id sid tid token lemma pos cord-271653-4q2olzx1 1 1 key key JJ cord-271653-4q2olzx1 2 1 : : : cord-271653-4q2olzx1 2 2 cord-271653 cord-271653 NNP cord-271653-4q2olzx1 2 3 - - HYPH cord-271653-4q2olzx1 2 4 4q2olzx1 4q2olzx1 CD cord-271653-4q2olzx1 2 5 authors author NNS cord-271653-4q2olzx1 2 6 : : : cord-271653-4q2olzx1 2 7 Libby Libby NNP cord-271653-4q2olzx1 2 8 , , , cord-271653-4q2olzx1 2 9 Peter Peter NNP cord-271653-4q2olzx1 2 10 title title NN cord-271653-4q2olzx1 2 11 : : : cord-271653-4q2olzx1 2 12 The the DT cord-271653-4q2olzx1 2 13 Heart heart NN cord-271653-4q2olzx1 2 14 in in IN cord-271653-4q2olzx1 2 15 COVID19 covid19 NN cord-271653-4q2olzx1 2 16 : : : cord-271653-4q2olzx1 2 17 Primary Primary NNP cord-271653-4q2olzx1 2 18 Target Target NNP cord-271653-4q2olzx1 2 19 or or CC cord-271653-4q2olzx1 2 20 Secondary secondary JJ cord-271653-4q2olzx1 2 21 Bystander Bystander NNP cord-271653-4q2olzx1 2 22 ? ? . cord-271653-4q2olzx1 3 1 date date NN cord-271653-4q2olzx1 3 2 : : : cord-271653-4q2olzx1 3 3 2020 2020 CD cord-271653-4q2olzx1 3 4 - - HYPH cord-271653-4q2olzx1 3 5 04 04 CD cord-271653-4q2olzx1 3 6 - - SYM cord-271653-4q2olzx1 3 7 10 10 CD cord-271653-4q2olzx1 3 8 journal journal NN cord-271653-4q2olzx1 3 9 : : : cord-271653-4q2olzx1 3 10 JACC JACC NNP cord-271653-4q2olzx1 3 11 Basic Basic NNP cord-271653-4q2olzx1 3 12 Transl Transl NNP cord-271653-4q2olzx1 4 1 Sci Sci NNP cord-271653-4q2olzx1 4 2 DOI DOI NNP cord-271653-4q2olzx1 4 3 : : : cord-271653-4q2olzx1 4 4 10.1016 10.1016 CD cord-271653-4q2olzx1 4 5 / / SYM cord-271653-4q2olzx1 4 6 j.jacbts.2020.04.001 j.jacbts.2020.04.001 XX cord-271653-4q2olzx1 4 7 sha sha NNP cord-271653-4q2olzx1 4 8 : : : cord-271653-4q2olzx1 4 9 e6eefd34cd7466463ab20f15d56ff5ef6e9a7bcc e6eefd34cd7466463ab20f15d56ff5ef6e9a7bcc NNP cord-271653-4q2olzx1 4 10 doc_id doc_id NNPS cord-271653-4q2olzx1 5 1 : : : cord-271653-4q2olzx1 5 2 271653 271653 CD cord-271653-4q2olzx1 5 3 cord_uid cord_uid NNS cord-271653-4q2olzx1 5 4 : : : cord-271653-4q2olzx1 6 1 4q2olzx1 4q2olzx1 CD cord-271653-4q2olzx1 7 1 Summary summary NN cord-271653-4q2olzx1 7 2 : : : cord-271653-4q2olzx1 8 1 In in IN cord-271653-4q2olzx1 8 2 the the DT cord-271653-4q2olzx1 8 3 throes throe NNS cord-271653-4q2olzx1 8 4 of of IN cord-271653-4q2olzx1 8 5 the the DT cord-271653-4q2olzx1 8 6 current current JJ cord-271653-4q2olzx1 8 7 COVID-19 COVID-19 NNP cord-271653-4q2olzx1 8 8 pandemic pandemic NN cord-271653-4q2olzx1 8 9 , , , cord-271653-4q2olzx1 8 10 interest interest NN cord-271653-4q2olzx1 8 11 has have VBZ cord-271653-4q2olzx1 8 12 burgeoned burgeon VBN cord-271653-4q2olzx1 8 13 in in IN cord-271653-4q2olzx1 8 14 the the DT cord-271653-4q2olzx1 8 15 cardiovascular cardiovascular JJ cord-271653-4q2olzx1 8 16 complications complication NNS cord-271653-4q2olzx1 8 17 of of IN cord-271653-4q2olzx1 8 18 this this DT cord-271653-4q2olzx1 8 19 virulent virulent JJ cord-271653-4q2olzx1 8 20 viral viral JJ cord-271653-4q2olzx1 8 21 infection infection NN cord-271653-4q2olzx1 8 22 . . . cord-271653-4q2olzx1 9 1 As as IN cord-271653-4q2olzx1 9 2 troponin troponin JJ cord-271653-4q2olzx1 9 3 , , , cord-271653-4q2olzx1 9 4 a a DT cord-271653-4q2olzx1 9 5 biomarker biomarker NN cord-271653-4q2olzx1 9 6 of of IN cord-271653-4q2olzx1 9 7 cardiac cardiac JJ cord-271653-4q2olzx1 9 8 injury injury NN cord-271653-4q2olzx1 9 9 , , , cord-271653-4q2olzx1 9 10 often often RB cord-271653-4q2olzx1 9 11 rises rise VBZ cord-271653-4q2olzx1 9 12 in in IN cord-271653-4q2olzx1 9 13 hospitalized hospitalize VBN cord-271653-4q2olzx1 9 14 patients patient NNS cord-271653-4q2olzx1 9 15 , , , cord-271653-4q2olzx1 9 16 its -PRON- PRP$ cord-271653-4q2olzx1 9 17 interpretation interpretation NN cord-271653-4q2olzx1 9 18 and and CC cord-271653-4q2olzx1 9 19 actionability actionability NN cord-271653-4q2olzx1 9 20 require require VBP cord-271653-4q2olzx1 9 21 careful careful JJ cord-271653-4q2olzx1 9 22 consideration consideration NN cord-271653-4q2olzx1 9 23 . . . cord-271653-4q2olzx1 10 1 Fulminant Fulminant NNP cord-271653-4q2olzx1 10 2 myocarditis myocarditis NN cord-271653-4q2olzx1 10 3 due due IN cord-271653-4q2olzx1 10 4 to to IN cord-271653-4q2olzx1 10 5 direct direct JJ cord-271653-4q2olzx1 10 6 viral viral JJ cord-271653-4q2olzx1 10 7 infection infection NN cord-271653-4q2olzx1 10 8 can can MD cord-271653-4q2olzx1 10 9 certainly certainly RB cord-271653-4q2olzx1 10 10 occur occur VB cord-271653-4q2olzx1 10 11 , , , cord-271653-4q2olzx1 10 12 but but CC cord-271653-4q2olzx1 10 13 patients patient NNS cord-271653-4q2olzx1 10 14 with with IN cord-271653-4q2olzx1 10 15 increased increase VBN cord-271653-4q2olzx1 10 16 oxygen oxygen NN cord-271653-4q2olzx1 10 17 demands demand NNS cord-271653-4q2olzx1 10 18 due due JJ cord-271653-4q2olzx1 10 19 to to IN cord-271653-4q2olzx1 10 20 tachycardia tachycardia NN cord-271653-4q2olzx1 10 21 and and CC cord-271653-4q2olzx1 10 22 fever fever NN cord-271653-4q2olzx1 10 23 , , , cord-271653-4q2olzx1 10 24 and and CC cord-271653-4q2olzx1 10 25 reduced reduce VBN cord-271653-4q2olzx1 10 26 oxygen oxygen NN cord-271653-4q2olzx1 10 27 delivery delivery NN cord-271653-4q2olzx1 10 28 due due JJ cord-271653-4q2olzx1 10 29 to to IN cord-271653-4q2olzx1 10 30 hypotension hypotension NN cord-271653-4q2olzx1 10 31 and and CC cord-271653-4q2olzx1 10 32 hypoxemia hypoxemia NN cord-271653-4q2olzx1 10 33 can can MD cord-271653-4q2olzx1 10 34 cause cause VB cord-271653-4q2olzx1 10 35 myocardial myocardial JJ cord-271653-4q2olzx1 10 36 injury injury NN cord-271653-4q2olzx1 10 37 indirectly indirectly RB cord-271653-4q2olzx1 10 38 . . . cord-271653-4q2olzx1 11 1 Cytokines cytokine NNS cord-271653-4q2olzx1 11 2 released release VBN cord-271653-4q2olzx1 11 3 during during IN cord-271653-4q2olzx1 11 4 the the DT cord-271653-4q2olzx1 11 5 acute acute JJ cord-271653-4q2olzx1 11 6 infection infection NN cord-271653-4q2olzx1 11 7 can can MD cord-271653-4q2olzx1 11 8 elicit elicit VB cord-271653-4q2olzx1 11 9 activation activation NN cord-271653-4q2olzx1 11 10 of of IN cord-271653-4q2olzx1 11 11 cells cell NNS cord-271653-4q2olzx1 11 12 within within IN cord-271653-4q2olzx1 11 13 pre pre JJ cord-271653-4q2olzx1 11 14 - - JJ cord-271653-4q2olzx1 11 15 existing existing JJ cord-271653-4q2olzx1 11 16 atherosclerotic atherosclerotic JJ cord-271653-4q2olzx1 11 17 lesions lesion NNS cord-271653-4q2olzx1 11 18 , , , cord-271653-4q2olzx1 11 19 augmenting augment VBG cord-271653-4q2olzx1 11 20 thrombotic thrombotic JJ cord-271653-4q2olzx1 11 21 risk risk NN cord-271653-4q2olzx1 11 22 and and CC cord-271653-4q2olzx1 11 23 risk risk NN cord-271653-4q2olzx1 11 24 of of IN cord-271653-4q2olzx1 11 25 ischemic ischemic JJ cord-271653-4q2olzx1 11 26 syndromes syndrome NNS cord-271653-4q2olzx1 11 27 . . . cord-271653-4q2olzx1 12 1 Moreover moreover RB cord-271653-4q2olzx1 12 2 , , , cord-271653-4q2olzx1 12 3 microvascular microvascular JJ cord-271653-4q2olzx1 12 4 activation activation NN cord-271653-4q2olzx1 12 5 by by IN cord-271653-4q2olzx1 12 6 cytokines cytokine NNS cord-271653-4q2olzx1 12 7 can can MD cord-271653-4q2olzx1 12 8 cause cause VB cord-271653-4q2olzx1 12 9 not not RB cord-271653-4q2olzx1 12 10 only only RB cord-271653-4q2olzx1 12 11 myocardial myocardial JJ cord-271653-4q2olzx1 12 12 injury injury NN cord-271653-4q2olzx1 12 13 but but CC cord-271653-4q2olzx1 12 14 harm harm NN cord-271653-4q2olzx1 12 15 other other JJ cord-271653-4q2olzx1 12 16 organ organ NN cord-271653-4q2olzx1 12 17 systems system NNS cord-271653-4q2olzx1 12 18 commonly commonly RB cord-271653-4q2olzx1 12 19 involved involve VBN cord-271653-4q2olzx1 12 20 in in IN cord-271653-4q2olzx1 12 21 COVID-19 covid-19 JJ cord-271653-4q2olzx1 12 22 infections infection NNS cord-271653-4q2olzx1 12 23 including include VBG cord-271653-4q2olzx1 12 24 the the DT cord-271653-4q2olzx1 12 25 kidneys kidney NNS cord-271653-4q2olzx1 12 26 . . . cord-271653-4q2olzx1 13 1 Dealing deal VBG cord-271653-4q2olzx1 13 2 with with IN cord-271653-4q2olzx1 13 3 the the DT cord-271653-4q2olzx1 13 4 immense immense JJ cord-271653-4q2olzx1 13 5 challenge challenge NN cord-271653-4q2olzx1 13 6 of of IN cord-271653-4q2olzx1 13 7 COVID-19 COVID-19 NNP cord-271653-4q2olzx1 13 8 disease disease NN cord-271653-4q2olzx1 13 9 , , , cord-271653-4q2olzx1 13 10 confronted confront VBN cord-271653-4q2olzx1 13 11 with with IN cord-271653-4q2olzx1 13 12 severely severely RB cord-271653-4q2olzx1 13 13 ill ill JJ cord-271653-4q2olzx1 13 14 patients patient NNS cord-271653-4q2olzx1 13 15 in in IN cord-271653-4q2olzx1 13 16 dire dire JJ cord-271653-4q2olzx1 13 17 straits strait NNS cord-271653-4q2olzx1 13 18 with with IN cord-271653-4q2olzx1 13 19 virtually virtually RB cord-271653-4q2olzx1 13 20 no no DT cord-271653-4q2olzx1 13 21 rigorous rigorous JJ cord-271653-4q2olzx1 13 22 evidence evidence NN cord-271653-4q2olzx1 13 23 base base NN cord-271653-4q2olzx1 13 24 to to TO cord-271653-4q2olzx1 13 25 guide guide VB cord-271653-4q2olzx1 13 26 our -PRON- PRP$ cord-271653-4q2olzx1 13 27 therapy therapy NN cord-271653-4q2olzx1 13 28 , , , cord-271653-4q2olzx1 13 29 we -PRON- PRP cord-271653-4q2olzx1 13 30 must must MD cord-271653-4q2olzx1 13 31 call call VB cord-271653-4q2olzx1 13 32 upon upon IN cord-271653-4q2olzx1 13 33 our -PRON- PRP$ cord-271653-4q2olzx1 13 34 clinical clinical JJ cord-271653-4q2olzx1 13 35 skills