id	sid	tid	token	lemma	pos
cord-270892-ycc3csyh	1	1	key	key	NN
cord-270892-ycc3csyh	1	2	:	:	:
cord-270892-ycc3csyh	1	3	cord-270892-ycc3csyh	cord-270892-ycc3csyh	NNP
cord-270892-ycc3csyh	1	4	authors	author	NNS
cord-270892-ycc3csyh	1	5	:	:	:
cord-270892-ycc3csyh	2	1	Rollinger	Rollinger	NNP
cord-270892-ycc3csyh	2	2	,	,	,
cord-270892-ycc3csyh	2	3	Judith	Judith	NNP
cord-270892-ycc3csyh	2	4	M.	M.	NNP
cord-270892-ycc3csyh	2	5	;	;	:
cord-270892-ycc3csyh	2	6	Schmidtke	Schmidtke	NNP
cord-270892-ycc3csyh	2	7	,	,	,
cord-270892-ycc3csyh	3	1	Michaela	Michaela	NNP
cord-270892-ycc3csyh	3	2	title	title	NN
cord-270892-ycc3csyh	3	3	:	:	:
cord-270892-ycc3csyh	3	4	The	the	DT
cord-270892-ycc3csyh	3	5	human	human	JJ
cord-270892-ycc3csyh	3	6	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	3	7	:	:	:
cord-270892-ycc3csyh	3	8	human‐pathological	human‐pathological	JJ
cord-270892-ycc3csyh	3	9	impact	impact	NN
cord-270892-ycc3csyh	3	10	,	,	,
cord-270892-ycc3csyh	3	11	mechanisms	mechanism	NNS
cord-270892-ycc3csyh	3	12	of	of	IN
cord-270892-ycc3csyh	3	13	antirhinoviral	antirhinoviral	JJ
cord-270892-ycc3csyh	3	14	agents	agent	NNS
cord-270892-ycc3csyh	3	15	,	,	,
cord-270892-ycc3csyh	3	16	and	and	CC
cord-270892-ycc3csyh	3	17	strategies	strategy	NNS
cord-270892-ycc3csyh	3	18	for	for	IN
cord-270892-ycc3csyh	3	19	their	-PRON-	PRP$
cord-270892-ycc3csyh	3	20	discovery	discovery	NN
cord-270892-ycc3csyh	3	21	date	date	NN
cord-270892-ycc3csyh	3	22	:	:	:
cord-270892-ycc3csyh	3	23	2010	2010	CD
cord-270892-ycc3csyh	3	24	-	-	SYM
cord-270892-ycc3csyh	3	25	12	12	CD
cord-270892-ycc3csyh	3	26	-	-	SYM
cord-270892-ycc3csyh	3	27	13	13	CD
cord-270892-ycc3csyh	3	28	journal	journal	NN
cord-270892-ycc3csyh	3	29	:	:	:
cord-270892-ycc3csyh	3	30	Med	Med	NNP
cord-270892-ycc3csyh	3	31	Res	Res	NNP
cord-270892-ycc3csyh	3	32	Rev	Rev	NNP
cord-270892-ycc3csyh	3	33	DOI	DOI	NNP
cord-270892-ycc3csyh	3	34	:	:	:
cord-270892-ycc3csyh	3	35	10.1002	10.1002	CD
cord-270892-ycc3csyh	3	36	/	/	SYM
cord-270892-ycc3csyh	3	37	med.20176	med.20176	NN
cord-270892-ycc3csyh	3	38	sha	sha	NNP
cord-270892-ycc3csyh	3	39	:	:	:
cord-270892-ycc3csyh	4	1	6b39f8f058461153fe2a048c4125332aaf4274e2	6b39f8f058461153fe2a048c4125332aaf4274e2	CD
cord-270892-ycc3csyh	4	2	doc_id	doc_id	CD
cord-270892-ycc3csyh	4	3	:	:	:
cord-270892-ycc3csyh	4	4	270892	270892	CD
cord-270892-ycc3csyh	4	5	cord_uid	cord_uid	NNS
cord-270892-ycc3csyh	4	6	:	:	:
cord-270892-ycc3csyh	5	1	ycc3csyh	ycc3csyh	NNP
cord-270892-ycc3csyh	6	1	As	as	IN
cord-270892-ycc3csyh	6	2	the	the	DT
cord-270892-ycc3csyh	6	3	major	major	JJ
cord-270892-ycc3csyh	6	4	etiological	etiological	JJ
cord-270892-ycc3csyh	6	5	agent	agent	NN
cord-270892-ycc3csyh	6	6	of	of	IN
cord-270892-ycc3csyh	6	7	the	the	DT
cord-270892-ycc3csyh	6	8	common	common	JJ
cord-270892-ycc3csyh	6	9	cold	cold	JJ
cord-270892-ycc3csyh	6	10	,	,	,
cord-270892-ycc3csyh	6	11	human	human	JJ
cord-270892-ycc3csyh	6	12	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	6	13	(	(	-LRB-
cord-270892-ycc3csyh	6	14	HRV	HRV	NNP
cord-270892-ycc3csyh	6	15	)	)	-RRB-
cord-270892-ycc3csyh	6	16	cause	cause	VB
cord-270892-ycc3csyh	6	17	millions	million	NNS
cord-270892-ycc3csyh	6	18	of	of	IN
cord-270892-ycc3csyh	6	19	lost	lose	VBN
cord-270892-ycc3csyh	6	20	working	working	NN
cord-270892-ycc3csyh	6	21	and	and	CC
cord-270892-ycc3csyh	6	22	school	school	NN
cord-270892-ycc3csyh	6	23	days	day	NNS
cord-270892-ycc3csyh	6	24	annually	annually	RB
cord-270892-ycc3csyh	6	25	.	.	.
cord-270892-ycc3csyh	7	1	Moreover	moreover	RB
cord-270892-ycc3csyh	7	2	,	,	,
cord-270892-ycc3csyh	7	3	clinical	clinical	JJ
cord-270892-ycc3csyh	7	4	studies	study	NNS
cord-270892-ycc3csyh	7	5	proved	prove	VBD
cord-270892-ycc3csyh	7	6	an	an	DT
cord-270892-ycc3csyh	7	7	association	association	NN
cord-270892-ycc3csyh	7	8	between	between	IN
cord-270892-ycc3csyh	7	9	harmless	harmless	JJ
cord-270892-ycc3csyh	7	10	upper	upper	JJ
cord-270892-ycc3csyh	7	11	respiratory	respiratory	JJ
cord-270892-ycc3csyh	7	12	tract	tract	NN
cord-270892-ycc3csyh	7	13	infections	infection	NNS
cord-270892-ycc3csyh	7	14	and	and	CC
cord-270892-ycc3csyh	7	15	more	more	RBR
cord-270892-ycc3csyh	7	16	severe	severe	JJ
cord-270892-ycc3csyh	7	17	diseases	disease	NNS
cord-270892-ycc3csyh	7	18	e.g.	e.g.	IN
cord-270892-ycc3csyh	7	19	sinusitis	sinusitis	NN
cord-270892-ycc3csyh	7	20	,	,	,
cord-270892-ycc3csyh	7	21	asthma	asthma	NN
cord-270892-ycc3csyh	7	22	,	,	,
cord-270892-ycc3csyh	7	23	and	and	CC
cord-270892-ycc3csyh	7	24	chronic	chronic	JJ
cord-270892-ycc3csyh	7	25	obstructive	obstructive	JJ
cord-270892-ycc3csyh	7	26	pulmonary	pulmonary	JJ
cord-270892-ycc3csyh	7	27	disease	disease	NN
cord-270892-ycc3csyh	7	28	.	.	.
cord-270892-ycc3csyh	8	1	Both	both	DT
cord-270892-ycc3csyh	8	2	the	the	DT
cord-270892-ycc3csyh	8	3	medicinal	medicinal	JJ
cord-270892-ycc3csyh	8	4	and	and	CC
cord-270892-ycc3csyh	8	5	socio‐economic	socio‐economic	JJ
cord-270892-ycc3csyh	8	6	impact	impact	NN
cord-270892-ycc3csyh	8	7	of	of	IN
cord-270892-ycc3csyh	8	8	HRV	HRV	NNP
cord-270892-ycc3csyh	8	9	infections	infection	NNS
cord-270892-ycc3csyh	8	10	and	and	CC
cord-270892-ycc3csyh	8	11	the	the	DT
cord-270892-ycc3csyh	8	12	lack	lack	NN
cord-270892-ycc3csyh	8	13	of	of	IN
cord-270892-ycc3csyh	8	14	antiviral	antiviral	JJ
cord-270892-ycc3csyh	8	15	drugs	drug	NNS
cord-270892-ycc3csyh	8	16	substantiate	substantiate	VBP
cord-270892-ycc3csyh	8	17	the	the	DT
cord-270892-ycc3csyh	8	18	need	need	NN
cord-270892-ycc3csyh	8	19	for	for	IN
cord-270892-ycc3csyh	8	20	intensive	intensive	JJ
cord-270892-ycc3csyh	8	21	antiviral	antiviral	JJ
cord-270892-ycc3csyh	8	22	research	research	NN
cord-270892-ycc3csyh	8	23	.	.	.
cord-270892-ycc3csyh	9	1	A	a	DT
cord-270892-ycc3csyh	9	2	common	common	JJ
cord-270892-ycc3csyh	9	3	structural	structural	JJ
cord-270892-ycc3csyh	9	4	feature	feature	NN
cord-270892-ycc3csyh	9	5	of	of	IN
cord-270892-ycc3csyh	9	6	the	the	DT
cord-270892-ycc3csyh	9	7	approximately	approximately	RB
cord-270892-ycc3csyh	9	8	100	100	CD
cord-270892-ycc3csyh	9	9	HRV	HRV	NNP
cord-270892-ycc3csyh	9	10	serotypes	serotype	NNS
cord-270892-ycc3csyh	9	11	is	be	VBZ
cord-270892-ycc3csyh	9	12	the	the	DT
cord-270892-ycc3csyh	9	13	icosahedrally	icosahedrally	RB
cord-270892-ycc3csyh	9	14	shaped	shape	VBN
cord-270892-ycc3csyh	9	15	capsid	capsid	NN
cord-270892-ycc3csyh	9	16	formed	form	VBN
cord-270892-ycc3csyh	9	17	by	by	IN
cord-270892-ycc3csyh	9	18	60	60	CD
cord-270892-ycc3csyh	9	19	identical	identical	JJ
cord-270892-ycc3csyh	9	20	copies	copy	NNS
cord-270892-ycc3csyh	9	21	of	of	IN
cord-270892-ycc3csyh	9	22	viral	viral	JJ
cord-270892-ycc3csyh	9	23	capsid	capsid	NN
cord-270892-ycc3csyh	9	24	proteins	protein	NNS
cord-270892-ycc3csyh	9	25	VP1‐4	VP1‐4	VBG
cord-270892-ycc3csyh	9	26	.	.	.
cord-270892-ycc3csyh	10	1	The	the	DT
cord-270892-ycc3csyh	10	2	capsid	capsid	NN
cord-270892-ycc3csyh	10	3	protects	protect	VBZ
cord-270892-ycc3csyh	10	4	the	the	DT
cord-270892-ycc3csyh	10	5	single‐stranded	single‐stranded	JJ
cord-270892-ycc3csyh	10	6	,	,	,
cord-270892-ycc3csyh	10	7	positive	positive	JJ
cord-270892-ycc3csyh	10	8	sense	sense	NN
cord-270892-ycc3csyh	11	1	RNA	RNA	NNP
cord-270892-ycc3csyh	11	2	genome	genome	NN
cord-270892-ycc3csyh	11	3	of	of	IN
cord-270892-ycc3csyh	11	4	about	about	RB
cord-270892-ycc3csyh	11	5	7,400	7,400	CD
cord-270892-ycc3csyh	11	6	bases	basis	NNS
cord-270892-ycc3csyh	11	7	in	in	IN
cord-270892-ycc3csyh	11	8	length	length	NN
cord-270892-ycc3csyh	11	9	.	.	.
cord-270892-ycc3csyh	12	1	Both	both	DT
cord-270892-ycc3csyh	12	2	structural	structural	JJ
cord-270892-ycc3csyh	12	3	as	as	RB
cord-270892-ycc3csyh	12	4	well	well	RB
cord-270892-ycc3csyh	12	5	as	as	IN
cord-270892-ycc3csyh	12	6	nonstructural	nonstructural	JJ
cord-270892-ycc3csyh	12	7	proteins	protein	NNS
cord-270892-ycc3csyh	12	8	produced	produce	VBN
cord-270892-ycc3csyh	12	9	during	during	IN
cord-270892-ycc3csyh	12	10	the	the	DT
cord-270892-ycc3csyh	12	11	viral	viral	JJ
cord-270892-ycc3csyh	12	12	life	life	NN
cord-270892-ycc3csyh	12	13	cycle	cycle	NN
cord-270892-ycc3csyh	12	14	have	have	VBP
cord-270892-ycc3csyh	12	15	been	be	VBN
cord-270892-ycc3csyh	12	16	identified	identify	VBN
cord-270892-ycc3csyh	12	17	as	as	IN
cord-270892-ycc3csyh	12	18	potential	potential	JJ
cord-270892-ycc3csyh	12	19	targets	target	NNS
cord-270892-ycc3csyh	12	20	for	for	IN
cord-270892-ycc3csyh	12	21	blocking	block	VBG
cord-270892-ycc3csyh	12	22	viral	viral	JJ
cord-270892-ycc3csyh	12	23	replication	replication	NN
cord-270892-ycc3csyh	12	24	at	at	IN
cord-270892-ycc3csyh	12	25	the	the	DT
cord-270892-ycc3csyh	12	26	step	step	NN
cord-270892-ycc3csyh	12	27	of	of	IN
cord-270892-ycc3csyh	12	28	attachment	attachment	NN
cord-270892-ycc3csyh	12	29	,	,	,
cord-270892-ycc3csyh	12	30	entry	entry	NN
cord-270892-ycc3csyh	12	31	,	,	,
cord-270892-ycc3csyh	12	32	uncoating	uncoating	NN
cord-270892-ycc3csyh	12	33	,	,	,
cord-270892-ycc3csyh	12	34	RNA	RNA	NNP
cord-270892-ycc3csyh	12	35	and	and	CC
cord-270892-ycc3csyh	12	36	protein	protein	NN
cord-270892-ycc3csyh	12	37	synthesis	synthesis	NN
cord-270892-ycc3csyh	12	38	by	by	IN
cord-270892-ycc3csyh	12	39	synthetic	synthetic	JJ
cord-270892-ycc3csyh	12	40	or	or	CC
cord-270892-ycc3csyh	12	41	natural	natural	JJ
cord-270892-ycc3csyh	12	42	compounds	compound	NNS
cord-270892-ycc3csyh	12	43	.	.	.
cord-270892-ycc3csyh	13	1	Moreover	moreover	RB
cord-270892-ycc3csyh	13	2	,	,	,
cord-270892-ycc3csyh	13	3	interferon	interferon	NN
cord-270892-ycc3csyh	13	4	and	and	CC
cord-270892-ycc3csyh	13	5	phytoceuticals	phytoceutical	NNS
cord-270892-ycc3csyh	13	6	were	be	VBD
cord-270892-ycc3csyh	13	7	shown	show	VBN
cord-270892-ycc3csyh	13	8	to	to	TO
cord-270892-ycc3csyh	13	9	protect	protect	VB
cord-270892-ycc3csyh	13	10	host	host	NN
cord-270892-ycc3csyh	13	11	cells	cell	NNS
cord-270892-ycc3csyh	13	12	.	.	.
cord-270892-ycc3csyh	14	1	Most	Most	JJS
cord-270892-ycc3csyh	14	2	of	of	IN
cord-270892-ycc3csyh	14	3	the	the	DT
cord-270892-ycc3csyh	14	4	known	know	VBN
cord-270892-ycc3csyh	14	5	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	14	6	of	of	IN
cord-270892-ycc3csyh	14	7	HRV	HRV	NNP
cord-270892-ycc3csyh	14	8	replication	replication	NN
cord-270892-ycc3csyh	14	9	were	be	VBD
cord-270892-ycc3csyh	14	10	discovered	discover	VBN
cord-270892-ycc3csyh	14	11	as	as	IN
cord-270892-ycc3csyh	14	12	a	a	DT
cord-270892-ycc3csyh	14	13	result	result	NN
cord-270892-ycc3csyh	14	14	of	of	IN
cord-270892-ycc3csyh	14	15	empirical	empirical	JJ
cord-270892-ycc3csyh	14	16	or	or	CC
cord-270892-ycc3csyh	14	17	semi‐empirical	semi‐empirical	JJ
cord-270892-ycc3csyh	14	18	screening	screening	NN
cord-270892-ycc3csyh	14	19	in	in	IN
cord-270892-ycc3csyh	14	20	cell	cell	NN
cord-270892-ycc3csyh	14	21	culture	culture	NN
cord-270892-ycc3csyh	14	22	.	.	.
cord-270892-ycc3csyh	15	1	Structure	structure	NN
cord-270892-ycc3csyh	15	2	–	–	:
cord-270892-ycc3csyh	15	3	activity	activity	NN
cord-270892-ycc3csyh	15	4	relationship	relationship	NN
cord-270892-ycc3csyh	15	5	studies	study	NNS
cord-270892-ycc3csyh	15	6	are	be	VBP
cord-270892-ycc3csyh	15	7	used	use	VBN
cord-270892-ycc3csyh	15	8	for	for	IN
cord-270892-ycc3csyh	15	9	hit	hit	NN
cord-270892-ycc3csyh	15	10	optimization	optimization	NN
cord-270892-ycc3csyh	15	11	and	and	CC
cord-270892-ycc3csyh	15	12	lead	lead	NN
cord-270892-ycc3csyh	15	13	structure	structure	NN
cord-270892-ycc3csyh	15	14	discovery	discovery	NN
cord-270892-ycc3csyh	15	15	.	.	.
cord-270892-ycc3csyh	16	1	The	the	DT
cord-270892-ycc3csyh	16	2	increasing	increase	VBG
cord-270892-ycc3csyh	16	3	structural	structural	JJ
cord-270892-ycc3csyh	16	4	insight	insight	NN
cord-270892-ycc3csyh	16	5	and	and	CC
cord-270892-ycc3csyh	16	6	molecular	molecular	JJ
cord-270892-ycc3csyh	16	7	understanding	understanding	NN
cord-270892-ycc3csyh	16	8	of	of	IN
cord-270892-ycc3csyh	16	9	viral	viral	JJ
cord-270892-ycc3csyh	16	10	proteins	protein	NNS
cord-270892-ycc3csyh	16	11	on	on	IN
cord-270892-ycc3csyh	16	12	the	the	DT
cord-270892-ycc3csyh	16	13	one	one	CD
cord-270892-ycc3csyh	16	14	hand	hand	NN
cord-270892-ycc3csyh	16	15	and	and	CC
cord-270892-ycc3csyh	16	16	the	the	DT
cord-270892-ycc3csyh	16	17	advent	advent	NN
cord-270892-ycc3csyh	16	18	of	of	IN
cord-270892-ycc3csyh	16	19	innovative	innovative	JJ
cord-270892-ycc3csyh	16	20	computer‐assisted	computer‐assisted	JJ
cord-270892-ycc3csyh	16	21	technologies	technology	NNS
cord-270892-ycc3csyh	16	22	on	on	IN
cord-270892-ycc3csyh	16	23	the	the	DT
cord-270892-ycc3csyh	16	24	other	other	JJ
cord-270892-ycc3csyh	16	25	hand	hand	NN
cord-270892-ycc3csyh	16	26	have	have	VBP
cord-270892-ycc3csyh	16	27	facilitated	facilitate	VBN
cord-270892-ycc3csyh	16	28	a	a	DT
cord-270892-ycc3csyh	16	29	rationalized	rationalize	VBN
cord-270892-ycc3csyh	16	30	access	access	NN
cord-270892-ycc3csyh	16	31	for	for	IN
cord-270892-ycc3csyh	16	32	the	the	DT
cord-270892-ycc3csyh	16	33	discovery	discovery	NN
cord-270892-ycc3csyh	16	34	of	of	IN
cord-270892-ycc3csyh	16	35	small	small	JJ
cord-270892-ycc3csyh	16	36	chemical	chemical	JJ
cord-270892-ycc3csyh	16	37	entities	entity	NNS
cord-270892-ycc3csyh	16	38	with	with	IN
cord-270892-ycc3csyh	16	39	antirhinoviral	antirhinoviral	NNP
cord-270892-ycc3csyh	16	40	(	(	-LRB-
cord-270892-ycc3csyh	16	41	anti‐HRV	anti‐hrv	RB
cord-270892-ycc3csyh	16	42	)	)	-RRB-
cord-270892-ycc3csyh	16	43	activity	activity	NN
cord-270892-ycc3csyh	16	44	.	.	.
cord-270892-ycc3csyh	17	1	This	this	DT
cord-270892-ycc3csyh	17	2	review	review	NN
cord-270892-ycc3csyh	17	3	will	will	MD
cord-270892-ycc3csyh	17	4	(	(	-LRB-
cord-270892-ycc3csyh	17	5	i	i	NN
cord-270892-ycc3csyh	17	6	)	)	-RRB-
cord-270892-ycc3csyh	17	7	summarize	summarize	VB
cord-270892-ycc3csyh	17	8	existing	exist	VBG
cord-270892-ycc3csyh	17	9	structural	structural	JJ
cord-270892-ycc3csyh	17	10	knowledge	knowledge	NN
cord-270892-ycc3csyh	17	11	about	about	IN
cord-270892-ycc3csyh	17	12	HRV	HRV	NNP
cord-270892-ycc3csyh	17	13	,	,	,
cord-270892-ycc3csyh	17	14	(	(	-LRB-
cord-270892-ycc3csyh	17	15	ii	ii	NN
cord-270892-ycc3csyh	17	16	)	)	-RRB-
cord-270892-ycc3csyh	17	17	focus	focus	NN
cord-270892-ycc3csyh	17	18	on	on	IN
cord-270892-ycc3csyh	17	19	mechanisms	mechanism	NNS
cord-270892-ycc3csyh	17	20	of	of	IN
cord-270892-ycc3csyh	17	21	anti‐HRV	anti‐hrv	JJ
cord-270892-ycc3csyh	17	22	agents	agent	NNS
cord-270892-ycc3csyh	17	23	from	from	IN
cord-270892-ycc3csyh	17	24	synthetic	synthetic	JJ
cord-270892-ycc3csyh	17	25	and	and	CC
cord-270892-ycc3csyh	17	26	natural	natural	JJ
cord-270892-ycc3csyh	17	27	origin	origin	NN
cord-270892-ycc3csyh	17	28	,	,	,
cord-270892-ycc3csyh	17	29	and	and	CC
cord-270892-ycc3csyh	17	30	(	(	-LRB-
cord-270892-ycc3csyh	17	31	iii	iii	NN
cord-270892-ycc3csyh	17	32	)	)	-RRB-
cord-270892-ycc3csyh	17	33	demonstrate	demonstrate	VBP
cord-270892-ycc3csyh	17	34	strategies	strategy	NNS
cord-270892-ycc3csyh	17	35	for	for	IN
cord-270892-ycc3csyh	17	36	efficient	efficient	JJ
cord-270892-ycc3csyh	17	37	lead	lead	JJ
cord-270892-ycc3csyh	17	38	structure	structure	NN
cord-270892-ycc3csyh	17	39	discovery	discovery	NN
cord-270892-ycc3csyh	17	40	.	.	.
cord-270892-ycc3csyh	18	1	©	©	NNP
cord-270892-ycc3csyh	18	2	2009	2009	CD
cord-270892-ycc3csyh	19	1	Wiley	Wiley	NNP
cord-270892-ycc3csyh	19	2	Periodicals	Periodicals	NNPS
cord-270892-ycc3csyh	19	3	,	,	,
cord-270892-ycc3csyh	20	1	Inc.	Inc.	NNP
cord-270892-ycc3csyh	20	2	Med	Med	NNP
cord-270892-ycc3csyh	20	3	Res	Res	NNP
cord-270892-ycc3csyh	20	4	Rev	Rev	NNP
cord-270892-ycc3csyh	20	5	,	,	,
cord-270892-ycc3csyh	20	6	31	31	CD
cord-270892-ycc3csyh	20	7	,	,	,
cord-270892-ycc3csyh	20	8	No	no	NN
cord-270892-ycc3csyh	20	9	.	.	NN
cord-270892-ycc3csyh	20	10	1	1	CD
cord-270892-ycc3csyh	20	11	,	,	,
cord-270892-ycc3csyh	20	12	42–92	42–92	CD
cord-270892-ycc3csyh	20	13	,	,	,
cord-270892-ycc3csyh	20	14	2010	2010	CD
cord-270892-ycc3csyh	20	15	Human	human	JJ
cord-270892-ycc3csyh	20	16	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	20	17	(	(	-LRB-
cord-270892-ycc3csyh	20	18	HRV	HRV	NNP
cord-270892-ycc3csyh	20	19	)	)	-RRB-
cord-270892-ycc3csyh	20	20	are	be	VBP
cord-270892-ycc3csyh	20	21	the	the	DT
cord-270892-ycc3csyh	20	22	major	major	JJ
cord-270892-ycc3csyh	20	23	cause	cause	NN
cord-270892-ycc3csyh	20	24	of	of	IN
cord-270892-ycc3csyh	20	25	upper	upper	JJ
cord-270892-ycc3csyh	20	26	respiratory	respiratory	JJ
cord-270892-ycc3csyh	20	27	tract	tract	NN
cord-270892-ycc3csyh	20	28	symptoms	symptom	NNS
cord-270892-ycc3csyh	20	29	,	,	,
cord-270892-ycc3csyh	20	30	the	the	DT
cord-270892-ycc3csyh	20	31	socalled	socalled	JJ
cord-270892-ycc3csyh	20	32	common	common	JJ
cord-270892-ycc3csyh	20	33	colds	cold	NNS
cord-270892-ycc3csyh	20	34	in	in	IN
cord-270892-ycc3csyh	20	35	humans	human	NNS
cord-270892-ycc3csyh	20	36	.	.	.
cord-270892-ycc3csyh	21	1	Their	-PRON-	PRP$
cord-270892-ycc3csyh	21	2	name	name	NN
cord-270892-ycc3csyh	21	3	reflects	reflect	VBZ
cord-270892-ycc3csyh	21	4	the	the	DT
cord-270892-ycc3csyh	21	5	primary	primary	JJ
cord-270892-ycc3csyh	21	6	site	site	NN
cord-270892-ycc3csyh	21	7	of	of	IN
cord-270892-ycc3csyh	21	8	infection	infection	NN
cord-270892-ycc3csyh	21	9	.	.	.
cord-270892-ycc3csyh	22	1	Because	because	IN
cord-270892-ycc3csyh	22	2	HRV	HRV	NNP
cord-270892-ycc3csyh	22	3	are	be	VBP
cord-270892-ycc3csyh	22	4	nonenveloped	nonenveloped	JJ
cord-270892-ycc3csyh	22	5	,	,	,
cord-270892-ycc3csyh	22	6	icosahedral	icosahedral	JJ
cord-270892-ycc3csyh	22	7	viruses	virus	NNS
cord-270892-ycc3csyh	22	8	of	of	IN
cord-270892-ycc3csyh	22	9	small	small	JJ
cord-270892-ycc3csyh	22	10	size	size	NN
cord-270892-ycc3csyh	22	11	with	with	IN
cord-270892-ycc3csyh	22	12	a	a	DT
cord-270892-ycc3csyh	22	13	diameter	diameter	NN
cord-270892-ycc3csyh	22	14	of	of	IN
cord-270892-ycc3csyh	22	15	about	about	RB
cord-270892-ycc3csyh	22	16	30	30	CD
cord-270892-ycc3csyh	22	17	nm	nm	NN
cord-270892-ycc3csyh	22	18	(	(	-LRB-
cord-270892-ycc3csyh	22	19	pico	pico	NN
cord-270892-ycc3csyh	22	20	5	5	CD
cord-270892-ycc3csyh	22	21	small	small	JJ
cord-270892-ycc3csyh	22	22	in	in	IN
cord-270892-ycc3csyh	22	23	Latin	Latin	NNP
cord-270892-ycc3csyh	22	24	)	)	-RRB-
cord-270892-ycc3csyh	22	25	that	that	WDT
cord-270892-ycc3csyh	22	26	consist	consist	VBP
cord-270892-ycc3csyh	22	27	of	of	IN
cord-270892-ycc3csyh	22	28	an	an	DT
cord-270892-ycc3csyh	22	29	RNA	RNA	NNP
cord-270892-ycc3csyh	22	30	genome	genome	NN
cord-270892-ycc3csyh	22	31	,	,	,
cord-270892-ycc3csyh	22	32	they	-PRON-	PRP
cord-270892-ycc3csyh	22	33	were	be	VBD
cord-270892-ycc3csyh	22	34	assigned	assign	VBN
cord-270892-ycc3csyh	22	35	to	to	IN
cord-270892-ycc3csyh	22	36	the	the	DT
cord-270892-ycc3csyh	22	37	family	family	NN
cord-270892-ycc3csyh	22	38	picornaviridae	picornaviridae	NN
cord-270892-ycc3csyh	22	39	.	.	.
cord-270892-ycc3csyh	23	1	Currently	currently	RB
cord-270892-ycc3csyh	23	2	,	,	,
cord-270892-ycc3csyh	23	3	this	this	DT
cord-270892-ycc3csyh	23	4	virus	virus	NN
cord-270892-ycc3csyh	23	5	family	family	NN
cord-270892-ycc3csyh	23	6	of	of	IN
cord-270892-ycc3csyh	23	7	the	the	DT
cord-270892-ycc3csyh	23	8	order	order	NN
cord-270892-ycc3csyh	23	9	picornavirales	picornavirales	NNP
cord-270892-ycc3csyh	23	10	comprises	comprise	VBZ
cord-270892-ycc3csyh	23	11	the	the	DT
cord-270892-ycc3csyh	23	12	eight	eight	CD
cord-270892-ycc3csyh	23	13	genera	genera	NNP
cord-270892-ycc3csyh	23	14	enterovirus	enterovirus	NN
cord-270892-ycc3csyh	23	15	,	,	,
cord-270892-ycc3csyh	23	16	hepatovirus	hepatovirus	NNP
cord-270892-ycc3csyh	23	17	,	,	,
cord-270892-ycc3csyh	23	18	cardiovirus	cardiovirus	NNP
cord-270892-ycc3csyh	23	19	,	,	,
cord-270892-ycc3csyh	23	20	kobuvirus	kobuvirus	NNP
cord-270892-ycc3csyh	23	21	,	,	,
cord-270892-ycc3csyh	23	22	teschovirus	teschovirus	NNP
cord-270892-ycc3csyh	23	23	,	,	,
cord-270892-ycc3csyh	23	24	erbovirus	erbovirus	NNP
cord-270892-ycc3csyh	23	25	,	,	,
cord-270892-ycc3csyh	23	26	aphthovirus	aphthovirus	NNP
cord-270892-ycc3csyh	23	27	,	,	,
cord-270892-ycc3csyh	23	28	and	and	CC
cord-270892-ycc3csyh	23	29	parechovirus	parechovirus	NNP
cord-270892-ycc3csyh	23	30	with	with	IN
cord-270892-ycc3csyh	23	31	22	22	CD
cord-270892-ycc3csyh	23	32	species	specie	NNS
cord-270892-ycc3csyh	23	33	and	and	CC
cord-270892-ycc3csyh	23	34	a	a	DT
cord-270892-ycc3csyh	23	35	multitude	multitude	NN
cord-270892-ycc3csyh	23	36	of	of	IN
cord-270892-ycc3csyh	23	37	serotypes	serotype	NNS
cord-270892-ycc3csyh	23	38	.	.	.
cord-270892-ycc3csyh	24	1	1	1	LS
cord-270892-ycc3csyh	25	1	Because	because	IN
cord-270892-ycc3csyh	25	2	of	of	IN
cord-270892-ycc3csyh	25	3	high	high	JJ
cord-270892-ycc3csyh	25	4	similarity	similarity	NN
cord-270892-ycc3csyh	25	5	in	in	IN
cord-270892-ycc3csyh	25	6	genome	genome	NN
cord-270892-ycc3csyh	25	7	sequence	sequence	NN
cord-270892-ycc3csyh	25	8	and	and	CC
cord-270892-ycc3csyh	25	9	genome	genome	NN
cord-270892-ycc3csyh	25	10	organization	organization	NN
cord-270892-ycc3csyh	25	11	(	(	-LRB-
cord-270892-ycc3csyh	25	12	Fig	Fig	NNP
cord-270892-ycc3csyh	25	13	.	.	NNP
cord-270892-ycc3csyh	25	14	1	1	CD
cord-270892-ycc3csyh	25	15	)	)	-RRB-
cord-270892-ycc3csyh	25	16	,	,	,
cord-270892-ycc3csyh	25	17	the	the	DT
cord-270892-ycc3csyh	25	18	former	former	JJ
cord-270892-ycc3csyh	25	19	genera	genera	CD
cord-270892-ycc3csyh	25	20	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	25	21	and	and	CC
cord-270892-ycc3csyh	25	22	enterovirus	enterovirus	NN
cord-270892-ycc3csyh	25	23	have	have	VBP
cord-270892-ycc3csyh	25	24	been	be	VBN
cord-270892-ycc3csyh	25	25	combined	combine	VBN
cord-270892-ycc3csyh	25	26	recently	recently	RB
cord-270892-ycc3csyh	25	27	,	,	,
cord-270892-ycc3csyh	25	28	keeping	keep	VBG
cord-270892-ycc3csyh	25	29	the	the	DT
cord-270892-ycc3csyh	25	30	existing	exist	VBG
cord-270892-ycc3csyh	25	31	name	name	NN
cord-270892-ycc3csyh	25	32	enterovirus	enterovirus	NN
cord-270892-ycc3csyh	25	33	(	(	-LRB-
cord-270892-ycc3csyh	25	34	www.picornastudygroup	www.picornastudygroup	NNP
cord-270892-ycc3csyh	25	35	.	.	.
cord-270892-ycc3csyh	25	36	com	com	NN
cord-270892-ycc3csyh	25	37	/	/	SYM
cord-270892-ycc3csyh	25	38	taxa	taxon	NNS
cord-270892-ycc3csyh	25	39	/	/	SYM
cord-270892-ycc3csyh	25	40	species	specie	NNS
cord-270892-ycc3csyh	25	41	/	/	SYM
cord-270892-ycc3csyh	25	42	species.htm	species.htm	CD
cord-270892-ycc3csyh	25	43	)	)	-RRB-
cord-270892-ycc3csyh	25	44	.	.	.
cord-270892-ycc3csyh	26	1	An	an	DT
cord-270892-ycc3csyh	26	2	overview	overview	NN
cord-270892-ycc3csyh	26	3	on	on	IN
cord-270892-ycc3csyh	26	4	the	the	DT
cord-270892-ycc3csyh	26	5	current	current	JJ
cord-270892-ycc3csyh	26	6	taxonomy	taxonomy	NN
cord-270892-ycc3csyh	26	7	of	of	IN
cord-270892-ycc3csyh	26	8	picornaviruses	picornavirus	NNS
cord-270892-ycc3csyh	26	9	pathogenic	pathogenic	JJ
cord-270892-ycc3csyh	26	10	for	for	IN
cord-270892-ycc3csyh	26	11	humans	human	NNS
cord-270892-ycc3csyh	26	12	as	as	RB
cord-270892-ycc3csyh	26	13	well	well	RB
cord-270892-ycc3csyh	26	14	as	as	IN
cord-270892-ycc3csyh	26	15	on	on	IN
cord-270892-ycc3csyh	26	16	newly	newly	RB
cord-270892-ycc3csyh	26	17	proposed	propose	VBN
cord-270892-ycc3csyh	26	18	species	specie	NNS
cord-270892-ycc3csyh	26	19	of	of	IN
cord-270892-ycc3csyh	26	20	HRV	HRV	NNP
cord-270892-ycc3csyh	26	21	is	be	VBZ
cord-270892-ycc3csyh	26	22	given	give	VBN
cord-270892-ycc3csyh	26	23	in	in	IN
cord-270892-ycc3csyh	26	24	Table	Table	NNP
cord-270892-ycc3csyh	26	25	I	-PRON-	PRP
cord-270892-ycc3csyh	26	26	.	.	.
cord-270892-ycc3csyh	27	1	At	at	IN
cord-270892-ycc3csyh	27	2	present	present	JJ
cord-270892-ycc3csyh	27	3	the	the	DT
cord-270892-ycc3csyh	27	4	genus	genus	NN
cord-270892-ycc3csyh	27	5	enterovirus	enterovirus	NN
cord-270892-ycc3csyh	27	6	includes	include	VBZ
cord-270892-ycc3csyh	27	7	four	four	CD
cord-270892-ycc3csyh	27	8	approved	approve	VBN
cord-270892-ycc3csyh	27	9	human	human	JJ
cord-270892-ycc3csyh	27	10	enterovirus	enterovirus	NN
cord-270892-ycc3csyh	27	11	(	(	-LRB-
cord-270892-ycc3csyh	27	12	HEV	HEV	NNP
cord-270892-ycc3csyh	27	13	)	)	-RRB-
cord-270892-ycc3csyh	27	14	species	species	NN
cord-270892-ycc3csyh	27	15	(	(	-LRB-
cord-270892-ycc3csyh	27	16	HEV	HEV	NNP
cord-270892-ycc3csyh	27	17	-	-	HYPH
cord-270892-ycc3csyh	27	18	A	a	NN
cord-270892-ycc3csyh	27	19	,	,	,
cord-270892-ycc3csyh	27	20	-B	-b	ADD
cord-270892-ycc3csyh	27	21	,	,	,
cord-270892-ycc3csyh	27	22	-C	-C	NNS
cord-270892-ycc3csyh	27	23	,	,	,
cord-270892-ycc3csyh	27	24	and	and	CC
cord-270892-ycc3csyh	27	25	-D	-D	JJS
cord-270892-ycc3csyh	27	26	)	)	-RRB-
cord-270892-ycc3csyh	27	27	and	and	CC
cord-270892-ycc3csyh	27	28	two	two	CD
cord-270892-ycc3csyh	27	29	approved	approve	VBN
cord-270892-ycc3csyh	27	30	HRV	HRV	NNP
cord-270892-ycc3csyh	27	31	species	specie	NNS
cord-270892-ycc3csyh	27	32	(	(	-LRB-
cord-270892-ycc3csyh	27	33	HRV	HRV	NNP
cord-270892-ycc3csyh	27	34	-	-	HYPH
cord-270892-ycc3csyh	27	35	A	A	NNP
cord-270892-ycc3csyh	27	36	and	and	CC
cord-270892-ycc3csyh	27	37	-B	-b	ADD
cord-270892-ycc3csyh	27	38	)	)	-RRB-
cord-270892-ycc3csyh	27	39	(	(	-LRB-
cord-270892-ycc3csyh	27	40	www	www	NNP
cord-270892-ycc3csyh	27	41	.	.	.
cord-270892-ycc3csyh	27	42	picornastudygroup.com/taxa/species/-species.htm	picornastudygroup.com/taxa/species/-species.htm	NNP
cord-270892-ycc3csyh	27	43	)	)	-RRB-
cord-270892-ycc3csyh	27	44	.	.	.
cord-270892-ycc3csyh	28	1	Since	since	IN
cord-270892-ycc3csyh	28	2	2007	2007	CD
cord-270892-ycc3csyh	28	3	,	,	,
cord-270892-ycc3csyh	28	4	the	the	DT
cord-270892-ycc3csyh	28	5	global	global	JJ
cord-270892-ycc3csyh	28	6	distribution	distribution	NN
cord-270892-ycc3csyh	28	7	of	of	IN
cord-270892-ycc3csyh	28	8	highly	highly	RB
cord-270892-ycc3csyh	28	9	divergent	divergent	JJ
cord-270892-ycc3csyh	28	10	HRV	HRV	NNP
cord-270892-ycc3csyh	28	11	strains	strain	NNS
cord-270892-ycc3csyh	28	12	was	be	VBD
cord-270892-ycc3csyh	28	13	reported	report	VBN
cord-270892-ycc3csyh	28	14	.	.	.
cord-270892-ycc3csyh	29	1	[	[	-LRB-
cord-270892-ycc3csyh	29	2	2	2	LS
cord-270892-ycc3csyh	29	3	]	]	-RRB-
cord-270892-ycc3csyh	29	4	[	[	-LRB-
cord-270892-ycc3csyh	29	5	3	3	CD
cord-270892-ycc3csyh	29	6	]	]	-RRB-
cord-270892-ycc3csyh	29	7	[	[	-LRB-
cord-270892-ycc3csyh	29	8	4	4	CD
cord-270892-ycc3csyh	29	9	]	]	-RRB-
cord-270892-ycc3csyh	30	1	[	[	-LRB-
cord-270892-ycc3csyh	30	2	5	5	CD
cord-270892-ycc3csyh	30	3	]	]	-RRB-
cord-270892-ycc3csyh	31	1	Based	base	VBN
cord-270892-ycc3csyh	31	2	on	on	IN
cord-270892-ycc3csyh	31	3	the	the	DT
cord-270892-ycc3csyh	31	4	results	result	NNS
cord-270892-ycc3csyh	31	5	of	of	IN
cord-270892-ycc3csyh	31	6	sequence	sequence	NN
cord-270892-ycc3csyh	31	7	,	,	,
cord-270892-ycc3csyh	31	8	genomic	genomic	JJ
cord-270892-ycc3csyh	31	9	,	,	,
cord-270892-ycc3csyh	31	10	and	and	CC
cord-270892-ycc3csyh	31	11	phylogenetic	phylogenetic	JJ
cord-270892-ycc3csyh	31	12	analyses	analysis	NNS
cord-270892-ycc3csyh	31	13	,	,	,
cord-270892-ycc3csyh	31	14	it	-PRON-	PRP
cord-270892-ycc3csyh	31	15	was	be	VBD
cord-270892-ycc3csyh	31	16	proposed	propose	VBN
cord-270892-ycc3csyh	31	17	that	that	IN
cord-270892-ycc3csyh	31	18	these	these	DT
cord-270892-ycc3csyh	31	19	strains	strain	NNS
cord-270892-ycc3csyh	31	20	represent	represent	VBP
cord-270892-ycc3csyh	31	21	a	a	DT
cord-270892-ycc3csyh	31	22	new	new	JJ
cord-270892-ycc3csyh	31	23	HRV	HRV	NNP
cord-270892-ycc3csyh	31	24	species	specie	NNS
cord-270892-ycc3csyh	31	25	,	,	,
cord-270892-ycc3csyh	31	26	HRV	HRV	NNP
cord-270892-ycc3csyh	31	27	-	-	HYPH
cord-270892-ycc3csyh	31	28	C.	C.	NNP
cord-270892-ycc3csyh	31	29	[	[	-LRB-
cord-270892-ycc3csyh	31	30	2	2	CD
cord-270892-ycc3csyh	31	31	]	]	-RRB-
cord-270892-ycc3csyh	31	32	[	[	-LRB-
cord-270892-ycc3csyh	31	33	3	3	CD
cord-270892-ycc3csyh	31	34	]	]	-RRB-
cord-270892-ycc3csyh	31	35	[	[	-LRB-
cord-270892-ycc3csyh	31	36	4	4	CD
cord-270892-ycc3csyh	31	37	]	]	-RRB-
cord-270892-ycc3csyh	31	38	6	6	CD
cord-270892-ycc3csyh	32	1	In	in	IN
cord-270892-ycc3csyh	32	2	2009	2009	CD
cord-270892-ycc3csyh	32	3	,	,	,
cord-270892-ycc3csyh	32	4	a	a	DT
cord-270892-ycc3csyh	32	5	further	further	JJ
cord-270892-ycc3csyh	32	6	proposal	proposal	NN
cord-270892-ycc3csyh	32	7	concerning	concern	VBG
cord-270892-ycc3csyh	32	8	a	a	DT
cord-270892-ycc3csyh	32	9	new	new	JJ
cord-270892-ycc3csyh	32	10	potential	potential	JJ
cord-270892-ycc3csyh	32	11	HRV	HRV	NNP
cord-270892-ycc3csyh	32	12	-	-	HYPH
cord-270892-ycc3csyh	32	13	D	D	NNP
cord-270892-ycc3csyh	32	14	species	specie	NNS
cord-270892-ycc3csyh	32	15	was	be	VBD
cord-270892-ycc3csyh	32	16	published	publish	VBN
cord-270892-ycc3csyh	32	17	after	after	IN
cord-270892-ycc3csyh	32	18	sequencing	sequencing	NN
cord-270892-ycc3csyh	32	19	and	and	CC
cord-270892-ycc3csyh	32	20	analysis	analysis	NN
cord-270892-ycc3csyh	32	21	of	of	IN
cord-270892-ycc3csyh	32	22	all	all	DT
cord-270892-ycc3csyh	32	23	known	know	VBN
cord-270892-ycc3csyh	32	24	HRV	HRV	NNP
cord-270892-ycc3csyh	32	25	genomes	genome	NNS
cord-270892-ycc3csyh	32	26	.	.	.
cord-270892-ycc3csyh	33	1	7	7	CD
cord-270892-ycc3csyh	34	1	The	the	DT
cord-270892-ycc3csyh	34	2	approved	approve	VBN
cord-270892-ycc3csyh	34	3	and	and	CC
cord-270892-ycc3csyh	34	4	newly	newly	RB
cord-270892-ycc3csyh	34	5	proposed	propose	VBN
cord-270892-ycc3csyh	34	6	species	specie	NNS
cord-270892-ycc3csyh	34	7	of	of	IN
cord-270892-ycc3csyh	34	8	the	the	DT
cord-270892-ycc3csyh	34	9	genus	genus	NN
cord-270892-ycc3csyh	34	10	enterovirus	enterovirus	NN
cord-270892-ycc3csyh	34	11	share	share	VB
cord-270892-ycc3csyh	34	12	Z70	Z70	NNP
cord-270892-ycc3csyh	34	13	%	%	NN
cord-270892-ycc3csyh	34	14	homology	homology	NN
cord-270892-ycc3csyh	34	15	(	(	-LRB-
cord-270892-ycc3csyh	34	16	average	average	JJ
cord-270892-ycc3csyh	34	17	amino	amino	NN
cord-270892-ycc3csyh	34	18	acid	acid	NN
cord-270892-ycc3csyh	34	19	identity	identity	NN
cord-270892-ycc3csyh	34	20	)	)	-RRB-
cord-270892-ycc3csyh	34	21	in	in	IN
cord-270892-ycc3csyh	34	22	the	the	DT
cord-270892-ycc3csyh	34	23	precapsid	precapsid	JJ
cord-270892-ycc3csyh	34	24	protein	protein	NN
cord-270892-ycc3csyh	34	25	P1	P1	NNP
cord-270892-ycc3csyh	34	26	as	as	RB
cord-270892-ycc3csyh	34	27	well	well	RB
cord-270892-ycc3csyh	34	28	as	as	IN
cord-270892-ycc3csyh	34	29	in	in	IN
cord-270892-ycc3csyh	34	30	2C	2C	NNP
cord-270892-ycc3csyh	34	31	and	and	CC
cord-270892-ycc3csyh	34	32	3CD	3CD	NNP
cord-270892-ycc3csyh	34	33	.	.	.
cord-270892-ycc3csyh	35	1	3	3	LS
cord-270892-ycc3csyh	35	2	,	,	,
cord-270892-ycc3csyh	35	3	[	[	-LRB-
cord-270892-ycc3csyh	35	4	7	7	CD
cord-270892-ycc3csyh	35	5	]	]	-RRB-
cord-270892-ycc3csyh	35	6	[	[	-LRB-
cord-270892-ycc3csyh	35	7	8	8	CD
cord-270892-ycc3csyh	35	8	]	]	-RRB-
cord-270892-ycc3csyh	35	9	[	[	-LRB-
cord-270892-ycc3csyh	35	10	9	9	CD
cord-270892-ycc3csyh	35	11	]	]	-RRB-
cord-270892-ycc3csyh	35	12	[	[	-LRB-
cord-270892-ycc3csyh	35	13	10	10	CD
cord-270892-ycc3csyh	35	14	]	]	-RRB-
cord-270892-ycc3csyh	36	1	Different	different	JJ
cord-270892-ycc3csyh	36	2	antigenic	antigenic	JJ
cord-270892-ycc3csyh	36	3	properties	property	NNS
cord-270892-ycc3csyh	36	4	provide	provide	VBP
cord-270892-ycc3csyh	36	5	the	the	DT
cord-270892-ycc3csyh	36	6	basis	basis	NN
cord-270892-ycc3csyh	36	7	for	for	IN
cord-270892-ycc3csyh	36	8	a	a	DT
cord-270892-ycc3csyh	36	9	further	further	JJ
cord-270892-ycc3csyh	36	10	division	division	NN
cord-270892-ycc3csyh	36	11	of	of	IN
cord-270892-ycc3csyh	36	12	species	specie	NNS
cord-270892-ycc3csyh	36	13	into	into	IN
cord-270892-ycc3csyh	36	14	serotypes	serotype	NNS
cord-270892-ycc3csyh	36	15	(	(	-LRB-
cord-270892-ycc3csyh	36	16	Table	table	NN
cord-270892-ycc3csyh	36	17	I	i	CD
cord-270892-ycc3csyh	36	18	)	)	-RRB-
cord-270892-ycc3csyh	36	19	.	.	.
cord-270892-ycc3csyh	37	1	About	about	RB
cord-270892-ycc3csyh	37	2	100	100	CD
cord-270892-ycc3csyh	37	3	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	37	4	serotypes	serotype	NNS
cord-270892-ycc3csyh	37	5	are	be	VBP
cord-270892-ycc3csyh	37	6	currently	currently	RB
cord-270892-ycc3csyh	37	7	known	know	VBN
cord-270892-ycc3csyh	37	8	.	.	.
cord-270892-ycc3csyh	38	1	According	accord	VBG
cord-270892-ycc3csyh	38	2	to	to	IN
cord-270892-ycc3csyh	38	3	the	the	DT
cord-270892-ycc3csyh	38	4	currently	currently	RB
cord-270892-ycc3csyh	38	5	approved	approve	VBN
cord-270892-ycc3csyh	38	6	taxonomy	taxonomy	NN
cord-270892-ycc3csyh	38	7	,	,	,
cord-270892-ycc3csyh	38	8	most	most	JJS
cord-270892-ycc3csyh	38	9	of	of	IN
cord-270892-ycc3csyh	38	10	them	-PRON-	PRP
cord-270892-ycc3csyh	38	11	(	(	-LRB-
cord-270892-ycc3csyh	38	12	75	75	CD
cord-270892-ycc3csyh	38	13	and	and	CC
cord-270892-ycc3csyh	38	14	HRV	HRV	NNP
cord-270892-ycc3csyh	38	15	Hanks	Hanks	NNP
cord-270892-ycc3csyh	38	16	)	)	-RRB-
cord-270892-ycc3csyh	38	17	belong	belong	VBP
cord-270892-ycc3csyh	38	18	to	to	IN
cord-270892-ycc3csyh	38	19	HRV	HRV	NNP
cord-270892-ycc3csyh	38	20	-	-	HYPH
cord-270892-ycc3csyh	38	21	A	A	NNP
cord-270892-ycc3csyh	38	22	and	and	CC
cord-270892-ycc3csyh	38	23	25	25	CD
cord-270892-ycc3csyh	38	24	of	of	IN
cord-270892-ycc3csyh	38	25	them	-PRON-	PRP
cord-270892-ycc3csyh	38	26	to	to	IN
cord-270892-ycc3csyh	38	27	HRV	HRV	NNP
cord-270892-ycc3csyh	38	28	-	-	HYPH
cord-270892-ycc3csyh	38	29	B.	B.	NNP
cord-270892-ycc3csyh	38	30	11	11	CD
cord-270892-ycc3csyh	38	31	,	,	,
cord-270892-ycc3csyh	38	32	12	12	CD
cord-270892-ycc3csyh	39	1	The	the	DT
cord-270892-ycc3csyh	39	2	genome	genome	NN
cord-270892-ycc3csyh	39	3	of	of	IN
cord-270892-ycc3csyh	39	4	all	all	DT
cord-270892-ycc3csyh	39	5	known	know	VBN
cord-270892-ycc3csyh	39	6	HRV	HRV	NNP
cord-270892-ycc3csyh	39	7	-	-	HYPH
cord-270892-ycc3csyh	39	8	A	A	NNP
cord-270892-ycc3csyh	39	9	and	and	CC
cord-270892-ycc3csyh	39	10	-B	-B	NFP
cord-270892-ycc3csyh	39	11	serotypes	serotype	NNS
cord-270892-ycc3csyh	39	12	as	as	RB
cord-270892-ycc3csyh	39	13	well	well	RB
cord-270892-ycc3csyh	39	14	as	as	IN
cord-270892-ycc3csyh	39	15	of	of	IN
cord-270892-ycc3csyh	39	16	several	several	JJ
cord-270892-ycc3csyh	39	17	field	field	NN
cord-270892-ycc3csyh	39	18	isolates	isolate	NNS
cord-270892-ycc3csyh	39	19	of	of	IN
cord-270892-ycc3csyh	39	20	HRV	HRV	NNP
cord-270892-ycc3csyh	39	21	-	-	HYPH
cord-270892-ycc3csyh	39	22	A	A	NNP
cord-270892-ycc3csyh	39	23	,	,	,
cord-270892-ycc3csyh	39	24	-B	-b	ADD
cord-270892-ycc3csyh	39	25	,	,	,
cord-270892-ycc3csyh	39	26	and	and	CC
cord-270892-ycc3csyh	39	27	-C	-C	NNS
cord-270892-ycc3csyh	39	28	has	have	VBZ
cord-270892-ycc3csyh	39	29	been	be	VBN
cord-270892-ycc3csyh	39	30	sequenced	sequence	VBN
cord-270892-ycc3csyh	39	31	completely	completely	RB
cord-270892-ycc3csyh	39	32	.	.	.
cord-270892-ycc3csyh	40	1	3	3	CD
cord-270892-ycc3csyh	40	2	,	,	,
cord-270892-ycc3csyh	40	3	7	7	CD
cord-270892-ycc3csyh	40	4	,	,	,
cord-270892-ycc3csyh	40	5	[	[	-LRB-
cord-270892-ycc3csyh	40	6	13	13	CD
cord-270892-ycc3csyh	40	7	]	]	-RRB-
cord-270892-ycc3csyh	40	8	[	[	-LRB-
cord-270892-ycc3csyh	40	9	14	14	CD
cord-270892-ycc3csyh	40	10	]	]	-RRB-
cord-270892-ycc3csyh	40	11	[	[	-LRB-
cord-270892-ycc3csyh	40	12	15	15	CD
cord-270892-ycc3csyh	40	13	]	]	-RRB-
cord-270892-ycc3csyh	40	14	[	[	-LRB-
cord-270892-ycc3csyh	40	15	16	16	CD
cord-270892-ycc3csyh	40	16	]	]	-RRB-
cord-270892-ycc3csyh	40	17	[	[	-LRB-
cord-270892-ycc3csyh	40	18	17	17	CD
cord-270892-ycc3csyh	40	19	]	]	-RRB-
cord-270892-ycc3csyh	40	20	[	[	-LRB-
cord-270892-ycc3csyh	40	21	18	18	CD
cord-270892-ycc3csyh	40	22	]	]	-RRB-
cord-270892-ycc3csyh	40	23	[	[	-LRB-
cord-270892-ycc3csyh	40	24	19	19	CD
cord-270892-ycc3csyh	40	25	]	]	-RRB-
cord-270892-ycc3csyh	41	1	[	[	-LRB-
cord-270892-ycc3csyh	41	2	20	20	CD
cord-270892-ycc3csyh	41	3	]	]	-RRB-
cord-270892-ycc3csyh	41	4	Viruses	virus	NNS
cord-270892-ycc3csyh	41	5	classified	classify	VBN
cord-270892-ycc3csyh	41	6	as	as	IN
cord-270892-ycc3csyh	41	7	HRV	HRV	NNP
cord-270892-ycc3csyh	41	8	-	-	HYPH
cord-270892-ycc3csyh	41	9	C	C	NNP
cord-270892-ycc3csyh	41	10	could	could	MD
cord-270892-ycc3csyh	41	11	not	not	RB
cord-270892-ycc3csyh	41	12	be	be	VB
cord-270892-ycc3csyh	41	13	grown	grow	VBN
cord-270892-ycc3csyh	41	14	in	in	IN
cord-270892-ycc3csyh	41	15	cell	cell	NN
cord-270892-ycc3csyh	41	16	culture	culture	NN
cord-270892-ycc3csyh	41	17	until	until	IN
cord-270892-ycc3csyh	41	18	now	now	RB
cord-270892-ycc3csyh	41	19	.	.	.
cord-270892-ycc3csyh	42	1	Phylogenetic	phylogenetic	JJ
cord-270892-ycc3csyh	42	2	analyses	analysis	NNS
cord-270892-ycc3csyh	42	3	have	have	VBP
cord-270892-ycc3csyh	42	4	been	be	VBN
cord-270892-ycc3csyh	42	5	performed	perform	VBN
cord-270892-ycc3csyh	42	6	with	with	IN
cord-270892-ycc3csyh	42	7	partial	partial	JJ
cord-270892-ycc3csyh	42	8	sequences	sequence	NNS
cord-270892-ycc3csyh	42	9	,	,	,
cord-270892-ycc3csyh	42	10	12	12	CD
cord-270892-ycc3csyh	42	11	,	,	,
cord-270892-ycc3csyh	42	12	21	21	CD
cord-270892-ycc3csyh	42	13	as	as	RB
cord-270892-ycc3csyh	42	14	well	well	RB
cord-270892-ycc3csyh	42	15	as	as	IN
cord-270892-ycc3csyh	42	16	with	with	IN
cord-270892-ycc3csyh	42	17	the	the	DT
cord-270892-ycc3csyh	42	18	whole	whole	JJ
cord-270892-ycc3csyh	42	19	genome	genome	NN
cord-270892-ycc3csyh	42	20	.	.	.
cord-270892-ycc3csyh	43	1	3	3	CD
cord-270892-ycc3csyh	43	2	,	,	,
cord-270892-ycc3csyh	43	3	7	7	CD
cord-270892-ycc3csyh	44	1	The	the	DT
cord-270892-ycc3csyh	44	2	most	most	RBS
cord-270892-ycc3csyh	44	3	recent	recent	JJ
cord-270892-ycc3csyh	44	4	and	and	CC
cord-270892-ycc3csyh	44	5	comprehensive	comprehensive	JJ
cord-270892-ycc3csyh	44	6	analysis	analysis	NN
cord-270892-ycc3csyh	44	7	of	of	IN
cord-270892-ycc3csyh	44	8	all	all	DT
cord-270892-ycc3csyh	44	9	known	know	VBN
cord-270892-ycc3csyh	44	10	HRV	HRV	NNP
cord-270892-ycc3csyh	44	11	genomes	genome	NNS
cord-270892-ycc3csyh	44	12	revealed	reveal	VBD
cord-270892-ycc3csyh	44	13	that	that	IN
cord-270892-ycc3csyh	44	14	(	(	-LRB-
cord-270892-ycc3csyh	44	15	i	i	NN
cord-270892-ycc3csyh	44	16	)	)	-RRB-
cord-270892-ycc3csyh	44	17	HRV	HRV	NNP
cord-270892-ycc3csyh	44	18	-	-	HYPH
cord-270892-ycc3csyh	44	19	A	A	NNP
cord-270892-ycc3csyh	44	20	and	and	CC
cord-270892-ycc3csyh	44	21	HRV	HRV	NNP
cord-270892-ycc3csyh	44	22	-	-	HYPH
cord-270892-ycc3csyh	44	23	C	C	NNP
cord-270892-ycc3csyh	44	24	share	share	VBP
cord-270892-ycc3csyh	44	25	a	a	DT
cord-270892-ycc3csyh	44	26	common	common	JJ
cord-270892-ycc3csyh	44	27	ancestor	ancestor	NN
cord-270892-ycc3csyh	44	28	,	,	,
cord-270892-ycc3csyh	44	29	which	which	WDT
cord-270892-ycc3csyh	44	30	is	be	VBZ
cord-270892-ycc3csyh	44	31	a	a	DT
cord-270892-ycc3csyh	44	32	sister	sister	NN
cord-270892-ycc3csyh	44	33	group	group	NN
cord-270892-ycc3csyh	44	34	to	to	IN
cord-270892-ycc3csyh	44	35	HRV	HRV	NNP
cord-270892-ycc3csyh	44	36	-	-	HYPH
cord-270892-ycc3csyh	44	37	B	B	NNP
cord-270892-ycc3csyh	44	38	,	,	,
cord-270892-ycc3csyh	44	39	(	(	-LRB-
cord-270892-ycc3csyh	44	40	ii	ii	NN
cord-270892-ycc3csyh	44	41	)	)	-RRB-
cord-270892-ycc3csyh	44	42	HRV	HRV	NNP
cord-270892-ycc3csyh	44	43	-	-	HYPH
cord-270892-ycc3csyh	44	44	C	C	NNP
cord-270892-ycc3csyh	44	45	represents	represent	VBZ
cord-270892-ycc3csyh	44	46	a	a	DT
cord-270892-ycc3csyh	44	47	third	third	JJ
cord-270892-ycc3csyh	44	48	species	specie	NNS
cord-270892-ycc3csyh	44	49	,	,	,
cord-270892-ycc3csyh	44	50	and	and	CC
cord-270892-ycc3csyh	44	51	(	(	-LRB-
cord-270892-ycc3csyh	44	52	iii	iii	NN
cord-270892-ycc3csyh	44	53	)	)	-RRB-
cord-270892-ycc3csyh	45	1	a	a	DT
cord-270892-ycc3csyh	45	2	basal	basal	NN
cord-270892-ycc3csyh	45	3	divergence	divergence	NN
cord-270892-ycc3csyh	45	4	within	within	IN
cord-270892-ycc3csyh	45	5	HRV	HRV	NNP
cord-270892-ycc3csyh	46	1	-A	-A	:
cord-270892-ycc3csyh	46	2	of	of	IN
cord-270892-ycc3csyh	46	3	three	three	CD
cord-270892-ycc3csyh	46	4	distinct	distinct	JJ
cord-270892-ycc3csyh	46	5	strains	strain	NNS
cord-270892-ycc3csyh	46	6	that	that	WDT
cord-270892-ycc3csyh	46	7	led	lead	VBD
cord-270892-ycc3csyh	46	8	to	to	IN
cord-270892-ycc3csyh	46	9	the	the	DT
cord-270892-ycc3csyh	46	10	proposal	proposal	NN
cord-270892-ycc3csyh	46	11	of	of	IN
cord-270892-ycc3csyh	46	12	a	a	DT
cord-270892-ycc3csyh	46	13	fourth	fourth	JJ
cord-270892-ycc3csyh	46	14	species	species	NN
cord-270892-ycc3csyh	46	15	HRV	HRV	NNP
cord-270892-ycc3csyh	46	16	-	-	HYPH
cord-270892-ycc3csyh	46	17	D.	D.	NNP
cord-270892-ycc3csyh	46	18	HRV	HRV	NNP
cord-270892-ycc3csyh	46	19	-	-	HYPH
cord-270892-ycc3csyh	46	20	A	A	NNP
cord-270892-ycc3csyh	46	21	and	and	CC
cord-270892-ycc3csyh	46	22	-B	-B	JJR
cord-270892-ycc3csyh	46	23	most	most	RBS
cord-270892-ycc3csyh	46	24	often	often	RB
cord-270892-ycc3csyh	46	25	induce	induce	VBP
cord-270892-ycc3csyh	46	26	a	a	DT
cord-270892-ycc3csyh	46	27	mild	mild	JJ
cord-270892-ycc3csyh	46	28	,	,	,
cord-270892-ycc3csyh	46	29	usually	usually	RB
cord-270892-ycc3csyh	46	30	self	self	NN
cord-270892-ycc3csyh	46	31	-	-	HYPH
cord-270892-ycc3csyh	46	32	limited	limit	VBN
cord-270892-ycc3csyh	46	33	upper	upper	JJ
cord-270892-ycc3csyh	46	34	respiratory	respiratory	JJ
cord-270892-ycc3csyh	46	35	illness	illness	NN
cord-270892-ycc3csyh	46	36	in	in	IN
cord-270892-ycc3csyh	46	37	humans	human	NNS
cord-270892-ycc3csyh	46	38	characterized	characterize	VBN
cord-270892-ycc3csyh	46	39	by	by	IN
cord-270892-ycc3csyh	46	40	nasal	nasal	JJ
cord-270892-ycc3csyh	46	41	stuffiness	stuffiness	NN
cord-270892-ycc3csyh	46	42	and	and	CC
cord-270892-ycc3csyh	46	43	discharge	discharge	NN
cord-270892-ycc3csyh	46	44	,	,	,
cord-270892-ycc3csyh	46	45	sneezing	sneeze	VBG
cord-270892-ycc3csyh	46	46	,	,	,
cord-270892-ycc3csyh	46	47	sore	sore	JJ
cord-270892-ycc3csyh	46	48	throat	throat	NN
cord-270892-ycc3csyh	46	49	,	,	,
cord-270892-ycc3csyh	46	50	and	and	CC
cord-270892-ycc3csyh	46	51	cough	cough	NN
cord-270892-ycc3csyh	46	52	.	.	.
cord-270892-ycc3csyh	47	1	The	the	DT
cord-270892-ycc3csyh	47	2	conventional	conventional	JJ
cord-270892-ycc3csyh	47	3	term	term	NN
cord-270892-ycc3csyh	47	4	is	be	VBZ
cord-270892-ycc3csyh	47	5	common	common	JJ
cord-270892-ycc3csyh	47	6	cold	cold	NN
cord-270892-ycc3csyh	47	7	.	.	.
cord-270892-ycc3csyh	48	1	The	the	DT
cord-270892-ycc3csyh	48	2	common	common	JJ
cord-270892-ycc3csyh	48	3	cold	cold	NN
cord-270892-ycc3csyh	48	4	is	be	VBZ
cord-270892-ycc3csyh	48	5	a	a	DT
cord-270892-ycc3csyh	48	6	heterogeneous	heterogeneous	JJ
cord-270892-ycc3csyh	48	7	group	group	NN
cord-270892-ycc3csyh	48	8	of	of	IN
cord-270892-ycc3csyh	48	9	diseases	disease	NNS
cord-270892-ycc3csyh	48	10	caused	cause	VBN
cord-270892-ycc3csyh	48	11	by	by	IN
cord-270892-ycc3csyh	48	12	numerous	numerous	JJ
cord-270892-ycc3csyh	48	13	viruses	virus	NNS
cord-270892-ycc3csyh	48	14	that	that	WDT
cord-270892-ycc3csyh	48	15	belong	belong	VBP
cord-270892-ycc3csyh	48	16	to	to	IN
cord-270892-ycc3csyh	48	17	several	several	JJ
cord-270892-ycc3csyh	48	18	different	different	JJ
cord-270892-ycc3csyh	48	19	families	family	NNS
cord-270892-ycc3csyh	48	20	e.g.	e.g.	IN
cord-270892-ycc3csyh	48	21	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	48	22	,	,	,
cord-270892-ycc3csyh	48	23	coronaviruses	coronaviruse	NNS
cord-270892-ycc3csyh	48	24	,	,	,
cord-270892-ycc3csyh	48	25	enteroviruses	enteroviruses	NNP
cord-270892-ycc3csyh	48	26	,	,	,
cord-270892-ycc3csyh	48	27	and	and	CC
cord-270892-ycc3csyh	48	28	adenoviruses	adenovirus	NNS
cord-270892-ycc3csyh	48	29	.	.	.
cord-270892-ycc3csyh	49	1	22	22	CD
cord-270892-ycc3csyh	50	1	But	but	CC
cord-270892-ycc3csyh	50	2	,	,	,
cord-270892-ycc3csyh	50	3	HRV	HRV	NNP
cord-270892-ycc3csyh	50	4	represent	represent	VBP
cord-270892-ycc3csyh	50	5	the	the	DT
cord-270892-ycc3csyh	50	6	most	most	RBS
cord-270892-ycc3csyh	50	7	common	common	JJ
cord-270892-ycc3csyh	50	8	etiological	etiological	JJ
cord-270892-ycc3csyh	50	9	agent	agent	NN
cord-270892-ycc3csyh	50	10	worldwide	worldwide	RB
cord-270892-ycc3csyh	50	11	.	.	.
cord-270892-ycc3csyh	51	1	A	a	DT
cord-270892-ycc3csyh	51	2	large	large	JJ
cord-270892-ycc3csyh	51	3	number	number	NN
cord-270892-ycc3csyh	51	4	of	of	IN
cord-270892-ycc3csyh	51	5	distinct	distinct	JJ
cord-270892-ycc3csyh	51	6	strains	strain	NNS
cord-270892-ycc3csyh	51	7	circulate	circulate	VBP
cord-270892-ycc3csyh	51	8	each	each	DT
cord-270892-ycc3csyh	51	9	year	year	NN
cord-270892-ycc3csyh	51	10	.	.	.
cord-270892-ycc3csyh	52	1	23	23	CD
cord-270892-ycc3csyh	53	1	Moreover	moreover	RB
cord-270892-ycc3csyh	53	2	,	,	,
cord-270892-ycc3csyh	53	3	in	in	IN
cord-270892-ycc3csyh	53	4	a	a	DT
cord-270892-ycc3csyh	53	5	family	family	NN
cord-270892-ycc3csyh	53	6	or	or	CC
cord-270892-ycc3csyh	53	7	even	even	RB
cord-270892-ycc3csyh	53	8	in	in	IN
cord-270892-ycc3csyh	53	9	a	a	DT
cord-270892-ycc3csyh	53	10	single	single	JJ
cord-270892-ycc3csyh	53	11	specimen	specimen	NN
cord-270892-ycc3csyh	53	12	,	,	,
cord-270892-ycc3csyh	53	13	multiple	multiple	JJ
cord-270892-ycc3csyh	53	14	HRV	HRV	NNP
cord-270892-ycc3csyh	53	15	serotypes	serotype	NNS
cord-270892-ycc3csyh	53	16	were	be	VBD
cord-270892-ycc3csyh	53	17	detected	detect	VBN
cord-270892-ycc3csyh	53	18	simultaneously	simultaneously	RB
cord-270892-ycc3csyh	53	19	.	.	.
cord-270892-ycc3csyh	54	1	[	[	-LRB-
cord-270892-ycc3csyh	54	2	24	24	CD
cord-270892-ycc3csyh	54	3	]	]	-RRB-
cord-270892-ycc3csyh	54	4	[	[	-LRB-
cord-270892-ycc3csyh	54	5	25	25	CD
cord-270892-ycc3csyh	54	6	]	]	-RRB-
cord-270892-ycc3csyh	54	7	[	[	-LRB-
cord-270892-ycc3csyh	54	8	26	26	CD
cord-270892-ycc3csyh	54	9	]	]	-RRB-
cord-270892-ycc3csyh	55	1	By	by	IN
cord-270892-ycc3csyh	55	2	using	use	VBG
cord-270892-ycc3csyh	55	3	RT	RT	NNP
cord-270892-ycc3csyh	55	4	-	-	HYPH
cord-270892-ycc3csyh	55	5	PCR	PCR	NNP
cord-270892-ycc3csyh	55	6	and	and	CC
cord-270892-ycc3csyh	55	7	culture	culture	NN
cord-270892-ycc3csyh	55	8	,	,	,
cord-270892-ycc3csyh	55	9	it	-PRON-	PRP
cord-270892-ycc3csyh	55	10	was	be	VBD
cord-270892-ycc3csyh	55	11	shown	show	VBN
cord-270892-ycc3csyh	55	12	that	that	IN
cord-270892-ycc3csyh	55	13	HRV	HRV	NNP
cord-270892-ycc3csyh	55	14	induce	induce	VB
cord-270892-ycc3csyh	55	15	22	22	CD
cord-270892-ycc3csyh	55	16	-	-	SYM
cord-270892-ycc3csyh	55	17	50	50	CD
cord-270892-ycc3csyh	55	18	%	%	NN
cord-270892-ycc3csyh	55	19	of	of	IN
cord-270892-ycc3csyh	55	20	upper	upper	JJ
cord-270892-ycc3csyh	55	21	respiratory	respiratory	JJ
cord-270892-ycc3csyh	55	22	tract	tract	NN
cord-270892-ycc3csyh	55	23	infections	infection	NNS
cord-270892-ycc3csyh	55	24	in	in	IN
cord-270892-ycc3csyh	55	25	adults	adult	NNS
cord-270892-ycc3csyh	55	26	as	as	RB
cord-270892-ycc3csyh	55	27	well	well	RB
cord-270892-ycc3csyh	55	28	as	as	IN
cord-270892-ycc3csyh	55	29	children	child	NNS
cord-270892-ycc3csyh	55	30	.	.	.
cord-270892-ycc3csyh	56	1	[	[	-LRB-
cord-270892-ycc3csyh	56	2	27	27	CD
cord-270892-ycc3csyh	56	3	]	]	-RRB-
cord-270892-ycc3csyh	56	4	[	[	-LRB-
cord-270892-ycc3csyh	56	5	28	28	CD
cord-270892-ycc3csyh	56	6	]	]	-RRB-
cord-270892-ycc3csyh	57	1	[	[	-LRB-
cord-270892-ycc3csyh	57	2	29	29	CD
cord-270892-ycc3csyh	57	3	]	]	-RRB-
cord-270892-ycc3csyh	58	1	[	[	-LRB-
cord-270892-ycc3csyh	58	2	30	30	CD
cord-270892-ycc3csyh	58	3	]	]	-RRB-
cord-270892-ycc3csyh	58	4	[	[	-LRB-
cord-270892-ycc3csyh	58	5	31	31	CD
cord-270892-ycc3csyh	58	6	]	]	-RRB-
cord-270892-ycc3csyh	58	7	Higher	high	JJR
cord-270892-ycc3csyh	58	8	incidence	incidence	NN
cord-270892-ycc3csyh	58	9	has	have	VBZ
cord-270892-ycc3csyh	58	10	been	be	VBN
cord-270892-ycc3csyh	58	11	described	describe	VBN
cord-270892-ycc3csyh	58	12	from	from	IN
cord-270892-ycc3csyh	58	13	September	September	NNP
cord-270892-ycc3csyh	58	14	to	to	IN
cord-270892-ycc3csyh	58	15	November	November	NNP
cord-270892-ycc3csyh	58	16	,	,	,
cord-270892-ycc3csyh	58	17	[	[	-LRB-
cord-270892-ycc3csyh	58	18	32	32	CD
cord-270892-ycc3csyh	58	19	]	]	-RRB-
cord-270892-ycc3csyh	58	20	[	[	-LRB-
cord-270892-ycc3csyh	58	21	33	33	CD
cord-270892-ycc3csyh	58	22	]	]	-RRB-
cord-270892-ycc3csyh	58	23	[	[	-LRB-
cord-270892-ycc3csyh	58	24	34	34	CD
cord-270892-ycc3csyh	58	25	]	]	-RRB-
cord-270892-ycc3csyh	58	26	and	and	CC
cord-270892-ycc3csyh	58	27	from	from	IN
cord-270892-ycc3csyh	58	28	April	April	NNP
cord-270892-ycc3csyh	58	29	to	to	IN
cord-270892-ycc3csyh	58	30	May.	May	NNP
cord-270892-ycc3csyh	58	31	33	33	CD
cord-270892-ycc3csyh	58	32	,	,	,
cord-270892-ycc3csyh	58	33	34	34	CD
cord-270892-ycc3csyh	59	1	In	in	IN
cord-270892-ycc3csyh	59	2	some	some	DT
cord-270892-ycc3csyh	59	3	years	year	NNS
cord-270892-ycc3csyh	59	4	and	and	CC
cord-270892-ycc3csyh	59	5	perhaps	perhaps	RB
cord-270892-ycc3csyh	59	6	some	some	DT
cord-270892-ycc3csyh	59	7	geographical	geographical	JJ
cord-270892-ycc3csyh	59	8	areas	area	NNS
cord-270892-ycc3csyh	59	9	,	,	,
cord-270892-ycc3csyh	59	10	spring	spring	NN
cord-270892-ycc3csyh	59	11	was	be	VBD
cord-270892-ycc3csyh	59	12	a	a	DT
cord-270892-ycc3csyh	59	13	more	more	RBR
cord-270892-ycc3csyh	59	14	important	important	JJ
cord-270892-ycc3csyh	59	15	time	time	NN
cord-270892-ycc3csyh	59	16	for	for	IN
cord-270892-ycc3csyh	59	17	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	59	18	transmission	transmission	NN
cord-270892-ycc3csyh	59	19	.	.	.
cord-270892-ycc3csyh	60	1	33	33	CD
cord-270892-ycc3csyh	60	2	,	,	,
cord-270892-ycc3csyh	60	3	34	34	CD
cord-270892-ycc3csyh	61	1	Although	although	IN
cord-270892-ycc3csyh	61	2	overall	overall	JJ
cord-270892-ycc3csyh	61	3	rates	rate	NNS
cord-270892-ycc3csyh	61	4	of	of	IN
cord-270892-ycc3csyh	61	5	respiratory	respiratory	JJ
cord-270892-ycc3csyh	61	6	illness	illness	NN
cord-270892-ycc3csyh	61	7	are	be	VBP
cord-270892-ycc3csyh	61	8	lower	low	JJR
cord-270892-ycc3csyh	61	9	in	in	IN
cord-270892-ycc3csyh	61	10	summer	summer	NN
cord-270892-ycc3csyh	61	11	,	,	,
cord-270892-ycc3csyh	61	12	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	61	13	are	be	VBP
cord-270892-ycc3csyh	61	14	the	the	DT
cord-270892-ycc3csyh	61	15	most	most	RBS
cord-270892-ycc3csyh	61	16	frequently	frequently	RB
cord-270892-ycc3csyh	61	17	isolated	isolate	VBN
cord-270892-ycc3csyh	61	18	at	at	IN
cord-270892-ycc3csyh	61	19	this	this	DT
cord-270892-ycc3csyh	61	20	time	time	NN
cord-270892-ycc3csyh	61	21	of	of	IN
cord-270892-ycc3csyh	61	22	year	year	NN
cord-270892-ycc3csyh	61	23	.	.	.
cord-270892-ycc3csyh	62	1	34	34	CD
cord-270892-ycc3csyh	63	1	The	the	DT
cord-270892-ycc3csyh	63	2	incidence	incidence	NN
cord-270892-ycc3csyh	63	3	is	be	VBZ
cord-270892-ycc3csyh	63	4	inversely	inversely	RB
cord-270892-ycc3csyh	63	5	proportional	proportional	JJ
cord-270892-ycc3csyh	63	6	to	to	IN
cord-270892-ycc3csyh	63	7	age	age	NN
cord-270892-ycc3csyh	63	8	.	.	.
cord-270892-ycc3csyh	64	1	25	25	CD
cord-270892-ycc3csyh	64	2	,	,	,
cord-270892-ycc3csyh	64	3	35	35	CD
cord-270892-ycc3csyh	64	4	By	by	IN
cord-270892-ycc3csyh	64	5	age	age	NN
cord-270892-ycc3csyh	64	6	2	2	CD
cord-270892-ycc3csyh	64	7	years	year	NNS
cord-270892-ycc3csyh	64	8	,	,	,
cord-270892-ycc3csyh	64	9	91	91	CD
cord-270892-ycc3csyh	64	10	%	%	NN
cord-270892-ycc3csyh	64	11	of	of	IN
cord-270892-ycc3csyh	64	12	the	the	DT
cord-270892-ycc3csyh	64	13	children	child	NNS
cord-270892-ycc3csyh	64	14	have	have	VBP
cord-270892-ycc3csyh	64	15	antibodies	antibody	NNS
cord-270892-ycc3csyh	64	16	against	against	IN
cord-270892-ycc3csyh	64	17	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	64	18	.	.	.
cord-270892-ycc3csyh	65	1	36	36	CD
cord-270892-ycc3csyh	66	1	In	in	IN
cord-270892-ycc3csyh	66	2	addition	addition	NN
cord-270892-ycc3csyh	66	3	to	to	IN
cord-270892-ycc3csyh	66	4	common	common	JJ
cord-270892-ycc3csyh	66	5	cold	cold	NN
cord-270892-ycc3csyh	66	6	,	,	,
cord-270892-ycc3csyh	66	7	HRV	HRV	NNP
cord-270892-ycc3csyh	66	8	are	be	VBP
cord-270892-ycc3csyh	66	9	also	also	RB
cord-270892-ycc3csyh	66	10	involved	involve	VBN
cord-270892-ycc3csyh	66	11	in	in	IN
cord-270892-ycc3csyh	66	12	acute	acute	JJ
cord-270892-ycc3csyh	66	13	otitis	otitis	NN
cord-270892-ycc3csyh	66	14	media	medium	NNS
cord-270892-ycc3csyh	66	15	in	in	IN
cord-270892-ycc3csyh	66	16	children	child	NNS
cord-270892-ycc3csyh	66	17	.	.	.
cord-270892-ycc3csyh	67	1	36	36	CD
cord-270892-ycc3csyh	67	2	,	,	,
cord-270892-ycc3csyh	67	3	37	37	CD
cord-270892-ycc3csyh	67	4	Moreover	moreover	RB
cord-270892-ycc3csyh	67	5	,	,	,
cord-270892-ycc3csyh	67	6	data	datum	NNS
cord-270892-ycc3csyh	67	7	supporting	support	VBG
cord-270892-ycc3csyh	67	8	a	a	DT
cord-270892-ycc3csyh	67	9	causative	causative	JJ
cord-270892-ycc3csyh	67	10	association	association	NN
cord-270892-ycc3csyh	67	11	with	with	IN
cord-270892-ycc3csyh	67	12	more	more	RBR
cord-270892-ycc3csyh	67	13	severe	severe	JJ
cord-270892-ycc3csyh	67	14	lower	low	JJR
cord-270892-ycc3csyh	67	15	respiratory	respiratory	JJ
cord-270892-ycc3csyh	67	16	tract	tract	NN
cord-270892-ycc3csyh	67	17	infections	infection	NNS
cord-270892-ycc3csyh	67	18	of	of	IN
cord-270892-ycc3csyh	67	19	infants	infant	NNS
cord-270892-ycc3csyh	67	20	,	,	,
cord-270892-ycc3csyh	67	21	elderly	elderly	JJ
cord-270892-ycc3csyh	67	22	persons	person	NNS
cord-270892-ycc3csyh	67	23	,	,	,
cord-270892-ycc3csyh	67	24	and	and	CC
cord-270892-ycc3csyh	67	25	immunocompromised	immunocompromised	JJ
cord-270892-ycc3csyh	67	26	patients	patient	NNS
cord-270892-ycc3csyh	67	27	have	have	VBP
cord-270892-ycc3csyh	67	28	been	be	VBN
cord-270892-ycc3csyh	67	29	accumulated	accumulate	VBN
cord-270892-ycc3csyh	67	30	.	.	.
cord-270892-ycc3csyh	68	1	[	[	-LRB-
cord-270892-ycc3csyh	68	2	38	38	CD
cord-270892-ycc3csyh	68	3	]	]	-RRB-
cord-270892-ycc3csyh	68	4	[	[	-LRB-
cord-270892-ycc3csyh	68	5	39	39	CD
cord-270892-ycc3csyh	68	6	]	]	-RRB-
cord-270892-ycc3csyh	68	7	[	[	-LRB-
cord-270892-ycc3csyh	68	8	40	40	CD
cord-270892-ycc3csyh	68	9	]	]	-RRB-
cord-270892-ycc3csyh	68	10	[	[	-LRB-
cord-270892-ycc3csyh	68	11	41	41	CD
cord-270892-ycc3csyh	68	12	]	]	-RRB-
cord-270892-ycc3csyh	69	1	[	[	-LRB-
cord-270892-ycc3csyh	69	2	42	42	CD
cord-270892-ycc3csyh	69	3	]	]	-RRB-
cord-270892-ycc3csyh	69	4	[	[	-LRB-
cord-270892-ycc3csyh	69	5	43	43	CD
cord-270892-ycc3csyh	69	6	]	]	-RRB-
cord-270892-ycc3csyh	69	7	[	[	-LRB-
cord-270892-ycc3csyh	69	8	44	44	CD
cord-270892-ycc3csyh	69	9	]	]	-RRB-
cord-270892-ycc3csyh	70	1	[	[	-LRB-
cord-270892-ycc3csyh	70	2	45	45	CD
cord-270892-ycc3csyh	70	3	]	]	-RRB-
cord-270892-ycc3csyh	70	4	Studies	study	NNS
cord-270892-ycc3csyh	70	5	of	of	IN
cord-270892-ycc3csyh	70	6	childhood	childhood	NN
cord-270892-ycc3csyh	70	7	and	and	CC
cord-270892-ycc3csyh	70	8	adult	adult	NN
cord-270892-ycc3csyh	70	9	asthma	asthma	NNS
cord-270892-ycc3csyh	70	10	have	have	VBP
cord-270892-ycc3csyh	70	11	shown	show	VBN
cord-270892-ycc3csyh	70	12	that	that	IN
cord-270892-ycc3csyh	70	13	HRV	HRV	NNP
cord-270892-ycc3csyh	70	14	infections	infection	NNS
cord-270892-ycc3csyh	70	15	can	can	MD
cord-270892-ycc3csyh	70	16	also	also	RB
cord-270892-ycc3csyh	70	17	trigger	trigger	VB
cord-270892-ycc3csyh	70	18	exacerbations	exacerbation	NNS
cord-270892-ycc3csyh	70	19	in	in	IN
cord-270892-ycc3csyh	70	20	patients	patient	NNS
cord-270892-ycc3csyh	70	21	with	with	IN
cord-270892-ycc3csyh	70	22	asthma	asthma	NN
cord-270892-ycc3csyh	70	23	,	,	.
cord-270892-ycc3csyh	71	1	[	[	-LRB-
cord-270892-ycc3csyh	71	2	46	46	CD
cord-270892-ycc3csyh	71	3	]	]	-RRB-
cord-270892-ycc3csyh	71	4	[	[	-LRB-
cord-270892-ycc3csyh	71	5	47	47	CD
cord-270892-ycc3csyh	71	6	]	]	-RRB-
cord-270892-ycc3csyh	72	1	[	[	-LRB-
cord-270892-ycc3csyh	72	2	48	48	CD
cord-270892-ycc3csyh	72	3	]	]	-RRB-
cord-270892-ycc3csyh	72	4	[	[	-LRB-
cord-270892-ycc3csyh	72	5	49	49	CD
cord-270892-ycc3csyh	72	6	]	]	-RRB-
cord-270892-ycc3csyh	72	7	chronic	chronic	JJ
cord-270892-ycc3csyh	72	8	obstructive	obstructive	JJ
cord-270892-ycc3csyh	72	9	pulmonary	pulmonary	JJ
cord-270892-ycc3csyh	72	10	disease	disease	NN
cord-270892-ycc3csyh	72	11	,	,	,
cord-270892-ycc3csyh	72	12	[	[	-LRB-
cord-270892-ycc3csyh	72	13	50	50	CD
cord-270892-ycc3csyh	72	14	]	]	-RRB-
cord-270892-ycc3csyh	72	15	[	[	-LRB-
cord-270892-ycc3csyh	72	16	51	51	CD
cord-270892-ycc3csyh	72	17	]	]	-RRB-
cord-270892-ycc3csyh	72	18	[	[	-LRB-
cord-270892-ycc3csyh	72	19	52	52	CD
cord-270892-ycc3csyh	72	20	]	]	-RRB-
cord-270892-ycc3csyh	72	21	[	[	-LRB-
cord-270892-ycc3csyh	72	22	53	53	CD
cord-270892-ycc3csyh	72	23	]	]	-RRB-
cord-270892-ycc3csyh	72	24	[	[	-LRB-
cord-270892-ycc3csyh	72	25	54	54	CD
cord-270892-ycc3csyh	72	26	]	]	-RRB-
cord-270892-ycc3csyh	72	27	[	[	-LRB-
cord-270892-ycc3csyh	72	28	55	55	CD
cord-270892-ycc3csyh	72	29	]	]	-RRB-
cord-270892-ycc3csyh	72	30	and	and	CC
cord-270892-ycc3csyh	72	31	cystic	cystic	JJ
cord-270892-ycc3csyh	72	32	fibrosis	fibrosis	NN
cord-270892-ycc3csyh	72	33	.	.	.
cord-270892-ycc3csyh	73	1	[	[	-LRB-
cord-270892-ycc3csyh	73	2	56	56	CD
cord-270892-ycc3csyh	73	3	]	]	-RRB-
cord-270892-ycc3csyh	73	4	[	[	-LRB-
cord-270892-ycc3csyh	73	5	57	57	CD
cord-270892-ycc3csyh	73	6	]	]	-RRB-
cord-270892-ycc3csyh	73	7	[	[	-LRB-
cord-270892-ycc3csyh	73	8	58	58	CD
cord-270892-ycc3csyh	73	9	]	]	-RRB-
cord-270892-ycc3csyh	74	1	The	the	DT
cord-270892-ycc3csyh	74	2	recently	recently	RB
cord-270892-ycc3csyh	74	3	discovered	discover	VBN
cord-270892-ycc3csyh	74	4	novel	novel	JJ
cord-270892-ycc3csyh	74	5	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	74	6	genotype	genotype	NN
cord-270892-ycc3csyh	74	7	HRV	HRV	NNP
cord-270892-ycc3csyh	74	8	-	-	HYPH
cord-270892-ycc3csyh	74	9	C	C	NNP
cord-270892-ycc3csyh	74	10	was	be	VBD
cord-270892-ycc3csyh	74	11	associated	associate	VBN
cord-270892-ycc3csyh	74	12	with	with	IN
cord-270892-ycc3csyh	74	13	community	community	NN
cord-270892-ycc3csyh	74	14	outbreaks	outbreak	NNS
cord-270892-ycc3csyh	74	15	of	of	IN
cord-270892-ycc3csyh	74	16	influenza	influenza	NN
cord-270892-ycc3csyh	74	17	-	-	HYPH
cord-270892-ycc3csyh	74	18	like	like	JJ
cord-270892-ycc3csyh	74	19	,	,	,
cord-270892-ycc3csyh	74	20	acute	acute	JJ
cord-270892-ycc3csyh	74	21	upper	upper	JJ
cord-270892-ycc3csyh	74	22	respiratory	respiratory	JJ
cord-270892-ycc3csyh	74	23	infections	infection	NNS
cord-270892-ycc3csyh	74	24	and	and	CC
cord-270892-ycc3csyh	74	25	severe	severe	JJ
cord-270892-ycc3csyh	74	26	low	low	JJ
cord-270892-ycc3csyh	74	27	respiratory	respiratory	JJ
cord-270892-ycc3csyh	74	28	tract	tract	NN
cord-270892-ycc3csyh	74	29	infections	infection	NNS
cord-270892-ycc3csyh	74	30	of	of	IN
cord-270892-ycc3csyh	74	31	infants	infant	NNS
cord-270892-ycc3csyh	75	1	e.g.	e.g.	IN
cord-270892-ycc3csyh	75	2	febrile	febrile	JJ
cord-270892-ycc3csyh	75	3	wheeze	wheeze	NN
cord-270892-ycc3csyh	75	4	,	,	,
cord-270892-ycc3csyh	75	5	bronchiolytis	bronchiolytis	NNP
cord-270892-ycc3csyh	75	6	,	,	,
cord-270892-ycc3csyh	75	7	and	and	CC
cord-270892-ycc3csyh	75	8	asthma	asthma	NN
cord-270892-ycc3csyh	75	9	exacerbations	exacerbation	NNS
cord-270892-ycc3csyh	75	10	,	,	,
cord-270892-ycc3csyh	75	11	which	which	WDT
cord-270892-ycc3csyh	75	12	peaked	peak	VBD
cord-270892-ycc3csyh	75	13	in	in	IN
cord-270892-ycc3csyh	75	14	fall	fall	NN
cord-270892-ycc3csyh	75	15	and	and	CC
cord-270892-ycc3csyh	75	16	winter	winter	NN
cord-270892-ycc3csyh	75	17	.	.	.
cord-270892-ycc3csyh	76	1	[	[	-LRB-
cord-270892-ycc3csyh	76	2	2	2	LS
cord-270892-ycc3csyh	76	3	]	]	-RRB-
cord-270892-ycc3csyh	76	4	[	[	-LRB-
cord-270892-ycc3csyh	76	5	3	3	CD
cord-270892-ycc3csyh	76	6	]	]	-RRB-
cord-270892-ycc3csyh	76	7	[	[	-LRB-
cord-270892-ycc3csyh	76	8	4	4	CD
cord-270892-ycc3csyh	76	9	]	]	-RRB-
cord-270892-ycc3csyh	76	10	[	[	-LRB-
cord-270892-ycc3csyh	76	11	5	5	CD
cord-270892-ycc3csyh	76	12	]	]	-RRB-
cord-270892-ycc3csyh	76	13	[	[	-LRB-
cord-270892-ycc3csyh	76	14	6	6	CD
cord-270892-ycc3csyh	76	15	]	]	-RRB-
cord-270892-ycc3csyh	76	16	26	26	CD
cord-270892-ycc3csyh	76	17	,	,	,
cord-270892-ycc3csyh	76	18	59	59	CD
cord-270892-ycc3csyh	76	19	,	,	,
cord-270892-ycc3csyh	76	20	60	60	CD
cord-270892-ycc3csyh	77	1	In	in	IN
cord-270892-ycc3csyh	77	2	addition	addition	NN
cord-270892-ycc3csyh	77	3	,	,	,
cord-270892-ycc3csyh	77	4	the	the	DT
cord-270892-ycc3csyh	77	5	presence	presence	NN
cord-270892-ycc3csyh	77	6	of	of	IN
cord-270892-ycc3csyh	77	7	HRV	HRV	NNP
cord-270892-ycc3csyh	77	8	-	-	HYPH
cord-270892-ycc3csyh	77	9	C	C	NNP
cord-270892-ycc3csyh	77	10	in	in	IN
cord-270892-ycc3csyh	77	11	the	the	DT
cord-270892-ycc3csyh	77	12	middle	middle	JJ
cord-270892-ycc3csyh	77	13	ear	ear	NN
cord-270892-ycc3csyh	77	14	in	in	IN
cord-270892-ycc3csyh	77	15	patients	patient	NNS
cord-270892-ycc3csyh	77	16	with	with	IN
cord-270892-ycc3csyh	77	17	acute	acute	JJ
cord-270892-ycc3csyh	77	18	otitis	otitis	NN
cord-270892-ycc3csyh	77	19	media	medium	NNS
cord-270892-ycc3csyh	77	20	was	be	VBD
cord-270892-ycc3csyh	77	21	demonstrated	demonstrate	VBN
cord-270892-ycc3csyh	77	22	.	.	.
cord-270892-ycc3csyh	78	1	37	37	CD
cord-270892-ycc3csyh	78	2	 	 	_SP
cord-270892-ycc3csyh	78	3	HRV	HRV	NNP
cord-270892-ycc3csyh	78	4	spread	spread	NN
cord-270892-ycc3csyh	78	5	occurs	occur	VBZ
cord-270892-ycc3csyh	78	6	by	by	IN
cord-270892-ycc3csyh	78	7	means	mean	NNS
cord-270892-ycc3csyh	78	8	of	of	IN
cord-270892-ycc3csyh	78	9	virus	virus	NN
cord-270892-ycc3csyh	78	10	-	-	HYPH
cord-270892-ycc3csyh	78	11	contaminated	contaminate	VBN
cord-270892-ycc3csyh	78	12	respiratory	respiratory	JJ
cord-270892-ycc3csyh	78	13	secretions	secretion	NNS
cord-270892-ycc3csyh	78	14	that	that	WDT
cord-270892-ycc3csyh	78	15	contain	contain	VBP
cord-270892-ycc3csyh	78	16	a	a	DT
cord-270892-ycc3csyh	78	17	high	high	JJ
cord-270892-ycc3csyh	78	18	virus	virus	NN
cord-270892-ycc3csyh	78	19	concentration	concentration	NN
cord-270892-ycc3csyh	78	20	.	.	.
cord-270892-ycc3csyh	79	1	[	[	-LRB-
cord-270892-ycc3csyh	79	2	61	61	CD
cord-270892-ycc3csyh	79	3	]	]	-RRB-
cord-270892-ycc3csyh	79	4	[	[	-LRB-
cord-270892-ycc3csyh	79	5	62	62	CD
cord-270892-ycc3csyh	79	6	]	]	-RRB-
cord-270892-ycc3csyh	80	1	[	[	-LRB-
cord-270892-ycc3csyh	80	2	63	63	CD
cord-270892-ycc3csyh	80	3	]	]	-RRB-
cord-270892-ycc3csyh	81	1	Besides	besides	IN
cord-270892-ycc3csyh	81	2	direct	direct	JJ
cord-270892-ycc3csyh	81	3	hand	hand	NN
cord-270892-ycc3csyh	81	4	-	-	HYPH
cord-270892-ycc3csyh	81	5	to	to	IN
cord-270892-ycc3csyh	81	6	-	-	HYPH
cord-270892-ycc3csyh	81	7	hand	hand	NN
cord-270892-ycc3csyh	81	8	transmission	transmission	NN
cord-270892-ycc3csyh	81	9	,	,	,
cord-270892-ycc3csyh	81	10	small	small	JJ
cord-270892-ycc3csyh	81	11	-	-	HYPH
cord-270892-ycc3csyh	81	12	and	and	CC
cord-270892-ycc3csyh	81	13	largeparticle	largeparticle	NNP
cord-270892-ycc3csyh	81	14	aerosol	aerosol	NN
cord-270892-ycc3csyh	81	15	transmission	transmission	NN
cord-270892-ycc3csyh	81	16	of	of	IN
cord-270892-ycc3csyh	81	17	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	81	18	has	have	VBZ
cord-270892-ycc3csyh	81	19	been	be	VBN
cord-270892-ycc3csyh	81	20	shown	show	VBN
cord-270892-ycc3csyh	81	21	.	.	.
cord-270892-ycc3csyh	82	1	61	61	CD
cord-270892-ycc3csyh	82	2	,	,	,
cord-270892-ycc3csyh	82	3	64	64	CD
cord-270892-ycc3csyh	82	4	,	,	,
cord-270892-ycc3csyh	82	5	65	65	CD
cord-270892-ycc3csyh	82	6	Children	child	NNS
cord-270892-ycc3csyh	82	7	are	be	VBP
cord-270892-ycc3csyh	82	8	important	important	JJ
cord-270892-ycc3csyh	82	9	'	'	''
cord-270892-ycc3csyh	82	10	'	'	``
cord-270892-ycc3csyh	82	11	vectors	vector	NNS
cord-270892-ycc3csyh	82	12	'	'	''
cord-270892-ycc3csyh	82	13	'	'	''
cord-270892-ycc3csyh	82	14	for	for	IN
cord-270892-ycc3csyh	82	15	HRV	HRV	NNP
cord-270892-ycc3csyh	82	16	transmission	transmission	NN
cord-270892-ycc3csyh	82	17	to	to	IN
cord-270892-ycc3csyh	82	18	family	family	NN
cord-270892-ycc3csyh	82	19	members	member	NNS
cord-270892-ycc3csyh	82	20	.	.	.
cord-270892-ycc3csyh	83	1	25	25	CD
cord-270892-ycc3csyh	84	1	Moreover	moreover	RB
cord-270892-ycc3csyh	84	2	,	,	,
cord-270892-ycc3csyh	84	3	studies	study	NNS
cord-270892-ycc3csyh	84	4	with	with	IN
cord-270892-ycc3csyh	84	5	natural	natural	JJ
cord-270892-ycc3csyh	84	6	HRV	HRV	NNP
cord-270892-ycc3csyh	84	7	-	-	HYPH
cord-270892-ycc3csyh	84	8	infected	infect	VBN
cord-270892-ycc3csyh	84	9	adults	adult	NNS
cord-270892-ycc3csyh	84	10	provided	provide	VBD
cord-270892-ycc3csyh	84	11	evidence	evidence	NN
cord-270892-ycc3csyh	84	12	that	that	IN
cord-270892-ycc3csyh	84	13	daily	daily	JJ
cord-270892-ycc3csyh	84	14	activities	activity	NNS
cord-270892-ycc3csyh	84	15	of	of	IN
cord-270892-ycc3csyh	84	16	infected	infected	JJ
cord-270892-ycc3csyh	84	17	people	people	NNS
cord-270892-ycc3csyh	84	18	can	can	MD
cord-270892-ycc3csyh	84	19	lead	lead	VB
cord-270892-ycc3csyh	84	20	to	to	IN
cord-270892-ycc3csyh	84	21	contamination	contamination	NN
cord-270892-ycc3csyh	84	22	of	of	IN
cord-270892-ycc3csyh	84	23	environmental	environmental	JJ
cord-270892-ycc3csyh	84	24	surfaces	surface	NNS
cord-270892-ycc3csyh	84	25	with	with	IN
cord-270892-ycc3csyh	84	26	HRV	HRV	NNP
cord-270892-ycc3csyh	85	1	e.g.	e.g.	IN
cord-270892-ycc3csyh	85	2	light	light	JJ
cord-270892-ycc3csyh	85	3	switches	switch	NNS
cord-270892-ycc3csyh	85	4	,	,	,
cord-270892-ycc3csyh	85	5	telephone	telephone	NN
cord-270892-ycc3csyh	85	6	dial	dial	NN
cord-270892-ycc3csyh	85	7	buttons	button	NNS
cord-270892-ycc3csyh	85	8	and	and	CC
cord-270892-ycc3csyh	85	9	handsets	handset	NNS
cord-270892-ycc3csyh	85	10	,	,	,
cord-270892-ycc3csyh	85	11	and	and	CC
cord-270892-ycc3csyh	85	12	virus	virus	NN
cord-270892-ycc3csyh	85	13	transfer	transfer	NN
cord-270892-ycc3csyh	85	14	to	to	IN
cord-270892-ycc3csyh	85	15	fingers	finger	NNS
cord-270892-ycc3csyh	85	16	of	of	IN
cord-270892-ycc3csyh	85	17	healthy	healthy	JJ
cord-270892-ycc3csyh	85	18	individuals	individual	NNS
cord-270892-ycc3csyh	85	19	for	for	IN
cord-270892-ycc3csyh	85	20	infection	infection	NN
cord-270892-ycc3csyh	85	21	.	.	.
cord-270892-ycc3csyh	86	1	63	63	CD
cord-270892-ycc3csyh	86	2	,	,	,
cord-270892-ycc3csyh	86	3	66	66	CD
cord-270892-ycc3csyh	87	1	Because	because	IN
cord-270892-ycc3csyh	87	2	viral	viral	JJ
cord-270892-ycc3csyh	87	3	contamination	contamination	NN
cord-270892-ycc3csyh	87	4	of	of	IN
cord-270892-ycc3csyh	87	5	the	the	DT
cord-270892-ycc3csyh	87	6	hands	hand	NNS
cord-270892-ycc3csyh	87	7	plays	play	VBZ
cord-270892-ycc3csyh	87	8	an	an	DT
cord-270892-ycc3csyh	87	9	important	important	JJ
cord-270892-ycc3csyh	87	10	role	role	NN
cord-270892-ycc3csyh	87	11	in	in	IN
cord-270892-ycc3csyh	87	12	transmission	transmission	NN
cord-270892-ycc3csyh	87	13	of	of	IN
cord-270892-ycc3csyh	87	14	HRV	HRV	NNP
cord-270892-ycc3csyh	87	15	from	from	IN
cord-270892-ycc3csyh	87	16	person	person	NN
cord-270892-ycc3csyh	87	17	-	-	HYPH
cord-270892-ycc3csyh	87	18	to	to	IN
cord-270892-ycc3csyh	87	19	-	-	HYPH
cord-270892-ycc3csyh	87	20	person	person	NN
cord-270892-ycc3csyh	87	21	,	,	,
cord-270892-ycc3csyh	87	22	interruption	interruption	NN
cord-270892-ycc3csyh	87	23	of	of	IN
cord-270892-ycc3csyh	87	24	this	this	DT
cord-270892-ycc3csyh	87	25	step	step	NN
cord-270892-ycc3csyh	87	26	of	of	IN
cord-270892-ycc3csyh	87	27	virus	virus	NN
cord-270892-ycc3csyh	87	28	transmission	transmission	NN
cord-270892-ycc3csyh	87	29	presents	present	VBZ
cord-270892-ycc3csyh	87	30	a	a	DT
cord-270892-ycc3csyh	87	31	potential	potential	JJ
cord-270892-ycc3csyh	87	32	target	target	NN
cord-270892-ycc3csyh	87	33	for	for	IN
cord-270892-ycc3csyh	87	34	intervention	intervention	NN
cord-270892-ycc3csyh	87	35	.	.	.
cord-270892-ycc3csyh	88	1	This	this	DT
cord-270892-ycc3csyh	88	2	was	be	VBD
cord-270892-ycc3csyh	88	3	experimentally	experimentally	RB
cord-270892-ycc3csyh	88	4	proved	prove	VBN
cord-270892-ycc3csyh	88	5	by	by	IN
cord-270892-ycc3csyh	88	6	treatment	treatment	NN
cord-270892-ycc3csyh	88	7	of	of	IN
cord-270892-ycc3csyh	88	8	hands	hand	NNS
cord-270892-ycc3csyh	88	9	by	by	IN
cord-270892-ycc3csyh	88	10	iodine	iodine	NN
cord-270892-ycc3csyh	88	11	67	67	CD
cord-270892-ycc3csyh	88	12	,	,	,
cord-270892-ycc3csyh	88	13	68	68	CD
cord-270892-ycc3csyh	88	14	or	or	CC
cord-270892-ycc3csyh	88	15	salicylic	salicylic	JJ
cord-270892-ycc3csyh	88	16	and	and	CC
cord-270892-ycc3csyh	88	17	pyroglutamic	pyroglutamic	JJ
cord-270892-ycc3csyh	88	18	acid	acid	NN
cord-270892-ycc3csyh	88	19	.	.	.
cord-270892-ycc3csyh	89	1	69	69	CD
cord-270892-ycc3csyh	89	2	 	 	_SP
cord-270892-ycc3csyh	90	1	Observations	observation	NNS
cord-270892-ycc3csyh	90	2	from	from	IN
cord-270892-ycc3csyh	90	3	experimentally	experimentally	RB
cord-270892-ycc3csyh	90	4	induced	induce	VBN
cord-270892-ycc3csyh	90	5	infections	infection	NNS
cord-270892-ycc3csyh	90	6	in	in	IN
cord-270892-ycc3csyh	90	7	normal	normal	JJ
cord-270892-ycc3csyh	90	8	adult	adult	NN
cord-270892-ycc3csyh	90	9	volunteers	volunteer	NNS
cord-270892-ycc3csyh	90	10	helped	help	VBD
cord-270892-ycc3csyh	90	11	to	to	TO
cord-270892-ycc3csyh	90	12	understand	understand	VB
cord-270892-ycc3csyh	90	13	the	the	DT
cord-270892-ycc3csyh	90	14	pathogenesis	pathogenesis	NN
cord-270892-ycc3csyh	90	15	of	of	IN
cord-270892-ycc3csyh	90	16	HRV	HRV	NNP
cord-270892-ycc3csyh	90	17	infections	infection	NNS
cord-270892-ycc3csyh	90	18	.	.	.
cord-270892-ycc3csyh	91	1	[	[	-LRB-
cord-270892-ycc3csyh	91	2	70	70	CD
cord-270892-ycc3csyh	91	3	]	]	-RRB-
cord-270892-ycc3csyh	91	4	[	[	-LRB-
cord-270892-ycc3csyh	91	5	71	71	CD
cord-270892-ycc3csyh	91	6	]	]	-RRB-
cord-270892-ycc3csyh	92	1	[	[	-LRB-
cord-270892-ycc3csyh	92	2	72	72	CD
cord-270892-ycc3csyh	92	3	]	]	-RRB-
cord-270892-ycc3csyh	92	4	[	[	-LRB-
cord-270892-ycc3csyh	92	5	73	73	CD
cord-270892-ycc3csyh	92	6	]	]	-RRB-
cord-270892-ycc3csyh	92	7	[	[	-LRB-
cord-270892-ycc3csyh	92	8	74	74	CD
cord-270892-ycc3csyh	92	9	]	]	-RRB-
cord-270892-ycc3csyh	93	1	[	[	-LRB-
cord-270892-ycc3csyh	93	2	75	75	CD
cord-270892-ycc3csyh	93	3	]	]	-RRB-
cord-270892-ycc3csyh	94	1	The	the	DT
cord-270892-ycc3csyh	94	2	50	50	CD
cord-270892-ycc3csyh	94	3	%	%	NN
cord-270892-ycc3csyh	94	4	human	human	JJ
cord-270892-ycc3csyh	94	5	infectious	infectious	JJ
cord-270892-ycc3csyh	94	6	dose	dose	NN
cord-270892-ycc3csyh	94	7	of	of	IN
cord-270892-ycc3csyh	94	8	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	94	9	is	be	VBZ
cord-270892-ycc3csyh	94	10	low	low	JJ
cord-270892-ycc3csyh	94	11	and	and	CC
cord-270892-ycc3csyh	94	12	the	the	DT
cord-270892-ycc3csyh	94	13	infection	infection	NN
cord-270892-ycc3csyh	94	14	rate	rate	NN
cord-270892-ycc3csyh	94	15	between	between	IN
cord-270892-ycc3csyh	94	16	70	70	CD
cord-270892-ycc3csyh	94	17	and	and	CC
cord-270892-ycc3csyh	94	18	80	80	CD
cord-270892-ycc3csyh	94	19	%	%	NN
cord-270892-ycc3csyh	94	20	.	.	.
cord-270892-ycc3csyh	95	1	After	after	IN
cord-270892-ycc3csyh	95	2	the	the	DT
cord-270892-ycc3csyh	95	3	deposition	deposition	NN
cord-270892-ycc3csyh	95	4	of	of	IN
cord-270892-ycc3csyh	95	5	HRV	HRV	NNP
cord-270892-ycc3csyh	95	6	on	on	IN
cord-270892-ycc3csyh	95	7	nasal	nasal	NN
cord-270892-ycc3csyh	95	8	or	or	CC
cord-270892-ycc3csyh	95	9	conjunctival	conjunctival	NN
cord-270892-ycc3csyh	95	10	mucosa	mucosa	NN
cord-270892-ycc3csyh	95	11	,	,	,
cord-270892-ycc3csyh	95	12	viruses	virus	NNS
cord-270892-ycc3csyh	95	13	are	be	VBP
cord-270892-ycc3csyh	95	14	transported	transport	VBN
cord-270892-ycc3csyh	95	15	to	to	IN
cord-270892-ycc3csyh	95	16	the	the	DT
cord-270892-ycc3csyh	95	17	posterior	posterior	JJ
cord-270892-ycc3csyh	95	18	nasopharynx	nasopharynx	NN
cord-270892-ycc3csyh	95	19	by	by	IN
cord-270892-ycc3csyh	95	20	mucociliary	mucociliary	JJ
cord-270892-ycc3csyh	95	21	action	action	NN
cord-270892-ycc3csyh	95	22	of	of	IN
cord-270892-ycc3csyh	95	23	epithelial	epithelial	JJ
cord-270892-ycc3csyh	95	24	cells	cell	NNS
cord-270892-ycc3csyh	95	25	.	.	.
cord-270892-ycc3csyh	96	1	Specific	specific	JJ
cord-270892-ycc3csyh	96	2	receptors	receptor	NNS
cord-270892-ycc3csyh	96	3	on	on	IN
cord-270892-ycc3csyh	96	4	epithelial	epithelial	JJ
cord-270892-ycc3csyh	96	5	cells	cell	NNS
cord-270892-ycc3csyh	96	6	in	in	IN
cord-270892-ycc3csyh	96	7	the	the	DT
cord-270892-ycc3csyh	96	8	adenoid	adenoid	JJ
cord-270892-ycc3csyh	96	9	area	area	NN
cord-270892-ycc3csyh	96	10	are	be	VBP
cord-270892-ycc3csyh	96	11	used	use	VBN
cord-270892-ycc3csyh	96	12	for	for	IN
cord-270892-ycc3csyh	96	13	binding	binding	NN
cord-270892-ycc3csyh	96	14	and	and	CC
cord-270892-ycc3csyh	96	15	entry	entry	NN
cord-270892-ycc3csyh	96	16	.	.	.
cord-270892-ycc3csyh	97	1	Already	already	RB
cord-270892-ycc3csyh	97	2	8	8	CD
cord-270892-ycc3csyh	97	3	-	-	SYM
cord-270892-ycc3csyh	97	4	10	10	CD
cord-270892-ycc3csyh	97	5	hr	hr	NN
cord-270892-ycc3csyh	97	6	after	after	IN
cord-270892-ycc3csyh	97	7	intranasal	intranasal	NN
cord-270892-ycc3csyh	97	8	inoculation	inoculation	NN
cord-270892-ycc3csyh	97	9	,	,	,
cord-270892-ycc3csyh	97	10	infectious	infectious	JJ
cord-270892-ycc3csyh	97	11	virus	virus	NN
cord-270892-ycc3csyh	97	12	can	can	MD
cord-270892-ycc3csyh	97	13	be	be	VB
cord-270892-ycc3csyh	97	14	detected	detect	VBN
cord-270892-ycc3csyh	97	15	.	.	.
cord-270892-ycc3csyh	98	1	76	76	CD
cord-270892-ycc3csyh	98	2	Virus	virus	NN
cord-270892-ycc3csyh	98	3	shedding	shed	VBG
cord-270892-ycc3csyh	98	4	peaks	peak	NNS
cord-270892-ycc3csyh	98	5	on	on	IN
cord-270892-ycc3csyh	98	6	the	the	DT
cord-270892-ycc3csyh	98	7	second	second	JJ
cord-270892-ycc3csyh	98	8	day	day	NN
cord-270892-ycc3csyh	98	9	after	after	IN
cord-270892-ycc3csyh	98	10	infection	infection	NN
cord-270892-ycc3csyh	98	11	and	and	CC
cord-270892-ycc3csyh	98	12	decreases	decrease	NNS
cord-270892-ycc3csyh	98	13	rapidly	rapidly	RB
cord-270892-ycc3csyh	98	14	thereafter	thereafter	RB
cord-270892-ycc3csyh	98	15	.	.	.
cord-270892-ycc3csyh	99	1	75	75	CD
cord-270892-ycc3csyh	100	1	But	but	CC
cord-270892-ycc3csyh	100	2	,	,	,
cord-270892-ycc3csyh	100	3	small	small	JJ
cord-270892-ycc3csyh	100	4	amounts	amount	NNS
cord-270892-ycc3csyh	100	5	of	of	IN
cord-270892-ycc3csyh	100	6	viruses	virus	NNS
cord-270892-ycc3csyh	100	7	were	be	VBD
cord-270892-ycc3csyh	100	8	discovered	discover	VBN
cord-270892-ycc3csyh	100	9	in	in	IN
cord-270892-ycc3csyh	100	10	nasal	nasal	JJ
cord-270892-ycc3csyh	100	11	secretions	secretion	NNS
cord-270892-ycc3csyh	100	12	for	for	IN
cord-270892-ycc3csyh	100	13	up	up	IN
cord-270892-ycc3csyh	100	14	to	to	TO
cord-270892-ycc3csyh	100	15	3	3	CD
cord-270892-ycc3csyh	100	16	weeks	week	NNS
cord-270892-ycc3csyh	100	17	after	after	IN
cord-270892-ycc3csyh	100	18	infection	infection	NN
cord-270892-ycc3csyh	100	19	.	.	.
cord-270892-ycc3csyh	101	1	Virus	virus	NN
cord-270892-ycc3csyh	101	2	and/or	and/or	CC
cord-270892-ycc3csyh	101	3	viral	viral	JJ
cord-270892-ycc3csyh	101	4	RNA	RNA	NNP
cord-270892-ycc3csyh	101	5	were	be	VBD
cord-270892-ycc3csyh	101	6	demonstrated	demonstrate	VBN
cord-270892-ycc3csyh	101	7	in	in	IN
cord-270892-ycc3csyh	101	8	the	the	DT
cord-270892-ycc3csyh	101	9	upper	upper	JJ
cord-270892-ycc3csyh	101	10	70	70	CD
cord-270892-ycc3csyh	101	11	as	as	RB
cord-270892-ycc3csyh	101	12	well	well	RB
cord-270892-ycc3csyh	101	13	as	as	IN
cord-270892-ycc3csyh	101	14	lower	low	JJR
cord-270892-ycc3csyh	101	15	respiratory	respiratory	JJ
cord-270892-ycc3csyh	101	16	tract	tract	NN
cord-270892-ycc3csyh	101	17	.	.	.
cord-270892-ycc3csyh	102	1	45	45	CD
cord-270892-ycc3csyh	102	2	,	,	,
cord-270892-ycc3csyh	102	3	72	72	CD
cord-270892-ycc3csyh	102	4	,	,	,
cord-270892-ycc3csyh	102	5	77	77	CD
cord-270892-ycc3csyh	102	6	,	,	,
cord-270892-ycc3csyh	102	7	78	78	CD
cord-270892-ycc3csyh	102	8	Using	use	VBG
cord-270892-ycc3csyh	102	9	in	in	IN
cord-270892-ycc3csyh	102	10	situ	situ	NN
cord-270892-ycc3csyh	102	11	hybridization	hybridization	NN
cord-270892-ycc3csyh	102	12	,	,	,
cord-270892-ycc3csyh	102	13	Arruda	Arruda	NNP
cord-270892-ycc3csyh	102	14	et	et	NNP
cord-270892-ycc3csyh	102	15	al	al	NNP
cord-270892-ycc3csyh	102	16	.	.	.
cord-270892-ycc3csyh	103	1	(	(	-LRB-
cord-270892-ycc3csyh	103	2	1995	1995	CD
cord-270892-ycc3csyh	103	3	)	)	-RRB-
cord-270892-ycc3csyh	103	4	detected	detect	VBD
cord-270892-ycc3csyh	103	5	viral	viral	JJ
cord-270892-ycc3csyh	103	6	RNA	RNA	NNP
cord-270892-ycc3csyh	103	7	in	in	IN
cord-270892-ycc3csyh	103	8	a	a	DT
cord-270892-ycc3csyh	103	9	low	low	JJ
cord-270892-ycc3csyh	103	10	number	number	NN
cord-270892-ycc3csyh	103	11	of	of	IN
cord-270892-ycc3csyh	103	12	ciliated	ciliated	JJ
cord-270892-ycc3csyh	103	13	cells	cell	NNS
cord-270892-ycc3csyh	103	14	in	in	IN
cord-270892-ycc3csyh	103	15	nasal	nasal	NN
cord-270892-ycc3csyh	103	16	biopsies	biopsy	NNS
cord-270892-ycc3csyh	103	17	.	.	.
cord-270892-ycc3csyh	104	1	In	in	IN
cord-270892-ycc3csyh	104	2	the	the	DT
cord-270892-ycc3csyh	104	3	nasopharynx	nasopharynx	NN
cord-270892-ycc3csyh	104	4	,	,	,
cord-270892-ycc3csyh	104	5	a	a	DT
cord-270892-ycc3csyh	104	6	small	small	JJ
cord-270892-ycc3csyh	104	7	portion	portion	NN
cord-270892-ycc3csyh	104	8	of	of	IN
cord-270892-ycc3csyh	104	9	virus	virus	NN
cord-270892-ycc3csyh	104	10	-	-	HYPH
cord-270892-ycc3csyh	104	11	positive	positive	JJ
cord-270892-ycc3csyh	104	12	ciliated	ciliated	JJ
cord-270892-ycc3csyh	104	13	as	as	RB
cord-270892-ycc3csyh	104	14	well	well	RB
cord-270892-ycc3csyh	104	15	as	as	IN
cord-270892-ycc3csyh	104	16	nonciliated	nonciliate	VBN
cord-270892-ycc3csyh	104	17	cells	cell	NNS
cord-270892-ycc3csyh	104	18	was	be	VBD
cord-270892-ycc3csyh	104	19	positive	positive	JJ
cord-270892-ycc3csyh	104	20	for	for	IN
cord-270892-ycc3csyh	104	21	viral	viral	JJ
cord-270892-ycc3csyh	104	22	RNA	RNA	NNP
cord-270892-ycc3csyh	104	23	.	.	.
cord-270892-ycc3csyh	105	1	In	in	IN
cord-270892-ycc3csyh	105	2	2000	2000	CD
cord-270892-ycc3csyh	105	3	Papadopoulos	Papadopoulos	NNP
cord-270892-ycc3csyh	105	4	et	et	NNP
cord-270892-ycc3csyh	105	5	al	al	NNP
cord-270892-ycc3csyh	105	6	.	.	.
cord-270892-ycc3csyh	106	1	provided	provide	VBN
cord-270892-ycc3csyh	106	2	evidence	evidence	NN
cord-270892-ycc3csyh	106	3	that	that	IN
cord-270892-ycc3csyh	106	4	HRV	HRV	NNP
cord-270892-ycc3csyh	106	5	may	may	MD
cord-270892-ycc3csyh	106	6	also	also	RB
cord-270892-ycc3csyh	106	7	lytically	lytically	RB
cord-270892-ycc3csyh	106	8	infect	infect	VB
cord-270892-ycc3csyh	106	9	human	human	JJ
cord-270892-ycc3csyh	106	10	bronchial	bronchial	JJ
cord-270892-ycc3csyh	106	11	epithelial	epithelial	JJ
cord-270892-ycc3csyh	106	12	cells	cell	NNS
cord-270892-ycc3csyh	106	13	in	in	IN
cord-270892-ycc3csyh	106	14	cell	cell	NN
cord-270892-ycc3csyh	106	15	culture	culture	NN
cord-270892-ycc3csyh	106	16	as	as	RB
cord-270892-ycc3csyh	106	17	well	well	RB
cord-270892-ycc3csyh	106	18	as	as	IN
cord-270892-ycc3csyh	106	19	in	in	IN
cord-270892-ycc3csyh	106	20	experimentally	experimentally	RB
cord-270892-ycc3csyh	106	21	infected	infect	VBN
cord-270892-ycc3csyh	106	22	volunteers	volunteer	NNS
cord-270892-ycc3csyh	106	23	and	and	CC
cord-270892-ycc3csyh	106	24	induce	induce	VB
cord-270892-ycc3csyh	106	25	the	the	DT
cord-270892-ycc3csyh	106	26	production	production	NN
cord-270892-ycc3csyh	106	27	of	of	IN
cord-270892-ycc3csyh	106	28	interleukin-6	interleukin-6	NNP
cord-270892-ycc3csyh	106	29	,	,	,
cord-270892-ycc3csyh	106	30	-8	-8	NNP
cord-270892-ycc3csyh	106	31	,	,	,
cord-270892-ycc3csyh	106	32	and	and	CC
cord-270892-ycc3csyh	106	33	-16	-16	NN
cord-270892-ycc3csyh	106	34	.	.	.
cord-270892-ycc3csyh	107	1	In	in	IN
cord-270892-ycc3csyh	107	2	agreement	agreement	NN
cord-270892-ycc3csyh	107	3	with	with	IN
cord-270892-ycc3csyh	107	4	these	these	DT
cord-270892-ycc3csyh	107	5	results	result	NNS
cord-270892-ycc3csyh	107	6	,	,	,
cord-270892-ycc3csyh	107	7	HRV	HRV	NNP
cord-270892-ycc3csyh	107	8	RNA	RNA	NNP
cord-270892-ycc3csyh	107	9	was	be	VBD
cord-270892-ycc3csyh	107	10	detected	detect	VBN
cord-270892-ycc3csyh	107	11	in	in	IN
cord-270892-ycc3csyh	107	12	24	24	CD
cord-270892-ycc3csyh	107	13	-	-	SYM
cord-270892-ycc3csyh	107	14	45	45	CD
cord-270892-ycc3csyh	107	15	%	%	NN
cord-270892-ycc3csyh	107	16	of	of	IN
cord-270892-ycc3csyh	107	17	children	child	NNS
cord-270892-ycc3csyh	107	18	and	and	CC
cord-270892-ycc3csyh	107	19	10	10	CD
cord-270892-ycc3csyh	107	20	-	-	SYM
cord-270892-ycc3csyh	107	21	18	18	CD
cord-270892-ycc3csyh	107	22	%	%	NN
cord-270892-ycc3csyh	107	23	of	of	IN
cord-270892-ycc3csyh	107	24	adults	adult	NNS
cord-270892-ycc3csyh	107	25	with	with	IN
cord-270892-ycc3csyh	107	26	pneumonia	pneumonia	NN
cord-270892-ycc3csyh	107	27	.	.	.
cord-270892-ycc3csyh	108	1	[	[	-LRB-
cord-270892-ycc3csyh	108	2	79	79	CD
cord-270892-ycc3csyh	108	3	]	]	-RRB-
cord-270892-ycc3csyh	108	4	[	[	-LRB-
cord-270892-ycc3csyh	108	5	80	80	CD
cord-270892-ycc3csyh	108	6	]	]	-RRB-
cord-270892-ycc3csyh	109	1	[	[	-LRB-
cord-270892-ycc3csyh	109	2	81	81	CD
cord-270892-ycc3csyh	109	3	]	]	-RRB-
cord-270892-ycc3csyh	109	4	[	[	-LRB-
cord-270892-ycc3csyh	109	5	82	82	CD
cord-270892-ycc3csyh	109	6	]	]	-RRB-
cord-270892-ycc3csyh	110	1	Taken	take	VBN
cord-270892-ycc3csyh	110	2	together	together	RB
cord-270892-ycc3csyh	110	3	,	,	,
cord-270892-ycc3csyh	110	4	the	the	DT
cord-270892-ycc3csyh	110	5	results	result	NNS
cord-270892-ycc3csyh	110	6	of	of	IN
cord-270892-ycc3csyh	110	7	natural	natural	JJ
cord-270892-ycc3csyh	110	8	cold	cold	JJ
cord-270892-ycc3csyh	110	9	studies	study	NNS
cord-270892-ycc3csyh	110	10	as	as	RB
cord-270892-ycc3csyh	110	11	well	well	RB
cord-270892-ycc3csyh	110	12	as	as	IN
cord-270892-ycc3csyh	110	13	of	of	IN
cord-270892-ycc3csyh	110	14	experimental	experimental	JJ
cord-270892-ycc3csyh	110	15	infection	infection	NN
cord-270892-ycc3csyh	110	16	in	in	IN
cord-270892-ycc3csyh	110	17	human	human	JJ
cord-270892-ycc3csyh	110	18	volunteers	volunteer	NNS
cord-270892-ycc3csyh	110	19	clearly	clearly	RB
cord-270892-ycc3csyh	110	20	demonstrate	demonstrate	VBP
cord-270892-ycc3csyh	110	21	that	that	IN
cord-270892-ycc3csyh	110	22	HRV	HRV	NNP
cord-270892-ycc3csyh	110	23	are	be	VBP
cord-270892-ycc3csyh	110	24	able	able	JJ
cord-270892-ycc3csyh	110	25	to	to	TO
cord-270892-ycc3csyh	110	26	replicate	replicate	VB
cord-270892-ycc3csyh	110	27	in	in	IN
cord-270892-ycc3csyh	110	28	the	the	DT
cord-270892-ycc3csyh	110	29	upper	upper	NN
cord-270892-ycc3csyh	110	30	as	as	RB
cord-270892-ycc3csyh	110	31	well	well	RB
cord-270892-ycc3csyh	110	32	as	as	IN
cord-270892-ycc3csyh	110	33	in	in	IN
cord-270892-ycc3csyh	110	34	the	the	DT
cord-270892-ycc3csyh	110	35	lower	low	JJR
cord-270892-ycc3csyh	110	36	airways	airway	NNS
cord-270892-ycc3csyh	110	37	.	.	.
cord-270892-ycc3csyh	111	1	HRV	HRV	NNP
cord-270892-ycc3csyh	111	2	infection	infection	NN
cord-270892-ycc3csyh	111	3	triggers	trigger	VBZ
cord-270892-ycc3csyh	111	4	vasodilation	vasodilation	NN
cord-270892-ycc3csyh	111	5	and	and	CC
cord-270892-ycc3csyh	111	6	increased	increase	VBN
cord-270892-ycc3csyh	111	7	vascular	vascular	JJ
cord-270892-ycc3csyh	111	8	permeability	permeability	NN
cord-270892-ycc3csyh	111	9	in	in	IN
cord-270892-ycc3csyh	111	10	the	the	DT
cord-270892-ycc3csyh	111	11	nasal	nasal	NN
cord-270892-ycc3csyh	111	12	mucosa	mucosa	JJ
cord-270892-ycc3csyh	111	13	,	,	,
cord-270892-ycc3csyh	111	14	leading	lead	VBG
cord-270892-ycc3csyh	111	15	to	to	IN
cord-270892-ycc3csyh	111	16	nasal	nasal	JJ
cord-270892-ycc3csyh	111	17	obstruction	obstruction	NN
cord-270892-ycc3csyh	111	18	and	and	CC
cord-270892-ycc3csyh	111	19	rhinorrhoea	rhinorrhoea	NN
cord-270892-ycc3csyh	111	20	.	.	.
cord-270892-ycc3csyh	112	1	The	the	DT
cord-270892-ycc3csyh	112	2	mechanism	mechanism	NN
cord-270892-ycc3csyh	112	3	is	be	VBZ
cord-270892-ycc3csyh	112	4	still	still	RB
cord-270892-ycc3csyh	112	5	incompletely	incompletely	RB
cord-270892-ycc3csyh	112	6	understood	understand	VBN
cord-270892-ycc3csyh	112	7	because	because	IN
cord-270892-ycc3csyh	112	8	no	no	DT
cord-270892-ycc3csyh	112	9	histopathological	histopathological	JJ
cord-270892-ycc3csyh	112	10	changes	change	NNS
cord-270892-ycc3csyh	112	11	were	be	VBD
cord-270892-ycc3csyh	112	12	observed	observe	VBN
cord-270892-ycc3csyh	112	13	in	in	IN
cord-270892-ycc3csyh	112	14	nasal	nasal	JJ
cord-270892-ycc3csyh	112	15	biopsy	biopsy	NN
cord-270892-ycc3csyh	112	16	specimens	specimen	NNS
cord-270892-ycc3csyh	112	17	from	from	IN
cord-270892-ycc3csyh	112	18	infected	infected	JJ
cord-270892-ycc3csyh	112	19	persons	person	NNS
cord-270892-ycc3csyh	112	20	.	.	.
cord-270892-ycc3csyh	113	1	75	75	CD
cord-270892-ycc3csyh	114	1	This	this	DT
cord-270892-ycc3csyh	114	2	led	lead	VBD
cord-270892-ycc3csyh	114	3	to	to	IN
cord-270892-ycc3csyh	114	4	the	the	DT
cord-270892-ycc3csyh	114	5	suggestion	suggestion	NN
cord-270892-ycc3csyh	114	6	that	that	IN
cord-270892-ycc3csyh	114	7	clinical	clinical	JJ
cord-270892-ycc3csyh	114	8	symptoms	symptom	NNS
cord-270892-ycc3csyh	114	9	are	be	VBP
cord-270892-ycc3csyh	114	10	primarily	primarily	RB
cord-270892-ycc3csyh	114	11	caused	cause	VBN
cord-270892-ycc3csyh	114	12	by	by	IN
cord-270892-ycc3csyh	114	13	the	the	DT
cord-270892-ycc3csyh	114	14	inflammatory	inflammatory	JJ
cord-270892-ycc3csyh	114	15	response	response	NN
cord-270892-ycc3csyh	114	16	of	of	IN
cord-270892-ycc3csyh	114	17	the	the	DT
cord-270892-ycc3csyh	114	18	host	host	NN
cord-270892-ycc3csyh	114	19	to	to	IN
cord-270892-ycc3csyh	114	20	the	the	DT
cord-270892-ycc3csyh	114	21	virus	virus	NN
cord-270892-ycc3csyh	114	22	infection	infection	NN
cord-270892-ycc3csyh	114	23	and	and	CC
cord-270892-ycc3csyh	114	24	not	not	RB
cord-270892-ycc3csyh	114	25	by	by	IN
cord-270892-ycc3csyh	114	26	the	the	DT
cord-270892-ycc3csyh	114	27	cytopathic	cytopathic	JJ
cord-270892-ycc3csyh	114	28	effect	effect	NN
cord-270892-ycc3csyh	114	29	(	(	-LRB-
cord-270892-ycc3csyh	114	30	CPE	CPE	NNP
cord-270892-ycc3csyh	114	31	)	)	-RRB-
cord-270892-ycc3csyh	114	32	of	of	IN
cord-270892-ycc3csyh	114	33	HRV	HRV	NNP
cord-270892-ycc3csyh	114	34	.	.	.
cord-270892-ycc3csyh	115	1	Results	result	NNS
cord-270892-ycc3csyh	115	2	of	of	IN
cord-270892-ycc3csyh	115	3	immunological	immunological	JJ
cord-270892-ycc3csyh	115	4	investigations	investigation	NNS
cord-270892-ycc3csyh	115	5	suggest	suggest	VBP
cord-270892-ycc3csyh	115	6	a	a	DT
cord-270892-ycc3csyh	115	7	modest	modest	JJ
cord-270892-ycc3csyh	115	8	correlation	correlation	NN
cord-270892-ycc3csyh	115	9	between	between	IN
cord-270892-ycc3csyh	115	10	the	the	DT
cord-270892-ycc3csyh	115	11	concentrations	concentration	NNS
cord-270892-ycc3csyh	115	12	of	of	IN
cord-270892-ycc3csyh	115	13	IL-6	IL-6	NNP
cord-270892-ycc3csyh	115	14	and	and	CC
cord-270892-ycc3csyh	115	15	IL-8	IL-8	NNP
cord-270892-ycc3csyh	115	16	in	in	IN
cord-270892-ycc3csyh	115	17	nasal	nasal	JJ
cord-270892-ycc3csyh	115	18	secretions	secretion	NNS
cord-270892-ycc3csyh	115	19	and	and	CC
cord-270892-ycc3csyh	115	20	the	the	DT
cord-270892-ycc3csyh	115	21	severity	severity	NN
cord-270892-ycc3csyh	115	22	of	of	IN
cord-270892-ycc3csyh	115	23	symptoms	symptom	NNS
cord-270892-ycc3csyh	115	24	in	in	IN
cord-270892-ycc3csyh	115	25	upper	upper	JJ
cord-270892-ycc3csyh	115	26	and	and	CC
cord-270892-ycc3csyh	115	27	lower	low	JJR
cord-270892-ycc3csyh	115	28	HRV	HRV	NNP
cord-270892-ycc3csyh	115	29	-	-	HYPH
cord-270892-ycc3csyh	115	30	induced	induce	VBN
cord-270892-ycc3csyh	115	31	respiratory	respiratory	JJ
cord-270892-ycc3csyh	115	32	tract	tract	NN
cord-270892-ycc3csyh	115	33	disease	disease	NN
cord-270892-ycc3csyh	115	34	.	.	.
cord-270892-ycc3csyh	116	1	78	78	CD
cord-270892-ycc3csyh	116	2	,	,	,
cord-270892-ycc3csyh	116	3	83	83	CD
cord-270892-ycc3csyh	117	1	On	on	IN
cord-270892-ycc3csyh	117	2	day	day	NN
cord-270892-ycc3csyh	117	3	2	2	CD
cord-270892-ycc3csyh	117	4	-	-	SYM
cord-270892-ycc3csyh	117	5	4	4	CD
cord-270892-ycc3csyh	117	6	after	after	IN
cord-270892-ycc3csyh	117	7	virus	virus	NN
cord-270892-ycc3csyh	117	8	challenge	challenge	NN
cord-270892-ycc3csyh	117	9	,	,	,
cord-270892-ycc3csyh	117	10	IL-6	IL-6	NNP
cord-270892-ycc3csyh	117	11	and	and	CC
cord-270892-ycc3csyh	117	12	IL-8	IL-8	NNP
cord-270892-ycc3csyh	117	13	concentrations	concentration	NNS
cord-270892-ycc3csyh	117	14	were	be	VBD
cord-270892-ycc3csyh	117	15	significantly	significantly	RB
cord-270892-ycc3csyh	117	16	greater	great	JJR
cord-270892-ycc3csyh	117	17	in	in	IN
cord-270892-ycc3csyh	117	18	nasal	nasal	JJ
cord-270892-ycc3csyh	117	19	secretions	secretion	NNS
cord-270892-ycc3csyh	117	20	from	from	IN
cord-270892-ycc3csyh	117	21	experimentally	experimentally	RB
cord-270892-ycc3csyh	117	22	infected	infect	VBN
cord-270892-ycc3csyh	117	23	symptomatic	symptomatic	JJ
cord-270892-ycc3csyh	117	24	subjects	subject	NNS
cord-270892-ycc3csyh	117	25	than	than	IN
cord-270892-ycc3csyh	117	26	in	in	IN
cord-270892-ycc3csyh	117	27	those	those	DT
cord-270892-ycc3csyh	117	28	from	from	IN
cord-270892-ycc3csyh	117	29	infected	infected	JJ
cord-270892-ycc3csyh	117	30	asymptomatic	asymptomatic	JJ
cord-270892-ycc3csyh	117	31	or	or	CC
cord-270892-ycc3csyh	117	32	sham	sham	JJ
cord-270892-ycc3csyh	117	33	-	-	HYPH
cord-270892-ycc3csyh	117	34	challenged	challenge	VBN
cord-270892-ycc3csyh	117	35	subjects	subject	NNS
cord-270892-ycc3csyh	117	36	.	.	.
cord-270892-ycc3csyh	118	1	IL-8	IL-8	NNP
cord-270892-ycc3csyh	118	2	has	have	VBZ
cord-270892-ycc3csyh	118	3	been	be	VBN
cord-270892-ycc3csyh	118	4	proposed	propose	VBN
cord-270892-ycc3csyh	118	5	as	as	IN
cord-270892-ycc3csyh	118	6	a	a	DT
cord-270892-ycc3csyh	118	7	mediator	mediator	NN
cord-270892-ycc3csyh	118	8	of	of	IN
cord-270892-ycc3csyh	118	9	neutrophile	neutrophile	JJ
cord-270892-ycc3csyh	118	10	infiltrations	infiltration	NNS
cord-270892-ycc3csyh	118	11	that	that	WDT
cord-270892-ycc3csyh	118	12	are	be	VBP
cord-270892-ycc3csyh	118	13	observed	observe	VBN
cord-270892-ycc3csyh	118	14	during	during	IN
cord-270892-ycc3csyh	118	15	symptomatic	symptomatic	JJ
cord-270892-ycc3csyh	118	16	infections	infection	NNS
cord-270892-ycc3csyh	118	17	.	.	.
cord-270892-ycc3csyh	119	1	In	in	IN
cord-270892-ycc3csyh	119	2	experimental	experimental	JJ
cord-270892-ycc3csyh	119	3	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	119	4	infection	infection	NN
cord-270892-ycc3csyh	119	5	the	the	DT
cord-270892-ycc3csyh	119	6	onset	onset	NN
cord-270892-ycc3csyh	119	7	of	of	IN
cord-270892-ycc3csyh	119	8	symptoms	symptom	NNS
cord-270892-ycc3csyh	119	9	e.g.	e.g.	IN
cord-270892-ycc3csyh	119	10	nasal	nasal	JJ
cord-270892-ycc3csyh	119	11	stuffiness	stuffiness	NN
cord-270892-ycc3csyh	119	12	and	and	CC
cord-270892-ycc3csyh	119	13	discharge	discharge	NN
cord-270892-ycc3csyh	119	14	,	,	,
cord-270892-ycc3csyh	119	15	sneezing	sneezing	NN
cord-270892-ycc3csyh	119	16	,	,	,
cord-270892-ycc3csyh	119	17	and	and	CC
cord-270892-ycc3csyh	119	18	cough	cough	NN
cord-270892-ycc3csyh	119	19	was	be	VBD
cord-270892-ycc3csyh	119	20	observed	observe	VBN
cord-270892-ycc3csyh	119	21	10	10	CD
cord-270892-ycc3csyh	119	22	-	-	SYM
cord-270892-ycc3csyh	119	23	12	12	CD
cord-270892-ycc3csyh	119	24	hr	hr	NN
cord-270892-ycc3csyh	119	25	after	after	IN
cord-270892-ycc3csyh	119	26	intranasal	intranasal	NN
cord-270892-ycc3csyh	119	27	inoculation	inoculation	NN
cord-270892-ycc3csyh	119	28	of	of	IN
cord-270892-ycc3csyh	119	29	the	the	DT
cord-270892-ycc3csyh	119	30	virus	virus	NN
cord-270892-ycc3csyh	119	31	.	.	.
cord-270892-ycc3csyh	120	1	76	76	CD
cord-270892-ycc3csyh	121	1	In	in	IN
cord-270892-ycc3csyh	121	2	contrast	contrast	NN
cord-270892-ycc3csyh	121	3	to	to	IN
cord-270892-ycc3csyh	121	4	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	121	5	infections	infection	NNS
cord-270892-ycc3csyh	121	6	in	in	IN
cord-270892-ycc3csyh	121	7	adults	adult	NNS
cord-270892-ycc3csyh	121	8	,	,	,
cord-270892-ycc3csyh	121	9	fever	fever	NN
cord-270892-ycc3csyh	121	10	is	be	VBZ
cord-270892-ycc3csyh	121	11	found	find	VBN
cord-270892-ycc3csyh	121	12	in	in	IN
cord-270892-ycc3csyh	121	13	15	15	CD
cord-270892-ycc3csyh	121	14	%	%	NN
cord-270892-ycc3csyh	121	15	of	of	IN
cord-270892-ycc3csyh	121	16	children	child	NNS
cord-270892-ycc3csyh	121	17	with	with	IN
cord-270892-ycc3csyh	121	18	upper	upper	JJ
cord-270892-ycc3csyh	121	19	respiratory	respiratory	JJ
cord-270892-ycc3csyh	121	20	tract	tract	NN
cord-270892-ycc3csyh	121	21	infections	infection	NNS
cord-270892-ycc3csyh	121	22	.	.	.
cord-270892-ycc3csyh	122	1	84	84	CD
cord-270892-ycc3csyh	122	2	Other	other	JJ
cord-270892-ycc3csyh	122	3	symptoms	symptom	NNS
cord-270892-ycc3csyh	122	4	in	in	IN
cord-270892-ycc3csyh	122	5	children	child	NNS
cord-270892-ycc3csyh	122	6	and	and	CC
cord-270892-ycc3csyh	122	7	adults	adult	NNS
cord-270892-ycc3csyh	122	8	may	may	MD
cord-270892-ycc3csyh	122	9	be	be	VB
cord-270892-ycc3csyh	122	10	hoarseness	hoarseness	NN
cord-270892-ycc3csyh	122	11	,	,	,
cord-270892-ycc3csyh	122	12	headache	headache	NN
cord-270892-ycc3csyh	122	13	,	,	,
cord-270892-ycc3csyh	122	14	malaise	malaise	NN
cord-270892-ycc3csyh	122	15	,	,	,
cord-270892-ycc3csyh	122	16	and	and	CC
cord-270892-ycc3csyh	122	17	lethargy	lethargy	NN
cord-270892-ycc3csyh	122	18	.	.	.
cord-270892-ycc3csyh	123	1	Sometimes	sometimes	RB
cord-270892-ycc3csyh	123	2	viral	viral	JJ
cord-270892-ycc3csyh	123	3	infection	infection	NN
cord-270892-ycc3csyh	123	4	is	be	VBZ
cord-270892-ycc3csyh	123	5	accompanied	accompany	VBN
cord-270892-ycc3csyh	123	6	by	by	IN
cord-270892-ycc3csyh	123	7	bacterial	bacterial	JJ
cord-270892-ycc3csyh	123	8	complication	complication	NN
cord-270892-ycc3csyh	123	9	,	,	,
cord-270892-ycc3csyh	123	10	leading	lead	VBG
cord-270892-ycc3csyh	123	11	for	for	IN
cord-270892-ycc3csyh	123	12	instance	instance	NN
cord-270892-ycc3csyh	123	13	to	to	IN
cord-270892-ycc3csyh	123	14	acute	acute	JJ
cord-270892-ycc3csyh	123	15	otitis	otitis	NN
cord-270892-ycc3csyh	123	16	media	medium	NNS
cord-270892-ycc3csyh	123	17	in	in	IN
cord-270892-ycc3csyh	123	18	about	about	RB
cord-270892-ycc3csyh	123	19	20	20	CD
cord-270892-ycc3csyh	123	20	%	%	NN
cord-270892-ycc3csyh	123	21	of	of	IN
cord-270892-ycc3csyh	123	22	infected	infected	JJ
cord-270892-ycc3csyh	123	23	children	child	NNS
cord-270892-ycc3csyh	123	24	,	,	,
cord-270892-ycc3csyh	123	25	sinusitis	sinusitis	NN
cord-270892-ycc3csyh	123	26	,	,	,
cord-270892-ycc3csyh	123	27	and	and	CC
cord-270892-ycc3csyh	123	28	pneumonia	pneumonia	NN
cord-270892-ycc3csyh	123	29	.	.	.
cord-270892-ycc3csyh	124	1	[	[	-LRB-
cord-270892-ycc3csyh	124	2	79	79	CD
cord-270892-ycc3csyh	124	3	]	]	-RRB-
cord-270892-ycc3csyh	124	4	[	[	-LRB-
cord-270892-ycc3csyh	124	5	80	80	CD
cord-270892-ycc3csyh	124	6	]	]	-RRB-
cord-270892-ycc3csyh	125	1	[	[	-LRB-
cord-270892-ycc3csyh	125	2	81	81	CD
cord-270892-ycc3csyh	125	3	]	]	-RRB-
cord-270892-ycc3csyh	125	4	85	85	CD
cord-270892-ycc3csyh	125	5	,	,	,
cord-270892-ycc3csyh	125	6	86	86	CD
cord-270892-ycc3csyh	125	7	Experimental	experimental	JJ
cord-270892-ycc3csyh	125	8	infection	infection	NN
cord-270892-ycc3csyh	125	9	was	be	VBD
cord-270892-ycc3csyh	125	10	also	also	RB
cord-270892-ycc3csyh	125	11	used	use	VBN
cord-270892-ycc3csyh	125	12	to	to	TO
cord-270892-ycc3csyh	125	13	study	study	VB
cord-270892-ycc3csyh	125	14	the	the	DT
cord-270892-ycc3csyh	125	15	causation	causation	NN
cord-270892-ycc3csyh	125	16	between	between	IN
cord-270892-ycc3csyh	125	17	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	125	18	infection	infection	NN
cord-270892-ycc3csyh	125	19	and	and	CC
cord-270892-ycc3csyh	125	20	asthma	asthma	NN
cord-270892-ycc3csyh	125	21	as	as	RB
cord-270892-ycc3csyh	125	22	well	well	RB
cord-270892-ycc3csyh	125	23	as	as	IN
cord-270892-ycc3csyh	125	24	COPD	COPD	NNP
cord-270892-ycc3csyh	125	25	exacerbations	exacerbation	NNS
cord-270892-ycc3csyh	125	26	.	.	.
cord-270892-ycc3csyh	126	1	78	78	CD
cord-270892-ycc3csyh	126	2	,	,	,
cord-270892-ycc3csyh	126	3	[	[	-LRB-
cord-270892-ycc3csyh	126	4	87	87	CD
cord-270892-ycc3csyh	126	5	]	]	-RRB-
cord-270892-ycc3csyh	126	6	[	[	-LRB-
cord-270892-ycc3csyh	126	7	88	88	CD
cord-270892-ycc3csyh	126	8	]	]	-RRB-
cord-270892-ycc3csyh	127	1	[	[	-LRB-
cord-270892-ycc3csyh	127	2	89	89	CD
cord-270892-ycc3csyh	127	3	]	]	-RRB-
cord-270892-ycc3csyh	128	1	[	[	-LRB-
cord-270892-ycc3csyh	128	2	90	90	CD
cord-270892-ycc3csyh	128	3	]	]	-RRB-
cord-270892-ycc3csyh	128	4	[	[	-LRB-
cord-270892-ycc3csyh	128	5	91	91	CD
cord-270892-ycc3csyh	128	6	]	]	-RRB-
cord-270892-ycc3csyh	128	7	[	[	-LRB-
cord-270892-ycc3csyh	128	8	92	92	CD
cord-270892-ycc3csyh	128	9	]	]	-RRB-
cord-270892-ycc3csyh	129	1	[	[	-LRB-
cord-270892-ycc3csyh	129	2	93	93	CD
cord-270892-ycc3csyh	129	3	]	]	-RRB-
cord-270892-ycc3csyh	130	1	It	-PRON-	PRP
cord-270892-ycc3csyh	130	2	was	be	VBD
cord-270892-ycc3csyh	130	3	shown	show	VBN
cord-270892-ycc3csyh	130	4	that	that	IN
cord-270892-ycc3csyh	130	5	HRV	HRV	NNP
cord-270892-ycc3csyh	130	6	infection	infection	NN
cord-270892-ycc3csyh	130	7	enhances	enhance	VBZ
cord-270892-ycc3csyh	130	8	airway	airway	NN
cord-270892-ycc3csyh	130	9	reactivity	reactivity	NN
cord-270892-ycc3csyh	130	10	and	and	CC
cord-270892-ycc3csyh	130	11	predisposes	predispose	VBZ
cord-270892-ycc3csyh	130	12	allergic	allergic	JJ
cord-270892-ycc3csyh	130	13	patients	patient	NNS
cord-270892-ycc3csyh	130	14	to	to	TO
cord-270892-ycc3csyh	130	15	develop	develop	VB
cord-270892-ycc3csyh	130	16	late	late	JJ
cord-270892-ycc3csyh	130	17	asthmatic	asthmatic	JJ
cord-270892-ycc3csyh	130	18	reactions	reaction	NNS
cord-270892-ycc3csyh	130	19	.	.	.
cord-270892-ycc3csyh	131	1	88	88	CD
cord-270892-ycc3csyh	131	2	,	,	,
cord-270892-ycc3csyh	131	3	91	91	CD
cord-270892-ycc3csyh	131	4	Rhinoviral	Rhinoviral	NNP
cord-270892-ycc3csyh	131	5	colds	cold	NNS
cord-270892-ycc3csyh	131	6	were	be	VBD
cord-270892-ycc3csyh	131	7	associated	associate	VBN
cord-270892-ycc3csyh	131	8	with	with	IN
cord-270892-ycc3csyh	131	9	an	an	DT
cord-270892-ycc3csyh	131	10	increase	increase	NN
cord-270892-ycc3csyh	131	11	in	in	IN
cord-270892-ycc3csyh	131	12	histamine	histamine	NN
cord-270892-ycc3csyh	131	13	responsiveness	responsiveness	NN
cord-270892-ycc3csyh	131	14	that	that	WDT
cord-270892-ycc3csyh	131	15	was	be	VBD
cord-270892-ycc3csyh	131	16	accompanied	accompany	VBN
cord-270892-ycc3csyh	131	17	by	by	IN
cord-270892-ycc3csyh	131	18	a	a	DT
cord-270892-ycc3csyh	131	19	bronchial	bronchial	JJ
cord-270892-ycc3csyh	131	20	mucosal	mucosal	NN
cord-270892-ycc3csyh	131	21	lymphocytic	lymphocytic	JJ
cord-270892-ycc3csyh	131	22	and	and	CC
cord-270892-ycc3csyh	131	23	eosinophilic	eosinophilic	JJ
cord-270892-ycc3csyh	131	24	infiltrate	infiltrate	NN
cord-270892-ycc3csyh	131	25	.	.	.
cord-270892-ycc3csyh	132	1	89	89	CD
cord-270892-ycc3csyh	133	1	In	in	IN
cord-270892-ycc3csyh	133	2	a	a	DT
cord-270892-ycc3csyh	133	3	recent	recent	JJ
cord-270892-ycc3csyh	133	4	study	study	NN
cord-270892-ycc3csyh	133	5	,	,	,
cord-270892-ycc3csyh	133	6	an	an	DT
cord-270892-ycc3csyh	133	7	increased	increase	VBN
cord-270892-ycc3csyh	133	8	HRV	HRV	NNP
cord-270892-ycc3csyh	133	9	-	-	HYPH
cord-270892-ycc3csyh	133	10	induced	induce	VBN
cord-270892-ycc3csyh	133	11	clinical	clinical	JJ
cord-270892-ycc3csyh	133	12	illness	illness	NN
cord-270892-ycc3csyh	133	13	severity	severity	NN
cord-270892-ycc3csyh	133	14	in	in	IN
cord-270892-ycc3csyh	133	15	asthmatic	asthmatic	JJ
cord-270892-ycc3csyh	133	16	compared	compare	VBN
cord-270892-ycc3csyh	133	17	with	with	IN
cord-270892-ycc3csyh	133	18	normal	normal	JJ
cord-270892-ycc3csyh	133	19	subjects	subject	NNS
cord-270892-ycc3csyh	133	20	was	be	VBD
cord-270892-ycc3csyh	133	21	demonstrated	demonstrate	VBN
cord-270892-ycc3csyh	133	22	.	.	.
cord-270892-ycc3csyh	134	1	93	93	CD
cord-270892-ycc3csyh	135	1	Strong	strong	JJ
cord-270892-ycc3csyh	135	2	relationships	relationship	NNS
cord-270892-ycc3csyh	135	3	were	be	VBD
cord-270892-ycc3csyh	135	4	shown	show	VBN
cord-270892-ycc3csyh	135	5	between	between	IN
cord-270892-ycc3csyh	135	6	virus	virus	NN
cord-270892-ycc3csyh	135	7	load	load	NN
cord-270892-ycc3csyh	135	8	,	,	,
cord-270892-ycc3csyh	135	9	lower	low	JJR
cord-270892-ycc3csyh	135	10	airway	airway	NN
cord-270892-ycc3csyh	135	11	virus	virus	NN
cord-270892-ycc3csyh	135	12	-	-	HYPH
cord-270892-ycc3csyh	135	13	induced	induce	VBN
cord-270892-ycc3csyh	135	14	inflammation	inflammation	NN
cord-270892-ycc3csyh	135	15	,	,	,
cord-270892-ycc3csyh	135	16	and	and	CC
cord-270892-ycc3csyh	135	17	asthma	asthma	NN
cord-270892-ycc3csyh	135	18	exacerbation	exacerbation	NN
cord-270892-ycc3csyh	135	19	severity	severity	NN
cord-270892-ycc3csyh	135	20	.	.	.
cord-270892-ycc3csyh	136	1	The	the	DT
cord-270892-ycc3csyh	136	2	results	result	NNS
cord-270892-ycc3csyh	136	3	of	of	IN
cord-270892-ycc3csyh	136	4	this	this	DT
cord-270892-ycc3csyh	136	5	study	study	NN
cord-270892-ycc3csyh	136	6	also	also	RB
cord-270892-ycc3csyh	136	7	indicated	indicate	VBD
cord-270892-ycc3csyh	136	8	that	that	IN
cord-270892-ycc3csyh	136	9	augmented	augment	VBN
cord-270892-ycc3csyh	136	10	Th2	th2	CD
cord-270892-ycc3csyh	136	11	or	or	CC
cord-270892-ycc3csyh	136	12	impaired	impair	VBN
cord-270892-ycc3csyh	136	13	Th1	th1	CD
cord-270892-ycc3csyh	136	14	or	or	CC
cord-270892-ycc3csyh	136	15	IL-10	IL-10	NNP
cord-270892-ycc3csyh	136	16	immunity	immunity	NN
cord-270892-ycc3csyh	136	17	are	be	VBP
cord-270892-ycc3csyh	136	18	likely	likely	RB
cord-270892-ycc3csyh	136	19	important	important	JJ
cord-270892-ycc3csyh	136	20	mechanisms	mechanism	NNS
cord-270892-ycc3csyh	136	21	.	.	.
cord-270892-ycc3csyh	137	1	Mallia	Mallia	NNP
cord-270892-ycc3csyh	137	2	et	et	NNP
cord-270892-ycc3csyh	137	3	al	al	NNP
cord-270892-ycc3csyh	137	4	.	.	.
cord-270892-ycc3csyh	138	1	provided	provide	VBN
cord-270892-ycc3csyh	138	2	evidence	evidence	NN
cord-270892-ycc3csyh	138	3	that	that	IN
cord-270892-ycc3csyh	138	4	low	low	JJ
cord-270892-ycc3csyh	138	5	dose	dose	NN
cord-270892-ycc3csyh	138	6	experimental	experimental	JJ
cord-270892-ycc3csyh	138	7	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	138	8	infection	infection	NN
cord-270892-ycc3csyh	138	9	in	in	IN
cord-270892-ycc3csyh	138	10	patients	patient	NNS
cord-270892-ycc3csyh	138	11	with	with	IN
cord-270892-ycc3csyh	138	12	COPD	COPD	NNP
cord-270892-ycc3csyh	138	13	induces	induce	VBZ
cord-270892-ycc3csyh	138	14	symptoms	symptom	NNS
cord-270892-ycc3csyh	138	15	and	and	CC
cord-270892-ycc3csyh	138	16	lung	lung	NN
cord-270892-ycc3csyh	138	17	function	function	NN
cord-270892-ycc3csyh	138	18	changes	change	VBZ
cord-270892-ycc3csyh	138	19	typical	typical	JJ
cord-270892-ycc3csyh	138	20	of	of	IN
cord-270892-ycc3csyh	138	21	an	an	DT
cord-270892-ycc3csyh	138	22	acute	acute	JJ
cord-270892-ycc3csyh	138	23	exacerbation	exacerbation	NN
cord-270892-ycc3csyh	138	24	of	of	IN
cord-270892-ycc3csyh	138	25	COPD	COPD	NNP
cord-270892-ycc3csyh	138	26	.	.	.
cord-270892-ycc3csyh	139	1	92	92	CD
cord-270892-ycc3csyh	139	2	Viral	viral	JJ
cord-270892-ycc3csyh	139	3	replication	replication	NN
cord-270892-ycc3csyh	139	4	and	and	CC
cord-270892-ycc3csyh	139	5	increased	increase	VBN
cord-270892-ycc3csyh	139	6	pro	pro	JJ
cord-270892-ycc3csyh	139	7	-	-	JJ
cord-270892-ycc3csyh	139	8	inflammatory	inflammatory	JJ
cord-270892-ycc3csyh	139	9	cytokine	cytokine	NN
cord-270892-ycc3csyh	139	10	response	response	NN
cord-270892-ycc3csyh	139	11	were	be	VBD
cord-270892-ycc3csyh	139	12	associated	associate	VBN
cord-270892-ycc3csyh	139	13	with	with	IN
cord-270892-ycc3csyh	139	14	symptomatic	symptomatic	JJ
cord-270892-ycc3csyh	139	15	colds	cold	NNS
cord-270892-ycc3csyh	139	16	,	,	,
cord-270892-ycc3csyh	139	17	increases	increase	NNS
cord-270892-ycc3csyh	139	18	in	in	IN
cord-270892-ycc3csyh	139	19	lower	low	JJR
cord-270892-ycc3csyh	139	20	respiratory	respiratory	JJ
cord-270892-ycc3csyh	139	21	tract	tract	NN
cord-270892-ycc3csyh	139	22	symptoms	symptom	NNS
cord-270892-ycc3csyh	139	23	and	and	CC
cord-270892-ycc3csyh	139	24	reductions	reduction	NNS
cord-270892-ycc3csyh	139	25	in	in	IN
cord-270892-ycc3csyh	139	26	forced	force	VBN
cord-270892-ycc3csyh	139	27	expiratory	expiratory	JJ
cord-270892-ycc3csyh	139	28	volume	volume	NN
cord-270892-ycc3csyh	139	29	in	in	IN
cord-270892-ycc3csyh	139	30	1s	1s	CD
cord-270892-ycc3csyh	139	31	or	or	CC
cord-270892-ycc3csyh	139	32	peak	peak	NN
cord-270892-ycc3csyh	139	33	expiratory	expiratory	JJ
cord-270892-ycc3csyh	139	34	flow	flow	NN
cord-270892-ycc3csyh	139	35	rate	rate	NN
cord-270892-ycc3csyh	139	36	.	.	.
cord-270892-ycc3csyh	140	1	The	the	DT
cord-270892-ycc3csyh	140	2	epidemiological	epidemiological	JJ
cord-270892-ycc3csyh	140	3	data	datum	NNS
cord-270892-ycc3csyh	140	4	and	and	CC
cord-270892-ycc3csyh	140	5	pathology	pathology	NN
cord-270892-ycc3csyh	140	6	of	of	IN
cord-270892-ycc3csyh	140	7	HRV	HRV	NNP
cord-270892-ycc3csyh	140	8	infections	infection	NNS
cord-270892-ycc3csyh	140	9	explain	explain	VBP
cord-270892-ycc3csyh	140	10	their	-PRON-	PRP$
cord-270892-ycc3csyh	140	11	high	high	JJ
cord-270892-ycc3csyh	140	12	medical	medical	JJ
cord-270892-ycc3csyh	140	13	and	and	CC
cord-270892-ycc3csyh	140	14	socio	socio	JJ
cord-270892-ycc3csyh	140	15	-	-	HYPH
cord-270892-ycc3csyh	140	16	economic	economic	JJ
cord-270892-ycc3csyh	140	17	impact	impact	NN
cord-270892-ycc3csyh	140	18	.	.	.
cord-270892-ycc3csyh	141	1	Millions	million	NNS
cord-270892-ycc3csyh	141	2	of	of	IN
cord-270892-ycc3csyh	141	3	children	child	NNS
cord-270892-ycc3csyh	141	4	and	and	CC
cord-270892-ycc3csyh	141	5	adults	adult	NNS
cord-270892-ycc3csyh	141	6	are	be	VBP
cord-270892-ycc3csyh	141	7	taken	take	VBN
cord-270892-ycc3csyh	141	8	ill	ill	RB
cord-270892-ycc3csyh	141	9	with	with	IN
cord-270892-ycc3csyh	141	10	common	common	JJ
cord-270892-ycc3csyh	141	11	cold	cold	NN
cord-270892-ycc3csyh	141	12	every	every	DT
cord-270892-ycc3csyh	141	13	year	year	NN
cord-270892-ycc3csyh	141	14	,	,	,
cord-270892-ycc3csyh	141	15	need	need	VB
cord-270892-ycc3csyh	141	16	medical	medical	JJ
cord-270892-ycc3csyh	141	17	consultations	consultation	NNS
cord-270892-ycc3csyh	141	18	,	,	,
cord-270892-ycc3csyh	141	19	are	be	VBP
cord-270892-ycc3csyh	141	20	unable	unable	JJ
cord-270892-ycc3csyh	141	21	to	to	TO
cord-270892-ycc3csyh	141	22	attend	attend	VB
cord-270892-ycc3csyh	141	23	school	school	NN
cord-270892-ycc3csyh	141	24	and	and	CC
cord-270892-ycc3csyh	141	25	go	go	VB
cord-270892-ycc3csyh	141	26	to	to	IN
cord-270892-ycc3csyh	141	27	work	work	NN
cord-270892-ycc3csyh	141	28	.	.	.
cord-270892-ycc3csyh	142	1	94	94	CD
cord-270892-ycc3csyh	142	2	,	,	,
cord-270892-ycc3csyh	142	3	95	95	CD
cord-270892-ycc3csyh	142	4	Direct	direct	JJ
cord-270892-ycc3csyh	142	5	costs	cost	NNS
cord-270892-ycc3csyh	142	6	include	include	VBP
cord-270892-ycc3csyh	142	7	hospitalization	hospitalization	NN
cord-270892-ycc3csyh	142	8	,	,	,
cord-270892-ycc3csyh	142	9	medical	medical	JJ
cord-270892-ycc3csyh	142	10	fees	fee	NNS
cord-270892-ycc3csyh	142	11	,	,	,
cord-270892-ycc3csyh	142	12	and	and	CC
cord-270892-ycc3csyh	142	13	symptomatic	symptomatic	JJ
cord-270892-ycc3csyh	142	14	treatment	treatment	NN
cord-270892-ycc3csyh	142	15	.	.	.
cord-270892-ycc3csyh	143	1	Moreover	moreover	RB
cord-270892-ycc3csyh	143	2	,	,	,
cord-270892-ycc3csyh	143	3	exacerbations	exacerbation	NNS
cord-270892-ycc3csyh	143	4	are	be	VBP
cord-270892-ycc3csyh	143	5	the	the	DT
cord-270892-ycc3csyh	143	6	major	major	JJ
cord-270892-ycc3csyh	143	7	cause	cause	NN
cord-270892-ycc3csyh	143	8	of	of	IN
cord-270892-ycc3csyh	143	9	asthma	asthma	NN
cord-270892-ycc3csyh	143	10	and	and	CC
cord-270892-ycc3csyh	143	11	COPD	COPD	NNP
cord-270892-ycc3csyh	143	12	morbidity	morbidity	NN
cord-270892-ycc3csyh	143	13	,	,	,
cord-270892-ycc3csyh	143	14	mortality	mortality	NN
cord-270892-ycc3csyh	143	15	,	,	,
cord-270892-ycc3csyh	143	16	and	and	CC
cord-270892-ycc3csyh	143	17	health	health	NN
cord-270892-ycc3csyh	143	18	care	care	NN
cord-270892-ycc3csyh	143	19	costs	cost	NNS
cord-270892-ycc3csyh	143	20	associated	associate	VBN
cord-270892-ycc3csyh	143	21	with	with	IN
cord-270892-ycc3csyh	143	22	these	these	DT
cord-270892-ycc3csyh	143	23	diseases	disease	NNS
cord-270892-ycc3csyh	143	24	.	.	.
cord-270892-ycc3csyh	144	1	92	92	CD
cord-270892-ycc3csyh	144	2	,	,	,
cord-270892-ycc3csyh	144	3	93	93	CD
cord-270892-ycc3csyh	145	1	To	to	IN
cord-270892-ycc3csyh	145	2	date	date	NN
cord-270892-ycc3csyh	145	3	,	,	,
cord-270892-ycc3csyh	145	4	specific	specific	JJ
cord-270892-ycc3csyh	145	5	drugs	drug	NNS
cord-270892-ycc3csyh	145	6	that	that	WDT
cord-270892-ycc3csyh	145	7	prevent	prevent	VBP
cord-270892-ycc3csyh	145	8	or	or	CC
cord-270892-ycc3csyh	145	9	reduce	reduce	VB
cord-270892-ycc3csyh	145	10	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	145	11	infection	infection	NN
cord-270892-ycc3csyh	145	12	are	be	VBP
cord-270892-ycc3csyh	145	13	not	not	RB
cord-270892-ycc3csyh	145	14	available	available	JJ
cord-270892-ycc3csyh	145	15	.	.	.
cord-270892-ycc3csyh	146	1	Common	common	JJ
cord-270892-ycc3csyh	146	2	cold	cold	NN
cord-270892-ycc3csyh	146	3	can	can	MD
cord-270892-ycc3csyh	146	4	be	be	VB
cord-270892-ycc3csyh	146	5	treated	treat	VBN
cord-270892-ycc3csyh	146	6	only	only	RB
cord-270892-ycc3csyh	146	7	symptomatically	symptomatically	RB
cord-270892-ycc3csyh	146	8	with	with	IN
cord-270892-ycc3csyh	146	9	analgesics	analgesic	NNS
cord-270892-ycc3csyh	146	10	,	,	,
cord-270892-ycc3csyh	146	11	decongestants	decongestant	NNS
cord-270892-ycc3csyh	146	12	,	,	,
cord-270892-ycc3csyh	146	13	antihistamines	antihistamine	NNS
cord-270892-ycc3csyh	146	14	,	,	,
cord-270892-ycc3csyh	146	15	or	or	CC
cord-270892-ycc3csyh	146	16	antitussives	antitussive	NNS
cord-270892-ycc3csyh	146	17	and	and	CC
cord-270892-ycc3csyh	146	18	antibiotics	antibiotic	NNS
cord-270892-ycc3csyh	146	19	are	be	VBP
cord-270892-ycc3csyh	146	20	often	often	RB
cord-270892-ycc3csyh	146	21	wrongly	wrongly	RB
cord-270892-ycc3csyh	146	22	prescribed	prescribe	VBN
cord-270892-ycc3csyh	146	23	.	.	.
cord-270892-ycc3csyh	147	1	96	96	CD
cord-270892-ycc3csyh	147	2	,	,	,
cord-270892-ycc3csyh	147	3	97	97	CD
cord-270892-ycc3csyh	148	1	Because	because	IN
cord-270892-ycc3csyh	148	2	of	of	IN
cord-270892-ycc3csyh	148	3	the	the	DT
cord-270892-ycc3csyh	148	4	large	large	JJ
cord-270892-ycc3csyh	148	5	number	number	NN
cord-270892-ycc3csyh	148	6	of	of	IN
cord-270892-ycc3csyh	148	7	circulating	circulate	VBG
cord-270892-ycc3csyh	148	8	HRV	HRV	NNP
cord-270892-ycc3csyh	148	9	serotypes	serotype	NNS
cord-270892-ycc3csyh	148	10	,	,	,
cord-270892-ycc3csyh	148	11	treatment	treatment	NN
cord-270892-ycc3csyh	148	12	with	with	IN
cord-270892-ycc3csyh	148	13	specific	specific	JJ
cord-270892-ycc3csyh	148	14	antiviral	antiviral	JJ
cord-270892-ycc3csyh	148	15	drugs	drug	NNS
cord-270892-ycc3csyh	148	16	is	be	VBZ
cord-270892-ycc3csyh	148	17	considered	consider	VBN
cord-270892-ycc3csyh	148	18	to	to	TO
cord-270892-ycc3csyh	148	19	be	be	VB
cord-270892-ycc3csyh	148	20	more	more	RBR
cord-270892-ycc3csyh	148	21	striking	striking	JJ
cord-270892-ycc3csyh	148	22	than	than	IN
cord-270892-ycc3csyh	148	23	vaccination	vaccination	NN
cord-270892-ycc3csyh	148	24	.	.	.
cord-270892-ycc3csyh	149	1	Therefore	therefore	RB
cord-270892-ycc3csyh	149	2	,	,	,
cord-270892-ycc3csyh	149	3	the	the	DT
cord-270892-ycc3csyh	149	4	search	search	NN
cord-270892-ycc3csyh	149	5	for	for	IN
cord-270892-ycc3csyh	149	6	new	new	JJ
cord-270892-ycc3csyh	149	7	highly	highly	RB
cord-270892-ycc3csyh	149	8	active	active	JJ
cord-270892-ycc3csyh	149	9	synthetic	synthetic	NN
cord-270892-ycc3csyh	149	10	and/or	and/or	CC
cord-270892-ycc3csyh	149	11	natural	natural	JJ
cord-270892-ycc3csyh	149	12	anti	anti	JJ
cord-270892-ycc3csyh	149	13	-	-	JJ
cord-270892-ycc3csyh	149	14	HRV	HRV	NNP
cord-270892-ycc3csyh	149	15	compounds	compound	NNS
cord-270892-ycc3csyh	149	16	is	be	VBZ
cord-270892-ycc3csyh	149	17	absolutely	absolutely	RB
cord-270892-ycc3csyh	149	18	essential	essential	JJ
cord-270892-ycc3csyh	149	19	and	and	CC
cord-270892-ycc3csyh	149	20	represents	represent	VBZ
cord-270892-ycc3csyh	149	21	an	an	DT
cord-270892-ycc3csyh	149	22	important	important	JJ
cord-270892-ycc3csyh	149	23	area	area	NN
cord-270892-ycc3csyh	149	24	of	of	IN
cord-270892-ycc3csyh	149	25	antiviral	antiviral	JJ
cord-270892-ycc3csyh	149	26	research	research	NN
cord-270892-ycc3csyh	149	27	.	.	.
cord-270892-ycc3csyh	150	1	Such	such	PDT
cord-270892-ycc3csyh	150	2	an	an	DT
cord-270892-ycc3csyh	150	3	anti	anti	JJ
cord-270892-ycc3csyh	150	4	-	-	JJ
cord-270892-ycc3csyh	150	5	HRV	HRV	NNP
cord-270892-ycc3csyh	150	6	drug	drug	NN
cord-270892-ycc3csyh	150	7	would	would	MD
cord-270892-ycc3csyh	150	8	have	have	VB
cord-270892-ycc3csyh	150	9	to	to	TO
cord-270892-ycc3csyh	150	10	be	be	VB
cord-270892-ycc3csyh	150	11	(	(	-LRB-
cord-270892-ycc3csyh	150	12	i	i	NN
cord-270892-ycc3csyh	150	13	)	)	-RRB-
cord-270892-ycc3csyh	150	14	with	with	IN
cord-270892-ycc3csyh	150	15	broad	broad	JJ
cord-270892-ycc3csyh	150	16	spectrum	spectrum	NN
cord-270892-ycc3csyh	150	17	activity	activity	NN
cord-270892-ycc3csyh	150	18	because	because	IN
cord-270892-ycc3csyh	150	19	of	of	IN
cord-270892-ycc3csyh	150	20	the	the	DT
cord-270892-ycc3csyh	150	21	high	high	JJ
cord-270892-ycc3csyh	150	22	number	number	NN
cord-270892-ycc3csyh	150	23	of	of	IN
cord-270892-ycc3csyh	150	24	HRV	HRV	NNP
cord-270892-ycc3csyh	150	25	serotypes	serotype	NNS
cord-270892-ycc3csyh	150	26	,	,	,
cord-270892-ycc3csyh	150	27	(	(	-LRB-
cord-270892-ycc3csyh	150	28	ii	ii	NN
cord-270892-ycc3csyh	150	29	)	)	-RRB-
cord-270892-ycc3csyh	150	30	administered	administer	VBN
cord-270892-ycc3csyh	150	31	very	very	RB
cord-270892-ycc3csyh	150	32	early	early	RB
cord-270892-ycc3csyh	150	33	in	in	IN
cord-270892-ycc3csyh	150	34	infection	infection	NN
cord-270892-ycc3csyh	150	35	to	to	TO
cord-270892-ycc3csyh	150	36	demonstrate	demonstrate	VB
cord-270892-ycc3csyh	150	37	a	a	DT
cord-270892-ycc3csyh	150	38	good	good	JJ
cord-270892-ycc3csyh	150	39	antiviral	antiviral	JJ
cord-270892-ycc3csyh	150	40	effect	effect	NN
cord-270892-ycc3csyh	150	41	because	because	IN
cord-270892-ycc3csyh	150	42	of	of	IN
cord-270892-ycc3csyh	150	43	the	the	DT
cord-270892-ycc3csyh	150	44	fast	fast	JJ
cord-270892-ycc3csyh	150	45	infection	infection	NN
cord-270892-ycc3csyh	150	46	kinetics	kinetics	NN
cord-270892-ycc3csyh	150	47	,	,	,
cord-270892-ycc3csyh	150	48	(	(	-LRB-
cord-270892-ycc3csyh	150	49	iii	iii	NN
cord-270892-ycc3csyh	150	50	)	)	-RRB-
cord-270892-ycc3csyh	150	51	very	very	RB
cord-270892-ycc3csyh	150	52	safe	safe	JJ
cord-270892-ycc3csyh	150	53	because	because	IN
cord-270892-ycc3csyh	150	54	of	of	IN
cord-270892-ycc3csyh	150	55	the	the	DT
cord-270892-ycc3csyh	150	56	broad	broad	JJ
cord-270892-ycc3csyh	150	57	application	application	NN
cord-270892-ycc3csyh	150	58	by	by	IN
cord-270892-ycc3csyh	150	59	millions	million	NNS
cord-270892-ycc3csyh	150	60	of	of	IN
cord-270892-ycc3csyh	150	61	people	people	NNS
cord-270892-ycc3csyh	150	62	,	,	,
cord-270892-ycc3csyh	150	63	and	and	CC
cord-270892-ycc3csyh	150	64	(	(	-LRB-
cord-270892-ycc3csyh	150	65	iv	iv	LS
cord-270892-ycc3csyh	150	66	)	)	-RRB-
cord-270892-ycc3csyh	150	67	directed	direct	VBN
cord-270892-ycc3csyh	150	68	against	against	IN
cord-270892-ycc3csyh	150	69	a	a	DT
cord-270892-ycc3csyh	150	70	highly	highly	RB
cord-270892-ycc3csyh	150	71	conserved	conserve	VBN
cord-270892-ycc3csyh	150	72	target	target	NN
cord-270892-ycc3csyh	150	73	with	with	IN
cord-270892-ycc3csyh	150	74	low	low	JJ
cord-270892-ycc3csyh	150	75	risk	risk	NN
cord-270892-ycc3csyh	150	76	of	of	IN
cord-270892-ycc3csyh	150	77	resistance	resistance	NN
cord-270892-ycc3csyh	150	78	development	development	NN
cord-270892-ycc3csyh	150	79	.	.	.
cord-270892-ycc3csyh	151	1	Due	due	IN
cord-270892-ycc3csyh	151	2	to	to	IN
cord-270892-ycc3csyh	151	3	the	the	DT
cord-270892-ycc3csyh	151	4	very	very	RB
cord-270892-ycc3csyh	151	5	high	high	JJ
cord-270892-ycc3csyh	151	6	error	error	NN
cord-270892-ycc3csyh	151	7	rates	rate	NNS
cord-270892-ycc3csyh	151	8	and	and	CC
cord-270892-ycc3csyh	151	9	the	the	DT
cord-270892-ycc3csyh	151	10	lack	lack	NN
cord-270892-ycc3csyh	151	11	of	of	IN
cord-270892-ycc3csyh	151	12	proofreading	proofread	VBG
cord-270892-ycc3csyh	151	13	ability	ability	NN
cord-270892-ycc3csyh	151	14	in	in	IN
cord-270892-ycc3csyh	151	15	RNA	RNA	NNP
cord-270892-ycc3csyh	151	16	polymerases	polymerase	NNS
cord-270892-ycc3csyh	151	17	of	of	IN
cord-270892-ycc3csyh	151	18	picornaviruses	picornavirus	NNS
cord-270892-ycc3csyh	151	19	,	,	,
cord-270892-ycc3csyh	151	20	98	98	CD
cord-270892-ycc3csyh	151	21	naturally	naturally	RB
cord-270892-ycc3csyh	151	22	drug	drug	NN
cord-270892-ycc3csyh	151	23	-	-	HYPH
cord-270892-ycc3csyh	151	24	resistant	resistant	JJ
cord-270892-ycc3csyh	151	25	variants	variant	NNS
cord-270892-ycc3csyh	151	26	may	may	MD
cord-270892-ycc3csyh	151	27	exist	exist	VB
cord-270892-ycc3csyh	151	28	in	in	IN
cord-270892-ycc3csyh	151	29	virus	virus	NN
cord-270892-ycc3csyh	151	30	populations	population	NNS
cord-270892-ycc3csyh	151	31	or	or	CC
cord-270892-ycc3csyh	151	32	resistant	resistant	JJ
cord-270892-ycc3csyh	151	33	viruses	virus	NNS
cord-270892-ycc3csyh	151	34	can	can	MD
cord-270892-ycc3csyh	151	35	emerge	emerge	VB
cord-270892-ycc3csyh	151	36	under	under	IN
cord-270892-ycc3csyh	151	37	treatment	treatment	NN
cord-270892-ycc3csyh	151	38	.	.	.
cord-270892-ycc3csyh	152	1	As	as	IN
cord-270892-ycc3csyh	152	2	with	with	IN
cord-270892-ycc3csyh	152	3	HIV	HIV	NNP
cord-270892-ycc3csyh	152	4	,	,	,
cord-270892-ycc3csyh	152	5	another	another	DT
cord-270892-ycc3csyh	152	6	highly	highly	RB
cord-270892-ycc3csyh	152	7	variable	variable	JJ
cord-270892-ycc3csyh	152	8	RNA	RNA	NNP
cord-270892-ycc3csyh	152	9	virus	virus	NN
cord-270892-ycc3csyh	152	10	,	,	,
cord-270892-ycc3csyh	152	11	the	the	DT
cord-270892-ycc3csyh	152	12	risk	risk	NN
cord-270892-ycc3csyh	152	13	of	of	IN
cord-270892-ycc3csyh	152	14	resistance	resistance	NN
cord-270892-ycc3csyh	152	15	development	development	NN
cord-270892-ycc3csyh	152	16	and/or	and/or	CC
cord-270892-ycc3csyh	152	17	selection	selection	NN
cord-270892-ycc3csyh	152	18	of	of	IN
cord-270892-ycc3csyh	152	19	resistant	resistant	JJ
cord-270892-ycc3csyh	152	20	virus	virus	NN
cord-270892-ycc3csyh	152	21	variants	variant	NNS
cord-270892-ycc3csyh	152	22	could	could	MD
cord-270892-ycc3csyh	152	23	be	be	VB
cord-270892-ycc3csyh	152	24	minimized	minimize	VBN
cord-270892-ycc3csyh	152	25	by	by	IN
cord-270892-ycc3csyh	152	26	applying	apply	VBG
cord-270892-ycc3csyh	152	27	combination	combination	NN
cord-270892-ycc3csyh	152	28	of	of	IN
cord-270892-ycc3csyh	152	29	drugs	drug	NNS
cord-270892-ycc3csyh	152	30	directed	direct	VBN
cord-270892-ycc3csyh	152	31	against	against	IN
cord-270892-ycc3csyh	152	32	different	different	JJ
cord-270892-ycc3csyh	152	33	targets	target	NNS
cord-270892-ycc3csyh	152	34	.	.	.
cord-270892-ycc3csyh	153	1	Because	because	IN
cord-270892-ycc3csyh	153	2	clinical	clinical	JJ
cord-270892-ycc3csyh	153	3	symptoms	symptom	NNS
cord-270892-ycc3csyh	153	4	are	be	VBP
cord-270892-ycc3csyh	153	5	suggested	suggest	VBN
cord-270892-ycc3csyh	153	6	to	to	TO
cord-270892-ycc3csyh	153	7	be	be	VB
cord-270892-ycc3csyh	153	8	primarily	primarily	RB
cord-270892-ycc3csyh	153	9	caused	cause	VBN
cord-270892-ycc3csyh	153	10	by	by	IN
cord-270892-ycc3csyh	153	11	the	the	DT
cord-270892-ycc3csyh	153	12	inflammatory	inflammatory	JJ
cord-270892-ycc3csyh	153	13	response	response	NN
cord-270892-ycc3csyh	153	14	of	of	IN
cord-270892-ycc3csyh	153	15	the	the	DT
cord-270892-ycc3csyh	153	16	host	host	NN
cord-270892-ycc3csyh	153	17	to	to	IN
cord-270892-ycc3csyh	153	18	the	the	DT
cord-270892-ycc3csyh	153	19	virus	virus	NN
cord-270892-ycc3csyh	153	20	infection	infection	NN
cord-270892-ycc3csyh	153	21	mediated	mediate	VBN
cord-270892-ycc3csyh	153	22	by	by	IN
cord-270892-ycc3csyh	153	23	specific	specific	JJ
cord-270892-ycc3csyh	153	24	cytokines	cytokine	NNS
cord-270892-ycc3csyh	153	25	,	,	,
cord-270892-ycc3csyh	153	26	a	a	DT
cord-270892-ycc3csyh	153	27	further	further	JJ
cord-270892-ycc3csyh	153	28	advantage	advantage	NN
cord-270892-ycc3csyh	153	29	of	of	IN
cord-270892-ycc3csyh	153	30	drug	drug	NN
cord-270892-ycc3csyh	153	31	combinations	combination	NNS
cord-270892-ycc3csyh	153	32	could	could	MD
cord-270892-ycc3csyh	153	33	be	be	VB
cord-270892-ycc3csyh	153	34	an	an	DT
cord-270892-ycc3csyh	153	35	additional	additional	JJ
cord-270892-ycc3csyh	153	36	immune	immune	NN
cord-270892-ycc3csyh	153	37	-	-	HYPH
cord-270892-ycc3csyh	153	38	suppressive	suppressive	JJ
cord-270892-ycc3csyh	153	39	activity	activity	NN
cord-270892-ycc3csyh	153	40	.	.	.
