id sid tid token lemma pos cord-021424-kocwsyi7 1 1 key key JJ cord-021424-kocwsyi7 1 2 : : : cord-021424-kocwsyi7 1 3 cord-021424-kocwsyi7 cord-021424-kocwsyi7 NNP cord-021424-kocwsyi7 1 4 authors author NNS cord-021424-kocwsyi7 1 5 : : : cord-021424-kocwsyi7 1 6 Shannon Shannon NNP cord-021424-kocwsyi7 1 7 , , , cord-021424-kocwsyi7 1 8 M. M. NNP cord-021424-kocwsyi7 1 9 Frances Frances NNP cord-021424-kocwsyi7 1 10 title title NN cord-021424-kocwsyi7 1 11 : : : cord-021424-kocwsyi7 1 12 Genomic genomic JJ cord-021424-kocwsyi7 1 13 Approaches approach NNS cord-021424-kocwsyi7 1 14 to to IN cord-021424-kocwsyi7 1 15 the the DT cord-021424-kocwsyi7 1 16 Host Host NNP cord-021424-kocwsyi7 1 17 Response response NN cord-021424-kocwsyi7 1 18 to to IN cord-021424-kocwsyi7 1 19 Pathogens Pathogens NNP cord-021424-kocwsyi7 1 20 date date NN cord-021424-kocwsyi7 1 21 : : : cord-021424-kocwsyi7 1 22 2009 2009 CD cord-021424-kocwsyi7 1 23 - - SYM cord-021424-kocwsyi7 1 24 01 01 CD cord-021424-kocwsyi7 1 25 - - SYM cord-021424-kocwsyi7 1 26 30 30 CD cord-021424-kocwsyi7 1 27 journal journal NN cord-021424-kocwsyi7 1 28 : : : cord-021424-kocwsyi7 1 29 Genomic Genomic NNP cord-021424-kocwsyi7 1 30 and and CC cord-021424-kocwsyi7 1 31 Personalized Personalized NNP cord-021424-kocwsyi7 1 32 Medicine Medicine NNP cord-021424-kocwsyi7 1 33 DOI DOI NNP cord-021424-kocwsyi7 1 34 : : : cord-021424-kocwsyi7 1 35 10.1016 10.1016 CD cord-021424-kocwsyi7 1 36 / / SYM cord-021424-kocwsyi7 1 37 b978 b978 NN cord-021424-kocwsyi7 1 38 - - HYPH cord-021424-kocwsyi7 1 39 0 0 CD cord-021424-kocwsyi7 1 40 - - HYPH cord-021424-kocwsyi7 1 41 12 12 CD cord-021424-kocwsyi7 1 42 - - HYPH cord-021424-kocwsyi7 1 43 369420 369420 CD cord-021424-kocwsyi7 1 44 - - HYPH cord-021424-kocwsyi7 1 45 1.00107 1.00107 CD cord-021424-kocwsyi7 1 46 - - SYM cord-021424-kocwsyi7 1 47 4 4 CD cord-021424-kocwsyi7 1 48 sha sha NNP cord-021424-kocwsyi7 1 49 : : : cord-021424-kocwsyi7 1 50 09d15725f4cc7a235d14bebc49f396c36925530d 09d15725f4cc7a235d14bebc49f396c36925530d CD cord-021424-kocwsyi7 1 51 doc_id doc_id CD cord-021424-kocwsyi7 1 52 : : : cord-021424-kocwsyi7 1 53 21424 21424 CD cord-021424-kocwsyi7 1 54 cord_uid cord_uid NNS cord-021424-kocwsyi7 1 55 : : : cord-021424-kocwsyi7 1 56 kocwsyi7 kocwsyi7 NNP cord-021424-kocwsyi7 1 57 nan nan NNP cord-021424-kocwsyi7 2 1 Following follow VBG cord-021424-kocwsyi7 2 2 a a DT cord-021424-kocwsyi7 2 3 period period NN cord-021424-kocwsyi7 2 4 of of IN cord-021424-kocwsyi7 2 5 relative relative JJ cord-021424-kocwsyi7 2 6 disinterest disinterest NN cord-021424-kocwsyi7 2 7 in in IN cord-021424-kocwsyi7 2 8 infectious infectious JJ cord-021424-kocwsyi7 2 9 disease disease NN cord-021424-kocwsyi7 2 10 research research NN cord-021424-kocwsyi7 2 11 due due IN cord-021424-kocwsyi7 2 12 to to IN cord-021424-kocwsyi7 2 13 the the DT cord-021424-kocwsyi7 2 14 enormous enormous JJ cord-021424-kocwsyi7 2 15 impact impact NN cord-021424-kocwsyi7 2 16 of of IN cord-021424-kocwsyi7 2 17 vaccines vaccine NNS cord-021424-kocwsyi7 2 18 and and CC cord-021424-kocwsyi7 2 19 antibiotics antibiotic NNS cord-021424-kocwsyi7 2 20 on on IN cord-021424-kocwsyi7 2 21 the the DT cord-021424-kocwsyi7 2 22 spread spread NN cord-021424-kocwsyi7 2 23 of of IN cord-021424-kocwsyi7 2 24 and and CC cord-021424-kocwsyi7 2 25 mortality mortality NN cord-021424-kocwsyi7 2 26 from from IN cord-021424-kocwsyi7 2 27 these these DT cord-021424-kocwsyi7 2 28 diseases disease NNS cord-021424-kocwsyi7 2 29 , , , cord-021424-kocwsyi7 2 30 there there EX cord-021424-kocwsyi7 2 31 is be VBZ cord-021424-kocwsyi7 2 32 now now RB cord-021424-kocwsyi7 2 33 renewed renew VBN cord-021424-kocwsyi7 2 34 and and CC cord-021424-kocwsyi7 2 35 growing grow VBG cord-021424-kocwsyi7 2 36 interest interest NN cord-021424-kocwsyi7 2 37 in in IN cord-021424-kocwsyi7 2 38 this this DT cord-021424-kocwsyi7 2 39 area area NN cord-021424-kocwsyi7 2 40 of of IN cord-021424-kocwsyi7 2 41 research research NN cord-021424-kocwsyi7 2 42 . . . cord-021424-kocwsyi7 3 1 This this DT cord-021424-kocwsyi7 3 2 has have VBZ cord-021424-kocwsyi7 3 3 been be VBN cord-021424-kocwsyi7 3 4 driven drive VBN cord-021424-kocwsyi7 3 5 by by IN cord-021424-kocwsyi7 3 6 several several JJ cord-021424-kocwsyi7 3 7 recent recent JJ cord-021424-kocwsyi7 3 8 worldwide worldwide JJ cord-021424-kocwsyi7 3 9 developments development NNS cord-021424-kocwsyi7 3 10 including include VBG cord-021424-kocwsyi7 3 11 : : : cord-021424-kocwsyi7 3 12 ( ( -LRB- cord-021424-kocwsyi7 3 13 i i NN cord-021424-kocwsyi7 3 14 ) ) -RRB- cord-021424-kocwsyi7 4 1 the the DT cord-021424-kocwsyi7 4 2 rising rise VBG cord-021424-kocwsyi7 4 3 incidence incidence NN cord-021424-kocwsyi7 4 4 of of IN cord-021424-kocwsyi7 4 5 diseases disease NNS cord-021424-kocwsyi7 4 6 such such JJ cord-021424-kocwsyi7 4 7 as as IN cord-021424-kocwsyi7 4 8 Acquired Acquired NNP cord-021424-kocwsyi7 4 9 Immune Immune NNP cord-021424-kocwsyi7 4 10 Defi Defi NNP cord-021424-kocwsyi7 4 11 ciency ciency NN cord-021424-kocwsyi7 4 12 Syndrome syndrome NN cord-021424-kocwsyi7 4 13 ( ( -LRB- cord-021424-kocwsyi7 4 14 AIDS AIDS NNP cord-021424-kocwsyi7 4 15 ) ) -RRB- cord-021424-kocwsyi7 4 16 and and CC cord-021424-kocwsyi7 4 17 antibiotic antibiotic JJ cord-021424-kocwsyi7 4 18 - - HYPH cord-021424-kocwsyi7 4 19 resistant resistant JJ cord-021424-kocwsyi7 4 20 tuberculosis tuberculosis NN cord-021424-kocwsyi7 4 21 ; ; , cord-021424-kocwsyi7 4 22 ( ( -LRB- cord-021424-kocwsyi7 4 23 ii ii NN cord-021424-kocwsyi7 4 24 ) ) -RRB- cord-021424-kocwsyi7 4 25 antibiotic antibiotic JJ cord-021424-kocwsyi7 4 26 - - HYPH cord-021424-kocwsyi7 4 27 resistant resistant JJ cord-021424-kocwsyi7 4 28 bacterial bacterial JJ cord-021424-kocwsyi7 4 29 strains strain NNS cord-021424-kocwsyi7 4 30 presenting present VBG cord-021424-kocwsyi7 4 31 a a DT cord-021424-kocwsyi7 4 32 severe severe JJ cord-021424-kocwsyi7 4 33 health health NN cord-021424-kocwsyi7 4 34 threat threat NN cord-021424-kocwsyi7 4 35 in in IN cord-021424-kocwsyi7 4 36 hospitals hospital NNS cord-021424-kocwsyi7 4 37 ; ; , cord-021424-kocwsyi7 4 38 ( ( -LRB- cord-021424-kocwsyi7 4 39 iii iii NN cord-021424-kocwsyi7 4 40 ) ) -RRB- cord-021424-kocwsyi7 5 1 the the DT cord-021424-kocwsyi7 5 2 rapid rapid JJ cord-021424-kocwsyi7 5 3 spread spread NN cord-021424-kocwsyi7 5 4 of of IN cord-021424-kocwsyi7 5 5 new new JJ cord-021424-kocwsyi7 5 6 pathogens pathogen NNS cord-021424-kocwsyi7 5 7 such such JJ cord-021424-kocwsyi7 5 8 as as IN cord-021424-kocwsyi7 5 9 Severe severe JJ cord-021424-kocwsyi7 5 10 Acute acute JJ cord-021424-kocwsyi7 5 11 Respiratory Respiratory NNP cord-021424-kocwsyi7 5 12 Syndrome Syndrome NNP cord-021424-kocwsyi7 5 13 ( ( -LRB- cord-021424-kocwsyi7 5 14 SARS SARS NNP cord-021424-kocwsyi7 5 15 ) ) -RRB- cord-021424-kocwsyi7 5 16 ; ; : cord-021424-kocwsyi7 5 17 and and CC cord-021424-kocwsyi7 5 18 ( ( -LRB- cord-021424-kocwsyi7 5 19 iv iv LS cord-021424-kocwsyi7 5 20 ) ) -RRB- cord-021424-kocwsyi7 5 21 the the DT cord-021424-kocwsyi7 5 22 threat threat NN cord-021424-kocwsyi7 5 23 of of IN cord-021424-kocwsyi7 5 24 bioterrorism bioterrorism NN cord-021424-kocwsyi7 5 25 . . . cord-021424-kocwsyi7 6 1 Indeed indeed RB cord-021424-kocwsyi7 6 2 , , , cord-021424-kocwsyi7 6 3 nearly nearly RB cord-021424-kocwsyi7 6 4 25 25 CD cord-021424-kocwsyi7 6 5 % % NN cord-021424-kocwsyi7 6 6 of of IN cord-021424-kocwsyi7 6 7 annual annual JJ cord-021424-kocwsyi7 6 8 deaths death NNS cord-021424-kocwsyi7 6 9 worldwide worldwide RB cord-021424-kocwsyi7 6 10 are be VBP cord-021424-kocwsyi7 6 11 due due JJ cord-021424-kocwsyi7 6 12 to to IN cord-021424-kocwsyi7 6 13 infectious infectious JJ cord-021424-kocwsyi7 6 14 disease disease NN cord-021424-kocwsyi7 6 15 ( ( -LRB- cord-021424-kocwsyi7 6 16 Morens Morens NNP cord-021424-kocwsyi7 6 17 et et FW cord-021424-kocwsyi7 6 18 al al NNP cord-021424-kocwsyi7 6 19 . . NNP cord-021424-kocwsyi7 6 20 , , , cord-021424-kocwsyi7 6 21 2004 2004 CD cord-021424-kocwsyi7 6 22 ) ) -RRB- cord-021424-kocwsyi7 6 23 . . . cord-021424-kocwsyi7 7 1 Thus thus RB cord-021424-kocwsyi7 7 2 , , , cord-021424-kocwsyi7 7 3 the the DT cord-021424-kocwsyi7 7 4 need need NN cord-021424-kocwsyi7 7 5 to to TO cord-021424-kocwsyi7 7 6 develop develop VB cord-021424-kocwsyi7 7 7 new new JJ cord-021424-kocwsyi7 7 8 diagnostic diagnostic JJ cord-021424-kocwsyi7 7 9 methods method NNS cord-021424-kocwsyi7 7 10 , , , cord-021424-kocwsyi7 7 11 more more JJR cord-021424-kocwsyi7 7 12 effective effective JJ cord-021424-kocwsyi7 7 13 vaccines vaccine NNS cord-021424-kocwsyi7 7 14 and and CC cord-021424-kocwsyi7 7 15 better well JJR cord-021424-kocwsyi7 7 16 therapeutic therapeutic JJ cord-021424-kocwsyi7 7 17 strategies strategy NNS cord-021424-kocwsyi7 7 18 is be VBZ cord-021424-kocwsyi7 7 19 urgent urgent JJ cord-021424-kocwsyi7 7 20 . . . cord-021424-kocwsyi7 8 1 In in IN cord-021424-kocwsyi7 8 2 order order NN cord-021424-kocwsyi7 8 3 to to TO cord-021424-kocwsyi7 8 4 effectively effectively RB cord-021424-kocwsyi7 8 5 deal deal VB cord-021424-kocwsyi7 8 6 with with IN cord-021424-kocwsyi7 8 7 infectious infectious JJ cord-021424-kocwsyi7 8 8 disease disease NN cord-021424-kocwsyi7 8 9 threats threat NNS cord-021424-kocwsyi7 8 10 , , , cord-021424-kocwsyi7 8 11 it -PRON- PRP cord-021424-kocwsyi7 8 12 is be VBZ cord-021424-kocwsyi7 8 13 important important JJ cord-021424-kocwsyi7 8 14 to to TO cord-021424-kocwsyi7 8 15 understand understand VB cord-021424-kocwsyi7 8 16 both both CC cord-021424-kocwsyi7 8 17 the the DT cord-021424-kocwsyi7 8 18 pathogen pathogen NN cord-021424-kocwsyi7 8 19 and and CC cord-021424-kocwsyi7 8 20 the the DT cord-021424-kocwsyi7 8 21 response response NN cord-021424-kocwsyi7 8 22 of of IN cord-021424-kocwsyi7 8 23 the the DT cord-021424-kocwsyi7 8 24 host host NN cord-021424-kocwsyi7 8 25 , , , cord-021424-kocwsyi7 8 26 since since IN cord-021424-kocwsyi7 8 27 the the DT cord-021424-kocwsyi7 8 28 outcome outcome NN cord-021424-kocwsyi7 8 29 of of IN cord-021424-kocwsyi7 8 30 infection infection NN cord-021424-kocwsyi7 8 31 is be VBZ cord-021424-kocwsyi7 8 32 determined determine VBN cord-021424-kocwsyi7 8 33 by by IN cord-021424-kocwsyi7 8 34 complex complex JJ cord-021424-kocwsyi7 8 35 host host NN cord-021424-kocwsyi7 8 36 - - HYPH cord-021424-kocwsyi7 8 37 pathogen pathogen NN cord-021424-kocwsyi7 8 38 interactions interaction NNS cord-021424-kocwsyi7 8 39 . . . cord-021424-kocwsyi7 9 1 Pathogens pathogen NNS cord-021424-kocwsyi7 9 2 are be VBP cord-021424-kocwsyi7 9 3 initially initially RB cord-021424-kocwsyi7 9 4 detected detect VBN cord-021424-kocwsyi7 9 5 by by IN cord-021424-kocwsyi7 9 6 the the DT cord-021424-kocwsyi7 9 7 surveillance surveillance NN cord-021424-kocwsyi7 9 8 cells cell NNS cord-021424-kocwsyi7 9 9 of of IN cord-021424-kocwsyi7 9 10 the the DT cord-021424-kocwsyi7 9 11 innate innate JJ cord-021424-kocwsyi7 9 12 immune immune JJ cord-021424-kocwsyi7 9 13 system system NN cord-021424-kocwsyi7 9 14 using use VBG cord-021424-kocwsyi7 9 15 cell cell NN cord-021424-kocwsyi7 9 16 surface surface NN cord-021424-kocwsyi7 9 17 receptors receptor NNS cord-021424-kocwsyi7 9 18 known know VBN cord-021424-kocwsyi7 9 19 as as IN cord-021424-kocwsyi7 9 20 Toll Toll NNP cord-021424-kocwsyi7 9 21 - - HYPH cord-021424-kocwsyi7 9 22 like like JJ cord-021424-kocwsyi7 9 23 receptors receptor NNS cord-021424-kocwsyi7 9 24 ( ( -LRB- cord-021424-kocwsyi7 9 25 TLRs TLRs NNP cord-021424-kocwsyi7 9 26 ) ) -RRB- cord-021424-kocwsyi7 9 27 ( ( -LRB- cord-021424-kocwsyi7 9 28 reviewed review VBN cord-021424-kocwsyi7 9 29 in in IN cord-021424-kocwsyi7 9 30 ) ) -RRB- cord-021424-kocwsyi7 9 31 . . . cord-021424-kocwsyi7 10 1 These these DT cord-021424-kocwsyi7 10 2 TLRs tlr NNS cord-021424-kocwsyi7 10 3 recognize recognize VBP cord-021424-kocwsyi7 10 4 specifi specifi NNP cord-021424-kocwsyi7 10 5 c c NN cord-021424-kocwsyi7 10 6 components component NNS cord-021424-kocwsyi7 10 7 of of IN cord-021424-kocwsyi7 10 8 the the DT cord-021424-kocwsyi7 10 9 pathogen pathogen NN cord-021424-kocwsyi7 10 10 , , , cord-021424-kocwsyi7 10 11 for for IN cord-021424-kocwsyi7 10 12 example example NN cord-021424-kocwsyi7 10 13 , , , cord-021424-kocwsyi7 10 14 bacterial bacterial JJ cord-021424-kocwsyi7 10 15 lipopolysaccharide lipopolysaccharide NN cord-021424-kocwsyi7 10 16 ( ( -LRB- cord-021424-kocwsyi7 10 17 LPS LPS NNP cord-021424-kocwsyi7 10 18 ) ) -RRB- cord-021424-kocwsyi7 10 19 or or CC cord-021424-kocwsyi7 10 20 double double RB cord-021424-kocwsyi7 10 21 - - HYPH cord-021424-kocwsyi7 10 22 stranded stranded JJ cord-021424-kocwsyi7 10 23 ( ( -LRB- cord-021424-kocwsyi7 10 24 ds ds NNP cord-021424-kocwsyi7 10 25 ) ) -RRB- cord-021424-kocwsyi7 10 26 RNA RNA NNP cord-021424-kocwsyi7 10 27 from from IN cord-021424-kocwsyi7 10 28 viruses virus NNS cord-021424-kocwsyi7 10 29 . . . cord-021424-kocwsyi7 11 1 While while IN cord-021424-kocwsyi7 11 2 many many JJ cord-021424-kocwsyi7 11 3 cell cell NN cord-021424-kocwsyi7 11 4 types type NNS cord-021424-kocwsyi7 11 5 express express VBP cord-021424-kocwsyi7 11 6 TLRs TLRs NNP cord-021424-kocwsyi7 11 7 , , , cord-021424-kocwsyi7 11 8 cells cell NNS cord-021424-kocwsyi7 11 9 of of IN cord-021424-kocwsyi7 11 10 the the DT cord-021424-kocwsyi7 11 11 innate innate JJ cord-021424-kocwsyi7 11 12 immune immune JJ cord-021424-kocwsyi7 11 13 system system NN cord-021424-kocwsyi7 11 14 such such JJ cord-021424-kocwsyi7 11 15 as as IN cord-021424-kocwsyi7 11 16 dendritic dendritic JJ cord-021424-kocwsyi7 11 17 cells cell NNS cord-021424-kocwsyi7 11 18 ( ( -LRB- cord-021424-kocwsyi7 11 19 DCs DCs NNP cord-021424-kocwsyi7 11 20 ) ) -RRB- cord-021424-kocwsyi7 11 21 and and CC cord-021424-kocwsyi7 11 22 macrophages macrophage NNS cord-021424-kocwsyi7 11 23 play play VBP cord-021424-kocwsyi7 11 24 particularly particularly RB cord-021424-kocwsyi7 11 25 important important JJ cord-021424-kocwsyi7 11 26 roles role NNS cord-021424-kocwsyi7 11 27 in in IN cord-021424-kocwsyi7 11 28 detecting detect VBG cord-021424-kocwsyi7 11 29 and and CC cord-021424-kocwsyi7 11 30 responding respond VBG cord-021424-kocwsyi7 11 31 to to IN cord-021424-kocwsyi7 11 32 pathogens pathogen NNS cord-021424-kocwsyi7 11 33 . . . cord-021424-kocwsyi7 12 1 The the DT cord-021424-kocwsyi7 12 2 response response NN cord-021424-kocwsyi7 12 3 of of IN cord-021424-kocwsyi7 12 4 these these DT cord-021424-kocwsyi7 12 5 cells cell NNS cord-021424-kocwsyi7 12 6 to to IN cord-021424-kocwsyi7 12 7 a a DT cord-021424-kocwsyi7 12 8 pathogen pathogen NN cord-021424-kocwsyi7 12 9 is be VBZ cord-021424-kocwsyi7 12 10 determined determine VBN cord-021424-kocwsyi7 12 11 by by IN cord-021424-kocwsyi7 12 12 the the DT cord-021424-kocwsyi7 12 13 specifi specifi NNP cord-021424-kocwsyi7 12 14 c c NNP cord-021424-kocwsyi7 12 15 pathogen pathogen NN cord-021424-kocwsyi7 12 16 component component NN cord-021424-kocwsyi7 12 17 that that WDT cord-021424-kocwsyi7 12 18 interacts interact VBZ cord-021424-kocwsyi7 12 19 with with IN cord-021424-kocwsyi7 12 20 the the DT cord-021424-kocwsyi7 12 21 TLR TLR NNP cord-021424-kocwsyi7 12 22 and and CC cord-021424-kocwsyi7 12 23 the the DT cord-021424-kocwsyi7 12 24 specifi specifi NN cord-021424-kocwsyi7 12 25 c c NN cord-021424-kocwsyi7 12 26 TLR TLR NNP cord-021424-kocwsyi7 12 27 family family NN cord-021424-kocwsyi7 12 28 member member NN cord-021424-kocwsyi7 12 29 that that WDT cord-021424-kocwsyi7 12 30 is be VBZ cord-021424-kocwsyi7 12 31 activated activate VBN cord-021424-kocwsyi7 12 32 . . . cord-021424-kocwsyi7 13 1 Widespread widespread JJ cord-021424-kocwsyi7 13 2 changes change NNS cord-021424-kocwsyi7 13 3 in in IN cord-021424-kocwsyi7 13 4 gene gene NN cord-021424-kocwsyi7 13 5 expression expression NN cord-021424-kocwsyi7 13 6 are be VBP cord-021424-kocwsyi7 13 7 detected detect VBN cord-021424-kocwsyi7 13 8 following follow VBG cord-021424-kocwsyi7 13 9 TLR TLR NNP cord-021424-kocwsyi7 13 10 activation activation NN cord-021424-kocwsyi7 13 11 and and CC cord-021424-kocwsyi7 13 12 the the DT cord-021424-kocwsyi7 13 13 activated activate VBN cord-021424-kocwsyi7 13 14 cells cell NNS cord-021424-kocwsyi7 13 15 produce produce VBP cord-021424-kocwsyi7 13 16 a a DT cord-021424-kocwsyi7 13 17 plethora plethora NN cord-021424-kocwsyi7 13 18 of of IN cord-021424-kocwsyi7 13 19 cytokines cytokine NNS cord-021424-kocwsyi7 13 20 and and CC cord-021424-kocwsyi7 13 21 chemokines chemokine NNS cord-021424-kocwsyi7 13 22 that that WDT cord-021424-kocwsyi7 13 23 then then RB cord-021424-kocwsyi7 13 24 activate activate VBP cord-021424-kocwsyi7 13 25 the the DT cord-021424-kocwsyi7 13 26 adaptive adaptive JJ cord-021424-kocwsyi7 13 27 arm arm NN cord-021424-kocwsyi7 13 28 of of IN cord-021424-kocwsyi7 13 29 the the DT cord-021424-kocwsyi7 13 30 immune immune JJ cord-021424-kocwsyi7 13 31 system system NN cord-021424-kocwsyi7 13 32 . . . cord-021424-kocwsyi7 14 1 The the DT cord-021424-kocwsyi7 14 2 specifi specifi NN cord-021424-kocwsyi7 14 3 c c NN cord-021424-kocwsyi7 14 4 cytokines cytokine NNS cord-021424-kocwsyi7 14 5 and and CC cord-021424-kocwsyi7 14 6 chemokines chemokine NNS cord-021424-kocwsyi7 14 7 produced produce VBN cord-021424-kocwsyi7 14 8 by by IN cord-021424-kocwsyi7 14 9 the the DT cord-021424-kocwsyi7 14 10 TLR TLR NNP cord-021424-kocwsyi7 14 11 - - HYPH cord-021424-kocwsyi7 14 12 activated activate VBN cord-021424-kocwsyi7 14 13 cells cell NNS cord-021424-kocwsyi7 14 14 tailor tailor VBP cord-021424-kocwsyi7 14 15 the the DT cord-021424-kocwsyi7 14 16 response response NN cord-021424-kocwsyi7 14 17 of of IN cord-021424-kocwsyi7 14 18 the the DT cord-021424-kocwsyi7 14 19 adaptive adaptive JJ cord-021424-kocwsyi7 14 20 immune immune JJ cord-021424-kocwsyi7 14 21 system system NN cord-021424-kocwsyi7 14 22 to to TO cord-021424-kocwsyi7 14 23 deal deal VB cord-021424-kocwsyi7 14 24 with with IN cord-021424-kocwsyi7 14 25 the the DT cord-021424-kocwsyi7 14 26 specifi specifi NNP cord-021424-kocwsyi7 14 27 c c NN cord-021424-kocwsyi7 14 28 pathogen pathogen NN cord-021424-kocwsyi7 14 29 . . . cord-021424-kocwsyi7 15 1 Thus thus RB cord-021424-kocwsyi7 15 2 , , , cord-021424-kocwsyi7 15 3 the the DT cord-021424-kocwsyi7 15 4 initial initial JJ cord-021424-kocwsyi7 15 5 host host NN cord-021424-kocwsyi7 15 6 response response NN cord-021424-kocwsyi7 15 7 to to IN cord-021424-kocwsyi7 15 8 a a DT cord-021424-kocwsyi7 15 9 pathogen pathogen NN cord-021424-kocwsyi7 15 10 through through IN cord-021424-kocwsyi7 15 11 the the DT cord-021424-kocwsyi7 15 12 TLRs TLRs NNP cord-021424-kocwsyi7 15 13 determines determine VBZ cord-021424-kocwsyi7 15 14 the the DT cord-021424-kocwsyi7 15 15 outcome outcome NN cord-021424-kocwsyi7 15 16 of of IN cord-021424-kocwsyi7 15 17 the the DT cord-021424-kocwsyi7 15 18 infection infection NN cord-021424-kocwsyi7 15 19 . . . cord-021424-kocwsyi7 16 1 Host host NN cord-021424-kocwsyi7 16 2 response response NN cord-021424-kocwsyi7 16 3 to to IN cord-021424-kocwsyi7 16 4 infection infection NN cord-021424-kocwsyi7 16 5 can can MD cord-021424-kocwsyi7 16 6 be be VB cord-021424-kocwsyi7 16 7 a a DT cord-021424-kocwsyi7 16 8 double double RB cord-021424-kocwsyi7 16 9 - - HYPH cord-021424-kocwsyi7 16 10 edged edged JJ cord-021424-kocwsyi7 16 11 sword sword NN cord-021424-kocwsyi7 16 12 in in IN cord-021424-kocwsyi7 16 13 that that DT cord-021424-kocwsyi7 17 1 sometimes sometimes RB cord-021424-kocwsyi7 17 2 the the DT cord-021424-kocwsyi7 17 3 response response NN cord-021424-kocwsyi7 17 4 itself -PRON- PRP cord-021424-kocwsyi7 17 5 can can MD cord-021424-kocwsyi7 17 6 create create VB cord-021424-kocwsyi7 17 7 an an DT cord-021424-kocwsyi7 17 8 adverse adverse JJ cord-021424-kocwsyi7 17 9 outcome outcome NN cord-021424-kocwsyi7 17 10 for for IN cord-021424-kocwsyi7 17 11 the the DT cord-021424-kocwsyi7 17 12 host host NN cord-021424-kocwsyi7 17 13 . . . cord-021424-kocwsyi7 18 1 In in IN cord-021424-kocwsyi7 18 2 addition addition NN cord-021424-kocwsyi7 18 3 , , , cord-021424-kocwsyi7 18 4 the the DT cord-021424-kocwsyi7 18 5 aberrant aberrant JJ cord-021424-kocwsyi7 18 6 response response NN cord-021424-kocwsyi7 18 7 of of IN cord-021424-kocwsyi7 18 8 the the DT cord-021424-kocwsyi7 18 9 host host NN cord-021424-kocwsyi7 18 10 to to IN cord-021424-kocwsyi7 18 11 self self NN cord-021424-kocwsyi7 18 12 instead instead RB cord-021424-kocwsyi7 18 13 of of IN cord-021424-kocwsyi7 18 14 foreign foreign JJ cord-021424-kocwsyi7 18 15 pathogens pathogen NNS cord-021424-kocwsyi7 18 16 can can MD cord-021424-kocwsyi7 18 17 create create VB cord-021424-kocwsyi7 18 18 severe severe JJ cord-021424-kocwsyi7 18 19 pathologies pathology NNS cord-021424-kocwsyi7 18 20 involving involve VBG cord-021424-kocwsyi7 18 21 chronic chronic JJ cord-021424-kocwsyi7 18 22 infl infl NNP cord-021424-kocwsyi7 18 23 ammatory ammatory NN cord-021424-kocwsyi7 18 24 and and CC cord-021424-kocwsyi7 18 25 autoimmune autoimmune JJ cord-021424-kocwsyi7 18 26 diseases disease NNS cord-021424-kocwsyi7 18 27 . . . cord-021424-kocwsyi7 19 1 The the DT cord-021424-kocwsyi7 19 2 urgent urgent JJ cord-021424-kocwsyi7 19 3 need need NN cord-021424-kocwsyi7 19 4 to to TO cord-021424-kocwsyi7 19 5 better better RB cord-021424-kocwsyi7 19 6 understand understand VB cord-021424-kocwsyi7 19 7 host host NN cord-021424-kocwsyi7 19 8 - - HYPH cord-021424-kocwsyi7 19 9 pathogen pathogen NN cord-021424-kocwsyi7 19 10 interactions interaction NNS cord-021424-kocwsyi7 19 11 has have VBZ cord-021424-kocwsyi7 19 12 come come VBN cord-021424-kocwsyi7 19 13 at at IN cord-021424-kocwsyi7 19 14 a a DT cord-021424-kocwsyi7 19 15 time time NN cord-021424-kocwsyi7 19 16 when when WRB cord-021424-kocwsyi7 19 17 genomics genomic NNS cord-021424-kocwsyi7 19 18 and and CC cord-021424-kocwsyi7 19 19 related related JJ cord-021424-kocwsyi7 19 20 technologies technology NNS cord-021424-kocwsyi7 19 21 are be VBP cord-021424-kocwsyi7 19 22 expanding expand VBG cord-021424-kocwsyi7 19 23 rapidly rapidly RB cord-021424-kocwsyi7 19 24 . . . cord-021424-kocwsyi7 20 1 The the DT cord-021424-kocwsyi7 20 2 availability availability NN cord-021424-kocwsyi7 20 3 of of IN cord-021424-kocwsyi7 20 4 complete complete JJ cord-021424-kocwsyi7 20 5 genomic genomic JJ cord-021424-kocwsyi7 20 6 sequences sequence NNS cord-021424-kocwsyi7 20 7 of of IN cord-021424-kocwsyi7 20 8 an an DT cord-021424-kocwsyi7 20 9 expanding expand VBG cord-021424-kocwsyi7 20 10 number number NN cord-021424-kocwsyi7 20 11 of of IN cord-021424-kocwsyi7 20 12 pathogens pathogen NNS cord-021424-kocwsyi7 20 13 , , , cord-021424-kocwsyi7 20 14 the the DT cord-021424-kocwsyi7 20 15 human human NN cord-021424-kocwsyi7 20 16 and and CC cord-021424-kocwsyi7 20 17 mouse mouse NN cord-021424-kocwsyi7 20 18 genome genome NN cord-021424-kocwsyi7 20 19 sequences sequence NNS cord-021424-kocwsyi7 20 20 and and CC cord-021424-kocwsyi7 20 21 the the DT cord-021424-kocwsyi7 20 22 advent advent NN cord-021424-kocwsyi7 20 23 of of IN cord-021424-kocwsyi7 20 24 genome genome NN cord-021424-kocwsyi7 20 25 - - HYPH cord-021424-kocwsyi7 20 26 wide wide JJ cord-021424-kocwsyi7 20 27 genotyping genotyping NN cord-021424-kocwsyi7 20 28 and and CC cord-021424-kocwsyi7 20 29 gene gene NN cord-021424-kocwsyi7 20 30 expression expression NN cord-021424-kocwsyi7 20 31 profi profi NNP cord-021424-kocwsyi7 20 32 ling ling NNP cord-021424-kocwsyi7 20 33 has have VBZ cord-021424-kocwsyi7 20 34 opened open VBN cord-021424-kocwsyi7 20 35 up up RP cord-021424-kocwsyi7 20 36 new new JJ cord-021424-kocwsyi7 20 37 avenues avenue NNS cord-021424-kocwsyi7 20 38 of of IN cord-021424-kocwsyi7 20 39 investigation investigation NN cord-021424-kocwsyi7 20 40 in in IN cord-021424-kocwsyi7 20 41 the the DT cord-021424-kocwsyi7 20 42 fi fi NNP cord-021424-kocwsyi7 20 43 eld eld NN cord-021424-kocwsyi7 20 44 . . . cord-021424-kocwsyi7 21 1 The the DT cord-021424-kocwsyi7 21 2 genotype genotype NN cord-021424-kocwsyi7 21 3 of of IN cord-021424-kocwsyi7 21 4 the the DT cord-021424-kocwsyi7 21 5 pathogen pathogen NN cord-021424-kocwsyi7 21 6 plays play VBZ cord-021424-kocwsyi7 21 7 a a DT cord-021424-kocwsyi7 21 8 major major JJ cord-021424-kocwsyi7 21 9 role role NN cord-021424-kocwsyi7 21 10 in in IN cord-021424-kocwsyi7 21 11 the the DT cord-021424-kocwsyi7 21 12 response response NN cord-021424-kocwsyi7 21 13 of of IN cord-021424-kocwsyi7 21 14 the the DT cord-021424-kocwsyi7 21 15 host host NN cord-021424-kocwsyi7 21 16 to to IN cord-021424-kocwsyi7 21 17 infection infection NN cord-021424-kocwsyi7 21 18 with with IN cord-021424-kocwsyi7 21 19 more more RBR cord-021424-kocwsyi7 21 20 virulent virulent JJ cord-021424-kocwsyi7 21 21 pathogenic pathogenic JJ cord-021424-kocwsyi7 21 22 strains strain NNS cord-021424-kocwsyi7 21 23 often often RB cord-021424-kocwsyi7 21 24 possessing possess VBG cord-021424-kocwsyi7 21 25 the the DT cord-021424-kocwsyi7 21 26 capability capability NN cord-021424-kocwsyi7 21 27 to to TO cord-021424-kocwsyi7 21 28 interfere interfere VB cord-021424-kocwsyi7 21 29 with with IN cord-021424-kocwsyi7 21 30 the the DT cord-021424-kocwsyi7 21 31 host host NN cord-021424-kocwsyi7 21 32 immune immune JJ cord-021424-kocwsyi7 21 33 response response NN cord-021424-kocwsyi7 21 34 ( ( -LRB- cord-021424-kocwsyi7 21 35 Fitzgerald Fitzgerald NNP cord-021424-kocwsyi7 21 36 and and CC cord-021424-kocwsyi7 21 37 Musser Musser NNP cord-021424-kocwsyi7 21 38 , , , cord-021424-kocwsyi7 21 39 2001 2001 CD cord-021424-kocwsyi7 21 40 ; ; : cord-021424-kocwsyi7 22 1 Kato Kato NNP cord-021424-kocwsyi7 22 2 - - HYPH cord-021424-kocwsyi7 22 3 Maeda Maeda NNP cord-021424-kocwsyi7 22 4 et et NNP cord-021424-kocwsyi7 22 5 al al NNP cord-021424-kocwsyi7 22 6 . . NNP cord-021424-kocwsyi7 22 7 , , , cord-021424-kocwsyi7 22 8 2001 2001 CD cord-021424-kocwsyi7 23 1 ; ; : cord-021424-kocwsyi7 23 2 Schoolnik Schoolnik NNP cord-021424-kocwsyi7 23 3 , , , cord-021424-kocwsyi7 23 4 2002 2002 CD cord-021424-kocwsyi7 23 5 ) ) -RRB- cord-021424-kocwsyi7 23 6 . . . cord-021424-kocwsyi7 24 1 In in IN cord-021424-kocwsyi7 24 2 addition addition NN cord-021424-kocwsyi7 24 3 , , , cord-021424-kocwsyi7 24 4 different different JJ cord-021424-kocwsyi7 24 5 individuals individual NNS cord-021424-kocwsyi7 24 6 in in IN cord-021424-kocwsyi7 24 7 a a DT cord-021424-kocwsyi7 24 8 population population NN cord-021424-kocwsyi7 24 9 can can MD cord-021424-kocwsyi7 24 10 have have VB cord-021424-kocwsyi7 24 11 very very RB cord-021424-kocwsyi7 24 12 different different JJ cord-021424-kocwsyi7 24 13 responses response NNS cord-021424-kocwsyi7 24 14 to to IN cord-021424-kocwsyi7 24 15 a a DT cord-021424-kocwsyi7 24 16 genetically genetically RB cord-021424-kocwsyi7 24 17 identical identical JJ cord-021424-kocwsyi7 24 18 pathogen pathogen NN cord-021424-kocwsyi7 24 19 . . . cord-021424-kocwsyi7 25 1 While while IN cord-021424-kocwsyi7 25 2 there there EX cord-021424-kocwsyi7 25 3 are be VBP cord-021424-kocwsyi7 25 4 many many JJ cord-021424-kocwsyi7 25 5 complex complex JJ cord-021424-kocwsyi7 25 6 reasons reason NNS cord-021424-kocwsyi7 25 7 for for IN cord-021424-kocwsyi7 25 8 this this DT cord-021424-kocwsyi7 25 9 , , , cord-021424-kocwsyi7 25 10 it -PRON- PRP cord-021424-kocwsyi7 25 11 is be VBZ cord-021424-kocwsyi7 25 12 clear clear JJ cord-021424-kocwsyi7 25 13 that that IN cord-021424-kocwsyi7 25 14 part part NN cord-021424-kocwsyi7 25 15 of of IN cord-021424-kocwsyi7 25 16 the the DT cord-021424-kocwsyi7 25 17 differential differential JJ cord-021424-kocwsyi7 25 18 response response NN cord-021424-kocwsyi7 25 19 is be VBZ cord-021424-kocwsyi7 25 20 governed govern VBN cord-021424-kocwsyi7 25 21 by by IN cord-021424-kocwsyi7 25 22 underlying underlie VBG cord-021424-kocwsyi7 25 23 genetic genetic JJ cord-021424-kocwsyi7 25 24 differences difference NNS cord-021424-kocwsyi7 25 25 between between IN cord-021424-kocwsyi7 25 26 individuals individual NNS cord-021424-kocwsyi7 25 27 ( ( -LRB- cord-021424-kocwsyi7 25 28 Clementi Clementi NNP cord-021424-kocwsyi7 25 29 and and CC cord-021424-kocwsyi7 25 30 Di Di NNP cord-021424-kocwsyi7 25 31 Gianantonio Gianantonio NNP cord-021424-kocwsyi7 25 32 , , , cord-021424-kocwsyi7 25 33 2006 2006 CD cord-021424-kocwsyi7 25 34 ; ; : cord-021424-kocwsyi7 25 35 Zhang Zhang NNP cord-021424-kocwsyi7 25 36 and and CC cord-021424-kocwsyi7 25 37 Zhang Zhang NNP cord-021424-kocwsyi7 25 38 , , , cord-021424-kocwsyi7 25 39 2006 2006 CD cord-021424-kocwsyi7 25 40 ) ) -RRB- cord-021424-kocwsyi7 25 41 . . . cord-021424-kocwsyi7 26 1 Studies study NNS cord-021424-kocwsyi7 26 2 in in IN cord-021424-kocwsyi7 26 3 mouse mouse NN cord-021424-kocwsyi7 26 4 models model NNS cord-021424-kocwsyi7 26 5 of of IN cord-021424-kocwsyi7 26 6 infection infection NN cord-021424-kocwsyi7 26 7 have have VBP cord-021424-kocwsyi7 26 8 clearly clearly RB cord-021424-kocwsyi7 26 9 demonstrated demonstrate VBN cord-021424-kocwsyi7 26 10 that that IN cord-021424-kocwsyi7 26 11 these these DT cord-021424-kocwsyi7 26 12 genetic genetic JJ cord-021424-kocwsyi7 26 13 differences difference NNS cord-021424-kocwsyi7 26 14 are be VBP cord-021424-kocwsyi7 26 15 complex complex JJ cord-021424-kocwsyi7 26 16 and and CC cord-021424-kocwsyi7 26 17 may may MD cord-021424-kocwsyi7 26 18 involve involve VB cord-021424-kocwsyi7 26 19 more more JJR cord-021424-kocwsyi7 26 20 than than IN cord-021424-kocwsyi7 26 21 one one CD cord-021424-kocwsyi7 26 22 genetic genetic JJ cord-021424-kocwsyi7 26 23 locus locus NN cord-021424-kocwsyi7 26 24 for for IN cord-021424-kocwsyi7 26 25 a a DT cord-021424-kocwsyi7 26 26 given give VBN cord-021424-kocwsyi7 26 27 susceptibility susceptibility NN cord-021424-kocwsyi7 26 28 or or CC cord-021424-kocwsyi7 26 29 resistance resistance NN cord-021424-kocwsyi7 26 30 trait trait NN cord-021424-kocwsyi7 27 1 ( ( -LRB- cord-021424-kocwsyi7 27 2 e.g. e.g. RB cord-021424-kocwsyi7 27 3 , , , cord-021424-kocwsyi7 27 4 [ [ -LRB- cord-021424-kocwsyi7 27 5 Delahaye Delahaye NNP cord-021424-kocwsyi7 27 6 et et NNP cord-021424-kocwsyi7 27 7 al al NNP cord-021424-kocwsyi7 27 8 . . NNP cord-021424-kocwsyi7 27 9 , , , cord-021424-kocwsyi7 27 10 2006 2006 CD cord-021424-kocwsyi7 27 11 ] ] -RRB- cord-021424-kocwsyi7 27 12 ) ) -RRB- cord-021424-kocwsyi7 27 13 . . . cord-021424-kocwsyi7 28 1 While while IN cord-021424-kocwsyi7 28 2 there there EX cord-021424-kocwsyi7 28 3 are be VBP cord-021424-kocwsyi7 28 4 some some DT cord-021424-kocwsyi7 28 5 classic classic JJ cord-021424-kocwsyi7 28 6 examples example NNS cord-021424-kocwsyi7 28 7 of of IN cord-021424-kocwsyi7 28 8 genetic genetic JJ cord-021424-kocwsyi7 28 9 mutations mutation NNS cord-021424-kocwsyi7 28 10 affecting affect VBG cord-021424-kocwsyi7 28 11 the the DT cord-021424-kocwsyi7 28 12 response response NN cord-021424-kocwsyi7 28 13 of of IN cord-021424-kocwsyi7 28 14 the the DT cord-021424-kocwsyi7 28 15 host host NN cord-021424-kocwsyi7 28 16 to to IN cord-021424-kocwsyi7 28 17 a a DT cord-021424-kocwsyi7 28 18 pathogen pathogen NN cord-021424-kocwsyi7 28 19 ( ( -LRB- cord-021424-kocwsyi7 28 20 e.g. e.g. RB cord-021424-kocwsyi7 28 21 , , , cord-021424-kocwsyi7 28 22 malaria malaria NN cord-021424-kocwsyi7 28 23 and and CC cord-021424-kocwsyi7 28 24 sickle sickle NN cord-021424-kocwsyi7 28 25 cell cell NN cord-021424-kocwsyi7 28 26 mutations mutation NNS cord-021424-kocwsyi7 28 27 ) ) -RRB- cord-021424-kocwsyi7 28 28 there there EX cord-021424-kocwsyi7 28 29 is be VBZ cord-021424-kocwsyi7 28 30 much much JJ cord-021424-kocwsyi7 28 31 to to TO cord-021424-kocwsyi7 28 32 be be VB cord-021424-kocwsyi7 28 33 learned learn VBN cord-021424-kocwsyi7 28 34 before before IN cord-021424-kocwsyi7 28 35 the the DT cord-021424-kocwsyi7 28 36 genetics genetic NNS cord-021424-kocwsyi7 28 37 of of IN cord-021424-kocwsyi7 28 38 host host NN cord-021424-kocwsyi7 28 39 susceptibility susceptibility NN cord-021424-kocwsyi7 28 40 is be VBZ cord-021424-kocwsyi7 28 41 fully fully RB cord-021424-kocwsyi7 28 42 understood understand VBN cord-021424-kocwsyi7 28 43 . . . cord-021424-kocwsyi7 29 1 The the DT cord-021424-kocwsyi7 29 2 advent advent NN cord-021424-kocwsyi7 29 3 of of IN cord-021424-kocwsyi7 29 4 genome genome NN cord-021424-kocwsyi7 29 5 - - HYPH cord-021424-kocwsyi7 29 6 wide wide JJ cord-021424-kocwsyi7 29 7 genotyping genotyping NN cord-021424-kocwsyi7 29 8 using use VBG cord-021424-kocwsyi7 29 9 single single JJ cord-021424-kocwsyi7 29 10 nucleotide nucleotide JJ cord-021424-kocwsyi7 29 11 polymorphisms polymorphism NNS cord-021424-kocwsyi7 29 12 ( ( -LRB- cord-021424-kocwsyi7 29 13 SNPs SNPs NNP cord-021424-kocwsyi7 29 14 ) ) -RRB- cord-021424-kocwsyi7 29 15 or or CC cord-021424-kocwsyi7 29 16 microsatellite microsatellite JJ cord-021424-kocwsyi7 29 17 markers marker NNS cord-021424-kocwsyi7 29 18 , , , cord-021424-kocwsyi7 29 19 leading lead VBG cord-021424-kocwsyi7 29 20 to to IN cord-021424-kocwsyi7 29 21 major major JJ cord-021424-kocwsyi7 29 22 advances advance NNS cord-021424-kocwsyi7 29 23 in in IN cord-021424-kocwsyi7 29 24 molecular molecular JJ cord-021424-kocwsyi7 29 25 epidemiology epidemiology NN cord-021424-kocwsyi7 29 26 , , , cord-021424-kocwsyi7 29 27 will will MD cord-021424-kocwsyi7 29 28 revolutionize revolutionize VB cord-021424-kocwsyi7 29 29 our -PRON- PRP$ cord-021424-kocwsyi7 29 30 ability ability NN cord-021424-kocwsyi7 29 31 to to TO cord-021424-kocwsyi7 29 32 determine determine VB cord-021424-kocwsyi7 29 33 the the DT cord-021424-kocwsyi7 29 34 complexities complexity NNS cord-021424-kocwsyi7 29 35 of of IN cord-021424-kocwsyi7 29 36 the the DT cord-021424-kocwsyi7 29 37 genetic genetic JJ cord-021424-kocwsyi7 29 38 component component NN cord-021424-kocwsyi7 29 39 of of IN cord-021424-kocwsyi7 29 40 pathogen pathogen NN cord-021424-kocwsyi7 29 41 - - HYPH cord-021424-kocwsyi7 29 42 host host NN cord-021424-kocwsyi7 29 43 interactions interaction NNS cord-021424-kocwsyi7 29 44 ( ( -LRB- cord-021424-kocwsyi7 29 45 Weiss Weiss NNP cord-021424-kocwsyi7 29 46 and and CC cord-021424-kocwsyi7 29 47 Terwilliger Terwilliger NNP cord-021424-kocwsyi7 29 48 , , , cord-021424-kocwsyi7 29 49 2000 2000 CD cord-021424-kocwsyi7 29 50 ) ) -RRB- cord-021424-kocwsyi7 29 51 . . . cord-021424-kocwsyi7 30 1 It -PRON- PRP cord-021424-kocwsyi7 30 2 is be VBZ cord-021424-kocwsyi7 30 3 well well RB cord-021424-kocwsyi7 30 4 known know VBN cord-021424-kocwsyi7 30 5 that that IN cord-021424-kocwsyi7 30 6 the the DT cord-021424-kocwsyi7 30 7 cells cell NNS cord-021424-kocwsyi7 30 8 of of IN cord-021424-kocwsyi7 30 9 the the DT cord-021424-kocwsyi7 30 10 host host NN cord-021424-kocwsyi7 30 11 immune immune JJ cord-021424-kocwsyi7 30 12 system system NN cord-021424-kocwsyi7 30 13 are be VBP cord-021424-kocwsyi7 30 14 activated activate VBN cord-021424-kocwsyi7 30 15 upon upon IN cord-021424-kocwsyi7 30 16 detection detection NN cord-021424-kocwsyi7 30 17 of of IN cord-021424-kocwsyi7 30 18 a a DT cord-021424-kocwsyi7 30 19 pathogen pathogen NN cord-021424-kocwsyi7 30 20 by by IN cord-021424-kocwsyi7 30 21 TLRs TLRs NNP cord-021424-kocwsyi7 30 22 as as IN cord-021424-kocwsyi7 30 23 described describe VBN cord-021424-kocwsyi7 30 24 above above RB cord-021424-kocwsyi7 30 25 . . . cord-021424-kocwsyi7 31 1 This this DT cord-021424-kocwsyi7 31 2 activation activation NN cord-021424-kocwsyi7 31 3 process process NN cord-021424-kocwsyi7 31 4 includes include VBZ cord-021424-kocwsyi7 31 5 widespread widespread JJ cord-021424-kocwsyi7 31 6 changes change NNS cord-021424-kocwsyi7 31 7 in in IN cord-021424-kocwsyi7 31 8 the the DT cord-021424-kocwsyi7 31 9 gene gene NN cord-021424-kocwsyi7 31 10 expression expression NN cord-021424-kocwsyi7 31 11 profi profi NNP cord-021424-kocwsyi7 31 12 le le NNP cord-021424-kocwsyi7 31 13 of of IN cord-021424-kocwsyi7 31 14 the the DT cord-021424-kocwsyi7 31 15 cells cell NNS cord-021424-kocwsyi7 31 16 with with IN cord-021424-kocwsyi7 31 17 hundreds hundred NNS cord-021424-kocwsyi7 31 18 of of IN cord-021424-kocwsyi7 31 19 genes gene NNS cord-021424-kocwsyi7 31 20 being be VBG cord-021424-kocwsyi7 31 21 either either CC cord-021424-kocwsyi7 31 22 switched switch VBN cord-021424-kocwsyi7 31 23 on on IN cord-021424-kocwsyi7 31 24 or or CC cord-021424-kocwsyi7 31 25 off off RB cord-021424-kocwsyi7 31 26 in in IN cord-021424-kocwsyi7 31 27 response response NN cord-021424-kocwsyi7 31 28 to to IN cord-021424-kocwsyi7 31 29 signals signal NNS cord-021424-kocwsyi7 31 30 generated generate VBN cord-021424-kocwsyi7 31 31 from from IN cord-021424-kocwsyi7 31 32 the the DT cord-021424-kocwsyi7 31 33 pathogen pathogen NN cord-021424-kocwsyi7 31 34 - - HYPH cord-021424-kocwsyi7 31 35 detecting detect VBG cord-021424-kocwsyi7 31 36 TLRs tlr NNS cord-021424-kocwsyi7 31 37 . . . cord-021424-kocwsyi7 32 1 The the DT cord-021424-kocwsyi7 32 2 response response NN cord-021424-kocwsyi7 32 3 of of IN cord-021424-kocwsyi7 32 4 individual individual JJ cord-021424-kocwsyi7 32 5 genes gene NNS cord-021424-kocwsyi7 32 6 has have VBZ cord-021424-kocwsyi7 32 7 been be VBN cord-021424-kocwsyi7 32 8 studied study VBN cord-021424-kocwsyi7 32 9 in in IN cord-021424-kocwsyi7 32 10 minute minute NN cord-021424-kocwsyi7 32 11 detail detail NN cord-021424-kocwsyi7 32 12 for for IN cord-021424-kocwsyi7 32 13 a a DT cord-021424-kocwsyi7 32 14 handful handful NN cord-021424-kocwsyi7 32 15 of of IN cord-021424-kocwsyi7 32 16 genes gene NNS cord-021424-kocwsyi7 32 17 and and CC cord-021424-kocwsyi7 32 18 while while IN cord-021424-kocwsyi7 32 19 this this DT cord-021424-kocwsyi7 32 20 has have VBZ cord-021424-kocwsyi7 32 21 produced produce VBN cord-021424-kocwsyi7 32 22 an an DT cord-021424-kocwsyi7 32 23 understanding understanding NN cord-021424-kocwsyi7 32 24 of of IN cord-021424-kocwsyi7 32 25 some some DT cord-021424-kocwsyi7 32 26 aspects aspect NNS cord-021424-kocwsyi7 32 27 of of IN cord-021424-kocwsyi7 32 28 host host NN cord-021424-kocwsyi7 32 29 response response NN cord-021424-kocwsyi7 32 30 to to IN cord-021424-kocwsyi7 32 31 infection infection NN cord-021424-kocwsyi7 32 32 it -PRON- PRP cord-021424-kocwsyi7 32 33 by by IN cord-021424-kocwsyi7 32 34 no no DT cord-021424-kocwsyi7 32 35 means means NN cord-021424-kocwsyi7 32 36 gives give VBZ cord-021424-kocwsyi7 32 37 us -PRON- PRP cord-021424-kocwsyi7 32 38 the the DT cord-021424-kocwsyi7 32 39 total total JJ cord-021424-kocwsyi7 32 40 picture picture NN cord-021424-kocwsyi7 32 41 . . . cord-021424-kocwsyi7 33 1 Understanding understand VBG cord-021424-kocwsyi7 33 2 the the DT cord-021424-kocwsyi7 33 3 molecular molecular JJ cord-021424-kocwsyi7 33 4 response response NN cord-021424-kocwsyi7 33 5 of of IN cord-021424-kocwsyi7 33 6 the the DT cord-021424-kocwsyi7 33 7 host host NN cord-021424-kocwsyi7 33 8 to to IN cord-021424-kocwsyi7 33 9 infection infection NN cord-021424-kocwsyi7 33 10 has have VBZ cord-021424-kocwsyi7 33 11 been be VBN cord-021424-kocwsyi7 33 12 greatly greatly RB cord-021424-kocwsyi7 33 13 improved improve VBN cord-021424-kocwsyi7 33 14 by by IN cord-021424-kocwsyi7 33 15 using use VBG cord-021424-kocwsyi7 33 16 microarray microarray NN cord-021424-kocwsyi7 33 17 - - HYPH cord-021424-kocwsyi7 33 18 based base VBN cord-021424-kocwsyi7 33 19 technologies technology NNS cord-021424-kocwsyi7 33 20 and and CC cord-021424-kocwsyi7 33 21 these these DT cord-021424-kocwsyi7 33 22 technologies technology NNS cord-021424-kocwsyi7 33 23 are be VBP cord-021424-kocwsyi7 33 24 opening open VBG cord-021424-kocwsyi7 33 25 up up RP cord-021424-kocwsyi7 33 26 new new JJ cord-021424-kocwsyi7 33 27 diagnostic diagnostic JJ cord-021424-kocwsyi7 33 28 possibilities possibility NNS cord-021424-kocwsyi7 33 29 as as RB cord-021424-kocwsyi7 33 30 well well RB cord-021424-kocwsyi7 33 31 as as IN cord-021424-kocwsyi7 33 32 presenting present VBG cord-021424-kocwsyi7 33 33 new new JJ cord-021424-kocwsyi7 33 34 therapeutic therapeutic JJ cord-021424-kocwsyi7 33 35 options option NNS cord-021424-kocwsyi7 33 36 ( ( -LRB- cord-021424-kocwsyi7 33 37 Aderem Aderem NNP cord-021424-kocwsyi7 33 38 and and CC cord-021424-kocwsyi7 33 39 Smith Smith NNP cord-021424-kocwsyi7 33 40 , , , cord-021424-kocwsyi7 33 41 2004 2004 CD cord-021424-kocwsyi7 33 42 ; ; : cord-021424-kocwsyi7 33 43 Bryant Bryant NNP cord-021424-kocwsyi7 33 44 et et NNP cord-021424-kocwsyi7 33 45 al al NNP cord-021424-kocwsyi7 33 46 . . NNP cord-021424-kocwsyi7 33 47 , , , cord-021424-kocwsyi7 33 48 2004 2004 CD cord-021424-kocwsyi7 33 49 ; ; : cord-021424-kocwsyi7 33 50 Feezor Feezor NNP cord-021424-kocwsyi7 33 51 et et NNP cord-021424-kocwsyi7 33 52 al al NNP cord-021424-kocwsyi7 33 53 . . NNP cord-021424-kocwsyi7 33 54 , , , cord-021424-kocwsyi7 33 55 2005 2005 CD cord-021424-kocwsyi7 33 56 ; ; : cord-021424-kocwsyi7 34 1 Hedeler Hedeler NNP cord-021424-kocwsyi7 34 2 et et NNP cord-021424-kocwsyi7 34 3 al al NNP cord-021424-kocwsyi7 34 4 . . NNP cord-021424-kocwsyi7 34 5 , , , cord-021424-kocwsyi7 34 6 2006 2006 CD cord-021424-kocwsyi7 34 7 ; ; : cord-021424-kocwsyi7 34 8 Korth Korth NNP cord-021424-kocwsyi7 34 9 and and CC cord-021424-kocwsyi7 34 10 Katze Katze NNP cord-021424-kocwsyi7 34 11 , , , cord-021424-kocwsyi7 34 12 2002 2002 CD cord-021424-kocwsyi7 34 13 ; ; : cord-021424-kocwsyi7 34 14 Ng Ng NNP cord-021424-kocwsyi7 34 15 et et NNP cord-021424-kocwsyi7 34 16 al al NNP cord-021424-kocwsyi7 34 17 . . NNP cord-021424-kocwsyi7 34 18 , , , cord-021424-kocwsyi7 34 19 2006 2006 CD cord-021424-kocwsyi7 34 20 ; ; : cord-021424-kocwsyi7 34 21 Ricciardi Ricciardi NNPS cord-021424-kocwsyi7 34 22 - - HYPH cord-021424-kocwsyi7 34 23 Castagnoli Castagnoli NNP cord-021424-kocwsyi7 34 24 , , , cord-021424-kocwsyi7 34 25 2005 2005 CD cord-021424-kocwsyi7 34 26 ; ; : cord-021424-kocwsyi7 34 27 Ricciardi Ricciardi NNPS cord-021424-kocwsyi7 34 28 - - HYPH cord-021424-kocwsyi7 34 29 Castagnoli Castagnoli NNP cord-021424-kocwsyi7 34 30 and and CC cord-021424-kocwsyi7 34 31 Granucci Granucci NNP cord-021424-kocwsyi7 34 32 , , , cord-021424-kocwsyi7 34 33 2002 2002 CD cord-021424-kocwsyi7 34 34 ; ; : cord-021424-kocwsyi7 34 35 Smith Smith NNP cord-021424-kocwsyi7 34 36 and and CC cord-021424-kocwsyi7 34 37 Bolouri Bolouri NNP cord-021424-kocwsyi7 34 38 , , , cord-021424-kocwsyi7 34 39 2005 2005 CD cord-021424-kocwsyi7 34 40 ) ) -RRB- cord-021424-kocwsyi7 34 41 . . . cord-021424-kocwsyi7 35 1 This this DT cord-021424-kocwsyi7 35 2 chapter chapter NN cord-021424-kocwsyi7 35 3 will will MD cord-021424-kocwsyi7 35 4 focus focus VB cord-021424-kocwsyi7 35 5 on on IN cord-021424-kocwsyi7 35 6 two two CD cord-021424-kocwsyi7 35 7 aspects aspect NNS cord-021424-kocwsyi7 35 8 of of IN cord-021424-kocwsyi7 35 9 the the DT cord-021424-kocwsyi7 35 10 host host NN cord-021424-kocwsyi7 35 11 response response NN cord-021424-kocwsyi7 35 12 to to IN cord-021424-kocwsyi7 35 13 pathogens pathogen NNS cord-021424-kocwsyi7 35 14 where where WRB cord-021424-kocwsyi7 35 15 major major JJ cord-021424-kocwsyi7 35 16 advances advance NNS cord-021424-kocwsyi7 35 17 are be VBP cord-021424-kocwsyi7 35 18 being be VBG cord-021424-kocwsyi7 35 19 made make VBN cord-021424-kocwsyi7 35 20 using use VBG cord-021424-kocwsyi7 35 21 genomics genomic NNS cord-021424-kocwsyi7 35 22 approaches approach NNS cord-021424-kocwsyi7 35 23 and and CC cord-021424-kocwsyi7 35 24 will will MD cord-021424-kocwsyi7 35 25 describe describe VB cord-021424-kocwsyi7 35 26 the the DT cord-021424-kocwsyi7 35 27 future future JJ cord-021424-kocwsyi7 35 28 