skill NNS cord-271653-4q2olzx1 13 36 and and CC cord-271653-4q2olzx1 13 37 judgment judgment NN cord-271653-4q2olzx1 13 38 . . . cord-271653-4q2olzx1 14 1 These these DT cord-271653-4q2olzx1 14 2 touchstones touchstone NNS cord-271653-4q2olzx1 14 3 can can MD cord-271653-4q2olzx1 14 4 help help VB cord-271653-4q2olzx1 14 5 guide guide VB cord-271653-4q2olzx1 14 6 us -PRON- PRP cord-271653-4q2olzx1 14 7 in in IN cord-271653-4q2olzx1 14 8 selecting select VBG cord-271653-4q2olzx1 14 9 patients patient NNS cord-271653-4q2olzx1 14 10 who who WP cord-271653-4q2olzx1 14 11 might may MD cord-271653-4q2olzx1 14 12 benefit benefit VB cord-271653-4q2olzx1 14 13 from from IN cord-271653-4q2olzx1 14 14 the the DT cord-271653-4q2olzx1 14 15 advanced advanced JJ cord-271653-4q2olzx1 14 16 imaging imaging NN cord-271653-4q2olzx1 14 17 and and CC cord-271653-4q2olzx1 14 18 invasive invasive JJ cord-271653-4q2olzx1 14 19 procedures procedure NNS cord-271653-4q2olzx1 14 20 that that WDT cord-271653-4q2olzx1 14 21 present present VBP cord-271653-4q2olzx1 14 22 enormous enormous JJ cord-271653-4q2olzx1 14 23 logistical logistical JJ cord-271653-4q2olzx1 14 24 challenges challenge NNS cord-271653-4q2olzx1 14 25 in in IN cord-271653-4q2olzx1 14 26 the the DT cord-271653-4q2olzx1 14 27 current current JJ cord-271653-4q2olzx1 14 28 context context NN cord-271653-4q2olzx1 14 29 . . . cord-271653-4q2olzx1 15 1 Lacking lack VBG cord-271653-4q2olzx1 15 2 a a DT cord-271653-4q2olzx1 15 3 robust robust JJ cord-271653-4q2olzx1 15 4 evidence evidence NN cord-271653-4q2olzx1 15 5 base base NN cord-271653-4q2olzx1 15 6 , , , cord-271653-4q2olzx1 15 7 pathophysiologic pathophysiologic NN cord-271653-4q2olzx1 15 8 reasoning reasoning NN cord-271653-4q2olzx1 15 9 can can MD cord-271653-4q2olzx1 15 10 help help VB cord-271653-4q2olzx1 15 11 guide guide VB cord-271653-4q2olzx1 15 12 our -PRON- PRP$ cord-271653-4q2olzx1 15 13 choices choice NNS cord-271653-4q2olzx1 15 14 of of IN cord-271653-4q2olzx1 15 15 therapy therapy NN cord-271653-4q2olzx1 15 16 for for IN cord-271653-4q2olzx1 15 17 individual individual JJ cord-271653-4q2olzx1 15 18 clinical clinical JJ cord-271653-4q2olzx1 15 19 scenarios scenario NNS cord-271653-4q2olzx1 15 20 . . . cord-271653-4q2olzx1 16 1 We -PRON- PRP cord-271653-4q2olzx1 16 2 must must MD cord-271653-4q2olzx1 16 3 exercise exercise VB cord-271653-4q2olzx1 16 4 caution caution NN cord-271653-4q2olzx1 16 5 and and CC cord-271653-4q2olzx1 16 6 extreme extreme JJ cord-271653-4q2olzx1 16 7 humility humility NN cord-271653-4q2olzx1 16 8 , , , cord-271653-4q2olzx1 16 9 as as IN cord-271653-4q2olzx1 16 10 often often RB cord-271653-4q2olzx1 16 11 plausible plausible JJ cord-271653-4q2olzx1 16 12 interventions intervention NNS cord-271653-4q2olzx1 16 13 fail fail VBP cord-271653-4q2olzx1 16 14 when when WRB cord-271653-4q2olzx1 16 15 tested test VBN cord-271653-4q2olzx1 16 16 rigorously rigorously RB cord-271653-4q2olzx1 16 17 . . . cord-271653-4q2olzx1 17 1 But but CC cord-271653-4q2olzx1 17 2 act act VB cord-271653-4q2olzx1 17 3 today today NN cord-271653-4q2olzx1 17 4 we -PRON- PRP cord-271653-4q2olzx1 17 5 must must MD cord-271653-4q2olzx1 17 6 , , , cord-271653-4q2olzx1 17 7 and and CC cord-271653-4q2olzx1 17 8 understanding understand VBG cord-271653-4q2olzx1 17 9 the the DT cord-271653-4q2olzx1 17 10 multiplicity multiplicity NN cord-271653-4q2olzx1 17 11 of of IN cord-271653-4q2olzx1 17 12 mechanisms mechanism NNS cord-271653-4q2olzx1 17 13 of of IN cord-271653-4q2olzx1 17 14 myocardial myocardial JJ cord-271653-4q2olzx1 17 15 injury injury NN cord-271653-4q2olzx1 17 16 in in IN cord-271653-4q2olzx1 17 17 COVID-19 COVID-19 NNP cord-271653-4q2olzx1 17 18 infection infection NN cord-271653-4q2olzx1 17 19 will will MD cord-271653-4q2olzx1 17 20 help help VB cord-271653-4q2olzx1 17 21 us -PRON- PRP cord-271653-4q2olzx1 17 22 meet meet VB cord-271653-4q2olzx1 17 23 our -PRON- PRP$ cord-271653-4q2olzx1 17 24 mission mission NN cord-271653-4q2olzx1 17 25 unsupported unsupported JJ cord-271653-4q2olzx1 17 26 by by IN cord-271653-4q2olzx1 17 27 the the DT cord-271653-4q2olzx1 17 28 comfort comfort NN cord-271653-4q2olzx1 17 29 of of IN cord-271653-4q2olzx1 17 30 strong strong JJ cord-271653-4q2olzx1 17 31 data datum NNS cord-271653-4q2olzx1 17 32 . . . cord-271653-4q2olzx1 18 1 In in IN cord-271653-4q2olzx1 18 2 the the DT cord-271653-4q2olzx1 18 3 throes throe NNS cord-271653-4q2olzx1 18 4 of of IN cord-271653-4q2olzx1 18 5 the the DT cord-271653-4q2olzx1 18 6 current current JJ cord-271653-4q2olzx1 18 7 COVID-19 COVID-19 NNP cord-271653-4q2olzx1 18 8 pandemic pandemic NN cord-271653-4q2olzx1 18 9 , , , cord-271653-4q2olzx1 18 10 interest interest NN cord-271653-4q2olzx1 18 11 has have VBZ cord-271653-4q2olzx1 18 12 burgeoned burgeon VBN cord-271653-4q2olzx1 18 13 in in IN cord-271653-4q2olzx1 18 14 the the DT cord-271653-4q2olzx1 18 15 cardiovascular cardiovascular JJ cord-271653-4q2olzx1 18 16 complications complication NNS cord-271653-4q2olzx1 18 17 of of IN cord-271653-4q2olzx1 18 18 this this DT cord-271653-4q2olzx1 18 19 virulent virulent JJ cord-271653-4q2olzx1 18 20 viral viral JJ cord-271653-4q2olzx1 18 21 infection infection NN cord-271653-4q2olzx1 18 22 . . . cord-271653-4q2olzx1 19 1 As as IN cord-271653-4q2olzx1 19 2 troponin troponin JJ cord-271653-4q2olzx1 19 3 , , , cord-271653-4q2olzx1 19 4 a a DT cord-271653-4q2olzx1 19 5 biomarker biomarker NN cord-271653-4q2olzx1 19 6 of of IN cord-271653-4q2olzx1 19 7 cardiac cardiac JJ cord-271653-4q2olzx1 19 8 injury injury NN cord-271653-4q2olzx1 19 9 , , , cord-271653-4q2olzx1 19 10 often often RB cord-271653-4q2olzx1 19 11 rises rise VBZ cord-271653-4q2olzx1 19 12 in in IN cord-271653-4q2olzx1 19 13 hospitalized hospitalize VBN cord-271653-4q2olzx1 19 14 patients patient NNS cord-271653-4q2olzx1 19 15 , , , cord-271653-4q2olzx1 19 16 its -PRON- PRP$ cord-271653-4q2olzx1 19 17 interpretation interpretation NN cord-271653-4q2olzx1 19 18 and and CC cord-271653-4q2olzx1 19 19 actionability actionability NN cord-271653-4q2olzx1 19 20 require require VBP cord-271653-4q2olzx1 19 21 careful careful JJ cord-271653-4q2olzx1 19 22 consideration consideration NN cord-271653-4q2olzx1 19 23 . . . cord-271653-4q2olzx1 20 1 Fulminant Fulminant NNP cord-271653-4q2olzx1 20 2 myocarditis myocarditis NN cord-271653-4q2olzx1 20 3 due due IN cord-271653-4q2olzx1 20 4 to to IN cord-271653-4q2olzx1 20 5 direct direct JJ cord-271653-4q2olzx1 20 6 viral viral JJ cord-271653-4q2olzx1 20 7 infection infection NN cord-271653-4q2olzx1 20 8 can can MD cord-271653-4q2olzx1 20 9 certainly certainly RB cord-271653-4q2olzx1 20 10 occur occur VB cord-271653-4q2olzx1 20 11 , , , cord-271653-4q2olzx1 20 12 but but CC cord-271653-4q2olzx1 20 13 patients patient NNS cord-271653-4q2olzx1 20 14 with with IN cord-271653-4q2olzx1 20 15 increased increase VBN cord-271653-4q2olzx1 20 16 oxygen oxygen NN cord-271653-4q2olzx1 20 17 demands demand NNS cord-271653-4q2olzx1 20 18 due due JJ cord-271653-4q2olzx1 20 19 to to IN cord-271653-4q2olzx1 20 20 tachycardia tachycardia NN cord-271653-4q2olzx1 20 21 and and CC cord-271653-4q2olzx1 20 22 fever fever NN cord-271653-4q2olzx1 20 23 , , , cord-271653-4q2olzx1 20 24 and and CC cord-271653-4q2olzx1 20 25 reduced reduce VBN cord-271653-4q2olzx1 20 26 oxygen oxygen NN cord-271653-4q2olzx1 20 27 delivery delivery NN cord-271653-4q2olzx1 20 28 due due JJ cord-271653-4q2olzx1 20 29 to to IN cord-271653-4q2olzx1 20 30 hypotension hypotension NN cord-271653-4q2olzx1 20 31 and and CC cord-271653-4q2olzx1 20 32 hypoxemia hypoxemia NN cord-271653-4q2olzx1 20 33 can can MD cord-271653-4q2olzx1 20 34 cause cause VB cord-271653-4q2olzx1 20 35 myocardial myocardial JJ cord-271653-4q2olzx1 20 36 injury injury NN cord-271653-4q2olzx1 20 37 indirectly indirectly RB cord-271653-4q2olzx1 20 38 . . . cord-271653-4q2olzx1 21 1 Cytokines cytokine NNS cord-271653-4q2olzx1 21 2 released release VBN cord-271653-4q2olzx1 21 3 during during IN cord-271653-4q2olzx1 21 4 the the DT cord-271653-4q2olzx1 21 5 acute acute JJ cord-271653-4q2olzx1 21 6 infection infection NN cord-271653-4q2olzx1 21 7 can can MD cord-271653-4q2olzx1 21 8 elicit elicit VB cord-271653-4q2olzx1 21 9 activation activation NN cord-271653-4q2olzx1 21 10 of of IN cord-271653-4q2olzx1 21 11 cells cell NNS cord-271653-4q2olzx1 21 12 within within IN cord-271653-4q2olzx1 21 13 pre pre JJ cord-271653-4q2olzx1 21 14 - - JJ cord-271653-4q2olzx1 21 15 existing existing JJ cord-271653-4q2olzx1 21 16 atherosclerotic atherosclerotic JJ cord-271653-4q2olzx1 21 17 lesions lesion NNS cord-271653-4q2olzx1 21 18 , , , cord-271653-4q2olzx1 21 19 augmenting augment VBG cord-271653-4q2olzx1 21 20 thrombotic thrombotic JJ cord-271653-4q2olzx1 21 21 risk risk NN cord-271653-4q2olzx1 21 22 and and CC cord-271653-4q2olzx1 21 23 risk risk NN cord-271653-4q2olzx1 21 24 of of IN cord-271653-4q2olzx1 21 25 ischemic ischemic JJ cord-271653-4q2olzx1 21 26 syndromes syndrome NNS cord-271653-4q2olzx1 21 27 . . . cord-271653-4q2olzx1 22 1 Moreover moreover RB cord-271653-4q2olzx1 22 2 , , , cord-271653-4q2olzx1 22 3 microvascular microvascular JJ cord-271653-4q2olzx1 22 4 activation activation NN cord-271653-4q2olzx1 22 5 by by IN cord-271653-4q2olzx1 22 6 cytokines cytokine NNS cord-271653-4q2olzx1 22 7 can can MD cord-271653-4q2olzx1 22 8 cause cause VB