral	JJ
cord-335871-zieuc7vk	129	14	infection	infection	NN
cord-335871-zieuc7vk	129	15	,	,	,
cord-335871-zieuc7vk	129	16	not	not	RB
cord-335871-zieuc7vk	129	17	only	only	RB
cord-335871-zieuc7vk	129	18	to	to	TO
cord-335871-zieuc7vk	129	19	improve	improve	VB
cord-335871-zieuc7vk	129	20	lung	lung	NN
cord-335871-zieuc7vk	129	21	injury	injury	NN
cord-335871-zieuc7vk	129	22	during	during	IN
cord-335871-zieuc7vk	129	23	the	the	DT
cord-335871-zieuc7vk	129	24	primary	primary	JJ
cord-335871-zieuc7vk	129	25	viral	viral	JJ
cord-335871-zieuc7vk	129	26	infection	infection	NN
cord-335871-zieuc7vk	129	27	,	,	,
cord-335871-zieuc7vk	129	28	but	but	CC
cord-335871-zieuc7vk	129	29	also	also	RB
cord-335871-zieuc7vk	129	30	to	to	TO
cord-335871-zieuc7vk	129	31	prevent	prevent	VB
cord-335871-zieuc7vk	129	32	poor	poor	JJ
cord-335871-zieuc7vk	129	33	outcomes	outcome	NNS
cord-335871-zieuc7vk	129	34	to	to	IN
cord-335871-zieuc7vk	129	35	secondary	secondary	JJ
cord-335871-zieuc7vk	129	36	infections	infection	NNS
cord-335871-zieuc7vk	129	37	.	.	.
cord-335871-zieuc7vk	130	1	In	in	IN
cord-335871-zieuc7vk	130	2	addition	addition	NN
cord-335871-zieuc7vk	130	3	to	to	IN
cord-335871-zieuc7vk	130	4	the	the	DT
cord-335871-zieuc7vk	130	5	seasonal	seasonal	JJ
cord-335871-zieuc7vk	130	6	threat	threat	NN
cord-335871-zieuc7vk	130	7	of	of	IN
cord-335871-zieuc7vk	130	8	influenza	influenza	NN
cord-335871-zieuc7vk	130	9	,	,	,
cord-335871-zieuc7vk	130	10	we	-PRON-	PRP
cord-335871-zieuc7vk	130	11	must	must	MD
cord-335871-zieuc7vk	130	12	also	also	RB
cord-335871-zieuc7vk	130	13	be	be	VB
cord-335871-zieuc7vk	130	14	cautious	cautious	JJ
cord-335871-zieuc7vk	130	15	in	in	IN
cord-335871-zieuc7vk	130	16	the	the	DT
cord-335871-zieuc7vk	130	17	regulation	regulation	NN
cord-335871-zieuc7vk	130	18	of	of	IN
cord-335871-zieuc7vk	130	19	inflammation	inflammation	NN
cord-335871-zieuc7vk	130	20	in	in	IN
cord-335871-zieuc7vk	130	21	treatment	treatment	NN
cord-335871-zieuc7vk	130	22	of	of	IN
cord-335871-zieuc7vk	130	23	the	the	DT
cord-335871-zieuc7vk	130	24	ongoing	ongoing	JJ
cord-335871-zieuc7vk	130	25	CoVID-19	CoVID-19	NNP
cord-335871-zieuc7vk	130	26	pandemic	pandemic	NN
cord-335871-zieuc7vk	130	27	.	.	.
cord-335871-zieuc7vk	131	1	While	while	IN
cord-335871-zieuc7vk	131	2	a	a	DT
cord-335871-zieuc7vk	131	3	subgroup	subgroup	NN
cord-335871-zieuc7vk	131	4	of	of	IN
cord-335871-zieuc7vk	131	5	patients	patient	NNS
cord-335871-zieuc7vk	131	6	with	with	IN
cord-335871-zieuc7vk	131	7	severe	severe	JJ
cord-335871-zieuc7vk	131	8	COVID-19	COVID-19	NNP
cord-335871-zieuc7vk	131	9	develop	develop	VB
cord-335871-zieuc7vk	131	10	'	'	``
cord-335871-zieuc7vk	131	11	cytokine	cytokine	NN
cord-335871-zieuc7vk	131	12	storm	storm	NN
cord-335871-zieuc7vk	131	13	'	'	''
cord-335871-zieuc7vk	131	14	[	[	-LRB-
cord-335871-zieuc7vk	131	15	15	15	CD
cord-335871-zieuc7vk	131	16	,	,	,
cord-335871-zieuc7vk	131	17	16	16	CD
cord-335871-zieuc7vk	131	18	,	,	,
cord-335871-zieuc7vk	131	19	18	18	CD
cord-335871-zieuc7vk	131	20	]	]	-RRB-
cord-335871-zieuc7vk	131	21	,	,	,
cord-335871-zieuc7vk	131	22	it	-PRON-	PRP
cord-335871-zieuc7vk	131	23	must	must	MD
cord-335871-zieuc7vk	131	24	be	be	VB
cord-335871-zieuc7vk	131	25	remembered	remember	VBN
cord-335871-zieuc7vk	131	26	that	that	IN
cord-335871-zieuc7vk	131	27	current	current	JJ
cord-335871-zieuc7vk	131	28	anti	anti	JJ
cord-335871-zieuc7vk	131	29	-	-	JJ
cord-335871-zieuc7vk	131	30	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	131	31	drugs	drug	NNS
cord-335871-zieuc7vk	131	32	have	have	VBP
cord-335871-zieuc7vk	131	33	pleiotropic	pleiotropic	JJ
cord-335871-zieuc7vk	131	34	effects	effect	NNS
cord-335871-zieuc7vk	131	35	and	and	CC
cord-335871-zieuc7vk	131	36	lack	lack	VBP
cord-335871-zieuc7vk	131	37	the	the	DT
cord-335871-zieuc7vk	131	38	specificity	specificity	NN
cord-335871-zieuc7vk	131	39	needed	need	VBN
cord-335871-zieuc7vk	131	40	to	to	TO
cord-335871-zieuc7vk	131	41	carefully	carefully	RB
cord-335871-zieuc7vk	131	42	calibrate	calibrate	VB
cord-335871-zieuc7vk	131	43	the	the	DT
cord-335871-zieuc7vk	131	44	host	host	NN
cord-335871-zieuc7vk	131	45	response	response	NN
cord-335871-zieuc7vk	131	46	.	.	.
cord-335871-zieuc7vk	132	1	As	as	IN
cord-335871-zieuc7vk	132	2	such	such	JJ
cord-335871-zieuc7vk	132	3	,	,	,
cord-335871-zieuc7vk	132	4	newly	newly	RB
cord-335871-zieuc7vk	132	5	developed	develop	VBN
cord-335871-zieuc7vk	132	6	pharmacologics	pharmacologic	NNS
cord-335871-zieuc7vk	132	7	such	such	JJ
cord-335871-zieuc7vk	132	8	as	as	IN
cord-335871-zieuc7vk	132	9	those	those	DT
cord-335871-zieuc7vk	132	10	that	that	DT
cord-335871-zieuc7vk	132	11	target	target	NN
cord-335871-zieuc7vk	133	1	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	133	2	,	,	,
cord-335871-zieuc7vk	133	3	a	a	DT
cord-335871-zieuc7vk	133	4	molecular	molecular	JJ
cord-335871-zieuc7vk	133	5	rheostat	rheostat	NN
cord-335871-zieuc7vk	133	6	of	of	IN
cord-335871-zieuc7vk	133	7	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	133	8	signaling	signaling	NN
cord-335871-zieuc7vk	133	9	,	,	,
cord-335871-zieuc7vk	133	10	have	have	VBP
cord-335871-zieuc7vk	133	11	the	the	DT
cord-335871-zieuc7vk	133	12	potential	potential	NN
cord-335871-zieuc7vk	133	13	to	to	TO
cord-335871-zieuc7vk	133	14	fine	fine	JJ
cord-335871-zieuc7vk	133	15	tune	tune	NN
cord-335871-zieuc7vk	133	16	inflammation	inflammation	NN
cord-335871-zieuc7vk	133	17	and	and	CC
cord-335871-zieuc7vk	133	18	moderate	moderate	VB
cord-335871-zieuc7vk	133	19	the	the	DT
cord-335871-zieuc7vk	133	20	host	host	NN
cord-335871-zieuc7vk	133	21	response	response	NN
cord-335871-zieuc7vk	133	22	.	.	.
