id sid tid token lemma pos cord-254580-nhpjvgt4 1 1 key key JJ cord-254580-nhpjvgt4 1 2 : : : cord-254580-nhpjvgt4 1 3 cord-254580-nhpjvgt4 cord-254580-nhpjvgt4 NN cord-254580-nhpjvgt4 1 4 authors author NNS cord-254580-nhpjvgt4 1 5 : : : cord-254580-nhpjvgt4 1 6 Ricardo Ricardo NNP cord-254580-nhpjvgt4 1 7 , , , cord-254580-nhpjvgt4 1 8 Jose Jose NNP cord-254580-nhpjvgt4 1 9 W. W. NNP cord-254580-nhpjvgt4 1 10 ; ; : cord-254580-nhpjvgt4 1 11 Lipner Lipner NNP cord-254580-nhpjvgt4 1 12 , , , cord-254580-nhpjvgt4 1 13 Shari Shari NNP cord-254580-nhpjvgt4 1 14 R. R. NNP cord-254580-nhpjvgt4 1 15 title title NN cord-254580-nhpjvgt4 1 16 : : : cord-254580-nhpjvgt4 1 17 Considerations consideration NNS cord-254580-nhpjvgt4 1 18 for for IN cord-254580-nhpjvgt4 1 19 Safety safety NN cord-254580-nhpjvgt4 1 20 in in IN cord-254580-nhpjvgt4 1 21 the the DT cord-254580-nhpjvgt4 1 22 Use Use NNP cord-254580-nhpjvgt4 1 23 of of IN cord-254580-nhpjvgt4 1 24 Systemic systemic JJ cord-254580-nhpjvgt4 1 25 Medications medication NNS cord-254580-nhpjvgt4 1 26 for for IN cord-254580-nhpjvgt4 1 27 Psoriasis Psoriasis NNP cord-254580-nhpjvgt4 1 28 and and CC cord-254580-nhpjvgt4 1 29 Atopic Atopic NNP cord-254580-nhpjvgt4 1 30 Dermatitis Dermatitis NNP cord-254580-nhpjvgt4 1 31 during during IN cord-254580-nhpjvgt4 1 32 the the DT cord-254580-nhpjvgt4 1 33 COVID‐19 COVID‐19 NNP cord-254580-nhpjvgt4 1 34 pandemic pandemic NN cord-254580-nhpjvgt4 1 35 date date NN cord-254580-nhpjvgt4 1 36 : : : cord-254580-nhpjvgt4 1 37 2020 2020 CD cord-254580-nhpjvgt4 1 38 - - HYPH cord-254580-nhpjvgt4 1 39 05 05 CD cord-254580-nhpjvgt4 1 40 - - HYPH cord-254580-nhpjvgt4 1 41 27 27 CD cord-254580-nhpjvgt4 1 42 journal journal NN cord-254580-nhpjvgt4 1 43 : : : cord-254580-nhpjvgt4 2 1 Dermatol Dermatol NNP cord-254580-nhpjvgt4 3 1 Ther ther JJ cord-254580-nhpjvgt4 3 2 DOI DOI NNP cord-254580-nhpjvgt4 3 3 : : : cord-254580-nhpjvgt4 4 1 10.1111 10.1111 CD cord-254580-nhpjvgt4 4 2 / / SYM cord-254580-nhpjvgt4 4 3 dth.13687 dth.13687 NN cord-254580-nhpjvgt4 4 4 sha sha NNP cord-254580-nhpjvgt4 4 5 : : : cord-254580-nhpjvgt4 5 1 da516a5f665fcb8a6f3a1fd350bcfa34820d951a da516a5f665fcb8a6f3a1fd350bcfa34820d951a NNP cord-254580-nhpjvgt4 5 2 doc_id doc_id CD cord-254580-nhpjvgt4 5 3 : : : cord-254580-nhpjvgt4 5 4 254580 254580 CD cord-254580-nhpjvgt4 6 1 cord_uid cord_uid NN cord-254580-nhpjvgt4 6 2 : : : cord-254580-nhpjvgt4 7 1 nhpjvgt4 nhpjvgt4 NN cord-254580-nhpjvgt4 7 2 Coronavirus Coronavirus NNP cord-254580-nhpjvgt4 7 3 disease disease NN cord-254580-nhpjvgt4 7 4 2019 2019 CD cord-254580-nhpjvgt4 8 1 ( ( -LRB- cord-254580-nhpjvgt4 8 2 COVID‐19 COVID‐19 NNP cord-254580-nhpjvgt4 8 3 ) ) -RRB- cord-254580-nhpjvgt4 8 4 , , , cord-254580-nhpjvgt4 8 5 is be VBZ cord-254580-nhpjvgt4 8 6 responsible responsible JJ cord-254580-nhpjvgt4 8 7 for for IN cord-254580-nhpjvgt4 8 8 at at RB cord-254580-nhpjvgt4 8 9 least least JJS cord-254580-nhpjvgt4 8 10 2,546,527 2,546,527 CD cord-254580-nhpjvgt4 8 11 cases case NNS cord-254580-nhpjvgt4 8 12 and and CC cord-254580-nhpjvgt4 8 13 175,812 175,812 CD cord-254580-nhpjvgt4 8 14 deaths death NNS cord-254580-nhpjvgt4 8 15 as as IN cord-254580-nhpjvgt4 8 16 of of IN cord-254580-nhpjvgt4 8 17 April April NNP cord-254580-nhpjvgt4 8 18 21 21 CD cord-254580-nhpjvgt4 8 19 , , , cord-254580-nhpjvgt4 8 20 2020 2020 CD cord-254580-nhpjvgt4 8 21 . . . cord-254580-nhpjvgt4 9 1 Psoriasis psoriasis NN cord-254580-nhpjvgt4 9 2 and and CC cord-254580-nhpjvgt4 9 3 atopic atopic JJ cord-254580-nhpjvgt4 9 4 dermatitis dermatitis NN cord-254580-nhpjvgt4 9 5 are be VBP cord-254580-nhpjvgt4 9 6 common common JJ cord-254580-nhpjvgt4 9 7 , , , cord-254580-nhpjvgt4 9 8 chronic chronic JJ cord-254580-nhpjvgt4 9 9 , , , cord-254580-nhpjvgt4 9 10 inflammatory inflammatory JJ cord-254580-nhpjvgt4 9 11 skin skin NN cord-254580-nhpjvgt4 9 12 conditions condition NNS cord-254580-nhpjvgt4 9 13 , , , cord-254580-nhpjvgt4 9 14 with with IN cord-254580-nhpjvgt4 9 15 immune immune JJ cord-254580-nhpjvgt4 9 16 dysregulation dysregulation NN cord-254580-nhpjvgt4 9 17 as as IN cord-254580-nhpjvgt4 9 18 a a DT cord-254580-nhpjvgt4 9 19 shared share VBN cord-254580-nhpjvgt4 9 20 mechanism mechanism NN cord-254580-nhpjvgt4 9 21 ; ; : cord-254580-nhpjvgt4 9 22 therefore therefore RB cord-254580-nhpjvgt4 9 23 , , , cord-254580-nhpjvgt4 9 24 mainstays mainstay NNS cord-254580-nhpjvgt4 9 25 of of IN cord-254580-nhpjvgt4 9 26 treatment treatment NN cord-254580-nhpjvgt4 9 27 include include VBP cord-254580-nhpjvgt4 9 28 systemic systemic JJ cord-254580-nhpjvgt4 9 29 immunomodulating immunomodulating JJ cord-254580-nhpjvgt4 9 30 therapies therapy NNS cord-254580-nhpjvgt4 9 31 . . . cord-254580-nhpjvgt4 10 1 It -PRON- PRP cord-254580-nhpjvgt4 10 2 is be VBZ cord-254580-nhpjvgt4 10 3 unknown unknown JJ cord-254580-nhpjvgt4 10 4 whether whether IN cord-254580-nhpjvgt4 10 5 these these DT cord-254580-nhpjvgt4 10 6 therapies therapy NNS cord-254580-nhpjvgt4 10 7 are be VBP cord-254580-nhpjvgt4 10 8 associated associate VBN cord-254580-nhpjvgt4 10 9 with with IN cord-254580-nhpjvgt4 10 10 increased increase VBN cord-254580-nhpjvgt4 10 11 to to IN cord-254580-nhpjvgt4 10 12 COVID‐19 covid‐19 NN cord-254580-nhpjvgt4 10 13 susceptibility susceptibility NN cord-254580-nhpjvgt4 10 14 or or CC cord-254580-nhpjvgt4 10 15 worse bad JJR cord-254580-nhpjvgt4 10 16 outcomes outcome NNS cord-254580-nhpjvgt4 10 17 in in IN cord-254580-nhpjvgt4 10 18 infected infected JJ cord-254580-nhpjvgt4 10 19 patients patient NNS cord-254580-nhpjvgt4 10 20 . . . cord-254580-nhpjvgt4 11 1 In in IN cord-254580-nhpjvgt4 11 2 this this DT cord-254580-nhpjvgt4 11 3 review review NN cord-254580-nhpjvgt4 11 4 , , , cord-254580-nhpjvgt4 11 5 we -PRON- PRP cord-254580-nhpjvgt4 11 6 discuss discuss VBP cord-254580-nhpjvgt4 11 7 overall overall JJ cord-254580-nhpjvgt4 11 8 infection infection NN cord-254580-nhpjvgt4 11 9 risks risk NNS cord-254580-nhpjvgt4 11 10 of of IN cord-254580-nhpjvgt4 11 11 non‐biologic non‐biologic JJ cord-254580-nhpjvgt4 11 12 and and CC cord-254580-nhpjvgt4 11 13 biologic biologic JJ cord-254580-nhpjvgt4 11 14 systemic systemic JJ cord-254580-nhpjvgt4 11 15 medications medication NNS cord-254580-nhpjvgt4 11 16 for for IN cord-254580-nhpjvgt4 11 17 psoriasis psoriasis NN cord-254580-nhpjvgt4 11 18 and and CC cord-254580-nhpjvgt4 11 19 atopic atopic JJ cord-254580-nhpjvgt4 11 20 dermatitis dermatitis NN cord-254580-nhpjvgt4 11 21 , , , cord-254580-nhpjvgt4 11 22 and and CC cord-254580-nhpjvgt4 11 23 provide provide VB cord-254580-nhpjvgt4 11 24 therapeutic therapeutic JJ cord-254580-nhpjvgt4 11 25 recommendations recommendation NNS cord-254580-nhpjvgt4 11 26 . . . cord-254580-nhpjvgt4 12 1 In in IN cord-254580-nhpjvgt4 12 2 summary summary NN cord-254580-nhpjvgt4 12 3 , , , cord-254580-nhpjvgt4 12 4 in in IN cord-254580-nhpjvgt4 12 5 patients patient NNS cord-254580-nhpjvgt4 12 6 with with IN cord-254580-nhpjvgt4 12 7 active active JJ cord-254580-nhpjvgt4 12 8 infection infection NN cord-254580-nhpjvgt4 12 9 , , , cord-254580-nhpjvgt4 12 10 systemic systemic JJ cord-254580-nhpjvgt4 12 11 conventional conventional JJ cord-254580-nhpjvgt4 12 12 medications medication NNS cord-254580-nhpjvgt4 12 13 , , , cord-254580-nhpjvgt4 12 14 the the DT cord-254580-nhpjvgt4 12 15 JAK JAK NNP cord-254580-nhpjvgt4 12 16 inhibitor inhibitor NN cord-254580-nhpjvgt4 12 17 tofacitinib tofacitinib NNP cord-254580-nhpjvgt4 12 18 , , , cord-254580-nhpjvgt4 12 19 and and CC cord-254580-nhpjvgt4 12 20 biologics biologic NNS cord-254580-nhpjvgt4 12 21 for for IN cord-254580-nhpjvgt4 12 22 psoriasis psoriasis NN cord-254580-nhpjvgt4 12 23 should should MD cord-254580-nhpjvgt4 12 24 be be VB cord-254580-nhpjvgt4 12 25 temporarily temporarily RB cord-254580-nhpjvgt4 12 26 held hold VBN cord-254580-nhpjvgt4 12 27 until until IN cord-254580-nhpjvgt4 12 28 there there EX cord-254580-nhpjvgt4 12 29 is be VBZ cord-254580-nhpjvgt4 12 30 more more JJR cord-254580-nhpjvgt4 12 31 data datum NNS cord-254580-nhpjvgt4 12 32 ; ; : cord-254580-nhpjvgt4 12 33 in in IN cord-254580-nhpjvgt4 12 34 uninfected uninfected JJ cord-254580-nhpjvgt4 12 35 patients patient NNS cord-254580-nhpjvgt4 12 36 switching switch VBG cord-254580-nhpjvgt4 12 37 to to IN cord-254580-nhpjvgt4 12 38 safer safe JJR cord-254580-nhpjvgt4 12 39 alternatives alternative NNS cord-254580-nhpjvgt4 12 40 should should MD cord-254580-nhpjvgt4 12 41 be be VB cord-254580-nhpjvgt4 12 42 considered consider VBN cord-254580-nhpjvgt4 12 43 . . . cord-254580-nhpjvgt4 13 1 Interleukin Interleukin NNP cord-254580-nhpjvgt4 13 2 ( ( -LRB- cord-254580-nhpjvgt4 13 3 IL)‐17 IL)‐17 NNP cord-254580-nhpjvgt4 13 4 , , , cord-254580-nhpjvgt4 13 5 IL‐12/23 il‐12/23 JJ cord-254580-nhpjvgt4 13 6 and and CC cord-254580-nhpjvgt4 13 7 IL‐23 il‐23 CD cord-254580-nhpjvgt4 14 1 inhibitors inhibitor NNS cord-254580-nhpjvgt4 14 2 are be VBP cord-254580-nhpjvgt4 14 3 associated associate VBN cord-254580-nhpjvgt4 14 4 with with IN cord-254580-nhpjvgt4 14 5 low low JJ cord-254580-nhpjvgt4 14 6 infection infection NN cord-254580-nhpjvgt4 14 7 risk risk NN cord-254580-nhpjvgt4 14 8 , , , cord-254580-nhpjvgt4 14 9 with with IN cord-254580-nhpjvgt4 14 10 IL‐17 IL‐17 NNP cord-254580-nhpjvgt4 14 11 and and CC cord-254580-nhpjvgt4 14 12 IL‐23 IL‐23 NNP cord-254580-nhpjvgt4 14 13 favored favor VBD cord-254580-nhpjvgt4 14 14 over over IN cord-254580-nhpjvgt4 14 15 IL‐12/23 il‐12/23 JJ cord-254580-nhpjvgt4 14 16 inhibitors inhibitor NNS cord-254580-nhpjvgt4 14 17 . . . cord-254580-nhpjvgt4 15 1 Pivotal pivotal JJ cord-254580-nhpjvgt4 15 2 trials trial NNS cord-254580-nhpjvgt4 15 3 and and CC cord-254580-nhpjvgt4 15 4 postmarketing postmarkete VBG cord-254580-nhpjvgt4 15 5 data datum NNS cord-254580-nhpjvgt4 15 6 also also RB cord-254580-nhpjvgt4 15 7 suggest suggest VBP cord-254580-nhpjvgt4 15 8 that that IN cord-254580-nhpjvgt4 15 9 IL‐17 IL‐17 NNP cord-254580-nhpjvgt4 15 10 and and CC cord-254580-nhpjvgt4 15 11 IL‐23 il‐23 NN cord-254580-nhpjvgt4 15 12 blockers blocker NNS cord-254580-nhpjvgt4 15 13 are be VBP cord-254580-nhpjvgt4 15 14 safer safe JJR cord-254580-nhpjvgt4 15 15 than than IN cord-254580-nhpjvgt4 15 16 TNF‐blockers tnf‐blocker NNS cord-254580-nhpjvgt4 15 17 . . . cord-254580-nhpjvgt4 16 1 Apremilast Apremilast NNP cord-254580-nhpjvgt4 16 2 , , , cord-254580-nhpjvgt4 16 3 acitretin acitretin NNP cord-254580-nhpjvgt4 16 4 and and CC cord-254580-nhpjvgt4 16 5 dupilumab dupilumab NNP cord-254580-nhpjvgt4 16 6 , , , cord-254580-nhpjvgt4 16 7 have have VBP cord-254580-nhpjvgt4 16 8 favorable favorable JJ cord-254580-nhpjvgt4 16 9 safety safety NN cord-254580-nhpjvgt4 16 10 data datum NNS cord-254580-nhpjvgt4 16 11 , , , cord-254580-nhpjvgt4 16 12 and and CC cord-254580-nhpjvgt4 16 13 may may MD cord-254580-nhpjvgt4 16 14 be be VB cord-254580-nhpjvgt4 16 15 safely safely RB cord-254580-nhpjvgt4 16 16 initiated initiate VBN cord-254580-nhpjvgt4 16 17 and and CC cord-254580-nhpjvgt4 16 18 continued continue VBN cord-254580-nhpjvgt4 16 19 in in IN cord-254580-nhpjvgt4 16 20 uninfected uninfected JJ cord-254580-nhpjvgt4 16 21 patients patient NNS cord-254580-nhpjvgt4 16 22 . . . cord-254580-nhpjvgt4 17 1 Without without IN cord-254580-nhpjvgt4 17 2 definitive definitive JJ cord-254580-nhpjvgt4 17 3 COVID‐19 COVID‐19 NNP cord-254580-nhpjvgt4 17 4 data datum NNS cord-254580-nhpjvgt4 17 5 , , , cord-254580-nhpjvgt4 17 6 these these DT cord-254580-nhpjvgt4 17 7 recommendations recommendation NNS cord-254580-nhpjvgt4 17 8 may may MD cord-254580-nhpjvgt4 17 9 be be VB cord-254580-nhpjvgt4 17 10 useful useful JJ cord-254580-nhpjvgt4 17 11 in in IN cord-254580-nhpjvgt4 17 12 guiding guide VBG cord-254580-nhpjvgt4 17 13 treatment treatment NN cord-254580-nhpjvgt4 17 14 of of IN cord-254580-nhpjvgt4 17 15 psoriasis psoriasis NN cord-254580-nhpjvgt4 17 16 and and CC cord-254580-nhpjvgt4 17 17 atopic atopic JJ cord-254580-nhpjvgt4 17 18 dermatitis dermatitis NN cord-254580-nhpjvgt4 17 19 patients patient NNS cord-254580-nhpjvgt4 17 20 during during IN cord-254580-nhpjvgt4 17 21 the the DT cord-254580-nhpjvgt4 17 22 COVID‐19 COVID‐19 NNP cord-254580-nhpjvgt4 17 23 pandemic pandemic NN cord-254580-nhpjvgt4 17 24 . . . cord-254580-nhpjvgt4 18 1 This this DT cord-254580-nhpjvgt4 18 2 article article NN cord-254580-nhpjvgt4 18 3 is be VBZ cord-254580-nhpjvgt4 18 4 protected protect VBN cord-254580-nhpjvgt4 18 5 by by IN cord-254580-nhpjvgt4 18 6 copyright copyright NN cord-254580-nhpjvgt4 18 7 . . . cord-254580-nhpjvgt4 19 1 All all DT cord-254580-nhpjvgt4 19 2 rights right NNS cord-254580-nhpjvgt4 19 3 reserved reserve VBN cord-254580-nhpjvgt4 19 4 . . . cord-254580-nhpjvgt4 20 1 Severe severe JJ cord-254580-nhpjvgt4 20 2 acute acute JJ cord-254580-nhpjvgt4 20 3 respiratory respiratory JJ cord-254580-nhpjvgt4 20 4 syndrome syndrome NN cord-254580-nhpjvgt4 20 5 coronavirus coronavirus NN cord-254580-nhpjvgt4 20 6 2 2 CD cord-254580-nhpjvgt4 21 1 ( ( -LRB- cord-254580-nhpjvgt4 21 2 SARS SARS NNP cord-254580-nhpjvgt4 21 3 - - HYPH cord-254580-nhpjvgt4 21 4 CoV-2 CoV-2 NNP cord-254580-nhpjvgt4 21 5 ) ) -RRB- cord-254580-nhpjvgt4 21 6 is be VBZ cord-254580-nhpjvgt4 21 7 a a DT cord-254580-nhpjvgt4 21 8 novel novel JJ cord-254580-nhpjvgt4 21 9 human human JJ cord-254580-nhpjvgt4 21 10 coronavirus coronavirus NN cord-254580-nhpjvgt4 21 11 , , , cord-254580-nhpjvgt4 21 12 with with IN cord-254580-nhpjvgt4 21 13 2,546,527 2,546,527 CD cord-254580-nhpjvgt4 21 14 confirmed confirm VBN cord-254580-nhpjvgt4 21 15 cases case NNS cord-254580-nhpjvgt4 21 16 of of IN cord-254580-nhpjvgt4 21 17 coronavirus coronavirus NN cord-254580-nhpjvgt4 21 18 disease disease NN cord-254580-nhpjvgt4 21 19 2019 2019 CD cord-254580-nhpjvgt4 21 20 ( ( -LRB- cord-254580-nhpjvgt4 21 21 COVID-19 COVID-19 NNP cord-254580-nhpjvgt4 21 22 ) ) -RRB- cord-254580-nhpjvgt4 21 23 and and CC cord-254580-nhpjvgt4 21 24 175,812 175,812 CD cord-254580-nhpjvgt4 21 25 deaths death NNS cord-254580-nhpjvgt4 21 26 worldwide worldwide RB cord-254580-nhpjvgt4 21 27 ( ( -LRB- cord-254580-nhpjvgt4 21 28 April April NNP cord-254580-nhpjvgt4 21 29 21 21 CD cord-254580-nhpjvgt4 21 30 , , , cord-254580-nhpjvgt4 21 31 2020 2020 CD cord-254580-nhpjvgt4 21 32 ) ) -RRB- cord-254580-nhpjvgt4 21 33 . . . cord-254580-nhpjvgt4 22 1 1 1 LS cord-254580-nhpjvgt4 23 1 It -PRON- PRP cord-254580-nhpjvgt4 23 2 was be VBD cord-254580-nhpjvgt4 23 3 declared declare VBN cord-254580-nhpjvgt4 23 4 a a DT cord-254580-nhpjvgt4 23 5 pandemic pandemic NN cord-254580-nhpjvgt4 23 6 by by IN cord-254580-nhpjvgt4 23 7 the the DT cord-254580-nhpjvgt4 23 8 World World NNP cord-254580-nhpjvgt4 23 9 Health Health NNP cord-254580-nhpjvgt4 23 10 Organization Organization NNP cord-254580-nhpjvgt4 23 11 . . . cord-254580-nhpjvgt4 24 1 An an DT cord-254580-nhpjvgt4 24 2 overall overall JJ cord-254580-nhpjvgt4 24 3 case case NN cord-254580-nhpjvgt4 24 4 fatality fatality NN cord-254580-nhpjvgt4 24 5 rate rate NN cord-254580-nhpjvgt4 24 6 of of IN cord-254580-nhpjvgt4 24 7 3.61 3.61 CD cord-254580-nhpjvgt4 24 8 % % NN cord-254580-nhpjvgt4 24 9 has have VBZ cord-254580-nhpjvgt4 24 10 been be VBN cord-254580-nhpjvgt4 24 11 reported report VBN cord-254580-nhpjvgt4 24 12 , , , cord-254580-nhpjvgt4 24 13 2 2 CD cord-254580-nhpjvgt4 24 14 however however RB cord-254580-nhpjvgt4 24 15 , , , cord-254580-nhpjvgt4 24 16 inaccuracies inaccuracy NNS cord-254580-nhpjvgt4 24 17 may may MD cord-254580-nhpjvgt4 24 18 exist exist VB cord-254580-nhpjvgt4 24 19 because because IN cord-254580-nhpjvgt4 24 20 those those DT cord-254580-nhpjvgt4 24 21 who who WP cord-254580-nhpjvgt4 24 22 are be VBP cord-254580-nhpjvgt4 24 23 asymptomatic asymptomatic JJ cord-254580-nhpjvgt4 24 24 or or CC cord-254580-nhpjvgt4 24 25 suffer suffer VBP cord-254580-nhpjvgt4 24 26 from from IN cord-254580-nhpjvgt4 24 27 mild mild JJ cord-254580-nhpjvgt4 24 28 disease disease NN cord-254580-nhpjvgt4 24 29 may may MD cord-254580-nhpjvgt4 24 30 never never RB cord-254580-nhpjvgt4 24 31 receive receive VB cord-254580-nhpjvgt4 24 32 confirmation confirmation NN cord-254580-nhpjvgt4 24 33 . . . cord-254580-nhpjvgt4 25 1 Psoriasis psoriasis NN cord-254580-nhpjvgt4 25 2 and and CC cord-254580-nhpjvgt4 25 3 atopic atopic JJ cord-254580-nhpjvgt4 25 4 dermatitis dermatitis NN cord-254580-nhpjvgt4 25 5 ( ( -LRB- cord-254580-nhpjvgt4 25 6 AD ad NN cord-254580-nhpjvgt4 25 7 ) ) -RRB- cord-254580-nhpjvgt4 25 8 are be VBP cord-254580-nhpjvgt4 25 9 common common JJ cord-254580-nhpjvgt4 25 10 , , , cord-254580-nhpjvgt4 25 11 chronic chronic JJ cord-254580-nhpjvgt4 25 12 , , , cord-254580-nhpjvgt4 25 13 inflammatory inflammatory JJ cord-254580-nhpjvgt4 25 14 skin skin NN cord-254580-nhpjvgt4 25 15 diseases disease NNS cord-254580-nhpjvgt4 25 16 , , , cord-254580-nhpjvgt4 25 17 affecting affect VBG cord-254580-nhpjvgt4 25 18 2 2 CD cord-254580-nhpjvgt4 25 19 - - SYM cord-254580-nhpjvgt4 25 20 3 3 CD cord-254580-nhpjvgt4 25 21 % % NN cord-254580-nhpjvgt4 25 22 of of IN cord-254580-nhpjvgt4 25 23 the the DT cord-254580-nhpjvgt4 25 24 general general JJ cord-254580-nhpjvgt4 25 25 population population NN cord-254580-nhpjvgt4 25 26 and and CC cord-254580-nhpjvgt4 25 27 7 7 CD cord-254580-nhpjvgt4 25 28 % % NN cord-254580-nhpjvgt4 25 29 of of IN cord-254580-nhpjvgt4 25 30 adults adult NNS cord-254580-nhpjvgt4 25 31 in in IN cord-254580-nhpjvgt4 25 32 the the DT cord-254580-nhpjvgt4 25 33 United United NNP cord-254580-nhpjvgt4 25 34 States States