cord-270892-ycc3csyh	154	1	The	the	DT
cord-270892-ycc3csyh	154	2	knowledge	knowledge	NN
cord-270892-ycc3csyh	154	3	of	of	IN
cord-270892-ycc3csyh	154	4	structural	structural	JJ
cord-270892-ycc3csyh	154	5	components	component	NNS
cord-270892-ycc3csyh	154	6	,	,	,
cord-270892-ycc3csyh	154	7	nonstructural	nonstructural	JJ
cord-270892-ycc3csyh	154	8	proteins	protein	NNS
cord-270892-ycc3csyh	154	9	that	that	WDT
cord-270892-ycc3csyh	154	10	are	be	VBP
cord-270892-ycc3csyh	154	11	necessary	necessary	JJ
cord-270892-ycc3csyh	154	12	for	for	IN
cord-270892-ycc3csyh	154	13	viral	viral	JJ
cord-270892-ycc3csyh	154	14	multiplication	multiplication	NN
cord-270892-ycc3csyh	154	15	,	,	,
cord-270892-ycc3csyh	154	16	and	and	CC
cord-270892-ycc3csyh	154	17	stages	stage	NNS
cord-270892-ycc3csyh	154	18	of	of	IN
cord-270892-ycc3csyh	154	19	the	the	DT
cord-270892-ycc3csyh	154	20	viral	viral	JJ
cord-270892-ycc3csyh	154	21	life	life	NN
cord-270892-ycc3csyh	154	22	cycle	cycle	NN
cord-270892-ycc3csyh	154	23	is	be	VBZ
cord-270892-ycc3csyh	154	24	an	an	DT
cord-270892-ycc3csyh	154	25	essential	essential	JJ
cord-270892-ycc3csyh	154	26	precondition	precondition	NN
cord-270892-ycc3csyh	154	27	for	for	IN
cord-270892-ycc3csyh	154	28	the	the	DT
cord-270892-ycc3csyh	154	29	development	development	NN
cord-270892-ycc3csyh	154	30	of	of	IN
cord-270892-ycc3csyh	154	31	measures	measure	NNS
cord-270892-ycc3csyh	154	32	to	to	TO
cord-270892-ycc3csyh	154	33	prevent	prevent	VB
cord-270892-ycc3csyh	154	34	and	and	CC
cord-270892-ycc3csyh	154	35	treat	treat	VB
cord-270892-ycc3csyh	154	36	HRV	HRV	NNP
cord-270892-ycc3csyh	154	37	infection	infection	NN
cord-270892-ycc3csyh	154	38	.	.	.
cord-270892-ycc3csyh	155	1	The	the	DT
cord-270892-ycc3csyh	155	2	structure	structure	NN
cord-270892-ycc3csyh	155	3	of	of	IN
cord-270892-ycc3csyh	155	4	HRV	HRV	NNP
cord-270892-ycc3csyh	155	5	particles	particle	NNS
cord-270892-ycc3csyh	155	6	is	be	VBZ
cord-270892-ycc3csyh	155	7	well	well	RB
cord-270892-ycc3csyh	155	8	known	known	JJ
cord-270892-ycc3csyh	155	9	.	.	.
cord-270892-ycc3csyh	156	1	Infectious	infectious	JJ
cord-270892-ycc3csyh	156	2	virions	virion	NNS
cord-270892-ycc3csyh	156	3	consist	consist	VBP
cord-270892-ycc3csyh	156	4	of	of	IN
cord-270892-ycc3csyh	156	5	an	an	DT
cord-270892-ycc3csyh	156	6	icosahedral	icosahedral	JJ
cord-270892-ycc3csyh	156	7	protein	protein	NN
cord-270892-ycc3csyh	156	8	shell	shell	NN
cord-270892-ycc3csyh	156	9	(	(	-LRB-
cord-270892-ycc3csyh	156	10	capsid	capsid	NN
cord-270892-ycc3csyh	156	11	)	)	-RRB-
cord-270892-ycc3csyh	156	12	that	that	WDT
cord-270892-ycc3csyh	156	13	surrounds	surround	VBZ
cord-270892-ycc3csyh	156	14	and	and	CC
cord-270892-ycc3csyh	156	15	protects	protect	VBZ
cord-270892-ycc3csyh	156	16	the	the	DT
cord-270892-ycc3csyh	156	17	genome	genome	NN
cord-270892-ycc3csyh	156	18	,	,	,
cord-270892-ycc3csyh	156	19	a	a	DT
cord-270892-ycc3csyh	156	20	single	single	JJ
cord-270892-ycc3csyh	156	21	positive	positive	JJ
cord-270892-ycc3csyh	156	22	-	-	HYPH
cord-270892-ycc3csyh	156	23	stranded	strand	VBN
cord-270892-ycc3csyh	156	24	RNA	RNA	NNP
cord-270892-ycc3csyh	156	25	molecule	molecule	NN
cord-270892-ycc3csyh	156	26	of	of	IN
cord-270892-ycc3csyh	156	27	approximately	approximately	RB
cord-270892-ycc3csyh	156	28	7,400	7,400	CD
cord-270892-ycc3csyh	156	29	nucleotides	nucleotide	NNS
cord-270892-ycc3csyh	156	30	.	.	.
cord-270892-ycc3csyh	157	1	The	the	DT
cord-270892-ycc3csyh	157	2	organization	organization	NN
cord-270892-ycc3csyh	157	3	of	of	IN
cord-270892-ycc3csyh	157	4	the	the	DT
cord-270892-ycc3csyh	157	5	enterovirus	enterovirus	NN
cord-270892-ycc3csyh	157	6	genome	genome	NN
cord-270892-ycc3csyh	157	7	is	be	VBZ
cord-270892-ycc3csyh	157	8	shown	show	VBN
cord-270892-ycc3csyh	157	9	in	in	IN
cord-270892-ycc3csyh	157	10	Figure	figure	NN
cord-270892-ycc3csyh	157	11	1	1	CD
cord-270892-ycc3csyh	157	12	.	.	.
cord-270892-ycc3csyh	158	1	The	the	DT
cord-270892-ycc3csyh	158	2	viral	viral	JJ
cord-270892-ycc3csyh	158	3	genomic	genomic	JJ
cord-270892-ycc3csyh	158	4	RNA	RNA	NNP
cord-270892-ycc3csyh	158	5	is	be	VBZ
cord-270892-ycc3csyh	158	6	infectious	infectious	JJ
cord-270892-ycc3csyh	158	7	and	and	CC
cord-270892-ycc3csyh	158	8	encodes	encode	VBZ
cord-270892-ycc3csyh	158	9	a	a	DT
cord-270892-ycc3csyh	158	10	single	single	JJ
cord-270892-ycc3csyh	158	11	,	,	,
cord-270892-ycc3csyh	158	12	long	long	JJ
cord-270892-ycc3csyh	158	13	,	,	,
cord-270892-ycc3csyh	158	14	open	open	JJ
cord-270892-ycc3csyh	158	15	reading	reading	NN
cord-270892-ycc3csyh	158	16	frame	frame	NN
cord-270892-ycc3csyh	158	17	flanked	flank	VBN
cord-270892-ycc3csyh	158	18	by	by	IN
cord-270892-ycc3csyh	158	19	untranslated	untranslated	JJ
cord-270892-ycc3csyh	158	20	regions	region	NNS
cord-270892-ycc3csyh	158	21	(	(	-LRB-
cord-270892-ycc3csyh	158	22	UTR	UTR	NNP
cord-270892-ycc3csyh	158	23	)	)	-RRB-
cord-270892-ycc3csyh	158	24	at	at	IN
cord-270892-ycc3csyh	158	25	the	the	DT
cord-270892-ycc3csyh	158	26	5	5	CD
cord-270892-ycc3csyh	158	27	0	0	CD
cord-270892-ycc3csyh	158	28	and	and	CC
cord-270892-ycc3csyh	158	29	3	3	CD
cord-270892-ycc3csyh	158	30	0	0	CD
cord-270892-ycc3csyh	158	31	end	end	NN
cord-270892-ycc3csyh	158	32	.	.	.
cord-270892-ycc3csyh	159	1	A	a	DT
cord-270892-ycc3csyh	159	2	small	small	JJ
cord-270892-ycc3csyh	159	3	viral	viral	JJ
cord-270892-ycc3csyh	159	4	protein	protein	NN
cord-270892-ycc3csyh	159	5	(	(	-LRB-
cord-270892-ycc3csyh	159	6	VPg	VPg	NNS
cord-270892-ycc3csyh	159	7	)	)	-RRB-
cord-270892-ycc3csyh	159	8	is	be	VBZ
cord-270892-ycc3csyh	159	9	covalently	covalently	RB
cord-270892-ycc3csyh	159	10	linked	link	VBN
cord-270892-ycc3csyh	159	11	to	to	IN
cord-270892-ycc3csyh	159	12	the	the	DT
cord-270892-ycc3csyh	159	13	5	5	CD
cord-270892-ycc3csyh	159	14	0	0	CD
cord-270892-ycc3csyh	159	15	end	end	NN
cord-270892-ycc3csyh	159	16	.	.	.
cord-270892-ycc3csyh	160	1	The	the	DT
cord-270892-ycc3csyh	160	2	3	3	CD
cord-270892-ycc3csyh	160	3	0	0	CD
cord-270892-ycc3csyh	160	4	end	end	NN
cord-270892-ycc3csyh	160	5	is	be	VBZ
cord-270892-ycc3csyh	160	6	polyadenylated	polyadenylate	VBN
cord-270892-ycc3csyh	160	7	like	like	IN
cord-270892-ycc3csyh	160	8	cellular	cellular	JJ
cord-270892-ycc3csyh	160	9	messenger	messenger	NN
cord-270892-ycc3csyh	160	10	RNAs	rna	NNS
cord-270892-ycc3csyh	160	11	.	.	.
cord-270892-ycc3csyh	161	1	Structural	structural	JJ
cord-270892-ycc3csyh	161	2	components	component	NNS
cord-270892-ycc3csyh	161	3	within	within	IN
cord-270892-ycc3csyh	161	4	these	these	DT
cord-270892-ycc3csyh	161	5	UTRs	utr	NNS
cord-270892-ycc3csyh	161	6	e.g.	e.g.	IN
cord-270892-ycc3csyh	161	7	the	the	DT
cord-270892-ycc3csyh	161	8	cloverleaf	cloverleaf	NN
cord-270892-ycc3csyh	161	9	and	and	CC
cord-270892-ycc3csyh	161	10	the	the	DT
cord-270892-ycc3csyh	161	11	internal	internal	JJ
cord-270892-ycc3csyh	161	12	ribosome	ribosome	NN
cord-270892-ycc3csyh	161	13	entry	entry	NN
cord-270892-ycc3csyh	161	14	site	site	NN
cord-270892-ycc3csyh	161	15	(	(	-LRB-
cord-270892-ycc3csyh	161	16	IRES	IRES	NNP
cord-270892-ycc3csyh	161	17	)	)	-RRB-
cord-270892-ycc3csyh	161	18	of	of	IN
cord-270892-ycc3csyh	161	19	the	the	DT
cord-270892-ycc3csyh	161	20	5	5	CD
cord-270892-ycc3csyh	161	21	0	0	CD
cord-270892-ycc3csyh	161	22	UTR	UTR	NNP
cord-270892-ycc3csyh	161	23	play	play	VBP
cord-270892-ycc3csyh	161	24	an	an	DT
cord-270892-ycc3csyh	161	25	important	important	JJ
cord-270892-ycc3csyh	161	26	role	role	NN
cord-270892-ycc3csyh	161	27	in	in	IN
cord-270892-ycc3csyh	161	28	RNA	RNA	NNP
cord-270892-ycc3csyh	161	29	replication	replication	NN
cord-270892-ycc3csyh	161	30	as	as	RB
cord-270892-ycc3csyh	161	31	well	well	RB
cord-270892-ycc3csyh	161	32	as	as	IN
cord-270892-ycc3csyh	161	33	protein	protein	NN
cord-270892-ycc3csyh	161	34	synthesis	synthesis	NN
cord-270892-ycc3csyh	161	35	.	.	.
cord-270892-ycc3csyh	162	1	98	98	CD
cord-270892-ycc3csyh	163	1	The	the	DT
cord-270892-ycc3csyh	163	2	nucleotide	nucleotide	JJ
cord-270892-ycc3csyh	163	3	sequence	sequence	NN
cord-270892-ycc3csyh	163	4	of	of	IN
cord-270892-ycc3csyh	163	5	some	some	DT
cord-270892-ycc3csyh	163	6	regions	region	NNS
cord-270892-ycc3csyh	163	7	within	within	IN
cord-270892-ycc3csyh	163	8	these	these	DT
cord-270892-ycc3csyh	163	9	structures	structure	NNS
cord-270892-ycc3csyh	163	10	is	be	VBZ
cord-270892-ycc3csyh	163	11	highly	highly	RB
cord-270892-ycc3csyh	163	12	conserved	conserve	VBN
cord-270892-ycc3csyh	163	13	among	among	IN
cord-270892-ycc3csyh	163	14	enteroviruses	enterovirus	NNS
cord-270892-ycc3csyh	163	15	.	.	.
cord-270892-ycc3csyh	164	1	Their	-PRON-	PRP$
cord-270892-ycc3csyh	164	2	blockade	blockade	NN
cord-270892-ycc3csyh	164	3	could	could	MD
cord-270892-ycc3csyh	164	4	significantly	significantly	RB
cord-270892-ycc3csyh	164	5	inhibit	inhibit	VB
cord-270892-ycc3csyh	164	6	viral	viral	JJ
cord-270892-ycc3csyh	164	7	replication	replication	NN
cord-270892-ycc3csyh	164	8	.	.	.
cord-270892-ycc3csyh	165	1	The	the	DT
cord-270892-ycc3csyh	165	2	molecular	molecular	JJ
cord-270892-ycc3csyh	165	3	structure	structure	NN
cord-270892-ycc3csyh	165	4	of	of	IN
cord-270892-ycc3csyh	165	5	HRV-1A	HRV-1A	NNP
cord-270892-ycc3csyh	165	6	,	,	,
cord-270892-ycc3csyh	165	7	HRV-2	HRV-2	NNP
cord-270892-ycc3csyh	165	8	,	,	,
cord-270892-ycc3csyh	165	9	HRV-3	HRV-3	NNP
cord-270892-ycc3csyh	165	10	,	,	,
cord-270892-ycc3csyh	165	11	HRV-14	HRV-14	NNP
cord-270892-ycc3csyh	165	12	,	,	,
cord-270892-ycc3csyh	165	13	and	and	CC
cord-270892-ycc3csyh	165	14	HRV-16	HRV-16	NNP
cord-270892-ycc3csyh	165	15	was	be	VBD
cord-270892-ycc3csyh	165	16	determined	determine	VBN
cord-270892-ycc3csyh	165	17	by	by	IN
cord-270892-ycc3csyh	165	18	X	x	NN
cord-270892-ycc3csyh	165	19	-	-	NN
cord-270892-ycc3csyh	165	20	ray	ray	NN
cord-270892-ycc3csyh	165	21	crystallography	crystallography	NN
cord-270892-ycc3csyh	165	22	.	.	.
cord-270892-ycc3csyh	166	1	[	[	-LRB-
cord-270892-ycc3csyh	166	2	99	99	CD
cord-270892-ycc3csyh	166	3	]	]	-RRB-
cord-270892-ycc3csyh	166	4	[	[	-LRB-
cord-270892-ycc3csyh	166	5	100	100	CD
cord-270892-ycc3csyh	166	6	]	]	-RRB-
cord-270892-ycc3csyh	166	7	[	[	-LRB-
cord-270892-ycc3csyh	166	8	101	101	CD
cord-270892-ycc3csyh	166	9	]	]	-RRB-
cord-270892-ycc3csyh	166	10	[	[	-LRB-
cord-270892-ycc3csyh	166	11	102	102	CD
cord-270892-ycc3csyh	166	12	]	]	-RRB-
cord-270892-ycc3csyh	166	13	[	[	-LRB-
cord-270892-ycc3csyh	166	14	103	103	CD
cord-270892-ycc3csyh	166	15	]	]	-RRB-
cord-270892-ycc3csyh	166	16	[	[	-LRB-
cord-270892-ycc3csyh	166	17	104	104	CD
cord-270892-ycc3csyh	166	18	]	]	-RRB-
cord-270892-ycc3csyh	167	1	[	[	-LRB-
cord-270892-ycc3csyh	167	2	105	105	CD
cord-270892-ycc3csyh	167	3	]	]	-RRB-
cord-270892-ycc3csyh	168	1	The	the	DT
cord-270892-ycc3csyh	168	2	results	result	NNS
cord-270892-ycc3csyh	168	3	show	show	VBP
cord-270892-ycc3csyh	168	4	that	that	IN
cord-270892-ycc3csyh	168	5	the	the	DT
cord-270892-ycc3csyh	168	6	viral	viral	JJ
cord-270892-ycc3csyh	168	7	capsid	capsid	NN
cord-270892-ycc3csyh	168	8	is	be	VBZ
cord-270892-ycc3csyh	168	9	composed	compose	VBN
cord-270892-ycc3csyh	168	10	of	of	IN
cord-270892-ycc3csyh	168	11	60	60	CD
cord-270892-ycc3csyh	168	12	protomers	protomer	NNS
cord-270892-ycc3csyh	168	13	of	of	IN
cord-270892-ycc3csyh	168	14	each	each	DT
cord-270892-ycc3csyh	168	15	of	of	IN
cord-270892-ycc3csyh	168	16	the	the	DT
cord-270892-ycc3csyh	168	17	three	three	CD
cord-270892-ycc3csyh	168	18	outer	outer	JJ
cord-270892-ycc3csyh	168	19	structural	structural	JJ
cord-270892-ycc3csyh	168	20	proteins	protein	NNS
cord-270892-ycc3csyh	168	21	VP1	VP1	NNP
cord-270892-ycc3csyh	168	22	,	,	,
cord-270892-ycc3csyh	168	23	VP2	vp2	NN
cord-270892-ycc3csyh	168	24	,	,	,
cord-270892-ycc3csyh	168	25	and	and	CC
cord-270892-ycc3csyh	168	26	VP3	vp3	NN
cord-270892-ycc3csyh	168	27	and	and	CC
cord-270892-ycc3csyh	168	28	of	of	IN
cord-270892-ycc3csyh	168	29	VP4	VP4	NNP
cord-270892-ycc3csyh	168	30	in	in	IN
cord-270892-ycc3csyh	168	31	the	the	DT
cord-270892-ycc3csyh	168	32	interior	interior	NN
cord-270892-ycc3csyh	168	33	.	.	.
cord-270892-ycc3csyh	169	1	A	a	DT
cord-270892-ycc3csyh	169	2	star	star	NN
cord-270892-ycc3csyh	169	3	-	-	HYPH
cord-270892-ycc3csyh	169	4	shaped	shape	VBN
cord-270892-ycc3csyh	169	5	plateau	plateau	NN
cord-270892-ycc3csyh	169	6	at	at	IN
cord-270892-ycc3csyh	169	7	the	the	DT
cord-270892-ycc3csyh	169	8	fivefold	fivefold	JJ
cord-270892-ycc3csyh	169	9	axis	axis	NN
cord-270892-ycc3csyh	169	10	of	of	IN
cord-270892-ycc3csyh	169	11	symmetry	symmetry	NN
cord-270892-ycc3csyh	169	12	,	,	,
cord-270892-ycc3csyh	169	13	surrounded	surround	VBN
cord-270892-ycc3csyh	169	14	by	by	IN
cord-270892-ycc3csyh	169	15	a	a	DT
cord-270892-ycc3csyh	169	16	deep	deep	JJ
cord-270892-ycc3csyh	169	17	depression	depression	NN
cord-270892-ycc3csyh	169	18	(	(	-LRB-
cord-270892-ycc3csyh	169	19	canyon	canyon	NN
cord-270892-ycc3csyh	169	20	)	)	-RRB-
cord-270892-ycc3csyh	169	21	and	and	CC
cord-270892-ycc3csyh	169	22	another	another	DT
cord-270892-ycc3csyh	169	23	smaller	small	JJR
cord-270892-ycc3csyh	169	24	depression	depression	NN
cord-270892-ycc3csyh	169	25	at	at	IN
cord-270892-ycc3csyh	169	26	the	the	DT
cord-270892-ycc3csyh	169	27	threefold	threefold	JJ
cord-270892-ycc3csyh	169	28	axis	axis	NN
cord-270892-ycc3csyh	169	29	were	be	VBD
cord-270892-ycc3csyh	169	30	detected	detect	VBN
cord-270892-ycc3csyh	169	31	.	.	.
cord-270892-ycc3csyh	170	1	Moreover	moreover	RB
cord-270892-ycc3csyh	170	2	,	,	,
cord-270892-ycc3csyh	170	3	a	a	DT
cord-270892-ycc3csyh	170	4	hydrophobic	hydrophobic	JJ
cord-270892-ycc3csyh	170	5	pocket	pocket	NN
cord-270892-ycc3csyh	170	6	was	be	VBD
cord-270892-ycc3csyh	170	7	found	find	VBN
cord-270892-ycc3csyh	170	8	beneath	beneath	IN
cord-270892-ycc3csyh	170	9	the	the	DT
cord-270892-ycc3csyh	170	10	canyon	canyon	NN
cord-270892-ycc3csyh	170	11	floor	floor	NN
cord-270892-ycc3csyh	170	12	.	.	.
cord-270892-ycc3csyh	171	1	With	with	IN
cord-270892-ycc3csyh	171	2	exception	exception	NN
cord-270892-ycc3csyh	171	3	of	of	IN
cord-270892-ycc3csyh	171	4	HRV-14	HRV-14	NNP
cord-270892-ycc3csyh	171	5	and	and	CC
cord-270892-ycc3csyh	171	6	HRV-3	HRV-3	NNP
cord-270892-ycc3csyh	171	7	,	,	,
cord-270892-ycc3csyh	171	8	this	this	DT
cord-270892-ycc3csyh	171	9	pocket	pocket	NN
cord-270892-ycc3csyh	171	10	is	be	VBZ
cord-270892-ycc3csyh	171	11	occupied	occupy	VBN
cord-270892-ycc3csyh	171	12	by	by	IN
cord-270892-ycc3csyh	171	13	a	a	DT
cord-270892-ycc3csyh	171	14	fatty	fatty	JJ
cord-270892-ycc3csyh	171	15	acid	acid	NN
cord-270892-ycc3csyh	171	16	,	,	,
cord-270892-ycc3csyh	171	17	the	the	DT
cord-270892-ycc3csyh	171	18	so	so	RB
cord-270892-ycc3csyh	171	19	-	-	HYPH
cord-270892-ycc3csyh	171	20	called	call	VBN
cord-270892-ycc3csyh	171	21	pocket	pocket	NN
cord-270892-ycc3csyh	171	22	factor	factor	NN
cord-270892-ycc3csyh	171	23	.	.	.
cord-270892-ycc3csyh	172	1	These	these	DT
cord-270892-ycc3csyh	172	2	host	host	NN
cord-270892-ycc3csyh	172	3	cell	cell	NN
cord-270892-ycc3csyh	172	4	molecules	molecule	NNS
cord-270892-ycc3csyh	172	5	have	have	VBP
cord-270892-ycc3csyh	172	6	been	be	VBN
cord-270892-ycc3csyh	172	7	suggested	suggest	VBN
cord-270892-ycc3csyh	172	8	to	to	TO
cord-270892-ycc3csyh	172	9	play	play	VB
cord-270892-ycc3csyh	172	10	an	an	DT
cord-270892-ycc3csyh	172	11	important	important	JJ
cord-270892-ycc3csyh	172	12	role	role	NN
cord-270892-ycc3csyh	172	13	in	in	IN
cord-270892-ycc3csyh	172	14	the	the	DT
cord-270892-ycc3csyh	172	15	viral	viral	JJ
cord-270892-ycc3csyh	172	16	life	life	NN
cord-270892-ycc3csyh	172	17	cycle	cycle	NN
cord-270892-ycc3csyh	172	18	by	by	IN
cord-270892-ycc3csyh	172	19	providing	provide	VBG
cord-270892-ycc3csyh	172	20	transient	transient	JJ
cord-270892-ycc3csyh	172	21	stability	stability	NN
cord-270892-ycc3csyh	172	22	to	to	IN
cord-270892-ycc3csyh	172	23	the	the	DT
cord-270892-ycc3csyh	172	24	capsid	capsid	NN
cord-270892-ycc3csyh	172	25	during	during	IN
cord-270892-ycc3csyh	172	26	its	-PRON-	PRP$
cord-270892-ycc3csyh	172	27	movement	movement	NN
cord-270892-ycc3csyh	172	28	from	from	IN
cord-270892-ycc3csyh	172	29	one	one	CD
cord-270892-ycc3csyh	172	30	host	host	NN
cord-270892-ycc3csyh	172	31	cell	cell	NN
cord-270892-ycc3csyh	172	32	to	to	IN
cord-270892-ycc3csyh	172	33	another	another	DT
cord-270892-ycc3csyh	172	34	.	.	.
cord-270892-ycc3csyh	173	1	102	102	CD
cord-270892-ycc3csyh	174	1	The	the	DT
cord-270892-ycc3csyh	174	2	outer	outer	JJ
cord-270892-ycc3csyh	174	3	surface	surface	NN
cord-270892-ycc3csyh	174	4	of	of	IN
cord-270892-ycc3csyh	174	5	virions	virion	NNS
cord-270892-ycc3csyh	174	6	contains	contain	VBZ
cord-270892-ycc3csyh	174	7	neutralization	neutralization	NN
cord-270892-ycc3csyh	174	8	antigenic	antigenic	JJ
cord-270892-ycc3csyh	174	9	as	as	RB
cord-270892-ycc3csyh	174	10	well	well	RB
cord-270892-ycc3csyh	174	11	as	as	IN
cord-270892-ycc3csyh	174	12	host	host	NN
cord-270892-ycc3csyh	174	13	cell	cell	NN
cord-270892-ycc3csyh	174	14	binding	bind	VBG
cord-270892-ycc3csyh	174	15	sites	site	NNS
cord-270892-ycc3csyh	174	16	.	.	.
cord-270892-ycc3csyh	175	1	The	the	DT
cord-270892-ycc3csyh	175	2	latter	latter	JJ
cord-270892-ycc3csyh	175	3	allow	allow	VBP
cord-270892-ycc3csyh	175	4	the	the	DT
cord-270892-ycc3csyh	175	5	virus	virus	NN
cord-270892-ycc3csyh	175	6	to	to	TO
cord-270892-ycc3csyh	175	7	attach	attach	VB
cord-270892-ycc3csyh	175	8	to	to	IN
cord-270892-ycc3csyh	175	9	molecules	molecule	NNS
cord-270892-ycc3csyh	175	10	of	of	IN
cord-270892-ycc3csyh	175	11	the	the	DT
cord-270892-ycc3csyh	175	12	host	host	NN
cord-270892-ycc3csyh	175	13	cell	cell	NN
cord-270892-ycc3csyh	175	14	membrane	membrane	NN
cord-270892-ycc3csyh	175	15	(	(	-LRB-
cord-270892-ycc3csyh	175	16	adsorption	adsorption	NN
cord-270892-ycc3csyh	175	17	)	)	-RRB-
cord-270892-ycc3csyh	175	18	,	,	,
cord-270892-ycc3csyh	175	19	the	the	DT
cord-270892-ycc3csyh	175	20	receptors	receptor	NNS
cord-270892-ycc3csyh	175	21	,	,	,
cord-270892-ycc3csyh	175	22	and	and	CC
cord-270892-ycc3csyh	175	23	to	to	TO
cord-270892-ycc3csyh	175	24	start	start	VB
cord-270892-ycc3csyh	175	25	their	-PRON-	PRP$
cord-270892-ycc3csyh	175	26	life	life	NN
cord-270892-ycc3csyh	175	27	cycle	cycle	NN
cord-270892-ycc3csyh	175	28	.	.	.
cord-270892-ycc3csyh	176	1	[	[	-LRB-
cord-270892-ycc3csyh	176	2	106	106	CD
cord-270892-ycc3csyh	176	3	]	]	-RRB-
cord-270892-ycc3csyh	176	4	[	[	-LRB-
cord-270892-ycc3csyh	176	5	107	107	CD
cord-270892-ycc3csyh	176	6	]	]	-RRB-
cord-270892-ycc3csyh	177	1	[	[	-LRB-
cord-270892-ycc3csyh	177	2	108	108	CD
cord-270892-ycc3csyh	177	3	]	]	-RRB-
cord-270892-ycc3csyh	178	1	Based	base	VBN
cord-270892-ycc3csyh	178	2	on	on	IN
cord-270892-ycc3csyh	178	3	their	-PRON-	PRP$
cord-270892-ycc3csyh	178	4	receptor	receptor	NN
cord-270892-ycc3csyh	178	5	use	use	NN
cord-270892-ycc3csyh	178	6	,	,	,
cord-270892-ycc3csyh	178	7	two	two	CD
cord-270892-ycc3csyh	178	8	groups	group	NNS
cord-270892-ycc3csyh	178	9	of	of	IN
cord-270892-ycc3csyh	178	10	HRV	HRV	NNP
cord-270892-ycc3csyh	178	11	can	can	MD
cord-270892-ycc3csyh	178	12	be	be	VB
cord-270892-ycc3csyh	178	13	distinguished	distinguish	VBN
cord-270892-ycc3csyh	178	14	.	.	.
cord-270892-ycc3csyh	179	1	The	the	DT
cord-270892-ycc3csyh	179	2	majority	majority	NN
cord-270892-ycc3csyh	179	3	of	of	IN
cord-270892-ycc3csyh	179	4	HRV	HRV	NNP
cord-270892-ycc3csyh	179	5	serotypes	serotype	NNS
cord-270892-ycc3csyh	179	6	,	,	,
cord-270892-ycc3csyh	179	7	the	the	DT
cord-270892-ycc3csyh	179	8	major	major	JJ
cord-270892-ycc3csyh	179	9	group	group	NN
cord-270892-ycc3csyh	179	10	uses	use	VBZ
cord-270892-ycc3csyh	179	11	intercellular	intercellular	JJ
cord-270892-ycc3csyh	179	12	adhesion	adhesion	NN
cord-270892-ycc3csyh	179	13	molecule-1	molecule-1	NN
cord-270892-ycc3csyh	179	14	(	(	-LRB-
cord-270892-ycc3csyh	179	15	ICAM-1	ICAM-1	NNP
cord-270892-ycc3csyh	179	16	)	)	-RRB-
cord-270892-ycc3csyh	179	17	as	as	IN
cord-270892-ycc3csyh	179	18	their	-PRON-	PRP$
cord-270892-ycc3csyh	179	19	receptor	receptor	NN
cord-270892-ycc3csyh	179	20	.	.	.
cord-270892-ycc3csyh	180	1	109	109	CD
cord-270892-ycc3csyh	180	2	The	the	DT
cord-270892-ycc3csyh	180	3	12	12	CD
cord-270892-ycc3csyh	180	4	viruses	virus	NNS
cord-270892-ycc3csyh	180	5	belonging	belong	VBG
cord-270892-ycc3csyh	180	6	to	to	IN
cord-270892-ycc3csyh	180	7	the	the	DT
cord-270892-ycc3csyh	180	8	minor	minor	JJ
cord-270892-ycc3csyh	180	9	group	group	NN
cord-270892-ycc3csyh	180	10	attach	attach	VBP
cord-270892-ycc3csyh	180	11	to	to	IN
cord-270892-ycc3csyh	180	12	low	low	JJ
cord-270892-ycc3csyh	180	13	density	density	NN
cord-270892-ycc3csyh	180	14	lipoprotein	lipoprotein	NN
cord-270892-ycc3csyh	180	15	(	(	-LRB-
cord-270892-ycc3csyh	180	16	LDL	LDL	NNP
cord-270892-ycc3csyh	180	17	)	)	-RRB-
cord-270892-ycc3csyh	180	18	receptor	receptor	NN
cord-270892-ycc3csyh	180	19	,	,	,
cord-270892-ycc3csyh	180	20	very	very	RB
cord-270892-ycc3csyh	180	21	-	-	HYPH
cord-270892-ycc3csyh	180	22	LDL	ldl	NN
cord-270892-ycc3csyh	180	23	(	(	-LRB-
cord-270892-ycc3csyh	180	24	VLDL	VLDL	NNP
cord-270892-ycc3csyh	180	25	)	)	-RRB-
cord-270892-ycc3csyh	180	26	receptor	receptor	NN
cord-270892-ycc3csyh	180	27	,	,	,
cord-270892-ycc3csyh	180	28	and	and	CC
cord-270892-ycc3csyh	180	29	LDLR	LDLR	NNP
cord-270892-ycc3csyh	180	30	-	-	HYPH
cord-270892-ycc3csyh	180	31	related	relate	VBN
cord-270892-ycc3csyh	180	32	protein	protein	NN
cord-270892-ycc3csyh	180	33	on	on	IN
cord-270892-ycc3csyh	180	34	the	the	DT
cord-270892-ycc3csyh	180	35	cells	cell	NNS
cord-270892-ycc3csyh	180	36	whereat	whereat	NN
cord-270892-ycc3csyh	180	37	multiple	multiple	JJ
cord-270892-ycc3csyh	180	38	receptors	receptor	NNS
cord-270892-ycc3csyh	180	39	are	be	VBP
cord-270892-ycc3csyh	180	40	involved	involve	VBN
cord-270892-ycc3csyh	180	41	.	.	.
cord-270892-ycc3csyh	181	1	[	[	-LRB-
cord-270892-ycc3csyh	181	2	110	110	CD
cord-270892-ycc3csyh	181	3	]	]	-RRB-
cord-270892-ycc3csyh	181	4	[	[	-LRB-
cord-270892-ycc3csyh	181	5	111	111	CD
cord-270892-ycc3csyh	181	6	]	]	-RRB-
cord-270892-ycc3csyh	182	1	[	[	-LRB-
cord-270892-ycc3csyh	182	2	112	112	CD
cord-270892-ycc3csyh	182	3	]	]	-RRB-
cord-270892-ycc3csyh	182	4	HRV	HRV	NNP
cord-270892-ycc3csyh	182	5	of	of	IN
cord-270892-ycc3csyh	182	6	the	the	DT
cord-270892-ycc3csyh	182	7	major	major	JJ
cord-270892-ycc3csyh	182	8	group	group	NN
cord-270892-ycc3csyh	182	9	apply	apply	VBP
cord-270892-ycc3csyh	182	10	the	the	DT
cord-270892-ycc3csyh	182	11	canyon	canyon	NN
cord-270892-ycc3csyh	182	12	as	as	IN
cord-270892-ycc3csyh	182	13	attachment	attachment	NN
cord-270892-ycc3csyh	182	14	site	site	NN
cord-270892-ycc3csyh	182	15	for	for	IN
cord-270892-ycc3csyh	182	16	binding	bind	VBG
cord-270892-ycc3csyh	182	17	to	to	IN
cord-270892-ycc3csyh	182	18	ICAM-1	ICAM-1	NNP
cord-270892-ycc3csyh	182	19	.	.	.
cord-270892-ycc3csyh	183	1	113	113	CD
cord-270892-ycc3csyh	184	1	In	in	IN
cord-270892-ycc3csyh	184	2	contrast	contrast	NN
cord-270892-ycc3csyh	184	3	,	,	,
cord-270892-ycc3csyh	184	4	LDL	ldl	NN
cord-270892-ycc3csyh	184	5	receptors	receptor	NNS
cord-270892-ycc3csyh	184	6	of	of	IN
cord-270892-ycc3csyh	184	7	minor	minor	JJ
cord-270892-ycc3csyh	184	8	group	group	NN
cord-270892-ycc3csyh	184	9	viruses	virus	NNS
cord-270892-ycc3csyh	184	10	bind	bind	VBP
cord-270892-ycc3csyh	184	11	near	near	IN
cord-270892-ycc3csyh	184	12	the	the	DT
cord-270892-ycc3csyh	184	13	tip	tip	NN
cord-270892-ycc3csyh	184	14	of	of	IN
cord-270892-ycc3csyh	184	15	the	the	DT
cord-270892-ycc3csyh	184	16	five	five	CD
cord-270892-ycc3csyh	184	17	-	-	HYPH
cord-270892-ycc3csyh	184	18	fold	fold	JJ
cord-270892-ycc3csyh	184	19	vertex	vertex	NN
cord-270892-ycc3csyh	184	20	.	.	.
cord-270892-ycc3csyh	185	1	114	114	CD
cord-270892-ycc3csyh	185	2	HRV-87	HRV-87	NNP
cord-270892-ycc3csyh	185	3	has	have	VBZ
cord-270892-ycc3csyh	185	4	been	be	VBN
cord-270892-ycc3csyh	185	5	shown	show	VBN
cord-270892-ycc3csyh	185	6	to	to	TO
cord-270892-ycc3csyh	185	7	utilize	utilize	VB
cord-270892-ycc3csyh	185	8	a	a	DT
cord-270892-ycc3csyh	185	9	sialylated	sialylated	JJ
cord-270892-ycc3csyh	185	10	glycoprotein	glycoprotein	NN
cord-270892-ycc3csyh	185	11	as	as	IN
cord-270892-ycc3csyh	185	12	a	a	DT
cord-270892-ycc3csyh	185	13	cellular	cellular	JJ
cord-270892-ycc3csyh	185	14	receptor	receptor	NN
cord-270892-ycc3csyh	185	15	.	.	.
cord-270892-ycc3csyh	186	1	115	115	CD
cord-270892-ycc3csyh	187	1	Furthermore	furthermore	RB
cord-270892-ycc3csyh	187	2	,	,	,
cord-270892-ycc3csyh	187	3	a	a	DT
cord-270892-ycc3csyh	187	4	HRV-89	HRV-89	NNP
cord-270892-ycc3csyh	187	5	variant	variant	NN
cord-270892-ycc3csyh	187	6	as	as	RB
cord-270892-ycc3csyh	187	7	well	well	RB
cord-270892-ycc3csyh	187	8	as	as	IN
cord-270892-ycc3csyh	187	9	wild	wild	JJ
cord-270892-ycc3csyh	187	10	-	-	HYPH
cord-270892-ycc3csyh	187	11	type	type	NN
cord-270892-ycc3csyh	187	12	HRV-54	HRV-54	NNP
cord-270892-ycc3csyh	187	13	can	can	MD
cord-270892-ycc3csyh	187	14	use	use	VB
cord-270892-ycc3csyh	187	15	heparan	heparan	NN
cord-270892-ycc3csyh	187	16	sulphate	sulphate	NN
cord-270892-ycc3csyh	187	17	proteoglycans	proteoglycan	NNS
cord-270892-ycc3csyh	187	18	for	for	IN
cord-270892-ycc3csyh	187	19	cell	cell	NN
cord-270892-ycc3csyh	187	20	attachment	attachment	NN
cord-270892-ycc3csyh	187	21	in	in	IN
cord-270892-ycc3csyh	187	22	addition	addition	NN
cord-270892-ycc3csyh	187	23	to	to	IN
cord-270892-ycc3csyh	187	24	ICAM-1	ICAM-1	NNP
cord-270892-ycc3csyh	187	25	.	.	.
cord-270892-ycc3csyh	188	1	116	116	CD
cord-270892-ycc3csyh	188	2	,	,	,
cord-270892-ycc3csyh	188	3	117	117	CD
cord-270892-ycc3csyh	189	1	The	the	DT
cord-270892-ycc3csyh	189	2	interaction	interaction	NN
cord-270892-ycc3csyh	189	3	of	of	IN
cord-270892-ycc3csyh	189	4	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	189	5	with	with	IN
cord-270892-ycc3csyh	189	6	their	-PRON-	PRP$
cord-270892-ycc3csyh	189	7	receptors	receptor	NNS
cord-270892-ycc3csyh	189	8	leads	lead	VBZ
cord-270892-ycc3csyh	189	9	to	to	IN
cord-270892-ycc3csyh	189	10	virus	virus	NN
cord-270892-ycc3csyh	189	11	concentration	concentration	NN
cord-270892-ycc3csyh	189	12	on	on	IN
cord-270892-ycc3csyh	189	13	the	the	DT
cord-270892-ycc3csyh	189	14	cell	cell	NN
cord-270892-ycc3csyh	189	15	surface	surface	NN
cord-270892-ycc3csyh	189	16	.	.	.
cord-270892-ycc3csyh	190	1	It	-PRON-	PRP
cord-270892-ycc3csyh	190	2	induces	induce	VBZ
cord-270892-ycc3csyh	190	3	the	the	DT
cord-270892-ycc3csyh	190	4	release	release	NN
cord-270892-ycc3csyh	190	5	of	of	IN
cord-270892-ycc3csyh	190	6	the	the	DT
cord-270892-ycc3csyh	190	7	pocket	pocket	NN
cord-270892-ycc3csyh	190	8	factor	factor	NN
cord-270892-ycc3csyh	190	9	and	and	CC
cord-270892-ycc3csyh	190	10	conformational	conformational	JJ
cord-270892-ycc3csyh	190	11	changes	change	NNS
cord-270892-ycc3csyh	190	12	in	in	IN
cord-270892-ycc3csyh	190	13	the	the	DT
cord-270892-ycc3csyh	190	14	capsid	capsid	NN
cord-270892-ycc3csyh	190	15	and	and	CC
cord-270892-ycc3csyh	190	16	mediates	mediate	VBZ
cord-270892-ycc3csyh	190	17	viral	viral	JJ
cord-270892-ycc3csyh	190	18	entry	entry	NN
cord-270892-ycc3csyh	190	19	via	via	IN
cord-270892-ycc3csyh	190	20	endocytosis	endocytosis	NN
cord-270892-ycc3csyh	190	21	.	.	.
cord-270892-ycc3csyh	191	1	[	[	-LRB-
cord-270892-ycc3csyh	191	2	118	118	CD
cord-270892-ycc3csyh	191	3	]	]	-RRB-
cord-270892-ycc3csyh	191	4	[	[	-LRB-
cord-270892-ycc3csyh	191	5	119	119	CD
cord-270892-ycc3csyh	191	6	]	]	-RRB-
cord-270892-ycc3csyh	191	7	[	[	-LRB-
cord-270892-ycc3csyh	191	8	120	120	CD
cord-270892-ycc3csyh	191	9	]	]	-RRB-
cord-270892-ycc3csyh	192	1	[	[	-LRB-
cord-270892-ycc3csyh	192	2	121	121	CD
cord-270892-ycc3csyh	192	3	]	]	-RRB-
cord-270892-ycc3csyh	193	1	Whereas	whereas	IN
cord-270892-ycc3csyh	193	2	ICAM-1	icam-1	NN
cord-270892-ycc3csyh	193	3	binding	bind	VBG
cord-270892-ycc3csyh	193	4	directly	directly	RB
cord-270892-ycc3csyh	193	5	causes	cause	VBZ
cord-270892-ycc3csyh	193	6	uncoating	uncoating	NN
cord-270892-ycc3csyh	193	7	,	,	,
cord-270892-ycc3csyh	193	8	122	122	CD
cord-270892-ycc3csyh	193	9	,	,	,
cord-270892-ycc3csyh	193	10	123	123	CD
cord-270892-ycc3csyh	193	11	release	release	NN
cord-270892-ycc3csyh	193	12	of	of	IN
cord-270892-ycc3csyh	193	13	the	the	DT
cord-270892-ycc3csyh	193	14	RNA	RNA	NNP
cord-270892-ycc3csyh	193	15	genome	genome	NN
cord-270892-ycc3csyh	193	16	from	from	IN
cord-270892-ycc3csyh	193	17	the	the	DT
cord-270892-ycc3csyh	193	18	capsid	capsid	NN
cord-270892-ycc3csyh	193	19	of	of	IN
cord-270892-ycc3csyh	193	20	LDL	ldl	NN
cord-270892-ycc3csyh	193	21	-	-	HYPH
cord-270892-ycc3csyh	193	22	bound	bind	VBN
cord-270892-ycc3csyh	193	23	minor	minor	JJ
cord-270892-ycc3csyh	193	24	group	group	NN
cord-270892-ycc3csyh	193	25	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	193	26	is	be	VBZ
cord-270892-ycc3csyh	193	27	triggered	trigger	VBN
cord-270892-ycc3csyh	193	28	by	by	IN
cord-270892-ycc3csyh	193	29	acidification	acidification	NN
cord-270892-ycc3csyh	193	30	of	of	IN
cord-270892-ycc3csyh	193	31	the	the	DT
cord-270892-ycc3csyh	193	32	endosomal	endosomal	NNP
cord-270892-ycc3csyh	193	33	,	,	,
cord-270892-ycc3csyh	193	34	pH	ph	NN
cord-270892-ycc3csyh	193	35	-	-	HYPH
cord-270892-ycc3csyh	193	36	dependent	dependent	JJ
cord-270892-ycc3csyh	193	37	pathway	pathway	NN
cord-270892-ycc3csyh	193	38	.	.	.
cord-270892-ycc3csyh	194	1	[	[	-LRB-
cord-270892-ycc3csyh	194	2	124	124	CD
cord-270892-ycc3csyh	194	3	]	]	-RRB-
cord-270892-ycc3csyh	195	1	[	[	-LRB-
cord-270892-ycc3csyh	195	2	125	125	CD
cord-270892-ycc3csyh	195	3	]	]	-RRB-
cord-270892-ycc3csyh	196	1	[	[	-LRB-
cord-270892-ycc3csyh	196	2	126	126	CD
cord-270892-ycc3csyh	196	3	]	]	-RRB-
cord-270892-ycc3csyh	197	1	This	this	DT
cord-270892-ycc3csyh	197	2	detailed	detailed	JJ
cord-270892-ycc3csyh	197	3	knowledge	knowledge	NN
cord-270892-ycc3csyh	197	4	of	of	IN
cord-270892-ycc3csyh	197	5	the	the	DT
cord-270892-ycc3csyh	197	6	capsid	capsid	JJ
cord-270892-ycc3csyh	197	7	structure	structure	NN
cord-270892-ycc3csyh	197	8	and	and	CC
cord-270892-ycc3csyh	197	9	function	function	NN
cord-270892-ycc3csyh	197	10	as	as	RB
cord-270892-ycc3csyh	197	11	well	well	RB
cord-270892-ycc3csyh	197	12	as	as	IN
cord-270892-ycc3csyh	197	13	of	of	IN
cord-270892-ycc3csyh	197	14	the	the	DT
cord-270892-ycc3csyh	197	15	virus	virus	NN
cord-270892-ycc3csyh	197	16	-	-	HYPH
cord-270892-ycc3csyh	197	17	receptor	receptor	NN
cord-270892-ycc3csyh	197	18	interaction	interaction	NN
cord-270892-ycc3csyh	197	19	offers	offer	VBZ
cord-270892-ycc3csyh	197	20	a	a	DT
cord-270892-ycc3csyh	197	21	good	good	JJ
cord-270892-ycc3csyh	197	22	possibility	possibility	NN
cord-270892-ycc3csyh	197	23	to	to	TO
cord-270892-ycc3csyh	197	24	develop	develop	VB
cord-270892-ycc3csyh	197	25	antiviral	antiviral	JJ
cord-270892-ycc3csyh	197	26	drugs	drug	NNS
cord-270892-ycc3csyh	197	27	that	that	WDT
cord-270892-ycc3csyh	197	28	interfere	interfere	VBP
cord-270892-ycc3csyh	197	29	with	with	IN
cord-270892-ycc3csyh	197	30	the	the	DT
cord-270892-ycc3csyh	197	31	first	first	JJ
cord-270892-ycc3csyh	197	32	steps	step	NNS
cord-270892-ycc3csyh	197	33	of	of	IN
cord-270892-ycc3csyh	197	34	the	the	DT
cord-270892-ycc3csyh	197	35	viral	viral	JJ
cord-270892-ycc3csyh	197	36	life	life	NN
cord-270892-ycc3csyh	197	37	cycle	cycle	NN
cord-270892-ycc3csyh	197	38	,	,	,
cord-270892-ycc3csyh	197	39	adsorption	adsorption	NN
cord-270892-ycc3csyh	197	40	as	as	RB
cord-270892-ycc3csyh	197	41	well	well	RB
cord-270892-ycc3csyh	197	42	as	as	IN
cord-270892-ycc3csyh	197	43	uncoating	uncoating	NN
cord-270892-ycc3csyh	197	44	.	.	.
cord-270892-ycc3csyh	198	1	After	after	IN
cord-270892-ycc3csyh	198	2	uncoating	uncoate	VBG
cord-270892-ycc3csyh	198	3	,	,	,
cord-270892-ycc3csyh	198	4	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	198	5	proteins	protein	NNS
cord-270892-ycc3csyh	198	6	are	be	VBP
cord-270892-ycc3csyh	198	7	synthesized	synthesize	VBN
cord-270892-ycc3csyh	198	8	by	by	IN
cord-270892-ycc3csyh	198	9	the	the	DT
cord-270892-ycc3csyh	198	10	translation	translation	NN
cord-270892-ycc3csyh	198	11	of	of	IN
cord-270892-ycc3csyh	198	12	a	a	DT
cord-270892-ycc3csyh	198	13	single	single	JJ
cord-270892-ycc3csyh	198	14	,	,	,
cord-270892-ycc3csyh	198	15	open	open	JJ
cord-270892-ycc3csyh	198	16	reading	reading	NN
cord-270892-ycc3csyh	198	17	frame	frame	NN
cord-270892-ycc3csyh	198	18	using	use	VBG
cord-270892-ycc3csyh	198	19	cellular	cellular	JJ
cord-270892-ycc3csyh	198	20	ribosomes	ribosome	NNS
cord-270892-ycc3csyh	198	21	.	.	.
cord-270892-ycc3csyh	199	1	The	the	DT
cord-270892-ycc3csyh	199	2	resulting	result	VBG
cord-270892-ycc3csyh	199	3	polyprotein	polyprotein	NN
cord-270892-ycc3csyh	199	4	of	of	IN
cord-270892-ycc3csyh	199	5	approximately	approximately	RB
cord-270892-ycc3csyh	199	6	250	250	CD
cord-270892-ycc3csyh	199	7	kD	kd	JJ
cord-270892-ycc3csyh	199	8	is	be	VBZ
cord-270892-ycc3csyh	199	9	cleaved	cleave	VBN
cord-270892-ycc3csyh	199	10	by	by	IN
cord-270892-ycc3csyh	199	11	viral	viral	JJ
cord-270892-ycc3csyh	199	12	proteases	protease	NNS
cord-270892-ycc3csyh	199	13	2A	2a	CD
cord-270892-ycc3csyh	199	14	pro	pro	NNP
cord-270892-ycc3csyh	199	15	and	and	CC
cord-270892-ycc3csyh	199	16	3C	3C	NNP
cord-270892-ycc3csyh	199	17	pro	pro	NNP
cord-270892-ycc3csyh	199	18	into	into	IN
cord-270892-ycc3csyh	199	19	11	11	CD
cord-270892-ycc3csyh	199	20	final	final	JJ
cord-270892-ycc3csyh	199	21	products	product	NNS
cord-270892-ycc3csyh	199	22	(	(	-LRB-
cord-270892-ycc3csyh	199	23	4	4	CD
cord-270892-ycc3csyh	199	24	structural	structural	JJ
cord-270892-ycc3csyh	199	25	and	and	CC
cord-270892-ycc3csyh	199	26	7	7	CD
cord-270892-ycc3csyh	199	27	nonstrutural	nonstrutural	JJ
cord-270892-ycc3csyh	199	28	proteins	protein	NNS
cord-270892-ycc3csyh	199	29	)	)	-RRB-
cord-270892-ycc3csyh	199	30	immediately	immediately	RB
cord-270892-ycc3csyh	199	31	after	after	IN
cord-270892-ycc3csyh	199	32	translation	translation	NN
cord-270892-ycc3csyh	199	33	.	.	.
cord-270892-ycc3csyh	200	1	127	127	CD
cord-270892-ycc3csyh	200	2	,	,	,
cord-270892-ycc3csyh	200	3	128	128	CD
cord-270892-ycc3csyh	201	1	At	at	IN
cord-270892-ycc3csyh	201	2	first	first	RB
cord-270892-ycc3csyh	201	3	,	,	,
cord-270892-ycc3csyh	201	4	both	both	DT
cord-270892-ycc3csyh	201	5	proteinases	proteinases	NNP
cord-270892-ycc3csyh	201	6	release	release	VBP
cord-270892-ycc3csyh	201	7	themselves	-PRON-	PRP
cord-270892-ycc3csyh	201	8	from	from	IN
cord-270892-ycc3csyh	201	9	the	the	DT
cord-270892-ycc3csyh	201	10	polyprotein	polyprotein	NNP
cord-270892-ycc3csyh	201	11	by	by	IN
cord-270892-ycc3csyh	201	12	selfcleavage	selfcleavage	NNP
cord-270892-ycc3csyh	201	13	.	.	.
cord-270892-ycc3csyh	202	1	The	the	DT
cord-270892-ycc3csyh	202	2	primary	primary	JJ
cord-270892-ycc3csyh	202	3	cleavage	cleavage	NN
cord-270892-ycc3csyh	202	4	of	of	IN
cord-270892-ycc3csyh	202	5	the	the	DT
cord-270892-ycc3csyh	202	6	viral	viral	JJ
cord-270892-ycc3csyh	202	7	polyprotein	polyprotein	NN
cord-270892-ycc3csyh	202	8	between	between	IN
cord-270892-ycc3csyh	202	9	P1	P1	NNP
cord-270892-ycc3csyh	202	10	and	and	CC
cord-270892-ycc3csyh	202	11	P2	P2	NNP
cord-270892-ycc3csyh	202	12	is	be	VBZ
cord-270892-ycc3csyh	202	13	mediated	mediate	VBN
cord-270892-ycc3csyh	202	14	by	by	IN
cord-270892-ycc3csyh	202	15	2A	2a	CD
cord-270892-ycc3csyh	202	16	pro	pro	NNP
cord-270892-ycc3csyh	202	17	.	.	.
cord-270892-ycc3csyh	203	1	Thereafter	thereafter	RB
cord-270892-ycc3csyh	203	2	,	,	,
cord-270892-ycc3csyh	203	3	3CD	3cd	NN
cord-270892-ycc3csyh	203	4	pro	pro	NN
cord-270892-ycc3csyh	203	5	is	be	VBZ
cord-270892-ycc3csyh	203	6	released	release	VBN
cord-270892-ycc3csyh	203	7	from	from	IN
cord-270892-ycc3csyh	203	8	the	the	DT
cord-270892-ycc3csyh	203	9	P3	P3	NNP
cord-270892-ycc3csyh	203	10	precursor	precursor	NN
cord-270892-ycc3csyh	203	11	by	by	IN
cord-270892-ycc3csyh	203	12	autocatalytic	autocatalytic	JJ
cord-270892-ycc3csyh	203	13	cleavage	cleavage	NN
cord-270892-ycc3csyh	203	14	.	.	.
cord-270892-ycc3csyh	204	1	Next	next	RB
cord-270892-ycc3csyh	204	2	,	,	,
cord-270892-ycc3csyh	204	3	3C	3C	NNP
cord-270892-ycc3csyh	204	4	pro	pro	NNP
cord-270892-ycc3csyh	204	5	and	and	CC
cord-270892-ycc3csyh	204	6	its	-PRON-	PRP$
cord-270892-ycc3csyh	204	7	precursor	precursor	NN
cord-270892-ycc3csyh	204	8	3CD	3cd	CD
cord-270892-ycc3csyh	204	9	pro	pro	JJ
cord-270892-ycc3csyh	204	10	process	process	NN
cord-270892-ycc3csyh	204	11	proteins	protein	NNS
cord-270892-ycc3csyh	204	12	of	of	IN
cord-270892-ycc3csyh	204	13	the	the	DT
cord-270892-ycc3csyh	204	14	P1	P1	NNP
cord-270892-ycc3csyh	204	15	(	(	-LRB-
cord-270892-ycc3csyh	204	16	capsid	capsid	NN
cord-270892-ycc3csyh	204	17	proteins	protein	NNS
cord-270892-ycc3csyh	204	18	)	)	-RRB-
cord-270892-ycc3csyh	204	19	,	,	,
cord-270892-ycc3csyh	204	20	P2	P2	NNP
cord-270892-ycc3csyh	204	21	,	,	,
cord-270892-ycc3csyh	204	22	and	and	CC
cord-270892-ycc3csyh	204	23	P3	P3	NNP
cord-270892-ycc3csyh	204	24	(	(	-LRB-
cord-270892-ycc3csyh	204	25	nonstructural	nonstructural	JJ
cord-270892-ycc3csyh	204	26	proteins	protein	NNS
cord-270892-ycc3csyh	204	27	)	)	-RRB-
cord-270892-ycc3csyh	204	28	region	region	NN
cord-270892-ycc3csyh	204	29	.	.	.
cord-270892-ycc3csyh	205	1	Interestingly	interestingly	RB
cord-270892-ycc3csyh	205	2	,	,	,
cord-270892-ycc3csyh	205	3	2A	2A	NNP
cord-270892-ycc3csyh	205	4	pro	pro	NNP
cord-270892-ycc3csyh	205	5	cleaves	cleave	VBZ
cord-270892-ycc3csyh	205	6	also	also	RB
cord-270892-ycc3csyh	205	7	the	the	DT
cord-270892-ycc3csyh	205	8	eIF4GI	eIF4GI	NNP
cord-270892-ycc3csyh	205	9	/	/	SYM
cord-270892-ycc3csyh	205	10	II	II	NNP
cord-270892-ycc3csyh	205	11	component	component	NN
cord-270892-ycc3csyh	205	12	of	of	IN
cord-270892-ycc3csyh	205	13	the	the	DT
cord-270892-ycc3csyh	205	14	translation	translation	NN
cord-270892-ycc3csyh	205	15	initiation	initiation	NN
cord-270892-ycc3csyh	205	16	factor	factor	NN
cord-270892-ycc3csyh	205	17	eIF4F	eif4f	CD
cord-270892-ycc3csyh	205	18	necessary	necessary	JJ
cord-270892-ycc3csyh	205	19	for	for	IN
cord-270892-ycc3csyh	205	20	host	host	NN
cord-270892-ycc3csyh	205	21	cell	cell	NN
cord-270892-ycc3csyh	205	22	protein	protein	NN
cord-270892-ycc3csyh	205	23	synthesis	synthesis	NN
cord-270892-ycc3csyh	205	24	,	,	,
cord-270892-ycc3csyh	205	25	[	[	-LRB-
cord-270892-ycc3csyh	205	26	129	129	CD
cord-270892-ycc3csyh	205	27	]	]	-RRB-
cord-270892-ycc3csyh	206	1	[	[	-LRB-
cord-270892-ycc3csyh	206	2	130	130	CD
cord-270892-ycc3csyh	206	3	]	]	-RRB-
cord-270892-ycc3csyh	206	4	[	[	-LRB-
cord-270892-ycc3csyh	206	5	131	131	CD
cord-270892-ycc3csyh	206	6	]	]	-RRB-
cord-270892-ycc3csyh	206	7	and	and	CC
cord-270892-ycc3csyh	206	8	3C	3C	NNP
cord-270892-ycc3csyh	206	9	pro	pro	NNP
cord-270892-ycc3csyh	206	10	and/or	and/or	CC
cord-270892-ycc3csyh	207	1	3CD	3CD	NNP
cord-270892-ycc3csyh	207	2	pro	pro	VBP
cord-270892-ycc3csyh	207	3	the	the	DT
cord-270892-ycc3csyh	207	4	RNA	RNA	NNP
cord-270892-ycc3csyh	207	5	polymerase	polymerase	NN
cord-270892-ycc3csyh	207	6	transcription	transcription	NN
cord-270892-ycc3csyh	207	7	factors	factor	NNS
cord-270892-ycc3csyh	207	8	TFIID	TFIID	NNP
cord-270892-ycc3csyh	207	9	,	,	,
cord-270892-ycc3csyh	207	10	TFIIC	TFIIC	NNP
cord-270892-ycc3csyh	207	11	,	,	,
cord-270892-ycc3csyh	207	12	SL-1	SL-1	NNP
cord-270892-ycc3csyh	207	13	,	,	,
cord-270892-ycc3csyh	207	14	and	and	CC
cord-270892-ycc3csyh	207	15	UBF	UBF	NNP
cord-270892-ycc3csyh	207	16	.	.	.
cord-270892-ycc3csyh	208	1	98	98	CD
cord-270892-ycc3csyh	209	1	Therefore	therefore	RB
cord-270892-ycc3csyh	209	2	,	,	,
cord-270892-ycc3csyh	209	3	effective	effective	JJ
cord-270892-ycc3csyh	209	4	inhibition	inhibition	NN
cord-270892-ycc3csyh	209	5	of	of	IN
cord-270892-ycc3csyh	209	6	2A	2a	CD
cord-270892-ycc3csyh	209	7	pro	pro	NNP
cord-270892-ycc3csyh	209	8	and	and	CC
cord-270892-ycc3csyh	209	9	3C	3C	NNP
cord-270892-ycc3csyh	209	10	pro	pro	NNP
cord-270892-ycc3csyh	209	11	would	would	MD
cord-270892-ycc3csyh	209	12	not	not	RB
cord-270892-ycc3csyh	209	13	only	only	RB
cord-270892-ycc3csyh	209	14	inhibit	inhibit	VB
cord-270892-ycc3csyh	209	15	virus	virus	NN
cord-270892-ycc3csyh	209	16	replication	replication	NN
cord-270892-ycc3csyh	209	17	but	but	CC
cord-270892-ycc3csyh	209	18	could	could	MD
cord-270892-ycc3csyh	209	19	also	also	RB
cord-270892-ycc3csyh	209	20	prevent	prevent	VB
cord-270892-ycc3csyh	209	21	the	the	DT
cord-270892-ycc3csyh	209	22	shutoff	shutoff	NN
cord-270892-ycc3csyh	209	23	of	of	IN
cord-270892-ycc3csyh	209	24	cellular	cellular	JJ
cord-270892-ycc3csyh	209	25	protein	protein	NN
cord-270892-ycc3csyh	209	26	and	and	CC
cord-270892-ycc3csyh	209	27	RNA	RNA	NNP
cord-270892-ycc3csyh	209	28	synthesis	synthesis	NN
cord-270892-ycc3csyh	209	29	.	.	.
cord-270892-ycc3csyh	210	1	Moreover	moreover	RB
cord-270892-ycc3csyh	210	2	,	,	,
cord-270892-ycc3csyh	210	3	the	the	DT
cord-270892-ycc3csyh	210	4	active	active	JJ
cord-270892-ycc3csyh	210	5	site	site	NN
cord-270892-ycc3csyh	210	6	of	of	IN
cord-270892-ycc3csyh	210	7	proteinases	proteinases	NNP
cord-270892-ycc3csyh	210	8	is	be	VBZ
cord-270892-ycc3csyh	210	9	highly	highly	RB
cord-270892-ycc3csyh	210	10	conserved	conserve	VBN
cord-270892-ycc3csyh	210	11	among	among	IN
cord-270892-ycc3csyh	210	12	enterovirus	enterovirus	NN
cord-270892-ycc3csyh	210	13	serotypes	serotype	NNS
cord-270892-ycc3csyh	210	14	.	.	.
cord-270892-ycc3csyh	211	1	132	132	CD
cord-270892-ycc3csyh	212	1	This	this	DT
cord-270892-ycc3csyh	212	2	high	high	JJ
cord-270892-ycc3csyh	212	3	conservation	conservation	NN
cord-270892-ycc3csyh	212	4	in	in	IN
cord-270892-ycc3csyh	212	5	conjunction	conjunction	NN
cord-270892-ycc3csyh	212	6	with	with	IN
cord-270892-ycc3csyh	212	7	their	-PRON-	PRP$
cord-270892-ycc3csyh	212	8	important	important	JJ
cord-270892-ycc3csyh	212	9	role	role	NN
cord-270892-ycc3csyh	212	10	in	in	IN
cord-270892-ycc3csyh	212	11	virus	virus	NN
cord-270892-ycc3csyh	212	12	multiplication	multiplication	NN
cord-270892-ycc3csyh	212	13	predestines	predestine	VBZ
cord-270892-ycc3csyh	212	14	these	these	DT
cord-270892-ycc3csyh	212	15	enzymes	enzyme	NNS
cord-270892-ycc3csyh	212	16	as	as	IN
cord-270892-ycc3csyh	212	17	targets	target	NNS
cord-270892-ycc3csyh	212	18	for	for	IN
cord-270892-ycc3csyh	212	19	antiviral	antiviral	JJ
cord-270892-ycc3csyh	212	20	therapy	therapy	NN
cord-270892-ycc3csyh	212	21	.	.	.
cord-270892-ycc3csyh	213	1	The	the	DT
cord-270892-ycc3csyh	213	2	viral	viral	JJ
cord-270892-ycc3csyh	213	3	RNA	RNA	NNP
cord-270892-ycc3csyh	213	4	polymerase	polymerase	NN
cord-270892-ycc3csyh	213	5	3D	3D	NNP
cord-270892-ycc3csyh	213	6	(	(	-LRB-
cord-270892-ycc3csyh	213	7	3D	3D	NNP
cord-270892-ycc3csyh	213	8	pol	pol	NNP
cord-270892-ycc3csyh	213	9	)	)	-RRB-
cord-270892-ycc3csyh	213	10	represents	represent	VBZ
cord-270892-ycc3csyh	213	11	another	another	DT
cord-270892-ycc3csyh	213	12	very	very	RB
cord-270892-ycc3csyh	213	13	important	important	JJ
cord-270892-ycc3csyh	213	14	nonstructural	nonstructural	JJ
cord-270892-ycc3csyh	213	15	protein	protein	NN
cord-270892-ycc3csyh	213	16	of	of	IN
cord-270892-ycc3csyh	213	17	HRV	HRV	NNP
cord-270892-ycc3csyh	213	18	.	.	.
cord-270892-ycc3csyh	214	1	It	-PRON-	PRP
cord-270892-ycc3csyh	214	2	forms	form	VBZ
cord-270892-ycc3csyh	214	3	a	a	DT
cord-270892-ycc3csyh	214	4	complex	complex	NN
cord-270892-ycc3csyh	214	5	with	with	IN
cord-270892-ycc3csyh	214	6	both	both	DT
cord-270892-ycc3csyh	214	7	cellular	cellular	JJ
cord-270892-ycc3csyh	214	8	and	and	CC
cord-270892-ycc3csyh	214	9	viral	viral	JJ
cord-270892-ycc3csyh	214	10	proteins	protein	NNS
cord-270892-ycc3csyh	214	11	,	,	,
cord-270892-ycc3csyh	214	12	the	the	DT
cord-270892-ycc3csyh	214	13	RNA	RNA	NNP
cord-270892-ycc3csyh	214	14	replication	replication	NN
cord-270892-ycc3csyh	214	15	complex	complex	NN
cord-270892-ycc3csyh	214	16	.	.	.
cord-270892-ycc3csyh	215	1	98	98	CD
cord-270892-ycc3csyh	216	1	This	this	DT
cord-270892-ycc3csyh	216	2	enzyme	enzyme	NN
cord-270892-ycc3csyh	216	3	synthesizes	synthesize	VBZ
cord-270892-ycc3csyh	216	4	viral	viral	JJ
cord-270892-ycc3csyh	216	5	minus	minus	JJ
cord-270892-ycc3csyh	216	6	-	-	HYPH
cord-270892-ycc3csyh	216	7	strand	strand	NN
cord-270892-ycc3csyh	216	8	RNA	RNA	NNP
cord-270892-ycc3csyh	216	9	and	and	CC
cord-270892-ycc3csyh	216	10	uses	use	VBZ
cord-270892-ycc3csyh	216	11	it	-PRON-	PRP
cord-270892-ycc3csyh	216	12	as	as	IN
cord-270892-ycc3csyh	216	13	template	template	NN
cord-270892-ycc3csyh	216	14	strand	strand	NN
cord-270892-ycc3csyh	216	15	for	for	IN
cord-270892-ycc3csyh	216	16	the	the	DT
cord-270892-ycc3csyh	216	17	synthesis	synthesis	NN
cord-270892-ycc3csyh	216	18	of	of	IN
cord-270892-ycc3csyh	216	19	genomic	genomic	JJ
cord-270892-ycc3csyh	216	20	viral	viral	JJ
cord-270892-ycc3csyh	216	21	RNA	RNA	NNP
cord-270892-ycc3csyh	216	22	.	.	.
cord-270892-ycc3csyh	217	1	VPg	VPg	NNP
cord-270892-ycc3csyh	217	2	(	(	-LRB-
cord-270892-ycc3csyh	217	3	3B	3B	NNP
cord-270892-ycc3csyh	217	4	)	)	-RRB-
cord-270892-ycc3csyh	217	5	is	be	VBZ
cord-270892-ycc3csyh	217	6	the	the	DT
cord-270892-ycc3csyh	217	7	primer	primer	NN
cord-270892-ycc3csyh	217	8	for	for	IN
cord-270892-ycc3csyh	217	9	negative	negative	JJ
cord-270892-ycc3csyh	217	10	-	-	:
cord-270892-ycc3csyh	217	11	as	as	RB
cord-270892-ycc3csyh	217	12	well	well	RB
cord-270892-ycc3csyh	217	13	positive	positive	JJ
cord-270892-ycc3csyh	217	14	-	-	HYPH
cord-270892-ycc3csyh	217	15	strand	strand	NN
cord-270892-ycc3csyh	217	16	RNA	RNA	NNP
cord-270892-ycc3csyh	217	17	synthesis	synthesis	NN
cord-270892-ycc3csyh	217	18	.	.	.
cord-270892-ycc3csyh	218	1	Negative	negative	JJ
cord-270892-ycc3csyh	218	2	-	-	HYPH
cord-270892-ycc3csyh	218	3	strand	strand	NN
cord-270892-ycc3csyh	218	4	,	,	,
cord-270892-ycc3csyh	218	5	but	but	CC
cord-270892-ycc3csyh	218	6	not	not	RB
cord-270892-ycc3csyh	218	7	positive	positive	JJ
cord-270892-ycc3csyh	218	8	-	-	HYPH
cord-270892-ycc3csyh	218	9	strand	strand	NN
cord-270892-ycc3csyh	218	10	RNA	RNA	NNP
cord-270892-ycc3csyh	218	11	synthesis	synthesis	NN
cord-270892-ycc3csyh	218	12	,	,	,
cord-270892-ycc3csyh	218	13	is	be	VBZ
cord-270892-ycc3csyh	218	14	stimulated	stimulate	VBN
cord-270892-ycc3csyh	218	15	by	by	IN
cord-270892-ycc3csyh	218	16	2A	2a	CD
cord-270892-ycc3csyh	218	17	pro	pro	NN
cord-270892-ycc3csyh	218	18	.	.	.
cord-270892-ycc3csyh	219	1	Further	further	JJ
cord-270892-ycc3csyh	219	2	viral	viral	JJ
cord-270892-ycc3csyh	219	3	accessory	accessory	NN
cord-270892-ycc3csyh	219	4	proteins	protein	NNS
cord-270892-ycc3csyh	219	5	include	include	VBP
cord-270892-ycc3csyh	219	6	2B	2b	CD
cord-270892-ycc3csyh	219	7	,	,	,
cord-270892-ycc3csyh	219	8	2C	2C	NNP
cord-270892-ycc3csyh	219	9	,	,	,
cord-270892-ycc3csyh	219	10	2BC	2BC	NNP
cord-270892-ycc3csyh	219	11	,	,	,
cord-270892-ycc3csyh	219	12	and	and	CC
cord-270892-ycc3csyh	219	13	3AB	3AB	NNP
cord-270892-ycc3csyh	219	14	.	.	.
cord-270892-ycc3csyh	220	1	Besides	besides	IN
cord-270892-ycc3csyh	220	2	3D	3d	JJ
cord-270892-ycc3csyh	220	3	pol	pol	NN
cord-270892-ycc3csyh	220	4	these	these	DT
cord-270892-ycc3csyh	220	5	proteins	protein	NNS
cord-270892-ycc3csyh	220	6	can	can	MD
cord-270892-ycc3csyh	220	7	play	play	VB
cord-270892-ycc3csyh	220	8	an	an	DT
cord-270892-ycc3csyh	220	9	important	important	JJ
cord-270892-ycc3csyh	220	10	role	role	NN
cord-270892-ycc3csyh	220	11	in	in	IN
cord-270892-ycc3csyh	220	12	inhibition	inhibition	NN
cord-270892-ycc3csyh	220	13	of	of	IN
cord-270892-ycc3csyh	220	14	viral	viral	JJ
cord-270892-ycc3csyh	220	15	RNA	RNA	NNP
cord-270892-ycc3csyh	220	16	synthesis	synthesis	NN
cord-270892-ycc3csyh	220	17	by	by	IN
cord-270892-ycc3csyh	220	18	antiviral	antiviral	JJ
cord-270892-ycc3csyh	220	19	compounds	compound	NNS
cord-270892-ycc3csyh	220	20	.	.	.
cord-270892-ycc3csyh	221	1	In	in	IN
cord-270892-ycc3csyh	221	2	summary	summary	NN
cord-270892-ycc3csyh	221	3	,	,	,
cord-270892-ycc3csyh	221	4	the	the	DT
cord-270892-ycc3csyh	221	5	knowledge	knowledge	NN
cord-270892-ycc3csyh	221	6	of	of	IN
cord-270892-ycc3csyh	221	7	the	the	DT
cord-270892-ycc3csyh	221	8	structure	structure	NN
cord-270892-ycc3csyh	221	9	of	of	IN
cord-270892-ycc3csyh	221	10	the	the	DT
cord-270892-ycc3csyh	221	11	viral	viral	JJ
cord-270892-ycc3csyh	221	12	capsid	capsid	NN
cord-270892-ycc3csyh	221	13	,	,	,
cord-270892-ycc3csyh	221	14	proteases	protease	NNS
cord-270892-ycc3csyh	221	15	,	,	,
cord-270892-ycc3csyh	221	16	and	and	CC
cord-270892-ycc3csyh	221	17	polymerase	polymerase	NN
cord-270892-ycc3csyh	221	18	and	and	CC
cord-270892-ycc3csyh	221	19	their	-PRON-	PRP$
cord-270892-ycc3csyh	221	20	important	important	JJ
cord-270892-ycc3csyh	221	21	function	function	NN
cord-270892-ycc3csyh	221	22	in	in	IN
cord-270892-ycc3csyh	221	23	the	the	DT
cord-270892-ycc3csyh	221	24	viral	viral	JJ
cord-270892-ycc3csyh	221	25	life	life	NN
cord-270892-ycc3csyh	221	26	cycle	cycle	NN
cord-270892-ycc3csyh	221	27	predestine	predestine	VBP
cord-270892-ycc3csyh	221	28	these	these	DT
cord-270892-ycc3csyh	221	29	proteins	protein	NNS
cord-270892-ycc3csyh	221	30	as	as	IN
cord-270892-ycc3csyh	221	31	potential	potential	JJ
cord-270892-ycc3csyh	221	32	anti	anti	JJ
cord-270892-ycc3csyh	221	33	-	-	JJ
cord-270892-ycc3csyh	221	34	HRV	HRV	NNP
cord-270892-ycc3csyh	221	35	targets	target	NNS
cord-270892-ycc3csyh	221	36	.	.	.
cord-270892-ycc3csyh	222	1	HRV	HRV	NNP
cord-270892-ycc3csyh	222	2	grow	grow	VB
cord-270892-ycc3csyh	222	3	in	in	IN
cord-270892-ycc3csyh	222	4	several	several	JJ
cord-270892-ycc3csyh	222	5	human	human	NN
cord-270892-ycc3csyh	222	6	and	and	CC
cord-270892-ycc3csyh	222	7	some	some	DT
cord-270892-ycc3csyh	222	8	primate	primate	NN
cord-270892-ycc3csyh	222	9	cells	cell	NNS
cord-270892-ycc3csyh	222	10	expressing	express	VBG
cord-270892-ycc3csyh	222	11	the	the	DT
cord-270892-ycc3csyh	222	12	minor	minor	JJ
cord-270892-ycc3csyh	222	13	group	group	NN
cord-270892-ycc3csyh	222	14	LDL	LDL	NNP
cord-270892-ycc3csyh	222	15	receptors	receptor	NNS
cord-270892-ycc3csyh	222	16	and/or	and/or	CC
cord-270892-ycc3csyh	222	17	the	the	DT
cord-270892-ycc3csyh	222	18	major	major	JJ
cord-270892-ycc3csyh	222	19	group	group	NN
cord-270892-ycc3csyh	222	20	receptor	receptor	NN
cord-270892-ycc3csyh	222	21	ICAM-1	ICAM-1	NNP
cord-270892-ycc3csyh	222	22	.	.	.
cord-270892-ycc3csyh	223	1	Human	human	JJ
cord-270892-ycc3csyh	223	2	cells	cell	NNS
cord-270892-ycc3csyh	223	3	susceptible	susceptible	JJ
cord-270892-ycc3csyh	223	4	to	to	IN
cord-270892-ycc3csyh	223	5	HRV	HRV	NNP
cord-270892-ycc3csyh	223	6	infections	infection	NNS
cord-270892-ycc3csyh	223	7	include	include	VBP
cord-270892-ycc3csyh	223	8	embryonic	embryonic	JJ
cord-270892-ycc3csyh	223	9	kidney	kidney	NN
cord-270892-ycc3csyh	223	10	,	,	,
cord-270892-ycc3csyh	223	11	amnion	amnion	NN
cord-270892-ycc3csyh	223	12	,	,	,
cord-270892-ycc3csyh	223	13	diploid	diploid	JJ
cord-270892-ycc3csyh	223	14	fibroblasts	fibroblast	NNS
cord-270892-ycc3csyh	223	15	from	from	IN
cord-270892-ycc3csyh	223	16	embryonic	embryonic	JJ
cord-270892-ycc3csyh	223	17	lung	lung	NN
cord-270892-ycc3csyh	223	18	,	,	,
cord-270892-ycc3csyh	223	19	tonsil	tonsil	NN
cord-270892-ycc3csyh	223	20	,	,	,
cord-270892-ycc3csyh	223	21	liver	liver	NN
cord-270892-ycc3csyh	223	22	,	,	,
cord-270892-ycc3csyh	223	23	intestine	intestine	NN
cord-270892-ycc3csyh	223	24	,	,	,
cord-270892-ycc3csyh	223	25	and	and	CC
cord-270892-ycc3csyh	223	26	skin	skin	NN
cord-270892-ycc3csyh	223	27	,	,	,
cord-270892-ycc3csyh	223	28	adult	adult	NN
cord-270892-ycc3csyh	223	29	fibroblast	fibroblast	NN
cord-270892-ycc3csyh	223	30	lines	line	NNS
cord-270892-ycc3csyh	223	31	from	from	IN
cord-270892-ycc3csyh	223	32	aorta	aorta	NN
cord-270892-ycc3csyh	223	33	and	and	CC
cord-270892-ycc3csyh	223	34	gingival	gingival	NN
cord-270892-ycc3csyh	223	35	and	and	CC
cord-270892-ycc3csyh	223	36	the	the	DT
cord-270892-ycc3csyh	223	37	KB	KB	NNP
cord-270892-ycc3csyh	223	38	,	,	,
cord-270892-ycc3csyh	223	39	HEP-2	HEP-2	NNP
cord-270892-ycc3csyh	223	40	,	,	,
cord-270892-ycc3csyh	223	41	and	and	CC
cord-270892-ycc3csyh	223	42	HeLa	HeLa	NNP
cord-270892-ycc3csyh	223	43	continuous	continuous	JJ
cord-270892-ycc3csyh	223	44	cell	cell	NN
cord-270892-ycc3csyh	223	45	lines	line	NNS
cord-270892-ycc3csyh	223	46	.	.	.
cord-270892-ycc3csyh	224	1	133	133	CD
cord-270892-ycc3csyh	225	1	But	but	CC
cord-270892-ycc3csyh	225	2	,	,	,
cord-270892-ycc3csyh	225	3	the	the	DT
cord-270892-ycc3csyh	225	4	susceptibility	susceptibility	NN
cord-270892-ycc3csyh	225	5	of	of	IN
cord-270892-ycc3csyh	225	6	HeLa	HeLa	NNP
cord-270892-ycc3csyh	225	7	cells	cell	NNS
cord-270892-ycc3csyh	225	8	and	and	CC
cord-270892-ycc3csyh	225	9	human	human	JJ
cord-270892-ycc3csyh	225	10	fibroblasts	fibroblast	NNS
cord-270892-ycc3csyh	225	11	to	to	IN
cord-270892-ycc3csyh	225	12	virus	virus	NN
cord-270892-ycc3csyh	225	13	infection	infection	NN
cord-270892-ycc3csyh	225	14	may	may	MD
cord-270892-ycc3csyh	225	15	vary	vary	VB
cord-270892-ycc3csyh	225	16	.	.	.
cord-270892-ycc3csyh	226	1	32	32	CD
cord-270892-ycc3csyh	226	2	HRV	HRV	NNP
cord-270892-ycc3csyh	226	3	multiplication	multiplication	NN
cord-270892-ycc3csyh	226	4	also	also	RB
cord-270892-ycc3csyh	226	5	occurs	occur	VBZ
cord-270892-ycc3csyh	226	6	in	in	IN
cord-270892-ycc3csyh	226	7	primary	primary	JJ
cord-270892-ycc3csyh	226	8	human	human	JJ
cord-270892-ycc3csyh	226	9	airway	airway	NN
cord-270892-ycc3csyh	226	10	fibroblasts	fibroblast	NNS
cord-270892-ycc3csyh	226	11	134	134	CD
cord-270892-ycc3csyh	226	12	and	and	CC
cord-270892-ycc3csyh	226	13	differentiated	differentiate	VBN
cord-270892-ycc3csyh	226	14	bronchial	bronchial	JJ
cord-270892-ycc3csyh	226	15	epithelium	epithelium	NN
cord-270892-ycc3csyh	226	16	.	.	.
cord-270892-ycc3csyh	227	1	77	77	CD
cord-270892-ycc3csyh	227	2	,	,	,
cord-270892-ycc3csyh	227	3	78	78	CD
cord-270892-ycc3csyh	227	4	,	,	,
cord-270892-ycc3csyh	227	5	135	135	CD
cord-270892-ycc3csyh	228	1	The	the	DT
cord-270892-ycc3csyh	228	2	proportion	proportion	NN
cord-270892-ycc3csyh	228	3	of	of	IN
cord-270892-ycc3csyh	228	4	infectible	infectible	JJ
cord-270892-ycc3csyh	228	5	epithelial	epithelial	JJ
cord-270892-ycc3csyh	228	6	cells	cell	NNS
cord-270892-ycc3csyh	228	7	was	be	VBD
cord-270892-ycc3csyh	228	8	shown	show	VBN
cord-270892-ycc3csyh	228	9	to	to	TO
cord-270892-ycc3csyh	228	10	be	be	VB
cord-270892-ycc3csyh	228	11	between	between	IN
cord-270892-ycc3csyh	228	12	3	3	CD
cord-270892-ycc3csyh	228	13	and	and	CC
cord-270892-ycc3csyh	228	14	10	10	CD
cord-270892-ycc3csyh	228	15	%	%	NN
cord-270892-ycc3csyh	228	16	.	.	.
cord-270892-ycc3csyh	229	1	77	77	CD
cord-270892-ycc3csyh	229	2	,	,	,
cord-270892-ycc3csyh	229	3	135	135	CD
cord-270892-ycc3csyh	230	1	But	but	CC
cord-270892-ycc3csyh	230	2	,	,	,
cord-270892-ycc3csyh	230	3	enhanced	enhanced	JJ
cord-270892-ycc3csyh	230	4	levels	level	NNS
cord-270892-ycc3csyh	230	5	of	of	IN
cord-270892-ycc3csyh	230	6	viral	viral	JJ
cord-270892-ycc3csyh	230	7	production	production	NN
cord-270892-ycc3csyh	230	8	were	be	VBD
cord-270892-ycc3csyh	230	9	detected	detect	VBN
cord-270892-ycc3csyh	230	10	in	in	IN
cord-270892-ycc3csyh	230	11	poorly	poorly	RB
cord-270892-ycc3csyh	230	12	differentiated	differentiate	VBN
cord-270892-ycc3csyh	230	13	in	in	IN
cord-270892-ycc3csyh	230	14	comparison	comparison	NN
cord-270892-ycc3csyh	230	15	to	to	IN
cord-270892-ycc3csyh	230	16	differentiated	differentiated	JJ
cord-270892-ycc3csyh	230	17	epithelial	epithelial	JJ
cord-270892-ycc3csyh	230	18	cells	cell	NNS
cord-270892-ycc3csyh	230	19	.	.	.
cord-270892-ycc3csyh	231	1	136	136	CD
cord-270892-ycc3csyh	232	1	The	the	DT
cord-270892-ycc3csyh	232	2	degree	degree	NN
cord-270892-ycc3csyh	232	3	of	of	IN
cord-270892-ycc3csyh	232	4	viral	viral	JJ
cord-270892-ycc3csyh	232	5	infection	infection	NN
cord-270892-ycc3csyh	232	6	correlated	correlate	VBN
cord-270892-ycc3csyh	232	7	with	with	IN
cord-270892-ycc3csyh	232	8	IL-6	IL-6	NNP
cord-270892-ycc3csyh	232	9	and	and	CC
cord-270892-ycc3csyh	233	1	IL-8	IL-8	NNP
cord-270892-ycc3csyh	233	2	induction	induction	NN
cord-270892-ycc3csyh	233	3	in	in	IN
cord-270892-ycc3csyh	233	4	these	these	DT
cord-270892-ycc3csyh	233	5	cells	cell	NNS
cord-270892-ycc3csyh	233	6	Virus	virus	NN
cord-270892-ycc3csyh	233	7	growth	growth	NN
cord-270892-ycc3csyh	233	8	causes	cause	VBZ
cord-270892-ycc3csyh	233	9	a	a	DT
cord-270892-ycc3csyh	233	10	typical	typical	JJ
cord-270892-ycc3csyh	233	11	CPE	CPE	NNP
cord-270892-ycc3csyh	233	12	characterized	characterize	VBN
cord-270892-ycc3csyh	233	13	by	by	IN
cord-270892-ycc3csyh	233	14	ballooning	ballooning	NN
cord-270892-ycc3csyh	233	15	,	,	,
cord-270892-ycc3csyh	233	16	refractiveness	refractiveness	JJ
cord-270892-ycc3csyh	233	17	,	,	,
cord-270892-ycc3csyh	233	18	granularity	granularity	NN
cord-270892-ycc3csyh	233	19	,	,	,
cord-270892-ycc3csyh	233	20	and	and	CC
cord-270892-ycc3csyh	233	21	shrinkage	shrinkage	NN
cord-270892-ycc3csyh	233	22	of	of	IN
cord-270892-ycc3csyh	233	23	infected	infected	JJ
cord-270892-ycc3csyh	233	24	cells	cell	NNS
cord-270892-ycc3csyh	233	25	.	.	.
cord-270892-ycc3csyh	234	1	The	the	DT
cord-270892-ycc3csyh	234	2	HRV	HRV	NNP
cord-270892-ycc3csyh	234	3	-	-	HYPH
cord-270892-ycc3csyh	234	4	induced	induce	VBN
cord-270892-ycc3csyh	234	5	CPE	CPE	NNP
cord-270892-ycc3csyh	234	6	,	,	,
cord-270892-ycc3csyh	234	7	infectious	infectious	JJ
cord-270892-ycc3csyh	234	8	virus	virus	NN
cord-270892-ycc3csyh	234	9	titers	titer	NNS
cord-270892-ycc3csyh	234	10	,	,	,
cord-270892-ycc3csyh	234	11	viral	viral	JJ
cord-270892-ycc3csyh	234	12	protein	protein	NN
cord-270892-ycc3csyh	234	13	expression	expression	NN
cord-270892-ycc3csyh	234	14	,	,	,
cord-270892-ycc3csyh	234	15	and	and	CC
cord-270892-ycc3csyh	234	16	RNA	RNA	NNP
cord-270892-ycc3csyh	234	17	synthesis	synthesis	NN
cord-270892-ycc3csyh	234	18	can	can	MD
cord-270892-ycc3csyh	234	19	be	be	VB
cord-270892-ycc3csyh	234	20	chosen	choose	VBN
cord-270892-ycc3csyh	234	21	as	as	IN
cord-270892-ycc3csyh	234	22	parameters	parameter	NNS
cord-270892-ycc3csyh	234	23	to	to	TO
cord-270892-ycc3csyh	234	24	evaluate	evaluate	VB
cord-270892-ycc3csyh	234	25	the	the	DT
cord-270892-ycc3csyh	234	26	anti	anti	JJ
cord-270892-ycc3csyh	234	27	-	-	JJ
cord-270892-ycc3csyh	234	28	HRV	HRV	NNP
cord-270892-ycc3csyh	234	29	activity	activity	NN
cord-270892-ycc3csyh	234	30	of	of	IN
cord-270892-ycc3csyh	234	31	compounds	compound	NNS
cord-270892-ycc3csyh	234	32	in	in	IN
cord-270892-ycc3csyh	234	33	cell	cell	NN
cord-270892-ycc3csyh	234	34	-	-	HYPH
cord-270892-ycc3csyh	234	35	culture	culture	NN
cord-270892-ycc3csyh	234	36	based	base	VBN
cord-270892-ycc3csyh	234	37	assays	assay	NNS
cord-270892-ycc3csyh	234	38	.	.	.
cord-270892-ycc3csyh	235	1	There	there	EX
cord-270892-ycc3csyh	235	2	are	be	VBP
cord-270892-ycc3csyh	235	3	several	several	JJ
cord-270892-ycc3csyh	235	4	methods	method	NNS
cord-270892-ycc3csyh	235	5	for	for	IN
cord-270892-ycc3csyh	235	6	antiviral	antiviral	JJ
cord-270892-ycc3csyh	235	7	screening	screening	NN
cord-270892-ycc3csyh	235	8	against	against	IN
cord-270892-ycc3csyh	235	9	HRV	HRV	NNP
cord-270892-ycc3csyh	235	10	.	.	.
cord-270892-ycc3csyh	236	1	The	the	DT
cord-270892-ycc3csyh	236	2	plaque	plaque	NN
cord-270892-ycc3csyh	236	3	reduction	reduction	NN
cord-270892-ycc3csyh	236	4	assay	assay	NN
cord-270892-ycc3csyh	236	5	has	have	VBZ
cord-270892-ycc3csyh	236	6	been	be	VBN
cord-270892-ycc3csyh	236	7	traditionally	traditionally	RB
cord-270892-ycc3csyh	236	8	performed	perform	VBN
cord-270892-ycc3csyh	236	9	and	and	CC
cord-270892-ycc3csyh	236	10	accepted	accept	VBN
cord-270892-ycc3csyh	236	11	as	as	IN
cord-270892-ycc3csyh	236	12	the	the	DT
cord-270892-ycc3csyh	236	13	'	'	''
cord-270892-ycc3csyh	236	14	'	'	``
cord-270892-ycc3csyh	236	15	gold	gold	NN
cord-270892-ycc3csyh	236	16	standard	standard	NN
cord-270892-ycc3csyh	236	17	'	'	''
cord-270892-ycc3csyh	236	18	'	'	''
cord-270892-ycc3csyh	236	19	in	in	IN
cord-270892-ycc3csyh	236	20	antiviral	antiviral	JJ
cord-270892-ycc3csyh	236	21	testing	testing	NN
cord-270892-ycc3csyh	236	22	.	.	.
cord-270892-ycc3csyh	237	1	[	[	-LRB-
cord-270892-ycc3csyh	237	2	137	137	CD
cord-270892-ycc3csyh	237	3	]	]	-RRB-
cord-270892-ycc3csyh	237	4	[	[	-LRB-
cord-270892-ycc3csyh	237	5	138	138	CD
cord-270892-ycc3csyh	237	6	]	]	-RRB-
cord-270892-ycc3csyh	238	1	[	[	-LRB-
cord-270892-ycc3csyh	238	2	139	139	CD
cord-270892-ycc3csyh	238	3	]	]	-RRB-
cord-270892-ycc3csyh	239	1	However	however	RB
cord-270892-ycc3csyh	239	2	,	,	,
cord-270892-ycc3csyh	239	3	this	this	DT
cord-270892-ycc3csyh	239	4	test	test	NN
cord-270892-ycc3csyh	239	5	is	be	VBZ
cord-270892-ycc3csyh	239	6	laborious	laborious	JJ
cord-270892-ycc3csyh	239	7	,	,	,
cord-270892-ycc3csyh	239	8	time	time	NN
cord-270892-ycc3csyh	239	9	consuming	consume	VBG
cord-270892-ycc3csyh	239	10	,	,	,
cord-270892-ycc3csyh	239	11	and	and	CC
cord-270892-ycc3csyh	239	12	the	the	DT
cord-270892-ycc3csyh	239	13	evaluation	evaluation	NN
cord-270892-ycc3csyh	239	14	is	be	VBZ
cord-270892-ycc3csyh	239	15	subjective	subjective	JJ
cord-270892-ycc3csyh	239	16	.	.	.
cord-270892-ycc3csyh	240	1	Therefore	therefore	RB
cord-270892-ycc3csyh	240	2	,	,	,
cord-270892-ycc3csyh	240	3	it	-PRON-	PRP
cord-270892-ycc3csyh	240	4	is	be	VBZ
cord-270892-ycc3csyh	240	5	not	not	RB
cord-270892-ycc3csyh	240	6	suited	suit	VBN
cord-270892-ycc3csyh	240	7	for	for	IN
cord-270892-ycc3csyh	240	8	the	the	DT
cord-270892-ycc3csyh	240	9	routine	routine	JJ
cord-270892-ycc3csyh	240	10	antiviral	antiviral	JJ
cord-270892-ycc3csyh	240	11	testing	testing	NN
cord-270892-ycc3csyh	240	12	.	.	.
cord-270892-ycc3csyh	241	1	It	-PRON-	PRP
cord-270892-ycc3csyh	241	2	was	be	VBD
cord-270892-ycc3csyh	241	3	more	more	RBR
cord-270892-ycc3csyh	241	4	and	and	CC
cord-270892-ycc3csyh	241	5	more	more	RBR
cord-270892-ycc3csyh	241	6	replaced	replace	VBN
cord-270892-ycc3csyh	241	7	by	by	IN
cord-270892-ycc3csyh	241	8	methods	method	NNS
cord-270892-ycc3csyh	241	9	based	base	VBN
cord-270892-ycc3csyh	241	10	on	on	IN
cord-270892-ycc3csyh	241	11	quantification	quantification	NN
cord-270892-ycc3csyh	241	12	of	of	IN
cord-270892-ycc3csyh	241	13	protection	protection	NN
cord-270892-ycc3csyh	241	14	from	from	IN
cord-270892-ycc3csyh	241	15	virus	virus	NN
cord-270892-ycc3csyh	241	16	-	-	HYPH
cord-270892-ycc3csyh	241	17	induced	induce	VBN
cord-270892-ycc3csyh	241	18	CPE	CPE	NNP
cord-270892-ycc3csyh	241	19	after	after	IN
cord-270892-ycc3csyh	241	20	drug	drug	NN
cord-270892-ycc3csyh	241	21	treatment	treatment	NN
cord-270892-ycc3csyh	241	22	.	.	.
cord-270892-ycc3csyh	242	1	So	so	RB
cord-270892-ycc3csyh	242	2	,	,	,
cord-270892-ycc3csyh	242	3	the	the	DT
cord-270892-ycc3csyh	242	4	CPE	CPE	NNP
cord-270892-ycc3csyh	242	5	in	in	IN
cord-270892-ycc3csyh	242	6	sample	sample	NN
cord-270892-ycc3csyh	242	7	-	-	HYPH
cord-270892-ycc3csyh	242	8	treated	treat	VBN
cord-270892-ycc3csyh	242	9	and	and	CC
cord-270892-ycc3csyh	242	10	untreated	untreated	JJ
cord-270892-ycc3csyh	242	11	cells	cell	NNS
cord-270892-ycc3csyh	242	12	has	have	VBZ
cord-270892-ycc3csyh	242	13	been	be	VBN
cord-270892-ycc3csyh	242	14	compared	compare	VBN
cord-270892-ycc3csyh	242	15	by	by	IN
cord-270892-ycc3csyh	242	16	light	light	JJ
cord-270892-ycc3csyh	242	17	microscopy	microscopy	NNS
cord-270892-ycc3csyh	242	18	.	.	.
cord-270892-ycc3csyh	243	1	137	137	CD
cord-270892-ycc3csyh	243	2	,	,	,
cord-270892-ycc3csyh	243	3	140	140	CD
cord-270892-ycc3csyh	243	4	,	,	,
cord-270892-ycc3csyh	243	5	141	141	CD
cord-270892-ycc3csyh	244	1	But	but	CC
cord-270892-ycc3csyh	244	2	this	this	DT
cord-270892-ycc3csyh	244	3	evaluation	evaluation	NN
cord-270892-ycc3csyh	244	4	is	be	VBZ
cord-270892-ycc3csyh	244	5	also	also	RB
cord-270892-ycc3csyh	244	6	subjective	subjective	JJ
cord-270892-ycc3csyh	244	7	.	.	.
cord-270892-ycc3csyh	245	1	Another	another	DT
cord-270892-ycc3csyh	245	2	more	more	RBR
cord-270892-ycc3csyh	245	3	objective	objective	JJ
cord-270892-ycc3csyh	245	4	approach	approach	NN
cord-270892-ycc3csyh	245	5	is	be	VBZ
cord-270892-ycc3csyh	245	6	the	the	DT
cord-270892-ycc3csyh	245	7	spectrophotometric	spectrophotometric	JJ
cord-270892-ycc3csyh	245	8	quantification	quantification	NN
cord-270892-ycc3csyh	245	9	of	of	IN
cord-270892-ycc3csyh	245	10	CPE	CPE	NNP
cord-270892-ycc3csyh	245	11	results	result	NNS
cord-270892-ycc3csyh	245	12	in	in	IN
cord-270892-ycc3csyh	245	13	neutral	neutral	JJ
cord-270892-ycc3csyh	245	14	red	red	JJ
cord-270892-ycc3csyh	245	15	or	or	CC
cord-270892-ycc3csyh	245	16	crystal	crystal	NN
cord-270892-ycc3csyh	245	17	violet	violet	NN
cord-270892-ycc3csyh	245	18	uptake	uptake	NN
cord-270892-ycc3csyh	245	19	assays	assay	NNS
cord-270892-ycc3csyh	245	20	,	,	,
cord-270892-ycc3csyh	245	21	12,141	12,141	CD
cord-270892-ycc3csyh	245	22	-	-	SYM
cord-270892-ycc3csyh	245	23	144	144	CD
cord-270892-ycc3csyh	245	24	and	and	CC
cord-270892-ycc3csyh	245	25	the	the	DT
cord-270892-ycc3csyh	245	26	tetrazolium	tetrazolium	NNP
cord-270892-ycc3csyh	245	27	dye	dye	NN
cord-270892-ycc3csyh	245	28	reduction	reduction	NN
cord-270892-ycc3csyh	245	29	method	method	NN
cord-270892-ycc3csyh	245	30	.	.	.
cord-270892-ycc3csyh	246	1	132	132	CD
cord-270892-ycc3csyh	246	2	,	,	,
cord-270892-ycc3csyh	246	3	145	145	CD
cord-270892-ycc3csyh	247	1	It	-PRON-	PRP
cord-270892-ycc3csyh	247	2	allows	allow	VBZ
cord-270892-ycc3csyh	247	3	an	an	DT
cord-270892-ycc3csyh	247	4	excellent	excellent	JJ
cord-270892-ycc3csyh	247	5	and	and	CC
cord-270892-ycc3csyh	247	6	rapid	rapid	JJ
cord-270892-ycc3csyh	247	7	antiviral	antiviral	JJ
cord-270892-ycc3csyh	247	8	screening	screening	NN
cord-270892-ycc3csyh	247	9	of	of	IN
cord-270892-ycc3csyh	247	10	large	large	JJ
cord-270892-ycc3csyh	247	11	numbers	number	NNS
cord-270892-ycc3csyh	247	12	of	of	IN
cord-270892-ycc3csyh	247	13	compounds	compound	NNS
cord-270892-ycc3csyh	247	14	using	use	VBG
cord-270892-ycc3csyh	247	15	small	small	JJ
cord-270892-ycc3csyh	247	16	amounts	amount	NNS
cord-270892-ycc3csyh	247	17	of	of	IN
cord-270892-ycc3csyh	247	18	extracts	extract	NNS
cord-270892-ycc3csyh	247	19	,	,	,
cord-270892-ycc3csyh	247	20	natural	natural	JJ
cord-270892-ycc3csyh	247	21	,	,	,
cord-270892-ycc3csyh	247	22	or	or	CC
cord-270892-ycc3csyh	247	23	synthetic	synthetic	JJ
cord-270892-ycc3csyh	247	24	compounds	compound	NNS
cord-270892-ycc3csyh	247	25	.	.	.
cord-270892-ycc3csyh	248	1	Active	active	JJ
cord-270892-ycc3csyh	248	2	samples	sample	NNS
cord-270892-ycc3csyh	248	3	can	can	MD
cord-270892-ycc3csyh	248	4	be	be	VB
cord-270892-ycc3csyh	248	5	scheduled	schedule	VBN
cord-270892-ycc3csyh	248	6	for	for	IN
cord-270892-ycc3csyh	248	7	additional	additional	JJ
cord-270892-ycc3csyh	248	8	testing	testing	NN
cord-270892-ycc3csyh	248	9	using	use	VBG
cord-270892-ycc3csyh	248	10	other	other	JJ
cord-270892-ycc3csyh	248	11	assays	assay	NNS
cord-270892-ycc3csyh	249	1	e.g.	e.g.	IN
cord-270892-ycc3csyh	249	2	virus	virus	NN
cord-270892-ycc3csyh	249	3	yield	yield	NN
cord-270892-ycc3csyh	249	4	or	or	CC
cord-270892-ycc3csyh	249	5	plaque	plaque	NN
cord-270892-ycc3csyh	249	6	reduction	reduction	NN
cord-270892-ycc3csyh	249	7	assays	assay	NNS
cord-270892-ycc3csyh	249	8	,	,	,
cord-270892-ycc3csyh	249	9	and	and	CC
cord-270892-ycc3csyh	249	10	for	for	IN
cord-270892-ycc3csyh	249	11	studies	study	NNS
cord-270892-ycc3csyh	249	12	on	on	IN
cord-270892-ycc3csyh	249	13	the	the	DT
cord-270892-ycc3csyh	249	14	mechanism	mechanism	NN
cord-270892-ycc3csyh	249	15	of	of	IN
cord-270892-ycc3csyh	249	16	action	action	NN
cord-270892-ycc3csyh	249	17	.	.	.
cord-270892-ycc3csyh	250	1	The	the	DT
cord-270892-ycc3csyh	250	2	activity	activity	NN
cord-270892-ycc3csyh	250	3	of	of	IN
cord-270892-ycc3csyh	250	4	potential	potential	JJ
cord-270892-ycc3csyh	250	5	antiviral	antiviral	JJ
cord-270892-ycc3csyh	250	6	drugs	drug	NNS
cord-270892-ycc3csyh	250	7	has	have	VBZ
cord-270892-ycc3csyh	250	8	to	to	TO
cord-270892-ycc3csyh	250	9	be	be	VB
cord-270892-ycc3csyh	250	10	approved	approve	VBN
cord-270892-ycc3csyh	250	11	in	in	IN
cord-270892-ycc3csyh	250	12	vivo	vivo	NN
cord-270892-ycc3csyh	250	13	.	.	.
cord-270892-ycc3csyh	251	1	Because	because	IN
cord-270892-ycc3csyh	251	2	of	of	IN
cord-270892-ycc3csyh	251	3	the	the	DT
cord-270892-ycc3csyh	251	4	high	high	JJ
cord-270892-ycc3csyh	251	5	degree	degree	NN
cord-270892-ycc3csyh	251	6	of	of	IN
cord-270892-ycc3csyh	251	7	species	species	NN
cord-270892-ycc3csyh	251	8	-	-	HYPH
cord-270892-ycc3csyh	251	9	specific	specific	JJ
cord-270892-ycc3csyh	251	10	variations	variation	NNS
cord-270892-ycc3csyh	251	11	in	in	IN
cord-270892-ycc3csyh	251	12	ICAM-1	icam-1	NN
cord-270892-ycc3csyh	251	13	preventing	prevent	VBG
cord-270892-ycc3csyh	251	14	infection	infection	NN
cord-270892-ycc3csyh	251	15	by	by	IN
cord-270892-ycc3csyh	251	16	major	major	JJ
cord-270892-ycc3csyh	251	17	group	group	NN
cord-270892-ycc3csyh	251	18	HRV	HRV	NNP
cord-270892-ycc3csyh	251	19	,	,	,
cord-270892-ycc3csyh	251	20	practical	practical	JJ
cord-270892-ycc3csyh	251	21	animal	animal	NN
cord-270892-ycc3csyh	251	22	models	model	NNS
cord-270892-ycc3csyh	251	23	have	have	VBP
cord-270892-ycc3csyh	251	24	been	be	VBN
cord-270892-ycc3csyh	251	25	absent	absent	JJ
cord-270892-ycc3csyh	251	26	for	for	IN
cord-270892-ycc3csyh	251	27	a	a	DT
cord-270892-ycc3csyh	251	28	long	long	JJ
cord-270892-ycc3csyh	251	29	time	time	NN
cord-270892-ycc3csyh	251	30	.	.	.
cord-270892-ycc3csyh	252	1	Chimpanzees	chimpanzee	NNS
cord-270892-ycc3csyh	252	2	were	be	VBD
cord-270892-ycc3csyh	252	3	infected	infect	VBN
cord-270892-ycc3csyh	252	4	with	with	IN
cord-270892-ycc3csyh	252	5	several	several	JJ
cord-270892-ycc3csyh	252	6	HRV	HRV	NNP
cord-270892-ycc3csyh	252	7	serotypes	serotype	NNS
cord-270892-ycc3csyh	252	8	but	but	CC
cord-270892-ycc3csyh	252	9	without	without	IN
cord-270892-ycc3csyh	252	10	developing	develop	VBG
cord-270892-ycc3csyh	252	11	clinical	clinical	JJ
cord-270892-ycc3csyh	252	12	signs	sign	NNS
cord-270892-ycc3csyh	252	13	.	.	.
cord-270892-ycc3csyh	253	1	133	133	CD
cord-270892-ycc3csyh	253	2	HRV	HRV	NNP
cord-270892-ycc3csyh	253	3	do	do	VBP
cord-270892-ycc3csyh	253	4	not	not	RB
cord-270892-ycc3csyh	253	5	induce	induce	VB
cord-270892-ycc3csyh	253	6	infection	infection	NN
cord-270892-ycc3csyh	253	7	in	in	IN
cord-270892-ycc3csyh	253	8	rabbits	rabbit	NNS
cord-270892-ycc3csyh	253	9	,	,	,
cord-270892-ycc3csyh	253	10	guinea	guinea	NN
cord-270892-ycc3csyh	253	11	pigs	pig	NNS
cord-270892-ycc3csyh	253	12	,	,	,
cord-270892-ycc3csyh	253	13	and	and	CC
cord-270892-ycc3csyh	253	14	weanling	weanle	VBG
cord-270892-ycc3csyh	253	15	mice	mouse	NNS
cord-270892-ycc3csyh	253	16	injected	inject	VBD
cord-270892-ycc3csyh	253	17	with	with	IN
cord-270892-ycc3csyh	253	18	HRV	HRV	NNP
cord-270892-ycc3csyh	253	19	by	by	IN
cord-270892-ycc3csyh	253	20	different	different	JJ
cord-270892-ycc3csyh	253	21	routes	route	NNS
cord-270892-ycc3csyh	253	22	.	.	.
cord-270892-ycc3csyh	254	1	One	one	CD
cord-270892-ycc3csyh	254	2	minor	minor	JJ
cord-270892-ycc3csyh	254	3	group	group	NN
cord-270892-ycc3csyh	254	4	HRV	HRV	NNP
cord-270892-ycc3csyh	254	5	,	,	,
cord-270892-ycc3csyh	254	6	serotype	serotype	NN
cord-270892-ycc3csyh	254	7	2	2	CD
cord-270892-ycc3csyh	254	8	,	,	,
cord-270892-ycc3csyh	254	9	was	be	VBD
cord-270892-ycc3csyh	254	10	adapted	adapt	VBN
cord-270892-ycc3csyh	254	11	to	to	TO
cord-270892-ycc3csyh	254	12	grow	grow	VB
cord-270892-ycc3csyh	254	13	in	in	IN
cord-270892-ycc3csyh	254	14	mouse	mouse	NN
cord-270892-ycc3csyh	254	15	fibroblasts	fibroblast	NNS
cord-270892-ycc3csyh	254	16	and	and	CC
cord-270892-ycc3csyh	254	17	used	use	VBN
cord-270892-ycc3csyh	254	18	in	in	IN
cord-270892-ycc3csyh	254	19	a	a	DT
cord-270892-ycc3csyh	254	20	mouse	mouse	NN
cord-270892-ycc3csyh	254	21	model	model	NN
cord-270892-ycc3csyh	254	22	of	of	IN
cord-270892-ycc3csyh	254	23	rhinovirus	rhinovirus	JJ
cord-270892-ycc3csyh	254	24	infection	infection	NN
cord-270892-ycc3csyh	254	25	in	in	IN
cord-270892-ycc3csyh	254	26	which	which	WDT
cord-270892-ycc3csyh	254	27	growth	growth	NN
cord-270892-ycc3csyh	254	28	could	could	MD
cord-270892-ycc3csyh	254	29	be	be	VB
cord-270892-ycc3csyh	254	30	demonstrated	demonstrate	VBN
cord-270892-ycc3csyh	254	31	.	.	.
cord-270892-ycc3csyh	255	1	146	146	CD
cord-270892-ycc3csyh	256	1	Based	base	VBN
cord-270892-ycc3csyh	256	2	on	on	IN
cord-270892-ycc3csyh	256	3	the	the	DT
cord-270892-ycc3csyh	256	4	fact	fact	NN
cord-270892-ycc3csyh	256	5	that	that	IN
cord-270892-ycc3csyh	256	6	the	the	DT
cord-270892-ycc3csyh	256	7	LDL	LDL	NNP
cord-270892-ycc3csyh	256	8	receptor	receptor	NN
cord-270892-ycc3csyh	256	9	family	family	NN
cord-270892-ycc3csyh	256	10	is	be	VBZ
cord-270892-ycc3csyh	256	11	highly	highly	RB
cord-270892-ycc3csyh	256	12	conserved	conserve	VBN
cord-270892-ycc3csyh	256	13	between	between	IN
cord-270892-ycc3csyh	256	14	human	human	NN
cord-270892-ycc3csyh	256	15	and	and	CC
cord-270892-ycc3csyh	256	16	mouse	mouse	NN
cord-270892-ycc3csyh	256	17	,	,	,
cord-270892-ycc3csyh	256	18	Newcomb	Newcomb	NNP
cord-270892-ycc3csyh	256	19	et	et	NNP
cord-270892-ycc3csyh	256	20	al	al	NNP
cord-270892-ycc3csyh	256	21	.	.	NNP
cord-270892-ycc3csyh	256	22	examined	examine	VBD
cord-270892-ycc3csyh	256	23	whether	whether	IN
cord-270892-ycc3csyh	256	24	HRV-1B	HRV-1B	NNP
cord-270892-ycc3csyh	256	25	,	,	,
cord-270892-ycc3csyh	256	26	another	another	DT
cord-270892-ycc3csyh	256	27	minor	minor	JJ
cord-270892-ycc3csyh	256	28	group	group	NN
cord-270892-ycc3csyh	256	29	virus	virus	NN
cord-270892-ycc3csyh	256	30	,	,	,
cord-270892-ycc3csyh	256	31	may	may	MD
cord-270892-ycc3csyh	256	32	infect	infect	VB
cord-270892-ycc3csyh	256	33	mouse	mouse	NN
cord-270892-ycc3csyh	256	34	airways	airway	NNS
cord-270892-ycc3csyh	256	35	in	in	IN
cord-270892-ycc3csyh	256	36	6-to	6-to	CD
cord-270892-ycc3csyh	256	37	8-week	8-week	CD
cord-270892-ycc3csyh	256	38	-	-	HYPH
cord-270892-ycc3csyh	256	39	old	old	JJ
cord-270892-ycc3csyh	256	40	female	female	NN
cord-270892-ycc3csyh	256	41	C57BL/6	C57BL/6	NNP
cord-270892-ycc3csyh	256	42	mice	mouse	NNS
cord-270892-ycc3csyh	256	43	.	.	.
cord-270892-ycc3csyh	257	1	147	147	CD
cord-270892-ycc3csyh	258	1	The	the	DT
cord-270892-ycc3csyh	258	2	authors	author	NNS
cord-270892-ycc3csyh	258	3	demonstrated	demonstrate	VBD
cord-270892-ycc3csyh	258	4	that	that	IN
cord-270892-ycc3csyh	258	5	this	this	DT
cord-270892-ycc3csyh	258	6	HRV	HRV	NNP
cord-270892-ycc3csyh	258	7	serotype	serotype	NN
cord-270892-ycc3csyh	258	8	replicates	replicate	VBZ
cord-270892-ycc3csyh	258	9	and	and	CC
cord-270892-ycc3csyh	258	10	induces	induce	VBZ
cord-270892-ycc3csyh	258	11	airway	airway	JJ
cord-270892-ycc3csyh	258	12	inflammation	inflammation	NN
cord-270892-ycc3csyh	258	13	in	in	IN
cord-270892-ycc3csyh	258	14	vivo	vivo	NNP
cord-270892-ycc3csyh	258	15	.	.	.
cord-270892-ycc3csyh	259	1	These	these	DT
cord-270892-ycc3csyh	259	2	results	result	NNS
cord-270892-ycc3csyh	259	3	strongly	strongly	RB
cord-270892-ycc3csyh	259	4	correspond	correspond	VBP
cord-270892-ycc3csyh	259	5	to	to	IN
cord-270892-ycc3csyh	259	6	those	those	DT
cord-270892-ycc3csyh	259	7	of	of	IN
cord-270892-ycc3csyh	259	8	Bartlett	Bartlett	NNP
cord-270892-ycc3csyh	259	9	et	et	NNP
cord-270892-ycc3csyh	259	10	al	al	NNP
cord-270892-ycc3csyh	259	11	.	.	.
cord-270892-ycc3csyh	260	1	who	who	WP
cord-270892-ycc3csyh	260	2	established	establish	VBD
cord-270892-ycc3csyh	260	3	three	three	CD
cord-270892-ycc3csyh	260	4	novel	novel	JJ
cord-270892-ycc3csyh	260	5	mouse	mouse	NN
cord-270892-ycc3csyh	260	6	models	model	NNS
cord-270892-ycc3csyh	260	7	of	of	IN
cord-270892-ycc3csyh	260	8	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	260	9	infection	infection	NN
cord-270892-ycc3csyh	260	10	in	in	IN
cord-270892-ycc3csyh	260	11	BALB7c	balb7c	JJ
cord-270892-ycc3csyh	260	12	mice	mouse	NNS
cord-270892-ycc3csyh	260	13	.	.	.
cord-270892-ycc3csyh	261	1	148	148	CD
cord-270892-ycc3csyh	262	1	In	in	IN
cord-270892-ycc3csyh	262	2	the	the	DT
cord-270892-ycc3csyh	262	3	first	first	JJ
cord-270892-ycc3csyh	262	4	model	model	NN
cord-270892-ycc3csyh	262	5	,	,	,
cord-270892-ycc3csyh	262	6	6-week	6-week	JJ
cord-270892-ycc3csyh	262	7	-	-	HYPH
cord-270892-ycc3csyh	262	8	old	old	JJ
cord-270892-ycc3csyh	262	9	BALB	BALB	NNP
cord-270892-ycc3csyh	262	10	/	/	SYM
cord-270892-ycc3csyh	262	11	c	c	NN
cord-270892-ycc3csyh	262	12	mice	mouse	NNS
cord-270892-ycc3csyh	262	13	were	be	VBD
cord-270892-ycc3csyh	262	14	infected	infect	VBN
cord-270892-ycc3csyh	262	15	with	with	IN
cord-270892-ycc3csyh	262	16	HRV-1B.	HRV-1B.	NNS
cord-270892-ycc3csyh	263	1	In	in	IN
cord-270892-ycc3csyh	263	2	the	the	DT
cord-270892-ycc3csyh	263	3	second	second	JJ
cord-270892-ycc3csyh	263	4	model	model	NN
cord-270892-ycc3csyh	263	5	,	,	,
cord-270892-ycc3csyh	263	6	transgenic	transgenic	JJ
cord-270892-ycc3csyh	263	7	BALB	BALB	NNP
cord-270892-ycc3csyh	263	8	/	/	SYM
cord-270892-ycc3csyh	263	9	c	c	NN
cord-270892-ycc3csyh	263	10	mice	mouse	NNS
cord-270892-ycc3csyh	263	11	,	,	,
cord-270892-ycc3csyh	263	12	expressing	express	VBG
cord-270892-ycc3csyh	263	13	a	a	DT
cord-270892-ycc3csyh	263	14	mouse	mouse	NN
cord-270892-ycc3csyh	263	15	-	-	HYPH
cord-270892-ycc3csyh	263	16	human	human	JJ
cord-270892-ycc3csyh	263	17	ICAM-1	icam-1	NN
cord-270892-ycc3csyh	263	18	chimera	chimera	NN
cord-270892-ycc3csyh	263	19	,	,	,
cord-270892-ycc3csyh	263	20	were	be	VBD
cord-270892-ycc3csyh	263	21	inoculated	inoculate	VBN
cord-270892-ycc3csyh	263	22	with	with	IN
cord-270892-ycc3csyh	263	23	the	the	DT
cord-270892-ycc3csyh	263	24	major	major	JJ
cord-270892-ycc3csyh	263	25	group	group	NN
cord-270892-ycc3csyh	263	26	HRV-16	HRV-16	NNP
cord-270892-ycc3csyh	263	27	.	.	.
cord-270892-ycc3csyh	264	1	Rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	264	2	-	-	HYPH
cord-270892-ycc3csyh	264	3	induced	induce	VBN
cord-270892-ycc3csyh	264	4	exacerbation	exacerbation	NN
cord-270892-ycc3csyh	264	5	of	of	IN
cord-270892-ycc3csyh	264	6	allergic	allergic	JJ
cord-270892-ycc3csyh	264	7	airway	airway	NN
cord-270892-ycc3csyh	264	8	inflammation	inflammation	NN
cord-270892-ycc3csyh	264	9	is	be	VBZ
cord-270892-ycc3csyh	264	10	mimicked	mimic	VBN
cord-270892-ycc3csyh	264	11	in	in	IN
cord-270892-ycc3csyh	264	12	the	the	DT
cord-270892-ycc3csyh	264	13	third	third	JJ
cord-270892-ycc3csyh	264	14	model	model	NN
cord-270892-ycc3csyh	264	15	.	.	.
cord-270892-ycc3csyh	265	1	Due	due	IN
cord-270892-ycc3csyh	265	2	to	to	IN
cord-270892-ycc3csyh	265	3	the	the	DT
cord-270892-ycc3csyh	265	4	lack	lack	NN
cord-270892-ycc3csyh	265	5	of	of	IN
cord-270892-ycc3csyh	265	6	a	a	DT
cord-270892-ycc3csyh	265	7	small	small	JJ
cord-270892-ycc3csyh	265	8	-	-	HYPH
cord-270892-ycc3csyh	265	9	animal	animal	NN
cord-270892-ycc3csyh	265	10	model	model	NN
cord-270892-ycc3csyh	265	11	for	for	IN
cord-270892-ycc3csyh	265	12	HRV	HRV	NNP
cord-270892-ycc3csyh	265	13	infection	infection	NN
cord-270892-ycc3csyh	265	14	until	until	IN
cord-270892-ycc3csyh	265	15	2008	2008	CD
cord-270892-ycc3csyh	265	16	,	,	,
cord-270892-ycc3csyh	265	17	the	the	DT
cord-270892-ycc3csyh	265	18	experimental	experimental	JJ
cord-270892-ycc3csyh	265	19	human	human	JJ
cord-270892-ycc3csyh	265	20	challenge	challenge	NN
cord-270892-ycc3csyh	265	21	model	model	NN
cord-270892-ycc3csyh	265	22	has	have	VBZ
cord-270892-ycc3csyh	265	23	to	to	TO
cord-270892-ycc3csyh	265	24	be	be	VB
cord-270892-ycc3csyh	265	25	used	use	VBN
cord-270892-ycc3csyh	265	26	to	to	TO
cord-270892-ycc3csyh	265	27	approve	approve	VB
cord-270892-ycc3csyh	265	28	effects	effect	NNS
cord-270892-ycc3csyh	265	29	of	of	IN
cord-270892-ycc3csyh	265	30	potential	potential	JJ
cord-270892-ycc3csyh	265	31	antiviral	antiviral	JJ
cord-270892-ycc3csyh	265	32	drugs	drug	NNS
cord-270892-ycc3csyh	265	33	under	under	IN
cord-270892-ycc3csyh	265	34	controlled	control	VBN
cord-270892-ycc3csyh	265	35	conditions	condition	NNS
cord-270892-ycc3csyh	265	36	in	in	IN
cord-270892-ycc3csyh	265	37	preclinical	preclinical	JJ
cord-270892-ycc3csyh	265	38	studies	study	NNS
cord-270892-ycc3csyh	265	39	.	.	.
cord-270892-ycc3csyh	266	1	Volunteers	volunteer	NNS
cord-270892-ycc3csyh	266	2	were	be	VBD
cord-270892-ycc3csyh	266	3	experimentally	experimentally	RB
cord-270892-ycc3csyh	266	4	inoculated	inoculate	VBN
cord-270892-ycc3csyh	266	5	with	with	IN
cord-270892-ycc3csyh	266	6	various	various	JJ
cord-270892-ycc3csyh	266	7	serotypes	serotype	NNS
cord-270892-ycc3csyh	266	8	e.g.	e.g.	IN
cord-270892-ycc3csyh	266	9	HRV-4	HRV-4	NNP
cord-270892-ycc3csyh	266	10	,	,	,
cord-270892-ycc3csyh	266	11	HRV-9	HRV-9	NNP
cord-270892-ycc3csyh	266	12	,	,	,
cord-270892-ycc3csyh	266	13	HRV23	HRV23	NNP
cord-270892-ycc3csyh	266	14	,	,	,
cord-270892-ycc3csyh	266	15	HRV-29	hrv-29	CD
cord-270892-ycc3csyh	266	16	,	,	,
cord-270892-ycc3csyh	266	17	and	and	CC
cord-270892-ycc3csyh	266	18	HRV-39	HRV-39	NNP
cord-270892-ycc3csyh	266	19	to	to	TO
cord-270892-ycc3csyh	266	20	examine	examine	VB
cord-270892-ycc3csyh	266	21	the	the	DT
cord-270892-ycc3csyh	266	22	efficacy	efficacy	NN
cord-270892-ycc3csyh	266	23	of	of	IN
cord-270892-ycc3csyh	266	24	potential	potential	JJ
cord-270892-ycc3csyh	266	25	antiviral	antiviral	JJ
cord-270892-ycc3csyh	266	26	drugs	drug	NNS
cord-270892-ycc3csyh	266	27	under	under	IN
cord-270892-ycc3csyh	266	28	standardized	standardized	JJ
cord-270892-ycc3csyh	266	29	conditions	condition	NNS
cord-270892-ycc3csyh	266	30	.	.	.
cord-270892-ycc3csyh	267	1	[	[	-LRB-
cord-270892-ycc3csyh	267	2	149	149	CD
cord-270892-ycc3csyh	267	3	]	]	-RRB-
cord-270892-ycc3csyh	267	4	[	[	-LRB-
cord-270892-ycc3csyh	267	5	150	150	CD
cord-270892-ycc3csyh	267	6	]	]	-RRB-
cord-270892-ycc3csyh	267	7	[	[	-LRB-
cord-270892-ycc3csyh	267	8	151	151	CD
cord-270892-ycc3csyh	267	9	]	]	-RRB-
cord-270892-ycc3csyh	267	10	[	[	-LRB-
cord-270892-ycc3csyh	267	11	152	152	CD
cord-270892-ycc3csyh	267	12	]	]	-RRB-
cord-270892-ycc3csyh	267	13	[	[	-LRB-
cord-270892-ycc3csyh	267	14	153	153	CD
cord-270892-ycc3csyh	267	15	]	]	-RRB-
cord-270892-ycc3csyh	267	16	[	[	-LRB-
cord-270892-ycc3csyh	267	17	154	154	CD
cord-270892-ycc3csyh	267	18	]	]	-RRB-
cord-270892-ycc3csyh	268	1	Examples	example	NNS
cord-270892-ycc3csyh	268	2	and	and	CC
cord-270892-ycc3csyh	268	3	results	result	NNS
cord-270892-ycc3csyh	268	4	of	of	IN
cord-270892-ycc3csyh	268	5	these	these	DT
cord-270892-ycc3csyh	268	6	studies	study	NNS
cord-270892-ycc3csyh	268	7	with	with	IN
cord-270892-ycc3csyh	268	8	capsid	capsid	NN
cord-270892-ycc3csyh	268	9	-	-	HYPH
cord-270892-ycc3csyh	268	10	binders	binder	NNS
cord-270892-ycc3csyh	268	11	,	,	,
cord-270892-ycc3csyh	268	12	protease	protease	NN
cord-270892-ycc3csyh	268	13	,	,	,
cord-270892-ycc3csyh	268	14	and	and	CC
cord-270892-ycc3csyh	268	15	RNA	RNA	NNP
cord-270892-ycc3csyh	268	16	synthesis	synthesis	NN
cord-270892-ycc3csyh	268	17	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	268	18	,	,	,
cord-270892-ycc3csyh	268	19	as	as	RB
cord-270892-ycc3csyh	268	20	well	well	RB
cord-270892-ycc3csyh	268	21	as	as	IN
cord-270892-ycc3csyh	268	22	interferons	interferon	NNS
cord-270892-ycc3csyh	268	23	are	be	VBP
cord-270892-ycc3csyh	268	24	described	describe	VBN
cord-270892-ycc3csyh	268	25	in	in	IN
cord-270892-ycc3csyh	268	26	the	the	DT
cord-270892-ycc3csyh	268	27	following	follow	VBG
cord-270892-ycc3csyh	268	28	sections	section	NNS
cord-270892-ycc3csyh	268	29	.	.	.
cord-270892-ycc3csyh	269	1	Antiviral	antiviral	JJ
cord-270892-ycc3csyh	269	2	agents	agent	NNS
cord-270892-ycc3csyh	269	3	that	that	WDT
cord-270892-ycc3csyh	269	4	inhibit	inhibit	VBP
cord-270892-ycc3csyh	269	5	virus	virus	NN
cord-270892-ycc3csyh	269	6	attachment	attachment	NN
cord-270892-ycc3csyh	269	7	,	,	,
cord-270892-ycc3csyh	269	8	capsid	capsid	NN
cord-270892-ycc3csyh	269	9	uncoating	uncoating	NN
cord-270892-ycc3csyh	269	10	,	,	,
cord-270892-ycc3csyh	269	11	protein	protein	NN
cord-270892-ycc3csyh	269	12	and	and	CC
cord-270892-ycc3csyh	269	13	RNA	RNA	NNP
cord-270892-ycc3csyh	269	14	synthesis	synthesis	NN
cord-270892-ycc3csyh	269	15	of	of	IN
cord-270892-ycc3csyh	269	16	picornaviruses	picornavirus	NNS
cord-270892-ycc3csyh	269	17	are	be	VBP
cord-270892-ycc3csyh	269	18	the	the	DT
cord-270892-ycc3csyh	269	19	best	well	RBS
cord-270892-ycc3csyh	269	20	studied	study	VBN
cord-270892-ycc3csyh	269	21	,	,	,
cord-270892-ycc3csyh	269	22	95	95	CD
cord-270892-ycc3csyh	269	23	,	,	,
cord-270892-ycc3csyh	269	24	[	[	-LRB-
cord-270892-ycc3csyh	269	25	155	155	CD
cord-270892-ycc3csyh	269	26	]	]	-RRB-
cord-270892-ycc3csyh	269	27	[	[	-LRB-
cord-270892-ycc3csyh	269	28	156	156	CD
cord-270892-ycc3csyh	269	29	]	]	-RRB-
cord-270892-ycc3csyh	269	30	[	[	-LRB-
cord-270892-ycc3csyh	269	31	157	157	CD
cord-270892-ycc3csyh	269	32	]	]	-RRB-
cord-270892-ycc3csyh	269	33	and	and	CC
cord-270892-ycc3csyh	269	34	will	will	MD
cord-270892-ycc3csyh	269	35	be	be	VB
cord-270892-ycc3csyh	269	36	in	in	IN
cord-270892-ycc3csyh	269	37	the	the	DT
cord-270892-ycc3csyh	269	38	focus	focus	NN
cord-270892-ycc3csyh	269	39	of	of	IN
cord-270892-ycc3csyh	269	40	this	this	DT
cord-270892-ycc3csyh	269	41	section	section	NN
cord-270892-ycc3csyh	269	42	.	.	.
cord-270892-ycc3csyh	270	1	Inhibition	inhibition	NN
cord-270892-ycc3csyh	270	2	of	of	IN
cord-270892-ycc3csyh	270	3	virus	virus	NN
cord-270892-ycc3csyh	270	4	attachment	attachment	NN
cord-270892-ycc3csyh	270	5	and/or	and/or	CC
cord-270892-ycc3csyh	270	6	uncoating	uncoating	NN
cord-270892-ycc3csyh	270	7	interrupts	interrupt	VBZ
cord-270892-ycc3csyh	270	8	the	the	DT
cord-270892-ycc3csyh	270	9	viral	viral	JJ
cord-270892-ycc3csyh	270	10	life	life	NN
cord-270892-ycc3csyh	270	11	cycle	cycle	NN
cord-270892-ycc3csyh	270	12	at	at	IN
cord-270892-ycc3csyh	270	13	its	-PRON-	PRP$
cord-270892-ycc3csyh	270	14	beginning	beginning	NN
cord-270892-ycc3csyh	270	15	and	and	CC
cord-270892-ycc3csyh	270	16	prevents	prevent	VBZ
cord-270892-ycc3csyh	270	17	HRV	HRV	NNP
cord-270892-ycc3csyh	270	18	infection	infection	NN
cord-270892-ycc3csyh	270	19	.	.	.
cord-270892-ycc3csyh	271	1	Options	option	NNS
cord-270892-ycc3csyh	271	2	to	to	TO
cord-270892-ycc3csyh	271	3	prevent	prevent	VB
cord-270892-ycc3csyh	271	4	these	these	DT
cord-270892-ycc3csyh	271	5	early	early	JJ
cord-270892-ycc3csyh	271	6	steps	step	NNS
cord-270892-ycc3csyh	271	7	of	of	IN
cord-270892-ycc3csyh	271	8	the	the	DT
cord-270892-ycc3csyh	271	9	viral	viral	JJ
cord-270892-ycc3csyh	271	10	life	life	NN
cord-270892-ycc3csyh	271	11	cycle	cycle	NN
cord-270892-ycc3csyh	271	12	include	include	VBP
cord-270892-ycc3csyh	271	13	(	(	-LRB-
cord-270892-ycc3csyh	271	14	i	i	NN
cord-270892-ycc3csyh	271	15	)	)	-RRB-
cord-270892-ycc3csyh	271	16	virus	virus	NN
cord-270892-ycc3csyh	271	17	neutralization	neutralization	NN
cord-270892-ycc3csyh	271	18	by	by	IN
cord-270892-ycc3csyh	271	19	HRV	HRV	NNP
cord-270892-ycc3csyh	271	20	-	-	HYPH
cord-270892-ycc3csyh	271	21	specific	specific	JJ
cord-270892-ycc3csyh	271	22	antibodies	antibody	NNS
cord-270892-ycc3csyh	271	23	,	,	,
cord-270892-ycc3csyh	271	24	(	(	-LRB-
cord-270892-ycc3csyh	271	25	ii	ii	NN
cord-270892-ycc3csyh	271	26	)	)	-RRB-
cord-270892-ycc3csyh	271	27	receptor	receptor	NN
cord-270892-ycc3csyh	271	28	blockade	blockade	NN
cord-270892-ycc3csyh	271	29	by	by	IN
cord-270892-ycc3csyh	271	30	antibodies	antibody	NNS
cord-270892-ycc3csyh	271	31	directed	direct	VBN
cord-270892-ycc3csyh	271	32	against	against	IN
cord-270892-ycc3csyh	271	33	the	the	DT
cord-270892-ycc3csyh	271	34	cellular	cellular	JJ
cord-270892-ycc3csyh	271	35	receptors	receptor	NNS
cord-270892-ycc3csyh	271	36	ICAM-1	icam-1	RB
cord-270892-ycc3csyh	271	37	or	or	CC
cord-270892-ycc3csyh	271	38	LDL	LDL	NNP
cord-270892-ycc3csyh	271	39	,	,	,
cord-270892-ycc3csyh	271	40	(	(	-LRB-
cord-270892-ycc3csyh	271	41	iii	iii	NN
cord-270892-ycc3csyh	271	42	)	)	-RRB-
cord-270892-ycc3csyh	271	43	by	by	IN
cord-270892-ycc3csyh	271	44	soluble	soluble	JJ
cord-270892-ycc3csyh	271	45	receptor	receptor	NN
cord-270892-ycc3csyh	271	46	molecules	molecule	NNS
cord-270892-ycc3csyh	271	47	,	,	,
cord-270892-ycc3csyh	271	48	or	or	CC
cord-270892-ycc3csyh	271	49	(	(	-LRB-
cord-270892-ycc3csyh	271	50	iv	iv	LS
cord-270892-ycc3csyh	271	51	)	)	-RRB-
cord-270892-ycc3csyh	271	52	by	by	IN
cord-270892-ycc3csyh	271	53	compounds	compound	NNS
cord-270892-ycc3csyh	271	54	interacting	interact	VBG
cord-270892-ycc3csyh	271	55	with	with	IN
cord-270892-ycc3csyh	271	56	the	the	DT
cord-270892-ycc3csyh	271	57	viral	viral	JJ
cord-270892-ycc3csyh	271	58	capsid	capsid	NN
cord-270892-ycc3csyh	271	59	.	.	.
cord-270892-ycc3csyh	272	1	Because	because	IN
cord-270892-ycc3csyh	272	2	of	of	IN
cord-270892-ycc3csyh	272	3	the	the	DT
cord-270892-ycc3csyh	272	4	high	high	JJ
cord-270892-ycc3csyh	272	5	number	number	NN
cord-270892-ycc3csyh	272	6	of	of	IN
cord-270892-ycc3csyh	272	7	serotypes	serotype	NNS
cord-270892-ycc3csyh	272	8	circulating	circulate	VBG
cord-270892-ycc3csyh	272	9	often	often	RB
cord-270892-ycc3csyh	272	10	in	in	IN
cord-270892-ycc3csyh	272	11	parallel	parallel	NN
cord-270892-ycc3csyh	272	12	,	,	,
cord-270892-ycc3csyh	272	13	application	application	NN
cord-270892-ycc3csyh	272	14	of	of	IN
cord-270892-ycc3csyh	272	15	HRV	HRV	NNP
cord-270892-ycc3csyh	272	16	-	-	HYPH
cord-270892-ycc3csyh	272	17	specific	specific	JJ
cord-270892-ycc3csyh	272	18	antibodies	antibody	NNS
cord-270892-ycc3csyh	272	19	is	be	VBZ
cord-270892-ycc3csyh	272	20	thought	think	VBN
cord-270892-ycc3csyh	272	21	to	to	TO
cord-270892-ycc3csyh	272	22	be	be	VB
cord-270892-ycc3csyh	272	23	no	no	DT
cord-270892-ycc3csyh	272	24	promising	promising	JJ
cord-270892-ycc3csyh	272	25	approach	approach	NN
cord-270892-ycc3csyh	272	26	for	for	IN
cord-270892-ycc3csyh	272	27	prevention	prevention	NN
cord-270892-ycc3csyh	272	28	or	or	CC
cord-270892-ycc3csyh	272	29	therapy	therapy	NN
cord-270892-ycc3csyh	272	30	of	of	IN
cord-270892-ycc3csyh	272	31	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	272	32	infection	infection	NN
cord-270892-ycc3csyh	272	33	.	.	.
cord-270892-ycc3csyh	273	1	In	in	IN
cord-270892-ycc3csyh	273	2	contrast	contrast	NN
cord-270892-ycc3csyh	273	3	,	,	,
cord-270892-ycc3csyh	273	4	antibodies	antibody	NNS
cord-270892-ycc3csyh	273	5	directed	direct	VBN
cord-270892-ycc3csyh	273	6	against	against	IN
cord-270892-ycc3csyh	273	7	the	the	DT
cord-270892-ycc3csyh	273	8	cellular	cellular	JJ
cord-270892-ycc3csyh	273	9	receptor	receptor	NN
cord-270892-ycc3csyh	273	10	or	or	CC
cord-270892-ycc3csyh	273	11	soluble	soluble	JJ
cord-270892-ycc3csyh	273	12	receptor	receptor	NN
cord-270892-ycc3csyh	273	13	molecules	molecule	NNS
cord-270892-ycc3csyh	273	14	of	of	IN
cord-270892-ycc3csyh	273	15	major	major	JJ
cord-270892-ycc3csyh	273	16	or	or	CC
cord-270892-ycc3csyh	273	17	minor	minor	JJ
cord-270892-ycc3csyh	273	18	group	group	NN
cord-270892-ycc3csyh	273	19	HRV	HRV	NNP
cord-270892-ycc3csyh	273	20	could	could	MD
cord-270892-ycc3csyh	273	21	inhibit	inhibit	VB
cord-270892-ycc3csyh	273	22	90	90	CD
cord-270892-ycc3csyh	273	23	and	and	CC
cord-270892-ycc3csyh	273	24	10	10	CD
cord-270892-ycc3csyh	273	25	%	%	NN
cord-270892-ycc3csyh	273	26	of	of	IN
cord-270892-ycc3csyh	273	27	HRV	HRV	NNP
cord-270892-ycc3csyh	273	28	serotypes	serotype	NNS
cord-270892-ycc3csyh	273	29	,	,	,
cord-270892-ycc3csyh	273	30	respectively	respectively	RB
cord-270892-ycc3csyh	273	31	.	.	.
cord-270892-ycc3csyh	274	1	Therefore	therefore	RB
cord-270892-ycc3csyh	274	2	,	,	,
cord-270892-ycc3csyh	274	3	the	the	DT
cord-270892-ycc3csyh	274	4	strategy	strategy	NN
cord-270892-ycc3csyh	274	5	to	to	TO
cord-270892-ycc3csyh	274	6	prevent	prevent	VB
cord-270892-ycc3csyh	274	7	virus	virus	NN
cord-270892-ycc3csyh	274	8	-	-	HYPH
cord-270892-ycc3csyh	274	9	receptor	receptor	NN
cord-270892-ycc3csyh	274	10	interaction	interaction	NN
cord-270892-ycc3csyh	274	11	by	by	IN
cord-270892-ycc3csyh	274	12	receptor	receptor	NN
cord-270892-ycc3csyh	274	13	antibodies	antibody	NNS
cord-270892-ycc3csyh	274	14	or	or	CC
cord-270892-ycc3csyh	274	15	soluble	soluble	JJ
cord-270892-ycc3csyh	274	16	receptor	receptor	NN
cord-270892-ycc3csyh	274	17	molecules	molecule	NNS
cord-270892-ycc3csyh	274	18	has	have	VBZ
cord-270892-ycc3csyh	274	19	been	be	VBN
cord-270892-ycc3csyh	274	20	extensively	extensively	RB
cord-270892-ycc3csyh	274	21	evaluated	evaluate	VBN
cord-270892-ycc3csyh	274	22	in	in	IN
cord-270892-ycc3csyh	274	23	vitro	vitro	FW
cord-270892-ycc3csyh	274	24	as	as	RB
cord-270892-ycc3csyh	274	25	well	well	RB
cord-270892-ycc3csyh	274	26	as	as	IN
cord-270892-ycc3csyh	274	27	in	in	IN
cord-270892-ycc3csyh	274	28	vivo	vivo	NNP
cord-270892-ycc3csyh	274	29	.	.	.
cord-270892-ycc3csyh	275	1	The	the	DT
cord-270892-ycc3csyh	275	2	antiviral	antiviral	JJ
cord-270892-ycc3csyh	275	3	activity	activity	NN
cord-270892-ycc3csyh	275	4	of	of	IN
cord-270892-ycc3csyh	275	5	ICAM	ICAM	NNP
cord-270892-ycc3csyh	275	6	-	-	HYPH
cord-270892-ycc3csyh	275	7	and	and	CC
cord-270892-ycc3csyh	275	8	LDL	ldl	NN
cord-270892-ycc3csyh	275	9	-	-	HYPH
cord-270892-ycc3csyh	275	10	specific	specific	JJ
cord-270892-ycc3csyh	275	11	antibodies	antibody	NNS
cord-270892-ycc3csyh	275	12	was	be	VBD
cord-270892-ycc3csyh	275	13	confirmed	confirm	VBN
cord-270892-ycc3csyh	275	14	in	in	IN
cord-270892-ycc3csyh	275	15	cell	cell	NN
cord-270892-ycc3csyh	275	16	culture	culture	NN
cord-270892-ycc3csyh	275	17	.	.	.
cord-270892-ycc3csyh	276	1	158	158	CD
cord-270892-ycc3csyh	276	2	,	,	,
cord-270892-ycc3csyh	276	3	159	159	CD
cord-270892-ycc3csyh	277	1	Furthermore	furthermore	RB
cord-270892-ycc3csyh	277	2	,	,	,
cord-270892-ycc3csyh	277	3	the	the	DT
cord-270892-ycc3csyh	277	4	prophylactic	prophylactic	JJ
cord-270892-ycc3csyh	277	5	effectiveness	effectiveness	NN
cord-270892-ycc3csyh	277	6	and	and	CC
cord-270892-ycc3csyh	277	7	safety	safety	NN
cord-270892-ycc3csyh	277	8	of	of	IN
cord-270892-ycc3csyh	277	9	intranasally	intranasally	RB
cord-270892-ycc3csyh	277	10	administered	administer	VBN
cord-270892-ycc3csyh	277	11	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	277	12	murine	murine	JJ
cord-270892-ycc3csyh	277	13	ICAM-1	ICAM-1	NNP
cord-270892-ycc3csyh	277	14	antibody	antibody	NN
cord-270892-ycc3csyh	277	15	was	be	VBD
cord-270892-ycc3csyh	277	16	assessed	assess	VBN
cord-270892-ycc3csyh	277	17	in	in	IN
cord-270892-ycc3csyh	277	18	two	two	CD
cord-270892-ycc3csyh	277	19	double	double	JJ
cord-270892-ycc3csyh	277	20	-	-	HYPH
cord-270892-ycc3csyh	277	21	blind	blind	JJ
cord-270892-ycc3csyh	277	22	,	,	,
cord-270892-ycc3csyh	277	23	placebo	placebo	NN
cord-270892-ycc3csyh	277	24	-	-	HYPH
cord-270892-ycc3csyh	277	25	controlled	control	VBN
cord-270892-ycc3csyh	277	26	,	,	,
cord-270892-ycc3csyh	277	27	randomized	randomized	JJ
cord-270892-ycc3csyh	277	28	studies	study	NNS
cord-270892-ycc3csyh	277	29	of	of	IN
cord-270892-ycc3csyh	277	30	volunteers	volunteer	NNS
cord-270892-ycc3csyh	277	31	experimentally	experimentally	RB
cord-270892-ycc3csyh	277	32	inoculated	inoculate	VBD
cord-270892-ycc3csyh	277	33	with	with	IN
cord-270892-ycc3csyh	277	34	HRV-39	HRV-39	NNP
cord-270892-ycc3csyh	277	35	.	.	.
cord-270892-ycc3csyh	277	36	160	160	CD
cord-270892-ycc3csyh	278	1	In	in	IN
cord-270892-ycc3csyh	278	2	the	the	DT
cord-270892-ycc3csyh	278	3	result	result	NN
cord-270892-ycc3csyh	278	4	,	,	,
cord-270892-ycc3csyh	278	5	no	no	DT
cord-270892-ycc3csyh	278	6	toxicity	toxicity	NN
cord-270892-ycc3csyh	278	7	related	relate	VBN
cord-270892-ycc3csyh	278	8	to	to	IN
cord-270892-ycc3csyh	278	9	antibody	antibody	NN
cord-270892-ycc3csyh	278	10	application	application	NN
cord-270892-ycc3csyh	278	11	was	be	VBD
cord-270892-ycc3csyh	278	12	recognized	recognize	VBN
cord-270892-ycc3csyh	278	13	.	.	.
cord-270892-ycc3csyh	279	1	The	the	DT
cord-270892-ycc3csyh	279	2	higher	high	JJR
cord-270892-ycc3csyh	279	3	dosage	dosage	NN
cord-270892-ycc3csyh	279	4	of	of	IN
cord-270892-ycc3csyh	279	5	1	1	CD
cord-270892-ycc3csyh	279	6	mg	mg	NNP
cord-270892-ycc3csyh	279	7	/	/	SYM
cord-270892-ycc3csyh	279	8	subject	subject	NN
cord-270892-ycc3csyh	279	9	of	of	IN
cord-270892-ycc3csyh	279	10	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	279	11	murine	murine	JJ
cord-270892-ycc3csyh	279	12	receptor	receptor	NN
cord-270892-ycc3csyh	279	13	antibody	antibody	NN
cord-270892-ycc3csyh	279	14	did	do	VBD
cord-270892-ycc3csyh	279	15	not	not	RB
cord-270892-ycc3csyh	279	16	reduce	reduce	VB
cord-270892-ycc3csyh	279	17	overall	overall	JJ
cord-270892-ycc3csyh	279	18	infection	infection	NN
cord-270892-ycc3csyh	279	19	or	or	CC
cord-270892-ycc3csyh	279	20	illness	illness	NN
cord-270892-ycc3csyh	279	21	rates	rate	NNS
cord-270892-ycc3csyh	279	22	,	,	,
cord-270892-ycc3csyh	279	23	but	but	CC
cord-270892-ycc3csyh	279	24	was	be	VBD
cord-270892-ycc3csyh	279	25	associated	associate	VBN
cord-270892-ycc3csyh	279	26	with	with	IN
cord-270892-ycc3csyh	279	27	a	a	DT
cord-270892-ycc3csyh	279	28	1	1	CD
cord-270892-ycc3csyh	279	29	-	-	SYM
cord-270892-ycc3csyh	279	30	2	2	CD
cord-270892-ycc3csyh	279	31	day	day	NN
cord-270892-ycc3csyh	279	32	delay	delay	NN
cord-270892-ycc3csyh	279	33	in	in	IN
cord-270892-ycc3csyh	279	34	the	the	DT
cord-270892-ycc3csyh	279	35	onset	onset	NN
cord-270892-ycc3csyh	279	36	of	of	IN
cord-270892-ycc3csyh	279	37	virus	virus	NN
cord-270892-ycc3csyh	279	38	shedding	shed	VBG
cord-270892-ycc3csyh	279	39	and	and	CC
cord-270892-ycc3csyh	279	40	cold	cold	JJ
cord-270892-ycc3csyh	279	41	symptoms	symptom	NNS
cord-270892-ycc3csyh	279	42	.	.	.
cord-270892-ycc3csyh	280	1	Viral	viral	JJ
cord-270892-ycc3csyh	280	2	titers	titer	NNS
cord-270892-ycc3csyh	280	3	and	and	CC
cord-270892-ycc3csyh	280	4	nasal	nasal	NN
cord-270892-ycc3csyh	280	5	symptoms	symptom	NNS
cord-270892-ycc3csyh	280	6	were	be	VBD
cord-270892-ycc3csyh	280	7	significantly	significantly	RB
cord-270892-ycc3csyh	280	8	reduced	reduce	VBN
cord-270892-ycc3csyh	280	9	on	on	IN
cord-270892-ycc3csyh	280	10	the	the	DT
cord-270892-ycc3csyh	280	11	second	second	JJ
cord-270892-ycc3csyh	280	12	day	day	NN
cord-270892-ycc3csyh	280	13	after	after	IN
cord-270892-ycc3csyh	280	14	challenge	challenge	NN
cord-270892-ycc3csyh	280	15	.	.	.
cord-270892-ycc3csyh	281	1	In	in	IN
cord-270892-ycc3csyh	281	2	summary	summary	NN
cord-270892-ycc3csyh	281	3	,	,	,
cord-270892-ycc3csyh	281	4	the	the	DT
cord-270892-ycc3csyh	281	5	monoclonal	monoclonal	JJ
cord-270892-ycc3csyh	281	6	antibody	antibody	NN
cord-270892-ycc3csyh	281	7	to	to	IN
cord-270892-ycc3csyh	281	8	the	the	DT
cord-270892-ycc3csyh	281	9	cellular	cellular	JJ
cord-270892-ycc3csyh	281	10	ICAM-1	icam-1	NN
cord-270892-ycc3csyh	281	11	was	be	VBD
cord-270892-ycc3csyh	281	12	demonstrated	demonstrate	VBN
cord-270892-ycc3csyh	281	13	to	to	TO
cord-270892-ycc3csyh	281	14	be	be	VB
cord-270892-ycc3csyh	281	15	not	not	RB
cord-270892-ycc3csyh	281	16	effective	effective	JJ
cord-270892-ycc3csyh	281	17	enough	enough	RB
cord-270892-ycc3csyh	281	18	.	.	.
cord-270892-ycc3csyh	282	1	A	a	DT
cord-270892-ycc3csyh	282	2	new	new	JJ
cord-270892-ycc3csyh	282	3	strategy	strategy	NN
cord-270892-ycc3csyh	282	4	was	be	VBD
cord-270892-ycc3csyh	282	5	the	the	DT
cord-270892-ycc3csyh	282	6	creation	creation	NN
cord-270892-ycc3csyh	282	7	of	of	IN
cord-270892-ycc3csyh	282	8	multivalent	multivalent	JJ
cord-270892-ycc3csyh	282	9	Fab	Fab	NNP
cord-270892-ycc3csyh	282	10	fusion	fusion	NN
cord-270892-ycc3csyh	282	11	proteins	protein	NNS
cord-270892-ycc3csyh	282	12	against	against	IN
cord-270892-ycc3csyh	282	13	ICAM-1	ICAM-1	NNP
cord-270892-ycc3csyh	282	14	.	.	.
cord-270892-ycc3csyh	283	1	A	a	DT
cord-270892-ycc3csyh	283	2	new	new	JJ
cord-270892-ycc3csyh	283	3	molecule	molecule	NN
cord-270892-ycc3csyh	283	4	,	,	,
cord-270892-ycc3csyh	283	5	named	name	VBN
cord-270892-ycc3csyh	283	6	CFY196	CFY196	NNP
cord-270892-ycc3csyh	283	7	demonstrated	demonstrate	VBD
cord-270892-ycc3csyh	283	8	a	a	DT
cord-270892-ycc3csyh	283	9	better	well	JJR
cord-270892-ycc3csyh	283	10	avidity	avidity	NN
cord-270892-ycc3csyh	283	11	and	and	CC
cord-270892-ycc3csyh	283	12	in	in	IN
cord-270892-ycc3csyh	283	13	vitro	vitro	FW
cord-270892-ycc3csyh	283	14	potency	potency	NN
cord-270892-ycc3csyh	283	15	against	against	IN
cord-270892-ycc3csyh	283	16	HRV	HRV	NNP
cord-270892-ycc3csyh	283	17	over	over	IN
cord-270892-ycc3csyh	283	18	conventional	conventional	JJ
cord-270892-ycc3csyh	283	19	MAbs	MAbs	NNP
cord-270892-ycc3csyh	283	20	.	.	.
cord-270892-ycc3csyh	284	1	161	161	CD
cord-270892-ycc3csyh	284	2	CFY196	CFY196	NNS
cord-270892-ycc3csyh	284	3	is	be	VBZ
cord-270892-ycc3csyh	284	4	under	under	IN
cord-270892-ycc3csyh	284	5	development	development	NN
cord-270892-ycc3csyh	284	6	as	as	IN
cord-270892-ycc3csyh	284	7	nasal	nasal	NN
cord-270892-ycc3csyh	284	8	spray	spray	NN
cord-270892-ycc3csyh	284	9	with	with	IN
cord-270892-ycc3csyh	284	10	the	the	DT
cord-270892-ycc3csyh	284	11	name	name	NN
cord-270892-ycc3csyh	284	12	of	of	IN
cord-270892-ycc3csyh	284	13	ColdSol	ColdSol	NNP
cord-270892-ycc3csyh	284	14	.	.	.
cord-270892-ycc3csyh	285	1	Antagonism	antagonism	NN
cord-270892-ycc3csyh	285	2	of	of	IN
cord-270892-ycc3csyh	285	3	virus	virus	NN
cord-270892-ycc3csyh	285	4	-	-	HYPH
cord-270892-ycc3csyh	285	5	receptor	receptor	NN
cord-270892-ycc3csyh	285	6	interaction	interaction	NN
cord-270892-ycc3csyh	285	7	was	be	VBD
cord-270892-ycc3csyh	285	8	considered	consider	VBN
cord-270892-ycc3csyh	285	9	as	as	IN
cord-270892-ycc3csyh	285	10	another	another	DT
cord-270892-ycc3csyh	285	11	promising	promising	JJ
cord-270892-ycc3csyh	285	12	way	way	NN
cord-270892-ycc3csyh	285	13	to	to	TO
cord-270892-ycc3csyh	285	14	prevent	prevent	VB
cord-270892-ycc3csyh	285	15	HRV	HRV	NNP
cord-270892-ycc3csyh	285	16	attachment	attachment	NN
cord-270892-ycc3csyh	285	17	to	to	TO
cord-270892-ycc3csyh	285	18	host	host	NN
cord-270892-ycc3csyh	285	19	cells	cell	NNS
cord-270892-ycc3csyh	285	20	.	.	.
cord-270892-ycc3csyh	286	1	Soluble	soluble	JJ
cord-270892-ycc3csyh	286	2	forms	form	NNS
cord-270892-ycc3csyh	286	3	of	of	IN
cord-270892-ycc3csyh	286	4	fully	fully	RB
cord-270892-ycc3csyh	286	5	or	or	CC
cord-270892-ycc3csyh	286	6	truncated	truncate	VBN
cord-270892-ycc3csyh	286	7	ICAM-1	icam-1	NN
cord-270892-ycc3csyh	286	8	,	,	,
cord-270892-ycc3csyh	286	9	[	[	-LRB-
cord-270892-ycc3csyh	286	10	162	162	CD
cord-270892-ycc3csyh	286	11	]	]	-RRB-
cord-270892-ycc3csyh	286	12	[	[	-LRB-
cord-270892-ycc3csyh	286	13	163	163	CD
cord-270892-ycc3csyh	286	14	]	]	-RRB-
cord-270892-ycc3csyh	286	15	[	[	-LRB-
cord-270892-ycc3csyh	286	16	164	164	CD
cord-270892-ycc3csyh	286	17	]	]	-RRB-
cord-270892-ycc3csyh	286	18	and	and	CC
cord-270892-ycc3csyh	286	19	LDL	LDL	NNP
cord-270892-ycc3csyh	286	20	or	or	CC
cord-270892-ycc3csyh	286	21	VLDL	vldl	NN
cord-270892-ycc3csyh	286	22	-	-	HYPH
cord-270892-ycc3csyh	286	23	receptor	receptor	NN
cord-270892-ycc3csyh	286	24	concatemers	concatemer	NNS
cord-270892-ycc3csyh	286	25	[	[	-LRB-
cord-270892-ycc3csyh	286	26	165	165	CD
cord-270892-ycc3csyh	286	27	]	]	-RRB-
cord-270892-ycc3csyh	286	28	[	[	-LRB-
cord-270892-ycc3csyh	286	29	166	166	CD
cord-270892-ycc3csyh	286	30	]	]	-RRB-
cord-270892-ycc3csyh	286	31	[	[	-LRB-
cord-270892-ycc3csyh	286	32	167	167	CD
cord-270892-ycc3csyh	286	33	]	]	-RRB-
cord-270892-ycc3csyh	286	34	exhibited	exhibit	VBN
cord-270892-ycc3csyh	286	35	antiviral	antiviral	JJ
cord-270892-ycc3csyh	286	36	activity	activity	NN
cord-270892-ycc3csyh	286	37	against	against	IN
cord-270892-ycc3csyh	286	38	major	major	JJ
cord-270892-ycc3csyh	286	39	and	and	CC
cord-270892-ycc3csyh	286	40	minor	minor	JJ
cord-270892-ycc3csyh	286	41	group	group	NN
cord-270892-ycc3csyh	286	42	HRV	HRV	NNP
cord-270892-ycc3csyh	286	43	,	,	,
cord-270892-ycc3csyh	286	44	respectively	respectively	RB
cord-270892-ycc3csyh	286	45	,	,	,
cord-270892-ycc3csyh	286	46	in	in	IN
cord-270892-ycc3csyh	286	47	cell	cell	NN
cord-270892-ycc3csyh	286	48	culture	culture	NN
cord-270892-ycc3csyh	286	49	.	.	.
cord-270892-ycc3csyh	287	1	Soluble	soluble	JJ
cord-270892-ycc3csyh	287	2	forms	form	NNS
cord-270892-ycc3csyh	287	3	of	of	IN
cord-270892-ycc3csyh	287	4	ICAM-1	icam-1	NN
cord-270892-ycc3csyh	287	5	compete	compete	VBP
cord-270892-ycc3csyh	287	6	with	with	IN
cord-270892-ycc3csyh	287	7	receptor	receptor	NN
cord-270892-ycc3csyh	287	8	binding	bind	VBG
cord-270892-ycc3csyh	287	9	sites	site	NNS
cord-270892-ycc3csyh	287	10	on	on	IN
cord-270892-ycc3csyh	287	11	the	the	DT
cord-270892-ycc3csyh	287	12	virus	virus	NN
cord-270892-ycc3csyh	287	13	capsid	capsid	NN
cord-270892-ycc3csyh	287	14	,	,	,
cord-270892-ycc3csyh	287	15	hinder	hinder	VB
cord-270892-ycc3csyh	287	16	an	an	DT
cord-270892-ycc3csyh	287	17	early	early	JJ
cord-270892-ycc3csyh	287	18	infection	infection	NN
cord-270892-ycc3csyh	287	19	event	event	NN
cord-270892-ycc3csyh	287	20	such	such	JJ
cord-270892-ycc3csyh	287	21	as	as	IN
cord-270892-ycc3csyh	287	22	entry	entry	NN
cord-270892-ycc3csyh	287	23	or	or	CC
cord-270892-ycc3csyh	287	24	uncoating	uncoating	NN
cord-270892-ycc3csyh	287	25	,	,	,
cord-270892-ycc3csyh	287	26	or	or	CC
cord-270892-ycc3csyh	287	27	directly	directly	RB
cord-270892-ycc3csyh	287	28	inactivate	inactivate	VB
cord-270892-ycc3csyh	287	29	HRV	HRV	NNP
cord-270892-ycc3csyh	287	30	due	due	IN
cord-270892-ycc3csyh	287	31	to	to	IN
cord-270892-ycc3csyh	287	32	the	the	DT
cord-270892-ycc3csyh	287	33	formation	formation	NN
cord-270892-ycc3csyh	287	34	of	of	IN
cord-270892-ycc3csyh	287	35	empty	empty	JJ
cord-270892-ycc3csyh	287	36	capsids	capsid	NNS
cord-270892-ycc3csyh	287	37	.	.	.
cord-270892-ycc3csyh	288	1	163	163	CD
cord-270892-ycc3csyh	288	2	,	,	,
cord-270892-ycc3csyh	288	3	[	[	-LRB-
cord-270892-ycc3csyh	288	4	168	168	CD
cord-270892-ycc3csyh	288	5	]	]	-RRB-
cord-270892-ycc3csyh	288	6	[	[	-LRB-
cord-270892-ycc3csyh	288	7	169	169	CD
cord-270892-ycc3csyh	288	8	]	]	-RRB-
cord-270892-ycc3csyh	288	9	[	[	-LRB-
cord-270892-ycc3csyh	288	10	170	170	CD
cord-270892-ycc3csyh	288	11	]	]	-RRB-
cord-270892-ycc3csyh	289	1	A	a	DT
cord-270892-ycc3csyh	289	2	soluble	soluble	JJ
cord-270892-ycc3csyh	289	3	LDL	ldl	NN
cord-270892-ycc3csyh	289	4	receptor	receptor	NN
cord-270892-ycc3csyh	289	5	fragment	fragment	NN
cord-270892-ycc3csyh	289	6	neutralized	neutralize	VBD
cord-270892-ycc3csyh	289	7	viral	viral	JJ
cord-270892-ycc3csyh	289	8	infectivity	infectivity	NN
cord-270892-ycc3csyh	289	9	by	by	IN
cord-270892-ycc3csyh	289	10	aggregation	aggregation	NN
cord-270892-ycc3csyh	289	11	.	.	.
cord-270892-ycc3csyh	290	1	171	171	CD
cord-270892-ycc3csyh	290	2	Concatemers	Concatemers	NNPS
cord-270892-ycc3csyh	290	3	of	of	IN
cord-270892-ycc3csyh	290	4	the	the	DT
cord-270892-ycc3csyh	290	5	third	third	JJ
cord-270892-ycc3csyh	290	6	ligand	ligand	NN
cord-270892-ycc3csyh	290	7	binding	binding	NN
cord-270892-ycc3csyh	290	8	module	module	NN
cord-270892-ycc3csyh	290	9	of	of	IN
cord-270892-ycc3csyh	290	10	the	the	DT
cord-270892-ycc3csyh	290	11	VLDL	vldl	NN
cord-270892-ycc3csyh	290	12	-	-	HYPH
cord-270892-ycc3csyh	290	13	receptor	receptor	NN
cord-270892-ycc3csyh	290	14	did	do	VBD
cord-270892-ycc3csyh	290	15	not	not	RB
cord-270892-ycc3csyh	290	16	lead	lead	VB
cord-270892-ycc3csyh	290	17	to	to	IN
cord-270892-ycc3csyh	290	18	viral	viral	JJ
cord-270892-ycc3csyh	290	19	aggregation	aggregation	NN
cord-270892-ycc3csyh	290	20	but	but	CC
cord-270892-ycc3csyh	290	21	blocked	block	VBD
cord-270892-ycc3csyh	290	22	the	the	DT
cord-270892-ycc3csyh	290	23	receptor	receptor	NN
cord-270892-ycc3csyh	290	24	binding	bind	VBG
cord-270892-ycc3csyh	290	25	sites	site	NNS
cord-270892-ycc3csyh	290	26	and	and	CC
cord-270892-ycc3csyh	290	27	possibly	possibly	RB
cord-270892-ycc3csyh	290	28	inhibited	inhibited	JJ
cord-270892-ycc3csyh	290	29	viral	viral	JJ
cord-270892-ycc3csyh	290	30	uncoating	uncoating	NN
cord-270892-ycc3csyh	290	31	by	by	IN
cord-270892-ycc3csyh	290	32	cross	cross	NN
cord-270892-ycc3csyh	290	33	-	-	JJ
cord-270892-ycc3csyh	290	34	linking	link	VBG
cord-270892-ycc3csyh	290	35	the	the	DT
cord-270892-ycc3csyh	290	36	viral	viral	JJ
cord-270892-ycc3csyh	290	37	capsid	capsid	NN
cord-270892-ycc3csyh	290	38	subunits	subunit	NNS
cord-270892-ycc3csyh	290	39	via	via	IN
cord-270892-ycc3csyh	290	40	multi	multi	JJ
cord-270892-ycc3csyh	290	41	-	-	JJ
cord-270892-ycc3csyh	290	42	module	module	NN
cord-270892-ycc3csyh	290	43	binding	binding	NN
cord-270892-ycc3csyh	290	44	.	.	.
cord-270892-ycc3csyh	291	1	166	166	CD
cord-270892-ycc3csyh	292	1	The	the	DT
cord-270892-ycc3csyh	292	2	antiviral	antiviral	JJ
cord-270892-ycc3csyh	292	3	activity	activity	NN
cord-270892-ycc3csyh	292	4	of	of	IN
cord-270892-ycc3csyh	292	5	a	a	DT
cord-270892-ycc3csyh	292	6	truncated	truncated	JJ
cord-270892-ycc3csyh	292	7	,	,	,
cord-270892-ycc3csyh	292	8	soluble	soluble	JJ
cord-270892-ycc3csyh	292	9	form	form	NN
cord-270892-ycc3csyh	292	10	of	of	IN
cord-270892-ycc3csyh	292	11	ICAM-1	icam-1	NN
cord-270892-ycc3csyh	292	12	was	be	VBD
cord-270892-ycc3csyh	292	13	proved	prove	VBN
cord-270892-ycc3csyh	292	14	in	in	IN
cord-270892-ycc3csyh	292	15	HRV-16	HRV-16	NNP
cord-270892-ycc3csyh	292	16	infected	infect	VBN
cord-270892-ycc3csyh	292	17	chimpanzee	chimpanzee	NN
cord-270892-ycc3csyh	292	18	.	.	.
cord-270892-ycc3csyh	293	1	172	172	CD
cord-270892-ycc3csyh	294	1	In	in	IN
cord-270892-ycc3csyh	294	2	randomized	randomized	JJ
cord-270892-ycc3csyh	294	3	,	,	,
cord-270892-ycc3csyh	294	4	double	double	JJ
cord-270892-ycc3csyh	294	5	-	-	HYPH
cord-270892-ycc3csyh	294	6	blind	blind	JJ
cord-270892-ycc3csyh	294	7	,	,	,
cord-270892-ycc3csyh	294	8	placebo	placebo	NN
cord-270892-ycc3csyh	294	9	-	-	HYPH
cord-270892-ycc3csyh	294	10	controlled	control	VBN
cord-270892-ycc3csyh	294	11	trials	trial	NNS
cord-270892-ycc3csyh	294	12	,	,	,
cord-270892-ycc3csyh	294	13	the	the	DT
cord-270892-ycc3csyh	294	14	safety	safety	NN
cord-270892-ycc3csyh	294	15	and	and	CC
cord-270892-ycc3csyh	294	16	efficacy	efficacy	NN
cord-270892-ycc3csyh	294	17	of	of	IN
cord-270892-ycc3csyh	294	18	intranasal	intranasal	NNP
cord-270892-ycc3csyh	294	19	administration	administration	NNP
cord-270892-ycc3csyh	294	20	of	of	IN
cord-270892-ycc3csyh	294	21	tremacamra	tremacamra	NNP
cord-270892-ycc3csyh	294	22	,	,	,
cord-270892-ycc3csyh	294	23	a	a	DT
cord-270892-ycc3csyh	294	24	soluble	soluble	JJ
cord-270892-ycc3csyh	294	25	ICAM-1	icam-1	NN
cord-270892-ycc3csyh	294	26	in	in	IN
cord-270892-ycc3csyh	294	27	experimental	experimental	JJ
cord-270892-ycc3csyh	294	28	HRV-39-induced	hrv-39-induced	JJ
cord-270892-ycc3csyh	294	29	colds	cold	NNS
cord-270892-ycc3csyh	294	30	in	in	IN
cord-270892-ycc3csyh	294	31	humans	human	NNS
cord-270892-ycc3csyh	294	32	,	,	,
cord-270892-ycc3csyh	294	33	was	be	VBD
cord-270892-ycc3csyh	294	34	shown	show	VBN
cord-270892-ycc3csyh	294	35	.	.	.
cord-270892-ycc3csyh	295	1	173	173	CD
cord-270892-ycc3csyh	296	1	No	no	DT
cord-270892-ycc3csyh	296	2	further	further	JJ
cord-270892-ycc3csyh	296	3	development	development	NN
cord-270892-ycc3csyh	296	4	was	be	VBD
cord-270892-ycc3csyh	296	5	reported	report	VBN
cord-270892-ycc3csyh	296	6	for	for	IN
cord-270892-ycc3csyh	296	7	these	these	DT
cord-270892-ycc3csyh	296	8	agents	agent	NNS
cord-270892-ycc3csyh	296	9	.	.	.
cord-270892-ycc3csyh	297	1	95	95	CD
cord-270892-ycc3csyh	298	1	A	a	DT
cord-270892-ycc3csyh	298	2	further	further	JJ
cord-270892-ycc3csyh	298	3	option	option	NN
cord-270892-ycc3csyh	298	4	to	to	TO
cord-270892-ycc3csyh	298	5	prevent	prevent	VB
cord-270892-ycc3csyh	298	6	virus	virus	NN
cord-270892-ycc3csyh	298	7	attachment	attachment	NN
cord-270892-ycc3csyh	298	8	was	be	VBD
cord-270892-ycc3csyh	298	9	described	describe	VBN
cord-270892-ycc3csyh	298	10	for	for	IN
cord-270892-ycc3csyh	298	11	low	low	JJ
cord-270892-ycc3csyh	298	12	-	-	HYPH
cord-270892-ycc3csyh	298	13	molecular	molecular	JJ
cord-270892-ycc3csyh	298	14	-	-	HYPH
cord-270892-ycc3csyh	298	15	weight	weight	NN
cord-270892-ycc3csyh	298	16	compounds	compound	NNS
cord-270892-ycc3csyh	298	17	,	,	,
cord-270892-ycc3csyh	298	18	the	the	DT
cord-270892-ycc3csyh	298	19	so	so	RB
cord-270892-ycc3csyh	298	20	-	-	HYPH
cord-270892-ycc3csyh	298	21	called	call	VBN
cord-270892-ycc3csyh	298	22	capsid	capsid	RB
cord-270892-ycc3csyh	298	23	-	-	HYPH
cord-270892-ycc3csyh	298	24	binding	bind	VBG
cord-270892-ycc3csyh	298	25	agents	agent	NNS
cord-270892-ycc3csyh	298	26	,	,	,
cord-270892-ycc3csyh	298	27	which	which	WDT
cord-270892-ycc3csyh	298	28	enter	enter	VBP
cord-270892-ycc3csyh	298	29	the	the	DT
cord-270892-ycc3csyh	298	30	small	small	JJ
cord-270892-ycc3csyh	298	31	hydrophobic	hydrophobic	JJ
cord-270892-ycc3csyh	298	32	pocket	pocket	NN
cord-270892-ycc3csyh	298	33	within	within	IN
cord-270892-ycc3csyh	298	34	viral	viral	JJ
cord-270892-ycc3csyh	298	35	capsid	capsid	NN
cord-270892-ycc3csyh	298	36	protein	protein	NN
cord-270892-ycc3csyh	298	37	1	1	CD
cord-270892-ycc3csyh	298	38	beneath	beneath	IN
cord-270892-ycc3csyh	298	39	the	the	DT
cord-270892-ycc3csyh	298	40	ICAM	ICAM	NNP
cord-270892-ycc3csyh	298	41	-	-	HYPH
cord-270892-ycc3csyh	298	42	binding	bind	VBG
cord-270892-ycc3csyh	298	43	canyon	canyon	NN
cord-270892-ycc3csyh	298	44	of	of	IN
cord-270892-ycc3csyh	298	45	HRV	HRV	NNP
cord-270892-ycc3csyh	298	46	.	.	.
cord-270892-ycc3csyh	299	1	174	174	CD
cord-270892-ycc3csyh	300	1	,	,	,
cord-270892-ycc3csyh	300	2	175	175	CD
cord-270892-ycc3csyh	300	3	Zhang	Zhang	NNP
cord-270892-ycc3csyh	300	4	et	et	NNP
cord-270892-ycc3csyh	300	5	al	al	NNP
cord-270892-ycc3csyh	300	6	.	.	.
cord-270892-ycc3csyh	301	1	showed	show	VBD
cord-270892-ycc3csyh	301	2	that	that	IN
cord-270892-ycc3csyh	301	3	drug	drug	NN
cord-270892-ycc3csyh	301	4	may	may	MD
cord-270892-ycc3csyh	301	5	integrate	integrate	VB
cord-270892-ycc3csyh	301	6	into	into	IN
cord-270892-ycc3csyh	301	7	mature	mature	JJ
cord-270892-ycc3csyh	301	8	viruses	virus	NNS
cord-270892-ycc3csyh	301	9	by	by	IN
cord-270892-ycc3csyh	301	10	diffusion	diffusion	NN
cord-270892-ycc3csyh	301	11	as	as	RB
cord-270892-ycc3csyh	301	12	well	well	RB
cord-270892-ycc3csyh	301	13	as	as	IN
cord-270892-ycc3csyh	301	14	into	into	IN
cord-270892-ycc3csyh	301	15	progeny	progeny	NN
cord-270892-ycc3csyh	301	16	viruses	virus	NNS
cord-270892-ycc3csyh	301	17	during	during	IN
cord-270892-ycc3csyh	301	18	assembly	assembly	NN
cord-270892-ycc3csyh	301	19	.	.	.
cord-270892-ycc3csyh	302	1	176	176	CD
cord-270892-ycc3csyh	303	1	When	when	WRB
cord-270892-ycc3csyh	303	2	HRV-14	HRV-14	NNP
cord-270892-ycc3csyh	303	3	and	and	CC
cord-270892-ycc3csyh	303	4	HRV-16	HRV-16	NNP
cord-270892-ycc3csyh	303	5	were	be	VBD
cord-270892-ycc3csyh	303	6	grown	grow	VBN
cord-270892-ycc3csyh	303	7	in	in	IN
cord-270892-ycc3csyh	303	8	the	the	DT
cord-270892-ycc3csyh	303	9	presence	presence	NN
cord-270892-ycc3csyh	303	10	of	of	IN
cord-270892-ycc3csyh	303	11	pleconaril	pleconaril	NNP
cord-270892-ycc3csyh	303	12	,	,	,
cord-270892-ycc3csyh	303	13	a	a	DT
cord-270892-ycc3csyh	303	14	higher	high	JJR
cord-270892-ycc3csyh	303	15	occupancy	occupancy	NN
cord-270892-ycc3csyh	303	16	occurred	occur	VBD
cord-270892-ycc3csyh	303	17	than	than	IN
cord-270892-ycc3csyh	303	18	when	when	WRB
cord-270892-ycc3csyh	303	19	the	the	DT
cord-270892-ycc3csyh	303	20	drug	drug	NN
cord-270892-ycc3csyh	303	21	was	be	VBD
cord-270892-ycc3csyh	303	22	introduced	introduce	VBN
cord-270892-ycc3csyh	303	23	into	into	IN
cord-270892-ycc3csyh	303	24	the	the	DT
cord-270892-ycc3csyh	303	25	alreadyassembled	alreadyassemble	VBN
cord-270892-ycc3csyh	303	26	viruses	virus	NNS
cord-270892-ycc3csyh	303	27	.	.	.
cord-270892-ycc3csyh	304	1	In	in	IN
cord-270892-ycc3csyh	304	2	doing	do	VBG
cord-270892-ycc3csyh	304	3	so	so	RB
cord-270892-ycc3csyh	304	4	,	,	,
cord-270892-ycc3csyh	304	5	capsid	capsid	NN
cord-270892-ycc3csyh	304	6	-	-	HYPH
cord-270892-ycc3csyh	304	7	binders	binder	NNS
cord-270892-ycc3csyh	304	8	induce	induce	VBP
cord-270892-ycc3csyh	304	9	conformational	conformational	JJ
cord-270892-ycc3csyh	304	10	changes	change	NNS
cord-270892-ycc3csyh	304	11	of	of	IN
cord-270892-ycc3csyh	304	12	the	the	DT
cord-270892-ycc3csyh	304	13	canyon	canyon	NN
cord-270892-ycc3csyh	304	14	of	of	IN
cord-270892-ycc3csyh	304	15	HRV-3	HRV-3	NNP
cord-270892-ycc3csyh	304	16	and	and	CC
cord-270892-ycc3csyh	304	17	HRV-14	HRV-14	NNP
cord-270892-ycc3csyh	304	18	,	,	,
cord-270892-ycc3csyh	304	19	hinder	hinder	VBP
cord-270892-ycc3csyh	304	20	virus	virus	NN
cord-270892-ycc3csyh	304	21	-	-	HYPH
cord-270892-ycc3csyh	304	22	receptor	receptor	NN
cord-270892-ycc3csyh	304	23	interactions	interaction	NNS
cord-270892-ycc3csyh	304	24	,	,	,
cord-270892-ycc3csyh	304	25	and	and	CC
cord-270892-ycc3csyh	304	26	prevent	prevent	VB
cord-270892-ycc3csyh	304	27	attachment	attachment	NN
cord-270892-ycc3csyh	304	28	to	to	TO
cord-270892-ycc3csyh	304	29	host	host	NN
cord-270892-ycc3csyh	304	30	cells	cell	NNS
cord-270892-ycc3csyh	304	31	.	.	.
cord-270892-ycc3csyh	305	1	105	105	CD
cord-270892-ycc3csyh	305	2	,	,	,
cord-270892-ycc3csyh	305	3	175	175	CD
cord-270892-ycc3csyh	305	4	,	,	,
cord-270892-ycc3csyh	305	5	[	[	-LRB-
cord-270892-ycc3csyh	305	6	177	177	CD
cord-270892-ycc3csyh	305	7	]	]	-RRB-
cord-270892-ycc3csyh	305	8	[	[	-LRB-
cord-270892-ycc3csyh	305	9	178	178	CD
cord-270892-ycc3csyh	305	10	]	]	-RRB-
cord-270892-ycc3csyh	305	11	[	[	-LRB-
cord-270892-ycc3csyh	305	12	179	179	CD
cord-270892-ycc3csyh	305	13	]	]	-RRB-
cord-270892-ycc3csyh	306	1	In	in	IN
cord-270892-ycc3csyh	306	2	addition	addition	NN
cord-270892-ycc3csyh	306	3	,	,	,
cord-270892-ycc3csyh	306	4	uncoating	uncoate	VBG
cord-270892-ycc3csyh	306	5	of	of	IN
cord-270892-ycc3csyh	306	6	both	both	CC
cord-270892-ycc3csyh	306	7	HRV	HRV	NNP
cord-270892-ycc3csyh	306	8	serotypes	serotype	NNS
cord-270892-ycc3csyh	306	9	was	be	VBD
cord-270892-ycc3csyh	306	10	shown	show	VBN
cord-270892-ycc3csyh	306	11	to	to	TO
cord-270892-ycc3csyh	306	12	be	be	VB
cord-270892-ycc3csyh	306	13	inhibited	inhibit	VBN
cord-270892-ycc3csyh	306	14	as	as	IN
cord-270892-ycc3csyh	306	15	a	a	DT
cord-270892-ycc3csyh	306	16	result	result	NN
cord-270892-ycc3csyh	306	17	of	of	IN
cord-270892-ycc3csyh	306	18	a	a	DT
cord-270892-ycc3csyh	306	19	potential	potential	JJ
cord-270892-ycc3csyh	306	20	loss	loss	NN
cord-270892-ycc3csyh	306	21	of	of	IN
cord-270892-ycc3csyh	306	22	flexibility	flexibility	NN
cord-270892-ycc3csyh	306	23	of	of	IN
cord-270892-ycc3csyh	306	24	the	the	DT
cord-270892-ycc3csyh	306	25	viral	viral	JJ
cord-270892-ycc3csyh	306	26	capsid	capsid	NN
cord-270892-ycc3csyh	306	27	after	after	IN
cord-270892-ycc3csyh	306	28	drug	drug	NN
cord-270892-ycc3csyh	306	29	binding	binding	NN
cord-270892-ycc3csyh	306	30	.	.	.
cord-270892-ycc3csyh	307	1	In	in	IN
cord-270892-ycc3csyh	307	2	contrast	contrast	NN
cord-270892-ycc3csyh	307	3	to	to	IN
cord-270892-ycc3csyh	307	4	HRV-3	HRV-3	NNP
cord-270892-ycc3csyh	307	5	and	and	CC
cord-270892-ycc3csyh	307	6	HRV-14	HRV-14	NNP
cord-270892-ycc3csyh	307	7	,	,	,
cord-270892-ycc3csyh	307	8	capsid	capsid	RB
cord-270892-ycc3csyh	307	9	-	-	HYPH
cord-270892-ycc3csyh	307	10	binding	bind	VBG
cord-270892-ycc3csyh	307	11	compounds	compound	NNS
cord-270892-ycc3csyh	307	12	did	do	VBD
cord-270892-ycc3csyh	307	13	not	not	RB
cord-270892-ycc3csyh	307	14	prevent	prevent	VB
cord-270892-ycc3csyh	307	15	attachment	attachment	NN
cord-270892-ycc3csyh	307	16	of	of	IN
cord-270892-ycc3csyh	307	17	HRV-1A.	HRV-1A.	NNS
cord-270892-ycc3csyh	307	18	Results	result	NNS
cord-270892-ycc3csyh	307	19	from	from	IN
cord-270892-ycc3csyh	307	20	X	x	NN
cord-270892-ycc3csyh	307	21	-	-	NN
cord-270892-ycc3csyh	307	22	ray	ray	NN
cord-270892-ycc3csyh	307	23	studies	study	NNS
cord-270892-ycc3csyh	307	24	showed	show	VBD
cord-270892-ycc3csyh	307	25	that	that	IN
cord-270892-ycc3csyh	307	26	drug	drug	NN
cord-270892-ycc3csyh	307	27	binding	bind	VBG
cord-270892-ycc3csyh	307	28	into	into	IN
cord-270892-ycc3csyh	307	29	the	the	DT
cord-270892-ycc3csyh	307	30	hydrophobic	hydrophobic	JJ
cord-270892-ycc3csyh	307	31	pocket	pocket	NN
cord-270892-ycc3csyh	307	32	of	of	IN
cord-270892-ycc3csyh	307	33	HRV-1A	HRV-1A	NNP
cord-270892-ycc3csyh	307	34	replaces	replace	VBZ
cord-270892-ycc3csyh	307	35	the	the	DT
cord-270892-ycc3csyh	307	36	pocket	pocket	NN
cord-270892-ycc3csyh	307	37	factor	factor	NN
cord-270892-ycc3csyh	307	38	but	but	CC
cord-270892-ycc3csyh	307	39	induces	induce	VBZ
cord-270892-ycc3csyh	307	40	only	only	RB
cord-270892-ycc3csyh	307	41	very	very	RB
cord-270892-ycc3csyh	307	42	small	small	JJ
cord-270892-ycc3csyh	307	43	conformational	conformational	JJ
cord-270892-ycc3csyh	307	44	changes	change	NNS
cord-270892-ycc3csyh	307	45	.	.	.
cord-270892-ycc3csyh	308	1	180	180	CD
cord-270892-ycc3csyh	309	1	Therefore	therefore	RB
cord-270892-ycc3csyh	309	2	,	,	,
cord-270892-ycc3csyh	309	3	Kim	Kim	NNP
cord-270892-ycc3csyh	309	4	et	et	NNP
cord-270892-ycc3csyh	309	5	al	al	NNP
cord-270892-ycc3csyh	309	6	.	.	NNP
cord-270892-ycc3csyh	309	7	suggested	suggest	VBD
cord-270892-ycc3csyh	309	8	that	that	IN
cord-270892-ycc3csyh	309	9	the	the	DT
cord-270892-ycc3csyh	309	10	observed	observed	JJ
cord-270892-ycc3csyh	309	11	conformational	conformational	JJ
cord-270892-ycc3csyh	309	12	changes	change	NNS
cord-270892-ycc3csyh	309	13	are	be	VBP
cord-270892-ycc3csyh	309	14	too	too	RB
cord-270892-ycc3csyh	309	15	small	small	JJ
cord-270892-ycc3csyh	309	16	to	to	TO
cord-270892-ycc3csyh	309	17	affect	affect	VB
cord-270892-ycc3csyh	309	18	receptor	receptor	NN
cord-270892-ycc3csyh	309	19	binding	binding	NN
cord-270892-ycc3csyh	309	20	.	.	.
cord-270892-ycc3csyh	310	1	But	but	CC
cord-270892-ycc3csyh	310	2	,	,	,
cord-270892-ycc3csyh	310	3	capsid	capsid	RB
cord-270892-ycc3csyh	310	4	-	-	HYPH
cord-270892-ycc3csyh	310	5	binding	bind	VBG
cord-270892-ycc3csyh	310	6	compounds	compound	NNS
cord-270892-ycc3csyh	310	7	prevented	prevent	VBD
cord-270892-ycc3csyh	310	8	attachment	attachment	NN
cord-270892-ycc3csyh	310	9	of	of	IN
cord-270892-ycc3csyh	310	10	HRV-16	HRV-16	NNP
cord-270892-ycc3csyh	310	11	possessing	possess	VBG
cord-270892-ycc3csyh	310	12	a	a	DT
cord-270892-ycc3csyh	310	13	pocket	pocket	NN
cord-270892-ycc3csyh	310	14	factor	factor	NN
cord-270892-ycc3csyh	310	15	like	like	IN
cord-270892-ycc3csyh	310	16	HRV-1A	HRV-1A	NNP
cord-270892-ycc3csyh	310	17	without	without	IN
cord-270892-ycc3csyh	310	18	distinct	distinct	JJ
cord-270892-ycc3csyh	310	19	deformation	deformation	NN
cord-270892-ycc3csyh	310	20	of	of	IN
cord-270892-ycc3csyh	310	21	the	the	DT
cord-270892-ycc3csyh	310	22	pocket	pocket	NN
cord-270892-ycc3csyh	310	23	.	.	.
