id sid tid token lemma pos cord-322899-uxvlagt3 1 1 key key NN cord-322899-uxvlagt3 1 2 : : : cord-322899-uxvlagt3 1 3 cord-322899-uxvlagt3 cord-322899-uxvlagt3 NNP cord-322899-uxvlagt3 1 4 authors author NNS cord-322899-uxvlagt3 1 5 : : : cord-322899-uxvlagt3 1 6 Gorji Gorji NNP cord-322899-uxvlagt3 1 7 , , , cord-322899-uxvlagt3 1 8 Ali Ali NNP cord-322899-uxvlagt3 1 9 ; ; : cord-322899-uxvlagt3 1 10 Ghadiri Ghadiri NNP cord-322899-uxvlagt3 1 11 , , , cord-322899-uxvlagt3 1 12 Maryam Maryam NNP cord-322899-uxvlagt3 1 13 Khaleghi Khaleghi NNP cord-322899-uxvlagt3 2 1 title title NN cord-322899-uxvlagt3 2 2 : : : cord-322899-uxvlagt3 2 3 The the DT cord-322899-uxvlagt3 2 4 potential potential JJ cord-322899-uxvlagt3 2 5 roles role NNS cord-322899-uxvlagt3 2 6 of of IN cord-322899-uxvlagt3 2 7 micronutrient micronutrient JJ cord-322899-uxvlagt3 2 8 deficiency deficiency NN cord-322899-uxvlagt3 2 9 and and CC cord-322899-uxvlagt3 2 10 immune immune JJ cord-322899-uxvlagt3 2 11 system system NN cord-322899-uxvlagt3 2 12 dysfunction dysfunction NN cord-322899-uxvlagt3 2 13 in in IN cord-322899-uxvlagt3 2 14 COVID-19 COVID-19 NNP cord-322899-uxvlagt3 2 15 pandemic pandemic JJ cord-322899-uxvlagt3 2 16 date date NN cord-322899-uxvlagt3 2 17 : : : cord-322899-uxvlagt3 2 18 2020 2020 CD cord-322899-uxvlagt3 2 19 - - HYPH cord-322899-uxvlagt3 2 20 11 11 CD cord-322899-uxvlagt3 2 21 - - HYPH cord-322899-uxvlagt3 2 22 06 06 CD cord-322899-uxvlagt3 2 23 journal journal NN cord-322899-uxvlagt3 2 24 : : : cord-322899-uxvlagt3 3 1 Nutrition nutrition NN cord-322899-uxvlagt3 3 2 DOI doi NN cord-322899-uxvlagt3 3 3 : : : cord-322899-uxvlagt3 3 4 10.1016 10.1016 CD cord-322899-uxvlagt3 4 1 /j.nut.2020.111047 /j.nut.2020.111047 NFP cord-322899-uxvlagt3 4 2 sha sha NN cord-322899-uxvlagt3 4 3 : : : cord-322899-uxvlagt3 5 1 5345aca3d30e09e771ba1dcc5448097ea188cc02 5345aca3d30e09e771ba1dcc5448097ea188cc02 CD cord-322899-uxvlagt3 5 2 doc_id doc_id CD cord-322899-uxvlagt3 5 3 : : : cord-322899-uxvlagt3 5 4 322899 322899 CD cord-322899-uxvlagt3 6 1 cord_uid cord_uid NN cord-322899-uxvlagt3 6 2 : : : cord-322899-uxvlagt3 7 1 uxvlagt3 uxvlagt3 NNP cord-322899-uxvlagt3 8 1 Preliminary preliminary JJ cord-322899-uxvlagt3 8 2 studies study NNS cord-322899-uxvlagt3 8 3 indicate indicate VBP cord-322899-uxvlagt3 8 4 that that IN cord-322899-uxvlagt3 8 5 a a DT cord-322899-uxvlagt3 8 6 robust robust JJ cord-322899-uxvlagt3 8 7 immune immune JJ cord-322899-uxvlagt3 8 8 response response NN cord-322899-uxvlagt3 8 9 across across IN cord-322899-uxvlagt3 8 10 different different JJ cord-322899-uxvlagt3 8 11 cell cell NN cord-322899-uxvlagt3 8 12 types type NNS cord-322899-uxvlagt3 8 13 is be VBZ cord-322899-uxvlagt3 8 14 crucial crucial JJ cord-322899-uxvlagt3 8 15 in in IN cord-322899-uxvlagt3 8 16 the the DT cord-322899-uxvlagt3 8 17 recovery recovery NN cord-322899-uxvlagt3 8 18 from from IN cord-322899-uxvlagt3 8 19 COVID-19 COVID-19 NNP cord-322899-uxvlagt3 8 20 . . . cord-322899-uxvlagt3 9 1 An an DT cord-322899-uxvlagt3 9 2 enormous enormous JJ cord-322899-uxvlagt3 9 3 number number NN cord-322899-uxvlagt3 9 4 of of IN cord-322899-uxvlagt3 9 5 investigations investigation NNS cord-322899-uxvlagt3 9 6 point point VBP cord-322899-uxvlagt3 9 7 to to IN cord-322899-uxvlagt3 9 8 the the DT cord-322899-uxvlagt3 9 9 vital vital JJ cord-322899-uxvlagt3 9 10 importance importance NN cord-322899-uxvlagt3 9 11 of of IN cord-322899-uxvlagt3 9 12 various various JJ cord-322899-uxvlagt3 9 13 micronutrients micronutrient NNS cord-322899-uxvlagt3 9 14 in in IN cord-322899-uxvlagt3 9 15 the the DT cord-322899-uxvlagt3 9 16 interactions interaction NNS cord-322899-uxvlagt3 9 17 between between IN cord-322899-uxvlagt3 9 18 the the DT cord-322899-uxvlagt3 9 19 host host NN cord-322899-uxvlagt3 9 20 immune immune JJ cord-322899-uxvlagt3 9 21 system system NN cord-322899-uxvlagt3 9 22 and and CC cord-322899-uxvlagt3 9 23 viruses virus NNS cord-322899-uxvlagt3 9 24 , , , cord-322899-uxvlagt3 9 25 including include VBG cord-322899-uxvlagt3 9 26 COVID-19 covid-19 VB cord-322899-uxvlagt3 9 27 . . . cord-322899-uxvlagt3 10 1 There there EX cord-322899-uxvlagt3 10 2 are be VBP cord-322899-uxvlagt3 10 3 complex complex JJ cord-322899-uxvlagt3 10 4 and and CC cord-322899-uxvlagt3 10 5 multifaceted multifaceted JJ cord-322899-uxvlagt3 10 6 links link NNS cord-322899-uxvlagt3 10 7 between between IN cord-322899-uxvlagt3 10 8 micronutrient micronutrient NN cord-322899-uxvlagt3 10 9 status status NN cord-322899-uxvlagt3 10 10 , , , cord-322899-uxvlagt3 10 11 the the DT cord-322899-uxvlagt3 10 12 host host NN cord-322899-uxvlagt3 10 13 immune immune JJ cord-322899-uxvlagt3 10 14 response response NN cord-322899-uxvlagt3 10 15 , , , cord-322899-uxvlagt3 10 16 and and CC cord-322899-uxvlagt3 10 17 the the DT cord-322899-uxvlagt3 10 18 virulence virulence NN cord-322899-uxvlagt3 10 19 of of IN cord-322899-uxvlagt3 10 20 pathogenic pathogenic JJ cord-322899-uxvlagt3 10 21 viruses virus NNS cord-322899-uxvlagt3 10 22 . . . cord-322899-uxvlagt3 11 1 Micronutrients micronutrient NNS cord-322899-uxvlagt3 11 2 play play VBP cord-322899-uxvlagt3 11 3 a a DT cord-322899-uxvlagt3 11 4 critical critical JJ cord-322899-uxvlagt3 11 5 role role NN cord-322899-uxvlagt3 11 6 in in IN cord-322899-uxvlagt3 11 7 the the DT cord-322899-uxvlagt3 11 8 coordinated coordinated JJ cord-322899-uxvlagt3 11 9 recruitment recruitment NN cord-322899-uxvlagt3 11 10 of of IN cord-322899-uxvlagt3 11 11 innate innate JJ cord-322899-uxvlagt3 11 12 and and CC cord-322899-uxvlagt3 11 13 adaptive adaptive JJ cord-322899-uxvlagt3 11 14 immune immune JJ cord-322899-uxvlagt3 11 15 responses response NNS cord-322899-uxvlagt3 11 16 to to IN cord-322899-uxvlagt3 11 17 viral viral JJ cord-322899-uxvlagt3 11 18 infections infection NNS cord-322899-uxvlagt3 11 19 , , , cord-322899-uxvlagt3 11 20 particularly particularly RB cord-322899-uxvlagt3 11 21 in in IN cord-322899-uxvlagt3 11 22 the the DT cord-322899-uxvlagt3 11 23 regulation regulation NN cord-322899-uxvlagt3 11 24 of of IN cord-322899-uxvlagt3 11 25 pro pro JJ cord-322899-uxvlagt3 11 26 - - JJ cord-322899-uxvlagt3 11 27 and and CC cord-322899-uxvlagt3 11 28 anti anti JJ cord-322899-uxvlagt3 11 29 - - JJ cord-322899-uxvlagt3 11 30 inflammatory inflammatory JJ cord-322899-uxvlagt3 11 31 host host NN cord-322899-uxvlagt3 11 32 responses response NNS cord-322899-uxvlagt3 11 33 . . . cord-322899-uxvlagt3 12 1 Furthermore furthermore RB cord-322899-uxvlagt3 12 2 , , , cord-322899-uxvlagt3 12 3 inadequate inadequate JJ cord-322899-uxvlagt3 12 4 amounts amount NNS cord-322899-uxvlagt3 12 5 of of IN cord-322899-uxvlagt3 12 6 micronutrients micronutrient NNS cord-322899-uxvlagt3 12 7 not not RB cord-322899-uxvlagt3 12 8 only only RB cord-322899-uxvlagt3 12 9 weaken weaken VBP cord-322899-uxvlagt3 12 10 the the DT cord-322899-uxvlagt3 12 11 immune immune JJ cord-322899-uxvlagt3 12 12 system system NN cord-322899-uxvlagt3 12 13 in in IN cord-322899-uxvlagt3 12 14 combating combat VBG cord-322899-uxvlagt3 12 15 viral viral JJ cord-322899-uxvlagt3 12 16 infections infection NNS cord-322899-uxvlagt3 12 17 , , , cord-322899-uxvlagt3 12 18 but but CC cord-322899-uxvlagt3 12 19 also also RB cord-322899-uxvlagt3 12 20 contribute contribute VB cord-322899-uxvlagt3 12 21 to to IN cord-322899-uxvlagt3 12 22 the the DT cord-322899-uxvlagt3 12 23 emergence emergence NN cord-322899-uxvlagt3 12 24 of of IN cord-322899-uxvlagt3 12 25 more more JJR cord-322899-uxvlagt3 12 26 virulent virulent JJ cord-322899-uxvlagt3 12 27 strains strain NNS cord-322899-uxvlagt3 12 28 via via IN cord-322899-uxvlagt3 12 29 alterations alteration NNS cord-322899-uxvlagt3 12 30 of of IN cord-322899-uxvlagt3 12 31 the the DT cord-322899-uxvlagt3 12 32 genetic genetic JJ cord-322899-uxvlagt3 12 33 make make NN cord-322899-uxvlagt3 12 34 - - HYPH cord-322899-uxvlagt3 12 35 up up NN cord-322899-uxvlagt3 12 36 of of IN cord-322899-uxvlagt3 12 37 the the DT cord-322899-uxvlagt3 12 38 viral viral JJ cord-322899-uxvlagt3 12 39 genome genome NN cord-322899-uxvlagt3 12 40 . . . cord-322899-uxvlagt3 13 1 This this DT cord-322899-uxvlagt3 13 2 study study NN cord-322899-uxvlagt3 13 3 aimed aim VBD cord-322899-uxvlagt3 13 4 to to TO cord-322899-uxvlagt3 13 5 evaluate evaluate VB cord-322899-uxvlagt3 13 6 the the DT cord-322899-uxvlagt3 13 7 evidence evidence NN cord-322899-uxvlagt3 13 8 which which WDT cord-322899-uxvlagt3 13 9 suggests suggest VBZ cord-322899-uxvlagt3 13 10 the the DT cord-322899-uxvlagt3 13 11 contribution contribution NN cord-322899-uxvlagt3 13 12 of of IN cord-322899-uxvlagt3 13 13 micronutrients micronutrient NNS cord-322899-uxvlagt3 13 14 in in IN cord-322899-uxvlagt3 13 15 the the DT cord-322899-uxvlagt3 13 16 spread spread NN cord-322899-uxvlagt3 13 17 as as RB cord-322899-uxvlagt3 13 18 well well RB cord-322899-uxvlagt3 13 19 as as IN cord-322899-uxvlagt3 13 20 the the DT cord-322899-uxvlagt3 13 21 morbidity morbidity NN cord-322899-uxvlagt3 13 22 and and CC cord-322899-uxvlagt3 13 23 mortality mortality NN cord-322899-uxvlagt3 13 24 of of IN cord-322899-uxvlagt3 13 25 COVID-19 COVID-19 NNP cord-322899-uxvlagt3 13 26 . . . cord-322899-uxvlagt3 14 1 Both both DT cord-322899-uxvlagt3 14 2 the the DT cord-322899-uxvlagt3 14 3 presence presence NN cord-322899-uxvlagt3 14 4 of of IN cord-322899-uxvlagt3 14 5 micronutrient micronutrient NN cord-322899-uxvlagt3 14 6 deficiencies deficiency NNS cord-322899-uxvlagt3 14 7 among among IN cord-322899-uxvlagt3 14 8 infected infected JJ cord-322899-uxvlagt3 14 9 subjects subject NNS cord-322899-uxvlagt3 14 10 and and CC cord-322899-uxvlagt3 14 11 the the DT cord-322899-uxvlagt3 14 12 effect effect NN cord-322899-uxvlagt3 14 13 of of IN cord-322899-uxvlagt3 14 14 micronutrient micronutrient JJ cord-322899-uxvlagt3 14 15 supplementation supplementation NN cord-322899-uxvlagt3 14 16 on on IN cord-322899-uxvlagt3 14 17 the the DT cord-322899-uxvlagt3 14 18 immune immune JJ cord-322899-uxvlagt3 14 19 responses response NNS cord-322899-uxvlagt3 14 20 and and CC cord-322899-uxvlagt3 14 21 overall overall JJ cord-322899-uxvlagt3 14 22 outcome outcome NN cord-322899-uxvlagt3 14 23 of of IN cord-322899-uxvlagt3 14 24 the the DT cord-322899-uxvlagt3 14 25 disease disease NN cord-322899-uxvlagt3 14 26 could could MD cord-322899-uxvlagt3 14 27 be be VB cord-322899-uxvlagt3 14 28 of of IN cord-322899-uxvlagt3 14 29 great great JJ cord-322899-uxvlagt3 14 30 interest interest NN cord-322899-uxvlagt3 14 31 to to TO cord-322899-uxvlagt3 14 32 weigh weigh VB cord-322899-uxvlagt3 14 33 the the DT cord-322899-uxvlagt3 14 34 use use NN cord-322899-uxvlagt3 14 35 of of IN cord-322899-uxvlagt3 14 36 micronutrients micronutrient NNS cord-322899-uxvlagt3 14 37 in in IN cord-322899-uxvlagt3 14 38 the the DT cord-322899-uxvlagt3 14 39 prevention prevention NN cord-322899-uxvlagt3 14 40 and and CC cord-322899-uxvlagt3 14 41 treatment treatment NN cord-322899-uxvlagt3 14 42 of of IN cord-322899-uxvlagt3 14 43 COVID-19 covid-19 JJ cord-322899-uxvlagt3 14 44 infection infection NN cord-322899-uxvlagt3 14 45 . . . cord-322899-uxvlagt3 15 1 These these DT cord-322899-uxvlagt3 15 2 investigations investigation NNS cord-322899-uxvlagt3 15 3 could could MD cord-322899-uxvlagt3 15 4 be be VB cord-322899-uxvlagt3 15 5 of of IN cord-322899-uxvlagt3 15 6 great great JJ cord-322899-uxvlagt3 15 7 value value NN cord-322899-uxvlagt3 15 8 in in IN cord-322899-uxvlagt3 15 9 dealing deal VBG cord-322899-uxvlagt3 15 10 with with IN cord-322899-uxvlagt3 15 11 future future JJ cord-322899-uxvlagt3 15 12 viral viral JJ cord-322899-uxvlagt3 15 13 epidemics epidemic NNS cord-322899-uxvlagt3 15 14 . . . cord-322899-uxvlagt3 16 1 Coronaviruses Coronaviruses NNP cord-322899-uxvlagt3 16 2 ( ( -LRB- cord-322899-uxvlagt3 16 3 CoV CoV NNP cord-322899-uxvlagt3 16 4 ) ) -RRB- cord-322899-uxvlagt3 16 5 are be VBP cord-322899-uxvlagt3 16 6 a a DT cord-322899-uxvlagt3 16 7 large large JJ cord-322899-uxvlagt3 16 8 group group NN cord-322899-uxvlagt3 16 9 of of IN cord-322899-uxvlagt3 16 10 RNA RNA NNP cord-322899-uxvlagt3 16 11 viruses virus NNS cord-322899-uxvlagt3 16 12 that that WDT cord-322899-uxvlagt3 16 13 primarily primarily RB cord-322899-uxvlagt3 16 14 target target VBP cord-322899-uxvlagt3 16 15 the the DT cord-322899-uxvlagt3 16 16 human human JJ cord-322899-uxvlagt3 16 17 respiratory respiratory JJ cord-322899-uxvlagt3 16 18 system system NN cord-322899-uxvlagt3 16 19 and and CC cord-322899-uxvlagt3 16 20 can can MD cord-322899-uxvlagt3 16 21 lead lead VB cord-322899-uxvlagt3 16 22 to to IN cord-322899-uxvlagt3 16 23 a a DT cord-322899-uxvlagt3 16 24 wide wide JJ cord-322899-uxvlagt3 16 25 range range NN cord-322899-uxvlagt3 16 26 of of IN cord-322899-uxvlagt3 16 27 illnesses illness NNS cord-322899-uxvlagt3 16 28 from from IN cord-322899-uxvlagt3 16 29 the the DT cord-322899-uxvlagt3 16 30 common common JJ cord-322899-uxvlagt3 16 31 cold cold NN cord-322899-uxvlagt3 16 32 to to IN cord-322899-uxvlagt3 16 33 severe severe JJ cord-322899-uxvlagt3 16 34 respiratory respiratory JJ cord-322899-uxvlagt3 16 35 syndromes syndrome NNS cord-322899-uxvlagt3 16 36 . . . cord-322899-uxvlagt3 17 1 In in IN cord-322899-uxvlagt3 17 2 the the DT cord-322899-uxvlagt3 17 3 last last JJ cord-322899-uxvlagt3 17 4 two two CD cord-322899-uxvlagt3 17 5 decades decade NNS cord-322899-uxvlagt3 17 6 , , , cord-322899-uxvlagt3 17 7 outbreaks outbreak NNS cord-322899-uxvlagt3 17 8 of of IN cord-322899-uxvlagt3 17 9 CoV cov NN cord-322899-uxvlagt3 17 10 - - HYPH cord-322899-uxvlagt3 17 11 related relate VBN cord-322899-uxvlagt3 17 12 infections infection NNS cord-322899-uxvlagt3 17 13 , , , cord-322899-uxvlagt3 17 14 including include VBG cord-322899-uxvlagt3 17 15 the the DT cord-322899-uxvlagt3 17 16 severe severe JJ cord-322899-uxvlagt3 17 17 acute acute JJ cord-322899-uxvlagt3 17 18 respiratory respiratory JJ cord-322899-uxvlagt3 17 19 syndrome syndrome NN cord-322899-uxvlagt3 17 20 ( ( -LRB- cord-322899-uxvlagt3 17 21 SARS)-CoV SARS)-CoV NNP cord-322899-uxvlagt3 17 22 and and CC cord-322899-uxvlagt3 17 23 the the DT cord-322899-uxvlagt3 17 24 Middle Middle NNP cord-322899-uxvlagt3 17 25 East East NNP cord-322899-uxvlagt3 17 26 respiratory respiratory JJ cord-322899-uxvlagt3 17 27 syndrome syndrome NN cord-322899-uxvlagt3 17 28 ( ( -LRB- cord-322899-uxvlagt3 17 29 MERS)-CoV MERS)-CoV NNP cord-322899-uxvlagt3 17 30 , , , cord-322899-uxvlagt3 17 31 led lead VBD cord-322899-uxvlagt3 17 32 to to IN cord-322899-uxvlagt3 17 33 great great JJ cord-322899-uxvlagt3 17 34 public public JJ cord-322899-uxvlagt3 17 35 health health NN cord-322899-uxvlagt3 17 36 problems problem NNS cord-322899-uxvlagt3 17 37 and and CC cord-322899-uxvlagt3 17 38 concerns concern NNS cord-322899-uxvlagt3 17 39 . . . cord-322899-uxvlagt3 18 1 [ [ -LRB- cord-322899-uxvlagt3 18 2 1 1 LS cord-322899-uxvlagt3 18 3 ] ] -RRB- cord-322899-uxvlagt3 18 4 A a DT cord-322899-uxvlagt3 18 5 new new JJ cord-322899-uxvlagt3 18 6 coronavirus coronavirus NN cord-322899-uxvlagt3 18 7 termed term VBN cord-322899-uxvlagt3 18 8 COVID-19 COVID-19 NNP cord-322899-uxvlagt3 18 9 is be VBZ cord-322899-uxvlagt3 18 10 currently currently RB cord-322899-uxvlagt3 18 11 associated associate VBN cord-322899-uxvlagt3 18 12 with with IN cord-322899-uxvlagt3 18 13 an an DT cord-322899-uxvlagt3 18 14 increasing increase VBG cord-322899-uxvlagt3 18 15 number number NN cord-322899-uxvlagt3 18 16 and and CC cord-322899-uxvlagt3 18 17 rate rate NN cord-322899-uxvlagt3 18 18 of of IN cord-322899-uxvlagt3 18 19 morbidities morbidity NNS cord-322899-uxvlagt3 18 20 and and CC cord-322899-uxvlagt3 18 21 fatalities fatality NNS cord-322899-uxvlagt3 18 22 . . . cord-322899-uxvlagt3 19 1 The the DT cord-322899-uxvlagt3 19 2 genetic genetic JJ cord-322899-uxvlagt3 19 3 analysis analysis NN cord-322899-uxvlagt3 19 4 of of IN cord-322899-uxvlagt3 19 5 the the DT cord-322899-uxvlagt3 19 6 COVID-19 COVID-19 NNP cord-322899-uxvlagt3 19 7 exhibited exhibit VBD cord-322899-uxvlagt3 19 8 more more JJR cord-322899-uxvlagt3 19 9 than than IN cord-322899-uxvlagt3 19 10 50 50 CD cord-322899-uxvlagt3 19 11 % % NN cord-322899-uxvlagt3 19 12 sequence sequence NN cord-322899-uxvlagt3 19 13 identity identity NN cord-322899-uxvlagt3 19 14 to to IN cord-322899-uxvlagt3 19 15 MERS MERS NNP cord-322899-uxvlagt3 19 16 - - HYPH cord-322899-uxvlagt3 19 17 CoV CoV NNP cord-322899-uxvlagt3 19 18 and and CC cord-322899-uxvlagt3 19 19 80 80 CD cord-322899-uxvlagt3 19 20 % % NN cord-322899-uxvlagt3 19 21 to to IN cord-322899-uxvlagt3 19 22 SARS SARS NNP cord-322899-uxvlagt3 19 23 - - HYPH cord-322899-uxvlagt3 19 24 CoV. CoV. NNP cord-322899-uxvlagt3 19 25 [ [ -LRB- cord-322899-uxvlagt3 19 26 2 2 CD cord-322899-uxvlagt3 19 27 ] ] -RRB- cord-322899-uxvlagt3 20 1 The the DT cord-322899-uxvlagt3 20 2 innate innate JJ cord-322899-uxvlagt3 20 3 immune immune JJ cord-322899-uxvlagt3 20 4 system system NN cord-322899-uxvlagt3 20 5 represents represent VBZ cord-322899-uxvlagt3 20 6 the the DT cord-322899-uxvlagt3 20 7 first first JJ cord-322899-uxvlagt3 20 8 line line NN cord-322899-uxvlagt3 20 9 of of IN cord-322899-uxvlagt3 20 10 defense defense NN cord-322899-uxvlagt3 20 11 against against IN cord-322899-uxvlagt3 20 12 viruses virus NNS cord-322899-uxvlagt3 20 13 , , , cord-322899-uxvlagt3 20 14 which which WDT cord-322899-uxvlagt3 20 15 can can MD cord-322899-uxvlagt3 20 16 inhibit inhibit VB cord-322899-uxvlagt3 20 17 virus virus NN cord-322899-uxvlagt3 20 18 replication replication NN cord-322899-uxvlagt3 20 19 , , , cord-322899-uxvlagt3 20 20 improve improve VB cord-322899-uxvlagt3 20 21 virus virus NN cord-322899-uxvlagt3 20 22 clearance clearance NN cord-322899-uxvlagt3 20 23 , , , cord-322899-uxvlagt3 20 24 promote promote VB cord-322899-uxvlagt3 20 25 tissue tissue NN cord-322899-uxvlagt3 20 26 repair repair NN cord-322899-uxvlagt3 20 27 , , , cord-322899-uxvlagt3 20 28 and and CC cord-322899-uxvlagt3 20 29 activate activate VB cord-322899-uxvlagt3 20 30 a a DT cord-322899-uxvlagt3 20 31 prolonged prolonged JJ cord-322899-uxvlagt3 20 32 adaptive adaptive JJ cord-322899-uxvlagt3 20 33 immune immune JJ cord-322899-uxvlagt3 20 34 response response NN cord-322899-uxvlagt3 20 35 against against IN cord-322899-uxvlagt3 20 36 the the DT cord-322899-uxvlagt3 20 37 viruses virus NNS cord-322899-uxvlagt3 20 38 . . . cord-322899-uxvlagt3 21 1 [ [ -LRB- cord-322899-uxvlagt3 21 2 3 3 CD cord-322899-uxvlagt3 21 3 ] ] -RRB- cord-322899-uxvlagt3 21 4 Viruses virus NNS cord-322899-uxvlagt3 21 5 , , , cord-322899-uxvlagt3 21 6 such such JJ cord-322899-uxvlagt3 21 7 as as IN cord-322899-uxvlagt3 21 8 CoV cov NN cord-322899-uxvlagt3 21 9 , , , cord-322899-uxvlagt3 21 10 could could MD cord-322899-uxvlagt3 21 11 affect affect VB cord-322899-uxvlagt3 21 12 the the DT cord-322899-uxvlagt3 21 13 function function NN cord-322899-uxvlagt3 21 14 of of IN cord-322899-uxvlagt3 21 15 the the DT cord-322899-uxvlagt3 21 16 immune immune JJ cord-322899-uxvlagt3 21 17 system system NN cord-322899-uxvlagt3 21 18 in in IN cord-322899-uxvlagt3 21 19 different different JJ cord-322899-uxvlagt3 21 20 manners manner NNS cord-322899-uxvlagt3 21 21 , , , cord-322899-uxvlagt3 21 22 such such JJ cord-322899-uxvlagt3 21 23 as as IN cord-322899-uxvlagt3 21 24 dysregulation dysregulation NN cord-322899-uxvlagt3 21 25 of of IN cord-322899-uxvlagt3 21 26 the the DT cord-322899-uxvlagt3 21 27 macrophage macrophage NN cord-322899-uxvlagt3 21 28 antiviral antiviral JJ cord-322899-uxvlagt3 21 29 response response NN cord-322899-uxvlagt3 21 30 , , , cord-322899-uxvlagt3 21 31 induction induction NN cord-322899-uxvlagt3 21 32 of of IN cord-322899-uxvlagt3 21 33 excessive excessive JJ cord-322899-uxvlagt3 21 34 cytokine cytokine NN cord-322899-uxvlagt3 21 35 - - HYPH cord-322899-uxvlagt3 21 36 mediated mediate VBN cord-322899-uxvlagt3 21 37 immune immune JJ cord-322899-uxvlagt3 21 38 system system NN cord-322899-uxvlagt3 21 39 responses response NNS cord-322899-uxvlagt3 21 40 , , , cord-322899-uxvlagt3 21 41 and and CC cord-322899-uxvlagt3 21 42 the the DT cord-322899-uxvlagt3 21 43 activation activation NN cord-322899-uxvlagt3 21 44 of of IN cord-322899-uxvlagt3 21 45 complement complement NN cord-322899-uxvlagt3 21 46 and and CC cord-322899-uxvlagt3 21 47 coagulation coagulation NN cord-322899-uxvlagt3 21 48 cascades cascade NNS cord-322899-uxvlagt3 21 49 , , , cord-322899-uxvlagt3 21 50 which which WDT cord-322899-uxvlagt3 21 51 may may MD cord-322899-uxvlagt3 21 52 result result VB cord-322899-uxvlagt3 21 53 in in IN cord-322899-uxvlagt3 21 54 enhanced enhanced JJ cord-322899-uxvlagt3 21 55 infectivity infectivity NN cord-322899-uxvlagt3 21 56 and and CC cord-322899-uxvlagt3 21 57 worse bad JJR cord-322899-uxvlagt3 21 58 outcomes outcome NNS cord-322899-uxvlagt3 21 59 . . . cord-322899-uxvlagt3 22 1 [ [ -LRB- cord-322899-uxvlagt3 22 2 4 4 CD cord-322899-uxvlagt3 22 3 ] ] -RRB- cord-322899-uxvlagt3 23 1 Since since IN cord-322899-uxvlagt3 23 2 there there EX cord-322899-uxvlagt3 23 3 is be VBZ cord-322899-uxvlagt3 23 4 currently currently RB cord-322899-uxvlagt3 23 5 no no DT cord-322899-uxvlagt3 23 6 effective effective JJ cord-322899-uxvlagt3 23 7 drug drug NN cord-322899-uxvlagt3 23 8 or or CC cord-322899-uxvlagt3 23 9 vaccine vaccine NN cord-322899-uxvlagt3 23 10 , , , cord-322899-uxvlagt3 23 11 boosting boost VBG cord-322899-uxvlagt3 23 12 the the DT cord-322899-uxvlagt3 23 13 immune immune JJ cord-322899-uxvlagt3 23 14 system system NN cord-322899-uxvlagt3 23 15 could could MD cord-322899-uxvlagt3 23 16 be be VB cord-322899-uxvlagt3 23 17 a a DT cord-322899-uxvlagt3 23 18 reasonable reasonable JJ cord-322899-uxvlagt3 23 19 option option NN cord-322899-uxvlagt3 23 20 to to TO cord-322899-uxvlagt3 23 21 combat combat VB cord-322899-uxvlagt3 23 22 COVID-19 COVID-19 NNP cord-322899-uxvlagt3 23 23 . . . cord-322899-uxvlagt3 24 1 A a DT cord-322899-uxvlagt3 24 2 functional functional JJ cord-322899-uxvlagt3 24 3 immune immune JJ cord-322899-uxvlagt3 24 4 system system NN cord-322899-uxvlagt3 24 5 is be VBZ cord-322899-uxvlagt3 24 6 a a DT cord-322899-uxvlagt3 24 7 prerequisite prerequisite NN cord-322899-uxvlagt3 24 8 for for IN cord-322899-uxvlagt3 24 9 the the DT cord-322899-uxvlagt3 24 10 host host NN cord-322899-uxvlagt3 24 11 's 's POS cord-322899-uxvlagt3 24 12 ability ability NN cord-322899-uxvlagt3 24 13 to to TO cord-322899-uxvlagt3 24 14 prevent prevent VB cord-322899-uxvlagt3 24 15 or or CC cord-322899-uxvlagt3 24 16 limit limit VB cord-322899-uxvlagt3 24 17 viral viral JJ cord-322899-uxvlagt3 24 18 infections infection NNS cord-322899-uxvlagt3 24 19 . . . cord-322899-uxvlagt3 25 1 It -PRON- PRP cord-322899-uxvlagt3 25 2 is be VBZ cord-322899-uxvlagt3 25 3 well well RB cord-322899-uxvlagt3 25 4 - - HYPH cord-322899-uxvlagt3 25 5 known know VBN cord-322899-uxvlagt3 25 6 that that IN cord-322899-uxvlagt3 25 7 the the DT cord-322899-uxvlagt3 25 8 nutrition nutrition NN cord-322899-uxvlagt3 25 9 of of IN cord-322899-uxvlagt3 25 10 the the DT cord-322899-uxvlagt3 25 11 host host NN cord-322899-uxvlagt3 25 12 may may MD cord-322899-uxvlagt3 25 13 influence influence VB cord-322899-uxvlagt3 25 14 the the DT cord-322899-uxvlagt3 25 15 immune immune JJ cord-322899-uxvlagt3 25 16 system system NN cord-322899-uxvlagt3 25 17 and and CC cord-322899-uxvlagt3 25 18 its -PRON- PRP$ cord-322899-uxvlagt3 25 19 susceptibility susceptibility NN cord-322899-uxvlagt3 25 20 to to IN cord-322899-uxvlagt3 25 21 viral viral JJ cord-322899-uxvlagt3 25 22 infection infection NN cord-322899-uxvlagt3 25 23 . . . cord-322899-uxvlagt3 26 1 Numerous numerous JJ cord-322899-uxvlagt3 26 2 studies study NNS cord-322899-uxvlagt3 26 3 pointed point VBD cord-322899-uxvlagt3 26 4 to to IN cord-322899-uxvlagt3 26 5 the the DT cord-322899-uxvlagt3 26 6 increase increase NN cord-322899-uxvlagt3 26 7 in in IN cord-322899-uxvlagt3 26 8 either either DT cord-322899-uxvlagt3 26 9 susceptibility susceptibility NN cord-322899-uxvlagt3 26 10 to to IN cord-322899-uxvlagt3 26 11 or or CC cord-322899-uxvlagt3 26 12 severity severity NN cord-322899-uxvlagt3 26 13 of of IN cord-322899-uxvlagt3 26 14 various various JJ cord-322899-uxvlagt3 26 15 viral viral JJ cord-322899-uxvlagt3 26 16 infections infection NNS cord-322899-uxvlagt3 26 17 in in IN cord-322899-uxvlagt3 26 18 the the DT cord-322899-uxvlagt3 26 19 nutritionally nutritionally RB cord-322899-uxvlagt3 26 20 deficient deficient JJ cord-322899-uxvlagt3 26 21 subjects subject NNS cord-322899-uxvlagt3 26 22 . . . cord-322899-uxvlagt3 27 1 [ [ -LRB- cord-322899-uxvlagt3 27 2 5 5 CD cord-322899-uxvlagt3 27 3 ] ] -RRB- cord-322899-uxvlagt3 28 1 In in IN cord-322899-uxvlagt3 28 2 addition addition NN cord-322899-uxvlagt3 28 3 to to IN cord-322899-uxvlagt3 28 4 the the DT cord-322899-uxvlagt3 28 5 host host NN cord-322899-uxvlagt3 28 6 's 's POS cord-322899-uxvlagt3 28 7 response response NN cord-322899-uxvlagt3 28 8 , , , cord-322899-uxvlagt3 28 9 various various JJ cord-322899-uxvlagt3 28 10 micronutrients micronutrient NNS cord-322899-uxvlagt3 28 11 can can MD cord-322899-uxvlagt3 28 12 have have VB cord-322899-uxvlagt3 28 13 a a DT cord-322899-uxvlagt3 28 14 significant significant JJ cord-322899-uxvlagt3 28 15 influence influence NN cord-322899-uxvlagt3 28 16 on on IN cord-322899-uxvlagt3 28 17 disease disease NN cord-322899-uxvlagt3 28 18 severity severity NN cord-322899-uxvlagt3 28 19 via via IN cord-322899-uxvlagt3 28 20 the the DT cord-322899-uxvlagt3 28 21 modulation modulation NN cord-322899-uxvlagt3 28 22 of of IN cord-322899-uxvlagt3 28 23 viral viral JJ cord-322899-uxvlagt3 28 24 pathogenesis pathogenesis NN cord-322899-uxvlagt3 28 25 , , , cord-322899-uxvlagt3 28 26 such such JJ cord-322899-uxvlagt3 28 27 as as IN cord-322899-uxvlagt3 28 28 mutations mutation NNS cord-322899-uxvlagt3 28 29 in in IN cord-322899-uxvlagt3 28 30 the the DT cord-322899-uxvlagt3 28 31 viral viral JJ cord-322899-uxvlagt3 28 32 genome genome NN cord-322899-uxvlagt3 28 33 . . . cord-322899-uxvlagt3 29 1 [ [ -LRB- cord-322899-uxvlagt3 29 2 6 6 CD cord-322899-uxvlagt3 29 3 ] ] -RRB- cord-322899-uxvlagt3 30 1 On on IN cord-322899-uxvlagt3 30 2 the the DT cord-322899-uxvlagt3 30 3 contrary contrary NN cord-322899-uxvlagt3 30 4 , , , cord-322899-uxvlagt3 30 5 a a DT cord-322899-uxvlagt3 30 6 viral viral JJ cord-322899-uxvlagt3 30 7 pathogen pathogen NN cord-322899-uxvlagt3 30 8 in in IN cord-322899-uxvlagt3 30 9 the the DT cord-322899-uxvlagt3 30 10 micronutrient micronutrient NN cord-322899-uxvlagt3 30 11 deficient deficient JJ cord-322899-uxvlagt3 30 12 population population NN cord-322899-uxvlagt3 30 13 could could MD cord-322899-uxvlagt3 30 14 replicate replicate VB cord-322899-uxvlagt3 30 15 to to IN cord-322899-uxvlagt3 30 16 a a DT cord-322899-uxvlagt3 30 17 new new JJ cord-322899-uxvlagt3 30 18 , , , cord-322899-uxvlagt3 30 19 more more RBR cord-322899-uxvlagt3 30 20 pathogenic pathogenic JJ cord-322899-uxvlagt3 30 21 strain strain NN cord-322899-uxvlagt3 30 22 . . . cord-322899-uxvlagt3 31 1 [ [ -LRB- cord-322899-uxvlagt3 31 2 7 7 CD cord-322899-uxvlagt3 31 3 ] ] -RRB- cord-322899-uxvlagt3 32 1 The the DT cord-322899-uxvlagt3 32 2 objective objective NN cord-322899-uxvlagt3 32 3 of of IN cord-322899-uxvlagt3 32 4 this this DT cord-322899-uxvlagt3 32 5 review review NN cord-322899-uxvlagt3 32 6 was be VBD cord-322899-uxvlagt3 32 7 to to TO cord-322899-uxvlagt3 32 8 provide provide VB cord-322899-uxvlagt3 32 9 a a DT cord-322899-uxvlagt3 32 10 collection collection NN cord-322899-uxvlagt3 32 11 of of IN cord-322899-uxvlagt3 32 12 evidence evidence NN cord-322899-uxvlagt3 32 13 points point NNS cord-322899-uxvlagt3 32 14 to to IN cord-322899-uxvlagt3 32 15 the the DT cord-322899-uxvlagt3 32 16 key key JJ cord-322899-uxvlagt3 32 17 role role NN cord-322899-uxvlagt3 32 18 of of IN cord-322899-uxvlagt3 32 19 various various JJ cord-322899-uxvlagt3 32 20 micronutrients micronutrient NNS cord-322899-uxvlagt3 32 21 on on IN cord-322899-uxvlagt3 32 22 the the DT cord-322899-uxvlagt3 32 23 interactions interaction NNS cord-322899-uxvlagt3 32 24 between between IN cord-322899-uxvlagt3 32 25 the the DT cord-322899-uxvlagt3 32 26 host host NN cord-322899-uxvlagt3 32 27 immune immune JJ cord-322899-uxvlagt3 32 28 system system NN cord-322899-uxvlagt3 32 29 and and CC cord-322899-uxvlagt3 32 30 viruses virus NNS cord-322899-uxvlagt3 32 31 , , , cord-322899-uxvlagt3 32 32 particularly particularly RB cord-322899-uxvlagt3 32 33 coronaviruses coronaviruse NNS cord-322899-uxvlagt3 32 34 . . . cord-322899-uxvlagt3 33 1 Furthermore furthermore RB cord-322899-uxvlagt3 33 2 , , , cord-322899-uxvlagt3 33 3 we -PRON- PRP cord-322899-uxvlagt3 33 4 describe describe VBP cord-322899-uxvlagt3 33 5 the the DT cord-322899-uxvlagt3 33 6 evidence evidence NN cord-322899-uxvlagt3 33 7 that that WDT cord-322899-uxvlagt3 33 8 may may MD cord-322899-uxvlagt3 33 9 support support VB cord-322899-uxvlagt3 33 10 the the DT cord-322899-uxvlagt3 33 11 contribution contribution NN cord-322899-uxvlagt3 33 12 of of IN cord-322899-uxvlagt3 33 13 micronutrient micronutrient JJ cord-322899-uxvlagt3 33 14 deficiency deficiency NN cord-322899-uxvlagt3 33 15 and and CC cord-322899-uxvlagt3 33 16 immune immune JJ cord-322899-uxvlagt3 33 17 system system NN cord-322899-uxvlagt3 33 18 dysfunction dysfunction NN cord-322899-uxvlagt3 33 19 to to IN cord-322899-uxvlagt3 33 20 the the DT cord-322899-uxvlagt3 33 21 viral viral JJ cord-322899-uxvlagt3 33 22 outbreaks outbreak NNS cord-322899-uxvlagt3 33 23 , , , cord-322899-uxvlagt3 33 24 including include VBG cord-322899-uxvlagt3 33 25 COVID-19 covid-19 VB cord-322899-uxvlagt3 33 26 . . . cord-322899-uxvlagt3 34 1 References reference NNS cord-322899-uxvlagt3 34 2 for for IN cord-322899-uxvlagt3 34 3 this this DT cord-322899-uxvlagt3 34 4 review review NN cord-322899-uxvlagt3 34 5 were be VBD cord-322899-uxvlagt3 34 6 identified identify VBN cord-322899-uxvlagt3 34 7 through through IN cord-322899-uxvlagt3 34 8 searches search NNS cord-322899-uxvlagt3 34 9 of of IN cord-322899-uxvlagt3 34 10 PubMed PubMed NNP cord-322899-uxvlagt3 34 11 for for IN cord-322899-uxvlagt3 34 12 articles article