cord-335871-zieuc7vk	134	1	Further	further	JJ
cord-335871-zieuc7vk	134	2	investigation	investigation	NN
cord-335871-zieuc7vk	134	3	of	of	IN
cord-335871-zieuc7vk	134	4	compounds	compound	NNS
cord-335871-zieuc7vk	134	5	which	which	WDT
cord-335871-zieuc7vk	134	6	modulate	modulate	VBP
cord-335871-zieuc7vk	134	7	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	134	8	activity	activity	NN
cord-335871-zieuc7vk	134	9	is	be	VBZ
cord-335871-zieuc7vk	134	10	warranted	warrant	VBN
cord-335871-zieuc7vk	134	11	,	,	,
cord-335871-zieuc7vk	134	12	as	as	IN
cord-335871-zieuc7vk	134	13	they	-PRON-	PRP
cord-335871-zieuc7vk	134	14	may	may	MD
cord-335871-zieuc7vk	134	15	be	be	VB
cord-335871-zieuc7vk	134	16	therapeutically	therapeutically	RB
cord-335871-zieuc7vk	134	17	beneficial	beneficial	JJ
cord-335871-zieuc7vk	134	18	for	for	IN
cord-335871-zieuc7vk	134	19	the	the	DT
cord-335871-zieuc7vk	134	20	treatment	treatment	NN
cord-335871-zieuc7vk	134	21	of	of	IN
cord-335871-zieuc7vk	134	22	hyperinflammatory	hyperinflammatory	JJ
cord-335871-zieuc7vk	134	23	response	response	NN
cord-335871-zieuc7vk	134	24	during	during	IN
cord-335871-zieuc7vk	134	25	viral	viral	JJ
cord-335871-zieuc7vk	134	26	infections	infection	NNS
cord-335871-zieuc7vk	134	27	,	,	,
cord-335871-zieuc7vk	134	28	where	where	WRB
cord-335871-zieuc7vk	134	29	a	a	DT
cord-335871-zieuc7vk	134	30	milder	mild	JJR
cord-335871-zieuc7vk	134	31	host	host	NN
cord-335871-zieuc7vk	134	32	response	response	NN
cord-335871-zieuc7vk	134	33	should	should	MD
cord-335871-zieuc7vk	134	34	improve	improve	VB
cord-335871-zieuc7vk	134	35	outcomes	outcome	NNS
cord-335871-zieuc7vk	134	36	.	.	.
cord-335871-zieuc7vk	135	1	Nonventilatory	nonventilatory	JJ
cord-335871-zieuc7vk	135	2	strategies	strategy	NNS
cord-335871-zieuc7vk	135	3	for	for	IN
cord-335871-zieuc7vk	135	4	patients	patient	NNS
cord-335871-zieuc7vk	135	5	with	with	IN
cord-335871-zieuc7vk	135	6	life	life	NN
cord-335871-zieuc7vk	135	7	-	-	HYPH
cord-335871-zieuc7vk	135	8	threatening	threaten	VBG
cord-335871-zieuc7vk	135	9	2009	2009	CD
cord-335871-zieuc7vk	136	1	H1N1	H1N1	NNP
cord-335871-zieuc7vk	136	2	influenza	influenza	NN
cord-335871-zieuc7vk	136	3	and	and	CC
cord-335871-zieuc7vk	136	4	severe	severe	JJ
cord-335871-zieuc7vk	136	5	respiratory	respiratory	JJ
cord-335871-zieuc7vk	136	6	failure	failure	NN
cord-335871-zieuc7vk	136	7	Complications	complication	NNS
cord-335871-zieuc7vk	136	8	of	of	IN
cord-335871-zieuc7vk	136	9	seasonal	seasonal	JJ
cord-335871-zieuc7vk	136	10	and	and	CC
cord-335871-zieuc7vk	136	11	pandemic	pandemic	NN
cord-335871-zieuc7vk	136	12	influenza	influenza	NN
cord-335871-zieuc7vk	136	13	Pathogenesis	Pathogenesis	NNP
cord-335871-zieuc7vk	136	14	of	of	IN
cord-335871-zieuc7vk	136	15	influenza	influenza	NN
cord-335871-zieuc7vk	136	16	-	-	HYPH
cord-335871-zieuc7vk	136	17	induced	induce	VBN
cord-335871-zieuc7vk	136	18	acute	acute	JJ
cord-335871-zieuc7vk	136	19	respiratory	respiratory	JJ
cord-335871-zieuc7vk	136	20	distress	distress	NN
cord-335871-zieuc7vk	136	21	syndrome	syndrome	NN
cord-335871-zieuc7vk	137	1	An	an	DT
cord-335871-zieuc7vk	137	2	official	official	JJ
cord-335871-zieuc7vk	137	3	American	American	NNP
cord-335871-zieuc7vk	137	4	Thoracic	Thoracic	NNP
cord-335871-zieuc7vk	137	5	Society	Society	NNP
cord-335871-zieuc7vk	137	6	workshop	workshop	NN
cord-335871-zieuc7vk	137	7	report	report	NN
cord-335871-zieuc7vk	137	8	:	:	:
cord-335871-zieuc7vk	137	9	features	feature	NNS
cord-335871-zieuc7vk	137	10	and	and	CC
cord-335871-zieuc7vk	137	11	measurements	measurement	NNS
cord-335871-zieuc7vk	137	12	of	of	IN
cord-335871-zieuc7vk	137	13	experimental	experimental	JJ
cord-335871-zieuc7vk	137	14	acute	acute	JJ
cord-335871-zieuc7vk	137	15	lung	lung	NN
cord-335871-zieuc7vk	137	16	injury	injury	NN
cord-335871-zieuc7vk	137	17	in	in	IN
cord-335871-zieuc7vk	137	18	animals	animal	NNS
cord-335871-zieuc7vk	137	19	Mortality	mortality	IN
cord-335871-zieuc7vk	137	20	Trends	trend	NNS
cord-335871-zieuc7vk	137	21	of	of	IN
cord-335871-zieuc7vk	137	22	Acute	acute	JJ
cord-335871-zieuc7vk	137	23	Respiratory	respiratory	JJ
cord-335871-zieuc7vk	137	24	Distress	Distress	NNP
cord-335871-zieuc7vk	137	25	Syndrome	Syndrome	NNP
cord-335871-zieuc7vk	137	26	in	in	IN
cord-335871-zieuc7vk	137	27	the	the	DT
cord-335871-zieuc7vk	137	28	United	United	NNP
cord-335871-zieuc7vk	137	29	States	States	NNP
cord-335871-zieuc7vk	137	30	from	from	IN
cord-335871-zieuc7vk	137	31	1999	1999	CD
cord-335871-zieuc7vk	137	32	to	to	IN
cord-335871-zieuc7vk	137	33	2013	2013	CD
cord-335871-zieuc7vk	137	34	Subphenotypes	Subphenotypes	NNP
cord-335871-zieuc7vk	137	35	in	in	IN
cord-335871-zieuc7vk	137	36	acute	acute	JJ
cord-335871-zieuc7vk	137	37	respiratory	respiratory	JJ
cord-335871-zieuc7vk	137	38	distress	distress	NN
cord-335871-zieuc7vk	137	39	syndrome	syndrome	NN
cord-335871-zieuc7vk	137	40	:	:	:
cord-335871-zieuc7vk	137	41	latent	latent	JJ
cord-335871-zieuc7vk	137	42	class	class	NN
cord-335871-zieuc7vk	137	43	analysis	analysis	NN
cord-335871-zieuc7vk	137	44	of	of	IN
cord-335871-zieuc7vk	137	45	data	datum	NNS
cord-335871-zieuc7vk	137	46	from	from	IN
cord-335871-zieuc7vk	137	47	two	two	CD
cord-335871-zieuc7vk	137	48	randomised	randomised	JJ
cord-335871-zieuc7vk	137	49	controlled	control	VBN
cord-335871-zieuc7vk	137	50	trials	trial	NNS
cord-335871-zieuc7vk	138	1	Gas	gas	NN
cord-335871-zieuc7vk	138	2	Exchange	Exchange	NNP
cord-335871-zieuc7vk	138	3	Disturbances	Disturbances	NNPS
cord-335871-zieuc7vk	138	4	Regulate	regulate	VBP
cord-335871-zieuc7vk	138	5	Alveolar	alveolar	NN
cord-335871-zieuc7vk	138	6	Fluid	Fluid	NNP
cord-335871-zieuc7vk	138	7	Clearance	Clearance	NNP
cord-335871-zieuc7vk	138	8	during	during	IN
cord-335871-zieuc7vk	138	9	Acute	Acute	NNP
cord-335871-zieuc7vk	138	10	Lung	Lung	NNP
cord-335871-zieuc7vk	138	11	Injury	Injury	NNP
cord-335871-zieuc7vk	138	12	.	.	.