cord-270892-ycc3csyh	311	1	102	102	CD
cord-270892-ycc3csyh	311	2	,	,	,
cord-270892-ycc3csyh	311	3	176	176	CD
cord-270892-ycc3csyh	311	4	,	,	,
cord-270892-ycc3csyh	311	5	181	181	CD
cord-270892-ycc3csyh	311	6	Further	further	JJ
cord-270892-ycc3csyh	311	7	results	result	NNS
cord-270892-ycc3csyh	311	8	from	from	IN
cord-270892-ycc3csyh	311	9	comparative	comparative	JJ
cord-270892-ycc3csyh	311	10	antiviral	antiviral	JJ
cord-270892-ycc3csyh	311	11	studies	study	NNS
cord-270892-ycc3csyh	311	12	with	with	IN
cord-270892-ycc3csyh	311	13	different	different	JJ
cord-270892-ycc3csyh	311	14	capsid	capsid	RB
cord-270892-ycc3csyh	311	15	-	-	HYPH
cord-270892-ycc3csyh	311	16	binding	bind	VBG
cord-270892-ycc3csyh	311	17	compounds	compound	NNS
cord-270892-ycc3csyh	311	18	and	and	CC
cord-270892-ycc3csyh	311	19	HRV	HRV	NNP
cord-270892-ycc3csyh	311	20	,	,	,
cord-270892-ycc3csyh	311	21	representative	representative	NN
cord-270892-ycc3csyh	311	22	for	for	IN
cord-270892-ycc3csyh	311	23	the	the	DT
cord-270892-ycc3csyh	311	24	major	major	JJ
cord-270892-ycc3csyh	311	25	and	and	CC
cord-270892-ycc3csyh	311	26	minor	minor	JJ
cord-270892-ycc3csyh	311	27	group	group	NN
cord-270892-ycc3csyh	311	28	,	,	,
cord-270892-ycc3csyh	311	29	did	do	VBD
cord-270892-ycc3csyh	311	30	not	not	RB
cord-270892-ycc3csyh	311	31	reveal	reveal	VB
cord-270892-ycc3csyh	311	32	a	a	DT
cord-270892-ycc3csyh	311	33	correlation	correlation	NN
cord-270892-ycc3csyh	311	34	between	between	IN
cord-270892-ycc3csyh	311	35	inhibition	inhibition	NN
cord-270892-ycc3csyh	311	36	of	of	IN
cord-270892-ycc3csyh	311	37	adsorption	adsorption	NN
cord-270892-ycc3csyh	311	38	and	and	CC
cord-270892-ycc3csyh	311	39	receptor	receptor	NN
cord-270892-ycc3csyh	311	40	grouping	grouping	NN
cord-270892-ycc3csyh	311	41	or	or	CC
cord-270892-ycc3csyh	311	42	antiviral	antiviral	JJ
cord-270892-ycc3csyh	311	43	grouping	grouping	NN
cord-270892-ycc3csyh	311	44	.	.	.
cord-270892-ycc3csyh	312	1	182	182	CD
cord-270892-ycc3csyh	313	1	The	the	DT
cord-270892-ycc3csyh	313	2	reasons	reason	NNS
cord-270892-ycc3csyh	313	3	for	for	IN
cord-270892-ycc3csyh	313	4	the	the	DT
cord-270892-ycc3csyh	313	5	difference	difference	NN
cord-270892-ycc3csyh	313	6	in	in	IN
cord-270892-ycc3csyh	313	7	the	the	DT
cord-270892-ycc3csyh	313	8	mode	mode	NN
cord-270892-ycc3csyh	313	9	of	of	IN
cord-270892-ycc3csyh	313	10	action	action	NN
cord-270892-ycc3csyh	313	11	of	of	IN
cord-270892-ycc3csyh	313	12	capsid	capsid	RB
cord-270892-ycc3csyh	313	13	-	-	HYPH
cord-270892-ycc3csyh	313	14	binding	bind	VBG
cord-270892-ycc3csyh	313	15	compounds	compound	NNS
cord-270892-ycc3csyh	313	16	related	relate	VBN
cord-270892-ycc3csyh	313	17	to	to	IN
cord-270892-ycc3csyh	313	18	attachment	attachment	NN
cord-270892-ycc3csyh	313	19	inhibition	inhibition	NN
cord-270892-ycc3csyh	313	20	are	be	VBP
cord-270892-ycc3csyh	313	21	not	not	RB
cord-270892-ycc3csyh	313	22	fully	fully	RB
cord-270892-ycc3csyh	313	23	understood	understand	VBN
cord-270892-ycc3csyh	313	24	until	until	IN
cord-270892-ycc3csyh	313	25	now	now	RB
cord-270892-ycc3csyh	313	26	.	.	.
cord-270892-ycc3csyh	314	1	Taken	take	VBN
cord-270892-ycc3csyh	314	2	together	together	RB
cord-270892-ycc3csyh	314	3	,	,	,
cord-270892-ycc3csyh	314	4	inhibition	inhibition	NN
cord-270892-ycc3csyh	314	5	of	of	IN
cord-270892-ycc3csyh	314	6	RNA	RNA	NNP
cord-270892-ycc3csyh	314	7	uncoating	uncoating	NN
cord-270892-ycc3csyh	314	8	was	be	VBD
cord-270892-ycc3csyh	314	9	found	find	VBN
cord-270892-ycc3csyh	314	10	for	for	IN
cord-270892-ycc3csyh	314	11	all	all	DT
cord-270892-ycc3csyh	314	12	investigated	investigate	VBN
cord-270892-ycc3csyh	314	13	serotypes	serotype	NNS
cord-270892-ycc3csyh	314	14	after	after	IN
cord-270892-ycc3csyh	314	15	drug	drug	NN
cord-270892-ycc3csyh	314	16	binding	bind	VBG
cord-270892-ycc3csyh	314	17	independent	independent	JJ
cord-270892-ycc3csyh	314	18	of	of	IN
cord-270892-ycc3csyh	314	19	receptor	receptor	NN
cord-270892-ycc3csyh	314	20	grouping	grouping	NN
cord-270892-ycc3csyh	314	21	whereas	whereas	IN
cord-270892-ycc3csyh	314	22	prevention	prevention	NN
cord-270892-ycc3csyh	314	23	of	of	IN
cord-270892-ycc3csyh	314	24	virus	virus	NN
cord-270892-ycc3csyh	314	25	attachment	attachment	NN
cord-270892-ycc3csyh	314	26	was	be	VBD
cord-270892-ycc3csyh	314	27	found	find	VBN
cord-270892-ycc3csyh	314	28	to	to	TO
cord-270892-ycc3csyh	314	29	be	be	VB
cord-270892-ycc3csyh	314	30	an	an	DT
cord-270892-ycc3csyh	314	31	additional	additional	JJ
cord-270892-ycc3csyh	314	32	mode	mode	NN
cord-270892-ycc3csyh	314	33	of	of	IN
cord-270892-ycc3csyh	314	34	action	action	NN
cord-270892-ycc3csyh	314	35	for	for	IN
cord-270892-ycc3csyh	314	36	individual	individual	JJ
cord-270892-ycc3csyh	314	37	viruses	virus	NNS
cord-270892-ycc3csyh	314	38	and/or	and/or	CC
cord-270892-ycc3csyh	314	39	drugs	drug	NNS
cord-270892-ycc3csyh	314	40	.	.	.
cord-270892-ycc3csyh	315	1	Till	till	IN
cord-270892-ycc3csyh	315	2	now	now	RB
cord-270892-ycc3csyh	315	3	,	,	,
cord-270892-ycc3csyh	315	4	various	various	JJ
cord-270892-ycc3csyh	315	5	potent	potent	JJ
cord-270892-ycc3csyh	315	6	compounds	compound	NNS
cord-270892-ycc3csyh	315	7	belonging	belong	VBG
cord-270892-ycc3csyh	315	8	to	to	IN
cord-270892-ycc3csyh	315	9	diverse	diverse	JJ
cord-270892-ycc3csyh	315	10	chemical	chemical	NN
cord-270892-ycc3csyh	315	11	classes	class	NNS
cord-270892-ycc3csyh	315	12	have	have	VBP
cord-270892-ycc3csyh	315	13	been	be	VBN
cord-270892-ycc3csyh	315	14	described	describe	VBN
cord-270892-ycc3csyh	315	15	as	as	IN
cord-270892-ycc3csyh	315	16	uncoating	uncoating	NN
cord-270892-ycc3csyh	315	17	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	315	18	.	.	.
cord-270892-ycc3csyh	316	1	Just	just	RB
cord-270892-ycc3csyh	316	2	to	to	TO
cord-270892-ycc3csyh	316	3	give	give	VB
cord-270892-ycc3csyh	316	4	an	an	DT
cord-270892-ycc3csyh	316	5	impression	impression	NN
cord-270892-ycc3csyh	316	6	of	of	IN
cord-270892-ycc3csyh	316	7	diversity	diversity	NN
cord-270892-ycc3csyh	316	8	,	,	,
cord-270892-ycc3csyh	316	9	the	the	DT
cord-270892-ycc3csyh	316	10	structures	structure	NNS
cord-270892-ycc3csyh	316	11	of	of	IN
cord-270892-ycc3csyh	316	12	disoxaril	disoxaril	NNP
cord-270892-ycc3csyh	316	13	and	and	CC
cord-270892-ycc3csyh	316	14	pleconaril	pleconaril	NNP
cord-270892-ycc3csyh	316	15	,	,	,
cord-270892-ycc3csyh	316	16	12,183	12,183	CD
cord-270892-ycc3csyh	316	17	-	-	SYM
cord-270892-ycc3csyh	316	18	185	185	CD
cord-270892-ycc3csyh	316	19	pirodavir	pirodavir	NNS
cord-270892-ycc3csyh	316	20	and	and	CC
cord-270892-ycc3csyh	316	21	the	the	DT
cord-270892-ycc3csyh	316	22	oxime	oxime	NN
cord-270892-ycc3csyh	316	23	ether	ether	NN
cord-270892-ycc3csyh	316	24	,	,	,
cord-270892-ycc3csyh	316	25	14	14	CD
cord-270892-ycc3csyh	316	26	,	,	,
cord-270892-ycc3csyh	316	27	141	141	CD
cord-270892-ycc3csyh	316	28	,	,	,
cord-270892-ycc3csyh	316	29	142	142	CD
cord-270892-ycc3csyh	316	30	,	,	,
cord-270892-ycc3csyh	316	31	186	186	CD
cord-270892-ycc3csyh	316	32	,	,	,
cord-270892-ycc3csyh	316	33	187	187	CD
cord-270892-ycc3csyh	316	34	the	the	DT
cord-270892-ycc3csyh	316	35	isoxazole	isoxazole	NNP
cord-270892-ycc3csyh	316	36	derivate	derivate	NNP
cord-270892-ycc3csyh	316	37	compound	compound	NNP
cord-270892-ycc3csyh	316	38	,	,	,
cord-270892-ycc3csyh	316	39	19	19	CD
cord-270892-ycc3csyh	316	40	,	,	,
cord-270892-ycc3csyh	316	41	143	143	CD
cord-270892-ycc3csyh	316	42	,	,	,
cord-270892-ycc3csyh	316	43	188	188	CD
cord-270892-ycc3csyh	316	44	the	the	DT
cord-270892-ycc3csyh	316	45	imidazole	imidazole	JJ
cord-270892-ycc3csyh	316	46	derivative	derivative	JJ
cord-270892-ycc3csyh	316	47	SCH	SCH	NNP
cord-270892-ycc3csyh	316	48	38057	38057	CD
cord-270892-ycc3csyh	316	49	,	,	,
cord-270892-ycc3csyh	316	50	[	[	-LRB-
cord-270892-ycc3csyh	316	51	189	189	CD
cord-270892-ycc3csyh	316	52	]	]	-RRB-
cord-270892-ycc3csyh	316	53	[	[	-LRB-
cord-270892-ycc3csyh	316	54	190	190	CD
cord-270892-ycc3csyh	316	55	]	]	-RRB-
cord-270892-ycc3csyh	316	56	[	[	-LRB-
cord-270892-ycc3csyh	316	57	191	191	CD
cord-270892-ycc3csyh	316	58	]	]	-RRB-
cord-270892-ycc3csyh	316	59	the	the	DT
cord-270892-ycc3csyh	316	60	chalcone	chalcone	NN
cord-270892-ycc3csyh	316	61	Ro	Ro	NNP
cord-270892-ycc3csyh	316	62	09	09	CD
cord-270892-ycc3csyh	316	63	-	-	HYPH
cord-270892-ycc3csyh	316	64	0881	0881	CD
cord-270892-ycc3csyh	316	65	,	,	,
cord-270892-ycc3csyh	316	66	192	192	CD
cord-270892-ycc3csyh	316	67	,	,	,
cord-270892-ycc3csyh	316	68	193	193	CD
cord-270892-ycc3csyh	316	69	4	4	CD
cord-270892-ycc3csyh	316	70	0	0	CD
cord-270892-ycc3csyh	316	71	,	,	,
cord-270892-ycc3csyh	316	72	6	6	CD
cord-270892-ycc3csyh	316	73	dichloroflavan	dichloroflavan	NNP
cord-270892-ycc3csyh	316	74	and	and	CC
cord-270892-ycc3csyh	316	75	isoflavan	isoflavan	NNP
cord-270892-ycc3csyh	316	76	,	,	,
cord-270892-ycc3csyh	316	77	137	137	CD
cord-270892-ycc3csyh	316	78	,	,	,
cord-270892-ycc3csyh	316	79	194	194	CD
cord-270892-ycc3csyh	316	80	the	the	DT
cord-270892-ycc3csyh	316	81	pyridine	pyridine	JJ
cord-270892-ycc3csyh	316	82	derivative	derivative	JJ
cord-270892-ycc3csyh	316	83	MDL	MDL	NNP
cord-270892-ycc3csyh	316	84	20	20	CD
cord-270892-ycc3csyh	316	85	,	,	,
cord-270892-ycc3csyh	316	86	957	957	CD
cord-270892-ycc3csyh	316	87	,	,	,
cord-270892-ycc3csyh	316	88	195	195	CD
cord-270892-ycc3csyh	316	89	,	,	,
cord-270892-ycc3csyh	316	90	196	196	CD
cord-270892-ycc3csyh	316	91	and	and	CC
cord-270892-ycc3csyh	316	92	the	the	DT
cord-270892-ycc3csyh	316	93	phenoxybenzene	phenoxybenzene	NNP
cord-270892-ycc3csyh	316	94	MDL-860	MDL-860	NNP
cord-270892-ycc3csyh	316	95	197	197	CD
cord-270892-ycc3csyh	316	96	,	,	,
cord-270892-ycc3csyh	316	97	198	198	CD
cord-270892-ycc3csyh	316	98	that	that	DT
cord-270892-ycc3csyh	316	99	exhibit	exhibit	NN
cord-270892-ycc3csyh	317	1	a	a	DT
cord-270892-ycc3csyh	317	2	potent	potent	JJ
cord-270892-ycc3csyh	317	3	anti	anti	JJ
cord-270892-ycc3csyh	317	4	-	-	JJ
cord-270892-ycc3csyh	317	5	HRV	HRV	NNP
cord-270892-ycc3csyh	317	6	activity	activity	NN
cord-270892-ycc3csyh	317	7	(	(	-LRB-
cord-270892-ycc3csyh	317	8	Table	Table	NNP
cord-270892-ycc3csyh	317	9	II	ii	CD
cord-270892-ycc3csyh	317	10	)	)	-RRB-
cord-270892-ycc3csyh	317	11	are	be	VBP
cord-270892-ycc3csyh	317	12	shown	show	VBN
cord-270892-ycc3csyh	317	13	as	as	IN
cord-270892-ycc3csyh	317	14	examples	example	NNS
cord-270892-ycc3csyh	317	15	in	in	IN
cord-270892-ycc3csyh	317	16	Figure	figure	NN
cord-270892-ycc3csyh	317	17	2	2	CD
cord-270892-ycc3csyh	317	18	.	.	.
cord-270892-ycc3csyh	318	1	They	-PRON-	PRP
cord-270892-ycc3csyh	318	2	inhibit	inhibit	VBP
cord-270892-ycc3csyh	318	3	most	most	JJS
cord-270892-ycc3csyh	318	4	of	of	IN
cord-270892-ycc3csyh	318	5	HRV	HRV	NNP
cord-270892-ycc3csyh	318	6	serotypes	serotype	NNS
cord-270892-ycc3csyh	318	7	and	and	CC
cord-270892-ycc3csyh	318	8	a	a	DT
cord-270892-ycc3csyh	318	9	couple	couple	NN
cord-270892-ycc3csyh	318	10	of	of	IN
cord-270892-ycc3csyh	318	11	them	-PRON-	PRP
cord-270892-ycc3csyh	318	12	also	also	RB
cord-270892-ycc3csyh	318	13	affect	affect	VBP
cord-270892-ycc3csyh	318	14	enteroviruses	enterovirus	NNS
cord-270892-ycc3csyh	318	15	,	,	,
cord-270892-ycc3csyh	318	16	however	however	RB
cord-270892-ycc3csyh	318	17	,	,	,
cord-270892-ycc3csyh	318	18	with	with	IN
cord-270892-ycc3csyh	318	19	varying	vary	VBG
cord-270892-ycc3csyh	318	20	susceptibility	susceptibility	NN
cord-270892-ycc3csyh	318	21	.	.	.
cord-270892-ycc3csyh	319	1	Based	base	VBN
cord-270892-ycc3csyh	319	2	on	on	IN
cord-270892-ycc3csyh	319	3	variability	variability	NN
cord-270892-ycc3csyh	319	4	of	of	IN
cord-270892-ycc3csyh	319	5	susceptibility	susceptibility	NN
cord-270892-ycc3csyh	319	6	to	to	IN
cord-270892-ycc3csyh	319	7	capsid	capsid	NN
cord-270892-ycc3csyh	319	8	-	-	HYPH
cord-270892-ycc3csyh	319	9	binders	binder	NNS
cord-270892-ycc3csyh	319	10	of	of	IN
cord-270892-ycc3csyh	319	11	different	different	JJ
cord-270892-ycc3csyh	319	12	length	length	NN
cord-270892-ycc3csyh	319	13	,	,	,
cord-270892-ycc3csyh	319	14	HRV	HRV	NNP
cord-270892-ycc3csyh	319	15	serotypes	serotype	NNS
cord-270892-ycc3csyh	319	16	were	be	VBD
cord-270892-ycc3csyh	319	17	classified	classify	VBN
cord-270892-ycc3csyh	319	18	into	into	IN
cord-270892-ycc3csyh	319	19	two	two	CD
cord-270892-ycc3csyh	319	20	different	different	JJ
cord-270892-ycc3csyh	319	21	groups	group	NNS
cord-270892-ycc3csyh	319	22	,	,	,
cord-270892-ycc3csyh	319	23	A	A	NNP
cord-270892-ycc3csyh	319	24	and	and	CC
cord-270892-ycc3csyh	319	25	B.	B.	NNP
cord-270892-ycc3csyh	319	26	140	140	CD
cord-270892-ycc3csyh	319	27	Several	several	JJ
cord-270892-ycc3csyh	319	28	of	of	IN
cord-270892-ycc3csyh	319	29	the	the	DT
cord-270892-ycc3csyh	319	30	given	give	VBN
cord-270892-ycc3csyh	319	31	examples	example	NNS
cord-270892-ycc3csyh	319	32	of	of	IN
cord-270892-ycc3csyh	319	33	compounds	compound	NNS
cord-270892-ycc3csyh	319	34	were	be	VBD
cord-270892-ycc3csyh	319	35	also	also	RB
cord-270892-ycc3csyh	319	36	clinically	clinically	RB
cord-270892-ycc3csyh	319	37	tested	test	VBN
cord-270892-ycc3csyh	319	38	.	.	.
cord-270892-ycc3csyh	320	1	Studying	study	VBG
cord-270892-ycc3csyh	320	2	the	the	DT
cord-270892-ycc3csyh	320	3	development	development	NN
cord-270892-ycc3csyh	320	4	of	of	IN
cord-270892-ycc3csyh	320	5	clinically	clinically	RB
cord-270892-ycc3csyh	320	6	effective	effective	JJ
cord-270892-ycc3csyh	320	7	capsid	capsid	NN
cord-270892-ycc3csyh	320	8	-	-	HYPH
cord-270892-ycc3csyh	320	9	binders	binder	NNS
cord-270892-ycc3csyh	320	10	,	,	,
cord-270892-ycc3csyh	320	11	the	the	DT
cord-270892-ycc3csyh	320	12	long	long	JJ
cord-270892-ycc3csyh	320	13	road	road	NN
cord-270892-ycc3csyh	320	14	to	to	IN
cord-270892-ycc3csyh	320	15	the	the	DT
cord-270892-ycc3csyh	320	16	discovery	discovery	NN
cord-270892-ycc3csyh	320	17	of	of	IN
cord-270892-ycc3csyh	320	18	a	a	DT
cord-270892-ycc3csyh	320	19	clinically	clinically	RB
cord-270892-ycc3csyh	320	20	effective	effective	JJ
cord-270892-ycc3csyh	320	21	anti	anti	JJ
cord-270892-ycc3csyh	320	22	-	-	JJ
cord-270892-ycc3csyh	320	23	HRV	HRV	NNP
cord-270892-ycc3csyh	320	24	drug	drug	NN
cord-270892-ycc3csyh	320	25	becomes	become	VBZ
cord-270892-ycc3csyh	320	26	apparent	apparent	JJ
cord-270892-ycc3csyh	320	27	.	.	.
cord-270892-ycc3csyh	321	1	One	one	CD
cord-270892-ycc3csyh	321	2	well	well	RB
cord-270892-ycc3csyh	321	3	-	-	HYPH
cord-270892-ycc3csyh	321	4	described	describe	VBN
cord-270892-ycc3csyh	321	5	example	example	NN
cord-270892-ycc3csyh	321	6	represents	represent	VBZ
cord-270892-ycc3csyh	321	7	the	the	DT
cord-270892-ycc3csyh	321	8	discovery	discovery	NN
cord-270892-ycc3csyh	321	9	and	and	CC
cord-270892-ycc3csyh	321	10	optimization	optimization	NN
cord-270892-ycc3csyh	321	11	of	of	IN
cord-270892-ycc3csyh	321	12	capsid	capsid	NN
cord-270892-ycc3csyh	321	13	-	-	HYPH
cord-270892-ycc3csyh	321	14	binders	binder	NNS
cord-270892-ycc3csyh	321	15	from	from	IN
cord-270892-ycc3csyh	321	16	Sterling	Sterling	NNP
cord-270892-ycc3csyh	321	17	Winthrop	Winthrop	NNP
cord-270892-ycc3csyh	321	18	Pharmaceutical	Pharmaceutical	NNP
cord-270892-ycc3csyh	321	19	group	group	NN
cord-270892-ycc3csyh	321	20	,	,	,
cord-270892-ycc3csyh	321	21	the	the	DT
cord-270892-ycc3csyh	321	22	so	so	RB
cord-270892-ycc3csyh	321	23	-	-	HYPH
cord-270892-ycc3csyh	321	24	called	call	VBN
cord-270892-ycc3csyh	321	25	WIN	WIN	NNP
cord-270892-ycc3csyh	321	26	compounds	compound	NNS
cord-270892-ycc3csyh	321	27	.	.	.
cord-270892-ycc3csyh	322	1	174	174	CD
cord-270892-ycc3csyh	323	1	First	first	JJ
cord-270892-ycc3csyh	323	2	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	323	3	originated	originate	VBD
cord-270892-ycc3csyh	323	4	from	from	IN
cord-270892-ycc3csyh	323	5	juvenile	juvenile	JJ
cord-270892-ycc3csyh	323	6	hormone	hormone	NN
cord-270892-ycc3csyh	323	7	mimetics	mimetic	NNS
cord-270892-ycc3csyh	323	8	that	that	WDT
cord-270892-ycc3csyh	323	9	demonstrated	demonstrate	VBD
cord-270892-ycc3csyh	323	10	some	some	DT
cord-270892-ycc3csyh	323	11	activity	activity	NN
cord-270892-ycc3csyh	323	12	against	against	IN
cord-270892-ycc3csyh	323	13	HRV-1A.	HRV-1A.	NNP
cord-270892-ycc3csyh	323	14	Determination	determination	NN
cord-270892-ycc3csyh	323	15	of	of	IN
cord-270892-ycc3csyh	323	16	the	the	DT
cord-270892-ycc3csyh	323	17	X	x	NN
cord-270892-ycc3csyh	323	18	-	-	NN
cord-270892-ycc3csyh	323	19	ray	ray	JJ
cord-270892-ycc3csyh	323	20	structure	structure	NN
cord-270892-ycc3csyh	323	21	of	of	IN
cord-270892-ycc3csyh	323	22	HRV-14	HRV-14	NNP
cord-270892-ycc3csyh	323	23	helped	help	VBD
cord-270892-ycc3csyh	323	24	to	to	TO
cord-270892-ycc3csyh	323	25	understand	understand	VB
cord-270892-ycc3csyh	323	26	the	the	DT
cord-270892-ycc3csyh	323	27	compounds	compound	NNS
cord-270892-ycc3csyh	323	28	'	'	POS
cord-270892-ycc3csyh	323	29	binding	bind	VBG
cord-270892-ycc3csyh	323	30	sites	site	NNS
cord-270892-ycc3csyh	323	31	at	at	IN
cord-270892-ycc3csyh	323	32	the	the	DT
cord-270892-ycc3csyh	323	33	virus	virus	NN
cord-270892-ycc3csyh	323	34	capsid	capsid	NN
cord-270892-ycc3csyh	323	35	.	.	.
cord-270892-ycc3csyh	324	1	103	103	CD
cord-270892-ycc3csyh	324	2	Results	result	NNS
cord-270892-ycc3csyh	324	3	from	from	IN
cord-270892-ycc3csyh	324	4	subsequent	subsequent	JJ
cord-270892-ycc3csyh	324	5	X	x	NN
cord-270892-ycc3csyh	324	6	-	-	NN
cord-270892-ycc3csyh	324	7	ray	ray	JJ
cord-270892-ycc3csyh	324	8	studies	study	NNS
cord-270892-ycc3csyh	324	9	of	of	IN
cord-270892-ycc3csyh	324	10	HRV	HRV	NNP
cord-270892-ycc3csyh	324	11	-	-	HYPH
cord-270892-ycc3csyh	324	12	WIN	WIN	NNP
cord-270892-ycc3csyh	324	13	compound	compound	NN
cord-270892-ycc3csyh	324	14	complexes	complex	NNS
cord-270892-ycc3csyh	324	15	revealed	reveal	VBD
cord-270892-ycc3csyh	324	16	the	the	DT
cord-270892-ycc3csyh	324	17	location	location	NN
cord-270892-ycc3csyh	324	18	and	and	CC
cord-270892-ycc3csyh	324	19	nature	nature	NN
cord-270892-ycc3csyh	324	20	of	of	IN
cord-270892-ycc3csyh	324	21	binding	bind	VBG
cord-270892-ycc3csyh	324	22	sites	site	NNS
cord-270892-ycc3csyh	324	23	and	and	CC
cord-270892-ycc3csyh	324	24	provided	provide	VBD
cord-270892-ycc3csyh	324	25	information	information	NN
cord-270892-ycc3csyh	324	26	concerning	concern	VBG
cord-270892-ycc3csyh	324	27	interactions	interaction	NNS
cord-270892-ycc3csyh	324	28	within	within	IN
cord-270892-ycc3csyh	324	29	these	these	DT
cord-270892-ycc3csyh	324	30	sites	site	NNS
cord-270892-ycc3csyh	324	31	.	.	.
cord-270892-ycc3csyh	325	1	175	175	CD
cord-270892-ycc3csyh	325	2	,	,	,
cord-270892-ycc3csyh	325	3	179	179	CD
cord-270892-ycc3csyh	325	4	,	,	,
cord-270892-ycc3csyh	325	5	180	180	CD
cord-270892-ycc3csyh	326	1	This	this	DT
cord-270892-ycc3csyh	326	2	knowledge	knowledge	NN
cord-270892-ycc3csyh	326	3	was	be	VBD
cord-270892-ycc3csyh	326	4	used	use	VBN
cord-270892-ycc3csyh	326	5	for	for	IN
cord-270892-ycc3csyh	326	6	optimization	optimization	NN
cord-270892-ycc3csyh	326	7	and	and	CC
cord-270892-ycc3csyh	326	8	design	design	NN
cord-270892-ycc3csyh	326	9	of	of	IN
cord-270892-ycc3csyh	326	10	new	new	JJ
cord-270892-ycc3csyh	326	11	compounds	compound	NNS
cord-270892-ycc3csyh	326	12	.	.	.
cord-270892-ycc3csyh	327	1	199	199	CD
cord-270892-ycc3csyh	328	1	Optimized	optimize	VBN
cord-270892-ycc3csyh	328	2	WIN	WIN	NNP
cord-270892-ycc3csyh	328	3	compounds	compound	NNS
cord-270892-ycc3csyh	328	4	,	,	,
cord-270892-ycc3csyh	328	5	for	for	IN
cord-270892-ycc3csyh	328	6	example	example	NN
cord-270892-ycc3csyh	328	7	disoxaril	disoxaril	NNP
cord-270892-ycc3csyh	328	8	and	and	CC
cord-270892-ycc3csyh	328	9	pleconaril	pleconaril	NNP
cord-270892-ycc3csyh	328	10	(	(	-LRB-
cord-270892-ycc3csyh	328	11	Fig	Fig	NNP
cord-270892-ycc3csyh	328	12	.	.	NNP
cord-270892-ycc3csyh	328	13	2	2	CD
cord-270892-ycc3csyh	328	14	)	)	-RRB-
cord-270892-ycc3csyh	328	15	,	,	,
cord-270892-ycc3csyh	328	16	consist	consist	VBP
cord-270892-ycc3csyh	328	17	of	of	IN
cord-270892-ycc3csyh	328	18	a	a	DT
cord-270892-ycc3csyh	328	19	methylisoxazol	methylisoxazol	JJ
cord-270892-ycc3csyh	328	20	ring	ring	NN
cord-270892-ycc3csyh	328	21	,	,	,
cord-270892-ycc3csyh	328	22	a	a	DT
cord-270892-ycc3csyh	328	23	substituted	substitute	VBN
cord-270892-ycc3csyh	328	24	phenoxy	phenoxy	NNP
cord-270892-ycc3csyh	328	25	group	group	NN
cord-270892-ycc3csyh	328	26	,	,	,
cord-270892-ycc3csyh	328	27	and	and	CC
cord-270892-ycc3csyh	328	28	a	a	DT
cord-270892-ycc3csyh	328	29	five	five	CD
cord-270892-ycc3csyh	328	30	-	-	HYPH
cord-270892-ycc3csyh	328	31	membered	membered	JJ
cord-270892-ycc3csyh	328	32	heteroatom	heteroatom	NN
cord-270892-ycc3csyh	328	33	ring	ring	NN
cord-270892-ycc3csyh	328	34	and	and	CC
cord-270892-ycc3csyh	328	35	inhibit	inhibit	VB
cord-270892-ycc3csyh	328	36	a	a	DT
cord-270892-ycc3csyh	328	37	broad	broad	JJ
cord-270892-ycc3csyh	328	38	spectrum	spectrum	NN
cord-270892-ycc3csyh	328	39	of	of	IN
cord-270892-ycc3csyh	328	40	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	328	41	and	and	CC
cord-270892-ycc3csyh	328	42	enteroviruses	enteroviruses	NNP
cord-270892-ycc3csyh	328	43	(	(	-LRB-
cord-270892-ycc3csyh	328	44	Table	Table	NNP
cord-270892-ycc3csyh	328	45	II	II	NNP
cord-270892-ycc3csyh	328	46	)	)	-RRB-
cord-270892-ycc3csyh	328	47	.	.	.
cord-270892-ycc3csyh	329	1	12	12	CD
cord-270892-ycc3csyh	329	2	,	,	,
cord-270892-ycc3csyh	329	3	[	[	-LRB-
cord-270892-ycc3csyh	329	4	183	183	CD
cord-270892-ycc3csyh	329	5	]	]	-RRB-
cord-270892-ycc3csyh	329	6	[	[	-LRB-
cord-270892-ycc3csyh	329	7	184	184	CD
cord-270892-ycc3csyh	329	8	]	]	-RRB-
cord-270892-ycc3csyh	329	9	[	[	-LRB-
cord-270892-ycc3csyh	329	10	185	185	CD
cord-270892-ycc3csyh	329	11	]	]	-RRB-
cord-270892-ycc3csyh	330	1	In	in	IN
cord-270892-ycc3csyh	330	2	1985	1985	CD
cord-270892-ycc3csyh	330	3	,	,	,
cord-270892-ycc3csyh	330	4	the	the	DT
cord-270892-ycc3csyh	330	5	first	first	JJ
cord-270892-ycc3csyh	330	6	broad	broad	JJ
cord-270892-ycc3csyh	330	7	-	-	HYPH
cord-270892-ycc3csyh	330	8	spectrum	spectrum	NN
cord-270892-ycc3csyh	330	9	WIN	win	NN
cord-270892-ycc3csyh	330	10	compound	compound	NN
cord-270892-ycc3csyh	330	11	disoxaril	disoxaril	NN
cord-270892-ycc3csyh	330	12	(	(	-LRB-
cord-270892-ycc3csyh	330	13	Win	Win	NNP
cord-270892-ycc3csyh	330	14	51711	51711	CD
cord-270892-ycc3csyh	330	15	)	)	-RRB-
cord-270892-ycc3csyh	330	16	was	be	VBD
cord-270892-ycc3csyh	330	17	tested	test	VBN
cord-270892-ycc3csyh	330	18	in	in	IN
cord-270892-ycc3csyh	330	19	clinical	clinical	JJ
cord-270892-ycc3csyh	330	20	trials	trial	NNS
cord-270892-ycc3csyh	330	21	.	.	.
cord-270892-ycc3csyh	331	1	139	139	CD
cord-270892-ycc3csyh	332	1	The	the	DT
cord-270892-ycc3csyh	332	2	development	development	NN
cord-270892-ycc3csyh	332	3	of	of	IN
cord-270892-ycc3csyh	332	4	crystallurea	crystallurea	NN
cord-270892-ycc3csyh	332	5	in	in	IN
cord-270892-ycc3csyh	332	6	human	human	JJ
cord-270892-ycc3csyh	332	7	volunteers	volunteer	NNS
cord-270892-ycc3csyh	332	8	treated	treat	VBN
cord-270892-ycc3csyh	332	9	with	with	IN
cord-270892-ycc3csyh	332	10	high	high	JJ
cord-270892-ycc3csyh	332	11	doses	dose	NNS
cord-270892-ycc3csyh	332	12	as	as	RB
cord-270892-ycc3csyh	332	13	well	well	RB
cord-270892-ycc3csyh	332	14	as	as	IN
cord-270892-ycc3csyh	332	15	its	-PRON-	PRP$
cord-270892-ycc3csyh	332	16	low	low	JJ
cord-270892-ycc3csyh	332	17	bioavailability	bioavailability	NN
cord-270892-ycc3csyh	332	18	(	(	-LRB-
cord-270892-ycc3csyh	332	19	15	15	CD
cord-270892-ycc3csyh	332	20	%	%	NN
cord-270892-ycc3csyh	332	21	)	)	-RRB-
cord-270892-ycc3csyh	332	22	prohibited	prohibit	VBN
cord-270892-ycc3csyh	332	23	subsequent	subsequent	JJ
cord-270892-ycc3csyh	332	24	development	development	NN
cord-270892-ycc3csyh	332	25	.	.	.
cord-270892-ycc3csyh	333	1	Thereafter	thereafter	RB
cord-270892-ycc3csyh	333	2	,	,	,
cord-270892-ycc3csyh	333	3	results	result	NNS
cord-270892-ycc3csyh	333	4	from	from	IN
cord-270892-ycc3csyh	333	5	SAR	SAR	NNP
cord-270892-ycc3csyh	333	6	and	and	CC
cord-270892-ycc3csyh	333	7	QSAR	QSAR	NNP
cord-270892-ycc3csyh	333	8	analysis	analysis	NN
cord-270892-ycc3csyh	333	9	were	be	VBD
cord-270892-ycc3csyh	333	10	used	use	VBN
cord-270892-ycc3csyh	333	11	to	to	TO
cord-270892-ycc3csyh	333	12	further	further	RB
cord-270892-ycc3csyh	333	13	enhance	enhance	VB
cord-270892-ycc3csyh	333	14	the	the	DT
cord-270892-ycc3csyh	333	15	potency	potency	NN
cord-270892-ycc3csyh	333	16	and	and	CC
cord-270892-ycc3csyh	333	17	spectrum	spectrum	NN
cord-270892-ycc3csyh	333	18	of	of	IN
cord-270892-ycc3csyh	333	19	activity	activity	NN
cord-270892-ycc3csyh	333	20	.	.	.
cord-270892-ycc3csyh	334	1	In	in	IN
cord-270892-ycc3csyh	334	2	1992	1992	CD
cord-270892-ycc3csyh	334	3	,	,	,
cord-270892-ycc3csyh	334	4	another	another	DT
cord-270892-ycc3csyh	334	5	compound	compound	NN
cord-270892-ycc3csyh	334	6	,	,	,
cord-270892-ycc3csyh	334	7	WIN	win	NN
cord-270892-ycc3csyh	334	8	54954	54954	CD
cord-270892-ycc3csyh	334	9	,	,	,
cord-270892-ycc3csyh	334	10	was	be	VBD
cord-270892-ycc3csyh	334	11	clinically	clinically	RB
cord-270892-ycc3csyh	334	12	tested	test	VBN
cord-270892-ycc3csyh	334	13	.	.	.
cord-270892-ycc3csyh	335	1	It	-PRON-	PRP
cord-270892-ycc3csyh	335	2	was	be	VBD
cord-270892-ycc3csyh	335	3	not	not	RB
cord-270892-ycc3csyh	335	4	effective	effective	JJ
cord-270892-ycc3csyh	335	5	in	in	IN
cord-270892-ycc3csyh	335	6	humans	human	NNS
cord-270892-ycc3csyh	335	7	infected	infect	VBN
cord-270892-ycc3csyh	335	8	with	with	IN
cord-270892-ycc3csyh	335	9	HRV-23	HRV-23	NNP
cord-270892-ycc3csyh	335	10	and	and	CC
cord-270892-ycc3csyh	335	11	HRV-29	HRV-29	NNP
cord-270892-ycc3csyh	335	12	.	.	.
cord-270892-ycc3csyh	336	1	153	153	CD
cord-270892-ycc3csyh	337	1	Moreover	moreover	RB
cord-270892-ycc3csyh	337	2	,	,	,
cord-270892-ycc3csyh	337	3	it	-PRON-	PRP
cord-270892-ycc3csyh	337	4	was	be	VBD
cord-270892-ycc3csyh	337	5	rapidly	rapidly	RB
cord-270892-ycc3csyh	337	6	metabolized	metabolize	VBN
cord-270892-ycc3csyh	337	7	and	and	CC
cord-270892-ycc3csyh	337	8	induced	induce	VBN
cord-270892-ycc3csyh	337	9	a	a	DT
cord-270892-ycc3csyh	337	10	reversible	reversible	JJ
cord-270892-ycc3csyh	337	11	hepatitis	hepatitis	NN
cord-270892-ycc3csyh	337	12	.	.	.
cord-270892-ycc3csyh	338	1	Consequently	consequently	RB
cord-270892-ycc3csyh	338	2	,	,	,
cord-270892-ycc3csyh	338	3	the	the	DT
cord-270892-ycc3csyh	338	4	further	further	JJ
cord-270892-ycc3csyh	338	5	clinical	clinical	JJ
cord-270892-ycc3csyh	338	6	development	development	NN
cord-270892-ycc3csyh	338	7	was	be	VBD
cord-270892-ycc3csyh	338	8	stopped	stop	VBN
cord-270892-ycc3csyh	338	9	.	.	.
cord-270892-ycc3csyh	339	1	The	the	DT
cord-270892-ycc3csyh	339	2	better	well	JJR
cord-270892-ycc3csyh	339	3	understanding	understanding	NN
cord-270892-ycc3csyh	339	4	of	of	IN
cord-270892-ycc3csyh	339	5	pharmacokinetic	pharmacokinetic	JJ
cord-270892-ycc3csyh	339	6	properties	property	NNS
cord-270892-ycc3csyh	339	7	of	of	IN
cord-270892-ycc3csyh	339	8	capsid	capsid	NN
cord-270892-ycc3csyh	339	9	binders	binder	NNS
cord-270892-ycc3csyh	339	10	and	and	CC
cord-270892-ycc3csyh	339	11	synthetic	synthetic	JJ
cord-270892-ycc3csyh	339	12	chemistry	chemistry	NN
cord-270892-ycc3csyh	339	13	efforts	effort	NNS
cord-270892-ycc3csyh	339	14	led	lead	VBD
cord-270892-ycc3csyh	339	15	to	to	IN
cord-270892-ycc3csyh	339	16	the	the	DT
cord-270892-ycc3csyh	339	17	discovery	discovery	NN
cord-270892-ycc3csyh	339	18	of	of	IN
cord-270892-ycc3csyh	339	19	pleconaril	pleconaril	NNP
cord-270892-ycc3csyh	339	20	,	,	,
cord-270892-ycc3csyh	339	21	an	an	DT
cord-270892-ycc3csyh	339	22	orally	orally	RB
cord-270892-ycc3csyh	339	23	bioavailable	bioavailable	JJ
cord-270892-ycc3csyh	339	24	,	,	,
cord-270892-ycc3csyh	339	25	welltolerated	welltolerated	JJ
cord-270892-ycc3csyh	339	26	capsid	capsid	NN
cord-270892-ycc3csyh	339	27	-	-	HYPH
cord-270892-ycc3csyh	339	28	binder	binder	NN
cord-270892-ycc3csyh	339	29	that	that	WDT
cord-270892-ycc3csyh	339	30	inhibits	inhibit	VBZ
cord-270892-ycc3csyh	339	31	most	most	JJS
cord-270892-ycc3csyh	339	32	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	339	33	as	as	RB
cord-270892-ycc3csyh	339	34	well	well	RB
cord-270892-ycc3csyh	339	35	as	as	IN
cord-270892-ycc3csyh	339	36	various	various	JJ
cord-270892-ycc3csyh	339	37	enterovirus	enterovirus	NN
cord-270892-ycc3csyh	339	38	serotypes	serotype	NNS
cord-270892-ycc3csyh	339	39	.	.	.
cord-270892-ycc3csyh	340	1	12	12	CD
cord-270892-ycc3csyh	340	2	,	,	,
cord-270892-ycc3csyh	340	3	[	[	-LRB-
cord-270892-ycc3csyh	340	4	183	183	CD
cord-270892-ycc3csyh	340	5	]	]	-RRB-
cord-270892-ycc3csyh	340	6	[	[	-LRB-
cord-270892-ycc3csyh	340	7	184	184	CD
cord-270892-ycc3csyh	340	8	]	]	-RRB-
cord-270892-ycc3csyh	341	1	[	[	-LRB-
cord-270892-ycc3csyh	341	2	185	185	CD
cord-270892-ycc3csyh	341	3	]	]	-RRB-
cord-270892-ycc3csyh	342	1	In	in	IN
cord-270892-ycc3csyh	342	2	2000	2000	CD
cord-270892-ycc3csyh	342	3	,	,	,
cord-270892-ycc3csyh	342	4	Schiff	Schiff	NNP
cord-270892-ycc3csyh	342	5	et	et	NNP
cord-270892-ycc3csyh	342	6	al	al	NNP
cord-270892-ycc3csyh	342	7	.	.	.
cord-270892-ycc3csyh	343	1	published	publish	VBD
cord-270892-ycc3csyh	343	2	the	the	DT
cord-270892-ycc3csyh	343	3	efficacy	efficacy	NN
cord-270892-ycc3csyh	343	4	of	of	IN
cord-270892-ycc3csyh	343	5	pleconaril	pleconaril	NNP
cord-270892-ycc3csyh	343	6	in	in	IN
cord-270892-ycc3csyh	343	7	an	an	DT
cord-270892-ycc3csyh	343	8	experimentally	experimentally	RB
cord-270892-ycc3csyh	343	9	induced	induce	VBN
cord-270892-ycc3csyh	343	10	coxsackievirus	coxsackievirus	NN
cord-270892-ycc3csyh	343	11	A	a	DT
cord-270892-ycc3csyh	343	12	infection	infection	NN
cord-270892-ycc3csyh	343	13	in	in	IN
cord-270892-ycc3csyh	343	14	humans	human	NNS
cord-270892-ycc3csyh	343	15	.	.	.
cord-270892-ycc3csyh	344	1	200	200	CD
cord-270892-ycc3csyh	345	1	In	in	IN
cord-270892-ycc3csyh	345	2	phase	phase	NN
cord-270892-ycc3csyh	345	3	II	ii	CD
cord-270892-ycc3csyh	345	4	placebo	placebo	NN
cord-270892-ycc3csyh	345	5	-	-	HYPH
cord-270892-ycc3csyh	345	6	controlled	control	VBN
cord-270892-ycc3csyh	345	7	,	,	,
cord-270892-ycc3csyh	345	8	natural	natural	JJ
cord-270892-ycc3csyh	345	9	cold	cold	JJ
cord-270892-ycc3csyh	345	10	trials	trial	NNS
cord-270892-ycc3csyh	345	11	,	,	,
cord-270892-ycc3csyh	345	12	the	the	DT
cord-270892-ycc3csyh	345	13	drug	drug	NN
cord-270892-ycc3csyh	345	14	produced	produce	VBD
cord-270892-ycc3csyh	345	15	a	a	DT
cord-270892-ycc3csyh	345	16	moderate	moderate	JJ
cord-270892-ycc3csyh	345	17	reduction	reduction	NN
cord-270892-ycc3csyh	345	18	of	of	IN
cord-270892-ycc3csyh	345	19	1	1	CD
cord-270892-ycc3csyh	345	20	-	-	SYM
cord-270892-ycc3csyh	345	21	1.5	1.5	CD
cord-270892-ycc3csyh	345	22	day	day	NN
cord-270892-ycc3csyh	345	23	in	in	IN
cord-270892-ycc3csyh	345	24	the	the	DT
cord-270892-ycc3csyh	345	25	medium	medium	JJ
cord-270892-ycc3csyh	345	26	time	time	NN
cord-270892-ycc3csyh	345	27	to	to	IN
cord-270892-ycc3csyh	345	28	elevation	elevation	NN
cord-270892-ycc3csyh	345	29	of	of	IN
cord-270892-ycc3csyh	345	30	illness	illness	NN
cord-270892-ycc3csyh	345	31	compared	compare	VBN
cord-270892-ycc3csyh	345	32	with	with	IN
cord-270892-ycc3csyh	345	33	placebo	placebo	NN
cord-270892-ycc3csyh	345	34	.	.	.
cord-270892-ycc3csyh	346	1	201	201	CD
cord-270892-ycc3csyh	347	1	These	these	DT
cord-270892-ycc3csyh	347	2	results	result	NNS
cord-270892-ycc3csyh	347	3	were	be	VBD
cord-270892-ycc3csyh	347	4	confirmed	confirm	VBN
cord-270892-ycc3csyh	347	5	in	in	IN
cord-270892-ycc3csyh	347	6	two	two	CD
cord-270892-ycc3csyh	347	7	subsequent	subsequent	JJ
cord-270892-ycc3csyh	347	8	pivotal	pivotal	JJ
cord-270892-ycc3csyh	347	9	studies	study	NNS
cord-270892-ycc3csyh	347	10	.	.	.
cord-270892-ycc3csyh	348	1	202	202	CD
cord-270892-ycc3csyh	349	1	Besides	besides	IN
cord-270892-ycc3csyh	349	2	the	the	DT
cord-270892-ycc3csyh	349	3	moderate	moderate	JJ
cord-270892-ycc3csyh	349	4	clinical	clinical	JJ
cord-270892-ycc3csyh	349	5	efficacy	efficacy	NN
cord-270892-ycc3csyh	349	6	,	,	,
cord-270892-ycc3csyh	349	7	these	these	DT
cord-270892-ycc3csyh	349	8	studies	study	NNS
cord-270892-ycc3csyh	349	9	revealed	reveal	VBD
cord-270892-ycc3csyh	349	10	that	that	IN
cord-270892-ycc3csyh	349	11	13	13	CD
cord-270892-ycc3csyh	349	12	%	%	NN
cord-270892-ycc3csyh	349	13	of	of	IN
cord-270892-ycc3csyh	349	14	baseline	baseline	JJ
cord-270892-ycc3csyh	349	15	isolates	isolate	NNS
cord-270892-ycc3csyh	349	16	were	be	VBD
cord-270892-ycc3csyh	349	17	not	not	RB
cord-270892-ycc3csyh	349	18	susceptible	susceptible	JJ
cord-270892-ycc3csyh	349	19	to	to	IN
cord-270892-ycc3csyh	349	20	pleconaril	pleconaril	NN
cord-270892-ycc3csyh	349	21	and	and	CC
cord-270892-ycc3csyh	349	22	11	11	CD
cord-270892-ycc3csyh	349	23	%	%	NN
cord-270892-ycc3csyh	349	24	developed	develop	VBD
cord-270892-ycc3csyh	349	25	reduced	reduced	JJ
cord-270892-ycc3csyh	349	26	susceptibility	susceptibility	NN
cord-270892-ycc3csyh	349	27	(	(	-LRB-
cord-270892-ycc3csyh	349	28	defined	define	VBN
cord-270892-ycc3csyh	349	29	as	as	IN
cord-270892-ycc3csyh	349	30	10-fold	10-fold	JJ
cord-270892-ycc3csyh	349	31	increase	increase	NN
cord-270892-ycc3csyh	349	32	in	in	IN
cord-270892-ycc3csyh	349	33	baseline	baseline	JJ
cord-270892-ycc3csyh	349	34	value	value	NN
cord-270892-ycc3csyh	349	35	)	)	-RRB-
cord-270892-ycc3csyh	349	36	.	.	.
cord-270892-ycc3csyh	350	1	In	in	IN
cord-270892-ycc3csyh	350	2	a	a	DT
cord-270892-ycc3csyh	350	3	subsequent	subsequent	JJ
cord-270892-ycc3csyh	350	4	study	study	NN
cord-270892-ycc3csyh	350	5	the	the	DT
cord-270892-ycc3csyh	350	6	relationship	relationship	NN
cord-270892-ycc3csyh	350	7	of	of	IN
cord-270892-ycc3csyh	350	8	pleconaril	pleconaril	NNP
cord-270892-ycc3csyh	350	9	susceptibility	susceptibility	NN
cord-270892-ycc3csyh	350	10	and	and	CC
cord-270892-ycc3csyh	350	11	clinical	clinical	JJ
cord-270892-ycc3csyh	350	12	outcomes	outcome	NNS
cord-270892-ycc3csyh	350	13	in	in	IN
cord-270892-ycc3csyh	350	14	the	the	DT
cord-270892-ycc3csyh	350	15	treatment	treatment	NN
cord-270892-ycc3csyh	350	16	of	of	IN
cord-270892-ycc3csyh	350	17	common	common	JJ
cord-270892-ycc3csyh	350	18	cold	cold	NN
cord-270892-ycc3csyh	350	19	caused	cause	VBN
cord-270892-ycc3csyh	350	20	by	by	IN
cord-270892-ycc3csyh	350	21	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	350	22	was	be	VBD
cord-270892-ycc3csyh	350	23	demonstrated	demonstrate	VBN
cord-270892-ycc3csyh	350	24	.	.	.
cord-270892-ycc3csyh	351	1	203	203	CD
cord-270892-ycc3csyh	352	1	Based	base	VBN
cord-270892-ycc3csyh	352	2	on	on	IN
cord-270892-ycc3csyh	352	3	drug	drug	NN
cord-270892-ycc3csyh	352	4	interaction	interaction	NN
cord-270892-ycc3csyh	352	5	,	,	,
cord-270892-ycc3csyh	352	6	marginal	marginal	JJ
cord-270892-ycc3csyh	352	7	treatment	treatment	NN
cord-270892-ycc3csyh	352	8	effect	effect	NN
cord-270892-ycc3csyh	352	9	,	,	,
cord-270892-ycc3csyh	352	10	and	and	CC
cord-270892-ycc3csyh	352	11	possibility	possibility	NN
cord-270892-ycc3csyh	352	12	of	of	IN
cord-270892-ycc3csyh	352	13	transmission	transmission	NN
cord-270892-ycc3csyh	352	14	of	of	IN
cord-270892-ycc3csyh	352	15	resistant	resistant	JJ
cord-270892-ycc3csyh	352	16	viruses	virus	NNS
cord-270892-ycc3csyh	352	17	,	,	,
cord-270892-ycc3csyh	352	18	the	the	DT
cord-270892-ycc3csyh	352	19	FDA	FDA	NNP
cord-270892-ycc3csyh	352	20	did	do	VBD
cord-270892-ycc3csyh	352	21	not	not	RB
cord-270892-ycc3csyh	352	22	approve	approve	VB
cord-270892-ycc3csyh	352	23	the	the	DT
cord-270892-ycc3csyh	352	24	applied	apply	VBN
cord-270892-ycc3csyh	352	25	oral	oral	JJ
cord-270892-ycc3csyh	352	26	administration	administration	NNP
cord-270892-ycc3csyh	352	27	of	of	IN
cord-270892-ycc3csyh	352	28	pleconaril	pleconaril	NNP
cord-270892-ycc3csyh	352	29	for	for	IN
cord-270892-ycc3csyh	352	30	the	the	DT
cord-270892-ycc3csyh	352	31	treatment	treatment	NN
cord-270892-ycc3csyh	352	32	of	of	IN
cord-270892-ycc3csyh	352	33	common	common	JJ
cord-270892-ycc3csyh	352	34	cold	cold	NN
cord-270892-ycc3csyh	352	35	.	.	.
cord-270892-ycc3csyh	353	1	The	the	DT
cord-270892-ycc3csyh	353	2	molecular	molecular	JJ
cord-270892-ycc3csyh	353	3	mechanism	mechanism	NN
cord-270892-ycc3csyh	353	4	of	of	IN
cord-270892-ycc3csyh	353	5	drug	drug	NN
cord-270892-ycc3csyh	353	6	interaction	interaction	NN
cord-270892-ycc3csyh	353	7	of	of	IN
cord-270892-ycc3csyh	353	8	orally	orally	RB
cord-270892-ycc3csyh	353	9	given	give	VBN
cord-270892-ycc3csyh	353	10	pleconaril	pleconaril	NN
cord-270892-ycc3csyh	353	11	was	be	VBD
cord-270892-ycc3csyh	353	12	shown	show	VBN
cord-270892-ycc3csyh	353	13	to	to	TO
cord-270892-ycc3csyh	353	14	be	be	VB
cord-270892-ycc3csyh	353	15	based	base	VBN
cord-270892-ycc3csyh	353	16	on	on	IN
cord-270892-ycc3csyh	353	17	hepatic	hepatic	JJ
cord-270892-ycc3csyh	353	18	cytochrome	cytochrome	NN
cord-270892-ycc3csyh	353	19	P450	P450	NNP
cord-270892-ycc3csyh	353	20	3A	3a	CD
cord-270892-ycc3csyh	353	21	activation	activation	NN
cord-270892-ycc3csyh	353	22	.	.	.
cord-270892-ycc3csyh	354	1	204	204	CD
cord-270892-ycc3csyh	355	1	To	to	TO
cord-270892-ycc3csyh	355	2	reduce	reduce	VB
cord-270892-ycc3csyh	355	3	adverse	adverse	JJ
cord-270892-ycc3csyh	355	4	effects	effect	NNS
cord-270892-ycc3csyh	355	5	,	,	,
cord-270892-ycc3csyh	355	6	Shering	Shering	NNP
cord-270892-ycc3csyh	355	7	-	-	HYPH
cord-270892-ycc3csyh	355	8	Plough	Plough	NNP
cord-270892-ycc3csyh	355	9	under	under	IN
cord-270892-ycc3csyh	355	10	license	license	NN
cord-270892-ycc3csyh	355	11	of	of	IN
cord-270892-ycc3csyh	355	12	ViroPharma	ViroPharma	NNP
cord-270892-ycc3csyh	355	13	completed	complete	VBD
cord-270892-ycc3csyh	355	14	a	a	DT
cord-270892-ycc3csyh	355	15	phase	phase	NN
cord-270892-ycc3csyh	355	16	II	ii	CD
cord-270892-ycc3csyh	355	17	clinical	clinical	JJ
cord-270892-ycc3csyh	355	18	trial	trial	NN
cord-270892-ycc3csyh	355	19	with	with	IN
cord-270892-ycc3csyh	355	20	an	an	DT
cord-270892-ycc3csyh	355	21	intranasal	intranasal	NN
cord-270892-ycc3csyh	355	22	formulation	formulation	NN
cord-270892-ycc3csyh	355	23	of	of	IN
cord-270892-ycc3csyh	355	24	pleconaril	pleconaril	NNP
cord-270892-ycc3csyh	355	25	for	for	IN
cord-270892-ycc3csyh	355	26	the	the	DT
cord-270892-ycc3csyh	355	27	potential	potential	JJ
cord-270892-ycc3csyh	355	28	treatment	treatment	NN
cord-270892-ycc3csyh	355	29	of	of	IN
cord-270892-ycc3csyh	355	30	common	common	JJ
cord-270892-ycc3csyh	355	31	cold	cold	NN
cord-270892-ycc3csyh	355	32	in	in	IN
cord-270892-ycc3csyh	355	33	high	high	JJ
cord-270892-ycc3csyh	355	34	-	-	HYPH
cord-270892-ycc3csyh	355	35	risk	risk	NN
cord-270892-ycc3csyh	355	36	populations	population	NNS
cord-270892-ycc3csyh	355	37	in	in	IN
cord-270892-ycc3csyh	355	38	2007	2007	CD
cord-270892-ycc3csyh	355	39	.	.	.
cord-270892-ycc3csyh	356	1	The	the	DT
cord-270892-ycc3csyh	356	2	results	result	NNS
cord-270892-ycc3csyh	356	3	were	be	VBD
cord-270892-ycc3csyh	356	4	not	not	RB
cord-270892-ycc3csyh	356	5	published	publish	VBN
cord-270892-ycc3csyh	356	6	until	until	IN
cord-270892-ycc3csyh	356	7	now	now	RB
cord-270892-ycc3csyh	356	8	.	.	.
cord-270892-ycc3csyh	357	1	Pyridazine	Pyridazine	NNP
cord-270892-ycc3csyh	357	2	analogues	analogue	NNS
cord-270892-ycc3csyh	357	3	developed	develop	VBN
cord-270892-ycc3csyh	357	4	by	by	IN
cord-270892-ycc3csyh	357	5	Janssen	Janssen	NNP
cord-270892-ycc3csyh	357	6	Research	Research	NNP
cord-270892-ycc3csyh	357	7	Foundation	Foundation	NNP
cord-270892-ycc3csyh	357	8	represent	represent	VBP
cord-270892-ycc3csyh	357	9	another	another	DT
cord-270892-ycc3csyh	357	10	example	example	NN
cord-270892-ycc3csyh	357	11	for	for	IN
cord-270892-ycc3csyh	357	12	the	the	DT
cord-270892-ycc3csyh	357	13	long	long	JJ
cord-270892-ycc3csyh	357	14	road	road	NN
cord-270892-ycc3csyh	357	15	to	to	IN
cord-270892-ycc3csyh	357	16	discovery	discovery	NN
cord-270892-ycc3csyh	357	17	of	of	IN
cord-270892-ycc3csyh	357	18	a	a	DT
cord-270892-ycc3csyh	357	19	clinically	clinically	RB
cord-270892-ycc3csyh	357	20	effective	effective	JJ
cord-270892-ycc3csyh	357	21	capsid	capsid	NN
cord-270892-ycc3csyh	357	22	-	-	HYPH
cord-270892-ycc3csyh	357	23	binder	binder	NN
cord-270892-ycc3csyh	357	24	.	.	.
cord-270892-ycc3csyh	358	1	186	186	CD
cord-270892-ycc3csyh	359	1	In	in	IN
cord-270892-ycc3csyh	359	2	1992	1992	CD
cord-270892-ycc3csyh	359	3	,	,	,
cord-270892-ycc3csyh	359	4	the	the	DT
cord-270892-ycc3csyh	359	5	broad	broad	JJ
cord-270892-ycc3csyh	359	6	-	-	HYPH
cord-270892-ycc3csyh	359	7	spectrum	spectrum	NN
cord-270892-ycc3csyh	359	8	activity	activity	NN
cord-270892-ycc3csyh	359	9	of	of	IN
cord-270892-ycc3csyh	359	10	pirodavir	pirodavir	NNP
cord-270892-ycc3csyh	359	11	(	(	-LRB-
cord-270892-ycc3csyh	359	12	Fig	Fig	NNP
cord-270892-ycc3csyh	359	13	.	.	NNP
cord-270892-ycc3csyh	359	14	2	2	CD
cord-270892-ycc3csyh	359	15	;	;	:
cord-270892-ycc3csyh	359	16	Table	Table	NNP
cord-270892-ycc3csyh	359	17	II	II	NNP
cord-270892-ycc3csyh	359	18	)	)	-RRB-
cord-270892-ycc3csyh	359	19	against	against	IN
cord-270892-ycc3csyh	359	20	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	359	21	was	be	VBD
cord-270892-ycc3csyh	359	22	published	publish	VBN
cord-270892-ycc3csyh	359	23	.	.	.
cord-270892-ycc3csyh	360	1	187	187	CD
cord-270892-ycc3csyh	361	1	In	in	IN
cord-270892-ycc3csyh	361	2	the	the	DT
cord-270892-ycc3csyh	361	3	same	same	JJ
cord-270892-ycc3csyh	361	4	year	year	NN
cord-270892-ycc3csyh	361	5	the	the	DT
cord-270892-ycc3csyh	361	6	results	result	NNS
cord-270892-ycc3csyh	361	7	of	of	IN
cord-270892-ycc3csyh	361	8	a	a	DT
cord-270892-ycc3csyh	361	9	randomized	randomized	JJ
cord-270892-ycc3csyh	361	10	,	,	,
cord-270892-ycc3csyh	361	11	double	double	JJ
cord-270892-ycc3csyh	361	12	-	-	HYPH
cord-270892-ycc3csyh	361	13	blind	blind	JJ
cord-270892-ycc3csyh	361	14	,	,	,
cord-270892-ycc3csyh	361	15	placebo	placebo	NN
cord-270892-ycc3csyh	361	16	-	-	HYPH
cord-270892-ycc3csyh	361	17	controlled	control	VBN
cord-270892-ycc3csyh	361	18	trail	trail	NN
cord-270892-ycc3csyh	361	19	to	to	TO
cord-270892-ycc3csyh	361	20	assess	assess	VB
cord-270892-ycc3csyh	361	21	the	the	DT
cord-270892-ycc3csyh	361	22	therapeutic	therapeutic	JJ
cord-270892-ycc3csyh	361	23	efficacy	efficacy	NN
cord-270892-ycc3csyh	361	24	of	of	IN
cord-270892-ycc3csyh	361	25	intranasal	intranasal	NN
cord-270892-ycc3csyh	361	26	pirodavir	pirodavir	NNP
cord-270892-ycc3csyh	361	27	in	in	IN
cord-270892-ycc3csyh	361	28	natural	natural	JJ
cord-270892-ycc3csyh	361	29	common	common	JJ
cord-270892-ycc3csyh	361	30	colds	cold	NNS
cord-270892-ycc3csyh	361	31	were	be	VBD
cord-270892-ycc3csyh	361	32	described	describe	VBN
cord-270892-ycc3csyh	361	33	.	.	.
cord-270892-ycc3csyh	362	1	205	205	CD
cord-270892-ycc3csyh	362	2	Possibly	possibly	RB
cord-270892-ycc3csyh	362	3	as	as	IN
cord-270892-ycc3csyh	362	4	a	a	DT
cord-270892-ycc3csyh	362	5	result	result	NN
cord-270892-ycc3csyh	362	6	of	of	IN
cord-270892-ycc3csyh	362	7	poor	poor	JJ
cord-270892-ycc3csyh	362	8	water	water	NN
cord-270892-ycc3csyh	362	9	solubility	solubility	NN
cord-270892-ycc3csyh	362	10	and	and	CC
cord-270892-ycc3csyh	362	11	rapid	rapid	JJ
cord-270892-ycc3csyh	362	12	hydrolysis	hydrolysis	NN
cord-270892-ycc3csyh	362	13	of	of	IN
cord-270892-ycc3csyh	362	14	pirodavir	pirodavir	NNP
cord-270892-ycc3csyh	362	15	,	,	,
cord-270892-ycc3csyh	362	16	no	no	DT
cord-270892-ycc3csyh	362	17	clinical	clinical	JJ
cord-270892-ycc3csyh	362	18	benefit	benefit	NN
cord-270892-ycc3csyh	362	19	was	be	VBD
cord-270892-ycc3csyh	362	20	found	find	VBN
cord-270892-ycc3csyh	362	21	.	.	.
cord-270892-ycc3csyh	363	1	The	the	DT
cord-270892-ycc3csyh	363	2	problem	problem	NN
cord-270892-ycc3csyh	363	3	of	of	IN
cord-270892-ycc3csyh	363	4	ester	ester	NN
cord-270892-ycc3csyh	363	5	hydrolysis	hydrolysis	NN
cord-270892-ycc3csyh	363	6	was	be	VBD
cord-270892-ycc3csyh	363	7	resolved	resolve	VBN
cord-270892-ycc3csyh	363	8	by	by	IN
cord-270892-ycc3csyh	363	9	the	the	DT
cord-270892-ycc3csyh	363	10	development	development	NN
cord-270892-ycc3csyh	363	11	of	of	IN
cord-270892-ycc3csyh	363	12	oxime	oxime	NN
cord-270892-ycc3csyh	363	13	ether	ether	NN
cord-270892-ycc3csyh	363	14	analogues	analogue	NNS
cord-270892-ycc3csyh	363	15	of	of	IN
cord-270892-ycc3csyh	363	16	pirodavir	pirodavir	NNS
cord-270892-ycc3csyh	363	17	by	by	IN
cord-270892-ycc3csyh	363	18	Biota	Biota	NNP
cord-270892-ycc3csyh	363	19	.	.	.
cord-270892-ycc3csyh	364	1	An	an	DT
cord-270892-ycc3csyh	364	2	example	example	NN
cord-270892-ycc3csyh	364	3	is	be	VBZ
cord-270892-ycc3csyh	364	4	shown	show	VBN
cord-270892-ycc3csyh	364	5	in	in	IN
cord-270892-ycc3csyh	364	6	Figure	figure	NN
cord-270892-ycc3csyh	364	7	2	2	CD
cord-270892-ycc3csyh	364	8	.	.	.
cord-270892-ycc3csyh	365	1	Like	like	IN
cord-270892-ycc3csyh	365	2	pirodavir	pirodavir	NNP
cord-270892-ycc3csyh	365	3	these	these	DT
cord-270892-ycc3csyh	365	4	new	new	JJ
cord-270892-ycc3csyh	365	5	analogues	analogue	NNS
cord-270892-ycc3csyh	365	6	are	be	VBP
cord-270892-ycc3csyh	365	7	potent	potent	JJ
cord-270892-ycc3csyh	365	8	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	365	9	of	of	IN
cord-270892-ycc3csyh	365	10	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	365	11	.	.	.
cord-270892-ycc3csyh	366	1	142	142	CD
cord-270892-ycc3csyh	367	1	An	an	DT
cord-270892-ycc3csyh	367	2	advantage	advantage	NN
cord-270892-ycc3csyh	367	3	over	over	IN
cord-270892-ycc3csyh	367	4	pirodavir	pirodavir	NNP
cord-270892-ycc3csyh	367	5	is	be	VBZ
cord-270892-ycc3csyh	367	6	their	-PRON-	PRP$
cord-270892-ycc3csyh	367	7	improved	improve	VBN
cord-270892-ycc3csyh	367	8	bioavailability	bioavailability	NN
cord-270892-ycc3csyh	367	9	.	.	.
cord-270892-ycc3csyh	368	1	BTA-798	BTA-798	NNP
cord-270892-ycc3csyh	368	2	,	,	,
cord-270892-ycc3csyh	368	3	an	an	DT
cord-270892-ycc3csyh	368	4	antiviral	antiviral	JJ
cord-270892-ycc3csyh	368	5	analogue	analogue	NN
cord-270892-ycc3csyh	368	6	with	with	IN
cord-270892-ycc3csyh	368	7	long	long	JJ
cord-270892-ycc3csyh	368	8	half	half	JJ
cord-270892-ycc3csyh	368	9	-	-	HYPH
cord-270892-ycc3csyh	368	10	life	life	NN
cord-270892-ycc3csyh	368	11	and	and	CC
cord-270892-ycc3csyh	368	12	good	good	JJ
cord-270892-ycc3csyh	368	13	oral	oral	JJ
cord-270892-ycc3csyh	368	14	bioavailability	bioavailability	NN
cord-270892-ycc3csyh	368	15	,	,	,
cord-270892-ycc3csyh	368	16	was	be	VBD
cord-270892-ycc3csyh	368	17	scheduled	schedule	VBN
cord-270892-ycc3csyh	368	18	to	to	IN
cord-270892-ycc3csyh	368	19	a	a	DT
cord-270892-ycc3csyh	368	20	phase	phase	NN
cord-270892-ycc3csyh	368	21	II	ii	CD
cord-270892-ycc3csyh	368	22	clinical	clinical	JJ
cord-270892-ycc3csyh	368	23	trial	trial	NN
cord-270892-ycc3csyh	368	24	in	in	IN
cord-270892-ycc3csyh	368	25	2008	2008	CD
cord-270892-ycc3csyh	368	26	.	.	.
cord-270892-ycc3csyh	369	1	The	the	DT
cord-270892-ycc3csyh	369	2	results	result	NNS
cord-270892-ycc3csyh	369	3	have	have	VBP
cord-270892-ycc3csyh	369	4	not	not	RB
cord-270892-ycc3csyh	369	5	yet	yet	RB
cord-270892-ycc3csyh	369	6	been	be	VBN
cord-270892-ycc3csyh	369	7	published	publish	VBN
cord-270892-ycc3csyh	369	8	.	.	.
cord-270892-ycc3csyh	370	1	In	in	IN
cord-270892-ycc3csyh	370	2	summary	summary	NN
cord-270892-ycc3csyh	370	3	,	,	,
cord-270892-ycc3csyh	370	4	despite	despite	IN
cord-270892-ycc3csyh	370	5	extensive	extensive	JJ
cord-270892-ycc3csyh	370	6	research	research	NN
cord-270892-ycc3csyh	370	7	leading	lead	VBG
cord-270892-ycc3csyh	370	8	to	to	IN
cord-270892-ycc3csyh	370	9	the	the	DT
cord-270892-ycc3csyh	370	10	discovery	discovery	NN
cord-270892-ycc3csyh	370	11	of	of	IN
cord-270892-ycc3csyh	370	12	potent	potent	JJ
cord-270892-ycc3csyh	370	13	anti	anti	JJ
cord-270892-ycc3csyh	370	14	-	-	JJ
cord-270892-ycc3csyh	370	15	HRV	HRV	NNP
cord-270892-ycc3csyh	370	16	capsid	capsid	NN
cord-270892-ycc3csyh	370	17	-	-	HYPH
cord-270892-ycc3csyh	370	18	binders	binder	NNS
cord-270892-ycc3csyh	370	19	,	,	,
cord-270892-ycc3csyh	370	20	no	no	DT
cord-270892-ycc3csyh	370	21	agent	agent	NN
cord-270892-ycc3csyh	370	22	has	have	VBZ
cord-270892-ycc3csyh	370	23	been	be	VBN
cord-270892-ycc3csyh	370	24	approved	approve	VBN
cord-270892-ycc3csyh	370	25	for	for	IN
cord-270892-ycc3csyh	370	26	prevention	prevention	NN
cord-270892-ycc3csyh	370	27	and/or	and/or	CC
cord-270892-ycc3csyh	370	28	therapy	therapy	NN
cord-270892-ycc3csyh	370	29	of	of	IN
cord-270892-ycc3csyh	370	30	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	370	31	-	-	HYPH
cord-270892-ycc3csyh	370	32	induced	induce	VBN
cord-270892-ycc3csyh	370	33	diseases	disease	NNS
cord-270892-ycc3csyh	370	34	so	so	RB
cord-270892-ycc3csyh	370	35	far	far	RB
cord-270892-ycc3csyh	370	36	.	.	.
cord-270892-ycc3csyh	371	1	Nearly	nearly	RB
cord-270892-ycc3csyh	371	2	,	,	,
cord-270892-ycc3csyh	371	3	the	the	DT
cord-270892-ycc3csyh	371	4	same	same	JJ
cord-270892-ycc3csyh	371	5	conclusion	conclusion	NN
cord-270892-ycc3csyh	371	6	has	have	VBZ
cord-270892-ycc3csyh	371	7	to	to	TO
cord-270892-ycc3csyh	371	8	be	be	VB
cord-270892-ycc3csyh	371	9	drawn	draw	VBN
cord-270892-ycc3csyh	371	10	for	for	IN
cord-270892-ycc3csyh	371	11	protease	protease	NN
cord-270892-ycc3csyh	371	12	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	371	13	.	.	.
cord-270892-ycc3csyh	372	1	Because	because	IN
cord-270892-ycc3csyh	372	2	of	of	IN
cord-270892-ycc3csyh	372	3	their	-PRON-	PRP$
cord-270892-ycc3csyh	372	4	pivotal	pivotal	JJ
cord-270892-ycc3csyh	372	5	role	role	NN
cord-270892-ycc3csyh	372	6	for	for	IN
cord-270892-ycc3csyh	372	7	viral	viral	JJ
cord-270892-ycc3csyh	372	8	polyprotein	polyprotein	JJ
cord-270892-ycc3csyh	372	9	processing	processing	NN
cord-270892-ycc3csyh	372	10	and	and	CC
cord-270892-ycc3csyh	372	11	the	the	DT
cord-270892-ycc3csyh	372	12	high	high	JJ
cord-270892-ycc3csyh	372	13	conservation	conservation	NN
cord-270892-ycc3csyh	372	14	of	of	IN
cord-270892-ycc3csyh	372	15	critical	critical	JJ
cord-270892-ycc3csyh	372	16	amino	amino	NN
cord-270892-ycc3csyh	372	17	acids	acid	NNS
cord-270892-ycc3csyh	372	18	,	,	,
cord-270892-ycc3csyh	372	19	132	132	CD
cord-270892-ycc3csyh	372	20	2A	2a	CD
cord-270892-ycc3csyh	372	21	pro	pro	JJ
cord-270892-ycc3csyh	372	22	as	as	RB
cord-270892-ycc3csyh	372	23	well	well	RB
cord-270892-ycc3csyh	372	24	as	as	IN
cord-270892-ycc3csyh	372	25	3C	3C	NNP
cord-270892-ycc3csyh	372	26	pro	pro	NNP
cord-270892-ycc3csyh	372	27	represent	represent	VBP
cord-270892-ycc3csyh	372	28	potential	potential	JJ
cord-270892-ycc3csyh	372	29	anti	anti	JJ
cord-270892-ycc3csyh	372	30	-	-	JJ
cord-270892-ycc3csyh	372	31	HRV	HRV	NNP
cord-270892-ycc3csyh	372	32	targets	target	NNS
cord-270892-ycc3csyh	372	33	.	.	.
cord-270892-ycc3csyh	373	1	Results	result	NNS
cord-270892-ycc3csyh	373	2	from	from	IN
cord-270892-ycc3csyh	373	3	cell	cell	NN
cord-270892-ycc3csyh	373	4	culture	culture	NN
cord-270892-ycc3csyh	373	5	-	-	HYPH
cord-270892-ycc3csyh	373	6	based	base	VBN
cord-270892-ycc3csyh	373	7	assays	assay	NNS
cord-270892-ycc3csyh	373	8	provided	provide	VBD
cord-270892-ycc3csyh	373	9	evidence	evidence	NN
cord-270892-ycc3csyh	373	10	that	that	IN
cord-270892-ycc3csyh	373	11	inhibition	inhibition	NN
cord-270892-ycc3csyh	373	12	of	of	IN
cord-270892-ycc3csyh	373	13	HRV	HRV	NNP
cord-270892-ycc3csyh	373	14	replication	replication	NN
cord-270892-ycc3csyh	373	15	is	be	VBZ
cord-270892-ycc3csyh	373	16	in	in	IN
cord-270892-ycc3csyh	373	17	principle	principle	JJ
cord-270892-ycc3csyh	373	18	possible	possible	JJ
cord-270892-ycc3csyh	373	19	.	.	.
cord-270892-ycc3csyh	374	1	For	for	IN
cord-270892-ycc3csyh	374	2	example	example	NN
cord-270892-ycc3csyh	374	3	,	,	,
cord-270892-ycc3csyh	374	4	processing	processing	NN
cord-270892-ycc3csyh	374	5	of	of	IN
cord-270892-ycc3csyh	374	6	the	the	DT
cord-270892-ycc3csyh	374	7	HRV-2	HRV-2	NNP
cord-270892-ycc3csyh	374	8	polyprotein	polyprotein	NN
cord-270892-ycc3csyh	374	9	was	be	VBD
cord-270892-ycc3csyh	374	10	prevented	prevent	VBN
cord-270892-ycc3csyh	374	11	by	by	IN
cord-270892-ycc3csyh	374	12	pyrrolidine	pyrrolidine	NNP
cord-270892-ycc3csyh	374	13	dithiocarbamate	dithiocarbamate	NNP
cord-270892-ycc3csyh	374	14	treatment	treatment	NN
cord-270892-ycc3csyh	374	15	in	in	IN
cord-270892-ycc3csyh	374	16	virus	virus	NN
cord-270892-ycc3csyh	374	17	-	-	HYPH
cord-270892-ycc3csyh	374	18	infected	infect	VBN
cord-270892-ycc3csyh	374	19	HeLa	HeLa	NNP
cord-270892-ycc3csyh	374	20	cells	cell	NNS
cord-270892-ycc3csyh	374	21	.	.	.
cord-270892-ycc3csyh	375	1	206	206	CD
cord-270892-ycc3csyh	376	1	In	in	IN
cord-270892-ycc3csyh	376	2	contrast	contrast	NN
cord-270892-ycc3csyh	376	3	to	to	IN
cord-270892-ycc3csyh	376	4	other	other	JJ
cord-270892-ycc3csyh	376	5	enteroviruses	enterovirus	NNS
cord-270892-ycc3csyh	376	6	,	,	,
cord-270892-ycc3csyh	376	7	[	[	-LRB-
cord-270892-ycc3csyh	376	8	207	207	CD
cord-270892-ycc3csyh	376	9	]	]	-RRB-
cord-270892-ycc3csyh	376	10	[	[	-LRB-
cord-270892-ycc3csyh	376	11	208	208	CD
cord-270892-ycc3csyh	376	12	]	]	-RRB-
cord-270892-ycc3csyh	376	13	[	[	-LRB-
cord-270892-ycc3csyh	376	14	209	209	CD
cord-270892-ycc3csyh	376	15	]	]	-RRB-
cord-270892-ycc3csyh	376	16	[	[	-LRB-
cord-270892-ycc3csyh	376	17	210	210	CD
cord-270892-ycc3csyh	376	18	]	]	-RRB-
cord-270892-ycc3csyh	376	19	pretreatment	pretreatment	NN
cord-270892-ycc3csyh	376	20	of	of	IN
cord-270892-ycc3csyh	376	21	cell	cell	NN
cord-270892-ycc3csyh	376	22	monolayers	monolayer	NNS
cord-270892-ycc3csyh	376	23	with	with	IN
cord-270892-ycc3csyh	376	24	different	different	JJ
cord-270892-ycc3csyh	376	25	nitric	nitric	NN
cord-270892-ycc3csyh	376	26	oxide	oxide	NN
cord-270892-ycc3csyh	376	27	donors	donor	NNS
cord-270892-ycc3csyh	376	28	leading	lead	VBG
cord-270892-ycc3csyh	376	29	to	to	IN
cord-270892-ycc3csyh	376	30	S	s	NN
cord-270892-ycc3csyh	376	31	-	-	HYPH
cord-270892-ycc3csyh	376	32	nitrosylation	nitrosylation	NN
cord-270892-ycc3csyh	376	33	of	of	IN
cord-270892-ycc3csyh	376	34	2A	2A	NNP
cord-270892-ycc3csyh	376	35	pro	pro	NNP
cord-270892-ycc3csyh	376	36	and	and	CC
cord-270892-ycc3csyh	376	37	3C	3C	NNP
cord-270892-ycc3csyh	376	38	pro	pro	NNP
cord-270892-ycc3csyh	376	39	had	have	VBD
cord-270892-ycc3csyh	376	40	neither	neither	CC
cord-270892-ycc3csyh	376	41	an	an	DT
cord-270892-ycc3csyh	376	42	effect	effect	NN
cord-270892-ycc3csyh	376	43	on	on	IN
cord-270892-ycc3csyh	376	44	virus	virus	NN
cord-270892-ycc3csyh	376	45	replication	replication	NN
cord-270892-ycc3csyh	376	46	nor	nor	CC
cord-270892-ycc3csyh	376	47	on	on	IN
cord-270892-ycc3csyh	376	48	HRV	HRV	NNP
cord-270892-ycc3csyh	376	49	-	-	HYPH
cord-270892-ycc3csyh	376	50	induced	induce	VBN
cord-270892-ycc3csyh	376	51	IL-8	il-8	NN
cord-270892-ycc3csyh	376	52	elaboration	elaboration	NN
cord-270892-ycc3csyh	376	53	.	.	.
cord-270892-ycc3csyh	377	1	211	211	CD
cord-270892-ycc3csyh	378	1	The	the	DT
cord-270892-ycc3csyh	378	2	proteolytic	proteolytic	JJ
cord-270892-ycc3csyh	378	3	activity	activity	NN
cord-270892-ycc3csyh	378	4	of	of	IN
cord-270892-ycc3csyh	378	5	2A	2a	CD
cord-270892-ycc3csyh	378	6	pro	pro	NN
cord-270892-ycc3csyh	378	7	of	of	IN
cord-270892-ycc3csyh	378	8	HRV-14	HRV-14	NNP
cord-270892-ycc3csyh	378	9	was	be	VBD
cord-270892-ycc3csyh	378	10	specifically	specifically	RB
cord-270892-ycc3csyh	378	11	inhibited	inhibit	VBN
cord-270892-ycc3csyh	378	12	by	by	IN
cord-270892-ycc3csyh	378	13	two	two	CD
cord-270892-ycc3csyh	378	14	elastase	elastase	NN
cord-270892-ycc3csyh	378	15	-	-	HYPH
cord-270892-ycc3csyh	378	16	specific	specific	JJ
cord-270892-ycc3csyh	378	17	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	378	18	,	,	,
cord-270892-ycc3csyh	378	19	212	212	CD
cord-270892-ycc3csyh	378	20	and	and	CC
cord-270892-ycc3csyh	378	21	an	an	DT
cord-270892-ycc3csyh	378	22	antiviral	antiviral	JJ
cord-270892-ycc3csyh	378	23	peptide	peptide	NN
cord-270892-ycc3csyh	378	24	representing	represent	VBG
cord-270892-ycc3csyh	378	25	a	a	DT
cord-270892-ycc3csyh	378	26	derivative	derivative	NN
cord-270892-ycc3csyh	378	27	of	of	IN
cord-270892-ycc3csyh	378	28	the	the	DT
cord-270892-ycc3csyh	378	29	caspase	caspase	NN
cord-270892-ycc3csyh	378	30	inhibitor	inhibitor	NN
cord-270892-ycc3csyh	378	31	zVAD.fmk	zVAD.fmk	NNS
cord-270892-ycc3csyh	378	32	.	.	.
cord-270892-ycc3csyh	379	1	213	213	CD
cord-270892-ycc3csyh	379	2	,	,	,
cord-270892-ycc3csyh	379	3	214	214	CD
cord-270892-ycc3csyh	379	4	Homophthalimides	homophthalimide	NNS
cord-270892-ycc3csyh	379	5	,	,	,
cord-270892-ycc3csyh	379	6	e.g.	e.g.	RB
cord-270892-ycc3csyh	379	7	LY353349	LY353349	NNP
cord-270892-ycc3csyh	379	8	(	(	-LRB-
cord-270892-ycc3csyh	379	9	Fig	Fig	NNP
cord-270892-ycc3csyh	379	10	.	.	.
cord-270892-ycc3csyh	379	11	3	3	CD
cord-270892-ycc3csyh	379	12	;	;	:
cord-270892-ycc3csyh	379	13	Table	Table	NNP
cord-270892-ycc3csyh	379	14	II	II	NNP
cord-270892-ycc3csyh	379	15	)	)	-RRB-
cord-270892-ycc3csyh	379	16	,	,	,
cord-270892-ycc3csyh	379	17	were	be	VBD
cord-270892-ycc3csyh	379	18	described	describe	VBN
cord-270892-ycc3csyh	379	19	as	as	IN
cord-270892-ycc3csyh	379	20	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	379	21	of	of	IN
cord-270892-ycc3csyh	379	22	2A	2a	CD
cord-270892-ycc3csyh	379	23	pro	pro	NNP
cord-270892-ycc3csyh	379	24	as	as	RB
cord-270892-ycc3csyh	379	25	well	well	RB
cord-270892-ycc3csyh	379	26	as	as	IN
cord-270892-ycc3csyh	379	27	3C	3C	NNP
cord-270892-ycc3csyh	379	28	pro	pro	NNP
cord-270892-ycc3csyh	379	29	.	.	NNP
cord-270892-ycc3csyh	379	30	215	215	CD
cord-270892-ycc3csyh	380	1	In	in	IN
cord-270892-ycc3csyh	380	2	contrast	contrast	NN
cord-270892-ycc3csyh	380	3	to	to	IN
cord-270892-ycc3csyh	380	4	protease	protease	NN
cord-270892-ycc3csyh	380	5	3C	3C	NNP
cord-270892-ycc3csyh	380	6	,	,	,
cord-270892-ycc3csyh	380	7	no	no	DT
cord-270892-ycc3csyh	380	8	structure	structure	NN
cord-270892-ycc3csyh	380	9	-	-	HYPH
cord-270892-ycc3csyh	380	10	activity	activity	NN
cord-270892-ycc3csyh	380	11	relationship	relationship	NN
cord-270892-ycc3csyh	380	12	studies	study	NNS
cord-270892-ycc3csyh	380	13	have	have	VBP
cord-270892-ycc3csyh	380	14	been	be	VBN
cord-270892-ycc3csyh	380	15	reported	report	VBN
cord-270892-ycc3csyh	380	16	for	for	IN
cord-270892-ycc3csyh	380	17	HRV	HRV	NNP
cord-270892-ycc3csyh	380	18	2A	2a	CD
cord-270892-ycc3csyh	380	19	protease	protease	NN
cord-270892-ycc3csyh	380	20	.	.	.
cord-270892-ycc3csyh	381	1	Moreover	moreover	RB
cord-270892-ycc3csyh	381	2	,	,	,
cord-270892-ycc3csyh	381	3	protease	protease	NN
cord-270892-ycc3csyh	381	4	2A	2a	NN
cord-270892-ycc3csyh	381	5	accomplishes	accomplish	VBZ
cord-270892-ycc3csyh	381	6	only	only	RB
cord-270892-ycc3csyh	381	7	one	one	CD
cord-270892-ycc3csyh	381	8	cleavage	cleavage	NN
cord-270892-ycc3csyh	381	9	in	in	IN
cord-270892-ycc3csyh	381	10	HRV	HRV	NNP
cord-270892-ycc3csyh	381	11	polyprotein	polyprotein	NNP
cord-270892-ycc3csyh	381	12	,	,	,
cord-270892-ycc3csyh	381	13	while	while	IN
cord-270892-ycc3csyh	381	14	protease	protease	NN
cord-270892-ycc3csyh	381	15	3C	3C	NNP
cord-270892-ycc3csyh	381	16	performs	perform	VBZ
cord-270892-ycc3csyh	381	17	all	all	DT
cord-270892-ycc3csyh	381	18	other	other	JJ
cord-270892-ycc3csyh	381	19	cleavages	cleavage	NNS
cord-270892-ycc3csyh	381	20	.	.	.
cord-270892-ycc3csyh	382	1	After	after	IN
cord-270892-ycc3csyh	382	2	elucidation	elucidation	NN
cord-270892-ycc3csyh	382	3	of	of	IN
cord-270892-ycc3csyh	382	4	the	the	DT
cord-270892-ycc3csyh	382	5	crystal	crystal	JJ
cord-270892-ycc3csyh	382	6	structure	structure	NN
cord-270892-ycc3csyh	382	7	of	of	IN
cord-270892-ycc3csyh	382	8	3C	3C	NNP
cord-270892-ycc3csyh	382	9	pro	pro	NNP
cord-270892-ycc3csyh	382	10	,	,	,
cord-270892-ycc3csyh	382	11	216	216	CD
cord-270892-ycc3csyh	382	12	computer	computer	NN
cord-270892-ycc3csyh	382	13	modeling	modeling	NN
cord-270892-ycc3csyh	382	14	of	of	IN
cord-270892-ycc3csyh	382	15	structural	structural	JJ
cord-270892-ycc3csyh	382	16	features	feature	NNS
cord-270892-ycc3csyh	382	17	of	of	IN
cord-270892-ycc3csyh	382	18	protease	protease	NN
cord-270892-ycc3csyh	382	19	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	382	20	became	become	VBD
cord-270892-ycc3csyh	382	21	possible	possible	JJ
cord-270892-ycc3csyh	382	22	.	.	.
cord-270892-ycc3csyh	383	1	217	217	CD
cord-270892-ycc3csyh	384	1	Furthermore	furthermore	RB
cord-270892-ycc3csyh	384	2	,	,	,
cord-270892-ycc3csyh	384	3	structure	structure	NN
cord-270892-ycc3csyh	384	4	-	-	HYPH
cord-270892-ycc3csyh	384	5	based	base	VBN
cord-270892-ycc3csyh	384	6	design	design	NN
cord-270892-ycc3csyh	384	7	was	be	VBD
cord-270892-ycc3csyh	384	8	used	use	VBN
cord-270892-ycc3csyh	384	9	to	to	TO
cord-270892-ycc3csyh	384	10	develop	develop	VB
cord-270892-ycc3csyh	384	11	mechanism	mechanism	NN
cord-270892-ycc3csyh	384	12	-	-	HYPH
cord-270892-ycc3csyh	384	13	based	base	VBN
cord-270892-ycc3csyh	384	14	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	384	15	of	of	IN
cord-270892-ycc3csyh	384	16	the	the	DT
cord-270892-ycc3csyh	384	17	3C	3C	NNP
cord-270892-ycc3csyh	384	18	protease	protease	NN
cord-270892-ycc3csyh	384	19	with	with	IN
cord-270892-ycc3csyh	384	20	potent	potent	JJ
cord-270892-ycc3csyh	384	21	antiviral	antiviral	JJ
cord-270892-ycc3csyh	384	22	activity	activity	NN
cord-270892-ycc3csyh	384	23	against	against	IN
cord-270892-ycc3csyh	384	24	multiple	multiple	JJ
cord-270892-ycc3csyh	384	25	HRV	HRV	NNP
cord-270892-ycc3csyh	384	26	serotypes	serotype	NNS
cord-270892-ycc3csyh	384	27	.	.	.
cord-270892-ycc3csyh	385	1	218	218	CD
cord-270892-ycc3csyh	385	2	,	,	,
cord-270892-ycc3csyh	385	3	219	219	CD
cord-270892-ycc3csyh	385	4	Highly	highly	RB
cord-270892-ycc3csyh	385	5	active	active	JJ
cord-270892-ycc3csyh	385	6	compounds	compound	NNS
cord-270892-ycc3csyh	385	7	incorporate	incorporate	VBP
cord-270892-ycc3csyh	385	8	various	various	JJ
cord-270892-ycc3csyh	385	9	Michael	Michael	NNP
cord-270892-ycc3csyh	385	10	acceptor	acceptor	NN
cord-270892-ycc3csyh	385	11	moieties	moiety	NNS
cord-270892-ycc3csyh	385	12	,	,	,
cord-270892-ycc3csyh	385	13	irreversibly	irreversibly	RB
cord-270892-ycc3csyh	385	14	bind	bind	VBP
cord-270892-ycc3csyh	385	15	to	to	IN
cord-270892-ycc3csyh	385	16	3C	3C	NNP
cord-270892-ycc3csyh	385	17	pro	pro	NNP
cord-270892-ycc3csyh	385	18	,	,	,
cord-270892-ycc3csyh	385	19	and	and	CC
cord-270892-ycc3csyh	385	20	exhibit	exhibit	VB
cord-270892-ycc3csyh	385	21	anti	anti	JJ
cord-270892-ycc3csyh	385	22	-	-	JJ
cord-270892-ycc3csyh	385	23	HRV-14	hrv-14	JJ
cord-270892-ycc3csyh	385	24	activity	activity	NN
cord-270892-ycc3csyh	385	25	in	in	IN
cord-270892-ycc3csyh	385	26	HeLa	HeLa	NNP
cord-270892-ycc3csyh	385	27	cells	cell	NNS
cord-270892-ycc3csyh	385	28	.	.	.
cord-270892-ycc3csyh	386	1	220	220	CD
cord-270892-ycc3csyh	386	2	,	,	,
cord-270892-ycc3csyh	386	3	221	221	CD
cord-270892-ycc3csyh	386	4	Structure	structure	NN
cord-270892-ycc3csyh	386	5	-	-	HYPH
cord-270892-ycc3csyh	386	6	activity	activity	NN
cord-270892-ycc3csyh	386	7	studies	study	NNS
cord-270892-ycc3csyh	386	8	were	be	VBD
cord-270892-ycc3csyh	386	9	performed	perform	VBN
cord-270892-ycc3csyh	386	10	to	to	TO
cord-270892-ycc3csyh	386	11	optimize	optimize	VB
cord-270892-ycc3csyh	386	12	protease	protease	NN
cord-270892-ycc3csyh	386	13	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	386	14	.	.	.
cord-270892-ycc3csyh	387	1	220	220	CD
cord-270892-ycc3csyh	387	2	,	,	,
cord-270892-ycc3csyh	387	3	[	[	-LRB-
cord-270892-ycc3csyh	387	4	222	222	CD
cord-270892-ycc3csyh	387	5	]	]	-RRB-
cord-270892-ycc3csyh	387	6	[	[	-LRB-
cord-270892-ycc3csyh	387	7	223	223	CD
cord-270892-ycc3csyh	387	8	]	]	-RRB-
cord-270892-ycc3csyh	387	9	[	[	-LRB-
cord-270892-ycc3csyh	387	10	224	224	CD
cord-270892-ycc3csyh	387	11	]	]	-RRB-
cord-270892-ycc3csyh	387	12	[	[	-LRB-
cord-270892-ycc3csyh	387	13	225	225	CD
cord-270892-ycc3csyh	387	14	]	]	-RRB-
cord-270892-ycc3csyh	387	15	[	[	-LRB-
cord-270892-ycc3csyh	387	16	226	226	CD
cord-270892-ycc3csyh	387	17	]	]	-RRB-
cord-270892-ycc3csyh	388	1	These	these	DT
cord-270892-ycc3csyh	388	2	efforts	effort	NNS
cord-270892-ycc3csyh	388	3	resulted	result	VBD
cord-270892-ycc3csyh	388	4	in	in	IN
cord-270892-ycc3csyh	388	5	the	the	DT
cord-270892-ycc3csyh	388	6	identification	identification	NN
cord-270892-ycc3csyh	388	7	of	of	IN
cord-270892-ycc3csyh	388	8	a	a	DT
cord-270892-ycc3csyh	388	9	highly	highly	RB
cord-270892-ycc3csyh	388	10	active	active	JJ
cord-270892-ycc3csyh	388	11	anti	anti	JJ
cord-270892-ycc3csyh	388	12	-	-	JJ
cord-270892-ycc3csyh	388	13	HRV	HRV	NNP
cord-270892-ycc3csyh	388	14	compound	compound	NN
cord-270892-ycc3csyh	388	15	,	,	,
cord-270892-ycc3csyh	388	16	AG7088	AG7088	NNP
cord-270892-ycc3csyh	388	17	(	(	-LRB-
cord-270892-ycc3csyh	388	18	rupintrivir	rupintrivir	NNP
cord-270892-ycc3csyh	388	19	;	;	:
cord-270892-ycc3csyh	388	20	Fig	Fig	NNP
cord-270892-ycc3csyh	388	21	.	.	.
cord-270892-ycc3csyh	388	22	3	3	CD
cord-270892-ycc3csyh	388	23	;	;	:
cord-270892-ycc3csyh	388	24	Table	Table	NNP
cord-270892-ycc3csyh	388	25	II	ii	CD
cord-270892-ycc3csyh	388	26	)	)	-RRB-
cord-270892-ycc3csyh	388	27	that	that	WDT
cord-270892-ycc3csyh	388	28	entered	enter	VBD
cord-270892-ycc3csyh	388	29	clinical	clinical	JJ
cord-270892-ycc3csyh	388	30	trials	trial	NNS
cord-270892-ycc3csyh	388	31	.	.	.
cord-270892-ycc3csyh	389	1	In	in	IN
cord-270892-ycc3csyh	389	2	cell	cell	NN
cord-270892-ycc3csyh	389	3	culture	culture	NN
cord-270892-ycc3csyh	389	4	,	,	,
cord-270892-ycc3csyh	389	5	AG7088	ag7088	NN
cord-270892-ycc3csyh	389	6	inhibited	inhibit	VBD
cord-270892-ycc3csyh	389	7	a	a	DT
cord-270892-ycc3csyh	389	8	broad	broad	JJ
cord-270892-ycc3csyh	389	9	spectrum	spectrum	NN
cord-270892-ycc3csyh	389	10	of	of	IN
cord-270892-ycc3csyh	389	11	laboratory	laboratory	NN
cord-270892-ycc3csyh	389	12	HRV	HRV	NNP
cord-270892-ycc3csyh	389	13	as	as	RB
cord-270892-ycc3csyh	389	14	well	well	RB
cord-270892-ycc3csyh	389	15	as	as	IN
cord-270892-ycc3csyh	389	16	clinical	clinical	JJ
cord-270892-ycc3csyh	389	17	isolates	isolate	NNS
cord-270892-ycc3csyh	389	18	.	.	.
cord-270892-ycc3csyh	390	1	132	132	CD
cord-270892-ycc3csyh	390	2	,	,	,
cord-270892-ycc3csyh	390	3	183	183	CD
cord-270892-ycc3csyh	390	4	,	,	,
cord-270892-ycc3csyh	390	5	227	227	CD
cord-270892-ycc3csyh	391	1	In	in	IN
cord-270892-ycc3csyh	391	2	a	a	DT
cord-270892-ycc3csyh	391	3	single	single	JJ
cord-270892-ycc3csyh	391	4	-	-	HYPH
cord-270892-ycc3csyh	391	5	cycle	cycle	NN
cord-270892-ycc3csyh	391	6	,	,	,
cord-270892-ycc3csyh	391	7	time	time	NN
cord-270892-ycc3csyh	391	8	-	-	HYPH
cord-270892-ycc3csyh	391	9	of	of	IN
cord-270892-ycc3csyh	391	10	-	-	HYPH
cord-270892-ycc3csyh	391	11	addition	addition	NN
cord-270892-ycc3csyh	391	12	assay	assay	NN
cord-270892-ycc3csyh	391	13	it	-PRON-	PRP
cord-270892-ycc3csyh	391	14	demonstrated	demonstrate	VBD
cord-270892-ycc3csyh	391	15	antiviral	antiviral	JJ
cord-270892-ycc3csyh	391	16	activity	activity	NN
cord-270892-ycc3csyh	391	17	when	when	WRB
cord-270892-ycc3csyh	391	18	added	add	VBN
cord-270892-ycc3csyh	391	19	up	up	RP
cord-270892-ycc3csyh	391	20	to	to	TO
cord-270892-ycc3csyh	391	21	6	6	CD
cord-270892-ycc3csyh	391	22	hr	hr	NN
cord-270892-ycc3csyh	391	23	after	after	IN
cord-270892-ycc3csyh	391	24	infection	infection	NN
cord-270892-ycc3csyh	391	25	.	.	.
cord-270892-ycc3csyh	392	1	227	227	CD
cord-270892-ycc3csyh	392	2	Inhibition	inhibition	NN
cord-270892-ycc3csyh	392	3	of	of	IN
cord-270892-ycc3csyh	392	4	HRV	HRV	NNP
cord-270892-ycc3csyh	392	5	replication	replication	NN
cord-270892-ycc3csyh	392	6	strongly	strongly	RB
cord-270892-ycc3csyh	392	7	correlated	correlate	VBD
cord-270892-ycc3csyh	392	8	with	with	IN
cord-270892-ycc3csyh	392	9	reduction	reduction	NN
cord-270892-ycc3csyh	392	10	in	in	IN
cord-270892-ycc3csyh	392	11	the	the	DT
cord-270892-ycc3csyh	392	12	level	level	NN
cord-270892-ycc3csyh	392	13	of	of	IN
cord-270892-ycc3csyh	392	14	IL-6	IL-6	NNP
cord-270892-ycc3csyh	392	15	and	and	CC
cord-270892-ycc3csyh	392	16	IL-8	IL-8	NNP
cord-270892-ycc3csyh	392	17	release	release	VBP
cord-270892-ycc3csyh	392	18	into	into	IN
cord-270892-ycc3csyh	392	19	cell	cell	NN
cord-270892-ycc3csyh	392	20	supernatant	supernatant	NN
cord-270892-ycc3csyh	392	21	,	,	,
cord-270892-ycc3csyh	392	22	leading	lead	VBG
cord-270892-ycc3csyh	392	23	to	to	IN
cord-270892-ycc3csyh	392	24	the	the	DT
cord-270892-ycc3csyh	392	25	suggestion	suggestion	NN
cord-270892-ycc3csyh	392	26	that	that	IN
cord-270892-ycc3csyh	392	27	this	this	DT
cord-270892-ycc3csyh	392	28	agent	agent	NN
cord-270892-ycc3csyh	392	29	may	may	MD
cord-270892-ycc3csyh	392	30	not	not	RB
cord-270892-ycc3csyh	392	31	only	only	RB
cord-270892-ycc3csyh	392	32	block	block	VB
cord-270892-ycc3csyh	392	33	virus	virus	NN
cord-270892-ycc3csyh	392	34	replication	replication	NN
cord-270892-ycc3csyh	392	35	but	but	CC
cord-270892-ycc3csyh	392	36	also	also	RB
cord-270892-ycc3csyh	392	37	diminish	diminish	VBP
cord-270892-ycc3csyh	392	38	symptoms	symptom	NNS
cord-270892-ycc3csyh	392	39	.	.	.
cord-270892-ycc3csyh	393	1	228	228	CD
cord-270892-ycc3csyh	394	1	The	the	DT
cord-270892-ycc3csyh	394	2	pharmacokinetics	pharmacokinetic	NNS
cord-270892-ycc3csyh	394	3	and	and	CC
cord-270892-ycc3csyh	394	4	safety	safety	NN
cord-270892-ycc3csyh	394	5	of	of	IN
cord-270892-ycc3csyh	394	6	rupintrivir	rupintrivir	NNS
cord-270892-ycc3csyh	394	7	were	be	VBD
cord-270892-ycc3csyh	394	8	proved	prove	VBN
cord-270892-ycc3csyh	394	9	in	in	IN
cord-270892-ycc3csyh	394	10	two	two	CD
cord-270892-ycc3csyh	394	11	double	double	JJ
cord-270892-ycc3csyh	394	12	-	-	HYPH
cord-270892-ycc3csyh	394	13	blind	blind	JJ
cord-270892-ycc3csyh	394	14	,	,	,
cord-270892-ycc3csyh	394	15	randomized	randomized	JJ
cord-270892-ycc3csyh	394	16	,	,	,
cord-270892-ycc3csyh	394	17	placebo	placebo	NN
cord-270892-ycc3csyh	394	18	-	-	HYPH
cord-270892-ycc3csyh	394	19	controlled	control	VBN
cord-270892-ycc3csyh	394	20	studies	study	NNS
cord-270892-ycc3csyh	394	21	.	.	.
cord-270892-ycc3csyh	395	1	229	229	CD
cord-270892-ycc3csyh	395	2	Intranasal	Intranasal	NNP
cord-270892-ycc3csyh	395	3	rupintrivir	rupintrivir	NNS
cord-270892-ycc3csyh	395	4	,	,	,
cord-270892-ycc3csyh	395	5	administered	administer	VBN
cord-270892-ycc3csyh	395	6	as	as	IN
cord-270892-ycc3csyh	395	7	single	single	JJ
cord-270892-ycc3csyh	395	8	doses	dose	NNS
cord-270892-ycc3csyh	395	9	of	of	IN
cord-270892-ycc3csyh	395	10	4	4	CD
cord-270892-ycc3csyh	395	11	and	and	CC
cord-270892-ycc3csyh	395	12	8	8	CD
cord-270892-ycc3csyh	395	13	mg	mg	CD
cord-270892-ycc3csyh	395	14	or	or	CC
cord-270892-ycc3csyh	395	15	every	every	DT
cord-270892-ycc3csyh	395	16	3	3	CD
cord-270892-ycc3csyh	395	17	hr	hr	NN
cord-270892-ycc3csyh	395	18	,	,	,
cord-270892-ycc3csyh	395	19	six	six	CD
cord-270892-ycc3csyh	395	20	times	time	NNS
cord-270892-ycc3csyh	395	21	per	per	IN
cord-270892-ycc3csyh	395	22	day	day	NN
cord-270892-ycc3csyh	395	23	,	,	,
cord-270892-ycc3csyh	395	24	for	for	IN
cord-270892-ycc3csyh	395	25	7	7	CD
cord-270892-ycc3csyh	395	26	days	day	NNS
cord-270892-ycc3csyh	395	27	,	,	,
cord-270892-ycc3csyh	395	28	was	be	VBD
cord-270892-ycc3csyh	395	29	safe	safe	JJ
cord-270892-ycc3csyh	395	30	and	and	CC
cord-270892-ycc3csyh	395	31	well	well	RB
cord-270892-ycc3csyh	395	32	tolerated	tolerate	VBN
cord-270892-ycc3csyh	395	33	.	.	.
cord-270892-ycc3csyh	396	1	Three	three	CD
cord-270892-ycc3csyh	396	2	double	double	JJ
cord-270892-ycc3csyh	396	3	blind	blind	JJ
cord-270892-ycc3csyh	396	4	,	,	,
cord-270892-ycc3csyh	396	5	placebo	placebo	NN
cord-270892-ycc3csyh	396	6	-	-	HYPH
cord-270892-ycc3csyh	396	7	controlled	control	VBN
cord-270892-ycc3csyh	396	8	clinical	clinical	JJ
cord-270892-ycc3csyh	396	9	trials	trial	NNS
cord-270892-ycc3csyh	396	10	were	be	VBD
cord-270892-ycc3csyh	396	11	conducted	conduct	VBN
cord-270892-ycc3csyh	396	12	to	to	TO
cord-270892-ycc3csyh	396	13	assess	assess	VB
cord-270892-ycc3csyh	396	14	rupintrivir	rupintrivir	NNP
cord-270892-ycc3csyh	396	15	nasal	nasal	NN
cord-270892-ycc3csyh	396	16	spray	spray	NN
cord-270892-ycc3csyh	396	17	(	(	-LRB-
cord-270892-ycc3csyh	396	18	2	2	CD
cord-270892-ycc3csyh	396	19	%	%	NN
cord-270892-ycc3csyh	396	20	solution	solution	NN
cord-270892-ycc3csyh	396	21	)	)	-RRB-
cord-270892-ycc3csyh	396	22	for	for	IN
cord-270892-ycc3csyh	396	23	prevention	prevention	NN
cord-270892-ycc3csyh	396	24	and	and	CC
cord-270892-ycc3csyh	396	25	treatment	treatment	NN
cord-270892-ycc3csyh	396	26	of	of	IN
cord-270892-ycc3csyh	396	27	experimentally	experimentally	RB
cord-270892-ycc3csyh	396	28	induced	induce	VBN
cord-270892-ycc3csyh	396	29	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	396	30	colds	cold	NNS
cord-270892-ycc3csyh	396	31	in	in	IN
cord-270892-ycc3csyh	396	32	healthy	healthy	JJ
cord-270892-ycc3csyh	396	33	volunteers	volunteer	NNS
cord-270892-ycc3csyh	396	34	.	.	.
cord-270892-ycc3csyh	397	1	230	230	CD
cord-270892-ycc3csyh	397	2	Rupintrivir	Rupintrivir	NNP
cord-270892-ycc3csyh	397	3	prophylaxis	prophylaxis	NN
cord-270892-ycc3csyh	397	4	reduced	reduce	VBD
cord-270892-ycc3csyh	397	5	the	the	DT
cord-270892-ycc3csyh	397	6	proportion	proportion	NN
cord-270892-ycc3csyh	397	7	of	of	IN
cord-270892-ycc3csyh	397	8	subjects	subject	NNS
cord-270892-ycc3csyh	397	9	with	with	IN
cord-270892-ycc3csyh	397	10	positive	positive	JJ
cord-270892-ycc3csyh	397	11	viral	viral	JJ
cord-270892-ycc3csyh	397	12	culture	culture	NN
cord-270892-ycc3csyh	397	13	by	by	IN
cord-270892-ycc3csyh	397	14	26	26	CD
cord-270892-ycc3csyh	397	15	%	%	NN
cord-270892-ycc3csyh	397	16	and	and	CC
cord-270892-ycc3csyh	397	17	viral	viral	JJ
cord-270892-ycc3csyh	397	18	titers	titer	NNS
cord-270892-ycc3csyh	397	19	but	but	CC
cord-270892-ycc3csyh	397	20	did	do	VBD
cord-270892-ycc3csyh	397	21	not	not	RB
cord-270892-ycc3csyh	397	22	decrease	decrease	VB
cord-270892-ycc3csyh	397	23	the	the	DT
cord-270892-ycc3csyh	397	24	frequency	frequency	NN
cord-270892-ycc3csyh	397	25	of	of	IN
cord-270892-ycc3csyh	397	26	colds	cold	NNS
cord-270892-ycc3csyh	397	27	.	.	.
cord-270892-ycc3csyh	398	1	Drug	drug	NN
cord-270892-ycc3csyh	398	2	treatment	treatment	NN
cord-270892-ycc3csyh	398	3	led	lead	VBD
cord-270892-ycc3csyh	398	4	to	to	IN
cord-270892-ycc3csyh	398	5	the	the	DT
cord-270892-ycc3csyh	398	6	reduction	reduction	NN
cord-270892-ycc3csyh	398	7	of	of	IN
cord-270892-ycc3csyh	398	8	the	the	DT
cord-270892-ycc3csyh	398	9	mean	mean	JJ
cord-270892-ycc3csyh	398	10	total	total	JJ
cord-270892-ycc3csyh	398	11	daily	daily	JJ
cord-270892-ycc3csyh	398	12	symptom	symptom	NN
cord-270892-ycc3csyh	398	13	score	score	NN
cord-270892-ycc3csyh	398	14	by	by	IN
cord-270892-ycc3csyh	398	15	33	33	CD
cord-270892-ycc3csyh	398	16	%	%	NN
cord-270892-ycc3csyh	398	17	.	.	.
cord-270892-ycc3csyh	399	1	Subjects	subject	NNS
cord-270892-ycc3csyh	399	2	receiving	receive	VBG
cord-270892-ycc3csyh	399	3	rupintrivir	rupintrivir	NNS
cord-270892-ycc3csyh	399	4	also	also	RB
cord-270892-ycc3csyh	399	5	demonstrated	demonstrate	VBD
cord-270892-ycc3csyh	399	6	significantly	significantly	RB
cord-270892-ycc3csyh	399	7	lower	low	JJR
cord-270892-ycc3csyh	399	8	viral	viral	JJ
cord-270892-ycc3csyh	399	9	titers	titer	NNS
cord-270892-ycc3csyh	399	10	and	and	CC
cord-270892-ycc3csyh	399	11	RNA	RNA	NNP
cord-270892-ycc3csyh	399	12	levels	level	NNS
cord-270892-ycc3csyh	399	13	than	than	IN
cord-270892-ycc3csyh	399	14	placebo	placebo	NN
cord-270892-ycc3csyh	399	15	-	-	HYPH
cord-270892-ycc3csyh	399	16	treated	treat	VBN
cord-270892-ycc3csyh	399	17	subjects	subject	NNS
cord-270892-ycc3csyh	399	18	on	on	IN
cord-270892-ycc3csyh	399	19	days	day	NNS
cord-270892-ycc3csyh	399	20	2	2	CD
cord-270892-ycc3csyh	399	21	,	,	,
cord-270892-ycc3csyh	399	22	3	3	CD
cord-270892-ycc3csyh	399	23	,	,	,
cord-270892-ycc3csyh	399	24	and	and	CC
cord-270892-ycc3csyh	399	25	5	5	CD
cord-270892-ycc3csyh	399	26	and	and	CC
cord-270892-ycc3csyh	399	27	on	on	IN
cord-270892-ycc3csyh	399	28	days	day	NNS
cord-270892-ycc3csyh	399	29	2	2	CD
cord-270892-ycc3csyh	399	30	and	and	CC
cord-270892-ycc3csyh	399	31	3	3	CD
cord-270892-ycc3csyh	399	32	,	,	,
cord-270892-ycc3csyh	399	33	respectively	respectively	RB
cord-270892-ycc3csyh	399	34	.	.	.
cord-270892-ycc3csyh	400	1	There	there	EX
cord-270892-ycc3csyh	400	2	was	be	VBD
cord-270892-ycc3csyh	400	3	no	no	DT
cord-270892-ycc3csyh	400	4	influence	influence	NN
cord-270892-ycc3csyh	400	5	on	on	IN
cord-270892-ycc3csyh	400	6	the	the	DT
cord-270892-ycc3csyh	400	7	proportion	proportion	NN
cord-270892-ycc3csyh	400	8	of	of	IN
cord-270892-ycc3csyh	400	9	subjects	subject	NNS
cord-270892-ycc3csyh	400	10	with	with	IN
cord-270892-ycc3csyh	400	11	positive	positive	JJ
cord-270892-ycc3csyh	400	12	viral	viral	JJ
cord-270892-ycc3csyh	400	13	culture	culture	NN
cord-270892-ycc3csyh	400	14	and	and	CC
cord-270892-ycc3csyh	400	15	the	the	DT
cord-270892-ycc3csyh	400	16	frequency	frequency	NN
cord-270892-ycc3csyh	400	17	of	of	IN
cord-270892-ycc3csyh	400	18	colds	cold	NNS
cord-270892-ycc3csyh	400	19	.	.	.
cord-270892-ycc3csyh	401	1	Clinical	clinical	JJ
cord-270892-ycc3csyh	401	2	development	development	NN
cord-270892-ycc3csyh	401	3	was	be	VBD
cord-270892-ycc3csyh	401	4	terminated	terminate	VBN
cord-270892-ycc3csyh	401	5	because	because	IN
cord-270892-ycc3csyh	401	6	rupintrivir	rupintrivir	NNP
cord-270892-ycc3csyh	401	7	did	do	VBD
cord-270892-ycc3csyh	401	8	not	not	RB
cord-270892-ycc3csyh	401	9	act	act	VB
cord-270892-ycc3csyh	401	10	in	in	IN
cord-270892-ycc3csyh	401	11	a	a	DT
cord-270892-ycc3csyh	401	12	subsequent	subsequent	JJ
cord-270892-ycc3csyh	401	13	natural	natural	JJ
cord-270892-ycc3csyh	401	14	infection	infection	NN
cord-270892-ycc3csyh	401	15	study	study	NN
cord-270892-ycc3csyh	401	16	in	in	IN
cord-270892-ycc3csyh	401	17	patients	patient	NNS
cord-270892-ycc3csyh	401	18	.	.	.
cord-270892-ycc3csyh	402	1	231	231	CD
cord-270892-ycc3csyh	403	1	In	in	IN
cord-270892-ycc3csyh	403	2	parallel	parallel	JJ
cord-270892-ycc3csyh	403	3	research	research	NN
cord-270892-ycc3csyh	403	4	efforts	effort	NNS
cord-270892-ycc3csyh	403	5	,	,	,
cord-270892-ycc3csyh	403	6	an	an	DT
cord-270892-ycc3csyh	403	7	orally	orally	RB
cord-270892-ycc3csyh	403	8	bioavailable	bioavailable	JJ
cord-270892-ycc3csyh	403	9	inhibitor	inhibitor	NN
cord-270892-ycc3csyh	403	10	of	of	IN
cord-270892-ycc3csyh	403	11	Table	Table	NNP
cord-270892-ycc3csyh	403	12	II	II	NNP
cord-270892-ycc3csyh	403	13	)	)	-RRB-
cord-270892-ycc3csyh	403	14	,	,	,
cord-270892-ycc3csyh	403	15	was	be	VBD
cord-270892-ycc3csyh	403	16	discovered	discover	VBN
cord-270892-ycc3csyh	403	17	.	.	.
cord-270892-ycc3csyh	404	1	225	225	CD
cord-270892-ycc3csyh	404	2	,	,	,
cord-270892-ycc3csyh	404	3	231	231	CD
cord-270892-ycc3csyh	404	4	Like	like	IN
cord-270892-ycc3csyh	404	5	rupintrivir	rupintrivir	NNS
cord-270892-ycc3csyh	404	6	,	,	,
cord-270892-ycc3csyh	404	7	this	this	DT
cord-270892-ycc3csyh	404	8	compound	compound	NN
cord-270892-ycc3csyh	404	9	is	be	VBZ
cord-270892-ycc3csyh	404	10	an	an	DT
cord-270892-ycc3csyh	404	11	irreversible	irreversible	JJ
cord-270892-ycc3csyh	404	12	inhibitor	inhibitor	NN
cord-270892-ycc3csyh	404	13	incorporating	incorporate	VBG
cord-270892-ycc3csyh	404	14	a	a	DT
cord-270892-ycc3csyh	404	15	Michael	Michael	NNP
cord-270892-ycc3csyh	404	16	acceptor	acceptor	NN
cord-270892-ycc3csyh	404	17	moiety	moiety	NN
cord-270892-ycc3csyh	404	18	that	that	WDT
cord-270892-ycc3csyh	404	19	forms	form	VBZ
cord-270892-ycc3csyh	404	20	a	a	DT
cord-270892-ycc3csyh	404	21	covalent	covalent	JJ
cord-270892-ycc3csyh	404	22	bond	bond	NN
cord-270892-ycc3csyh	404	23	with	with	IN
cord-270892-ycc3csyh	404	24	the	the	DT
cord-270892-ycc3csyh	404	25	3C	3C	NNP
cord-270892-ycc3csyh	404	26	protease	protease	NN
cord-270892-ycc3csyh	404	27	active	active	JJ
cord-270892-ycc3csyh	404	28	site	site	NN
cord-270892-ycc3csyh	404	29	cysteine	cysteine	NN
cord-270892-ycc3csyh	404	30	.	.	.
cord-270892-ycc3csyh	405	1	It	-PRON-	PRP
cord-270892-ycc3csyh	405	2	demonstrated	demonstrate	VBD
cord-270892-ycc3csyh	405	3	an	an	DT
cord-270892-ycc3csyh	405	4	antiviral	antiviral	JJ
cord-270892-ycc3csyh	405	5	activity	activity	NN
cord-270892-ycc3csyh	405	6	against	against	IN
cord-270892-ycc3csyh	405	7	all	all	DT
cord-270892-ycc3csyh	405	8	HRV	HRV	NNP
cord-270892-ycc3csyh	405	9	and	and	CC
cord-270892-ycc3csyh	405	10	related	relate	VBN
cord-270892-ycc3csyh	405	11	picornaviruses	picornavirus	NNS
cord-270892-ycc3csyh	405	12	tested	test	VBN
cord-270892-ycc3csyh	405	13	.	.	.
cord-270892-ycc3csyh	406	1	231	231	CD
cord-270892-ycc3csyh	407	1	In	in	IN
cord-270892-ycc3csyh	407	2	a	a	DT
cord-270892-ycc3csyh	407	3	phase	phase	NN
cord-270892-ycc3csyh	407	4	1	1	CD
cord-270892-ycc3csyh	407	5	clinical	clinical	JJ
cord-270892-ycc3csyh	407	6	study	study	NN
cord-270892-ycc3csyh	407	7	,	,	,
cord-270892-ycc3csyh	407	8	compound	compound	NN
cord-270892-ycc3csyh	407	9	1	1	CD
cord-270892-ycc3csyh	407	10	was	be	VBD
cord-270892-ycc3csyh	407	11	shown	show	VBN
cord-270892-ycc3csyh	407	12	to	to	TO
cord-270892-ycc3csyh	407	13	be	be	VB
cord-270892-ycc3csyh	407	14	safe	safe	JJ
cord-270892-ycc3csyh	407	15	and	and	CC
cord-270892-ycc3csyh	407	16	well	well	RB
cord-270892-ycc3csyh	407	17	tolerated	tolerate	VBN
cord-270892-ycc3csyh	407	18	.	.	.
cord-270892-ycc3csyh	408	1	According	accord	VBG
cord-270892-ycc3csyh	408	2	to	to	IN
cord-270892-ycc3csyh	408	3	a	a	DT
cord-270892-ycc3csyh	408	4	publication	publication	NN
cord-270892-ycc3csyh	408	5	of	of	IN
cord-270892-ycc3csyh	408	6	Patick	Patick	NNP
cord-270892-ycc3csyh	408	7	,	,	,
cord-270892-ycc3csyh	408	8	no	no	DT
cord-270892-ycc3csyh	408	9	further	further	JJ
cord-270892-ycc3csyh	408	10	clinical	clinical	JJ
cord-270892-ycc3csyh	408	11	development	development	NN
cord-270892-ycc3csyh	408	12	was	be	VBD
cord-270892-ycc3csyh	408	13	planned	plan	VBN
cord-270892-ycc3csyh	408	14	for	for	IN
cord-270892-ycc3csyh	408	15	this	this	DT
cord-270892-ycc3csyh	408	16	compound	compound	NN
cord-270892-ycc3csyh	408	17	.	.	.
cord-270892-ycc3csyh	409	1	95	95	CD
cord-270892-ycc3csyh	409	2	 	 	_SP
cord-270892-ycc3csyh	410	1	The	the	DT
cord-270892-ycc3csyh	410	2	blocking	blocking	NN
cord-270892-ycc3csyh	410	3	of	of	IN
cord-270892-ycc3csyh	410	4	viral	viral	JJ
cord-270892-ycc3csyh	410	5	RNA	RNA	NNP
cord-270892-ycc3csyh	410	6	synthesis	synthesis	NN
cord-270892-ycc3csyh	410	7	during	during	IN
cord-270892-ycc3csyh	410	8	replication	replication	NN
cord-270892-ycc3csyh	410	9	represents	represent	VBZ
cord-270892-ycc3csyh	410	10	another	another	DT
cord-270892-ycc3csyh	410	11	site	site	NN
cord-270892-ycc3csyh	410	12	for	for	IN
cord-270892-ycc3csyh	410	13	chemotherapeutic	chemotherapeutic	JJ
cord-270892-ycc3csyh	410	14	interdiction	interdiction	NN
cord-270892-ycc3csyh	410	15	.	.	.
cord-270892-ycc3csyh	411	1	It	-PRON-	PRP
cord-270892-ycc3csyh	411	2	was	be	VBD
cord-270892-ycc3csyh	411	3	shown	show	VBN
cord-270892-ycc3csyh	411	4	that	that	IN
cord-270892-ycc3csyh	411	5	,	,	,
cord-270892-ycc3csyh	411	6	rhinoviral	rhinoviral	NNP
cord-270892-ycc3csyh	411	7	RNA	RNA	NNP
cord-270892-ycc3csyh	411	8	can	can	MD
cord-270892-ycc3csyh	411	9	be	be	VB
cord-270892-ycc3csyh	411	10	targeted	target	VBN
cord-270892-ycc3csyh	411	11	in	in	IN
cord-270892-ycc3csyh	411	12	a	a	DT
cord-270892-ycc3csyh	411	13	sequence	sequence	NN
cord-270892-ycc3csyh	411	14	-	-	HYPH
cord-270892-ycc3csyh	411	15	specific	specific	JJ
cord-270892-ycc3csyh	411	16	manner	manner	NN
cord-270892-ycc3csyh	411	17	by	by	IN
cord-270892-ycc3csyh	411	18	deoxyribozymes	deoxyribozyme	NNS
cord-270892-ycc3csyh	411	19	,	,	,
cord-270892-ycc3csyh	411	20	232	232	CD
cord-270892-ycc3csyh	411	21	morpholino	morpholino	NNP
cord-270892-ycc3csyh	411	22	oligomers	oligomer	NNS
cord-270892-ycc3csyh	411	23	,	,	,
cord-270892-ycc3csyh	411	24	233	233	CD
cord-270892-ycc3csyh	411	25	and	and	CC
cord-270892-ycc3csyh	411	26	small	small	JJ
cord-270892-ycc3csyh	411	27	interfering	interfere	VBG
cord-270892-ycc3csyh	411	28	ribonucleic	ribonucleic	NN
cord-270892-ycc3csyh	411	29	acids	acid	NNS
cord-270892-ycc3csyh	411	30	.	.	.
cord-270892-ycc3csyh	412	1	234	234	CD
cord-270892-ycc3csyh	413	1	The	the	DT
cord-270892-ycc3csyh	413	2	efficacy	efficacy	NN
cord-270892-ycc3csyh	413	3	of	of	IN
cord-270892-ycc3csyh	413	4	the	the	DT
cord-270892-ycc3csyh	413	5	latter	latter	JJ
cord-270892-ycc3csyh	413	6	two	two	CD
cord-270892-ycc3csyh	413	7	approaches	approach	NNS
cord-270892-ycc3csyh	413	8	was	be	VBD
cord-270892-ycc3csyh	413	9	confirmed	confirm	VBN
cord-270892-ycc3csyh	413	10	in	in	IN
cord-270892-ycc3csyh	413	11	cell	cell	NN
cord-270892-ycc3csyh	413	12	culture	culture	NN
cord-270892-ycc3csyh	413	13	.	.	.
cord-270892-ycc3csyh	414	1	In	in	IN
cord-270892-ycc3csyh	414	2	addition	addition	NN
cord-270892-ycc3csyh	414	3	,	,	,
cord-270892-ycc3csyh	414	4	2-furylmercury	2-furylmercury	CD
cord-270892-ycc3csyh	414	5	chloride	chloride	NN
cord-270892-ycc3csyh	414	6	(	(	-LRB-
cord-270892-ycc3csyh	414	7	Fig	Fig	NNP
cord-270892-ycc3csyh	414	8	.	.	NNP
cord-270892-ycc3csyh	414	9	4	4	CD
cord-270892-ycc3csyh	414	10	;	;	:
cord-270892-ycc3csyh	414	11	Table	Table	NNP
cord-270892-ycc3csyh	414	12	II	II	NNP
cord-270892-ycc3csyh	414	13	)	)	-RRB-
cord-270892-ycc3csyh	414	14	,	,	,
cord-270892-ycc3csyh	414	15	235	235	CD
cord-270892-ycc3csyh	414	16	Table	Table	NNP
cord-270892-ycc3csyh	414	17	III	III	NNP
cord-270892-ycc3csyh	414	18	)	)	-RRB-
cord-270892-ycc3csyh	414	19	,	,	,
cord-270892-ycc3csyh	414	20	236	236	CD
cord-270892-ycc3csyh	414	21	and	and	CC
cord-270892-ycc3csyh	414	22	pyrrolidine	pyrrolidine	NNP
cord-270892-ycc3csyh	414	23	dithiocarbamate	dithiocarbamate	NNP
cord-270892-ycc3csyh	414	24	(	(	-LRB-
cord-270892-ycc3csyh	414	25	Fig	Fig	NNP
cord-270892-ycc3csyh	414	26	.	.	NNP
cord-270892-ycc3csyh	414	27	4	4	LS
cord-270892-ycc3csyh	414	28	)	)	-RRB-
cord-270892-ycc3csyh	414	29	interfered	interfere	VBD
cord-270892-ycc3csyh	414	30	with	with	IN
cord-270892-ycc3csyh	414	31	rhinoviral	rhinoviral	NNP
cord-270892-ycc3csyh	414	32	RNA	RNA	NNP
cord-270892-ycc3csyh	414	33	synthesis	synthesis	NN
cord-270892-ycc3csyh	414	34	and	and	CC
cord-270892-ycc3csyh	414	35	inhibited	inhibit	VBD
cord-270892-ycc3csyh	414	36	HRV	HRV	NNP
cord-270892-ycc3csyh	414	37	replication	replication	NN
cord-270892-ycc3csyh	414	38	in	in	IN
cord-270892-ycc3csyh	414	39	cell	cell	NN
cord-270892-ycc3csyh	414	40	culture	culture	NN
cord-270892-ycc3csyh	414	41	-	-	HYPH
cord-270892-ycc3csyh	414	42	based	base	VBN
cord-270892-ycc3csyh	414	43	assays	assay	NNS
cord-270892-ycc3csyh	414	44	.	.	.
cord-270892-ycc3csyh	415	1	206	206	CD
cord-270892-ycc3csyh	415	2	,	,	,
cord-270892-ycc3csyh	415	3	237	237	CD
cord-270892-ycc3csyh	416	1	The	the	DT
cord-270892-ycc3csyh	416	2	nucleoside	nucleoside	NN
cord-270892-ycc3csyh	416	3	analog	analog	NN
cord-270892-ycc3csyh	416	4	ribavirin	ribavirin	NNP
cord-270892-ycc3csyh	417	1	(	(	-LRB-
cord-270892-ycc3csyh	417	2	Fig	Fig	NNP
cord-270892-ycc3csyh	417	3	.	.	NNP
cord-270892-ycc3csyh	417	4	4	4	CD
cord-270892-ycc3csyh	417	5	;	;	:
cord-270892-ycc3csyh	417	6	Table	Table	NNP
cord-270892-ycc3csyh	417	7	II	ii	CD
cord-270892-ycc3csyh	417	8	)	)	-RRB-
cord-270892-ycc3csyh	418	1	that	that	DT
cord-270892-ycc3csyh	418	2	inhibits	inhibit	VBZ
cord-270892-ycc3csyh	418	3	a	a	DT
cord-270892-ycc3csyh	418	4	broad	broad	JJ
cord-270892-ycc3csyh	418	5	spectrum	spectrum	NN
cord-270892-ycc3csyh	418	6	of	of	IN
cord-270892-ycc3csyh	418	7	RNA	RNA	NNP
cord-270892-ycc3csyh	418	8	as	as	RB
cord-270892-ycc3csyh	418	9	well	well	RB
cord-270892-ycc3csyh	418	10	as	as	IN
cord-270892-ycc3csyh	418	11	DNA	dna	NN
cord-270892-ycc3csyh	418	12	viruses	virus	NNS
cord-270892-ycc3csyh	418	13	acts	act	VBZ
cord-270892-ycc3csyh	418	14	also	also	RB
cord-270892-ycc3csyh	418	15	against	against	IN
cord-270892-ycc3csyh	418	16	HRV-2	HRV-2	NNP
cord-270892-ycc3csyh	418	17	in	in	IN
cord-270892-ycc3csyh	418	18	HeLa	HeLa	NNP
cord-270892-ycc3csyh	418	19	cells	cell	NNS
cord-270892-ycc3csyh	418	20	.	.	.
cord-270892-ycc3csyh	419	1	238	238	CD
cord-270892-ycc3csyh	419	2	,	,	,
cord-270892-ycc3csyh	419	3	239	239	CD
cord-270892-ycc3csyh	420	1	The	the	DT
cord-270892-ycc3csyh	420	2	cellular	cellular	JJ
cord-270892-ycc3csyh	420	3	inosine	inosine	NN
cord-270892-ycc3csyh	420	4	monophosphate	monophosphate	NN
cord-270892-ycc3csyh	420	5	dehydrogenase	dehydrogenase	NN
cord-270892-ycc3csyh	420	6	that	that	WDT
cord-270892-ycc3csyh	420	7	controls	control	VBZ
cord-270892-ycc3csyh	420	8	de	de	NNP
cord-270892-ycc3csyh	420	9	novo	novo	NNP
cord-270892-ycc3csyh	420	10	synthesis	synthesis	NN
cord-270892-ycc3csyh	420	11	of	of	IN
cord-270892-ycc3csyh	420	12	purine	purine	NNP
cord-270892-ycc3csyh	420	13	nucleosides	nucleosides	NNP
cord-270892-ycc3csyh	420	14	represents	represent	VBZ
cord-270892-ycc3csyh	420	15	the	the	DT
cord-270892-ycc3csyh	420	16	principal	principal	JJ
cord-270892-ycc3csyh	420	17	target	target	NN
cord-270892-ycc3csyh	420	18	in	in	IN
cord-270892-ycc3csyh	420	19	the	the	DT
cord-270892-ycc3csyh	420	20	mode	mode	NN
cord-270892-ycc3csyh	420	21	of	of	IN
cord-270892-ycc3csyh	420	22	action	action	NN
cord-270892-ycc3csyh	420	23	of	of	IN
cord-270892-ycc3csyh	420	24	ribavirin	ribavirin	NN
cord-270892-ycc3csyh	420	25	.	.	.
cord-270892-ycc3csyh	421	1	240	240	CD
cord-270892-ycc3csyh	422	1	Moreover	moreover	RB
cord-270892-ycc3csyh	422	2	,	,	,
cord-270892-ycc3csyh	422	3	when	when	WRB
cord-270892-ycc3csyh	422	4	ribavirin	ribavirin	NN
cord-270892-ycc3csyh	422	5	is	be	VBZ
cord-270892-ycc3csyh	422	6	incorporated	incorporate	VBN
cord-270892-ycc3csyh	422	7	into	into	IN
cord-270892-ycc3csyh	422	8	picornavirus	picornavirus	NNP
cord-270892-ycc3csyh	422	9	RNA	RNA	NNP
cord-270892-ycc3csyh	422	10	,	,	,
cord-270892-ycc3csyh	422	11	it	-PRON-	PRP
cord-270892-ycc3csyh	422	12	pairs	pair	VBZ
cord-270892-ycc3csyh	422	13	equally	equally	RB
cord-270892-ycc3csyh	422	14	well	well	RB
cord-270892-ycc3csyh	422	15	with	with	IN
cord-270892-ycc3csyh	422	16	either	either	CC
cord-270892-ycc3csyh	422	17	uracil	uracil	NN
cord-270892-ycc3csyh	422	18	or	or	CC
cord-270892-ycc3csyh	422	19	cytosine	cytosine	NN
cord-270892-ycc3csyh	422	20	inducing	induce	VBG
cord-270892-ycc3csyh	422	21	mutations	mutation	NNS
cord-270892-ycc3csyh	422	22	that	that	WDT
cord-270892-ycc3csyh	422	23	can	can	MD
cord-270892-ycc3csyh	422	24	be	be	VB
cord-270892-ycc3csyh	422	25	lethal	lethal	JJ
cord-270892-ycc3csyh	422	26	to	to	IN
cord-270892-ycc3csyh	422	27	RNA	RNA	NNP
cord-270892-ycc3csyh	422	28	viruses	virus	NNS
cord-270892-ycc3csyh	422	29	.	.	.
cord-270892-ycc3csyh	423	1	241	241	CD
cord-270892-ycc3csyh	424	1	Further	further	RB
cord-270892-ycc3csyh	424	2	identified	identify	VBN
cord-270892-ycc3csyh	424	3	mechanisms	mechanism	NNS
cord-270892-ycc3csyh	424	4	of	of	IN
cord-270892-ycc3csyh	424	5	action	action	NN
cord-270892-ycc3csyh	424	6	for	for	IN
cord-270892-ycc3csyh	424	7	ribavirin	ribavirin	NNS
cord-270892-ycc3csyh	424	8	include	include	VBP
cord-270892-ycc3csyh	424	9	inhibition	inhibition	NN
cord-270892-ycc3csyh	424	10	of	of	IN
cord-270892-ycc3csyh	424	11	genomic	genomic	JJ
cord-270892-ycc3csyh	424	12	RNA	rna	NN
cord-270892-ycc3csyh	424	13	capping	capping	NN
cord-270892-ycc3csyh	424	14	,	,	,
cord-270892-ycc3csyh	424	15	enhancement	enhancement	NN
cord-270892-ycc3csyh	424	16	of	of	IN
cord-270892-ycc3csyh	424	17	host	host	NN
cord-270892-ycc3csyh	424	18	T	T	NNP
cord-270892-ycc3csyh	424	19	-	-	HYPH
cord-270892-ycc3csyh	424	20	cellmediated	cellmediate	VBN
cord-270892-ycc3csyh	424	21	immunity	immunity	NN
cord-270892-ycc3csyh	424	22	against	against	IN
cord-270892-ycc3csyh	424	23	viral	viral	JJ
cord-270892-ycc3csyh	424	24	infections	infection	NNS
cord-270892-ycc3csyh	424	25	through	through	IN
cord-270892-ycc3csyh	424	26	helping	help	VBG
cord-270892-ycc3csyh	424	27	to	to	TO
cord-270892-ycc3csyh	424	28	switch	switch	VB
cord-270892-ycc3csyh	424	29	the	the	DT
cord-270892-ycc3csyh	424	30	host	host	NN
cord-270892-ycc3csyh	424	31	T	t	NN
cord-270892-ycc3csyh	424	32	-	-	HYPH
cord-270892-ycc3csyh	424	33	cell	cell	NN
cord-270892-ycc3csyh	424	34	phenotype	phenotype	NN
cord-270892-ycc3csyh	424	35	from	from	IN
cord-270892-ycc3csyh	424	36	type	type	NN
cord-270892-ycc3csyh	424	37	2	2	CD
cord-270892-ycc3csyh	424	38	to	to	TO
cord-270892-ycc3csyh	424	39	type	type	VB
cord-270892-ycc3csyh	424	40	1	1	CD
cord-270892-ycc3csyh	424	41	.	.	.
cord-270892-ycc3csyh	424	42	242	242	CD
cord-270892-ycc3csyh	424	43	Another	another	DT
cord-270892-ycc3csyh	424	44	compound	compound	NN
cord-270892-ycc3csyh	424	45	with	with	IN
cord-270892-ycc3csyh	424	46	potent	potent	JJ
cord-270892-ycc3csyh	424	47	anti	anti	JJ
cord-270892-ycc3csyh	424	48	-	-	JJ
cord-270892-ycc3csyh	424	49	HRV	HRV	NNP
cord-270892-ycc3csyh	424	50	activity	activity	NN
cord-270892-ycc3csyh	424	51	in	in	IN
cord-270892-ycc3csyh	424	52	vitro	vitro	FW
cord-270892-ycc3csyh	424	53	is	be	VBZ
cord-270892-ycc3csyh	424	54	enviroxime	enviroxime	JJ
cord-270892-ycc3csyh	424	55	(	(	-LRB-
cord-270892-ycc3csyh	424	56	Fig	Fig	NNP
cord-270892-ycc3csyh	424	57	.	.	NNP
cord-270892-ycc3csyh	424	58	4	4	CD
cord-270892-ycc3csyh	424	59	;	;	:
cord-270892-ycc3csyh	424	60	Table	Table	NNP
cord-270892-ycc3csyh	424	61	II	II	NNP
cord-270892-ycc3csyh	424	62	)	)	-RRB-
cord-270892-ycc3csyh	424	63	,	,	,
cord-270892-ycc3csyh	424	64	a	a	DT
cord-270892-ycc3csyh	424	65	benzimidazole	benzimidazole	NN
cord-270892-ycc3csyh	424	66	derivative	derivative	JJ
cord-270892-ycc3csyh	424	67	.	.	.
cord-270892-ycc3csyh	425	1	243	243	CD
cord-270892-ycc3csyh	425	2	,	,	,
cord-270892-ycc3csyh	425	3	244	244	CD
cord-270892-ycc3csyh	426	1	It	-PRON-	PRP
cord-270892-ycc3csyh	426	2	inhibits	inhibit	VBZ
cord-270892-ycc3csyh	426	3	viral	viral	JJ
cord-270892-ycc3csyh	426	4	plus	plus	CC
cord-270892-ycc3csyh	426	5	strand	strand	NNP
cord-270892-ycc3csyh	426	6	RNA	RNA	NNP
cord-270892-ycc3csyh	426	7	synthesis	synthesis	NN
cord-270892-ycc3csyh	426	8	.	.	.
cord-270892-ycc3csyh	427	1	245	245	CD
cord-270892-ycc3csyh	428	1	In	in	IN
cord-270892-ycc3csyh	428	2	particular	particular	JJ
cord-270892-ycc3csyh	428	3	the	the	DT
cord-270892-ycc3csyh	428	4	3A	3A	NNP
cord-270892-ycc3csyh	428	5	protein	protein	NNP
cord-270892-ycc3csyh	428	6	,	,	,
cord-270892-ycc3csyh	428	7	which	which	WDT
cord-270892-ycc3csyh	428	8	is	be	VBZ
cord-270892-ycc3csyh	428	9	involved	involve	VBN
cord-270892-ycc3csyh	428	10	in	in	IN
cord-270892-ycc3csyh	428	11	the	the	DT
cord-270892-ycc3csyh	428	12	initiation	initiation	NN
cord-270892-ycc3csyh	428	13	of	of	IN
cord-270892-ycc3csyh	428	14	plus	plus	NNP
cord-270892-ycc3csyh	428	15	strand	strand	NNP
cord-270892-ycc3csyh	428	16	RNA	RNA	NNP
cord-270892-ycc3csyh	428	17	synthesis	synthesis	NN
cord-270892-ycc3csyh	428	18	,	,	,
cord-270892-ycc3csyh	428	19	was	be	VBD
cord-270892-ycc3csyh	428	20	implicated	implicate	VBN
cord-270892-ycc3csyh	428	21	as	as	IN
cord-270892-ycc3csyh	428	22	likely	likely	JJ
cord-270892-ycc3csyh	428	23	target	target	NN
cord-270892-ycc3csyh	428	24	of	of	IN
cord-270892-ycc3csyh	428	25	drug	drug	NN
cord-270892-ycc3csyh	428	26	activity	activity	NN
cord-270892-ycc3csyh	428	27	.	.	.
cord-270892-ycc3csyh	429	1	246	246	CD
cord-270892-ycc3csyh	429	2	,	,	,
cord-270892-ycc3csyh	429	3	247	247	CD
cord-270892-ycc3csyh	429	4	However	however	RB
cord-270892-ycc3csyh	429	5	,	,	,
cord-270892-ycc3csyh	429	6	results	result	VBZ
cord-270892-ycc3csyh	429	7	from	from	IN
cord-270892-ycc3csyh	429	8	another	another	DT
cord-270892-ycc3csyh	429	9	study	study	NN
cord-270892-ycc3csyh	429	10	suggest	suggest	VBP
cord-270892-ycc3csyh	429	11	that	that	IN
cord-270892-ycc3csyh	429	12	enviroxime	enviroxime	NNP
cord-270892-ycc3csyh	429	13	targets	target	VBZ
cord-270892-ycc3csyh	429	14	a	a	DT
cord-270892-ycc3csyh	429	15	complex	complex	NN
cord-270892-ycc3csyh	429	16	of	of	IN
cord-270892-ycc3csyh	429	17	proteins	protein	NNS
cord-270892-ycc3csyh	429	18	and/or	and/or	CC
cord-270892-ycc3csyh	429	19	cellular	cellular	JJ
cord-270892-ycc3csyh	429	20	factors	factor	NNS
cord-270892-ycc3csyh	429	21	and	and	CC
cord-270892-ycc3csyh	429	22	that	that	IN
cord-270892-ycc3csyh	429	23	the	the	DT
cord-270892-ycc3csyh	429	24	exact	exact	JJ
cord-270892-ycc3csyh	429	25	mechanism	mechanism	NN
cord-270892-ycc3csyh	429	26	remains	remain	VBZ
cord-270892-ycc3csyh	429	27	to	to	TO
cord-270892-ycc3csyh	429	28	be	be	VB
cord-270892-ycc3csyh	429	29	studied	study	VBN
cord-270892-ycc3csyh	429	30	.	.	.
cord-270892-ycc3csyh	430	1	248	248	CD
cord-270892-ycc3csyh	431	1	Although	although	IN
cord-270892-ycc3csyh	431	2	there	there	EX
cord-270892-ycc3csyh	431	3	was	be	VBD
cord-270892-ycc3csyh	431	4	a	a	DT
cord-270892-ycc3csyh	431	5	statistically	statistically	RB
cord-270892-ycc3csyh	431	6	significant	significant	JJ
cord-270892-ycc3csyh	431	7	reduction	reduction	NN
cord-270892-ycc3csyh	431	8	in	in	IN
cord-270892-ycc3csyh	431	9	clinical	clinical	JJ
cord-270892-ycc3csyh	431	10	score	score	NN
cord-270892-ycc3csyh	431	11	in	in	IN
cord-270892-ycc3csyh	431	12	a	a	DT
cord-270892-ycc3csyh	431	13	prophylactic	prophylactic	JJ
cord-270892-ycc3csyh	431	14	study	study	NN
cord-270892-ycc3csyh	431	15	with	with	IN
cord-270892-ycc3csyh	431	16	HRV-9-infected	hrv-9-infecte	VBN
cord-270892-ycc3csyh	431	17	volunteers	volunteer	NNS
cord-270892-ycc3csyh	431	18	,	,	,
cord-270892-ycc3csyh	431	19	152	152	CD
cord-270892-ycc3csyh	431	20	enviroxime	enviroxime	NN
cord-270892-ycc3csyh	431	21	failed	fail	VBD
cord-270892-ycc3csyh	431	22	in	in	IN
cord-270892-ycc3csyh	431	23	experimentally	experimentally	RB
cord-270892-ycc3csyh	431	24	induced	induce	VBN
cord-270892-ycc3csyh	431	25	HRV-4	HRV-4	NNP
cord-270892-ycc3csyh	431	26	and	and	CC
cord-270892-ycc3csyh	431	27	HRV-39	HRV-39	NNP
cord-270892-ycc3csyh	431	28	infection	infection	NN
cord-270892-ycc3csyh	431	29	,	,	,
cord-270892-ycc3csyh	431	30	149	149	CD
cord-270892-ycc3csyh	431	31	,	,	,
cord-270892-ycc3csyh	431	32	151	151	CD
cord-270892-ycc3csyh	431	33	and	and	CC
cord-270892-ycc3csyh	431	34	in	in	IN
cord-270892-ycc3csyh	431	35	clinical	clinical	JJ
cord-270892-ycc3csyh	431	36	studies	study	NNS
cord-270892-ycc3csyh	431	37	,	,	,
cord-270892-ycc3csyh	431	38	248	248	CD
cord-270892-ycc3csyh	431	39	-	-	SYM
cord-270892-ycc3csyh	431	40	250	250	CD
cord-270892-ycc3csyh	431	41	because	because	IN
cord-270892-ycc3csyh	431	42	of	of	IN
cord-270892-ycc3csyh	431	43	poor	poor	JJ
cord-270892-ycc3csyh	431	44	bioavailability	bioavailability	NN
cord-270892-ycc3csyh	431	45	and	and	CC
cord-270892-ycc3csyh	431	46	side	side	NN
cord-270892-ycc3csyh	431	47	effects	effect	NNS
cord-270892-ycc3csyh	431	48	.	.	.
cord-270892-ycc3csyh	432	1	In	in	IN
cord-270892-ycc3csyh	432	2	an	an	DT
cord-270892-ycc3csyh	432	3	attempt	attempt	NN
cord-270892-ycc3csyh	432	4	to	to	TO
cord-270892-ycc3csyh	432	5	overcome	overcome	VB
cord-270892-ycc3csyh	432	6	the	the	DT
cord-270892-ycc3csyh	432	7	marked	marked	JJ
cord-270892-ycc3csyh	432	8	hydrophobicity	hydrophobicity	NN
cord-270892-ycc3csyh	432	9	,	,	,
cord-270892-ycc3csyh	432	10	water	water	NN
cord-270892-ycc3csyh	432	11	insolubility	insolubility	NN
cord-270892-ycc3csyh	432	12	,	,	,
cord-270892-ycc3csyh	432	13	and	and	CC
cord-270892-ycc3csyh	432	14	toxicity	toxicity	NN
cord-270892-ycc3csyh	432	15	,	,	,
cord-270892-ycc3csyh	432	16	Wyde	Wyde	NNP
cord-270892-ycc3csyh	432	17	et	et	NNP
cord-270892-ycc3csyh	432	18	al	al	NNP
cord-270892-ycc3csyh	432	19	.	.	.
cord-270892-ycc3csyh	433	1	incorporated	incorporate	VBN
cord-270892-ycc3csyh	433	2	enviroxime	enviroxime	NN
cord-270892-ycc3csyh	433	3	into	into	IN
cord-270892-ycc3csyh	433	4	liposomes	liposome	NNS
cord-270892-ycc3csyh	433	5	and	and	CC
cord-270892-ycc3csyh	433	6	then	then	RB
cord-270892-ycc3csyh	433	7	tested	test	VBD
cord-270892-ycc3csyh	433	8	the	the	DT
cord-270892-ycc3csyh	433	9	anti	anti	JJ
cord-270892-ycc3csyh	433	10	-	-	JJ
cord-270892-ycc3csyh	433	11	HRV	HRV	NNP
cord-270892-ycc3csyh	433	12	activity	activity	NN
cord-270892-ycc3csyh	433	13	and	and	CC
cord-270892-ycc3csyh	433	14	toxicity	toxicity	NN
cord-270892-ycc3csyh	433	15	of	of	IN
cord-270892-ycc3csyh	433	16	the	the	DT
cord-270892-ycc3csyh	433	17	liposome	liposome	NN
cord-270892-ycc3csyh	433	18	-	-	HYPH
cord-270892-ycc3csyh	433	19	incorporated	incorporate	VBN
cord-270892-ycc3csyh	433	20	enviroxime	enviroxime	NN
cord-270892-ycc3csyh	433	21	in	in	IN
cord-270892-ycc3csyh	433	22	cell	cell	NN
cord-270892-ycc3csyh	433	23	culture	culture	NN
cord-270892-ycc3csyh	433	24	.	.	.
cord-270892-ycc3csyh	434	1	251	251	CD
cord-270892-ycc3csyh	435	1	The	the	DT
cord-270892-ycc3csyh	435	2	liposome	liposome	NN
cord-270892-ycc3csyh	435	3	preparation	preparation	NN
cord-270892-ycc3csyh	435	4	of	of	IN
cord-270892-ycc3csyh	435	5	enviroxime	enviroxime	NN
cord-270892-ycc3csyh	435	6	inhibited	inhibit	VBN
cord-270892-ycc3csyh	435	7	HRV-1A	HRV-1A	NNP
cord-270892-ycc3csyh	435	8	and	and	CC
cord-270892-ycc3csyh	435	9	HRV13	HRV13	NNP
cord-270892-ycc3csyh	435	10	as	as	RB
cord-270892-ycc3csyh	435	11	effective	effective	JJ
cord-270892-ycc3csyh	435	12	as	as	IN
cord-270892-ycc3csyh	435	13	the	the	DT
cord-270892-ycc3csyh	435	14	parent	parent	NN
cord-270892-ycc3csyh	435	15	compound	compound	NN
cord-270892-ycc3csyh	435	16	and	and	CC
cord-270892-ycc3csyh	435	17	was	be	VBD
cord-270892-ycc3csyh	435	18	10-to	10-to	CD
cord-270892-ycc3csyh	436	1	Z50-fold	Z50-fold	NNP
cord-270892-ycc3csyh	436	2	less	less	RBR
cord-270892-ycc3csyh	436	3	toxic	toxic	JJ
cord-270892-ycc3csyh	436	4	.	.	.
cord-270892-ycc3csyh	437	1	In	in	IN
cord-270892-ycc3csyh	437	2	contrast	contrast	NN
cord-270892-ycc3csyh	437	3	to	to	IN
cord-270892-ycc3csyh	437	4	free	free	JJ
cord-270892-ycc3csyh	437	5	enviroxime	enviroxime	NN
cord-270892-ycc3csyh	437	6	,	,	,
cord-270892-ycc3csyh	437	7	the	the	DT
cord-270892-ycc3csyh	437	8	liposome	liposome	NN
cord-270892-ycc3csyh	437	9	preparation	preparation	NN
cord-270892-ycc3csyh	437	10	was	be	VBD
cord-270892-ycc3csyh	437	11	readily	readily	RB
cord-270892-ycc3csyh	437	12	and	and	CC
cord-270892-ycc3csyh	437	13	successfully	successfully	RB
cord-270892-ycc3csyh	437	14	delivered	deliver	VBN
cord-270892-ycc3csyh	437	15	by	by	IN
cord-270892-ycc3csyh	437	16	small	small	JJ
cord-270892-ycc3csyh	437	17	-	-	HYPH
cord-270892-ycc3csyh	437	18	particle	particle	NN
cord-270892-ycc3csyh	437	19	aerosol	aerosol	NN
cord-270892-ycc3csyh	437	20	to	to	IN
cord-270892-ycc3csyh	437	21	the	the	DT
cord-270892-ycc3csyh	437	22	upper	upper	JJ
cord-270892-ycc3csyh	437	23	and	and	CC
cord-270892-ycc3csyh	437	24	lower	low	JJR
cord-270892-ycc3csyh	437	25	respiratory	respiratory	JJ
cord-270892-ycc3csyh	437	26	tract	tract	NN
cord-270892-ycc3csyh	437	27	of	of	IN
cord-270892-ycc3csyh	437	28	mice	mouse	NNS
cord-270892-ycc3csyh	437	29	.	.	.
cord-270892-ycc3csyh	438	1	In	in	IN
cord-270892-ycc3csyh	438	2	another	another	DT
cord-270892-ycc3csyh	438	3	attempt	attempt	NN
cord-270892-ycc3csyh	438	4	to	to	TO
cord-270892-ycc3csyh	438	5	overcome	overcome	VB
cord-270892-ycc3csyh	438	6	the	the	DT
cord-270892-ycc3csyh	438	7	disadvantages	disadvantage	NNS
cord-270892-ycc3csyh	438	8	of	of	IN
cord-270892-ycc3csyh	438	9	enviroxime	enviroxime	NN
cord-270892-ycc3csyh	438	10	,	,	,
cord-270892-ycc3csyh	438	11	several	several	JJ
cord-270892-ycc3csyh	438	12	benzimidazole	benzimidazole	NNS
cord-270892-ycc3csyh	438	13	as	as	RB
cord-270892-ycc3csyh	438	14	well	well	RB
cord-270892-ycc3csyh	438	15	as	as	IN
cord-270892-ycc3csyh	438	16	nonbenzimidazole	nonbenzimidazole	NNP
cord-270892-ycc3csyh	438	17	analogs	analog	NNS
cord-270892-ycc3csyh	438	18	were	be	VBD
cord-270892-ycc3csyh	438	19	synthesized	synthesize	VBN
cord-270892-ycc3csyh	438	20	and	and	CC
cord-270892-ycc3csyh	438	21	studied	study	VBN
cord-270892-ycc3csyh	438	22	.	.	.
cord-270892-ycc3csyh	439	1	[	[	-LRB-
cord-270892-ycc3csyh	439	2	252	252	CD
cord-270892-ycc3csyh	439	3	]	]	-RRB-
cord-270892-ycc3csyh	439	4	[	[	-LRB-
cord-270892-ycc3csyh	439	5	253	253	CD
cord-270892-ycc3csyh	439	6	]	]	-RRB-
cord-270892-ycc3csyh	440	1	[	[	-LRB-
cord-270892-ycc3csyh	440	2	254	254	CD
cord-270892-ycc3csyh	440	3	]	]	-RRB-
cord-270892-ycc3csyh	440	4	[	[	-LRB-
cord-270892-ycc3csyh	440	5	255	255	CD
cord-270892-ycc3csyh	440	6	]	]	-RRB-
cord-270892-ycc3csyh	440	7	Even	even	RB
cord-270892-ycc3csyh	440	8	though	though	IN
cord-270892-ycc3csyh	440	9	some	some	DT
cord-270892-ycc3csyh	440	10	compounds	compound	NNS
cord-270892-ycc3csyh	440	11	were	be	VBD
cord-270892-ycc3csyh	440	12	better	well	RBR
cord-270892-ycc3csyh	440	13	bioavailable	bioavailable	JJ
cord-270892-ycc3csyh	440	14	and	and	CC
cord-270892-ycc3csyh	440	15	could	could	MD
cord-270892-ycc3csyh	440	16	be	be	VB
cord-270892-ycc3csyh	440	17	administered	administer	VBN
cord-270892-ycc3csyh	440	18	orally	orally	RB
cord-270892-ycc3csyh	440	19	,	,	,
cord-270892-ycc3csyh	440	20	254	254	CD
cord-270892-ycc3csyh	440	21	none	none	NN
cord-270892-ycc3csyh	440	22	of	of	IN
cord-270892-ycc3csyh	440	23	these	these	DT
cord-270892-ycc3csyh	440	24	compounds	compound	NNS
cord-270892-ycc3csyh	440	25	was	be	VBD
cord-270892-ycc3csyh	440	26	tested	test	VBN
cord-270892-ycc3csyh	440	27	in	in	IN
cord-270892-ycc3csyh	440	28	clinical	clinical	JJ
cord-270892-ycc3csyh	440	29	studies	study	NNS
cord-270892-ycc3csyh	440	30	.	.	.
cord-270892-ycc3csyh	441	1	Besides	besides	IN
cord-270892-ycc3csyh	441	2	virus	virus	NN
cord-270892-ycc3csyh	441	3	-	-	HYPH
cord-270892-ycc3csyh	441	4	specific	specific	JJ
cord-270892-ycc3csyh	441	5	targets	target	NNS
cord-270892-ycc3csyh	441	6	,	,	,
cord-270892-ycc3csyh	441	7	cellular	cellular	JJ
cord-270892-ycc3csyh	441	8	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	441	9	like	like	IN
cord-270892-ycc3csyh	441	10	interferons	interferon	NNS
cord-270892-ycc3csyh	441	11	may	may	MD
cord-270892-ycc3csyh	441	12	represent	represent	VB
cord-270892-ycc3csyh	441	13	a	a	DT
cord-270892-ycc3csyh	441	14	therapeutical	therapeutical	JJ
cord-270892-ycc3csyh	441	15	approach	approach	NN
cord-270892-ycc3csyh	441	16	.	.	.
cord-270892-ycc3csyh	442	1	Among	among	IN
cord-270892-ycc3csyh	442	2	other	other	JJ
cord-270892-ycc3csyh	442	3	activities	activity	NNS
cord-270892-ycc3csyh	442	4	,	,	,
cord-270892-ycc3csyh	442	5	interferons	interferon	NNS
cord-270892-ycc3csyh	442	6	exhibit	exhibit	VBP
cord-270892-ycc3csyh	442	7	antiviral	antiviral	JJ
cord-270892-ycc3csyh	442	8	activity	activity	NN
cord-270892-ycc3csyh	442	9	.	.	.
cord-270892-ycc3csyh	443	1	The	the	DT
cord-270892-ycc3csyh	443	2	advantages	advantage	NNS
cord-270892-ycc3csyh	443	3	of	of	IN
cord-270892-ycc3csyh	443	4	interferon	interferon	NN
cord-270892-ycc3csyh	443	5	application	application	NN
cord-270892-ycc3csyh	443	6	include	include	VBP
cord-270892-ycc3csyh	443	7	the	the	DT
cord-270892-ycc3csyh	443	8	broad	broad	JJ
cord-270892-ycc3csyh	443	9	spectrum	spectrum	NN
cord-270892-ycc3csyh	443	10	of	of	IN
cord-270892-ycc3csyh	443	11	activity	activity	NN
cord-270892-ycc3csyh	443	12	and	and	CC
cord-270892-ycc3csyh	443	13	low	low	JJ
cord-270892-ycc3csyh	443	14	risk	risk	NN
cord-270892-ycc3csyh	443	15	of	of	IN
cord-270892-ycc3csyh	443	16	resistance	resistance	NN
cord-270892-ycc3csyh	443	17	development	development	NN
cord-270892-ycc3csyh	443	18	.	.	.
cord-270892-ycc3csyh	444	1	Human	human	JJ
cord-270892-ycc3csyh	444	2	leukocyte	leukocyte	NN
cord-270892-ycc3csyh	444	3	and	and	CC
cord-270892-ycc3csyh	444	4	fibroblast	fibroblast	NN
cord-270892-ycc3csyh	444	5	as	as	RB
cord-270892-ycc3csyh	444	6	well	well	RB
cord-270892-ycc3csyh	444	7	as	as	IN
cord-270892-ycc3csyh	444	8	recombinant	recombinant	JJ
cord-270892-ycc3csyh	444	9	human	human	NN
cord-270892-ycc3csyh	444	10	a	a	DT
cord-270892-ycc3csyh	444	11	interferons	interferon	NNS
cord-270892-ycc3csyh	444	12	prevent	prevent	VBP
cord-270892-ycc3csyh	444	13	the	the	DT
cord-270892-ycc3csyh	444	14	HRV	HRV	NNP
cord-270892-ycc3csyh	444	15	-	-	HYPH
cord-270892-ycc3csyh	444	16	induced	induce	VBN
cord-270892-ycc3csyh	444	17	CPE	CPE	NNP
cord-270892-ycc3csyh	444	18	in	in	IN
cord-270892-ycc3csyh	444	19	cell	cell	NN
cord-270892-ycc3csyh	444	20	culture	culture	NN
cord-270892-ycc3csyh	444	21	whereas	whereas	IN
cord-270892-ycc3csyh	444	22	a	a	DT
cord-270892-ycc3csyh	444	23	variation	variation	NN
cord-270892-ycc3csyh	444	24	in	in	IN
cord-270892-ycc3csyh	444	25	sensitivity	sensitivity	NN
cord-270892-ycc3csyh	444	26	was	be	VBD
cord-270892-ycc3csyh	444	27	observed	observe	VBN
cord-270892-ycc3csyh	444	28	.	.	.
cord-270892-ycc3csyh	445	1	[	[	-LRB-
cord-270892-ycc3csyh	445	2	256	256	CD
cord-270892-ycc3csyh	445	3	]	]	-RRB-
cord-270892-ycc3csyh	445	4	[	[	-LRB-
cord-270892-ycc3csyh	445	5	257	257	CD
cord-270892-ycc3csyh	445	6	]	]	-RRB-
cord-270892-ycc3csyh	445	7	[	[	-LRB-
cord-270892-ycc3csyh	445	8	258	258	CD
cord-270892-ycc3csyh	445	9	]	]	-RRB-
cord-270892-ycc3csyh	446	1	Intranasally	intranasally	RB
cord-270892-ycc3csyh	446	2	applied	apply	VBN
cord-270892-ycc3csyh	446	3	recombinant	recombinant	JJ
cord-270892-ycc3csyh	446	4	interferon	interferon	NN
cord-270892-ycc3csyh	447	1	a	a	LS
cord-270892-ycc3csyh	447	2	and	and	CC
cord-270892-ycc3csyh	447	3	interferon	interferon	NN
cord-270892-ycc3csyh	447	4	b	b	NN
cord-270892-ycc3csyh	447	5	have	have	VBP
cord-270892-ycc3csyh	447	6	been	be	VBN
cord-270892-ycc3csyh	447	7	shown	show	VBN
cord-270892-ycc3csyh	447	8	to	to	TO
cord-270892-ycc3csyh	447	9	be	be	VB
cord-270892-ycc3csyh	447	10	effective	effective	JJ
cord-270892-ycc3csyh	447	11	in	in	IN
cord-270892-ycc3csyh	447	12	humans	human	NNS
cord-270892-ycc3csyh	447	13	when	when	WRB
cord-270892-ycc3csyh	447	14	provided	provide	VBN
cord-270892-ycc3csyh	447	15	prophylactically	prophylactically	RB
cord-270892-ycc3csyh	447	16	both	both	DT
cord-270892-ycc3csyh	447	17	in	in	IN
cord-270892-ycc3csyh	447	18	experimental	experimental	JJ
cord-270892-ycc3csyh	447	19	and	and	CC
cord-270892-ycc3csyh	447	20	natural	natural	JJ
cord-270892-ycc3csyh	447	21	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	447	22	colds	cold	NNS
cord-270892-ycc3csyh	447	23	.	.	.
cord-270892-ycc3csyh	448	1	[	[	-LRB-
cord-270892-ycc3csyh	448	2	259	259	CD
cord-270892-ycc3csyh	448	3	]	]	-RRB-
cord-270892-ycc3csyh	448	4	[	[	-LRB-
cord-270892-ycc3csyh	448	5	260	260	CD
cord-270892-ycc3csyh	448	6	]	]	-RRB-
cord-270892-ycc3csyh	448	7	[	[	-LRB-
cord-270892-ycc3csyh	448	8	261	261	CD
cord-270892-ycc3csyh	448	9	]	]	-RRB-
cord-270892-ycc3csyh	448	10	[	[	-LRB-
cord-270892-ycc3csyh	448	11	262	262	CD
cord-270892-ycc3csyh	448	12	]	]	-RRB-
cord-270892-ycc3csyh	448	13	[	[	-LRB-
cord-270892-ycc3csyh	448	14	263	263	CD
cord-270892-ycc3csyh	448	15	]	]	-RRB-
cord-270892-ycc3csyh	448	16	[	[	-LRB-
cord-270892-ycc3csyh	448	17	264	264	CD
cord-270892-ycc3csyh	448	18	]	]	-RRB-
cord-270892-ycc3csyh	448	19	Significant	significant	JJ
cord-270892-ycc3csyh	448	20	reductions	reduction	NNS
cord-270892-ycc3csyh	448	21	in	in	IN
cord-270892-ycc3csyh	448	22	illness	illness	NN
cord-270892-ycc3csyh	448	23	frequency	frequency	NN
cord-270892-ycc3csyh	448	24	,	,	,
cord-270892-ycc3csyh	448	25	mean	mean	JJ
cord-270892-ycc3csyh	448	26	symptom	symptom	NN
cord-270892-ycc3csyh	448	27	score	score	NN
cord-270892-ycc3csyh	448	28	,	,	,
cord-270892-ycc3csyh	448	29	nasal	nasal	JJ
cord-270892-ycc3csyh	448	30	secretion	secretion	NN
cord-270892-ycc3csyh	448	31	weights	weight	NNS
cord-270892-ycc3csyh	448	32	,	,	,
cord-270892-ycc3csyh	448	33	and	and	CC
cord-270892-ycc3csyh	448	34	frequency	frequency	NN
cord-270892-ycc3csyh	448	35	of	of	IN
cord-270892-ycc3csyh	448	36	virus	virus	NN
cord-270892-ycc3csyh	448	37	isolation	isolation	NN
cord-270892-ycc3csyh	448	38	were	be	VBD
cord-270892-ycc3csyh	448	39	observed	observe	VBN
cord-270892-ycc3csyh	448	40	.	.	.
cord-270892-ycc3csyh	449	1	In	in	IN
cord-270892-ycc3csyh	449	2	contrast	contrast	NN
cord-270892-ycc3csyh	449	3	,	,	,
cord-270892-ycc3csyh	449	4	recombinant	recombinant	JJ
cord-270892-ycc3csyh	449	5	interferon	interferon	NN
cord-270892-ycc3csyh	449	6	g	g	NN
cord-270892-ycc3csyh	449	7	did	do	VBD
cord-270892-ycc3csyh	449	8	not	not	RB
cord-270892-ycc3csyh	449	9	prevent	prevent	VB
cord-270892-ycc3csyh	449	10	HRV	HRV	NNP
cord-270892-ycc3csyh	449	11	infection	infection	NN
cord-270892-ycc3csyh	449	12	or	or	CC
cord-270892-ycc3csyh	449	13	illness	illness	NN
cord-270892-ycc3csyh	449	14	and	and	CC
cord-270892-ycc3csyh	449	15	may	may	MD
cord-270892-ycc3csyh	449	16	enhance	enhance	VB
cord-270892-ycc3csyh	449	17	the	the	DT
cord-270892-ycc3csyh	449	18	symptoms	symptom	NNS
cord-270892-ycc3csyh	449	19	.	.	.
cord-270892-ycc3csyh	450	1	265	265	CD
cord-270892-ycc3csyh	450	2	Little	little	JJ
cord-270892-ycc3csyh	450	3	to	to	IN
cord-270892-ycc3csyh	450	4	no	no	DT
cord-270892-ycc3csyh	450	5	therapeutic	therapeutic	JJ
cord-270892-ycc3csyh	450	6	effect	effect	NN
cord-270892-ycc3csyh	450	7	was	be	VBD
cord-270892-ycc3csyh	450	8	found	find	VBN
cord-270892-ycc3csyh	450	9	in	in	IN
cord-270892-ycc3csyh	450	10	patients	patient	NNS
cord-270892-ycc3csyh	450	11	with	with	IN
cord-270892-ycc3csyh	450	12	common	common	JJ
cord-270892-ycc3csyh	450	13	cold	cold	NN
cord-270892-ycc3csyh	450	14	after	after	IN
cord-270892-ycc3csyh	450	15	interferon	interferon	NN
cord-270892-ycc3csyh	450	16	treatment	treatment	NN
cord-270892-ycc3csyh	450	17	.	.	.
cord-270892-ycc3csyh	451	1	150	150	CD
cord-270892-ycc3csyh	451	2	,	,	,
cord-270892-ycc3csyh	451	3	266	266	CD
cord-270892-ycc3csyh	452	1	Moreover	moreover	RB
cord-270892-ycc3csyh	452	2	,	,	,
cord-270892-ycc3csyh	452	3	blood	blood	NN
cord-270892-ycc3csyh	452	4	-	-	HYPH
cord-270892-ycc3csyh	452	5	tinged	tinge	VBN
cord-270892-ycc3csyh	452	6	mucus	mucus	NN
cord-270892-ycc3csyh	452	7	and	and	CC
cord-270892-ycc3csyh	452	8	nasal	nasal	NN
cord-270892-ycc3csyh	452	9	bleeding	bleeding	NN
cord-270892-ycc3csyh	452	10	were	be	VBD
cord-270892-ycc3csyh	452	11	described	describe	VBN
cord-270892-ycc3csyh	452	12	as	as	IN
cord-270892-ycc3csyh	452	13	side	side	NN
cord-270892-ycc3csyh	452	14	effects	effect	NNS
cord-270892-ycc3csyh	452	15	.	.	.
cord-270892-ycc3csyh	453	1	263	263	CD
cord-270892-ycc3csyh	453	2	,	,	,
cord-270892-ycc3csyh	453	3	267	267	CD
cord-270892-ycc3csyh	453	4	Combining	combining	NN
cord-270892-ycc3csyh	453	5	interferons	interferon	NNS
cord-270892-ycc3csyh	453	6	with	with	IN
cord-270892-ycc3csyh	453	7	dichloroflavan	dichloroflavan	NNP
cord-270892-ycc3csyh	453	8	,	,	,
cord-270892-ycc3csyh	453	9	enviroxime	enviroxime	NNP
cord-270892-ycc3csyh	453	10	,	,	,
cord-270892-ycc3csyh	453	11	chalcone	chalcone	NNP
cord-270892-ycc3csyh	453	12	Ro-09	Ro-09	NNP
cord-270892-ycc3csyh	453	13	-	-	HYPH
cord-270892-ycc3csyh	453	14	0410	0410	CD
cord-270892-ycc3csyh	453	15	produced	produce	VBD
cord-270892-ycc3csyh	453	16	synergistic	synergistic	JJ
cord-270892-ycc3csyh	453	17	increases	increase	NNS
cord-270892-ycc3csyh	453	18	in	in	IN
cord-270892-ycc3csyh	453	19	antiviral	antiviral	JJ
cord-270892-ycc3csyh	453	20	activity	activity	NN
cord-270892-ycc3csyh	453	21	in	in	IN
cord-270892-ycc3csyh	453	22	vitro	vitro	FW
cord-270892-ycc3csyh	453	23	against	against	IN
cord-270892-ycc3csyh	453	24	HRV-2	HRV-2	NNP
cord-270892-ycc3csyh	453	25	and	and	CC
cord-270892-ycc3csyh	453	26	HRV-9	HRV-9	NNP
cord-270892-ycc3csyh	453	27	.	.	.
cord-270892-ycc3csyh	454	1	268	268	CD
cord-270892-ycc3csyh	455	1	An	an	DT
cord-270892-ycc3csyh	455	2	attempt	attempt	NN
cord-270892-ycc3csyh	455	3	to	to	TO
cord-270892-ycc3csyh	455	4	demonstrate	demonstrate	VB
cord-270892-ycc3csyh	455	5	synergy	synergy	NN
cord-270892-ycc3csyh	455	6	between	between	IN
cord-270892-ycc3csyh	455	7	the	the	DT
cord-270892-ycc3csyh	455	8	anti	anti	JJ
cord-270892-ycc3csyh	455	9	-	-	JJ
cord-270892-ycc3csyh	455	10	HRV	HRV	NNP
cord-270892-ycc3csyh	455	11	effect	effect	NN
cord-270892-ycc3csyh	455	12	of	of	IN
cord-270892-ycc3csyh	455	13	recombinant	recombinant	JJ
cord-270892-ycc3csyh	455	14	human	human	NN
cord-270892-ycc3csyh	455	15	rHuIFN	rHuIFN	NNP
cord-270892-ycc3csyh	455	16	a	a	NNP
cord-270892-ycc3csyh	455	17	and	and	CC
cord-270892-ycc3csyh	455	18	enviroxime	enviroxime	NN
cord-270892-ycc3csyh	455	19	in	in	IN
cord-270892-ycc3csyh	455	20	HRV-9	HRV-9	NNP
cord-270892-ycc3csyh	455	21	and	and	CC
cord-270892-ycc3csyh	455	22	HRV-14-infected	hrv-14-infected	JJ
cord-270892-ycc3csyh	455	23	volunteers	volunteer	NNS
cord-270892-ycc3csyh	455	24	failed	fail	VBD
cord-270892-ycc3csyh	455	25	.	.	.
cord-270892-ycc3csyh	456	1	269	269	CD
cord-270892-ycc3csyh	457	1	According	accord	VBG
cord-270892-ycc3csyh	457	2	to	to	IN
cord-270892-ycc3csyh	457	3	the	the	DT
cord-270892-ycc3csyh	457	4	authors	author	NNS
cord-270892-ycc3csyh	457	5	,	,	,
cord-270892-ycc3csyh	457	6	the	the	DT
cord-270892-ycc3csyh	457	7	main	main	JJ
cord-270892-ycc3csyh	457	8	reason	reason	NN
cord-270892-ycc3csyh	457	9	for	for	IN
cord-270892-ycc3csyh	457	10	this	this	DT
cord-270892-ycc3csyh	457	11	failure	failure	NN
cord-270892-ycc3csyh	457	12	may	may	MD
cord-270892-ycc3csyh	457	13	be	be	VB
cord-270892-ycc3csyh	457	14	the	the	DT
cord-270892-ycc3csyh	457	15	rapid	rapid	JJ
cord-270892-ycc3csyh	457	16	removal	removal	NN
cord-270892-ycc3csyh	457	17	of	of	IN
cord-270892-ycc3csyh	457	18	enviroxime	enviroxime	NN
cord-270892-ycc3csyh	457	19	from	from	IN
cord-270892-ycc3csyh	457	20	the	the	DT
cord-270892-ycc3csyh	457	21	nose	nose	NN
cord-270892-ycc3csyh	457	22	when	when	WRB
cord-270892-ycc3csyh	457	23	given	give	VBN
cord-270892-ycc3csyh	457	24	intranasally	intranasally	RB
cord-270892-ycc3csyh	457	25	.	.	.
cord-270892-ycc3csyh	458	1	A.	A.	NNP
cord-270892-ycc3csyh	458	2	Impact	Impact	NNP
cord-270892-ycc3csyh	458	3	of	of	IN
cord-270892-ycc3csyh	458	4	Natural	Natural	NNP
cord-270892-ycc3csyh	458	5	Products	Products	NNPS
cord-270892-ycc3csyh	458	6	Nature	Nature	NNP
cord-270892-ycc3csyh	458	7	provides	provide	VBZ
cord-270892-ycc3csyh	458	8	an	an	DT
cord-270892-ycc3csyh	458	9	astonishing	astonishing	JJ
cord-270892-ycc3csyh	458	10	pool	pool	NN
cord-270892-ycc3csyh	458	11	of	of	IN
cord-270892-ycc3csyh	458	12	secondary	secondary	JJ
cord-270892-ycc3csyh	458	13	metabolites	metabolite	NNS
cord-270892-ycc3csyh	458	14	biosynthesized	biosynthesize	VBN
cord-270892-ycc3csyh	458	15	from	from	IN
cord-270892-ycc3csyh	458	16	living	live	VBG
cord-270892-ycc3csyh	458	17	organisms	organism	NNS
cord-270892-ycc3csyh	458	18	such	such	JJ
cord-270892-ycc3csyh	458	19	as	as	IN
cord-270892-ycc3csyh	458	20	plants	plant	NNS
cord-270892-ycc3csyh	458	21	,	,	,
cord-270892-ycc3csyh	458	22	fungi	fungus	NNS
cord-270892-ycc3csyh	458	23	,	,	,
cord-270892-ycc3csyh	458	24	protozoan	protozoan	NN
cord-270892-ycc3csyh	458	25	,	,	,
cord-270892-ycc3csyh	458	26	insects	insect	NNS
cord-270892-ycc3csyh	458	27	,	,	,
cord-270892-ycc3csyh	458	28	and	and	CC
cord-270892-ycc3csyh	458	29	other	other	JJ
cord-270892-ycc3csyh	458	30	animal	animal	NN
cord-270892-ycc3csyh	458	31	sources	source	NNS
cord-270892-ycc3csyh	458	32	.	.	.
cord-270892-ycc3csyh	459	1	In	in	IN
cord-270892-ycc3csyh	459	2	contrast	contrast	NN
cord-270892-ycc3csyh	459	3	to	to	IN
cord-270892-ycc3csyh	459	4	synthetic	synthetic	JJ
cord-270892-ycc3csyh	459	5	compounds	compound	NNS
cord-270892-ycc3csyh	459	6	,	,	,
cord-270892-ycc3csyh	459	7	natural	natural	JJ
cord-270892-ycc3csyh	459	8	products	product	NNS
cord-270892-ycc3csyh	459	9	are	be	VBP
cord-270892-ycc3csyh	459	10	characterized	characterize	VBN
cord-270892-ycc3csyh	459	11	by	by	IN
cord-270892-ycc3csyh	459	12	an	an	DT
cord-270892-ycc3csyh	459	13	overwhelming	overwhelming	JJ
cord-270892-ycc3csyh	459	14	chemical	chemical	NN
cord-270892-ycc3csyh	459	15	diversity	diversity	NN
cord-270892-ycc3csyh	459	16	.	.	.
cord-270892-ycc3csyh	460	1	Previously	previously	RB
cord-270892-ycc3csyh	460	2	,	,	,
cord-270892-ycc3csyh	460	3	the	the	DT
cord-270892-ycc3csyh	460	4	chemical	chemical	NN
cord-270892-ycc3csyh	460	5	diversity	diversity	NN
cord-270892-ycc3csyh	460	6	space	space	NN
cord-270892-ycc3csyh	460	7	between	between	IN
cord-270892-ycc3csyh	460	8	these	these	DT
cord-270892-ycc3csyh	460	9	two	two	CD
cord-270892-ycc3csyh	460	10	groups	group	NNS
cord-270892-ycc3csyh	460	11	was	be	VBD
cord-270892-ycc3csyh	460	12	evaluated	evaluate	VBN
cord-270892-ycc3csyh	460	13	with	with	IN
cord-270892-ycc3csyh	460	14	respect	respect	NN
cord-270892-ycc3csyh	460	15	to	to	IN
cord-270892-ycc3csyh	460	16	drug	drug	NN
cord-270892-ycc3csyh	460	17	substances	substance	NNS
cord-270892-ycc3csyh	460	18	by	by	IN
cord-270892-ycc3csyh	460	19	Feher	Feher	NNP
cord-270892-ycc3csyh	460	20	and	and	CC
cord-270892-ycc3csyh	460	21	Schmidt	Schmidt	NNP
cord-270892-ycc3csyh	460	22	.	.	.
cord-270892-ycc3csyh	461	1	270	270	CD
cord-270892-ycc3csyh	462	1	It	-PRON-	PRP
cord-270892-ycc3csyh	462	2	is	be	VBZ
cord-270892-ycc3csyh	462	3	shown	show	VBN
cord-270892-ycc3csyh	462	4	that	that	IN
cord-270892-ycc3csyh	462	5	combinatorial	combinatorial	JJ
cord-270892-ycc3csyh	462	6	compounds	compound	NNS
cord-270892-ycc3csyh	462	7	densely	densely	RB
cord-270892-ycc3csyh	462	8	populate	populate	VBP
cord-270892-ycc3csyh	462	9	a	a	DT
cord-270892-ycc3csyh	462	10	small	small	JJ
cord-270892-ycc3csyh	462	11	area	area	NN
cord-270892-ycc3csyh	462	12	,	,	,
cord-270892-ycc3csyh	462	13	whereas	whereas	IN
cord-270892-ycc3csyh	462	14	natural	natural	JJ
cord-270892-ycc3csyh	462	15	products	product	NNS
cord-270892-ycc3csyh	462	16	cover	cover	VBP
cord-270892-ycc3csyh	462	17	a	a	DT
cord-270892-ycc3csyh	462	18	wider	wide	JJR
cord-270892-ycc3csyh	462	19	range	range	NN
cord-270892-ycc3csyh	462	20	quite	quite	RB
cord-270892-ycc3csyh	462	21	similar	similar	JJ
cord-270892-ycc3csyh	462	22	to	to	IN
cord-270892-ycc3csyh	462	23	the	the	DT
cord-270892-ycc3csyh	462	24	chemical	chemical	JJ
cord-270892-ycc3csyh	462	25	space	space	NN
cord-270892-ycc3csyh	462	26	occupied	occupy	VBN
cord-270892-ycc3csyh	462	27	by	by	IN
cord-270892-ycc3csyh	462	28	drug	drug	NN
cord-270892-ycc3csyh	462	29	substances	substance	NNS
cord-270892-ycc3csyh	462	30	.	.	.
cord-270892-ycc3csyh	463	1	The	the	DT
cord-270892-ycc3csyh	463	2	authors	author	NNS
cord-270892-ycc3csyh	463	3	accordingly	accordingly	RB
cord-270892-ycc3csyh	463	4	suggest	suggest	VBP
cord-270892-ycc3csyh	463	5	that	that	IN
cord-270892-ycc3csyh	463	6	combinatorial	combinatorial	JJ
cord-270892-ycc3csyh	463	7	libraries	library	NNS
cord-270892-ycc3csyh	463	8	that	that	WDT
cord-270892-ycc3csyh	463	9	mimic	mimic	VBP
cord-270892-ycc3csyh	463	10	the	the	DT
cord-270892-ycc3csyh	463	11	distribution	distribution	NN
cord-270892-ycc3csyh	463	12	properties	property	NNS
cord-270892-ycc3csyh	463	13	of	of	IN
cord-270892-ycc3csyh	463	14	natural	natural	JJ
cord-270892-ycc3csyh	463	15	products	product	NNS
cord-270892-ycc3csyh	463	16	might	may	MD
cord-270892-ycc3csyh	463	17	be	be	VB
cord-270892-ycc3csyh	463	18	more	more	RBR
cord-270892-ycc3csyh	463	19	biologically	biologically	RB
cord-270892-ycc3csyh	463	20	relevant	relevant	JJ
cord-270892-ycc3csyh	463	21	.	.	.
cord-270892-ycc3csyh	464	1	One	one	CD
cord-270892-ycc3csyh	464	2	may	may	MD
cord-270892-ycc3csyh	464	3	assume	assume	VB
cord-270892-ycc3csyh	464	4	that	that	IN
cord-270892-ycc3csyh	464	5	secondary	secondary	JJ
cord-270892-ycc3csyh	464	6	metabolites	metabolite	NNS
cord-270892-ycc3csyh	464	7	evolved	evolve	VBD
cord-270892-ycc3csyh	464	8	as	as	IN
cord-270892-ycc3csyh	464	9	reaction	reaction	NN
cord-270892-ycc3csyh	464	10	to	to	IN
cord-270892-ycc3csyh	464	11	their	-PRON-	PRP$
cord-270892-ycc3csyh	464	12	target	target	NN
cord-270892-ycc3csyh	464	13	receptors	receptor	NNS
cord-270892-ycc3csyh	464	14	related	relate	VBN
cord-270892-ycc3csyh	464	15	to	to	IN
cord-270892-ycc3csyh	464	16	defence	defence	NN
cord-270892-ycc3csyh	464	17	,	,	,
cord-270892-ycc3csyh	464	18	protection	protection	NN
cord-270892-ycc3csyh	464	19	,	,	,
cord-270892-ycc3csyh	464	20	attraction	attraction	NN
cord-270892-ycc3csyh	464	21	,	,	,
cord-270892-ycc3csyh	464	22	and	and	CC
cord-270892-ycc3csyh	464	23	signalling	signal	VBG
cord-270892-ycc3csyh	464	24	.	.	.