NNS cord-322899-uxvlagt3 34 13 published publish VBN cord-322899-uxvlagt3 34 14 from from IN cord-322899-uxvlagt3 34 15 January January NNP cord-322899-uxvlagt3 34 16 1961 1961 CD cord-322899-uxvlagt3 34 17 to to IN cord-322899-uxvlagt3 34 18 April April NNP cord-322899-uxvlagt3 34 19 2020 2020 CD cord-322899-uxvlagt3 34 20 , , , cord-322899-uxvlagt3 34 21 by by IN cord-322899-uxvlagt3 34 22 use use NN cord-322899-uxvlagt3 34 23 of of IN cord-322899-uxvlagt3 34 24 the the DT cord-322899-uxvlagt3 34 25 terms term NNS cord-322899-uxvlagt3 34 26 " " `` cord-322899-uxvlagt3 34 27 coronavirus coronavirus NN cord-322899-uxvlagt3 34 28 " " '' cord-322899-uxvlagt3 34 29 , , , cord-322899-uxvlagt3 34 30 " " `` cord-322899-uxvlagt3 34 31 immune immune JJ cord-322899-uxvlagt3 34 32 system system NN cord-322899-uxvlagt3 34 33 " " '' cord-322899-uxvlagt3 34 34 , , , cord-322899-uxvlagt3 34 35 " " `` cord-322899-uxvlagt3 34 36 micronutrients micronutrient NNS cord-322899-uxvlagt3 34 37 " " '' cord-322899-uxvlagt3 34 38 , , , cord-322899-uxvlagt3 34 39 " " `` cord-322899-uxvlagt3 34 40 vitamin vitamin NN cord-322899-uxvlagt3 34 41 " " '' cord-322899-uxvlagt3 34 42 , , , cord-322899-uxvlagt3 34 43 and and CC cord-322899-uxvlagt3 34 44 " " `` cord-322899-uxvlagt3 34 45 COVID-19 COVID-19 NNP cord-322899-uxvlagt3 34 46 " " '' cord-322899-uxvlagt3 34 47 . . . cord-322899-uxvlagt3 35 1 Relevant relevant JJ cord-322899-uxvlagt3 35 2 articles article NNS cord-322899-uxvlagt3 35 3 were be VBD cord-322899-uxvlagt3 35 4 identified identify VBN cord-322899-uxvlagt3 35 5 through through IN cord-322899-uxvlagt3 35 6 searches search NNS cord-322899-uxvlagt3 35 7 in in IN cord-322899-uxvlagt3 35 8 Google Google NNP cord-322899-uxvlagt3 35 9 Scholar Scholar NNP cord-322899-uxvlagt3 35 10 and and CC cord-322899-uxvlagt3 35 11 Springer Springer NNP cord-322899-uxvlagt3 35 12 Online Online NNP cord-322899-uxvlagt3 35 13 Archives Archives NNPS cord-322899-uxvlagt3 35 14 Collection Collection NNP cord-322899-uxvlagt3 35 15 . . . cord-322899-uxvlagt3 36 1 Articles article NNS cord-322899-uxvlagt3 36 2 resulting result VBG cord-322899-uxvlagt3 36 3 from from IN cord-322899-uxvlagt3 36 4 these these DT cord-322899-uxvlagt3 36 5 searches search NNS cord-322899-uxvlagt3 36 6 and and CC cord-322899-uxvlagt3 36 7 relevant relevant JJ cord-322899-uxvlagt3 36 8 references reference NNS cord-322899-uxvlagt3 36 9 cited cite VBN cord-322899-uxvlagt3 36 10 in in IN cord-322899-uxvlagt3 36 11 those those DT cord-322899-uxvlagt3 36 12 articles article NNS cord-322899-uxvlagt3 36 13 were be VBD cord-322899-uxvlagt3 36 14 reviewed review VBN cord-322899-uxvlagt3 36 15 . . . cord-322899-uxvlagt3 37 1 Articles article NNS cord-322899-uxvlagt3 37 2 indicate indicate VBP cord-322899-uxvlagt3 37 3 a a DT cord-322899-uxvlagt3 37 4 strong strong JJ cord-322899-uxvlagt3 37 5 link link NN cord-322899-uxvlagt3 37 6 between between IN cord-322899-uxvlagt3 37 7 viral viral JJ cord-322899-uxvlagt3 37 8 infections infection NNS cord-322899-uxvlagt3 37 9 ; ; : cord-322899-uxvlagt3 37 10 particularly particularly RB cord-322899-uxvlagt3 37 11 CoV cov NN cord-322899-uxvlagt3 37 12 infection infection NN cord-322899-uxvlagt3 37 13 , , , cord-322899-uxvlagt3 37 14 with with IN cord-322899-uxvlagt3 37 15 micronutrients micronutrient NNS cord-322899-uxvlagt3 37 16 and and CC cord-322899-uxvlagt3 37 17 the the DT cord-322899-uxvlagt3 37 18 immune immune JJ cord-322899-uxvlagt3 37 19 system system NN cord-322899-uxvlagt3 37 20 were be VBD cord-322899-uxvlagt3 37 21 selected select VBN cord-322899-uxvlagt3 37 22 . . . cord-322899-uxvlagt3 38 1 Articles article NNS cord-322899-uxvlagt3 38 2 published publish VBN cord-322899-uxvlagt3 38 3 in in IN cord-322899-uxvlagt3 38 4 English English NNP cord-322899-uxvlagt3 38 5 and and CC cord-322899-uxvlagt3 38 6 Spanish Spanish NNP cord-322899-uxvlagt3 38 7 were be VBD cord-322899-uxvlagt3 38 8 included include VBN cord-322899-uxvlagt3 38 9 . . . cord-322899-uxvlagt3 39 1 The the DT cord-322899-uxvlagt3 39 2 recruitment recruitment NN cord-322899-uxvlagt3 39 3 of of IN cord-322899-uxvlagt3 39 4 various various JJ cord-322899-uxvlagt3 39 5 immune immune JJ cord-322899-uxvlagt3 39 6 cells cell NNS cord-322899-uxvlagt3 39 7 , , , cord-322899-uxvlagt3 39 8 including include VBG cord-322899-uxvlagt3 39 9 antibody antibody NN cord-322899-uxvlagt3 39 10 - - HYPH cord-322899-uxvlagt3 39 11 secreting secrete VBG cord-322899-uxvlagt3 39 12 cells cell NNS cord-322899-uxvlagt3 39 13 and and CC cord-322899-uxvlagt3 39 14 follicular follicular JJ cord-322899-uxvlagt3 39 15 helper helper NN cord-322899-uxvlagt3 39 16 T t NN cord-322899-uxvlagt3 39 17 cells cell NNS cord-322899-uxvlagt3 39 18 as as RB cord-322899-uxvlagt3 39 19 well well RB cord-322899-uxvlagt3 39 20 as as IN cord-322899-uxvlagt3 39 21 activated activate VBN cord-322899-uxvlagt3 39 22 CD4 CD4 NNP cord-322899-uxvlagt3 39 23 + + CC cord-322899-uxvlagt3 39 24 and and CC cord-322899-uxvlagt3 39 25 CD8 CD8 NNP cord-322899-uxvlagt3 39 26 + + CC cord-322899-uxvlagt3 39 27 T T NNP cord-322899-uxvlagt3 39 28 cells cell NNS cord-322899-uxvlagt3 39 29 , , , cord-322899-uxvlagt3 39 30 along along IN cord-322899-uxvlagt3 39 31 with with IN cord-322899-uxvlagt3 39 32 IgM IgM NNP cord-322899-uxvlagt3 39 33 and and CC cord-322899-uxvlagt3 39 34 IgG IgG NNP cord-322899-uxvlagt3 39 35 COVID-19-binding COVID-19-binding NNP cord-322899-uxvlagt3 39 36 antibodies antibody NNS cord-322899-uxvlagt3 39 37 have have VBP cord-322899-uxvlagt3 39 38 been be VBN cord-322899-uxvlagt3 39 39 reported report VBN cord-322899-uxvlagt3 39 40 in in IN cord-322899-uxvlagt3 39 41 a a DT cord-322899-uxvlagt3 39 42 patient patient NN cord-322899-uxvlagt3 39 43 with with IN cord-322899-uxvlagt3 39 44 non non JJ cord-322899-uxvlagt3 39 45 - - JJ cord-322899-uxvlagt3 39 46 severe severe JJ cord-322899-uxvlagt3 39 47 COVID-19 covid-19 NN cord-322899-uxvlagt3 39 48 . . . cord-322899-uxvlagt3 40 1 [ [ -LRB- cord-322899-uxvlagt3 40 2 8 8 CD cord-322899-uxvlagt3 40 3 ] ] -RRB- cord-322899-uxvlagt3 41 1 In in IN cord-322899-uxvlagt3 41 2 the the DT cord-322899-uxvlagt3 41 3 initiation initiation NN cord-322899-uxvlagt3 41 4 stage stage NN cord-322899-uxvlagt3 41 5 of of IN cord-322899-uxvlagt3 41 6 severe severe JJ cord-322899-uxvlagt3 41 7 COVID-19 COVID-19 NNP cord-322899-uxvlagt3 41 8 , , , cord-322899-uxvlagt3 41 9 increased increase VBN cord-322899-uxvlagt3 41 10 amounts amount NNS cord-322899-uxvlagt3 41 11 of of IN cord-322899-uxvlagt3 41 12 pro pro JJ cord-322899-uxvlagt3 41 13 - - JJ cord-322899-uxvlagt3 41 14 inflammatory inflammatory JJ cord-322899-uxvlagt3 41 15 cytokines cytokine NNS cord-322899-uxvlagt3 41 16 and and CC cord-322899-uxvlagt3 41 17 chemokines chemokine NNS cord-322899-uxvlagt3 41 18 , , , cord-322899-uxvlagt3 41 19 like like IN cord-322899-uxvlagt3 41 20 interleukin-2 interleukin-2 NN cord-322899-uxvlagt3 41 21 ( ( -LRB- cord-322899-uxvlagt3 42 1 IL-2 IL-2 NNP cord-322899-uxvlagt3 42 2 ) ) -RRB- cord-322899-uxvlagt3 42 3 , , , cord-322899-uxvlagt3 42 4 IL-6 IL-6 NNP cord-322899-uxvlagt3 42 5 , , , cord-322899-uxvlagt3 42 6 granulocyte granulocyte NN cord-322899-uxvlagt3 42 7 - - HYPH cord-322899-uxvlagt3 42 8 colony colony NN cord-322899-uxvlagt3 42 9 stimulating stimulate VBG cord-322899-uxvlagt3 42 10 factor factor NN cord-322899-uxvlagt3 42 11 , , , cord-322899-uxvlagt3 42 12 interferon interferon NN cord-322899-uxvlagt3 42 13 ( ( -LRB- cord-322899-uxvlagt3 42 14 IFN IFN NNP cord-322899-uxvlagt3 42 15 ) ) -RRB- cord-322899-uxvlagt3 42 16 γ γ NN cord-322899-uxvlagt3 42 17 - - HYPH cord-322899-uxvlagt3 42 18 induced induce VBN cord-322899-uxvlagt3 42 19 protein protein NN cord-322899-uxvlagt3 42 20 10 10 CD cord-322899-uxvlagt3 42 21 , , , cord-322899-uxvlagt3 42 22 monocyte monocyte NNP cord-322899-uxvlagt3 42 23 chemoattractant chemoattractant NNP cord-322899-uxvlagt3 42 24 protein-1 protein-1 NNP cord-322899-uxvlagt3 42 25 , , , cord-322899-uxvlagt3 42 26 vascular vascular JJ cord-322899-uxvlagt3 42 27 endothelial endothelial JJ cord-322899-uxvlagt3 42 28 growth growth NN cord-322899-uxvlagt3 42 29 factor factor NN cord-322899-uxvlagt3 42 30 , , , cord-322899-uxvlagt3 42 31 macrophage macrophage NN cord-322899-uxvlagt3 42 32 inflammatory inflammatory JJ cord-322899-uxvlagt3 42 33 protein-1α protein-1α NNP cord-322899-uxvlagt3 42 34 , , , cord-322899-uxvlagt3 42 35 and and CC cord-322899-uxvlagt3 42 36 tumor tumor NN cord-322899-uxvlagt3 42 37 necrosis necrosis NN cord-322899-uxvlagt3 42 38 factor factor NN cord-322899-uxvlagt3 42 39 - - HYPH cord-322899-uxvlagt3 42 40 α α NN cord-322899-uxvlagt3 42 41 ( ( -LRB- cord-322899-uxvlagt3 42 42 TNF TNF NNP cord-322899-uxvlagt3 42 43 - - HYPH cord-322899-uxvlagt3 42 44 α α NNP cord-322899-uxvlagt3 42 45 ) ) -RRB- cord-322899-uxvlagt3 42 46 , , , cord-322899-uxvlagt3 42 47 as as RB cord-322899-uxvlagt3 42 48 well well RB cord-322899-uxvlagt3 42 49 as as IN cord-322899-uxvlagt3 42 50 lymphopenia lymphopenia NNP cord-322899-uxvlagt3 42 51 have have VBP cord-322899-uxvlagt3 42 52 been be VBN cord-322899-uxvlagt3 42 53 detected detect VBN cord-322899-uxvlagt3 42 54 in in IN cord-322899-uxvlagt3 42 55 the the DT cord-322899-uxvlagt3 42 56 serum serum NN cord-322899-uxvlagt3 42 57 of of IN cord-322899-uxvlagt3 42 58 some some DT cord-322899-uxvlagt3 42 59 patients patient NNS cord-322899-uxvlagt3 42 60 . . . cord-322899-uxvlagt3 43 1 However however RB cord-322899-uxvlagt3 43 2 , , , cord-322899-uxvlagt3 43 3 infection infection NN cord-322899-uxvlagt3 43 4 with with IN cord-322899-uxvlagt3 43 5 COVID-19 COVID-19 NNP cord-322899-uxvlagt3 43 6 in in IN cord-322899-uxvlagt3 43 7 its -PRON- PRP$ cord-322899-uxvlagt3 43 8 critical critical JJ cord-322899-uxvlagt3 43 9 stage stage NN cord-322899-uxvlagt3 43 10 exacerbates exacerbate VBZ cord-322899-uxvlagt3 43 11 the the DT cord-322899-uxvlagt3 43 12 secretion secretion NN cord-322899-uxvlagt3 43 13 of of IN cord-322899-uxvlagt3 43 14 T T NNP cord-322899-uxvlagt3 43 15 - - HYPH cord-322899-uxvlagt3 43 16 helper-2 helper-2 NN cord-322899-uxvlagt3 44 1 ( ( -LRB- cord-322899-uxvlagt3 44 2 Th2 Th2 NNP cord-322899-uxvlagt3 44 3 ) ) -RRB- cord-322899-uxvlagt3 44 4 cytokines cytokine NNS cord-322899-uxvlagt3 44 5 , , , cord-322899-uxvlagt3 44 6 such such JJ cord-322899-uxvlagt3 44 7 as as IN cord-322899-uxvlagt3 44 8 IL-4 IL-4 NNP cord-322899-uxvlagt3 44 9 , , , cord-322899-uxvlagt3 44 10 IL-1RA il-1ra NN cord-322899-uxvlagt3 44 11 , , , cord-322899-uxvlagt3 44 12 and and CC cord-322899-uxvlagt3 44 13 IL-10 IL-10 NNP cord-322899-uxvlagt3 44 14 , , , cord-322899-uxvlagt3 44 15 which which WDT cord-322899-uxvlagt3 44 16 suppress suppress VBP cord-322899-uxvlagt3 44 17 the the DT cord-322899-uxvlagt3 44 18 inflammatory inflammatory JJ cord-322899-uxvlagt3 44 19 response response NN cord-322899-uxvlagt3 44 20 [ [ -LRB- cord-322899-uxvlagt3 44 21 9 9 CD cord-322899-uxvlagt3 44 22 , , , cord-322899-uxvlagt3 44 23 10 10 CD cord-322899-uxvlagt3 44 24 ] ] -RRB- cord-322899-uxvlagt3 44 25 . . . cord-322899-uxvlagt3 45 1 The the DT cord-322899-uxvlagt3 45 2 preliminary preliminary JJ cord-322899-uxvlagt3 45 3 data datum NNS cord-322899-uxvlagt3 45 4 indicate indicate VBP cord-322899-uxvlagt3 45 5 the the DT cord-322899-uxvlagt3 45 6 ability ability NN cord-322899-uxvlagt3 45 7 of of IN cord-322899-uxvlagt3 45 8 the the DT cord-322899-uxvlagt3 45 9 immune immune JJ cord-322899-uxvlagt3 45 10 system system NN cord-322899-uxvlagt3 45 11 to to TO cord-322899-uxvlagt3 45 12 recognize recognize VB cord-322899-uxvlagt3 45 13 COVID-19 COVID-19 NNP cord-322899-uxvlagt3 45 14 and and CC cord-322899-uxvlagt3 45 15 initiate initiate VB cord-322899-uxvlagt3 45 16 an an DT cord-322899-uxvlagt3 45 17 effective effective JJ cord-322899-uxvlagt3 45 18 immune immune JJ cord-322899-uxvlagt3 45 19 response response NN cord-322899-uxvlagt3 45 20 across across IN cord-322899-uxvlagt3 45 21 different different JJ cord-322899-uxvlagt3 45 22 cell cell NN cord-322899-uxvlagt3 45 23 types type NNS cord-322899-uxvlagt3 45 24 leading lead VBG cord-322899-uxvlagt3 45 25 to to IN cord-322899-uxvlagt3 45 26 successful successful JJ cord-322899-uxvlagt3 45 27 recovery recovery NN cord-322899-uxvlagt3 45 28 from from IN cord-322899-uxvlagt3 45 29 the the DT cord-322899-uxvlagt3 45 30 infection infection NN cord-322899-uxvlagt3 45 31 in in IN cord-322899-uxvlagt3 45 32 cases case NNS cord-322899-uxvlagt3 45 33 with with IN cord-322899-uxvlagt3 45 34 mild mild JJ cord-322899-uxvlagt3 45 35 - - HYPH cord-322899-uxvlagt3 45 36 to to IN cord-322899-uxvlagt3 45 37 - - HYPH cord-322899-uxvlagt3 45 38 moderate moderate JJ cord-322899-uxvlagt3 45 39 symptoms symptom NNS cord-322899-uxvlagt3 45 40 . . . cord-322899-uxvlagt3 46 1 The the DT cord-322899-uxvlagt3 46 2 majority majority NN cord-322899-uxvlagt3 46 3 of of IN cord-322899-uxvlagt3 46 4 subjects subject NNS cord-322899-uxvlagt3 46 5 with with IN cord-322899-uxvlagt3 46 6 Covid-19 Covid-19 NNP cord-322899-uxvlagt3 46 7 only only RB cord-322899-uxvlagt3 46 8 have have VBP cord-322899-uxvlagt3 46 9 mild mild NN cord-322899-uxvlagt3 46 10 - - HYPH cord-322899-uxvlagt3 46 11 to to IN cord-322899-uxvlagt3 46 12 - - HYPH cord-322899-uxvlagt3 46 13 moderate moderate JJ cord-322899-uxvlagt3 46 14 symptoms symptom NNS cord-322899-uxvlagt3 46 15 . . . cord-322899-uxvlagt3 47 1 However however RB cord-322899-uxvlagt3 47 2 , , , cord-322899-uxvlagt3 47 3 the the DT cord-322899-uxvlagt3 47 4 cytokine cytokine NN cord-322899-uxvlagt3 47 5 storm storm NN cord-322899-uxvlagt3 47 6 aggravates aggravate VBZ cord-322899-uxvlagt3 47 7 the the DT cord-322899-uxvlagt3 47 8 infection infection NN cord-322899-uxvlagt3 47 9 severity severity NN cord-322899-uxvlagt3 47 10 and and CC cord-322899-uxvlagt3 47 11 worsens worsen VBZ cord-322899-uxvlagt3 47 12 prognosis prognosis NN cord-322899-uxvlagt3 47 13 . . . cord-322899-uxvlagt3 48 1 [ [ -LRB- cord-322899-uxvlagt3 48 2 9 9 CD cord-322899-uxvlagt3 48 3 , , , cord-322899-uxvlagt3 48 4 10 10 CD cord-322899-uxvlagt3 48 5 ] ] -RRB- cord-322899-uxvlagt3 48 6 Poor poor JJ cord-322899-uxvlagt3 48 7 outcomes outcome NNS cord-322899-uxvlagt3 48 8 with with IN cord-322899-uxvlagt3 48 9 enormously enormously RB cord-322899-uxvlagt3 48 10 high high JJ cord-322899-uxvlagt3 48 11 values value NNS cord-322899-uxvlagt3 48 12 of of IN cord-322899-uxvlagt3 48 13 pro pro JJ cord-322899-uxvlagt3 48 14 - - JJ cord-322899-uxvlagt3 48 15 inflammatory inflammatory JJ cord-322899-uxvlagt3 48 16 cytokines cytokine NNS cord-322899-uxvlagt3 48 17 have have VBP cord-322899-uxvlagt3 48 18 been be VBN cord-322899-uxvlagt3 48 19 also also RB cord-322899-uxvlagt3 48 20 reported report VBN cord-322899-uxvlagt3 48 21 in in IN cord-322899-uxvlagt3 48 22 patients patient NNS cord-322899-uxvlagt3 48 23 infected infect VBN cord-322899-uxvlagt3 48 24 with with IN cord-322899-uxvlagt3 48 25 MERS MERS NNP cord-322899-uxvlagt3 48 26 - - HYPH cord-322899-uxvlagt3 48 27 CoV CoV NNP cord-322899-uxvlagt3 48 28 and and CC cord-322899-uxvlagt3 48 29 SARS SARS NNP cord-322899-uxvlagt3 48 30 - - HYPH cord-322899-uxvlagt3 48 31 CoV. CoV. NNP cord-322899-uxvlagt3 48 32 [ [ -LRB- cord-322899-uxvlagt3 48 33 11 11 CD cord-322899-uxvlagt3 48 34 ] ] -RRB- cord-322899-uxvlagt3 49 1 In in IN cord-322899-uxvlagt3 49 2 addition addition NN cord-322899-uxvlagt3 49 3 , , , cord-322899-uxvlagt3 49 4 it -PRON- PRP cord-322899-uxvlagt3 49 5 has have VBZ cord-322899-uxvlagt3 49 6 been be VBN cord-322899-uxvlagt3 49 7 suggested suggest VBN cord-322899-uxvlagt3 49 8 that that IN cord-322899-uxvlagt3 49 9 a a DT cord-322899-uxvlagt3 49 10 significantly significantly RB cord-322899-uxvlagt3 49 11 elevated elevated JJ cord-322899-uxvlagt3 49 12 amount amount NN cord-322899-uxvlagt3 49 13 of of IN cord-322899-uxvlagt3 49 14 platelets platelet NNS cord-322899-uxvlagt3 49 15 in in IN cord-322899-uxvlagt3 49 16 patients patient NNS cord-322899-uxvlagt3 49 17 with with IN cord-322899-uxvlagt3 49 18 COVID-19 COVID-19 NNP cord-322899-uxvlagt3 49 19 , , , cord-322899-uxvlagt3 49 20 which which WDT cord-322899-uxvlagt3 49 21 is be VBZ cord-322899-uxvlagt3 49 22 associated associate VBN cord-322899-uxvlagt3 49 23 with with IN cord-322899-uxvlagt3 49 24 a a DT cord-322899-uxvlagt3 49 25 longer long RBR cord-322899-uxvlagt3 49 26 average average JJ cord-322899-uxvlagt3 49 27 hospitalization hospitalization NN cord-322899-uxvlagt3 49 28 and and CC cord-322899-uxvlagt3 49 29 poor poor JJ cord-322899-uxvlagt3 49 30 prognosis prognosis NN cord-322899-uxvlagt3 49 31 , , , cord-322899-uxvlagt3 49 32 may may MD cord-322899-uxvlagt3 49 33 be be VB cord-322899-uxvlagt3 49 34 stimulated stimulate VBN cord-322899-uxvlagt3 49 35 by by IN cord-322899-uxvlagt3 49 36 the the DT cord-322899-uxvlagt3 49 37 higher high JJR cord-322899-uxvlagt3 49 38 inflammatory inflammatory JJ cord-322899-uxvlagt3 49 39 cytokine cytokine NN cord-322899-uxvlagt3 49 40 levels level NNS cord-322899-uxvlagt3 49 41 . . . cord-322899-uxvlagt3 50 1 [ [ -LRB- cord-322899-uxvlagt3 50 2 12 12 CD cord-322899-uxvlagt3 50 3 ] ] -RRB- cord-322899-uxvlagt3 50 4 Baseline baseline JJ cord-322899-uxvlagt3 50 5 total total JJ cord-322899-uxvlagt3 50 6 lymphocytes lymphocyte NNS cord-322899-uxvlagt3 50 7 were be VBD cord-322899-uxvlagt3 50 8 significantly significantly RB cord-322899-uxvlagt3 50 9 higher high JJR cord-322899-uxvlagt3 50 10 in in IN cord-322899-uxvlagt3 50 11 survivors survivor NNS cord-322899-uxvlagt3 50 12 than than IN cord-322899-uxvlagt3 50 13 non non NNS cord-322899-uxvlagt3 50 14 - - NNS cord-322899-uxvlagt3 50 15 survivors survivor NNS cord-322899-uxvlagt3 50 16 . . . cord-322899-uxvlagt3 51 1 In in IN cord-322899-uxvlagt3 51 2 survivors survivor NNS cord-322899-uxvlagt3 51 3 , , , cord-322899-uxvlagt3 51 4 lymphopenia lymphopenia NNP cord-322899-uxvlagt3 51 5 improved improve VBN cord-322899-uxvlagt3 51 6 during during IN cord-322899-uxvlagt3 51 7 hospitalization hospitalization NN cord-322899-uxvlagt3 51 8 , , , cord-322899-uxvlagt3 51 9 whereas whereas IN cord-322899-uxvlagt3 51 10 severe severe JJ cord-322899-uxvlagt3 51 11 reduction reduction NN cord-322899-uxvlagt3 51 12 of of IN cord-322899-uxvlagt3 51 13 lymphocytes lymphocyte NNS cord-322899-uxvlagt3 51 14 continued continue VBN cord-322899-uxvlagt3 51 15 to to TO cord-322899-uxvlagt3 51 16 decrease decrease VB cord-322899-uxvlagt3 51 17 until until IN cord-322899-uxvlagt3 51 18 death death NN cord-322899-uxvlagt3 51 19 in in IN cord-322899-uxvlagt3 51 20 non non NNS cord-322899-uxvlagt3 51 21 - - NNS cord-322899-uxvlagt3 51 22 survivors survivor NNS cord-322899-uxvlagt3 51 23 . . . cord-322899-uxvlagt3 52 1 The the DT cord-322899-uxvlagt3 52 2 values value NNS cord-322899-uxvlagt3 52 3 of of IN cord-322899-uxvlagt3 52 4 serum serum NN cord-322899-uxvlagt3 52 5 ferritin ferritin NN cord-322899-uxvlagt3 52 6 and and CC cord-322899-uxvlagt3 52 7 IL-6 IL-6 NNP cord-322899-uxvlagt3 52 8 were be VBD cord-322899-uxvlagt3 52 9 markedly markedly RB cord-322899-uxvlagt3 52 10 greater great JJR cord-322899-uxvlagt3 52 11 in in IN cord-322899-uxvlagt3 52 12 non non NNS cord-322899-uxvlagt3 52 13 - - NNS cord-322899-uxvlagt3 52 14 survivors survivor NNS cord-322899-uxvlagt3 52 15 than than IN cord-322899-uxvlagt3 52 16 survivors survivor NNS cord-322899-uxvlagt3 52 17 . . . cord-322899-uxvlagt3 53 1 [ [ -LRB- cord-322899-uxvlagt3 53 2 13 13 CD cord-322899-uxvlagt3 53 3 ] ] -RRB- cord-322899-uxvlagt3 54 1 Due due IN cord-322899-uxvlagt3 54 2 to to IN cord-322899-uxvlagt3 54 3 the the DT cord-322899-uxvlagt3 54 4 supporting support VBG cord-322899-uxvlagt3 54 5 role role NN cord-322899-uxvlagt3 54 6 of of IN cord-322899-uxvlagt3 54 7 micronutrients micronutrient NNS cord-322899-uxvlagt3 54 8 on on IN cord-322899-uxvlagt3 54 9 the the DT cord-322899-uxvlagt3 54 10 host host NN cord-322899-uxvlagt3 54 11 immune immune JJ cord-322899-uxvlagt3 54 12 responses response NNS cord-322899-uxvlagt3 54 13 to to IN cord-322899-uxvlagt3 54 14 viral viral JJ cord-322899-uxvlagt3 54 15 infections infection NNS cord-322899-uxvlagt3 54 16 _SP cord-322899-uxvlagt3 55 1 ( ( -LRB- cord-322899-uxvlagt3 55 2 table table NN cord-322899-uxvlagt3 55 3 1 1 CD cord-322899-uxvlagt3 55 4 ) ) -RRB- cord-322899-uxvlagt3 56 1 , , , cord-322899-uxvlagt3 56 2 it -PRON- PRP cord-322899-uxvlagt3 56 3 is be VBZ cord-322899-uxvlagt3 56 4 not not RB cord-322899-uxvlagt3 56 5 surprising surprising JJ cord-322899-uxvlagt3 56 6 if if IN cord-322899-uxvlagt3 56 7 micronutrient micronutrient JJ cord-322899-uxvlagt3 56 8 deficiency deficiency NN cord-322899-uxvlagt3 56 9 would would MD cord-322899-uxvlagt3 56 10 be be VB cord-322899-uxvlagt3 56 11 associated associate VBN cord-322899-uxvlagt3 56 12 with with IN cord-322899-uxvlagt3 56 13 a a DT cord-322899-uxvlagt3 56 14 weakened weaken VBN cord-322899-uxvlagt3 56 15 immune immune JJ cord-322899-uxvlagt3 56 16 system system NN cord-322899-uxvlagt3 56 17 and and CC cord-322899-uxvlagt3 56 18 a a DT cord-322899-uxvlagt3 56 19 higher high JJR cord-322899-uxvlagt3 56 20 risk risk NN cord-322899-uxvlagt3 56 21 for for IN cord-322899-uxvlagt3 56 22 the the DT cord-322899-uxvlagt3 56 23 occurrence occurrence NN cord-322899-uxvlagt3 56 24 and and CC cord-322899-uxvlagt3 56 25 severity severity NN cord-322899-uxvlagt3 56 26 of of IN cord-322899-uxvlagt3 56 27 viral viral JJ cord-322899-uxvlagt3 56 28 infections infection NNS cord-322899-uxvlagt3 56 29 . . . cord-322899-uxvlagt3 57 1 Zinc zinc NN cord-322899-uxvlagt3 57 2 homeostasis homeostasis NN cord-322899-uxvlagt3 57 3 is be VBZ cord-322899-uxvlagt3 57 4 essential essential JJ cord-322899-uxvlagt3 57 5 for for IN cord-322899-uxvlagt3 57 6 sustaining sustain VBG cord-322899-uxvlagt3 57 7 proper proper JJ cord-322899-uxvlagt3 57 8 immune immune JJ cord-322899-uxvlagt3 57 9 function function NN cord-322899-uxvlagt3 57 10 . . . cord-322899-uxvlagt3 58 1 [ [ -LRB- cord-322899-uxvlagt3 58 2 14 14 CD cord-322899-uxvlagt3 58 3 ] ] -RRB- cord-322899-uxvlagt3 58 4 Zinc zinc NN cord-322899-uxvlagt3 58 5 plays play VBZ cord-322899-uxvlagt3 58 6 an an DT cord-322899-uxvlagt3 58 7 important important JJ cord-322899-uxvlagt3 58 8 role role NN cord-322899-uxvlagt3 58 9 in in IN cord-322899-uxvlagt3 58 10 host host NN cord-322899-uxvlagt3 58 11 - - HYPH cord-322899-uxvlagt3 58 12 virus virus NN cord-322899-uxvlagt3 58 13 interactions interaction NNS cord-322899-uxvlagt3 58 14 due due JJ cord-322899-uxvlagt3 58 15 to to IN cord-322899-uxvlagt3 58 16 its -PRON- PRP$ cord-322899-uxvlagt3 58 17 effect effect NN cord-322899-uxvlagt3 58 18 on on IN cord-322899-uxvlagt3 58 19 nucleic nucleic JJ cord-322899-uxvlagt3 58 20 acid acid NN cord-322899-uxvlagt3 58 21 synthesis synthesis NN cord-322899-uxvlagt3 58 22 and and CC cord-322899-uxvlagt3 58 23 repair repair NN cord-322899-uxvlagt3 58 24 , , , cord-322899-uxvlagt3 58 25 apoptosis apoptosis NN cord-322899-uxvlagt3 58 26 , , , cord-322899-uxvlagt3 58 27 inflammation inflammation NN cord-322899-uxvlagt3 58 28 , , , cord-322899-uxvlagt3 58 29 and and CC cord-322899-uxvlagt3 58 30 redox redox NN cord-322899-uxvlagt3 58 31 homeostasis homeostasis NN cord-322899-uxvlagt3 58 32 . . . cord-322899-uxvlagt3 59 1 [ [ -LRB- cord-322899-uxvlagt3 59 2 15 15 CD cord-322899-uxvlagt3 59 3 ] ] -RRB- cord-322899-uxvlagt3 59 4 Zinc zinc NN cord-322899-uxvlagt3 59 5 baseline baseline JJ cord-322899-uxvlagt3 59 6 level level NN cord-322899-uxvlagt3 59 7 is be VBZ cord-322899-uxvlagt3 59 8 a a DT cord-322899-uxvlagt3 59 9 crucial crucial JJ cord-322899-uxvlagt3 59 10 factor factor NN cord-322899-uxvlagt3 59 11 that that WDT cord-322899-uxvlagt3 59 12 can can MD cord-322899-uxvlagt3 59 13 affect affect VB cord-322899-uxvlagt3 59 14 antiviral antiviral JJ cord-322899-uxvlagt3 59 15 immunity immunity NN cord-322899-uxvlagt3 59 16 , , , cord-322899-uxvlagt3 59 17 especially especially RB cord-322899-uxvlagt3 59 18 in in IN cord-322899-uxvlagt3 59 19 zinc zinc NN cord-322899-uxvlagt3 59 20 - - HYPH cord-322899-uxvlagt3 59 21 deficient deficient JJ cord-322899-uxvlagt3 59 22 populations population NNS cord-322899-uxvlagt3 59 23 . . . cord-322899-uxvlagt3 60 1 [ [ -LRB- cord-322899-uxvlagt3 60 2 16 16 CD cord-322899-uxvlagt3 60 3 ] ] -RRB- cord-322899-uxvlagt3 60 4 Zinc zinc NN cord-322899-uxvlagt3 60 5 deficiency deficiency NN cord-322899-uxvlagt3 60 6 is be VBZ cord-322899-uxvlagt3 60 7 associated associate VBN cord-322899-uxvlagt3 60 8 with with IN cord-322899-uxvlagt3 60 9 impaired impaired JJ cord-322899-uxvlagt3 60 10 immune immune JJ cord-322899-uxvlagt3 60 11 responses response NNS cord-322899-uxvlagt3 60 12 and and CC cord-322899-uxvlagt3 60 13 leads lead VBZ cord-322899-uxvlagt3 60 14 to to IN cord-322899-uxvlagt3 60 15 a a DT cord-322899-uxvlagt3 60 16 higher high JJR cord-322899-uxvlagt3 60 17 risk risk NN cord-322899-uxvlagt3 60 18 of of IN cord-322899-uxvlagt3 60 19 respiratory respiratory JJ cord-322899-uxvlagt3 60 20 viral viral JJ cord-322899-uxvlagt3 60 21 infections infection NNS cord-322899-uxvlagt3 60 22 , , , cord-322899-uxvlagt3 60 23 particularly particularly RB cord-322899-uxvlagt3 60 24 in in IN cord-322899-uxvlagt3 60 25 elderly elderly JJ cord-322899-uxvlagt3 60 26 subjects subject NNS cord-322899-uxvlagt3 60 27 . . . cord-322899-uxvlagt3 61 1 [ [ -LRB- cord-322899-uxvlagt3 61 2 17 17 CD cord-322899-uxvlagt3 61 3 ] ] -RRB- cord-322899-uxvlagt3 61 4 Zinc Zinc NNP cord-322899-uxvlagt3 61 5 is be VBZ cord-322899-uxvlagt3 61 6 involved involve VBN cord-322899-uxvlagt3 61 7 in in IN cord-322899-uxvlagt3 61 8 the the DT cord-322899-uxvlagt3 61 9 modulation modulation NN cord-322899-uxvlagt3 61 10 of of IN cord-322899-uxvlagt3 61 11 the the DT cord-322899-uxvlagt3 61 12 pro pro JJ cord-322899-uxvlagt3 61 13 - - JJ cord-322899-uxvlagt3 61 14 inflammatory inflammatory JJ cord-322899-uxvlagt3 61 15 response response NN cord-322899-uxvlagt3 61 16 by by IN cord-322899-uxvlagt3 61 17 targeting target VBG cord-322899-uxvlagt3 61 18 nuclear nuclear JJ cord-322899-uxvlagt3 61 19 factor factor NN cord-322899-uxvlagt3 61 20 Kappa Kappa NNP cord-322899-uxvlagt3 61 21 B B NNP cord-322899-uxvlagt3 61 22 ( ( -LRB- cord-322899-uxvlagt3 61 23 NF nf NN cord-322899-uxvlagt3 61 24 - - HYPH cord-322899-uxvlagt3 61 25 κB κB NNP cord-322899-uxvlagt3 61 26 ) ) -RRB- cord-322899-uxvlagt3 61 27 . . . cord-322899-uxvlagt3 62 1 Zinc zinc NN cord-322899-uxvlagt3 62 2 deficiency deficiency NN cord-322899-uxvlagt3 62 3 enhances enhance VBZ cord-322899-uxvlagt3 62 4 the the DT cord-322899-uxvlagt3 62 5 production production NN cord-322899-uxvlagt3 62 6 of of IN cord-322899-uxvlagt3 62 7 pro pro JJ cord-322899-uxvlagt3 62 8 - - JJ cord-322899-uxvlagt3 62 9 inflammatory inflammatory JJ cord-322899-uxvlagt3 62 10 cytokines cytokine NNS cord-322899-uxvlagt3 62 11 , , , cord-322899-uxvlagt3 62 12 such such JJ cord-322899-uxvlagt3 62 13 as as IN cord-322899-uxvlagt3 62 14 IL-1β IL-1β NNP cord-322899-uxvlagt3 62 15 , , , cord-322899-uxvlagt3 62 16 IL-6 IL-6 NNP cord-322899-uxvlagt3 62 17 , , , cord-322899-uxvlagt3 62 18 and and CC cord-322899-uxvlagt3 62 19 TNF TNF NNP cord-322899-uxvlagt3 62 20 - - HYPH cord-322899-uxvlagt3 62 21 α α NNP cord-322899-uxvlagt3 62 22 , , , cord-322899-uxvlagt3 62 23 and and CC cord-322899-uxvlagt3 62 24 reduces reduce VBZ cord-322899-uxvlagt3 62 25 the the DT cord-322899-uxvlagt3 62 26 lytic lytic JJ cord-322899-uxvlagt3 62 27 activity activity NN cord-322899-uxvlagt3 62 28 of of IN cord-322899-uxvlagt3 62 29 natural natural JJ cord-322899-uxvlagt3 62 30 killer killer NN cord-322899-uxvlagt3 62 31 ( ( -LRB- cord-322899-uxvlagt3 62 32 NK NK NNP cord-322899-uxvlagt3 62 33 ) ) -RRB- cord-322899-uxvlagt3 62 34 cells cell NNS cord-322899-uxvlagt3 62 35 . . . cord-322899-uxvlagt3 63 1 Furthermore furthermore RB cord-322899-uxvlagt3 63 2 , , , cord-322899-uxvlagt3 63 3 zinc zinc NN cord-322899-uxvlagt3 63 4 deficiency deficiency NN cord-322899-uxvlagt3 63 5 leads lead VBZ cord-322899-uxvlagt3 63 6 to to IN cord-322899-uxvlagt3 63 7 a a DT cord-322899-uxvlagt3 63 8 decrease decrease NN cord-322899-uxvlagt3 63 9 in in IN cord-322899-uxvlagt3 63 10 antibody antibody NN cord-322899-uxvlagt3 63 11 production production NN cord-322899-uxvlagt3 63 12 via via IN cord-322899-uxvlagt3 63 13 the the DT cord-322899-uxvlagt3 63 14 alteration alteration NN cord-322899-uxvlagt3 63 15 of of IN cord-322899-uxvlagt3 63 16 the the DT cord-322899-uxvlagt3 63 17 function function NN cord-322899-uxvlagt3 63 18 and and CC cord-322899-uxvlagt3 63 19 number number NN cord-322899-uxvlagt3 63 20 of of IN cord-322899-uxvlagt3 63 21 various various JJ cord-322899-uxvlagt3 63 22 immune immune JJ cord-322899-uxvlagt3 63 23 cells cell NNS cord-322899-uxvlagt3 63 24 . . . cord-322899-uxvlagt3 64 1 [ [ -LRB- cord-322899-uxvlagt3 64 2 14 14 CD cord-322899-uxvlagt3 64 3 ] ] -RRB- cord-322899-uxvlagt3 65 1 The the DT cord-322899-uxvlagt3 65 2 zinc zinc NN cord-322899-uxvlagt3 65 3 - - HYPH cord-322899-uxvlagt3 65 4 finger finger NN cord-322899-uxvlagt3 65 5 domain domain NN cord-322899-uxvlagt3 65 6 is be VBZ cord-322899-uxvlagt3 65 7 found find VBN cord-322899-uxvlagt3 65 8 in in IN cord-322899-uxvlagt3 65 9 various various JJ cord-322899-uxvlagt3 65 10 proteins protein NNS cord-322899-uxvlagt3 65 11 encoded encode VBN cord-322899-uxvlagt3 65 12 by by IN cord-322899-uxvlagt3 65 13 the the DT cord-322899-uxvlagt3 65 14 genome genome NN cord-322899-uxvlagt3 65 15 of of IN cord-322899-uxvlagt3 65 16 different different JJ cord-322899-uxvlagt3 65 17 CoV cov NN cord-322899-uxvlagt3 65 18 , , , cord-322899-uxvlagt3 65 19 such such JJ cord-322899-uxvlagt3 65 20 as as IN cord-322899-uxvlagt3 65 21 SARS SARS NNP cord-322899-uxvlagt3 65 22 - - HYPH cord-322899-uxvlagt3 65 23 CoV CoV NNP cord-322899-uxvlagt3 65 24 [ [ -LRB- cord-322899-uxvlagt3 65 25 18 18 CD cord-322899-uxvlagt3 65 26 ] ] -RRB- cord-322899-uxvlagt3 65 27 , , , cord-322899-uxvlagt3 65 28 and and CC cord-322899-uxvlagt3 65 29 plays play VBZ cord-322899-uxvlagt3 65 30 a a DT cord-322899-uxvlagt3 65 31 key key JJ cord-322899-uxvlagt3 65 32 role role NN cord-322899-uxvlagt3 65 33 in in IN cord-322899-uxvlagt3 65 34 viral viral JJ cord-322899-uxvlagt3 65 35 replication replication NN