id sid tid token lemma pos cord-021413-1ht1xm88 1 1 key key JJ cord-021413-1ht1xm88 1 2 : : : cord-021413-1ht1xm88 1 3 cord-021413 cord-021413 VB cord-021413-1ht1xm88 1 4 - - HYPH cord-021413-1ht1xm88 1 5 1ht1xm88 1ht1xm88 CD cord-021413-1ht1xm88 1 6 authors author NNS cord-021413-1ht1xm88 1 7 : : : cord-021413-1ht1xm88 1 8 Kraft Kraft NNP cord-021413-1ht1xm88 1 9 , , , cord-021413-1ht1xm88 1 10 Lisbeth Lisbeth NNP cord-021413-1ht1xm88 1 11 M. M. NNP cord-021413-1ht1xm88 1 12 title title NN cord-021413-1ht1xm88 1 13 : : : cord-021413-1ht1xm88 1 14 Viral Viral NNP cord-021413-1ht1xm88 1 15 Diseases disease NNS cord-021413-1ht1xm88 1 16 of of IN cord-021413-1ht1xm88 1 17 the the DT cord-021413-1ht1xm88 1 18 Digestive Digestive NNP cord-021413-1ht1xm88 1 19 System System NNP cord-021413-1ht1xm88 1 20 date date NN cord-021413-1ht1xm88 1 21 : : : cord-021413-1ht1xm88 1 22 2013 2013 CD cord-021413-1ht1xm88 1 23 - - SYM cord-021413-1ht1xm88 1 24 10 10 CD cord-021413-1ht1xm88 1 25 - - SYM cord-021413-1ht1xm88 1 26 21 21 CD cord-021413-1ht1xm88 1 27 journal journal NN cord-021413-1ht1xm88 1 28 : : : cord-021413-1ht1xm88 2 1 Diseases disease NNS cord-021413-1ht1xm88 2 2 DOI DOI NNP cord-021413-1ht1xm88 2 3 : : : cord-021413-1ht1xm88 2 4 10.1016 10.1016 CD cord-021413-1ht1xm88 3 1 /b978 /b978 , cord-021413-1ht1xm88 3 2 - - HYPH cord-021413-1ht1xm88 3 3 0 0 CD cord-021413-1ht1xm88 3 4 - - HYPH cord-021413-1ht1xm88 3 5 12 12 CD cord-021413-1ht1xm88 3 6 - - HYPH cord-021413-1ht1xm88 3 7 262502 262502 CD cord-021413-1ht1xm88 3 8 - - HYPH cord-021413-1ht1xm88 3 9 2.50016-x 2.50016-x CD cord-021413-1ht1xm88 3 10 sha sha NN cord-021413-1ht1xm88 3 11 : : : cord-021413-1ht1xm88 3 12 e6c3d3aa809ba36ce0828edcfb83cc3aa3397fc7 e6c3d3aa809ba36ce0828edcfb83cc3aa3397fc7 NNP cord-021413-1ht1xm88 3 13 doc_id doc_id CD cord-021413-1ht1xm88 3 14 : : : cord-021413-1ht1xm88 3 15 21413 21413 CD cord-021413-1ht1xm88 3 16 cord_uid cord_uid NNS cord-021413-1ht1xm88 3 17 : : : cord-021413-1ht1xm88 3 18 1ht1xm88 1ht1xm88 CD cord-021413-1ht1xm88 4 1 This this DT cord-021413-1ht1xm88 4 2 chapter chapter NN cord-021413-1ht1xm88 4 3 discusses discuss VBZ cord-021413-1ht1xm88 4 4 three three CD cord-021413-1ht1xm88 4 5 virus virus NN cord-021413-1ht1xm88 4 6 infections infection NNS cord-021413-1ht1xm88 4 7 affecting affect VBG cord-021413-1ht1xm88 4 8 the the DT cord-021413-1ht1xm88 4 9 digestive digestive JJ cord-021413-1ht1xm88 4 10 system system NN cord-021413-1ht1xm88 4 11 of of IN cord-021413-1ht1xm88 4 12 mice mouse NNS cord-021413-1ht1xm88 4 13 and and CC cord-021413-1ht1xm88 4 14 their -PRON- PRP$ cord-021413-1ht1xm88 4 15 properties property NNS cord-021413-1ht1xm88 4 16 : : : cord-021413-1ht1xm88 4 17 ( ( -LRB- cord-021413-1ht1xm88 4 18 1 1 LS cord-021413-1ht1xm88 4 19 ) ) -RRB- cord-021413-1ht1xm88 4 20 epizootic epizootic JJ cord-021413-1ht1xm88 4 21 diarrhea diarrhea NN cord-021413-1ht1xm88 4 22 of of IN cord-021413-1ht1xm88 4 23 infant infant NN cord-021413-1ht1xm88 4 24 mice mouse NNS cord-021413-1ht1xm88 4 25 ( ( -LRB- cord-021413-1ht1xm88 4 26 EDIM EDIM NNP cord-021413-1ht1xm88 4 27 ) ) -RRB- cord-021413-1ht1xm88 4 28 , , , cord-021413-1ht1xm88 4 29 ( ( -LRB- cord-021413-1ht1xm88 4 30 2 2 LS cord-021413-1ht1xm88 4 31 ) ) -RRB- cord-021413-1ht1xm88 4 32 reovirus reovirus VBP cord-021413-1ht1xm88 4 33 3 3 CD cord-021413-1ht1xm88 4 34 infection infection NN cord-021413-1ht1xm88 4 35 , , , cord-021413-1ht1xm88 4 36 and and CC cord-021413-1ht1xm88 4 37 ( ( -LRB- cord-021413-1ht1xm88 4 38 3 3 LS cord-021413-1ht1xm88 4 39 ) ) -RRB- cord-021413-1ht1xm88 4 40 murine murine JJ cord-021413-1ht1xm88 4 41 hepatitis hepatitis NN cord-021413-1ht1xm88 4 42 virus virus NN cord-021413-1ht1xm88 4 43 infection infection NN cord-021413-1ht1xm88 4 44 ( ( -LRB- cord-021413-1ht1xm88 4 45 MHV MHV NNP cord-021413-1ht1xm88 4 46 ) ) -RRB- cord-021413-1ht1xm88 4 47 . . . cord-021413-1ht1xm88 5 1 All all DT cord-021413-1ht1xm88 5 2 three three CD cord-021413-1ht1xm88 5 3 infections infection NNS cord-021413-1ht1xm88 5 4 may may MD cord-021413-1ht1xm88 5 5 cause cause VB cord-021413-1ht1xm88 5 6 serious serious JJ cord-021413-1ht1xm88 5 7 , , , cord-021413-1ht1xm88 5 8 debilitating debilitating JJ cord-021413-1ht1xm88 5 9 , , , cord-021413-1ht1xm88 5 10 and and CC cord-021413-1ht1xm88 5 11 sometimes sometimes RB cord-021413-1ht1xm88 5 12 fatal fatal JJ cord-021413-1ht1xm88 5 13 diarrheal diarrheal JJ cord-021413-1ht1xm88 5 14 disease disease NN cord-021413-1ht1xm88 5 15 in in IN cord-021413-1ht1xm88 5 16 nursling nursling NN cord-021413-1ht1xm88 5 17 and and CC cord-021413-1ht1xm88 5 18 weanling weanle VBG cord-021413-1ht1xm88 5 19 mice mouse NNS cord-021413-1ht1xm88 5 20 . . . cord-021413-1ht1xm88 6 1 Mice mouse NNS cord-021413-1ht1xm88 6 2 of of IN cord-021413-1ht1xm88 6 3 all all DT cord-021413-1ht1xm88 6 4 ages age NNS cord-021413-1ht1xm88 6 5 can can MD cord-021413-1ht1xm88 6 6 be be VB cord-021413-1ht1xm88 6 7 infected infect VBN cord-021413-1ht1xm88 6 8 by by IN cord-021413-1ht1xm88 6 9 the the DT cord-021413-1ht1xm88 6 10 EDIM EDIM NNP cord-021413-1ht1xm88 6 11 virus virus NN cord-021413-1ht1xm88 6 12 but but CC cord-021413-1ht1xm88 6 13 overt overt JJ cord-021413-1ht1xm88 6 14 disease disease NN cord-021413-1ht1xm88 6 15 is be VBZ cord-021413-1ht1xm88 6 16 restricted restrict VBN cord-021413-1ht1xm88 6 17 to to IN cord-021413-1ht1xm88 6 18 animals animal NNS cord-021413-1ht1xm88 6 19 up up IN cord-021413-1ht1xm88 6 20 to to IN cord-021413-1ht1xm88 6 21 about about RB cord-021413-1ht1xm88 6 22 12–13 12–13 JJ cord-021413-1ht1xm88 6 23 days day NNS cord-021413-1ht1xm88 6 24 of of IN cord-021413-1ht1xm88 6 25 age age NN cord-021413-1ht1xm88 6 26 at at IN cord-021413-1ht1xm88 6 27 the the DT cord-021413-1ht1xm88 6 28 time time NN cord-021413-1ht1xm88 6 29 of of IN cord-021413-1ht1xm88 6 30 first first JJ cord-021413-1ht1xm88 6 31 exposure exposure NN cord-021413-1ht1xm88 6 32 . . . cord-021413-1ht1xm88 7 1 The the DT cord-021413-1ht1xm88 7 2 EDIM EDIM NNP cord-021413-1ht1xm88 7 3 virus virus NN cord-021413-1ht1xm88 7 4 is be VBZ cord-021413-1ht1xm88 7 5 worldwide worldwide RB cord-021413-1ht1xm88 7 6 in in IN cord-021413-1ht1xm88 7 7 distribution distribution NN cord-021413-1ht1xm88 7 8 . . . cord-021413-1ht1xm88 8 1 Its -PRON- PRP$ cord-021413-1ht1xm88 8 2 prevalence prevalence NN cord-021413-1ht1xm88 8 3 is be VBZ cord-021413-1ht1xm88 8 4 difficult difficult JJ cord-021413-1ht1xm88 8 5 to to TO cord-021413-1ht1xm88 8 6 estimate estimate VB cord-021413-1ht1xm88 8 7 because because IN cord-021413-1ht1xm88 8 8 serologic serologic NNP cord-021413-1ht1xm88 8 9 tests test NNS cord-021413-1ht1xm88 8 10 have have VBP cord-021413-1ht1xm88 8 11 not not RB cord-021413-1ht1xm88 8 12 been be VBN cord-021413-1ht1xm88 8 13 readily readily RB cord-021413-1ht1xm88 8 14 available available JJ cord-021413-1ht1xm88 8 15 , , , cord-021413-1ht1xm88 8 16 and and CC cord-021413-1ht1xm88 8 17 it -PRON- PRP cord-021413-1ht1xm88 8 18 is be VBZ cord-021413-1ht1xm88 8 19 not not RB cord-021413-1ht1xm88 8 20 customary customary JJ cord-021413-1ht1xm88 8 21 to to TO cord-021413-1ht1xm88 8 22 sacrifice sacrifice VB cord-021413-1ht1xm88 8 23 animals animal NNS cord-021413-1ht1xm88 8 24 for for IN cord-021413-1ht1xm88 8 25 the the DT cord-021413-1ht1xm88 8 26 purpose purpose NN cord-021413-1ht1xm88 8 27 of of IN cord-021413-1ht1xm88 8 28 examining examine VBG cord-021413-1ht1xm88 8 29 the the DT cord-021413-1ht1xm88 8 30 appearance appearance NN cord-021413-1ht1xm88 8 31 of of IN cord-021413-1ht1xm88 8 32 their -PRON- PRP$ cord-021413-1ht1xm88 8 33 intestinal intestinal JJ cord-021413-1ht1xm88 8 34 tract tract NN cord-021413-1ht1xm88 8 35 or or CC cord-021413-1ht1xm88 8 36 for for IN cord-021413-1ht1xm88 8 37 electron electron NN cord-021413-1ht1xm88 8 38 microscopic microscopic JJ cord-021413-1ht1xm88 8 39 visualization visualization NN cord-021413-1ht1xm88 8 40 of of IN cord-021413-1ht1xm88 8 41 fecal fecal JJ cord-021413-1ht1xm88 8 42 contents content NNS cord-021413-1ht1xm88 8 43 . . . cord-021413-1ht1xm88 9 1 The the DT cord-021413-1ht1xm88 9 2 acute acute JJ cord-021413-1ht1xm88 9 3 disease disease NN cord-021413-1ht1xm88 9 4 of of IN cord-021413-1ht1xm88 9 5 reovirus reovirus NNP cord-021413-1ht1xm88 9 6 3 3 CD cord-021413-1ht1xm88 9 7 infection infection NN cord-021413-1ht1xm88 9 8 affects affect VBZ cord-021413-1ht1xm88 9 9 mainly mainly RB cord-021413-1ht1xm88 9 10 sucklings suckling NNS cord-021413-1ht1xm88 9 11 and and CC cord-021413-1ht1xm88 9 12 weanlings weanling NNS cord-021413-1ht1xm88 9 13 , , , cord-021413-1ht1xm88 9 14 whereas whereas IN cord-021413-1ht1xm88 9 15 the the DT cord-021413-1ht1xm88 9 16 chronic chronic JJ cord-021413-1ht1xm88 9 17 disease disease NN cord-021413-1ht1xm88 9 18 is be VBZ cord-021413-1ht1xm88 9 19 encountered encounter VBN cord-021413-1ht1xm88 9 20 in in IN cord-021413-1ht1xm88 9 21 animals animal NNS cord-021413-1ht1xm88 9 22 over over IN cord-021413-1ht1xm88 9 23 28 28 CD cord-021413-1ht1xm88 9 24 days day NNS cord-021413-1ht1xm88 9 25 of of IN cord-021413-1ht1xm88 9 26 age age NN cord-021413-1ht1xm88 9 27 . . . cord-021413-1ht1xm88 10 1 The the DT cord-021413-1ht1xm88 10 2 MHV MHV NNP cord-021413-1ht1xm88 10 3 virus virus NN cord-021413-1ht1xm88 10 4 , , , cord-021413-1ht1xm88 10 5 on on IN cord-021413-1ht1xm88 10 6 the the DT cord-021413-1ht1xm88 10 7 other other JJ cord-021413-1ht1xm88 10 8 hand hand NN cord-021413-1ht1xm88 10 9 , , , cord-021413-1ht1xm88 10 10 has have VBZ cord-021413-1ht1xm88 10 11 been be VBN cord-021413-1ht1xm88 10 12 found find VBN cord-021413-1ht1xm88 10 13 to to TO cord-021413-1ht1xm88 10 14 affect affect VB cord-021413-1ht1xm88 10 15 cotton cotton NN cord-021413-1ht1xm88 10 16 rats rat NNS cord-021413-1ht1xm88 10 17 , , , cord-021413-1ht1xm88 10 18 rats rat NNS cord-021413-1ht1xm88 10 19 , , , cord-021413-1ht1xm88 10 20 and and CC cord-021413-1ht1xm88 10 21 hamsters hamster NNS cord-021413-1ht1xm88 10 22 . . . cord-021413-1ht1xm88 11 1 epidemic epidemic JJ cord-021413-1ht1xm88 11 2 diarrhea diarrhea NN cord-021413-1ht1xm88 11 3 of of IN cord-021413-1ht1xm88 11 4 infant infant NN cord-021413-1ht1xm88 11 5 mice mouse NNS cord-021413-1ht1xm88 11 6 , , , cord-021413-1ht1xm88 11 7 it -PRON- PRP cord-021413-1ht1xm88 11 8 is be VBZ cord-021413-1ht1xm88 11 9 common common JJ cord-021413-1ht1xm88 11 10 knowledge knowledge NN cord-021413-1ht1xm88 11 11 that that WDT cord-021413-1ht1xm88 11 12 virtually virtually RB cord-021413-1ht1xm88 11 13 every every DT cord-021413-1ht1xm88 11 14 colony colony NN cord-021413-1ht1xm88 11 15 of of IN cord-021413-1ht1xm88 11 16 conventional conventional JJ cord-021413-1ht1xm88 11 17 mice mouse NNS cord-021413-1ht1xm88 11 18 suffered suffer VBD cord-021413-1ht1xm88 11 19 that that IN cord-021413-1ht1xm88 11 20 infec infec IN cord-021413-1ht1xm88 11 21 tion tion NN cord-021413-1ht1xm88 11 22 to to IN cord-021413-1ht1xm88 11 23 a a DT cord-021413-1ht1xm88 11 24 greater great JJR cord-021413-1ht1xm88 11 25 or or CC cord-021413-1ht1xm88 11 26 lesser less JJR cord-021413-1ht1xm88 11 27 extent extent NN cord-021413-1ht1xm88 11 28 . . . cord-021413-1ht1xm88 12 1 In in IN cord-021413-1ht1xm88 12 2 recent recent JJ cord-021413-1ht1xm88 12 3 years year NNS cord-021413-1ht1xm88 12 4 , , , cord-021413-1ht1xm88 12 5 with with IN cord-021413-1ht1xm88 12 6 the the DT cord-021413-1ht1xm88 12 7 advent advent NN cord-021413-1ht1xm88 12 8 of of IN cord-021413-1ht1xm88 12 9 measures measure NNS cord-021413-1ht1xm88 12 10 such such JJ cord-021413-1ht1xm88 12 11 as as IN cord-021413-1ht1xm88 12 12 cesa cesa NNP cord-021413-1ht1xm88 12 13 rean rean NNP cord-021413-1ht1xm88 12 14 derivation derivation NN cord-021413-1ht1xm88 12 15 , , , cord-021413-1ht1xm88 12 16 barrier barrier NN cord-021413-1ht1xm88 12 17 - - HYPH cord-021413-1ht1xm88 12 18 sustained sustain VBN cord-021413-1ht1xm88 12 19 breeding breeding NN cord-021413-1ht1xm88 12 20 and and CC cord-021413-1ht1xm88 12 21 maintenance maintenance NN cord-021413-1ht1xm88 12 22 procedures procedure NNS cord-021413-1ht1xm88 12 23 , , , cord-021413-1ht1xm88 12 24 routine routine JJ cord-021413-1ht1xm88 12 25 serologic serologic NN cord-021413-1ht1xm88 12 26 surveillance surveillance NN cord-021413-1ht1xm88 12 27 , , , cord-021413-1ht1xm88 12 28 laminar laminar JJ cord-021413-1ht1xm88 12 29 flow flow NN cord-021413-1ht1xm88 12 30 hoods hood NNS cord-021413-1ht1xm88 12 31 or or CC cord-021413-1ht1xm88 12 32 rooms room NNS cord-021413-1ht1xm88 12 33 , , , cord-021413-1ht1xm88 12 34 and and CC cord-021413-1ht1xm88 12 35 filter filter NN cord-021413-1ht1xm88 12 36 - - HYPH cord-021413-1ht1xm88 12 37 top top NN cord-021413-1ht1xm88 12 38 cages cage NNS cord-021413-1ht1xm88 12 39 , , , cord-021413-1ht1xm88 12 40 the the DT cord-021413-1ht1xm88 12 41 problems problem NNS cord-021413-1ht1xm88 12 42 associated associate VBN cord-021413-1ht1xm88 12 43 with with IN cord-021413-1ht1xm88 12 44 these these DT cord-021413-1ht1xm88 12 45 diseases disease NNS cord-021413-1ht1xm88 12 46 have have VBP cord-021413-1ht1xm88 12 47 become become VBN cord-021413-1ht1xm88 12 48 somewhat somewhat RB cord-021413-1ht1xm88 12 49 less less RBR cord-021413-1ht1xm88 12 50 critical critical JJ cord-021413-1ht1xm88 12 51 . . . cord-021413-1ht1xm88 13 1 Neverthe Neverthe NNP cord-021413-1ht1xm88 13 2 less less RBR cord-021413-1ht1xm88 13 3 , , , cord-021413-1ht1xm88 13 4 they -PRON- PRP cord-021413-1ht1xm88 13 5 are be VBP cord-021413-1ht1xm88 13 6 at at IN cord-021413-1ht1xm88 13 7 times time NNS cord-021413-1ht1xm88 13 8 and and CC cord-021413-1ht1xm88 13 9 under under IN cord-021413-1ht1xm88 13 10 certain certain JJ cord-021413-1ht1xm88 13 11 circumstances circumstance NNS cord-021413-1ht1xm88 13 12 still still RB cord-021413-1ht1xm88 13 13 troublesome troublesome JJ cord-021413-1ht1xm88 13 14 . . . cord-021413-1ht1xm88 14 1 All all DT cord-021413-1ht1xm88 14 2 three three CD cord-021413-1ht1xm88 14 3 infections infection NNS cord-021413-1ht1xm88 14 4 may may MD cord-021413-1ht1xm88 14 5 cause cause VB cord-021413-1ht1xm88 14 6 serious serious JJ cord-021413-1ht1xm88 14 7 , , , cord-021413-1ht1xm88 14 8 debilitating debilitating JJ cord-021413-1ht1xm88 14 9 , , , cord-021413-1ht1xm88 14 10 and and CC cord-021413-1ht1xm88 14 11 sometimes sometimes RB cord-021413-1ht1xm88 14 12 fatal fatal JJ cord-021413-1ht1xm88 14 13 diarrheal diarrheal JJ cord-021413-1ht1xm88 14 14 disease disease NN cord-021413-1ht1xm88 14 15 in in IN cord-021413-1ht1xm88 14 16 nursling nursling NN cord-021413-1ht1xm88 14 17 and and CC cord-021413-1ht1xm88 14 18 weanling weanle VBG cord-021413-1ht1xm88 14 19 mice mouse NNS cord-021413-1ht1xm88 14 20 . . . cord-021413-1ht1xm88 15 1 Thus thus RB cord-021413-1ht1xm88 15 2 , , , cord-021413-1ht1xm88 15 3 the the DT cord-021413-1ht1xm88 15 4 economic economic JJ cord-021413-1ht1xm88 15 5 impact impact NN cord-021413-1ht1xm88 15 6 on on IN cord-021413-1ht1xm88 15 7 commercial commercial JJ cord-021413-1ht1xm88 15 8 mouse mouse NN cord-021413-1ht1xm88 15 9 col col NNP cord-021413-1ht1xm88 15 10 onies onies NNP cord-021413-1ht1xm88 15 11 can can MD cord-021413-1ht1xm88 15 12 be be VB cord-021413-1ht1xm88 15 13 severe severe JJ cord-021413-1ht1xm88 15 14 . . . cord-021413-1ht1xm88 16 1 Furthermore furthermore RB cord-021413-1ht1xm88 16 2 , , , cord-021413-1ht1xm88 16 3 newborn newborn JJ cord-021413-1ht1xm88 16 4 mice mouse NNS cord-021413-1ht1xm88 16 5 , , , cord-021413-1ht1xm88 16 6 pooled pool VBN cord-021413-1ht1xm88 16 7 from from IN cord-021413-1ht1xm88 16 8 many many JJ cord-021413-1ht1xm88 16 9 dams dam NNS cord-021413-1ht1xm88 16 10 and and CC cord-021413-1ht1xm88 16 11 then then RB cord-021413-1ht1xm88 16 12 redistributed redistribute VBD cord-021413-1ht1xm88 16 13 to to IN cord-021413-1ht1xm88 16 14 them -PRON- PRP cord-021413-1ht1xm88 16 15 at at IN cord-021413-1ht1xm88 16 16 random random JJ cord-021413-1ht1xm88 16 17 , , , cord-021413-1ht1xm88 16 18 are be VBP cord-021413-1ht1xm88 16 19 used use VBN cord-021413-1ht1xm88 16 20 for for IN cord-021413-1ht1xm88 16 21 the the DT cord-021413-1ht1xm88 16 22 isolation isolation NN cord-021413-1ht1xm88 16 23 and and CC cord-021413-1ht1xm88 16 24 identification identification NN cord-021413-1ht1xm88 16 25 of of IN cord-021413-1ht1xm88 16 26 certain certain JJ cord-021413-1ht1xm88 16 27 viruses virus NNS cord-021413-1ht1xm88 16 28 in in IN cord-021413-1ht1xm88 16 29 diagnos diagnos NNP cord-021413-1ht1xm88 16 30 tic tic NNP cord-021413-1ht1xm88 16 31 and and CC cord-021413-1ht1xm88 16 32 epidemiological epidemiological JJ cord-021413-1ht1xm88 16 33 studies study NNS cord-021413-1ht1xm88 16 34 , , , cord-021413-1ht1xm88 16 35 for for IN cord-021413-1ht1xm88 16 36 example example NN cord-021413-1ht1xm88 16 37 arboviruses arbovirus NNS cord-021413-1ht1xm88 16 38 ( ( -LRB- cord-021413-1ht1xm88 16 39 Shope Shope NNP cord-021413-1ht1xm88 16 40 , , , cord-021413-1ht1xm88 16 41 1980 1980 CD cord-021413-1ht1xm88 16 42 ) ) -RRB- cord-021413-1ht1xm88 16 43 , , , cord-021413-1ht1xm88 16 44 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 16 45 , , , cord-021413-1ht1xm88 16 46 and and CC cord-021413-1ht1xm88 16 47 reoviruses reoviruses NNP cord-021413-1ht1xm88 16 48 ( ( -LRB- cord-021413-1ht1xm88 16 49 Stanley Stanley NNP cord-021413-1ht1xm88 16 50 , , , cord-021413-1ht1xm88 16 51 1977 1977 CD cord-021413-1ht1xm88 16 52 ) ) -RRB- cord-021413-1ht1xm88 16 53 . . . cord-021413-1ht1xm88 17 1 Clearly clearly RB cord-021413-1ht1xm88 17 2 , , , cord-021413-1ht1xm88 17 3 indigenous indigenous JJ cord-021413-1ht1xm88 17 4 infection infection NN cord-021413-1ht1xm88 17 5 with with IN cord-021413-1ht1xm88 17 6 related related JJ cord-021413-1ht1xm88 17 7 or or CC cord-021413-1ht1xm88 17 8 identical identical JJ cord-021413-1ht1xm88 17 9 agents agent NNS cord-021413-1ht1xm88 17 10 in in IN cord-021413-1ht1xm88 17 11 only only RB cord-021413-1ht1xm88 17 12 a a DT cord-021413-1ht1xm88 17 13 few few JJ cord-021413-1ht1xm88 17 14 such such JJ cord-021413-1ht1xm88 17 15 infants infant NNS cord-021413-1ht1xm88 17 16 could could MD cord-021413-1ht1xm88 17 17 confound confound VB cord-021413-1ht1xm88 17 18 and and CC cord-021413-1ht1xm88 17 19 compromise compromise VB cord-021413-1ht1xm88 17 20 the the DT cord-021413-1ht1xm88 17 21 validity validity NN cord-021413-1ht1xm88 17 22 of of IN cord-021413-1ht1xm88 17 23 observations observation NNS cord-021413-1ht1xm88 17 24 follow follow VBP cord-021413-1ht1xm88 17 25 ing e VBG cord-021413-1ht1xm88 17 26 the the DT cord-021413-1ht1xm88 17 27 inoculation inoculation NN cord-021413-1ht1xm88 17 28 of of IN cord-021413-1ht1xm88 17 29 test test NN cord-021413-1ht1xm88 17 30 materials material NNS cord-021413-1ht1xm88 17 31 . . . cord-021413-1ht1xm88 18 1 It -PRON- PRP cord-021413-1ht1xm88 18 2 should should MD cord-021413-1ht1xm88 18 3 be be VB cord-021413-1ht1xm88 18 4 pointed point VBN cord-021413-1ht1xm88 18 5 out out RP cord-021413-1ht1xm88 18 6 , , , cord-021413-1ht1xm88 18 7 too too RB cord-021413-1ht1xm88 18 8 , , , cord-021413-1ht1xm88 18 9 that that IN cord-021413-1ht1xm88 18 10 Collins Collins NNP cord-021413-1ht1xm88 18 11 and and CC cord-021413-1ht1xm88 18 12 Parker Parker NNP cord-021413-1ht1xm88 18 13 ( ( -LRB- cord-021413-1ht1xm88 18 14 1972 1972 CD cord-021413-1ht1xm88 18 15 ) ) -RRB- cord-021413-1ht1xm88 18 16 demonstrated demonstrate VBD cord-021413-1ht1xm88 18 17 both both DT cord-021413-1ht1xm88 18 18 reovirus reovirus NNP cord-021413-1ht1xm88 18 19 3 3 CD cord-021413-1ht1xm88 18 20 and and CC cord-021413-1ht1xm88 18 21 murine murine JJ cord-021413-1ht1xm88 18 22 hepatitis hepatitis NN cord-021413-1ht1xm88 18 23 virus virus NN cord-021413-1ht1xm88 18 24 as as IN cord-021413-1ht1xm88 18 25 contaminants contaminant NNS cord-021413-1ht1xm88 18 26 in in IN cord-021413-1ht1xm88 18 27 some some DT cord-021413-1ht1xm88 18 28 murine murine JJ cord-021413-1ht1xm88 18 29 leukemia leukemia NN cord-021413-1ht1xm88 18 30 and and CC cord-021413-1ht1xm88 18 31 transplantable transplantable JJ cord-021413-1ht1xm88 18 32 tumor tumor NN cord-021413-1ht1xm88 18 33 specimens specimen NNS cord-021413-1ht1xm88 18 34 . . . cord-021413-1ht1xm88 19 1 Whereas whereas IN cord-021413-1ht1xm88 19 2 it -PRON- PRP cord-021413-1ht1xm88 19 3 is be VBZ cord-021413-1ht1xm88 19 4 mainly mainly RB cord-021413-1ht1xm88 19 5 from from IN cord-021413-1ht1xm88 19 6 these these DT cord-021413-1ht1xm88 19 7 standpoints standpoint NNS cord-021413-1ht1xm88 19 8 that that WDT cord-021413-1ht1xm88 19 9 the the DT cord-021413-1ht1xm88 19 10 diseases disease NNS cord-021413-1ht1xm88 19 11 in in IN cord-021413-1ht1xm88 19 12 question question NN cord-021413-1ht1xm88 19 13 derive derive VBP cord-021413-1ht1xm88 19 14 importance importance NN cord-021413-1ht1xm88 19 15 , , , cord-021413-1ht1xm88 19 16 they -PRON- PRP cord-021413-1ht1xm88 19 17 should should MD cord-021413-1ht1xm88 19 18 not not RB cord-021413-1ht1xm88 19 19 be be VB cord-021413-1ht1xm88 19 20 dismissed dismiss VBN cord-021413-1ht1xm88 19 21 without without IN cord-021413-1ht1xm88 19 22 considering consider VBG cord-021413-1ht1xm88 19 23 their -PRON- PRP$ cord-021413-1ht1xm88 19 24 intrinsic intrinsic JJ cord-021413-1ht1xm88 19 25 value value NN cord-021413-1ht1xm88 19 26 as as IN cord-021413-1ht1xm88 19 27 models model NNS cord-021413-1ht1xm88 19 28 for for IN cord-021413-1ht1xm88 19 29 elucidat elucidat NNP cord-021413-1ht1xm88 19 30 ing e VBG cord-021413-1ht1xm88 19 31 the the DT cord-021413-1ht1xm88 19 32 pathogenesis pathogenesis NN cord-021413-1ht1xm88 19 33 and and CC cord-021413-1ht1xm88 19 34 control control NN cord-021413-1ht1xm88 19 35 of of IN cord-021413-1ht1xm88 19 36 related related JJ cord-021413-1ht1xm88 19 37 infections infection NNS cord-021413-1ht1xm88 19 38 in in IN cord-021413-1ht1xm88 19 39 man man NN cord-021413-1ht1xm88 19 40 and and CC cord-021413-1ht1xm88 19 41 other other JJ cord-021413-1ht1xm88 19 42 animals animal NNS cord-021413-1ht1xm88 19 43 as as RB cord-021413-1ht1xm88 19 44 well well RB cord-021413-1ht1xm88 19 45 as as IN cord-021413-1ht1xm88 19 46 their -PRON- PRP$ cord-021413-1ht1xm88 19 47 utility utility NN cord-021413-1ht1xm88 19 48 for for IN cord-021413-1ht1xm88 19 49 the the DT cord-021413-1ht1xm88 19 50 molecular molecular JJ cord-021413-1ht1xm88 19 51 biologist biologist NN cord-021413-1ht1xm88 19 52 . . . cord-021413-1ht1xm88 20 1 Cheever Cheever NNP cord-021413-1ht1xm88 20 2 and and CC cord-021413-1ht1xm88 20 3 Mueller Mueller NNP cord-021413-1ht1xm88 20 4 ( ( -LRB- cord-021413-1ht1xm88 20 5 1947 1947 CD cord-021413-1ht1xm88 20 6 , , , cord-021413-1ht1xm88 20 7 1948 1948 CD cord-021413-1ht1xm88 20 8 ) ) -RRB- cord-021413-1ht1xm88 20 9 , , , cord-021413-1ht1xm88 20 10 Pappenheimer Pappenheimer NNP cord-021413-1ht1xm88 20 11 and and CC cord-021413-1ht1xm88 20 12 En En NNP cord-021413-1ht1xm88 20 13 ders ders NNP cord-021413-1ht1xm88 20 14 ( ( -LRB- cord-021413-1ht1xm88 20 15 1947 1947 CD cord-021413-1ht1xm88 20 16 ) ) -RRB- cord-021413-1ht1xm88 20 17 , , , cord-021413-1ht1xm88 20 18 and and CC cord-021413-1ht1xm88 20 19 Pappenheimer Pappenheimer NNP cord-021413-1ht1xm88 20 20 and and CC cord-021413-1ht1xm88 20 21 Cheever Cheever NNP cord-021413-1ht1xm88 20 22 ( ( -LRB- cord-021413-1ht1xm88 20 23 1948 1948 CD cord-021413-1ht1xm88 20 24 ) ) -RRB- cord-021413-1ht1xm88 20 25 were be VBD cord-021413-1ht1xm88 20 26 the the DT cord-021413-1ht1xm88 20 27 first first JJ cord-021413-1ht1xm88 20 28 to to TO cord-021413-1ht1xm88 20 29 describe describe VB cord-021413-1ht1xm88 20 30 the the DT cord-021413-1ht1xm88 20 31 pathological pathological JJ cord-021413-1ht1xm88 20 32 changes change NNS cord-021413-1ht1xm88 20 33 and and CC cord-021413-1ht1xm88 20 34 epidemiology epidemiology NN cord-021413-1ht1xm88 20 35 of of IN cord-021413-1ht1xm88 20 36 EDIM EDIM NNP cord-021413-1ht1xm88 20 37 . . . cord-021413-1ht1xm88 21 1 Runner Runner NNP cord-021413-1ht1xm88 21 2 and and CC cord-021413-1ht1xm88 21 3 Palm Palm NNP cord-021413-1ht1xm88 21 4 ( ( -LRB- cord-021413-1ht1xm88 21 5 1953 1953 CD cord-021413-1ht1xm88 21 6 ) ) -RRB- cord-021413-1ht1xm88 21 7 and and CC cord-021413-1ht1xm88 21 8 Cheever Cheever NNP cord-021413-1ht1xm88 21 9 ( ( -LRB- cord-021413-1ht1xm88 21 10 1956 1956 CD cord-021413-1ht1xm88 21 11 ) ) -RRB- cord-021413-1ht1xm88 21 12 also also RB cord-021413-1ht1xm88 21 13 con con NNP cord-021413-1ht1xm88 21 14 tributed tribute VBN cord-021413-1ht1xm88 21 15 to to IN cord-021413-1ht1xm88 21 16 knowledge knowledge NN cord-021413-1ht1xm88 21 17 concerning concern VBG cord-021413-1ht1xm88 21 18 the the DT cord-021413-1ht1xm88 21 19 epidemiology epidemiology NN cord-021413-1ht1xm88 21 20 and and CC cord-021413-1ht1xm88 21 21 etiol etiol FW cord-021413-1ht1xm88 21 22 ogy ogy NNP cord-021413-1ht1xm88 21 23 of of IN cord-021413-1ht1xm88 21 24 the the DT cord-021413-1ht1xm88 21 25 disease disease NN cord-021413-1ht1xm88 21 26 . . . cord-021413-1ht1xm88 22 1 Thereafter Thereafter NNP cord-021413-1ht1xm88 22 2 Kraft Kraft NNP cord-021413-1ht1xm88 22 3 ( ( -LRB- cord-021413-1ht1xm88 22 4 1957 1957 CD cord-021413-1ht1xm88 22 5 Kraft Kraft NNP cord-021413-1ht1xm88 22 6 ( ( -LRB- cord-021413-1ht1xm88 22 7 , , , cord-021413-1ht1xm88 22 8 1958 1958 CD cord-021413-1ht1xm88 22 9 Kraft Kraft NNP cord-021413-1ht1xm88 22 10 ( ( -LRB- cord-021413-1ht1xm88 22 11 , , , cord-021413-1ht1xm88 22 12 1961 1961 CD cord-021413-1ht1xm88 22 13 Kraft Kraft NNP cord-021413-1ht1xm88 22 14 ( ( -LRB- cord-021413-1ht1xm88 22 15 , , , cord-021413-1ht1xm88 22 16 1962b 1962b CD cord-021413-1ht1xm88 22 17 Kraft Kraft NNP cord-021413-1ht1xm88 22 18 ( ( -LRB- cord-021413-1ht1xm88 22 19 , , , cord-021413-1ht1xm88 22 20 1966 1966 CD cord-021413-1ht1xm88 22 21 reported report VBD cord-021413-1ht1xm88 22 22 on on IN cord-021413-1ht1xm88 22 23 studies study NNS cord-021413-1ht1xm88 22 24 regarding regard VBG cord-021413-1ht1xm88 22 25 the the DT cord-021413-1ht1xm88 22 26 etiology etiology NN cord-021413-1ht1xm88 22 27 , , , cord-021413-1ht1xm88 22 28 mode mode NN cord-021413-1ht1xm88 22 29 of of IN cord-021413-1ht1xm88 22 30 transmission transmission NN cord-021413-1ht1xm88 22 31 , , , cord-021413-1ht1xm88 22 32 carrier carrier NN cord-021413-1ht1xm88 22 33 state state NN cord-021413-1ht1xm88 22 34 , , , cord-021413-1ht1xm88 22 35 immune immune JJ cord-021413-1ht1xm88 22 36 response response NN cord-021413-1ht1xm88 22 37 , , , cord-021413-1ht1xm88 22 38 pathogenesis pathogenesis NN cord-021413-1ht1xm88 22 39 , , , cord-021413-1ht1xm88 22 40 and and CC cord-021413-1ht1xm88 22 41 control control NN cord-021413-1ht1xm88 22 42 of of IN cord-021413-1ht1xm88 22 43 the the DT cord-021413-1ht1xm88 22 44 disease disease NN cord-021413-1ht1xm88 22 45 . . . cord-021413-1ht1xm88 23 1 Serologic Serologic NNP cord-021413-1ht1xm88 23 2 studies study NNS cord-021413-1ht1xm88 23 3 were be VBD cord-021413-1ht1xm88 23 4 also also RB cord-021413-1ht1xm88 23 5 under under IN cord-021413-1ht1xm88 23 6 taken take VBN cord-021413-1ht1xm88 23 7 by by IN cord-021413-1ht1xm88 23 8 Blackwell Blackwell NNP cord-021413-1ht1xm88 23 9 et et NNP cord-021413-1ht1xm88 23 10 aL aL NNP cord-021413-1ht1xm88 23 11 ( ( -LRB- cord-021413-1ht1xm88 23 12 1966 1966 CD cord-021413-1ht1xm88 23 13 ) ) -RRB- cord-021413-1ht1xm88 23 14 . . . cord-021413-1ht1xm88 24 1 Kraft Kraft NNP cord-021413-1ht1xm88 24 2 ( ( -LRB- cord-021413-1ht1xm88 24 3 1963 1963 CD cord-021413-1ht1xm88 24 4 , , , cord-021413-1ht1xm88 24 5 1967 1967 CD cord-021413-1ht1xm88 24 6 ) ) -RRB- cord-021413-1ht1xm88 24 7 first first RB cord-021413-1ht1xm88 24 8 demonstrated demonstrate VBD cord-021413-1ht1xm88 24 9 the the DT cord-021413-1ht1xm88 24 10 agent agent NN cord-021413-1ht1xm88 24 11 in in IN cord-021413-1ht1xm88 24 12 electron electron NN cord-021413-1ht1xm88 24 13 micrographs micrograph NNS cord-021413-1ht1xm88 24 14 of of IN cord-021413-1ht1xm88 24 15 infected infected JJ cord-021413-1ht1xm88 24 16 infant infant NN cord-021413-1ht1xm88 24 17 mouse mouse NN cord-021413-1ht1xm88 24 18 intestinal intestinal JJ cord-021413-1ht1xm88 24 19 epithelium epithelium NN cord-021413-1ht1xm88 24 20 . . . cord-021413-1ht1xm88 25 1 Banfield Banfield NNP cord-021413-1ht1xm88 25 2 et et NNP cord-021413-1ht1xm88 25 3 aL aL NNP cord-021413-1ht1xm88 25 4 ( ( -LRB- cord-021413-1ht1xm88 25 5 1968 1968 CD cord-021413-1ht1xm88 25 6 ) ) -RRB- cord-021413-1ht1xm88 25 7 enlarged enlarge VBN cord-021413-1ht1xm88 25 8 on on IN cord-021413-1ht1xm88 25 9 those those DT cord-021413-1ht1xm88 25 10 findings finding NNS cord-021413-1ht1xm88 25 11 , , , cord-021413-1ht1xm88 25 12 comparing compare VBG cord-021413-1ht1xm88 25 13 the the DT cord-021413-1ht1xm88 25 14 virions virion NNS cord-021413-1ht1xm88 25 15 to to IN cord-021413-1ht1xm88 25 16 those those DT cord-021413-1ht1xm88 25 17 of of IN cord-021413-1ht1xm88 25 18 the the DT cord-021413-1ht1xm88 25 19 reoviruses reovirus NNS cord-021413-1ht1xm88 25 20 . . . cord-021413-1ht1xm88 26 1 Particles particle NNS cord-021413-1ht1xm88 26 2 of of IN cord-021413-1ht1xm88 26 3 similar similar JJ cord-021413-1ht1xm88 26 4 morphology morphology NN cord-021413-1ht1xm88 26 5 were be VBD cord-021413-1ht1xm88 26 6 subsequently subsequently RB cord-021413-1ht1xm88 26 7 observed observe VBN cord-021413-1ht1xm88 26 8 in in IN cord-021413-1ht1xm88 26 9 the the DT cord-021413-1ht1xm88 26 10 diarrheal diarrheal JJ cord-021413-1ht1xm88 26 11 feces fece NNS cord-021413-1ht1xm88 26 12 of of IN cord-021413-1ht1xm88 26 13 many many JJ cord-021413-1ht1xm88 26 14 species specie NNS cord-021413-1ht1xm88 26 15 , , , cord-021413-1ht1xm88 26 16 primarily primarily RB cord-021413-1ht1xm88 26 17 in in IN cord-021413-1ht1xm88 26 18 the the DT cord-021413-1ht1xm88 26 19 young young JJ cord-021413-1ht1xm88 26 20 : : : cord-021413-1ht1xm88 27 1 cattle cattle NNS cord-021413-1ht1xm88 27 2 ( ( -LRB- cord-021413-1ht1xm88 27 3 Mebus Mebus NNP cord-021413-1ht1xm88 27 4 et et NNP cord-021413-1ht1xm88 27 5 aL aL NNP