NNP cord-254580-nhpjvgt4 25 35 ( ( -LRB- cord-254580-nhpjvgt4 25 36 US US NNP cord-254580-nhpjvgt4 25 37 ) ) -RRB- cord-254580-nhpjvgt4 25 38 , , , cord-254580-nhpjvgt4 25 39 respectively respectively RB cord-254580-nhpjvgt4 25 40 . . . cord-254580-nhpjvgt4 26 1 3 3 LS cord-254580-nhpjvgt4 26 2 , , , cord-254580-nhpjvgt4 26 3 4 4 CD cord-254580-nhpjvgt4 26 4 Disease Disease NNP cord-254580-nhpjvgt4 26 5 mechanisms mechanism NNS cord-254580-nhpjvgt4 26 6 are be VBP cord-254580-nhpjvgt4 26 7 multifactorial multifactorial JJ cord-254580-nhpjvgt4 26 8 , , , cord-254580-nhpjvgt4 26 9 with with IN cord-254580-nhpjvgt4 26 10 immune immune JJ cord-254580-nhpjvgt4 26 11 dysregulation dysregulation NN cord-254580-nhpjvgt4 26 12 important important JJ cord-254580-nhpjvgt4 26 13 for for IN cord-254580-nhpjvgt4 26 14 both both DT cord-254580-nhpjvgt4 26 15 conditions condition NNS cord-254580-nhpjvgt4 26 16 , , , cord-254580-nhpjvgt4 26 17 and and CC cord-254580-nhpjvgt4 26 18 mainstays mainstay NNS cord-254580-nhpjvgt4 26 19 of of IN cord-254580-nhpjvgt4 26 20 treatment treatment NN cord-254580-nhpjvgt4 26 21 immune immune JJ cord-254580-nhpjvgt4 26 22 - - HYPH cord-254580-nhpjvgt4 26 23 modulation modulation NN cord-254580-nhpjvgt4 26 24 . . . cord-254580-nhpjvgt4 27 1 5 5 CD cord-254580-nhpjvgt4 27 2 Systemic systemic JJ cord-254580-nhpjvgt4 27 3 therapy therapy NN cord-254580-nhpjvgt4 27 4 is be VBZ cord-254580-nhpjvgt4 27 5 preferred prefer VBN cord-254580-nhpjvgt4 27 6 for for IN cord-254580-nhpjvgt4 27 7 psoriasis psoriasis NN cord-254580-nhpjvgt4 27 8 treatment treatment NN cord-254580-nhpjvgt4 27 9 in in IN cord-254580-nhpjvgt4 27 10 patients patient NNS cord-254580-nhpjvgt4 27 11 with with IN cord-254580-nhpjvgt4 27 12 Body Body NNP cord-254580-nhpjvgt4 27 13 Surface Surface NNP cord-254580-nhpjvgt4 27 14 Area>10 Area>10 NNP cord-254580-nhpjvgt4 27 15 % % NN cord-254580-nhpjvgt4 27 16 , , , cord-254580-nhpjvgt4 27 17 involvement involvement NN cord-254580-nhpjvgt4 27 18 of of IN cord-254580-nhpjvgt4 27 19 sensitive sensitive JJ cord-254580-nhpjvgt4 27 20 areas area NNS cord-254580-nhpjvgt4 27 21 or or CC cord-254580-nhpjvgt4 27 22 topical topical JJ cord-254580-nhpjvgt4 27 23 therapy therapy NN cord-254580-nhpjvgt4 27 24 failure failure NN cord-254580-nhpjvgt4 27 25 . . . cord-254580-nhpjvgt4 28 1 6 6 CD cord-254580-nhpjvgt4 28 2 Systemic systemic JJ cord-254580-nhpjvgt4 28 3 treatment treatment NN cord-254580-nhpjvgt4 28 4 is be VBZ cord-254580-nhpjvgt4 28 5 recommended recommend VBN cord-254580-nhpjvgt4 28 6 for for IN cord-254580-nhpjvgt4 28 7 AD ad NN cord-254580-nhpjvgt4 28 8 patients patient NNS cord-254580-nhpjvgt4 28 9 with with IN cord-254580-nhpjvgt4 28 10 severe severe JJ cord-254580-nhpjvgt4 28 11 disease disease NN cord-254580-nhpjvgt4 28 12 or or CC cord-254580-nhpjvgt4 28 13 recalcitrant recalcitrant JJ cord-254580-nhpjvgt4 28 14 to to IN cord-254580-nhpjvgt4 28 15 topical topical JJ cord-254580-nhpjvgt4 28 16 therapy therapy NN cord-254580-nhpjvgt4 28 17 . . . cord-254580-nhpjvgt4 29 1 7 7 CD cord-254580-nhpjvgt4 30 1 Immunocompromised immunocompromise VBN cord-254580-nhpjvgt4 30 2 patients patient NNS cord-254580-nhpjvgt4 30 3 are be VBP cord-254580-nhpjvgt4 30 4 highly highly RB cord-254580-nhpjvgt4 30 5 vulnerable vulnerable JJ cord-254580-nhpjvgt4 30 6 to to IN cord-254580-nhpjvgt4 30 7 infections infection NNS cord-254580-nhpjvgt4 30 8 , , , cord-254580-nhpjvgt4 30 9 which which WDT cord-254580-nhpjvgt4 30 10 is be VBZ cord-254580-nhpjvgt4 30 11 particularly particularly RB cord-254580-nhpjvgt4 30 12 concerning concern VBG cord-254580-nhpjvgt4 30 13 in in IN cord-254580-nhpjvgt4 30 14 the the DT cord-254580-nhpjvgt4 30 15 context context NN cord-254580-nhpjvgt4 30 16 of of IN cord-254580-nhpjvgt4 30 17 the the DT cord-254580-nhpjvgt4 30 18 COVID-19 COVID-19 NNP cord-254580-nhpjvgt4 30 19 pandemic pandemic NN cord-254580-nhpjvgt4 30 20 . . . cord-254580-nhpjvgt4 31 1 In in IN cord-254580-nhpjvgt4 31 2 this this DT cord-254580-nhpjvgt4 31 3 review review NN cord-254580-nhpjvgt4 31 4 , , , cord-254580-nhpjvgt4 31 5 we -PRON- PRP cord-254580-nhpjvgt4 31 6 summarize summarize VBP cord-254580-nhpjvgt4 31 7 the the DT cord-254580-nhpjvgt4 31 8 current current JJ cord-254580-nhpjvgt4 31 9 literature literature NN cord-254580-nhpjvgt4 31 10 regarding regard VBG cord-254580-nhpjvgt4 31 11 overall overall JJ cord-254580-nhpjvgt4 31 12 infection infection NN cord-254580-nhpjvgt4 31 13 risks risk NNS cord-254580-nhpjvgt4 31 14 with with IN cord-254580-nhpjvgt4 31 15 systemic systemic JJ cord-254580-nhpjvgt4 31 16 immunomodulating immunomodulating JJ cord-254580-nhpjvgt4 31 17 agents agent NNS cord-254580-nhpjvgt4 31 18 for for IN cord-254580-nhpjvgt4 31 19 psoriasis psoriasis NN cord-254580-nhpjvgt4 31 20 and and CC cord-254580-nhpjvgt4 31 21 AD ad NN cord-254580-nhpjvgt4 31 22 , , , cord-254580-nhpjvgt4 31 23 and and CC cord-254580-nhpjvgt4 31 24 provide provide VB cord-254580-nhpjvgt4 31 25 evidence evidence NN cord-254580-nhpjvgt4 31 26 - - HYPH cord-254580-nhpjvgt4 31 27 based base VBN cord-254580-nhpjvgt4 31 28 treatment treatment NN cord-254580-nhpjvgt4 31 29 recommendations recommendation NNS cord-254580-nhpjvgt4 31 30 during during IN cord-254580-nhpjvgt4 31 31 the the DT cord-254580-nhpjvgt4 31 32 COVID-19 COVID-19 NNP cord-254580-nhpjvgt4 31 33 pandemic pandemic NN cord-254580-nhpjvgt4 31 34 . . . cord-254580-nhpjvgt4 32 1 Systemic systemic JJ cord-254580-nhpjvgt4 32 2 corticosteroids corticosteroid NNS cord-254580-nhpjvgt4 32 3 are be VBP cord-254580-nhpjvgt4 32 4 immunosuppressive immunosuppressive JJ cord-254580-nhpjvgt4 32 5 medications medication NNS cord-254580-nhpjvgt4 32 6 used use VBN cord-254580-nhpjvgt4 32 7 to to TO cord-254580-nhpjvgt4 32 8 treat treat VB cord-254580-nhpjvgt4 32 9 AD ad NN cord-254580-nhpjvgt4 32 10 flares flare NNS cord-254580-nhpjvgt4 32 11 , , , cord-254580-nhpjvgt4 32 12 but but CC cord-254580-nhpjvgt4 32 13 very very RB cord-254580-nhpjvgt4 32 14 rarely rarely RB cord-254580-nhpjvgt4 32 15 psoriasis psoriasis NN cord-254580-nhpjvgt4 32 16 . . . cord-254580-nhpjvgt4 33 1 They -PRON- PRP cord-254580-nhpjvgt4 33 2 have have VBP cord-254580-nhpjvgt4 33 3 been be VBN cord-254580-nhpjvgt4 33 4 shown show VBN cord-254580-nhpjvgt4 33 5 to to TO cord-254580-nhpjvgt4 33 6 increase increase VB cord-254580-nhpjvgt4 33 7 infection infection NN cord-254580-nhpjvgt4 33 8 risk risk NN cord-254580-nhpjvgt4 33 9 . . . cord-254580-nhpjvgt4 34 1 In in IN cord-254580-nhpjvgt4 34 2 a a DT cord-254580-nhpjvgt4 34 3 systematic systematic JJ cord-254580-nhpjvgt4 34 4 review review NN cord-254580-nhpjvgt4 34 5 of of IN cord-254580-nhpjvgt4 34 6 101 101 CD cord-254580-nhpjvgt4 34 7 studies study NNS cord-254580-nhpjvgt4 34 8 on on IN cord-254580-nhpjvgt4 34 9 AD ad NN cord-254580-nhpjvgt4 34 10 children child NNS cord-254580-nhpjvgt4 34 11 ( ( -LRB- cord-254580-nhpjvgt4 34 12 n=6,817 n=6,817 NNP cord-254580-nhpjvgt4 34 13 ) ) -RRB- cord-254580-nhpjvgt4 34 14 treated treat VBN cord-254580-nhpjvgt4 34 15 with with IN cord-254580-nhpjvgt4 34 16 systemic systemic JJ cord-254580-nhpjvgt4 34 17 corticosteroids corticosteroid NNS cord-254580-nhpjvgt4 34 18 ≥15 ≥15 NNP cord-254580-nhpjvgt4 34 19 days day NNS cord-254580-nhpjvgt4 34 20 , , , cord-254580-nhpjvgt4 34 21 infection infection NN cord-254580-nhpjvgt4 34 22 rate rate NN cord-254580-nhpjvgt4 34 23 was be VBD cord-254580-nhpjvgt4 34 24 8.7 8.7 CD cord-254580-nhpjvgt4 34 25 % % NN cord-254580-nhpjvgt4 34 26 , , , cord-254580-nhpjvgt4 34 27 with with IN cord-254580-nhpjvgt4 34 28 21 21 CD cord-254580-nhpjvgt4 34 29 associated associate VBN cord-254580-nhpjvgt4 34 30 deaths death NNS cord-254580-nhpjvgt4 34 31 . . . cord-254580-nhpjvgt4 35 1 8 8 CD cord-254580-nhpjvgt4 36 1 In in IN cord-254580-nhpjvgt4 36 2 a a DT cord-254580-nhpjvgt4 36 3 meta meta JJ cord-254580-nhpjvgt4 36 4 - - HYPH cord-254580-nhpjvgt4 36 5 analysis analysis NN cord-254580-nhpjvgt4 36 6 of of IN cord-254580-nhpjvgt4 36 7 corticosteroid corticosteroid NN cord-254580-nhpjvgt4 36 8 use use NN cord-254580-nhpjvgt4 36 9 in in IN cord-254580-nhpjvgt4 36 10 patients patient NNS cord-254580-nhpjvgt4 36 11 with with IN cord-254580-nhpjvgt4 36 12 influenza influenza NN cord-254580-nhpjvgt4 36 13 pneumonia pneumonia NN cord-254580-nhpjvgt4 36 14 ( ( -LRB- cord-254580-nhpjvgt4 36 15 10 10 CD cord-254580-nhpjvgt4 36 16 studies study NNS cord-254580-nhpjvgt4 36 17 , , , cord-254580-nhpjvgt4 36 18 n=6548 n=6548 CD cord-254580-nhpjvgt4 36 19 ) ) -RRB- cord-254580-nhpjvgt4 36 20 , , , cord-254580-nhpjvgt4 36 21 compared compare VBN cord-254580-nhpjvgt4 36 22 with with IN cord-254580-nhpjvgt4 36 23 placebo placebo NN cord-254580-nhpjvgt4 36 24 , , , cord-254580-nhpjvgt4 36 25 corticosteroids corticosteroid NNS cord-254580-nhpjvgt4 36 26 were be VBD cord-254580-nhpjvgt4 36 27 associated associate VBN cord-254580-nhpjvgt4 36 28 with with IN cord-254580-nhpjvgt4 36 29 higher high JJR cord-254580-nhpjvgt4 36 30 mortality mortality NN cord-254580-nhpjvgt4 36 31 , , , cord-254580-nhpjvgt4 36 32 longer long RBR cord-254580-nhpjvgt4 36 33 intensive intensive JJ cord-254580-nhpjvgt4 36 34 care care NN cord-254580-nhpjvgt4 36 35 unit unit NN cord-254580-nhpjvgt4 36 36 length length NN cord-254580-nhpjvgt4 36 37 of of IN cord-254580-nhpjvgt4 36 38 stay stay NN cord-254580-nhpjvgt4 36 39 and and CC cord-254580-nhpjvgt4 36 40 a a DT cord-254580-nhpjvgt4 36 41 higher high JJR cord-254580-nhpjvgt4 36 42 rate rate NN cord-254580-nhpjvgt4 36 43 of of IN cord-254580-nhpjvgt4 36 44 secondary secondary JJ cord-254580-nhpjvgt4 36 45 infection infection NN cord-254580-nhpjvgt4 36 46 . . . cord-254580-nhpjvgt4 37 1 9 9 CD cord-254580-nhpjvgt4 38 1 Therefore therefore RB cord-254580-nhpjvgt4 38 2 , , , cord-254580-nhpjvgt4 38 3 oral oral JJ cord-254580-nhpjvgt4 38 4 corticosteroids corticosteroid NNS cord-254580-nhpjvgt4 38 5 should should MD cord-254580-nhpjvgt4 38 6 be be VB cord-254580-nhpjvgt4 38 7 avoided avoid VBN cord-254580-nhpjvgt4 38 8 , , , cord-254580-nhpjvgt4 38 9 weighing weigh VBG cord-254580-nhpjvgt4 38 10 the the DT cord-254580-nhpjvgt4 38 11 risks risk NNS cord-254580-nhpjvgt4 38 12 of of IN cord-254580-nhpjvgt4 38 13 disease disease NN cord-254580-nhpjvgt4 38 14 flare flare NN cord-254580-nhpjvgt4 38 15 vs. vs. FW cord-254580-nhpjvgt4 38 16 SARS SARS NNP cord-254580-nhpjvgt4 38 17 - - HYPH cord-254580-nhpjvgt4 38 18 CoV-2 CoV-2 NNP cord-254580-nhpjvgt4 38 19 infection infection NN cord-254580-nhpjvgt4 38 20 , , , cord-254580-nhpjvgt4 38 21 to to TO cord-254580-nhpjvgt4 38 22 prevent prevent VB cord-254580-nhpjvgt4 38 23 COVID-19 covid-19 JJ cord-254580-nhpjvgt4 38 24 susceptibility susceptibility NN cord-254580-nhpjvgt4 38 25 . . . cord-254580-nhpjvgt4 39 1 Before before IN cord-254580-nhpjvgt4 39 2 discontinuation discontinuation NN cord-254580-nhpjvgt4 39 3 , , , cord-254580-nhpjvgt4 39 4 dose dose NN cord-254580-nhpjvgt4 39 5 tapering tapering NN cord-254580-nhpjvgt4 39 6 may may MD cord-254580-nhpjvgt4 39 7 be be VB cord-254580-nhpjvgt4 39 8 considered consider VBN cord-254580-nhpjvgt4 39 9 to to TO cord-254580-nhpjvgt4 39 10 avoid avoid VB cord-254580-nhpjvgt4 39 11 a a DT cord-254580-nhpjvgt4 39 12 negative negative JJ cord-254580-nhpjvgt4 39 13 effect effect NN cord-254580-nhpjvgt4 39 14 on on IN cord-254580-nhpjvgt4 39 15 respiratory respiratory JJ cord-254580-nhpjvgt4 39 16 symptoms symptom NNS cord-254580-nhpjvgt4 39 17 . . . cord-254580-nhpjvgt4 40 1 Methotrexate Methotrexate NNP cord-254580-nhpjvgt4 40 2 and and CC cord-254580-nhpjvgt4 40 3 cyclosporine cyclosporine NN cord-254580-nhpjvgt4 40 4 are be VBP cord-254580-nhpjvgt4 40 5 amongst amongst IN cord-254580-nhpjvgt4 40 6 the the DT cord-254580-nhpjvgt4 40 7 most most RBS cord-254580-nhpjvgt4 40 8 frequently frequently RB cord-254580-nhpjvgt4 40 9 used use VBN cord-254580-nhpjvgt4 40 10 systemic systemic JJ cord-254580-nhpjvgt4 40 11 medications medication NNS cord-254580-nhpjvgt4 40 12 for for IN cord-254580-nhpjvgt4 40 13 psoriasis psoriasis NN cord-254580-nhpjvgt4 40 14 and and CC cord-254580-nhpjvgt4 40 15 AD ad NN cord-254580-nhpjvgt4 40 16 , , , cord-254580-nhpjvgt4 40 17 with with IN cord-254580-nhpjvgt4 40 18 both both DT cord-254580-nhpjvgt4 40 19 associated associate VBN cord-254580-nhpjvgt4 40 20 with with IN cord-254580-nhpjvgt4 40 21 increased increase VBN cord-254580-nhpjvgt4 40 22 infection infection NN cord-254580-nhpjvgt4 40 23 rates rate NNS cord-254580-nhpjvgt4 40 24 . . . cord-254580-nhpjvgt4 41 1 There there EX cord-254580-nhpjvgt4 41 2 was be VBD cord-254580-nhpjvgt4 41 3 a a DT cord-254580-nhpjvgt4 41 4 58 58 CD cord-254580-nhpjvgt4 41 5 % % NN cord-254580-nhpjvgt4 41 6 higher high JJR cord-254580-nhpjvgt4 41 7 overall overall JJ cord-254580-nhpjvgt4 41 8 infection infection NN cord-254580-nhpjvgt4 41 9 risk risk NN cord-254580-nhpjvgt4 41 10 with with IN cord-254580-nhpjvgt4 41 11 cyclosporine cyclosporine NN cord-254580-nhpjvgt4 41 12 vs. vs. FW cord-254580-nhpjvgt4 41 13 methotrexate methotrexate NNP cord-254580-nhpjvgt4 41 14 in in IN cord-254580-nhpjvgt4 41 15 the the DT cord-254580-nhpjvgt4 41 16 BIOBADADERM BIOBADADERM NNP cord-254580-nhpjvgt4 41 17 registry registry NN cord-254580-nhpjvgt4 41 18 ( ( -LRB- cord-254580-nhpjvgt4 41 19 Spanish Spanish NNP cord-254580-nhpjvgt4 41 20 Registry Registry NNP cord-254580-nhpjvgt4 41 21 of of IN cord-254580-nhpjvgt4 41 22 Adverse adverse JJ cord-254580-nhpjvgt4 41 23 Events event NNS cord-254580-nhpjvgt4 41 24 for for IN cord-254580-nhpjvgt4 41 25 Biological Biological NNP cord-254580-nhpjvgt4 41 26 Therapy Therapy NNP cord-254580-nhpjvgt4 41 27 in in IN cord-254580-nhpjvgt4 41 28 Dermatological Dermatological NNP cord-254580-nhpjvgt4 41 29 Disease Disease NNP cord-254580-nhpjvgt4 41 30 ) ) -RRB- cord-254580-nhpjvgt4 41 31 including include VBG cord-254580-nhpjvgt4 41 32 2153 2153 CD cord-254580-nhpjvgt4 41 33 psoriasis psoriasis NN cord-254580-nhpjvgt4 41 34 patients patient NNS cord-254580-nhpjvgt4 41 35 . . . cord-254580-nhpjvgt4 42 1 10 10 CD cord-254580-nhpjvgt4 43 1 In in IN cord-254580-nhpjvgt4 43 2 a a DT cord-254580-nhpjvgt4 43 3 head head NN cord-254580-nhpjvgt4 43 4 - - HYPH cord-254580-nhpjvgt4 43 5 to to IN cord-254580-nhpjvgt4 43 6 - - HYPH cord-254580-nhpjvgt4 43 7 head head NN cord-254580-nhpjvgt4 43 8 comparison comparison NN cord-254580-nhpjvgt4 43 9 of of IN cord-254580-nhpjvgt4 43 10 methotrexate methotrexate NNP cord-254580-nhpjvgt4 43 11 ( ( -LRB- cord-254580-nhpjvgt4 43 12 n=50 n=50 NNP cord-254580-nhpjvgt4 43 13 ) ) -RRB- cord-254580-nhpjvgt4 43 14 versus versus IN cord-254580-nhpjvgt4 43 15 cyclosporine cyclosporine NN cord-254580-nhpjvgt4 43 16 ( ( -LRB- cord-254580-nhpjvgt4 43 17 n=47 n=47 NN cord-254580-nhpjvgt4 43 18 ) ) -RRB- cord-254580-nhpjvgt4 43 19 in in IN cord-254580-nhpjvgt4 43 20 moderate moderate JJ cord-254580-nhpjvgt4 43 21 to to IN cord-254580-nhpjvgt4 43 22 severe severe JJ cord-254580-nhpjvgt4 43 23 AD ad NN cord-254580-nhpjvgt4 43 24 adults adult NNS cord-254580-nhpjvgt4 43 25 , , , cord-254580-nhpjvgt4 43 26 infections infection NNS cord-254580-nhpjvgt4 43 27 rates rate NNS cord-254580-nhpjvgt4 43 28 were be VBD cord-254580-nhpjvgt4 43 29 32 32 CD cord-254580-nhpjvgt4 43 30 % % NN cord-254580-nhpjvgt4 43 31 and and CC cord-254580-nhpjvgt4 43 32 24 24 CD cord-254580-nhpjvgt4 43 33 % % NN cord-254580-nhpjvgt4 43 34 , , , cord-254580-nhpjvgt4 43 35 respectively respectively RB cord-254580-nhpjvgt4 43 36 . . . cord-254580-nhpjvgt4 44 1 11 11 CD cord-254580-nhpjvgt4 45 1 While while IN cord-254580-nhpjvgt4 45 2 methotrexate methotrexate NNP cord-254580-nhpjvgt4 45 3 and and CC cord-254580-nhpjvgt4 45 4 cyclosporine cyclosporine NN cord-254580-nhpjvgt4 45 5 are be VBP cord-254580-nhpjvgt4 45 6 associated associate VBN cord-254580-nhpjvgt4 45 7 with with IN cord-254580-nhpjvgt4 45 8 decreased decrease VBN cord-254580-nhpjvgt4 45 9 infection infection NN cord-254580-nhpjvgt4 45 10 rates rate NNS cord-254580-nhpjvgt4 45 11 and and CC cord-254580-nhpjvgt4 45 12 favored favor VBN cord-254580-nhpjvgt4 45 13 over over IN cord-254580-nhpjvgt4 45 14 treatment treatment NN cord-254580-nhpjvgt4 45 15 with with IN cord-254580-nhpjvgt4 45 16 systemic systemic JJ cord-254580-nhpjvgt4 45 17 corticosteroids corticosteroid NNS cord-254580-nhpjvgt4 45 18 , , , cord-254580-nhpjvgt4 45 19 12 12 CD cord-254580-nhpjvgt4 45 20 their -PRON- PRP$ cord-254580-nhpjvgt4 45 21 impact impact NN cord-254580-nhpjvgt4 45 22 on on IN cord-254580-nhpjvgt4 45 23 susceptibility susceptibility NN cord-254580-nhpjvgt4 45 24 to to IN cord-254580-nhpjvgt4 45 25 / / SYM cord-254580-nhpjvgt4 45 26 severity severity NN cord-254580-nhpjvgt4 45 27 of of IN cord-254580-nhpjvgt4 45 28 COVID-19 COVID-19 NNP cord-254580-nhpjvgt4 45 29 is be VBZ cord-254580-nhpjvgt4 45 30 unknown unknown JJ cord-254580-nhpjvgt4 45 31 and and CC cord-254580-nhpjvgt4 45 32 , , , cord-254580-nhpjvgt4 45 33 if if IN cord-254580-nhpjvgt4 45 34 essential essential JJ cord-254580-nhpjvgt4 45 35 , , , cord-254580-nhpjvgt4 45 36 precautions precaution NNS cord-254580-nhpjvgt4 45 37 should should MD cord-254580-nhpjvgt4 45 38 be be VB cord-254580-nhpjvgt4 45 39 taken take VBN cord-254580-nhpjvgt4 45 40 to to TO cord-254580-nhpjvgt4 45 41 avoid avoid VB cord-254580-nhpjvgt4 45 42 infection infection NN cord-254580-nhpjvgt4 45 43 . . . cord-254580-nhpjvgt4 46 1 Of of IN cord-254580-nhpjvgt4 46 2 interest interest NN cord-254580-nhpjvgt4 46 3 , , , cord-254580-nhpjvgt4 