cord-335871-zieuc7vk	139	1	Front	Front	NNP
cord-335871-zieuc7vk	139	2	Immunol	Immunol	NNP
cord-335871-zieuc7vk	139	3	Lung	Lung	NNP
cord-335871-zieuc7vk	139	4	pathology	pathology	NN
cord-335871-zieuc7vk	139	5	in	in	IN
cord-335871-zieuc7vk	139	6	fatal	fatal	JJ
cord-335871-zieuc7vk	139	7	novel	novel	JJ
cord-335871-zieuc7vk	139	8	human	human	NN
cord-335871-zieuc7vk	139	9	influenza	influenza	NN
cord-335871-zieuc7vk	139	10	A	A	NNP
cord-335871-zieuc7vk	139	11	(	(	-LRB-
cord-335871-zieuc7vk	139	12	H1N1	H1N1	NNP
cord-335871-zieuc7vk	139	13	)	)	-RRB-
cord-335871-zieuc7vk	139	14	infection	infection	NN
cord-335871-zieuc7vk	139	15	Suppression	suppression	NN
cord-335871-zieuc7vk	139	16	of	of	IN
cord-335871-zieuc7vk	139	17	cytokine	cytokine	NN
cord-335871-zieuc7vk	139	18	storm	storm	NN
cord-335871-zieuc7vk	139	19	with	with	IN
cord-335871-zieuc7vk	139	20	a	a	DT
cord-335871-zieuc7vk	139	21	sphingosine	sphingosine	JJ
cord-335871-zieuc7vk	139	22	analog	analog	NN
cord-335871-zieuc7vk	139	23	provides	provide	VBZ
cord-335871-zieuc7vk	139	24	protection	protection	NN
cord-335871-zieuc7vk	139	25	against	against	IN
cord-335871-zieuc7vk	139	26	pathogenic	pathogenic	JJ
cord-335871-zieuc7vk	139	27	influenza	influenza	NN
cord-335871-zieuc7vk	139	28	virus	virus	NN
cord-335871-zieuc7vk	139	29	CCR2	CCR2	NNP
cord-335871-zieuc7vk	139	30	+	+	CC
cord-335871-zieuc7vk	139	31	monocyte	monocyte	NNP
cord-335871-zieuc7vk	139	32	-	-	HYPH
cord-335871-zieuc7vk	139	33	derived	derive	VBN
cord-335871-zieuc7vk	139	34	dendritic	dendritic	JJ
cord-335871-zieuc7vk	139	35	cells	cell	NNS
cord-335871-zieuc7vk	139	36	and	and	CC
cord-335871-zieuc7vk	139	37	exudate	exudate	NN
cord-335871-zieuc7vk	139	38	macrophages	macrophage	NNS
cord-335871-zieuc7vk	139	39	produce	produce	VBP
cord-335871-zieuc7vk	140	1	influenza	influenza	NN
cord-335871-zieuc7vk	140	2	-	-	HYPH
cord-335871-zieuc7vk	140	3	induced	induce	VBN
cord-335871-zieuc7vk	140	4	pulmonary	pulmonary	JJ
cord-335871-zieuc7vk	140	5	immune	immune	JJ
cord-335871-zieuc7vk	140	6	pathology	pathology	NN
cord-335871-zieuc7vk	140	7	and	and	CC
cord-335871-zieuc7vk	140	8	mortality	mortality	NN
cord-335871-zieuc7vk	140	9	Role	role	NN
cord-335871-zieuc7vk	140	10	of	of	IN
cord-335871-zieuc7vk	140	11	host	host	NN
cord-335871-zieuc7vk	140	12	immune	immune	JJ
cord-335871-zieuc7vk	140	13	response	response	NN
cord-335871-zieuc7vk	140	14	and	and	CC
cord-335871-zieuc7vk	140	15	viral	viral	JJ
cord-335871-zieuc7vk	140	16	load	load	NN
cord-335871-zieuc7vk	140	17	in	in	IN
cord-335871-zieuc7vk	140	18	the	the	DT
cord-335871-zieuc7vk	140	19	differential	differential	JJ
cord-335871-zieuc7vk	140	20	outcome	outcome	NN
cord-335871-zieuc7vk	140	21	of	of	IN
cord-335871-zieuc7vk	140	22	pandemic	pandemic	JJ
cord-335871-zieuc7vk	140	23	H1N1	H1N1	NNP
cord-335871-zieuc7vk	140	24	(	(	-LRB-
cord-335871-zieuc7vk	140	25	2009	2009	CD
cord-335871-zieuc7vk	140	26	)	)	-RRB-
cord-335871-zieuc7vk	140	27	influenza	influenza	NN
cord-335871-zieuc7vk	140	28	virus	virus	NN
cord-335871-zieuc7vk	140	29	infection	infection	NN
cord-335871-zieuc7vk	140	30	in	in	IN
cord-335871-zieuc7vk	140	31	Indian	indian	JJ
cord-335871-zieuc7vk	140	32	patients	patient	NNS
cord-335871-zieuc7vk	140	33	Fatal	fatal	JJ
cord-335871-zieuc7vk	140	34	outcome	outcome	NN
cord-335871-zieuc7vk	140	35	of	of	IN
cord-335871-zieuc7vk	140	36	human	human	JJ
cord-335871-zieuc7vk	140	37	influenza	influenza	NN
cord-335871-zieuc7vk	140	38	A	a	NN
cord-335871-zieuc7vk	140	39	(	(	-LRB-
cord-335871-zieuc7vk	140	40	H5N1	H5N1	NNP
cord-335871-zieuc7vk	140	41	)	)	-RRB-
cord-335871-zieuc7vk	140	42	is	be	VBZ
cord-335871-zieuc7vk	140	43	associated	associate	VBN
cord-335871-zieuc7vk	140	44	with	with	IN
cord-335871-zieuc7vk	140	45	high	high	JJ
cord-335871-zieuc7vk	140	46	viral	viral	JJ
cord-335871-zieuc7vk	140	47	load	load	NN
cord-335871-zieuc7vk	140	48	and	and	CC
cord-335871-zieuc7vk	140	49	hypercytokinemia	hypercytokinemia	NN
cord-335871-zieuc7vk	140	50	Aberrant	aberrant	JJ
cord-335871-zieuc7vk	140	51	innate	innate	JJ
cord-335871-zieuc7vk	140	52	immune	immune	JJ
cord-335871-zieuc7vk	140	53	response	response	NN
cord-335871-zieuc7vk	140	54	in	in	IN
cord-335871-zieuc7vk	140	55	lethal	lethal	JJ
cord-335871-zieuc7vk	140	56	infection	infection	NN
cord-335871-zieuc7vk	140	57	of	of	IN
cord-335871-zieuc7vk	140	58	macaques	macaque	NNS
cord-335871-zieuc7vk	140	59	with	with	IN
cord-335871-zieuc7vk	140	60	the	the	DT
cord-335871-zieuc7vk	140	61	1918	1918	CD
cord-335871-zieuc7vk	140	62	influenza	influenza	NN
cord-335871-zieuc7vk	140	63	virus	virus	NN
cord-335871-zieuc7vk	140	64	Clinical	clinical	JJ
cord-335871-zieuc7vk	140	65	features	feature	NNS
cord-335871-zieuc7vk	140	66	of	of	IN
cord-335871-zieuc7vk	140	67	patients	patient	NNS
cord-335871-zieuc7vk	140	68	infected	infect	VBN
cord-335871-zieuc7vk	140	69	with	with	IN
cord-335871-zieuc7vk	140	70	2019	2019	CD
cord-335871-zieuc7vk	140	71	novel	novel	JJ
cord-335871-zieuc7vk	140	72	coronavirus	coronavirus	NN
cord-335871-zieuc7vk	140	73	in	in	IN
cord-335871-zieuc7vk	140	74	Wuhan	Wuhan	NNP
cord-335871-zieuc7vk	140	75	,	,	,
cord-335871-zieuc7vk	140	76	China	China	NNP
cord-335871-zieuc7vk	140	77	.	.	.
cord-335871-zieuc7vk	141	1	Lancet	Lancet	NNP
cord-335871-zieuc7vk	141	2	Clinical	clinical	JJ
cord-335871-zieuc7vk	141	3	predictors	predictor	NNS
cord-335871-zieuc7vk	141	4	of	of	IN
cord-335871-zieuc7vk	141	5	mortality	mortality	NN
cord-335871-zieuc7vk	141	6	due	due	IN
cord-335871-zieuc7vk	141	7	to	to	IN
cord-335871-zieuc7vk	141	8	COVID-19	COVID-19	NNP
cord-335871-zieuc7vk	141	9	based	base	VBN
cord-335871-zieuc7vk	141	10	on	on	IN
cord-335871-zieuc7vk	141	11	an	an	DT
cord-335871-zieuc7vk	141	12	analysis	analysis	NN
cord-335871-zieuc7vk	141	13	of	of	IN
cord-335871-zieuc7vk	141	14	data	datum	NNS
cord-335871-zieuc7vk	141	15	of	of	IN
cord-335871-zieuc7vk	141	16	150	150	CD
cord-335871-zieuc7vk	141	17	patients	patient	NNS
cord-335871-zieuc7vk	141	18	from	from	IN
cord-335871-zieuc7vk	141	19	Wuhan	Wuhan	NNP
cord-335871-zieuc7vk	141	20	,	,	,
cord-335871-zieuc7vk	141	21	China	China	NNP
cord-335871-zieuc7vk	141	22	Baricitinib	Baricitinib	NNP
cord-335871-zieuc7vk	141	23	as	as	IN
cord-335871-zieuc7vk	141	24	potential	potential	JJ
cord-335871-zieuc7vk	141	25	treatment	treatment	NN
cord-335871-zieuc7vk	141	26	for	for	IN
cord-335871-zieuc7vk	141	27	2019-nCoV	2019-ncov	CD