cord-322899-uxvlagt3 65 36 and and CC cord-322899-uxvlagt3 65 37 transcription transcription NN cord-322899-uxvlagt3 65 38 . . . cord-322899-uxvlagt3 66 1 [ [ -LRB- cord-322899-uxvlagt3 66 2 19 19 CD cord-322899-uxvlagt3 66 3 ] ] -RRB- cord-322899-uxvlagt3 67 1 A a DT cord-322899-uxvlagt3 67 2 specific specific JJ cord-322899-uxvlagt3 67 3 mutation mutation NN cord-322899-uxvlagt3 67 4 within within IN cord-322899-uxvlagt3 67 5 the the DT cord-322899-uxvlagt3 67 6 zinc zinc NN cord-322899-uxvlagt3 67 7 - - HYPH cord-322899-uxvlagt3 67 8 finger finger NN cord-322899-uxvlagt3 67 9 domain domain NN cord-322899-uxvlagt3 67 10 of of IN cord-322899-uxvlagt3 67 11 CoV cov NN cord-322899-uxvlagt3 67 12 caused cause VBD cord-322899-uxvlagt3 67 13 reduced reduce VBN cord-322899-uxvlagt3 67 14 antiviral antiviral JJ cord-322899-uxvlagt3 67 15 response response NN cord-322899-uxvlagt3 67 16 . . . cord-322899-uxvlagt3 68 1 [ [ -LRB- cord-322899-uxvlagt3 68 2 20 20 CD cord-322899-uxvlagt3 68 3 ] ] -RRB- cord-322899-uxvlagt3 68 4 Disruption disruption NN cord-322899-uxvlagt3 68 5 of of IN cord-322899-uxvlagt3 68 6 the the DT cord-322899-uxvlagt3 68 7 zinc zinc NN cord-322899-uxvlagt3 68 8 - - HYPH cord-322899-uxvlagt3 68 9 binding bind VBG cord-322899-uxvlagt3 68 10 function function NN cord-322899-uxvlagt3 68 11 of of IN cord-322899-uxvlagt3 68 12 CoV-229E CoV-229E NNP cord-322899-uxvlagt3 68 13 nonstructural nonstructural JJ cord-322899-uxvlagt3 68 14 protein-13 protein-13 NNS cord-322899-uxvlagt3 68 15 ( ( -LRB- cord-322899-uxvlagt3 68 16 nsp13 nsp13 NNP cord-322899-uxvlagt3 68 17 ) ) -RRB- cord-322899-uxvlagt3 68 18 or or CC cord-322899-uxvlagt3 68 19 deletion deletion NN cord-322899-uxvlagt3 68 20 of of IN cord-322899-uxvlagt3 68 21 the the DT cord-322899-uxvlagt3 68 22 entire entire JJ cord-322899-uxvlagt3 68 23 zinc zinc NN cord-322899-uxvlagt3 68 24 - - HYPH cord-322899-uxvlagt3 68 25 binding bind VBG cord-322899-uxvlagt3 68 26 domain domain NN cord-322899-uxvlagt3 68 27 affects affect VBZ cord-322899-uxvlagt3 68 28 both both DT cord-322899-uxvlagt3 68 29 transcription transcription NN cord-322899-uxvlagt3 68 30 and and CC cord-322899-uxvlagt3 68 31 replication replication NN cord-322899-uxvlagt3 68 32 of of IN cord-322899-uxvlagt3 68 33 CoV. CoV. NNP cord-322899-uxvlagt3 68 34 [ [ -LRB- cord-322899-uxvlagt3 68 35 21 21 CD cord-322899-uxvlagt3 68 36 ] ] -RRB- cord-322899-uxvlagt3 69 1 Furthermore furthermore RB cord-322899-uxvlagt3 69 2 , , , cord-322899-uxvlagt3 69 3 it -PRON- PRP cord-322899-uxvlagt3 69 4 has have VBZ cord-322899-uxvlagt3 69 5 been be VBN cord-322899-uxvlagt3 69 6 shown show VBN cord-322899-uxvlagt3 69 7 that that IN cord-322899-uxvlagt3 69 8 the the DT cord-322899-uxvlagt3 69 9 zinc zinc NN cord-322899-uxvlagt3 69 10 - - HYPH cord-322899-uxvlagt3 69 11 binding bind VBG cord-322899-uxvlagt3 69 12 domain domain NN cord-322899-uxvlagt3 69 13 may may MD cord-322899-uxvlagt3 69 14 start start VB cord-322899-uxvlagt3 69 15 to to TO cord-322899-uxvlagt3 69 16 unfold unfold VB cord-322899-uxvlagt3 69 17 during during IN cord-322899-uxvlagt3 69 18 the the DT cord-322899-uxvlagt3 69 19 first first JJ cord-322899-uxvlagt3 69 20 transition transition NN cord-322899-uxvlagt3 69 21 of of IN cord-322899-uxvlagt3 69 22 SARS SARS NNP cord-322899-uxvlagt3 69 23 - - HYPH cord-322899-uxvlagt3 69 24 CoV CoV NNP cord-322899-uxvlagt3 69 25 and and CC cord-322899-uxvlagt3 69 26 lead lead VB cord-322899-uxvlagt3 69 27 to to IN cord-322899-uxvlagt3 69 28 a a DT cord-322899-uxvlagt3 69 29 reduction reduction NN cord-322899-uxvlagt3 69 30 in in IN cord-322899-uxvlagt3 69 31 pathogen pathogen NN cord-322899-uxvlagt3 69 32 virulence virulence NN cord-322899-uxvlagt3 69 33 . . . cord-322899-uxvlagt3 69 34 _SP cord-322899-uxvlagt3 70 1 Selenium selenium NN cord-322899-uxvlagt3 70 2 deficiency deficiency NN cord-322899-uxvlagt3 70 3 not not RB cord-322899-uxvlagt3 70 4 only only RB cord-322899-uxvlagt3 70 5 weakens weaken VBZ cord-322899-uxvlagt3 70 6 the the DT cord-322899-uxvlagt3 70 7 host host NN cord-322899-uxvlagt3 70 8 immune immune JJ cord-322899-uxvlagt3 70 9 system system NN cord-322899-uxvlagt3 70 10 against against IN cord-322899-uxvlagt3 70 11 viral viral JJ cord-322899-uxvlagt3 70 12 infections infection NNS cord-322899-uxvlagt3 70 13 but but CC cord-322899-uxvlagt3 70 14 also also RB cord-322899-uxvlagt3 70 15 leads lead VBZ cord-322899-uxvlagt3 70 16 to to IN cord-322899-uxvlagt3 70 17 viral viral JJ cord-322899-uxvlagt3 70 18 genome genome NN cord-322899-uxvlagt3 70 19 mutations mutation NNS cord-322899-uxvlagt3 70 20 from from IN cord-322899-uxvlagt3 70 21 benign benign JJ cord-322899-uxvlagt3 70 22 variants variant NNS cord-322899-uxvlagt3 70 23 to to IN cord-322899-uxvlagt3 70 24 highly highly RB cord-322899-uxvlagt3 70 25 pathogenic pathogenic JJ cord-322899-uxvlagt3 70 26 viruses virus NNS cord-322899-uxvlagt3 70 27 . . . cord-322899-uxvlagt3 71 1 [ [ -LRB- cord-322899-uxvlagt3 71 2 4 4 CD cord-322899-uxvlagt3 71 3 ] ] -RRB- cord-322899-uxvlagt3 71 4 Inadequate inadequate JJ cord-322899-uxvlagt3 71 5 antioxidant antioxidant JJ cord-322899-uxvlagt3 71 6 protection protection NN cord-322899-uxvlagt3 71 7 against against IN cord-322899-uxvlagt3 71 8 various various JJ cord-322899-uxvlagt3 71 9 mutating mutate VBG cord-322899-uxvlagt3 71 10 RNA RNA NNP cord-322899-uxvlagt3 71 11 viruses virus NNS cord-322899-uxvlagt3 71 12 , , , cord-322899-uxvlagt3 71 13 including include VBG cord-322899-uxvlagt3 71 14 SARS SARS NNP cord-322899-uxvlagt3 71 15 - - HYPH cord-322899-uxvlagt3 71 16 CoV CoV NNP cord-322899-uxvlagt3 71 17 , , , cord-322899-uxvlagt3 71 18 has have VBZ cord-322899-uxvlagt3 71 19 been be VBN cord-322899-uxvlagt3 71 20 observed observe VBN cord-322899-uxvlagt3 71 21 in in IN cord-322899-uxvlagt3 71 22 subjects subject NNS cord-322899-uxvlagt3 71 23 with with IN cord-322899-uxvlagt3 71 24 blood blood NN cord-322899-uxvlagt3 71 25 selenium selenium NN cord-322899-uxvlagt3 71 26 concentrations concentration NNS cord-322899-uxvlagt3 71 27 of of IN cord-322899-uxvlagt3 71 28 less less JJR cord-322899-uxvlagt3 71 29 than than IN cord-322899-uxvlagt3 71 30 1 1 CD cord-322899-uxvlagt3 71 31 μM μM NNP cord-322899-uxvlagt3 71 32 / / SYM cord-322899-uxvlagt3 71 33 L. L. NNP cord-322899-uxvlagt3 71 34 _SP cord-322899-uxvlagt3 71 35 Iodide Iodide NNP cord-322899-uxvlagt3 71 36 modulates modulate VBZ cord-322899-uxvlagt3 71 37 the the DT cord-322899-uxvlagt3 71 38 transcriptional transcriptional JJ cord-322899-uxvlagt3 71 39 immune immune JJ cord-322899-uxvlagt3 71 40 signature signature NN cord-322899-uxvlagt3 71 41 of of IN cord-322899-uxvlagt3 71 42 human human JJ cord-322899-uxvlagt3 71 43 peripheral peripheral JJ cord-322899-uxvlagt3 71 44 blood blood NN cord-322899-uxvlagt3 71 45 immune immune JJ cord-322899-uxvlagt3 71 46 cells cell NNS cord-322899-uxvlagt3 71 47 and and CC cord-322899-uxvlagt3 71 48 induces induce VBZ cord-322899-uxvlagt3 71 49 greater great JJR cord-322899-uxvlagt3 71 50 cytokine cytokine NN cord-322899-uxvlagt3 71 51 and and CC cord-322899-uxvlagt3 71 52 chemokine chemokine NN cord-322899-uxvlagt3 71 53 secretion secretion NN cord-322899-uxvlagt3 71 54 , , , cord-322899-uxvlagt3 71 55 such such JJ cord-322899-uxvlagt3 71 56 as as IN cord-322899-uxvlagt3 71 57 IL-6 IL-6 NNP cord-322899-uxvlagt3 71 58 , , , cord-322899-uxvlagt3 71 59 IL-8 IL-8 NNP cord-322899-uxvlagt3 71 60 , , , cord-322899-uxvlagt3 71 61 and and CC cord-322899-uxvlagt3 71 62 IL-10 IL-10 NNP cord-322899-uxvlagt3 71 63 . . . cord-322899-uxvlagt3 72 1 [ [ -LRB- cord-322899-uxvlagt3 72 2 36 36 CD cord-322899-uxvlagt3 72 3 ] ] -RRB- cord-322899-uxvlagt3 72 4 Iodide iodide NN cord-322899-uxvlagt3 72 5 is be VBZ cord-322899-uxvlagt3 72 6 found find VBN cord-322899-uxvlagt3 72 7 in in IN cord-322899-uxvlagt3 72 8 the the DT cord-322899-uxvlagt3 72 9 salivary salivary NN cord-322899-uxvlagt3 72 10 glands gland NNS cord-322899-uxvlagt3 72 11 , , , cord-322899-uxvlagt3 72 12 nasal nasal NN cord-322899-uxvlagt3 72 13 mucosa mucosa NN cord-322899-uxvlagt3 72 14 , , , cord-322899-uxvlagt3 72 15 and and CC cord-322899-uxvlagt3 72 16 lung lung NN cord-322899-uxvlagt3 72 17 secretions secretion NNS cord-322899-uxvlagt3 72 18 . . . cord-322899-uxvlagt3 73 1 [ [ -LRB- cord-322899-uxvlagt3 73 2 37 37 CD cord-322899-uxvlagt3 73 3 ] ] -RRB- cord-322899-uxvlagt3 74 1 The the DT cord-322899-uxvlagt3 74 2 sodium sodium NN cord-322899-uxvlagt3 74 3 - - HYPH cord-322899-uxvlagt3 74 4 iodine iodine NN cord-322899-uxvlagt3 74 5 symporter symporter NN cord-322899-uxvlagt3 74 6 , , , cord-322899-uxvlagt3 74 7 a a DT cord-322899-uxvlagt3 74 8 plasma plasma NN cord-322899-uxvlagt3 74 9 membrane membrane NN cord-322899-uxvlagt3 74 10 glycoprotein glycoprotein NN cord-322899-uxvlagt3 74 11 that that WDT cord-322899-uxvlagt3 74 12 mediates mediate VBZ cord-322899-uxvlagt3 74 13 active active JJ cord-322899-uxvlagt3 74 14 Iodide Iodide NNP cord-322899-uxvlagt3 74 15 transport transport NN cord-322899-uxvlagt3 74 16 in in IN cord-322899-uxvlagt3 74 17 different different JJ cord-322899-uxvlagt3 74 18 tissues tissue NNS cord-322899-uxvlagt3 74 19 , , , cord-322899-uxvlagt3 74 20 contributes contribute VBZ cord-322899-uxvlagt3 74 21 to to IN cord-322899-uxvlagt3 74 22 the the DT cord-322899-uxvlagt3 74 23 oxidation oxidation NN cord-322899-uxvlagt3 74 24 of of IN cord-322899-uxvlagt3 74 25 iodide iodide NN cord-322899-uxvlagt3 74 26 in in IN cord-322899-uxvlagt3 74 27 the the DT cord-322899-uxvlagt3 74 28 lungs lung NNS cord-322899-uxvlagt3 74 29 , , , cord-322899-uxvlagt3 74 30 which which WDT cord-322899-uxvlagt3 74 31 improves improve VBZ cord-322899-uxvlagt3 74 32 the the DT cord-322899-uxvlagt3 74 33 antiviral antiviral JJ cord-322899-uxvlagt3 74 34 respiratory respiratory JJ cord-322899-uxvlagt3 74 35 defense defense NN cord-322899-uxvlagt3 74 36 system system NN cord-322899-uxvlagt3 74 37 . . . cord-322899-uxvlagt3 75 1 [ [ -LRB- cord-322899-uxvlagt3 75 2 38 38 CD cord-322899-uxvlagt3 75 3 ] ] -RRB- cord-322899-uxvlagt3 76 1 The the DT cord-322899-uxvlagt3 76 2 oral oral JJ cord-322899-uxvlagt3 76 3 intake intake NN cord-322899-uxvlagt3 76 4 of of IN cord-322899-uxvlagt3 76 5 potassium potassium NN cord-322899-uxvlagt3 76 6 iodide iodide NN cord-322899-uxvlagt3 76 7 _SP cord-322899-uxvlagt3 76 8 Copper Copper NNP cord-322899-uxvlagt3 76 9 is be VBZ cord-322899-uxvlagt3 76 10 an an DT cord-322899-uxvlagt3 76 11 essential essential JJ cord-322899-uxvlagt3 76 12 nutrient nutrient NN cord-322899-uxvlagt3 76 13 for for IN cord-322899-uxvlagt3 76 14 the the DT cord-322899-uxvlagt3 76 15 development development NN cord-322899-uxvlagt3 76 16 and and CC cord-322899-uxvlagt3 76 17 maintenance maintenance NN cord-322899-uxvlagt3 76 18 of of IN cord-322899-uxvlagt3 76 19 the the DT cord-322899-uxvlagt3 76 20 human human JJ cord-322899-uxvlagt3 76 21 immune immune NN cord-322899-uxvlagt3 76 22 system system NN cord-322899-uxvlagt3 76 23 . . . cord-322899-uxvlagt3 77 1 Copper copper NN cord-322899-uxvlagt3 77 2 is be VBZ cord-322899-uxvlagt3 77 3 crucial crucial JJ cord-322899-uxvlagt3 77 4 for for IN cord-322899-uxvlagt3 77 5 the the DT cord-322899-uxvlagt3 77 6 generation generation NN cord-322899-uxvlagt3 77 7 and and CC cord-322899-uxvlagt3 77 8 response response NN cord-322899-uxvlagt3 77 9 of of IN cord-322899-uxvlagt3 77 10 IL-2 IL-2 NNP cord-322899-uxvlagt3 77 11 to to IN cord-322899-uxvlagt3 77 12 adaptive adaptive JJ cord-322899-uxvlagt3 77 13 immune immune JJ cord-322899-uxvlagt3 77 14 cells cell NNS cord-322899-uxvlagt3 77 15 , , , cord-322899-uxvlagt3 77 16 the the DT cord-322899-uxvlagt3 77 17 production production NN cord-322899-uxvlagt3 77 18 of of IN cord-322899-uxvlagt3 77 19 antibodies antibody NNS cord-322899-uxvlagt3 77 20 , , , cord-322899-uxvlagt3 77 21 maintaining maintain VBG cord-322899-uxvlagt3 77 22 intracellular intracellular JJ cord-322899-uxvlagt3 77 23 antioxidant antioxidant JJ cord-322899-uxvlagt3 77 24 balance balance NN cord-322899-uxvlagt3 77 25 , , , cord-322899-uxvlagt3 77 26 and and CC cord-322899-uxvlagt3 77 27 self self NN cord-322899-uxvlagt3 77 28 - - HYPH cord-322899-uxvlagt3 77 29 protection protection NN cord-322899-uxvlagt3 77 30 of of IN cord-322899-uxvlagt3 77 31 immune immune JJ cord-322899-uxvlagt3 77 32 cells cell NNS cord-322899-uxvlagt3 77 33 . . . cord-322899-uxvlagt3 78 1 [ [ -LRB- cord-322899-uxvlagt3 78 2 41 41 CD cord-322899-uxvlagt3 78 3 , , , cord-322899-uxvlagt3 78 4 42 42 CD cord-322899-uxvlagt3 78 5 ] ] -RRB- cord-322899-uxvlagt3 78 6 Copper copper NN cord-322899-uxvlagt3 78 7 deficiency deficiency NN cord-322899-uxvlagt3 78 8 can can MD cord-322899-uxvlagt3 78 9 lead lead VB cord-322899-uxvlagt3 78 10 to to IN cord-322899-uxvlagt3 78 11 increased increase VBN cord-322899-uxvlagt3 78 12 viral viral JJ cord-322899-uxvlagt3 78 13 virulence virulence NN cord-322899-uxvlagt3 78 14 , , , cord-322899-uxvlagt3 78 15 decreased decrease VBD cord-322899-uxvlagt3 78 16 IL-2 IL-2 NNP cord-322899-uxvlagt3 78 17 level level NN cord-322899-uxvlagt3 78 18 and and CC cord-322899-uxvlagt3 78 19 T t NN cord-322899-uxvlagt3 78 20 - - HYPH cord-322899-uxvlagt3 78 21 cell cell NN cord-322899-uxvlagt3 78 22 proliferation proliferation NN cord-322899-uxvlagt3 78 23 , , , cord-322899-uxvlagt3 78 24 and and CC cord-322899-uxvlagt3 78 25 reduced reduce VBN cord-322899-uxvlagt3 78 26 phagocytic phagocytic JJ cord-322899-uxvlagt3 78 27 ability ability NN cord-322899-uxvlagt3 78 28 . . . cord-322899-uxvlagt3 79 1 [ [ -LRB- cord-322899-uxvlagt3 79 2 43 43 CD cord-322899-uxvlagt3 79 3 ] ] -RRB- cord-322899-uxvlagt3 79 4 Copper copper NN cord-322899-uxvlagt3 79 5 exhibits exhibit VBZ cord-322899-uxvlagt3 79 6 a a DT cord-322899-uxvlagt3 79 7 potent potent JJ cord-322899-uxvlagt3 79 8 antiviral antiviral JJ cord-322899-uxvlagt3 79 9 property property NN cord-322899-uxvlagt3 79 10 , , , cord-322899-uxvlagt3 79 11 possibly possibly RB cord-322899-uxvlagt3 79 12 via via IN cord-322899-uxvlagt3 79 13 binding bind VBG cord-322899-uxvlagt3 79 14 electron electron NN cord-322899-uxvlagt3 79 15 donor donor NN cord-322899-uxvlagt3 79 16 groups group NNS cord-322899-uxvlagt3 79 17 on on IN cord-322899-uxvlagt3 79 18 viral viral JJ cord-322899-uxvlagt3 79 19 proteins protein NNS cord-322899-uxvlagt3 79 20 or or CC cord-322899-uxvlagt3 79 21 nucleic nucleic JJ cord-322899-uxvlagt3 79 22 acids acid NNS cord-322899-uxvlagt3 79 23 . . . cord-322899-uxvlagt3 80 1 [ [ -LRB- cord-322899-uxvlagt3 80 2 44 44 CD cord-322899-uxvlagt3 80 3 ] ] -RRB- cord-322899-uxvlagt3 80 4 Copper copper NN cord-322899-uxvlagt3 80 5 antiviral antiviral JJ cord-322899-uxvlagt3 80 6 effects effect NNS cord-322899-uxvlagt3 80 7 may may MD cord-322899-uxvlagt3 80 8 also also RB cord-322899-uxvlagt3 80 9 due due IN cord-322899-uxvlagt3 80 10 to to IN cord-322899-uxvlagt3 80 11 the the DT cord-322899-uxvlagt3 80 12 regulatory regulatory JJ cord-322899-uxvlagt3 80 13 roles role NNS cord-322899-uxvlagt3 80 14 of of IN cord-322899-uxvlagt3 80 15 copper copper NN cord-322899-uxvlagt3 80 16 on on IN cord-322899-uxvlagt3 80 17 certain certain JJ cord-322899-uxvlagt3 80 18 enzymes enzyme NNS cord-322899-uxvlagt3 80 19 , , , cord-322899-uxvlagt3 80 20 which which WDT cord-322899-uxvlagt3 80 21 are be VBP cord-322899-uxvlagt3 80 22 critical critical JJ cord-322899-uxvlagt3 80 23 for for IN cord-322899-uxvlagt3 80 24 the the DT cord-322899-uxvlagt3 80 25 function function NN cord-322899-uxvlagt3 80 26 of of IN cord-322899-uxvlagt3 80 27 various various JJ cord-322899-uxvlagt3 80 28 types type NNS cord-322899-uxvlagt3 80 29 of of IN cord-322899-uxvlagt3 80 30 immune immune JJ cord-322899-uxvlagt3 80 31 cells cell NNS cord-322899-uxvlagt3 80 32 . . . cord-322899-uxvlagt3 81 1 [ [ -LRB- cord-322899-uxvlagt3 81 2 42 42 CD cord-322899-uxvlagt3 81 3 , , , cord-322899-uxvlagt3 81 4 43 43 CD cord-322899-uxvlagt3 81 5 ] ] -RRB- cord-322899-uxvlagt3 82 1 In in IN cord-322899-uxvlagt3 82 2 addition addition NN cord-322899-uxvlagt3 82 3 , , , cord-322899-uxvlagt3 82 4 activated activate VBN cord-322899-uxvlagt3 82 5 macrophages macrophage NNS cord-322899-uxvlagt3 82 6 accumulate accumulate VBP cord-322899-uxvlagt3 82 7 copper copper NN cord-322899-uxvlagt3 82 8 within within IN cord-322899-uxvlagt3 82 9 the the DT cord-322899-uxvlagt3 82 10 phagosome phagosome NN cord-322899-uxvlagt3 82 11 to to TO cord-322899-uxvlagt3 82 12 inactivate inactivate VB cord-322899-uxvlagt3 82 13 the the DT cord-322899-uxvlagt3 82 14 pathogens pathogen NNS cord-322899-uxvlagt3 82 15 . . . cord-322899-uxvlagt3 83 1 This this DT cord-322899-uxvlagt3 83 2 event event NN cord-322899-uxvlagt3 83 3 plays play VBZ cord-322899-uxvlagt3 83 4 an an DT cord-322899-uxvlagt3 83 5 important important JJ cord-322899-uxvlagt3 83 6 role role NN cord-322899-uxvlagt3 83 7 in in IN cord-322899-uxvlagt3 83 8 the the DT cord-322899-uxvlagt3 83 9 control control NN cord-322899-uxvlagt3 83 10 of of IN cord-322899-uxvlagt3 83 11 pulmonary pulmonary JJ cord-322899-uxvlagt3 83 12 infections infection NNS cord-322899-uxvlagt3 83 13 . . . cord-322899-uxvlagt3 84 1 [ [ -LRB- cord-322899-uxvlagt3 84 2 45 45 CD cord-322899-uxvlagt3 84 3 ] ] -RRB- cord-322899-uxvlagt3 84 4 Intravenous Intravenous NNP cord-322899-uxvlagt3 84 5 copper copper NN cord-322899-uxvlagt3 84 6 administration administration NN cord-322899-uxvlagt3 84 7 results result VBZ cord-322899-uxvlagt3 84 8 in in IN cord-322899-uxvlagt3 84 9 a a DT cord-322899-uxvlagt3 84 10 greater great JJR cord-322899-uxvlagt3 84 11 copper copper NN cord-322899-uxvlagt3 84 12 concentration concentration NN cord-322899-uxvlagt3 84 13 in in IN cord-322899-uxvlagt3 84 14 the the DT cord-322899-uxvlagt3 84 15 lung lung NN cord-322899-uxvlagt3 84 16 [ [ -LRB- cord-322899-uxvlagt3 84 17 46 46 CD cord-322899-uxvlagt3 84 18 ] ] -RRB- cord-322899-uxvlagt3 84 19 , , , cord-322899-uxvlagt3 84 20 promotes promote VBZ cord-322899-uxvlagt3 84 21 the the DT cord-322899-uxvlagt3 84 22 anti anti JJ cord-322899-uxvlagt3 84 23 - - JJ cord-322899-uxvlagt3 84 24 inflammatory inflammatory JJ cord-322899-uxvlagt3 84 25 forkhead forkhead NNP cord-322899-uxvlagt3 84 26 box box NN cord-322899-uxvlagt3 84 27 P3-positive P3-positive NNP cord-322899-uxvlagt3 84 28 T T NNP cord-322899-uxvlagt3 84 29 - - HYPH cord-322899-uxvlagt3 84 30 cells cell NNS cord-322899-uxvlagt3 84 31 . . . cord-322899-uxvlagt3 85 1 [ [ -LRB- cord-322899-uxvlagt3 85 2 59 59 CD cord-322899-uxvlagt3 85 3 ] ] -RRB- cord-322899-uxvlagt3 86 1 Vitamin vitamin NN cord-322899-uxvlagt3 86 2 A a DT cord-322899-uxvlagt3 86 3 deficiency deficiency NN cord-322899-uxvlagt3 86 4 leads lead VBZ cord-322899-uxvlagt3 86 5 to to IN cord-322899-uxvlagt3 86 6 the the DT cord-322899-uxvlagt3 86 7 reduced reduce VBN cord-322899-uxvlagt3 86 8 weight weight NN cord-322899-uxvlagt3 86 9 of of IN cord-322899-uxvlagt3 86 10 the the DT cord-322899-uxvlagt3 86 11 thymus thymus NN cord-322899-uxvlagt3 86 12 , , , cord-322899-uxvlagt3 86 13 decreased decrease VBD cord-322899-uxvlagt3 86 14 lymphocyte lymphocyte NN cord-322899-uxvlagt3 86 15 proliferation proliferation NN cord-322899-uxvlagt3 86 16 , , , cord-322899-uxvlagt3 86 17 impaired impair VBN cord-322899-uxvlagt3 86 18 Tcell Tcell NNP cord-322899-uxvlagt3 86 19 - - HYPH cord-322899-uxvlagt3 86 20 mediated mediate VBN cord-322899-uxvlagt3 86 21 response response NN cord-322899-uxvlagt3 86 22 , , , cord-322899-uxvlagt3 86 23 and and CC cord-322899-uxvlagt3 86 24 enhanced enhanced JJ cord-322899-uxvlagt3 86 25 pathogen pathogen NN cord-322899-uxvlagt3 86 26 binding bind VBG cord-322899-uxvlagt3 86 27 to to IN cord-322899-uxvlagt3 86 28 respiratory respiratory JJ cord-322899-uxvlagt3 86 29 epithelial epithelial JJ cord-322899-uxvlagt3 86 30 tissues tissue NNS cord-322899-uxvlagt3 86 31 . . . cord-322899-uxvlagt3 87 1 [ [ -LRB- cord-322899-uxvlagt3 87 2 60 60 CD cord-322899-uxvlagt3 87 3 ] ] -RRB- cord-322899-uxvlagt3 87 4 Vitamin vitamin NN cord-322899-uxvlagt3 87 5 A a NN cord-322899-uxvlagt3 87 6 inhibits inhibit VBZ cord-322899-uxvlagt3 87 7 viral viral JJ cord-322899-uxvlagt3 87 8 replication replication NN cord-322899-uxvlagt3 87 9 , , , cord-322899-uxvlagt3 87 10 promotes promote VBZ cord-322899-uxvlagt3 87 11 the the DT cord-322899-uxvlagt3 87 12 immune immune JJ cord-322899-uxvlagt3 87 13 response response NN cord-322899-uxvlagt3 87 14 , , , cord-322899-uxvlagt3 87 15 and and CC cord-322899-uxvlagt3 87 16 decreases decrease VBZ cord-322899-uxvlagt3 87 17 morbidity morbidity NN cord-322899-uxvlagt3 87 18 and and CC cord-322899-uxvlagt3 87 19 mortality mortality NN cord-322899-uxvlagt3 87 20 of of IN cord-322899-uxvlagt3 87 21 some some DT cord-322899-uxvlagt3 87 22 viral viral JJ cord-322899-uxvlagt3 87 23 infections infection NNS cord-322899-uxvlagt3 87 24 . . . cord-322899-uxvlagt3 88 1 [ [ -LRB- cord-322899-uxvlagt3 88 2 61 61 CD cord-322899-uxvlagt3 88 3 ] ] -RRB- cord-322899-uxvlagt3 89 1 The the DT cord-322899-uxvlagt3 89 2 beneficial beneficial JJ cord-322899-uxvlagt3 89 3 effects effect NNS cord-322899-uxvlagt3 89 4 of of IN cord-322899-uxvlagt3 89 5 vitamin vitamin NN cord-322899-uxvlagt3 89 6 A a NN cord-322899-uxvlagt3 89 7 on on IN cord-322899-uxvlagt3 89 8 morbidity morbidity NN cord-322899-uxvlagt3 89 9 and and CC cord-322899-uxvlagt3 89 10 mortality mortality NN cord-322899-uxvlagt3 89 11 of of IN cord-322899-uxvlagt3 89 12 some some DT cord-322899-uxvlagt3 89 13 viral viral JJ cord-322899-uxvlagt3 89 14 infections infection NNS cord-322899-uxvlagt3 89 15 , , , cord-322899-uxvlagt3 89 16 such such JJ cord-322899-uxvlagt3 89 17 as as IN cord-322899-uxvlagt3 89 18 measles measle NNS cord-322899-uxvlagt3 89 19 and and CC cord-322899-uxvlagt3 89 20 HIV HIV NNP cord-322899-uxvlagt3 89 21 , , , cord-322899-uxvlagt3 89 22 could could MD cord-322899-uxvlagt3 89 23 be be VB cord-322899-uxvlagt3 89 24 due due JJ cord-322899-uxvlagt3 89 25 to to IN cord-322899-uxvlagt3 89 26 increased increase VBN cord-322899-uxvlagt3 89 27 antibody antibody NN cord-322899-uxvlagt3 89 28 production production NN cord-322899-uxvlagt3 89 29 and and CC cord-322899-uxvlagt3 89 30 lymphocyte lymphocyte NN cord-322899-uxvlagt3 89 31 proliferation proliferation NN cord-322899-uxvlagt3 89 32 as as RB cord-322899-uxvlagt3 89 33 well well RB cord-322899-uxvlagt3 89 34 as as IN cord-322899-uxvlagt3 89 35 enhanced enhance VBN cord-322899-uxvlagt3 89 36 T t NN cord-322899-uxvlagt3 89 37 - - HYPH cord-322899-uxvlagt3 89 38 cell cell NN cord-322899-uxvlagt3 89 39 lymphopoiesis lymphopoiesis NN cord-322899-uxvlagt3 89 40 . . . cord-322899-uxvlagt3 90 1 [ [ -LRB- cord-322899-uxvlagt3 90 2 62 62 CD cord-322899-uxvlagt3 90 3 ] ] -RRB- cord-322899-uxvlagt3 91 1 Clinical clinical JJ cord-322899-uxvlagt3 91 2 investigations investigation NNS cord-322899-uxvlagt3 91 3 and and CC cord-322899-uxvlagt3 91 4 in in IN cord-322899-uxvlagt3 91 5 vitro vitro FW cord-322899-uxvlagt3 91 6 studies study NNS cord-322899-uxvlagt3 91 7 have have VBP cord-322899-uxvlagt3 91 8 indicated indicate VBN cord-322899-uxvlagt3 91 9 that that IN cord-322899-uxvlagt3 91 10 vitamin vitamin NN cord-322899-uxvlagt3 91 11 A a NN cord-322899-uxvlagt3 91 12 is be VBZ cord-322899-uxvlagt3 91 13 the the DT cord-322899-uxvlagt3 91 14 main main JJ cord-322899-uxvlagt3 91 15 regulator regulator NN cord-322899-uxvlagt3 91 16 of of IN cord-322899-uxvlagt3 91 17 mucosal mucosal JJ cord-322899-uxvlagt3 91 18 immunity immunity NN cord-322899-uxvlagt3 91 19 and and CC cord-322899-uxvlagt3 91 20 could could MD cord-322899-uxvlagt3 91 21 affect affect VB cord-322899-uxvlagt3 91 22 immune immune JJ cord-322899-uxvlagt3 91 23 responses response NNS cord-322899-uxvlagt3 91 24 to to IN cord-322899-uxvlagt3 91 25 mucosal mucosal JJ cord-322899-uxvlagt3 91 26 infections infection NNS cord-322899-uxvlagt3 91 27 . . . cord-322899-uxvlagt3 92 1 levels level NNS cord-322899-uxvlagt3 92 2 as as RB cord-322899-uxvlagt3 92 3 well well RB cord-322899-uxvlagt3 92 4 as as IN cord-322899-uxvlagt3 92 5 an an DT cord-322899-uxvlagt3 92 6 enhancement enhancement NN cord-322899-uxvlagt3 92 7 of of IN cord-322899-uxvlagt3 92 8 CD4 CD4 NNP cord-322899-uxvlagt3 92 9 + + CC cord-322899-uxvlagt3 92 10 /CD8 /CD8 , cord-322899-uxvlagt3 92 11 + + CC cord-322899-uxvlagt3 92 12 ratio ratio NN cord-322899-uxvlagt3 92 13 and and CC cord-322899-uxvlagt3 92 14 TNF TNF NNP cord-322899-uxvlagt3 92 15 - - HYPH cord-322899-uxvlagt3 92 16 α α NNP cord-322899-uxvlagt3 92 17 value value NN cord-322899-uxvlagt3 92 18 . . . cord-322899-uxvlagt3 93 1 [ [ -LRB- cord-322899-uxvlagt3 93 2 41 41 CD cord-322899-uxvlagt3 93 3 ] ] -RRB- cord-322899-uxvlagt3 94 1 There there EX cord-322899-uxvlagt3 94 2 are be VBP cord-322899-uxvlagt3 94 3 several several JJ cord-322899-uxvlagt3 94 4 experimental experimental JJ cord-322899-uxvlagt3 94 5 and and CC cord-322899-uxvlagt3 94 6 clinical clinical JJ cord-322899-uxvlagt3 94 7 studies study NNS cord-322899-uxvlagt3 94 8 indicating indicate VBG cord-322899-uxvlagt3 94 9 the the DT cord-322899-uxvlagt3 94 10 antiviral antiviral JJ cord-322899-uxvlagt3 94 11 effects effect NNS cord-322899-uxvlagt3 94 12 of of IN cord-322899-uxvlagt3 94 13 B b NN cord-322899-uxvlagt3 94 14 vitamins vitamin NNS cord-322899-uxvlagt3 94 15 . . . cord-322899-uxvlagt3 95 1 Patients patient NNS cord-322899-uxvlagt3 95 2 with with IN cord-322899-uxvlagt3 95 3 HIV HIV NNP cord-322899-uxvlagt3 95 4 suffered suffer VBD cord-322899-uxvlagt3 95 5 from from IN cord-322899-uxvlagt3 95 6 a a DT cord-322899-uxvlagt3 95 7 high high JJ cord-322899-uxvlagt3 95 8 prevalence prevalence NN cord-322899-uxvlagt3 95 9 of of IN cord-322899-uxvlagt3 95 10 vitamin vitamin NN cord-322899-uxvlagt3 95 11 B1 b1 NN cord-322899-uxvlagt3 95 12 deficiency deficiency NN cord-322899-uxvlagt3 95 13 . . . cord-322899-uxvlagt3 96 1 Vitamin vitamin NN cord-322899-uxvlagt3 96 2 B1 b1 NN cord-322899-uxvlagt3 96 3 affects affect VBZ cord-322899-uxvlagt3 96 4 HIV HIV NNP cord-322899-uxvlagt3 96 5 infection infection NN cord-322899-uxvlagt3 96 6 via via IN cord-322899-uxvlagt3 96 7 non non JJ cord-322899-uxvlagt3 96 8 - - JJ cord-322899-uxvlagt3 96 9 genomic genomic JJ cord-322899-uxvlagt3 96 10 mechanisms mechanism NNS cord-322899-uxvlagt3 96 11 , , , cord-322899-uxvlagt3 96 12 which which WDT cord-322899-uxvlagt3 96 13 may may MD cord-322899-uxvlagt3 96 14 lead lead VB cord-322899-uxvlagt3 96 15 to to IN cord-322899-uxvlagt3 96 16 beneficial beneficial JJ cord-322899-uxvlagt3 96 17 effects effect NNS cord-322899-uxvlagt3 96 18 in in IN cord-322899-uxvlagt3 96 19 patients patient NNS cord-322899-uxvlagt3 96 20 with with IN cord-322899-uxvlagt3 96 21 HIV HIV NNP cord-322899-uxvlagt3 96 22 . . . cord-322899-uxvlagt3 97 1 [ [ -LRB- cord-322899-uxvlagt3 97 2 72 72 CD cord-322899-uxvlagt3 97 3 ] ] -RRB- cord-322899-uxvlagt3 97 4 Vitamin vitamin NN cord-322899-uxvlagt3 97 5 B2 b2 NN cord-322899-uxvlagt3 97 6 alone alone RB cord-322899-uxvlagt3 97 7 or or CC cord-322899-uxvlagt3 97 8 in in IN cord-322899-uxvlagt3 97 9 combination combination NN cord-322899-uxvlagt3 97 10 with with IN cord-322899-uxvlagt3 97 11 UV uv NN cord-322899-uxvlagt3 97 12 light light NN cord-322899-uxvlagt3 97 13 has have VBZ cord-322899-uxvlagt3 97 14 a a DT cord-322899-uxvlagt3 97 15 potent potent JJ cord-322899-uxvlagt3 97 16 antiviral antiviral JJ cord-322899-uxvlagt3 97 17 effect effect NN cord-322899-uxvlagt3 97 18 on on IN cord-322899-uxvlagt3 97 19 a a DT cord-322899-uxvlagt3 97 20 wide wide JJ cord-322899-uxvlagt3 97 21 range range NN cord-322899-uxvlagt3 97 22 of of IN cord-322899-uxvlagt3 97 23 viruses virus NNS cord-322899-uxvlagt3 97 24 , , , cord-322899-uxvlagt3 97 25 such such JJ cord-322899-uxvlagt3 97 26 as as IN cord-322899-uxvlagt3 97 27 MERS- MERS- NNP cord-322899-uxvlagt3 98 1 CoV. CoV. NNP cord-322899-uxvlagt3 99 1 [ [ -LRB- cord-322899-uxvlagt3 99 2 73 73 CD cord-322899-uxvlagt3 99 3 ] ] -RRB- cord-322899-uxvlagt3 99 4 Deficiencies Deficiencies NNPS cord-322899-uxvlagt3 99 5 in in IN cord-322899-uxvlagt3 99 6 vitamins vitamin NNS cord-322899-uxvlagt3 99 7 B6 b6 NN cord-322899-uxvlagt3 99 8 , , , cord-322899-uxvlagt3 99 9 B9 B9 NNP cord-322899-uxvlagt3 99 10 , , , cord-322899-uxvlagt3 99 11 and and CC cord-322899-uxvlagt3 99 12 B12 B12 NNP cord-322899-uxvlagt3 99 13 render render VB cord-322899-uxvlagt3 99 14 people people NNS cord-322899-uxvlagt3 99 15 more more RBR cord-322899-uxvlagt3 99 16 susceptible susceptible JJ cord-322899-uxvlagt3 99 17 to to IN cord-322899-uxvlagt3 99 18 viral viral JJ cord-322899-uxvlagt3 99 19 respiratory respiratory JJ cord-322899-uxvlagt3 99 20 infections infection NNS cord-322899-uxvlagt3 99 21 , , , cord-322899-uxvlagt3 99 22 such such JJ cord-322899-uxvlagt3 99 23 as as IN cord-322899-uxvlagt3 99 24 influenza influenza NN cord-322899-uxvlagt3 99 25 . . . cord-322899-uxvlagt3 100 1 [ [ -LRB- cord-322899-uxvlagt3 100 2 74 74 CD cord-322899-uxvlagt3 100 3 ] ] -RRB- cord-322899-uxvlagt3 101 1 It -PRON- PRP cord-322899-uxvlagt3 101 2 has have VBZ cord-322899-uxvlagt3 101 3 been be VBN cord-322899-uxvlagt3 101 4 suggested suggest VBN cord-322899-uxvlagt3 101 5 that that IN cord-322899-uxvlagt3 101 6 a a DT cord-322899-uxvlagt3 101 7 vitamin vitamin NN cord-322899-uxvlagt3 101 8 A a NN cord-322899-uxvlagt3 101 9 - - HYPH cord-322899-uxvlagt3 101 10 vitamin vitamin NN cord-322899-uxvlagt3 101 11 B6 b6 NN cord-322899-uxvlagt3 101 12 conjugate conjugate NN cord-322899-uxvlagt3 101 13 analogue analogue NN cord-322899-uxvlagt3 101 14 can can MD cord-322899-uxvlagt3 101 15 exert exert VB cord-322899-uxvlagt3 101 16 an an DT cord-322899-uxvlagt3 101 17 antiviral antiviral JJ cord-322899-uxvlagt3 101 18 effect effect NN cord-322899-uxvlagt3 101 19 by by IN cord-322899-uxvlagt3 101 20 regulating regulate VBG cord-322899-uxvlagt3 101 21 transcription transcription NN cord-322899-uxvlagt3 101 22 and/or and/or CC cord-322899-uxvlagt3 101 23 replication replication NN cord-322899-uxvlagt3 101 24 of of IN cord-322899-uxvlagt3 101 25 various various JJ cord-322899-uxvlagt3 101 26 RNA RNA NNP cord-322899-uxvlagt3 101 27 viruses virus NNS cord-322899-uxvlagt3 101 28 , , , cord-322899-uxvlagt3 101 29 including include VBG cord-322899-uxvlagt3 101 30 coronavirus coronavirus NN