cord-021413-1ht1xm88 27 6 , , , cord-021413-1ht1xm88 27 7 1969 1969 CD cord-021413-1ht1xm88 27 8 ) ) -RRB- cord-021413-1ht1xm88 27 9 , , , cord-021413-1ht1xm88 27 10 man man NN cord-021413-1ht1xm88 27 11 ( ( -LRB- cord-021413-1ht1xm88 27 12 Flewett Flewett NNP cord-021413-1ht1xm88 27 13 et et FW cord-021413-1ht1xm88 27 14 aL aL NNP cord-021413-1ht1xm88 27 15 , , , cord-021413-1ht1xm88 27 16 191 191 CD cord-021413-1ht1xm88 27 17 A A NNP cord-021413-1ht1xm88 27 18 ) ) -RRB- cord-021413-1ht1xm88 27 19 , , , cord-021413-1ht1xm88 27 20 horse horse NN cord-021413-1ht1xm88 27 21 ( ( -LRB- cord-021413-1ht1xm88 27 22 Flewett Flewett NNP cord-021413-1ht1xm88 27 23 et et FW cord-021413-1ht1xm88 27 24 aL aL NNP cord-021413-1ht1xm88 27 25 , , , cord-021413-1ht1xm88 27 26 1975 1975 CD cord-021413-1ht1xm88 27 27 ) ) -RRB- cord-021413-1ht1xm88 27 28 , , , cord-021413-1ht1xm88 27 29 pig pig NN cord-021413-1ht1xm88 27 30 ( ( -LRB- cord-021413-1ht1xm88 27 31 Rodger Rodger NNP cord-021413-1ht1xm88 27 32 et et NNP cord-021413-1ht1xm88 27 33 aL aL NNP cord-021413-1ht1xm88 27 34 , , , cord-021413-1ht1xm88 27 35 1975 1975 CD cord-021413-1ht1xm88 27 36 ) ) -RRB- cord-021413-1ht1xm88 27 37 , , , cord-021413-1ht1xm88 27 38 sheep sheep NN cord-021413-1ht1xm88 27 39 , , , cord-021413-1ht1xm88 27 40 rabbit rabbit NN cord-021413-1ht1xm88 27 41 , , , cord-021413-1ht1xm88 27 42 deer deer NN cord-021413-1ht1xm88 27 43 ( ( -LRB- cord-021413-1ht1xm88 27 44 Tzipori Tzipori NNP cord-021413-1ht1xm88 27 45 et et NNP cord-021413-1ht1xm88 27 46 aL aL NNP cord-021413-1ht1xm88 27 47 , , , cord-021413-1ht1xm88 27 48 1976 1976 CD cord-021413-1ht1xm88 27 49 ) ) -RRB- cord-021413-1ht1xm88 27 50 , , , cord-021413-1ht1xm88 27 51 goat goat NNP cord-021413-1ht1xm88 27 52 ( ( -LRB- cord-021413-1ht1xm88 27 53 Scott Scott NNP cord-021413-1ht1xm88 27 54 et et NNP cord-021413-1ht1xm88 27 55 aL aL NNP cord-021413-1ht1xm88 27 56 , , , cord-021413-1ht1xm88 27 57 1978 1978 CD cord-021413-1ht1xm88 27 58 ) ) -RRB- cord-021413-1ht1xm88 27 59 , , , cord-021413-1ht1xm88 27 60 and and CC cord-021413-1ht1xm88 27 61 dog dog NN cord-021413-1ht1xm88 27 62 ( ( -LRB- cord-021413-1ht1xm88 27 63 England England NNP cord-021413-1ht1xm88 27 64 and and CC cord-021413-1ht1xm88 27 65 Poston Poston NNP cord-021413-1ht1xm88 27 66 , , , cord-021413-1ht1xm88 27 67 1980 1980 CD cord-021413-1ht1xm88 27 68 ) ) -RRB- cord-021413-1ht1xm88 27 69 . . . cord-021413-1ht1xm88 28 1 In in IN cord-021413-1ht1xm88 28 2 addition addition NN cord-021413-1ht1xm88 28 3 , , , cord-021413-1ht1xm88 28 4 one one CD cord-021413-1ht1xm88 28 5 virus virus NN cord-021413-1ht1xm88 28 6 , , , cord-021413-1ht1xm88 28 7 SA-11 SA-11 NNP cord-021413-1ht1xm88 28 8 , , , cord-021413-1ht1xm88 28 9 was be VBD cord-021413-1ht1xm88 28 10 isolated isolate VBN cord-021413-1ht1xm88 28 11 from from IN cord-021413-1ht1xm88 28 12 a a DT cord-021413-1ht1xm88 28 13 nondiarrheal nondiarrheal NN cord-021413-1ht1xm88 28 14 monkey monkey NN cord-021413-1ht1xm88 28 15 , , , cord-021413-1ht1xm88 28 16 and and CC cord-021413-1ht1xm88 28 17 another another DT cord-021413-1ht1xm88 28 18 , , , cord-021413-1ht1xm88 28 19 OA OA NNP cord-021413-1ht1xm88 28 20 ( ( -LRB- cord-021413-1ht1xm88 28 21 offal offal NN cord-021413-1ht1xm88 28 22 agent agent NN cord-021413-1ht1xm88 28 23 ) ) -RRB- cord-021413-1ht1xm88 28 24 , , , cord-021413-1ht1xm88 28 25 was be VBD cord-021413-1ht1xm88 28 26 recovered recover VBN cord-021413-1ht1xm88 28 27 from from IN cord-021413-1ht1xm88 28 28 intestinal intestinal JJ cord-021413-1ht1xm88 28 29 washings washing NNS cord-021413-1ht1xm88 28 30 of of IN cord-021413-1ht1xm88 28 31 sheep sheep NNS cord-021413-1ht1xm88 28 32 in in IN cord-021413-1ht1xm88 28 33 an an DT cord-021413-1ht1xm88 28 34 abattoir abattoir NN cord-021413-1ht1xm88 28 35 ( ( -LRB- cord-021413-1ht1xm88 28 36 Els Els NNP cord-021413-1ht1xm88 28 37 and and CC cord-021413-1ht1xm88 28 38 Lecatsas Lecatsas NNP cord-021413-1ht1xm88 28 39 , , , cord-021413-1ht1xm88 28 40 1972 1972 CD cord-021413-1ht1xm88 28 41 ) ) -RRB- cord-021413-1ht1xm88 28 42 . . . cord-021413-1ht1xm88 29 1 Much much JJ cord-021413-1ht1xm88 29 2 and and CC cord-021413-1ht1xm88 29 3 Zajac Zajac NNP cord-021413-1ht1xm88 29 4 ( ( -LRB- cord-021413-1ht1xm88 29 5 1972 1972 CD cord-021413-1ht1xm88 29 6 ) ) -RRB- cord-021413-1ht1xm88 29 7 purified purify VBN cord-021413-1ht1xm88 29 8 EDIM EDIM NNP cord-021413-1ht1xm88 29 9 virus virus NN cord-021413-1ht1xm88 29 10 from from IN cord-021413-1ht1xm88 29 11 diarrheal diarrheal JJ cord-021413-1ht1xm88 29 12 infant infant NN cord-021413-1ht1xm88 29 13 mice mouse NNS cord-021413-1ht1xm88 29 14 and and CC cord-021413-1ht1xm88 29 15 further further RB cord-021413-1ht1xm88 29 16 characterized characterize VBD cord-021413-1ht1xm88 29 17 it -PRON- PRP cord-021413-1ht1xm88 29 18 . . . cord-021413-1ht1xm88 30 1 Based base VBN cord-021413-1ht1xm88 30 2 on on IN cord-021413-1ht1xm88 30 3 its -PRON- PRP$ cord-021413-1ht1xm88 30 4 moφhology moφhology NN cord-021413-1ht1xm88 30 5 and and CC cord-021413-1ht1xm88 30 6 other other JJ cord-021413-1ht1xm88 30 7 known know VBN cord-021413-1ht1xm88 30 8 characters character NNS cord-021413-1ht1xm88 30 9 , , , cord-021413-1ht1xm88 30 10 EDIM EDIM NNP cord-021413-1ht1xm88 30 11 virus virus NN cord-021413-1ht1xm88 30 12 has have VBZ cord-021413-1ht1xm88 30 13 been be VBN cord-021413-1ht1xm88 30 14 placed place VBN cord-021413-1ht1xm88 30 15 into into IN cord-021413-1ht1xm88 30 16 the the DT cord-021413-1ht1xm88 30 17 genus genus NN cord-021413-1ht1xm88 30 18 Rotavirus rotavirus NN cord-021413-1ht1xm88 30 19 in in IN cord-021413-1ht1xm88 30 20 the the DT cord-021413-1ht1xm88 30 21 family family NN cord-021413-1ht1xm88 30 22 Reoviridae Reoviridae NNP cord-021413-1ht1xm88 30 23 ( ( -LRB- cord-021413-1ht1xm88 30 24 Matthews Matthews NNP cord-021413-1ht1xm88 30 25 , , , cord-021413-1ht1xm88 30 26 1979 1979 CD cord-021413-1ht1xm88 30 27 ) ) -RRB- cord-021413-1ht1xm88 30 28 . . . cord-021413-1ht1xm88 31 1 During during IN cord-021413-1ht1xm88 31 2 the the DT cord-021413-1ht1xm88 31 3 past past JJ cord-021413-1ht1xm88 31 4 decade decade NN cord-021413-1ht1xm88 31 5 , , , cord-021413-1ht1xm88 31 6 knowl knowl JJ cord-021413-1ht1xm88 31 7 edge edge NN cord-021413-1ht1xm88 31 8 of of IN cord-021413-1ht1xm88 31 9 the the DT cord-021413-1ht1xm88 31 10 rotaviruses rotavirus NNS cord-021413-1ht1xm88 31 11 as as IN cord-021413-1ht1xm88 31 12 agents agent NNS cord-021413-1ht1xm88 31 13 of of IN cord-021413-1ht1xm88 31 14 diarrheal diarrheal JJ cord-021413-1ht1xm88 31 15 disease disease NN cord-021413-1ht1xm88 31 16 of of IN cord-021413-1ht1xm88 31 17 young young JJ cord-021413-1ht1xm88 31 18 mammals mammal NNS cord-021413-1ht1xm88 31 19 has have VBZ cord-021413-1ht1xm88 31 20 burgeoned burgeon VBN cord-021413-1ht1xm88 31 21 , , , cord-021413-1ht1xm88 31 22 especially especially RB cord-021413-1ht1xm88 31 23 with with IN cord-021413-1ht1xm88 31 24 regard regard NN cord-021413-1ht1xm88 31 25 to to IN cord-021413-1ht1xm88 31 26 those those DT cord-021413-1ht1xm88 31 27 af af NN cord-021413-1ht1xm88 31 28 fecting fecte VBG cord-021413-1ht1xm88 31 29 children child NNS cord-021413-1ht1xm88 31 30 , , , cord-021413-1ht1xm88 31 31 calves calf NNS cord-021413-1ht1xm88 31 32 , , , cord-021413-1ht1xm88 31 33 and and CC cord-021413-1ht1xm88 31 34 piglets piglet NNS cord-021413-1ht1xm88 31 35 . . . cord-021413-1ht1xm88 32 1 Reviews review NNS cord-021413-1ht1xm88 32 2 concerning concern VBG cord-021413-1ht1xm88 32 3 the the DT cord-021413-1ht1xm88 32 4 genus genus NN cord-021413-1ht1xm88 32 5 have have VBP cord-021413-1ht1xm88 32 6 been be VBN cord-021413-1ht1xm88 32 7 published publish VBN cord-021413-1ht1xm88 32 8 by by IN cord-021413-1ht1xm88 32 9 Wyatt Wyatt NNP cord-021413-1ht1xm88 32 10 et et NNP cord-021413-1ht1xm88 32 11 aL aL NNP cord-021413-1ht1xm88 32 12 ( ( -LRB- cord-021413-1ht1xm88 32 13 1978 1978 CD cord-021413-1ht1xm88 32 14 ) ) -RRB- cord-021413-1ht1xm88 32 15 , , , cord-021413-1ht1xm88 32 16 McNulty McNulty NNP cord-021413-1ht1xm88 32 17 ( ( -LRB- cord-021413-1ht1xm88 32 18 1978 1978 CD cord-021413-1ht1xm88 32 19 , , , cord-021413-1ht1xm88 32 20 Flewett Flewett NNP cord-021413-1ht1xm88 32 21 and and CC cord-021413-1ht1xm88 32 22 Woode Woode NNP cord-021413-1ht1xm88 32 23 ( ( -LRB- cord-021413-1ht1xm88 32 24 1978 1978 CD cord-021413-1ht1xm88 32 25 ) ) -RRB- cord-021413-1ht1xm88 32 26 , , , cord-021413-1ht1xm88 32 27 Andrewes Andrewes NNP cord-021413-1ht1xm88 32 28 et et FW cord-021413-1ht1xm88 32 29 aL aL NNP cord-021413-1ht1xm88 32 30 ( ( -LRB- cord-021413-1ht1xm88 32 31 1978 1978 CD cord-021413-1ht1xm88 32 32 ) ) -RRB- cord-021413-1ht1xm88 32 33 , , , cord-021413-1ht1xm88 32 34 and and CC cord-021413-1ht1xm88 32 35 Holmes Holmes NNP cord-021413-1ht1xm88 32 36 ( ( -LRB- cord-021413-1ht1xm88 32 37 1979 1979 CD cord-021413-1ht1xm88 32 38 ) ) -RRB- cord-021413-1ht1xm88 32 39 . . . cord-021413-1ht1xm88 33 1 Additional additional JJ cord-021413-1ht1xm88 33 2 comments comment NNS cord-021413-1ht1xm88 33 3 may may MD cord-021413-1ht1xm88 33 4 be be VB cord-021413-1ht1xm88 33 5 found find VBN cord-021413-1ht1xm88 33 6 in in IN cord-021413-1ht1xm88 33 7 the the DT cord-021413-1ht1xm88 33 8 American American NNP cord-021413-1ht1xm88 33 9 Veterinary Veterinary NNP cord-021413-1ht1xm88 33 10 Medical Medical NNP cord-021413-1ht1xm88 33 11 Association Association NNP cord-021413-1ht1xm88 33 12 Panel Panel NNP cord-021413-1ht1xm88 33 13 the the DT cord-021413-1ht1xm88 33 14 Young Young NNP cord-021413-1ht1xm88 33 15 ( ( -LRB- cord-021413-1ht1xm88 33 16 Anonymous Anonymous NNP cord-021413-1ht1xm88 33 17 , , , cord-021413-1ht1xm88 33 18 1978 1978 CD cord-021413-1ht1xm88 33 19 ) ) -RRB- cord-021413-1ht1xm88 33 20 . . . cord-021413-1ht1xm88 34 1 The the DT cord-021413-1ht1xm88 34 2 classification classification NN cord-021413-1ht1xm88 34 3 of of IN cord-021413-1ht1xm88 34 4 EDIM EDIM NNP cord-021413-1ht1xm88 34 5 virus virus NN cord-021413-1ht1xm88 34 6 in in IN cord-021413-1ht1xm88 34 7 the the DT cord-021413-1ht1xm88 34 8 genus genus NN cord-021413-1ht1xm88 34 9 Rotavirus rotavirus NN cord-021413-1ht1xm88 34 10 , , , cord-021413-1ht1xm88 34 11 family family NN cord-021413-1ht1xm88 34 12 Roeviridae Roeviridae NNP cord-021413-1ht1xm88 34 13 , , , cord-021413-1ht1xm88 34 14 derives derive VBZ cord-021413-1ht1xm88 34 15 from from IN cord-021413-1ht1xm88 34 16 its -PRON- PRP$ cord-021413-1ht1xm88 34 17 moφhology moφhology NN cord-021413-1ht1xm88 34 18 and and CC cord-021413-1ht1xm88 34 19 mode mode NN cord-021413-1ht1xm88 34 20 of of IN cord-021413-1ht1xm88 34 21 replication replication NN cord-021413-1ht1xm88 34 22 as as IN cord-021413-1ht1xm88 34 23 seen see VBN cord-021413-1ht1xm88 34 24 in in IN cord-021413-1ht1xm88 34 25 electron electron NN cord-021413-1ht1xm88 34 26 micrographs micrograph NNS cord-021413-1ht1xm88 34 27 ( ( -LRB- cord-021413-1ht1xm88 34 28 Adams Adams NNP cord-021413-1ht1xm88 34 29 and and CC cord-021413-1ht1xm88 34 30 Kraft Kraft NNP cord-021413-1ht1xm88 34 31 , , , cord-021413-1ht1xm88 34 32 1967 1967 CD cord-021413-1ht1xm88 34 33 ; ; : cord-021413-1ht1xm88 34 34 Banfield Banfield NNP cord-021413-1ht1xm88 34 35 et et NNP cord-021413-1ht1xm88 34 36 aL aL NNP cord-021413-1ht1xm88 34 37 , , , cord-021413-1ht1xm88 34 38 1968 1968 CD cord-021413-1ht1xm88 34 39 ) ) -RRB- cord-021413-1ht1xm88 34 40 , , , cord-021413-1ht1xm88 34 41 which which WDT cord-021413-1ht1xm88 34 42 were be VBD cord-021413-1ht1xm88 34 43 later later RB cord-021413-1ht1xm88 34 44 shown show VBN cord-021413-1ht1xm88 34 45 to to TO cord-021413-1ht1xm88 34 46 re re VB cord-021413-1ht1xm88 34 47 semble semble FW cord-021413-1ht1xm88 34 48 those those DT cord-021413-1ht1xm88 34 49 observed observe VBN cord-021413-1ht1xm88 34 50 in in IN cord-021413-1ht1xm88 34 51 ultrathin ultrathin JJ cord-021413-1ht1xm88 34 52 sections section NNS cord-021413-1ht1xm88 34 53 in in IN cord-021413-1ht1xm88 34 54 human human JJ cord-021413-1ht1xm88 34 55 intestinal intestinal JJ cord-021413-1ht1xm88 34 56 material material NN cord-021413-1ht1xm88 34 57 containing contain VBG cord-021413-1ht1xm88 34 58 ' ' '' cord-021413-1ht1xm88 34 59 ' ' `` cord-021413-1ht1xm88 34 60 reovirus reovirus NN cord-021413-1ht1xm88 34 61 - - HYPH cord-021413-1ht1xm88 34 62 like like JJ cord-021413-1ht1xm88 34 63 " " `` cord-021413-1ht1xm88 34 64 particles particle NNS cord-021413-1ht1xm88 34 65 ( ( -LRB- cord-021413-1ht1xm88 34 66 Bishop Bishop NNP cord-021413-1ht1xm88 34 67 et et NNP cord-021413-1ht1xm88 34 68 aL aL NNP cord-021413-1ht1xm88 34 69 , , , cord-021413-1ht1xm88 34 70 1973 1973 CD cord-021413-1ht1xm88 34 71 ) ) -RRB- cord-021413-1ht1xm88 34 72 . . . cord-021413-1ht1xm88 35 1 The the DT cord-021413-1ht1xm88 35 2 term term NN cord-021413-1ht1xm88 35 3 rotavirus rotavirus NN cord-021413-1ht1xm88 35 4 ( ( -LRB- cord-021413-1ht1xm88 35 5 L. L. NNP cord-021413-1ht1xm88 35 6 rota rota NN cord-021413-1ht1xm88 35 7 , , , cord-021413-1ht1xm88 35 8 wheel wheel NN cord-021413-1ht1xm88 35 9 ) ) -RRB- cord-021413-1ht1xm88 35 10 was be VBD cord-021413-1ht1xm88 35 11 proposed propose VBN cord-021413-1ht1xm88 35 12 by by IN cord-021413-1ht1xm88 35 13 Flewett Flewett NNP cord-021413-1ht1xm88 35 14 et et FW cord-021413-1ht1xm88 35 15 aL aL NNP cord-021413-1ht1xm88 35 16 ( ( -LRB- cord-021413-1ht1xm88 35 17 1974 1974 CD cord-021413-1ht1xm88 35 18 ) ) -RRB- cord-021413-1ht1xm88 35 19 because because IN cord-021413-1ht1xm88 35 20 of of IN cord-021413-1ht1xm88 35 21 its -PRON- PRP$ cord-021413-1ht1xm88 35 22 moφhology moφhology NN cord-021413-1ht1xm88 35 23 as as IN cord-021413-1ht1xm88 35 24 viewed view VBN cord-021413-1ht1xm88 35 25 in in IN cord-021413-1ht1xm88 35 26 negative negative JJ cord-021413-1ht1xm88 35 27 - - HYPH cord-021413-1ht1xm88 35 28 contrast contrast NN cord-021413-1ht1xm88 35 29 electron electron NN cord-021413-1ht1xm88 35 30 micrographs micrograph NNS cord-021413-1ht1xm88 35 31 . . . cord-021413-1ht1xm88 36 1 It -PRON- PRP cord-021413-1ht1xm88 36 2 has have VBZ cord-021413-1ht1xm88 36 3 become become VBN cord-021413-1ht1xm88 36 4 widely widely RB cord-021413-1ht1xm88 36 5 used use VBN cord-021413-1ht1xm88 36 6 in in IN cord-021413-1ht1xm88 36 7 preference preference NN cord-021413-1ht1xm88 36 8 to to IN cord-021413-1ht1xm88 36 9 duovirus duovirus NNP cord-021413-1ht1xm88 36 10 , , , cord-021413-1ht1xm88 36 11 which which WDT cord-021413-1ht1xm88 36 12 is be VBZ cord-021413-1ht1xm88 36 13 synonymous synonymous JJ cord-021413-1ht1xm88 36 14 ( ( -LRB- cord-021413-1ht1xm88 36 15 David David NNP cord-021413-1ht1xm88 36 16 son son NN cord-021413-1ht1xm88 36 17 et et NNP cord-021413-1ht1xm88 36 18 aL aL NNP cord-021413-1ht1xm88 36 19 , , , cord-021413-1ht1xm88 36 20 1975 1975 CD cord-021413-1ht1xm88 36 21 ) ) -RRB- cord-021413-1ht1xm88 36 22 . . . cord-021413-1ht1xm88 37 1 There there EX cord-021413-1ht1xm88 37 2 is be VBZ cord-021413-1ht1xm88 37 3 no no DT cord-021413-1ht1xm88 37 4 evidence evidence NN cord-021413-1ht1xm88 