46 4 cyclosporine cyclosporine NN cord-254580-nhpjvgt4 46 5 has have VBZ cord-254580-nhpjvgt4 46 6 anti anti JJ cord-254580-nhpjvgt4 46 7 - - JJ cord-254580-nhpjvgt4 46 8 coronavirus coronavirus JJ cord-254580-nhpjvgt4 46 9 activity activity NN cord-254580-nhpjvgt4 46 10 in in IN cord-254580-nhpjvgt4 46 11 vitro vitro FW cord-254580-nhpjvgt4 46 12 , , , cord-254580-nhpjvgt4 46 13 but but CC cord-254580-nhpjvgt4 46 14 the the DT cord-254580-nhpjvgt4 46 15 effect effect NN cord-254580-nhpjvgt4 46 16 in in IN cord-254580-nhpjvgt4 46 17 humans human NNS cord-254580-nhpjvgt4 46 18 is be VBZ cord-254580-nhpjvgt4 46 19 unknown unknown JJ cord-254580-nhpjvgt4 46 20 . . . cord-254580-nhpjvgt4 47 1 13 13 CD cord-254580-nhpjvgt4 48 1 The the DT cord-254580-nhpjvgt4 48 2 systemic systemic JJ cord-254580-nhpjvgt4 48 3 retinoid retinoid NN cord-254580-nhpjvgt4 48 4 , , , cord-254580-nhpjvgt4 48 5 acitretin acitretin NNP cord-254580-nhpjvgt4 48 6 , , , cord-254580-nhpjvgt4 48 7 is be VBZ cord-254580-nhpjvgt4 48 8 anti anti JJ cord-254580-nhpjvgt4 48 9 - - JJ cord-254580-nhpjvgt4 48 10 inflammatory inflammatory JJ cord-254580-nhpjvgt4 48 11 and and CC cord-254580-nhpjvgt4 48 12 inhibits inhibit VBZ cord-254580-nhpjvgt4 48 13 cell cell NN cord-254580-nhpjvgt4 48 14 differentiation differentiation NN cord-254580-nhpjvgt4 48 15 ; ; : cord-254580-nhpjvgt4 48 16 it -PRON- PRP cord-254580-nhpjvgt4 48 17 is be VBZ cord-254580-nhpjvgt4 48 18 Food Food NNP cord-254580-nhpjvgt4 48 19 and and CC cord-254580-nhpjvgt4 48 20 Drug Drug NNP cord-254580-nhpjvgt4 48 21 Administration Administration NNP cord-254580-nhpjvgt4 48 22 ( ( -LRB- cord-254580-nhpjvgt4 48 23 FDA)-approved fda)-approve VBN cord-254580-nhpjvgt4 48 24 for for IN cord-254580-nhpjvgt4 48 25 psoriasis psoriasis NN cord-254580-nhpjvgt4 48 26 . . . cord-254580-nhpjvgt4 49 1 14 14 CD cord-254580-nhpjvgt4 50 1 It -PRON- PRP cord-254580-nhpjvgt4 50 2 does do VBZ cord-254580-nhpjvgt4 50 3 not not RB cord-254580-nhpjvgt4 50 4 suppress suppress VB cord-254580-nhpjvgt4 50 5 the the DT cord-254580-nhpjvgt4 50 6 immune immune JJ cord-254580-nhpjvgt4 50 7 system system NN cord-254580-nhpjvgt4 50 8 to to IN cord-254580-nhpjvgt4 50 9 the the DT cord-254580-nhpjvgt4 50 10 extent extent NN cord-254580-nhpjvgt4 50 11 of of IN cord-254580-nhpjvgt4 50 12 the the DT cord-254580-nhpjvgt4 50 13 other other JJ cord-254580-nhpjvgt4 50 14 conventional conventional JJ cord-254580-nhpjvgt4 50 15 treatments treatment NNS cord-254580-nhpjvgt4 50 16 for for IN cord-254580-nhpjvgt4 50 17 psoriasis psoriasis NN cord-254580-nhpjvgt4 50 18 . . . cord-254580-nhpjvgt4 51 1 In in IN cord-254580-nhpjvgt4 51 2 an an DT cord-254580-nhpjvgt4 51 3 observational observational JJ cord-254580-nhpjvgt4 51 4 cohort cohort NN cord-254580-nhpjvgt4 51 5 study study NN cord-254580-nhpjvgt4 51 6 , , , cord-254580-nhpjvgt4 51 7 there there EX cord-254580-nhpjvgt4 51 8 was be VBD cord-254580-nhpjvgt4 51 9 no no DT cord-254580-nhpjvgt4 51 10 increased increase VBN cord-254580-nhpjvgt4 51 11 rate rate NN cord-254580-nhpjvgt4 51 12 of of IN cord-254580-nhpjvgt4 51 13 overall overall JJ cord-254580-nhpjvgt4 51 14 serious serious JJ cord-254580-nhpjvgt4 51 15 infections infection NNS cord-254580-nhpjvgt4 51 16 among among IN cord-254580-nhpjvgt4 51 17 acitretin acitretin NN cord-254580-nhpjvgt4 51 18 - - HYPH cord-254580-nhpjvgt4 51 19 treated treat VBN cord-254580-nhpjvgt4 51 20 psoriasis psoriasis NN cord-254580-nhpjvgt4 51 21 patients patient NNS cord-254580-nhpjvgt4 51 22 vs. vs. IN cord-254580-nhpjvgt4 51 23 methotrexate methotrexate NNP cord-254580-nhpjvgt4 51 24 ; ; : cord-254580-nhpjvgt4 51 25 acitretin acitretin NNP cord-254580-nhpjvgt4 51 26 increased increase VBD cord-254580-nhpjvgt4 51 27 risk risk NN cord-254580-nhpjvgt4 51 28 of of IN cord-254580-nhpjvgt4 51 29 cellulitis cellulitis NN cord-254580-nhpjvgt4 51 30 compared compare VBN cord-254580-nhpjvgt4 51 31 to to IN cord-254580-nhpjvgt4 51 32 methotrexate methotrexate NNP cord-254580-nhpjvgt4 51 33 ( ( -LRB- cord-254580-nhpjvgt4 51 34 propensity propensity NN cord-254580-nhpjvgt4 51 35 score score RB cord-254580-nhpjvgt4 51 36 - - HYPH cord-254580-nhpjvgt4 51 37 adjusted adjust VBN cord-254580-nhpjvgt4 51 38 hazard hazard NN cord-254580-nhpjvgt4 51 39 ratio ratio NN cord-254580-nhpjvgt4 51 40 [ [ -LRB- cord-254580-nhpjvgt4 51 41 HR HR NNP cord-254580-nhpjvgt4 51 42 ] ] -RRB- cord-254580-nhpjvgt4 51 43 , , , cord-254580-nhpjvgt4 51 44 1.76 1.76 CD cord-254580-nhpjvgt4 51 45 ; ; . cord-254580-nhpjvgt4 52 1 95 95 CD cord-254580-nhpjvgt4 52 2 % % NN cord-254580-nhpjvgt4 52 3 CI CI NNP cord-254580-nhpjvgt4 52 4 , , , cord-254580-nhpjvgt4 52 5 1.11 1.11 CD cord-254580-nhpjvgt4 52 6 - - SYM cord-254580-nhpjvgt4 52 7 2.80 2.80 CD cord-254580-nhpjvgt4 52 8 ) ) -RRB- cord-254580-nhpjvgt4 52 9 , , , cord-254580-nhpjvgt4 52 10 possibly possibly RB cord-254580-nhpjvgt4 52 11 due due JJ cord-254580-nhpjvgt4 52 12 to to IN cord-254580-nhpjvgt4 52 13 skin skin NN cord-254580-nhpjvgt4 52 14 fragility fragility NN cord-254580-nhpjvgt4 52 15 and and CC cord-254580-nhpjvgt4 52 16 staphylococcus staphylococcus NN cord-254580-nhpjvgt4 52 17 aureus aureus NNP cord-254580-nhpjvgt4 52 18 colonization colonization NN cord-254580-nhpjvgt4 52 19 . . . cord-254580-nhpjvgt4 53 1 15 15 CD cord-254580-nhpjvgt4 54 1 Therefore therefore RB cord-254580-nhpjvgt4 54 2 , , , cord-254580-nhpjvgt4 54 3 acitretin acitretin NNP cord-254580-nhpjvgt4 54 4 has have VBZ cord-254580-nhpjvgt4 54 5 not not RB cord-254580-nhpjvgt4 54 6 shown show VBN cord-254580-nhpjvgt4 54 7 increased increase VBN cord-254580-nhpjvgt4 54 8 viral viral JJ cord-254580-nhpjvgt4 54 9 / / SYM cord-254580-nhpjvgt4 54 10 respiratory respiratory JJ cord-254580-nhpjvgt4 54 11 infection infection NN cord-254580-nhpjvgt4 54 12 risk risk NN cord-254580-nhpjvgt4 54 13 and and CC cord-254580-nhpjvgt4 54 14 can can MD cord-254580-nhpjvgt4 54 15 be be VB cord-254580-nhpjvgt4 54 16 safely safely RB cord-254580-nhpjvgt4 54 17 used use VBN cord-254580-nhpjvgt4 54 18 during during IN cord-254580-nhpjvgt4 54 19 the the DT cord-254580-nhpjvgt4 54 20 pandemic pandemic NN cord-254580-nhpjvgt4 54 21 . . . cord-254580-nhpjvgt4 55 1 Retinoids retinoid NNS cord-254580-nhpjvgt4 55 2 have have VBP cord-254580-nhpjvgt4 55 3 been be VBN cord-254580-nhpjvgt4 55 4 shown show VBN cord-254580-nhpjvgt4 55 5 to to TO cord-254580-nhpjvgt4 55 6 inhibit inhibit VB cord-254580-nhpjvgt4 55 7 human human JJ cord-254580-nhpjvgt4 55 8 herpesvirus herpesvirus NN cord-254580-nhpjvgt4 55 9 eight eight CD cord-254580-nhpjvgt4 55 10 replication replication NN cord-254580-nhpjvgt4 55 11 , , , cord-254580-nhpjvgt4 56 1 their -PRON- PRP$ cord-254580-nhpjvgt4 56 2 effect effect NN cord-254580-nhpjvgt4 56 3 on on IN cord-254580-nhpjvgt4 56 4 SARS SARS NNP cord-254580-nhpjvgt4 56 5 - - HYPH cord-254580-nhpjvgt4 56 6 CoV-2 CoV-2 NNP cord-254580-nhpjvgt4 56 7 remains remain VBZ cord-254580-nhpjvgt4 56 8 to to TO cord-254580-nhpjvgt4 56 9 be be VB cord-254580-nhpjvgt4 56 10 established establish VBN cord-254580-nhpjvgt4 56 11 . . . cord-254580-nhpjvgt4 57 1 16 16 CD cord-254580-nhpjvgt4 57 2 _SP cord-254580-nhpjvgt4 58 1 This this DT cord-254580-nhpjvgt4 58 2 article article NN cord-254580-nhpjvgt4 58 3 is be VBZ cord-254580-nhpjvgt4 58 4 protected protect VBN cord-254580-nhpjvgt4 58 5 by by IN cord-254580-nhpjvgt4 58 6 copyright copyright NN cord-254580-nhpjvgt4 58 7 . . . cord-254580-nhpjvgt4 59 1 All all DT cord-254580-nhpjvgt4 59 2 rights right NNS cord-254580-nhpjvgt4 59 3 reserved reserve VBN cord-254580-nhpjvgt4 59 4 . . . cord-254580-nhpjvgt4 60 1 Azathioprine Azathioprine NNP cord-254580-nhpjvgt4 60 2 is be VBZ cord-254580-nhpjvgt4 60 3 used use VBN cord-254580-nhpjvgt4 60 4 off off IN cord-254580-nhpjvgt4 60 5 - - HYPH cord-254580-nhpjvgt4 60 6 label label NN cord-254580-nhpjvgt4 60 7 in in IN cord-254580-nhpjvgt4 60 8 the the DT cord-254580-nhpjvgt4 60 9 US US NNP cord-254580-nhpjvgt4 60 10 for for IN cord-254580-nhpjvgt4 60 11 AD ad NN cord-254580-nhpjvgt4 60 12 treatment treatment NN cord-254580-nhpjvgt4 60 13 in in IN cord-254580-nhpjvgt4 60 14 patients patient NNS cord-254580-nhpjvgt4 60 15 recalcitrant recalcitrant JJ cord-254580-nhpjvgt4 60 16 or or CC cord-254580-nhpjvgt4 60 17 who who WP cord-254580-nhpjvgt4 60 18 have have VBP cord-254580-nhpjvgt4 60 19 contraindications contraindication NNS cord-254580-nhpjvgt4 60 20 to to IN cord-254580-nhpjvgt4 60 21 cyclosporine cyclosporine NN cord-254580-nhpjvgt4 60 22 and and CC cord-254580-nhpjvgt4 60 23 methotrexate methotrexate NNP cord-254580-nhpjvgt4 60 24 . . . cord-254580-nhpjvgt4 61 1 In in IN cord-254580-nhpjvgt4 61 2 12 12 CD cord-254580-nhpjvgt4 61 3 AD ad NN cord-254580-nhpjvgt4 61 4 children child NNS cord-254580-nhpjvgt4 61 5 treated treat VBN cord-254580-nhpjvgt4 61 6 with with IN cord-254580-nhpjvgt4 61 7 azathioprine azathioprine NN cord-254580-nhpjvgt4 61 8 , , , cord-254580-nhpjvgt4 61 9 there there EX cord-254580-nhpjvgt4 61 10 were be VBD cord-254580-nhpjvgt4 61 11 no no DT cord-254580-nhpjvgt4 61 12 associated associate VBN cord-254580-nhpjvgt4 61 13 infections infection NNS cord-254580-nhpjvgt4 61 14 . . . cord-254580-nhpjvgt4 62 1 17 17 CD cord-254580-nhpjvgt4 63 1 In in IN cord-254580-nhpjvgt4 63 2 a a DT cord-254580-nhpjvgt4 63 3 double double JJ cord-254580-nhpjvgt4 63 4 - - HYPH cord-254580-nhpjvgt4 63 5 blind blind JJ cord-254580-nhpjvgt4 63 6 , , , cord-254580-nhpjvgt4 63 7 placebo placebo NN cord-254580-nhpjvgt4 63 8 - - HYPH cord-254580-nhpjvgt4 63 9 controlled control VBN cord-254580-nhpjvgt4 63 10 , , , cord-254580-nhpjvgt4 63 11 crossover crossover NN cord-254580-nhpjvgt4 63 12 study study NN cord-254580-nhpjvgt4 63 13 of of IN cord-254580-nhpjvgt4 63 14 37 37 CD cord-254580-nhpjvgt4 63 15 AD ad NN cord-254580-nhpjvgt4 63 16 adults adult NNS cord-254580-nhpjvgt4 63 17 treated treat VBN cord-254580-nhpjvgt4 63 18 with with IN cord-254580-nhpjvgt4 63 19 azathioprine azathioprine NN cord-254580-nhpjvgt4 63 20 , , , cord-254580-nhpjvgt4 63 21 there there EX cord-254580-nhpjvgt4 63 22 were be VBD cord-254580-nhpjvgt4 63 23 five five CD cord-254580-nhpjvgt4 63 24 cases case NNS cord-254580-nhpjvgt4 63 25 of of IN cord-254580-nhpjvgt4 63 26 upper upper JJ cord-254580-nhpjvgt4 63 27 respiratory respiratory JJ cord-254580-nhpjvgt4 63 28 infections infection NNS cord-254580-nhpjvgt4 63 29 ( ( -LRB- cord-254580-nhpjvgt4 63 30 URIs URIs NNP cord-254580-nhpjvgt4 63 31 ) ) -RRB- cord-254580-nhpjvgt4 63 32 ( ( -LRB- cord-254580-nhpjvgt4 63 33 14 14 CD cord-254580-nhpjvgt4 63 34 % % NN cord-254580-nhpjvgt4 63 35 ) ) -RRB- cord-254580-nhpjvgt4 63 36 , , , cord-254580-nhpjvgt4 63 37 two two CD cord-254580-nhpjvgt4 63 38 cases case NNS cord-254580-nhpjvgt4 63 39 folliculitis folliculitis VBP cord-254580-nhpjvgt4 63 40 ( ( -LRB- cord-254580-nhpjvgt4 63 41 5 5 CD cord-254580-nhpjvgt4 63 42 % % NN cord-254580-nhpjvgt4 63 43 ) ) -RRB- cord-254580-nhpjvgt4 63 44 , , , cord-254580-nhpjvgt4 63 45 and and CC cord-254580-nhpjvgt4 63 46 one one CD cord-254580-nhpjvgt4 63 47 report report NN cord-254580-nhpjvgt4 63 48 each each DT cord-254580-nhpjvgt4 63 49 impetigo impetigo NNS cord-254580-nhpjvgt4 63 50 ( ( -LRB- cord-254580-nhpjvgt4 63 51 3 3 CD cord-254580-nhpjvgt4 63 52 % % NN cord-254580-nhpjvgt4 63 53 ) ) -RRB- cord-254580-nhpjvgt4 63 54 and and CC cord-254580-nhpjvgt4 63 55 sore sore JJ cord-254580-nhpjvgt4 63 56 throat throat NN cord-254580-nhpjvgt4 63 57 ( ( -LRB- cord-254580-nhpjvgt4 63 58 3 3 CD cord-254580-nhpjvgt4 63 59 % % NN cord-254580-nhpjvgt4 63 60 ) ) -RRB- cord-254580-nhpjvgt4 63 61 . . . cord-254580-nhpjvgt4 64 1 18 18 CD cord-254580-nhpjvgt4 65 1 In in IN cord-254580-nhpjvgt4 65 2 a a DT cord-254580-nhpjvgt4 65 3 retrospective retrospective JJ cord-254580-nhpjvgt4 65 4 analysis analysis NN cord-254580-nhpjvgt4 65 5 of of IN cord-254580-nhpjvgt4 65 6 232,611 232,611 CD cord-254580-nhpjvgt4 65 7 systemically systemically RB cord-254580-nhpjvgt4 65 8 - - HYPH cord-254580-nhpjvgt4 65 9 treated treat VBN cord-254580-nhpjvgt4 65 10 adults adult NNS cord-254580-nhpjvgt4 65 11 with with IN cord-254580-nhpjvgt4 65 12 AD ad NN cord-254580-nhpjvgt4 65 13 ( ( -LRB- cord-254580-nhpjvgt4 65 14 six six CD cord-254580-nhpjvgt4 65 15 months month NNS cord-254580-nhpjvgt4 65 16 ) ) -RRB- cord-254580-nhpjvgt4 65 17 , , , cord-254580-nhpjvgt4 65 18 there there EX cord-254580-nhpjvgt4 65 19 were be VBD cord-254580-nhpjvgt4 65 20 increased increase VBN cord-254580-nhpjvgt4 65 21 risks risk NNS cord-254580-nhpjvgt4 65 22 of of IN cord-254580-nhpjvgt4 65 23 serious serious JJ cord-254580-nhpjvgt4 65 24 and and CC cord-254580-nhpjvgt4 65 25 opportunistic opportunistic JJ cord-254580-nhpjvgt4 65 26 infections infection NNS cord-254580-nhpjvgt4 65 27 with with IN cord-254580-nhpjvgt4 65 28 azathioprine azathioprine NN cord-254580-nhpjvgt4 65 29 ( ( -LRB- cord-254580-nhpjvgt4 65 30 RR=1.89 RR=1.89 NNS cord-254580-nhpjvgt4 65 31 ) ) -RRB- cord-254580-nhpjvgt4 65 32 and and CC cord-254580-nhpjvgt4 65 33 prednisone prednisone NNP cord-254580-nhpjvgt4 65 34 ( ( -LRB- cord-254580-nhpjvgt4 65 35 RR=1.78 RR=1.78 NFP cord-254580-nhpjvgt4 65 36 ) ) -RRB- cord-254580-nhpjvgt4 65 37 compared compare VBN cord-254580-nhpjvgt4 65 38 with with IN cord-254580-nhpjvgt4 65 39 methotrexate methotrexate NNP cord-254580-nhpjvgt4 65 40 , , , cord-254580-nhpjvgt4 65 41 with with IN cord-254580-nhpjvgt4 65 42 a a DT cord-254580-nhpjvgt4 65 43 reduced reduce VBN cord-254580-nhpjvgt4 65 44 risk risk NN cord-254580-nhpjvgt4 65 45 with with IN cord-254580-nhpjvgt4 65 46 cyclosporine cyclosporine NN cord-254580-nhpjvgt4 65 47 ( ( -LRB- cord-254580-nhpjvgt4 65 48 RR=0.87 RR=0.87 NNP cord-254580-nhpjvgt4 65 49 ) ) -RRB- cord-254580-nhpjvgt4 65 50 . . . cord-254580-nhpjvgt4 66 1 12 12 CD cord-254580-nhpjvgt4 67 1 Therefore therefore RB cord-254580-nhpjvgt4 67 2 , , , cord-254580-nhpjvgt4 67 3 azathioprine azathioprine NN cord-254580-nhpjvgt4 67 4 may may MD cord-254580-nhpjvgt4 67 5 increase increase VB cord-254580-nhpjvgt4 67 6 susceptibility susceptibility NN cord-254580-nhpjvgt4 67 7 to to IN cord-254580-nhpjvgt4 67 8 infections infection NNS cord-254580-nhpjvgt4 67 9 , , , cord-254580-nhpjvgt4 67 10 and and CC cord-254580-nhpjvgt4 67 11 if if IN cord-254580-nhpjvgt4 67 12 essential essential JJ cord-254580-nhpjvgt4 67 13 , , , cord-254580-nhpjvgt4 67 14 exposure exposure NN cord-254580-nhpjvgt4 67 15 to to IN cord-254580-nhpjvgt4 67 16 COVID-19 COVID-19 NNP cord-254580-nhpjvgt4 67 17 should should MD cord-254580-nhpjvgt4 67 18 be be VB cord-254580-nhpjvgt4 67 19 minimized minimize VBN cord-254580-nhpjvgt4 67 20 . . . cord-254580-nhpjvgt4 68 1 Apremilast Apremilast NNP cord-254580-nhpjvgt4 68 2 , , , cord-254580-nhpjvgt4 68 3 an an DT cord-254580-nhpjvgt4 68 4 orally orally RB cord-254580-nhpjvgt4 68 5 administered administer VBN cord-254580-nhpjvgt4 68 6 phosphodiesterase phosphodiesterase NN cord-254580-nhpjvgt4 69 1 four four CD cord-254580-nhpjvgt4 69 2 inhibitor inhibitor NN cord-254580-nhpjvgt4 69 3 is be VBZ cord-254580-nhpjvgt4 69 4 FDA FDA NNP cord-254580-nhpjvgt4 69 5 - - HYPH cord-254580-nhpjvgt4 69 6 approved approve VBN cord-254580-nhpjvgt4 69 7 for for IN cord-254580-nhpjvgt4 69 8 moderate moderate JJ cord-254580-nhpjvgt4 69 9 to to IN cord-254580-nhpjvgt4 69 10 severe severe JJ cord-254580-nhpjvgt4 69 11 plaque plaque NN cord-254580-nhpjvgt4 69 12 psoriasis psoriasis NN cord-254580-nhpjvgt4 69 13 and and CC cord-254580-nhpjvgt4 69 14 has have VBZ cord-254580-nhpjvgt4 69 15 been be VBN cord-254580-nhpjvgt4 69 16 used use VBN cord-254580-nhpjvgt4 69 17 off off IN cord-254580-nhpjvgt4 69 18 - - HYPH cord-254580-nhpjvgt4 69 19 label label NN cord-254580-nhpjvgt4 69 20 for for IN cord-254580-nhpjvgt4 69 21 AD ad NN cord-254580-nhpjvgt4 69 22 . . . cord-254580-nhpjvgt4 70 1 [ [ -LRB- cord-254580-nhpjvgt4 70 2 19 19 CD cord-254580-nhpjvgt4 70 3 ] ] -RRB- cord-254580-nhpjvgt4 70 4 [ [ -LRB- cord-254580-nhpjvgt4 70 5 20 20 CD cord-254580-nhpjvgt4 70 6 ] ] -RRB- cord-254580-nhpjvgt4 70 7 [ [ -LRB- cord-254580-nhpjvgt4 70 8 21 21 CD cord-254580-nhpjvgt4 70 9 ] ] -RRB- cord-254580-nhpjvgt4 71 1 Although although IN cord-254580-nhpjvgt4 71 2 it -PRON- PRP cord-254580-nhpjvgt4 71 3 does do VBZ cord-254580-nhpjvgt4 71 4 modulate modulate VB cord-254580-nhpjvgt4 71 5 immunologic immunologic JJ cord-254580-nhpjvgt4 71 6 cascades cascade NNS cord-254580-nhpjvgt4 71 7 , , , cord-254580-nhpjvgt4 71 8 this this DT cord-254580-nhpjvgt4 71 9 pathway pathway NN cord-254580-nhpjvgt4 71 10 does do VBZ cord-254580-nhpjvgt4 71 11 not not RB cord-254580-nhpjvgt4 71 12 seem seem VB cord-254580-nhpjvgt4 71 13 to to TO cord-254580-nhpjvgt4 71 14 particularly particularly RB cord-254580-nhpjvgt4 71 15 increase increase VB cord-254580-nhpjvgt4 71 16 susceptibility susceptibility NN cord-254580-nhpjvgt4 71 17 to to IN cord-254580-nhpjvgt4 71 18 infection infection NN cord-254580-nhpjvgt4 71 19 . . . cord-254580-nhpjvgt4 72 1 In in IN cord-254580-nhpjvgt4 72 2 a a DT cord-254580-nhpjvgt4 72 3 pooled pool VBN cord-254580-nhpjvgt4 72 4 safety safety NN cord-254580-nhpjvgt4 72 5 analysis analysis NN cord-254580-nhpjvgt4 72 6 of of IN cord-254580-nhpjvgt4 72 7 two two CD cord-254580-nhpjvgt4 72 8 randomized randomized JJ cord-254580-nhpjvgt4 72 9 , , , cord-254580-nhpjvgt4 72 10 controlled control VBN cord-254580-nhpjvgt4 72 11 trials trial NNS cord-254580-nhpjvgt4 72 12 ( ( -LRB- cord-254580-nhpjvgt4 72 13 RCTs RCTs NNP cord-254580-nhpjvgt4 