cord-322899-uxvlagt3 101 31 . . . cord-322899-uxvlagt3 102 1 [ [ -LRB- cord-322899-uxvlagt3 102 2 75 75 CD cord-322899-uxvlagt3 102 3 ] ] -RRB- cord-322899-uxvlagt3 102 4 Vitamin vitamin NN cord-322899-uxvlagt3 102 5 C c NN cord-322899-uxvlagt3 102 6 A a NN cord-322899-uxvlagt3 102 7 wide wide JJ cord-322899-uxvlagt3 102 8 range range NN cord-322899-uxvlagt3 102 9 of of IN cord-322899-uxvlagt3 102 10 studies study NNS cord-322899-uxvlagt3 102 11 points point VBZ cord-322899-uxvlagt3 102 12 to to IN cord-322899-uxvlagt3 102 13 the the DT cord-322899-uxvlagt3 102 14 importance importance NN cord-322899-uxvlagt3 102 15 of of IN cord-322899-uxvlagt3 102 16 vitamin vitamin NN cord-322899-uxvlagt3 102 17 C c NN cord-322899-uxvlagt3 102 18 in in IN cord-322899-uxvlagt3 102 19 immune immune JJ cord-322899-uxvlagt3 102 20 host host NN cord-322899-uxvlagt3 102 21 responses response NNS cord-322899-uxvlagt3 102 22 to to IN cord-322899-uxvlagt3 102 23 viral viral JJ cord-322899-uxvlagt3 102 24 infections infection NNS cord-322899-uxvlagt3 102 25 . . . cord-322899-uxvlagt3 103 1 Vitamin vitamin NN cord-322899-uxvlagt3 103 2 C C NNP cord-322899-uxvlagt3 103 3 promotes promote VBZ cord-322899-uxvlagt3 103 4 the the DT cord-322899-uxvlagt3 103 5 production production NN cord-322899-uxvlagt3 103 6 , , , cord-322899-uxvlagt3 103 7 function function NN cord-322899-uxvlagt3 103 8 , , , cord-322899-uxvlagt3 103 9 and and CC cord-322899-uxvlagt3 103 10 migration migration NN cord-322899-uxvlagt3 103 11 of of IN cord-322899-uxvlagt3 103 12 immune immune JJ cord-322899-uxvlagt3 103 13 cells cell NNS cord-322899-uxvlagt3 103 14 , , , cord-322899-uxvlagt3 103 15 and and CC cord-322899-uxvlagt3 103 16 enhances enhance VBZ cord-322899-uxvlagt3 103 17 serum serum NN cord-322899-uxvlagt3 103 18 values value NNS cord-322899-uxvlagt3 103 19 of of IN cord-322899-uxvlagt3 103 20 antibodies antibody NNS cord-322899-uxvlagt3 103 21 and and CC cord-322899-uxvlagt3 103 22 complement complement VB cord-322899-uxvlagt3 103 23 proteins protein NNS cord-322899-uxvlagt3 103 24 . . . cord-322899-uxvlagt3 104 1 [ [ -LRB- cord-322899-uxvlagt3 104 2 76 76 CD cord-322899-uxvlagt3 104 3 ] ] -RRB- cord-322899-uxvlagt3 105 1 Vitamin vitamin NN cord-322899-uxvlagt3 105 2 C C NNP cord-322899-uxvlagt3 105 3 also also RB cord-322899-uxvlagt3 105 4 supports support VBZ cord-322899-uxvlagt3 105 5 the the DT cord-322899-uxvlagt3 105 6 differentiation differentiation NN cord-322899-uxvlagt3 105 7 and and CC cord-322899-uxvlagt3 105 8 proliferation proliferation NN cord-322899-uxvlagt3 105 9 of of IN cord-322899-uxvlagt3 105 10 lymphocyte lymphocyte NN cord-322899-uxvlagt3 105 11 and and CC cord-322899-uxvlagt3 105 12 enhances enhance VBZ cord-322899-uxvlagt3 105 13 apoptosis apoptosis NN cord-322899-uxvlagt3 105 14 , , , cord-322899-uxvlagt3 105 15 chemotaxis chemotaxis NN cord-322899-uxvlagt3 105 16 , , , cord-322899-uxvlagt3 105 17 and and CC cord-322899-uxvlagt3 105 18 IFN IFN NNP cord-322899-uxvlagt3 105 19 production production NN cord-322899-uxvlagt3 105 20 . . . cord-322899-uxvlagt3 106 1 [ [ -LRB- cord-322899-uxvlagt3 106 2 77 77 CD cord-322899-uxvlagt3 106 3 ] ] -RRB- cord-322899-uxvlagt3 106 4 Clinical clinical JJ cord-322899-uxvlagt3 106 5 trials trial NNS cord-322899-uxvlagt3 106 6 and and CC cord-322899-uxvlagt3 106 7 experimental experimental JJ cord-322899-uxvlagt3 106 8 studies study NNS cord-322899-uxvlagt3 106 9 suggested suggest VBD cord-322899-uxvlagt3 106 10 that that IN cord-322899-uxvlagt3 106 11 vitamin vitamin NN cord-322899-uxvlagt3 106 12 C C NNP cord-322899-uxvlagt3 106 13 inhibits inhibit VBZ cord-322899-uxvlagt3 106 14 the the DT cord-322899-uxvlagt3 106 15 pro pro JJ cord-322899-uxvlagt3 106 16 - - JJ cord-322899-uxvlagt3 106 17 inflammatory inflammatory JJ cord-322899-uxvlagt3 106 18 cytokines cytokine NNS cord-322899-uxvlagt3 106 19 , , , cord-322899-uxvlagt3 106 20 like like IN cord-322899-uxvlagt3 106 21 TNF TNF NNP cord-322899-uxvlagt3 106 22 and and CC cord-322899-uxvlagt3 106 23 IL-6 IL-6 NNP cord-322899-uxvlagt3 106 24 , , , cord-322899-uxvlagt3 106 25 and and CC cord-322899-uxvlagt3 106 26 increases increase VBZ cord-322899-uxvlagt3 106 27 the the DT cord-322899-uxvlagt3 106 28 proinflammatory proinflammatory JJ cord-322899-uxvlagt3 106 29 cytokines cytokine NNS cord-322899-uxvlagt3 106 30 , , , cord-322899-uxvlagt3 106 31 such such JJ cord-322899-uxvlagt3 106 32 as as IN cord-322899-uxvlagt3 106 33 TNF TNF NNP cord-322899-uxvlagt3 106 34 , , , cord-322899-uxvlagt3 106 35 IL-6 IL-6 NNP cord-322899-uxvlagt3 106 36 , , , cord-322899-uxvlagt3 106 37 and and CC cord-322899-uxvlagt3 106 38 IL-1β IL-1β NNP cord-322899-uxvlagt3 106 39 . . . cord-322899-uxvlagt3 107 1 [ [ -LRB- cord-322899-uxvlagt3 107 2 78 78 CD cord-322899-uxvlagt3 107 3 ] ] -RRB- cord-322899-uxvlagt3 107 4 Vitamin vitamin NN cord-322899-uxvlagt3 107 5 C c NN cord-322899-uxvlagt3 107 6 exerts exert VBZ cord-322899-uxvlagt3 107 7 an an DT cord-322899-uxvlagt3 107 8 antiviral antiviral JJ cord-322899-uxvlagt3 107 9 immune immune JJ cord-322899-uxvlagt3 107 10 response response NN cord-322899-uxvlagt3 107 11 against against IN cord-322899-uxvlagt3 107 12 the the DT cord-322899-uxvlagt3 107 13 influenza influenza NN cord-322899-uxvlagt3 107 14 virus virus NN cord-322899-uxvlagt3 107 15 via via IN cord-322899-uxvlagt3 107 16 the the DT cord-322899-uxvlagt3 107 17 enhancement enhancement NN cord-322899-uxvlagt3 107 18 of of IN cord-322899-uxvlagt3 107 19 IFN IFN NNP cord-322899-uxvlagt3 107 20 - - HYPH cord-322899-uxvlagt3 107 21 IL-1α IL-1α NNP cord-322899-uxvlagt3 107 22 / / SYM cord-322899-uxvlagt3 107 23 β β NN cord-322899-uxvlagt3 107 24 production production NN cord-322899-uxvlagt3 107 25 . . . cord-322899-uxvlagt3 108 1 [ [ -LRB- cord-322899-uxvlagt3 108 2 79 79 CD cord-322899-uxvlagt3 108 3 ] ] -RRB- cord-322899-uxvlagt3 109 1 Vitamin vitamin NN cord-322899-uxvlagt3 109 2 C c NN cord-322899-uxvlagt3 109 3 enhances enhance VBZ cord-322899-uxvlagt3 109 4 the the DT cord-322899-uxvlagt3 109 5 resistance resistance NN cord-322899-uxvlagt3 109 6 of of IN cord-322899-uxvlagt3 109 7 broiler broiler NN cord-322899-uxvlagt3 109 8 chicks chick NNS cord-322899-uxvlagt3 109 9 [ [ -LRB- cord-322899-uxvlagt3 109 10 80 80 CD cord-322899-uxvlagt3 109 11 ] ] -RRB- cord-322899-uxvlagt3 109 12 and and CC cord-322899-uxvlagt3 109 13 chick chick NNP cord-322899-uxvlagt3 109 14 embryo embryo NNP cord-322899-uxvlagt3 109 15 tracheal tracheal JJ cord-322899-uxvlagt3 109 16 organ organ NN cord-322899-uxvlagt3 109 17 cultures culture NNS cord-322899-uxvlagt3 109 18 [ [ -LRB- cord-322899-uxvlagt3 109 19 81 81 CD cord-322899-uxvlagt3 109 20 ] ] -RRB- cord-322899-uxvlagt3 109 21 to to IN cord-322899-uxvlagt3 109 22 infections infection NNS cord-322899-uxvlagt3 109 23 induced induce VBN cord-322899-uxvlagt3 109 24 by by IN cord-322899-uxvlagt3 109 25 an an DT cord-322899-uxvlagt3 109 26 avian avian JJ cord-322899-uxvlagt3 109 27 coronavirus coronavirus NN cord-322899-uxvlagt3 109 28 . . . cord-322899-uxvlagt3 110 1 Vitamin vitamin NN cord-322899-uxvlagt3 110 2 C c NN cord-322899-uxvlagt3 110 3 reduced reduce VBD cord-322899-uxvlagt3 110 4 the the DT cord-322899-uxvlagt3 110 5 cytokine cytokine NN cord-322899-uxvlagt3 110 6 levels level NNS cord-322899-uxvlagt3 110 7 ( ( -LRB- cord-322899-uxvlagt3 110 8 TNF TNF NNP cord-322899-uxvlagt3 110 9 - - HYPH cord-322899-uxvlagt3 110 10 α α NNP cord-322899-uxvlagt3 110 11 and and CC cord-322899-uxvlagt3 110 12 IL-1β IL-1β NNP cord-322899-uxvlagt3 110 13 ) ) -RRB- cord-322899-uxvlagt3 110 14 in in IN cord-322899-uxvlagt3 110 15 an an DT cord-322899-uxvlagt3 110 16 animal animal NN cord-322899-uxvlagt3 110 17 model model NN cord-322899-uxvlagt3 110 18 of of IN cord-322899-uxvlagt3 110 19 acute acute JJ cord-322899-uxvlagt3 110 20 respiratory respiratory JJ cord-322899-uxvlagt3 110 21 distress distress NN cord-322899-uxvlagt3 110 22 syndrome syndrome NN cord-322899-uxvlagt3 110 23 ( ( -LRB- cord-322899-uxvlagt3 110 24 ARDS ARDS NNP cord-322899-uxvlagt3 110 25 ) ) -RRB- cord-322899-uxvlagt3 110 26 ; ; : cord-322899-uxvlagt3 110 27 suggesting suggest VBG cord-322899-uxvlagt3 110 28 its -PRON- PRP$ cord-322899-uxvlagt3 110 29 beneficial beneficial JJ cord-322899-uxvlagt3 110 30 effect effect NN cord-322899-uxvlagt3 110 31 for for IN cord-322899-uxvlagt3 110 32 the the DT cord-322899-uxvlagt3 110 33 treatment treatment NN cord-322899-uxvlagt3 110 34 of of IN cord-322899-uxvlagt3 110 35 similar similar JJ cord-322899-uxvlagt3 110 36 inflammatory inflammatory JJ cord-322899-uxvlagt3 110 37 disorders disorder NNS cord-322899-uxvlagt3 110 38 . . . cord-322899-uxvlagt3 111 1 [ [ -LRB- cord-322899-uxvlagt3 111 2 82 82 CD cord-322899-uxvlagt3 111 3 ] ] -RRB- cord-322899-uxvlagt3 112 1 Indeed indeed RB cord-322899-uxvlagt3 112 2 , , , cord-322899-uxvlagt3 112 3 the the DT cord-322899-uxvlagt3 112 4 intravenous intravenous JJ cord-322899-uxvlagt3 112 5 administration administration NN cord-322899-uxvlagt3 112 6 of of IN cord-322899-uxvlagt3 112 7 vitamin vitamin NN cord-322899-uxvlagt3 112 8 C C NNP cord-322899-uxvlagt3 112 9 in in IN cord-322899-uxvlagt3 112 10 patients patient NNS cord-322899-uxvlagt3 112 11 suffering suffer VBG cord-322899-uxvlagt3 112 12 from from IN cord-322899-uxvlagt3 112 13 sepsis sepsis NN cord-322899-uxvlagt3 112 14 and and CC cord-322899-uxvlagt3 112 15 ARDS ARDS NNP cord-322899-uxvlagt3 112 16 significantly significantly RB cord-322899-uxvlagt3 112 17 reduced reduce VBD cord-322899-uxvlagt3 112 18 the the DT cord-322899-uxvlagt3 112 19 mortality mortality NN cord-322899-uxvlagt3 112 20 rate rate NN cord-322899-uxvlagt3 112 21 . . . cord-322899-uxvlagt3 113 1 [ [ -LRB- cord-322899-uxvlagt3 113 2 83 83 CD cord-322899-uxvlagt3 113 3 ] ] -RRB- cord-322899-uxvlagt3 114 1 Several several JJ cord-322899-uxvlagt3 114 2 investigations investigation NNS cord-322899-uxvlagt3 114 3 have have VBP cord-322899-uxvlagt3 114 4 suggested suggest VBN cord-322899-uxvlagt3 114 5 that that IN cord-322899-uxvlagt3 114 6 vitamin vitamin NN cord-322899-uxvlagt3 114 7 C c NN cord-322899-uxvlagt3 114 8 in in IN cord-322899-uxvlagt3 114 9 high high JJ cord-322899-uxvlagt3 114 10 dosages dosage NNS cord-322899-uxvlagt3 114 11 has have VBZ cord-322899-uxvlagt3 114 12 direct direct JJ cord-322899-uxvlagt3 114 13 virucidal virucidal JJ cord-322899-uxvlagt3 114 14 effects effect NNS cord-322899-uxvlagt3 114 15 . . . cord-322899-uxvlagt3 115 1 [ [ -LRB- cord-322899-uxvlagt3 115 2 84 84 CD cord-322899-uxvlagt3 115 3 ] ] -RRB- cord-322899-uxvlagt3 115 4 Several several JJ cord-322899-uxvlagt3 115 5 clinical clinical JJ cord-322899-uxvlagt3 115 6 trials trial NNS cord-322899-uxvlagt3 115 7 have have VBP cord-322899-uxvlagt3 115 8 shown show VBN cord-322899-uxvlagt3 115 9 a a DT cord-322899-uxvlagt3 115 10 significantly significantly RB cord-322899-uxvlagt3 115 11 lower low JJR cord-322899-uxvlagt3 115 12 incidence incidence NN cord-322899-uxvlagt3 115 13 of of IN cord-322899-uxvlagt3 115 14 RTI RTI NNP cord-322899-uxvlagt3 115 15 in in IN cord-322899-uxvlagt3 115 16 vitamin vitamin NN cord-322899-uxvlagt3 115 17 C c NN cord-322899-uxvlagt3 115 18 - - HYPH cord-322899-uxvlagt3 115 19 treated treat VBN cord-322899-uxvlagt3 115 20 subjects subject NNS cord-322899-uxvlagt3 115 21 . . . cord-322899-uxvlagt3 116 1 [ [ -LRB- cord-322899-uxvlagt3 116 2 85 85 CD cord-322899-uxvlagt3 116 3 ] ] -RRB- cord-322899-uxvlagt3 117 1 On on IN cord-322899-uxvlagt3 117 2 the the DT cord-322899-uxvlagt3 117 3 contrary contrary NN cord-322899-uxvlagt3 117 4 , , , cord-322899-uxvlagt3 117 5 vitamin vitamin NN cord-322899-uxvlagt3 117 6 C C NNP cord-322899-uxvlagt3 117 7 deficiency deficiency NN cord-322899-uxvlagt3 117 8 enhances enhance VBZ cord-322899-uxvlagt3 117 9 the the DT cord-322899-uxvlagt3 117 10 risk risk NN cord-322899-uxvlagt3 117 11 of of IN cord-322899-uxvlagt3 117 12 respiratory respiratory JJ cord-322899-uxvlagt3 117 13 infections infection NNS cord-322899-uxvlagt3 117 14 , , , cord-322899-uxvlagt3 117 15 particularly particularly RB cord-322899-uxvlagt3 117 16 in in IN cord-322899-uxvlagt3 117 17 the the DT cord-322899-uxvlagt3 117 18 elderly elderly JJ cord-322899-uxvlagt3 117 19 . . . cord-322899-uxvlagt3 118 1 Vitamin vitamin NN cord-322899-uxvlagt3 118 2 D d NN cord-322899-uxvlagt3 118 3 deficiency deficiency NN cord-322899-uxvlagt3 118 4 was be VBD cord-322899-uxvlagt3 118 5 associated associate VBN cord-322899-uxvlagt3 118 6 with with IN cord-322899-uxvlagt3 118 7 higher high JJR cord-322899-uxvlagt3 118 8 illness illness NN cord-322899-uxvlagt3 118 9 severity severity NN cord-322899-uxvlagt3 118 10 , , , cord-322899-uxvlagt3 118 11 multiple multiple JJ cord-322899-uxvlagt3 118 12 organ organ NN cord-322899-uxvlagt3 118 13 dysfunctions dysfunction NNS cord-322899-uxvlagt3 118 14 , , , cord-322899-uxvlagt3 118 15 and and CC cord-322899-uxvlagt3 118 16 mortality mortality NN cord-322899-uxvlagt3 118 17 in in IN cord-322899-uxvlagt3 118 18 critically critically RB cord-322899-uxvlagt3 118 19 ill ill JJ cord-322899-uxvlagt3 118 20 subjects subject NNS cord-322899-uxvlagt3 118 21 , , , cord-322899-uxvlagt3 118 22 particularly particularly RB cord-322899-uxvlagt3 118 23 with with IN cord-322899-uxvlagt3 118 24 sepsis sepsis NN cord-322899-uxvlagt3 118 25 and and CC cord-322899-uxvlagt3 118 26 pneumonia pneumonia NN cord-322899-uxvlagt3 118 27 . . . cord-322899-uxvlagt3 118 28 _SP cord-322899-uxvlagt3 119 1 Vitamin vitamin NN cord-322899-uxvlagt3 119 2 E e NN cord-322899-uxvlagt3 119 3 supports support VBZ cord-322899-uxvlagt3 119 4 the the DT cord-322899-uxvlagt3 119 5 integrity integrity NN cord-322899-uxvlagt3 119 6 of of IN cord-322899-uxvlagt3 119 7 epithelial epithelial JJ cord-322899-uxvlagt3 119 8 membranes membrane NNS cord-322899-uxvlagt3 119 9 and and CC cord-322899-uxvlagt3 119 10 increases increase VBZ cord-322899-uxvlagt3 119 11 IL-2 il-2 NN cord-322899-uxvlagt3 119 12 production production NN cord-322899-uxvlagt3 119 13 , , , cord-322899-uxvlagt3 119 14 NK NK NNP cord-322899-uxvlagt3 119 15 cell cell NN cord-322899-uxvlagt3 119 16 activity activity NN cord-322899-uxvlagt3 119 17 , , , cord-322899-uxvlagt3 119 18 T t NN cord-322899-uxvlagt3 119 19 - - HYPH cord-322899-uxvlagt3 119 20 cell cell NN cord-322899-uxvlagt3 119 21 - - HYPH cord-322899-uxvlagt3 119 22 mediated mediate VBN cord-322899-uxvlagt3 119 23 functions function NNS cord-322899-uxvlagt3 119 24 , , , cord-322899-uxvlagt3 119 25 and and CC cord-322899-uxvlagt3 119 26 lymphocyte lymphocyte NN cord-322899-uxvlagt3 119 27 proliferation proliferation NN cord-322899-uxvlagt3 119 28 . . . cord-322899-uxvlagt3 120 1 Furthermore furthermore RB cord-322899-uxvlagt3 120 2 , , , cord-322899-uxvlagt3 120 3 vitamin vitamin NN cord-322899-uxvlagt3 120 4 E e NN cord-322899-uxvlagt3 120 5 initiates initiate VBZ cord-322899-uxvlagt3 120 6 T t NN cord-322899-uxvlagt3 120 7 - - HYPH cord-322899-uxvlagt3 120 8 cell cell NN cord-322899-uxvlagt3 120 9 activation activation NN cord-322899-uxvlagt3 120 10 , , , cord-322899-uxvlagt3 120 11 promotes promote VBZ cord-322899-uxvlagt3 120 12 Th1 th1 NN cord-322899-uxvlagt3 120 13 proliferation proliferation NN cord-322899-uxvlagt3 120 14 , , , cord-322899-uxvlagt3 120 15 and and CC cord-322899-uxvlagt3 120 16 inhibits inhibit VBZ cord-322899-uxvlagt3 120 17 Th2 Th2 NNP cord-322899-uxvlagt3 120 18 response response NN cord-322899-uxvlagt3 120 19 . . . cord-322899-uxvlagt3 121 1 [ [ -LRB- cord-322899-uxvlagt3 121 2 101 101 CD cord-322899-uxvlagt3 121 3 ] ] -RRB- cord-322899-uxvlagt3 122 1 Vitamin vitamin NN cord-322899-uxvlagt3 122 2 E e NN cord-322899-uxvlagt3 122 3 supplementation supplementation NN cord-322899-uxvlagt3 122 4 causes cause VBZ cord-322899-uxvlagt3 122 5 a a DT cord-322899-uxvlagt3 122 6 higher high JJR cord-322899-uxvlagt3 122 7 IL-2 IL-2 NNP cord-322899-uxvlagt3 122 8 and and CC cord-322899-uxvlagt3 122 9 IFN IFN NNP cord-322899-uxvlagt3 122 10 - - HYPH cord-322899-uxvlagt3 122 11 γ γ NN cord-322899-uxvlagt3 122 12 production production NN cord-322899-uxvlagt3 122 13 with with IN cord-322899-uxvlagt3 122 14 a a DT cord-322899-uxvlagt3 122 15 lower low JJR cord-322899-uxvlagt3 122 16 lung lung NN cord-322899-uxvlagt3 122 17 virus virus NN cord-322899-uxvlagt3 122 18 titer titer NN cord-322899-uxvlagt3 122 19 in in IN cord-322899-uxvlagt3 122 20 animals animal NNS cord-322899-uxvlagt3 122 21 with with IN cord-322899-uxvlagt3 122 22 the the DT cord-322899-uxvlagt3 122 23 influenza influenza NN cord-322899-uxvlagt3 122 24 virus virus NN cord-322899-uxvlagt3 122 25 . . . cord-322899-uxvlagt3 123 1 [ [ -LRB- cord-322899-uxvlagt3 123 2 102 102 CD cord-322899-uxvlagt3 123 3 ] ] -RRB- cord-322899-uxvlagt3 124 1 Vitamin vitamin NN cord-322899-uxvlagt3 124 2 E e NN cord-322899-uxvlagt3 124 3 deficiency deficiency NN cord-322899-uxvlagt3 124 4 markedly markedly RB cord-322899-uxvlagt3 124 5 increases increase VBZ cord-322899-uxvlagt3 124 6 the the DT cord-322899-uxvlagt3 124 7 viral viral JJ cord-322899-uxvlagt3 124 8 pathogenicity pathogenicity NN cord-322899-uxvlagt3 124 9 and and CC cord-322899-uxvlagt3 124 10 heart heart NN cord-322899-uxvlagt3 124 11 damage damage NN cord-322899-uxvlagt3 124 12 in in IN cord-322899-uxvlagt3 124 13 mice mouse NNS cord-322899-uxvlagt3 124 14 infected infect VBN cord-322899-uxvlagt3 124 15 with with IN cord-322899-uxvlagt3 124 16 Coxsackieviruses Coxsackieviruses NNP cord-322899-uxvlagt3 124 17 - - HYPH cord-322899-uxvlagt3 124 18 B3 B3 NNP cord-322899-uxvlagt3 124 19 . . . cord-322899-uxvlagt3 125 1 [ [ -LRB- cord-322899-uxvlagt3 125 2 103 103 CD cord-322899-uxvlagt3 125 3 ] ] -RRB- cord-322899-uxvlagt3 125 4 Administration Administration NNP cord-322899-uxvlagt3 125 5 of of IN cord-322899-uxvlagt3 125 6 Vitamin vitamin NN cord-322899-uxvlagt3 125 7 E e NN cord-322899-uxvlagt3 125 8 increased increase VBN cord-322899-uxvlagt3 125 9 lymphocyte lymphocyte NN cord-322899-uxvlagt3 125 10 proliferation proliferation NN cord-322899-uxvlagt3 125 11 as as RB cord-322899-uxvlagt3 125 12 well well RB cord-322899-uxvlagt3 125 13 as as IN cord-322899-uxvlagt3 125 14 IL-2 il-2 NN cord-322899-uxvlagt3 125 15 and and CC cord-322899-uxvlagt3 125 16 IFNγ IFNγ NNS cord-322899-uxvlagt3 125 17 production production NN cord-322899-uxvlagt3 125 18 in in IN cord-322899-uxvlagt3 125 19 healthy healthy JJ cord-322899-uxvlagt3 125 20 subjects subject NNS cord-322899-uxvlagt3 125 21 and and CC cord-322899-uxvlagt3 125 22 aged aged JJ cord-322899-uxvlagt3 125 23 mice mouse NNS cord-322899-uxvlagt3 125 24 after after IN cord-322899-uxvlagt3 125 25 influenza influenza NN cord-322899-uxvlagt3 125 26 infections infection NNS cord-322899-uxvlagt3 125 27 . . . cord-322899-uxvlagt3 126 1 [ [ -LRB- cord-322899-uxvlagt3 126 2 102 102 CD cord-322899-uxvlagt3 126 3 ] ] -RRB- cord-322899-uxvlagt3 127 1 A a DT cord-322899-uxvlagt3 127 2 modest modest JJ cord-322899-uxvlagt3 127 3 level level NN cord-322899-uxvlagt3 127 4 of of IN cord-322899-uxvlagt3 127 5 vitamin vitamin NN cord-322899-uxvlagt3 127 6 E e NN cord-322899-uxvlagt3 127 7 supplementation supplementation NN cord-322899-uxvlagt3 127 8 regulates regulate VBZ cord-322899-uxvlagt3 127 9 the the DT cord-322899-uxvlagt3 127 10 cellular cellular JJ cord-322899-uxvlagt3 127 11 free free JJ cord-322899-uxvlagt3 127 12 radical radical JJ cord-322899-uxvlagt3 127 13 - - HYPH cord-322899-uxvlagt3 127 14 antioxidant antioxidant NN cord-322899-uxvlagt3 127 15 balance balance NN cord-322899-uxvlagt3 127 16 , , , cord-322899-uxvlagt3 127 17 enhances enhance VBZ cord-322899-uxvlagt3 127 18 the the DT cord-322899-uxvlagt3 127 19 antibody antibody NN cord-322899-uxvlagt3 127 20 response response NN cord-322899-uxvlagt3 127 21 , , , cord-322899-uxvlagt3 127 22 and and CC cord-322899-uxvlagt3 127 23 activates activate VBZ cord-322899-uxvlagt3 127 24 the the DT cord-322899-uxvlagt3 127 25 immune immune JJ cord-322899-uxvlagt3 127 26 cells cell NNS cord-322899-uxvlagt3 127 27 of of IN cord-322899-uxvlagt3 127 28 broilers broiler NNS cord-322899-uxvlagt3 127 29 vaccinated vaccinate VBN cord-322899-uxvlagt3 127 30 with with IN cord-322899-uxvlagt3 127 31 the the DT cord-322899-uxvlagt3 127 32 infectious infectious JJ cord-322899-uxvlagt3 127 33 bronchitis bronchitis NN cord-322899-uxvlagt3 127 34 virus virus NN cord-322899-uxvlagt3 127 35 . . . cord-322899-uxvlagt3 128 1 [ [ -LRB- cord-322899-uxvlagt3 128 2 104 104 CD cord-322899-uxvlagt3 128 3 ] ] -RRB- cord-322899-uxvlagt3 128 4 H1N1-infected h1n1-infecte VBN cord-322899-uxvlagt3 128 5 mice mouse NNS cord-322899-uxvlagt3 128 6 have have VBP cord-322899-uxvlagt3 128 7 shown show VBN cord-322899-uxvlagt3 128 8 positive positive JJ cord-322899-uxvlagt3 128 9 associations association NNS cord-322899-uxvlagt3 128 10 between between IN cord-322899-uxvlagt3 128 11 anti anti JJ cord-322899-uxvlagt3 128 12 - - JJ cord-322899-uxvlagt3 128 13 inflammatory inflammatory JJ cord-322899-uxvlagt3 128 14 cytokine cytokine NN cord-322899-uxvlagt3 128 15 IL-10 IL-10 NNP cord-322899-uxvlagt3 128 16 level level NN cord-322899-uxvlagt3 128 17 and and CC cord-322899-uxvlagt3 128 18 vitamin vitamin NN cord-322899-uxvlagt3 128 19 E e NN cord-322899-uxvlagt3 128 20 metabolism metabolism NN cord-322899-uxvlagt3 128 21 . . . cord-322899-uxvlagt3 129 1 [ [ -LRB- cord-322899-uxvlagt3 129 2 105 105 CD cord-322899-uxvlagt3 129 3 ] ] -RRB- cord-322899-uxvlagt3 129 4 Vitamin vitamin NN cord-322899-uxvlagt3 129 5 E e NN cord-322899-uxvlagt3 129 6 and and CC cord-322899-uxvlagt3 129 7 selenium selenium NN cord-322899-uxvlagt3 129 8 exhibit exhibit NN cord-322899-uxvlagt3 129 9 strong strong JJ cord-322899-uxvlagt3 129 10 control control NN cord-322899-uxvlagt3 129 11 over over IN cord-322899-uxvlagt3 129 12 viral viral JJ cord-322899-uxvlagt3 129 13 replication replication NN cord-322899-uxvlagt3 129 14 and and CC cord-322899-uxvlagt3 129 15 mutation mutation NN cord-322899-uxvlagt3 129 16 . . . cord-322899-uxvlagt3 130 1 In in IN cord-322899-uxvlagt3 130 2 a a DT cord-322899-uxvlagt3 130 3 nutritional nutritional JJ cord-322899-uxvlagt3 130 4 deficiency deficiency NN cord-322899-uxvlagt3 130 5 condition condition NN cord-322899-uxvlagt3 130 6 of of IN cord-322899-uxvlagt3 130 7 these these DT cord-322899-uxvlagt3 130 8 micronutrients micronutrient NNS cord-322899-uxvlagt3 130 9 , , , cord-322899-uxvlagt3 130 10 RNA RNA NNP cord-322899-uxvlagt3 130 11 viruses virus NNS cord-322899-uxvlagt3 130 12 are be VBP cord-322899-uxvlagt3 130 13 able able JJ cord-322899-uxvlagt3 130 14 to to TO cord-322899-uxvlagt3 130 15 convert convert VB cord-322899-uxvlagt3 130 16 to to IN cord-322899-uxvlagt3 130 17 more more JJR cord-322899-uxvlagt3 130 18 virulent virulent JJ cord-322899-uxvlagt3 130 19 strains strain NNS cord-322899-uxvlagt3 130 20 . . . cord-322899-uxvlagt3 131 1 [ [ -LRB- cord-322899-uxvlagt3 131 2 106 106 CD cord-322899-uxvlagt3 131 3 ] ] -RRB- cord-322899-uxvlagt3 132 1 Vitamin vitamin NN cord-322899-uxvlagt3 132 2 E e NN cord-322899-uxvlagt3 132 3 deficient deficient JJ cord-322899-uxvlagt3 132 4 mice mouse NNS cord-322899-uxvlagt3 132 5 failed fail VBD cord-322899-uxvlagt3 132 6 to to TO cord-322899-uxvlagt3 132 7 exhibit exhibit VB cord-322899-uxvlagt3 132 8 an an DT cord-322899-uxvlagt3 132 9 appropriate appropriate JJ cord-322899-uxvlagt3 132 10 immune immune JJ cord-322899-uxvlagt3 132 11 response response NN cord-322899-uxvlagt3 132 12 to to IN cord-322899-uxvlagt3 132 13 HSV-1 hsv-1 NN cord-322899-uxvlagt3 132 14 infection infection NN cord-322899-uxvlagt3 132 15 . . . cord-322899-uxvlagt3 133 1 [ [ -LRB- cord-322899-uxvlagt3 133 2 107 107 CD cord-322899-uxvlagt3 133 3 ] ] -RRB- cord-322899-uxvlagt3 134 1 A a DT cord-322899-uxvlagt3 134 2 significant significant JJ cord-322899-uxvlagt3 134 3 increase increase NN cord-322899-uxvlagt3 134 4 in in IN cord-322899-uxvlagt3 134 5 lung lung NN cord-322899-uxvlagt3 134 6 and and CC cord-322899-uxvlagt3 134 7 serum serum NN cord-322899-uxvlagt3 134 8 vitamin vitamin NN cord-322899-uxvlagt3 134 9 E e NN cord-322899-uxvlagt3 134 10 levels level NNS cord-322899-uxvlagt3 134 11 has have VBZ cord-322899-uxvlagt3 134 12 been be VBN cord-322899-uxvlagt3 134 13 observed observe VBN cord-322899-uxvlagt3 134 14 a a DT cord-322899-uxvlagt3 134 15 few few JJ cord-322899-uxvlagt3 134 16 days day NNS cord-322899-uxvlagt3 134 17 after after IN cord-322899-uxvlagt3 134 18 infection infection NN cord-322899-uxvlagt3 134 19 with with IN cord-322899-uxvlagt3 134 20 the the DT cord-322899-uxvlagt3 134 21 influenza influenza NN cord-322899-uxvlagt3 134 22 virus virus NN cord-322899-uxvlagt3 134 23 in in IN cord-322899-uxvlagt3 134 24 mice mouse NNS cord-322899-uxvlagt3 134 25 . . . cord-322899-uxvlagt3 135 1 [ [ -LRB- cord-322899-uxvlagt3 135 2 108 108 CD cord-322899-uxvlagt3 135 3 ] ] -RRB- cord-322899-uxvlagt3 136 1 Critically critically RB cord-322899-uxvlagt3 136 2 ill ill JJ cord-322899-uxvlagt3 136 3 patients patient NNS cord-322899-uxvlagt3 136 4 who who WP cord-322899-uxvlagt3 136 5 were be VBD cord-322899-uxvlagt3 136 6 admitted admit VBN cord-322899-uxvlagt3 136 7 to to IN cord-322899-uxvlagt3 136 8 an an DT cord-322899-uxvlagt3 136 9 ICU ICU NNP cord-322899-uxvlagt3 136 10 with with IN cord-322899-uxvlagt3 136 11 ARDS ARDS NNP cord-322899-uxvlagt3 136 12 have have VBP cord-322899-uxvlagt3 136 13 shown show VBN cord-322899-uxvlagt3 136 14 a a DT cord-322899-uxvlagt3 136 15 significant significant JJ cord-322899-uxvlagt3 136 16 reduction reduction NN cord-322899-uxvlagt3 136 17 of of IN cord-322899-uxvlagt3 136 18 vitamin vitamin NN cord-322899-uxvlagt3 136 19 E e NN cord-322899-uxvlagt3 136 20 plasma plasma NN cord-322899-uxvlagt3 136 21 level level NN cord-322899-uxvlagt3 136 22 . . . cord-322899-uxvlagt3 137 1 [ [ -LRB- cord-322899-uxvlagt3 137 2 109 109 CD cord-322899-uxvlagt3 137 3 ] ] -RRB- cord-322899-uxvlagt3 138 1 The the DT cord-322899-uxvlagt3 138 2 use use NN cord-322899-uxvlagt3 138 3 of of IN cord-322899-uxvlagt3 138 4 Vitamins Vitamins NNP cord-322899-uxvlagt3 138 5 E E NNP cord-322899-uxvlagt3 138 6 and and CC cord-322899-uxvlagt3 138 7 C C NNP cord-322899-uxvlagt3 138 8 in in IN cord-322899-uxvlagt3 138 9 critically critically RB cord-322899-uxvlagt3 138 10 ill ill JJ cord-322899-uxvlagt3 138 11 patients patient NNS cord-322899-uxvlagt3 138 12 reduced reduce VBD cord-322899-uxvlagt3 138 13 the the DT cord-322899-uxvlagt3 138 14 incidence incidence NN cord-322899-uxvlagt3 138 15 of of IN cord-322899-uxvlagt3 138 16 ARDS ARDS NNP cord-322899-uxvlagt3 138 17 and and CC cord-322899-uxvlagt3 138 18 pneumonia pneumonia NN cord-322899-uxvlagt3 138 19 and and CC cord-322899-uxvlagt3 138 20 shortened shorten VBN cord-322899-uxvlagt3 138 21 ICU ICU NNP cord-322899-uxvlagt3 138 22 length length NN cord-322899-uxvlagt3 138 23 of of IN cord-322899-uxvlagt3 138 24 stay stay NN cord-322899-uxvlagt3 138 25 . . . cord-322899-uxvlagt3 139 1 [ [ -LRB- cord-322899-uxvlagt3 139 2 110 110 CD cord-322899-uxvlagt3 139 3 ] ] -RRB- cord-322899-uxvlagt3 139 4 _SP cord-322899-uxvlagt3 140 1 The the DT cord-322899-uxvlagt3 140 2 most most RBS cord-322899-uxvlagt3 140 3 vulnerable vulnerable JJ cord-322899-uxvlagt3 140 4 groups group NNS cord-322899-uxvlagt3 140 5 to to IN cord-322899-uxvlagt3 140 6 the the DT cord-322899-uxvlagt3 140 7 severe severe RB cord-322899-uxvlagt3 140 8 - - HYPH cord-322899-uxvlagt3 140 9 critical critical JJ cord-322899-uxvlagt3 140 10 complications complication NNS cord-322899-uxvlagt3 140 11 of of IN cord-322899-uxvlagt3 140 12 COVID-19 COVID-19 NNP cord-322899-uxvlagt3 140 13 are be VBP cord-322899-uxvlagt3 140 14 the the DT cord-322899-uxvlagt3 140 15 elderly elderly JJ cord-322899-uxvlagt3 140 16 above above IN cord-322899-uxvlagt3 140 17 the the DT cord-322899-uxvlagt3 140 18 age age NN cord-322899-uxvlagt3 140 19 of of IN cord-322899-uxvlagt3 140 20 60 60 CD cord-322899-uxvlagt3 140 21 and and CC cord-322899-uxvlagt3 140 22 subjects subject NNS cord-322899-uxvlagt3 140 23 with with IN cord-322899-uxvlagt3 140 24 chronic chronic JJ cord-322899-uxvlagt3 140 25 diseases disease NNS cord-322899-uxvlagt3 140 26 , , , cord-322899-uxvlagt3 140 27 including include VBG cord-322899-uxvlagt3 140 28 hypertension hypertension NN cord-322899-uxvlagt3 140 29 , , , cord-322899-uxvlagt3 140 30 diabetes diabetes NN cord-322899-uxvlagt3 140 31 , , , cord-322899-uxvlagt3 140 32 and and CC cord-322899-uxvlagt3 140 33 cardiovascular cardiovascular JJ cord-322899-uxvlagt3 140 34 or or CC cord-322899-uxvlagt3 140 35 respiratory respiratory JJ cord-322899-uxvlagt3 140 36 diseases disease NNS cord-322899-uxvlagt3 140 37 . . . cord-322899-uxvlagt3 141 1 [ [ -LRB- cord-322899-uxvlagt3 141 2 111 111 CD cord-322899-uxvlagt3 141 3 , , , cord-322899-uxvlagt3 141 4 112 112 CD cord-322899-uxvlagt3 141 5 ] ] -RRB- cord-322899-uxvlagt3 142 1 Although although IN cord-322899-uxvlagt3 142 2 only only RB cord-322899-uxvlagt3 142 3 36 36 CD cord-322899-uxvlagt3 142 4 % % NN cord-322899-uxvlagt3 142 5 of of IN cord-322899-uxvlagt3 142 6 patients patient NNS cord-322899-uxvlagt3 142 7 infected infect VBN cord-322899-uxvlagt3 142 8 with with IN cord-322899-uxvlagt3 142 9 COVID-19 COVID-19 NNP cord-322899-uxvlagt3 142 10 in in IN cord-322899-uxvlagt3 142 11 Italy Italy NNP cord-322899-uxvlagt3 142 12 were be VBD cord-322899-uxvlagt3 142 13 over over IN cord-322899-uxvlagt3 142 14 the the DT cord-322899-uxvlagt3 142 15 age age NN cord-322899-uxvlagt3 142 16 of of IN cord-322899-uxvlagt3 142 17 70 70 CD cord-322899-uxvlagt3 142 18 , , , cord-322899-uxvlagt3 142 19 more more JJR cord-322899-uxvlagt3 142 20 than than IN cord-322899-uxvlagt3 142 21 80 80 CD cord-322899-uxvlagt3 142 22 % % NN cord-322899-uxvlagt3 142 23 of of IN cord-322899-uxvlagt3 142 24 deaths death NNS cord-322899-uxvlagt3 142 25 occurred occur VBD cord-322899-uxvlagt3 142 26 in in IN cord-322899-uxvlagt3 142 27 people people NNS cord-322899-uxvlagt3 142 28 of of IN cord-322899-uxvlagt3 142 29 this this DT cord-322899-uxvlagt3 142 30 age age NN cord-322899-uxvlagt3 142 31 . . . cord-322899-uxvlagt3 143 1 [ [ -LRB- cord-322899-uxvlagt3 143 2 113 113 CD cord-322899-uxvlagt3 143 3 ] ] -RRB- cord-322899-uxvlagt3 144 1 Furthermore