impact impact NN cord-021424-kocwsyi7 35 29 of of IN cord-021424-kocwsyi7 35 30 these these DT cord-021424-kocwsyi7 35 31 approaches approach NNS cord-021424-kocwsyi7 35 32 on on IN cord-021424-kocwsyi7 35 33 the the DT cord-021424-kocwsyi7 35 34 development development NN cord-021424-kocwsyi7 35 35 of of IN cord-021424-kocwsyi7 35 36 diagnostics diagnostic NNS cord-021424-kocwsyi7 35 37 and and CC cord-021424-kocwsyi7 35 38 therapeutics therapeutic NNS cord-021424-kocwsyi7 35 39 for for IN cord-021424-kocwsyi7 35 40 infectious infectious JJ cord-021424-kocwsyi7 35 41 disease disease NN cord-021424-kocwsyi7 35 42 . . . cord-021424-kocwsyi7 36 1 These these DT cord-021424-kocwsyi7 36 2 are be VBP cord-021424-kocwsyi7 36 3 ( ( -LRB- cord-021424-kocwsyi7 36 4 i i NN cord-021424-kocwsyi7 36 5 ) ) -RRB- cord-021424-kocwsyi7 36 6 defi defi NNP cord-021424-kocwsyi7 36 7 ning ning NNP cord-021424-kocwsyi7 36 8 the the DT cord-021424-kocwsyi7 36 9 basis basis NN cord-021424-kocwsyi7 36 10 of of IN cord-021424-kocwsyi7 36 11 genetic genetic JJ cord-021424-kocwsyi7 36 12 susceptibility susceptibility NN cord-021424-kocwsyi7 36 13 to to IN cord-021424-kocwsyi7 36 14 infection infection NN cord-021424-kocwsyi7 36 15 and and CC cord-021424-kocwsyi7 36 16 ( ( -LRB- cord-021424-kocwsyi7 36 17 ii ii NN cord-021424-kocwsyi7 36 18 ) ) -RRB- cord-021424-kocwsyi7 37 1 the the DT cord-021424-kocwsyi7 37 2 defi defi NNP cord-021424-kocwsyi7 37 3 nition nition NN cord-021424-kocwsyi7 37 4 of of IN cord-021424-kocwsyi7 37 5 the the DT cord-021424-kocwsyi7 37 6 system system NN cord-021424-kocwsyi7 37 7 - - HYPH cord-021424-kocwsyi7 37 8 wide wide JJ cord-021424-kocwsyi7 37 9 molecular molecular JJ cord-021424-kocwsyi7 37 10 response response NN cord-021424-kocwsyi7 37 11 to to IN cord-021424-kocwsyi7 37 12 a a DT cord-021424-kocwsyi7 37 13 pathogen pathogen NN cord-021424-kocwsyi7 37 14 . . . cord-021424-kocwsyi7 38 1 It -PRON- PRP cord-021424-kocwsyi7 38 2 is be VBZ cord-021424-kocwsyi7 38 3 now now RB cord-021424-kocwsyi7 38 4 relatively relatively RB cord-021424-kocwsyi7 38 5 easy easy JJ cord-021424-kocwsyi7 38 6 to to TO cord-021424-kocwsyi7 38 7 map map VB cord-021424-kocwsyi7 38 8 genes gene NNS cord-021424-kocwsyi7 38 9 associated associate VBN cord-021424-kocwsyi7 38 10 with with IN cord-021424-kocwsyi7 38 11 genetic genetic JJ cord-021424-kocwsyi7 38 12 diseases disease NNS cord-021424-kocwsyi7 38 13 that that WDT cord-021424-kocwsyi7 38 14 show show VBP cord-021424-kocwsyi7 38 15 a a DT cord-021424-kocwsyi7 38 16 Mendelian mendelian JJ cord-021424-kocwsyi7 38 17 pattern pattern NN cord-021424-kocwsyi7 38 18 of of IN cord-021424-kocwsyi7 38 19 inheritance inheritance NN cord-021424-kocwsyi7 38 20 . . . cord-021424-kocwsyi7 39 1 However however RB cord-021424-kocwsyi7 39 2 , , , cord-021424-kocwsyi7 39 3 these these DT cord-021424-kocwsyi7 39 4 diseases disease NNS cord-021424-kocwsyi7 39 5 account account VBP cord-021424-kocwsyi7 39 6 for for IN cord-021424-kocwsyi7 39 7 only only RB cord-021424-kocwsyi7 39 8 a a DT cord-021424-kocwsyi7 39 9 very very RB cord-021424-kocwsyi7 39 10 small small JJ cord-021424-kocwsyi7 39 11 proportion proportion NN cord-021424-kocwsyi7 39 12 of of IN cord-021424-kocwsyi7 39 13 the the DT cord-021424-kocwsyi7 39 14 human human JJ cord-021424-kocwsyi7 39 15 disease disease NN cord-021424-kocwsyi7 39 16 burden burden NN cord-021424-kocwsyi7 39 17 and and CC cord-021424-kocwsyi7 39 18 many many JJ cord-021424-kocwsyi7 39 19 of of IN cord-021424-kocwsyi7 39 20 the the DT cord-021424-kocwsyi7 39 21 more more RBR cord-021424-kocwsyi7 39 22 common common JJ cord-021424-kocwsyi7 39 23 and and CC cord-021424-kocwsyi7 39 24 fatal fatal JJ cord-021424-kocwsyi7 39 25 diseases disease NNS cord-021424-kocwsyi7 39 26 have have VBP cord-021424-kocwsyi7 39 27 a a DT cord-021424-kocwsyi7 39 28 complex complex JJ cord-021424-kocwsyi7 39 29 etiology etiology NN cord-021424-kocwsyi7 39 30 with with IN cord-021424-kocwsyi7 39 31 many many JJ cord-021424-kocwsyi7 39 32 genetic genetic JJ cord-021424-kocwsyi7 39 33 and and CC cord-021424-kocwsyi7 39 34 environmental environmental JJ cord-021424-kocwsyi7 39 35 contributions contribution NNS cord-021424-kocwsyi7 39 36 . . . cord-021424-kocwsyi7 40 1 While while IN cord-021424-kocwsyi7 40 2 it -PRON- PRP cord-021424-kocwsyi7 40 3 is be VBZ cord-021424-kocwsyi7 40 4 clear clear JJ cord-021424-kocwsyi7 40 5 that that IN cord-021424-kocwsyi7 40 6 most most RBS cord-021424-kocwsyi7 40 7 complex complex JJ cord-021424-kocwsyi7 40 8 disease disease NN cord-021424-kocwsyi7 40 9 has have VBZ cord-021424-kocwsyi7 40 10 a a DT cord-021424-kocwsyi7 40 11 genetic genetic JJ cord-021424-kocwsyi7 40 12 component component NN cord-021424-kocwsyi7 40 13 , , , cord-021424-kocwsyi7 40 14 defi defi NNP cord-021424-kocwsyi7 40 15 ning ning NNP cord-021424-kocwsyi7 40 16 that that DT cord-021424-kocwsyi7 40 17 genetic genetic JJ cord-021424-kocwsyi7 40 18 component component NN cord-021424-kocwsyi7 40 19 has have VBZ cord-021424-kocwsyi7 40 20 been be VBN cord-021424-kocwsyi7 40 21 diffi diffi JJ cord-021424-kocwsyi7 40 22 cult cult NN cord-021424-kocwsyi7 40 23 to to IN cord-021424-kocwsyi7 40 24 date date NN cord-021424-kocwsyi7 40 25 since since IN cord-021424-kocwsyi7 40 26 many many JJ cord-021424-kocwsyi7 40 27 complex complex JJ cord-021424-kocwsyi7 40 28 diseases disease NNS cord-021424-kocwsyi7 40 29 such such JJ cord-021424-kocwsyi7 40 30 as as IN cord-021424-kocwsyi7 40 31 coronary coronary JJ cord-021424-kocwsyi7 40 32 heart heart NN cord-021424-kocwsyi7 40 33 disease disease NN cord-021424-kocwsyi7 40 34 , , , cord-021424-kocwsyi7 40 35 diabetes diabetes NN cord-021424-kocwsyi7 40 36 and and CC cord-021424-kocwsyi7 40 37 others other NNS cord-021424-kocwsyi7 40 38 are be VBP cord-021424-kocwsyi7 40 39 polygenic polygenic JJ cord-021424-kocwsyi7 40 40 with with IN cord-021424-kocwsyi7 40 41 different different JJ cord-021424-kocwsyi7 40 42 genetic genetic JJ cord-021424-kocwsyi7 40 43 loci locus NNS cord-021424-kocwsyi7 40 44 contributing contribute VBG cord-021424-kocwsyi7 40 45 in in IN cord-021424-kocwsyi7 40 46 major major JJ cord-021424-kocwsyi7 40 47 or or CC cord-021424-kocwsyi7 40 48 minor minor JJ cord-021424-kocwsyi7 40 49 ways way NNS cord-021424-kocwsyi7 40 50 to to IN cord-021424-kocwsyi7 40 51 disease disease NN cord-021424-kocwsyi7 40 52 susceptibility susceptibility NN cord-021424-kocwsyi7 40 53 . . . cord-021424-kocwsyi7 41 1 In in IN cord-021424-kocwsyi7 41 2 addition addition NN cord-021424-kocwsyi7 41 3 , , , cord-021424-kocwsyi7 41 4 in in IN cord-021424-kocwsyi7 41 5 different different JJ cord-021424-kocwsyi7 41 6 populations population NNS cord-021424-kocwsyi7 41 7 or or CC cord-021424-kocwsyi7 41 8 under under IN cord-021424-kocwsyi7 41 9 different different JJ cord-021424-kocwsyi7 41 10 environmental environmental JJ cord-021424-kocwsyi7 41 11 conditions condition NNS cord-021424-kocwsyi7 41 12 , , , cord-021424-kocwsyi7 41 13 distinct distinct JJ cord-021424-kocwsyi7 41 14 but but CC cord-021424-kocwsyi7 41 15 overlapping overlapping JJ cord-021424-kocwsyi7 41 16 sets set NNS cord-021424-kocwsyi7 41 17 of of IN cord-021424-kocwsyi7 41 18 genetic genetic JJ cord-021424-kocwsyi7 41 19 loci locus NNS cord-021424-kocwsyi7 41 20 are be VBP cord-021424-kocwsyi7 41 21 likely likely JJ cord-021424-kocwsyi7 41 22 to to TO cord-021424-kocwsyi7 41 23 contribute contribute VB cord-021424-kocwsyi7 41 24 . . . cord-021424-kocwsyi7 42 1 The the DT cord-021424-kocwsyi7 42 2 sequencing sequencing NN cord-021424-kocwsyi7 42 3 of of IN cord-021424-kocwsyi7 42 4 the the DT cord-021424-kocwsyi7 42 5 human human JJ cord-021424-kocwsyi7 42 6 genome genome NN cord-021424-kocwsyi7 42 7 and and CC cord-021424-kocwsyi7 42 8 the the DT cord-021424-kocwsyi7 42 9 genome genome NN cord-021424-kocwsyi7 42 10 - - HYPH cord-021424-kocwsyi7 42 11 wide wide JJ cord-021424-kocwsyi7 42 12 genetic genetic JJ cord-021424-kocwsyi7 42 13 and and CC cord-021424-kocwsyi7 42 14 functional functional JJ cord-021424-kocwsyi7 42 15 mapping mapping NN cord-021424-kocwsyi7 42 16 that that WDT cord-021424-kocwsyi7 42 17 has have VBZ cord-021424-kocwsyi7 42 18 followed follow VBN cord-021424-kocwsyi7 42 19 have have VBP cord-021424-kocwsyi7 42 20 raised raise VBN cord-021424-kocwsyi7 42 21 hopes hope NNS cord-021424-kocwsyi7 42 22 of of IN cord-021424-kocwsyi7 42 23 mapping map VBG cord-021424-kocwsyi7 42 24 the the DT cord-021424-kocwsyi7 42 25 genetic genetic JJ cord-021424-kocwsyi7 42 26 component component NN cord-021424-kocwsyi7 42 27 of of IN cord-021424-kocwsyi7 42 28 complex complex JJ cord-021424-kocwsyi7 42 29 disease disease NN cord-021424-kocwsyi7 42 30 and and CC cord-021424-kocwsyi7 42 31 there there EX cord-021424-kocwsyi7 42 32 are be VBP cord-021424-kocwsyi7 42 33 many many JJ cord-021424-kocwsyi7 42 34 large large JJ cord-021424-kocwsyi7 42 35 efforts effort NNS cord-021424-kocwsyi7 42 36 around around IN cord-021424-kocwsyi7 42 37 the the DT cord-021424-kocwsyi7 42 38 world world NN cord-021424-kocwsyi7 42 39 with with IN cord-021424-kocwsyi7 42 40 this this DT cord-021424-kocwsyi7 42 41 aim aim NN cord-021424-kocwsyi7 42 42 . . . cord-021424-kocwsyi7 43 1 Studies study NNS cord-021424-kocwsyi7 43 2 in in IN cord-021424-kocwsyi7 43 3 both both DT cord-021424-kocwsyi7 43 4 animal animal NN cord-021424-kocwsyi7 43 5 models model NNS cord-021424-kocwsyi7 43 6 and and CC cord-021424-kocwsyi7 43 7 human human JJ cord-021424-kocwsyi7 43 8 populations population NNS cord-021424-kocwsyi7 43 9 have have VBP cord-021424-kocwsyi7 43 10 shown show VBN cord-021424-kocwsyi7 43 11 that that IN cord-021424-kocwsyi7 43 12 infectious infectious JJ cord-021424-kocwsyi7 43 13 disease disease NN cord-021424-kocwsyi7 43 14 and and CC cord-021424-kocwsyi7 43 15 the the DT cord-021424-kocwsyi7 43 16 response response NN cord-021424-kocwsyi7 43 17 of of IN cord-021424-kocwsyi7 43 18 the the DT cord-021424-kocwsyi7 43 19 host host NN cord-021424-kocwsyi7 43 20 to to IN cord-021424-kocwsyi7 43 21 a a DT cord-021424-kocwsyi7 43 22 specifi specifi NN cord-021424-kocwsyi7 43 23 c c NN cord-021424-kocwsyi7 43 24 infection infection NN cord-021424-kocwsyi7 43 25 also also RB cord-021424-kocwsyi7 43 26 has have VBZ cord-021424-kocwsyi7 43 27 a a DT cord-021424-kocwsyi7 43 28 complex complex JJ cord-021424-kocwsyi7 43 29 genetic genetic JJ cord-021424-kocwsyi7 43 30 component component NN cord-021424-kocwsyi7 43 31 ( ( -LRB- cord-021424-kocwsyi7 43 32 Clementi Clementi NNP cord-021424-kocwsyi7 43 33 and and CC cord-021424-kocwsyi7 43 34 Di Di NNP cord-021424-kocwsyi7 43 35 Gianantonio Gianantonio NNP cord-021424-kocwsyi7 43 36 , , , cord-021424-kocwsyi7 43 37 2006 2006 CD cord-021424-kocwsyi7 43 38 ; ; : cord-021424-kocwsyi7 43 39 Lipoldova Lipoldova NNP cord-021424-kocwsyi7 43 40 and and CC cord-021424-kocwsyi7 43 41 Demant Demant NNP cord-021424-kocwsyi7 43 42 , , , cord-021424-kocwsyi7 43 43 2006 2006 CD cord-021424-kocwsyi7 43 44 ; ; : cord-021424-kocwsyi7 43 45 Marquet Marquet NNP cord-021424-kocwsyi7 43 46 et et NNP cord-021424-kocwsyi7 43 47 al al NNP cord-021424-kocwsyi7 43 48 . . NNP cord-021424-kocwsyi7 43 49 , , , cord-021424-kocwsyi7 43 50 1996 1996 CD cord-021424-kocwsyi7 43 51 ; ; . cord-021424-kocwsyi7 44 1 Mira Mira NNP cord-021424-kocwsyi7 44 2 et et NNP cord-021424-kocwsyi7 44 3 al al NNP cord-021424-kocwsyi7 44 4 . . NNP cord-021424-kocwsyi7 44 5 , , , cord-021424-kocwsyi7 44 6 2004 2004 CD cord-021424-kocwsyi7 44 7 ) ) -RRB- cord-021424-kocwsyi7 44 8 . . . cord-021424-kocwsyi7 45 1 Thus thus RB cord-021424-kocwsyi7 45 2 , , , cord-021424-kocwsyi7 45 3 inbred inbred JJ cord-021424-kocwsyi7 45 4 mouse mouse NN cord-021424-kocwsyi7 45 5 models model NNS cord-021424-kocwsyi7 45 6 have have VBP cord-021424-kocwsyi7 45 7 been be VBN cord-021424-kocwsyi7 45 8 developed develop VBN cord-021424-kocwsyi7 45 9 that that WDT cord-021424-kocwsyi7 45 10 clearly clearly RB cord-021424-kocwsyi7 45 11 show show VBP cord-021424-kocwsyi7 45 12 a a DT cord-021424-kocwsyi7 45 13 genetic genetic JJ cord-021424-kocwsyi7 45 14 component component NN cord-021424-kocwsyi7 45 15 to to IN cord-021424-kocwsyi7 45 16 susceptibility susceptibility NN cord-021424-kocwsyi7 45 17 for for IN cord-021424-kocwsyi7 45 18 specifi specifi NNP cord-021424-kocwsyi7 45 19 c c NN cord-021424-kocwsyi7 45 20 pathogens pathogen NNS cord-021424-kocwsyi7 45 21 and and CC cord-021424-kocwsyi7 45 22 in in IN cord-021424-kocwsyi7 45 23 some some DT cord-021424-kocwsyi7 45 24 cases case NNS cord-021424-kocwsyi7 45 25 at at IN cord-021424-kocwsyi7 45 26 least least JJS cord-021424-kocwsyi7 45 27 part part NN cord-021424-kocwsyi7 45 28 of of IN cord-021424-kocwsyi7 45 29 the the DT cord-021424-kocwsyi7 45 30 underlying underlying JJ cord-021424-kocwsyi7 45 31 genetic genetic JJ cord-021424-kocwsyi7 45 32 reason reason NN cord-021424-kocwsyi7 45 33 has have VBZ cord-021424-kocwsyi7 45 34 been be VBN cord-021424-kocwsyi7 45 35 defi defi NNP cord-021424-kocwsyi7 45 36 ned ned NNP cord-021424-kocwsyi7 45 37 ( ( -LRB- cord-021424-kocwsyi7 45 38 Beck Beck NNP cord-021424-kocwsyi7 45 39 et et NNP cord-021424-kocwsyi7 45 40 al al NNP cord-021424-kocwsyi7 45 41 . . NNP cord-021424-kocwsyi7 45 42 , , , cord-021424-kocwsyi7 45 43 2000 2000 CD cord-021424-kocwsyi7 45 44 ; ; : cord-021424-kocwsyi7 46 1 Mak Mak NNP cord-021424-kocwsyi7 46 2 et et NNP cord-021424-kocwsyi7 46 3 al al NNP cord-021424-kocwsyi7 46 4 . . NNP cord-021424-kocwsyi7 46 5 , , , cord-021424-kocwsyi7 46 6 2001 2001 CD cord-021424-kocwsyi7 46 7 ; ; : cord-021424-kocwsyi7 46 8 Rogner Rogner NNP cord-021424-kocwsyi7 46 9 and and CC cord-021424-kocwsyi7 46 10 Avner Avner NNP cord-021424-kocwsyi7 46 11 , , , cord-021424-kocwsyi7 46 12 2003 2003 CD cord-021424-kocwsyi7 46 13 ) ) -RRB- cord-021424-kocwsyi7 46 14 . . . cord-021424-kocwsyi7 47 1 Mapping map VBG cord-021424-kocwsyi7 47 2 the the DT cord-021424-kocwsyi7 47 3 genetic genetic JJ cord-021424-kocwsyi7 47 4 components component NNS cord-021424-kocwsyi7 47 5 of of IN cord-021424-kocwsyi7 47 6 susceptibility susceptibility NN cord-021424-kocwsyi7 47 7 to to IN cord-021424-kocwsyi7 47 8 infection infection NN cord-021424-kocwsyi7 47 9 in in IN cord-021424-kocwsyi7 47 10 human human JJ cord-021424-kocwsyi7 47 11 populations population NNS cord-021424-kocwsyi7 47 12 has have VBZ cord-021424-kocwsyi7 47 13 been be VBN cord-021424-kocwsyi7 47 14 much much RB cord-021424-kocwsyi7 47 15 more more RBR cord-021424-kocwsyi7 47 16 difficult difficult JJ cord-021424-kocwsyi7 47 17 due due IN cord-021424-kocwsyi7 47 18 to to IN cord-021424-kocwsyi7 47 19 the the DT cord-021424-kocwsyi7 47 20 large large JJ cord-021424-kocwsyi7 47 21 natural natural JJ cord-021424-kocwsyi7 47 22 variation variation NN cord-021424-kocwsyi7 47 23 in in IN cord-021424-kocwsyi7 47 24 humans human NNS cord-021424-kocwsyi7 47 25 , , , cord-021424-kocwsyi7 47 26 the the DT cord-021424-kocwsyi7 47 27 polygenic polygenic JJ cord-021424-kocwsyi7 47 28 nature nature NN cord-021424-kocwsyi7 47 29 of of IN cord-021424-kocwsyi7 47 30 this this DT cord-021424-kocwsyi7 47 31 trait trait NN cord-021424-kocwsyi7 47 32 and and CC cord-021424-kocwsyi7 47 33 the the DT cord-021424-kocwsyi7 47 34 low low JJ cord-021424-kocwsyi7 47 35 penetrance penetrance NN cord-021424-kocwsyi7 47 36 of of IN cord-021424-kocwsyi7 47 37 many many JJ cord-021424-kocwsyi7 47 38 of of IN cord-021424-kocwsyi7 47 39 the the DT cord-021424-kocwsyi7 47 40 susceptibility susceptibility NN cord-021424-kocwsyi7 47 41 alleles allele NNS cord-021424-kocwsyi7 47 42 . . . cord-021424-kocwsyi7 48 1 For for IN cord-021424-kocwsyi7 48 2 infectious infectious JJ cord-021424-kocwsyi7 48 3 disease disease NN cord-021424-kocwsyi7 48 4 , , , cord-021424-kocwsyi7 48 5 this this DT cord-021424-kocwsyi7 48 6 is be VBZ cord-021424-kocwsyi7 48 7 complicated complicate VBN cord-021424-kocwsyi7 48 8 even even RB cord-021424-kocwsyi7 48 9 more more RBR cord-021424-kocwsyi7 48 10 by by IN cord-021424-kocwsyi7 48 11 the the DT cord-021424-kocwsyi7 48 12 complex complex JJ cord-021424-kocwsyi7 48 13 nature nature NN cord-021424-kocwsyi7 48 14 of of IN cord-021424-kocwsyi7 48 15 the the DT cord-021424-kocwsyi7 48 16 environmental environmental JJ cord-021424-kocwsyi7 48 17 infl infl NN cord-021424-kocwsyi7 48 18 uences uence NNS cord-021424-kocwsyi7 48 19 particularly particularly RB cord-021424-kocwsyi7 48 20 the the DT cord-021424-kocwsyi7 48 21 fact fact NN cord-021424-kocwsyi7 48 22 that that IN cord-021424-kocwsyi7 48 23 these these DT cord-021424-kocwsyi7 48 24 diseases disease NNS cord-021424-kocwsyi7 48 25 , , , cord-021424-kocwsyi7 48 26 unlike unlike IN cord-021424-kocwsyi7 48 27 other other JJ cord-021424-kocwsyi7 48 28 complex complex JJ cord-021424-kocwsyi7 48 29 diseases disease NNS cord-021424-kocwsyi7 48 30 , , , cord-021424-kocwsyi7 48 31 are be VBP cord-021424-kocwsyi7 48 32 transmissible transmissible JJ cord-021424-kocwsyi7 48 33 in in IN cord-021424-kocwsyi7 48 34 populations population NNS cord-021424-kocwsyi7 48 35 . . . cord-021424-kocwsyi7 49 1 However however RB cord-021424-kocwsyi7 49 2 , , , cord-021424-kocwsyi7 49 3 a a DT cord-021424-kocwsyi7 49 4 combination combination NN cord-021424-kocwsyi7 49 5 of of IN cord-021424-kocwsyi7 49 6 animal animal NN cord-021424-kocwsyi7 49 7 and and CC cord-021424-kocwsyi7 49 8 human human JJ cord-021424-kocwsyi7 49 9 population population NN cord-021424-kocwsyi7 49 10 studies study NNS cord-021424-kocwsyi7 49 11 , , , cord-021424-kocwsyi7 49 12 combined combine VBN cord-021424-kocwsyi7 49 13 with with IN cord-021424-kocwsyi7 49 14 the the DT cord-021424-kocwsyi7 49 15 latest late JJS cord-021424-kocwsyi7 49 16 genomic genomic JJ cord-021424-kocwsyi7 49 17 technologies technology NNS cord-021424-kocwsyi7 49 18 , , , cord-021424-kocwsyi7 49 19 is be VBZ cord-021424-kocwsyi7 49 20 beginning begin VBG cord-021424-kocwsyi7 49 21 to to TO cord-021424-kocwsyi7 49 22 unravel unravel VB cord-021424-kocwsyi7 49 23 the the DT cord-021424-kocwsyi7 49 24 issues issue NNS cord-021424-kocwsyi7 49 25 of of IN cord-021424-kocwsyi7 49 26 genetic genetic JJ cord-021424-kocwsyi7 49 27 susceptibility susceptibility NN cord-021424-kocwsyi7 49 28 to to IN cord-021424-kocwsyi7 49 29 infection infection NN cord-021424-kocwsyi7 49 30 . . . cord-021424-kocwsyi7 50 1 The the DT cord-021424-kocwsyi7 50 2 use use NN cord-021424-kocwsyi7 50 3 of of IN cord-021424-kocwsyi7 50 4 inbred inbred JJ cord-021424-kocwsyi7 50 5 and and CC cord-021424-kocwsyi7 50 6 congenic congenic JJ cord-021424-kocwsyi7 50 7 strains strain NNS cord-021424-kocwsyi7 50 8 of of IN cord-021424-kocwsyi7 50 9 mice mouse NNS cord-021424-kocwsyi7 50 10 are be VBP cord-021424-kocwsyi7 50 11 well well RB cord-021424-kocwsyi7 50 12 established establish VBN cord-021424-kocwsyi7 50 13 systems system NNS cord-021424-kocwsyi7 50 14 for for IN cord-021424-kocwsyi7 50 15 identifying identify VBG cord-021424-kocwsyi7 50 16 susceptibility susceptibility NN cord-021424-kocwsyi7 50 17 loci locus NNS cord-021424-kocwsyi7 50 18 ( ( -LRB- cord-021424-kocwsyi7 50 19 Beck Beck NNP cord-021424-kocwsyi7 50 20 et et NNP cord-021424-kocwsyi7 50 21 al al NNP cord-021424-kocwsyi7 50 22 . . NNP cord-021424-kocwsyi7 50 23 , , , cord-021424-kocwsyi7 50 24 2000 2000 CD cord-021424-kocwsyi7 50 25 ; ; : cord-021424-kocwsyi7 50 26 Rogner Rogner NNP cord-021424-kocwsyi7 50 27 and and CC cord-021424-kocwsyi7 50 28 Avner Avner NNP cord-021424-kocwsyi7 50 29 , , , cord-021424-kocwsyi7 50 30 2003 2003 CD cord-021424-kocwsyi7 50 31 ) ) -RRB- cord-021424-kocwsyi7 50 32 . . . cord-021424-kocwsyi7 51 1 In in IN cord-021424-kocwsyi7 51 2 recent recent JJ cord-021424-kocwsyi7 51 3 years year NNS cord-021424-kocwsyi7 51 4 genetic genetic JJ cord-021424-kocwsyi7 51 5 manipulation manipulation NN cord-021424-kocwsyi7 51 6 of of IN cord-021424-kocwsyi7 51 7 specifi specifi NN cord-021424-kocwsyi7 51 8 c c NN cord-021424-kocwsyi7 51 9 loci locus NNS cord-021424-kocwsyi7 51 10 by by IN cord-021424-kocwsyi7 51 11 deletion deletion NN cord-021424-kocwsyi7 51 12 or or CC cord-021424-kocwsyi7 51 13 mutation mutation NN cord-021424-kocwsyi7 51 14 has have VBZ cord-021424-kocwsyi7 51 15 provided provide VBN cord-021424-kocwsyi7 51 16 many many JJ cord-021424-kocwsyi7 51 17 mouse mouse NN cord-021424-kocwsyi7 51 18 models model NNS cord-021424-kocwsyi7 51 19 for for IN cord-021424-kocwsyi7 51 20 screening screening NN cord-021424-kocwsyi7 52 1 ( ( -LRB- cord-021424-kocwsyi7 52 2 Mak Mak NNP cord-021424-kocwsyi7 52 3 et et NNP cord-021424-kocwsyi7 52 4 al al NNP cord-021424-kocwsyi7 52 5 . . NNP cord-021424-kocwsyi7 52 6 , , , cord-021424-kocwsyi7 52 7 2001 2001 CD cord-021424-kocwsyi7 52 8 ) ) -RRB- cord-021424-kocwsyi7 52 9 . . . cord-021424-kocwsyi7 53 1 The the DT cord-021424-kocwsyi7 53 2 use use NN cord-021424-kocwsyi7 53 3 of of IN cord-021424-kocwsyi7 53 4 ethylnitrosourea ethylnitrosourea NN cord-021424-kocwsyi7 53 5 ( ( -LRB- cord-021424-kocwsyi7 53 6 ENU ENU NNP cord-021424-kocwsyi7 53 7 ) ) -RRB- cord-021424-kocwsyi7 53 8 mutagenesis mutagenesis NN cord-021424-kocwsyi7 53 9 to to TO cord-021424-kocwsyi7 53 10 randomly randomly RB cord-021424-kocwsyi7 53 11 create create VB cord-021424-kocwsyi7 53 12 point point NN cord-021424-kocwsyi7 53 13 mutations mutation NNS cord-021424-kocwsyi7 53 14 in in IN cord-021424-kocwsyi7 53 15 the the DT cord-021424-kocwsyi7 53 16 mouse mouse NN cord-021424-kocwsyi7 53 17 genome genome NN cord-021424-kocwsyi7 53 18 has have VBZ cord-021424-kocwsyi7 53 19 opened open VBN cord-021424-kocwsyi7 53 20 up up RP cord-021424-kocwsyi7 53 21 a a DT cord-021424-kocwsyi7 53 22 new new JJ cord-021424-kocwsyi7 53 23 forward forward JJ cord-021424-kocwsyi7 53 24 genetics genetics NN cord-021424-kocwsyi7 53 25 approach approach NN cord-021424-kocwsyi7 53 26 to to IN cord-021424-kocwsyi7 53 27 identifying identify VBG cord-021424-kocwsyi7 53 28 susceptibility susceptibility NN cord-021424-kocwsyi7 53 29 loci locus NNS cord-021424-kocwsyi7 53 30 ( ( -LRB- cord-021424-kocwsyi7 53 31 Papathanasiou Papathanasiou NNP cord-021424-kocwsyi7 53 32 and and CC cord-021424-kocwsyi7 53 33 Goodnow Goodnow NNP cord-021424-kocwsyi7 53 34 , , , cord-021424-kocwsyi7 53 35 2005 2005 CD cord-021424-kocwsyi7 53 36 ) ) -RRB- cord-021424-kocwsyi7 53 37 . . . cord-021424-kocwsyi7 54 1 This this DT cord-021424-kocwsyi7 54 2 chemical chemical NN cord-021424-kocwsyi7 54 3 mutagen mutagen NN cord-021424-kocwsyi7 54 4 , , , cord-021424-kocwsyi7 54 5 when when WRB cord-021424-kocwsyi7 54 6 used use VBN cord-021424-kocwsyi7 54 7 at at IN cord-021424-kocwsyi7 54 8 appropriate appropriate JJ cord-021424-kocwsyi7 54 9 doses dose NNS cord-021424-kocwsyi7 54 10 and and CC cord-021424-kocwsyi7 54 11 at at IN cord-021424-kocwsyi7 54 12 the the DT cord-021424-kocwsyi7 54 13 correct correct JJ cord-021424-kocwsyi7 54 14 stage stage NN cord-021424-kocwsyi7 54 15 of of IN cord-021424-kocwsyi7 54 16 development development NN cord-021424-kocwsyi7 54 17 , , , cord-021424-kocwsyi7 54 18 can can MD cord-021424-kocwsyi7 54 19 introduce introduce VB cord-021424-kocwsyi7 54 20 single single JJ cord-021424-kocwsyi7 54 21 point point NN cord-021424-kocwsyi7 54 22 mutations mutation NNS cord-021424-kocwsyi7 54 23 into into IN cord-021424-kocwsyi7 54 24 the the DT cord-021424-kocwsyi7 54 25 mouse mouse NN cord-021424-kocwsyi7 54 26 genome genome NN cord-021424-kocwsyi7 54 27 . . . cord-021424-kocwsyi7 55 1 By by IN cord-021424-kocwsyi7 55 2 screening screen VBG cord-021424-kocwsyi7 55 3 libraries library NNS cord-021424-kocwsyi7 55 4 of of IN cord-021424-kocwsyi7 55 5 mutant mutant JJ cord-021424-kocwsyi7 55 6 mice mouse NNS cord-021424-kocwsyi7 55 7 for for IN cord-021424-kocwsyi7 55 8 susceptibility susceptibility NN cord-021424-kocwsyi7 55 9 to to IN cord-021424-kocwsyi7 55 10 specifi specifi NNP cord-021424-kocwsyi7 55 11 c c NN cord-021424-kocwsyi7 55 12 pathogens pathogen NNS cord-021424-kocwsyi7 55 13 , , , cord-021424-kocwsyi7 55 14 it -PRON- PRP cord-021424-kocwsyi7 55 15 should should MD cord-021424-kocwsyi7 55 16 be be VB cord-021424-kocwsyi7 55 17 possible possible JJ cord-021424-kocwsyi7 55 18 to to TO cord-021424-kocwsyi7 55 19 identify identify VB cord-021424-kocwsyi7 55 20 genetic genetic JJ cord-021424-kocwsyi7 55 21 loci locus NNS cord-021424-kocwsyi7 55 22 that that WDT cord-021424-kocwsyi7 55 23 dictate dictate VBP cord-021424-kocwsyi7 55 24 susceptibility susceptibility NN cord-021424-kocwsyi7 55 25 or or CC cord-021424-kocwsyi7 55 26 resistance resistance NN cord-021424-kocwsyi7 55 27 to to IN cord-021424-kocwsyi7 55 28 a a DT cord-021424-kocwsyi7 55 29 range range NN cord-021424-kocwsyi7 55 30 of of IN cord-021424-kocwsyi7 55 31 pathogens pathogen NNS cord-021424-kocwsyi7 55 32 on on IN cord-021424-kocwsyi7 55 33 a a DT cord-021424-kocwsyi7 55 34 large large JJ cord-021424-kocwsyi7 55 35 scale scale NN cord-021424-kocwsyi7 55 36 . . . cord-021424-kocwsyi7 56 1 It -PRON- PRP cord-021424-kocwsyi7 56 2 is be VBZ cord-021424-kocwsyi7 56 3 relatively relatively RB cord-021424-kocwsyi7 56 4 straightforward straightforward JJ cord-021424-kocwsyi7 56 5 to to TO cord-021424-kocwsyi7 56 6 identify identify VB cord-021424-kocwsyi7 56 7 a a DT cord-021424-kocwsyi7 56 8 chromosomal chromosomal JJ cord-021424-kocwsyi7 56 9 region region NN cord-021424-kocwsyi7 56 10 involved involve VBN cord-021424-kocwsyi7 56 11 in in IN cord-021424-kocwsyi7 56 12 susceptibility susceptibility NN cord-021424-kocwsyi7 56 13 in in IN cord-021424-kocwsyi7 56 14 these these DT cord-021424-kocwsyi7 56 15 mouse mouse NN cord-021424-kocwsyi7 56 16 strains strain NNS cord-021424-kocwsyi7 56 17 by by IN cord-021424-kocwsyi7 56 18 genotyping genotype VBG cord-021424-kocwsyi7 56 19 with with IN cord-021424-kocwsyi7 56 20 microsatellite microsatellite JJ cord-021424-kocwsyi7 56 21 markers marker NNS cord-021424-kocwsyi7 56 22 , , , cord-021424-kocwsyi7 56 23 but but CC cord-021424-kocwsyi7 56 24 identifying identify VBG cord-021424-kocwsyi7 56 25 the the DT cord-021424-kocwsyi7 56 26 specifi specifi NNP cord-021424-kocwsyi7 56 27 c c NN cord-021424-kocwsyi7 56 28 gene gene NN cord-021424-kocwsyi7 56 29 that that WDT cord-021424-kocwsyi7 56 30 is be VBZ cord-021424-kocwsyi7 56 31 mutated mutate VBN cord-021424-kocwsyi7 56 32 is be VBZ cord-021424-kocwsyi7 56 33 still still RB cord-021424-kocwsyi7 56 34 very very RB cord-021424-kocwsyi7 56 35 time time NN cord-021424-kocwsyi7 56 36 - - HYPH cord-021424-kocwsyi7 56 37 consuming consume VBG cord-021424-kocwsyi7 56 38 . . . cord-021424-kocwsyi7 57 1 The the DT cord-021424-kocwsyi7 57 2 speed speed NN cord-021424-kocwsyi7 57 3 with with IN cord-021424-kocwsyi7 57 4 which which WDT cord-021424-kocwsyi7 57 5 this this DT cord-021424-kocwsyi7 57 6 can can MD cord-021424-kocwsyi7 57 7 be be VB cord-021424-kocwsyi7 57 8 achieved achieve VBN cord-021424-kocwsyi7 57 9 depends depend VBZ cord-021424-kocwsyi7 57 10 on on IN cord-021424-kocwsyi7 57 11 the the DT cord-021424-kocwsyi7 57 12 presence presence NN cord-021424-kocwsyi7 57 13 of of IN cord-021424-kocwsyi7 57 14 candidate candidate NN cord-021424-kocwsyi7 57 15 genes gene NNS cord-021424-kocwsyi7 57 16 within within IN cord-021424-kocwsyi7 57 17 the the DT cord-021424-kocwsyi7 57 18 chromosomal chromosomal JJ cord-021424-kocwsyi7 57 19 interval interval NN cord-021424-kocwsyi7 57 20 or or CC cord-021424-kocwsyi7 57 21 the the DT cord-021424-kocwsyi7 57 22 ability ability NN cord-021424-kocwsyi7 57 23 to to TO cord-021424-kocwsyi7 57 24 resequence resequence VB cord-021424-kocwsyi7 57 25 large large JJ cord-021424-kocwsyi7 57 26 amounts amount NNS cord-021424-kocwsyi7 57 27 of of IN cord-021424-kocwsyi7 57 28 DNA dna NN cord-021424-kocwsyi7 57 29 . . . cord-021424-kocwsyi7 58 1 The the DT cord-021424-kocwsyi7 58 2 latter latter JJ cord-021424-kocwsyi7 58 3 is be VBZ cord-021424-kocwsyi7 58 4 becoming become VBG cord-021424-kocwsyi7 58 5 achievable achievable JJ cord-021424-kocwsyi7 58 6 with with IN cord-021424-kocwsyi7 58 7 the the DT cord-021424-kocwsyi7 58 8 advent advent NN cord-021424-kocwsyi7 58 9 of of IN cord-021424-kocwsyi7 58 10 new new JJ cord-021424-kocwsyi7 58 11 rapid rapid JJ cord-021424-kocwsyi7 58 12 sequencing sequencing NN cord-021424-kocwsyi7 58 13 technologies technology NNS cord-021424-kocwsyi7 58 14 and and CC cord-021424-kocwsyi7 58 15 is be VBZ cord-021424-kocwsyi7 58 16 set set VBN cord-021424-kocwsyi7 58 17 to to TO cord-021424-kocwsyi7 58 18 revolutionize revolutionize VB cord-021424-kocwsyi7 58 19 forward forward RB cord-021424-kocwsyi7 58 20 genetic genetic JJ cord-021424-kocwsyi7 58 21 approaches approach NNS cord-021424-kocwsyi7 58 22 to to IN cord-021424-kocwsyi7 58 23 disease disease NN cord-021424-kocwsyi7 58 24 understanding understanding NN cord-021424-kocwsyi7 58 25 ( ( -LRB- cord-021424-kocwsyi7 58 26 Bennett Bennett NNP cord-021424-kocwsyi7 58 27 et et NNP cord-021424-kocwsyi7 58 28 al al NNP cord-021424-kocwsyi7 58 29 . . NNP cord-021424-kocwsyi7 58 30 , , , cord-021424-kocwsyi7 58 31 2005 2005 CD cord-021424-kocwsyi7 58 32 ; ; : cord-021424-kocwsyi7 58 33 Serre Serre NNP cord-021424-kocwsyi7 58 34 and and CC cord-021424-kocwsyi7 58 35 Hudson Hudson NNP cord-021424-kocwsyi7 58 36 , , , cord-021424-kocwsyi7 58 37 2006 2006 CD cord-021424-kocwsyi7 58 38 ) ) -RRB- cord-021424-kocwsyi7 58 39 . . . cord-021424-kocwsyi7 59 1 The the DT cord-021424-kocwsyi7 59 2 recent recent JJ cord-021424-kocwsyi7 59 3 explosion explosion NN cord-021424-kocwsyi7 59 4 in in IN cord-021424-kocwsyi7 59 5 genetic genetic JJ cord-021424-kocwsyi7 59 6 information information NN cord-021424-kocwsyi7 59 7 for for IN cord-021424-kocwsyi7 59 8 the the DT cord-021424-kocwsyi7 59 9 human human JJ cord-021424-kocwsyi7 59 10 genome genome NN cord-021424-kocwsyi7 59 11 including include VBG cord-021424-kocwsyi7 59 12 the the DT cord-021424-kocwsyi7 59 13 complete complete JJ cord-021424-kocwsyi7 59 14 genome genome NN cord-021424-kocwsyi7 59 15 sequence sequence NN cord-021424-kocwsyi7 59 16 and and CC cord-021424-kocwsyi7 59 17 detailed detailed JJ cord-021424-kocwsyi7 59 18 genetic genetic JJ cord-021424-kocwsyi7 59 19 and and CC cord-021424-kocwsyi7 59 20 physical physical JJ cord-021424-kocwsyi7 59 21 maps map NNS cord-021424-kocwsyi7 59 22 has have VBZ cord-021424-kocwsyi7 59 23 increased increase VBN cord-021424-kocwsyi7 59 24 our -PRON- PRP$ cord-021424-kocwsyi7 59 25 ability ability NN cord-021424-kocwsyi7 59 26 to to TO cord-021424-kocwsyi7 59 27 fi fi VB cord-021424-kocwsyi7 59 28 nd nd NNP cord-021424-kocwsyi7 59 29 variation variation NN cord-021424-kocwsyi7 59 30 in in IN cord-021424-kocwsyi7 59 31 the the DT cord-021424-kocwsyi7 59 32 human human JJ cord-021424-kocwsyi7 59 33 genome genome NN cord-021424-kocwsyi7 59 34 and and CC cord-021424-kocwsyi7 59 35 correlate correlate VB cord-021424-kocwsyi7 59 36 it -PRON- PRP cord-021424-kocwsyi7 59 37 with with IN cord-021424-kocwsyi7 59 38 disease disease NN cord-021424-kocwsyi7 59 39 . . . cord-021424-kocwsyi7 60 1 Family family NN cord-021424-kocwsyi7 60 2 studies study NNS cord-021424-kocwsyi7 60 3 , , , cord-021424-kocwsyi7 60 4 especially especially RB cord-021424-kocwsyi7 60 5 twin twin JJ cord-021424-kocwsyi7 60 6 studies study NNS cord-021424-kocwsyi7 60 7 , , , cord-021424-kocwsyi7 60 8 and and CC cord-021424-kocwsyi7 60 9 population population NN cord-021424-kocwsyi7 60 10 studies study NNS cord-021424-kocwsyi7 60 11 have have VBP cord-021424-kocwsyi7 60 12 clearly clearly RB cord-021424-kocwsyi7 60 13 shown show VBN cord-021424-kocwsyi7 60 14 a a DT cord-021424-kocwsyi7 60 15 genetic genetic JJ cord-021424-kocwsyi7 60 16 component component NN cord-021424-kocwsyi7 60 17 to to IN cord-021424-kocwsyi7 60 18 susceptibility susceptibility NN cord-021424-kocwsyi7 60 19 to to IN cord-021424-kocwsyi7 60 20 infectious infectious JJ cord-021424-kocwsyi7 60 21 disease disease NN cord-021424-kocwsyi7 60 22 ( ( -LRB- cord-021424-kocwsyi7 60 23 Frodsham Frodsham NNP cord-021424-kocwsyi7 60 24 and and CC cord-021424-kocwsyi7 60 25 Hill Hill NNP cord-021424-kocwsyi7 60 26 , , , cord-021424-kocwsyi7 60 27 2004 2004 CD cord-021424-kocwsyi7 60 28 ; ; : cord-021424-kocwsyi7 60 29 Lipoldova Lipoldova NNP cord-021424-kocwsyi7 60 30 and and CC cord-021424-kocwsyi7 60 31 Demant Demant NNP cord-021424-kocwsyi7 60 32 , , , cord-021424-kocwsyi7 60 33 2006 2006 CD cord-021424-kocwsyi7 60 34 ; ; : cord-021424-kocwsyi7 60 35 Strunk Strunk NNP cord-021424-kocwsyi7 60 36 and and CC cord-021424-kocwsyi7 60 37 Burgner Burgner NNP cord-021424-kocwsyi7 60 38 , , , cord-021424-kocwsyi7 60 39 2006 2006 CD cord-021424-kocwsyi7 60 40 ) ) -RRB- cord-021424-kocwsyi7 60 41 . . . cord-021424-kocwsyi7 61 1 Susceptibility susceptibility NN cord-021424-kocwsyi7 61 2 generally generally RB cord-021424-kocwsyi7 61 3 follows follow VBZ cord-021424-kocwsyi7 61 4 a a DT cord-021424-kocwsyi7 61 5 complex complex JJ cord-021424-kocwsyi7 61 6 pattern pattern NN cord-021424-kocwsyi7 61 7 of of IN cord-021424-kocwsyi7 61 8 inheritance inheritance NN cord-021424-kocwsyi7 61 9 and and CC cord-021424-kocwsyi7 61 10 there there EX cord-021424-kocwsyi7 61 11 are be VBP cord-021424-kocwsyi7 61 12 two two CD cord-021424-kocwsyi7 61 13 main main JJ cord-021424-kocwsyi7 61 14 methods method NNS cord-021424-kocwsyi7 61 15 of of IN cord-021424-kocwsyi7 61 16 mapping mapping NN cord-021424-kocwsyi7 61 17 and and CC cord-021424-kocwsyi7 61 18 identifying identify VBG cord-021424-kocwsyi7 61 19 genetic genetic JJ cord-021424-kocwsyi7 61 20 loci locus NNS cord-021424-kocwsyi7 61 21 involved involve VBN cord-021424-kocwsyi7 61 22 in in IN cord-021424-kocwsyi7 61 23 such such JJ cord-021424-kocwsyi7 61 24 complex complex JJ cord-021424-kocwsyi7 61 25 heredity heredity NN cord-021424-kocwsyi7 61 26 . . . cord-021424-kocwsyi7 62 1 These these DT cord-021424-kocwsyi7 62 2 are be VBP cord-021424-kocwsyi7 62 3 either either CC cord-021424-kocwsyi7 62 4 association association NN cord-021424-kocwsyi7 62 5 studies study NNS cord-021424-kocwsyi7 62 6 or or CC cord-021424-kocwsyi7 62 7 linkage linkage NN cord-021424-kocwsyi7 62 8 studies study NNS cord-021424-kocwsyi7 62 9 . . . cord-021424-kocwsyi7 63 1 Association Association NNP cord-021424-kocwsyi7 63 2 studies study NNS cord-021424-kocwsyi7 63 3 involve involve VBP cord-021424-kocwsyi7 63 4 screening screen VBG cord-021424-kocwsyi7 63 5 populations population NNS cord-021424-kocwsyi7 63 6 for for IN cord-021424-kocwsyi7 63 7 specifi specifi NNP cord-021424-kocwsyi7 63 8 c c NN cord-021424-kocwsyi7 63 9 mutations mutation NNS cord-021424-kocwsyi7 63 10 in in IN cord-021424-kocwsyi7 63 11 a a DT cord-021424-kocwsyi7 63 12 candidate candidate NN cord-021424-kocwsyi7 63 13 gene(s gene(s RB cord-021424-kocwsyi7 63 14 ) ) -RRB- cord-021424-kocwsyi7 63 15 in in IN cord-021424-kocwsyi7 63 16 case case NN cord-021424-kocwsyi7 63 17 - - HYPH cord-021424-kocwsyi7 63 18 control control NN cord-021424-kocwsyi7 63 19 studies study NNS cord-021424-kocwsyi7 63 20 or or CC cord-021424-kocwsyi7 63 21 in in IN cord-021424-kocwsyi7 63 22 family family NN cord-021424-kocwsyi7 63 23 studies study NNS cord-021424-kocwsyi7 63 24 . . . cord-021424-kocwsyi7 64 1 This this DT cord-021424-kocwsyi7 64 2 type type NN cord-021424-kocwsyi7 64 3 of of IN cord-021424-kocwsyi7 64 4 approach approach NN cord-021424-kocwsyi7 64 5 identifi identifi NNP cord-021424-kocwsyi7 64 6 ed ed NNP cord-021424-kocwsyi7 64 7 the the DT cord-021424-kocwsyi7 64 8 link link NN cord-021424-kocwsyi7 64 9 between between IN cord-021424-kocwsyi7 64 10 Human Human NNP cord-021424-kocwsyi7 64 11 Immunodefi Immunodefi NNP cord-021424-kocwsyi7 64 12 ciency ciency NN cord-021424-kocwsyi7 64 13 Virus virus NN cord-021424-kocwsyi7 64 14 ( ( -LRB- cord-021424-kocwsyi7 64 15 HIV HIV NNP cord-021424-kocwsyi7 64 16 ) ) -RRB- cord-021424-kocwsyi7 64 17 resistance resistance NN cord-021424-kocwsyi7 64 18 and and CC cord-021424-kocwsyi7 64 19 the the DT cord-021424-kocwsyi7 64 20 chemokine chemokine NN cord-021424-kocwsyi7 64 21 receptor receptor NN cord-021424-kocwsyi7 64 22 , , , cord-021424-kocwsyi7 65 1 CCR5 CCR5 NNP cord-021424-kocwsyi7 65 2 described describe VBN cord-021424-kocwsyi7 65 3 below below IN cord-021424-kocwsyi7 65 4 ( ( -LRB- cord-021424-kocwsyi7 65 5 Dean Dean NNP cord-021424-kocwsyi7 65 6 et et NNP cord-021424-kocwsyi7 65 7 al al NNP cord-021424-kocwsyi7 65 8 . . NNP cord-021424-kocwsyi7 65 9 , , , cord-021424-kocwsyi7 65 10 1996 1996 CD cord-021424-kocwsyi7 65 11 ; ; : cord-021424-kocwsyi7 65 12 Samson Samson NNP cord-021424-kocwsyi7 65 13 et et NNP cord-021424-kocwsyi7 65 14 al al NNP cord-021424-kocwsyi7 65 15 . . NNP cord-021424-kocwsyi7 65 16 , , , cord-021424-kocwsyi7 65 17 1996 1996 CD cord-021424-kocwsyi7 65 18 ) ) -RRB- cord-021424-kocwsyi7 65 19 . . . cord-021424-kocwsyi7 66 1 Genome genome NN cord-021424-kocwsyi7 66 2 - - HYPH cord-021424-kocwsyi7 66 3 wide wide JJ cord-021424-kocwsyi7 66 4 association association NN cord-021424-kocwsyi7 66 5 studies study NNS cord-021424-kocwsyi7 66 6 although although IN cord-021424-kocwsyi7 66 7 still still RB cord-021424-kocwsyi7 66 8 quite quite RB cord-021424-kocwsyi7 66 9 expensive expensive JJ cord-021424-kocwsyi7 66 10 are be VBP cord-021424-kocwsyi7 66 11 now now RB cord-021424-kocwsyi7 66 12 becoming become VBG cord-021424-kocwsyi7 66 13 feasible feasible JJ cord-021424-kocwsyi7 66 14 and and CC cord-021424-kocwsyi7 66 15 being be VBG cord-021424-kocwsyi7 66 16 used use VBN cord-021424-kocwsyi7 66 17 to to TO cord-021424-kocwsyi7 66 18 defi defi NNP cord-021424-kocwsyi7 66 19 ne ne NNP cord-021424-kocwsyi7 66 20 linkage linkage NN cord-021424-kocwsyi7 66 21 between between IN cord-021424-kocwsyi7 66 22 specifi specifi NNP cord-021424-kocwsyi7 66 23 c c NN cord-021424-kocwsyi7 66 24 markers marker NNS cord-021424-kocwsyi7 66 25 and and CC cord-021424-kocwsyi7 66 26 susceptibility susceptibility NN cord-021424-kocwsyi7 66 27 . . . cord-021424-kocwsyi7 67 1 These these DT cord-021424-kocwsyi7 67 2 linkage linkage NN cord-021424-kocwsyi7 67 3 studies study NNS cord-021424-kocwsyi7 67 4 depend depend VBP cord-021424-kocwsyi7 67 5 on on IN cord-021424-kocwsyi7 67 6 the the DT cord-021424-kocwsyi7 67 7 availability availability NN cord-021424-kocwsyi7 67 8 of of IN cord-021424-kocwsyi7 67 9 markers marker NNS cord-021424-kocwsyi7 67 10 and and CC cord-021424-kocwsyi7 67 11 the the DT cord-021424-kocwsyi7 67 12 density density NN cord-021424-kocwsyi7 67 13 of of IN cord-021424-kocwsyi7 67 14 these these DT cord-021424-kocwsyi7 67 15 markers marker NNS cord-021424-kocwsyi7 67 16 is be VBZ cord-021424-kocwsyi7 67 17 rapidly rapidly RB cord-021424-kocwsyi7 67 18 increasing increase VBG cord-021424-kocwsyi7 67 19 T T NNP cord-021424-kocwsyi7 67 20 A a NN cord-021424-kocwsyi7 67 21 B b NN cord-021424-kocwsyi7 67 22 L l NN cord-021424-kocwsyi7 67 23 E e NN cord-021424-kocwsyi7 67 24 1 1 CD cord-021424-kocwsyi7 67 25 0 0 CD cord-021424-kocwsyi7 67 26 7 7 CD cord-021424-kocwsyi7 67 27 . . . cord-021424-kocwsyi7 68 1 1 1 CD cord-021424-kocwsyi7 68 2 List list NN cord-021424-kocwsyi7 68 3 of of IN cord-021424-kocwsyi7 68 4 well well RB cord-021424-kocwsyi7 68 5 - - HYPH cord-021424-kocwsyi7 68 6 described describe VBN cord-021424-kocwsyi7 68 7 susceptibility susceptibility NN cord-021424-kocwsyi7 68 8 loci locus NNS cord-021424-kocwsyi7 68 9 for for IN cord-021424-kocwsyi7 68 10 resistance resistance NN cord-021424-kocwsyi7 68 11 or or CC cord-021424-kocwsyi7 68 12 susceptibility susceptibility NN cord-021424-kocwsyi7 68 13 to to IN cord-021424-kocwsyi7 68 14 infectious infectious JJ cord-021424-kocwsyi7 68 15 disease disease NN cord-021424-kocwsyi7 68 16 . . . cord-021424-kocwsyi7 69 1 Genes gene NNS cord-021424-kocwsyi7 69 2 References reference NNS cord-021424-kocwsyi7 69 3 with with IN cord-021424-kocwsyi7 69 4 the the DT cord-021424-kocwsyi7 69 5 large large JJ cord-021424-kocwsyi7 69 6 scale scale NN cord-021424-kocwsyi7 69 7 identifi identifi NN cord-021424-kocwsyi7 69 8 cation cation NNP cord-021424-kocwsyi7 69 9 of of IN cord-021424-kocwsyi7 69 10 new new NNP cord-021424-kocwsyi7 69 11 SNPs SNPs NNPS cord-021424-kocwsyi7 69 12 across across IN cord-021424-kocwsyi7 69 13 the the DT cord-021424-kocwsyi7 69 14 human human JJ cord-021424-kocwsyi7 69 15 genome genome NN cord-021424-kocwsyi7 69 16 . . . cord-021424-kocwsyi7 70 1 The the DT cord-021424-kocwsyi7 70 2 selection selection NN cord-021424-kocwsyi7 70 3 of of IN cord-021424-kocwsyi7 70 4 which which WDT cord-021424-kocwsyi7 70 5 SNPs snp NNS cord-021424-kocwsyi7 70 6 to to TO cord-021424-kocwsyi7 70 7 use use VB cord-021424-kocwsyi7 70 8 and and CC cord-021424-kocwsyi7 70 9 the the DT cord-021424-kocwsyi7 70 10 large large JJ cord-021424-kocwsyi7 70 11 numbers number NNS cord-021424-kocwsyi7 70 12 of of IN cord-021424-kocwsyi7 70 13 samples sample NNS cord-021424-kocwsyi7 70 14 needed need VBN cord-021424-kocwsyi7 70 15 to to TO cord-021424-kocwsyi7 70 16 generate generate VB cord-021424-kocwsyi7 70 17 statistically statistically RB cord-021424-kocwsyi7 70 18 significant significant JJ cord-021424-kocwsyi7 70 19 associations association NNS cord-021424-kocwsyi7 70 20 for for IN cord-021424-kocwsyi7 70 21 low low JJ cord-021424-kocwsyi7 70 22 penetrance penetrance NN cord-021424-kocwsyi7 70 23 alleles allele NNS cord-021424-kocwsyi7 70 24 are be VBP cord-021424-kocwsyi7 70 25 still still RB cord-021424-kocwsyi7 70 26 challenges challenge NNS cord-021424-kocwsyi7 70 27 . . . cord-021424-kocwsyi7 71 1 The the DT cord-021424-kocwsyi7 71 2 Haplotype Haplotype NNP cord-021424-kocwsyi7 71 3 MAP MAP NNP cord-021424-kocwsyi7 71 4 ( ( -LRB- cord-021424-kocwsyi7 71 5 HapMap hapmap NN cord-021424-kocwsyi7 71 6 ) ) -RRB- cord-021424-kocwsyi7 71 7 project project NN cord-021424-kocwsyi7 71 8 is be VBZ cord-021424-kocwsyi7 71 9 starting start VBG cord-021424-kocwsyi7 71 10 to to TO cord-021424-kocwsyi7 71 11 identify identify VB cord-021424-kocwsyi7 71 12 haplotypes haplotype NNS cord-021424-kocwsyi7 71 13 within within IN cord-021424-kocwsyi7 71 14 different different JJ cord-021424-kocwsyi7 71 15 population population NN cord-021424-kocwsyi7 71 16 groups group NNS cord-021424-kocwsyi7 71 17 and and CC cord-021424-kocwsyi7 71 18 together together RB cord-021424-kocwsyi7 71 19 with with IN cord-021424-kocwsyi7 71 20 improvements improvement NNS cord-021424-kocwsyi7 71 21 in in IN cord-021424-kocwsyi7 71 22 large large JJ cord-021424-kocwsyi7 71 23 scale scale NN cord-021424-kocwsyi7 71 24 genotyping genotyping NN cord-021424-kocwsyi7 71 25 technology technology NN cord-021424-kocwsyi7 71 26 and and CC cord-021424-kocwsyi7 71 27 bioinformatics bioinformatic NNS cord-021424-kocwsyi7 71 28 should should MD cord-021424-kocwsyi7 71 29 be be VB cord-021424-kocwsyi7 71 30 useful useful JJ cord-021424-kocwsyi7 71 31 in in IN cord-021424-kocwsyi7 71 32 studies study NNS cord-021424-kocwsyi7 71 33 of of IN cord-021424-kocwsyi7 71 34 complex complex JJ cord-021424-kocwsyi7 71 35 disease disease NN cord-021424-kocwsyi7 71 36 inheritance inheritance NN cord-021424-kocwsyi7 71 37 . . . cord-021424-kocwsyi7 72 1 Table table NN cord-021424-kocwsyi7 72 2 107 107 CD cord-021424-kocwsyi7 72 3 .1 .1 NFP cord-021424-kocwsyi7 72 4 summarizes summarize VBZ cord-021424-kocwsyi7 72 5 the the DT cord-021424-kocwsyi7 72 6 best well RBS cord-021424-kocwsyi7 72 7 studied study VBN cord-021424-kocwsyi7 72 8 genetic genetic JJ cord-021424-kocwsyi7 72 9 susceptibility susceptibility NN cord-021424-kocwsyi7 72 10 loci locus NNS cord-021424-kocwsyi7 72 11 for for IN cord-021424-kocwsyi7 72 12 response response NN cord-021424-kocwsyi7 72 13 to to IN cord-021424-kocwsyi7 72 14 different different JJ cord-021424-kocwsyi7 72 15 infectious infectious JJ cord-021424-kocwsyi7 72 16 agents agent NNS cord-021424-kocwsyi7 72 17 in in IN cord-021424-kocwsyi7 72 18 both both DT cord-021424-kocwsyi7 72 19 mouse mouse NN cord-021424-kocwsyi7 72 20 models model NNS cord-021424-kocwsyi7 72 21 and and CC cord-021424-kocwsyi7 72 22 human human JJ cord-021424-kocwsyi7 72 23 studies study NNS cord-021424-kocwsyi7 72 24 . . . cord-021424-kocwsyi7 73 1 One one CD cord-021424-kocwsyi7 73 2 of of IN cord-021424-kocwsyi7 73 3 the the DT cord-021424-kocwsyi7 73 4 classical classical JJ cord-021424-kocwsyi7 73 5 examples example NNS cord-021424-kocwsyi7 73 6 of of IN cord-021424-kocwsyi7 73 7 genetic genetic JJ cord-021424-kocwsyi7 73 8 susceptibility susceptibility NN cord-021424-kocwsyi7 73 9 to to IN cord-021424-kocwsyi7 73 10 infection infection NN cord-021424-kocwsyi7 73 11 is be VBZ cord-021424-kocwsyi7 73 12 the the DT cord-021424-kocwsyi7 73 13 role role NN cord-021424-kocwsyi7 73 14 of of IN cord-021424-kocwsyi7 73 15 the the DT cord-021424-kocwsyi7 73 16 hemaglobinopathies hemaglobinopathie NNS cord-021424-kocwsyi7 73 17 in in IN cord-021424-kocwsyi7 73 18 the the DT cord-021424-kocwsyi7 73 19 outcome outcome NN cord-021424-kocwsyi7 73 20 of of IN cord-021424-kocwsyi7 73 21 malaria malaria NN cord-021424-kocwsyi7 73 22 infection infection NN cord-021424-kocwsyi7 74 1 ( ( -LRB- cord-021424-kocwsyi7 74 2 Patrinos Patrinos NNP cord-021424-kocwsyi7 74 3 et et NNP cord-021424-kocwsyi7 74 4 al al NNP cord-021424-kocwsyi7 74 5 . . NNP cord-021424-kocwsyi7 74 6 , , , cord-021424-kocwsyi7 74 7 2005 2005 CD cord-021424-kocwsyi7 74 8 ) ) -RRB- cord-021424-kocwsyi7 74 9 . . . cord-021424-kocwsyi7 75 1 There there EX cord-021424-kocwsyi7 75 2 are be VBP cord-021424-kocwsyi7 75 3 also also RB cord-021424-kocwsyi7 75 4 certain certain JJ cord-021424-kocwsyi7 75 5 chromosomal chromosomal JJ cord-021424-kocwsyi7 75 6 regions region NNS cord-021424-kocwsyi7 75 7 and and CC cord-021424-kocwsyi7 75 8 families family NNS cord-021424-kocwsyi7 75 9 of of IN cord-021424-kocwsyi7 75 10 genes gene NNS cord-021424-kocwsyi7 75 11 that that WDT cord-021424-kocwsyi7 75 12 have have VBP cord-021424-kocwsyi7 75 13 attracted attract VBN cord-021424-kocwsyi7 75 14 attention attention NN cord-021424-kocwsyi7 75 15 in in IN cord-021424-kocwsyi7 75 16 terms term NNS cord-021424-kocwsyi7 75 17 of of IN cord-021424-kocwsyi7 75 18 searching search VBG cord-021424-kocwsyi7 75 19 for for IN cord-021424-kocwsyi7 75 20 susceptibility susceptibility NN cord-021424-kocwsyi7 75 21 alleles allele NNS cord-021424-kocwsyi7 75 22 or or CC cord-021424-kocwsyi7 75 23 polymorphisms polymorphism NNS cord-021424-kocwsyi7 75 24 . . . cord-021424-kocwsyi7 76 1 Because because IN cord-021424-kocwsyi7 76 2 the the DT cord-021424-kocwsyi7 76 3 TLR TLR NNP cord-021424-kocwsyi7 76 4 family family NN cord-021424-kocwsyi7 76 5 of of IN cord-021424-kocwsyi7 76 6 receptors receptor NNS cord-021424-kocwsyi7 76 7 plays play VBZ cord-021424-kocwsyi7 76 8 a a DT cord-021424-kocwsyi7 76 9 major major JJ cord-021424-kocwsyi7 76 10 role role NN cord-021424-kocwsyi7 76 11 in in IN cord-021424-kocwsyi7 76 12 recognizing recognize VBG cord-021424-kocwsyi7 76 13 pathogens pathogen NNS cord-021424-kocwsyi7 76 14 , , , cord-021424-kocwsyi7 76 15 it -PRON- PRP cord-021424-kocwsyi7 76 16 was be VBD cord-021424-kocwsyi7 76 17 speculated speculate VBN cord-021424-kocwsyi7 76 18 that that IN cord-021424-kocwsyi7 76 19 genetic genetic JJ cord-021424-kocwsyi7 76 20 variation variation NN cord-021424-kocwsyi7 76 21 in in IN cord-021424-kocwsyi7 76 22 these these DT cord-021424-kocwsyi7 76 23 receptors receptor NNS cord-021424-kocwsyi7 76 24 or or CC cord-021424-kocwsyi7 76 25 their -PRON- PRP$ cord-021424-kocwsyi7 76 26 signaling signal VBG cord-021424-kocwsyi7 76 27 pathways pathway NNS cord-021424-kocwsyi7 76 28 might may MD cord-021424-kocwsyi7 76 29 be be VB cord-021424-kocwsyi7 76 30 responsible responsible JJ cord-021424-kocwsyi7 76 31 for for IN cord-021424-kocwsyi7 76 32 some some DT cord-021424-kocwsyi7 76 33 susceptibility susceptibility NN cord-021424-kocwsyi7 76 34 phenotypes phenotype NNS cord-021424-kocwsyi7 76 35 ( ( -LRB- cord-021424-kocwsyi7 76 36 reviewed review VBN cord-021424-kocwsyi7 76 37 in in IN cord-021424-kocwsyi7 76 38 [ [ -LRB- cord-021424-kocwsyi7 76 39 Schroder Schroder NNP cord-021424-kocwsyi7 76 40 and and CC cord-021424-kocwsyi7 76 41 Schumann Schumann NNP cord-021424-kocwsyi7 76 42 , , , cord-021424-kocwsyi7 76 43 2005 2005 CD cord-021424-kocwsyi7 76 44 ] ] -RRB- cord-021424-kocwsyi7 76 45 ) ) -RRB- cord-021424-kocwsyi7 76 46 . . . cord-021424-kocwsyi7 77 1 One one CD cord-021424-kocwsyi7 77 2 of of IN cord-021424-kocwsyi7 77 3 the the DT cord-021424-kocwsyi7 77 4 best good JJS cord-021424-kocwsyi7 77 5 examples example NNS cord-021424-kocwsyi7 77 6 to to IN cord-021424-kocwsyi7 77 7 date date NN cord-021424-kocwsyi7 77 8 is be VBZ cord-021424-kocwsyi7 77 9 the the DT cord-021424-kocwsyi7 77 10 occurrence occurrence NN cord-021424-kocwsyi7 77 11 of of IN cord-021424-kocwsyi7 77 12 a a DT cord-021424-kocwsyi7 77 13 single single JJ cord-021424-kocwsyi7 77 14 polymorphism polymorphism NN cord-021424-kocwsyi7 77 15 in in IN cord-021424-kocwsyi7 77 16 the the DT cord-021424-kocwsyi7 77 17 region region NN cord-021424-kocwsyi7 77 18 of of IN cord-021424-kocwsyi7 77 19 the the DT cord-021424-kocwsyi7 77 20 human human JJ cord-021424-kocwsyi7 77 21 TLR4 TLR4 NNP cord-021424-kocwsyi7 77 22 gene gene NN cord-021424-kocwsyi7 77 23 encoding encode VBG cord-021424-kocwsyi7 77 24 the the DT cord-021424-kocwsyi7 77 25 extracellular extracellular JJ cord-021424-kocwsyi7 77 26 domain domain NN cord-021424-kocwsyi7 77 27 of of IN cord-021424-kocwsyi7 77 28 the the DT cord-021424-kocwsyi7 77 29 receptor receptor NN cord-021424-kocwsyi7 77 30 which which WDT cord-021424-kocwsyi7 77 31 confers confer VBZ cord-021424-kocwsyi7 77 32 reduced reduce VBN cord-021424-kocwsyi7 77 33 sensitivity sensitivity NN cord-021424-kocwsyi7 77 34 to to IN cord-021424-kocwsyi7 77 35 inhaled inhale VBN cord-021424-kocwsyi7 77 36 Escherichia Escherichia NNP cord-021424-kocwsyi7 77 37 coli coli NNS cord-021424-kocwsyi7 77 38 ( ( -LRB- cord-021424-kocwsyi7 77 39 E. E. NNP cord-021424-kocwsyi7 77 40 coli coli NNS cord-021424-kocwsyi7 77 41 ) ) -RRB- cord-021424-kocwsyi7 77 42 LPS LPS NNP cord-021424-kocwsyi7 77 43 ( ( -LRB- cord-021424-kocwsyi7 77 44 Arbour Arbour NNP cord-021424-kocwsyi7 77 45 et et NNP cord-021424-kocwsyi7 77 46 al al NNP cord-021424-kocwsyi7 77 47 . . NNP cord-021424-kocwsyi7 77 48 , , , cord-021424-kocwsyi7 77 49 2000 2000 CD cord-021424-kocwsyi7 77 50 ) ) -RRB- cord-021424-kocwsyi7 77 51 . . . cord-021424-kocwsyi7 78 1 Interestingly interestingly RB cord-021424-kocwsyi7 78 2 , , , cord-021424-kocwsyi7 78 3 when when WRB cord-021424-kocwsyi7 78 4 septic septic JJ cord-021424-kocwsyi7 78 5 shock shock NN cord-021424-kocwsyi7 78 6 patients patient NNS cord-021424-kocwsyi7 78 7 were be VBD cord-021424-kocwsyi7 78 8 compared compare VBN cord-021424-kocwsyi7 78 9 with with IN cord-021424-kocwsyi7 78 10 a a DT cord-021424-kocwsyi7 78 11 control control NN cord-021424-kocwsyi7 78 12 group group NN cord-021424-kocwsyi7 78 13 , , , cord-021424-kocwsyi7 78 14 these these DT cord-021424-kocwsyi7 78 15 lower lower RBR cord-021424-kocwsyi7 78 16 - - HYPH cord-021424-kocwsyi7 78 17 responding respond VBG cord-021424-kocwsyi7 78 18 alleles allele NNS cord-021424-kocwsyi7 78 19 were be VBD cord-021424-kocwsyi7 78 20 found find VBN cord-021424-kocwsyi7 78 21 only only RB cord-021424-kocwsyi7 78 22 in in IN cord-021424-kocwsyi7 78 23 the the DT cord-021424-kocwsyi7 78 24 septic septic JJ cord-021424-kocwsyi7 78 25 shock shock NN cord-021424-kocwsyi7 78 26 group group NN cord-021424-kocwsyi7 78 27 and and CC cord-021424-kocwsyi7 78 28 these these DT cord-021424-kocwsyi7 78 29 individuals individual NNS cord-021424-kocwsyi7 78 30 had have VBD cord-021424-kocwsyi7 78 31 a a DT cord-021424-kocwsyi7 78 32 higher high JJR cord-021424-kocwsyi7 78 33 incidence incidence NN cord-021424-kocwsyi7 78 34 of of IN cord-021424-kocwsyi7 78 35 Gramnegative gramnegative JJ cord-021424-kocwsyi7 78 36 bacterial bacterial JJ cord-021424-kocwsyi7 78 37 infection infection NN cord-021424-kocwsyi7 79 1 ( ( -LRB- cord-021424-kocwsyi7 79 2 Feterowski Feterowski NNP cord-021424-kocwsyi7 79 3 et et NNP cord-021424-kocwsyi7 79 4 al al NNP cord-021424-kocwsyi7 79 5 . . NNP cord-021424-kocwsyi7 79 6 , , , cord-021424-kocwsyi7 79 7 2003 2003 CD cord-021424-kocwsyi7 79 8 ) ) -RRB- cord-021424-kocwsyi7 79 9 . . . cord-021424-kocwsyi7 80 1 Such such JJ cord-021424-kocwsyi7 80 2 studies study NNS cord-021424-kocwsyi7 80 3 need need VBP cord-021424-kocwsyi7 80 4 further further JJ cord-021424-kocwsyi7 80 5 confi confi NN cord-021424-kocwsyi7 80 6 rmation rmation NN cord-021424-kocwsyi7 80 7 since since IN cord-021424-kocwsyi7 80 8 there there EX cord-021424-kocwsyi7 80 9 are be VBP cord-021424-kocwsyi7 80 10 also also RB cord-021424-kocwsyi7 80 11 a a DT cord-021424-kocwsyi7 80 12 number number NN cord-021424-kocwsyi7 80 13 of of IN cord-021424-kocwsyi7 80 14 studies study NNS cord-021424-kocwsyi7 80 15 that that WDT cord-021424-kocwsyi7 80 16 failed fail VBD cord-021424-kocwsyi7 80 17 to to TO cord-021424-kocwsyi7 80 18 fi fi VB cord-021424-kocwsyi7 80 19 nd nd NNP cord-021424-kocwsyi7 80 20 any any DT cord-021424-kocwsyi7 80 21 linkage linkage NN cord-021424-kocwsyi7 80 22 between between IN cord-021424-kocwsyi7 80 23 TLR4 TLR4 NNP cord-021424-kocwsyi7 80 24 mutations mutation NNS cord-021424-kocwsyi7 80 25 and and CC cord-021424-kocwsyi7 80 26 response response NN cord-021424-kocwsyi7 80 27 to to IN cord-021424-kocwsyi7 80 28 various various JJ cord-021424-kocwsyi7 80 29 infections infection NNS cord-021424-kocwsyi7 80 30 ( ( -LRB- cord-021424-kocwsyi7 80 31 Schroder Schroder NNP cord-021424-kocwsyi7 80 32 and and CC cord-021424-kocwsyi7 80 33 Schumann Schumann NNP cord-021424-kocwsyi7 80 34 , , , cord-021424-kocwsyi7 80 35 2005 2005 CD cord-021424-kocwsyi7 80 36 ) ) -RRB- cord-021424-kocwsyi7 80 37 . . . cord-021424-kocwsyi7 81 1 There there EX cord-021424-kocwsyi7 81 2 is be VBZ cord-021424-kocwsyi7 81 3 also also RB cord-021424-kocwsyi7 81 4 enormous enormous JJ cord-021424-kocwsyi7 81 5 variation variation NN cord-021424-kocwsyi7 81 6 in in IN cord-021424-kocwsyi7 81 7 the the DT cord-021424-kocwsyi7 81 8 response response NN cord-021424-kocwsyi7 81 9 of of IN cord-021424-kocwsyi7 81 10 individuals individual NNS cord-021424-kocwsyi7 81 11 to to IN cord-021424-kocwsyi7 81 12 LPS LPS NNP cord-021424-kocwsyi7 81 13 even even RB cord-021424-kocwsyi7 81 14 in in IN cord-021424-kocwsyi7 81 15 the the DT cord-021424-kocwsyi7 81 16 absence absence NN cord-021424-kocwsyi7 81 17 of of IN cord-021424-kocwsyi7 81 18 TLR4 TLR4 NNP cord-021424-kocwsyi7 81 19 mutations mutation NNS cord-021424-kocwsyi7 81 20 implying imply VBG cord-021424-kocwsyi7 81 21 that that IN cord-021424-kocwsyi7 81 22 variation variation NN cord-021424-kocwsyi7 81 23 may may MD cord-021424-kocwsyi7 81 24 occur occur VB cord-021424-kocwsyi7 81 25 in in IN cord-021424-kocwsyi7 81 26 other other JJ cord-021424-kocwsyi7 81 27 components component NNS cord-021424-kocwsyi7 81 28 of of IN cord-021424-kocwsyi7 81 29 the the DT cord-021424-kocwsyi7 81 30 TLR4 TLR4 NNP cord-021424-kocwsyi7 81 31 signaling signal VBG cord-021424-kocwsyi7 81 32 system system NN cord-021424-kocwsyi7 81 33 . . . cord-021424-kocwsyi7 82 1 An an DT cord-021424-kocwsyi7 82 2 example example NN cord-021424-kocwsyi7 82 3 of of IN cord-021424-kocwsyi7 82 4 this this DT cord-021424-kocwsyi7 82 5 is be VBZ cord-021424-kocwsyi7 82 6 the the DT cord-021424-kocwsyi7 82 7 link link NN cord-021424-kocwsyi7 82 8 between between IN cord-021424-kocwsyi7 82 9 IRAK4 IRAK4 NNP cord-021424-kocwsyi7 82 10 mutations mutation NNS cord-021424-kocwsyi7 82 11 and and CC cord-021424-kocwsyi7 82 12 increased increase VBN cord-021424-kocwsyi7 82 13 susceptibility susceptibility NN cord-021424-kocwsyi7 82 14 to to IN cord-021424-kocwsyi7 82 15 infection infection NN cord-021424-kocwsyi7 82 16 with with IN cord-021424-kocwsyi7 82 17 pyogenic pyogenic JJ cord-021424-kocwsyi7 82 18 bacteria bacteria NNS cord-021424-kocwsyi7 82 19 ( ( -LRB- cord-021424-kocwsyi7 82 20 Picard Picard NNP cord-021424-kocwsyi7 82 21 et et NNP cord-021424-kocwsyi7 82 22 al al NNP cord-021424-kocwsyi7 82 23 . . NNP cord-021424-kocwsyi7 82 24 , , , cord-021424-kocwsyi7 82 25 2003 2003 CD cord-021424-kocwsyi7 82 26 ) ) -RRB- cord-021424-kocwsyi7 82 27 . . . cord-021424-kocwsyi7 83 1 Variation variation NN cord-021424-kocwsyi7 83 2 in in IN cord-021424-kocwsyi7 83 3 other other JJ cord-021424-kocwsyi7 83 4 TLR TLR NNP cord-021424-kocwsyi7 83 5 genes gene NNS cord-021424-kocwsyi7 83 6 has have VBZ cord-021424-kocwsyi7 83 7 also also RB cord-021424-kocwsyi7 83 8 been be VBN cord-021424-kocwsyi7 83 9 associated associate VBN cord-021424-kocwsyi7 83 10 with with IN cord-021424-kocwsyi7 83 11 disease disease NN cord-021424-kocwsyi7 83 12 susceptibility susceptibility NN cord-021424-kocwsyi7 83 13 . . . cord-021424-kocwsyi7 84 1 For for IN cord-021424-kocwsyi7 84 2 example example NN cord-021424-kocwsyi7 84 3 , , , cord-021424-kocwsyi7 84 4 a a DT cord-021424-kocwsyi7 84 5 mutation mutation NN cord-021424-kocwsyi7 84 6 in in IN cord-021424-kocwsyi7 84 7 the the DT cord-021424-kocwsyi7 84 8 extracellular extracellular JJ cord-021424-kocwsyi7 84 9 domain domain NN cord-021424-kocwsyi7 84 10 of of IN cord-021424-kocwsyi7 84 11 TLR2 TLR2 NNP cord-021424-kocwsyi7 84 12 is be VBZ cord-021424-kocwsyi7 84 13 linked link VBN cord-021424-kocwsyi7 84 14 to to IN cord-021424-kocwsyi7 84 15 susceptibility susceptibility NN cord-021424-kocwsyi7 84 16 to to IN cord-021424-kocwsyi7 84 17 leprosy leprosy NN cord-021424-kocwsyi7 85 1 ( ( -LRB- cord-021424-kocwsyi7 85 2 Alcais Alcais NNP cord-021424-kocwsyi7 85 3 et et NNP cord-021424-kocwsyi7 85 4 al al NNP cord-021424-kocwsyi7 85 5 . . NNP cord-021424-kocwsyi7 85 6 , , , cord-021424-kocwsyi7 85 7 2005 2005 CD cord-021424-kocwsyi7 85 8 ) ) -RRB- cord-021424-kocwsyi7 85 9 and and CC cord-021424-kocwsyi7 85 10 a a DT cord-021424-kocwsyi7 85 11 mutation mutation NN cord-021424-kocwsyi7 85 12 in in IN cord-021424-kocwsyi7 85 13 TLR5 TLR5 NNP cord-021424-kocwsyi7 85 14 increases increase NNS cord-021424-kocwsyi7 85 15 susceptibility susceptibility NN cord-021424-kocwsyi7 85 16 to to IN cord-021424-kocwsyi7 85 17 Legionella Legionella NNP cord-021424-kocwsyi7 85 18 . . . cord-021424-kocwsyi7 86 1 Taken take VBN cord-021424-kocwsyi7 86 2 together together RB cord-021424-kocwsyi7 86 3 these these DT cord-021424-kocwsyi7 86 4 data datum NNS cord-021424-kocwsyi7 86 5 support support VBP cord-021424-kocwsyi7 86 6 the the DT cord-021424-kocwsyi7 86 7 idea idea NN cord-021424-kocwsyi7 86 8 that that DT cord-021424-kocwsyi7 86 9 variation variation NN cord-021424-kocwsyi7 86 10 in in IN cord-021424-kocwsyi7 86 11 the the DT cord-021424-kocwsyi7 86 12 innate innate JJ cord-021424-kocwsyi7 86 13 immune immune JJ cord-021424-kocwsyi7 86 14 recognition recognition NN cord-021424-kocwsyi7 86 15 of of IN cord-021424-kocwsyi7 86 16 pathogens pathogen NNS cord-021424-kocwsyi7 86 17 play play VBP cord-021424-kocwsyi7 86 18 an an DT cord-021424-kocwsyi7 86 19 important important JJ cord-021424-kocwsyi7 86 20 part part NN cord-021424-kocwsyi7 86 21 in in IN cord-021424-kocwsyi7 86 22 governing govern VBG cord-021424-kocwsyi7 86 23 susceptibility susceptibility NN cord-021424-kocwsyi7 86 24 to to IN cord-021424-kocwsyi7 86 25 an an DT cord-021424-kocwsyi7 86 26 array array NN cord-021424-kocwsyi7 86 27 of of IN cord-021424-kocwsyi7 86 28 infectious infectious JJ cord-021424-kocwsyi7 86 29 diseases disease NNS cord-021424-kocwsyi7 86 30 . . . cord-021424-kocwsyi7 87 1 However however RB cord-021424-kocwsyi7 87 2 , , , cord-021424-kocwsyi7 87 3 caution caution NN cord-021424-kocwsyi7 87 4 needs need VBZ cord-021424-kocwsyi7 87 5 to to TO cord-021424-kocwsyi7 87 6 be be VB cord-021424-kocwsyi7 87 7 exercised exercise VBN cord-021424-kocwsyi7 87 8 until until IN cord-021424-kocwsyi7 87 9 larger large JJR cord-021424-kocwsyi7 87 10 population population NN cord-021424-kocwsyi7 87 11 groups group NNS cord-021424-kocwsyi7 87 12 have have VBP cord-021424-kocwsyi7 87 13 been be VBN cord-021424-kocwsyi7 87 14 studied study VBN cord-021424-kocwsyi7 87 15 . . . cord-021424-kocwsyi7 88 1 The the DT cord-021424-kocwsyi7 88 2 extensive extensive JJ cord-021424-kocwsyi7 88 3 polymorphism polymorphism NN cord-021424-kocwsyi7 88 4 at at IN cord-021424-kocwsyi7 88 5 the the DT cord-021424-kocwsyi7 88 6 chromosomal chromosomal JJ cord-021424-kocwsyi7 88 7 regions region NNS cord-021424-kocwsyi7 88 8 encoding encode VBG cord-021424-kocwsyi7 88 9 major major JJ cord-021424-kocwsyi7 88 10 histocompatibility histocompatibility NN cord-021424-kocwsyi7 88 11 complex complex NN cord-021424-kocwsyi7 88 12 ( ( -LRB- cord-021424-kocwsyi7 88 13 MHC MHC NNP cord-021424-kocwsyi7 88 14 ) ) -RRB- cord-021424-kocwsyi7 88 15 proteins protein NNS cord-021424-kocwsyi7 88 16 is be VBZ cord-021424-kocwsyi7 88 17 thought think VBN cord-021424-kocwsyi7 88 18 to to TO cord-021424-kocwsyi7 88 19 have have VB cord-021424-kocwsyi7 88 20 arisen arise VBN cord-021424-kocwsyi7 88 21 through through IN cord-021424-kocwsyi7 88 22 natural natural JJ cord-021424-kocwsyi7 88 23 selection selection NN cord-021424-kocwsyi7 88 24 in in IN cord-021424-kocwsyi7 88 25 response response NN cord-021424-kocwsyi7 88 26 to to IN cord-021424-kocwsyi7 88 27 selective selective JJ cord-021424-kocwsyi7 88 28 pressure pressure NN cord-021424-kocwsyi7 88 29 from from IN cord-021424-kocwsyi7 88 30 infectious infectious JJ cord-021424-kocwsyi7 88 31 disease disease NN cord-021424-kocwsyi7 88 32 . . . cord-021424-kocwsyi7 89 1 Although although IN cord-021424-kocwsyi7 89 2 human human JJ cord-021424-kocwsyi7 89 3 leukocyte leukocyte NN cord-021424-kocwsyi7 89 4 antigen antigen NN cord-021424-kocwsyi7 89 5 ( ( -LRB- cord-021424-kocwsyi7 89 6 HLA HLA NNP cord-021424-kocwsyi7 89 7 ) ) -RRB- cord-021424-kocwsyi7 89 8 association association NN cord-021424-kocwsyi7 89 9 with with IN cord-021424-kocwsyi7 89 10 resistance resistance NN cord-021424-kocwsyi7 89 11 or or CC cord-021424-kocwsyi7 89 12 susceptibility susceptibility NN cord-021424-kocwsyi7 89 13 to to IN cord-021424-kocwsyi7 89 14 infectious infectious JJ cord-021424-kocwsyi7 89 15 disease disease NN cord-021424-kocwsyi7 89 16 has have VBZ cord-021424-kocwsyi7 89 17 been be VBN cord-021424-kocwsyi7 89 18 diffi diffi NNP cord-021424-kocwsyi7 89 19 cult cult NN cord-021424-kocwsyi7 89 20 to to TO cord-021424-kocwsyi7 89 21 identify identify VB cord-021424-kocwsyi7 89 22 because because IN cord-021424-kocwsyi7 89 23 of of IN cord-021424-kocwsyi7 89 24 the the DT cord-021424-kocwsyi7 89 25 complex complex JJ cord-021424-kocwsyi7 89 26 array array NN cord-021424-kocwsyi7 89 27 of of IN cord-021424-kocwsyi7 89 28 antigenic antigenic JJ cord-021424-kocwsyi7 89 29 epitopes epitope NNS cord-021424-kocwsyi7 89 30 involved involve VBN cord-021424-kocwsyi7 89 31 , , , cord-021424-kocwsyi7 89 32 a a DT cord-021424-kocwsyi7 89 33 number number NN cord-021424-kocwsyi7 89 34 of of IN cord-021424-kocwsyi7 89 35 studies study NNS cord-021424-kocwsyi7 89 36 have have VBP cord-021424-kocwsyi7 89 37 implicated implicate VBN cord-021424-kocwsyi7 89 38 this this DT cord-021424-kocwsyi7 89 39 locus locus NN cord-021424-kocwsyi7 89 40 in in IN cord-021424-kocwsyi7 89 41 genetic genetic JJ cord-021424-kocwsyi7 89 42 susceptibility susceptibility NN cord-021424-kocwsyi7 89 43 to to IN cord-021424-kocwsyi7 89 44 infectious infectious JJ cord-021424-kocwsyi7 89 45 disease disease NN cord-021424-kocwsyi7 89 46 ( ( -LRB- cord-021424-kocwsyi7 89 47 Ghodke Ghodke NNP cord-021424-kocwsyi7 89 48 et et NNP cord-021424-kocwsyi7 89 49 al al NNP cord-021424-kocwsyi7 89 50 . . NNP cord-021424-kocwsyi7 89 51 , , , cord-021424-kocwsyi7 89 52 2005 2005 CD cord-021424-kocwsyi7 89 53 ; ; : cord-021424-kocwsyi7 89 54 Little little JJ cord-021424-kocwsyi7 89 55 and and CC cord-021424-kocwsyi7 89 56 Parham Parham NNP cord-021424-kocwsyi7 89 57 , , , cord-021424-kocwsyi7 89 58 1999 1999 CD cord-021424-kocwsyi7 89 59 ) ) -RRB- cord-021424-kocwsyi7 89 60 . . . cord-021424-kocwsyi7 90 1 MHC MHC NNP cord-021424-kocwsyi7 90 2 molecules molecule NNS cord-021424-kocwsyi7 90 3 fall fall VBP cord-021424-kocwsyi7 90 4 into into IN cord-021424-kocwsyi7 90 5 two two CD cord-021424-kocwsyi7 90 6 classes class NNS cord-021424-kocwsyi7 90 7 , , . cord-021424-kocwsyi7 91 1 Class class NN cord-021424-kocwsyi7 91 2 I -PRON- PRP cord-021424-kocwsyi7 91 3 that that WDT cord-021424-kocwsyi7 91 4 present present VBP cord-021424-kocwsyi7 91 5 foreign foreign JJ cord-021424-kocwsyi7 91 6 antigens antigen NNS cord-021424-kocwsyi7 91 7 to to IN cord-021424-kocwsyi7 91 8 CD8 CD8 NNP cord-021424-kocwsyi7 91 9 ϩ ϩ NNP cord-021424-kocwsyi7 91 10 cytotoxic cytotoxic JJ cord-021424-kocwsyi7 91 11 T T NNP cord-021424-kocwsyi7 91 12 cells cell NNS cord-021424-kocwsyi7 91 13 and and CC cord-021424-kocwsyi7 91 14 Class Class NNP cord-021424-kocwsyi7 91 15 II II NNP cord-021424-kocwsyi7 91 16 that that WDT cord-021424-kocwsyi7 91 17 play play VBP cord-021424-kocwsyi7 91 18 a a DT cord-021424-kocwsyi7 91 19 similar similar JJ cord-021424-kocwsyi7 91 20 role role NN cord-021424-kocwsyi7 91 21 for for IN cord-021424-kocwsyi7 91 22 CD4 CD4 NNP cord-021424-kocwsyi7 91 23 ϩ ϩ NNP cord-021424-kocwsyi7 91 24 helper helper NN cord-021424-kocwsyi7 91 25 T T NNP cord-021424-kocwsyi7 91 26 cells cell NNS cord-021424-kocwsyi7 91 27 . . . cord-021424-kocwsyi7 92 1 Variation variation NN cord-021424-kocwsyi7 92 2 in in IN cord-021424-kocwsyi7 92 3 specifi specifi NN cord-021424-kocwsyi7 92 4 c c NN cord-021424-kocwsyi7 92 5 Class class NN cord-021424-kocwsyi7 93 1 I -PRON- PRP cord-021424-kocwsyi7 93 2 genes gene NNS cord-021424-kocwsyi7 93 3 has have VBZ cord-021424-kocwsyi7 93 4 been be VBN cord-021424-kocwsyi7 93 5 shown show VBN cord-021424-kocwsyi7 93 6 to to TO cord-021424-kocwsyi7 93 7 confer confer VB cord-021424-kocwsyi7 93 8 susceptibility susceptibility NN cord-021424-kocwsyi7 93 9 to to IN cord-021424-kocwsyi7 93 10 pulmonary pulmonary JJ cord-021424-kocwsyi7 93 11 tuberculosis tuberculosis NN cord-021424-kocwsyi7 93 12 and and CC cord-021424-kocwsyi7 93 13 to to IN cord-021424-kocwsyi7 93 14 HIV HIV NNP cord-021424-kocwsyi7 93 15 whereas whereas IN cord-021424-kocwsyi7 93 16 mutations mutation NNS cord-021424-kocwsyi7 93 17 in in IN cord-021424-kocwsyi7 93 18 other other JJ cord-021424-kocwsyi7 93 19 Class class NN cord-021424-kocwsyi7 93 20 I -PRON- PRP cord-021424-kocwsyi7 93 21 genes gene NNS cord-021424-kocwsyi7 93 22 confer confer VBP cord-021424-kocwsyi7 93 23 resistance resistance NN cord-021424-kocwsyi7 93 24 to to IN cord-021424-kocwsyi7 93 25 HIV HIV NNP cord-021424-kocwsyi7 93 26 and and CC cord-021424-kocwsyi7 93 27 to to IN cord-021424-kocwsyi7 93 28 severe severe JJ cord-021424-kocwsyi7 93 29 malaria malaria NN cord-021424-kocwsyi7 93 30 . . . cord-021424-kocwsyi7 94 1 Class class NN cord-021424-kocwsyi7 94 2 II ii CD cord-021424-kocwsyi7 94 3 mutations mutation NNS cord-021424-kocwsyi7 94 4 that that WDT cord-021424-kocwsyi7 94 5 confer confer VBP cord-021424-kocwsyi7 94 6 resistance resistance NN cord-021424-kocwsyi7 94 7 to to IN cord-021424-kocwsyi7 94 8 hepatitis hepatitis NNP cord-021424-kocwsyi7 94 9 B B NNP cord-021424-kocwsyi7 94 10 or or CC cord-021424-kocwsyi7 94 11 hepatitis hepatitis NN cord-021424-kocwsyi7 94 12 C C NNP cord-021424-kocwsyi7 94 13 have have VBP cord-021424-kocwsyi7 94 14 been be VBN cord-021424-kocwsyi7 94 15 identifi identifi VBN cord-021424-kocwsyi7 94 16 ed ed NN cord-021424-kocwsyi7 94 17 and and CC cord-021424-kocwsyi7 94 18 susceptibility susceptibility NN cord-021424-kocwsyi7 94 19 to to IN cord-021424-kocwsyi7 94 20 typhoid typhoid NN cord-021424-kocwsyi7 94 21 fever fever NN cord-021424-kocwsyi7 94 22 and and CC cord-021424-kocwsyi7 94 23 leprosy leprosy NN cord-021424-kocwsyi7 94 24 are be VBP cord-021424-kocwsyi7 94 25 also also RB cord-021424-kocwsyi7 94 26 associated associate VBN cord-021424-kocwsyi7 94 27 with with IN cord-021424-kocwsyi7 94 28 specifi specifi NNP cord-021424-kocwsyi7 94 29 c c NNP cord-021424-kocwsyi7 94 30 Class Class NNP cord-021424-kocwsyi7 94 31 II II NNP cord-021424-kocwsyi7 94 32 mutations mutation NNS cord-021424-kocwsyi7 94 33 . . . cord-021424-kocwsyi7 95 1 Further further JJ cord-021424-kocwsyi7 95 2 molecular molecular JJ cord-021424-kocwsyi7 95 3 analysis analysis NN cord-021424-kocwsyi7 95 4 of of IN cord-021424-kocwsyi7 95 5 these these DT cord-021424-kocwsyi7 95 6 and and CC cord-021424-kocwsyi7 95 7 other other JJ cord-021424-kocwsyi7 95 8 associations association NNS cord-021424-kocwsyi7 95 9 may may MD cord-021424-kocwsyi7 95 10 in in IN cord-021424-kocwsyi7 95 11 the the DT cord-021424-kocwsyi7 95 12 future future NN cord-021424-kocwsyi7 95 13 have have VBP cord-021424-kocwsyi7 95 14 an an DT cord-021424-kocwsyi7 95 15 impact impact NN cord-021424-kocwsyi7 95 16 on on IN cord-021424-kocwsyi7 95 17 the the DT cord-021424-kocwsyi7 95 18 development development NN cord-021424-kocwsyi7 95 19 of of IN cord-021424-kocwsyi7 95 20 new new JJ cord-021424-kocwsyi7 95 21 vaccines vaccine NNS cord-021424-kocwsyi7 95 22 and and CC cord-021424-kocwsyi7 95 23 immunotherapeutics immunotherapeutic NNS cord-021424-kocwsyi7 95 24 . . . cord-021424-kocwsyi7 96 1 To to IN cord-021424-kocwsyi7 96 2 date date NN cord-021424-kocwsyi7 96 3 the the DT cord-021424-kocwsyi7 96 4 most most RBS cord-021424-kocwsyi7 96 5 successful successful JJ cord-021424-kocwsyi7 96 6 manner manner NN cord-021424-kocwsyi7 96 7 of of IN cord-021424-kocwsyi7 96 8 identifying identify VBG cord-021424-kocwsyi7 96 9 susceptibility susceptibility NN cord-021424-kocwsyi7 96 10 genes gene NNS cord-021424-kocwsyi7 96 11 in in IN cord-021424-kocwsyi7 96 12 human human JJ cord-021424-kocwsyi7 96 13 populations population NNS cord-021424-kocwsyi7 96 14 has have VBZ cord-021424-kocwsyi7 96 15 been be VBN cord-021424-kocwsyi7 96 16 the the DT cord-021424-kocwsyi7 96 17 candidate candidate NN cord-021424-kocwsyi7 96 18 gene gene NN cord-021424-kocwsyi7 96 19 approach approach NN cord-021424-kocwsyi7 96 20 . . . cord-021424-kocwsyi7 97 1 Candidate candidate NN cord-021424-kocwsyi7 97 2 genes gene NNS cord-021424-kocwsyi7 97 3 have have VBP cord-021424-kocwsyi7 97 4 emerged emerge VBN cord-021424-kocwsyi7 97 5 from from IN cord-021424-kocwsyi7 97 6 many many JJ cord-021424-kocwsyi7 97 7 sources source NNS cord-021424-kocwsyi7 97 8 including include VBG cord-021424-kocwsyi7 97 9 mouse mouse NN cord-021424-kocwsyi7 97 10 genetic genetic JJ cord-021424-kocwsyi7 97 11 studies study NNS cord-021424-kocwsyi7 97 12 as as RB cord-021424-kocwsyi7 97 13 well well RB cord-021424-kocwsyi7 97 14 as as IN cord-021424-kocwsyi7 97 15 biochemical biochemical JJ cord-021424-kocwsyi7 97 16 and and CC cord-021424-kocwsyi7 97 17 function function VBP cord-021424-kocwsyi7 97 18 dissection dissection NN cord-021424-kocwsyi7 97 19 of of IN cord-021424-kocwsyi7 97 20 the the DT cord-021424-kocwsyi7 97 21 immune immune JJ cord-021424-kocwsyi7 97 22 system system NN cord-021424-kocwsyi7 97 23 . . . cord-021424-kocwsyi7 98 1 Once once RB cord-021424-kocwsyi7 98 2 a a DT cord-021424-kocwsyi7 98 3 candidate candidate NN cord-021424-kocwsyi7 98 4 gene gene NN cord-021424-kocwsyi7 98 5 is be VBZ cord-021424-kocwsyi7 98 6 identifi identifi NNP cord-021424-kocwsyi7 98 7 ed ed NNP cord-021424-kocwsyi7 98 8 , , , cord-021424-kocwsyi7 98 9 the the DT cord-021424-kocwsyi7 98 10 chromosomal chromosomal JJ cord-021424-kocwsyi7 98 11 region region NN cord-021424-kocwsyi7 98 12 spanning span VBG cord-021424-kocwsyi7 98 13 this this DT cord-021424-kocwsyi7 98 14 gene gene NN cord-021424-kocwsyi7 98 15 in in IN cord-021424-kocwsyi7 98 16 the the DT cord-021424-kocwsyi7 98 17 human human JJ cord-021424-kocwsyi7 98 18 genome genome NN cord-021424-kocwsyi7 98 19 is be VBZ cord-021424-kocwsyi7 98 20 then then RB cord-021424-kocwsyi7 98 21 scanned scan VBN cord-021424-kocwsyi7 98 22 for for IN cord-021424-kocwsyi7 98 23 the the DT cord-021424-kocwsyi7 98 24 occurrence occurrence NN cord-021424-kocwsyi7 98 25 of of IN cord-021424-kocwsyi7 98 26 specifi specifi NNP cord-021424-kocwsyi7 98 27 c c NN cord-021424-kocwsyi7 98 28 mutations mutation NNS cord-021424-kocwsyi7 98 29 or or CC cord-021424-kocwsyi7 98 30 for for IN cord-021424-kocwsyi7 98 31 functional functional JJ cord-021424-kocwsyi7 98 32 polymorphisms polymorphism NNS cord-021424-kocwsyi7 98 33 in in IN cord-021424-kocwsyi7 98 34 casecontrol casecontrol NNP cord-021424-kocwsyi7 98 35 studies study NNS cord-021424-kocwsyi7 98 36 across across IN cord-021424-kocwsyi7 98 37 populations population NNS cord-021424-kocwsyi7 98 38 or or CC cord-021424-kocwsyi7 98 39 in in IN cord-021424-kocwsyi7 98 40 linkage linkage NN cord-021424-kocwsyi7 98 41 studies study NNS cord-021424-kocwsyi7 98 42 in in IN cord-021424-kocwsyi7 98 43 family family NN cord-021424-kocwsyi7 98 44 groups group NNS cord-021424-kocwsyi7 98 45 . . . cord-021424-kocwsyi7 99 1 Such such JJ cord-021424-kocwsyi7 99 2 studies study NNS cord-021424-kocwsyi7 99 3 have have VBP cord-021424-kocwsyi7 99 4 identifi identifi VBN cord-021424-kocwsyi7 99 5 ed ed NNP cord-021424-kocwsyi7 99 6 a a DT cord-021424-kocwsyi7 99 7 number number NN cord-021424-kocwsyi7 99 8 of of IN cord-021424-kocwsyi7 99 9 well well RB cord-021424-kocwsyi7 99 10 described describe VBN cord-021424-kocwsyi7 99 11 susceptibility susceptibility NN cord-021424-kocwsyi7 99 12 loci locus NNS cord-021424-kocwsyi7 99 13 for for IN cord-021424-kocwsyi7 99 14 infection infection NN cord-021424-kocwsyi7 99 15 with with IN cord-021424-kocwsyi7 99 16 various various JJ cord-021424-kocwsyi7 99 17 pathogens pathogen NNS cord-021424-kocwsyi7 99 18 . . . cord-021424-kocwsyi7 100 1 One one CD cord-021424-kocwsyi7 100 2 of of IN cord-021424-kocwsyi7 100 3 the the DT cord-021424-kocwsyi7 100 4 most most RBS cord-021424-kocwsyi7 100 5 heralded herald VBN cord-021424-kocwsyi7 100 6 example example NN cord-021424-kocwsyi7 100 7 was be VBD cord-021424-kocwsyi7 100 8 the the DT cord-021424-kocwsyi7 100 9 identifi identifi NNP cord-021424-kocwsyi7 100 10 cation cation NN cord-021424-kocwsyi7 100 11 of of IN cord-021424-kocwsyi7 100 12 a a DT cord-021424-kocwsyi7 100 13 deletion deletion NN cord-021424-kocwsyi7 100 14 in in IN cord-021424-kocwsyi7 100 15 the the DT cord-021424-kocwsyi7 100 16 chemokine chemokine NN cord-021424-kocwsyi7 100 17 receptor receptor NN cord-021424-kocwsyi7 100 18 , , , cord-021424-kocwsyi7 100 19 CCR5 CCR5 NNP cord-021424-kocwsyi7 100 20 , , , cord-021424-kocwsyi7 100 21 which which WDT cord-021424-kocwsyi7 100 22 was be VBD cord-021424-kocwsyi7 100 23 shown show VBN cord-021424-kocwsyi7 100 24 to to TO cord-021424-kocwsyi7 100 25 confer confer VB cord-021424-kocwsyi7 100 26 resistance resistance NN cord-021424-kocwsyi7 100 27 to to IN cord-021424-kocwsyi7 100 28 HIV HIV NNP cord-021424-kocwsyi7 100 29 infection infection NN cord-021424-kocwsyi7 101 1 ( ( -LRB- cord-021424-kocwsyi7 101 2 Dean Dean NNP cord-021424-kocwsyi7 101 3 et et NNP cord-021424-kocwsyi7 101 4 al al NNP cord-021424-kocwsyi7 101 5 . . . cord-021424-kocwsyi7 102 1 , , , cord-021424-kocwsyi7 102 2 1996 1996 CD cord-021424-kocwsyi7 102 3 ; ; : cord-021424-kocwsyi7 102 4 Samson Samson NNP cord-021424-kocwsyi7 102 5 et et NNP cord-021424-kocwsyi7 102 6 al al NNP cord-021424-kocwsyi7 102 7 . . NNP cord-021424-kocwsyi7 102 8 , , , cord-021424-kocwsyi7 102 9 1996 1996 CD cord-021424-kocwsyi7 102 10 ) ) -RRB- cord-021424-kocwsyi7 102 11 . . . cord-021424-kocwsyi7 103 1 Biochemically biochemically RB cord-021424-kocwsyi7 103 2 , , , cord-021424-kocwsyi7 103 3 this this DT cord-021424-kocwsyi7 103 4 can can MD cord-021424-kocwsyi7 103 5 be be VB cord-021424-kocwsyi7 103 6 explained explain VBN cord-021424-kocwsyi7 103 7 by by IN cord-021424-kocwsyi7 103 8 the the DT cord-021424-kocwsyi7 103 9 fact fact NN cord-021424-kocwsyi7 103 10 that that IN cord-021424-kocwsyi7 103 11 CCR5 CCR5 NNP cord-021424-kocwsyi7 103 12 is be VBZ cord-021424-kocwsyi7 103 13 a a DT cord-021424-kocwsyi7 103 14 co co NN cord-021424-kocwsyi7 103 15 - - NN cord-021424-kocwsyi7 103 16 receptor receptor NN cord-021424-kocwsyi7 103 17 for for IN cord-021424-kocwsyi7 103 18 HIV HIV NNP cord-021424-kocwsyi7 103 19 on on IN cord-021424-kocwsyi7 103 20 the the DT cord-021424-kocwsyi7 103 21 surface surface NN cord-021424-kocwsyi7 103 22 of of IN cord-021424-kocwsyi7 103 23 T t NN cord-021424-kocwsyi7 103 24 cells cell NNS cord-021424-kocwsyi7 103 25 ( ( -LRB- cord-021424-kocwsyi7 103 26 Dragic Dragic NNP cord-021424-kocwsyi7 103 27 et et NNP cord-021424-kocwsyi7 103 28 al al NNP cord-021424-kocwsyi7 103 29 . . NNP cord-021424-kocwsyi7 103 30 , , , cord-021424-kocwsyi7 103 31 1996 1996 CD cord-021424-kocwsyi7 103 32 ) ) -RRB- cord-021424-kocwsyi7 103 33 . . . cord-021424-kocwsyi7 104 1 A a DT cord-021424-kocwsyi7 104 2 mutation mutation NN cord-021424-kocwsyi7 104 3 in in IN cord-021424-kocwsyi7 104 4 another another DT cord-021424-kocwsyi7 104 5 chemokine chemokine NN cord-021424-kocwsyi7 104 6 receptor receptor NN cord-021424-kocwsyi7 104 7 , , , cord-021424-kocwsyi7 104 8 CCR2 CCR2 NNP cord-021424-kocwsyi7 104 9 , , , cord-021424-kocwsyi7 104 10 has have VBZ cord-021424-kocwsyi7 104 11 also also RB cord-021424-kocwsyi7 104 12 been be VBN cord-021424-kocwsyi7 104 13 shown show VBN cord-021424-kocwsyi7 104 14 to to TO cord-021424-kocwsyi7 104 15 confer confer VB cord-021424-kocwsyi7 104 16 HIV HIV NNP cord-021424-kocwsyi7 104 17 resistance resistance NN cord-021424-kocwsyi7 104 18 in in IN cord-021424-kocwsyi7 104 19 certain certain JJ cord-021424-kocwsyi7 104 20 Caucasian caucasian JJ cord-021424-kocwsyi7 104 21 populations population NNS cord-021424-kocwsyi7 104 22 ( ( -LRB- cord-021424-kocwsyi7 104 23 O'Brien O'Brien NNP cord-021424-kocwsyi7 104 24 and and CC cord-021424-kocwsyi7 104 25 Moore Moore NNP cord-021424-kocwsyi7 104 26 , , , cord-021424-kocwsyi7 104 27 2000 2000 CD cord-021424-kocwsyi7 104 28 ) ) -RRB- cord-021424-kocwsyi7 104 29 . . . cord-021424-kocwsyi7 105 1 Some some DT cord-021424-kocwsyi7 105 2 genes gene NNS cord-021424-kocwsyi7 105 3 have have VBP cord-021424-kocwsyi7 105 4 been be VBN cord-021424-kocwsyi7 105 5 associated associate VBN cord-021424-kocwsyi7 105 6 with with IN cord-021424-kocwsyi7 105 7 susceptibility susceptibility NN cord-021424-kocwsyi7 105 8 or or CC cord-021424-kocwsyi7 105 9 resistance resistance NN cord-021424-kocwsyi7 105 10 to to IN cord-021424-kocwsyi7 105 11 multiple multiple JJ cord-021424-kocwsyi7 105 12 pathogens pathogen NNS cord-021424-kocwsyi7 105 13 . . . cord-021424-kocwsyi7 106 1 For for IN cord-021424-kocwsyi7 106 2 example example NN cord-021424-kocwsyi7 106 3 , , , cord-021424-kocwsyi7 106 4 variation variation NN cord-021424-kocwsyi7 106 5 in in IN cord-021424-kocwsyi7 106 6 the the DT cord-021424-kocwsyi7 106 7 NRAMP1 NRAMP1 NNP cord-021424-kocwsyi7 106 8 / / SYM cord-021424-kocwsyi7 106 9 Slc11a1 Slc11a1 NNP cord-021424-kocwsyi7 106 10 gene gene NN cord-021424-kocwsyi7 106 11 is be VBZ cord-021424-kocwsyi7 106 12 associated associate VBN cord-021424-kocwsyi7 106 13 with with IN cord-021424-kocwsyi7 106 14 susceptibility susceptibility NN cord-021424-kocwsyi7 106 15 to to IN cord-021424-kocwsyi7 106 16 Leishmania Leishmania NNP cord-021424-kocwsyi7 106 17 and and CC cord-021424-kocwsyi7 106 18 to to IN cord-021424-kocwsyi7 106 19 specifi specifi NNP cord-021424-kocwsyi7 106 20 c c NNP cord-021424-kocwsyi7 106 21 intracellular intracellular JJ cord-021424-kocwsyi7 106 22 bacteria bacteria NNS cord-021424-kocwsyi7 106 23 such such JJ cord-021424-kocwsyi7 106 24 as as IN cord-021424-kocwsyi7 106 25 tuberculosis tuberculosis NN cord-021424-kocwsyi7 106 26 ( ( -LRB- cord-021424-kocwsyi7 106 27 Barton Barton NNP cord-021424-kocwsyi7 106 28 et et NNP cord-021424-kocwsyi7 106 29 al al NNP cord-021424-kocwsyi7 106 30 . . NNP cord-021424-kocwsyi7 106 31 , , , cord-021424-kocwsyi7 106 32 1999 1999 CD cord-021424-kocwsyi7 106 33 ; ; : cord-021424-kocwsyi7 106 34 Govoni Govoni NNP cord-021424-kocwsyi7 106 35 et et NNP cord-021424-kocwsyi7 106 36 al al NNP cord-021424-kocwsyi7 106 37 . . NNP cord-021424-kocwsyi7 106 38 , , , cord-021424-kocwsyi7 106 39 1996 1996 CD cord-021424-kocwsyi7 106 40 ; ; : cord-021424-kocwsyi7 106 41 Lipoldova Lipoldova NNP cord-021424-kocwsyi7 106 42 and and CC cord-021424-kocwsyi7 106 43 Demant Demant NNP cord-021424-kocwsyi7 106 44 , , , cord-021424-kocwsyi7 106 45 2006 2006 CD cord-021424-kocwsyi7 106 46 ; ; : cord-021424-kocwsyi7 106 47 Sebastiani Sebastiani NNP cord-021424-kocwsyi7 106 48 et et NNP cord-021424-kocwsyi7 106 49 al al NNP cord-021424-kocwsyi7 106 50 . . NNP cord-021424-kocwsyi7 106 51 , , , cord-021424-kocwsyi7 106 52 1998 1998 CD cord-021424-kocwsyi7 106 53 ) ) -RRB- cord-021424-kocwsyi7 106 54 . . . cord-021424-kocwsyi7 107 1 Mutations mutation NNS cord-021424-kocwsyi7 107 2 in in IN cord-021424-kocwsyi7 107 3 the the DT cord-021424-kocwsyi7 107 4 tumor tumor NN cord-021424-kocwsyi7 107 5 necrosis necrosis NN cord-021424-kocwsyi7 107 6 factor factor NN cord-021424-kocwsyi7 107 7 ( ( -LRB- cord-021424-kocwsyi7 107 8 TNF TNF NNP cord-021424-kocwsyi7 107 9 ) ) -RRB- cord-021424-kocwsyi7 107 10 locus locus NN cord-021424-kocwsyi7 107 11 , , , cord-021424-kocwsyi7 107 12 mainly mainly RB cord-021424-kocwsyi7 107 13 gene gene NN cord-021424-kocwsyi7 107 14 promoter promoter NN cord-021424-kocwsyi7 107 15 mutations mutation NNS cord-021424-kocwsyi7 107 16 , , , cord-021424-kocwsyi7 107 17 have have VBP cord-021424-kocwsyi7 107 18 been be VBN cord-021424-kocwsyi7 107 19 linked link VBN cord-021424-kocwsyi7 107 20 with with IN cord-021424-kocwsyi7 107 21 malaria malaria NN cord-021424-kocwsyi7 107 22 and and CC cord-021424-kocwsyi7 107 23 leprosy leprosy NN cord-021424-kocwsyi7 107 24 susceptibility susceptibility NN cord-021424-kocwsyi7 107 25 ( ( -LRB- cord-021424-kocwsyi7 107 26 Lipoldova Lipoldova NNP cord-021424-kocwsyi7 107 27 and and CC cord-021424-kocwsyi7 107 28 Demant Demant NNP cord-021424-kocwsyi7 107 29 , , , cord-021424-kocwsyi7 107 30 2006 2006 CD cord-021424-kocwsyi7 107 31 ) ) -RRB- cord-021424-kocwsyi7 107 32 . . . cord-021424-kocwsyi7 108 1 Gene gene NN cord-021424-kocwsyi7 108 2 promoter promoter NN cord-021424-kocwsyi7 108 3 or or CC cord-021424-kocwsyi7 108 4 control control NN cord-021424-kocwsyi7 108 5 region region NN cord-021424-kocwsyi7 108 6 mutations mutation NNS cord-021424-kocwsyi7 108 7 have have VBP cord-021424-kocwsyi7 108 8 an an DT cord-021424-kocwsyi7 108 9 impact impact NN cord-021424-kocwsyi7 108 10 on on IN cord-021424-kocwsyi7 108 11 the the DT cord-021424-kocwsyi7 108 12 level level NN cord-021424-kocwsyi7 108 13 of of IN cord-021424-kocwsyi7 108 14 protein protein NN cord-021424-kocwsyi7 108 15 produced produce VBN cord-021424-kocwsyi7 108 16 from from IN cord-021424-kocwsyi7 108 17 the the DT cord-021424-kocwsyi7 108 18 gene gene NN cord-021424-kocwsyi7 108 19 rather rather RB cord-021424-kocwsyi7 108 20 than than IN cord-021424-kocwsyi7 108 21 the the DT cord-021424-kocwsyi7 108 22 function function NN cord-021424-kocwsyi7 108 23 of of IN cord-021424-kocwsyi7 108 24 the the DT cord-021424-kocwsyi7 108 25 protein protein NN cord-021424-kocwsyi7 108 26 . . . cord-021424-kocwsyi7 109 1 This this DT cord-021424-kocwsyi7 109 2 is be VBZ cord-021424-kocwsyi7 109 3 an an DT cord-021424-kocwsyi7 109 4 area area NN cord-021424-kocwsyi7 109 5 of of IN cord-021424-kocwsyi7 109 6 great great JJ cord-021424-kocwsyi7 109 7 interest interest NN cord-021424-kocwsyi7 109 8 but but CC cord-021424-kocwsyi7 109 9 more more JJR cord-021424-kocwsyi7 109 10 diffi diffi JJ cord-021424-kocwsyi7 109 11 cult cult NN cord-021424-kocwsyi7 109 12 to to TO cord-021424-kocwsyi7 109 13 study study VB cord-021424-kocwsyi7 109 14 for for IN cord-021424-kocwsyi7 109 15 several several JJ cord-021424-kocwsyi7 109 16 reasons reason NNS cord-021424-kocwsyi7 109 17 , , , cord-021424-kocwsyi7 109 18 including include VBG cord-021424-kocwsyi7 109 19 the the DT cord-021424-kocwsyi7 109 20 inability inability NN cord-021424-kocwsyi7 109 21 to to TO cord-021424-kocwsyi7 109 22 identify identify VB cord-021424-kocwsyi7 109 23 control control NN cord-021424-kocwsyi7 109 24 regions region NNS cord-021424-kocwsyi7 109 25 simply simply RB cord-021424-kocwsyi7 109 26 from from IN cord-021424-kocwsyi7 109 27 sequence sequence NN cord-021424-kocwsyi7 109 28 information information NN cord-021424-kocwsyi7 109 29 and and CC cord-021424-kocwsyi7 109 30 the the DT cord-021424-kocwsyi7 109 31 complexity complexity NN cord-021424-kocwsyi7 109 32 and and CC cord-021424-kocwsyi7 109 33 fl fl JJ cord-021424-kocwsyi7 109 34 exibility exibility NN cord-021424-kocwsyi7 109 35 of of IN cord-021424-kocwsyi7 109 36 transcriptional transcriptional JJ cord-021424-kocwsyi7 109 37 control control NN cord-021424-kocwsyi7 109 38 . . . cord-021424-kocwsyi7 110 1 A a DT cord-021424-kocwsyi7 110 2 recent recent JJ cord-021424-kocwsyi7 110 3 review review NN cord-021424-kocwsyi7 110 4 detailing detail VBG cord-021424-kocwsyi7 110 5 the the DT cord-021424-kocwsyi7 110 6 genes gene NNS cord-021424-kocwsyi7 110 7 associated associate VBN cord-021424-kocwsyi7 110 8 with with IN cord-021424-kocwsyi7 110 9 Leishmania Leishmania NNP cord-021424-kocwsyi7 110 10 susceptibility susceptibility NN cord-021424-kocwsyi7 110 11 describes describe VBZ cord-021424-kocwsyi7 110 12 a a DT cord-021424-kocwsyi7 110 13 number number NN cord-021424-kocwsyi7 110 14 of of IN cord-021424-kocwsyi7 110 15 genes gene NNS cord-021424-kocwsyi7 110 16 that that WDT cord-021424-kocwsyi7 110 17 can can MD cord-021424-kocwsyi7 110 18 affect affect VB cord-021424-kocwsyi7 110 19 disease disease NN cord-021424-kocwsyi7 110 20 outcome outcome NN cord-021424-kocwsyi7 110 21 including include VBG cord-021424-kocwsyi7 110 22 the the DT cord-021424-kocwsyi7 110 23 interferon interferon NN cord-021424-kocwsyi7 110 24 - - HYPH cord-021424-kocwsyi7 110 25 gamma gamma NN cord-021424-kocwsyi7 110 26 receptor receptor NN cord-021424-kocwsyi7 110 27 type type NN cord-021424-kocwsyi7 110 28 1 1 CD cord-021424-kocwsyi7 110 29 ( ( -LRB- cord-021424-kocwsyi7 110 30 IFNGR1 IFNGR1 NNP cord-021424-kocwsyi7 110 31 ) ) -RRB- cord-021424-kocwsyi7 110 32 , , , cord-021424-kocwsyi7 110 33 the the DT cord-021424-kocwsyi7 110 34 interleukin-4 interleukin-4 NNP cord-021424-kocwsyi7 110 35 ( ( -LRB- cord-021424-kocwsyi7 110 36 IL-4 IL-4 NNP cord-021424-kocwsyi7 110 37 ) ) -RRB- cord-021424-kocwsyi7 110 38 gene gene NN cord-021424-kocwsyi7 110 39 and and CC cord-021424-kocwsyi7 110 40 the the DT cord-021424-kocwsyi7 110 41 NRAMP-1 NRAMP-1 NNP cord-021424-kocwsyi7 110 42 / / SYM cord-021424-kocwsyi7 110 43 Slc11a1 slc11a1 NN cord-021424-kocwsyi7 110 44 gene gene NN cord-021424-kocwsyi7 110 45 ( ( -LRB- cord-021424-kocwsyi7 110 46 Lipoldova Lipoldova NNP cord-021424-kocwsyi7 110 47 and and CC cord-021424-kocwsyi7 110 48 Demant Demant NNP cord-021424-kocwsyi7 110 49 , , , cord-021424-kocwsyi7 