72 14 ) ) -RRB- cord-254580-nhpjvgt4 72 15 involving involve VBG cord-254580-nhpjvgt4 72 16 psoriasis psoriasis NN cord-254580-nhpjvgt4 72 17 patients patient NNS cord-254580-nhpjvgt4 72 18 treated treat VBN cord-254580-nhpjvgt4 72 19 with with IN cord-254580-nhpjvgt4 72 20 apremilast apremilast NNP cord-254580-nhpjvgt4 72 21 ( ( -LRB- cord-254580-nhpjvgt4 72 22 n=1184 n=1184 CD cord-254580-nhpjvgt4 72 23 ) ) -RRB- cord-254580-nhpjvgt4 72 24 , , , cord-254580-nhpjvgt4 72 25 URIs uri NNS cord-254580-nhpjvgt4 72 26 and and CC cord-254580-nhpjvgt4 72 27 nasopharyngitis nasopharyngitis NNP cord-254580-nhpjvgt4 72 28 occurred occur VBD cord-254580-nhpjvgt4 72 29 in in IN cord-254580-nhpjvgt4 72 30 19.2 19.2 CD cord-254580-nhpjvgt4 72 31 % % NN cord-254580-nhpjvgt4 72 32 and and CC cord-254580-nhpjvgt4 72 33 16.6 16.6 CD cord-254580-nhpjvgt4 72 34 % % NN cord-254580-nhpjvgt4 72 35 of of IN cord-254580-nhpjvgt4 72 36 patients patient NNS cord-254580-nhpjvgt4 72 37 , , , cord-254580-nhpjvgt4 72 38 respectively respectively RB cord-254580-nhpjvgt4 72 39 ; ; : cord-254580-nhpjvgt4 72 40 serious serious JJ cord-254580-nhpjvgt4 72 41 infections infection NNS cord-254580-nhpjvgt4 72 42 ( ( -LRB- cord-254580-nhpjvgt4 72 43 urinary urinary JJ cord-254580-nhpjvgt4 72 44 tract tract NN cord-254580-nhpjvgt4 72 45 infection infection NN cord-254580-nhpjvgt4 72 46 n=2 n=2 NNS cord-254580-nhpjvgt4 72 47 ; ; : cord-254580-nhpjvgt4 72 48 appendicitis appendicitis JJ cord-254580-nhpjvgt4 72 49 n=3 n=3 NN cord-254580-nhpjvgt4 72 50 ; ; : cord-254580-nhpjvgt4 72 51 pneumonia=2 pneumonia=2 NNS cord-254580-nhpjvgt4 72 52 ) ) -RRB- cord-254580-nhpjvgt4 72 53 occurred occur VBD cord-254580-nhpjvgt4 72 54 in in IN cord-254580-nhpjvgt4 72 55 1.4 1.4 CD cord-254580-nhpjvgt4 72 56 % % NN cord-254580-nhpjvgt4 72 57 . . . cord-254580-nhpjvgt4 73 1 22 22 CD cord-254580-nhpjvgt4 74 1 Furthermore furthermore RB cord-254580-nhpjvgt4 74 2 , , , cord-254580-nhpjvgt4 74 3 in in IN cord-254580-nhpjvgt4 74 4 an an DT cord-254580-nhpjvgt4 74 5 observational observational JJ cord-254580-nhpjvgt4 74 6 cohort cohort NN cord-254580-nhpjvgt4 74 7 study study NN cord-254580-nhpjvgt4 74 8 including include VBG cord-254580-nhpjvgt4 74 9 systemically systemically RB cord-254580-nhpjvgt4 74 10 treated treat VBN cord-254580-nhpjvgt4 74 11 psoriasis psoriasis NN cord-254580-nhpjvgt4 74 12 patients patient NNS cord-254580-nhpjvgt4 74 13 , , , cord-254580-nhpjvgt4 74 14 overall overall JJ cord-254580-nhpjvgt4 74 15 serious serious JJ cord-254580-nhpjvgt4 74 16 infections infection NNS cord-254580-nhpjvgt4 74 17 were be VBD cord-254580-nhpjvgt4 74 18 decreased decrease VBN cord-254580-nhpjvgt4 74 19 with with IN cord-254580-nhpjvgt4 74 20 apremilast apremilast NNP cord-254580-nhpjvgt4 74 21 vs. vs. FW cord-254580-nhpjvgt4 74 22 methotrexate methotrexate NNP cord-254580-nhpjvgt4 74 23 ( ( -LRB- cord-254580-nhpjvgt4 74 24 HR HR NNP cord-254580-nhpjvgt4 74 25 , , , cord-254580-nhpjvgt4 74 26 0.50 0.50 CD cord-254580-nhpjvgt4 74 27 ; ; : cord-254580-nhpjvgt4 74 28 95 95 CD cord-254580-nhpjvgt4 74 29 % % NN cord-254580-nhpjvgt4 74 30 CI ci NN cord-254580-nhpjvgt4 74 31 , , , cord-254580-nhpjvgt4 74 32 0.26 0.26 CD cord-254580-nhpjvgt4 74 33 - - SYM cord-254580-nhpjvgt4 74 34 0.94 0.94 CD cord-254580-nhpjvgt4 74 35 ) ) -RRB- cord-254580-nhpjvgt4 74 36 . . . cord-254580-nhpjvgt4 75 1 Thus thus RB cord-254580-nhpjvgt4 75 2 , , , cord-254580-nhpjvgt4 75 3 apremilast apremilast NNP cord-254580-nhpjvgt4 75 4 seems seem VBZ cord-254580-nhpjvgt4 75 5 to to TO cord-254580-nhpjvgt4 75 6 be be VB cord-254580-nhpjvgt4 75 7 a a DT cord-254580-nhpjvgt4 75 8 safe safe JJ cord-254580-nhpjvgt4 75 9 alternative alternative NN cord-254580-nhpjvgt4 75 10 for for IN cord-254580-nhpjvgt4 75 11 uninfected uninfected JJ cord-254580-nhpjvgt4 75 12 psoriasis psoriasis NN cord-254580-nhpjvgt4 75 13 patients patient NNS cord-254580-nhpjvgt4 75 14 during during IN cord-254580-nhpjvgt4 75 15 the the DT cord-254580-nhpjvgt4 75 16 pandemic pandemic NN cord-254580-nhpjvgt4 75 17 , , , cord-254580-nhpjvgt4 75 18 but but CC cord-254580-nhpjvgt4 75 19 specific specific JJ cord-254580-nhpjvgt4 75 20 COVID-19 COVID-19 NNP cord-254580-nhpjvgt4 75 21 data datum NNS cord-254580-nhpjvgt4 75 22 is be VBZ cord-254580-nhpjvgt4 75 23 needed need VBN cord-254580-nhpjvgt4 75 24 . . . cord-254580-nhpjvgt4 76 1 Data datum NNS cord-254580-nhpjvgt4 76 2 regarding regard VBG cord-254580-nhpjvgt4 76 3 infection infection NN cord-254580-nhpjvgt4 76 4 risks risk NNS cord-254580-nhpjvgt4 76 5 of of IN cord-254580-nhpjvgt4 76 6 nonbiological nonbiological JJ cord-254580-nhpjvgt4 76 7 therapies therapy NNS cord-254580-nhpjvgt4 76 8 for for IN cord-254580-nhpjvgt4 76 9 psoriasis psoriasis NN cord-254580-nhpjvgt4 76 10 and and CC cord-254580-nhpjvgt4 76 11 AD ad NN cord-254580-nhpjvgt4 76 12 is be VBZ cord-254580-nhpjvgt4 76 13 summarized summarize VBN cord-254580-nhpjvgt4 76 14 in in IN cord-254580-nhpjvgt4 76 15 table table NN cord-254580-nhpjvgt4 76 16 1 1 CD cord-254580-nhpjvgt4 76 17 . . . cord-254580-nhpjvgt4 77 1 Biologic biologic JJ cord-254580-nhpjvgt4 77 2 medications medication NNS cord-254580-nhpjvgt4 77 3 are be VBP cord-254580-nhpjvgt4 77 4 widely widely RB cord-254580-nhpjvgt4 77 5 used use VBN cord-254580-nhpjvgt4 77 6 for for IN cord-254580-nhpjvgt4 77 7 psoriasis psoriasis NN cord-254580-nhpjvgt4 77 8 and and CC cord-254580-nhpjvgt4 77 9 AD ad NN cord-254580-nhpjvgt4 77 10 patients patient NNS cord-254580-nhpjvgt4 77 11 , , , cord-254580-nhpjvgt4 77 12 with with IN cord-254580-nhpjvgt4 77 13 limited limited JJ cord-254580-nhpjvgt4 77 14 data datum NNS cord-254580-nhpjvgt4 77 15 regarding regard VBG cord-254580-nhpjvgt4 77 16 infection infection NN cord-254580-nhpjvgt4 77 17 risk risk NN cord-254580-nhpjvgt4 77 18 . . . cord-254580-nhpjvgt4 78 1 Since since IN cord-254580-nhpjvgt4 78 2 biologics biologic NNS cord-254580-nhpjvgt4 78 3 inhibit inhibit VBP cord-254580-nhpjvgt4 78 4 immune immune JJ cord-254580-nhpjvgt4 78 5 - - HYPH cord-254580-nhpjvgt4 78 6 mediated mediate VBN cord-254580-nhpjvgt4 78 7 pathways pathway NNS cord-254580-nhpjvgt4 78 8 involving involve VBG cord-254580-nhpjvgt4 78 9 specific specific JJ cord-254580-nhpjvgt4 78 10 cytokines cytokine NNS cord-254580-nhpjvgt4 78 11 , , , cord-254580-nhpjvgt4 78 12 there there EX cord-254580-nhpjvgt4 78 13 is be VBZ cord-254580-nhpjvgt4 78 14 at at IN cord-254580-nhpjvgt4 78 15 least least JJS cord-254580-nhpjvgt4 78 16 theoretical theoretical JJ cord-254580-nhpjvgt4 78 17 risk risk NN cord-254580-nhpjvgt4 78 18 of of IN cord-254580-nhpjvgt4 78 19 increased increase VBN cord-254580-nhpjvgt4 78 20 susceptibility susceptibility NN cord-254580-nhpjvgt4 78 21 to to IN cord-254580-nhpjvgt4 78 22 and and CC cord-254580-nhpjvgt4 78 23 severity severity NN cord-254580-nhpjvgt4 78 24 of of IN cord-254580-nhpjvgt4 78 25 infection infection NN cord-254580-nhpjvgt4 78 26 . . . cord-254580-nhpjvgt4 79 1 A a DT cord-254580-nhpjvgt4 79 2 common common JJ cord-254580-nhpjvgt4 79 3 reason reason NN cord-254580-nhpjvgt4 79 4 for for IN cord-254580-nhpjvgt4 79 5 discontinuation discontinuation NN cord-254580-nhpjvgt4 79 6 of of IN cord-254580-nhpjvgt4 79 7 biologics biologic NNS cord-254580-nhpjvgt4 79 8 is be VBZ cord-254580-nhpjvgt4 79 9 infection infection NN cord-254580-nhpjvgt4 79 10 . . . cord-254580-nhpjvgt4 80 1 23 23 CD cord-254580-nhpjvgt4 81 1 Among among IN cord-254580-nhpjvgt4 81 2 the the DT cord-254580-nhpjvgt4 81 3 targeted target VBN cord-254580-nhpjvgt4 81 4 cytokines cytokine NNS cord-254580-nhpjvgt4 81 5 for for IN cord-254580-nhpjvgt4 81 6 these these DT cord-254580-nhpjvgt4 81 7 biologics biologic NNS cord-254580-nhpjvgt4 81 8 , , , cord-254580-nhpjvgt4 81 9 tumor tumor NN cord-254580-nhpjvgt4 81 10 necrosis necrosis NN cord-254580-nhpjvgt4 81 11 factor factor NN cord-254580-nhpjvgt4 81 12 - - HYPH cord-254580-nhpjvgt4 81 13 alpha alpha NN cord-254580-nhpjvgt4 81 14 ( ( -LRB- cord-254580-nhpjvgt4 81 15 TNF TNF NNP cord-254580-nhpjvgt4 81 16 - - HYPH cord-254580-nhpjvgt4 81 17 α α NNP cord-254580-nhpjvgt4 81 18 ) ) -RRB- cord-254580-nhpjvgt4 81 19 plays play VBZ cord-254580-nhpjvgt4 81 20 a a DT cord-254580-nhpjvgt4 81 21 crucial crucial JJ cord-254580-nhpjvgt4 81 22 role role NN cord-254580-nhpjvgt4 81 23 in in IN cord-254580-nhpjvgt4 81 24 the the DT cord-254580-nhpjvgt4 81 25 immune immune JJ cord-254580-nhpjvgt4 81 26 response response NN cord-254580-nhpjvgt4 81 27 against against IN cord-254580-nhpjvgt4 81 28 intracellular intracellular JJ cord-254580-nhpjvgt4 81 29 pathogens pathogen NNS cord-254580-nhpjvgt4 81 30 and and CC cord-254580-nhpjvgt4 81 31 formation formation NN cord-254580-nhpjvgt4 81 32 of of IN cord-254580-nhpjvgt4 81 33 granulomas granuloma NNS cord-254580-nhpjvgt4 81 34 , , , cord-254580-nhpjvgt4 81 35 24 24 CD cord-254580-nhpjvgt4 81 36 and and CC cord-254580-nhpjvgt4 81 37 Interleukin Interleukin NNP cord-254580-nhpjvgt4 81 38 ( ( -LRB- cord-254580-nhpjvgt4 81 39 IL IL NNP cord-254580-nhpjvgt4 81 40 ) ) -RRB- cord-254580-nhpjvgt4 82 1 -12 -12 . cord-254580-nhpjvgt4 83 1 and and CC cord-254580-nhpjvgt4 83 2 IL-23 IL-23 NNP cord-254580-nhpjvgt4 83 3 are be VBP cord-254580-nhpjvgt4 83 4 involved involve VBN cord-254580-nhpjvgt4 83 5 in in IN cord-254580-nhpjvgt4 83 6 cell cell NN cord-254580-nhpjvgt4 83 7 - - HYPH cord-254580-nhpjvgt4 83 8 mediated mediate VBN cord-254580-nhpjvgt4 83 9 immunity immunity NN cord-254580-nhpjvgt4 83 10 by by IN cord-254580-nhpjvgt4 83 11 inducing induce VBG cord-254580-nhpjvgt4 83 12 interferon interferon NN cord-254580-nhpjvgt4 83 13 - - HYPH cord-254580-nhpjvgt4 83 14 γ γ NN cord-254580-nhpjvgt4 83 15 . . . cord-254580-nhpjvgt4 84 1 25 25 CD cord-254580-nhpjvgt4 84 2 IL-23 IL-23 NNP cord-254580-nhpjvgt4 84 3 also also RB cord-254580-nhpjvgt4 84 4 induces induce VBZ cord-254580-nhpjvgt4 84 5 T t NN cord-254580-nhpjvgt4 84 6 - - HYPH cord-254580-nhpjvgt4 84 7 helper helper NN cord-254580-nhpjvgt4 84 8 17 17 CD cord-254580-nhpjvgt4 84 9 cell cell NN cord-254580-nhpjvgt4 84 10 differentiation differentiation NN cord-254580-nhpjvgt4 84 11 and and CC cord-254580-nhpjvgt4 84 12 IL-17secretion IL-17secretion NNP cord-254580-nhpjvgt4 84 13 , , , cord-254580-nhpjvgt4 84 14 fundamental fundamental JJ cord-254580-nhpjvgt4 84 15 in in IN cord-254580-nhpjvgt4 84 16 providing provide VBG cord-254580-nhpjvgt4 84 17 immunity immunity NN cord-254580-nhpjvgt4 84 18 against against IN cord-254580-nhpjvgt4 84 19 bacteria bacteria NNS cord-254580-nhpjvgt4 84 20 , , , cord-254580-nhpjvgt4 84 21 viruses virus NNS cord-254580-nhpjvgt4 84 22 , , , cord-254580-nhpjvgt4 84 23 fungi fungus NNS cord-254580-nhpjvgt4 84 24 and and CC cord-254580-nhpjvgt4 84 25 parasites parasite NNS cord-254580-nhpjvgt4 84 26 . . . cord-254580-nhpjvgt4 85 1 26 26 CD cord-254580-nhpjvgt4 85 2 , , , cord-254580-nhpjvgt4 85 3 27 27 CD cord-254580-nhpjvgt4 85 4 IL-4 IL-4 NNP cord-254580-nhpjvgt4 85 5 and and CC cord-254580-nhpjvgt4 85 6 IL-13 IL-13 NNP cord-254580-nhpjvgt4 85 7 play play VBP cord-254580-nhpjvgt4 85 8 key key JJ cord-254580-nhpjvgt4 85 9 roles role NNS cord-254580-nhpjvgt4 85 10 in in IN cord-254580-nhpjvgt4 85 11 the the DT cord-254580-nhpjvgt4 85 12 immune immune JJ cord-254580-nhpjvgt4 85 13 response response NN cord-254580-nhpjvgt4 85 14 against against IN cord-254580-nhpjvgt4 85 15 helminth helminth JJ cord-254580-nhpjvgt4 85 16 infections infection NNS cord-254580-nhpjvgt4 85 17 . . . cord-254580-nhpjvgt4 86 1 28 28 CD cord-254580-nhpjvgt4 86 2 Five five CD cord-254580-nhpjvgt4 86 3 classes class NNS cord-254580-nhpjvgt4 86 4 of of IN cord-254580-nhpjvgt4 86 5 biologic biologic JJ cord-254580-nhpjvgt4 86 6 therapies therapy NNS cord-254580-nhpjvgt4 86 7 are be VBP cord-254580-nhpjvgt4 86 8 used use VBN cord-254580-nhpjvgt4 86 9 for for IN cord-254580-nhpjvgt4 86 10 psoriasis psoriasis NN cord-254580-nhpjvgt4 86 11 or or CC cord-254580-nhpjvgt4 86 12 AD ad NN cord-254580-nhpjvgt4 86 13 : : : cord-254580-nhpjvgt4 87 1 TNF TNF NNP cord-254580-nhpjvgt4 87 2 - - HYPH cord-254580-nhpjvgt4 87 3 α α NNP cord-254580-nhpjvgt4 87 4 inhibitors inhibitor NNS cord-254580-nhpjvgt4 87 5 ( ( -LRB- cord-254580-nhpjvgt4 87 6 table table NN cord-254580-nhpjvgt4 87 7 2 2 CD cord-254580-nhpjvgt4 87 8 ) ) -RRB- cord-254580-nhpjvgt4 87 9 , , , cord-254580-nhpjvgt4 87 10 IL-17 IL-17 NNP cord-254580-nhpjvgt4 87 11 inhibitors inhibitor NNS cord-254580-nhpjvgt4 87 12 , , , cord-254580-nhpjvgt4 87 13 an an DT cord-254580-nhpjvgt4 87 14 IL-12/23 il-12/23 NN cord-254580-nhpjvgt4 87 15 inhibitor inhibitor NN cord-254580-nhpjvgt4 87 16 , , , cord-254580-nhpjvgt4 87 17 IL-23 IL-23 NNP cord-254580-nhpjvgt4 87 18 inhibitors inhibitor NNS cord-254580-nhpjvgt4 87 19 , , , cord-254580-nhpjvgt4 87 20 an an DT cord-254580-nhpjvgt4 87 21 IL-4/13 il-4/13 NN cord-254580-nhpjvgt4 87 22 inhibitor inhibitor NN cord-254580-nhpjvgt4 87 23 , , , cord-254580-nhpjvgt4 87 24 and and CC cord-254580-nhpjvgt4 87 25 a a DT cord-254580-nhpjvgt4 87 26 Janus Janus NNP cord-254580-nhpjvgt4 87 27 kinase kinase NN cord-254580-nhpjvgt4 87 28 ( ( -LRB- cord-254580-nhpjvgt4 87 29 JAK JAK NNP cord-254580-nhpjvgt4 87 30 ) ) -RRB- cord-254580-nhpjvgt4 87 31 inhibitor inhibitor NN cord-254580-nhpjvgt4 87 32 ( ( -LRB- cord-254580-nhpjvgt4 87 33 table table NN cord-254580-nhpjvgt4 87 34 3 3 CD cord-254580-nhpjvgt4 87 35 ) ) -RRB- cord-254580-nhpjvgt4 87 36 . . . cord-254580-nhpjvgt4 88 1 This this DT cord-254580-nhpjvgt4 88 2 article article NN cord-254580-nhpjvgt4 88 3 is be VBZ cord-254580-nhpjvgt4 88 4 protected protect VBN cord-254580-nhpjvgt4 88 5 by by IN cord-254580-nhpjvgt4 88 6 copyright copyright NN cord-254580-nhpjvgt4 88 7 . . . cord-254580-nhpjvgt4 89 1 All all DT cord-254580-nhpjvgt4 89 2 rights right NNS cord-254580-nhpjvgt4 89 3 reserved reserve VBN cord-254580-nhpjvgt4 89 4 . . . cord-254580-nhpjvgt4 90 1 Anti Anti NNP cord-254580-nhpjvgt4 90 2 - - NNP cord-254580-nhpjvgt4 90 3 TNF TNF NNP cord-254580-nhpjvgt4 90 4 - - HYPH cord-254580-nhpjvgt4 90 5 α α NNP cord-254580-nhpjvgt4 90 6 therapies therapy NNS cord-254580-nhpjvgt4 90 7 inhibit inhibit VBP cord-254580-nhpjvgt4 90 8 a a DT cord-254580-nhpjvgt4 90 9 crucial crucial JJ cord-254580-nhpjvgt4 90 10 immunological immunological JJ cord-254580-nhpjvgt4 90 11 pathway pathway NN cord-254580-nhpjvgt4 90 12 , , , cord-254580-nhpjvgt4 90 13 therefore therefore RB cord-254580-nhpjvgt4 90 14 an an DT cord-254580-nhpjvgt4 90 15 immunosuppressive immunosuppressive JJ cord-254580-nhpjvgt4 90 16 effect effect NN cord-254580-nhpjvgt4 90 17 and and CC cord-254580-nhpjvgt4 90 18 increased increase VBN cord-254580-nhpjvgt4 90 19 infection infection NN cord-254580-nhpjvgt4 90 20 risk risk NN cord-254580-nhpjvgt4 90 21 are be VBP cord-254580-nhpjvgt4 90 22 expected expect VBN cord-254580-nhpjvgt4 90 23 . . . cord-254580-nhpjvgt4 91 1 There there EX cord-254580-nhpjvgt4 91 2 is be VBZ cord-254580-nhpjvgt4 91 3 an an DT cord-254580-nhpjvgt4 91 4 FDArequired fdarequired JJ cord-254580-nhpjvgt4 91 5 black black JJ cord-254580-nhpjvgt4 91 6 box box NN cord-254580-nhpjvgt4 91 7 warning warning NN cord-254580-nhpjvgt4 91 8 of of IN cord-254580-nhpjvgt4 91 9 infection infection NN cord-254580-nhpjvgt4 91 10 susceptibility susceptibility NN cord-254580-nhpjvgt4 91 11 . . . cord-254580-nhpjvgt4 92 1 29 29 CD cord-254580-nhpjvgt4 93 1 However however RB cord-254580-nhpjvgt4 93 2 , , , cord-254580-nhpjvgt4 93 3 assessing assess VBG cord-254580-nhpjvgt4 93 4 infection infection NN cord-254580-nhpjvgt4 93 5 risk risk NN cord-254580-nhpjvgt4 93 6 is be VBZ cord-254580-nhpjvgt4 93 7 challenging challenging JJ cord-254580-nhpjvgt4 93 8 because because IN cord-254580-nhpjvgt4 93 9 RCTs rct NNS cord-254580-nhpjvgt4 93 10 are be VBP cord-254580-nhpjvgt4 93 11 often often RB cord-254580-nhpjvgt4 93 12 not not RB cord-254580-nhpjvgt4 93 13 adequately adequately RB cord-254580-nhpjvgt4 93 14 powered powered JJ cord-254580-nhpjvgt4 93 15 to to TO cord-254580-nhpjvgt4 93 16 detect detect VB cord-254580-nhpjvgt4 93 17 rare rare JJ cord-254580-nhpjvgt4 93 18 events event NNS cord-254580-nhpjvgt4 93 19 and and CC cord-254580-nhpjvgt4 93 20 ineligibility ineligibility NN cord-254580-nhpjvgt4 93 21 criteria criterion NNS cord-254580-nhpjvgt4 93 22 may may MD cord-254580-nhpjvgt4 93 23 exclude exclude VB cord-254580-nhpjvgt4 93 24 up up IN cord-254580-nhpjvgt4 93 25 to to TO cord-254580-nhpjvgt4 93 26 30 30 CD cord-254580-nhpjvgt4 93 27 % % NN cord-254580-nhpjvgt4 93 28 of of IN cord-254580-nhpjvgt4 93 29 real real JJ cord-254580-nhpjvgt4 93 30 - - HYPH cord-254580-nhpjvgt4 93 31 world world NN cord-254580-nhpjvgt4 93 32 patients patient NNS cord-254580-nhpjvgt4 93 33 . . . cord-254580-nhpjvgt4 94 1 30 30 CD cord-254580-nhpjvgt4 94 2 Certolizumab Certolizumab NNP cord-254580-nhpjvgt4 94 3 increased increase VBD cord-254580-nhpjvgt4 94 4 risks risk NNS cord-254580-nhpjvgt4 94 5 of of IN cord-254580-nhpjvgt4 94 6 all all DT cord-254580-nhpjvgt4 94 7 infections infection NNS cord-254580-nhpjvgt4 94 8 , , , cord-254580-nhpjvgt4 94 9 URIs uri NNS cord-254580-nhpjvgt4 94 10 and and CC cord-254580-nhpjvgt4 94 11 nasopharyngitis nasopharyngitis NN cord-254580-nhpjvgt4 94 12 by by IN cord-254580-nhpjvgt4 94 13 5 5 CD cord-254580-nhpjvgt4 94 14 % % NN cord-254580-nhpjvgt4 94 15 , , , cord-254580-nhpjvgt4 94 16 2 2 CD cord-254580-nhpjvgt4 94 17 % % NN cord-254580-nhpjvgt4 94 18 and and CC cord-254580-nhpjvgt4 94 19 2 2 CD cord-254580-nhpjvgt4 94 20 % % NN