furthermore RB cord-322899-uxvlagt3 144 2 , , , cord-322899-uxvlagt3 144 3 older old JJR cord-322899-uxvlagt3 144 4 adults adult NNS cord-322899-uxvlagt3 144 5 are be VBP cord-322899-uxvlagt3 144 6 more more RBR cord-322899-uxvlagt3 144 7 susceptible susceptible JJ cord-322899-uxvlagt3 144 8 to to IN cord-322899-uxvlagt3 144 9 severe severe JJ cord-322899-uxvlagt3 144 10 COVID-19 covid-19 NN cord-322899-uxvlagt3 144 11 at at IN cord-322899-uxvlagt3 144 12 admission admission NN cord-322899-uxvlagt3 144 13 . . . cord-322899-uxvlagt3 145 1 [ [ -LRB- cord-322899-uxvlagt3 145 2 114 114 CD cord-322899-uxvlagt3 145 3 ] ] -RRB- cord-322899-uxvlagt3 146 1 Immune immune JJ cord-322899-uxvlagt3 146 2 function function NN cord-322899-uxvlagt3 146 3 in in IN cord-322899-uxvlagt3 146 4 older old JJR cord-322899-uxvlagt3 146 5 adults adult NNS cord-322899-uxvlagt3 146 6 can can MD cord-322899-uxvlagt3 146 7 be be VB cord-322899-uxvlagt3 146 8 modified modify VBN cord-322899-uxvlagt3 146 9 by by IN cord-322899-uxvlagt3 146 10 nutritional nutritional JJ cord-322899-uxvlagt3 146 11 and and CC cord-322899-uxvlagt3 146 12 pharmacological pharmacological JJ cord-322899-uxvlagt3 146 13 interventions intervention NNS cord-322899-uxvlagt3 146 14 . . . cord-322899-uxvlagt3 147 1 [ [ -LRB- cord-322899-uxvlagt3 147 2 115 115 CD cord-322899-uxvlagt3 147 3 ] ] -RRB- cord-322899-uxvlagt3 147 4 Aging age VBG cord-322899-uxvlagt3 147 5 causes cause NNS cord-322899-uxvlagt3 147 6 alterations alteration NNS cord-322899-uxvlagt3 147 7 in in IN cord-322899-uxvlagt3 147 8 every every DT cord-322899-uxvlagt3 147 9 component component NN cord-322899-uxvlagt3 147 10 of of IN cord-322899-uxvlagt3 147 11 the the DT cord-322899-uxvlagt3 147 12 immune immune JJ cord-322899-uxvlagt3 147 13 system system NN cord-322899-uxvlagt3 147 14 , , , cord-322899-uxvlagt3 147 15 which which WDT cord-322899-uxvlagt3 147 16 leads lead VBZ cord-322899-uxvlagt3 147 17 to to IN cord-322899-uxvlagt3 147 18 increased increase VBN cord-322899-uxvlagt3 147 19 morbidity morbidity NN cord-322899-uxvlagt3 147 20 and and CC cord-322899-uxvlagt3 147 21 mortality mortality NN cord-322899-uxvlagt3 147 22 following follow VBG cord-322899-uxvlagt3 147 23 infectious infectious JJ cord-322899-uxvlagt3 147 24 diseases disease NNS cord-322899-uxvlagt3 147 25 . . . cord-322899-uxvlagt3 148 1 [ [ -LRB- cord-322899-uxvlagt3 148 2 116 116 CD cord-322899-uxvlagt3 148 3 , , , cord-322899-uxvlagt3 148 4 117 117 CD cord-322899-uxvlagt3 148 5 ] ] -RRB- cord-322899-uxvlagt3 149 1 The the DT cord-322899-uxvlagt3 149 2 altered altered JJ cord-322899-uxvlagt3 149 3 function function NN cord-322899-uxvlagt3 149 4 of of IN cord-322899-uxvlagt3 149 5 the the DT cord-322899-uxvlagt3 149 6 immune immune JJ cord-322899-uxvlagt3 149 7 system system NN cord-322899-uxvlagt3 149 8 in in IN cord-322899-uxvlagt3 149 9 the the DT cord-322899-uxvlagt3 149 10 elderly elderly JJ cord-322899-uxvlagt3 149 11 can can MD cord-322899-uxvlagt3 149 12 be be VB cord-322899-uxvlagt3 149 13 promoted promote VBN cord-322899-uxvlagt3 149 14 via via IN cord-322899-uxvlagt3 149 15 the the DT cord-322899-uxvlagt3 149 16 manipulation manipulation NN cord-322899-uxvlagt3 149 17 of of IN cord-322899-uxvlagt3 149 18 cytokine cytokine NN cord-322899-uxvlagt3 149 19 production production NN cord-322899-uxvlagt3 149 20 , , , cord-322899-uxvlagt3 149 21 changes change NNS cord-322899-uxvlagt3 149 22 of of IN cord-322899-uxvlagt3 149 23 metabolic metabolic JJ cord-322899-uxvlagt3 149 24 pathways pathway NNS cord-322899-uxvlagt3 149 25 in in IN cord-322899-uxvlagt3 149 26 immune immune JJ cord-322899-uxvlagt3 149 27 cells cell NNS cord-322899-uxvlagt3 149 28 , , , cord-322899-uxvlagt3 149 29 and and CC cord-322899-uxvlagt3 149 30 immune immune JJ cord-322899-uxvlagt3 149 31 - - HYPH cord-322899-uxvlagt3 149 32 system system NN cord-322899-uxvlagt3 149 33 rejuvenation rejuvenation NN cord-322899-uxvlagt3 149 34 aimed aim VBN cord-322899-uxvlagt3 149 35 at at IN cord-322899-uxvlagt3 149 36 reactivating reactivate VBG cord-322899-uxvlagt3 149 37 the the DT cord-322899-uxvlagt3 149 38 generation generation NN cord-322899-uxvlagt3 149 39 of of IN cord-322899-uxvlagt3 149 40 new new JJ cord-322899-uxvlagt3 149 41 lymphocytes lymphocyte NNS cord-322899-uxvlagt3 149 42 . . . cord-322899-uxvlagt3 150 1 [ [ -LRB- cord-322899-uxvlagt3 150 2 118 118 CD cord-322899-uxvlagt3 150 3 ] ] -RRB- cord-322899-uxvlagt3 150 4 Micronutrient Micronutrient NNP cord-322899-uxvlagt3 150 5 interventions intervention NNS cord-322899-uxvlagt3 150 6 have have VBP cord-322899-uxvlagt3 150 7 shown show VBN cord-322899-uxvlagt3 150 8 a a DT cord-322899-uxvlagt3 150 9 promising promising JJ cord-322899-uxvlagt3 150 10 impact impact NN cord-322899-uxvlagt3 150 11 in in IN cord-322899-uxvlagt3 150 12 targeting target VBG cord-322899-uxvlagt3 150 13 the the DT cord-322899-uxvlagt3 150 14 immune immune JJ cord-322899-uxvlagt3 150 15 system system NN cord-322899-uxvlagt3 150 16 impairments impairment NNS cord-322899-uxvlagt3 150 17 observed observe VBN cord-322899-uxvlagt3 150 18 in in IN cord-322899-uxvlagt3 150 19 the the DT cord-322899-uxvlagt3 150 20 elderly elderly JJ cord-322899-uxvlagt3 150 21 and and CC cord-322899-uxvlagt3 150 22 improve improve VB cord-322899-uxvlagt3 150 23 the the DT cord-322899-uxvlagt3 150 24 infection infection NN cord-322899-uxvlagt3 150 25 - - HYPH cord-322899-uxvlagt3 150 26 related relate VBN cord-322899-uxvlagt3 150 27 morbidity morbidity NN cord-322899-uxvlagt3 150 28 and and CC cord-322899-uxvlagt3 150 29 mortality mortality NN cord-322899-uxvlagt3 150 30 . . . cord-322899-uxvlagt3 151 1 [ [ -LRB- cord-322899-uxvlagt3 151 2 119 119 CD cord-322899-uxvlagt3 151 3 , , , cord-322899-uxvlagt3 151 4 120 120 CD cord-322899-uxvlagt3 151 5 ] ] -RRB- cord-322899-uxvlagt3 151 6 Micronutrient Micronutrient NNP cord-322899-uxvlagt3 151 7 deficiencies deficiency NNS cord-322899-uxvlagt3 151 8 affect affect VBP cord-322899-uxvlagt3 151 9 approximately approximately RB cord-322899-uxvlagt3 151 10 two two CD cord-322899-uxvlagt3 151 11 billion billion CD cord-322899-uxvlagt3 151 12 people people NNS cord-322899-uxvlagt3 151 13 worldwide worldwide RB cord-322899-uxvlagt3 151 14 and and CC cord-322899-uxvlagt3 151 15 contribute contribute VBP cord-322899-uxvlagt3 151 16 essentially essentially RB cord-322899-uxvlagt3 151 17 to to IN cord-322899-uxvlagt3 151 18 the the DT cord-322899-uxvlagt3 151 19 global global JJ cord-322899-uxvlagt3 151 20 burden burden NN cord-322899-uxvlagt3 151 21 of of IN cord-322899-uxvlagt3 151 22 several several JJ cord-322899-uxvlagt3 151 23 diseases disease NNS cord-322899-uxvlagt3 151 24 . . . cord-322899-uxvlagt3 152 1 [ [ -LRB- cord-322899-uxvlagt3 152 2 121 121 CD cord-322899-uxvlagt3 152 3 ] ] -RRB- cord-322899-uxvlagt3 153 1 For for IN cord-322899-uxvlagt3 153 2 instance instance NN cord-322899-uxvlagt3 153 3 , , , cord-322899-uxvlagt3 153 4 zinc zinc NN cord-322899-uxvlagt3 153 5 deficiency deficiency NN cord-322899-uxvlagt3 153 6 affects affect VBZ cord-322899-uxvlagt3 153 7 approximately approximately RB cord-322899-uxvlagt3 153 8 30 30 CD cord-322899-uxvlagt3 153 9 % % NN cord-322899-uxvlagt3 153 10 of of IN cord-322899-uxvlagt3 153 11 the the DT cord-322899-uxvlagt3 153 12 world world NN cord-322899-uxvlagt3 153 13 population population NN cord-322899-uxvlagt3 153 14 with with IN cord-322899-uxvlagt3 153 15 ranging range VBG cord-322899-uxvlagt3 153 16 from from IN cord-322899-uxvlagt3 153 17 4 4 CD cord-322899-uxvlagt3 153 18 % % NN cord-322899-uxvlagt3 153 19 to to IN cord-322899-uxvlagt3 153 20 73 73 CD cord-322899-uxvlagt3 153 21 % % NN cord-322899-uxvlagt3 153 22 across across IN cord-322899-uxvlagt3 153 23 different different JJ cord-322899-uxvlagt3 153 24 countries country NNS cord-322899-uxvlagt3 153 25 and and CC cord-322899-uxvlagt3 153 26 implicated implicate VBN cord-322899-uxvlagt3 153 27 in in IN cord-322899-uxvlagt3 153 28 about about RB cord-322899-uxvlagt3 153 29 16 16 CD cord-322899-uxvlagt3 153 30 % % NN cord-322899-uxvlagt3 153 31 of of IN cord-322899-uxvlagt3 153 32 lower low JJR cord-322899-uxvlagt3 153 33 RTI RTI NNP cord-322899-uxvlagt3 153 34 . . . cord-322899-uxvlagt3 154 1 [ [ -LRB- cord-322899-uxvlagt3 154 2 122 122 CD cord-322899-uxvlagt3 154 3 ] ] -RRB- cord-322899-uxvlagt3 154 4 Micronutrient Micronutrient NNP cord-322899-uxvlagt3 154 5 deficiencies deficiency NNS cord-322899-uxvlagt3 154 6 decrease decrease VBP cord-322899-uxvlagt3 154 7 the the DT cord-322899-uxvlagt3 154 8 ability ability NN cord-322899-uxvlagt3 154 9 to to TO cord-322899-uxvlagt3 154 10 resist resist VB cord-322899-uxvlagt3 154 11 infections infection NNS cord-322899-uxvlagt3 154 12 and and CC cord-322899-uxvlagt3 154 13 are be VBP cord-322899-uxvlagt3 154 14 common common JJ cord-322899-uxvlagt3 154 15 causes cause NNS cord-322899-uxvlagt3 154 16 of of IN cord-322899-uxvlagt3 154 17 immunodeficiency immunodeficiency NN cord-322899-uxvlagt3 154 18 in in IN cord-322899-uxvlagt3 154 19 the the DT cord-322899-uxvlagt3 154 20 developing develop VBG cord-322899-uxvlagt3 154 21 countries country NNS cord-322899-uxvlagt3 154 22 . . . cord-322899-uxvlagt3 155 1 [ [ -LRB- cord-322899-uxvlagt3 155 2 123 123 CD cord-322899-uxvlagt3 155 3 ] ] -RRB- cord-322899-uxvlagt3 156 1 Although although IN cord-322899-uxvlagt3 156 2 micronutrient micronutrient JJ cord-322899-uxvlagt3 156 3 deficiencies deficiency NNS cord-322899-uxvlagt3 156 4 are be VBP cord-322899-uxvlagt3 156 5 one one CD cord-322899-uxvlagt3 156 6 of of IN cord-322899-uxvlagt3 156 7 the the DT cord-322899-uxvlagt3 156 8 major major JJ cord-322899-uxvlagt3 156 9 public public JJ cord-322899-uxvlagt3 156 10 health health NN cord-322899-uxvlagt3 156 11 challenges challenge NNS cord-322899-uxvlagt3 156 12 in in IN cord-322899-uxvlagt3 156 13 developing develop VBG cord-322899-uxvlagt3 156 14 countries country NNS cord-322899-uxvlagt3 156 15 , , , cord-322899-uxvlagt3 156 16 about about RB cord-322899-uxvlagt3 156 17 30 30 CD cord-322899-uxvlagt3 156 18 % % NN cord-322899-uxvlagt3 156 19 of of IN cord-322899-uxvlagt3 156 20 the the DT cord-322899-uxvlagt3 156 21 population population NN cord-322899-uxvlagt3 156 22 in in IN cord-322899-uxvlagt3 156 23 industrialized industrialize VBN cord-322899-uxvlagt3 156 24 societies society NNS cord-322899-uxvlagt3 156 25 are be VBP cord-322899-uxvlagt3 156 26 also also RB cord-322899-uxvlagt3 156 27 affected affect VBN cord-322899-uxvlagt3 156 28 . . . cord-322899-uxvlagt3 157 1 [ [ -LRB- cord-322899-uxvlagt3 157 2 124 124 CD cord-322899-uxvlagt3 157 3 ] ] -RRB- cord-322899-uxvlagt3 158 1 Silent silent JJ cord-322899-uxvlagt3 158 2 epidemics epidemic NNS cord-322899-uxvlagt3 158 3 of of IN cord-322899-uxvlagt3 158 4 micronutrient micronutrient NN cord-322899-uxvlagt3 158 5 deficiencies deficiency NNS cord-322899-uxvlagt3 158 6 could could MD cord-322899-uxvlagt3 158 7 be be VB cord-322899-uxvlagt3 158 8 due due JJ cord-322899-uxvlagt3 158 9 to to IN cord-322899-uxvlagt3 158 10 insufficient insufficient JJ cord-322899-uxvlagt3 158 11 intake intake NN cord-322899-uxvlagt3 158 12 and/or and/or CC cord-322899-uxvlagt3 158 13 sufficient sufficient JJ cord-322899-uxvlagt3 158 14 intakes intake NNS cord-322899-uxvlagt3 158 15 in in IN cord-322899-uxvlagt3 158 16 association association NN cord-322899-uxvlagt3 158 17 with with IN cord-322899-uxvlagt3 158 18 impaired impaired JJ cord-322899-uxvlagt3 158 19 absorption absorption NN cord-322899-uxvlagt3 158 20 owing owe VBG cord-322899-uxvlagt3 158 21 to to IN cord-322899-uxvlagt3 158 22 infection infection NN cord-322899-uxvlagt3 158 23 , , , cord-322899-uxvlagt3 158 24 inflammation inflammation NN cord-322899-uxvlagt3 158 25 , , , cord-322899-uxvlagt3 158 26 or or CC cord-322899-uxvlagt3 158 27 chronic chronic JJ cord-322899-uxvlagt3 158 28 diseases disease NNS cord-322899-uxvlagt3 158 29 . . . cord-322899-uxvlagt3 159 1 [ [ -LRB- cord-322899-uxvlagt3 159 2 123 123 CD cord-322899-uxvlagt3 159 3 , , , cord-322899-uxvlagt3 159 4 125 125 CD cord-322899-uxvlagt3 159 5 ] ] -RRB- cord-322899-uxvlagt3 159 6 Approximately approximately RB cord-322899-uxvlagt3 159 7 35 35 CD cord-322899-uxvlagt3 159 8 % % NN cord-322899-uxvlagt3 159 9 of of IN cord-322899-uxvlagt3 159 10 populations population NNS cord-322899-uxvlagt3 159 11 who who WP cord-322899-uxvlagt3 159 12 are be VBP cord-322899-uxvlagt3 159 13 above above IN cord-322899-uxvlagt3 159 14 the the DT cord-322899-uxvlagt3 159 15 age age NN cord-322899-uxvlagt3 159 16 of of IN cord-322899-uxvlagt3 159 17 50 50 CD cord-322899-uxvlagt3 159 18 in in IN cord-322899-uxvlagt3 159 19 Europe Europe NNP cord-322899-uxvlagt3 159 20 , , , cord-322899-uxvlagt3 159 21 USA USA NNP cord-322899-uxvlagt3 159 22 , , , cord-322899-uxvlagt3 159 23 and and CC cord-322899-uxvlagt3 159 24 Canada Canada NNP cord-322899-uxvlagt3 159 25 have have VBP cord-322899-uxvlagt3 159 26 an an DT cord-322899-uxvlagt3 159 27 obvious obvious JJ cord-322899-uxvlagt3 159 28 deficiency deficiency NN cord-322899-uxvlagt3 159 29 of of IN cord-322899-uxvlagt3 159 30 one one CD cord-322899-uxvlagt3 159 31 or or CC cord-322899-uxvlagt3 159 32 more more RBR cord-322899-uxvlagt3 159 33 essential essential JJ cord-322899-uxvlagt3 159 34 micronutrients micronutrient NNS cord-322899-uxvlagt3 159 35 . . . cord-322899-uxvlagt3 160 1 [ [ -LRB- cord-322899-uxvlagt3 160 2 126 126 CD cord-322899-uxvlagt3 160 3 ] ] -RRB- cord-322899-uxvlagt3 161 1 In in IN cord-322899-uxvlagt3 161 2 addition addition NN cord-322899-uxvlagt3 161 3 to to IN cord-322899-uxvlagt3 161 4 an an DT cord-322899-uxvlagt3 161 5 insufficient insufficient JJ cord-322899-uxvlagt3 161 6 intake intake NN cord-322899-uxvlagt3 161 7 of of IN cord-322899-uxvlagt3 161 8 micronutrients micronutrient NNS cord-322899-uxvlagt3 161 9 , , , cord-322899-uxvlagt3 161 10 older old JJR cord-322899-uxvlagt3 161 11 people people NNS cord-322899-uxvlagt3 161 12 lose lose VBP cord-322899-uxvlagt3 161 13 their -PRON- PRP$ cord-322899-uxvlagt3 161 14 ability ability NN cord-322899-uxvlagt3 161 15 to to TO cord-322899-uxvlagt3 161 16 produce produce VB cord-322899-uxvlagt3 161 17 endogenous endogenous JJ cord-322899-uxvlagt3 161 18 antioxidants antioxidant NNS cord-322899-uxvlagt3 161 19 . . . cord-322899-uxvlagt3 162 1 [ [ -LRB- cord-322899-uxvlagt3 162 2 127 127 CD cord-322899-uxvlagt3 162 3 ] ] -RRB- cord-322899-uxvlagt3 162 4 Italy Italy NNP cord-322899-uxvlagt3 162 5 , , , cord-322899-uxvlagt3 162 6 Spain Spain NNP cord-322899-uxvlagt3 162 7 , , , cord-322899-uxvlagt3 162 8 and and CC cord-322899-uxvlagt3 162 9 France France NNP cord-322899-uxvlagt3 162 10 have have VBP cord-322899-uxvlagt3 162 11 experienced experience VBN cord-322899-uxvlagt3 162 12 the the DT cord-322899-uxvlagt3 162 13 highest high JJS cord-322899-uxvlagt3 162 14 COVID-19 covid-19 JJ cord-322899-uxvlagt3 162 15 death death NN cord-322899-uxvlagt3 162 16 toll toll NN cord-322899-uxvlagt3 162 17 in in IN cord-322899-uxvlagt3 162 18 Europe Europe NNP cord-322899-uxvlagt3 162 19 and and CC cord-322899-uxvlagt3 162 20 the the DT cord-322899-uxvlagt3 162 21 elderly elderly JJ cord-322899-uxvlagt3 162 22 in in IN cord-322899-uxvlagt3 162 23 these these DT cord-322899-uxvlagt3 162 24 countries country NNS cord-322899-uxvlagt3 162 25 have have VBP cord-322899-uxvlagt3 162 26 shown show VBN cord-322899-uxvlagt3 162 27 the the DT cord-322899-uxvlagt3 162 28 highest high JJS cord-322899-uxvlagt3 162 29 prevalence prevalence NN cord-322899-uxvlagt3 162 30 of of IN cord-322899-uxvlagt3 162 31 vitamin vitamin NN cord-322899-uxvlagt3 162 32 D d NN cord-322899-uxvlagt3 162 33 deficiency deficiency NN cord-322899-uxvlagt3 162 34 compared compare VBN cord-322899-uxvlagt3 162 35 with with IN cord-322899-uxvlagt3 162 36 many many JJ cord-322899-uxvlagt3 162 37 other other JJ cord-322899-uxvlagt3 162 38 European european JJ cord-322899-uxvlagt3 162 39 countries country NNS cord-322899-uxvlagt3 162 40 . . . cord-322899-uxvlagt3 163 1 [ [ -LRB- cord-322899-uxvlagt3 163 2 128 128 CD cord-322899-uxvlagt3 163 3 , , , cord-322899-uxvlagt3 163 4 129 129 CD cord-322899-uxvlagt3 163 5 ] ] -RRB- cord-322899-uxvlagt3 164 1 Approximately approximately RB cord-322899-uxvlagt3 164 2 60 60 CD cord-322899-uxvlagt3 164 3 % % NN cord-322899-uxvlagt3 164 4 of of IN cord-322899-uxvlagt3 164 5 people people NNS cord-322899-uxvlagt3 164 6 who who WP cord-322899-uxvlagt3 164 7 died die VBD cord-322899-uxvlagt3 164 8 from from IN cord-322899-uxvlagt3 164 9 COVID-19 COVID-19 NNP cord-322899-uxvlagt3 164 10 in in IN cord-322899-uxvlagt3 164 11 Italy Italy NNP cord-322899-uxvlagt3 164 12 were be VBD cord-322899-uxvlagt3 164 13 living live VBG cord-322899-uxvlagt3 164 14 in in IN cord-322899-uxvlagt3 164 15 the the DT cord-322899-uxvlagt3 164 16 Lombardy Lombardy NNP cord-322899-uxvlagt3 164 17 region region NN cord-322899-uxvlagt3 164 18 . . . cord-322899-uxvlagt3 165 1 During during IN cord-322899-uxvlagt3 165 2 the the DT cord-322899-uxvlagt3 165 3 cold cold JJ cord-322899-uxvlagt3 165 4 seasons season NNS cord-322899-uxvlagt3 165 5 , , , cord-322899-uxvlagt3 165 6 up up RB cord-322899-uxvlagt3 165 7 to to TO cord-322899-uxvlagt3 165 8 60 60 CD cord-322899-uxvlagt3 165 9 - - SYM cord-322899-uxvlagt3 165 10 90 90 CD cord-322899-uxvlagt3 165 11 % % NN cord-322899-uxvlagt3 165 12 of of IN cord-322899-uxvlagt3 165 13 the the DT cord-322899-uxvlagt3 165 14 population population NN cord-322899-uxvlagt3 165 15 in in IN cord-322899-uxvlagt3 165 16 this this DT cord-322899-uxvlagt3 165 17 region region NN cord-322899-uxvlagt3 165 18 shows show VBZ cord-322899-uxvlagt3 165 19 deficient deficient JJ cord-322899-uxvlagt3 165 20 / / SYM cord-322899-uxvlagt3 165 21 insufficient insufficient JJ cord-322899-uxvlagt3 165 22 values value NNS cord-322899-uxvlagt3 165 23 of of IN cord-322899-uxvlagt3 165 24 vitamin vitamin NN cord-322899-uxvlagt3 165 25 D. D. NNP cord-322899-uxvlagt3 165 26 [ [ -LRB- cord-322899-uxvlagt3 165 27 130 130 CD cord-322899-uxvlagt3 165 28 ] ] -RRB- cord-322899-uxvlagt3 165 29 The the DT cord-322899-uxvlagt3 165 30 Lombardy Lombardy NNP cord-322899-uxvlagt3 165 31 region region NN cord-322899-uxvlagt3 165 32 , , , cord-322899-uxvlagt3 165 33 the the DT cord-322899-uxvlagt3 165 34 most most JJS cord-322899-uxvlagt3 165 35 air air NN cord-322899-uxvlagt3 165 36 polluted polluted JJ cord-322899-uxvlagt3 165 37 area area NN cord-322899-uxvlagt3 165 38 of of IN cord-322899-uxvlagt3 165 39 Italy Italy NNP cord-322899-uxvlagt3 165 40 , , , cord-322899-uxvlagt3 165 41 has have VBZ cord-322899-uxvlagt3 165 42 a a DT cord-322899-uxvlagt3 165 43 high high JJ cord-322899-uxvlagt3 165 44 rate rate NN cord-322899-uxvlagt3 165 45 of of IN cord-322899-uxvlagt3 165 46 hospitalizations hospitalization NNS cord-322899-uxvlagt3 165 47 and and CC cord-322899-uxvlagt3 165 48 respiratory respiratory JJ cord-322899-uxvlagt3 165 49 illnesses illness NNS cord-322899-uxvlagt3 165 50 . . . cord-322899-uxvlagt3 166 1 [ [ -LRB- cord-322899-uxvlagt3 166 2 131 131 CD cord-322899-uxvlagt3 166 3 ] ] -RRB- cord-322899-uxvlagt3 167 1 Air air NN cord-322899-uxvlagt3 167 2 pollution pollution NN cord-322899-uxvlagt3 167 3 associated associate VBN cord-322899-uxvlagt3 167 4 with with IN cord-322899-uxvlagt3 167 5 increased increase VBN cord-322899-uxvlagt3 167 6 ozone ozone NN cord-322899-uxvlagt3 167 7 values value NNS cord-322899-uxvlagt3 167 8 absorbs absorb VBZ cord-322899-uxvlagt3 167 9 UVB uvb NN cord-322899-uxvlagt3 167 10 radiation radiation NN cord-322899-uxvlagt3 167 11 and and CC cord-322899-uxvlagt3 167 12 leads lead VBZ cord-322899-uxvlagt3 167 13 to to IN cord-322899-uxvlagt3 167 14 vitamin vitamin NN cord-322899-uxvlagt3 167 15 D D NNP cord-322899-uxvlagt3 167 16 deficiency deficiency NN cord-322899-uxvlagt3 167 17 . . . cord-322899-uxvlagt3 168 1 [ [ -LRB- cord-322899-uxvlagt3 168 2 132 132 CD cord-322899-uxvlagt3 168 3 ] ] -RRB- cord-322899-uxvlagt3 169 1 The the DT cord-322899-uxvlagt3 169 2 overall overall JJ cord-322899-uxvlagt3 169 3 prevalence prevalence NN cord-322899-uxvlagt3 169 4 of of IN cord-322899-uxvlagt3 169 5 low low JJ cord-322899-uxvlagt3 169 6 vitamin vitamin NN cord-322899-uxvlagt3 169 7 D d NN cord-322899-uxvlagt3 169 8 status status NN cord-322899-uxvlagt3 169 9 is be VBZ cord-322899-uxvlagt3 169 10 above above IN cord-322899-uxvlagt3 169 11 40 40 CD cord-322899-uxvlagt3 169 12 % % NN cord-322899-uxvlagt3 169 13 in in IN cord-322899-uxvlagt3 169 14 the the DT cord-322899-uxvlagt3 169 15 US US NNP cord-322899-uxvlagt3 169 16 population population NN cord-322899-uxvlagt3 169 17 . . . cord-322899-uxvlagt3 170 1 [ [ -LRB- cord-322899-uxvlagt3 170 2 133 133 CD cord-322899-uxvlagt3 170 3 ] ] -RRB- cord-322899-uxvlagt3 171 1 Several several JJ cord-322899-uxvlagt3 171 2 clinical clinical JJ cord-322899-uxvlagt3 171 3 studies study NNS cord-322899-uxvlagt3 171 4 indicate indicate VBP cord-322899-uxvlagt3 171 5 the the DT cord-322899-uxvlagt3 171 6 vital vital JJ cord-322899-uxvlagt3 171 7 role role NN cord-322899-uxvlagt3 171 8 of of IN cord-322899-uxvlagt3 171 9 micronutrients micronutrient NNS cord-322899-uxvlagt3 171 10 in in IN cord-322899-uxvlagt3 171 11 the the DT cord-322899-uxvlagt3 171 12 prevention prevention NN cord-322899-uxvlagt3 171 13 and and CC cord-322899-uxvlagt3 171 14 treatment treatment NN cord-322899-uxvlagt3 171 15 of of IN cord-322899-uxvlagt3 171 16 viral viral JJ cord-322899-uxvlagt3 171 17 infections infection NNS cord-322899-uxvlagt3 171 18 . . . cord-322899-uxvlagt3 172 1 [ [ -LRB- cord-322899-uxvlagt3 172 2 134 134 CD cord-322899-uxvlagt3 172 3 , , , cord-322899-uxvlagt3 172 4 135 135 CD cord-322899-uxvlagt3 172 5 ] ] -RRB- cord-322899-uxvlagt3 172 6 Micronutrient Micronutrient NNP cord-322899-uxvlagt3 172 7 deficiencies deficiency NNS cord-322899-uxvlagt3 172 8 , , , cord-322899-uxvlagt3 172 9 including include VBG cord-322899-uxvlagt3 172 10 zinc zinc NN cord-322899-uxvlagt3 172 11 and and CC cord-322899-uxvlagt3 172 12 vitamins vitamin NNS cord-322899-uxvlagt3 172 13 B2 b2 NN cord-322899-uxvlagt3 172 14 , , , cord-322899-uxvlagt3 172 15 B6 b6 NN cord-322899-uxvlagt3 172 16 , , , cord-322899-uxvlagt3 172 17 B12 B12 NNP cord-322899-uxvlagt3 172 18 , , , cord-322899-uxvlagt3 172 19 C C NNP cord-322899-uxvlagt3 172 20 , , , cord-322899-uxvlagt3 172 21 and and CC cord-322899-uxvlagt3 172 22 D D NNP cord-322899-uxvlagt3 172 23 , , , cord-322899-uxvlagt3 172 24 were be VBD cord-322899-uxvlagt3 172 25 reported report VBN cord-322899-uxvlagt3 172 26 to to TO cord-322899-uxvlagt3 172 27 be be VB cord-322899-uxvlagt3 172 28 common common JJ cord-322899-uxvlagt3 172 29 in in IN cord-322899-uxvlagt3 172 30 the the DT cord-322899-uxvlagt3 172 31 Ecuadorian ecuadorian JJ cord-322899-uxvlagt3 172 32 elderly elderly JJ cord-322899-uxvlagt3 172 33 , , , cord-322899-uxvlagt3 172 34 which which WDT cord-322899-uxvlagt3 172 35 weakened weaken VBD cord-322899-uxvlagt3 172 36 their -PRON- PRP$ cord-322899-uxvlagt3 172 37 immune immune JJ cord-322899-uxvlagt3 172 38 system system NN cord-322899-uxvlagt3 172 39 and and CC cord-322899-uxvlagt3 172 40 placed place VBD cord-322899-uxvlagt3 172 41 them -PRON- PRP cord-322899-uxvlagt3 172 42 at at IN cord-322899-uxvlagt3 172 43 greater great JJR cord-322899-uxvlagt3 172 44 risk risk NN cord-322899-uxvlagt3 172 45 of of IN cord-322899-uxvlagt3 172 46 viral viral JJ cord-322899-uxvlagt3 172 47 RTI RTI NNP cord-322899-uxvlagt3 172 48 . . . cord-322899-uxvlagt3 173 1 [ [ -LRB- cord-322899-uxvlagt3 173 2 74 74 CD cord-322899-uxvlagt3 173 3 ] ] -RRB- cord-322899-uxvlagt3 173 4 Administration Administration NNP cord-322899-uxvlagt3 173 5 of of IN cord-322899-uxvlagt3 173 6 Zinc Zinc NNP cord-322899-uxvlagt3 173 7 and and CC cord-322899-uxvlagt3 173 8 vitamin vitamin NN cord-322899-uxvlagt3 173 9 A a DT cord-322899-uxvlagt3 173 10 significantly significantly RB cord-322899-uxvlagt3 173 11 decreased decrease VBD cord-322899-uxvlagt3 173 12 the the DT cord-322899-uxvlagt3 173 13 incidence incidence NN cord-322899-uxvlagt3 173 14 of of IN cord-322899-uxvlagt3 173 15 pneumonia pneumonia NN cord-322899-uxvlagt3 173 16 in in IN cord-322899-uxvlagt3 173 17 children child NNS cord-322899-uxvlagt3 173 18 with with IN cord-322899-uxvlagt3 173 19 pneumonia pneumonia NN cord-322899-uxvlagt3 173 20 [ [ -LRB- cord-322899-uxvlagt3 173 21 136 136 CD cord-322899-uxvlagt3 173 22 ] ] -RRB- cord-322899-uxvlagt3 173 23 , , , cord-322899-uxvlagt3 173 24 and and CC cord-322899-uxvlagt3 173 25 oral oral JJ cord-322899-uxvlagt3 173 26 zinc zinc NN cord-322899-uxvlagt3 173 27 supplementation supplementation NN cord-322899-uxvlagt3 173 28 could could MD cord-322899-uxvlagt3 173 29 shorten shorten VB cord-322899-uxvlagt3 173 30 the the DT cord-322899-uxvlagt3 173 31 duration duration NN cord-322899-uxvlagt3 173 32 of of IN cord-322899-uxvlagt3 173 33 symptoms symptom NNS cord-322899-uxvlagt3 173 34 of of IN cord-322899-uxvlagt3 173 35 respiratory respiratory JJ cord-322899-uxvlagt3 173 36 infection infection NN cord-322899-uxvlagt3 173 37 . . . cord-322899-uxvlagt3 174 1 [ [ -LRB- cord-322899-uxvlagt3 174 2 137 137 CD cord-322899-uxvlagt3 174 3 ] ] -RRB- cord-322899-uxvlagt3 174 4 Food Food NNP cord-322899-uxvlagt3 174 5 and and CC cord-322899-uxvlagt3 174 6 Agriculture Agriculture NNP cord-322899-uxvlagt3 174 7 Organization Organization NNP cord-322899-uxvlagt3 174 8 of of IN cord-322899-uxvlagt3 174 9 the the DT cord-322899-uxvlagt3 174 10 United United NNP cord-322899-uxvlagt3 174 11 Nations Nations NNP cord-322899-uxvlagt3 174 12 has have VBZ cord-322899-uxvlagt3 174 13 reported report VBN cord-322899-uxvlagt3 174 14 that that IN cord-322899-uxvlagt3 174 15 nutrition nutrition NN cord-322899-uxvlagt3 174 16 and and CC cord-322899-uxvlagt3 174 17 antiviral antiviral JJ cord-322899-uxvlagt3 174 18 drugs drug NNS cord-322899-uxvlagt3 174 19 are be VBP cord-322899-uxvlagt3 174 20 equal equal JJ cord-322899-uxvlagt3 174 21 in in IN cord-322899-uxvlagt3 174 22 the the DT cord-322899-uxvlagt3 174 23 treatment treatment NN cord-322899-uxvlagt3 174 24 of of IN cord-322899-uxvlagt3 174 25 HIV HIV NNP cord-322899-uxvlagt3 174 26 infection infection NN cord-322899-uxvlagt3 174 27 and and CC cord-322899-uxvlagt3 174 28 regular regular JJ cord-322899-uxvlagt3 174 29 intake intake NN cord-322899-uxvlagt3 174 30 of of IN cord-322899-uxvlagt3 174 31 micronutrients micronutrient NNS cord-322899-uxvlagt3 174 32 is be VBZ cord-322899-uxvlagt3 174 33 crucial crucial JJ cord-322899-uxvlagt3 174 34 for for IN cord-322899-uxvlagt3 174 35 promoting promote VBG cord-322899-uxvlagt3 174 36 the the DT cord-322899-uxvlagt3 174 37 immune immune JJ cord-322899-uxvlagt3 174 38 response response NN cord-322899-uxvlagt3 174 39 and and CC cord-322899-uxvlagt3 174 40 maintaining maintain VBG cord-322899-uxvlagt3 174 41 good good JJ cord-322899-uxvlagt3 174 42 health health NN cord-322899-uxvlagt3 174 43 for for IN cord-322899-uxvlagt3 174 44 both both CC cord-322899-uxvlagt3 174 45 infected infected JJ cord-322899-uxvlagt3 174 46 and and CC cord-322899-uxvlagt3 174 47 uninfected uninfected JJ cord-322899-uxvlagt3 174 48 individuals individual NNS cord-322899-uxvlagt3 174 49 . . . cord-322899-uxvlagt3 175 1 [ [ -LRB- cord-322899-uxvlagt3 175 2 138 138 CD cord-322899-uxvlagt3 175 3 ] ] -RRB- cord-322899-uxvlagt3 176 1 Early early JJ cord-322899-uxvlagt3 176 2 administration administration NN cord-322899-uxvlagt3 176 3 of of IN cord-322899-uxvlagt3 176 4 vitamin vitamin NN cord-322899-uxvlagt3 176 5 A a DT cord-322899-uxvlagt3 176 6 reduced reduce VBD cord-322899-uxvlagt3 176 7 the the DT cord-322899-uxvlagt3 176 8 mortality mortality NN cord-322899-uxvlagt3 176 9 rate rate NN cord-322899-uxvlagt3 176 10 of of IN cord-322899-uxvlagt3 176 11 patients patient NNS cord-322899-uxvlagt3 176 12 with with IN cord-322899-uxvlagt3 176 13 Ebola Ebola NNP cord-322899-uxvlagt3 176 14 virus virus NN cord-322899-uxvlagt3 176 15 disease disease NN cord-322899-uxvlagt3 176 16 during during IN cord-322899-uxvlagt3 176 17 the the DT cord-322899-uxvlagt3 176 18 Western western JJ cord-322899-uxvlagt3 176 19 African african JJ cord-322899-uxvlagt3 176 20 outbreak outbreak NN cord-322899-uxvlagt3 176 21 . . . cord-322899-uxvlagt3 177 1 [ [ -LRB- cord-322899-uxvlagt3 177 2 139 139 CD cord-322899-uxvlagt3 177 3 ] ] -RRB- cord-322899-uxvlagt3 177 4 Supplementation supplementation NN cord-322899-uxvlagt3 177 5 of of IN cord-322899-uxvlagt3 177 6 micronutrients micronutrient NNS cord-322899-uxvlagt3 177 7 in in IN cord-322899-uxvlagt3 177 8 elderly elderly JJ cord-322899-uxvlagt3 177 9 subjects subject NNS cord-322899-uxvlagt3 177 10 enhanced enhance VBD cord-322899-uxvlagt3 177 11 the the DT cord-322899-uxvlagt3 177 12 number number NN cord-322899-uxvlagt3 177 13 of of IN cord-322899-uxvlagt3 177 14 T t NN cord-322899-uxvlagt3 177 15 - - HYPH cord-322899-uxvlagt3 177 16 cells cell NNS cord-322899-uxvlagt3 177 17 and and CC cord-322899-uxvlagt3 177 18 lymphocytes lymphocyte NNS cord-322899-uxvlagt3 177 19 , , , cord-322899-uxvlagt3 177 20 improved improve VBN cord-322899-uxvlagt3 177 21 lymphocyte lymphocyte NN cord-322899-uxvlagt3 177 22 response response NN cord-322899-uxvlagt3 177 23 to to IN cord-322899-uxvlagt3 177 24 mitogen mitogen NNP cord-322899-uxvlagt3 177 25 , , , cord-322899-uxvlagt3 177 26 increased increase VBN cord-322899-uxvlagt3 177 27 IL-2 IL-2 NNP cord-322899-uxvlagt3 177 28 levels level NNS cord-322899-uxvlagt3 177 29 and and CC cord-322899-uxvlagt3 177 30 NK NK NNP cord-322899-uxvlagt3 177 31 cell cell NN cord-322899-uxvlagt3 177 32 activity activity NN cord-322899-uxvlagt3 177 33 , , , cord-322899-uxvlagt3 177 34 promoted promote VBD cord-322899-uxvlagt3 177 35 the the DT cord-322899-uxvlagt3 177 36 response response NN cord-322899-uxvlagt3 177 37 to to IN cord-322899-uxvlagt3 177 38 the the DT cord-322899-uxvlagt3 177 39 influenza influenza NN cord-322899-uxvlagt3 177 40 virus virus NN cord-322899-uxvlagt3 177 41 vaccine vaccine NN cord-322899-uxvlagt3 177 42 , , , cord-322899-uxvlagt3 177 43 and and CC cord-322899-uxvlagt3 177 44 reduce reduce VB cord-322899-uxvlagt3 177 45 the the DT cord-322899-uxvlagt3 177 46 duration duration NN