110 50 2006 2006 CD cord-021424-kocwsyi7 110 51 ) ) -RRB- cord-021424-kocwsyi7 110 52 . . . cord-021424-kocwsyi7 111 1 These these DT cord-021424-kocwsyi7 111 2 genes gene NNS cord-021424-kocwsyi7 111 3 and and CC cord-021424-kocwsyi7 111 4 others other NNS cord-021424-kocwsyi7 111 5 such such JJ cord-021424-kocwsyi7 111 6 as as IN cord-021424-kocwsyi7 111 7 interleukin-12 interleukin-12 NNP cord-021424-kocwsyi7 111 8 ( ( -LRB- cord-021424-kocwsyi7 111 9 IL-12 IL-12 NNP cord-021424-kocwsyi7 111 10 ) ) -RRB- cord-021424-kocwsyi7 111 11 and and CC cord-021424-kocwsyi7 111 12 its -PRON- PRP$ cord-021424-kocwsyi7 111 13 receptor receptor NN cord-021424-kocwsyi7 111 14 are be VBP cord-021424-kocwsyi7 111 15 also also RB cord-021424-kocwsyi7 111 16 linked link VBN cord-021424-kocwsyi7 111 17 with with IN cord-021424-kocwsyi7 111 18 Salmonella Salmonella NNP cord-021424-kocwsyi7 111 19 and and CC cord-021424-kocwsyi7 111 20 certain certain JJ cord-021424-kocwsyi7 111 21 mycobacterial mycobacterial JJ cord-021424-kocwsyi7 111 22 infections infection NNS cord-021424-kocwsyi7 111 23 ( ( -LRB- cord-021424-kocwsyi7 111 24 Lipoldova Lipoldova NNP cord-021424-kocwsyi7 111 25 and and CC cord-021424-kocwsyi7 111 26 Demant Demant NNP cord-021424-kocwsyi7 111 27 , , , cord-021424-kocwsyi7 111 28 2006 2006 CD cord-021424-kocwsyi7 111 29 ) ) -RRB- cord-021424-kocwsyi7 111 30 . . . cord-021424-kocwsyi7 112 1 Thus thus RB cord-021424-kocwsyi7 112 2 , , , cord-021424-kocwsyi7 112 3 it -PRON- PRP cord-021424-kocwsyi7 112 4 is be VBZ cord-021424-kocwsyi7 112 5 likely likely JJ cord-021424-kocwsyi7 112 6 that that DT cord-021424-kocwsyi7 112 7 variation variation NN cord-021424-kocwsyi7 112 8 in in IN cord-021424-kocwsyi7 112 9 many many JJ cord-021424-kocwsyi7 112 10 genes gene NNS cord-021424-kocwsyi7 112 11 can can MD cord-021424-kocwsyi7 112 12 contribute contribute VB cord-021424-kocwsyi7 112 13 to to IN cord-021424-kocwsyi7 112 14 disturbing disturb VBG cord-021424-kocwsyi7 112 15 the the DT cord-021424-kocwsyi7 112 16 fi fi NNP cord-021424-kocwsyi7 112 17 nely nely RB cord-021424-kocwsyi7 112 18 balanced balanced JJ cord-021424-kocwsyi7 112 19 tuning tuning NN cord-021424-kocwsyi7 112 20 of of IN cord-021424-kocwsyi7 112 21 the the DT cord-021424-kocwsyi7 112 22 immune immune JJ cord-021424-kocwsyi7 112 23 system system NN cord-021424-kocwsyi7 112 24 and and CC cord-021424-kocwsyi7 112 25 lead lead VB cord-021424-kocwsyi7 112 26 to to IN cord-021424-kocwsyi7 112 27 an an DT cord-021424-kocwsyi7 112 28 altered altered JJ cord-021424-kocwsyi7 112 29 response response NN cord-021424-kocwsyi7 112 30 to to IN cord-021424-kocwsyi7 112 31 a a DT cord-021424-kocwsyi7 112 32 pathogen pathogen NN cord-021424-kocwsyi7 112 33 . . . cord-021424-kocwsyi7 113 1 It -PRON- PRP cord-021424-kocwsyi7 113 2 is be VBZ cord-021424-kocwsyi7 113 3 clear clear JJ cord-021424-kocwsyi7 113 4 from from IN cord-021424-kocwsyi7 113 5 such such JJ cord-021424-kocwsyi7 113 6 studies study NNS cord-021424-kocwsyi7 113 7 that that WDT cord-021424-kocwsyi7 113 8 the the DT cord-021424-kocwsyi7 113 9 same same JJ cord-021424-kocwsyi7 113 10 genes gene NNS cord-021424-kocwsyi7 113 11 may may MD cord-021424-kocwsyi7 113 12 be be VB cord-021424-kocwsyi7 113 13 involved involve VBN cord-021424-kocwsyi7 113 14 in in IN cord-021424-kocwsyi7 113 15 susceptibility susceptibility NN cord-021424-kocwsyi7 113 16 to to IN cord-021424-kocwsyi7 113 17 an an DT cord-021424-kocwsyi7 113 18 array array NN cord-021424-kocwsyi7 113 19 of of IN cord-021424-kocwsyi7 113 20 pathogens pathogen NNS cord-021424-kocwsyi7 113 21 indicating indicate VBG cord-021424-kocwsyi7 113 22 a a DT cord-021424-kocwsyi7 113 23 core core JJ cord-021424-kocwsyi7 113 24 immune immune JJ cord-021424-kocwsyi7 113 25 response response NN cord-021424-kocwsyi7 113 26 critical critical JJ cord-021424-kocwsyi7 113 27 for for IN cord-021424-kocwsyi7 113 28 any any DT cord-021424-kocwsyi7 113 29 pathogen pathogen NN cord-021424-kocwsyi7 113 30 . . . cord-021424-kocwsyi7 114 1 The the DT cord-021424-kocwsyi7 114 2 identifi identifi NNP cord-021424-kocwsyi7 114 3 cation cation NN cord-021424-kocwsyi7 114 4 of of IN cord-021424-kocwsyi7 114 5 susceptibility susceptibility NN cord-021424-kocwsyi7 114 6 loci locus NNS cord-021424-kocwsyi7 114 7 for for IN cord-021424-kocwsyi7 114 8 infection infection NN cord-021424-kocwsyi7 114 9 with with IN cord-021424-kocwsyi7 114 10 various various JJ cord-021424-kocwsyi7 114 11 pathogens pathogen NNS cord-021424-kocwsyi7 114 12 will will MD cord-021424-kocwsyi7 114 13 aid aid VB cord-021424-kocwsyi7 114 14 in in IN cord-021424-kocwsyi7 114 15 developing develop VBG cord-021424-kocwsyi7 114 16 new new JJ cord-021424-kocwsyi7 114 17 diagnostic diagnostic JJ cord-021424-kocwsyi7 114 18 screens screen NNS cord-021424-kocwsyi7 114 19 based base VBN cord-021424-kocwsyi7 114 20 on on IN cord-021424-kocwsyi7 114 21 the the DT cord-021424-kocwsyi7 114 22 detection detection NN cord-021424-kocwsyi7 114 23 of of IN cord-021424-kocwsyi7 114 24 genetic genetic JJ cord-021424-kocwsyi7 114 25 variants variant NNS cord-021424-kocwsyi7 114 26 in in IN cord-021424-kocwsyi7 114 27 these these DT cord-021424-kocwsyi7 114 28 loci locus NNS cord-021424-kocwsyi7 114 29 . . . cord-021424-kocwsyi7 115 1 It -PRON- PRP cord-021424-kocwsyi7 115 2 could could MD cord-021424-kocwsyi7 115 3 be be VB cord-021424-kocwsyi7 115 4 envisaged envisage VBN cord-021424-kocwsyi7 115 5 that that IN cord-021424-kocwsyi7 115 6 a a DT cord-021424-kocwsyi7 115 7 person person NN cord-021424-kocwsyi7 115 8 's 's POS cord-021424-kocwsyi7 115 9 susceptibility susceptibility NN cord-021424-kocwsyi7 115 10 or or CC cord-021424-kocwsyi7 115 11 resistance resistance NN cord-021424-kocwsyi7 115 12 to to IN cord-021424-kocwsyi7 115 13 a a DT cord-021424-kocwsyi7 115 14 pathogen pathogen NN cord-021424-kocwsyi7 115 15 could could MD cord-021424-kocwsyi7 115 16 be be VB cord-021424-kocwsyi7 115 17 defi defi NNP cord-021424-kocwsyi7 115 18 ned ned NNP cord-021424-kocwsyi7 115 19 by by IN cord-021424-kocwsyi7 115 20 a a DT cord-021424-kocwsyi7 115 21 simple simple JJ cord-021424-kocwsyi7 115 22 genotyping genotyping NN cord-021424-kocwsyi7 115 23 screen screen NN cord-021424-kocwsyi7 115 24 either either CC cord-021424-kocwsyi7 115 25 prior prior RB cord-021424-kocwsyi7 115 26 to to IN cord-021424-kocwsyi7 115 27 exposure exposure NN cord-021424-kocwsyi7 115 28 to to IN cord-021424-kocwsyi7 115 29 any any DT cord-021424-kocwsyi7 115 30 pathogen pathogen NN cord-021424-kocwsyi7 115 31 or or CC cord-021424-kocwsyi7 115 32 upon upon IN cord-021424-kocwsyi7 115 33 presentation presentation NN cord-021424-kocwsyi7 115 34 with with IN cord-021424-kocwsyi7 115 35 an an DT cord-021424-kocwsyi7 115 36 infection infection NN cord-021424-kocwsyi7 115 37 . . . cord-021424-kocwsyi7 116 1 It -PRON- PRP cord-021424-kocwsyi7 116 2 may may MD cord-021424-kocwsyi7 116 3 also also RB cord-021424-kocwsyi7 116 4 be be VB cord-021424-kocwsyi7 116 5 possible possible JJ cord-021424-kocwsyi7 116 6 to to TO cord-021424-kocwsyi7 116 7 determine determine VB cord-021424-kocwsyi7 116 8 the the DT cord-021424-kocwsyi7 116 9 likely likely JJ cord-021424-kocwsyi7 116 10 outcome outcome NN cord-021424-kocwsyi7 116 11 of of IN cord-021424-kocwsyi7 116 12 the the DT cord-021424-kocwsyi7 116 13 infection infection NN cord-021424-kocwsyi7 116 14 through through IN cord-021424-kocwsyi7 116 15 a a DT cord-021424-kocwsyi7 116 16 genotyping genotyping NN cord-021424-kocwsyi7 116 17 screen screen NN cord-021424-kocwsyi7 116 18 . . . cord-021424-kocwsyi7 117 1 The the DT cord-021424-kocwsyi7 117 2 defi defi NNP cord-021424-kocwsyi7 117 3 nition nition NN cord-021424-kocwsyi7 117 4 of of IN cord-021424-kocwsyi7 117 5 susceptibility susceptibility NN cord-021424-kocwsyi7 117 6 loci locus NNS cord-021424-kocwsyi7 117 7 will will MD cord-021424-kocwsyi7 117 8 also also RB cord-021424-kocwsyi7 117 9 contribute contribute VB cord-021424-kocwsyi7 117 10 to to IN cord-021424-kocwsyi7 117 11 our -PRON- PRP$ cord-021424-kocwsyi7 117 12 ability ability NN cord-021424-kocwsyi7 117 13 to to TO cord-021424-kocwsyi7 117 14 develop develop VB cord-021424-kocwsyi7 117 15 new new JJ cord-021424-kocwsyi7 117 16 vaccines vaccine NNS cord-021424-kocwsyi7 117 17 and and CC cord-021424-kocwsyi7 117 18 therapeutics therapeutic NNS cord-021424-kocwsyi7 117 19 . . . cord-021424-kocwsyi7 118 1 The the DT cord-021424-kocwsyi7 118 2 use use NN cord-021424-kocwsyi7 118 3 of of IN cord-021424-kocwsyi7 118 4 microarray microarray NN cord-021424-kocwsyi7 118 5 technology technology NN cord-021424-kocwsyi7 118 6 to to TO cord-021424-kocwsyi7 118 7 generate generate VB cord-021424-kocwsyi7 118 8 expression expression NN cord-021424-kocwsyi7 118 9 profi profi NNP cord-021424-kocwsyi7 118 10 ling ling NNP cord-021424-kocwsyi7 118 11 data data NNP cord-021424-kocwsyi7 118 12 is be VBZ cord-021424-kocwsyi7 118 13 becoming become VBG cord-021424-kocwsyi7 118 14 common common JJ cord-021424-kocwsyi7 118 15 place place NN cord-021424-kocwsyi7 118 16 in in IN cord-021424-kocwsyi7 118 17 biomedical biomedical JJ cord-021424-kocwsyi7 118 18 research research NN cord-021424-kocwsyi7 118 19 ( ( -LRB- cord-021424-kocwsyi7 118 20 reviewed review VBN cord-021424-kocwsyi7 118 21 in in IN cord-021424-kocwsyi7 118 22 [ [ -LRB- cord-021424-kocwsyi7 118 23 Quackenbush Quackenbush NNP cord-021424-kocwsyi7 118 24 , , , cord-021424-kocwsyi7 118 25 2002 2002 CD cord-021424-kocwsyi7 118 26 ; ; : cord-021424-kocwsyi7 118 27 Sherlock Sherlock NNP cord-021424-kocwsyi7 118 28 , , , cord-021424-kocwsyi7 118 29 2000 2000 CD cord-021424-kocwsyi7 118 30 ] ] -RRB- cord-021424-kocwsyi7 118 31 ) ) -RRB- cord-021424-kocwsyi7 118 32 . . . cord-021424-kocwsyi7 119 1 This this DT cord-021424-kocwsyi7 119 2 technology technology NN cord-021424-kocwsyi7 119 3 allows allow VBZ cord-021424-kocwsyi7 119 4 the the DT cord-021424-kocwsyi7 119 5 documentation documentation NN cord-021424-kocwsyi7 119 6 of of IN cord-021424-kocwsyi7 119 7 mRNA mRNA NNP cord-021424-kocwsyi7 119 8 levels level NNS cord-021424-kocwsyi7 119 9 for for IN cord-021424-kocwsyi7 119 10 thousands thousand NNS cord-021424-kocwsyi7 119 11 of of IN cord-021424-kocwsyi7 119 12 genes gene NNS cord-021424-kocwsyi7 119 13 from from IN cord-021424-kocwsyi7 119 14 total total JJ cord-021424-kocwsyi7 119 15 RNA RNA NNP cord-021424-kocwsyi7 119 16 prepared prepare VBN cord-021424-kocwsyi7 119 17 from from IN cord-021424-kocwsyi7 119 18 cells cell NNS cord-021424-kocwsyi7 119 19 or or CC cord-021424-kocwsyi7 119 20 tissue tissue NN cord-021424-kocwsyi7 119 21 samples sample NNS cord-021424-kocwsyi7 119 22 . . . cord-021424-kocwsyi7 120 1 The the DT cord-021424-kocwsyi7 120 2 data datum NNS cord-021424-kocwsyi7 120 3 obtained obtain VBN cord-021424-kocwsyi7 120 4 can can MD cord-021424-kocwsyi7 120 5 be be VB cord-021424-kocwsyi7 120 6 compared compare VBN cord-021424-kocwsyi7 120 7 from from IN cord-021424-kocwsyi7 120 8 sample sample NN cord-021424-kocwsyi7 120 9 to to TO cord-021424-kocwsyi7 120 10 sample sample VB cord-021424-kocwsyi7 120 11 allowing allow VBG cord-021424-kocwsyi7 120 12 the the DT cord-021424-kocwsyi7 120 13 changes change NNS cord-021424-kocwsyi7 120 14 between between IN cord-021424-kocwsyi7 120 15 samples sample NNS cord-021424-kocwsyi7 120 16 to to TO cord-021424-kocwsyi7 120 17 be be VB cord-021424-kocwsyi7 120 18 documented document VBN cord-021424-kocwsyi7 120 19 and and CC cord-021424-kocwsyi7 120 20 quantifi quantifi NNP cord-021424-kocwsyi7 120 21 ed ed NNP cord-021424-kocwsyi7 120 22 . . . cord-021424-kocwsyi7 121 1 The the DT cord-021424-kocwsyi7 121 2 " " `` cord-021424-kocwsyi7 121 3 expression expression NN cord-021424-kocwsyi7 121 4 profi profi NNP cord-021424-kocwsyi7 121 5 le le FW cord-021424-kocwsyi7 121 6 " " '' cord-021424-kocwsyi7 121 7 for for IN cord-021424-kocwsyi7 121 8 any any DT cord-021424-kocwsyi7 121 9 cell cell NN cord-021424-kocwsyi7 121 10 or or CC cord-021424-kocwsyi7 121 11 tissue tissue NN cord-021424-kocwsyi7 121 12 is be VBZ cord-021424-kocwsyi7 121 13 simply simply RB cord-021424-kocwsyi7 121 14 the the DT cord-021424-kocwsyi7 121 15 list list NN cord-021424-kocwsyi7 121 16 of of IN cord-021424-kocwsyi7 121 17 genes gene NNS cord-021424-kocwsyi7 121 18 whose whose WP$ cord-021424-kocwsyi7 121 19 expression expression NN cord-021424-kocwsyi7 121 20 can can MD cord-021424-kocwsyi7 121 21 be be VB cord-021424-kocwsyi7 121 22 detected detect VBN cord-021424-kocwsyi7 121 23 using use VBG cord-021424-kocwsyi7 121 24 microarrays microarray NNS cord-021424-kocwsyi7 121 25 . . . cord-021424-kocwsyi7 122 1 The the DT cord-021424-kocwsyi7 122 2 differences difference NNS cord-021424-kocwsyi7 122 3 in in IN cord-021424-kocwsyi7 122 4 the the DT cord-021424-kocwsyi7 122 5 expression expression NN cord-021424-kocwsyi7 122 6 profi profi NNP cord-021424-kocwsyi7 122 7 le le NNP cord-021424-kocwsyi7 122 8 from from IN cord-021424-kocwsyi7 122 9 one one CD cord-021424-kocwsyi7 122 10 cell cell NN cord-021424-kocwsyi7 122 11 or or CC cord-021424-kocwsyi7 122 12 tissue tissue NN cord-021424-kocwsyi7 122 13 to to IN cord-021424-kocwsyi7 122 14 the the DT cord-021424-kocwsyi7 122 15 next next JJ cord-021424-kocwsyi7 122 16 or or CC cord-021424-kocwsyi7 122 17 in in IN cord-021424-kocwsyi7 122 18 cells cell NNS cord-021424-kocwsyi7 122 19 treated treat VBN cord-021424-kocwsyi7 122 20 in in IN cord-021424-kocwsyi7 122 21 a a DT cord-021424-kocwsyi7 122 22 specifi specifi NN cord-021424-kocwsyi7 122 23 c c NN cord-021424-kocwsyi7 122 24 manner manner NN cord-021424-kocwsyi7 122 25 is be VBZ cord-021424-kocwsyi7 122 26 a a DT cord-021424-kocwsyi7 122 27 surrogate surrogate JJ cord-021424-kocwsyi7 122 28 measure measure NN cord-021424-kocwsyi7 122 29 of of IN cord-021424-kocwsyi7 122 30 the the DT cord-021424-kocwsyi7 122 31 cell cell NN cord-021424-kocwsyi7 122 32 / / SYM cord-021424-kocwsyi7 122 33 tissue tissue NN cord-021424-kocwsyi7 122 34 phenotype phenotype NN cord-021424-kocwsyi7 122 35 and and CC cord-021424-kocwsyi7 122 36 shows show VBZ cord-021424-kocwsyi7 122 37 how how WRB cord-021424-kocwsyi7 122 38 that that DT cord-021424-kocwsyi7 122 39 phenotype phenotype NN cord-021424-kocwsyi7 122 40 responds respond VBZ cord-021424-kocwsyi7 122 41 to to IN cord-021424-kocwsyi7 122 42 its -PRON- PRP$ cord-021424-kocwsyi7 122 43 environment environment NN cord-021424-kocwsyi7 122 44 . . . cord-021424-kocwsyi7 123 1 Expression expression NN cord-021424-kocwsyi7 123 2 profi profi NNP cord-021424-kocwsyi7 123 3 ling ling NNP cord-021424-kocwsyi7 123 4 is be VBZ cord-021424-kocwsyi7 123 5 most most RBS cord-021424-kocwsyi7 123 6 useful useful JJ cord-021424-kocwsyi7 123 7 when when WRB cord-021424-kocwsyi7 123 8 large large JJ cord-021424-kocwsyi7 123 9 datasets dataset NNS cord-021424-kocwsyi7 123 10 become become VBP cord-021424-kocwsyi7 123 11 available available JJ cord-021424-kocwsyi7 123 12 and and CC cord-021424-kocwsyi7 123 13 when when WRB cord-021424-kocwsyi7 123 14 the the DT cord-021424-kocwsyi7 123 15 data data NN cord-021424-kocwsyi7 123 16 is be VBZ cord-021424-kocwsyi7 123 17 combined combine VBN cord-021424-kocwsyi7 123 18 with with IN cord-021424-kocwsyi7 123 19 other other JJ cord-021424-kocwsyi7 123 20 data datum NNS cord-021424-kocwsyi7 123 21 types type NNS cord-021424-kocwsyi7 123 22 and and CC cord-021424-kocwsyi7 123 23 detailed detailed JJ cord-021424-kocwsyi7 123 24 bioinformatics bioinformatic NNS cord-021424-kocwsyi7 123 25 studies study NNS cord-021424-kocwsyi7 123 26 . . . cord-021424-kocwsyi7 124 1 For for IN cord-021424-kocwsyi7 124 2 example example NN cord-021424-kocwsyi7 124 3 , , , cord-021424-kocwsyi7 124 4 using use VBG cord-021424-kocwsyi7 124 5 functional functional JJ cord-021424-kocwsyi7 124 6 clustering clustering NN cord-021424-kocwsyi7 124 7 of of IN cord-021424-kocwsyi7 124 8 expression expression NN cord-021424-kocwsyi7 124 9 profi profi NNP cord-021424-kocwsyi7 124 10 ling ling NNP cord-021424-kocwsyi7 124 11 data datum NNS cord-021424-kocwsyi7 124 12 can can MD cord-021424-kocwsyi7 124 13 help help VB cord-021424-kocwsyi7 124 14 identify identify VB cord-021424-kocwsyi7 124 15 pathways pathway NNS cord-021424-kocwsyi7 124 16 that that WDT cord-021424-kocwsyi7 124 17 are be VBP cord-021424-kocwsyi7 124 18 important important JJ cord-021424-kocwsyi7 124 19 for for IN cord-021424-kocwsyi7 124 20 a a DT cord-021424-kocwsyi7 124 21 particular particular JJ cord-021424-kocwsyi7 124 22 process process NN cord-021424-kocwsyi7 124 23 and and CC cord-021424-kocwsyi7 124 24 co co JJ cord-021424-kocwsyi7 124 25 - - JJ cord-021424-kocwsyi7 124 26 expression expression JJ cord-021424-kocwsyi7 124 27 clustering clustering NN cord-021424-kocwsyi7 124 28 combined combine VBN cord-021424-kocwsyi7 124 29 with with IN cord-021424-kocwsyi7 124 30 other other JJ cord-021424-kocwsyi7 124 31 technologies technology NNS cord-021424-kocwsyi7 124 32 can can MD cord-021424-kocwsyi7 124 33 help help VB cord-021424-kocwsyi7 124 34 defi defi NNP cord-021424-kocwsyi7 124 35 ne ne NNP cord-021424-kocwsyi7 124 36 regulatory regulatory JJ cord-021424-kocwsyi7 124 37 networks network NNS cord-021424-kocwsyi7 124 38 within within IN cord-021424-kocwsyi7 124 39 the the DT cord-021424-kocwsyi7 124 40 cell cell NN cord-021424-kocwsyi7 124 41 . . . cord-021424-kocwsyi7 125 1 Over over IN cord-021424-kocwsyi7 125 2 the the DT cord-021424-kocwsyi7 125 3 last last JJ cord-021424-kocwsyi7 125 4 5 5 CD cord-021424-kocwsyi7 125 5 - - SYM cord-021424-kocwsyi7 125 6 6 6 CD cord-021424-kocwsyi7 125 7 years year NNS cord-021424-kocwsyi7 125 8 , , , cord-021424-kocwsyi7 125 9 this this DT cord-021424-kocwsyi7 125 10 technology technology NN cord-021424-kocwsyi7 125 11 has have VBZ cord-021424-kocwsyi7 125 12 been be VBN cord-021424-kocwsyi7 125 13 applied apply VBN cord-021424-kocwsyi7 125 14 to to IN cord-021424-kocwsyi7 125 15 identifying identify VBG cord-021424-kocwsyi7 125 16 the the DT cord-021424-kocwsyi7 125 17 changes change NNS cord-021424-kocwsyi7 125 18 in in IN cord-021424-kocwsyi7 125 19 gene gene NN cord-021424-kocwsyi7 125 20 expression expression NN cord-021424-kocwsyi7 125 21 that that WDT cord-021424-kocwsyi7 125 22 occur occur VBP cord-021424-kocwsyi7 125 23 in in IN cord-021424-kocwsyi7 125 24 response response NN cord-021424-kocwsyi7 125 25 to to IN cord-021424-kocwsyi7 125 26 infection infection NN cord-021424-kocwsyi7 125 27 by by IN cord-021424-kocwsyi7 125 28 various various JJ cord-021424-kocwsyi7 125 29 pathogens pathogen NNS cord-021424-kocwsyi7 126 1 ( ( -LRB- cord-021424-kocwsyi7 126 2 Aderem Aderem NNP cord-021424-kocwsyi7 126 3 and and CC cord-021424-kocwsyi7 126 4 Smith Smith NNP cord-021424-kocwsyi7 126 5 , , , cord-021424-kocwsyi7 126 6 2004 2004 CD cord-021424-kocwsyi7 126 7 ; ; : cord-021424-kocwsyi7 126 8 Boyce Boyce NNP cord-021424-kocwsyi7 126 9 et et NNP cord-021424-kocwsyi7 126 10 al al NNP cord-021424-kocwsyi7 126 11 . . NNP cord-021424-kocwsyi7 126 12 , , , cord-021424-kocwsyi7 126 13 2004 2004 CD cord-021424-kocwsyi7 126 14 ; ; : cord-021424-kocwsyi7 126 15 Bryant Bryant NNP cord-021424-kocwsyi7 126 16 et et NNP cord-021424-kocwsyi7 126 17 al al NNP cord-021424-kocwsyi7 126 18 . . NNP cord-021424-kocwsyi7 126 19 , , , cord-021424-kocwsyi7 126 20 2004 2004 CD cord-021424-kocwsyi7 126 21 ; ; : cord-021424-kocwsyi7 126 22 Feezor Feezor NNP cord-021424-kocwsyi7 126 23 et et NNP cord-021424-kocwsyi7 126 24 al al NNP cord-021424-kocwsyi7 126 25 . . NNP cord-021424-kocwsyi7 126 26 , , , cord-021424-kocwsyi7 126 27 2005 2005 CD cord-021424-kocwsyi7 126 28 ; ; : cord-021424-kocwsyi7 127 1 Foti Foti NNP cord-021424-kocwsyi7 127 2 et et NNP cord-021424-kocwsyi7 127 3 al al NNP cord-021424-kocwsyi7 127 4 . . NNP cord-021424-kocwsyi7 127 5 , , , cord-021424-kocwsyi7 127 6 2006 2006 CD cord-021424-kocwsyi7 127 7 ; ; : cord-021424-kocwsyi7 127 8 Jenner Jenner NNP cord-021424-kocwsyi7 127 9 and and CC cord-021424-kocwsyi7 127 10 Young Young NNP cord-021424-kocwsyi7 127 11 , , , cord-021424-kocwsyi7 127 12 2005 2005 CD cord-021424-kocwsyi7 127 13 ; ; : cord-021424-kocwsyi7 127 14 Korth Korth NNP cord-021424-kocwsyi7 127 15 and and CC cord-021424-kocwsyi7 127 16 Katze Katze NNP cord-021424-kocwsyi7 127 17 , , , cord-021424-kocwsyi7 127 18 2002 2002 CD cord-021424-kocwsyi7 127 19 ; ; : cord-021424-kocwsyi7 127 20 Korth Korth NNP cord-021424-kocwsyi7 127 21 et et NNP cord-021424-kocwsyi7 127 22 al al NNP cord-021424-kocwsyi7 127 23 . . NNP cord-021424-kocwsyi7 127 24 , , , cord-021424-kocwsyi7 127 25 2005 2005 CD cord-021424-kocwsyi7 127 26 ; ; : cord-021424-kocwsyi7 127 27 Ricciardi Ricciardi NNPS cord-021424-kocwsyi7 127 28 - - HYPH cord-021424-kocwsyi7 127 29 Castagnoli Castagnoli NNP cord-021424-kocwsyi7 127 30 and and CC cord-021424-kocwsyi7 127 31 Granucci Granucci NNP cord-021424-kocwsyi7 127 32 , , , cord-021424-kocwsyi7 127 33 2002 2002 CD cord-021424-kocwsyi7 127 34 ) ) -RRB- cord-021424-kocwsyi7 127 35 . . . cord-021424-kocwsyi7 128 1 To to IN cord-021424-kocwsyi7 128 2 date date NN cord-021424-kocwsyi7 128 3 there there EX cord-021424-kocwsyi7 128 4 are be VBP cord-021424-kocwsyi7 128 5 more more JJR cord-021424-kocwsyi7 128 6 than than IN cord-021424-kocwsyi7 128 7 150 150 CD cord-021424-kocwsyi7 128 8 papers paper NNS cord-021424-kocwsyi7 128 9 in in IN cord-021424-kocwsyi7 128 10 the the DT cord-021424-kocwsyi7 128 11 literature literature NN cord-021424-kocwsyi7 128 12 that that WDT cord-021424-kocwsyi7 128 13 describe describe VBP cord-021424-kocwsyi7 128 14 gene gene NN cord-021424-kocwsyi7 128 15 expression expression NN cord-021424-kocwsyi7 128 16 changes change NNS cord-021424-kocwsyi7 128 17 that that WDT cord-021424-kocwsyi7 128 18 occur occur VBP cord-021424-kocwsyi7 128 19 in in IN cord-021424-kocwsyi7 128 20 response response NN cord-021424-kocwsyi7 128 21 to to IN cord-021424-kocwsyi7 128 22 infection infection NN cord-021424-kocwsyi7 128 23 with with IN cord-021424-kocwsyi7 128 24 a a DT cord-021424-kocwsyi7 128 25 plethora plethora NN cord-021424-kocwsyi7 128 26 of of IN cord-021424-kocwsyi7 128 27 pathogens pathogen NNS cord-021424-kocwsyi7 128 28 and and CC cord-021424-kocwsyi7 128 29 in in IN cord-021424-kocwsyi7 128 30 many many JJ cord-021424-kocwsyi7 128 31 cell cell NN cord-021424-kocwsyi7 128 32 types type NNS cord-021424-kocwsyi7 128 33 ( ( -LRB- cord-021424-kocwsyi7 128 34 reviewed review VBN cord-021424-kocwsyi7 128 35 in in IN cord-021424-kocwsyi7 128 36 [ [ -LRB- cord-021424-kocwsyi7 128 37 Jenner Jenner NNP cord-021424-kocwsyi7 128 38 and and CC cord-021424-kocwsyi7 128 39 Young Young NNP cord-021424-kocwsyi7 128 40 , , , cord-021424-kocwsyi7 128 41 2005 2005 CD cord-021424-kocwsyi7 128 42 ] ] -RRB- cord-021424-kocwsyi7 128 43 ) ) -RRB- cord-021424-kocwsyi7 128 44 . . . cord-021424-kocwsyi7 129 1 Many many JJ cord-021424-kocwsyi7 129 2 of of IN cord-021424-kocwsyi7 129 3 these these DT cord-021424-kocwsyi7 129 4 are be VBP cord-021424-kocwsyi7 129 5 in in IN cord-021424-kocwsyi7 129 6 vitro vitro FW cord-021424-kocwsyi7 129 7 studies study NNS cord-021424-kocwsyi7 129 8 , , , cord-021424-kocwsyi7 129 9 taking take VBG cord-021424-kocwsyi7 129 10 specifi specifi NNP cord-021424-kocwsyi7 129 11 c c NN cord-021424-kocwsyi7 129 12 cell cell NN cord-021424-kocwsyi7 129 13 types type NNS cord-021424-kocwsyi7 129 14 and and CC cord-021424-kocwsyi7 129 15 infecting infect VBG cord-021424-kocwsyi7 129 16 them -PRON- PRP cord-021424-kocwsyi7 129 17 with with IN cord-021424-kocwsyi7 129 18 specifi specifi NNP cord-021424-kocwsyi7 129 19 c c NN cord-021424-kocwsyi7 129 20 agents agent NNS cord-021424-kocwsyi7 129 21 including include VBG cord-021424-kocwsyi7 129 22 bacteria bacteria NNS cord-021424-kocwsyi7 129 23 , , , cord-021424-kocwsyi7 129 24 viruses virus NNS cord-021424-kocwsyi7 129 25 , , , cord-021424-kocwsyi7 129 26 parasites parasite NNS cord-021424-kocwsyi7 129 27 and and CC cord-021424-kocwsyi7 129 28 yeasts yeast NNS cord-021424-kocwsyi7 129 29 . . . cord-021424-kocwsyi7 130 1 In in IN cord-021424-kocwsyi7 130 2 addition addition NN cord-021424-kocwsyi7 130 3 , , , cord-021424-kocwsyi7 130 4 cellular cellular JJ cord-021424-kocwsyi7 130 5 responses response NNS cord-021424-kocwsyi7 130 6 to to IN cord-021424-kocwsyi7 130 7 bacterial bacterial JJ cord-021424-kocwsyi7 130 8 components component NNS cord-021424-kocwsyi7 130 9 have have VBP cord-021424-kocwsyi7 130 10 also also RB cord-021424-kocwsyi7 130 11 been be VBN cord-021424-kocwsyi7 130 12 documented document VBN cord-021424-kocwsyi7 130 13 , , , cord-021424-kocwsyi7 130 14 helping help VBG cord-021424-kocwsyi7 130 15 to to TO cord-021424-kocwsyi7 130 16 identify identify VB cord-021424-kocwsyi7 130 17 pathogen pathogen NN cord-021424-kocwsyi7 130 18 - - HYPH cord-021424-kocwsyi7 130 19 specifi specifi VBN cord-021424-kocwsyi7 130 20 c c NN cord-021424-kocwsyi7 130 21 responses response NNS cord-021424-kocwsyi7 130 22 as as RB cord-021424-kocwsyi7 130 23 well well RB cord-021424-kocwsyi7 130 24 as as IN cord-021424-kocwsyi7 130 25 determining determine VBG cord-021424-kocwsyi7 130 26 the the DT cord-021424-kocwsyi7 130 27 pathogenic pathogenic JJ cord-021424-kocwsyi7 130 28 component component NN cord-021424-kocwsyi7 130 29 responsible responsible JJ cord-021424-kocwsyi7 130 30 for for IN cord-021424-kocwsyi7 130 31 the the DT cord-021424-kocwsyi7 130 32 major major JJ cord-021424-kocwsyi7 130 33 gene gene NN cord-021424-kocwsyi7 130 34 expression expression NN cord-021424-kocwsyi7 130 35 effects effect NNS cord-021424-kocwsyi7 130 36 . . . cord-021424-kocwsyi7 131 1 Virulent virulent JJ cord-021424-kocwsyi7 131 2 or or CC cord-021424-kocwsyi7 131 3 non non JJ cord-021424-kocwsyi7 131 4 - - JJ cord-021424-kocwsyi7 131 5 virulent virulent JJ cord-021424-kocwsyi7 131 6 strains strain NNS cord-021424-kocwsyi7 131 7 of of IN cord-021424-kocwsyi7 131 8 specifi specifi NNS cord-021424-kocwsyi7 131 9 c c NN cord-021424-kocwsyi7 131 10 pathogens pathogen NNS cord-021424-kocwsyi7 131 11 as as RB cord-021424-kocwsyi7 131 12 well well RB cord-021424-kocwsyi7 131 13 as as IN cord-021424-kocwsyi7 131 14 mutant mutant JJ cord-021424-kocwsyi7 131 15 organisms organism NNS cord-021424-kocwsyi7 131 16 have have VBP cord-021424-kocwsyi7 131 17 been be VBN cord-021424-kocwsyi7 131 18 used use VBN cord-021424-kocwsyi7 131 19 to to TO cord-021424-kocwsyi7 131 20 determine determine VB cord-021424-kocwsyi7 131 21 the the DT cord-021424-kocwsyi7 131 22 gene gene NN cord-021424-kocwsyi7 131 23 expression expression NN cord-021424-kocwsyi7 131 24 profi profi NNP cord-021424-kocwsyi7 131 25 le le NNP cord-021424-kocwsyi7 131 26 associated associate VBN cord-021424-kocwsyi7 131 27 with with IN cord-021424-kocwsyi7 131 28 a a DT cord-021424-kocwsyi7 131 29 negative negative JJ cord-021424-kocwsyi7 131 30 or or CC cord-021424-kocwsyi7 131 31 positive positive JJ cord-021424-kocwsyi7 131 32 clinical clinical JJ cord-021424-kocwsyi7 131 33 outcome outcome NN cord-021424-kocwsyi7 131 34 . . . cord-021424-kocwsyi7 132 1 Few few JJ cord-021424-kocwsyi7 132 2 in in IN cord-021424-kocwsyi7 132 3 vivo vivo NN cord-021424-kocwsyi7 132 4 studies study NNS cord-021424-kocwsyi7 132 5 have have VBP cord-021424-kocwsyi7 132 6 been be VBN cord-021424-kocwsyi7 132 7 carried carry VBN cord-021424-kocwsyi7 132 8 out out RP cord-021424-kocwsyi7 132 9 and and CC cord-021424-kocwsyi7 132 10 have have VBP cord-021424-kocwsyi7 132 11 shed shed VBN cord-021424-kocwsyi7 132 12 light light NN cord-021424-kocwsyi7 132 13 on on IN cord-021424-kocwsyi7 132 14 the the DT cord-021424-kocwsyi7 132 15 more more RBR cord-021424-kocwsyi7 132 16 complex complex JJ cord-021424-kocwsyi7 132 17 responses response NNS cord-021424-kocwsyi7 132 18 seen see VBN cord-021424-kocwsyi7 132 19 in in IN cord-021424-kocwsyi7 132 20 whole whole JJ cord-021424-kocwsyi7 132 21 animals animal NNS cord-021424-kocwsyi7 132 22 and and CC cord-021424-kocwsyi7 132 23 helped help VBD cord-021424-kocwsyi7 132 24 to to TO cord-021424-kocwsyi7 132 25 validate validate VB cord-021424-kocwsyi7 132 26 the the DT cord-021424-kocwsyi7 132 27 in in FW cord-021424-kocwsyi7 132 28 vitro vitro FW cord-021424-kocwsyi7 132 29 data datum NNS cord-021424-kocwsyi7 132 30 . . . cord-021424-kocwsyi7 133 1 Several several JJ cord-021424-kocwsyi7 133 2 pioneering pioneering JJ cord-021424-kocwsyi7 133 3 studies study NNS cord-021424-kocwsyi7 133 4 demonstrated demonstrate VBD cord-021424-kocwsyi7 133 5 that that IN cord-021424-kocwsyi7 133 6 microarrays microarray NNS cord-021424-kocwsyi7 133 7 could could MD cord-021424-kocwsyi7 133 8 be be VB cord-021424-kocwsyi7 133 9 used use VBN cord-021424-kocwsyi7 133 10 to to TO cord-021424-kocwsyi7 133 11 determine determine VB cord-021424-kocwsyi7 133 12 changes change NNS cord-021424-kocwsyi7 133 13 in in IN cord-021424-kocwsyi7 133 14 the the DT cord-021424-kocwsyi7 133 15 gene gene NN cord-021424-kocwsyi7 133 16 expression expression NN cord-021424-kocwsyi7 133 17 profi profi NNP cord-021424-kocwsyi7 133 18 le le FW cord-021424-kocwsyi7 133 19 of of IN cord-021424-kocwsyi7 133 20 cells cell NNS cord-021424-kocwsyi7 133 21 in in IN cord-021424-kocwsyi7 133 22 response response NN cord-021424-kocwsyi7 133 23 to to IN cord-021424-kocwsyi7 133 24 virus virus NN cord-021424-kocwsyi7 133 25 or or CC cord-021424-kocwsyi7 133 26 bacterial bacterial JJ cord-021424-kocwsyi7 133 27 infection infection NN cord-021424-kocwsyi7 134 1 ( ( -LRB- cord-021424-kocwsyi7 134 2 Boldrick Boldrick NNP cord-021424-kocwsyi7 134 3 et et FW cord-021424-kocwsyi7 134 4 al al NNP cord-021424-kocwsyi7 134 5 . . NNP cord-021424-kocwsyi7 134 6 , , , cord-021424-kocwsyi7 134 7 2002 2002 CD cord-021424-kocwsyi7 135 1 ; ; : cord-021424-kocwsyi7 135 2 Gao Gao NNP cord-021424-kocwsyi7 135 3 et et NNP cord-021424-kocwsyi7 135 4 al al NNP cord-021424-kocwsyi7 135 5 . . . cord-021424-kocwsyi7 136 1 , , , cord-021424-kocwsyi7 136 2 2002 2002 CD cord-021424-kocwsyi7 136 3 ; ; : cord-021424-kocwsyi7 136 4 Huang Huang NNP cord-021424-kocwsyi7 136 5 et et NNP cord-021424-kocwsyi7 136 6 al al NNP cord-021424-kocwsyi7 136 7 . . NNP cord-021424-kocwsyi7 136 8 , , , cord-021424-kocwsyi7 136 9 2001 2001 CD cord-021424-kocwsyi7 136 10 ; ; : cord-021424-kocwsyi7 136 11 Nau Nau NNP cord-021424-kocwsyi7 136 12 et et NNP cord-021424-kocwsyi7 136 13 al al NNP cord-021424-kocwsyi7 136 14 . . NNP cord-021424-kocwsyi7 136 15 , , , cord-021424-kocwsyi7 136 16 2002 2002 CD cord-021424-kocwsyi7 136 17 ) ) -RRB- cord-021424-kocwsyi7 136 18 . . . cord-021424-kocwsyi7 137 1 These these DT cord-021424-kocwsyi7 137 2 studies study NNS cord-021424-kocwsyi7 137 3 paved pave VBD cord-021424-kocwsyi7 137 4 the the DT cord-021424-kocwsyi7 137 5 way way NN cord-021424-kocwsyi7 137 6 for for IN cord-021424-kocwsyi7 137 7 the the DT cord-021424-kocwsyi7 137 8 analysis analysis NN cord-021424-kocwsyi7 137 9 of of IN cord-021424-kocwsyi7 137 10 the the DT cord-021424-kocwsyi7 137 11 host host NN cord-021424-kocwsyi7 137 12 response response NN cord-021424-kocwsyi7 137 13 to to IN cord-021424-kocwsyi7 137 14 a a DT cord-021424-kocwsyi7 137 15 wide wide JJ cord-021424-kocwsyi7 137 16 variety variety NN cord-021424-kocwsyi7 137 17 of of IN cord-021424-kocwsyi7 137 18 infectious infectious JJ cord-021424-kocwsyi7 137 19 agents agent NNS cord-021424-kocwsyi7 137 20 . . . cord-021424-kocwsyi7 138 1 The the DT cord-021424-kocwsyi7 138 2 most most JJS cord-021424-kocwsyi7 138 3 signifi signifi NN cord-021424-kocwsyi7 138 4 ca can MD cord-021424-kocwsyi7 138 5 nt not RB cord-021424-kocwsyi7 138 6 of of IN cord-021424-kocwsyi7 138 7 these these DT cord-021424-kocwsyi7 138 8 studies study NNS cord-021424-kocwsyi7 138 9 compared compare VBD cord-021424-kocwsyi7 138 10 the the DT cord-021424-kocwsyi7 138 11 response response NN cord-021424-kocwsyi7 138 12 of of IN cord-021424-kocwsyi7 138 13 macrophages macrophage NNS cord-021424-kocwsyi7 138 14 or or CC cord-021424-kocwsyi7 138 15 DCs dc NNS cord-021424-kocwsyi7 138 16 to to IN cord-021424-kocwsyi7 138 17 a a DT cord-021424-kocwsyi7 138 18 variety variety NN cord-021424-kocwsyi7 138 19 of of IN cord-021424-kocwsyi7 138 20 infectious infectious JJ cord-021424-kocwsyi7 138 21 agents agent NNS cord-021424-kocwsyi7 138 22 in in IN cord-021424-kocwsyi7 138 23 a a DT cord-021424-kocwsyi7 138 24 single single JJ cord-021424-kocwsyi7 138 25 study study NN cord-021424-kocwsyi7 138 26 . . . cord-021424-kocwsyi7 139 1 In in IN cord-021424-kocwsyi7 139 2 these these DT cord-021424-kocwsyi7 139 3 studies study NNS cord-021424-kocwsyi7 139 4 a a DT cord-021424-kocwsyi7 139 5 strong strong JJ cord-021424-kocwsyi7 139 6 shared share VBN cord-021424-kocwsyi7 139 7 response response NN cord-021424-kocwsyi7 139 8 to to IN cord-021424-kocwsyi7 139 9 all all DT cord-021424-kocwsyi7 139 10 infections infection NNS cord-021424-kocwsyi7 139 11 , , , cord-021424-kocwsyi7 139 12 be be VB cord-021424-kocwsyi7 139 13 they -PRON- PRP cord-021424-kocwsyi7 139 14 bacterial bacterial JJ cord-021424-kocwsyi7 139 15 , , , cord-021424-kocwsyi7 139 16 viral viral JJ cord-021424-kocwsyi7 139 17 or or CC cord-021424-kocwsyi7 139 18 parasitic parasitic JJ cord-021424-kocwsyi7 139 19 in in IN cord-021424-kocwsyi7 139 20 nature nature NN cord-021424-kocwsyi7 139 21 , , , cord-021424-kocwsyi7 139 22 was be VBD cord-021424-kocwsyi7 139 23 identifi identifi NNP cord-021424-kocwsyi7 139 24 ed ed NNP cord-021424-kocwsyi7 139 25 . . . cord-021424-kocwsyi7 140 1 Not not RB cord-021424-kocwsyi7 140 2 only only RB cord-021424-kocwsyi7 140 3 was be VBD cord-021424-kocwsyi7 140 4 there there RB cord-021424-kocwsyi7 140 5 commonality commonality NN cord-021424-kocwsyi7 140 6 from from IN cord-021424-kocwsyi7 140 7 one one CD cord-021424-kocwsyi7 140 8 infectious infectious JJ cord-021424-kocwsyi7 140 9 agent agent NN cord-021424-kocwsyi7 140 10 to to IN cord-021424-kocwsyi7 140 11 another another DT cord-021424-kocwsyi7 141 1 but but CC cord-021424-kocwsyi7 141 2 there there EX cord-021424-kocwsyi7 141 3 was be VBD cord-021424-kocwsyi7 141 4 also also RB cord-021424-kocwsyi7 141 5 some some DT cord-021424-kocwsyi7 141 6 commonality commonality NN cord-021424-kocwsyi7 141 7 across across IN cord-021424-kocwsyi7 141 8 cell cell NN cord-021424-kocwsyi7 141 9 types type NNS cord-021424-kocwsyi7 141 10 . . . cord-021424-kocwsyi7 142 1 This this DT cord-021424-kocwsyi7 142 2 expression expression NN cord-021424-kocwsyi7 142 3 signature signature NN cord-021424-kocwsyi7 142 4 has have VBZ cord-021424-kocwsyi7 142 5 been be VBN cord-021424-kocwsyi7 142 6 interpreted interpret VBN cord-021424-kocwsyi7 142 7 as as IN cord-021424-kocwsyi7 142 8 a a DT cord-021424-kocwsyi7 142 9 general general JJ cord-021424-kocwsyi7 142 10 " " `` cord-021424-kocwsyi7 142 11 alarm alarm NN cord-021424-kocwsyi7 142 12 signal signal NN cord-021424-kocwsyi7 142 13 " " '' cord-021424-kocwsyi7 142 14 for for IN cord-021424-kocwsyi7 142 15 infection infection NN cord-021424-kocwsyi7 142 16 ( ( -LRB- cord-021424-kocwsyi7 142 17 reviewed review VBN cord-021424-kocwsyi7 142 18 in in IN cord-021424-kocwsyi7 142 19 [ [ -LRB- cord-021424-kocwsyi7 142 20 Jenner Jenner NNP cord-021424-kocwsyi7 142 21 and and CC cord-021424-kocwsyi7 142 22 Young Young NNP cord-021424-kocwsyi7 142 23 , , , cord-021424-kocwsyi7 142 24 2005 2005 CD cord-021424-kocwsyi7 142 25 ] ] -RRB- cord-021424-kocwsyi7 142 26 ) ) -RRB- cord-021424-kocwsyi7 142 27 . . . cord-021424-kocwsyi7 143 1 Studies study NNS cord-021424-kocwsyi7 143 2 of of IN cord-021424-kocwsyi7 143 3 infection infection NN cord-021424-kocwsyi7 143 4 with with IN cord-021424-kocwsyi7 143 5 Gram gram NN cord-021424-kocwsyi7 143 6 - - HYPH cord-021424-kocwsyi7 143 7 positive positive JJ cord-021424-kocwsyi7 143 8 and and CC cord-021424-kocwsyi7 143 9 Gram gram NN cord-021424-kocwsyi7 143 10 - - HYPH cord-021424-kocwsyi7 143 11 negative negative JJ cord-021424-kocwsyi7 143 12 bacteria bacteria NNS cord-021424-kocwsyi7 143 13 also also RB cord-021424-kocwsyi7 143 14 revealed reveal VBD cord-021424-kocwsyi7 143 15 a a DT cord-021424-kocwsyi7 143 16 common common JJ cord-021424-kocwsyi7 143 17 expression expression NN cord-021424-kocwsyi7 143 18 signature signature NN cord-021424-kocwsyi7 143 19 in in IN cord-021424-kocwsyi7 143 20 peripheral peripheral JJ cord-021424-kocwsyi7 143 21 blood blood NN cord-021424-kocwsyi7 143 22 mononuclear mononuclear NN cord-021424-kocwsyi7 143 23 cells cell NNS cord-021424-kocwsyi7 143 24 . . . cord-021424-kocwsyi7 144 1 Recently recently RB cord-021424-kocwsyi7 144 2 , , , cord-021424-kocwsyi7 144 3 the the DT cord-021424-kocwsyi7 144 4 Young Young NNP cord-021424-kocwsyi7 144 5 lab lab NN cord-021424-kocwsyi7 144 6 has have VBZ cord-021424-kocwsyi7 144 7 interrogated interrogate VBN cord-021424-kocwsyi7 144 8 all all DT cord-021424-kocwsyi7 144 9 of of IN cord-021424-kocwsyi7 144 10 the the DT cord-021424-kocwsyi7 144 11 publicly publicly RB cord-021424-kocwsyi7 144 12 available available JJ cord-021424-kocwsyi7 144 13 expression expression NN cord-021424-kocwsyi7 144 14 profi profi NNP cord-021424-kocwsyi7 144 15 ling ling NNP cord-021424-kocwsyi7 144 16 data datum NNS cord-021424-kocwsyi7 144 17 related relate VBN cord-021424-kocwsyi7 144 18 to to IN cord-021424-kocwsyi7 144 19 the the DT cord-021424-kocwsyi7 144 20 host host NN cord-021424-kocwsyi7 144 21 response response NN cord-021424-kocwsyi7 144 22 to to IN cord-021424-kocwsyi7 144 23 infection infection NN cord-021424-kocwsyi7 144 24 ( ( -LRB- cord-021424-kocwsyi7 144 25 Jenner Jenner NNP cord-021424-kocwsyi7 144 26 and and CC cord-021424-kocwsyi7 144 27 Young Young NNP cord-021424-kocwsyi7 144 28 , , , cord-021424-kocwsyi7 144 29 2005 2005 CD cord-021424-kocwsyi7 144 30 ) ) -RRB- cord-021424-kocwsyi7 144 31 . . . cord-021424-kocwsyi7 145 1 The the DT cord-021424-kocwsyi7 145 2 dataset dataset NN cord-021424-kocwsyi7 145 3 includes include VBZ cord-021424-kocwsyi7 145 4 785 785 CD cord-021424-kocwsyi7 145 5 experiments experiment NNS cord-021424-kocwsyi7 145 6 in in IN cord-021424-kocwsyi7 145 7 cells cell NNS cord-021424-kocwsyi7 145 8 ranging range VBG cord-021424-kocwsyi7 145 9 from from IN cord-021424-kocwsyi7 145 10 macrophages macrophage NNS cord-021424-kocwsyi7 145 11 and and CC cord-021424-kocwsyi7 145 12 DCs dc NNS cord-021424-kocwsyi7 145 13 to to IN cord-021424-kocwsyi7 145 14 cells cell NNS cord-021424-kocwsyi7 145 15 of of IN cord-021424-kocwsyi7 145 16 the the DT cord-021424-kocwsyi7 145 17 adaptive adaptive JJ cord-021424-kocwsyi7 145 18 immune immune JJ cord-021424-kocwsyi7 145 19 response response NN cord-021424-kocwsyi7 145 20 , , , cord-021424-kocwsyi7 145 21 endothelial endothelial JJ cord-021424-kocwsyi7 145 22 and and CC cord-021424-kocwsyi7 145 23 epithelial epithelial JJ cord-021424-kocwsyi7 145 24 cells cell NNS cord-021424-kocwsyi7 145 25 and and CC cord-021424-kocwsyi7 145 26 spanning span VBG cord-021424-kocwsyi7 145 27 a a DT cord-021424-kocwsyi7 145 28 wide wide JJ cord-021424-kocwsyi7 145 29 range range NN cord-021424-kocwsyi7 145 30 of of IN cord-021424-kocwsyi7 145 31 infecting infect VBG cord-021424-kocwsyi7 145 32 agents agent NNS cord-021424-kocwsyi7 145 33 . . . cord-021424-kocwsyi7 146 1 This this DT cord-021424-kocwsyi7 146 2 meta meta JJ cord-021424-kocwsyi7 146 3 - - HYPH cord-021424-kocwsyi7 146 4 analysis analysis NN cord-021424-kocwsyi7 146 5 revealed reveal VBD cord-021424-kocwsyi7 146 6 that that IN cord-021424-kocwsyi7 146 7 a a DT cord-021424-kocwsyi7 146 8 " " `` cord-021424-kocwsyi7 146 9 common common JJ cord-021424-kocwsyi7 146 10 host host NN cord-021424-kocwsyi7 146 11 response response NN cord-021424-kocwsyi7 146 12 " " `` cord-021424-kocwsyi7 146 13 can can MD cord-021424-kocwsyi7 146 14 be be VB cord-021424-kocwsyi7 146 15 detected detect VBN cord-021424-kocwsyi7 146 16 across across IN cord-021424-kocwsyi7 146 17 all all DT cord-021424-kocwsyi7 146 18 of of IN cord-021424-kocwsyi7 146 19 these these DT cord-021424-kocwsyi7 146 20 cell cell NN cord-021424-kocwsyi7 146 21 types type NNS cord-021424-kocwsyi7 146 22 and and CC cord-021424-kocwsyi7 146 23 infectious infectious JJ cord-021424-kocwsyi7 146 24 agents agent NNS cord-021424-kocwsyi7 146 25 and and CC cord-021424-kocwsyi7 146 26 show show VBP cord-021424-kocwsyi7 146 27 that that IN cord-021424-kocwsyi7 146 28 although although IN cord-021424-kocwsyi7 146 29 cells cell NNS cord-021424-kocwsyi7 146 30 such such JJ cord-021424-kocwsyi7 146 31 as as IN cord-021424-kocwsyi7 146 32 macrophages macrophage NNS cord-021424-kocwsyi7 146 33 and and CC cord-021424-kocwsyi7 146 34 DCs dc NNS cord-021424-kocwsyi7 146 35 specialize specialize VBP cord-021424-kocwsyi7 146 36 in in IN cord-021424-kocwsyi7 146 37 detecting detect VBG cord-021424-kocwsyi7 146 38 infection infection NN cord-021424-kocwsyi7 146 39 , , , cord-021424-kocwsyi7 146 40 other other JJ cord-021424-kocwsyi7 146 41 cells cell NNS cord-021424-kocwsyi7 146 42 of of IN cord-021424-kocwsyi7 146 43 the the DT cord-021424-kocwsyi7 146 44 body body NN cord-021424-kocwsyi7 146 45 can can MD cord-021424-kocwsyi7 146 46 mount mount VB cord-021424-kocwsyi7 146 47 the the DT cord-021424-kocwsyi7 146 48 same same JJ cord-021424-kocwsyi7 146 49 " " `` cord-021424-kocwsyi7 146 50 alarm alarm NN cord-021424-kocwsyi7 146 51 response response NN cord-021424-kocwsyi7 146 52 " " '' cord-021424-kocwsyi7 146 53 as as IN cord-021424-kocwsyi7 146 54 described describe VBN cord-021424-kocwsyi7 146 55 above above RB cord-021424-kocwsyi7 146 56 ( ( -LRB- cord-021424-kocwsyi7 146 57 Figure figure NN cord-021424-kocwsyi7 146 58 107.1 107.1 CD cord-021424-kocwsyi7 146 59 ) ) -RRB- cord-021424-kocwsyi7 146 60 . . . cord-021424-kocwsyi7 147 1 Not not RB cord-021424-kocwsyi7 147 2 surprisingly surprisingly RB cord-021424-kocwsyi7 147 3 this this DT cord-021424-kocwsyi7 147 4 expression expression NN cord-021424-kocwsyi7 147 5 signature signature NN cord-021424-kocwsyi7 147 6 contains contain VBZ cord-021424-kocwsyi7 147 7 many many JJ cord-021424-kocwsyi7 147 8 genes gene NNS cord-021424-kocwsyi7 147 9 associated associate VBN cord-021424-kocwsyi7 147 10 with with IN cord-021424-kocwsyi7 147 11 the the DT cord-021424-kocwsyi7 147 12 immune immune JJ cord-021424-kocwsyi7 147 13 system system NN cord-021424-kocwsyi7 147 14 particularly particularly RB cord-021424-kocwsyi7 147 15 those those DT cord-021424-kocwsyi7 147 16 encoding encode VBG cord-021424-kocwsyi7 147 17 infl infl NNP cord-021424-kocwsyi7 147 18 ammatory ammatory NNP cord-021424-kocwsyi7 147 19 cytokines cytokine NNS cord-021424-kocwsyi7 147 20 , , , cord-021424-kocwsyi7 147 21 chemokines chemokine NNS cord-021424-kocwsyi7 147 22 and and CC cord-021424-kocwsyi7 147 23 their -PRON- PRP$ cord-021424-kocwsyi7 147 24 receptors receptor NNS cord-021424-kocwsyi7 147 25 . . . cord-021424-kocwsyi7 148 1 However however RB cord-021424-kocwsyi7 148 2 , , , cord-021424-kocwsyi7 148 3 some some DT cord-021424-kocwsyi7 148 4 more more RBR cord-021424-kocwsyi7 148 5 surprising surprising JJ cord-021424-kocwsyi7 148 6 patterns pattern NNS cord-021424-kocwsyi7 148 7 of of IN cord-021424-kocwsyi7 148 8 expression expression NN cord-021424-kocwsyi7 148 9 were be VBD cord-021424-kocwsyi7 148 10 also also RB cord-021424-kocwsyi7 148 11 detected detect VBN cord-021424-kocwsyi7 148 12 . . . cord-021424-kocwsyi7 149 1 It -PRON- PRP cord-021424-kocwsyi7 149 2 has have VBZ cord-021424-kocwsyi7 149 3 been be VBN cord-021424-kocwsyi7 