cord-271653-4q2olzx1 22 9 not not RB cord-271653-4q2olzx1 22 10 only only RB cord-271653-4q2olzx1 22 11 myocardial myocardial JJ cord-271653-4q2olzx1 22 12 injury injury NN cord-271653-4q2olzx1 22 13 but but CC cord-271653-4q2olzx1 22 14 harm harm NN cord-271653-4q2olzx1 22 15 other other JJ cord-271653-4q2olzx1 22 16 organ organ NN cord-271653-4q2olzx1 22 17 systems system NNS cord-271653-4q2olzx1 22 18 commonly commonly RB cord-271653-4q2olzx1 22 19 involved involve VBN cord-271653-4q2olzx1 22 20 in in IN cord-271653-4q2olzx1 22 21 COVID-19 covid-19 JJ cord-271653-4q2olzx1 22 22 infections infection NNS cord-271653-4q2olzx1 22 23 including include VBG cord-271653-4q2olzx1 22 24 the the DT cord-271653-4q2olzx1 22 25 kidneys kidney NNS cord-271653-4q2olzx1 22 26 . . . cord-271653-4q2olzx1 23 1 Dealing deal VBG cord-271653-4q2olzx1 23 2 with with IN cord-271653-4q2olzx1 23 3 the the DT cord-271653-4q2olzx1 23 4 immense immense JJ cord-271653-4q2olzx1 23 5 challenge challenge NN cord-271653-4q2olzx1 23 6 of of IN cord-271653-4q2olzx1 23 7 COVID-19 COVID-19 NNP cord-271653-4q2olzx1 23 8 disease disease NN cord-271653-4q2olzx1 23 9 , , , cord-271653-4q2olzx1 23 10 confronted confront VBN cord-271653-4q2olzx1 23 11 with with IN cord-271653-4q2olzx1 23 12 severely severely RB cord-271653-4q2olzx1 23 13 ill ill JJ cord-271653-4q2olzx1 23 14 patients patient NNS cord-271653-4q2olzx1 23 15 in in IN cord-271653-4q2olzx1 23 16 dire dire JJ cord-271653-4q2olzx1 23 17 straits strait NNS cord-271653-4q2olzx1 23 18 with with IN cord-271653-4q2olzx1 23 19 virtually virtually RB cord-271653-4q2olzx1 23 20 no no DT cord-271653-4q2olzx1 23 21 rigorous rigorous JJ cord-271653-4q2olzx1 23 22 evidence evidence NN cord-271653-4q2olzx1 23 23 base base NN cord-271653-4q2olzx1 23 24 to to TO cord-271653-4q2olzx1 23 25 guide guide VB cord-271653-4q2olzx1 23 26 our -PRON- PRP$ cord-271653-4q2olzx1 23 27 therapy therapy NN cord-271653-4q2olzx1 23 28 , , , cord-271653-4q2olzx1 23 29 we -PRON- PRP cord-271653-4q2olzx1 23 30 must must MD cord-271653-4q2olzx1 23 31 call call VB cord-271653-4q2olzx1 23 32 upon upon IN cord-271653-4q2olzx1 23 33 our -PRON- PRP$ cord-271653-4q2olzx1 23 34 clinical clinical JJ cord-271653-4q2olzx1 23 35 skills skill NNS cord-271653-4q2olzx1 23 36 and and CC cord-271653-4q2olzx1 23 37 judgment judgment NN cord-271653-4q2olzx1 23 38 . . . cord-271653-4q2olzx1 24 1 These these DT cord-271653-4q2olzx1 24 2 touchstones touchstone NNS cord-271653-4q2olzx1 24 3 can can MD cord-271653-4q2olzx1 24 4 help help VB cord-271653-4q2olzx1 24 5 guide guide VB cord-271653-4q2olzx1 24 6 us -PRON- PRP cord-271653-4q2olzx1 24 7 in in IN cord-271653-4q2olzx1 24 8 selecting select VBG cord-271653-4q2olzx1 24 9 patients patient NNS cord-271653-4q2olzx1 24 10 who who WP cord-271653-4q2olzx1 24 11 might may MD cord-271653-4q2olzx1 24 12 benefit benefit VB cord-271653-4q2olzx1 24 13 from from IN cord-271653-4q2olzx1 24 14 the the DT cord-271653-4q2olzx1 24 15 advanced advanced JJ cord-271653-4q2olzx1 24 16 imaging imaging NN cord-271653-4q2olzx1 24 17 and and CC cord-271653-4q2olzx1 24 18 invasive invasive JJ cord-271653-4q2olzx1 24 19 procedures procedure NNS cord-271653-4q2olzx1 24 20 that that WDT cord-271653-4q2olzx1 24 21 present present VBP cord-271653-4q2olzx1 24 22 enormous enormous JJ cord-271653-4q2olzx1 24 23 logistical logistical JJ cord-271653-4q2olzx1 24 24 challenges challenge NNS cord-271653-4q2olzx1 24 25 in in IN cord-271653-4q2olzx1 24 26 the the DT cord-271653-4q2olzx1 24 27 current current JJ cord-271653-4q2olzx1 24 28 context context NN cord-271653-4q2olzx1 24 29 . . . cord-271653-4q2olzx1 25 1 Lacking lack VBG cord-271653-4q2olzx1 25 2 a a DT cord-271653-4q2olzx1 25 3 robust robust JJ cord-271653-4q2olzx1 25 4 evidence evidence NN cord-271653-4q2olzx1 25 5 base base NN cord-271653-4q2olzx1 25 6 , , , cord-271653-4q2olzx1 25 7 pathophysiologic pathophysiologic NN cord-271653-4q2olzx1 25 8 reasoning reasoning NN cord-271653-4q2olzx1 25 9 can can MD cord-271653-4q2olzx1 25 10 help help VB cord-271653-4q2olzx1 25 11 guide guide VB cord-271653-4q2olzx1 25 12 our -PRON- PRP$ cord-271653-4q2olzx1 25 13 choices choice NNS cord-271653-4q2olzx1 25 14 of of IN cord-271653-4q2olzx1 25 15 therapy therapy NN cord-271653-4q2olzx1 25 16 for for IN cord-271653-4q2olzx1 25 17 individual individual JJ cord-271653-4q2olzx1 25 18 clinical clinical JJ cord-271653-4q2olzx1 25 19 scenarios scenario NNS cord-271653-4q2olzx1 25 20 . . . cord-271653-4q2olzx1 26 1 We -PRON- PRP cord-271653-4q2olzx1 26 2 must must MD cord-271653-4q2olzx1 26 3 exercise exercise VB cord-271653-4q2olzx1 26 4 caution caution NN cord-271653-4q2olzx1 26 5 and and CC cord-271653-4q2olzx1 26 6 extreme extreme JJ cord-271653-4q2olzx1 26 7 humility humility NN cord-271653-4q2olzx1 26 8 , , , cord-271653-4q2olzx1 26 9 as as IN cord-271653-4q2olzx1 26 10 often often RB cord-271653-4q2olzx1 26 11 plausible plausible JJ cord-271653-4q2olzx1 26 12 interventions intervention NNS cord-271653-4q2olzx1 26 13 fail fail VBP cord-271653-4q2olzx1 26 14 when when WRB cord-271653-4q2olzx1 26 15 tested test VBN cord-271653-4q2olzx1 26 16 rigorously rigorously RB cord-271653-4q2olzx1 26 17 . . . cord-271653-4q2olzx1 27 1 But but CC cord-271653-4q2olzx1 27 2 act act VB cord-271653-4q2olzx1 27 3 today today NN cord-271653-4q2olzx1 27 4 we -PRON- PRP cord-271653-4q2olzx1 27 5 must must MD cord-271653-4q2olzx1 27 6 , , , cord-271653-4q2olzx1 27 7 and and CC cord-271653-4q2olzx1 27 8 understanding understand VBG cord-271653-4q2olzx1 27 9 the the DT cord-271653-4q2olzx1 27 10 multiplicity multiplicity NN cord-271653-4q2olzx1 27 11 of of IN cord-271653-4q2olzx1 27 12 mechanisms mechanism NNS cord-271653-4q2olzx1 27 13 of of IN cord-271653-4q2olzx1 27 14 myocardial myocardial JJ cord-271653-4q2olzx1 27 15 injury injury NN cord-271653-4q2olzx1 27 16 in in IN cord-271653-4q2olzx1 27 17 COVID-19 COVID-19 NNP cord-271653-4q2olzx1 27 18 infection infection NN cord-271653-4q2olzx1 27 19 will will MD cord-271653-4q2olzx1 27 20 help help VB cord-271653-4q2olzx1 27 21 us -PRON- PRP cord-271653-4q2olzx1 27 22 meet meet VB cord-271653-4q2olzx1 27 23 our -PRON- PRP$ cord-271653-4q2olzx1 27 24 mission mission NN cord-271653-4q2olzx1 27 25 unsupported unsupported JJ cord-271653-4q2olzx1 27 26 by by IN cord-271653-4q2olzx1 27 27 the the DT cord-271653-4q2olzx1 27 28 comfort comfort NN cord-271653-4q2olzx1 27 29 of of IN cord-271653-4q2olzx1 27 30 strong strong JJ cord-271653-4q2olzx1 27 31 data datum NNS cord-271653-4q2olzx1 27 32 . . . cord-271653-4q2olzx1 28 1 In in IN cord-271653-4q2olzx1 28 2 the the DT cord-271653-4q2olzx1 28 3 throes throe NNS cord-271653-4q2olzx1 28 4 of of IN cord-271653-4q2olzx1 28 5 the the DT cord-271653-4q2olzx1 28 6 current current JJ cord-271653-4q2olzx1 28 7 pandemic pandemic NN cord-271653-4q2olzx1 28 8 , , , cord-271653-4q2olzx1 28 9 intense intense JJ cord-271653-4q2olzx1 28 10 interest interest NN cord-271653-4q2olzx1 28 11 has have VBZ cord-271653-4q2olzx1 28 12 burgeoned burgeon VBN cord-271653-4q2olzx1 28 13 in in IN cord-271653-4q2olzx1 28 14 cardiovascular cardiovascular JJ cord-271653-4q2olzx1 28 15 involvement involvement NN cord-271653-4q2olzx1 28 16 by by IN cord-271653-4q2olzx1 28 17 the the DT cord-271653-4q2olzx1 28 18 novel novel JJ cord-271653-4q2olzx1 28 19 coronavirus coronavirus NN cord-271653-4q2olzx1 28 20 known know VBN cord-271653-4q2olzx1 28 21 as as IN cord-271653-4q2olzx1 28 22 COVID-19 COVID-19 NNP cord-271653-4q2olzx1 28 23 . . . cord-271653-4q2olzx1 29 1 Cardiologists cardiologist NNS cord-271653-4q2olzx1 29 2 as as RB cord-271653-4q2olzx1 29 3 well well RB cord-271653-4q2olzx1 29 4 as as IN cord-271653-4q2olzx1 29 5 other other JJ cord-271653-4q2olzx1 29 6 practitioners practitioner NNS cord-271653-4q2olzx1 29 7 who who WP cord-271653-4q2olzx1 29 8 care care VBP cord-271653-4q2olzx1 29 9 for for IN cord-271653-4q2olzx1 29 10 those those DT cord-271653-4q2olzx1 29 11 with with IN cord-271653-4q2olzx1 29 12 this this DT cord-271653-4q2olzx1 29 13 virulent virulent JJ cord-271653-4q2olzx1 29 14 viral viral JJ cord-271653-4q2olzx1 29 15 infection infection NN cord-271653-4q2olzx1 29 16 , , , cord-271653-4q2olzx1 29 17 and and CC cord-271653-4q2olzx1 29 18 indeed indeed RB cord-271653-4q2olzx1 29 19 the the DT cord-271653-4q2olzx1 29 20 general general JJ cord-271653-4q2olzx1 29 21 public public NN cord-271653-4q2olzx1 29 22 as as IN cord-271653-4q2olzx1 29 23 To to TO cord-271653-4q2olzx1 29 24 approach approach VB cord-271653-4q2olzx1 29 25 this this DT cord-271653-4q2olzx1 29 26 question question NN cord-271653-4q2olzx1 30 1 , , , cord-271653-4q2olzx1 30 2 we -PRON- PRP cord-271653-4q2olzx1 30 3 need need VBP cord-271653-4q2olzx1 30 4 to to TO cord-271653-4q2olzx1 30 5 distinguish distinguish VB cord-271653-4q2olzx1 30 6 myocarditis myocarditis NN cord-271653-4q2olzx1 30 7 due due IN cord-271653-4q2olzx1 30 8 to to IN cord-271653-4q2olzx1 30 9 infection infection NN cord-271653-4q2olzx1 30 10 of of IN cord-271653-4q2olzx1 30 11 cardiac cardiac JJ cord-271653-4q2olzx1 30 12 cells cell NNS cord-271653-4q2olzx1 30 13 from from IN cord-271653-4q2olzx1 30 14 myocardial myocardial JJ cord-271653-4q2olzx1 30 15 ischemic ischemic JJ cord-271653-4q2olzx1 30 16 injury injury NN cord-271653-4q2olzx1 30 17 . . . cord-271653-4q2olzx1 31 1 Flow flow VB cord-271653-4q2olzx1 31 