cord-270892-ycc3csyh	465	1	These	these	DT
cord-270892-ycc3csyh	465	2	adaptation	adaptation	NN
cord-270892-ycc3csyh	465	3	processes	process	NNS
cord-270892-ycc3csyh	465	4	have	have	VBP
cord-270892-ycc3csyh	465	5	enriched	enrich	VBN
cord-270892-ycc3csyh	465	6	not	not	RB
cord-270892-ycc3csyh	465	7	only	only	RB
cord-270892-ycc3csyh	465	8	the	the	DT
cord-270892-ycc3csyh	465	9	metabolites	metabolite	NNS
cord-270892-ycc3csyh	465	10	'	'	POS
cord-270892-ycc3csyh	465	11	structural	structural	JJ
cord-270892-ycc3csyh	465	12	diversity	diversity	NN
cord-270892-ycc3csyh	465	13	but	but	CC
cord-270892-ycc3csyh	465	14	have	have	VBP
cord-270892-ycc3csyh	465	15	also	also	RB
cord-270892-ycc3csyh	465	16	optimized	optimize	VBN
cord-270892-ycc3csyh	465	17	drug	drug	NN
cord-270892-ycc3csyh	465	18	-	-	HYPH
cord-270892-ycc3csyh	465	19	like	like	JJ
cord-270892-ycc3csyh	465	20	metabolic	metabolic	JJ
cord-270892-ycc3csyh	465	21	traits	trait	NNS
cord-270892-ycc3csyh	465	22	likely	likely	JJ
cord-270892-ycc3csyh	465	23	to	to	TO
cord-270892-ycc3csyh	465	24	have	have	VB
cord-270892-ycc3csyh	465	25	favorable	favorable	JJ
cord-270892-ycc3csyh	465	26	pharmacokinetic	pharmacokinetic	JJ
cord-270892-ycc3csyh	465	27	properties	property	NNS
cord-270892-ycc3csyh	465	28	.	.	.
cord-270892-ycc3csyh	466	1	271	271	CD
cord-270892-ycc3csyh	466	2	,	,	,
cord-270892-ycc3csyh	466	3	272	272	CD
cord-270892-ycc3csyh	467	1	It	-PRON-	PRP
cord-270892-ycc3csyh	467	2	is	be	VBZ
cord-270892-ycc3csyh	467	3	this	this	DT
cord-270892-ycc3csyh	467	4	evolutionary	evolutionary	JJ
cord-270892-ycc3csyh	467	5	concept	concept	NN
cord-270892-ycc3csyh	467	6	that	that	WDT
cord-270892-ycc3csyh	467	7	gives	give	VBZ
cord-270892-ycc3csyh	467	8	the	the	DT
cord-270892-ycc3csyh	467	9	pool	pool	NN
cord-270892-ycc3csyh	467	10	of	of	IN
cord-270892-ycc3csyh	467	11	natural	natural	JJ
cord-270892-ycc3csyh	467	12	products	product	NNS
cord-270892-ycc3csyh	467	13	the	the	DT
cord-270892-ycc3csyh	467	14	greatest	great	JJS
cord-270892-ycc3csyh	467	15	source	source	NN
cord-270892-ycc3csyh	467	16	of	of	IN
cord-270892-ycc3csyh	467	17	scaffold	scaffold	NN
cord-270892-ycc3csyh	467	18	diversity	diversity	NN
cord-270892-ycc3csyh	467	19	with	with	IN
cord-270892-ycc3csyh	467	20	molecules	molecule	NNS
cord-270892-ycc3csyh	467	21	of	of	IN
cord-270892-ycc3csyh	467	22	biological	biological	JJ
cord-270892-ycc3csyh	467	23	relevance	relevance	NN
cord-270892-ycc3csyh	467	24	.	.	.
cord-270892-ycc3csyh	468	1	Newman	Newman	NNP
cord-270892-ycc3csyh	468	2	and	and	CC
cord-270892-ycc3csyh	468	3	Cragg	Cragg	NNP
cord-270892-ycc3csyh	468	4	analyzed	analyze	VBD
cord-270892-ycc3csyh	468	5	the	the	DT
cord-270892-ycc3csyh	468	6	number	number	NN
cord-270892-ycc3csyh	468	7	of	of	IN
cord-270892-ycc3csyh	468	8	drugs	drug	NNS
cord-270892-ycc3csyh	468	9	approved	approve	VBN
cord-270892-ycc3csyh	468	10	between	between	IN
cord-270892-ycc3csyh	468	11	1981	1981	CD
cord-270892-ycc3csyh	468	12	and	and	CC
cord-270892-ycc3csyh	468	13	2006	2006	CD
cord-270892-ycc3csyh	468	14	and	and	CC
cord-270892-ycc3csyh	468	15	circumstantiated	circumstantiate	VBD
cord-270892-ycc3csyh	468	16	that	that	IN
cord-270892-ycc3csyh	468	17	especially	especially	RB
cord-270892-ycc3csyh	468	18	the	the	DT
cord-270892-ycc3csyh	468	19	anti	anti	JJ
cord-270892-ycc3csyh	468	20	-	-	JJ
cord-270892-ycc3csyh	468	21	infective	infective	JJ
cord-270892-ycc3csyh	468	22	area	area	NN
cord-270892-ycc3csyh	468	23	is	be	VBZ
cord-270892-ycc3csyh	468	24	strongly	strongly	RB
cord-270892-ycc3csyh	468	25	dependent	dependent	JJ
cord-270892-ycc3csyh	468	26	on	on	IN
cord-270892-ycc3csyh	468	27	natural	natural	JJ
cord-270892-ycc3csyh	468	28	products	product	NNS
cord-270892-ycc3csyh	468	29	and	and	CC
cord-270892-ycc3csyh	468	30	structures	structure	NNS
cord-270892-ycc3csyh	468	31	derived	derive	VBN
cord-270892-ycc3csyh	468	32	from	from	IN
cord-270892-ycc3csyh	468	33	natural	natural	JJ
cord-270892-ycc3csyh	468	34	scaffolds	scaffold	NNS
cord-270892-ycc3csyh	468	35	.	.	.
cord-270892-ycc3csyh	469	1	273	273	CD
cord-270892-ycc3csyh	470	1	The	the	DT
cord-270892-ycc3csyh	470	2	anti	anti	JJ
cord-270892-ycc3csyh	470	3	-	-	JJ
cord-270892-ycc3csyh	470	4	infectives	infective	NNS
cord-270892-ycc3csyh	470	5	including	include	VBG
cord-270892-ycc3csyh	470	6	the	the	DT
cord-270892-ycc3csyh	470	7	antiviral	antiviral	JJ
cord-270892-ycc3csyh	470	8	vaccines	vaccine	NNS
cord-270892-ycc3csyh	470	9	are	be	VBP
cord-270892-ycc3csyh	470	10	with	with	IN
cord-270892-ycc3csyh	470	11	22.8	22.8	CD
cord-270892-ycc3csyh	470	12	%	%	NN
cord-270892-ycc3csyh	470	13	or	or	CC
cord-270892-ycc3csyh	470	14	230	230	CD
cord-270892-ycc3csyh	470	15	launched	launch	VBN
cord-270892-ycc3csyh	470	16	drugs	drug	NNS
cord-270892-ycc3csyh	470	17	by	by	IN
cord-270892-ycc3csyh	470	18	far	far	RB
cord-270892-ycc3csyh	470	19	the	the	DT
cord-270892-ycc3csyh	470	20	major	major	JJ
cord-270892-ycc3csyh	470	21	category	category	NN
cord-270892-ycc3csyh	470	22	with	with	IN
cord-270892-ycc3csyh	470	23	only	only	RB
cord-270892-ycc3csyh	470	24	about	about	RB
cord-270892-ycc3csyh	470	25	30	30	CD
cord-270892-ycc3csyh	470	26	%	%	NN
cord-270892-ycc3csyh	470	27	being	be	VBG
cord-270892-ycc3csyh	470	28	synthetic	synthetic	JJ
cord-270892-ycc3csyh	470	29	in	in	IN
cord-270892-ycc3csyh	470	30	origin	origin	NN
cord-270892-ycc3csyh	470	31	.	.	.
cord-270892-ycc3csyh	471	1	From	from	IN
cord-270892-ycc3csyh	471	2	1981	1981	CD
cord-270892-ycc3csyh	471	3	to	to	IN
cord-270892-ycc3csyh	471	4	2006	2006	CD
cord-270892-ycc3csyh	471	5	,	,	,
cord-270892-ycc3csyh	471	6	78	78	CD
cord-270892-ycc3csyh	471	7	vaccines	vaccine	NNS
cord-270892-ycc3csyh	471	8	and	and	CC
cord-270892-ycc3csyh	471	9	antiviral	antiviral	JJ
cord-270892-ycc3csyh	471	10	drugs	drug	NNS
cord-270892-ycc3csyh	471	11	have	have	VBP
cord-270892-ycc3csyh	471	12	been	be	VBN
cord-270892-ycc3csyh	471	13	approved	approve	VBN
cord-270892-ycc3csyh	471	14	.	.	.
cord-270892-ycc3csyh	472	1	Excluding	exclude	VBG
cord-270892-ycc3csyh	472	2	the	the	DT
cord-270892-ycc3csyh	472	3	high	high	JJ
cord-270892-ycc3csyh	472	4	number	number	NN
cord-270892-ycc3csyh	472	5	of	of	IN
cord-270892-ycc3csyh	472	6	vaccines	vaccine	NNS
cord-270892-ycc3csyh	472	7	(	(	-LRB-
cord-270892-ycc3csyh	472	8	25	25	CD
cord-270892-ycc3csyh	472	9	)	)	-RRB-
cord-270892-ycc3csyh	472	10	and	and	CC
cord-270892-ycc3csyh	472	11	biologicals	biological	NNS
cord-270892-ycc3csyh	472	12	(	(	-LRB-
cord-270892-ycc3csyh	472	13	12	12	CD
cord-270892-ycc3csyh	472	14	)	)	-RRB-
cord-270892-ycc3csyh	472	15	,	,	,
cord-270892-ycc3csyh	472	16	most	most	JJS
cord-270892-ycc3csyh	472	17	of	of	IN
cord-270892-ycc3csyh	472	18	the	the	DT
cord-270892-ycc3csyh	472	19	41	41	CD
cord-270892-ycc3csyh	472	20	small	small	JJ
cord-270892-ycc3csyh	472	21	antiviral	antiviral	JJ
cord-270892-ycc3csyh	472	22	molecules	molecule	NNS
cord-270892-ycc3csyh	472	23	are	be	VBP
cord-270892-ycc3csyh	472	24	based	base	VBN
cord-270892-ycc3csyh	472	25	on	on	IN
cord-270892-ycc3csyh	472	26	nucleoside	nucleoside	JJ
cord-270892-ycc3csyh	472	27	structures	structure	NNS
cord-270892-ycc3csyh	472	28	or	or	CC
cord-270892-ycc3csyh	472	29	on	on	IN
cord-270892-ycc3csyh	472	30	peptidomimetics	peptidomimetic	NNS
cord-270892-ycc3csyh	472	31	;	;	:
cord-270892-ycc3csyh	472	32	only	only	RB
cord-270892-ycc3csyh	472	33	16.7	16.7	CD
cord-270892-ycc3csyh	472	34	%	%	NN
cord-270892-ycc3csyh	472	35	are	be	VBP
cord-270892-ycc3csyh	472	36	classified	classify	VBN
cord-270892-ycc3csyh	472	37	as	as	IN
cord-270892-ycc3csyh	472	38	totally	totally	RB
cord-270892-ycc3csyh	472	39	synthetic	synthetic	JJ
cord-270892-ycc3csyh	472	40	drugs	drug	NNS
cord-270892-ycc3csyh	472	41	.	.	.
cord-270892-ycc3csyh	473	1	However	however	RB
cord-270892-ycc3csyh	473	2	,	,	,
cord-270892-ycc3csyh	473	3	till	till	IN
cord-270892-ycc3csyh	473	4	now	now	RB
cord-270892-ycc3csyh	473	5	,	,	,
cord-270892-ycc3csyh	473	6	neither	neither	CC
cord-270892-ycc3csyh	473	7	a	a	DT
cord-270892-ycc3csyh	473	8	synthetic	synthetic	NN
cord-270892-ycc3csyh	473	9	nor	nor	CC
cord-270892-ycc3csyh	473	10	a	a	DT
cord-270892-ycc3csyh	473	11	naturally	naturally	RB
cord-270892-ycc3csyh	473	12	derived	derive	VBN
cord-270892-ycc3csyh	473	13	anti	anti	JJ
cord-270892-ycc3csyh	473	14	-	-	JJ
cord-270892-ycc3csyh	473	15	HRV	HRV	NNP
cord-270892-ycc3csyh	473	16	drug	drug	NN
cord-270892-ycc3csyh	473	17	substance	substance	NN
cord-270892-ycc3csyh	473	18	has	have	VBZ
cord-270892-ycc3csyh	473	19	been	be	VBN
cord-270892-ycc3csyh	473	20	approved	approve	VBN
cord-270892-ycc3csyh	473	21	for	for	IN
cord-270892-ycc3csyh	473	22	the	the	DT
cord-270892-ycc3csyh	473	23	treatment	treatment	NN
cord-270892-ycc3csyh	473	24	or	or	CC
cord-270892-ycc3csyh	473	25	prevention	prevention	NN
cord-270892-ycc3csyh	473	26	of	of	IN
cord-270892-ycc3csyh	473	27	HRV	HRV	NNP
cord-270892-ycc3csyh	473	28	infections	infection	NNS
cord-270892-ycc3csyh	473	29	.	.	.
cord-270892-ycc3csyh	474	1	Intensive	intensive	JJ
cord-270892-ycc3csyh	474	2	research	research	NN
cord-270892-ycc3csyh	474	3	and	and	CC
cord-270892-ycc3csyh	474	4	development	development	NN
cord-270892-ycc3csyh	474	5	efforts	effort	NNS
cord-270892-ycc3csyh	474	6	in	in	IN
cord-270892-ycc3csyh	474	7	the	the	DT
cord-270892-ycc3csyh	474	8	field	field	NN
cord-270892-ycc3csyh	474	9	of	of	IN
cord-270892-ycc3csyh	474	10	natural	natural	JJ
cord-270892-ycc3csyh	474	11	products	product	NNS
cord-270892-ycc3csyh	474	12	revealed	reveal	VBD
cord-270892-ycc3csyh	474	13	several	several	JJ
cord-270892-ycc3csyh	474	14	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	474	15	of	of	IN
cord-270892-ycc3csyh	474	16	viral	viral	JJ
cord-270892-ycc3csyh	474	17	attachment	attachment	NN
cord-270892-ycc3csyh	474	18	and	and	CC
cord-270892-ycc3csyh	474	19	entry	entry	NN
cord-270892-ycc3csyh	474	20	,	,	,
cord-270892-ycc3csyh	474	21	and	and	CC
cord-270892-ycc3csyh	474	22	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	474	23	of	of	IN
cord-270892-ycc3csyh	474	24	viral	viral	JJ
cord-270892-ycc3csyh	474	25	protease	protease	NN
cord-270892-ycc3csyh	474	26	from	from	IN
cord-270892-ycc3csyh	474	27	natural	natural	JJ
cord-270892-ycc3csyh	474	28	sources	source	NNS
cord-270892-ycc3csyh	474	29	.	.	.
cord-270892-ycc3csyh	475	1	The	the	DT
cord-270892-ycc3csyh	475	2	efficacy	efficacy	NN
cord-270892-ycc3csyh	475	3	of	of	IN
cord-270892-ycc3csyh	475	4	natural	natural	JJ
cord-270892-ycc3csyh	475	5	products	product	NNS
cord-270892-ycc3csyh	475	6	is	be	VBZ
cord-270892-ycc3csyh	475	7	not	not	RB
cord-270892-ycc3csyh	475	8	only	only	RB
cord-270892-ycc3csyh	475	9	reflected	reflect	VBN
cord-270892-ycc3csyh	475	10	by	by	IN
cord-270892-ycc3csyh	475	11	statistics	statistic	NNS
cord-270892-ycc3csyh	475	12	of	of	IN
cord-270892-ycc3csyh	475	13	launched	launch	VBN
cord-270892-ycc3csyh	475	14	drugs	drug	NNS
cord-270892-ycc3csyh	475	15	but	but	CC
cord-270892-ycc3csyh	475	16	also	also	RB
cord-270892-ycc3csyh	475	17	by	by	IN
cord-270892-ycc3csyh	475	18	empirical	empirical	JJ
cord-270892-ycc3csyh	475	19	knowledge	knowledge	NN
cord-270892-ycc3csyh	475	20	gained	gain	VBN
cord-270892-ycc3csyh	475	21	over	over	IN
cord-270892-ycc3csyh	475	22	centuries	century	NNS
cord-270892-ycc3csyh	475	23	by	by	IN
cord-270892-ycc3csyh	475	24	successful	successful	JJ
cord-270892-ycc3csyh	475	25	application	application	NN
cord-270892-ycc3csyh	475	26	of	of	IN
cord-270892-ycc3csyh	475	27	naturalbased	naturalbased	JJ
cord-270892-ycc3csyh	475	28	ethnomedicinal	ethnomedicinal	JJ
cord-270892-ycc3csyh	475	29	products	product	NNS
cord-270892-ycc3csyh	475	30	such	such	JJ
cord-270892-ycc3csyh	475	31	as	as	IN
cord-270892-ycc3csyh	475	32	plants	plant	NNS
cord-270892-ycc3csyh	475	33	,	,	,
cord-270892-ycc3csyh	475	34	culinary	culinary	JJ
cord-270892-ycc3csyh	475	35	herbs	herb	NNS
cord-270892-ycc3csyh	475	36	,	,	,
cord-270892-ycc3csyh	475	37	and	and	CC
cord-270892-ycc3csyh	475	38	spices	spice	NNS
cord-270892-ycc3csyh	475	39	.	.	.
cord-270892-ycc3csyh	476	1	Phytochemical	phytochemical	JJ
cord-270892-ycc3csyh	476	2	and	and	CC
cord-270892-ycc3csyh	476	3	pharmacological	pharmacological	JJ
cord-270892-ycc3csyh	476	4	work	work	NN
cord-270892-ycc3csyh	476	5	performed	perform	VBN
cord-270892-ycc3csyh	476	6	with	with	IN
cord-270892-ycc3csyh	476	7	ethnomedicinal	ethnomedicinal	JJ
cord-270892-ycc3csyh	476	8	anti	anti	JJ
cord-270892-ycc3csyh	476	9	-	-	NNP
cord-270892-ycc3csyh	476	10	HRVs	hrvs	JJ
cord-270892-ycc3csyh	476	11	mainly	mainly	RB
cord-270892-ycc3csyh	476	12	from	from	IN
cord-270892-ycc3csyh	476	13	plants	plant	NNS
cord-270892-ycc3csyh	476	14	revealed	reveal	VBD
cord-270892-ycc3csyh	476	15	a	a	DT
cord-270892-ycc3csyh	476	16	high	high	JJ
cord-270892-ycc3csyh	476	17	number	number	NN
cord-270892-ycc3csyh	476	18	of	of	IN
cord-270892-ycc3csyh	476	19	active	active	JJ
cord-270892-ycc3csyh	476	20	metabolites	metabolite	NNS
cord-270892-ycc3csyh	476	21	from	from	IN
cord-270892-ycc3csyh	476	22	different	different	JJ
cord-270892-ycc3csyh	476	23	chemical	chemical	NN
cord-270892-ycc3csyh	476	24	classes	class	NNS
cord-270892-ycc3csyh	476	25	,	,	,
cord-270892-ycc3csyh	476	26	e.g.	e.g.	IN
cord-270892-ycc3csyh	476	27	coumarins	coumarin	NNS
cord-270892-ycc3csyh	476	28	,	,	,
cord-270892-ycc3csyh	476	29	flavonoids	flavonoid	NNS
cord-270892-ycc3csyh	476	30	,	,	,
cord-270892-ycc3csyh	476	31	alkaloids	alkaloid	NNS
cord-270892-ycc3csyh	476	32	,	,	,
cord-270892-ycc3csyh	476	33	quinones	quinone	NNS
cord-270892-ycc3csyh	476	34	,	,	,
cord-270892-ycc3csyh	476	35	terpenoids	terpenoid	NNS
cord-270892-ycc3csyh	476	36	,	,	,
cord-270892-ycc3csyh	476	37	polyphenols	polyphenol	NNS
cord-270892-ycc3csyh	476	38	,	,	,
cord-270892-ycc3csyh	476	39	and	and	CC
cord-270892-ycc3csyh	476	40	polysaccharides	polysaccharide	NNS
cord-270892-ycc3csyh	476	41	.	.	.
cord-270892-ycc3csyh	477	1	Natural	natural	JJ
cord-270892-ycc3csyh	477	2	products	product	NNS
cord-270892-ycc3csyh	477	3	include	include	VBP
cord-270892-ycc3csyh	477	4	complex	complex	JJ
cord-270892-ycc3csyh	477	5	extracts	extract	NNS
cord-270892-ycc3csyh	477	6	and	and	CC
cord-270892-ycc3csyh	477	7	their	-PRON-	PRP$
cord-270892-ycc3csyh	477	8	chemical	chemical	JJ
cord-270892-ycc3csyh	477	9	entities	entity	NNS
cord-270892-ycc3csyh	477	10	,	,	,
cord-270892-ycc3csyh	477	11	which	which	WDT
cord-270892-ycc3csyh	477	12	are	be	VBP
cord-270892-ycc3csyh	477	13	biosynthesized	biosynthesize	VBN
cord-270892-ycc3csyh	477	14	by	by	IN
cord-270892-ycc3csyh	477	15	nature	nature	NN
cord-270892-ycc3csyh	477	16	.	.	.
cord-270892-ycc3csyh	478	1	For	for	IN
cord-270892-ycc3csyh	478	2	an	an	DT
cord-270892-ycc3csyh	478	3	unambiguous	unambiguous	JJ
cord-270892-ycc3csyh	478	4	presentation	presentation	NN
cord-270892-ycc3csyh	478	5	of	of	IN
cord-270892-ycc3csyh	478	6	anti	anti	JJ
cord-270892-ycc3csyh	478	7	-	-	JJ
cord-270892-ycc3csyh	478	8	HRV	HRV	NNP
cord-270892-ycc3csyh	478	9	natural	natural	JJ
cord-270892-ycc3csyh	478	10	products	product	NNS
cord-270892-ycc3csyh	478	11	it	-PRON-	PRP
cord-270892-ycc3csyh	478	12	is	be	VBZ
cord-270892-ycc3csyh	478	13	of	of	IN
cord-270892-ycc3csyh	478	14	prior	prior	JJ
cord-270892-ycc3csyh	478	15	importance	importance	NN
cord-270892-ycc3csyh	478	16	to	to	IN
cord-270892-ycc3csyh	478	17	first	first	RB
cord-270892-ycc3csyh	478	18	distinguish	distinguish	VB
cord-270892-ycc3csyh	478	19	between	between	IN
cord-270892-ycc3csyh	478	20	a	a	DT
cord-270892-ycc3csyh	478	21	single	single	JJ
cord-270892-ycc3csyh	478	22	chemical	chemical	NN
cord-270892-ycc3csyh	478	23	entity	entity	NN
cord-270892-ycc3csyh	478	24	from	from	IN
cord-270892-ycc3csyh	478	25	nature	nature	NN
cord-270892-ycc3csyh	478	26	,	,	,
cord-270892-ycc3csyh	478	27	i.e.	i.e.	FW
cord-270892-ycc3csyh	478	28	an	an	DT
cord-270892-ycc3csyh	478	29	isolated	isolate	VBN
cord-270892-ycc3csyh	478	30	,	,	,
cord-270892-ycc3csyh	478	31	purified	purify	VBN
cord-270892-ycc3csyh	478	32	natural	natural	JJ
cord-270892-ycc3csyh	478	33	compound	compound	NN
cord-270892-ycc3csyh	478	34	,	,	,
cord-270892-ycc3csyh	478	35	on	on	IN
cord-270892-ycc3csyh	478	36	one	one	CD
cord-270892-ycc3csyh	478	37	hand	hand	NN
cord-270892-ycc3csyh	478	38	,	,	,
cord-270892-ycc3csyh	478	39	and	and	CC
cord-270892-ycc3csyh	478	40	a	a	DT
cord-270892-ycc3csyh	478	41	natural	natural	JJ
cord-270892-ycc3csyh	478	42	preparation	preparation	NN
cord-270892-ycc3csyh	478	43	comprising	comprise	VBG
cord-270892-ycc3csyh	478	44	hundreds	hundred	NNS
cord-270892-ycc3csyh	478	45	to	to	IN
cord-270892-ycc3csyh	478	46	thousands	thousand	NNS
cord-270892-ycc3csyh	478	47	of	of	IN
cord-270892-ycc3csyh	478	48	constituents	constituent	NNS
cord-270892-ycc3csyh	478	49	,	,	,
cord-270892-ycc3csyh	478	50	mainly	mainly	RB
cord-270892-ycc3csyh	478	51	secondary	secondary	JJ
cord-270892-ycc3csyh	478	52	metabolites	metabolite	NNS
cord-270892-ycc3csyh	478	53	,	,	,
cord-270892-ycc3csyh	478	54	on	on	IN
cord-270892-ycc3csyh	478	55	the	the	DT
cord-270892-ycc3csyh	478	56	other	other	JJ
cord-270892-ycc3csyh	478	57	hand	hand	NN
cord-270892-ycc3csyh	478	58	.	.	.
cord-270892-ycc3csyh	479	1	If	if	IN
cord-270892-ycc3csyh	479	2	natural	natural	JJ
cord-270892-ycc3csyh	479	3	preparations	preparation	NNS
cord-270892-ycc3csyh	479	4	are	be	VBP
cord-270892-ycc3csyh	479	5	derived	derive	VBN
cord-270892-ycc3csyh	479	6	from	from	IN
cord-270892-ycc3csyh	479	7	plants	plant	NNS
cord-270892-ycc3csyh	479	8	,	,	,
cord-270892-ycc3csyh	479	9	they	-PRON-	PRP
cord-270892-ycc3csyh	479	10	might	may	MD
cord-270892-ycc3csyh	479	11	also	also	RB
cord-270892-ycc3csyh	479	12	be	be	VB
cord-270892-ycc3csyh	479	13	labelled	label	VBN
cord-270892-ycc3csyh	479	14	as	as	IN
cord-270892-ycc3csyh	479	15	botanicals	botanical	NNS
cord-270892-ycc3csyh	479	16	,	,	,
cord-270892-ycc3csyh	479	17	phytoceuticals	phytoceutical	NNS
cord-270892-ycc3csyh	479	18	,	,	,
cord-270892-ycc3csyh	479	19	or	or	CC
cord-270892-ycc3csyh	479	20	phytotherapeutic	phytotherapeutic	JJ
cord-270892-ycc3csyh	479	21	agents	agent	NNS
cord-270892-ycc3csyh	479	22	.	.	.
cord-270892-ycc3csyh	480	1	These	these	DT
cord-270892-ycc3csyh	480	2	multicomponent	multicomponent	JJ
cord-270892-ycc3csyh	480	3	preparations	preparation	NNS
cord-270892-ycc3csyh	480	4	might	may	MD
cord-270892-ycc3csyh	480	5	show	show	VB
cord-270892-ycc3csyh	480	6	a	a	DT
cord-270892-ycc3csyh	480	7	varying	vary	VBG
cord-270892-ycc3csyh	480	8	profile	profile	NN
cord-270892-ycc3csyh	480	9	of	of	IN
cord-270892-ycc3csyh	480	10	their	-PRON-	PRP$
cord-270892-ycc3csyh	480	11	constituents	constituent	NNS
cord-270892-ycc3csyh	480	12	depending	depend	VBG
cord-270892-ycc3csyh	480	13	on	on	IN
cord-270892-ycc3csyh	480	14	the	the	DT
cord-270892-ycc3csyh	480	15	used	use	VBN
cord-270892-ycc3csyh	480	16	species	species	NN
cord-270892-ycc3csyh	480	17	,	,	,
cord-270892-ycc3csyh	480	18	origin	origin	NN
cord-270892-ycc3csyh	480	19	,	,	,
cord-270892-ycc3csyh	480	20	collection	collection	NN
cord-270892-ycc3csyh	480	21	time	time	NN
cord-270892-ycc3csyh	480	22	,	,	,
cord-270892-ycc3csyh	480	23	plant	plant	NN
cord-270892-ycc3csyh	480	24	parts	part	NNS
cord-270892-ycc3csyh	480	25	,	,	,
cord-270892-ycc3csyh	480	26	extraction	extraction	NN
cord-270892-ycc3csyh	480	27	procedures	procedure	NNS
cord-270892-ycc3csyh	480	28	,	,	,
cord-270892-ycc3csyh	480	29	preparation	preparation	NN
cord-270892-ycc3csyh	480	30	methods	method	NNS
cord-270892-ycc3csyh	480	31	,	,	,
cord-270892-ycc3csyh	480	32	and	and	CC
cord-270892-ycc3csyh	480	33	manufacturing	manufacturing	NN
cord-270892-ycc3csyh	480	34	processes	process	NNS
cord-270892-ycc3csyh	480	35	,	,	,
cord-270892-ycc3csyh	480	36	just	just	RB
cord-270892-ycc3csyh	480	37	to	to	TO
cord-270892-ycc3csyh	480	38	mention	mention	VB
cord-270892-ycc3csyh	480	39	a	a	DT
cord-270892-ycc3csyh	480	40	few	few	JJ
cord-270892-ycc3csyh	480	41	important	important	JJ
cord-270892-ycc3csyh	480	42	elements	element	NNS
cord-270892-ycc3csyh	480	43	.	.	.
cord-270892-ycc3csyh	481	1	These	these	DT
cord-270892-ycc3csyh	481	2	parameters	parameter	NNS
cord-270892-ycc3csyh	481	3	affect	affect	VBP
cord-270892-ycc3csyh	481	4	the	the	DT
cord-270892-ycc3csyh	481	5	final	final	JJ
cord-270892-ycc3csyh	481	6	product	product	NN
cord-270892-ycc3csyh	481	7	in	in	IN
cord-270892-ycc3csyh	481	8	terms	term	NNS
cord-270892-ycc3csyh	481	9	of	of	IN
cord-270892-ycc3csyh	481	10	the	the	DT
cord-270892-ycc3csyh	481	11	qualitative	qualitative	JJ
cord-270892-ycc3csyh	481	12	and	and	CC
cord-270892-ycc3csyh	481	13	quantitative	quantitative	JJ
cord-270892-ycc3csyh	481	14	composition	composition	NN
cord-270892-ycc3csyh	481	15	of	of	IN
cord-270892-ycc3csyh	481	16	chemical	chemical	JJ
cord-270892-ycc3csyh	481	17	constituents	constituent	NNS
cord-270892-ycc3csyh	481	18	,	,	,
cord-270892-ycc3csyh	481	19	which	which	WDT
cord-270892-ycc3csyh	481	20	may	may	MD
cord-270892-ycc3csyh	481	21	have	have	VB
cord-270892-ycc3csyh	481	22	an	an	DT
cord-270892-ycc3csyh	481	23	impact	impact	NN
cord-270892-ycc3csyh	481	24	in	in	IN
cord-270892-ycc3csyh	481	25	biological	biological	JJ
cord-270892-ycc3csyh	481	26	activity	activity	NN
cord-270892-ycc3csyh	481	27	.	.	.
cord-270892-ycc3csyh	482	1	Accordingly	accordingly	RB
cord-270892-ycc3csyh	482	2	,	,	,
cord-270892-ycc3csyh	482	3	studies	study	NNS
cord-270892-ycc3csyh	482	4	performed	perform	VBN
cord-270892-ycc3csyh	482	5	with	with	IN
cord-270892-ycc3csyh	482	6	phytochemically	phytochemically	RB
cord-270892-ycc3csyh	482	7	not	not	RB
cord-270892-ycc3csyh	482	8	specified	specify	VBN
cord-270892-ycc3csyh	482	9	extracts	extract	NNS
cord-270892-ycc3csyh	482	10	or	or	CC
cord-270892-ycc3csyh	482	11	nonstandardized	nonstandardize	VBN
cord-270892-ycc3csyh	482	12	preparations	preparation	NNS
cord-270892-ycc3csyh	482	13	often	often	RB
cord-270892-ycc3csyh	482	14	suffer	suffer	VBP
cord-270892-ycc3csyh	482	15	from	from	IN
cord-270892-ycc3csyh	482	16	irreproducible	irreproducible	JJ
cord-270892-ycc3csyh	482	17	and	and	CC
cord-270892-ycc3csyh	482	18	incomparable	incomparable	JJ
cord-270892-ycc3csyh	482	19	results	result	NNS
cord-270892-ycc3csyh	483	1	A	a	DT
cord-270892-ycc3csyh	483	2	wide	wide	JJ
cord-270892-ycc3csyh	483	3	variety	variety	NN
cord-270892-ycc3csyh	483	4	of	of	IN
cord-270892-ycc3csyh	483	5	natural	natural	JJ
cord-270892-ycc3csyh	483	6	preparations	preparation	NNS
cord-270892-ycc3csyh	483	7	showed	show	VBD
cord-270892-ycc3csyh	483	8	to	to	TO
cord-270892-ycc3csyh	483	9	be	be	VB
cord-270892-ycc3csyh	483	10	acting	act	VBG
cord-270892-ycc3csyh	483	11	therapeutically	therapeutically	RB
cord-270892-ycc3csyh	483	12	in	in	IN
cord-270892-ycc3csyh	483	13	HRV	HRV	NNP
cord-270892-ycc3csyh	483	14	and	and	CC
cord-270892-ycc3csyh	483	15	other	other	JJ
cord-270892-ycc3csyh	483	16	viral	viral	JJ
cord-270892-ycc3csyh	483	17	infections	infection	NNS
cord-270892-ycc3csyh	483	18	with	with	IN
cord-270892-ycc3csyh	483	19	often	often	RB
cord-270892-ycc3csyh	483	20	complementary	complementary	JJ
cord-270892-ycc3csyh	483	21	and	and	CC
cord-270892-ycc3csyh	483	22	overlapping	overlapping	JJ
cord-270892-ycc3csyh	483	23	antiviral	antiviral	JJ
cord-270892-ycc3csyh	483	24	mechanisms	mechanism	NNS
cord-270892-ycc3csyh	483	25	of	of	IN
cord-270892-ycc3csyh	483	26	action	action	NN
cord-270892-ycc3csyh	483	27	.	.	.
cord-270892-ycc3csyh	484	1	[	[	-LRB-
cord-270892-ycc3csyh	484	2	274	274	CD
cord-270892-ycc3csyh	484	3	]	]	-RRB-
cord-270892-ycc3csyh	484	4	[	[	-LRB-
cord-270892-ycc3csyh	484	5	275	275	CD
cord-270892-ycc3csyh	484	6	]	]	-RRB-
cord-270892-ycc3csyh	485	1	[	[	-LRB-
cord-270892-ycc3csyh	485	2	276	276	CD
cord-270892-ycc3csyh	485	3	]	]	-RRB-
cord-270892-ycc3csyh	486	1	Most	Most	JJS
cord-270892-ycc3csyh	486	2	of	of	IN
cord-270892-ycc3csyh	486	3	these	these	DT
cord-270892-ycc3csyh	486	4	remedies	remedy	NNS
cord-270892-ycc3csyh	486	5	are	be	VBP
cord-270892-ycc3csyh	486	6	described	describe	VBN
cord-270892-ycc3csyh	486	7	in	in	IN
cord-270892-ycc3csyh	486	8	ethnopharmacological	ethnopharmacological	JJ
cord-270892-ycc3csyh	486	9	sources	source	NNS
cord-270892-ycc3csyh	486	10	or	or	CC
cord-270892-ycc3csyh	486	11	handed	hand	VBD
cord-270892-ycc3csyh	486	12	down	down	RP
cord-270892-ycc3csyh	486	13	for	for	IN
cord-270892-ycc3csyh	486	14	generations	generation	NNS
cord-270892-ycc3csyh	486	15	.	.	.
cord-270892-ycc3csyh	487	1	They	-PRON-	PRP
cord-270892-ycc3csyh	487	2	usually	usually	RB
cord-270892-ycc3csyh	487	3	consist	consist	VBP
cord-270892-ycc3csyh	487	4	of	of	IN
cord-270892-ycc3csyh	487	5	simply	simply	RB
cord-270892-ycc3csyh	487	6	prepared	prepare	VBN
cord-270892-ycc3csyh	487	7	natural	natural	JJ
cord-270892-ycc3csyh	487	8	items	item	NNS
cord-270892-ycc3csyh	487	9	whose	whose	WP$
cord-270892-ycc3csyh	487	10	chemical	chemical	NN
cord-270892-ycc3csyh	487	11	composition	composition	NN
cord-270892-ycc3csyh	487	12	is	be	VBZ
cord-270892-ycc3csyh	487	13	complex	complex	JJ
cord-270892-ycc3csyh	487	14	.	.	.
cord-270892-ycc3csyh	488	1	Many	many	JJ
cord-270892-ycc3csyh	488	2	of	of	IN
cord-270892-ycc3csyh	488	3	the	the	DT
cord-270892-ycc3csyh	488	4	contained	contain	VBN
cord-270892-ycc3csyh	488	5	secondary	secondary	JJ
cord-270892-ycc3csyh	488	6	metabolites	metabolite	NNS
cord-270892-ycc3csyh	488	7	,	,	,
cord-270892-ycc3csyh	488	8	possibly	possibly	RB
cord-270892-ycc3csyh	488	9	active	active	JJ
cord-270892-ycc3csyh	488	10	principles	principle	NNS
cord-270892-ycc3csyh	488	11	,	,	,
cord-270892-ycc3csyh	488	12	have	have	VBP
cord-270892-ycc3csyh	488	13	never	never	RB
cord-270892-ycc3csyh	488	14	been	be	VBN
cord-270892-ycc3csyh	488	15	examined	examine	VBN
cord-270892-ycc3csyh	488	16	chemically	chemically	RB
cord-270892-ycc3csyh	488	17	or	or	CC
cord-270892-ycc3csyh	488	18	biochemically	biochemically	RB
cord-270892-ycc3csyh	488	19	using	use	VBG
cord-270892-ycc3csyh	488	20	modern	modern	JJ
cord-270892-ycc3csyh	488	21	medical	medical	JJ
cord-270892-ycc3csyh	488	22	knowledge	knowledge	NN
cord-270892-ycc3csyh	488	23	.	.	.
cord-270892-ycc3csyh	489	1	They	-PRON-	PRP
cord-270892-ycc3csyh	489	2	are	be	VBP
cord-270892-ycc3csyh	489	3	however	however	RB
cord-270892-ycc3csyh	489	4	components	component	NNS
cord-270892-ycc3csyh	489	5	of	of	IN
cord-270892-ycc3csyh	489	6	plant	plant	NN
cord-270892-ycc3csyh	489	7	medicines	medicine	NNS
cord-270892-ycc3csyh	489	8	,	,	,
cord-270892-ycc3csyh	489	9	which	which	WDT
cord-270892-ycc3csyh	489	10	have	have	VBP
cord-270892-ycc3csyh	489	11	stood	stand	VBN
cord-270892-ycc3csyh	489	12	the	the	DT
cord-270892-ycc3csyh	489	13	test	test	NN
cord-270892-ycc3csyh	489	14	of	of	IN
cord-270892-ycc3csyh	489	15	time	time	NN
cord-270892-ycc3csyh	489	16	and	and	CC
cord-270892-ycc3csyh	489	17	as	as	IN
cord-270892-ycc3csyh	489	18	such	such	JJ
cord-270892-ycc3csyh	489	19	may	may	MD
cord-270892-ycc3csyh	489	20	offer	offer	VB
cord-270892-ycc3csyh	489	21	clues	clue	NNS
cord-270892-ycc3csyh	489	22	of	of	IN
cord-270892-ycc3csyh	489	23	great	great	JJ
cord-270892-ycc3csyh	489	24	interest	interest	NN
cord-270892-ycc3csyh	489	25	to	to	IN
cord-270892-ycc3csyh	489	26	medicinal	medicinal	JJ
cord-270892-ycc3csyh	489	27	chemists	chemist	NNS
cord-270892-ycc3csyh	489	28	.	.	.
cord-270892-ycc3csyh	490	1	A	a	DT
cord-270892-ycc3csyh	490	2	clear	clear	JJ
cord-270892-ycc3csyh	490	3	advantage	advantage	NN
cord-270892-ycc3csyh	490	4	of	of	IN
cord-270892-ycc3csyh	490	5	the	the	DT
cord-270892-ycc3csyh	490	6	application	application	NN
cord-270892-ycc3csyh	490	7	of	of	IN
cord-270892-ycc3csyh	490	8	these	these	DT
cord-270892-ycc3csyh	490	9	products	product	NNS
cord-270892-ycc3csyh	490	10	is	be	VBZ
cord-270892-ycc3csyh	490	11	their	-PRON-	PRP$
cord-270892-ycc3csyh	490	12	absent	absent	JJ
cord-270892-ycc3csyh	490	13	or	or	CC
cord-270892-ycc3csyh	490	14	relatively	relatively	RB
cord-270892-ycc3csyh	490	15	low	low	JJ
cord-270892-ycc3csyh	490	16	toxicity	toxicity	NN
cord-270892-ycc3csyh	490	17	due	due	IN
cord-270892-ycc3csyh	490	18	to	to	IN
cord-270892-ycc3csyh	490	19	a	a	DT
cord-270892-ycc3csyh	490	20	usually	usually	RB
cord-270892-ycc3csyh	490	21	long	long	JJ
cord-270892-ycc3csyh	490	22	-	-	HYPH
cord-270892-ycc3csyh	490	23	term	term	NN
cord-270892-ycc3csyh	490	24	empirical	empirical	JJ
cord-270892-ycc3csyh	490	25	trial	trial	NN
cord-270892-ycc3csyh	490	26	.	.	.
cord-270892-ycc3csyh	491	1	Although	although	IN
cord-270892-ycc3csyh	491	2	the	the	DT
cord-270892-ycc3csyh	491	3	knowledge	knowledge	NN
cord-270892-ycc3csyh	491	4	of	of	IN
cord-270892-ycc3csyh	491	5	the	the	DT
cord-270892-ycc3csyh	491	6	immuno	immuno	JJ
cord-270892-ycc3csyh	491	7	-	-	JJ
cord-270892-ycc3csyh	491	8	pathogenesis	pathogenesis	NN
cord-270892-ycc3csyh	491	9	of	of	IN
cord-270892-ycc3csyh	491	10	RV	rv	NN
cord-270892-ycc3csyh	491	11	-	-	HYPH
cord-270892-ycc3csyh	491	12	induced	induce	VBN
cord-270892-ycc3csyh	491	13	diseases	disease	NNS
cord-270892-ycc3csyh	491	14	remains	remain	VBZ
cord-270892-ycc3csyh	491	15	limited	limit	VBN
cord-270892-ycc3csyh	491	16	,	,	,
cord-270892-ycc3csyh	491	17	the	the	DT
cord-270892-ycc3csyh	491	18	host	host	NN
cord-270892-ycc3csyh	491	19	defense	defense	NN
cord-270892-ycc3csyh	491	20	function	function	NN
cord-270892-ycc3csyh	491	21	of	of	IN
cord-270892-ycc3csyh	491	22	the	the	DT
cord-270892-ycc3csyh	491	23	airway	airway	NN
cord-270892-ycc3csyh	491	24	epithelium	epithelium	NN
cord-270892-ycc3csyh	491	25	plays	play	VBZ
cord-270892-ycc3csyh	491	26	an	an	DT
cord-270892-ycc3csyh	491	27	important	important	JJ
cord-270892-ycc3csyh	491	28	role	role	NN
cord-270892-ycc3csyh	491	29	in	in	IN
cord-270892-ycc3csyh	491	30	the	the	DT
cord-270892-ycc3csyh	491	31	innate	innate	JJ
cord-270892-ycc3csyh	491	32	-	-	HYPH
cord-270892-ycc3csyh	491	33	immune	immune	JJ
cord-270892-ycc3csyh	491	34	response	response	NN
cord-270892-ycc3csyh	491	35	to	to	IN
cord-270892-ycc3csyh	491	36	HRV	HRV	NNP
cord-270892-ycc3csyh	491	37	-	-	HYPH
cord-270892-ycc3csyh	491	38	infection	infection	NN
cord-270892-ycc3csyh	491	39	.	.	.
cord-270892-ycc3csyh	492	1	277	277	CD
cord-270892-ycc3csyh	492	2	Host	host	NN
cord-270892-ycc3csyh	492	3	cells	cell	NNS
cord-270892-ycc3csyh	492	4	respond	respond	VBP
cord-270892-ycc3csyh	492	5	by	by	IN
cord-270892-ycc3csyh	492	6	the	the	DT
cord-270892-ycc3csyh	492	7	production	production	NN
cord-270892-ycc3csyh	492	8	of	of	IN
cord-270892-ycc3csyh	492	9	mediators	mediator	NNS
cord-270892-ycc3csyh	492	10	with	with	IN
cord-270892-ycc3csyh	492	11	antiviral	antiviral	JJ
cord-270892-ycc3csyh	492	12	activity	activity	NN
cord-270892-ycc3csyh	492	13	such	such	JJ
cord-270892-ycc3csyh	492	14	as	as	IN
cord-270892-ycc3csyh	492	15	type	type	NN
cord-270892-ycc3csyh	492	16	I	-PRON-	PRP
cord-270892-ycc3csyh	492	17	interferons	interferon	NNS
cord-270892-ycc3csyh	492	18	and	and	CC
cord-270892-ycc3csyh	492	19	nitric	nitric	NN
cord-270892-ycc3csyh	492	20	oxide	oxide	NN
cord-270892-ycc3csyh	492	21	,	,	,
cord-270892-ycc3csyh	492	22	and	and	CC
cord-270892-ycc3csyh	492	23	produce	produce	VB
cord-270892-ycc3csyh	492	24	cytokines	cytokine	NNS
cord-270892-ycc3csyh	492	25	and	and	CC
cord-270892-ycc3csyh	492	26	chemokines	chemokine	NNS
cord-270892-ycc3csyh	492	27	that	that	WDT
cord-270892-ycc3csyh	492	28	influence	influence	VBP
cord-270892-ycc3csyh	492	29	the	the	DT
cord-270892-ycc3csyh	492	30	subsequent	subsequent	JJ
cord-270892-ycc3csyh	492	31	induced	induce	VBN
cord-270892-ycc3csyh	492	32	innate	innate	JJ
cord-270892-ycc3csyh	492	33	-	-	HYPH
cord-270892-ycc3csyh	492	34	and	and	CC
cord-270892-ycc3csyh	492	35	specific	specific	JJ
cord-270892-ycc3csyh	492	36	-	-	HYPH
cord-270892-ycc3csyh	492	37	immune	immune	JJ
cord-270892-ycc3csyh	492	38	response	response	NN
cord-270892-ycc3csyh	492	39	.	.	.
cord-270892-ycc3csyh	493	1	These	these	DT
cord-270892-ycc3csyh	493	2	processes	process	NNS
cord-270892-ycc3csyh	493	3	are	be	VBP
cord-270892-ycc3csyh	493	4	beneficial	beneficial	JJ
cord-270892-ycc3csyh	493	5	in	in	IN
cord-270892-ycc3csyh	493	6	facilitating	facilitate	VBG
cord-270892-ycc3csyh	493	7	clearance	clearance	NN
cord-270892-ycc3csyh	493	8	of	of	IN
cord-270892-ycc3csyh	493	9	virus	virus	NN
cord-270892-ycc3csyh	493	10	from	from	IN
cord-270892-ycc3csyh	493	11	the	the	DT
cord-270892-ycc3csyh	493	12	respiratory	respiratory	JJ
cord-270892-ycc3csyh	493	13	tract	tract	NN
cord-270892-ycc3csyh	493	14	,	,	,
cord-270892-ycc3csyh	493	15	but	but	CC
cord-270892-ycc3csyh	493	16	also	also	RB
cord-270892-ycc3csyh	493	17	cause	cause	VB
cord-270892-ycc3csyh	493	18	immuno	immuno	JJ
cord-270892-ycc3csyh	493	19	-	-	HYPH
cord-270892-ycc3csyh	493	20	pathology	pathology	NN
cord-270892-ycc3csyh	493	21	.	.	.
cord-270892-ycc3csyh	494	1	Following	follow	VBG
cord-270892-ycc3csyh	494	2	HRV	HRV	NNP
cord-270892-ycc3csyh	494	3	-	-	HYPH
cord-270892-ycc3csyh	494	4	infection	infection	NN
cord-270892-ycc3csyh	494	5	,	,	,
cord-270892-ycc3csyh	494	6	disease	disease	NN
cord-270892-ycc3csyh	494	7	severity	severity	NN
cord-270892-ycc3csyh	494	8	is	be	VBZ
cord-270892-ycc3csyh	494	9	dependent	dependent	JJ
cord-270892-ycc3csyh	494	10	on	on	IN
cord-270892-ycc3csyh	494	11	direct	direct	JJ
cord-270892-ycc3csyh	494	12	,	,	,
cord-270892-ycc3csyh	494	13	harmful	harmful	JJ
cord-270892-ycc3csyh	494	14	effects	effect	NNS
cord-270892-ycc3csyh	494	15	of	of	IN
cord-270892-ycc3csyh	494	16	the	the	DT
cord-270892-ycc3csyh	494	17	virus	virus	NN
cord-270892-ycc3csyh	494	18	as	as	RB
cord-270892-ycc3csyh	494	19	well	well	RB
cord-270892-ycc3csyh	494	20	as	as	IN
cord-270892-ycc3csyh	494	21	tissue	tissue	NN
cord-270892-ycc3csyh	494	22	damage	damage	NN
cord-270892-ycc3csyh	494	23	as	as	IN
cord-270892-ycc3csyh	494	24	a	a	DT
cord-270892-ycc3csyh	494	25	result	result	NN
cord-270892-ycc3csyh	494	26	of	of	IN
cord-270892-ycc3csyh	494	27	the	the	DT
cord-270892-ycc3csyh	494	28	host	host	NN
cord-270892-ycc3csyh	494	29	antiviral	antiviral	JJ
cord-270892-ycc3csyh	494	30	immune	immune	JJ
cord-270892-ycc3csyh	494	31	response	response	NN
cord-270892-ycc3csyh	494	32	.	.	.
cord-270892-ycc3csyh	495	1	Accordingly	accordingly	RB
cord-270892-ycc3csyh	495	2	,	,	,
cord-270892-ycc3csyh	495	3	a	a	DT
cord-270892-ycc3csyh	495	4	number	number	NN
cord-270892-ycc3csyh	495	5	of	of	IN
cord-270892-ycc3csyh	495	6	agents	agent	NNS
cord-270892-ycc3csyh	495	7	with	with	IN
cord-270892-ycc3csyh	495	8	phenomenological	phenomenological	JJ
cord-270892-ycc3csyh	495	9	effects	effect	NNS
cord-270892-ycc3csyh	495	10	against	against	IN
cord-270892-ycc3csyh	495	11	common	common	JJ
cord-270892-ycc3csyh	495	12	cold	cold	NN
cord-270892-ycc3csyh	495	13	have	have	VBP
cord-270892-ycc3csyh	495	14	shown	show	VBN
cord-270892-ycc3csyh	495	15	to	to	TO
cord-270892-ycc3csyh	495	16	exert	exert	VB
cord-270892-ycc3csyh	495	17	their	-PRON-	PRP$
cord-270892-ycc3csyh	495	18	activity	activity	NN
cord-270892-ycc3csyh	495	19	more	more	RBR
cord-270892-ycc3csyh	495	20	in	in	IN
cord-270892-ycc3csyh	495	21	the	the	DT
cord-270892-ycc3csyh	495	22	field	field	NN
cord-270892-ycc3csyh	495	23	of	of	IN
cord-270892-ycc3csyh	495	24	regenerating	regenerate	VBG
cord-270892-ycc3csyh	495	25	tissue	tissue	NN
cord-270892-ycc3csyh	495	26	damage	damage	NN
cord-270892-ycc3csyh	495	27	than	than	IN
cord-270892-ycc3csyh	495	28	on	on	IN
cord-270892-ycc3csyh	495	29	a	a	DT
cord-270892-ycc3csyh	495	30	direct	direct	JJ
cord-270892-ycc3csyh	495	31	anti	anti	JJ
cord-270892-ycc3csyh	495	32	-	-	JJ
cord-270892-ycc3csyh	495	33	HRV	HRV	NNP
cord-270892-ycc3csyh	495	34	effect	effect	NN
cord-270892-ycc3csyh	495	35	.	.	.
cord-270892-ycc3csyh	496	1	Several	several	JJ
cord-270892-ycc3csyh	496	2	herbal	herbal	JJ
cord-270892-ycc3csyh	496	3	remedies	remedy	NNS
cord-270892-ycc3csyh	496	4	consisting	consist	VBG
cord-270892-ycc3csyh	496	5	of	of	IN
cord-270892-ycc3csyh	496	6	a	a	DT
cord-270892-ycc3csyh	496	7	multitude	multitude	NN
cord-270892-ycc3csyh	496	8	of	of	IN
cord-270892-ycc3csyh	496	9	secondary	secondary	JJ
cord-270892-ycc3csyh	496	10	metabolites	metabolite	NNS
cord-270892-ycc3csyh	496	11	from	from	IN
cord-270892-ycc3csyh	496	12	different	different	JJ
cord-270892-ycc3csyh	496	13	chemical	chemical	NN
cord-270892-ycc3csyh	496	14	classes	class	NNS
cord-270892-ycc3csyh	496	15	may	may	MD
cord-270892-ycc3csyh	496	16	attribute	attribute	VB
cord-270892-ycc3csyh	496	17	in	in	IN
cord-270892-ycc3csyh	496	18	a	a	DT
cord-270892-ycc3csyh	496	19	beneficial	beneficial	JJ
cord-270892-ycc3csyh	496	20	way	way	NN
cord-270892-ycc3csyh	496	21	for	for	IN
cord-270892-ycc3csyh	496	22	the	the	DT
cord-270892-ycc3csyh	496	23	treatment	treatment	NN
cord-270892-ycc3csyh	496	24	of	of	IN
cord-270892-ycc3csyh	496	25	common	common	JJ
cord-270892-ycc3csyh	496	26	cold	cold	NN
cord-270892-ycc3csyh	496	27	by	by	IN
cord-270892-ycc3csyh	496	28	reducing	reduce	VBG
cord-270892-ycc3csyh	496	29	symptom	symptom	NN
cord-270892-ycc3csyh	496	30	severity	severity	NN
cord-270892-ycc3csyh	496	31	and	and	CC
cord-270892-ycc3csyh	496	32	duration	duration	NN
cord-270892-ycc3csyh	496	33	due	due	IN
cord-270892-ycc3csyh	496	34	to	to	IN
cord-270892-ycc3csyh	496	35	their	-PRON-	PRP$
cord-270892-ycc3csyh	496	36	immune	immune	NN
cord-270892-ycc3csyh	496	37	-	-	HYPH
cord-270892-ycc3csyh	496	38	modulating	modulate	VBG
cord-270892-ycc3csyh	496	39	,	,	,
cord-270892-ycc3csyh	496	40	anti	anti	JJ
cord-270892-ycc3csyh	496	41	-	-	JJ
cord-270892-ycc3csyh	496	42	oxidative	oxidative	JJ
cord-270892-ycc3csyh	496	43	,	,	,
cord-270892-ycc3csyh	496	44	and	and	CC
cord-270892-ycc3csyh	496	45	anti	anti	JJ
cord-270892-ycc3csyh	496	46	-	-	JJ
cord-270892-ycc3csyh	496	47	inflammatory	inflammatory	JJ
cord-270892-ycc3csyh	496	48	properties	property	NNS
cord-270892-ycc3csyh	496	49	.	.	.
cord-270892-ycc3csyh	497	1	Beside	beside	IN
cord-270892-ycc3csyh	497	2	these	these	DT
cord-270892-ycc3csyh	497	3	commonly	commonly	RB
cord-270892-ycc3csyh	497	4	observed	observe	VBD
cord-270892-ycc3csyh	497	5	bioactivities	bioactivitie	NNS
cord-270892-ycc3csyh	497	6	of	of	IN
cord-270892-ycc3csyh	497	7	natural	natural	JJ
cord-270892-ycc3csyh	497	8	products	product	NNS
cord-270892-ycc3csyh	497	9	,	,	,
cord-270892-ycc3csyh	497	10	multicomponent	multicomponent	NN
cord-270892-ycc3csyh	497	11	mixtures	mixture	NNS
cord-270892-ycc3csyh	497	12	like	like	IN
cord-270892-ycc3csyh	497	13	botanicals	botanical	NNS
cord-270892-ycc3csyh	497	14	often	often	RB
cord-270892-ycc3csyh	497	15	show	show	VBP
cord-270892-ycc3csyh	497	16	overlapping	overlap	VBG
cord-270892-ycc3csyh	497	17	symptomatic	symptomatic	JJ
cord-270892-ycc3csyh	497	18	effects	effect	NNS
cord-270892-ycc3csyh	497	19	as	as	RB
cord-270892-ycc3csyh	497	20	well	well	RB
cord-270892-ycc3csyh	497	21	as	as	IN
cord-270892-ycc3csyh	497	22	synergistic	synergistic	JJ
cord-270892-ycc3csyh	497	23	and/or	and/or	CC
cord-270892-ycc3csyh	497	24	additive	additive	NN
cord-270892-ycc3csyh	497	25	properties	property	NNS
cord-270892-ycc3csyh	497	26	.	.	.
cord-270892-ycc3csyh	498	1	Thus	thus	RB
cord-270892-ycc3csyh	498	2	,	,	,
cord-270892-ycc3csyh	498	3	it	-PRON-	PRP
cord-270892-ycc3csyh	498	4	is	be	VBZ
cord-270892-ycc3csyh	498	5	a	a	DT
cord-270892-ycc3csyh	498	6	challenging	challenging	JJ
cord-270892-ycc3csyh	498	7	endeavor	endeavor	NN
cord-270892-ycc3csyh	498	8	to	to	TO
cord-270892-ycc3csyh	498	9	track	track	VB
cord-270892-ycc3csyh	498	10	down	down	RP
cord-270892-ycc3csyh	498	11	an	an	DT
cord-270892-ycc3csyh	498	12	observed	observed	JJ
cord-270892-ycc3csyh	498	13	phenomenological	phenomenological	JJ
cord-270892-ycc3csyh	498	14	effect	effect	NN
cord-270892-ycc3csyh	498	15	of	of	IN
cord-270892-ycc3csyh	498	16	a	a	DT
cord-270892-ycc3csyh	498	17	complex	complex	JJ
cord-270892-ycc3csyh	498	18	mixture	mixture	NN
cord-270892-ycc3csyh	498	19	on	on	IN
cord-270892-ycc3csyh	498	20	a	a	DT
cord-270892-ycc3csyh	498	21	molecular	molecular	JJ
cord-270892-ycc3csyh	498	22	level	level	NN
cord-270892-ycc3csyh	498	23	.	.	.
cord-270892-ycc3csyh	499	1	The	the	DT
cord-270892-ycc3csyh	499	2	following	follow	VBG
cord-270892-ycc3csyh	499	3	section	section	NN
cord-270892-ycc3csyh	499	4	explores	explore	VBZ
cord-270892-ycc3csyh	499	5	the	the	DT
cord-270892-ycc3csyh	499	6	significance	significance	NN
cord-270892-ycc3csyh	499	7	and	and	CC
cord-270892-ycc3csyh	499	8	current	current	JJ
cord-270892-ycc3csyh	499	9	knowledge	knowledge	NN
cord-270892-ycc3csyh	499	10	of	of	IN
cord-270892-ycc3csyh	499	11	selected	select	VBN
cord-270892-ycc3csyh	499	12	botanicals	botanical	NNS
cord-270892-ycc3csyh	499	13	for	for	IN
cord-270892-ycc3csyh	499	14	the	the	DT
cord-270892-ycc3csyh	499	15	prevention	prevention	NN
cord-270892-ycc3csyh	499	16	and	and	CC
cord-270892-ycc3csyh	499	17	therapy	therapy	NN
cord-270892-ycc3csyh	499	18	of	of	IN
cord-270892-ycc3csyh	499	19	common	common	JJ
cord-270892-ycc3csyh	499	20	cold	cold	NN
cord-270892-ycc3csyh	499	21	.	.	.
cord-270892-ycc3csyh	500	1	Questions	question	NNS
cord-270892-ycc3csyh	500	2	about	about	IN
cord-270892-ycc3csyh	500	3	(	(	-LRB-
cord-270892-ycc3csyh	500	4	1	1	CD
cord-270892-ycc3csyh	500	5	)	)	-RRB-
cord-270892-ycc3csyh	500	6	clinical	clinical	JJ
cord-270892-ycc3csyh	500	7	evidence	evidence	NN
cord-270892-ycc3csyh	500	8	of	of	IN
cord-270892-ycc3csyh	500	9	efficacy	efficacy	NN
cord-270892-ycc3csyh	500	10	,	,	,
cord-270892-ycc3csyh	500	11	(	(	-LRB-
cord-270892-ycc3csyh	500	12	2	2	LS
cord-270892-ycc3csyh	500	13	)	)	-RRB-
cord-270892-ycc3csyh	500	14	the	the	DT
cord-270892-ycc3csyh	500	15	constituents	constituent	NNS
cord-270892-ycc3csyh	500	16	or	or	CC
cord-270892-ycc3csyh	500	17	at	at	IN
cord-270892-ycc3csyh	500	18	least	least	JJS
cord-270892-ycc3csyh	500	19	the	the	DT
cord-270892-ycc3csyh	500	20	chemical	chemical	NN
cord-270892-ycc3csyh	500	21	classes	class	NNS
cord-270892-ycc3csyh	500	22	that	that	WDT
cord-270892-ycc3csyh	500	23	are	be	VBP
cord-270892-ycc3csyh	500	24	involved	involve	VBN
cord-270892-ycc3csyh	500	25	in	in	IN
cord-270892-ycc3csyh	500	26	the	the	DT
cord-270892-ycc3csyh	500	27	observed	observed	JJ
cord-270892-ycc3csyh	500	28	anti	anti	JJ
cord-270892-ycc3csyh	500	29	-	-	JJ
cord-270892-ycc3csyh	500	30	HRV	HRV	NNP
cord-270892-ycc3csyh	500	31	effect	effect	NN
cord-270892-ycc3csyh	500	32	,	,	,
cord-270892-ycc3csyh	500	33	and	and	CC
cord-270892-ycc3csyh	500	34	(	(	-LRB-
cord-270892-ycc3csyh	500	35	3	3	LS
cord-270892-ycc3csyh	500	36	)	)	-RRB-
cord-270892-ycc3csyh	500	37	the	the	DT
cord-270892-ycc3csyh	500	38	involved	involved	JJ
cord-270892-ycc3csyh	500	39	pharmacological	pharmacological	JJ
cord-270892-ycc3csyh	500	40	targets	target	NNS
cord-270892-ycc3csyh	500	41	were	be	VBD
cord-270892-ycc3csyh	500	42	covered	cover	VBN
cord-270892-ycc3csyh	500	43	as	as	RB
cord-270892-ycc3csyh	500	44	far	far	RB
cord-270892-ycc3csyh	500	45	as	as	IN
cord-270892-ycc3csyh	500	46	possible	possible	JJ
cord-270892-ycc3csyh	500	47	.	.	.
cord-270892-ycc3csyh	501	1	Echinacea	echinacea	NN
cord-270892-ycc3csyh	501	2	preparations	preparation	NNS
cord-270892-ycc3csyh	501	3	include	include	VBP
cord-270892-ycc3csyh	501	4	expressed	express	VBD
cord-270892-ycc3csyh	501	5	juice	juice	NN
cord-270892-ycc3csyh	501	6	from	from	IN
cord-270892-ycc3csyh	501	7	aerial	aerial	JJ
cord-270892-ycc3csyh	501	8	parts	part	NNS
cord-270892-ycc3csyh	501	9	as	as	RB
cord-270892-ycc3csyh	501	10	well	well	RB
cord-270892-ycc3csyh	501	11	as	as	IN
cord-270892-ycc3csyh	501	12	extracts	extract	NNS
cord-270892-ycc3csyh	501	13	of	of	IN
cord-270892-ycc3csyh	501	14	roots	root	NNS
cord-270892-ycc3csyh	501	15	or	or	CC
cord-270892-ycc3csyh	501	16	aerial	aerial	JJ
cord-270892-ycc3csyh	501	17	parts	part	NNS
cord-270892-ycc3csyh	501	18	,	,	,
cord-270892-ycc3csyh	501	19	or	or	CC
cord-270892-ycc3csyh	501	20	both	both	DT
cord-270892-ycc3csyh	501	21	,	,	,
cord-270892-ycc3csyh	501	22	from	from	IN
cord-270892-ycc3csyh	501	23	one	one	CD
cord-270892-ycc3csyh	501	24	or	or	CC
cord-270892-ycc3csyh	501	25	more	more	JJR
cord-270892-ycc3csyh	501	26	species	specie	NNS
cord-270892-ycc3csyh	501	27	of	of	IN
cord-270892-ycc3csyh	501	28	the	the	DT
cord-270892-ycc3csyh	501	29	genus	genus	NN
cord-270892-ycc3csyh	501	30	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	501	31	(	(	-LRB-
cord-270892-ycc3csyh	501	32	E.	E.	NNP
cord-270892-ycc3csyh	501	33	angustifolia	angustifolia	NNP
cord-270892-ycc3csyh	501	34	,	,	,
cord-270892-ycc3csyh	501	35	E.	E.	NNP
cord-270892-ycc3csyh	501	36	purpurea	purpurea	NN
cord-270892-ycc3csyh	501	37	,	,	,
cord-270892-ycc3csyh	501	38	and	and	CC
cord-270892-ycc3csyh	501	39	E.	E.	NNP
cord-270892-ycc3csyh	501	40	pallida	pallida	NNP
cord-270892-ycc3csyh	501	41	)	)	-RRB-
cord-270892-ycc3csyh	501	42	.	.	.
cord-270892-ycc3csyh	502	1	They	-PRON-	PRP
cord-270892-ycc3csyh	502	2	are	be	VBP
cord-270892-ycc3csyh	502	3	the	the	DT
cord-270892-ycc3csyh	502	4	most	most	RBS
cord-270892-ycc3csyh	502	5	recognized	recognize	VBN
cord-270892-ycc3csyh	502	6	botanicals	botanical	NNS
cord-270892-ycc3csyh	502	7	for	for	IN
cord-270892-ycc3csyh	502	8	prevention	prevention	NN
cord-270892-ycc3csyh	502	9	and	and	CC
cord-270892-ycc3csyh	502	10	treatment	treatment	NN
cord-270892-ycc3csyh	502	11	of	of	IN
cord-270892-ycc3csyh	502	12	common	common	JJ
cord-270892-ycc3csyh	502	13	cold	cold	NN
cord-270892-ycc3csyh	502	14	and	and	CC
cord-270892-ycc3csyh	502	15	flu	flu	NN
cord-270892-ycc3csyh	502	16	,	,	,
cord-270892-ycc3csyh	502	17	and	and	CC
cord-270892-ycc3csyh	502	18	account	account	VBP
cord-270892-ycc3csyh	502	19	for	for	IN
cord-270892-ycc3csyh	502	20	the	the	DT
cord-270892-ycc3csyh	502	21	second	second	JJ
cord-270892-ycc3csyh	502	22	top	top	RB
cord-270892-ycc3csyh	502	23	-	-	HYPH
cord-270892-ycc3csyh	502	24	selling	sell	VBG
cord-270892-ycc3csyh	502	25	herbal	herbal	JJ
cord-270892-ycc3csyh	502	26	products	product	NNS
cord-270892-ycc3csyh	502	27	in	in	IN
cord-270892-ycc3csyh	502	28	the	the	DT
cord-270892-ycc3csyh	502	29	US	US	NNP
cord-270892-ycc3csyh	502	30	-	-	HYPH
cord-270892-ycc3csyh	502	31	market	market	NN
cord-270892-ycc3csyh	502	32	.	.	.
cord-270892-ycc3csyh	503	1	278	278	CD
cord-270892-ycc3csyh	504	1	Accordingly	accordingly	RB
cord-270892-ycc3csyh	504	2	,	,	,
cord-270892-ycc3csyh	504	3	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	504	4	has	have	VBZ
cord-270892-ycc3csyh	504	5	come	come	VBN
cord-270892-ycc3csyh	504	6	under	under	IN
cord-270892-ycc3csyh	504	7	much	much	JJ
cord-270892-ycc3csyh	504	8	scientific	scientific	JJ
cord-270892-ycc3csyh	504	9	scrutiny	scrutiny	NN
cord-270892-ycc3csyh	504	10	.	.	.
cord-270892-ycc3csyh	505	1	The	the	DT
cord-270892-ycc3csyh	505	2	high	high	JJ
cord-270892-ycc3csyh	505	3	number	number	NN
cord-270892-ycc3csyh	505	4	of	of	IN
cord-270892-ycc3csyh	505	5	studies	study	NNS
cord-270892-ycc3csyh	505	6	dealing	deal	VBG
cord-270892-ycc3csyh	505	7	with	with	IN
cord-270892-ycc3csyh	505	8	the	the	DT
cord-270892-ycc3csyh	505	9	effectiveness	effectiveness	NN
cord-270892-ycc3csyh	505	10	of	of	IN
cord-270892-ycc3csyh	505	11	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	505	12	for	for	IN
cord-270892-ycc3csyh	505	13	preventing	prevent	VBG
cord-270892-ycc3csyh	505	14	and	and	CC
cord-270892-ycc3csyh	505	15	treating	treat	VBG
cord-270892-ycc3csyh	505	16	the	the	DT
cord-270892-ycc3csyh	505	17	common	common	JJ
cord-270892-ycc3csyh	505	18	cold	cold	NN
cord-270892-ycc3csyh	505	19	from	from	IN
cord-270892-ycc3csyh	505	20	clinical	clinical	JJ
cord-270892-ycc3csyh	505	21	trials	trial	NNS
cord-270892-ycc3csyh	505	22	was	be	VBD
cord-270892-ycc3csyh	505	23	recently	recently	RB
cord-270892-ycc3csyh	505	24	reviewed	review	VBN
cord-270892-ycc3csyh	505	25	by	by	IN
cord-270892-ycc3csyh	505	26	Woelkart	Woelkart	NNP
cord-270892-ycc3csyh	505	27	et	et	NNP
cord-270892-ycc3csyh	505	28	al	al	NNP
cord-270892-ycc3csyh	505	29	.	.	.
cord-270892-ycc3csyh	506	1	279	279	CD
cord-270892-ycc3csyh	507	1	The	the	DT
cord-270892-ycc3csyh	507	2	authors	author	NNS
cord-270892-ycc3csyh	507	3	summarized	summarize	VBD
cord-270892-ycc3csyh	507	4	the	the	DT
cord-270892-ycc3csyh	507	5	findings	finding	NNS
cord-270892-ycc3csyh	507	6	of	of	IN
cord-270892-ycc3csyh	507	7	the	the	DT
cord-270892-ycc3csyh	507	8	meta	meta	NNP
cord-270892-ycc3csyh	507	9	-	-	HYPH
cord-270892-ycc3csyh	507	10	analyses	analysis	NNS
cord-270892-ycc3csyh	507	11	regarding	regard	VBG
cord-270892-ycc3csyh	507	12	the	the	DT
cord-270892-ycc3csyh	507	13	16	16	CD
cord-270892-ycc3csyh	507	14	randomized	randomized	JJ
cord-270892-ycc3csyh	507	15	controlled	control	VBN
cord-270892-ycc3csyh	507	16	trials	trial	NNS
cord-270892-ycc3csyh	507	17	evaluated	evaluate	VBN
cord-270892-ycc3csyh	507	18	in	in	IN
cord-270892-ycc3csyh	507	19	the	the	DT
cord-270892-ycc3csyh	507	20	Cochrane	Cochrane	NNP
cord-270892-ycc3csyh	507	21	database	database	NN
cord-270892-ycc3csyh	507	22	,	,	,
cord-270892-ycc3csyh	507	23	280	280	CD
cord-270892-ycc3csyh	507	24	the	the	DT
cord-270892-ycc3csyh	507	25	14	14	CD
cord-270892-ycc3csyh	507	26	randomized	randomized	JJ
cord-270892-ycc3csyh	507	27	clinical	clinical	JJ
cord-270892-ycc3csyh	507	28	trials	trial	NNS
cord-270892-ycc3csyh	507	29	analyzed	analyze	VBN
cord-270892-ycc3csyh	507	30	by	by	IN
cord-270892-ycc3csyh	507	31	Shah	Shah	NNP
cord-270892-ycc3csyh	507	32	et	et	NNP
cord-270892-ycc3csyh	507	33	al	al	NNP
cord-270892-ycc3csyh	507	34	.	.	NNP
cord-270892-ycc3csyh	507	35	,	,	,
cord-270892-ycc3csyh	507	36	281	281	CD
cord-270892-ycc3csyh	507	37	and	and	CC
cord-270892-ycc3csyh	507	38	the	the	DT
cord-270892-ycc3csyh	507	39	experimental	experimental	JJ
cord-270892-ycc3csyh	507	40	HRV	HRV	NNP
cord-270892-ycc3csyh	507	41	-	-	HYPH
cord-270892-ycc3csyh	507	42	infection	infection	NN
cord-270892-ycc3csyh	507	43	studies	study	NNS
cord-270892-ycc3csyh	507	44	pooled	pool	VBN
cord-270892-ycc3csyh	507	45	by	by	IN
cord-270892-ycc3csyh	507	46	Schoop	Schoop	NNP
cord-270892-ycc3csyh	507	47	et	et	NNP
cord-270892-ycc3csyh	507	48	al	al	NNP
cord-270892-ycc3csyh	507	49	.	.	.
cord-270892-ycc3csyh	508	1	282	282	CD
cord-270892-ycc3csyh	509	1	To	to	TO
cord-270892-ycc3csyh	509	2	sum	sum	VB
cord-270892-ycc3csyh	509	3	up	up	RP
cord-270892-ycc3csyh	509	4	,	,	,
cord-270892-ycc3csyh	509	5	the	the	DT
cord-270892-ycc3csyh	509	6	clinical	clinical	JJ
cord-270892-ycc3csyh	509	7	data	datum	NNS
cord-270892-ycc3csyh	509	8	on	on	IN
cord-270892-ycc3csyh	509	9	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	509	10	so	so	RB
cord-270892-ycc3csyh	509	11	far	far	RB
cord-270892-ycc3csyh	509	12	are	be	VBP
cord-270892-ycc3csyh	509	13	not	not	RB
cord-270892-ycc3csyh	509	14	fully	fully	RB
cord-270892-ycc3csyh	509	15	consistent	consistent	JJ
cord-270892-ycc3csyh	509	16	,	,	,
cord-270892-ycc3csyh	509	17	mainly	mainly	RB
cord-270892-ycc3csyh	509	18	based	base	VBN
cord-270892-ycc3csyh	509	19	on	on	IN
cord-270892-ycc3csyh	509	20	problems	problem	NNS
cord-270892-ycc3csyh	509	21	inherent	inherent	JJ
cord-270892-ycc3csyh	509	22	in	in	IN
cord-270892-ycc3csyh	509	23	assessing	assess	VBG
cord-270892-ycc3csyh	509	24	the	the	DT
cord-270892-ycc3csyh	509	25	efficacy	efficacy	NN
cord-270892-ycc3csyh	509	26	of	of	IN
cord-270892-ycc3csyh	509	27	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	509	28	preparations	preparation	NNS
cord-270892-ycc3csyh	509	29	,	,	,
cord-270892-ycc3csyh	509	30	such	such	JJ
cord-270892-ycc3csyh	509	31	as	as	IN
cord-270892-ycc3csyh	509	32	lack	lack	NN
cord-270892-ycc3csyh	509	33	of	of	IN
cord-270892-ycc3csyh	509	34	comparability	comparability	NN
cord-270892-ycc3csyh	509	35	of	of	IN
cord-270892-ycc3csyh	509	36	available	available	JJ
cord-270892-ycc3csyh	509	37	preparations	preparation	NNS
cord-270892-ycc3csyh	509	38	,	,	,
cord-270892-ycc3csyh	509	39	study	study	NN
cord-270892-ycc3csyh	509	40	design	design	NN
cord-270892-ycc3csyh	509	41	,	,	,
cord-270892-ycc3csyh	509	42	and	and	CC
cord-270892-ycc3csyh	509	43	outcome	outcome	NN
cord-270892-ycc3csyh	509	44	.	.	.
cord-270892-ycc3csyh	510	1	Nevertheless	nevertheless	RB
cord-270892-ycc3csyh	510	2	,	,	,
cord-270892-ycc3csyh	510	3	the	the	DT
cord-270892-ycc3csyh	510	4	meta	meta	NNP
cord-270892-ycc3csyh	510	5	-	-	HYPH
cord-270892-ycc3csyh	510	6	analyses	analysis	NNS
cord-270892-ycc3csyh	510	7	showed	show	VBD
cord-270892-ycc3csyh	510	8	some	some	DT
cord-270892-ycc3csyh	510	9	evidence	evidence	NN
cord-270892-ycc3csyh	510	10	that	that	IN
cord-270892-ycc3csyh	510	11	preparations	preparation	NNS
cord-270892-ycc3csyh	510	12	based	base	VBN
cord-270892-ycc3csyh	510	13	on	on	IN
cord-270892-ycc3csyh	510	14	the	the	DT
cord-270892-ycc3csyh	510	15	aerial	aerial	JJ
cord-270892-ycc3csyh	510	16	parts	part	NNS
cord-270892-ycc3csyh	510	17	of	of	IN
cord-270892-ycc3csyh	510	18	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	510	19	purpurea	purpurea	NN
cord-270892-ycc3csyh	510	20	might	may	MD
cord-270892-ycc3csyh	510	21	be	be	VB
cord-270892-ycc3csyh	510	22	effective	effective	JJ
cord-270892-ycc3csyh	510	23	for	for	IN
cord-270892-ycc3csyh	510	24	the	the	DT
cord-270892-ycc3csyh	510	25	early	early	JJ
cord-270892-ycc3csyh	510	26	treatment	treatment	NN
cord-270892-ycc3csyh	510	27	of	of	IN
cord-270892-ycc3csyh	510	28	colds	cold	NNS
cord-270892-ycc3csyh	510	29	in	in	IN
cord-270892-ycc3csyh	510	30	adults	adult	NNS
cord-270892-ycc3csyh	510	31	.	.	.
cord-270892-ycc3csyh	511	1	280	280	CD
cord-270892-ycc3csyh	511	2	Echinacea	Echinacea	NNS
cord-270892-ycc3csyh	511	3	showed	show	VBD
cord-270892-ycc3csyh	511	4	to	to	TO
cord-270892-ycc3csyh	511	5	decrease	decrease	VB
cord-270892-ycc3csyh	511	6	the	the	DT
cord-270892-ycc3csyh	511	7	odds	odd	NNS
cord-270892-ycc3csyh	511	8	of	of	IN
cord-270892-ycc3csyh	511	9	developing	develop	VBG
cord-270892-ycc3csyh	511	10	the	the	DT
cord-270892-ycc3csyh	511	11	common	common	JJ
cord-270892-ycc3csyh	511	12	cold	cold	NN
cord-270892-ycc3csyh	511	13	by	by	IN
cord-270892-ycc3csyh	511	14	58	58	CD
cord-270892-ycc3csyh	511	15	%	%	NN
cord-270892-ycc3csyh	511	16	and	and	CC
cord-270892-ycc3csyh	511	17	the	the	DT
cord-270892-ycc3csyh	511	18	duration	duration	NN
cord-270892-ycc3csyh	511	19	of	of	IN
cord-270892-ycc3csyh	511	20	a	a	DT
cord-270892-ycc3csyh	511	21	cold	cold	NN
cord-270892-ycc3csyh	511	22	by	by	IN
cord-270892-ycc3csyh	511	23	1.4	1.4	CD
cord-270892-ycc3csyh	511	24	days	day	NNS
cord-270892-ycc3csyh	511	25	.	.	.
cord-270892-ycc3csyh	512	1	281	281	CD
cord-270892-ycc3csyh	513	1	Similarly	similarly	RB
cord-270892-ycc3csyh	513	2	,	,	,
cord-270892-ycc3csyh	513	3	the	the	DT
cord-270892-ycc3csyh	513	4	evaluation	evaluation	NN
cord-270892-ycc3csyh	513	5	of	of	IN
cord-270892-ycc3csyh	513	6	three	three	CD
cord-270892-ycc3csyh	513	7	induced	induce	VBN
cord-270892-ycc3csyh	513	8	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	513	9	prevention	prevention	NN
cord-270892-ycc3csyh	513	10	studies	study	NNS
cord-270892-ycc3csyh	513	11	revealed	reveal	VBD
cord-270892-ycc3csyh	513	12	the	the	DT
cord-270892-ycc3csyh	513	13	odds	odd	NNS
cord-270892-ycc3csyh	513	14	of	of	IN
cord-270892-ycc3csyh	513	15	experiencing	experience	VBG
cord-270892-ycc3csyh	513	16	a	a	DT
cord-270892-ycc3csyh	513	17	clinical	clinical	JJ
cord-270892-ycc3csyh	513	18	cold	cold	NN
cord-270892-ycc3csyh	513	19	were	be	VBD
cord-270892-ycc3csyh	513	20	55	55	CD
cord-270892-ycc3csyh	513	21	%	%	NN
cord-270892-ycc3csyh	513	22	higher	high	JJR
cord-270892-ycc3csyh	513	23	with	with	IN
cord-270892-ycc3csyh	513	24	placebo	placebo	NN
cord-270892-ycc3csyh	513	25	than	than	IN
cord-270892-ycc3csyh	513	26	with	with	IN
cord-270892-ycc3csyh	513	27	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	513	28	.	.	.
cord-270892-ycc3csyh	514	1	282	282	CD
cord-270892-ycc3csyh	515	1	Stepping	step	VBG
cord-270892-ycc3csyh	515	2	into	into	IN
cord-270892-ycc3csyh	515	3	a	a	DT
cord-270892-ycc3csyh	515	4	molecular	molecular	JJ
cord-270892-ycc3csyh	515	5	level	level	NN
cord-270892-ycc3csyh	515	6	,	,	,
cord-270892-ycc3csyh	515	7	several	several	JJ
cord-270892-ycc3csyh	515	8	constituents	constituent	NNS
cord-270892-ycc3csyh	515	9	found	find	VBN
cord-270892-ycc3csyh	515	10	in	in	IN
cord-270892-ycc3csyh	515	11	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	515	12	species	specie	NNS
cord-270892-ycc3csyh	515	13	could	could	MD
cord-270892-ycc3csyh	515	14	potentially	potentially	RB
cord-270892-ycc3csyh	515	15	affect	affect	VB
cord-270892-ycc3csyh	515	16	the	the	DT
cord-270892-ycc3csyh	515	17	symptoms	symptom	NNS
cord-270892-ycc3csyh	515	18	of	of	IN
cord-270892-ycc3csyh	515	19	common	common	JJ
cord-270892-ycc3csyh	515	20	cold	cold	NN
cord-270892-ycc3csyh	515	21	.	.	.
cord-270892-ycc3csyh	516	1	Chemically	chemically	RB
cord-270892-ycc3csyh	516	2	identified	identify	VBN
cord-270892-ycc3csyh	516	3	substances	substance	NNS
cord-270892-ycc3csyh	516	4	include	include	VBP
cord-270892-ycc3csyh	516	5	polysaccharides	polysaccharide	NNS
cord-270892-ycc3csyh	516	6	and	and	CC
cord-270892-ycc3csyh	516	7	glycoproteins	glycoprotein	NNS
cord-270892-ycc3csyh	516	8	,	,	,
cord-270892-ycc3csyh	516	9	caffeic	caffeic	NN
cord-270892-ycc3csyh	516	10	acid	acid	NN
cord-270892-ycc3csyh	516	11	derivatives	derivative	NNS
cord-270892-ycc3csyh	516	12	(	(	-LRB-
cord-270892-ycc3csyh	516	13	especially	especially	RB
cord-270892-ycc3csyh	516	14	cichoric	cichoric	JJ
cord-270892-ycc3csyh	516	15	acid	acid	NN
cord-270892-ycc3csyh	516	16	and	and	CC
cord-270892-ycc3csyh	516	17	echinacoside	echinacoside	NN
cord-270892-ycc3csyh	516	18	)	)	-RRB-
cord-270892-ycc3csyh	516	19	,	,	,
cord-270892-ycc3csyh	516	20	and	and	CC
cord-270892-ycc3csyh	516	21	lipophilic	lipophilic	JJ
cord-270892-ycc3csyh	516	22	polyacetylenes	polyacetylene	NNS
cord-270892-ycc3csyh	516	23	and	and	CC
cord-270892-ycc3csyh	516	24	alkamides	alkamides	NNP
cord-270892-ycc3csyh	516	25	.	.	.
cord-270892-ycc3csyh	517	1	Pharmacological	pharmacological	JJ
cord-270892-ycc3csyh	517	2	studies	study	NNS
cord-270892-ycc3csyh	517	3	have	have	VBP
cord-270892-ycc3csyh	517	4	shown	show	VBN
cord-270892-ycc3csyh	517	5	that	that	RB
cord-270892-ycc3csyh	517	6	cichoric	cichoric	JJ
cord-270892-ycc3csyh	517	7	acid	acid	NN
cord-270892-ycc3csyh	517	8	,	,	,
cord-270892-ycc3csyh	517	9	alkamides	alkamides	NNP
cord-270892-ycc3csyh	517	10	,	,	,
cord-270892-ycc3csyh	517	11	glycoproteins	glycoprotein	NNS
cord-270892-ycc3csyh	517	12	,	,	,
cord-270892-ycc3csyh	517	13	and	and	CC
cord-270892-ycc3csyh	517	14	polysaccharides	polysaccharide	NNS
cord-270892-ycc3csyh	517	15	possess	possess	VBP
cord-270892-ycc3csyh	517	16	immunomodulatory	immunomodulatory	JJ
cord-270892-ycc3csyh	517	17	activity	activity	NN
cord-270892-ycc3csyh	517	18	.	.	.
cord-270892-ycc3csyh	518	1	Additionally	additionally	RB
cord-270892-ycc3csyh	518	2	,	,	,
cord-270892-ycc3csyh	518	3	alkamides	alkamide	NNS
cord-270892-ycc3csyh	518	4	have	have	VBP
cord-270892-ycc3csyh	518	5	been	be	VBN
cord-270892-ycc3csyh	518	6	reported	report	VBN
cord-270892-ycc3csyh	518	7	to	to	TO
cord-270892-ycc3csyh	518	8	exert	exert	VB
cord-270892-ycc3csyh	518	9	not	not	RB
cord-270892-ycc3csyh	518	10	only	only	RB
cord-270892-ycc3csyh	518	11	antiinflammatory	antiinflammatory	JJ
cord-270892-ycc3csyh	518	12	effects	effect	NNS
cord-270892-ycc3csyh	518	13	but	but	CC
cord-270892-ycc3csyh	518	14	also	also	RB
cord-270892-ycc3csyh	518	15	cannabinomimetic	cannabinomimetic	JJ
cord-270892-ycc3csyh	518	16	properties	property	NNS
cord-270892-ycc3csyh	518	17	,	,	,
cord-270892-ycc3csyh	518	18	which	which	WDT
cord-270892-ycc3csyh	518	19	are	be	VBP
cord-270892-ycc3csyh	518	20	suggested	suggest	VBN
cord-270892-ycc3csyh	518	21	as	as	IN
cord-270892-ycc3csyh	518	22	molecular	molecular	JJ
cord-270892-ycc3csyh	518	23	mode	mode	NN
cord-270892-ycc3csyh	518	24	of	of	IN
cord-270892-ycc3csyh	518	25	action	action	NN
cord-270892-ycc3csyh	518	26	of	of	IN
cord-270892-ycc3csyh	518	27	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	518	28	alkamides	alkamides	NNP
cord-270892-ycc3csyh	518	29	as	as	IN
cord-270892-ycc3csyh	518	30	immunomodulatory	immunomodulatory	JJ
cord-270892-ycc3csyh	518	31	agents	agent	NNS
cord-270892-ycc3csyh	518	32	.	.	.
cord-270892-ycc3csyh	519	1	283	283	CD
cord-270892-ycc3csyh	519	2	Raduner	Raduner	NNP
cord-270892-ycc3csyh	519	3	et	et	NNP
cord-270892-ycc3csyh	519	4	al	al	NNP
cord-270892-ycc3csyh	519	5	.	.	.
cord-270892-ycc3csyh	520	1	showed	show	VBD
cord-270892-ycc3csyh	520	2	that	that	IN
cord-270892-ycc3csyh	520	3	some	some	DT
cord-270892-ycc3csyh	520	4	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	520	5	alkamides	alkamide	NNS
cord-270892-ycc3csyh	520	6	exert	exert	VBP
cord-270892-ycc3csyh	520	7	cannabinoid	cannabinoid	NN
cord-270892-ycc3csyh	520	8	type	type	NN
cord-270892-ycc3csyh	520	9	2	2	CD
cord-270892-ycc3csyh	520	10	receptor	receptor	NN
cord-270892-ycc3csyh	520	11	-	-	HYPH
cord-270892-ycc3csyh	520	12	dependent	dependent	JJ
cord-270892-ycc3csyh	520	13	and	and	CC
cord-270892-ycc3csyh	520	14	independent	independent	JJ
cord-270892-ycc3csyh	520	15	immunomodulatory	immunomodulatory	JJ
cord-270892-ycc3csyh	520	16	effects	effect	NNS
cord-270892-ycc3csyh	520	17	on	on	IN
cord-270892-ycc3csyh	520	18	cytokine	cytokine	JJ
cord-270892-ycc3csyh	520	19	expression	expression	NN
cord-270892-ycc3csyh	520	20	.	.	.
cord-270892-ycc3csyh	521	1	284	284	CD
cord-270892-ycc3csyh	522	1	Different	different	JJ
cord-270892-ycc3csyh	522	2	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	522	3	constituents	constituent	NNS
cord-270892-ycc3csyh	522	4	were	be	VBD
cord-270892-ycc3csyh	522	5	evaluated	evaluate	VBN
cord-270892-ycc3csyh	522	6	for	for	IN
cord-270892-ycc3csyh	522	7	their	-PRON-	PRP$
cord-270892-ycc3csyh	522	8	anti	anti	JJ
cord-270892-ycc3csyh	522	9	-	-	JJ
cord-270892-ycc3csyh	522	10	oxidative	oxidative	JJ
cord-270892-ycc3csyh	522	11	effects	effect	NNS
cord-270892-ycc3csyh	522	12	measuring	measure	VBG
cord-270892-ycc3csyh	522	13	the	the	DT
cord-270892-ycc3csyh	522	14	inhibition	inhibition	NN
cord-270892-ycc3csyh	522	15	of	of	IN
cord-270892-ycc3csyh	522	16	in	in	FW
cord-270892-ycc3csyh	522	17	vitro	vitro	FW
cord-270892-ycc3csyh	522	18	Cu(II)-catalyzed	cu(ii)-catalyze	VBN
cord-270892-ycc3csyh	522	19	oxidation	oxidation	NN
cord-270892-ycc3csyh	522	20	of	of	IN
cord-270892-ycc3csyh	522	21	human	human	JJ
cord-270892-ycc3csyh	522	22	low	low	JJ
cord-270892-ycc3csyh	522	23	-	-	HYPH
cord-270892-ycc3csyh	522	24	density	density	NN
cord-270892-ycc3csyh	522	25	lipoprotein	lipoprotein	NN
cord-270892-ycc3csyh	522	26	.	.	.
cord-270892-ycc3csyh	523	1	Thereby	thereby	RB
cord-270892-ycc3csyh	523	2	,	,	,
cord-270892-ycc3csyh	523	3	the	the	DT
cord-270892-ycc3csyh	523	4	major	major	JJ
cord-270892-ycc3csyh	523	5	caffeic	caffeic	NN
cord-270892-ycc3csyh	523	6	acid	acid	NN
cord-270892-ycc3csyh	523	7	derivatives	derivative	NNS
cord-270892-ycc3csyh	523	8	,	,	,
cord-270892-ycc3csyh	523	9	cichoric	cichoric	JJ
cord-270892-ycc3csyh	523	10	acid	acid	NN
cord-270892-ycc3csyh	523	11	and	and	CC
cord-270892-ycc3csyh	523	12	echinacoside	echinacoside	NN
cord-270892-ycc3csyh	523	13	,	,	,
cord-270892-ycc3csyh	523	14	showed	show	VBD
cord-270892-ycc3csyh	523	15	the	the	DT
cord-270892-ycc3csyh	523	16	highest	high	JJS
cord-270892-ycc3csyh	523	17	anti	anti	JJ
cord-270892-ycc3csyh	523	18	-	-	JJ
cord-270892-ycc3csyh	523	19	oxidative	oxidative	JJ
cord-270892-ycc3csyh	523	20	effects	effect	NNS
cord-270892-ycc3csyh	523	21	,	,	,
cord-270892-ycc3csyh	523	22	which	which	WDT
cord-270892-ycc3csyh	523	23	was	be	VBD
cord-270892-ycc3csyh	523	24	even	even	RB
cord-270892-ycc3csyh	523	25	higher	high	JJR
cord-270892-ycc3csyh	523	26	when	when	WRB
cord-270892-ycc3csyh	523	27	combined	combine	VBN
cord-270892-ycc3csyh	523	28	with	with	IN
cord-270892-ycc3csyh	523	29	a	a	DT
cord-270892-ycc3csyh	523	30	natural	natural	JJ
cord-270892-ycc3csyh	523	31	mixture	mixture	NN
cord-270892-ycc3csyh	523	32	of	of	IN
cord-270892-ycc3csyh	523	33	alkamides	alkamide	NNS
cord-270892-ycc3csyh	523	34	.	.	.
cord-270892-ycc3csyh	524	1	285	285	CD
cord-270892-ycc3csyh	524	2	Sharma	Sharma	NNP
cord-270892-ycc3csyh	524	3	et	et	NNP
cord-270892-ycc3csyh	524	4	al	al	NNP
cord-270892-ycc3csyh	524	5	.	.	.
cord-270892-ycc3csyh	525	1	used	use	VBN
cord-270892-ycc3csyh	525	2	cytokine	cytokine	JJ
cord-270892-ycc3csyh	525	3	antibody	antibody	NN
cord-270892-ycc3csyh	525	4	arrays	array	NNS
cord-270892-ycc3csyh	525	5	to	to	TO
cord-270892-ycc3csyh	525	6	investigate	investigate	VB
cord-270892-ycc3csyh	525	7	the	the	DT
cord-270892-ycc3csyh	525	8	changes	change	NNS
cord-270892-ycc3csyh	525	9	in	in	IN
cord-270892-ycc3csyh	525	10	the	the	DT
cord-270892-ycc3csyh	525	11	pro	pro	JJ
cord-270892-ycc3csyh	525	12	-	-	JJ
cord-270892-ycc3csyh	525	13	inflammatory	inflammatory	JJ
cord-270892-ycc3csyh	525	14	cytokines	cytokine	NNS
cord-270892-ycc3csyh	525	15	and	and	CC
cord-270892-ycc3csyh	525	16	chemokines	chemokine	NNS
cord-270892-ycc3csyh	525	17	released	release	VBN
cord-270892-ycc3csyh	525	18	from	from	IN
cord-270892-ycc3csyh	525	19	human	human	JJ
cord-270892-ycc3csyh	525	20	bronchial	bronchial	JJ
cord-270892-ycc3csyh	525	21	epithelial	epithelial	JJ
cord-270892-ycc3csyh	525	22	cells	cell	NNS
cord-270892-ycc3csyh	525	23	exposed	expose	VBN
cord-270892-ycc3csyh	525	24	to	to	IN
cord-270892-ycc3csyh	525	25	HRV	HRV	NNP
cord-270892-ycc3csyh	525	26	14	14	CD
cord-270892-ycc3csyh	525	27	.	.	.
cord-270892-ycc3csyh	526	1	286	286	CD
cord-270892-ycc3csyh	526	2	Application	Application	NNP
cord-270892-ycc3csyh	526	3	of	of	IN
cord-270892-ycc3csyh	526	4	two	two	CD
cord-270892-ycc3csyh	526	5	chemically	chemically	RB
cord-270892-ycc3csyh	526	6	characterized	characterize	VBN
cord-270892-ycc3csyh	526	7	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	526	8	extracts	extract	NNS
cord-270892-ycc3csyh	526	9	showed	show	VBD
cord-270892-ycc3csyh	526	10	a	a	DT
cord-270892-ycc3csyh	526	11	reversion	reversion	NN
cord-270892-ycc3csyh	526	12	of	of	IN
cord-270892-ycc3csyh	526	13	the	the	DT
cord-270892-ycc3csyh	526	14	stimulated	stimulated	JJ
cord-270892-ycc3csyh	526	15	release	release	NN
cord-270892-ycc3csyh	526	16	of	of	IN
cord-270892-ycc3csyh	526	17	numerous	numerous	JJ
cord-270892-ycc3csyh	526	18	pro	pro	JJ
cord-270892-ycc3csyh	526	19	-	-	JJ
cord-270892-ycc3csyh	526	20	inflammatory	inflammatory	JJ
cord-270892-ycc3csyh	526	21	cytokine	cytokine	NN
cord-270892-ycc3csyh	526	22	-	-	HYPH
cord-270892-ycc3csyh	526	23	related	relate	VBN
cord-270892-ycc3csyh	526	24	molecules	molecule	NNS
cord-270892-ycc3csyh	526	25	,	,	,
cord-270892-ycc3csyh	526	26	e.g.	e.g.	RB
cord-270892-ycc3csyh	526	27	for	for	IN
cord-270892-ycc3csyh	526	28	the	the	DT
cord-270892-ycc3csyh	526	29	cytokine	cytokine	NN
cord-270892-ycc3csyh	526	30	IL-6	IL-6	NNP
cord-270892-ycc3csyh	526	31	,	,	,
cord-270892-ycc3csyh	526	32	and	and	CC
cord-270892-ycc3csyh	526	33	the	the	DT
cord-270892-ycc3csyh	526	34	chemokines	chemokine	NNS
cord-270892-ycc3csyh	526	35	IL-8	il-8	NN
cord-270892-ycc3csyh	526	36	and	and	CC
cord-270892-ycc3csyh	526	37	eotaxin	eotaxin	NNP
cord-270892-ycc3csyh	526	38	.	.	.
cord-270892-ycc3csyh	527	1	In	in	IN
cord-270892-ycc3csyh	527	2	a	a	DT
cord-270892-ycc3csyh	527	3	similar	similar	JJ
cord-270892-ycc3csyh	527	4	study	study	NN
cord-270892-ycc3csyh	527	5	,	,	,
cord-270892-ycc3csyh	527	6	an	an	DT
cord-270892-ycc3csyh	527	7	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	527	8	extract	extract	NN
cord-270892-ycc3csyh	527	9	rich	rich	JJ
cord-270892-ycc3csyh	527	10	in	in	IN
cord-270892-ycc3csyh	527	11	polysaccharides	polysaccharide	NNS
cord-270892-ycc3csyh	527	12	and	and	CC
cord-270892-ycc3csyh	527	13	another	another	DT
cord-270892-ycc3csyh	527	14	rich	rich	JJ
cord-270892-ycc3csyh	527	15	in	in	IN
cord-270892-ycc3csyh	527	16	alkamides	alkamide	NNS
cord-270892-ycc3csyh	527	17	and	and	CC
cord-270892-ycc3csyh	527	18	caffeic	caffeic	NN
cord-270892-ycc3csyh	527	19	acid	acid	NN
cord-270892-ycc3csyh	527	20	derivatives	derivative	NNS
cord-270892-ycc3csyh	527	21	were	be	VBD
cord-270892-ycc3csyh	527	22	as	as	RB
cord-270892-ycc3csyh	527	23	well	well	RB
cord-270892-ycc3csyh	527	24	able	able	JJ
cord-270892-ycc3csyh	527	25	to	to	TO
cord-270892-ycc3csyh	527	26	neutralize	neutralize	VB
cord-270892-ycc3csyh	527	27	the	the	DT
cord-270892-ycc3csyh	527	28	effects	effect	NNS
cord-270892-ycc3csyh	527	29	of	of	IN
cord-270892-ycc3csyh	527	30	HRV	HRV	NNP
cord-270892-ycc3csyh	527	31	-	-	HYPH
cord-270892-ycc3csyh	527	32	infected	infect	VBN
cord-270892-ycc3csyh	527	33	epithelial	epithelial	JJ
cord-270892-ycc3csyh	527	34	cells	cell	NNS
cord-270892-ycc3csyh	527	35	.	.	.
cord-270892-ycc3csyh	528	1	287	287	CD
cord-270892-ycc3csyh	529	1	Using	use	VBG
cord-270892-ycc3csyh	529	2	gene	gene	NN
cord-270892-ycc3csyh	529	3	expression	expression	NN
cord-270892-ycc3csyh	529	4	analysis	analysis	NN
cord-270892-ycc3csyh	529	5	both	both	DT
cord-270892-ycc3csyh	529	6	studies	study	NNS
cord-270892-ycc3csyh	529	7	revealed	reveal	VBD
cord-270892-ycc3csyh	529	8	the	the	DT
cord-270892-ycc3csyh	529	9	anti	anti	JJ
cord-270892-ycc3csyh	529	10	-	-	JJ
cord-270892-ycc3csyh	529	11	HRV	HRV	NNP
cord-270892-ycc3csyh	529	12	benefit	benefit	NN
cord-270892-ycc3csyh	529	13	of	of	IN
cord-270892-ycc3csyh	529	14	Echinacea	echinacea	NN
cord-270892-ycc3csyh	529	15	preparations	preparation	NNS
cord-270892-ycc3csyh	529	16	being	be	VBG
cord-270892-ycc3csyh	529	17	involved	involve	VBN
cord-270892-ycc3csyh	529	18	in	in	IN
cord-270892-ycc3csyh	529	19	multiple	multiple	JJ
cord-270892-ycc3csyh	529	20	immune	immune	JJ
cord-270892-ycc3csyh	529	21	response	response	NN
cord-270892-ycc3csyh	529	22	signaling	signal	VBG
cord-270892-ycc3csyh	529	23	pathways	pathway	NNS
cord-270892-ycc3csyh	529	24	.	.	.
cord-270892-ycc3csyh	530	1	Taken	take	VBN
cord-270892-ycc3csyh	530	2	together	together	RB
cord-270892-ycc3csyh	530	3	,	,	,
cord-270892-ycc3csyh	530	4	the	the	DT
cord-270892-ycc3csyh	530	5	numerous	numerous	JJ
cord-270892-ycc3csyh	530	6	pharmacological	pharmacological	JJ
cord-270892-ycc3csyh	530	7	findings	finding	NNS
cord-270892-ycc3csyh	530	8	from	from	IN
cord-270892-ycc3csyh	530	9	literature	literature	NN
cord-270892-ycc3csyh	530	10	,	,	,
cord-270892-ycc3csyh	530	11	the	the	DT
cord-270892-ycc3csyh	530	12	potential	potential	NN
cord-270892-ycc3csyh	530	13	of	of	IN
cord-270892-ycc3csyh	530	14	Echinacea	echinacea	JJ
cord-270892-ycc3csyh	530	15	preparations	preparation	NNS
cord-270892-ycc3csyh	530	16	,	,	,
cord-270892-ycc3csyh	530	17	and	and	CC
cord-270892-ycc3csyh	530	18	their	-PRON-	PRP$
cord-270892-ycc3csyh	530	19	constituents	constituent	NNS
cord-270892-ycc3csyh	530	20	to	to	TO
cord-270892-ycc3csyh	530	21	combat	combat	VB
cord-270892-ycc3csyh	530	22	or	or	CC
cord-270892-ycc3csyh	530	23	prevent	prevent	VB
cord-270892-ycc3csyh	530	24	common	common	JJ
cord-270892-ycc3csyh	530	25	cold	cold	NN
cord-270892-ycc3csyh	530	26	can	can	MD
cord-270892-ycc3csyh	530	27	be	be	VB
cord-270892-ycc3csyh	530	28	deduced	deduce	VBN
cord-270892-ycc3csyh	530	29	to	to	TO
cord-270892-ycc3csyh	530	30	immune	immune	VB
cord-270892-ycc3csyh	530	31	modulating	modulating	NN
cord-270892-ycc3csyh	530	32	,	,	,
cord-270892-ycc3csyh	530	33	anti	anti	JJ
cord-270892-ycc3csyh	530	34	-	-	JJ
cord-270892-ycc3csyh	530	35	inflammatory	inflammatory	JJ
cord-270892-ycc3csyh	530	36	,	,	,
cord-270892-ycc3csyh	530	37	and	and	CC
cord-270892-ycc3csyh	530	38	anti	anti	JJ
cord-270892-ycc3csyh	530	39	-	-	JJ
cord-270892-ycc3csyh	530	40	oxidative	oxidative	JJ
cord-270892-ycc3csyh	530	41	properties	property	NNS
cord-270892-ycc3csyh	530	42	that	that	WDT
cord-270892-ycc3csyh	530	43	may	may	MD
cord-270892-ycc3csyh	530	44	also	also	RB
cord-270892-ycc3csyh	530	45	act	act	VB
cord-270892-ycc3csyh	530	46	in	in	IN
cord-270892-ycc3csyh	530	47	some	some	DT
cord-270892-ycc3csyh	530	48	combination	combination	NN
cord-270892-ycc3csyh	530	49	of	of	IN
cord-270892-ycc3csyh	530	50	these	these	DT
cord-270892-ycc3csyh	530	51	event	event	NN
cord-270892-ycc3csyh	530	52	,	,	,
cord-270892-ycc3csyh	530	53	rather	rather	RB
cord-270892-ycc3csyh	530	54	than	than	IN
cord-270892-ycc3csyh	530	55	acting	act	VBG
cord-270892-ycc3csyh	530	56	directly	directly	RB
cord-270892-ycc3csyh	530	57	on	on	IN
cord-270892-ycc3csyh	530	58	HRV	HRV	NNP
cord-270892-ycc3csyh	530	59	.	.	.
cord-270892-ycc3csyh	531	1	Garlic	garlic	NN
cord-270892-ycc3csyh	531	2	cloves	clove	NNS
cord-270892-ycc3csyh	531	3	have	have	VBP
cord-270892-ycc3csyh	531	4	been	be	VBN
cord-270892-ycc3csyh	531	5	used	use	VBN
cord-270892-ycc3csyh	531	6	traditionally	traditionally	RB
cord-270892-ycc3csyh	531	7	to	to	TO
cord-270892-ycc3csyh	531	8	treat	treat	VB
cord-270892-ycc3csyh	531	9	a	a	DT
cord-270892-ycc3csyh	531	10	number	number	NN
cord-270892-ycc3csyh	531	11	of	of	IN
cord-270892-ycc3csyh	531	12	infectious	infectious	JJ
cord-270892-ycc3csyh	531	13	diseases	disease	NNS
cord-270892-ycc3csyh	531	14	.	.	.
cord-270892-ycc3csyh	532	1	However	however	RB
cord-270892-ycc3csyh	532	2	,	,	,
cord-270892-ycc3csyh	532	3	only	only	RB
cord-270892-ycc3csyh	532	4	few	few	JJ
cord-270892-ycc3csyh	532	5	confirmatory	confirmatory	JJ
cord-270892-ycc3csyh	532	6	studies	study	NNS
cord-270892-ycc3csyh	532	7	have	have	VBP
cord-270892-ycc3csyh	532	8	been	be	VBN
cord-270892-ycc3csyh	532	9	published	publish	VBN
cord-270892-ycc3csyh	532	10	regarding	regard	VBG
cord-270892-ycc3csyh	532	11	the	the	DT
cord-270892-ycc3csyh	532	12	traditional	traditional	JJ
cord-270892-ycc3csyh	532	13	antiviral	antiviral	JJ
cord-270892-ycc3csyh	532	14	uses	use	NNS
cord-270892-ycc3csyh	532	15	.	.	.
cord-270892-ycc3csyh	533	1	The	the	DT
cord-270892-ycc3csyh	533	2	clinical	clinical	JJ
cord-270892-ycc3csyh	533	3	effectiveness	effectiveness	NN
cord-270892-ycc3csyh	533	4	of	of	IN
cord-270892-ycc3csyh	533	5	garlic	garlic	NN
cord-270892-ycc3csyh	533	6	on	on	IN
cord-270892-ycc3csyh	533	7	the	the	DT
cord-270892-ycc3csyh	533	8	prevention	prevention	NN
cord-270892-ycc3csyh	533	9	of	of	IN
cord-270892-ycc3csyh	533	10	common	common	JJ
cord-270892-ycc3csyh	533	11	cold	cold	NN
cord-270892-ycc3csyh	533	12	was	be	VBD
cord-270892-ycc3csyh	533	13	investigated	investigate	VBN
cord-270892-ycc3csyh	533	14	by	by	IN
cord-270892-ycc3csyh	533	15	Josling	Josling	NNP
cord-270892-ycc3csyh	533	16	in	in	IN
cord-270892-ycc3csyh	533	17	2005	2005	CD
cord-270892-ycc3csyh	533	18	,	,	,
cord-270892-ycc3csyh	533	19	who	who	WP
cord-270892-ycc3csyh	533	20	published	publish	VBD
cord-270892-ycc3csyh	533	21	a	a	DT
cord-270892-ycc3csyh	533	22	double	double	JJ
cord-270892-ycc3csyh	533	23	-	-	HYPH
cord-270892-ycc3csyh	533	24	blind	blind	JJ
cord-270892-ycc3csyh	533	25	,	,	,
cord-270892-ycc3csyh	533	26	placebo	placebo	NN
cord-270892-ycc3csyh	533	27	controlled	control	VBN
cord-270892-ycc3csyh	533	28	study	study	NN
cord-270892-ycc3csyh	533	29	assessing	assess	VBG
cord-270892-ycc3csyh	533	30	146	146	CD
cord-270892-ycc3csyh	533	31	patients	patient	NNS
cord-270892-ycc3csyh	533	32	more	more	JJR
cord-270892-ycc3csyh	533	33	than	than	IN
cord-270892-ycc3csyh	533	34	a	a	DT
cord-270892-ycc3csyh	533	35	12-week	12-week	JJ
cord-270892-ycc3csyh	533	36	treatment	treatment	NN
cord-270892-ycc3csyh	533	37	period	period	NN
cord-270892-ycc3csyh	533	38	with	with	IN
cord-270892-ycc3csyh	533	39	an	an	DT
cord-270892-ycc3csyh	533	40	allicin	allicin	NN
cord-270892-ycc3csyh	533	41	-	-	HYPH
cord-270892-ycc3csyh	533	42	containing	contain	VBG
cord-270892-ycc3csyh	533	43	garlic	garlic	NN
cord-270892-ycc3csyh	533	44	supplement	supplement	NN
cord-270892-ycc3csyh	533	45	.	.	.
cord-270892-ycc3csyh	534	1	288	288	CD
cord-270892-ycc3csyh	534	2	Common	common	JJ
cord-270892-ycc3csyh	534	3	cold	cold	JJ
cord-270892-ycc3csyh	534	4	infections	infection	NNS
cord-270892-ycc3csyh	534	5	and	and	CC
cord-270892-ycc3csyh	534	6	symptoms	symptom	NNS
cord-270892-ycc3csyh	534	7	were	be	VBD
cord-270892-ycc3csyh	534	8	recorded	record	VBN
cord-270892-ycc3csyh	534	9	in	in	IN
cord-270892-ycc3csyh	534	10	a	a	DT
cord-270892-ycc3csyh	534	11	daily	daily	JJ
cord-270892-ycc3csyh	534	12	diary	diary	NN
cord-270892-ycc3csyh	534	13	.	.	.
cord-270892-ycc3csyh	535	1	Patients	patient	NNS
cord-270892-ycc3csyh	535	2	in	in	IN
cord-270892-ycc3csyh	535	3	the	the	DT
cord-270892-ycc3csyh	535	4	treatment	treatment	NN
cord-270892-ycc3csyh	535	5	group	group	NN
cord-270892-ycc3csyh	535	6	had	have	VBD
cord-270892-ycc3csyh	535	7	significantly	significantly	RB
cord-270892-ycc3csyh	535	8	fewer	few	JJR
cord-270892-ycc3csyh	535	9	colds	cold	NNS
cord-270892-ycc3csyh	535	10	than	than	IN
cord-270892-ycc3csyh	535	11	patients	patient	NNS
cord-270892-ycc3csyh	535	12	in	in	IN
cord-270892-ycc3csyh	535	13	the	the	DT
cord-270892-ycc3csyh	535	14	placebo	placebo	NN
cord-270892-ycc3csyh	535	15	group	group	NN
cord-270892-ycc3csyh	535	16	(	(	-LRB-
cord-270892-ycc3csyh	535	17	24	24	CD
cord-270892-ycc3csyh	535	18	vs.	vs.	CC
cord-270892-ycc3csyh	535	19	65	65	CD
cord-270892-ycc3csyh	535	20	,	,	,
cord-270892-ycc3csyh	535	21	Po0.001	Po0.001	NNP
cord-270892-ycc3csyh	535	22	)	)	-RRB-
cord-270892-ycc3csyh	535	23	who	who	WP
cord-270892-ycc3csyh	535	24	also	also	RB
cord-270892-ycc3csyh	535	25	had	have	VBD
cord-270892-ycc3csyh	535	26	a	a	DT
cord-270892-ycc3csyh	535	27	longer	long	JJR
cord-270892-ycc3csyh	535	28	duration	duration	NN
cord-270892-ycc3csyh	535	29	of	of	IN
cord-270892-ycc3csyh	535	30	symptoms	symptom	NNS
cord-270892-ycc3csyh	535	31	(	(	-LRB-
cord-270892-ycc3csyh	535	32	5.01	5.01	CD
cord-270892-ycc3csyh	535	33	vs.	vs.	IN
cord-270892-ycc3csyh	535	34	1.52	1.52	CD
cord-270892-ycc3csyh	535	35	days	day	NNS
cord-270892-ycc3csyh	535	36	,	,	,
cord-270892-ycc3csyh	535	37	Po0.001	Po0.001	NNP
cord-270892-ycc3csyh	535	38	)	)	-RRB-
cord-270892-ycc3csyh	535	39	.	.	.
cord-270892-ycc3csyh	536	1	As	as	RB
cord-270892-ycc3csyh	536	2	soon	soon	RB
cord-270892-ycc3csyh	536	3	as	as	IN
cord-270892-ycc3csyh	536	4	the	the	DT
cord-270892-ycc3csyh	536	5	garlic	garlic	NN
cord-270892-ycc3csyh	536	6	is	be	VBZ
cord-270892-ycc3csyh	536	7	chewed	chew	VBN
cord-270892-ycc3csyh	536	8	,	,	,
cord-270892-ycc3csyh	536	9	cut	cut	VBN
cord-270892-ycc3csyh	536	10	,	,	,
cord-270892-ycc3csyh	536	11	or	or	CC
cord-270892-ycc3csyh	536	12	pressed	press	VBD
cord-270892-ycc3csyh	536	13	,	,	,
cord-270892-ycc3csyh	536	14	its	-PRON-	PRP$
cord-270892-ycc3csyh	536	15	main	main	JJ
cord-270892-ycc3csyh	536	16	ingredient	ingredient	NN
cord-270892-ycc3csyh	536	17	,	,	,
cord-270892-ycc3csyh	536	18	the	the	DT
cord-270892-ycc3csyh	536	19	sulphur	sulphur	NN
cord-270892-ycc3csyh	536	20	containing	contain	VBG
cord-270892-ycc3csyh	536	21	alliin	alliin	NNP
cord-270892-ycc3csyh	536	22	,	,	,
cord-270892-ycc3csyh	536	23	is	be	VBZ
cord-270892-ycc3csyh	536	24	broken	break	VBN
cord-270892-ycc3csyh	536	25	down	down	RP
cord-270892-ycc3csyh	536	26	by	by	IN
cord-270892-ycc3csyh	536	27	the	the	DT
cord-270892-ycc3csyh	536	28	enzyme	enzyme	NN
cord-270892-ycc3csyh	536	29	alliinase	alliinase	NN
cord-270892-ycc3csyh	536	30	to	to	IN
cord-270892-ycc3csyh	536	31	the	the	DT
cord-270892-ycc3csyh	536	32	thiosulfinate	thiosulfinate	NNP
cord-270892-ycc3csyh	536	33	allicin	allicin	NNP
cord-270892-ycc3csyh	536	34	.	.	.
cord-270892-ycc3csyh	537	1	By	by	IN
cord-270892-ycc3csyh	537	2	steam	steam	NN
cord-270892-ycc3csyh	537	3	distillation	distillation	NN
cord-270892-ycc3csyh	537	4	allicin	allicin	NN
cord-270892-ycc3csyh	537	5	is	be	VBZ
cord-270892-ycc3csyh	537	6	transformed	transform	VBN
cord-270892-ycc3csyh	537	7	to	to	IN
cord-270892-ycc3csyh	537	8	diallyl	diallyl	JJ
cord-270892-ycc3csyh	537	9	disulfide	disulfide	NN
cord-270892-ycc3csyh	537	10	and	and	CC
cord-270892-ycc3csyh	537	11	diallyl	diallyl	NNP
cord-270892-ycc3csyh	537	12	trisulfide	trisulfide	NNP
cord-270892-ycc3csyh	538	1	that	that	WDT
cord-270892-ycc3csyh	538	2	are	be	VBP
cord-270892-ycc3csyh	538	3	responsible	responsible	JJ
cord-270892-ycc3csyh	538	4	for	for	IN
cord-270892-ycc3csyh	538	5	the	the	DT
cord-270892-ycc3csyh	538	6	distinctive	distinctive	JJ
cord-270892-ycc3csyh	538	7	smell	smell	NN
cord-270892-ycc3csyh	538	8	of	of	IN
cord-270892-ycc3csyh	538	9	garlic	garlic	NN
cord-270892-ycc3csyh	538	10	.	.	.
cord-270892-ycc3csyh	539	1	Further	further	RB
cord-270892-ycc3csyh	539	2	,	,	,
cord-270892-ycc3csyh	539	3	allicin	allicin	NN
cord-270892-ycc3csyh	539	4	transformation	transformation	NN
cord-270892-ycc3csyh	539	5	compounds	compound	NNS
cord-270892-ycc3csyh	539	6	,	,	,
cord-270892-ycc3csyh	539	7	such	such	JJ
cord-270892-ycc3csyh	539	8	as	as	IN
cord-270892-ycc3csyh	539	9	E	e	NN
cord-270892-ycc3csyh	539	10	-	-	:
cord-270892-ycc3csyh	539	11	and	and	CC
cord-270892-ycc3csyh	539	12	Z	Z	NNP
cord-270892-ycc3csyh	539	13	-	-	HYPH
cord-270892-ycc3csyh	539	14	ajoene	ajoene	NNP
cord-270892-ycc3csyh	539	15	,	,	,
cord-270892-ycc3csyh	539	16	are	be	VBP
cord-270892-ycc3csyh	539	17	not	not	RB
cord-270892-ycc3csyh	539	18	found	find	VBN
cord-270892-ycc3csyh	539	19	in	in	IN
cord-270892-ycc3csyh	539	20	fresh	fresh	JJ
cord-270892-ycc3csyh	539	21	garlic	garlic	NN
cord-270892-ycc3csyh	539	22	,	,	,
cord-270892-ycc3csyh	539	23	but	but	CC
cord-270892-ycc3csyh	539	24	in	in	IN
cord-270892-ycc3csyh	539	25	lipophilic	lipophilic	JJ
cord-270892-ycc3csyh	539	26	extracts	extract	NNS
cord-270892-ycc3csyh	539	27	.	.	.
cord-270892-ycc3csyh	540	1	By	by	IN
cord-270892-ycc3csyh	540	2	investigation	investigation	NN
cord-270892-ycc3csyh	540	3	of	of	IN
cord-270892-ycc3csyh	540	4	different	different	JJ
cord-270892-ycc3csyh	540	5	garlic	garlic	NN
cord-270892-ycc3csyh	540	6	extracts	extract	NNS
cord-270892-ycc3csyh	540	7	and	and	CC
cord-270892-ycc3csyh	540	8	isolates	isolate	NNS
cord-270892-ycc3csyh	540	9	against	against	IN
cord-270892-ycc3csyh	540	10	a	a	DT
cord-270892-ycc3csyh	540	11	number	number	NN
cord-270892-ycc3csyh	540	12	of	of	IN
cord-270892-ycc3csyh	540	13	different	different	JJ
cord-270892-ycc3csyh	540	14	human	human	JJ
cord-270892-ycc3csyh	540	15	pathological	pathological	JJ
cord-270892-ycc3csyh	540	16	viruses	virus	NNS
cord-270892-ycc3csyh	540	17	,	,	,
cord-270892-ycc3csyh	540	18	Weber	Weber	NNP
cord-270892-ycc3csyh	540	19	et	et	NNP
cord-270892-ycc3csyh	540	20	al	al	NNP
cord-270892-ycc3csyh	540	21	.	.	NNP
cord-270892-ycc3csyh	540	22	could	could	MD
cord-270892-ycc3csyh	540	23	show	show	VB
cord-270892-ycc3csyh	540	24	that	that	IN
cord-270892-ycc3csyh	540	25	allicin	allicin	NN
cord-270892-ycc3csyh	540	26	was	be	VBD
cord-270892-ycc3csyh	540	27	the	the	DT
cord-270892-ycc3csyh	540	28	most	most	RBS
cord-270892-ycc3csyh	540	29	active	active	JJ
cord-270892-ycc3csyh	540	30	virucidal	virucidal	JJ
cord-270892-ycc3csyh	540	31	component	component	NN
cord-270892-ycc3csyh	540	32	from	from	IN
cord-270892-ycc3csyh	540	33	fresh	fresh	JJ
cord-270892-ycc3csyh	540	34	garlic	garlic	NN
cord-270892-ycc3csyh	540	35	and	and	CC
cord-270892-ycc3csyh	540	36	fresh	fresh	JJ
cord-270892-ycc3csyh	540	37	extracts	extract	NNS
cord-270892-ycc3csyh	540	38	.	.	.
cord-270892-ycc3csyh	541	1	289	289	CD
cord-270892-ycc3csyh	541	2	Results	result	NNS
cord-270892-ycc3csyh	541	3	of	of	IN
cord-270892-ycc3csyh	541	4	the	the	DT
cord-270892-ycc3csyh	541	5	direct	direct	JJ
cord-270892-ycc3csyh	541	6	pre	pre	JJ
cord-270892-ycc3csyh	541	7	-	-	JJ
cord-270892-ycc3csyh	541	8	HRV-2-infection	hrv-2-infection	JJ
cord-270892-ycc3csyh	541	9	incubation	incubation	NN
cord-270892-ycc3csyh	541	10	assay	assay	NN
cord-270892-ycc3csyh	541	11	let	let	VB
cord-270892-ycc3csyh	541	12	suggest	suggest	VB
cord-270892-ycc3csyh	541	13	allicin	allicin	JJ
cord-270892-ycc3csyh	541	14	to	to	TO
cord-270892-ycc3csyh	541	15	bind	bind	VB
cord-270892-ycc3csyh	541	16	to	to	IN
cord-270892-ycc3csyh	541	17	the	the	DT
cord-270892-ycc3csyh	541	18	viral	viral	JJ
cord-270892-ycc3csyh	541	19	protein	protein	NN
cord-270892-ycc3csyh	541	20	capsid	capsid	NN
cord-270892-ycc3csyh	541	21	,	,	,
cord-270892-ycc3csyh	541	22	leading	lead	VBG
cord-270892-ycc3csyh	541	23	to	to	IN
cord-270892-ycc3csyh	541	24	a	a	DT
cord-270892-ycc3csyh	541	25	subsequent	subsequent	JJ
cord-270892-ycc3csyh	541	26	inhibition	inhibition	NN
cord-270892-ycc3csyh	541	27	of	of	IN
cord-270892-ycc3csyh	541	28	viral	viral	JJ
cord-270892-ycc3csyh	541	29	adsorption	adsorption	NN
cord-270892-ycc3csyh	541	30	and	and	CC
cord-270892-ycc3csyh	541	31	penetration	penetration	NN
cord-270892-ycc3csyh	541	32	.	.	.
cord-270892-ycc3csyh	542	1	Although	although	IN
cord-270892-ycc3csyh	542	2	the	the	DT
cord-270892-ycc3csyh	542	3	garlic	garlic	NN
cord-270892-ycc3csyh	542	4	thiosulfinates	thiosulfinate	NNS
cord-270892-ycc3csyh	542	5	are	be	VBP
cord-270892-ycc3csyh	542	6	endowed	endow	VBN
cord-270892-ycc3csyh	542	7	with	with	IN
cord-270892-ycc3csyh	542	8	significant	significant	JJ
cord-270892-ycc3csyh	542	9	cytotoxicity	cytotoxicity	NN
cord-270892-ycc3csyh	542	10	,	,	,
cord-270892-ycc3csyh	542	11	the	the	DT
cord-270892-ycc3csyh	542	12	antiviral	antiviral	JJ
cord-270892-ycc3csyh	542	13	effects	effect	NNS
cord-270892-ycc3csyh	542	14	were	be	VBD
cord-270892-ycc3csyh	542	15	obtained	obtain	VBN
cord-270892-ycc3csyh	542	16	in	in	IN
cord-270892-ycc3csyh	542	17	nontoxic	nontoxic	JJ
cord-270892-ycc3csyh	542	18	concentrations	concentration	NNS
cord-270892-ycc3csyh	542	19	.	.	.
cord-270892-ycc3csyh	543	1	289	289	CD
cord-270892-ycc3csyh	544	1	Beside	beside	IN
cord-270892-ycc3csyh	544	2	the	the	DT
cord-270892-ycc3csyh	544	3	direct	direct	JJ
cord-270892-ycc3csyh	544	4	anti	anti	JJ
cord-270892-ycc3csyh	544	5	-	-	JJ
cord-270892-ycc3csyh	544	6	HRV	HRV	NNP
cord-270892-ycc3csyh	544	7	effect	effect	NN
cord-270892-ycc3csyh	544	8	of	of	IN
cord-270892-ycc3csyh	544	9	fresh	fresh	JJ
cord-270892-ycc3csyh	544	10	garlic	garlic	NN
cord-270892-ycc3csyh	544	11	extract	extract	NN
cord-270892-ycc3csyh	544	12	and	and	CC
cord-270892-ycc3csyh	544	13	allicin	allicin	NN
cord-270892-ycc3csyh	544	14	,	,	,
cord-270892-ycc3csyh	544	15	a	a	DT
cord-270892-ycc3csyh	544	16	number	number	NN
cord-270892-ycc3csyh	544	17	of	of	IN
cord-270892-ycc3csyh	544	18	human	human	JJ
cord-270892-ycc3csyh	544	19	immune	immune	JJ
cord-270892-ycc3csyh	544	20	functions	function	NNS
cord-270892-ycc3csyh	544	21	were	be	VBD
cord-270892-ycc3csyh	544	22	found	find	VBN
cord-270892-ycc3csyh	544	23	to	to	TO
cord-270892-ycc3csyh	544	24	be	be	VB
cord-270892-ycc3csyh	544	25	enhanced	enhance	VBN
cord-270892-ycc3csyh	544	26	in	in	IN
cord-270892-ycc3csyh	544	27	vitro	vitro	FW
cord-270892-ycc3csyh	544	28	by	by	IN
cord-270892-ycc3csyh	544	29	aqueous	aqueous	JJ
cord-270892-ycc3csyh	544	30	garlic	garlic	NN
cord-270892-ycc3csyh	544	31	extract	extract	NN
cord-270892-ycc3csyh	544	32	,	,	,
cord-270892-ycc3csyh	544	33	its	-PRON-	PRP$
cord-270892-ycc3csyh	544	34	polar	polar	JJ
cord-270892-ycc3csyh	544	35	,	,	,
cord-270892-ycc3csyh	544	36	and	and	CC
cord-270892-ycc3csyh	544	37	thiosulfinate	thiosulfinate	NN
cord-270892-ycc3csyh	544	38	fractions	fraction	NNS
cord-270892-ycc3csyh	544	39	.	.	.
cord-270892-ycc3csyh	545	1	290	290	CD
cord-270892-ycc3csyh	545	2	 	 	_SP
cord-270892-ycc3csyh	546	1	In	in	IN
cord-270892-ycc3csyh	546	2	North	North	NNP
cord-270892-ycc3csyh	546	3	America	America	NNP
cord-270892-ycc3csyh	546	4	,	,	,
cord-270892-ycc3csyh	546	5	Panax	Panax	NNP
cord-270892-ycc3csyh	546	6	quinquefolium	quinquefolium	NN
cord-270892-ycc3csyh	546	7	,	,	,
cord-270892-ycc3csyh	546	8	the	the	DT
cord-270892-ycc3csyh	546	9	ginseng	ginseng	NN
cord-270892-ycc3csyh	546	10	species	specie	VBZ
cord-270892-ycc3csyh	546	11	indigenous	indigenous	JJ
cord-270892-ycc3csyh	546	12	to	to	IN
cord-270892-ycc3csyh	546	13	both	both	DT
cord-270892-ycc3csyh	546	14	Canada	Canada	NNP
cord-270892-ycc3csyh	546	15	and	and	CC
cord-270892-ycc3csyh	546	16	the	the	DT
cord-270892-ycc3csyh	546	17	United	United	NNP
cord-270892-ycc3csyh	546	18	States	States	NNP
cord-270892-ycc3csyh	546	19	,	,	,
cord-270892-ycc3csyh	546	20	has	have	VBZ
cord-270892-ycc3csyh	546	21	been	be	VBN
cord-270892-ycc3csyh	546	22	a	a	DT
cord-270892-ycc3csyh	546	23	popular	popular	JJ
cord-270892-ycc3csyh	546	24	herbal	herbal	JJ
cord-270892-ycc3csyh	546	25	remedy	remedy	NN
cord-270892-ycc3csyh	546	26	to	to	IN
cord-270892-ycc3csyh	546	27	combat	combat	NN
cord-270892-ycc3csyh	546	28	stress	stress	NN
cord-270892-ycc3csyh	546	29	,	,	,
cord-270892-ycc3csyh	546	30	and	and	CC
cord-270892-ycc3csyh	546	31	to	to	TO
cord-270892-ycc3csyh	546	32	modulate	modulate	VB
cord-270892-ycc3csyh	546	33	both	both	DT
cord-270892-ycc3csyh	546	34	natural	natural	JJ
cord-270892-ycc3csyh	546	35	and	and	CC
cord-270892-ycc3csyh	546	36	acquired	acquire	VBD
cord-270892-ycc3csyh	546	37	immune	immune	JJ
cord-270892-ycc3csyh	546	38	responses	response	NNS
cord-270892-ycc3csyh	546	39	.	.	.
cord-270892-ycc3csyh	547	1	American	american	JJ
cord-270892-ycc3csyh	547	2	ginseng	ginseng	NN
cord-270892-ycc3csyh	547	3	root	root	NN
cord-270892-ycc3csyh	547	4	extracts	extract	NNS
cord-270892-ycc3csyh	547	5	,	,	,
cord-270892-ycc3csyh	547	6	rich	rich	JJ
cord-270892-ycc3csyh	547	7	in	in	IN
cord-270892-ycc3csyh	547	8	poly	poly	JJ
cord-270892-ycc3csyh	547	9	-	-	HYPH
cord-270892-ycc3csyh	547	10	furanosyl	furanosyl	JJ
cord-270892-ycc3csyh	547	11	-	-	HYPH
cord-270892-ycc3csyh	547	12	pyranosyl	pyranosyl	NN
cord-270892-ycc3csyh	547	13	-	-	HYPH
cord-270892-ycc3csyh	547	14	saccharides	saccharide	NNS
cord-270892-ycc3csyh	547	15	,	,	,
cord-270892-ycc3csyh	547	16	have	have	VBP
cord-270892-ycc3csyh	547	17	been	be	VBN
cord-270892-ycc3csyh	547	18	found	find	VBN
cord-270892-ycc3csyh	547	19	efficacious	efficacious	JJ
cord-270892-ycc3csyh	547	20	in	in	IN
cord-270892-ycc3csyh	547	21	the	the	DT
cord-270892-ycc3csyh	547	22	prevention	prevention	NN
cord-270892-ycc3csyh	547	23	of	of	IN
cord-270892-ycc3csyh	547	24	upper	upper	JJ
cord-270892-ycc3csyh	547	25	respiratory	respiratory	JJ
cord-270892-ycc3csyh	547	26	infections	infection	NNS
cord-270892-ycc3csyh	547	27	in	in	IN
cord-270892-ycc3csyh	547	28	immunocompetent	immunocompetent	JJ
cord-270892-ycc3csyh	547	29	healthy	healthy	JJ
cord-270892-ycc3csyh	547	30	adults	adult	NNS
cord-270892-ycc3csyh	547	31	.	.	.
cord-270892-ycc3csyh	548	1	291	291	CD
cord-270892-ycc3csyh	548	2	,	,	,
cord-270892-ycc3csyh	548	3	292	292	CD
cord-270892-ycc3csyh	549	1	In	in	IN
cord-270892-ycc3csyh	549	2	a	a	DT
cord-270892-ycc3csyh	549	3	randomized	randomized	JJ
cord-270892-ycc3csyh	549	4	,	,	,
cord-270892-ycc3csyh	549	5	double	double	JJ
cord-270892-ycc3csyh	549	6	-	-	HYPH
cord-270892-ycc3csyh	549	7	blind	blind	JJ
cord-270892-ycc3csyh	549	8	,	,	,
cord-270892-ycc3csyh	549	9	placebo	placebo	NN
cord-270892-ycc3csyh	549	10	controlled	control	VBN
cord-270892-ycc3csyh	549	11	trial	trial	NN
cord-270892-ycc3csyh	549	12	,	,	,
cord-270892-ycc3csyh	549	13	200	200	CD
cord-270892-ycc3csyh	549	14	mg	mg	CD
cord-270892-ycc3csyh	549	15	of	of	IN
cord-270892-ycc3csyh	549	16	a	a	DT
cord-270892-ycc3csyh	549	17	proprietary	proprietary	JJ
cord-270892-ycc3csyh	549	18	American	american	JJ
cord-270892-ycc3csyh	549	19	ginseng	ginseng	NN
cord-270892-ycc3csyh	549	20	root	root	NN
cord-270892-ycc3csyh	549	21	extract	extract	NN
cord-270892-ycc3csyh	549	22	was	be	VBD
cord-270892-ycc3csyh	549	23	given	give	VBN
cord-270892-ycc3csyh	549	24	to	to	IN
cord-270892-ycc3csyh	549	25	43	43	CD
cord-270892-ycc3csyh	549	26	community	community	NN
cord-270892-ycc3csyh	549	27	-	-	HYPH
cord-270892-ycc3csyh	549	28	dwelling	dwell	VBG
cord-270892-ycc3csyh	549	29	elderly	elderly	JJ
cord-270892-ycc3csyh	549	30	adults	adult	NNS
cord-270892-ycc3csyh	549	31	(	(	-LRB-
cord-270892-ycc3csyh	549	32	age	age	NN
cord-270892-ycc3csyh	549	33	465	465	CD
cord-270892-ycc3csyh	549	34	year	year	NN
cord-270892-ycc3csyh	549	35	)	)	-RRB-
cord-270892-ycc3csyh	549	36	twice	twice	PDT
cord-270892-ycc3csyh	549	37	a	a	DT
cord-270892-ycc3csyh	549	38	day	day	NN
cord-270892-ycc3csyh	549	39	more	more	JJR
cord-270892-ycc3csyh	549	40	than	than	IN
cord-270892-ycc3csyh	549	41	a	a	DT
cord-270892-ycc3csyh	549	42	'	'	``
cord-270892-ycc3csyh	549	43	'	'	``
cord-270892-ycc3csyh	549	44	cold	cold	JJ
cord-270892-ycc3csyh	549	45	and	and	CC
cord-270892-ycc3csyh	549	46	flu	flu	NN
cord-270892-ycc3csyh	549	47	'	'	''
cord-270892-ycc3csyh	549	48	'	'	''
cord-270892-ycc3csyh	549	49	season	season	NN
cord-270892-ycc3csyh	549	50	period	period	NN
cord-270892-ycc3csyh	549	51	of	of	IN
cord-270892-ycc3csyh	549	52	4	4	CD
cord-270892-ycc3csyh	549	53	months	month	NNS
cord-270892-ycc3csyh	549	54	.	.	.
cord-270892-ycc3csyh	550	1	One	one	CD
cord-270892-ycc3csyh	550	2	month	month	NN
cord-270892-ycc3csyh	550	3	into	into	IN
cord-270892-ycc3csyh	550	4	the	the	DT
cord-270892-ycc3csyh	550	5	study	study	NN
cord-270892-ycc3csyh	550	6	,	,	,
cord-270892-ycc3csyh	550	7	all	all	DT
cord-270892-ycc3csyh	550	8	participants	participant	NNS
cord-270892-ycc3csyh	550	9	received	receive	VBD
cord-270892-ycc3csyh	550	10	an	an	DT
cord-270892-ycc3csyh	550	11	influenza	influenza	NN
cord-270892-ycc3csyh	550	12	vaccination	vaccination	NN
cord-270892-ycc3csyh	550	13	.	.	.
cord-270892-ycc3csyh	551	1	During	during	IN
cord-270892-ycc3csyh	551	2	the	the	DT
cord-270892-ycc3csyh	551	3	first	first	JJ
cord-270892-ycc3csyh	551	4	two	two	CD
cord-270892-ycc3csyh	551	5	months	month	NNS
cord-270892-ycc3csyh	551	6	,	,	,
cord-270892-ycc3csyh	551	7	no	no	DT
cord-270892-ycc3csyh	551	8	significant	significant	JJ
cord-270892-ycc3csyh	551	9	differences	difference	NNS
cord-270892-ycc3csyh	551	10	in	in	IN
cord-270892-ycc3csyh	551	11	duration	duration	NN
cord-270892-ycc3csyh	551	12	and	and	CC
cord-270892-ycc3csyh	551	13	incidence	incidence	NN
cord-270892-ycc3csyh	551	14	were	be	VBD
cord-270892-ycc3csyh	551	15	observed	observe	VBN
cord-270892-ycc3csyh	551	16	when	when	WRB
cord-270892-ycc3csyh	551	17	compared	compare	VBN
cord-270892-ycc3csyh	551	18	to	to	IN
cord-270892-ycc3csyh	551	19	placebo	placebo	NN
cord-270892-ycc3csyh	551	20	.	.	.
cord-270892-ycc3csyh	552	1	However	however	RB
cord-270892-ycc3csyh	552	2	,	,	,
cord-270892-ycc3csyh	552	3	during	during	IN
cord-270892-ycc3csyh	552	4	the	the	DT
cord-270892-ycc3csyh	552	5	last	last	JJ
cord-270892-ycc3csyh	552	6	two	two	CD
cord-270892-ycc3csyh	552	7	months	month	NNS
cord-270892-ycc3csyh	552	8	significantly	significantly	RB
cord-270892-ycc3csyh	552	9	fewer	few	JJR
cord-270892-ycc3csyh	552	10	subjects	subject	NNS
cord-270892-ycc3csyh	552	11	of	of	IN
cord-270892-ycc3csyh	552	12	the	the	DT
cord-270892-ycc3csyh	552	13	ginseng	ginseng	NN
cord-270892-ycc3csyh	552	14	group	group	NN
cord-270892-ycc3csyh	552	15	reported	report	VBD
cord-270892-ycc3csyh	552	16	acute	acute	JJ
cord-270892-ycc3csyh	552	17	respiratory	respiratory	JJ
cord-270892-ycc3csyh	552	18	syndromes	syndrome	NNS
cord-270892-ycc3csyh	552	19	than	than	IN
cord-270892-ycc3csyh	552	20	the	the	DT
cord-270892-ycc3csyh	552	21	placebo	placebo	NN
cord-270892-ycc3csyh	552	22	group	group	NN
cord-270892-ycc3csyh	552	23	(	(	-LRB-
cord-270892-ycc3csyh	552	24	32	32	CD
cord-270892-ycc3csyh	552	25	vs.	vs.	NN
cord-270892-ycc3csyh	552	26	62	62	CD
cord-270892-ycc3csyh	552	27	%	%	NN
cord-270892-ycc3csyh	552	28	)	)	-RRB-
cord-270892-ycc3csyh	552	29	.	.	.
cord-270892-ycc3csyh	553	1	Additionally	additionally	RB
cord-270892-ycc3csyh	553	2	,	,	,
cord-270892-ycc3csyh	553	3	the	the	DT
cord-270892-ycc3csyh	553	4	duration	duration	NN
cord-270892-ycc3csyh	553	5	of	of	IN
cord-270892-ycc3csyh	553	6	respiratory	respiratory	JJ
cord-270892-ycc3csyh	553	7	symptoms	symptom	NNS
cord-270892-ycc3csyh	553	8	was	be	VBD
cord-270892-ycc3csyh	553	9	reduced	reduce	VBN
cord-270892-ycc3csyh	553	10	by	by	IN
cord-270892-ycc3csyh	553	11	55	55	CD
cord-270892-ycc3csyh	553	12	%	%	NN
cord-270892-ycc3csyh	553	13	in	in	IN
cord-270892-ycc3csyh	553	14	the	the	DT
cord-270892-ycc3csyh	553	15	ginseng	ginseng	NN
cord-270892-ycc3csyh	553	16	group	group	NN
cord-270892-ycc3csyh	553	17	.	.	.
cord-270892-ycc3csyh	554	1	291	291	CD
cord-270892-ycc3csyh	555	1	In	in	IN
cord-270892-ycc3csyh	555	2	a	a	DT
cord-270892-ycc3csyh	555	3	similarly	similarly	RB
cord-270892-ycc3csyh	555	4	arranged	arrange	VBN
cord-270892-ycc3csyh	555	5	trial	trial	NN
cord-270892-ycc3csyh	555	6	,	,	,
cord-270892-ycc3csyh	555	7	323	323	CD
cord-270892-ycc3csyh	555	8	healthy	healthy	JJ
cord-270892-ycc3csyh	555	9	adults	adult	NNS
cord-270892-ycc3csyh	555	10	(	(	-LRB-
cord-270892-ycc3csyh	555	11	ages	age	NNS
cord-270892-ycc3csyh	555	12	18	18	CD
cord-270892-ycc3csyh	555	13	-	-	SYM
cord-270892-ycc3csyh	555	14	65	65	CD
cord-270892-ycc3csyh	555	15	years	year	NNS
cord-270892-ycc3csyh	555	16	)	)	-RRB-
cord-270892-ycc3csyh	555	17	with	with	IN
cord-270892-ycc3csyh	555	18	a	a	DT
cord-270892-ycc3csyh	555	19	history	history	NN
cord-270892-ycc3csyh	555	20	of	of	IN
cord-270892-ycc3csyh	555	21	at	at	RB
cord-270892-ycc3csyh	555	22	least	least	RBS
cord-270892-ycc3csyh	555	23	two	two	CD
cord-270892-ycc3csyh	555	24	colds	cold	NNS
cord-270892-ycc3csyh	555	25	the	the	DT
cord-270892-ycc3csyh	555	26	previous	previous	JJ
cord-270892-ycc3csyh	555	27	year	year	NN
cord-270892-ycc3csyh	555	28	commenced	commence	VBD
cord-270892-ycc3csyh	555	29	a	a	DT
cord-270892-ycc3csyh	555	30	4	4	CD
cord-270892-ycc3csyh	555	31	month	month	NN
cord-270892-ycc3csyh	555	32	study	study	NN
cord-270892-ycc3csyh	555	33	at	at	IN
cord-270892-ycc3csyh	555	34	the	the	DT
cord-270892-ycc3csyh	555	35	beginning	beginning	NN
cord-270892-ycc3csyh	555	36	of	of	IN
cord-270892-ycc3csyh	555	37	a	a	DT
cord-270892-ycc3csyh	555	38	cold	cold	JJ
cord-270892-ycc3csyh	555	39	and	and	CC
cord-270892-ycc3csyh	555	40	flu	flu	NN
cord-270892-ycc3csyh	555	41	season	season	NN
cord-270892-ycc3csyh	555	42	.	.	.
cord-270892-ycc3csyh	556	1	292	292	CD
cord-270892-ycc3csyh	557	1	They	-PRON-	PRP
cord-270892-ycc3csyh	557	2	received	receive	VBD
cord-270892-ycc3csyh	557	3	two	two	CD
cord-270892-ycc3csyh	557	4	200	200	CD
cord-270892-ycc3csyh	557	5	mg	mg	NNP
cord-270892-ycc3csyh	557	6	capsules	capsule	NNS
cord-270892-ycc3csyh	557	7	daily	daily	RB
cord-270892-ycc3csyh	557	8	of	of	IN
cord-270892-ycc3csyh	557	9	standardized	standardized	JJ
cord-270892-ycc3csyh	557	10	American	american	JJ
cord-270892-ycc3csyh	557	11	ginseng	ginseng	NN
cord-270892-ycc3csyh	557	12	root	root	NN
cord-270892-ycc3csyh	557	13	extract	extract	NN
cord-270892-ycc3csyh	557	14	or	or	CC
cord-270892-ycc3csyh	557	15	a	a	DT
cord-270892-ycc3csyh	557	16	placebo	placebo	NN
cord-270892-ycc3csyh	557	17	.	.	.
cord-270892-ycc3csyh	558	1	Outcomes	outcome	NNS
cord-270892-ycc3csyh	558	2	measured	measure	VBN
cord-270892-ycc3csyh	558	3	were	be	VBD
cord-270892-ycc3csyh	558	4	number	number	NN
cord-270892-ycc3csyh	558	5	of	of	IN
cord-270892-ycc3csyh	558	6	colds	cold	NNS
cord-270892-ycc3csyh	558	7	including	include	VBG
cord-270892-ycc3csyh	558	8	symptom	symptom	NN
cord-270892-ycc3csyh	558	9	severity	severity	NN
cord-270892-ycc3csyh	558	10	and	and	CC
cord-270892-ycc3csyh	558	11	total	total	JJ
cord-270892-ycc3csyh	558	12	number	number	NN
cord-270892-ycc3csyh	558	13	of	of	IN
cord-270892-ycc3csyh	558	14	symptomatic	symptomatic	JJ
cord-270892-ycc3csyh	558	15	days	day	NNS
cord-270892-ycc3csyh	558	16	.	.	.
cord-270892-ycc3csyh	559	1	A	a	DT
cord-270892-ycc3csyh	559	2	therapeutic	therapeutic	JJ
cord-270892-ycc3csyh	559	3	effect	effect	NN
cord-270892-ycc3csyh	559	4	was	be	VBD
cord-270892-ycc3csyh	559	5	reported	report	VBN
cord-270892-ycc3csyh	559	6	regarding	regard	VBG
cord-270892-ycc3csyh	559	7	symptom	symptom	NN
cord-270892-ycc3csyh	559	8	severity	severity	NN
cord-270892-ycc3csyh	559	9	and	and	CC
cord-270892-ycc3csyh	559	10	fewer	few	JJR
cord-270892-ycc3csyh	559	11	symptom	symptom	NN
cord-270892-ycc3csyh	559	12	days	day	NNS
cord-270892-ycc3csyh	559	13	that	that	WDT
cord-270892-ycc3csyh	559	14	were	be	VBD
cord-270892-ycc3csyh	559	15	31	31	CD
cord-270892-ycc3csyh	559	16	and	and	CC
cord-270892-ycc3csyh	559	17	34.5	34.5	CD
cord-270892-ycc3csyh	559	18	%	%	NN
cord-270892-ycc3csyh	559	19	lower	low	JJR
cord-270892-ycc3csyh	559	20	in	in	IN
cord-270892-ycc3csyh	559	21	the	the	DT
cord-270892-ycc3csyh	559	22	ginseng	ginseng	NN
cord-270892-ycc3csyh	559	23	group	group	NN
cord-270892-ycc3csyh	559	24	than	than	IN
cord-270892-ycc3csyh	559	25	in	in	IN
cord-270892-ycc3csyh	559	26	the	the	DT
cord-270892-ycc3csyh	559	27	placebo	placebo	NN
cord-270892-ycc3csyh	559	28	group	group	NN
cord-270892-ycc3csyh	559	29	.	.	.
cord-270892-ycc3csyh	560	1	A	a	DT
cord-270892-ycc3csyh	560	2	phase	phase	NN
cord-270892-ycc3csyh	560	3	II	ii	CD
cord-270892-ycc3csyh	560	4	randomized	randomized	JJ
cord-270892-ycc3csyh	560	5	,	,	,
cord-270892-ycc3csyh	560	6	controlled	control	VBN
cord-270892-ycc3csyh	560	7	trial	trial	NN
cord-270892-ycc3csyh	560	8	of	of	IN
cord-270892-ycc3csyh	560	9	2	2	CD
cord-270892-ycc3csyh	560	10	dosing	dosing	NN
cord-270892-ycc3csyh	560	11	schedules	schedule	NNS
cord-270892-ycc3csyh	560	12	of	of	IN
cord-270892-ycc3csyh	560	13	American	american	JJ
cord-270892-ycc3csyh	560	14	ginseng	ginseng	NN
cord-270892-ycc3csyh	560	15	root	root	NN
cord-270892-ycc3csyh	560	16	extracts	extract	NNS
cord-270892-ycc3csyh	560	17	,	,	,
cord-270892-ycc3csyh	560	18	rich	rich	JJ
cord-270892-ycc3csyh	560	19	in	in	IN
cord-270892-ycc3csyh	560	20	poly	poly	JJ
cord-270892-ycc3csyh	560	21	-	-	HYPH
cord-270892-ycc3csyh	560	22	furanosyl	furanosyl	JJ
cord-270892-ycc3csyh	560	23	-	-	HYPH
cord-270892-ycc3csyh	560	24	pyranosyl	pyranosyl	NN
cord-270892-ycc3csyh	560	25	-	-	HYPH
cord-270892-ycc3csyh	560	26	saccharides	saccharide	NNS
cord-270892-ycc3csyh	560	27	,	,	,
cord-270892-ycc3csyh	560	28	evaluated	evaluate	VBD
cord-270892-ycc3csyh	560	29	the	the	DT
cord-270892-ycc3csyh	560	30	safety	safety	NN
cord-270892-ycc3csyh	560	31	,	,	,
cord-270892-ycc3csyh	560	32	tolerability	tolerability	NN
cord-270892-ycc3csyh	560	33	,	,	,
cord-270892-ycc3csyh	560	34	and	and	CC
cord-270892-ycc3csyh	560	35	efficacy	efficacy	NN
cord-270892-ycc3csyh	560	36	in	in	IN
cord-270892-ycc3csyh	560	37	a	a	DT
cord-270892-ycc3csyh	560	38	pediatric	pediatric	JJ
cord-270892-ycc3csyh	560	39	population	population	NN
cord-270892-ycc3csyh	560	40	already	already	RB
cord-270892-ycc3csyh	560	41	suffering	suffer	VBG
cord-270892-ycc3csyh	560	42	from	from	IN
cord-270892-ycc3csyh	560	43	an	an	DT
cord-270892-ycc3csyh	560	44	upper	upper	JJ
cord-270892-ycc3csyh	560	45	respiratory	respiratory	JJ
cord-270892-ycc3csyh	560	46	tract	tract	NN
cord-270892-ycc3csyh	560	47	infection	infection	NN
cord-270892-ycc3csyh	560	48	.	.	.
cord-270892-ycc3csyh	561	1	The	the	DT
cord-270892-ycc3csyh	561	2	results	result	NNS
cord-270892-ycc3csyh	561	3	showed	show	VBD
cord-270892-ycc3csyh	561	4	no	no	DT
cord-270892-ycc3csyh	561	5	serious	serious	JJ
cord-270892-ycc3csyh	561	6	adverse	adverse	JJ
cord-270892-ycc3csyh	561	7	events	event	NNS
cord-270892-ycc3csyh	561	8	and	and	CC
cord-270892-ycc3csyh	561	9	a	a	DT
cord-270892-ycc3csyh	561	10	good	good	JJ
cord-270892-ycc3csyh	561	11	tolerability	tolerability	NN
cord-270892-ycc3csyh	561	12	of	of	IN
cord-270892-ycc3csyh	561	13	both	both	DT
cord-270892-ycc3csyh	561	14	ginseng	ginseng	NN
cord-270892-ycc3csyh	561	15	doses	dose	NNS
cord-270892-ycc3csyh	561	16	;	;	:
cord-270892-ycc3csyh	561	17	however	however	RB
cord-270892-ycc3csyh	561	18	,	,	,
cord-270892-ycc3csyh	561	19	frequency	frequency	NN
cord-270892-ycc3csyh	561	20	and	and	CC
cord-270892-ycc3csyh	561	21	severity	severity	NN
cord-270892-ycc3csyh	561	22	of	of	IN
cord-270892-ycc3csyh	561	23	symptoms	symptom	NNS
cord-270892-ycc3csyh	561	24	were	be	VBD
cord-270892-ycc3csyh	561	25	not	not	RB
cord-270892-ycc3csyh	561	26	significantly	significantly	RB
cord-270892-ycc3csyh	561	27	different	different	JJ
cord-270892-ycc3csyh	561	28	among	among	IN
cord-270892-ycc3csyh	561	29	each	each	DT
cord-270892-ycc3csyh	561	30	of	of	IN
cord-270892-ycc3csyh	561	31	the	the	DT
cord-270892-ycc3csyh	561	32	three	three	CD
cord-270892-ycc3csyh	561	33	treatment	treatment	NN
cord-270892-ycc3csyh	561	34	groups	group	NNS
cord-270892-ycc3csyh	561	35	,	,	,
cord-270892-ycc3csyh	561	36	i.e.	i.e.	FW
cord-270892-ycc3csyh	561	37	standard	standard	JJ
cord-270892-ycc3csyh	561	38	dose	dose	NN
cord-270892-ycc3csyh	561	39	,	,	,
cord-270892-ycc3csyh	561	40	low	low	JJ
cord-270892-ycc3csyh	561	41	dose	dose	NN
cord-270892-ycc3csyh	561	42	,	,	,
cord-270892-ycc3csyh	561	43	and	and	CC
cord-270892-ycc3csyh	561	44	placebo	placebo	NN
cord-270892-ycc3csyh	561	45	.	.	.
cord-270892-ycc3csyh	562	1	293	293	CD
cord-270892-ycc3csyh	563	1	The	the	DT
cord-270892-ycc3csyh	563	2	most	most	RBS
cord-270892-ycc3csyh	563	3	prominent	prominent	JJ
cord-270892-ycc3csyh	563	4	constituents	constituent	NNS
cord-270892-ycc3csyh	563	5	of	of	IN
cord-270892-ycc3csyh	563	6	the	the	DT
cord-270892-ycc3csyh	563	7	genus	genus	JJ
cord-270892-ycc3csyh	563	8	Panax	Panax	NNP
cord-270892-ycc3csyh	563	9	are	be	VBP
cord-270892-ycc3csyh	563	10	the	the	DT
cord-270892-ycc3csyh	563	11	triterpene	triterpene	NNP
cord-270892-ycc3csyh	563	12	saponins	saponin	NNS
cord-270892-ycc3csyh	563	13	ginsenosides	ginsenoside	NNS
cord-270892-ycc3csyh	563	14	.	.	.
cord-270892-ycc3csyh	564	1	They	-PRON-	PRP
cord-270892-ycc3csyh	564	2	are	be	VBP
cord-270892-ycc3csyh	564	3	known	know	VBN
cord-270892-ycc3csyh	564	4	to	to	TO
cord-270892-ycc3csyh	564	5	have	have	VB
cord-270892-ycc3csyh	564	6	numerous	numerous	JJ
cord-270892-ycc3csyh	564	7	pharmacological	pharmacological	JJ
cord-270892-ycc3csyh	564	8	activities	activity	NNS
cord-270892-ycc3csyh	564	9	such	such	JJ
cord-270892-ycc3csyh	564	10	as	as	IN
cord-270892-ycc3csyh	564	11	anti	anti	JJ
cord-270892-ycc3csyh	564	12	-	-	JJ
cord-270892-ycc3csyh	564	13	cancer	cancer	JJ
cord-270892-ycc3csyh	564	14	,	,	,
cord-270892-ycc3csyh	564	15	anti	anti	JJ
cord-270892-ycc3csyh	564	16	-	-	JJ
cord-270892-ycc3csyh	564	17	diabetes	diabetes	JJ
cord-270892-ycc3csyh	564	18	,	,	,
cord-270892-ycc3csyh	564	19	antiviral	antiviral	JJ
cord-270892-ycc3csyh	564	20	,	,	,
cord-270892-ycc3csyh	564	21	and	and	CC
cord-270892-ycc3csyh	564	22	anti	anti	JJ
cord-270892-ycc3csyh	564	23	-	-	JJ
cord-270892-ycc3csyh	564	24	atherosclerosis	atherosclerosis	JJ
cord-270892-ycc3csyh	564	25	effects	effect	NNS
cord-270892-ycc3csyh	564	26	.	.	.
cord-270892-ycc3csyh	565	1	Some	some	DT
cord-270892-ycc3csyh	565	2	compounds	compound	NNS
cord-270892-ycc3csyh	565	3	of	of	IN
cord-270892-ycc3csyh	565	4	this	this	DT
cord-270892-ycc3csyh	565	5	chemical	chemical	JJ
cord-270892-ycc3csyh	565	6	class	class	NN
cord-270892-ycc3csyh	565	7	showed	show	VBD
cord-270892-ycc3csyh	565	8	to	to	TO
cord-270892-ycc3csyh	565	9	be	be	VB
cord-270892-ycc3csyh	565	10	responsible	responsible	JJ
cord-270892-ycc3csyh	565	11	for	for	IN
cord-270892-ycc3csyh	565	12	the	the	DT
cord-270892-ycc3csyh	565	13	immunostimulant	immunostimulant	JJ
cord-270892-ycc3csyh	565	14	activity	activity	NN
cord-270892-ycc3csyh	565	15	of	of	IN
cord-270892-ycc3csyh	565	16	ginseng	ginseng	NN
cord-270892-ycc3csyh	565	17	.	.	.
cord-270892-ycc3csyh	566	1	294	294	CD
cord-270892-ycc3csyh	567	1	On	on	IN
cord-270892-ycc3csyh	567	2	the	the	DT
cord-270892-ycc3csyh	567	3	other	other	JJ
cord-270892-ycc3csyh	567	4	hand	hand	NN
cord-270892-ycc3csyh	567	5	,	,	,
cord-270892-ycc3csyh	567	6	the	the	DT
cord-270892-ycc3csyh	567	7	efficacy	efficacy	NN
cord-270892-ycc3csyh	567	8	of	of	IN
cord-270892-ycc3csyh	567	9	a	a	DT
cord-270892-ycc3csyh	567	10	polysaccharide	polysaccharide	NN
cord-270892-ycc3csyh	567	11	-	-	HYPH
cord-270892-ycc3csyh	567	12	rich	rich	JJ
cord-270892-ycc3csyh	567	13	extract	extract	NN
cord-270892-ycc3csyh	567	14	of	of	IN
cord-270892-ycc3csyh	567	15	American	american	JJ
cord-270892-ycc3csyh	567	16	ginseng	ginseng	NN
cord-270892-ycc3csyh	567	17	was	be	VBD
cord-270892-ycc3csyh	567	18	compared	compare	VBN
cord-270892-ycc3csyh	567	19	with	with	IN
cord-270892-ycc3csyh	567	20	an	an	DT
cord-270892-ycc3csyh	567	21	extract	extract	NN
cord-270892-ycc3csyh	567	22	rich	rich	JJ
cord-270892-ycc3csyh	567	23	in	in	IN
cord-270892-ycc3csyh	567	24	ginsenosides	ginsenoside	NNS
cord-270892-ycc3csyh	567	25	on	on	IN
cord-270892-ycc3csyh	567	26	systemic	systemic	JJ
cord-270892-ycc3csyh	567	27	and	and	CC
cord-270892-ycc3csyh	567	28	gut	gut	NN
cord-270892-ycc3csyh	567	29	-	-	HYPH
cord-270892-ycc3csyh	567	30	associated	associate	VBN
cord-270892-ycc3csyh	567	31	immune	immune	JJ
cord-270892-ycc3csyh	567	32	function	function	NN
cord-270892-ycc3csyh	567	33	.	.	.
cord-270892-ycc3csyh	568	1	The	the	DT
cord-270892-ycc3csyh	568	2	authors	author	NNS
cord-270892-ycc3csyh	568	3	of	of	IN
cord-270892-ycc3csyh	568	4	this	this	DT
cord-270892-ycc3csyh	568	5	study	study	NN
cord-270892-ycc3csyh	568	6	investigated	investigate	VBD
cord-270892-ycc3csyh	568	7	the	the	DT
cord-270892-ycc3csyh	568	8	lymphocytes	lymphocyte	NNS
cord-270892-ycc3csyh	568	9	isolated	isolate	VBN
cord-270892-ycc3csyh	568	10	from	from	IN
cord-270892-ycc3csyh	568	11	spleen	spleen	NN
cord-270892-ycc3csyh	568	12	,	,	,
cord-270892-ycc3csyh	568	13	mesenteric	mesenteric	JJ
cord-270892-ycc3csyh	568	14	lymph	lymph	NN
cord-270892-ycc3csyh	568	15	nodes	node	NNS
cord-270892-ycc3csyh	568	16	and	and	CC
cord-270892-ycc3csyh	568	17	Peyer	Peyer	NNP
cord-270892-ycc3csyh	568	18	's	's	POS
cord-270892-ycc3csyh	568	19	patches	patch	NNS
cord-270892-ycc3csyh	568	20	,	,	,
cord-270892-ycc3csyh	568	21	and	and	CC
cord-270892-ycc3csyh	568	22	immune	immune	JJ
cord-270892-ycc3csyh	568	23	cell	cell	NN
cord-270892-ycc3csyh	568	24	proportions	proportion	NNS
cord-270892-ycc3csyh	568	25	and	and	CC
cord-270892-ycc3csyh	568	26	cytokine	cytokine	NN
cord-270892-ycc3csyh	568	27	production	production	NN
cord-270892-ycc3csyh	568	28	from	from	IN
cord-270892-ycc3csyh	568	29	Sprague	Sprague	NNP
cord-270892-ycc3csyh	568	30	-	-	HYPH
cord-270892-ycc3csyh	568	31	Dawley	Dawley	NNP
cord-270892-ycc3csyh	568	32	rats	rat	NNS
cord-270892-ycc3csyh	568	33	.	.	.
cord-270892-ycc3csyh	569	1	They	-PRON-	PRP
cord-270892-ycc3csyh	569	2	could	could	MD
cord-270892-ycc3csyh	569	3	show	show	VB
cord-270892-ycc3csyh	569	4	that	that	IN
cord-270892-ycc3csyh	569	5	the	the	DT
cord-270892-ycc3csyh	569	6	polysaccharide	polysaccharide	NN
cord-270892-ycc3csyh	569	7	-	-	HYPH
cord-270892-ycc3csyh	569	8	rich	rich	JJ
cord-270892-ycc3csyh	569	9	ginseng	ginseng	NN
cord-270892-ycc3csyh	569	10	extract	extract	NN
cord-270892-ycc3csyh	569	11	modifies	modify	VBZ
cord-270892-ycc3csyh	569	12	the	the	DT
cord-270892-ycc3csyh	569	13	rats	rat	NNS
cord-270892-ycc3csyh	569	14	'	'	POS
cord-270892-ycc3csyh	569	15	systemic	systemic	JJ
cord-270892-ycc3csyh	569	16	immune	immune	JJ
cord-270892-ycc3csyh	569	17	responses	response	NNS
cord-270892-ycc3csyh	569	18	and	and	CC
cord-270892-ycc3csyh	569	19	affects	affect	VBZ
cord-270892-ycc3csyh	569	20	the	the	DT
cord-270892-ycc3csyh	569	21	gut	gut	NN
cord-270892-ycc3csyh	569	22	-	-	HYPH
cord-270892-ycc3csyh	569	23	associated	associate	VBN
cord-270892-ycc3csyh	569	24	immunity	immunity	NN
cord-270892-ycc3csyh	569	25	in	in	IN
cord-270892-ycc3csyh	569	26	a	a	DT
cord-270892-ycc3csyh	569	27	manner	manner	NN
cord-270892-ycc3csyh	569	28	distinct	distinct	JJ
cord-270892-ycc3csyh	569	29	from	from	IN
cord-270892-ycc3csyh	569	30	that	that	DT
cord-270892-ycc3csyh	569	31	of	of	IN
cord-270892-ycc3csyh	569	32	the	the	DT
cord-270892-ycc3csyh	569	33	ginsenoside	ginsenoside	NN
cord-270892-ycc3csyh	569	34	-	-	HYPH
cord-270892-ycc3csyh	569	35	containing	contain	VBG
cord-270892-ycc3csyh	569	36	extract	extract	NN
cord-270892-ycc3csyh	569	37	of	of	IN
cord-270892-ycc3csyh	569	38	American	american	JJ
cord-270892-ycc3csyh	569	39	ginseng	ginseng	NN
cord-270892-ycc3csyh	569	40	.	.	.
cord-270892-ycc3csyh	570	1	295	295	CD
cord-270892-ycc3csyh	571	1	A	a	DT
cord-270892-ycc3csyh	571	2	direct	direct	JJ
cord-270892-ycc3csyh	571	3	antiviral	antiviral	JJ
cord-270892-ycc3csyh	571	4	activity	activity	NN
cord-270892-ycc3csyh	571	5	of	of	IN
cord-270892-ycc3csyh	571	6	ginseng	ginseng	NN
cord-270892-ycc3csyh	571	7	constituents	constituent	NNS
cord-270892-ycc3csyh	571	8	could	could	MD
cord-270892-ycc3csyh	571	9	be	be	VB
cord-270892-ycc3csyh	571	10	attested	attest	VBN
cord-270892-ycc3csyh	571	11	for	for	IN
cord-270892-ycc3csyh	571	12	the	the	DT
cord-270892-ycc3csyh	571	13	polysaccharides	polysaccharide	NNS
cord-270892-ycc3csyh	571	14	on	on	IN
cord-270892-ycc3csyh	571	15	rotavirus	rotavirus	JJ
cord-270892-ycc3csyh	571	16	infection	infection	NN
cord-270892-ycc3csyh	571	17	in	in	IN
cord-270892-ycc3csyh	571	18	MA104	MA104	NNP
cord-270892-ycc3csyh	571	19	cells	cell	NNS
cord-270892-ycc3csyh	571	20	.	.	.
cord-270892-ycc3csyh	572	1	The	the	DT
cord-270892-ycc3csyh	572	2	triterpene	triterpene	JJ
cord-270892-ycc3csyh	572	3	saponins	saponin	NNS
cord-270892-ycc3csyh	572	4	,	,	,
cord-270892-ycc3csyh	572	5	however	however	RB
cord-270892-ycc3csyh	572	6	,	,	,
cord-270892-ycc3csyh	572	7	did	do	VBD
cord-270892-ycc3csyh	572	8	not	not	RB
cord-270892-ycc3csyh	572	9	exhibit	exhibit	VB
cord-270892-ycc3csyh	572	10	any	any	DT
cord-270892-ycc3csyh	572	11	rotavirus	rotavirus	JJ
cord-270892-ycc3csyh	572	12	infection	infection	NN
cord-270892-ycc3csyh	572	13	-	-	HYPH
cord-270892-ycc3csyh	572	14	inhibitory	inhibitory	JJ
cord-270892-ycc3csyh	572	15	activity	activity	NN
cord-270892-ycc3csyh	572	16	in	in	IN
cord-270892-ycc3csyh	572	17	this	this	DT
cord-270892-ycc3csyh	572	18	study	study	NN
cord-270892-ycc3csyh	572	19	.	.	.
cord-270892-ycc3csyh	573	1	296	296	CD
cord-270892-ycc3csyh	574	1	A	a	DT
cord-270892-ycc3csyh	574	2	moderate	moderate	JJ
cord-270892-ycc3csyh	574	3	in	in	IN
cord-270892-ycc3csyh	574	4	vitro	vitro	FW
cord-270892-ycc3csyh	574	5	virucidal	virucidal	JJ
cord-270892-ycc3csyh	574	6	effect	effect	NN
cord-270892-ycc3csyh	574	7	(	(	-LRB-
cord-270892-ycc3csyh	574	8	ID	ID	NNP
cord-270892-ycc3csyh	574	9	50	50	CD
cord-270892-ycc3csyh	574	10	62	62	CD
cord-270892-ycc3csyh	574	11	mM	mm	CD
cord-270892-ycc3csyh	574	12	)	)	-RRB-
cord-270892-ycc3csyh	574	13	of	of	IN
cord-270892-ycc3csyh	574	14	the	the	DT
cord-270892-ycc3csyh	574	15	ginseng	ginseng	NN
cord-270892-ycc3csyh	574	16	saponin	saponin	NN
cord-270892-ycc3csyh	574	17	chikusetsusaponin	chikusetsusaponin	NNP
cord-270892-ycc3csyh	574	18	III	III	NNP
cord-270892-ycc3csyh	574	19	against	against	IN
cord-270892-ycc3csyh	574	20	herpes	herpes	NNP
cord-270892-ycc3csyh	574	21	simplex	simplex	NNP
cord-270892-ycc3csyh	574	22	virus	virus	NN
cord-270892-ycc3csyh	574	23	type	type	NN
cord-270892-ycc3csyh	575	1	I	-PRON-	PRP
cord-270892-ycc3csyh	575	2	was	be	VBD
cord-270892-ycc3csyh	575	3	detected	detect	VBN
cord-270892-ycc3csyh	575	4	by	by	IN
cord-270892-ycc3csyh	575	5	Fukushima	Fukushima	NNP
cord-270892-ycc3csyh	575	6	et	et	NNP
cord-270892-ycc3csyh	575	7	al	al	NNP
cord-270892-ycc3csyh	575	8	.	.	.
cord-270892-ycc3csyh	576	1	This	this	DT
cord-270892-ycc3csyh	576	2	compound	compound	NN
cord-270892-ycc3csyh	576	3	exhibited	exhibit	VBD
cord-270892-ycc3csyh	576	4	an	an	DT
cord-270892-ycc3csyh	576	5	intracellular	intracellular	JJ
cord-270892-ycc3csyh	576	6	inhibitory	inhibitory	JJ
cord-270892-ycc3csyh	576	7	activity	activity	NN
cord-270892-ycc3csyh	576	8	,	,	,
cord-270892-ycc3csyh	576	9	but	but	CC
cord-270892-ycc3csyh	576	10	could	could	MD
cord-270892-ycc3csyh	576	11	only	only	RB
cord-270892-ycc3csyh	576	12	marginally	marginally	RB
cord-270892-ycc3csyh	576	13	affect	affect	VB
cord-270892-ycc3csyh	576	14	the	the	DT
cord-270892-ycc3csyh	576	15	viral	viral	JJ
cord-270892-ycc3csyh	576	16	proteins	protein	NNS
cord-270892-ycc3csyh	576	17	postinfection	postinfection	NN
cord-270892-ycc3csyh	576	18	.	.	.
cord-270892-ycc3csyh	577	1	297	297	CD
cord-270892-ycc3csyh	577	2	 	 	_SP
cord-270892-ycc3csyh	578	1	The	the	DT
cord-270892-ycc3csyh	578	2	ancient	ancient	JJ
cord-270892-ycc3csyh	578	3	Chinese	chinese	JJ
cord-270892-ycc3csyh	578	4	formula	formula	NN
cord-270892-ycc3csyh	578	5	Bu	Bu	NNP
cord-270892-ycc3csyh	578	6	-	-	HYPH
cord-270892-ycc3csyh	578	7	zhong	zhong	NNP
cord-270892-ycc3csyh	578	8	-	-	HYPH
cord-270892-ycc3csyh	578	9	yi	yi	NNP
cord-270892-ycc3csyh	578	10	-	-	HYPH
cord-270892-ycc3csyh	578	11	qi	qi	NNP
cord-270892-ycc3csyh	578	12	-	-	HYPH
cord-270892-ycc3csyh	578	13	tang	tang	NNP
cord-270892-ycc3csyh	579	1	(	(	-LRB-
cord-270892-ycc3csyh	579	2	Japanese	japanese	JJ
cord-270892-ycc3csyh	579	3	name	name	NN
cord-270892-ycc3csyh	579	4	Hochu	Hochu	NNP
cord-270892-ycc3csyh	579	5	-	-	HYPH
cord-270892-ycc3csyh	579	6	ekki	ekki	NNP
cord-270892-ycc3csyh	579	7	-	-	HYPH
cord-270892-ycc3csyh	579	8	to	to	IN
cord-270892-ycc3csyh	579	9	)	)	-RRB-
cord-270892-ycc3csyh	579	10	is	be	VBZ
cord-270892-ycc3csyh	579	11	a	a	DT
cord-270892-ycc3csyh	579	12	traditional	traditional	JJ
cord-270892-ycc3csyh	579	13	herbal	herbal	JJ
cord-270892-ycc3csyh	579	14	medicine	medicine	NN
cord-270892-ycc3csyh	579	15	in	in	IN
cord-270892-ycc3csyh	579	16	China	China	NNP
cord-270892-ycc3csyh	579	17	and	and	CC
cord-270892-ycc3csyh	579	18	Japan	Japan	NNP
cord-270892-ycc3csyh	579	19	that	that	WDT
cord-270892-ycc3csyh	579	20	is	be	VBZ
cord-270892-ycc3csyh	579	21	composed	compose	VBN
cord-270892-ycc3csyh	579	22	of	of	IN
cord-270892-ycc3csyh	579	23	ten	ten	CD
cord-270892-ycc3csyh	579	24	species	specie	NNS
cord-270892-ycc3csyh	579	25	of	of	IN
cord-270892-ycc3csyh	579	26	medicinal	medicinal	JJ
cord-270892-ycc3csyh	579	27	plants	plant	NNS
cord-270892-ycc3csyh	579	28	,	,	,
cord-270892-ycc3csyh	579	29	namely	namely	RB
cord-270892-ycc3csyh	579	30	Astragali	astragali	NN
cord-270892-ycc3csyh	579	31	radix	radix	NN
cord-270892-ycc3csyh	579	32	,	,	,
cord-270892-ycc3csyh	579	33	Atractylodis	Atractylodis	NNP
cord-270892-ycc3csyh	579	34	lanceae	lanceae	NN
cord-270892-ycc3csyh	579	35	rhizoma	rhizoma	NN
cord-270892-ycc3csyh	579	36	,	,	,
cord-270892-ycc3csyh	579	37	Ginseng	Ginseng	NNP
cord-270892-ycc3csyh	579	38	radix	radix	NN
cord-270892-ycc3csyh	579	39	,	,	,
cord-270892-ycc3csyh	579	40	Angelicae	Angelicae	NNP
cord-270892-ycc3csyh	579	41	radix	radix	NN
cord-270892-ycc3csyh	579	42	,	,	,
cord-270892-ycc3csyh	579	43	Bupleuri	Bupleuri	NNP
cord-270892-ycc3csyh	579	44	radix	radix	NN
cord-270892-ycc3csyh	579	45	,	,	,
cord-270892-ycc3csyh	579	46	Zizyphi	Zizyphi	NNP
cord-270892-ycc3csyh	579	47	fructus	fructus	NN
cord-270892-ycc3csyh	579	48	,	,	,
cord-270892-ycc3csyh	579	49	Aurantii	Aurantii	NNP
cord-270892-ycc3csyh	579	50	nobilis	nobilis	NN
cord-270892-ycc3csyh	579	51	pericarpium	pericarpium	NN
cord-270892-ycc3csyh	579	52	,	,	,
cord-270892-ycc3csyh	579	53	Glycyrrhizae	Glycyrrhizae	NNP
cord-270892-ycc3csyh	579	54	radix	radix	NN
cord-270892-ycc3csyh	579	55	,	,	,
cord-270892-ycc3csyh	579	56	Cimicifugae	Cimicifugae	NNP
cord-270892-ycc3csyh	579	57	rhizoma	rhizoma	NN
cord-270892-ycc3csyh	579	58	,	,	,
cord-270892-ycc3csyh	579	59	and	and	CC
cord-270892-ycc3csyh	579	60	Zingiberis	Zingiberis	NNP
cord-270892-ycc3csyh	579	61	rhizoma	rhizoma	NN
cord-270892-ycc3csyh	579	62	.	.	.
cord-270892-ycc3csyh	580	1	This	this	DT
cord-270892-ycc3csyh	580	2	formula	formula	NN
cord-270892-ycc3csyh	580	3	is	be	VBZ
cord-270892-ycc3csyh	580	4	reported	report	VBN
cord-270892-ycc3csyh	580	5	to	to	TO
cord-270892-ycc3csyh	580	6	have	have	VB
cord-270892-ycc3csyh	580	7	various	various	JJ
cord-270892-ycc3csyh	580	8	immunomodulatory	immunomodulatory	NN
cord-270892-ycc3csyh	580	9	,	,	,
cord-270892-ycc3csyh	580	10	[	[	-LRB-
cord-270892-ycc3csyh	580	11	298	298	CD
cord-270892-ycc3csyh	580	12	]	]	-RRB-
cord-270892-ycc3csyh	580	13	[	[	-LRB-
cord-270892-ycc3csyh	580	14	299	299	CD
cord-270892-ycc3csyh	580	15	]	]	-RRB-
cord-270892-ycc3csyh	580	16	[	[	-LRB-
cord-270892-ycc3csyh	580	17	300	300	CD
cord-270892-ycc3csyh	580	18	]	]	-RRB-
cord-270892-ycc3csyh	580	19	and	and	CC
cord-270892-ycc3csyh	580	20	anti	anti	JJ
cord-270892-ycc3csyh	580	21	-	-	JJ
cord-270892-ycc3csyh	580	22	inflammatory	inflammatory	JJ
cord-270892-ycc3csyh	580	23	activities	activity	NNS
cord-270892-ycc3csyh	580	24	.	.	.
cord-270892-ycc3csyh	581	1	301	301	CD
cord-270892-ycc3csyh	581	2	Yamaya	Yamaya	NNP
cord-270892-ycc3csyh	581	3	et	et	FW
cord-270892-ycc3csyh	581	4	al	al	NNP
cord-270892-ycc3csyh	581	5	.	.	.
cord-270892-ycc3csyh	582	1	recently	recently	RB
cord-270892-ycc3csyh	582	2	investigated	investigate	VBD
cord-270892-ycc3csyh	582	3	the	the	DT
cord-270892-ycc3csyh	582	4	effects	effect	NNS
cord-270892-ycc3csyh	582	5	of	of	IN
cord-270892-ycc3csyh	582	6	Hochu	Hochu	NNP
cord-270892-ycc3csyh	582	7	-	-	HYPH
cord-270892-ycc3csyh	582	8	ekki	ekki	NNP
cord-270892-ycc3csyh	582	9	-	-	:
cord-270892-ycc3csyh	582	10	to	to	IN
cord-270892-ycc3csyh	582	11	in	in	IN
cord-270892-ycc3csyh	582	12	cultures	culture	NNS
cord-270892-ycc3csyh	582	13	of	of	IN
cord-270892-ycc3csyh	582	14	human	human	JJ
cord-270892-ycc3csyh	582	15	airway	airway	NN
cord-270892-ycc3csyh	582	16	epithelial	epithelial	JJ
cord-270892-ycc3csyh	582	17	cells	cell	NNS
cord-270892-ycc3csyh	582	18	infected	infect	VBN
cord-270892-ycc3csyh	582	19	with	with	IN
cord-270892-ycc3csyh	582	20	HRV-14	HRV-14	NNP
cord-270892-ycc3csyh	582	21	.	.	.
cord-270892-ycc3csyh	583	1	302	302	CD
cord-270892-ycc3csyh	584	1	The	the	DT
cord-270892-ycc3csyh	584	2	output	output	NN
cord-270892-ycc3csyh	584	3	of	of	IN
cord-270892-ycc3csyh	584	4	virus	virus	NN
cord-270892-ycc3csyh	584	5	,	,	,
cord-270892-ycc3csyh	584	6	associated	associated	JJ
cord-270892-ycc3csyh	584	7	levels	level	NNS
cord-270892-ycc3csyh	584	8	of	of	IN
cord-270892-ycc3csyh	584	9	viral	viral	JJ
cord-270892-ycc3csyh	584	10	RNA	RNA	NNP
cord-270892-ycc3csyh	584	11	,	,	,
cord-270892-ycc3csyh	584	12	and	and	CC
cord-270892-ycc3csyh	584	13	the	the	DT
cord-270892-ycc3csyh	584	14	production	production	NN
cord-270892-ycc3csyh	584	15	of	of	IN
cord-270892-ycc3csyh	584	16	ICAM-1	icam-1	NN
cord-270892-ycc3csyh	584	17	,	,	,
cord-270892-ycc3csyh	584	18	cytokines	cytokine	NNS
cord-270892-ycc3csyh	584	19	and	and	CC
cord-270892-ycc3csyh	584	20	acidic	acidic	JJ
cord-270892-ycc3csyh	584	21	endosomes	endosome	NNS
cord-270892-ycc3csyh	584	22	in	in	IN
cord-270892-ycc3csyh	584	23	cells	cell	NNS
cord-270892-ycc3csyh	584	24	were	be	VBD
cord-270892-ycc3csyh	584	25	measured	measure	VBN
cord-270892-ycc3csyh	584	26	.	.	.
cord-270892-ycc3csyh	585	1	In	in	IN
cord-270892-ycc3csyh	585	2	airway	airway	NN
cord-270892-ycc3csyh	585	3	epithelial	epithelial	JJ
cord-270892-ycc3csyh	585	4	cells	cell	NNS
cord-270892-ycc3csyh	585	5	Hochu	Hochu	NNP
cord-270892-ycc3csyh	585	6	-	-	HYPH
cord-270892-ycc3csyh	585	7	ekki	ekki	NNP
cord-270892-ycc3csyh	585	8	-	-	HYPH
cord-270892-ycc3csyh	585	9	to	to	NNP
cord-270892-ycc3csyh	585	10	was	be	VBD
cord-270892-ycc3csyh	585	11	able	able	JJ
cord-270892-ycc3csyh	585	12	to	to	TO
cord-270892-ycc3csyh	585	13	decrease	decrease	VB
cord-270892-ycc3csyh	585	14	virus	virus	NN
cord-270892-ycc3csyh	585	15	output	output	NN
cord-270892-ycc3csyh	585	16	and	and	CC
cord-270892-ycc3csyh	585	17	susceptibility	susceptibility	NN
cord-270892-ycc3csyh	585	18	to	to	IN
cord-270892-ycc3csyh	585	19	HRV	HRV	NNP
cord-270892-ycc3csyh	585	20	infection	infection	NN
cord-270892-ycc3csyh	585	21	by	by	IN
cord-270892-ycc3csyh	585	22	decreasing	decrease	VBG
cord-270892-ycc3csyh	585	23	ICAM-1	ICAM-1	NNP
cord-270892-ycc3csyh	585	24	and	and	CC
cord-270892-ycc3csyh	585	25	by	by	IN
cord-270892-ycc3csyh	585	26	blocking	block	VBG
cord-270892-ycc3csyh	585	27	the	the	DT
cord-270892-ycc3csyh	585	28	entry	entry	NN
cord-270892-ycc3csyh	585	29	of	of	IN
cord-270892-ycc3csyh	585	30	viral	viral	JJ
cord-270892-ycc3csyh	585	31	RNA	RNA	NNP
cord-270892-ycc3csyh	585	32	into	into	IN
cord-270892-ycc3csyh	585	33	the	the	DT
cord-270892-ycc3csyh	585	34	cytoplasm	cytoplasm	NN
cord-270892-ycc3csyh	585	35	from	from	IN
cord-270892-ycc3csyh	585	36	the	the	DT
cord-270892-ycc3csyh	585	37	endosomes	endosome	NNS
cord-270892-ycc3csyh	585	38	.	.	.