149 4 long long RB cord-021424-kocwsyi7 149 5 known know VBN cord-021424-kocwsyi7 149 6 that that IN cord-021424-kocwsyi7 149 7 interferon interferon NN cord-021424-kocwsyi7 149 8 - - HYPH cord-021424-kocwsyi7 149 9 stimulated stimulate VBN cord-021424-kocwsyi7 149 10 genes gene NNS cord-021424-kocwsyi7 149 11 ( ( -LRB- cord-021424-kocwsyi7 149 12 ISGs ISGs NNP cord-021424-kocwsyi7 149 13 ) ) -RRB- cord-021424-kocwsyi7 149 14 are be VBP cord-021424-kocwsyi7 149 15 regulated regulate VBN cord-021424-kocwsyi7 149 16 by by IN cord-021424-kocwsyi7 149 17 virus virus NN cord-021424-kocwsyi7 149 18 infection infection NN cord-021424-kocwsyi7 149 19 , , , cord-021424-kocwsyi7 149 20 but but CC cord-021424-kocwsyi7 149 21 it -PRON- PRP cord-021424-kocwsyi7 149 22 has have VBZ cord-021424-kocwsyi7 149 23 only only RB cord-021424-kocwsyi7 149 24 recently recently RB cord-021424-kocwsyi7 149 25 been be VBN cord-021424-kocwsyi7 149 26 recognized recognize VBN cord-021424-kocwsyi7 149 27 that that IN cord-021424-kocwsyi7 149 28 bacteria bacteria NNS cord-021424-kocwsyi7 149 29 and and CC cord-021424-kocwsyi7 149 30 other other JJ cord-021424-kocwsyi7 149 31 infecting infect VBG cord-021424-kocwsyi7 149 32 agents agent NNS cord-021424-kocwsyi7 149 33 can can MD cord-021424-kocwsyi7 149 34 also also RB cord-021424-kocwsyi7 149 35 illicit illicit JJ cord-021424-kocwsyi7 149 36 the the DT cord-021424-kocwsyi7 149 37 interferon interferon NN cord-021424-kocwsyi7 149 38 response response NN cord-021424-kocwsyi7 149 39 . . . cord-021424-kocwsyi7 150 1 This this DT cord-021424-kocwsyi7 150 2 was be VBD cord-021424-kocwsyi7 150 3 borne bear VBN cord-021424-kocwsyi7 150 4 out out RP cord-021424-kocwsyi7 150 5 in in IN cord-021424-kocwsyi7 150 6 these these DT cord-021424-kocwsyi7 150 7 meta meta NNP cord-021424-kocwsyi7 150 8 - - HYPH cord-021424-kocwsyi7 150 9 analyses analysis NNS cord-021424-kocwsyi7 150 10 where where WRB cord-021424-kocwsyi7 150 11 upregulation upregulation NN cord-021424-kocwsyi7 150 12 of of IN cord-021424-kocwsyi7 150 13 an an DT cord-021424-kocwsyi7 150 14 ISG ISG NNP cord-021424-kocwsyi7 150 15 set set NN cord-021424-kocwsyi7 150 16 is be VBZ cord-021424-kocwsyi7 150 17 observed observe VBN cord-021424-kocwsyi7 150 18 across across IN cord-021424-kocwsyi7 150 19 a a DT cord-021424-kocwsyi7 150 20 broad broad JJ cord-021424-kocwsyi7 150 21 range range NN cord-021424-kocwsyi7 150 22 of of IN cord-021424-kocwsyi7 150 23 infecting infect VBG cord-021424-kocwsyi7 150 24 agents agent NNS cord-021424-kocwsyi7 150 25 and and CC cord-021424-kocwsyi7 150 26 cell cell NN cord-021424-kocwsyi7 150 27 types type NNS cord-021424-kocwsyi7 150 28 . . . cord-021424-kocwsyi7 151 1 Not not RB cord-021424-kocwsyi7 151 2 only only RB cord-021424-kocwsyi7 151 3 do do VBP cord-021424-kocwsyi7 151 4 these these DT cord-021424-kocwsyi7 151 5 cells cell NNS cord-021424-kocwsyi7 151 6 change change VB cord-021424-kocwsyi7 151 7 the the DT cord-021424-kocwsyi7 151 8 expression expression NN cord-021424-kocwsyi7 151 9 of of IN cord-021424-kocwsyi7 151 10 secreted secrete VBN cord-021424-kocwsyi7 151 11 factors factor NNS cord-021424-kocwsyi7 151 12 and and CC cord-021424-kocwsyi7 151 13 their -PRON- PRP$ cord-021424-kocwsyi7 151 14 receptors receptor NNS cord-021424-kocwsyi7 151 15 during during IN cord-021424-kocwsyi7 151 16 infection infection NN cord-021424-kocwsyi7 151 17 but but CC cord-021424-kocwsyi7 151 18 the the DT cord-021424-kocwsyi7 151 19 intracellular intracellular JJ cord-021424-kocwsyi7 151 20 milieu milieu NN cord-021424-kocwsyi7 151 21 is be VBZ cord-021424-kocwsyi7 151 22 also also RB cord-021424-kocwsyi7 151 23 modifi modifi JJ cord-021424-kocwsyi7 151 24 ed ed NN cord-021424-kocwsyi7 151 25 . . . cord-021424-kocwsyi7 152 1 Once once RB cord-021424-kocwsyi7 152 2 again again RB cord-021424-kocwsyi7 152 3 , , , cord-021424-kocwsyi7 152 4 there there EX cord-021424-kocwsyi7 152 5 is be VBZ cord-021424-kocwsyi7 152 6 a a DT cord-021424-kocwsyi7 152 7 common common JJ cord-021424-kocwsyi7 152 8 pattern pattern NN cord-021424-kocwsyi7 152 9 of of IN cord-021424-kocwsyi7 152 10 change change NN cord-021424-kocwsyi7 152 11 observed observe VBN cord-021424-kocwsyi7 152 12 in in IN cord-021424-kocwsyi7 152 13 all all DT cord-021424-kocwsyi7 152 14 of of IN cord-021424-kocwsyi7 152 15 these these DT cord-021424-kocwsyi7 152 16 studies study NNS cord-021424-kocwsyi7 152 17 . . . cord-021424-kocwsyi7 153 1 The the DT cord-021424-kocwsyi7 153 2 upregulation upregulation NN cord-021424-kocwsyi7 153 3 of of IN cord-021424-kocwsyi7 153 4 signaling signal VBG cord-021424-kocwsyi7 153 5 and and CC cord-021424-kocwsyi7 153 6 transcription transcription NN cord-021424-kocwsyi7 153 7 pathways pathway NNS cord-021424-kocwsyi7 153 8 that that WDT cord-021424-kocwsyi7 153 9 both both DT cord-021424-kocwsyi7 153 10 augment augment VBP cord-021424-kocwsyi7 153 11 and and CC cord-021424-kocwsyi7 153 12 attenuate attenuate VB cord-021424-kocwsyi7 153 13 the the DT cord-021424-kocwsyi7 153 14 immune immune JJ cord-021424-kocwsyi7 153 15 response response NN cord-021424-kocwsyi7 153 16 are be VBP cord-021424-kocwsyi7 153 17 observed observe VBN cord-021424-kocwsyi7 153 18 leading lead VBG cord-021424-kocwsyi7 153 19 to to IN cord-021424-kocwsyi7 153 20 the the DT cord-021424-kocwsyi7 153 21 interpretation interpretation NN cord-021424-kocwsyi7 153 22 that that IN cord-021424-kocwsyi7 153 23 both both CC cord-021424-kocwsyi7 153 24 positive positive JJ cord-021424-kocwsyi7 153 25 and and CC cord-021424-kocwsyi7 153 26 negative negative JJ cord-021424-kocwsyi7 153 27 feedback feedback NN cord-021424-kocwsyi7 153 28 loops loop NNS cord-021424-kocwsyi7 153 29 operate operate VBP cord-021424-kocwsyi7 153 30 within within IN cord-021424-kocwsyi7 153 31 the the DT cord-021424-kocwsyi7 153 32 cell cell NN cord-021424-kocwsyi7 153 33 to to TO cord-021424-kocwsyi7 153 34 heighten heighten VB cord-021424-kocwsyi7 153 35 or or CC cord-021424-kocwsyi7 153 36 dampen dampen VB cord-021424-kocwsyi7 153 37 the the DT cord-021424-kocwsyi7 153 38 immune immune JJ cord-021424-kocwsyi7 153 39 response response NN cord-021424-kocwsyi7 153 40 . . . cord-021424-kocwsyi7 154 1 Temporal temporal JJ cord-021424-kocwsyi7 154 2 profi profi NNP cord-021424-kocwsyi7 154 3 ling ling NNP cord-021424-kocwsyi7 154 4 can can MD cord-021424-kocwsyi7 154 5 reveal reveal VB cord-021424-kocwsyi7 154 6 extra extra JJ cord-021424-kocwsyi7 154 7 layers layer NNS cord-021424-kocwsyi7 154 8 of of IN cord-021424-kocwsyi7 154 9 complexity complexity NN cord-021424-kocwsyi7 154 10 and and CC cord-021424-kocwsyi7 154 11 in in IN cord-021424-kocwsyi7 154 12 one one CD cord-021424-kocwsyi7 154 13 study study NN cord-021424-kocwsyi7 154 14 a a DT cord-021424-kocwsyi7 154 15 pro pro JJ cord-021424-kocwsyi7 154 16 - - JJ cord-021424-kocwsyi7 154 17 infl infl JJ cord-021424-kocwsyi7 154 18 ammatory ammatory FW cord-021424-kocwsyi7 154 19 profi profi NNP cord-021424-kocwsyi7 154 20 le le NNP cord-021424-kocwsyi7 154 21 followed follow VBN cord-021424-kocwsyi7 154 22 by by IN cord-021424-kocwsyi7 154 23 an an DT cord-021424-kocwsyi7 154 24 anti anti JJ cord-021424-kocwsyi7 154 25 - - JJ cord-021424-kocwsyi7 154 26 infl infl JJ cord-021424-kocwsyi7 154 27 ammatory ammatory FW cord-021424-kocwsyi7 154 28 profi profi NNP cord-021424-kocwsyi7 154 29 le le NNP cord-021424-kocwsyi7 155 1 was be VBD cord-021424-kocwsyi7 155 2 identifi identifi NNP cord-021424-kocwsyi7 155 3 ed ed NNP cord-021424-kocwsyi7 155 4 in in IN cord-021424-kocwsyi7 155 5 macrophages macrophage NNS cord-021424-kocwsyi7 155 6 activated activate VBN cord-021424-kocwsyi7 155 7 with with IN cord-021424-kocwsyi7 155 8 LPS LPS NNP cord-021424-kocwsyi7 155 9 ( ( -LRB- cord-021424-kocwsyi7 155 10 Wells Wells NNP cord-021424-kocwsyi7 155 11 et et NNP cord-021424-kocwsyi7 155 12 al al NNP cord-021424-kocwsyi7 155 13 . . NNP cord-021424-kocwsyi7 155 14 , , , cord-021424-kocwsyi7 155 15 2005 2005 CD cord-021424-kocwsyi7 155 16 ) ) -RRB- cord-021424-kocwsyi7 155 17 . . . cord-021424-kocwsyi7 156 1 Meta Meta NNP cord-021424-kocwsyi7 156 2 - - HYPH cord-021424-kocwsyi7 156 3 analysis analysis NN cord-021424-kocwsyi7 156 4 of of IN cord-021424-kocwsyi7 156 5 temporal temporal JJ cord-021424-kocwsyi7 156 6 studies study NNS cord-021424-kocwsyi7 156 7 of of IN cord-021424-kocwsyi7 156 8 activation activation NN cord-021424-kocwsyi7 156 9 through through IN cord-021424-kocwsyi7 156 10 different different JJ cord-021424-kocwsyi7 156 11 TLRs tlr NNS cord-021424-kocwsyi7 156 12 also also RB cord-021424-kocwsyi7 156 13 revealed reveal VBD cord-021424-kocwsyi7 156 14 that that IN cord-021424-kocwsyi7 156 15 the the DT cord-021424-kocwsyi7 156 16 infl infl NNP cord-021424-kocwsyi7 156 17 ammatory ammatory NNP cord-021424-kocwsyi7 156 18 chemokines chemokines NNPS cord-021424-kocwsyi7 156 19 / / SYM cord-021424-kocwsyi7 156 20 cytokine cytokine NN cord-021424-kocwsyi7 156 21 signature signature NN cord-021424-kocwsyi7 156 22 was be VBD cord-021424-kocwsyi7 156 23 an an DT cord-021424-kocwsyi7 156 24 early early JJ cord-021424-kocwsyi7 156 25 response response NN cord-021424-kocwsyi7 156 26 while while IN cord-021424-kocwsyi7 156 27 the the DT cord-021424-kocwsyi7 156 28 ISG ISG NNP cord-021424-kocwsyi7 156 29 response response NN cord-021424-kocwsyi7 156 30 was be VBD cord-021424-kocwsyi7 156 31 later later RB cord-021424-kocwsyi7 156 32 , , , cord-021424-kocwsyi7 156 33 presumably presumably RB cord-021424-kocwsyi7 156 34 refl refl NNP cord-021424-kocwsyi7 156 35 ecting ecte VBG cord-021424-kocwsyi7 156 36 the the DT cord-021424-kocwsyi7 156 37 need need NN cord-021424-kocwsyi7 156 38 for for IN cord-021424-kocwsyi7 156 39 an an DT cord-021424-kocwsyi7 156 40 indirect indirect JJ cord-021424-kocwsyi7 156 41 activation activation NN cord-021424-kocwsyi7 156 42 of of IN cord-021424-kocwsyi7 156 43 the the DT cord-021424-kocwsyi7 156 44 ISGs ISGs NNPS cord-021424-kocwsyi7 156 45 through through IN cord-021424-kocwsyi7 156 46 interferon interferon NN cord-021424-kocwsyi7 156 47 production production NN cord-021424-kocwsyi7 156 48 ( ( -LRB- cord-021424-kocwsyi7 156 49 Jenner Jenner NNP cord-021424-kocwsyi7 156 50 and and CC cord-021424-kocwsyi7 156 51 Young Young NNP cord-021424-kocwsyi7 156 52 , , , cord-021424-kocwsyi7 156 53 2005 2005 CD cord-021424-kocwsyi7 156 54 ) ) -RRB- cord-021424-kocwsyi7 156 55 . . . cord-021424-kocwsyi7 157 1 Changes change NNS cord-021424-kocwsyi7 157 2 in in IN cord-021424-kocwsyi7 157 3 the the DT cord-021424-kocwsyi7 157 4 expression expression NN cord-021424-kocwsyi7 157 5 level level NN cord-021424-kocwsyi7 157 6 of of IN cord-021424-kocwsyi7 157 7 genes gene NNS cord-021424-kocwsyi7 157 8 involved involve VBN cord-021424-kocwsyi7 157 9 in in IN cord-021424-kocwsyi7 157 10 both both DT cord-021424-kocwsyi7 157 11 activation activation NN cord-021424-kocwsyi7 157 12 and and CC cord-021424-kocwsyi7 157 13 repression repression NN cord-021424-kocwsyi7 157 14 of of IN cord-021424-kocwsyi7 157 15 apoptosis apoptosis NN cord-021424-kocwsyi7 157 16 also also RB cord-021424-kocwsyi7 157 17 fall fall VBP cord-021424-kocwsyi7 157 18 under under IN cord-021424-kocwsyi7 157 19 the the DT cord-021424-kocwsyi7 157 20 " " `` cord-021424-kocwsyi7 157 21 common common JJ cord-021424-kocwsyi7 157 22 signature signature NN cord-021424-kocwsyi7 157 23 " " '' cord-021424-kocwsyi7 157 24 banner banner NN cord-021424-kocwsyi7 157 25 and and CC cord-021424-kocwsyi7 157 26 this this DT cord-021424-kocwsyi7 157 27 is be VBZ cord-021424-kocwsyi7 157 28 interpreted interpret VBN cord-021424-kocwsyi7 157 29 as as IN cord-021424-kocwsyi7 157 30 sending send VBG cord-021424-kocwsyi7 157 31 the the DT cord-021424-kocwsyi7 157 32 cells cell NNS cord-021424-kocwsyi7 157 33 into into IN cord-021424-kocwsyi7 157 34 a a DT cord-021424-kocwsyi7 157 35 state state NN cord-021424-kocwsyi7 157 36 of of IN cord-021424-kocwsyi7 157 37 high high JJ cord-021424-kocwsyi7 157 38 alert alert NN cord-021424-kocwsyi7 157 39 where where WRB cord-021424-kocwsyi7 157 40 apoptosis apoptosis NN cord-021424-kocwsyi7 157 41 can can MD cord-021424-kocwsyi7 157 42 be be VB cord-021424-kocwsyi7 157 43 either either CC cord-021424-kocwsyi7 157 44 initiated initiate VBN cord-021424-kocwsyi7 157 45 to to TO cord-021424-kocwsyi7 157 46 eliminate eliminate VB cord-021424-kocwsyi7 157 47 infected infected JJ cord-021424-kocwsyi7 157 48 cells cell NNS cord-021424-kocwsyi7 157 49 or or CC cord-021424-kocwsyi7 157 50 terminated terminate VBN cord-021424-kocwsyi7 157 51 if if IN cord-021424-kocwsyi7 157 52 the the DT cord-021424-kocwsyi7 157 53 infection infection NN cord-021424-kocwsyi7 157 54 resolves resolve VBZ cord-021424-kocwsyi7 157 55 ( ( -LRB- cord-021424-kocwsyi7 157 56 Jenner Jenner NNP cord-021424-kocwsyi7 157 57 and and CC cord-021424-kocwsyi7 157 58 Young Young NNP cord-021424-kocwsyi7 157 59 , , , cord-021424-kocwsyi7 157 60 2005 2005 CD cord-021424-kocwsyi7 157 61 ) ) -RRB- cord-021424-kocwsyi7 157 62 . . . cord-021424-kocwsyi7 158 1 Although although IN cord-021424-kocwsyi7 158 2 these these DT cord-021424-kocwsyi7 158 3 in in IN cord-021424-kocwsyi7 158 4 vitro vitro FW cord-021424-kocwsyi7 158 5 studies study NNS cord-021424-kocwsyi7 158 6 have have VBP cord-021424-kocwsyi7 158 7 provided provide VBN cord-021424-kocwsyi7 158 8 an an DT cord-021424-kocwsyi7 158 9 overview overview NN cord-021424-kocwsyi7 158 10 of of IN cord-021424-kocwsyi7 158 11 the the DT cord-021424-kocwsyi7 158 12 response response NN cord-021424-kocwsyi7 158 13 of of IN cord-021424-kocwsyi7 158 14 isolated isolated JJ cord-021424-kocwsyi7 158 15 cell cell NN cord-021424-kocwsyi7 158 16 types type NNS cord-021424-kocwsyi7 158 17 to to IN cord-021424-kocwsyi7 158 18 pathogenic pathogenic JJ cord-021424-kocwsyi7 158 19 infection infection NN cord-021424-kocwsyi7 158 20 , , , cord-021424-kocwsyi7 158 21 in in IN cord-021424-kocwsyi7 158 22 vivo vivo NNP cord-021424-kocwsyi7 158 23 studies study NNS cord-021424-kocwsyi7 158 24 are be VBP cord-021424-kocwsyi7 158 25 needed need VBN cord-021424-kocwsyi7 158 26 to to TO cord-021424-kocwsyi7 158 27 validate validate VB cord-021424-kocwsyi7 158 28 any any DT cord-021424-kocwsyi7 158 29 of of IN cord-021424-kocwsyi7 158 30 these these DT cord-021424-kocwsyi7 158 31 results result NNS cord-021424-kocwsyi7 158 32 before before IN cord-021424-kocwsyi7 158 33 application application NN cord-021424-kocwsyi7 158 34 to to IN cord-021424-kocwsyi7 158 35 clinical clinical JJ cord-021424-kocwsyi7 158 36 medicine medicine NN cord-021424-kocwsyi7 158 37 . . . cord-021424-kocwsyi7 159 1 A a DT cord-021424-kocwsyi7 159 2 number number NN cord-021424-kocwsyi7 159 3 of of IN cord-021424-kocwsyi7 159 4 animal animal NN cord-021424-kocwsyi7 159 5 models model NNS cord-021424-kocwsyi7 159 6 have have VBP cord-021424-kocwsyi7 159 7 been be VBN cord-021424-kocwsyi7 159 8 used use VBN cord-021424-kocwsyi7 159 9 to to IN cord-021424-kocwsyi7 159 10 profi profi NNP cord-021424-kocwsyi7 159 11 le le NNP cord-021424-kocwsyi7 159 12 the the DT cord-021424-kocwsyi7 159 13 host host NN cord-021424-kocwsyi7 159 14 response response NN cord-021424-kocwsyi7 159 15 to to IN cord-021424-kocwsyi7 159 16 infection infection NN cord-021424-kocwsyi7 159 17 with with IN cord-021424-kocwsyi7 159 18 a a DT cord-021424-kocwsyi7 159 19 variety variety NN cord-021424-kocwsyi7 159 20 of of IN cord-021424-kocwsyi7 159 21 agents agent NNS cord-021424-kocwsyi7 159 22 . . . cord-021424-kocwsyi7 160 1 These these DT cord-021424-kocwsyi7 160 2 studies study NNS cord-021424-kocwsyi7 160 3 are be VBP cord-021424-kocwsyi7 160 4 complicated complicate VBN cord-021424-kocwsyi7 160 5 especially especially RB cord-021424-kocwsyi7 160 6 if if IN cord-021424-kocwsyi7 160 7 whole whole JJ cord-021424-kocwsyi7 160 8 tissue tissue NN cord-021424-kocwsyi7 160 9 samples sample NNS cord-021424-kocwsyi7 160 10 are be VBP cord-021424-kocwsyi7 160 11 used use VBN cord-021424-kocwsyi7 160 12 in in IN cord-021424-kocwsyi7 160 13 that that DT cord-021424-kocwsyi7 160 14 changes change NNS cord-021424-kocwsyi7 160 15 in in IN cord-021424-kocwsyi7 160 16 gene gene NN cord-021424-kocwsyi7 160 17 expression expression NN cord-021424-kocwsyi7 160 18 can can MD cord-021424-kocwsyi7 160 19 result result VB cord-021424-kocwsyi7 160 20 not not RB cord-021424-kocwsyi7 160 21 only only RB cord-021424-kocwsyi7 160 22 from from IN cord-021424-kocwsyi7 160 23 genuine genuine JJ cord-021424-kocwsyi7 160 24 changes change NNS cord-021424-kocwsyi7 160 25 within within IN cord-021424-kocwsyi7 160 26 the the DT cord-021424-kocwsyi7 160 27 cells cell NNS cord-021424-kocwsyi7 160 28 of of IN cord-021424-kocwsyi7 160 29 the the DT cord-021424-kocwsyi7 160 30 tissue tissue NN cord-021424-kocwsyi7 160 31 but but CC cord-021424-kocwsyi7 160 32 also also RB cord-021424-kocwsyi7 160 33 from from IN cord-021424-kocwsyi7 160 34 the the DT cord-021424-kocwsyi7 160 35 recruitment recruitment NN cord-021424-kocwsyi7 160 36 especially especially RB cord-021424-kocwsyi7 160 37 of of IN cord-021424-kocwsyi7 160 38 immune immune JJ cord-021424-kocwsyi7 160 39 cells cell NNS cord-021424-kocwsyi7 160 40 into into IN cord-021424-kocwsyi7 160 41 the the DT cord-021424-kocwsyi7 160 42 infected infected JJ cord-021424-kocwsyi7 160 43 or or CC cord-021424-kocwsyi7 160 44 infl infl NNP cord-021424-kocwsyi7 160 45 amed amed NNP cord-021424-kocwsyi7 160 46 tissue tissue NN cord-021424-kocwsyi7 160 47 . . . cord-021424-kocwsyi7 161 1 Nevertheless nevertheless RB cord-021424-kocwsyi7 161 2 , , , cord-021424-kocwsyi7 161 3 in in IN cord-021424-kocwsyi7 161 4 vivo vivo NN cord-021424-kocwsyi7 161 5 studies study NNS cord-021424-kocwsyi7 161 6 have have VBP cord-021424-kocwsyi7 161 7 , , , cord-021424-kocwsyi7 161 8 in in IN cord-021424-kocwsyi7 161 9 some some DT cord-021424-kocwsyi7 161 10 cases case NNS cord-021424-kocwsyi7 161 11 , , , cord-021424-kocwsyi7 161 12 shown show VBN cord-021424-kocwsyi7 161 13 good good JJ cord-021424-kocwsyi7 161 14 correlation correlation NN cord-021424-kocwsyi7 161 15 with with IN cord-021424-kocwsyi7 161 16 the the DT cord-021424-kocwsyi7 161 17 expression expression NN cord-021424-kocwsyi7 161 18 profi profi NNP cord-021424-kocwsyi7 161 19 les les NNP cord-021424-kocwsyi7 161 20 found find VBN cord-021424-kocwsyi7 161 21 from from IN cord-021424-kocwsyi7 161 22 in in IN cord-021424-kocwsyi7 161 23 vitro vitro FW cord-021424-kocwsyi7 161 24 studies study NNS cord-021424-kocwsyi7 161 25 . . . cord-021424-kocwsyi7 162 1 For for IN cord-021424-kocwsyi7 162 2 example example NN cord-021424-kocwsyi7 162 3 , , , cord-021424-kocwsyi7 162 4 profi profi NNP cord-021424-kocwsyi7 162 5 ling ling NNP cord-021424-kocwsyi7 162 6 the the DT cord-021424-kocwsyi7 162 7 brains brain NNS cord-021424-kocwsyi7 162 8 of of IN cord-021424-kocwsyi7 162 9 mice mouse NNS cord-021424-kocwsyi7 162 10 infected infect VBN cord-021424-kocwsyi7 162 11 with with IN cord-021424-kocwsyi7 162 12 virulent virulent JJ cord-021424-kocwsyi7 162 13 Sindbis Sindbis NNP cord-021424-kocwsyi7 162 14 virus virus NN cord-021424-kocwsyi7 162 15 revealed reveal VBD cord-021424-kocwsyi7 162 16 that that IN cord-021424-kocwsyi7 162 17 ISGs ISGs NNPS cord-021424-kocwsyi7 162 18 as as RB cord-021424-kocwsyi7 162 19 well well RB cord-021424-kocwsyi7 162 20 as as IN cord-021424-kocwsyi7 162 21 infl infl NNP cord-021424-kocwsyi7 162 22 ammatory ammatory NNP cord-021424-kocwsyi7 162 23 chemokines chemokine NNS cord-021424-kocwsyi7 162 24 were be VBD cord-021424-kocwsyi7 162 25 upregulated upregulate VBN cord-021424-kocwsyi7 162 26 ( ( -LRB- cord-021424-kocwsyi7 162 27 Johnston Johnston NNP cord-021424-kocwsyi7 162 28 et et NNP cord-021424-kocwsyi7 162 29 al al NNP cord-021424-kocwsyi7 162 30 . . NNP cord-021424-kocwsyi7 162 31 , , , cord-021424-kocwsyi7 162 32 2001 2001 CD cord-021424-kocwsyi7 162 33 ) ) -RRB- cord-021424-kocwsyi7 162 34 and and CC cord-021424-kocwsyi7 162 35 in in IN cord-021424-kocwsyi7 162 36 terms term NNS cord-021424-kocwsyi7 162 37 of of IN cord-021424-kocwsyi7 162 38 diagnosis diagnosis NN cord-021424-kocwsyi7 162 39 or or CC cord-021424-kocwsyi7 162 40 treatment treatment NN cord-021424-kocwsyi7 162 41 the the DT cord-021424-kocwsyi7 162 42 exact exact JJ cord-021424-kocwsyi7 162 43 reason reason NN cord-021424-kocwsyi7 162 44 behind behind IN cord-021424-kocwsyi7 162 45 these these DT cord-021424-kocwsyi7 162 46 changes change NNS cord-021424-kocwsyi7 162 47 in in IN cord-021424-kocwsyi7 162 48 expression expression NN cord-021424-kocwsyi7 162 49 signature signature NN cord-021424-kocwsyi7 162 50 may may MD cord-021424-kocwsyi7 162 51 be be VB cord-021424-kocwsyi7 162 52 irrelevant irrelevant JJ cord-021424-kocwsyi7 162 53 . . . cord-021424-kocwsyi7 163 1 In in IN cord-021424-kocwsyi7 163 2 vivo vivo NNP cord-021424-kocwsyi7 163 3 studies study NNS cord-021424-kocwsyi7 163 4 also also RB cord-021424-kocwsyi7 163 5 have have VBP cord-021424-kocwsyi7 163 6 some some DT cord-021424-kocwsyi7 163 7 advantages advantage NNS cord-021424-kocwsyi7 163 8 in in IN cord-021424-kocwsyi7 163 9 that that IN cord-021424-kocwsyi7 163 10 the the DT cord-021424-kocwsyi7 163 11 gene gene NN cord-021424-kocwsyi7 163 12 expression expression NN cord-021424-kocwsyi7 163 13 profi profi NNP cord-021424-kocwsyi7 163 14 les les NNP cord-021424-kocwsyi7 163 15 detected detect VBN cord-021424-kocwsyi7 163 16 in in IN cord-021424-kocwsyi7 163 17 infected infected JJ cord-021424-kocwsyi7 163 18 tissues tissue NNS cord-021424-kocwsyi7 163 19 will will MD cord-021424-kocwsyi7 163 20 often often RB cord-021424-kocwsyi7 163 21 make make VB cord-021424-kocwsyi7 163 22 more more JJR cord-021424-kocwsyi7 163 23 sense sense NN cord-021424-kocwsyi7 163 24 when when WRB cord-021424-kocwsyi7 163 25 combined combine VBN cord-021424-kocwsyi7 163 26 with with IN cord-021424-kocwsyi7 163 27 other other JJ cord-021424-kocwsyi7 163 28 physiological physiological JJ cord-021424-kocwsyi7 163 29 or or CC cord-021424-kocwsyi7 163 30 cell cell NN cord-021424-kocwsyi7 163 31 biology biology NN cord-021424-kocwsyi7 163 32 data datum NNS cord-021424-kocwsyi7 163 33 from from IN cord-021424-kocwsyi7 163 34 studies study NNS cord-021424-kocwsyi7 163 35 of of IN cord-021424-kocwsyi7 163 36 the the DT cord-021424-kocwsyi7 163 37 infected infected JJ cord-021424-kocwsyi7 163 38 host host NN cord-021424-kocwsyi7 163 39 . . . cord-021424-kocwsyi7 164 1 Thus thus RB cord-021424-kocwsyi7 164 2 an an DT cord-021424-kocwsyi7 164 3 " " `` cord-021424-kocwsyi7 164 4 infection infection NN cord-021424-kocwsyi7 164 5 signature signature NN cord-021424-kocwsyi7 164 6 " " '' cord-021424-kocwsyi7 164 7 would would MD cord-021424-kocwsyi7 164 8 not not RB cord-021424-kocwsyi7 164 9 only only RB cord-021424-kocwsyi7 164 10 describe describe VB cord-021424-kocwsyi7 164 11 the the DT cord-021424-kocwsyi7 164 12 altered alter VBN cord-021424-kocwsyi7 164 13 gene gene NN cord-021424-kocwsyi7 164 14 expression expression NN cord-021424-kocwsyi7 164 15 of of IN cord-021424-kocwsyi7 164 16 the the DT cord-021424-kocwsyi7 164 17 immune immune JJ cord-021424-kocwsyi7 164 18 cells cell NNS cord-021424-kocwsyi7 164 19 that that WDT cord-021424-kocwsyi7 164 20 are be VBP cord-021424-kocwsyi7 164 21 recruited recruit VBN cord-021424-kocwsyi7 164 22 to to IN cord-021424-kocwsyi7 164 23 the the DT cord-021424-kocwsyi7 164 24 sites site NNS cord-021424-kocwsyi7 164 25 of of IN cord-021424-kocwsyi7 164 26 infection infection NN cord-021424-kocwsyi7 164 27 but but CC cord-021424-kocwsyi7 164 28 also also RB cord-021424-kocwsyi7 164 29 would would MD cord-021424-kocwsyi7 164 30 include include VB cord-021424-kocwsyi7 164 31 changes change NNS cord-021424-kocwsyi7 164 32 in in IN cord-021424-kocwsyi7 164 33 the the DT cord-021424-kocwsyi7 164 34 gene gene NN cord-021424-kocwsyi7 164 35 expression expression NN cord-021424-kocwsyi7 164 36 of of IN cord-021424-kocwsyi7 164 37 the the DT cord-021424-kocwsyi7 164 38 resident resident JJ cord-021424-kocwsyi7 164 39 cells cell NNS cord-021424-kocwsyi7 164 40 of of IN cord-021424-kocwsyi7 164 41 the the DT cord-021424-kocwsyi7 164 42 tissue tissue NN cord-021424-kocwsyi7 164 43 and and CC cord-021424-kocwsyi7 164 44 may may MD cord-021424-kocwsyi7 164 45 provide provide VB cord-021424-kocwsyi7 164 46 a a DT cord-021424-kocwsyi7 164 47 more more RBR cord-021424-kocwsyi7 164 48 robust robust JJ cord-021424-kocwsyi7 164 49 profi profi NNP cord-021424-kocwsyi7 164 50 le le FW cord-021424-kocwsyi7 164 51 of of IN cord-021424-kocwsyi7 164 52 the the DT cord-021424-kocwsyi7 164 53 infection infection NN cord-021424-kocwsyi7 164 54 process process NN cord-021424-kocwsyi7 164 55 for for IN cord-021424-kocwsyi7 164 56 use use NN cord-021424-kocwsyi7 164 57 in in IN cord-021424-kocwsyi7 164 58 diagnostic diagnostic JJ cord-021424-kocwsyi7 164 59 applications application NNS cord-021424-kocwsyi7 164 60 . . . cord-021424-kocwsyi7 165 1 What what WP cord-021424-kocwsyi7 165 2 can can MD cord-021424-kocwsyi7 165 3 be be VB cord-021424-kocwsyi7 165 4 applied apply VBN cord-021424-kocwsyi7 165 5 to to IN cord-021424-kocwsyi7 165 6 clinical clinical JJ cord-021424-kocwsyi7 165 7 medicine medicine NN cord-021424-kocwsyi7 165 8 from from IN cord-021424-kocwsyi7 165 9 these these DT cord-021424-kocwsyi7 165 10 studies study NNS cord-021424-kocwsyi7 165 11 ? ? . cord-021424-kocwsyi7 166 1 The the DT cord-021424-kocwsyi7 166 2 ability ability NN cord-021424-kocwsyi7 166 3 to to TO cord-021424-kocwsyi7 166 4 detect detect VB cord-021424-kocwsyi7 166 5 an an DT cord-021424-kocwsyi7 166 6 " " `` cord-021424-kocwsyi7 166 7 infection infection NN cord-021424-kocwsyi7 166 8 signature signature NN cord-021424-kocwsyi7 166 9 " " '' cord-021424-kocwsyi7 166 10 using use VBG cord-021424-kocwsyi7 166 11 focused focused JJ cord-021424-kocwsyi7 166 12 microarrays microarray NNS cord-021424-kocwsyi7 166 13 could could MD cord-021424-kocwsyi7 166 14 potentially potentially RB cord-021424-kocwsyi7 166 15 be be VB cord-021424-kocwsyi7 166 16 used use VBN cord-021424-kocwsyi7 166 17 as as IN cord-021424-kocwsyi7 166 18 a a DT cord-021424-kocwsyi7 166 19 diagnostic diagnostic JJ cord-021424-kocwsyi7 166 20 tool tool NN cord-021424-kocwsyi7 166 21 . . . cord-021424-kocwsyi7 167 1 There there EX cord-021424-kocwsyi7 167 2 would would MD cord-021424-kocwsyi7 167 3 be be VB cord-021424-kocwsyi7 167 4 an an DT cord-021424-kocwsyi7 167 5 immediate immediate JJ cord-021424-kocwsyi7 167 6 need need NN cord-021424-kocwsyi7 167 7 to to TO cord-021424-kocwsyi7 167 8 identify identify VB cord-021424-kocwsyi7 167 9 a a DT cord-021424-kocwsyi7 167 10 core core NN cord-021424-kocwsyi7 167 11 set set NN cord-021424-kocwsyi7 167 12 of of IN cord-021424-kocwsyi7 167 13 genes gene NNS cord-021424-kocwsyi7 167 14 with with IN cord-021424-kocwsyi7 167 15 suffi suffi NNP cord-021424-kocwsyi7 167 16 ciently ciently RB cord-021424-kocwsyi7 167 17 robust robust JJ cord-021424-kocwsyi7 167 18 changes change NNS cord-021424-kocwsyi7 167 19 in in IN cord-021424-kocwsyi7 167 20 gene gene NN cord-021424-kocwsyi7 167 21 expression expression NN cord-021424-kocwsyi7 167 22 to to TO cord-021424-kocwsyi7 167 23 form form VB cord-021424-kocwsyi7 167 24 the the DT cord-021424-kocwsyi7 167 25 basis basis NN cord-021424-kocwsyi7 167 26 of of IN cord-021424-kocwsyi7 167 27 a a DT cord-021424-kocwsyi7 167 28 diagnostic diagnostic JJ cord-021424-kocwsyi7 167 29 array array NN cord-021424-kocwsyi7 167 30 . . . cord-021424-kocwsyi7 168 1 Arraying array VBG cord-021424-kocwsyi7 168 2 technology technology NN cord-021424-kocwsyi7 168 3 would would MD cord-021424-kocwsyi7 168 4 need need VB cord-021424-kocwsyi7 168 5 to to TO cord-021424-kocwsyi7 168 6 be be VB cord-021424-kocwsyi7 168 7 priced price VBN cord-021424-kocwsyi7 168 8 for for IN cord-021424-kocwsyi7 168 9 diagnostic diagnostic JJ cord-021424-kocwsyi7 168 10 use use NN cord-021424-kocwsyi7 168 11 and and CC cord-021424-kocwsyi7 168 12 the the DT cord-021424-kocwsyi7 168 13 technology technology NN cord-021424-kocwsyi7 168 14 would would MD cord-021424-kocwsyi7 168 15 have have VB cord-021424-kocwsyi7 168 16 to to TO cord-021424-kocwsyi7 168 17 be be VB cord-021424-kocwsyi7 168 18 deemed deem VBN cord-021424-kocwsyi7 168 19 suffi suffi NNP cord-021424-kocwsyi7 168 20 ciently ciently RB cord-021424-kocwsyi7 168 21 robust robust JJ cord-021424-kocwsyi7 168 22 to to TO cord-021424-kocwsyi7 168 23 pass pass VB cord-021424-kocwsyi7 168 24 all all PDT cord-021424-kocwsyi7 168 25 the the DT cord-021424-kocwsyi7 168 26 quality quality NN cord-021424-kocwsyi7 168 27 control control NN cord-021424-kocwsyi7 168 28 requirements requirement NNS cord-021424-kocwsyi7 168 29 of of IN cord-021424-kocwsyi7 168 30 a a DT cord-021424-kocwsyi7 168 31 diagnostic diagnostic JJ cord-021424-kocwsyi7 168 32 laboratory laboratory NN cord-021424-kocwsyi7 168 33 . . . cord-021424-kocwsyi7 169 1 No no DT cord-021424-kocwsyi7 169 2 doubt doubt RB cord-021424-kocwsyi7 169 3 progress progress NN cord-021424-kocwsyi7 169 4 will will MD cord-021424-kocwsyi7 169 5 be be VB cord-021424-kocwsyi7 169 6 made make VBN cord-021424-kocwsyi7 169 7 toward toward IN cord-021424-kocwsyi7 169 8 these these DT cord-021424-kocwsyi7 169 9 goals goal NNS cord-021424-kocwsyi7 169 10 in in IN cord-021424-kocwsyi7 169 11 the the DT cord-021424-kocwsyi7 169 12 near near JJ cord-021424-kocwsyi7 169 13 future future NN cord-021424-kocwsyi7 169 14 . . . cord-021424-kocwsyi7 170 1 In in IN cord-021424-kocwsyi7 170 2 addition addition NN cord-021424-kocwsyi7 170 3 to to IN cord-021424-kocwsyi7 170 4 the the DT cord-021424-kocwsyi7 170 5 " " `` cord-021424-kocwsyi7 170 6 common common JJ cord-021424-kocwsyi7 170 7 host host NN cord-021424-kocwsyi7 170 8 response response NN cord-021424-kocwsyi7 170 9 " " '' cord-021424-kocwsyi7 170 10 described describe VBN cord-021424-kocwsyi7 170 11 above above RB cord-021424-kocwsyi7 170 12 , , , cord-021424-kocwsyi7 170 13 microarray microarray NN cord-021424-kocwsyi7 170 14 studies study NNS cord-021424-kocwsyi7 170 15 have have VBP cord-021424-kocwsyi7 170 16 revealed reveal VBN cord-021424-kocwsyi7 170 17 that that IN cord-021424-kocwsyi7 170 18 pathogen pathogen NN cord-021424-kocwsyi7 170 19 - - HYPH cord-021424-kocwsyi7 170 20 specifi specifi VBN cord-021424-kocwsyi7 170 21 c c NN cord-021424-kocwsyi7 170 22 responses response NNS cord-021424-kocwsyi7 170 23 also also RB cord-021424-kocwsyi7 170 24 exist exist VBP cord-021424-kocwsyi7 170 25 . . . cord-021424-kocwsyi7 171 1 This this DT cord-021424-kocwsyi7 171 2 is be VBZ cord-021424-kocwsyi7 171 3 not not RB cord-021424-kocwsyi7 171 4 surprising surprising JJ cord-021424-kocwsyi7 171 5 since since IN cord-021424-kocwsyi7 171 6 it -PRON- PRP cord-021424-kocwsyi7 171 7 has have VBZ cord-021424-kocwsyi7 171 8 long long RB cord-021424-kocwsyi7 171 9 been be VBN cord-021424-kocwsyi7 171 10 known know VBN cord-021424-kocwsyi7 171 11 that that IN cord-021424-kocwsyi7 171 12 different different JJ cord-021424-kocwsyi7 171 13 pathogens pathogen NNS cord-021424-kocwsyi7 171 14 induce induce VBP cord-021424-kocwsyi7 171 15 distinct distinct JJ cord-021424-kocwsyi7 171 16 arms arm NNS cord-021424-kocwsyi7 171 17 of of IN cord-021424-kocwsyi7 171 18 the the DT cord-021424-kocwsyi7 171 19 adaptive adaptive JJ cord-021424-kocwsyi7 171 20 immune immune JJ cord-021424-kocwsyi7 171 21 response response NN cord-021424-kocwsyi7 171 22 . . . cord-021424-kocwsyi7 172 1 For for IN cord-021424-kocwsyi7 172 2 example example NN cord-021424-kocwsyi7 172 3 , , , cord-021424-kocwsyi7 172 4 distinct distinct JJ cord-021424-kocwsyi7 172 5 types type NNS cord-021424-kocwsyi7 172 6 of of IN cord-021424-kocwsyi7 172 7 helper helper NN cord-021424-kocwsyi7 172 8 T t NN cord-021424-kocwsyi7 172 9 cells cell NNS cord-021424-kocwsyi7 172 10 are be VBP cord-021424-kocwsyi7 172 11 activated activate VBN cord-021424-kocwsyi7 172 12 in in IN cord-021424-kocwsyi7 172 13 response response NN cord-021424-kocwsyi7 172 14 to to IN cord-021424-kocwsyi7 172 15 bacterial bacterial JJ cord-021424-kocwsyi7 172 16 and and CC cord-021424-kocwsyi7 172 17 viral viral JJ cord-021424-kocwsyi7 172 18 infection infection NN cord-021424-kocwsyi7 172 19 compared compare VBN cord-021424-kocwsyi7 172 20 to to IN cord-021424-kocwsyi7 172 21 parasite parasite NN cord-021424-kocwsyi7 172 22 infection infection NN cord-021424-kocwsyi7 172 23 and and CC cord-021424-kocwsyi7 172 24 DC DC NNP cord-021424-kocwsyi7 172 25 products product NNS cord-021424-kocwsyi7 172 26 such such JJ cord-021424-kocwsyi7 172 27 as as IN cord-021424-kocwsyi7 172 28 cytokines cytokine NNS cord-021424-kocwsyi7 172 29 and and CC cord-021424-kocwsyi7 172 30 chemokines chemokine NNS cord-021424-kocwsyi7 172 31 control control VBP cord-021424-kocwsyi7 172 32 the the DT cord-021424-kocwsyi7 172 33 differentiation differentiation NN cord-021424-kocwsyi7 172 34 of of IN cord-021424-kocwsyi7 172 35 T T NNP cord-021424-kocwsyi7 172 36 helper helper NN cord-021424-kocwsyi7 172 37 cell cell NN cord-021424-kocwsyi7 172 38 into into IN cord-021424-kocwsyi7 172 39 the the DT cord-021424-kocwsyi7 172 40 correct correct JJ cord-021424-kocwsyi7 172 41 response response NN cord-021424-kocwsyi7 172 42 type type NN cord-021424-kocwsyi7 172 43 ( ( -LRB- cord-021424-kocwsyi7 172 44 Mosmann Mosmann NNP cord-021424-kocwsyi7 172 45 et et NNP cord-021424-kocwsyi7 172 46 al al NNP cord-021424-kocwsyi7 172 47 . . NNP cord-021424-kocwsyi7 172 48 , , , cord-021424-kocwsyi7 172 49 2005 2005 CD cord-021424-kocwsyi7 172 50 ) ) -RRB- cord-021424-kocwsyi7 172 51 . . . cord-021424-kocwsyi7 173 1 Thus thus RB cord-021424-kocwsyi7 173 2 , , , cord-021424-kocwsyi7 173 3 the the DT cord-021424-kocwsyi7 173 4 fact fact NN cord-021424-kocwsyi7 173 5 that that IN cord-021424-kocwsyi7 173 6 cells cell NNS cord-021424-kocwsyi7 173 7 of of IN cord-021424-kocwsyi7 173 8 the the DT cord-021424-kocwsyi7 173 9 innate innate JJ cord-021424-kocwsyi7 173 10 immune immune JJ cord-021424-kocwsyi7 173 11 system system NN cord-021424-kocwsyi7 173 12 display display VBP cord-021424-kocwsyi7 173 13 a a DT cord-021424-kocwsyi7 173 14 pathogenspecifi pathogenspecifi NN cord-021424-kocwsyi7 173 15 c c NNP cord-021424-kocwsyi7 173 16 transcriptional transcriptional JJ cord-021424-kocwsyi7 173 17 response response NN cord-021424-kocwsyi7 173 18 as as RB cord-021424-kocwsyi7 173 19 well well RB cord-021424-kocwsyi7 173 20 as as IN cord-021424-kocwsyi7 173 21 a a DT cord-021424-kocwsyi7 173 22 general general JJ cord-021424-kocwsyi7 173 23 alarm alarm NN cord-021424-kocwsyi7 173 24 signal signal NN cord-021424-kocwsyi7 173 25 helps help VBZ cord-021424-kocwsyi7 173 26 to to TO cord-021424-kocwsyi7 173 27 dictate dictate VB cord-021424-kocwsyi7 173 28 the the DT cord-021424-kocwsyi7 173 29 subsequent subsequent JJ cord-021424-kocwsyi7 173 30 immune immune JJ cord-021424-kocwsyi7 173 31 response response NN cord-021424-kocwsyi7 173 32 . . . cord-021424-kocwsyi7 174 1 Different different JJ cord-021424-kocwsyi7 174 2 TLRs tlr NNS cord-021424-kocwsyi7 174 3 are be VBP cord-021424-kocwsyi7 174 4 involved involve VBN cord-021424-kocwsyi7 174 5 in in IN cord-021424-kocwsyi7 174 6 recognizing recognize VBG cord-021424-kocwsyi7 174 7 and and CC cord-021424-kocwsyi7 174 8 responding respond VBG cord-021424-kocwsyi7 174 9 to to IN cord-021424-kocwsyi7 174 10 different different JJ cord-021424-kocwsyi7 174 11 pathogens pathogen NNS cord-021424-kocwsyi7 174 12 . . . cord-021424-kocwsyi7 175 1 For for IN cord-021424-kocwsyi7 175 2 example example NN cord-021424-kocwsyi7 175 3 , , , cord-021424-kocwsyi7 175 4 TLR2 TLR2 NNP cord-021424-kocwsyi7 175 5 is be VBZ cord-021424-kocwsyi7 175 6 responsible responsible JJ cord-021424-kocwsyi7 175 7 for for IN cord-021424-kocwsyi7 175 8 activation activation NN cord-021424-kocwsyi7 175 9 in in IN cord-021424-kocwsyi7 175 10 response response NN cord-021424-kocwsyi7 175 11 to to IN cord-021424-kocwsyi7 175 12 Gram gram NN cord-021424-kocwsyi7 175 13 - - HYPH cord-021424-kocwsyi7 175 14 positive positive JJ cord-021424-kocwsyi7 175 15 bacteria bacteria NNS cord-021424-kocwsyi7 175 16 while while IN cord-021424-kocwsyi7 175 17 TLR4 TLR4 NNP cord-021424-kocwsyi7 175 18 responds respond VBZ cord-021424-kocwsyi7 175 19 to to IN cord-021424-kocwsyi7 175 20 LPS LPS NNP cord-021424-kocwsyi7 175 21 , , , cord-021424-kocwsyi7 175 22 a a DT cord-021424-kocwsyi7 175 23 component component NN cord-021424-kocwsyi7 175 24 of of IN cord-021424-kocwsyi7 175 25 Gram gram NN cord-021424-kocwsyi7 175 26 - - HYPH cord-021424-kocwsyi7 175 27 negative negative JJ cord-021424-kocwsyi7 175 28 bacteria bacteria NNS cord-021424-kocwsyi7 175 29 ( ( -LRB- cord-021424-kocwsyi7 175 30 Beutler Beutler NNP cord-021424-kocwsyi7 175 31 and and CC cord-021424-kocwsyi7 175 32 Rietschel Rietschel NNP cord-021424-kocwsyi7 175 33 , , , cord-021424-kocwsyi7 175 34 2003 2003 CD cord-021424-kocwsyi7 175 35 ; ; : cord-021424-kocwsyi7 175 36 . . . cord-021424-kocwsyi7 176 1 TLR3 TLR3 NNP cord-021424-kocwsyi7 176 2 responds respond VBZ cord-021424-kocwsyi7 176 3 to to IN cord-021424-kocwsyi7 176 4 dsRNA dsRNA NNS cord-021424-kocwsyi7 176 5 and and CC cord-021424-kocwsyi7 176 6 thus thus RB cord-021424-kocwsyi7 176 7 dictates dictate VBZ cord-021424-kocwsyi7 176 8 the the DT cord-021424-kocwsyi7 176 9 viral viral JJ cord-021424-kocwsyi7 176 10 immune immune JJ cord-021424-kocwsyi7 176 11 response response NN cord-021424-kocwsyi7 176 12 for for IN cord-021424-kocwsyi7 176 13 many many JJ cord-021424-kocwsyi7 176 14 dsRNA dsrna NN cord-021424-kocwsyi7 176 15 viruses virus NNS cord-021424-kocwsyi7 176 16 ( ( -LRB- cord-021424-kocwsyi7 176 17 Beutler Beutler NNP cord-021424-kocwsyi7 176 18 and and CC cord-021424-kocwsyi7 176 19 Rietschel Rietschel NNP cord-021424-kocwsyi7 176 20 , , , cord-021424-kocwsyi7 176 21 2003 2003 CD cord-021424-kocwsyi7 176 22 ; ; : cord-021424-kocwsyi7 176 23 . . . cord-021424-kocwsyi7 177 1 Studies study NNS cord-021424-kocwsyi7 177 2 using use VBG cord-021424-kocwsyi7 177 3 bacterial bacterial JJ cord-021424-kocwsyi7 177 4 components component NNS cord-021424-kocwsyi7 177 5 such such JJ cord-021424-kocwsyi7 177 6 as as IN cord-021424-kocwsyi7 177 7 LPS LPS NNP cord-021424-kocwsyi7 177 8 and and CC cord-021424-kocwsyi7 177 9 fl fl NNP cord-021424-kocwsyi7 177 10 agellin agellin NNP cord-021424-kocwsyi7 177 11 as as RB cord-021424-kocwsyi7 177 12 well well RB cord-021424-kocwsyi7 177 13 as as IN cord-021424-kocwsyi7 177 14 dsRNA dsRNA NNS cord-021424-kocwsyi7 177 15 have have VBP cord-021424-kocwsyi7 177 16 revealed reveal VBN cord-021424-kocwsyi7 177 17 that that IN cord-021424-kocwsyi7 177 18 each each DT cord-021424-kocwsyi7 177 19 TLR TLR NNP cord-021424-kocwsyi7 177 20 induces induce VBZ cord-021424-kocwsyi7 177 21 a a DT cord-021424-kocwsyi7 177 22 specifi specifi NN cord-021424-kocwsyi7 177 23 c c NN cord-021424-kocwsyi7 177 24 as as RB cord-021424-kocwsyi7 177 25 well well RB cord-021424-kocwsyi7 177 26 as as IN cord-021424-kocwsyi7 177 27 general general JJ cord-021424-kocwsyi7 177 28 transcriptional transcriptional JJ cord-021424-kocwsyi7 177 29 response response NN cord-021424-kocwsyi7 177 30 . . . cord-021424-kocwsyi7 178 1 The the DT cord-021424-kocwsyi7 178 2 transcriptional transcriptional JJ cord-021424-kocwsyi7 178 3 response response NN cord-021424-kocwsyi7 178 4 of of IN cord-021424-kocwsyi7 178 5 macrophages macrophage NNS cord-021424-kocwsyi7 178 6 and and CC cord-021424-kocwsyi7 178 7 peripheral peripheral JJ cord-021424-kocwsyi7 178 8 blood blood NN cord-021424-kocwsyi7 178 9 mononuclear mononuclear NN cord-021424-kocwsyi7 178 10 cells cell NNS cord-021424-kocwsyi7 178 11 is be VBZ cord-021424-kocwsyi7 178 12 more more RBR cord-021424-kocwsyi7 178 13 robust robust JJ cord-021424-kocwsyi7 178 14 in in IN cord-021424-kocwsyi7 178 15 response response NN cord-021424-kocwsyi7 178 16 to to IN cord-021424-kocwsyi7 178 17 Gram gram NN cord-021424-kocwsyi7 178 18 - - HYPH cord-021424-kocwsyi7 178 19 negative negative JJ cord-021424-kocwsyi7 178 20 ( ( -LRB- cord-021424-kocwsyi7 178 21 TLR4 TLR4 NNP cord-021424-kocwsyi7 178 22 ) ) -RRB- cord-021424-kocwsyi7 178 23 compared compare VBN cord-021424-kocwsyi7 178 24 with with IN cord-021424-kocwsyi7 178 25 Gram gram NN cord-021424-kocwsyi7 178 26 - - HYPH cord-021424-kocwsyi7 178 27 positive positive JJ cord-021424-kocwsyi7 178 28 ( ( -LRB- cord-021424-kocwsyi7 178 29 TLR2 TLR2 NNP cord-021424-kocwsyi7 178 30 ) ) -RRB- cord-021424-kocwsyi7 178 31 bacteria bacteria NNS cord-021424-kocwsyi7 178 32 and and CC cord-021424-kocwsyi7 178 33 the the DT cord-021424-kocwsyi7 178 34 ISG ISG NNP cord-021424-kocwsyi7 178 35 response response NN cord-021424-kocwsyi7 178 36 is be VBZ cord-021424-kocwsyi7 178 37 considerably considerably RB cord-021424-kocwsyi7 178 38 reduced reduce VBN cord-021424-kocwsyi7 178 39 for for IN cord-021424-kocwsyi7 178 40 the the DT cord-021424-kocwsyi7 178 41 Gram Gram NNP cord-021424-kocwsyi7 178 42 - - HYPH cord-021424-kocwsyi7 178 43 positive positive JJ cord-021424-kocwsyi7 178 44 expression expression NN cord-021424-kocwsyi7 178 45 signature signature NN cord-021424-kocwsyi7 178 46 ( ( -LRB- cord-021424-kocwsyi7 178 47 Boldrick Boldrick NNP cord-021424-kocwsyi7 178 48 et et FW cord-021424-kocwsyi7 178 49 al al NNP cord-021424-kocwsyi7 178 50 . . NNP cord-021424-kocwsyi7 178 51 , , , cord-021424-kocwsyi7 178 52 2002 2002 CD cord-021424-kocwsyi7 178 53 ; ; : cord-021424-kocwsyi7 178 54 Nau Nau NNP cord-021424-kocwsyi7 178 55 et et NNP cord-021424-kocwsyi7 178 56 al al NNP cord-021424-kocwsyi7 178 57 . . NNP cord-021424-kocwsyi7 178 58 , , , cord-021424-kocwsyi7 178 59 2002 2002 CD cord-021424-kocwsyi7 178 60 ) ) -RRB- cord-021424-kocwsyi7 178 61 . . . cord-021424-kocwsyi7 179 1 These these DT cord-021424-kocwsyi7 179 2 differences difference NNS cord-021424-kocwsyi7 179 3 are be VBP cord-021424-kocwsyi7 179 4 further further RB cord-021424-kocwsyi7 179 5 observed observe VBN cord-021424-kocwsyi7 179 6 when when WRB cord-021424-kocwsyi7 179 7 bacterial bacterial JJ cord-021424-kocwsyi7 179 8 components component NNS cord-021424-kocwsyi7 179 9 are be VBP cord-021424-kocwsyi7 179 10 used use VBN cord-021424-kocwsyi7 179 11 to to TO cord-021424-kocwsyi7 179 12 activate activate VB cord-021424-kocwsyi7 179 13 cells cell NNS cord-021424-kocwsyi7 179 14 . . . cord-021424-kocwsyi7 180 1 For for IN cord-021424-kocwsyi7 180 2 example example NN cord-021424-kocwsyi7 180 3 , , , cord-021424-kocwsyi7 180 4 LPS LPS NNP cord-021424-kocwsyi7 180 5 from from IN cord-021424-kocwsyi7 180 6 Gram gram NN cord-021424-kocwsyi7 180 7 - - HYPH cord-021424-kocwsyi7 180 8 negative negative JJ cord-021424-kocwsyi7 180 9 bacteria bacteria NNS cord-021424-kocwsyi7 180 10 , , , cord-021424-kocwsyi7 180 11 a a DT cord-021424-kocwsyi7 180 12 specifi specifi NN cord-021424-kocwsyi7 180 13 c c NN cord-021424-kocwsyi7 180 14 ligand ligand NN cord-021424-kocwsyi7 180 15 for for IN cord-021424-kocwsyi7 180 16 TLR4 TLR4 NNP cord-021424-kocwsyi7 180 17 , , , cord-021424-kocwsyi7 180 18 can can MD cord-021424-kocwsyi7 180 19 activate activate VB cord-021424-kocwsyi7 180 20 the the DT cord-021424-kocwsyi7 180 21 ISG ISG NNP cord-021424-kocwsyi7 180 22 profi profi NNP cord-021424-kocwsyi7 180 23 le le NNP cord-021424-kocwsyi7 180 24 but but CC cord-021424-kocwsyi7 180 25 TLR2 TLR2 NNP cord-021424-kocwsyi7 180 26 ligands ligand NNS