2 embarrassment embarrassment NN cord-271653-4q2olzx1 31 3 to to IN cord-271653-4q2olzx1 31 4 the the DT cord-271653-4q2olzx1 31 5 heart heart NN cord-271653-4q2olzx1 31 6 muscle muscle NN cord-271653-4q2olzx1 31 7 can can MD cord-271653-4q2olzx1 31 8 result result VB cord-271653-4q2olzx1 31 9 from from IN cord-271653-4q2olzx1 31 10 lesions lesion NNS cord-271653-4q2olzx1 31 11 in in IN cord-271653-4q2olzx1 31 12 epicardial epicardial JJ cord-271653-4q2olzx1 31 13 coronary coronary JJ cord-271653-4q2olzx1 31 14 arteries artery NNS cord-271653-4q2olzx1 31 15 or or CC cord-271653-4q2olzx1 31 16 in in IN cord-271653-4q2olzx1 31 17 the the DT cord-271653-4q2olzx1 31 18 heart heart NN cord-271653-4q2olzx1 31 19 's 's POS cord-271653-4q2olzx1 31 20 microvasculature microvasculature NN cord-271653-4q2olzx1 31 21 . . . cord-271653-4q2olzx1 32 1 Cardiac cardiac JJ cord-271653-4q2olzx1 32 2 ischemia ischemia NN cord-271653-4q2olzx1 32 3 can can MD cord-271653-4q2olzx1 32 4 also also RB cord-271653-4q2olzx1 32 5 arise arise VB cord-271653-4q2olzx1 32 6 from from IN cord-271653-4q2olzx1 32 7 an an DT cord-271653-4q2olzx1 32 8 imbalance imbalance NN cord-271653-4q2olzx1 32 9 between between IN cord-271653-4q2olzx1 32 10 oxygen oxygen NN cord-271653-4q2olzx1 32 11 supply supply NN cord-271653-4q2olzx1 32 12 and and CC cord-271653-4q2olzx1 32 13 demand demand NN cord-271653-4q2olzx1 32 14 , , , cord-271653-4q2olzx1 32 15 a a DT cord-271653-4q2olzx1 32 16 type type NN cord-271653-4q2olzx1 32 17 2 2 CD cord-271653-4q2olzx1 32 18 acute acute JJ cord-271653-4q2olzx1 32 19 coronary coronary JJ cord-271653-4q2olzx1 32 20 syndrome syndrome NN cord-271653-4q2olzx1 32 21 , , , cord-271653-4q2olzx1 32 22 a a DT cord-271653-4q2olzx1 32 23 situation situation NN cord-271653-4q2olzx1 32 24 that that WDT cord-271653-4q2olzx1 32 25 can can MD cord-271653-4q2olzx1 32 26 prevail prevail VB cord-271653-4q2olzx1 32 27 in in IN cord-271653-4q2olzx1 32 28 acute acute JJ cord-271653-4q2olzx1 32 29 infections infection NNS cord-271653-4q2olzx1 32 30 , , , cord-271653-4q2olzx1 32 31 particularly particularly RB cord-271653-4q2olzx1 32 32 those those DT cord-271653-4q2olzx1 32 33 that that WDT cord-271653-4q2olzx1 32 34 affect affect VBP cord-271653-4q2olzx1 32 35 the the DT cord-271653-4q2olzx1 32 36 lungs lung NNS cord-271653-4q2olzx1 32 37 like like IN cord-271653-4q2olzx1 32 38 COVID19 COVID19 NNP cord-271653-4q2olzx1 32 39 . . . cord-271653-4q2olzx1 33 1 Several several JJ cord-271653-4q2olzx1 33 2 of of IN cord-271653-4q2olzx1 33 3 these these DT cord-271653-4q2olzx1 33 4 pathophysiologic pathophysiologic JJ cord-271653-4q2olzx1 33 5 pathways pathway NNS cord-271653-4q2olzx1 33 6 to to IN cord-271653-4q2olzx1 33 7 myocardial myocardial JJ cord-271653-4q2olzx1 33 8 ischemia ischemia NN cord-271653-4q2olzx1 33 9 may may MD cord-271653-4q2olzx1 33 10 affect affect VB cord-271653-4q2olzx1 33 11 those those DT cord-271653-4q2olzx1 33 12 without without IN cord-271653-4q2olzx1 33 13 substantial substantial JJ cord-271653-4q2olzx1 33 14 or or CC cord-271653-4q2olzx1 33 15 obstructive obstructive JJ cord-271653-4q2olzx1 33 16 coronary coronary JJ cord-271653-4q2olzx1 33 17 artery artery NN cord-271653-4q2olzx1 33 18 atherosclerosis atherosclerosis NN cord-271653-4q2olzx1 33 19 . . . cord-271653-4q2olzx1 34 1 Hence hence RB cord-271653-4q2olzx1 34 2 , , , cord-271653-4q2olzx1 34 3 the the DT cord-271653-4q2olzx1 34 4 distinction distinction NN cord-271653-4q2olzx1 34 5 between between IN cord-271653-4q2olzx1 34 6 these these DT cord-271653-4q2olzx1 34 7 various various JJ cord-271653-4q2olzx1 34 8 mechanisms mechanism NNS cord-271653-4q2olzx1 34 9 has have VBZ cord-271653-4q2olzx1 34 10 important important JJ cord-271653-4q2olzx1 34 11 clinical clinical JJ cord-271653-4q2olzx1 34 12 consequences consequence NNS cord-271653-4q2olzx1 34 13 . . . cord-271653-4q2olzx1 35 1 The the DT cord-271653-4q2olzx1 35 2 need need NN cord-271653-4q2olzx1 35 3 for for IN cord-271653-4q2olzx1 35 4 arduous arduous JJ cord-271653-4q2olzx1 35 5 imaging imaging NN cord-271653-4q2olzx1 35 6 studies study NNS cord-271653-4q2olzx1 35 7 and and CC cord-271653-4q2olzx1 35 8 invasive invasive JJ cord-271653-4q2olzx1 35 9 evaluation evaluation NN cord-271653-4q2olzx1 35 10 may may MD cord-271653-4q2olzx1 35 11 vary vary VB cord-271653-4q2olzx1 35 12 considerably considerably RB cord-271653-4q2olzx1 35 13 in in IN cord-271653-4q2olzx1 35 14 these these DT cord-271653-4q2olzx1 35 15 different different JJ cord-271653-4q2olzx1 35 16 scenarios scenario NNS cord-271653-4q2olzx1 35 17 , , , cord-271653-4q2olzx1 35 18 an an DT cord-271653-4q2olzx1 35 19 issue issue NN cord-271653-4q2olzx1 35 20 of of IN cord-271653-4q2olzx1 35 21 great great JJ cord-271653-4q2olzx1 35 22 import import NN cord-271653-4q2olzx1 35 23 in in IN cord-271653-4q2olzx1 35 24 acute acute JJ cord-271653-4q2olzx1 35 25 care care NN cord-271653-4q2olzx1 35 26 facilities facility NNS cord-271653-4q2olzx1 35 27 stretched stretch VBD cord-271653-4q2olzx1 35 28 to to IN cord-271653-4q2olzx1 35 29 or or CC cord-271653-4q2olzx1 35 30 beyond beyond IN cord-271653-4q2olzx1 35 31 their -PRON- PRP$ cord-271653-4q2olzx1 35 32 limits limit NNS cord-271653-4q2olzx1 35 33 during during IN cord-271653-4q2olzx1 35 34 a a DT cord-271653-4q2olzx1 35 35 pandemic pandemic NN cord-271653-4q2olzx1 35 36 with with IN cord-271653-4q2olzx1 35 37 a a DT cord-271653-4q2olzx1 35 38 readily readily RB cord-271653-4q2olzx1 35 39 contagious contagious JJ cord-271653-4q2olzx1 35 40 and and CC cord-271653-4q2olzx1 35 41 virulent virulent JJ cord-271653-4q2olzx1 35 42 infectious infectious JJ cord-271653-4q2olzx1 35 43 agent agent NN cord-271653-4q2olzx1 35 44 such such JJ cord-271653-4q2olzx1 35 45 as as IN cord-271653-4q2olzx1 35 46 COVID19 COVID19 NNP cord-271653-4q2olzx1 35 47 . . . cord-271653-4q2olzx1 36 1 Considering consider VBG cord-271653-4q2olzx1 36 2 the the DT cord-271653-4q2olzx1 36 3 pathophysiologic pathophysiologic JJ cord-271653-4q2olzx1 36 4 paths path NNS cord-271653-4q2olzx1 36 5 to to IN cord-271653-4q2olzx1 36 6 cardiac cardiac JJ cord-271653-4q2olzx1 36 7 injury injury NN cord-271653-4q2olzx1 36 8 can can MD cord-271653-4q2olzx1 36 9 inform inform VB cord-271653-4q2olzx1 36 10 judgement judgement NN cord-271653-4q2olzx1 36 11 regarding regard VBG cord-271653-4q2olzx1 36 12 the the DT cord-271653-4q2olzx1 36 13 necessity necessity NN cord-271653-4q2olzx1 36 14 of of IN cord-271653-4q2olzx1 36 15 transport transport NN cord-271653-4q2olzx1 36 16 of of IN cord-271653-4q2olzx1 36 17 severely severely RB cord-271653-4q2olzx1 36 18 ill ill JJ cord-271653-4q2olzx1 36 19 patients patient NNS cord-271653-4q2olzx1 36 20 and and CC cord-271653-4q2olzx1 36 21 the the DT cord-271653-4q2olzx1 36 22 performance performance NN cord-271653-4q2olzx1 36 23 invasive invasive JJ cord-271653-4q2olzx1 36 24 procedures procedure NNS cord-271653-4q2olzx1 36 25 . . . cord-271653-4q2olzx1 36 26 _SP cord-271653-4q2olzx1 37 1 The the DT cord-271653-4q2olzx1 37 2 demographic demographic JJ cord-271653-4q2olzx1 37 3 most most RBS cord-271653-4q2olzx1 37 4 often often RB cord-271653-4q2olzx1 37 5 affected affect VBN cord-271653-4q2olzx1 37 6 by by IN cord-271653-4q2olzx1 37 7 life life NN cord-271653-4q2olzx1 37 8 - - HYPH cord-271653-4q2olzx1 37 9 threatening threaten VBG cord-271653-4q2olzx1 37 10 and and CC cord-271653-4q2olzx1 37 11 fatal fatal JJ cord-271653-4q2olzx1 37 12 COVID-19 covid-19 NN cord-271653-4q2olzx1 37 13 has have VBZ cord-271653-4q2olzx1 37 14 a a DT cord-271653-4q2olzx1 37 15 high high JJ cord-271653-4q2olzx1 37 16 prior prior JJ cord-271653-4q2olzx1 37 17 probability probability NN cord-271653-4q2olzx1 37 18 of of IN cord-271653-4q2olzx1 37 19 pre pre JJ cord-271653-4q2olzx1 37 20 - - JJ cord-271653-4q2olzx1 37 21 existing existing JJ cord-271653-4q2olzx1 37 22 atherosclerotic atherosclerotic JJ cord-271653-4q2olzx1 37 23 lesions lesion NNS cord-271653-4q2olzx1 37 24 : : : cord-271653-4q2olzx1 37 25 the the DT cord-271653-4q2olzx1 37 26 elderly elderly JJ cord-271653-4q2olzx1 37 27 , , , cord-271653-4q2olzx1 37 28 evident evident JJ cord-271653-4q2olzx1 37 29 male male JJ cord-271653-4q2olzx1 37 30 predominance predominance NN cord-271653-4q2olzx1 37 31 , , , cord-271653-4q2olzx1 37 32 and and CC cord-271653-4q2olzx1 37 33 those those DT cord-271653-4q2olzx1 37 34 with with IN cord-271653-4q2olzx1 37 35 pre pre JJ cord-271653-4q2olzx1 37 36 - - JJ cord-271653-4q2olzx1 37 37 existing existing JJ cord-271653-4q2olzx1 37 38 lung lung NN cord-271653-4q2olzx1 37 39 disease disease NN cord-271653-4q2olzx1 37 40 including include VBG cord-271653-4q2olzx1 37 41 that that IN cord-271653-4q2olzx1 37 42 associated associate VBN cord-271653-4q2olzx1 37 43 with with IN cord-271653-4q2olzx1 37 44 cigarette cigarette NN cord-271653-4q2olzx1 37 45 smoking smoking NN cord-271653-4q2olzx1 37 46 , , , cord-271653-4q2olzx1 37 47 a a DT cord-271653-4q2olzx1 37 48 risk risk NN cord-271653-4q2olzx1 37 49 factor factor NN cord-271653-4q2olzx1 37 50 for for IN cord-271653-4q2olzx1 37 51 atherosclerosis atherosclerosis NN cord-271653-4q2olzx1 37 52 . . . cord-271653-4q2olzx1 38 1 Remote remote JJ cord-271653-4q2olzx1 38 2 infections infection NNS cord-271653-4q2olzx1 38 3 such such JJ cord-271653-4q2olzx1 38 4 as as IN cord-271653-4q2olzx1 38 5 the the DT cord-271653-4q2olzx1 