cord-270892-ycc3csyh	586	1	Glycyrrhizin	Glycyrrhizin	NNP
cord-270892-ycc3csyh	586	2	,	,	,
cord-270892-ycc3csyh	586	3	a	a	DT
cord-270892-ycc3csyh	586	4	major	major	JJ
cord-270892-ycc3csyh	586	5	component	component	NN
cord-270892-ycc3csyh	586	6	of	of	IN
cord-270892-ycc3csyh	586	7	one	one	CD
cord-270892-ycc3csyh	586	8	herbal	herbal	JJ
cord-270892-ycc3csyh	586	9	ingredient	ingredient	NN
cord-270892-ycc3csyh	586	10	of	of	IN
cord-270892-ycc3csyh	586	11	Hochu	Hochu	NNP
cord-270892-ycc3csyh	586	12	-	-	HYPH
cord-270892-ycc3csyh	586	13	ekki	ekki	NNP
cord-270892-ycc3csyh	586	14	-	-	HYPH
cord-270892-ycc3csyh	586	15	to	to	TO
cord-270892-ycc3csyh	586	16	,	,	,
cord-270892-ycc3csyh	586	17	i.e.	i.e.	FW
cord-270892-ycc3csyh	586	18	Glycyrrhiza	Glycyrrhiza	NNP
cord-270892-ycc3csyh	586	19	glabra	glabra	NNP
cord-270892-ycc3csyh	586	20	,	,	,
cord-270892-ycc3csyh	586	21	was	be	VBD
cord-270892-ycc3csyh	586	22	able	able	JJ
cord-270892-ycc3csyh	586	23	to	to	TO
cord-270892-ycc3csyh	586	24	reduce	reduce	VB
cord-270892-ycc3csyh	586	25	supernatant	supernatant	JJ
cord-270892-ycc3csyh	586	26	virus	virus	NN
cord-270892-ycc3csyh	586	27	titers	titer	NNS
cord-270892-ycc3csyh	586	28	dose	dose	NN
cord-270892-ycc3csyh	586	29	-	-	HYPH
cord-270892-ycc3csyh	586	30	dependently	dependently	RB
cord-270892-ycc3csyh	586	31	,	,	,
cord-270892-ycc3csyh	586	32	with	with	IN
cord-270892-ycc3csyh	586	33	a	a	DT
cord-270892-ycc3csyh	586	34	maximum	maximum	JJ
cord-270892-ycc3csyh	586	35	effect	effect	NN
cord-270892-ycc3csyh	586	36	between	between	IN
cord-270892-ycc3csyh	586	37	0.12	0.12	CD
cord-270892-ycc3csyh	586	38	and	and	CC
cord-270892-ycc3csyh	586	39	0.6	0.6	CD
cord-270892-ycc3csyh	586	40	mM.	mm.	NN
cord-270892-ycc3csyh	587	1	However	however	RB
cord-270892-ycc3csyh	587	2	,	,	,
cord-270892-ycc3csyh	587	3	no	no	DT
cord-270892-ycc3csyh	587	4	clinical	clinical	JJ
cord-270892-ycc3csyh	587	5	trials	trial	NNS
cord-270892-ycc3csyh	587	6	with	with	IN
cord-270892-ycc3csyh	587	7	representative	representative	JJ
cord-270892-ycc3csyh	587	8	numbers	number	NNS
cord-270892-ycc3csyh	587	9	of	of	IN
cord-270892-ycc3csyh	587	10	subjects	subject	NNS
cord-270892-ycc3csyh	587	11	are	be	VBP
cord-270892-ycc3csyh	587	12	published	publish	VBN
cord-270892-ycc3csyh	587	13	so	so	RB
cord-270892-ycc3csyh	587	14	far	far	RB
cord-270892-ycc3csyh	587	15	.	.	.
cord-270892-ycc3csyh	588	1	THE	the	DT
cord-270892-ycc3csyh	588	2	HUMAN	HUMAN	NNP
cord-270892-ycc3csyh	588	3	RHINOVIRUS	RHINOVIRUS	NNP
cord-270892-ycc3csyh	588	4	K	K	NNP
cord-270892-ycc3csyh	588	5	63	63	CD
cord-270892-ycc3csyh	588	6	5	5	CD
cord-270892-ycc3csyh	588	7	.	.	.
cord-270892-ycc3csyh	589	1	Umckaloabo	Umckaloabo	NNP
cord-270892-ycc3csyh	589	2	(	(	-LRB-
cord-270892-ycc3csyh	589	3	Pelargonium	Pelargonium	NNP
cord-270892-ycc3csyh	589	4	sidoides	sidoide	NNS
cord-270892-ycc3csyh	589	5	)	)	-RRB-
cord-270892-ycc3csyh	590	1	P.	P.	NNP
cord-270892-ycc3csyh	590	2	sidoides	sidoides	NNP
cord-270892-ycc3csyh	590	3	and	and	CC
cord-270892-ycc3csyh	590	4	P.	P.	NNP
cord-270892-ycc3csyh	590	5	reniforme	reniforme	NN
cord-270892-ycc3csyh	590	6	form	form	VB
cord-270892-ycc3csyh	590	7	the	the	DT
cord-270892-ycc3csyh	590	8	origin	origin	NN
cord-270892-ycc3csyh	590	9	of	of	IN
cord-270892-ycc3csyh	590	10	the	the	DT
cord-270892-ycc3csyh	590	11	popular	popular	JJ
cord-270892-ycc3csyh	590	12	drug	drug	NN
cord-270892-ycc3csyh	590	13	Umckaloabo	Umckaloabo	NNP
cord-270892-ycc3csyh	590	14	.	.	.
cord-270892-ycc3csyh	591	1	This	this	DT
cord-270892-ycc3csyh	591	2	herbal	herbal	JJ
cord-270892-ycc3csyh	591	3	remedy	remedy	NN
cord-270892-ycc3csyh	591	4	from	from	IN
cord-270892-ycc3csyh	591	5	South	South	NNP
cord-270892-ycc3csyh	591	6	Africa	Africa	NNP
cord-270892-ycc3csyh	591	7	has	have	VBZ
cord-270892-ycc3csyh	591	8	found	find	VBN
cord-270892-ycc3csyh	591	9	entrance	entrance	NN
cord-270892-ycc3csyh	591	10	in	in	IN
cord-270892-ycc3csyh	591	11	Western	western	JJ
cord-270892-ycc3csyh	591	12	medicine	medicine	NN
cord-270892-ycc3csyh	591	13	mainly	mainly	RB
cord-270892-ycc3csyh	591	14	as	as	IN
cord-270892-ycc3csyh	591	15	aqueous	aqueous	JJ
cord-270892-ycc3csyh	591	16	ethanolic	ethanolic	JJ
cord-270892-ycc3csyh	591	17	root	root	NN
cord-270892-ycc3csyh	591	18	extract	extract	NN
cord-270892-ycc3csyh	591	19	from	from	IN
cord-270892-ycc3csyh	591	20	P.	P.	NNP
cord-270892-ycc3csyh	591	21	sidoides	sidoides	NNP
cord-270892-ycc3csyh	591	22	for	for	IN
cord-270892-ycc3csyh	591	23	the	the	DT
cord-270892-ycc3csyh	591	24	treatment	treatment	NN
cord-270892-ycc3csyh	591	25	of	of	IN
cord-270892-ycc3csyh	591	26	infections	infection	NNS
cord-270892-ycc3csyh	591	27	of	of	IN
cord-270892-ycc3csyh	591	28	the	the	DT
cord-270892-ycc3csyh	591	29	respiratory	respiratory	JJ
cord-270892-ycc3csyh	591	30	tract	tract	NN
cord-270892-ycc3csyh	591	31	.	.	.
cord-270892-ycc3csyh	592	1	The	the	DT
cord-270892-ycc3csyh	592	2	efficacy	efficacy	NN
cord-270892-ycc3csyh	592	3	of	of	IN
cord-270892-ycc3csyh	592	4	Umckaloabo	Umckaloabo	NNP
cord-270892-ycc3csyh	592	5	compared	compare	VBN
cord-270892-ycc3csyh	592	6	with	with	IN
cord-270892-ycc3csyh	592	7	placebo	placebo	NN
cord-270892-ycc3csyh	592	8	has	have	VBZ
cord-270892-ycc3csyh	592	9	been	be	VBN
cord-270892-ycc3csyh	592	10	evaluated	evaluate	VBN
cord-270892-ycc3csyh	592	11	in	in	IN
cord-270892-ycc3csyh	592	12	103	103	CD
cord-270892-ycc3csyh	592	13	adults	adult	NNS
cord-270892-ycc3csyh	592	14	suffering	suffer	VBG
cord-270892-ycc3csyh	592	15	from	from	IN
cord-270892-ycc3csyh	592	16	common	common	JJ
cord-270892-ycc3csyh	592	17	cold	cold	NN
cord-270892-ycc3csyh	592	18	by	by	IN
cord-270892-ycc3csyh	592	19	Lizogub	Lizogub	NNP
cord-270892-ycc3csyh	592	20	et	et	NNP
cord-270892-ycc3csyh	592	21	al	al	NNP
cord-270892-ycc3csyh	592	22	.	.	.
cord-270892-ycc3csyh	593	1	303	303	CD
cord-270892-ycc3csyh	594	1	The	the	DT
cord-270892-ycc3csyh	594	2	applied	applied	JJ
cord-270892-ycc3csyh	594	3	herbal	herbal	JJ
cord-270892-ycc3csyh	594	4	preparation	preparation	NN
cord-270892-ycc3csyh	594	5	was	be	VBD
cord-270892-ycc3csyh	594	6	well	well	RB
cord-270892-ycc3csyh	594	7	tolerated	tolerate	VBN
cord-270892-ycc3csyh	594	8	by	by	IN
cord-270892-ycc3csyh	594	9	the	the	DT
cord-270892-ycc3csyh	594	10	patients	patient	NNS
cord-270892-ycc3csyh	594	11	.	.	.
cord-270892-ycc3csyh	595	1	The	the	DT
cord-270892-ycc3csyh	595	2	study	study	NN
cord-270892-ycc3csyh	595	3	demonstrated	demonstrate	VBD
cord-270892-ycc3csyh	595	4	only	only	RB
cord-270892-ycc3csyh	595	5	a	a	DT
cord-270892-ycc3csyh	595	6	weak	weak	JJ
cord-270892-ycc3csyh	595	7	efficacy	efficacy	NN
cord-270892-ycc3csyh	595	8	of	of	IN
cord-270892-ycc3csyh	595	9	Umckaloabo	Umckaloabo	NNP
cord-270892-ycc3csyh	595	10	compared	compare	VBN
cord-270892-ycc3csyh	595	11	to	to	IN
cord-270892-ycc3csyh	595	12	placebo	placebo	NN
cord-270892-ycc3csyh	595	13	after	after	IN
cord-270892-ycc3csyh	595	14	5	5	CD
cord-270892-ycc3csyh	595	15	days	day	NNS
cord-270892-ycc3csyh	595	16	.	.	.
cord-270892-ycc3csyh	596	1	After	after	IN
cord-270892-ycc3csyh	596	2	10	10	CD
cord-270892-ycc3csyh	596	3	days	day	NNS
cord-270892-ycc3csyh	596	4	,	,	,
cord-270892-ycc3csyh	596	5	however	however	RB
cord-270892-ycc3csyh	596	6	,	,	,
cord-270892-ycc3csyh	596	7	the	the	DT
cord-270892-ycc3csyh	596	8	P.	P.	NNP
cord-270892-ycc3csyh	596	9	sidoides	sidoide	NNS
cord-270892-ycc3csyh	596	10	extract	extract	NN
cord-270892-ycc3csyh	596	11	significantly	significantly	RB
cord-270892-ycc3csyh	596	12	reduced	reduce	VBD
cord-270892-ycc3csyh	596	13	the	the	DT
cord-270892-ycc3csyh	596	14	severity	severity	NN
cord-270892-ycc3csyh	596	15	of	of	IN
cord-270892-ycc3csyh	596	16	symptoms	symptom	NNS
cord-270892-ycc3csyh	596	17	and	and	CC
cord-270892-ycc3csyh	596	18	shortened	shorten	VBD
cord-270892-ycc3csyh	596	19	the	the	DT
cord-270892-ycc3csyh	596	20	duration	duration	NN
cord-270892-ycc3csyh	596	21	of	of	IN
cord-270892-ycc3csyh	596	22	the	the	DT
cord-270892-ycc3csyh	596	23	common	common	JJ
cord-270892-ycc3csyh	596	24	cold	cold	NN
cord-270892-ycc3csyh	596	25	compared	compare	VBN
cord-270892-ycc3csyh	596	26	with	with	IN
cord-270892-ycc3csyh	596	27	placebo	placebo	NN
cord-270892-ycc3csyh	596	28	.	.	.
cord-270892-ycc3csyh	597	1	Just	just	RB
cord-270892-ycc3csyh	597	2	recently	recently	RB
cord-270892-ycc3csyh	597	3	,	,	,
cord-270892-ycc3csyh	597	4	Timmer	Timmer	NNP
cord-270892-ycc3csyh	597	5	et	et	NNP
cord-270892-ycc3csyh	597	6	al	al	NNP
cord-270892-ycc3csyh	597	7	.	.	.
cord-270892-ycc3csyh	598	1	selected	select	VBN
cord-270892-ycc3csyh	598	2	randomized	randomized	JJ
cord-270892-ycc3csyh	598	3	controlled	control	VBN
cord-270892-ycc3csyh	598	4	trials	trial	NNS
cord-270892-ycc3csyh	598	5	examining	examine	VBG
cord-270892-ycc3csyh	598	6	the	the	DT
cord-270892-ycc3csyh	598	7	efficacy	efficacy	NN
cord-270892-ycc3csyh	598	8	of	of	IN
cord-270892-ycc3csyh	598	9	P.	P.	NNP
cord-270892-ycc3csyh	598	10	sidoides	sidoides	NNP
cord-270892-ycc3csyh	598	11	preparations	preparation	NNS
cord-270892-ycc3csyh	598	12	for	for	IN
cord-270892-ycc3csyh	598	13	the	the	DT
cord-270892-ycc3csyh	598	14	treatment	treatment	NN
cord-270892-ycc3csyh	598	15	of	of	IN
cord-270892-ycc3csyh	598	16	various	various	JJ
cord-270892-ycc3csyh	598	17	acute	acute	JJ
cord-270892-ycc3csyh	598	18	respiratory	respiratory	JJ
cord-270892-ycc3csyh	598	19	infections	infection	NNS
cord-270892-ycc3csyh	598	20	and	and	CC
cord-270892-ycc3csyh	598	21	analyzed	analyze	VBD
cord-270892-ycc3csyh	598	22	their	-PRON-	PRP$
cord-270892-ycc3csyh	598	23	efficacy	efficacy	NN
cord-270892-ycc3csyh	598	24	and	and	CC
cord-270892-ycc3csyh	598	25	safety	safety	NN
cord-270892-ycc3csyh	598	26	.	.	.
cord-270892-ycc3csyh	599	1	304	304	CD
cord-270892-ycc3csyh	600	1	The	the	DT
cord-270892-ycc3csyh	600	2	authors	author	NNS
cord-270892-ycc3csyh	600	3	concluded	conclude	VBD
cord-270892-ycc3csyh	600	4	that	that	IN
cord-270892-ycc3csyh	600	5	Umckaloabo	Umckaloabo	NNP
cord-270892-ycc3csyh	600	6	may	may	MD
cord-270892-ycc3csyh	600	7	be	be	VB
cord-270892-ycc3csyh	600	8	effective	effective	JJ
cord-270892-ycc3csyh	600	9	in	in	IN
cord-270892-ycc3csyh	600	10	alleviating	alleviate	VBG
cord-270892-ycc3csyh	600	11	symptoms	symptom	NNS
cord-270892-ycc3csyh	600	12	of	of	IN
cord-270892-ycc3csyh	600	13	acute	acute	JJ
cord-270892-ycc3csyh	600	14	rhino	rhino	NN
cord-270892-ycc3csyh	600	15	-	-	HYPH
cord-270892-ycc3csyh	600	16	sinusitis	sinusitis	NN
cord-270892-ycc3csyh	600	17	and	and	CC
cord-270892-ycc3csyh	600	18	the	the	DT
cord-270892-ycc3csyh	600	19	common	common	JJ
cord-270892-ycc3csyh	600	20	cold	cold	NN
cord-270892-ycc3csyh	600	21	in	in	IN
cord-270892-ycc3csyh	600	22	adults	adult	NNS
cord-270892-ycc3csyh	600	23	.	.	.
cord-270892-ycc3csyh	601	1	It	-PRON-	PRP
cord-270892-ycc3csyh	601	2	may	may	MD
cord-270892-ycc3csyh	601	3	be	be	VB
cord-270892-ycc3csyh	601	4	effective	effective	JJ
cord-270892-ycc3csyh	601	5	in	in	IN
cord-270892-ycc3csyh	601	6	relieving	relieve	VBG
cord-270892-ycc3csyh	601	7	symptoms	symptom	NNS
cord-270892-ycc3csyh	601	8	in	in	IN
cord-270892-ycc3csyh	601	9	acute	acute	JJ
cord-270892-ycc3csyh	601	10	bronchitis	bronchitis	NN
cord-270892-ycc3csyh	601	11	in	in	IN
cord-270892-ycc3csyh	601	12	adults	adult	NNS
cord-270892-ycc3csyh	601	13	and	and	CC
cord-270892-ycc3csyh	601	14	children	child	NNS
cord-270892-ycc3csyh	601	15	,	,	,
cord-270892-ycc3csyh	601	16	and	and	CC
cord-270892-ycc3csyh	601	17	sinusitis	sinusitis	NN
cord-270892-ycc3csyh	601	18	in	in	IN
cord-270892-ycc3csyh	601	19	adults	adult	NNS
cord-270892-ycc3csyh	601	20	.	.	.
cord-270892-ycc3csyh	602	1	Reliable	reliable	JJ
cord-270892-ycc3csyh	602	2	data	datum	NNS
cord-270892-ycc3csyh	602	3	on	on	IN
cord-270892-ycc3csyh	602	4	the	the	DT
cord-270892-ycc3csyh	602	5	treatment	treatment	NN
cord-270892-ycc3csyh	602	6	for	for	IN
cord-270892-ycc3csyh	602	7	other	other	JJ
cord-270892-ycc3csyh	602	8	acute	acute	JJ
cord-270892-ycc3csyh	602	9	respiratory	respiratory	JJ
cord-270892-ycc3csyh	602	10	infections	infection	NNS
cord-270892-ycc3csyh	602	11	however	however	RB
cord-270892-ycc3csyh	602	12	were	be	VBD
cord-270892-ycc3csyh	602	13	not	not	RB
cord-270892-ycc3csyh	602	14	obtained	obtain	VBN
cord-270892-ycc3csyh	602	15	.	.	.
cord-270892-ycc3csyh	603	1	Identification	identification	NN
cord-270892-ycc3csyh	603	2	of	of	IN
cord-270892-ycc3csyh	603	3	the	the	DT
cord-270892-ycc3csyh	603	4	metabolites	metabolite	NNS
cord-270892-ycc3csyh	603	5	from	from	IN
cord-270892-ycc3csyh	603	6	Umckaloabo	Umckaloabo	NNP
cord-270892-ycc3csyh	603	7	revealed	reveal	VBD
cord-270892-ycc3csyh	603	8	a	a	DT
cord-270892-ycc3csyh	603	9	high	high	JJ
cord-270892-ycc3csyh	603	10	number	number	NN
cord-270892-ycc3csyh	603	11	of	of	IN
cord-270892-ycc3csyh	603	12	different	different	JJ
cord-270892-ycc3csyh	603	13	chemical	chemical	NN
cord-270892-ycc3csyh	603	14	classes	class	NNS
cord-270892-ycc3csyh	603	15	,	,	,
cord-270892-ycc3csyh	603	16	such	such	JJ
cord-270892-ycc3csyh	603	17	as	as	IN
cord-270892-ycc3csyh	603	18	phenolic	phenolic	JJ
cord-270892-ycc3csyh	603	19	and	and	CC
cord-270892-ycc3csyh	603	20	cinnamic	cinnamic	JJ
cord-270892-ycc3csyh	603	21	acids	acid	NNS
cord-270892-ycc3csyh	603	22	,	,	,
cord-270892-ycc3csyh	603	23	tannins	tannin	NNS
cord-270892-ycc3csyh	603	24	,	,	,
cord-270892-ycc3csyh	603	25	flavonoids	flavonoid	NNS
cord-270892-ycc3csyh	603	26	,	,	,
cord-270892-ycc3csyh	603	27	and	and	CC
cord-270892-ycc3csyh	603	28	coumarins	coumarin	NNS
cord-270892-ycc3csyh	603	29	.	.	.
cord-270892-ycc3csyh	604	1	Antibacterial	antibacterial	JJ
cord-270892-ycc3csyh	604	2	activities	activity	NNS
cord-270892-ycc3csyh	604	3	of	of	IN
cord-270892-ycc3csyh	604	4	Umckaloabo	Umckaloabo	NNP
cord-270892-ycc3csyh	604	5	against	against	IN
cord-270892-ycc3csyh	604	6	different	different	JJ
cord-270892-ycc3csyh	604	7	pathogens	pathogen	NNS
cord-270892-ycc3csyh	604	8	have	have	VBP
cord-270892-ycc3csyh	604	9	been	be	VBN
cord-270892-ycc3csyh	604	10	reported	report	VBN
cord-270892-ycc3csyh	604	11	.	.	.
cord-270892-ycc3csyh	605	1	Phenols	phenol	NNS
cord-270892-ycc3csyh	605	2	,	,	,
cord-270892-ycc3csyh	605	3	coumarins	coumarin	NNS
cord-270892-ycc3csyh	605	4	,	,	,
cord-270892-ycc3csyh	605	5	and	and	CC
cord-270892-ycc3csyh	605	6	tannins	tannin	NNS
cord-270892-ycc3csyh	605	7	have	have	VBP
cord-270892-ycc3csyh	605	8	been	be	VBN
cord-270892-ycc3csyh	605	9	identified	identify	VBN
cord-270892-ycc3csyh	605	10	to	to	TO
cord-270892-ycc3csyh	605	11	contribute	contribute	VB
cord-270892-ycc3csyh	605	12	with	with	IN
cord-270892-ycc3csyh	605	13	moderate	moderate	JJ
cord-270892-ycc3csyh	605	14	antibacterial	antibacterial	JJ
cord-270892-ycc3csyh	605	15	activities	activity	NNS
cord-270892-ycc3csyh	605	16	,	,	,
cord-270892-ycc3csyh	605	17	however	however	RB
cord-270892-ycc3csyh	605	18	,	,	,
cord-270892-ycc3csyh	605	19	can	can	MD
cord-270892-ycc3csyh	605	20	not	not	RB
cord-270892-ycc3csyh	605	21	explain	explain	VB
cord-270892-ycc3csyh	605	22	the	the	DT
cord-270892-ycc3csyh	605	23	effect	effect	NN
cord-270892-ycc3csyh	605	24	of	of	IN
cord-270892-ycc3csyh	605	25	the	the	DT
cord-270892-ycc3csyh	605	26	whole	whole	JJ
cord-270892-ycc3csyh	605	27	extract	extract	NN
cord-270892-ycc3csyh	605	28	(	(	-LRB-
cord-270892-ycc3csyh	605	29	reviewed	review	VBN
cord-270892-ycc3csyh	605	30	by	by	IN
cord-270892-ycc3csyh	605	31	Kolodziej	Kolodziej	NNP
cord-270892-ycc3csyh	605	32	305	305	CD
cord-270892-ycc3csyh	605	33	,	,	,
cord-270892-ycc3csyh	605	34	306	306	CD
cord-270892-ycc3csyh	605	35	)	)	-RRB-
cord-270892-ycc3csyh	605	36	.	.	.
cord-270892-ycc3csyh	606	1	Additionally	additionally	RB
cord-270892-ycc3csyh	606	2	,	,	,
cord-270892-ycc3csyh	606	3	P.	P.	NNP
cord-270892-ycc3csyh	606	4	sidoides	sidoide	NNS
cord-270892-ycc3csyh	606	5	extracts	extract	NNS
cord-270892-ycc3csyh	606	6	have	have	VBP
cord-270892-ycc3csyh	606	7	been	be	VBN
cord-270892-ycc3csyh	606	8	reported	report	VBN
cord-270892-ycc3csyh	606	9	to	to	TO
cord-270892-ycc3csyh	606	10	significantly	significantly	RB
cord-270892-ycc3csyh	606	11	activate	activate	VB
cord-270892-ycc3csyh	606	12	the	the	DT
cord-270892-ycc3csyh	606	13	nonspecific	nonspecific	JJ
cord-270892-ycc3csyh	606	14	immune	immune	JJ
cord-270892-ycc3csyh	606	15	system	system	NN
cord-270892-ycc3csyh	606	16	by	by	IN
cord-270892-ycc3csyh	606	17	induction	induction	NN
cord-270892-ycc3csyh	606	18	of	of	IN
cord-270892-ycc3csyh	606	19	TNF	TNF	NNP
cord-270892-ycc3csyh	606	20	and	and	CC
cord-270892-ycc3csyh	606	21	NO	no	NN
cord-270892-ycc3csyh	606	22	-	-	HYPH
cord-270892-ycc3csyh	606	23	release	release	NN
cord-270892-ycc3csyh	606	24	,	,	,
cord-270892-ycc3csyh	606	25	and	and	CC
cord-270892-ycc3csyh	606	26	IFN	IFN	NNP
cord-270892-ycc3csyh	606	27	-	-	HYPH
cord-270892-ycc3csyh	606	28	like	like	JJ
cord-270892-ycc3csyh	606	29	activities	activity	NNS
cord-270892-ycc3csyh	606	30	.	.	.
cord-270892-ycc3csyh	607	1	305	305	CD
cord-270892-ycc3csyh	608	1	These	these	DT
cord-270892-ycc3csyh	608	2	effects	effect	NNS
cord-270892-ycc3csyh	608	3	are	be	VBP
cord-270892-ycc3csyh	608	4	assumed	assume	VBN
cord-270892-ycc3csyh	608	5	to	to	TO
cord-270892-ycc3csyh	608	6	contribute	contribute	VB
cord-270892-ycc3csyh	608	7	to	to	IN
cord-270892-ycc3csyh	608	8	the	the	DT
cord-270892-ycc3csyh	608	9	controversially	controversially	RB
cord-270892-ycc3csyh	608	10	discussed	discuss	VBN
cord-270892-ycc3csyh	608	11	potential	potential	NN
cord-270892-ycc3csyh	608	12	of	of	IN
cord-270892-ycc3csyh	608	13	P.	P.	NNP
cord-270892-ycc3csyh	608	14	sidoides	sidoide	NNS
cord-270892-ycc3csyh	608	15	extract	extract	NN
cord-270892-ycc3csyh	608	16	for	for	IN
cord-270892-ycc3csyh	608	17	the	the	DT
cord-270892-ycc3csyh	608	18	treatment	treatment	NN
cord-270892-ycc3csyh	608	19	of	of	IN
cord-270892-ycc3csyh	608	20	upper	upper	JJ
cord-270892-ycc3csyh	608	21	respiratory	respiratory	JJ
cord-270892-ycc3csyh	608	22	tract	tract	NN
cord-270892-ycc3csyh	608	23	infections	infection	NNS
cord-270892-ycc3csyh	608	24	.	.	.
cord-270892-ycc3csyh	609	1	Only	only	RB
cord-270892-ycc3csyh	609	2	one	one	CD
cord-270892-ycc3csyh	609	3	study	study	NN
cord-270892-ycc3csyh	609	4	reports	report	VBZ
cord-270892-ycc3csyh	609	5	a	a	DT
cord-270892-ycc3csyh	609	6	direct	direct	JJ
cord-270892-ycc3csyh	609	7	antiviral	antiviral	JJ
cord-270892-ycc3csyh	609	8	effect	effect	NN
cord-270892-ycc3csyh	609	9	,	,	,
cord-270892-ycc3csyh	609	10	i.e.	i.e.	FW
cord-270892-ycc3csyh	609	11	a	a	DT
cord-270892-ycc3csyh	609	12	clear	clear	JJ
cord-270892-ycc3csyh	609	13	dose	dose	NN
cord-270892-ycc3csyh	609	14	-	-	HYPH
cord-270892-ycc3csyh	609	15	dependent	dependent	JJ
cord-270892-ycc3csyh	609	16	anti	anti	JJ
cord-270892-ycc3csyh	609	17	-	-	JJ
cord-270892-ycc3csyh	609	18	herpes	herpes	JJ
cord-270892-ycc3csyh	609	19	simplex	simplex	NN
cord-270892-ycc3csyh	609	20	virus	virus	NN
cord-270892-ycc3csyh	609	21	acitivity	acitivity	NN
cord-270892-ycc3csyh	609	22	for	for	IN
cord-270892-ycc3csyh	609	23	the	the	DT
cord-270892-ycc3csyh	609	24	aqueous	aqueous	JJ
cord-270892-ycc3csyh	609	25	root	root	NN
cord-270892-ycc3csyh	609	26	extract	extract	NN
cord-270892-ycc3csyh	609	27	of	of	IN
cord-270892-ycc3csyh	609	28	P.	P.	NNP
cord-270892-ycc3csyh	609	29	sidoides	sidoide	NNS
cord-270892-ycc3csyh	609	30	.	.	.
cord-270892-ycc3csyh	610	1	307	307	CD
cord-270892-ycc3csyh	611	1	Further	further	JJ
cord-270892-ycc3csyh	611	2	pharmacological	pharmacological	JJ
cord-270892-ycc3csyh	611	3	studies	study	NNS
cord-270892-ycc3csyh	611	4	are	be	VBP
cord-270892-ycc3csyh	611	5	needed	need	VBN
cord-270892-ycc3csyh	611	6	to	to	TO
cord-270892-ycc3csyh	611	7	elucidate	elucidate	VB
cord-270892-ycc3csyh	611	8	potential	potential	JJ
cord-270892-ycc3csyh	611	9	direct	direct	JJ
cord-270892-ycc3csyh	611	10	anti	anti	JJ
cord-270892-ycc3csyh	611	11	-	-	JJ
cord-270892-ycc3csyh	611	12	HRV	HRV	NNP
cord-270892-ycc3csyh	611	13	properties	property	NNS
cord-270892-ycc3csyh	611	14	of	of	IN
cord-270892-ycc3csyh	611	15	Umckaloaba	Umckaloaba	NNP
cord-270892-ycc3csyh	611	16	and	and	CC
cord-270892-ycc3csyh	611	17	its	-PRON-	PRP$
cord-270892-ycc3csyh	611	18	constituents	constituent	NNS
cord-270892-ycc3csyh	611	19	.	.	.
cord-270892-ycc3csyh	612	1	Carrageenan	carrageenan	NN
cord-270892-ycc3csyh	612	2	,	,	,
cord-270892-ycc3csyh	612	3	a	a	DT
cord-270892-ycc3csyh	612	4	mixture	mixture	NN
cord-270892-ycc3csyh	612	5	of	of	IN
cord-270892-ycc3csyh	612	6	different	different	JJ
cord-270892-ycc3csyh	612	7	polysaccharides	polysaccharide	NNS
cord-270892-ycc3csyh	612	8	,	,	,
cord-270892-ycc3csyh	612	9	which	which	WDT
cord-270892-ycc3csyh	612	10	is	be	VBZ
cord-270892-ycc3csyh	612	11	mainly	mainly	RB
cord-270892-ycc3csyh	612	12	extracted	extract	VBN
cord-270892-ycc3csyh	612	13	from	from	IN
cord-270892-ycc3csyh	612	14	red	red	JJ
cord-270892-ycc3csyh	612	15	seaweeds	seaweed	NNS
cord-270892-ycc3csyh	612	16	,	,	,
cord-270892-ycc3csyh	612	17	has	have	VBZ
cord-270892-ycc3csyh	612	18	been	be	VBN
cord-270892-ycc3csyh	612	19	extensively	extensively	RB
cord-270892-ycc3csyh	612	20	used	use	VBN
cord-270892-ycc3csyh	612	21	in	in	IN
cord-270892-ycc3csyh	612	22	food	food	NN
cord-270892-ycc3csyh	612	23	,	,	,
cord-270892-ycc3csyh	612	24	cosmetic	cosmetic	JJ
cord-270892-ycc3csyh	612	25	and	and	CC
cord-270892-ycc3csyh	612	26	pharmaceutical	pharmaceutical	JJ
cord-270892-ycc3csyh	612	27	industry	industry	NN
cord-270892-ycc3csyh	612	28	as	as	IN
cord-270892-ycc3csyh	612	29	a	a	DT
cord-270892-ycc3csyh	612	30	thickener	thickener	NN
cord-270892-ycc3csyh	612	31	and	and	CC
cord-270892-ycc3csyh	612	32	gelling	gel	VBG
cord-270892-ycc3csyh	612	33	agent	agent	NN
cord-270892-ycc3csyh	612	34	.	.	.
cord-270892-ycc3csyh	613	1	It	-PRON-	PRP
cord-270892-ycc3csyh	613	2	has	have	VBZ
cord-270892-ycc3csyh	613	3	previously	previously	RB
cord-270892-ycc3csyh	613	4	shown	show	VBN
cord-270892-ycc3csyh	613	5	an	an	DT
cord-270892-ycc3csyh	613	6	antiviral	antiviral	JJ
cord-270892-ycc3csyh	613	7	efficacy	efficacy	NN
cord-270892-ycc3csyh	613	8	against	against	IN
cord-270892-ycc3csyh	613	9	several	several	JJ
cord-270892-ycc3csyh	613	10	viruses	virus	NNS
cord-270892-ycc3csyh	613	11	.	.	.
cord-270892-ycc3csyh	614	1	308	308	CD
cord-270892-ycc3csyh	614	2	,	,	,
cord-270892-ycc3csyh	614	3	309	309	CD
cord-270892-ycc3csyh	615	1	In	in	IN
cord-270892-ycc3csyh	615	2	a	a	DT
cord-270892-ycc3csyh	615	3	recently	recently	RB
cord-270892-ycc3csyh	615	4	published	publish	VBN
cord-270892-ycc3csyh	615	5	study	study	NN
cord-270892-ycc3csyh	615	6	,	,	,
cord-270892-ycc3csyh	615	7	Lambda-	Lambda-	NNP
cord-270892-ycc3csyh	615	8	,	,	,
cord-270892-ycc3csyh	615	9	Kappa	Kappa	NNP
cord-270892-ycc3csyh	615	10	,	,	,
cord-270892-ycc3csyh	615	11	and	and	CC
cord-270892-ycc3csyh	615	12	Iota	Iota	NNP
cord-270892-ycc3csyh	615	13	-	-	HYPH
cord-270892-ycc3csyh	615	14	carrageenan	carrageenan	NN
cord-270892-ycc3csyh	615	15	were	be	VBD
cord-270892-ycc3csyh	615	16	investigated	investigate	VBN
cord-270892-ycc3csyh	615	17	for	for	IN
cord-270892-ycc3csyh	615	18	their	-PRON-	PRP$
cord-270892-ycc3csyh	615	19	anti	anti	JJ
cord-270892-ycc3csyh	615	20	-	-	JJ
cord-270892-ycc3csyh	615	21	HRV	HRV	NNP
cord-270892-ycc3csyh	615	22	inhibiting	inhibit	VBG
cord-270892-ycc3csyh	615	23	potential	potential	NN
cord-270892-ycc3csyh	615	24	.	.	.
cord-270892-ycc3csyh	616	1	At	at	IN
cord-270892-ycc3csyh	616	2	a	a	DT
cord-270892-ycc3csyh	616	3	concentration	concentration	NN
cord-270892-ycc3csyh	616	4	of	of	IN
cord-270892-ycc3csyh	616	5	200	200	CD
cord-270892-ycc3csyh	616	6	mg	mg	NNP
cord-270892-ycc3csyh	616	7	/	/	SYM
cord-270892-ycc3csyh	616	8	mL	mL	NNP
cord-270892-ycc3csyh	616	9	Iotacarragenan	Iotacarragenan	NNP
cord-270892-ycc3csyh	616	10	,	,	,
cord-270892-ycc3csyh	616	11	a	a	DT
cord-270892-ycc3csyh	616	12	sulphated	sulphate	VBN
cord-270892-ycc3csyh	616	13	polysaccharide	polysaccharide	NN
cord-270892-ycc3csyh	616	14	,	,	,
cord-270892-ycc3csyh	616	15	was	be	VBD
cord-270892-ycc3csyh	616	16	able	able	JJ
cord-270892-ycc3csyh	616	17	to	to	TO
cord-270892-ycc3csyh	616	18	fully	fully	RB
cord-270892-ycc3csyh	616	19	inhibit	inhibit	VB
cord-270892-ycc3csyh	616	20	virus	virus	NN
cord-270892-ycc3csyh	616	21	-	-	HYPH
cord-270892-ycc3csyh	616	22	induced	induce	VBN
cord-270892-ycc3csyh	616	23	cell	cell	NN
cord-270892-ycc3csyh	616	24	death	death	NN
cord-270892-ycc3csyh	616	25	in	in	IN
cord-270892-ycc3csyh	617	1	HRV-2	hrv-2	IN
cord-270892-ycc3csyh	617	2	infected	infected	JJ
cord-270892-ycc3csyh	617	3	HeLa	HeLa	NNP
cord-270892-ycc3csyh	617	4	cells	cell	NNS
cord-270892-ycc3csyh	617	5	.	.	.
cord-270892-ycc3csyh	618	1	310	310	CD
cord-270892-ycc3csyh	618	2	Based	base	VBN
cord-270892-ycc3csyh	618	3	on	on	IN
cord-270892-ycc3csyh	618	4	their	-PRON-	PRP$
cord-270892-ycc3csyh	618	5	studies	study	NNS
cord-270892-ycc3csyh	618	6	,	,	,
cord-270892-ycc3csyh	618	7	Grassauer	Grassauer	NNP
cord-270892-ycc3csyh	618	8	et	et	NNP
cord-270892-ycc3csyh	618	9	al	al	NNP
cord-270892-ycc3csyh	618	10	.	.	NNP
cord-270892-ycc3csyh	618	11	concluded	conclude	VBD
cord-270892-ycc3csyh	618	12	that	that	IN
cord-270892-ycc3csyh	618	13	Iotacarrageenan	Iotacarrageenan	NNP
cord-270892-ycc3csyh	618	14	is	be	VBZ
cord-270892-ycc3csyh	618	15	effective	effective	JJ
cord-270892-ycc3csyh	618	16	against	against	IN
cord-270892-ycc3csyh	618	17	different	different	JJ
cord-270892-ycc3csyh	618	18	HRV	HRV	NNP
cord-270892-ycc3csyh	618	19	-	-	HYPH
cord-270892-ycc3csyh	618	20	serotypes	serotype	NNS
cord-270892-ycc3csyh	618	21	on	on	IN
cord-270892-ycc3csyh	618	22	primary	primary	JJ
cord-270892-ycc3csyh	618	23	human	human	JJ
cord-270892-ycc3csyh	618	24	epithelial	epithelial	JJ
cord-270892-ycc3csyh	618	25	cells	cell	NNS
cord-270892-ycc3csyh	618	26	.	.	.
cord-270892-ycc3csyh	619	1	It	-PRON-	PRP
cord-270892-ycc3csyh	619	2	is	be	VBZ
cord-270892-ycc3csyh	619	3	hypothesized	hypothesize	VBN
cord-270892-ycc3csyh	619	4	by	by	IN
cord-270892-ycc3csyh	619	5	the	the	DT
cord-270892-ycc3csyh	619	6	authors	author	NNS
cord-270892-ycc3csyh	619	7	that	that	WDT
cord-270892-ycc3csyh	619	8	Iota	Iota	NNP
cord-270892-ycc3csyh	619	9	-	-	HYPH
cord-270892-ycc3csyh	619	10	carrageenan	carrageenan	NNP
cord-270892-ycc3csyh	619	11	might	may	MD
cord-270892-ycc3csyh	619	12	create	create	VB
cord-270892-ycc3csyh	619	13	a	a	DT
cord-270892-ycc3csyh	619	14	hostile	hostile	JJ
cord-270892-ycc3csyh	619	15	environment	environment	NN
cord-270892-ycc3csyh	619	16	for	for	IN
cord-270892-ycc3csyh	619	17	HRV	HRV	NNP
cord-270892-ycc3csyh	619	18	and	and	CC
cord-270892-ycc3csyh	619	19	thereby	thereby	RB
cord-270892-ycc3csyh	619	20	block	block	VB
cord-270892-ycc3csyh	619	21	viral	viral	JJ
cord-270892-ycc3csyh	619	22	entry	entry	NN
cord-270892-ycc3csyh	619	23	and	and	CC
cord-270892-ycc3csyh	619	24	replication	replication	NN
cord-270892-ycc3csyh	619	25	.	.	.
cord-270892-ycc3csyh	620	1	Because	because	IN
cord-270892-ycc3csyh	620	2	of	of	IN
cord-270892-ycc3csyh	620	3	its	-PRON-	PRP$
cord-270892-ycc3csyh	620	4	safe	safe	JJ
cord-270892-ycc3csyh	620	5	application	application	NN
cord-270892-ycc3csyh	620	6	and	and	CC
cord-270892-ycc3csyh	620	7	proved	prove	VBN
cord-270892-ycc3csyh	620	8	in	in	IN
cord-270892-ycc3csyh	620	9	vitro	vitro	FW
cord-270892-ycc3csyh	620	10	efficacy	efficacy	NN
cord-270892-ycc3csyh	620	11	,	,	,
cord-270892-ycc3csyh	620	12	Iota	Iota	NNP
cord-270892-ycc3csyh	620	13	-	-	HYPH
cord-270892-ycc3csyh	620	14	carrageenan	carrageenan	NNP
cord-270892-ycc3csyh	620	15	deserves	deserve	VBZ
cord-270892-ycc3csyh	620	16	consideration	consideration	NN
cord-270892-ycc3csyh	620	17	as	as	IN
cord-270892-ycc3csyh	620	18	a	a	DT
cord-270892-ycc3csyh	620	19	candidate	candidate	NN
cord-270892-ycc3csyh	620	20	for	for	IN
cord-270892-ycc3csyh	620	21	clinical	clinical	JJ
cord-270892-ycc3csyh	620	22	trials	trial	NNS
cord-270892-ycc3csyh	620	23	for	for	IN
cord-270892-ycc3csyh	620	24	prevention	prevention	NN
cord-270892-ycc3csyh	620	25	and	and	CC
cord-270892-ycc3csyh	620	26	therapy	therapy	NN
cord-270892-ycc3csyh	620	27	of	of	IN
cord-270892-ycc3csyh	620	28	HRV	HRV	NNP
cord-270892-ycc3csyh	620	29	-	-	HYPH
cord-270892-ycc3csyh	620	30	induced	induce	VBN
cord-270892-ycc3csyh	620	31	common	common	JJ
cord-270892-ycc3csyh	620	32	cold	cold	NN
cord-270892-ycc3csyh	620	33	.	.	.
cord-270892-ycc3csyh	621	1	The	the	DT
cord-270892-ycc3csyh	621	2	level	level	NN
cord-270892-ycc3csyh	621	3	of	of	IN
cord-270892-ycc3csyh	621	4	knowledge	knowledge	NN
cord-270892-ycc3csyh	621	5	on	on	IN
cord-270892-ycc3csyh	621	6	the	the	DT
cord-270892-ycc3csyh	621	7	impact	impact	NN
cord-270892-ycc3csyh	621	8	of	of	IN
cord-270892-ycc3csyh	621	9	the	the	DT
cord-270892-ycc3csyh	621	10	six	six	CD
cord-270892-ycc3csyh	621	11	botanicals	botanical	NNS
cord-270892-ycc3csyh	621	12	on	on	IN
cord-270892-ycc3csyh	621	13	HRV	HRV	NNP
cord-270892-ycc3csyh	621	14	-	-	HYPH
cord-270892-ycc3csyh	621	15	infection	infection	NN
cord-270892-ycc3csyh	621	16	discussed	discuss	VBN
cord-270892-ycc3csyh	621	17	above	above	RB
cord-270892-ycc3csyh	621	18	is	be	VBZ
cord-270892-ycc3csyh	621	19	different	different	JJ
cord-270892-ycc3csyh	621	20	and	and	CC
cord-270892-ycc3csyh	621	21	heterogeneous	heterogeneous	JJ
cord-270892-ycc3csyh	621	22	.	.	.
cord-270892-ycc3csyh	622	1	The	the	DT
cord-270892-ycc3csyh	622	2	best	well	RBS
cord-270892-ycc3csyh	622	3	studied	study	VBN
cord-270892-ycc3csyh	622	4	herbal	herbal	JJ
cord-270892-ycc3csyh	622	5	remedy	remedy	NN
cord-270892-ycc3csyh	622	6	associated	associate	VBN
cord-270892-ycc3csyh	622	7	with	with	IN
cord-270892-ycc3csyh	622	8	common	common	JJ
cord-270892-ycc3csyh	622	9	cold	cold	NN
cord-270892-ycc3csyh	622	10	,	,	,
cord-270892-ycc3csyh	622	11	i.e.	i.e.	FW
cord-270892-ycc3csyh	622	12	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	622	13	,	,	,
cord-270892-ycc3csyh	622	14	showcases	showcase	VBZ
cord-270892-ycc3csyh	622	15	the	the	DT
cord-270892-ycc3csyh	622	16	innate	innate	JJ
cord-270892-ycc3csyh	622	17	problem	problem	NN
cord-270892-ycc3csyh	622	18	connected	connect	VBN
cord-270892-ycc3csyh	622	19	with	with	IN
cord-270892-ycc3csyh	622	20	multi	multi	JJ
cord-270892-ycc3csyh	622	21	-	-	JJ
cord-270892-ycc3csyh	622	22	component	component	NN
cord-270892-ycc3csyh	622	23	mixtures	mixture	NNS
cord-270892-ycc3csyh	622	24	:	:	:
cord-270892-ycc3csyh	622	25	starting	start	VBG
cord-270892-ycc3csyh	622	26	from	from	IN
cord-270892-ycc3csyh	622	27	the	the	DT
cord-270892-ycc3csyh	622	28	late	late	JJ
cord-270892-ycc3csyh	622	29	nineties	ninety	NNS
cord-270892-ycc3csyh	622	30	till	till	IN
cord-270892-ycc3csyh	622	31	June	June	NNP
cord-270892-ycc3csyh	622	32	2009	2009	CD
cord-270892-ycc3csyh	623	1	some	some	DT
cord-270892-ycc3csyh	623	2	100	100	CD
cord-270892-ycc3csyh	623	3	original	original	JJ
cord-270892-ycc3csyh	623	4	articles	article	NNS
cord-270892-ycc3csyh	623	5	have	have	VBP
cord-270892-ycc3csyh	623	6	been	be	VBN
cord-270892-ycc3csyh	623	7	published	publish	VBN
cord-270892-ycc3csyh	623	8	to	to	IN
cord-270892-ycc3csyh	623	9	this	this	DT
cord-270892-ycc3csyh	623	10	topic	topic	NN
cord-270892-ycc3csyh	623	11	and	and	CC
cord-270892-ycc3csyh	623	12	tried	try	VBD
cord-270892-ycc3csyh	623	13	to	to	TO
cord-270892-ycc3csyh	623	14	elucidate	elucidate	VB
cord-270892-ycc3csyh	623	15	questions	question	NNS
cord-270892-ycc3csyh	623	16	concerning	concern	VBG
cord-270892-ycc3csyh	623	17	efficacy	efficacy	NN
cord-270892-ycc3csyh	623	18	,	,	,
cord-270892-ycc3csyh	623	19	molecular	molecular	JJ
cord-270892-ycc3csyh	623	20	mechanism	mechanism	NN
cord-270892-ycc3csyh	623	21	,	,	,
cord-270892-ycc3csyh	623	22	and	and	CC
cord-270892-ycc3csyh	623	23	bioactive	bioactive	JJ
cord-270892-ycc3csyh	623	24	ingredients	ingredient	NNS
cord-270892-ycc3csyh	623	25	of	of	IN
cord-270892-ycc3csyh	623	26	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	623	27	.	.	.
cord-270892-ycc3csyh	624	1	Although	although	IN
cord-270892-ycc3csyh	624	2	some	some	DT
cord-270892-ycc3csyh	624	3	evidence	evidence	NN
cord-270892-ycc3csyh	624	4	is	be	VBZ
cord-270892-ycc3csyh	624	5	provided	provide	VBN
cord-270892-ycc3csyh	624	6	for	for	IN
cord-270892-ycc3csyh	624	7	the	the	DT
cord-270892-ycc3csyh	624	8	effects	effect	NNS
cord-270892-ycc3csyh	624	9	of	of	IN
cord-270892-ycc3csyh	624	10	extracts	extract	NNS
cord-270892-ycc3csyh	624	11	,	,	,
cord-270892-ycc3csyh	624	12	chemical	chemical	NN
cord-270892-ycc3csyh	624	13	classes	class	NNS
cord-270892-ycc3csyh	624	14	as	as	RB
cord-270892-ycc3csyh	624	15	well	well	RB
cord-270892-ycc3csyh	624	16	as	as	IN
cord-270892-ycc3csyh	624	17	well	well	RB
cord-270892-ycc3csyh	624	18	-	-	HYPH
cord-270892-ycc3csyh	624	19	defined	define	VBN
cord-270892-ycc3csyh	624	20	constituents	constituent	NNS
cord-270892-ycc3csyh	624	21	on	on	IN
cord-270892-ycc3csyh	624	22	specific	specific	JJ
cord-270892-ycc3csyh	624	23	targets	target	NNS
cord-270892-ycc3csyh	624	24	and	and	CC
cord-270892-ycc3csyh	624	25	pathways	pathway	NNS
cord-270892-ycc3csyh	624	26	,	,	,
cord-270892-ycc3csyh	624	27	the	the	DT
cord-270892-ycc3csyh	624	28	findings	finding	NNS
cord-270892-ycc3csyh	624	29	can	can	MD
cord-270892-ycc3csyh	624	30	not	not	RB
cord-270892-ycc3csyh	624	31	be	be	VB
cord-270892-ycc3csyh	624	32	deduced	deduce	VBN
cord-270892-ycc3csyh	624	33	to	to	IN
cord-270892-ycc3csyh	624	34	a	a	DT
cord-270892-ycc3csyh	624	35	common	common	JJ
cord-270892-ycc3csyh	624	36	denominator	denominator	NN
cord-270892-ycc3csyh	624	37	.	.	.
cord-270892-ycc3csyh	625	1	Further	further	RB
cord-270892-ycc3csyh	625	2	,	,	,
cord-270892-ycc3csyh	625	3	results	result	NNS
cord-270892-ycc3csyh	625	4	from	from	IN
cord-270892-ycc3csyh	625	5	clinical	clinical	JJ
cord-270892-ycc3csyh	625	6	trials	trial	NNS
cord-270892-ycc3csyh	625	7	often	often	RB
cord-270892-ycc3csyh	625	8	suffer	suffer	VBP
cord-270892-ycc3csyh	625	9	from	from	IN
cord-270892-ycc3csyh	625	10	lack	lack	NN
cord-270892-ycc3csyh	625	11	of	of	IN
cord-270892-ycc3csyh	625	12	comparability	comparability	NN
cord-270892-ycc3csyh	625	13	,	,	,
cord-270892-ycc3csyh	625	14	because	because	IN
cord-270892-ycc3csyh	625	15	of	of	IN
cord-270892-ycc3csyh	625	16	using	use	VBG
cord-270892-ycc3csyh	625	17	different	different	JJ
cord-270892-ycc3csyh	625	18	study	study	NN
cord-270892-ycc3csyh	625	19	designs	design	NNS
cord-270892-ycc3csyh	625	20	,	,	,
cord-270892-ycc3csyh	625	21	outcome	outcome	NN
cord-270892-ycc3csyh	625	22	measures	measure	NNS
cord-270892-ycc3csyh	625	23	,	,	,
cord-270892-ycc3csyh	625	24	and	and	CC
cord-270892-ycc3csyh	625	25	overall	overall	RB
cord-270892-ycc3csyh	625	26	the	the	DT
cord-270892-ycc3csyh	625	27	application	application	NN
cord-270892-ycc3csyh	625	28	of	of	IN
cord-270892-ycc3csyh	625	29	different	different	JJ
cord-270892-ycc3csyh	625	30	preparations	preparation	NNS
cord-270892-ycc3csyh	625	31	.	.	.
cord-270892-ycc3csyh	626	1	279	279	CD
cord-270892-ycc3csyh	627	1	A	a	DT
cord-270892-ycc3csyh	627	2	proper	proper	JJ
cord-270892-ycc3csyh	627	3	quality	quality	NN
cord-270892-ycc3csyh	627	4	analysis	analysis	NN
cord-270892-ycc3csyh	627	5	and	and	CC
cord-270892-ycc3csyh	627	6	characterization	characterization	NN
cord-270892-ycc3csyh	627	7	of	of	IN
cord-270892-ycc3csyh	627	8	the	the	DT
cord-270892-ycc3csyh	627	9	preparation	preparation	NN
cord-270892-ycc3csyh	627	10	under	under	IN
cord-270892-ycc3csyh	627	11	investigation	investigation	NN
cord-270892-ycc3csyh	627	12	is	be	VBZ
cord-270892-ycc3csyh	627	13	mandatory	mandatory	JJ
cord-270892-ycc3csyh	627	14	and	and	CC
cord-270892-ycc3csyh	627	15	should	should	MD
cord-270892-ycc3csyh	627	16	follow	follow	VB
cord-270892-ycc3csyh	627	17	the	the	DT
cord-270892-ycc3csyh	627	18	recommendations	recommendation	NNS
cord-270892-ycc3csyh	627	19	and	and	CC
cord-270892-ycc3csyh	627	20	guidelines	guideline	NNS
cord-270892-ycc3csyh	627	21	for	for	IN
cord-270892-ycc3csyh	627	22	reporting	report	VBG
cord-270892-ycc3csyh	627	23	clinical	clinical	JJ
cord-270892-ycc3csyh	627	24	trials	trial	NNS
cord-270892-ycc3csyh	627	25	for	for	IN
cord-270892-ycc3csyh	627	26	herbal	herbal	JJ
cord-270892-ycc3csyh	627	27	medicine	medicine	NN
cord-270892-ycc3csyh	627	28	.	.	.
cord-270892-ycc3csyh	628	1	311	311	CD
cord-270892-ycc3csyh	629	1	As	as	IN
cord-270892-ycc3csyh	629	2	underlined	underline	VBN
cord-270892-ycc3csyh	629	3	before	before	RB
cord-270892-ycc3csyh	629	4	(	(	-LRB-
cord-270892-ycc3csyh	629	5	Sections	section	NNS
cord-270892-ycc3csyh	629	6	5.1	5.1	CD
cord-270892-ycc3csyh	629	7	.	.	.
cord-270892-ycc3csyh	629	8	and	and	CC
cord-270892-ycc3csyh	629	9	5.2	5.2	CD
cord-270892-ycc3csyh	629	10	.	.	.
cord-270892-ycc3csyh	629	11	)	)	-RRB-
cord-270892-ycc3csyh	629	12	,	,	,
cord-270892-ycc3csyh	629	13	the	the	DT
cord-270892-ycc3csyh	629	14	chemical	chemical	NN
cord-270892-ycc3csyh	629	15	complexity	complexity	NN
cord-270892-ycc3csyh	629	16	of	of	IN
cord-270892-ycc3csyh	629	17	a	a	DT
cord-270892-ycc3csyh	629	18	natural	natural	JJ
cord-270892-ycc3csyh	629	19	preparation	preparation	NN
cord-270892-ycc3csyh	629	20	might	may	MD
cord-270892-ycc3csyh	629	21	be	be	VB
cord-270892-ycc3csyh	629	22	beneficial	beneficial	JJ
cord-270892-ycc3csyh	629	23	in	in	IN
cord-270892-ycc3csyh	629	24	terms	term	NNS
cord-270892-ycc3csyh	629	25	of	of	IN
cord-270892-ycc3csyh	629	26	synergistic	synergistic	JJ
cord-270892-ycc3csyh	629	27	,	,	,
cord-270892-ycc3csyh	629	28	additive	additive	NN
cord-270892-ycc3csyh	629	29	,	,	,
cord-270892-ycc3csyh	629	30	and	and	CC
cord-270892-ycc3csyh	629	31	overlapping	overlap	VBG
cord-270892-ycc3csyh	629	32	effects	effect	NNS
cord-270892-ycc3csyh	629	33	caused	cause	VBN
cord-270892-ycc3csyh	629	34	by	by	IN
cord-270892-ycc3csyh	629	35	the	the	DT
cord-270892-ycc3csyh	629	36	multitude	multitude	NN
cord-270892-ycc3csyh	629	37	of	of	IN
cord-270892-ycc3csyh	629	38	evolutionary	evolutionary	JJ
cord-270892-ycc3csyh	629	39	trimmed	trim	VBN
cord-270892-ycc3csyh	629	40	metabolites	metabolite	NNS
cord-270892-ycc3csyh	629	41	,	,	,
cord-270892-ycc3csyh	629	42	which	which	WDT
cord-270892-ycc3csyh	629	43	may	may	MD
cord-270892-ycc3csyh	629	44	attribute	attribute	VB
cord-270892-ycc3csyh	629	45	with	with	IN
cord-270892-ycc3csyh	629	46	modulating	modulate	VBG
cord-270892-ycc3csyh	629	47	multi	multi	JJ
cord-270892-ycc3csyh	629	48	-	-	JJ
cord-270892-ycc3csyh	629	49	target	target	JJ
cord-270892-ycc3csyh	629	50	effects	effect	NNS
cord-270892-ycc3csyh	629	51	.	.	.
cord-270892-ycc3csyh	630	1	On	on	IN
cord-270892-ycc3csyh	630	2	the	the	DT
cord-270892-ycc3csyh	630	3	other	other	JJ
cord-270892-ycc3csyh	630	4	side	side	NN
cord-270892-ycc3csyh	630	5	,	,	,
cord-270892-ycc3csyh	630	6	exactly	exactly	RB
cord-270892-ycc3csyh	630	7	this	this	DT
cord-270892-ycc3csyh	630	8	fact	fact	NN
cord-270892-ycc3csyh	630	9	is	be	VBZ
cord-270892-ycc3csyh	630	10	hardly	hardly	RB
cord-270892-ycc3csyh	630	11	compatible	compatible	JJ
cord-270892-ycc3csyh	630	12	with	with	IN
cord-270892-ycc3csyh	630	13	the	the	DT
cord-270892-ycc3csyh	630	14	proper	proper	JJ
cord-270892-ycc3csyh	630	15	assignment	assignment	NN
cord-270892-ycc3csyh	630	16	of	of	IN
cord-270892-ycc3csyh	630	17	an	an	DT
cord-270892-ycc3csyh	630	18	activity	activity	NN
cord-270892-ycc3csyh	630	19	to	to	IN
cord-270892-ycc3csyh	630	20	a	a	DT
cord-270892-ycc3csyh	630	21	defined	define	VBN
cord-270892-ycc3csyh	630	22	chemical	chemical	NN
cord-270892-ycc3csyh	630	23	entity	entity	NN
cord-270892-ycc3csyh	630	24	according	accord	VBG
cord-270892-ycc3csyh	630	25	to	to	IN
cord-270892-ycc3csyh	630	26	Western	western	JJ
cord-270892-ycc3csyh	630	27	medical	medical	JJ
cord-270892-ycc3csyh	630	28	practise	practise	NN
cord-270892-ycc3csyh	630	29	.	.	.
cord-270892-ycc3csyh	631	1	In	in	IN
cord-270892-ycc3csyh	631	2	contrast	contrast	NN
cord-270892-ycc3csyh	631	3	to	to	IN
cord-270892-ycc3csyh	631	4	a	a	DT
cord-270892-ycc3csyh	631	5	single	single	JJ
cord-270892-ycc3csyh	631	6	compound	compound	NN
cord-270892-ycc3csyh	631	7	(	(	-LRB-
cord-270892-ycc3csyh	631	8	synthetic	synthetic	JJ
cord-270892-ycc3csyh	631	9	or	or	CC
cord-270892-ycc3csyh	631	10	naturally	naturally	RB
cord-270892-ycc3csyh	631	11	based	base	VBN
cord-270892-ycc3csyh	631	12	)	)	-RRB-
cord-270892-ycc3csyh	631	13	,	,	,
cord-270892-ycc3csyh	631	14	the	the	DT
cord-270892-ycc3csyh	631	15	chemistry	chemistry	NN
cord-270892-ycc3csyh	631	16	of	of	IN
cord-270892-ycc3csyh	631	17	a	a	DT
cord-270892-ycc3csyh	631	18	botanical	botanical	NN
cord-270892-ycc3csyh	631	19	is	be	VBZ
cord-270892-ycc3csyh	631	20	not	not	RB
cord-270892-ycc3csyh	631	21	only	only	RB
cord-270892-ycc3csyh	631	22	complex	complex	JJ
cord-270892-ycc3csyh	631	23	but	but	CC
cord-270892-ycc3csyh	631	24	also	also	RB
cord-270892-ycc3csyh	631	25	varying	vary	VBG
cord-270892-ycc3csyh	631	26	.	.	.
cord-270892-ycc3csyh	632	1	The	the	DT
cord-270892-ycc3csyh	632	2	analytical	analytical	JJ
cord-270892-ycc3csyh	632	3	profile	profile	NN
cord-270892-ycc3csyh	632	4	and	and	CC
cord-270892-ycc3csyh	632	5	in	in	IN
cord-270892-ycc3csyh	632	6	term	term	NN
cord-270892-ycc3csyh	632	7	the	the	DT
cord-270892-ycc3csyh	632	8	pharmacological	pharmacological	JJ
cord-270892-ycc3csyh	632	9	profile	profile	NN
cord-270892-ycc3csyh	632	10	of	of	IN
cord-270892-ycc3csyh	632	11	the	the	DT
cord-270892-ycc3csyh	632	12	investigated	investigate	VBN
cord-270892-ycc3csyh	632	13	samples	sample	NNS
cord-270892-ycc3csyh	632	14	can	can	MD
cord-270892-ycc3csyh	632	15	differ	differ	VB
cord-270892-ycc3csyh	632	16	substantially	substantially	RB
cord-270892-ycc3csyh	632	17	.	.	.
cord-270892-ycc3csyh	633	1	Accordingly	accordingly	RB
cord-270892-ycc3csyh	633	2	,	,	,
cord-270892-ycc3csyh	633	3	the	the	DT
cord-270892-ycc3csyh	633	4	quantitative	quantitative	JJ
cord-270892-ycc3csyh	633	5	and	and	CC
cord-270892-ycc3csyh	633	6	qualitative	qualitative	JJ
cord-270892-ycc3csyh	633	7	comparison	comparison	NN
cord-270892-ycc3csyh	633	8	of	of	IN
cord-270892-ycc3csyh	633	9	different	different	JJ
cord-270892-ycc3csyh	633	10	studies	study	NNS
cord-270892-ycc3csyh	633	11	resulting	result	VBG
cord-270892-ycc3csyh	633	12	from	from	IN
cord-270892-ycc3csyh	633	13	botanicals	botanical	NNS
cord-270892-ycc3csyh	633	14	is	be	VBZ
cord-270892-ycc3csyh	633	15	by	by	IN
cord-270892-ycc3csyh	633	16	far	far	RB
cord-270892-ycc3csyh	633	17	more	more	RBR
cord-270892-ycc3csyh	633	18	complex	complex	JJ
cord-270892-ycc3csyh	633	19	than	than	IN
cord-270892-ycc3csyh	633	20	those	those	DT
cord-270892-ycc3csyh	633	21	performed	perform	VBN
cord-270892-ycc3csyh	633	22	with	with	IN
cord-270892-ycc3csyh	633	23	pure	pure	JJ
cord-270892-ycc3csyh	633	24	single	single	JJ
cord-270892-ycc3csyh	633	25	compounds	compound	NNS
cord-270892-ycc3csyh	633	26	,	,	,
cord-270892-ycc3csyh	633	27	and	and	CC
cord-270892-ycc3csyh	633	28	may	may	MD
cord-270892-ycc3csyh	633	29	also	also	RB
cord-270892-ycc3csyh	633	30	explain	explain	VB
cord-270892-ycc3csyh	633	31	why	why	WRB
cord-270892-ycc3csyh	633	32	so	so	RB
cord-270892-ycc3csyh	633	33	little	little	JJ
cord-270892-ycc3csyh	633	34	emphasis	emphasis	NN
cord-270892-ycc3csyh	633	35	from	from	IN
cord-270892-ycc3csyh	633	36	pharmaceutical	pharmaceutical	JJ
cord-270892-ycc3csyh	633	37	industry	industry	NN
cord-270892-ycc3csyh	633	38	has	have	VBZ
cord-270892-ycc3csyh	633	39	been	be	VBN
cord-270892-ycc3csyh	633	40	put	put	VBN
cord-270892-ycc3csyh	633	41	into	into	IN
cord-270892-ycc3csyh	633	42	the	the	DT
cord-270892-ycc3csyh	633	43	further	further	JJ
cord-270892-ycc3csyh	633	44	development	development	NN
cord-270892-ycc3csyh	633	45	of	of	IN
cord-270892-ycc3csyh	633	46	even	even	RB
cord-270892-ycc3csyh	633	47	promising	promising	JJ
cord-270892-ycc3csyh	633	48	natural	natural	JJ
cord-270892-ycc3csyh	633	49	preparations	preparation	NNS
cord-270892-ycc3csyh	633	50	.	.	.
cord-270892-ycc3csyh	634	1	In	in	IN
cord-270892-ycc3csyh	634	2	general	general	JJ
cord-270892-ycc3csyh	634	3	,	,	,
cord-270892-ycc3csyh	634	4	the	the	DT
cord-270892-ycc3csyh	634	5	search	search	NN
cord-270892-ycc3csyh	634	6	for	for	IN
cord-270892-ycc3csyh	634	7	potent	potent	JJ
cord-270892-ycc3csyh	634	8	,	,	,
cord-270892-ycc3csyh	634	9	selective	selective	JJ
cord-270892-ycc3csyh	634	10	,	,	,
cord-270892-ycc3csyh	634	11	nontoxic	nontoxic	JJ
cord-270892-ycc3csyh	634	12	compounds	compound	NNS
cord-270892-ycc3csyh	634	13	that	that	WDT
cord-270892-ycc3csyh	634	14	might	may	MD
cord-270892-ycc3csyh	634	15	be	be	VB
cord-270892-ycc3csyh	634	16	developed	develop	VBN
cord-270892-ycc3csyh	634	17	further	further	RB
cord-270892-ycc3csyh	634	18	to	to	IN
cord-270892-ycc3csyh	634	19	a	a	DT
cord-270892-ycc3csyh	634	20	drug	drug	NN
cord-270892-ycc3csyh	634	21	substance	substance	NN
cord-270892-ycc3csyh	634	22	is	be	VBZ
cord-270892-ycc3csyh	634	23	a	a	DT
cord-270892-ycc3csyh	634	24	multidisciplinary	multidisciplinary	JJ
cord-270892-ycc3csyh	634	25	,	,	,
cord-270892-ycc3csyh	634	26	time	time	NN
cord-270892-ycc3csyh	634	27	-	-	HYPH
cord-270892-ycc3csyh	634	28	and	and	CC
cord-270892-ycc3csyh	634	29	cost	cost	NN
cord-270892-ycc3csyh	634	30	-	-	HYPH
cord-270892-ycc3csyh	634	31	consuming	consume	VBG
cord-270892-ycc3csyh	634	32	process	process	NN
cord-270892-ycc3csyh	634	33	.	.	.
cord-270892-ycc3csyh	635	1	Therefore	therefore	RB
cord-270892-ycc3csyh	635	2	,	,	,
cord-270892-ycc3csyh	635	3	strategies	strategy	NNS
cord-270892-ycc3csyh	635	4	for	for	IN
cord-270892-ycc3csyh	635	5	a	a	DT
cord-270892-ycc3csyh	635	6	target	target	NN
cord-270892-ycc3csyh	635	7	-	-	HYPH
cord-270892-ycc3csyh	635	8	oriented	orient	VBN
cord-270892-ycc3csyh	635	9	discovery	discovery	NN
cord-270892-ycc3csyh	635	10	of	of	IN
cord-270892-ycc3csyh	635	11	lead	lead	NN
cord-270892-ycc3csyh	635	12	-	-	HYPH
cord-270892-ycc3csyh	635	13	structures	structure	NNS
cord-270892-ycc3csyh	635	14	either	either	CC
cord-270892-ycc3csyh	635	15	from	from	IN
cord-270892-ycc3csyh	635	16	nature	nature	NN
cord-270892-ycc3csyh	635	17	or	or	CC
cord-270892-ycc3csyh	635	18	synthesis	synthesis	NN
cord-270892-ycc3csyh	635	19	are	be	VBP
cord-270892-ycc3csyh	635	20	in	in	IN
cord-270892-ycc3csyh	635	21	high	high	JJ
cord-270892-ycc3csyh	635	22	demand	demand	NN
cord-270892-ycc3csyh	635	23	.	.	.
cord-270892-ycc3csyh	636	1	Some	some	DT
cord-270892-ycc3csyh	636	2	of	of	IN
cord-270892-ycc3csyh	636	3	them	-PRON-	PRP
cord-270892-ycc3csyh	636	4	will	will	MD
cord-270892-ycc3csyh	636	5	be	be	VB
cord-270892-ycc3csyh	636	6	discussed	discuss	VBN
cord-270892-ycc3csyh	636	7	in	in	IN
cord-270892-ycc3csyh	636	8	the	the	DT
cord-270892-ycc3csyh	636	9	following	follow	VBG
cord-270892-ycc3csyh	636	10	section	section	NN
cord-270892-ycc3csyh	636	11	,	,	,
cord-270892-ycc3csyh	636	12	providing	provide	VBG
cord-270892-ycc3csyh	636	13	examples	example	NNS
cord-270892-ycc3csyh	636	14	from	from	IN
cord-270892-ycc3csyh	636	15	anti	anti	JJ
cord-270892-ycc3csyh	636	16	-	-	JJ
cord-270892-ycc3csyh	636	17	HRV	HRV	NNP
cord-270892-ycc3csyh	636	18	research	research	NN
cord-270892-ycc3csyh	636	19	.	.	.
cord-270892-ycc3csyh	637	1	As	as	IN
cord-270892-ycc3csyh	637	2	already	already	RB
cord-270892-ycc3csyh	637	3	mentioned	mention	VBN
cord-270892-ycc3csyh	637	4	,	,	,
cord-270892-ycc3csyh	637	5	nature	nature	NN
cord-270892-ycc3csyh	637	6	provides	provide	VBZ
cord-270892-ycc3csyh	637	7	an	an	DT
cord-270892-ycc3csyh	637	8	extremely	extremely	RB
cord-270892-ycc3csyh	637	9	rich	rich	JJ
cord-270892-ycc3csyh	637	10	pool	pool	NN
cord-270892-ycc3csyh	637	11	of	of	IN
cord-270892-ycc3csyh	637	12	bioactive	bioactive	JJ
cord-270892-ycc3csyh	637	13	natural	natural	JJ
cord-270892-ycc3csyh	637	14	products	product	NNS
cord-270892-ycc3csyh	637	15	.	.	.
cord-270892-ycc3csyh	638	1	It	-PRON-	PRP
cord-270892-ycc3csyh	638	2	is	be	VBZ
cord-270892-ycc3csyh	638	3	however	however	RB
cord-270892-ycc3csyh	638	4	a	a	DT
cord-270892-ycc3csyh	638	5	challenging	challenging	JJ
cord-270892-ycc3csyh	638	6	endeavor	endeavor	NN
cord-270892-ycc3csyh	638	7	to	to	TO
cord-270892-ycc3csyh	638	8	find	find	VB
cord-270892-ycc3csyh	638	9	exactly	exactly	RB
cord-270892-ycc3csyh	638	10	those	those	DT
cord-270892-ycc3csyh	638	11	compounds	compound	NNS
cord-270892-ycc3csyh	638	12	that	that	WDT
cord-270892-ycc3csyh	638	13	show	show	VBP
cord-270892-ycc3csyh	638	14	an	an	DT
cord-270892-ycc3csyh	638	15	activity	activity	NN
cord-270892-ycc3csyh	638	16	on	on	IN
cord-270892-ycc3csyh	638	17	the	the	DT
cord-270892-ycc3csyh	638	18	focused	focused	JJ
cord-270892-ycc3csyh	638	19	target	target	NN
cord-270892-ycc3csyh	638	20	.	.	.
cord-270892-ycc3csyh	639	1	In	in	IN
cord-270892-ycc3csyh	639	2	natural	natural	JJ
cord-270892-ycc3csyh	639	3	product	product	NN
cord-270892-ycc3csyh	639	4	research	research	NN
cord-270892-ycc3csyh	639	5	hints	hint	VBZ
cord-270892-ycc3csyh	639	6	from	from	IN
cord-270892-ycc3csyh	639	7	folk	folk	NN
cord-270892-ycc3csyh	639	8	medicine	medicine	NN
cord-270892-ycc3csyh	639	9	are	be	VBP
cord-270892-ycc3csyh	639	10	a	a	DT
cord-270892-ycc3csyh	639	11	valuable	valuable	JJ
cord-270892-ycc3csyh	639	12	starting	starting	NN
cord-270892-ycc3csyh	639	13	point	point	NN
cord-270892-ycc3csyh	639	14	to	to	TO
cord-270892-ycc3csyh	639	15	dig	dig	VB
cord-270892-ycc3csyh	639	16	for	for	IN
cord-270892-ycc3csyh	639	17	lead	lead	JJ
cord-270892-ycc3csyh	639	18	structures	structure	NNS
cord-270892-ycc3csyh	639	19	of	of	IN
cord-270892-ycc3csyh	639	20	certain	certain	JJ
cord-270892-ycc3csyh	639	21	interest	interest	NN
cord-270892-ycc3csyh	639	22	.	.	.
cord-270892-ycc3csyh	640	1	The	the	DT
cord-270892-ycc3csyh	640	2	majority	majority	NN
cord-270892-ycc3csyh	640	3	of	of	IN
cord-270892-ycc3csyh	640	4	active	active	JJ
cord-270892-ycc3csyh	640	5	principles	principle	NNS
cord-270892-ycc3csyh	640	6	from	from	IN
cord-270892-ycc3csyh	640	7	higher	high	JJR
cord-270892-ycc3csyh	640	8	plants	plant	NNS
cord-270892-ycc3csyh	640	9	has	have	VBZ
cord-270892-ycc3csyh	640	10	been	be	VBN
cord-270892-ycc3csyh	640	11	discovered	discover	VBN
cord-270892-ycc3csyh	640	12	as	as	IN
cord-270892-ycc3csyh	640	13	a	a	DT
cord-270892-ycc3csyh	640	14	result	result	NN
cord-270892-ycc3csyh	640	15	of	of	IN
cord-270892-ycc3csyh	640	16	ethnopharmacologically	ethnopharmacologically	RB
cord-270892-ycc3csyh	640	17	directed	direct	VBN
cord-270892-ycc3csyh	640	18	pharmacognostic	pharmacognostic	JJ
cord-270892-ycc3csyh	640	19	research	research	NN
cord-270892-ycc3csyh	640	20	.	.	.
cord-270892-ycc3csyh	641	1	312	312	CD
cord-270892-ycc3csyh	641	2	,	,	,
cord-270892-ycc3csyh	641	3	313	313	CD
cord-270892-ycc3csyh	641	4	Oral	oral	JJ
cord-270892-ycc3csyh	641	5	or	or	CC
cord-270892-ycc3csyh	641	6	written	write	VBN
cord-270892-ycc3csyh	641	7	indications	indication	NNS
cord-270892-ycc3csyh	641	8	for	for	IN
cord-270892-ycc3csyh	641	9	a	a	DT
cord-270892-ycc3csyh	641	10	beneficial	beneficial	JJ
cord-270892-ycc3csyh	641	11	application	application	NN
cord-270892-ycc3csyh	641	12	of	of	IN
cord-270892-ycc3csyh	641	13	a	a	DT
cord-270892-ycc3csyh	641	14	natural	natural	JJ
cord-270892-ycc3csyh	641	15	material	material	NN
cord-270892-ycc3csyh	641	16	first	first	RB
cord-270892-ycc3csyh	641	17	need	need	VBP
cord-270892-ycc3csyh	641	18	a	a	DT
cord-270892-ycc3csyh	641	19	critical	critical	JJ
cord-270892-ycc3csyh	641	20	evaluation	evaluation	NN
cord-270892-ycc3csyh	641	21	as	as	IN
cord-270892-ycc3csyh	641	22	to	to	IN
cord-270892-ycc3csyh	641	23	the	the	DT
cord-270892-ycc3csyh	641	24	selection	selection	NN
cord-270892-ycc3csyh	641	25	of	of	IN
cord-270892-ycc3csyh	641	26	the	the	DT
cord-270892-ycc3csyh	641	27	correct	correct	JJ
cord-270892-ycc3csyh	641	28	material	material	NN
cord-270892-ycc3csyh	641	29	,	,	,
cord-270892-ycc3csyh	641	30	its	-PRON-	PRP$
cord-270892-ycc3csyh	641	31	medicinal	medicinal	JJ
cord-270892-ycc3csyh	641	32	preparation	preparation	NN
cord-270892-ycc3csyh	641	33	,	,	,
cord-270892-ycc3csyh	641	34	the	the	DT
cord-270892-ycc3csyh	641	35	kind	kind	NN
cord-270892-ycc3csyh	641	36	of	of	IN
cord-270892-ycc3csyh	641	37	application	application	NN
cord-270892-ycc3csyh	641	38	,	,	,
cord-270892-ycc3csyh	641	39	and	and	CC
cord-270892-ycc3csyh	641	40	overall	overall	RB
cord-270892-ycc3csyh	641	41	the	the	DT
cord-270892-ycc3csyh	641	42	pharmacological	pharmacological	JJ
cord-270892-ycc3csyh	641	43	profile	profile	NN
cord-270892-ycc3csyh	641	44	.	.	.
cord-270892-ycc3csyh	642	1	A	a	DT
cord-270892-ycc3csyh	642	2	rational	rational	JJ
cord-270892-ycc3csyh	642	3	criticism	criticism	NN
cord-270892-ycc3csyh	642	4	of	of	IN
cord-270892-ycc3csyh	642	5	often	often	RB
cord-270892-ycc3csyh	642	6	anecdotal	anecdotal	JJ
cord-270892-ycc3csyh	642	7	efficacy	efficacy	NN
cord-270892-ycc3csyh	642	8	from	from	IN
cord-270892-ycc3csyh	642	9	traditional	traditional	JJ
cord-270892-ycc3csyh	642	10	medicine	medicine	NN
cord-270892-ycc3csyh	642	11	is	be	VBZ
cord-270892-ycc3csyh	642	12	a	a	DT
cord-270892-ycc3csyh	642	13	mandatory	mandatory	JJ
cord-270892-ycc3csyh	642	14	attitude	attitude	NN
cord-270892-ycc3csyh	642	15	to	to	TO
cord-270892-ycc3csyh	642	16	avoid	avoid	VB
cord-270892-ycc3csyh	642	17	overinterpretation	overinterpretation	NN
cord-270892-ycc3csyh	642	18	of	of	IN
cord-270892-ycc3csyh	642	19	handed	hand	VBN
cord-270892-ycc3csyh	642	20	-	-	HYPH
cord-270892-ycc3csyh	642	21	down	down	RP
cord-270892-ycc3csyh	642	22	information	information	NN
cord-270892-ycc3csyh	642	23	.	.	.
cord-270892-ycc3csyh	643	1	314	314	CD
cord-270892-ycc3csyh	644	1	In	in	IN
cord-270892-ycc3csyh	644	2	case	case	NN
cord-270892-ycc3csyh	644	3	of	of	IN
cord-270892-ycc3csyh	644	4	pretended	pretended	JJ
cord-270892-ycc3csyh	644	5	anti	anti	JJ
cord-270892-ycc3csyh	644	6	-	-	JJ
cord-270892-ycc3csyh	644	7	HRV	HRV	NNP
cord-270892-ycc3csyh	644	8	remedies	remedy	NNS
cord-270892-ycc3csyh	644	9	,	,	,
cord-270892-ycc3csyh	644	10	the	the	DT
cord-270892-ycc3csyh	644	11	reported	report	VBN
cord-270892-ycc3csyh	644	12	biological	biological	JJ
cord-270892-ycc3csyh	644	13	efficacy	efficacy	NN
cord-270892-ycc3csyh	644	14	obviously	obviously	RB
cord-270892-ycc3csyh	644	15	suffers	suffer	VBZ
cord-270892-ycc3csyh	644	16	from	from	IN
cord-270892-ycc3csyh	644	17	being	be	VBG
cord-270892-ycc3csyh	644	18	restricted	restrict	VBN
cord-270892-ycc3csyh	644	19	to	to	IN
cord-270892-ycc3csyh	644	20	respiratory	respiratory	JJ
cord-270892-ycc3csyh	644	21	diseases	disease	NNS
cord-270892-ycc3csyh	644	22	,	,	,
cord-270892-ycc3csyh	644	23	which	which	WDT
cord-270892-ycc3csyh	644	24	might	may	MD
cord-270892-ycc3csyh	644	25	be	be	VB
cord-270892-ycc3csyh	644	26	caused	cause	VBN
cord-270892-ycc3csyh	644	27	by	by	IN
cord-270892-ycc3csyh	644	28	a	a	DT
cord-270892-ycc3csyh	644	29	panel	panel	NN
cord-270892-ycc3csyh	644	30	of	of	IN
cord-270892-ycc3csyh	644	31	bacterial	bacterial	JJ
cord-270892-ycc3csyh	644	32	or	or	CC
cord-270892-ycc3csyh	644	33	viral	viral	JJ
cord-270892-ycc3csyh	644	34	infections	infection	NNS
cord-270892-ycc3csyh	644	35	.	.	.
cord-270892-ycc3csyh	645	1	Thus	thus	RB
cord-270892-ycc3csyh	645	2	,	,	,
cord-270892-ycc3csyh	645	3	an	an	DT
cord-270892-ycc3csyh	645	4	approved	approve	VBN
cord-270892-ycc3csyh	645	5	remedy	remedy	NN
cord-270892-ycc3csyh	645	6	may	may	MD
cord-270892-ycc3csyh	645	7	affect	affect	VB
cord-270892-ycc3csyh	645	8	the	the	DT
cord-270892-ycc3csyh	645	9	microbes	microbe	NNS
cord-270892-ycc3csyh	645	10	,	,	,
cord-270892-ycc3csyh	645	11	or	or	CC
cord-270892-ycc3csyh	645	12	show	show	VB
cord-270892-ycc3csyh	645	13	an	an	DT
cord-270892-ycc3csyh	645	14	immune	immune	JJ
cord-270892-ycc3csyh	645	15	modulating	modulating	NN
cord-270892-ycc3csyh	645	16	or	or	CC
cord-270892-ycc3csyh	645	17	even	even	RB
cord-270892-ycc3csyh	645	18	antiinflammatory	antiinflammatory	JJ
cord-270892-ycc3csyh	645	19	effect	effect	NN
cord-270892-ycc3csyh	645	20	,	,	,
cord-270892-ycc3csyh	645	21	or	or	CC
cord-270892-ycc3csyh	645	22	a	a	DT
cord-270892-ycc3csyh	645	23	combination	combination	NN
cord-270892-ycc3csyh	645	24	of	of	IN
cord-270892-ycc3csyh	645	25	these	these	DT
cord-270892-ycc3csyh	645	26	.	.	.
cord-270892-ycc3csyh	646	1	The	the	DT
cord-270892-ycc3csyh	646	2	holistic	holistic	JJ
cord-270892-ycc3csyh	646	3	access	access	NN
cord-270892-ycc3csyh	646	4	is	be	VBZ
cord-270892-ycc3csyh	646	5	an	an	DT
cord-270892-ycc3csyh	646	6	innate	innate	JJ
cord-270892-ycc3csyh	646	7	character	character	NN
cord-270892-ycc3csyh	646	8	of	of	IN
cord-270892-ycc3csyh	646	9	ethnopharmacology	ethnopharmacology	NN
cord-270892-ycc3csyh	646	10	and	and	CC
cord-270892-ycc3csyh	646	11	needs	need	VBZ
cord-270892-ycc3csyh	646	12	to	to	TO
cord-270892-ycc3csyh	646	13	be	be	VB
cord-270892-ycc3csyh	646	14	tracked	track	VBN
cord-270892-ycc3csyh	646	15	down	down	RP
cord-270892-ycc3csyh	646	16	to	to	IN
cord-270892-ycc3csyh	646	17	the	the	DT
cord-270892-ycc3csyh	646	18	specifically	specifically	RB
cord-270892-ycc3csyh	646	19	involved	involve	VBN
cord-270892-ycc3csyh	646	20	target	target	NN
cord-270892-ycc3csyh	646	21	/	/	SYM
cord-270892-ycc3csyh	646	22	s	s	NN
cord-270892-ycc3csyh	646	23	.	.	.
cord-270892-ycc3csyh	647	1	In	in	IN
cord-270892-ycc3csyh	647	2	a	a	DT
cord-270892-ycc3csyh	647	3	recently	recently	RB
cord-270892-ycc3csyh	647	4	published	publish	VBN
cord-270892-ycc3csyh	647	5	study	study	NN
cord-270892-ycc3csyh	647	6	focusing	focus	VBG
cord-270892-ycc3csyh	647	7	on	on	IN
cord-270892-ycc3csyh	647	8	the	the	DT
cord-270892-ycc3csyh	647	9	discovery	discovery	NN
cord-270892-ycc3csyh	647	10	of	of	IN
cord-270892-ycc3csyh	647	11	HRV	HRV	NNP
cord-270892-ycc3csyh	647	12	-	-	HYPH
cord-270892-ycc3csyh	647	13	capsid	capsid	NN
cord-270892-ycc3csyh	647	14	binders	binder	NNS
cord-270892-ycc3csyh	647	15	from	from	IN
cord-270892-ycc3csyh	647	16	nature	nature	NN
cord-270892-ycc3csyh	647	17	using	use	VBG
cord-270892-ycc3csyh	647	18	a	a	DT
cord-270892-ycc3csyh	647	19	pharmacophore	pharmacophore	NN
cord-270892-ycc3csyh	647	20	-	-	HYPH
cord-270892-ycc3csyh	647	21	based	base	VBN
cord-270892-ycc3csyh	647	22	virtual	virtual	JJ
cord-270892-ycc3csyh	647	23	screening	screening	NN
cord-270892-ycc3csyh	647	24	of	of	IN
cord-270892-ycc3csyh	647	25	an	an	DT
cord-270892-ycc3csyh	647	26	ethnopharmacologically	ethnopharmacologically	RB
cord-270892-ycc3csyh	647	27	biased	bias	VBN
cord-270892-ycc3csyh	647	28	3D	3d	JJ
cord-270892-ycc3csyh	647	29	-	-	HYPH
cord-270892-ycc3csyh	647	30	multiconformational	multiconformational	JJ
cord-270892-ycc3csyh	647	31	database	database	NN
cord-270892-ycc3csyh	647	32	,	,	,
cord-270892-ycc3csyh	647	33	some	some	DT
cord-270892-ycc3csyh	647	34	30	30	CD
cord-270892-ycc3csyh	647	35	secondary	secondary	JJ
cord-270892-ycc3csyh	647	36	metabolites	metabolite	NNS
cord-270892-ycc3csyh	647	37	were	be	VBD
cord-270892-ycc3csyh	647	38	predicted	predict	VBN
cord-270892-ycc3csyh	647	39	to	to	TO
cord-270892-ycc3csyh	647	40	act	act	VB
cord-270892-ycc3csyh	647	41	as	as	IN
cord-270892-ycc3csyh	647	42	capsid	capsid	RB
cord-270892-ycc3csyh	647	43	-	-	HYPH
cord-270892-ycc3csyh	647	44	binding	bind	VBG
cord-270892-ycc3csyh	647	45	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	647	46	of	of	IN
cord-270892-ycc3csyh	647	47	HRV	HRV	NNP
cord-270892-ycc3csyh	647	48	.	.	.
cord-270892-ycc3csyh	648	1	144	144	CD
cord-270892-ycc3csyh	649	1	For	for	IN
cord-270892-ycc3csyh	649	2	an	an	DT
cord-270892-ycc3csyh	649	3	in	in	IN
cord-270892-ycc3csyh	649	4	depth	depth	NN
cord-270892-ycc3csyh	649	5	phytochemical	phytochemical	JJ
cord-270892-ycc3csyh	649	6	and	and	CC
cord-270892-ycc3csyh	649	7	pharmacological	pharmacological	JJ
cord-270892-ycc3csyh	649	8	investigation	investigation	NN
cord-270892-ycc3csyh	649	9	,	,	,
cord-270892-ycc3csyh	649	10	it	-PRON-	PRP
cord-270892-ycc3csyh	649	11	was	be	VBD
cord-270892-ycc3csyh	649	12	mandatory	mandatory	JJ
cord-270892-ycc3csyh	649	13	to	to	TO
cord-270892-ycc3csyh	649	14	focus	focus	VB
cord-270892-ycc3csyh	649	15	on	on	IN
cord-270892-ycc3csyh	649	16	one	one	CD
cord-270892-ycc3csyh	649	17	promising	promise	VBG
cord-270892-ycc3csyh	649	18	natural	natural	JJ
cord-270892-ycc3csyh	649	19	material	material	NN
cord-270892-ycc3csyh	649	20	.	.	.
cord-270892-ycc3csyh	650	1	Thus	thus	RB
cord-270892-ycc3csyh	650	2	,	,	,
cord-270892-ycc3csyh	650	3	we	-PRON-	PRP
cord-270892-ycc3csyh	650	4	consulted	consult	VBD
cord-270892-ycc3csyh	650	5	the	the	DT
cord-270892-ycc3csyh	650	6	ethnobotanical	ethnobotanical	JJ
cord-270892-ycc3csyh	650	7	source	source	NN
cord-270892-ycc3csyh	650	8	Materia	Materia	NNP
cord-270892-ycc3csyh	650	9	medica	medica	NNP
cord-270892-ycc3csyh	650	10	,	,	,
cord-270892-ycc3csyh	650	11	which	which	WDT
cord-270892-ycc3csyh	650	12	was	be	VBD
cord-270892-ycc3csyh	650	13	written	write	VBN
cord-270892-ycc3csyh	650	14	by	by	IN
cord-270892-ycc3csyh	650	15	Pedanius	Pedanius	NNP
cord-270892-ycc3csyh	650	16	Dioscorides	Dioscorides	NNP
cord-270892-ycc3csyh	650	17	in	in	IN
cord-270892-ycc3csyh	650	18	the	the	DT
cord-270892-ycc3csyh	650	19	1	1	CD
cord-270892-ycc3csyh	650	20	st	st	NNP
cord-270892-ycc3csyh	650	21	century	century	NN
cord-270892-ycc3csyh	650	22	AD	AD	NNP
cord-270892-ycc3csyh	650	23	.	.	.
cord-270892-ycc3csyh	651	1	The	the	DT
cord-270892-ycc3csyh	651	2	treatise	treatise	NN
cord-270892-ycc3csyh	651	3	consisting	consist	VBG
cord-270892-ycc3csyh	651	4	of	of	IN
cord-270892-ycc3csyh	651	5	five	five	CD
cord-270892-ycc3csyh	651	6	books	book	NNS
cord-270892-ycc3csyh	651	7	comprises	comprise	VBZ
cord-270892-ycc3csyh	651	8	some	some	DT
cord-270892-ycc3csyh	651	9	1,000	1,000	CD
cord-270892-ycc3csyh	651	10	or	or	CC
cord-270892-ycc3csyh	651	11	so	so	RB
cord-270892-ycc3csyh	651	12	drugs	drug	NNS
cord-270892-ycc3csyh	651	13	derived	derive	VBN
cord-270892-ycc3csyh	651	14	from	from	IN
cord-270892-ycc3csyh	651	15	minerals	mineral	NNS
cord-270892-ycc3csyh	651	16	,	,	,
cord-270892-ycc3csyh	651	17	animals	animal	NNS
cord-270892-ycc3csyh	651	18	,	,	,
cord-270892-ycc3csyh	651	19	and	and	CC
cord-270892-ycc3csyh	651	20	the	the	DT
cord-270892-ycc3csyh	651	21	majority	majority	NN
cord-270892-ycc3csyh	651	22	of	of	IN
cord-270892-ycc3csyh	651	23	them	-PRON-	PRP
cord-270892-ycc3csyh	651	24	from	from	IN
cord-270892-ycc3csyh	651	25	plants	plant	NNS
cord-270892-ycc3csyh	651	26	(	(	-LRB-
cord-270892-ycc3csyh	651	27	800	800	CD
cord-270892-ycc3csyh	651	28	)	)	-RRB-
cord-270892-ycc3csyh	651	29	.	.	.
cord-270892-ycc3csyh	652	1	It	-PRON-	PRP
cord-270892-ycc3csyh	652	2	represents	represent	VBZ
cord-270892-ycc3csyh	652	3	a	a	DT
cord-270892-ycc3csyh	652	4	great	great	JJ
cord-270892-ycc3csyh	652	5	repository	repository	NN
cord-270892-ycc3csyh	652	6	of	of	IN
cord-270892-ycc3csyh	652	7	botanical	botanical	JJ
cord-270892-ycc3csyh	652	8	,	,	,
cord-270892-ycc3csyh	652	9	medical	medical	JJ
cord-270892-ycc3csyh	652	10	,	,	,
cord-270892-ycc3csyh	652	11	and	and	CC
cord-270892-ycc3csyh	652	12	pharmacological	pharmacological	JJ
cord-270892-ycc3csyh	652	13	lore	lore	NN
cord-270892-ycc3csyh	652	14	.	.	.
cord-270892-ycc3csyh	653	1	Scrutinizing	scrutinize	VBG
cord-270892-ycc3csyh	653	2	the	the	DT
cord-270892-ycc3csyh	653	3	natural	natural	JJ
cord-270892-ycc3csyh	653	4	materials	material	NNS
cord-270892-ycc3csyh	653	5	underlying	underlie	VBG
cord-270892-ycc3csyh	653	6	the	the	DT
cord-270892-ycc3csyh	653	7	obtained	obtain	VBN
cord-270892-ycc3csyh	653	8	virtual	virtual	JJ
cord-270892-ycc3csyh	653	9	hits	hit	NNS
cord-270892-ycc3csyh	653	10	we	-PRON-	PRP
cord-270892-ycc3csyh	653	11	came	come	VBD
cord-270892-ycc3csyh	653	12	across	across	IN
cord-270892-ycc3csyh	653	13	asafetida	asafetida	NNP
cord-270892-ycc3csyh	653	14	,	,	,
cord-270892-ycc3csyh	653	15	which	which	WDT
cord-270892-ycc3csyh	653	16	is	be	VBZ
cord-270892-ycc3csyh	653	17	a	a	DT
cord-270892-ycc3csyh	653	18	gum	gum	NN
cord-270892-ycc3csyh	653	19	resin	resin	NN
cord-270892-ycc3csyh	653	20	gained	gain	VBN
cord-270892-ycc3csyh	653	21	from	from	IN
cord-270892-ycc3csyh	653	22	the	the	DT
cord-270892-ycc3csyh	653	23	roots	root	NNS
cord-270892-ycc3csyh	653	24	of	of	IN
cord-270892-ycc3csyh	653	25	a	a	DT
cord-270892-ycc3csyh	653	26	variety	variety	NN
cord-270892-ycc3csyh	653	27	of	of	IN
cord-270892-ycc3csyh	653	28	foul	foul	RB
cord-270892-ycc3csyh	653	29	-	-	HYPH
cord-270892-ycc3csyh	653	30	smelling	smell	VBG
cord-270892-ycc3csyh	653	31	Ferula	Ferula	NNP
cord-270892-ycc3csyh	653	32	species	specie	NNS
cord-270892-ycc3csyh	653	33	from	from	IN
cord-270892-ycc3csyh	653	34	the	the	DT
cord-270892-ycc3csyh	653	35	Apiaceae	Apiaceae	NNP
cord-270892-ycc3csyh	653	36	family	family	NN
cord-270892-ycc3csyh	653	37	.	.	.
cord-270892-ycc3csyh	654	1	Based	base	VBN
cord-270892-ycc3csyh	654	2	on	on	IN
cord-270892-ycc3csyh	654	3	the	the	DT
cord-270892-ycc3csyh	654	4	descriptions	description	NNS
cord-270892-ycc3csyh	654	5	given	give	VBN
cord-270892-ycc3csyh	654	6	in	in	IN
cord-270892-ycc3csyh	654	7	the	the	DT
cord-270892-ycc3csyh	654	8	Materia	Materia	NNP
cord-270892-ycc3csyh	654	9	medica	medica	NNP
cord-270892-ycc3csyh	654	10	there	there	EX
cord-270892-ycc3csyh	654	11	is	be	VBZ
cord-270892-ycc3csyh	654	12	strong	strong	JJ
cord-270892-ycc3csyh	654	13	evidence	evidence	NN
cord-270892-ycc3csyh	654	14	that	that	IN
cord-270892-ycc3csyh	654	15	the	the	DT
cord-270892-ycc3csyh	654	16	juice	juice	NN
cord-270892-ycc3csyh	654	17	(	(	-LRB-
cord-270892-ycc3csyh	654	18	i.e.	i.e.	FW
cord-270892-ycc3csyh	654	19	resin	resin	NN
cord-270892-ycc3csyh	654	20	)	)	-RRB-
cord-270892-ycc3csyh	654	21	of	of	IN
cord-270892-ycc3csyh	654	22	the	the	DT
cord-270892-ycc3csyh	654	23	popular	popular	JJ
cord-270892-ycc3csyh	654	24	ancient	ancient	JJ
cord-270892-ycc3csyh	654	25	silphion	silphion	NN
cord-270892-ycc3csyh	654	26	originating	originate	VBG
cord-270892-ycc3csyh	654	27	from	from	IN
cord-270892-ycc3csyh	654	28	Media	Media	NNP
cord-270892-ycc3csyh	654	29	and	and	CC
cord-270892-ycc3csyh	654	30	Syria	Syria	NNP
cord-270892-ycc3csyh	654	31	corresponds	correspond	VBZ
cord-270892-ycc3csyh	654	32	to	to	IN
cord-270892-ycc3csyh	654	33	asafetida	asafetida	NNP
cord-270892-ycc3csyh	654	34	(	(	-LRB-
cord-270892-ycc3csyh	654	35	book	book	NN
cord-270892-ycc3csyh	654	36	III	III	NNP
cord-270892-ycc3csyh	654	37	,	,	,
cord-270892-ycc3csyh	654	38	cap	cap	NN
cord-270892-ycc3csyh	654	39	.	.	.
cord-270892-ycc3csyh	655	1	80	80	LS
cord-270892-ycc3csyh	655	2	)	)	-RRB-
cord-270892-ycc3csyh	655	3	.	.	.
cord-270892-ycc3csyh	656	1	315	315	CD
cord-270892-ycc3csyh	656	2	Yielded	yield	VBN
cord-270892-ycc3csyh	656	3	by	by	IN
cord-270892-ycc3csyh	656	4	incision	incision	NN
cord-270892-ycc3csyh	656	5	of	of	IN
cord-270892-ycc3csyh	656	6	the	the	DT
cord-270892-ycc3csyh	656	7	root	root	NN
cord-270892-ycc3csyh	656	8	and	and	CC
cord-270892-ycc3csyh	656	9	stalk	stalk	VB
cord-270892-ycc3csyh	656	10	and	and	CC
cord-270892-ycc3csyh	656	11	frequently	frequently	RB
cord-270892-ycc3csyh	656	12	mixed	mix	VBN
cord-270892-ycc3csyh	656	13	with	with	IN
cord-270892-ycc3csyh	656	14	sagapenon	sagapenon	NNP
cord-270892-ycc3csyh	656	15	,	,	,
cord-270892-ycc3csyh	656	16	i.e.	i.e.	FW
cord-270892-ycc3csyh	656	17	the	the	DT
cord-270892-ycc3csyh	656	18	resin	resin	NN
cord-270892-ycc3csyh	656	19	of	of	IN
cord-270892-ycc3csyh	656	20	F.	F.	NNP
cord-270892-ycc3csyh	656	21	persica	persica	NN
cord-270892-ycc3csyh	656	22	Willd	Willd	NNP
cord-270892-ycc3csyh	656	23	(	(	-LRB-
cord-270892-ycc3csyh	656	24	book	book	NN
cord-270892-ycc3csyh	656	25	III	III	NNP
cord-270892-ycc3csyh	656	26	,	,	,
cord-270892-ycc3csyh	656	27	cap	cap	NN
cord-270892-ycc3csyh	656	28	.	.	.
cord-270892-ycc3csyh	657	1	81	81	LS
cord-270892-ycc3csyh	657	2	)	)	-RRB-
cord-270892-ycc3csyh	657	3	,	,	,
cord-270892-ycc3csyh	657	4	it	-PRON-	PRP
cord-270892-ycc3csyh	657	5	is	be	VBZ
cord-270892-ycc3csyh	657	6	reported	report	VBN
cord-270892-ycc3csyh	657	7	to	to	TO
cord-270892-ycc3csyh	657	8	be	be	VB
cord-270892-ycc3csyh	657	9	effective	effective	JJ
cord-270892-ycc3csyh	657	10	in	in	IN
cord-270892-ycc3csyh	657	11	the	the	DT
cord-270892-ycc3csyh	657	12	context	context	NN
cord-270892-ycc3csyh	657	13	of	of	IN
cord-270892-ycc3csyh	657	14	upper	upper	JJ
cord-270892-ycc3csyh	657	15	respiratory	respiratory	JJ
cord-270892-ycc3csyh	657	16	diseases	disease	NNS
cord-270892-ycc3csyh	657	17	,	,	,
cord-270892-ycc3csyh	657	18	e.g.	e.g.	RB
cord-270892-ycc3csyh	657	19	'	'	''
cord-270892-ycc3csyh	657	20	'	'	''
cord-270892-ycc3csyh	657	21	for	for	IN
cord-270892-ycc3csyh	657	22	chronic	chronic	JJ
cord-270892-ycc3csyh	657	23	harshness	harshness	NN
cord-270892-ycc3csyh	657	24	of	of	IN
cord-270892-ycc3csyh	657	25	the	the	DT
cord-270892-ycc3csyh	657	26	throat	throat	NN
cord-270892-ycc3csyh	657	27	,	,	,
cord-270892-ycc3csyh	657	28	'	'	''
cord-270892-ycc3csyh	657	29	'	'	''
cord-270892-ycc3csyh	657	30	''	''	''
cord-270892-ycc3csyh	658	1	it	-PRON-	PRP
cord-270892-ycc3csyh	658	2	clears	clear	VBZ
cord-270892-ycc3csyh	658	3	the	the	DT
cord-270892-ycc3csyh	658	4	voice	voice	NN
cord-270892-ycc3csyh	658	5	,	,	,
cord-270892-ycc3csyh	658	6	'	'	''
cord-270892-ycc3csyh	658	7	'	'	''
cord-270892-ycc3csyh	658	8	'	'	''
cord-270892-ycc3csyh	658	9	'	'	''
cord-270892-ycc3csyh	658	10	shrinks	shrink	VBZ
cord-270892-ycc3csyh	658	11	the	the	DT
cord-270892-ycc3csyh	658	12	uvulas	uvula	NNS
cord-270892-ycc3csyh	658	13	,	,	,
cord-270892-ycc3csyh	658	14	'	'	''
cord-270892-ycc3csyh	658	15	'	'	''
cord-270892-ycc3csyh	658	16	'	'	''
cord-270892-ycc3csyh	658	17	'	'	''
cord-270892-ycc3csyh	658	18	suitable	suitable	JJ
cord-270892-ycc3csyh	658	19	for	for	IN
cord-270892-ycc3csyh	658	20	a	a	DT
cord-270892-ycc3csyh	658	21	cough	cough	NN
cord-270892-ycc3csyh	658	22	,	,	,
cord-270892-ycc3csyh	658	23	'	'	''
cord-270892-ycc3csyh	658	24	'	'	''
cord-270892-ycc3csyh	658	25	'	'	''
cord-270892-ycc3csyh	658	26	'	'	''
cord-270892-ycc3csyh	658	27	for	for	IN
cord-270892-ycc3csyh	658	28	pleurisy	pleurisy	NN
cord-270892-ycc3csyh	658	29	,	,	,
cord-270892-ycc3csyh	658	30	'	'	''
cord-270892-ycc3csyh	658	31	'	'	''
cord-270892-ycc3csyh	658	32	'	'	''
cord-270892-ycc3csyh	658	33	'	'	''
cord-270892-ycc3csyh	658	34	for	for	IN
cord-270892-ycc3csyh	658	35	chest	chest	NN
cord-270892-ycc3csyh	658	36	pain	pain	NN
cord-270892-ycc3csyh	658	37	;	;	:
cord-270892-ycc3csyh	658	38	'	'	''
cord-270892-ycc3csyh	658	39	'	'	''
cord-270892-ycc3csyh	658	40	sagapenon	sagapenon	NNP
cord-270892-ycc3csyh	658	41	is	be	VBZ
cord-270892-ycc3csyh	658	42	described	describe	VBN
cord-270892-ycc3csyh	658	43	as	as	IN
cord-270892-ycc3csyh	658	44	follows	follow	VBZ
cord-270892-ycc3csyh	658	45	:	:	:
cord-270892-ycc3csyh	658	46	'	'	``
cord-270892-ycc3csyh	658	47	'	'	''
cord-270892-ycc3csyh	658	48	it	-PRON-	PRP
cord-270892-ycc3csyh	658	49	clears	clear	VBZ
cord-270892-ycc3csyh	658	50	thick	thick	JJ
cord-270892-ycc3csyh	658	51	matters	matter	NNS
cord-270892-ycc3csyh	658	52	from	from	IN
cord-270892-ycc3csyh	658	53	the	the	DT
cord-270892-ycc3csyh	658	54	lungs	lung	NNS
cord-270892-ycc3csyh	658	55	,	,	,
cord-270892-ycc3csyh	658	56	'	'	''
cord-270892-ycc3csyh	658	57	'	'	''
cord-270892-ycc3csyh	658	58	'	'	''
cord-270892-ycc3csyh	658	59	'	'	''
cord-270892-ycc3csyh	658	60	given	give	VBN
cord-270892-ycc3csyh	658	61	to	to	IN
cord-270892-ycc3csyh	658	62	those	those	DT
cord-270892-ycc3csyh	658	63	who	who	WP
cord-270892-ycc3csyh	658	64	are	be	VBP
cord-270892-ycc3csyh	658	65	chilled	chill	VBN
cord-270892-ycc3csyh	658	66	.	.	.
cord-270892-ycc3csyh	658	67	'	'	''
cord-270892-ycc3csyh	658	68	'	'	''
cord-270892-ycc3csyh	659	1	315	315	CD
cord-270892-ycc3csyh	660	1	These	these	DT
cord-270892-ycc3csyh	660	2	descriptions	description	NNS
cord-270892-ycc3csyh	660	3	finally	finally	RB
cord-270892-ycc3csyh	660	4	helped	help	VBD
cord-270892-ycc3csyh	660	5	to	to	TO
cord-270892-ycc3csyh	660	6	prioritize	prioritize	VB
cord-270892-ycc3csyh	660	7	those	those	DT
cord-270892-ycc3csyh	660	8	virtual	virtual	JJ
cord-270892-ycc3csyh	660	9	hits	hit	NNS
cord-270892-ycc3csyh	660	10	,	,	,
cord-270892-ycc3csyh	660	11	which	which	WDT
cord-270892-ycc3csyh	660	12	have	have	VBP
cord-270892-ycc3csyh	660	13	been	be	VBN
cord-270892-ycc3csyh	660	14	reported	report	VBN
cord-270892-ycc3csyh	660	15	to	to	TO
cord-270892-ycc3csyh	660	16	be	be	VB
cord-270892-ycc3csyh	660	17	constituents	constituent	NNS
cord-270892-ycc3csyh	660	18	of	of	IN
cord-270892-ycc3csyh	660	19	asafetida	asafetida	NNP
cord-270892-ycc3csyh	660	20	.	.	.
cord-270892-ycc3csyh	661	1	316	316	CD
cord-270892-ycc3csyh	662	1	The	the	DT
cord-270892-ycc3csyh	662	2	pharmacological	pharmacological	JJ
cord-270892-ycc3csyh	662	3	investigation	investigation	NN
cord-270892-ycc3csyh	662	4	of	of	IN
cord-270892-ycc3csyh	662	5	asafetida	asafetida	NNP
cord-270892-ycc3csyh	662	6	and	and	CC
cord-270892-ycc3csyh	662	7	its	-PRON-	PRP$
cord-270892-ycc3csyh	662	8	constituents	constituent	NNS
cord-270892-ycc3csyh	662	9	farnesiferol	farnesiferol	NNP
cord-270892-ycc3csyh	662	10	B	B	NNP
cord-270892-ycc3csyh	662	11	and	and	CC
cord-270892-ycc3csyh	662	12	C	C	NNP
cord-270892-ycc3csyh	663	1	(	(	-LRB-
cord-270892-ycc3csyh	663	2	Fig	Fig	NNP
cord-270892-ycc3csyh	663	3	.	.	.
cord-270892-ycc3csyh	664	1	5	5	LS
cord-270892-ycc3csyh	664	2	;	;	:
cord-270892-ycc3csyh	664	3	Table	Table	NNP
cord-270892-ycc3csyh	664	4	III	III	NNP
cord-270892-ycc3csyh	664	5	)	)	-RRB-
cord-270892-ycc3csyh	664	6	revealed	reveal	VBD
cord-270892-ycc3csyh	664	7	a	a	DT
cord-270892-ycc3csyh	664	8	distinct	distinct	JJ
cord-270892-ycc3csyh	664	9	anti	anti	NN
cord-270892-ycc3csyh	664	10	-	-	NN
cord-270892-ycc3csyh	664	11	HRV-2	hrv-2	JJ
cord-270892-ycc3csyh	664	12	effect	effect	NN
cord-270892-ycc3csyh	664	13	in	in	IN
cord-270892-ycc3csyh	664	14	the	the	DT
cord-270892-ycc3csyh	664	15	low	low	JJ
cord-270892-ycc3csyh	664	16	micromolar	micromolar	JJ
cord-270892-ycc3csyh	664	17	range	range	NN
cord-270892-ycc3csyh	664	18	using	use	VBG
cord-270892-ycc3csyh	664	19	a	a	DT
cord-270892-ycc3csyh	664	20	CPE	CPE	NNP
cord-270892-ycc3csyh	664	21	inhibitory	inhibitory	JJ
cord-270892-ycc3csyh	664	22	assay	assay	NN
cord-270892-ycc3csyh	664	23	.	.	.
cord-270892-ycc3csyh	665	1	143	143	CD
cord-270892-ycc3csyh	666	1	The	the	DT
cord-270892-ycc3csyh	666	2	results	result	NNS
cord-270892-ycc3csyh	666	3	of	of	IN
cord-270892-ycc3csyh	666	4	this	this	DT
cord-270892-ycc3csyh	666	5	study	study	NN
cord-270892-ycc3csyh	666	6	provided	provide	VBD
cord-270892-ycc3csyh	666	7	a	a	DT
cord-270892-ycc3csyh	666	8	rationale	rationale	NN
cord-270892-ycc3csyh	666	9	for	for	IN
cord-270892-ycc3csyh	666	10	the	the	DT
cord-270892-ycc3csyh	666	11	ancient	ancient	JJ
cord-270892-ycc3csyh	666	12	usage	usage	NN
cord-270892-ycc3csyh	666	13	of	of	IN
cord-270892-ycc3csyh	666	14	asafetida	asafetida	NNP
cord-270892-ycc3csyh	666	15	for	for	IN
cord-270892-ycc3csyh	666	16	upper	upper	JJ
cord-270892-ycc3csyh	666	17	respiratory	respiratory	JJ
cord-270892-ycc3csyh	666	18	tract	tract	NN
cord-270892-ycc3csyh	666	19	infections	infection	NNS
cord-270892-ycc3csyh	666	20	.	.	.
cord-270892-ycc3csyh	667	1	On	on	IN
cord-270892-ycc3csyh	667	2	the	the	DT
cord-270892-ycc3csyh	667	3	other	other	JJ
cord-270892-ycc3csyh	667	4	hand	hand	NN
cord-270892-ycc3csyh	667	5	,	,	,
cord-270892-ycc3csyh	667	6	the	the	DT
cord-270892-ycc3csyh	667	7	traditionally	traditionally	RB
cord-270892-ycc3csyh	667	8	manifested	manifest	VBN
cord-270892-ycc3csyh	667	9	evidence	evidence	NN
cord-270892-ycc3csyh	667	10	for	for	IN
cord-270892-ycc3csyh	667	11	asafetida	asafetida	NNP
cord-270892-ycc3csyh	667	12	for	for	IN
cord-270892-ycc3csyh	667	13	the	the	DT
cord-270892-ycc3csyh	667	14	treatment	treatment	NN
cord-270892-ycc3csyh	667	15	of	of	IN
cord-270892-ycc3csyh	667	16	common	common	JJ
cord-270892-ycc3csyh	667	17	cold	cold	JJ
cord-270892-ycc3csyh	667	18	symptoms	symptom	NNS
cord-270892-ycc3csyh	667	19	substantially	substantially	RB
cord-270892-ycc3csyh	667	20	helped	help	VBD
cord-270892-ycc3csyh	667	21	in	in	IN
cord-270892-ycc3csyh	667	22	the	the	DT
cord-270892-ycc3csyh	667	23	selection	selection	NN
cord-270892-ycc3csyh	667	24	of	of	IN
cord-270892-ycc3csyh	667	25	this	this	DT
cord-270892-ycc3csyh	667	26	plant	plant	NN
cord-270892-ycc3csyh	667	27	material	material	NN
cord-270892-ycc3csyh	667	28	in	in	IN
cord-270892-ycc3csyh	667	29	the	the	DT
cord-270892-ycc3csyh	667	30	search	search	NN
cord-270892-ycc3csyh	667	31	for	for	IN
cord-270892-ycc3csyh	667	32	anti	anti	JJ
cord-270892-ycc3csyh	667	33	-	-	JJ
cord-270892-ycc3csyh	667	34	HRV	HRV	NNP
cord-270892-ycc3csyh	667	35	capsid	capsid	NN
cord-270892-ycc3csyh	667	36	binders	binder	NNS
cord-270892-ycc3csyh	667	37	.	.	.
cord-270892-ycc3csyh	668	1	144	144	CD
cord-270892-ycc3csyh	669	1	Typically	typically	RB
cord-270892-ycc3csyh	669	2	,	,	,
cord-270892-ycc3csyh	669	3	an	an	DT
cord-270892-ycc3csyh	669	4	ethnopharmacologically	ethnopharmacologically	RB
cord-270892-ycc3csyh	669	5	based	base	VBN
cord-270892-ycc3csyh	669	6	discovery	discovery	NN
cord-270892-ycc3csyh	669	7	of	of	IN
cord-270892-ycc3csyh	669	8	an	an	DT
cord-270892-ycc3csyh	669	9	active	active	JJ
cord-270892-ycc3csyh	669	10	(	(	-LRB-
cord-270892-ycc3csyh	669	11	anti	anti	JJ
cord-270892-ycc3csyh	669	12	-	-	JJ
cord-270892-ycc3csyh	669	13	HRV	HRV	NNP
cord-270892-ycc3csyh	669	14	)	)	-RRB-
cord-270892-ycc3csyh	669	15	extract	extract	NN
cord-270892-ycc3csyh	669	16	is	be	VBZ
cord-270892-ycc3csyh	669	17	followed	follow	VBN
cord-270892-ycc3csyh	669	18	by	by	IN
cord-270892-ycc3csyh	669	19	a	a	DT
cord-270892-ycc3csyh	669	20	bioassay	bioassay	NN
cord-270892-ycc3csyh	669	21	guided	guide	VBN
cord-270892-ycc3csyh	669	22	fractionation	fractionation	NN
cord-270892-ycc3csyh	669	23	,	,	,
cord-270892-ycc3csyh	669	24	and	and	CC
cord-270892-ycc3csyh	669	25	the	the	DT
cord-270892-ycc3csyh	669	26	isolation	isolation	NN
cord-270892-ycc3csyh	669	27	of	of	IN
cord-270892-ycc3csyh	669	28	those	those	DT
cord-270892-ycc3csyh	669	29	constituents	constituent	NNS
cord-270892-ycc3csyh	669	30	that	that	WDT
cord-270892-ycc3csyh	669	31	are	be	VBP
cord-270892-ycc3csyh	669	32	responsible	responsible	JJ
cord-270892-ycc3csyh	669	33	for	for	IN
cord-270892-ycc3csyh	669	34	the	the	DT
cord-270892-ycc3csyh	669	35	extracts	extract	NNS
cord-270892-ycc3csyh	669	36	'	'	POS
cord-270892-ycc3csyh	669	37	bioactivity	bioactivity	NN
cord-270892-ycc3csyh	669	38	.	.	.
cord-270892-ycc3csyh	670	1	The	the	DT
cord-270892-ycc3csyh	670	2	concept	concept	NN
cord-270892-ycc3csyh	670	3	of	of	IN
cord-270892-ycc3csyh	670	4	a	a	DT
cord-270892-ycc3csyh	670	5	bioassay	bioassay	NN
cord-270892-ycc3csyh	670	6	-	-	HYPH
cord-270892-ycc3csyh	670	7	guided	guide	VBN
cord-270892-ycc3csyh	670	8	approach	approach	NN
cord-270892-ycc3csyh	670	9	is	be	VBZ
cord-270892-ycc3csyh	670	10	the	the	DT
cord-270892-ycc3csyh	670	11	fractionation	fractionation	NN
cord-270892-ycc3csyh	670	12	accompanied	accompany	VBN
cord-270892-ycc3csyh	670	13	by	by	IN
cord-270892-ycc3csyh	670	14	simultaneous	simultaneous	JJ
cord-270892-ycc3csyh	670	15	detection	detection	NN
cord-270892-ycc3csyh	670	16	of	of	IN
cord-270892-ycc3csyh	670	17	the	the	DT
cord-270892-ycc3csyh	670	18	activity	activity	NN
cord-270892-ycc3csyh	670	19	during	during	IN
cord-270892-ycc3csyh	670	20	the	the	DT
cord-270892-ycc3csyh	670	21	separation	separation	NN
cord-270892-ycc3csyh	670	22	steps	step	NNS
cord-270892-ycc3csyh	670	23	,	,	,
cord-270892-ycc3csyh	670	24	which	which	WDT
cord-270892-ycc3csyh	670	25	results	result	VBZ
cord-270892-ycc3csyh	670	26	in	in	IN
cord-270892-ycc3csyh	670	27	a	a	DT
cord-270892-ycc3csyh	670	28	continuous	continuous	JJ
cord-270892-ycc3csyh	670	29	enrichment	enrichment	NN
cord-270892-ycc3csyh	670	30	,	,	,
cord-270892-ycc3csyh	670	31	and	and	CC
cord-270892-ycc3csyh	670	32	finally	finally	RB
cord-270892-ycc3csyh	670	33	in	in	IN
cord-270892-ycc3csyh	670	34	the	the	DT
cord-270892-ycc3csyh	670	35	isolation	isolation	NN
cord-270892-ycc3csyh	670	36	of	of	IN
cord-270892-ycc3csyh	670	37	the	the	DT
cord-270892-ycc3csyh	670	38	active	active	JJ
cord-270892-ycc3csyh	670	39	ingredient	ingredient	NN
cord-270892-ycc3csyh	670	40	/	/	SYM
cord-270892-ycc3csyh	670	41	s	s	NN
cord-270892-ycc3csyh	670	42	.	.	.
cord-270892-ycc3csyh	671	1	In	in	IN
cord-270892-ycc3csyh	671	2	this	this	DT
cord-270892-ycc3csyh	671	3	way	way	NN
cord-270892-ycc3csyh	671	4	a	a	DT
cord-270892-ycc3csyh	671	5	large	large	JJ
cord-270892-ycc3csyh	671	6	number	number	NN
cord-270892-ycc3csyh	671	7	of	of	IN
cord-270892-ycc3csyh	671	8	anti	anti	JJ
cord-270892-ycc3csyh	671	9	-	-	JJ
cord-270892-ycc3csyh	671	10	HRV	HRV	NNP
cord-270892-ycc3csyh	671	11	agents	agent	NNS
cord-270892-ycc3csyh	671	12	from	from	IN
cord-270892-ycc3csyh	671	13	natural	natural	JJ
cord-270892-ycc3csyh	671	14	sources	source	NNS
cord-270892-ycc3csyh	671	15	have	have	VBP
cord-270892-ycc3csyh	671	16	already	already	RB
cord-270892-ycc3csyh	671	17	been	be	VBN
cord-270892-ycc3csyh	671	18	discovered	discover	VBN
cord-270892-ycc3csyh	671	19	.	.	.
cord-270892-ycc3csyh	672	1	Semple	Semple	NNP
cord-270892-ycc3csyh	672	2	et	et	NNP
cord-270892-ycc3csyh	672	3	al	al	NNP
cord-270892-ycc3csyh	672	4	.	.	NNP
cord-270892-ycc3csyh	672	5	investigated	investigate	VBD
cord-270892-ycc3csyh	672	6	the	the	DT
cord-270892-ycc3csyh	672	7	active	active	JJ
cord-270892-ycc3csyh	672	8	principle	principle	NN
cord-270892-ycc3csyh	672	9	of	of	IN
cord-270892-ycc3csyh	672	10	the	the	DT
cord-270892-ycc3csyh	672	11	Asteraceae	Asteraceae	NNP
cord-270892-ycc3csyh	672	12	plant	plant	NN
cord-270892-ycc3csyh	672	13	Pterocaulon	Pterocaulon	NNP
cord-270892-ycc3csyh	672	14	sphacelatum	sphacelatum	NNP
cord-270892-ycc3csyh	672	15	,	,	,
cord-270892-ycc3csyh	672	16	which	which	WDT
cord-270892-ycc3csyh	672	17	has	have	VBZ
cord-270892-ycc3csyh	672	18	been	be	VBN
cord-270892-ycc3csyh	672	19	used	use	VBN
cord-270892-ycc3csyh	672	20	in	in	IN
cord-270892-ycc3csyh	672	21	traditional	traditional	JJ
cord-270892-ycc3csyh	672	22	medicine	medicine	NN
cord-270892-ycc3csyh	672	23	of	of	IN
cord-270892-ycc3csyh	672	24	Aboriginal	aboriginal	JJ
cord-270892-ycc3csyh	672	25	people	people	NNS
cord-270892-ycc3csyh	672	26	of	of	IN
cord-270892-ycc3csyh	672	27	Australia	Australia	NNP
cord-270892-ycc3csyh	672	28	as	as	IN
cord-270892-ycc3csyh	672	29	a	a	DT
cord-270892-ycc3csyh	672	30	favored	favor	VBN
cord-270892-ycc3csyh	672	31	treatment	treatment	NN
cord-270892-ycc3csyh	672	32	for	for	IN
cord-270892-ycc3csyh	672	33	respiratory	respiratory	JJ
cord-270892-ycc3csyh	672	34	infections	infection	NNS
cord-270892-ycc3csyh	672	35	,	,	,
cord-270892-ycc3csyh	672	36	especially	especially	RB
cord-270892-ycc3csyh	672	37	colds	cold	NNS
cord-270892-ycc3csyh	672	38	.	.	.
cord-270892-ycc3csyh	673	1	By	by	IN
cord-270892-ycc3csyh	673	2	means	mean	NNS
cord-270892-ycc3csyh	673	3	of	of	IN
cord-270892-ycc3csyh	673	4	an	an	DT
cord-270892-ycc3csyh	673	5	antiviral	antiviral	JJ
cord-270892-ycc3csyh	673	6	activity	activity	NN
cord-270892-ycc3csyh	673	7	-	-	HYPH
cord-270892-ycc3csyh	673	8	guided	guide	VBN
cord-270892-ycc3csyh	673	9	fractionation	fractionation	NN
cord-270892-ycc3csyh	673	10	measuring	measure	VBG
cord-270892-ycc3csyh	673	11	the	the	DT
cord-270892-ycc3csyh	673	12	poliovirus	poliovirus	NN
cord-270892-ycc3csyh	673	13	-	-	HYPH
cord-270892-ycc3csyh	673	14	induced	induce	VBN
cord-270892-ycc3csyh	673	15	CPE	CPE	NNP
cord-270892-ycc3csyh	673	16	assay	assay	NN
cord-270892-ycc3csyh	673	17	,	,	,
cord-270892-ycc3csyh	673	18	the	the	DT
cord-270892-ycc3csyh	673	19	authors	author	NNS
cord-270892-ycc3csyh	673	20	identified	identify	VBD
cord-270892-ycc3csyh	673	21	the	the	DT
cord-270892-ycc3csyh	673	22	flavonoid	flavonoid	NN
cord-270892-ycc3csyh	673	23	3,7,3	3,7,3	CD
cord-270892-ycc3csyh	673	24	0	0	CD
cord-270892-ycc3csyh	673	25	-trimethoxy-5,6,4	-trimethoxy-5,6,4	CD
cord-270892-ycc3csyh	673	26	0	0	CD
cord-270892-ycc3csyh	673	27	-trihydroxyflavone	-trihydroxyflavone	CD
cord-270892-ycc3csyh	673	28	,	,	,
cord-270892-ycc3csyh	673	29	i.e.	i.e.	FW
cord-270892-ycc3csyh	673	30	chrysosplenol	chrysosplenol	NN
cord-270892-ycc3csyh	673	31	C	C	NNP
cord-270892-ycc3csyh	673	32	(	(	-LRB-
cord-270892-ycc3csyh	673	33	Fig	Fig	NNP
cord-270892-ycc3csyh	673	34	.	.	NNP
cord-270892-ycc3csyh	673	35	5	5	CD
cord-270892-ycc3csyh	673	36	;	;	:
cord-270892-ycc3csyh	673	37	Table	Table	NNP
cord-270892-ycc3csyh	673	38	III	III	NNP
cord-270892-ycc3csyh	673	39	)	)	-RRB-
cord-270892-ycc3csyh	673	40	as	as	RB
cord-270892-ycc3csyh	673	41	potent	potent	JJ
cord-270892-ycc3csyh	673	42	and	and	CC
cord-270892-ycc3csyh	673	43	specific	specific	JJ
cord-270892-ycc3csyh	673	44	inhibitor	inhibitor	NN
cord-270892-ycc3csyh	673	45	of	of	IN
cord-270892-ycc3csyh	673	46	the	the	DT
cord-270892-ycc3csyh	673	47	picornaviral	picornaviral	JJ
cord-270892-ycc3csyh	673	48	replication	replication	NN
cord-270892-ycc3csyh	673	49	.	.	.
cord-270892-ycc3csyh	674	1	6,7,8-Trimethoxycoumarin	6,7,8-trimethoxycoumarin	CD
cord-270892-ycc3csyh	675	1	(	(	-LRB-
cord-270892-ycc3csyh	675	2	Fig	Fig	NNP
cord-270892-ycc3csyh	675	3	.	.	.
cord-270892-ycc3csyh	676	1	5	5	LS
cord-270892-ycc3csyh	676	2	;	;	:
cord-270892-ycc3csyh	676	3	Table	Table	NNP
cord-270892-ycc3csyh	676	4	III	III	NNP
cord-270892-ycc3csyh	676	5	)	)	-RRB-
cord-270892-ycc3csyh	676	6	was	be	VBD
cord-270892-ycc3csyh	676	7	also	also	RB
cord-270892-ycc3csyh	676	8	isolated	isolate	VBN
cord-270892-ycc3csyh	676	9	as	as	IN
cord-270892-ycc3csyh	676	10	a	a	DT
cord-270892-ycc3csyh	676	11	major	major	JJ
cord-270892-ycc3csyh	676	12	constituent	constituent	NN
cord-270892-ycc3csyh	676	13	from	from	IN
cord-270892-ycc3csyh	676	14	the	the	DT
cord-270892-ycc3csyh	676	15	ethanolic	ethanolic	JJ
cord-270892-ycc3csyh	676	16	extract	extract	NN
cord-270892-ycc3csyh	676	17	of	of	IN
cord-270892-ycc3csyh	676	18	P.	P.	NNP
cord-270892-ycc3csyh	676	19	sphacelatum	sphacelatum	NNP
cord-270892-ycc3csyh	676	20	,	,	,
cord-270892-ycc3csyh	676	21	but	but	CC
cord-270892-ycc3csyh	676	22	showed	show	VBD
cord-270892-ycc3csyh	676	23	no	no	DT
cord-270892-ycc3csyh	676	24	activity	activity	NN
cord-270892-ycc3csyh	676	25	against	against	IN
cord-270892-ycc3csyh	676	26	poliovirus	poliovirus	NN
cord-270892-ycc3csyh	676	27	.	.	.
cord-270892-ycc3csyh	677	1	317	317	CD
cord-270892-ycc3csyh	678	1	Interestingly	interestingly	RB
cord-270892-ycc3csyh	678	2	,	,	,
cord-270892-ycc3csyh	678	3	this	this	DT
cord-270892-ycc3csyh	678	4	coumarin	coumarin	NN
cord-270892-ycc3csyh	678	5	exhibited	exhibit	VBD
cord-270892-ycc3csyh	678	6	a	a	DT
cord-270892-ycc3csyh	678	7	significant	significant	JJ
cord-270892-ycc3csyh	678	8	effect	effect	NN
cord-270892-ycc3csyh	678	9	in	in	IN
cord-270892-ycc3csyh	678	10	the	the	DT
cord-270892-ycc3csyh	678	11	HRV-2-induced	hrv-2-induce	VBN
cord-270892-ycc3csyh	678	12	CPE	CPE	NNP
cord-270892-ycc3csyh	678	13	assay	assay	NN
cord-270892-ycc3csyh	678	14	in	in	IN
cord-270892-ycc3csyh	678	15	a	a	DT
cord-270892-ycc3csyh	678	16	recently	recently	RB
cord-270892-ycc3csyh	678	17	performed	perform	VBN
cord-270892-ycc3csyh	678	18	virtual	virtual	JJ
cord-270892-ycc3csyh	678	19	parallel	parallel	JJ
cord-270892-ycc3csyh	678	20	screening	screening	NN
cord-270892-ycc3csyh	678	21	study	study	NN
cord-270892-ycc3csyh	678	22	performed	perform	VBN
cord-270892-ycc3csyh	678	23	in	in	IN
cord-270892-ycc3csyh	678	24	our	-PRON-	PRP$
cord-270892-ycc3csyh	678	25	laboratory	laboratory	NN
cord-270892-ycc3csyh	678	26	.	.	.
cord-270892-ycc3csyh	679	1	318	318	CD
cord-270892-ycc3csyh	680	1	In	in	IN
cord-270892-ycc3csyh	680	2	contrast	contrast	NN
cord-270892-ycc3csyh	680	3	to	to	IN
cord-270892-ycc3csyh	680	4	the	the	DT
cord-270892-ycc3csyh	680	5	isolated	isolate	VBN
cord-270892-ycc3csyh	680	6	coumarin	coumarin	NN
cord-270892-ycc3csyh	680	7	,	,	,
cord-270892-ycc3csyh	680	8	chrysosplenol	chrysosplenol	NNP
cord-270892-ycc3csyh	680	9	C	C	NNP
cord-270892-ycc3csyh	680	10	was	be	VBD
cord-270892-ycc3csyh	680	11	already	already	RB
cord-270892-ycc3csyh	680	12	known	know	VBN
cord-270892-ycc3csyh	680	13	as	as	IN
cord-270892-ycc3csyh	680	14	a	a	DT
cord-270892-ycc3csyh	680	15	member	member	NN
cord-270892-ycc3csyh	680	16	of	of	IN
cord-270892-ycc3csyh	680	17	the	the	DT
cord-270892-ycc3csyh	680	18	4	4	CD
cord-270892-ycc3csyh	680	19	0	0	CD
cord-270892-ycc3csyh	680	20	-hydroxy-3-methoxyflavones	-hydroxy-3-methoxyflavones	CD
cord-270892-ycc3csyh	680	21	,	,	,
cord-270892-ycc3csyh	680	22	which	which	WDT
cord-270892-ycc3csyh	680	23	represent	represent	VBP
cord-270892-ycc3csyh	680	24	potent	potent	JJ
cord-270892-ycc3csyh	680	25	and	and	CC
cord-270892-ycc3csyh	680	26	specific	specific	JJ
cord-270892-ycc3csyh	680	27	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	680	28	of	of	IN
cord-270892-ycc3csyh	680	29	picornaviral	picornaviral	NN
cord-270892-ycc3csyh	680	30	,	,	,
cord-270892-ycc3csyh	680	31	especially	especially	RB
cord-270892-ycc3csyh	680	32	rhinoviral	rhinoviral	JJ
cord-270892-ycc3csyh	680	33	replication	replication	NN
cord-270892-ycc3csyh	680	34	.	.	.
cord-270892-ycc3csyh	681	1	[	[	-LRB-
cord-270892-ycc3csyh	681	2	319	319	CD
cord-270892-ycc3csyh	681	3	]	]	-RRB-
cord-270892-ycc3csyh	681	4	[	[	-LRB-
cord-270892-ycc3csyh	681	5	320	320	CD
cord-270892-ycc3csyh	681	6	]	]	-RRB-
cord-270892-ycc3csyh	682	1	[	[	-LRB-
cord-270892-ycc3csyh	682	2	321	321	CD
cord-270892-ycc3csyh	682	3	]	]	-RRB-
cord-270892-ycc3csyh	683	1	In	in	IN
cord-270892-ycc3csyh	683	2	1993	1993	CD
cord-270892-ycc3csyh	683	3	,	,	,
cord-270892-ycc3csyh	683	4	Vanden	Vanden	NNP
cord-270892-ycc3csyh	683	5	Berghe	Berghe	NNP
cord-270892-ycc3csyh	683	6	,	,	,
cord-270892-ycc3csyh	683	7	Haemers	Haemers	NNP
cord-270892-ycc3csyh	683	8	,	,	,
cord-270892-ycc3csyh	683	9	and	and	CC
cord-270892-ycc3csyh	683	10	Vlietinck	Vlietinck	NNP
cord-270892-ycc3csyh	683	11	provided	provide	VBD
cord-270892-ycc3csyh	683	12	a	a	DT
cord-270892-ycc3csyh	683	13	profound	profound	JJ
cord-270892-ycc3csyh	683	14	survey	survey	NN
cord-270892-ycc3csyh	683	15	of	of	IN
cord-270892-ycc3csyh	683	16	antiviral	antiviral	JJ
cord-270892-ycc3csyh	683	17	agents	agent	NNS
cord-270892-ycc3csyh	683	18	from	from	IN
cord-270892-ycc3csyh	683	19	higher	high	JJR
cord-270892-ycc3csyh	683	20	plants	plant	NNS
cord-270892-ycc3csyh	683	21	,	,	,
cord-270892-ycc3csyh	683	22	and	and	CC
cord-270892-ycc3csyh	683	23	demonstrated	demonstrate	VBD
cord-270892-ycc3csyh	683	24	the	the	DT
cord-270892-ycc3csyh	683	25	impact	impact	NN
cord-270892-ycc3csyh	683	26	of	of	IN
cord-270892-ycc3csyh	683	27	ethnobotanical	ethnobotanical	JJ
cord-270892-ycc3csyh	683	28	knowledge	knowledge	NN
cord-270892-ycc3csyh	683	29	in	in	IN
cord-270892-ycc3csyh	683	30	their	-PRON-	PRP$
cord-270892-ycc3csyh	683	31	search	search	NN
cord-270892-ycc3csyh	683	32	for	for	IN
cord-270892-ycc3csyh	683	33	antiviral	antiviral	JJ
cord-270892-ycc3csyh	683	34	compounds	compound	NNS
cord-270892-ycc3csyh	683	35	from	from	IN
cord-270892-ycc3csyh	683	36	African	african	JJ
cord-270892-ycc3csyh	683	37	medicinal	medicinal	JJ
cord-270892-ycc3csyh	683	38	plants	plant	NNS
cord-270892-ycc3csyh	683	39	.	.	.
cord-270892-ycc3csyh	684	1	The	the	DT
cord-270892-ycc3csyh	684	2	selection	selection	NN
cord-270892-ycc3csyh	684	3	of	of	IN
cord-270892-ycc3csyh	684	4	investigated	investigate	VBN
cord-270892-ycc3csyh	684	5	plant	plant	NN
cord-270892-ycc3csyh	684	6	species	specie	NNS
cord-270892-ycc3csyh	684	7	was	be	VBD
cord-270892-ycc3csyh	684	8	mainly	mainly	RB
cord-270892-ycc3csyh	684	9	based	base	VBN
cord-270892-ycc3csyh	684	10	upon	upon	IN
cord-270892-ycc3csyh	684	11	their	-PRON-	PRP$
cord-270892-ycc3csyh	684	12	use	use	NN
cord-270892-ycc3csyh	684	13	in	in	IN
cord-270892-ycc3csyh	684	14	the	the	DT
cord-270892-ycc3csyh	684	15	treatment	treatment	NN
cord-270892-ycc3csyh	684	16	of	of	IN
cord-270892-ycc3csyh	684	17	viral	viral	JJ
cord-270892-ycc3csyh	684	18	diseases	disease	NNS
cord-270892-ycc3csyh	684	19	by	by	IN
cord-270892-ycc3csyh	684	20	African	african	JJ
cord-270892-ycc3csyh	684	21	traditional	traditional	JJ
cord-270892-ycc3csyh	684	22	healers	healer	NNS
cord-270892-ycc3csyh	684	23	.	.	.
cord-270892-ycc3csyh	685	1	320	320	CD
cord-270892-ycc3csyh	686	1	The	the	DT
cord-270892-ycc3csyh	686	2	antiviral	antiviral	JJ
cord-270892-ycc3csyh	686	3	activity	activity	NN
cord-270892-ycc3csyh	686	4	of	of	IN
cord-270892-ycc3csyh	686	5	100	100	CD
cord-270892-ycc3csyh	686	6	different	different	JJ
cord-270892-ycc3csyh	686	7	plant	plant	NN
cord-270892-ycc3csyh	686	8	species	specie	NNS
cord-270892-ycc3csyh	686	9	belonging	belong	VBG
cord-270892-ycc3csyh	686	10	to	to	IN
cord-270892-ycc3csyh	686	11	33	33	CD
cord-270892-ycc3csyh	686	12	families	family	NNS
cord-270892-ycc3csyh	686	13	was	be	VBD
cord-270892-ycc3csyh	686	14	investigated	investigate	VBN
cord-270892-ycc3csyh	686	15	;	;	:
cord-270892-ycc3csyh	686	16	thereof	thereof	IN
cord-270892-ycc3csyh	686	17	21	21	CD
cord-270892-ycc3csyh	686	18	species	specie	NNS
cord-270892-ycc3csyh	686	19	exhibited	exhibit	VBD
cord-270892-ycc3csyh	686	20	prominent	prominent	JJ
cord-270892-ycc3csyh	686	21	antiviral	antiviral	JJ
cord-270892-ycc3csyh	686	22	properties	property	NNS
cord-270892-ycc3csyh	686	23	against	against	IN
cord-270892-ycc3csyh	686	24	one	one	CD
cord-270892-ycc3csyh	686	25	or	or	CC
cord-270892-ycc3csyh	686	26	more	more	JJR
cord-270892-ycc3csyh	686	27	of	of	IN
cord-270892-ycc3csyh	686	28	the	the	DT
cord-270892-ycc3csyh	686	29	tested	test	VBN
cord-270892-ycc3csyh	686	30	viruses	virus	NNS
cord-270892-ycc3csyh	686	31	.	.	.
cord-270892-ycc3csyh	687	1	The	the	DT
cord-270892-ycc3csyh	687	2	most	most	RBS
cord-270892-ycc3csyh	687	3	pronounced	pronounced	JJ
cord-270892-ycc3csyh	687	4	activity	activity	NN
cord-270892-ycc3csyh	687	5	against	against	IN
cord-270892-ycc3csyh	687	6	picornaviruses	picornavirus	NNS
cord-270892-ycc3csyh	687	7	was	be	VBD
cord-270892-ycc3csyh	687	8	recorded	record	VBN
cord-270892-ycc3csyh	687	9	within	within	IN
cord-270892-ycc3csyh	687	10	the	the	DT
cord-270892-ycc3csyh	687	11	genus	genus	NN
cord-270892-ycc3csyh	687	12	Euphorbia	Euphorbia	NNP
cord-270892-ycc3csyh	687	13	.	.	.
cord-270892-ycc3csyh	688	1	All	all	DT
cord-270892-ycc3csyh	688	2	compounds	compound	NNS
cord-270892-ycc3csyh	688	3	detected	detect	VBN
cord-270892-ycc3csyh	688	4	as	as	IN
cord-270892-ycc3csyh	688	5	antiviral	antiviral	JJ
cord-270892-ycc3csyh	688	6	constituents	constituent	NNS
cord-270892-ycc3csyh	688	7	from	from	IN
cord-270892-ycc3csyh	688	8	the	the	DT
cord-270892-ycc3csyh	688	9	respective	respective	JJ
cord-270892-ycc3csyh	688	10	extracts	extract	NNS
cord-270892-ycc3csyh	688	11	were	be	VBD
cord-270892-ycc3csyh	688	12	identified	identify	VBN
cord-270892-ycc3csyh	688	13	as	as	IN
cord-270892-ycc3csyh	688	14	3-methoxyflavone	3-methoxyflavone	CD
cord-270892-ycc3csyh	688	15	derivatives	derivative	NNS
cord-270892-ycc3csyh	688	16	,	,	,
cord-270892-ycc3csyh	688	17	especially	especially	RB
cord-270892-ycc3csyh	688	18	3-methylethers	3-methylethers	CD
cord-270892-ycc3csyh	688	19	of	of	IN
cord-270892-ycc3csyh	688	20	quercetin	quercetin	NN
cord-270892-ycc3csyh	688	21	and	and	CC
cord-270892-ycc3csyh	688	22	kaempferol	kaempferol	NNP
cord-270892-ycc3csyh	688	23	(	(	-LRB-
cord-270892-ycc3csyh	688	24	Fig	Fig	NNP
cord-270892-ycc3csyh	688	25	.	.	NNP
cord-270892-ycc3csyh	688	26	5	5	CD
cord-270892-ycc3csyh	688	27	;	;	:
cord-270892-ycc3csyh	688	28	Table	Table	NNP
cord-270892-ycc3csyh	688	29	III	III	NNP
cord-270892-ycc3csyh	688	30	)	)	-RRB-
cord-270892-ycc3csyh	688	31	.	.	.
cord-270892-ycc3csyh	689	1	They	-PRON-	PRP
cord-270892-ycc3csyh	689	2	showed	show	VBD
cord-270892-ycc3csyh	689	3	no	no	DT
cord-270892-ycc3csyh	689	4	significant	significant	JJ
cord-270892-ycc3csyh	689	5	cytotoxicity	cytotoxicity	NN
cord-270892-ycc3csyh	689	6	and	and	CC
cord-270892-ycc3csyh	689	7	were	be	VBD
cord-270892-ycc3csyh	689	8	highly	highly	RB
cord-270892-ycc3csyh	689	9	active	active	JJ
cord-270892-ycc3csyh	689	10	in	in	IN
cord-270892-ycc3csyh	689	11	tissue	tissue	NN
cord-270892-ycc3csyh	689	12	culture	culture	NN
cord-270892-ycc3csyh	689	13	against	against	IN
cord-270892-ycc3csyh	689	14	all	all	DT
cord-270892-ycc3csyh	689	15	human	human	JJ
cord-270892-ycc3csyh	689	16	picornaviruses	picornavirus	NNS
cord-270892-ycc3csyh	689	17	.	.	.
cord-270892-ycc3csyh	690	1	In	in	IN
cord-270892-ycc3csyh	690	2	tissue	tissue	NN
cord-270892-ycc3csyh	690	3	culture	culture	NN
cord-270892-ycc3csyh	690	4	,	,	,
cord-270892-ycc3csyh	690	5	cells	cell	NNS
cord-270892-ycc3csyh	690	6	infected	infect	VBN
cord-270892-ycc3csyh	690	7	with	with	IN
cord-270892-ycc3csyh	690	8	different	different	JJ
cord-270892-ycc3csyh	690	9	picornaviruses	picornavirus	NNS
cord-270892-ycc3csyh	690	10	(	(	-LRB-
cord-270892-ycc3csyh	690	11	among	among	IN
cord-270892-ycc3csyh	690	12	them	-PRON-	PRP
cord-270892-ycc3csyh	690	13	also	also	RB
cord-270892-ycc3csyh	690	14	HRV	HRV	NNP
cord-270892-ycc3csyh	690	15	)	)	-RRB-
cord-270892-ycc3csyh	691	1	no	no	DT
cord-270892-ycc3csyh	691	2	CPE	CPE	NNP
cord-270892-ycc3csyh	691	3	was	be	VBD
cord-270892-ycc3csyh	691	4	observed	observe	VBN
cord-270892-ycc3csyh	691	5	,	,	,
cord-270892-ycc3csyh	691	6	when	when	WRB
cord-270892-ycc3csyh	691	7	cells	cell	NNS
cord-270892-ycc3csyh	691	8	had	have	VBD
cord-270892-ycc3csyh	691	9	been	be	VBN
cord-270892-ycc3csyh	691	10	treated	treat	VBN
cord-270892-ycc3csyh	691	11	with	with	IN
cord-270892-ycc3csyh	691	12	2	2	CD
cord-270892-ycc3csyh	691	13	mg	mg	NNP
cord-270892-ycc3csyh	691	14	/	/	SYM
cord-270892-ycc3csyh	691	15	mL	ml	NN
cord-270892-ycc3csyh	691	16	of	of	IN
cord-270892-ycc3csyh	691	17	these	these	DT
cord-270892-ycc3csyh	691	18	3-methoxyflavones	3-methoxyflavones	CD
cord-270892-ycc3csyh	691	19	.	.	.
cord-270892-ycc3csyh	692	1	320	320	CD
cord-270892-ycc3csyh	693	1	The	the	DT
cord-270892-ycc3csyh	693	2	selection	selection	NN
cord-270892-ycc3csyh	693	3	of	of	IN
cord-270892-ycc3csyh	693	4	natural	natural	JJ
cord-270892-ycc3csyh	693	5	materials	material	NNS
cord-270892-ycc3csyh	693	6	based	base	VBN
cord-270892-ycc3csyh	693	7	on	on	IN
cord-270892-ycc3csyh	693	8	ethnopharmacology	ethnopharmacology	NNP
cord-270892-ycc3csyh	693	9	is	be	VBZ
cord-270892-ycc3csyh	693	10	a	a	DT
cord-270892-ycc3csyh	693	11	profound	profound	JJ
cord-270892-ycc3csyh	693	12	rationale	rationale	NN
cord-270892-ycc3csyh	693	13	for	for	IN
cord-270892-ycc3csyh	693	14	lead	lead	JJ
cord-270892-ycc3csyh	693	15	structure	structure	NN
cord-270892-ycc3csyh	693	16	discovery	discovery	NN
cord-270892-ycc3csyh	693	17	and	and	CC
cord-270892-ycc3csyh	693	18	highly	highly	RB
cord-270892-ycc3csyh	693	19	superior	superior	JJ
cord-270892-ycc3csyh	693	20	to	to	IN
cord-270892-ycc3csyh	693	21	random	random	JJ
cord-270892-ycc3csyh	693	22	selection	selection	NN
cord-270892-ycc3csyh	693	23	.	.	.
cord-270892-ycc3csyh	694	1	This	this	DT
cord-270892-ycc3csyh	694	2	however	however	RB
cord-270892-ycc3csyh	694	3	rarely	rarely	RB
cord-270892-ycc3csyh	694	4	applies	apply	VBZ
cord-270892-ycc3csyh	694	5	to	to	IN
cord-270892-ycc3csyh	694	6	marine	marine	JJ
cord-270892-ycc3csyh	694	7	organisms	organism	NNS
cord-270892-ycc3csyh	694	8	,	,	,
cord-270892-ycc3csyh	694	9	fungi	fungus	NNS
cord-270892-ycc3csyh	694	10	,	,	,
cord-270892-ycc3csyh	694	11	and	and	CC
cord-270892-ycc3csyh	694	12	microbes	microbe	NNS
cord-270892-ycc3csyh	694	13	.	.	.
cord-270892-ycc3csyh	695	1	Although	although	IN
cord-270892-ycc3csyh	695	2	these	these	DT
cord-270892-ycc3csyh	695	3	organisms	organism	NNS
cord-270892-ycc3csyh	695	4	are	be	VBP
cord-270892-ycc3csyh	695	5	esteemed	esteem	VBN
cord-270892-ycc3csyh	695	6	as	as	IN
cord-270892-ycc3csyh	695	7	highly	highly	RB
cord-270892-ycc3csyh	695	8	valuable	valuable	JJ
cord-270892-ycc3csyh	695	9	source	source	NN
cord-270892-ycc3csyh	695	10	for	for	IN
cord-270892-ycc3csyh	695	11	bioactive	bioactive	JJ
cord-270892-ycc3csyh	695	12	metabolites	metabolite	NNS
cord-270892-ycc3csyh	695	13	,	,	,
cord-270892-ycc3csyh	695	14	322	322	CD
cord-270892-ycc3csyh	695	15	hardly	hardly	RB
cord-270892-ycc3csyh	695	16	any	any	DT
cord-270892-ycc3csyh	695	17	records	record	NNS
cord-270892-ycc3csyh	695	18	from	from	IN
cord-270892-ycc3csyh	695	19	folk	folk	NN
cord-270892-ycc3csyh	695	20	medicine	medicine	NN
cord-270892-ycc3csyh	695	21	are	be	VBP
cord-270892-ycc3csyh	695	22	given	give	VBN
cord-270892-ycc3csyh	695	23	for	for	IN
cord-270892-ycc3csyh	695	24	them	-PRON-	PRP
cord-270892-ycc3csyh	695	25	.	.	.
cord-270892-ycc3csyh	696	1	A	a	DT
cord-270892-ycc3csyh	696	2	medium	medium	JJ
cord-270892-ycc3csyh	696	3	-	-	HYPH
cord-270892-ycc3csyh	696	4	sized	sized	JJ
cord-270892-ycc3csyh	696	5	activity	activity	NN
cord-270892-ycc3csyh	696	6	screening	screening	NN
cord-270892-ycc3csyh	696	7	using	use	VBG
cord-270892-ycc3csyh	696	8	a	a	DT
cord-270892-ycc3csyh	696	9	robust	robust	JJ
cord-270892-ycc3csyh	696	10	cell	cell	NN
cord-270892-ycc3csyh	696	11	-	-	HYPH
cord-270892-ycc3csyh	696	12	based	base	VBN
cord-270892-ycc3csyh	696	13	or	or	CC
cord-270892-ycc3csyh	696	14	in	in	IN
cord-270892-ycc3csyh	696	15	vitro	vitro	NN
cord-270892-ycc3csyh	696	16	-	-	HYPH
cord-270892-ycc3csyh	696	17	assay	assay	NN
cord-270892-ycc3csyh	696	18	with	with	IN
cord-270892-ycc3csyh	696	19	reasonable	reasonable	JJ
cord-270892-ycc3csyh	696	20	effort	effort	NN
cord-270892-ycc3csyh	696	21	as	as	IN
cord-270892-ycc3csyh	696	22	to	to	IN
cord-270892-ycc3csyh	696	23	time	time	NN
cord-270892-ycc3csyh	696	24	and	and	CC
cord-270892-ycc3csyh	696	25	costs	cost	NNS
cord-270892-ycc3csyh	696	26	is	be	VBZ
cord-270892-ycc3csyh	696	27	a	a	DT
cord-270892-ycc3csyh	696	28	strategy	strategy	NN
cord-270892-ycc3csyh	696	29	to	to	TO
cord-270892-ycc3csyh	696	30	get	get	VB
cord-270892-ycc3csyh	696	31	a	a	DT
cord-270892-ycc3csyh	696	32	first	first	JJ
cord-270892-ycc3csyh	696	33	insight	insight	NN
cord-270892-ycc3csyh	696	34	into	into	IN
cord-270892-ycc3csyh	696	35	the	the	DT
cord-270892-ycc3csyh	696	36	antiviral	antiviral	JJ
cord-270892-ycc3csyh	696	37	activities	activity	NNS
cord-270892-ycc3csyh	696	38	of	of	IN
cord-270892-ycc3csyh	696	39	extracts	extract	NNS
cord-270892-ycc3csyh	696	40	,	,	,
cord-270892-ycc3csyh	696	41	fractions	fraction	NNS
cord-270892-ycc3csyh	696	42	,	,	,
cord-270892-ycc3csyh	696	43	and	and	CC
cord-270892-ycc3csyh	696	44	compounds	compound	NNS
cord-270892-ycc3csyh	696	45	from	from	IN
cord-270892-ycc3csyh	696	46	synthesis	synthesis	NN
cord-270892-ycc3csyh	696	47	or	or	CC
cord-270892-ycc3csyh	696	48	nature	nature	NN
cord-270892-ycc3csyh	696	49	.	.	.
cord-270892-ycc3csyh	697	1	For	for	IN
cord-270892-ycc3csyh	697	2	the	the	DT
cord-270892-ycc3csyh	697	3	discovery	discovery	NN
cord-270892-ycc3csyh	697	4	of	of	IN
cord-270892-ycc3csyh	697	5	novel	novel	NN
cord-270892-ycc3csyh	697	6	naturally	naturally	RB
cord-270892-ycc3csyh	697	7	based	base	VBN
cord-270892-ycc3csyh	697	8	HRV	HRV	NNP
cord-270892-ycc3csyh	697	9	3C	3c	NN
cord-270892-ycc3csyh	697	10	-	-	HYPH
cord-270892-ycc3csyh	697	11	protease	protease	NN
cord-270892-ycc3csyh	697	12	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	697	13	,	,	,
cord-270892-ycc3csyh	697	14	Singh	Singh	NNP
cord-270892-ycc3csyh	697	15	et	et	NNP
cord-270892-ycc3csyh	697	16	al	al	NNP
cord-270892-ycc3csyh	697	17	.	.	NNP
cord-270892-ycc3csyh	697	18	used	use	VBD
cord-270892-ycc3csyh	697	19	a	a	DT
cord-270892-ycc3csyh	697	20	small	small	JJ
cord-270892-ycc3csyh	697	21	peptide	peptide	NN
cord-270892-ycc3csyh	697	22	containing	contain	VBG
cord-270892-ycc3csyh	697	23	Q	Q	NNP
cord-270892-ycc3csyh	697	24	-	-	HYPH
cord-270892-ycc3csyh	697	25	G	g	NN
cord-270892-ycc3csyh	697	26	scissile	scissile	NN
cord-270892-ycc3csyh	697	27	bond	bond	NN
cord-270892-ycc3csyh	697	28	as	as	IN
cord-270892-ycc3csyh	697	29	substrate	substrate	NN
cord-270892-ycc3csyh	697	30	for	for	IN
cord-270892-ycc3csyh	697	31	the	the	DT
cord-270892-ycc3csyh	697	32	in	in	FW
cord-270892-ycc3csyh	697	33	vitro	vitro	FW
cord-270892-ycc3csyh	697	34	screening	screening	NN
cord-270892-ycc3csyh	697	35	of	of	IN
cord-270892-ycc3csyh	697	36	extracts	extract	NNS
cord-270892-ycc3csyh	697	37	.	.	.
cord-270892-ycc3csyh	698	1	The	the	DT
cord-270892-ycc3csyh	698	2	authors	author	NNS
cord-270892-ycc3csyh	698	3	isolated	isolate	VBD
cord-270892-ycc3csyh	698	4	the	the	DT
cord-270892-ycc3csyh	698	5	novel	novel	JJ
cord-270892-ycc3csyh	698	6	benzoisochromanquinone	benzoisochromanquinone	NN
cord-270892-ycc3csyh	698	7	(	(	-LRB-
cord-270892-ycc3csyh	698	8	1)-thysanone	1)-thysanone	CD
cord-270892-ycc3csyh	698	9	(	(	-LRB-
cord-270892-ycc3csyh	698	10	Fig	Fig	NNP
cord-270892-ycc3csyh	698	11	.	.	NNP
cord-270892-ycc3csyh	698	12	5	5	CD
cord-270892-ycc3csyh	698	13	;	;	:
cord-270892-ycc3csyh	698	14	Table	Table	NNP
cord-270892-ycc3csyh	698	15	III	iii	CD
cord-270892-ycc3csyh	698	16	)	)	-RRB-
cord-270892-ycc3csyh	698	17	from	from	IN
cord-270892-ycc3csyh	698	18	an	an	DT
cord-270892-ycc3csyh	698	19	extract	extract	NN
cord-270892-ycc3csyh	698	20	of	of	IN
cord-270892-ycc3csyh	698	21	the	the	DT
cord-270892-ycc3csyh	698	22	fungus	fungus	NN
cord-270892-ycc3csyh	698	23	Thysanophora	Thysanophora	NNP
cord-270892-ycc3csyh	698	24	penicilloides	penicilloide	VBZ
cord-270892-ycc3csyh	698	25	with	with	IN
cord-270892-ycc3csyh	698	26	potent	potent	JJ
cord-270892-ycc3csyh	698	27	HRV	HRV	NNP
cord-270892-ycc3csyh	698	28	3C	3c	NN
cord-270892-ycc3csyh	698	29	-	-	HYPH
cord-270892-ycc3csyh	698	30	protease	protease	NN
cord-270892-ycc3csyh	698	31	inhibitory	inhibitory	JJ
cord-270892-ycc3csyh	698	32	activity	activity	NN
cord-270892-ycc3csyh	698	33	.	.	.
cord-270892-ycc3csyh	699	1	323	323	CD
cord-270892-ycc3csyh	699	2	A	a	DT
cord-270892-ycc3csyh	699	3	continued	continue	VBN
cord-270892-ycc3csyh	699	4	screening	screening	NN
cord-270892-ycc3csyh	699	5	revealed	reveal	VBD
cord-270892-ycc3csyh	699	6	a	a	DT
cord-270892-ycc3csyh	699	7	pronounced	pronounce	VBN
cord-270892-ycc3csyh	699	8	HRV	HRV	NNP
cord-270892-ycc3csyh	699	9	3C	3c	NN
cord-270892-ycc3csyh	699	10	-	-	HYPH
cord-270892-ycc3csyh	699	11	protease	protease	NN
cord-270892-ycc3csyh	699	12	inhibitory	inhibitory	JJ
cord-270892-ycc3csyh	699	13	activity	activity	NN
cord-270892-ycc3csyh	699	14	for	for	IN
cord-270892-ycc3csyh	699	15	the	the	DT
cord-270892-ycc3csyh	699	16	extract	extract	NN
cord-270892-ycc3csyh	699	17	of	of	IN
cord-270892-ycc3csyh	699	18	the	the	DT
cord-270892-ycc3csyh	699	19	Chinese	chinese	JJ
cord-270892-ycc3csyh	699	20	herb	herb	NN
cord-270892-ycc3csyh	699	21	Polygonum	polygonum	NN
cord-270892-ycc3csyh	699	22	cuspidatum	cuspidatum	NN
cord-270892-ycc3csyh	699	23	.	.	.
cord-270892-ycc3csyh	700	1	By	by	IN
cord-270892-ycc3csyh	700	2	bioassay	bioassay	NN
cord-270892-ycc3csyh	700	3	-	-	HYPH
cord-270892-ycc3csyh	700	4	guided	guide	VBN
cord-270892-ycc3csyh	700	5	fractionation	fractionation	NN
cord-270892-ycc3csyh	700	6	2-methoxystypandrone	2-methoxystypandrone	CD
cord-270892-ycc3csyh	700	7	(	(	-LRB-
cord-270892-ycc3csyh	700	8	Fig	Fig	NNP
cord-270892-ycc3csyh	700	9	.	.	NNP
cord-270892-ycc3csyh	700	10	5	5	CD
cord-270892-ycc3csyh	700	11	;	;	:
cord-270892-ycc3csyh	700	12	Table	Table	NNP
cord-270892-ycc3csyh	700	13	III	III	NNP
cord-270892-ycc3csyh	700	14	)	)	-RRB-
cord-270892-ycc3csyh	700	15	,	,	,
cord-270892-ycc3csyh	700	16	a	a	DT
cord-270892-ycc3csyh	700	17	naphthoquinone	naphthoquinone	NN
cord-270892-ycc3csyh	700	18	,	,	,
cord-270892-ycc3csyh	700	19	with	with	IN
cord-270892-ycc3csyh	700	20	an	an	DT
cord-270892-ycc3csyh	700	21	IC	IC	NNP
cord-270892-ycc3csyh	700	22	50	50	CD
cord-270892-ycc3csyh	700	23	value	value	NN
cord-270892-ycc3csyh	700	24	of	of	IN
cord-270892-ycc3csyh	700	25	4.6	4.6	CD
cord-270892-ycc3csyh	700	26	mM	mm	CD
cord-270892-ycc3csyh	700	27	,	,	,
cord-270892-ycc3csyh	700	28	was	be	VBD
cord-270892-ycc3csyh	700	29	isolated	isolate	VBN
cord-270892-ycc3csyh	700	30	from	from	IN
cord-270892-ycc3csyh	700	31	the	the	DT
cord-270892-ycc3csyh	700	32	plant	plant	NN
cord-270892-ycc3csyh	700	33	material	material	NN
cord-270892-ycc3csyh	700	34	.	.	.
cord-270892-ycc3csyh	701	1	The	the	DT
cord-270892-ycc3csyh	701	2	total	total	JJ
cord-270892-ycc3csyh	701	3	syntheses	synthesis	NNS
cord-270892-ycc3csyh	701	4	of	of	IN
cord-270892-ycc3csyh	701	5	this	this	DT
cord-270892-ycc3csyh	701	6	natural	natural	JJ
cord-270892-ycc3csyh	701	7	compound	compound	NN
cord-270892-ycc3csyh	701	8	and	and	CC
cord-270892-ycc3csyh	701	9	further	further	JJ
cord-270892-ycc3csyh	701	10	analogues	analogue	NNS
cord-270892-ycc3csyh	701	11	allowed	allow	VBN
cord-270892-ycc3csyh	701	12	for	for	IN
cord-270892-ycc3csyh	701	13	a	a	DT
cord-270892-ycc3csyh	701	14	structure	structure	NN
cord-270892-ycc3csyh	701	15	-	-	HYPH
cord-270892-ycc3csyh	701	16	activity	activity	NN
cord-270892-ycc3csyh	701	17	relationship	relationship	NN
cord-270892-ycc3csyh	701	18	,	,	,
cord-270892-ycc3csyh	701	19	and	and	CC
cord-270892-ycc3csyh	701	20	particularly	particularly	RB
cord-270892-ycc3csyh	701	21	the	the	DT
cord-270892-ycc3csyh	701	22	comparison	comparison	NN
cord-270892-ycc3csyh	701	23	between	between	IN
cord-270892-ycc3csyh	701	24	activities	activity	NNS
cord-270892-ycc3csyh	701	25	of	of	IN
cord-270892-ycc3csyh	701	26	ortho	ortho	NNP
cord-270892-ycc3csyh	701	27	-	-	HYPH
cord-270892-ycc3csyh	701	28	vs	vs	NNP
cord-270892-ycc3csyh	701	29	.	.	.
cord-270892-ycc3csyh	701	30	para	para	NNP
cord-270892-ycc3csyh	701	31	-	-	HYPH
cord-270892-ycc3csyh	701	32	quinones	quinones	NNP
cord-270892-ycc3csyh	701	33	.	.	.
cord-270892-ycc3csyh	702	1	To	to	TO
cord-270892-ycc3csyh	702	2	measure	measure	VB
cord-270892-ycc3csyh	702	3	the	the	DT
cord-270892-ycc3csyh	702	4	selectivity	selectivity	NN
cord-270892-ycc3csyh	702	5	of	of	IN
cord-270892-ycc3csyh	702	6	the	the	DT
cord-270892-ycc3csyh	702	7	compound	compound	NN
cord-270892-ycc3csyh	702	8	series	series	NN
cord-270892-ycc3csyh	702	9	against	against	IN
cord-270892-ycc3csyh	702	10	cystein	cystein	NNP
cord-270892-ycc3csyh	702	11	proteases	protease	NNS
cord-270892-ycc3csyh	702	12	other	other	JJ
cord-270892-ycc3csyh	702	13	than	than	IN
cord-270892-ycc3csyh	702	14	HRV	HRV	NNP
cord-270892-ycc3csyh	702	15	3C	3c	NN
cord-270892-ycc3csyh	702	16	-	-	HYPH
cord-270892-ycc3csyh	702	17	protease	protease	NN
cord-270892-ycc3csyh	702	18	,	,	,
cord-270892-ycc3csyh	702	19	the	the	DT
cord-270892-ycc3csyh	702	20	compounds	compound	NNS
cord-270892-ycc3csyh	702	21	were	be	VBD
cord-270892-ycc3csyh	702	22	evaluated	evaluate	VBN
cord-270892-ycc3csyh	702	23	against	against	IN
cord-270892-ycc3csyh	702	24	papain	papain	NN
cord-270892-ycc3csyh	702	25	.	.	.
cord-270892-ycc3csyh	703	1	The	the	DT
cord-270892-ycc3csyh	703	2	simple	simple	JJ
cord-270892-ycc3csyh	703	3	9,10-phenanthraquinone	9,10-phenanthraquinone	CD
cord-270892-ycc3csyh	703	4	(	(	-LRB-
cord-270892-ycc3csyh	703	5	Fig	fig	NN
cord-270892-ycc3csyh	703	6	.	.	NNP
cord-270892-ycc3csyh	703	7	5	5	CD
cord-270892-ycc3csyh	703	8	;	;	:
cord-270892-ycc3csyh	703	9	Table	Table	NNP
cord-270892-ycc3csyh	703	10	III	III	NNP
cord-270892-ycc3csyh	703	11	)	)	-RRB-
cord-270892-ycc3csyh	703	12	was	be	VBD
cord-270892-ycc3csyh	703	13	the	the	DT
cord-270892-ycc3csyh	703	14	most	most	RBS
cord-270892-ycc3csyh	703	15	active	active	JJ
cord-270892-ycc3csyh	703	16	compound	compound	NN
cord-270892-ycc3csyh	703	17	of	of	IN
cord-270892-ycc3csyh	703	18	the	the	DT
cord-270892-ycc3csyh	703	19	series	series	NN
cord-270892-ycc3csyh	703	20	and	and	CC
cord-270892-ycc3csyh	703	21	showed	show	VBD
cord-270892-ycc3csyh	703	22	an	an	DT
cord-270892-ycc3csyh	703	23	IC	IC	NNP
cord-270892-ycc3csyh	703	24	50	50	CD
cord-270892-ycc3csyh	703	25	value	value	NN
cord-270892-ycc3csyh	703	26	of	of	IN
cord-270892-ycc3csyh	703	27	1.4	1.4	CD
cord-270892-ycc3csyh	703	28	mM	mm	CD
cord-270892-ycc3csyh	703	29	with	with	IN
cord-270892-ycc3csyh	703	30	a	a	DT
cord-270892-ycc3csyh	703	31	distinctly	distinctly	RB
cord-270892-ycc3csyh	703	32	higher	high	JJR
cord-270892-ycc3csyh	703	33	degree	degree	NN
cord-270892-ycc3csyh	703	34	of	of	IN
cord-270892-ycc3csyh	703	35	selectivity	selectivity	NN
cord-270892-ycc3csyh	703	36	than	than	IN
cord-270892-ycc3csyh	703	37	2-methoxystypandrone	2-methoxystypandrone	CD
cord-270892-ycc3csyh	703	38	.	.	.
cord-270892-ycc3csyh	704	1	324	324	CD
cord-270892-ycc3csyh	705	1	A	a	DT
cord-270892-ycc3csyh	705	2	CPE	CPE	NNP
cord-270892-ycc3csyh	705	3	reduction	reduction	NN
cord-270892-ycc3csyh	705	4	assay	assay	NN
cord-270892-ycc3csyh	705	5	was	be	VBD
cord-270892-ycc3csyh	705	6	applied	apply	VBN
cord-270892-ycc3csyh	705	7	for	for	IN
cord-270892-ycc3csyh	705	8	the	the	DT
cord-270892-ycc3csyh	705	9	identification	identification	NN
cord-270892-ycc3csyh	705	10	of	of	IN
cord-270892-ycc3csyh	705	11	raoulic	raoulic	JJ
cord-270892-ycc3csyh	705	12	acid	acid	NN
cord-270892-ycc3csyh	705	13	,	,	,
cord-270892-ycc3csyh	705	14	a	a	DT
cord-270892-ycc3csyh	705	15	bicyclic	bicyclic	JJ
cord-270892-ycc3csyh	705	16	C25	c25	NN
cord-270892-ycc3csyh	705	17	terpene	terpene	NN
cord-270892-ycc3csyh	705	18	acid	acid	NN
cord-270892-ycc3csyh	705	19	(	(	-LRB-
cord-270892-ycc3csyh	705	20	Fig	Fig	NNP
cord-270892-ycc3csyh	705	21	.	.	NNP
cord-270892-ycc3csyh	705	22	5	5	CD
cord-270892-ycc3csyh	705	23	;	;	:
cord-270892-ycc3csyh	705	24	Table	Table	NNP
cord-270892-ycc3csyh	705	25	III	iii	CD
cord-270892-ycc3csyh	705	26	)	)	-RRB-
cord-270892-ycc3csyh	705	27	isolated	isolate	VBN
cord-270892-ycc3csyh	705	28	from	from	IN
cord-270892-ycc3csyh	705	29	Raoulia	Raoulia	NNP
cord-270892-ycc3csyh	705	30	australis	australis	NN
cord-270892-ycc3csyh	705	31	(	(	-LRB-
cord-270892-ycc3csyh	705	32	Asteraceae	Asteraceae	NNP
cord-270892-ycc3csyh	705	33	)	)	-RRB-
cord-270892-ycc3csyh	705	34	.	.	.
cord-270892-ycc3csyh	706	1	Raoulic	Raoulic	NNP
cord-270892-ycc3csyh	706	2	acid	acid	NN
cord-270892-ycc3csyh	706	3	exerted	exert	VBD
cord-270892-ycc3csyh	706	4	an	an	DT
cord-270892-ycc3csyh	706	5	antiviral	antiviral	JJ
cord-270892-ycc3csyh	706	6	activity	activity	NN
cord-270892-ycc3csyh	706	7	against	against	IN
cord-270892-ycc3csyh	706	8	coxsackie	coxsackie	NNP
cord-270892-ycc3csyh	706	9	virus	virus	NN
cord-270892-ycc3csyh	706	10	B3	B3	NNP
cord-270892-ycc3csyh	706	11	,	,	,
cord-270892-ycc3csyh	706	12	B4	B4	NNP
cord-270892-ycc3csyh	706	13	,	,	,
cord-270892-ycc3csyh	706	14	enterovirus	enterovirus	NN
cord-270892-ycc3csyh	706	15	71	71	CD
cord-270892-ycc3csyh	706	16	,	,	,
cord-270892-ycc3csyh	706	17	and	and	CC
cord-270892-ycc3csyh	706	18	HRV-2	HRV-2	NNP
cord-270892-ycc3csyh	707	1	and	and	CC
cord-270892-ycc3csyh	707	2	-3	-3	NNP
cord-270892-ycc3csyh	707	3	with	with	IN
cord-270892-ycc3csyh	707	4	IC	IC	NNP
cord-270892-ycc3csyh	707	5	50	50	CD
cord-270892-ycc3csyh	707	6	values	value	NNS
cord-270892-ycc3csyh	707	7	in	in	IN
cord-270892-ycc3csyh	707	8	the	the	DT
cord-270892-ycc3csyh	707	9	submicromolar	submicromolar	NNP
cord-270892-ycc3csyh	707	10	range	range	NN
cord-270892-ycc3csyh	707	11	.	.	.
cord-270892-ycc3csyh	708	1	No	no	DT
cord-270892-ycc3csyh	708	2	activity	activity	NN
cord-270892-ycc3csyh	708	3	was	be	VBD
cord-270892-ycc3csyh	708	4	recorded	record	VBN
cord-270892-ycc3csyh	708	5	against	against	IN
cord-270892-ycc3csyh	708	6	influenza	influenza	NN
cord-270892-ycc3csyh	708	7	A	a	NN
cord-270892-ycc3csyh	708	8	and	and	CC
cord-270892-ycc3csyh	708	9	B	b	NN
cord-270892-ycc3csyh	708	10	viruses	virus	NNS
cord-270892-ycc3csyh	708	11	.	.	.
cord-270892-ycc3csyh	709	1	325	325	CD
cord-270892-ycc3csyh	710	1	In	in	IN
cord-270892-ycc3csyh	710	2	the	the	DT
cord-270892-ycc3csyh	710	3	course	course	NN
cord-270892-ycc3csyh	710	4	of	of	IN
cord-270892-ycc3csyh	710	5	the	the	DT
cord-270892-ycc3csyh	710	6	systematic	systematic	JJ
cord-270892-ycc3csyh	710	7	screening	screening	NN
cord-270892-ycc3csyh	710	8	of	of	IN
cord-270892-ycc3csyh	710	9	microbial	microbial	JJ
cord-270892-ycc3csyh	710	10	and	and	CC
cord-270892-ycc3csyh	710	11	natural	natural	JJ
cord-270892-ycc3csyh	710	12	products	product	NNS
cord-270892-ycc3csyh	710	13	for	for	IN
cord-270892-ycc3csyh	710	14	anti	anti	JJ
cord-270892-ycc3csyh	710	15	-	-	JJ
cord-270892-ycc3csyh	710	16	HRV	HRV	NNP
cord-270892-ycc3csyh	710	17	activity	activity	NN
cord-270892-ycc3csyh	710	18	,	,	,
cord-270892-ycc3csyh	710	19	Ishitsuka	Ishitsuka	NNP
cord-270892-ycc3csyh	710	20	et	et	NNP
cord-270892-ycc3csyh	710	21	al	al	NNP
cord-270892-ycc3csyh	710	22	.	.	NNP
cord-270892-ycc3csyh	710	23	identified	identify	VBD
cord-270892-ycc3csyh	710	24	4	4	CD
cord-270892-ycc3csyh	710	25	0	0	CD
cord-270892-ycc3csyh	710	26	,	,	,
cord-270892-ycc3csyh	710	27	5-dihydroxy-3,3	5-dihydroxy-3,3	CD
cord-270892-ycc3csyh	710	28	0	0	CD
cord-270892-ycc3csyh	710	29	,	,	,
cord-270892-ycc3csyh	711	1	7-trimethoxyflavone	7-trimethoxyflavone	CD
cord-270892-ycc3csyh	711	2	(	(	-LRB-
cord-270892-ycc3csyh	711	3	Fig	Fig	NNP
cord-270892-ycc3csyh	711	4	.	.	NNP
cord-270892-ycc3csyh	711	5	5	5	CD
cord-270892-ycc3csyh	711	6	;	;	:
cord-270892-ycc3csyh	711	7	Table	Table	NNP
cord-270892-ycc3csyh	711	8	III	iii	CD
cord-270892-ycc3csyh	711	9	)	)	-RRB-
cord-270892-ycc3csyh	711	10	from	from	IN
cord-270892-ycc3csyh	711	11	the	the	DT
cord-270892-ycc3csyh	711	12	leaves	leave	NNS
cord-270892-ycc3csyh	711	13	of	of	IN
cord-270892-ycc3csyh	711	14	the	the	DT
cord-270892-ycc3csyh	711	15	Chinese	chinese	JJ
cord-270892-ycc3csyh	711	16	medicinal	medicinal	JJ
cord-270892-ycc3csyh	711	17	plant	plant	NN
cord-270892-ycc3csyh	711	18	Agastache	Agastache	NNP
cord-270892-ycc3csyh	711	19	rugosa	rugosa	NNP
cord-270892-ycc3csyh	711	20	(	(	-LRB-
cord-270892-ycc3csyh	711	21	Lamiaceae	Lamiaceae	NNP
cord-270892-ycc3csyh	711	22	)	)	-RRB-
cord-270892-ycc3csyh	711	23	as	as	IN
cord-270892-ycc3csyh	711	24	natural	natural	JJ
cord-270892-ycc3csyh	711	25	compound	compound	NN
cord-270892-ycc3csyh	711	26	with	with	IN
cord-270892-ycc3csyh	711	27	high	high	JJ
cord-270892-ycc3csyh	711	28	activity	activity	NN
cord-270892-ycc3csyh	711	29	against	against	IN
cord-270892-ycc3csyh	711	30	all	all	DT
cord-270892-ycc3csyh	711	31	picornaviruses	picornavirus	NNS
cord-270892-ycc3csyh	711	32	except	except	IN
cord-270892-ycc3csyh	711	33	mengovirus	mengovirus	NNP
cord-270892-ycc3csyh	711	34	.	.	.
cord-270892-ycc3csyh	712	1	The	the	DT
cord-270892-ycc3csyh	712	2	authors	author	NNS
cord-270892-ycc3csyh	712	3	synthesized	synthesize	VBD
cord-270892-ycc3csyh	712	4	the	the	DT
cord-270892-ycc3csyh	712	5	orally	orally	RB
cord-270892-ycc3csyh	712	6	active	active	JJ
cord-270892-ycc3csyh	712	7	4	4	CD
cord-270892-ycc3csyh	712	8	0	0	CD
cord-270892-ycc3csyh	712	9	,	,	,
cord-270892-ycc3csyh	712	10	5-diacetyloxy-3,3	5-diacetyloxy-3,3	CD
cord-270892-ycc3csyh	712	11	0	0	CD
cord-270892-ycc3csyh	712	12	,	,	,
cord-270892-ycc3csyh	712	13	7-trimethoxyflavone	7-trimethoxyflavone	CD
cord-270892-ycc3csyh	712	14	and	and	CC
cord-270892-ycc3csyh	712	15	performed	perform	VBN
cord-270892-ycc3csyh	712	16	investigations	investigation	NNS
cord-270892-ycc3csyh	712	17	in	in	IN
cord-270892-ycc3csyh	712	18	tissue	tissue	NN
cord-270892-ycc3csyh	712	19	cultures	culture	NNS
cord-270892-ycc3csyh	712	20	and	and	CC
cord-270892-ycc3csyh	712	21	in	in	IN
cord-270892-ycc3csyh	712	22	mice	mouse	NNS
cord-270892-ycc3csyh	712	23	to	to	TO
cord-270892-ycc3csyh	712	24	determine	determine	VB
cord-270892-ycc3csyh	712	25	the	the	DT
cord-270892-ycc3csyh	712	26	compound	compound	NN
cord-270892-ycc3csyh	712	27	's	's	POS
cord-270892-ycc3csyh	712	28	mode	mode	NN
cord-270892-ycc3csyh	712	29	of	of	IN
cord-270892-ycc3csyh	712	30	action	action	NN
cord-270892-ycc3csyh	712	31	.	.	.
cord-270892-ycc3csyh	713	1	This	this	DT
cord-270892-ycc3csyh	713	2	was	be	VBD
cord-270892-ycc3csyh	713	3	assumed	assume	VBN
cord-270892-ycc3csyh	713	4	to	to	TO
cord-270892-ycc3csyh	713	5	be	be	VB
cord-270892-ycc3csyh	713	6	the	the	DT
cord-270892-ycc3csyh	713	7	process	process	NN
cord-270892-ycc3csyh	713	8	of	of	IN
cord-270892-ycc3csyh	713	9	viral	viral	JJ
cord-270892-ycc3csyh	713	10	replication	replication	NN
cord-270892-ycc3csyh	713	11	,	,	,
cord-270892-ycc3csyh	713	12	thus	thus	RB
cord-270892-ycc3csyh	713	13	located	locate	VBN
cord-270892-ycc3csyh	713	14	between	between	IN
cord-270892-ycc3csyh	713	15	viral	viral	JJ
cord-270892-ycc3csyh	713	16	uncoating	uncoating	NN
cord-270892-ycc3csyh	713	17	and	and	CC
cord-270892-ycc3csyh	713	18	initiation	initiation	NN
cord-270892-ycc3csyh	713	19	of	of	IN
cord-270892-ycc3csyh	713	20	viral	viral	JJ
cord-270892-ycc3csyh	713	21	RNA	RNA	NNP
cord-270892-ycc3csyh	713	22	synthesis	synthesis	NN
cord-270892-ycc3csyh	713	23	.	.	.
cord-270892-ycc3csyh	714	1	326	326	CD
cord-270892-ycc3csyh	715	1	The	the	DT
cord-270892-ycc3csyh	715	2	activity	activity	NN
cord-270892-ycc3csyh	715	3	of	of	IN
cord-270892-ycc3csyh	715	4	flavan	flavan	NNP
cord-270892-ycc3csyh	715	5	(	(	-LRB-
cord-270892-ycc3csyh	715	6	Fig	Fig	NNP
cord-270892-ycc3csyh	715	7	.	.	NNP
cord-270892-ycc3csyh	715	8	5	5	CD
cord-270892-ycc3csyh	715	9	;	;	:
cord-270892-ycc3csyh	715	10	Table	Table	NNP
cord-270892-ycc3csyh	715	11	III	III	NNP
cord-270892-ycc3csyh	715	12	)	)	-RRB-
cord-270892-ycc3csyh	715	13	was	be	VBD
cord-270892-ycc3csyh	715	14	discovered	discover	VBN
cord-270892-ycc3csyh	715	15	serendipitously	serendipitously	RB
cord-270892-ycc3csyh	715	16	during	during	IN
cord-270892-ycc3csyh	715	17	a	a	DT
cord-270892-ycc3csyh	715	18	screening	screening	NN
cord-270892-ycc3csyh	715	19	program	program	NN
cord-270892-ycc3csyh	715	20	by	by	IN
cord-270892-ycc3csyh	715	21	using	use	VBG
cord-270892-ycc3csyh	715	22	a	a	DT
cord-270892-ycc3csyh	715	23	plaque	plaque	NN
cord-270892-ycc3csyh	715	24	inhibition	inhibition	NN
cord-270892-ycc3csyh	715	25	assay	assay	NN
cord-270892-ycc3csyh	715	26	.	.	.
cord-270892-ycc3csyh	716	1	194	194	CD
cord-270892-ycc3csyh	717	1	Based	base	VBN
cord-270892-ycc3csyh	717	2	on	on	IN
cord-270892-ycc3csyh	717	3	these	these	DT
cord-270892-ycc3csyh	717	4	results	result	NNS
cord-270892-ycc3csyh	717	5	,	,	,
cord-270892-ycc3csyh	717	6	Bauer	Bauer	NNP
cord-270892-ycc3csyh	717	7	et	et	NNP
cord-270892-ycc3csyh	717	8	al	al	NNP
cord-270892-ycc3csyh	717	9	.	.	.