cord-021424-kocwsyi7 180 27 such such JJ cord-021424-kocwsyi7 180 28 as as IN cord-021424-kocwsyi7 180 29 LTA LTA NNP cord-021424-kocwsyi7 180 30 and and CC cord-021424-kocwsyi7 180 31 MDP MDP NNP cord-021424-kocwsyi7 180 32 can can MD cord-021424-kocwsyi7 180 33 not not RB cord-021424-kocwsyi7 180 34 ( ( -LRB- cord-021424-kocwsyi7 180 35 Jenner Jenner NNP cord-021424-kocwsyi7 180 36 and and CC cord-021424-kocwsyi7 180 37 Young Young NNP cord-021424-kocwsyi7 180 38 , , , cord-021424-kocwsyi7 180 39 2005 2005 CD cord-021424-kocwsyi7 180 40 ) ) -RRB- cord-021424-kocwsyi7 180 41 . . . cord-021424-kocwsyi7 181 1 Not not RB cord-021424-kocwsyi7 181 2 only only RB cord-021424-kocwsyi7 181 3 the the DT cord-021424-kocwsyi7 181 4 activation activation NN cord-021424-kocwsyi7 181 5 of of IN cord-021424-kocwsyi7 181 6 specifi specifi NNP cord-021424-kocwsyi7 181 7 c c NN cord-021424-kocwsyi7 181 8 gene gene NN cord-021424-kocwsyi7 181 9 sets set NNS cord-021424-kocwsyi7 181 10 but but CC cord-021424-kocwsyi7 181 11 also also RB cord-021424-kocwsyi7 181 12 the the DT cord-021424-kocwsyi7 181 13 strength strength NN cord-021424-kocwsyi7 181 14 of of IN cord-021424-kocwsyi7 181 15 the the DT cord-021424-kocwsyi7 181 16 specifi specifi NNP cord-021424-kocwsyi7 181 17 c c NNP cord-021424-kocwsyi7 181 18 response response NN cord-021424-kocwsyi7 181 19 signature signature NN cord-021424-kocwsyi7 181 20 may may MD cord-021424-kocwsyi7 181 21 be be VB cord-021424-kocwsyi7 181 22 important important JJ cord-021424-kocwsyi7 181 23 for for IN cord-021424-kocwsyi7 181 24 the the DT cord-021424-kocwsyi7 181 25 immune immune JJ cord-021424-kocwsyi7 181 26 detection detection NN cord-021424-kocwsyi7 181 27 of of IN cord-021424-kocwsyi7 181 28 the the DT cord-021424-kocwsyi7 181 29 type type NN cord-021424-kocwsyi7 181 30 of of IN cord-021424-kocwsyi7 181 31 pathogen pathogen NN cord-021424-kocwsyi7 181 32 involved involve VBN cord-021424-kocwsyi7 181 33 . . . cord-021424-kocwsyi7 182 1 E. E. NNP cord-021424-kocwsyi7 182 2 coli coli VBZ cord-021424-kocwsyi7 182 3 infection infection NN cord-021424-kocwsyi7 182 4 of of IN cord-021424-kocwsyi7 182 5 DCs DCs NNP cord-021424-kocwsyi7 182 6 strongly strongly RB cord-021424-kocwsyi7 182 7 upregulates upregulate VBZ cord-021424-kocwsyi7 182 8 the the DT cord-021424-kocwsyi7 182 9 chemokines chemokine NNS cord-021424-kocwsyi7 182 10 / / SYM cord-021424-kocwsyi7 182 11 cytokine cytokine NN cord-021424-kocwsyi7 182 12 infl infl NNP cord-021424-kocwsyi7 182 13 ammatory ammatory NNP cord-021424-kocwsyi7 182 14 cluster cluster NN cord-021424-kocwsyi7 182 15 whereas whereas IN cord-021424-kocwsyi7 182 16 infection infection NN cord-021424-kocwsyi7 182 17 with with IN cord-021424-kocwsyi7 182 18 infl infl NN cord-021424-kocwsyi7 182 19 uenza uenza NNP cord-021424-kocwsyi7 182 20 or or CC cord-021424-kocwsyi7 182 21 other other JJ cord-021424-kocwsyi7 182 22 single single JJ cord-021424-kocwsyi7 182 23 stranded stranded JJ cord-021424-kocwsyi7 182 24 ( ( -LRB- cord-021424-kocwsyi7 182 25 ss ss NNP cord-021424-kocwsyi7 182 26 ) ) -RRB- cord-021424-kocwsyi7 182 27 RNA RNA NNP cord-021424-kocwsyi7 182 28 viruses virus NNS cord-021424-kocwsyi7 182 29 ( ( -LRB- cord-021424-kocwsyi7 182 30 through through IN cord-021424-kocwsyi7 182 31 TLR7 TLR7 NNP cord-021424-kocwsyi7 182 32 ) ) -RRB- cord-021424-kocwsyi7 182 33 has have VBZ cord-021424-kocwsyi7 182 34 a a DT cord-021424-kocwsyi7 182 35 weaker weak JJR cord-021424-kocwsyi7 182 36 ability ability NN cord-021424-kocwsyi7 182 37 to to TO cord-021424-kocwsyi7 182 38 regulate regulate VB cord-021424-kocwsyi7 182 39 this this DT cord-021424-kocwsyi7 182 40 cluster cluster NN cord-021424-kocwsyi7 182 41 but but CC cord-021424-kocwsyi7 182 42 a a DT cord-021424-kocwsyi7 182 43 stronger strong JJR cord-021424-kocwsyi7 182 44 ability ability NN cord-021424-kocwsyi7 182 45 to to TO cord-021424-kocwsyi7 182 46 regulate regulate VB cord-021424-kocwsyi7 182 47 the the DT cord-021424-kocwsyi7 182 48 ISG ISG NNP cord-021424-kocwsyi7 182 49 signature signature NN cord-021424-kocwsyi7 182 50 ( ( -LRB- cord-021424-kocwsyi7 182 51 Huang Huang NNP cord-021424-kocwsyi7 182 52 et et NNP cord-021424-kocwsyi7 182 53 al al NNP cord-021424-kocwsyi7 182 54 . . NNP cord-021424-kocwsyi7 182 55 , , , cord-021424-kocwsyi7 182 56 2001 2001 CD cord-021424-kocwsyi7 182 57 ; ; : cord-021424-kocwsyi7 182 58 Lund Lund NNP cord-021424-kocwsyi7 182 59 et et NNP cord-021424-kocwsyi7 182 60 al al NNP cord-021424-kocwsyi7 182 61 . . NNP cord-021424-kocwsyi7 182 62 , , , cord-021424-kocwsyi7 182 63 2004 2004 CD cord-021424-kocwsyi7 182 64 ) ) -RRB- cord-021424-kocwsyi7 182 65 . . . cord-021424-kocwsyi7 183 1 These these DT cord-021424-kocwsyi7 183 2 types type NNS cord-021424-kocwsyi7 183 3 of of IN cord-021424-kocwsyi7 183 4 results result NNS cord-021424-kocwsyi7 183 5 raise raise VBP cord-021424-kocwsyi7 183 6 the the DT cord-021424-kocwsyi7 183 7 possibility possibility NN cord-021424-kocwsyi7 183 8 that that IN cord-021424-kocwsyi7 183 9 the the DT cord-021424-kocwsyi7 183 10 diagnosis diagnosis NN cord-021424-kocwsyi7 183 11 of of IN cord-021424-kocwsyi7 183 12 the the DT cord-021424-kocwsyi7 183 13 type type NN cord-021424-kocwsyi7 183 14 of of IN cord-021424-kocwsyi7 183 15 pathogen pathogen NN cord-021424-kocwsyi7 183 16 involved involve VBN cord-021424-kocwsyi7 183 17 in in IN cord-021424-kocwsyi7 183 18 an an DT cord-021424-kocwsyi7 183 19 infection infection NN cord-021424-kocwsyi7 183 20 would would MD cord-021424-kocwsyi7 183 21 be be VB cord-021424-kocwsyi7 183 22 helped help VBN cord-021424-kocwsyi7 183 23 by by IN cord-021424-kocwsyi7 183 24 the the DT cord-021424-kocwsyi7 183 25 development development NN cord-021424-kocwsyi7 183 26 of of IN cord-021424-kocwsyi7 183 27 customized customize VBN cord-021424-kocwsyi7 183 28 microarrays microarray NNS cord-021424-kocwsyi7 183 29 that that WDT cord-021424-kocwsyi7 183 30 could could MD cord-021424-kocwsyi7 183 31 distinguish distinguish VB cord-021424-kocwsyi7 183 32 the the DT cord-021424-kocwsyi7 183 33 gene gene NN cord-021424-kocwsyi7 183 34 expression expression NN cord-021424-kocwsyi7 183 35 profi profi NNP cord-021424-kocwsyi7 183 36 les les NNP cord-021424-kocwsyi7 183 37 elicited elicit VBN cord-021424-kocwsyi7 183 38 by by IN cord-021424-kocwsyi7 183 39 particular particular JJ cord-021424-kocwsyi7 183 40 pathogens pathogen NNS cord-021424-kocwsyi7 183 41 . . . cord-021424-kocwsyi7 184 1 Additionally additionally RB cord-021424-kocwsyi7 184 2 , , , cord-021424-kocwsyi7 184 3 arrays array NNS cord-021424-kocwsyi7 184 4 that that WDT cord-021424-kocwsyi7 184 5 also also RB cord-021424-kocwsyi7 184 6 detect detect VBP cord-021424-kocwsyi7 184 7 RNAs rna NNS cord-021424-kocwsyi7 184 8 produced produce VBN cord-021424-kocwsyi7 184 9 by by IN cord-021424-kocwsyi7 184 10 the the DT cord-021424-kocwsyi7 184 11 pathogen pathogen NN cord-021424-kocwsyi7 184 12 may may MD cord-021424-kocwsyi7 184 13 be be VB cord-021424-kocwsyi7 184 14 even even RB cord-021424-kocwsyi7 184 15 more more JJR cord-021424-kocwsyi7 184 16 signifi signifi NNP cord-021424-kocwsyi7 184 17 ca can MD cord-021424-kocwsyi7 184 18 nt not RB cord-021424-kocwsyi7 184 19 as as IN cord-021424-kocwsyi7 184 20 a a DT cord-021424-kocwsyi7 184 21 diagnostic diagnostic JJ cord-021424-kocwsyi7 184 22 tool tool NN cord-021424-kocwsyi7 184 23 . . . cord-021424-kocwsyi7 185 1 An an DT cord-021424-kocwsyi7 185 2 infecting infect VBG cord-021424-kocwsyi7 185 3 agent agent NN cord-021424-kocwsyi7 185 4 can can MD cord-021424-kocwsyi7 185 5 either either CC cord-021424-kocwsyi7 185 6 be be VB cord-021424-kocwsyi7 185 7 cleared clear VBN cord-021424-kocwsyi7 185 8 from from IN cord-021424-kocwsyi7 185 9 the the DT cord-021424-kocwsyi7 185 10 body body NN cord-021424-kocwsyi7 185 11 by by IN cord-021424-kocwsyi7 185 12 the the DT cord-021424-kocwsyi7 185 13 immune immune JJ cord-021424-kocwsyi7 185 14 system system NN cord-021424-kocwsyi7 185 15 mounting mount VBG cord-021424-kocwsyi7 185 16 an an DT cord-021424-kocwsyi7 185 17 appropriate appropriate JJ cord-021424-kocwsyi7 185 18 response response NN cord-021424-kocwsyi7 185 19 or or CC cord-021424-kocwsyi7 185 20 cause cause VB cord-021424-kocwsyi7 185 21 severe severe JJ cord-021424-kocwsyi7 185 22 or or CC cord-021424-kocwsyi7 185 23 terminal terminal JJ cord-021424-kocwsyi7 185 24 pathology pathology NN cord-021424-kocwsyi7 185 25 . . . cord-021424-kocwsyi7 186 1 The the DT cord-021424-kocwsyi7 186 2 outcome outcome NN cord-021424-kocwsyi7 186 3 depends depend VBZ cord-021424-kocwsyi7 186 4 on on IN cord-021424-kocwsyi7 186 5 a a DT cord-021424-kocwsyi7 186 6 multiplicity multiplicity NN cord-021424-kocwsyi7 186 7 of of IN cord-021424-kocwsyi7 186 8 events event NNS cord-021424-kocwsyi7 186 9 ranging range VBG cord-021424-kocwsyi7 186 10 from from IN cord-021424-kocwsyi7 186 11 the the DT cord-021424-kocwsyi7 186 12 genotype genotype NN cord-021424-kocwsyi7 186 13 of of IN cord-021424-kocwsyi7 186 14 the the DT cord-021424-kocwsyi7 186 15 host host NN cord-021424-kocwsyi7 186 16 , , , cord-021424-kocwsyi7 186 17 that that RB cord-021424-kocwsyi7 186 18 is is RB cord-021424-kocwsyi7 186 19 , , , cord-021424-kocwsyi7 186 20 whether whether IN cord-021424-kocwsyi7 186 21 the the DT cord-021424-kocwsyi7 186 22 host host NN cord-021424-kocwsyi7 186 23 displays display VBZ cord-021424-kocwsyi7 186 24 a a DT cord-021424-kocwsyi7 186 25 resistant resistant JJ cord-021424-kocwsyi7 186 26 or or CC cord-021424-kocwsyi7 186 27 susceptible susceptible JJ cord-021424-kocwsyi7 186 28 phenotype phenotype NN cord-021424-kocwsyi7 186 29 , , , cord-021424-kocwsyi7 186 30 the the DT cord-021424-kocwsyi7 186 31 genotype genotype NN cord-021424-kocwsyi7 186 32 of of IN cord-021424-kocwsyi7 186 33 the the DT cord-021424-kocwsyi7 186 34 infectious infectious JJ cord-021424-kocwsyi7 186 35 agent agent NN cord-021424-kocwsyi7 186 36 , , , cord-021424-kocwsyi7 186 37 that that RB cord-021424-kocwsyi7 186 38 is is RB cord-021424-kocwsyi7 186 39 , , , cord-021424-kocwsyi7 186 40 virulent virulent JJ cord-021424-kocwsyi7 186 41 or or CC cord-021424-kocwsyi7 186 42 non non JJ cord-021424-kocwsyi7 186 43 - - JJ cord-021424-kocwsyi7 186 44 virulent virulent JJ cord-021424-kocwsyi7 186 45 strains strain NNS cord-021424-kocwsyi7 186 46 and and CC cord-021424-kocwsyi7 186 47 many many JJ cord-021424-kocwsyi7 186 48 other other JJ cord-021424-kocwsyi7 187 1 less less JJR cord-021424-kocwsyi7 187 2 defi defi NNP cord-021424-kocwsyi7 187 3 ned ned NNP cord-021424-kocwsyi7 187 4 environmental environmental JJ cord-021424-kocwsyi7 187 5 factors factor NNS cord-021424-kocwsyi7 187 6 . . . cord-021424-kocwsyi7 188 1 Can Can MD cord-021424-kocwsyi7 188 2 genomic genomic JJ cord-021424-kocwsyi7 188 3 approaches approach NNS cord-021424-kocwsyi7 188 4 be be VB cord-021424-kocwsyi7 188 5 used use VBN cord-021424-kocwsyi7 188 6 to to TO cord-021424-kocwsyi7 188 7 determine determine VB cord-021424-kocwsyi7 188 8 the the DT cord-021424-kocwsyi7 188 9 outcome outcome NN cord-021424-kocwsyi7 188 10 of of IN cord-021424-kocwsyi7 188 11 infection infection NN cord-021424-kocwsyi7 188 12 ? ? . cord-021424-kocwsyi7 189 1 Clearly clearly RB cord-021424-kocwsyi7 189 2 , , , cord-021424-kocwsyi7 189 3 as as IN cord-021424-kocwsyi7 189 4 discussed discuss VBN cord-021424-kocwsyi7 189 5 above above RB cord-021424-kocwsyi7 189 6 , , , cord-021424-kocwsyi7 189 7 the the DT cord-021424-kocwsyi7 189 8 technology technology NN cord-021424-kocwsyi7 189 9 is be VBZ cord-021424-kocwsyi7 189 10 developing develop VBG cord-021424-kocwsyi7 189 11 to to IN cord-021424-kocwsyi7 189 12 defi defi NNP cord-021424-kocwsyi7 189 13 ne ne NNP cord-021424-kocwsyi7 190 1 susceptible susceptible JJ cord-021424-kocwsyi7 190 2 and and CC cord-021424-kocwsyi7 190 3 resistant resistant JJ cord-021424-kocwsyi7 190 4 host host NN cord-021424-kocwsyi7 190 5 genotypes genotype NNS cord-021424-kocwsyi7 190 6 especially especially RB cord-021424-kocwsyi7 190 7 in in IN cord-021424-kocwsyi7 190 8 animal animal NN cord-021424-kocwsyi7 190 9 models model NNS cord-021424-kocwsyi7 190 10 of of IN cord-021424-kocwsyi7 190 11 infection infection NN cord-021424-kocwsyi7 190 12 but but CC cord-021424-kocwsyi7 191 1 the the DT cord-021424-kocwsyi7 191 2 ability ability NN cord-021424-kocwsyi7 191 3 to to TO cord-021424-kocwsyi7 191 4 do do VB cord-021424-kocwsyi7 191 5 this this DT cord-021424-kocwsyi7 191 6 routinely routinely RB cord-021424-kocwsyi7 191 7 in in IN cord-021424-kocwsyi7 191 8 human human JJ cord-021424-kocwsyi7 191 9 populations population NNS cord-021424-kocwsyi7 191 10 is be VBZ cord-021424-kocwsyi7 191 11 some some DT cord-021424-kocwsyi7 191 12 way way NN cord-021424-kocwsyi7 191 13 into into IN cord-021424-kocwsyi7 191 14 the the DT cord-021424-kocwsyi7 191 15 future future NN cord-021424-kocwsyi7 191 16 . . . cord-021424-kocwsyi7 192 1 Given give VBN cord-021424-kocwsyi7 192 2 the the DT cord-021424-kocwsyi7 192 3 smaller small JJR cord-021424-kocwsyi7 192 4 genomes genome NNS cord-021424-kocwsyi7 192 5 of of IN cord-021424-kocwsyi7 192 6 pathogenic pathogenic JJ cord-021424-kocwsyi7 192 7 organisms organism NNS cord-021424-kocwsyi7 192 8 , , , cord-021424-kocwsyi7 192 9 defi defi NNP cord-021424-kocwsyi7 192 10 ning ning NNP cord-021424-kocwsyi7 192 11 virulence virulence NN cord-021424-kocwsyi7 192 12 genotypes genotype NNS cord-021424-kocwsyi7 192 13 is be VBZ cord-021424-kocwsyi7 192 14 progressing progress VBG cord-021424-kocwsyi7 192 15 at at IN cord-021424-kocwsyi7 192 16 a a DT cord-021424-kocwsyi7 192 17 faster fast JJR cord-021424-kocwsyi7 192 18 rate rate NN cord-021424-kocwsyi7 192 19 ( ( -LRB- cord-021424-kocwsyi7 192 20 Chan Chan NNP cord-021424-kocwsyi7 192 21 , , , cord-021424-kocwsyi7 192 22 2003 2003 CD cord-021424-kocwsyi7 192 23 ; ; : cord-021424-kocwsyi7 192 24 Dorrell Dorrell NNP cord-021424-kocwsyi7 192 25 et et FW cord-021424-kocwsyi7 192 26 al al NNP cord-021424-kocwsyi7 192 27 . . NNP cord-021424-kocwsyi7 192 28 , , , cord-021424-kocwsyi7 192 29 2005 2005 CD cord-021424-kocwsyi7 192 30 ; ; : cord-021424-kocwsyi7 192 31 Fitzgerald Fitzgerald NNP cord-021424-kocwsyi7 192 32 and and CC cord-021424-kocwsyi7 192 33 Musser Musser NNP cord-021424-kocwsyi7 192 34 , , , cord-021424-kocwsyi7 192 35 2001 2001 CD cord-021424-kocwsyi7 192 36 ; ; : cord-021424-kocwsyi7 192 37 Kato Kato NNP cord-021424-kocwsyi7 192 38 - - HYPH cord-021424-kocwsyi7 192 39 Maeda Maeda NNP cord-021424-kocwsyi7 192 40 et et NNP cord-021424-kocwsyi7 192 41 al al NNP cord-021424-kocwsyi7 192 42 . . NNP cord-021424-kocwsyi7 192 43 , , , cord-021424-kocwsyi7 192 44 2001 2001 CD cord-021424-kocwsyi7 192 45 ; ; : cord-021424-kocwsyi7 192 46 MacFarlane MacFarlane NNP cord-021424-kocwsyi7 192 47 et et NNP cord-021424-kocwsyi7 192 48 al al NNP cord-021424-kocwsyi7 192 49 . . NNP cord-021424-kocwsyi7 192 50 , , , cord-021424-kocwsyi7 192 51 2005 2005 CD cord-021424-kocwsyi7 192 52 ; ; : cord-021424-kocwsyi7 192 53 Schoolnik Schoolnik NNP cord-021424-kocwsyi7 192 54 , , , cord-021424-kocwsyi7 192 55 2002 2002 CD cord-021424-kocwsyi7 192 56 ; ; : cord-021424-kocwsyi7 192 57 Zhang Zhang NNP cord-021424-kocwsyi7 192 58 and and CC cord-021424-kocwsyi7 192 59 Zhang Zhang NNP cord-021424-kocwsyi7 192 60 , , , cord-021424-kocwsyi7 192 61 2006 2006 CD cord-021424-kocwsyi7 192 62 ) ) -RRB- cord-021424-kocwsyi7 192 63 . . . cord-021424-kocwsyi7 193 1 Expression expression NN cord-021424-kocwsyi7 193 2 profi profi NNP cord-021424-kocwsyi7 193 3 ling ling NNP cord-021424-kocwsyi7 193 4 studies study NNS cord-021424-kocwsyi7 193 5 have have VBP cord-021424-kocwsyi7 193 6 been be VBN cord-021424-kocwsyi7 193 7 used use VBN cord-021424-kocwsyi7 193 8 to to TO cord-021424-kocwsyi7 193 9 investigate investigate VB cord-021424-kocwsyi7 193 10 the the DT cord-021424-kocwsyi7 193 11 differences difference NNS cord-021424-kocwsyi7 193 12 in in IN cord-021424-kocwsyi7 193 13 the the DT cord-021424-kocwsyi7 193 14 host host NN cord-021424-kocwsyi7 193 15 response response NN cord-021424-kocwsyi7 193 16 to to IN cord-021424-kocwsyi7 193 17 pathogenic pathogenic JJ cord-021424-kocwsyi7 193 18 and and CC cord-021424-kocwsyi7 193 19 nonpathogenic nonpathogenic JJ cord-021424-kocwsyi7 193 20 strains strain NNS cord-021424-kocwsyi7 193 21 of of IN cord-021424-kocwsyi7 193 22 specifi specifi NNP cord-021424-kocwsyi7 193 23 c c NNP cord-021424-kocwsyi7 193 24 infectious infectious JJ cord-021424-kocwsyi7 193 25 agents agent NNS cord-021424-kocwsyi7 193 26 . . . cord-021424-kocwsyi7 194 1 In in IN cord-021424-kocwsyi7 194 2 one one CD cord-021424-kocwsyi7 194 3 example example NN cord-021424-kocwsyi7 194 4 , , , cord-021424-kocwsyi7 194 5 mice mouse NNS cord-021424-kocwsyi7 194 6 infected infect VBN cord-021424-kocwsyi7 194 7 with with IN cord-021424-kocwsyi7 194 8 a a DT cord-021424-kocwsyi7 194 9 pathogenic pathogenic JJ cord-021424-kocwsyi7 194 10 strain strain NN cord-021424-kocwsyi7 194 11 of of IN cord-021424-kocwsyi7 194 12 pneumonia pneumonia NN cord-021424-kocwsyi7 194 13 virus virus NN cord-021424-kocwsyi7 194 14 upregulated upregulate VBD cord-021424-kocwsyi7 194 15 the the DT cord-021424-kocwsyi7 194 16 expected expect VBN cord-021424-kocwsyi7 194 17 infl infl NNP cord-021424-kocwsyi7 194 18 ammatory ammatory NNP cord-021424-kocwsyi7 194 19 chemokines chemokines NNPS cord-021424-kocwsyi7 194 20 / / SYM cord-021424-kocwsyi7 194 21 cytokine cytokine NN cord-021424-kocwsyi7 194 22 profi profi NNP cord-021424-kocwsyi7 194 23 le le NNP cord-021424-kocwsyi7 194 24 as as RB cord-021424-kocwsyi7 194 25 well well RB cord-021424-kocwsyi7 194 26 as as IN cord-021424-kocwsyi7 194 27 the the DT cord-021424-kocwsyi7 194 28 ISG ISG NNP cord-021424-kocwsyi7 194 29 profi profi NNP cord-021424-kocwsyi7 194 30 le le NNP cord-021424-kocwsyi7 194 31 but but CC cord-021424-kocwsyi7 194 32 an an DT cord-021424-kocwsyi7 194 33 attenuated attenuated JJ cord-021424-kocwsyi7 194 34 strain strain NN cord-021424-kocwsyi7 194 35 of of IN cord-021424-kocwsyi7 194 36 the the DT cord-021424-kocwsyi7 194 37 same same JJ cord-021424-kocwsyi7 194 38 virus virus NN cord-021424-kocwsyi7 195 1 could could MD cord-021424-kocwsyi7 195 2 not not RB cord-021424-kocwsyi7 195 3 , , , cord-021424-kocwsyi7 195 4 although although IN cord-021424-kocwsyi7 195 5 the the DT cord-021424-kocwsyi7 195 6 virus virus NN cord-021424-kocwsyi7 195 7 replicated replicate VBN cord-021424-kocwsyi7 195 8 in in IN cord-021424-kocwsyi7 195 9 the the DT cord-021424-kocwsyi7 195 10 lungs lung NNS cord-021424-kocwsyi7 195 11 of of IN cord-021424-kocwsyi7 195 12 these these DT cord-021424-kocwsyi7 195 13 mice mouse NNS cord-021424-kocwsyi7 195 14 to to IN cord-021424-kocwsyi7 195 15 the the DT cord-021424-kocwsyi7 195 16 same same JJ cord-021424-kocwsyi7 195 17 degree degree NN cord-021424-kocwsyi7 195 18 ( ( -LRB- cord-021424-kocwsyi7 195 19 Domachowske Domachowske NNP cord-021424-kocwsyi7 195 20 et et FW cord-021424-kocwsyi7 195 21 al al NNP cord-021424-kocwsyi7 195 22 . . NNP cord-021424-kocwsyi7 195 23 , , , cord-021424-kocwsyi7 195 24 2001 2001 CD cord-021424-kocwsyi7 195 25 ) ) -RRB- cord-021424-kocwsyi7 195 26 . . . cord-021424-kocwsyi7 196 1 Temporal temporal JJ cord-021424-kocwsyi7 196 2 profi profi NNP cord-021424-kocwsyi7 196 3 ling ling NNP cord-021424-kocwsyi7 196 4 of of IN cord-021424-kocwsyi7 196 5 the the DT cord-021424-kocwsyi7 196 6 infection infection NN cord-021424-kocwsyi7 196 7 process process NN cord-021424-kocwsyi7 196 8 in in IN cord-021424-kocwsyi7 196 9 animals animal NNS cord-021424-kocwsyi7 196 10 will will MD cord-021424-kocwsyi7 196 11 also also RB cord-021424-kocwsyi7 196 12 help help VB cord-021424-kocwsyi7 196 13 to to TO cord-021424-kocwsyi7 196 14 defi defi NNP cord-021424-kocwsyi7 196 15 ne ne NNP cord-021424-kocwsyi7 196 16 the the DT cord-021424-kocwsyi7 196 17 expression expression NN cord-021424-kocwsyi7 196 18 signatures signature NNS cord-021424-kocwsyi7 196 19 associated associate VBN cord-021424-kocwsyi7 196 20 with with IN cord-021424-kocwsyi7 196 21 the the DT cord-021424-kocwsyi7 196 22 ability ability NN cord-021424-kocwsyi7 196 23 of of IN cord-021424-kocwsyi7 196 24 the the DT cord-021424-kocwsyi7 196 25 host host NN cord-021424-kocwsyi7 196 26 to to TO cord-021424-kocwsyi7 196 27 clear clear VB cord-021424-kocwsyi7 196 28 specifi specifi NNP cord-021424-kocwsyi7 196 29 c c NN cord-021424-kocwsyi7 196 30 pathogens pathogen NNS cord-021424-kocwsyi7 196 31 . . . cord-021424-kocwsyi7 197 1 While while IN cord-021424-kocwsyi7 197 2 considerable considerable JJ cord-021424-kocwsyi7 197 3 information information NN cord-021424-kocwsyi7 197 4 and and CC cord-021424-kocwsyi7 197 5 progress progress NN cord-021424-kocwsyi7 197 6 is be VBZ cord-021424-kocwsyi7 197 7 being be VBG cord-021424-kocwsyi7 197 8 made make VBN cord-021424-kocwsyi7 197 9 with with IN cord-021424-kocwsyi7 197 10 the the DT cord-021424-kocwsyi7 197 11 approaches approach NNS cord-021424-kocwsyi7 197 12 described describe VBN cord-021424-kocwsyi7 197 13 above above RB cord-021424-kocwsyi7 197 14 , , , cord-021424-kocwsyi7 197 15 there there EX cord-021424-kocwsyi7 197 16 is be VBZ cord-021424-kocwsyi7 197 17 now now RB cord-021424-kocwsyi7 197 18 much much JJ cord-021424-kocwsyi7 197 19 interest interest NN cord-021424-kocwsyi7 197 20 in in IN cord-021424-kocwsyi7 197 21 combining combine VBG cord-021424-kocwsyi7 197 22 both both CC cord-021424-kocwsyi7 197 23 a a DT cord-021424-kocwsyi7 197 24 genetic genetic JJ cord-021424-kocwsyi7 197 25 screening screening NN cord-021424-kocwsyi7 197 26 approach approach NN cord-021424-kocwsyi7 197 27 with with IN cord-021424-kocwsyi7 197 28 an an DT cord-021424-kocwsyi7 197 29 expression expression NN cord-021424-kocwsyi7 197 30 profi profi NNP cord-021424-kocwsyi7 197 31 ling ling NNP cord-021424-kocwsyi7 197 32 approach approach NN cord-021424-kocwsyi7 197 33 in in IN cord-021424-kocwsyi7 197 34 a a DT cord-021424-kocwsyi7 197 35 new new JJ cord-021424-kocwsyi7 197 36 area area NN cord-021424-kocwsyi7 197 37 of of IN cord-021424-kocwsyi7 197 38 investigation investigation NN cord-021424-kocwsyi7 197 39 being be VBG cord-021424-kocwsyi7 197 40 dubbed dub VBN cord-021424-kocwsyi7 197 41 " " `` cord-021424-kocwsyi7 197 42 genetical genetical JJ cord-021424-kocwsyi7 197 43 genomics genomic NNS cord-021424-kocwsyi7 197 44 " " '' cord-021424-kocwsyi7 197 45 ( ( -LRB- cord-021424-kocwsyi7 197 46 reviewed review VBN cord-021424-kocwsyi7 197 47 in in IN cord-021424-kocwsyi7 197 48 de de NNP cord-021424-kocwsyi7 197 49 Koning Koning NNP cord-021424-kocwsyi7 197 50 et et FW cord-021424-kocwsyi7 197 51 al al NNP cord-021424-kocwsyi7 197 52 . . . cord-021424-kocwsyi7 198 1 , , , cord-021424-kocwsyi7 198 2 2005 2005 CD cord-021424-kocwsyi7 198 3 ; ; : cord-021424-kocwsyi7 198 4 Schadt Schadt NNP cord-021424-kocwsyi7 198 5 et et NNP cord-021424-kocwsyi7 198 6 al al NNP cord-021424-kocwsyi7 198 7 . . NNP cord-021424-kocwsyi7 198 8 , , , cord-021424-kocwsyi7 198 9 2003 2003 CD cord-021424-kocwsyi7 198 10 ] ] -RRB- cord-021424-kocwsyi7 198 11 ) ) -RRB- cord-021424-kocwsyi7 198 12 . . . cord-021424-kocwsyi7 199 1 The the DT cord-021424-kocwsyi7 199 2 rationale rationale NN cord-021424-kocwsyi7 199 3 behind behind IN cord-021424-kocwsyi7 199 4 this this DT cord-021424-kocwsyi7 199 5 combination combination NN cord-021424-kocwsyi7 199 6 is be VBZ cord-021424-kocwsyi7 199 7 twofold twofold JJ cord-021424-kocwsyi7 199 8 : : : cord-021424-kocwsyi7 199 9 fi fi NNP cord-021424-kocwsyi7 199 10 rst rst NNP cord-021424-kocwsyi7 199 11 , , , cord-021424-kocwsyi7 199 12 expression expression NN cord-021424-kocwsyi7 199 13 profi profi NNP cord-021424-kocwsyi7 199 14 ling ling NNP cord-021424-kocwsyi7 199 15 data datum NNS cord-021424-kocwsyi7 199 16 can can MD cord-021424-kocwsyi7 199 17 be be VB cord-021424-kocwsyi7 199 18 used use VBN cord-021424-kocwsyi7 199 19 to to TO cord-021424-kocwsyi7 199 20 identify identify VB cord-021424-kocwsyi7 199 21 those those DT cord-021424-kocwsyi7 199 22 genes gene NNS cord-021424-kocwsyi7 199 23 in in IN cord-021424-kocwsyi7 199 24 a a DT cord-021424-kocwsyi7 199 25 chromosomal chromosomal JJ cord-021424-kocwsyi7 199 26 region region NN cord-021424-kocwsyi7 199 27 previously previously RB cord-021424-kocwsyi7 199 28 identifi identifi NNP cord-021424-kocwsyi7 199 29 ed ed NN cord-021424-kocwsyi7 199 30 from from IN cord-021424-kocwsyi7 199 31 genetic genetic JJ cord-021424-kocwsyi7 199 32 approaches approach NNS cord-021424-kocwsyi7 199 33 , , , cord-021424-kocwsyi7 199 34 whose whose WP$ cord-021424-kocwsyi7 199 35 expression expression NN cord-021424-kocwsyi7 199 36 is be VBZ cord-021424-kocwsyi7 199 37 altered alter VBN cord-021424-kocwsyi7 199 38 between between IN cord-021424-kocwsyi7 199 39 two two CD cord-021424-kocwsyi7 199 40 different different JJ cord-021424-kocwsyi7 199 41 genotypes genotype NNS cord-021424-kocwsyi7 199 42 . . . cord-021424-kocwsyi7 200 1 These these DT cord-021424-kocwsyi7 200 2 genes gene NNS cord-021424-kocwsyi7 200 3 then then RB cord-021424-kocwsyi7 200 4 immediately immediately RB cord-021424-kocwsyi7 200 5 become become VBP cord-021424-kocwsyi7 200 6 strong strong JJ cord-021424-kocwsyi7 200 7 candidates candidate NNS cord-021424-kocwsyi7 200 8 for for IN cord-021424-kocwsyi7 200 9 a a DT cord-021424-kocwsyi7 200 10 susceptibility susceptibility NN cord-021424-kocwsyi7 200 11 gene gene NN cord-021424-kocwsyi7 200 12 at at IN cord-021424-kocwsyi7 200 13 that that DT cord-021424-kocwsyi7 200 14 genetic genetic JJ cord-021424-kocwsyi7 200 15 locus locus NN cord-021424-kocwsyi7 200 16 . . . cord-021424-kocwsyi7 201 1 In in IN cord-021424-kocwsyi7 201 2 this this DT cord-021424-kocwsyi7 201 3 way way NN cord-021424-kocwsyi7 201 4 , , , cord-021424-kocwsyi7 201 5 mutations mutation NNS cord-021424-kocwsyi7 201 6 that that WDT cord-021424-kocwsyi7 201 7 affect affect VBP cord-021424-kocwsyi7 201 8 the the DT cord-021424-kocwsyi7 201 9 expression expression NN cord-021424-kocwsyi7 201 10 but but CC cord-021424-kocwsyi7 201 11 not not RB cord-021424-kocwsyi7 201 12 the the DT cord-021424-kocwsyi7 201 13 function function NN cord-021424-kocwsyi7 201 14 of of IN cord-021424-kocwsyi7 201 15 a a DT cord-021424-kocwsyi7 201 16 protein protein NN cord-021424-kocwsyi7 201 17 can can MD cord-021424-kocwsyi7 201 18 also also RB cord-021424-kocwsyi7 201 19 be be VB cord-021424-kocwsyi7 201 20 identifi identifi VBN cord-021424-kocwsyi7 201 21 ed ed NNP cord-021424-kocwsyi7 201 22 . . . cord-021424-kocwsyi7 202 1 Second second JJ cord-021424-kocwsyi7 202 2 , , , cord-021424-kocwsyi7 202 3 expression expression NN cord-021424-kocwsyi7 202 4 profi profi NNP cord-021424-kocwsyi7 202 5 ling ling NNP cord-021424-kocwsyi7 202 6 combined combine VBN cord-021424-kocwsyi7 202 7 with with IN cord-021424-kocwsyi7 202 8 genotyping genotyping NN cord-021424-kocwsyi7 202 9 can can MD cord-021424-kocwsyi7 202 10 identify identify VB cord-021424-kocwsyi7 202 11 functional functional JJ cord-021424-kocwsyi7 202 12 pathways pathway NNS cord-021424-kocwsyi7 202 13 that that WDT cord-021424-kocwsyi7 202 14 can can MD cord-021424-kocwsyi7 202 15 be be VB cord-021424-kocwsyi7 202 16 affected affect VBN cord-021424-kocwsyi7 202 17 by by IN cord-021424-kocwsyi7 202 18 a a DT cord-021424-kocwsyi7 202 19 single single JJ cord-021424-kocwsyi7 202 20 mutation mutation NN cord-021424-kocwsyi7 202 21 . . . cord-021424-kocwsyi7 203 1 For for IN cord-021424-kocwsyi7 203 2 example example NN cord-021424-kocwsyi7 203 3 , , , cord-021424-kocwsyi7 203 4 if if IN cord-021424-kocwsyi7 203 5 a a DT cord-021424-kocwsyi7 203 6 mutation mutation NN cord-021424-kocwsyi7 203 7 affects affect VBZ cord-021424-kocwsyi7 203 8 a a DT cord-021424-kocwsyi7 203 9 transcription transcription NN cord-021424-kocwsyi7 203 10 factor factor NN cord-021424-kocwsyi7 203 11 that that WDT cord-021424-kocwsyi7 203 12 controls control VBZ cord-021424-kocwsyi7 203 13 expression expression NN cord-021424-kocwsyi7 203 14 of of IN cord-021424-kocwsyi7 203 15 a a DT cord-021424-kocwsyi7 203 16 group group NN cord-021424-kocwsyi7 203 17 of of IN cord-021424-kocwsyi7 203 18 functionally functionally RB cord-021424-kocwsyi7 203 19 related relate VBN cord-021424-kocwsyi7 203 20 genes gene NNS cord-021424-kocwsyi7 203 21 then then RB cord-021424-kocwsyi7 203 22 not not RB cord-021424-kocwsyi7 203 23 only only RB cord-021424-kocwsyi7 203 24 the the DT cord-021424-kocwsyi7 203 25 transcription transcription NN cord-021424-kocwsyi7 203 26 factor factor NN cord-021424-kocwsyi7 203 27 but but CC cord-021424-kocwsyi7 203 28 the the DT cord-021424-kocwsyi7 203 29 entire entire JJ cord-021424-kocwsyi7 203 30 pathway pathway NN cord-021424-kocwsyi7 203 31 will will MD cord-021424-kocwsyi7 203 32 be be VB cord-021424-kocwsyi7 203 33 identifi identifi NNP cord-021424-kocwsyi7 203 34 ed ed NNP cord-021424-kocwsyi7 203 35 opening opening NN cord-021424-kocwsyi7 203 36 up up RP cord-021424-kocwsyi7 203 37 better well JJR cord-021424-kocwsyi7 203 38 opportunities opportunity NNS cord-021424-kocwsyi7 203 39 to to TO cord-021424-kocwsyi7 203 40 design design VB cord-021424-kocwsyi7 203 41 new new JJ cord-021424-kocwsyi7 203 42 therapeutics therapeutic NNS cord-021424-kocwsyi7 203 43 . . . cord-021424-kocwsyi7 204 1 In in IN cord-021424-kocwsyi7 204 2 a a DT cord-021424-kocwsyi7 204 3 prelude prelude NN cord-021424-kocwsyi7 204 4 to to IN cord-021424-kocwsyi7 204 5 these these DT cord-021424-kocwsyi7 204 6 types type NNS cord-021424-kocwsyi7 204 7 of of IN cord-021424-kocwsyi7 204 8 approaches approach NNS cord-021424-kocwsyi7 204 9 , , , cord-021424-kocwsyi7 204 10 Hume Hume NNP cord-021424-kocwsyi7 204 11 and and CC cord-021424-kocwsyi7 204 12 colleagues colleague NNS cord-021424-kocwsyi7 204 13 ( ( -LRB- cord-021424-kocwsyi7 204 14 Wells Wells NNP cord-021424-kocwsyi7 204 15 et et NNP cord-021424-kocwsyi7 204 16 al al NNP cord-021424-kocwsyi7 204 17 . . NNP cord-021424-kocwsyi7 204 18 , , , cord-021424-kocwsyi7 204 19 2003 2003 CD cord-021424-kocwsyi7 204 20 ) ) -RRB- cord-021424-kocwsyi7 204 21 carried carry VBD cord-021424-kocwsyi7 204 22 out out RP cord-021424-kocwsyi7 204 23 expression expression NN cord-021424-kocwsyi7 205 1 profi profi NNP cord-021424-kocwsyi7 205 2 ling ling NNP cord-021424-kocwsyi7 205 3 studies study NNS cord-021424-kocwsyi7 205 4 on on IN cord-021424-kocwsyi7 205 5 LPS LPS NNP cord-021424-kocwsyi7 205 6 - - HYPH cord-021424-kocwsyi7 205 7 stimulated stimulate VBN cord-021424-kocwsyi7 205 8 macrophages macrophage NNS cord-021424-kocwsyi7 205 9 from from IN cord-021424-kocwsyi7 205 10 various various JJ cord-021424-kocwsyi7 205 11 mouse mouse NN cord-021424-kocwsyi7 205 12 strains strain NNS cord-021424-kocwsyi7 205 13 that that WDT cord-021424-kocwsyi7 205 14 show show VBP cord-021424-kocwsyi7 205 15 differential differential JJ cord-021424-kocwsyi7 205 16 response response NN cord-021424-kocwsyi7 205 17 to to IN cord-021424-kocwsyi7 205 18 infection infection NN cord-021424-kocwsyi7 205 19 . . . cord-021424-kocwsyi7 206 1 These these DT cord-021424-kocwsyi7 206 2 studies study NNS cord-021424-kocwsyi7 206 3 showed show VBD cord-021424-kocwsyi7 206 4 that that IN cord-021424-kocwsyi7 206 5 while while IN cord-021424-kocwsyi7 206 6 there there EX cord-021424-kocwsyi7 206 7 was be VBD cord-021424-kocwsyi7 206 8 a a DT cord-021424-kocwsyi7 206 9 common common JJ cord-021424-kocwsyi7 206 10 core core NN cord-021424-kocwsyi7 206 11 response response NN cord-021424-kocwsyi7 206 12 to to IN cord-021424-kocwsyi7 206 13 TLR4 TLR4 NNP cord-021424-kocwsyi7 206 14 activation activation NN cord-021424-kocwsyi7 206 15 , , , cord-021424-kocwsyi7 206 16 each each DT cord-021424-kocwsyi7 206 17 strain strain NN cord-021424-kocwsyi7 206 18 of of IN cord-021424-kocwsyi7 206 19 mice mouse NNS cord-021424-kocwsyi7 206 20 showed show VBD cord-021424-kocwsyi7 206 21 a a DT cord-021424-kocwsyi7 206 22 unique unique JJ cord-021424-kocwsyi7 206 23 gene gene NN cord-021424-kocwsyi7 206 24 expression expression NN cord-021424-kocwsyi7 206 25 program program NN cord-021424-kocwsyi7 206 26 implicating implicate VBG cord-021424-kocwsyi7 206 27 many many JJ cord-021424-kocwsyi7 206 28 different different JJ cord-021424-kocwsyi7 206 29 genetic genetic JJ cord-021424-kocwsyi7 206 30 loci locus NNS cord-021424-kocwsyi7 206 31 in in IN cord-021424-kocwsyi7 206 32 this this DT cord-021424-kocwsyi7 206 33 variable variable JJ cord-021424-kocwsyi7 206 34 response response NN cord-021424-kocwsyi7 206 35 . . . cord-021424-kocwsyi7 207 1 Mapping map VBG cord-021424-kocwsyi7 207 2 the the DT cord-021424-kocwsyi7 207 3 genetic genetic JJ cord-021424-kocwsyi7 207 4 loci locus NNS cord-021424-kocwsyi7 207 5 responsible responsible JJ cord-021424-kocwsyi7 207 6 for for IN cord-021424-kocwsyi7 207 7 these these DT cord-021424-kocwsyi7 207 8 different different JJ cord-021424-kocwsyi7 207 9 transcriptional transcriptional JJ cord-021424-kocwsyi7 207 10 responses response NNS cord-021424-kocwsyi7 207 11 will will MD cord-021424-kocwsyi7 207 12 help help VB cord-021424-kocwsyi7 207 13 to to TO cord-021424-kocwsyi7 207 14 shed shed VB cord-021424-kocwsyi7 207 15 light light NN cord-021424-kocwsyi7 207 16 on on IN cord-021424-kocwsyi7 207 17 genetic genetic JJ cord-021424-kocwsyi7 207 18 loci locus NNS cord-021424-kocwsyi7 207 19 that that WDT cord-021424-kocwsyi7 207 20 may may MD cord-021424-kocwsyi7 207 21 play play VB cord-021424-kocwsyi7 207 22 a a DT cord-021424-kocwsyi7 207 23 role role NN cord-021424-kocwsyi7 207 24 in in IN cord-021424-kocwsyi7 207 25 human human JJ cord-021424-kocwsyi7 207 26 susceptibility susceptibility NN cord-021424-kocwsyi7 207 27 to to IN cord-021424-kocwsyi7 207 28 infection infection NN cord-021424-kocwsyi7 207 29 . . . cord-021424-kocwsyi7 208 1 These these DT cord-021424-kocwsyi7 208 2 type type NN cord-021424-kocwsyi7 208 3 of of IN cord-021424-kocwsyi7 208 4 approaches approach NNS cord-021424-kocwsyi7 208 5 move move VBP cord-021424-kocwsyi7 208 6 into into IN cord-021424-kocwsyi7 208 7 the the DT cord-021424-kocwsyi7 208 8 realms realm NNS cord-021424-kocwsyi7 208 9 of of IN cord-021424-kocwsyi7 208 10 " " `` cord-021424-kocwsyi7 208 11 systems system NNS cord-021424-kocwsyi7 208 12 biology biology NN cord-021424-kocwsyi7 208 13 " " '' cord-021424-kocwsyi7 208 14 which which WDT cord-021424-kocwsyi7 208 15 is be VBZ cord-021424-kocwsyi7 208 16 the the DT cord-021424-kocwsyi7 208 17 study study NN cord-021424-kocwsyi7 208 18 of of IN cord-021424-kocwsyi7 208 19 an an DT cord-021424-kocwsyi7 208 20 organism organism NN cord-021424-kocwsyi7 208 21 , , , cord-021424-kocwsyi7 208 22 viewed view VBN cord-021424-kocwsyi7 208 23 as as IN cord-021424-kocwsyi7 208 24 an an DT cord-021424-kocwsyi7 208 25 integrated integrated JJ cord-021424-kocwsyi7 208 26 and and CC cord-021424-kocwsyi7 208 27 interacting interact VBG cord-021424-kocwsyi7 208 28 network network NN cord-021424-kocwsyi7 208 29 of of IN cord-021424-kocwsyi7 208 30 genes gene NNS cord-021424-kocwsyi7 208 31 , , , cord-021424-kocwsyi7 208 32 proteins protein NNS cord-021424-kocwsyi7 208 33 and and CC cord-021424-kocwsyi7 208 34 biochemical biochemical JJ cord-021424-kocwsyi7 208 35 reactions reaction NNS cord-021424-kocwsyi7 208 36 , , , cord-021424-kocwsyi7 208 37 focusing focus VBG cord-021424-kocwsyi7 208 38 on on IN cord-021424-kocwsyi7 208 39 all all PDT cord-021424-kocwsyi7 208 40 the the DT cord-021424-kocwsyi7 208 41 components component NNS cord-021424-kocwsyi7 208 42 and and CC cord-021424-kocwsyi7 208 43 the the DT cord-021424-kocwsyi7 208 44 interactions interaction NNS cord-021424-kocwsyi7 208 45 among among IN cord-021424-kocwsyi7 208 46 them -PRON- PRP cord-021424-kocwsyi7 208 47 , , , cord-021424-kocwsyi7 208 48 as as IN cord-021424-kocwsyi7 208 49 part part NN cord-021424-kocwsyi7 208 50 of of IN cord-021424-kocwsyi7 208 51 one one CD cord-021424-kocwsyi7 208 52 system system NN cord-021424-kocwsyi7 208 53 . . . cord-021424-kocwsyi7 209 1 Given give VBN cord-021424-kocwsyi7 209 2 the the DT cord-021424-kocwsyi7 209 3 complexity complexity NN cord-021424-kocwsyi7 209 4 of of IN cord-021424-kocwsyi7 209 5 the the DT cord-021424-kocwsyi7 209 6 immune immune JJ cord-021424-kocwsyi7 209 7 response response NN cord-021424-kocwsyi7 209 8 to to IN cord-021424-kocwsyi7 209 9 infection infection NN cord-021424-kocwsyi7 209 10 , , , cord-021424-kocwsyi7 209 11 ultimately ultimately RB cord-021424-kocwsyi7 209 12 this this DT cord-021424-kocwsyi7 209 13 type type NN cord-021424-kocwsyi7 209 14 of of IN cord-021424-kocwsyi7 209 15 approach approach NN cord-021424-kocwsyi7 209 16 may may MD cord-021424-kocwsyi7 209 17 provide provide VB cord-021424-kocwsyi7 209 18 more more JJR cord-021424-kocwsyi7 209 19 answers answer NNS cord-021424-kocwsyi7 209 20 . . . cord-021424-kocwsyi7 210 1 Although although IN cord-021424-kocwsyi7 210 2 genomic genomic JJ cord-021424-kocwsyi7 210 3 approaches approach NNS cord-021424-kocwsyi7 210 4 to to IN cord-021424-kocwsyi7 210 5 understanding understand VBG cord-021424-kocwsyi7 210 6 the the DT cord-021424-kocwsyi7 210 7 host host NN cord-021424-kocwsyi7 210 8 response response NN cord-021424-kocwsyi7 210 9 to to IN cord-021424-kocwsyi7 210 10 infectious infectious JJ cord-021424-kocwsyi7 210 11 disease disease NN cord-021424-kocwsyi7 210 12 are be VBP cord-021424-kocwsyi7 210 13 still still RB cord-021424-kocwsyi7 210 14 very very RB cord-021424-kocwsyi7 210 15 much much RB cord-021424-kocwsyi7 210 16 at at IN cord-021424-kocwsyi7 210 17 the the DT cord-021424-kocwsyi7 210 18 developmental developmental JJ cord-021424-kocwsyi7 210 19 stage stage NN cord-021424-kocwsyi7 210 20 , , , cord-021424-kocwsyi7 210 21 it -PRON- PRP cord-021424-kocwsyi7 210 22 is be VBZ cord-021424-kocwsyi7 210 23 likely likely JJ cord-021424-kocwsyi7 210 24 that that IN cord-021424-kocwsyi7 210 25 such such JJ cord-021424-kocwsyi7 210 26 approaches approach NNS cord-021424-kocwsyi7 210 27 will will MD cord-021424-kocwsyi7 210 28 be be VB cord-021424-kocwsyi7 210 29 applied apply VBN cord-021424-kocwsyi7 210 30 to to IN cord-021424-kocwsyi7 210 31 diagnosis diagnosis NN cord-021424-kocwsyi7 210 32 in in IN cord-021424-kocwsyi7 210 33 the the DT cord-021424-kocwsyi7 210 34 near near JJ cord-021424-kocwsyi7 210 35 future future NN cord-021424-kocwsyi7 210 36 . . . cord-021424-kocwsyi7 211 1 In in IN cord-021424-kocwsyi7 211 2 fact fact NN cord-021424-kocwsyi7 211 3 there there EX cord-021424-kocwsyi7 211 4 are be VBP cord-021424-kocwsyi7 211 5 already already RB cord-021424-kocwsyi7 211 6 some some DT cord-021424-kocwsyi7 211 7 examples example NNS cord-021424-kocwsyi7 211 8 of of IN cord-021424-kocwsyi7 211 9 the the DT cord-021424-kocwsyi7 211 10 application application NN cord-021424-kocwsyi7 211 11 of of IN cord-021424-kocwsyi7 211 12 these these DT cord-021424-kocwsyi7 211 13 approaches approach NNS cord-021424-kocwsyi7 211 14 . . . cord-021424-kocwsyi7 212 1 A a DT cord-021424-kocwsyi7 212 2 number number NN cord-021424-kocwsyi7 212 3 of of IN cord-021424-kocwsyi7 212 4 studies study NNS cord-021424-kocwsyi7 212 5 have have VBP cord-021424-kocwsyi7 212 6 been be VBN cord-021424-kocwsyi7 212 7 described describe VBN cord-021424-kocwsyi7 212 8 using use VBG cord-021424-kocwsyi7 212 9 oligonucleotide oligonucleotide RB cord-021424-kocwsyi7 212 10 - - HYPH cord-021424-kocwsyi7 212 11 based base VBN cord-021424-kocwsyi7 212 12 arrays array NNS cord-021424-kocwsyi7 212 13 for for IN cord-021424-kocwsyi7 212 14 the the DT cord-021424-kocwsyi7 212 15 detection detection NN cord-021424-kocwsyi7 212 16 of of IN cord-021424-kocwsyi7 212 17 multiple multiple JJ cord-021424-kocwsyi7 212 18 pathogens pathogen NNS cord-021424-kocwsyi7 212 19 in in IN cord-021424-kocwsyi7 212 20 a a DT cord-021424-kocwsyi7 212 21 single single JJ cord-021424-kocwsyi7 212 22 experiment experiment NN cord-021424-kocwsyi7 212 23 ( ( -LRB- cord-021424-kocwsyi7 212 24 Campbell Campbell NNP cord-021424-kocwsyi7 212 25 and and CC cord-021424-kocwsyi7 212 26 Ghazal Ghazal NNP cord-021424-kocwsyi7 212 27 , , , cord-021424-kocwsyi7 212 28 2004 2004 CD cord-021424-kocwsyi7 212 29 ; ; : cord-021424-kocwsyi7 212 30 Dietel Dietel NNP cord-021424-kocwsyi7 212 31 and and CC cord-021424-kocwsyi7 212 32 Sers Sers NNPS cord-021424-kocwsyi7 212 33 , , , cord-021424-kocwsyi7 212 34 2006 2006 CD cord-021424-kocwsyi7 212 35 ; ; : cord-021424-kocwsyi7 212 36 Hervas Hervas NNP cord-021424-kocwsyi7 212 37 , , , cord-021424-kocwsyi7 212 38 2004 2004 CD cord-021424-kocwsyi7 212 39 ; ; : cord-021424-kocwsyi7 212 40 Kostrzynska Kostrzynska NNP cord-021424-kocwsyi7 212 41 and and CC cord-021424-kocwsyi7 212 42 Bachand Bachand NNP cord-021424-kocwsyi7 212 43 , , , cord-021424-kocwsyi7 212 44 2006 2006 CD cord-021424-kocwsyi7 212 45 ; ; : cord-021424-kocwsyi7 212 46 Pompe Pompe NNP cord-021424-kocwsyi7 212 47 et et NNP cord-021424-kocwsyi7 212 48 al al NNP cord-021424-kocwsyi7 212 49 . . NNP cord-021424-kocwsyi7 212 50 , , , cord-021424-kocwsyi7 212 51 2005 2005 CD cord-021424-kocwsyi7 212 52 ) ) -RRB- cord-021424-kocwsyi7 212 53 . . . cord-021424-kocwsyi7 213 1 Recent recent JJ cord-021424-kocwsyi7 213 2 studies study NNS cord-021424-kocwsyi7 213 3 have have VBP cord-021424-kocwsyi7 213 4 investigated investigate VBN cord-021424-kocwsyi7 213 5 the the DT cord-021424-kocwsyi7 213 6 use use NN cord-021424-kocwsyi7 213 7 of of IN cord-021424-kocwsyi7 213 8 expression expression NN cord-021424-kocwsyi7 213 9 profi profi NNP cord-021424-kocwsyi7 213 10 ling ling NNP cord-021424-kocwsyi7 213 11 of of IN cord-021424-kocwsyi7 213 12 whole whole JJ cord-021424-kocwsyi7 213 13 blood blood NN cord-021424-kocwsyi7 213 14 to to TO cord-021424-kocwsyi7 213 15 determine determine VB cord-021424-kocwsyi7 213 16 human human JJ cord-021424-kocwsyi7 213 17 subjects subject NNS cord-021424-kocwsyi7 213 18 at at IN cord-021424-kocwsyi7 213 19 risk risk NN cord-021424-kocwsyi7 213 20 of of IN cord-021424-kocwsyi7 213 21 recurrent recurrent JJ cord-021424-kocwsyi7 213 22 tuberculosis tuberculosis NN cord-021424-kocwsyi7 214 1 ( ( -LRB- cord-021424-kocwsyi7 214 2 Mistry Mistry NNP cord-021424-kocwsyi7 214 3 et et NNP cord-021424-kocwsyi7 214 4 al al NNP cord-021424-kocwsyi7 214 5 . . NNP cord-021424-kocwsyi7 214 6 , , , cord-021424-kocwsyi7 214 7 2007 2007 CD cord-021424-kocwsyi7 214 8 ) ) -RRB- cord-021424-kocwsyi7 214 9 and and CC cord-021424-kocwsyi7 214 10 to to TO cord-021424-kocwsyi7 214 11 identify identify VB cord-021424-kocwsyi7 214 12 high high JJ cord-021424-kocwsyi7 214 13 and and CC cord-021424-kocwsyi7 214 14 low low JJ cord-021424-kocwsyi7 214 15 responders responder NNS cord-021424-kocwsyi7 214 16 to to IN cord-021424-kocwsyi7 214 17 lipopolysaccharide lipopolysaccharide NN cord-021424-kocwsyi7 214 18 ( ( -LRB- cord-021424-kocwsyi7 214 19 Wurfel Wurfel NNP cord-021424-kocwsyi7 214 20 et et NNP cord-021424-kocwsyi7 214 21 al al NNP cord-021424-kocwsyi7 214 22 . . NNP cord-021424-kocwsyi7 214 23 , , , cord-021424-kocwsyi7 214 24 2005 2005 CD cord-021424-kocwsyi7 214 25 ) ) -RRB- cord-021424-kocwsyi7 214 26 . . . cord-021424-kocwsyi7 215 1 A a DT cord-021424-kocwsyi7 215 2 study study NN cord-021424-kocwsyi7 215 3 in in IN cord-021424-kocwsyi7 215 4 macaques macaque NNS cord-021424-kocwsyi7 215 5 has have VBZ cord-021424-kocwsyi7 215 6 used use VBN cord-021424-kocwsyi7 215 7 whole whole JJ cord-021424-kocwsyi7 215 8 blood blood