cord-322899-uxvlagt3 177 47 of of IN cord-322899-uxvlagt3 177 48 viral viral JJ cord-322899-uxvlagt3 177 49 diseases disease NNS cord-322899-uxvlagt3 177 50 . . . cord-322899-uxvlagt3 178 1 [ [ -LRB- cord-322899-uxvlagt3 178 2 41 41 CD cord-322899-uxvlagt3 178 3 , , , cord-322899-uxvlagt3 178 4 140 140 CD cord-322899-uxvlagt3 178 5 ] ] -RRB- cord-322899-uxvlagt3 179 1 Some some DT cord-322899-uxvlagt3 179 2 commonly commonly RB cord-322899-uxvlagt3 179 3 used use VBN cord-322899-uxvlagt3 179 4 drugs drug NNS cord-322899-uxvlagt3 179 5 , , , cord-322899-uxvlagt3 179 6 such such JJ cord-322899-uxvlagt3 179 7 as as IN cord-322899-uxvlagt3 179 8 antibiotics antibiotic NNS cord-322899-uxvlagt3 179 9 , , , cord-322899-uxvlagt3 179 10 can can MD cord-322899-uxvlagt3 179 11 lead lead VB cord-322899-uxvlagt3 179 12 to to IN cord-322899-uxvlagt3 179 13 various various JJ cord-322899-uxvlagt3 179 14 micronutrient micronutrient NN cord-322899-uxvlagt3 179 15 depletions depletion NNS cord-322899-uxvlagt3 179 16 , , , cord-322899-uxvlagt3 179 17 such such JJ cord-322899-uxvlagt3 179 18 as as IN cord-322899-uxvlagt3 179 19 iron iron NN cord-322899-uxvlagt3 179 20 and and CC cord-322899-uxvlagt3 179 21 vitamins vitamin NNS cord-322899-uxvlagt3 179 22 A A NNP cord-322899-uxvlagt3 179 23 , , , cord-322899-uxvlagt3 179 24 B b NN cord-322899-uxvlagt3 179 25 , , , cord-322899-uxvlagt3 179 26 and and CC cord-322899-uxvlagt3 179 27 D. D. NNP cord-322899-uxvlagt3 179 28 [ [ -LRB- cord-322899-uxvlagt3 179 29 141 141 CD cord-322899-uxvlagt3 179 30 ] ] -RRB- cord-322899-uxvlagt3 180 1 A a DT cord-322899-uxvlagt3 180 2 combination combination NN cord-322899-uxvlagt3 180 3 of of IN cord-322899-uxvlagt3 180 4 micronutrient micronutrient NN cord-322899-uxvlagt3 180 5 supplementation supplementation NN cord-322899-uxvlagt3 180 6 in in IN cord-322899-uxvlagt3 180 7 older old JJR cord-322899-uxvlagt3 180 8 adults adult NNS cord-322899-uxvlagt3 180 9 may may MD cord-322899-uxvlagt3 180 10 decrease decrease VB cord-322899-uxvlagt3 180 11 antibiotic antibiotic JJ cord-322899-uxvlagt3 180 12 usage usage NN cord-322899-uxvlagt3 180 13 and and CC cord-322899-uxvlagt3 180 14 causes cause VBZ cord-322899-uxvlagt3 180 15 a a DT cord-322899-uxvlagt3 180 16 higher high JJR cord-322899-uxvlagt3 180 17 post post JJ cord-322899-uxvlagt3 180 18 - - JJ cord-322899-uxvlagt3 180 19 vaccination vaccination JJ cord-322899-uxvlagt3 180 20 immune immune JJ cord-322899-uxvlagt3 180 21 response response NN cord-322899-uxvlagt3 180 22 . . . cord-322899-uxvlagt3 181 1 [ [ -LRB- cord-322899-uxvlagt3 181 2 126 126 CD cord-322899-uxvlagt3 181 3 ] ] -RRB- cord-322899-uxvlagt3 182 1 Interestingly interestingly RB cord-322899-uxvlagt3 182 2 , , , cord-322899-uxvlagt3 182 3 some some DT cord-322899-uxvlagt3 182 4 countries country NNS cord-322899-uxvlagt3 182 5 with with IN cord-322899-uxvlagt3 182 6 higher high JJR cord-322899-uxvlagt3 182 7 morbidity morbidity NN cord-322899-uxvlagt3 182 8 and and CC cord-322899-uxvlagt3 182 9 mortality mortality NN cord-322899-uxvlagt3 182 10 of of IN cord-322899-uxvlagt3 182 11 COVID-19 COVID-19 NNP cord-322899-uxvlagt3 182 12 , , , cord-322899-uxvlagt3 182 13 such such JJ cord-322899-uxvlagt3 182 14 as as IN cord-322899-uxvlagt3 182 15 Italy Italy NNP cord-322899-uxvlagt3 182 16 and and CC cord-322899-uxvlagt3 182 17 Spain Spain NNP cord-322899-uxvlagt3 182 18 , , , cord-322899-uxvlagt3 182 19 have have VBP cord-322899-uxvlagt3 182 20 a a DT cord-322899-uxvlagt3 182 21 greater great JJR cord-322899-uxvlagt3 182 22 consumption consumption NN cord-322899-uxvlagt3 182 23 of of IN cord-322899-uxvlagt3 182 24 antibiotics antibiotic NNS cord-322899-uxvlagt3 182 25 compared compare VBN cord-322899-uxvlagt3 182 26 to to IN cord-322899-uxvlagt3 182 27 other other JJ cord-322899-uxvlagt3 182 28 European european JJ cord-322899-uxvlagt3 182 29 countries country NNS cord-322899-uxvlagt3 182 30 . . . cord-322899-uxvlagt3 183 1 [ [ -LRB- cord-322899-uxvlagt3 183 2 142 142 CD cord-322899-uxvlagt3 183 3 , , , cord-322899-uxvlagt3 183 4 143 143 CD cord-322899-uxvlagt3 183 5 ] ] -RRB- cord-322899-uxvlagt3 183 6 Mice mouse NNS cord-322899-uxvlagt3 183 7 treated treat VBN cord-322899-uxvlagt3 183 8 with with IN cord-322899-uxvlagt3 183 9 antibiotics antibiotic NNS cord-322899-uxvlagt3 183 10 are be VBP cord-322899-uxvlagt3 183 11 unable unable JJ cord-322899-uxvlagt3 183 12 to to TO cord-322899-uxvlagt3 183 13 stimulate stimulate VB cord-322899-uxvlagt3 183 14 cytokine cytokine NN cord-322899-uxvlagt3 183 15 release release NN cord-322899-uxvlagt3 183 16 in in IN cord-322899-uxvlagt3 183 17 the the DT cord-322899-uxvlagt3 183 18 lung lung NN cord-322899-uxvlagt3 183 19 and and CC cord-322899-uxvlagt3 183 20 augment augment VB cord-322899-uxvlagt3 183 21 protective protective JJ cord-322899-uxvlagt3 183 22 T t NN cord-322899-uxvlagt3 183 23 - - HYPH cord-322899-uxvlagt3 183 24 cell cell NN cord-322899-uxvlagt3 183 25 responses response NNS cord-322899-uxvlagt3 183 26 following follow VBG cord-322899-uxvlagt3 183 27 influenza influenza NN cord-322899-uxvlagt3 183 28 infection infection NN cord-322899-uxvlagt3 183 29 . . . cord-322899-uxvlagt3 184 1 [ [ -LRB- cord-322899-uxvlagt3 184 2 144 144 CD cord-322899-uxvlagt3 184 3 ] ] -RRB- cord-322899-uxvlagt3 184 4 Infectious infectious JJ cord-322899-uxvlagt3 184 5 disease disease NN cord-322899-uxvlagt3 184 6 outbreaks outbreak NNS cord-322899-uxvlagt3 184 7 could could MD cord-322899-uxvlagt3 184 8 indeed indeed RB cord-322899-uxvlagt3 184 9 be be VB cord-322899-uxvlagt3 184 10 the the DT cord-322899-uxvlagt3 184 11 result result NN cord-322899-uxvlagt3 184 12 of of IN cord-322899-uxvlagt3 184 13 infection infection NN cord-322899-uxvlagt3 184 14 by by IN cord-322899-uxvlagt3 184 15 a a DT cord-322899-uxvlagt3 184 16 virus virus NN cord-322899-uxvlagt3 184 17 whose whose WP$ cord-322899-uxvlagt3 184 18 virulence virulence NN cord-322899-uxvlagt3 184 19 has have VBZ cord-322899-uxvlagt3 184 20 altered alter VBN cord-322899-uxvlagt3 184 21 as as IN cord-322899-uxvlagt3 184 22 a a DT cord-322899-uxvlagt3 184 23 result result NN cord-322899-uxvlagt3 184 24 of of IN cord-322899-uxvlagt3 184 25 replicating replicate VBG cord-322899-uxvlagt3 184 26 in in IN cord-322899-uxvlagt3 184 27 a a DT cord-322899-uxvlagt3 184 28 nutritionally nutritionally RB cord-322899-uxvlagt3 184 29 deficient deficient JJ cord-322899-uxvlagt3 184 30 host host NN cord-322899-uxvlagt3 184 31 so so IN cord-322899-uxvlagt3 184 32 that that IN cord-322899-uxvlagt3 184 33 a a DT cord-322899-uxvlagt3 184 34 non non JJ cord-322899-uxvlagt3 184 35 - - JJ cord-322899-uxvlagt3 184 36 virulent virulent JJ cord-322899-uxvlagt3 184 37 virus virus NN cord-322899-uxvlagt3 184 38 becomes become VBZ cord-322899-uxvlagt3 184 39 a a DT cord-322899-uxvlagt3 184 40 pathogen pathogen NN cord-322899-uxvlagt3 184 41 due due IN cord-322899-uxvlagt3 184 42 to to IN cord-322899-uxvlagt3 184 43 changes change NNS cord-322899-uxvlagt3 184 44 in in IN cord-322899-uxvlagt3 184 45 its -PRON- PRP$ cord-322899-uxvlagt3 184 46 genome genome NN cord-322899-uxvlagt3 184 47 . . . cord-322899-uxvlagt3 185 1 In in IN cord-322899-uxvlagt3 185 2 addition addition NN cord-322899-uxvlagt3 185 3 , , , cord-322899-uxvlagt3 185 4 available available JJ cord-322899-uxvlagt3 185 5 data datum NNS cord-322899-uxvlagt3 185 6 strongly strongly RB cord-322899-uxvlagt3 185 7 suggest suggest VBP cord-322899-uxvlagt3 185 8 that that IN cord-322899-uxvlagt3 185 9 the the DT cord-322899-uxvlagt3 185 10 association association NN cord-322899-uxvlagt3 185 11 of of IN cord-322899-uxvlagt3 185 12 unpredictable unpredictable JJ cord-322899-uxvlagt3 185 13 occurrence occurrence NN cord-322899-uxvlagt3 185 14 of of IN cord-322899-uxvlagt3 185 15 novel novel JJ cord-322899-uxvlagt3 185 16 viral viral JJ cord-322899-uxvlagt3 185 17 pathogens pathogen NNS cord-322899-uxvlagt3 185 18 combined combine VBN cord-322899-uxvlagt3 185 19 with with IN cord-322899-uxvlagt3 185 20 decreased decrease VBN cord-322899-uxvlagt3 185 21 host host NN cord-322899-uxvlagt3 185 22 immunity immunity NN cord-322899-uxvlagt3 185 23 and and CC cord-322899-uxvlagt3 185 24 micronutrient micronutrient NN cord-322899-uxvlagt3 185 25 deficiency deficiency NN cord-322899-uxvlagt3 185 26 poses pose VBZ cord-322899-uxvlagt3 185 27 a a DT cord-322899-uxvlagt3 185 28 twofold twofold JJ cord-322899-uxvlagt3 185 29 threat threat NN cord-322899-uxvlagt3 185 30 to to IN cord-322899-uxvlagt3 185 31 human human JJ cord-322899-uxvlagt3 185 32 health health NN cord-322899-uxvlagt3 185 33 in in IN cord-322899-uxvlagt3 185 34 the the DT cord-322899-uxvlagt3 185 35 near near JJ cord-322899-uxvlagt3 185 36 future future NN cord-322899-uxvlagt3 185 37 . . . cord-322899-uxvlagt3 186 1 Further further RB cord-322899-uxvlagt3 186 2 investigating investigate VBG cord-322899-uxvlagt3 186 3 the the DT cord-322899-uxvlagt3 186 4 role role NN cord-322899-uxvlagt3 186 5 of of IN cord-322899-uxvlagt3 186 6 micronutrients micronutrient NNS cord-322899-uxvlagt3 186 7 and and CC cord-322899-uxvlagt3 186 8 their -PRON- PRP$ cord-322899-uxvlagt3 186 9 substitution substitution NN cord-322899-uxvlagt3 186 10 on on IN cord-322899-uxvlagt3 186 11 immune immune JJ cord-322899-uxvlagt3 186 12 system system NN cord-322899-uxvlagt3 186 13 activity activity NN cord-322899-uxvlagt3 186 14 , , , cord-322899-uxvlagt3 186 15 therefore therefore RB cord-322899-uxvlagt3 186 16 , , , cord-322899-uxvlagt3 186 17 may may MD cord-322899-uxvlagt3 186 18 present present VB cord-322899-uxvlagt3 186 19 a a DT cord-322899-uxvlagt3 186 20 highly highly RB cord-322899-uxvlagt3 186 21 cost cost NN cord-322899-uxvlagt3 186 22 - - HYPH cord-322899-uxvlagt3 186 23 efficient efficient JJ cord-322899-uxvlagt3 186 24 and and CC cord-322899-uxvlagt3 186 25 uncomplicated uncomplicated JJ cord-322899-uxvlagt3 186 26 measure measure NN cord-322899-uxvlagt3 186 27 with with IN cord-322899-uxvlagt3 186 28 promising promising JJ cord-322899-uxvlagt3 186 29 long long JJ cord-322899-uxvlagt3 186 30 - - HYPH cord-322899-uxvlagt3 186 31 term term NN cord-322899-uxvlagt3 186 32 benefits benefit NNS cord-322899-uxvlagt3 186 33 on on IN cord-322899-uxvlagt3 186 34 future future JJ cord-322899-uxvlagt3 186 35 viral viral JJ cord-322899-uxvlagt3 186 36 outbreaks outbreak NNS cord-322899-uxvlagt3 186 37 . . . cord-322899-uxvlagt3 187 1 The the DT cord-322899-uxvlagt3 187 2 development development NN cord-322899-uxvlagt3 187 3 of of IN cord-322899-uxvlagt3 187 4 novel novel JJ cord-322899-uxvlagt3 187 5 vaccinations vaccination NNS cord-322899-uxvlagt3 187 6 and and CC cord-322899-uxvlagt3 187 7 drugs drug NNS cord-322899-uxvlagt3 187 8 targeting target VBG cord-322899-uxvlagt3 187 9 pathogens pathogen NNS cord-322899-uxvlagt3 187 10 that that WDT cord-322899-uxvlagt3 187 11 cause cause VBP cord-322899-uxvlagt3 187 12 currently currently RB cord-322899-uxvlagt3 187 13 relevant relevant JJ cord-322899-uxvlagt3 187 14 diseases disease NNS cord-322899-uxvlagt3 187 15 is be VBZ cord-322899-uxvlagt3 187 16 often often RB cord-322899-uxvlagt3 187 17 an an DT cord-322899-uxvlagt3 187 18 expensive expensive JJ cord-322899-uxvlagt3 187 19 and and CC cord-322899-uxvlagt3 187 20 risky risky JJ cord-322899-uxvlagt3 187 21 process process NN cord-322899-uxvlagt3 187 22 associated associate VBN cord-322899-uxvlagt3 187 23 with with IN cord-322899-uxvlagt3 187 24 a a DT cord-322899-uxvlagt3 187 25 narrow narrow JJ cord-322899-uxvlagt3 187 26 spectrum spectrum NN cord-322899-uxvlagt3 187 27 efficacy efficacy NN cord-322899-uxvlagt3 187 28 due due IN cord-322899-uxvlagt3 187 29 to to IN cord-322899-uxvlagt3 187 30 their -PRON- PRP$ cord-322899-uxvlagt3 187 31 selective selective JJ cord-322899-uxvlagt3 187 32 applications application NNS cord-322899-uxvlagt3 187 33 . . . cord-322899-uxvlagt3 188 1 Furthermore furthermore RB cord-322899-uxvlagt3 188 2 , , , cord-322899-uxvlagt3 188 3 the the DT cord-322899-uxvlagt3 188 4 use use NN cord-322899-uxvlagt3 188 5 of of IN cord-322899-uxvlagt3 188 6 novel novel JJ cord-322899-uxvlagt3 188 7 vaccines vaccine NNS cord-322899-uxvlagt3 188 8 and and CC cord-322899-uxvlagt3 188 9 drugs drug NNS cord-322899-uxvlagt3 188 10 is be VBZ cord-322899-uxvlagt3 188 11 usually usually RB cord-322899-uxvlagt3 188 12 restricted restrict VBN cord-322899-uxvlagt3 188 13 to to IN cord-322899-uxvlagt3 188 14 the the DT cord-322899-uxvlagt3 188 15 global global JJ cord-322899-uxvlagt3 188 16 population population NN cord-322899-uxvlagt3 188 17 due due IN cord-322899-uxvlagt3 188 18 to to IN cord-322899-uxvlagt3 188 19 their -PRON- PRP$ cord-322899-uxvlagt3 188 20 high high JJ cord-322899-uxvlagt3 188 21 costs cost NNS cord-322899-uxvlagt3 188 22 . . . cord-322899-uxvlagt3 189 1 A a DT cord-322899-uxvlagt3 189 2 decade decade NN cord-322899-uxvlagt3 189 3 ago ago RB cord-322899-uxvlagt3 189 4 , , , cord-322899-uxvlagt3 189 5 the the DT cord-322899-uxvlagt3 189 6 Copenhagen Copenhagen NNP cord-322899-uxvlagt3 189 7 Consensus Consensus NNP cord-322899-uxvlagt3 189 8 project project NN cord-322899-uxvlagt3 189 9 on on IN cord-322899-uxvlagt3 189 10 hunger hunger NN cord-322899-uxvlagt3 189 11 and and CC cord-322899-uxvlagt3 189 12 malnutrition malnutrition NN cord-322899-uxvlagt3 189 13 concluded conclude VBD cord-322899-uxvlagt3 189 14 that that IN cord-322899-uxvlagt3 189 15 efforts effort NNS cord-322899-uxvlagt3 189 16 to to TO cord-322899-uxvlagt3 189 17 provide provide VB cord-322899-uxvlagt3 189 18 micronutrients micronutrient NNS cord-322899-uxvlagt3 189 19 for for IN cord-322899-uxvlagt3 189 20 the the DT cord-322899-uxvlagt3 189 21 global global JJ cord-322899-uxvlagt3 189 22 population population NN cord-322899-uxvlagt3 189 23 generate generate VBP cord-322899-uxvlagt3 189 24 higher high JJR cord-322899-uxvlagt3 189 25 returns return NNS cord-322899-uxvlagt3 189 26 than than IN cord-322899-uxvlagt3 189 27 any any DT cord-322899-uxvlagt3 189 28 other other JJ cord-322899-uxvlagt3 189 29 public public JJ cord-322899-uxvlagt3 189 30 health health NN cord-322899-uxvlagt3 189 31 measure measure NN cord-322899-uxvlagt3 189 32 . . . cord-322899-uxvlagt3 190 1 [ [ -LRB- cord-322899-uxvlagt3 190 2 147 147 CD cord-322899-uxvlagt3 190 3 ] ] -RRB- cord-322899-uxvlagt3 191 1 There there EX cord-322899-uxvlagt3 191 2 is be VBZ cord-322899-uxvlagt3 191 3 no no DT cord-322899-uxvlagt3 191 4 conflict conflict NN cord-322899-uxvlagt3 191 5 of of IN cord-322899-uxvlagt3 191 6 interest interest NN cord-322899-uxvlagt3 191 7 . . . cord-322899-uxvlagt3 192 1 The the DT cord-322899-uxvlagt3 192 2 authors author NNS cord-322899-uxvlagt3 192 3 received receive VBD cord-322899-uxvlagt3 192 4 no no DT cord-322899-uxvlagt3 192 5 financial financial JJ cord-322899-uxvlagt3 192 6 support support NN cord-322899-uxvlagt3 192 7 for for IN cord-322899-uxvlagt3 192 8 this this DT cord-322899-uxvlagt3 192 9 study study NN cord-322899-uxvlagt3 192 10 . . . cord-322899-uxvlagt3 192 11 _SP cord-322899-uxvlagt3 193 1 10 10 CD cord-322899-uxvlagt3 193 2 Years year NNS cord-322899-uxvlagt3 193 3 on on RB cord-322899-uxvlagt3 193 4 , , , cord-322899-uxvlagt3 193 5 the the DT cord-322899-uxvlagt3 193 6 world world NN cord-322899-uxvlagt3 193 7 still still RB cord-322899-uxvlagt3 193 8 learns learn VBZ cord-322899-uxvlagt3 193 9 from from IN cord-322899-uxvlagt3 193 10 SARS SARS NNP cord-322899-uxvlagt3 193 11 Transmission Transmission NNP cord-322899-uxvlagt3 193 12 routes route NNS cord-322899-uxvlagt3 193 13 of of IN cord-322899-uxvlagt3 193 14 2019-nCoV 2019-ncov CD cord-322899-uxvlagt3 193 15 and and CC cord-322899-uxvlagt3 193 16 controls control NNS cord-322899-uxvlagt3 193 17 in in IN cord-322899-uxvlagt3 193 18 dental dental JJ cord-322899-uxvlagt3 193 19 practice practice NN cord-322899-uxvlagt3 193 20 Coronavirus Coronavirus NNP cord-322899-uxvlagt3 193 21 infections infection NNS cord-322899-uxvlagt3 193 22 and and CC cord-322899-uxvlagt3 193 23 immune immune JJ cord-322899-uxvlagt3 193 24 responses response NNS cord-322899-uxvlagt3 194 1 Molecular molecular JJ cord-322899-uxvlagt3 194 2 pathology pathology NN cord-322899-uxvlagt3 194 3 of of IN cord-322899-uxvlagt3 194 4 emerging emerge VBG cord-322899-uxvlagt3 194 5 coronavirus coronavirus NN cord-322899-uxvlagt3 194 6 infections infection NNS cord-322899-uxvlagt3 194 7 Micronutrients micronutrient NNS cord-322899-uxvlagt3 194 8 and and CC cord-322899-uxvlagt3 194 9 host host NN cord-322899-uxvlagt3 194 10 resistance resistance NN cord-322899-uxvlagt3 194 11 to to IN cord-322899-uxvlagt3 194 12 viral viral JJ cord-322899-uxvlagt3 194 13 infection infection NN cord-322899-uxvlagt3 194 14 Increased increase VBN cord-322899-uxvlagt3 194 15 virulence virulence NN cord-322899-uxvlagt3 194 16 of of IN cord-322899-uxvlagt3 194 17 coxsackievirus coxsackievirus NNP cord-322899-uxvlagt3 194 18 B3 b3 NN cord-322899-uxvlagt3 194 19 in in IN cord-322899-uxvlagt3 194 20 mice mouse NNS cord-322899-uxvlagt3 194 21 due due JJ cord-322899-uxvlagt3 194 22 to to IN cord-322899-uxvlagt3 194 23 vitamin vitamin NN cord-322899-uxvlagt3 194 24 E e NN cord-322899-uxvlagt3 194 25 or or CC cord-322899-uxvlagt3 194 26 selenium selenium NN cord-322899-uxvlagt3 194 27 deficiency deficiency NN cord-322899-uxvlagt3 195 1 Host host JJ cord-322899-uxvlagt3 195 2 nutritional nutritional JJ cord-322899-uxvlagt3 195 3 status status NN cord-322899-uxvlagt3 195 4 and and CC cord-322899-uxvlagt3 195 5 its -PRON- PRP$ cord-322899-uxvlagt3 195 6 effect effect NN cord-322899-uxvlagt3 195 7 on on IN cord-322899-uxvlagt3 195 8 a a DT cord-322899-uxvlagt3 195 9 viral viral JJ cord-322899-uxvlagt3 195 10 pathogen pathogen NN cord-322899-uxvlagt3 195 11 Breadth Breadth NNP cord-322899-uxvlagt3 195 12 of of IN cord-322899-uxvlagt3 195 13 concomitant concomitant JJ cord-322899-uxvlagt3 195 14 immune immune JJ cord-322899-uxvlagt3 195 15 responses response NNS cord-322899-uxvlagt3 195 16 prior prior RB cord-322899-uxvlagt3 195 17 to to IN cord-322899-uxvlagt3 195 18 patient patient NN cord-322899-uxvlagt3 195 19 recovery recovery NN cord-322899-uxvlagt3 195 20 : : : cord-322899-uxvlagt3 196 1 a a DT cord-322899-uxvlagt3 196 2 case case NN cord-322899-uxvlagt3 196 3 report report NN cord-322899-uxvlagt3 196 4 of of IN cord-322899-uxvlagt3 196 5 non non JJ cord-322899-uxvlagt3 196 6 - - JJ cord-322899-uxvlagt3 196 7 severe severe JJ cord-322899-uxvlagt3 196 8 COVID-19 COVID-19 NNP cord-322899-uxvlagt3 196 9 Clinical clinical JJ cord-322899-uxvlagt3 196 10 features feature NNS cord-322899-uxvlagt3 196 11 of of IN cord-322899-uxvlagt3 196 12 patients patient NNS cord-322899-uxvlagt3 196 13 infected infect VBN cord-322899-uxvlagt3 196 14 with with IN cord-322899-uxvlagt3 196 15 2019 2019 CD cord-322899-uxvlagt3 196 16 novel novel JJ cord-322899-uxvlagt3 196 17 coronavirus coronavirus NN cord-322899-uxvlagt3 196 18 in in IN cord-322899-uxvlagt3 196 19 Wuhan Wuhan NNP cord-322899-uxvlagt3 196 20 , , , cord-322899-uxvlagt3 196 21 China China NNP cord-322899-uxvlagt3 196 22 Clinical Clinical NNP cord-322899-uxvlagt3 196 23 Features Features NNPS cord-322899-uxvlagt3 196 24 of of IN cord-322899-uxvlagt3 196 25 69 69 CD cord-322899-uxvlagt3 196 26 Cases case NNS cord-322899-uxvlagt3 196 27 with with IN cord-322899-uxvlagt3 196 28 Coronavirus Coronavirus NNP cord-322899-uxvlagt3 196 29 Disease Disease NNP cord-322899-uxvlagt3 196 30 Expression expression NN cord-322899-uxvlagt3 196 31 of of IN cord-322899-uxvlagt3 196 32 elevated elevated JJ cord-322899-uxvlagt3 196 33 levels level NNS cord-322899-uxvlagt3 196 34 of of IN cord-322899-uxvlagt3 196 35 proinflammatory proinflammatory JJ cord-322899-uxvlagt3 196 36 cytokines cytokine NNS cord-322899-uxvlagt3 196 37 in in IN cord-322899-uxvlagt3 196 38 SARS SARS NNP cord-322899-uxvlagt3 196 39 - - HYPH cord-322899-uxvlagt3 196 40 CoV CoV NNP cord-322899-uxvlagt3 196 41 - - HYPH cord-322899-uxvlagt3 196 42 infected infect VBN cord-322899-uxvlagt3 196 43 ACE2 ACE2 NNP cord-322899-uxvlagt3 196 44 + + CC cord-322899-uxvlagt3 196 45 cells cell NNS cord-322899-uxvlagt3 196 46 in in IN cord-322899-uxvlagt3 196 47 SARS SARS NNP cord-322899-uxvlagt3 196 48 patients patient NNS cord-322899-uxvlagt3 196 49 : : : cord-322899-uxvlagt3 196 50 relation relation NN cord-322899-uxvlagt3 196 51 to to IN cord-322899-uxvlagt3 196 52 the the DT cord-322899-uxvlagt3 196 53 acute acute JJ cord-322899-uxvlagt3 196 54 lung lung NN cord-322899-uxvlagt3 196 55 injury injury NN cord-322899-uxvlagt3 196 56 and and CC cord-322899-uxvlagt3 196 57 pathogenesis pathogenesis NN cord-322899-uxvlagt3 196 58 of of IN cord-322899-uxvlagt3 196 59 SARS SARS NNP cord-322899-uxvlagt3 196 60 Platelet Platelet NNP cord-322899-uxvlagt3 196 61 - - HYPH cord-322899-uxvlagt3 196 62 to to IN cord-322899-uxvlagt3 196 63 - - HYPH cord-322899-uxvlagt3 196 64 lymphocyte lymphocyte NN cord-322899-uxvlagt3 196 65 ratio ratio NN cord-322899-uxvlagt3 196 66 is be VBZ cord-322899-uxvlagt3 196 67 associated associate VBN cord-322899-uxvlagt3 196 68 with with IN cord-322899-uxvlagt3 196 69 prognosis prognosis NN cord-322899-uxvlagt3 196 70 in in IN cord-322899-uxvlagt3 196 71 patients patient NNS cord-322899-uxvlagt3 196 72 with with IN cord-322899-uxvlagt3 196 73 Corona Corona NNP cord-322899-uxvlagt3 196 74 Virus Virus NNP cord-322899-uxvlagt3 196 75 Disease-19 Disease-19 NNP cord-322899-uxvlagt3 196 76 Clinical clinical JJ cord-322899-uxvlagt3 196 77 course course NN cord-322899-uxvlagt3 196 78 and and CC cord-322899-uxvlagt3 196 79 risk risk NN cord-322899-uxvlagt3 196 80 factors factor NNS cord-322899-uxvlagt3 196 81 for for IN cord-322899-uxvlagt3 196 82 mortality mortality NN cord-322899-uxvlagt3 196 83 of of IN cord-322899-uxvlagt3 196 84 adult adult NN cord-322899-uxvlagt3 196 85 inpatients inpatient NNS cord-322899-uxvlagt3 196 86 with with IN cord-322899-uxvlagt3 196 87 COVID-19 COVID-19 NNP cord-322899-uxvlagt3 196 88 in in IN cord-322899-uxvlagt3 196 89 Wuhan Wuhan NNP cord-322899-uxvlagt3 196 90 , , , cord-322899-uxvlagt3 196 91 China China NNP cord-322899-uxvlagt3 196 92 : : : cord-322899-uxvlagt3 197 1 a a DT cord-322899-uxvlagt3 197 2 retrospective retrospective JJ cord-322899-uxvlagt3 197 3 cohort cohort NN cord-322899-uxvlagt3 197 4 study study NN cord-322899-uxvlagt3 197 5 Zinc Zinc NNP cord-322899-uxvlagt3 197 6 in in IN cord-322899-uxvlagt3 197 7 Infection Infection NNP cord-322899-uxvlagt3 197 8 and and CC cord-322899-uxvlagt3 197 9 Inflammation Inflammation NNP cord-322899-uxvlagt3 197 10 Antioxidant Antioxidant NNP cord-322899-uxvlagt3 197 11 and and CC cord-322899-uxvlagt3 197 12 anti anti JJ cord-322899-uxvlagt3 197 13 - - JJ cord-322899-uxvlagt3 197 14 inflammatory inflammatory JJ cord-322899-uxvlagt3 197 15 effects effect NNS cord-322899-uxvlagt3 197 16 of of IN cord-322899-uxvlagt3 197 17 zinc zinc NN cord-322899-uxvlagt3 197 18 . . . cord-322899-uxvlagt3 198 1 Zinc zinc NN cord-322899-uxvlagt3 198 2 - - HYPH cord-322899-uxvlagt3 198 3 dependent dependent JJ cord-322899-uxvlagt3 198 4 NF nf NN cord-322899-uxvlagt3 198 5 - - HYPH cord-322899-uxvlagt3 198 6 κB κB NNP cord-322899-uxvlagt3 198 7 signaling signal VBG cord-322899-uxvlagt3 198 8 The the DT cord-322899-uxvlagt3 198 9 Role role NN cord-322899-uxvlagt3 198 10 of of IN cord-322899-uxvlagt3 198 11 Zinc Zinc NNP cord-322899-uxvlagt3 198 12 in in IN cord-322899-uxvlagt3 198 13 Antiviral Antiviral NNP cord-322899-uxvlagt3 198 14 Immunity Immunity NNP cord-322899-uxvlagt3 198 15 Serum Serum NNP cord-322899-uxvlagt3 198 16 zinc zinc NN cord-322899-uxvlagt3 198 17 and and CC cord-322899-uxvlagt3 198 18 pneumonia pneumonia NN cord-322899-uxvlagt3 198 19 in in IN cord-322899-uxvlagt3 198 20 nursing nursing NN cord-322899-uxvlagt3 198 21 home home NN cord-322899-uxvlagt3 198 22 elderly elderly JJ cord-322899-uxvlagt3 198 23 Nsp3 Nsp3 NNS cord-322899-uxvlagt3 198 24 of of IN cord-322899-uxvlagt3 198 25 coronaviruses coronaviruse NNS cord-322899-uxvlagt3 198 26 : : : cord-322899-uxvlagt3 198 27 Structures structure NNS cord-322899-uxvlagt3 198 28 and and CC cord-322899-uxvlagt3 198 29 functions function NNS cord-322899-uxvlagt3 198 30 of of IN cord-322899-uxvlagt3 198 31 a a DT cord-322899-uxvlagt3 198 32 large large JJ cord-322899-uxvlagt3 198 33 multi multi JJ cord-322899-uxvlagt3 198 34 - - JJ cord-322899-uxvlagt3 198 35 domain domain NN cord-322899-uxvlagt3 198 36 protein protein NN cord-322899-uxvlagt3 198 37 Structural structural JJ cord-322899-uxvlagt3 198 38 basis basis NN cord-322899-uxvlagt3 198 39 and and CC cord-322899-uxvlagt3 198 40 functional functional JJ cord-322899-uxvlagt3 198 41 analysis analysis NN cord-322899-uxvlagt3 198 42 of of IN cord-322899-uxvlagt3 198 43 the the DT cord-322899-uxvlagt3 198 44 SARS SARS NNP cord-322899-uxvlagt3 198 45 coronavirus coronavirus NN cord-322899-uxvlagt3 198 46 nsp14-nsp10 nsp14-nsp10 JJ cord-322899-uxvlagt3 198 47 complex complex JJ cord-322899-uxvlagt3 198 48 Mutagenesis Mutagenesis NNP cord-322899-uxvlagt3 198 49 of of IN cord-322899-uxvlagt3 198 50 Coronavirus Coronavirus NNP cord-322899-uxvlagt3 199 1 nsp14 nsp14 NNP cord-322899-uxvlagt3 199 2 Reveals reveal VBZ cord-322899-uxvlagt3 199 3 Its -PRON- PRP$ cord-322899-uxvlagt3 199 4 Potential potential JJ cord-322899-uxvlagt3 199 5 Role role NN cord-322899-uxvlagt3 199 6 in in IN cord-322899-uxvlagt3 199 7 Modulation modulation NN cord-322899-uxvlagt3 199 8 of of IN cord-322899-uxvlagt3 199 9 the the DT cord-322899-uxvlagt3 199 10 Innate Innate NNP cord-322899-uxvlagt3 199 11 Immune Immune NNP cord-322899-uxvlagt3 199 12 Response Response NNP cord-322899-uxvlagt3 199 13 Crystal Crystal NNP cord-322899-uxvlagt3 199 14 structure structure NN cord-322899-uxvlagt3 199 15 of of IN cord-322899-uxvlagt3 199 16 Middle Middle NNP cord-322899-uxvlagt3 199 17 East East NNP cord-322899-uxvlagt3 199 18 respiratory respiratory JJ cord-322899-uxvlagt3 199 19 syndrome syndrome NN cord-322899-uxvlagt3 199 20 coronavirus coronavirus NN cord-322899-uxvlagt3 199 21 helicase helicase NN cord-322899-uxvlagt3 199 22 Differential differential JJ cord-322899-uxvlagt3 199 23 domain domain NN cord-322899-uxvlagt3 199 24 structure structure NN cord-322899-uxvlagt3 199 25 stability stability NN cord-322899-uxvlagt3 199 26 of of IN cord-322899-uxvlagt3 199 27 the the DT cord-322899-uxvlagt3 199 28 severe severe JJ cord-322899-uxvlagt3 199 29 acute acute JJ cord-322899-uxvlagt3 199 30 respiratory respiratory JJ cord-322899-uxvlagt3 199 31 syndrome syndrome NN cord-322899-uxvlagt3 199 32 coronavirus coronavirus NN cord-322899-uxvlagt3 199 33 papain papain NN cord-322899-uxvlagt3 199 34 - - HYPH cord-322899-uxvlagt3 199 35 like like JJ cord-322899-uxvlagt3 199 36 protease protease NN cord-322899-uxvlagt3 199 37 Host host NN cord-322899-uxvlagt3 199 38 nutritional nutritional JJ cord-322899-uxvlagt3 199 39 status status NN cord-322899-uxvlagt3 199 40 : : : cord-322899-uxvlagt3 199 41 the the DT cord-322899-uxvlagt3 199 42 neglected neglect VBN cord-322899-uxvlagt3 199 43 virulence virulence NN cord-322899-uxvlagt3 199 44 factor factor NN cord-322899-uxvlagt3 199 45 A a DT cord-322899-uxvlagt3 199 46 Role role NN cord-322899-uxvlagt3 199 47 for for IN cord-322899-uxvlagt3 199 48 Iodide Iodide NNP cord-322899-uxvlagt3 199 49 and and CC cord-322899-uxvlagt3 199 50 Thyroglobulin Thyroglobulin NNP cord-322899-uxvlagt3 199 51 in in IN cord-322899-uxvlagt3 199 52 Modulating modulate VBG cord-322899-uxvlagt3 199 53 the the DT cord-322899-uxvlagt3 199 54 Function Function NNP cord-322899-uxvlagt3 199 55 of of IN cord-322899-uxvlagt3 199 56 Human Human NNP cord-322899-uxvlagt3 199 57 Immune Immune NNP cord-322899-uxvlagt3 199 58 Cells Cells NNPS cord-322899-uxvlagt3 199 59 Extrathyroidal Extrathyroidal NNP cord-322899-uxvlagt3 199 60 iodide iodide NN cord-322899-uxvlagt3 199 61 concentrating concentrate VBG cord-322899-uxvlagt3 199 62 mechanisms mechanism NNS cord-322899-uxvlagt3 200 1 The the DT cord-322899-uxvlagt3 200 2 Na+/I Na+/I NNP cord-322899-uxvlagt3 200 3 - - HYPH cord-322899-uxvlagt3 200 4 symporter symporter NN cord-322899-uxvlagt3 200 5 ( ( -LRB- cord-322899-uxvlagt3 200 6 NIS NIS NNP cord-322899-uxvlagt3 200 7 ) ) -RRB- cord-322899-uxvlagt3 200 8 : : : cord-322899-uxvlagt3 200 9 mechanism mechanism NN cord-322899-uxvlagt3 200 10 and and CC cord-322899-uxvlagt3 200 11 medical medical JJ cord-322899-uxvlagt3 200 12 impact impact NN cord-322899-uxvlagt3 200 13 Enhancement enhancement NN cord-322899-uxvlagt3 200 14 of of IN cord-322899-uxvlagt3 200 15 respiratory respiratory JJ cord-322899-uxvlagt3 200 16 mucosal mucosal JJ cord-322899-uxvlagt3 200 17 antiviral antiviral JJ cord-322899-uxvlagt3 200 18 defenses defense NNS cord-322899-uxvlagt3 200 19 by by IN cord-322899-uxvlagt3 200 20 the the DT cord-322899-uxvlagt3 200 21 oxidation oxidation NN cord-322899-uxvlagt3 200 22 of of IN cord-322899-uxvlagt3 200 23 iodide iodide NN cord-322899-uxvlagt3 201 1 In in IN cord-322899-uxvlagt3 201 2 Vitro Vitro NNP cord-322899-uxvlagt3 201 3 Bactericidal Bactericidal NNP cord-322899-uxvlagt3 201 4 and and CC cord-322899-uxvlagt3 201 5 Virucidal Virucidal NNP cord-322899-uxvlagt3 201 6 Efficacy Efficacy NNP cord-322899-uxvlagt3 201 7 of of IN cord-322899-uxvlagt3 201 8 Povidone Povidone NNP cord-322899-uxvlagt3 201 9 - - HYPH cord-322899-uxvlagt3 201 10 Iodine iodine NN cord-322899-uxvlagt3 201 11 Gargle Gargle NNP cord-322899-uxvlagt3 201 12 / / SYM cord-322899-uxvlagt3 201 13 Mouthwash Mouthwash NNP cord-322899-uxvlagt3 201 14 Against against IN cord-322899-uxvlagt3 201 15 Respiratory Respiratory NNP cord-322899-uxvlagt3 201 16 and and CC cord-322899-uxvlagt3 201 17 Oral oral JJ cord-322899-uxvlagt3 201 18 Tract tract NN cord-322899-uxvlagt3 201 19 Pathogens Pathogens NNPS cord-322899-uxvlagt3 201 20 Immune Immune NNP cord-322899-uxvlagt3 201 21 function function NN cord-322899-uxvlagt3 201 22 and and CC cord-322899-uxvlagt3 201 23 micronutrient micronutrient NN cord-322899-uxvlagt3 201 24 requirements requirement NNS cord-322899-uxvlagt3 201 25 change change VBP cord-322899-uxvlagt3 201 26 over over IN cord-322899-uxvlagt3 202 1 the the DT cord-322899-uxvlagt3 202 2 life life NN cord-322899-uxvlagt3 202 3 course