cord-270892-ycc3csyh	717	10	synthesized	synthesize	VBN
cord-270892-ycc3csyh	717	11	4	4	CD
cord-270892-ycc3csyh	717	12	0	0	CD
cord-270892-ycc3csyh	718	1	,	,	,
cord-270892-ycc3csyh	718	2	6-dichloroflavan	6-dichloroflavan	CD
cord-270892-ycc3csyh	718	3	(	(	-LRB-
cord-270892-ycc3csyh	718	4	BW863C	BW863C	NNP
cord-270892-ycc3csyh	718	5	,	,	,
cord-270892-ycc3csyh	718	6	Fig	Fig	NNP
cord-270892-ycc3csyh	718	7	.	.	NNP
cord-270892-ycc3csyh	718	8	2	2	CD
cord-270892-ycc3csyh	718	9	;	;	:
cord-270892-ycc3csyh	718	10	Table	Table	NNP
cord-270892-ycc3csyh	718	11	II	II	NNP
cord-270892-ycc3csyh	718	12	)	)	-RRB-
cord-270892-ycc3csyh	718	13	,	,	,
cord-270892-ycc3csyh	718	14	which	which	WDT
cord-270892-ycc3csyh	718	15	revealed	reveal	VBD
cord-270892-ycc3csyh	718	16	an	an	DT
cord-270892-ycc3csyh	718	17	activity	activity	NN
cord-270892-ycc3csyh	718	18	against	against	IN
cord-270892-ycc3csyh	718	19	a	a	DT
cord-270892-ycc3csyh	718	20	number	number	NN
cord-270892-ycc3csyh	718	21	of	of	IN
cord-270892-ycc3csyh	718	22	HRV	HRV	NNP
cord-270892-ycc3csyh	718	23	serotypes	serotype	NNS
cord-270892-ycc3csyh	718	24	in	in	IN
cord-270892-ycc3csyh	718	25	the	the	DT
cord-270892-ycc3csyh	718	26	range	range	NN
cord-270892-ycc3csyh	718	27	between	between	IN
cord-270892-ycc3csyh	718	28	0.007	0.007	CD
cord-270892-ycc3csyh	718	29	and	and	CC
cord-270892-ycc3csyh	718	30	10	10	CD
cord-270892-ycc3csyh	718	31	mM.	mm.	NN
cord-270892-ycc3csyh	719	1	As	as	RB
cord-270892-ycc3csyh	719	2	soon	soon	RB
cord-270892-ycc3csyh	719	3	as	as	IN
cord-270892-ycc3csyh	719	4	an	an	DT
cord-270892-ycc3csyh	719	5	active	active	JJ
cord-270892-ycc3csyh	719	6	lead	lead	NN
cord-270892-ycc3csyh	719	7	compound	compound	NN
cord-270892-ycc3csyh	719	8	is	be	VBZ
cord-270892-ycc3csyh	719	9	identified	identify	VBN
cord-270892-ycc3csyh	719	10	it	-PRON-	PRP
cord-270892-ycc3csyh	719	11	is	be	VBZ
cord-270892-ycc3csyh	719	12	of	of	IN
cord-270892-ycc3csyh	719	13	utmost	utmost	JJ
cord-270892-ycc3csyh	719	14	importance	importance	NN
cord-270892-ycc3csyh	719	15	to	to	TO
cord-270892-ycc3csyh	719	16	scrutinize	scrutinize	VB
cord-270892-ycc3csyh	719	17	the	the	DT
cord-270892-ycc3csyh	719	18	derivatives	derivative	NNS
cord-270892-ycc3csyh	719	19	'	'	POS
cord-270892-ycc3csyh	719	20	activity	activity	NN
cord-270892-ycc3csyh	719	21	to	to	IN
cord-270892-ycc3csyh	719	22	(	(	-LRB-
cord-270892-ycc3csyh	719	23	i	i	NN
cord-270892-ycc3csyh	719	24	)	)	-RRB-
cord-270892-ycc3csyh	719	25	obtain	obtain	VB
cord-270892-ycc3csyh	719	26	insight	insight	NN
cord-270892-ycc3csyh	719	27	into	into	IN
cord-270892-ycc3csyh	719	28	the	the	DT
cord-270892-ycc3csyh	719	29	chemical	chemical	NN
cord-270892-ycc3csyh	719	30	requirements	requirement	NNS
cord-270892-ycc3csyh	719	31	mandatory	mandatory	JJ
cord-270892-ycc3csyh	719	32	for	for	IN
cord-270892-ycc3csyh	719	33	the	the	DT
cord-270892-ycc3csyh	719	34	focused	focus	VBN
cord-270892-ycc3csyh	719	35	biological	biological	JJ
cord-270892-ycc3csyh	719	36	activity	activity	NN
cord-270892-ycc3csyh	719	37	,	,	,
cord-270892-ycc3csyh	719	38	(	(	-LRB-
cord-270892-ycc3csyh	719	39	ii	ii	NN
cord-270892-ycc3csyh	719	40	)	)	-RRB-
cord-270892-ycc3csyh	719	41	improve	improve	VB
cord-270892-ycc3csyh	719	42	the	the	DT
cord-270892-ycc3csyh	719	43	compound	compound	NN
cord-270892-ycc3csyh	719	44	's	's	POS
cord-270892-ycc3csyh	719	45	pharmacological	pharmacological	JJ
cord-270892-ycc3csyh	719	46	profile	profile	NN
cord-270892-ycc3csyh	719	47	in	in	IN
cord-270892-ycc3csyh	719	48	terms	term	NNS
cord-270892-ycc3csyh	719	49	of	of	IN
cord-270892-ycc3csyh	719	50	potency	potency	NN
cord-270892-ycc3csyh	719	51	,	,	,
cord-270892-ycc3csyh	719	52	selectivity	selectivity	NN
cord-270892-ycc3csyh	719	53	,	,	,
cord-270892-ycc3csyh	719	54	cytotoxicity	cytotoxicity	NN
cord-270892-ycc3csyh	719	55	,	,	,
cord-270892-ycc3csyh	719	56	etc	etc	FW
cord-270892-ycc3csyh	719	57	.	.	FW
cord-270892-ycc3csyh	719	58	,	,	,
cord-270892-ycc3csyh	719	59	and	and	CC
cord-270892-ycc3csyh	719	60	to	to	IN
cord-270892-ycc3csyh	719	61	(	(	-LRB-
cord-270892-ycc3csyh	719	62	iii	iii	NN
cord-270892-ycc3csyh	719	63	)	)	-RRB-
cord-270892-ycc3csyh	719	64	improve	improve	VB
cord-270892-ycc3csyh	719	65	its	-PRON-	PRP$
cord-270892-ycc3csyh	719	66	bioavailability	bioavailability	NN
cord-270892-ycc3csyh	719	67	.	.	.
cord-270892-ycc3csyh	720	1	The	the	DT
cord-270892-ycc3csyh	720	2	nonphenolic	nonphenolic	JJ
cord-270892-ycc3csyh	720	3	aporphine	aporphine	JJ
cord-270892-ycc3csyh	720	4	alkaloid	alkaloid	NN
cord-270892-ycc3csyh	720	5	glaucine	glaucine	NN
cord-270892-ycc3csyh	720	6	is	be	VBZ
cord-270892-ycc3csyh	720	7	a	a	DT
cord-270892-ycc3csyh	720	8	prominent	prominent	JJ
cord-270892-ycc3csyh	720	9	constituent	constituent	NN
cord-270892-ycc3csyh	720	10	of	of	IN
cord-270892-ycc3csyh	720	11	the	the	DT
cord-270892-ycc3csyh	720	12	aerial	aerial	JJ
cord-270892-ycc3csyh	720	13	parts	part	NNS
cord-270892-ycc3csyh	720	14	of	of	IN
cord-270892-ycc3csyh	720	15	Gaucium	Gaucium	NNP
cord-270892-ycc3csyh	720	16	flavum	flavum	NNP
cord-270892-ycc3csyh	720	17	(	(	-LRB-
cord-270892-ycc3csyh	720	18	Papaveraveae	Papaveraveae	NNP
cord-270892-ycc3csyh	720	19	)	)	-RRB-
cord-270892-ycc3csyh	720	20	.	.	.
cord-270892-ycc3csyh	721	1	In	in	IN
cord-270892-ycc3csyh	721	2	a	a	DT
cord-270892-ycc3csyh	721	3	recently	recently	RB
cord-270892-ycc3csyh	721	4	published	publish	VBN
cord-270892-ycc3csyh	721	5	study	study	NN
cord-270892-ycc3csyh	721	6	,	,	,
cord-270892-ycc3csyh	721	7	Spasova	Spasova	NNP
cord-270892-ycc3csyh	721	8	et	et	NNP
cord-270892-ycc3csyh	721	9	al	al	NNP
cord-270892-ycc3csyh	721	10	.	.	NNP
cord-270892-ycc3csyh	721	11	investigated	investigate	VBD
cord-270892-ycc3csyh	721	12	the	the	DT
cord-270892-ycc3csyh	721	13	antiviral	antiviral	JJ
cord-270892-ycc3csyh	721	14	potential	potential	NN
cord-270892-ycc3csyh	721	15	of	of	IN
cord-270892-ycc3csyh	721	16	glaucine	glaucine	NN
cord-270892-ycc3csyh	721	17	(	(	-LRB-
cord-270892-ycc3csyh	721	18	Fig	Fig	NNP
cord-270892-ycc3csyh	721	19	.	.	NNP
cord-270892-ycc3csyh	721	20	5	5	CD
cord-270892-ycc3csyh	721	21	;	;	:
cord-270892-ycc3csyh	721	22	Table	Table	NNP
cord-270892-ycc3csyh	721	23	III	III	NNP
cord-270892-ycc3csyh	721	24	)	)	-RRB-
cord-270892-ycc3csyh	721	25	,	,	,
cord-270892-ycc3csyh	721	26	glaucine	glaucine	NN
cord-270892-ycc3csyh	721	27	derivatives	derivative	NNS
cord-270892-ycc3csyh	721	28	,	,	,
cord-270892-ycc3csyh	721	29	and	and	CC
cord-270892-ycc3csyh	721	30	its	-PRON-	PRP$
cord-270892-ycc3csyh	721	31	semi	semi	JJ
cord-270892-ycc3csyh	721	32	-	-	JJ
cord-270892-ycc3csyh	721	33	synthesized	synthesized	JJ
cord-270892-ycc3csyh	721	34	3-aminoethylglaucine	3-aminoethylglaucine	CD
cord-270892-ycc3csyh	721	35	cinnamoyl	cinnamoyl	NNP
cord-270892-ycc3csyh	721	36	-	-	HYPH
cord-270892-ycc3csyh	721	37	and	and	CC
cord-270892-ycc3csyh	721	38	hydroxycinnamoyl	hydroxycinnamoyl	NNP
cord-270892-ycc3csyh	721	39	amides	amide	NNS
cord-270892-ycc3csyh	721	40	.	.	.
cord-270892-ycc3csyh	722	1	Beside	beside	IN
cord-270892-ycc3csyh	722	2	the	the	DT
cord-270892-ycc3csyh	722	3	anti	anti	JJ
cord-270892-ycc3csyh	722	4	-	-	JJ
cord-270892-ycc3csyh	722	5	oxidative	oxidative	JJ
cord-270892-ycc3csyh	722	6	potential	potential	NN
cord-270892-ycc3csyh	722	7	of	of	IN
cord-270892-ycc3csyh	722	8	the	the	DT
cord-270892-ycc3csyh	722	9	newly	newly	RB
cord-270892-ycc3csyh	722	10	synthesized	synthesize	VBN
cord-270892-ycc3csyh	722	11	compounds	compound	NNS
cord-270892-ycc3csyh	722	12	,	,	,
cord-270892-ycc3csyh	722	13	they	-PRON-	PRP
cord-270892-ycc3csyh	722	14	all	all	DT
cord-270892-ycc3csyh	722	15	exerted	exert	VBD
cord-270892-ycc3csyh	722	16	an	an	DT
cord-270892-ycc3csyh	722	17	antiviral	antiviral	JJ
cord-270892-ycc3csyh	722	18	activity	activity	NN
cord-270892-ycc3csyh	722	19	against	against	IN
cord-270892-ycc3csyh	722	20	the	the	DT
cord-270892-ycc3csyh	722	21	replication	replication	NN
cord-270892-ycc3csyh	722	22	of	of	IN
cord-270892-ycc3csyh	722	23	HRV-14	HRV-14	NNP
cord-270892-ycc3csyh	722	24	.	.	.
cord-270892-ycc3csyh	723	1	The	the	DT
cord-270892-ycc3csyh	723	2	best	good	JJS
cord-270892-ycc3csyh	723	3	anti	anti	JJ
cord-270892-ycc3csyh	723	4	-	-	JJ
cord-270892-ycc3csyh	723	5	HRV	HRV	NNP
cord-270892-ycc3csyh	723	6	activity	activity	NN
cord-270892-ycc3csyh	723	7	was	be	VBD
cord-270892-ycc3csyh	723	8	observed	observe	VBN
cord-270892-ycc3csyh	723	9	for	for	IN
cord-270892-ycc3csyh	723	10	oxoglaucine	oxoglaucine	NN
cord-270892-ycc3csyh	723	11	(	(	-LRB-
cord-270892-ycc3csyh	723	12	Fig	Fig	NNP
cord-270892-ycc3csyh	723	13	.	.	NNP
cord-270892-ycc3csyh	723	14	5	5	CD
cord-270892-ycc3csyh	723	15	;	;	:
cord-270892-ycc3csyh	723	16	Table	Table	NNP
cord-270892-ycc3csyh	723	17	III	III	NNP
cord-270892-ycc3csyh	723	18	;	;	:
cord-270892-ycc3csyh	723	19	IC	IC	NNP
cord-270892-ycc3csyh	723	20	50	50	CD
cord-270892-ycc3csyh	723	21	Table	Table	NNP
cord-270892-ycc3csyh	723	22	III	III	NNP
cord-270892-ycc3csyh	723	23	;	;	:
cord-270892-ycc3csyh	723	24	IC	IC	NNP
cord-270892-ycc3csyh	723	25	50	50	CD
cord-270892-ycc3csyh	723	26	15	15	CD
cord-270892-ycc3csyh	723	27	mM	mm	NN
cord-270892-ycc3csyh	723	28	,	,	,
cord-270892-ycc3csyh	723	29	SI	SI	NNP
cord-270892-ycc3csyh	723	30	10.3	10.3	CD
cord-270892-ycc3csyh	723	31	and	and	CC
cord-270892-ycc3csyh	723	32	IC	IC	NNP
cord-270892-ycc3csyh	723	33	50	50	CD
cord-270892-ycc3csyh	723	34	13	13	CD
cord-270892-ycc3csyh	723	35	mM	mm	CD
cord-270892-ycc3csyh	723	36	,	,	,
cord-270892-ycc3csyh	723	37	SI	SI	NNP
cord-270892-ycc3csyh	723	38	11	11	CD
cord-270892-ycc3csyh	723	39	,	,	,
cord-270892-ycc3csyh	723	40	respectively	respectively	RB
cord-270892-ycc3csyh	723	41	)	)	-RRB-
cord-270892-ycc3csyh	723	42	.	.	.
cord-270892-ycc3csyh	724	1	327	327	CD
cord-270892-ycc3csyh	725	1	The	the	DT
cord-270892-ycc3csyh	725	2	early	early	JJ
cord-270892-ycc3csyh	725	3	findings	finding	NNS
cord-270892-ycc3csyh	725	4	of	of	IN
cord-270892-ycc3csyh	725	5	the	the	DT
cord-270892-ycc3csyh	725	6	anti	anti	JJ
cord-270892-ycc3csyh	725	7	-	-	JJ
cord-270892-ycc3csyh	725	8	HRV	HRV	NNP
cord-270892-ycc3csyh	725	9	active	active	JJ
cord-270892-ycc3csyh	725	10	naturally	naturally	RB
cord-270892-ycc3csyh	725	11	derived	derive	VBN
cord-270892-ycc3csyh	725	12	3-methoxyflavone	3-methoxyflavone	CD
cord-270892-ycc3csyh	725	13	inspired	inspire	VBN
cord-270892-ycc3csyh	725	14	chemists	chemist	NNS
cord-270892-ycc3csyh	725	15	and	and	CC
cord-270892-ycc3csyh	725	16	pharmacologists	pharmacologist	NNS
cord-270892-ycc3csyh	725	17	in	in	IN
cord-270892-ycc3csyh	725	18	the	the	DT
cord-270892-ycc3csyh	725	19	synthesis	synthesis	NN
cord-270892-ycc3csyh	725	20	and	and	CC
cord-270892-ycc3csyh	725	21	the	the	DT
cord-270892-ycc3csyh	725	22	pharmacological	pharmacological	JJ
cord-270892-ycc3csyh	725	23	evaluation	evaluation	NN
cord-270892-ycc3csyh	725	24	of	of	IN
cord-270892-ycc3csyh	725	25	derivatives	derivative	NNS
cord-270892-ycc3csyh	725	26	thereof	thereof	RB
cord-270892-ycc3csyh	725	27	decorated	decorate	VBN
cord-270892-ycc3csyh	725	28	with	with	IN
cord-270892-ycc3csyh	725	29	various	various	JJ
cord-270892-ycc3csyh	725	30	substitution	substitution	NN
cord-270892-ycc3csyh	725	31	patterns	pattern	NNS
cord-270892-ycc3csyh	725	32	.	.	.
cord-270892-ycc3csyh	726	1	Several	several	JJ
cord-270892-ycc3csyh	726	2	reports	report	NNS
cord-270892-ycc3csyh	726	3	published	publish	VBN
cord-270892-ycc3csyh	726	4	during	during	IN
cord-270892-ycc3csyh	726	5	the	the	DT
cord-270892-ycc3csyh	726	6	last	last	JJ
cord-270892-ycc3csyh	726	7	two	two	CD
cord-270892-ycc3csyh	726	8	decades	decade	NNS
cord-270892-ycc3csyh	726	9	reviewed	review	VBD
cord-270892-ycc3csyh	726	10	the	the	DT
cord-270892-ycc3csyh	726	11	findings	finding	NNS
cord-270892-ycc3csyh	726	12	of	of	IN
cord-270892-ycc3csyh	726	13	antiviral	antiviral	JJ
cord-270892-ycc3csyh	726	14	flavonoid	flavonoid	NN
cord-270892-ycc3csyh	726	15	research	research	NN
cord-270892-ycc3csyh	726	16	.	.	.
cord-270892-ycc3csyh	727	1	320	320	CD
cord-270892-ycc3csyh	727	2	,	,	,
cord-270892-ycc3csyh	727	3	328	328	CD
cord-270892-ycc3csyh	727	4	,	,	,
cord-270892-ycc3csyh	727	5	329	329	CD
cord-270892-ycc3csyh	728	1	By	by	IN
cord-270892-ycc3csyh	728	2	investigating	investigate	VBG
cord-270892-ycc3csyh	728	3	the	the	DT
cord-270892-ycc3csyh	728	4	antiviral	antiviral	JJ
cord-270892-ycc3csyh	728	5	activity	activity	NN
cord-270892-ycc3csyh	728	6	of	of	IN
cord-270892-ycc3csyh	728	7	a	a	DT
cord-270892-ycc3csyh	728	8	wide	wide	JJ
cord-270892-ycc3csyh	728	9	variety	variety	NN
cord-270892-ycc3csyh	728	10	of	of	IN
cord-270892-ycc3csyh	728	11	naturally	naturally	RB
cord-270892-ycc3csyh	728	12	occurring	occur	VBG
cord-270892-ycc3csyh	728	13	flavonoids	flavonoid	NNS
cord-270892-ycc3csyh	728	14	,	,	,
cord-270892-ycc3csyh	728	15	Tsuchiya	Tsuchiya	NNP
cord-270892-ycc3csyh	728	16	et	et	NNP
cord-270892-ycc3csyh	728	17	al	al	NNP
cord-270892-ycc3csyh	728	18	.	.	.
cord-270892-ycc3csyh	729	1	found	find	VBD
cord-270892-ycc3csyh	729	2	chrysosplenol	chrysosplenol	NNP
cord-270892-ycc3csyh	729	3	B	B	NNP
cord-270892-ycc3csyh	729	4	and	and	CC
cord-270892-ycc3csyh	729	5	C	C	NNP
cord-270892-ycc3csyh	730	1	(	(	-LRB-
cord-270892-ycc3csyh	730	2	Fig	Fig	NNP
cord-270892-ycc3csyh	730	3	.	.	.
cord-270892-ycc3csyh	731	1	5	5	LS
cord-270892-ycc3csyh	731	2	;	;	:
cord-270892-ycc3csyh	731	3	Table	Table	NNP
cord-270892-ycc3csyh	731	4	III	iii	CD
cord-270892-ycc3csyh	731	5	)	)	-RRB-
cord-270892-ycc3csyh	732	1	contained	contain	VBN
cord-270892-ycc3csyh	732	2	in	in	IN
cord-270892-ycc3csyh	732	3	Chrysosplenium	Chrysosplenium	NNP
cord-270892-ycc3csyh	732	4	plants	plant	NNS
cord-270892-ycc3csyh	732	5	,	,	,
cord-270892-ycc3csyh	732	6	and	and	CC
cord-270892-ycc3csyh	732	7	axillarin	axillarin	NNP
cord-270892-ycc3csyh	732	8	(	(	-LRB-
cord-270892-ycc3csyh	732	9	Fig	Fig	NNP
cord-270892-ycc3csyh	732	10	.	.	NNP
cord-270892-ycc3csyh	732	11	5	5	CD
cord-270892-ycc3csyh	732	12	;	;	:
cord-270892-ycc3csyh	732	13	Table	Table	NNP
cord-270892-ycc3csyh	732	14	III	III	NNP
cord-270892-ycc3csyh	732	15	)	)	-RRB-
cord-270892-ycc3csyh	732	16	as	as	IN
cord-270892-ycc3csyh	732	17	potent	potent	JJ
cord-270892-ycc3csyh	732	18	anti	anti	JJ
cord-270892-ycc3csyh	732	19	-	-	JJ
cord-270892-ycc3csyh	732	20	HRV	HRV	NNP
cord-270892-ycc3csyh	732	21	agents	agent	NNS
cord-270892-ycc3csyh	732	22	.	.	.
cord-270892-ycc3csyh	733	1	Based	base	VBN
cord-270892-ycc3csyh	733	2	on	on	IN
cord-270892-ycc3csyh	733	3	their	-PRON-	PRP$
cord-270892-ycc3csyh	733	4	findings	finding	NNS
cord-270892-ycc3csyh	733	5	,	,	,
cord-270892-ycc3csyh	733	6	the	the	DT
cord-270892-ycc3csyh	733	7	flavone	flavone	NNP
cord-270892-ycc3csyh	733	8	skeleton	skeleton	NN
cord-270892-ycc3csyh	733	9	decorated	decorate	VBN
cord-270892-ycc3csyh	733	10	with	with	IN
cord-270892-ycc3csyh	733	11	a	a	DT
cord-270892-ycc3csyh	733	12	methoxy	methoxy	JJ
cord-270892-ycc3csyh	733	13	group	group	NN
cord-270892-ycc3csyh	733	14	in	in	IN
cord-270892-ycc3csyh	733	15	position	position	NN
cord-270892-ycc3csyh	733	16	3	3	CD
cord-270892-ycc3csyh	733	17	and	and	CC
cord-270892-ycc3csyh	733	18	a	a	DT
cord-270892-ycc3csyh	733	19	5-hydroxyl	5-hydroxyl	CD
cord-270892-ycc3csyh	733	20	group	group	NN
cord-270892-ycc3csyh	733	21	revealed	reveal	VBD
cord-270892-ycc3csyh	733	22	as	as	IN
cord-270892-ycc3csyh	733	23	mandatory	mandatory	JJ
cord-270892-ycc3csyh	733	24	for	for	IN
cord-270892-ycc3csyh	733	25	an	an	DT
cord-270892-ycc3csyh	733	26	anti	anti	JJ
cord-270892-ycc3csyh	733	27	-	-	JJ
cord-270892-ycc3csyh	733	28	HRV	HRV	NNP
cord-270892-ycc3csyh	733	29	activity	activity	NN
cord-270892-ycc3csyh	733	30	.	.	.
cord-270892-ycc3csyh	734	1	319	319	CD
cord-270892-ycc3csyh	735	1	A	a	DT
cord-270892-ycc3csyh	735	2	series	series	NN
cord-270892-ycc3csyh	735	3	of	of	IN
cord-270892-ycc3csyh	735	4	antipicornaviral	antipicornaviral	NNP
cord-270892-ycc3csyh	735	5	4	4	CD
cord-270892-ycc3csyh	735	6	0	0	CD
cord-270892-ycc3csyh	736	1	-hydroxy-3-methoxyflavone	-hydroxy-3-methoxyflavone	CD
cord-270892-ycc3csyh	736	2	derivatives	derivative	NNS
cord-270892-ycc3csyh	736	3	was	be	VBD
cord-270892-ycc3csyh	736	4	synthesized	synthesize	VBN
cord-270892-ycc3csyh	736	5	by	by	IN
cord-270892-ycc3csyh	736	6	De	De	NNP
cord-270892-ycc3csyh	736	7	Meyer	Meyer	NNP
cord-270892-ycc3csyh	736	8	et	et	NNP
cord-270892-ycc3csyh	736	9	al	al	NNP
cord-270892-ycc3csyh	736	10	.	.	.
cord-270892-ycc3csyh	737	1	in	in	IN
cord-270892-ycc3csyh	737	2	order	order	NN
cord-270892-ycc3csyh	737	3	to	to	TO
cord-270892-ycc3csyh	737	4	establish	establish	VB
cord-270892-ycc3csyh	737	5	a	a	DT
cord-270892-ycc3csyh	737	6	structure	structure	NN
cord-270892-ycc3csyh	737	7	-	-	HYPH
cord-270892-ycc3csyh	737	8	activity	activity	NN
cord-270892-ycc3csyh	737	9	relationship	relationship	NN
cord-270892-ycc3csyh	737	10	.	.	.
cord-270892-ycc3csyh	738	1	Thereby	thereby	RB
cord-270892-ycc3csyh	738	2	,	,	,
cord-270892-ycc3csyh	738	3	different	different	JJ
cord-270892-ycc3csyh	738	4	substitution	substitution	NN
cord-270892-ycc3csyh	738	5	patterns	pattern	NNS
cord-270892-ycc3csyh	738	6	of	of	IN
cord-270892-ycc3csyh	738	7	the	the	DT
cord-270892-ycc3csyh	738	8	A	a	RB
cord-270892-ycc3csyh	738	9	-	-	HYPH
cord-270892-ycc3csyh	738	10	ring	ring	NN
cord-270892-ycc3csyh	738	11	system	system	NN
cord-270892-ycc3csyh	738	12	with	with	IN
cord-270892-ycc3csyh	738	13	methyl	methyl	NN
cord-270892-ycc3csyh	738	14	,	,	,
cord-270892-ycc3csyh	738	15	hydroxy	hydroxy	NN
cord-270892-ycc3csyh	738	16	,	,	,
cord-270892-ycc3csyh	738	17	methoxy	methoxy	NN
cord-270892-ycc3csyh	738	18	,	,	,
cord-270892-ycc3csyh	738	19	halo	halo	NN
cord-270892-ycc3csyh	738	20	,	,	,
cord-270892-ycc3csyh	738	21	nitro	nitro	NN
cord-270892-ycc3csyh	738	22	,	,	,
cord-270892-ycc3csyh	738	23	and	and	CC
cord-270892-ycc3csyh	738	24	amino	amino	NNS
cord-270892-ycc3csyh	738	25	was	be	VBD
cord-270892-ycc3csyh	738	26	performed	perform	VBN
cord-270892-ycc3csyh	738	27	.	.	.
cord-270892-ycc3csyh	739	1	Their	-PRON-	PRP$
cord-270892-ycc3csyh	739	2	activity	activity	NN
cord-270892-ycc3csyh	739	3	against	against	IN
cord-270892-ycc3csyh	739	4	polio	polio	NN
cord-270892-ycc3csyh	739	5	and	and	CC
cord-270892-ycc3csyh	739	6	HRV	HRV	NNP
cord-270892-ycc3csyh	739	7	was	be	VBD
cord-270892-ycc3csyh	739	8	compared	compare	VBN
cord-270892-ycc3csyh	739	9	with	with	IN
cord-270892-ycc3csyh	739	10	those	those	DT
cord-270892-ycc3csyh	739	11	of	of	IN
cord-270892-ycc3csyh	739	12	naturally	naturally	RB
cord-270892-ycc3csyh	739	13	occurring	occur	VBG
cord-270892-ycc3csyh	739	14	flavonoids	flavonoid	NNS
cord-270892-ycc3csyh	739	15	.	.	.
cord-270892-ycc3csyh	740	1	Further	further	RB
cord-270892-ycc3csyh	740	2	,	,	,
cord-270892-ycc3csyh	740	3	the	the	DT
cord-270892-ycc3csyh	740	4	importance	importance	NN
cord-270892-ycc3csyh	740	5	of	of	IN
cord-270892-ycc3csyh	740	6	the	the	DT
cord-270892-ycc3csyh	740	7	4	4	CD
cord-270892-ycc3csyh	740	8	0	0	CD
cord-270892-ycc3csyh	740	9	hydroxyl	hydroxyl	NN
cord-270892-ycc3csyh	740	10	-	-	HYPH
cord-270892-ycc3csyh	740	11	group	group	NN
cord-270892-ycc3csyh	740	12	and	and	CC
cord-270892-ycc3csyh	740	13	of	of	IN
cord-270892-ycc3csyh	740	14	the	the	DT
cord-270892-ycc3csyh	740	15	3-methoxyl	3-methoxyl	CD
cord-270892-ycc3csyh	740	16	-	-	HYPH
cord-270892-ycc3csyh	740	17	group	group	NN
cord-270892-ycc3csyh	740	18	was	be	VBD
cord-270892-ycc3csyh	740	19	confirmed	confirm	VBN
cord-270892-ycc3csyh	740	20	by	by	IN
cord-270892-ycc3csyh	740	21	investigation	investigation	NN
cord-270892-ycc3csyh	740	22	of	of	IN
cord-270892-ycc3csyh	740	23	different	different	JJ
cord-270892-ycc3csyh	740	24	derivatives	derivative	NNS
cord-270892-ycc3csyh	740	25	lacking	lack	VBG
cord-270892-ycc3csyh	740	26	these	these	DT
cord-270892-ycc3csyh	740	27	features	feature	NNS
cord-270892-ycc3csyh	740	28	.	.	.
cord-270892-ycc3csyh	741	1	321	321	CD
cord-270892-ycc3csyh	742	1	The	the	DT
cord-270892-ycc3csyh	742	2	results	result	NNS
cord-270892-ycc3csyh	742	3	showed	show	VBD
cord-270892-ycc3csyh	742	4	that	that	IN
cord-270892-ycc3csyh	742	5	4	4	CD
cord-270892-ycc3csyh	742	6	0	0	CD
cord-270892-ycc3csyh	742	7	-hydroxy-3-methoxyflavones	-hydroxy-3-methoxyflavones	:
cord-270892-ycc3csyh	742	8	with	with	IN
cord-270892-ycc3csyh	742	9	a	a	DT
cord-270892-ycc3csyh	742	10	monosubstituted	monosubstituted	JJ
cord-270892-ycc3csyh	742	11	A	a	NN
cord-270892-ycc3csyh	742	12	-	-	HYPH
cord-270892-ycc3csyh	742	13	ring	ring	NN
cord-270892-ycc3csyh	742	14	are	be	VBP
cord-270892-ycc3csyh	742	15	less	less	RBR
cord-270892-ycc3csyh	742	16	active	active	JJ
cord-270892-ycc3csyh	742	17	than	than	IN
cord-270892-ycc3csyh	742	18	the	the	DT
cord-270892-ycc3csyh	742	19	corresponding	correspond	VBG
cord-270892-ycc3csyh	742	20	compounds	compound	NNS
cord-270892-ycc3csyh	742	21	having	have	VBG
cord-270892-ycc3csyh	742	22	a	a	DT
cord-270892-ycc3csyh	742	23	polysubstituted	polysubstitute	VBN
cord-270892-ycc3csyh	742	24	A	a	NN
cord-270892-ycc3csyh	742	25	-	-	HYPH
cord-270892-ycc3csyh	742	26	ring	ring	NN
cord-270892-ycc3csyh	742	27	.	.	.
cord-270892-ycc3csyh	743	1	Within	within	IN
cord-270892-ycc3csyh	743	2	the	the	DT
cord-270892-ycc3csyh	743	3	tested	test	VBN
cord-270892-ycc3csyh	743	4	series	series	NN
cord-270892-ycc3csyh	743	5	of	of	IN
cord-270892-ycc3csyh	743	6	compounds	compound	NNS
cord-270892-ycc3csyh	743	7	,	,	,
cord-270892-ycc3csyh	743	8	4	4	CD
cord-270892-ycc3csyh	743	9	0	0	CD
cord-270892-ycc3csyh	743	10	,	,	,
cord-270892-ycc3csyh	743	11	7-dihydroxy-3-methoxy-5,6-dimethylflavone	7-dihydroxy-3-methoxy-5,6-dimethylflavone	CD
cord-270892-ycc3csyh	743	12	emerged	emerge	VBD
cord-270892-ycc3csyh	743	13	not	not	RB
cord-270892-ycc3csyh	743	14	only	only	RB
cord-270892-ycc3csyh	743	15	as	as	IN
cord-270892-ycc3csyh	743	16	noncytotoxic	noncytotoxic	NNP
cord-270892-ycc3csyh	743	17	but	but	CC
cord-270892-ycc3csyh	743	18	also	also	RB
cord-270892-ycc3csyh	743	19	as	as	IN
cord-270892-ycc3csyh	743	20	most	most	RBS
cord-270892-ycc3csyh	743	21	potent	potent	JJ
cord-270892-ycc3csyh	743	22	substance	substance	NN
cord-270892-ycc3csyh	743	23	in	in	IN
cord-270892-ycc3csyh	743	24	both	both	DT
cord-270892-ycc3csyh	743	25	antiviral	antiviral	JJ
cord-270892-ycc3csyh	743	26	test	test	NN
cord-270892-ycc3csyh	743	27	systems	system	NNS
cord-270892-ycc3csyh	743	28	.	.	.
cord-270892-ycc3csyh	744	1	The	the	DT
cord-270892-ycc3csyh	744	2	lowest	low	JJS
cord-270892-ycc3csyh	744	3	concentrations	concentration	NNS
cord-270892-ycc3csyh	744	4	for	for	IN
cord-270892-ycc3csyh	744	5	this	this	DT
cord-270892-ycc3csyh	744	6	compound	compound	NN
cord-270892-ycc3csyh	744	7	that	that	WDT
cord-270892-ycc3csyh	744	8	protect	protect	VBP
cord-270892-ycc3csyh	744	9	50	50	CD
cord-270892-ycc3csyh	744	10	%	%	NN
cord-270892-ycc3csyh	744	11	of	of	IN
cord-270892-ycc3csyh	744	12	the	the	DT
cord-270892-ycc3csyh	744	13	cells	cell	NNS
cord-270892-ycc3csyh	744	14	from	from	IN
cord-270892-ycc3csyh	744	15	CPE	CPE	NNP
cord-270892-ycc3csyh	744	16	of	of	IN
cord-270892-ycc3csyh	744	17	12	12	CD
cord-270892-ycc3csyh	744	18	HRV	HRV	NNP
cord-270892-ycc3csyh	744	19	serotypes	serotype	NNS
cord-270892-ycc3csyh	744	20	were	be	VBD
cord-270892-ycc3csyh	744	21	in	in	IN
cord-270892-ycc3csyh	744	22	the	the	DT
cord-270892-ycc3csyh	744	23	range	range	NN
cord-270892-ycc3csyh	744	24	from	from	IN
cord-270892-ycc3csyh	744	25	0.016	0.016	CD
cord-270892-ycc3csyh	744	26	to	to	IN
cord-270892-ycc3csyh	744	27	0.5	0.5	CD
cord-270892-ycc3csyh	744	28	mg	mg	NNP
cord-270892-ycc3csyh	744	29	/	/	SYM
cord-270892-ycc3csyh	744	30	mL.	mL.	NNP
cord-270892-ycc3csyh	745	1	In	in	IN
cord-270892-ycc3csyh	745	2	contrast	contrast	NN
cord-270892-ycc3csyh	745	3	to	to	IN
cord-270892-ycc3csyh	745	4	quercetin	quercetin	NN
cord-270892-ycc3csyh	745	5	,	,	,
cord-270892-ycc3csyh	745	6	this	this	DT
cord-270892-ycc3csyh	745	7	flavone	flavone	NN
cord-270892-ycc3csyh	745	8	was	be	VBD
cord-270892-ycc3csyh	745	9	also	also	RB
cord-270892-ycc3csyh	745	10	reported	report	VBN
cord-270892-ycc3csyh	745	11	to	to	TO
cord-270892-ycc3csyh	745	12	have	have	VB
cord-270892-ycc3csyh	745	13	no	no	DT
cord-270892-ycc3csyh	745	14	mutagenic	mutagenic	JJ
cord-270892-ycc3csyh	745	15	properties	property	NNS
cord-270892-ycc3csyh	745	16	(	(	-LRB-
cord-270892-ycc3csyh	745	17	measured	measure	VBN
cord-270892-ycc3csyh	745	18	up	up	RP
cord-270892-ycc3csyh	745	19	to	to	IN
cord-270892-ycc3csyh	745	20	2.5	2.5	CD
cord-270892-ycc3csyh	745	21	mg	mg	NNP
cord-270892-ycc3csyh	745	22	/	/	SYM
cord-270892-ycc3csyh	745	23	plate	plate	NN
cord-270892-ycc3csyh	745	24	)	)	-RRB-
cord-270892-ycc3csyh	745	25	in	in	IN
cord-270892-ycc3csyh	745	26	a	a	DT
cord-270892-ycc3csyh	745	27	short	short	JJ
cord-270892-ycc3csyh	745	28	-	-	HYPH
cord-270892-ycc3csyh	745	29	term	term	NN
cord-270892-ycc3csyh	745	30	microbial	microbial	JJ
cord-270892-ycc3csyh	745	31	assay	assay	NN
cord-270892-ycc3csyh	745	32	.	.	.
cord-270892-ycc3csyh	746	1	321	321	CD
cord-270892-ycc3csyh	747	1	The	the	DT
cord-270892-ycc3csyh	747	2	mechanism	mechanism	NN
cord-270892-ycc3csyh	747	3	studies	study	NNS
cord-270892-ycc3csyh	747	4	performed	perform	VBN
cord-270892-ycc3csyh	747	5	with	with	IN
cord-270892-ycc3csyh	747	6	3-methoxyflavones	3-methoxyflavones	CD
cord-270892-ycc3csyh	747	7	have	have	VBP
cord-270892-ycc3csyh	747	8	shown	show	VBN
cord-270892-ycc3csyh	747	9	an	an	DT
cord-270892-ycc3csyh	747	10	interference	interference	NN
cord-270892-ycc3csyh	747	11	with	with	IN
cord-270892-ycc3csyh	747	12	an	an	DT
cord-270892-ycc3csyh	747	13	early	early	JJ
cord-270892-ycc3csyh	747	14	stage	stage	NN
cord-270892-ycc3csyh	747	15	in	in	IN
cord-270892-ycc3csyh	747	16	the	the	DT
cord-270892-ycc3csyh	747	17	viral	viral	JJ
cord-270892-ycc3csyh	747	18	RNA	RNA	NNP
cord-270892-ycc3csyh	747	19	synthesis	synthesis	NN
cord-270892-ycc3csyh	747	20	;	;	:
cord-270892-ycc3csyh	747	21	no	no	DT
cord-270892-ycc3csyh	747	22	induction	induction	NN
cord-270892-ycc3csyh	747	23	of	of	IN
cord-270892-ycc3csyh	747	24	resistance	resistance	NN
cord-270892-ycc3csyh	747	25	was	be	VBD
cord-270892-ycc3csyh	747	26	observed	observe	VBN
cord-270892-ycc3csyh	747	27	.	.	.
cord-270892-ycc3csyh	748	1	320	320	CD
cord-270892-ycc3csyh	749	1	In	in	IN
cord-270892-ycc3csyh	749	2	contrast	contrast	NN
cord-270892-ycc3csyh	749	3	to	to	IN
cord-270892-ycc3csyh	749	4	this	this	DT
cord-270892-ycc3csyh	749	5	mode	mode	NN
cord-270892-ycc3csyh	749	6	of	of	IN
cord-270892-ycc3csyh	749	7	action	action	NN
cord-270892-ycc3csyh	749	8	,	,	,
cord-270892-ycc3csyh	749	9	the	the	DT
cord-270892-ycc3csyh	749	10	anti	anti	JJ
cord-270892-ycc3csyh	749	11	-	-	JJ
cord-270892-ycc3csyh	749	12	HRV	HRV	NNP
cord-270892-ycc3csyh	749	13	chalcones	chalcone	NNS
cord-270892-ycc3csyh	749	14	and	and	CC
cord-270892-ycc3csyh	749	15	flavans	flavans	NNPS
cord-270892-ycc3csyh	749	16	are	be	VBP
cord-270892-ycc3csyh	749	17	reported	report	VBN
cord-270892-ycc3csyh	749	18	to	to	TO
cord-270892-ycc3csyh	749	19	interact	interact	VB
cord-270892-ycc3csyh	749	20	directly	directly	RB
cord-270892-ycc3csyh	749	21	with	with	IN
cord-270892-ycc3csyh	749	22	specific	specific	JJ
cord-270892-ycc3csyh	749	23	sites	site	NNS
cord-270892-ycc3csyh	749	24	on	on	IN
cord-270892-ycc3csyh	749	25	the	the	DT
cord-270892-ycc3csyh	749	26	viral	viral	JJ
cord-270892-ycc3csyh	749	27	capsid	capsid	NN
cord-270892-ycc3csyh	749	28	proteins	protein	NNS
cord-270892-ycc3csyh	749	29	,	,	,
cord-270892-ycc3csyh	749	30	thereby	thereby	RB
cord-270892-ycc3csyh	749	31	preventing	prevent	VBG
cord-270892-ycc3csyh	749	32	uncoating	uncoating	NN
cord-270892-ycc3csyh	749	33	and	and	CC
cord-270892-ycc3csyh	749	34	the	the	DT
cord-270892-ycc3csyh	749	35	consequent	consequent	JJ
cord-270892-ycc3csyh	749	36	liberation	liberation	NN
cord-270892-ycc3csyh	749	37	of	of	IN
cord-270892-ycc3csyh	749	38	viral	viral	JJ
cord-270892-ycc3csyh	749	39	RNA	RNA	NNP
cord-270892-ycc3csyh	749	40	.	.	.
cord-270892-ycc3csyh	750	1	193	193	CD
cord-270892-ycc3csyh	750	2	,	,	,
cord-270892-ycc3csyh	750	3	330	330	CD
cord-270892-ycc3csyh	750	4	,	,	,
cord-270892-ycc3csyh	750	5	331	331	CD
cord-270892-ycc3csyh	751	1	Due	due	IN
cord-270892-ycc3csyh	751	2	to	to	IN
cord-270892-ycc3csyh	751	3	its	-PRON-	PRP$
cord-270892-ycc3csyh	751	4	anti	anti	JJ
cord-270892-ycc3csyh	751	5	-	-	JJ
cord-270892-ycc3csyh	751	6	HRV	HRV	NNP
cord-270892-ycc3csyh	751	7	potency	potency	NN
cord-270892-ycc3csyh	751	8	,	,	,
cord-270892-ycc3csyh	751	9	low	low	JJ
cord-270892-ycc3csyh	751	10	toxicity	toxicity	NN
cord-270892-ycc3csyh	751	11	,	,	,
cord-270892-ycc3csyh	751	12	and	and	CC
cord-270892-ycc3csyh	751	13	promising	promising	JJ
cord-270892-ycc3csyh	751	14	bioavailability	bioavailability	NN
cord-270892-ycc3csyh	751	15	,	,	,
cord-270892-ycc3csyh	751	16	dichloroflavan	dichloroflavan	NNP
cord-270892-ycc3csyh	751	17	was	be	VBD
cord-270892-ycc3csyh	751	18	evaluated	evaluate	VBN
cord-270892-ycc3csyh	751	19	for	for	IN
cord-270892-ycc3csyh	751	20	its	-PRON-	PRP$
cord-270892-ycc3csyh	751	21	protective	protective	JJ
cord-270892-ycc3csyh	751	22	efficacy	efficacy	NN
cord-270892-ycc3csyh	751	23	against	against	IN
cord-270892-ycc3csyh	751	24	experimental	experimental	JJ
cord-270892-ycc3csyh	751	25	HRV	HRV	NNP
cord-270892-ycc3csyh	751	26	-	-	HYPH
cord-270892-ycc3csyh	751	27	infection	infection	NN
cord-270892-ycc3csyh	751	28	in	in	IN
cord-270892-ycc3csyh	751	29	two	two	CD
cord-270892-ycc3csyh	751	30	clinical	clinical	JJ
cord-270892-ycc3csyh	751	31	,	,	,
cord-270892-ycc3csyh	751	32	double	double	JJ
cord-270892-ycc3csyh	751	33	-	-	HYPH
cord-270892-ycc3csyh	751	34	blind	blind	JJ
cord-270892-ycc3csyh	751	35	,	,	,
cord-270892-ycc3csyh	751	36	placebo	placebo	NN
cord-270892-ycc3csyh	751	37	-	-	HYPH
cord-270892-ycc3csyh	751	38	controlled	control	VBN
cord-270892-ycc3csyh	751	39	trials	trial	NNS
cord-270892-ycc3csyh	751	40	.	.	.
cord-270892-ycc3csyh	752	1	However	however	RB
cord-270892-ycc3csyh	752	2	,	,	,
cord-270892-ycc3csyh	752	3	the	the	DT
cord-270892-ycc3csyh	752	4	drug	drug	NN
cord-270892-ycc3csyh	752	5	candidate	candidate	NN
cord-270892-ycc3csyh	752	6	failed	fail	VBD
cord-270892-ycc3csyh	752	7	either	either	CC
cord-270892-ycc3csyh	752	8	when	when	WRB
cord-270892-ycc3csyh	752	9	administered	administer	VBN
cord-270892-ycc3csyh	752	10	orally	orally	RB
cord-270892-ycc3csyh	752	11	or	or	CC
cord-270892-ycc3csyh	752	12	intranasally	intranasally	RB
cord-270892-ycc3csyh	752	13	.	.	.
cord-270892-ycc3csyh	753	1	332	332	CD
cord-270892-ycc3csyh	753	2	,	,	,
cord-270892-ycc3csyh	753	3	333	333	CD
cord-270892-ycc3csyh	753	4	Unfortunately	unfortunately	RB
cord-270892-ycc3csyh	753	5	,	,	,
cord-270892-ycc3csyh	753	6	till	till	IN
cord-270892-ycc3csyh	753	7	now	now	RB
cord-270892-ycc3csyh	753	8	no	no	DT
cord-270892-ycc3csyh	753	9	clinical	clinical	JJ
cord-270892-ycc3csyh	753	10	trials	trial	NNS
cord-270892-ycc3csyh	753	11	evaluating	evaluate	VBG
cord-270892-ycc3csyh	753	12	the	the	DT
cord-270892-ycc3csyh	753	13	efficacy	efficacy	NN
cord-270892-ycc3csyh	753	14	of	of	IN
cord-270892-ycc3csyh	753	15	3-methoxyflavones	3-methoxyflavones	CD
cord-270892-ycc3csyh	753	16	in	in	IN
cord-270892-ycc3csyh	753	17	common	common	JJ
cord-270892-ycc3csyh	753	18	cold	cold	NN
cord-270892-ycc3csyh	753	19	have	have	VBP
cord-270892-ycc3csyh	753	20	been	be	VBN
cord-270892-ycc3csyh	753	21	performed	perform	VBN
cord-270892-ycc3csyh	753	22	.	.	.
cord-270892-ycc3csyh	754	1	The	the	DT
cord-270892-ycc3csyh	754	2	common	common	JJ
cord-270892-ycc3csyh	754	3	idea	idea	NN
cord-270892-ycc3csyh	754	4	of	of	IN
cord-270892-ycc3csyh	754	5	all	all	DT
cord-270892-ycc3csyh	754	6	computational	computational	JJ
cord-270892-ycc3csyh	754	7	approaches	approach	NNS
cord-270892-ycc3csyh	754	8	is	be	VBZ
cord-270892-ycc3csyh	754	9	to	to	TO
cord-270892-ycc3csyh	754	10	extract	extract	VB
cord-270892-ycc3csyh	754	11	knowledge	knowledge	NN
cord-270892-ycc3csyh	754	12	from	from	IN
cord-270892-ycc3csyh	754	13	a	a	DT
cord-270892-ycc3csyh	754	14	more	more	RBR
cord-270892-ycc3csyh	754	15	or	or	CC
cord-270892-ycc3csyh	754	16	less	less	RBR
cord-270892-ycc3csyh	754	17	large	large	JJ
cord-270892-ycc3csyh	754	18	set	set	NN
cord-270892-ycc3csyh	754	19	of	of	IN
cord-270892-ycc3csyh	754	20	data	datum	NNS
cord-270892-ycc3csyh	754	21	in	in	IN
cord-270892-ycc3csyh	754	22	order	order	NN
cord-270892-ycc3csyh	754	23	to	to	TO
cord-270892-ycc3csyh	754	24	make	make	VB
cord-270892-ycc3csyh	754	25	predictions	prediction	NNS
cord-270892-ycc3csyh	754	26	of	of	IN
cord-270892-ycc3csyh	754	27	new	new	JJ
cord-270892-ycc3csyh	754	28	events	event	NNS
cord-270892-ycc3csyh	754	29	.	.	.
cord-270892-ycc3csyh	755	1	334	334	CD
cord-270892-ycc3csyh	756	1	Within	within	IN
cord-270892-ycc3csyh	756	2	the	the	DT
cord-270892-ycc3csyh	756	3	lead	lead	JJ
cord-270892-ycc3csyh	756	4	discovery	discovery	NN
cord-270892-ycc3csyh	756	5	process	process	NN
cord-270892-ycc3csyh	756	6	,	,	,
cord-270892-ycc3csyh	756	7	computational	computational	JJ
cord-270892-ycc3csyh	756	8	approaches	approach	NNS
cord-270892-ycc3csyh	756	9	,	,	,
cord-270892-ycc3csyh	756	10	such	such	JJ
cord-270892-ycc3csyh	756	11	as	as	IN
cord-270892-ycc3csyh	756	12	virtual	virtual	JJ
cord-270892-ycc3csyh	756	13	screening	screening	NN
cord-270892-ycc3csyh	756	14	,	,	,
cord-270892-ycc3csyh	756	15	docking	docking	NN
cord-270892-ycc3csyh	756	16	,	,	,
cord-270892-ycc3csyh	756	17	quantitative	quantitative	JJ
cord-270892-ycc3csyh	756	18	structure	structure	NN
cord-270892-ycc3csyh	756	19	-	-	HYPH
cord-270892-ycc3csyh	756	20	activity	activity	NN
cord-270892-ycc3csyh	756	21	relationship	relationship	NN
cord-270892-ycc3csyh	756	22	,	,	,
cord-270892-ycc3csyh	756	23	have	have	VBP
cord-270892-ycc3csyh	756	24	largely	largely	RB
cord-270892-ycc3csyh	756	25	enhanced	enhance	VBN
cord-270892-ycc3csyh	756	26	the	the	DT
cord-270892-ycc3csyh	756	27	impact	impact	NN
cord-270892-ycc3csyh	756	28	of	of	IN
cord-270892-ycc3csyh	756	29	computational	computational	JJ
cord-270892-ycc3csyh	756	30	chemistry	chemistry	NN
cord-270892-ycc3csyh	756	31	and	and	CC
cord-270892-ycc3csyh	756	32	nowadays	nowadays	RB
cord-270892-ycc3csyh	756	33	chemoinformatics	chemoinformatics	NNP
cord-270892-ycc3csyh	756	34	plays	play	VBZ
cord-270892-ycc3csyh	756	35	a	a	DT
cord-270892-ycc3csyh	756	36	predominant	predominant	JJ
cord-270892-ycc3csyh	756	37	role	role	NN
cord-270892-ycc3csyh	756	38	in	in	IN
cord-270892-ycc3csyh	756	39	drug	drug	NN
cord-270892-ycc3csyh	756	40	research	research	NN
cord-270892-ycc3csyh	756	41	.	.	.
cord-270892-ycc3csyh	757	1	335	335	CD
cord-270892-ycc3csyh	758	1	The	the	DT
cord-270892-ycc3csyh	758	2	key	key	JJ
cord-270892-ycc3csyh	758	3	goal	goal	NN
cord-270892-ycc3csyh	758	4	of	of	IN
cord-270892-ycc3csyh	758	5	the	the	DT
cord-270892-ycc3csyh	758	6	use	use	NN
cord-270892-ycc3csyh	758	7	of	of	IN
cord-270892-ycc3csyh	758	8	such	such	JJ
cord-270892-ycc3csyh	758	9	methods	method	NNS
cord-270892-ycc3csyh	758	10	is	be	VBZ
cord-270892-ycc3csyh	758	11	to	to	TO
cord-270892-ycc3csyh	758	12	reduce	reduce	VB
cord-270892-ycc3csyh	758	13	the	the	DT
cord-270892-ycc3csyh	758	14	overall	overall	JJ
cord-270892-ycc3csyh	758	15	cost	cost	NN
cord-270892-ycc3csyh	758	16	associated	associate	VBN
cord-270892-ycc3csyh	758	17	to	to	IN
cord-270892-ycc3csyh	758	18	the	the	DT
cord-270892-ycc3csyh	758	19	discovery	discovery	NN
cord-270892-ycc3csyh	758	20	and	and	CC
cord-270892-ycc3csyh	758	21	development	development	NN
cord-270892-ycc3csyh	758	22	of	of	IN
cord-270892-ycc3csyh	758	23	a	a	DT
cord-270892-ycc3csyh	758	24	new	new	JJ
cord-270892-ycc3csyh	758	25	drug	drug	NN
cord-270892-ycc3csyh	758	26	by	by	IN
cord-270892-ycc3csyh	758	27	identifying	identify	VBG
cord-270892-ycc3csyh	758	28	the	the	DT
cord-270892-ycc3csyh	758	29	most	most	RBS
cord-270892-ycc3csyh	758	30	promising	promising	JJ
cord-270892-ycc3csyh	758	31	candidates	candidate	NNS
cord-270892-ycc3csyh	758	32	to	to	TO
cord-270892-ycc3csyh	758	33	focus	focus	VB
cord-270892-ycc3csyh	758	34	the	the	DT
cord-270892-ycc3csyh	758	35	experimental	experimental	JJ
cord-270892-ycc3csyh	758	36	efforts	effort	NNS
cord-270892-ycc3csyh	758	37	on	on	IN
cord-270892-ycc3csyh	758	38	.	.	.
cord-270892-ycc3csyh	759	1	A	a	DT
cord-270892-ycc3csyh	759	2	number	number	NN
cord-270892-ycc3csyh	759	3	of	of	IN
cord-270892-ycc3csyh	759	4	books	book	NNS
cord-270892-ycc3csyh	759	5	and	and	CC
cord-270892-ycc3csyh	759	6	reviews	review	NNS
cord-270892-ycc3csyh	759	7	on	on	IN
cord-270892-ycc3csyh	759	8	the	the	DT
cord-270892-ycc3csyh	759	9	impact	impact	NN
cord-270892-ycc3csyh	759	10	of	of	IN
cord-270892-ycc3csyh	759	11	computational	computational	JJ
cord-270892-ycc3csyh	759	12	chemistry	chemistry	NN
cord-270892-ycc3csyh	759	13	for	for	IN
cord-270892-ycc3csyh	759	14	lead	lead	JJ
cord-270892-ycc3csyh	759	15	structure	structure	NN
cord-270892-ycc3csyh	759	16	determination	determination	NN
cord-270892-ycc3csyh	759	17	highlight	highlight	VBP
cord-270892-ycc3csyh	759	18	these	these	DT
cord-270892-ycc3csyh	759	19	efforts	effort	NNS
cord-270892-ycc3csyh	759	20	.	.	.
cord-270892-ycc3csyh	760	1	[	[	-LRB-
cord-270892-ycc3csyh	760	2	336	336	CD
cord-270892-ycc3csyh	760	3	]	]	-RRB-
cord-270892-ycc3csyh	760	4	[	[	-LRB-
cord-270892-ycc3csyh	760	5	337	337	CD
cord-270892-ycc3csyh	760	6	]	]	-RRB-
cord-270892-ycc3csyh	760	7	[	[	-LRB-
cord-270892-ycc3csyh	760	8	338	338	CD
cord-270892-ycc3csyh	760	9	]	]	-RRB-
cord-270892-ycc3csyh	760	10	[	[	-LRB-
cord-270892-ycc3csyh	760	11	339	339	CD
cord-270892-ycc3csyh	760	12	]	]	-RRB-
cord-270892-ycc3csyh	761	1	In	in	IN
cord-270892-ycc3csyh	761	2	general	general	JJ
cord-270892-ycc3csyh	761	3	,	,	,
cord-270892-ycc3csyh	761	4	in	in	IN
cord-270892-ycc3csyh	761	5	silico	silico	NN
cord-270892-ycc3csyh	761	6	methods	method	NNS
cord-270892-ycc3csyh	761	7	can	can	MD
cord-270892-ycc3csyh	761	8	be	be	VB
cord-270892-ycc3csyh	761	9	divided	divide	VBN
cord-270892-ycc3csyh	761	10	into	into	IN
cord-270892-ycc3csyh	761	11	(	(	-LRB-
cord-270892-ycc3csyh	761	12	i	i	NN
cord-270892-ycc3csyh	761	13	)	)	-RRB-
cord-270892-ycc3csyh	761	14	ligand	ligand	NN
cord-270892-ycc3csyh	761	15	-	-	HYPH
cord-270892-ycc3csyh	761	16	based	base	VBN
cord-270892-ycc3csyh	761	17	approaches	approach	NNS
cord-270892-ycc3csyh	761	18	,	,	,
cord-270892-ycc3csyh	761	19	which	which	WDT
cord-270892-ycc3csyh	761	20	rely	rely	VBP
cord-270892-ycc3csyh	761	21	on	on	IN
cord-270892-ycc3csyh	761	22	known	know	VBN
cord-270892-ycc3csyh	761	23	active	active	JJ
cord-270892-ycc3csyh	761	24	compounds	compound	NNS
cord-270892-ycc3csyh	761	25	.	.	.
cord-270892-ycc3csyh	762	1	Based	base	VBN
cord-270892-ycc3csyh	762	2	on	on	IN
cord-270892-ycc3csyh	762	3	their	-PRON-	PRP$
cord-270892-ycc3csyh	762	4	physicochemical	physicochemical	JJ
cord-270892-ycc3csyh	762	5	properties	property	NNS
cord-270892-ycc3csyh	762	6	crucial	crucial	JJ
cord-270892-ycc3csyh	762	7	for	for	IN
cord-270892-ycc3csyh	762	8	biological	biological	JJ
cord-270892-ycc3csyh	762	9	affinity	affinity	NN
cord-270892-ycc3csyh	762	10	,	,	,
cord-270892-ycc3csyh	762	11	activities	activity	NNS
cord-270892-ycc3csyh	762	12	are	be	VBP
cord-270892-ycc3csyh	762	13	predicted	predict	VBN
cord-270892-ycc3csyh	762	14	by	by	IN
cord-270892-ycc3csyh	762	15	extrapolation	extrapolation	NN
cord-270892-ycc3csyh	762	16	on	on	IN
cord-270892-ycc3csyh	762	17	not	not	RB
cord-270892-ycc3csyh	762	18	-	-	HYPH
cord-270892-ycc3csyh	762	19	yet	yet	RB
cord-270892-ycc3csyh	762	20	tested	test	VBN
cord-270892-ycc3csyh	762	21	substances	substance	NNS
cord-270892-ycc3csyh	762	22	,	,	,
cord-270892-ycc3csyh	762	23	e.g.	e.g.	RB
cord-270892-ycc3csyh	762	24	machine	machine	NN
cord-270892-ycc3csyh	762	25	learning	learning	NN
cord-270892-ycc3csyh	762	26	techniques	technique	NNS
cord-270892-ycc3csyh	762	27	and	and	CC
cord-270892-ycc3csyh	762	28	classical	classical	JJ
cord-270892-ycc3csyh	762	29	quantitative	quantitative	JJ
cord-270892-ycc3csyh	762	30	structure	structure	NN
cord-270892-ycc3csyh	762	31	-	-	HYPH
cord-270892-ycc3csyh	762	32	activity	activity	NN
cord-270892-ycc3csyh	762	33	relationship	relationship	NN
cord-270892-ycc3csyh	762	34	(	(	-LRB-
cord-270892-ycc3csyh	762	35	QSAR	QSAR	NNP
cord-270892-ycc3csyh	762	36	)	)	-RRB-
cord-270892-ycc3csyh	762	37	.	.	.
cord-270892-ycc3csyh	763	1	Ligand	ligand	NN
cord-270892-ycc3csyh	763	2	-	-	HYPH
cord-270892-ycc3csyh	763	3	based	base	VBN
cord-270892-ycc3csyh	763	4	approaches	approach	NNS
cord-270892-ycc3csyh	763	5	are	be	VBP
cord-270892-ycc3csyh	763	6	invaluable	invaluable	JJ
cord-270892-ycc3csyh	763	7	tools	tool	NNS
cord-270892-ycc3csyh	763	8	in	in	IN
cord-270892-ycc3csyh	763	9	cases	case	NNS
cord-270892-ycc3csyh	763	10	where	where	WRB
cord-270892-ycc3csyh	763	11	no	no	DT
cord-270892-ycc3csyh	763	12	structural	structural	JJ
cord-270892-ycc3csyh	763	13	information	information	NN
cord-270892-ycc3csyh	763	14	about	about	IN
cord-270892-ycc3csyh	763	15	the	the	DT
cord-270892-ycc3csyh	763	16	pharmacological	pharmacological	JJ
cord-270892-ycc3csyh	763	17	targets	target	NNS
cord-270892-ycc3csyh	763	18	is	be	VBZ
cord-270892-ycc3csyh	763	19	available	available	JJ
cord-270892-ycc3csyh	763	20	.	.	.
cord-270892-ycc3csyh	764	1	(	(	-LRB-
cord-270892-ycc3csyh	764	2	ii	ii	NN
cord-270892-ycc3csyh	764	3	)	)	-RRB-
cord-270892-ycc3csyh	765	1	On	on	IN
cord-270892-ycc3csyh	765	2	the	the	DT
cord-270892-ycc3csyh	765	3	other	other	JJ
cord-270892-ycc3csyh	765	4	hand	hand	NN
cord-270892-ycc3csyh	765	5	,	,	,
cord-270892-ycc3csyh	765	6	structurebased	structurebase	VBN
cord-270892-ycc3csyh	765	7	approaches	approach	NNS
cord-270892-ycc3csyh	765	8	use	use	VBP
cord-270892-ycc3csyh	765	9	experimentally	experimentally	RB
cord-270892-ycc3csyh	765	10	determined	determine	VBN
cord-270892-ycc3csyh	765	11	3D	3d	JJ
cord-270892-ycc3csyh	765	12	structures	structure	NNS
cord-270892-ycc3csyh	765	13	of	of	IN
cord-270892-ycc3csyh	765	14	the	the	DT
cord-270892-ycc3csyh	765	15	targets	target	NNS
cord-270892-ycc3csyh	765	16	,	,	,
cord-270892-ycc3csyh	765	17	such	such	JJ
cord-270892-ycc3csyh	765	18	as	as	IN
cord-270892-ycc3csyh	765	19	molecular	molecular	JJ
cord-270892-ycc3csyh	765	20	docking	docking	NN
cord-270892-ycc3csyh	765	21	or	or	CC
cord-270892-ycc3csyh	765	22	structure	structure	NN
cord-270892-ycc3csyh	765	23	-	-	HYPH
cord-270892-ycc3csyh	765	24	based	base	VBN
cord-270892-ycc3csyh	765	25	pharmacophore	pharmacophore	NN
cord-270892-ycc3csyh	765	26	modeling	model	VBG
cord-270892-ycc3csyh	765	27	for	for	IN
cord-270892-ycc3csyh	765	28	virtual	virtual	JJ
cord-270892-ycc3csyh	765	29	screening	screening	NN
cord-270892-ycc3csyh	765	30	.	.	.
cord-270892-ycc3csyh	766	1	These	these	DT
cord-270892-ycc3csyh	766	2	methods	method	NNS
cord-270892-ycc3csyh	766	3	allow	allow	VBP
cord-270892-ycc3csyh	766	4	for	for	IN
cord-270892-ycc3csyh	766	5	gaining	gain	VBG
cord-270892-ycc3csyh	766	6	insight	insight	NN
cord-270892-ycc3csyh	766	7	into	into	IN
cord-270892-ycc3csyh	766	8	protein	protein	NN
cord-270892-ycc3csyh	766	9	-	-	HYPH
cord-270892-ycc3csyh	766	10	ligand	ligand	NN
cord-270892-ycc3csyh	766	11	interactions	interaction	NNS
cord-270892-ycc3csyh	766	12	at	at	IN
cord-270892-ycc3csyh	766	13	an	an	DT
cord-270892-ycc3csyh	766	14	experimentally	experimentally	RB
cord-270892-ycc3csyh	766	15	determined	determine	VBN
cord-270892-ycc3csyh	766	16	(	(	-LRB-
cord-270892-ycc3csyh	766	17	static	static	JJ
cord-270892-ycc3csyh	766	18	)	)	-RRB-
cord-270892-ycc3csyh	766	19	level	level	NN
cord-270892-ycc3csyh	766	20	(	(	-LRB-
cord-270892-ycc3csyh	766	21	however	however	RB
cord-270892-ycc3csyh	766	22	not	not	RB
cord-270892-ycc3csyh	766	23	considering	consider	VBG
cord-270892-ycc3csyh	766	24	flexibility	flexibility	NN
cord-270892-ycc3csyh	766	25	)	)	-RRB-
cord-270892-ycc3csyh	766	26	.	.	.
cord-270892-ycc3csyh	767	1	A	a	DT
cord-270892-ycc3csyh	767	2	unique	unique	JJ
cord-270892-ycc3csyh	767	3	platform	platform	NN
cord-270892-ycc3csyh	767	4	containing	contain	VBG
cord-270892-ycc3csyh	767	5	3D	3D	NNP
cord-270892-ycc3csyh	767	6	coordinates	coordinate	NNS
cord-270892-ycc3csyh	767	7	of	of	IN
cord-270892-ycc3csyh	767	8	experimentally	experimentally	RB
cord-270892-ycc3csyh	767	9	solved	solve	VBN
cord-270892-ycc3csyh	767	10	protein	protein	NN
cord-270892-ycc3csyh	767	11	structures	structure	NNS
cord-270892-ycc3csyh	767	12	(	(	-LRB-
cord-270892-ycc3csyh	767	13	by	by	IN
cord-270892-ycc3csyh	767	14	X	x	NN
cord-270892-ycc3csyh	767	15	-	-	NN
cord-270892-ycc3csyh	767	16	ray	ray	JJ
cord-270892-ycc3csyh	767	17	crystallography	crystallography	NN
cord-270892-ycc3csyh	767	18	or	or	CC
cord-270892-ycc3csyh	767	19	NMR	NMR	NNP
cord-270892-ycc3csyh	767	20	)	)	-RRB-
cord-270892-ycc3csyh	767	21	is	be	VBZ
cord-270892-ycc3csyh	767	22	the	the	DT
cord-270892-ycc3csyh	767	23	Protein	Protein	NNP
cord-270892-ycc3csyh	767	24	Data	Data	NNP
cord-270892-ycc3csyh	767	25	Bank	Bank	NNP
cord-270892-ycc3csyh	767	26	(	(	-LRB-
cord-270892-ycc3csyh	767	27	PDB	PDB	NNP
cord-270892-ycc3csyh	767	28	)	)	-RRB-
cord-270892-ycc3csyh	767	29	currently	currently	RB
cord-270892-ycc3csyh	767	30	comprising	comprise	VBG
cord-270892-ycc3csyh	767	31	more	more	JJR
cord-270892-ycc3csyh	767	32	than	than	IN
cord-270892-ycc3csyh	767	33	50,000	50,000	CD
cord-270892-ycc3csyh	767	34	structures	structure	NNS
cord-270892-ycc3csyh	767	35	of	of	IN
cord-270892-ycc3csyh	767	36	biomolecules	biomolecule	NNS
cord-270892-ycc3csyh	767	37	and	and	CC
cord-270892-ycc3csyh	767	38	protein	protein	NN
cord-270892-ycc3csyh	767	39	-	-	HYPH
cord-270892-ycc3csyh	767	40	ligand	ligand	NN
cord-270892-ycc3csyh	767	41	complexes	complex	NNS
cord-270892-ycc3csyh	767	42	.	.	.
cord-270892-ycc3csyh	768	1	340	340	CD
cord-270892-ycc3csyh	768	2	Additionally	additionally	RB
cord-270892-ycc3csyh	768	3	,	,	,
cord-270892-ycc3csyh	768	4	there	there	EX
cord-270892-ycc3csyh	768	5	are	be	VBP
cord-270892-ycc3csyh	768	6	several	several	JJ
cord-270892-ycc3csyh	768	7	PDB	pdb	NN
cord-270892-ycc3csyh	768	8	-	-	HYPH
cord-270892-ycc3csyh	768	9	related	relate	VBN
cord-270892-ycc3csyh	768	10	web	web	NN
cord-270892-ycc3csyh	768	11	services	service	NNS
cord-270892-ycc3csyh	768	12	and	and	CC
cord-270892-ycc3csyh	768	13	tools	tool	NNS
cord-270892-ycc3csyh	768	14	,	,	,
cord-270892-ycc3csyh	768	15	which	which	WDT
cord-270892-ycc3csyh	768	16	enable	enable	VBP
cord-270892-ycc3csyh	768	17	to	to	TO
cord-270892-ycc3csyh	768	18	use	use	VB
cord-270892-ycc3csyh	768	19	the	the	DT
cord-270892-ycc3csyh	768	20	PDB	PDB	NNP
cord-270892-ycc3csyh	768	21	-	-	HYPH
cord-270892-ycc3csyh	768	22	portal	portal	NN
cord-270892-ycc3csyh	768	23	in	in	IN
cord-270892-ycc3csyh	768	24	a	a	DT
cord-270892-ycc3csyh	768	25	rich	rich	JJ
cord-270892-ycc3csyh	768	26	diversity	diversity	NN
cord-270892-ycc3csyh	768	27	of	of	IN
cord-270892-ycc3csyh	768	28	information	information	NN
cord-270892-ycc3csyh	768	29	services	service	NNS
cord-270892-ycc3csyh	768	30	for	for	IN
cord-270892-ycc3csyh	768	31	students	student	NNS
cord-270892-ycc3csyh	768	32	and	and	CC
cord-270892-ycc3csyh	768	33	scientists	scientist	NNS
cord-270892-ycc3csyh	768	34	.	.	.
cord-270892-ycc3csyh	769	1	341	341	CD
cord-270892-ycc3csyh	769	2	Particularly	particularly	RB
cord-270892-ycc3csyh	769	3	in	in	IN
cord-270892-ycc3csyh	769	4	the	the	DT
cord-270892-ycc3csyh	769	5	early	early	JJ
cord-270892-ycc3csyh	769	6	stage	stage	NN
cord-270892-ycc3csyh	769	7	of	of	IN
cord-270892-ycc3csyh	769	8	drug	drug	NN
cord-270892-ycc3csyh	769	9	development	development	NN
cord-270892-ycc3csyh	769	10	,	,	,
cord-270892-ycc3csyh	769	11	such	such	JJ
cord-270892-ycc3csyh	769	12	as	as	IN
cord-270892-ycc3csyh	769	13	lead	lead	JJ
cord-270892-ycc3csyh	769	14	discovery	discovery	NN
cord-270892-ycc3csyh	769	15	and	and	CC
cord-270892-ycc3csyh	769	16	lead	lead	NN
cord-270892-ycc3csyh	769	17	optimization	optimization	NN
cord-270892-ycc3csyh	769	18	,	,	,
cord-270892-ycc3csyh	769	19	computational	computational	JJ
cord-270892-ycc3csyh	769	20	approaches	approach	NNS
cord-270892-ycc3csyh	769	21	allow	allow	VBP
cord-270892-ycc3csyh	769	22	for	for	IN
cord-270892-ycc3csyh	769	23	a	a	DT
cord-270892-ycc3csyh	769	24	target	target	NN
cord-270892-ycc3csyh	769	25	-	-	HYPH
cord-270892-ycc3csyh	769	26	oriented	orient	VBN
cord-270892-ycc3csyh	769	27	and	and	CC
cord-270892-ycc3csyh	769	28	rationalized	rationalize	VBN
cord-270892-ycc3csyh	769	29	proceeding	proceeding	NN
cord-270892-ycc3csyh	769	30	,	,	,
cord-270892-ycc3csyh	769	31	and	and	CC
cord-270892-ycc3csyh	769	32	thus	thus	RB
cord-270892-ycc3csyh	769	33	may	may	MD
cord-270892-ycc3csyh	769	34	substantially	substantially	RB
cord-270892-ycc3csyh	769	35	help	help	VB
cord-270892-ycc3csyh	769	36	to	to	TO
cord-270892-ycc3csyh	769	37	maximize	maximize	VB
cord-270892-ycc3csyh	769	38	the	the	DT
cord-270892-ycc3csyh	769	39	success	success	NN
cord-270892-ycc3csyh	769	40	rate	rate	NN
cord-270892-ycc3csyh	769	41	.	.	.
cord-270892-ycc3csyh	770	1	338	338	CD
cord-270892-ycc3csyh	771	1	A	a	DT
cord-270892-ycc3csyh	771	2	recently	recently	RB
cord-270892-ycc3csyh	771	3	published	publish	VBN
cord-270892-ycc3csyh	771	4	review	review	NN
cord-270892-ycc3csyh	771	5	on	on	IN
cord-270892-ycc3csyh	771	6	the	the	DT
cord-270892-ycc3csyh	771	7	impact	impact	NN
cord-270892-ycc3csyh	771	8	of	of	IN
cord-270892-ycc3csyh	771	9	computer	computer	NN
cord-270892-ycc3csyh	771	10	-	-	HYPH
cord-270892-ycc3csyh	771	11	assisted	assist	VBN
cord-270892-ycc3csyh	771	12	approaches	approach	NNS
cord-270892-ycc3csyh	771	13	in	in	IN
cord-270892-ycc3csyh	771	14	antiviral	antiviral	JJ
cord-270892-ycc3csyh	771	15	research	research	NN
cord-270892-ycc3csyh	771	16	thoroughly	thoroughly	RB
cord-270892-ycc3csyh	771	17	describes	describe	VBZ
cord-270892-ycc3csyh	771	18	underlying	underlie	VBG
cord-270892-ycc3csyh	771	19	in	in	IN
cord-270892-ycc3csyh	771	20	silico	silico	NN
cord-270892-ycc3csyh	771	21	techniques	technique	NNS
cord-270892-ycc3csyh	771	22	,	,	,
cord-270892-ycc3csyh	771	23	and	and	CC
cord-270892-ycc3csyh	771	24	highlights	highlight	VBZ
cord-270892-ycc3csyh	771	25	the	the	DT
cord-270892-ycc3csyh	771	26	benefits	benefit	NNS
cord-270892-ycc3csyh	771	27	of	of	IN
cord-270892-ycc3csyh	771	28	computational	computational	JJ
cord-270892-ycc3csyh	771	29	approaches	approach	NNS
cord-270892-ycc3csyh	771	30	for	for	IN
cord-270892-ycc3csyh	771	31	the	the	DT
cord-270892-ycc3csyh	771	32	discovery	discovery	NN
cord-270892-ycc3csyh	771	33	of	of	IN
cord-270892-ycc3csyh	771	34	antiviral	antiviral	JJ
cord-270892-ycc3csyh	771	35	lead	lead	NN
cord-270892-ycc3csyh	771	36	structures	structure	NNS
cord-270892-ycc3csyh	771	37	.	.	.
cord-270892-ycc3csyh	772	1	342	342	CD
cord-270892-ycc3csyh	773	1	In	in	IN
cord-270892-ycc3csyh	773	2	anti	anti	JJ
cord-270892-ycc3csyh	773	3	-	-	JJ
cord-270892-ycc3csyh	773	4	HRV	HRV	NNP
cord-270892-ycc3csyh	773	5	research	research	NN
cord-270892-ycc3csyh	773	6	the	the	DT
cord-270892-ycc3csyh	773	7	capsid	capsid	NN
cord-270892-ycc3csyh	773	8	protein	protein	NN
cord-270892-ycc3csyh	773	9	and	and	CC
cord-270892-ycc3csyh	773	10	the	the	DT
cord-270892-ycc3csyh	773	11	protease	protease	NN
cord-270892-ycc3csyh	773	12	3C	3c	NN
cord-270892-ycc3csyh	773	13	revealed	reveal	VBD
cord-270892-ycc3csyh	773	14	to	to	TO
cord-270892-ycc3csyh	773	15	be	be	VB
cord-270892-ycc3csyh	773	16	promising	promising	JJ
cord-270892-ycc3csyh	773	17	targets	target	NNS
cord-270892-ycc3csyh	773	18	(	(	-LRB-
cord-270892-ycc3csyh	773	19	as	as	IN
cord-270892-ycc3csyh	773	20	described	describe	VBN
cord-270892-ycc3csyh	773	21	before	before	RB
cord-270892-ycc3csyh	773	22	)	)	-RRB-
cord-270892-ycc3csyh	773	23	.	.	.
cord-270892-ycc3csyh	774	1	Inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	774	2	are	be	VBP
cord-270892-ycc3csyh	774	3	assumed	assume	VBN
cord-270892-ycc3csyh	774	4	to	to	TO
cord-270892-ycc3csyh	774	5	have	have	VB
cord-270892-ycc3csyh	774	6	a	a	DT
cord-270892-ycc3csyh	774	7	major	major	JJ
cord-270892-ycc3csyh	774	8	impact	impact	NN
cord-270892-ycc3csyh	774	9	for	for	IN
cord-270892-ycc3csyh	774	10	the	the	DT
cord-270892-ycc3csyh	774	11	treatment	treatment	NN
cord-270892-ycc3csyh	774	12	of	of	IN
cord-270892-ycc3csyh	774	13	HRV	HRV	NNP
cord-270892-ycc3csyh	774	14	-	-	HYPH
cord-270892-ycc3csyh	774	15	infections	infection	NNS
cord-270892-ycc3csyh	774	16	.	.	.
cord-270892-ycc3csyh	775	1	Additionally	additionally	RB
cord-270892-ycc3csyh	775	2	,	,	,
cord-270892-ycc3csyh	775	3	these	these	DT
cord-270892-ycc3csyh	775	4	targets	target	NNS
cord-270892-ycc3csyh	775	5	are	be	VBP
cord-270892-ycc3csyh	775	6	structurally	structurally	RB
cord-270892-ycc3csyh	775	7	elucidated	elucidate	VBN
cord-270892-ycc3csyh	775	8	,	,	,
cord-270892-ycc3csyh	775	9	and	and	CC
cord-270892-ycc3csyh	775	10	some	some	DT
cord-270892-ycc3csyh	775	11	potent	potent	JJ
cord-270892-ycc3csyh	775	12	ligands	ligand	NNS
cord-270892-ycc3csyh	775	13	are	be	VBP
cord-270892-ycc3csyh	775	14	known	know	VBN
cord-270892-ycc3csyh	775	15	as	as	RB
cord-270892-ycc3csyh	775	16	well	well	RB
cord-270892-ycc3csyh	775	17	.	.	.
cord-270892-ycc3csyh	776	1	These	these	DT
cord-270892-ycc3csyh	776	2	facts	fact	NNS
cord-270892-ycc3csyh	776	3	enable	enable	VBP
cord-270892-ycc3csyh	776	4	the	the	DT
cord-270892-ycc3csyh	776	5	performance	performance	NN
cord-270892-ycc3csyh	776	6	of	of	IN
cord-270892-ycc3csyh	776	7	sensible	sensible	JJ
cord-270892-ycc3csyh	776	8	computer	computer	NN
cord-270892-ycc3csyh	776	9	-	-	HYPH
cord-270892-ycc3csyh	776	10	assisted	assist	VBN
cord-270892-ycc3csyh	776	11	approaches	approach	NNS
cord-270892-ycc3csyh	776	12	,	,	,
cord-270892-ycc3csyh	776	13	both	both	DT
cord-270892-ycc3csyh	776	14	ligand	ligand	NN
cord-270892-ycc3csyh	776	15	-	-	HYPH
cord-270892-ycc3csyh	776	16	and	and	CC
cord-270892-ycc3csyh	776	17	structure	structure	NN
cord-270892-ycc3csyh	776	18	-	-	HYPH
cord-270892-ycc3csyh	776	19	based	base	VBN
cord-270892-ycc3csyh	776	20	.	.	.
cord-270892-ycc3csyh	777	1	Some	some	DT
cord-270892-ycc3csyh	777	2	studies	study	NNS
cord-270892-ycc3csyh	777	3	using	use	VBG
cord-270892-ycc3csyh	777	4	an	an	DT
cord-270892-ycc3csyh	777	5	in	in	IN
cord-270892-ycc3csyh	777	6	silico	silico	NN
cord-270892-ycc3csyh	777	7	approach	approach	NN
cord-270892-ycc3csyh	777	8	for	for	IN
cord-270892-ycc3csyh	777	9	the	the	DT
cord-270892-ycc3csyh	777	10	discovery	discovery	NN
cord-270892-ycc3csyh	777	11	of	of	IN
cord-270892-ycc3csyh	777	12	potential	potential	JJ
cord-270892-ycc3csyh	777	13	anti	anti	JJ
cord-270892-ycc3csyh	777	14	-	-	JJ
cord-270892-ycc3csyh	777	15	HRV	HRV	NNP
cord-270892-ycc3csyh	777	16	agents	agent	NNS
cord-270892-ycc3csyh	777	17	focusing	focus	VBG
cord-270892-ycc3csyh	777	18	on	on	IN
cord-270892-ycc3csyh	777	19	the	the	DT
cord-270892-ycc3csyh	777	20	mentioned	mention	VBN
cord-270892-ycc3csyh	777	21	targets	target	NNS
cord-270892-ycc3csyh	777	22	will	will	MD
cord-270892-ycc3csyh	777	23	be	be	VB
cord-270892-ycc3csyh	777	24	reported	report	VBN
cord-270892-ycc3csyh	777	25	in	in	IN
cord-270892-ycc3csyh	777	26	the	the	DT
cord-270892-ycc3csyh	777	27	following	following	JJ
cord-270892-ycc3csyh	777	28	paragraphs	paragraph	NNS
cord-270892-ycc3csyh	777	29	.	.	.
cord-270892-ycc3csyh	778	1	For	for	IN
cord-270892-ycc3csyh	778	2	compounds	compound	NNS
cord-270892-ycc3csyh	778	3	acting	act	VBG
cord-270892-ycc3csyh	778	4	as	as	IN
cord-270892-ycc3csyh	778	5	potential	potential	JJ
cord-270892-ycc3csyh	778	6	HRV	HRV	NNP
cord-270892-ycc3csyh	778	7	-	-	HYPH
cord-270892-ycc3csyh	778	8	capsid	capsid	NN
cord-270892-ycc3csyh	778	9	binders	binder	NNS
cord-270892-ycc3csyh	778	10	,	,	,
cord-270892-ycc3csyh	778	11	some	some	DT
cord-270892-ycc3csyh	778	12	classical	classical	JJ
cord-270892-ycc3csyh	778	13	QSAR	QSAR	NNP
cord-270892-ycc3csyh	778	14	and	and	CC
cord-270892-ycc3csyh	778	15	3D	3D	NNP
cord-270892-ycc3csyh	778	16	QSAR	QSAR	NNP
cord-270892-ycc3csyh	778	17	studies	study	NNS
cord-270892-ycc3csyh	778	18	have	have	VBP
cord-270892-ycc3csyh	778	19	been	be	VBN
cord-270892-ycc3csyh	778	20	performed	perform	VBN
cord-270892-ycc3csyh	778	21	.	.	.
cord-270892-ycc3csyh	779	1	While	while	IN
cord-270892-ycc3csyh	779	2	in	in	IN
cord-270892-ycc3csyh	779	3	classical	classical	JJ
cord-270892-ycc3csyh	779	4	QSAR	QSAR	NNP
cord-270892-ycc3csyh	779	5	,	,	,
cord-270892-ycc3csyh	779	6	the	the	DT
cord-270892-ycc3csyh	779	7	relationship	relationship	NN
cord-270892-ycc3csyh	779	8	between	between	IN
cord-270892-ycc3csyh	779	9	2D	2D	NNP
cord-270892-ycc3csyh	779	10	calculated	calculate	VBN
cord-270892-ycc3csyh	779	11	properties	property	NNS
cord-270892-ycc3csyh	779	12	derived	derive	VBN
cord-270892-ycc3csyh	779	13	from	from	IN
cord-270892-ycc3csyh	779	14	chemical	chemical	JJ
cord-270892-ycc3csyh	779	15	structures	structure	NNS
cord-270892-ycc3csyh	779	16	and	and	CC
cord-270892-ycc3csyh	779	17	measured	measure	VBN
cord-270892-ycc3csyh	779	18	biological	biological	JJ
cord-270892-ycc3csyh	779	19	activities	activity	NNS
cord-270892-ycc3csyh	779	20	are	be	VBP
cord-270892-ycc3csyh	779	21	explored	explore	VBN
cord-270892-ycc3csyh	779	22	statistically	statistically	RB
cord-270892-ycc3csyh	779	23	,	,	,
cord-270892-ycc3csyh	779	24	3D	3d	JJ
cord-270892-ycc3csyh	779	25	QSAR	QSAR	NNP
cord-270892-ycc3csyh	779	26	techniques	technique	NNS
cord-270892-ycc3csyh	779	27	are	be	VBP
cord-270892-ycc3csyh	779	28	aimed	aim	VBN
cord-270892-ycc3csyh	779	29	at	at	IN
cord-270892-ycc3csyh	779	30	deriving	derive	VBG
cord-270892-ycc3csyh	779	31	a	a	DT
cord-270892-ycc3csyh	779	32	correlation	correlation	NN
cord-270892-ycc3csyh	779	33	and	and	CC
cord-270892-ycc3csyh	779	34	in	in	IN
cord-270892-ycc3csyh	779	35	turn	turn	NN
cord-270892-ycc3csyh	779	36	activity	activity	NN
cord-270892-ycc3csyh	779	37	prediction	prediction	NN
cord-270892-ycc3csyh	779	38	based	base	VBN
cord-270892-ycc3csyh	779	39	on	on	IN
cord-270892-ycc3csyh	779	40	spatial	spatial	JJ
cord-270892-ycc3csyh	779	41	arrangements	arrangement	NNS
cord-270892-ycc3csyh	779	42	of	of	IN
cord-270892-ycc3csyh	779	43	chemical	chemical	JJ
cord-270892-ycc3csyh	779	44	properties	property	NNS
cord-270892-ycc3csyh	779	45	and	and	CC
cord-270892-ycc3csyh	779	46	atoms	atom	NNS
cord-270892-ycc3csyh	779	47	.	.	.
cord-270892-ycc3csyh	780	1	Applying	apply	VBG
cord-270892-ycc3csyh	780	2	the	the	DT
cord-270892-ycc3csyh	780	3	3D	3d	JJ
cord-270892-ycc3csyh	780	4	QSAR	QSAR	NNP
cord-270892-ycc3csyh	780	5	technique	technique	NN
cord-270892-ycc3csyh	781	1	CoMFA	comfa	NN
cord-270892-ycc3csyh	782	1	(	(	-LRB-
cord-270892-ycc3csyh	782	2	Comparative	Comparative	NNP
cord-270892-ycc3csyh	782	3	Molecular	Molecular	NNP
cord-270892-ycc3csyh	782	4	Field	Field	NNP
cord-270892-ycc3csyh	782	5	Analysis	Analysis	NNP
cord-270892-ycc3csyh	782	6	)	)	-RRB-
cord-270892-ycc3csyh	783	1	statistical	statistical	JJ
cord-270892-ycc3csyh	783	2	models	model	NNS
cord-270892-ycc3csyh	783	3	are	be	VBP
cord-270892-ycc3csyh	783	4	derived	derive	VBN
cord-270892-ycc3csyh	783	5	,	,	,
cord-270892-ycc3csyh	783	6	which	which	WDT
cord-270892-ycc3csyh	783	7	are	be	VBP
cord-270892-ycc3csyh	783	8	visualized	visualize	VBN
cord-270892-ycc3csyh	783	9	in	in	IN
cord-270892-ycc3csyh	783	10	color	color	NN
cord-270892-ycc3csyh	783	11	-	-	HYPH
cord-270892-ycc3csyh	783	12	coded	code	VBN
cord-270892-ycc3csyh	783	13	contours	contour	NNS
cord-270892-ycc3csyh	783	14	around	around	IN
cord-270892-ycc3csyh	783	15	the	the	DT
cord-270892-ycc3csyh	783	16	molecule	molecule	NN
cord-270892-ycc3csyh	783	17	.	.	.
cord-270892-ycc3csyh	784	1	Therein	therein	IN
cord-270892-ycc3csyh	784	2	spots	spot	NNS
cord-270892-ycc3csyh	784	3	indicate	indicate	VBP
cord-270892-ycc3csyh	784	4	where	where	WRB
cord-270892-ycc3csyh	784	5	electrostatic	electrostatic	JJ
cord-270892-ycc3csyh	784	6	properties	property	NNS
cord-270892-ycc3csyh	784	7	and	and	CC
cord-270892-ycc3csyh	784	8	spatial	spatial	JJ
cord-270892-ycc3csyh	784	9	arrangements	arrangement	NNS
cord-270892-ycc3csyh	784	10	are	be	VBP
cord-270892-ycc3csyh	784	11	favorable	favorable	JJ
cord-270892-ycc3csyh	784	12	for	for	IN
cord-270892-ycc3csyh	784	13	biological	biological	JJ
cord-270892-ycc3csyh	784	14	activity	activity	NN
cord-270892-ycc3csyh	784	15	.	.	.
cord-270892-ycc3csyh	785	1	343	343	CD
cord-270892-ycc3csyh	786	1	In	in	IN
cord-270892-ycc3csyh	786	2	the	the	DT
cord-270892-ycc3csyh	786	3	studies	study	NNS
cord-270892-ycc3csyh	786	4	of	of	IN
cord-270892-ycc3csyh	786	5	Diana	Diana	NNP
cord-270892-ycc3csyh	786	6	et	et	NNP
cord-270892-ycc3csyh	786	7	al	al	NNP
cord-270892-ycc3csyh	786	8	.	.	NNP
cord-270892-ycc3csyh	786	9	,	,	,
cord-270892-ycc3csyh	786	10	Artico	Artico	NNP
cord-270892-ycc3csyh	786	11	et	et	NNP
cord-270892-ycc3csyh	786	12	al	al	NNP
cord-270892-ycc3csyh	786	13	.	.	NNP
cord-270892-ycc3csyh	786	14	,	,	,
cord-270892-ycc3csyh	786	15	and	and	CC
cord-270892-ycc3csyh	786	16	Verma	Verma	NNP
cord-270892-ycc3csyh	786	17	et	et	NNP
cord-270892-ycc3csyh	786	18	al	al	NNP
cord-270892-ycc3csyh	786	19	.	.	.
cord-270892-ycc3csyh	787	1	,	,	,
cord-270892-ycc3csyh	787	2	QSAR	QSAR	NNP
cord-270892-ycc3csyh	787	3	techniques	technique	NNS
cord-270892-ycc3csyh	787	4	helped	help	VBD
cord-270892-ycc3csyh	787	5	on	on	IN
cord-270892-ycc3csyh	787	6	one	one	CD
cord-270892-ycc3csyh	787	7	hand	hand	NN
cord-270892-ycc3csyh	787	8	to	to	TO
cord-270892-ycc3csyh	787	9	analyze	analyze	VB
cord-270892-ycc3csyh	787	10	and	and	CC
cord-270892-ycc3csyh	787	11	rationalize	rationalize	VB
cord-270892-ycc3csyh	787	12	the	the	DT
cord-270892-ycc3csyh	787	13	structural	structural	JJ
cord-270892-ycc3csyh	787	14	features	feature	NNS
cord-270892-ycc3csyh	787	15	of	of	IN
cord-270892-ycc3csyh	787	16	active	active	JJ
cord-270892-ycc3csyh	787	17	compounds	compound	NNS
cord-270892-ycc3csyh	787	18	essential	essential	JJ
cord-270892-ycc3csyh	787	19	for	for	IN
cord-270892-ycc3csyh	787	20	the	the	DT
cord-270892-ycc3csyh	787	21	interaction	interaction	NN
cord-270892-ycc3csyh	787	22	to	to	IN
cord-270892-ycc3csyh	787	23	the	the	DT
cord-270892-ycc3csyh	787	24	HRV	HRV	NNP
cord-270892-ycc3csyh	787	25	canyon	canyon	NN
cord-270892-ycc3csyh	787	26	's	's	POS
cord-270892-ycc3csyh	787	27	binding	bind	VBG
cord-270892-ycc3csyh	787	28	pocket	pocket	NN
cord-270892-ycc3csyh	787	29	,	,	,
cord-270892-ycc3csyh	787	30	and	and	CC
cord-270892-ycc3csyh	787	31	on	on	IN
cord-270892-ycc3csyh	787	32	the	the	DT
cord-270892-ycc3csyh	787	33	other	other	JJ
cord-270892-ycc3csyh	787	34	hand	hand	NN
cord-270892-ycc3csyh	787	35	to	to	TO
cord-270892-ycc3csyh	787	36	search	search	VB
cord-270892-ycc3csyh	787	37	for	for	IN
cord-270892-ycc3csyh	787	38	new	new	JJ
cord-270892-ycc3csyh	787	39	classes	class	NNS
cord-270892-ycc3csyh	787	40	of	of	IN
cord-270892-ycc3csyh	787	41	capsid	capsid	JJ
cord-270892-ycc3csyh	787	42	binders	binder	NNS
cord-270892-ycc3csyh	787	43	,	,	,
cord-270892-ycc3csyh	787	44	thus	thus	RB
cord-270892-ycc3csyh	787	45	to	to	TO
cord-270892-ycc3csyh	787	46	narrow	narrow	VB
cord-270892-ycc3csyh	787	47	the	the	DT
cord-270892-ycc3csyh	787	48	synthetic	synthetic	JJ
cord-270892-ycc3csyh	787	49	challenges	challenge	NNS
cord-270892-ycc3csyh	787	50	for	for	IN
cord-270892-ycc3csyh	787	51	specific	specific	JJ
cord-270892-ycc3csyh	787	52	anti	anti	JJ
cord-270892-ycc3csyh	787	53	-	-	JJ
cord-270892-ycc3csyh	787	54	HRV	HRV	NNP
cord-270892-ycc3csyh	787	55	agents	agent	NNS
cord-270892-ycc3csyh	787	56	,	,	,
cord-270892-ycc3csyh	787	57	respectively	respectively	RB
cord-270892-ycc3csyh	787	58	.	.	.
cord-270892-ycc3csyh	788	1	[	[	-LRB-
cord-270892-ycc3csyh	788	2	344	344	CD
cord-270892-ycc3csyh	788	3	]	]	-RRB-
cord-270892-ycc3csyh	788	4	[	[	-LRB-
cord-270892-ycc3csyh	788	5	345	345	CD
cord-270892-ycc3csyh	788	6	]	]	-RRB-
cord-270892-ycc3csyh	788	7	[	[	-LRB-
cord-270892-ycc3csyh	788	8	346	346	CD
cord-270892-ycc3csyh	788	9	]	]	-RRB-
cord-270892-ycc3csyh	788	10	[	[	-LRB-
cord-270892-ycc3csyh	788	11	347	347	CD
cord-270892-ycc3csyh	788	12	]	]	-RRB-
cord-270892-ycc3csyh	788	13	[	[	-LRB-
cord-270892-ycc3csyh	788	14	348	348	CD
cord-270892-ycc3csyh	788	15	]	]	-RRB-
cord-270892-ycc3csyh	789	1	In	in	IN
cord-270892-ycc3csyh	789	2	all	all	PDT
cord-270892-ycc3csyh	789	3	these	these	DT
cord-270892-ycc3csyh	789	4	investigations	investigation	NNS
cord-270892-ycc3csyh	789	5	hydrophobicity	hydrophobicity	NN
cord-270892-ycc3csyh	789	6	was	be	VBD
cord-270892-ycc3csyh	789	7	found	find	VBN
cord-270892-ycc3csyh	789	8	to	to	TO
cord-270892-ycc3csyh	789	9	be	be	VB
cord-270892-ycc3csyh	789	10	one	one	CD
cord-270892-ycc3csyh	789	11	of	of	IN
cord-270892-ycc3csyh	789	12	the	the	DT
cord-270892-ycc3csyh	789	13	most	most	RBS
cord-270892-ycc3csyh	789	14	important	important	JJ
cord-270892-ycc3csyh	789	15	determinants	determinant	NNS
cord-270892-ycc3csyh	789	16	of	of	IN
cord-270892-ycc3csyh	789	17	substance	substance	NN
cord-270892-ycc3csyh	789	18	activity	activity	NN
cord-270892-ycc3csyh	789	19	.	.	.
cord-270892-ycc3csyh	790	1	QSAR	QSAR	NNP
cord-270892-ycc3csyh	790	2	combined	combine	VBN
cord-270892-ycc3csyh	790	3	with	with	IN
cord-270892-ycc3csyh	790	4	simplex	simplex	JJ
cord-270892-ycc3csyh	790	5	representation	representation	NN
cord-270892-ycc3csyh	790	6	of	of	IN
cord-270892-ycc3csyh	790	7	molecular	molecular	JJ
cord-270892-ycc3csyh	790	8	structure	structure	NN
cord-270892-ycc3csyh	790	9	was	be	VBD
cord-270892-ycc3csyh	790	10	applied	apply	VBN
cord-270892-ycc3csyh	790	11	by	by	IN
cord-270892-ycc3csyh	790	12	Kuz'min	Kuz'min	NNP
cord-270892-ycc3csyh	790	13	et	et	NNP
cord-270892-ycc3csyh	790	14	al	al	NNP
cord-270892-ycc3csyh	790	15	.	.	.
cord-270892-ycc3csyh	791	1	based	base	VBN
cord-270892-ycc3csyh	791	2	on	on	IN
cord-270892-ycc3csyh	791	3	the	the	DT
cord-270892-ycc3csyh	791	4	selectivity	selectivity	NN
cord-270892-ycc3csyh	791	5	index	index	NN
cord-270892-ycc3csyh	791	6	(	(	-LRB-
cord-270892-ycc3csyh	791	7	CC	CC	NNP
cord-270892-ycc3csyh	791	8	50	50	CD
cord-270892-ycc3csyh	791	9	/IC	/IC	NFP
cord-270892-ycc3csyh	791	10	50	50	CD
cord-270892-ycc3csyh	791	11	)	)	-RRB-
cord-270892-ycc3csyh	791	12	and	and	CC
cord-270892-ycc3csyh	791	13	the	the	DT
cord-270892-ycc3csyh	791	14	HRV-2	HRV-2	NNP
cord-270892-ycc3csyh	791	15	inhibitory	inhibitory	JJ
cord-270892-ycc3csyh	791	16	concentration	concentration	NN
cord-270892-ycc3csyh	791	17	of	of	IN
cord-270892-ycc3csyh	791	18	a	a	DT
cord-270892-ycc3csyh	791	19	set	set	NN
cord-270892-ycc3csyh	791	20	of	of	IN
cord-270892-ycc3csyh	791	21	[	[	-LRB-
cord-270892-ycc3csyh	791	22	(	(	-LRB-
cord-270892-ycc3csyh	791	23	biphenyloxy)propyl]isoxazole	biphenyloxy)propyl]isoxazole	NNP
cord-270892-ycc3csyh	791	24	derivatives	derivative	NNS
cord-270892-ycc3csyh	791	25	.	.	.
cord-270892-ycc3csyh	792	1	188	188	CD
cord-270892-ycc3csyh	793	1	On	on	IN
cord-270892-ycc3csyh	793	2	the	the	DT
cord-270892-ycc3csyh	793	3	basis	basis	NN
cord-270892-ycc3csyh	793	4	of	of	IN
cord-270892-ycc3csyh	793	5	QSAR	QSAR	NNP
cord-270892-ycc3csyh	793	6	analysis	analysis	NN
cord-270892-ycc3csyh	793	7	and	and	CC
cord-270892-ycc3csyh	793	8	computational	computational	JJ
cord-270892-ycc3csyh	793	9	design	design	NN
cord-270892-ycc3csyh	793	10	,	,	,
cord-270892-ycc3csyh	793	11	three	three	CD
cord-270892-ycc3csyh	793	12	new	new	JJ
cord-270892-ycc3csyh	793	13	isoxazoles	isoxazole	NNS
cord-270892-ycc3csyh	793	14	with	with	IN
cord-270892-ycc3csyh	793	15	high	high	JJ
cord-270892-ycc3csyh	793	16	activity	activity	NN
cord-270892-ycc3csyh	793	17	prediction	prediction	NN
cord-270892-ycc3csyh	793	18	were	be	VBD
cord-270892-ycc3csyh	793	19	selected	select	VBN
cord-270892-ycc3csyh	793	20	and	and	CC
cord-270892-ycc3csyh	793	21	synthesized	synthesize	VBN
cord-270892-ycc3csyh	793	22	.	.	.
cord-270892-ycc3csyh	794	1	They	-PRON-	PRP
cord-270892-ycc3csyh	794	2	all	all	DT
cord-270892-ycc3csyh	794	3	revealed	reveal	VBD
cord-270892-ycc3csyh	794	4	a	a	DT
cord-270892-ycc3csyh	794	5	strong	strong	JJ
cord-270892-ycc3csyh	794	6	coincidence	coincidence	NN
cord-270892-ycc3csyh	794	7	between	between	IN
cord-270892-ycc3csyh	794	8	experimental	experimental	JJ
cord-270892-ycc3csyh	794	9	and	and	CC
cord-270892-ycc3csyh	794	10	predicted	predict	VBD
cord-270892-ycc3csyh	794	11	anti	anti	JJ
cord-270892-ycc3csyh	794	12	-	-	JJ
cord-270892-ycc3csyh	794	13	HRV	HRV	NNP
cord-270892-ycc3csyh	794	14	activity	activity	NN
cord-270892-ycc3csyh	794	15	and	and	CC
cord-270892-ycc3csyh	794	16	selectivity	selectivity	NN
cord-270892-ycc3csyh	794	17	index	index	NN
cord-270892-ycc3csyh	794	18	.	.	.
cord-270892-ycc3csyh	795	1	Terminal	terminal	JJ
cord-270892-ycc3csyh	795	2	benzene	benzene	NN
cord-270892-ycc3csyh	795	3	substituents	substituent	NNS
cord-270892-ycc3csyh	795	4	with	with	IN
cord-270892-ycc3csyh	795	5	negative	negative	JJ
cord-270892-ycc3csyh	795	6	electrostatic	electrostatic	JJ
cord-270892-ycc3csyh	795	7	potential	potential	NN
cord-270892-ycc3csyh	795	8	and	and	CC
cord-270892-ycc3csyh	795	9	a	a	DT
cord-270892-ycc3csyh	795	10	molecule	molecule	NN
cord-270892-ycc3csyh	795	11	length	length	NN
cord-270892-ycc3csyh	795	12	of	of	IN
cord-270892-ycc3csyh	795	13	approximately	approximately	RB
cord-270892-ycc3csyh	795	14	5.5	5.5	CD
cord-270892-ycc3csyh	795	15	-	-	SYM
cord-270892-ycc3csyh	795	16	5.6	5.6	CD
cord-270892-ycc3csyh	795	17	Å	å	NN
cord-270892-ycc3csyh	795	18	have	have	VBP
cord-270892-ycc3csyh	795	19	been	be	VBN
cord-270892-ycc3csyh	795	20	suggested	suggest	VBN
cord-270892-ycc3csyh	795	21	as	as	IN
cord-270892-ycc3csyh	795	22	mandatory	mandatory	JJ
cord-270892-ycc3csyh	795	23	features	feature	NNS
cord-270892-ycc3csyh	795	24	within	within	IN
cord-270892-ycc3csyh	795	25	this	this	DT
cord-270892-ycc3csyh	795	26	chemical	chemical	JJ
cord-270892-ycc3csyh	795	27	class	class	NN
cord-270892-ycc3csyh	795	28	for	for	IN
cord-270892-ycc3csyh	795	29	a	a	DT
cord-270892-ycc3csyh	795	30	HRV-2	HRV-2	NNP
cord-270892-ycc3csyh	795	31	inhibitory	inhibitory	JJ
cord-270892-ycc3csyh	795	32	activity	activity	NN
cord-270892-ycc3csyh	795	33	.	.	.
cord-270892-ycc3csyh	796	1	HRV	HRV	NNP
cord-270892-ycc3csyh	796	2	-	-	HYPH
cord-270892-ycc3csyh	796	3	serotypes	serotype	NNS
cord-270892-ycc3csyh	796	4	show	show	VBP
cord-270892-ycc3csyh	796	5	a	a	DT
cord-270892-ycc3csyh	796	6	high	high	JJ
cord-270892-ycc3csyh	796	7	level	level	NN
cord-270892-ycc3csyh	796	8	of	of	IN
cord-270892-ycc3csyh	796	9	conservation	conservation	NN
cord-270892-ycc3csyh	796	10	at	at	IN
cord-270892-ycc3csyh	796	11	the	the	DT
cord-270892-ycc3csyh	796	12	protease	protease	NN
cord-270892-ycc3csyh	796	13	3C	3c	NN
cord-270892-ycc3csyh	796	14	binding	bind	VBG
cord-270892-ycc3csyh	796	15	site	site	NN
cord-270892-ycc3csyh	796	16	;	;	:
cord-270892-ycc3csyh	796	17	Sequence	sequence	NN
cord-270892-ycc3csyh	796	18	alignment	alignment	NN
cord-270892-ycc3csyh	796	19	and	and	CC
cord-270892-ycc3csyh	796	20	secondary	secondary	JJ
cord-270892-ycc3csyh	796	21	structure	structure	NN
cord-270892-ycc3csyh	796	22	predictions	prediction	NNS
cord-270892-ycc3csyh	796	23	suggested	suggest	VBD
cord-270892-ycc3csyh	796	24	an	an	DT
cord-270892-ycc3csyh	796	25	overall	overall	JJ
cord-270892-ycc3csyh	796	26	architecture	architecture	NN
cord-270892-ycc3csyh	796	27	and	and	CC
cord-270892-ycc3csyh	796	28	mechanism	mechanism	NN
cord-270892-ycc3csyh	796	29	of	of	IN
cord-270892-ycc3csyh	796	30	HRV-3C	HRV-3C	NNP
cord-270892-ycc3csyh	796	31	proteases	protease	NNS
cord-270892-ycc3csyh	796	32	that	that	WDT
cord-270892-ycc3csyh	796	33	correlates	correlate	VBZ
cord-270892-ycc3csyh	796	34	with	with	IN
cord-270892-ycc3csyh	796	35	cellular	cellular	JJ
cord-270892-ycc3csyh	796	36	cystein	cystein	JJ
cord-270892-ycc3csyh	796	37	-	-	HYPH
cord-270892-ycc3csyh	796	38	and	and	CC
cord-270892-ycc3csyh	796	39	serine	serine	NN
cord-270892-ycc3csyh	796	40	proteases	protease	NNS
cord-270892-ycc3csyh	796	41	,	,	,
cord-270892-ycc3csyh	796	42	such	such	JJ
cord-270892-ycc3csyh	796	43	as	as	IN
cord-270892-ycc3csyh	796	44	chymotrypsin	chymotrypsin	NNP
cord-270892-ycc3csyh	796	45	and	and	CC
cord-270892-ycc3csyh	796	46	trypsin	trypsin	NN
cord-270892-ycc3csyh	796	47	.	.	.
cord-270892-ycc3csyh	797	1	349	349	CD
cord-270892-ycc3csyh	797	2	,	,	,
cord-270892-ycc3csyh	797	3	350	350	CD
cord-270892-ycc3csyh	797	4	The	the	DT
cord-270892-ycc3csyh	797	5	identity	identity	NN
cord-270892-ycc3csyh	797	6	among	among	IN
cord-270892-ycc3csyh	797	7	3C	3c	NN
cord-270892-ycc3csyh	797	8	proteases	protease	NNS
cord-270892-ycc3csyh	797	9	from	from	IN
cord-270892-ycc3csyh	797	10	different	different	JJ
cord-270892-ycc3csyh	797	11	families	family	NNS
cord-270892-ycc3csyh	797	12	is	be	VBZ
cord-270892-ycc3csyh	797	13	however	however	RB
cord-270892-ycc3csyh	797	14	modest	modest	JJ
cord-270892-ycc3csyh	797	15	and	and	CC
cord-270892-ycc3csyh	797	16	provides	provide	VBZ
cord-270892-ycc3csyh	797	17	space	space	NN
cord-270892-ycc3csyh	797	18	for	for	IN
cord-270892-ycc3csyh	797	19	the	the	DT
cord-270892-ycc3csyh	797	20	development	development	NN
cord-270892-ycc3csyh	797	21	of	of	IN
cord-270892-ycc3csyh	797	22	specific	specific	JJ
cord-270892-ycc3csyh	797	23	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	797	24	for	for	IN
cord-270892-ycc3csyh	797	25	HRV-3C	HRV-3C	NNP
cord-270892-ycc3csyh	797	26	protease	protease	NN
cord-270892-ycc3csyh	797	27	.	.	.
cord-270892-ycc3csyh	798	1	350	350	CD
cord-270892-ycc3csyh	799	1	In	in	IN
cord-270892-ycc3csyh	799	2	a	a	DT
cord-270892-ycc3csyh	799	3	recently	recently	RB
cord-270892-ycc3csyh	799	4	published	publish	VBN
cord-270892-ycc3csyh	799	5	review	review	NN
cord-270892-ycc3csyh	799	6	on	on	IN
cord-270892-ycc3csyh	799	7	selective	selective	JJ
cord-270892-ycc3csyh	799	8	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	799	9	of	of	IN
cord-270892-ycc3csyh	799	10	picornavirus	picornavirus	NNP
cord-270892-ycc3csyh	799	11	replication	replication	NN
cord-270892-ycc3csyh	799	12	,	,	,
cord-270892-ycc3csyh	799	13	De	De	NNP
cord-270892-ycc3csyh	799	14	Palma	Palma	NNP
cord-270892-ycc3csyh	799	15	et	et	NNP
cord-270892-ycc3csyh	799	16	al	al	NNP
cord-270892-ycc3csyh	799	17	.	.	NNP
cord-270892-ycc3csyh	799	18	summarized	summarize	VBD
cord-270892-ycc3csyh	799	19	all	all	DT
cord-270892-ycc3csyh	799	20	currently	currently	RB
cord-270892-ycc3csyh	799	21	known	know	VBN
cord-270892-ycc3csyh	799	22	chemical	chemical	NN
cord-270892-ycc3csyh	799	23	structures	structure	NNS
cord-270892-ycc3csyh	799	24	acting	act	VBG
cord-270892-ycc3csyh	799	25	as	as	IN
cord-270892-ycc3csyh	799	26	peptidic	peptidic	NNP
cord-270892-ycc3csyh	799	27	or	or	CC
cord-270892-ycc3csyh	799	28	nonpeptidic	nonpeptidic	NNP
cord-270892-ycc3csyh	799	29	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	799	30	of	of	IN
cord-270892-ycc3csyh	799	31	this	this	DT
cord-270892-ycc3csyh	799	32	viral	viral	JJ
cord-270892-ycc3csyh	799	33	target	target	NN
cord-270892-ycc3csyh	799	34	.	.	.
cord-270892-ycc3csyh	800	1	156	156	CD
cord-270892-ycc3csyh	801	1	In	in	IN
cord-270892-ycc3csyh	801	2	2000	2000	CD
cord-270892-ycc3csyh	801	3	,	,	,
cord-270892-ycc3csyh	801	4	Reich	Reich	NNP
cord-270892-ycc3csyh	801	5	et	et	NNP
cord-270892-ycc3csyh	801	6	al	al	NNP
cord-270892-ycc3csyh	801	7	.	.	NNP
cord-270892-ycc3csyh	801	8	,	,	,
cord-270892-ycc3csyh	801	9	used	use	VBD
cord-270892-ycc3csyh	801	10	the	the	DT
cord-270892-ycc3csyh	801	11	HRV	HRV	NNP
cord-270892-ycc3csyh	801	12	3C	3C	NNP
cord-270892-ycc3csyh	801	13	protease	protease	NN
cord-270892-ycc3csyh	801	14	co	co	NN
cord-270892-ycc3csyh	801	15	-	-	JJ
cord-270892-ycc3csyh	801	16	crystal	crystal	JJ
cord-270892-ycc3csyh	801	17	structure	structure	NN
cord-270892-ycc3csyh	801	18	information	information	NN
cord-270892-ycc3csyh	801	19	to	to	TO
cord-270892-ycc3csyh	801	20	rationalize	rationalize	VB
cord-270892-ycc3csyh	801	21	the	the	DT
cord-270892-ycc3csyh	801	22	target	target	NN
cord-270892-ycc3csyh	801	23	-	-	HYPH
cord-270892-ycc3csyh	801	24	oriented	orient	VBN
cord-270892-ycc3csyh	801	25	synthesis	synthesis	NN
cord-270892-ycc3csyh	801	26	of	of	IN
cord-270892-ycc3csyh	801	27	HRV	HRV	NNP
cord-270892-ycc3csyh	801	28	3C	3C	NNP
cord-270892-ycc3csyh	801	29	protease	protease	NN
cord-270892-ycc3csyh	801	30	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	801	31	from	from	IN
cord-270892-ycc3csyh	801	32	the	the	DT
cord-270892-ycc3csyh	801	33	class	class	NN
cord-270892-ycc3csyh	801	34	of	of	IN
cord-270892-ycc3csyh	801	35	substituted	substitute	VBN
cord-270892-ycc3csyh	801	36	benzamides	benzamide	NNS
cord-270892-ycc3csyh	801	37	.	.	.
cord-270892-ycc3csyh	802	1	Activity	activity	NN
cord-270892-ycc3csyh	802	2	data	datum	NNS
cord-270892-ycc3csyh	802	3	and	and	CC
cord-270892-ycc3csyh	802	4	subsequent	subsequent	JJ
cord-270892-ycc3csyh	802	5	crystallographic	crystallographic	JJ
cord-270892-ycc3csyh	802	6	studies	study	NNS
cord-270892-ycc3csyh	802	7	pointed	point	VBD
cord-270892-ycc3csyh	802	8	out	out	RP
cord-270892-ycc3csyh	802	9	important	important	JJ
cord-270892-ycc3csyh	802	10	requirements	requirement	NNS
cord-270892-ycc3csyh	802	11	for	for	IN
cord-270892-ycc3csyh	802	12	the	the	DT
cord-270892-ycc3csyh	802	13	inhibition	inhibition	NN
cord-270892-ycc3csyh	802	14	of	of	IN
cord-270892-ycc3csyh	802	15	the	the	DT
cord-270892-ycc3csyh	802	16	3C	3C	NNP
cord-270892-ycc3csyh	802	17	protease	protease	NN
cord-270892-ycc3csyh	802	18	.	.	.
cord-270892-ycc3csyh	803	1	351	351	CD
cord-270892-ycc3csyh	804	1	Similarly	similarly	RB
cord-270892-ycc3csyh	804	2	,	,	,
cord-270892-ycc3csyh	804	3	Maugeri	Maugeri	NNP
cord-270892-ycc3csyh	804	4	et	et	NNP
cord-270892-ycc3csyh	804	5	al	al	NNP
cord-270892-ycc3csyh	804	6	.	.	NNP
cord-270892-ycc3csyh	804	7	used	use	VBD
cord-270892-ycc3csyh	804	8	a	a	DT
cord-270892-ycc3csyh	804	9	structure	structure	NN
cord-270892-ycc3csyh	804	10	-	-	HYPH
cord-270892-ycc3csyh	804	11	based	base	VBN
cord-270892-ycc3csyh	804	12	approach	approach	NN
cord-270892-ycc3csyh	804	13	,	,	,
cord-270892-ycc3csyh	804	14	and	and	CC
cord-270892-ycc3csyh	804	15	performed	perform	VBD
cord-270892-ycc3csyh	804	16	docking	docking	NN
cord-270892-ycc3csyh	804	17	studies	study	NNS
cord-270892-ycc3csyh	804	18	based	base	VBN
cord-270892-ycc3csyh	804	19	on	on	IN
cord-270892-ycc3csyh	804	20	the	the	DT
cord-270892-ycc3csyh	804	21	3C	3C	NNP
cord-270892-ycc3csyh	804	22	protease	protease	NNP
cord-270892-ycc3csyh	804	23	crystal	crystal	NNP
cord-270892-ycc3csyh	804	24	structure	structure	NN
cord-270892-ycc3csyh	804	25	with	with	IN
cord-270892-ycc3csyh	804	26	a	a	DT
cord-270892-ycc3csyh	804	27	virtual	virtual	JJ
cord-270892-ycc3csyh	804	28	library	library	NN
cord-270892-ycc3csyh	804	29	consisting	consisting	NN
cord-270892-ycc3csyh	804	30	of	of	IN
cord-270892-ycc3csyh	804	31	benzamide	benzamide	NNP
cord-270892-ycc3csyh	804	32	derivatives	derivative	NNS
cord-270892-ycc3csyh	804	33	.	.	.
cord-270892-ycc3csyh	805	1	Quantum	quantum	NN
cord-270892-ycc3csyh	805	2	-	-	HYPH
cord-270892-ycc3csyh	805	3	mechanic	mechanic	NN
cord-270892-ycc3csyh	805	4	calculation	calculation	NN
cord-270892-ycc3csyh	805	5	proposed	propose	VBD
cord-270892-ycc3csyh	805	6	substituents	substituent	NNS
cord-270892-ycc3csyh	805	7	with	with	IN
cord-270892-ycc3csyh	805	8	most	most	RBS
cord-270892-ycc3csyh	805	9	promising	promising	JJ
cord-270892-ycc3csyh	805	10	biological	biological	JJ
cord-270892-ycc3csyh	805	11	activities	activity	NNS
cord-270892-ycc3csyh	805	12	.	.	.
cord-270892-ycc3csyh	806	1	This	this	DT
cord-270892-ycc3csyh	806	2	workflow	workflow	NN
cord-270892-ycc3csyh	806	3	guided	guide	VBD
cord-270892-ycc3csyh	806	4	the	the	DT
cord-270892-ycc3csyh	806	5	design	design	NN
cord-270892-ycc3csyh	806	6	and	and	CC
cord-270892-ycc3csyh	806	7	synthesis	synthesis	NN
cord-270892-ycc3csyh	806	8	of	of	IN
cord-270892-ycc3csyh	806	9	substances	substance	NNS
cord-270892-ycc3csyh	806	10	virtually	virtually	RB
cord-270892-ycc3csyh	806	11	assumed	assume	VBN
cord-270892-ycc3csyh	806	12	to	to	TO
cord-270892-ycc3csyh	806	13	act	act	VB
cord-270892-ycc3csyh	806	14	as	as	IN
cord-270892-ycc3csyh	806	15	substrate	substrate	JJ
cord-270892-ycc3csyh	806	16	analogues	analogue	NNS
cord-270892-ycc3csyh	806	17	.	.	.
cord-270892-ycc3csyh	807	1	Synthesis	synthesis	NN
cord-270892-ycc3csyh	807	2	of	of	IN
cord-270892-ycc3csyh	807	3	some	some	DT
cord-270892-ycc3csyh	807	4	of	of	IN
cord-270892-ycc3csyh	807	5	these	these	DT
cord-270892-ycc3csyh	807	6	compounds	compound	NNS
cord-270892-ycc3csyh	807	7	and	and	CC
cord-270892-ycc3csyh	807	8	biological	biological	JJ
cord-270892-ycc3csyh	807	9	testing	testing	NN
cord-270892-ycc3csyh	807	10	confirmed	confirm	VBD
cord-270892-ycc3csyh	807	11	the	the	DT
cord-270892-ycc3csyh	807	12	underlying	underlie	VBG
cord-270892-ycc3csyh	807	13	hypothesis	hypothesis	NN
cord-270892-ycc3csyh	807	14	.	.	.
cord-270892-ycc3csyh	808	1	219	219	CD
cord-270892-ycc3csyh	809	1	Quantitative	quantitative	JJ
cord-270892-ycc3csyh	809	2	molecular	molecular	JJ
cord-270892-ycc3csyh	809	3	modeling	modeling	NN
cord-270892-ycc3csyh	809	4	studies	study	NNS
cord-270892-ycc3csyh	809	5	were	be	VBD
cord-270892-ycc3csyh	809	6	performed	perform	VBN
cord-270892-ycc3csyh	809	7	to	to	TO
cord-270892-ycc3csyh	809	8	better	well	RBR
cord-270892-ycc3csyh	809	9	define	define	VB
cord-270892-ycc3csyh	809	10	and	and	CC
cord-270892-ycc3csyh	809	11	predict	predict	VB
cord-270892-ycc3csyh	809	12	interactions	interaction	NNS
cord-270892-ycc3csyh	809	13	between	between	IN
cord-270892-ycc3csyh	809	14	bicyclic	bicyclic	JJ
cord-270892-ycc3csyh	809	15	2-pyridone	2-pyridone	CD
cord-270892-ycc3csyh	809	16	derivatives	derivative	NNS
cord-270892-ycc3csyh	809	17	that	that	WDT
cord-270892-ycc3csyh	809	18	showed	show	VBD
cord-270892-ycc3csyh	809	19	to	to	TO
cord-270892-ycc3csyh	809	20	be	be	VB
cord-270892-ycc3csyh	809	21	irreversible	irreversible	JJ
cord-270892-ycc3csyh	809	22	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	809	23	of	of	IN
cord-270892-ycc3csyh	809	24	the	the	DT
cord-270892-ycc3csyh	809	25	3C	3C	NNP
cord-270892-ycc3csyh	809	26	protease	protease	NN
cord-270892-ycc3csyh	809	27	.	.	.
cord-270892-ycc3csyh	810	1	In	in	IN
cord-270892-ycc3csyh	810	2	these	these	DT
cord-270892-ycc3csyh	810	3	studies	study	NNS
cord-270892-ycc3csyh	810	4	molecular	molecular	JJ
cord-270892-ycc3csyh	810	5	mechanics	mechanic	NNS
cord-270892-ycc3csyh	810	6	simulations	simulation	NNS
cord-270892-ycc3csyh	810	7	to	to	TO
cord-270892-ycc3csyh	810	8	evaluate	evaluate	VB
cord-270892-ycc3csyh	810	9	chemical	chemical	JJ
cord-270892-ycc3csyh	810	10	rate	rate	NN
cord-270892-ycc3csyh	810	11	of	of	IN
cord-270892-ycc3csyh	810	12	covalent	covalent	JJ
cord-270892-ycc3csyh	810	13	bond	bond	NN
cord-270892-ycc3csyh	810	14	formation	formation	NN
cord-270892-ycc3csyh	810	15	and	and	CC
cord-270892-ycc3csyh	810	16	free	free	JJ
cord-270892-ycc3csyh	810	17	energy	energy	NN
cord-270892-ycc3csyh	810	18	calculation	calculation	NN
cord-270892-ycc3csyh	810	19	combined	combine	VBN
cord-270892-ycc3csyh	810	20	with	with	IN
cord-270892-ycc3csyh	810	21	crystallographic	crystallographic	JJ
cord-270892-ycc3csyh	810	22	studies	study	NNS
cord-270892-ycc3csyh	810	23	were	be	VBD
cord-270892-ycc3csyh	810	24	applied	apply	VBN
cord-270892-ycc3csyh	810	25	to	to	TO
cord-270892-ycc3csyh	810	26	explain	explain	VB
cord-270892-ycc3csyh	810	27	the	the	DT
cord-270892-ycc3csyh	810	28	differences	difference	NNS
cord-270892-ycc3csyh	810	29	in	in	IN
cord-270892-ycc3csyh	810	30	activity	activity	NN
cord-270892-ycc3csyh	810	31	of	of	IN
cord-270892-ycc3csyh	810	32	some	some	DT
cord-270892-ycc3csyh	810	33	irreversible	irreversible	JJ
cord-270892-ycc3csyh	810	34	peptidomimetic	peptidomimetic	JJ
cord-270892-ycc3csyh	810	35	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	810	36	.	.	.
cord-270892-ycc3csyh	811	1	These	these	DT
cord-270892-ycc3csyh	811	2	data	datum	NNS
cord-270892-ycc3csyh	811	3	were	be	VBD
cord-270892-ycc3csyh	811	4	used	use	VBN
cord-270892-ycc3csyh	811	5	as	as	IN
cord-270892-ycc3csyh	811	6	a	a	DT
cord-270892-ycc3csyh	811	7	basis	basis	NN
cord-270892-ycc3csyh	811	8	for	for	IN
cord-270892-ycc3csyh	811	9	further	further	JJ
cord-270892-ycc3csyh	811	10	optimization	optimization	NN
cord-270892-ycc3csyh	811	11	of	of	IN
cord-270892-ycc3csyh	811	12	these	these	DT
cord-270892-ycc3csyh	811	13	compounds	compound	NNS
cord-270892-ycc3csyh	811	14	.	.	.
cord-270892-ycc3csyh	812	1	224	224	CD
cord-270892-ycc3csyh	812	2	,	,	,
cord-270892-ycc3csyh	812	3	352	352	CD
cord-270892-ycc3csyh	812	4	In	in	IN
cord-270892-ycc3csyh	812	5	a	a	DT
cord-270892-ycc3csyh	812	6	recent	recent	JJ
cord-270892-ycc3csyh	812	7	study	study	NN
cord-270892-ycc3csyh	812	8	performed	perform	VBN
cord-270892-ycc3csyh	812	9	by	by	IN
cord-270892-ycc3csyh	812	10	Kuo	Kuo	NNP
cord-270892-ycc3csyh	812	11	et	et	NNP
cord-270892-ycc3csyh	812	12	al	al	NNP
cord-270892-ycc3csyh	812	13	.	.	.
cord-270892-ycc3csyh	813	1	some	some	DT
cord-270892-ycc3csyh	813	2	6,800	6,800	CD
cord-270892-ycc3csyh	813	3	compounds	compound	NNS
cord-270892-ycc3csyh	813	4	were	be	VBD
cord-270892-ycc3csyh	813	5	subjected	subject	VBN
cord-270892-ycc3csyh	813	6	to	to	IN
cord-270892-ycc3csyh	813	7	a	a	DT
cord-270892-ycc3csyh	813	8	high	high	JJ
cord-270892-ycc3csyh	813	9	troughput	troughput	NN
cord-270892-ycc3csyh	813	10	screening	screening	NN
cord-270892-ycc3csyh	813	11	in	in	IN
cord-270892-ycc3csyh	813	12	the	the	DT
cord-270892-ycc3csyh	813	13	search	search	NN
cord-270892-ycc3csyh	813	14	for	for	IN
cord-270892-ycc3csyh	813	15	novel	novel	NN
cord-270892-ycc3csyh	813	16	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	813	17	for	for	IN
cord-270892-ycc3csyh	813	18	both	both	DT
cord-270892-ycc3csyh	813	19	3C	3c	NN
cord-270892-ycc3csyh	813	20	and	and	CC
cord-270892-ycc3csyh	813	21	3CL	3CL	NNP
cord-270892-ycc3csyh	813	22	proteases	protease	NNS
cord-270892-ycc3csyh	813	23	from	from	IN
cord-270892-ycc3csyh	813	24	picornavirus	picornavirus	NN
cord-270892-ycc3csyh	813	25	and	and	CC
cord-270892-ycc3csyh	813	26	coronavirus	coronavirus	NN
cord-270892-ycc3csyh	813	27	,	,	,
cord-270892-ycc3csyh	813	28	respectively	respectively	RB
cord-270892-ycc3csyh	813	29	.	.	.
cord-270892-ycc3csyh	814	1	217	217	CD
cord-270892-ycc3csyh	814	2	Five	five	CD
cord-270892-ycc3csyh	814	3	nonpeptides	nonpeptide	NNS
cord-270892-ycc3csyh	814	4	were	be	VBD
cord-270892-ycc3csyh	814	5	identified	identify	VBN
cord-270892-ycc3csyh	814	6	with	with	IN
cord-270892-ycc3csyh	814	7	IC	IC	NNP
cord-270892-ycc3csyh	814	8	50	50	CD
cord-270892-ycc3csyh	814	9	values	value	NNS
cord-270892-ycc3csyh	814	10	r10	r10	NNP
cord-270892-ycc3csyh	814	11	mM	mm	NN
cord-270892-ycc3csyh	814	12	against	against	IN
cord-270892-ycc3csyh	814	13	severe	severe	JJ
cord-270892-ycc3csyh	814	14	acute	acute	JJ
cord-270892-ycc3csyh	814	15	respiratory	respiratory	JJ
cord-270892-ycc3csyh	814	16	syndrome	syndrome	NN
cord-270892-ycc3csyh	814	17	-	-	HYPH
cord-270892-ycc3csyh	814	18	coronavirus	coronavirus	NN
cord-270892-ycc3csyh	814	19	3CL	3cl	CD
cord-270892-ycc3csyh	814	20	-	-	HYPH
cord-270892-ycc3csyh	814	21	protease	protease	NN
cord-270892-ycc3csyh	814	22	;	;	:
cord-270892-ycc3csyh	814	23	one	one	CD
cord-270892-ycc3csyh	814	24	molecule	molecule	NN
cord-270892-ycc3csyh	814	25	was	be	VBD
cord-270892-ycc3csyh	814	26	found	find	VBN
cord-270892-ycc3csyh	814	27	to	to	TO
cord-270892-ycc3csyh	814	28	additionally	additionally	RB
cord-270892-ycc3csyh	814	29	inhibit	inhibit	VB
cord-270892-ycc3csyh	814	30	the	the	DT
cord-270892-ycc3csyh	814	31	3C	3c	NN
cord-270892-ycc3csyh	814	32	proteases	protease	NNS
cord-270892-ycc3csyh	814	33	of	of	IN
cord-270892-ycc3csyh	814	34	coxsackievirus	coxsackievirus	NNP
cord-270892-ycc3csyh	814	35	,	,	,
cord-270892-ycc3csyh	814	36	enterovirus	enterovirus	NN
cord-270892-ycc3csyh	814	37	,	,	,
cord-270892-ycc3csyh	814	38	and	and	CC
cord-270892-ycc3csyh	814	39	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	814	40	.	.	.
cord-270892-ycc3csyh	815	1	This	this	DT
cord-270892-ycc3csyh	815	2	compound	compound	NN
cord-270892-ycc3csyh	815	3	(	(	-LRB-
cord-270892-ycc3csyh	815	4	ID	ID	NNP
cord-270892-ycc3csyh	815	5	43146	43146	CD
cord-270892-ycc3csyh	815	6	)	)	-RRB-
cord-270892-ycc3csyh	815	7	contains	contain	VBZ
cord-270892-ycc3csyh	815	8	a	a	DT
cord-270892-ycc3csyh	815	9	dihydropyrazole	dihydropyrazole	NN
cord-270892-ycc3csyh	815	10	ring	ring	NN
cord-270892-ycc3csyh	815	11	decorated	decorate	VBN
cord-270892-ycc3csyh	815	12	with	with	IN
cord-270892-ycc3csyh	815	13	two	two	CD
cord-270892-ycc3csyh	815	14	phenyl	phenyl	NNP
cord-270892-ycc3csyh	815	15	groups	group	NNS
cord-270892-ycc3csyh	815	16	and	and	CC
cord-270892-ycc3csyh	815	17	a	a	DT
cord-270892-ycc3csyh	815	18	lengthy	lengthy	JJ
cord-270892-ycc3csyh	815	19	N	n	CD
cord-270892-ycc3csyh	815	20	-	-	HYPH
cord-270892-ycc3csyh	815	21	butyl	butyl	NN
cord-270892-ycc3csyh	815	22	-	-	HYPH
cord-270892-ycc3csyh	815	23	benzimidazolylamino	benzimidazolylamino	NN
cord-270892-ycc3csyh	815	24	-	-	HYPH
cord-270892-ycc3csyh	815	25	toluene	toluene	NN
cord-270892-ycc3csyh	815	26	.	.	.
cord-270892-ycc3csyh	816	1	It	-PRON-	PRP
cord-270892-ycc3csyh	816	2	was	be	VBD
cord-270892-ycc3csyh	816	3	used	use	VBN
cord-270892-ycc3csyh	816	4	as	as	IN
cord-270892-ycc3csyh	816	5	starting	start	VBG
cord-270892-ycc3csyh	816	6	point	point	NN
cord-270892-ycc3csyh	816	7	for	for	IN
cord-270892-ycc3csyh	816	8	the	the	DT
cord-270892-ycc3csyh	816	9	selection	selection	NN
cord-270892-ycc3csyh	816	10	of	of	IN
cord-270892-ycc3csyh	816	11	further	further	JJ
cord-270892-ycc3csyh	816	12	four	four	CD
cord-270892-ycc3csyh	816	13	analogs	analog	NNS
cord-270892-ycc3csyh	816	14	showing	show	VBG
cord-270892-ycc3csyh	816	15	IC	IC	NNP
cord-270892-ycc3csyh	816	16	50	50	CD
cord-270892-ycc3csyh	816	17	values	value	NNS
cord-270892-ycc3csyh	816	18	in	in	IN
cord-270892-ycc3csyh	816	19	the	the	DT
cord-270892-ycc3csyh	816	20	range	range	NN
cord-270892-ycc3csyh	816	21	of	of	IN
cord-270892-ycc3csyh	816	22	0.5	0.5	CD
cord-270892-ycc3csyh	816	23	-	-	SYM
cord-270892-ycc3csyh	816	24	10	10	CD
cord-270892-ycc3csyh	816	25	mM	mm	NN
cord-270892-ycc3csyh	816	26	against	against	IN
cord-270892-ycc3csyh	816	27	the	the	DT
cord-270892-ycc3csyh	816	28	tested	test	VBN
cord-270892-ycc3csyh	816	29	viral	viral	JJ
cord-270892-ycc3csyh	816	30	proteases	protease	NNS
cord-270892-ycc3csyh	816	31	.	.	.
cord-270892-ycc3csyh	817	1	By	by	IN
cord-270892-ycc3csyh	817	2	means	mean	NNS
cord-270892-ycc3csyh	817	3	of	of	IN
cord-270892-ycc3csyh	817	4	docking	docking	NN
cord-270892-ycc3csyh	817	5	-	-	HYPH
cord-270892-ycc3csyh	817	6	based	base	VBN
cord-270892-ycc3csyh	817	7	computer	computer	NN
cord-270892-ycc3csyh	817	8	modeling	modeling	NN
cord-270892-ycc3csyh	817	9	,	,	,
cord-270892-ycc3csyh	817	10	the	the	DT
cord-270892-ycc3csyh	817	11	authors	author	NNS
cord-270892-ycc3csyh	817	12	tried	try	VBD
cord-270892-ycc3csyh	817	13	to	to	TO
cord-270892-ycc3csyh	817	14	rationalize	rationalize	VB
cord-270892-ycc3csyh	817	15	the	the	DT
cord-270892-ycc3csyh	817	16	binding	bind	VBG
cord-270892-ycc3csyh	817	17	discrepancies	discrepancy	NNS
cord-270892-ycc3csyh	817	18	responsible	responsible	JJ
cord-270892-ycc3csyh	817	19	for	for	IN
cord-270892-ycc3csyh	817	20	individual	individual	JJ
cord-270892-ycc3csyh	817	21	and	and	CC
cord-270892-ycc3csyh	817	22	common	common	JJ
cord-270892-ycc3csyh	817	23	protease	protease	NN
cord-270892-ycc3csyh	817	24	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	817	25	,	,	,
cord-270892-ycc3csyh	817	26	thus	thus	RB
cord-270892-ycc3csyh	817	27	to	to	TO
cord-270892-ycc3csyh	817	28	provide	provide	VB
cord-270892-ycc3csyh	817	29	a	a	DT
cord-270892-ycc3csyh	817	30	rational	rational	JJ
cord-270892-ycc3csyh	817	31	base	base	NN
cord-270892-ycc3csyh	817	32	for	for	IN
cord-270892-ycc3csyh	817	33	the	the	DT
cord-270892-ycc3csyh	817	34	development	development	NN
cord-270892-ycc3csyh	817	35	of	of	IN
cord-270892-ycc3csyh	817	36	nonpeptide	nonpeptide	JJ
cord-270892-ycc3csyh	817	37	multiple	multiple	JJ
cord-270892-ycc3csyh	817	38	-	-	HYPH
cord-270892-ycc3csyh	817	39	function	function	NN
cord-270892-ycc3csyh	817	40	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	817	41	against	against	IN
cord-270892-ycc3csyh	817	42	coronaviruses	coronaviruse	NNS
cord-270892-ycc3csyh	817	43	and	and	CC
cord-270892-ycc3csyh	817	44	piciornaviruses	piciornaviruse	NNS
cord-270892-ycc3csyh	817	45	.	.	.
cord-270892-ycc3csyh	818	1	In	in	IN
cord-270892-ycc3csyh	818	2	anti	anti	JJ
cord-270892-ycc3csyh	818	3	-	-	JJ
cord-270892-ycc3csyh	818	4	HRV	HRV	NNP
cord-270892-ycc3csyh	818	5	research	research	NN
cord-270892-ycc3csyh	818	6	,	,	,
cord-270892-ycc3csyh	818	7	first	first	JJ
cord-270892-ycc3csyh	818	8	application	application	NN
cord-270892-ycc3csyh	818	9	scenarios	scenario	NNS
cord-270892-ycc3csyh	818	10	have	have	VBP
cord-270892-ycc3csyh	818	11	been	be	VBN
cord-270892-ycc3csyh	818	12	conducted	conduct	VBN
cord-270892-ycc3csyh	818	13	using	use	VBG
cord-270892-ycc3csyh	818	14	pharmacophore	pharmacophore	NN
cord-270892-ycc3csyh	818	15	models	model	NNS
cord-270892-ycc3csyh	818	16	.	.	.
cord-270892-ycc3csyh	819	1	According	accord	VBG
cord-270892-ycc3csyh	819	2	to	to	IN
cord-270892-ycc3csyh	819	3	the	the	DT
cord-270892-ycc3csyh	819	4	official	official	JJ
cord-270892-ycc3csyh	819	5	IUPAC	IUPAC	NNP
cord-270892-ycc3csyh	819	6	definition	definition	NN
cord-270892-ycc3csyh	819	7	by	by	IN
cord-270892-ycc3csyh	819	8	Wermuth	Wermuth	NNP
cord-270892-ycc3csyh	819	9	et	et	NNP
cord-270892-ycc3csyh	819	10	al	al	NNP
cord-270892-ycc3csyh	819	11	.	.	.
cord-270892-ycc3csyh	820	1	,	,	,
cord-270892-ycc3csyh	820	2	353	353	CD
cord-270892-ycc3csyh	820	3	a	a	DT
cord-270892-ycc3csyh	820	4	pharmacophore	pharmacophore	NN
cord-270892-ycc3csyh	820	5	describes	describe	VBZ
cord-270892-ycc3csyh	820	6	the	the	DT
cord-270892-ycc3csyh	820	7	3D	3d	JJ
cord-270892-ycc3csyh	820	8	arrangement	arrangement	NN
cord-270892-ycc3csyh	820	9	of	of	IN
cord-270892-ycc3csyh	820	10	steric	steric	JJ
cord-270892-ycc3csyh	820	11	and	and	CC
cord-270892-ycc3csyh	820	12	electronic	electronic	JJ
cord-270892-ycc3csyh	820	13	features	feature	NNS
cord-270892-ycc3csyh	820	14	necessary	necessary	JJ
cord-270892-ycc3csyh	820	15	to	to	TO
cord-270892-ycc3csyh	820	16	trigger	trigger	VB
cord-270892-ycc3csyh	820	17	or	or	CC
cord-270892-ycc3csyh	820	18	block	block	VB
cord-270892-ycc3csyh	820	19	a	a	DT
cord-270892-ycc3csyh	820	20	biological	biological	JJ
cord-270892-ycc3csyh	820	21	response	response	NN
cord-270892-ycc3csyh	820	22	.	.	.
cord-270892-ycc3csyh	821	1	Pharmacophores	pharmacophore	NNS
cord-270892-ycc3csyh	821	2	can	can	MD
cord-270892-ycc3csyh	821	3	be	be	VB
cord-270892-ycc3csyh	821	4	represented	represent	VBN
cord-270892-ycc3csyh	821	5	by	by	IN
cord-270892-ycc3csyh	821	6	three	three	CD
cord-270892-ycc3csyh	821	7	-	-	HYPH
cord-270892-ycc3csyh	821	8	dimensional	dimensional	JJ
cord-270892-ycc3csyh	821	9	chemical	chemical	NN
cord-270892-ycc3csyh	821	10	features	feature	NNS
cord-270892-ycc3csyh	821	11	,	,	,
cord-270892-ycc3csyh	821	12	which	which	WDT
cord-270892-ycc3csyh	821	13	include	include	VBP
cord-270892-ycc3csyh	821	14	hydrogen	hydrogen	NN
cord-270892-ycc3csyh	821	15	bond	bond	NN
cord-270892-ycc3csyh	821	16	donors	donor	NNS
cord-270892-ycc3csyh	821	17	and	and	CC
cord-270892-ycc3csyh	821	18	acceptors	acceptor	NNS
cord-270892-ycc3csyh	821	19	,	,	,
cord-270892-ycc3csyh	821	20	aromatic	aromatic	JJ
cord-270892-ycc3csyh	821	21	rings	ring	NNS
cord-270892-ycc3csyh	821	22	,	,	,
cord-270892-ycc3csyh	821	23	hydrophobic	hydrophobic	JJ
cord-270892-ycc3csyh	821	24	groups	group	NNS
cord-270892-ycc3csyh	821	25	,	,	,
cord-270892-ycc3csyh	821	26	as	as	RB
cord-270892-ycc3csyh	821	27	well	well	RB
cord-270892-ycc3csyh	821	28	as	as	IN
cord-270892-ycc3csyh	821	29	positive	positive	JJ
cord-270892-ycc3csyh	821	30	and	and	CC
cord-270892-ycc3csyh	821	31	negative	negative	JJ
cord-270892-ycc3csyh	821	32	ionisable	ionisable	JJ
cord-270892-ycc3csyh	821	33	moieties	moiety	NNS
cord-270892-ycc3csyh	821	34	.	.	.
cord-270892-ycc3csyh	822	1	Additionally	additionally	RB
cord-270892-ycc3csyh	822	2	,	,	,
cord-270892-ycc3csyh	822	3	the	the	DT
cord-270892-ycc3csyh	822	4	shape	shape	NN
cord-270892-ycc3csyh	822	5	of	of	IN
cord-270892-ycc3csyh	822	6	ligands	ligand	NNS
cord-270892-ycc3csyh	822	7	can	can	MD
cord-270892-ycc3csyh	822	8	be	be	VB
cord-270892-ycc3csyh	822	9	represented	represent	VBN
cord-270892-ycc3csyh	822	10	by	by	IN
cord-270892-ycc3csyh	822	11	shape	shape	NN
cord-270892-ycc3csyh	822	12	features	feature	NNS
cord-270892-ycc3csyh	822	13	,	,	,
cord-270892-ycc3csyh	822	14	which	which	WDT
cord-270892-ycc3csyh	822	15	essentially	essentially	RB
cord-270892-ycc3csyh	822	16	describe	describe	VBP
cord-270892-ycc3csyh	822	17	the	the	DT
cord-270892-ycc3csyh	822	18	van	van	NNP
cord-270892-ycc3csyh	822	19	der	der	NNP
cord-270892-ycc3csyh	822	20	Waals	Waals	NNP
cord-270892-ycc3csyh	822	21	radii	radii	NN
cord-270892-ycc3csyh	822	22	of	of	IN
cord-270892-ycc3csyh	822	23	the	the	DT
cord-270892-ycc3csyh	822	24	ligand	ligand	NN
cord-270892-ycc3csyh	822	25	atoms	atom	NNS
cord-270892-ycc3csyh	822	26	.	.	.
cord-270892-ycc3csyh	823	1	The	the	DT
cord-270892-ycc3csyh	823	2	pharmacophore	pharmacophore	NN
cord-270892-ycc3csyh	823	3	concept	concept	NN
cord-270892-ycc3csyh	823	4	has	have	VBZ
cord-270892-ycc3csyh	823	5	proven	prove	VBN
cord-270892-ycc3csyh	823	6	to	to	TO
cord-270892-ycc3csyh	823	7	be	be	VB
cord-270892-ycc3csyh	823	8	successful	successful	JJ
cord-270892-ycc3csyh	823	9	,	,	,
cord-270892-ycc3csyh	823	10	not	not	RB
cord-270892-ycc3csyh	823	11	only	only	RB
cord-270892-ycc3csyh	823	12	in	in	IN
cord-270892-ycc3csyh	823	13	rationalizing	rationalize	VBG
cord-270892-ycc3csyh	823	14	structure	structure	NN
cord-270892-ycc3csyh	823	15	-	-	HYPH
cord-270892-ycc3csyh	823	16	activity	activity	NN
cord-270892-ycc3csyh	823	17	relationships	relationship	NNS
cord-270892-ycc3csyh	823	18	but	but	CC
cord-270892-ycc3csyh	823	19	also	also	RB
cord-270892-ycc3csyh	823	20	by	by	IN
cord-270892-ycc3csyh	823	21	its	-PRON-	PRP$
cord-270892-ycc3csyh	823	22	large	large	JJ
cord-270892-ycc3csyh	823	23	impact	impact	NN
cord-270892-ycc3csyh	823	24	in	in	IN
cord-270892-ycc3csyh	823	25	developing	develop	VBG
cord-270892-ycc3csyh	823	26	appropriate	appropriate	JJ
cord-270892-ycc3csyh	823	27	3D	3d	JJ
cord-270892-ycc3csyh	823	28	-	-	HYPH
cord-270892-ycc3csyh	823	29	tools	tool	NNS
cord-270892-ycc3csyh	823	30	for	for	IN
cord-270892-ycc3csyh	823	31	efficient	efficient	JJ
cord-270892-ycc3csyh	823	32	virtual	virtual	JJ
cord-270892-ycc3csyh	823	33	screening	screening	NN
cord-270892-ycc3csyh	823	34	.	.	.
cord-270892-ycc3csyh	824	1	336	336	CD
cord-270892-ycc3csyh	824	2	,	,	,
cord-270892-ycc3csyh	824	3	354	354	CD
cord-270892-ycc3csyh	824	4	Steindl	Steindl	NNP
cord-270892-ycc3csyh	824	5	et	et	NNP
cord-270892-ycc3csyh	824	6	al	al	NNP
cord-270892-ycc3csyh	824	7	.	.	.
cord-270892-ycc3csyh	825	1	elaborated	elaborate	VBN
cord-270892-ycc3csyh	825	2	ligand	ligand	NN
cord-270892-ycc3csyh	825	3	-	-	HYPH
cord-270892-ycc3csyh	825	4	and	and	CC
cord-270892-ycc3csyh	825	5	structure	structure	NN
cord-270892-ycc3csyh	825	6	-	-	HYPH
cord-270892-ycc3csyh	825	7	based	base	VBN
cord-270892-ycc3csyh	825	8	pharmacophore	pharmacophore	NN
cord-270892-ycc3csyh	825	9	models	model	NNS
cord-270892-ycc3csyh	825	10	implementing	implement	VBG
cord-270892-ycc3csyh	825	11	the	the	DT
cord-270892-ycc3csyh	825	12	essential	essential	JJ
cord-270892-ycc3csyh	825	13	feature	feature	NN
cord-270892-ycc3csyh	825	14	of	of	IN
cord-270892-ycc3csyh	825	15	the	the	DT
cord-270892-ycc3csyh	825	16	covalent	covalent	NN
cord-270892-ycc3csyh	825	17	binding	binding	NN
cord-270892-ycc3csyh	825	18	to	to	IN
cord-270892-ycc3csyh	825	19	the	the	DT
cord-270892-ycc3csyh	825	20	cysteine	cysteine	NN
cord-270892-ycc3csyh	825	21	147	147	CD
cord-270892-ycc3csyh	825	22	in	in	IN
cord-270892-ycc3csyh	825	23	the	the	DT
cord-270892-ycc3csyh	825	24	active	active	JJ
cord-270892-ycc3csyh	825	25	site	site	NN
cord-270892-ycc3csyh	825	26	of	of	IN
cord-270892-ycc3csyh	825	27	the	the	DT
cord-270892-ycc3csyh	825	28	HRV-2	HRV-2	NNP
cord-270892-ycc3csyh	825	29	3C	3c	NN
cord-270892-ycc3csyh	825	30	protease	protease	NN
cord-270892-ycc3csyh	825	31	.	.	.
cord-270892-ycc3csyh	826	1	Thus	thus	RB
cord-270892-ycc3csyh	826	2	,	,	,
cord-270892-ycc3csyh	826	3	the	the	DT
cord-270892-ycc3csyh	826	4	in	in	IN
cord-270892-ycc3csyh	826	5	silico	silico	NN
cord-270892-ycc3csyh	826	6	approach	approach	NN
cord-270892-ycc3csyh	826	7	focused	focus	VBD
cord-270892-ycc3csyh	826	8	on	on	IN
cord-270892-ycc3csyh	826	9	defining	define	VBG
cord-270892-ycc3csyh	826	10	a	a	DT
cord-270892-ycc3csyh	826	11	new	new	JJ
cord-270892-ycc3csyh	826	12	pharmacophore	pharmacophore	NN
cord-270892-ycc3csyh	826	13	feature	feature	NN
cord-270892-ycc3csyh	826	14	representing	represent	VBG
cord-270892-ycc3csyh	826	15	a	a	DT
cord-270892-ycc3csyh	826	16	target	target	NN
cord-270892-ycc3csyh	826	17	structure	structure	NN
cord-270892-ycc3csyh	826	18	for	for	IN
cord-270892-ycc3csyh	826	19	nucleophilic	nucleophilic	JJ
cord-270892-ycc3csyh	826	20	addition	addition	NN
cord-270892-ycc3csyh	826	21	in	in	IN
cord-270892-ycc3csyh	826	22	the	the	DT
cord-270892-ycc3csyh	826	23	ligands	ligand	NNS
cord-270892-ycc3csyh	826	24	,	,	,
cord-270892-ycc3csyh	826	25	which	which	WDT
cord-270892-ycc3csyh	826	26	is	be	VBZ
cord-270892-ycc3csyh	826	27	a	a	DT
cord-270892-ycc3csyh	826	28	crucial	crucial	JJ
cord-270892-ycc3csyh	826	29	step	step	NN
cord-270892-ycc3csyh	826	30	for	for	IN
cord-270892-ycc3csyh	826	31	protease	protease	NN
cord-270892-ycc3csyh	826	32	inactivation	inactivation	NN
cord-270892-ycc3csyh	826	33	.	.	.
cord-270892-ycc3csyh	827	1	The	the	DT
cord-270892-ycc3csyh	827	2	generated	generate	VBN
cord-270892-ycc3csyh	827	3	hypotheses	hypothesis	NNS
cord-270892-ycc3csyh	827	4	retrieved	retrieve	VBD
cord-270892-ycc3csyh	827	5	known	know	VBN
cord-270892-ycc3csyh	827	6	3C	3C	NNP
cord-270892-ycc3csyh	827	7	protease	protease	NN
cord-270892-ycc3csyh	827	8	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	827	9	in	in	IN
cord-270892-ycc3csyh	827	10	the	the	DT
cord-270892-ycc3csyh	827	11	virtual	virtual	JJ
cord-270892-ycc3csyh	827	12	screening	screening	NN
cord-270892-ycc3csyh	827	13	cycle	cycle	NN
cord-270892-ycc3csyh	827	14	,	,	,
cord-270892-ycc3csyh	827	15	and	and	CC
cord-270892-ycc3csyh	827	16	proposed	propose	VBN
cord-270892-ycc3csyh	827	17	potential	potential	NN
cord-270892-ycc3csyh	827	18	(	(	-LRB-
cord-270892-ycc3csyh	827	19	unconfirmed	unconfirmed	JJ
cord-270892-ycc3csyh	827	20	)	)	-RRB-
cord-270892-ycc3csyh	827	21	ligands	ligand	NNS
cord-270892-ycc3csyh	827	22	of	of	IN
cord-270892-ycc3csyh	827	23	the	the	DT
cord-270892-ycc3csyh	827	24	3D	3d	JJ
cord-270892-ycc3csyh	827	25	protease	protease	NN
cord-270892-ycc3csyh	827	26	binding	bind	VBG
cord-270892-ycc3csyh	827	27	site	site	NN
cord-270892-ycc3csyh	827	28	from	from	IN
cord-270892-ycc3csyh	827	29	available	available	JJ
cord-270892-ycc3csyh	827	30	databases	database	NNS
cord-270892-ycc3csyh	827	31	.	.	.
cord-270892-ycc3csyh	828	1	355	355	CD
cord-270892-ycc3csyh	829	1	The	the	DT
cord-270892-ycc3csyh	829	2	viral	viral	JJ
cord-270892-ycc3csyh	829	3	capsid	capsid	NN
cord-270892-ycc3csyh	829	4	of	of	IN
cord-270892-ycc3csyh	829	5	several	several	JJ
cord-270892-ycc3csyh	829	6	HRVs	hrv	NNS
cord-270892-ycc3csyh	829	7	has	have	VBZ
cord-270892-ycc3csyh	829	8	been	be	VBN
cord-270892-ycc3csyh	829	9	elucidated	elucidate	VBN
cord-270892-ycc3csyh	829	10	by	by	IN
cord-270892-ycc3csyh	829	11	crystallization	crystallization	NN
cord-270892-ycc3csyh	829	12	and	and	CC
cord-270892-ycc3csyh	829	13	resolution	resolution	NN
cord-270892-ycc3csyh	829	14	of	of	IN
cord-270892-ycc3csyh	829	15	the	the	DT
cord-270892-ycc3csyh	829	16	3D	3d	JJ
cord-270892-ycc3csyh	829	17	-	-	HYPH
cord-270892-ycc3csyh	829	18	structure	structure	NN
cord-270892-ycc3csyh	829	19	.	.	.
cord-270892-ycc3csyh	830	1	The	the	DT
cord-270892-ycc3csyh	830	2	HRV	HRV	NNP
cord-270892-ycc3csyh	830	3	coat	coat	NN
cord-270892-ycc3csyh	830	4	protein	protein	NN
cord-270892-ycc3csyh	830	5	complexed	complexe	VBN
cord-270892-ycc3csyh	830	6	with	with	IN
cord-270892-ycc3csyh	830	7	its	-PRON-	PRP$
cord-270892-ycc3csyh	830	8	highly	highly	RB
cord-270892-ycc3csyh	830	9	active	active	JJ
cord-270892-ycc3csyh	830	10	inhibitor	inhibitor	NN
cord-270892-ycc3csyh	830	11	WIN	WIN	NNP
cord-270892-ycc3csyh	830	12	61209	61209	CD
cord-270892-ycc3csyh	830	13	was	be	VBD
cord-270892-ycc3csyh	830	14	used	use	VBN
cord-270892-ycc3csyh	830	15	as	as	IN
cord-270892-ycc3csyh	830	16	starting	start	VBG
cord-270892-ycc3csyh	830	17	point	point	NN
cord-270892-ycc3csyh	830	18	for	for	IN
cord-270892-ycc3csyh	830	19	the	the	DT
cord-270892-ycc3csyh	830	20	generation	generation	NN
cord-270892-ycc3csyh	830	21	of	of	IN
cord-270892-ycc3csyh	830	22	structure	structure	NN
cord-270892-ycc3csyh	830	23	-	-	HYPH
cord-270892-ycc3csyh	830	24	based	base	VBN
cord-270892-ycc3csyh	830	25	pharmacophore	pharmacophore	NN
cord-270892-ycc3csyh	830	26	models	model	NNS
cord-270892-ycc3csyh	830	27	by	by	IN
cord-270892-ycc3csyh	830	28	.	.	.
cord-270892-ycc3csyh	831	1	The	the	DT
cord-270892-ycc3csyh	831	2	models	model	NNS
cord-270892-ycc3csyh	831	3	were	be	VBD
cord-270892-ycc3csyh	831	4	used	use	VBN
cord-270892-ycc3csyh	831	5	for	for	IN
cord-270892-ycc3csyh	831	6	virtual	virtual	JJ
cord-270892-ycc3csyh	831	7	screening	screening	NN
cord-270892-ycc3csyh	831	8	of	of	IN
cord-270892-ycc3csyh	831	9	a	a	DT
cord-270892-ycc3csyh	831	10	large	large	JJ
cord-270892-ycc3csyh	831	11	commercially	commercially	RB
cord-270892-ycc3csyh	831	12	available	available	JJ
cord-270892-ycc3csyh	831	13	3D	3d	JJ
cord-270892-ycc3csyh	831	14	database	database	NN
cord-270892-ycc3csyh	831	15	.	.	.
cord-270892-ycc3csyh	832	1	For	for	IN
cord-270892-ycc3csyh	832	2	final	final	JJ
cord-270892-ycc3csyh	832	3	selection	selection	NN
cord-270892-ycc3csyh	832	4	of	of	IN
cord-270892-ycc3csyh	832	5	virtual	virtual	JJ
cord-270892-ycc3csyh	832	6	hits	hit	NNS
cord-270892-ycc3csyh	832	7	worth	worth	JJ
cord-270892-ycc3csyh	832	8	to	to	TO
cord-270892-ycc3csyh	832	9	be	be	VB
cord-270892-ycc3csyh	832	10	subjected	subject	VBN
cord-270892-ycc3csyh	832	11	to	to	IN
cord-270892-ycc3csyh	832	12	biological	biological	JJ
cord-270892-ycc3csyh	832	13	testing	testing	NN
cord-270892-ycc3csyh	832	14	,	,	,
cord-270892-ycc3csyh	832	15	docking	docking	NN
cord-270892-ycc3csyh	832	16	studies	study	NNS
cord-270892-ycc3csyh	832	17	and	and	CC
cord-270892-ycc3csyh	832	18	principal	principal	JJ
cord-270892-ycc3csyh	832	19	component	component	NN
cord-270892-ycc3csyh	832	20	analysis	analysis	NN
cord-270892-ycc3csyh	832	21	were	be	VBD
cord-270892-ycc3csyh	832	22	performed	perform	VBN
cord-270892-ycc3csyh	832	23	.	.	.
cord-270892-ycc3csyh	833	1	Six	six	CD
cord-270892-ycc3csyh	833	2	candidates	candidate	NNS
cord-270892-ycc3csyh	833	3	were	be	VBD
cord-270892-ycc3csyh	833	4	tested	test	VBN
cord-270892-ycc3csyh	833	5	for	for	IN
cord-270892-ycc3csyh	833	6	their	-PRON-	PRP$
cord-270892-ycc3csyh	833	7	ability	ability	NN
cord-270892-ycc3csyh	833	8	to	to	TO
cord-270892-ycc3csyh	833	9	inhibit	inhibit	VB
cord-270892-ycc3csyh	833	10	HRV	HRV	NNP
cord-270892-ycc3csyh	833	11	serotype	serotype	NN
cord-270892-ycc3csyh	833	12	39	39	CD
cord-270892-ycc3csyh	833	13	by	by	IN
cord-270892-ycc3csyh	833	14	multiple	multiple	JJ
cord-270892-ycc3csyh	833	15	-	-	HYPH
cord-270892-ycc3csyh	833	16	cycle	cycle	NN
cord-270892-ycc3csyh	833	17	CPE	CPE	NNP
cord-270892-ycc3csyh	833	18	inhibition	inhibition	NN
cord-270892-ycc3csyh	833	19	assay	assay	NN
cord-270892-ycc3csyh	833	20	.	.	.
cord-270892-ycc3csyh	834	1	Although	although	IN
cord-270892-ycc3csyh	834	2	all	all	DT
cord-270892-ycc3csyh	834	3	of	of	IN
cord-270892-ycc3csyh	834	4	them	-PRON-	PRP
cord-270892-ycc3csyh	834	5	showed	show	VBD
cord-270892-ycc3csyh	834	6	a	a	DT
cord-270892-ycc3csyh	834	7	certain	certain	JJ
cord-270892-ycc3csyh	834	8	antiviral	antiviral	JJ
cord-270892-ycc3csyh	834	9	potential	potential	NN
cord-270892-ycc3csyh	834	10	,	,	,
cord-270892-ycc3csyh	834	11	one	one	CD
cord-270892-ycc3csyh	834	12	longitudinal	longitudinal	JJ
cord-270892-ycc3csyh	834	13	piperazine	piperazine	NN
cord-270892-ycc3csyh	834	14	derivative	derivative	NN
cord-270892-ycc3csyh	834	15	inhibited	inhibit	VBD
cord-270892-ycc3csyh	834	16	the	the	DT
cord-270892-ycc3csyh	834	17	virus	virus	NN
cord-270892-ycc3csyh	834	18	at	at	IN
cord-270892-ycc3csyh	834	19	a	a	DT
cord-270892-ycc3csyh	834	20	concentration	concentration	NN
cord-270892-ycc3csyh	834	21	below	below	IN
cord-270892-ycc3csyh	834	22	10	10	CD
cord-270892-ycc3csyh	834	23	mM.	mm.	NN
cord-270892-ycc3csyh	835	1	Some	some	DT
cord-270892-ycc3csyh	835	2	of	of	IN
cord-270892-ycc3csyh	835	3	the	the	DT
cord-270892-ycc3csyh	835	4	test	test	NN
cord-270892-ycc3csyh	835	5	candidates	candidate	NNS
cord-270892-ycc3csyh	835	6	showed	show	VBD
cord-270892-ycc3csyh	835	7	difficulties	difficulty	NNS
cord-270892-ycc3csyh	835	8	in	in	IN
cord-270892-ycc3csyh	835	9	the	the	DT
cord-270892-ycc3csyh	835	10	interpretation	interpretation	NN
cord-270892-ycc3csyh	835	11	of	of	IN
cord-270892-ycc3csyh	835	12	experimental	experimental	JJ
cord-270892-ycc3csyh	835	13	results	result	NNS
cord-270892-ycc3csyh	835	14	due	due	IN
cord-270892-ycc3csyh	835	15	to	to	IN
cord-270892-ycc3csyh	835	16	their	-PRON-	PRP$
cord-270892-ycc3csyh	835	17	relatively	relatively	RB
cord-270892-ycc3csyh	835	18	high	high	JJ
cord-270892-ycc3csyh	835	19	cytotoxicity	cytotoxicity	NN
cord-270892-ycc3csyh	835	20	and	and	CC
cord-270892-ycc3csyh	835	21	bad	bad	JJ
cord-270892-ycc3csyh	835	22	solubility	solubility	NN
cord-270892-ycc3csyh	835	23	.	.	.
cord-270892-ycc3csyh	836	1	This	this	DT
cord-270892-ycc3csyh	836	2	circumstance	circumstance	NN
cord-270892-ycc3csyh	836	3	asks	ask	VBZ
cord-270892-ycc3csyh	836	4	for	for	IN
cord-270892-ycc3csyh	836	5	more	more	RBR
cord-270892-ycc3csyh	836	6	cautious	cautious	JJ
cord-270892-ycc3csyh	836	7	estimation	estimation	NN
cord-270892-ycc3csyh	836	8	of	of	IN
cord-270892-ycc3csyh	836	9	molecular	molecular	JJ
cord-270892-ycc3csyh	836	10	properties	property	NNS
cord-270892-ycc3csyh	836	11	for	for	IN
cord-270892-ycc3csyh	836	12	compound	compound	NN
cord-270892-ycc3csyh	836	13	selection	selection	NN
cord-270892-ycc3csyh	836	14	as	as	IN
cord-270892-ycc3csyh	836	15	stated	state	VBN
cord-270892-ycc3csyh	836	16	by	by	IN
cord-270892-ycc3csyh	836	17	the	the	DT
cord-270892-ycc3csyh	836	18	authors	author	NNS
cord-270892-ycc3csyh	836	19	.	.	.
cord-270892-ycc3csyh	837	1	356	356	CD
cord-270892-ycc3csyh	838	1	In	in	IN
cord-270892-ycc3csyh	838	2	a	a	DT
cord-270892-ycc3csyh	838	3	subsequently	subsequently	RB
cord-270892-ycc3csyh	838	4	performed	perform	VBN
cord-270892-ycc3csyh	838	5	study	study	NN
cord-270892-ycc3csyh	838	6	,	,	,
cord-270892-ycc3csyh	838	7	the	the	DT
cord-270892-ycc3csyh	838	8	best	well	RBS
cord-270892-ycc3csyh	838	9	validated	validate	VBN
cord-270892-ycc3csyh	838	10	pharmacophore	pharmacophore	NN
cord-270892-ycc3csyh	838	11	model	model	NN
cord-270892-ycc3csyh	838	12	was	be	VBD
cord-270892-ycc3csyh	838	13	used	use	VBN
cord-270892-ycc3csyh	838	14	for	for	IN
cord-270892-ycc3csyh	838	15	the	the	DT
cord-270892-ycc3csyh	838	16	identification	identification	NN
cord-270892-ycc3csyh	838	17	of	of	IN
cord-270892-ycc3csyh	838	18	naturally	naturally	RB
cord-270892-ycc3csyh	838	19	derived	derive	VBN
cord-270892-ycc3csyh	838	20	HRV	HRV	NNP
cord-270892-ycc3csyh	838	21	coat	coat	NN
cord-270892-ycc3csyh	838	22	protein	protein	NN
cord-270892-ycc3csyh	838	23	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	838	24	.	.	.
cord-270892-ycc3csyh	839	1	144	144	CD
cord-270892-ycc3csyh	840	1	For	for	IN
cord-270892-ycc3csyh	840	2	virtual	virtual	JJ
cord-270892-ycc3csyh	840	3	screening	screening	NN
cord-270892-ycc3csyh	840	4	experiments	experiment	NNS
cord-270892-ycc3csyh	840	5	the	the	DT
cord-270892-ycc3csyh	840	6	in	in	IN
cord-270892-ycc3csyh	840	7	-	-	HYPH
cord-270892-ycc3csyh	840	8	house	house	NN
cord-270892-ycc3csyh	840	9	generated	generate	VBD
cord-270892-ycc3csyh	840	10	3D	3D	NNP
cord-270892-ycc3csyh	840	11	-	-	HYPH
cord-270892-ycc3csyh	840	12	database	database	NN
cord-270892-ycc3csyh	840	13	DIOS	DIOS	NNP
cord-270892-ycc3csyh	840	14	was	be	VBD
cord-270892-ycc3csyh	840	15	used	use	VBN
cord-270892-ycc3csyh	840	16	(	(	-LRB-
cord-270892-ycc3csyh	840	17	as	as	IN
cord-270892-ycc3csyh	840	18	described	describe	VBN
cord-270892-ycc3csyh	840	19	before	before	RB
cord-270892-ycc3csyh	840	20	)	)	-RRB-
cord-270892-ycc3csyh	840	21	.	.	.
cord-270892-ycc3csyh	841	1	Based	base	VBN
cord-270892-ycc3csyh	841	2	on	on	IN
cord-270892-ycc3csyh	841	3	the	the	DT
cord-270892-ycc3csyh	841	4	virtually	virtually	RB
cord-270892-ycc3csyh	841	5	predicted	predict	VBN
cord-270892-ycc3csyh	841	6	ligands	ligand	NNS
cord-270892-ycc3csyh	841	7	and	and	CC
cord-270892-ycc3csyh	841	8	considering	consider	VBG
cord-270892-ycc3csyh	841	9	knowledge	knowledge	NN
cord-270892-ycc3csyh	841	10	from	from	IN
cord-270892-ycc3csyh	841	11	traditional	traditional	JJ
cord-270892-ycc3csyh	841	12	use	use	NN
cord-270892-ycc3csyh	841	13	,	,	,
cord-270892-ycc3csyh	841	14	sesquiterpene	sesquiterpene	NN
cord-270892-ycc3csyh	841	15	umbelliferons	umbelliferon	NNS
cord-270892-ycc3csyh	841	16	from	from	IN
cord-270892-ycc3csyh	841	17	the	the	DT
cord-270892-ycc3csyh	841	18	gum	gum	NN
cord-270892-ycc3csyh	841	19	resin	resin	NN
cord-270892-ycc3csyh	841	20	of	of	IN
cord-270892-ycc3csyh	841	21	Ferula	Ferula	NNP
cord-270892-ycc3csyh	841	22	sp	sp	NN
cord-270892-ycc3csyh	841	23	.	.	NNP
cord-270892-ycc3csyh	841	24	,	,	,
cord-270892-ycc3csyh	841	25	i.e.	i.e.	FW
cord-270892-ycc3csyh	841	26	asafetida	asafetida	NNP
cord-270892-ycc3csyh	841	27	,	,	,
cord-270892-ycc3csyh	841	28	were	be	VBD
cord-270892-ycc3csyh	841	29	finally	finally	RB
cord-270892-ycc3csyh	841	30	selected	select	VBN
cord-270892-ycc3csyh	841	31	as	as	IN
cord-270892-ycc3csyh	841	32	most	most	RBS
cord-270892-ycc3csyh	841	33	promising	promising	JJ
cord-270892-ycc3csyh	841	34	candidates	candidate	NNS
cord-270892-ycc3csyh	841	35	.	.	.
cord-270892-ycc3csyh	842	1	For	for	IN
cord-270892-ycc3csyh	842	2	biological	biological	JJ
cord-270892-ycc3csyh	842	3	evaluation	evaluation	NN
cord-270892-ycc3csyh	842	4	,	,	,
cord-270892-ycc3csyh	842	5	the	the	DT
cord-270892-ycc3csyh	842	6	antiviral	antiviral	JJ
cord-270892-ycc3csyh	842	7	activities	activity	NNS
cord-270892-ycc3csyh	842	8	of	of	IN
cord-270892-ycc3csyh	842	9	asafetida	asafetida	NNP
cord-270892-ycc3csyh	842	10	and	and	CC
cord-270892-ycc3csyh	842	11	its	-PRON-	PRP$
cord-270892-ycc3csyh	842	12	isolated	isolated	JJ
cord-270892-ycc3csyh	842	13	constituents	constituent	NNS
cord-270892-ycc3csyh	842	14	were	be	VBD
cord-270892-ycc3csyh	842	15	assessed	assess	VBN
cord-270892-ycc3csyh	842	16	by	by	IN
cord-270892-ycc3csyh	842	17	an	an	DT
cord-270892-ycc3csyh	842	18	exploratory	exploratory	JJ
cord-270892-ycc3csyh	842	19	determination	determination	NN
cord-270892-ycc3csyh	842	20	of	of	IN
cord-270892-ycc3csyh	842	21	the	the	DT
cord-270892-ycc3csyh	842	22	inhibition	inhibition	NN
cord-270892-ycc3csyh	842	23	of	of	IN
cord-270892-ycc3csyh	842	24	the	the	DT
cord-270892-ycc3csyh	842	25	CPE	CPE	NNP
cord-270892-ycc3csyh	842	26	induced	induce	VBN
cord-270892-ycc3csyh	842	27	by	by	IN
cord-270892-ycc3csyh	842	28	HRV	HRV	NNP
cord-270892-ycc3csyh	842	29	serotypes	serotype	NNS
cord-270892-ycc3csyh	842	30	1A	1a	NN
cord-270892-ycc3csyh	842	31	,	,	,
cord-270892-ycc3csyh	842	32	2	2	CD
cord-270892-ycc3csyh	842	33	,	,	,
cord-270892-ycc3csyh	842	34	14	14	CD
cord-270892-ycc3csyh	842	35	,	,	,
cord-270892-ycc3csyh	842	36	and	and	CC
cord-270892-ycc3csyh	842	37	16	16	CD
cord-270892-ycc3csyh	842	38	.	.	.
cord-270892-ycc3csyh	843	1	The	the	DT
cord-270892-ycc3csyh	843	2	results	result	NNS
cord-270892-ycc3csyh	843	3	revealed	reveal	VBD
cord-270892-ycc3csyh	843	4	a	a	DT
cord-270892-ycc3csyh	843	5	dose	dose	NN
cord-270892-ycc3csyh	843	6	-	-	HYPH
cord-270892-ycc3csyh	843	7	dependent	dependent	JJ
cord-270892-ycc3csyh	843	8	and	and	CC
cord-270892-ycc3csyh	843	9	selective	selective	JJ
cord-270892-ycc3csyh	843	10	anti	anti	JJ
cord-270892-ycc3csyh	843	11	-	-	JJ
cord-270892-ycc3csyh	843	12	HRV	HRV	NNP
cord-270892-ycc3csyh	843	13	activity	activity	NN
cord-270892-ycc3csyh	843	14	against	against	IN
cord-270892-ycc3csyh	843	15	serotype	serotype	NN
cord-270892-ycc3csyh	843	16	2	2	CD
cord-270892-ycc3csyh	843	17	for	for	IN
cord-270892-ycc3csyh	843	18	asafetida	asafetida	NNP
cord-270892-ycc3csyh	843	19	and	and	CC
cord-270892-ycc3csyh	843	20	its	-PRON-	PRP$
cord-270892-ycc3csyh	843	21	virtually	virtually	RB
cord-270892-ycc3csyh	843	22	predicted	predict	VBN
cord-270892-ycc3csyh	843	23	constituents	constituent	NNS
cord-270892-ycc3csyh	843	24	,	,	,
cord-270892-ycc3csyh	843	25	farnesiferols	farnesiferols	NNP
cord-270892-ycc3csyh	843	26	B	B	NNP
cord-270892-ycc3csyh	843	27	and	and	CC
cord-270892-ycc3csyh	843	28	C	C	NNP
cord-270892-ycc3csyh	843	29	(	(	-LRB-
cord-270892-ycc3csyh	843	30	Fig	Fig	NNP
cord-270892-ycc3csyh	843	31	.	.	NNP
cord-270892-ycc3csyh	843	32	5	5	CD
cord-270892-ycc3csyh	843	33	;	;	:
cord-270892-ycc3csyh	843	34	Table	Table	NNP
cord-270892-ycc3csyh	843	35	III	III	NNP
cord-270892-ycc3csyh	843	36	;	;	:
cord-270892-ycc3csyh	843	37	IC	IC	NNP
cord-270892-ycc3csyh	843	38	50	50	CD
cord-270892-ycc3csyh	843	39	:	:	:
cord-270892-ycc3csyh	843	40	2.6	2.6	CD
cord-270892-ycc3csyh	843	41	and	and	CC
cord-270892-ycc3csyh	843	42	2.5	2.5	CD
cord-270892-ycc3csyh	843	43	mM	mm	NN
cord-270892-ycc3csyh	843	44	,	,	,
cord-270892-ycc3csyh	843	45	respectively	respectively	RB
cord-270892-ycc3csyh	843	46	)	)	-RRB-
cord-270892-ycc3csyh	843	47	.	.	.
cord-270892-ycc3csyh	844	1	To	to	TO
cord-270892-ycc3csyh	844	2	scrutinize	scrutinize	VB
cord-270892-ycc3csyh	844	3	the	the	DT
cord-270892-ycc3csyh	844	4	selectivity	selectivity	NN
cord-270892-ycc3csyh	844	5	of	of	IN
cord-270892-ycc3csyh	844	6	these	these	DT
cord-270892-ycc3csyh	844	7	two	two	CD
cord-270892-ycc3csyh	844	8	compounds	compound	NNS
cord-270892-ycc3csyh	844	9	against	against	IN
cord-270892-ycc3csyh	844	10	HRV-2	HRV-2	NNP
cord-270892-ycc3csyh	845	1	in	in	IN
cord-270892-ycc3csyh	845	2	comparison	comparison	NN
cord-270892-ycc3csyh	845	3	to	to	IN
cord-270892-ycc3csyh	845	4	the	the	DT
cord-270892-ycc3csyh	845	5	other	other	JJ
cord-270892-ycc3csyh	845	6	tested	test	VBN
cord-270892-ycc3csyh	845	7	serotypes	serotype	NNS
cord-270892-ycc3csyh	845	8	,	,	,
cord-270892-ycc3csyh	845	9	the	the	DT
cord-270892-ycc3csyh	845	10	amino	amino	NN
cord-270892-ycc3csyh	845	11	acid	acid	NN
cord-270892-ycc3csyh	845	12	sequences	sequence	NNS
cord-270892-ycc3csyh	845	13	of	of	IN
cord-270892-ycc3csyh	845	14	HRV-2	HRV-2	NNP
cord-270892-ycc3csyh	845	15	and	and	CC
cord-270892-ycc3csyh	845	16	HRV-16	HRV-16	NNP
cord-270892-ycc3csyh	846	1	VP1	VP1	NNP
cord-270892-ycc3csyh	846	2	were	be	VBD
cord-270892-ycc3csyh	846	3	aligned	align	VBN
cord-270892-ycc3csyh	846	4	.	.	.
cord-270892-ycc3csyh	847	1	Since	since	IN
cord-270892-ycc3csyh	847	2	all	all	DT
cord-270892-ycc3csyh	847	3	amino	amino	NN
cord-270892-ycc3csyh	847	4	acid	acid	NN
cord-270892-ycc3csyh	847	5	residues	residue	NNS
cord-270892-ycc3csyh	847	6	involved	involve	VBN
cord-270892-ycc3csyh	847	7	in	in	IN
cord-270892-ycc3csyh	847	8	ligand	ligand	NN
cord-270892-ycc3csyh	847	9	binding	binding	NN
cord-270892-ycc3csyh	847	10	showed	show	VBD
cord-270892-ycc3csyh	847	11	100	100	CD
cord-270892-ycc3csyh	847	12	%	%	NN
cord-270892-ycc3csyh	847	13	match	match	NN
cord-270892-ycc3csyh	847	14	in	in	IN
cord-270892-ycc3csyh	847	15	both	both	DT
cord-270892-ycc3csyh	847	16	serotypes	serotype	NNS
cord-270892-ycc3csyh	847	17	,	,	,
cord-270892-ycc3csyh	847	18	the	the	DT
cord-270892-ycc3csyh	847	19	experimentally	experimentally	RB
cord-270892-ycc3csyh	847	20	determined	determine	VBN
cord-270892-ycc3csyh	847	21	selectivity	selectivity	NN
cord-270892-ycc3csyh	847	22	profile	profile	NN
cord-270892-ycc3csyh	847	23	could	could	MD
cord-270892-ycc3csyh	847	24	not	not	RB
cord-270892-ycc3csyh	847	25	be	be	VB
cord-270892-ycc3csyh	847	26	explained	explain	VBN
cord-270892-ycc3csyh	847	27	by	by	IN
cord-270892-ycc3csyh	847	28	different	different	JJ
cord-270892-ycc3csyh	847	29	binding	bind	VBG
cord-270892-ycc3csyh	847	30	pockets	pocket	NNS
cord-270892-ycc3csyh	847	31	.	.	.
cord-270892-ycc3csyh	848	1	The	the	DT
cord-270892-ycc3csyh	848	2	serotype	serotype	NN
cord-270892-ycc3csyh	848	3	alignment	alignment	NN
cord-270892-ycc3csyh	848	4	does	do	VBZ
cord-270892-ycc3csyh	848	5	however	however	RB
cord-270892-ycc3csyh	848	6	not	not	RB
cord-270892-ycc3csyh	848	7	reflect	reflect	VB
cord-270892-ycc3csyh	848	8	potential	potential	JJ
cord-270892-ycc3csyh	848	9	protein	protein	NN
cord-270892-ycc3csyh	848	10	flexibility	flexibility	NN
cord-270892-ycc3csyh	848	11	during	during	IN
cord-270892-ycc3csyh	848	12	binding	binding	NN
cord-270892-ycc3csyh	848	13	,	,	,
cord-270892-ycc3csyh	848	14	which	which	WDT
cord-270892-ycc3csyh	848	15	might	may	MD
cord-270892-ycc3csyh	848	16	differ	differ	VB
cord-270892-ycc3csyh	848	17	between	between	IN
cord-270892-ycc3csyh	848	18	the	the	DT
cord-270892-ycc3csyh	848	19	HRV	HRV	NNP
cord-270892-ycc3csyh	848	20	serotypes	serotype	NNS
cord-270892-ycc3csyh	848	21	.	.	.
cord-270892-ycc3csyh	849	1	Additionally	additionally	RB
cord-270892-ycc3csyh	849	2	,	,	,
cord-270892-ycc3csyh	849	3	off	off	IN
cord-270892-ycc3csyh	849	4	-	-	HYPH
cord-270892-ycc3csyh	849	5	target	target	NN
cord-270892-ycc3csyh	849	6	effects	effect	NNS
cord-270892-ycc3csyh	849	7	could	could	MD
cord-270892-ycc3csyh	849	8	be	be	VB
cord-270892-ycc3csyh	849	9	a	a	DT
cord-270892-ycc3csyh	849	10	reason	reason	NN
cord-270892-ycc3csyh	849	11	for	for	IN
cord-270892-ycc3csyh	849	12	the	the	DT
cord-270892-ycc3csyh	849	13	observed	observed	JJ
cord-270892-ycc3csyh	849	14	selectivity	selectivity	NN
cord-270892-ycc3csyh	849	15	.	.	.
cord-270892-ycc3csyh	850	1	In	in	IN
cord-270892-ycc3csyh	850	2	a	a	DT
cord-270892-ycc3csyh	850	3	recently	recently	RB
cord-270892-ycc3csyh	850	4	performed	perform	VBN
cord-270892-ycc3csyh	850	5	virtual	virtual	JJ
cord-270892-ycc3csyh	850	6	parallel	parallel	JJ
cord-270892-ycc3csyh	850	7	screening	screening	NN
cord-270892-ycc3csyh	850	8	approach	approach	NN
cord-270892-ycc3csyh	850	9	,	,	,
cord-270892-ycc3csyh	850	10	we	-PRON-	PRP
cord-270892-ycc3csyh	850	11	tried	try	VBD
cord-270892-ycc3csyh	850	12	to	to	TO
cord-270892-ycc3csyh	850	13	identify	identify	VB
cord-270892-ycc3csyh	850	14	potential	potential	JJ
cord-270892-ycc3csyh	850	15	targets	target	NNS
cord-270892-ycc3csyh	850	16	of	of	IN
cord-270892-ycc3csyh	850	17	human	human	JJ
cord-270892-ycc3csyh	850	18	pathological	pathological	JJ
cord-270892-ycc3csyh	850	19	relevance	relevance	NN
cord-270892-ycc3csyh	850	20	for	for	IN
cord-270892-ycc3csyh	850	21	16	16	CD
cord-270892-ycc3csyh	850	22	constituents	constituent	NNS
cord-270892-ycc3csyh	850	23	isolated	isolate	VBN
cord-270892-ycc3csyh	850	24	and	and	CC
cord-270892-ycc3csyh	850	25	identified	identify	VBN
cord-270892-ycc3csyh	850	26	from	from	IN
cord-270892-ycc3csyh	850	27	the	the	DT
cord-270892-ycc3csyh	850	28	medicinal	medicinal	JJ
cord-270892-ycc3csyh	850	29	plant	plant	NN
cord-270892-ycc3csyh	850	30	Ruta	Ruta	NNP
cord-270892-ycc3csyh	850	31	graveolens	graveolen	NNS
cord-270892-ycc3csyh	850	32	.	.	.
cord-270892-ycc3csyh	851	1	318	318	CD
cord-270892-ycc3csyh	852	1	Using	use	VBG
cord-270892-ycc3csyh	852	2	the	the	DT
cord-270892-ycc3csyh	852	3	screening	screening	NN
cord-270892-ycc3csyh	852	4	platform	platform	NN
cord-270892-ycc3csyh	852	5	Pipline	Pipline	NNP
cord-270892-ycc3csyh	852	6	Pilot	Pilot	NNP
cord-270892-ycc3csyh	852	7	357	357	CD
cord-270892-ycc3csyh	852	8	included	include	VBD
cord-270892-ycc3csyh	852	9	in	in	IN
cord-270892-ycc3csyh	852	10	Discovery	Discovery	NNP
cord-270892-ycc3csyh	852	11	Studio	Studio	NNP
cord-270892-ycc3csyh	852	12	,	,	,
cord-270892-ycc3csyh	852	13	358	358	CD
cord-270892-ycc3csyh	852	14	low	low	JJ
cord-270892-ycc3csyh	852	15	-	-	HYPH
cord-270892-ycc3csyh	852	16	energy	energy	NN
cord-270892-ycc3csyh	852	17	conformers	conformer	NNS
cord-270892-ycc3csyh	852	18	of	of	IN
cord-270892-ycc3csyh	852	19	the	the	DT
cord-270892-ycc3csyh	852	20	16	16	CD
cord-270892-ycc3csyh	852	21	identified	identify	VBD
cord-270892-ycc3csyh	852	22	molecules	molecule	NNS
cord-270892-ycc3csyh	852	23	from	from	IN
cord-270892-ycc3csyh	852	24	R.	R.	NNP
cord-270892-ycc3csyh	852	25	graveolens	graveolen	NNS
cord-270892-ycc3csyh	852	26	were	be	VBD
cord-270892-ycc3csyh	852	27	subjected	subject	VBN
cord-270892-ycc3csyh	852	28	to	to	IN
cord-270892-ycc3csyh	852	29	parallel	parallel	JJ
cord-270892-ycc3csyh	852	30	screening	screening	NN
cord-270892-ycc3csyh	852	31	.	.	.
cord-270892-ycc3csyh	853	1	For	for	IN
cord-270892-ycc3csyh	853	2	this	this	DT
cord-270892-ycc3csyh	853	3	purpose	purpose	NN
cord-270892-ycc3csyh	853	4	,	,	,
cord-270892-ycc3csyh	853	5	the	the	DT
cord-270892-ycc3csyh	853	6	Inte	Inte	NNP
cord-270892-ycc3csyh	853	7	:	:	:
cord-270892-ycc3csyh	853	8	Ligand	Ligand	NNP
cord-270892-ycc3csyh	853	9	pharmacophore	pharmacophore	NN
cord-270892-ycc3csyh	853	10	model	model	NN
cord-270892-ycc3csyh	853	11	collection	collection	NN
cord-270892-ycc3csyh	853	12	was	be	VBD
cord-270892-ycc3csyh	853	13	used	use	VBN
cord-270892-ycc3csyh	853	14	.	.	.
cord-270892-ycc3csyh	854	1	359	359	CD
cord-270892-ycc3csyh	855	1	It	-PRON-	PRP
cord-270892-ycc3csyh	855	2	currently	currently	RB
cord-270892-ycc3csyh	855	3	comprises	comprise	VBZ
cord-270892-ycc3csyh	855	4	2.208	2.208	CD
cord-270892-ycc3csyh	855	5	models	model	NNS
cord-270892-ycc3csyh	855	6	covering	cover	VBG
cord-270892-ycc3csyh	855	7	280	280	CD
cord-270892-ycc3csyh	855	8	unique	unique	JJ
cord-270892-ycc3csyh	855	9	pharmacological	pharmacological	JJ
cord-270892-ycc3csyh	855	10	targets	target	NNS
cord-270892-ycc3csyh	855	11	.	.	.