cord-335871-zieuc7vk	141	28	acute	acute	JJ
cord-335871-zieuc7vk	141	29	respiratory	respiratory	JJ
cord-335871-zieuc7vk	141	30	disease	disease	NN
cord-335871-zieuc7vk	141	31	COVID-19	COVID-19	NNP
cord-335871-zieuc7vk	141	32	:	:	:
cord-335871-zieuc7vk	141	33	consider	consider	VB
cord-335871-zieuc7vk	141	34	cytokine	cytokine	JJ
cord-335871-zieuc7vk	141	35	storm	storm	NN
cord-335871-zieuc7vk	141	36	syndromes	syndrome	NNS
cord-335871-zieuc7vk	141	37	and	and	CC
cord-335871-zieuc7vk	141	38	immunosuppression	immunosuppression	NN
cord-335871-zieuc7vk	141	39	Retinoic	retinoic	JJ
cord-335871-zieuc7vk	141	40	acid	acid	NN
cord-335871-zieuc7vk	141	41	inducible	inducible	JJ
cord-335871-zieuc7vk	141	42	gene	gene	NN
cord-335871-zieuc7vk	141	43	-	-	:
cord-335871-zieuc7vk	141	44	I	i	NN
cord-335871-zieuc7vk	141	45	and	and	CC
cord-335871-zieuc7vk	141	46	mda-5	mda-5	NNP
cord-335871-zieuc7vk	141	47	are	be	VBP
cord-335871-zieuc7vk	141	48	involved	involve	VBN
cord-335871-zieuc7vk	141	49	in	in	IN
cord-335871-zieuc7vk	141	50	influenza	influenza	NN
cord-335871-zieuc7vk	141	51	A	a	DT
cord-335871-zieuc7vk	141	52	virus	virus	NN
cord-335871-zieuc7vk	141	53	-	-	HYPH
cord-335871-zieuc7vk	141	54	induced	induce	VBN
cord-335871-zieuc7vk	141	55	expression	expression	NN
cord-335871-zieuc7vk	141	56	of	of	IN
cord-335871-zieuc7vk	141	57	antiviral	antiviral	JJ
cord-335871-zieuc7vk	141	58	cytokines	cytokine	NNS
cord-335871-zieuc7vk	141	59	Actin	Actin	NNP
cord-335871-zieuc7vk	141	60	and	and	CC
cord-335871-zieuc7vk	141	61	RIG	rig	NN
cord-335871-zieuc7vk	141	62	-	-	:
cord-335871-zieuc7vk	141	63	I	I	NNP
cord-335871-zieuc7vk	141	64	/	/	SYM
cord-335871-zieuc7vk	141	65	MAVS	MAVS	NNP
cord-335871-zieuc7vk	141	66	signaling	signal	VBG
cord-335871-zieuc7vk	141	67	components	component	NNS
cord-335871-zieuc7vk	141	68	translocate	translocate	VBP
cord-335871-zieuc7vk	141	69	to	to	IN
cord-335871-zieuc7vk	141	70	mitochondria	mitochondrion	NNS
cord-335871-zieuc7vk	141	71	upon	upon	IN
cord-335871-zieuc7vk	141	72	influenza	influenza	NN
cord-335871-zieuc7vk	141	73	A	a	DT
cord-335871-zieuc7vk	141	74	virus	virus	NN
cord-335871-zieuc7vk	141	75	infection	infection	NN
cord-335871-zieuc7vk	141	76	of	of	IN
cord-335871-zieuc7vk	141	77	human	human	JJ
cord-335871-zieuc7vk	141	78	primary	primary	JJ
cord-335871-zieuc7vk	141	79	macrophages	macrophage	NNS
cord-335871-zieuc7vk	141	80	Cell	cell	NN
cord-335871-zieuc7vk	141	81	type	type	NN
cord-335871-zieuc7vk	141	82	-	-	HYPH
cord-335871-zieuc7vk	141	83	specific	specific	JJ
cord-335871-zieuc7vk	141	84	involvement	involvement	NN
cord-335871-zieuc7vk	141	85	of	of	IN
cord-335871-zieuc7vk	141	86	RIG	rig	NN
cord-335871-zieuc7vk	141	87	-	-	:
cord-335871-zieuc7vk	141	88	I	-PRON-	PRP
cord-335871-zieuc7vk	141	89	in	in	IN
cord-335871-zieuc7vk	141	90	antiviral	antiviral	JJ
cord-335871-zieuc7vk	141	91	response	response	NN
cord-335871-zieuc7vk	141	92	Pathogenic	pathogenic	JJ
cord-335871-zieuc7vk	141	93	potential	potential	NN
cord-335871-zieuc7vk	141	94	of	of	IN
cord-335871-zieuc7vk	141	95	interferon	interferon	NN
cord-335871-zieuc7vk	141	96	alphabeta	alphabeta	NN
cord-335871-zieuc7vk	141	97	in	in	IN
cord-335871-zieuc7vk	141	98	acute	acute	JJ
cord-335871-zieuc7vk	141	99	influenza	influenza	NN
cord-335871-zieuc7vk	141	100	infection	infection	NN
cord-335871-zieuc7vk	142	1	Respiratory	respiratory	JJ
cord-335871-zieuc7vk	142	2	epithelial	epithelial	JJ
cord-335871-zieuc7vk	142	3	cells	cell	NNS
cord-335871-zieuc7vk	142	4	orchestrate	orchestrate	VBP
cord-335871-zieuc7vk	142	5	pulmonary	pulmonary	JJ
cord-335871-zieuc7vk	142	6	innate	innate	JJ
cord-335871-zieuc7vk	142	7	immunity	immunity	NN
cord-335871-zieuc7vk	143	1	Innate	innate	JJ
cord-335871-zieuc7vk	143	2	immune	immune	JJ
cord-335871-zieuc7vk	143	3	sensing	sensing	NN
cord-335871-zieuc7vk	143	4	and	and	CC
cord-335871-zieuc7vk	143	5	response	response	NN
cord-335871-zieuc7vk	143	6	to	to	IN
cord-335871-zieuc7vk	143	7	influenza	influenza	NN
cord-335871-zieuc7vk	143	8	Evidence	evidence	NN
cord-335871-zieuc7vk	143	9	for	for	IN
cord-335871-zieuc7vk	143	10	phagocytosis	phagocytosis	NN
cord-335871-zieuc7vk	143	11	of	of	IN
cord-335871-zieuc7vk	143	12	influenza	influenza	NN
cord-335871-zieuc7vk	143	13	virus	virus	NN
cord-335871-zieuc7vk	143	14	-	-	HYPH
cord-335871-zieuc7vk	143	15	infected	infect	VBN
cord-335871-zieuc7vk	143	16	,	,	,
cord-335871-zieuc7vk	143	17	apoptotic	apoptotic	JJ
cord-335871-zieuc7vk	143	18	cells	cell	NNS
cord-335871-zieuc7vk	143	19	by	by	IN
cord-335871-zieuc7vk	143	20	neutrophils	neutrophil	NNS
cord-335871-zieuc7vk	143	21	and	and	CC
cord-335871-zieuc7vk	143	22	macrophages	macrophage	NNS
cord-335871-zieuc7vk	143	23	in	in	IN
cord-335871-zieuc7vk	143	24	mice	mouse	NNS
cord-335871-zieuc7vk	143	25	Activation	activation	NN
cord-335871-zieuc7vk	143	26	mechanisms	mechanism	NNS
cord-335871-zieuc7vk	143	27	of	of	IN
cord-335871-zieuc7vk	143	28	natural	natural	JJ
cord-335871-zieuc7vk	143	29	killer	killer	NN
cord-335871-zieuc7vk	143	30	cells	cell	NNS
cord-335871-zieuc7vk	143	31	during	during	IN
cord-335871-zieuc7vk	143	32	influenza	influenza	NN
cord-335871-zieuc7vk	143	33	virus	virus	NN
cord-335871-zieuc7vk	143	34	infection	infection	NN
cord-335871-zieuc7vk	143	35	Dissecting	dissect	VBG
cord-335871-zieuc7vk	143	36	influenza	influenza	NN
cord-335871-zieuc7vk	143	37	virus	virus	NN
cord-335871-zieuc7vk	143	38	pathogenesis	pathogenesis	NN
cord-335871-zieuc7vk	143	39	uncovers	uncover	VBZ
cord-335871-zieuc7vk	143	40	a	a	DT
cord-335871-zieuc7vk	143	41	novel	novel	JJ
cord-335871-zieuc7vk	143	42	chemical	chemical	NN
cord-335871-zieuc7vk	143	43	approach	approach	NN
cord-335871-zieuc7vk	143	44	to	to	TO
cord-335871-zieuc7vk	143	45	combat	combat	VB
cord-335871-zieuc7vk	143	46	the	the	DT
cord-335871-zieuc7vk	143	47	infection	infection	NN
cord-335871-zieuc7vk	144	1	FXYD5	FXYD5	NNP
cord-335871-zieuc7vk	144	2	Is	be	VBZ
cord-335871-zieuc7vk	144	3	an	an	DT
cord-335871-zieuc7vk	144	4	Essential	Essential	NNP
cord-335871-zieuc7vk	144	5	Mediator	Mediator	NNP
cord-335871-zieuc7vk	144	6	of	of	IN
cord-335871-zieuc7vk	144	7	the	the	DT
cord-335871-zieuc7vk	144	8	Inflammatory	Inflammatory	NNP
cord-335871-zieuc7vk	144	9	Response	Response	NNP
cord-335871-zieuc7vk	144	10	during	during	IN
cord-335871-zieuc7vk	144	11	Lung	Lung	NNP
cord-335871-zieuc7vk	144	12	Injury	Injury	NNP
cord-335871-zieuc7vk	144	13	.	.	.