37 5 that that IN cord-021413-1ht1xm88 37 6 antigenic antigenic JJ cord-021413-1ht1xm88 37 7 or or CC cord-021413-1ht1xm88 37 8 pathogenetic pathogenetic JJ cord-021413-1ht1xm88 37 9 variants variant NNS cord-021413-1ht1xm88 37 10 of of IN cord-021413-1ht1xm88 37 11 EDIM EDIM NNP cord-021413-1ht1xm88 37 12 virus virus NN cord-021413-1ht1xm88 37 13 exist exist VBP cord-021413-1ht1xm88 37 14 . . . cord-021413-1ht1xm88 38 1 Analysis Analysis NNP cord-021413-1ht1xm88 38 2 of of IN cord-021413-1ht1xm88 38 3 RNA RNA NNP cord-021413-1ht1xm88 38 4 segment segment NN cord-021413-1ht1xm88 38 5 and and CC cord-021413-1ht1xm88 38 6 struc struc NNP cord-021413-1ht1xm88 38 7 tural tural NNP cord-021413-1ht1xm88 38 8 polypeptide polypeptide NN cord-021413-1ht1xm88 38 9 variation variation NN cord-021413-1ht1xm88 38 10 , , , cord-021413-1ht1xm88 38 11 however however RB cord-021413-1ht1xm88 38 12 , , , cord-021413-1ht1xm88 38 13 as as IN cord-021413-1ht1xm88 38 14 has have VBZ cord-021413-1ht1xm88 38 15 been be VBN cord-021413-1ht1xm88 38 16 accom accom NNP cord-021413-1ht1xm88 38 17 plished plishe VBN cord-021413-1ht1xm88 38 18 for for IN cord-021413-1ht1xm88 38 19 other other JJ cord-021413-1ht1xm88 38 20 rotaviruses rotavirus NNS cord-021413-1ht1xm88 38 21 Derbyshire Derbyshire NNP cord-021413-1ht1xm88 38 22 and and CC cord-021413-1ht1xm88 38 23 Woode Woode NNP cord-021413-1ht1xm88 38 24 , , , cord-021413-1ht1xm88 38 25 1978 1978 CD cord-021413-1ht1xm88 38 26 ; ; : cord-021413-1ht1xm88 38 27 Rodger Rodger NNP cord-021413-1ht1xm88 38 28 and and CC cord-021413-1ht1xm88 38 29 Holmes Holmes NNP cord-021413-1ht1xm88 38 30 , , , cord-021413-1ht1xm88 38 31 1979 1979 CD cord-021413-1ht1xm88 38 32 ) ) -RRB- cord-021413-1ht1xm88 38 33 , , , cord-021413-1ht1xm88 38 34 may may MD cord-021413-1ht1xm88 38 35 reveal reveal VB cord-021413-1ht1xm88 38 36 differences difference NNS cord-021413-1ht1xm88 38 37 among among IN cord-021413-1ht1xm88 38 38 strains strain NNS cord-021413-1ht1xm88 38 39 . . . cord-021413-1ht1xm88 39 1 Further further RB cord-021413-1ht1xm88 39 2 , , , cord-021413-1ht1xm88 39 3 several several JJ cord-021413-1ht1xm88 39 4 serotypes serotype NNS cord-021413-1ht1xm88 39 5 have have VBP cord-021413-1ht1xm88 39 6 been be VBN cord-021413-1ht1xm88 39 7 described describe VBN cord-021413-1ht1xm88 39 8 a a DT cord-021413-1ht1xm88 39 9 m m NN cord-021413-1ht1xm88 39 10 o o NN cord-021413-1ht1xm88 39 11 n n NN cord-021413-1ht1xm88 39 12 g g NN cord-021413-1ht1xm88 39 13 the the DT cord-021413-1ht1xm88 39 14 h h NN cord-021413-1ht1xm88 39 15 u u NNP cord-021413-1ht1xm88 39 16 m m NNP cord-021413-1ht1xm88 39 17 a a NNP cord-021413-1ht1xm88 39 18 n n NNP cord-021413-1ht1xm88 39 19 rotaviruses rotaviruses NNP cord-021413-1ht1xm88 39 20 by by IN cord-021413-1ht1xm88 39 21 m m NNP cord-021413-1ht1xm88 39 22 e e NNP cord-021413-1ht1xm88 39 23 a a NNP cord-021413-1ht1xm88 39 24 n n NNP cord-021413-1ht1xm88 39 25 s s NNP cord-021413-1ht1xm88 39 26 of of IN cord-021413-1ht1xm88 39 27 the the DT cord-021413-1ht1xm88 39 28 serum serum NN cord-021413-1ht1xm88 39 29 neutralization neutralization NN cord-021413-1ht1xm88 39 30 test test NN cord-021413-1ht1xm88 39 31 ( ( -LRB- cord-021413-1ht1xm88 39 32 Beards beard NNS cord-021413-1ht1xm88 39 33 et et NNP cord-021413-1ht1xm88 39 34 al al NNP cord-021413-1ht1xm88 39 35 . . NNP cord-021413-1ht1xm88 39 36 , , , cord-021413-1ht1xm88 39 37 1980 1980 CD cord-021413-1ht1xm88 39 38 ) ) -RRB- cord-021413-1ht1xm88 39 39 . . . cord-021413-1ht1xm88 40 1 This this DT cord-021413-1ht1xm88 40 2 technique technique NN cord-021413-1ht1xm88 40 3 may may MD cord-021413-1ht1xm88 40 4 also also RB cord-021413-1ht1xm88 40 5 prove prove VB cord-021413-1ht1xm88 40 6 useful useful JJ cord-021413-1ht1xm88 40 7 in in IN cord-021413-1ht1xm88 40 8 future future JJ cord-021413-1ht1xm88 40 9 studies study NNS cord-021413-1ht1xm88 40 10 of of IN cord-021413-1ht1xm88 40 11 E e NN cord-021413-1ht1xm88 40 12 D d NN cord-021413-1ht1xm88 40 13 I i NN cord-021413-1ht1xm88 40 14 M M NNP cord-021413-1ht1xm88 40 15 virus virus NN cord-021413-1ht1xm88 40 16 strains strain NNS cord-021413-1ht1xm88 40 17 . . . cord-021413-1ht1xm88 41 1 a. a. NN cord-021413-1ht1xm88 41 2 Morphology morphology NN cord-021413-1ht1xm88 41 3 , , , cord-021413-1ht1xm88 41 4 Size size NN cord-021413-1ht1xm88 41 5 , , , cord-021413-1ht1xm88 41 6 and and CC cord-021413-1ht1xm88 41 7 Composition composition NN cord-021413-1ht1xm88 41 8 . . . cord-021413-1ht1xm88 42 1 Kraft Kraft NNP cord-021413-1ht1xm88 42 2 ( ( -LRB- cord-021413-1ht1xm88 42 3 1962b 1962b CD cord-021413-1ht1xm88 42 4 ) ) -RRB- cord-021413-1ht1xm88 42 5 , , , cord-021413-1ht1xm88 42 6 using use VBG cord-021413-1ht1xm88 42 7 Millipore Millipore NNP cord-021413-1ht1xm88 42 8 filters filter NNS cord-021413-1ht1xm88 42 9 , , , cord-021413-1ht1xm88 42 10 determined determine VBD cord-021413-1ht1xm88 42 11 the the DT cord-021413-1ht1xm88 42 12 size size NN cord-021413-1ht1xm88 42 13 of of IN cord-021413-1ht1xm88 42 14 the the DT cord-021413-1ht1xm88 42 15 infective infective JJ cord-021413-1ht1xm88 42 16 E e NN cord-021413-1ht1xm88 42 17 D d NN cord-021413-1ht1xm88 42 18 I i NN cord-021413-1ht1xm88 42 19 M m CD cord-021413-1ht1xm88 42 20 virion virion NN cord-021413-1ht1xm88 42 21 to to TO cord-021413-1ht1xm88 42 22 be be VB cord-021413-1ht1xm88 42 23 between between IN cord-021413-1ht1xm88 42 24 33 33 CD cord-021413-1ht1xm88 42 25 and and CC cord-021413-1ht1xm88 42 26 100 100 CD cord-021413-1ht1xm88 42 27 n n NN cord-021413-1ht1xm88 42 28 m m NN cord-021413-1ht1xm88 42 29 . . . cord-021413-1ht1xm88 43 1 In in IN cord-021413-1ht1xm88 43 2 electron electron NN cord-021413-1ht1xm88 43 3 micro micro FW cord-021413-1ht1xm88 43 4 graphs graph NNS cord-021413-1ht1xm88 43 5 , , , cord-021413-1ht1xm88 43 6 A A NNP cord-021413-1ht1xm88 43 7 d d NN cord-021413-1ht1xm88 43 8 a a NN cord-021413-1ht1xm88 43 9 m m NNP cord-021413-1ht1xm88 43 10 s s NNP cord-021413-1ht1xm88 43 11 and and CC cord-021413-1ht1xm88 43 12 Kraft Kraft NNP cord-021413-1ht1xm88 43 13 ( ( -LRB- cord-021413-1ht1xm88 43 14 1967 1967 CD cord-021413-1ht1xm88 43 15 ) ) -RRB- cord-021413-1ht1xm88 43 16 mined mine VBD cord-021413-1ht1xm88 43 17 the the DT cord-021413-1ht1xm88 43 18 m m NNP cord-021413-1ht1xm88 43 19 e e NN cord-021413-1ht1xm88 43 20 a a NNP cord-021413-1ht1xm88 43 21 n n NNP cord-021413-1ht1xm88 43 22 diameter diameter NN cord-021413-1ht1xm88 43 23 of of IN cord-021413-1ht1xm88 43 24 100 100 CD cord-021413-1ht1xm88 43 25 virions virion NNS cord-021413-1ht1xm88 43 26 of of IN cord-021413-1ht1xm88 43 27 purified purify VBN cord-021413-1ht1xm88 43 28 E e NN cord-021413-1ht1xm88 43 29 D d NN cord-021413-1ht1xm88 43 30 I i NN cord-021413-1ht1xm88 43 31 M m CD cord-021413-1ht1xm88 43 32 virus virus NN cord-021413-1ht1xm88 43 33 to to TO cord-021413-1ht1xm88 43 34 be be VB cord-021413-1ht1xm88 43 35 5 5 CD cord-021413-1ht1xm88 43 36 4 4 CD cord-021413-1ht1xm88 43 37 . . . cord-021413-1ht1xm88 44 1 4 4 LS cord-021413-1ht1xm88 44 2 ± ± CD cord-021413-1ht1xm88 44 3 2 2 CD cord-021413-1ht1xm88 44 4 n n NN cord-021413-1ht1xm88 44 5 m m NN cord-021413-1ht1xm88 44 6 . . . cord-021413-1ht1xm88 45 1 O o UH cord-021413-1ht1xm88 45 2 n n NN cord-021413-1ht1xm88 46 1 the the DT cord-021413-1ht1xm88 46 2 other other JJ cord-021413-1ht1xm88 46 3 h h NNP cord-021413-1ht1xm88 46 4 a a NNP cord-021413-1ht1xm88 46 5 n n NN cord-021413-1ht1xm88 46 6 d d NNP cord-021413-1ht1xm88 46 7 , , , cord-021413-1ht1xm88 46 8 Melnick Melnick NNP cord-021413-1ht1xm88 46 9 ( ( -LRB- cord-021413-1ht1xm88 46 10 1979 1979 CD cord-021413-1ht1xm88 46 11 ) ) -RRB- cord-021413-1ht1xm88 46 12 gives give VBZ cord-021413-1ht1xm88 46 13 about about RB cord-021413-1ht1xm88 46 14 50 50 CD cord-021413-1ht1xm88 46 15 % % NN cord-021413-1ht1xm88 46 16 is be VBZ cord-021413-1ht1xm88 46 17 lost lose VBN cord-021413-1ht1xm88 46 18 at at IN cord-021413-1ht1xm88 46 19 4X 4x CD cord-021413-1ht1xm88 46 20 for for IN cord-021413-1ht1xm88 46 21 24 24 CD cord-021413-1ht1xm88 46 22 hr hr NN cord-021413-1ht1xm88 46 23 or or CC cord-021413-1ht1xm88 46 24 at at IN cord-021413-1ht1xm88 46 25 37 37 CD cord-021413-1ht1xm88 46 26 T t NN cord-021413-1ht1xm88 46 27 for for IN cord-021413-1ht1xm88 46 28 1 1 CD cord-021413-1ht1xm88 46 29 hr hr NN cord-021413-1ht1xm88 46 30 . . . cord-021413-1ht1xm88 47 1 Although although IN cord-021413-1ht1xm88 47 2 some some DT cord-021413-1ht1xm88 47 3 infectivity infectivity NN cord-021413-1ht1xm88 47 4 ( ( -LRB- cord-021413-1ht1xm88 47 5 > > NFP cord-021413-1ht1xm88 47 6 0.05 0.05 CD cord-021413-1ht1xm88 47 7 % % NN cord-021413-1ht1xm88 47 8 ) ) -RRB- cord-021413-1ht1xm88 47 9 remains remain VBZ cord-021413-1ht1xm88 47 10 at at IN cord-021413-1ht1xm88 47 11 either either DT cord-021413-1ht1xm88 47 12 56 56 CD cord-021413-1ht1xm88 47 13 ° ° NN cord-021413-1ht1xm88 47 14 C c NN cord-021413-1ht1xm88 47 15 or or CC cord-021413-1ht1xm88 47 16 60 60 CD cord-021413-1ht1xm88 47 17 ° ° NN cord-021413-1ht1xm88 47 18 C c NN cord-021413-1ht1xm88 47 19 for for IN cord-021413-1ht1xm88 47 20 30 30 CD cord-021413-1ht1xm88 47 21 min min NN cord-021413-1ht1xm88 47 22 , , , cord-021413-1ht1xm88 47 23 it -PRON- PRP cord-021413-1ht1xm88 47 24 is be VBZ cord-021413-1ht1xm88 47 25 abolished abolish VBN cord-021413-1ht1xm88 47 26 at at IN cord-021413-1ht1xm88 47 27 70 70 CD cord-021413-1ht1xm88 47 28 T t NN cord-021413-1ht1xm88 47 29 for for IN cord-021413-1ht1xm88 47 30 15 15 CD cord-021413-1ht1xm88 47 31 min min NN cord-021413-1ht1xm88 47 32 ( ( -LRB- cord-021413-1ht1xm88 47 33 Cheever Cheever NNP cord-021413-1ht1xm88 47 34 and and CC cord-021413-1ht1xm88 47 35 Muel Muel NNP cord-021413-1ht1xm88 47 36 ler ler NNP cord-021413-1ht1xm88 47 37 , , , cord-021413-1ht1xm88 47 38 1947 1947 CD cord-021413-1ht1xm88 47 39 ; ; : cord-021413-1ht1xm88 47 40 Kraft Kraft NNP cord-021413-1ht1xm88 47 41 , , , cord-021413-1ht1xm88 47 42 1957 1957 CD cord-021413-1ht1xm88 47 43 Kraft Kraft NNP cord-021413-1ht1xm88 47 44 , , , cord-021413-1ht1xm88 47 45 , , , cord-021413-1ht1xm88 47 46 1962b 1962b CD cord-021413-1ht1xm88 47 47 . . . cord-021413-1ht1xm88 48 1 Much much JJ cord-021413-1ht1xm88 48 2 and and CC cord-021413-1ht1xm88 48 3 Zajac Zajac NNP cord-021413-1ht1xm88 48 4 ( ( -LRB- cord-021413-1ht1xm88 48 5 1972 1972 CD cord-021413-1ht1xm88 48 6 ) ) -RRB- cord-021413-1ht1xm88 48 7 found find VBD cord-021413-1ht1xm88 48 8 that that IN cord-021413-1ht1xm88 48 9 the the DT cord-021413-1ht1xm88 48 10 purified purify VBN cord-021413-1ht1xm88 48 11 virus virus NN cord-021413-1ht1xm88 48 12 is be VBZ cord-021413-1ht1xm88 48 13 unstable unstable JJ cord-021413-1ht1xm88 48 14 at at IN cord-021413-1ht1xm88 48 15 both both DT cord-021413-1ht1xm88 48 16 4 4 CD cord-021413-1ht1xm88 48 17 ° ° NNS cord-021413-1ht1xm88 48 18 and and CC cord-021413-1ht1xm88 48 19 -24''C -24''c NN cord-021413-1ht1xm88 48 20 for for IN cord-021413-1ht1xm88 48 21 2 2 CD cord-021413-1ht1xm88 48 22 weeks week NNS cord-021413-1ht1xm88 48 23 but but CC cord-021413-1ht1xm88 48 24 found find VBD cord-021413-1ht1xm88 48 25 that that IN cord-021413-1ht1xm88 48 26 at at IN cord-021413-1ht1xm88 48 27 -70 -70 NN cord-021413-1ht1xm88 48 28 ° ° NN cord-021413-1ht1xm88 48 29 C c NN cord-021413-1ht1xm88 48 30 infectivity infectivity NN cord-021413-1ht1xm88 48 31 is be VBZ cord-021413-1ht1xm88 48 32 retained retain VBN cord-021413-1ht1xm88 48 33 for for IN cord-021413-1ht1xm88 48 34 at at RB cord-021413-1ht1xm88 48 35 least least JJS cord-021413-1ht1xm88 48 36 4 4 CD cord-021413-1ht1xm88 48 37 weeks week NNS cord-021413-1ht1xm88 48 38 . . . cord-021413-1ht1xm88 49 1 c. c. NNP cord-021413-1ht1xm88 49 2 Ejfect Ejfect NNP cord-021413-1ht1xm88 49 3 of of IN cord-021413-1ht1xm88 49 4 Chemicals Chemicals NNPS cord-021413-1ht1xm88 49 5 . . . cord-021413-1ht1xm88 50 1 In in IN cord-021413-1ht1xm88 50 2 an an DT cord-021413-1ht1xm88 50 3 intestinal intestinal JJ cord-021413-1ht1xm88 50 4 filtrate filtrate NN cord-021413-1ht1xm88 50 5 , , , cord-021413-1ht1xm88 50 6 EDIM EDIM NNP cord-021413-1ht1xm88 50 7 virus virus NN cord-021413-1ht1xm88 50 8 titer titer NN cord-021413-1ht1xm88 50 9 is be VBZ cord-021413-1ht1xm88 50 10 not not RB cord-021413-1ht1xm88 50 11 significantly significantly RB cord-021413-1ht1xm88 50 12 reduced reduce VBN cord-021413-1ht1xm88 50 13 when when WRB cord-021413-1ht1xm88 50 14 held hold VBN cord-021413-1ht1xm88 50 15 in in IN cord-021413-1ht1xm88 50 16 ether ether NN cord-021413-1ht1xm88 50 17 or or CC cord-021413-1ht1xm88 50 18 0.1 0.1 CD cord-021413-1ht1xm88 50 19 % % NN cord-021413-1ht1xm88 50 20 sodium sodium NN cord-021413-1ht1xm88 50 21 deoxycholate deoxycholate NN cord-021413-1ht1xm88 50 22 at at IN cord-021413-1ht1xm88 50 23 4 4 CD cord-021413-1ht1xm88 50 24 ° ° NN cord-021413-1ht1xm88 50 25 C c NN cord-021413-1ht1xm88 50 26 for for IN cord-021413-1ht1xm88 50 27 24 24 CD cord-021413-1ht1xm88 50 28 hr hr NN cord-021413-1ht1xm88 50 29 ( ( -LRB- cord-021413-1ht1xm88 50 30 Kraft Kraft NNP cord-021413-1ht1xm88 50 31 , , , cord-021413-1ht1xm88 50 32 1962b 1962b CD cord-021413-1ht1xm88 50 33 ) ) -RRB- cord-021413-1ht1xm88 50 34 . . . cord-021413-1ht1xm88 51 1 According accord VBG cord-021413-1ht1xm88 51 2 to to IN cord-021413-1ht1xm88 51 3 Much much JJ cord-021413-1ht1xm88 51 4 and and CC cord-021413-1ht1xm88 51 5 Zajac Zajac NNP cord-021413-1ht1xm88 51 6 ( ( -LRB- cord-021413-1ht1xm88 51 7 1972 1972 CD cord-021413-1ht1xm88 51 8 ) ) -RRB- cord-021413-1ht1xm88 51 9 , , , cord-021413-1ht1xm88 51 10 the the DT cord-021413-1ht1xm88 51 11 purified purify VBN cord-021413-1ht1xm88 51 12 virus virus NN cord-021413-1ht1xm88 51 13 is be VBZ cord-021413-1ht1xm88 51 14 stable stable JJ cord-021413-1ht1xm88 51 15 in in IN cord-021413-1ht1xm88 51 16 20 20 CD cord-021413-1ht1xm88 51 17 % % NN cord-021413-1ht1xm88 51 18 ether ether NN cord-021413-1ht1xm88 51 19 , , , cord-021413-1ht1xm88 51 20 5 5 CD cord-021413-1ht1xm88 51 21 % % NN cord-021413-1ht1xm88 51 22 chloroform chloroform NN cord-021413-1ht1xm88 51 23 , , , cord-021413-1ht1xm88 51 24 or or CC cord-021413-1ht1xm88 51 25 0.1 0.1 CD cord-021413-1ht1xm88 51 26 % % NN cord-021413-1ht1xm88 51 27 sodium sodium NN cord-021413-1ht1xm88 51 28 deoxycholate deoxycholate NN cord-021413-1ht1xm88 51 29 at at IN cord-021413-1ht1xm88 51 30 4 4 CD cord-021413-1ht1xm88 51 31 ° ° NN cord-021413-1ht1xm88 51 32 C c NN cord-021413-1ht1xm88 51 33 for for IN cord-021413-1ht1xm88 51 34 1 1 CD cord-021413-1ht1xm88 51 35 hr hr NN cord-021413-1ht1xm88 51 36 and and CC cord-021413-1ht1xm88 51 37 , , , cord-021413-1ht1xm88 51 38 as as IN cord-021413-1ht1xm88 51 39 is be VBZ cord-021413-1ht1xm88 51 40 true true JJ cord-021413-1ht1xm88 51 41 for for IN cord-021413-1ht1xm88 51 42 other other JJ cord-021413-1ht1xm88 51 43 rotaviruses rotavirus NNS cord-021413-1ht1xm88 51 44 , , , cord-021413-1ht1xm88 51 45 is be VBZ cord-021413-1ht1xm88 51 46 resistant resistant JJ cord-021413-1ht1xm88 51 47 to to IN cord-021413-1ht1xm88 51 48 pancreatin