cord-270892-ycc3csyh	856	1	Based	base	VBN
cord-270892-ycc3csyh	856	2	on	on	IN
cord-270892-ycc3csyh	856	3	the	the	DT
cord-270892-ycc3csyh	856	4	predicted	predict	VBN
cord-270892-ycc3csyh	856	5	ligand	ligand	NN
cord-270892-ycc3csyh	856	6	-	-	HYPH
cord-270892-ycc3csyh	856	7	target	target	NN
cord-270892-ycc3csyh	856	8	interactions	interaction	NNS
cord-270892-ycc3csyh	856	9	,	,	,
cord-270892-ycc3csyh	856	10	the	the	DT
cord-270892-ycc3csyh	856	11	authors	author	NNS
cord-270892-ycc3csyh	856	12	focused	focus	VBD
cord-270892-ycc3csyh	856	13	on	on	IN
cord-270892-ycc3csyh	856	14	three	three	CD
cord-270892-ycc3csyh	856	15	biological	biological	JJ
cord-270892-ycc3csyh	856	16	targets	target	NNS
cord-270892-ycc3csyh	856	17	,	,	,
cord-270892-ycc3csyh	856	18	namely	namely	RB
cord-270892-ycc3csyh	856	19	acetylcholinesterase	acetylcholinesterase	NN
cord-270892-ycc3csyh	856	20	,	,	,
cord-270892-ycc3csyh	856	21	the	the	DT
cord-270892-ycc3csyh	856	22	HRV	HRV	NNP
cord-270892-ycc3csyh	856	23	coat	coat	NN
cord-270892-ycc3csyh	856	24	protein	protein	NN
cord-270892-ycc3csyh	856	25	,	,	,
cord-270892-ycc3csyh	856	26	and	and	CC
cord-270892-ycc3csyh	856	27	the	the	DT
cord-270892-ycc3csyh	856	28	cannabinoid	cannabinoid	NN
cord-270892-ycc3csyh	856	29	receptor	receptor	NN
cord-270892-ycc3csyh	856	30	type	type	NN
cord-270892-ycc3csyh	856	31	2	2	CD
cord-270892-ycc3csyh	856	32	.	.	.
cord-270892-ycc3csyh	857	1	Virtual	virtual	JJ
cord-270892-ycc3csyh	857	2	hits	hit	NNS
cord-270892-ycc3csyh	857	3	and	and	CC
cord-270892-ycc3csyh	857	4	nonhits	nonhit	NNS
cord-270892-ycc3csyh	857	5	were	be	VBD
cord-270892-ycc3csyh	857	6	assayed	assay	VBN
cord-270892-ycc3csyh	857	7	on	on	IN
cord-270892-ycc3csyh	857	8	their	-PRON-	PRP$
cord-270892-ycc3csyh	857	9	respective	respective	JJ
cord-270892-ycc3csyh	857	10	targets	target	NNS
cord-270892-ycc3csyh	857	11	for	for	IN
cord-270892-ycc3csyh	857	12	a	a	DT
cord-270892-ycc3csyh	857	13	critical	critical	JJ
cord-270892-ycc3csyh	857	14	evaluation	evaluation	NN
cord-270892-ycc3csyh	857	15	of	of	IN
cord-270892-ycc3csyh	857	16	the	the	DT
cord-270892-ycc3csyh	857	17	performed	perform	VBN
cord-270892-ycc3csyh	857	18	target	target	NN
cord-270892-ycc3csyh	857	19	-	-	HYPH
cord-270892-ycc3csyh	857	20	fishing	fishing	NN
cord-270892-ycc3csyh	857	21	approach	approach	NN
cord-270892-ycc3csyh	857	22	.	.	.
cord-270892-ycc3csyh	858	1	Beside	beside	IN
cord-270892-ycc3csyh	858	2	other	other	JJ
cord-270892-ycc3csyh	858	3	predicted	predict	VBN
cord-270892-ycc3csyh	858	4	bioactivities	bioactivitie	NNS
cord-270892-ycc3csyh	858	5	,	,	,
cord-270892-ycc3csyh	858	6	determination	determination	NN
cord-270892-ycc3csyh	858	7	of	of	IN
cord-270892-ycc3csyh	858	8	their	-PRON-	PRP$
cord-270892-ycc3csyh	858	9	CPEs	cpe	NNS
cord-270892-ycc3csyh	858	10	on	on	IN
cord-270892-ycc3csyh	858	11	HRV-2	HRV-2	NNP
cord-270892-ycc3csyh	858	12	revealed	reveal	VBD
cord-270892-ycc3csyh	858	13	the	the	DT
cord-270892-ycc3csyh	858	14	virtual	virtual	JJ
cord-270892-ycc3csyh	858	15	hit	hit	VBN
cord-270892-ycc3csyh	858	16	arborinine	arborinine	NN
cord-270892-ycc3csyh	858	17	(	(	-LRB-
cord-270892-ycc3csyh	858	18	Fig	Fig	NNP
cord-270892-ycc3csyh	858	19	.	.	NNP
cord-270892-ycc3csyh	858	20	5	5	CD
cord-270892-ycc3csyh	858	21	;	;	:
cord-270892-ycc3csyh	858	22	Table	Table	NNP
cord-270892-ycc3csyh	858	23	III	III	NNP
cord-270892-ycc3csyh	858	24	;	;	:
cord-270892-ycc3csyh	858	25	IC	IC	NNP
cord-270892-ycc3csyh	858	26	50	50	CD
cord-270892-ycc3csyh	858	27	:	:	:
cord-270892-ycc3csyh	858	28	3.2	3.2	CD
cord-270892-ycc3csyh	858	29	mM	mm	CD
cord-270892-ycc3csyh	858	30	)	)	-RRB-
cord-270892-ycc3csyh	858	31	and	and	CC
cord-270892-ycc3csyh	858	32	the	the	DT
cord-270892-ycc3csyh	858	33	nonpredicted	nonpredicted	NNP
cord-270892-ycc3csyh	858	34	hit	hit	VBD
cord-270892-ycc3csyh	858	35	6,7,8-trimethoxycoumarin	6,7,8-trimethoxycoumarin	CD
cord-270892-ycc3csyh	859	1	(	(	-LRB-
cord-270892-ycc3csyh	859	2	Fig	Fig	NNP
cord-270892-ycc3csyh	859	3	.	.	NNP
cord-270892-ycc3csyh	859	4	5	5	CD
cord-270892-ycc3csyh	859	5	;	;	:
cord-270892-ycc3csyh	859	6	Table	Table	NNP
cord-270892-ycc3csyh	859	7	III	III	NNP
cord-270892-ycc3csyh	859	8	;	;	:
cord-270892-ycc3csyh	859	9	IC	IC	NNP
cord-270892-ycc3csyh	859	10	50	50	CD
cord-270892-ycc3csyh	859	11	:	:	:
cord-270892-ycc3csyh	859	12	12.9	12.9	CD
cord-270892-ycc3csyh	859	13	mM	mm	CD
cord-270892-ycc3csyh	859	14	)	)	-RRB-
cord-270892-ycc3csyh	859	15	as	as	IN
cord-270892-ycc3csyh	859	16	the	the	DT
cord-270892-ycc3csyh	859	17	most	most	RBS
cord-270892-ycc3csyh	859	18	active	active	JJ
cord-270892-ycc3csyh	859	19	anti	anti	JJ
cord-270892-ycc3csyh	859	20	-	-	JJ
cord-270892-ycc3csyh	859	21	HRV	HRV	NNP
cord-270892-ycc3csyh	859	22	constituents	constituent	NNS
cord-270892-ycc3csyh	859	23	.	.	.
cord-270892-ycc3csyh	860	1	It	-PRON-	PRP
cord-270892-ycc3csyh	860	2	could	could	MD
cord-270892-ycc3csyh	860	3	be	be	VB
cord-270892-ycc3csyh	860	4	shown	show	VBN
cord-270892-ycc3csyh	860	5	that	that	IN
cord-270892-ycc3csyh	860	6	the	the	DT
cord-270892-ycc3csyh	860	7	applied	apply	VBN
cord-270892-ycc3csyh	860	8	in	in	IN
cord-270892-ycc3csyh	860	9	silico	silico	NN
cord-270892-ycc3csyh	860	10	strategy	strategy	NN
cord-270892-ycc3csyh	860	11	has	have	VBZ
cord-270892-ycc3csyh	860	12	the	the	DT
cord-270892-ycc3csyh	860	13	capacity	capacity	NN
cord-270892-ycc3csyh	860	14	of	of	IN
cord-270892-ycc3csyh	860	15	catalyzing	catalyze	VBG
cord-270892-ycc3csyh	860	16	drug	drug	NN
cord-270892-ycc3csyh	860	17	discovery	discovery	NN
cord-270892-ycc3csyh	860	18	profoundly	profoundly	RB
cord-270892-ycc3csyh	860	19	for	for	IN
cord-270892-ycc3csyh	860	20	all	all	PDT
cord-270892-ycc3csyh	860	21	those	those	DT
cord-270892-ycc3csyh	860	22	diseases	disease	NNS
cord-270892-ycc3csyh	860	23	where	where	WRB
cord-270892-ycc3csyh	860	24	molecular	molecular	JJ
cord-270892-ycc3csyh	860	25	targets	target	NNS
cord-270892-ycc3csyh	860	26	or	or	CC
cord-270892-ycc3csyh	860	27	molecular	molecular	JJ
cord-270892-ycc3csyh	860	28	ligands	ligand	NNS
cord-270892-ycc3csyh	860	29	are	be	VBP
cord-270892-ycc3csyh	860	30	well	well	RB
cord-270892-ycc3csyh	860	31	defined	define	VBN
cord-270892-ycc3csyh	860	32	to	to	TO
cord-270892-ycc3csyh	860	33	create	create	VB
cord-270892-ycc3csyh	860	34	reliable	reliable	JJ
cord-270892-ycc3csyh	860	35	pharmacophore	pharmacophore	NN
cord-270892-ycc3csyh	860	36	models	model	NNS
cord-270892-ycc3csyh	860	37	.	.	.
cord-270892-ycc3csyh	861	1	HRV	HRV	NNP
cord-270892-ycc3csyh	861	2	,	,	,
cord-270892-ycc3csyh	861	3	a	a	DT
cord-270892-ycc3csyh	861	4	prominent	prominent	JJ
cord-270892-ycc3csyh	861	5	member	member	NN
cord-270892-ycc3csyh	861	6	of	of	IN
cord-270892-ycc3csyh	861	7	the	the	DT
cord-270892-ycc3csyh	861	8	Picornaviridae	Picornaviridae	NNP
cord-270892-ycc3csyh	861	9	family	family	NN
cord-270892-ycc3csyh	861	10	,	,	,
cord-270892-ycc3csyh	861	11	infects	infect	VBZ
cord-270892-ycc3csyh	861	12	humans	human	NNS
cord-270892-ycc3csyh	861	13	more	more	RBR
cord-270892-ycc3csyh	861	14	frequently	frequently	RB
cord-270892-ycc3csyh	861	15	than	than	IN
cord-270892-ycc3csyh	861	16	any	any	DT
cord-270892-ycc3csyh	861	17	other	other	JJ
cord-270892-ycc3csyh	861	18	virus	virus	NN
cord-270892-ycc3csyh	861	19	.	.	.
cord-270892-ycc3csyh	862	1	Infections	infection	NNS
cord-270892-ycc3csyh	862	2	with	with	IN
cord-270892-ycc3csyh	862	3	HRV	HRV	NNP
cord-270892-ycc3csyh	862	4	mainly	mainly	RB
cord-270892-ycc3csyh	862	5	lead	lead	VBP
cord-270892-ycc3csyh	862	6	to	to	IN
cord-270892-ycc3csyh	862	7	upper	upper	JJ
cord-270892-ycc3csyh	862	8	respiratory	respiratory	JJ
cord-270892-ycc3csyh	862	9	diseases	disease	NNS
cord-270892-ycc3csyh	862	10	,	,	,
cord-270892-ycc3csyh	862	11	such	such	JJ
cord-270892-ycc3csyh	862	12	as	as	IN
cord-270892-ycc3csyh	862	13	the	the	DT
cord-270892-ycc3csyh	862	14	common	common	JJ
cord-270892-ycc3csyh	862	15	cold	cold	NN
cord-270892-ycc3csyh	862	16	,	,	,
cord-270892-ycc3csyh	862	17	but	but	CC
cord-270892-ycc3csyh	862	18	may	may	MD
cord-270892-ycc3csyh	862	19	also	also	RB
cord-270892-ycc3csyh	862	20	cause	cause	VB
cord-270892-ycc3csyh	862	21	more	more	RBR
cord-270892-ycc3csyh	862	22	severe	severe	JJ
cord-270892-ycc3csyh	862	23	lower	low	JJR
cord-270892-ycc3csyh	862	24	respiratory	respiratory	JJ
cord-270892-ycc3csyh	862	25	tract	tract	NN
cord-270892-ycc3csyh	862	26	disorders	disorder	NNS
cord-270892-ycc3csyh	862	27	.	.	.
cord-270892-ycc3csyh	863	1	Although	although	IN
cord-270892-ycc3csyh	863	2	the	the	DT
cord-270892-ycc3csyh	863	3	symptomology	symptomology	NN
cord-270892-ycc3csyh	863	4	and	and	CC
cord-270892-ycc3csyh	863	5	severity	severity	NN
cord-270892-ycc3csyh	863	6	of	of	IN
cord-270892-ycc3csyh	863	7	the	the	DT
cord-270892-ycc3csyh	863	8	common	common	JJ
cord-270892-ycc3csyh	863	9	cold	cold	NN
cord-270892-ycc3csyh	863	10	is	be	VBZ
cord-270892-ycc3csyh	863	11	relatively	relatively	RB
cord-270892-ycc3csyh	863	12	mild	mild	JJ
cord-270892-ycc3csyh	863	13	and	and	CC
cord-270892-ycc3csyh	863	14	the	the	DT
cord-270892-ycc3csyh	863	15	course	course	NN
cord-270892-ycc3csyh	863	16	of	of	IN
cord-270892-ycc3csyh	863	17	disease	disease	NN
cord-270892-ycc3csyh	863	18	self	self	NN
cord-270892-ycc3csyh	863	19	-	-	HYPH
cord-270892-ycc3csyh	863	20	limiting	limit	VBG
cord-270892-ycc3csyh	863	21	,	,	,
cord-270892-ycc3csyh	863	22	the	the	DT
cord-270892-ycc3csyh	863	23	socio	socio	JJ
cord-270892-ycc3csyh	863	24	-	-	JJ
cord-270892-ycc3csyh	863	25	economic	economic	JJ
cord-270892-ycc3csyh	863	26	impact	impact	NN
cord-270892-ycc3csyh	863	27	is	be	VBZ
cord-270892-ycc3csyh	863	28	tremendous	tremendous	JJ
cord-270892-ycc3csyh	863	29	in	in	IN
cord-270892-ycc3csyh	863	30	terms	term	NNS
cord-270892-ycc3csyh	863	31	of	of	IN
cord-270892-ycc3csyh	863	32	recouping	recoup	VBG
cord-270892-ycc3csyh	863	33	lost	lose	VBN
cord-270892-ycc3csyh	863	34	productivity	productivity	NN
cord-270892-ycc3csyh	863	35	due	due	IN
cord-270892-ycc3csyh	863	36	to	to	IN
cord-270892-ycc3csyh	863	37	sick	sick	JJ
cord-270892-ycc3csyh	863	38	leave	leave	NN
cord-270892-ycc3csyh	863	39	.	.	.
cord-270892-ycc3csyh	864	1	In	in	IN
cord-270892-ycc3csyh	864	2	the	the	DT
cord-270892-ycc3csyh	864	3	last	last	JJ
cord-270892-ycc3csyh	864	4	decades	decade	NNS
cord-270892-ycc3csyh	864	5	,	,	,
cord-270892-ycc3csyh	864	6	a	a	DT
cord-270892-ycc3csyh	864	7	number	number	NN
cord-270892-ycc3csyh	864	8	of	of	IN
cord-270892-ycc3csyh	864	9	anti	anti	JJ
cord-270892-ycc3csyh	864	10	-	-	JJ
cord-270892-ycc3csyh	864	11	HRV	HRV	NNP
cord-270892-ycc3csyh	864	12	agents	agent	NNS
cord-270892-ycc3csyh	864	13	from	from	IN
cord-270892-ycc3csyh	864	14	different	different	JJ
cord-270892-ycc3csyh	864	15	origin	origin	NN
cord-270892-ycc3csyh	864	16	-	-	HYPH
cord-270892-ycc3csyh	864	17	synthetics	synthetic	NNS
cord-270892-ycc3csyh	864	18	,	,	,
cord-270892-ycc3csyh	864	19	natural	natural	JJ
cord-270892-ycc3csyh	864	20	compounds	compound	NNS
cord-270892-ycc3csyh	864	21	,	,	,
cord-270892-ycc3csyh	864	22	biologicals	biological	NNS
cord-270892-ycc3csyh	864	23	,	,	,
cord-270892-ycc3csyh	864	24	botanicals	botanical	NNS
cord-270892-ycc3csyh	864	25	,	,	,
cord-270892-ycc3csyh	864	26	and	and	CC
cord-270892-ycc3csyh	864	27	nutritionals	nutritional	NNS
cord-270892-ycc3csyh	864	28	-	-	,
cord-270892-ycc3csyh	864	29	have	have	VBP
cord-270892-ycc3csyh	864	30	been	be	VBN
cord-270892-ycc3csyh	864	31	discovered	discover	VBN
cord-270892-ycc3csyh	864	32	.	.	.
cord-270892-ycc3csyh	865	1	Different	different	JJ
cord-270892-ycc3csyh	865	2	concepts	concept	NNS
cord-270892-ycc3csyh	865	3	have	have	VBP
cord-270892-ycc3csyh	865	4	been	be	VBN
cord-270892-ycc3csyh	865	5	used	use	VBN
cord-270892-ycc3csyh	865	6	as	as	IN
cord-270892-ycc3csyh	865	7	strategy	strategy	NN
cord-270892-ycc3csyh	865	8	for	for	IN
cord-270892-ycc3csyh	865	9	their	-PRON-	PRP$
cord-270892-ycc3csyh	865	10	discovery	discovery	NN
cord-270892-ycc3csyh	865	11	either	either	CC
cord-270892-ycc3csyh	865	12	starting	start	VBG
cord-270892-ycc3csyh	865	13	from	from	IN
cord-270892-ycc3csyh	865	14	a	a	DT
cord-270892-ycc3csyh	865	15	phenomenological	phenomenological	JJ
cord-270892-ycc3csyh	865	16	effect	effect	NN
cord-270892-ycc3csyh	865	17	,	,	,
cord-270892-ycc3csyh	865	18	e.g.	e.g.	IN
cord-270892-ycc3csyh	865	19	empirical	empirical	JJ
cord-270892-ycc3csyh	865	20	knowledge	knowledge	NN
cord-270892-ycc3csyh	865	21	from	from	IN
cord-270892-ycc3csyh	865	22	folk	folk	NN
cord-270892-ycc3csyh	865	23	medicine	medicine	NN
cord-270892-ycc3csyh	865	24	,	,	,
cord-270892-ycc3csyh	865	25	or	or	CC
cord-270892-ycc3csyh	865	26	from	from	IN
cord-270892-ycc3csyh	865	27	a	a	DT
cord-270892-ycc3csyh	865	28	targetbased	targetbased	JJ
cord-270892-ycc3csyh	865	29	molecular	molecular	JJ
cord-270892-ycc3csyh	865	30	level	level	NN
cord-270892-ycc3csyh	865	31	,	,	,
cord-270892-ycc3csyh	865	32	e.g.	e.g.	RB
cord-270892-ycc3csyh	865	33	ICAMs	icam	NNS
cord-270892-ycc3csyh	865	34	,	,	,
cord-270892-ycc3csyh	865	35	capsid	capsid	NN
cord-270892-ycc3csyh	865	36	binders	binder	NNS
cord-270892-ycc3csyh	865	37	,	,	,
cord-270892-ycc3csyh	865	38	and	and	CC
cord-270892-ycc3csyh	865	39	HRV	HRV	NNP
cord-270892-ycc3csyh	865	40	protease	protease	NN
cord-270892-ycc3csyh	865	41	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	865	42	.	.	.
cord-270892-ycc3csyh	866	1	Some	some	DT
cord-270892-ycc3csyh	866	2	of	of	IN
cord-270892-ycc3csyh	866	3	the	the	DT
cord-270892-ycc3csyh	866	4	outcomes	outcome	NNS
cord-270892-ycc3csyh	866	5	revealed	reveal	VBD
cord-270892-ycc3csyh	866	6	potent	potent	JJ
cord-270892-ycc3csyh	866	7	and	and	CC
cord-270892-ycc3csyh	866	8	promising	promising	JJ
cord-270892-ycc3csyh	866	9	activities	activity	NNS
cord-270892-ycc3csyh	866	10	that	that	WDT
cord-270892-ycc3csyh	866	11	partly	partly	RB
cord-270892-ycc3csyh	866	12	have	have	VBP
cord-270892-ycc3csyh	866	13	been	be	VBN
cord-270892-ycc3csyh	866	14	evaluated	evaluate	VBN
cord-270892-ycc3csyh	866	15	for	for	IN
cord-270892-ycc3csyh	866	16	the	the	DT
cord-270892-ycc3csyh	866	17	management	management	NN
cord-270892-ycc3csyh	866	18	of	of	IN
cord-270892-ycc3csyh	866	19	HRV	HRV	NNP
cord-270892-ycc3csyh	866	20	-	-	HYPH
cord-270892-ycc3csyh	866	21	induced	induce	VBN
cord-270892-ycc3csyh	866	22	common	common	JJ
cord-270892-ycc3csyh	866	23	colds	cold	NNS
cord-270892-ycc3csyh	866	24	in	in	IN
cord-270892-ycc3csyh	866	25	clinical	clinical	JJ
cord-270892-ycc3csyh	866	26	trials	trial	NNS
cord-270892-ycc3csyh	866	27	mainly	mainly	RB
cord-270892-ycc3csyh	866	28	with	with	IN
cord-270892-ycc3csyh	866	29	sobering	sobering	JJ
cord-270892-ycc3csyh	866	30	benefit	benefit	NN
cord-270892-ycc3csyh	866	31	.	.	.
cord-270892-ycc3csyh	867	1	Since	since	IN
cord-270892-ycc3csyh	867	2	the	the	DT
cord-270892-ycc3csyh	867	3	HRV	HRV	NNP
cord-270892-ycc3csyh	867	4	infection	infection	NN
cord-270892-ycc3csyh	867	5	is	be	VBZ
cord-270892-ycc3csyh	867	6	not	not	RB
cord-270892-ycc3csyh	867	7	life	life	NN
cord-270892-ycc3csyh	867	8	-	-	HYPH
cord-270892-ycc3csyh	867	9	threatening	threaten	VBG
cord-270892-ycc3csyh	867	10	in	in	IN
cord-270892-ycc3csyh	867	11	most	most	JJS
cord-270892-ycc3csyh	867	12	cases	case	NNS
cord-270892-ycc3csyh	867	13	,	,	,
cord-270892-ycc3csyh	867	14	a	a	DT
cord-270892-ycc3csyh	867	15	potential	potential	JJ
cord-270892-ycc3csyh	867	16	therapy	therapy	NN
cord-270892-ycc3csyh	867	17	has	have	VBZ
cord-270892-ycc3csyh	867	18	to	to	TO
cord-270892-ycc3csyh	867	19	be	be	VB
cord-270892-ycc3csyh	867	20	safe	safe	JJ
cord-270892-ycc3csyh	867	21	and	and	CC
cord-270892-ycc3csyh	867	22	effective	effective	JJ
cord-270892-ycc3csyh	867	23	with	with	IN
cord-270892-ycc3csyh	867	24	an	an	DT
cord-270892-ycc3csyh	867	25	almost	almost	RB
cord-270892-ycc3csyh	867	26	unrecognizable	unrecognizable	JJ
cord-270892-ycc3csyh	867	27	level	level	NN
cord-270892-ycc3csyh	867	28	of	of	IN
cord-270892-ycc3csyh	867	29	side	side	NN
cord-270892-ycc3csyh	867	30	effects	effect	NNS
cord-270892-ycc3csyh	867	31	.	.	.
cord-270892-ycc3csyh	868	1	These	these	DT
cord-270892-ycc3csyh	868	2	preconditions	precondition	NNS
cord-270892-ycc3csyh	868	3	render	render	VBP
cord-270892-ycc3csyh	868	4	the	the	DT
cord-270892-ycc3csyh	868	5	search	search	NN
cord-270892-ycc3csyh	868	6	for	for	IN
cord-270892-ycc3csyh	868	7	anti	anti	JJ
cord-270892-ycc3csyh	868	8	-	-	JJ
cord-270892-ycc3csyh	868	9	HRV	HRV	NNP
cord-270892-ycc3csyh	868	10	-	-	HYPH
cord-270892-ycc3csyh	868	11	agents	agent	NNS
cord-270892-ycc3csyh	868	12	into	into	IN
cord-270892-ycc3csyh	868	13	a	a	DT
cord-270892-ycc3csyh	868	14	high	high	JJ
cord-270892-ycc3csyh	868	15	challenging	challenging	JJ
cord-270892-ycc3csyh	868	16	endeavor	endeavor	NN
cord-270892-ycc3csyh	868	17	and	and	CC
cord-270892-ycc3csyh	868	18	explains	explain	VBZ
cord-270892-ycc3csyh	868	19	why	why	WRB
cord-270892-ycc3csyh	868	20	no	no	DT
cord-270892-ycc3csyh	868	21	antiviral	antiviral	JJ
cord-270892-ycc3csyh	868	22	agent	agent	NN
cord-270892-ycc3csyh	868	23	is	be	VBZ
cord-270892-ycc3csyh	868	24	approved	approve	VBN
cord-270892-ycc3csyh	868	25	for	for	IN
cord-270892-ycc3csyh	868	26	the	the	DT
cord-270892-ycc3csyh	868	27	prevention	prevention	NN
cord-270892-ycc3csyh	868	28	or	or	CC
cord-270892-ycc3csyh	868	29	treatment	treatment	NN
cord-270892-ycc3csyh	868	30	of	of	IN
cord-270892-ycc3csyh	868	31	HRV	HRV	NNP
cord-270892-ycc3csyh	868	32	-	-	HYPH
cord-270892-ycc3csyh	868	33	infection	infection	NN
cord-270892-ycc3csyh	868	34	until	until	IN
cord-270892-ycc3csyh	868	35	today	today	NN
cord-270892-ycc3csyh	868	36	,	,	,
cord-270892-ycc3csyh	868	37	despite	despite	IN
cord-270892-ycc3csyh	868	38	the	the	DT
cord-270892-ycc3csyh	868	39	significant	significant	JJ
cord-270892-ycc3csyh	868	40	efforts	effort	NNS
cord-270892-ycc3csyh	868	41	.	.	.
cord-270892-ycc3csyh	869	1	Moreover	moreover	RB
cord-270892-ycc3csyh	869	2	,	,	,
cord-270892-ycc3csyh	869	3	the	the	DT
cord-270892-ycc3csyh	869	4	high	high	JJ
cord-270892-ycc3csyh	869	5	variability	variability	NN
cord-270892-ycc3csyh	869	6	of	of	IN
cord-270892-ycc3csyh	869	7	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	869	8	suggests	suggest	VBZ
cord-270892-ycc3csyh	869	9	the	the	DT
cord-270892-ycc3csyh	869	10	need	need	NN
cord-270892-ycc3csyh	869	11	of	of	IN
cord-270892-ycc3csyh	869	12	more	more	JJR
cord-270892-ycc3csyh	869	13	than	than	IN
cord-270892-ycc3csyh	869	14	one	one	CD
cord-270892-ycc3csyh	869	15	active	active	JJ
cord-270892-ycc3csyh	869	16	principle	principle	NN
cord-270892-ycc3csyh	869	17	covering	cover	VBG
cord-270892-ycc3csyh	869	18	different	different	JJ
cord-270892-ycc3csyh	869	19	modes	mode	NNS
cord-270892-ycc3csyh	869	20	of	of	IN
cord-270892-ycc3csyh	869	21	action	action	NN
cord-270892-ycc3csyh	869	22	for	for	IN
cord-270892-ycc3csyh	869	23	an	an	DT
cord-270892-ycc3csyh	869	24	effective	effective	JJ
cord-270892-ycc3csyh	869	25	treatment	treatment	NN
cord-270892-ycc3csyh	869	26	.	.	.
cord-270892-ycc3csyh	870	1	Therefore	therefore	RB
cord-270892-ycc3csyh	870	2	,	,	,
cord-270892-ycc3csyh	870	3	there	there	EX
cord-270892-ycc3csyh	870	4	is	be	VBZ
cord-270892-ycc3csyh	870	5	a	a	DT
cord-270892-ycc3csyh	870	6	high	high	JJ
cord-270892-ycc3csyh	870	7	need	need	NN
cord-270892-ycc3csyh	870	8	for	for	IN
cord-270892-ycc3csyh	870	9	an	an	DT
cord-270892-ycc3csyh	870	10	ongoing	ongoing	JJ
cord-270892-ycc3csyh	870	11	search	search	NN
cord-270892-ycc3csyh	870	12	for	for	IN
cord-270892-ycc3csyh	870	13	new	new	JJ
cord-270892-ycc3csyh	870	14	synthetic	synthetic	NN
cord-270892-ycc3csyh	870	15	as	as	RB
cord-270892-ycc3csyh	870	16	well	well	RB
cord-270892-ycc3csyh	870	17	as	as	IN
cord-270892-ycc3csyh	870	18	natural	natural	JJ
cord-270892-ycc3csyh	870	19	compounds	compound	NNS
cord-270892-ycc3csyh	870	20	on	on	IN
cord-270892-ycc3csyh	870	21	a	a	DT
cord-270892-ycc3csyh	870	22	molecular	molecular	JJ
cord-270892-ycc3csyh	870	23	level	level	NN
cord-270892-ycc3csyh	870	24	.	.	.
cord-270892-ycc3csyh	871	1	The	the	DT
cord-270892-ycc3csyh	871	2	increasing	increase	VBG
cord-270892-ycc3csyh	871	3	knowledge	knowledge	NN
cord-270892-ycc3csyh	871	4	about	about	IN
cord-270892-ycc3csyh	871	5	the	the	DT
cord-270892-ycc3csyh	871	6	HRV	HRV	NNP
cord-270892-ycc3csyh	871	7	life	life	NN
cord-270892-ycc3csyh	871	8	cycle	cycle	NN
cord-270892-ycc3csyh	871	9	,	,	,
cord-270892-ycc3csyh	871	10	gene	gene	NN
cord-270892-ycc3csyh	871	11	,	,	,
cord-270892-ycc3csyh	871	12	and	and	CC
cord-270892-ycc3csyh	871	13	protein	protein	NN
cord-270892-ycc3csyh	871	14	sequence	sequence	NN
cord-270892-ycc3csyh	871	15	combined	combine	VBN
cord-270892-ycc3csyh	871	16	with	with	IN
cord-270892-ycc3csyh	871	17	the	the	DT
cord-270892-ycc3csyh	871	18	improved	improved	JJ
cord-270892-ycc3csyh	871	19	technologies	technology	NNS
cord-270892-ycc3csyh	871	20	in	in	IN
cord-270892-ycc3csyh	871	21	the	the	DT
cord-270892-ycc3csyh	871	22	field	field	NN
cord-270892-ycc3csyh	871	23	of	of	IN
cord-270892-ycc3csyh	871	24	experimental	experimental	JJ
cord-270892-ycc3csyh	871	25	and	and	CC
cord-270892-ycc3csyh	871	26	computational	computational	JJ
cord-270892-ycc3csyh	871	27	methods	method	NNS
cord-270892-ycc3csyh	871	28	have	have	VBP
cord-270892-ycc3csyh	871	29	continuously	continuously	RB
cord-270892-ycc3csyh	871	30	enabled	enable	VBN
cord-270892-ycc3csyh	871	31	further	further	JJ
cord-270892-ycc3csyh	871	32	insights	insight	NNS
cord-270892-ycc3csyh	871	33	into	into	IN
cord-270892-ycc3csyh	871	34	the	the	DT
cord-270892-ycc3csyh	871	35	spectacular	spectacular	JJ
cord-270892-ycc3csyh	871	36	world	world	NN
cord-270892-ycc3csyh	871	37	of	of	IN
cord-270892-ycc3csyh	871	38	HRV	HRV	NNP
cord-270892-ycc3csyh	871	39	.	.	.
cord-270892-ycc3csyh	872	1	Only	only	RB
cord-270892-ycc3csyh	872	2	with	with	IN
cord-270892-ycc3csyh	872	3	this	this	DT
cord-270892-ycc3csyh	872	4	fundamental	fundamental	JJ
cord-270892-ycc3csyh	872	5	research	research	NN
cord-270892-ycc3csyh	872	6	,	,	,
cord-270892-ycc3csyh	872	7	virtual	virtual	JJ
cord-270892-ycc3csyh	872	8	screening	screening	NN
cord-270892-ycc3csyh	872	9	approaches	approach	NNS
cord-270892-ycc3csyh	872	10	,	,	,
cord-270892-ycc3csyh	872	11	such	such	JJ
cord-270892-ycc3csyh	872	12	as	as	IN
cord-270892-ycc3csyh	872	13	QSAR	QSAR	NNP
cord-270892-ycc3csyh	872	14	,	,	,
cord-270892-ycc3csyh	872	15	pharmacophore	pharmacophore	NN
cord-270892-ycc3csyh	872	16	-	-	HYPH
cord-270892-ycc3csyh	872	17	and	and	CC
cord-270892-ycc3csyh	872	18	docking	docking	NN
cord-270892-ycc3csyh	872	19	-	-	HYPH
cord-270892-ycc3csyh	872	20	based	base	VBN
cord-270892-ycc3csyh	872	21	screening	screening	NN
cord-270892-ycc3csyh	872	22	cycles	cycle	NNS
cord-270892-ycc3csyh	872	23	,	,	,
cord-270892-ycc3csyh	872	24	or	or	CC
cord-270892-ycc3csyh	872	25	computational	computational	JJ
cord-270892-ycc3csyh	872	26	compound	compound	NN
cord-270892-ycc3csyh	872	27	design	design	NN
cord-270892-ycc3csyh	872	28	,	,	,
cord-270892-ycc3csyh	872	29	are	be	VBP
cord-270892-ycc3csyh	872	30	applicable	applicable	JJ
cord-270892-ycc3csyh	872	31	on	on	IN
cord-270892-ycc3csyh	872	32	a	a	DT
cord-270892-ycc3csyh	872	33	rational	rational	JJ
cord-270892-ycc3csyh	872	34	base	base	NN
cord-270892-ycc3csyh	872	35	.	.	.
cord-270892-ycc3csyh	873	1	With	with	IN
cord-270892-ycc3csyh	873	2	the	the	DT
cord-270892-ycc3csyh	873	3	gained	gain	VBN
cord-270892-ycc3csyh	873	4	expertise	expertise	NN
cord-270892-ycc3csyh	873	5	from	from	IN
cord-270892-ycc3csyh	873	6	different	different	JJ
cord-270892-ycc3csyh	873	7	disciplines	discipline	NNS
cord-270892-ycc3csyh	873	8	and	and	CC
cord-270892-ycc3csyh	873	9	an	an	DT
cord-270892-ycc3csyh	873	10	adequate	adequate	JJ
cord-270892-ycc3csyh	873	11	infrastructure	infrastructure	NN
cord-270892-ycc3csyh	873	12	for	for	IN
cord-270892-ycc3csyh	873	13	further	further	JJ
cord-270892-ycc3csyh	873	14	research	research	NN
cord-270892-ycc3csyh	873	15	,	,	,
cord-270892-ycc3csyh	873	16	it	-PRON-	PRP
cord-270892-ycc3csyh	873	17	is	be	VBZ
cord-270892-ycc3csyh	873	18	encouraging	encouraging	JJ
cord-270892-ycc3csyh	873	19	to	to	TO
cord-270892-ycc3csyh	873	20	hope	hope	VB
cord-270892-ycc3csyh	873	21	that	that	IN
cord-270892-ycc3csyh	873	22	discovery	discovery	NN
cord-270892-ycc3csyh	873	23	and	and	CC
cord-270892-ycc3csyh	873	24	clinical	clinical	JJ
cord-270892-ycc3csyh	873	25	development	development	NN
cord-270892-ycc3csyh	873	26	efforts	effort	NNS
cord-270892-ycc3csyh	873	27	will	will	MD
cord-270892-ycc3csyh	873	28	continue	continue	VB
cord-270892-ycc3csyh	873	29	in	in	IN
cord-270892-ycc3csyh	873	30	the	the	DT
cord-270892-ycc3csyh	873	31	search	search	NN
cord-270892-ycc3csyh	873	32	for	for	IN
cord-270892-ycc3csyh	873	33	agents	agent	NNS
cord-270892-ycc3csyh	873	34	that	that	WDT
cord-270892-ycc3csyh	873	35	may	may	MD
cord-270892-ycc3csyh	873	36	treat	treat	VB
cord-270892-ycc3csyh	873	37	or	or	CC
cord-270892-ycc3csyh	873	38	prevent	prevent	VB
cord-270892-ycc3csyh	873	39	the	the	DT
cord-270892-ycc3csyh	873	40	annoying	annoying	JJ
cord-270892-ycc3csyh	873	41	common	common	JJ
cord-270892-ycc3csyh	873	42	cold	cold	NN
cord-270892-ycc3csyh	873	43	.	.	.
cord-270892-ycc3csyh	874	1	Picornavirales	Picornavirales	NNP
cord-270892-ycc3csyh	874	2	,	,	,
cord-270892-ycc3csyh	874	3	a	a	DT
cord-270892-ycc3csyh	874	4	proposed	propose	VBN
cord-270892-ycc3csyh	874	5	order	order	NN
cord-270892-ycc3csyh	874	6	of	of	IN
cord-270892-ycc3csyh	874	7	positive	positive	JJ
cord-270892-ycc3csyh	874	8	-	-	HYPH
cord-270892-ycc3csyh	874	9	sense	sense	NN
cord-270892-ycc3csyh	874	10	single	single	JJ
cord-270892-ycc3csyh	874	11	-	-	HYPH
cord-270892-ycc3csyh	874	12	stranded	strand	VBN
cord-270892-ycc3csyh	874	13	RNA	RNA	NNP
cord-270892-ycc3csyh	874	14	viruses	virus	NNS
cord-270892-ycc3csyh	874	15	with	with	IN
cord-270892-ycc3csyh	874	16	a	a	DT
cord-270892-ycc3csyh	874	17	pseudo	pseudo	JJ
cord-270892-ycc3csyh	874	18	-	-	HYPH
cord-270892-ycc3csyh	874	19	T	t	NN
cord-270892-ycc3csyh	874	20	5	5	CD
cord-270892-ycc3csyh	874	21	3	3	CD
cord-270892-ycc3csyh	874	22	virion	virion	NN
cord-270892-ycc3csyh	874	23	architecture	architecture	NN
cord-270892-ycc3csyh	874	24	Global	global	JJ
cord-270892-ycc3csyh	874	25	distribution	distribution	NN
cord-270892-ycc3csyh	874	26	of	of	IN
cord-270892-ycc3csyh	874	27	novel	novel	JJ
cord-270892-ycc3csyh	874	28	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	874	29	genotype	genotype	NN
cord-270892-ycc3csyh	874	30	Genome	Genome	NNP
cord-270892-ycc3csyh	874	31	-	-	HYPH
cord-270892-ycc3csyh	874	32	wide	wide	JJ
cord-270892-ycc3csyh	874	33	diversity	diversity	NN
cord-270892-ycc3csyh	874	34	and	and	CC
cord-270892-ycc3csyh	874	35	selective	selective	JJ
cord-270892-ycc3csyh	874	36	pressure	pressure	NN
cord-270892-ycc3csyh	874	37	in	in	IN
cord-270892-ycc3csyh	874	38	the	the	DT
cord-270892-ycc3csyh	874	39	human	human	JJ
cord-270892-ycc3csyh	874	40	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	874	41	Clinical	clinical	JJ
cord-270892-ycc3csyh	874	42	features	feature	NNS
cord-270892-ycc3csyh	874	43	and	and	CC
cord-270892-ycc3csyh	874	44	complete	complete	JJ
cord-270892-ycc3csyh	874	45	genome	genome	NN
cord-270892-ycc3csyh	874	46	characterization	characterization	NN
cord-270892-ycc3csyh	874	47	of	of	IN
cord-270892-ycc3csyh	874	48	a	a	DT
cord-270892-ycc3csyh	874	49	distinct	distinct	JJ
cord-270892-ycc3csyh	874	50	human	human	JJ
cord-270892-ycc3csyh	874	51	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	874	52	(	(	-LRB-
cord-270892-ycc3csyh	874	53	HRV	HRV	NNP
cord-270892-ycc3csyh	874	54	)	)	-RRB-
cord-270892-ycc3csyh	874	55	genetic	genetic	JJ
cord-270892-ycc3csyh	874	56	cluster	cluster	NN
cord-270892-ycc3csyh	874	57	,	,	,
cord-270892-ycc3csyh	874	58	probably	probably	RB
cord-270892-ycc3csyh	874	59	representing	represent	VBG
cord-270892-ycc3csyh	874	60	a	a	DT
cord-270892-ycc3csyh	874	61	previously	previously	RB
cord-270892-ycc3csyh	874	62	undetected	undetected	JJ
cord-270892-ycc3csyh	874	63	HRV	HRV	NNP
cord-270892-ycc3csyh	874	64	species	specie	NNS
cord-270892-ycc3csyh	874	65	,	,	,
cord-270892-ycc3csyh	874	66	HRV	HRV	NNP
cord-270892-ycc3csyh	874	67	-	-	HYPH
cord-270892-ycc3csyh	874	68	C	C	NNP
cord-270892-ycc3csyh	874	69	,	,	,
cord-270892-ycc3csyh	874	70	associated	associate	VBN
cord-270892-ycc3csyh	874	71	with	with	IN
cord-270892-ycc3csyh	874	72	acute	acute	JJ
cord-270892-ycc3csyh	874	73	respiratory	respiratory	JJ
cord-270892-ycc3csyh	874	74	illness	illness	NN
cord-270892-ycc3csyh	874	75	in	in	IN
cord-270892-ycc3csyh	874	76	children	child	NNS
cord-270892-ycc3csyh	874	77	Characterisation	Characterisation	NNP
cord-270892-ycc3csyh	874	78	of	of	IN
cord-270892-ycc3csyh	874	79	a	a	DT
cord-270892-ycc3csyh	874	80	newly	newly	RB
cord-270892-ycc3csyh	874	81	identified	identify	VBN
cord-270892-ycc3csyh	874	82	human	human	JJ
cord-270892-ycc3csyh	874	83	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	874	84	,	,	,
cord-270892-ycc3csyh	874	85	HRV	HRV	NNP
cord-270892-ycc3csyh	874	86	-	-	HYPH
cord-270892-ycc3csyh	874	87	QPM	QPM	NNP
cord-270892-ycc3csyh	874	88	,	,	,
cord-270892-ycc3csyh	874	89	discovered	discover	VBN
cord-270892-ycc3csyh	874	90	in	in	IN
cord-270892-ycc3csyh	874	91	infants	infant	NNS
cord-270892-ycc3csyh	874	92	with	with	IN
cord-270892-ycc3csyh	874	93	bronchiolitis	bronchiolitis	NN
cord-270892-ycc3csyh	874	94	Distinguishing	distinguish	VBG
cord-270892-ycc3csyh	874	95	molecular	molecular	JJ
cord-270892-ycc3csyh	874	96	features	feature	NNS
cord-270892-ycc3csyh	874	97	and	and	CC
cord-270892-ycc3csyh	874	98	clinical	clinical	JJ
cord-270892-ycc3csyh	874	99	characteristics	characteristic	NNS
cord-270892-ycc3csyh	874	100	of	of	IN
cord-270892-ycc3csyh	874	101	a	a	DT
cord-270892-ycc3csyh	874	102	putative	putative	JJ
cord-270892-ycc3csyh	874	103	new	new	JJ
cord-270892-ycc3csyh	874	104	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	874	105	species	specie	NNS
cord-270892-ycc3csyh	874	106	,	,	,
cord-270892-ycc3csyh	874	107	human	human	JJ
cord-270892-ycc3csyh	874	108	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	874	109	C	C	NNP
cord-270892-ycc3csyh	874	110	(	(	-LRB-
cord-270892-ycc3csyh	874	111	HRV	HRV	NNP
cord-270892-ycc3csyh	874	112	C	C	NNP
cord-270892-ycc3csyh	874	113	)	)	-RRB-
cord-270892-ycc3csyh	874	114	Sequencing	sequencing	NN
cord-270892-ycc3csyh	874	115	and	and	CC
cord-270892-ycc3csyh	874	116	analyses	analysis	NNS
cord-270892-ycc3csyh	874	117	of	of	IN
cord-270892-ycc3csyh	874	118	all	all	DT
cord-270892-ycc3csyh	874	119	known	know	VBN
cord-270892-ycc3csyh	874	120	human	human	JJ
cord-270892-ycc3csyh	874	121	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	874	122	genomes	genome	NNS
cord-270892-ycc3csyh	874	123	reveal	reveal	VBP
cord-270892-ycc3csyh	874	124	structure	structure	NN
cord-270892-ycc3csyh	874	125	and	and	CC
cord-270892-ycc3csyh	874	126	evolution	evolution	NN
cord-270892-ycc3csyh	874	127	Comparison	comparison	NN
cord-270892-ycc3csyh	874	128	of	of	IN
cord-270892-ycc3csyh	874	129	classic	classic	JJ
cord-270892-ycc3csyh	874	130	and	and	CC
cord-270892-ycc3csyh	874	131	molecular	molecular	JJ
cord-270892-ycc3csyh	874	132	approaches	approach	NNS
cord-270892-ycc3csyh	874	133	for	for	IN
cord-270892-ycc3csyh	874	134	the	the	DT
cord-270892-ycc3csyh	874	135	identification	identification	NN
cord-270892-ycc3csyh	874	136	of	of	IN
cord-270892-ycc3csyh	874	137	untypeable	untypeable	NNP
cord-270892-ycc3csyh	874	138	enteroviruses	enteroviruses	NNP
cord-270892-ycc3csyh	874	139	Molecular	Molecular	NNP
cord-270892-ycc3csyh	874	140	evolution	evolution	NN
cord-270892-ycc3csyh	874	141	of	of	IN
cord-270892-ycc3csyh	874	142	the	the	DT
cord-270892-ycc3csyh	874	143	human	human	JJ
cord-270892-ycc3csyh	874	144	enteroviruses	enterovirus	NNS
cord-270892-ycc3csyh	874	145	:	:	:
cord-270892-ycc3csyh	874	146	Correlation	correlation	NN
cord-270892-ycc3csyh	874	147	of	of	IN
cord-270892-ycc3csyh	874	148	serotype	serotype	NN
cord-270892-ycc3csyh	874	149	with	with	IN
cord-270892-ycc3csyh	874	150	VP1	vp1	NN
cord-270892-ycc3csyh	874	151	sequence	sequence	NN
cord-270892-ycc3csyh	874	152	and	and	CC
cord-270892-ycc3csyh	874	153	application	application	NN
cord-270892-ycc3csyh	874	154	to	to	IN
cord-270892-ycc3csyh	874	155	picornavirus	picornavirus	NNP
cord-270892-ycc3csyh	874	156	classification	classification	NN
cord-270892-ycc3csyh	874	157	Typing	typing	NN
cord-270892-ycc3csyh	874	158	of	of	IN
cord-270892-ycc3csyh	874	159	human	human	JJ
cord-270892-ycc3csyh	874	160	enteroviruses	enterovirus	NNS
cord-270892-ycc3csyh	874	161	by	by	IN
cord-270892-ycc3csyh	874	162	partial	partial	JJ
cord-270892-ycc3csyh	874	163	sequencing	sequencing	NN
cord-270892-ycc3csyh	874	164	of	of	IN
cord-270892-ycc3csyh	874	165	VP1	VP1	NNP
cord-270892-ycc3csyh	874	166	Molecular	molecular	JJ
cord-270892-ycc3csyh	874	167	relationships	relationship	NNS
cord-270892-ycc3csyh	874	168	between	between	IN
cord-270892-ycc3csyh	874	169	21	21	CD
cord-270892-ycc3csyh	874	170	human	human	JJ
cord-270892-ycc3csyh	874	171	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	874	172	serotypes	serotypes	NN
cord-270892-ycc3csyh	874	173	VP1	vp1	NN
cord-270892-ycc3csyh	874	174	sequencing	sequencing	NN
cord-270892-ycc3csyh	874	175	of	of	IN
cord-270892-ycc3csyh	874	176	all	all	DT
cord-270892-ycc3csyh	874	177	human	human	JJ
cord-270892-ycc3csyh	874	178	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	874	179	serotypes	serotype	NNS
cord-270892-ycc3csyh	874	180	:	:	:
cord-270892-ycc3csyh	874	181	Insights	insight	NNS
cord-270892-ycc3csyh	874	182	into	into	IN
cord-270892-ycc3csyh	874	183	genus	genus	NN
cord-270892-ycc3csyh	874	184	phylogeny	phylogeny	NN
cord-270892-ycc3csyh	874	185	and	and	CC
cord-270892-ycc3csyh	874	186	susceptibility	susceptibility	NN
cord-270892-ycc3csyh	874	187	to	to	IN
cord-270892-ycc3csyh	874	188	antiviral	antiviral	JJ
cord-270892-ycc3csyh	874	189	capsid	capsid	RB
cord-270892-ycc3csyh	874	190	-	-	HYPH
cord-270892-ycc3csyh	874	191	binding	bind	VBG
cord-270892-ycc3csyh	874	192	compounds	compound	NNS
cord-270892-ycc3csyh	875	1	Molecular	molecular	JJ
cord-270892-ycc3csyh	875	2	cloning	cloning	NN
cord-270892-ycc3csyh	875	3	and	and	CC
cord-270892-ycc3csyh	875	4	complete	complete	JJ
cord-270892-ycc3csyh	875	5	sequence	sequence	NN
cord-270892-ycc3csyh	875	6	determination	determination	NN
cord-270892-ycc3csyh	875	7	of	of	IN
cord-270892-ycc3csyh	875	8	RNA	RNA	NNP
cord-270892-ycc3csyh	875	9	genome	genome	NN
cord-270892-ycc3csyh	875	10	of	of	IN
cord-270892-ycc3csyh	875	11	human	human	JJ
cord-270892-ycc3csyh	875	12	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	875	13	type	type	NN
cord-270892-ycc3csyh	875	14	14	14	CD
cord-270892-ycc3csyh	875	15	Evolutionary	evolutionary	JJ
cord-270892-ycc3csyh	875	16	relationships	relationship	NNS
cord-270892-ycc3csyh	875	17	within	within	IN
cord-270892-ycc3csyh	875	18	the	the	DT
cord-270892-ycc3csyh	875	19	human	human	JJ
cord-270892-ycc3csyh	875	20	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	875	21	genus	genus	NN
cord-270892-ycc3csyh	875	22	:	:	:
cord-270892-ycc3csyh	876	1	Comparison	comparison	NN
cord-270892-ycc3csyh	876	2	of	of	IN
cord-270892-ycc3csyh	876	3	serotypes	serotypes	NN
cord-270892-ycc3csyh	876	4	89	89	CD
cord-270892-ycc3csyh	876	5	,	,	,
cord-270892-ycc3csyh	876	6	2	2	CD
cord-270892-ycc3csyh	876	7	,	,	,
cord-270892-ycc3csyh	876	8	and	and	CC
cord-270892-ycc3csyh	876	9	14	14	CD
cord-270892-ycc3csyh	876	10	Amino	amino	NN
cord-270892-ycc3csyh	876	11	acid	acid	NN
cord-270892-ycc3csyh	876	12	changes	change	NNS
cord-270892-ycc3csyh	876	13	in	in	IN
cord-270892-ycc3csyh	876	14	proteins	protein	NNS
cord-270892-ycc3csyh	876	15	2B	2b	CD
cord-270892-ycc3csyh	876	16	and	and	CC
cord-270892-ycc3csyh	876	17	3A	3A	NNP
cord-270892-ycc3csyh	876	18	mediate	mediate	VB
cord-270892-ycc3csyh	876	19	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	876	20	type	type	NN
cord-270892-ycc3csyh	876	21	39	39	CD
cord-270892-ycc3csyh	876	22	growth	growth	NN
cord-270892-ycc3csyh	876	23	in	in	IN
cord-270892-ycc3csyh	876	24	mouse	mouse	NN
cord-270892-ycc3csyh	876	25	cells	cell	NNS
cord-270892-ycc3csyh	877	1	The	the	DT
cord-270892-ycc3csyh	877	2	nucleotide	nucleotide	JJ
cord-270892-ycc3csyh	877	3	sequence	sequence	NN
cord-270892-ycc3csyh	877	4	of	of	IN
cord-270892-ycc3csyh	877	5	human	human	JJ
cord-270892-ycc3csyh	877	6	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	877	7	1B	1b	NN
cord-270892-ycc3csyh	877	8	:	:	:
cord-270892-ycc3csyh	878	1	Molecular	molecular	JJ
cord-270892-ycc3csyh	878	2	relationships	relationship	NNS
cord-270892-ycc3csyh	878	3	within	within	IN
cord-270892-ycc3csyh	878	4	the	the	DT
cord-270892-ycc3csyh	878	5	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	878	6	genus	genus	NN
cord-270892-ycc3csyh	878	7	Complete	complete	JJ
cord-270892-ycc3csyh	878	8	sequence	sequence	NN
cord-270892-ycc3csyh	878	9	of	of	IN
cord-270892-ycc3csyh	878	10	the	the	DT
cord-270892-ycc3csyh	878	11	RNA	RNA	NNP
cord-270892-ycc3csyh	878	12	genome	genome	NN
cord-270892-ycc3csyh	878	13	of	of	IN
cord-270892-ycc3csyh	878	14	human	human	JJ
cord-270892-ycc3csyh	878	15	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	878	16	16	16	CD
cord-270892-ycc3csyh	878	17	,	,	,
cord-270892-ycc3csyh	878	18	a	a	DT
cord-270892-ycc3csyh	878	19	clinically	clinically	RB
cord-270892-ycc3csyh	878	20	useful	useful	JJ
cord-270892-ycc3csyh	878	21	common	common	JJ
cord-270892-ycc3csyh	878	22	cold	cold	JJ
cord-270892-ycc3csyh	878	23	virus	virus	NN
cord-270892-ycc3csyh	878	24	belonging	belong	VBG
cord-270892-ycc3csyh	878	25	to	to	IN
cord-270892-ycc3csyh	878	26	the	the	DT
cord-270892-ycc3csyh	878	27	ICAM-1	ICAM-1	NNP
cord-270892-ycc3csyh	878	28	receptor	receptor	NN
cord-270892-ycc3csyh	878	29	group	group	NN
cord-270892-ycc3csyh	878	30	Human	Human	NNP
cord-270892-ycc3csyh	878	31	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	878	32	2	2	CD
cord-270892-ycc3csyh	878	33	:	:	:
cord-270892-ycc3csyh	878	34	Complete	complete	JJ
cord-270892-ycc3csyh	878	35	nucleotide	nucleotide	JJ
cord-270892-ycc3csyh	878	36	sequence	sequence	NN
cord-270892-ycc3csyh	878	37	and	and	CC
cord-270892-ycc3csyh	878	38	proteolytic	proteolytic	JJ
cord-270892-ycc3csyh	878	39	processing	processing	NN
cord-270892-ycc3csyh	878	40	signals	signal	NNS
cord-270892-ycc3csyh	878	41	in	in	IN
cord-270892-ycc3csyh	878	42	the	the	DT
cord-270892-ycc3csyh	878	43	capsid	capsid	JJ
cord-270892-ycc3csyh	878	44	protein	protein	NN
cord-270892-ycc3csyh	878	45	region	region	NN
cord-270892-ycc3csyh	879	1	The	the	DT
cord-270892-ycc3csyh	879	2	complete	complete	JJ
cord-270892-ycc3csyh	879	3	nucleotide	nucleotide	JJ
cord-270892-ycc3csyh	879	4	sequence	sequence	NN
cord-270892-ycc3csyh	879	5	of	of	IN
cord-270892-ycc3csyh	879	6	a	a	DT
cord-270892-ycc3csyh	879	7	common	common	JJ
cord-270892-ycc3csyh	879	8	cold	cold	JJ
cord-270892-ycc3csyh	879	9	virus	virus	NN
cord-270892-ycc3csyh	879	10	:	:	:
cord-270892-ycc3csyh	879	11	Human	human	JJ
cord-270892-ycc3csyh	879	12	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	879	13	14	14	CD
cord-270892-ycc3csyh	879	14	New	New	NNP
cord-270892-ycc3csyh	879	15	complete	complete	JJ
cord-270892-ycc3csyh	879	16	genome	genome	NN
cord-270892-ycc3csyh	879	17	sequences	sequence	NNS
cord-270892-ycc3csyh	879	18	of	of	IN
cord-270892-ycc3csyh	879	19	human	human	JJ
cord-270892-ycc3csyh	879	20	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	879	21	shed	shed	VBP
cord-270892-ycc3csyh	879	22	light	light	NN
cord-270892-ycc3csyh	879	23	on	on	IN
cord-270892-ycc3csyh	879	24	their	-PRON-	PRP$
cord-270892-ycc3csyh	879	25	phylogeny	phylogeny	NN
cord-270892-ycc3csyh	879	26	and	and	CC
cord-270892-ycc3csyh	879	27	genomic	genomic	NN
cord-270892-ycc3csyh	879	28	features	feature	VBZ
cord-270892-ycc3csyh	879	29	Genetic	genetic	JJ
cord-270892-ycc3csyh	879	30	clustering	clustering	NN
cord-270892-ycc3csyh	879	31	of	of	IN
cord-270892-ycc3csyh	879	32	all	all	DT
cord-270892-ycc3csyh	879	33	102	102	CD
cord-270892-ycc3csyh	879	34	human	human	JJ
cord-270892-ycc3csyh	879	35	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	879	36	prototype	prototype	NN
cord-270892-ycc3csyh	879	37	strains	strain	NNS
cord-270892-ycc3csyh	879	38	:	:	:
cord-270892-ycc3csyh	880	1	Serotype	Serotype	NNP
cord-270892-ycc3csyh	880	2	87	87	CD
cord-270892-ycc3csyh	880	3	is	be	VBZ
cord-270892-ycc3csyh	880	4	close	close	JJ
cord-270892-ycc3csyh	880	5	to	to	IN
cord-270892-ycc3csyh	880	6	human	human	JJ
cord-270892-ycc3csyh	880	7	enterovirus	enterovirus	NN
cord-270892-ycc3csyh	880	8	70	70	CD
cord-270892-ycc3csyh	881	1	The	the	DT
cord-270892-ycc3csyh	881	2	common	common	JJ
cord-270892-ycc3csyh	881	3	cold	cold	JJ
cord-270892-ycc3csyh	881	4	Phylogenetic	Phylogenetic	NNP
cord-270892-ycc3csyh	881	5	analysis	analysis	NN
cord-270892-ycc3csyh	881	6	of	of	IN
cord-270892-ycc3csyh	881	7	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	881	8	isolates	isolate	NNS
cord-270892-ycc3csyh	881	9	collected	collect	VBN
cord-270892-ycc3csyh	881	10	during	during	IN
cord-270892-ycc3csyh	881	11	successive	successive	JJ
cord-270892-ycc3csyh	881	12	epidemic	epidemic	NN
cord-270892-ycc3csyh	881	13	seasons	season	NNS
cord-270892-ycc3csyh	882	1	A	a	DT
cord-270892-ycc3csyh	882	2	diverse	diverse	JJ
cord-270892-ycc3csyh	882	3	group	group	NN
cord-270892-ycc3csyh	882	4	of	of	IN
cord-270892-ycc3csyh	882	5	previously	previously	RB
cord-270892-ycc3csyh	882	6	unrecognized	unrecognized	JJ
cord-270892-ycc3csyh	882	7	human	human	JJ
cord-270892-ycc3csyh	882	8	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	882	9	are	be	VBP
cord-270892-ycc3csyh	882	10	common	common	JJ
cord-270892-ycc3csyh	882	11	causes	cause	NNS
cord-270892-ycc3csyh	882	12	of	of	IN
cord-270892-ycc3csyh	882	13	respiratory	respiratory	JJ
cord-270892-ycc3csyh	882	14	illnesses	illness	NNS
cord-270892-ycc3csyh	882	15	in	in	IN
cord-270892-ycc3csyh	882	16	infants	infant	NNS
cord-270892-ycc3csyh	882	17	Rhinovirus	Rhinovirus	NNP
cord-270892-ycc3csyh	882	18	transmission	transmission	NN
cord-270892-ycc3csyh	882	19	within	within	IN
cord-270892-ycc3csyh	882	20	families	family	NNS
cord-270892-ycc3csyh	882	21	with	with	IN
cord-270892-ycc3csyh	882	22	children	child	NNS
cord-270892-ycc3csyh	882	23	:	:	:
cord-270892-ycc3csyh	882	24	incidence	incidence	NN
cord-270892-ycc3csyh	882	25	of	of	IN
cord-270892-ycc3csyh	882	26	symptomatic	symptomatic	JJ
cord-270892-ycc3csyh	882	27	and	and	CC
cord-270892-ycc3csyh	882	28	asymptomatic	asymptomatic	JJ
cord-270892-ycc3csyh	882	29	infections	infection	NNS
cord-270892-ycc3csyh	883	1	A	a	DT
cord-270892-ycc3csyh	883	2	recently	recently	RB
cord-270892-ycc3csyh	883	3	identified	identify	VBN
cord-270892-ycc3csyh	883	4	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	883	5	genotype	genotype	NN
cord-270892-ycc3csyh	883	6	is	be	VBZ
cord-270892-ycc3csyh	883	7	associated	associate	VBN
cord-270892-ycc3csyh	883	8	with	with	IN
cord-270892-ycc3csyh	883	9	severe	severe	JJ
cord-270892-ycc3csyh	883	10	respiratory	respiratory	JJ
cord-270892-ycc3csyh	883	11	-	-	HYPH
cord-270892-ycc3csyh	883	12	tract	tract	NN
cord-270892-ycc3csyh	883	13	infection	infection	NN
cord-270892-ycc3csyh	883	14	in	in	IN
cord-270892-ycc3csyh	883	15	children	child	NNS
cord-270892-ycc3csyh	883	16	in	in	IN
cord-270892-ycc3csyh	883	17	Germany	Germany	NNP
cord-270892-ycc3csyh	884	1	Acute	acute	JJ
cord-270892-ycc3csyh	884	2	respiratory	respiratory	JJ
cord-270892-ycc3csyh	884	3	illness	illness	NN
cord-270892-ycc3csyh	884	4	in	in	IN
cord-270892-ycc3csyh	884	5	the	the	DT
cord-270892-ycc3csyh	884	6	community	community	NN
cord-270892-ycc3csyh	884	7	.	.	.
cord-270892-ycc3csyh	885	1	Frequency	frequency	NN
cord-270892-ycc3csyh	885	2	of	of	IN
cord-270892-ycc3csyh	885	3	illness	illness	NN
cord-270892-ycc3csyh	885	4	and	and	CC
cord-270892-ycc3csyh	885	5	the	the	DT
cord-270892-ycc3csyh	885	6	agents	agent	NNS
cord-270892-ycc3csyh	885	7	involved	involve	VBD
cord-270892-ycc3csyh	885	8	Sinusitis	sinusitis	NN
cord-270892-ycc3csyh	885	9	in	in	IN
cord-270892-ycc3csyh	885	10	the	the	DT
cord-270892-ycc3csyh	885	11	common	common	JJ
cord-270892-ycc3csyh	885	12	cold	cold	JJ
cord-270892-ycc3csyh	885	13	Viral	viral	JJ
cord-270892-ycc3csyh	885	14	etiology	etiology	NN
cord-270892-ycc3csyh	885	15	of	of	IN
cord-270892-ycc3csyh	885	16	common	common	JJ
cord-270892-ycc3csyh	885	17	cold	cold	NN
cord-270892-ycc3csyh	885	18	in	in	IN
cord-270892-ycc3csyh	885	19	children	child	NNS
cord-270892-ycc3csyh	885	20	A	a	DT
cord-270892-ycc3csyh	885	21	case	case	NN
cord-270892-ycc3csyh	885	22	-	-	HYPH
cord-270892-ycc3csyh	885	23	control	control	NN
cord-270892-ycc3csyh	885	24	study	study	NN
cord-270892-ycc3csyh	885	25	of	of	IN
cord-270892-ycc3csyh	885	26	acute	acute	JJ
cord-270892-ycc3csyh	885	27	respiratory	respiratory	JJ
cord-270892-ycc3csyh	885	28	tract	tract	NN
cord-270892-ycc3csyh	885	29	infection	infection	NN
cord-270892-ycc3csyh	885	30	in	in	IN
cord-270892-ycc3csyh	885	31	general	general	JJ
cord-270892-ycc3csyh	885	32	practice	practice	NN
cord-270892-ycc3csyh	885	33	patients	patient	NNS
cord-270892-ycc3csyh	885	34	in	in	IN
cord-270892-ycc3csyh	885	35	The	the	DT
cord-270892-ycc3csyh	885	36	Netherlands	Netherlands	NNP
cord-270892-ycc3csyh	885	37	Community	Community	NNP
cord-270892-ycc3csyh	885	38	-	-	HYPH
cord-270892-ycc3csyh	885	39	acquired	acquire	VBN
cord-270892-ycc3csyh	885	40	pathogens	pathogen	NNS
cord-270892-ycc3csyh	885	41	associated	associate	VBN
cord-270892-ycc3csyh	885	42	with	with	IN
cord-270892-ycc3csyh	885	43	prolonged	prolonged	JJ
cord-270892-ycc3csyh	885	44	coughing	coughing	NN
cord-270892-ycc3csyh	885	45	in	in	IN
cord-270892-ycc3csyh	885	46	children	child	NNS
cord-270892-ycc3csyh	885	47	:	:	:
cord-270892-ycc3csyh	885	48	a	a	DT
cord-270892-ycc3csyh	885	49	prospective	prospective	JJ
cord-270892-ycc3csyh	885	50	cohort	cohort	NN
cord-270892-ycc3csyh	885	51	study	study	NN
cord-270892-ycc3csyh	885	52	Frequency	Frequency	NNP
cord-270892-ycc3csyh	885	53	and	and	CC
cord-270892-ycc3csyh	885	54	natural	natural	JJ
cord-270892-ycc3csyh	885	55	history	history	NN
cord-270892-ycc3csyh	885	56	of	of	IN
cord-270892-ycc3csyh	885	57	rhinovirus	rhinovirus	JJ
cord-270892-ycc3csyh	885	58	infections	infection	NNS
cord-270892-ycc3csyh	885	59	in	in	IN
cord-270892-ycc3csyh	885	60	adults	adult	NNS
cord-270892-ycc3csyh	885	61	during	during	IN
cord-270892-ycc3csyh	885	62	autumn	autumn	NN
cord-270892-ycc3csyh	885	63	Viruses	virus	NNS
cord-270892-ycc3csyh	885	64	and	and	CC
cord-270892-ycc3csyh	885	65	bacteria	bacteria	NNS
cord-270892-ycc3csyh	885	66	in	in	IN
cord-270892-ycc3csyh	885	67	the	the	DT
cord-270892-ycc3csyh	885	68	etiology	etiology	NN
cord-270892-ycc3csyh	885	69	of	of	IN
cord-270892-ycc3csyh	885	70	the	the	DT
cord-270892-ycc3csyh	885	71	common	common	JJ
cord-270892-ycc3csyh	885	72	cold	cold	NN
cord-270892-ycc3csyh	885	73	The	the	DT
cord-270892-ycc3csyh	885	74	seasonality	seasonality	NN
cord-270892-ycc3csyh	885	75	of	of	IN
cord-270892-ycc3csyh	885	76	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	885	77	infections	infection	NNS
cord-270892-ycc3csyh	885	78	and	and	CC
cord-270892-ycc3csyh	885	79	its	-PRON-	PRP$
cord-270892-ycc3csyh	885	80	implications	implication	NNS
cord-270892-ycc3csyh	885	81	for	for	IN
cord-270892-ycc3csyh	885	82	clinical	clinical	JJ
cord-270892-ycc3csyh	885	83	recognition	recognition	NN
cord-270892-ycc3csyh	885	84	Respiratory	respiratory	JJ
cord-270892-ycc3csyh	885	85	pathogens	pathogen	NNS
cord-270892-ycc3csyh	885	86	in	in	IN
cord-270892-ycc3csyh	885	87	children	child	NNS
cord-270892-ycc3csyh	885	88	with	with	IN
cord-270892-ycc3csyh	885	89	and	and	CC
cord-270892-ycc3csyh	885	90	without	without	IN
cord-270892-ycc3csyh	885	91	respiratory	respiratory	JJ
cord-270892-ycc3csyh	885	92	symptoms	symptom	NNS
cord-270892-ycc3csyh	885	93	Virological	virological	JJ
cord-270892-ycc3csyh	885	94	and	and	CC
cord-270892-ycc3csyh	885	95	serological	serological	JJ
cord-270892-ycc3csyh	885	96	analysis	analysis	NN
cord-270892-ycc3csyh	885	97	of	of	IN
cord-270892-ycc3csyh	885	98	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	885	99	infections	infection	NNS
cord-270892-ycc3csyh	885	100	during	during	IN
cord-270892-ycc3csyh	885	101	the	the	DT
cord-270892-ycc3csyh	885	102	first	first	JJ
cord-270892-ycc3csyh	885	103	two	two	CD
cord-270892-ycc3csyh	885	104	years	year	NNS
cord-270892-ycc3csyh	885	105	of	of	IN
cord-270892-ycc3csyh	885	106	life	life	NN
cord-270892-ycc3csyh	885	107	in	in	IN
cord-270892-ycc3csyh	885	108	a	a	DT
cord-270892-ycc3csyh	885	109	cohort	cohort	NN
cord-270892-ycc3csyh	885	110	of	of	IN
cord-270892-ycc3csyh	885	111	children	child	NNS
cord-270892-ycc3csyh	885	112	Novel	Novel	NNP
cord-270892-ycc3csyh	885	113	species	specie	NNS
cord-270892-ycc3csyh	885	114	of	of	IN
cord-270892-ycc3csyh	885	115	human	human	JJ
cord-270892-ycc3csyh	885	116	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	885	117	in	in	IN
cord-270892-ycc3csyh	885	118	acute	acute	JJ
cord-270892-ycc3csyh	885	119	otitis	otitis	NN
cord-270892-ycc3csyh	885	120	media	medium	NNS
cord-270892-ycc3csyh	885	121	Spectrum	Spectrum	NNP
cord-270892-ycc3csyh	885	122	of	of	IN
cord-270892-ycc3csyh	885	123	clinical	clinical	JJ
cord-270892-ycc3csyh	885	124	illness	illness	NN
cord-270892-ycc3csyh	885	125	in	in	IN
cord-270892-ycc3csyh	885	126	hospitalized	hospitalize	VBN
cord-270892-ycc3csyh	885	127	patients	patient	NNS
cord-270892-ycc3csyh	885	128	with	with	IN
cord-270892-ycc3csyh	885	129	'	'	''
cord-270892-ycc3csyh	885	130	'	'	``
cord-270892-ycc3csyh	885	131	common	common	JJ
cord-270892-ycc3csyh	885	132	cold	cold	NN
cord-270892-ycc3csyh	885	133	'	'	''
cord-270892-ycc3csyh	885	134	'	'	''
cord-270892-ycc3csyh	885	135	virus	virus	NN
cord-270892-ycc3csyh	885	136	infections	infection	NNS
cord-270892-ycc3csyh	885	137	Respiratory	respiratory	JJ
cord-270892-ycc3csyh	885	138	viruses	virus	NNS
cord-270892-ycc3csyh	885	139	and	and	CC
cord-270892-ycc3csyh	885	140	severe	severe	JJ
cord-270892-ycc3csyh	885	141	lower	low	JJR
cord-270892-ycc3csyh	885	142	respiratory	respiratory	JJ
cord-270892-ycc3csyh	885	143	tract	tract	NN
cord-270892-ycc3csyh	885	144	complications	complication	NNS
cord-270892-ycc3csyh	885	145	in	in	IN
cord-270892-ycc3csyh	885	146	hospitalized	hospitalize	VBN
cord-270892-ycc3csyh	885	147	patients	patient	NNS
cord-270892-ycc3csyh	885	148	Respiratory	respiratory	JJ
cord-270892-ycc3csyh	885	149	viruses	virus	NNS
cord-270892-ycc3csyh	885	150	in	in	IN
cord-270892-ycc3csyh	885	151	HIV	HIV	NNP
cord-270892-ycc3csyh	885	152	-	-	HYPH
cord-270892-ycc3csyh	885	153	infected	infect	VBN
cord-270892-ycc3csyh	885	154	patients	patient	NNS
cord-270892-ycc3csyh	885	155	with	with	IN
cord-270892-ycc3csyh	885	156	suspected	suspect	VBN
cord-270892-ycc3csyh	885	157	respiratory	respiratory	JJ
cord-270892-ycc3csyh	885	158	opportunistic	opportunistic	JJ
cord-270892-ycc3csyh	885	159	infection	infection	NN
cord-270892-ycc3csyh	886	1	Rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	886	2	infection	infection	NN
cord-270892-ycc3csyh	886	3	preferentially	preferentially	RB
cord-270892-ycc3csyh	886	4	increases	increase	VBZ
cord-270892-ycc3csyh	886	5	lower	low	JJR
cord-270892-ycc3csyh	886	6	airway	airway	NN
cord-270892-ycc3csyh	886	7	responsiveness	responsiveness	NN
cord-270892-ycc3csyh	886	8	in	in	IN
cord-270892-ycc3csyh	886	9	allergic	allergic	JJ
cord-270892-ycc3csyh	886	10	subjects	subject	NNS
cord-270892-ycc3csyh	886	11	Rhinovirus	Rhinovirus	NNP
cord-270892-ycc3csyh	886	12	infections	infection	NNS
cord-270892-ycc3csyh	886	13	in	in	IN
cord-270892-ycc3csyh	886	14	myelosuppressed	myelosuppressed	JJ
cord-270892-ycc3csyh	886	15	adult	adult	NN
cord-270892-ycc3csyh	886	16	blood	blood	NN
cord-270892-ycc3csyh	886	17	and	and	CC
cord-270892-ycc3csyh	886	18	marrow	marrow	NN
cord-270892-ycc3csyh	886	19	transplant	transplant	NN
cord-270892-ycc3csyh	886	20	recipients	recipient	NNS
cord-270892-ycc3csyh	886	21	Rhinovirus	Rhinovirus	NNP
cord-270892-ycc3csyh	886	22	infections	infection	NNS
cord-270892-ycc3csyh	886	23	in	in	IN
cord-270892-ycc3csyh	886	24	hematopoietic	hematopoietic	JJ
cord-270892-ycc3csyh	886	25	stem	stem	NN
cord-270892-ycc3csyh	886	26	cell	cell	NN
cord-270892-ycc3csyh	886	27	transplant	transplant	NN
cord-270892-ycc3csyh	886	28	recipients	recipient	NNS
cord-270892-ycc3csyh	886	29	with	with	IN
cord-270892-ycc3csyh	886	30	pneumonia	pneumonia	NNP
cord-270892-ycc3csyh	886	31	Association	Association	NNP
cord-270892-ycc3csyh	886	32	of	of	IN
cord-270892-ycc3csyh	886	33	respiratory	respiratory	JJ
cord-270892-ycc3csyh	886	34	picornaviruses	picornavirus	NNS
cord-270892-ycc3csyh	886	35	with	with	IN
cord-270892-ycc3csyh	886	36	acute	acute	JJ
cord-270892-ycc3csyh	886	37	bronchiolitis	bronchiolitis	NN
cord-270892-ycc3csyh	886	38	in	in	IN
cord-270892-ycc3csyh	886	39	French	french	JJ
cord-270892-ycc3csyh	886	40	infants	infant	NNS
cord-270892-ycc3csyh	887	1	Chronic	chronic	JJ
cord-270892-ycc3csyh	887	2	rhinoviral	rhinoviral	JJ
cord-270892-ycc3csyh	887	3	infection	infection	NN
cord-270892-ycc3csyh	887	4	in	in	IN
cord-270892-ycc3csyh	887	5	lung	lung	NN
cord-270892-ycc3csyh	887	6	transplant	transplant	NN
cord-270892-ycc3csyh	887	7	recipients	recipient	NNS
cord-270892-ycc3csyh	887	8	Risk	risk	NN
cord-270892-ycc3csyh	887	9	factors	factor	NNS
cord-270892-ycc3csyh	887	10	for	for	IN
cord-270892-ycc3csyh	887	11	asthma	asthma	NN
cord-270892-ycc3csyh	887	12	and	and	CC
cord-270892-ycc3csyh	887	13	atopy	atopy	NN
cord-270892-ycc3csyh	887	14	Interleukin-10	interleukin-10	NN
cord-270892-ycc3csyh	887	15	gene	gene	NN
cord-270892-ycc3csyh	887	16	expression	expression	NN
cord-270892-ycc3csyh	887	17	in	in	IN
cord-270892-ycc3csyh	887	18	acute	acute	JJ
cord-270892-ycc3csyh	887	19	virus	virus	NN
cord-270892-ycc3csyh	887	20	-	-	HYPH
cord-270892-ycc3csyh	887	21	induced	induce	VBN
cord-270892-ycc3csyh	887	22	asthma	asthma	NN
cord-270892-ycc3csyh	887	23	Community	Community	NNP
cord-270892-ycc3csyh	887	24	study	study	NN
cord-270892-ycc3csyh	887	25	of	of	IN
cord-270892-ycc3csyh	887	26	role	role	NN
cord-270892-ycc3csyh	887	27	of	of	IN
cord-270892-ycc3csyh	887	28	viral	viral	JJ
cord-270892-ycc3csyh	887	29	infections	infection	NNS
cord-270892-ycc3csyh	887	30	in	in	IN
cord-270892-ycc3csyh	887	31	exacerbations	exacerbation	NNS
cord-270892-ycc3csyh	887	32	of	of	IN
cord-270892-ycc3csyh	887	33	asthma	asthma	NN
cord-270892-ycc3csyh	887	34	in	in	IN
cord-270892-ycc3csyh	887	35	9	9	CD
cord-270892-ycc3csyh	887	36	-	-	SYM
cord-270892-ycc3csyh	887	37	11	11	CD
cord-270892-ycc3csyh	887	38	year	year	NN
cord-270892-ycc3csyh	887	39	old	old	JJ
cord-270892-ycc3csyh	887	40	children	child	NNS
cord-270892-ycc3csyh	887	41	Asthmatic	asthmatic	JJ
cord-270892-ycc3csyh	887	42	bronchial	bronchial	JJ
cord-270892-ycc3csyh	887	43	epithelial	epithelial	JJ
cord-270892-ycc3csyh	887	44	cells	cell	NNS
cord-270892-ycc3csyh	887	45	have	have	VBP
cord-270892-ycc3csyh	887	46	a	a	DT
cord-270892-ycc3csyh	887	47	deficient	deficient	JJ
cord-270892-ycc3csyh	887	48	innate	innate	JJ
cord-270892-ycc3csyh	887	49	immune	immune	JJ
cord-270892-ycc3csyh	887	50	response	response	NN
cord-270892-ycc3csyh	887	51	to	to	IN
cord-270892-ycc3csyh	887	52	infection	infection	NN
cord-270892-ycc3csyh	887	53	with	with	IN
cord-270892-ycc3csyh	887	54	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	887	55	Viral	viral	JJ
cord-270892-ycc3csyh	887	56	pathogens	pathogen	NNS
cord-270892-ycc3csyh	887	57	in	in	IN
cord-270892-ycc3csyh	887	58	acute	acute	JJ
cord-270892-ycc3csyh	887	59	exacerbations	exacerbation	NNS
cord-270892-ycc3csyh	887	60	of	of	IN
cord-270892-ycc3csyh	887	61	chronic	chronic	JJ
cord-270892-ycc3csyh	887	62	obstructive	obstructive	JJ
cord-270892-ycc3csyh	887	63	pulmonary	pulmonary	JJ
cord-270892-ycc3csyh	887	64	disease	disease	NN
cord-270892-ycc3csyh	887	65	Respiratory	respiratory	JJ
cord-270892-ycc3csyh	887	66	viral	viral	JJ
cord-270892-ycc3csyh	887	67	infection	infection	NN
cord-270892-ycc3csyh	887	68	in	in	IN
cord-270892-ycc3csyh	887	69	exacerbations	exacerbation	NNS
cord-270892-ycc3csyh	887	70	of	of	IN
cord-270892-ycc3csyh	887	71	COPD	COPD	NNP
cord-270892-ycc3csyh	888	1	The	the	DT
cord-270892-ycc3csyh	888	2	role	role	NN
cord-270892-ycc3csyh	888	3	of	of	IN
cord-270892-ycc3csyh	888	4	respiratory	respiratory	JJ
cord-270892-ycc3csyh	888	5	infections	infection	NNS
cord-270892-ycc3csyh	888	6	in	in	IN
cord-270892-ycc3csyh	888	7	chronic	chronic	JJ
cord-270892-ycc3csyh	888	8	obstructive	obstructive	JJ
cord-270892-ycc3csyh	888	9	pulmonary	pulmonary	JJ
cord-270892-ycc3csyh	888	10	disease	disease	NN
cord-270892-ycc3csyh	888	11	Respiratory	respiratory	JJ
cord-270892-ycc3csyh	888	12	viral	viral	JJ
cord-270892-ycc3csyh	888	13	infections	infection	NNS
cord-270892-ycc3csyh	888	14	drive	drive	VBP
cord-270892-ycc3csyh	888	15	chemokine	chemokine	NN
cord-270892-ycc3csyh	888	16	expression	expression	NN
cord-270892-ycc3csyh	888	17	and	and	CC
cord-270892-ycc3csyh	888	18	exacerbate	exacerbate	VB
cord-270892-ycc3csyh	888	19	the	the	DT
cord-270892-ycc3csyh	888	20	asthmatic	asthmatic	JJ
cord-270892-ycc3csyh	888	21	response	response	NN
cord-270892-ycc3csyh	888	22	Respiratory	respiratory	JJ
cord-270892-ycc3csyh	888	23	viruses	virus	NNS
cord-270892-ycc3csyh	888	24	,	,	,
cord-270892-ycc3csyh	888	25	symptoms	symptom	NNS
cord-270892-ycc3csyh	888	26	,	,	,
cord-270892-ycc3csyh	888	27	and	and	CC
cord-270892-ycc3csyh	888	28	inflammatory	inflammatory	JJ
cord-270892-ycc3csyh	888	29	markers	marker	NNS
cord-270892-ycc3csyh	888	30	in	in	IN
cord-270892-ycc3csyh	888	31	acute	acute	JJ
cord-270892-ycc3csyh	888	32	exacerbations	exacerbation	NNS
cord-270892-ycc3csyh	888	33	and	and	CC
cord-270892-ycc3csyh	888	34	stable	stable	JJ
cord-270892-ycc3csyh	888	35	chronic	chronic	JJ
cord-270892-ycc3csyh	888	36	obstructive	obstructive	JJ
cord-270892-ycc3csyh	888	37	pulmonary	pulmonary	JJ
cord-270892-ycc3csyh	888	38	disease	disease	NN
cord-270892-ycc3csyh	888	39	Detection	detection	NN
cord-270892-ycc3csyh	888	40	of	of	IN
cord-270892-ycc3csyh	888	41	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	888	42	in	in	IN
cord-270892-ycc3csyh	888	43	induced	induce	VBN
cord-270892-ycc3csyh	888	44	sputum	sputum	NN
cord-270892-ycc3csyh	888	45	at	at	IN
cord-270892-ycc3csyh	888	46	exacerbation	exacerbation	NN
cord-270892-ycc3csyh	888	47	of	of	IN
cord-270892-ycc3csyh	888	48	chronic	chronic	JJ
cord-270892-ycc3csyh	888	49	obstructive	obstructive	JJ
cord-270892-ycc3csyh	888	50	pulmonary	pulmonary	JJ
cord-270892-ycc3csyh	888	51	disease	disease	NN
cord-270892-ycc3csyh	888	52	Respiratory	respiratory	JJ
cord-270892-ycc3csyh	888	53	syncytial	syncytial	JJ
cord-270892-ycc3csyh	888	54	virus	virus	NN
cord-270892-ycc3csyh	888	55	infection	infection	NN
cord-270892-ycc3csyh	888	56	in	in	IN
cord-270892-ycc3csyh	888	57	infants	infant	NNS
cord-270892-ycc3csyh	888	58	admitted	admit	VBN
cord-270892-ycc3csyh	888	59	to	to	IN
cord-270892-ycc3csyh	888	60	paediatric	paediatric	JJ
cord-270892-ycc3csyh	888	61	intensive	intensive	JJ
cord-270892-ycc3csyh	888	62	care	care	NN
cord-270892-ycc3csyh	888	63	units	unit	NNS
cord-270892-ycc3csyh	888	64	in	in	IN
cord-270892-ycc3csyh	888	65	London	London	NNP
cord-270892-ycc3csyh	888	66	,	,	,
cord-270892-ycc3csyh	888	67	and	and	CC
cord-270892-ycc3csyh	888	68	in	in	IN
cord-270892-ycc3csyh	888	69	their	-PRON-	PRP$
cord-270892-ycc3csyh	888	70	families	family	NNS
cord-270892-ycc3csyh	888	71	Effect	effect	NN
cord-270892-ycc3csyh	888	72	of	of	IN
cord-270892-ycc3csyh	888	73	respiratory	respiratory	JJ
cord-270892-ycc3csyh	888	74	virus	virus	NN
cord-270892-ycc3csyh	888	75	infections	infection	NNS
cord-270892-ycc3csyh	888	76	including	include	VBG
cord-270892-ycc3csyh	888	77	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	888	78	on	on	IN
cord-270892-ycc3csyh	888	79	clinical	clinical	JJ
cord-270892-ycc3csyh	888	80	status	status	NN
cord-270892-ycc3csyh	888	81	in	in	IN
cord-270892-ycc3csyh	888	82	cystic	cystic	JJ
cord-270892-ycc3csyh	888	83	fibrosis	fibrosis	NN
cord-270892-ycc3csyh	889	1	The	the	DT
cord-270892-ycc3csyh	889	2	role	role	NN
cord-270892-ycc3csyh	889	3	of	of	IN
cord-270892-ycc3csyh	889	4	respiratory	respiratory	JJ
cord-270892-ycc3csyh	889	5	viruses	virus	NNS
cord-270892-ycc3csyh	889	6	in	in	IN
cord-270892-ycc3csyh	889	7	cystic	cystic	JJ
cord-270892-ycc3csyh	889	8	fibrosis	fibrosis	NN
cord-270892-ycc3csyh	890	1	Novel	novel	JJ
cord-270892-ycc3csyh	890	2	human	human	JJ
cord-270892-ycc3csyh	890	3	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	890	4	and	and	CC
cord-270892-ycc3csyh	890	5	exacerbation	exacerbation	NN
cord-270892-ycc3csyh	890	6	of	of	IN
cord-270892-ycc3csyh	890	7	asthma	asthma	NN
cord-270892-ycc3csyh	890	8	in	in	IN
cord-270892-ycc3csyh	890	9	children	child	NNS
cord-270892-ycc3csyh	891	1	A	a	DT
cord-270892-ycc3csyh	891	2	novel	novel	JJ
cord-270892-ycc3csyh	891	3	group	group	NN
cord-270892-ycc3csyh	891	4	of	of	IN
cord-270892-ycc3csyh	891	5	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	891	6	is	be	VBZ
cord-270892-ycc3csyh	891	7	associated	associate	VBN
cord-270892-ycc3csyh	891	8	with	with	IN
cord-270892-ycc3csyh	891	9	asthma	asthma	NN
cord-270892-ycc3csyh	891	10	hospitalizations	hospitalization	NNS
cord-270892-ycc3csyh	891	11	Rhinovirus	Rhinovirus	NNP
cord-270892-ycc3csyh	891	12	transmission	transmission	NN
cord-270892-ycc3csyh	891	13	:	:	:
cord-270892-ycc3csyh	891	14	one	one	CD
cord-270892-ycc3csyh	891	15	if	if	IN
cord-270892-ycc3csyh	891	16	by	by	IN
cord-270892-ycc3csyh	891	17	air	air	NN
cord-270892-ycc3csyh	891	18	,	,	,
cord-270892-ycc3csyh	891	19	two	two	CD
cord-270892-ycc3csyh	891	20	if	if	IN
cord-270892-ycc3csyh	891	21	by	by	IN
cord-270892-ycc3csyh	891	22	hand	hand	NN
cord-270892-ycc3csyh	892	1	How	how	WRB
cord-270892-ycc3csyh	892	2	contagious	contagious	JJ
cord-270892-ycc3csyh	892	3	are	be	VBP
cord-270892-ycc3csyh	892	4	common	common	JJ
cord-270892-ycc3csyh	892	5	respiratory	respiratory	JJ
cord-270892-ycc3csyh	892	6	tract	tract	NN
cord-270892-ycc3csyh	892	7	infections	infection	NNS
cord-270892-ycc3csyh	892	8	?	?	.
cord-270892-ycc3csyh	893	1	Environmental	environmental	JJ
cord-270892-ycc3csyh	893	2	contamination	contamination	NN
cord-270892-ycc3csyh	893	3	with	with	IN
cord-270892-ycc3csyh	893	4	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	893	5	and	and	CC
cord-270892-ycc3csyh	893	6	transfer	transfer	VB
cord-270892-ycc3csyh	893	7	to	to	IN
cord-270892-ycc3csyh	893	8	fingers	finger	NNS
cord-270892-ycc3csyh	893	9	of	of	IN
cord-270892-ycc3csyh	893	10	healthy	healthy	JJ
cord-270892-ycc3csyh	893	11	individuals	individual	NNS
cord-270892-ycc3csyh	893	12	by	by	IN
cord-270892-ycc3csyh	893	13	daily	daily	JJ
cord-270892-ycc3csyh	893	14	life	life	NN
cord-270892-ycc3csyh	893	15	activity	activity	NN
cord-270892-ycc3csyh	893	16	Aerosol	Aerosol	NNP
cord-270892-ycc3csyh	893	17	transmission	transmission	NN
cord-270892-ycc3csyh	893	18	of	of	IN
cord-270892-ycc3csyh	893	19	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	893	20	colds	cold	NNS
cord-270892-ycc3csyh	893	21	Hand	hand	NN
cord-270892-ycc3csyh	893	22	-	-	HYPH
cord-270892-ycc3csyh	893	23	to	to	IN
cord-270892-ycc3csyh	893	24	-	-	HYPH
cord-270892-ycc3csyh	893	25	hand	hand	NN
cord-270892-ycc3csyh	893	26	transmission	transmission	NN
cord-270892-ycc3csyh	893	27	of	of	IN
cord-270892-ycc3csyh	893	28	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	893	29	colds	cold	NNS
cord-270892-ycc3csyh	893	30	Transmission	Transmission	NNP
cord-270892-ycc3csyh	893	31	of	of	IN
cord-270892-ycc3csyh	893	32	experimental	experimental	JJ
cord-270892-ycc3csyh	893	33	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	893	34	infection	infection	NN
cord-270892-ycc3csyh	893	35	by	by	IN
cord-270892-ycc3csyh	893	36	contaminated	contaminated	JJ
cord-270892-ycc3csyh	893	37	surfaces	surface	NNS
cord-270892-ycc3csyh	893	38	Interruption	interruption	NN
cord-270892-ycc3csyh	893	39	of	of	IN
cord-270892-ycc3csyh	893	40	experimental	experimental	JJ
cord-270892-ycc3csyh	893	41	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	893	42	transmission	transmission	NN
cord-270892-ycc3csyh	893	43	Virucidal	virucidal	JJ
cord-270892-ycc3csyh	893	44	activity	activity	NN
cord-270892-ycc3csyh	893	45	and	and	CC
cord-270892-ycc3csyh	893	46	cytotoxicity	cytotoxicity	NN
cord-270892-ycc3csyh	893	47	of	of	IN
cord-270892-ycc3csyh	893	48	the	the	DT
cord-270892-ycc3csyh	893	49	liposomal	liposomal	JJ
cord-270892-ycc3csyh	893	50	formulation	formulation	NN
cord-270892-ycc3csyh	893	51	of	of	IN
cord-270892-ycc3csyh	893	52	povidone	povidone	NN
cord-270892-ycc3csyh	893	53	-	-	HYPH
cord-270892-ycc3csyh	893	54	iodine	iodine	NN
cord-270892-ycc3csyh	893	55	Virucidal	virucidal	JJ
cord-270892-ycc3csyh	893	56	hand	hand	NN
cord-270892-ycc3csyh	893	57	treatments	treatment	NNS
cord-270892-ycc3csyh	893	58	for	for	IN
cord-270892-ycc3csyh	893	59	prevention	prevention	NN
cord-270892-ycc3csyh	893	60	of	of	IN
cord-270892-ycc3csyh	893	61	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	893	62	infection	infection	NN
cord-270892-ycc3csyh	893	63	Localization	Localization	NNP
cord-270892-ycc3csyh	893	64	of	of	IN
cord-270892-ycc3csyh	893	65	human	human	JJ
cord-270892-ycc3csyh	893	66	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	893	67	replication	replication	NN
cord-270892-ycc3csyh	893	68	in	in	IN
cord-270892-ycc3csyh	893	69	the	the	DT
cord-270892-ycc3csyh	893	70	upper	upper	JJ
cord-270892-ycc3csyh	893	71	respiratory	respiratory	JJ
cord-270892-ycc3csyh	893	72	tract	tract	NN
cord-270892-ycc3csyh	893	73	by	by	IN
cord-270892-ycc3csyh	893	74	in	in	IN
cord-270892-ycc3csyh	893	75	situ	situ	JJ
cord-270892-ycc3csyh	893	76	hybridization	hybridization	NN
cord-270892-ycc3csyh	893	77	Experimental	experimental	JJ
cord-270892-ycc3csyh	893	78	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	893	79	infection	infection	NN
cord-270892-ycc3csyh	893	80	in	in	IN
cord-270892-ycc3csyh	893	81	volunteers	volunteer	NNS
cord-270892-ycc3csyh	893	82	Detection	Detection	NNP
cord-270892-ycc3csyh	893	83	of	of	IN
cord-270892-ycc3csyh	893	84	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	893	85	RNA	RNA	NNP
cord-270892-ycc3csyh	893	86	in	in	IN
cord-270892-ycc3csyh	893	87	lower	low	JJR
cord-270892-ycc3csyh	893	88	airway	airway	NN
cord-270892-ycc3csyh	893	89	cells	cell	NNS
cord-270892-ycc3csyh	893	90	during	during	IN
cord-270892-ycc3csyh	893	91	experimentally	experimentally	RB
cord-270892-ycc3csyh	893	92	induced	induce	VBN
cord-270892-ycc3csyh	893	93	infection	infection	NN
cord-270892-ycc3csyh	893	94	Relationship	relationship	NN
cord-270892-ycc3csyh	893	95	of	of	IN
cord-270892-ycc3csyh	893	96	upper	upper	JJ
cord-270892-ycc3csyh	893	97	and	and	CC
cord-270892-ycc3csyh	893	98	lower	low	JJR
cord-270892-ycc3csyh	893	99	airway	airway	NN
cord-270892-ycc3csyh	893	100	cytokines	cytokine	NNS
cord-270892-ycc3csyh	893	101	to	to	TO
cord-270892-ycc3csyh	893	102	outcome	outcome	VB
cord-270892-ycc3csyh	893	103	of	of	IN
cord-270892-ycc3csyh	893	104	experimental	experimental	JJ
cord-270892-ycc3csyh	893	105	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	893	106	infection	infection	NN
cord-270892-ycc3csyh	893	107	Histopathologic	Histopathologic	NNP
cord-270892-ycc3csyh	893	108	examination	examination	NN
cord-270892-ycc3csyh	893	109	and	and	CC
cord-270892-ycc3csyh	893	110	enumeration	enumeration	NN
cord-270892-ycc3csyh	893	111	of	of	IN
cord-270892-ycc3csyh	893	112	polymorphonuclear	polymorphonuclear	JJ
cord-270892-ycc3csyh	893	113	leukocytes	leukocyte	NNS
cord-270892-ycc3csyh	893	114	in	in	IN
cord-270892-ycc3csyh	893	115	the	the	DT
cord-270892-ycc3csyh	893	116	nasal	nasal	NN
cord-270892-ycc3csyh	893	117	mucosa	mucosa	JJ
cord-270892-ycc3csyh	893	118	during	during	IN
cord-270892-ycc3csyh	893	119	experimental	experimental	JJ
cord-270892-ycc3csyh	893	120	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	893	121	colds	cold	NNS
cord-270892-ycc3csyh	893	122	Sites	site	NNS
cord-270892-ycc3csyh	893	123	of	of	IN
cord-270892-ycc3csyh	893	124	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	893	125	recovery	recovery	NN
cord-270892-ycc3csyh	893	126	after	after	IN
cord-270892-ycc3csyh	893	127	point	point	NN
cord-270892-ycc3csyh	893	128	inoculation	inoculation	NN
cord-270892-ycc3csyh	893	129	of	of	IN
cord-270892-ycc3csyh	893	130	the	the	DT
cord-270892-ycc3csyh	893	131	upper	upper	JJ
cord-270892-ycc3csyh	893	132	airway	airway	NN
cord-270892-ycc3csyh	893	133	Incubation	Incubation	NNP
cord-270892-ycc3csyh	893	134	periods	period	NNS
cord-270892-ycc3csyh	893	135	of	of	IN
cord-270892-ycc3csyh	893	136	experimental	experimental	JJ
cord-270892-ycc3csyh	893	137	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	893	138	infection	infection	NN
cord-270892-ycc3csyh	893	139	and	and	CC
cord-270892-ycc3csyh	893	140	illness	illness	NN
cord-270892-ycc3csyh	893	141	Quantitative	quantitative	JJ
cord-270892-ycc3csyh	893	142	and	and	CC
cord-270892-ycc3csyh	893	143	qualitative	qualitative	JJ
cord-270892-ycc3csyh	893	144	analysis	analysis	NN
cord-270892-ycc3csyh	893	145	of	of	IN
cord-270892-ycc3csyh	893	146	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	893	147	infection	infection	NN
cord-270892-ycc3csyh	893	148	in	in	IN
cord-270892-ycc3csyh	893	149	bronchial	bronchial	JJ
cord-270892-ycc3csyh	893	150	tissues	tissue	NNS
cord-270892-ycc3csyh	894	1	Rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	894	2	infect	infect	VBP
cord-270892-ycc3csyh	894	3	the	the	DT
cord-270892-ycc3csyh	894	4	lower	low	JJR
cord-270892-ycc3csyh	894	5	airways	airway	NNS
cord-270892-ycc3csyh	894	6	Incidence	incidence	NN
cord-270892-ycc3csyh	894	7	and	and	CC
cord-270892-ycc3csyh	894	8	characteristics	characteristic	NNS
cord-270892-ycc3csyh	894	9	of	of	IN
cord-270892-ycc3csyh	894	10	viral	viral	JJ
cord-270892-ycc3csyh	894	11	community	community	NN
cord-270892-ycc3csyh	894	12	-	-	HYPH
cord-270892-ycc3csyh	894	13	acquired	acquire	VBN
cord-270892-ycc3csyh	894	14	pneumonia	pneumonia	NN
cord-270892-ycc3csyh	894	15	in	in	IN
cord-270892-ycc3csyh	894	16	adults	adult	NNS
cord-270892-ycc3csyh	894	17	Etiology	etiology	NN
cord-270892-ycc3csyh	894	18	of	of	IN
cord-270892-ycc3csyh	894	19	community	community	NN
cord-270892-ycc3csyh	894	20	-	-	HYPH
cord-270892-ycc3csyh	894	21	acquired	acquire	VBN
cord-270892-ycc3csyh	894	22	pneumonia	pneumonia	NN
cord-270892-ycc3csyh	894	23	in	in	IN
cord-270892-ycc3csyh	894	24	254	254	CD
cord-270892-ycc3csyh	894	25	hospitalized	hospitalize	VBN
cord-270892-ycc3csyh	894	26	children	child	NNS
cord-270892-ycc3csyh	894	27	Improved	improve	VBD
cord-270892-ycc3csyh	894	28	diagnosis	diagnosis	NN
cord-270892-ycc3csyh	894	29	of	of	IN
cord-270892-ycc3csyh	894	30	the	the	DT
cord-270892-ycc3csyh	894	31	etiology	etiology	NN
cord-270892-ycc3csyh	894	32	of	of	IN
cord-270892-ycc3csyh	894	33	community	community	NN
cord-270892-ycc3csyh	894	34	-	-	HYPH
cord-270892-ycc3csyh	894	35	acquired	acquire	VBN
cord-270892-ycc3csyh	894	36	pneumonia	pneumonia	NN
cord-270892-ycc3csyh	894	37	with	with	IN
cord-270892-ycc3csyh	894	38	real	real	JJ
cord-270892-ycc3csyh	894	39	-	-	HYPH
cord-270892-ycc3csyh	894	40	time	time	NN
cord-270892-ycc3csyh	894	41	polymerase	polymerase	NN
cord-270892-ycc3csyh	894	42	chain	chain	NN
cord-270892-ycc3csyh	894	43	reaction	reaction	NN
cord-270892-ycc3csyh	894	44	Etiology	etiology	NN
cord-270892-ycc3csyh	894	45	of	of	IN
cord-270892-ycc3csyh	894	46	community	community	NN
cord-270892-ycc3csyh	894	47	-	-	HYPH
cord-270892-ycc3csyh	894	48	acquired	acquire	VBN
cord-270892-ycc3csyh	894	49	pneumonia	pneumonia	NN
cord-270892-ycc3csyh	894	50	in	in	IN
cord-270892-ycc3csyh	894	51	hospitalized	hospitalize	VBN
cord-270892-ycc3csyh	894	52	school	school	NN
cord-270892-ycc3csyh	894	53	-	-	HYPH
cord-270892-ycc3csyh	894	54	age	age	NN
cord-270892-ycc3csyh	894	55	children	child	NNS
cord-270892-ycc3csyh	894	56	:	:	:
cord-270892-ycc3csyh	894	57	Evidence	evidence	NN
cord-270892-ycc3csyh	894	58	for	for	IN
cord-270892-ycc3csyh	894	59	high	high	JJ
cord-270892-ycc3csyh	894	60	prevalence	prevalence	NN
cord-270892-ycc3csyh	894	61	of	of	IN
cord-270892-ycc3csyh	894	62	viral	viral	JJ
cord-270892-ycc3csyh	894	63	infections	infection	NNS
cord-270892-ycc3csyh	894	64	Association	Association	NNP
cord-270892-ycc3csyh	894	65	between	between	IN
cord-270892-ycc3csyh	894	66	interleukin-8	interleukin-8	NNP
cord-270892-ycc3csyh	894	67	concentration	concentration	NN
cord-270892-ycc3csyh	894	68	in	in	IN
cord-270892-ycc3csyh	894	69	nasal	nasal	NN
cord-270892-ycc3csyh	894	70	secretions	secretion	NNS
cord-270892-ycc3csyh	894	71	and	and	CC
cord-270892-ycc3csyh	894	72	severity	severity	NN
cord-270892-ycc3csyh	894	73	of	of	IN
cord-270892-ycc3csyh	894	74	symptoms	symptom	NNS
cord-270892-ycc3csyh	894	75	of	of	IN
cord-270892-ycc3csyh	894	76	experimental	experimental	JJ
cord-270892-ycc3csyh	894	77	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	894	78	colds	cold	NNS
cord-270892-ycc3csyh	894	79	Symptom	symptom	NN
cord-270892-ycc3csyh	894	80	profile	profile	NN
cord-270892-ycc3csyh	894	81	of	of	IN
cord-270892-ycc3csyh	894	82	common	common	JJ
cord-270892-ycc3csyh	894	83	colds	cold	NNS
cord-270892-ycc3csyh	894	84	in	in	IN
cord-270892-ycc3csyh	894	85	schoolaged	schoolaged	JJ
cord-270892-ycc3csyh	894	86	children	child	NNS
cord-270892-ycc3csyh	895	1	The	the	DT
cord-270892-ycc3csyh	895	2	microbial	microbial	JJ
cord-270892-ycc3csyh	895	3	etiology	etiology	NN
cord-270892-ycc3csyh	895	4	and	and	CC
cord-270892-ycc3csyh	895	5	antimicrobial	antimicrobial	JJ
cord-270892-ycc3csyh	895	6	therapy	therapy	NN
cord-270892-ycc3csyh	895	7	of	of	IN
cord-270892-ycc3csyh	895	8	adults	adult	NNS
cord-270892-ycc3csyh	895	9	with	with	IN
cord-270892-ycc3csyh	895	10	acute	acute	JJ
cord-270892-ycc3csyh	895	11	community	community	NN
cord-270892-ycc3csyh	895	12	-	-	HYPH
cord-270892-ycc3csyh	895	13	acquired	acquire	VBN
cord-270892-ycc3csyh	895	14	sinusitis	sinusitis	NN
cord-270892-ycc3csyh	895	15	:	:	:
cord-270892-ycc3csyh	895	16	A	a	DT
cord-270892-ycc3csyh	895	17	fifteen	fifteen	CD
cord-270892-ycc3csyh	895	18	-	-	HYPH
cord-270892-ycc3csyh	895	19	year	year	NN
cord-270892-ycc3csyh	895	20	experience	experience	NN
cord-270892-ycc3csyh	895	21	at	at	IN
cord-270892-ycc3csyh	895	22	the	the	DT
cord-270892-ycc3csyh	895	23	University	University	NNP
cord-270892-ycc3csyh	895	24	of	of	IN
cord-270892-ycc3csyh	895	25	Virginia	Virginia	NNP
cord-270892-ycc3csyh	895	26	and	and	CC
cord-270892-ycc3csyh	895	27	review	review	NN
cord-270892-ycc3csyh	895	28	of	of	IN
cord-270892-ycc3csyh	895	29	other	other	JJ
cord-270892-ycc3csyh	895	30	selected	select	VBN
cord-270892-ycc3csyh	895	31	studies	study	NNS
cord-270892-ycc3csyh	895	32	Bacterial	bacterial	JJ
cord-270892-ycc3csyh	895	33	coinfections	coinfection	NNS
cord-270892-ycc3csyh	895	34	in	in	IN
cord-270892-ycc3csyh	895	35	children	child	NNS
cord-270892-ycc3csyh	895	36	with	with	IN
cord-270892-ycc3csyh	895	37	viral	viral	JJ
cord-270892-ycc3csyh	895	38	wheezing	wheeze	VBG
cord-270892-ycc3csyh	895	39	Amplified	amplify	VBN
cord-270892-ycc3csyh	895	40	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	895	41	colds	cold	NNS
cord-270892-ycc3csyh	895	42	in	in	IN
cord-270892-ycc3csyh	895	43	atopic	atopic	JJ
cord-270892-ycc3csyh	895	44	subjects	subject	NNS
cord-270892-ycc3csyh	895	45	Experimental	experimental	JJ
cord-270892-ycc3csyh	895	46	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	895	47	16	16	CD
cord-270892-ycc3csyh	895	48	infection	infection	NN
cord-270892-ycc3csyh	895	49	potentiates	potentiate	VBZ
cord-270892-ycc3csyh	895	50	histamine	histamine	NN
cord-270892-ycc3csyh	895	51	release	release	NN
cord-270892-ycc3csyh	895	52	after	after	IN
cord-270892-ycc3csyh	895	53	antigen	antigen	NN
cord-270892-ycc3csyh	895	54	bronchoprovocation	bronchoprovocation	NN
cord-270892-ycc3csyh	895	55	in	in	IN
cord-270892-ycc3csyh	895	56	allergic	allergic	JJ
cord-270892-ycc3csyh	895	57	subjects	subject	NNS
cord-270892-ycc3csyh	896	1	Lower	low	JJR
cord-270892-ycc3csyh	896	2	airways	airways	NN
cord-270892-ycc3csyh	896	3	inflammation	inflammation	NN
cord-270892-ycc3csyh	896	4	during	during	IN
cord-270892-ycc3csyh	896	5	rhinovirus	rhinovirus	JJ
cord-270892-ycc3csyh	896	6	colds	cold	NNS
cord-270892-ycc3csyh	896	7	in	in	IN
cord-270892-ycc3csyh	896	8	normal	normal	JJ
cord-270892-ycc3csyh	896	9	and	and	CC
cord-270892-ycc3csyh	896	10	in	in	IN
cord-270892-ycc3csyh	896	11	asthmatic	asthmatic	JJ
cord-270892-ycc3csyh	896	12	subjects	subject	NNS
cord-270892-ycc3csyh	897	1	The	the	DT
cord-270892-ycc3csyh	897	2	effects	effect	NNS
cord-270892-ycc3csyh	897	3	of	of	IN
cord-270892-ycc3csyh	897	4	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	897	5	infections	infection	NNS
cord-270892-ycc3csyh	897	6	on	on	IN
cord-270892-ycc3csyh	897	7	allergic	allergic	JJ
cord-270892-ycc3csyh	897	8	airway	airway	NN
cord-270892-ycc3csyh	897	9	responses	response	NNS
cord-270892-ycc3csyh	897	10	Rhinovirus	Rhinovirus	NNP
cord-270892-ycc3csyh	897	11	upper	upper	JJ
cord-270892-ycc3csyh	897	12	respiratory	respiratory	JJ
cord-270892-ycc3csyh	897	13	infection	infection	NN
cord-270892-ycc3csyh	897	14	increases	increase	VBZ
cord-270892-ycc3csyh	897	15	airway	airway	NN
cord-270892-ycc3csyh	897	16	hyperreactivity	hyperreactivity	NN
cord-270892-ycc3csyh	897	17	and	and	CC
cord-270892-ycc3csyh	897	18	late	late	JJ
cord-270892-ycc3csyh	897	19	asthmatic	asthmatic	JJ
cord-270892-ycc3csyh	897	20	reactions	reaction	NNS
cord-270892-ycc3csyh	898	1	An	an	DT
cord-270892-ycc3csyh	898	2	experimental	experimental	JJ
cord-270892-ycc3csyh	898	3	model	model	NN
cord-270892-ycc3csyh	898	4	of	of	IN
cord-270892-ycc3csyh	898	5	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	898	6	induced	induce	VBN
cord-270892-ycc3csyh	898	7	chronic	chronic	JJ
cord-270892-ycc3csyh	898	8	obstructive	obstructive	JJ
cord-270892-ycc3csyh	898	9	pulmonary	pulmonary	JJ
cord-270892-ycc3csyh	898	10	disease	disease	NN
cord-270892-ycc3csyh	898	11	exacerbations	exacerbation	NNS
cord-270892-ycc3csyh	898	12	:	:	:
cord-270892-ycc3csyh	899	1	A	a	DT
cord-270892-ycc3csyh	899	2	pilot	pilot	NN
cord-270892-ycc3csyh	899	3	study	study	NN
cord-270892-ycc3csyh	899	4	Rhinovirus	Rhinovirus	NNP
cord-270892-ycc3csyh	899	5	-	-	HYPH
cord-270892-ycc3csyh	899	6	induced	induce	VBN
cord-270892-ycc3csyh	899	7	lower	low	JJR
cord-270892-ycc3csyh	899	8	respiratory	respiratory	JJ
cord-270892-ycc3csyh	899	9	illness	illness	NN
cord-270892-ycc3csyh	899	10	is	be	VBZ
cord-270892-ycc3csyh	899	11	increased	increase	VBN
cord-270892-ycc3csyh	899	12	in	in	IN
cord-270892-ycc3csyh	899	13	asthma	asthma	NN
cord-270892-ycc3csyh	899	14	and	and	CC
cord-270892-ycc3csyh	899	15	related	relate	VBN
cord-270892-ycc3csyh	899	16	to	to	IN
cord-270892-ycc3csyh	899	17	virus	virus	NN
cord-270892-ycc3csyh	899	18	load	load	NN
cord-270892-ycc3csyh	899	19	and	and	CC
cord-270892-ycc3csyh	899	20	Th1/2	th1/2	NN
cord-270892-ycc3csyh	899	21	cytokine	cytokine	NN
cord-270892-ycc3csyh	899	22	and	and	CC
cord-270892-ycc3csyh	899	23	IL-10	IL-10	NNP
cord-270892-ycc3csyh	899	24	production	production	NN
cord-270892-ycc3csyh	900	1	The	the	DT
cord-270892-ycc3csyh	900	2	economic	economic	JJ
cord-270892-ycc3csyh	900	3	burden	burden	NN
cord-270892-ycc3csyh	900	4	of	of	IN
cord-270892-ycc3csyh	900	5	non	non	JJ
cord-270892-ycc3csyh	900	6	-	-	JJ
cord-270892-ycc3csyh	900	7	influenzarelated	influenzarelated	JJ
cord-270892-ycc3csyh	900	8	viral	viral	JJ
cord-270892-ycc3csyh	900	9	respiratory	respiratory	JJ
cord-270892-ycc3csyh	900	10	tract	tract	NN
cord-270892-ycc3csyh	900	11	infection	infection	NN
cord-270892-ycc3csyh	900	12	in	in	IN
cord-270892-ycc3csyh	900	13	the	the	DT
cord-270892-ycc3csyh	900	14	United	United	NNP
cord-270892-ycc3csyh	900	15	States	States	NNP
cord-270892-ycc3csyh	900	16	Rhinovirus	Rhinovirus	NNP
cord-270892-ycc3csyh	900	17	chemotherapy	chemotherapy	NN
cord-270892-ycc3csyh	900	18	Excessive	excessive	JJ
cord-270892-ycc3csyh	900	19	antibiotic	antibiotic	JJ
cord-270892-ycc3csyh	900	20	use	use	NN
cord-270892-ycc3csyh	900	21	for	for	IN
cord-270892-ycc3csyh	900	22	acute	acute	JJ
cord-270892-ycc3csyh	900	23	respiratory	respiratory	JJ
cord-270892-ycc3csyh	900	24	infections	infection	NNS
cord-270892-ycc3csyh	900	25	in	in	IN
cord-270892-ycc3csyh	900	26	the	the	DT
cord-270892-ycc3csyh	900	27	United	United	NNP
cord-270892-ycc3csyh	900	28	States	States	NNP
cord-270892-ycc3csyh	900	29	Influenza	Influenza	NNP
cord-270892-ycc3csyh	900	30	virus	virus	NN
cord-270892-ycc3csyh	900	31	and	and	CC
cord-270892-ycc3csyh	900	32	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	900	33	-	-	HYPH
cord-270892-ycc3csyh	900	34	related	relate	VBN
cord-270892-ycc3csyh	900	35	otitis	otitis	NN
cord-270892-ycc3csyh	900	36	media	medium	NNS
cord-270892-ycc3csyh	900	37	:	:	:
cord-270892-ycc3csyh	900	38	Potential	potential	NN
cord-270892-ycc3csyh	900	39	for	for	IN
cord-270892-ycc3csyh	900	40	antiviral	antiviral	JJ
cord-270892-ycc3csyh	900	41	intervention	intervention	NN
cord-270892-ycc3csyh	901	1	The	the	DT
cord-270892-ycc3csyh	901	2	viruses	virus	NNS
cord-270892-ycc3csyh	901	3	and	and	CC
cord-270892-ycc3csyh	901	4	their	-PRON-	PRP$
cord-270892-ycc3csyh	901	5	replication	replication	NN
cord-270892-ycc3csyh	901	6	Analysis	analysis	NN
cord-270892-ycc3csyh	901	7	of	of	IN
cord-270892-ycc3csyh	901	8	the	the	DT
cord-270892-ycc3csyh	901	9	structure	structure	NN
cord-270892-ycc3csyh	901	10	of	of	IN
cord-270892-ycc3csyh	901	11	a	a	DT
cord-270892-ycc3csyh	901	12	common	common	JJ
cord-270892-ycc3csyh	901	13	cold	cold	JJ
cord-270892-ycc3csyh	901	14	virus	virus	NN
cord-270892-ycc3csyh	901	15	,	,	,
cord-270892-ycc3csyh	901	16	human	human	JJ
cord-270892-ycc3csyh	901	17	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	901	18	14	14	CD
cord-270892-ycc3csyh	901	19	,	,	,
cord-270892-ycc3csyh	901	20	refined	refine	VBN
cord-270892-ycc3csyh	901	21	at	at	IN
cord-270892-ycc3csyh	901	22	a	a	DT
cord-270892-ycc3csyh	901	23	resolution	resolution	NN
cord-270892-ycc3csyh	901	24	of	of	IN
cord-270892-ycc3csyh	901	25	3.0	3.0	CD
cord-270892-ycc3csyh	901	26	A	a	NN
cord-270892-ycc3csyh	902	1	The	the	DT
cord-270892-ycc3csyh	902	2	refined	refined	JJ
cord-270892-ycc3csyh	902	3	structure	structure	NN
cord-270892-ycc3csyh	902	4	of	of	IN
cord-270892-ycc3csyh	902	5	human	human	JJ
cord-270892-ycc3csyh	902	6	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	902	7	16	16	CD
cord-270892-ycc3csyh	902	8	at	at	IN
cord-270892-ycc3csyh	902	9	2.15	2.15	CD
cord-270892-ycc3csyh	902	10	A	a	DT
cord-270892-ycc3csyh	902	11	resolution	resolution	NN
cord-270892-ycc3csyh	902	12	:	:	:
cord-270892-ycc3csyh	902	13	Implications	implication	NNS
cord-270892-ycc3csyh	902	14	for	for	IN
cord-270892-ycc3csyh	902	15	the	the	DT
cord-270892-ycc3csyh	902	16	viral	viral	JJ
cord-270892-ycc3csyh	902	17	life	life	NN
cord-270892-ycc3csyh	902	18	cycle	cycle	NN
cord-270892-ycc3csyh	902	19	Crystal	Crystal	NNP
cord-270892-ycc3csyh	902	20	structure	structure	NN
cord-270892-ycc3csyh	902	21	of	of	IN
cord-270892-ycc3csyh	902	22	human	human	JJ
cord-270892-ycc3csyh	902	23	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	902	24	serotype	serotype	NN
cord-270892-ycc3csyh	902	25	1A	1A	NNP
cord-270892-ycc3csyh	902	26	(	(	-LRB-
cord-270892-ycc3csyh	902	27	HRV1A	HRV1A	NNP
cord-270892-ycc3csyh	902	28	)	)	-RRB-
cord-270892-ycc3csyh	903	1	The	the	DT
cord-270892-ycc3csyh	903	2	structure	structure	NN
cord-270892-ycc3csyh	903	3	of	of	IN
cord-270892-ycc3csyh	903	4	human	human	JJ
cord-270892-ycc3csyh	903	5	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	903	6	16	16	CD
cord-270892-ycc3csyh	903	7	Structure	Structure	NNP
cord-270892-ycc3csyh	903	8	of	of	IN
cord-270892-ycc3csyh	903	9	a	a	DT
cord-270892-ycc3csyh	903	10	human	human	JJ
cord-270892-ycc3csyh	903	11	common	common	JJ
cord-270892-ycc3csyh	903	12	cold	cold	JJ
cord-270892-ycc3csyh	903	13	virus	virus	NN
cord-270892-ycc3csyh	903	14	and	and	CC
cord-270892-ycc3csyh	903	15	functional	functional	JJ
cord-270892-ycc3csyh	903	16	relationship	relationship	NN
cord-270892-ycc3csyh	903	17	to	to	IN
cord-270892-ycc3csyh	903	18	other	other	JJ
cord-270892-ycc3csyh	903	19	picornaviruses	picornaviruses	NNP
cord-270892-ycc3csyh	903	20	Structure	Structure	NNP
cord-270892-ycc3csyh	903	21	of	of	IN
cord-270892-ycc3csyh	903	22	human	human	JJ
cord-270892-ycc3csyh	903	23	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	903	24	serotype	serotype	NN
cord-270892-ycc3csyh	903	25	2	2	CD
cord-270892-ycc3csyh	903	26	(	(	-LRB-
cord-270892-ycc3csyh	903	27	HRV2	HRV2	NNP
cord-270892-ycc3csyh	903	28	)	)	-RRB-
cord-270892-ycc3csyh	903	29	Human	human	JJ
cord-270892-ycc3csyh	903	30	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	903	31	3	3	CD
cord-270892-ycc3csyh	903	32	at	at	IN
cord-270892-ycc3csyh	903	33	3.0	3.0	CD
cord-270892-ycc3csyh	903	34	A	a	DT
cord-270892-ycc3csyh	903	35	resolution	resolution	NN
cord-270892-ycc3csyh	903	36	The	the	DT
cord-270892-ycc3csyh	903	37	canyon	canyon	NN
cord-270892-ycc3csyh	903	38	hypothesis	hypothesis	NN
cord-270892-ycc3csyh	903	39	Viral	viral	JJ
cord-270892-ycc3csyh	903	40	cell	cell	NN
cord-270892-ycc3csyh	903	41	recognition	recognition	NN
cord-270892-ycc3csyh	903	42	and	and	CC
cord-270892-ycc3csyh	903	43	entry	entry	NN
cord-270892-ycc3csyh	903	44	Crystallographic	Crystallographic	NNP
cord-270892-ycc3csyh	903	45	and	and	CC
cord-270892-ycc3csyh	904	1	cryo	cryo	NNP
cord-270892-ycc3csyh	904	2	EM	EM	NNP
cord-270892-ycc3csyh	904	3	analysis	analysis	NN
cord-270892-ycc3csyh	904	4	of	of	IN
cord-270892-ycc3csyh	904	5	virion	virion	NN
cord-270892-ycc3csyh	904	6	-	-	HYPH
cord-270892-ycc3csyh	904	7	receptor	receptor	NN
cord-270892-ycc3csyh	904	8	interactions	interaction	NNS
cord-270892-ycc3csyh	905	1	A	a	DT
cord-270892-ycc3csyh	905	2	cell	cell	NN
cord-270892-ycc3csyh	905	3	adhesion	adhesion	NN
cord-270892-ycc3csyh	905	4	molecule	molecule	NN
cord-270892-ycc3csyh	905	5	,	,	,
cord-270892-ycc3csyh	905	6	ICAM-1	ICAM-1	NNP
cord-270892-ycc3csyh	905	7	,	,	,
cord-270892-ycc3csyh	905	8	is	be	VBZ
cord-270892-ycc3csyh	905	9	the	the	DT
cord-270892-ycc3csyh	905	10	major	major	JJ
cord-270892-ycc3csyh	905	11	surface	surface	NN
cord-270892-ycc3csyh	905	12	receptor	receptor	NN
cord-270892-ycc3csyh	905	13	for	for	IN
cord-270892-ycc3csyh	905	14	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	906	1	The	the	DT
cord-270892-ycc3csyh	906	2	minor	minor	JJ
cord-270892-ycc3csyh	906	3	receptor	receptor	NN
cord-270892-ycc3csyh	906	4	group	group	NN
cord-270892-ycc3csyh	906	5	of	of	IN
cord-270892-ycc3csyh	906	6	human	human	JJ
cord-270892-ycc3csyh	906	7	rhinovirus	rhinovirus	NNP
cord-270892-ycc3csyh	906	8	(	(	-LRB-
cord-270892-ycc3csyh	906	9	HRV	HRV	NNP
cord-270892-ycc3csyh	906	10	)	)	-RRB-
cord-270892-ycc3csyh	906	11	includes	include	VBZ
cord-270892-ycc3csyh	906	12	HRV23	HRV23	NNP
cord-270892-ycc3csyh	906	13	and	and	CC
cord-270892-ycc3csyh	906	14	HRV25	HRV25	NNP
cord-270892-ycc3csyh	906	15	,	,	,
cord-270892-ycc3csyh	906	16	but	but	CC
cord-270892-ycc3csyh	906	17	the	the	DT
cord-270892-ycc3csyh	906	18	presence	presence	NN
cord-270892-ycc3csyh	906	19	of	of	IN
cord-270892-ycc3csyh	906	20	a	a	DT
cord-270892-ycc3csyh	906	21	lysine	lysine	NN
cord-270892-ycc3csyh	906	22	in	in	IN
cord-270892-ycc3csyh	906	23	the	the	DT
cord-270892-ycc3csyh	906	24	VP1	vp1	NN
cord-270892-ycc3csyh	906	25	HI	HI	NNP
cord-270892-ycc3csyh	906	26	loop	loop	NN
cord-270892-ycc3csyh	906	27	is	be	VBZ
cord-270892-ycc3csyh	906	28	not	not	RB
cord-270892-ycc3csyh	906	29	sufficient	sufficient	JJ
cord-270892-ycc3csyh	906	30	for	for	IN
cord-270892-ycc3csyh	906	31	receptor	receptor	NN
cord-270892-ycc3csyh	906	32	binding	bind	VBG
cord-270892-ycc3csyh	906	33	Members	member	NNS
cord-270892-ycc3csyh	906	34	of	of	IN
cord-270892-ycc3csyh	906	35	the	the	DT
cord-270892-ycc3csyh	906	36	low	low	JJ
cord-270892-ycc3csyh	906	37	density	density	NN
cord-270892-ycc3csyh	906	38	lipoprotein	lipoprotein	NN
cord-270892-ycc3csyh	906	39	receptor	receptor	NN
cord-270892-ycc3csyh	906	40	family	family	NN
cord-270892-ycc3csyh	906	41	mediate	mediate	VB
cord-270892-ycc3csyh	906	42	cell	cell	NN
cord-270892-ycc3csyh	906	43	entry	entry	NN
cord-270892-ycc3csyh	906	44	of	of	IN
cord-270892-ycc3csyh	906	45	a	a	DT
cord-270892-ycc3csyh	906	46	minor	minor	JJ
cord-270892-ycc3csyh	906	47	-	-	HYPH
cord-270892-ycc3csyh	906	48	group	group	NN
cord-270892-ycc3csyh	906	49	common	common	JJ
cord-270892-ycc3csyh	906	50	cold	cold	JJ
cord-270892-ycc3csyh	906	51	virus	virus	NN
cord-270892-ycc3csyh	906	52	Multiple	multiple	JJ
cord-270892-ycc3csyh	906	53	receptors	receptor	NNS
cord-270892-ycc3csyh	906	54	involved	involve	VBN
cord-270892-ycc3csyh	906	55	in	in	IN
cord-270892-ycc3csyh	906	56	human	human	JJ
cord-270892-ycc3csyh	906	57	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	906	58	attachment	attachment	NN
cord-270892-ycc3csyh	906	59	to	to	TO
cord-270892-ycc3csyh	906	60	live	live	VB
cord-270892-ycc3csyh	906	61	cells	cell	NNS
cord-270892-ycc3csyh	906	62	Structural	structural	JJ
cord-270892-ycc3csyh	906	63	studies	study	NNS
cord-270892-ycc3csyh	906	64	of	of	IN
cord-270892-ycc3csyh	906	65	two	two	CD
cord-270892-ycc3csyh	906	66	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	906	67	serotypes	serotype	NNS
cord-270892-ycc3csyh	906	68	complexed	complexe	VBN
cord-270892-ycc3csyh	906	69	with	with	IN
cord-270892-ycc3csyh	906	70	fragments	fragment	NNS
cord-270892-ycc3csyh	906	71	of	of	IN
cord-270892-ycc3csyh	906	72	their	-PRON-	PRP$
cord-270892-ycc3csyh	906	73	cellular	cellular	JJ
cord-270892-ycc3csyh	906	74	receptor	receptor	NN
cord-270892-ycc3csyh	907	1	The	the	DT
cord-270892-ycc3csyh	907	2	cellular	cellular	JJ
cord-270892-ycc3csyh	907	3	receptor	receptor	NN
cord-270892-ycc3csyh	907	4	to	to	IN
cord-270892-ycc3csyh	907	5	human	human	JJ
cord-270892-ycc3csyh	907	6	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	907	7	2	2	CD
cord-270892-ycc3csyh	907	8	binds	bind	VBZ
cord-270892-ycc3csyh	907	9	around	around	IN
cord-270892-ycc3csyh	907	10	the	the	DT
cord-270892-ycc3csyh	907	11	5-fold	5-fold	CD
cord-270892-ycc3csyh	907	12	axis	axis	NN
cord-270892-ycc3csyh	907	13	and	and	CC
cord-270892-ycc3csyh	907	14	not	not	RB
cord-270892-ycc3csyh	907	15	in	in	IN
cord-270892-ycc3csyh	907	16	the	the	DT
cord-270892-ycc3csyh	907	17	canyon	canyon	NN
cord-270892-ycc3csyh	907	18	:	:	:
cord-270892-ycc3csyh	908	1	A	a	DT
cord-270892-ycc3csyh	908	2	structural	structural	JJ
cord-270892-ycc3csyh	908	3	view	view	NN
cord-270892-ycc3csyh	909	1	The	the	DT
cord-270892-ycc3csyh	909	2	major	major	JJ
cord-270892-ycc3csyh	909	3	and	and	CC
cord-270892-ycc3csyh	909	4	minor	minor	JJ
cord-270892-ycc3csyh	909	5	group	group	NN
cord-270892-ycc3csyh	909	6	receptor	receptor	NN
cord-270892-ycc3csyh	909	7	families	family	NNS
cord-270892-ycc3csyh	909	8	contain	contain	VBP
cord-270892-ycc3csyh	909	9	all	all	DT
cord-270892-ycc3csyh	909	10	but	but	IN
cord-270892-ycc3csyh	909	11	one	one	CD
cord-270892-ycc3csyh	909	12	human	human	JJ
cord-270892-ycc3csyh	909	13	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	909	14	serotype	serotype	NN
cord-270892-ycc3csyh	909	15	Human	human	JJ
cord-270892-ycc3csyh	909	16	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	909	17	type	type	NN
cord-270892-ycc3csyh	909	18	54	54	CD
cord-270892-ycc3csyh	909	19	infection	infection	NN
cord-270892-ycc3csyh	909	20	via	via	IN
cord-270892-ycc3csyh	909	21	heparan	heparan	NN
cord-270892-ycc3csyh	909	22	sulfate	sulfate	NN
cord-270892-ycc3csyh	909	23	is	be	VBZ
cord-270892-ycc3csyh	909	24	less	less	RBR
cord-270892-ycc3csyh	909	25	efficient	efficient	JJ
cord-270892-ycc3csyh	909	26	and	and	CC
cord-270892-ycc3csyh	909	27	strictly	strictly	RB
cord-270892-ycc3csyh	909	28	dependent	dependent	JJ
cord-270892-ycc3csyh	909	29	on	on	IN
cord-270892-ycc3csyh	909	30	low	low	JJ
cord-270892-ycc3csyh	909	31	endosomal	endosomal	NNP
cord-270892-ycc3csyh	909	32	pH	pH	NNP
cord-270892-ycc3csyh	909	33	Human	human	JJ
cord-270892-ycc3csyh	909	34	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	909	35	type	type	NN
cord-270892-ycc3csyh	909	36	89	89	CD
cord-270892-ycc3csyh	909	37	variants	variant	NNS
cord-270892-ycc3csyh	909	38	use	use	VBP
cord-270892-ycc3csyh	909	39	heparan	heparan	NN
cord-270892-ycc3csyh	909	40	sulfate	sulfate	NN
cord-270892-ycc3csyh	909	41	proteoglycan	proteoglycan	NN
cord-270892-ycc3csyh	909	42	for	for	IN
cord-270892-ycc3csyh	909	43	cell	cell	NN
cord-270892-ycc3csyh	909	44	attachment	attachment	NN
cord-270892-ycc3csyh	909	45	Internalization	internalization	NN
cord-270892-ycc3csyh	909	46	of	of	IN
cord-270892-ycc3csyh	909	47	human	human	JJ
cord-270892-ycc3csyh	909	48	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	909	49	14	14	CD
cord-270892-ycc3csyh	909	50	into	into	IN
cord-270892-ycc3csyh	909	51	HeLa	HeLa	NNP
cord-270892-ycc3csyh	909	52	and	and	CC
cord-270892-ycc3csyh	909	53	ICAM-1-transfected	icam-1-transfecte	VBD
cord-270892-ycc3csyh	910	1	BHK	BHK	NNP
cord-270892-ycc3csyh	910	2	cells	cell	NNS
cord-270892-ycc3csyh	911	1	Viral	viral	JJ
cord-270892-ycc3csyh	911	2	evolution	evolution	NN
cord-270892-ycc3csyh	911	3	toward	toward	IN
cord-270892-ycc3csyh	911	4	change	change	NN
cord-270892-ycc3csyh	911	5	in	in	IN
cord-270892-ycc3csyh	911	6	receptor	receptor	NN
cord-270892-ycc3csyh	911	7	usage	usage	NN
cord-270892-ycc3csyh	911	8	:	:	:
cord-270892-ycc3csyh	911	9	Adaptation	adaptation	NN
cord-270892-ycc3csyh	911	10	of	of	IN
cord-270892-ycc3csyh	911	11	a	a	DT
cord-270892-ycc3csyh	911	12	major	major	JJ
cord-270892-ycc3csyh	911	13	group	group	NN
cord-270892-ycc3csyh	911	14	human	human	JJ
cord-270892-ycc3csyh	911	15	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	911	16	to	to	TO
cord-270892-ycc3csyh	911	17	grow	grow	VB
cord-270892-ycc3csyh	911	18	in	in	IN
cord-270892-ycc3csyh	911	19	ICAM-1-negative	icam-1-negative	NN
cord-270892-ycc3csyh	911	20	cells	cell	NNS
cord-270892-ycc3csyh	911	21	Rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	911	22	-	-	HYPH
cord-270892-ycc3csyh	911	23	mediated	mediate	VBN
cord-270892-ycc3csyh	911	24	endosomal	endosomal	NNP
cord-270892-ycc3csyh	911	25	release	release	NN
cord-270892-ycc3csyh	911	26	of	of	IN
cord-270892-ycc3csyh	911	27	transfection	transfection	NN
cord-270892-ycc3csyh	911	28	complexes	complex	NNS
cord-270892-ycc3csyh	911	29	Major	major	JJ
cord-270892-ycc3csyh	911	30	and	and	CC
cord-270892-ycc3csyh	911	31	minor	minor	JJ
cord-270892-ycc3csyh	911	32	receptor	receptor	NN
cord-270892-ycc3csyh	911	33	group	group	NN
cord-270892-ycc3csyh	911	34	human	human	JJ
cord-270892-ycc3csyh	911	35	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	911	36	penetrate	penetrate	VBP
cord-270892-ycc3csyh	911	37	from	from	IN
cord-270892-ycc3csyh	911	38	endosomes	endosome	NNS
cord-270892-ycc3csyh	911	39	by	by	IN
cord-270892-ycc3csyh	911	40	different	different	JJ
cord-270892-ycc3csyh	911	41	mechanisms	mechanism	NNS
cord-270892-ycc3csyh	911	42	Cryoelectron	Cryoelectron	NNP
cord-270892-ycc3csyh	911	43	microscopy	microscopy	NN
cord-270892-ycc3csyh	911	44	analysis	analysis	NN
cord-270892-ycc3csyh	911	45	of	of	IN
cord-270892-ycc3csyh	911	46	the	the	DT
cord-270892-ycc3csyh	911	47	structural	structural	JJ
cord-270892-ycc3csyh	911	48	changes	change	NNS
cord-270892-ycc3csyh	911	49	associated	associate	VBN
cord-270892-ycc3csyh	911	50	with	with	IN
cord-270892-ycc3csyh	911	51	human	human	JJ
cord-270892-ycc3csyh	911	52	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	911	53	type	type	NN
cord-270892-ycc3csyh	911	54	14	14	CD
cord-270892-ycc3csyh	911	55	uncoating	uncoating	NN
cord-270892-ycc3csyh	911	56	Formation	Formation	NNP
cord-270892-ycc3csyh	911	57	of	of	IN
cord-270892-ycc3csyh	911	58	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	911	59	-	-	HYPH
cord-270892-ycc3csyh	911	60	soluble	soluble	JJ
cord-270892-ycc3csyh	911	61	ICAM-1	icam-1	NN
cord-270892-ycc3csyh	911	62	complexes	complex	NNS
cord-270892-ycc3csyh	911	63	and	and	CC
cord-270892-ycc3csyh	911	64	conformational	conformational	JJ
cord-270892-ycc3csyh	911	65	changes	change	NNS
cord-270892-ycc3csyh	911	66	in	in	IN
cord-270892-ycc3csyh	911	67	the	the	DT
cord-270892-ycc3csyh	911	68	virion	virion	NN
cord-270892-ycc3csyh	911	69	Conformational	Conformational	NNP
cord-270892-ycc3csyh	911	70	changes	change	NNS
cord-270892-ycc3csyh	911	71	,	,	,
cord-270892-ycc3csyh	911	72	plasma	plasma	NN
cord-270892-ycc3csyh	911	73	membrane	membrane	NN
cord-270892-ycc3csyh	911	74	penetration	penetration	NN
cord-270892-ycc3csyh	911	75	,	,	,
cord-270892-ycc3csyh	911	76	and	and	CC
cord-270892-ycc3csyh	911	77	infection	infection	NN
cord-270892-ycc3csyh	911	78	by	by	IN
cord-270892-ycc3csyh	911	79	human	human	JJ
cord-270892-ycc3csyh	911	80	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	911	81	type	type	NN
cord-270892-ycc3csyh	911	82	2	2	CD
cord-270892-ycc3csyh	911	83	:	:	:
cord-270892-ycc3csyh	911	84	Role	role	NN
cord-270892-ycc3csyh	911	85	of	of	IN
cord-270892-ycc3csyh	911	86	receptors	receptor	NNS
cord-270892-ycc3csyh	911	87	and	and	CC
cord-270892-ycc3csyh	911	88	low	low	JJ
cord-270892-ycc3csyh	911	89	pH	pH	NNP
cord-270892-ycc3csyh	911	90	Uncoating	Uncoating	NNP
cord-270892-ycc3csyh	911	91	of	of	IN
cord-270892-ycc3csyh	911	92	human	human	JJ
cord-270892-ycc3csyh	911	93	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	911	94	serotype	serotype	NN
cord-270892-ycc3csyh	911	95	2	2	CD
cord-270892-ycc3csyh	911	96	from	from	IN
cord-270892-ycc3csyh	911	97	late	late	JJ
cord-270892-ycc3csyh	911	98	endosomes	endosome	NNS
cord-270892-ycc3csyh	911	99	X	x	NN
cord-270892-ycc3csyh	911	100	-	-	NN
cord-270892-ycc3csyh	911	101	ray	ray	JJ
cord-270892-ycc3csyh	911	102	structure	structure	NN
cord-270892-ycc3csyh	911	103	of	of	IN
cord-270892-ycc3csyh	911	104	a	a	DT
cord-270892-ycc3csyh	911	105	minor	minor	JJ
cord-270892-ycc3csyh	911	106	group	group	NN
cord-270892-ycc3csyh	911	107	human	human	JJ
cord-270892-ycc3csyh	911	108	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	911	109	bound	bind	VBN
cord-270892-ycc3csyh	911	110	to	to	IN
cord-270892-ycc3csyh	911	111	a	a	DT
cord-270892-ycc3csyh	911	112	fragment	fragment	NN
cord-270892-ycc3csyh	911	113	of	of	IN
cord-270892-ycc3csyh	911	114	its	-PRON-	PRP$
cord-270892-ycc3csyh	911	115	cellular	cellular	JJ
cord-270892-ycc3csyh	911	116	receptor	receptor	NN
cord-270892-ycc3csyh	911	117	protein	protein	NN
cord-270892-ycc3csyh	912	1	The	the	DT
cord-270892-ycc3csyh	912	2	expression	expression	NN
cord-270892-ycc3csyh	912	3	and	and	CC
cord-270892-ycc3csyh	912	4	purification	purification	NN
cord-270892-ycc3csyh	912	5	of	of	IN
cord-270892-ycc3csyh	912	6	human	human	JJ
cord-270892-ycc3csyh	912	7	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	912	8	protease	protease	NN
cord-270892-ycc3csyh	912	9	3C	3C	NNP
cord-270892-ycc3csyh	912	10	Polypeptide	Polypeptide	NNP
cord-270892-ycc3csyh	912	11	2A	2a	CD
cord-270892-ycc3csyh	912	12	of	of	IN
cord-270892-ycc3csyh	912	13	human	human	JJ
cord-270892-ycc3csyh	912	14	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	912	15	type	type	NN
cord-270892-ycc3csyh	912	16	2	2	CD
cord-270892-ycc3csyh	912	17	:	:	:
cord-270892-ycc3csyh	912	18	Identification	identification	NN
cord-270892-ycc3csyh	912	19	as	as	IN
cord-270892-ycc3csyh	912	20	a	a	DT
cord-270892-ycc3csyh	912	21	protease	protease	NN
cord-270892-ycc3csyh	912	22	and	and	CC
cord-270892-ycc3csyh	912	23	characterization	characterization	NN
cord-270892-ycc3csyh	912	24	by	by	IN
cord-270892-ycc3csyh	912	25	mutational	mutational	JJ
cord-270892-ycc3csyh	912	26	analysis	analysis	NN
cord-270892-ycc3csyh	913	1	The	the	DT
cord-270892-ycc3csyh	913	2	eIF4G	eif4g	CD
cord-270892-ycc3csyh	913	3	-	-	HYPH
cord-270892-ycc3csyh	913	4	eIF4E	eif4e	CD
cord-270892-ycc3csyh	913	5	complex	complex	NN
cord-270892-ycc3csyh	913	6	is	be	VBZ
cord-270892-ycc3csyh	913	7	the	the	DT
cord-270892-ycc3csyh	913	8	target	target	NN
cord-270892-ycc3csyh	913	9	for	for	IN
cord-270892-ycc3csyh	913	10	direct	direct	JJ
cord-270892-ycc3csyh	913	11	cleavage	cleavage	NN
cord-270892-ycc3csyh	913	12	by	by	IN
cord-270892-ycc3csyh	913	13	the	the	DT
cord-270892-ycc3csyh	913	14	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	913	15	2A	2a	CD
cord-270892-ycc3csyh	913	16	proteinase	proteinase	NN
cord-270892-ycc3csyh	913	17	Purification	Purification	NNP
cord-270892-ycc3csyh	913	18	of	of	IN
cord-270892-ycc3csyh	913	19	two	two	CD
cord-270892-ycc3csyh	913	20	picornaviral	picornaviral	NNP
cord-270892-ycc3csyh	913	21	2A	2A	NNP
cord-270892-ycc3csyh	913	22	proteinases	proteinases	NNP
cord-270892-ycc3csyh	913	23	:	:	:
cord-270892-ycc3csyh	913	24	Interaction	Interaction	NNP
cord-270892-ycc3csyh	913	25	with	with	IN
cord-270892-ycc3csyh	913	26	eIF-4	eIF-4	NNP
cord-270892-ycc3csyh	913	27	gamma	gamma	NN
cord-270892-ycc3csyh	913	28	and	and	CC
cord-270892-ycc3csyh	913	29	influence	influence	NN
cord-270892-ycc3csyh	913	30	on	on	IN
cord-270892-ycc3csyh	913	31	in	in	IN
cord-270892-ycc3csyh	913	32	vitro	vitro	FW
cord-270892-ycc3csyh	913	33	translation	translation	NN
cord-270892-ycc3csyh	914	1	2A	2A	NNP
cord-270892-ycc3csyh	914	2	proteinases	proteinases	NNP
cord-270892-ycc3csyh	914	3	of	of	IN
cord-270892-ycc3csyh	914	4	coxsackie	coxsackie	NNP
cord-270892-ycc3csyh	914	5	-	-	:
cord-270892-ycc3csyh	914	6	and	and	CC
cord-270892-ycc3csyh	914	7	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	914	8	cleave	cleave	NN
cord-270892-ycc3csyh	914	9	peptides	peptide	NNS
cord-270892-ycc3csyh	914	10	derived	derive	VBN
cord-270892-ycc3csyh	914	11	from	from	IN
cord-270892-ycc3csyh	914	12	eIF-4	eIF-4	NNP
cord-270892-ycc3csyh	914	13	gamma	gamma	NN
cord-270892-ycc3csyh	914	14	via	via	IN
cord-270892-ycc3csyh	914	15	a	a	DT
cord-270892-ycc3csyh	914	16	common	common	JJ
cord-270892-ycc3csyh	914	17	recognition	recognition	NN
cord-270892-ycc3csyh	914	18	motif	motif	NN
cord-270892-ycc3csyh	914	19	Conservation	conservation	NN
cord-270892-ycc3csyh	914	20	of	of	IN
cord-270892-ycc3csyh	914	21	amino	amino	JJ
cord-270892-ycc3csyh	914	22	acids	acid	NNS
cord-270892-ycc3csyh	914	23	in	in	IN
cord-270892-ycc3csyh	914	24	human	human	JJ
cord-270892-ycc3csyh	914	25	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	914	26	3C	3C	NNP
cord-270892-ycc3csyh	914	27	protease	protease	NNP
cord-270892-ycc3csyh	914	28	correlates	correlate	VBZ
cord-270892-ycc3csyh	914	29	with	with	IN
cord-270892-ycc3csyh	914	30	broad	broad	JJ
cord-270892-ycc3csyh	914	31	-	-	HYPH
cord-270892-ycc3csyh	914	32	spectrum	spectrum	NN
cord-270892-ycc3csyh	914	33	antiviral	antiviral	JJ
cord-270892-ycc3csyh	914	34	activity	activity	NN
cord-270892-ycc3csyh	914	35	of	of	IN
cord-270892-ycc3csyh	914	36	rupintrivir	rupintrivir	NNP
cord-270892-ycc3csyh	914	37	,	,	,
cord-270892-ycc3csyh	914	38	a	a	DT
cord-270892-ycc3csyh	914	39	novel	novel	JJ
cord-270892-ycc3csyh	914	40	human	human	JJ
cord-270892-ycc3csyh	914	41	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	914	42	3C	3C	NNP
cord-270892-ycc3csyh	914	43	protease	protease	NN
cord-270892-ycc3csyh	914	44	inhibitor	inhibitor	NN
cord-270892-ycc3csyh	914	45	Fields	Fields	NNP
cord-270892-ycc3csyh	914	46	virology	virology	NN
cord-270892-ycc3csyh	915	1	Rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	915	2	infects	infect	VBZ
cord-270892-ycc3csyh	915	3	primary	primary	JJ
cord-270892-ycc3csyh	915	4	human	human	JJ
cord-270892-ycc3csyh	915	5	airway	airway	NN
cord-270892-ycc3csyh	915	6	fibroblasts	fibroblast	NNS
cord-270892-ycc3csyh	915	7	and	and	CC
cord-270892-ycc3csyh	915	8	induces	induce	VBZ
cord-270892-ycc3csyh	915	9	a	a	DT
cord-270892-ycc3csyh	915	10	neutrophil	neutrophil	NN
cord-270892-ycc3csyh	915	11	chemokine	chemokine	NN
cord-270892-ycc3csyh	915	12	and	and	CC
cord-270892-ycc3csyh	915	13	a	a	DT
cord-270892-ycc3csyh	915	14	permeability	permeability	NN
cord-270892-ycc3csyh	915	15	factor	factor	NN
cord-270892-ycc3csyh	915	16	Basal	Basal	NNP
cord-270892-ycc3csyh	915	17	cells	cell	NNS
cord-270892-ycc3csyh	915	18	of	of	IN
cord-270892-ycc3csyh	915	19	differentiated	differentiated	JJ
cord-270892-ycc3csyh	915	20	bronchial	bronchial	JJ
cord-270892-ycc3csyh	915	21	epithelium	epithelium	NN
cord-270892-ycc3csyh	915	22	are	be	VBP
cord-270892-ycc3csyh	915	23	more	more	RBR
cord-270892-ycc3csyh	915	24	susceptible	susceptible	JJ
cord-270892-ycc3csyh	915	25	to	to	IN
cord-270892-ycc3csyh	915	26	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	915	27	infection	infection	NN
cord-270892-ycc3csyh	915	28	Resistance	resistance	NN
cord-270892-ycc3csyh	915	29	of	of	IN
cord-270892-ycc3csyh	915	30	differentiated	differentiated	JJ
cord-270892-ycc3csyh	915	31	human	human	JJ
cord-270892-ycc3csyh	915	32	airway	airway	NN
cord-270892-ycc3csyh	915	33	epithelium	epithelium	NN
cord-270892-ycc3csyh	915	34	to	to	IN
cord-270892-ycc3csyh	915	35	infection	infection	NN
cord-270892-ycc3csyh	915	36	by	by	IN
cord-270892-ycc3csyh	915	37	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	915	38	Effect	Effect	NNP
cord-270892-ycc3csyh	915	39	of	of	IN
cord-270892-ycc3csyh	915	40	isoflavans	isoflavans	NNPS
cord-270892-ycc3csyh	915	41	and	and	CC
cord-270892-ycc3csyh	915	42	isoflavenes	isoflavenes	NNPS
cord-270892-ycc3csyh	915	43	on	on	IN
cord-270892-ycc3csyh	915	44	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	915	45	1B	1b	CD
cord-270892-ycc3csyh	915	46	and	and	CC
cord-270892-ycc3csyh	915	47	its	-PRON-	PRP$
cord-270892-ycc3csyh	915	48	replication	replication	NN
cord-270892-ycc3csyh	915	49	in	in	IN
cord-270892-ycc3csyh	915	50	HeLa	HeLa	NNP
cord-270892-ycc3csyh	915	51	cells	cell	NNS
cord-270892-ycc3csyh	915	52	Enantiomeric	enantiomeric	JJ
cord-270892-ycc3csyh	915	53	effects	effect	NNS
cord-270892-ycc3csyh	915	54	of	of	IN
cord-270892-ycc3csyh	915	55	homologues	homologue	NNS
cord-270892-ycc3csyh	915	56	of	of	IN
cord-270892-ycc3csyh	915	57	disoxaril	disoxaril	NNP
cord-270892-ycc3csyh	915	58	on	on	IN
cord-270892-ycc3csyh	915	59	the	the	DT
cord-270892-ycc3csyh	915	60	inhibitory	inhibitory	JJ
cord-270892-ycc3csyh	915	61	activity	activity	NN
cord-270892-ycc3csyh	915	62	against	against	IN
cord-270892-ycc3csyh	915	63	human	human	JJ
cord-270892-ycc3csyh	915	64	rhinovirus-14	rhinovirus-14	NN
cord-270892-ycc3csyh	916	1	In	in	IN
cord-270892-ycc3csyh	916	2	vitro	vitro	FW
cord-270892-ycc3csyh	916	3	activity	activity	NN
cord-270892-ycc3csyh	916	4	of	of	IN
cord-270892-ycc3csyh	916	5	WIN	WIN	NNP
cord-270892-ycc3csyh	916	6	51711	51711	CD
cord-270892-ycc3csyh	916	7	,	,	,
cord-270892-ycc3csyh	916	8	a	a	DT
cord-270892-ycc3csyh	916	9	new	new	JJ
cord-270892-ycc3csyh	916	10	broad	broad	JJ
cord-270892-ycc3csyh	916	11	-	-	HYPH
cord-270892-ycc3csyh	916	12	spectrum	spectrum	NN
cord-270892-ycc3csyh	916	13	antipicornavirus	antipicornavirus	NNP
cord-270892-ycc3csyh	916	14	drug	drug	NN
cord-270892-ycc3csyh	916	15	Two	two	CD
cord-270892-ycc3csyh	916	16	groups	group	NNS
cord-270892-ycc3csyh	916	17	of	of	IN
cord-270892-ycc3csyh	916	18	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	916	19	revealed	reveal	VBN
cord-270892-ycc3csyh	916	20	by	by	IN
cord-270892-ycc3csyh	916	21	a	a	DT
cord-270892-ycc3csyh	916	22	panel	panel	NN
cord-270892-ycc3csyh	916	23	of	of	IN
cord-270892-ycc3csyh	916	24	antiviral	antiviral	JJ
cord-270892-ycc3csyh	916	25	compounds	compound	NNS
cord-270892-ycc3csyh	916	26	present	present	VBP
cord-270892-ycc3csyh	916	27	sequence	sequence	NN
cord-270892-ycc3csyh	916	28	divergence	divergence	NN
cord-270892-ycc3csyh	916	29	and	and	CC
cord-270892-ycc3csyh	916	30	differential	differential	JJ
cord-270892-ycc3csyh	916	31	pathogenicity	pathogenicity	NN
cord-270892-ycc3csyh	917	1	An	an	DT
cord-270892-ycc3csyh	917	2	orally	orally	RB
cord-270892-ycc3csyh	917	3	bioavailable	bioavailable	JJ
cord-270892-ycc3csyh	917	4	oxime	oxime	NN
cord-270892-ycc3csyh	917	5	ether	ether	NN
cord-270892-ycc3csyh	917	6	capsid	capsid	NN
cord-270892-ycc3csyh	917	7	binder	binder	NN
cord-270892-ycc3csyh	917	8	with	with	IN
cord-270892-ycc3csyh	917	9	potent	potent	JJ
cord-270892-ycc3csyh	917	10	activity	activity	NN
cord-270892-ycc3csyh	917	11	against	against	IN
cord-270892-ycc3csyh	917	12	human	human	JJ
cord-270892-ycc3csyh	917	13	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	918	1	In	in	IN
cord-270892-ycc3csyh	918	2	vitro	vitro	FW
cord-270892-ycc3csyh	918	3	activity	activity	NN
cord-270892-ycc3csyh	918	4	of	of	IN
cord-270892-ycc3csyh	918	5	expanded	expand	VBN
cord-270892-ycc3csyh	918	6	-	-	HYPH
cord-270892-ycc3csyh	918	7	spectrum	spectrum	NN
cord-270892-ycc3csyh	918	8	pyridazinyl	pyridazinyl	NN
cord-270892-ycc3csyh	918	9	oxime	oxime	NN
cord-270892-ycc3csyh	918	10	ethers	ether	NNS
cord-270892-ycc3csyh	918	11	related	relate	VBN
cord-270892-ycc3csyh	918	12	to	to	IN
cord-270892-ycc3csyh	918	13	pirodavir	pirodavir	NNP
cord-270892-ycc3csyh	918	14	:	:	:
cord-270892-ycc3csyh	918	15	novel	novel	JJ
cord-270892-ycc3csyh	918	16	capsid	capsid	RB
cord-270892-ycc3csyh	918	17	-	-	HYPH
cord-270892-ycc3csyh	918	18	binding	bind	VBG
cord-270892-ycc3csyh	918	19	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	918	20	with	with	IN
cord-270892-ycc3csyh	918	21	potent	potent	JJ
cord-270892-ycc3csyh	918	22	antipicornavirus	antipicornavirus	JJ
cord-270892-ycc3csyh	918	23	activity	activity	NN
cord-270892-ycc3csyh	919	1	Novel	novel	NN
cord-270892-ycc3csyh	919	2	[	[	-LRB-
cord-270892-ycc3csyh	919	3	(	(	-LRB-
cord-270892-ycc3csyh	919	4	biphenyloxy)propyl]-isoxazole	biphenyloxy)propyl]-isoxazole	NNP
cord-270892-ycc3csyh	919	5	derivatives	derivative	NNS
cord-270892-ycc3csyh	919	6	for	for	IN
cord-270892-ycc3csyh	919	7	inhibition	inhibition	NN
cord-270892-ycc3csyh	919	8	of	of	IN
cord-270892-ycc3csyh	919	9	human	human	JJ
cord-270892-ycc3csyh	919	10	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	919	11	2	2	CD
cord-270892-ycc3csyh	919	12	and	and	CC
cord-270892-ycc3csyh	919	13	coxsackievirus	coxsackievirus	NNP
cord-270892-ycc3csyh	919	14	B3	B3	NNP
cord-270892-ycc3csyh	919	15	replication	replication	NN
cord-270892-ycc3csyh	919	16	Structure	structure	NN
cord-270892-ycc3csyh	919	17	-	-	HYPH
cord-270892-ycc3csyh	919	18	based	base	VBN
cord-270892-ycc3csyh	919	19	virtual	virtual	JJ
cord-270892-ycc3csyh	919	20	screening	screening	NN
cord-270892-ycc3csyh	919	21	for	for	IN
cord-270892-ycc3csyh	919	22	the	the	DT
cord-270892-ycc3csyh	919	23	discovery	discovery	NN
cord-270892-ycc3csyh	919	24	of	of	IN
cord-270892-ycc3csyh	919	25	natural	natural	JJ
cord-270892-ycc3csyh	919	26	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	919	27	for	for	IN
cord-270892-ycc3csyh	919	28	human	human	JJ
cord-270892-ycc3csyh	919	29	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	919	30	coat	coat	NN
cord-270892-ycc3csyh	919	31	protein	protein	NNP
cord-270892-ycc3csyh	920	1	In	in	IN
cord-270892-ycc3csyh	920	2	vitro	vitro	FW
cord-270892-ycc3csyh	920	3	resistance	resistance	NN
cord-270892-ycc3csyh	920	4	study	study	NN
cord-270892-ycc3csyh	920	5	of	of	IN
cord-270892-ycc3csyh	920	6	rupintrivir	rupintrivir	NNP
cord-270892-ycc3csyh	920	7	,	,	,
cord-270892-ycc3csyh	920	8	a	a	DT
cord-270892-ycc3csyh	920	9	novel	novel	JJ
cord-270892-ycc3csyh	920	10	inhibitor	inhibitor	NN
cord-270892-ycc3csyh	920	11	of	of	IN
cord-270892-ycc3csyh	920	12	human	human	JJ
cord-270892-ycc3csyh	920	13	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	920	14	3C	3C	NNP
cord-270892-ycc3csyh	920	15	protease	protease	NNP
cord-270892-ycc3csyh	920	16	Establishment	Establishment	NNP
cord-270892-ycc3csyh	920	17	of	of	IN
cord-270892-ycc3csyh	920	18	a	a	DT
cord-270892-ycc3csyh	920	19	mouse	mouse	NN
cord-270892-ycc3csyh	920	20	model	model	NN
cord-270892-ycc3csyh	920	21	for	for	IN
cord-270892-ycc3csyh	920	22	human	human	JJ
cord-270892-ycc3csyh	920	23	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	920	24	infection	infection	NN
cord-270892-ycc3csyh	920	25	Human	human	JJ
cord-270892-ycc3csyh	920	26	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	920	27	1B	1b	CD
cord-270892-ycc3csyh	920	28	exposure	exposure	NN
cord-270892-ycc3csyh	920	29	induces	induce	VBZ
cord-270892-ycc3csyh	920	30	phosphatidylinositol	phosphatidylinositol	JJ
cord-270892-ycc3csyh	920	31	3-kinase	3-kinase	CD
cord-270892-ycc3csyh	920	32	-	-	HYPH
cord-270892-ycc3csyh	920	33	dependent	dependent	JJ
cord-270892-ycc3csyh	920	34	airway	airway	NN
cord-270892-ycc3csyh	920	35	inflammation	inflammation	NN
cord-270892-ycc3csyh	920	36	in	in	IN
cord-270892-ycc3csyh	920	37	mice	mouse	NNS
cord-270892-ycc3csyh	920	38	Mouse	Mouse	NNP
cord-270892-ycc3csyh	920	39	models	model	NNS
cord-270892-ycc3csyh	920	40	of	of	IN
cord-270892-ycc3csyh	920	41	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	920	42	-	-	HYPH
cord-270892-ycc3csyh	920	43	induced	induce	VBN
cord-270892-ycc3csyh	920	44	disease	disease	NN
cord-270892-ycc3csyh	920	45	and	and	CC
cord-270892-ycc3csyh	920	46	exacerbation	exacerbation	NN
cord-270892-ycc3csyh	920	47	of	of	IN
cord-270892-ycc3csyh	920	48	allergic	allergic	JJ
cord-270892-ycc3csyh	920	49	airway	airway	NN
cord-270892-ycc3csyh	920	50	inflammation	inflammation	NN
cord-270892-ycc3csyh	920	51	Prophylactic	prophylactic	JJ
cord-270892-ycc3csyh	920	52	activity	activity	NN
cord-270892-ycc3csyh	920	53	of	of	IN
cord-270892-ycc3csyh	920	54	intranasal	intranasal	NN
cord-270892-ycc3csyh	920	55	enviroxime	enviroxime	NN
cord-270892-ycc3csyh	920	56	against	against	IN
cord-270892-ycc3csyh	920	57	experimentally	experimentally	RB
cord-270892-ycc3csyh	920	58	induced	induce	VBN
cord-270892-ycc3csyh	920	59	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	920	60	type	type	NN
cord-270892-ycc3csyh	920	61	39	39	CD
cord-270892-ycc3csyh	920	62	infection	infection	NN
cord-270892-ycc3csyh	921	1	Intranasal	intranasal	NN
cord-270892-ycc3csyh	921	2	interferon	interferon	NN
cord-270892-ycc3csyh	921	3	-	-	HYPH
cord-270892-ycc3csyh	921	4	alpha	alpha	NN
cord-270892-ycc3csyh	921	5	2	2	CD
cord-270892-ycc3csyh	921	6	treatment	treatment	NN
cord-270892-ycc3csyh	921	7	of	of	IN
cord-270892-ycc3csyh	921	8	experimental	experimental	JJ
cord-270892-ycc3csyh	921	9	rhinoviral	rhinoviral	JJ
cord-270892-ycc3csyh	921	10	colds	cold	NNS
cord-270892-ycc3csyh	921	11	Topical	topical	JJ
cord-270892-ycc3csyh	921	12	enviroxime	enviroxime	NN
cord-270892-ycc3csyh	921	13	against	against	IN
cord-270892-ycc3csyh	921	14	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	921	15	infection	infection	NN
cord-270892-ycc3csyh	921	16	Therapeutic	therapeutic	JJ
cord-270892-ycc3csyh	921	17	activity	activity	NN
cord-270892-ycc3csyh	921	18	of	of	IN
cord-270892-ycc3csyh	921	19	enviroxime	enviroxime	NN
cord-270892-ycc3csyh	921	20	against	against	IN
cord-270892-ycc3csyh	921	21	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	921	22	infection	infection	NN
cord-270892-ycc3csyh	921	23	in	in	IN
cord-270892-ycc3csyh	921	24	volunteers	volunteer	NNS
cord-270892-ycc3csyh	921	25	Efficacy	Efficacy	NNP
cord-270892-ycc3csyh	921	26	of	of	IN
cord-270892-ycc3csyh	921	27	oral	oral	JJ
cord-270892-ycc3csyh	921	28	WIN	WIN	NNP
cord-270892-ycc3csyh	921	29	54954	54954	CD
cord-270892-ycc3csyh	921	30	for	for	IN
cord-270892-ycc3csyh	921	31	prophylaxis	prophylaxis	NN
cord-270892-ycc3csyh	921	32	of	of	IN
cord-270892-ycc3csyh	921	33	experimental	experimental	JJ
cord-270892-ycc3csyh	921	34	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	921	35	infection	infection	NN
cord-270892-ycc3csyh	921	36	Ineffectiveness	Ineffectiveness	NNP
cord-270892-ycc3csyh	921	37	of	of	IN
cord-270892-ycc3csyh	921	38	echinacea	echinacea	NN
cord-270892-ycc3csyh	921	39	for	for	IN
cord-270892-ycc3csyh	921	40	prevention	prevention	NN
cord-270892-ycc3csyh	921	41	of	of	IN
cord-270892-ycc3csyh	921	42	experimental	experimental	JJ
cord-270892-ycc3csyh	921	43	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	921	44	colds	cold	NNS
cord-270892-ycc3csyh	922	1	Current	current	JJ
cord-270892-ycc3csyh	922	2	status	status	NN
cord-270892-ycc3csyh	922	3	of	of	IN
cord-270892-ycc3csyh	922	4	anti	anti	JJ
cord-270892-ycc3csyh	922	5	-	-	JJ
cord-270892-ycc3csyh	922	6	picornavirus	picornavirus	JJ
cord-270892-ycc3csyh	922	7	therapies	therapy	NNS
cord-270892-ycc3csyh	922	8	Selective	selective	JJ
cord-270892-ycc3csyh	922	9	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	922	10	of	of	IN
cord-270892-ycc3csyh	922	11	picornavirus	picornavirus	NNP
cord-270892-ycc3csyh	922	12	replication	replication	NN
cord-270892-ycc3csyh	922	13	Inhibitors	Inhibitors	NNP
cord-270892-ycc3csyh	922	14	of	of	IN
cord-270892-ycc3csyh	922	15	3C	3C	NNP
cord-270892-ycc3csyh	922	16	cysteine	cysteine	NNP
cord-270892-ycc3csyh	922	17	proteinases	proteinases	NNP
cord-270892-ycc3csyh	922	18	from	from	IN
cord-270892-ycc3csyh	922	19	Picornaviridae	Picornaviridae	NNP
cord-270892-ycc3csyh	922	20	Isolation	Isolation	NNP
cord-270892-ycc3csyh	922	21	of	of	IN
cord-270892-ycc3csyh	922	22	a	a	DT
cord-270892-ycc3csyh	922	23	monoclonal	monoclonal	JJ
cord-270892-ycc3csyh	922	24	antibody	antibody	NN
cord-270892-ycc3csyh	922	25	that	that	WDT
cord-270892-ycc3csyh	922	26	blocks	block	VBZ
cord-270892-ycc3csyh	922	27	attachment	attachment	NN
cord-270892-ycc3csyh	922	28	of	of	IN
cord-270892-ycc3csyh	922	29	the	the	DT
cord-270892-ycc3csyh	922	30	major	major	JJ
cord-270892-ycc3csyh	922	31	group	group	NN
cord-270892-ycc3csyh	922	32	of	of	IN
cord-270892-ycc3csyh	922	33	human	human	JJ
cord-270892-ycc3csyh	922	34	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	922	35	An	an	DT
cord-270892-ycc3csyh	922	36	antibody	antibody	NN
cord-270892-ycc3csyh	922	37	fragment	fragment	NN
cord-270892-ycc3csyh	922	38	from	from	IN
cord-270892-ycc3csyh	922	39	a	a	DT
cord-270892-ycc3csyh	922	40	phage	phage	NN
cord-270892-ycc3csyh	922	41	display	display	NN
cord-270892-ycc3csyh	922	42	library	library	NN
cord-270892-ycc3csyh	922	43	competes	compete	VBZ
cord-270892-ycc3csyh	922	44	for	for	IN
cord-270892-ycc3csyh	922	45	ligand	ligand	NN
cord-270892-ycc3csyh	922	46	binding	binding	NN
cord-270892-ycc3csyh	922	47	to	to	IN
cord-270892-ycc3csyh	922	48	the	the	DT
cord-270892-ycc3csyh	922	49	low	low	JJ
cord-270892-ycc3csyh	922	50	density	density	NN
cord-270892-ycc3csyh	922	51	lipoprotein	lipoprotein	NN
cord-270892-ycc3csyh	922	52	receptor	receptor	NN
cord-270892-ycc3csyh	922	53	family	family	NN
cord-270892-ycc3csyh	922	54	and	and	CC
cord-270892-ycc3csyh	922	55	inhibits	inhibit	VBZ
cord-270892-ycc3csyh	922	56	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	922	57	infection	infection	NN
cord-270892-ycc3csyh	922	58	Modification	modification	NN
cord-270892-ycc3csyh	922	59	of	of	IN
cord-270892-ycc3csyh	922	60	experimental	experimental	JJ
cord-270892-ycc3csyh	922	61	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	922	62	colds	cold	NNS
cord-270892-ycc3csyh	922	63	by	by	IN
cord-270892-ycc3csyh	922	64	receptor	receptor	NN
cord-270892-ycc3csyh	922	65	blockade	blockade	NN
cord-270892-ycc3csyh	922	66	Viral	viral	JJ
cord-270892-ycc3csyh	922	67	receptor	receptor	NN
cord-270892-ycc3csyh	922	68	blockage	blockage	NN
cord-270892-ycc3csyh	922	69	by	by	IN
cord-270892-ycc3csyh	922	70	multivalent	multivalent	JJ
cord-270892-ycc3csyh	922	71	recombinant	recombinant	JJ
cord-270892-ycc3csyh	922	72	antibody	antibody	NN
cord-270892-ycc3csyh	922	73	fusion	fusion	NN
cord-270892-ycc3csyh	922	74	proteins	protein	NNS
cord-270892-ycc3csyh	922	75	:	:	:
cord-270892-ycc3csyh	923	1	Inhibiting	inhibit	VBG
cord-270892-ycc3csyh	923	2	human	human	JJ
cord-270892-ycc3csyh	923	3	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	923	4	(	(	-LRB-
cord-270892-ycc3csyh	923	5	HRV	HRV	NNP
cord-270892-ycc3csyh	923	6	)	)	-RRB-
cord-270892-ycc3csyh	923	7	infection	infection	NN
cord-270892-ycc3csyh	923	8	with	with	IN
cord-270892-ycc3csyh	923	9	CFY196	CFY196	NNP
cord-270892-ycc3csyh	923	10	Comparative	comparative	JJ
cord-270892-ycc3csyh	923	11	antirhinoviral	antirhinoviral	JJ
cord-270892-ycc3csyh	923	12	activities	activity	NNS
cord-270892-ycc3csyh	923	13	of	of	IN
cord-270892-ycc3csyh	923	14	soluble	soluble	JJ
cord-270892-ycc3csyh	923	15	intercellular	intercellular	JJ
cord-270892-ycc3csyh	923	16	adhesion	adhesion	NN
cord-270892-ycc3csyh	923	17	molecule-1	molecule-1	NNP
cord-270892-ycc3csyh	923	18	(	(	-LRB-
cord-270892-ycc3csyh	923	19	sICAM-1	sICAM-1	NNP
cord-270892-ycc3csyh	923	20	)	)	-RRB-
cord-270892-ycc3csyh	923	21	and	and	CC
cord-270892-ycc3csyh	923	22	chimeric	chimeric	JJ
cord-270892-ycc3csyh	923	23	ICAM-1	icam-1	NN
cord-270892-ycc3csyh	923	24	/	/	SYM
cord-270892-ycc3csyh	923	25	immunoglobulin	immunoglobulin	NN
cord-270892-ycc3csyh	923	26	A	a	DT
cord-270892-ycc3csyh	923	27	molecule	molecule	NN
cord-270892-ycc3csyh	924	1	A	a	DT
cord-270892-ycc3csyh	924	2	soluble	soluble	JJ
cord-270892-ycc3csyh	924	3	form	form	NN
cord-270892-ycc3csyh	924	4	of	of	IN
cord-270892-ycc3csyh	924	5	intercellular	intercellular	JJ
cord-270892-ycc3csyh	924	6	adhesion	adhesion	NN
cord-270892-ycc3csyh	925	1	molecule-1	molecule-1	NNP
cord-270892-ycc3csyh	925	2	inhibits	inhibit	VBZ
cord-270892-ycc3csyh	925	3	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	925	4	infection	infection	NN
cord-270892-ycc3csyh	925	5	Spectrum	Spectrum	NNP
cord-270892-ycc3csyh	925	6	of	of	IN
cord-270892-ycc3csyh	925	7	activity	activity	NN
cord-270892-ycc3csyh	925	8	of	of	IN
cord-270892-ycc3csyh	925	9	soluble	soluble	JJ
cord-270892-ycc3csyh	925	10	intercellular	intercellular	JJ
cord-270892-ycc3csyh	925	11	adhesion	adhesion	NN
cord-270892-ycc3csyh	925	12	molecule-1	molecule-1	NNP
cord-270892-ycc3csyh	925	13	against	against	IN
cord-270892-ycc3csyh	925	14	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	925	15	reference	reference	NN
cord-270892-ycc3csyh	925	16	strains	strain	NNS
cord-270892-ycc3csyh	925	17	and	and	CC
cord-270892-ycc3csyh	925	18	field	field	NN
cord-270892-ycc3csyh	925	19	isolates	isolate	NNS
cord-270892-ycc3csyh	925	20	Soluble	soluble	JJ
cord-270892-ycc3csyh	925	21	LDL	LDL	NNP
cord-270892-ycc3csyh	925	22	minireceptors	minireceptor	NNS
cord-270892-ycc3csyh	925	23	.	.	.
cord-270892-ycc3csyh	926	1	Minimal	minimal	JJ
cord-270892-ycc3csyh	926	2	structure	structure	NN
cord-270892-ycc3csyh	926	3	requirements	requirement	NNS
cord-270892-ycc3csyh	926	4	for	for	IN
cord-270892-ycc3csyh	926	5	recognition	recognition	NN
cord-270892-ycc3csyh	926	6	of	of	IN
cord-270892-ycc3csyh	926	7	minor	minor	JJ
cord-270892-ycc3csyh	926	8	group	group	NN
cord-270892-ycc3csyh	926	9	human	human	JJ
cord-270892-ycc3csyh	926	10	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	926	11	Neutralization	neutralization	NN
cord-270892-ycc3csyh	926	12	of	of	IN
cord-270892-ycc3csyh	926	13	a	a	DT
cord-270892-ycc3csyh	926	14	common	common	JJ
cord-270892-ycc3csyh	926	15	cold	cold	JJ
cord-270892-ycc3csyh	926	16	virus	virus	NN
cord-270892-ycc3csyh	926	17	by	by	IN
cord-270892-ycc3csyh	926	18	concatemers	concatemer	NNS
cord-270892-ycc3csyh	926	19	of	of	IN
cord-270892-ycc3csyh	926	20	the	the	DT
cord-270892-ycc3csyh	926	21	third	third	JJ
cord-270892-ycc3csyh	926	22	ligand	ligand	NN
cord-270892-ycc3csyh	926	23	binding	binding	NN
cord-270892-ycc3csyh	926	24	module	module	NN
cord-270892-ycc3csyh	926	25	of	of	IN
cord-270892-ycc3csyh	926	26	the	the	DT
cord-270892-ycc3csyh	926	27	VLDL	vldl	NN
cord-270892-ycc3csyh	926	28	-	-	HYPH
cord-270892-ycc3csyh	926	29	receptor	receptor	NN
cord-270892-ycc3csyh	926	30	strongly	strongly	RB
cord-270892-ycc3csyh	926	31	depends	depend	VBZ
cord-270892-ycc3csyh	926	32	on	on	IN
cord-270892-ycc3csyh	926	33	the	the	DT
cord-270892-ycc3csyh	926	34	number	number	NN
cord-270892-ycc3csyh	926	35	of	of	IN
cord-270892-ycc3csyh	926	36	modules	module	NNS
cord-270892-ycc3csyh	926	37	Rhinovirus	Rhinovirus	NNP
cord-270892-ycc3csyh	926	38	-	-	HYPH
cord-270892-ycc3csyh	926	39	stabilizing	stabilize	VBG
cord-270892-ycc3csyh	926	40	activity	activity	NN
cord-270892-ycc3csyh	926	41	of	of	IN
cord-270892-ycc3csyh	926	42	artificial	artificial	JJ
cord-270892-ycc3csyh	926	43	VLDL	vldl	NN
cord-270892-ycc3csyh	926	44	-	-	HYPH
cord-270892-ycc3csyh	926	45	receptor	receptor	NN
cord-270892-ycc3csyh	926	46	variants	variant	NNS
cord-270892-ycc3csyh	926	47	defines	define	VBZ
cord-270892-ycc3csyh	926	48	a	a	DT
cord-270892-ycc3csyh	926	49	new	new	JJ
cord-270892-ycc3csyh	926	50	mechanism	mechanism	NN
cord-270892-ycc3csyh	926	51	for	for	IN
cord-270892-ycc3csyh	926	52	virus	virus	NN
cord-270892-ycc3csyh	926	53	neutralization	neutralization	NN
cord-270892-ycc3csyh	926	54	by	by	IN
cord-270892-ycc3csyh	926	55	soluble	soluble	JJ
cord-270892-ycc3csyh	926	56	receptors	receptor	NNS
cord-270892-ycc3csyh	927	1	In	in	IN
cord-270892-ycc3csyh	927	2	vitro	vitro	FW
cord-270892-ycc3csyh	927	3	studies	study	NNS
cord-270892-ycc3csyh	927	4	of	of	IN
cord-270892-ycc3csyh	927	5	the	the	DT
cord-270892-ycc3csyh	927	6	antirhinovirus	antirhinovirus	JJ
cord-270892-ycc3csyh	927	7	activity	activity	NN
cord-270892-ycc3csyh	927	8	of	of	IN
cord-270892-ycc3csyh	927	9	soluble	soluble	JJ
cord-270892-ycc3csyh	927	10	intercellular	intercellular	JJ
cord-270892-ycc3csyh	927	11	adhesion	adhesion	NN
cord-270892-ycc3csyh	927	12	molecule-1	molecule-1	NNP
cord-270892-ycc3csyh	927	13	Mechanisms	Mechanisms	NNPS
cord-270892-ycc3csyh	927	14	of	of	IN
cord-270892-ycc3csyh	927	15	receptor	receptor	NN
cord-270892-ycc3csyh	927	16	-	-	HYPH
cord-270892-ycc3csyh	927	17	mediated	mediate	VBN
cord-270892-ycc3csyh	927	18	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	927	19	neutralization	neutralization	NN
cord-270892-ycc3csyh	927	20	defined	define	VBN
cord-270892-ycc3csyh	927	21	by	by	IN
cord-270892-ycc3csyh	927	22	two	two	CD
cord-270892-ycc3csyh	927	23	soluble	soluble	JJ
cord-270892-ycc3csyh	927	24	forms	form	NNS
cord-270892-ycc3csyh	927	25	of	of	IN
cord-270892-ycc3csyh	927	26	ICAM-1	icam-1	JJ
cord-270892-ycc3csyh	927	27	Efficient	efficient	JJ
cord-270892-ycc3csyh	927	28	neutralization	neutralization	NN
cord-270892-ycc3csyh	927	29	and	and	CC
cord-270892-ycc3csyh	927	30	disruption	disruption	NN
cord-270892-ycc3csyh	927	31	of	of	IN
cord-270892-ycc3csyh	927	32	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	927	33	by	by	IN
cord-270892-ycc3csyh	927	34	chimeric	chimeric	JJ
cord-270892-ycc3csyh	927	35	ICAM-1	icam-1	NN
cord-270892-ycc3csyh	927	36	/	/	SYM
cord-270892-ycc3csyh	927	37	immunoglobulin	immunoglobulin	NN
cord-270892-ycc3csyh	927	38	molecules	molecule	NNS
cord-270892-ycc3csyh	928	1	Recombinant	recombinant	JJ
cord-270892-ycc3csyh	928	2	soluble	soluble	JJ
cord-270892-ycc3csyh	928	3	low	low	JJ
cord-270892-ycc3csyh	928	4	density	density	NN
cord-270892-ycc3csyh	928	5	lipoprotein	lipoprotein	NN
cord-270892-ycc3csyh	928	6	receptor	receptor	NN
cord-270892-ycc3csyh	928	7	fragment	fragment	NN
cord-270892-ycc3csyh	928	8	inhibits	inhibit	VBZ
cord-270892-ycc3csyh	928	9	minor	minor	JJ
cord-270892-ycc3csyh	928	10	group	group	NN
cord-270892-ycc3csyh	928	11	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	928	12	infection	infection	NN
cord-270892-ycc3csyh	928	13	in	in	IN
cord-270892-ycc3csyh	928	14	vitro	vitro	FW
cord-270892-ycc3csyh	928	15	Prevention	prevention	NN
cord-270892-ycc3csyh	928	16	of	of	IN
cord-270892-ycc3csyh	928	17	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	928	18	infection	infection	NN
cord-270892-ycc3csyh	928	19	in	in	IN
cord-270892-ycc3csyh	928	20	chimpanzees	chimpanzee	NNS
cord-270892-ycc3csyh	928	21	by	by	IN
cord-270892-ycc3csyh	928	22	soluble	soluble	JJ
cord-270892-ycc3csyh	928	23	intercellular	intercellular	JJ
cord-270892-ycc3csyh	928	24	adhesion	adhesion	NN
cord-270892-ycc3csyh	928	25	molecule-1	molecule-1	NNP
cord-270892-ycc3csyh	928	26	Efficacy	Efficacy	NNP
cord-270892-ycc3csyh	928	27	of	of	IN
cord-270892-ycc3csyh	928	28	tremacamra	tremacamra	NN
cord-270892-ycc3csyh	928	29	,	,	,
cord-270892-ycc3csyh	928	30	a	a	DT
cord-270892-ycc3csyh	928	31	soluble	soluble	JJ
cord-270892-ycc3csyh	928	32	intercellular	intercellular	JJ
cord-270892-ycc3csyh	928	33	adhesion	adhesion	NN
cord-270892-ycc3csyh	928	34	molecule	molecule	NN
cord-270892-ycc3csyh	928	35	1	1	CD
cord-270892-ycc3csyh	928	36	,	,	,
cord-270892-ycc3csyh	928	37	for	for	IN
cord-270892-ycc3csyh	928	38	experimental	experimental	JJ
cord-270892-ycc3csyh	928	39	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	928	40	infection	infection	NN
cord-270892-ycc3csyh	928	41	:	:	:
cord-270892-ycc3csyh	928	42	A	a	DT
cord-270892-ycc3csyh	928	43	randomized	randomized	JJ
cord-270892-ycc3csyh	928	44	clinical	clinical	JJ
cord-270892-ycc3csyh	928	45	trial	trial	NN
cord-270892-ycc3csyh	928	46	Inhibitors	Inhibitors	NNP
cord-270892-ycc3csyh	928	47	of	of	IN
cord-270892-ycc3csyh	928	48	picornavirus	picornavirus	NNP
cord-270892-ycc3csyh	928	49	replication	replication	NN
cord-270892-ycc3csyh	929	1	The	the	DT
cord-270892-ycc3csyh	929	2	structure	structure	NN
cord-270892-ycc3csyh	929	3	of	of	IN
cord-270892-ycc3csyh	929	4	antiviral	antiviral	JJ
cord-270892-ycc3csyh	929	5	agents	agent	NNS
cord-270892-ycc3csyh	929	6	that	that	WDT
cord-270892-ycc3csyh	929	7	inhibit	inhibit	VBP
cord-270892-ycc3csyh	929	8	uncoating	uncoate	VBG
cord-270892-ycc3csyh	929	9	when	when	WRB
cord-270892-ycc3csyh	929	10	complexed	complexe	VBN
cord-270892-ycc3csyh	929	11	with	with	IN
cord-270892-ycc3csyh	929	12	viral	viral	JJ
cord-270892-ycc3csyh	929	13	capsids	capsid	NNS
cord-270892-ycc3csyh	929	14	Structural	structural	JJ
cord-270892-ycc3csyh	929	15	and	and	CC
cord-270892-ycc3csyh	929	16	virological	virological	JJ
cord-270892-ycc3csyh	929	17	studies	study	NNS
cord-270892-ycc3csyh	929	18	of	of	IN
cord-270892-ycc3csyh	929	19	the	the	DT
cord-270892-ycc3csyh	929	20	stages	stage	NNS
cord-270892-ycc3csyh	929	21	of	of	IN
cord-270892-ycc3csyh	929	22	virus	virus	NN
cord-270892-ycc3csyh	929	23	replication	replication	NN
cord-270892-ycc3csyh	929	24	that	that	WDT
cord-270892-ycc3csyh	929	25	are	be	VBP
cord-270892-ycc3csyh	929	26	affected	affect	VBN
cord-270892-ycc3csyh	929	27	by	by	IN
cord-270892-ycc3csyh	929	28	antirhinovirus	antirhinovirus	NNP
cord-270892-ycc3csyh	929	29	compounds	compound	NNS
cord-270892-ycc3csyh	929	30	Structural	structural	JJ
cord-270892-ycc3csyh	929	31	analysis	analysis	NN
cord-270892-ycc3csyh	929	32	of	of	IN
cord-270892-ycc3csyh	929	33	antiviral	antiviral	JJ
cord-270892-ycc3csyh	929	34	agents	agent	NNS
cord-270892-ycc3csyh	929	35	that	that	WDT
cord-270892-ycc3csyh	929	36	interact	interact	VBP
cord-270892-ycc3csyh	929	37	with	with	IN
cord-270892-ycc3csyh	929	38	the	the	DT
cord-270892-ycc3csyh	929	39	capsid	capsid	NN
cord-270892-ycc3csyh	929	40	of	of	IN
cord-270892-ycc3csyh	929	41	human	human	JJ
cord-270892-ycc3csyh	929	42	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	929	43	Conformational	Conformational	NNP
cord-270892-ycc3csyh	929	44	change	change	NN
cord-270892-ycc3csyh	929	45	in	in	IN
cord-270892-ycc3csyh	929	46	the	the	DT
cord-270892-ycc3csyh	929	47	floor	floor	NN
cord-270892-ycc3csyh	929	48	of	of	IN
cord-270892-ycc3csyh	929	49	the	the	DT
cord-270892-ycc3csyh	929	50	human	human	JJ
cord-270892-ycc3csyh	929	51	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	929	52	canyon	canyon	NN
cord-270892-ycc3csyh	929	53	blocks	block	VBZ
cord-270892-ycc3csyh	929	54	adsorption	adsorption	NN
cord-270892-ycc3csyh	929	55	to	to	IN
cord-270892-ycc3csyh	929	56	HeLa	HeLa	NNP
cord-270892-ycc3csyh	929	57	cell	cell	NN
cord-270892-ycc3csyh	929	58	receptors	receptor	NNS
cord-270892-ycc3csyh	930	1	The	the	DT
cord-270892-ycc3csyh	930	2	site	site	NN
cord-270892-ycc3csyh	930	3	of	of	IN
cord-270892-ycc3csyh	930	4	attachment	attachment	NN
cord-270892-ycc3csyh	930	5	in	in	IN
cord-270892-ycc3csyh	930	6	human	human	JJ
cord-270892-ycc3csyh	930	7	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	930	8	14	14	CD
cord-270892-ycc3csyh	930	9	for	for	IN
cord-270892-ycc3csyh	930	10	antiviral	antiviral	JJ
cord-270892-ycc3csyh	930	11	agents	agent	NNS
cord-270892-ycc3csyh	930	12	that	that	WDT
cord-270892-ycc3csyh	930	13	inhibit	inhibit	VBP
cord-270892-ycc3csyh	930	14	uncoating	uncoate	VBG
cord-270892-ycc3csyh	930	15	A	a	DT
cord-270892-ycc3csyh	930	16	comparison	comparison	NN
cord-270892-ycc3csyh	930	17	of	of	IN
cord-270892-ycc3csyh	930	18	the	the	DT
cord-270892-ycc3csyh	930	19	anti	anti	JJ
cord-270892-ycc3csyh	930	20	-	-	JJ
cord-270892-ycc3csyh	930	21	rhinoviral	rhinoviral	JJ
cord-270892-ycc3csyh	930	22	drug	drug	NN
cord-270892-ycc3csyh	930	23	binding	bind	VBG
cord-270892-ycc3csyh	930	24	pocket	pocket	NN
cord-270892-ycc3csyh	930	25	in	in	IN
cord-270892-ycc3csyh	930	26	HRV14	HRV14	NNP
cord-270892-ycc3csyh	930	27	and	and	CC
cord-270892-ycc3csyh	930	28	HRV1A	HRV1A	NNP
cord-270892-ycc3csyh	930	29	Analysis	Analysis	NNP
cord-270892-ycc3csyh	930	30	of	of	IN
cord-270892-ycc3csyh	930	31	three	three	CD
cord-270892-ycc3csyh	930	32	structurally	structurally	RB
cord-270892-ycc3csyh	930	33	related	related	JJ
cord-270892-ycc3csyh	930	34	antiviral	antiviral	JJ
cord-270892-ycc3csyh	930	35	compounds	compound	NNS
cord-270892-ycc3csyh	930	36	in	in	IN
cord-270892-ycc3csyh	930	37	complex	complex	NN
cord-270892-ycc3csyh	930	38	with	with	IN
cord-270892-ycc3csyh	930	39	human	human	JJ
cord-270892-ycc3csyh	930	40	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	930	41	16	16	CD
cord-270892-ycc3csyh	930	42	Antiviral	Antiviral	NNP
cord-270892-ycc3csyh	930	43	capsid	capsid	RB
cord-270892-ycc3csyh	930	44	-	-	HYPH
cord-270892-ycc3csyh	930	45	binding	bind	VBG
cord-270892-ycc3csyh	930	46	compounds	compound	NNS
cord-270892-ycc3csyh	930	47	can	can	MD
cord-270892-ycc3csyh	930	48	inhibit	inhibit	VB
cord-270892-ycc3csyh	930	49	the	the	DT
cord-270892-ycc3csyh	930	50	adsorption	adsorption	NN
cord-270892-ycc3csyh	930	51	of	of	IN
cord-270892-ycc3csyh	930	52	minor	minor	JJ
cord-270892-ycc3csyh	930	53	receptor	receptor	NN
cord-270892-ycc3csyh	930	54	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	931	1	In	in	IN
cord-270892-ycc3csyh	931	2	vitro	vitro	FW
cord-270892-ycc3csyh	931	3	activity	activity	NN
cord-270892-ycc3csyh	931	4	of	of	IN
cord-270892-ycc3csyh	931	5	pleconaril	pleconaril	NNP
cord-270892-ycc3csyh	931	6	and	and	CC
cord-270892-ycc3csyh	931	7	AG7088	ag7088	VB
cord-270892-ycc3csyh	931	8	against	against	IN
cord-270892-ycc3csyh	931	9	selected	select	VBN
cord-270892-ycc3csyh	931	10	serotypes	serotype	NNS
cord-270892-ycc3csyh	931	11	and	and	CC
cord-270892-ycc3csyh	931	12	clinical	clinical	JJ
cord-270892-ycc3csyh	931	13	isolates	isolate	NNS
cord-270892-ycc3csyh	931	14	of	of	IN
cord-270892-ycc3csyh	931	15	human	human	JJ
cord-270892-ycc3csyh	931	16	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	931	17	Activity	Activity	NNP
cord-270892-ycc3csyh	931	18	of	of	IN
cord-270892-ycc3csyh	931	19	pleconaril	pleconaril	NNP
cord-270892-ycc3csyh	931	20	against	against	IN
cord-270892-ycc3csyh	931	21	enteroviruses	enteroviruses	NNP
cord-270892-ycc3csyh	931	22	Susceptibility	Susceptibility	NNP
cord-270892-ycc3csyh	931	23	of	of	IN
cord-270892-ycc3csyh	931	24	coxsackievirus	coxsackievirus	NNP
cord-270892-ycc3csyh	931	25	B3	B3	NNP
cord-270892-ycc3csyh	931	26	laboratory	laboratory	NN
cord-270892-ycc3csyh	931	27	strains	strain	NNS
cord-270892-ycc3csyh	931	28	and	and	CC
cord-270892-ycc3csyh	931	29	clinical	clinical	JJ
cord-270892-ycc3csyh	931	30	isolates	isolate	NNS
cord-270892-ycc3csyh	931	31	to	to	IN
cord-270892-ycc3csyh	931	32	the	the	DT
cord-270892-ycc3csyh	931	33	capsid	capsid	NN
cord-270892-ycc3csyh	931	34	function	function	NN
cord-270892-ycc3csyh	932	1	inhibitor	inhibitor	NNP
cord-270892-ycc3csyh	932	2	pleconaril	pleconaril	NNP
cord-270892-ycc3csyh	933	1	:	:	:
cord-270892-ycc3csyh	933	2	Antiviral	antiviral	JJ
cord-270892-ycc3csyh	933	3	studies	study	NNS
cord-270892-ycc3csyh	933	4	with	with	IN
cord-270892-ycc3csyh	933	5	virus	virus	NN
cord-270892-ycc3csyh	933	6	chimeras	chimera	NNS
cord-270892-ycc3csyh	933	7	demonstrate	demonstrate	VBP
cord-270892-ycc3csyh	933	8	the	the	DT
cord-270892-ycc3csyh	933	9	crucial	crucial	JJ
cord-270892-ycc3csyh	933	10	role	role	NN
cord-270892-ycc3csyh	933	11	of	of	IN
cord-270892-ycc3csyh	933	12	amino	amino	NN
cord-270892-ycc3csyh	933	13	acid	acid	NN
cord-270892-ycc3csyh	933	14	1092	1092	CD
cord-270892-ycc3csyh	933	15	in	in	IN
cord-270892-ycc3csyh	933	16	treatment	treatment	NN
cord-270892-ycc3csyh	934	1	In	in	IN
cord-270892-ycc3csyh	934	2	vitro	vitro	FW
cord-270892-ycc3csyh	934	3	activity	activity	NN
cord-270892-ycc3csyh	934	4	of	of	IN
cord-270892-ycc3csyh	934	5	R	R	NNP
cord-270892-ycc3csyh	934	6	61837	61837	CD
cord-270892-ycc3csyh	934	7	,	,	,
cord-270892-ycc3csyh	934	8	a	a	DT
cord-270892-ycc3csyh	934	9	new	new	JJ
cord-270892-ycc3csyh	934	10	antirhinovirus	antirhinovirus	NNP
cord-270892-ycc3csyh	934	11	compound	compound	NN
cord-270892-ycc3csyh	935	1	In	in	IN
cord-270892-ycc3csyh	935	2	vitro	vitro	FW
cord-270892-ycc3csyh	935	3	activity	activity	NN
cord-270892-ycc3csyh	935	4	of	of	IN
cord-270892-ycc3csyh	935	5	pirodavir	pirodavir	NNP
cord-270892-ycc3csyh	935	6	(	(	-LRB-
cord-270892-ycc3csyh	935	7	R	R	NNP
cord-270892-ycc3csyh	935	8	77975	77975	CD
cord-270892-ycc3csyh	935	9	)	)	-RRB-
cord-270892-ycc3csyh	935	10	,	,	,
cord-270892-ycc3csyh	935	11	a	a	DT
cord-270892-ycc3csyh	935	12	substituted	substitute	VBN
cord-270892-ycc3csyh	935	13	phenoxy	phenoxy	NNP
cord-270892-ycc3csyh	935	14	-	-	HYPH
cord-270892-ycc3csyh	935	15	pyridazinamine	pyridazinamine	NNP
cord-270892-ycc3csyh	935	16	with	with	IN
cord-270892-ycc3csyh	935	17	broad	broad	JJ
cord-270892-ycc3csyh	935	18	-	-	HYPH
cord-270892-ycc3csyh	935	19	spectrum	spectrum	NN
cord-270892-ycc3csyh	935	20	antipicornaviral	antipicornaviral	NNP
cord-270892-ycc3csyh	935	21	activity	activity	NN
cord-270892-ycc3csyh	935	22	Quantitative	Quantitative	NNP
cord-270892-ycc3csyh	935	23	structure	structure	NN
cord-270892-ycc3csyh	935	24	-	-	HYPH
cord-270892-ycc3csyh	935	25	activity	activity	NN
cord-270892-ycc3csyh	935	26	relationship	relationship	NN
cord-270892-ycc3csyh	935	27	studies	study	NNS
cord-270892-ycc3csyh	935	28	of	of	IN
cord-270892-ycc3csyh	935	29	[	[	-LRB-
cord-270892-ycc3csyh	935	30	(	(	-LRB-
cord-270892-ycc3csyh	935	31	biphenyloxy)-propyl]isoxazole	biphenyloxy)-propyl]isoxazole	JJ
cord-270892-ycc3csyh	935	32	derivatives	derivative	NNS
cord-270892-ycc3csyh	935	33	.	.	.