cord-335871-zieuc7vk	145	1	Front	Front	NNP
cord-335871-zieuc7vk	145	2	Immunol	Immunol	NNP
cord-335871-zieuc7vk	145	3	Lung	Lung	NNP
cord-335871-zieuc7vk	145	4	epithelial	epithelial	JJ
cord-335871-zieuc7vk	145	5	apoptosis	apoptosis	NN
cord-335871-zieuc7vk	145	6	in	in	IN
cord-335871-zieuc7vk	145	7	influenza	influenza	NN
cord-335871-zieuc7vk	145	8	virus	virus	NN
cord-335871-zieuc7vk	145	9	pneumonia	pneumonia	NN
cord-335871-zieuc7vk	145	10	:	:	:
cord-335871-zieuc7vk	146	1	the	the	DT
cord-335871-zieuc7vk	146	2	role	role	NN
cord-335871-zieuc7vk	146	3	of	of	IN
cord-335871-zieuc7vk	146	4	macrophage	macrophage	NN
cord-335871-zieuc7vk	146	5	-	-	HYPH
cord-335871-zieuc7vk	146	6	expressed	express	VBN
cord-335871-zieuc7vk	146	7	TNFrelated	tnfrelated	JJ
cord-335871-zieuc7vk	146	8	apoptosis	apoptosis	NN
cord-335871-zieuc7vk	146	9	-	-	HYPH
cord-335871-zieuc7vk	146	10	inducing	induce	VBG
cord-335871-zieuc7vk	146	11	ligand	ligand	NN
cord-335871-zieuc7vk	146	12	Contrasting	contrast	VBG
cord-335871-zieuc7vk	146	13	effects	effect	NNS
cord-335871-zieuc7vk	146	14	of	of	IN
cord-335871-zieuc7vk	146	15	CCR5	CCR5	NNP
cord-335871-zieuc7vk	146	16	and	and	CC
cord-335871-zieuc7vk	146	17	CCR2	CCR2	NNP
cord-335871-zieuc7vk	146	18	deficiency	deficiency	NN
cord-335871-zieuc7vk	146	19	in	in	IN
cord-335871-zieuc7vk	146	20	the	the	DT
cord-335871-zieuc7vk	146	21	pulmonary	pulmonary	JJ
cord-335871-zieuc7vk	146	22	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	146	23	response	response	NN
cord-335871-zieuc7vk	146	24	to	to	TO
cord-335871-zieuc7vk	146	25	influenza	influenza	VB
cord-335871-zieuc7vk	146	26	A	a	DT
cord-335871-zieuc7vk	146	27	virus	virus	NN
cord-335871-zieuc7vk	146	28	NK	NK	NNP
cord-335871-zieuc7vk	146	29	cells	cell	NNS
cord-335871-zieuc7vk	146	30	exacerbate	exacerbate	VBP
cord-335871-zieuc7vk	146	31	the	the	DT
cord-335871-zieuc7vk	146	32	pathology	pathology	NN
cord-335871-zieuc7vk	146	33	of	of	IN
cord-335871-zieuc7vk	146	34	influenza	influenza	NN
cord-335871-zieuc7vk	146	35	virus	virus	NN
cord-335871-zieuc7vk	146	36	infection	infection	NN
cord-335871-zieuc7vk	146	37	in	in	IN
cord-335871-zieuc7vk	146	38	mice	mouse	NNS
cord-335871-zieuc7vk	146	39	RING	ring	NN
cord-335871-zieuc7vk	146	40	-	-	HYPH
cord-335871-zieuc7vk	146	41	between	between	IN
cord-335871-zieuc7vk	146	42	-	-	HYPH
cord-335871-zieuc7vk	146	43	RINGs	ring	NNS
cord-335871-zieuc7vk	146	44	--	--	:
cord-335871-zieuc7vk	146	45	keeping	keep	VBG
cord-335871-zieuc7vk	146	46	the	the	DT
cord-335871-zieuc7vk	146	47	safety	safety	NN
cord-335871-zieuc7vk	146	48	on	on	IN
cord-335871-zieuc7vk	146	49	loaded	loaded	JJ
cord-335871-zieuc7vk	146	50	guns	gun	NNS
cord-335871-zieuc7vk	146	51	SHARPIN	SHARPIN	NNS
cord-335871-zieuc7vk	146	52	forms	form	VBZ
cord-335871-zieuc7vk	146	53	a	a	DT
cord-335871-zieuc7vk	146	54	linear	linear	JJ
cord-335871-zieuc7vk	146	55	ubiquitin	ubiquitin	NN
cord-335871-zieuc7vk	146	56	ligase	ligase	NN
cord-335871-zieuc7vk	146	57	complex	complex	JJ
cord-335871-zieuc7vk	146	58	regulating	regulate	VBG
cord-335871-zieuc7vk	146	59	NF	nf	NN
cord-335871-zieuc7vk	146	60	-	-	HYPH
cord-335871-zieuc7vk	146	61	kappaB	kappaB	NNP
cord-335871-zieuc7vk	146	62	activity	activity	NN
cord-335871-zieuc7vk	146	63	and	and	CC
cord-335871-zieuc7vk	146	64	apoptosis	apoptosis	NN
cord-335871-zieuc7vk	146	65	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	146	66	,	,	,
cord-335871-zieuc7vk	146	67	a	a	DT
cord-335871-zieuc7vk	146	68	novel	novel	JJ
cord-335871-zieuc7vk	146	69	ubiquitin	ubiquitin	NN
cord-335871-zieuc7vk	146	70	ligase	ligase	NN
cord-335871-zieuc7vk	146	71	for	for	IN
cord-335871-zieuc7vk	146	72	linear	linear	JJ
cord-335871-zieuc7vk	146	73	ubiquitination	ubiquitination	NN
cord-335871-zieuc7vk	146	74	,	,	,
cord-335871-zieuc7vk	146	75	is	be	VBZ
cord-335871-zieuc7vk	146	76	crucial	crucial	JJ
cord-335871-zieuc7vk	146	77	for	for	IN
cord-335871-zieuc7vk	146	78	inflammation	inflammation	NN
cord-335871-zieuc7vk	146	79	and	and	CC
cord-335871-zieuc7vk	146	80	immune	immune	JJ
cord-335871-zieuc7vk	146	81	responses	response	NNS
cord-335871-zieuc7vk	146	82	.	.	.
cord-335871-zieuc7vk	147	1	Microbes	microbe	NNS
cord-335871-zieuc7vk	147	2	Infect	infect	VBP
cord-335871-zieuc7vk	147	3	Role	role	NN
cord-335871-zieuc7vk	147	4	of	of	IN
cord-335871-zieuc7vk	147	5	Linear	Linear	NNP
cord-335871-zieuc7vk	147	6	Ubiquitination	Ubiquitination	NNP
cord-335871-zieuc7vk	147	7	in	in	IN
cord-335871-zieuc7vk	147	8	Health	Health	NNP
cord-335871-zieuc7vk	147	9	and	and	CC
cord-335871-zieuc7vk	147	10	Disease	Disease	NNP
cord-335871-zieuc7vk	147	11	Linear	Linear	NNP
cord-335871-zieuc7vk	147	12	ubiquitin	ubiquitin	NN
cord-335871-zieuc7vk	147	13	assembly	assembly	NN
cord-335871-zieuc7vk	147	14	complex	complex	NN
cord-335871-zieuc7vk	147	15	regulates	regulate	VBZ
cord-335871-zieuc7vk	147	16	lung	lung	NN
cord-335871-zieuc7vk	147	17	epithelial	epithelial	NN
cord-335871-zieuc7vk	147	18	-	-	HYPH
cord-335871-zieuc7vk	147	19	driven	drive	VBN
cord-335871-zieuc7vk	147	20	responses	response	NNS
cord-335871-zieuc7vk	147	21	during	during	IN
cord-335871-zieuc7vk	147	22	influenza	influenza	NN
cord-335871-zieuc7vk	147	23	infection	infection	NN
cord-335871-zieuc7vk	148	1	The	the	DT
cord-335871-zieuc7vk	148	2	airway	airway	NN
cord-335871-zieuc7vk	148	3	epithelium	epithelium	NN
cord-335871-zieuc7vk	148	4	:	:	:
cord-335871-zieuc7vk	148	5	soldier	soldier	NN
cord-335871-zieuc7vk	148	6	in	in	IN
cord-335871-zieuc7vk	148	7	the	the	DT
cord-335871-zieuc7vk	148	8	fight	fight	NN
cord-335871-zieuc7vk	148	9	against	against	IN
cord-335871-zieuc7vk	148	10	respiratory	respiratory	JJ
cord-335871-zieuc7vk	148	11	viruses	virus	NNS
cord-335871-zieuc7vk	148	12	Alveolar	alveolar	VBP
cord-335871-zieuc7vk	148	13	epithelial	epithelial	JJ
cord-335871-zieuc7vk	148	14	cells	cell	NNS
cord-335871-zieuc7vk	148	15	:	:	:
cord-335871-zieuc7vk	148	16	master	master	NN
cord-335871-zieuc7vk	148	17	regulators	regulator	NNS
cord-335871-zieuc7vk	148	18	of	of	IN
cord-335871-zieuc7vk	148	19	lung	lung	NN
cord-335871-zieuc7vk	148	20	homeostasis	homeostasis	NN
cord-335871-zieuc7vk	148	21	Alveolar	Alveolar	NNP
cord-335871-zieuc7vk	148	22	Edema	edema	NN
cord-335871-zieuc7vk	148	23	Must	Must	MD
cord-335871-zieuc7vk	148	24	Be	be	VB
cord-335871-zieuc7vk	148	25	Cleared	clear	VBN
cord-335871-zieuc7vk	148	26	for	for	IN
cord-335871-zieuc7vk	148	27	the	the	DT
cord-335871-zieuc7vk	148	28	Acute	acute	JJ
cord-335871-zieuc7vk	148	29	Respiratory	Respiratory	NNP
cord-335871-zieuc7vk	148	30	Distress	Distress	NNP
cord-335871-zieuc7vk	148	31	Syndrome	Syndrome	NNP
cord-335871-zieuc7vk	148	32	Patient	Patient	NNP
cord-335871-zieuc7vk	148	33	to	to	TO
cord-335871-zieuc7vk	148	34	Survive	survive	VB
cord-335871-zieuc7vk	148	35	Recruitment	Recruitment	NNP
cord-335871-zieuc7vk	148	36	of	of	IN
cord-335871-zieuc7vk	148	37	the	the	DT
cord-335871-zieuc7vk	148	38	linear	linear	JJ
cord-335871-zieuc7vk	148	39	ubiquitin	ubiquitin	NN
cord-335871-zieuc7vk	148	40	chain	chain	NN
cord-335871-zieuc7vk	148	41	assembly	assembly	NN
cord-335871-zieuc7vk	148	42	complex	complex	NN
cord-335871-zieuc7vk	148	43	stabilizes	stabilize	VBZ
cord-335871-zieuc7vk	148	44	the	the	DT
cord-335871-zieuc7vk	148	45	TNF	TNF	NNP
cord-335871-zieuc7vk	148	46	-	-	HYPH
cord-335871-zieuc7vk	148	47	R1	R1	NNP