pancreatin NNP cord-021413-1ht1xm88 51 49 . . . cord-021413-1ht1xm88 52 1 Ward Ward NNP cord-021413-1ht1xm88 52 2 and and CC cord-021413-1ht1xm88 52 3 Ashley Ashley NNP cord-021413-1ht1xm88 52 4 ( ( -LRB- cord-021413-1ht1xm88 52 5 1980a 1980a CD cord-021413-1ht1xm88 52 6 , , , cord-021413-1ht1xm88 52 7 b b LS cord-021413-1ht1xm88 52 8 ) ) -RRB- cord-021413-1ht1xm88 52 9 examined examine VBD cord-021413-1ht1xm88 52 10 the the DT cord-021413-1ht1xm88 52 11 effects effect NNS cord-021413-1ht1xm88 52 12 of of IN cord-021413-1ht1xm88 52 13 the the DT cord-021413-1ht1xm88 52 14 anionic anionic JJ cord-021413-1ht1xm88 52 15 detergent detergent NN cord-021413-1ht1xm88 52 16 sodium sodium NN cord-021413-1ht1xm88 52 17 dodecyl dodecyl NNP cord-021413-1ht1xm88 52 18 sulfate sulfate NNP cord-021413-1ht1xm88 52 19 and and CC cord-021413-1ht1xm88 52 20 of of IN cord-021413-1ht1xm88 52 21 the the DT cord-021413-1ht1xm88 52 22 chelating chelate VBG cord-021413-1ht1xm88 52 23 agent agent NN cord-021413-1ht1xm88 52 24 ethylenediaminetetraacetate ethylenediaminetetraacetate NNP cord-021413-1ht1xm88 52 25 on on IN cord-021413-1ht1xm88 52 26 purified purify VBN cord-021413-1ht1xm88 52 27 simian simian JJ cord-021413-1ht1xm88 52 28 virus virus NN cord-021413-1ht1xm88 52 29 and and CC cord-021413-1ht1xm88 52 30 determined determine VBD cord-021413-1ht1xm88 52 31 that that IN cord-021413-1ht1xm88 52 32 low low JJ cord-021413-1ht1xm88 52 33 concentrations concentration NNS cord-021413-1ht1xm88 52 34 and and CC cord-021413-1ht1xm88 52 35 mild mild JJ cord-021413-1ht1xm88 52 36 temper temper NN cord-021413-1ht1xm88 52 37 ature ature NN cord-021413-1ht1xm88 52 38 conditions condition NNS cord-021413-1ht1xm88 52 39 readily readily RB cord-021413-1ht1xm88 52 40 inactivated inactivate VBD cord-021413-1ht1xm88 52 41 the the DT cord-021413-1ht1xm88 52 42 agent agent NN cord-021413-1ht1xm88 52 43 . . . cord-021413-1ht1xm88 53 1 Both both DT cord-021413-1ht1xm88 53 2 chemicals chemical NNS cord-021413-1ht1xm88 53 3 modified modify VBD cord-021413-1ht1xm88 53 4 the the DT cord-021413-1ht1xm88 53 5 viral viral JJ cord-021413-1ht1xm88 53 6 capsid capsid NN cord-021413-1ht1xm88 53 7 to to TO cord-021413-1ht1xm88 53 8 prevent prevent VB cord-021413-1ht1xm88 53 9 adsoφtion adsoφtion NN cord-021413-1ht1xm88 53 10 of of IN cord-021413-1ht1xm88 53 11 the the DT cord-021413-1ht1xm88 53 12 inacti inacti NNP cord-021413-1ht1xm88 53 13 vated vate VBD cord-021413-1ht1xm88 53 14 virions virion NNS cord-021413-1ht1xm88 53 15 to to IN cord-021413-1ht1xm88 53 16 cells cell NNS cord-021413-1ht1xm88 53 17 . . . cord-021413-1ht1xm88 54 1 Indeed indeed RB cord-021413-1ht1xm88 54 2 , , , cord-021413-1ht1xm88 54 3 this this DT cord-021413-1ht1xm88 54 4 study study NN cord-021413-1ht1xm88 54 5 was be VBD cord-021413-1ht1xm88 54 6 the the DT cord-021413-1ht1xm88 54 7 outgrowth outgrowth NN cord-021413-1ht1xm88 54 8 of of IN cord-021413-1ht1xm88 54 9 a a DT cord-021413-1ht1xm88 54 10 need need NN cord-021413-1ht1xm88 54 11 to to TO cord-021413-1ht1xm88 54 12 determine determine VB cord-021413-1ht1xm88 54 13 the the DT cord-021413-1ht1xm88 54 14 survival survival NN cord-021413-1ht1xm88 54 15 of of IN cord-021413-1ht1xm88 54 16 enteric enteric JJ cord-021413-1ht1xm88 54 17 viruses virus NNS cord-021413-1ht1xm88 54 18 in in IN cord-021413-1ht1xm88 54 19 wastewater wastewater NN cord-021413-1ht1xm88 54 20 . . . cord-021413-1ht1xm88 55 1 It -PRON- PRP cord-021413-1ht1xm88 55 2 had have VBD cord-021413-1ht1xm88 55 3 been be VBN cord-021413-1ht1xm88 55 4 determined determine VBN cord-021413-1ht1xm88 55 5 that that IN cord-021413-1ht1xm88 55 6 wastewater wastewater NN cord-021413-1ht1xm88 55 7 sludge sludge NN cord-021413-1ht1xm88 55 8 reduced reduce VBD cord-021413-1ht1xm88 55 9 the the DT cord-021413-1ht1xm88 55 10 heat heat NN cord-021413-1ht1xm88 55 11 necessary necessary JJ cord-021413-1ht1xm88 55 12 for for IN cord-021413-1ht1xm88 55 13 simian simian JJ cord-021413-1ht1xm88 55 14 rotavirus rotavirus NN cord-021413-1ht1xm88 55 15 inactivation inactivation NN cord-021413-1ht1xm88 55 16 . . . cord-021413-1ht1xm88 56 1 Ionic ionic JJ cord-021413-1ht1xm88 56 2 detergents detergent NNS cord-021413-1ht1xm88 56 3 in in IN cord-021413-1ht1xm88 56 4 the the DT cord-021413-1ht1xm88 56 5 sludge sludge NN cord-021413-1ht1xm88 56 6 were be VBD cord-021413-1ht1xm88 56 7 identified identify VBN cord-021413-1ht1xm88 56 8 as as IN cord-021413-1ht1xm88 56 9 the the DT cord-021413-1ht1xm88 56 10 active active JJ cord-021413-1ht1xm88 56 11 components component NNS cord-021413-1ht1xm88 56 12 . . . cord-021413-1ht1xm88 57 1 Nonionic Nonionic NNP cord-021413-1ht1xm88 57 2 detergents detergent NNS cord-021413-1ht1xm88 57 3 did do VBD cord-021413-1ht1xm88 57 4 not not RB cord-021413-1ht1xm88 57 5 destabilize destabilize VB cord-021413-1ht1xm88 57 6 the the DT cord-021413-1ht1xm88 57 7 virus virus NN cord-021413-1ht1xm88 57 8 ; ; : cord-021413-1ht1xm88 57 9 further far RBR cord-021413-1ht1xm88 57 10 , , , cord-021413-1ht1xm88 57 11 these these DT cord-021413-1ht1xm88 57 12 com com NN cord-021413-1ht1xm88 57 13 pounds pound NNS cord-021413-1ht1xm88 57 14 protected protect VBD cord-021413-1ht1xm88 57 15 the the DT cord-021413-1ht1xm88 57 16 virus virus NN cord-021413-1ht1xm88 57 17 from from IN cord-021413-1ht1xm88 57 18 the the DT cord-021413-1ht1xm88 57 19 destabilizing destabilizing JJ cord-021413-1ht1xm88 57 20 effect effect NN cord-021413-1ht1xm88 57 21 of of IN cord-021413-1ht1xm88 57 22 sodium sodium NN cord-021413-1ht1xm88 57 23 dodecyl dodecyl NNP cord-021413-1ht1xm88 57 24 sulfate sulfate NN cord-021413-1ht1xm88 57 25 . . . cord-021413-1ht1xm88 58 1 Destabilization destabilization NN cord-021413-1ht1xm88 58 2 by by IN cord-021413-1ht1xm88 58 3 both both CC cord-021413-1ht1xm88 58 4 cationic cationic JJ cord-021413-1ht1xm88 58 5 and and CC cord-021413-1ht1xm88 58 6 anionic anionic JJ cord-021413-1ht1xm88 58 7 detergents detergent NNS cord-021413-1ht1xm88 58 8 was be VBD cord-021413-1ht1xm88 58 9 found find VBN cord-021413-1ht1xm88 58 10 to to TO cord-021413-1ht1xm88 58 11 be be VB cord-021413-1ht1xm88 58 12 dependent dependent JJ cord-021413-1ht1xm88 58 13 on on IN cord-021413-1ht1xm88 58 14 the the DT cord-021413-1ht1xm88 58 15 pH ph NN cord-021413-1ht1xm88 58 16 of of IN cord-021413-1ht1xm88 58 17 the the DT cord-021413-1ht1xm88 58 18 medium medium NN cord-021413-1ht1xm88 58 19 . . . cord-021413-1ht1xm88 59 1 A a DT cord-021413-1ht1xm88 59 2 systematic systematic JJ cord-021413-1ht1xm88 59 3 study study NN cord-021413-1ht1xm88 59 4 of of IN cord-021413-1ht1xm88 59 5 the the DT cord-021413-1ht1xm88 59 6 stability stability NN cord-021413-1ht1xm88 59 7 of of IN cord-021413-1ht1xm88 59 8 EDIM EDIM NNP cord-021413-1ht1xm88 59 9 virus virus NN cord-021413-1ht1xm88 59 10 to to IN cord-021413-1ht1xm88 59 11 extremes extreme NNS cord-021413-1ht1xm88 59 12 of of IN cord-021413-1ht1xm88 59 13 pH pH NNP cord-021413-1ht1xm88 59 14 has have VBZ cord-021413-1ht1xm88 59 15 not not RB cord-021413-1ht1xm88 59 16 been be VBN cord-021413-1ht1xm88 59 17 reported report VBN cord-021413-1ht1xm88 59 18 . . . cord-021413-1ht1xm88 60 1 Much much JJ cord-021413-1ht1xm88 60 2 and and CC cord-021413-1ht1xm88 60 3 Zajac Zajac NNP cord-021413-1ht1xm88 60 4 ( ( -LRB- cord-021413-1ht1xm88 60 5 1972 1972 CD cord-021413-1ht1xm88 60 6 ) ) -RRB- cord-021413-1ht1xm88 60 7 Kraft Kraft NNP cord-021413-1ht1xm88 60 8 ( ( -LRB- cord-021413-1ht1xm88 60 9 1966 1966 CD cord-021413-1ht1xm88 60 10 ) ) -RRB- cord-021413-1ht1xm88 60 11 _SP cord-021413-1ht1xm88 61 1 Replication replication NN cord-021413-1ht1xm88 61 2 of of IN cord-021413-1ht1xm88 61 3 EDIM EDIM NNP cord-021413-1ht1xm88 61 4 virus virus NN cord-021413-1ht1xm88 61 5 occurs occur VBZ cord-021413-1ht1xm88 61 6 in in IN cord-021413-1ht1xm88 61 7 epithelial epithelial JJ cord-021413-1ht1xm88 61 8 cells cell NNS cord-021413-1ht1xm88 61 9 of of IN cord-021413-1ht1xm88 61 10 the the DT cord-021413-1ht1xm88 61 11 villi villi NN cord-021413-1ht1xm88 61 12 of of IN cord-021413-1ht1xm88 61 13 the the DT cord-021413-1ht1xm88 61 14 small small JJ cord-021413-1ht1xm88 61 15 intestine intestine NN cord-021413-1ht1xm88 61 16 . . . cord-021413-1ht1xm88 62 1 In in IN cord-021413-1ht1xm88 62 2 electron electron NN cord-021413-1ht1xm88 62 3 micrographs micrograph NNS cord-021413-1ht1xm88 62 4 , , , cord-021413-1ht1xm88 62 5 Kraft Kraft NNP cord-021413-1ht1xm88 62 6 ( ( -LRB- cord-021413-1ht1xm88 62 7 1967 1967 CD cord-021413-1ht1xm88 62 8 ) ) -RRB- cord-021413-1ht1xm88 62 9 , , , cord-021413-1ht1xm88 62 10 Banfield Banfield NNP cord-021413-1ht1xm88 62 11 etal etal NNP cord-021413-1ht1xm88 62 12 . . . cord-021413-1ht1xm88 63 1 ( ( -LRB- cord-021413-1ht1xm88 63 2 1968 1968 CD cord-021413-1ht1xm88 63 3 ) ) -RRB- cord-021413-1ht1xm88 63 4 , , , cord-021413-1ht1xm88 63 5 and and CC cord-021413-1ht1xm88 63 6 Holmes Holmes NNP cord-021413-1ht1xm88 63 7 etal etal NNP cord-021413-1ht1xm88 63 8 . . . cord-021413-1ht1xm88 64 1 ( ( -LRB- cord-021413-1ht1xm88 64 2 1975 1975 CD cord-021413-1ht1xm88 64 3 ) ) -RRB- cord-021413-1ht1xm88 64 4 demonstrated demonstrate VBD cord-021413-1ht1xm88 64 5 replication replication NN cord-021413-1ht1xm88 64 6 by by IN cord-021413-1ht1xm88 64 7 budding bud VBG cord-021413-1ht1xm88 64 8 in in IN cord-021413-1ht1xm88 64 9 distended distended JJ cord-021413-1ht1xm88 64 10 cistemae cistemae NN cord-021413-1ht1xm88 64 11 of of IN cord-021413-1ht1xm88 64 12 the the DT cord-021413-1ht1xm88 64 13 endoplasmic endoplasmic NN cord-021413-1ht1xm88 64 14 reticulum reticulum NN cord-021413-1ht1xm88 64 15 . . . cord-021413-1ht1xm88 65 1 The the DT cord-021413-1ht1xm88 65 2 significance significance NN cord-021413-1ht1xm88 65 3 of of IN cord-021413-1ht1xm88 65 4 intracytoplas intracytopla NNS cord-021413-1ht1xm88 65 5 mic mic NNP cord-021413-1ht1xm88 65 6 and and CC cord-021413-1ht1xm88 65 7 intranuclear intranuclear NNP cord-021413-1ht1xm88 65 8 tubular tubular JJ cord-021413-1ht1xm88 65 9 structures structure NNS cord-021413-1ht1xm88 65 10 encountered encounter VBN cord-021413-1ht1xm88 65 11 is be VBZ cord-021413-1ht1xm88 65 12 not not RB cord-021413-1ht1xm88 65 13 clear clear JJ cord-021413-1ht1xm88 65 14 . . . cord-021413-1ht1xm88 66 1 Using use VBG cord-021413-1ht1xm88 66 2 direct direct JJ cord-021413-1ht1xm88 66 3 immunofluorescence immunofluorescence NN cord-021413-1ht1xm88 66 4 , , , cord-021413-1ht1xm88 66 5 Wilsnack Wilsnack NNP cord-021413-1ht1xm88 66 6 et et NNP cord-021413-1ht1xm88 66 7 al al NNP cord-021413-1ht1xm88 66 8 . . . cord-021413-1ht1xm88 67 1 ( ( -LRB- cord-021413-1ht1xm88 67 2 1969 1969 CD cord-021413-1ht1xm88 67 3 ) ) -RRB- cord-021413-1ht1xm88 67 4 found find VBD cord-021413-1ht1xm88 67 5 that that IN cord-021413-1ht1xm88 67 6 EDIM EDIM NNP cord-021413-1ht1xm88 67 7 virus virus NN cord-021413-1ht1xm88 67 8 antigen antigen NN cord-021413-1ht1xm88 67 9 in in IN cord-021413-1ht1xm88 67 10 infant infant NN cord-021413-1ht1xm88 67 11 mice mouse NNS cord-021413-1ht1xm88 67 12 is be VBZ cord-021413-1ht1xm88 67 13 limited limit VBN cord-021413-1ht1xm88 67 14 to to IN cord-021413-1ht1xm88 67 15 the the DT cord-021413-1ht1xm88 67 16 cytoplasm cytoplasm NN cord-021413-1ht1xm88 67 17 of of IN cord-021413-1ht1xm88 67 18 the the DT cord-021413-1ht1xm88 67 19 villous villous JJ cord-021413-1ht1xm88 67 20 epithelium epithelium NN cord-021413-1ht1xm88 67 21 from from IN cord-021413-1ht1xm88 67 22 the the DT cord-021413-1ht1xm88 67 23 duodenum duodenum NN cord-021413-1ht1xm88 67 24 to to IN cord-021413-1ht1xm88 67 25 the the DT cord-021413-1ht1xm88 67 26 colon colon NN cord-021413-1ht1xm88 67 27 and and CC cord-021413-1ht1xm88 67 28 is be VBZ cord-021413-1ht1xm88 67 29 detectable detectable JJ cord-021413-1ht1xm88 67 30 within within IN cord-021413-1ht1xm88 67 31 48 48 CD cord-021413-1ht1xm88 67 32 hr hr NN cord-021413-1ht1xm88 67 33 after after IN cord-021413-1ht1xm88 67 34 peroral peroral JJ cord-021413-1ht1xm88 67 35 inoculation inoculation NN cord-021413-1ht1xm88 67 36 . . . cord-021413-1ht1xm88 68 1 Stainable stainable JJ cord-021413-1ht1xm88 68 2 virus virus NN cord-021413-1ht1xm88 68 3 was be VBD cord-021413-1ht1xm88 68 4 also also RB cord-021413-1ht1xm88 68 5 seen see VBN cord-021413-1ht1xm88 68 6 in in IN cord-021413-1ht1xm88 68 7 the the DT cord-021413-1ht1xm88 68 8 intestines intestine NNS cord-021413-1ht1xm88 68 9 of of IN cord-021413-1ht1xm88 68 10 contact contact NN cord-021413-1ht1xm88 68 11 infant infant NN cord-021413-1ht1xm88 68 12 mice mouse NNS cord-021413-1ht1xm88 68 13 without without IN cord-021413-1ht1xm88 68 14 necessarily necessarily RB cord-021413-1ht1xm88 68 15 causing cause VBG cord-021413-1ht1xm88 68 16 clinical clinical JJ cord-021413-1ht1xm88 68 17 signs sign NNS cord-021413-1ht1xm88 68 18 to to TO cord-021413-1ht1xm88 68 19 appear appear VB cord-021413-1ht1xm88 68 20 . . . cord-021413-1ht1xm88 69 1 The the DT cord-021413-1ht1xm88 69 2 virus virus NN cord-021413-1ht1xm88 69 3 could could MD cord-021413-1ht1xm88 69 4 not not RB cord-021413-1ht1xm88 69 5 be be VB cord-021413-1ht1xm88 69 6 stained stain VBN cord-021413-1ht1xm88 69 7 in in IN cord-021413-1ht1xm88 69 8 the the DT cord-021413-1ht1xm88 69 9 stomach stomach NN cord-021413-1ht1xm88 69 10 or or CC cord-021413-1ht1xm88 69 11 liver liver NN cord-021413-1ht1xm88 69 12 of of IN cord-021413-1ht1xm88 69 13 mice mouse NNS cord-021413-1ht1xm88 69 14 infected infect VBN cord-021413-1ht1xm88 69 15 either either CC cord-021413-1ht1xm88 69 16 naturally naturally RB cord-021413-1ht1xm88 69 17 or or CC cord-021413-1ht1xm88 69 18 experimentally experimentally RB cord-021413-1ht1xm88 69 19 . . . cord-021413-1ht1xm88 70 1 Kraft Kraft NNP cord-021413-1ht1xm88 70 2 ( ( -LRB- cord-021413-1ht1xm88 70 3 1958 1958 CD cord-021413-1ht1xm88 70 4 ) ) -RRB- cord-021413-1ht1xm88 70 5 studied study VBD cord-021413-1ht1xm88 70 6 the the DT cord-021413-1ht1xm88 70 7 distribution distribution NN cord-021413-1ht1xm88 70 8 of of IN cord-021413-1ht1xm88 70 9 infectious infectious JJ cord-021413-1ht1xm88 70 10 EDIM edim NN cord-021413-1ht1xm88 70 11 virus virus NN cord-021413-1ht1xm88 70 12 in in IN cord-021413-1ht1xm88 70 13 3-day 3-day JJ cord-021413-1ht1xm88 70 14 - - HYPH cord-021413-1ht1xm88 70 15 old old JJ cord-021413-1ht1xm88 70 16 mice mouse NNS cord-021413-1ht1xm88 70 17 following follow VBG cord-021413-1ht1xm88 70 18 peroral peroral JJ cord-021413-1ht1xm88 70 19 inoculation inoculation NN cord-021413-1ht1xm88 70 20 . . . cord-021413-1ht1xm88 71 1 At at IN cord-021413-1ht1xm88 71 2 3 3 CD cord-021413-1ht1xm88 71 3 hr hr NN cord-021413-1ht1xm88 71 4 , , , cord-021413-1ht1xm88 71 5 virus virus NN cord-021413-1ht1xm88 71 6 was be VBD cord-021413-1ht1xm88 71 7 detected detect VBN cord-021413-1ht1xm88 71 8 in in IN cord-021413-1ht1xm88 71 9 the the DT cord-021413-1ht1xm88 71 10 stomach stomach NN cord-021413-1ht1xm88 71 11 and and CC cord-021413-1ht1xm88 71 12 small small JJ cord-021413-1ht1xm88 71 13 and and CC cord-021413-1ht1xm88 