38 6 severe severe JJ cord-271653-4q2olzx1 38 7 pneumonitis pneumonitis NN cord-271653-4q2olzx1 38 8 that that IN cord-271653-4q2olzx1 38 9 too too RB cord-271653-4q2olzx1 38 10 commonly commonly RB cord-271653-4q2olzx1 38 11 complicates complicate VBZ cord-271653-4q2olzx1 38 12 COVID-19 COVID-19 NNP cord-271653-4q2olzx1 38 13 can can MD cord-271653-4q2olzx1 38 14 elicit elicit VB cord-271653-4q2olzx1 38 15 an an DT cord-271653-4q2olzx1 38 16 acute acute JJ cord-271653-4q2olzx1 38 17 exacerbation exacerbation NN cord-271653-4q2olzx1 38 18 of of IN cord-271653-4q2olzx1 38 19 the the DT cord-271653-4q2olzx1 38 20 chronic chronic JJ cord-271653-4q2olzx1 38 21 smoldering smolder VBG cord-271653-4q2olzx1 38 22 inflammation inflammation NN cord-271653-4q2olzx1 38 23 that that WDT cord-271653-4q2olzx1 38 24 characterizes characterize VBZ cord-271653-4q2olzx1 38 25 coronary coronary JJ cord-271653-4q2olzx1 38 26 atherosclerotic atherosclerotic JJ cord-271653-4q2olzx1 38 27 lesions lesion NNS cord-271653-4q2olzx1 38 28 ( ( -LRB- cord-271653-4q2olzx1 38 29 Figure figure NN cord-271653-4q2olzx1 38 30 2 2 CD cord-271653-4q2olzx1 38 31 ) ) -RRB- cord-271653-4q2olzx1 38 32 . . . cord-271653-4q2olzx1 39 1 The the DT cord-271653-4q2olzx1 39 2 inflammatory inflammatory JJ cord-271653-4q2olzx1 39 3 cells cell NNS cord-271653-4q2olzx1 39 4 at at IN cord-271653-4q2olzx1 39 5 a a DT cord-271653-4q2olzx1 39 6 site site NN cord-271653-4q2olzx1 39 7 of of IN cord-271653-4q2olzx1 39 8 regional regional JJ cord-271653-4q2olzx1 39 9 infection infection NN cord-271653-4q2olzx1 39 10 such such JJ cord-271653-4q2olzx1 39 11 as as IN cord-271653-4q2olzx1 39 12 the the DT cord-271653-4q2olzx1 39 13 lungs lung NNS cord-271653-4q2olzx1 39 14 in in IN cord-271653-4q2olzx1 39 15 COVID19 COVID19 NNP cord-271653-4q2olzx1 39 16 pneumonitis pneumonitis NN cord-271653-4q2olzx1 39 17 can can MD cord-271653-4q2olzx1 39 18 produce produce VB cord-271653-4q2olzx1 39 19 cytokines cytokine NNS cord-271653-4q2olzx1 39 20 such such JJ cord-271653-4q2olzx1 39 21 as as IN cord-271653-4q2olzx1 39 22 interleukins interleukin NNS cord-271653-4q2olzx1 39 23 ( ( -LRB- cord-271653-4q2olzx1 39 24 IL)-1 il)-1 JJ cord-271653-4q2olzx1 39 25 and and CC cord-271653-4q2olzx1 39 26 -6 -6 NNP cord-271653-4q2olzx1 39 27 , , , cord-271653-4q2olzx1 39 28 and and CC cord-271653-4q2olzx1 39 29 tumor tumor NN cord-271653-4q2olzx1 39 30 necrosis necrosis NN cord-271653-4q2olzx1 39 31 factor factor NN cord-271653-4q2olzx1 39 32 , , , cord-271653-4q2olzx1 39 33 mediators mediator NNS cord-271653-4q2olzx1 39 34 that that IN cord-271653-4q2olzx1 39 35 not not RB cord-271653-4q2olzx1 39 36 only only RB cord-271653-4q2olzx1 39 37 propagate propagate VBP cord-271653-4q2olzx1 39 38 local local JJ cord-271653-4q2olzx1 39 39 inflammation inflammation NN cord-271653-4q2olzx1 39 40 but but CC cord-271653-4q2olzx1 39 41 can can MD cord-271653-4q2olzx1 39 42 enter enter VB cord-271653-4q2olzx1 39 43 the the DT cord-271653-4q2olzx1 39 44 systemic systemic JJ cord-271653-4q2olzx1 39 45 circulation circulation NN cord-271653-4q2olzx1 39 46 . . . cord-271653-4q2olzx1 40 1 Such such JJ cord-271653-4q2olzx1 40 2 circulating circulate VBG cord-271653-4q2olzx1 40 3 cytokines cytokine NNS cord-271653-4q2olzx1 40 4 can can MD cord-271653-4q2olzx1 40 5 stimulate stimulate VB cord-271653-4q2olzx1 40 6 macrophages macrophage NNS cord-271653-4q2olzx1 40 7 within within IN cord-271653-4q2olzx1 40 8 the the DT cord-271653-4q2olzx1 40 9 plaque plaque NN cord-271653-4q2olzx1 40 10 to to TO cord-271653-4q2olzx1 40 11 augment augment VB cord-271653-4q2olzx1 40 12 local local JJ cord-271653-4q2olzx1 40 13 cytokine cytokine NN cord-271653-4q2olzx1 40 14 production production NN cord-271653-4q2olzx1 40 15 and and CC cord-271653-4q2olzx1 40 16 provoke provoke VB cord-271653-4q2olzx1 40 17 an an DT cord-271653-4q2olzx1 40 18 increase increase NN cord-271653-4q2olzx1 40 19 in in IN cord-271653-4q2olzx1 40 20 tissue tissue NN cord-271653-4q2olzx1 40 21 factor factor NN cord-271653-4q2olzx1 40 22 expression expression NN cord-271653-4q2olzx1 40 23 that that WDT cord-271653-4q2olzx1 40 24 renders render VBZ cord-271653-4q2olzx1 40 25 lesions lesion NNS cord-271653-4q2olzx1 40 26 more more RBR cord-271653-4q2olzx1 40 27 thrombogenic thrombogenic JJ cord-271653-4q2olzx1 40 28 . . . cord-271653-4q2olzx1 41 1 We -PRON- PRP cord-271653-4q2olzx1 41 2 have have VBP cord-271653-4q2olzx1 41 3 referred refer VBN cord-271653-4q2olzx1 41 4 to to IN cord-271653-4q2olzx1 41 5 this this DT cord-271653-4q2olzx1 41 6 local local JJ cord-271653-4q2olzx1 41 7 response response NN cord-271653-4q2olzx1 41 8 to to IN cord-271653-4q2olzx1 41 9 systemic systemic JJ cord-271653-4q2olzx1 41 10 stimuli stimulus NNS cord-271653-4q2olzx1 41 11 as as IN cord-271653-4q2olzx1 41 12 an an DT cord-271653-4q2olzx1 41 13 " " `` cord-271653-4q2olzx1 41 14 echo echo NN cord-271653-4q2olzx1 41 15 " " '' cord-271653-4q2olzx1 41 16 phenomenon phenomenon NN cord-271653-4q2olzx1 41 17 . . . cord-271653-4q2olzx1 42 1 4 4 LS cord-271653-4q2olzx1 42 2 , , , cord-271653-4q2olzx1 42 3 6 6 CD cord-271653-4q2olzx1 42 4 These these DT cord-271653-4q2olzx1 42 5 same same JJ cord-271653-4q2olzx1 42 6 systemic systemic JJ cord-271653-4q2olzx1 42 7 cytokines cytokine NNS cord-271653-4q2olzx1 42 8 can can MD cord-271653-4q2olzx1 42 9 stimulate stimulate VB cord-271653-4q2olzx1 42 10 leukocyte leukocyte NN cord-271653-4q2olzx1 42 11 adhesion adhesion NN cord-271653-4q2olzx1 42 12 molecule molecule NN cord-271653-4q2olzx1 42 13 expression expression NN cord-271653-4q2olzx1 42 14 on on IN cord-271653-4q2olzx1 42 15 the the DT cord-271653-4q2olzx1 42 16 endothelial endothelial JJ cord-271653-4q2olzx1 42 17 cells cell NNS cord-271653-4q2olzx1 42 18 overlying overlie VBG cord-271653-4q2olzx1 42 19 established establish VBN cord-271653-4q2olzx1 42 20 atheroma atheroma NNP cord-271653-4q2olzx1 42 21 , , , cord-271653-4q2olzx1 42 22 boosting boost VBG cord-271653-4q2olzx1 42 23 local local JJ cord-271653-4q2olzx1 42 24 recruitment recruitment NN cord-271653-4q2olzx1 42 25 of of IN cord-271653-4q2olzx1 42 26 these these DT cord-271653-4q2olzx1 42 27 inflammatory inflammatory JJ cord-271653-4q2olzx1 42 28 cells cell NNS cord-271653-4q2olzx1 42 29 . . . cord-271653-4q2olzx1 43 1 These these DT cord-271653-4q2olzx1 43 2 alterations alteration NNS cord-271653-4q2olzx1 43 3 in in IN cord-271653-4q2olzx1 43 4 preexisting preexisting JJ cord-271653-4q2olzx1 43 5 plaques plaque NNS cord-271653-4q2olzx1 43 6 can can MD cord-271653-4q2olzx1 43 7 enhance enhance VB cord-271653-4q2olzx1 43 8 their -PRON- PRP$ cord-271653-4q2olzx1 43 9 propensity propensity NN cord-271653-4q2olzx1 43 10 to to TO cord-271653-4q2olzx1 43 11 disrupt disrupt VB cord-271653-4q2olzx1 43 12 , , , cord-271653-4q2olzx1 43 13 be be VB cord-271653-4q2olzx1 43 14 it -PRON- PRP cord-271653-4q2olzx1 43 15 by by IN cord-271653-4q2olzx1 43 16 fibrous fibrous JJ cord-271653-4q2olzx1 43 17 cap cap NN cord-271653-4q2olzx1 43 18 fissure fissure NN cord-271653-4q2olzx1 43 19 or or CC cord-271653-4q2olzx1 43 20 by by IN cord-271653-4q2olzx1 43 21 superficial superficial JJ cord-271653-4q2olzx1 43 22 erosion erosion NN cord-271653-4q2olzx1 43 23 , , , cord-271653-4q2olzx1 43 24 and and CC cord-271653-4q2olzx1 43 25 provoke provoke VB cord-271653-4q2olzx1 43 26 an an DT cord-271653-4q2olzx1 43 27 acute acute JJ cord-271653-4q2olzx1 43 28 coronary coronary JJ cord-271653-4q2olzx1 43 29 syndrome syndrome NN cord-271653-4q2olzx1 43 30 . . . cord-271653-4q2olzx1 44 1 Even even RB cord-271653-4q2olzx1 44 2 in in IN cord-271653-4q2olzx1 44 3 individuals individual NNS cord-271653-4q2olzx1 44 4 without without IN cord-271653-4q2olzx1 44 5 pre pre JJ cord-271653-4q2olzx1 44 6 - - JJ cord-271653-4q2olzx1 44 7 existing existing JJ cord-271653-4q2olzx1 44 8 epicardial epicardial JJ cord-271653-4q2olzx1 44 9 coronary coronary JJ cord-271653-4q2olzx1 44 10 artery artery NN cord-271653-4q2olzx1 44 11 disease disease NN cord-271653-4q2olzx1 44 12 , , , cord-271653-4q2olzx1 44 13 systemic systemic JJ cord-271653-4q2olzx1 44 14 cytokines cytokine NNS cord-271653-4q2olzx1 44 15 released release VBN cord-271653-4q2olzx1 44 16 from from IN cord-271653-4q2olzx1 44 17 sites site NNS cord-271653-4q2olzx1 44 18 of of IN cord-271653-4q2olzx1 44 19 local local JJ cord-271653-4q2olzx1 44 20 infections infection NNS cord-271653-4q2olzx1 44 21 such such JJ cord-271653-4q2olzx1 44 22 as as IN cord-271653-4q2olzx1 44 23 in in IN cord-271653-4q2olzx1 44 24 pneumonitis pneumonitis NN cord-271653-4q2olzx1 44 25 can can MD cord-271653-4q2olzx1 44 26 affect affect VB cord-271653-4q2olzx1 44 27 intermural intermural JJ cord-271653-4q2olzx1 44 28 coronary coronary JJ cord-271653-4q2olzx1 44 29 vessels vessel NNS cord-271653-4q2olzx1 44 30 . . . cord-271653-4q2olzx1 45 1 They -PRON- PRP cord-271653-4q2olzx1 45 2 also also RB cord-271653-4q2olzx1 45 3 can can MD cord-271653-4q2olzx1 45 4 activate activate VB cord-271653-4q2olzx1 45 5 the the DT cord-271653-4q2olzx1 45 6 microvascular microvascular JJ cord-271653-4q2olzx1 45 7 endothelium endothelium NN cord-271653-4q2olzx1 45 8 , , , cord-271653-4q2olzx1 45 9 predisposing predispose VBG cord-271653-4q2olzx1 45 10 to to IN cord-271653-4q2olzx1 45 11 vasomotor vasomotor NN cord-271653-4q2olzx1 45 12 abnormalities abnormality NNS