cord-335871-zieuc7vk	148	48	signaling	signal	VBG
cord-335871-zieuc7vk	148	49	complex	complex	NN
cord-335871-zieuc7vk	148	50	and	and	CC
cord-335871-zieuc7vk	148	51	is	be	VBZ
cord-335871-zieuc7vk	148	52	required	require	VBN
cord-335871-zieuc7vk	148	53	for	for	IN
cord-335871-zieuc7vk	148	54	TNF	TNF	NNP
cord-335871-zieuc7vk	148	55	-	-	HYPH
cord-335871-zieuc7vk	148	56	mediated	mediate	VBN
cord-335871-zieuc7vk	148	57	gene	gene	NN
cord-335871-zieuc7vk	148	58	induction	induction	NN
cord-335871-zieuc7vk	148	59	Analysis	Analysis	NNP
cord-335871-zieuc7vk	148	60	of	of	IN
cord-335871-zieuc7vk	148	61	nuclear	nuclear	JJ
cord-335871-zieuc7vk	148	62	factor	factor	NN
cord-335871-zieuc7vk	148	63	-	-	:
cord-335871-zieuc7vk	148	64	kappaB	kappaB	NNP
cord-335871-zieuc7vk	149	1	(	(	-LRB-
cord-335871-zieuc7vk	149	2	NF	NF	NNP
cord-335871-zieuc7vk	149	3	-	-	HYPH
cord-335871-zieuc7vk	149	4	kappaB	kappaB	NNP
cord-335871-zieuc7vk	149	5	)	)	-RRB-
cord-335871-zieuc7vk	149	6	essential	essential	JJ
cord-335871-zieuc7vk	149	7	modulator	modulator	NN
cord-335871-zieuc7vk	149	8	(	(	-LRB-
cord-335871-zieuc7vk	149	9	NEMO	NEMO	NNP
cord-335871-zieuc7vk	149	10	)	)	-RRB-
cord-335871-zieuc7vk	149	11	binding	bind	VBG
cord-335871-zieuc7vk	149	12	to	to	IN
cord-335871-zieuc7vk	149	13	linear	linear	JJ
cord-335871-zieuc7vk	149	14	and	and	CC
cord-335871-zieuc7vk	149	15	lysine	lysine	NN
cord-335871-zieuc7vk	149	16	-	-	HYPH
cord-335871-zieuc7vk	149	17	linked	link	VBN
cord-335871-zieuc7vk	149	18	ubiquitin	ubiquitin	NN
cord-335871-zieuc7vk	149	19	chains	chain	NNS
cord-335871-zieuc7vk	149	20	and	and	CC
cord-335871-zieuc7vk	149	21	its	-PRON-	PRP$
cord-335871-zieuc7vk	149	22	role	role	NN
cord-335871-zieuc7vk	149	23	in	in	IN
cord-335871-zieuc7vk	149	24	the	the	DT
cord-335871-zieuc7vk	149	25	activation	activation	NN
cord-335871-zieuc7vk	149	26	of	of	IN
cord-335871-zieuc7vk	149	27	NF	NF	NNP
cord-335871-zieuc7vk	149	28	-	-	HYPH
cord-335871-zieuc7vk	149	29	kappaB	kappaB	NNP
cord-335871-zieuc7vk	149	30	Involvement	Involvement	NNP
cord-335871-zieuc7vk	149	31	of	of	IN
cord-335871-zieuc7vk	149	32	linear	linear	JJ
cord-335871-zieuc7vk	149	33	polyubiquitylation	polyubiquitylation	NN
cord-335871-zieuc7vk	149	34	of	of	IN
cord-335871-zieuc7vk	149	35	NEMO	NEMO	NNP
cord-335871-zieuc7vk	149	36	in	in	IN
cord-335871-zieuc7vk	149	37	NF	NF	NNP
cord-335871-zieuc7vk	149	38	-	-	HYPH
cord-335871-zieuc7vk	149	39	kappaB	kappaB	NNP
cord-335871-zieuc7vk	149	40	activation	activation	NN
cord-335871-zieuc7vk	150	1	The	the	DT
cord-335871-zieuc7vk	150	2	E3	e3	NN
cord-335871-zieuc7vk	150	3	ligase	ligase	NN
cord-335871-zieuc7vk	150	4	HOIP	HOIP	NNP
cord-335871-zieuc7vk	150	5	specifies	specify	VBZ
cord-335871-zieuc7vk	150	6	linear	linear	JJ
cord-335871-zieuc7vk	150	7	ubiquitin	ubiquitin	NN
cord-335871-zieuc7vk	150	8	chain	chain	NN
cord-335871-zieuc7vk	150	9	assembly	assembly	NN
cord-335871-zieuc7vk	150	10	through	through	IN
cord-335871-zieuc7vk	150	11	its	-PRON-	PRP$
cord-335871-zieuc7vk	150	12	RING	ring	NN
cord-335871-zieuc7vk	150	13	-	-	HYPH
cord-335871-zieuc7vk	150	14	IBR	ibr	NN
cord-335871-zieuc7vk	150	15	-	-	HYPH
cord-335871-zieuc7vk	150	16	RING	ring	NN
cord-335871-zieuc7vk	150	17	domain	domain	NN
cord-335871-zieuc7vk	150	18	and	and	CC
cord-335871-zieuc7vk	150	19	the	the	DT
cord-335871-zieuc7vk	150	20	unique	unique	JJ
cord-335871-zieuc7vk	150	21	LDD	LDD	NNP
cord-335871-zieuc7vk	150	22	extension	extension	NN
cord-335871-zieuc7vk	151	1	Estimated	estimate	VBN
cord-335871-zieuc7vk	151	2	global	global	JJ
cord-335871-zieuc7vk	151	3	mortality	mortality	NN
cord-335871-zieuc7vk	151	4	associated	associate	VBN
cord-335871-zieuc7vk	151	5	with	with	IN
cord-335871-zieuc7vk	151	6	the	the	DT
cord-335871-zieuc7vk	151	7	first	first	JJ
cord-335871-zieuc7vk	151	8	12	12	CD
cord-335871-zieuc7vk	151	9	months	month	NNS
cord-335871-zieuc7vk	151	10	of	of	IN
cord-335871-zieuc7vk	151	11	2009	2009	CD
cord-335871-zieuc7vk	151	12	pandemic	pandemic	NN
cord-335871-zieuc7vk	151	13	influenza	influenza	NN
cord-335871-zieuc7vk	151	14	A	a	DT
cord-335871-zieuc7vk	151	15	H1N1	H1N1	NNP
cord-335871-zieuc7vk	151	16	virus	virus	NN
cord-335871-zieuc7vk	151	17	circulation	circulation	NN
cord-335871-zieuc7vk	151	18	:	:	:
cord-335871-zieuc7vk	151	19	a	a	DT
cord-335871-zieuc7vk	151	20	modelling	modelling	NN
cord-335871-zieuc7vk	151	21	study	study	NN
cord-335871-zieuc7vk	151	22	H1N1	H1N1	NNP
cord-335871-zieuc7vk	151	23	Pandemic	Pandemic	NNP
cord-335871-zieuc7vk	151	24	Timeline	Timeline	NNP
cord-335871-zieuc7vk	151	25	Estimates	estimate	NNS
cord-335871-zieuc7vk	151	26	of	of	IN
cord-335871-zieuc7vk	151	27	global	global	JJ
cord-335871-zieuc7vk	151	28	seasonal	seasonal	JJ
cord-335871-zieuc7vk	151	29	influenza	influenza	NN
cord-335871-zieuc7vk	151	30	-	-	HYPH
cord-335871-zieuc7vk	151	31	associated	associate	VBN
cord-335871-zieuc7vk	151	32	respiratory	respiratory	JJ
cord-335871-zieuc7vk	151	33	mortality	mortality	NN
cord-335871-zieuc7vk	151	34	:	:	:
cord-335871-zieuc7vk	152	1	a	a	DT
cord-335871-zieuc7vk	152	2	modelling	modelling	NN
cord-335871-zieuc7vk	152	3	study	study	NN
cord-335871-zieuc7vk	152	4	Hospitalized	hospitalize	VBD
cord-335871-zieuc7vk	152	5	patients	patient	NNS
cord-335871-zieuc7vk	152	6	with	with	IN
cord-335871-zieuc7vk	152	7	2009	2009	CD
cord-335871-zieuc7vk	152	8	H1N1	H1N1	NNP
cord-335871-zieuc7vk	152	9	influenza	influenza	NN
cord-335871-zieuc7vk	152	10	in	in	IN
cord-335871-zieuc7vk	152	11	the	the	DT
cord-335871-zieuc7vk	152	12	United	United	NNP
cord-335871-zieuc7vk	152	13	States	States	NNP
cord-335871-zieuc7vk	152	14	Influenza	Influenza	NNP
cord-335871-zieuc7vk	152	15	virus	virus	NN
cord-335871-zieuc7vk	152	16	damages	damage	VBZ
cord-335871-zieuc7vk	152	17	the	the	DT
cord-335871-zieuc7vk	152	18	alveolar	alveolar	JJ
cord-335871-zieuc7vk	152	19	barrier	barrier	NN
cord-335871-zieuc7vk	152	20	by	by	IN
cord-335871-zieuc7vk	152	21	disrupting	disrupt	VBG
cord-335871-zieuc7vk	152	22	epithelial	epithelial	JJ
cord-335871-zieuc7vk	152	23	cell	cell	NN
cord-335871-zieuc7vk	152	24	tight	tight	JJ
cord-335871-zieuc7vk	152	25	junctions	junction	NNS
cord-335871-zieuc7vk	152	26	Immunomodulatory	immunomodulatory	JJ
cord-335871-zieuc7vk	152	27	therapy	therapy	NN
cord-335871-zieuc7vk	152	28	for	for	IN
cord-335871-zieuc7vk	152	29	severe	severe	JJ
cord-335871-zieuc7vk	152	30	influenza	influenza	NN
cord-335871-zieuc7vk	152	31	Corticosteroids	Corticosteroids	NNPS
cord-335871-zieuc7vk	152	32	for	for	IN
cord-335871-zieuc7vk	152	33	severe	severe	JJ
cord-335871-zieuc7vk	152	34	influenza	influenza	NN
cord-335871-zieuc7vk	152	35	pneumonia	pneumonia	NN
cord-335871-zieuc7vk	152	36	:	:	:
cord-335871-zieuc7vk	153	1	A	a	DT
cord-335871-zieuc7vk	153	2	critical	critical	JJ
cord-335871-zieuc7vk	153	3	appraisal	appraisal	NN
cord-335871-zieuc7vk	153	4	Transcriptomic	Transcriptomic	NNP
cord-335871-zieuc7vk	153	5	Signatures	signature	NNS
cord-335871-zieuc7vk	153	6	in	in	IN
cord-335871-zieuc7vk	153	7	Sepsis	sepsis	NN
cord-335871-zieuc7vk	153	8	and	and	CC
cord-335871-zieuc7vk	153	9	a	a	DT
cord-335871-zieuc7vk	153	10	Differential	Differential	NNP
cord-335871-zieuc7vk	153	11	Response	response	NN
cord-335871-zieuc7vk	153	12	to	to	IN
cord-335871-zieuc7vk	153	13	Steroids	steroid	NNS
cord-335871-zieuc7vk	153	14	.	.	.