NN cord-021424-kocwsyi7 215 9 expression expression NN cord-021424-kocwsyi7 215 10 profi profi NNP cord-021424-kocwsyi7 215 11 ling ling NNP cord-021424-kocwsyi7 215 12 to to TO cord-021424-kocwsyi7 215 13 examine examine VB cord-021424-kocwsyi7 215 14 molecular molecular JJ cord-021424-kocwsyi7 215 15 signatures signature NNS cord-021424-kocwsyi7 215 16 of of IN cord-021424-kocwsyi7 215 17 infl infl NN cord-021424-kocwsyi7 215 18 uenza uenza NNP cord-021424-kocwsyi7 215 19 infection infection NN cord-021424-kocwsyi7 216 1 ( ( -LRB- cord-021424-kocwsyi7 216 2 Baas Baas NNP cord-021424-kocwsyi7 216 3 et et NNP cord-021424-kocwsyi7 216 4 al al NNP cord-021424-kocwsyi7 216 5 . . NNP cord-021424-kocwsyi7 216 6 , , , cord-021424-kocwsyi7 216 7 2006 2006 CD cord-021424-kocwsyi7 216 8 ) ) -RRB- cord-021424-kocwsyi7 216 9 . . . cord-021424-kocwsyi7 217 1 There there EX cord-021424-kocwsyi7 217 2 are be VBP cord-021424-kocwsyi7 217 3 many many JJ cord-021424-kocwsyi7 217 4 efforts effort NNS cord-021424-kocwsyi7 217 5 currently currently RB cord-021424-kocwsyi7 217 6 to to TO cord-021424-kocwsyi7 217 7 optimize optimize VB cord-021424-kocwsyi7 217 8 expression expression NN cord-021424-kocwsyi7 217 9 profi profi NNP cord-021424-kocwsyi7 217 10 ling ling NNP cord-021424-kocwsyi7 217 11 for for IN cord-021424-kocwsyi7 217 12 biomarker biomarker NN cord-021424-kocwsyi7 217 13 discovery discovery NN cord-021424-kocwsyi7 217 14 and and CC cord-021424-kocwsyi7 217 15 for for IN cord-021424-kocwsyi7 217 16 clinical clinical JJ cord-021424-kocwsyi7 217 17 trials trial NNS cord-021424-kocwsyi7 218 1 ( ( -LRB- cord-021424-kocwsyi7 218 2 Debey Debey NNP cord-021424-kocwsyi7 218 3 et et NNP cord-021424-kocwsyi7 218 4 al al NNP cord-021424-kocwsyi7 218 5 . . NNP cord-021424-kocwsyi7 218 6 , , , cord-021424-kocwsyi7 218 7 2006 2006 CD cord-021424-kocwsyi7 218 8 ; ; . cord-021424-kocwsyi7 219 1 Shou Shou NNP cord-021424-kocwsyi7 219 2 et et NNP cord-021424-kocwsyi7 219 3 al al NNP cord-021424-kocwsyi7 219 4 . . NNP cord-021424-kocwsyi7 219 5 , , , cord-021424-kocwsyi7 219 6 2005 2005 CD cord-021424-kocwsyi7 220 1 ; ; : cord-021424-kocwsyi7 220 2 Zheng Zheng NNP cord-021424-kocwsyi7 220 3 et et NNP cord-021424-kocwsyi7 220 4 al al NNP cord-021424-kocwsyi7 220 5 . . NNP cord-021424-kocwsyi7 220 6 , , , cord-021424-kocwsyi7 220 7 2006 2006 CD cord-021424-kocwsyi7 220 8 ) ) -RRB- cord-021424-kocwsyi7 220 9 . . . cord-021424-kocwsyi7 221 1 There there EX cord-021424-kocwsyi7 221 2 are be VBP cord-021424-kocwsyi7 221 3 still still RB cord-021424-kocwsyi7 221 4 many many JJ cord-021424-kocwsyi7 221 5 hurdles hurdle NNS cord-021424-kocwsyi7 221 6 to to TO cord-021424-kocwsyi7 221 7 be be VB cord-021424-kocwsyi7 221 8 over over IN cord-021424-kocwsyi7 221 9 come come VBN cord-021424-kocwsyi7 221 10 in in IN cord-021424-kocwsyi7 221 11 terms term NNS cord-021424-kocwsyi7 221 12 of of IN cord-021424-kocwsyi7 221 13 application application NN cord-021424-kocwsyi7 221 14 to to IN cord-021424-kocwsyi7 221 15 the the DT cord-021424-kocwsyi7 221 16 clinical clinical JJ cord-021424-kocwsyi7 221 17 setting setting NN cord-021424-kocwsyi7 221 18 including include VBG cord-021424-kocwsyi7 221 19 standardization standardization NN cord-021424-kocwsyi7 221 20 of of IN cord-021424-kocwsyi7 221 21 sample sample NN cord-021424-kocwsyi7 221 22 preparation preparation NN cord-021424-kocwsyi7 221 23 , , , cord-021424-kocwsyi7 221 24 robustness robustness NN cord-021424-kocwsyi7 221 25 of of IN cord-021424-kocwsyi7 221 26 the the DT cord-021424-kocwsyi7 221 27 microarray microarray NN cord-021424-kocwsyi7 221 28 platform platform NN cord-021424-kocwsyi7 221 29 and and CC cord-021424-kocwsyi7 221 30 data datum NNS cord-021424-kocwsyi7 221 31 analysis analysis NN cord-021424-kocwsyi7 221 32 , , , cord-021424-kocwsyi7 221 33 cost cost VBP cord-021424-kocwsyi7 221 34 quality quality NN cord-021424-kocwsyi7 221 35 assurance assurance NN cord-021424-kocwsyi7 221 36 and and CC cord-021424-kocwsyi7 221 37 so so RB cord-021424-kocwsyi7 221 38 on on RB cord-021424-kocwsyi7 221 39 ( ( -LRB- cord-021424-kocwsyi7 222 1 Abdullah Abdullah NNP cord-021424-kocwsyi7 222 2 - - HYPH cord-021424-kocwsyi7 222 3 Sayani Sayani NNP cord-021424-kocwsyi7 222 4 et et NNP cord-021424-kocwsyi7 222 5 al al NNP cord-021424-kocwsyi7 222 6 . . NNP cord-021424-kocwsyi7 222 7 , , , cord-021424-kocwsyi7 222 8 2006 2006 CD cord-021424-kocwsyi7 222 9 ) ) -RRB- cord-021424-kocwsyi7 222 10 . . . cord-021424-kocwsyi7 223 1 The the DT cord-021424-kocwsyi7 223 2 introduction introduction NN cord-021424-kocwsyi7 223 3 of of IN cord-021424-kocwsyi7 223 4 genetic genetic JJ cord-021424-kocwsyi7 223 5 or or CC cord-021424-kocwsyi7 223 6 genomic genomic JJ cord-021424-kocwsyi7 223 7 screening screening NN cord-021424-kocwsyi7 223 8 into into IN cord-021424-kocwsyi7 223 9 the the DT cord-021424-kocwsyi7 223 10 clinical clinical JJ cord-021424-kocwsyi7 223 11 setting setting NN cord-021424-kocwsyi7 223 12 for for IN cord-021424-kocwsyi7 223 13 infectious infectious JJ cord-021424-kocwsyi7 223 14 disease disease NN cord-021424-kocwsyi7 223 15 will will MD cord-021424-kocwsyi7 223 16 no no RB cord-021424-kocwsyi7 223 17 doubt doubt RB cord-021424-kocwsyi7 223 18 occur occur VB cord-021424-kocwsyi7 223 19 in in IN cord-021424-kocwsyi7 223 20 the the DT cord-021424-kocwsyi7 223 21 near near JJ cord-021424-kocwsyi7 223 22 future future NN cord-021424-kocwsyi7 223 23 . . . cord-021424-kocwsyi7 224 1 I -PRON- PRP cord-021424-kocwsyi7 224 2 would would MD cord-021424-kocwsyi7 224 3 like like VB cord-021424-kocwsyi7 224 4 to to TO cord-021424-kocwsyi7 224 5 thank thank VB cord-021424-kocwsyi7 224 6 Stephanie Stephanie NNP cord-021424-kocwsyi7 224 7 Palmer Palmer NNP cord-021424-kocwsyi7 224 8 for for IN cord-021424-kocwsyi7 224 9 help help NN cord-021424-kocwsyi7 224 10 with with IN cord-021424-kocwsyi7 224 11 preparation preparation NN cord-021424-kocwsyi7 224 12 and and CC cord-021424-kocwsyi7 224 13 proof proof NN cord-021424-kocwsyi7 224 14 - - HYPH cord-021424-kocwsyi7 224 15 reading reading NN cord-021424-kocwsyi7 224 16 of of IN cord-021424-kocwsyi7 224 17 the the DT cord-021424-kocwsyi7 224 18 manuscript manuscript NN cord-021424-kocwsyi7 224 19 . . . cord-021424-kocwsyi7 225 1 Technology technology NN cord-021424-kocwsyi7 225 2 insight insight NN cord-021424-kocwsyi7 225 3 : : : cord-021424-kocwsyi7 226 1 Tuning tune VBG cord-021424-kocwsyi7 226 2 into into IN cord-021424-kocwsyi7 226 3 the the DT cord-021424-kocwsyi7 226 4 genetic genetic JJ cord-021424-kocwsyi7 226 5 orchestra orchestra NN cord-021424-kocwsyi7 226 6 using use VBG cord-021424-kocwsyi7 226 7 microarrays microarray NNS cord-021424-kocwsyi7 226 8 - - : cord-021424-kocwsyi7 226 9 limitations limitation NNS cord-021424-kocwsyi7 226 10 of of IN cord-021424-kocwsyi7 226 11 DNA dna NN cord-021424-kocwsyi7 226 12 microarrays microarray NNS cord-021424-kocwsyi7 226 13 in in IN cord-021424-kocwsyi7 226 14 clinical clinical JJ cord-021424-kocwsyi7 226 15 practice practice NN cord-021424-kocwsyi7 227 1 A a DT cord-021424-kocwsyi7 227 2 systems system NNS cord-021424-kocwsyi7 227 3 approach approach NN cord-021424-kocwsyi7 227 4 to to IN cord-021424-kocwsyi7 227 5 dissecting dissect VBG cord-021424-kocwsyi7 227 6 immunity immunity NN cord-021424-kocwsyi7 227 7 and and CC cord-021424-kocwsyi7 227 8 infl infl NN cord-021424-kocwsyi7 227 9 ammation ammation NNP cord-021424-kocwsyi7 227 10 Genetic genetic JJ cord-021424-kocwsyi7 227 11 dissection dissection NN cord-021424-kocwsyi7 227 12 of of IN cord-021424-kocwsyi7 227 13 immunity immunity NN cord-021424-kocwsyi7 227 14 in in IN cord-021424-kocwsyi7 227 15 leprosy leprosy NN cord-021424-kocwsyi7 227 16 TLR4 tlr4 CD cord-021424-kocwsyi7 227 17 mutations mutation NNS cord-021424-kocwsyi7 227 18 are be VBP cord-021424-kocwsyi7 227 19 associated associate VBN cord-021424-kocwsyi7 227 20 with with IN cord-021424-kocwsyi7 227 21 endotoxin endotoxin NN cord-021424-kocwsyi7 227 22 hyporesponsiveness hyporesponsiveness NN cord-021424-kocwsyi7 227 23 in in IN cord-021424-kocwsyi7 227 24 humans human NNS cord-021424-kocwsyi7 227 25 Integrated Integrated NNP cord-021424-kocwsyi7 227 26 molecular molecular JJ cord-021424-kocwsyi7 227 27 signature signature NN cord-021424-kocwsyi7 227 28 of of IN cord-021424-kocwsyi7 227 29 disease disease NN cord-021424-kocwsyi7 227 30 : : : cord-021424-kocwsyi7 228 1 Analysis analysis NN cord-021424-kocwsyi7 228 2 of of IN cord-021424-kocwsyi7 228 3 infl infl NNP cord-021424-kocwsyi7 228 4 uenza uenza NNP cord-021424-kocwsyi7 228 5 virus virus NN cord-021424-kocwsyi7 228 6 - - HYPH cord-021424-kocwsyi7 228 7 infected infect VBN cord-021424-kocwsyi7 228 8 macaques macaque NNS cord-021424-kocwsyi7 228 9 through through IN cord-021424-kocwsyi7 228 10 functional functional JJ cord-021424-kocwsyi7 228 11 genomics genomic NNS cord-021424-kocwsyi7 228 12 and and CC cord-021424-kocwsyi7 228 13 proteomics proteomic NNS cord-021424-kocwsyi7 229 1 Nramp1 Nramp1 NNP cord-021424-kocwsyi7 229 2 : : : cord-021424-kocwsyi7 230 1 A a DT cord-021424-kocwsyi7 230 2 link link NN cord-021424-kocwsyi7 230 3 between between IN cord-021424-kocwsyi7 230 4 intracellular intracellular JJ cord-021424-kocwsyi7 230 5 iron iron NN cord-021424-kocwsyi7 230 6 transport transport NN cord-021424-kocwsyi7 230 7 and and CC cord-021424-kocwsyi7 230 8 innate innate JJ cord-021424-kocwsyi7 230 9 resistance resistance NN cord-021424-kocwsyi7 230 10 to to IN cord-021424-kocwsyi7 230 11 intracellular intracellular JJ cord-021424-kocwsyi7 230 12 pathogens pathogen NNS cord-021424-kocwsyi7 230 13 Genealogies genealogy NNS cord-021424-kocwsyi7 230 14 of of IN cord-021424-kocwsyi7 230 15 mouse mouse NN cord-021424-kocwsyi7 230 16 inbred inbreed VBN cord-021424-kocwsyi7 230 17 strains strain NNS cord-021424-kocwsyi7 230 18 Toward toward IN cord-021424-kocwsyi7 230 19 the the DT cord-021424-kocwsyi7 230 20 1,000 1,000 CD cord-021424-kocwsyi7 230 21 dollars dollar NNS cord-021424-kocwsyi7 230 22 human human JJ cord-021424-kocwsyi7 230 23 genome genome NN cord-021424-kocwsyi7 230 24 Innate innate VBP cord-021424-kocwsyi7 230 25 immune immune JJ cord-021424-kocwsyi7 230 26 sensing sensing NN cord-021424-kocwsyi7 230 27 and and CC cord-021424-kocwsyi7 230 28 its -PRON- PRP$ cord-021424-kocwsyi7 230 29 roots root NNS cord-021424-kocwsyi7 230 30 : : : cord-021424-kocwsyi7 230 31 The the DT cord-021424-kocwsyi7 230 32 story story NN cord-021424-kocwsyi7 230 33 of of IN cord-021424-kocwsyi7 230 34 endotoxin endotoxin NN cord-021424-kocwsyi7 230 35 Cutting cutting NN cord-021424-kocwsyi7 230 36 edge edge NN cord-021424-kocwsyi7 230 37 : : : cord-021424-kocwsyi7 230 38 A a DT cord-021424-kocwsyi7 230 39 Toll toll NN cord-021424-kocwsyi7 230 40 - - HYPH cord-021424-kocwsyi7 230 41 like like JJ cord-021424-kocwsyi7 230 42 receptor receptor NN cord-021424-kocwsyi7 230 43 2 2 CD cord-021424-kocwsyi7 230 44 polymorphism polymorphism NN cord-021424-kocwsyi7 230 45 that that WDT cord-021424-kocwsyi7 230 46 is be VBZ cord-021424-kocwsyi7 230 47 associated associate VBN cord-021424-kocwsyi7 230 48 with with IN cord-021424-kocwsyi7 230 49 lepromatous lepromatous JJ cord-021424-kocwsyi7 230 50 leprosy leprosy NN cord-021424-kocwsyi7 230 51 is be VBZ cord-021424-kocwsyi7 230 52 unable unable JJ cord-021424-kocwsyi7 230 53 to to TO cord-021424-kocwsyi7 230 54 mediate mediate VB cord-021424-kocwsyi7 230 55 mycobacterial mycobacterial JJ cord-021424-kocwsyi7 230 56 signaling signaling NN cord-021424-kocwsyi7 231 1 Stereotyped stereotyped JJ cord-021424-kocwsyi7 231 2 and and CC cord-021424-kocwsyi7 231 3 specifi specifi NNP cord-021424-kocwsyi7 231 4 c c NN cord-021424-kocwsyi7 231 5 gene gene NN cord-021424-kocwsyi7 231 6 expression expression NN cord-021424-kocwsyi7 231 7 programs program NNS cord-021424-kocwsyi7 231 8 in in IN cord-021424-kocwsyi7 231 9 human human JJ cord-021424-kocwsyi7 231 10 innate innate JJ cord-021424-kocwsyi7 231 11 immune immune JJ cord-021424-kocwsyi7 231 12 responses response NNS cord-021424-kocwsyi7 231 13 to to IN cord-021424-kocwsyi7 231 14 bacteria bacteria NNS cord-021424-kocwsyi7 231 15 Genomic genomic JJ cord-021424-kocwsyi7 231 16 - - HYPH cord-021424-kocwsyi7 231 17 scale scale NN cord-021424-kocwsyi7 231 18 analysis analysis NN cord-021424-kocwsyi7 231 19 of of IN cord-021424-kocwsyi7 231 20 bacterial bacterial JJ cord-021424-kocwsyi7 231 21 gene gene NN cord-021424-kocwsyi7 231 22 and and CC cord-021424-kocwsyi7 231 23 protein protein NN cord-021424-kocwsyi7 231 24 expression expression NN cord-021424-kocwsyi7 231 25 in in IN cord-021424-kocwsyi7 231 26 the the DT cord-021424-kocwsyi7 231 27 host host NN cord-021424-kocwsyi7 231 28 Chips chip NNS cord-021424-kocwsyi7 231 29 with with IN cord-021424-kocwsyi7 231 30 everything everything NN cord-021424-kocwsyi7 231 31 : : : cord-021424-kocwsyi7 231 32 DNA dna NN cord-021424-kocwsyi7 231 33 microarrays microarray NNS cord-021424-kocwsyi7 231 34 in in IN cord-021424-kocwsyi7 231 35 infectious infectious JJ cord-021424-kocwsyi7 231 36 diseases disease NNS cord-021424-kocwsyi7 231 37 Genetic genetic JJ cord-021424-kocwsyi7 231 38 control control NN cord-021424-kocwsyi7 231 39 of of IN cord-021424-kocwsyi7 231 40 visceral visceral JJ cord-021424-kocwsyi7 231 41 l l NNP cord-021424-kocwsyi7 231 42 eishmaniasis eishmaniasis NN cord-021424-kocwsyi7 231 43 in in IN cord-021424-kocwsyi7 231 44 a a DT cord-021424-kocwsyi7 231 45 Sudanese sudanese JJ cord-021424-kocwsyi7 231 46 population population NN cord-021424-kocwsyi7 232 1 : : : cord-021424-kocwsyi7 232 2 Candidate candidate NN cord-021424-kocwsyi7 232 3 gene gene NN cord-021424-kocwsyi7 232 4 testing testing NN cord-021424-kocwsyi7 232 5 indicates indicate VBZ cord-021424-kocwsyi7 232 6 a a DT cord-021424-kocwsyi7 232 7 linkage linkage NN cord-021424-kocwsyi7 232 8 to to IN cord-021424-kocwsyi7 232 9 the the DT cord-021424-kocwsyi7 232 10 NRAMP1 NRAMP1 NNP cord-021424-kocwsyi7 232 11 region region NN cord-021424-kocwsyi7 232 12 Molecular molecular JJ cord-021424-kocwsyi7 232 13 signatures signature NNS cord-021424-kocwsyi7 232 14 for for IN cord-021424-kocwsyi7 232 15 diagnosis diagnosis NN cord-021424-kocwsyi7 232 16 of of IN cord-021424-kocwsyi7 232 17 infection infection NN cord-021424-kocwsyi7 232 18 : : : cord-021424-kocwsyi7 232 19 Application application NN cord-021424-kocwsyi7 232 20 of of IN cord-021424-kocwsyi7 232 21 microarray microarray NN cord-021424-kocwsyi7 232 22 technology technology NN cord-021424-kocwsyi7 232 23 Bacterial bacterial JJ cord-021424-kocwsyi7 232 24 genomes genome NNS cord-021424-kocwsyi7 232 25 and and CC cord-021424-kocwsyi7 232 26 infectious infectious JJ cord-021424-kocwsyi7 232 27 diseases disease NNS cord-021424-kocwsyi7 233 1 Genetic genetic JJ cord-021424-kocwsyi7 233 2 susceptibility susceptibility NN cord-021424-kocwsyi7 233 3 to to IN cord-021424-kocwsyi7 233 4 infectious infectious JJ cord-021424-kocwsyi7 233 5 diseases disease NNS cord-021424-kocwsyi7 233 6 Toll toll NN cord-021424-kocwsyi7 233 7 - - HYPH cord-021424-kocwsyi7 233 8 like like JJ cord-021424-kocwsyi7 233 9 receptors receptor NNS cord-021424-kocwsyi7 233 10 in in IN cord-021424-kocwsyi7 233 11 the the DT cord-021424-kocwsyi7 233 12 pathogenesis pathogenesis NN cord-021424-kocwsyi7 233 13 of of IN cord-021424-kocwsyi7 233 14 human human JJ cord-021424-kocwsyi7 233 15 disease disease NN cord-021424-kocwsyi7 233 16 Genetic genetic JJ cord-021424-kocwsyi7 233 17 regulation regulation NN cord-021424-kocwsyi7 233 18 of of IN cord-021424-kocwsyi7 233 19 endotoxininduced endotoxininduced JJ cord-021424-kocwsyi7 233 20 airway airway NN cord-021424-kocwsyi7 233 21 disease disease NN cord-021424-kocwsyi7 234 1 The the DT cord-021424-kocwsyi7 234 2 genetic genetic JJ cord-021424-kocwsyi7 234 3 dissection dissection NN cord-021424-kocwsyi7 234 4 of of IN cord-021424-kocwsyi7 234 5 immune immune JJ cord-021424-kocwsyi7 234 6 response response NN cord-021424-kocwsyi7 234 7 using use VBG cord-021424-kocwsyi7 234 8 gene gene NN cord-021424-kocwsyi7 234 9 - - HYPH cord-021424-kocwsyi7 234 10 expression expression NN cord-021424-kocwsyi7 234 11 studies study NNS cord-021424-kocwsyi7 234 12 and and CC cord-021424-kocwsyi7 234 13 genome genome NN cord-021424-kocwsyi7 234 14 mapping mapping NN cord-021424-kocwsyi7 234 15 Genetic genetic JJ cord-021424-kocwsyi7 234 16 restriction restriction NN cord-021424-kocwsyi7 234 17 of of IN cord-021424-kocwsyi7 234 18 HIV-1 HIV-1 NNP cord-021424-kocwsyi7 234 19 infection infection NN cord-021424-kocwsyi7 234 20 and and CC cord-021424-kocwsyi7 234 21 progression progression NN cord-021424-kocwsyi7 234 22 to to IN cord-021424-kocwsyi7 234 23 AIDS AIDS NNP cord-021424-kocwsyi7 234 24 by by IN cord-021424-kocwsyi7 234 25 a a DT cord-021424-kocwsyi7 234 26 deletion deletion NN cord-021424-kocwsyi7 234 27 allele allele NN cord-021424-kocwsyi7 234 28 of of IN cord-021424-kocwsyi7 234 29 the the DT cord-021424-kocwsyi7 234 30 CKR5 ckr5 JJ cord-021424-kocwsyi7 234 31 structural structural JJ cord-021424-kocwsyi7 234 32 gene gene NN cord-021424-kocwsyi7 234 33 . . . cord-021424-kocwsyi7 235 1 Hemophilia Hemophilia NNP cord-021424-kocwsyi7 235 2 Growth Growth NNP cord-021424-kocwsyi7 235 3 and and CC cord-021424-kocwsyi7 235 4 Development Development NNP cord-021424-kocwsyi7 235 5 Study Study NNP cord-021424-kocwsyi7 235 6 , , , cord-021424-kocwsyi7 235 7 Multicenter Multicenter NNP cord-021424-kocwsyi7 235 8 AIDS AIDS NNP cord-021424-kocwsyi7 235 9 Cohort Cohort NNP cord-021424-kocwsyi7 235 10 Study Study NNP cord-021424-kocwsyi7 235 11 A a DT cord-021424-kocwsyi7 235 12 highly highly RB cord-021424-kocwsyi7 235 13 standardized standardized JJ cord-021424-kocwsyi7 235 14 , , , cord-021424-kocwsyi7 235 15 robust robust JJ cord-021424-kocwsyi7 235 16 , , , cord-021424-kocwsyi7 235 17 and and CC cord-021424-kocwsyi7 235 18 cost cost NN cord-021424-kocwsyi7 235 19 - - HYPH cord-021424-kocwsyi7 235 20 effective effective JJ cord-021424-kocwsyi7 235 21 method method NN cord-021424-kocwsyi7 235 22 for for IN cord-021424-kocwsyi7 235 23 genome genome NN cord-021424-kocwsyi7 235 24 - - HYPH cord-021424-kocwsyi7 235 25 wide wide JJ cord-021424-kocwsyi7 235 26 transcriptome transcriptome NN cord-021424-kocwsyi7 235 27 analysis analysis NN cord-021424-kocwsyi7 235 28 of of IN cord-021424-kocwsyi7 235 29 peripheral peripheral JJ cord-021424-kocwsyi7 235 30 blood blood NN cord-021424-kocwsyi7 235 31 applicable applicable JJ cord-021424-kocwsyi7 235 32 to to IN cord-021424-kocwsyi7 235 33 large large JJ cord-021424-kocwsyi7 235 34 - - HYPH cord-021424-kocwsyi7 235 35 scale scale NN cord-021424-kocwsyi7 235 36 clinical clinical JJ cord-021424-kocwsyi7 235 37 trials trial NNS cord-021424-kocwsyi7 236 1 Gene gene NN cord-021424-kocwsyi7 236 2 - - HYPH cord-021424-kocwsyi7 236 3 expression expression NN cord-021424-kocwsyi7 236 4 profi profi NNP cord-021424-kocwsyi7 236 5 ling ling NNP cord-021424-kocwsyi7 236 6 discriminates discriminate VBZ cord-021424-kocwsyi7 236 7 between between IN cord-021424-kocwsyi7 236 8 cerebral cerebral JJ cord-021424-kocwsyi7 236 9 malaria malaria NN cord-021424-kocwsyi7 236 10 ( ( -LRB- cord-021424-kocwsyi7 236 11 CM)-susceptible cm)-susceptible CD cord-021424-kocwsyi7 236 12 mice mouse NNS cord-021424-kocwsyi7 236 13 and and CC cord-021424-kocwsyi7 236 14 CM cm NN cord-021424-kocwsyi7 236 15 - - HYPH cord-021424-kocwsyi7 236 16 resistant resistant JJ cord-021424-kocwsyi7 236 17 mice mouse NNS cord-021424-kocwsyi7 236 18 HLA HLA NNP cord-021424-kocwsyi7 236 19 - - HYPH cord-021424-kocwsyi7 236 20 DRB1 DRB1 NNP cord-021424-kocwsyi7 237 1 * * NFP cord-021424-kocwsyi7 237 2 12 12 CD cord-021424-kocwsyi7 237 3 is be VBZ cord-021424-kocwsyi7 237 4 associated associate VBN cord-021424-kocwsyi7 237 5 with with IN cord-021424-kocwsyi7 237 6 protection protection NN cord-021424-kocwsyi7 237 7 against against IN cord-021424-kocwsyi7 237 8 complicated complicated JJ cord-021424-kocwsyi7 237 9 typhoid typhoid NN cord-021424-kocwsyi7 237 10 fever fever NN cord-021424-kocwsyi7 237 11 , , , cord-021424-kocwsyi7 237 12 independent independent JJ cord-021424-kocwsyi7 237 13 of of IN cord-021424-kocwsyi7 237 14 tumour tumour NN cord-021424-kocwsyi7 237 15 necrosis necrosis NN cord-021424-kocwsyi7 237 16 factor factor NN cord-021424-kocwsyi7 237 17 alpha alpha NN cord-021424-kocwsyi7 237 18 Personalized Personalized NNP cord-021424-kocwsyi7 237 19 medicine medicine NN cord-021424-kocwsyi7 237 20 and and CC cord-021424-kocwsyi7 237 21 development development NN cord-021424-kocwsyi7 237 22 of of IN cord-021424-kocwsyi7 237 23 targeted target VBN cord-021424-kocwsyi7 237 24 therapies therapy NNS cord-021424-kocwsyi7 237 25 : : : cord-021424-kocwsyi7 238 1 The the DT cord-021424-kocwsyi7 238 2 upcoming upcoming JJ cord-021424-kocwsyi7 238 3 challenge challenge NN cord-021424-kocwsyi7 238 4 for for IN cord-021424-kocwsyi7 238 5 d d NNP cord-021424-kocwsyi7 238 6 iagnostic iagnostic JJ cord-021424-kocwsyi7 238 7 molecular molecular JJ cord-021424-kocwsyi7 238 8 pathology pathology NN cord-021424-kocwsyi7 238 9 . . . cord-021424-kocwsyi7 239 1 A a DT cord-021424-kocwsyi7 239 2 review review NN cord-021424-kocwsyi7 240 1 Glucocorticoid Glucocorticoid NNP cord-021424-kocwsyi7 240 2 administration administration NN cord-021424-kocwsyi7 240 3 accelerates accelerate VBZ cord-021424-kocwsyi7 240 4 mortality mortality NN cord-021424-kocwsyi7 240 5 of of IN cord-021424-kocwsyi7 240 6 pneumovirus pneumovirus JJ cord-021424-kocwsyi7 240 7 - - HYPH cord-021424-kocwsyi7 240 8 infected infect VBN cord-021424-kocwsyi7 240 9 mice mouse NNS cord-021424-kocwsyi7 240 10 Comparative Comparative NNP cord-021424-kocwsyi7 240 11 phylogenomics phylogenomic NNS cord-021424-kocwsyi7 240 12 of of IN cord-021424-kocwsyi7 240 13 pathogenic pathogenic JJ cord-021424-kocwsyi7 240 14 bacteria bacteria NNS cord-021424-kocwsyi7 240 15 by by IN cord-021424-kocwsyi7 240 16 microarray microarray NN cord-021424-kocwsyi7 240 17 analysis analysis NN cord-021424-kocwsyi7 240 18 HIV-1 HIV-1 NNP cord-021424-kocwsyi7 240 19 entry entry NN cord-021424-kocwsyi7 240 20 into into IN cord-021424-kocwsyi7 240 21 CD4 CD4 NNP cord-021424-kocwsyi7 240 22 ϩ ϩ NN cord-021424-kocwsyi7 240 23 cells cell NNS cord-021424-kocwsyi7 240 24 is be VBZ cord-021424-kocwsyi7 240 25 mediated mediate VBN cord-021424-kocwsyi7 240 26 by by IN cord-021424-kocwsyi7 240 27 the the DT cord-021424-kocwsyi7 240 28 chemokine chemokine NN cord-021424-kocwsyi7 240 29 receptor receptor NN cord-021424-kocwsyi7 240 30 CC CC NNP cord-021424-kocwsyi7 240 31 - - HYPH cord-021424-kocwsyi7 240 32 CKR-5 CKR-5 NNP cord-021424-kocwsyi7 240 33 Genes gene NNS cord-021424-kocwsyi7 240 34 of of IN cord-021424-kocwsyi7 240 35 the the DT cord-021424-kocwsyi7 240 36 class class NN cord-021424-kocwsyi7 240 37 II II NNP cord-021424-kocwsyi7 240 38 and and CC cord-021424-kocwsyi7 240 39 class class NN cord-021424-kocwsyi7 240 40 III iii CD cord-021424-kocwsyi7 240 41 major major JJ cord-021424-kocwsyi7 240 42 histocompatibility histocompatibility NN cord-021424-kocwsyi7 240 43 complex complex NN cord-021424-kocwsyi7 240 44 are be VBP cord-021424-kocwsyi7 240 45 associated associate VBN cord-021424-kocwsyi7 240 46 with with IN cord-021424-kocwsyi7 240 47 typhoid typhoid NN cord-021424-kocwsyi7 240 48 fever fever NN cord-021424-kocwsyi7 240 49 in in IN cord-021424-kocwsyi7 240 50 Vietnam Vietnam NNP cord-021424-kocwsyi7 240 51 Functional functional JJ cord-021424-kocwsyi7 240 52 genomics genomic NNS cord-021424-kocwsyi7 240 53 and and CC cord-021424-kocwsyi7 240 54 gene gene NN cord-021424-kocwsyi7 240 55 expression expression NN cord-021424-kocwsyi7 240 56 profi profi NNP cord-021424-kocwsyi7 240 57 ling ling NNP cord-021424-kocwsyi7 240 58 in in IN cord-021424-kocwsyi7 240 59 sepsis sepsis NN cord-021424-kocwsyi7 240 60 : : : cord-021424-kocwsyi7 241 1 Beyond beyond IN cord-021424-kocwsyi7 241 2 class class NN cord-021424-kocwsyi7 241 3 prediction prediction NN cord-021424-kocwsyi7 241 4 Effects effect NNS cord-021424-kocwsyi7 241 5 of of IN cord-021424-kocwsyi7 241 6 functional functional JJ cord-021424-kocwsyi7 241 7 Tolllike Tolllike NNP cord-021424-kocwsyi7 241 8 receptor-4 receptor-4 NNP cord-021424-kocwsyi7 241 9 mutations mutation NNS cord-021424-kocwsyi7 241 10 on on IN cord-021424-kocwsyi7 241 11 the the DT cord-021424-kocwsyi7 241 12 immune immune JJ cord-021424-kocwsyi7 241 13 response response NN cord-021424-kocwsyi7 241 14 to to IN cord-021424-kocwsyi7 241 15 human human JJ cord-021424-kocwsyi7 241 16 and and CC cord-021424-kocwsyi7 241 17 experimental experimental JJ cord-021424-kocwsyi7 241 18 sepsis sepsis NN cord-021424-kocwsyi7 241 19 Evolutionary evolutionary JJ cord-021424-kocwsyi7 241 20 genomics genomic NNS cord-021424-kocwsyi7 241 21 of of IN cord-021424-kocwsyi7 241 22 pathogenic pathogenic JJ cord-021424-kocwsyi7 241 23 bacteria bacteria NNS cord-021424-kocwsyi7 241 24 Dendritic dendritic JJ cord-021424-kocwsyi7 241 25 cells cell NNS cord-021424-kocwsyi7 241 26 in in IN cord-021424-kocwsyi7 241 27 pathogen pathogen NN cord-021424-kocwsyi7 241 28 recognition recognition NN cord-021424-kocwsyi7 241 29 and and CC cord-021424-kocwsyi7 241 30 induction induction NN cord-021424-kocwsyi7 241 31 of of IN cord-021424-kocwsyi7 241 32 immune immune JJ cord-021424-kocwsyi7 241 33 responses response NNS cord-021424-kocwsyi7 241 34 : : : cord-021424-kocwsyi7 241 35 A a DT cord-021424-kocwsyi7 241 36 functional functional JJ cord-021424-kocwsyi7 241 37 genomics genomic NNS cord-021424-kocwsyi7 241 38 approach approach NN cord-021424-kocwsyi7 241 39 Genetics genetic NNS cord-021424-kocwsyi7 241 40 of of IN cord-021424-kocwsyi7 241 41 infectious infectious JJ cord-021424-kocwsyi7 241 42 diseases disease NNS cord-021424-kocwsyi7 241 43 Regulation regulation NN cord-021424-kocwsyi7 241 44 of of IN cord-021424-kocwsyi7 241 45 gene gene NN cord-021424-kocwsyi7 241 46 expression expression NN cord-021424-kocwsyi7 241 47 in in IN cord-021424-kocwsyi7 241 48 mouse mouse NN cord-021424-kocwsyi7 241 49 macrophages macrophage NNS cord-021424-kocwsyi7 242 1 stimulated stimulate VBN cord-021424-kocwsyi7 242 2 with with IN cord-021424-kocwsyi7 242 3 bacterial bacterial JJ cord-021424-kocwsyi7 242 4 CpG CpG NNP cord-021424-kocwsyi7 242 5 - - HYPH cord-021424-kocwsyi7 242 6 DNA DNA NNP cord-021424-kocwsyi7 242 7 and and CC cord-021424-kocwsyi7 242 8 lipopolysaccharide lipopolysaccharide NN cord-021424-kocwsyi7 242 9 HLA HLA NNP cord-021424-kocwsyi7 242 10 and and CC cord-021424-kocwsyi7 242 11 disease disease NN cord-021424-kocwsyi7 243 1 The the DT cord-021424-kocwsyi7 243 2 Bcg Bcg NNP cord-021424-kocwsyi7 243 3 / / SYM cord-021424-kocwsyi7 243 4 Ity Ity NNP cord-021424-kocwsyi7 243 5 / / SYM cord-021424-kocwsyi7 243 6 Lsh Lsh NNP cord-021424-kocwsyi7 243 7 locus locus NN cord-021424-kocwsyi7 243 8 : : : cord-021424-kocwsyi7 243 9 genetic genetic JJ cord-021424-kocwsyi7 243 10 transfer transfer NN cord-021424-kocwsyi7 243 11 of of IN cord-021424-kocwsyi7 243 12 resistance resistance NN cord-021424-kocwsyi7 243 13 to to IN cord-021424-kocwsyi7 243 14 infections infection NNS cord-021424-kocwsyi7 243 15 in in IN cord-021424-kocwsyi7 243 16 C57BL/6J C57BL/6J NNP cord-021424-kocwsyi7 243 17 mice mouse NNS cord-021424-kocwsyi7 243 18 transgenic transgenic JJ cord-021424-kocwsyi7 243 19 for for IN cord-021424-kocwsyi7 243 20 the the DT cord-021424-kocwsyi7 243 21 Nramp1 Nramp1 NNP cord-021424-kocwsyi7 243 22 Gly169 Gly169 NNS cord-021424-kocwsyi7 243 23 allele allele NN cord-021424-kocwsyi7 244 1 A a DT cord-021424-kocwsyi7 244 2 common common JJ cord-021424-kocwsyi7 244 3 dominant dominant JJ cord-021424-kocwsyi7 244 4 TLR5 TLR5 NNP cord-021424-kocwsyi7 244 5 stop stop NN cord-021424-kocwsyi7 245 1 codon codon NNP cord-021424-kocwsyi7 245 2 polymorphism polymorphism NN cord-021424-kocwsyi7 245 3 abolishes abolish VBZ cord-021424-kocwsyi7 245 4 fl fl NNP cord-021424-kocwsyi7 245 5 agellin agellin NNP cord-021424-kocwsyi7 245 6 signaling signaling NN cord-021424-kocwsyi7 245 7 and and CC cord-021424-kocwsyi7 245 8 is be VBZ cord-021424-kocwsyi7 245 9 associated associate VBN cord-021424-kocwsyi7 245 10 with with IN cord-021424-kocwsyi7 245 11 susceptibility susceptibility NN cord-021424-kocwsyi7 245 12 to to IN cord-021424-kocwsyi7 245 13 legionnaires legionnaire NNS cord-021424-kocwsyi7 245 14 ' ' POS cord-021424-kocwsyi7 245 15 disease disease NN cord-021424-kocwsyi7 245 16 A a DT cord-021424-kocwsyi7 245 17 classifi classifi NN cord-021424-kocwsyi7 245 18 cation cation NN cord-021424-kocwsyi7 245 19 of of IN cord-021424-kocwsyi7 245 20 tasks task NNS cord-021424-kocwsyi7 245 21 for for IN cord-021424-kocwsyi7 245 22 the the DT cord-021424-kocwsyi7 245 23 systematic systematic JJ cord-021424-kocwsyi7 245 24 study study NN cord-021424-kocwsyi7 245 25 of of IN cord-021424-kocwsyi7 245 26 immune immune JJ cord-021424-kocwsyi7 245 27 response response NN cord-021424-kocwsyi7 245 28 using use VBG cord-021424-kocwsyi7 245 29 functional functional JJ cord-021424-kocwsyi7 245 30 genomics genomic NNS cord-021424-kocwsyi7 245 31 data datum NNS cord-021424-kocwsyi7 245 32 New new JJ cord-021424-kocwsyi7 245 33 class class NN cord-021424-kocwsyi7 245 34 I i NN cord-021424-kocwsyi7 245 35 and and CC cord-021424-kocwsyi7 245 36 II II NNP cord-021424-kocwsyi7 245 37 HLA HLA NNP cord-021424-kocwsyi7 245 38 alleles allele NNS cord-021424-kocwsyi7 245 39 strongly strongly RB cord-021424-kocwsyi7 245 40 associated associate VBN cord-021424-kocwsyi7 245 41 with with IN cord-021424-kocwsyi7 245 42 opposite opposite JJ cord-021424-kocwsyi7 245 43 patterns pattern NNS cord-021424-kocwsyi7 245 44 of of IN cord-021424-kocwsyi7 245 45 progression progression NN cord-021424-kocwsyi7 245 46 to to IN cord-021424-kocwsyi7 245 47 AIDS AIDS NNP cord-021424-kocwsyi7 245 48 Chip Chip NNP cord-021424-kocwsyi7 245 49 - - HYPH cord-021424-kocwsyi7 245 50 mediated mediate VBN cord-021424-kocwsyi7 245 51 techniques technique NNS cord-021424-kocwsyi7 246 1 : : : cord-021424-kocwsyi7 246 2 How how WRB cord-021424-kocwsyi7 246 3 close close RB cord-021424-kocwsyi7 246 4 are be VBP cord-021424-kocwsyi7 246 5 we -PRON- PRP cord-021424-kocwsyi7 246 6 to to IN cord-021424-kocwsyi7 246 7 generalised generalised JJ cord-021424-kocwsyi7 246 8 use use NN cord-021424-kocwsyi7 246 9 in in IN cord-021424-kocwsyi7 246 10 the the DT cord-021424-kocwsyi7 246 11 infectious infectious JJ cord-021424-kocwsyi7 246 12 disease disease NN cord-021424-kocwsyi7 246 13 clinic clinic NN cord-021424-kocwsyi7 246 14 ? ? . cord-021424-kocwsyi7 247 1 Genetic genetic JJ cord-021424-kocwsyi7 247 2 susceptibility susceptibility NN cord-021424-kocwsyi7 247 3 to to IN cord-021424-kocwsyi7 247 4 malaria malaria NN cord-021424-kocwsyi7 247 5 and and CC cord-021424-kocwsyi7 247 6 other other JJ cord-021424-kocwsyi7 247 7 infectious infectious JJ cord-021424-kocwsyi7 247 8 diseases disease NNS cord-021424-kocwsyi7 247 9 : : : cord-021424-kocwsyi7 248 1 From from IN cord-021424-kocwsyi7 248 2 the the DT cord-021424-kocwsyi7 248 3 MHC MHC NNP cord-021424-kocwsyi7 248 4 to to IN cord-021424-kocwsyi7 248 5 the the DT cord-021424-kocwsyi7 248 6 whole whole JJ cord-021424-kocwsyi7 248 7 genome genome NN cord-021424-kocwsyi7 249 1 The the DT cord-021424-kocwsyi7 249 2 immunogenetics immunogenetic NNS cord-021424-kocwsyi7 249 3 of of IN cord-021424-kocwsyi7 249 4 resistance resistance NN cord-021424-kocwsyi7 249 5 to to IN cord-021424-kocwsyi7 249 6 malaria malaria NN cord-021424-kocwsyi7 250 1 The the DT cord-021424-kocwsyi7 250 2 plasticity plasticity NN cord-021424-kocwsyi7 250 3 of of IN cord-021424-kocwsyi7 250 4 dendritic dendritic JJ cord-021424-kocwsyi7 250 5 cell cell NN cord-021424-kocwsyi7 250 6 responses response NNS cord-021424-kocwsyi7 250 7 to to IN cord-021424-kocwsyi7 250 8 pathogens pathogen NNS cord-021424-kocwsyi7 250 9 and and CC cord-021424-kocwsyi7 250 10 their -PRON- PRP$ cord-021424-kocwsyi7 250 11 components component NNS cord-021424-kocwsyi7 250 12 Insights insight NNS cord-021424-kocwsyi7 250 13 into into IN cord-021424-kocwsyi7 250 14 host host NN cord-021424-kocwsyi7 250 15 responses response NNS cord-021424-kocwsyi7 250 16 against against IN cord-021424-kocwsyi7 250 17 pathogens pathogen NNS cord-021424-kocwsyi7 250 18 from from IN cord-021424-kocwsyi7 250 19 transcriptional transcriptional JJ cord-021424-kocwsyi7 250 20 profi profi NNP cord-021424-kocwsyi7 250 21 ling ling NNP cord-021424-kocwsyi7 250 22 Identifi Identifi NNP cord-021424-kocwsyi7 250 23 cation cation NN cord-021424-kocwsyi7 250 24 of of IN cord-021424-kocwsyi7 250 25 genes gene NNS cord-021424-kocwsyi7 250 26 involved involve VBN cord-021424-kocwsyi7 250 27 in in IN cord-021424-kocwsyi7 250 28 the the DT cord-021424-kocwsyi7 250 29 host host NN cord-021424-kocwsyi7 250 30 response response NN cord-021424-kocwsyi7 250 31 to to IN cord-021424-kocwsyi7 250 32 neurovirulent neurovirulent NNP cord-021424-kocwsyi7 250 33 alphavirus alphavirus NNP cord-021424-kocwsyi7 250 34 infection infection NN cord-021424-kocwsyi7 251 1 A a DT cord-021424-kocwsyi7 251 2 polymorphism polymorphism NN cord-021424-kocwsyi7 251 3 in in IN cord-021424-kocwsyi7 251 4 the the DT cord-021424-kocwsyi7 251 5 toll toll NN cord-021424-kocwsyi7 251 6 - - HYPH cord-021424-kocwsyi7 251 7 like like JJ cord-021424-kocwsyi7 251 8 receptor receptor NN cord-021424-kocwsyi7 251 9 2 2 CD cord-021424-kocwsyi7 251 10 is be VBZ cord-021424-kocwsyi7 251 11 associated associate VBN cord-021424-kocwsyi7 251 12 with with IN cord-021424-kocwsyi7 251 13 IL-12 IL-12 NNP cord-021424-kocwsyi7 251 14 production production NN cord-021424-kocwsyi7 251 15 from from IN cord-021424-kocwsyi7 251 16 monocyte monocyte NNP cord-021424-kocwsyi7 251 17 in in IN cord-021424-kocwsyi7 251 18 lepromatous lepromatous JJ cord-021424-kocwsyi7 251 19 leprosy leprosy NN cord-021424-kocwsyi7 251 20 Microarray Microarray NNP cord-021424-kocwsyi7 251 21 analysis analysis NN cord-021424-kocwsyi7 251 22 of of IN cord-021424-kocwsyi7 251 23 pathogens pathogen NNS cord-021424-kocwsyi7 251 24 and and CC cord-021424-kocwsyi7 251 25 their -PRON- PRP$ cord-021424-kocwsyi7 251 26 interaction interaction NN cord-021424-kocwsyi7 251 27 with with IN cord-021424-kocwsyi7 251 28 hosts host NNS cord-021424-kocwsyi7 251 29 Virus Virus NNP cord-021424-kocwsyi7 251 30 infection infection NN cord-021424-kocwsyi7 251 31 and and CC cord-021424-kocwsyi7 251 32 the the DT cord-021424-kocwsyi7 251 33 interferon interferon NN cord-021424-kocwsyi7 251 34 response response NN cord-021424-kocwsyi7 251 35 : : : cord-021424-kocwsyi7 251 36 A a DT cord-021424-kocwsyi7 251 37 global global JJ cord-021424-kocwsyi7 251 38 view view NN cord-021424-kocwsyi7 251 39 through through IN cord-021424-kocwsyi7 251 40 functional functional JJ cord-021424-kocwsyi7 251 41 genomics genomic NNS cord-021424-kocwsyi7 251 42 Unlocking unlock VBG cord-021424-kocwsyi7 251 43 the the DT cord-021424-kocwsyi7 251 44 mysteries mystery NNS cord-021424-kocwsyi7 251 45 of of IN cord-021424-kocwsyi7 251 46 virus virus NN cord-021424-kocwsyi7 251 47 - - HYPH cord-021424-kocwsyi7 251 48 host host NN cord-021424-kocwsyi7 251 49 interactions interaction NNS cord-021424-kocwsyi7 251 50 : : : cord-021424-kocwsyi7 251 51 Does do VBZ cord-021424-kocwsyi7 251 52 functional functional JJ cord-021424-kocwsyi7 251 53 genomics genomic NNS cord-021424-kocwsyi7 251 54 hold hold VB cord-021424-kocwsyi7 251 55 the the DT cord-021424-kocwsyi7 251 56 key key NN cord-021424-kocwsyi7 251 57 ? ? . cord-021424-kocwsyi7 252 1 Application application NN cord-021424-kocwsyi7 252 2 of of IN cord-021424-kocwsyi7 252 3 DNA dna NN cord-021424-kocwsyi7 252 4 microarray microarray NN cord-021424-kocwsyi7 252 5 technology technology NN cord-021424-kocwsyi7 252 6 for for IN cord-021424-kocwsyi7 252 7 detection detection NN cord-021424-kocwsyi7 252 8 , , , cord-021424-kocwsyi7 252 9 identifi identifi NNP cord-021424-kocwsyi7 252 10 cation cation NNP cord-021424-kocwsyi7 252 11 , , , cord-021424-kocwsyi7 252 12 and and CC cord-021424-kocwsyi7 252 13 characterization characterization NN cord-021424-kocwsyi7 252 14 of of IN cord-021424-kocwsyi7 252 15 food food NN cord-021424-kocwsyi7 252 16 - - HYPH cord-021424-kocwsyi7 252 17 borne bear VBN cord-021424-kocwsyi7 252 18 pathogens pathogen NNS cord-021424-kocwsyi7 252 19 Association Association NNP cord-021424-kocwsyi7 252 20 of of IN cord-021424-kocwsyi7 252 21 IL12RB1 il12rb1 DT cord-021424-kocwsyi7 252 22 polymorphisms polymorphism NNS cord-021424-kocwsyi7 252 23 with with IN cord-021424-kocwsyi7 252 24 susceptibility susceptibility NN cord-021424-kocwsyi7 252 25 to to IN cord-021424-kocwsyi7 252 26 and and CC cord-021424-kocwsyi7 252 27 severity severity NN cord-021424-kocwsyi7 252 28 of of IN cord-021424-kocwsyi7 252 29 tuberculosis tuberculosis NN cord-021424-kocwsyi7 252 30 in in IN cord-021424-kocwsyi7 252 31 Japanese Japanese NNP cord-021424-kocwsyi7 252 32 : : : cord-021424-kocwsyi7 252 33 A a DT cord-021424-kocwsyi7 252 34 gene gene NN cord-021424-kocwsyi7 252 35 - - HYPH cord-021424-kocwsyi7 252 36 based base VBN cord-021424-kocwsyi7 252 37 association association NN cord-021424-kocwsyi7 252 38 analysis analysis NN cord-021424-kocwsyi7 252 39 of of IN cord-021424-kocwsyi7 252 40 21 21 CD cord-021424-kocwsyi7 252 41 candidate candidate NN cord-021424-kocwsyi7 252 42 genes gene NNS cord-021424-kocwsyi7 252 43 SLC11A1 slc11a1 DT cord-021424-kocwsyi7 253 1 ( ( -LRB- cord-021424-kocwsyi7 253 2 formerly formerly RB cord-021424-kocwsyi7 253 3 NRAMP1 nramp1 DT cord-021424-kocwsyi7 253 4 ) ) -RRB- cord-021424-kocwsyi7 254 1 gene gene NN cord-021424-kocwsyi7 254 2 polymorphisms polymorphism NNS cord-021424-kocwsyi7 254 3 and and CC cord-021424-kocwsyi7 254 4 tuberculosis tuberculosis NN cord-021424-kocwsyi7 254 5 susceptibility susceptibility NN cord-021424-kocwsyi7 254 6 : : : cord-021424-kocwsyi7 255 1 A a DT cord-021424-kocwsyi7 255 2 meta meta JJ cord-021424-kocwsyi7 255 3 - - HYPH cord-021424-kocwsyi7 255 4 analysis analysis NN cord-021424-kocwsyi7 255 5 Human human JJ cord-021424-kocwsyi7 255 6 leukocyte leukocyte NN cord-021424-kocwsyi7 255 7 antigen antigen NN cord-021424-kocwsyi7 255 8 class class NN cord-021424-kocwsyi7 255 9 I i NN cord-021424-kocwsyi7 255 10 and and CC cord-021424-kocwsyi7 255 11 class class NN cord-021424-kocwsyi7 255 12 II II NNP cord-021424-kocwsyi7 255 13 allele allele NN cord-021424-kocwsyi7 255 14 frequencies frequency NNS cord-021424-kocwsyi7 255 15 and and CC cord-021424-kocwsyi7 255 16 HIV-1 HIV-1 NNP cord-021424-kocwsyi7 255 17 infection infection NN cord-021424-kocwsyi7 255 18 associations association NNS cord-021424-kocwsyi7 255 19 in in IN cord-021424-kocwsyi7 255 20 a a DT cord-021424-kocwsyi7 255 21 Chinese chinese JJ cord-021424-kocwsyi7 255 22 cohort cohort NN cord-021424-kocwsyi7 255 23 Genetic genetic JJ cord-021424-kocwsyi7 255 24 susceptibility susceptibility NN cord-021424-kocwsyi7 255 25 to to IN cord-021424-kocwsyi7 255 26 infectious infectious JJ cord-021424-kocwsyi7 255 27 disease disease NN cord-021424-kocwsyi7 255 28 : : : cord-021424-kocwsyi7 255 29 Lessons lesson NNS cord-021424-kocwsyi7 255 30 from from IN cord-021424-kocwsyi7 255 31 mouse mouse NN cord-021424-kocwsyi7 255 32 models model NNS cord-021424-kocwsyi7 255 33 of of IN cord-021424-kocwsyi7 255 34 leishmaniasis leishmaniasis NN cord-021424-kocwsyi7 255 35 Polymorphism polymorphism NN cord-021424-kocwsyi7 255 36 and and CC cord-021424-kocwsyi7 255 37 evolution evolution NN cord-021424-kocwsyi7 255 38 of of IN cord-021424-kocwsyi7 255 39 HLA HLA NNP cord-021424-kocwsyi7 255 40 class class NN cord-021424-kocwsyi7 255 41 I i NN cord-021424-kocwsyi7 255 42 and and CC cord-021424-kocwsyi7 255 43 II II NNP cord-021424-kocwsyi7 255 44 genes gene NNS cord-021424-kocwsyi7 255 45 and and CC cord-021424-kocwsyi7 255 46 molecules molecule NNS cord-021424-kocwsyi7 255 47 Association Association NNP cord-021424-kocwsyi7 255 48 of of IN cord-021424-kocwsyi7 255 49 HLA HLA NNP cord-021424-kocwsyi7 255 50 - - HYPH cord-021424-kocwsyi7 255 51 DR DR NNP cord-021424-kocwsyi7 255 52 , , , cord-021424-kocwsyi7 255 53 -DQ -dq NN cord-021424-kocwsyi7 255 54 , , , cord-021424-kocwsyi7 255 55 and and CC cord-021424-kocwsyi7 255 56 vitamin vitamin NN cord-021424-kocwsyi7 255 57 D d NN cord-021424-kocwsyi7 255 58 receptor receptor NN cord-021424-kocwsyi7 255 59 alleles allele NNS cord-021424-kocwsyi7 255 60 and and CC cord-021424-kocwsyi7 255 61 haplotypes haplotype NNS cord-021424-kocwsyi7 255 62 with with IN cord-021424-kocwsyi7 255 63 tuberculosis tuberculosis NN cord-021424-kocwsyi7 255 64 in in IN cord-021424-kocwsyi7 255 65 the the DT cord-021424-kocwsyi7 255 66 Venda Venda NNP cord-021424-kocwsyi7 255 67 of of IN cord-021424-kocwsyi7 255 68 South South NNP cord-021424-kocwsyi7 255 69 Africa Africa NNP cord-021424-kocwsyi7 255 70 Recognition Recognition NNP cord-021424-kocwsyi7 255 71 of of IN cord-021424-kocwsyi7 255 72 singlestranded singlestranded NNP cord-021424-kocwsyi7 255 73 RNA RNA NNP cord-021424-kocwsyi7 255 74 viruses virus NNS cord-021424-kocwsyi7 255 75 by by IN cord-021424-kocwsyi7 255 76 Toll toll NN cord-021424-kocwsyi7 255 77 - - HYPH cord-021424-kocwsyi7 255 78 like like JJ cord-021424-kocwsyi7 255 79 receptor receptor NN cord-021424-kocwsyi7 255 80 7 7 CD cord-021424-kocwsyi7 255 81 Genomic genomic JJ cord-021424-kocwsyi7 255 82 DNA dna NN cord-021424-kocwsyi7 255 83 microarrays microarray NNS cord-021424-kocwsyi7 255 84 for for IN cord-021424-kocwsyi7 255 85 Entamoeba Entamoeba NNP cord-021424-kocwsyi7 255 86 histolytica histolytica NNP cord-021424-kocwsyi7 255 87 : : : cord-021424-kocwsyi7 255 88 Applications application NNS cord-021424-kocwsyi7 255 89 for for IN cord-021424-kocwsyi7 255 90 use use NN cord-021424-kocwsyi7 255 91 in in IN cord-021424-kocwsyi7 255 92 expression expression NN cord-021424-kocwsyi7 255 93 profi profi NNP cord-021424-kocwsyi7 255 94 ling ling NNP cord-021424-kocwsyi7 255 95 and and CC cord-021424-kocwsyi7 255 96 strain strain VB cord-021424-kocwsyi7 255 97 genotyping genotyping NN cord-021424-kocwsyi7 255 98 Combined combined JJ cord-021424-kocwsyi7 255 99 genotypes genotype NNS cord-021424-kocwsyi7 255 100 of of IN cord-021424-kocwsyi7 255 101 CCR5 CCR5 NNP cord-021424-kocwsyi7 255 102 , , , cord-021424-kocwsyi7 255 103 CCR2 CCR2 NNP cord-021424-kocwsyi7 255 104 , , , cord-021424-kocwsyi7 255 105 SDF1 SDF1 NNP cord-021424-kocwsyi7 255 106 , , , cord-021424-kocwsyi7 255 107 and and CC cord-021424-kocwsyi7 255 108 HLA HLA NNP cord-021424-kocwsyi7 255 109 genes gene NNS cord-021424-kocwsyi7 255 110 can can MD cord-021424-kocwsyi7 255 111 predict predict VB cord-021424-kocwsyi7 255 112 the the DT cord-021424-kocwsyi7 255 113 long long JJ cord-021424-kocwsyi7 255 114 - - HYPH cord-021424-kocwsyi7 255 115 term term NN cord-021424-kocwsyi7 255 116 nonprogressor nonprogressor FW cord-021424-kocwsyi7 255 117 status status NN cord-021424-kocwsyi7 255 118 in in IN cord-021424-kocwsyi7 255 119 human human JJ cord-021424-kocwsyi7 255 120 immunodefi immunodefi NNP cord-021424-kocwsyi7 255 121 ciency ciency NNP cord-021424-kocwsyi7 255 122 virus-1-infected virus-1-infecte VBD cord-021424-kocwsyi7 255 123 individuals individual NNS cord-021424-kocwsyi7 255 124 Knockout Knockout NNP cord-021424-kocwsyi7 255 125 mice mouse NNS cord-021424-kocwsyi7 255 126 : : : cord-021424-kocwsyi7 256 1 A a DT cord-021424-kocwsyi7 