cord-271653-4q2olzx1 45 13 , , , cord-271653-4q2olzx1 45 14 augmented augment VBN cord-271653-4q2olzx1 45 15 thrombosis thrombosis NN cord-271653-4q2olzx1 45 16 , , , cord-271653-4q2olzx1 45 17 reduced reduce VBN cord-271653-4q2olzx1 45 18 fibrinolysis fibrinolysis NN cord-271653-4q2olzx1 45 19 , , , cord-271653-4q2olzx1 45 20 increased increase VBN cord-271653-4q2olzx1 45 21 leukocyte leukocyte NN cord-271653-4q2olzx1 45 22 adhesion adhesion NN cord-271653-4q2olzx1 45 23 , , , cord-271653-4q2olzx1 45 24 and and CC cord-271653-4q2olzx1 45 25 other other JJ cord-271653-4q2olzx1 45 26 aspects aspect NNS cord-271653-4q2olzx1 45 27 of of IN cord-271653-4q2olzx1 45 28 dysfunction dysfunction NN cord-271653-4q2olzx1 45 29 of of IN cord-271653-4q2olzx1 45 30 the the DT cord-271653-4q2olzx1 45 31 microvessels microvessel NNS cord-271653-4q2olzx1 45 32 of of IN cord-271653-4q2olzx1 45 33 the the DT cord-271653-4q2olzx1 45 34 coronary coronary JJ cord-271653-4q2olzx1 45 35 circulation circulation NN cord-271653-4q2olzx1 45 36 . . . cord-271653-4q2olzx1 46 1 These these DT cord-271653-4q2olzx1 46 2 effects effect NNS cord-271653-4q2olzx1 46 3 wrought work VBN cord-271653-4q2olzx1 46 4 by by IN cord-271653-4q2olzx1 46 5 distant distant JJ cord-271653-4q2olzx1 46 6 infection infection NN cord-271653-4q2olzx1 46 7 can can MD cord-271653-4q2olzx1 46 8 contribute contribute VB cord-271653-4q2olzx1 46 9 to to IN cord-271653-4q2olzx1 46 10 myocardial myocardial JJ cord-271653-4q2olzx1 46 11 ischemia ischemia NN cord-271653-4q2olzx1 46 12 even even RB cord-271653-4q2olzx1 46 13 in in IN cord-271653-4q2olzx1 46 14 the the DT cord-271653-4q2olzx1 46 15 absence absence NN cord-271653-4q2olzx1 46 16 of of IN cord-271653-4q2olzx1 46 17 epicardial epicardial JJ cord-271653-4q2olzx1 46 18 atherosclerosis atherosclerosis NN cord-271653-4q2olzx1 46 19 , , , cord-271653-4q2olzx1 46 20 and and CC cord-271653-4q2olzx1 46 21 could could MD cord-271653-4q2olzx1 46 22 compound compound VB cord-271653-4q2olzx1 46 23 cardiac cardiac JJ cord-271653-4q2olzx1 46 24 injury injury NN cord-271653-4q2olzx1 46 25 in in IN cord-271653-4q2olzx1 46 26 those those DT cord-271653-4q2olzx1 46 27 with with IN cord-271653-4q2olzx1 46 28 flow flow NN cord-271653-4q2olzx1 46 29 limitation limitation NN cord-271653-4q2olzx1 46 30 due due JJ cord-271653-4q2olzx1 46 31 to to IN cord-271653-4q2olzx1 46 32 plaque plaque NN cord-271653-4q2olzx1 46 33 in in IN cord-271653-4q2olzx1 46 34 the the DT cord-271653-4q2olzx1 46 35 larger large JJR cord-271653-4q2olzx1 46 36 coronary coronary JJ cord-271653-4q2olzx1 46 37 arteries artery NNS cord-271653-4q2olzx1 46 38 . . . cord-271653-4q2olzx1 47 1 The the DT cord-271653-4q2olzx1 47 2 cardinal cardinal JJ cord-271653-4q2olzx1 47 3 signs sign NNS cord-271653-4q2olzx1 47 4 of of IN cord-271653-4q2olzx1 47 5 infection infection NN cord-271653-4q2olzx1 47 6 include include VBP cord-271653-4q2olzx1 47 7 fever fever NN cord-271653-4q2olzx1 47 8 and and CC cord-271653-4q2olzx1 47 9 tachycardia tachycardia NN cord-271653-4q2olzx1 47 10 , , , cord-271653-4q2olzx1 47 11 circumstances circumstance NNS cord-271653-4q2olzx1 47 12 that that WDT cord-271653-4q2olzx1 47 13 increase increase VBP cord-271653-4q2olzx1 47 14 the the DT cord-271653-4q2olzx1 47 15 oxygen oxygen NN cord-271653-4q2olzx1 47 16 requirements requirement NNS cord-271653-4q2olzx1 47 17 of of IN cord-271653-4q2olzx1 47 18 the the DT cord-271653-4q2olzx1 47 19 myocardium myocardium NN cord-271653-4q2olzx1 47 20 ( ( -LRB- cord-271653-4q2olzx1 47 21 Figure figure NN cord-271653-4q2olzx1 47 22 3 3 CD cord-271653-4q2olzx1 47 23 ) ) -RRB- cord-271653-4q2olzx1 47 24 . . . cord-271653-4q2olzx1 48 1 Hypoxemia Hypoxemia NNP cord-271653-4q2olzx1 48 2 produced produce VBN cord-271653-4q2olzx1 48 3 by by IN cord-271653-4q2olzx1 48 4 pneumonitis pneumonitis NN cord-271653-4q2olzx1 48 5 can can MD cord-271653-4q2olzx1 48 6 decrease decrease VB cord-271653-4q2olzx1 48 7 oxygen oxygen NN cord-271653-4q2olzx1 48 8 delivery delivery NN cord-271653-4q2olzx1 48 9 to to IN cord-271653-4q2olzx1 48 10 the the DT cord-271653-4q2olzx1 48 11 myocardium myocardium NN cord-271653-4q2olzx1 48 12 . . . cord-271653-4q2olzx1 49 1 Hypotension hypotension NN cord-271653-4q2olzx1 49 2 in in IN cord-271653-4q2olzx1 49 3 sepsis sepsis NN cord-271653-4q2olzx1 49 4 and and CC cord-271653-4q2olzx1 49 5 in in IN cord-271653-4q2olzx1 49 6 cytokine cytokine NN cord-271653-4q2olzx1 49 7 storm storm NN cord-271653-4q2olzx1 49 8 can can MD cord-271653-4q2olzx1 49 9 impair impair VB cord-271653-4q2olzx1 49 10 coronary coronary JJ cord-271653-4q2olzx1 49 11 perfusion perfusion NN cord-271653-4q2olzx1 49 12 . . . cord-271653-4q2olzx1 50 1 Together together RB cord-271653-4q2olzx1 50 2 these these DT cord-271653-4q2olzx1 50 3 systemic systemic JJ cord-271653-4q2olzx1 50 4 effects effect NNS cord-271653-4q2olzx1 50 5 of of IN cord-271653-4q2olzx1 50 6 infection infection NN cord-271653-4q2olzx1 50 7 conspire conspire VBP cord-271653-4q2olzx1 50 8 to to TO cord-271653-4q2olzx1 50 9 limit limit VB cord-271653-4q2olzx1 50 10 blood blood NN cord-271653-4q2olzx1 50 11 flow flow NN cord-271653-4q2olzx1 50 12 in in IN cord-271653-4q2olzx1 50 13 the the DT cord-271653-4q2olzx1 50 14 coronary coronary JJ cord-271653-4q2olzx1 50 15 arteries artery NNS cord-271653-4q2olzx1 50 16 , , , cord-271653-4q2olzx1 50 17 and and CC cord-271653-4q2olzx1 50 18 reduce reduce VB cord-271653-4q2olzx1 50 19 oxygen oxygen NN cord-271653-4q2olzx1 50 20 supply supply NN cord-271653-4q2olzx1 50 21 while while IN cord-271653-4q2olzx1 50 22 augmenting augment VBG cord-271653-4q2olzx1 50 23 myocardial myocardial JJ cord-271653-4q2olzx1 50 24 oxygen oxygen NN cord-271653-4q2olzx1 50 25 demand demand NN cord-271653-4q2olzx1 50 26 . . . cord-271653-4q2olzx1 51 1 These these DT cord-271653-4q2olzx1 51 2 consequences consequence NNS cord-271653-4q2olzx1 51 3 of of IN cord-271653-4q2olzx1 51 4 infection infection NN cord-271653-4q2olzx1 51 5 predispose predispose VBP cord-271653-4q2olzx1 51 6 to to IN cord-271653-4q2olzx1 51 7 myocardial myocardial JJ cord-271653-4q2olzx1 51 8 ischemia ischemia NN cord-271653-4q2olzx1 51 9 . . . cord-271653-4q2olzx1 52 1 They -PRON- PRP cord-271653-4q2olzx1 52 2 may may MD cord-271653-4q2olzx1 52 3 aggravate aggravate VB cord-271653-4q2olzx1 52 4 the the DT cord-271653-4q2olzx1 52 5 consequences consequence NNS cord-271653-4q2olzx1 52 6 of of IN cord-271653-4q2olzx1 52 7 plaques plaque NNS cord-271653-4q2olzx1 52 8 that that WDT cord-271653-4q2olzx1 52 9 would would MD cord-271653-4q2olzx1 52 10 not not RB cord-271653-4q2olzx1 52 11 limit limit VB cord-271653-4q2olzx1 52 12 flow flow NN cord-271653-4q2olzx1 52 13 or or CC cord-271653-4q2olzx1 52 14 provoke provoke VB cord-271653-4q2olzx1 52 15 ischemia ischemia NN cord-271653-4q2olzx1 52 16 under under IN cord-271653-4q2olzx1 52 17 usual usual JJ cord-271653-4q2olzx1 52 18 conditions condition NNS cord-271653-4q2olzx1 52 19 , , , cord-271653-4q2olzx1 52 20 and and CC cord-271653-4q2olzx1 52 21 could could MD cord-271653-4q2olzx1 52 22 produce produce VB cord-271653-4q2olzx1 52 23 ischemic ischemic JJ cord-271653-4q2olzx1 52 24 injury injury NN cord-271653-4q2olzx1 52 25 even even RB cord-271653-4q2olzx1 52 26 in in IN cord-271653-4q2olzx1 52 27 those those DT cord-271653-4q2olzx1 52 28 with with IN cord-271653-4q2olzx1 52 29 little little JJ cord-271653-4q2olzx1 52 30 or or CC cord-271653-4q2olzx1 52 31 no no DT cord-271653-4q2olzx1 52 32 coronary coronary JJ cord-271653-4q2olzx1 52 33 artery artery NN cord-271653-4q2olzx1 52 34 atherosclerosis atherosclerosis NN cord-271653-4q2olzx1 52 35 . . . cord-271653-4q2olzx1 53 1 At at IN cord-271653-4q2olzx1 53 2 one one CD cord-271653-4q2olzx1 53 3 end end NN cord-271653-4q2olzx1 53 4 of of IN cord-271653-4q2olzx1 53 5 the the DT cord-271653-4q2olzx1 53 6 spectrum spectrum NN cord-271653-4q2olzx1 53 7 , , , cord-271653-4q2olzx1 53 8 a a DT cord-271653-4q2olzx1 53 9 young young JJ cord-271653-4q2olzx1 53 10 individual individual NN cord-271653-4q2olzx1 53 11 with with IN cord-271653-4q2olzx1 53 12 pristine pristine JJ cord-271653-4q2olzx1 53 13 coronary coronary JJ cord-271653-4q2olzx1 53 14 arteries artery NNS cord-271653-4q2olzx1 53 15 might may MD cord-271653-4q2olzx1 53 16 suffer suffer VB cord-271653-4q2olzx1 53 17 severe severe JJ cord-271653-4q2olzx1 53 18 myocardial myocardial JJ cord-271653-4q2olzx1 53 19 injury injury NN cord-271653-4q2olzx1 53 20 due due IN cord-271653-4q2olzx1 53 21 to to IN cord-271653-4q2olzx1 53 22 a a DT cord-271653-4q2olzx1 53 23 fulminant fulminant JJ cord-271653-4q2olzx1 53 24 myocarditis myocarditis NN cord-271653-4q2olzx1 53 25 caused cause VBN cord-271653-4q2olzx1 53 26 by by IN cord-271653-4q2olzx1 53 27 direct direct JJ cord-271653-4q2olzx1 53 28 infection infection NN cord-271653-4q2olzx1 53 29 with with IN cord-271653-4q2olzx1 53 30 COVID-19 COVID-19 NNP cord-271653-4q2olzx1 53 31 ( ( -LRB- cord-271653-4q2olzx1 53 32 Figure figure NN cord-271653-4q2olzx1 53 33 1 1 CD cord-271653-4q2olzx1 53 34 , , , cord-271653-4q2olzx1 53 35 left leave VBN cord-271653-4q2olzx1 53 36 ) ) -RRB- cord-271653-4q2olzx1 53 37 . . . cord-271653-4q2olzx1 54 1 At at IN cord-271653-4q2olzx1 54 2 the the DT cord-271653-4q2olzx1 54 3 other other JJ cord-271653-4q2olzx1 54 4 extreme extreme NN cord-271653-4q2olzx1 54 5 , , , cord-271653-4q2olzx1 