cord-335871-zieuc7vk	154	1	From	from	IN
cord-335871-zieuc7vk	154	2	the	the	DT
cord-335871-zieuc7vk	154	3	VANISH	VANISH	NNP
cord-335871-zieuc7vk	154	4	Randomized	Randomized	NNP
cord-335871-zieuc7vk	154	5	Trial	Trial	NNP
cord-335871-zieuc7vk	154	6	Clinical	clinical	JJ
cord-335871-zieuc7vk	154	7	evidence	evidence	NN
cord-335871-zieuc7vk	154	8	does	do	VBZ
cord-335871-zieuc7vk	154	9	not	not	RB
cord-335871-zieuc7vk	154	10	support	support	VB
cord-335871-zieuc7vk	154	11	corticosteroid	corticosteroid	NN
cord-335871-zieuc7vk	154	12	treatment	treatment	NN
cord-335871-zieuc7vk	154	13	for	for	IN
cord-335871-zieuc7vk	154	14	2019-nCoV	2019-ncov	CD
cord-335871-zieuc7vk	154	15	lung	lung	NN
cord-335871-zieuc7vk	154	16	injury	injury	NN
cord-335871-zieuc7vk	154	17	Effect	effect	NN
cord-335871-zieuc7vk	154	18	of	of	IN
cord-335871-zieuc7vk	154	19	statin	statin	NN
cord-335871-zieuc7vk	154	20	treatments	treatment	NNS
cord-335871-zieuc7vk	154	21	on	on	IN
cord-335871-zieuc7vk	154	22	highly	highly	RB
cord-335871-zieuc7vk	154	23	pathogenic	pathogenic	JJ
cord-335871-zieuc7vk	154	24	avian	avian	JJ
cord-335871-zieuc7vk	154	25	influenza	influenza	NN
cord-335871-zieuc7vk	154	26	H5N1	H5N1	NNP
cord-335871-zieuc7vk	154	27	,	,	,
cord-335871-zieuc7vk	154	28	seasonal	seasonal	JJ
cord-335871-zieuc7vk	154	29	and	and	CC
cord-335871-zieuc7vk	154	30	H1N1pdm09	H1N1pdm09	NNP
cord-335871-zieuc7vk	154	31	virus	virus	NN
cord-335871-zieuc7vk	154	32	infections	infection	NNS
cord-335871-zieuc7vk	154	33	in	in	IN
cord-335871-zieuc7vk	154	34	BALB	BALB	NNP
cord-335871-zieuc7vk	154	35	/	/	SYM
cord-335871-zieuc7vk	154	36	c	c	NN
cord-335871-zieuc7vk	154	37	mice	mouse	NNS
cord-335871-zieuc7vk	155	1	The	the	DT
cord-335871-zieuc7vk	155	2	effect	effect	NN
cord-335871-zieuc7vk	155	3	of	of	IN
cord-335871-zieuc7vk	155	4	rosuvastatin	rosuvastatin	NNS
cord-335871-zieuc7vk	155	5	in	in	IN
cord-335871-zieuc7vk	155	6	a	a	DT
cord-335871-zieuc7vk	155	7	murine	murine	JJ
cord-335871-zieuc7vk	155	8	model	model	NN
cord-335871-zieuc7vk	155	9	of	of	IN
cord-335871-zieuc7vk	155	10	influenza	influenza	NN
cord-335871-zieuc7vk	155	11	A	a	DT
cord-335871-zieuc7vk	155	12	infection	infection	NN
cord-335871-zieuc7vk	155	13	Association	Association	NNP
cord-335871-zieuc7vk	155	14	between	between	IN
cord-335871-zieuc7vk	155	15	use	use	NN
cord-335871-zieuc7vk	155	16	of	of	IN
cord-335871-zieuc7vk	155	17	statins	statin	NNS
cord-335871-zieuc7vk	155	18	and	and	CC
cord-335871-zieuc7vk	155	19	mortality	mortality	NN
cord-335871-zieuc7vk	155	20	among	among	IN
cord-335871-zieuc7vk	155	21	patients	patient	NNS
cord-335871-zieuc7vk	155	22	hospitalized	hospitalize	VBN
cord-335871-zieuc7vk	155	23	with	with	IN
cord-335871-zieuc7vk	155	24	laboratory	laboratory	NN
cord-335871-zieuc7vk	155	25	-	-	HYPH
cord-335871-zieuc7vk	155	26	confirmed	confirm	VBN
cord-335871-zieuc7vk	155	27	influenza	influenza	NN
cord-335871-zieuc7vk	155	28	virus	virus	NN
cord-335871-zieuc7vk	155	29	infections	infection	NNS
cord-335871-zieuc7vk	155	30	:	:	:
cord-335871-zieuc7vk	155	31	a	a	DT
cord-335871-zieuc7vk	155	32	multistate	multistate	JJ
cord-335871-zieuc7vk	155	33	study	study	NN
cord-335871-zieuc7vk	155	34	Biophysical	Biophysical	NNP
cord-335871-zieuc7vk	155	35	and	and	CC
cord-335871-zieuc7vk	155	36	biological	biological	JJ
cord-335871-zieuc7vk	155	37	evaluation	evaluation	NN
cord-335871-zieuc7vk	155	38	of	of	IN
cord-335871-zieuc7vk	155	39	optimized	optimize	VBN
cord-335871-zieuc7vk	155	40	stapled	stapled	JJ
cord-335871-zieuc7vk	155	41	peptide	peptide	JJ
cord-335871-zieuc7vk	155	42	inhibitors	inhibitor	NNS
cord-335871-zieuc7vk	155	43	of	of	IN
cord-335871-zieuc7vk	155	44	the	the	DT
cord-335871-zieuc7vk	155	45	linear	linear	JJ
cord-335871-zieuc7vk	155	46	ubiquitin	ubiquitin	NN
cord-335871-zieuc7vk	155	47	chain	chain	NN
cord-335871-zieuc7vk	155	48	assembly	assembly	NN
cord-335871-zieuc7vk	155	49	complex	complex	NN
cord-335871-zieuc7vk	155	50	(	(	-LRB-
cord-335871-zieuc7vk	155	51	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	155	52	)	)	-RRB-
cord-335871-zieuc7vk	156	1	Small	small	JJ
cord-335871-zieuc7vk	156	2	-	-	HYPH
cord-335871-zieuc7vk	156	3	molecule	molecule	NN
cord-335871-zieuc7vk	156	4	inhibitors	inhibitor	NNS
cord-335871-zieuc7vk	156	5	of	of	IN
cord-335871-zieuc7vk	156	6	linear	linear	JJ
cord-335871-zieuc7vk	156	7	ubiquitin	ubiquitin	NNP
cord-335871-zieuc7vk	156	8	chain	chain	NN
cord-335871-zieuc7vk	156	9	assembly	assembly	NN
cord-335871-zieuc7vk	156	10	complex	complex	NN
cord-335871-zieuc7vk	156	11	(	(	-LRB-
cord-335871-zieuc7vk	156	12	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	156	13	)	)	-RRB-
cord-335871-zieuc7vk	156	14	,	,	,
cord-335871-zieuc7vk	156	15	HOIPINs	HOIPINs	NNP
cord-335871-zieuc7vk	156	16	,	,	,
cord-335871-zieuc7vk	156	17	suppress	suppress	VB
cord-335871-zieuc7vk	156	18	NF	nf	NN
cord-335871-zieuc7vk	156	19	-	-	HYPH
cord-335871-zieuc7vk	156	20	kappaB	kappaB	NNP
cord-335871-zieuc7vk	156	21	signaling	signal	VBG
cord-335871-zieuc7vk	156	22	The	the	DT
cord-335871-zieuc7vk	156	23	anti	anti	JJ
cord-335871-zieuc7vk	156	24	-	-	JJ
cord-335871-zieuc7vk	156	25	inflammatory	inflammatory	JJ
cord-335871-zieuc7vk	156	26	drug	drug	NN
cord-335871-zieuc7vk	156	27	BAY	BAY	NNP
cord-335871-zieuc7vk	156	28	11	11	CD
cord-335871-zieuc7vk	156	29	-	-	HYPH
cord-335871-zieuc7vk	156	30	7082	7082	CD
cord-335871-zieuc7vk	156	31	suppresses	suppress	VBZ
cord-335871-zieuc7vk	156	32	the	the	DT