cord-254580-nhpjvgt4 94 21 , , , cord-254580-nhpjvgt4 94 22 respectively respectively RB cord-254580-nhpjvgt4 94 23 . . . cord-254580-nhpjvgt4 95 1 29 29 CD cord-254580-nhpjvgt4 96 1 Additionally additionally RB cord-254580-nhpjvgt4 96 2 , , , cord-254580-nhpjvgt4 96 3 anti anti JJ cord-254580-nhpjvgt4 96 4 - - JJ cord-254580-nhpjvgt4 96 5 TNF TNF NNP cord-254580-nhpjvgt4 96 6 - - HYPH cord-254580-nhpjvgt4 96 7 α α NN cord-254580-nhpjvgt4 96 8 therapy therapy NN cord-254580-nhpjvgt4 96 9 is be VBZ cord-254580-nhpjvgt4 96 10 associated associate VBN cord-254580-nhpjvgt4 96 11 with with IN cord-254580-nhpjvgt4 96 12 latent latent JJ cord-254580-nhpjvgt4 96 13 tuberculosis tuberculosis NN cord-254580-nhpjvgt4 96 14 reactivation reactivation NN cord-254580-nhpjvgt4 96 15 , , , cord-254580-nhpjvgt4 96 16 even even RB cord-254580-nhpjvgt4 96 17 with with IN cord-254580-nhpjvgt4 96 18 chemoprophylaxis chemoprophylaxis NNP cord-254580-nhpjvgt4 96 19 ; ; : cord-254580-nhpjvgt4 96 20 infliximab infliximab NNP cord-254580-nhpjvgt4 96 21 is be VBZ cord-254580-nhpjvgt4 96 22 associated associate VBN cord-254580-nhpjvgt4 96 23 with with IN cord-254580-nhpjvgt4 96 24 increased increase VBN cord-254580-nhpjvgt4 96 25 risk risk NN cord-254580-nhpjvgt4 96 26 of of IN cord-254580-nhpjvgt4 96 27 herpes herpes NNP cord-254580-nhpjvgt4 96 28 zoster zoster NNP cord-254580-nhpjvgt4 96 29 . . . cord-254580-nhpjvgt4 97 1 34 34 CD cord-254580-nhpjvgt4 97 2 , , , cord-254580-nhpjvgt4 97 3 35 35 CD cord-254580-nhpjvgt4 97 4 Therefore therefore RB cord-254580-nhpjvgt4 97 5 , , , cord-254580-nhpjvgt4 97 6 based base VBN cord-254580-nhpjvgt4 97 7 on on IN cord-254580-nhpjvgt4 97 8 available available JJ cord-254580-nhpjvgt4 97 9 data datum NNS cord-254580-nhpjvgt4 97 10 , , , cord-254580-nhpjvgt4 97 11 anti anti JJ cord-254580-nhpjvgt4 97 12 - - JJ cord-254580-nhpjvgt4 97 13 TNF TNF NNP cord-254580-nhpjvgt4 97 14 - - HYPH cord-254580-nhpjvgt4 97 15 α α NNP cord-254580-nhpjvgt4 97 16 biologics biologic NNS cord-254580-nhpjvgt4 97 17 should should MD cord-254580-nhpjvgt4 97 18 be be VB cord-254580-nhpjvgt4 97 19 held hold VBN cord-254580-nhpjvgt4 97 20 Similarly similarly RB cord-254580-nhpjvgt4 97 21 , , , cord-254580-nhpjvgt4 97 22 an an DT cord-254580-nhpjvgt4 97 23 11 11 CD cord-254580-nhpjvgt4 97 24 % % NN cord-254580-nhpjvgt4 97 25 increased increase VBN cord-254580-nhpjvgt4 97 26 risk risk NN cord-254580-nhpjvgt4 97 27 in in IN cord-254580-nhpjvgt4 97 28 overall overall JJ cord-254580-nhpjvgt4 97 29 infections infection NNS cord-254580-nhpjvgt4 97 30 with with IN cord-254580-nhpjvgt4 97 31 secukinumab secukinumab NNS cord-254580-nhpjvgt4 97 32 was be VBD cord-254580-nhpjvgt4 97 33 reported report VBN cord-254580-nhpjvgt4 97 34 based base VBN cord-254580-nhpjvgt4 97 35 on on IN cord-254580-nhpjvgt4 97 36 pivotal pivotal JJ cord-254580-nhpjvgt4 97 37 trials trial NNS cord-254580-nhpjvgt4 97 38 , , , cord-254580-nhpjvgt4 97 39 with with IN cord-254580-nhpjvgt4 97 40 most most RBS cord-254580-nhpjvgt4 97 41 attributable attributable JJ cord-254580-nhpjvgt4 97 42 to to IN cord-254580-nhpjvgt4 97 43 yeast yeast NN cord-254580-nhpjvgt4 97 44 infections infection NNS cord-254580-nhpjvgt4 97 45 ; ; : cord-254580-nhpjvgt4 97 46 URIs uri NNS cord-254580-nhpjvgt4 97 47 were be VBD cord-254580-nhpjvgt4 97 48 increased increase VBN cord-254580-nhpjvgt4 97 49 slightly slightly RB cord-254580-nhpjvgt4 97 50 for for IN cord-254580-nhpjvgt4 97 51 secukinumab secukinumab NNS cord-254580-nhpjvgt4 97 52 , , , cord-254580-nhpjvgt4 97 53 but but CC cord-254580-nhpjvgt4 97 54 not not RB cord-254580-nhpjvgt4 97 55 for for IN cord-254580-nhpjvgt4 97 56 ixekizumab ixekizumab NNP cord-254580-nhpjvgt4 97 57 or or CC cord-254580-nhpjvgt4 97 58 brodalumab brodalumab NNP cord-254580-nhpjvgt4 97 59 . . . cord-254580-nhpjvgt4 98 1 29 29 CD cord-254580-nhpjvgt4 99 1 Since since IN cord-254580-nhpjvgt4 99 2 IL-17 IL-17 NNP cord-254580-nhpjvgt4 99 3 plays play VBZ cord-254580-nhpjvgt4 99 4 an an DT cord-254580-nhpjvgt4 99 5 important important JJ cord-254580-nhpjvgt4 99 6 role role NN cord-254580-nhpjvgt4 99 7 in in IN cord-254580-nhpjvgt4 99 8 immunological immunological JJ cord-254580-nhpjvgt4 99 9 response response NN cord-254580-nhpjvgt4 99 10 against against IN cord-254580-nhpjvgt4 99 11 candida candida NN cord-254580-nhpjvgt4 99 12 infections infection NNS cord-254580-nhpjvgt4 99 13 , , , cord-254580-nhpjvgt4 99 14 there there EX cord-254580-nhpjvgt4 99 15 is be VBZ cord-254580-nhpjvgt4 99 16 a a DT cord-254580-nhpjvgt4 99 17 theoretical theoretical JJ cord-254580-nhpjvgt4 99 18 increased increase VBN cord-254580-nhpjvgt4 99 19 risk risk NN cord-254580-nhpjvgt4 99 20 of of IN cord-254580-nhpjvgt4 99 21 yeast yeast NN cord-254580-nhpjvgt4 99 22 infections infection NNS cord-254580-nhpjvgt4 99 23 with with IN cord-254580-nhpjvgt4 99 24 anti anti JJ cord-254580-nhpjvgt4 99 25 - - JJ cord-254580-nhpjvgt4 99 26 IL17 il17 JJ cord-254580-nhpjvgt4 99 27 therapies therapy NNS cord-254580-nhpjvgt4 99 28 . . . cord-254580-nhpjvgt4 100 1 40 40 CD cord-254580-nhpjvgt4 101 1 In in IN cord-254580-nhpjvgt4 101 2 a a DT cord-254580-nhpjvgt4 101 3 pooled pool VBN cord-254580-nhpjvgt4 101 4 analysis analysis NN cord-254580-nhpjvgt4 101 5 from from IN cord-254580-nhpjvgt4 101 6 10 10 CD cord-254580-nhpjvgt4 101 7 phase phase NN cord-254580-nhpjvgt4 101 8 two two CD cord-254580-nhpjvgt4 101 9 and and CC cord-254580-nhpjvgt4 101 10 three three CD cord-254580-nhpjvgt4 101 11 clinical clinical JJ cord-254580-nhpjvgt4 101 12 studies study NNS cord-254580-nhpjvgt4 101 13 on on IN cord-254580-nhpjvgt4 101 14 3,430 3,430 CD cord-254580-nhpjvgt4 101 15 psoriasis psoriasis NN cord-254580-nhpjvgt4 101 16 patients patient NNS cord-254580-nhpjvgt4 101 17 treated treat VBN cord-254580-nhpjvgt4 101 18 with with IN cord-254580-nhpjvgt4 101 19 secukinumab secukinumab NNP cord-254580-nhpjvgt4 101 20 300 300 CD cord-254580-nhpjvgt4 101 21 mg mg NNP cord-254580-nhpjvgt4 101 22 ( ( -LRB- cord-254580-nhpjvgt4 101 23 n=1,1410 n=1,1410 NNP cord-254580-nhpjvgt4 101 24 ) ) -RRB- cord-254580-nhpjvgt4 101 25 , , , cord-254580-nhpjvgt4 101 26 150 150 CD cord-254580-nhpjvgt4 101 27 mg mg NN cord-254580-nhpjvgt4 101 28 ( ( -LRB- cord-254580-nhpjvgt4 101 29 n=1,395 n=1,395 NNP cord-254580-nhpjvgt4 101 30 ) ) -RRB- cord-254580-nhpjvgt4 101 31 and and CC cord-254580-nhpjvgt4 101 32 etanercept etanercept NNP cord-254580-nhpjvgt4 101 33 ( ( -LRB- cord-254580-nhpjvgt4 101 34 n=323 n=323 NNP cord-254580-nhpjvgt4 101 35 ) ) -RRB- cord-254580-nhpjvgt4 102 1 , , , cord-254580-nhpjvgt4 102 2 candida candida NN cord-254580-nhpjvgt4 102 3 infections infection NNS cord-254580-nhpjvgt4 102 4 were be VBD cord-254580-nhpjvgt4 102 5 reported report VBN cord-254580-nhpjvgt4 102 6 in in IN cord-254580-nhpjvgt4 102 7 2.9 2.9 CD cord-254580-nhpjvgt4 102 8 % % NN cord-254580-nhpjvgt4 102 9 , , , cord-254580-nhpjvgt4 102 10 1.5 1.5 CD cord-254580-nhpjvgt4 102 11 % % NN cord-254580-nhpjvgt4 102 12 and and CC cord-254580-nhpjvgt4 102 13 1.2 1.2 CD cord-254580-nhpjvgt4 102 14 % % NN cord-254580-nhpjvgt4 102 15 of of IN cord-254580-nhpjvgt4 102 16 subjects subject NNS cord-254580-nhpjvgt4 102 17 , , , cord-254580-nhpjvgt4 102 18 respectively respectively RB cord-254580-nhpjvgt4 102 19 . . . cord-254580-nhpjvgt4 103 1 41 41 CD cord-254580-nhpjvgt4 104 1 All all DT cord-254580-nhpjvgt4 104 2 infections infection NNS cord-254580-nhpjvgt4 104 3 were be VBD cord-254580-nhpjvgt4 104 4 mild mild JJ cord-254580-nhpjvgt4 104 5 , , , cord-254580-nhpjvgt4 104 6 resolved resolve VBN cord-254580-nhpjvgt4 104 7 spontaneously spontaneously RB cord-254580-nhpjvgt4 104 8 or or CC cord-254580-nhpjvgt4 104 9 responded respond VBD cord-254580-nhpjvgt4 104 10 to to IN cord-254580-nhpjvgt4 104 11 standard standard JJ cord-254580-nhpjvgt4 104 12 treatment treatment NN cord-254580-nhpjvgt4 104 13 , , , cord-254580-nhpjvgt4 104 14 without without IN cord-254580-nhpjvgt4 104 15 causing cause VBG cord-254580-nhpjvgt4 104 16 treatment treatment NN cord-254580-nhpjvgt4 104 17 discontinuation discontinuation NN cord-254580-nhpjvgt4 104 18 . . . cord-254580-nhpjvgt4 105 1 41 41 CD cord-254580-nhpjvgt4 105 2 Overall Overall NNP cord-254580-nhpjvgt4 105 3 , , , cord-254580-nhpjvgt4 105 4 increased increase VBN cord-254580-nhpjvgt4 105 5 infection infection NN cord-254580-nhpjvgt4 105 6 risk risk NN cord-254580-nhpjvgt4 105 7 has have VBZ cord-254580-nhpjvgt4 105 8 been be VBN cord-254580-nhpjvgt4 105 9 shown show VBN cord-254580-nhpjvgt4 105 10 with with IN cord-254580-nhpjvgt4 105 11 IL-17 IL-17 NNP cord-254580-nhpjvgt4 105 12 inhibitors inhibitor NNS cord-254580-nhpjvgt4 105 13 , , , cord-254580-nhpjvgt4 105 14 but but CC cord-254580-nhpjvgt4 105 15 yeast yeast NN cord-254580-nhpjvgt4 105 16 infections infection NNS cord-254580-nhpjvgt4 105 17 may may MD cord-254580-nhpjvgt4 105 18 constitute constitute VB cord-254580-nhpjvgt4 105 19 a a DT cord-254580-nhpjvgt4 105 20 large large JJ cord-254580-nhpjvgt4 105 21 proportion proportion NN cord-254580-nhpjvgt4 105 22 of of IN cord-254580-nhpjvgt4 105 23 that that DT cord-254580-nhpjvgt4 105 24 increase increase NN cord-254580-nhpjvgt4 105 25 ; ; : cord-254580-nhpjvgt4 105 26 URIs uri NNS cord-254580-nhpjvgt4 105 27 are be VBP cord-254580-nhpjvgt4 105 28 particularly particularly RB cord-254580-nhpjvgt4 105 29 uncommon uncommon JJ cord-254580-nhpjvgt4 105 30 . . . cord-254580-nhpjvgt4 106 1 Therefore therefore RB cord-254580-nhpjvgt4 106 2 , , , cord-254580-nhpjvgt4 106 3 IL-17 IL-17 NNP cord-254580-nhpjvgt4 106 4 inhibitors inhibitor NNS cord-254580-nhpjvgt4 106 5 may may MD cord-254580-nhpjvgt4 106 6 be be VB cord-254580-nhpjvgt4 106 7 safely safely RB cord-254580-nhpjvgt4 106 8 prescribed prescribe VBN cord-254580-nhpjvgt4 106 9 and and CC cord-254580-nhpjvgt4 106 10 continued continue VBD cord-254580-nhpjvgt4 106 11 , , , cord-254580-nhpjvgt4 106 12 unless unless IN cord-254580-nhpjvgt4 106 13 the the DT cord-254580-nhpjvgt4 106 14 patient patient NN cord-254580-nhpjvgt4 106 15 is be VBZ cord-254580-nhpjvgt4 106 16 symptomatic symptomatic JJ cord-254580-nhpjvgt4 106 17 or or CC cord-254580-nhpjvgt4 106 18 positive positive JJ cord-254580-nhpjvgt4 106 19 for for IN cord-254580-nhpjvgt4 106 20 SARS SARS NNP cord-254580-nhpjvgt4 106 21 - - HYPH cord-254580-nhpjvgt4 106 22 CoV-2 CoV-2 NNP cord-254580-nhpjvgt4 106 23 . . . cord-254580-nhpjvgt4 107 1 Ustekinumab Ustekinumab NNP cord-254580-nhpjvgt4 107 2 inhibits inhibit VBZ cord-254580-nhpjvgt4 107 3 IL-12 IL-12 NNP cord-254580-nhpjvgt4 107 4 and and CC cord-254580-nhpjvgt4 107 5 IL-23 IL-23 NNP cord-254580-nhpjvgt4 107 6 , , , cord-254580-nhpjvgt4 107 7 with with IN cord-254580-nhpjvgt4 107 8 IL-12 IL-12 NNP cord-254580-nhpjvgt4 107 9 playing play VBG cord-254580-nhpjvgt4 107 10 an an DT cord-254580-nhpjvgt4 107 11 important important JJ cord-254580-nhpjvgt4 107 12 role role NN cord-254580-nhpjvgt4 107 13 in in IN cord-254580-nhpjvgt4 107 14 protection protection NN cord-254580-nhpjvgt4 107 15 against against IN cord-254580-nhpjvgt4 107 16 viral viral JJ cord-254580-nhpjvgt4 107 17 infections infection NNS cord-254580-nhpjvgt4 107 18 . . . cord-254580-nhpjvgt4 108 1 29 29 CD cord-254580-nhpjvgt4 108 2 , , , cord-254580-nhpjvgt4 108 3 42 42 CD cord-254580-nhpjvgt4 108 4 , , , cord-254580-nhpjvgt4 108 5 43 43 CD cord-254580-nhpjvgt4 109 1 However however RB cord-254580-nhpjvgt4 109 2 , , , cord-254580-nhpjvgt4 109 3 no no DT cord-254580-nhpjvgt4 109 4 increased increase VBN cord-254580-nhpjvgt4 109 5 susceptibility susceptibility NN cord-254580-nhpjvgt4 109 6 to to IN cord-254580-nhpjvgt4 109 7 infection infection NN cord-254580-nhpjvgt4 109 8 with with IN cord-254580-nhpjvgt4 109 9 ustekinumab ustekinumab NN cord-254580-nhpjvgt4 109 10 has have VBZ cord-254580-nhpjvgt4 109 11 been be VBN cord-254580-nhpjvgt4 109 12 reported report VBN cord-254580-nhpjvgt4 109 13 . . . cord-254580-nhpjvgt4 110 1 In in IN cord-254580-nhpjvgt4 110 2 a a DT cord-254580-nhpjvgt4 110 3 pooled pool VBN cord-254580-nhpjvgt4 110 4 analysis analysis NN cord-254580-nhpjvgt4 110 5 of of IN cord-254580-nhpjvgt4 110 6 four four CD cord-254580-nhpjvgt4 110 7 phase phase NN cord-254580-nhpjvgt4 110 8 two two CD cord-254580-nhpjvgt4 110 9 / / SYM cord-254580-nhpjvgt4 110 10 three three CD cord-254580-nhpjvgt4 110 11 studies study NNS cord-254580-nhpjvgt4 110 12 of of IN cord-254580-nhpjvgt4 110 13 3 3 CD cord-254580-nhpjvgt4 110 14 , , , cord-254580-nhpjvgt4 110 15 117 117 CD cord-254580-nhpjvgt4 110 16 This this DT cord-254580-nhpjvgt4 110 17 article article NN cord-254580-nhpjvgt4 110 18 is be VBZ cord-254580-nhpjvgt4 110 19 protected protect VBN cord-254580-nhpjvgt4 110 20 by by IN cord-254580-nhpjvgt4 110 21 copyright copyright NN cord-254580-nhpjvgt4 110 22 . . . cord-254580-nhpjvgt4 111 1 All all DT cord-254580-nhpjvgt4 111 2 rights right NNS cord-254580-nhpjvgt4 111 3 reserved reserve VBN cord-254580-nhpjvgt4 111 4 . . . cord-254580-nhpjvgt4 111 5 _SP cord-254580-nhpjvgt4 112 1 Contrary contrary JJ cord-254580-nhpjvgt4 112 2 to to IN cord-254580-nhpjvgt4 112 3 IL-12/23 il-12/23 NN cord-254580-nhpjvgt4 112 4 inhibitors inhibitor NNS cord-254580-nhpjvgt4 112 5 , , , cord-254580-nhpjvgt4 113 1 anti anti JJ cord-254580-nhpjvgt4 113 2 - - JJ cord-254580-nhpjvgt4 113 3 IL-23 IL-23 NNP cord-254580-nhpjvgt4 113 4 therapies therapy NNS cord-254580-nhpjvgt4 113 5 do do VBP cord-254580-nhpjvgt4 113 6 not not RB cord-254580-nhpjvgt4 113 7 target target VB cord-254580-nhpjvgt4 113 8 IL-12 IL-12 NNP cord-254580-nhpjvgt4 113 9 , , , cord-254580-nhpjvgt4 113 10 and and CC cord-254580-nhpjvgt4 113 11 IL-12 IL-12 NNP cord-254580-nhpjvgt4 113 12 plays play VBZ cord-254580-nhpjvgt4 113 13 a a DT cord-254580-nhpjvgt4 113 14 key key JJ cord-254580-nhpjvgt4 113 15 role role NN cord-254580-nhpjvgt4 113 16 fighting fight VBG cord-254580-nhpjvgt4 113 17 viral viral JJ cord-254580-nhpjvgt4 113 18 infections infection NNS cord-254580-nhpjvgt4 113 19 . . . cord-254580-nhpjvgt4 114 1 29 29 CD cord-254580-nhpjvgt4 114 2 , , , cord-254580-nhpjvgt4 114 3 45 45 CD cord-254580-nhpjvgt4 114 4 Reduced reduce VBN cord-254580-nhpjvgt4 114 5 risks risk NNS cord-254580-nhpjvgt4 114 6 of of IN cord-254580-nhpjvgt4 114 7 salmonella salmonella NN cord-254580-nhpjvgt4 114 8 , , , cord-254580-nhpjvgt4 114 9 candida candida NN cord-254580-nhpjvgt4 114 10 and and CC cord-254580-nhpjvgt4 114 11 mycobacterium mycobacterium NN cord-254580-nhpjvgt4 114 12 infections infection NNS cord-254580-nhpjvgt4 114 13 were be VBD cord-254580-nhpjvgt4 114 14 seen see VBN cord-254580-nhpjvgt4 114 15 in in IN cord-254580-nhpjvgt4 114 16 IL-23p19-targeted IL-23p19-targeted NNP cord-254580-nhpjvgt4 114 17 vs. vs. FW cord-254580-nhpjvgt4 114 18 IL-12/23p40-targeted IL-12/23p40-targeted NNP cord-254580-nhpjvgt4 114 19 animal animal NN cord-254580-nhpjvgt4 114 20 models model NNS cord-254580-nhpjvgt4 114 21 . . . cord-254580-nhpjvgt4 115 1 46 46 CD cord-254580-nhpjvgt4 115 2 - - SYM cord-254580-nhpjvgt4 115 3 49 49 CD cord-254580-nhpjvgt4 116 1 Nonetheless nonetheless RB cord-254580-nhpjvgt4 116 2 , , , cord-254580-nhpjvgt4 116 3 RCTs RCTs NNPS cord-254580-nhpjvgt4 116 4 on on IN cord-254580-nhpjvgt4 116 5 IL-23 IL-23 NNP cord-254580-nhpjvgt4 116 6 inhibitors inhibitor NNS cord-254580-nhpjvgt4 116 7 have have VBP cord-254580-nhpjvgt4 116 8 shown show VBN cord-254580-nhpjvgt4 116 9 conflicting conflict VBG cord-254580-nhpjvgt4 116 10 results result NNS cord-254580-nhpjvgt4 116 11 regarding regard VBG cord-254580-nhpjvgt4 116 12 infection infection NN cord-254580-nhpjvgt4 116 13 risks risk NNS cord-254580-nhpjvgt4 116 14 . . . cord-254580-nhpjvgt4 117 1 In in IN cord-254580-nhpjvgt4 117 2 a a DT cord-254580-nhpjvgt4 117 3 phase phase NN cord-254580-nhpjvgt4 117 4 III iii CD cord-254580-nhpjvgt4 117 5 , , , cord-254580-nhpjvgt4 117 6 double double RB cord-254580-nhpjvgt4 117 7 - - HYPH cord-254580-nhpjvgt4 117 8 blinded blinded JJ cord-254580-nhpjvgt4 117 9 , , , cord-254580-nhpjvgt4 117 10 placebo placebo NN cord-254580-nhpjvgt4 117 11 - - HYPH cord-254580-nhpjvgt4 117 12 controlled control VBN cord-254580-nhpjvgt4 117 13 study study NN cord-254580-nhpjvgt4 117 14 on on IN cord-254580-nhpjvgt4 117 15 837 837 CD cord-254580-nhpjvgt4 117 16 psoriasis psoriasis NN cord-254580-nhpjvgt4 117 17 patients patient NNS cord-254580-nhpjvgt4 117 18 randomized randomize VBN cord-254580-nhpjvgt4 117 19 to to IN cord-254580-nhpjvgt4 117 20 treatment treatment NN cord-254580-nhpjvgt4 117 21 with with IN cord-254580-nhpjvgt4 117 22 guselkumab guselkumab NNS cord-254580-nhpjvgt4 117 23 , , , cord-254580-nhpjvgt4 117 24 adalimumab adalimumab NNS cord-254580-nhpjvgt4 117 25 or or CC cord-254580-nhpjvgt4 117 26 placebo placebo NN cord-254580-nhpjvgt4 117 27 , , , cord-254580-nhpjvgt4 117 28 overall overall RB cord-254580-nhpjvgt4 117 29 , , , cord-254580-nhpjvgt4 117 30 candida candida NN cord-254580-nhpjvgt4 117 31 , , , cord-254580-nhpjvgt4 117 32 and and CC cord-254580-nhpjvgt4 117 33 serious serious JJ cord-254580-nhpjvgt4 117 34 infections infection NNS cord-254580-nhpjvgt4 117 35 , , , cord-254580-nhpjvgt4 117 36 occurred occur VBD cord-254580-nhpjvgt4 117 37 at at IN cord-254580-nhpjvgt4 117 38 comparable comparable JJ cord-254580-nhpjvgt4 117 39 rates rate NNS cord-254580-nhpjvgt4 117 40 across across IN cord-254580-nhpjvgt4 117 41 treatment treatment NN cord-254580-nhpjvgt4 117 42 groups group NNS cord-254580-nhpjvgt4 117 43 . . . cord-254580-nhpjvgt4 118 1 50 50 CD cord-254580-nhpjvgt4 119 1 In in IN cord-254580-nhpjvgt4 119 2 798 798 CD cord-254580-nhpjvgt4 119 3 risankizumab risankizumab NNS cord-254580-nhpjvgt4 119 4 - - HYPH cord-254580-nhpjvgt4 119 5 treated treat VBN cord-254580-nhpjvgt4 119 6 psoriasis psoriasis NN cord-254580-nhpjvgt4 119 7 patients patient NNS cord-254580-nhpjvgt4 119 8 , , , cord-254580-nhpjvgt4 119 9 there there EX cord-254580-nhpjvgt4 119 10 was be VBD cord-254580-nhpjvgt4 119 11 increased increase VBN cord-254580-nhpjvgt4 120 1 overall overall JJ cord-254580-nhpjvgt4 120 2 infection infection NN cord-254580-nhpjvgt4 120 3 risk risk NN cord-254580-nhpjvgt4 120 4 in in IN cord-254580-nhpjvgt4 120 5 two two CD cord-254580-nhpjvgt4 120 6 This this DT cord-254580-nhpjvgt4 120 7 article article NN cord-254580-nhpjvgt4 120 8 is be VBZ cord-254580-nhpjvgt4 120 9 protected protect VBN cord-254580-nhpjvgt4 120 10 by by IN cord-254580-nhpjvgt4 120 11 copyright copyright NN cord-254580-nhpjvgt4 120 12 . . . cord-254580-nhpjvgt4 121 1 All all DT cord-254580-nhpjvgt4 121 2 rights right NNS cord-254580-nhpjvgt4 121 3 reserved reserve VBN cord-254580-nhpjvgt4 121 4 . . . cord-254580-nhpjvgt4 122 1 phase phase NN cord-254580-nhpjvgt4 122 2 three three CD cord-254580-nhpjvgt4 122 3 studies study NNS cord-254580-nhpjvgt4 122 4 . . . cord-254580-nhpjvgt4 123 1 51 51 CD cord-254580-nhpjvgt4 124 1 The the DT cord-254580-nhpjvgt4 124 2 most most RBS cord-254580-nhpjvgt4 124 3 common common JJ cord-254580-nhpjvgt4 124 4 infections infection NNS cord-254580-nhpjvgt4 124 5 were be VBD cord-254580-nhpjvgt4 124 6 URIs uri NNS cord-254580-nhpjvgt4 124 7 , , , cord-254580-nhpjvgt4 124 8 urinary urinary JJ cord-254580-nhpjvgt4 124 9 tract tract JJ cord-254580-nhpjvgt4 124 10 infections infection NNS cord-254580-nhpjvgt4 124 11 and and CC cord-254580-nhpjvgt4 124 12 influenza influenza NN cord-254580-nhpjvgt4 124 13 . . . cord-254580-nhpjvgt4 125 1 51 51 CD cord-254580-nhpjvgt4 126 1 Two two CD cord-254580-nhpjvgt4 126 2 cases case NNS cord-254580-nhpjvgt4 126 3 of of IN cord-254580-nhpjvgt4 126 4 latent latent JJ cord-254580-nhpjvgt4 126 5 tuberculosis tuberculosis NN cord-254580-nhpjvgt4 126 6 were be VBD cord-254580-nhpjvgt4 126 7 reported report VBN cord-254580-nhpjvgt4 126 8 in in IN cord-254580-nhpjvgt4 126 9 the the DT cord-254580-nhpjvgt4 126 10 risankizumab risankizumab NNP cord-254580-nhpjvgt4 126 11 group group NN cord-254580-nhpjvgt4 126 12 ; ; : cord-254580-nhpjvgt4 126 13 both both DT cord-254580-nhpjvgt4 126 14 patients patient NNS cord-254580-nhpjvgt4 126 15 tested test VBD cord-254580-nhpjvgt4 126 16 negative negative JJ cord-254580-nhpjvgt4 126 17 at at IN cord-254580-nhpjvgt4 126 18 baseline baseline NN cord-254580-nhpjvgt4 126 19 . . . cord-254580-nhpjvgt4 127 1 51 51 CD cord-254580-nhpjvgt4 128 1 Data datum NNS cord-254580-nhpjvgt4 128 2 assessing assess VBG cord-254580-nhpjvgt4 128 3 infection infection NN cord-254580-nhpjvgt4 128 4 risk risk NN cord-254580-nhpjvgt4 128 5 with with IN cord-254580-nhpjvgt4 128 6 tildrakizumab tildrakizumab NNP cord-254580-nhpjvgt4 128 7 is be VBZ cord-254580-nhpjvgt4 128 8 sparse sparse JJ cord-254580-nhpjvgt4 128 9 . . . cord-254580-nhpjvgt4 129 1 Lebwohl Lebwohl NNP cord-254580-nhpjvgt4 129 2 et et FW cord-254580-nhpjvgt4 129 3 al al NNP cord-254580-nhpjvgt4 129 4 reported report VBD cord-254580-nhpjvgt4 129 5 an an DT cord-254580-nhpjvgt4 129 6 increase increase NN cord-254580-nhpjvgt4 129 7 in in IN cord-254580-nhpjvgt4 129 8 nasopharyngitis nasopharyngitis NNP cord-254580-nhpjvgt4 129 9 ( ( -LRB- cord-254580-nhpjvgt4 129 10 4 4 CD cord-254580-nhpjvgt4 129 11 % % NN cord-254580-nhpjvgt4 129 12 ) ) -RRB- cord-254580-nhpjvgt4 129 13 with with IN cord-254580-nhpjvgt4 129 14 tildrakizumab tildrakizumab NNS cord-254580-nhpjvgt4 129 15 compared compare VBN cord-254580-nhpjvgt4 129 16 with with IN cord-254580-nhpjvgt4 129 17 placebo placebo NN cord-254580-nhpjvgt4 129 18 . . . cord-254580-nhpjvgt4 130 1 29 29 CD cord-254580-nhpjvgt4 130 2 Risk risk NN cord-254580-nhpjvgt4 130 3 , , , cord-254580-nhpjvgt4 130 4 however however RB cord-254580-nhpjvgt4 130 5 , , , cord-254580-nhpjvgt4 130 6 is be VBZ cord-254580-nhpjvgt4 130 7 low low JJ cord-254580-nhpjvgt4 130 8 and and CC cord-254580-nhpjvgt4 130 9 comparable comparable JJ cord-254580-nhpjvgt4 130 10 to to IN cord-254580-nhpjvgt4 130 11 placebo placebo NN cord-254580-nhpjvgt4 130 12 . . . cord-254580-nhpjvgt4 131 1 Therefore therefore RB cord-254580-nhpjvgt4 131 2 , , , cord-254580-nhpjvgt4 131 3 based base VBN cord-254580-nhpjvgt4 131 4 on on IN cord-254580-nhpjvgt4 131 5 available available JJ cord-254580-nhpjvgt4 131 6 data datum NNS cord-254580-nhpjvgt4 131 7 , , , cord-254580-nhpjvgt4 131 8 IL-23 IL-23 NNP cord-254580-nhpjvgt4 131 9 inhibitors inhibitor NNS cord-254580-nhpjvgt4 131 10 may may MD cord-254580-nhpjvgt4 131 11 be be VB cord-254580-nhpjvgt4 131 12 continued continue VBN cord-254580-nhpjvgt4 131 13 / / SYM cord-254580-nhpjvgt4 131 14 initiated initiate VBN cord-254580-nhpjvgt4 131 15 , , , cord-254580-nhpjvgt4 131 16 unless unless IN cord-254580-nhpjvgt4 131 17 the the DT cord-254580-nhpjvgt4 131 18 patient patient NN cord-254580-nhpjvgt4 131 19 is be VBZ cord-254580-nhpjvgt4 131 20 symptomatic symptomatic JJ cord-254580-nhpjvgt4 131 21 or or CC cord-254580-nhpjvgt4 131 22 positive positive JJ cord-254580-nhpjvgt4 131 23 for for IN cord-254580-nhpjvgt4 131 24 SARS SARS NNP cord-254580-nhpjvgt4 131 25 - - HYPH cord-254580-nhpjvgt4 131 26 CoV-2 CoV-2 NNP cord-254580-nhpjvgt4 131 27 . . . cord-254580-nhpjvgt4 132 1 Tofacitinib Tofacitinib NNP cord-254580-nhpjvgt4 132 2 is be VBZ cord-254580-nhpjvgt4 132 3 a a DT cord-254580-nhpjvgt4 132 4 small small JJ cord-254580-nhpjvgt4 132 5 molecule molecule NN cord-254580-nhpjvgt4 132 6 inhibitor inhibitor NN cord-254580-nhpjvgt4 132 7 of of IN cord-254580-nhpjvgt4 132 8 tyrosine tyrosine NN cord-254580-nhpjvgt4 132 9 kinases kinase NNS cord-254580-nhpjvgt4 132 10 of of IN cord-254580-nhpjvgt4 132 11 the the DT cord-254580-nhpjvgt4 132 12 Janus Janus NNP cord-254580-nhpjvgt4 132 13 family family NN cord-254580-nhpjvgt4 132 14 , , , cord-254580-nhpjvgt4 132 15 preferentially preferentially RB cord-254580-nhpjvgt4 132 16 JAK1 JAK1 NNP cord-254580-nhpjvgt4 132 17 and and CC cord-254580-nhpjvgt4 132 18 JAK3 JAK3 NNP cord-254580-nhpjvgt4 132 19 , , , cord-254580-nhpjvgt4 132 20 downregulating downregulate VBG cord-254580-nhpjvgt4 132 21 cytokines cytokine NNS cord-254580-nhpjvgt4 132 22 crucial crucial JJ cord-254580-nhpjvgt4 132 23 for for IN cord-254580-nhpjvgt4 132 24 lymphocyte lymphocyte NN cord-254580-nhpjvgt4 132 25 development development NN cord-254580-nhpjvgt4 132 26 ; ; : cord-254580-nhpjvgt4 132 27 therefore therefore RB cord-254580-nhpjvgt4 132 28 , , , cord-254580-nhpjvgt4 132 29 there there EX cord-254580-nhpjvgt4 132 30 is be VBZ cord-254580-nhpjvgt4 132 31 potential potential JJ cord-254580-nhpjvgt4 132 32 for for IN cord-254580-nhpjvgt4 132 33 increased increase VBN cord-254580-nhpjvgt4 132 34 risks risk NNS cord-254580-nhpjvgt4 132 35 of of IN cord-254580-nhpjvgt4 132 36 intracellular intracellular JJ cord-254580-nhpjvgt4 132 37 bacterial bacterial JJ cord-254580-nhpjvgt4 132 38 and and CC cord-254580-nhpjvgt4 132 39 viral viral JJ cord-254580-nhpjvgt4 132 40 infections infection NNS cord-254580-nhpjvgt4 132 41 . . . cord-254580-nhpjvgt4 133 1 52 52 CD cord-254580-nhpjvgt4 134 1 It -PRON- PRP cord-254580-nhpjvgt4 134 2 has have VBZ cord-254580-nhpjvgt4 134 3 been be VBN cord-254580-nhpjvgt4 134 4 hypothesized hypothesize VBN cord-254580-nhpjvgt4 134 5 , , , cord-254580-nhpjvgt4 134 6 nonetheless nonetheless RB cord-254580-nhpjvgt4 134 7 , , , cord-254580-nhpjvgt4 134 8 that that IN cord-254580-nhpjvgt4 134 9 fluctuations fluctuation NNS cord-254580-nhpjvgt4 134 10 in in IN cord-254580-nhpjvgt4 134 11 plasma plasma NN cord-254580-nhpjvgt4 134 12 levels level NNS cord-254580-nhpjvgt4 134 13 of of IN cord-254580-nhpjvgt4 134 14 JAK JAK NNP cord-254580-nhpjvgt4 134 15 inhibitors inhibitor NNS cord-254580-nhpjvgt4 134 16 throughout throughout IN cord-254580-nhpjvgt4 134 17 the the DT cord-254580-nhpjvgt4 134 18 day day NN cord-254580-nhpjvgt4 134 19 may may MD cord-254580-nhpjvgt4 134 20 preserve preserve VB cord-254580-nhpjvgt4 134 21 immunogenicity immunogenicity NN cord-254580-nhpjvgt4 134 22 against against IN cord-254580-nhpjvgt4 134 23 infectious infectious JJ cord-254580-nhpjvgt4 134 24 pathogens pathogen NNS cord-254580-nhpjvgt4 134 25 . . . cord-254580-nhpjvgt4 135 1 53 53 CD cord-254580-nhpjvgt4 136 1 Tofacitinib Tofacitinib NNP cord-254580-nhpjvgt4 136 2 carries carry VBZ cord-254580-nhpjvgt4 136 3 an an DT cord-254580-nhpjvgt4 136 4 FDA FDA NNP cord-254580-nhpjvgt4 136 5 - - HYPH cord-254580-nhpjvgt4 136 6 required require VBN cord-254580-nhpjvgt4 136 7 black black JJ cord-254580-nhpjvgt4 136 8 box box NN cord-254580-nhpjvgt4 136 9 warning warn VBG cord-254580-nhpjvgt4 136 10 for for IN cord-254580-nhpjvgt4 136 11 serious serious JJ cord-254580-nhpjvgt4 136 12 infections infection NNS cord-254580-nhpjvgt4 136 13 . . . cord-254580-nhpjvgt4 137 1 In in IN cord-254580-nhpjvgt4 137 2 one one CD cord-254580-nhpjvgt4 137 3 placebo placebo NN cord-254580-nhpjvgt4 137 4 - - HYPH cord-254580-nhpjvgt4 137 5 controlled control VBN cord-254580-nhpjvgt4 137 6 phase phase NN cord-254580-nhpjvgt4 137 7 three three CD cord-254580-nhpjvgt4 137 8 trial trial NN cord-254580-nhpjvgt4 137 9 of of IN cord-254580-nhpjvgt4 137 10 422 422 CD cord-254580-nhpjvgt4 137 11 patients patient NNS cord-254580-nhpjvgt4 137 12 with with IN cord-254580-nhpjvgt4 137 13 psoriatic psoriatic JJ cord-254580-nhpjvgt4 137 14 arthritis arthritis NN cord-254580-nhpjvgt4 137 15 , , , cord-254580-nhpjvgt4 137 16 randomized randomize VBN cord-254580-nhpjvgt4 137 17 to to IN cord-254580-nhpjvgt4 137 18 treatment treatment NN cord-254580-nhpjvgt4 137 19 with with IN cord-254580-nhpjvgt4 137 20 5-mg 5-mg CD cord-254580-nhpjvgt4 137 21 or or CC cord-254580-nhpjvgt4 137 22 10-mg 10-mg CD cord-254580-nhpjvgt4 137 23 tofacitinib tofacitinib NNP cord-254580-nhpjvgt4 137 24 , , , cord-254580-nhpjvgt4 137 25 adalimumab adalimumab NNS cord-254580-nhpjvgt4 137 26 , , , cord-254580-nhpjvgt4 137 27 or or CC cord-254580-nhpjvgt4 137 28 placebo placebo NN cord-254580-nhpjvgt4 137 29 , , , cord-254580-nhpjvgt4 137 30 nasopharyngitis nasopharyngitis NNP cord-254580-nhpjvgt4 137 31 ( ( -LRB- cord-254580-nhpjvgt4 137 32 in in IN cord-254580-nhpjvgt4 137 33 7 7 CD cord-254580-nhpjvgt4 137 34 % % NN cord-254580-nhpjvgt4 137 35 , , , cord-254580-nhpjvgt4 137 36 12 12 CD cord-254580-nhpjvgt4 137 37 % % NN cord-254580-nhpjvgt4 137 38 and and CC cord-254580-nhpjvgt4 137 39 10 10 CD cord-254580-nhpjvgt4 137 40 % % NN cord-254580-nhpjvgt4 137 41 , , , cord-254580-nhpjvgt4 137 42 respectively respectively RB cord-254580-nhpjvgt4 137 43 ) ) -RRB- cord-254580-nhpjvgt4 137 44 and and CC cord-254580-nhpjvgt4 137 45 URIs URIs NNP cord-254580-nhpjvgt4 137 46 ( ( -LRB- cord-254580-nhpjvgt4 137 47 in in IN cord-254580-nhpjvgt4 137 48 9 9 CD cord-254580-nhpjvgt4 137 49 % % NN cord-254580-nhpjvgt4 137 50 , , , cord-254580-nhpjvgt4 137 51 11 11 CD cord-254580-nhpjvgt4 137 52 % % NN cord-254580-nhpjvgt4 137 53 , , , cord-254580-nhpjvgt4 137 54 and and CC cord-254580-nhpjvgt4 137 55 8 8 CD cord-254580-nhpjvgt4 137 56 % % NN cord-254580-nhpjvgt4 137 57 , , , cord-254580-nhpjvgt4 137 58 respectively respectively RB cord-254580-nhpjvgt4 137 59 ) ) -RRB- cord-254580-nhpjvgt4 137 60 were be VBD cord-254580-nhpjvgt4 137 61 the the DT cord-254580-nhpjvgt4 137 62 most most RBS cord-254580-nhpjvgt4 137 63 common common JJ cord-254580-nhpjvgt4 137 64 adverse adverse JJ cord-254580-nhpjvgt4 137 65 events event NNS cord-254580-nhpjvgt4 137 66 . . . cord-254580-nhpjvgt4 138 1 54 54 CD cord-254580-nhpjvgt4 139 1 There there EX cord-254580-nhpjvgt4 139 2 were be VBD cord-254580-nhpjvgt4 139 3 three three CD cord-254580-nhpjvgt4 139 4 cases case NNS cord-254580-nhpjvgt4 139 5 of of IN cord-254580-nhpjvgt4 139 6 serious serious JJ cord-254580-nhpjvgt4 139 7 infections infection NNS cord-254580-nhpjvgt4 139 8 ( ( -LRB- cord-254580-nhpjvgt4 139 9 influenza influenza NN cord-254580-nhpjvgt4 139 10 , , , cord-254580-nhpjvgt4 139 11 appendicitis appendicitis NN cord-254580-nhpjvgt4 139 12 and and CC cord-254580-nhpjvgt4 139 13 pneumonia pneumonia NN cord-254580-nhpjvgt4 139 14 ) ) -RRB- cord-254580-nhpjvgt4 139 15 and and CC cord-254580-nhpjvgt4 139 16 four four CD cord-254580-nhpjvgt4 139 17 cases case NNS cord-254580-nhpjvgt4 139 18 of of IN cord-254580-nhpjvgt4 139 19 herpes herpe NNS cord-254580-nhpjvgt4 139 20 zoster zoster NN cord-254580-nhpjvgt4 139 21 in in IN cord-254580-nhpjvgt4 139 22 the the DT cord-254580-nhpjvgt4 139 23 tofacitinib tofacitinib RB cord-254580-nhpjvgt4 139 24 - - HYPH cord-254580-nhpjvgt4 139 25 treated treat VBN cord-254580-nhpjvgt4 139 26 group group NN cord-254580-nhpjvgt4 139 27 . . . cord-254580-nhpjvgt4 140 1 54 54 CD cord-254580-nhpjvgt4 141 1 Similarly similarly RB cord-254580-nhpjvgt4 141 2 , , , cord-254580-nhpjvgt4 141 3 in in IN cord-254580-nhpjvgt4 141 4 two two CD cord-254580-nhpjvgt4 141 5 randomized randomized JJ cord-254580-nhpjvgt4 141 6 , , , cord-254580-nhpjvgt4 141 7 placebo placebo NN cord-254580-nhpjvgt4 141 8 - - HYPH cord-254580-nhpjvgt4 141 9 controlled control VBN cord-254580-nhpjvgt4 141 10 studies study NNS cord-254580-nhpjvgt4 141 11 of of IN cord-254580-nhpjvgt4 141 12 745 745 CD cord-254580-nhpjvgt4 141 13 and and CC cord-254580-nhpjvgt4 141 14 741 741 CD cord-254580-nhpjvgt4 141 15 psoriasis psoriasis NN cord-254580-nhpjvgt4 141 16 patients patient NNS cord-254580-nhpjvgt4 141 17 treated treat VBN cord-254580-nhpjvgt4 141 18 with with IN cord-254580-nhpjvgt4 141 19 tofacitinib tofacitinib NNP cord-254580-nhpjvgt4 141 20 5-mg 5-mg CD cord-254580-nhpjvgt4 141 21 and and CC cord-254580-nhpjvgt4 141 22 10-mg 10-mg CD cord-254580-nhpjvgt4 141 23 , , , cord-254580-nhpjvgt4 141 24 respectively respectively RB cord-254580-nhpjvgt4 141 25 , , , cord-254580-nhpjvgt4 141 26 nasopharyngitis nasopharyngitis NNP cord-254580-nhpjvgt4 141 27 and and CC cord-254580-nhpjvgt4 141 28 URIs uri NNS cord-254580-nhpjvgt4 141 29 were be VBD cord-254580-nhpjvgt4 141 30 the the DT cord-254580-nhpjvgt4 141 31 most most RBS cord-254580-nhpjvgt4 141 32 common common JJ cord-254580-nhpjvgt4 141 33 infections infection NNS cord-254580-nhpjvgt4 141 34 , , , cord-254580-nhpjvgt4 141 35 and and CC cord-254580-nhpjvgt4 141 36 5 5 CD cord-254580-nhpjvgt4 141 37 serious serious JJ cord-254580-nhpjvgt4 141 38 infections infection NNS cord-254580-nhpjvgt4 141 39 ( ( -LRB- cord-254580-nhpjvgt4 141 40 pneumonia pneumonia NN cord-254580-nhpjvgt4 141 41 , , , cord-254580-nhpjvgt4 141 42 herpes herpes NNP cord-254580-nhpjvgt4 141 43 zoster zoster NN cord-254580-nhpjvgt4 141 44 and and CC cord-254580-nhpjvgt4 141 45 erysipelas erysipela NNS cord-254580-nhpjvgt4 141 46 in in IN cord-254580-nhpjvgt4 141 47 the the DT cord-254580-nhpjvgt4 141 48 5-mg 5-mg CD cord-254580-nhpjvgt4 141 49 group group NN cord-254580-nhpjvgt4 141 50 ; ; : cord-254580-nhpjvgt4 141 51 and and CC cord-254580-nhpjvgt4 141 52 appendicitis appendicitis NN cord-254580-nhpjvgt4 141 53 , , , cord-254580-nhpjvgt4 141 54 pneumonia pneumonia NN cord-254580-nhpjvgt4 141 55 and and CC cord-254580-nhpjvgt4 141 56 pyelonephritis pyelonephritis NN cord-254580-nhpjvgt4 141 57 in in IN cord-254580-nhpjvgt4 141 58 the the DT cord-254580-nhpjvgt4 141 59 10-mg 10-mg CD cord-254580-nhpjvgt4 141 60 group group NN cord-254580-nhpjvgt4 141 61 ) ) -RRB- cord-254580-nhpjvgt4 141 62 were be VBD cord-254580-nhpjvgt4 141 63 reported report VBN cord-254580-nhpjvgt4 141 64 in in IN cord-254580-nhpjvgt4 141 65 tofacitinib tofacitinib RB cord-254580-nhpjvgt4 141 66 - - HYPH cord-254580-nhpjvgt4 141 67 treated treat VBN cord-254580-nhpjvgt4 141 68 patients patient NNS cord-254580-nhpjvgt4 141 69 . . . cord-254580-nhpjvgt4 142 1 55 55 CD cord-254580-nhpjvgt4 143 1 Furthermore furthermore RB cord-254580-nhpjvgt4 143 2 , , , cord-254580-nhpjvgt4 143 3 herpes herpes NN cord-254580-nhpjvgt4 143 4 zoster zoster NN cord-254580-nhpjvgt4 143 5 was be VBD cord-254580-nhpjvgt4 143 6 reported report VBN cord-254580-nhpjvgt4 143 7 in in IN cord-254580-nhpjvgt4 143 8 12 12 CD cord-254580-nhpjvgt4 143 9 tofacitinib tofacitinib RB cord-254580-nhpjvgt4 143 10 - - HYPH cord-254580-nhpjvgt4 143 11 treated treat VBN cord-254580-nhpjvgt4 143 12 patients patient NNS cord-254580-nhpjvgt4 143 13 versus versus IN cord-254580-nhpjvgt4 143 14 none none NN cord-254580-nhpjvgt4 143 15 in in IN cord-254580-nhpjvgt4 143 16 the the DT cord-254580-nhpjvgt4 143 17 placebo placebo NN cord-254580-nhpjvgt4 143 18 groups group NNS cord-254580-nhpjvgt4 143 19 . . . cord-254580-nhpjvgt4 144 1 55 55 CD cord-254580-nhpjvgt4 145 1 Thus thus RB cord-254580-nhpjvgt4 145 2 , , , cord-254580-nhpjvgt4 145 3 tofacitinib tofacitinib NNP cord-254580-nhpjvgt4 145 4 has have VBZ cord-254580-nhpjvgt4 145 5 an an DT cord-254580-nhpjvgt4 145 6 association association NN cord-254580-nhpjvgt4 145 7 with with IN cord-254580-nhpjvgt4 145 8 increased increase VBN cord-254580-nhpjvgt4 145 9 infection infection NN cord-254580-nhpjvgt4 145 10 risk risk NN cord-254580-nhpjvgt4 145 11 in in IN cord-254580-nhpjvgt4 145 12 psoriasis psoriasis NN cord-254580-nhpjvgt4 145 13 / / SYM cord-254580-nhpjvgt4 145 14 psoriatic psoriatic JJ cord-254580-nhpjvgt4 145 15 arthritis