cord-270892-ycc3csyh	936	1	Inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	936	2	of	of	IN
cord-270892-ycc3csyh	936	3	human	human	JJ
cord-270892-ycc3csyh	936	4	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	936	5	2	2	CD
cord-270892-ycc3csyh	936	6	replication	replication	NN
cord-270892-ycc3csyh	936	7	SCH	SCH	NNP
cord-270892-ycc3csyh	936	8	48973	48973	CD
cord-270892-ycc3csyh	936	9	:	:	:
cord-270892-ycc3csyh	936	10	A	a	DT
cord-270892-ycc3csyh	936	11	potent	potent	JJ
cord-270892-ycc3csyh	936	12	,	,	,
cord-270892-ycc3csyh	936	13	broad	broad	JJ
cord-270892-ycc3csyh	936	14	-	-	HYPH
cord-270892-ycc3csyh	936	15	spectrum	spectrum	NN
cord-270892-ycc3csyh	936	16	,	,	,
cord-270892-ycc3csyh	936	17	antienterovirus	antienterovirus	NNP
cord-270892-ycc3csyh	936	18	compound	compound	NNP
cord-270892-ycc3csyh	936	19	Antipicornavirus	Antipicornavirus	NNP
cord-270892-ycc3csyh	936	20	activity	activity	NN
cord-270892-ycc3csyh	936	21	of	of	IN
cord-270892-ycc3csyh	936	22	SCH	SCH	NNP
cord-270892-ycc3csyh	936	23	47802	47802	CD
cord-270892-ycc3csyh	936	24	and	and	CC
cord-270892-ycc3csyh	936	25	analogs	analog	NNS
cord-270892-ycc3csyh	936	26	:	:	:
cord-270892-ycc3csyh	936	27	In	in	IN
cord-270892-ycc3csyh	936	28	vitro	vitro	FW
cord-270892-ycc3csyh	936	29	and	and	CC
cord-270892-ycc3csyh	936	30	in	in	IN
cord-270892-ycc3csyh	936	31	vivo	vivo	NNP
cord-270892-ycc3csyh	936	32	studies	study	NNS
cord-270892-ycc3csyh	936	33	SCH	SCH	NNP
cord-270892-ycc3csyh	936	34	38057	38057	CD
cord-270892-ycc3csyh	936	35	:	:	:
cord-270892-ycc3csyh	936	36	A	a	DT
cord-270892-ycc3csyh	936	37	picornavirus	picornavirus	NN
cord-270892-ycc3csyh	936	38	capsid	capsid	RB
cord-270892-ycc3csyh	936	39	-	-	HYPH
cord-270892-ycc3csyh	936	40	binding	bind	VBG
cord-270892-ycc3csyh	936	41	molecule	molecule	NN
cord-270892-ycc3csyh	936	42	with	with	IN
cord-270892-ycc3csyh	936	43	antiviral	antiviral	JJ
cord-270892-ycc3csyh	936	44	activity	activity	NN
cord-270892-ycc3csyh	936	45	after	after	IN
cord-270892-ycc3csyh	936	46	the	the	DT
cord-270892-ycc3csyh	936	47	initial	initial	JJ
cord-270892-ycc3csyh	936	48	stage	stage	NN
cord-270892-ycc3csyh	936	49	of	of	IN
cord-270892-ycc3csyh	936	50	viral	viral	JJ
cord-270892-ycc3csyh	936	51	uncoating	uncoate	VBG
cord-270892-ycc3csyh	936	52	Direct	direct	JJ
cord-270892-ycc3csyh	936	53	and	and	CC
cord-270892-ycc3csyh	936	54	specific	specific	JJ
cord-270892-ycc3csyh	936	55	inactivation	inactivation	NN
cord-270892-ycc3csyh	936	56	of	of	IN
cord-270892-ycc3csyh	936	57	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	936	58	by	by	IN
cord-270892-ycc3csyh	936	59	chalcone	chalcone	NNP
cord-270892-ycc3csyh	936	60	Ro	Ro	NNP
cord-270892-ycc3csyh	936	61	09	09	CD
cord-270892-ycc3csyh	936	62	-	-	HYPH
cord-270892-ycc3csyh	936	63	0410	0410	CD
cord-270892-ycc3csyh	936	64	Comparative	Comparative	NNP
cord-270892-ycc3csyh	936	65	studies	study	NNS
cord-270892-ycc3csyh	936	66	on	on	IN
cord-270892-ycc3csyh	936	67	the	the	DT
cord-270892-ycc3csyh	936	68	antirhinovirus	antirhinovirus	JJ
cord-270892-ycc3csyh	936	69	activity	activity	NN
cord-270892-ycc3csyh	936	70	and	and	CC
cord-270892-ycc3csyh	936	71	the	the	DT
cord-270892-ycc3csyh	936	72	mode	mode	NN
cord-270892-ycc3csyh	936	73	of	of	IN
cord-270892-ycc3csyh	936	74	action	action	NN
cord-270892-ycc3csyh	936	75	of	of	IN
cord-270892-ycc3csyh	936	76	the	the	DT
cord-270892-ycc3csyh	936	77	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	936	78	capsid	capsid	RB
cord-270892-ycc3csyh	936	79	-	-	HYPH
cord-270892-ycc3csyh	936	80	binding	bind	VBG
cord-270892-ycc3csyh	936	81	agents	agent	NNS
cord-270892-ycc3csyh	936	82	,	,	,
cord-270892-ycc3csyh	936	83	chalcone	chalcone	NN
cord-270892-ycc3csyh	936	84	amides	amide	NNS
cord-270892-ycc3csyh	936	85	4	4	CD
cord-270892-ycc3csyh	936	86	0	0	CD
cord-270892-ycc3csyh	936	87	,	,	,
cord-270892-ycc3csyh	936	88	6-Dichloroflavan	6-Dichloroflavan	NNP
cord-270892-ycc3csyh	936	89	(	(	-LRB-
cord-270892-ycc3csyh	936	90	BW683C	BW683C	NNP
cord-270892-ycc3csyh	936	91	)	)	-RRB-
cord-270892-ycc3csyh	936	92	,	,	,
cord-270892-ycc3csyh	936	93	a	a	DT
cord-270892-ycc3csyh	936	94	new	new	JJ
cord-270892-ycc3csyh	936	95	anti	anti	JJ
cord-270892-ycc3csyh	936	96	-	-	JJ
cord-270892-ycc3csyh	936	97	rhinovirus	rhinovirus	JJ
cord-270892-ycc3csyh	936	98	compound	compound	NN
cord-270892-ycc3csyh	936	99	3,4-Dihydro-2-phenyl-2H	3,4-dihydro-2-phenyl-2h	CD
cord-270892-ycc3csyh	936	100	-	-	:
cord-270892-ycc3csyh	936	101	pyrano[2,3-b]pyridines	pyrano[2,3-b]pyridines	NNPS
cord-270892-ycc3csyh	936	102	with	with	IN
cord-270892-ycc3csyh	936	103	potent	potent	JJ
cord-270892-ycc3csyh	936	104	antirhinovirus	antirhinovirus	JJ
cord-270892-ycc3csyh	936	105	activity	activity	NN
cord-270892-ycc3csyh	936	106	Antipicornavirus	Antipicornavirus	NNP
cord-270892-ycc3csyh	936	107	activity	activity	NN
cord-270892-ycc3csyh	936	108	of	of	IN
cord-270892-ycc3csyh	936	109	substituted	substitute	VBN
cord-270892-ycc3csyh	936	110	phenoxybenzenes	phenoxybenzene	NNS
cord-270892-ycc3csyh	936	111	and	and	CC
cord-270892-ycc3csyh	936	112	phenoxypyridines	phenoxypyridines	NNPS
cord-270892-ycc3csyh	936	113	Activity	Activity	NNP
cord-270892-ycc3csyh	936	114	of	of	IN
cord-270892-ycc3csyh	936	115	2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile	2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile	CD
cord-270892-ycc3csyh	936	116	(	(	-LRB-
cord-270892-ycc3csyh	936	117	MDL-860	mdl-860	UH
cord-270892-ycc3csyh	936	118	)	)	-RRB-
cord-270892-ycc3csyh	936	119	against	against	IN
cord-270892-ycc3csyh	936	120	picornaviruses	picornaviruses	NNP
cord-270892-ycc3csyh	936	121	in	in	IN
cord-270892-ycc3csyh	936	122	vitro	vitro	FW
cord-270892-ycc3csyh	936	123	Application	Application	NNP
cord-270892-ycc3csyh	936	124	of	of	IN
cord-270892-ycc3csyh	936	125	crystallography	crystallography	NN
cord-270892-ycc3csyh	936	126	to	to	IN
cord-270892-ycc3csyh	936	127	the	the	DT
cord-270892-ycc3csyh	936	128	design	design	NN
cord-270892-ycc3csyh	936	129	of	of	IN
cord-270892-ycc3csyh	936	130	antiviral	antiviral	JJ
cord-270892-ycc3csyh	936	131	agents	agent	NNS
cord-270892-ycc3csyh	936	132	Clinical	clinical	JJ
cord-270892-ycc3csyh	936	133	activity	activity	NN
cord-270892-ycc3csyh	936	134	of	of	IN
cord-270892-ycc3csyh	936	135	pleconaril	pleconaril	NN
cord-270892-ycc3csyh	936	136	in	in	IN
cord-270892-ycc3csyh	936	137	an	an	DT
cord-270892-ycc3csyh	936	138	experimentally	experimentally	RB
cord-270892-ycc3csyh	936	139	induced	induce	VBN
cord-270892-ycc3csyh	936	140	coxsackievirus	coxsackievirus	NN
cord-270892-ycc3csyh	936	141	A21	A21	NNP
cord-270892-ycc3csyh	936	142	respiratory	respiratory	JJ
cord-270892-ycc3csyh	936	143	infection	infection	NN
cord-270892-ycc3csyh	936	144	Oral	oral	JJ
cord-270892-ycc3csyh	936	145	pleconaril	pleconaril	JJ
cord-270892-ycc3csyh	936	146	treatment	treatment	NN
cord-270892-ycc3csyh	936	147	of	of	IN
cord-270892-ycc3csyh	936	148	picornavirus	picornavirus	NN
cord-270892-ycc3csyh	936	149	-	-	HYPH
cord-270892-ycc3csyh	936	150	associated	associate	VBN
cord-270892-ycc3csyh	936	151	viral	viral	JJ
cord-270892-ycc3csyh	936	152	respiratory	respiratory	JJ
cord-270892-ycc3csyh	936	153	illness	illness	NN
cord-270892-ycc3csyh	936	154	in	in	IN
cord-270892-ycc3csyh	936	155	adults	adult	NNS
cord-270892-ycc3csyh	936	156	:	:	:
cord-270892-ycc3csyh	937	1	Efficacy	efficacy	NN
cord-270892-ycc3csyh	937	2	and	and	CC
cord-270892-ycc3csyh	937	3	tolerability	tolerability	NN
cord-270892-ycc3csyh	937	4	in	in	IN
cord-270892-ycc3csyh	937	5	phase	phase	NN
cord-270892-ycc3csyh	937	6	II	ii	CD
cord-270892-ycc3csyh	937	7	clinical	clinical	JJ
cord-270892-ycc3csyh	937	8	trials	trial	NNS
cord-270892-ycc3csyh	937	9	Efficacy	Efficacy	NNP
cord-270892-ycc3csyh	937	10	and	and	CC
cord-270892-ycc3csyh	937	11	safety	safety	NN
cord-270892-ycc3csyh	937	12	of	of	IN
cord-270892-ycc3csyh	937	13	oral	oral	JJ
cord-270892-ycc3csyh	937	14	pleconaril	pleconaril	NN
cord-270892-ycc3csyh	937	15	for	for	IN
cord-270892-ycc3csyh	937	16	treatment	treatment	NN
cord-270892-ycc3csyh	937	17	of	of	IN
cord-270892-ycc3csyh	937	18	colds	cold	NNS
cord-270892-ycc3csyh	937	19	due	due	JJ
cord-270892-ycc3csyh	937	20	to	to	IN
cord-270892-ycc3csyh	937	21	picornaviruses	picornavirus	NNS
cord-270892-ycc3csyh	937	22	in	in	IN
cord-270892-ycc3csyh	937	23	adults	adult	NNS
cord-270892-ycc3csyh	937	24	:	:	:
cord-270892-ycc3csyh	937	25	Results	result	NNS
cord-270892-ycc3csyh	937	26	of	of	IN
cord-270892-ycc3csyh	937	27	2	2	CD
cord-270892-ycc3csyh	937	28	double	double	JJ
cord-270892-ycc3csyh	937	29	-	-	HYPH
cord-270892-ycc3csyh	937	30	blind	blind	JJ
cord-270892-ycc3csyh	937	31	,	,	,
cord-270892-ycc3csyh	937	32	randomized	randomized	JJ
cord-270892-ycc3csyh	937	33	,	,	,
cord-270892-ycc3csyh	937	34	placebo	placebo	NN
cord-270892-ycc3csyh	937	35	-	-	HYPH
cord-270892-ycc3csyh	937	36	controlled	control	VBN
cord-270892-ycc3csyh	937	37	trials	trial	NNS
cord-270892-ycc3csyh	937	38	Relationship	relationship	NN
cord-270892-ycc3csyh	937	39	of	of	IN
cord-270892-ycc3csyh	937	40	pleconaril	pleconaril	NNP
cord-270892-ycc3csyh	937	41	susceptibility	susceptibility	NN
cord-270892-ycc3csyh	937	42	and	and	CC
cord-270892-ycc3csyh	937	43	clinical	clinical	JJ
cord-270892-ycc3csyh	937	44	outcomes	outcome	NNS
cord-270892-ycc3csyh	937	45	in	in	IN
cord-270892-ycc3csyh	937	46	treatment	treatment	NN
cord-270892-ycc3csyh	937	47	of	of	IN
cord-270892-ycc3csyh	937	48	common	common	JJ
cord-270892-ycc3csyh	937	49	colds	cold	NNS
cord-270892-ycc3csyh	937	50	caused	cause	VBN
cord-270892-ycc3csyh	937	51	by	by	IN
cord-270892-ycc3csyh	937	52	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	938	1	The	the	DT
cord-270892-ycc3csyh	938	2	effect	effect	NN
cord-270892-ycc3csyh	938	3	of	of	IN
cord-270892-ycc3csyh	938	4	oral	oral	JJ
cord-270892-ycc3csyh	938	5	pleconaril	pleconaril	NN
cord-270892-ycc3csyh	938	6	on	on	IN
cord-270892-ycc3csyh	938	7	hepatic	hepatic	JJ
cord-270892-ycc3csyh	938	8	cytochrome	cytochrome	NN
cord-270892-ycc3csyh	938	9	P450	p450	JJ
cord-270892-ycc3csyh	938	10	3A	3a	NN
cord-270892-ycc3csyh	938	11	activity	activity	NN
cord-270892-ycc3csyh	938	12	in	in	IN
cord-270892-ycc3csyh	938	13	healthy	healthy	JJ
cord-270892-ycc3csyh	938	14	adults	adult	NNS
cord-270892-ycc3csyh	938	15	using	use	VBG
cord-270892-ycc3csyh	938	16	intravenous	intravenous	JJ
cord-270892-ycc3csyh	938	17	midazolam	midazolam	NN
cord-270892-ycc3csyh	938	18	as	as	IN
cord-270892-ycc3csyh	938	19	a	a	DT
cord-270892-ycc3csyh	938	20	probe	probe	NN
cord-270892-ycc3csyh	938	21	Safety	safety	NN
cord-270892-ycc3csyh	938	22	and	and	CC
cord-270892-ycc3csyh	938	23	efficacy	efficacy	NN
cord-270892-ycc3csyh	938	24	of	of	IN
cord-270892-ycc3csyh	938	25	intranasal	intranasal	NN
cord-270892-ycc3csyh	938	26	pirodavir	pirodavir	NNP
cord-270892-ycc3csyh	938	27	(	(	-LRB-
cord-270892-ycc3csyh	938	28	R77975	R77975	NNP
cord-270892-ycc3csyh	938	29	)	)	-RRB-
cord-270892-ycc3csyh	938	30	in	in	IN
cord-270892-ycc3csyh	938	31	experimental	experimental	JJ
cord-270892-ycc3csyh	938	32	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	938	33	infection	infection	NN
cord-270892-ycc3csyh	938	34	Inhibition	Inhibition	NNP
cord-270892-ycc3csyh	938	35	of	of	IN
cord-270892-ycc3csyh	938	36	polyprotein	polyprotein	JJ
cord-270892-ycc3csyh	938	37	processing	processing	NN
cord-270892-ycc3csyh	938	38	and	and	CC
cord-270892-ycc3csyh	938	39	RNA	RNA	NNP
cord-270892-ycc3csyh	938	40	replication	replication	NN
cord-270892-ycc3csyh	938	41	of	of	IN
cord-270892-ycc3csyh	938	42	human	human	JJ
cord-270892-ycc3csyh	938	43	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	938	44	by	by	IN
cord-270892-ycc3csyh	938	45	pyrrolidine	pyrrolidine	NNP
cord-270892-ycc3csyh	938	46	dithiocarbamate	dithiocarbamate	NNP
cord-270892-ycc3csyh	938	47	involves	involve	VBZ
cord-270892-ycc3csyh	938	48	metal	metal	NN
cord-270892-ycc3csyh	938	49	ions	ion	NNS
cord-270892-ycc3csyh	939	1	Nitric	nitric	NN
cord-270892-ycc3csyh	939	2	oxide	oxide	NN
cord-270892-ycc3csyh	939	3	inhibits	inhibit	VBZ
cord-270892-ycc3csyh	939	4	dystrophin	dystrophin	NN
cord-270892-ycc3csyh	939	5	proteolysis	proteolysis	NN
cord-270892-ycc3csyh	939	6	by	by	IN
cord-270892-ycc3csyh	939	7	coxsackieviral	coxsackieviral	JJ
cord-270892-ycc3csyh	939	8	protease	protease	NN
cord-270892-ycc3csyh	939	9	2A	2a	CD
cord-270892-ycc3csyh	939	10	through	through	IN
cord-270892-ycc3csyh	939	11	S	s	NN
cord-270892-ycc3csyh	939	12	-	-	HYPH
cord-270892-ycc3csyh	939	13	nitrosylation	nitrosylation	NN
cord-270892-ycc3csyh	939	14	:	:	:
cord-270892-ycc3csyh	939	15	A	a	DT
cord-270892-ycc3csyh	939	16	protective	protective	JJ
cord-270892-ycc3csyh	939	17	mechanism	mechanism	NN
cord-270892-ycc3csyh	939	18	against	against	IN
cord-270892-ycc3csyh	939	19	enteroviral	enteroviral	JJ
cord-270892-ycc3csyh	939	20	cardiomyopathy	cardiomyopathy	NN
cord-270892-ycc3csyh	940	1	An	an	DT
cord-270892-ycc3csyh	940	2	antiviral	antiviral	JJ
cord-270892-ycc3csyh	940	3	mechanism	mechanism	NN
cord-270892-ycc3csyh	940	4	of	of	IN
cord-270892-ycc3csyh	940	5	nitric	nitric	NN
cord-270892-ycc3csyh	940	6	oxide	oxide	NN
cord-270892-ycc3csyh	940	7	:	:	:
cord-270892-ycc3csyh	941	1	Inhibition	inhibition	NN
cord-270892-ycc3csyh	941	2	of	of	IN
cord-270892-ycc3csyh	941	3	a	a	DT
cord-270892-ycc3csyh	941	4	viral	viral	JJ
cord-270892-ycc3csyh	941	5	protease	protease	NN
cord-270892-ycc3csyh	941	6	Nitric	nitric	NN
cord-270892-ycc3csyh	941	7	oxide	oxide	NN
cord-270892-ycc3csyh	941	8	inhibition	inhibition	NN
cord-270892-ycc3csyh	941	9	of	of	IN
cord-270892-ycc3csyh	941	10	coxsackievirus	coxsackievirus	NNP
cord-270892-ycc3csyh	941	11	replication	replication	NN
cord-270892-ycc3csyh	941	12	in	in	IN
cord-270892-ycc3csyh	941	13	vitro	vitro	FW
cord-270892-ycc3csyh	942	1	Nitric	nitric	NN
cord-270892-ycc3csyh	942	2	oxide	oxide	NN
cord-270892-ycc3csyh	942	3	donors	donor	NNS
cord-270892-ycc3csyh	942	4	inhibit	inhibit	VBP
cord-270892-ycc3csyh	942	5	the	the	DT
cord-270892-ycc3csyh	942	6	coxsackievirus	coxsackievirus	NNP
cord-270892-ycc3csyh	942	7	B3	B3	NNP
cord-270892-ycc3csyh	942	8	proteinases	proteinases	NNP
cord-270892-ycc3csyh	942	9	2A	2A	NNP
cord-270892-ycc3csyh	942	10	and	and	CC
cord-270892-ycc3csyh	942	11	3C	3c	NN
cord-270892-ycc3csyh	942	12	in	in	IN
cord-270892-ycc3csyh	942	13	vitro	vitro	FW
cord-270892-ycc3csyh	942	14	,	,	,
cord-270892-ycc3csyh	942	15	virus	virus	NN
cord-270892-ycc3csyh	942	16	production	production	NN
cord-270892-ycc3csyh	942	17	in	in	IN
cord-270892-ycc3csyh	942	18	cells	cell	NNS
cord-270892-ycc3csyh	942	19	,	,	,
cord-270892-ycc3csyh	942	20	and	and	CC
cord-270892-ycc3csyh	942	21	signs	sign	NNS
cord-270892-ycc3csyh	942	22	of	of	IN
cord-270892-ycc3csyh	942	23	myocarditis	myocarditis	NN
cord-270892-ycc3csyh	942	24	in	in	IN
cord-270892-ycc3csyh	942	25	virus	virus	NN
cord-270892-ycc3csyh	942	26	-	-	HYPH
cord-270892-ycc3csyh	942	27	infected	infect	VBN
cord-270892-ycc3csyh	942	28	mice	mouse	NNS
cord-270892-ycc3csyh	942	29	Effect	effect	NN
cord-270892-ycc3csyh	942	30	of	of	IN
cord-270892-ycc3csyh	942	31	nitric	nitric	JJ
cord-270892-ycc3csyh	942	32	oxide	oxide	NN
cord-270892-ycc3csyh	942	33	on	on	IN
cord-270892-ycc3csyh	942	34	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	942	35	replication	replication	NN
cord-270892-ycc3csyh	942	36	and	and	CC
cord-270892-ycc3csyh	942	37	virus	virus	NN
cord-270892-ycc3csyh	942	38	-	-	HYPH
cord-270892-ycc3csyh	942	39	induced	induce	VBN
cord-270892-ycc3csyh	943	1	interleukin-8	interleukin-8	NNP
cord-270892-ycc3csyh	944	1	elaboration	elaboration	NN
cord-270892-ycc3csyh	945	1	Inhibition	inhibition	NN
cord-270892-ycc3csyh	945	2	of	of	IN
cord-270892-ycc3csyh	945	3	proteolytic	proteolytic	JJ
cord-270892-ycc3csyh	945	4	activity	activity	NN
cord-270892-ycc3csyh	945	5	of	of	IN
cord-270892-ycc3csyh	945	6	poliovirus	poliovirus	NN
cord-270892-ycc3csyh	945	7	and	and	CC
cord-270892-ycc3csyh	945	8	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	945	9	2A	2a	CD
cord-270892-ycc3csyh	945	10	proteinases	proteinase	NNS
cord-270892-ycc3csyh	945	11	by	by	IN
cord-270892-ycc3csyh	945	12	elastase	elastase	NN
cord-270892-ycc3csyh	945	13	-	-	HYPH
cord-270892-ycc3csyh	945	14	specific	specific	JJ
cord-270892-ycc3csyh	945	15	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	946	1	An	an	DT
cord-270892-ycc3csyh	946	2	antiviral	antiviral	JJ
cord-270892-ycc3csyh	946	3	peptide	peptide	NN
cord-270892-ycc3csyh	946	4	inhibitor	inhibitor	NN
cord-270892-ycc3csyh	946	5	that	that	WDT
cord-270892-ycc3csyh	946	6	is	be	VBZ
cord-270892-ycc3csyh	946	7	active	active	JJ
cord-270892-ycc3csyh	946	8	against	against	IN
cord-270892-ycc3csyh	946	9	picornavirus	picornavirus	NNP
cord-270892-ycc3csyh	946	10	2A	2A	NNP
cord-270892-ycc3csyh	946	11	proteinases	proteinases	NNPS
cord-270892-ycc3csyh	946	12	but	but	CC
cord-270892-ycc3csyh	946	13	not	not	RB
cord-270892-ycc3csyh	946	14	cellular	cellular	JJ
cord-270892-ycc3csyh	946	15	caspases	caspase	NNS
cord-270892-ycc3csyh	946	16	Antiviral	antiviral	JJ
cord-270892-ycc3csyh	946	17	activity	activity	NN
cord-270892-ycc3csyh	946	18	of	of	IN
cord-270892-ycc3csyh	946	19	caspase	caspase	NN
cord-270892-ycc3csyh	946	20	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	946	21	:	:	:
cord-270892-ycc3csyh	947	1	Effect	effect	NN
cord-270892-ycc3csyh	947	2	on	on	IN
cord-270892-ycc3csyh	947	3	picornaviral	picornaviral	JJ
cord-270892-ycc3csyh	947	4	2A	2A	NNP
cord-270892-ycc3csyh	947	5	proteinase	proteinase	NNP
cord-270892-ycc3csyh	947	6	Dual	dual	JJ
cord-270892-ycc3csyh	947	7	inhibition	inhibition	NN
cord-270892-ycc3csyh	947	8	of	of	IN
cord-270892-ycc3csyh	947	9	human	human	JJ
cord-270892-ycc3csyh	947	10	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	947	11	2A	2A	NNP
cord-270892-ycc3csyh	947	12	and	and	CC
cord-270892-ycc3csyh	947	13	3C	3c	NN
cord-270892-ycc3csyh	947	14	proteases	protease	NNS
cord-270892-ycc3csyh	947	15	by	by	IN
cord-270892-ycc3csyh	947	16	homophthalimides	homophthalimides	NNP
cord-270892-ycc3csyh	947	17	Structure	Structure	NNP
cord-270892-ycc3csyh	947	18	of	of	IN
cord-270892-ycc3csyh	947	19	human	human	JJ
cord-270892-ycc3csyh	947	20	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	947	21	3C	3C	NNP
cord-270892-ycc3csyh	947	22	protease	protease	NNP
cord-270892-ycc3csyh	947	23	reveals	reveal	VBZ
cord-270892-ycc3csyh	947	24	a	a	DT
cord-270892-ycc3csyh	947	25	trypsin	trypsin	NN
cord-270892-ycc3csyh	947	26	-	-	HYPH
cord-270892-ycc3csyh	947	27	like	like	JJ
cord-270892-ycc3csyh	947	28	polypeptide	polypeptide	NN
cord-270892-ycc3csyh	947	29	fold	fold	VBG
cord-270892-ycc3csyh	947	30	,	,	,
cord-270892-ycc3csyh	947	31	RNA	rna	NN
cord-270892-ycc3csyh	947	32	-	-	HYPH
cord-270892-ycc3csyh	947	33	binding	bind	VBG
cord-270892-ycc3csyh	947	34	site	site	NN
cord-270892-ycc3csyh	947	35	,	,	,
cord-270892-ycc3csyh	947	36	and	and	CC
cord-270892-ycc3csyh	947	37	means	mean	VBZ
cord-270892-ycc3csyh	947	38	for	for	IN
cord-270892-ycc3csyh	947	39	cleaving	cleave	VBG
cord-270892-ycc3csyh	947	40	precursor	precursor	NN
cord-270892-ycc3csyh	947	41	polyprotein	polyprotein	NNP
cord-270892-ycc3csyh	947	42	Individual	individual	JJ
cord-270892-ycc3csyh	947	43	and	and	CC
cord-270892-ycc3csyh	947	44	common	common	JJ
cord-270892-ycc3csyh	947	45	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	947	46	of	of	IN
cord-270892-ycc3csyh	947	47	coronavirus	coronavirus	NN
cord-270892-ycc3csyh	947	48	and	and	CC
cord-270892-ycc3csyh	947	49	picornavirus	picornavirus	NN
cord-270892-ycc3csyh	947	50	main	main	JJ
cord-270892-ycc3csyh	947	51	proteases	protease	NNS
cord-270892-ycc3csyh	947	52	Structure	structure	NN
cord-270892-ycc3csyh	947	53	-	-	HYPH
cord-270892-ycc3csyh	947	54	assisted	assist	VBN
cord-270892-ycc3csyh	947	55	design	design	NN
cord-270892-ycc3csyh	947	56	of	of	IN
cord-270892-ycc3csyh	947	57	mechanism	mechanism	NN
cord-270892-ycc3csyh	947	58	-	-	HYPH
cord-270892-ycc3csyh	947	59	based	base	VBN
cord-270892-ycc3csyh	947	60	irreversible	irreversible	JJ
cord-270892-ycc3csyh	947	61	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	947	62	of	of	IN
cord-270892-ycc3csyh	947	63	human	human	JJ
cord-270892-ycc3csyh	947	64	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	947	65	3C	3C	NNP
cord-270892-ycc3csyh	947	66	protease	protease	NN
cord-270892-ycc3csyh	947	67	with	with	IN
cord-270892-ycc3csyh	947	68	potent	potent	JJ
cord-270892-ycc3csyh	947	69	antiviral	antiviral	JJ
cord-270892-ycc3csyh	947	70	activity	activity	NN
cord-270892-ycc3csyh	947	71	against	against	IN
cord-270892-ycc3csyh	947	72	multiple	multiple	JJ
cord-270892-ycc3csyh	947	73	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	947	74	serotypes	serotype	NNS
cord-270892-ycc3csyh	947	75	New	new	JJ
cord-270892-ycc3csyh	947	76	anti	anti	JJ
cord-270892-ycc3csyh	947	77	-	-	JJ
cord-270892-ycc3csyh	947	78	viral	viral	JJ
cord-270892-ycc3csyh	947	79	drugs	drug	NNS
cord-270892-ycc3csyh	947	80	for	for	IN
cord-270892-ycc3csyh	947	81	the	the	DT
cord-270892-ycc3csyh	947	82	treatment	treatment	NN
cord-270892-ycc3csyh	947	83	of	of	IN
cord-270892-ycc3csyh	947	84	the	the	DT
cord-270892-ycc3csyh	947	85	common	common	JJ
cord-270892-ycc3csyh	947	86	cold	cold	JJ
cord-270892-ycc3csyh	947	87	Structure	structure	NN
cord-270892-ycc3csyh	947	88	-	-	HYPH
cord-270892-ycc3csyh	947	89	based	base	VBN
cord-270892-ycc3csyh	947	90	design	design	NN
cord-270892-ycc3csyh	947	91	,	,	,
cord-270892-ycc3csyh	947	92	synthesis	synthesis	NN
cord-270892-ycc3csyh	947	93	,	,	,
cord-270892-ycc3csyh	947	94	and	and	CC
cord-270892-ycc3csyh	947	95	biological	biological	JJ
cord-270892-ycc3csyh	947	96	evaluation	evaluation	NN
cord-270892-ycc3csyh	947	97	of	of	IN
cord-270892-ycc3csyh	947	98	irreversible	irreversible	JJ
cord-270892-ycc3csyh	947	99	human	human	JJ
cord-270892-ycc3csyh	947	100	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	947	101	3C	3C	NNP
cord-270892-ycc3csyh	947	102	protease	protease	NN
cord-270892-ycc3csyh	947	103	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	947	104	.	.	.
cord-270892-ycc3csyh	948	1	1	1	LS
cord-270892-ycc3csyh	948	2	.	.	.
cord-270892-ycc3csyh	949	1	Michael	Michael	NNP
cord-270892-ycc3csyh	949	2	acceptor	acceptor	NN
cord-270892-ycc3csyh	949	3	structure	structure	NN
cord-270892-ycc3csyh	949	4	-	-	HYPH
cord-270892-ycc3csyh	949	5	activity	activity	NN
cord-270892-ycc3csyh	949	6	studies	study	NNS
cord-270892-ycc3csyh	949	7	Structure	structure	NN
cord-270892-ycc3csyh	949	8	-	-	HYPH
cord-270892-ycc3csyh	949	9	based	base	VBN
cord-270892-ycc3csyh	949	10	design	design	NN
cord-270892-ycc3csyh	949	11	,	,	,
cord-270892-ycc3csyh	949	12	synthesis	synthesis	NN
cord-270892-ycc3csyh	949	13	,	,	,
cord-270892-ycc3csyh	949	14	and	and	CC
cord-270892-ycc3csyh	949	15	biological	biological	JJ
cord-270892-ycc3csyh	949	16	evaluation	evaluation	NN
cord-270892-ycc3csyh	949	17	of	of	IN
cord-270892-ycc3csyh	949	18	irreversible	irreversible	JJ
cord-270892-ycc3csyh	949	19	human	human	JJ
cord-270892-ycc3csyh	949	20	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	949	21	3C	3C	NNP
cord-270892-ycc3csyh	949	22	protease	protease	NN
cord-270892-ycc3csyh	949	23	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	949	24	.	.	.
cord-270892-ycc3csyh	950	1	2	2	LS
cord-270892-ycc3csyh	950	2	.	.	.
cord-270892-ycc3csyh	951	1	Peptide	peptide	NN
cord-270892-ycc3csyh	951	2	structure	structure	NN
cord-270892-ycc3csyh	951	3	-	-	HYPH
cord-270892-ycc3csyh	951	4	activity	activity	NN
cord-270892-ycc3csyh	951	5	studies	study	NNS
cord-270892-ycc3csyh	951	6	Structure	structure	NN
cord-270892-ycc3csyh	951	7	-	-	HYPH
cord-270892-ycc3csyh	951	8	based	base	VBN
cord-270892-ycc3csyh	951	9	design	design	NN
cord-270892-ycc3csyh	951	10	,	,	,
cord-270892-ycc3csyh	951	11	synthesis	synthesis	NN
cord-270892-ycc3csyh	951	12	,	,	,
cord-270892-ycc3csyh	951	13	and	and	CC
cord-270892-ycc3csyh	951	14	biological	biological	JJ
cord-270892-ycc3csyh	951	15	evaluation	evaluation	NN
cord-270892-ycc3csyh	951	16	of	of	IN
cord-270892-ycc3csyh	951	17	irreversible	irreversible	JJ
cord-270892-ycc3csyh	951	18	human	human	JJ
cord-270892-ycc3csyh	951	19	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	951	20	3C	3C	NNP
cord-270892-ycc3csyh	951	21	protease	protease	NN
cord-270892-ycc3csyh	951	22	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	951	23	.	.	.
cord-270892-ycc3csyh	952	1	6	6	LS
cord-270892-ycc3csyh	952	2	.	.	.
cord-270892-ycc3csyh	953	1	Structure	structure	NN
cord-270892-ycc3csyh	953	2	-	-	HYPH
cord-270892-ycc3csyh	953	3	activity	activity	NN
cord-270892-ycc3csyh	953	4	studies	study	NNS
cord-270892-ycc3csyh	953	5	of	of	IN
cord-270892-ycc3csyh	953	6	orally	orally	RB
cord-270892-ycc3csyh	953	7	bioavailable	bioavailable	JJ
cord-270892-ycc3csyh	953	8	,	,	,
cord-270892-ycc3csyh	953	9	2-pyridone	2-pyridone	CD
cord-270892-ycc3csyh	953	10	-	-	HYPH
cord-270892-ycc3csyh	953	11	containing	contain	VBG
cord-270892-ycc3csyh	953	12	peptidomimetics	peptidomimetic	NNS
cord-270892-ycc3csyh	953	13	Structure	Structure	NNP
cord-270892-ycc3csyh	953	14	-	-	HYPH
cord-270892-ycc3csyh	953	15	based	base	VBN
cord-270892-ycc3csyh	953	16	design	design	NN
cord-270892-ycc3csyh	953	17	,	,	,
cord-270892-ycc3csyh	953	18	synthesis	synthesis	NN
cord-270892-ycc3csyh	953	19	,	,	,
cord-270892-ycc3csyh	953	20	and	and	CC
cord-270892-ycc3csyh	953	21	biological	biological	JJ
cord-270892-ycc3csyh	953	22	evaluation	evaluation	NN
cord-270892-ycc3csyh	953	23	of	of	IN
cord-270892-ycc3csyh	953	24	irreversible	irreversible	JJ
cord-270892-ycc3csyh	953	25	human	human	JJ
cord-270892-ycc3csyh	953	26	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	953	27	3C	3C	NNP
cord-270892-ycc3csyh	953	28	protease	protease	NN
cord-270892-ycc3csyh	953	29	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	953	30	.	.	.
cord-270892-ycc3csyh	954	1	3	3	LS
cord-270892-ycc3csyh	954	2	.	.	.
cord-270892-ycc3csyh	955	1	Structure	structure	NN
cord-270892-ycc3csyh	955	2	-	-	HYPH
cord-270892-ycc3csyh	955	3	activity	activity	NN
cord-270892-ycc3csyh	955	4	studies	study	NNS
cord-270892-ycc3csyh	955	5	of	of	IN
cord-270892-ycc3csyh	955	6	ketomethylene	ketomethylene	NNP
cord-270892-ycc3csyh	955	7	-	-	HYPH
cord-270892-ycc3csyh	955	8	containing	contain	VBG
cord-270892-ycc3csyh	955	9	peptidomimetics	peptidomimetic	NNS
cord-270892-ycc3csyh	955	10	Structurebased	Structurebased	NNP
cord-270892-ycc3csyh	955	11	design	design	NN
cord-270892-ycc3csyh	955	12	,	,	,
cord-270892-ycc3csyh	955	13	synthesis	synthesis	NN
cord-270892-ycc3csyh	955	14	,	,	,
cord-270892-ycc3csyh	955	15	and	and	CC
cord-270892-ycc3csyh	955	16	biological	biological	JJ
cord-270892-ycc3csyh	955	17	evaluation	evaluation	NN
cord-270892-ycc3csyh	955	18	of	of	IN
cord-270892-ycc3csyh	955	19	irreversible	irreversible	JJ
cord-270892-ycc3csyh	955	20	human	human	JJ
cord-270892-ycc3csyh	955	21	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	955	22	3C	3C	NNP
cord-270892-ycc3csyh	955	23	protease	protease	NNP
cord-270892-ycc3csyh	955	24	inhibitors	inhibitors	NNP
cord-270892-ycc3csyh	955	25	Structure	Structure	NNP
cord-270892-ycc3csyh	955	26	-	-	HYPH
cord-270892-ycc3csyh	955	27	based	base	VBN
cord-270892-ycc3csyh	955	28	design	design	NN
cord-270892-ycc3csyh	955	29	,	,	,
cord-270892-ycc3csyh	955	30	synthesis	synthesis	NN
cord-270892-ycc3csyh	955	31	,	,	,
cord-270892-ycc3csyh	955	32	and	and	CC
cord-270892-ycc3csyh	955	33	biological	biological	JJ
cord-270892-ycc3csyh	955	34	evaluation	evaluation	NN
cord-270892-ycc3csyh	955	35	of	of	IN
cord-270892-ycc3csyh	955	36	irreversible	irreversible	JJ
cord-270892-ycc3csyh	955	37	human	human	JJ
cord-270892-ycc3csyh	955	38	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	955	39	3C	3C	NNP
cord-270892-ycc3csyh	955	40	protease	protease	NN
cord-270892-ycc3csyh	955	41	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	955	42	.	.	.
cord-270892-ycc3csyh	956	1	8	8	CD
cord-270892-ycc3csyh	956	2	.	.	.
cord-270892-ycc3csyh	957	1	Pharmacological	pharmacological	JJ
cord-270892-ycc3csyh	957	2	optimization	optimization	NN
cord-270892-ycc3csyh	957	3	of	of	IN
cord-270892-ycc3csyh	957	4	orally	orally	RB
cord-270892-ycc3csyh	957	5	bioavailable	bioavailable	JJ
cord-270892-ycc3csyh	957	6	2-pyridone	2-pyridone	CD
cord-270892-ycc3csyh	957	7	-	-	HYPH
cord-270892-ycc3csyh	957	8	containing	contain	VBG
cord-270892-ycc3csyh	957	9	peptidomimetics	peptidomimetic	NNS
cord-270892-ycc3csyh	957	10	Structure	Structure	NNP
cord-270892-ycc3csyh	957	11	-	-	HYPH
cord-270892-ycc3csyh	957	12	based	base	VBN
cord-270892-ycc3csyh	957	13	design	design	NN
cord-270892-ycc3csyh	957	14	,	,	,
cord-270892-ycc3csyh	957	15	synthesis	synthesis	NN
cord-270892-ycc3csyh	957	16	,	,	,
cord-270892-ycc3csyh	957	17	and	and	CC
cord-270892-ycc3csyh	957	18	biological	biological	JJ
cord-270892-ycc3csyh	957	19	evaluation	evaluation	NN
cord-270892-ycc3csyh	957	20	of	of	IN
cord-270892-ycc3csyh	957	21	irreversible	irreversible	JJ
cord-270892-ycc3csyh	957	22	human	human	JJ
cord-270892-ycc3csyh	957	23	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	957	24	3C	3C	NNP
cord-270892-ycc3csyh	957	25	protease	protease	NN
cord-270892-ycc3csyh	957	26	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	957	27	.	.	.
cord-270892-ycc3csyh	958	1	4	4	LS
cord-270892-ycc3csyh	958	2	.	.	.
cord-270892-ycc3csyh	959	1	Incorporation	Incorporation	NNP
cord-270892-ycc3csyh	959	2	of	of	IN
cord-270892-ycc3csyh	959	3	P1	P1	NNP
cord-270892-ycc3csyh	959	4	lactam	lactam	NNS
cord-270892-ycc3csyh	959	5	moieties	moiety	NNS
cord-270892-ycc3csyh	959	6	as	as	IN
cord-270892-ycc3csyh	959	7	L	l	NN
cord-270892-ycc3csyh	959	8	-	-	HYPH
cord-270892-ycc3csyh	959	9	glutamine	glutamine	NN
cord-270892-ycc3csyh	959	10	replacements	replacement	NNS
cord-270892-ycc3csyh	960	1	In	in	IN
cord-270892-ycc3csyh	960	2	vitro	vitro	FW
cord-270892-ycc3csyh	960	3	antiviral	antiviral	JJ
cord-270892-ycc3csyh	960	4	activity	activity	NN
cord-270892-ycc3csyh	960	5	of	of	IN
cord-270892-ycc3csyh	960	6	AG7088	ag7088	NN
cord-270892-ycc3csyh	960	7	,	,	,
cord-270892-ycc3csyh	960	8	a	a	DT
cord-270892-ycc3csyh	960	9	potent	potent	JJ
cord-270892-ycc3csyh	960	10	inhibitor	inhibitor	NN
cord-270892-ycc3csyh	960	11	of	of	IN
cord-270892-ycc3csyh	960	12	human	human	JJ
cord-270892-ycc3csyh	960	13	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	960	14	3C	3C	NNP
cord-270892-ycc3csyh	960	15	protease	protease	NNP
cord-270892-ycc3csyh	960	16	Inhibition	Inhibition	NNP
cord-270892-ycc3csyh	960	17	of	of	IN
cord-270892-ycc3csyh	960	18	human	human	JJ
cord-270892-ycc3csyh	960	19	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	960	20	-	-	HYPH
cord-270892-ycc3csyh	960	21	induced	induce	VBN
cord-270892-ycc3csyh	960	22	cytokine	cytokine	NN
cord-270892-ycc3csyh	960	23	production	production	NN
cord-270892-ycc3csyh	960	24	by	by	IN
cord-270892-ycc3csyh	960	25	AG7088	AG7088	NNP
cord-270892-ycc3csyh	960	26	,	,	,
cord-270892-ycc3csyh	960	27	a	a	DT
cord-270892-ycc3csyh	960	28	human	human	JJ
cord-270892-ycc3csyh	960	29	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	960	30	3C	3C	NNP
cord-270892-ycc3csyh	960	31	protease	protease	NN
cord-270892-ycc3csyh	960	32	inhibitor	inhibitor	NN
cord-270892-ycc3csyh	960	33	Pharmacokinetics	Pharmacokinetics	NNP
cord-270892-ycc3csyh	960	34	and	and	CC
cord-270892-ycc3csyh	960	35	safety	safety	NN
cord-270892-ycc3csyh	960	36	of	of	IN
cord-270892-ycc3csyh	960	37	an	an	DT
cord-270892-ycc3csyh	960	38	antirhinoviral	antirhinoviral	JJ
cord-270892-ycc3csyh	960	39	agent	agent	NN
cord-270892-ycc3csyh	960	40	,	,	,
cord-270892-ycc3csyh	960	41	ruprintrivir	ruprintrivir	NNP
cord-270892-ycc3csyh	960	42	,	,	,
cord-270892-ycc3csyh	960	43	in	in	IN
cord-270892-ycc3csyh	960	44	healthy	healthy	JJ
cord-270892-ycc3csyh	960	45	volunteers	volunteer	NNS
cord-270892-ycc3csyh	960	46	Phase	Phase	NNP
cord-270892-ycc3csyh	960	47	II	II	NNP
cord-270892-ycc3csyh	960	48	,	,	,
cord-270892-ycc3csyh	960	49	randomized	randomized	JJ
cord-270892-ycc3csyh	960	50	,	,	,
cord-270892-ycc3csyh	960	51	double	double	JJ
cord-270892-ycc3csyh	960	52	-	-	HYPH
cord-270892-ycc3csyh	960	53	blind	blind	JJ
cord-270892-ycc3csyh	960	54	,	,	,
cord-270892-ycc3csyh	960	55	placebo	placebo	NN
cord-270892-ycc3csyh	960	56	-	-	HYPH
cord-270892-ycc3csyh	960	57	controlled	control	VBN
cord-270892-ycc3csyh	960	58	studies	study	NNS
cord-270892-ycc3csyh	960	59	of	of	IN
cord-270892-ycc3csyh	960	60	ruprintrivir	ruprintrivir	NNP
cord-270892-ycc3csyh	960	61	nasal	nasal	NN
cord-270892-ycc3csyh	960	62	spray	spray	NN
cord-270892-ycc3csyh	960	63	2-percent	2-percent	CD
cord-270892-ycc3csyh	960	64	suspension	suspension	NN
cord-270892-ycc3csyh	960	65	for	for	IN
cord-270892-ycc3csyh	960	66	prevention	prevention	NN
cord-270892-ycc3csyh	960	67	and	and	CC
cord-270892-ycc3csyh	960	68	treatment	treatment	NN
cord-270892-ycc3csyh	960	69	of	of	IN
cord-270892-ycc3csyh	960	70	experimentally	experimentally	RB
cord-270892-ycc3csyh	960	71	induced	induce	VBN
cord-270892-ycc3csyh	960	72	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	960	73	colds	cold	NNS
cord-270892-ycc3csyh	960	74	in	in	IN
cord-270892-ycc3csyh	960	75	healthy	healthy	JJ
cord-270892-ycc3csyh	960	76	volunteers	volunteer	NNS
cord-270892-ycc3csyh	961	1	In	in	IN
cord-270892-ycc3csyh	961	2	vitro	vitro	FW
cord-270892-ycc3csyh	961	3	antiviral	antiviral	JJ
cord-270892-ycc3csyh	961	4	activity	activity	NN
cord-270892-ycc3csyh	961	5	and	and	CC
cord-270892-ycc3csyh	961	6	single	single	JJ
cord-270892-ycc3csyh	961	7	-	-	HYPH
cord-270892-ycc3csyh	961	8	dose	dose	NN
cord-270892-ycc3csyh	961	9	pharmacokinetics	pharmacokinetic	NNS
cord-270892-ycc3csyh	961	10	in	in	IN
cord-270892-ycc3csyh	961	11	humans	human	NNS
cord-270892-ycc3csyh	961	12	of	of	IN
cord-270892-ycc3csyh	961	13	a	a	DT
cord-270892-ycc3csyh	961	14	novel	novel	NN
cord-270892-ycc3csyh	961	15	,	,	,
cord-270892-ycc3csyh	961	16	orally	orally	RB
cord-270892-ycc3csyh	961	17	bioavailable	bioavailable	JJ
cord-270892-ycc3csyh	961	18	inhibitor	inhibitor	NN
cord-270892-ycc3csyh	961	19	of	of	IN
cord-270892-ycc3csyh	961	20	human	human	JJ
cord-270892-ycc3csyh	961	21	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	961	22	3C	3C	NNP
cord-270892-ycc3csyh	961	23	protease	protease	NNP
cord-270892-ycc3csyh	961	24	Gaining	gain	VBG
cord-270892-ycc3csyh	961	25	target	target	NN
cord-270892-ycc3csyh	961	26	access	access	NN
cord-270892-ycc3csyh	961	27	for	for	IN
cord-270892-ycc3csyh	961	28	deoxyribozymes	deoxyribozyme	NNS
cord-270892-ycc3csyh	962	1	A	a	DT
cord-270892-ycc3csyh	962	2	morpholino	morpholino	NNP
cord-270892-ycc3csyh	962	3	oligomer	oligomer	NNP
cord-270892-ycc3csyh	962	4	targeting	target	VBG
cord-270892-ycc3csyh	962	5	highly	highly	RB
cord-270892-ycc3csyh	962	6	conserved	conserve	VBN
cord-270892-ycc3csyh	962	7	internal	internal	JJ
cord-270892-ycc3csyh	962	8	ribosome	ribosome	NN
cord-270892-ycc3csyh	962	9	entry	entry	NN
cord-270892-ycc3csyh	962	10	site	site	NN
cord-270892-ycc3csyh	962	11	sequence	sequence	NN
cord-270892-ycc3csyh	962	12	is	be	VBZ
cord-270892-ycc3csyh	962	13	able	able	JJ
cord-270892-ycc3csyh	962	14	to	to	TO
cord-270892-ycc3csyh	962	15	inhibit	inhibit	VB
cord-270892-ycc3csyh	962	16	multiple	multiple	JJ
cord-270892-ycc3csyh	962	17	species	specie	NNS
cord-270892-ycc3csyh	962	18	of	of	IN
cord-270892-ycc3csyh	962	19	picornavirus	picornavirus	NN
cord-270892-ycc3csyh	962	20	Small	Small	NNP
cord-270892-ycc3csyh	962	21	interfering	interfere	VBG
cord-270892-ycc3csyh	962	22	RNA	RNA	NNP
cord-270892-ycc3csyh	962	23	molecules	molecule	NNS
cord-270892-ycc3csyh	962	24	as	as	IN
cord-270892-ycc3csyh	962	25	potential	potential	JJ
cord-270892-ycc3csyh	962	26	anti	anti	JJ
cord-270892-ycc3csyh	962	27	-	-	JJ
cord-270892-ycc3csyh	962	28	human	human	JJ
cord-270892-ycc3csyh	962	29	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	962	30	agents	agent	NNS
cord-270892-ycc3csyh	962	31	:	:	:
cord-270892-ycc3csyh	963	1	In	in	IN
cord-270892-ycc3csyh	963	2	vitro	vitro	FW
cord-270892-ycc3csyh	963	3	potency	potency	NN
cord-270892-ycc3csyh	963	4	,	,	,
cord-270892-ycc3csyh	963	5	specificity	specificity	NN
cord-270892-ycc3csyh	963	6	,	,	,
cord-270892-ycc3csyh	963	7	and	and	CC
cord-270892-ycc3csyh	963	8	mechanism	mechanism	NN
cord-270892-ycc3csyh	963	9	Mode	mode	NN
cord-270892-ycc3csyh	963	10	of	of	IN
cord-270892-ycc3csyh	963	11	action	action	NN
cord-270892-ycc3csyh	963	12	of	of	IN
cord-270892-ycc3csyh	963	13	2-furylmercury	2-furylmercury	CD
cord-270892-ycc3csyh	963	14	chloride	chloride	NN
cord-270892-ycc3csyh	963	15	,	,	,
cord-270892-ycc3csyh	963	16	an	an	DT
cord-270892-ycc3csyh	963	17	antirhinovirus	antirhinovirus	JJ
cord-270892-ycc3csyh	963	18	compound	compound	NN
cord-270892-ycc3csyh	963	19	Methoxyflavones	Methoxyflavones	NNPS
cord-270892-ycc3csyh	963	20	as	as	IN
cord-270892-ycc3csyh	963	21	potent	potent	JJ
cord-270892-ycc3csyh	963	22	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	963	23	of	of	IN
cord-270892-ycc3csyh	963	24	viral	viral	RB
cord-270892-ycc3csyh	963	25	-	-	HYPH
cord-270892-ycc3csyh	963	26	induced	induce	VBN
cord-270892-ycc3csyh	963	27	block	block	NN
cord-270892-ycc3csyh	963	28	of	of	IN
cord-270892-ycc3csyh	963	29	cell	cell	NN
cord-270892-ycc3csyh	963	30	synthesis	synthesis	NN
cord-270892-ycc3csyh	963	31	Antiviral	antiviral	JJ
cord-270892-ycc3csyh	963	32	effects	effect	NNS
cord-270892-ycc3csyh	963	33	of	of	IN
cord-270892-ycc3csyh	963	34	pyrrolidine	pyrrolidine	JJ
cord-270892-ycc3csyh	963	35	dithiocarbamate	dithiocarbamate	NNP
cord-270892-ycc3csyh	963	36	on	on	IN
cord-270892-ycc3csyh	963	37	human	human	JJ
cord-270892-ycc3csyh	963	38	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	963	39	Broad	Broad	NNP
cord-270892-ycc3csyh	963	40	-	-	HYPH
cord-270892-ycc3csyh	963	41	spectrum	spectrum	NN
cord-270892-ycc3csyh	963	42	antiviral	antiviral	JJ
cord-270892-ycc3csyh	963	43	and	and	CC
cord-270892-ycc3csyh	963	44	cytocidal	cytocidal	JJ
cord-270892-ycc3csyh	963	45	activity	activity	NN
cord-270892-ycc3csyh	963	46	of	of	IN
cord-270892-ycc3csyh	963	47	cyclopentenylcytosine	cyclopentenylcytosine	NNP
cord-270892-ycc3csyh	963	48	,	,	,
cord-270892-ycc3csyh	963	49	a	a	DT
cord-270892-ycc3csyh	963	50	carbocyclic	carbocyclic	JJ
cord-270892-ycc3csyh	963	51	nucleoside	nucleoside	NN
cord-270892-ycc3csyh	963	52	targeted	target	VBN
cord-270892-ycc3csyh	963	53	at	at	IN
cord-270892-ycc3csyh	963	54	CTP	CTP	NNP
cord-270892-ycc3csyh	963	55	synthetase	synthetase	NNP
cord-270892-ycc3csyh	964	1	In	in	IN
cord-270892-ycc3csyh	964	2	vitro	vitro	FW
cord-270892-ycc3csyh	964	3	antiviral	antiviral	JJ
cord-270892-ycc3csyh	964	4	activity	activity	NN
cord-270892-ycc3csyh	964	5	of	of	IN
cord-270892-ycc3csyh	964	6	ribavirin	ribavirin	NN
cord-270892-ycc3csyh	964	7	against	against	IN
cord-270892-ycc3csyh	964	8	picornaviruses	picornavirus	NNS
cord-270892-ycc3csyh	965	1	Another	another	DT
cord-270892-ycc3csyh	965	2	ten	ten	CD
cord-270892-ycc3csyh	965	3	stories	story	NNS
cord-270892-ycc3csyh	965	4	in	in	IN
cord-270892-ycc3csyh	965	5	antiviral	antiviral	JJ
cord-270892-ycc3csyh	965	6	drug	drug	NN
cord-270892-ycc3csyh	965	7	discovery	discovery	NN
cord-270892-ycc3csyh	965	8	(	(	-LRB-
cord-270892-ycc3csyh	965	9	part	part	NN
cord-270892-ycc3csyh	965	10	C	C	NNP
cord-270892-ycc3csyh	965	11	)	)	-RRB-
cord-270892-ycc3csyh	965	12	:	:	:
cord-270892-ycc3csyh	965	13	'	'	''
cord-270892-ycc3csyh	965	14	'	'	``
cord-270892-ycc3csyh	965	15	Old	Old	NNP
cord-270892-ycc3csyh	965	16	'	'	''
cord-270892-ycc3csyh	965	17	'	'	''
cord-270892-ycc3csyh	965	18	and	and	CC
cord-270892-ycc3csyh	965	19	'	'	``
cord-270892-ycc3csyh	965	20	'	'	``
cord-270892-ycc3csyh	965	21	new	new	JJ
cord-270892-ycc3csyh	965	22	'	'	''
cord-270892-ycc3csyh	965	23	'	'	''
cord-270892-ycc3csyh	965	24	antivirals	antiviral	NNS
cord-270892-ycc3csyh	965	25	,	,	,
cord-270892-ycc3csyh	965	26	strategies	strategy	NNS
cord-270892-ycc3csyh	965	27	,	,	,
cord-270892-ycc3csyh	965	28	and	and	CC
cord-270892-ycc3csyh	965	29	perspectives	perspective	NNS
cord-270892-ycc3csyh	966	1	The	the	DT
cord-270892-ycc3csyh	966	2	broadspectrum	broadspectrum	NNP
cord-270892-ycc3csyh	966	3	antiviral	antiviral	JJ
cord-270892-ycc3csyh	966	4	ribonucleoside	ribonucleoside	NN
cord-270892-ycc3csyh	966	5	ribavirin	ribavirin	RB
cord-270892-ycc3csyh	966	6	is	be	VBZ
cord-270892-ycc3csyh	966	7	an	an	DT
cord-270892-ycc3csyh	966	8	RNA	RNA	NNP
cord-270892-ycc3csyh	966	9	virus	virus	NN
cord-270892-ycc3csyh	966	10	mutagen	mutagen	NN
cord-270892-ycc3csyh	966	11	Ribavirin	ribavirin	RB
cord-270892-ycc3csyh	966	12	:	:	:
cord-270892-ycc3csyh	967	1	Recent	recent	JJ
cord-270892-ycc3csyh	967	2	insights	insight	NNS
cord-270892-ycc3csyh	967	3	into	into	IN
cord-270892-ycc3csyh	967	4	antiviral	antiviral	JJ
cord-270892-ycc3csyh	967	5	mechanisms	mechanism	NNS
cord-270892-ycc3csyh	967	6	of	of	IN
cord-270892-ycc3csyh	967	7	action	action	NN
cord-270892-ycc3csyh	967	8	Inhibition	inhibition	NN
cord-270892-ycc3csyh	967	9	of	of	IN
cord-270892-ycc3csyh	967	10	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	967	11	replication	replication	NN
cord-270892-ycc3csyh	967	12	in	in	IN
cord-270892-ycc3csyh	967	13	in	in	IN
cord-270892-ycc3csyh	967	14	organ	organ	NN
cord-270892-ycc3csyh	967	15	culture	culture	NN
cord-270892-ycc3csyh	967	16	by	by	IN
cord-270892-ycc3csyh	967	17	a	a	DT
cord-270892-ycc3csyh	967	18	potential	potential	JJ
cord-270892-ycc3csyh	967	19	antiviral	antiviral	JJ
cord-270892-ycc3csyh	967	20	drug	drug	NN
cord-270892-ycc3csyh	967	21	Synthesis	Synthesis	NNP
cord-270892-ycc3csyh	967	22	of	of	IN
cord-270892-ycc3csyh	967	23	syn	syn	NN
cord-270892-ycc3csyh	967	24	and	and	CC
cord-270892-ycc3csyh	967	25	anti	anti	JJ
cord-270892-ycc3csyh	967	26	isomers	isomer	NNS
cord-270892-ycc3csyh	967	27	of	of	IN
cord-270892-ycc3csyh	968	1	6-[[(hydroxyimino)phenyl]methyl]-1-[(1-methylethyl)sulfonyl]-1H	6-[[(hydroxyimino)phenyl]methyl]-1-[(1-methylethyl)sulfonyl]-1h	LS
cord-270892-ycc3csyh	968	2	-	-	HYPH
cord-270892-ycc3csyh	968	3	benzimidaz	benzimidaz	NNP
cord-270892-ycc3csyh	968	4	ol-2-amine	ol-2-amine	NN
cord-270892-ycc3csyh	968	5	.	.	.
cord-270892-ycc3csyh	969	1	Inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	969	2	of	of	IN
cord-270892-ycc3csyh	969	3	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	969	4	multiplication	multiplication	NN
cord-270892-ycc3csyh	969	5	Comparative	Comparative	NNP
cord-270892-ycc3csyh	969	6	studies	study	NNS
cord-270892-ycc3csyh	969	7	on	on	IN
cord-270892-ycc3csyh	969	8	the	the	DT
cord-270892-ycc3csyh	969	9	modes	mode	NNS
cord-270892-ycc3csyh	969	10	of	of	IN
cord-270892-ycc3csyh	969	11	action	action	NN
cord-270892-ycc3csyh	969	12	of	of	IN
cord-270892-ycc3csyh	969	13	the	the	DT
cord-270892-ycc3csyh	969	14	antirhinovirus	antirhinovirus	JJ
cord-270892-ycc3csyh	969	15	agents	agent	NNS
cord-270892-ycc3csyh	969	16	Ro	Ro	NNP
cord-270892-ycc3csyh	969	17	09	09	CD
cord-270892-ycc3csyh	969	18	-	-	HYPH
cord-270892-ycc3csyh	969	19	0410	0410	CD
cord-270892-ycc3csyh	969	20	,	,	,
cord-270892-ycc3csyh	969	21	Ro	Ro	NNP
cord-270892-ycc3csyh	969	22	09	09	CD
cord-270892-ycc3csyh	969	23	-	-	HYPH
cord-270892-ycc3csyh	969	24	0179	0179	CD
cord-270892-ycc3csyh	969	25	,	,	,
cord-270892-ycc3csyh	969	26	RMI-15,731	RMI-15,731	NNS
cord-270892-ycc3csyh	969	27	,	,	,
cord-270892-ycc3csyh	969	28	4	4	CD
cord-270892-ycc3csyh	969	29	0	0	CD
cord-270892-ycc3csyh	969	30	,	,	,
cord-270892-ycc3csyh	969	31	6-dichloroflavan	6-dichloroflavan	CD
cord-270892-ycc3csyh	969	32	,	,	,
cord-270892-ycc3csyh	969	33	and	and	CC
cord-270892-ycc3csyh	969	34	enviroxime	enviroxime	NN
cord-270892-ycc3csyh	969	35	The	the	DT
cord-270892-ycc3csyh	969	36	antiviral	antiviral	JJ
cord-270892-ycc3csyh	969	37	compound	compound	NN
cord-270892-ycc3csyh	969	38	enviroxime	enviroxime	NN
cord-270892-ycc3csyh	969	39	targets	target	VBZ
cord-270892-ycc3csyh	969	40	the	the	DT
cord-270892-ycc3csyh	969	41	3A	3A	NNP
cord-270892-ycc3csyh	969	42	coding	code	VBG
cord-270892-ycc3csyh	969	43	region	region	NN
cord-270892-ycc3csyh	969	44	of	of	IN
cord-270892-ycc3csyh	969	45	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	969	46	and	and	CC
cord-270892-ycc3csyh	969	47	poliovirus	poliovirus	NN
cord-270892-ycc3csyh	970	1	Sequence	sequence	NN
cord-270892-ycc3csyh	970	2	determinants	determinant	NNS
cord-270892-ycc3csyh	970	3	of	of	IN
cord-270892-ycc3csyh	970	4	3A	3a	CD
cord-270892-ycc3csyh	970	5	-	-	HYPH
cord-270892-ycc3csyh	970	6	mediated	mediate	VBN
cord-270892-ycc3csyh	970	7	resistance	resistance	NN
cord-270892-ycc3csyh	970	8	to	to	IN
cord-270892-ycc3csyh	970	9	enviroxime	enviroxime	NN
cord-270892-ycc3csyh	970	10	in	in	IN
cord-270892-ycc3csyh	970	11	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	970	12	and	and	CC
cord-270892-ycc3csyh	970	13	enteroviruses	enteroviruses	NNP
cord-270892-ycc3csyh	970	14	Evidence	evidence	NN
cord-270892-ycc3csyh	970	15	that	that	IN
cord-270892-ycc3csyh	970	16	enviroxime	enviroxime	NN
cord-270892-ycc3csyh	970	17	targets	target	VBZ
cord-270892-ycc3csyh	970	18	multiple	multiple	JJ
cord-270892-ycc3csyh	970	19	components	component	NNS
cord-270892-ycc3csyh	970	20	of	of	IN
cord-270892-ycc3csyh	970	21	the	the	DT
cord-270892-ycc3csyh	970	22	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	970	23	14	14	CD
cord-270892-ycc3csyh	970	24	replication	replication	NN
cord-270892-ycc3csyh	970	25	complex	complex	NN
cord-270892-ycc3csyh	970	26	Controlled	control	VBN
cord-270892-ycc3csyh	970	27	trial	trial	NN
cord-270892-ycc3csyh	970	28	of	of	IN
cord-270892-ycc3csyh	970	29	enviroxime	enviroxime	NN
cord-270892-ycc3csyh	970	30	against	against	IN
cord-270892-ycc3csyh	970	31	natural	natural	JJ
cord-270892-ycc3csyh	970	32	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	970	33	infections	infection	NNS
cord-270892-ycc3csyh	970	34	in	in	IN
cord-270892-ycc3csyh	970	35	a	a	DT
cord-270892-ycc3csyh	970	36	community	community	NN
cord-270892-ycc3csyh	971	1	The	the	DT
cord-270892-ycc3csyh	971	2	activity	activity	NN
cord-270892-ycc3csyh	971	3	of	of	IN
cord-270892-ycc3csyh	971	4	enviroxime	enviroxime	NN
cord-270892-ycc3csyh	971	5	against	against	IN
cord-270892-ycc3csyh	971	6	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	971	7	infection	infection	NN
cord-270892-ycc3csyh	971	8	in	in	IN
cord-270892-ycc3csyh	971	9	man	man	NN
cord-270892-ycc3csyh	971	10	Activity	activity	NN
cord-270892-ycc3csyh	971	11	against	against	IN
cord-270892-ycc3csyh	971	12	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	971	13	,	,	,
cord-270892-ycc3csyh	971	14	toxicity	toxicity	NN
cord-270892-ycc3csyh	971	15	,	,	,
cord-270892-ycc3csyh	971	16	and	and	CC
cord-270892-ycc3csyh	971	17	delivery	delivery	NN
cord-270892-ycc3csyh	971	18	in	in	IN
cord-270892-ycc3csyh	971	19	aerosol	aerosol	NN
cord-270892-ycc3csyh	971	20	of	of	IN
cord-270892-ycc3csyh	971	21	enviroxime	enviroxime	NN
cord-270892-ycc3csyh	971	22	in	in	IN
cord-270892-ycc3csyh	971	23	liposomes	liposome	NNS
cord-270892-ycc3csyh	972	1	2-Amino-3-substituted-6-[(E)-1-phenyl-2-(N	2-amino-3-substituted-6-[(e)-1-phenyl-2-(n	CD
cord-270892-ycc3csyh	972	2	-	-	SYM
cord-270892-ycc3csyh	972	3	methylcarbamoyl)vinyl]imid	methylcarbamoyl)vinyl]imid	NNP
cord-270892-ycc3csyh	972	4	azo[1,2-a]pyridines	azo[1,2-a]pyridine	NNS
cord-270892-ycc3csyh	972	5	as	as	IN
cord-270892-ycc3csyh	972	6	a	a	DT
cord-270892-ycc3csyh	972	7	novel	novel	JJ
cord-270892-ycc3csyh	972	8	class	class	NN
cord-270892-ycc3csyh	972	9	of	of	IN
cord-270892-ycc3csyh	972	10	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	972	11	of	of	IN
cord-270892-ycc3csyh	972	12	human	human	JJ
cord-270892-ycc3csyh	972	13	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	972	14	:	:	:
cord-270892-ycc3csyh	972	15	Stereospecific	Stereospecific	NNP
cord-270892-ycc3csyh	972	16	synthesis	synthesis	NN
cord-270892-ycc3csyh	972	17	and	and	CC
cord-270892-ycc3csyh	972	18	antiviral	antiviral	JJ
cord-270892-ycc3csyh	972	19	activity	activity	NN
cord-270892-ycc3csyh	972	20	Short	short	JJ
cord-270892-ycc3csyh	972	21	synthesis	synthesis	NN
cord-270892-ycc3csyh	972	22	and	and	CC
cord-270892-ycc3csyh	972	23	anti	anti	JJ
cord-270892-ycc3csyh	972	24	-	-	JJ
cord-270892-ycc3csyh	972	25	rhinoviral	rhinoviral	JJ
cord-270892-ycc3csyh	972	26	activity	activity	NN
cord-270892-ycc3csyh	972	27	of	of	IN
cord-270892-ycc3csyh	972	28	imidazo[1,2-a]pyridines	imidazo[1,2-a]pyridine	NNS
cord-270892-ycc3csyh	972	29	:	:	:
cord-270892-ycc3csyh	973	1	The	the	DT
cord-270892-ycc3csyh	973	2	effect	effect	NN
cord-270892-ycc3csyh	973	3	of	of	IN
cord-270892-ycc3csyh	973	4	acyl	acyl	NN
cord-270892-ycc3csyh	973	5	groups	group	NNS
cord-270892-ycc3csyh	973	6	at	at	IN
cord-270892-ycc3csyh	973	7	3-position	3-position	CD
cord-270892-ycc3csyh	973	8	Synthesis	Synthesis	NNP
cord-270892-ycc3csyh	973	9	,	,	,
cord-270892-ycc3csyh	973	10	antiviral	antiviral	JJ
cord-270892-ycc3csyh	973	11	activity	activity	NN
cord-270892-ycc3csyh	973	12	,	,	,
cord-270892-ycc3csyh	973	13	and	and	CC
cord-270892-ycc3csyh	973	14	biological	biological	JJ
cord-270892-ycc3csyh	973	15	properties	property	NNS
cord-270892-ycc3csyh	973	16	of	of	IN
cord-270892-ycc3csyh	973	17	vinylacetylene	vinylacetylene	NN
cord-270892-ycc3csyh	973	18	analogs	analog	NNS
cord-270892-ycc3csyh	973	19	of	of	IN
cord-270892-ycc3csyh	973	20	enviroxime	enviroxime	NNP
cord-270892-ycc3csyh	973	21	Synthesis	Synthesis	NNP
cord-270892-ycc3csyh	973	22	and	and	CC
cord-270892-ycc3csyh	973	23	antiviral	antiviral	JJ
cord-270892-ycc3csyh	973	24	activity	activity	NN
cord-270892-ycc3csyh	973	25	of	of	IN
cord-270892-ycc3csyh	973	26	C2	C2	NNP
cord-270892-ycc3csyh	973	27	analogs	analog	NNS
cord-270892-ycc3csyh	973	28	of	of	IN
cord-270892-ycc3csyh	973	29	enviroxime	enviroxime	NN
cord-270892-ycc3csyh	973	30	:	:	:
cord-270892-ycc3csyh	973	31	An	an	DT
cord-270892-ycc3csyh	973	32	exploration	exploration	NN
cord-270892-ycc3csyh	973	33	of	of	IN
cord-270892-ycc3csyh	973	34	the	the	DT
cord-270892-ycc3csyh	973	35	role	role	NN
cord-270892-ycc3csyh	973	36	of	of	IN
cord-270892-ycc3csyh	973	37	critical	critical	JJ
cord-270892-ycc3csyh	973	38	functionality	functionality	NN
cord-270892-ycc3csyh	973	39	Sensitivity	sensitivity	NN
cord-270892-ycc3csyh	973	40	of	of	IN
cord-270892-ycc3csyh	973	41	rhinoviruses	rhinovirus	NNS
cord-270892-ycc3csyh	973	42	to	to	IN
cord-270892-ycc3csyh	973	43	human	human	JJ
cord-270892-ycc3csyh	973	44	leukocyte	leukocyte	NN
cord-270892-ycc3csyh	973	45	and	and	CC
cord-270892-ycc3csyh	973	46	fibroblast	fibroblast	NN
cord-270892-ycc3csyh	973	47	interferons	interferon	NNS
cord-270892-ycc3csyh	973	48	Cell	cell	NN
cord-270892-ycc3csyh	973	49	and	and	CC
cord-270892-ycc3csyh	973	50	virus	virus	NN
cord-270892-ycc3csyh	973	51	sensitivity	sensitivity	NN
cord-270892-ycc3csyh	973	52	studies	study	NNS
cord-270892-ycc3csyh	973	53	with	with	IN
cord-270892-ycc3csyh	973	54	recombinant	recombinant	JJ
cord-270892-ycc3csyh	973	55	human	human	JJ
cord-270892-ycc3csyh	973	56	alpha	alpha	NN
cord-270892-ycc3csyh	973	57	interferons	interferon	NNS
cord-270892-ycc3csyh	974	1	Comparative	comparative	JJ
cord-270892-ycc3csyh	974	2	susceptibility	susceptibility	NN
cord-270892-ycc3csyh	974	3	of	of	IN
cord-270892-ycc3csyh	974	4	respiratory	respiratory	JJ
cord-270892-ycc3csyh	974	5	viruses	virus	NNS
cord-270892-ycc3csyh	974	6	to	to	IN
cord-270892-ycc3csyh	974	7	recombinant	recombinant	JJ
cord-270892-ycc3csyh	974	8	interferons	interferon	NNS
cord-270892-ycc3csyh	974	9	-	-	HYPH
cord-270892-ycc3csyh	974	10	alpha	alpha	NN
cord-270892-ycc3csyh	974	11	2b	2b	NN
cord-270892-ycc3csyh	974	12	and	and	CC
cord-270892-ycc3csyh	975	1	-beta	-beta	:
cord-270892-ycc3csyh	975	2	Intranasal	Intranasal	NNP
cord-270892-ycc3csyh	976	1	interferon	interferon	NN
cord-270892-ycc3csyh	976	2	-	-	HYPH
cord-270892-ycc3csyh	976	3	alpha	alpha	NN
cord-270892-ycc3csyh	976	4	2	2	CD
cord-270892-ycc3csyh	976	5	for	for	IN
cord-270892-ycc3csyh	976	6	prevention	prevention	NN
cord-270892-ycc3csyh	976	7	of	of	IN
cord-270892-ycc3csyh	976	8	natural	natural	JJ
cord-270892-ycc3csyh	976	9	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	976	10	colds	cold	NNS
cord-270892-ycc3csyh	977	1	Intranasal	intranasal	NN
cord-270892-ycc3csyh	977	2	interferon	interferon	NN
cord-270892-ycc3csyh	977	3	alpha	alpha	NN
cord-270892-ycc3csyh	977	4	2	2	CD
cord-270892-ycc3csyh	977	5	for	for	IN
cord-270892-ycc3csyh	977	6	prevention	prevention	NN
cord-270892-ycc3csyh	977	7	of	of	IN
cord-270892-ycc3csyh	977	8	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	977	9	infection	infection	NN
cord-270892-ycc3csyh	977	10	and	and	CC
cord-270892-ycc3csyh	977	11	illness	illness	NN
cord-270892-ycc3csyh	977	12	Interferon	interferon	NN
cord-270892-ycc3csyh	977	13	-	-	HYPH
cord-270892-ycc3csyh	977	14	beta	beta	NN
cord-270892-ycc3csyh	977	15	ser	ser	NNP
cord-270892-ycc3csyh	977	16	as	as	IN
cord-270892-ycc3csyh	977	17	prophylaxis	prophylaxis	NN
cord-270892-ycc3csyh	977	18	against	against	IN
cord-270892-ycc3csyh	977	19	experimental	experimental	JJ
cord-270892-ycc3csyh	977	20	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	977	21	infection	infection	NN
cord-270892-ycc3csyh	977	22	in	in	IN
cord-270892-ycc3csyh	977	23	volunteers	volunteer	NNS
cord-270892-ycc3csyh	977	24	An	an	DT
cord-270892-ycc3csyh	977	25	effective	effective	JJ
cord-270892-ycc3csyh	977	26	dosage	dosage	NN
cord-270892-ycc3csyh	977	27	regimen	regimen	NN
cord-270892-ycc3csyh	977	28	for	for	IN
cord-270892-ycc3csyh	977	29	prophylaxis	prophylaxis	NN
cord-270892-ycc3csyh	977	30	against	against	IN
cord-270892-ycc3csyh	977	31	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	977	32	infection	infection	NN
cord-270892-ycc3csyh	977	33	by	by	IN
cord-270892-ycc3csyh	977	34	intranasal	intranasal	NNP
cord-270892-ycc3csyh	977	35	administration	administration	NN
cord-270892-ycc3csyh	977	36	of	of	IN
cord-270892-ycc3csyh	977	37	HuIFN	HuIFN	NNP
cord-270892-ycc3csyh	977	38	-	-	HYPH
cord-270892-ycc3csyh	977	39	alpha	alpha	NN
cord-270892-ycc3csyh	977	40	2	2	CD
cord-270892-ycc3csyh	977	41	Efficacy	efficacy	NN
cord-270892-ycc3csyh	977	42	and	and	CC
cord-270892-ycc3csyh	977	43	tolerance	tolerance	NN
cord-270892-ycc3csyh	977	44	of	of	IN
cord-270892-ycc3csyh	977	45	intranasally	intranasally	RB
cord-270892-ycc3csyh	977	46	applied	apply	VBN
cord-270892-ycc3csyh	977	47	recombinant	recombinant	JJ
cord-270892-ycc3csyh	977	48	leukocyte	leukocyte	NN
cord-270892-ycc3csyh	978	1	A	a	DT
cord-270892-ycc3csyh	978	2	interferon	interferon	NN
cord-270892-ycc3csyh	978	3	in	in	IN
cord-270892-ycc3csyh	978	4	normal	normal	JJ
cord-270892-ycc3csyh	978	5	volunteers	volunteer	NNS
cord-270892-ycc3csyh	978	6	Intranasally	intranasally	RB
cord-270892-ycc3csyh	978	7	applied	apply	VBD
cord-270892-ycc3csyh	978	8	recombinant	recombinant	JJ
cord-270892-ycc3csyh	978	9	leukocyte	leukocyte	NN
cord-270892-ycc3csyh	979	1	A	a	DT
cord-270892-ycc3csyh	979	2	interferon	interferon	NN
cord-270892-ycc3csyh	979	3	in	in	IN
cord-270892-ycc3csyh	979	4	normal	normal	JJ
cord-270892-ycc3csyh	979	5	volunteers	volunteer	NNS
cord-270892-ycc3csyh	979	6	.	.	.
cord-270892-ycc3csyh	980	1	II	II	NNP
cord-270892-ycc3csyh	980	2	.	.	.
cord-270892-ycc3csyh	981	1	Determination	determination	NN
cord-270892-ycc3csyh	981	2	of	of	IN
cord-270892-ycc3csyh	981	3	minimal	minimal	JJ
cord-270892-ycc3csyh	981	4	effective	effective	JJ
cord-270892-ycc3csyh	981	5	and	and	CC
cord-270892-ycc3csyh	981	6	tolerable	tolerable	JJ
cord-270892-ycc3csyh	981	7	dose	dose	NN
cord-270892-ycc3csyh	981	8	Recombinant	recombinant	JJ
cord-270892-ycc3csyh	981	9	human	human	JJ
cord-270892-ycc3csyh	981	10	interferon	interferon	NN
cord-270892-ycc3csyh	981	11	-	-	HYPH
cord-270892-ycc3csyh	981	12	gamma	gamma	NN
cord-270892-ycc3csyh	981	13	as	as	IN
cord-270892-ycc3csyh	981	14	prophylaxis	prophylaxis	NN
cord-270892-ycc3csyh	981	15	against	against	IN
cord-270892-ycc3csyh	981	16	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	981	17	colds	cold	NNS
cord-270892-ycc3csyh	981	18	in	in	IN
cord-270892-ycc3csyh	981	19	volunteers	volunteer	NNS
cord-270892-ycc3csyh	981	20	Ineffectiveness	Ineffectiveness	NNP
cord-270892-ycc3csyh	981	21	of	of	IN
cord-270892-ycc3csyh	981	22	postexposure	postexposure	NN
cord-270892-ycc3csyh	981	23	prophylaxis	prophylaxis	NN
cord-270892-ycc3csyh	981	24	of	of	IN
cord-270892-ycc3csyh	981	25	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	981	26	infection	infection	NN
cord-270892-ycc3csyh	981	27	with	with	IN
cord-270892-ycc3csyh	981	28	low	low	JJ
cord-270892-ycc3csyh	981	29	-	-	HYPH
cord-270892-ycc3csyh	981	30	dose	dose	NN
cord-270892-ycc3csyh	981	31	intranasal	intranasal	NN
cord-270892-ycc3csyh	981	32	alpha	alpha	NN
cord-270892-ycc3csyh	981	33	2b	2b	NNP
cord-270892-ycc3csyh	981	34	interferon	interferon	NNP
cord-270892-ycc3csyh	981	35	in	in	IN
cord-270892-ycc3csyh	981	36	families	family	NNS
cord-270892-ycc3csyh	982	1	A	a	DT
cord-270892-ycc3csyh	982	2	randomized	randomized	JJ
cord-270892-ycc3csyh	982	3	controlled	control	VBN
cord-270892-ycc3csyh	982	4	trial	trial	NN
cord-270892-ycc3csyh	982	5	of	of	IN
cord-270892-ycc3csyh	982	6	glucocorticoid	glucocorticoid	NN
cord-270892-ycc3csyh	982	7	prophylaxis	prophylaxis	NN
cord-270892-ycc3csyh	982	8	against	against	IN
cord-270892-ycc3csyh	982	9	experimental	experimental	JJ
cord-270892-ycc3csyh	982	10	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	982	11	infection	infection	NN
cord-270892-ycc3csyh	982	12	Synergism	synergism	NN
cord-270892-ycc3csyh	982	13	between	between	IN
cord-270892-ycc3csyh	982	14	anti	anti	JJ
cord-270892-ycc3csyh	982	15	-	-	JJ
cord-270892-ycc3csyh	982	16	rhinovirus	rhinovirus	JJ
cord-270892-ycc3csyh	982	17	antivirals	antiviral	NNS
cord-270892-ycc3csyh	982	18	:	:	:
cord-270892-ycc3csyh	982	19	Various	various	JJ
cord-270892-ycc3csyh	982	20	human	human	JJ
cord-270892-ycc3csyh	982	21	interferons	interferon	NNS
cord-270892-ycc3csyh	982	22	and	and	CC
cord-270892-ycc3csyh	982	23	a	a	DT
cord-270892-ycc3csyh	982	24	number	number	NN
cord-270892-ycc3csyh	982	25	of	of	IN
cord-270892-ycc3csyh	982	26	synthetic	synthetic	JJ
cord-270892-ycc3csyh	982	27	compounds	compound	NNS
cord-270892-ycc3csyh	982	28	Failure	failure	NN
cord-270892-ycc3csyh	982	29	to	to	TO
cord-270892-ycc3csyh	982	30	demonstrate	demonstrate	VB
cord-270892-ycc3csyh	982	31	synergy	synergy	NN
cord-270892-ycc3csyh	982	32	between	between	IN
cord-270892-ycc3csyh	982	33	interferon	interferon	NN
cord-270892-ycc3csyh	982	34	-	-	HYPH
cord-270892-ycc3csyh	982	35	alpha	alpha	NN
cord-270892-ycc3csyh	982	36	and	and	CC
cord-270892-ycc3csyh	982	37	a	a	DT
cord-270892-ycc3csyh	982	38	synthetic	synthetic	JJ
cord-270892-ycc3csyh	982	39	antiviral	antiviral	JJ
cord-270892-ycc3csyh	982	40	,	,	,
cord-270892-ycc3csyh	982	41	enviroxime	enviroxime	NN
cord-270892-ycc3csyh	982	42	,	,	,
cord-270892-ycc3csyh	982	43	in	in	IN
cord-270892-ycc3csyh	982	44	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	982	45	infections	infection	NNS
cord-270892-ycc3csyh	982	46	in	in	IN
cord-270892-ycc3csyh	982	47	volunteers	volunteer	NNS
cord-270892-ycc3csyh	982	48	Property	Property	NNP
cord-270892-ycc3csyh	982	49	distributions	distribution	NNS
cord-270892-ycc3csyh	982	50	:	:	:
cord-270892-ycc3csyh	982	51	Differences	difference	NNS
cord-270892-ycc3csyh	982	52	between	between	IN
cord-270892-ycc3csyh	982	53	drugs	drug	NNS
cord-270892-ycc3csyh	982	54	,	,	,
cord-270892-ycc3csyh	982	55	natural	natural	JJ
cord-270892-ycc3csyh	982	56	products	product	NNS
cord-270892-ycc3csyh	982	57	,	,	,
cord-270892-ycc3csyh	982	58	and	and	CC
cord-270892-ycc3csyh	982	59	molecules	molecule	NNS
cord-270892-ycc3csyh	982	60	from	from	IN
cord-270892-ycc3csyh	982	61	combinatorial	combinatorial	JJ
cord-270892-ycc3csyh	982	62	chemistry	chemistry	NN
cord-270892-ycc3csyh	983	1	A	a	DT
cord-270892-ycc3csyh	983	2	new	new	JJ
cord-270892-ycc3csyh	983	3	rapid	rapid	JJ
cord-270892-ycc3csyh	983	4	and	and	CC
cord-270892-ycc3csyh	983	5	effective	effective	JJ
cord-270892-ycc3csyh	983	6	chemistry	chemistry	NN
cord-270892-ycc3csyh	983	7	space	space	NN
cord-270892-ycc3csyh	983	8	filter	filter	NN
cord-270892-ycc3csyh	983	9	in	in	IN
cord-270892-ycc3csyh	983	10	recognizing	recognize	VBG
cord-270892-ycc3csyh	983	11	a	a	DT
cord-270892-ycc3csyh	983	12	druglike	druglike	NN
cord-270892-ycc3csyh	983	13	database	database	NN
cord-270892-ycc3csyh	983	14	Rational	rational	JJ
cord-270892-ycc3csyh	983	15	selection	selection	NN
cord-270892-ycc3csyh	983	16	of	of	IN
cord-270892-ycc3csyh	983	17	structurally	structurally	RB
cord-270892-ycc3csyh	983	18	diverse	diverse	JJ
cord-270892-ycc3csyh	983	19	natural	natural	JJ
cord-270892-ycc3csyh	983	20	product	product	NN
cord-270892-ycc3csyh	983	21	scaffolds	scaffold	NNS
cord-270892-ycc3csyh	983	22	with	with	IN
cord-270892-ycc3csyh	983	23	favorable	favorable	JJ
cord-270892-ycc3csyh	983	24	ADME	ADME	NNP
cord-270892-ycc3csyh	983	25	properties	property	NNS
cord-270892-ycc3csyh	983	26	for	for	IN
cord-270892-ycc3csyh	983	27	drug	drug	NN
cord-270892-ycc3csyh	983	28	discovery	discovery	NN
cord-270892-ycc3csyh	983	29	Natural	natural	JJ
cord-270892-ycc3csyh	983	30	products	product	NNS
cord-270892-ycc3csyh	983	31	as	as	IN
cord-270892-ycc3csyh	983	32	sources	source	NNS
cord-270892-ycc3csyh	983	33	of	of	IN
cord-270892-ycc3csyh	983	34	new	new	JJ
cord-270892-ycc3csyh	983	35	drugs	drug	NNS
cord-270892-ycc3csyh	983	36	over	over	IN
cord-270892-ycc3csyh	983	37	the	the	DT
cord-270892-ycc3csyh	983	38	last	last	JJ
cord-270892-ycc3csyh	983	39	25	25	CD
cord-270892-ycc3csyh	983	40	years	year	NNS
cord-270892-ycc3csyh	984	1	Ethnomedicinal	ethnomedicinal	JJ
cord-270892-ycc3csyh	984	2	antivirals	antiviral	NNS
cord-270892-ycc3csyh	984	3	:	:	:
cord-270892-ycc3csyh	985	1	Scope	scope	NN
cord-270892-ycc3csyh	985	2	and	and	CC
cord-270892-ycc3csyh	985	3	opportunity	opportunity	NN
cord-270892-ycc3csyh	985	4	Plant	plant	NN
cord-270892-ycc3csyh	985	5	substances	substance	NNS
cord-270892-ycc3csyh	985	6	as	as	IN
cord-270892-ycc3csyh	985	7	antiviral	antiviral	JJ
cord-270892-ycc3csyh	985	8	agents	agent	NNS
cord-270892-ycc3csyh	985	9	:	:	:
cord-270892-ycc3csyh	985	10	An	an	DT
cord-270892-ycc3csyh	985	11	update	update	NN
cord-270892-ycc3csyh	985	12	Plant	plant	NN
cord-270892-ycc3csyh	985	13	substances	substance	NNS
cord-270892-ycc3csyh	985	14	as	as	IN
cord-270892-ycc3csyh	985	15	antiviral	antiviral	JJ
cord-270892-ycc3csyh	985	16	agents	agent	NNS
cord-270892-ycc3csyh	985	17	Host	Host	NNP
cord-270892-ycc3csyh	985	18	defense	defense	NN
cord-270892-ycc3csyh	985	19	function	function	NN
cord-270892-ycc3csyh	985	20	of	of	IN
cord-270892-ycc3csyh	985	21	the	the	DT
cord-270892-ycc3csyh	985	22	airway	airway	NN
cord-270892-ycc3csyh	985	23	epithelium	epithelium	NN
cord-270892-ycc3csyh	985	24	in	in	IN
cord-270892-ycc3csyh	985	25	health	health	NN
cord-270892-ycc3csyh	985	26	and	and	CC
cord-270892-ycc3csyh	985	27	disease	disease	NN
cord-270892-ycc3csyh	985	28	:	:	:
cord-270892-ycc3csyh	986	1	Clinical	clinical	JJ
cord-270892-ycc3csyh	986	2	background	background	NN
cord-270892-ycc3csyh	986	3	Herb	Herb	NNP
cord-270892-ycc3csyh	986	4	sales	sale	NNS
cord-270892-ycc3csyh	986	5	down	down	RB
cord-270892-ycc3csyh	986	6	6	6	CD
cord-270892-ycc3csyh	986	7	percent	percent	NN
cord-270892-ycc3csyh	986	8	in	in	IN
cord-270892-ycc3csyh	986	9	mainstream	mainstream	NN
cord-270892-ycc3csyh	986	10	market	market	NN
cord-270892-ycc3csyh	986	11	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	986	12	for	for	IN
cord-270892-ycc3csyh	986	13	preventing	prevent	VBG
cord-270892-ycc3csyh	986	14	and	and	CC
cord-270892-ycc3csyh	986	15	treating	treat	VBG
cord-270892-ycc3csyh	986	16	the	the	DT
cord-270892-ycc3csyh	986	17	common	common	JJ
cord-270892-ycc3csyh	986	18	cold	cold	JJ
cord-270892-ycc3csyh	986	19	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	986	20	for	for	IN
cord-270892-ycc3csyh	986	21	preventing	prevent	VBG
cord-270892-ycc3csyh	986	22	and	and	CC
cord-270892-ycc3csyh	986	23	treating	treat	VBG
cord-270892-ycc3csyh	986	24	the	the	DT
cord-270892-ycc3csyh	986	25	common	common	JJ
cord-270892-ycc3csyh	986	26	cold	cold	NN
cord-270892-ycc3csyh	986	27	.	.	.
cord-270892-ycc3csyh	987	1	The	the	DT
cord-270892-ycc3csyh	987	2	Cochrane	Cochrane	NNP
cord-270892-ycc3csyh	987	3	Database	Database	NNP
cord-270892-ycc3csyh	987	4	of	of	IN
cord-270892-ycc3csyh	987	5	Systematic	Systematic	NNP
cord-270892-ycc3csyh	987	6	Reviews	Reviews	NNPS
cord-270892-ycc3csyh	987	7	Evaluation	Evaluation	NNP
cord-270892-ycc3csyh	987	8	of	of	IN
cord-270892-ycc3csyh	987	9	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	987	10	for	for	IN
cord-270892-ycc3csyh	987	11	the	the	DT
cord-270892-ycc3csyh	987	12	prevention	prevention	NN
cord-270892-ycc3csyh	987	13	and	and	CC
cord-270892-ycc3csyh	987	14	treatment	treatment	NN
cord-270892-ycc3csyh	987	15	of	of	IN
cord-270892-ycc3csyh	987	16	the	the	DT
cord-270892-ycc3csyh	987	17	common	common	JJ
cord-270892-ycc3csyh	987	18	cold	cold	NN
cord-270892-ycc3csyh	987	19	:	:	:
cord-270892-ycc3csyh	987	20	A	a	DT
cord-270892-ycc3csyh	987	21	meta	meta	JJ
cord-270892-ycc3csyh	987	22	-	-	HYPH
cord-270892-ycc3csyh	987	23	analysis	analysis	NN
cord-270892-ycc3csyh	987	24	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	987	25	in	in	IN
cord-270892-ycc3csyh	987	26	the	the	DT
cord-270892-ycc3csyh	987	27	prevention	prevention	NN
cord-270892-ycc3csyh	987	28	of	of	IN
cord-270892-ycc3csyh	987	29	induced	induce	VBN
cord-270892-ycc3csyh	987	30	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	987	31	colds	cold	NNS
cord-270892-ycc3csyh	987	32	:	:	:
cord-270892-ycc3csyh	987	33	A	a	DT
cord-270892-ycc3csyh	987	34	meta	meta	NN
cord-270892-ycc3csyh	987	35	-	-	HYPH
cord-270892-ycc3csyh	987	36	analysis	analysis	NN
cord-270892-ycc3csyh	987	37	The	the	DT
cord-270892-ycc3csyh	987	38	role	role	NN
cord-270892-ycc3csyh	987	39	of	of	IN
cord-270892-ycc3csyh	987	40	alkamides	alkamides	NNP
cord-270892-ycc3csyh	987	41	as	as	IN
cord-270892-ycc3csyh	987	42	an	an	DT
cord-270892-ycc3csyh	987	43	active	active	JJ
cord-270892-ycc3csyh	987	44	principle	principle	NN
cord-270892-ycc3csyh	987	45	of	of	IN
cord-270892-ycc3csyh	987	46	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	987	47	Alkylamides	Alkylamides	NNP
cord-270892-ycc3csyh	987	48	from	from	IN
cord-270892-ycc3csyh	987	49	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	987	50	are	be	VBP
cord-270892-ycc3csyh	987	51	a	a	DT
cord-270892-ycc3csyh	987	52	new	new	JJ
cord-270892-ycc3csyh	987	53	class	class	NN
cord-270892-ycc3csyh	987	54	of	of	IN
cord-270892-ycc3csyh	987	55	cannabinomimetics	cannabinomimetic	NNS
cord-270892-ycc3csyh	987	56	:	:	:
cord-270892-ycc3csyh	987	57	Cannabinoid	cannabinoid	NN
cord-270892-ycc3csyh	987	58	type	type	NN
cord-270892-ycc3csyh	987	59	2	2	CD
cord-270892-ycc3csyh	987	60	receptordependent	receptordependent	NN
cord-270892-ycc3csyh	987	61	and	and	CC
cord-270892-ycc3csyh	987	62	-independent	-independent	JJ
cord-270892-ycc3csyh	987	63	immunomodulatory	immunomodulatory	JJ
cord-270892-ycc3csyh	987	64	effects	effect	NNS
cord-270892-ycc3csyh	987	65	Synergistic	synergistic	JJ
cord-270892-ycc3csyh	987	66	anti	anti	JJ
cord-270892-ycc3csyh	987	67	-	-	JJ
cord-270892-ycc3csyh	987	68	oxidative	oxidative	JJ
cord-270892-ycc3csyh	987	69	effects	effect	NNS
cord-270892-ycc3csyh	987	70	of	of	IN
cord-270892-ycc3csyh	987	71	alkamides	alkamide	NNS
cord-270892-ycc3csyh	987	72	,	,	,
cord-270892-ycc3csyh	987	73	caffeic	caffeic	NN
cord-270892-ycc3csyh	987	74	acid	acid	NN
cord-270892-ycc3csyh	987	75	derivatives	derivative	NNS
cord-270892-ycc3csyh	987	76	,	,	,
cord-270892-ycc3csyh	987	77	and	and	CC
cord-270892-ycc3csyh	987	78	polysaccharide	polysaccharide	NN
cord-270892-ycc3csyh	987	79	fractions	fraction	NNS
cord-270892-ycc3csyh	987	80	from	from	IN
cord-270892-ycc3csyh	987	81	Echinacea	Echinacea	NNP
cord-270892-ycc3csyh	987	82	purpurea	purpurea	NN
cord-270892-ycc3csyh	987	83	on	on	IN
cord-270892-ycc3csyh	987	84	in	in	FW
cord-270892-ycc3csyh	987	85	vitro	vitro	FW
cord-270892-ycc3csyh	987	86	oxidation	oxidation	NN
cord-270892-ycc3csyh	987	87	of	of	IN
cord-270892-ycc3csyh	987	88	human	human	JJ
cord-270892-ycc3csyh	987	89	low	low	JJ
cord-270892-ycc3csyh	987	90	-	-	HYPH
cord-270892-ycc3csyh	987	91	density	density	NN
cord-270892-ycc3csyh	987	92	lipoproteins	lipoprotein	NNS
cord-270892-ycc3csyh	987	93	Echinacea	echinacea	NN
cord-270892-ycc3csyh	987	94	extracts	extract	NNS
cord-270892-ycc3csyh	987	95	modulate	modulate	VBP
cord-270892-ycc3csyh	987	96	the	the	DT
cord-270892-ycc3csyh	987	97	pattern	pattern	NN
cord-270892-ycc3csyh	987	98	of	of	IN
cord-270892-ycc3csyh	987	99	chemokine	chemokine	NN
cord-270892-ycc3csyh	987	100	and	and	CC
cord-270892-ycc3csyh	987	101	cytokine	cytokine	JJ
cord-270892-ycc3csyh	987	102	secretion	secretion	NN
cord-270892-ycc3csyh	987	103	in	in	IN
cord-270892-ycc3csyh	987	104	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	987	105	-	-	HYPH
cord-270892-ycc3csyh	987	106	infected	infect	VBN
cord-270892-ycc3csyh	987	107	and	and	CC
cord-270892-ycc3csyh	987	108	uninfected	uninfected	JJ
cord-270892-ycc3csyh	987	109	epithelial	epithelial	JJ
cord-270892-ycc3csyh	987	110	cells	cell	NNS
cord-270892-ycc3csyh	987	111	Modulation	modulation	NN
cord-270892-ycc3csyh	987	112	of	of	IN
cord-270892-ycc3csyh	987	113	immune	immune	JJ
cord-270892-ycc3csyh	987	114	response	response	NN
cord-270892-ycc3csyh	987	115	gene	gene	NN
cord-270892-ycc3csyh	987	116	expression	expression	NN
cord-270892-ycc3csyh	987	117	by	by	IN
cord-270892-ycc3csyh	987	118	echinacea	echinacea	JJ
cord-270892-ycc3csyh	987	119	extracts	extract	NNS
cord-270892-ycc3csyh	987	120	:	:	:
cord-270892-ycc3csyh	987	121	Results	result	NNS
cord-270892-ycc3csyh	987	122	of	of	IN
cord-270892-ycc3csyh	987	123	a	a	DT
cord-270892-ycc3csyh	987	124	gene	gene	NN
cord-270892-ycc3csyh	987	125	array	array	NN
cord-270892-ycc3csyh	987	126	analysis	analysis	NN
cord-270892-ycc3csyh	987	127	Preventing	prevent	VBG
cord-270892-ycc3csyh	987	128	the	the	DT
cord-270892-ycc3csyh	987	129	common	common	JJ
cord-270892-ycc3csyh	987	130	cold	cold	NN
cord-270892-ycc3csyh	987	131	with	with	IN
cord-270892-ycc3csyh	987	132	a	a	DT
cord-270892-ycc3csyh	987	133	garlic	garlic	NN
cord-270892-ycc3csyh	987	134	supplement	supplement	NN
cord-270892-ycc3csyh	987	135	:	:	:
cord-270892-ycc3csyh	987	136	A	a	DT
cord-270892-ycc3csyh	987	137	double	double	JJ
cord-270892-ycc3csyh	987	138	-	-	HYPH
cord-270892-ycc3csyh	987	139	blind	blind	JJ
cord-270892-ycc3csyh	987	140	,	,	,
cord-270892-ycc3csyh	987	141	placebocontrolled	placebocontrolled	JJ
cord-270892-ycc3csyh	987	142	survey	survey	NN
cord-270892-ycc3csyh	988	1	In	in	IN
cord-270892-ycc3csyh	988	2	vitro	vitro	FW
cord-270892-ycc3csyh	988	3	virucidal	virucidal	JJ
cord-270892-ycc3csyh	988	4	effects	effect	NNS
cord-270892-ycc3csyh	988	5	of	of	IN
cord-270892-ycc3csyh	988	6	Allium	allium	NN
cord-270892-ycc3csyh	988	7	sativum	sativum	NNP
cord-270892-ycc3csyh	988	8	(	(	-LRB-
cord-270892-ycc3csyh	988	9	garlic	garlic	NNP
cord-270892-ycc3csyh	988	10	)	)	-RRB-
cord-270892-ycc3csyh	988	11	extract	extract	NN
cord-270892-ycc3csyh	988	12	and	and	CC
cord-270892-ycc3csyh	988	13	compounds	compound	NNS
cord-270892-ycc3csyh	988	14	Enhancement	Enhancement	NNP
cord-270892-ycc3csyh	988	15	of	of	IN
cord-270892-ycc3csyh	988	16	in	in	IN
cord-270892-ycc3csyh	988	17	vitro	vitro	FW
cord-270892-ycc3csyh	988	18	human	human	JJ
cord-270892-ycc3csyh	988	19	immune	immune	JJ
cord-270892-ycc3csyh	988	20	function	function	NN
cord-270892-ycc3csyh	988	21	by	by	IN
cord-270892-ycc3csyh	988	22	Allium	Allium	NNP
cord-270892-ycc3csyh	988	23	sativum	sativum	NNP
cord-270892-ycc3csyh	988	24	L.	L.	NNP
cord-270892-ycc3csyh	988	25	(	(	-LRB-
cord-270892-ycc3csyh	988	26	garlic	garlic	NNP
cord-270892-ycc3csyh	988	27	)	)	-RRB-
cord-270892-ycc3csyh	988	28	fractions	fraction	NNS
cord-270892-ycc3csyh	988	29	Efficacy	Efficacy	NNP
cord-270892-ycc3csyh	988	30	of	of	IN
cord-270892-ycc3csyh	988	31	COLD	COLD	NNP
cord-270892-ycc3csyh	988	32	-	-	HYPH
cord-270892-ycc3csyh	988	33	fX	fx	NN
cord-270892-ycc3csyh	988	34	in	in	IN
cord-270892-ycc3csyh	988	35	the	the	DT
cord-270892-ycc3csyh	988	36	prevention	prevention	NN
cord-270892-ycc3csyh	988	37	of	of	IN
cord-270892-ycc3csyh	988	38	respiratory	respiratory	JJ
cord-270892-ycc3csyh	988	39	symptoms	symptom	NNS
cord-270892-ycc3csyh	988	40	in	in	IN
cord-270892-ycc3csyh	988	41	community	community	NN
cord-270892-ycc3csyh	988	42	-	-	HYPH
cord-270892-ycc3csyh	988	43	dwelling	dwell	VBG
cord-270892-ycc3csyh	988	44	adults	adult	NNS
cord-270892-ycc3csyh	988	45	:	:	:
cord-270892-ycc3csyh	988	46	A	a	DT
cord-270892-ycc3csyh	988	47	randomized	randomized	JJ
cord-270892-ycc3csyh	988	48	,	,	,
cord-270892-ycc3csyh	988	49	doubleblinded	doubleblinded	JJ
cord-270892-ycc3csyh	988	50	,	,	,
cord-270892-ycc3csyh	988	51	placebo	placebo	NN
cord-270892-ycc3csyh	988	52	controlled	control	VBN
cord-270892-ycc3csyh	988	53	trial	trial	NN
cord-270892-ycc3csyh	988	54	Efficacy	Efficacy	NNP
cord-270892-ycc3csyh	988	55	of	of	IN
cord-270892-ycc3csyh	988	56	an	an	DT
cord-270892-ycc3csyh	988	57	extract	extract	NN
cord-270892-ycc3csyh	988	58	of	of	IN
cord-270892-ycc3csyh	988	59	North	north	JJ
cord-270892-ycc3csyh	988	60	American	american	JJ
cord-270892-ycc3csyh	988	61	ginseng	ginseng	NN
cord-270892-ycc3csyh	988	62	containing	contain	VBG
cord-270892-ycc3csyh	988	63	poly	poly	JJ
cord-270892-ycc3csyh	988	64	-	-	HYPH
cord-270892-ycc3csyh	988	65	furanosyl	furanosyl	NN
cord-270892-ycc3csyh	988	66	-	-	HYPH
cord-270892-ycc3csyh	988	67	pyranosyl	pyranosyl	NN
cord-270892-ycc3csyh	988	68	-	-	HYPH
cord-270892-ycc3csyh	988	69	saccharides	saccharide	NNS
cord-270892-ycc3csyh	988	70	for	for	IN
cord-270892-ycc3csyh	988	71	preventing	prevent	VBG
cord-270892-ycc3csyh	988	72	upper	upper	JJ
cord-270892-ycc3csyh	988	73	respiratory	respiratory	JJ
cord-270892-ycc3csyh	988	74	tract	tract	NN
cord-270892-ycc3csyh	988	75	infections	infection	NNS
cord-270892-ycc3csyh	988	76	:	:	:
cord-270892-ycc3csyh	988	77	A	a	DT
cord-270892-ycc3csyh	988	78	randomized	randomized	JJ
cord-270892-ycc3csyh	988	79	controlled	control	VBN
cord-270892-ycc3csyh	988	80	trial	trial	NN
cord-270892-ycc3csyh	988	81	Safety	safety	NN
cord-270892-ycc3csyh	988	82	and	and	CC
cord-270892-ycc3csyh	988	83	tolerability	tolerability	NN
cord-270892-ycc3csyh	988	84	of	of	IN
cord-270892-ycc3csyh	988	85	North	north	JJ
cord-270892-ycc3csyh	988	86	American	american	JJ
cord-270892-ycc3csyh	988	87	ginseng	ginseng	NN
cord-270892-ycc3csyh	988	88	extract	extract	NN
cord-270892-ycc3csyh	988	89	in	in	IN
cord-270892-ycc3csyh	988	90	the	the	DT
cord-270892-ycc3csyh	988	91	treatment	treatment	NN
cord-270892-ycc3csyh	988	92	of	of	IN
cord-270892-ycc3csyh	988	93	pediatric	pediatric	JJ
cord-270892-ycc3csyh	988	94	upper	upper	JJ
cord-270892-ycc3csyh	988	95	respiratory	respiratory	JJ
cord-270892-ycc3csyh	988	96	tract	tract	NN
cord-270892-ycc3csyh	988	97	infection	infection	NN
cord-270892-ycc3csyh	988	98	:	:	:
cord-270892-ycc3csyh	988	99	A	a	DT
cord-270892-ycc3csyh	988	100	phase	phase	NN
cord-270892-ycc3csyh	988	101	II	ii	CD
cord-270892-ycc3csyh	988	102	randomized	randomized	JJ
cord-270892-ycc3csyh	988	103	,	,	,
cord-270892-ycc3csyh	988	104	controlled	control	VBN
cord-270892-ycc3csyh	988	105	trial	trial	NN
cord-270892-ycc3csyh	988	106	of	of	IN
cord-270892-ycc3csyh	988	107	2	2	CD
cord-270892-ycc3csyh	988	108	dosing	dosing	NN
cord-270892-ycc3csyh	988	109	schedules	schedule	NNS
cord-270892-ycc3csyh	988	110	Inhibitory	inhibitory	JJ
cord-270892-ycc3csyh	988	111	effect	effect	NN
cord-270892-ycc3csyh	988	112	of	of	IN
cord-270892-ycc3csyh	988	113	ginsenoside	ginsenoside	NN
cord-270892-ycc3csyh	988	114	Rg3	Rg3	NNP
cord-270892-ycc3csyh	988	115	and	and	CC
cord-270892-ycc3csyh	988	116	its	-PRON-	PRP$
cord-270892-ycc3csyh	988	117	derivative	derivative	JJ
cord-270892-ycc3csyh	988	118	ginsenoside	ginsenoside	NN
cord-270892-ycc3csyh	988	119	Rg3	rg3	NN
cord-270892-ycc3csyh	988	120	-	-	HYPH
cord-270892-ycc3csyh	988	121	2H	2h	NN
cord-270892-ycc3csyh	988	122	on	on	IN
cord-270892-ycc3csyh	988	123	NO	no	DT
cord-270892-ycc3csyh	988	124	production	production	NN
cord-270892-ycc3csyh	988	125	and	and	CC
cord-270892-ycc3csyh	988	126	lymphocyte	lymphocyte	NN
cord-270892-ycc3csyh	988	127	proliferation	proliferation	NN
cord-270892-ycc3csyh	988	128	Effect	effect	NN
cord-270892-ycc3csyh	988	129	of	of	IN
cord-270892-ycc3csyh	988	130	CVT	cvt	NN
cord-270892-ycc3csyh	988	131	-	-	HYPH
cord-270892-ycc3csyh	988	132	E002	E002	NNP
cord-270892-ycc3csyh	988	133	(	(	-LRB-
cord-270892-ycc3csyh	988	134	COLD	COLD	NNP
cord-270892-ycc3csyh	988	135	-	-	HYPH
cord-270892-ycc3csyh	988	136	fX	fX	NNP
cord-270892-ycc3csyh	988	137	)	)	-RRB-
cord-270892-ycc3csyh	988	138	versus	versus	IN
cord-270892-ycc3csyh	988	139	a	a	DT
cord-270892-ycc3csyh	988	140	ginsenoside	ginsenoside	NN
cord-270892-ycc3csyh	988	141	extract	extract	NN
cord-270892-ycc3csyh	988	142	on	on	IN
cord-270892-ycc3csyh	988	143	systemic	systemic	JJ
cord-270892-ycc3csyh	988	144	and	and	CC
cord-270892-ycc3csyh	988	145	gut	gut	NN
cord-270892-ycc3csyh	988	146	-	-	HYPH
cord-270892-ycc3csyh	988	147	associated	associate	VBN
cord-270892-ycc3csyh	988	148	immune	immune	JJ
cord-270892-ycc3csyh	988	149	function	function	NN
cord-270892-ycc3csyh	988	150	Inhibitory	inhibitory	JJ
cord-270892-ycc3csyh	988	151	effect	effect	NN
cord-270892-ycc3csyh	988	152	of	of	IN
cord-270892-ycc3csyh	988	153	ginseng	ginseng	NN
cord-270892-ycc3csyh	988	154	polysaccharides	polysaccharide	NNS
cord-270892-ycc3csyh	988	155	on	on	IN
cord-270892-ycc3csyh	988	156	rotavirus	rotavirus	JJ
cord-270892-ycc3csyh	988	157	infection	infection	NN
cord-270892-ycc3csyh	988	158	Antiviral	antiviral	JJ
cord-270892-ycc3csyh	988	159	activity	activity	NN
cord-270892-ycc3csyh	988	160	of	of	IN
cord-270892-ycc3csyh	988	161	dammarane	dammarane	NN
cord-270892-ycc3csyh	988	162	saponins	saponin	NNS
cord-270892-ycc3csyh	988	163	against	against	IN
cord-270892-ycc3csyh	988	164	herpes	herpes	NNP
cord-270892-ycc3csyh	988	165	simplex	simplex	NNP
cord-270892-ycc3csyh	988	166	virus	virus	NN
cord-270892-ycc3csyh	989	1	I	-PRON-	PRP
cord-270892-ycc3csyh	989	2	Effect	effect	VBP
cord-270892-ycc3csyh	989	3	of	of	IN
cord-270892-ycc3csyh	989	4	a	a	DT
cord-270892-ycc3csyh	989	5	traditional	traditional	JJ
cord-270892-ycc3csyh	989	6	Japanese	japanese	JJ
cord-270892-ycc3csyh	989	7	herbal	herbal	JJ
cord-270892-ycc3csyh	989	8	medicine	medicine	NN
cord-270892-ycc3csyh	989	9	,	,	,
cord-270892-ycc3csyh	989	10	Hochu	Hochu	NNP
cord-270892-ycc3csyh	989	11	-	-	HYPH
cord-270892-ycc3csyh	989	12	ekki	ekki	NNP
cord-270892-ycc3csyh	989	13	-	-	HYPH
cord-270892-ycc3csyh	989	14	to	to	IN
cord-270892-ycc3csyh	989	15	(	(	-LRB-
cord-270892-ycc3csyh	989	16	Bu	Bu	NNP
cord-270892-ycc3csyh	989	17	-	-	HYPH
cord-270892-ycc3csyh	989	18	Zhong	Zhong	NNP
cord-270892-ycc3csyh	989	19	-	-	HYPH
cord-270892-ycc3csyh	989	20	Yi	Yi	NNP
cord-270892-ycc3csyh	989	21	-	-	HYPH
cord-270892-ycc3csyh	989	22	Qi	Qi	NNP
cord-270892-ycc3csyh	989	23	Tang	Tang	NNP
cord-270892-ycc3csyh	989	24	)	)	-RRB-
cord-270892-ycc3csyh	989	25	,	,	,
cord-270892-ycc3csyh	989	26	on	on	IN
cord-270892-ycc3csyh	989	27	immunity	immunity	NN
cord-270892-ycc3csyh	989	28	in	in	IN
cord-270892-ycc3csyh	989	29	elderly	elderly	JJ
cord-270892-ycc3csyh	989	30	persons	person	NNS
cord-270892-ycc3csyh	989	31	Effects	effect	NNS
cord-270892-ycc3csyh	989	32	of	of	IN
cord-270892-ycc3csyh	989	33	five	five	CD
cord-270892-ycc3csyh	989	34	kampohozais	kampohozai	NNS
cord-270892-ycc3csyh	989	35	on	on	IN
cord-270892-ycc3csyh	989	36	the	the	DT
cord-270892-ycc3csyh	989	37	mitogenic	mitogenic	NNP
cord-270892-ycc3csyh	989	38	activity	activity	NN
cord-270892-ycc3csyh	989	39	of	of	IN
cord-270892-ycc3csyh	989	40	lipopolysaccharide	lipopolysaccharide	NN
cord-270892-ycc3csyh	989	41	,	,	,
cord-270892-ycc3csyh	989	42	concanavalin	concanavalin	NNP
cord-270892-ycc3csyh	989	43	A	A	NNP
cord-270892-ycc3csyh	989	44	,	,	,
cord-270892-ycc3csyh	989	45	phorbol	phorbol	NNP
cord-270892-ycc3csyh	989	46	myristate	myristate	NNP
cord-270892-ycc3csyh	989	47	acetate	acetate	NNP
cord-270892-ycc3csyh	989	48	and	and	CC
cord-270892-ycc3csyh	989	49	phytohemagglutinin	phytohemagglutinin	NNS
cord-270892-ycc3csyh	989	50	in	in	IN
cord-270892-ycc3csyh	989	51	vivo	vivo	NN
cord-270892-ycc3csyh	989	52	Immunological	immunological	JJ
cord-270892-ycc3csyh	989	53	restoration	restoration	NN
cord-270892-ycc3csyh	989	54	and	and	CC
cord-270892-ycc3csyh	989	55	anti	anti	JJ
cord-270892-ycc3csyh	989	56	-	-	JJ
cord-270892-ycc3csyh	989	57	tumor	tumor	JJ
cord-270892-ycc3csyh	989	58	effect	effect	NN
cord-270892-ycc3csyh	989	59	by	by	IN
cord-270892-ycc3csyh	989	60	Japanese	japanese	JJ
cord-270892-ycc3csyh	989	61	herbal	herbal	JJ
cord-270892-ycc3csyh	989	62	medicine	medicine	NN
cord-270892-ycc3csyh	989	63	in	in	IN
cord-270892-ycc3csyh	989	64	aged	aged	JJ
cord-270892-ycc3csyh	989	65	mice	mouse	NNS
cord-270892-ycc3csyh	990	1	Antiinflammatory	antiinflammatory	JJ
cord-270892-ycc3csyh	990	2	effects	effect	NNS
cord-270892-ycc3csyh	990	3	of	of	IN
cord-270892-ycc3csyh	990	4	Bu	Bu	NNP
cord-270892-ycc3csyh	990	5	-	-	HYPH
cord-270892-ycc3csyh	990	6	zhong	zhong	NNP
cord-270892-ycc3csyh	990	7	-	-	HYPH
cord-270892-ycc3csyh	990	8	yi	yi	NNP
cord-270892-ycc3csyh	990	9	-	-	HYPH
cord-270892-ycc3csyh	990	10	qi	qi	NNP
cord-270892-ycc3csyh	990	11	-	-	HYPH
cord-270892-ycc3csyh	990	12	tang	tang	NNP
cord-270892-ycc3csyh	990	13	in	in	IN
cord-270892-ycc3csyh	990	14	patients	patient	NNS
cord-270892-ycc3csyh	990	15	with	with	IN
cord-270892-ycc3csyh	990	16	perennial	perennial	JJ
cord-270892-ycc3csyh	990	17	allergic	allergic	JJ
cord-270892-ycc3csyh	990	18	rhinitis	rhinitis	NN
cord-270892-ycc3csyh	990	19	Hochu	Hochu	NNP
cord-270892-ycc3csyh	990	20	-	-	HYPH
cord-270892-ycc3csyh	990	21	ekki-	ekki-	JJ
cord-270892-ycc3csyh	991	1	to	to	TO
cord-270892-ycc3csyh	991	2	inhibits	inhibits	VB
cord-270892-ycc3csyh	991	3	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	991	4	infection	infection	NN
cord-270892-ycc3csyh	991	5	in	in	IN
cord-270892-ycc3csyh	991	6	human	human	JJ
cord-270892-ycc3csyh	991	7	tracheal	tracheal	NN
cord-270892-ycc3csyh	991	8	epithelial	epithelial	NN
cord-270892-ycc3csyh	991	9	cells	cell	NNS
cord-270892-ycc3csyh	991	10	Efficacy	Efficacy	NNP
cord-270892-ycc3csyh	991	11	of	of	IN
cord-270892-ycc3csyh	991	12	a	a	DT
cord-270892-ycc3csyh	991	13	pelargonium	pelargonium	NN
cord-270892-ycc3csyh	991	14	sidoides	sidoide	NNS
cord-270892-ycc3csyh	991	15	preparation	preparation	NN
cord-270892-ycc3csyh	991	16	in	in	IN
cord-270892-ycc3csyh	991	17	patients	patient	NNS
cord-270892-ycc3csyh	991	18	with	with	IN
cord-270892-ycc3csyh	991	19	the	the	DT
cord-270892-ycc3csyh	991	20	common	common	JJ
cord-270892-ycc3csyh	991	21	cold	cold	NN
cord-270892-ycc3csyh	991	22	:	:	:
cord-270892-ycc3csyh	992	1	A	a	DT
cord-270892-ycc3csyh	992	2	randomized	randomized	JJ
cord-270892-ycc3csyh	992	3	,	,	,
cord-270892-ycc3csyh	992	4	double	double	JJ
cord-270892-ycc3csyh	992	5	blind	blind	JJ
cord-270892-ycc3csyh	992	6	,	,	,
cord-270892-ycc3csyh	992	7	placebo	placebo	NN
cord-270892-ycc3csyh	992	8	-	-	HYPH
cord-270892-ycc3csyh	992	9	controlled	control	VBN
cord-270892-ycc3csyh	992	10	clinical	clinical	JJ
cord-270892-ycc3csyh	992	11	trial	trial	NN
cord-270892-ycc3csyh	992	12	Kern	Kern	NNP
cord-270892-ycc3csyh	992	13	Winfried	Winfried	NNP
cord-270892-ycc3csyh	992	14	V.	V.	NNP
cord-270892-ycc3csyh	992	15	Pelargonium	Pelargonium	NNP
cord-270892-ycc3csyh	992	16	sidoides	sidoide	NNS
cord-270892-ycc3csyh	992	17	extract	extract	VBP
cord-270892-ycc3csyh	992	18	for	for	IN
cord-270892-ycc3csyh	992	19	acute	acute	JJ
cord-270892-ycc3csyh	992	20	respiratory	respiratory	JJ
cord-270892-ycc3csyh	992	21	tract	tract	NN
cord-270892-ycc3csyh	992	22	infections	infection	NNS
cord-270892-ycc3csyh	992	23	Traditionally	traditionally	RB
cord-270892-ycc3csyh	992	24	used	use	VBN
cord-270892-ycc3csyh	992	25	pelargonium	pelargonium	NN
cord-270892-ycc3csyh	992	26	species	specie	NNS
cord-270892-ycc3csyh	992	27	:	:	:
cord-270892-ycc3csyh	992	28	Chemistry	chemistry	NN
cord-270892-ycc3csyh	992	29	and	and	CC
cord-270892-ycc3csyh	992	30	biological	biological	JJ
cord-270892-ycc3csyh	992	31	activity	activity	NN
cord-270892-ycc3csyh	992	32	of	of	IN
cord-270892-ycc3csyh	992	33	umckaloabo	umckaloabo	NNS
cord-270892-ycc3csyh	992	34	extracts	extract	NNS
cord-270892-ycc3csyh	992	35	and	and	CC
cord-270892-ycc3csyh	992	36	their	-PRON-	PRP$
cord-270892-ycc3csyh	992	37	constituents	constituent	NNS
cord-270892-ycc3csyh	993	1	Aqueous	aqueous	JJ
cord-270892-ycc3csyh	993	2	ethanolic	ethanolic	JJ
cord-270892-ycc3csyh	993	3	extract	extract	NN
cord-270892-ycc3csyh	993	4	of	of	IN
cord-270892-ycc3csyh	993	5	the	the	DT
cord-270892-ycc3csyh	993	6	roots	root	NNS
cord-270892-ycc3csyh	993	7	of	of	IN
cord-270892-ycc3csyh	993	8	Pelargonium	Pelargonium	NNP
cord-270892-ycc3csyh	993	9	sidoides	sidoide	NNS
cord-270892-ycc3csyh	993	10	-	-	:
cord-270892-ycc3csyh	993	11	New	new	JJ
cord-270892-ycc3csyh	993	12	scientific	scientific	JJ
cord-270892-ycc3csyh	993	13	evidence	evidence	NN
cord-270892-ycc3csyh	993	14	for	for	IN
cord-270892-ycc3csyh	993	15	an	an	DT
cord-270892-ycc3csyh	993	16	old	old	JJ
cord-270892-ycc3csyh	993	17	anti	anti	JJ
cord-270892-ycc3csyh	993	18	-	-	JJ
cord-270892-ycc3csyh	993	19	infective	infective	JJ
cord-270892-ycc3csyh	993	20	phytopharmaceutical	phytopharmaceutical	JJ
cord-270892-ycc3csyh	993	21	Efficacy	Efficacy	NNP
cord-270892-ycc3csyh	993	22	of	of	IN
cord-270892-ycc3csyh	993	23	an	an	DT
cord-270892-ycc3csyh	993	24	aqueous	aqueous	JJ
cord-270892-ycc3csyh	993	25	Pelargonium	Pelargonium	NNP
cord-270892-ycc3csyh	993	26	sidoides	sidoide	NNS
cord-270892-ycc3csyh	993	27	extract	extract	NN
cord-270892-ycc3csyh	993	28	against	against	IN
cord-270892-ycc3csyh	993	29	herpesvirus	herpesvirus	NN
cord-270892-ycc3csyh	993	30	Protective	protective	JJ
cord-270892-ycc3csyh	993	31	effect	effect	NN
cord-270892-ycc3csyh	993	32	of	of	IN
cord-270892-ycc3csyh	993	33	a	a	DT
cord-270892-ycc3csyh	993	34	natural	natural	JJ
cord-270892-ycc3csyh	993	35	carrageenan	carrageenan	NN
cord-270892-ycc3csyh	993	36	on	on	IN
cord-270892-ycc3csyh	993	37	genital	genital	JJ
cord-270892-ycc3csyh	993	38	herpes	herpes	NN
cord-270892-ycc3csyh	993	39	simplex	simplex	NN
cord-270892-ycc3csyh	993	40	virus	virus	NN
cord-270892-ycc3csyh	993	41	infection	infection	NN
cord-270892-ycc3csyh	993	42	in	in	IN
cord-270892-ycc3csyh	993	43	mice	mouse	NNS
cord-270892-ycc3csyh	993	44	Polysaccharides	Polysaccharides	NNP
cord-270892-ycc3csyh	993	45	as	as	IN
cord-270892-ycc3csyh	993	46	antiviral	antiviral	JJ
cord-270892-ycc3csyh	993	47	agents	agent	NNS
cord-270892-ycc3csyh	993	48	:	:	:
cord-270892-ycc3csyh	994	1	Antiviral	antiviral	JJ
cord-270892-ycc3csyh	994	2	activity	activity	NN
cord-270892-ycc3csyh	994	3	of	of	IN
cord-270892-ycc3csyh	994	4	carrageenan	carrageenan	NN
cord-270892-ycc3csyh	994	5	Iota	Iota	NNP
cord-270892-ycc3csyh	994	6	-	-	HYPH
cord-270892-ycc3csyh	994	7	Carrageenan	Carrageenan	NNP
cord-270892-ycc3csyh	994	8	is	be	VBZ
cord-270892-ycc3csyh	994	9	a	a	DT
cord-270892-ycc3csyh	994	10	potent	potent	JJ
cord-270892-ycc3csyh	994	11	inhibitor	inhibitor	NN
cord-270892-ycc3csyh	994	12	of	of	IN
cord-270892-ycc3csyh	994	13	rhinovirus	rhinovirus	JJ
cord-270892-ycc3csyh	994	14	infection	infection	NN
cord-270892-ycc3csyh	994	15	Recommendations	Recommendations	NNPS
cord-270892-ycc3csyh	994	16	for	for	IN
cord-270892-ycc3csyh	994	17	reporting	report	VBG
cord-270892-ycc3csyh	994	18	randomized	randomized	JJ
cord-270892-ycc3csyh	994	19	controlled	control	VBN
cord-270892-ycc3csyh	994	20	trials	trial	NNS
cord-270892-ycc3csyh	994	21	of	of	IN
cord-270892-ycc3csyh	994	22	herbal	herbal	JJ
cord-270892-ycc3csyh	994	23	interventions	intervention	NNS
cord-270892-ycc3csyh	994	24	:	:	:
cord-270892-ycc3csyh	995	1	Explanation	explanation	NN
cord-270892-ycc3csyh	995	2	and	and	CC
cord-270892-ycc3csyh	995	3	elaboration	elaboration	NN
cord-270892-ycc3csyh	995	4	Ethnobotany	Ethnobotany	NNP
cord-270892-ycc3csyh	995	5	and	and	CC
cord-270892-ycc3csyh	995	6	the	the	DT
cord-270892-ycc3csyh	995	7	search	search	NN
cord-270892-ycc3csyh	995	8	for	for	IN
cord-270892-ycc3csyh	995	9	new	new	JJ
cord-270892-ycc3csyh	995	10	drugs	drug	NNS
cord-270892-ycc3csyh	995	11	:	:	:
cord-270892-ycc3csyh	995	12	Ciba	Ciba	NNP
cord-270892-ycc3csyh	995	13	Foundation	Foundation	NNP
cord-270892-ycc3csyh	995	14	Symposium	Symposium	NNP
cord-270892-ycc3csyh	995	15	185	185	CD
cord-270892-ycc3csyh	995	16	Ethnobotany	Ethnobotany	NNP
cord-270892-ycc3csyh	995	17	and	and	CC
cord-270892-ycc3csyh	995	18	natural	natural	JJ
cord-270892-ycc3csyh	995	19	products	product	NNS
cord-270892-ycc3csyh	995	20	:	:	:
cord-270892-ycc3csyh	995	21	The	the	DT
cord-270892-ycc3csyh	995	22	search	search	NN
cord-270892-ycc3csyh	995	23	for	for	IN
cord-270892-ycc3csyh	995	24	new	new	JJ
cord-270892-ycc3csyh	995	25	molecules	molecule	NNS
cord-270892-ycc3csyh	995	26	,	,	,
cord-270892-ycc3csyh	995	27	new	new	JJ
cord-270892-ycc3csyh	995	28	treatments	treatment	NNS
cord-270892-ycc3csyh	995	29	of	of	IN
cord-270892-ycc3csyh	995	30	old	old	JJ
cord-270892-ycc3csyh	995	31	diseases	disease	NNS
cord-270892-ycc3csyh	995	32	or	or	CC
cord-270892-ycc3csyh	995	33	a	a	DT
cord-270892-ycc3csyh	995	34	better	well	JJR
cord-270892-ycc3csyh	995	35	understanding	understanding	NN
cord-270892-ycc3csyh	995	36	of	of	IN
cord-270892-ycc3csyh	995	37	indigenous	indigenous	JJ
cord-270892-ycc3csyh	995	38	cultures	culture	NNS
cord-270892-ycc3csyh	995	39	?	?	.
cord-270892-ycc3csyh	996	1	How	how	WRB
cord-270892-ycc3csyh	996	2	scientific	scientific	JJ
cord-270892-ycc3csyh	996	3	is	be	VBZ
cord-270892-ycc3csyh	996	4	the	the	DT
cord-270892-ycc3csyh	996	5	science	science	NN
cord-270892-ycc3csyh	996	6	in	in	IN
cord-270892-ycc3csyh	996	7	ethnopharmacology	ethnopharmacology	NNP
cord-270892-ycc3csyh	996	8	?	?	.
cord-270892-ycc3csyh	997	1	Historical	historical	JJ
cord-270892-ycc3csyh	997	2	perspectives	perspective	NNS
cord-270892-ycc3csyh	997	3	and	and	CC
cord-270892-ycc3csyh	997	4	epistemological	epistemological	JJ
cord-270892-ycc3csyh	997	5	problems	problem	NNS
cord-270892-ycc3csyh	997	6	Pedanius	Pedanius	NNP
cord-270892-ycc3csyh	997	7	Dioscorides	Dioscorides	NNP
cord-270892-ycc3csyh	997	8	of	of	IN
cord-270892-ycc3csyh	997	9	Anazarbus	Anazarbus	NNP
cord-270892-ycc3csyh	997	10	-	-	HYPH
cord-270892-ycc3csyh	997	11	De	De	NNP
cord-270892-ycc3csyh	997	12	materia	materia	FW
cord-270892-ycc3csyh	997	13	medica	medica	FW
cord-270892-ycc3csyh	997	14	Sesquiterpene	sesquiterpene	JJ
cord-270892-ycc3csyh	997	15	coumarins	coumarin	NNS
cord-270892-ycc3csyh	997	16	from	from	IN
cord-270892-ycc3csyh	997	17	Ferula	Ferula	NNP
cord-270892-ycc3csyh	997	18	assafoetida	assafoetida	NNP
cord-270892-ycc3csyh	997	19	L	L	NNP
cord-270892-ycc3csyh	997	20	Antiviral	Antiviral	NNP
cord-270892-ycc3csyh	997	21	flavonoid	flavonoid	NN
cord-270892-ycc3csyh	997	22	from	from	IN
cord-270892-ycc3csyh	997	23	Pterocaulon	Pterocaulon	NNP
cord-270892-ycc3csyh	997	24	sphacelatum	sphacelatum	NNP
cord-270892-ycc3csyh	997	25	,	,	,
cord-270892-ycc3csyh	997	26	an	an	DT
cord-270892-ycc3csyh	997	27	Australian	australian	JJ
cord-270892-ycc3csyh	997	28	Aboriginal	aboriginal	JJ
cord-270892-ycc3csyh	997	29	medicine	medicine	NN
cord-270892-ycc3csyh	997	30	In	in	IN
cord-270892-ycc3csyh	997	31	silico	silico	NN
cord-270892-ycc3csyh	997	32	target	target	NN
cord-270892-ycc3csyh	997	33	fishing	fishing	NN
cord-270892-ycc3csyh	997	34	for	for	IN
cord-270892-ycc3csyh	997	35	rationalized	rationalized	JJ
cord-270892-ycc3csyh	997	36	ligand	ligand	NN
cord-270892-ycc3csyh	997	37	discovery	discovery	NN
cord-270892-ycc3csyh	997	38	exemplified	exemplify	VBN
cord-270892-ycc3csyh	997	39	on	on	IN
cord-270892-ycc3csyh	997	40	constituents	constituent	NNS
cord-270892-ycc3csyh	997	41	of	of	IN
cord-270892-ycc3csyh	997	42	Ruta	Ruta	NNP
cord-270892-ycc3csyh	997	43	graveolens	graveolens	NNP
cord-270892-ycc3csyh	997	44	L	L	NNP
cord-270892-ycc3csyh	997	45	Antiviral	Antiviral	NNP
cord-270892-ycc3csyh	997	46	activity	activity	NN
cord-270892-ycc3csyh	997	47	of	of	IN
cord-270892-ycc3csyh	997	48	natural	natural	JJ
cord-270892-ycc3csyh	997	49	occurring	occur	VBG
cord-270892-ycc3csyh	997	50	flavonoids	flavonoid	NNS
cord-270892-ycc3csyh	997	51	in	in	IN
cord-270892-ycc3csyh	997	52	vitro	vitro	FW
cord-270892-ycc3csyh	997	53	Antiviral	antiviral	JJ
cord-270892-ycc3csyh	997	54	agents	agent	NNS
cord-270892-ycc3csyh	997	55	from	from	IN
cord-270892-ycc3csyh	997	56	higher	high	JJR
cord-270892-ycc3csyh	997	57	plants	plant	NNS
cord-270892-ycc3csyh	997	58	and	and	CC
cord-270892-ycc3csyh	997	59	example	example	NN
cord-270892-ycc3csyh	997	60	of	of	IN
cord-270892-ycc3csyh	997	61	structure	structure	NN
cord-270892-ycc3csyh	997	62	-	-	HYPH
cord-270892-ycc3csyh	997	63	activity	activity	NN
cord-270892-ycc3csyh	997	64	relationship	relationship	NN
cord-270892-ycc3csyh	997	65	of	of	IN
cord-270892-ycc3csyh	997	66	3-methoxyflavones	3-methoxyflavones	CD
cord-270892-ycc3csyh	997	67	0	0	CD
cord-270892-ycc3csyh	997	68	-Hydroxy-3-methoxyflavones	-Hydroxy-3-methoxyflavones	:
cord-270892-ycc3csyh	997	69	with	with	IN
cord-270892-ycc3csyh	997	70	potent	potent	JJ
cord-270892-ycc3csyh	997	71	antipicornavirus	antipicornavirus	JJ
cord-270892-ycc3csyh	997	72	activity	activity	NN
cord-270892-ycc3csyh	997	73	Biodiversity	biodiversity	NN
cord-270892-ycc3csyh	997	74	:	:	:
cord-270892-ycc3csyh	997	75	A	a	DT
cord-270892-ycc3csyh	997	76	continuing	continue	VBG
cord-270892-ycc3csyh	997	77	source	source	NN
cord-270892-ycc3csyh	997	78	of	of	IN
cord-270892-ycc3csyh	997	79	novel	novel	JJ
cord-270892-ycc3csyh	997	80	drug	drug	NN
cord-270892-ycc3csyh	997	81	leads	lead	VBZ
cord-270892-ycc3csyh	997	82	Structure	Structure	NNP
cord-270892-ycc3csyh	997	83	and	and	CC
cord-270892-ycc3csyh	997	84	stereochemistry	stereochemistry	NN
cord-270892-ycc3csyh	997	85	of	of	IN
cord-270892-ycc3csyh	997	86	thysanone	thysanone	NNP
cord-270892-ycc3csyh	997	87	:	:	:
cord-270892-ycc3csyh	998	1	A	a	DT
cord-270892-ycc3csyh	998	2	novel	novel	JJ
cord-270892-ycc3csyh	998	3	human	human	JJ
cord-270892-ycc3csyh	998	4	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	998	5	3C	3c	NN
cord-270892-ycc3csyh	998	6	-	-	HYPH
cord-270892-ycc3csyh	998	7	protease	protease	NN
cord-270892-ycc3csyh	998	8	inhibitor	inhibitor	NN
cord-270892-ycc3csyh	998	9	from	from	IN
cord-270892-ycc3csyh	998	10	Thysanophora	Thysanophora	NNP
cord-270892-ycc3csyh	998	11	penicilloides	penicilloide	VBZ
cord-270892-ycc3csyh	998	12	Discovery	Discovery	NNP
cord-270892-ycc3csyh	998	13	,	,	,
cord-270892-ycc3csyh	998	14	total	total	JJ
cord-270892-ycc3csyh	998	15	synthesis	synthesis	NN
cord-270892-ycc3csyh	998	16	,	,	,
cord-270892-ycc3csyh	998	17	HRV	HRV	NNP
cord-270892-ycc3csyh	998	18	3C	3c	NN
cord-270892-ycc3csyh	998	19	-	-	HYPH
cord-270892-ycc3csyh	998	20	protease	protease	NN
cord-270892-ycc3csyh	998	21	inhibitory	inhibitory	JJ
cord-270892-ycc3csyh	998	22	activity	activity	NN
cord-270892-ycc3csyh	998	23	,	,	,
cord-270892-ycc3csyh	998	24	and	and	CC
cord-270892-ycc3csyh	998	25	structure	structure	NN
cord-270892-ycc3csyh	998	26	-	-	HYPH
cord-270892-ycc3csyh	998	27	activity	activity	NN
cord-270892-ycc3csyh	998	28	relationships	relationship	NNS
cord-270892-ycc3csyh	998	29	of	of	IN
cord-270892-ycc3csyh	998	30	2-methoxystypandrone	2-methoxystypandrone	CD
cord-270892-ycc3csyh	998	31	and	and	CC
cord-270892-ycc3csyh	998	32	its	-PRON-	PRP$
cord-270892-ycc3csyh	998	33	analogues	analogue	NNS
cord-270892-ycc3csyh	998	34	Antiviral	Antiviral	NNP
cord-270892-ycc3csyh	998	35	activity	activity	NN
cord-270892-ycc3csyh	998	36	of	of	IN
cord-270892-ycc3csyh	998	37	raoulic	raoulic	JJ
cord-270892-ycc3csyh	998	38	acid	acid	NN
cord-270892-ycc3csyh	998	39	from	from	IN
cord-270892-ycc3csyh	998	40	Raoulia	Raoulia	NNP
cord-270892-ycc3csyh	998	41	australis	australis	NN
cord-270892-ycc3csyh	998	42	against	against	IN
cord-270892-ycc3csyh	998	43	Picornaviruses	Picornaviruses	NNP
cord-270892-ycc3csyh	998	44	Antipicornavirus	Antipicornavirus	NNP
cord-270892-ycc3csyh	998	45	flavone	flavone	NN
cord-270892-ycc3csyh	998	46	Ro	Ro	NNP
cord-270892-ycc3csyh	998	47	09	09	CD
cord-270892-ycc3csyh	998	48	-	-	HYPH
cord-270892-ycc3csyh	998	49	0179	0179	CD
cord-270892-ycc3csyh	999	1	Cinnamoyl	Cinnamoyl	NNP
cord-270892-ycc3csyh	999	2	-	-	HYPH
cord-270892-ycc3csyh	999	3	and	and	CC
cord-270892-ycc3csyh	999	4	hydroxycinnamoyl	hydroxycinnamoyl	NNP
cord-270892-ycc3csyh	999	5	amides	amide	NNS
cord-270892-ycc3csyh	999	6	of	of	IN
cord-270892-ycc3csyh	999	7	glaucine	glaucine	NN
cord-270892-ycc3csyh	999	8	and	and	CC
cord-270892-ycc3csyh	999	9	their	-PRON-	PRP$
cord-270892-ycc3csyh	999	10	antioxidative	antioxidative	JJ
cord-270892-ycc3csyh	999	11	and	and	CC
cord-270892-ycc3csyh	999	12	antiviral	antiviral	JJ
cord-270892-ycc3csyh	999	13	activities	activity	NNS
cord-270892-ycc3csyh	999	14	Antiviral	antiviral	JJ
cord-270892-ycc3csyh	999	15	activity	activity	NN
cord-270892-ycc3csyh	999	16	of	of	IN
cord-270892-ycc3csyh	999	17	flavones	flavone	NNS
cord-270892-ycc3csyh	999	18	and	and	CC
cord-270892-ycc3csyh	999	19	flavans	flavans	NNP
cord-270892-ycc3csyh	999	20	Present	present	JJ
cord-270892-ycc3csyh	999	21	status	status	NN
cord-270892-ycc3csyh	999	22	and	and	CC
cord-270892-ycc3csyh	999	23	prospects	prospect	NNS
cord-270892-ycc3csyh	999	24	of	of	IN
cord-270892-ycc3csyh	999	25	flavonoids	flavonoid	NNS
cord-270892-ycc3csyh	999	26	as	as	IN
cord-270892-ycc3csyh	999	27	antiviral	antiviral	JJ
cord-270892-ycc3csyh	999	28	agents	agent	NNS
cord-270892-ycc3csyh	999	29	Inhibition	Inhibition	NNP
cord-270892-ycc3csyh	999	30	of	of	IN
cord-270892-ycc3csyh	999	31	an	an	DT
cord-270892-ycc3csyh	999	32	early	early	JJ
cord-270892-ycc3csyh	999	33	stage	stage	NN
cord-270892-ycc3csyh	999	34	of	of	IN
cord-270892-ycc3csyh	999	35	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	999	36	replication	replication	NN
cord-270892-ycc3csyh	999	37	by	by	IN
cord-270892-ycc3csyh	999	38	dichloroflavan	dichloroflavan	NNP
cord-270892-ycc3csyh	999	39	(	(	-LRB-
cord-270892-ycc3csyh	999	40	BW683C	BW683C	NNP
cord-270892-ycc3csyh	999	41	)	)	-RRB-
cord-270892-ycc3csyh	999	42	Effect	Effect	NNP
cord-270892-ycc3csyh	999	43	of	of	IN
cord-270892-ycc3csyh	999	44	dichloroflavan	dichloroflavan	NNP
cord-270892-ycc3csyh	999	45	(	(	-LRB-
cord-270892-ycc3csyh	999	46	BW683C	BW683C	NNP
cord-270892-ycc3csyh	999	47	)	)	-RRB-
cord-270892-ycc3csyh	999	48	on	on	IN
cord-270892-ycc3csyh	999	49	the	the	DT
cord-270892-ycc3csyh	999	50	stability	stability	NN
cord-270892-ycc3csyh	999	51	and	and	CC
cord-270892-ycc3csyh	999	52	uncoating	uncoating	NN
cord-270892-ycc3csyh	999	53	of	of	IN
cord-270892-ycc3csyh	1000	1	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	1000	2	type	type	NN
cord-270892-ycc3csyh	1000	3	1B	1b	NN
cord-270892-ycc3csyh	1000	4	Failure	failure	NN
cord-270892-ycc3csyh	1000	5	of	of	IN
cord-270892-ycc3csyh	1000	6	intranasally	intranasally	RB
cord-270892-ycc3csyh	1000	7	administered	administer	VBN
cord-270892-ycc3csyh	1000	8	4	4	CD
cord-270892-ycc3csyh	1000	9	0	0	CD
cord-270892-ycc3csyh	1000	10	,	,	,
cord-270892-ycc3csyh	1000	11	6-dichloroflavan	6-dichloroflavan	CD
cord-270892-ycc3csyh	1000	12	to	to	TO
cord-270892-ycc3csyh	1000	13	protect	protect	VB
cord-270892-ycc3csyh	1000	14	against	against	IN
cord-270892-ycc3csyh	1000	15	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	1000	16	infection	infection	NN
cord-270892-ycc3csyh	1000	17	in	in	IN
cord-270892-ycc3csyh	1000	18	man	man	NN
cord-270892-ycc3csyh	1000	19	Failure	failure	NN
cord-270892-ycc3csyh	1000	20	of	of	IN
cord-270892-ycc3csyh	1000	21	oral	oral	JJ
cord-270892-ycc3csyh	1000	22	4	4	CD
cord-270892-ycc3csyh	1000	23	0	0	CD
cord-270892-ycc3csyh	1000	24	,	,	,
cord-270892-ycc3csyh	1000	25	6-dichloroflavan	6-dichloroflavan	CD
cord-270892-ycc3csyh	1000	26	to	to	TO
cord-270892-ycc3csyh	1000	27	protect	protect	VB
cord-270892-ycc3csyh	1000	28	against	against	IN
cord-270892-ycc3csyh	1000	29	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	1000	30	infection	infection	NN
cord-270892-ycc3csyh	1000	31	in	in	IN
cord-270892-ycc3csyh	1000	32	man	man	NN
cord-270892-ycc3csyh	1000	33	Neural	neural	JJ
cord-270892-ycc3csyh	1000	34	networks	network	NNS
cord-270892-ycc3csyh	1000	35	as	as	IN
cord-270892-ycc3csyh	1000	36	data	datum	NNS
cord-270892-ycc3csyh	1000	37	mining	mining	NN
cord-270892-ycc3csyh	1000	38	tools	tool	NNS
cord-270892-ycc3csyh	1000	39	in	in	IN
cord-270892-ycc3csyh	1000	40	drug	drug	NN
cord-270892-ycc3csyh	1000	41	design	design	NN
cord-270892-ycc3csyh	1000	42	Chemoinformatics	chemoinformatic	NNS
cord-270892-ycc3csyh	1000	43	and	and	CC
cord-270892-ycc3csyh	1000	44	drug	drug	NN
cord-270892-ycc3csyh	1000	45	discovery	discovery	NN
cord-270892-ycc3csyh	1000	46	Methods	method	NNS
cord-270892-ycc3csyh	1000	47	and	and	CC
cord-270892-ycc3csyh	1000	48	principles	principle	NNS
cord-270892-ycc3csyh	1000	49	in	in	IN
cord-270892-ycc3csyh	1000	50	medicinal	medicinal	JJ
cord-270892-ycc3csyh	1000	51	chemistry	chemistry	NN
cord-270892-ycc3csyh	1001	1	The	the	DT
cord-270892-ycc3csyh	1001	2	impact	impact	NN
cord-270892-ycc3csyh	1001	3	of	of	IN
cord-270892-ycc3csyh	1001	4	informatics	informatic	NNS
cord-270892-ycc3csyh	1001	5	and	and	CC
cord-270892-ycc3csyh	1001	6	computational	computational	JJ
cord-270892-ycc3csyh	1001	7	chemistry	chemistry	NN
cord-270892-ycc3csyh	1001	8	on	on	IN
cord-270892-ycc3csyh	1001	9	synthesis	synthesis	NN
cord-270892-ycc3csyh	1001	10	and	and	CC
cord-270892-ycc3csyh	1001	11	screening	screen	VBG
cord-270892-ycc3csyh	1001	12	Enhancing	enhance	VBG
cord-270892-ycc3csyh	1001	13	drug	drug	NN
cord-270892-ycc3csyh	1001	14	discovery	discovery	NN
cord-270892-ycc3csyh	1001	15	through	through	IN
cord-270892-ycc3csyh	1001	16	in	in	IN
cord-270892-ycc3csyh	1001	17	silico	silico	NN
cord-270892-ycc3csyh	1001	18	screening	screening	NN
cord-270892-ycc3csyh	1001	19	:	:	:
cord-270892-ycc3csyh	1001	20	Strategies	strategy	NNS
cord-270892-ycc3csyh	1001	21	to	to	TO
cord-270892-ycc3csyh	1001	22	increase	increase	VB
cord-270892-ycc3csyh	1001	23	true	true	JJ
cord-270892-ycc3csyh	1001	24	positives	positive	NNS
cord-270892-ycc3csyh	1001	25	retrieval	retrieval	NN
cord-270892-ycc3csyh	1001	26	rates	rate	NNS
cord-270892-ycc3csyh	1002	1	Neural	neural	JJ
cord-270892-ycc3csyh	1002	2	networks	network	NNS
cord-270892-ycc3csyh	1002	3	for	for	IN
cord-270892-ycc3csyh	1002	4	chemists	chemist	NNS
cord-270892-ycc3csyh	1003	1	The	the	DT
cord-270892-ycc3csyh	1003	2	Protein	Protein	NNP
cord-270892-ycc3csyh	1003	3	Data	Data	NNP
cord-270892-ycc3csyh	1003	4	Bank	Bank	NNP
cord-270892-ycc3csyh	1004	1	The	the	DT
cord-270892-ycc3csyh	1004	2	Protein	Protein	NNP
cord-270892-ycc3csyh	1004	3	Data	Data	NNP
cord-270892-ycc3csyh	1004	4	Bank	Bank	NNP
cord-270892-ycc3csyh	1004	5	(	(	-LRB-
cord-270892-ycc3csyh	1004	6	PDB	PDB	NNP
cord-270892-ycc3csyh	1004	7	)	)	-RRB-
cord-270892-ycc3csyh	1004	8	,	,	,
cord-270892-ycc3csyh	1004	9	its	-PRON-	PRP$
cord-270892-ycc3csyh	1004	10	related	related	JJ
cord-270892-ycc3csyh	1004	11	services	service	NNS
cord-270892-ycc3csyh	1004	12	and	and	CC
cord-270892-ycc3csyh	1004	13	software	software	NN
cord-270892-ycc3csyh	1004	14	tools	tool	NNS
cord-270892-ycc3csyh	1004	15	as	as	IN
cord-270892-ycc3csyh	1004	16	key	key	JJ
cord-270892-ycc3csyh	1004	17	components	component	NNS
cord-270892-ycc3csyh	1004	18	for	for	IN
cord-270892-ycc3csyh	1004	19	in	in	IN
cord-270892-ycc3csyh	1004	20	silico	silico	NN
cord-270892-ycc3csyh	1004	21	guided	guide	VBN
cord-270892-ycc3csyh	1004	22	drug	drug	NN
cord-270892-ycc3csyh	1004	23	discovery	discovery	NN
cord-270892-ycc3csyh	1004	24	Development	Development	NNP
cord-270892-ycc3csyh	1004	25	of	of	IN
cord-270892-ycc3csyh	1004	26	antiviral	antiviral	JJ
cord-270892-ycc3csyh	1004	27	agents	agent	NNS
cord-270892-ycc3csyh	1004	28	using	use	VBG
cord-270892-ycc3csyh	1004	29	molecular	molecular	JJ
cord-270892-ycc3csyh	1004	30	modeling	modeling	NN
cord-270892-ycc3csyh	1004	31	and	and	CC
cord-270892-ycc3csyh	1004	32	virtual	virtual	JJ
cord-270892-ycc3csyh	1004	33	screening	screening	NN
cord-270892-ycc3csyh	1004	34	techniques	technique	NNS
cord-270892-ycc3csyh	1004	35	Comparative	comparative	JJ
cord-270892-ycc3csyh	1004	36	molecular	molecular	JJ
cord-270892-ycc3csyh	1004	37	field	field	NN
cord-270892-ycc3csyh	1004	38	analysis	analysis	NN
cord-270892-ycc3csyh	1004	39	(	(	-LRB-
cord-270892-ycc3csyh	1004	40	CoMFA	CoMFA	NNP
cord-270892-ycc3csyh	1004	41	)	)	-RRB-
cord-270892-ycc3csyh	1004	42	.	.	.
cord-270892-ycc3csyh	1005	1	1	1	LS
cord-270892-ycc3csyh	1005	2	.	.	.
cord-270892-ycc3csyh	1006	1	Effect	effect	NN
cord-270892-ycc3csyh	1006	2	of	of	IN
cord-270892-ycc3csyh	1006	3	shape	shape	NN
cord-270892-ycc3csyh	1006	4	on	on	IN
cord-270892-ycc3csyh	1006	5	binding	binding	NN
cord-270892-ycc3csyh	1006	6	of	of	IN
cord-270892-ycc3csyh	1006	7	steroids	steroid	NNS
cord-270892-ycc3csyh	1006	8	to	to	IN
cord-270892-ycc3csyh	1006	9	carrier	carrier	NN
cord-270892-ycc3csyh	1006	10	proteins	protein	NNS
cord-270892-ycc3csyh	1006	11	Investigation	Investigation	NNP
cord-270892-ycc3csyh	1006	12	on	on	IN
cord-270892-ycc3csyh	1006	13	QSAR	QSAR	NNP
cord-270892-ycc3csyh	1006	14	and	and	CC
cord-270892-ycc3csyh	1006	15	binding	binding	NN
cord-270892-ycc3csyh	1006	16	mode	mode	NN
cord-270892-ycc3csyh	1006	17	of	of	IN
cord-270892-ycc3csyh	1006	18	a	a	DT
cord-270892-ycc3csyh	1006	19	new	new	JJ
cord-270892-ycc3csyh	1006	20	class	class	NN
cord-270892-ycc3csyh	1006	21	of	of	IN
cord-270892-ycc3csyh	1006	22	human	human	JJ
cord-270892-ycc3csyh	1006	23	rhinovirus-14	rhinovirus-14	NNP
cord-270892-ycc3csyh	1006	24	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	1006	25	by	by	IN
cord-270892-ycc3csyh	1006	26	CoMFA	CoMFA	NNP
cord-270892-ycc3csyh	1006	27	and	and	CC
cord-270892-ycc3csyh	1006	28	docking	docking	NN
cord-270892-ycc3csyh	1006	29	experiments	experiment	NNS
cord-270892-ycc3csyh	1006	30	Synthesis	synthesis	NN
cord-270892-ycc3csyh	1006	31	and	and	CC
cord-270892-ycc3csyh	1006	32	structure	structure	NN
cord-270892-ycc3csyh	1006	33	-	-	HYPH
cord-270892-ycc3csyh	1006	34	activity	activity	NN
cord-270892-ycc3csyh	1006	35	studies	study	NNS
cord-270892-ycc3csyh	1006	36	of	of	IN
cord-270892-ycc3csyh	1006	37	some	some	DT
cord-270892-ycc3csyh	1006	38	disubstituted	disubstitute	VBN
cord-270892-ycc3csyh	1006	39	phenylisoxazoles	phenylisoxazole	NNS
cord-270892-ycc3csyh	1006	40	against	against	IN
cord-270892-ycc3csyh	1006	41	human	human	JJ
cord-270892-ycc3csyh	1006	42	picornavirus	picornavirus	NNP
cord-270892-ycc3csyh	1006	43	CoMFA	CoMFA	NNP
cord-270892-ycc3csyh	1006	44	analysis	analysis	NN
cord-270892-ycc3csyh	1006	45	of	of	IN
cord-270892-ycc3csyh	1006	46	the	the	DT
cord-270892-ycc3csyh	1006	47	interactions	interaction	NNS
cord-270892-ycc3csyh	1006	48	of	of	IN
cord-270892-ycc3csyh	1006	49	antipicornavirus	antipicornavirus	NNP
cord-270892-ycc3csyh	1006	50	compounds	compound	NNS
cord-270892-ycc3csyh	1006	51	in	in	IN
cord-270892-ycc3csyh	1006	52	the	the	DT
cord-270892-ycc3csyh	1006	53	binding	bind	VBG
cord-270892-ycc3csyh	1006	54	pocket	pocket	NN
cord-270892-ycc3csyh	1006	55	of	of	IN
cord-270892-ycc3csyh	1006	56	human	human	JJ
cord-270892-ycc3csyh	1006	57	rhinovirus-14	rhinovirus-14	NNP
cord-270892-ycc3csyh	1006	58	dihydro-2-oxazolyl)phenoxy]alkyl]-3-methylisoxazoles	dihydro-2-oxazolyl)phenoxy]alkyl]-3-methylisoxazole	NNS
cord-270892-ycc3csyh	1006	59	:	:	:
cord-270892-ycc3csyh	1007	1	Inhibitors	Inhibitors	NNP
cord-270892-ycc3csyh	1007	2	of	of	IN
cord-270892-ycc3csyh	1007	3	picornavirus	picornavirus	NNP
cord-270892-ycc3csyh	1007	4	uncoating	uncoate	VBG
cord-270892-ycc3csyh	1007	5	Understanding	understand	VBG
cord-270892-ycc3csyh	1007	6	human	human	JJ
cord-270892-ycc3csyh	1007	7	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	1007	8	infections	infection	NNS
cord-270892-ycc3csyh	1007	9	in	in	IN
cord-270892-ycc3csyh	1007	10	terms	term	NNS
cord-270892-ycc3csyh	1007	11	of	of	IN
cord-270892-ycc3csyh	1007	12	QSAR	QSAR	NNP
cord-270892-ycc3csyh	1007	13	Site	site	NN
cord-270892-ycc3csyh	1007	14	-	-	HYPH
cord-270892-ycc3csyh	1007	15	directed	direct	VBN
cord-270892-ycc3csyh	1007	16	mutagenesis	mutagenesis	NN
cord-270892-ycc3csyh	1007	17	suggests	suggest	VBZ
cord-270892-ycc3csyh	1007	18	close	close	JJ
cord-270892-ycc3csyh	1007	19	functional	functional	JJ
cord-270892-ycc3csyh	1007	20	relationship	relationship	NN
cord-270892-ycc3csyh	1007	21	between	between	IN
cord-270892-ycc3csyh	1007	22	a	a	DT
cord-270892-ycc3csyh	1007	23	human	human	JJ
cord-270892-ycc3csyh	1007	24	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	1007	25	3C	3C	NNP
cord-270892-ycc3csyh	1007	26	cysteine	cysteine	NN
cord-270892-ycc3csyh	1007	27	protease	protease	NN
cord-270892-ycc3csyh	1007	28	and	and	CC
cord-270892-ycc3csyh	1007	29	cellular	cellular	JJ
cord-270892-ycc3csyh	1007	30	trypsin	trypsin	NN
cord-270892-ycc3csyh	1007	31	-	-	HYPH
cord-270892-ycc3csyh	1007	32	like	like	JJ
cord-270892-ycc3csyh	1007	33	serine	serine	NN
cord-270892-ycc3csyh	1007	34	proteases	protease	NNS
cord-270892-ycc3csyh	1007	35	The	the	DT
cord-270892-ycc3csyh	1007	36	picornaviral	picornaviral	NNP
cord-270892-ycc3csyh	1007	37	3C	3C	NNP
cord-270892-ycc3csyh	1007	38	proteinases	proteinases	NNP
cord-270892-ycc3csyh	1007	39	:	:	:
cord-270892-ycc3csyh	1008	1	Cysteine	cysteine	NN
cord-270892-ycc3csyh	1008	2	nucleophiles	nucleophile	NNS
cord-270892-ycc3csyh	1008	3	in	in	IN
cord-270892-ycc3csyh	1008	4	serine	serine	NN
cord-270892-ycc3csyh	1008	5	proteinase	proteinase	NN
cord-270892-ycc3csyh	1008	6	folds	fold	NNS
cord-270892-ycc3csyh	1008	7	Substituted	substitute	VBN
cord-270892-ycc3csyh	1008	8	benzamide	benzamide	NN
cord-270892-ycc3csyh	1008	9	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	1008	10	of	of	IN
cord-270892-ycc3csyh	1009	1	human	human	JJ
cord-270892-ycc3csyh	1009	2	rhinovirus	rhinovirus	NNP
cord-270892-ycc3csyh	1009	3	3C	3C	NNP
cord-270892-ycc3csyh	1009	4	protease	protease	NN
cord-270892-ycc3csyh	1009	5	:	:	:
cord-270892-ycc3csyh	1009	6	Structure	structure	NN
cord-270892-ycc3csyh	1009	7	-	-	HYPH
cord-270892-ycc3csyh	1009	8	based	base	VBN
cord-270892-ycc3csyh	1009	9	design	design	NN
cord-270892-ycc3csyh	1009	10	,	,	,
cord-270892-ycc3csyh	1009	11	synthesis	synthesis	NN
cord-270892-ycc3csyh	1009	12	,	,	,
cord-270892-ycc3csyh	1009	13	and	and	CC
cord-270892-ycc3csyh	1009	14	biological	biological	JJ
cord-270892-ycc3csyh	1009	15	evaluation	evaluation	NN
cord-270892-ycc3csyh	1009	16	Structure	structure	NN
cord-270892-ycc3csyh	1009	17	-	-	HYPH
cord-270892-ycc3csyh	1009	18	based	base	VBN
cord-270892-ycc3csyh	1009	19	design	design	NN
cord-270892-ycc3csyh	1009	20	,	,	,
cord-270892-ycc3csyh	1009	21	synthesis	synthesis	NN
cord-270892-ycc3csyh	1009	22	,	,	,
cord-270892-ycc3csyh	1009	23	and	and	CC
cord-270892-ycc3csyh	1009	24	biological	biological	JJ
cord-270892-ycc3csyh	1009	25	evaluation	evaluation	NN
cord-270892-ycc3csyh	1009	26	of	of	IN
cord-270892-ycc3csyh	1009	27	irreversible	irreversible	JJ
cord-270892-ycc3csyh	1009	28	human	human	JJ
cord-270892-ycc3csyh	1009	29	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	1009	30	3C	3C	NNP
cord-270892-ycc3csyh	1009	31	protease	protease	NN
cord-270892-ycc3csyh	1009	32	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	1009	33	.	.	.
cord-270892-ycc3csyh	1010	1	6	6	LS
cord-270892-ycc3csyh	1010	2	.	.	.
cord-270892-ycc3csyh	1011	1	Structure	structure	NN
cord-270892-ycc3csyh	1011	2	-	-	HYPH
cord-270892-ycc3csyh	1011	3	activity	activity	NN
cord-270892-ycc3csyh	1011	4	studies	study	NNS
cord-270892-ycc3csyh	1011	5	of	of	IN
cord-270892-ycc3csyh	1011	6	orally	orally	RB
cord-270892-ycc3csyh	1011	7	bioavailable	bioavailable	JJ
cord-270892-ycc3csyh	1011	8	,	,	,
cord-270892-ycc3csyh	1011	9	2-pyridone	2-pyridone	CD
cord-270892-ycc3csyh	1011	10	-	-	HYPH
cord-270892-ycc3csyh	1011	11	containing	contain	VBG
cord-270892-ycc3csyh	1011	12	peptidomimetics	peptidomimetic	NNS
cord-270892-ycc3csyh	1011	13	Glossary	Glossary	NNP
cord-270892-ycc3csyh	1011	14	of	of	IN
cord-270892-ycc3csyh	1011	15	terms	term	NNS
cord-270892-ycc3csyh	1011	16	used	use	VBN
cord-270892-ycc3csyh	1011	17	in	in	IN
cord-270892-ycc3csyh	1011	18	medicinal	medicinal	JJ
cord-270892-ycc3csyh	1011	19	chemistry	chemistry	NN
cord-270892-ycc3csyh	1011	20	(	(	-LRB-
cord-270892-ycc3csyh	1011	21	IUPAC	IUPAC	NNP
cord-270892-ycc3csyh	1011	22	recommendations	recommendation	NNS
cord-270892-ycc3csyh	1011	23	1997	1997	CD
cord-270892-ycc3csyh	1011	24	)	)	-RRB-
cord-270892-ycc3csyh	1012	1	Methods	method	NNS
cord-270892-ycc3csyh	1012	2	and	and	CC
cord-270892-ycc3csyh	1012	3	principles	principle	NNS
cord-270892-ycc3csyh	1012	4	in	in	IN
cord-270892-ycc3csyh	1012	5	medicinal	medicinal	JJ
cord-270892-ycc3csyh	1012	6	chemistry	chemistry	NN
cord-270892-ycc3csyh	1012	7	Human	Human	NNP
cord-270892-ycc3csyh	1012	8	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	1012	9	3C	3c	NN
cord-270892-ycc3csyh	1012	10	protease	protease	NN
cord-270892-ycc3csyh	1012	11	:	:	:
cord-270892-ycc3csyh	1012	12	Generation	generation	NN
cord-270892-ycc3csyh	1012	13	of	of	IN
cord-270892-ycc3csyh	1012	14	pharmacophore	pharmacophore	NN
cord-270892-ycc3csyh	1012	15	models	model	NNS
cord-270892-ycc3csyh	1012	16	for	for	IN
cord-270892-ycc3csyh	1012	17	peptidic	peptidic	NNP
cord-270892-ycc3csyh	1012	18	and	and	CC
cord-270892-ycc3csyh	1012	19	nonpeptidic	nonpeptidic	NNP
cord-270892-ycc3csyh	1012	20	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	1012	21	and	and	CC
cord-270892-ycc3csyh	1012	22	their	-PRON-	PRP$
cord-270892-ycc3csyh	1012	23	application	application	NN
cord-270892-ycc3csyh	1012	24	in	in	IN
cord-270892-ycc3csyh	1012	25	virtual	virtual	JJ
cord-270892-ycc3csyh	1012	26	screening	screening	NN
cord-270892-ycc3csyh	1012	27	Docking	docking	NN
cord-270892-ycc3csyh	1012	28	versus	versus	IN
cord-270892-ycc3csyh	1012	29	pharmacophore	pharmacophore	JJ
cord-270892-ycc3csyh	1012	30	model	model	NN
cord-270892-ycc3csyh	1012	31	generation	generation	NN
cord-270892-ycc3csyh	1012	32	:	:	:
cord-270892-ycc3csyh	1012	33	A	a	DT
cord-270892-ycc3csyh	1012	34	comparison	comparison	NN
cord-270892-ycc3csyh	1012	35	of	of	IN
cord-270892-ycc3csyh	1012	36	highthroughput	highthroughput	NN
cord-270892-ycc3csyh	1012	37	virtual	virtual	JJ
cord-270892-ycc3csyh	1012	38	screening	screening	NN
cord-270892-ycc3csyh	1012	39	strategies	strategy	NNS
cord-270892-ycc3csyh	1012	40	for	for	IN
cord-270892-ycc3csyh	1012	41	the	the	DT
cord-270892-ycc3csyh	1012	42	search	search	NN
cord-270892-ycc3csyh	1012	43	of	of	IN
cord-270892-ycc3csyh	1012	44	human	human	JJ
cord-270892-ycc3csyh	1012	45	rhinovirus	rhinovirus	NN
cord-270892-ycc3csyh	1012	46	coat	coat	NN
cord-270892-ycc3csyh	1012	47	protein	protein	NN
cord-270892-ycc3csyh	1012	48	inhibitors	inhibitor	NNS
cord-270892-ycc3csyh	1013	1	CA	CA	NNP
cord-270892-ycc3csyh	1013	2	:	:	:
cord-270892-ycc3csyh	1013	3	Accelrys	Accelrys	NNP
cord-270892-ycc3csyh	1013	4	.	.	.
cord-270892-ycc3csyh	1014	1	358	358	CD
cord-270892-ycc3csyh	1014	2	.	.	.
cord-270892-ycc3csyh	1015	1	Discovery	Discovery	NNP
cord-270892-ycc3csyh	1015	2	Studio	Studio	NNP
cord-270892-ycc3csyh	1015	3	Rollinger	Rollinger	NNP
cord-270892-ycc3csyh	1015	4	extended	extend	VBD
cord-270892-ycc3csyh	1015	5	her	-PRON-	PRP$
cord-270892-ycc3csyh	1015	6	studies	study	NNS
cord-270892-ycc3csyh	1015	7	to	to	IN
cord-270892-ycc3csyh	1015	8	the	the	DT
cord-270892-ycc3csyh	1015	9	fields	field	NNS
cord-270892-ycc3csyh	1015	10	of	of	IN
cord-270892-ycc3csyh	1015	11	phytochemistry	phytochemistry	NN
cord-270892-ycc3csyh	1015	12	,	,	,
cord-270892-ycc3csyh	1015	13	ethnopharmacology	ethnopharmacology	NN
cord-270892-ycc3csyh	1015	14	,	,	,
cord-270892-ycc3csyh	1015	15	molecular	molecular	JJ
cord-270892-ycc3csyh	1015	16	modelling	modelling	NN
cord-270892-ycc3csyh	1015	17	and	and	CC
cord-270892-ycc3csyh	1015	18	its	-PRON-	PRP$
cord-270892-ycc3csyh	1015	19	application	application	NN
cord-270892-ycc3csyh	1015	20	in	in	IN
cord-270892-ycc3csyh	1015	21	natural	natural	JJ
cord-270892-ycc3csyh	1015	22	product	product	NN
cord-270892-ycc3csyh	1015	23	science	science	NN
cord-270892-ycc3csyh	1015	24	completing	complete	VBG
cord-270892-ycc3csyh	1015	25	the	the	DT
cord-270892-ycc3csyh	1015	26	habilitation	habilitation	NN
cord-270892-ycc3csyh	1015	27	thesis	thesis	NN
cord-270892-ycc3csyh	1015	28	entitled	entitle	VBN
cord-270892-ycc3csyh	1015	29	''	''	''
cord-270892-ycc3csyh	1016	1	The	the	DT
cord-270892-ycc3csyh	1016	2	search	search	NN
cord-270892-ycc3csyh	1016	3	for	for	IN
cord-270892-ycc3csyh	1016	4	bioactive	bioactive	JJ
cord-270892-ycc3csyh	1016	5	natural	natural	JJ
cord-270892-ycc3csyh	1016	6	products	product	NNS
cord-270892-ycc3csyh	1017	1	Rollinger	Rollinger	NNP
cord-270892-ycc3csyh	1017	2	is	be	VBZ
cord-270892-ycc3csyh	1017	3	a	a	DT
cord-270892-ycc3csyh	1017	4	project	project	NN
cord-270892-ycc3csyh	1017	5	leader	leader	NN
cord-270892-ycc3csyh	1017	6	and	and	CC
cord-270892-ycc3csyh	1017	7	an	an	DT
cord-270892-ycc3csyh	1017	8	associate	associate	NN
cord-270892-ycc3csyh	1017	9	in	in	IN
cord-270892-ycc3csyh	1017	10	various	various	JJ
cord-270892-ycc3csyh	1017	11	national	national	JJ
cord-270892-ycc3csyh	1017	12	projects	project	NNS
cord-270892-ycc3csyh	1017	13	,	,	,
cord-270892-ycc3csyh	1017	14	as	as	RB
cord-270892-ycc3csyh	1017	15	well	well	RB
cord-270892-ycc3csyh	1017	16	as	as	IN
cord-270892-ycc3csyh	1017	17	executive	executive	JJ
cord-270892-ycc3csyh	1017	18	guest	guest	NN
cord-270892-ycc3csyh	1017	19	editor	editor	NN
cord-270892-ycc3csyh	1017	20	for	for	IN
cord-270892-ycc3csyh	1017	21	Current	Current	NNP
cord-270892-ycc3csyh	1017	22	Pharmaceutical	Pharmaceutical	NNP
cord-270892-ycc3csyh	1017	23	Design	Design	NNP
cord-270892-ycc3csyh	1017	24	.	.	.
cord-270892-ycc3csyh	1018	1	She	-PRON-	PRP
cord-270892-ycc3csyh	1018	2	has	have	VBZ
cord-270892-ycc3csyh	1018	3	been	be	VBN
cord-270892-ycc3csyh	1018	4	awarded	award	VBN
cord-270892-ycc3csyh	1018	5	the	the	DT
cord-270892-ycc3csyh	1018	6	PHOENIX	PHOENIX	NNP
cord-270892-ycc3csyh	1018	7	Science	Science	NNP
cord-270892-ycc3csyh	1018	8	award	award	NN
cord-270892-ycc3csyh	1018	9	(	(	-LRB-
cord-270892-ycc3csyh	1018	10	2005	2005	CD
cord-270892-ycc3csyh	1018	11	)	)	-RRB-
cord-270892-ycc3csyh	1018	12	and	and	CC
cord-270892-ycc3csyh	1018	13	received	receive	VBD
cord-270892-ycc3csyh	1018	14	several	several	JJ
cord-270892-ycc3csyh	1018	15	additional	additional	JJ
cord-270892-ycc3csyh	1018	16	awards	award	NNS
cord-270892-ycc3csyh	1018	17	Until	until	IN
cord-270892-ycc3csyh	1018	18	1994	1994	CD
cord-270892-ycc3csyh	1019	1	she	-PRON-	PRP
cord-270892-ycc3csyh	1019	2	was	be	VBD
cord-270892-ycc3csyh	1019	3	a	a	DT
cord-270892-ycc3csyh	1019	4	postdoctoral	postdoctoral	JJ
cord-270892-ycc3csyh	1019	5	research	research	NN
cord-270892-ycc3csyh	1019	6	fellow	fellow	NN
cord-270892-ycc3csyh	1019	7	at	at	IN
cord-270892-ycc3csyh	1019	8	the	the	DT
cord-270892-ycc3csyh	1019	9	Institute	Institute	NNP
cord-270892-ycc3csyh	1019	10	of	of	IN
cord-270892-ycc3csyh	1019	11	Immunology	Immunology	NNP
cord-270892-ycc3csyh	1019	12	,	,	,
cord-270892-ycc3csyh	1019	13	University	University	NNP
cord-270892-ycc3csyh	1019	14	Marburg	Marburg	NNP
cord-270892-ycc3csyh	1019	15	,	,	,
cord-270892-ycc3csyh	1019	16	where	where	WRB
cord-270892-ycc3csyh	1019	17	she	-PRON-	PRP
cord-270892-ycc3csyh	1019	18	studied	study	VBD
cord-270892-ycc3csyh	1019	19	picornavirusimmune	picornavirusimmune	NN
cord-270892-ycc3csyh	1019	20	cell	cell	NN
cord-270892-ycc3csyh	1019	21	interactions	interaction	NNS
cord-270892-ycc3csyh	1019	22	and	and	CC
cord-270892-ycc3csyh	1019	23	the	the	DT
cord-270892-ycc3csyh	1019	24	virus	virus	NN
cord-270892-ycc3csyh	1019	25	-	-	HYPH
cord-270892-ycc3csyh	1019	26	induced	induce	VBN
cord-270892-ycc3csyh	1019	27	cytokine	cytokine	NN
cord-270892-ycc3csyh	1019	28	induction	induction	NN
cord-270892-ycc3csyh	1019	29	.	.	.
cord-270892-ycc3csyh	1020	1	Thereafter	thereafter	RB
cord-270892-ycc3csyh	1020	2	,	,	,
cord-270892-ycc3csyh	1020	3	she	-PRON-	PRP
cord-270892-ycc3csyh	1020	4	was	be	VBD
cord-270892-ycc3csyh	1020	5	a	a	DT
cord-270892-ycc3csyh	1020	6	postdoctoral	postdoctoral	JJ
cord-270892-ycc3csyh	1020	7	fellow	fellow	NN
cord-270892-ycc3csyh	1020	8	at	at	IN
cord-270892-ycc3csyh	1020	9	the	the	DT
cord-270892-ycc3csyh	1020	10	Institute	Institute	NNP
cord-270892-ycc3csyh	1020	11	of	of	IN
cord-270892-ycc3csyh	1020	12	Virology	Virology	NNP
cord-270892-ycc3csyh	1020	13	and	and	CC
cord-270892-ycc3csyh	1020	14	Antiviral	Antiviral	NNP
cord-270892-ycc3csyh	1020	15	Therapy	Therapy	NNP