cord-335871-zieuc7vk	156	33	MyD88-dependent	MyD88-dependent	NNP
cord-335871-zieuc7vk	156	34	signalling	signal	VBG
cord-335871-zieuc7vk	156	35	network	network	NN
cord-335871-zieuc7vk	156	36	by	by	IN
cord-335871-zieuc7vk	156	37	targeting	target	VBG
cord-335871-zieuc7vk	156	38	the	the	DT
cord-335871-zieuc7vk	156	39	ubiquitin	ubiquitin	NN
cord-335871-zieuc7vk	156	40	system	system	NN
cord-335871-zieuc7vk	156	41	Essential	essential	JJ
cord-335871-zieuc7vk	156	42	role	role	NN
cord-335871-zieuc7vk	156	43	of	of	IN
cord-335871-zieuc7vk	156	44	the	the	DT
cord-335871-zieuc7vk	156	45	linear	linear	JJ
cord-335871-zieuc7vk	156	46	ubiquitin	ubiquitin	NN
cord-335871-zieuc7vk	156	47	chain	chain	NN
cord-335871-zieuc7vk	156	48	assembly	assembly	NN
cord-335871-zieuc7vk	156	49	complex	complex	NN
cord-335871-zieuc7vk	156	50	in	in	IN
cord-335871-zieuc7vk	156	51	lymphoma	lymphoma	NN
cord-335871-zieuc7vk	156	52	revealed	reveal	VBN
cord-335871-zieuc7vk	156	53	by	by	IN
cord-335871-zieuc7vk	156	54	rare	rare	JJ
cord-335871-zieuc7vk	156	55	germline	germline	NN
cord-335871-zieuc7vk	156	56	polymorphisms	polymorphism	NNS
cord-335871-zieuc7vk	157	1	Fragment	fragment	NN
cord-335871-zieuc7vk	157	2	-	-	HYPH
cord-335871-zieuc7vk	157	3	Based	base	VBN
cord-335871-zieuc7vk	157	4	Covalent	Covalent	NNP
cord-335871-zieuc7vk	157	5	Ligand	Ligand	NNP
cord-335871-zieuc7vk	157	6	Screening	screening	NN
cord-335871-zieuc7vk	157	7	Enables	enable	VBZ
cord-335871-zieuc7vk	157	8	Rapid	Rapid	NNP
cord-335871-zieuc7vk	157	9	Discovery	Discovery	NNP
cord-335871-zieuc7vk	157	10	of	of	IN
cord-335871-zieuc7vk	157	11	Inhibitors	Inhibitors	NNP
cord-335871-zieuc7vk	157	12	for	for	IN
cord-335871-zieuc7vk	157	13	the	the	DT
cord-335871-zieuc7vk	157	14	RBR	RBR	NNP
cord-335871-zieuc7vk	157	15	E3	e3	NN
cord-335871-zieuc7vk	157	16	Ubiquitin	Ubiquitin	NNP
cord-335871-zieuc7vk	157	17	Ligase	Ligase	NNP
cord-335871-zieuc7vk	158	1	HOIP	HOIP	NNP
cord-335871-zieuc7vk	158	2	Gliotoxin	Gliotoxin	NNP
cord-335871-zieuc7vk	158	3	suppresses	suppress	VBZ
cord-335871-zieuc7vk	158	4	NF	NF	NNP
cord-335871-zieuc7vk	158	5	-	-	HYPH
cord-335871-zieuc7vk	158	6	kappaB	kappaB	NNP
cord-335871-zieuc7vk	158	7	activation	activation	NN
cord-335871-zieuc7vk	158	8	by	by	IN
cord-335871-zieuc7vk	158	9	selectively	selectively	RB
cord-335871-zieuc7vk	158	10	inhibiting	inhibit	VBG
cord-335871-zieuc7vk	158	11	linear	linear	JJ
cord-335871-zieuc7vk	158	12	ubiquitin	ubiquitin	NN
cord-335871-zieuc7vk	158	13	chain	chain	NN
cord-335871-zieuc7vk	158	14	assembly	assembly	NN
cord-335871-zieuc7vk	158	15	complex	complex	NN
cord-335871-zieuc7vk	158	16	(	(	-LRB-
cord-335871-zieuc7vk	158	17	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	158	18	)	)	-RRB-
cord-335871-zieuc7vk	159	1	In	in	IN
cord-335871-zieuc7vk	159	2	vitro	vitro	FW
cord-335871-zieuc7vk	159	3	and	and	CC
cord-335871-zieuc7vk	159	4	in	in	IN
cord-335871-zieuc7vk	159	5	vivo	vivo	FW
cord-335871-zieuc7vk	159	6	effects	effect	NNS
cord-335871-zieuc7vk	159	7	of	of	IN
cord-335871-zieuc7vk	159	8	gliotoxin	gliotoxin	NN
cord-335871-zieuc7vk	159	9	,	,	,
cord-335871-zieuc7vk	159	10	a	a	DT
cord-335871-zieuc7vk	159	11	fungal	fungal	JJ
cord-335871-zieuc7vk	159	12	metabolite	metabolite	NN
cord-335871-zieuc7vk	159	13	:	:	:
cord-335871-zieuc7vk	159	14	efficacy	efficacy	NN
cord-335871-zieuc7vk	159	15	against	against	IN
cord-335871-zieuc7vk	159	16	dextran	dextran	NN
cord-335871-zieuc7vk	159	17	sodium	sodium	NN
cord-335871-zieuc7vk	159	18	sulfate	sulfate	NN
cord-335871-zieuc7vk	159	19	-	-	HYPH
cord-335871-zieuc7vk	159	20	induced	induce	VBN
cord-335871-zieuc7vk	159	21	colitis	colitis	NN
cord-335871-zieuc7vk	159	22	in	in	IN
cord-335871-zieuc7vk	159	23	rats	rat	NNS
cord-335871-zieuc7vk	159	24	Cooperative	Cooperative	NNP
cord-335871-zieuc7vk	159	25	Domain	Domain	NNP
cord-335871-zieuc7vk	159	26	Formation	Formation	NNP
cord-335871-zieuc7vk	159	27	by	by	IN
cord-335871-zieuc7vk	159	28	Homologous	Homologous	NNP
cord-335871-zieuc7vk	159	29	Motifs	Motifs	NNP
cord-335871-zieuc7vk	159	30	in	in	IN
cord-335871-zieuc7vk	159	31	HOIL-1L	HOIL-1L	NNP
cord-335871-zieuc7vk	160	1	and	and	CC
cord-335871-zieuc7vk	160	2	SHARPIN	SHARPIN	NNP
cord-335871-zieuc7vk	160	3	Plays	play	VBZ
cord-335871-zieuc7vk	160	4	A	a	DT
cord-335871-zieuc7vk	160	5	Crucial	crucial	JJ
cord-335871-zieuc7vk	160	6	Role	role	NN
cord-335871-zieuc7vk	160	7	in	in	IN
cord-335871-zieuc7vk	160	8	LUBAC	LUBAC	NNP
cord-335871-zieuc7vk	160	9	Stabilization	Stabilization	NNP
cord-335871-zieuc7vk	161	1	The	the	DT
cord-335871-zieuc7vk	161	2	pathology	pathology	NN
cord-335871-zieuc7vk	161	3	of	of	IN
cord-335871-zieuc7vk	161	4	influenza	influenza	NN
cord-335871-zieuc7vk	161	5	virus	virus	NN
cord-335871-zieuc7vk	161	6	infections	infection	NNS
cord-335871-zieuc7vk	161	7	Genomic	genomic	JJ
cord-335871-zieuc7vk	161	8	landscape	landscape	NN
cord-335871-zieuc7vk	161	9	of	of	IN
cord-335871-zieuc7vk	161	10	the	the	DT
cord-335871-zieuc7vk	161	11	individual	individual	JJ
cord-335871-zieuc7vk	161	12	host	host	NN
cord-335871-zieuc7vk	161	13	response	response	NN
cord-335871-zieuc7vk	161	14	and	and	CC
cord-335871-zieuc7vk	161	15	outcomes	outcome	NNS
cord-335871-zieuc7vk	161	16	in	in	IN
cord-335871-zieuc7vk	161	17	sepsis	sepsis	NN
cord-335871-zieuc7vk	161	18	:	:	:
cord-335871-zieuc7vk	161	19	a	a	DT
cord-335871-zieuc7vk	161	20	prospective	prospective	JJ
cord-335871-zieuc7vk	161	21	cohort	cohort	NN
cord-335871-zieuc7vk	161	22	study	study	NN