54 6 a a DT cord-271653-4q2olzx1 54 7 person person NN cord-271653-4q2olzx1 54 8 with with IN cord-271653-4q2olzx1 54 9 advanced advanced JJ cord-271653-4q2olzx1 54 10 coronary coronary JJ cord-271653-4q2olzx1 54 11 atherosclerosis atherosclerosis NN cord-271653-4q2olzx1 54 12 could could MD cord-271653-4q2olzx1 54 13 suffer suffer VB cord-271653-4q2olzx1 54 14 a a DT cord-271653-4q2olzx1 54 15 type type NN cord-271653-4q2olzx1 54 16 1 1 CD cord-271653-4q2olzx1 54 17 or or CC cord-271653-4q2olzx1 54 18 type type NN cord-271653-4q2olzx1 54 19 2 2 CD cord-271653-4q2olzx1 54 20 acute acute JJ cord-271653-4q2olzx1 54 21 myocardial myocardial JJ cord-271653-4q2olzx1 54 22 infarction infarction NN cord-271653-4q2olzx1 54 23 without without IN cord-271653-4q2olzx1 54 24 direct direct JJ cord-271653-4q2olzx1 54 25 viral viral JJ cord-271653-4q2olzx1 54 26 infection infection NN cord-271653-4q2olzx1 54 27 of of IN cord-271653-4q2olzx1 54 28 cardiac cardiac JJ cord-271653-4q2olzx1 54 29 cells cell NNS cord-271653-4q2olzx1 54 30 ( ( -LRB- cord-271653-4q2olzx1 54 31 Figure figure NN cord-271653-4q2olzx1 54 32 1 1 CD cord-271653-4q2olzx1 54 33 , , , cord-271653-4q2olzx1 54 34 right right RB cord-271653-4q2olzx1 54 35 ) ) -RRB- cord-271653-4q2olzx1 54 36 . . . cord-271653-4q2olzx1 55 1 Although although IN cord-271653-4q2olzx1 55 2 we -PRON- PRP cord-271653-4q2olzx1 55 3 are be VBP cord-271653-4q2olzx1 55 4 early early JJ cord-271653-4q2olzx1 55 5 in in IN cord-271653-4q2olzx1 55 6 our -PRON- PRP$ cord-271653-4q2olzx1 55 7 experience experience NN cord-271653-4q2olzx1 55 8 with with IN cord-271653-4q2olzx1 55 9 this this DT cord-271653-4q2olzx1 55 10 novel novel JJ cord-271653-4q2olzx1 55 11 coronavirus coronavirus NN cord-271653-4q2olzx1 55 12 disease disease NN cord-271653-4q2olzx1 55 13 , , , cord-271653-4q2olzx1 55 14 most most JJS cord-271653-4q2olzx1 55 15 patients patient NNS cord-271653-4q2olzx1 55 16 affected affect VBN cord-271653-4q2olzx1 55 17 by by IN cord-271653-4q2olzx1 55 18 COVID-19 COVID-19 NNP cord-271653-4q2olzx1 55 19 encountered encounter VBN cord-271653-4q2olzx1 55 20 by by IN cord-271653-4q2olzx1 55 21 cardiologists cardiologist NNS cord-271653-4q2olzx1 55 22 may may MD cord-271653-4q2olzx1 55 23 have have VB cord-271653-4q2olzx1 55 24 more more JJR cord-271653-4q2olzx1 55 25 secondary secondary JJ cord-271653-4q2olzx1 55 26 cardiac cardiac JJ cord-271653-4q2olzx1 55 27 involvement involvement NN cord-271653-4q2olzx1 55 28 then then RB cord-271653-4q2olzx1 55 29 primary primary JJ cord-271653-4q2olzx1 55 30 infective infective JJ cord-271653-4q2olzx1 55 31 myocarditis myocarditis NN cord-271653-4q2olzx1 55 32 . . . cord-271653-4q2olzx1 56 1 Thus thus RB cord-271653-4q2olzx1 56 2 , , , cord-271653-4q2olzx1 56 3 many many JJ cord-271653-4q2olzx1 56 4 of of IN cord-271653-4q2olzx1 56 5 our -PRON- PRP$ cord-271653-4q2olzx1 56 6 patients patient NNS cord-271653-4q2olzx1 56 7 may may MD cord-271653-4q2olzx1 56 8 fall fall VB cord-271653-4q2olzx1 56 9 into into IN cord-271653-4q2olzx1 56 10 the the DT cord-271653-4q2olzx1 56 11 zone zone NN cord-271653-4q2olzx1 56 12 between between IN cord-271653-4q2olzx1 56 13 the the DT cord-271653-4q2olzx1 56 14 two two CD cord-271653-4q2olzx1 56 15 bookends bookend NNS cord-271653-4q2olzx1 56 16 depicted depict VBN cord-271653-4q2olzx1 56 17 in in IN cord-271653-4q2olzx1 56 18 Figure Figure NNP cord-271653-4q2olzx1 56 19 1 1 CD cord-271653-4q2olzx1 56 20 . . . cord-271653-4q2olzx1 57 1 It -PRON- PRP cord-271653-4q2olzx1 57 2 behooves behooves VBP cord-271653-4q2olzx1 57 3 us -PRON- PRP cord-271653-4q2olzx1 57 4 to to TO cord-271653-4q2olzx1 57 5 consider consider VB cord-271653-4q2olzx1 57 6 the the DT cord-271653-4q2olzx1 57 7 multiple multiple JJ cord-271653-4q2olzx1 57 8 mechanisms mechanism NNS cord-271653-4q2olzx1 57 9 of of IN cord-271653-4q2olzx1 57 10 cardiac cardiac JJ cord-271653-4q2olzx1 57 11 injury injury NN cord-271653-4q2olzx1 57 12 in in IN cord-271653-4q2olzx1 57 13 patients patient NNS cord-271653-4q2olzx1 57 14 with with IN cord-271653-4q2olzx1 57 15 COVID-19 COVID-19 NNP cord-271653-4q2olzx1 57 16 disease disease NN cord-271653-4q2olzx1 57 17 ( ( -LRB- cord-271653-4q2olzx1 57 18 Figure figure NN cord-271653-4q2olzx1 57 19 4 4 CD cord-271653-4q2olzx1 57 20 ) ) -RRB- cord-271653-4q2olzx1 57 21 . . . cord-271653-4q2olzx1 58 1 As as IN cord-271653-4q2olzx1 58 2 in in IN cord-271653-4q2olzx1 58 3 the the DT cord-271653-4q2olzx1 58 4 BC BC NNP cord-271653-4q2olzx1 58 5 ( ( -LRB- cord-271653-4q2olzx1 58 6 before before IN cord-271653-4q2olzx1 58 7 COVID COVID NNP cord-271653-4q2olzx1 58 8 ) ) -RRB- cord-271653-4q2olzx1 58 9 era era NN cord-271653-4q2olzx1 58 10 , , , cord-271653-4q2olzx1 58 11 interpretation interpretation NN cord-271653-4q2olzx1 58 12 of of IN cord-271653-4q2olzx1 58 13 rises rise NNS cord-271653-4q2olzx1 58 14 in in IN cord-271653-4q2olzx1 58 15 cardiac cardiac JJ cord-271653-4q2olzx1 58 16 troponin troponin NN cord-271653-4q2olzx1 58 17 requires require VBZ cord-271653-4q2olzx1 58 18 consideration consideration NN cord-271653-4q2olzx1 58 19 of of IN cord-271653-4q2olzx1 58 20 the the DT cord-271653-4q2olzx1 58 21 context context NN cord-271653-4q2olzx1 58 22 of of IN cord-271653-4q2olzx1 58 23 the the DT cord-271653-4q2olzx1 58 24 clinical clinical JJ cord-271653-4q2olzx1 58 25 situation situation NN cord-271653-4q2olzx1 58 26 . . . cord-271653-4q2olzx1 59 1 Not not RB cord-271653-4q2olzx1 59 2 all all DT cord-271653-4q2olzx1 59 3 rises rise VBZ cord-271653-4q2olzx1 59 4 in in IN cord-271653-4q2olzx1 59 5 this this DT cord-271653-4q2olzx1 59 6 biomarker biomarker NN cord-271653-4q2olzx1 59 7 of of IN cord-271653-4q2olzx1 59 8 cardiac cardiac JJ cord-271653-4q2olzx1 59 9 injury injury NN cord-271653-4q2olzx1 59 10 will will MD cord-271653-4q2olzx1 59 11 result result VB cord-271653-4q2olzx1 59 12 from from IN cord-271653-4q2olzx1 59 13 coronary coronary JJ cord-271653-4q2olzx1 59 14 artery artery NN cord-271653-4q2olzx1 59 15 disease disease NN cord-271653-4q2olzx1 59 16 requiring require VBG cord-271653-4q2olzx1 59 17 invasive invasive JJ cord-271653-4q2olzx1 59 18 assessment assessment NN cord-271653-4q2olzx1 59 19 or or CC cord-271653-4q2olzx1 59 20 intervention intervention NN cord-271653-4q2olzx1 59 21 . . . cord-271653-4q2olzx1 60 1 We -PRON- PRP cord-271653-4q2olzx1 60 2 urgently urgently RB cord-271653-4q2olzx1 60 3 need need VBP cord-271653-4q2olzx1 60 4 randomized randomized JJ cord-271653-4q2olzx1 60 5 clinical clinical JJ cord-271653-4q2olzx1 60 6 trials trial NNS cord-271653-4q2olzx1 60 7 to to TO cord-271653-4q2olzx1 60 8 assess assess VB cord-271653-4q2olzx1 60 9 the the DT cord-271653-4q2olzx1 60 10 value value NN cord-271653-4q2olzx1 60 11 of of IN cord-271653-4q2olzx1 60 12 interventions intervention NNS cord-271653-4q2olzx1 60 13 including include VBG cord-271653-4q2olzx1 60 14 anti anti JJ cord-271653-4q2olzx1 60 15 - - JJ cord-271653-4q2olzx1 60 16 inflammatory inflammatory JJ cord-271653-4q2olzx1 60 17 therapies therapy NNS cord-271653-4q2olzx1 60 18 ranging range VBG cord-271653-4q2olzx1 60 19 from from IN cord-271653-4q2olzx1 60 20 glucocorticoids glucocorticoid NNS cord-271653-4q2olzx1 60 21 to to IN cord-271653-4q2olzx1 60 22 cytokine cytokine JJ cord-271653-4q2olzx1 60 23 antagonism antagonism NN cord-271653-4q2olzx1 60 24 in in IN cord-271653-4q2olzx1 60 25 addition addition NN cord-271653-4q2olzx1 60 26 to to IN cord-271653-4q2olzx1 60 27 antiviral antiviral JJ cord-271653-4q2olzx1 60 28 agents agent NNS cord-271653-4q2olzx1 60 29 as as IN cord-271653-4q2olzx1 60 30 outlined outline VBN cord-271653-4q2olzx1 60 31 in in IN cord-271653-4q2olzx1 60 32 the the DT cord-271653-4q2olzx1 60 33 elegant elegant JJ cord-271653-4q2olzx1 60 34 exposition exposition NN cord-271653-4q2olzx1 60 35 of of IN cord-271653-4q2olzx1 60 36 Atri Atri NNP cord-271653-4q2olzx1 60 37 et et FW cord-271653-4q2olzx1 60 38 al al NNP cord-271653-4q2olzx1 60 39 . . . cord-271653-4q2olzx1 61 1 3 3 LS cord-271653-4q2olzx1 62 1 Dealing deal VBG cord-271653-4q2olzx1 62 2 with with IN cord-271653-4q2olzx1 62 3 the the DT cord-271653-4q2olzx1 62 4 immense immense JJ cord-271653-4q2olzx1 62 5 challenge challenge NN cord-271653-4q2olzx1 62 6 of of IN cord-271653-4q2olzx1 62 7 COVID-19 COVID-19 NNP cord-271653-4q2olzx1 62 8 disease disease NN cord-271653-4q2olzx1 62 9 , , , cord-271653-4q2olzx1 62 10 and and CC cord-271653-4q2olzx1 62 11 confronted confront VBN cord-271653-4q2olzx1 62 12 with with IN cord-271653-4q2olzx1 62 13 severely severely RB cord-271653-4q2olzx1 62 14 ill ill JJ cord-271653-4q2olzx1 62 15 patients patient NNS cord-271653-4q2olzx1 62 16 in in IN cord-271653-4q2olzx1 62 17 dire dire JJ cord-271653-4q2olzx1 62 18 straits strait NNS cord-271653-4q2olzx1 62 19 with with IN cord-271653-4q2olzx1 62 20 virtually virtually RB cord-271653-4q2olzx1 62 21 no no DT cord-271653-4q2olzx1 62 22 rigorous rigorous JJ cord-271653-4q2olzx1 62 23 evidence evidence NN cord-271653-4q2olzx1 62 24 base base NN cord-271653-4q2olzx1 62 25 to to TO cord-271653-4q2olzx1 62 26 guide guide VB cord-271653-4q2olzx1 62 27 our -PRON- PRP$ cord-271653-4q2olzx1 62 28 therapy therapy NN cord-271653-4q2olzx1 62 29 , , , cord-271653-4q2olzx1 62 30 we -PRON- PRP cord-271653-4q2olzx1 62 31 need need VBP cord-271653-4q2olzx1 62 32 to to TO cord-271653-4q2olzx1 62 33 