71 14 large large JJ cord-021413-1ht1xm88 71 15 intes inte NNS cord-021413-1ht1xm88 71 16 tines tine NNS cord-021413-1ht1xm88 71 17 ( ( -LRB- cord-021413-1ht1xm88 71 18 the the DT cord-021413-1ht1xm88 71 19 cecum cecum NN cord-021413-1ht1xm88 71 20 was be VBD cord-021413-1ht1xm88 71 21 not not RB cord-021413-1ht1xm88 71 22 tested test VBN cord-021413-1ht1xm88 71 23 ) ) -RRB- cord-021413-1ht1xm88 71 24 and and CC cord-021413-1ht1xm88 71 25 could could MD cord-021413-1ht1xm88 71 26 not not RB cord-021413-1ht1xm88 71 27 be be VB cord-021413-1ht1xm88 71 28 recovered recover VBN cord-021413-1ht1xm88 71 29 from from IN cord-021413-1ht1xm88 71 30 the the DT cord-021413-1ht1xm88 71 31 lungs lung NNS cord-021413-1ht1xm88 71 32 , , , cord-021413-1ht1xm88 71 33 liver liver NN cord-021413-1ht1xm88 71 34 , , , cord-021413-1ht1xm88 71 35 spleen spleen NN cord-021413-1ht1xm88 71 36 , , , cord-021413-1ht1xm88 71 37 kidney kidney NN cord-021413-1ht1xm88 71 38 , , , cord-021413-1ht1xm88 71 39 or or CC cord-021413-1ht1xm88 71 40 blood blood NN cord-021413-1ht1xm88 71 41 . . . cord-021413-1ht1xm88 72 1 At at IN cord-021413-1ht1xm88 72 2 22 22 CD cord-021413-1ht1xm88 72 3 hr hr NN cord-021413-1ht1xm88 72 4 , , , cord-021413-1ht1xm88 72 5 all all PDT cord-021413-1ht1xm88 72 6 those those DT cord-021413-1ht1xm88 72 7 tissues tissue NNS cord-021413-1ht1xm88 72 8 were be VBD cord-021413-1ht1xm88 72 9 positive positive JJ cord-021413-1ht1xm88 72 10 except except IN cord-021413-1ht1xm88 72 11 for for IN cord-021413-1ht1xm88 72 12 the the DT cord-021413-1ht1xm88 72 13 kidney kidney NN cord-021413-1ht1xm88 72 14 . . . cord-021413-1ht1xm88 73 1 The the DT cord-021413-1ht1xm88 73 2 bladder bladder NN cord-021413-1ht1xm88 73 3 and and CC cord-021413-1ht1xm88 73 4 urine urine NN cord-021413-1ht1xm88 73 5 , , , cord-021413-1ht1xm88 73 6 as as RB cord-021413-1ht1xm88 73 7 well well RB cord-021413-1ht1xm88 73 8 as as IN cord-021413-1ht1xm88 73 9 the the DT cord-021413-1ht1xm88 73 10 brain brain NN cord-021413-1ht1xm88 73 11 , , , cord-021413-1ht1xm88 73 12 were be VBD cord-021413-1ht1xm88 73 13 also also RB cord-021413-1ht1xm88 73 14 devoid devoid JJ cord-021413-1ht1xm88 73 15 of of IN cord-021413-1ht1xm88 73 16 the the DT cord-021413-1ht1xm88 73 17 agent agent NN cord-021413-1ht1xm88 73 18 , , , cord-021413-1ht1xm88 73 19 but but CC cord-021413-1ht1xm88 73 20 at at IN cord-021413-1ht1xm88 73 21 30 30 CD cord-021413-1ht1xm88 73 22 hr hr NN cord-021413-1ht1xm88 73 23 , , , cord-021413-1ht1xm88 73 24 these these DT cord-021413-1ht1xm88 73 25 too too RB cord-021413-1ht1xm88 73 26 were be VBD cord-021413-1ht1xm88 73 27 positive positive JJ cord-021413-1ht1xm88 73 28 . . . cord-021413-1ht1xm88 74 1 At at IN cord-021413-1ht1xm88 74 2 72 72 CD cord-021413-1ht1xm88 74 3 hr hr NN cord-021413-1ht1xm88 74 4 , , , cord-021413-1ht1xm88 74 5 the the DT cord-021413-1ht1xm88 74 6 liver liver NN cord-021413-1ht1xm88 74 7 , , , cord-021413-1ht1xm88 74 8 spleen spleen NN cord-021413-1ht1xm88 74 9 , , , cord-021413-1ht1xm88 74 10 kidney kidney NN cord-021413-1ht1xm88 74 11 , , , cord-021413-1ht1xm88 74 12 and and CC cord-021413-1ht1xm88 74 13 intestines intestine NNS cord-021413-1ht1xm88 74 14 yielded yield VBD cord-021413-1ht1xm88 74 15 virus virus NN cord-021413-1ht1xm88 74 16 , , , cord-021413-1ht1xm88 74 17 but but CC cord-021413-1ht1xm88 74 18 the the DT cord-021413-1ht1xm88 74 19 brain brain NN cord-021413-1ht1xm88 74 20 was be VBD cord-021413-1ht1xm88 74 21 negative negative JJ cord-021413-1ht1xm88 74 22 . . . cord-021413-1ht1xm88 75 1 The the DT cord-021413-1ht1xm88 75 2 blood blood NN cord-021413-1ht1xm88 75 3 , , , cord-021413-1ht1xm88 75 4 stomach stomach NN cord-021413-1ht1xm88 75 5 , , , cord-021413-1ht1xm88 75 6 lungs lung NNS cord-021413-1ht1xm88 75 7 , , , cord-021413-1ht1xm88 75 8 bladder bladder NN cord-021413-1ht1xm88 75 9 , , , cord-021413-1ht1xm88 75 10 and and CC cord-021413-1ht1xm88 75 11 urine urine NN cord-021413-1ht1xm88 75 12 were be VBD cord-021413-1ht1xm88 75 13 not not RB cord-021413-1ht1xm88 75 14 tested test VBN cord-021413-1ht1xm88 75 15 at at IN cord-021413-1ht1xm88 75 16 that that DT cord-021413-1ht1xm88 75 17 interval interval NN cord-021413-1ht1xm88 75 18 . . . cord-021413-1ht1xm88 76 1 At at IN cord-021413-1ht1xm88 76 2 6 6 CD cord-021413-1ht1xm88 76 3 days day NNS cord-021413-1ht1xm88 76 4 , , , cord-021413-1ht1xm88 76 5 blood blood NN cord-021413-1ht1xm88 76 6 , , , cord-021413-1ht1xm88 76 7 liver liver NN cord-021413-1ht1xm88 76 8 , , , cord-021413-1ht1xm88 76 9 and and CC cord-021413-1ht1xm88 76 10 intestines intestine NNS cord-021413-1ht1xm88 76 11 , , , cord-021413-1ht1xm88 76 12 the the DT cord-021413-1ht1xm88 76 13 only only JJ cord-021413-1ht1xm88 76 14 tissues tissue NNS cord-021413-1ht1xm88 76 15 examined examine VBN cord-021413-1ht1xm88 76 16 , , , cord-021413-1ht1xm88 76 17 still still RB cord-021413-1ht1xm88 76 18 contained contain VBD cord-021413-1ht1xm88 76 19 virus virus NN cord-021413-1ht1xm88 76 20 . . . cord-021413-1ht1xm88 77 1 Ingested ingest VBN cord-021413-1ht1xm88 77 2 virus virus NN cord-021413-1ht1xm88 77 3 from from IN cord-021413-1ht1xm88 77 4 a a DT cord-021413-1ht1xm88 77 5 diarrheal diarrheal JJ cord-021413-1ht1xm88 77 6 litter litter NN cord-021413-1ht1xm88 77 7 brings bring VBZ cord-021413-1ht1xm88 77 8 about about RP cord-021413-1ht1xm88 77 9 an an DT cord-021413-1ht1xm88 77 10 active active JJ cord-021413-1ht1xm88 77 11 infection infection NN cord-021413-1ht1xm88 77 12 in in IN cord-021413-1ht1xm88 77 13 the the DT cord-021413-1ht1xm88 77 14 nursing nursing NN cord-021413-1ht1xm88 77 15 dam dam NN cord-021413-1ht1xm88 77 16 that that WDT cord-021413-1ht1xm88 77 17 previously previously RB cord-021413-1ht1xm88 77 18 had have VBD cord-021413-1ht1xm88 77 19 been be VBN cord-021413-1ht1xm88 77 20 nondiarrheal nondiarrheal NN cord-021413-1ht1xm88 77 21 herself -PRON- PRP cord-021413-1ht1xm88 77 22 and and CC cord-021413-1ht1xm88 77 23 had have VBD cord-021413-1ht1xm88 77 24 had have VBN cord-021413-1ht1xm88 77 25 only only JJ cord-021413-1ht1xm88 77 26 nondiarrheal nondiarrheal JJ cord-021413-1ht1xm88 77 27 litters litter NNS cord-021413-1ht1xm88 77 28 ( ( -LRB- cord-021413-1ht1xm88 77 29 Kraft Kraft NNP cord-021413-1ht1xm88 77 30 , , , cord-021413-1ht1xm88 77 31 1958 1958 CD cord-021413-1ht1xm88 77 32 ) ) -RRB- cord-021413-1ht1xm88 77 33 . . . cord-021413-1ht1xm88 78 1 Blood blood NN cord-021413-1ht1xm88 78 2 , , , cord-021413-1ht1xm88 78 3 liver liver NN cord-021413-1ht1xm88 78 4 , , , cord-021413-1ht1xm88 78 5 spleen spleen NNS cord-021413-1ht1xm88 78 6 , , , cord-021413-1ht1xm88 78 7 and and CC cord-021413-1ht1xm88 78 8 feces fece NNS cord-021413-1ht1xm88 78 9 all all DT cord-021413-1ht1xm88 78 10 contain contain VBP cord-021413-1ht1xm88 78 11 infectious infectious JJ cord-021413-1ht1xm88 78 12 virus virus NN cord-021413-1ht1xm88 78 13 in in IN cord-021413-1ht1xm88 78 14 the the DT cord-021413-1ht1xm88 78 15 dam dam NN cord-021413-1ht1xm88 78 16 1 1 CD cord-021413-1ht1xm88 78 17 week week NN cord-021413-1ht1xm88 78 18 after after IN cord-021413-1ht1xm88 78 19 her -PRON- PRP$ cord-021413-1ht1xm88 78 20 litter litter NN cord-021413-1ht1xm88 78 21 is be VBZ cord-021413-1ht1xm88 78 22 given give VBN cord-021413-1ht1xm88 78 23 virus virus NN cord-021413-1ht1xm88 78 24 perorally perorally RB cord-021413-1ht1xm88 78 25 as as IN cord-021413-1ht1xm88 78 26 an an DT cord-021413-1ht1xm88 78 27 intestinal intestinal JJ cord-021413-1ht1xm88 78 28 filtrate filtrate NN cord-021413-1ht1xm88 78 29 . . . cord-021413-1ht1xm88 79 1 Later later RBR cord-021413-1ht1xm88 79 2 , , , cord-021413-1ht1xm88 79 3 Kraft Kraft NNP cord-021413-1ht1xm88 79 4 ( ( -LRB- cord-021413-1ht1xm88 79 5 1961 1961 CD cord-021413-1ht1xm88 79 6 ) ) -RRB- cord-021413-1ht1xm88 79 7 determined determine VBD cord-021413-1ht1xm88 79 8 that that IN cord-021413-1ht1xm88 79 9 adult adult NN cord-021413-1ht1xm88 79 10 male male JJ cord-021413-1ht1xm88 79 11 mice mouse NNS cord-021413-1ht1xm88 79 12 can can MD cord-021413-1ht1xm88 79 13 also also RB cord-021413-1ht1xm88 79 14 be be VB cord-021413-1ht1xm88 79 15 intestinal intestinal JJ cord-021413-1ht1xm88 79 16 carriers carrier NNS cord-021413-1ht1xm88 79 17 for for IN cord-021413-1ht1xm88 79 18 at at RB cord-021413-1ht1xm88 79 19 least least RBS cord-021413-1ht1xm88 79 20 17 17 CD cord-021413-1ht1xm88 79 21 days day NNS cord-021413-1ht1xm88 79 22 after after IN cord-021413-1ht1xm88 79 23 a a DT cord-021413-1ht1xm88 79 24 single single JJ cord-021413-1ht1xm88 79 25 peroral peroral JJ cord-021413-1ht1xm88 79 26 exposure exposure NN cord-021413-1ht1xm88 79 27 . . . cord-021413-1ht1xm88 80 1 With with IN cord-021413-1ht1xm88 80 2 regard regard NN cord-021413-1ht1xm88 80 3 to to IN cord-021413-1ht1xm88 80 4 the the DT cord-021413-1ht1xm88 80 5 mechanism mechanism NN cord-021413-1ht1xm88 80 6 of of IN cord-021413-1ht1xm88 80 7 cell cell NN cord-021413-1ht1xm88 80 8 penetration penetration NN cord-021413-1ht1xm88 80 9 . . . cord-021413-1ht1xm88 81 1 Holmes Holmes NNP cord-021413-1ht1xm88 81 2 et et NNP cord-021413-1ht1xm88 81 3 al al NNP cord-021413-1ht1xm88 81 4 . . . cord-021413-1ht1xm88 82 1 ( ( -LRB- cord-021413-1ht1xm88 82 2 1976 1976 CD cord-021413-1ht1xm88 82 3 ) ) -RRB- cord-021413-1ht1xm88 82 4 proposed propose VBD cord-021413-1ht1xm88 82 5 that that IN cord-021413-1ht1xm88 82 6 lactase lactase NN cord-021413-1ht1xm88 82 7 of of IN cord-021413-1ht1xm88 82 8 the the DT cord-021413-1ht1xm88 82 9 villous villous NNP cord-021413-1ht1xm88 82 10 brush brush NNP cord-021413-1ht1xm88 82 11 border border NN cord-021413-1ht1xm88 82 12 of of IN cord-021413-1ht1xm88 82 13 the the DT cord-021413-1ht1xm88 82 14 intestine intestine NN cord-021413-1ht1xm88 82 15 may may MD cord-021413-1ht1xm88 82 16 be be VB cord-021413-1ht1xm88 82 17 the the DT cord-021413-1ht1xm88 82 18 receptor receptor NN cord-021413-1ht1xm88 82 19 that that WDT cord-021413-1ht1xm88 82 20 uncoats uncoat VBZ cord-021413-1ht1xm88 82 21 the the DT cord-021413-1ht1xm88 82 22 rotavirus rotavirus JJ cord-021413-1ht1xm88 82 23 virion virion NN cord-021413-1ht1xm88 82 24 by by IN cord-021413-1ht1xm88 82 25 attacking attack VBG cord-021413-1ht1xm88 82 26 the the DT cord-021413-1ht1xm88 82 27 glycolysated glycolysate VBN cord-021413-1ht1xm88 82 28 polypeptides polypeptide NNS cord-021413-1ht1xm88 82 29 of of IN cord-021413-1ht1xm88 82 30 the the DT cord-021413-1ht1xm88 82 31 outer outer JJ cord-021413-1ht1xm88 82 32 capsid capsid NN cord-021413-1ht1xm88 82 33 . . . cord-021413-1ht1xm88 83 1 In in IN cord-021413-1ht1xm88 83 2 addition addition NN cord-021413-1ht1xm88 83 3 , , , cord-021413-1ht1xm88 83 4 pancreatic pancreatic NN cord-021413-1ht1xm88 83 5 enzymes enzyme NNS cord-021413-1ht1xm88 83 6 within within IN cord-021413-1ht1xm88 83 7 the the DT cord-021413-1ht1xm88 83 8 lumen lumen NN cord-021413-1ht1xm88 83 9 may may MD cord-021413-1ht1xm88 83 10 also also RB cord-021413-1ht1xm88 83 11 be be VB cord-021413-1ht1xm88 83 12 instrumental instrumental JJ cord-021413-1ht1xm88 83 13 in in IN cord-021413-1ht1xm88 83 14 the the DT cord-021413-1ht1xm88 83 15 infectious infectious JJ cord-021413-1ht1xm88 83 16 process process NN cord-021413-1ht1xm88 83 17 ( ( -LRB- cord-021413-1ht1xm88 83 18 see see VB cord-021413-1ht1xm88 83 19 Section Section NNP cord-021413-1ht1xm88 83 20 II II NNP cord-021413-1ht1xm88 83 21 , , , cord-021413-1ht1xm88 83 22 B,6 B,6 NNP cord-021413-1ht1xm88 83 23 ) ) -RRB- cord-021413-1ht1xm88 83 24 . . . cord-021413-1ht1xm88 84 1 The the DT cord-021413-1ht1xm88 84 2 question question NN cord-021413-1ht1xm88 84 3 of of IN cord-021413-1ht1xm88 84 4 cofactors cofactor NNS cord-021413-1ht1xm88 84 5 that that WDT cord-021413-1ht1xm88 84 6 might may MD cord-021413-1ht1xm88 84 7 enhance enhance VB cord-021413-1ht1xm88 84 8 pathogenicity pathogenicity NN cord-021413-1ht1xm88 84 9 or or CC cord-021413-1ht1xm88 84 10 of of IN cord-021413-1ht1xm88 84 11 interfering interfere VBG cord-021413-1ht1xm88 84 12 substances substance NNS cord-021413-1ht1xm88 84 13 , , , cord-021413-1ht1xm88 84 14 in in IN cord-021413-1ht1xm88 84 15 addition addition NN cord-021413-1ht1xm88 84 16 to to IN cord-021413-1ht1xm88 84 17 antibodies antibody NNS cord-021413-1ht1xm88 84 18 , , , cord-021413-1ht1xm88 84 19 that that WDT cord-021413-1ht1xm88 84 20 might may MD cord-021413-1ht1xm88 84 21 inhibit inhibit VB cord-021413-1ht1xm88 84 22 EDIM EDIM NNP cord-021413-1ht1xm88 84 23 virus virus NN cord-021413-1ht1xm88 84 24 replication replication NN cord-021413-1ht1xm88 84 25 is be VBZ cord-021413-1ht1xm88 84 26 open open JJ cord-021413-1ht1xm88 84 27 . . . cord-021413-1ht1xm88 85 1 Kraft Kraft NNP cord-021413-1ht1xm88 85 2 ( ( -LRB- cord-021413-1ht1xm88 85 3 1958 1958 CD cord-021413-1ht1xm88 85 4 ) ) -RRB- cord-021413-1ht1xm88 85 5 found find VBD cord-021413-1ht1xm88 85 6 increased increase VBN cord-021413-1ht1xm88 85 7 numbers number NNS cord-021413-1ht1xm88 85 8 of of IN cord-021413-1ht1xm88 85 9 Clostridium clostridium NN cord-021413-1ht1xm88 85 10 tertium tertium NN cord-021413-1ht1xm88 85 11 in in IN cord-021413-1ht1xm88 85 12 the the DT cord-021413-1ht1xm88 85 13 intes intes NNPS cord-021413-1ht1xm88 85 14 tine tine NN cord-021413-1ht1xm88 85 15 of of IN cord-021413-1ht1xm88 85 16 diarrheal diarrheal JJ cord-021413-1ht1xm88 85 17 animals animal NNS cord-021413-1ht1xm88 85 18 , , , cord-021413-1ht1xm88 85 19 and and CC cord-021413-1ht1xm88 85 20 Pappenheimer Pappenheimer NNP cord-021413-1ht1xm88 85 21 and and CC cord-021413-1ht1xm88 85 22 Enders Enders NNP cord-021413-1ht1xm88 85 23 ( ( -LRB- cord-021413-1ht1xm88 85 24 1947 1947 CD cord-021413-1ht1xm88 85 25 ) ) -RRB- cord-021413-1ht1xm88 85 26 remarked remark VBD cord-021413-1ht1xm88 85 27 on on IN cord-021413-1ht1xm88 85 28 the the DT cord-021413-1ht1xm88 85 29 persistent persistent JJ cord-021413-1ht1xm88 85 30 presence presence NN cord-021413-1ht1xm88 85 31 of of IN cord-021413-1ht1xm88 85 32 ' ' '' cord-021413-1ht1xm88 85 33 ' ' `` cord-021413-1ht1xm88 85 34 coccoid coccoid JJ cord-021413-1ht1xm88 85 35 bodies body NNS cord-021413-1ht1xm88 85 36 " " '' cord-021413-1ht1xm88 85 37 in in IN cord-021413-1ht1xm88 85 38 the the DT cord-021413-1ht1xm88 85 39 intestines intestine NNS cord-021413-1ht1xm88 85 40 of of IN cord-021413-1ht1xm88 85 41 diarrheal diarrheal JJ cord-021413-1ht1xm88 85 42 animals animal NNS cord-021413-1ht1xm88 85 43 as as IN cord-021413-1ht1xm88 85 44 seen see VBN cord-021413-1ht1xm88 85 45 by by IN cord-021413-1ht1xm88 85 46 light light JJ cord-021413-1ht1xm88 85 47 microscopy microscopy NNS cord-021413-1ht1xm88 85 48 . . . cord-021413-1ht1xm88 86 1 In in IN cord-021413-1ht1xm88 86 2 both both DT cord-021413-1ht1xm88 86 3 instances instance NNS cord-021413-1ht1xm88 86 4 , , , cord-021413-1ht1xm88 86 5 these these DT cord-021413-1ht1xm88 86 6 may may MD cord-021413-1ht1xm88 86 7 be be VB cord-021413-1ht1xm88 86 8 considered consider VBN cord-021413-1ht1xm88 86 9 opportunistic opportunistic JJ cord-021413-1ht1xm88 86 10 or or CC cord-021413-1ht1xm88 86 11 ganisms ganism NNS cord-021413-1ht1xm88 86 12 . . . cord-021413-1ht1xm88 87 1 Their -PRON- PRP$ cord-021413-1ht1xm88 87 2 effect effect NN cord-021413-1ht1xm88 87 3 on on IN cord-021413-1ht1xm88 87 4 the the DT cord-021413-1ht1xm88 87 5 severity severity NN cord-021413-1ht1xm88 87 6 of of IN cord-021413-1ht1xm88 87 7 the the DT cord-021413-1ht1xm88 87 8 clinical clinical JJ cord-021413-1ht1xm88 87 9 disease disease NN cord-021413-1ht1xm88 87 10 is be VBZ cord-021413-1ht1xm88 87 11 unknown unknown JJ cord-021413-1ht1xm88 87 12 , , , cord-021413-1ht1xm88 87 13 however however RB cord-021413-1ht1xm88 87 14 . . . cord-021413-1ht1xm88 88 1 One one CD cord-021413-1ht1xm88 88 2 report report NN cord-021413-1ht1xm88 88 3 ( ( -LRB- cord-021413-1ht1xm88 88 4 LaBonnardiere LaBonnardiere NNP cord-021413-1ht1xm88 88 5 and and CC cord-021413-1ht1xm88 88 6 deVaurieux deVaurieux NNP cord-021413-1ht1xm88 88 7 , , , cord-021413-1ht1xm88 88 8 1979 1979 CD cord-021413-1ht1xm88 88 9 ) ) -RRB- cord-021413-1ht1xm88 88 10 _SP cord-021413-1ht1xm88 89 1 The the DT cord-021413-1ht1xm88 89 2 use use NN cord-021413-1ht1xm88 89 3 of of IN cord-021413-1ht1xm88 89 4 standard standard JJ cord-021413-1ht1xm88 89 5 methods method NNS cord-021413-1ht1xm88 89 6 to to TO cord-021413-1ht1xm88 89 7 grow grow VB cord-021413-1ht1xm88 89 8 EDIM EDIM NNP cord-021413-1ht1xm88 89 9 virus virus NN cord-021413-1ht1xm88 89 10 in in IN cord-021413-1ht1xm88 89 11 tissue tissue NN cord-021413-1ht1xm88 89 12 culture culture NN cord-021413-1ht1xm88 89 13 has have VBZ cord-021413-1ht1xm88 89 14 resulted result VBN cord-021413-1ht1xm88 89 15 for for IN cord-021413-1ht1xm88 89 16 the the DT cord-021413-1ht1xm88 89 17 most most JJS cord-021413-1ht1xm88 89 18 part part NN cord-021413-1ht1xm88 89 19 in in IN cord-021413-1ht1xm88 89 20 failure failure NN cord-021413-1ht1xm88 89 21 . . . cord-021413-1ht1xm88 90 1 Habermann Habermann NNP cord-021413-1ht1xm88 90 2 ( ( -LRB- cord-021413-1ht1xm88 90 3 1959 1959 CD cord-021413-1ht1xm88 90 4 ) ) -RRB- cord-021413-1ht1xm88 91 1 ( ( -LRB- cord-021413-1ht1xm88 91 2 Thiel Thiel NNP cord-021413-1ht1xm88 91 3 et et NNP cord-021413-1ht1xm88 91 4 al al NNP cord-021413-1ht1xm88 91 5 . . NNP cord-021413-1ht1xm88 91 6 , , , cord-021413-1ht1xm88 91 7 1978 1978 CD cord-021413-1ht1xm88 91 8 ) ) -RRB- cord-021413-1ht1xm88 91 9 . . . cord-021413-1ht1xm88 92 1 Further further RB cord-021413-1ht1xm88 92 2 , , , cord-021413-1ht1xm88 92 3 Babiuk Babiuk NNP cord-021413-1ht1xm88 92 4 et et NNP cord-021413-1ht1xm88 92 5 al al NNP cord-021413-1ht1xm88 92 6 . . . cord-021413-1ht1xm88 93 1 ( ( -LRB- cord-021413-1ht1xm88 93 2 1977 1977 CD cord-021413-1ht1xm88 93 3 ) ) -RRB- cord-021413-1ht1xm88 94 1 and and CC cord-021413-1ht1xm88 94 2 Al Al NNP cord-021413-1ht1xm88 94 3 meida meida NNP cord-021413-1ht1xm88 95 1 et et NNP cord-021413-1ht1xm88 95 2 al al NNP cord-021413-1ht1xm88 95 3 . . . cord-021413-1ht1xm88 96 1 ( ( -LRB- cord-021413-1ht1xm88 96 2 1978 1978 CD cord-021413-1ht1xm88 96 3 ) ) -RRB- cord-021413-1ht1xm88 96 4 state state NN cord-021413-1ht1xm88 96 5 that that WDT cord-021413-1ht1xm88 96 6 calf calf NN cord-021413-1ht1xm88 96 7 rotavirus rotavirus NN cord-021413-1ht1xm88 96 8 production production NN cord-021413-1ht1xm88 96 9 is be VBZ cord-021413-1ht1xm88 96 10 mark mark NNP cord-021413-1ht1xm88 96 11 edly edly RB cord-021413-1ht1xm88 96 12 enhanced enhance VBN cord-021413-1ht1xm88 96 13 when when WRB cord-021413-1ht1xm88 96 14 passaged passage VBN cord-021413-1ht1xm88 96 15 in in IN cord-021413-1ht1xm88 96 16 the the DT cord-021413-1ht1xm88 96 17 presence presence NN cord-021413-1ht1xm88 96 18 of of IN cord-021413-1ht1xm88 96 19 trypsin trypsin NN cord-021413-1ht1xm88 96 20 . . . cord-021413-1ht1xm88 97 1 Clark Clark NNP cord-021413-1ht1xm88 97 2 et et NNP cord-021413-1ht1xm88 97 3 al al NNP cord-021413-1ht1xm88 97 4 . . . cord-021413-1ht1xm88 98 1 ( ( -LRB- cord-021413-1ht1xm88 98 2 1979 1979 CD cord-021413-1ht1xm88 98 3 ) ) -RRB- cord-021413-1ht1xm88 98 4 produced produce VBD cord-021413-1ht1xm88 98 5 high high JJ cord-021413-1ht1xm88 98 6 - - HYPH cord-021413-1ht1xm88 98 7 titer titer NN cord-021413-1ht1xm88 98 8 calf calf NN cord-021413-1ht1xm88 98 9 rotavirus rotavirus NN cord-021413-1ht1xm88 98 10 in in IN cord-021413-1ht1xm88 98 11 a a DT cord-021413-1ht1xm88 98 12 variety variety NN cord-021413-1ht1xm88 98 13 of of IN cord-021413-1ht1xm88 98 14 continuous continuous JJ cord-021413-1ht1xm88 98 15 cell cell NN cord-021413-1ht1xm88 98 16 lines line NNS cord-021413-1ht1xm88 98 17 , , , cord-021413-1ht1xm88 98 18 also also RB cord-021413-1ht1xm88 98 19 by by IN cord-021413-1ht1xm88 98 20 utilizing utilize VBG cord-021413-1ht1xm88 98 21 trypsin trypsin NN cord-021413-1ht1xm88 98 22 , , , cord-021413-1ht1xm88 98 23 and and CC cord-021413-1ht1xm88 98 24 Matsuno Matsuno NNP cord-021413-1ht1xm88 98 25 et et NNP cord-021413-1ht1xm88 98 26 al al NNP cord-021413-1ht1xm88 98 27 . . . cord-021413-1ht1xm88 99 1 ( ( -LRB- cord-021413-1ht1xm88 99 2 1977 1977 CD cord-021413-1ht1xm88 99 3 ) ) -RRB- cord-021413-1ht1xm88 99 4 were be VBD cord-021413-1ht1xm88 99 5 successful successful JJ cord-021413-1ht1xm88 99 6 in in IN cord-021413-1ht1xm88 99 7 producing produce VBG cord-021413-1ht1xm88 99 8 plaques plaque NNS cord-021413-1ht1xm88 99 9 with with IN cord-021413-1ht1xm88 99 10 bovine bovine JJ cord-021413-1ht1xm88 99 11 rotavirus rotavirus NN cord-021413-1ht1xm88 99 12 in in IN cord-021413-1ht1xm88 99 13 monkey monkey NN cord-021413-1ht1xm88 99 14 kidney kidney NN cord-021413-1ht1xm88 99 15 cell cell NN cord-021413-1ht1xm88 99 16 monolayers monolayer NNS cord-021413-1ht1xm88 99 17 when when WRB cord-021413-1ht1xm88 99 18 trypsin trypsin NN cord-021413-1ht1xm88 99 19 was be VBD cord-021413-1ht1xm88 99 20 incorporated incorporate VBN cord-021413-1ht1xm88 99 21 in in IN cord-021413-1ht1xm88 99 22 the the DT cord-021413-1ht1xm88 99 23 overlay overlay NN cord-021413-1ht1xm88 99 24 medium medium NN cord-021413-1ht1xm88 99 25 . . . cord-021413-1ht1xm88 100 1 Estes Estes NNP cord-021413-1ht1xm88 100 2 and and CC cord-021413-1ht1xm88 100 3 Graham Graham NNP cord-021413-1ht1xm88 100 4 ( ( -LRB- cord-021413-1ht1xm88 100 5 1979 1979 CD cord-021413-1ht1xm88 100 6 ) ) -RRB- cord-021413-1ht1xm88 100 7 found find VBD cord-021413-1ht1xm88 100 8 that that IN cord-021413-1ht1xm88 100 9 simian simian JJ cord-021413-1ht1xm88 100 10 virus virus NN cord-021413-1ht1xm88 100 11 titers titer NNS cord-021413-1ht1xm88 100 12 were be VBD cord-021413-1ht1xm88 100 13 enhanced enhance VBN cord-021413-1ht1xm88 100 14 by by IN cord-021413-1ht1xm88 100 15 both both DT cord-021413-1ht1xm88 100 16 trypsin trypsin NN cord-021413-1ht1xm88 100 17 and and CC cord-021413-1ht1xm88 100 18 elastase elastase NN cord-021413-1ht1xm88 100 19 in in IN cord-021413-1ht1xm88 100 20 Vero Vero NNP cord-021413-1ht1xm88 100 21 as as RB cord-021413-1ht1xm88 100 22 well well RB cord-021413-1ht1xm88 100 23 as as IN cord-021413-1ht1xm88 100 24 MA MA NNP cord-021413-1ht1xm88 100 25 104 104 CD cord-021413-1ht1xm88 100 26 cells cell NNS cord-021413-1ht1xm88 100 27 . . . cord-021413-1ht1xm88 101 1 Ramia Ramia NNP cord-021413-1ht1xm88 101 2 and and CC cord-021413-1ht1xm88 101 3 Sattar Sattar NNP cord-021413-1ht1xm88 101 4 ( ( -LRB- cord-021413-1ht1xm88 101 5 1980 1980 CD cord-021413-1ht1xm88 101 6 ) ) -RRB- cord-021413-1ht1xm88 101 7 studied study VBD cord-021413-1ht1xm88 101 8 additional additional JJ cord-021413-1ht1xm88 101 9 proteolytic proteolytic JJ cord-021413-1ht1xm88 101 10 enzymes enzyme NNS cord-021413-1ht1xm88 101 11 utilizing utilize VBG cord-021413-1ht1xm88 101 12 plaque plaque NN cord-021413-1ht1xm88 101 13 formation formation NN cord-021413-1ht1xm88 101 14 by by IN cord-021413-1ht1xm88 101 15 simian simian JJ cord-021413-1ht1xm88 101 16 virus virus NN cord-021413-1ht1xm88 101 17 SA-11 SA-11 NNP cord-021413-1ht1xm88 101 18 in in IN cord-021413-1ht1xm88 101 19 MA MA NNP cord-021413-1ht1xm88 101 20 104 104 CD cord-021413-1ht1xm88 101 21 cells cell NNS cord-021413-1ht1xm88 101 22 as as IN cord-021413-1ht1xm88 101 23 the the DT cord-021413-1ht1xm88 101 24 endpoint endpoint NN cord-021413-1ht1xm88 101 25 . . . cord-021413-1ht1xm88 102 1 Elastase Elastase NNP cord-021413-1ht1xm88 102 2 , , , cord-021413-1ht1xm88 102 3 a a DT cord-021413-1ht1xm88 102 4 - - HYPH cord-021413-1ht1xm88 102 5 chymotrypsin chymotrypsin NN cord-021413-1ht1xm88 102 6 , , , cord-021413-1ht1xm88 102 7 subtilase subtilase NNP cord-021413-1ht1xm88 102 8 , , , cord-021413-1ht1xm88 102 9 pronase pronase NNP cord-021413-1ht1xm88 102 10 , , , cord-021413-1ht1xm88 102 11 and and CC cord-021413-1ht1xm88 102 12 pan pan NNP cord-021413-1ht1xm88 102 13 creatin creatin NNP cord-021413-1ht1xm88 102 14 were be VBD cord-021413-1ht1xm88 102 15 as as RB cord-021413-1ht1xm88 102 16 effective effective JJ cord-021413-1ht1xm88 102 17 as as IN cord-021413-1ht1xm88 102 18 trypsin trypsin NN cord-021413-1ht1xm88 102 19 , , , cord-021413-1ht1xm88 102 20 whereas whereas IN cord-021413-1ht1xm88 102 21 pepsin pepsin NN cord-021413-1ht1xm88 102 22 , , , cord-021413-1ht1xm88 102 23 papain papain NN cord-021413-1ht1xm88 102 24 , , , cord-021413-1ht1xm88 102 25 and and CC cord-021413-1ht1xm88 102 26 thermolysin thermolysin NNP cord-021413-1ht1xm88 102 27 were be VBD cord-021413-1ht1xm88 102 28 ineffective ineffective JJ cord-021413-1ht1xm88 102 29 . . . cord-021413-1ht1xm88 103 1 Another another DT cord-021413-1ht1xm88 103 2 approach approach NN cord-021413-1ht1xm88 103 3 with with IN cord-021413-1ht1xm88 103 4 human human JJ cord-021413-1ht1xm88 103 5 rotavirus rotavirus NN cord-021413-1ht1xm88 103 6 has have VBZ cord-021413-1ht1xm88 103 7 been be VBN cord-021413-1ht1xm88 103 8 to to TO cord-021413-1ht1xm88 103 9 incoφorate incoφorate VB cord-021413-1ht1xm88 103 10 the the DT cord-021413-1ht1xm88 103 11 agent agent NN cord-021413-1ht1xm88 103 12 into into IN cord-021413-1ht1xm88 103 13 cells cell NNS cord-021413-1ht1xm88 103 14 by by IN cord-021413-1ht1xm88 103 15 means mean NNS cord-021413-1ht1xm88 103 16 of of IN cord-021413-1ht1xm88 103 17 low low JJ cord-021413-1ht1xm88 103 18 - - HYPH cord-021413-1ht1xm88 103 19 speed speed NN cord-021413-1ht1xm88 103 20 centrifugation centrifugation NN cord-021413-1ht1xm88 103 21 of of IN cord-021413-1ht1xm88 103 22 the the DT cord-021413-1ht1xm88 103 23 two two CD cord-021413-1ht1xm88 103 24 together together RB cord-021413-1ht1xm88 104 1 ( ( -LRB- cord-021413-1ht1xm88 104 2 Banatvala Banatvala NNP cord-021413-1ht1xm88 104 3 et et NNP cord-021413-1ht1xm88 104 4 al al NNP cord-021413-1ht1xm88 104 5 . . NNP cord-021413-1ht1xm88 104 6 , , , cord-021413-1ht1xm88 104 7 1975 1975 CD cord-021413-1ht1xm88 104 8 ; ; : cord-021413-1ht1xm88 104 9 Bryden Bryden NNP cord-021413-1ht1xm88 104 10 et et NNP cord-021413-1ht1xm88 104 11 al al NNP cord-021413-1ht1xm88 104 12 . . NNP cord-021413-1ht1xm88 104 13 , , , cord-021413-1ht1xm88 104 14 1977 1977 CD cord-021413-1ht1xm88 105 1 ; ; : cord-021413-1ht1xm88 105 2 Schoub Schoub NNP cord-021413-1ht1xm88 105 3 et et FW cord-021413-1ht1xm88 105 4 al al NNP cord-021413-1ht1xm88 105 5 . . . cord-021413-1ht1xm88 106 1 , , , cord-021413-1ht1xm88 106 2 1979 1979 CD cord-021413-1ht1xm88 106 3 ; ; : cord-021413-1ht1xm88 106 4 Wyatt Wyatt NNP cord-021413-1ht1xm88 106 5 et et NNP cord-021413-1ht1xm88 106 6 al al NNP cord-021413-1ht1xm88 106 7 . . NNP cord-021413-1ht1xm88 106 8 , , , cord-021413-1ht1xm88 106 9 1980 1980 CD cord-021413-1ht1xm88 106 10 ) ) -RRB- cord-021413-1ht1xm88 106 11 . . . cord-021413-1ht1xm88 107 1 It -PRON- PRP cord-021413-1ht1xm88 107 2 remains remain VBZ cord-021413-1ht1xm88 107 3 to to TO cord-021413-1ht1xm88 107 4 be be VB cord-021413-1ht1xm88 107 5 seen see VBN cord-021413-1ht1xm88 107 6 if if IN cord-021413-1ht1xm88 107 7 similar similar JJ cord-021413-1ht1xm88 107 8 treatments treatment NNS cord-021413-1ht1xm88 107 9 will will MD cord-021413-1ht1xm88 107 10 lead lead VB cord-021413-1ht1xm88 107 11 to to IN cord-021413-1ht1xm88 107 12 suc suc NNP cord-021413-1ht1xm88 107 13 cessful cessful NN cord-021413-1ht1xm88 107 14 cultivation cultivation NN cord-021413-1ht1xm88 107 15 of of IN cord-021413-1ht1xm88 107 16 EDIM EDIM NNP cord-021413-1ht1xm88 107 17 virus virus NN cord-021413-1ht1xm88 107 18 in in IN cord-021413-1ht1xm88 107 19 tissue tissue NN cord-021413-1ht1xm88 107 20 culture culture NN cord-021413-1ht1xm88 107 21 . . . cord-021413-1ht1xm88 108 1 Chick chick NN cord-021413-1ht1xm88 108 2 embryos embryo NNS cord-021413-1ht1xm88 108 3 appeared appear VBD cord-021413-1ht1xm88 108 4 unaffected unaffected JJ cord-021413-1ht1xm88 108 5 when when WRB cord-021413-1ht1xm88 108 6 the the DT cord-021413-1ht1xm88 108 7 chorioallantois chorioallantois NN cord-021413-1ht1xm88 108 8 was be VBD cord-021413-1ht1xm88 108 9 inoculated inoculate VBN cord-021413-1ht1xm88 108 10 . . . cord-021413-1ht1xm88 109 1 The the DT cord-021413-1ht1xm88 109 2 agent agent NN cord-021413-1ht1xm88 109 3 did do VBD cord-021413-1ht1xm88 109 4 survive survive VB cord-021413-1ht1xm88 109 5 up up IN cord-021413-1ht1xm88 109 6 to to TO cord-021413-1ht1xm88 109 7 5 5 CD cord-021413-1ht1xm88 109 8 days day NNS cord-021413-1ht1xm88 109 9 , , , cord-021413-1ht1xm88 109 10 but but CC cord-021413-1ht1xm88 109 11 an an DT cord-021413-1ht1xm88 109 12 increase increase NN cord-021413-1ht1xm88 109 13 in in IN cord-021413-1ht1xm88 109 14 infectious infectious JJ cord-021413-1ht1xm88 109 15 titer titer NN cord-021413-1ht1xm88 109 16 could could MD cord-021413-1ht1xm88 109 17 not not RB cord-021413-1ht1xm88 109 18 be be VB cord-021413-1ht1xm88 109 19 demonstrated demonstrate VBN cord-021413-1ht1xm88 109 20 ( ( -LRB- cord-021413-1ht1xm88 109 21 Kraft Kraft NNP cord-021413-1ht1xm88 109 22 , , , cord-021413-1ht1xm88 109 23 1958 1958 CD cord-021413-1ht1xm88 109 24 ) ) -RRB- cord-021413-1ht1xm88 109 25 . . . cord-021413-1ht1xm88 110 1 Moon Moon NNP cord-021413-1ht1xm88 110 2 ( ( -LRB- cord-021413-1ht1xm88 110 3 1978 1978 CD cord-021413-1ht1xm88 110 4 ) ) -RRB- cord-021413-1ht1xm88 110 5 of of IN cord-021413-1ht1xm88 110 6 each each DT cord-021413-1ht1xm88 110 7 disease disease NN cord-021413-1ht1xm88 110 8 appears appear VBZ cord-021413-1ht1xm88 110 9 to to TO cord-021413-1ht1xm88 110 10 be be VB cord-021413-1ht1xm88 110 11 reflected reflect VBN cord-021413-1ht1xm88 110 12 not not RB cord-021413-1ht1xm88 110 13 only only RB cord-021413-1ht1xm88 110 14 in in IN cord-021413-1ht1xm88 110 15 the the DT cord-021413-1ht1xm88 110 16 particular particular JJ cord-021413-1ht1xm88 110 17 group group NN cord-021413-1ht1xm88 110 18 of of IN cord-021413-1ht1xm88 110 19 cells cell NNS cord-021413-1ht1xm88 110 20 but but CC cord-021413-1ht1xm88 110 21 also also RB cord-021413-1ht1xm88 110 22 in in IN cord-021413-1ht1xm88 110 23 the the DT cord-021413-1ht1xm88 110 24 numbers number NNS cord-021413-1ht1xm88 110 25 of of IN cord-021413-1ht1xm88 110 26 host host NN cord-021413-1ht1xm88 110 27 cells