256 2 paradigm paradigm NN cord-021424-kocwsyi7 256 3 shift shift NN cord-021424-kocwsyi7 256 4 in in IN cord-021424-kocwsyi7 256 5 modern modern JJ cord-021424-kocwsyi7 256 6 immunology immunology NN cord-021424-kocwsyi7 256 7 Genetic genetic JJ cord-021424-kocwsyi7 256 8 localization localization NN cord-021424-kocwsyi7 256 9 of of IN cord-021424-kocwsyi7 256 10 a a DT cord-021424-kocwsyi7 256 11 locus locus NN cord-021424-kocwsyi7 256 12 controlling control VBG cord-021424-kocwsyi7 256 13 the the DT cord-021424-kocwsyi7 256 14 intensity intensity NN cord-021424-kocwsyi7 256 15 of of IN cord-021424-kocwsyi7 256 16 infection infection NN cord-021424-kocwsyi7 256 17 by by IN cord-021424-kocwsyi7 256 18 Schistosoma Schistosoma NNP cord-021424-kocwsyi7 256 19 mansoni mansoni NN cord-021424-kocwsyi7 256 20 on on IN cord-021424-kocwsyi7 256 21 chromosome chromosome NN cord-021424-kocwsyi7 256 22 5q31-q33 5q31-q33 CD cord-021424-kocwsyi7 256 23 Variation variation NN cord-021424-kocwsyi7 256 24 in in IN cord-021424-kocwsyi7 256 25 the the DT cord-021424-kocwsyi7 256 26 TNF TNF NNP cord-021424-kocwsyi7 256 27 - - HYPH cord-021424-kocwsyi7 256 28 alpha alpha NN cord-021424-kocwsyi7 256 29 promoter promoter NN cord-021424-kocwsyi7 256 30 region region NN cord-021424-kocwsyi7 256 31 associated associate VBN cord-021424-kocwsyi7 256 32 with with IN cord-021424-kocwsyi7 256 33 susceptibility susceptibility NN cord-021424-kocwsyi7 256 34 to to IN cord-021424-kocwsyi7 256 35 cerebral cerebral JJ cord-021424-kocwsyi7 256 36 malaria malaria NN cord-021424-kocwsyi7 256 37 Variants Variants NNPS cord-021424-kocwsyi7 256 38 of of IN cord-021424-kocwsyi7 256 39 HLA HLA NNP cord-021424-kocwsyi7 256 40 - - HYPH cord-021424-kocwsyi7 256 41 DR2/ DR2/ NNP cord-021424-kocwsyi7 256 42 DR51 DR51 NNP cord-021424-kocwsyi7 256 43 group group NN cord-021424-kocwsyi7 256 44 haplotypes haplotype NNS cord-021424-kocwsyi7 256 45 and and CC cord-021424-kocwsyi7 256 46 susceptibility susceptibility NN cord-021424-kocwsyi7 256 47 to to IN cord-021424-kocwsyi7 256 48 tuberculoid tuberculoid NNP cord-021424-kocwsyi7 256 49 leprosy leprosy NN cord-021424-kocwsyi7 256 50 and and CC cord-021424-kocwsyi7 256 51 pulmonary pulmonary JJ cord-021424-kocwsyi7 256 52 tuberculosis tuberculosis NN cord-021424-kocwsyi7 256 53 in in IN cord-021424-kocwsyi7 256 54 Asian asian JJ cord-021424-kocwsyi7 256 55 Indians Indians NNPS cord-021424-kocwsyi7 256 56 Characterization Characterization NNP cord-021424-kocwsyi7 256 57 and and CC cord-021424-kocwsyi7 256 58 functional functional JJ cord-021424-kocwsyi7 256 59 investigation investigation NN cord-021424-kocwsyi7 256 60 of of IN cord-021424-kocwsyi7 256 61 single single JJ cord-021424-kocwsyi7 256 62 nucleotide nucleotide JJ cord-021424-kocwsyi7 256 63 polymorphisms polymorphism NNS cord-021424-kocwsyi7 256 64 ( ( -LRB- cord-021424-kocwsyi7 256 65 SNPs SNPs NNP cord-021424-kocwsyi7 256 66 ) ) -RRB- cord-021424-kocwsyi7 256 67 in in IN cord-021424-kocwsyi7 256 68 the the DT cord-021424-kocwsyi7 256 69 human human JJ cord-021424-kocwsyi7 256 70 TLR5 TLR5 NNP cord-021424-kocwsyi7 256 71 gene gene NN cord-021424-kocwsyi7 256 72 HLA HLA NNP cord-021424-kocwsyi7 256 73 alleles allele NNS cord-021424-kocwsyi7 256 74 in in IN cord-021424-kocwsyi7 256 75 relation relation NN cord-021424-kocwsyi7 256 76 to to IN cord-021424-kocwsyi7 256 77 specifi specifi NN cord-021424-kocwsyi7 256 78 c c NN cord-021424-kocwsyi7 256 79 immunity immunity NN cord-021424-kocwsyi7 256 80 to to IN cord-021424-kocwsyi7 256 81 liver liver NN cord-021424-kocwsyi7 256 82 stage stage NN cord-021424-kocwsyi7 257 1 antigen-1 antigen-1 IN cord-021424-kocwsyi7 257 2 from from IN cord-021424-kocwsyi7 257 3 plasmodium plasmodium NN cord-021424-kocwsyi7 257 4 falciparum falciparum NN cord-021424-kocwsyi7 257 5 in in IN cord-021424-kocwsyi7 257 6 Gabon Gabon NNP cord-021424-kocwsyi7 257 7 Susceptibility Susceptibility NNP cord-021424-kocwsyi7 257 8 to to IN cord-021424-kocwsyi7 257 9 leprosy leprosy NN cord-021424-kocwsyi7 257 10 is be VBZ cord-021424-kocwsyi7 257 11 associated associate VBN cord-021424-kocwsyi7 257 12 with with IN cord-021424-kocwsyi7 257 13 PARK2 PARK2 NNS cord-021424-kocwsyi7 257 14 and and CC cord-021424-kocwsyi7 257 15 PACRG PACRG NNP cord-021424-kocwsyi7 257 16 Gene gene NN cord-021424-kocwsyi7 257 17 - - HYPH cord-021424-kocwsyi7 257 18 expression expression NN cord-021424-kocwsyi7 257 19 patterns pattern NNS cord-021424-kocwsyi7 257 20 in in IN cord-021424-kocwsyi7 257 21 whole whole JJ cord-021424-kocwsyi7 257 22 blood blood NN cord-021424-kocwsyi7 257 23 identify identify VBP cord-021424-kocwsyi7 257 24 subjects subject NNS cord-021424-kocwsyi7 257 25 at at IN cord-021424-kocwsyi7 257 26 risk risk NN cord-021424-kocwsyi7 257 27 for for IN cord-021424-kocwsyi7 257 28 recurrent recurrent JJ cord-021424-kocwsyi7 257 29 tuberculosis tuberculosis NN cord-021424-kocwsyi7 257 30 Genetic genetic JJ cord-021424-kocwsyi7 257 31 susceptibility susceptibility NN cord-021424-kocwsyi7 257 32 to to IN cord-021424-kocwsyi7 257 33 visceral visceral JJ cord-021424-kocwsyi7 257 34 leishmaniasis leishmaniasis NN cord-021424-kocwsyi7 257 35 in in IN cord-021424-kocwsyi7 257 36 The the DT cord-021424-kocwsyi7 257 37 Sudan Sudan NNP cord-021424-kocwsyi7 257 38 : : : cord-021424-kocwsyi7 258 1 Linkage linkage NN cord-021424-kocwsyi7 258 2 and and CC cord-021424-kocwsyi7 258 3 association association NN cord-021424-kocwsyi7 258 4 with with IN cord-021424-kocwsyi7 258 5 IL4 IL4 NNP cord-021424-kocwsyi7 258 6 and and CC cord-021424-kocwsyi7 258 7 IFNGR1 IFNGR1 NNP cord-021424-kocwsyi7 258 8 SLC11A1 SLC11A1 NNP cord-021424-kocwsyi7 258 9 ( ( -LRB- cord-021424-kocwsyi7 258 10 formerly formerly RB cord-021424-kocwsyi7 258 11 NRAMP1 NRAMP1 NNP cord-021424-kocwsyi7 258 12 ) ) -RRB- cord-021424-kocwsyi7 258 13 and and CC cord-021424-kocwsyi7 258 14 susceptibility susceptibility NN cord-021424-kocwsyi7 258 15 to to IN cord-021424-kocwsyi7 258 16 visceral visceral JJ cord-021424-kocwsyi7 258 17 leishmaniasis leishmaniasis NN cord-021424-kocwsyi7 258 18 in in IN cord-021424-kocwsyi7 258 19 The the DT cord-021424-kocwsyi7 258 20 Sudan Sudan NNP cord-021424-kocwsyi7 259 1 The the DT cord-021424-kocwsyi7 259 2 challenge challenge NN cord-021424-kocwsyi7 259 3 of of IN cord-021424-kocwsyi7 259 4 emerging emerge VBG cord-021424-kocwsyi7 259 5 and and CC cord-021424-kocwsyi7 259 6 re re VB cord-021424-kocwsyi7 259 7 - - JJ cord-021424-kocwsyi7 259 8 emerging emerge VBG cord-021424-kocwsyi7 259 9 infectious infectious JJ cord-021424-kocwsyi7 259 10 diseases disease NNS cord-021424-kocwsyi7 259 11 Two two CD cord-021424-kocwsyi7 259 12 types type NNS cord-021424-kocwsyi7 259 13 of of IN cord-021424-kocwsyi7 259 14 murine murine JJ cord-021424-kocwsyi7 259 15 helper helper NN cord-021424-kocwsyi7 259 16 T t NN cord-021424-kocwsyi7 259 17 cell cell NN cord-021424-kocwsyi7 259 18 clone clone NN cord-021424-kocwsyi7 259 19 . . . cord-021424-kocwsyi7 260 1 I. I. NNP cord-021424-kocwsyi7 260 2 Defi Defi NNP cord-021424-kocwsyi7 260 3 nition nition NN cord-021424-kocwsyi7 260 4 according accord VBG cord-021424-kocwsyi7 260 5 to to IN cord-021424-kocwsyi7 260 6 profi profi NNP cord-021424-kocwsyi7 260 7 les les NNP cord-021424-kocwsyi7 260 8 of of IN cord-021424-kocwsyi7 260 9 lymphokine lymphokine NN cord-021424-kocwsyi7 260 10 activities activity NNS cord-021424-kocwsyi7 260 11 and and CC cord-021424-kocwsyi7 260 12 secreted secrete VBD cord-021424-kocwsyi7 260 13 proteins protein NNS cord-021424-kocwsyi7 260 14 Human Human NNP cord-021424-kocwsyi7 260 15 macrophage macrophage NN cord-021424-kocwsyi7 260 16 activation activation NN cord-021424-kocwsyi7 260 17 programs program NNS cord-021424-kocwsyi7 260 18 induced induce VBN cord-021424-kocwsyi7 260 19 by by IN cord-021424-kocwsyi7 260 20 bacterial bacterial JJ cord-021424-kocwsyi7 260 21 pathogens pathogen NNS cord-021424-kocwsyi7 261 1 pSTIING pSTIING NNP cord-021424-kocwsyi7 262 1 : : : cord-021424-kocwsyi7 263 1 A a DT cord-021424-kocwsyi7 263 2 " " `` cord-021424-kocwsyi7 263 3 systems system NNS cord-021424-kocwsyi7 263 4 " " '' cord-021424-kocwsyi7 263 5 approach approach NN cord-021424-kocwsyi7 263 6 towards towards IN cord-021424-kocwsyi7 263 7 integrating integrate VBG cord-021424-kocwsyi7 263 8 signalling signal VBG cord-021424-kocwsyi7 263 9 pathways pathway NNS cord-021424-kocwsyi7 263 10 , , , cord-021424-kocwsyi7 263 11 interaction interaction NN cord-021424-kocwsyi7 263 12 and and CC cord-021424-kocwsyi7 263 13 transcriptional transcriptional JJ cord-021424-kocwsyi7 263 14 regulatory regulatory JJ cord-021424-kocwsyi7 263 15 networks network NNS cord-021424-kocwsyi7 263 16 in in IN cord-021424-kocwsyi7 263 17 infl infl NN cord-021424-kocwsyi7 263 18 ammation ammation NN cord-021424-kocwsyi7 263 19 and and CC cord-021424-kocwsyi7 263 20 cancer cancer NN cord-021424-kocwsyi7 264 1 The the DT cord-021424-kocwsyi7 264 2 effect effect NN cord-021424-kocwsyi7 264 3 of of IN cord-021424-kocwsyi7 264 4 genetic genetic JJ cord-021424-kocwsyi7 264 5 variation variation NN cord-021424-kocwsyi7 264 6 in in IN cord-021424-kocwsyi7 264 7 chemokines chemokine NNS cord-021424-kocwsyi7 264 8 and and CC cord-021424-kocwsyi7 264 9 their -PRON- PRP$ cord-021424-kocwsyi7 264 10 receptors receptor NNS cord-021424-kocwsyi7 264 11 on on IN cord-021424-kocwsyi7 264 12 HIV HIV NNP cord-021424-kocwsyi7 264 13 transmission transmission NN cord-021424-kocwsyi7 264 14 and and CC cord-021424-kocwsyi7 264 15 progression progression NN cord-021424-kocwsyi7 264 16 to to IN cord-021424-kocwsyi7 264 17 AIDS AIDS NNP cord-021424-kocwsyi7 264 18 Connecting connect VBG cord-021424-kocwsyi7 264 19 mammalian mammalian JJ cord-021424-kocwsyi7 264 20 genome genome NN cord-021424-kocwsyi7 264 21 with with IN cord-021424-kocwsyi7 264 22 phenome phenome NNP cord-021424-kocwsyi7 264 23 by by IN cord-021424-kocwsyi7 264 24 ENU ENU NNP cord-021424-kocwsyi7 264 25 mouse mouse NN cord-021424-kocwsyi7 264 26 mutagenesis mutagenesis NN cord-021424-kocwsyi7 264 27 : : : cord-021424-kocwsyi7 264 28 Gene gene NN cord-021424-kocwsyi7 264 29 combinations combination NNS cord-021424-kocwsyi7 264 30 specifying specify VBG cord-021424-kocwsyi7 264 31 the the DT cord-021424-kocwsyi7 264 32 immune immune JJ cord-021424-kocwsyi7 264 33 system system NN cord-021424-kocwsyi7 264 34 Molecular molecular JJ cord-021424-kocwsyi7 264 35 diagnosis diagnosis NN cord-021424-kocwsyi7 264 36 of of IN cord-021424-kocwsyi7 264 37 inherited inherit VBN cord-021424-kocwsyi7 264 38 disorders disorder NNS cord-021424-kocwsyi7 264 39 : : : cord-021424-kocwsyi7 265 1 Lessons lesson NNS cord-021424-kocwsyi7 265 2 from from IN cord-021424-kocwsyi7 265 3 hemoglobinopathies hemoglobinopathy NNS cord-021424-kocwsyi7 265 4 Pyogenic Pyogenic NNP cord-021424-kocwsyi7 265 5 bacterial bacterial JJ cord-021424-kocwsyi7 265 6 infections infection NNS cord-021424-kocwsyi7 265 7 in in IN cord-021424-kocwsyi7 265 8 humans human NNS cord-021424-kocwsyi7 265 9 with with IN cord-021424-kocwsyi7 265 10 IRAK-4 IRAK-4 NNP cord-021424-kocwsyi7 265 11 defi defi NNP cord-021424-kocwsyi7 265 12 ciency ciency NNP cord-021424-kocwsyi7 265 13 Future future JJ cord-021424-kocwsyi7 265 14 trends trend NNS cord-021424-kocwsyi7 265 15 and and CC cord-021424-kocwsyi7 265 16 challenges challenge NNS cord-021424-kocwsyi7 265 17 in in IN cord-021424-kocwsyi7 265 18 pathogenomics pathogenomic NNS cord-021424-kocwsyi7 265 19 . . . cord-021424-kocwsyi7 266 1 A a DT cord-021424-kocwsyi7 266 2 Foresight Foresight NNP cord-021424-kocwsyi7 266 3 study study NN cord-021424-kocwsyi7 266 4 Microarray Microarray NNP cord-021424-kocwsyi7 266 5 data data NN cord-021424-kocwsyi7 266 6 normalization normalization NN cord-021424-kocwsyi7 266 7 and and CC cord-021424-kocwsyi7 266 8 transformation transformation NN cord-021424-kocwsyi7 266 9 Genomic genomic JJ cord-021424-kocwsyi7 266 10 signatures signature NNS cord-021424-kocwsyi7 266 11 of of IN cord-021424-kocwsyi7 266 12 immune immune NN cord-021424-kocwsyi7 266 13 and and CC cord-021424-kocwsyi7 266 14 infl infl NNP cord-021424-kocwsyi7 266 15 ammatory ammatory NNP cord-021424-kocwsyi7 266 16 responses response NNS cord-021424-kocwsyi7 267 1 Opinion opinion NN cord-021424-kocwsyi7 267 2 : : : cord-021424-kocwsyi7 268 1 Interpretation interpretation NN cord-021424-kocwsyi7 268 2 of of IN cord-021424-kocwsyi7 268 3 the the DT cord-021424-kocwsyi7 268 4 complexity complexity NN cord-021424-kocwsyi7 268 5 of of IN cord-021424-kocwsyi7 268 6 innate innate JJ cord-021424-kocwsyi7 268 7 immune immune JJ cord-021424-kocwsyi7 268 8 responses response NNS cord-021424-kocwsyi7 268 9 by by IN cord-021424-kocwsyi7 268 10 functional functional JJ cord-021424-kocwsyi7 268 11 genomics genomic NNS cord-021424-kocwsyi7 268 12 Congenic Congenic NNP cord-021424-kocwsyi7 268 13 mice mouse NNS cord-021424-kocwsyi7 268 14 : : : cord-021424-kocwsyi7 268 15 Cutting cut VBG cord-021424-kocwsyi7 268 16 tools tool NNS cord-021424-kocwsyi7 268 17 for for IN cord-021424-kocwsyi7 268 18 complex complex JJ cord-021424-kocwsyi7 268 19 immune immune JJ cord-021424-kocwsyi7 268 20 disorders disorder NNS cord-021424-kocwsyi7 269 1 Tumor tumor NN cord-021424-kocwsyi7 269 2 necrosis necrosis NN cord-021424-kocwsyi7 269 3 factor factor NN cord-021424-kocwsyi7 269 4 promoter promoter NN cord-021424-kocwsyi7 269 5 polymorphism polymorphism NN cord-021424-kocwsyi7 269 6 and and CC cord-021424-kocwsyi7 269 7 susceptibility susceptibility NN cord-021424-kocwsyi7 269 8 to to IN cord-021424-kocwsyi7 269 9 lepromatous lepromatous JJ cord-021424-kocwsyi7 269 10 leprosy leprosy NN cord-021424-kocwsyi7 269 11 Resistance Resistance NNP cord-021424-kocwsyi7 269 12 to to IN cord-021424-kocwsyi7 269 13 HIV-1 HIV-1 NNP cord-021424-kocwsyi7 269 14 infection infection NN cord-021424-kocwsyi7 269 15 in in IN cord-021424-kocwsyi7 269 16 caucasian caucasian JJ cord-021424-kocwsyi7 269 17 individuals individual NNS cord-021424-kocwsyi7 269 18 bearing bear VBG cord-021424-kocwsyi7 269 19 mutant mutant JJ cord-021424-kocwsyi7 269 20 alleles allele NNS cord-021424-kocwsyi7 269 21 of of IN cord-021424-kocwsyi7 269 22 the the DT cord-021424-kocwsyi7 269 23 CCR-5 ccr-5 JJ cord-021424-kocwsyi7 269 24 chemokine chemokine NN cord-021424-kocwsyi7 269 25 receptor receptor NN cord-021424-kocwsyi7 269 26 gene gene NN cord-021424-kocwsyi7 269 27 Genetics Genetics NNP cord-021424-kocwsyi7 269 28 of of IN cord-021424-kocwsyi7 269 29 gene gene NN cord-021424-kocwsyi7 269 30 expression expression NN cord-021424-kocwsyi7 269 31 surveyed survey VBN cord-021424-kocwsyi7 269 32 in in IN cord-021424-kocwsyi7 269 33 maize maize NN cord-021424-kocwsyi7 269 34 , , , cord-021424-kocwsyi7 269 35 mouse mouse NN cord-021424-kocwsyi7 269 36 and and CC cord-021424-kocwsyi7 269 37 man man NN cord-021424-kocwsyi7 269 38 Functional functional JJ cord-021424-kocwsyi7 269 39 and and CC cord-021424-kocwsyi7 269 40 comparative comparative JJ cord-021424-kocwsyi7 269 41 genomics genomic NNS cord-021424-kocwsyi7 269 42 of of IN cord-021424-kocwsyi7 269 43 pathogenic pathogenic JJ cord-021424-kocwsyi7 269 44 bacteria bacteria NNS cord-021424-kocwsyi7 269 45 Single single JJ cord-021424-kocwsyi7 269 46 nucleotide nucleotide JJ cord-021424-kocwsyi7 269 47 polymorphisms polymorphism NNS cord-021424-kocwsyi7 269 48 of of IN cord-021424-kocwsyi7 269 49 Toll toll NN cord-021424-kocwsyi7 269 50 - - HYPH cord-021424-kocwsyi7 269 51 like like JJ cord-021424-kocwsyi7 269 52 receptors receptor NNS cord-021424-kocwsyi7 269 53 and and CC cord-021424-kocwsyi7 269 54 susceptibility susceptibility NN cord-021424-kocwsyi7 269 55 to to IN cord-021424-kocwsyi7 269 56 infectious infectious JJ cord-021424-kocwsyi7 269 57 disease disease NN cord-021424-kocwsyi7 269 58 Mapping mapping NN cord-021424-kocwsyi7 269 59 of of IN cord-021424-kocwsyi7 269 60 genetic genetic JJ cord-021424-kocwsyi7 269 61 modulators modulator NNS cord-021424-kocwsyi7 269 62 of of IN cord-021424-kocwsyi7 269 63 natural natural JJ cord-021424-kocwsyi7 269 64 resistance resistance NN cord-021424-kocwsyi7 269 65 to to IN cord-021424-kocwsyi7 269 66 infection infection NN cord-021424-kocwsyi7 269 67 with with IN cord-021424-kocwsyi7 269 68 Salmonella Salmonella NNP cord-021424-kocwsyi7 269 69 typhimurium typhimurium NN cord-021424-kocwsyi7 269 70 in in IN cord-021424-kocwsyi7 269 71 wildderived wildderived NNP cord-021424-kocwsyi7 269 72 mice mice NNP cord-021424-kocwsyi7 269 73 Association Association NNP cord-021424-kocwsyi7 269 74 of of IN cord-021424-kocwsyi7 269 75 human human JJ cord-021424-kocwsyi7 269 76 leukocyte leukocyte NN cord-021424-kocwsyi7 269 77 antigen antigen NN cord-021424-kocwsyi7 269 78 - - : cord-021424-kocwsyi7 269 79 A11 A11 NNP cord-021424-kocwsyi7 269 80 with with IN cord-021424-kocwsyi7 269 81 resistance resistance NN cord-021424-kocwsyi7 269 82 and and CC cord-021424-kocwsyi7 269 83 B40 B40 NNP cord-021424-kocwsyi7 269 84 and and CC cord-021424-kocwsyi7 269 85 DR2 DR2 NNP cord-021424-kocwsyi7 269 86 with with IN cord-021424-kocwsyi7 269 87 susceptibility susceptibility NN cord-021424-kocwsyi7 269 88 to to IN cord-021424-kocwsyi7 269 89 HIV-1 HIV-1 NNP cord-021424-kocwsyi7 269 90 infection infection NN cord-021424-kocwsyi7 269 91 in in IN cord-021424-kocwsyi7 269 92 south south JJ cord-021424-kocwsyi7 269 93 India India NNP cord-021424-kocwsyi7 269 94 Resources Resources NNPS cord-021424-kocwsyi7 269 95 for for IN cord-021424-kocwsyi7 269 96 genetic genetic JJ cord-021424-kocwsyi7 269 97 variation variation NN cord-021424-kocwsyi7 269 98 studies studies NNPS cord-021424-kocwsyi7 269 99 Association Association NNP cord-021424-kocwsyi7 269 100 and and CC cord-021424-kocwsyi7 269 101 linkage linkage NN cord-021424-kocwsyi7 269 102 of of IN cord-021424-kocwsyi7 269 103 leprosy leprosy NN cord-021424-kocwsyi7 269 104 phenotypes phenotype NNS cord-021424-kocwsyi7 269 105 with with IN cord-021424-kocwsyi7 269 106 HLA HLA NNP cord-021424-kocwsyi7 269 107 class class NN cord-021424-kocwsyi7 269 108 II ii NN cord-021424-kocwsyi7 269 109 and and CC cord-021424-kocwsyi7 269 110 tumour tumour NN cord-021424-kocwsyi7 269 111 necrosis necrosis NN cord-021424-kocwsyi7 269 112 factor factor NN cord-021424-kocwsyi7 269 113 genes gene NNS cord-021424-kocwsyi7 269 114 Analysis Analysis NNP cord-021424-kocwsyi7 269 115 of of IN cord-021424-kocwsyi7 269 116 large large JJ cord-021424-kocwsyi7 269 117 - - HYPH cord-021424-kocwsyi7 269 118 scale scale NN cord-021424-kocwsyi7 269 119 gene gene NN cord-021424-kocwsyi7 269 120 expression expression NN cord-021424-kocwsyi7 269 121 data datum NNS cord-021424-kocwsyi7 269 122 Optimized optimize VBN cord-021424-kocwsyi7 269 123 blood blood NN cord-021424-kocwsyi7 269 124 cell cell NN cord-021424-kocwsyi7 269 125 profi profi NNP cord-021424-kocwsyi7 269 126 ling ling NNP cord-021424-kocwsyi7 269 127 method method NN cord-021424-kocwsyi7 269 128 for for IN cord-021424-kocwsyi7 269 129 genomic genomic JJ cord-021424-kocwsyi7 269 130 biomarker biomarker NN cord-021424-kocwsyi7 269 131 discovery discovery NN cord-021424-kocwsyi7 269 132 using use VBG cord-021424-kocwsyi7 269 133 high high JJ cord-021424-kocwsyi7 269 134 - - HYPH cord-021424-kocwsyi7 269 135 density density NN cord-021424-kocwsyi7 269 136 microarray microarray NN cord-021424-kocwsyi7 269 137 Dissecting dissect VBG cord-021424-kocwsyi7 269 138 innate innate JJ cord-021424-kocwsyi7 269 139 immune immune JJ cord-021424-kocwsyi7 269 140 responses response NNS cord-021424-kocwsyi7 269 141 with with IN cord-021424-kocwsyi7 269 142 the the DT cord-021424-kocwsyi7 269 143 tools tool NNS cord-021424-kocwsyi7 269 144 of of IN cord-021424-kocwsyi7 269 145 systems system NNS cord-021424-kocwsyi7 269 146 biology biology NN cord-021424-kocwsyi7 269 147 Genetic genetic JJ cord-021424-kocwsyi7 269 148 susceptibility susceptibility NN cord-021424-kocwsyi7 269 149 to to IN cord-021424-kocwsyi7 269 150 neonatal neonatal JJ cord-021424-kocwsyi7 269 151 infection infection NN cord-021424-kocwsyi7 269 152 Strong Strong NNP cord-021424-kocwsyi7 269 153 association association NN cord-021424-kocwsyi7 269 154 of of IN cord-021424-kocwsyi7 269 155 a a DT cord-021424-kocwsyi7 269 156 tumor tumor NN cord-021424-kocwsyi7 269 157 necrosis necrosis NN cord-021424-kocwsyi7 269 158 factor factor NN cord-021424-kocwsyi7 269 159 - - HYPH cord-021424-kocwsyi7 269 160 alpha alpha NN cord-021424-kocwsyi7 269 161 promoter promoter NN cord-021424-kocwsyi7 269 162 allele allele NN cord-021424-kocwsyi7 269 163 with with IN cord-021424-kocwsyi7 269 164 cerebral cerebral JJ cord-021424-kocwsyi7 269 165 malaria malaria NN cord-021424-kocwsyi7 269 166 in in IN cord-021424-kocwsyi7 269 167 Myanmar Myanmar NNP cord-021424-kocwsyi7 270 1 How how WRB cord-021424-kocwsyi7 270 2 many many JJ cord-021424-kocwsyi7 270 3 diseases disease NNS cord-021424-kocwsyi7 270 4 does do VBZ cord-021424-kocwsyi7 270 5 it -PRON- PRP cord-021424-kocwsyi7 270 6 take take VB cord-021424-kocwsyi7 270 7 to to TO cord-021424-kocwsyi7 270 8 map map VB cord-021424-kocwsyi7 270 9 a a DT cord-021424-kocwsyi7 270 10 gene gene NN cord-021424-kocwsyi7 270 11 with with IN cord-021424-kocwsyi7 270 12 SNPs snp NNS cord-021424-kocwsyi7 270 13 ? ? . cord-021424-kocwsyi7 271 1 Genetic genetic JJ cord-021424-kocwsyi7 271 2 control control NN cord-021424-kocwsyi7 271 3 of of IN cord-021424-kocwsyi7 271 4 the the DT cord-021424-kocwsyi7 271 5 innate innate JJ cord-021424-kocwsyi7 271 6 immune immune JJ cord-021424-kocwsyi7 271 7 response response NN cord-021424-kocwsyi7 271 8 Infl Infl NNP cord-021424-kocwsyi7 271 9 ammation ammation NN cord-021424-kocwsyi7 271 10 suppressor suppressor NN cord-021424-kocwsyi7 271 11 genes gene NNS cord-021424-kocwsyi7 271 12 : : : cord-021424-kocwsyi7 271 13 Please please UH cord-021424-kocwsyi7 271 14 switch switch VB cord-021424-kocwsyi7 271 15 out out RP cord-021424-kocwsyi7 271 16 all all PDT cord-021424-kocwsyi7 271 17 the the DT cord-021424-kocwsyi7 271 18 lights light NNS cord-021424-kocwsyi7 271 19 Identifi Identifi NNP cord-021424-kocwsyi7 271 20 cation cation NN cord-021424-kocwsyi7 271 21 of of IN cord-021424-kocwsyi7 271 22 high high JJ cord-021424-kocwsyi7 271 23 and and CC cord-021424-kocwsyi7 271 24 low low JJ cord-021424-kocwsyi7 271 25 responders responder NNS cord-021424-kocwsyi7 271 26 to to IN cord-021424-kocwsyi7 271 27 lipopolysaccharide lipopolysaccharide NN cord-021424-kocwsyi7 271 28 in in IN cord-021424-kocwsyi7 271 29 normal normal JJ cord-021424-kocwsyi7 271 30 subjects subject NNS cord-021424-kocwsyi7 271 31 : : : cord-021424-kocwsyi7 271 32 An an DT cord-021424-kocwsyi7 271 33 unbiased unbiased JJ cord-021424-kocwsyi7 271 34 approach approach NN cord-021424-kocwsyi7 271 35 to to TO cord-021424-kocwsyi7 271 36 identify identify VB cord-021424-kocwsyi7 271 37 modulators modulator NNS cord-021424-kocwsyi7 271 38 of of IN cord-021424-kocwsyi7 271 39 innate innate JJ cord-021424-kocwsyi7 271 40 immunity immunity NN cord-021424-kocwsyi7 271 41 Inverse inverse NN cord-021424-kocwsyi7 271 42 associations association NNS cord-021424-kocwsyi7 271 43 of of IN cord-021424-kocwsyi7 271 44 human human JJ cord-021424-kocwsyi7 271 45 leukocyte leukocyte NN cord-021424-kocwsyi7 271 46 antigen antigen NN cord-021424-kocwsyi7 271 47 and and CC cord-021424-kocwsyi7 271 48 malaria malaria NN cord-021424-kocwsyi7 271 49 parasite parasite NN cord-021424-kocwsyi7 271 50 types type NNS cord-021424-kocwsyi7 271 51 in in IN cord-021424-kocwsyi7 271 52 two two CD cord-021424-kocwsyi7 271 53 West west JJ cord-021424-kocwsyi7 271 54 African african JJ cord-021424-kocwsyi7 271 55 populations population NNS cord-021424-kocwsyi7 272 1 The the DT cord-021424-kocwsyi7 272 2 impact impact NN cord-021424-kocwsyi7 272 3 of of IN cord-021424-kocwsyi7 272 4 comparative comparative JJ cord-021424-kocwsyi7 272 5 genomics genomic NNS cord-021424-kocwsyi7 272 6 on on IN cord-021424-kocwsyi7 272 7 infectious infectious JJ cord-021424-kocwsyi7 272 8 disease disease NN cord-021424-kocwsyi7 272 9 research research NN cord-021424-kocwsyi7 272 10 Sensitive sensitive JJ cord-021424-kocwsyi7 272 11 and and CC cord-021424-kocwsyi7 272 12 quantitative quantitative JJ cord-021424-kocwsyi7 272 13 measurement measurement NN cord-021424-kocwsyi7 272 14 of of IN cord-021424-kocwsyi7 272 15 gene gene NN cord-021424-kocwsyi7 272 16 expression expression NN cord-021424-kocwsyi7 272 17 directly directly RB cord-021424-kocwsyi7 272 18 from from IN cord-021424-kocwsyi7 272 19 a a DT cord-021424-kocwsyi7 272 20 small small JJ cord-021424-kocwsyi7 272 21 amount amount NN cord-021424-kocwsyi7 272 22 of of IN cord-021424-kocwsyi7 272 23 whole whole JJ cord-021424-kocwsyi7 272 24 blood blood NN cord-021424-kocwsyi7 272 25 Jenner Jenner NNP cord-021424-kocwsyi7 272 26 , , , cord-021424-kocwsyi7 272 27 R.G. R.G. NNP cord-021424-kocwsyi7 272 28 , , , cord-021424-kocwsyi7 272 29 Young Young NNP cord-021424-kocwsyi7 272 30 , , , cord-021424-kocwsyi7 272 31 R.A. R.A. NNP cord-021424-kocwsyi7 272 32 ( ( -LRB- cord-021424-kocwsyi7 272 33 2005 2005 CD cord-021424-kocwsyi7 272 34 ) ) -RRB- cord-021424-kocwsyi7 272 35 . . . cord-021424-kocwsyi7 273 1 Insights insight NNS cord-021424-kocwsyi7 273 2 into into IN cord-021424-kocwsyi7 273 3 host host NN cord-021424-kocwsyi7 273 4 responses response NNS cord-021424-kocwsyi7 273 5 against against IN cord-021424-kocwsyi7 273 6 pathogens pathogen NNS cord-021424-kocwsyi7 273 7 from from IN cord-021424-kocwsyi7 273 8 transcriptional transcriptional JJ cord-021424-kocwsyi7 273 9 profi profi NNP cord-021424-kocwsyi7 273 10 ling ling NNP cord-021424-kocwsyi7 273 11 . . . cord-021424-kocwsyi7 274 1 Nat Nat NNP cord-021424-kocwsyi7 274 2 Rev Rev NNP cord-021424-kocwsyi7 274 3 Microbiol Microbiol NNP cord-021424-kocwsyi7 274 4 3(4 3(4 NNP cord-021424-kocwsyi7 274 5 ) ) -RRB- cord-021424-kocwsyi7 274 6 , , , cord-021424-kocwsyi7 274 7 281 281 CD cord-021424-kocwsyi7 274 8 - - SYM cord-021424-kocwsyi7 274 9 294 294 CD cord-021424-kocwsyi7 274 10 . . . cord-021424-kocwsyi7 275 1 This this DT cord-021424-kocwsyi7 275 2 review review NN cord-021424-kocwsyi7 275 3 describes describe VBZ cord-021424-kocwsyi7 275 4 a a DT cord-021424-kocwsyi7 275 5 meta meta JJ cord-021424-kocwsyi7 275 6 - - HYPH cord-021424-kocwsyi7 275 7 analysis analysis NN cord-021424-kocwsyi7 275 8 of of IN cord-021424-kocwsyi7 275 9 expression expression NN cord-021424-kocwsyi7 275 10 profi profi NNP cord-021424-kocwsyi7 275 11 ling ling NNP cord-021424-kocwsyi7 275 12 data datum NNS cord-021424-kocwsyi7 275 13 from from IN cord-021424-kocwsyi7 275 14 the the DT cord-021424-kocwsyi7 275 15 literature literature NN cord-021424-kocwsyi7 275 16 of of IN cord-021424-kocwsyi7 275 17 cells cell NNS cord-021424-kocwsyi7 275 18 infected infect VBN cord-021424-kocwsyi7 275 19 with with IN cord-021424-kocwsyi7 275 20 different different JJ cord-021424-kocwsyi7 275 21 pathogens pathogen NNS cord-021424-kocwsyi7 275 22 or or CC cord-021424-kocwsyi7 275 23 treated treat VBN cord-021424-kocwsyi7 275 24 with with IN cord-021424-kocwsyi7 275 25 pathogenic pathogenic JJ cord-021424-kocwsyi7 275 26 components component NNS cord-021424-kocwsyi7 275 27 . . . cord-021424-kocwsyi7 276 1 Lipoldova Lipoldova NNP cord-021424-kocwsyi7 276 2 , , , cord-021424-kocwsyi7 276 3 M. M. NNP cord-021424-kocwsyi7 276 4 , , , cord-021424-kocwsyi7 276 5 Demant Demant NNP cord-021424-kocwsyi7 276 6 , , , cord-021424-kocwsyi7 276 7 P. P. NNP cord-021424-kocwsyi7 276 8 ( ( -LRB- cord-021424-kocwsyi7 276 9 2006 2006 CD cord-021424-kocwsyi7 276 10 ) ) -RRB- cord-021424-kocwsyi7 276 11 . . . cord-021424-kocwsyi7 277 1 Genetic genetic JJ cord-021424-kocwsyi7 277 2 susceptibility susceptibility NN cord-021424-kocwsyi7 277 3 to to IN cord-021424-kocwsyi7 277 4 infectious infectious JJ cord-021424-kocwsyi7 277 5 disease disease NN cord-021424-kocwsyi7 277 6 : : : cord-021424-kocwsyi7 278 1 Lessons lesson NNS cord-021424-kocwsyi7 278 2 from from IN cord-021424-kocwsyi7 278 3 mouse mouse NN cord-021424-kocwsyi7 278 4 models model NNS cord-021424-kocwsyi7 278 5 of of IN cord-021424-kocwsyi7 278 6 leishmaniasis leishmaniasis NN cord-021424-kocwsyi7 278 7 . . . cord-021424-kocwsyi7 279 1 Nat Nat NNP cord-021424-kocwsyi7 279 2 Rev Rev NNP cord-021424-kocwsyi7 279 3 Genet Genet NNP cord-021424-kocwsyi7 279 4 7(4 7(4 NNP cord-021424-kocwsyi7 279 5 ) ) -RRB- cord-021424-kocwsyi7 279 6 , , , cord-021424-kocwsyi7 279 7 294 294 CD cord-021424-kocwsyi7 279 8 - - SYM cord-021424-kocwsyi7 279 9 305 305 CD cord-021424-kocwsyi7 279 10 . . . cord-021424-kocwsyi7 280 1 This this DT cord-021424-kocwsyi7 280 2 paper paper NN cord-021424-kocwsyi7 280 3 reviews review VBZ cord-021424-kocwsyi7 280 4 the the DT cord-021424-kocwsyi7 280 5 literature literature NN cord-021424-kocwsyi7 280 6 on on IN cord-021424-kocwsyi7 280 7 the the DT cord-021424-kocwsyi7 280 8 genetic genetic JJ cord-021424-kocwsyi7 280 9 susceptibility susceptibility NN cord-021424-kocwsyi7 280 10 to to IN cord-021424-kocwsyi7 280 11 infection infection NN cord-021424-kocwsyi7 280 12 with with IN cord-021424-kocwsyi7 280 13 Leishmania Leishmania NNP cord-021424-kocwsyi7 280 14 and and CC cord-021424-kocwsyi7 280 15 compares compare VBZ cord-021424-kocwsyi7 280 16 susceptibility susceptibility NN cord-021424-kocwsyi7 280 17 loci locus NNS cord-021424-kocwsyi7 280 18 to to IN cord-021424-kocwsyi7 280 19 those those DT cord-021424-kocwsyi7 280 20 identifi identifi NNS cord-021424-kocwsyi7 280 21 ed ed NN cord-021424-kocwsyi7 280 22 for for IN cord-021424-kocwsyi7 280 23 other other JJ cord-021424-kocwsyi7 280 24 infections infection NNS cord-021424-kocwsyi7 280 25 . . . cord-021424-kocwsyi7 281 1 Cook Cook NNP cord-021424-kocwsyi7 281 2 , , , cord-021424-kocwsyi7 281 3 D.N. D.N. NNP cord-021424-kocwsyi7 281 4 , , , cord-021424-kocwsyi7 281 5 Pisetsky Pisetsky NNP cord-021424-kocwsyi7 281 6 , , , cord-021424-kocwsyi7 281 7 D.S. D.S. NNP cord-021424-kocwsyi7 281 8 , , , cord-021424-kocwsyi7 281 9 Schwartz Schwartz NNP cord-021424-kocwsyi7 281 10 , , , cord-021424-kocwsyi7 281 11 D.A. D.A. NNP cord-021424-kocwsyi7 281 12 ( ( -LRB- cord-021424-kocwsyi7 281 13 2004 2004 CD cord-021424-kocwsyi7 281 14 ) ) -RRB- cord-021424-kocwsyi7 281 15 . . . cord-021424-kocwsyi7 282 1 Toll toll NN cord-021424-kocwsyi7 282 2 - - HYPH cord-021424-kocwsyi7 282 3 like like JJ cord-021424-kocwsyi7 282 4 receptors receptor NNS cord-021424-kocwsyi7 282 5 in in IN cord-021424-kocwsyi7 282 6 the the DT cord-021424-kocwsyi7 282 7 pathogenesis pathogenesis NN cord-021424-kocwsyi7 282 8 of of IN cord-021424-kocwsyi7 282 9 human human JJ cord-021424-kocwsyi7 282 10 disease disease NN cord-021424-kocwsyi7 282 11 . . . cord-021424-kocwsyi7 283 1 Nat Nat NNP cord-021424-kocwsyi7 283 2 Immunol Immunol NNP cord-021424-kocwsyi7 283 3 5(10 5(10 CD cord-021424-kocwsyi7 283 4 ) ) -RRB- cord-021424-kocwsyi7 283 5 , , , cord-021424-kocwsyi7 283 6 975 975 CD cord-021424-kocwsyi7 283 7 - - SYM cord-021424-kocwsyi7 283 8 979 979 CD cord-021424-kocwsyi7 283 9 . . . cord-021424-kocwsyi7 284 1 This this DT cord-021424-kocwsyi7 284 2 review review NN cord-021424-kocwsyi7 284 3 describes describe VBZ cord-021424-kocwsyi7 284 4 the the DT cord-021424-kocwsyi7 284 5 role role NN cord-021424-kocwsyi7 284 6 of of IN cord-021424-kocwsyi7 284 7 Toll Toll NNP cord-021424-kocwsyi7 284 8 - - HYPH cord-021424-kocwsyi7 284 9 like like JJ cord-021424-kocwsyi7 284 10 receptors receptor NNS cord-021424-kocwsyi7 284 11 in in IN cord-021424-kocwsyi7 284 12 detection detection NN cord-021424-kocwsyi7 284 13 of of IN cord-021424-kocwsyi7 284 14 pathogens pathogen NNS cord-021424-kocwsyi7 284 15 and and CC cord-021424-kocwsyi7 284 16 summarizes summarize VBZ cord-021424-kocwsyi7 284 17 their -PRON- PRP$ cord-021424-kocwsyi7 284 18 involvement involvement NN cord-021424-kocwsyi7 284 19 in in IN cord-021424-kocwsyi7 284 20 infectious infectious JJ cord-021424-kocwsyi7 284 21 disease disease NN cord-021424-kocwsyi7 284 22 susceptibility susceptibility NN cord-021424-kocwsyi7 284 23 . . . cord-021424-kocwsyi7 285 1 http://www.genmapp.org/ http://www.genmapp.org/ NNP cord-021424-kocwsyi7 285 2 Gene Gene NNP cord-021424-kocwsyi7 285 3 Map Map NNP cord-021424-kocwsyi7 285 4 Annotator Annotator NNP cord-021424-kocwsyi7 285 5 and and CC cord-021424-kocwsyi7 285 6 Pathway Pathway NNP cord-021424-kocwsyi7 285 7 Profi Profi NNP cord-021424-kocwsyi7 285 8 ler ler NNP cord-021424-kocwsyi7 285 9 is be VBZ cord-021424-kocwsyi7 285 10 a a DT cord-021424-kocwsyi7 285 11 computer computer NN cord-021424-kocwsyi7 285 12 application application NN cord-021424-kocwsyi7 285 13 designed design VBN cord-021424-kocwsyi7 285 14 to to TO cord-021424-kocwsyi7 285 15 visualize visualize VB cord-021424-kocwsyi7 285 16 gene gene NN cord-021424-kocwsyi7 285 17 expression expression NN cord-021424-kocwsyi7 285 18 data datum NNS cord-021424-kocwsyi7 285 19 on on IN cord-021424-kocwsyi7 285 20 maps map NNS cord-021424-kocwsyi7 285 21 representing represent VBG cord-021424-kocwsyi7 285 22 biological biological JJ cord-021424-kocwsyi7 285 23 pathways pathway NNS cord-021424-kocwsyi7 285 24 and and CC cord-021424-kocwsyi7 285 25 groupings grouping NNS cord-021424-kocwsyi7 285 26 of of IN cord-021424-kocwsyi7 285 27 genes gene NNS cord-021424-kocwsyi7 285 28 . . . cord-021424-kocwsyi7 286 1 http://www.ensembl.org/index.html http://www.ensembl.org/index.html NNP cord-021424-kocwsyi7 286 2 Ensembl Ensembl NNP cord-021424-kocwsyi7 286 3 is be VBZ cord-021424-kocwsyi7 286 4 a a DT cord-021424-kocwsyi7 286 5 joint joint JJ cord-021424-kocwsyi7 286 6 project project NN cord-021424-kocwsyi7 286 7 between between IN cord-021424-kocwsyi7 286 8 EMBL EMBL NNP cord-021424-kocwsyi7 286 9 - - HYPH cord-021424-kocwsyi7 286 10 EBI EBI NNP cord-021424-kocwsyi7 286 11 and and CC cord-021424-kocwsyi7 286 12 the the DT cord-021424-kocwsyi7 286 13 Sanger Sanger NNP cord-021424-kocwsyi7 286 14 Institute Institute NNP cord-021424-kocwsyi7 286 15 to to TO cord-021424-kocwsyi7 286 16 develop develop VB cord-021424-kocwsyi7 286 17 a a DT cord-021424-kocwsyi7 286 18 software software NN cord-021424-kocwsyi7 286 19 system system NN cord-021424-kocwsyi7 286 20 which which WDT cord-021424-kocwsyi7 286 21 produces produce VBZ cord-021424-kocwsyi7 286 22 and and CC cord-021424-kocwsyi7 286 23 maintains maintain VBZ cord-021424-kocwsyi7 286 24 automatic automatic JJ cord-021424-kocwsyi7 286 25 annotation annotation NN cord-021424-kocwsyi7 286 26 on on IN cord-021424-kocwsyi7 286 27 selected select VBN cord-021424-kocwsyi7 286 28 eukaryotic eukaryotic JJ cord-021424-kocwsyi7 286 29 genomes genome NNS cord-021424-kocwsyi7 286 30 . . . cord-021424-kocwsyi7 287 1 http://www.informatics.jax.org/ http://www.informatics.jax.org/ NNP cord-021424-kocwsyi7 287 2 MGD MGD NNP cord-021424-kocwsyi7 287 3 includes include VBZ cord-021424-kocwsyi7 287 4 information information NN cord-021424-kocwsyi7 287 5 on on IN cord-021424-kocwsyi7 287 6 mouse mouse NN cord-021424-kocwsyi7 287 7 genetic genetic JJ cord-021424-kocwsyi7 287 8 markers marker NNS cord-021424-kocwsyi7 287 9 , , , cord-021424-kocwsyi7 287 10 molecular molecular JJ cord-021424-kocwsyi7 287 11 clones clone NNS cord-021424-kocwsyi7 287 12 ( ( -LRB- cord-021424-kocwsyi7 287 13 probes probe NNS cord-021424-kocwsyi7 287 14 , , , cord-021424-kocwsyi7 287 15 primers primer NNS cord-021424-kocwsyi7 287 16 and and CC cord-021424-kocwsyi7 287 17 YACs YACs NNPS cord-021424-kocwsyi7 287 18 ) ) -RRB- cord-021424-kocwsyi7 287 19 , , , cord-021424-kocwsyi7 287 20 phenotypes phenotype NNS cord-021424-kocwsyi7 287 21 , , , cord-021424-kocwsyi7 287 22 sequences sequence NNS cord-021424-kocwsyi7 287 23 , , , cord-021424-kocwsyi7 287 24 comparative comparative JJ cord-021424-kocwsyi7 287 25 mapping mapping NN cord-021424-kocwsyi7 287 26 data datum NNS cord-021424-kocwsyi7 287 27 , , , cord-021424-kocwsyi7 287 28 graphical graphical JJ cord-021424-kocwsyi7 287 29 displays display NNS cord-021424-kocwsyi7 287 30 of of IN cord-021424-kocwsyi7 287 31 linkage linkage NN cord-021424-kocwsyi7 287 32 , , , cord-021424-kocwsyi7 287 33 cytogenetic cytogenetic JJ cord-021424-kocwsyi7 287 34 and and CC cord-021424-kocwsyi7 287 35 physical physical JJ cord-021424-kocwsyi7 287 36 maps map NNS cord-021424-kocwsyi7 287 37 , , , cord-021424-kocwsyi7 287 38 experimental experimental JJ cord-021424-kocwsyi7 287 39 mapping mapping NN cord-021424-kocwsyi7 287 40 data datum NNS cord-021424-kocwsyi7 287 41 , , , cord-021424-kocwsyi7 287 42 as as RB cord-021424-kocwsyi7 287 43 well well RB cord-021424-kocwsyi7 287 44 as as IN cord-021424-kocwsyi7 287 45 strain strain NN cord-021424-kocwsyi7 287 46 distribution distribution NN cord-021424-kocwsyi7 287 47 patterns pattern NNS cord-021424-kocwsyi7 287 48 for for IN cord-021424-kocwsyi7 287 49 recombinant recombinant JJ cord-021424-kocwsyi7 287 50 inbred inbred JJ cord-021424-kocwsyi7 287 51 strains strain NNS cord-021424-kocwsyi7 287 52 ( ( -LRB- cord-021424-kocwsyi7 287 53 RIs RIs NNP cord-021424-kocwsyi7 287 54 ) ) -RRB- cord-021424-kocwsyi7 287 55 and and CC cord-021424-kocwsyi7 287 56 cross cross NN cord-021424-kocwsyi7 287 57 haplotypes haplotype NNS cord-021424-kocwsyi7 287 58 . . . cord-021424-kocwsyi7 288 1 http://www.geneontology.org/ http://www.geneontology.org/ ADD cord-021424-kocwsyi7 288 2 The the DT cord-021424-kocwsyi7 288 3 Gene Gene NNP cord-021424-kocwsyi7 288 4 Ontology Ontology NNP cord-021424-kocwsyi7 288 5 project project NN cord-021424-kocwsyi7 288 6 provides provide VBZ cord-021424-kocwsyi7 288 7 a a DT cord-021424-kocwsyi7 288 8 controlled control VBN cord-021424-kocwsyi7 288 9 vocabulary vocabulary NN cord-021424-kocwsyi7 288 10 to to TO cord-021424-kocwsyi7 288 11 describe describe VB cord-021424-kocwsyi7 288 12 gene gene NN cord-021424-kocwsyi7 288 13 and and CC cord-021424-kocwsyi7 288 14 gene gene NN cord-021424-kocwsyi7 288 15 product product NN cord-021424-kocwsyi7 288 16 attributes attribute NNS cord-021424-kocwsyi7 288 17 in in IN cord-021424-kocwsyi7 288 18 any any DT cord-021424-kocwsyi7 288 19 organism organism NN cord-021424-kocwsyi7 288 20 . . . cord-021424-kocwsyi7 289 1 http://www.ncbi.nlm.nih.gov/geo/ http://www.ncbi.nlm.nih.gov/geo/ NNP cord-021424-kocwsyi7 289 2 Gene Gene NNP cord-021424-kocwsyi7 289 3 Expression Expression NNP cord-021424-kocwsyi7 289 4 Omnibus Omnibus NNP cord-021424-kocwsyi7 289 5 is be VBZ cord-021424-kocwsyi7 289 6 a a DT cord-021424-kocwsyi7 289 7 gene gene NN cord-021424-kocwsyi7 289 8 expression expression NN cord-021424-kocwsyi7 289 9 / / SYM cord-021424-kocwsyi7 289 10 molecular molecular JJ cord-021424-kocwsyi7 289 11 abundance abundance NN cord-021424-kocwsyi7 289 12 repository repository NN cord-021424-kocwsyi7 289 13 supporting support VBG cord-021424-kocwsyi7 289 14 MIAME MIAME NNP cord-021424-kocwsyi7 289 15 compliant compliant JJ cord-021424-kocwsyi7 289 16 microarray microarray NN cord-021424-kocwsyi7 289 17 data datum NNS cord-021424-kocwsyi7 289 18 submissions submission NNS cord-021424-kocwsyi7 289 19 , , , cord-021424-kocwsyi7 289 20 and and CC cord-021424-kocwsyi7 289 21 a a DT cord-021424-kocwsyi7 289 22 curated curate VBN cord-021424-kocwsyi7 289 23 , , , cord-021424-kocwsyi7 289 24 online online JJ cord-021424-kocwsyi7 289 25 resource resource NN cord-021424-kocwsyi7 289 26 for for IN cord-021424-kocwsyi7 289 27 gene gene NN cord-021424-kocwsyi7 289 28 expression expression NN cord-021424-kocwsyi7 289 29 data datum NNS cord-021424-kocwsyi7 289 30 browsing browsing NN cord-021424-kocwsyi7 289 31 , , , cord-021424-kocwsyi7 289 32 query query NN cord-021424-kocwsyi7 289 33 and and CC cord-021424-kocwsyi7 289 34 retrieval retrieval NN cord-021424-kocwsyi7 289 35 . . . cord-021424-kocwsyi7 290 1 http://www.genome-www5.stanford.edu/ http://www.genome-www5.stanford.edu/ NNP cord-021424-kocwsyi7 291 1 The the DT cord-021424-kocwsyi7 291 2 Stanford Stanford NNP cord-021424-kocwsyi7 291 3 MicroArray MicroArray NNP cord-021424-kocwsyi7 291 4 Database Database NNP cord-021424-kocwsyi7 291 5 stores store NNS cord-021424-kocwsyi7 291 6 raw raw JJ cord-021424-kocwsyi7 291 7 and and CC cord-021424-kocwsyi7 291 8 normalized normalized JJ cord-021424-kocwsyi7 291 9 data datum NNS cord-021424-kocwsyi7 291 10 from from IN cord-021424-kocwsyi7 291 11 microarray microarray NN cord-021424-kocwsyi7 291 12 experiments experiment NNS cord-021424-kocwsyi7 291 13 , , , cord-021424-kocwsyi7 291 14 and and CC cord-021424-kocwsyi7 291 15 provides provide VBZ cord-021424-kocwsyi7 291 16 data data NN cord-021424-kocwsyi7 291 17 retrieval retrieval NN cord-021424-kocwsyi7 291 18 , , , cord-021424-kocwsyi7 291 19 analysis analysis NN cord-021424-kocwsyi7 291 20 and and CC cord-021424-kocwsyi7 291 21 visualization visualization NN cord-021424-kocwsyi7 291 22 . . . cord-021424-kocwsyi7 292 1 http://www.expression.microslu.washington.edu/expression/index http://www.expression.microslu.washington.edu/expression/index JJ cord-021424-kocwsyi7 292 2 . . . cord-021424-kocwsyi7 293 1 html html NNP cord-021424-kocwsyi7 293 2 Public Public NNP cord-021424-kocwsyi7 293 3 Microarray Microarray NNP cord-021424-kocwsyi7 293 4 Data Data NNP cord-021424-kocwsyi7 293 5 Download Download NNP cord-021424-kocwsyi7 293 6 Site site NN cord-021424-kocwsyi7 293 7 powered power VBN cord-021424-kocwsyi7 293 8 by by IN cord-021424-kocwsyi7 293 9 Expres Expres NNP cord-021424-kocwsyi7 293 10 - - HYPH cord-021424-kocwsyi7 293 11 sion sion NNP cord-021424-kocwsyi7 293 12 Array Array NNP cord-021424-kocwsyi7 293 13 Manager Manager NNP cord-021424-kocwsyi7 293 14 . . . cord-021424-kocwsyi7 294 1 http://www.ncbi.nlm.nih.gov/projects/SNP/ http://www.ncbi.nlm.nih.gov/projects/snp/ CD cord-021424-kocwsyi7 295 1 The the DT cord-021424-kocwsyi7 295 2 National National NNP cord-021424-kocwsyi7 295 3 Center Center NNP cord-021424-kocwsyi7 295 4 for for IN cord-021424-kocwsyi7 295 5 Biotechnology Biotechnology NNP cord-021424-kocwsyi7 295 6 Information Information NNP cord-021424-kocwsyi7 295 7 has have VBZ cord-021424-kocwsyi7 295 8 established establish VBN cord-021424-kocwsyi7 295 9 the the DT cord-021424-kocwsyi7 295 10 Single Single NNP cord-021424-kocwsyi7 295 11 Nucleotide Nucleotide NNP cord-021424-kocwsyi7 295 12 Polymorphism Polymorphism NNP cord-021424-kocwsyi7 295 13 ( ( -LRB- cord-021424-kocwsyi7 295 14 dbSNP dbSNP NNP cord-021424-kocwsyi7 295 15 ) ) -RRB- cord-021424-kocwsyi7 295 16 database database NN cord-021424-kocwsyi7 295 17 to to TO cord-021424-kocwsyi7 295 18 serve serve VB cord-021424-kocwsyi7 295 19 as as IN cord-021424-kocwsyi7 295 20 a a DT cord-021424-kocwsyi7 295 21 central central JJ cord-021424-kocwsyi7 295 22 repository repository NN cord-021424-kocwsyi7 295 23 for for IN cord-021424-kocwsyi7 295 24 both both DT cord-021424-kocwsyi7 295 25 single single JJ cord-021424-kocwsyi7 295 26 base base NN cord-021424-kocwsyi7 295 27 nucleotide nucleotide NN cord-021424-kocwsyi7 295 28 substitutions substitution NNS cord-021424-kocwsyi7 295 29 and and CC cord-021424-kocwsyi7 295 30 short short JJ cord-021424-kocwsyi7 295 31 deletion deletion NN cord-021424-kocwsyi7 295 32 and and CC cord-021424-kocwsyi7 295 33 insertion insertion NN cord-021424-kocwsyi7 295 34 polymorphisms polymorphism NNS cord-021424-kocwsyi7 295 35 . . . cord-021424-kocwsyi7 296 1 Recommended Recommended NNP cord-021424-kocwsyi7 296 2 Resources Resources NNP cord-021424-kocwsyi7 296 3 ■ ■ NFP cord-021424-kocwsyi7 296 4 1323 1323 CD