arthritis NN cord-254580-nhpjvgt4 145 16 patients patient NNS cord-254580-nhpjvgt4 145 17 . . . cord-254580-nhpjvgt4 146 1 Tofacitinibtreated tofacitinibtreated JJ cord-254580-nhpjvgt4 146 2 patients patient NNS cord-254580-nhpjvgt4 146 3 may may MD cord-254580-nhpjvgt4 146 4 be be VB cord-254580-nhpjvgt4 146 5 more more RBR cord-254580-nhpjvgt4 146 6 susceptible susceptible JJ cord-254580-nhpjvgt4 146 7 to to IN cord-254580-nhpjvgt4 146 8 COVID-19 covid-19 JJ cord-254580-nhpjvgt4 146 9 , , , cord-254580-nhpjvgt4 146 10 strict strict JJ cord-254580-nhpjvgt4 146 11 protective protective JJ cord-254580-nhpjvgt4 146 12 measures measure NNS cord-254580-nhpjvgt4 146 13 are be VBP cord-254580-nhpjvgt4 146 14 recommended recommend VBN cord-254580-nhpjvgt4 146 15 to to TO cord-254580-nhpjvgt4 146 16 minimize minimize VB cord-254580-nhpjvgt4 146 17 viral viral JJ cord-254580-nhpjvgt4 146 18 exposure exposure NN cord-254580-nhpjvgt4 146 19 . . . cord-254580-nhpjvgt4 147 1 Dupilumab Dupilumab NNP cord-254580-nhpjvgt4 147 2 targets target NNS cord-254580-nhpjvgt4 147 3 IL-4 IL-4 NNP cord-254580-nhpjvgt4 147 4 and and CC cord-254580-nhpjvgt4 147 5 IL-13 IL-13 NNP cord-254580-nhpjvgt4 147 6 , , , cord-254580-nhpjvgt4 147 7 elements element NNS cord-254580-nhpjvgt4 147 8 of of IN cord-254580-nhpjvgt4 147 9 the the DT cord-254580-nhpjvgt4 147 10 type type NN cord-254580-nhpjvgt4 147 11 two two CD cord-254580-nhpjvgt4 147 12 immune immune JJ cord-254580-nhpjvgt4 147 13 response response NN cord-254580-nhpjvgt4 147 14 . . . cord-254580-nhpjvgt4 148 1 56 56 CD cord-254580-nhpjvgt4 149 1 As as IN cord-254580-nhpjvgt4 149 2 type type NN cord-254580-nhpjvgt4 149 3 one one CD cord-254580-nhpjvgt4 149 4 and and CC cord-254580-nhpjvgt4 149 5 type type VB cord-254580-nhpjvgt4 149 6 two two CD cord-254580-nhpjvgt4 149 7 immune immune JJ cord-254580-nhpjvgt4 149 8 responses response NNS cord-254580-nhpjvgt4 149 9 cross cross VBP cord-254580-nhpjvgt4 149 10 - - JJ cord-254580-nhpjvgt4 149 11 regulate regulate VBP cord-254580-nhpjvgt4 149 12 each each DT cord-254580-nhpjvgt4 149 13 other other JJ cord-254580-nhpjvgt4 149 14 , , , cord-254580-nhpjvgt4 149 15 suppression suppression NN cord-254580-nhpjvgt4 149 16 of of IN cord-254580-nhpjvgt4 149 17 type type NN cord-254580-nhpjvgt4 149 18 one one CD cord-254580-nhpjvgt4 149 19 immunity immunity NN cord-254580-nhpjvgt4 149 20 can can MD cord-254580-nhpjvgt4 149 21 potentially potentially RB cord-254580-nhpjvgt4 149 22 facilitate facilitate VB cord-254580-nhpjvgt4 149 23 uncontrolled uncontrolled JJ cord-254580-nhpjvgt4 149 24 or or CC cord-254580-nhpjvgt4 149 25 persistent persistent JJ cord-254580-nhpjvgt4 149 26 viral viral JJ cord-254580-nhpjvgt4 149 27 and and CC cord-254580-nhpjvgt4 149 28 bacterial bacterial JJ cord-254580-nhpjvgt4 149 29 infections infection NNS cord-254580-nhpjvgt4 149 30 . . . cord-254580-nhpjvgt4 150 1 57 57 CD cord-254580-nhpjvgt4 151 1 Nonetheless nonetheless RB cord-254580-nhpjvgt4 151 2 , , , cord-254580-nhpjvgt4 151 3 Dupilumab Dupilumab NNP cord-254580-nhpjvgt4 151 4 has have VBZ cord-254580-nhpjvgt4 151 5 been be VBN cord-254580-nhpjvgt4 151 6 associated associate VBN cord-254580-nhpjvgt4 151 7 with with IN cord-254580-nhpjvgt4 151 8 a a DT cord-254580-nhpjvgt4 151 9 reduced reduce VBN cord-254580-nhpjvgt4 151 10 infection infection NN cord-254580-nhpjvgt4 151 11 rate rate NN cord-254580-nhpjvgt4 151 12 in in IN cord-254580-nhpjvgt4 151 13 AD ad NN cord-254580-nhpjvgt4 151 14 patients patient NNS cord-254580-nhpjvgt4 151 15 . . . cord-254580-nhpjvgt4 152 1 A a DT cord-254580-nhpjvgt4 152 2 pooled pool VBN cord-254580-nhpjvgt4 152 3 analysis analysis NN cord-254580-nhpjvgt4 152 4 of of IN cord-254580-nhpjvgt4 152 5 seven seven CD cord-254580-nhpjvgt4 152 6 RCTs rct NNS cord-254580-nhpjvgt4 152 7 on on IN cord-254580-nhpjvgt4 152 8 dupilumab dupilumab NNP cord-254580-nhpjvgt4 152 9 - - HYPH cord-254580-nhpjvgt4 152 10 treated treat VBN cord-254580-nhpjvgt4 152 11 AD ad NN cord-254580-nhpjvgt4 152 12 adults adult NNS cord-254580-nhpjvgt4 152 13 showed show VBD cord-254580-nhpjvgt4 152 14 a a DT cord-254580-nhpjvgt4 152 15 decreased decreased JJ cord-254580-nhpjvgt4 152 16 risk risk NN cord-254580-nhpjvgt4 152 17 of of IN cord-254580-nhpjvgt4 152 18 serious serious JJ cord-254580-nhpjvgt4 152 19 infections infection NNS cord-254580-nhpjvgt4 152 20 , , , cord-254580-nhpjvgt4 152 21 skin skin NN cord-254580-nhpjvgt4 152 22 infections infection NNS cord-254580-nhpjvgt4 152 23 and and CC cord-254580-nhpjvgt4 152 24 herpes herpes NN cord-254580-nhpjvgt4 152 25 infections infection NNS cord-254580-nhpjvgt4 152 26 ( ( -LRB- cord-254580-nhpjvgt4 152 27 eczema eczema NN cord-254580-nhpjvgt4 152 28 herpeticum herpeticum NNP cord-254580-nhpjvgt4 152 29 or or CC cord-254580-nhpjvgt4 152 30 herpes herpes NNP cord-254580-nhpjvgt4 152 31 zoster zoster NNP cord-254580-nhpjvgt4 152 32 ) ) -RRB- cord-254580-nhpjvgt4 152 33 in in IN cord-254580-nhpjvgt4 152 34 the the DT cord-254580-nhpjvgt4 152 35 dupilumab dupilumab NN cord-254580-nhpjvgt4 152 36 groups group NNS cord-254580-nhpjvgt4 152 37 compared compare VBN cord-254580-nhpjvgt4 152 38 with with IN cord-254580-nhpjvgt4 152 39 placebo placebo NN cord-254580-nhpjvgt4 152 40 . . . cord-254580-nhpjvgt4 153 1 Furthermore furthermore RB cord-254580-nhpjvgt4 153 2 , , , cord-254580-nhpjvgt4 153 3 by by IN cord-254580-nhpjvgt4 153 4 also also RB cord-254580-nhpjvgt4 153 5 treating treat VBG cord-254580-nhpjvgt4 153 6 asthma asthma NN cord-254580-nhpjvgt4 153 7 , , , cord-254580-nhpjvgt4 153 8 dupilumab dupilumab NNP cord-254580-nhpjvgt4 153 9 may may MD cord-254580-nhpjvgt4 153 10 theoretically theoretically RB cord-254580-nhpjvgt4 153 11 decrease decrease VB cord-254580-nhpjvgt4 153 12 risk risk NN cord-254580-nhpjvgt4 153 13 for for IN cord-254580-nhpjvgt4 153 14 COVID-19 covid-19 JJ cord-254580-nhpjvgt4 153 15 infected infected JJ cord-254580-nhpjvgt4 153 16 patients patient NNS cord-254580-nhpjvgt4 153 17 for for IN cord-254580-nhpjvgt4 153 18 severe severe JJ cord-254580-nhpjvgt4 153 19 respiratory respiratory JJ cord-254580-nhpjvgt4 153 20 disease disease NN cord-254580-nhpjvgt4 153 21 . . . cord-254580-nhpjvgt4 154 1 56 56 CD cord-254580-nhpjvgt4 155 1 Therefore therefore RB cord-254580-nhpjvgt4 155 2 , , , cord-254580-nhpjvgt4 155 3 current current JJ cord-254580-nhpjvgt4 155 4 evidence evidence NN cord-254580-nhpjvgt4 155 5 suggests suggest VBZ cord-254580-nhpjvgt4 155 6 continuing continue VBG cord-254580-nhpjvgt4 155 7 and and CC cord-254580-nhpjvgt4 155 8 initiating initiate VBG cord-254580-nhpjvgt4 155 9 dupilumab dupilumab JJ cord-254580-nhpjvgt4 155 10 treatment treatment NN cord-254580-nhpjvgt4 155 11 in in IN cord-254580-nhpjvgt4 155 12 AD ad NN cord-254580-nhpjvgt4 155 13 patients patient NNS cord-254580-nhpjvgt4 155 14 during during IN cord-254580-nhpjvgt4 155 15 the the DT cord-254580-nhpjvgt4 155 16 COVID-19 COVID-19 NNP cord-254580-nhpjvgt4 155 17 pandemic pandemic NN cord-254580-nhpjvgt4 155 18 . . . cord-254580-nhpjvgt4 156 1 It -PRON- PRP cord-254580-nhpjvgt4 156 2 is be VBZ cord-254580-nhpjvgt4 156 3 difficult difficult JJ cord-254580-nhpjvgt4 156 4 to to TO cord-254580-nhpjvgt4 156 5 make make VB cord-254580-nhpjvgt4 156 6 definitive definitive JJ cord-254580-nhpjvgt4 156 7 conclusions conclusion NNS cord-254580-nhpjvgt4 156 8 about about IN cord-254580-nhpjvgt4 156 9 susceptibility susceptibility NN cord-254580-nhpjvgt4 156 10 to to IN cord-254580-nhpjvgt4 156 11 SARS SARS NNP cord-254580-nhpjvgt4 156 12 - - HYPH cord-254580-nhpjvgt4 156 13 CoV-2 CoV-2 NNP cord-254580-nhpjvgt4 156 14 infection infection NN cord-254580-nhpjvgt4 156 15 in in IN cord-254580-nhpjvgt4 156 16 psoriasis psoriasis NN cord-254580-nhpjvgt4 156 17 or or CC cord-254580-nhpjvgt4 156 18 AD ad NN cord-254580-nhpjvgt4 156 19 patients patient NNS cord-254580-nhpjvgt4 156 20 on on IN cord-254580-nhpjvgt4 156 21 systemic systemic JJ cord-254580-nhpjvgt4 156 22 treatments treatment NNS cord-254580-nhpjvgt4 156 23 , , , cord-254580-nhpjvgt4 156 24 solely solely RB cord-254580-nhpjvgt4 156 25 based base VBN cord-254580-nhpjvgt4 156 26 on on IN cord-254580-nhpjvgt4 156 27 general general JJ cord-254580-nhpjvgt4 156 28 infection infection NN cord-254580-nhpjvgt4 156 29 risk risk NN cord-254580-nhpjvgt4 156 30 data datum NNS cord-254580-nhpjvgt4 156 31 . . . cord-254580-nhpjvgt4 157 1 Furthermore furthermore RB cord-254580-nhpjvgt4 157 2 , , , cord-254580-nhpjvgt4 157 3 the the DT cord-254580-nhpjvgt4 157 4 majority majority NN cord-254580-nhpjvgt4 157 5 of of IN cord-254580-nhpjvgt4 157 6 studies study NNS cord-254580-nhpjvgt4 157 7 included include VBD cord-254580-nhpjvgt4 157 8 patients patient NNS cord-254580-nhpjvgt4 157 9 with with IN cord-254580-nhpjvgt4 157 10 mean mean JJ cord-254580-nhpjvgt4 157 11 age age NN cord-254580-nhpjvgt4 157 12 of of IN cord-254580-nhpjvgt4 157 13 approximately approximately RB cord-254580-nhpjvgt4 157 14 40 40 CD cord-254580-nhpjvgt4 157 15 years year NNS cord-254580-nhpjvgt4 157 16 ; ; : cord-254580-nhpjvgt4 157 17 therefore therefore RB cord-254580-nhpjvgt4 157 18 , , , cord-254580-nhpjvgt4 157 19 these these DT cord-254580-nhpjvgt4 157 20 recommendations recommendation NNS cord-254580-nhpjvgt4 157 21 may may MD cord-254580-nhpjvgt4 157 22 not not RB cord-254580-nhpjvgt4 157 23 be be VB cord-254580-nhpjvgt4 157 24 applicable applicable JJ cord-254580-nhpjvgt4 157 25 to to IN cord-254580-nhpjvgt4 157 26 older old JJR cord-254580-nhpjvgt4 157 27 individuals individual NNS cord-254580-nhpjvgt4 157 28 , , , cord-254580-nhpjvgt4 157 29 who who WP cord-254580-nhpjvgt4 157 30 on on IN cord-254580-nhpjvgt4 157 31 average average JJ cord-254580-nhpjvgt4 157 32 have have VBP cord-254580-nhpjvgt4 157 33 higher high JJR cord-254580-nhpjvgt4 157 34 COVID-19 covid-19 NN cord-254580-nhpjvgt4 157 35 associated associated JJ cord-254580-nhpjvgt4 157 36 mortality mortality NN cord-254580-nhpjvgt4 157 37 . . . cord-254580-nhpjvgt4 158 1 There there EX cord-254580-nhpjvgt4 158 2 is be VBZ cord-254580-nhpjvgt4 158 3 also also RB cord-254580-nhpjvgt4 158 4 a a DT cord-254580-nhpjvgt4 158 5 potential potential JJ cord-254580-nhpjvgt4 158 6 role role NN cord-254580-nhpjvgt4 158 7 for for IN cord-254580-nhpjvgt4 158 8 some some DT cord-254580-nhpjvgt4 158 9 of of IN cord-254580-nhpjvgt4 158 10 these these DT cord-254580-nhpjvgt4 158 11 medications medication NNS cord-254580-nhpjvgt4 158 12 as as IN cord-254580-nhpjvgt4 158 13 treatments treatment NNS cord-254580-nhpjvgt4 158 14 of of IN cord-254580-nhpjvgt4 158 15 COVID-19 covid-19 NN cord-254580-nhpjvgt4 158 16 but but CC cord-254580-nhpjvgt4 158 17 this this DT cord-254580-nhpjvgt4 158 18 remains remain VBZ cord-254580-nhpjvgt4 158 19 largely largely RB cord-254580-nhpjvgt4 158 20 unknown unknown JJ cord-254580-nhpjvgt4 158 21 . . . cord-254580-nhpjvgt4 159 1 In in IN cord-254580-nhpjvgt4 159 2 We -PRON- PRP cord-254580-nhpjvgt4 159 3 suggest suggest VBP cord-254580-nhpjvgt4 159 4 the the DT cord-254580-nhpjvgt4 159 5 following follow VBG cord-254580-nhpjvgt4 159 6 algorithms algorithm NNS cord-254580-nhpjvgt4 159 7 for for IN cord-254580-nhpjvgt4 159 8 treatment treatment NN cord-254580-nhpjvgt4 159 9 of of IN cord-254580-nhpjvgt4 159 10 psoriasis psoriasis NN cord-254580-nhpjvgt4 159 11 and and CC cord-254580-nhpjvgt4 159 12 AD ad NN cord-254580-nhpjvgt4 159 13 during during IN cord-254580-nhpjvgt4 159 14 the the DT cord-254580-nhpjvgt4 159 15 COVID-19 covid-19 JJ cord-254580-nhpjvgt4 159 16 pandemic pandemic NN cord-254580-nhpjvgt4 159 17 ( ( -LRB- cord-254580-nhpjvgt4 159 18 Figures figure NNS cord-254580-nhpjvgt4 159 19 1 1 CD cord-254580-nhpjvgt4 159 20 , , , cord-254580-nhpjvgt4 159 21 2 2 CD cord-254580-nhpjvgt4 159 22 ) ) -RRB- cord-254580-nhpjvgt4 159 23 . . . cord-254580-nhpjvgt4 160 1 This this DT cord-254580-nhpjvgt4 160 2 article article NN cord-254580-nhpjvgt4 160 3 is be VBZ cord-254580-nhpjvgt4 160 4 protected protect VBN cord-254580-nhpjvgt4 160 5 by by IN cord-254580-nhpjvgt4 160 6 copyright copyright NN cord-254580-nhpjvgt4 160 7 . . . cord-254580-nhpjvgt4 161 1 All all DT cord-254580-nhpjvgt4 161 2 rights right NNS cord-254580-nhpjvgt4 161 3 reserved reserve VBN cord-254580-nhpjvgt4 161 4 . . . cord-254580-nhpjvgt4 162 1 This this DT cord-254580-nhpjvgt4 162 2 article article NN cord-254580-nhpjvgt4 162 3 is be VBZ cord-254580-nhpjvgt4 162 4 protected protect VBN cord-254580-nhpjvgt4 162 5 by by IN cord-254580-nhpjvgt4 162 6 copyright copyright NN cord-254580-nhpjvgt4 162 7 . . . cord-254580-nhpjvgt4 163 1 All all DT cord-254580-nhpjvgt4 163 2 rights right NNS cord-254580-nhpjvgt4 163 3 reserved reserve VBN cord-254580-nhpjvgt4 163 4 . . . cord-254580-nhpjvgt4 164 1 This this DT cord-254580-nhpjvgt4 164 2 article article NN cord-254580-nhpjvgt4 164 3 is be VBZ cord-254580-nhpjvgt4 164 4 protected protect VBN cord-254580-nhpjvgt4 164 5 by by IN cord-254580-nhpjvgt4 164 6 copyright copyright NN cord-254580-nhpjvgt4 164 7 . . . cord-254580-nhpjvgt4 165 1 All all DT cord-254580-nhpjvgt4 165 2 rights right NNS cord-254580-nhpjvgt4 165 3 reserved reserve VBN cord-254580-nhpjvgt4 165 4 . . . cord-254580-nhpjvgt4 166 1 This this DT cord-254580-nhpjvgt4 166 2 article article NN cord-254580-nhpjvgt4 166 3 is be VBZ cord-254580-nhpjvgt4 166 4 protected protect VBN cord-254580-nhpjvgt4 166 5 by by IN cord-254580-nhpjvgt4 166 6 copyright copyright NN cord-254580-nhpjvgt4 166 7 . . . cord-254580-nhpjvgt4 167 1 All all DT cord-254580-nhpjvgt4 167 2 rights right NNS cord-254580-nhpjvgt4 167 3 reserved reserve VBN cord-254580-nhpjvgt4 167 4 . . . cord-254580-nhpjvgt4 168 1 This this DT cord-254580-nhpjvgt4 168 2 article article NN cord-254580-nhpjvgt4 168 3 is be VBZ cord-254580-nhpjvgt4 168 4 protected protect VBN cord-254580-nhpjvgt4 168 5 by by IN cord-254580-nhpjvgt4 168 6 copyright copyright NN cord-254580-nhpjvgt4 168 7 . . . cord-254580-nhpjvgt4 169 1 All all DT cord-254580-nhpjvgt4 169 2 rights right NNS cord-254580-nhpjvgt4 169 3 reserved reserve VBN cord-254580-nhpjvgt4 169 4 . . . cord-254580-nhpjvgt4 169 5 _SP cord-254580-nhpjvgt4 170 1 Coronavirus Coronavirus NNP cord-254580-nhpjvgt4 170 2 COVID-19 COVID-19 NNP cord-254580-nhpjvgt4 170 3 Global Global NNP cord-254580-nhpjvgt4 170 4 Cases Cases NNPS cord-254580-nhpjvgt4 170 5 by by IN cord-254580-nhpjvgt4 170 6 the the DT cord-254580-nhpjvgt4 170 7 Cross Cross NNP cord-254580-nhpjvgt4 170 8 - - HYPH cord-254580-nhpjvgt4 170 9 Country Country NNP cord-254580-nhpjvgt4 170 10 Comparison Comparison NNP cord-254580-nhpjvgt4 170 11 of of IN cord-254580-nhpjvgt4 170 12 Case Case NNP cord-254580-nhpjvgt4 170 13 Fatality Fatality NNP cord-254580-nhpjvgt4 170 14 Rates rate NNS cord-254580-nhpjvgt4 170 15 of of IN cord-254580-nhpjvgt4 170 16 COVID COVID NNP cord-254580-nhpjvgt4 170 17 Sleep Sleep NNP cord-254580-nhpjvgt4 170 18 disturbances disturbance NNS cord-254580-nhpjvgt4 170 19 in in IN cord-254580-nhpjvgt4 170 20 adults adult NNS cord-254580-nhpjvgt4 170 21 with with IN cord-254580-nhpjvgt4 170 22 eczema eczema NN cord-254580-nhpjvgt4 170 23 are be VBP cord-254580-nhpjvgt4 170 24 associated associate VBN cord-254580-nhpjvgt4 170 25 with with IN cord-254580-nhpjvgt4 170 26 impaired impaired JJ cord-254580-nhpjvgt4 170 27 overall overall JJ cord-254580-nhpjvgt4 170 28 health health NN cord-254580-nhpjvgt4 170 29 : : : cord-254580-nhpjvgt4 170 30 a a DT cord-254580-nhpjvgt4 170 31 US US NNP cord-254580-nhpjvgt4 170 32 population population NN cord-254580-nhpjvgt4 170 33 - - HYPH cord-254580-nhpjvgt4 170 34 based base VBN cord-254580-nhpjvgt4 170 35 study study NN cord-254580-nhpjvgt4 170 36 National National NNP cord-254580-nhpjvgt4 170 37 Health Health NNP cord-254580-nhpjvgt4 170 38 and and CC cord-254580-nhpjvgt4 170 39 Nutrition Nutrition NNP cord-254580-nhpjvgt4 170 40 Examination Examination NNP cord-254580-nhpjvgt4 170 41 Surveys Surveys NNPS cord-254580-nhpjvgt4 170 42 Atopic Atopic NNP cord-254580-nhpjvgt4 170 43 dermatitis dermatitis NN cord-254580-nhpjvgt4 170 44 and and CC cord-254580-nhpjvgt4 170 45 psoriasis psoriasis NN cord-254580-nhpjvgt4 170 46 : : : cord-254580-nhpjvgt4 170 47 two two CD cord-254580-nhpjvgt4 170 48 different different JJ cord-254580-nhpjvgt4 170 49 immune immune JJ cord-254580-nhpjvgt4 170 50 diseases disease NNS cord-254580-nhpjvgt4 170 51 or or CC cord-254580-nhpjvgt4 170 52 one one CD cord-254580-nhpjvgt4 170 53 spectrum spectrum NN cord-254580-nhpjvgt4 170 54 ? ? . cord-254580-nhpjvgt4 171 1 Recategorization recategorization NN cord-254580-nhpjvgt4 171 2 of of IN cord-254580-nhpjvgt4 171 3 psoriasis psoriasis NN cord-254580-nhpjvgt4 171 4 severity severity NN cord-254580-nhpjvgt4 171 5 : : : cord-254580-nhpjvgt4 171 6 Delphi Delphi NNP cord-254580-nhpjvgt4 171 7 consensus consensus NN cord-254580-nhpjvgt4 171 8 from from IN cord-254580-nhpjvgt4 171 9 the the DT cord-254580-nhpjvgt4 171 10 International International NNP cord-254580-nhpjvgt4 171 11 Psoriasis Psoriasis NNP cord-254580-nhpjvgt4 171 12 Council Council NNP cord-254580-nhpjvgt4 171 13 Systemic Systemic NNP cord-254580-nhpjvgt4 171 14 Treatment Treatment NNP cord-254580-nhpjvgt4 171 15 of of IN cord-254580-nhpjvgt4 171 16 Adult Adult NNP cord-254580-nhpjvgt4 171 17 Atopic Atopic NNP cord-254580-nhpjvgt4 171 18 Dermatitis dermatitis NN cord-254580-nhpjvgt4 171 19 : : : cord-254580-nhpjvgt4 172 1 A a DT cord-254580-nhpjvgt4 172 2 Review Review NNP cord-254580-nhpjvgt4 172 3 Systematic Systematic