call call VB cord-271653-4q2olzx1 62 34 upon upon IN cord-271653-4q2olzx1 62 35 our -PRON- PRP$ cord-271653-4q2olzx1 62 36 clinical clinical JJ cord-271653-4q2olzx1 62 37 skills skill NNS cord-271653-4q2olzx1 62 38 and and CC cord-271653-4q2olzx1 62 39 judgment judgment NN cord-271653-4q2olzx1 62 40 . . . cord-271653-4q2olzx1 63 1 These these DT cord-271653-4q2olzx1 63 2 touchstones touchstone NNS cord-271653-4q2olzx1 63 3 can can MD cord-271653-4q2olzx1 63 4 help help VB cord-271653-4q2olzx1 63 5 guide guide VB cord-271653-4q2olzx1 63 6 us -PRON- PRP cord-271653-4q2olzx1 63 7 in in IN cord-271653-4q2olzx1 63 8 selecting select VBG cord-271653-4q2olzx1 63 9 patients patient NNS cord-271653-4q2olzx1 63 10 who who WP cord-271653-4q2olzx1 63 11 might may MD cord-271653-4q2olzx1 63 12 benefit benefit VB cord-271653-4q2olzx1 63 13 from from IN cord-271653-4q2olzx1 63 14 the the DT cord-271653-4q2olzx1 63 15 advanced advanced JJ cord-271653-4q2olzx1 63 16 imaging imaging NN cord-271653-4q2olzx1 63 17 and and CC cord-271653-4q2olzx1 63 18 invasive invasive JJ cord-271653-4q2olzx1 63 19 procedures procedure NNS cord-271653-4q2olzx1 63 20 that that WDT cord-271653-4q2olzx1 63 21 present present VBP cord-271653-4q2olzx1 63 22 enormous enormous JJ cord-271653-4q2olzx1 63 23 logistical logistical JJ cord-271653-4q2olzx1 63 24 challenges challenge NNS cord-271653-4q2olzx1 63 25 in in IN cord-271653-4q2olzx1 63 26 the the DT cord-271653-4q2olzx1 63 27 current current JJ cord-271653-4q2olzx1 63 28 context context NN cord-271653-4q2olzx1 63 29 . . . cord-271653-4q2olzx1 64 1 In in IN cord-271653-4q2olzx1 64 2 the the DT cord-271653-4q2olzx1 64 3 absence absence NN cord-271653-4q2olzx1 64 4 of of IN cord-271653-4q2olzx1 64 5 a a DT cord-271653-4q2olzx1 64 6 robust robust JJ cord-271653-4q2olzx1 64 7 evidence evidence NN cord-271653-4q2olzx1 64 8 base base NN cord-271653-4q2olzx1 64 9 , , , cord-271653-4q2olzx1 64 10 we -PRON- PRP cord-271653-4q2olzx1 64 11 will will MD cord-271653-4q2olzx1 64 12 also also RB cord-271653-4q2olzx1 64 13 need need VB cord-271653-4q2olzx1 64 14 to to TO cord-271653-4q2olzx1 64 15 invoke invoke VB cord-271653-4q2olzx1 64 16 pathophysiologic pathophysiologic JJ cord-271653-4q2olzx1 64 17 reasoning reason VBG cord-271653-4q2olzx1 64 18 to to TO cord-271653-4q2olzx1 64 19 guide guide VB cord-271653-4q2olzx1 64 20 our -PRON- PRP$ cord-271653-4q2olzx1 64 21 choices choice NNS cord-271653-4q2olzx1 64 22 of of IN cord-271653-4q2olzx1 64 23 therapy therapy NN cord-271653-4q2olzx1 64 24 for for IN cord-271653-4q2olzx1 64 25 each each DT cord-271653-4q2olzx1 64 26 individual individual JJ cord-271653-4q2olzx1 64 27 clinical clinical JJ cord-271653-4q2olzx1 64 28 scenario scenario NN cord-271653-4q2olzx1 64 29 . . . cord-271653-4q2olzx1 65 1 We -PRON- PRP cord-271653-4q2olzx1 65 2 must must MD cord-271653-4q2olzx1 65 3 do do VB cord-271653-4q2olzx1 65 4 so so RB cord-271653-4q2olzx1 65 5 with with IN cord-271653-4q2olzx1 65 6 caution caution NN cord-271653-4q2olzx1 65 7 and and CC cord-271653-4q2olzx1 65 8 extreme extreme JJ cord-271653-4q2olzx1 65 9 humility humility NN cord-271653-4q2olzx1 65 10 , , , cord-271653-4q2olzx1 65 11 recognizing recognize VBG cord-271653-4q2olzx1 65 12 how how WRB cord-271653-4q2olzx1 65 13 often often RB cord-271653-4q2olzx1 65 14 plausible plausible JJ cord-271653-4q2olzx1 65 15 interventions intervention NNS cord-271653-4q2olzx1 65 16 fail fail VBP cord-271653-4q2olzx1 65 17 when when WRB cord-271653-4q2olzx1 65 18 tested test VBN cord-271653-4q2olzx1 65 19 rigorously rigorously RB cord-271653-4q2olzx1 65 20 . . . cord-271653-4q2olzx1 66 1 But but CC cord-271653-4q2olzx1 66 2 act act VB cord-271653-4q2olzx1 66 3 today today NN cord-271653-4q2olzx1 66 4 we -PRON- PRP cord-271653-4q2olzx1 66 5 must must MD cord-271653-4q2olzx1 66 6 , , , cord-271653-4q2olzx1 66 7 and and CC cord-271653-4q2olzx1 66 8 the the DT cord-271653-4q2olzx1 66 9 overview overview NN cord-271653-4q2olzx1 66 10 of of IN cord-271653-4q2olzx1 66 11 Atri Atri NNP cord-271653-4q2olzx1 66 12 et et FW cord-271653-4q2olzx1 66 13 al al NNP cord-271653-4q2olzx1 66 14 . . . cord-271653-4q2olzx1 66 15 and and CC cord-271653-4q2olzx1 66 16 other other JJ cord-271653-4q2olzx1 66 17 recent recent JJ cord-271653-4q2olzx1 66 18 compendia compendia NNS cord-271653-4q2olzx1 66 19 will will MD cord-271653-4q2olzx1 66 20 help help VB cord-271653-4q2olzx1 66 21 us -PRON- PRP cord-271653-4q2olzx1 66 22 meet meet VB cord-271653-4q2olzx1 66 23 our -PRON- PRP$ cord-271653-4q2olzx1 66 24 mission mission NN cord-271653-4q2olzx1 66 25 unsupported unsupported JJ cord-271653-4q2olzx1 66 26 by by IN cord-271653-4q2olzx1 66 27 the the DT cord-271653-4q2olzx1 66 28 comfort comfort NN cord-271653-4q2olzx1 66 29 of of IN cord-271653-4q2olzx1 66 30 strong strong JJ cord-271653-4q2olzx1 66 31 data datum NNS cord-271653-4q2olzx1 66 32 . . . cord-271653-4q2olzx1 67 1 3 3 CD cord-271653-4q2olzx1 67 2 _SP cord-271653-4q2olzx1 68 1 Coronavirus Coronavirus NNP cord-271653-4q2olzx1 68 2 fulminant fulminant JJ cord-271653-4q2olzx1 68 3 myocarditis myocarditis NN cord-271653-4q2olzx1 68 4 treated treat VBN cord-271653-4q2olzx1 68 5 with with IN cord-271653-4q2olzx1 68 6 glucocorticoid glucocorticoid NN cord-271653-4q2olzx1 68 7 and and CC cord-271653-4q2olzx1 68 8 human human JJ cord-271653-4q2olzx1 68 9 immunoglobulin immunoglobulin NN cord-271653-4q2olzx1 68 10 Cardiac Cardiac NNP cord-271653-4q2olzx1 68 11 Involvement Involvement NNP cord-271653-4q2olzx1 68 12 in in IN cord-271653-4q2olzx1 68 13 a a DT cord-271653-4q2olzx1 68 14 Patient patient NN cord-271653-4q2olzx1 68 15 With with IN cord-271653-4q2olzx1 68 16 Coronavirus Coronavirus NNP cord-271653-4q2olzx1 68 17 Disease Disease NNP cord-271653-4q2olzx1 68 18 2019 2019 CD cord-271653-4q2olzx1 68 19 ( ( -LRB- cord-271653-4q2olzx1 68 20 COVID-19 COVID-19 NNP cord-271653-4q2olzx1 68 21 ) ) -RRB- cord-271653-4q2olzx1 68 22 COVID-19 COVID-19 VBD cord-271653-4q2olzx1 68 23 for for IN cord-271653-4q2olzx1 68 24 the the DT cord-271653-4q2olzx1 68 25 Cardiologist Cardiologist NNP cord-271653-4q2olzx1 68 26 : : : cord-271653-4q2olzx1 68 27 A a DT cord-271653-4q2olzx1 68 28 State state NN cord-271653-4q2olzx1 68 29 - - HYPH cord-271653-4q2olzx1 68 30 of of IN cord-271653-4q2olzx1 68 31 - - HYPH cord-271653-4q2olzx1 68 32 the the DT cord-271653-4q2olzx1 68 33 - - HYPH cord-271653-4q2olzx1 68 34 Art Art NNP cord-271653-4q2olzx1 68 35 Review Review NNP cord-271653-4q2olzx1 68 36 of of IN cord-271653-4q2olzx1 68 37 the the DT cord-271653-4q2olzx1 68 38 Virology Virology NNP cord-271653-4q2olzx1 68 39 , , , cord-271653-4q2olzx1 68 40 Clinical Clinical NNP cord-271653-4q2olzx1 68 41 Epidemiology Epidemiology NNP cord-271653-4q2olzx1 68 42 , , , cord-271653-4q2olzx1 68 43 Cardiac Cardiac NNP cord-271653-4q2olzx1 68 44 and and CC cord-271653-4q2olzx1 68 45 Other Other NNP cord-271653-4q2olzx1 68 46 Clinical Clinical NNP cord-271653-4q2olzx1 68 47 Manifestations Manifestations NNPS cord-271653-4q2olzx1 68 48 and and CC cord-271653-4q2olzx1 68 49 Potential potential JJ cord-271653-4q2olzx1 68 50 Therapeutic therapeutic JJ cord-271653-4q2olzx1 68 51 Strategies strategy NNS cord-271653-4q2olzx1 68 52 . . . cord-271653-4q2olzx1 69 1 JACC JACC NNP cord-271653-4q2olzx1 69 2 : : : cord-271653-4q2olzx1 70 1 Basic basic JJ cord-271653-4q2olzx1 70 2 to to IN cord-271653-4q2olzx1 70 3 Translational Translational NNP cord-271653-4q2olzx1 70 4 Science Science NNP cord-271653-4q2olzx1 70 5 Roles Roles NNPS cord-271653-4q2olzx1 70 6 of of IN cord-271653-4q2olzx1 70 7 infectious infectious JJ cord-271653-4q2olzx1 70 8 agents agent NNS cord-271653-4q2olzx1 70 9 in in IN cord-271653-4q2olzx1 70 10 atherosclerosis atherosclerosis NN cord-271653-4q2olzx1 70 11 and and CC cord-271653-4q2olzx1 70 12 restenosis restenosis NN cord-271653-4q2olzx1 70 13 : : : cord-271653-4q2olzx1 70 14 an an DT cord-271653-4q2olzx1 70 15 assessment assessment NN cord-271653-4q2olzx1 70 16 of of IN cord-271653-4q2olzx1 70 17 the the DT cord-271653-4q2olzx1 70 18 evidence evidence NN cord-271653-4q2olzx1 70 19 and and CC cord-271653-4q2olzx1 70 20 need need NN cord-271653-4q2olzx1 70 21 for for IN cord-271653-4q2olzx1 70 22 future future JJ cord-271653-4q2olzx1 70 23 research research NN cord-271653-4q2olzx1 70 24 Inflammation inflammation NN cord-271653-4q2olzx1 70 25 , , , cord-271653-4q2olzx1 70 26 Immunity Immunity NNP cord-271653-4q2olzx1 70 27 , , , cord-271653-4q2olzx1 70 28 and and CC cord-271653-4q2olzx1 70 29 Infection infection NN cord-271653-4q2olzx1 70 30 in in IN cord-271653-4q2olzx1 70 31 Atherothrombosis Atherothrombosis NNP cord-271653-4q2olzx1 70 32 : : : cord-271653-4q2olzx1 71 1 JACC JACC NNP cord-271653-4q2olzx1 71 2 Review Review NNP cord-271653-4q2olzx1 71 3 Topic Topic NNP cord-271653-4q2olzx1 71 4 of of IN cord-271653-4q2olzx1 71 5 the the DT cord-271653-4q2olzx1 71 6 Week Week NNP cord-271653-4q2olzx1 71 7 Leukocytes Leukocytes NNPS cord-271653-4q2olzx1 71 8 Link Link NNP cord-271653-4q2olzx1 71 9 Local local JJ cord-271653-4q2olzx1 71 10 and and CC cord-271653-4q2olzx1 71 11 Systemic systemic JJ cord-271653-4q2olzx1 71 12 Inflammation inflammation NN cord-271653-4q2olzx1 71 13 in in IN cord-271653-4q2olzx1 71 14 Ischemic Ischemic NNP cord-271653-4q2olzx1 71 15 Cardiovascular Cardiovascular NNP cord-271653-4q2olzx1 71 16 Disease Disease NNP