course NN cord-322899-uxvlagt3 203 1 A a DT cord-322899-uxvlagt3 203 2 Review Review NNP cord-322899-uxvlagt3 203 3 of of IN cord-322899-uxvlagt3 203 4 Micronutrients micronutrient NNS cord-322899-uxvlagt3 203 5 and and CC cord-322899-uxvlagt3 203 6 the the DT cord-322899-uxvlagt3 203 7 Immune Immune NNP cord-322899-uxvlagt3 203 8 System- System- NNP cord-322899-uxvlagt3 204 1 Working work VBG cord-322899-uxvlagt3 204 2 in in IN cord-322899-uxvlagt3 204 3 Harmony Harmony NNP cord-322899-uxvlagt3 204 4 to to TO cord-322899-uxvlagt3 204 5 Reduce reduce VB cord-322899-uxvlagt3 204 6 the the DT cord-322899-uxvlagt3 204 7 Risk risk NN cord-322899-uxvlagt3 204 8 of of IN cord-322899-uxvlagt3 204 9 Infection Infection NNP cord-322899-uxvlagt3 204 10 Copper Copper NNP cord-322899-uxvlagt3 204 11 and and CC cord-322899-uxvlagt3 204 12 immunity immunity NN cord-322899-uxvlagt3 204 13 Deactivation deactivation NN cord-322899-uxvlagt3 204 14 of of IN cord-322899-uxvlagt3 204 15 human human JJ cord-322899-uxvlagt3 204 16 immunodeficiency immunodeficiency NN cord-322899-uxvlagt3 204 17 virus virus NN cord-322899-uxvlagt3 204 18 type type NN cord-322899-uxvlagt3 204 19 1 1 CD cord-322899-uxvlagt3 204 20 in in IN cord-322899-uxvlagt3 204 21 medium medium NN cord-322899-uxvlagt3 204 22 by by IN cord-322899-uxvlagt3 204 23 copper copper NN cord-322899-uxvlagt3 204 24 oxide oxide NN cord-322899-uxvlagt3 204 25 - - HYPH cord-322899-uxvlagt3 204 26 containing contain VBG cord-322899-uxvlagt3 204 27 filters filter NNS cord-322899-uxvlagt3 205 1 The the DT cord-322899-uxvlagt3 205 2 Yin Yin NNP cord-322899-uxvlagt3 205 3 and and CC cord-322899-uxvlagt3 205 4 Yang Yang NNP cord-322899-uxvlagt3 205 5 of of IN cord-322899-uxvlagt3 205 6 copper copper NN cord-322899-uxvlagt3 205 7 during during IN cord-322899-uxvlagt3 205 8 infection infection NN cord-322899-uxvlagt3 205 9 Pathogenesis Pathogenesis NNP cord-322899-uxvlagt3 205 10 of of IN cord-322899-uxvlagt3 205 11 porcine porcine JJ cord-322899-uxvlagt3 205 12 reproductive reproductive JJ cord-322899-uxvlagt3 205 13 and and CC cord-322899-uxvlagt3 205 14 respiratory respiratory JJ cord-322899-uxvlagt3 205 15 syndrome syndrome NN cord-322899-uxvlagt3 205 16 virus virus NN cord-322899-uxvlagt3 205 17 - - HYPH cord-322899-uxvlagt3 205 18 induced induce VBN cord-322899-uxvlagt3 205 19 increase increase NN cord-322899-uxvlagt3 205 20 in in IN cord-322899-uxvlagt3 205 21 susceptibility susceptibility NN cord-322899-uxvlagt3 205 22 to to IN cord-322899-uxvlagt3 205 23 Streptococcus streptococcus NN cord-322899-uxvlagt3 205 24 suis suis NN cord-322899-uxvlagt3 205 25 infection infection NN cord-322899-uxvlagt3 206 1 Middle Middle NNP cord-322899-uxvlagt3 206 2 East East NNP cord-322899-uxvlagt3 206 3 respiratory respiratory JJ cord-322899-uxvlagt3 206 4 syndrome syndrome NN cord-322899-uxvlagt3 206 5 coronavirus coronavirus NN cord-322899-uxvlagt3 206 6 : : : cord-322899-uxvlagt3 207 1 another another DT cord-322899-uxvlagt3 207 2 zoonotic zoonotic JJ cord-322899-uxvlagt3 207 3 betacoronavirus betacoronavirus NN cord-322899-uxvlagt3 207 4 causing cause VBG cord-322899-uxvlagt3 207 5 SARS SARS NNP cord-322899-uxvlagt3 207 6 - - HYPH cord-322899-uxvlagt3 207 7 like like JJ cord-322899-uxvlagt3 207 8 disease disease NN cord-322899-uxvlagt3 208 1 Retinoic retinoic JJ cord-322899-uxvlagt3 208 2 acid acid NN cord-322899-uxvlagt3 208 3 inhibits inhibit VBZ cord-322899-uxvlagt3 208 4 Th17 Th17 . cord-322899-uxvlagt3 209 1 polarization polarization NN cord-322899-uxvlagt3 209 2 and and CC cord-322899-uxvlagt3 209 3 enhances enhance VBZ cord-322899-uxvlagt3 209 4 FoxP3 FoxP3 NNP cord-322899-uxvlagt3 209 5 expression expression NN cord-322899-uxvlagt3 209 6 through through IN cord-322899-uxvlagt3 209 7 a a DT cord-322899-uxvlagt3 209 8 Stat-3 Stat-3 NNP cord-322899-uxvlagt3 209 9 / / SYM cord-322899-uxvlagt3 209 10 Stat-5 Stat-5 NNP cord-322899-uxvlagt3 209 11 independent independent JJ cord-322899-uxvlagt3 209 12 signaling signal VBG cord-322899-uxvlagt3 209 13 pathway pathway NN cord-322899-uxvlagt3 209 14 Role role NN cord-322899-uxvlagt3 209 15 of of IN cord-322899-uxvlagt3 209 16 Vitamin vitamin NN cord-322899-uxvlagt3 209 17 A a NN cord-322899-uxvlagt3 209 18 in in IN cord-322899-uxvlagt3 209 19 the the DT cord-322899-uxvlagt3 209 20 Immune Immune NNP cord-322899-uxvlagt3 209 21 System System NNP cord-322899-uxvlagt3 209 22 Role role NN cord-322899-uxvlagt3 209 23 of of IN cord-322899-uxvlagt3 209 24 Fat fat JJ cord-322899-uxvlagt3 209 25 - - HYPH cord-322899-uxvlagt3 209 26 Soluble soluble JJ cord-322899-uxvlagt3 209 27 Vitamins vitamin NNS cord-322899-uxvlagt3 209 28 A A NNP cord-322899-uxvlagt3 209 29 and and CC cord-322899-uxvlagt3 209 30 D d NN cord-322899-uxvlagt3 209 31 in in IN cord-322899-uxvlagt3 209 32 the the DT cord-322899-uxvlagt3 209 33 Pathogenesis Pathogenesis NNP cord-322899-uxvlagt3 209 34 of of IN cord-322899-uxvlagt3 209 35 Influenza Influenza NNP cord-322899-uxvlagt3 209 36 : : : cord-322899-uxvlagt3 209 37 A a DT cord-322899-uxvlagt3 209 38 New New NNP cord-322899-uxvlagt3 209 39 Perspective perspective NN cord-322899-uxvlagt3 209 40 . . . cord-322899-uxvlagt3 210 1 ISRN ISRN NNP cord-322899-uxvlagt3 210 2 Infectious Infectious NNP cord-322899-uxvlagt3 210 3 Diseases Diseases NNPS cord-322899-uxvlagt3 210 4 ID ID NNP cord-322899-uxvlagt3 210 5 246737 246737 CD cord-322899-uxvlagt3 210 6 Effects effect NNS cord-322899-uxvlagt3 210 7 of of IN cord-322899-uxvlagt3 210 8 vitamin vitamin NN cord-322899-uxvlagt3 210 9 a a DT cord-322899-uxvlagt3 210 10 supplementation supplementation NN cord-322899-uxvlagt3 210 11 on on IN cord-322899-uxvlagt3 210 12 immune immune JJ cord-322899-uxvlagt3 210 13 responses response NNS cord-322899-uxvlagt3 210 14 and and CC cord-322899-uxvlagt3 210 15 correlation correlation NN cord-322899-uxvlagt3 210 16 with with IN cord-322899-uxvlagt3 210 17 clinical clinical JJ cord-322899-uxvlagt3 210 18 outcomes outcome NNS cord-322899-uxvlagt3 211 1 Vitamin vitamin NN cord-322899-uxvlagt3 211 2 - - HYPH cord-322899-uxvlagt3 211 3 mediated mediate VBN cord-322899-uxvlagt3 211 4 regulation regulation NN cord-322899-uxvlagt3 211 5 of of IN cord-322899-uxvlagt3 211 6 intestinal intestinal JJ cord-322899-uxvlagt3 211 7 immunity immunity NN cord-322899-uxvlagt3 211 8 High high JJ cord-322899-uxvlagt3 211 9 - - HYPH cord-322899-uxvlagt3 211 10 dose dose NN cord-322899-uxvlagt3 211 11 dietary dietary JJ cord-322899-uxvlagt3 211 12 zinc zinc NN cord-322899-uxvlagt3 211 13 oxide oxide NN cord-322899-uxvlagt3 211 14 mitigates mitigate VBZ cord-322899-uxvlagt3 211 15 infection infection NN cord-322899-uxvlagt3 211 16 with with IN cord-322899-uxvlagt3 211 17 transmissible transmissible JJ cord-322899-uxvlagt3 211 18 gastroenteritis gastroenteritis NN cord-322899-uxvlagt3 211 19 virus virus NN cord-322899-uxvlagt3 211 20 in in IN cord-322899-uxvlagt3 211 21 piglets piglet NNS cord-322899-uxvlagt3 211 22 Effects effect NNS cord-322899-uxvlagt3 211 23 of of IN cord-322899-uxvlagt3 211 24 dietary dietary JJ cord-322899-uxvlagt3 211 25 vitamin vitamin NN cord-322899-uxvlagt3 211 26 A a DT cord-322899-uxvlagt3 211 27 content content NN cord-322899-uxvlagt3 211 28 on on IN cord-322899-uxvlagt3 211 29 antibody antibody NN cord-322899-uxvlagt3 211 30 responses response NNS cord-322899-uxvlagt3 211 31 of of IN cord-322899-uxvlagt3 211 32 feedlot feedlot NN cord-322899-uxvlagt3 211 33 calves calf NNS cord-322899-uxvlagt3 211 34 inoculated inoculate VBN cord-322899-uxvlagt3 211 35 intramuscularly intramuscularly RB cord-322899-uxvlagt3 211 36 with with IN cord-322899-uxvlagt3 211 37 an an DT cord-322899-uxvlagt3 211 38 inactivated inactivate VBN cord-322899-uxvlagt3 211 39 bovine bovine JJ cord-322899-uxvlagt3 211 40 coronavirus coronavirus NN cord-322899-uxvlagt3 211 41 vaccine vaccine NN cord-322899-uxvlagt3 211 42 Epithelia Epithelia NNP cord-322899-uxvlagt3 211 43 - - HYPH cord-322899-uxvlagt3 211 44 damaging damage VBG cord-322899-uxvlagt3 211 45 virus virus NN cord-322899-uxvlagt3 211 46 infections infection NNS cord-322899-uxvlagt3 211 47 affect affect VBP cord-322899-uxvlagt3 211 48 vitamin vitamin NN cord-322899-uxvlagt3 211 49 A a DT cord-322899-uxvlagt3 211 50 status status NN cord-322899-uxvlagt3 211 51 in in IN cord-322899-uxvlagt3 211 52 chickens chicken NNS cord-322899-uxvlagt3 211 53 Metabolism metabolism NN cord-322899-uxvlagt3 211 54 of of IN cord-322899-uxvlagt3 211 55 Dietary dietary JJ cord-322899-uxvlagt3 211 56 and and CC cord-322899-uxvlagt3 211 57 Microbial microbial JJ cord-322899-uxvlagt3 211 58 Vitamin vitamin NN cord-322899-uxvlagt3 211 59 B B NNP cord-322899-uxvlagt3 211 60 Family Family NNP cord-322899-uxvlagt3 211 61 in in IN cord-322899-uxvlagt3 211 62 the the DT cord-322899-uxvlagt3 211 63 Regulation Regulation NNP cord-322899-uxvlagt3 211 64 of of IN cord-322899-uxvlagt3 211 65 Host Host NNP cord-322899-uxvlagt3 211 66 Immunity Immunity NNP cord-322899-uxvlagt3 212 1 The the DT cord-322899-uxvlagt3 212 2 effects effect NNS cord-322899-uxvlagt3 212 3 of of IN cord-322899-uxvlagt3 212 4 vitamin vitamin NN cord-322899-uxvlagt3 212 5 B b NN cord-322899-uxvlagt3 212 6 on on IN cord-322899-uxvlagt3 212 7 the the DT cord-322899-uxvlagt3 212 8 immune immune JJ cord-322899-uxvlagt3 212 9 / / SYM cord-322899-uxvlagt3 212 10 cytokine cytokine NN cord-322899-uxvlagt3 212 11 network network NN cord-322899-uxvlagt3 212 12 and and CC cord-322899-uxvlagt3 212 13 their -PRON- PRP$ cord-322899-uxvlagt3 212 14 involvement involvement NN cord-322899-uxvlagt3 212 15 in in IN cord-322899-uxvlagt3 212 16 depression depression NN cord-322899-uxvlagt3 212 17 Vitamin vitamin NN cord-322899-uxvlagt3 212 18 B5 B5 NNP cord-322899-uxvlagt3 212 19 reduces reduce VBZ cord-322899-uxvlagt3 212 20 bacterial bacterial JJ cord-322899-uxvlagt3 212 21 growth growth NN cord-322899-uxvlagt3 212 22 via via IN cord-322899-uxvlagt3 212 23 regulating regulate VBG cord-322899-uxvlagt3 212 24 innate innate JJ cord-322899-uxvlagt3 212 25 immunity immunity NN cord-322899-uxvlagt3 212 26 and and CC cord-322899-uxvlagt3 212 27 adaptive adaptive JJ cord-322899-uxvlagt3 212 28 immunity immunity NN cord-322899-uxvlagt3 212 29 in in IN cord-322899-uxvlagt3 212 30 mice mouse NNS cord-322899-uxvlagt3 212 31 infected infect VBN cord-322899-uxvlagt3 212 32 with with IN cord-322899-uxvlagt3 212 33 Mycobacterium Mycobacterium NNP cord-322899-uxvlagt3 212 34 tuberculosis tuberculosis NN cord-322899-uxvlagt3 212 35 Effects effect NNS cord-322899-uxvlagt3 212 36 of of IN cord-322899-uxvlagt3 212 37 vitamin vitamin NN cord-322899-uxvlagt3 212 38 B6 b6 NN cord-322899-uxvlagt3 212 39 deficiency deficiency NN cord-322899-uxvlagt3 212 40 on on IN cord-322899-uxvlagt3 212 41 the the DT cord-322899-uxvlagt3 212 42 composition composition NN cord-322899-uxvlagt3 212 43 and and CC cord-322899-uxvlagt3 212 44 functional functional JJ cord-322899-uxvlagt3 212 45 potential potential NN cord-322899-uxvlagt3 212 46 of of IN cord-322899-uxvlagt3 212 47 T T NNP cord-322899-uxvlagt3 212 48 cell cell NN cord-322899-uxvlagt3 212 49 populations population NNS cord-322899-uxvlagt3 212 50 Inflammation inflammation NN cord-322899-uxvlagt3 212 51 , , , cord-322899-uxvlagt3 212 52 vitamin vitamin NN cord-322899-uxvlagt3 212 53 B6 b6 NN cord-322899-uxvlagt3 212 54 and and CC cord-322899-uxvlagt3 212 55 related relate VBN cord-322899-uxvlagt3 212 56 pathways pathway NNS cord-322899-uxvlagt3 213 1 The the DT cord-322899-uxvlagt3 213 2 role role NN cord-322899-uxvlagt3 213 3 of of IN cord-322899-uxvlagt3 213 4 thiamine thiamine NN cord-322899-uxvlagt3 213 5 in in IN cord-322899-uxvlagt3 213 6 HIV HIV NNP cord-322899-uxvlagt3 213 7 infection infection NN cord-322899-uxvlagt3 213 8 Inactivation Inactivation NNP cord-322899-uxvlagt3 213 9 of of IN cord-322899-uxvlagt3 213 10 Middle Middle NNP cord-322899-uxvlagt3 213 11 East East NNP cord-322899-uxvlagt3 213 12 respiratory respiratory JJ cord-322899-uxvlagt3 213 13 syndrome syndrome NN cord-322899-uxvlagt3 213 14 coronavirus coronavirus NN cord-322899-uxvlagt3 213 15 ( ( -LRB- cord-322899-uxvlagt3 213 16 MERS MERS NNP cord-322899-uxvlagt3 213 17 - - HYPH cord-322899-uxvlagt3 213 18 CoV CoV NNP cord-322899-uxvlagt3 213 19 ) ) -RRB- cord-322899-uxvlagt3 213 20 in in IN cord-322899-uxvlagt3 213 21 plasma plasma NN cord-322899-uxvlagt3 213 22 products product NNS cord-322899-uxvlagt3 213 23 using use VBG cord-322899-uxvlagt3 213 24 a a DT cord-322899-uxvlagt3 213 25 riboflavin riboflavin NN cord-322899-uxvlagt3 213 26 - - HYPH cord-322899-uxvlagt3 213 27 based base VBN cord-322899-uxvlagt3 213 28 and and CC cord-322899-uxvlagt3 213 29 ultraviolet ultraviolet JJ cord-322899-uxvlagt3 213 30 light light NN cord-322899-uxvlagt3 213 31 - - HYPH cord-322899-uxvlagt3 213 32 based base VBN cord-322899-uxvlagt3 213 33 photochemical photochemical JJ cord-322899-uxvlagt3 213 34 treatment treatment NN cord-322899-uxvlagt3 213 35 Micronutrient Micronutrient NNP cord-322899-uxvlagt3 213 36 deficiencies deficiency NNS cord-322899-uxvlagt3 213 37 are be VBP cord-322899-uxvlagt3 213 38 associated associate VBN cord-322899-uxvlagt3 213 39 with with IN cord-322899-uxvlagt3 213 40 impaired impaired JJ cord-322899-uxvlagt3 213 41 immune immune JJ cord-322899-uxvlagt3 213 42 response response NN cord-322899-uxvlagt3 213 43 and and CC cord-322899-uxvlagt3 213 44 higher high JJR cord-322899-uxvlagt3 213 45 burden burden NN cord-322899-uxvlagt3 213 46 of of IN cord-322899-uxvlagt3 213 47 respiratory respiratory JJ cord-322899-uxvlagt3 213 48 infections infection NNS cord-322899-uxvlagt3 213 49 in in IN cord-322899-uxvlagt3 213 50 elderly elderly JJ cord-322899-uxvlagt3 213 51 Ecuadorians Ecuadorians NNPS cord-322899-uxvlagt3 214 1 A a DT cord-322899-uxvlagt3 214 2 system system NN cord-322899-uxvlagt3 214 3 of of IN cord-322899-uxvlagt3 214 4 protein protein NN cord-322899-uxvlagt3 214 5 target target NN cord-322899-uxvlagt3 214 6 sequences sequence NNS cord-322899-uxvlagt3 214 7 for for IN cord-322899-uxvlagt3 214 8 anti anti JJ cord-322899-uxvlagt3 214 9 - - JJ cord-322899-uxvlagt3 214 10 RNA rna JJ cord-322899-uxvlagt3 214 11 - - HYPH cord-322899-uxvlagt3 214 12 viral viral JJ cord-322899-uxvlagt3 214 13 chemotherapy chemotherapy NN cord-322899-uxvlagt3 214 14 by by IN cord-322899-uxvlagt3 214 15 a a DT cord-322899-uxvlagt3 214 16 vitamin vitamin NN cord-322899-uxvlagt3 214 17 B6-derived b6-derive VBD cord-322899-uxvlagt3 214 18 zinc zinc NN cord-322899-uxvlagt3 214 19 - - HYPH cord-322899-uxvlagt3 214 20 chelating chelate VBG cord-322899-uxvlagt3 214 21 trioxa trioxa NNP cord-322899-uxvlagt3 214 22 - - HYPH cord-322899-uxvlagt3 214 23 adamantane adamantane NNP cord-322899-uxvlagt3 214 24 - - HYPH cord-322899-uxvlagt3 214 25 triol triol NNP cord-322899-uxvlagt3 214 26 Vitamin vitamin NN cord-322899-uxvlagt3 214 27 C c NN cord-322899-uxvlagt3 214 28 and and CC cord-322899-uxvlagt3 214 29 immune immune JJ cord-322899-uxvlagt3 214 30 cell cell NN cord-322899-uxvlagt3 214 31 function function NN cord-322899-uxvlagt3 214 32 in in IN cord-322899-uxvlagt3 214 33 inflammation inflammation NN cord-322899-uxvlagt3 214 34 and and CC cord-322899-uxvlagt3 214 35 cancer cancer NN cord-322899-uxvlagt3 214 36 Vitamin vitamin NN cord-322899-uxvlagt3 214 37 C c NN cord-322899-uxvlagt3 214 38 : : : cord-322899-uxvlagt3 214 39 an an DT cord-322899-uxvlagt3 214 40 essential essential JJ cord-322899-uxvlagt3 214 41 " " `` cord-322899-uxvlagt3 214 42 stress stress NN cord-322899-uxvlagt3 214 43 hormone hormone NN cord-322899-uxvlagt3 214 44 " " '' cord-322899-uxvlagt3 214 45 during during IN cord-322899-uxvlagt3 214 46 sepsis sepsis NN cord-322899-uxvlagt3 214 47 Vitamin vitamin NN cord-322899-uxvlagt3 214 48 C C NNP cord-322899-uxvlagt3 214 49 and and CC cord-322899-uxvlagt3 214 50 Immune Immune NNP cord-322899-uxvlagt3 214 51 Function Function NNP cord-322899-uxvlagt3 214 52 Vitamin vitamin NN cord-322899-uxvlagt3 214 53 C c NN cord-322899-uxvlagt3 214 54 Is be VBZ cord-322899-uxvlagt3 214 55 an an DT cord-322899-uxvlagt3 214 56 Essential Essential NNP cord-322899-uxvlagt3 214 57 Factor factor NN cord-322899-uxvlagt3 214 58 on on IN cord-322899-uxvlagt3 214 59 the the DT cord-322899-uxvlagt3 214 60 Anti anti JJ cord-322899-uxvlagt3 214 61 - - JJ cord-322899-uxvlagt3 214 62 viral viral JJ cord-322899-uxvlagt3 214 63 Immune Immune NNP cord-322899-uxvlagt3 214 64 Responses response NNS cord-322899-uxvlagt3 214 65 through through IN cord-322899-uxvlagt3 214 66 the the DT cord-322899-uxvlagt3 214 67 Production production NN cord-322899-uxvlagt3 214 68 of of IN cord-322899-uxvlagt3 214 69 Interferon Interferon NNP cord-322899-uxvlagt3 214 70 - - HYPH cord-322899-uxvlagt3 214 71 α α NNP cord-322899-uxvlagt3 214 72 / / SYM cord-322899-uxvlagt3 214 73 β β NN cord-322899-uxvlagt3 214 74 at at IN cord-322899-uxvlagt3 214 75 the the DT cord-322899-uxvlagt3 214 76 Initial Initial NNP cord-322899-uxvlagt3 214 77 Stage Stage NNP cord-322899-uxvlagt3 214 78 of of IN cord-322899-uxvlagt3 214 79 Influenza Influenza NNP cord-322899-uxvlagt3 214 80 A A NNP cord-322899-uxvlagt3 214 81 Virus virus NN cord-322899-uxvlagt3 214 82 ( ( -LRB- cord-322899-uxvlagt3 214 83 H3N2 H3N2 NNP cord-322899-uxvlagt3 214 84 ) ) -RRB- cord-322899-uxvlagt3 214 85 Infection infection NN cord-322899-uxvlagt3 214 86 Ascorbic ascorbic NN cord-322899-uxvlagt3 214 87 acid acid NN cord-322899-uxvlagt3 214 88 and and CC cord-322899-uxvlagt3 214 89 infectious infectious JJ cord-322899-uxvlagt3 214 90 bronchitis bronchitis NN cord-322899-uxvlagt3 214 91 infections infection NNS cord-322899-uxvlagt3 214 92 in in IN cord-322899-uxvlagt3 214 93 broilers broiler NNS cord-322899-uxvlagt3 215 1 The the DT cord-322899-uxvlagt3 215 2 effect effect NN cord-322899-uxvlagt3 215 3 of of IN cord-322899-uxvlagt3 215 4 ascorbic ascorbic NN cord-322899-uxvlagt3 215 5 acid acid NN cord-322899-uxvlagt3 215 6 on on IN cord-322899-uxvlagt3 215 7 infection infection NN cord-322899-uxvlagt3 215 8 chick chick NN cord-322899-uxvlagt3 215 9 - - HYPH cord-322899-uxvlagt3 215 10 embryo embryo NN cord-322899-uxvlagt3 215 11 ciliated ciliated JJ cord-322899-uxvlagt3 215 12 tracheal tracheal JJ cord-322899-uxvlagt3 215 13 organ organ NN cord-322899-uxvlagt3 215 14 cultures culture NNS cord-322899-uxvlagt3 215 15 by by IN cord-322899-uxvlagt3 215 16 coronavirus coronavirus NN cord-322899-uxvlagt3 216 1 The the DT cord-322899-uxvlagt3 216 2 Protection Protection NNP cord-322899-uxvlagt3 216 3 Potential Potential NNP cord-322899-uxvlagt3 216 4 of of IN cord-322899-uxvlagt3 216 5 Antioxidant antioxidant JJ cord-322899-uxvlagt3 216 6 Vitamins vitamin NNS cord-322899-uxvlagt3 216 7 Against against IN cord-322899-uxvlagt3 216 8 Acute acute JJ cord-322899-uxvlagt3 216 9 Respiratory respiratory JJ cord-322899-uxvlagt3 216 10 Distress Distress NNP cord-322899-uxvlagt3 216 11 Syndrome Syndrome NNP cord-322899-uxvlagt3 216 12 : : : cord-322899-uxvlagt3 216 13 a a DT cord-322899-uxvlagt3 216 14 Rat Rat NNP cord-322899-uxvlagt3 216 15 Trial Trial NNP cord-322899-uxvlagt3 216 16 Effect Effect NNP cord-322899-uxvlagt3 216 17 of of IN cord-322899-uxvlagt3 216 18 Vitamin vitamin NN cord-322899-uxvlagt3 216 19 C c NN cord-322899-uxvlagt3 216 20 Infusion Infusion NNP cord-322899-uxvlagt3 216 21 on on IN cord-322899-uxvlagt3 216 22 Organ Organ NNP cord-322899-uxvlagt3 216 23 Failure Failure NNP cord-322899-uxvlagt3 216 24 and and CC cord-322899-uxvlagt3 216 25 Biomarkers Biomarkers NNPS cord-322899-uxvlagt3 216 26 of of IN cord-322899-uxvlagt3 216 27 Inflammation Inflammation NNP cord-322899-uxvlagt3 216 28 and and CC cord-322899-uxvlagt3 216 29 Vascular Vascular NNP cord-322899-uxvlagt3 216 30 Injury Injury NNP cord-322899-uxvlagt3 216 31 in in IN cord-322899-uxvlagt3 216 32 Patients patient NNS cord-322899-uxvlagt3 216 33 With with IN cord-322899-uxvlagt3 216 34 Sepsis sepsis NN cord-322899-uxvlagt3 216 35 and and CC cord-322899-uxvlagt3 216 36 Severe severe JJ cord-322899-uxvlagt3 216 37 Acute acute JJ cord-322899-uxvlagt3 216 38 Respiratory respiratory JJ cord-322899-uxvlagt3 216 39 Failure failure NN cord-322899-uxvlagt3 216 40 : : : cord-322899-uxvlagt3 217 1 The the DT cord-322899-uxvlagt3 217 2 CITRIS CITRIS NNP cord-322899-uxvlagt3 217 3 - - HYPH cord-322899-uxvlagt3 217 4 ALI ALI NNP cord-322899-uxvlagt3 217 5 Randomized Randomized NNP cord-322899-uxvlagt3 217 6 Clinical Clinical NNP cord-322899-uxvlagt3 217 7 Trial Trial NNP cord-322899-uxvlagt3 217 8 The the DT cord-322899-uxvlagt3 217 9 antiviral antiviral JJ cord-322899-uxvlagt3 217 10 properties property NNS cord-322899-uxvlagt3 217 11 of of IN cord-322899-uxvlagt3 217 12 vitamin vitamin NN cord-322899-uxvlagt3 217 13 C c NN cord-322899-uxvlagt3 217 14 Vitamin vitamin NN cord-322899-uxvlagt3 217 15 C C NNP cord-322899-uxvlagt3 217 16 and and CC cord-322899-uxvlagt3 217 17 SARS SARS NNP cord-322899-uxvlagt3 217 18 coronavirus coronavirus NN cord-322899-uxvlagt3 217 19 Ascorbic ascorbic NN cord-322899-uxvlagt3 217 20 acid acid NN cord-322899-uxvlagt3 217 21 role role NN cord-322899-uxvlagt3 217 22 in in IN cord-322899-uxvlagt3 217 23 containment containment NN cord-322899-uxvlagt3 217 24 of of IN cord-322899-uxvlagt3 217 25 the the DT cord-322899-uxvlagt3 217 26 world world NN cord-322899-uxvlagt3 217 27 avian avian JJ cord-322899-uxvlagt3 217 28 flu flu NN cord-322899-uxvlagt3 217 29 pandemic pandemic NN cord-322899-uxvlagt3 217 30 Vitamin vitamin NN cord-322899-uxvlagt3 217 31 D d NN cord-322899-uxvlagt3 217 32 : : : cord-322899-uxvlagt3 218 1 Effect effect NN cord-322899-uxvlagt3 218 2 on on IN cord-322899-uxvlagt3 218 3 Haematopoiesis Haematopoiesis NNP cord-322899-uxvlagt3 218 4 and and CC cord-322899-uxvlagt3 218 5 Immune Immune NNP cord-322899-uxvlagt3 218 6 System System NNP cord-322899-uxvlagt3 218 7 and and CC cord-322899-uxvlagt3 218 8 Clinical Clinical NNP cord-322899-uxvlagt3 218 9 Applications Applications NNPS cord-322899-uxvlagt3 218 10 Vitamin vitamin NN cord-322899-uxvlagt3 218 11 D3 D3 NNP cord-322899-uxvlagt3 218 12 down down RB cord-322899-uxvlagt3 218 13 - - HYPH cord-322899-uxvlagt3 218 14 regulates regulate VBZ cord-322899-uxvlagt3 218 15 monocyte monocyte NNP cord-322899-uxvlagt3 218 16 TLR TLR NNP cord-322899-uxvlagt3 218 17 expression expression NN cord-322899-uxvlagt3 218 18 and and CC cord-322899-uxvlagt3 218 19 triggers trigger VBZ cord-322899-uxvlagt3 218 20 hyporesponsiveness hyporesponsiveness NN cord-322899-uxvlagt3 218 21 to to IN cord-322899-uxvlagt3 218 22 pathogen pathogen NN cord-322899-uxvlagt3 218 23 - - HYPH cord-322899-uxvlagt3 218 24 associated associate VBN cord-322899-uxvlagt3 218 25 molecular molecular JJ cord-322899-uxvlagt3 218 26 patterns pattern NNS cord-322899-uxvlagt3 218 27 25-Dihydroxyvitamin 25-dihydroxyvitamin CD cord-322899-uxvlagt3 218 28 D3 D3 NNP cord-322899-uxvlagt3 218 29 has have VBZ cord-322899-uxvlagt3 218 30 a a DT cord-322899-uxvlagt3 218 31 direct direct JJ cord-322899-uxvlagt3 218 32 effect effect NN cord-322899-uxvlagt3 218 33 on on IN cord-322899-uxvlagt3 218 34 naive naive JJ cord-322899-uxvlagt3 218 35 CD4(+ CD4(+ NNS cord-322899-uxvlagt3 218 36 ) ) -RRB- cord-322899-uxvlagt3 219 1 T T NNP cord-322899-uxvlagt3 219 2 cells cell NNS cord-322899-uxvlagt3 219 3 to to TO cord-322899-uxvlagt3 219 4 enhance enhance VB cord-322899-uxvlagt3 219 5 the the DT cord-322899-uxvlagt3 219 6 development development NN cord-322899-uxvlagt3 219 7 of of IN cord-322899-uxvlagt3 219 8 Th2 th2 CD cord-322899-uxvlagt3 219 9 cells cell NNS cord-322899-uxvlagt3 219 10 Acute acute JJ cord-322899-uxvlagt3 219 11 phase phase NN cord-322899-uxvlagt3 219 12 response response NN cord-322899-uxvlagt3 219 13 elicited elicit VBN cord-322899-uxvlagt3 219 14 by by IN cord-322899-uxvlagt3 219 15 experimental experimental JJ cord-322899-uxvlagt3 219 16 bovine bovine JJ cord-322899-uxvlagt3 219 17 diarrhea diarrhea NN cord-322899-uxvlagt3 219 18 virus virus NN cord-322899-uxvlagt3 219 19 ( ( -LRB- cord-322899-uxvlagt3 219 20 BVDV BVDV NNP cord-322899-uxvlagt3 219 21 ) ) -RRB- cord-322899-uxvlagt3 219 22 infection infection NN cord-322899-uxvlagt3 219 23 is be VBZ cord-322899-uxvlagt3 219 24 associated associate VBN cord-322899-uxvlagt3 219 25 with with IN cord-322899-uxvlagt3 219 26 decreased decreased JJ cord-322899-uxvlagt3 219 27 vitamin vitamin NN cord-322899-uxvlagt3 219 28 D d NN cord-322899-uxvlagt3 219 29 and and CC cord-322899-uxvlagt3 219 30 E e NN cord-322899-uxvlagt3 219 31 status status NN cord-322899-uxvlagt3 219 32 of of IN cord-322899-uxvlagt3 220 1 vitamin vitamin NN cord-322899-uxvlagt3 220 2 - - HYPH cord-322899-uxvlagt3 220 3 replete replete VBG cord-322899-uxvlagt3 220 4 preruminant preruminant JJ cord-322899-uxvlagt3 220 5 calves calf NNS cord-322899-uxvlagt3 220 6 Vitamin vitamin NN cord-322899-uxvlagt3 220 7 D d NN cord-322899-uxvlagt3 220 8 increases increase VBZ cord-322899-uxvlagt3 220 9 the the DT cord-322899-uxvlagt3 220 10 antiviral antiviral JJ cord-322899-uxvlagt3 220 11 activity activity NN cord-322899-uxvlagt3 220 12 of of IN cord-322899-uxvlagt3 220 13 bronchial bronchial JJ cord-322899-uxvlagt3 220 14 epithelial epithelial JJ cord-322899-uxvlagt3 220 15 cells cell NNS cord-322899-uxvlagt3 220 16 in in IN cord-322899-uxvlagt3 220 17 vitro vitro FW cord-322899-uxvlagt3 220 18 Release release NN cord-322899-uxvlagt3 220 19 of of IN cord-322899-uxvlagt3 220 20 severe severe JJ cord-322899-uxvlagt3 220 21 acute acute JJ cord-322899-uxvlagt3 220 22 respiratory respiratory JJ cord-322899-uxvlagt3 220 23 syndrome syndrome NN cord-322899-uxvlagt3 220 24 coronavirus coronavirus NN cord-322899-uxvlagt3 220 25 nuclear nuclear JJ cord-322899-uxvlagt3 220 26 import import NN cord-322899-uxvlagt3 220 27 block block NN cord-322899-uxvlagt3 220 28 enhances enhance VBZ cord-322899-uxvlagt3 220 29 host host NN cord-322899-uxvlagt3 220 30 transcription transcription NN cord-322899-uxvlagt3 220 31 in in IN cord-322899-uxvlagt3 220 32 human human JJ cord-322899-uxvlagt3 220 33 lung lung NN cord-322899-uxvlagt3 220 34 cells cell NNS cord-322899-uxvlagt3 220 35 Vitamin vitamin NN cord-322899-uxvlagt3 220 36 D d NN cord-322899-uxvlagt3 220 37 and and CC cord-322899-uxvlagt3 220 38 mortality mortality NN cord-322899-uxvlagt3 220 39 : : : cord-322899-uxvlagt3 220 40 meta meta NN cord-322899-uxvlagt3 220 41 - - HYPH cord-322899-uxvlagt3 220 42 analysis analysis NN cord-322899-uxvlagt3 220 43 of of IN cord-322899-uxvlagt3 220 44 individual individual JJ cord-322899-uxvlagt3 220 45 participant participant NN cord-322899-uxvlagt3 220 46 data datum NNS cord-322899-uxvlagt3 220 47 from from IN cord-322899-uxvlagt3 220 48 a a DT cord-322899-uxvlagt3 220 49 large large JJ cord-322899-uxvlagt3 220 50 consortium consortium NN cord-322899-uxvlagt3 220 51 of of IN cord-322899-uxvlagt3 220 52 cohort cohort NN cord-322899-uxvlagt3 220 53 studies study NNS cord-322899-uxvlagt3 220 54 from from IN cord-322899-uxvlagt3 220 55 Europe Europe NNP cord-322899-uxvlagt3 220 56 and and CC cord-322899-uxvlagt3 220 57 the the DT cord-322899-uxvlagt3 220 58 United United NNP cord-322899-uxvlagt3 220 59 States States NNP cord-322899-uxvlagt3 220 60 Evaluation Evaluation NNP cord-322899-uxvlagt3 220 61 of of IN cord-322899-uxvlagt3 220 62 vitamin vitamin NN cord-322899-uxvlagt3 220 63 D d NN cord-322899-uxvlagt3 220 64 endocrine endocrine NN cord-322899-uxvlagt3 220 65 system system NN cord-322899-uxvlagt3 220 66 ( ( -LRB- cord-322899-uxvlagt3 220 67 VDES VDES NNP cord-322899-uxvlagt3 220 68 ) ) -RRB- cord-322899-uxvlagt3 220 69 status status NN cord-322899-uxvlagt3 220 70 and and CC cord-322899-uxvlagt3 220 71 response response NN cord-322899-uxvlagt3 220 72 to to IN cord-322899-uxvlagt3 220 73 treatment treatment NN cord-322899-uxvlagt3 220 74 of of IN cord-322899-uxvlagt3 220 75 patients patient NNS cord-322899-uxvlagt3 220 76 in in IN cord-322899-uxvlagt3 220 77 intensive intensive JJ cord-322899-uxvlagt3 220 78 care care NN cord-322899-uxvlagt3 220 79 units unit NNS cord-322899-uxvlagt3 220 80 ( ( -LRB- cord-322899-uxvlagt3 220 81 ICUs ICUs NNP cord-322899-uxvlagt3 220 82 ) ) -RRB- cord-322899-uxvlagt3 220 83 using use VBG cord-322899-uxvlagt3 220 84 an an DT cord-322899-uxvlagt3 220 85 online online JJ cord-322899-uxvlagt3 220 86 SPE SPE NNP cord-322899-uxvlagt3 220 87 - - HYPH cord-322899-uxvlagt3 220 88 LC LC NNP cord-322899-uxvlagt3 220 89 - - HYPH cord-322899-uxvlagt3 220 90 MS MS NNP cord-322899-uxvlagt3 220 91 / / SYM cord-322899-uxvlagt3 220 92 MS MS NNP cord-322899-uxvlagt3 220 93 method method NN cord-322899-uxvlagt3 220 94 Oxidative oxidative JJ cord-322899-uxvlagt3 220 95 stress stress NN cord-322899-uxvlagt3 220 96 in in IN cord-322899-uxvlagt3 220 97 critically critically RB cord-322899-uxvlagt3 220 98 ill ill RB cord-322899-uxvlagt3 220 99 ventilated ventilate VBN cord-322899-uxvlagt3 220 100 adults adult NNS cord-322899-uxvlagt3 220 101 : : : cord-322899-uxvlagt3 220 102 effects effect NNS cord-322899-uxvlagt3 220 103 of of IN cord-322899-uxvlagt3 220 104 vitamin vitamin NN cord-322899-uxvlagt3 220 105 D3 D3 NNP cord-322899-uxvlagt3 220 106 and and CC cord-322899-uxvlagt3 220 107 associations association NNS cord-322899-uxvlagt3 220 108 with with IN cord-322899-uxvlagt3 220 109 alveolar alveolar JJ cord-322899-uxvlagt3 220 110 macrophage macrophage NN cord-322899-uxvlagt3 220 111 function function NN cord-322899-uxvlagt3 220 112 Low Low NNP cord-322899-uxvlagt3 220 113 Retinol Retinol NNP cord-322899-uxvlagt3 220 114 - - HYPH cord-322899-uxvlagt3 220 115 Binding Binding NNP cord-322899-uxvlagt3 220 116 Protein Protein NNP cord-322899-uxvlagt3 220 117 and and CC cord-322899-uxvlagt3 220 118 Vitamin vitamin NN cord-322899-uxvlagt3 220 119 D d NN cord-322899-uxvlagt3 220 120 Levels level NNS cord-322899-uxvlagt3 221 1 Are be VBP cord-322899-uxvlagt3 221 2 Associated associate VBN cord-322899-uxvlagt3 221 3 with with IN cord-322899-uxvlagt3 221 4 Severe severe JJ cord-322899-uxvlagt3 221 5 Outcomes Outcomes NNPS cord-322899-uxvlagt3 221 6 in in IN cord-322899-uxvlagt3 221 7 Children child NNS cord-322899-uxvlagt3 221 8 Hospitalized hospitalize VBN cord-322899-uxvlagt3 221 9 with with IN cord-322899-uxvlagt3 221 10 Lower low JJR