NNP cord-254580-nhpjvgt4 172 4 Review Review NNP cord-254580-nhpjvgt4 172 5 of of IN cord-254580-nhpjvgt4 172 6 the the DT cord-254580-nhpjvgt4 172 7 Toxicity toxicity NN cord-254580-nhpjvgt4 172 8 of of IN cord-254580-nhpjvgt4 172 9 Long long JJ cord-254580-nhpjvgt4 172 10 - - HYPH cord-254580-nhpjvgt4 172 11 Course course NN cord-254580-nhpjvgt4 172 12 Oral oral JJ cord-254580-nhpjvgt4 172 13 Corticosteroids Corticosteroids NNPS cord-254580-nhpjvgt4 172 14 in in IN cord-254580-nhpjvgt4 172 15 Children child NNS cord-254580-nhpjvgt4 173 1 The the DT cord-254580-nhpjvgt4 173 2 effect effect NN cord-254580-nhpjvgt4 173 3 of of IN cord-254580-nhpjvgt4 173 4 corticosteroids corticosteroid NNS cord-254580-nhpjvgt4 173 5 on on IN cord-254580-nhpjvgt4 173 6 mortality mortality NN cord-254580-nhpjvgt4 173 7 of of IN cord-254580-nhpjvgt4 173 8 patients patient NNS cord-254580-nhpjvgt4 173 9 with with IN cord-254580-nhpjvgt4 173 10 influenza influenza NN cord-254580-nhpjvgt4 173 11 pneumonia pneumonia NN cord-254580-nhpjvgt4 173 12 : : : cord-254580-nhpjvgt4 173 13 a a DT cord-254580-nhpjvgt4 173 14 systematic systematic JJ cord-254580-nhpjvgt4 173 15 review review NN cord-254580-nhpjvgt4 173 16 and and CC cord-254580-nhpjvgt4 173 17 meta meta NNP cord-254580-nhpjvgt4 173 18 - - HYPH cord-254580-nhpjvgt4 173 19 analysis analysis NN cord-254580-nhpjvgt4 173 20 Infections infection NNS cord-254580-nhpjvgt4 173 21 in in IN cord-254580-nhpjvgt4 173 22 Moderate moderate JJ cord-254580-nhpjvgt4 173 23 to to IN cord-254580-nhpjvgt4 173 24 Severe severe JJ cord-254580-nhpjvgt4 173 25 Psoriasis psoriasis NN cord-254580-nhpjvgt4 173 26 Patients patient NNS cord-254580-nhpjvgt4 173 27 Treated treat VBN cord-254580-nhpjvgt4 173 28 with with IN cord-254580-nhpjvgt4 173 29 Biological biological JJ cord-254580-nhpjvgt4 173 30 Drugs drug NNS cord-254580-nhpjvgt4 174 1 Compared compare VBN cord-254580-nhpjvgt4 174 2 to to IN cord-254580-nhpjvgt4 174 3 Classic classic JJ cord-254580-nhpjvgt4 174 4 Systemic systemic JJ cord-254580-nhpjvgt4 174 5 Drugs drug NNS cord-254580-nhpjvgt4 174 6 : : : cord-254580-nhpjvgt4 174 7 Findings finding NNS cord-254580-nhpjvgt4 174 8 from from IN cord-254580-nhpjvgt4 174 9 the the DT cord-254580-nhpjvgt4 174 10 BIOBADADERM BIOBADADERM NNP cord-254580-nhpjvgt4 174 11 Registry Registry NNP cord-254580-nhpjvgt4 174 12 Methotrexate Methotrexate NNP cord-254580-nhpjvgt4 174 13 Versus Versus NNP cord-254580-nhpjvgt4 174 14 Cyclosporine Cyclosporine NNP cord-254580-nhpjvgt4 174 15 in in IN cord-254580-nhpjvgt4 174 16 Adults Adults NNPS cord-254580-nhpjvgt4 174 17 with with IN cord-254580-nhpjvgt4 174 18 Moderate moderate JJ cord-254580-nhpjvgt4 174 19 - - HYPH cord-254580-nhpjvgt4 174 20 to to IN cord-254580-nhpjvgt4 174 21 - - HYPH cord-254580-nhpjvgt4 174 22 Severe severe JJ cord-254580-nhpjvgt4 174 23 Atopic Atopic NNP cord-254580-nhpjvgt4 174 24 Dermatitis dermatitis NN cord-254580-nhpjvgt4 174 25 : : : cord-254580-nhpjvgt4 174 26 A a DT cord-254580-nhpjvgt4 174 27 Phase phase NN cord-254580-nhpjvgt4 174 28 III iii CD cord-254580-nhpjvgt4 174 29 Randomized randomized JJ cord-254580-nhpjvgt4 174 30 Noninferiority Noninferiority NNP cord-254580-nhpjvgt4 174 31 Trial Trial NNP cord-254580-nhpjvgt4 174 32 Comparative Comparative NNP cord-254580-nhpjvgt4 174 33 Safety Safety NNP cord-254580-nhpjvgt4 174 34 of of IN cord-254580-nhpjvgt4 174 35 Systemic Systemic NNP cord-254580-nhpjvgt4 174 36 Immuno immuno JJ cord-254580-nhpjvgt4 174 37 - - HYPH cord-254580-nhpjvgt4 174 38 modulatory modulatory JJ cord-254580-nhpjvgt4 174 39 Medications medication NNS cord-254580-nhpjvgt4 174 40 in in IN cord-254580-nhpjvgt4 174 41 Adults Adults NNPS cord-254580-nhpjvgt4 174 42 with with IN cord-254580-nhpjvgt4 174 43 Atopic Atopic NNP cord-254580-nhpjvgt4 174 44 Dermatitis Dermatitis NNP cord-254580-nhpjvgt4 174 45 Suppression Suppression NNP cord-254580-nhpjvgt4 174 46 of of IN cord-254580-nhpjvgt4 174 47 coronavirus coronavirus NN cord-254580-nhpjvgt4 174 48 replication replication NN cord-254580-nhpjvgt4 174 49 by by IN cord-254580-nhpjvgt4 174 50 cyclophilin cyclophilin NNP cord-254580-nhpjvgt4 174 51 inhibitors inhibitor NNS cord-254580-nhpjvgt4 175 1 A a DT cord-254580-nhpjvgt4 175 2 review review NN cord-254580-nhpjvgt4 175 3 of of IN cord-254580-nhpjvgt4 175 4 its -PRON- PRP$ cord-254580-nhpjvgt4 175 5 pharmacology pharmacology NN cord-254580-nhpjvgt4 175 6 and and CC cord-254580-nhpjvgt4 175 7 therapeutic therapeutic JJ cord-254580-nhpjvgt4 175 8 use use NN cord-254580-nhpjvgt4 175 9 Risk risk NN cord-254580-nhpjvgt4 175 10 of of IN cord-254580-nhpjvgt4 175 11 Serious serious JJ cord-254580-nhpjvgt4 175 12 Infection infection NN cord-254580-nhpjvgt4 175 13 in in IN cord-254580-nhpjvgt4 175 14 Patients patient NNS cord-254580-nhpjvgt4 175 15 Receiving receive VBG cord-254580-nhpjvgt4 175 16 Systemic systemic JJ cord-254580-nhpjvgt4 175 17 Medications medication NNS cord-254580-nhpjvgt4 175 18 for for IN cord-254580-nhpjvgt4 175 19 the the DT cord-254580-nhpjvgt4 175 20 Treatment Treatment NNP cord-254580-nhpjvgt4 175 21 of of IN cord-254580-nhpjvgt4 175 22 Psoriasis Psoriasis NNP cord-254580-nhpjvgt4 176 1 Retinoic retinoic JJ cord-254580-nhpjvgt4 176 2 acid acid NN cord-254580-nhpjvgt4 176 3 analogues analogue NNS cord-254580-nhpjvgt4 176 4 inhibit inhibit VBP cord-254580-nhpjvgt4 176 5 human human JJ cord-254580-nhpjvgt4 176 6 herpesvirus herpesvirus NN cord-254580-nhpjvgt4 176 7 8 8 CD cord-254580-nhpjvgt4 176 8 replication replication NN cord-254580-nhpjvgt4 176 9 Adalimumab Adalimumab NNP cord-254580-nhpjvgt4 176 10 therapy therapy NN cord-254580-nhpjvgt4 176 11 for for IN cord-254580-nhpjvgt4 176 12 moderate moderate JJ cord-254580-nhpjvgt4 176 13 to to IN cord-254580-nhpjvgt4 176 14 severe severe JJ cord-254580-nhpjvgt4 176 15 psoriasis psoriasis NN cord-254580-nhpjvgt4 176 16 : : : cord-254580-nhpjvgt4 177 1 A a DT cord-254580-nhpjvgt4 177 2 randomized randomized JJ cord-254580-nhpjvgt4 177 3 , , , cord-254580-nhpjvgt4 177 4 controlled control VBN cord-254580-nhpjvgt4 177 5 phase phase NN cord-254580-nhpjvgt4 177 6 III iii CD cord-254580-nhpjvgt4 177 7 trial trial NN cord-254580-nhpjvgt4 177 8 Efficacy Efficacy NNP cord-254580-nhpjvgt4 177 9 and and CC cord-254580-nhpjvgt4 177 10 safety safety NN cord-254580-nhpjvgt4 177 11 of of IN cord-254580-nhpjvgt4 177 12 guselkumab guselkumab NNS cord-254580-nhpjvgt4 177 13 , , , cord-254580-nhpjvgt4 177 14 an an DT cord-254580-nhpjvgt4 177 15 anti anti JJ cord-254580-nhpjvgt4 177 16 - - JJ cord-254580-nhpjvgt4 177 17 interleukin-23 interleukin-23 JJ cord-254580-nhpjvgt4 177 18 monoclonal monoclonal JJ cord-254580-nhpjvgt4 177 19 antibody antibody NN cord-254580-nhpjvgt4 177 20 , , , cord-254580-nhpjvgt4 177 21 compared compare VBN cord-254580-nhpjvgt4 177 22 with with IN cord-254580-nhpjvgt4 177 23 adalimumab adalimumab NNS cord-254580-nhpjvgt4 177 24 for for IN cord-254580-nhpjvgt4 177 25 the the DT cord-254580-nhpjvgt4 177 26 treatment treatment NN cord-254580-nhpjvgt4 177 27 of of IN cord-254580-nhpjvgt4 177 28 patients patient NNS cord-254580-nhpjvgt4 177 29 with with IN cord-254580-nhpjvgt4 177 30 moderate moderate JJ cord-254580-nhpjvgt4 177 31 to to IN cord-254580-nhpjvgt4 177 32 severe severe JJ cord-254580-nhpjvgt4 177 33 psoriasis psoriasis NN cord-254580-nhpjvgt4 177 34 with with IN cord-254580-nhpjvgt4 177 35 randomized randomized JJ cord-254580-nhpjvgt4 177 36 withdrawal withdrawal NN cord-254580-nhpjvgt4 177 37 and and CC cord-254580-nhpjvgt4 177 38 retreatment retreatment NN cord-254580-nhpjvgt4 177 39 : : : cord-254580-nhpjvgt4 177 40 Results result NNS cord-254580-nhpjvgt4 177 41 from from IN cord-254580-nhpjvgt4 177 42 the the DT cord-254580-nhpjvgt4 177 43 phase phase NN cord-254580-nhpjvgt4 177 44 III iii CD cord-254580-nhpjvgt4 177 45 , , , cord-254580-nhpjvgt4 177 46 double double JJ cord-254580-nhpjvgt4 177 47 - - HYPH cord-254580-nhpjvgt4 177 48 blind blind JJ cord-254580-nhpjvgt4 177 49 , , , cord-254580-nhpjvgt4 177 50 placebo placebo NN cord-254580-nhpjvgt4 177 51 - - HYPH cord-254580-nhpjvgt4 177 52 and and CC cord-254580-nhpjvgt4 177 53 active active JJ cord-254580-nhpjvgt4 177 54 comparator comparator NN cord-254580-nhpjvgt4 177 55 - - HYPH cord-254580-nhpjvgt4 177 56 controlled control VBN cord-254580-nhpjvgt4 177 57 VOYAGE voyage NN cord-254580-nhpjvgt4 177 58 2 2 CD cord-254580-nhpjvgt4 177 59 trial trial NN cord-254580-nhpjvgt4 177 60 Etanercept Etanercept NNP cord-254580-nhpjvgt4 177 61 in in IN cord-254580-nhpjvgt4 177 62 the the DT cord-254580-nhpjvgt4 177 63 treatment treatment NN cord-254580-nhpjvgt4 177 64 of of IN cord-254580-nhpjvgt4 177 65 psoriatic psoriatic JJ cord-254580-nhpjvgt4 177 66 arthritis arthritis NN cord-254580-nhpjvgt4 177 67 and and CC cord-254580-nhpjvgt4 177 68 psoriasis psoriasis NN cord-254580-nhpjvgt4 177 69 : : : cord-254580-nhpjvgt4 177 70 a a DT cord-254580-nhpjvgt4 177 71 randomised randomised JJ cord-254580-nhpjvgt4 177 72 trial trial NN cord-254580-nhpjvgt4 177 73 Secukinumab Secukinumab NNP cord-254580-nhpjvgt4 177 74 in in IN cord-254580-nhpjvgt4 177 75 plaque plaque NN cord-254580-nhpjvgt4 177 76 psoriasis psoriasis NN cord-254580-nhpjvgt4 177 77 -- -- : cord-254580-nhpjvgt4 177 78 results result NNS cord-254580-nhpjvgt4 177 79 of of IN cord-254580-nhpjvgt4 177 80 two two CD cord-254580-nhpjvgt4 177 81 phase phase NN cord-254580-nhpjvgt4 177 82 3 3 CD cord-254580-nhpjvgt4 177 83 trials trial NNS cord-254580-nhpjvgt4 178 1 Infliximab Infliximab NNP cord-254580-nhpjvgt4 178 2 monotherapy monotherapy RB cord-254580-nhpjvgt4 178 3 provides provide VBZ cord-254580-nhpjvgt4 178 4 rapid rapid JJ cord-254580-nhpjvgt4 178 5 and and CC cord-254580-nhpjvgt4 178 6 sustained sustained JJ cord-254580-nhpjvgt4 178 7 benefit benefit NN cord-254580-nhpjvgt4 178 8 for for IN cord-254580-nhpjvgt4 178 9 plaque plaque NN cord-254580-nhpjvgt4 178 10 - - HYPH cord-254580-nhpjvgt4 178 11 type type NN cord-254580-nhpjvgt4 178 12 psoriasis psoriasis NN cord-254580-nhpjvgt4 179 1 Infliximab Infliximab NNP cord-254580-nhpjvgt4 179 2 induction induction NN cord-254580-nhpjvgt4 179 3 and and CC cord-254580-nhpjvgt4 179 4 maintenance maintenance NN cord-254580-nhpjvgt4 179 5 therapy therapy NN cord-254580-nhpjvgt4 179 6 for for IN cord-254580-nhpjvgt4 179 7 moderate moderate JJ cord-254580-nhpjvgt4 179 8 - - HYPH cord-254580-nhpjvgt4 179 9 to to IN cord-254580-nhpjvgt4 179 10 - - HYPH cord-254580-nhpjvgt4 179 11 severe severe JJ cord-254580-nhpjvgt4 179 12 psoriasis psoriasis NN cord-254580-nhpjvgt4 179 13 : : : cord-254580-nhpjvgt4 179 14 a a DT cord-254580-nhpjvgt4 179 15 phase phase NN cord-254580-nhpjvgt4 179 16 III III NNP cord-254580-nhpjvgt4 179 17 , , , cord-254580-nhpjvgt4 179 18 multicentre multicentre NNP cord-254580-nhpjvgt4 179 19 , , , cord-254580-nhpjvgt4 179 20 double double JJ cord-254580-nhpjvgt4 179 21 - - HYPH cord-254580-nhpjvgt4 179 22 blind blind JJ cord-254580-nhpjvgt4 179 23 trial trial NN cord-254580-nhpjvgt4 180 1 A a DT cord-254580-nhpjvgt4 180 2 randomized randomized JJ cord-254580-nhpjvgt4 180 3 comparison comparison NN cord-254580-nhpjvgt4 180 4 of of IN cord-254580-nhpjvgt4 180 5 continuous continuous JJ cord-254580-nhpjvgt4 180 6 vs vs IN cord-254580-nhpjvgt4 180 7 year year NN cord-254580-nhpjvgt4 180 8 in in IN cord-254580-nhpjvgt4 180 9 the the DT cord-254580-nhpjvgt4 180 10 treatment treatment NN cord-254580-nhpjvgt4 180 11 of of IN cord-254580-nhpjvgt4 180 12 moderate moderate JJ cord-254580-nhpjvgt4 180 13 - - HYPH cord-254580-nhpjvgt4 180 14 to to IN cord-254580-nhpjvgt4 180 15 - - HYPH cord-254580-nhpjvgt4 180 16 severe severe JJ cord-254580-nhpjvgt4 180 17 plaque plaque NN cord-254580-nhpjvgt4 180 18 psoriasis psoriasis NN cord-254580-nhpjvgt4 180 19 Certolizumab Certolizumab NNP cord-254580-nhpjvgt4 180 20 pegol pegol NN cord-254580-nhpjvgt4 180 21 for for IN cord-254580-nhpjvgt4 180 22 the the DT cord-254580-nhpjvgt4 180 23 treatment treatment NN cord-254580-nhpjvgt4 180 24 of of IN cord-254580-nhpjvgt4 180 25 patients patient NNS cord-254580-nhpjvgt4 180 26 with with IN cord-254580-nhpjvgt4 180 27 moderate moderate JJ cord-254580-nhpjvgt4 180 28 - - HYPH cord-254580-nhpjvgt4 180 29 to to IN cord-254580-nhpjvgt4 180 30 - - HYPH cord-254580-nhpjvgt4 180 31 severe severe JJ cord-254580-nhpjvgt4 180 32 chronic chronic JJ cord-254580-nhpjvgt4 180 33 plaque plaque NN cord-254580-nhpjvgt4 180 34 psoriasis psoriasis NN cord-254580-nhpjvgt4 180 35 : : : cord-254580-nhpjvgt4 180 36 pooled pool VBN cord-254580-nhpjvgt4 180 37 analysis analysis NN cord-254580-nhpjvgt4 180 38 of of IN cord-254580-nhpjvgt4 180 39 week week NN cord-254580-nhpjvgt4 180 40 16 16 CD cord-254580-nhpjvgt4 180 41 data datum NNS cord-254580-nhpjvgt4 180 42 from from IN cord-254580-nhpjvgt4 180 43 three three CD cord-254580-nhpjvgt4 180 44 randomized randomized JJ cord-254580-nhpjvgt4 180 45 controlled control VBN cord-254580-nhpjvgt4 180 46 trials trial NNS cord-254580-nhpjvgt4 180 47 Guselkumab Guselkumab NNP cord-254580-nhpjvgt4 180 48 versus versus IN cord-254580-nhpjvgt4 180 49 secukinumab secukinumab NNS cord-254580-nhpjvgt4 180 50 for for IN cord-254580-nhpjvgt4 180 51 the the DT cord-254580-nhpjvgt4 180 52 treatment treatment NN cord-254580-nhpjvgt4 180 53 of of IN cord-254580-nhpjvgt4 180 54 moderate moderate JJ cord-254580-nhpjvgt4 180 55 - - HYPH cord-254580-nhpjvgt4 180 56 to to IN cord-254580-nhpjvgt4 180 57 - - HYPH cord-254580-nhpjvgt4 180 58 severe severe JJ cord-254580-nhpjvgt4 180 59 psoriasis psoriasis NN cord-254580-nhpjvgt4 180 60 ( ( -LRB- cord-254580-nhpjvgt4 180 61 ECLIPSE ECLIPSE NNP cord-254580-nhpjvgt4 180 62 ) ) -RRB- cord-254580-nhpjvgt4 180 63 : : : cord-254580-nhpjvgt4 180 64 results result NNS cord-254580-nhpjvgt4 180 65 from from IN cord-254580-nhpjvgt4 180 66 a a DT cord-254580-nhpjvgt4 180 67 phase phase NN cord-254580-nhpjvgt4 180 68 3 3 CD cord-254580-nhpjvgt4 180 69 , , , cord-254580-nhpjvgt4 180 70 randomised randomise VBN cord-254580-nhpjvgt4 180 71 controlled control VBN cord-254580-nhpjvgt4 180 72 trial trial NN cord-254580-nhpjvgt4 180 73 Longterm longterm JJ cord-254580-nhpjvgt4 180 74 safety safety NN cord-254580-nhpjvgt4 180 75 profile profile NN cord-254580-nhpjvgt4 180 76 of of IN cord-254580-nhpjvgt4 180 77 ixekizumab ixekizumab NNP cord-254580-nhpjvgt4 180 78 in in IN cord-254580-nhpjvgt4 180 79 patients patient NNS cord-254580-nhpjvgt4 180 80 with with IN cord-254580-nhpjvgt4 180 81 moderate moderate JJ cord-254580-nhpjvgt4 180 82 - - HYPH cord-254580-nhpjvgt4 180 83 to to IN cord-254580-nhpjvgt4 180 84 - - HYPH cord-254580-nhpjvgt4 180 85 severe severe JJ cord-254580-nhpjvgt4 180 86 plaque plaque NN cord-254580-nhpjvgt4 180 87 psoriasis psoriasis NN cord-254580-nhpjvgt4 180 88 : : : cord-254580-nhpjvgt4 180 89 an an DT cord-254580-nhpjvgt4 180 90 integrated integrated JJ cord-254580-nhpjvgt4 180 91 analysis analysis NN cord-254580-nhpjvgt4 180 92 from from IN cord-254580-nhpjvgt4 180 93 11 11 CD cord-254580-nhpjvgt4 180 94 clinical clinical JJ cord-254580-nhpjvgt4 180 95 trials trial NNS cord-254580-nhpjvgt4 180 96 Ixekizumab Ixekizumab NNP cord-254580-nhpjvgt4 180 97 Treatment Treatment NNP cord-254580-nhpjvgt4 180 98 for for IN cord-254580-nhpjvgt4 180 99 up up IN cord-254580-nhpjvgt4 180 100 to to TO cord-254580-nhpjvgt4 180 101 5 5 CD cord-254580-nhpjvgt4 180 102 Years year NNS cord-254580-nhpjvgt4 180 103 in in IN cord-254580-nhpjvgt4 180 104 Adult Adult NNP cord-254580-nhpjvgt4 180 105 Patients Patients NNP cord-254580-nhpjvgt4 180 106 with with IN cord-254580-nhpjvgt4 180 107 Moderate moderate JJ cord-254580-nhpjvgt4 180 108 - - HYPH cord-254580-nhpjvgt4 180 109 to to IN cord-254580-nhpjvgt4 180 110 - - HYPH cord-254580-nhpjvgt4 180 111 Severe severe JJ cord-254580-nhpjvgt4 180 112 Psoriasis psoriasis NN cord-254580-nhpjvgt4 180 113 : : : cord-254580-nhpjvgt4 180 114 Results result NNS cord-254580-nhpjvgt4 180 115 from from IN cord-254580-nhpjvgt4 180 116 Greater Greater NNP cord-254580-nhpjvgt4 180 117 Than than IN cord-254580-nhpjvgt4 180 118 17,000 17,000 CD cord-254580-nhpjvgt4 180 119 Patient Patient NNP cord-254580-nhpjvgt4 180 120 - - HYPH cord-254580-nhpjvgt4 180 121 Years year NNS cord-254580-nhpjvgt4 180 122 of of IN cord-254580-nhpjvgt4 180 123 Exposure Exposure NNP cord-254580-nhpjvgt4 180 124 A a DT cord-254580-nhpjvgt4 180 125 prospective prospective JJ cord-254580-nhpjvgt4 180 126 phase phase NN cord-254580-nhpjvgt4 180 127 III iii CD cord-254580-nhpjvgt4 180 128 , , , cord-254580-nhpjvgt4 180 129 randomized randomized JJ cord-254580-nhpjvgt4 180 130 , , , cord-254580-nhpjvgt4 180 131 double double JJ cord-254580-nhpjvgt4 180 132 - - HYPH cord-254580-nhpjvgt4 180 133 blind blind JJ cord-254580-nhpjvgt4 180 134 , , , cord-254580-nhpjvgt4 180 135 placebo placebo NN cord-254580-nhpjvgt4 180 136 - - HYPH cord-254580-nhpjvgt4 180 137 controlled control VBN cord-254580-nhpjvgt4 180 138 study study NN cord-254580-nhpjvgt4 180 139 of of IN cord-254580-nhpjvgt4 180 140 brodalumab brodalumab NNP cord-254580-nhpjvgt4 180 141 in in IN cord-254580-nhpjvgt4 180 142 patients patient NNS cord-254580-nhpjvgt4 180 143 with with IN cord-254580-nhpjvgt4 180 144 moderate moderate JJ cord-254580-nhpjvgt4 180 145 - - HYPH cord-254580-nhpjvgt4 180 146 to to IN cord-254580-nhpjvgt4 180 147 - - HYPH cord-254580-nhpjvgt4 180 148 severe severe JJ cord-254580-nhpjvgt4 180 149 plaque plaque NN cord-254580-nhpjvgt4 180 150 psoriasis psoriasis NN