cord-322899-uxvlagt3 221 11 Respiratory respiratory JJ cord-322899-uxvlagt3 221 12 Tract tract NN cord-322899-uxvlagt3 221 13 Infection infection NN cord-322899-uxvlagt3 221 14 and and CC cord-322899-uxvlagt3 221 15 Respiratory respiratory JJ cord-322899-uxvlagt3 221 16 Syncytial Syncytial NNP cord-322899-uxvlagt3 221 17 Virus Virus NNP cord-322899-uxvlagt3 221 18 or or CC cord-322899-uxvlagt3 221 19 Human Human NNP cord-322899-uxvlagt3 221 20 Metapneumovirus Metapneumovirus NNP cord-322899-uxvlagt3 221 21 Detection Detection NNP cord-322899-uxvlagt3 221 22 Steroids Steroids NNPS cord-322899-uxvlagt3 221 23 as as IN cord-322899-uxvlagt3 221 24 regulators regulator NNS cord-322899-uxvlagt3 221 25 of of IN cord-322899-uxvlagt3 221 26 the the DT cord-322899-uxvlagt3 221 27 mammalian mammalian JJ cord-322899-uxvlagt3 221 28 immune immune JJ cord-322899-uxvlagt3 221 29 response response NN cord-322899-uxvlagt3 221 30 Vitamin vitamin NN cord-322899-uxvlagt3 221 31 D d NN cord-322899-uxvlagt3 221 32 and and CC cord-322899-uxvlagt3 221 33 immune immune JJ cord-322899-uxvlagt3 221 34 function function NN cord-322899-uxvlagt3 222 1 The the DT cord-322899-uxvlagt3 222 2 possible possible JJ cord-322899-uxvlagt3 222 3 roles role NNS cord-322899-uxvlagt3 222 4 of of IN cord-322899-uxvlagt3 222 5 solar solar JJ cord-322899-uxvlagt3 222 6 ultraviolet ultraviolet NN cord-322899-uxvlagt3 222 7 - - HYPH cord-322899-uxvlagt3 222 8 B b NN cord-322899-uxvlagt3 222 9 radiation radiation NN cord-322899-uxvlagt3 222 10 and and CC cord-322899-uxvlagt3 222 11 vitamin vitamin NN cord-322899-uxvlagt3 222 12 D d NN cord-322899-uxvlagt3 222 13 in in IN cord-322899-uxvlagt3 222 14 reducing reduce VBG cord-322899-uxvlagt3 222 15 case case NN cord-322899-uxvlagt3 222 16 - - HYPH cord-322899-uxvlagt3 222 17 fatality fatality NN cord-322899-uxvlagt3 222 18 rates rate NNS cord-322899-uxvlagt3 222 19 from from IN cord-322899-uxvlagt3 222 20 the the DT cord-322899-uxvlagt3 222 21 1918 1918 CD cord-322899-uxvlagt3 222 22 - - SYM cord-322899-uxvlagt3 222 23 1919 1919 CD cord-322899-uxvlagt3 222 24 influenza influenza NN cord-322899-uxvlagt3 222 25 pandemic pandemic NN cord-322899-uxvlagt3 222 26 in in IN cord-322899-uxvlagt3 222 27 the the DT cord-322899-uxvlagt3 222 28 United United NNP cord-322899-uxvlagt3 222 29 States States NNP cord-322899-uxvlagt3 222 30 Association Association NNP cord-322899-uxvlagt3 222 31 of of IN cord-322899-uxvlagt3 222 32 vitamin vitamin NN cord-322899-uxvlagt3 222 33 D D NNP cord-322899-uxvlagt3 222 34 supplementation supplementation NN cord-322899-uxvlagt3 222 35 with with IN cord-322899-uxvlagt3 222 36 respiratory respiratory JJ cord-322899-uxvlagt3 222 37 tract tract NN cord-322899-uxvlagt3 222 38 infection infection NN cord-322899-uxvlagt3 222 39 in in IN cord-322899-uxvlagt3 222 40 infants infant NNS cord-322899-uxvlagt3 222 41 . . . cord-322899-uxvlagt3 223 1 Matern Matern NNP cord-322899-uxvlagt3 223 2 Child Child NNP cord-322899-uxvlagt3 223 3 Nutr Nutr NNP cord-322899-uxvlagt3 223 4 e12987 e12987 NNP cord-322899-uxvlagt3 224 1 The the DT cord-322899-uxvlagt3 224 2 Role role NN cord-322899-uxvlagt3 224 3 of of IN cord-322899-uxvlagt3 224 4 Vitamin vitamin NN cord-322899-uxvlagt3 224 5 E e NN cord-322899-uxvlagt3 224 6 in in IN cord-322899-uxvlagt3 224 7 Immunity immunity NN cord-322899-uxvlagt3 224 8 Vitamin vitamin NN cord-322899-uxvlagt3 224 9 E e NN cord-322899-uxvlagt3 224 10 supplementation supplementation NN cord-322899-uxvlagt3 224 11 increases increase VBZ cord-322899-uxvlagt3 224 12 T T NNP cord-322899-uxvlagt3 224 13 helper helper NN cord-322899-uxvlagt3 224 14 1 1 CD cord-322899-uxvlagt3 224 15 cytokine cytokine NN cord-322899-uxvlagt3 224 16 production production NN cord-322899-uxvlagt3 224 17 in in IN cord-322899-uxvlagt3 224 18 old old JJ cord-322899-uxvlagt3 224 19 mice mouse NNS cord-322899-uxvlagt3 224 20 infected infect VBN cord-322899-uxvlagt3 224 21 with with IN cord-322899-uxvlagt3 224 22 influenza influenza NN cord-322899-uxvlagt3 224 23 virus virus NN cord-322899-uxvlagt3 224 24 Vitamin vitamin NN cord-322899-uxvlagt3 224 25 E e NN cord-322899-uxvlagt3 224 26 deficiency deficiency NN cord-322899-uxvlagt3 224 27 intensifies intensify VBZ cord-322899-uxvlagt3 224 28 the the DT cord-322899-uxvlagt3 224 29 myocardial myocardial JJ cord-322899-uxvlagt3 224 30 injury injury NN cord-322899-uxvlagt3 224 31 of of IN cord-322899-uxvlagt3 224 32 coxsackievirus coxsackievirus NNP cord-322899-uxvlagt3 224 33 B3 B3 NNP cord-322899-uxvlagt3 224 34 infection infection NN cord-322899-uxvlagt3 224 35 of of IN cord-322899-uxvlagt3 224 36 mice mouse NNS cord-322899-uxvlagt3 224 37 Relationship relationship NN cord-322899-uxvlagt3 224 38 between between IN cord-322899-uxvlagt3 224 39 the the DT cord-322899-uxvlagt3 224 40 level level NN cord-322899-uxvlagt3 224 41 of of IN cord-322899-uxvlagt3 224 42 dietary dietary JJ cord-322899-uxvlagt3 224 43 vitamin vitamin NN cord-322899-uxvlagt3 224 44 E e NN cord-322899-uxvlagt3 224 45 and and CC cord-322899-uxvlagt3 224 46 the the DT cord-322899-uxvlagt3 224 47 immune immune JJ cord-322899-uxvlagt3 224 48 response response NN cord-322899-uxvlagt3 224 49 of of IN cord-322899-uxvlagt3 224 50 broiler broiler NN cord-322899-uxvlagt3 224 51 chickens chicken NNS cord-322899-uxvlagt3 224 52 Metabolic metabolic JJ cord-322899-uxvlagt3 224 53 pathways pathway NNS cord-322899-uxvlagt3 224 54 of of IN cord-322899-uxvlagt3 224 55 lung lung NN cord-322899-uxvlagt3 224 56 inflammation inflammation NN cord-322899-uxvlagt3 224 57 revealed reveal VBN cord-322899-uxvlagt3 224 58 by by IN cord-322899-uxvlagt3 224 59 high high JJ cord-322899-uxvlagt3 224 60 - - HYPH cord-322899-uxvlagt3 224 61 resolution resolution NN cord-322899-uxvlagt3 224 62 metabolomics metabolomic NNS cord-322899-uxvlagt3 224 63 ( ( -LRB- cord-322899-uxvlagt3 224 64 HRM HRM NNP cord-322899-uxvlagt3 224 65 ) ) -RRB- cord-322899-uxvlagt3 224 66 of of IN cord-322899-uxvlagt3 224 67 H1N1 H1N1 NNP cord-322899-uxvlagt3 224 68 influenza influenza NN cord-322899-uxvlagt3 224 69 virus virus NN cord-322899-uxvlagt3 224 70 infection infection NN cord-322899-uxvlagt3 224 71 in in IN cord-322899-uxvlagt3 224 72 mice mouse NNS cord-322899-uxvlagt3 224 73 Rapid Rapid NNP cord-322899-uxvlagt3 224 74 genomic genomic JJ cord-322899-uxvlagt3 224 75 evolution evolution NN cord-322899-uxvlagt3 224 76 of of IN cord-322899-uxvlagt3 224 77 a a DT cord-322899-uxvlagt3 224 78 non non JJ cord-322899-uxvlagt3 224 79 - - JJ cord-322899-uxvlagt3 224 80 virulent virulent JJ cord-322899-uxvlagt3 224 81 coxsackievirus coxsackievirus NN cord-322899-uxvlagt3 224 82 B3 b3 NN cord-322899-uxvlagt3 224 83 in in IN cord-322899-uxvlagt3 224 84 selenium selenium NN cord-322899-uxvlagt3 224 85 - - HYPH cord-322899-uxvlagt3 224 86 deficient deficient JJ cord-322899-uxvlagt3 224 87 mice mice NN cord-322899-uxvlagt3 224 88 results result NNS cord-322899-uxvlagt3 224 89 in in IN cord-322899-uxvlagt3 224 90 selection selection NN cord-322899-uxvlagt3 224 91 of of IN cord-322899-uxvlagt3 224 92 identical identical JJ cord-322899-uxvlagt3 224 93 virulent virulent JJ cord-322899-uxvlagt3 224 94 isolates isolate NNS cord-322899-uxvlagt3 225 1 The the DT cord-322899-uxvlagt3 225 2 immune immune JJ cord-322899-uxvlagt3 225 3 response response NN cord-322899-uxvlagt3 225 4 to to IN cord-322899-uxvlagt3 225 5 herpes herpes NNP cord-322899-uxvlagt3 225 6 simplex simplex NNP cord-322899-uxvlagt3 225 7 virus virus NN cord-322899-uxvlagt3 225 8 encephalitis encephalitis RB cord-322899-uxvlagt3 225 9 in in IN cord-322899-uxvlagt3 225 10 mice mouse NNS cord-322899-uxvlagt3 225 11 is be VBZ cord-322899-uxvlagt3 225 12 modulated modulate VBN cord-322899-uxvlagt3 225 13 by by IN cord-322899-uxvlagt3 225 14 dietary dietary JJ cord-322899-uxvlagt3 225 15 vitamin vitamin NN cord-322899-uxvlagt3 225 16 E e NN cord-322899-uxvlagt3 225 17 Effect effect NN cord-322899-uxvlagt3 225 18 of of IN cord-322899-uxvlagt3 225 19 vitamin vitamin NN cord-322899-uxvlagt3 225 20 E e NN cord-322899-uxvlagt3 225 21 supplementation supplementation NN cord-322899-uxvlagt3 225 22 on on IN cord-322899-uxvlagt3 225 23 lipid lipid NN cord-322899-uxvlagt3 225 24 peroxidation peroxidation NN cord-322899-uxvlagt3 225 25 in in IN cord-322899-uxvlagt3 225 26 blood blood NN cord-322899-uxvlagt3 225 27 and and CC cord-322899-uxvlagt3 225 28 lung lung NN cord-322899-uxvlagt3 225 29 of of IN cord-322899-uxvlagt3 225 30 influenza influenza NN cord-322899-uxvlagt3 225 31 virus virus NN cord-322899-uxvlagt3 225 32 infected infect VBN cord-322899-uxvlagt3 225 33 mice mouse NNS cord-322899-uxvlagt3 225 34 E e NN cord-322899-uxvlagt3 225 35 deficiency deficiency NN cord-322899-uxvlagt3 225 36 and and CC cord-322899-uxvlagt3 225 37 lipoperoxidation lipoperoxidation NN cord-322899-uxvlagt3 225 38 during during IN cord-322899-uxvlagt3 225 39 adult adult JJ cord-322899-uxvlagt3 225 40 respiratory respiratory JJ cord-322899-uxvlagt3 225 41 distress distress NN cord-322899-uxvlagt3 225 42 syndrome syndrome NN cord-322899-uxvlagt3 225 43 Randomized randomized JJ cord-322899-uxvlagt3 225 44 , , , cord-322899-uxvlagt3 225 45 prospective prospective JJ cord-322899-uxvlagt3 225 46 trial trial NN cord-322899-uxvlagt3 225 47 of of IN cord-322899-uxvlagt3 225 48 antioxidant antioxidant JJ cord-322899-uxvlagt3 225 49 supplementation supplementation NN cord-322899-uxvlagt3 225 50 in in IN cord-322899-uxvlagt3 225 51 critically critically RB cord-322899-uxvlagt3 225 52 ill ill JJ cord-322899-uxvlagt3 225 53 surgical surgical JJ cord-322899-uxvlagt3 225 54 patients patient NNS cord-322899-uxvlagt3 225 55 Prevalence prevalence NN cord-322899-uxvlagt3 225 56 of of IN cord-322899-uxvlagt3 225 57 comorbidities comorbiditie NNS cord-322899-uxvlagt3 225 58 in in IN cord-322899-uxvlagt3 225 59 the the DT cord-322899-uxvlagt3 225 60 novel novel JJ cord-322899-uxvlagt3 225 61 Wuhan Wuhan NNP cord-322899-uxvlagt3 225 62 coronavirus coronavirus NN cord-322899-uxvlagt3 225 63 ( ( -LRB- cord-322899-uxvlagt3 225 64 COVID-19 covid-19 VB cord-322899-uxvlagt3 225 65 ) ) -RRB- cord-322899-uxvlagt3 225 66 infection infection NN cord-322899-uxvlagt3 225 67 : : : cord-322899-uxvlagt3 225 68 a a DT cord-322899-uxvlagt3 225 69 systematic systematic JJ cord-322899-uxvlagt3 225 70 review review NN cord-322899-uxvlagt3 225 71 and and CC cord-322899-uxvlagt3 225 72 meta meta NNP cord-322899-uxvlagt3 225 73 - - HYPH cord-322899-uxvlagt3 225 74 analysis analysis NN cord-322899-uxvlagt3 225 75 Host host NN cord-322899-uxvlagt3 225 76 susceptibility susceptibility NN cord-322899-uxvlagt3 225 77 to to IN cord-322899-uxvlagt3 225 78 severe severe JJ cord-322899-uxvlagt3 225 79 COVID-19 covid-19 NN cord-322899-uxvlagt3 225 80 and and CC cord-322899-uxvlagt3 225 81 establishment establishment NN cord-322899-uxvlagt3 225 82 of of IN cord-322899-uxvlagt3 225 83 a a DT cord-322899-uxvlagt3 225 84 host host NN cord-322899-uxvlagt3 225 85 risk risk NN cord-322899-uxvlagt3 225 86 score score NN cord-322899-uxvlagt3 225 87 : : : cord-322899-uxvlagt3 225 88 findings finding NNS cord-322899-uxvlagt3 225 89 of of IN cord-322899-uxvlagt3 225 90 487 487 CD cord-322899-uxvlagt3 225 91 cases case NNS cord-322899-uxvlagt3 225 92 outside outside IN cord-322899-uxvlagt3 225 93 Wuhan Wuhan NNP cord-322899-uxvlagt3 225 94 Evidence Evidence NNP cord-322899-uxvlagt3 225 95 - - HYPH cord-322899-uxvlagt3 225 96 based base VBN cord-322899-uxvlagt3 225 97 nutritional nutritional JJ cord-322899-uxvlagt3 225 98 and and CC cord-322899-uxvlagt3 225 99 pharmacological pharmacological JJ cord-322899-uxvlagt3 225 100 interventions intervention NNS cord-322899-uxvlagt3 225 101 targeting target VBG cord-322899-uxvlagt3 225 102 chronic chronic JJ cord-322899-uxvlagt3 225 103 low low JJ cord-322899-uxvlagt3 225 104 - - HYPH cord-322899-uxvlagt3 225 105 grade grade NN cord-322899-uxvlagt3 225 106 inflammation inflammation NN cord-322899-uxvlagt3 225 107 in in IN cord-322899-uxvlagt3 225 108 middle middle JJ cord-322899-uxvlagt3 225 109 - - HYPH cord-322899-uxvlagt3 225 110 age age NN cord-322899-uxvlagt3 225 111 and and CC cord-322899-uxvlagt3 225 112 older old JJR cord-322899-uxvlagt3 225 113 adults adult NNS cord-322899-uxvlagt3 225 114 : : : cord-322899-uxvlagt3 225 115 A a DT cord-322899-uxvlagt3 225 116 systematic systematic JJ cord-322899-uxvlagt3 225 117 review review NN cord-322899-uxvlagt3 225 118 and and CC cord-322899-uxvlagt3 225 119 meta meta NNP cord-322899-uxvlagt3 225 120 - - HYPH cord-322899-uxvlagt3 225 121 analysis analysis NN cord-322899-uxvlagt3 225 122 Aging aging NN cord-322899-uxvlagt3 225 123 , , , cord-322899-uxvlagt3 225 124 Immunity Immunity NNP cord-322899-uxvlagt3 225 125 , , , cord-322899-uxvlagt3 225 126 and and CC cord-322899-uxvlagt3 225 127 Infection Infection NNP cord-322899-uxvlagt3 225 128 Inflamm Inflamm NNP cord-322899-uxvlagt3 225 129 - - HYPH cord-322899-uxvlagt3 225 130 ageing age VBG cord-322899-uxvlagt3 225 131 and and CC cord-322899-uxvlagt3 225 132 lifelong lifelong JJ cord-322899-uxvlagt3 225 133 antigenic antigenic JJ cord-322899-uxvlagt3 225 134 load load NN cord-322899-uxvlagt3 225 135 as as IN cord-322899-uxvlagt3 225 136 major major JJ cord-322899-uxvlagt3 225 137 determinants determinant NNS cord-322899-uxvlagt3 225 138 of of IN cord-322899-uxvlagt3 225 139 ageing age VBG cord-322899-uxvlagt3 225 140 rate rate NN cord-322899-uxvlagt3 225 141 and and CC cord-322899-uxvlagt3 225 142 longevity longevity NN cord-322899-uxvlagt3 225 143 Nutrition nutrition NN cord-322899-uxvlagt3 225 144 , , , cord-322899-uxvlagt3 225 145 diet diet NN cord-322899-uxvlagt3 225 146 and and CC cord-322899-uxvlagt3 225 147 immunosenescence immunosenescence JJ cord-322899-uxvlagt3 225 148 Physiological physiological JJ cord-322899-uxvlagt3 225 149 role role NN cord-322899-uxvlagt3 225 150 of of IN cord-322899-uxvlagt3 225 151 antioxidants antioxidant NNS cord-322899-uxvlagt3 225 152 in in IN cord-322899-uxvlagt3 225 153 the the DT cord-322899-uxvlagt3 225 154 immune immune JJ cord-322899-uxvlagt3 225 155 system system NN cord-322899-uxvlagt3 225 156 World World NNP cord-322899-uxvlagt3 225 157 Health Health NNP cord-322899-uxvlagt3 225 158 Organization Organization NNP cord-322899-uxvlagt3 225 159 , , , cord-322899-uxvlagt3 225 160 Food Food NNP cord-322899-uxvlagt3 225 161 and and CC cord-322899-uxvlagt3 225 162 Agricultural Agricultural NNP cord-322899-uxvlagt3 225 163 Organization Organization NNP cord-322899-uxvlagt3 225 164 of of IN cord-322899-uxvlagt3 225 165 the the DT cord-322899-uxvlagt3 225 166 United United NNP cord-322899-uxvlagt3 225 167 Nations Nations NNP cord-322899-uxvlagt3 225 168 . . . cord-322899-uxvlagt3 226 1 Guidelines guideline NNS cord-322899-uxvlagt3 226 2 on on IN cord-322899-uxvlagt3 226 3 food food NN cord-322899-uxvlagt3 226 4 fortification fortification NN cord-322899-uxvlagt3 226 5 with with IN cord-322899-uxvlagt3 226 6 micronutrients micronutrient NNS cord-322899-uxvlagt3 227 1 The the DT cord-322899-uxvlagt3 227 2 interaction interaction NN cord-322899-uxvlagt3 227 3 between between IN cord-322899-uxvlagt3 227 4 nutrition nutrition NN cord-322899-uxvlagt3 227 5 and and CC cord-322899-uxvlagt3 227 6 infection infection NN cord-322899-uxvlagt3 227 7 Effects effect NNS cord-322899-uxvlagt3 227 8 of of IN cord-322899-uxvlagt3 227 9 widely widely RB cord-322899-uxvlagt3 227 10 used use VBN cord-322899-uxvlagt3 227 11 drugs drug NNS cord-322899-uxvlagt3 227 12 on on IN cord-322899-uxvlagt3 227 13 micronutrients micronutrient NNS cord-322899-uxvlagt3 227 14 : : : cord-322899-uxvlagt3 227 15 a a DT cord-322899-uxvlagt3 227 16 story story NN cord-322899-uxvlagt3 227 17 rarely rarely RB cord-322899-uxvlagt3 227 18 told tell VBD cord-322899-uxvlagt3 227 19 Dairy dairy NN cord-322899-uxvlagt3 227 20 products product NNS cord-322899-uxvlagt3 227 21 and and CC cord-322899-uxvlagt3 227 22 inflammation inflammation NN cord-322899-uxvlagt3 227 23 : : : cord-322899-uxvlagt3 227 24 A a DT cord-322899-uxvlagt3 227 25 review review NN cord-322899-uxvlagt3 227 26 of of IN cord-322899-uxvlagt3 227 27 the the DT cord-322899-uxvlagt3 227 28 clinical clinical JJ cord-322899-uxvlagt3 227 29 evidence evidence NN cord-322899-uxvlagt3 227 30 Nutrition Nutrition NNP cord-322899-uxvlagt3 227 31 and and CC cord-322899-uxvlagt3 227 32 the the DT cord-322899-uxvlagt3 227 33 immune immune JJ cord-322899-uxvlagt3 227 34 system system NN cord-322899-uxvlagt3 227 35 from from IN cord-322899-uxvlagt3 227 36 birth birth NN cord-322899-uxvlagt3 227 37 to to IN cord-322899-uxvlagt3 227 38 old old JJ cord-322899-uxvlagt3 227 39 age age NN cord-322899-uxvlagt3 227 40 Effects effect NNS cord-322899-uxvlagt3 227 41 of of IN cord-322899-uxvlagt3 227 42 the the DT cord-322899-uxvlagt3 227 43 association association NN cord-322899-uxvlagt3 227 44 of of IN cord-322899-uxvlagt3 227 45 aging age VBG cord-322899-uxvlagt3 227 46 and and CC cord-322899-uxvlagt3 227 47 obesity obesity NN cord-322899-uxvlagt3 227 48 on on IN cord-322899-uxvlagt3 227 49 lipids lipid NNS cord-322899-uxvlagt3 227 50 , , , cord-322899-uxvlagt3 227 51 lipoproteins lipoprotein NNS cord-322899-uxvlagt3 227 52 and and CC cord-322899-uxvlagt3 227 53 oxidative oxidative JJ cord-322899-uxvlagt3 227 54 stress stress NN cord-322899-uxvlagt3 227 55 biomarkers biomarker NNS cord-322899-uxvlagt3 227 56 : : : cord-322899-uxvlagt3 227 57 A a DT cord-322899-uxvlagt3 227 58 comparison comparison NN cord-322899-uxvlagt3 227 59 of of IN cord-322899-uxvlagt3 227 60 older old JJR cord-322899-uxvlagt3 227 61 with with IN cord-322899-uxvlagt3 227 62 young young JJ cord-322899-uxvlagt3 227 63 men man NNS cord-322899-uxvlagt3 228 1 A a DT cord-322899-uxvlagt3 228 2 systematic systematic JJ cord-322899-uxvlagt3 228 3 review review NN cord-322899-uxvlagt3 228 4 of of IN cord-322899-uxvlagt3 228 5 vitamin vitamin NN cord-322899-uxvlagt3 228 6 D d NN cord-322899-uxvlagt3 228 7 status status NN cord-322899-uxvlagt3 228 8 in in IN cord-322899-uxvlagt3 228 9 southern southern JJ cord-322899-uxvlagt3 228 10 European european JJ cord-322899-uxvlagt3 228 11 countries country NNS cord-322899-uxvlagt3 228 12 Nutritional nutritional JJ cord-322899-uxvlagt3 228 13 challenges challenge NNS cord-322899-uxvlagt3 228 14 for for IN cord-322899-uxvlagt3 228 15 older old JJR cord-322899-uxvlagt3 228 16 adults adult NNS cord-322899-uxvlagt3 228 17 in in IN cord-322899-uxvlagt3 228 18 Europe Europe NNP cord-322899-uxvlagt3 228 19 : : : cord-322899-uxvlagt3 228 20 current current JJ cord-322899-uxvlagt3 228 21 status status NN cord-322899-uxvlagt3 228 22 and and CC cord-322899-uxvlagt3 228 23 future future JJ cord-322899-uxvlagt3 228 24 directions direction NNS cord-322899-uxvlagt3 228 25 Association Association NNP cord-322899-uxvlagt3 228 26 between between IN cord-322899-uxvlagt3 228 27 solar solar JJ cord-322899-uxvlagt3 228 28 ultraviolet ultraviolet JJ cord-322899-uxvlagt3 228 29 doses dose NNS cord-322899-uxvlagt3 228 30 and and CC cord-322899-uxvlagt3 228 31 vitamin vitamin NN cord-322899-uxvlagt3 228 32 D d NN cord-322899-uxvlagt3 228 33 clinical clinical JJ cord-322899-uxvlagt3 228 34 routine routine JJ cord-322899-uxvlagt3 228 35 data datum NNS cord-322899-uxvlagt3 228 36 in in IN cord-322899-uxvlagt3 228 37 European european JJ cord-322899-uxvlagt3 228 38 mid mid JJ cord-322899-uxvlagt3 228 39 - - JJ cord-322899-uxvlagt3 228 40 latitude latitude JJ cord-322899-uxvlagt3 228 41 population population NN cord-322899-uxvlagt3 228 42 between between IN cord-322899-uxvlagt3 228 43 Air air NN cord-322899-uxvlagt3 228 44 pollution pollution NN cord-322899-uxvlagt3 228 45 exposure exposure NN cord-322899-uxvlagt3 228 46 , , , cord-322899-uxvlagt3 228 47 causespecific causespecific JJ cord-322899-uxvlagt3 228 48 deaths death NNS cord-322899-uxvlagt3 228 49 and and CC cord-322899-uxvlagt3 228 50 hospitalizations hospitalization NNS cord-322899-uxvlagt3 228 51 in in IN cord-322899-uxvlagt3 228 52 a a DT cord-322899-uxvlagt3 228 53 highly highly RB cord-322899-uxvlagt3 228 54 polluted polluted JJ cord-322899-uxvlagt3 228 55 Italian italian JJ cord-322899-uxvlagt3 228 56 region region NN cord-322899-uxvlagt3 228 57 Sunlight sunlight NN cord-322899-uxvlagt3 228 58 and and CC cord-322899-uxvlagt3 228 59 Vitamin vitamin NN cord-322899-uxvlagt3 228 60 D d NN cord-322899-uxvlagt3 228 61 : : : cord-322899-uxvlagt3 228 62 A a DT cord-322899-uxvlagt3 228 63 global global JJ cord-322899-uxvlagt3 228 64 perspective perspective NN cord-322899-uxvlagt3 228 65 for for IN cord-322899-uxvlagt3 228 66 health health NN cord-322899-uxvlagt3 228 67 Zinc zinc NN cord-322899-uxvlagt3 228 68 and and CC cord-322899-uxvlagt3 228 69 selenium selenium NN cord-322899-uxvlagt3 228 70 indicators indicator NNS cord-322899-uxvlagt3 228 71 and and CC cord-322899-uxvlagt3 228 72 their -PRON- PRP$ cord-322899-uxvlagt3 228 73 relation relation NN cord-322899-uxvlagt3 228 74 to to IN cord-322899-uxvlagt3 228 75 immunologic immunologic JJ cord-322899-uxvlagt3 228 76 and and CC cord-322899-uxvlagt3 228 77 metabolic metabolic JJ cord-322899-uxvlagt3 228 78 parameters parameter NNS cord-322899-uxvlagt3 228 79 in in IN cord-322899-uxvlagt3 228 80 male male JJ cord-322899-uxvlagt3 228 81 patients patient NNS cord-322899-uxvlagt3 228 82 with with IN cord-322899-uxvlagt3 228 83 human human JJ cord-322899-uxvlagt3 228 84 immunodeficiency immunodeficiency NN cord-322899-uxvlagt3 228 85 virus virus NN cord-322899-uxvlagt3 228 86 Vitamin vitamin NN cord-322899-uxvlagt3 228 87 C C NNP cord-322899-uxvlagt3 228 88 as as IN cord-322899-uxvlagt3 228 89 prophylaxis prophylaxis NN cord-322899-uxvlagt3 228 90 and and CC cord-322899-uxvlagt3 228 91 adjunctive adjunctive JJ cord-322899-uxvlagt3 228 92 medical medical JJ cord-322899-uxvlagt3 228 93 treatment treatment NN cord-322899-uxvlagt3 228 94 for for IN cord-322899-uxvlagt3 228 95 COVID-19 COVID-19 NNP cord-322899-uxvlagt3 228 96 ? ? . cord-322899-uxvlagt3 229 1 Effect effect NN cord-322899-uxvlagt3 229 2 of of IN cord-322899-uxvlagt3 229 3 routine routine JJ cord-322899-uxvlagt3 229 4 zinc zinc NN cord-322899-uxvlagt3 229 5 supplementation supplementation NN cord-322899-uxvlagt3 229 6 on on IN cord-322899-uxvlagt3 229 7 pneumonia pneumonia NN cord-322899-uxvlagt3 229 8 in in IN cord-322899-uxvlagt3 229 9 children child NNS cord-322899-uxvlagt3 229 10 aged age VBN cord-322899-uxvlagt3 229 11 6 6 CD cord-322899-uxvlagt3 229 12 months month NNS cord-322899-uxvlagt3 229 13 to to IN cord-322899-uxvlagt3 229 14 3 3 CD cord-322899-uxvlagt3 229 15 years year NNS cord-322899-uxvlagt3 229 16 : : : cord-322899-uxvlagt3 229 17 randomised randomised JJ cord-322899-uxvlagt3 229 18 controlled control VBN cord-322899-uxvlagt3 229 19 trial trial NN cord-322899-uxvlagt3 229 20 in in IN cord-322899-uxvlagt3 229 21 an an DT cord-322899-uxvlagt3 229 22 urban urban JJ cord-322899-uxvlagt3 229 23 slum slum NN cord-322899-uxvlagt3 229 24 Zinc zinc NN cord-322899-uxvlagt3 229 25 for for IN cord-322899-uxvlagt3 229 26 the the DT cord-322899-uxvlagt3 229 27 treatment treatment NN cord-322899-uxvlagt3 229 28 of of IN cord-322899-uxvlagt3 229 29 the the DT cord-322899-uxvlagt3 229 30 common common JJ cord-322899-uxvlagt3 229 31 cold cold NN cord-322899-uxvlagt3 229 32 : : : cord-322899-uxvlagt3 229 33 a a DT cord-322899-uxvlagt3 229 34 systematic systematic JJ cord-322899-uxvlagt3 229 35 review review NN cord-322899-uxvlagt3 229 36 and and CC cord-322899-uxvlagt3 229 37 meta meta NNP cord-322899-uxvlagt3 229 38 - - HYPH cord-322899-uxvlagt3 229 39 analysis analysis NN cord-322899-uxvlagt3 229 40 of of IN cord-322899-uxvlagt3 229 41 randomized randomized JJ cord-322899-uxvlagt3 229 42 controlled control VBN cord-322899-uxvlagt3 229 43 trials trial NNS cord-322899-uxvlagt3 229 44 Combating combat VBG cord-322899-uxvlagt3 229 45 Micronutrient Micronutrient NNP cord-322899-uxvlagt3 229 46 Deficiencies deficiency NNS cord-322899-uxvlagt3 229 47 : : : cord-322899-uxvlagt3 230 1 Foodbased Foodbased NNP cord-322899-uxvlagt3 230 2 Approaches approach NNS cord-322899-uxvlagt3 231 1 Vitamin vitamin NN cord-322899-uxvlagt3 231 2 A a DT cord-322899-uxvlagt3 231 3 Supplementation supplementation NN cord-322899-uxvlagt3 231 4 Was be VBD cord-322899-uxvlagt3 231 5 Associated associate VBN cord-322899-uxvlagt3 231 6 with with IN cord-322899-uxvlagt3 231 7 Reduced reduce VBN cord-322899-uxvlagt3 231 8 Mortality mortality NN cord-322899-uxvlagt3 231 9 in in IN cord-322899-uxvlagt3 231 10 Patients patient NNS cord-322899-uxvlagt3 231 11 with with IN cord-322899-uxvlagt3 231 12 Ebola Ebola NNP cord-322899-uxvlagt3 231 13 Virus Virus NNP cord-322899-uxvlagt3 231 14 Disease Disease NNP cord-322899-uxvlagt3 231 15 during during IN cord-322899-uxvlagt3 231 16 the the DT cord-322899-uxvlagt3 231 17 West west JJ cord-322899-uxvlagt3 231 18 African african JJ cord-322899-uxvlagt3 231 19 Outbreak outbreak NN cord-322899-uxvlagt3 231 20 Influence influence NN cord-322899-uxvlagt3 231 21 of of IN cord-322899-uxvlagt3 231 22 a a DT cord-322899-uxvlagt3 231 23 complex complex JJ cord-322899-uxvlagt3 231 24 micronutrient micronutrient NN cord-322899-uxvlagt3 231 25 supplement supplement NN cord-322899-uxvlagt3 231 26 on on IN cord-322899-uxvlagt3 231 27 the the DT cord-322899-uxvlagt3 231 28 immune immune JJ cord-322899-uxvlagt3 231 29 status status NN cord-322899-uxvlagt3 231 30 of of IN cord-322899-uxvlagt3 231 31 elderly elderly JJ cord-322899-uxvlagt3 231 32 individuals individual NNS cord-322899-uxvlagt3 231 33 Drug drug NN cord-322899-uxvlagt3 231 34 - - HYPH cord-322899-uxvlagt3 231 35 micronutrient micronutrient NN cord-322899-uxvlagt3 231 36 interactions interaction NNS cord-322899-uxvlagt3 231 37 : : : cord-322899-uxvlagt3 231 38 food food NN cord-322899-uxvlagt3 231 39 for for IN cord-322899-uxvlagt3 231 40 thought thought NN cord-322899-uxvlagt3 231 41 and and CC cord-322899-uxvlagt3 231 42 thought think VBD cord-322899-uxvlagt3 231 43 for for IN cord-322899-uxvlagt3 231 44 action action NN cord-322899-uxvlagt3 231 45 High high JJ cord-322899-uxvlagt3 231 46 antibiotic antibiotic JJ cord-322899-uxvlagt3 231 47 consumption consumption NN cord-322899-uxvlagt3 231 48 : : : cord-322899-uxvlagt3 231 49 a a DT cord-322899-uxvlagt3 231 50 characterization characterization NN cord-322899-uxvlagt3 231 51 of of IN cord-322899-uxvlagt3 231 52 heavy heavy JJ cord-322899-uxvlagt3 231 53 users user NNS cord-322899-uxvlagt3 231 54 in in IN cord-322899-uxvlagt3 231 55 Spain Spain NNP cord-322899-uxvlagt3 231 56 Antibiotic Antibiotic NNP cord-322899-uxvlagt3 231 57 Consumption Consumption NNP cord-322899-uxvlagt3 231 58 and and CC cord-322899-uxvlagt3 231 59 Resistance Resistance NNP cord-322899-uxvlagt3 231 60 during during IN cord-322899-uxvlagt3 231 61 a a DT cord-322899-uxvlagt3 231 62 3-Year 3-Year NNP cord-322899-uxvlagt3 231 63 Period Period NNP cord-322899-uxvlagt3 231 64 in in IN cord-322899-uxvlagt3 231 65 Sicily Sicily NNP cord-322899-uxvlagt3 232 1 , , , cord-322899-uxvlagt3 232 2 Southern Southern NNP cord-322899-uxvlagt3 232 3 Italy Italy NNP cord-322899-uxvlagt3 232 4 Microbiota Microbiota NNP cord-322899-uxvlagt3 232 5 regulates regulate VBZ cord-322899-uxvlagt3 232 6 immune immune JJ cord-322899-uxvlagt3 232 7 defense defense NN cord-322899-uxvlagt3 232 8 against against IN cord-322899-uxvlagt3 232 9 respiratory respiratory JJ cord-322899-uxvlagt3 232 10 tract tract NN cord-322899-uxvlagt3 232 11 influenza influenza NN cord-322899-uxvlagt3 232 12 A a DT cord-322899-uxvlagt3 232 13 virus virus NN cord-322899-uxvlagt3 232 14 infection infection NN cord-322899-uxvlagt3 232 15 Cuban cuban JJ cord-322899-uxvlagt3 232 16 epidemic epidemic NN cord-322899-uxvlagt3 232 17 neuropathy neuropathy NN cord-322899-uxvlagt3 232 18 . . . cord-322899-uxvlagt3 233 1 II II NNP cord-322899-uxvlagt3 233 2 . . . cord-322899-uxvlagt3 234 1 The the DT cord-322899-uxvlagt3 234 2 antigenic antigenic JJ cord-322899-uxvlagt3 234 3 characteristics characteristic NNS cord-322899-uxvlagt3 234 4 of of IN cord-322899-uxvlagt3 234 5 the the DT cord-322899-uxvlagt3 234 6 viral viral JJ cord-322899-uxvlagt3 234 7 isolates isolate NNS cord-322899-uxvlagt3 234 8 Food Food NNP cord-322899-uxvlagt3 234 9 supplementation supplementation NN cord-322899-uxvlagt3 234 10 among among IN cord-322899-uxvlagt3 234 11 HIV HIV NNP cord-322899-uxvlagt3 234 12 - - HYPH cord-322899-uxvlagt3 234 13 infected infect VBN cord-322899-uxvlagt3 234 14 adults adult NNS cord-322899-uxvlagt3 234 15 in in IN cord-322899-uxvlagt3 234 16 Sub Sub NNP cord-322899-uxvlagt3 234 17 - - HYPH cord-322899-uxvlagt3 234 18 Saharan Saharan NNP cord-322899-uxvlagt3 234 19 Africa Africa NNP cord-322899-uxvlagt3 234 20 : : : cord-322899-uxvlagt3 234 21 impact impact NN cord-322899-uxvlagt3 234 22 on on IN cord-322899-uxvlagt3 234 23 treatment treatment NN cord-322899-uxvlagt3 234 24 adherence adherence NN cord-322899-uxvlagt3 234 25 and and CC cord-322899-uxvlagt3 234 26 weight weight NN cord-322899-uxvlagt3 234 27 gain gain NN cord-322899-uxvlagt3 234 28 The the DT cord-322899-uxvlagt3 234 29 authors author NNS cord-322899-uxvlagt3 234 30 declare declare VBP cord-322899-uxvlagt3 234 31 that that IN cord-322899-uxvlagt3 234 32 they -PRON- PRP cord-322899-uxvlagt3 234 33 have have VBP cord-322899-uxvlagt3 234 34 no no DT cord-322899-uxvlagt3 234 35 known know VBN cord-322899-uxvlagt3 234 36 competing compete VBG cord-322899-uxvlagt3 234 37 financial financial JJ cord-322899-uxvlagt3 234 38 interests interest NNS cord-322899-uxvlagt3 234 39 or or CC cord-322899-uxvlagt3 234 40 personal personal JJ cord-322899-uxvlagt3 234 41 relationships relationship NNS cord-322899-uxvlagt3 234 42 that that WDT cord-322899-uxvlagt3 234 43 could could MD cord-322899-uxvlagt3 234 44 have have VB cord-322899-uxvlagt3 234 45 appeared appear VBN cord-322899-uxvlagt3 234 46 to to TO cord-322899-uxvlagt3 234 47 influence influence VB cord-322899-uxvlagt3 234 48 the the DT cord-322899-uxvlagt3 234 49 work work NN cord-322899-uxvlagt3 234 50 reported report VBN cord-322899-uxvlagt3 234 51 in in IN cord-322899-uxvlagt3 234 52 this this DT cord-322899-uxvlagt3 234 53 paper paper NN cord-322899-uxvlagt3 234 54 . . .