cell NNS cord-021413-1ht1xm88 110 28 involved involve VBN cord-021413-1ht1xm88 110 29 . . . cord-021413-1ht1xm88 111 1 Lucid lucid JJ cord-021413-1ht1xm88 111 2 descriptions description NNS cord-021413-1ht1xm88 111 3 of of IN cord-021413-1ht1xm88 111 4 the the DT cord-021413-1ht1xm88 111 5 natural natural JJ cord-021413-1ht1xm88 111 6 clinical clinical JJ cord-021413-1ht1xm88 111 7 disease disease NN cord-021413-1ht1xm88 111 8 are be VBP cord-021413-1ht1xm88 111 9 given give VBN cord-021413-1ht1xm88 111 10 by by IN cord-021413-1ht1xm88 111 11 Cheever Cheever NNP cord-021413-1ht1xm88 111 12 and and CC cord-021413-1ht1xm88 111 13 Mueller(1947 Mueller(1947 NNP cord-021413-1ht1xm88 111 14 ) ) -RRB- cord-021413-1ht1xm88 111 15 , , , cord-021413-1ht1xm88 111 16 Seamer Seamer NNP cord-021413-1ht1xm88 111 17 ( ( -LRB- cord-021413-1ht1xm88 111 18 1967 1967 CD cord-021413-1ht1xm88 111 19 ) ) -RRB- cord-021413-1ht1xm88 111 20 , , , cord-021413-1ht1xm88 111 21 and and CC cord-021413-1ht1xm88 111 22 McClure McClure NNP cord-021413-1ht1xm88 111 23 et et NNP cord-021413-1ht1xm88 111 24 al al NNP cord-021413-1ht1xm88 111 25 . . . cord-021413-1ht1xm88 112 1 ( ( -LRB- cord-021413-1ht1xm88 112 2 1978 1978 CD cord-021413-1ht1xm88 112 3 ) ) -RRB- cord-021413-1ht1xm88 112 4 . . . cord-021413-1ht1xm88 113 1 The the DT cord-021413-1ht1xm88 113 2 experimental experimental JJ cord-021413-1ht1xm88 113 3 disease disease NN cord-021413-1ht1xm88 113 4 does do VBZ cord-021413-1ht1xm88 113 5 not not RB cord-021413-1ht1xm88 113 6 differ differ VB cord-021413-1ht1xm88 113 7 signifi signifi NNP cord-021413-1ht1xm88 113 8 cantly cantly RB cord-021413-1ht1xm88 114 1 ( ( -LRB- cord-021413-1ht1xm88 114 2 Kraft Kraft NNP cord-021413-1ht1xm88 114 3 , , , cord-021413-1ht1xm88 114 4 1957 1957 CD cord-021413-1ht1xm88 114 5 ( ( -LRB- cord-021413-1ht1xm88 114 6 Kraft Kraft NNP cord-021413-1ht1xm88 114 7 , , , cord-021413-1ht1xm88 114 8 , , , cord-021413-1ht1xm88 114 9 1962b 1962b CD cord-021413-1ht1xm88 114 10 . . . cord-021413-1ht1xm88 115 1 Overt overt JJ cord-021413-1ht1xm88 115 2 illness illness NN cord-021413-1ht1xm88 115 3 is be VBZ cord-021413-1ht1xm88 115 4 confined confine VBN cord-021413-1ht1xm88 115 5 to to IN cord-021413-1ht1xm88 115 6 pre- pre- JJ cord-021413-1ht1xm88 115 7 Typical typical JJ cord-021413-1ht1xm88 115 8 appearance appearance NN cord-021413-1ht1xm88 115 9 of of IN cord-021413-1ht1xm88 115 10 infant infant NN cord-021413-1ht1xm88 115 11 mice mouse NNS cord-021413-1ht1xm88 115 12 infected infect VBN cord-021413-1ht1xm88 115 13 with with IN cord-021413-1ht1xm88 115 14 enterotropic enterotropic NNP cord-021413-1ht1xm88 115 15 MHV MHV NNP cord-021413-1ht1xm88 115 16 ( ( -LRB- cord-021413-1ht1xm88 115 17 pair pair NN cord-021413-1ht1xm88 115 18 of of IN cord-021413-1ht1xm88 115 19 mice mouse NNS cord-021413-1ht1xm88 115 20 at at IN cord-021413-1ht1xm88 115 21 left left NN cord-021413-1ht1xm88 115 22 ) ) -RRB- cord-021413-1ht1xm88 115 23 or or CC cord-021413-1ht1xm88 115 24 rotavirus rotavirus JJ cord-021413-1ht1xm88 115 25 ( ( -LRB- cord-021413-1ht1xm88 115 26 pair pair NN cord-021413-1ht1xm88 115 27 at at IN cord-021413-1ht1xm88 115 28 right right NN cord-021413-1ht1xm88 115 29 ) ) -RRB- cord-021413-1ht1xm88 115 30 compared compare VBN cord-021413-1ht1xm88 115 31 with with IN cord-021413-1ht1xm88 115 32 normal normal JJ cord-021413-1ht1xm88 115 33 mice mouse NNS cord-021413-1ht1xm88 115 34 of of IN cord-021413-1ht1xm88 115 35 the the DT cord-021413-1ht1xm88 115 36 same same JJ cord-021413-1ht1xm88 115 37 age age NN cord-021413-1ht1xm88 115 38 ( ( -LRB- cord-021413-1ht1xm88 115 39 center center NN cord-021413-1ht1xm88 115 40 pair pair NN cord-021413-1ht1xm88 115 41 ) ) -RRB- cord-021413-1ht1xm88 115 42 . . . cord-021413-1ht1xm88 116 1 Note note VB cord-021413-1ht1xm88 116 2 the the DT cord-021413-1ht1xm88 116 3 evidence evidence NN cord-021413-1ht1xm88 116 4 of of IN cord-021413-1ht1xm88 116 5 inanition inanition NN cord-021413-1ht1xm88 116 6 and and CC cord-021413-1ht1xm88 116 7 dehydration dehydration NN cord-021413-1ht1xm88 116 8 in in IN cord-021413-1ht1xm88 116 9 the the DT cord-021413-1ht1xm88 116 10 MHV MHV NNP cord-021413-1ht1xm88 116 11 - - HYPH cord-021413-1ht1xm88 116 12 infected infect VBN cord-021413-1ht1xm88 116 13 animals animal NNS cord-021413-1ht1xm88 116 14 , , , cord-021413-1ht1xm88 116 15 whereas whereas IN cord-021413-1ht1xm88 116 16 those those DT cord-021413-1ht1xm88 116 17 infected infect VBN cord-021413-1ht1xm88 116 18 with with IN cord-021413-1ht1xm88 116 19 rotavirus rotavirus JJ cord-021413-1ht1xm88 116 20 show show NN cord-021413-1ht1xm88 116 21 mainly mainly RB cord-021413-1ht1xm88 116 22 a a DT cord-021413-1ht1xm88 116 23 somewhat somewhat RB cord-021413-1ht1xm88 116 24 prominent prominent JJ cord-021413-1ht1xm88 116 25 abdomen abdoman NNS cord-021413-1ht1xm88 116 26 and and CC cord-021413-1ht1xm88 116 27 only only RB cord-021413-1ht1xm88 116 28 a a DT cord-021413-1ht1xm88 116 29 slightly slightly RB cord-021413-1ht1xm88 116 30 smaller small JJR cord-021413-1ht1xm88 116 31 size size NN cord-021413-1ht1xm88 116 32 than than IN cord-021413-1ht1xm88 116 33 the the DT cord-021413-1ht1xm88 116 34 normal normal JJ cord-021413-1ht1xm88 116 35 control control NN cord-021413-1ht1xm88 116 36 mice mouse NNS cord-021413-1ht1xm88 116 37 . . . cord-021413-1ht1xm88 117 1 weanling weanle VBG cord-021413-1ht1xm88 117 2 mice mouse NNS cord-021413-1ht1xm88 117 3 . . . cord-021413-1ht1xm88 118 1 T T NNP cord-021413-1ht1xm88 118 2 h h NN cord-021413-1ht1xm88 118 3 e e NN cord-021413-1ht1xm88 119 1 first first JJ cord-021413-1ht1xm88 119 2 signs sign NNS cord-021413-1ht1xm88 119 3 usually usually RB cord-021413-1ht1xm88 119 4 appear appear VBP cord-021413-1ht1xm88 119 5 at at IN cord-021413-1ht1xm88 119 6 7 7 CD cord-021413-1ht1xm88 119 7 -8 -8 JJ cord-021413-1ht1xm88 119 8 days day NNS cord-021413-1ht1xm88 119 9 of of IN cord-021413-1ht1xm88 119 10 age age NN cord-021413-1ht1xm88 119 11 . . . cord-021413-1ht1xm88 120 1 In in IN cord-021413-1ht1xm88 120 2 mild mild JJ cord-021413-1ht1xm88 120 3 cases case NNS cord-021413-1ht1xm88 120 4 diarrhea diarrhea NN cord-021413-1ht1xm88 120 5 is be VBZ cord-021413-1ht1xm88 120 6 manifested manifest VBN cord-021413-1ht1xm88 120 7 by by IN cord-021413-1ht1xm88 120 8 a a DT cord-021413-1ht1xm88 120 9 minimal minimal JJ cord-021413-1ht1xm88 120 10 amount amount NN cord-021413-1ht1xm88 120 11 of of IN cord-021413-1ht1xm88 120 12 pasty pasty JJ cord-021413-1ht1xm88 120 13 fecal fecal JJ cord-021413-1ht1xm88 120 14 material material NN cord-021413-1ht1xm88 120 15 about about IN cord-021413-1ht1xm88 120 16 the the DT cord-021413-1ht1xm88 120 17 perineum perineum NN cord-021413-1ht1xm88 120 18 . . . cord-021413-1ht1xm88 121 1 In in IN cord-021413-1ht1xm88 121 2 severe severe JJ cord-021413-1ht1xm88 121 3 cases case NNS cord-021413-1ht1xm88 121 4 the the DT cord-021413-1ht1xm88 121 5 amount amount NN cord-021413-1ht1xm88 121 6 is be VBZ cord-021413-1ht1xm88 121 7 copious copious JJ cord-021413-1ht1xm88 121 8 , , , cord-021413-1ht1xm88 121 9 the the DT cord-021413-1ht1xm88 121 10 entire entire JJ cord-021413-1ht1xm88 121 11 infant infant NN cord-021413-1ht1xm88 121 12 becoming become VBG cord-021413-1ht1xm88 121 13 soiled soil VBN cord-021413-1ht1xm88 121 14 . . . cord-021413-1ht1xm88 122 1 Rectal rectal JJ cord-021413-1ht1xm88 122 2 impaction impaction NN cord-021413-1ht1xm88 122 3 may may MD cord-021413-1ht1xm88 122 4 occur occur VB cord-021413-1ht1xm88 122 5 at at IN cord-021413-1ht1xm88 122 6 about about RB cord-021413-1ht1xm88 122 7 1 1 CD cord-021413-1ht1xm88 122 8 2 2 CD cord-021413-1ht1xm88 122 9 -1 -1 NN cord-021413-1ht1xm88 122 10 6 6 CD cord-021413-1ht1xm88 122 11 days day NNS cord-021413-1ht1xm88 122 12 of of IN cord-021413-1ht1xm88 122 13 a a DT cord-021413-1ht1xm88 122 14 g g NN cord-021413-1ht1xm88 122 15 e e NN cord-021413-1ht1xm88 122 16 , , , cord-021413-1ht1xm88 122 17 and and CC cord-021413-1ht1xm88 122 18 death death NN cord-021413-1ht1xm88 122 19 can can MD cord-021413-1ht1xm88 122 20 ensue ensue VB cord-021413-1ht1xm88 122 21 if if IN cord-021413-1ht1xm88 122 22 the the DT cord-021413-1ht1xm88 122 23 impacted impact VBN cord-021413-1ht1xm88 122 24 mass mass NN cord-021413-1ht1xm88 122 25 is be VBZ cord-021413-1ht1xm88 122 26 not not RB cord-021413-1ht1xm88 122 27 removed remove VBN cord-021413-1ht1xm88 122 28 spontaneously spontaneously RB cord-021413-1ht1xm88 122 29 or or CC cord-021413-1ht1xm88 122 30 deliberately deliberately RB cord-021413-1ht1xm88 122 31 . . . cord-021413-1ht1xm88 123 1 Death death NN cord-021413-1ht1xm88 123 2 does do VBZ cord-021413-1ht1xm88 123 3 not not RB cord-021413-1ht1xm88 123 4 seem seem VB cord-021413-1ht1xm88 123 5 to to TO cord-021413-1ht1xm88 123 6 be be VB cord-021413-1ht1xm88 123 7 the the DT cord-021413-1ht1xm88 123 8 result result NN cord-021413-1ht1xm88 123 9 of of IN cord-021413-1ht1xm88 123 10 the the DT cord-021413-1ht1xm88 123 11 virus virus NN cord-021413-1ht1xm88 123 12 infection infection NN cord-021413-1ht1xm88 123 13 per per FW cord-021413-1ht1xm88 123 14 se se FW cord-021413-1ht1xm88 123 15 , , , cord-021413-1ht1xm88 123 16 but but CC cord-021413-1ht1xm88 123 17 rather rather RB cord-021413-1ht1xm88 123 18 as as IN cord-021413-1ht1xm88 123 19 a a DT cord-021413-1ht1xm88 123 20 consequence consequence NN cord-021413-1ht1xm88 123 21 of of IN cord-021413-1ht1xm88 123 22 protracted protracted JJ cord-021413-1ht1xm88 123 23 obstipation obstipation NN cord-021413-1ht1xm88 123 24 . . . cord-021413-1ht1xm88 124 1 In in IN cord-021413-1ht1xm88 124 2 pure pure JJ cord-021413-1ht1xm88 124 3 E e NN cord-021413-1ht1xm88 124 4 D d NN cord-021413-1ht1xm88 124 5 I i NN cord-021413-1ht1xm88 124 6 M M NNP cord-021413-1ht1xm88 124 7 virus virus NN cord-021413-1ht1xm88 124 8 infections infection NNS cord-021413-1ht1xm88 124 9 , , , cord-021413-1ht1xm88 124 10 mice mouse NNS cord-021413-1ht1xm88 124 11 continue continue VBP cord-021413-1ht1xm88 124 12 to to TO cord-021413-1ht1xm88 124 13 nurse nurse VB cord-021413-1ht1xm88 124 14 throughout throughout IN cord-021413-1ht1xm88 124 15 their -PRON- PRP$ cord-021413-1ht1xm88 124 16 illness illness NN cord-021413-1ht1xm88 124 17 ( ( -LRB- cord-021413-1ht1xm88 124 18 in in IN cord-021413-1ht1xm88 124 19 the the DT cord-021413-1ht1xm88 124 20 absence absence NN cord-021413-1ht1xm88 124 21 of of IN cord-021413-1ht1xm88 124 22 impaction impaction NN cord-021413-1ht1xm88 124 23 ) ) -RRB- cord-021413-1ht1xm88 124 24 . . . cord-021413-1ht1xm88 125 1 They -PRON- PRP cord-021413-1ht1xm88 125 2 may may MD cord-021413-1ht1xm88 125 3 be be VB cord-021413-1ht1xm88 125 4 slightly slightly RB cord-021413-1ht1xm88 125 5 stunted stunted JJ cord-021413-1ht1xm88 125 6 ( ( -LRB- cord-021413-1ht1xm88 125 7 Fig fig NN cord-021413-1ht1xm88 125 8 . . NNP cord-021413-1ht1xm88 125 9 2 2 CD cord-021413-1ht1xm88 125 10 ) ) -RRB- cord-021413-1ht1xm88 125 11 , , , cord-021413-1ht1xm88 125 12 but but CC cord-021413-1ht1xm88 125 13 those those DT cord-021413-1ht1xm88 125 14 with with IN cord-021413-1ht1xm88 125 15 mild mild JJ cord-021413-1ht1xm88 125 16 cases case NNS cord-021413-1ht1xm88 125 17 soon soon RB cord-021413-1ht1xm88 125 18 attain attain VBP cord-021413-1ht1xm88 125 19 the the DT cord-021413-1ht1xm88 125 20 weight weight NN cord-021413-1ht1xm88 125 21 of of IN cord-021413-1ht1xm88 125 22 their -PRON- PRP$ cord-021413-1ht1xm88 125 23 nondiarrheal nondiarrheal NN cord-021413-1ht1xm88 125 24 peers peer NNS cord-021413-1ht1xm88 125 25 . . . cord-021413-1ht1xm88 126 1 Especially especially RB cord-021413-1ht1xm88 126 2 when when WRB cord-021413-1ht1xm88 126 3 diarrhea diarrhea NN cord-021413-1ht1xm88 126 4 is be VBZ cord-021413-1ht1xm88 126 5 mild mild JJ cord-021413-1ht1xm88 126 6 , , , cord-021413-1ht1xm88 126 7 morbidity morbidity NN cord-021413-1ht1xm88 126 8 in in IN cord-021413-1ht1xm88 126 9 the the DT cord-021413-1ht1xm88 126 10 natural natural JJ cord-021413-1ht1xm88 126 11 disease disease NN cord-021413-1ht1xm88 126 12 m m NNP cord-021413-1ht1xm88 126 13 a a DT cord-021413-1ht1xm88 126 14 y y NN cord-021413-1ht1xm88 126 15 be be VB cord-021413-1ht1xm88 126 16 difficult difficult JJ cord-021413-1ht1xm88 126 17 to to TO cord-021413-1ht1xm88 126 18 ascertain ascertain VB cord-021413-1ht1xm88 126 19 , , , cord-021413-1ht1xm88 126 20 but but CC cord-021413-1ht1xm88 126 21 one one PRP cord-021413-1ht1xm88 126 22 could could MD cord-021413-1ht1xm88 126 23 quite quite RB cord-021413-1ht1xm88 126 24 cor cor NNP cord-021413-1ht1xm88 126 25 rectly rectly RB cord-021413-1ht1xm88 126 26 assume assume VB cord-021413-1ht1xm88 126 27 that that IN cord-021413-1ht1xm88 126 28 , , , cord-021413-1ht1xm88 126 29 if if IN cord-021413-1ht1xm88 126 30 diarrheal diarrheal JJ cord-021413-1ht1xm88 126 31 signs sign NNS cord-021413-1ht1xm88 126 32 are be VBP cord-021413-1ht1xm88 126 33 observed observe VBN cord-021413-1ht1xm88 126 34 in in IN cord-021413-1ht1xm88 126 35 a a DT cord-021413-1ht1xm88 126 36 few few JJ cord-021413-1ht1xm88 126 37 litters litter NNS cord-021413-1ht1xm88 126 38 , , , cord-021413-1ht1xm88 126 39 it -PRON- PRP cord-021413-1ht1xm88 126 40 is be VBZ cord-021413-1ht1xm88 126 41 likely likely JJ cord-021413-1ht1xm88 126 42 that that IN cord-021413-1ht1xm88 126 43 all all DT cord-021413-1ht1xm88 126 44 infants infant NNS cord-021413-1ht1xm88 126 45 in in IN cord-021413-1ht1xm88 126 46 a a DT cord-021413-1ht1xm88 126 47 colony colony NN cord-021413-1ht1xm88 126 48 will will MD cord-021413-1ht1xm88 126 49 sooner sooner RB cord-021413-1ht1xm88 126 50 or or CC cord-021413-1ht1xm88 126 51 later later RB cord-021413-1ht1xm88 126 52 be be VB cord-021413-1ht1xm88 126 53 affected affect VBN cord-021413-1ht1xm88 126 54 . . . cord-021413-1ht1xm88 127 1 Concerning concern VBG cord-021413-1ht1xm88 127 2 mortality mortality NN cord-021413-1ht1xm88 127 3 , , , cord-021413-1ht1xm88 127 4 Cheever Cheever NNP cord-021413-1ht1xm88 127 5 and and CC cord-021413-1ht1xm88 127 6 Mueller Mueller NNP cord-021413-1ht1xm88 127 7 ( ( -LRB- cord-021413-1ht1xm88 127 8 1947 1947 CD cord-021413-1ht1xm88 127 9 ) ) -RRB- cord-021413-1ht1xm88 127 10 state state NN cord-021413-1ht1xm88 127 11 that that IN cord-021413-1ht1xm88 127 12 there there EX cord-021413-1ht1xm88 127 13 was be VBD cord-021413-1ht1xm88 127 14 both both DT cord-021413-1ht1xm88 127 15 100 100 CD cord-021413-1ht1xm88 127 16 % % NN cord-021413-1ht1xm88 127 17 recovery recovery NN cord-021413-1ht1xm88 127 18 and and CC cord-021413-1ht1xm88 127 19 100 100 CD cord-021413-1ht1xm88 127 20 % % NN cord-021413-1ht1xm88 127 21 lethality lethality NN cord-021413-1ht1xm88 127 22 in in IN cord-021413-1ht1xm88 127 23 their -PRON- PRP$ cord-021413-1ht1xm88 127 24 outbreaks outbreak NNS cord-021413-1ht1xm88 127 25 . . . cord-021413-1ht1xm88 128 1 Based base VBN cord-021413-1ht1xm88 128 2 on on IN cord-021413-1ht1xm88 128 3 present present JJ cord-021413-1ht1xm88 128 4 k k NNP cord-021413-1ht1xm88 128 5 n n NNP cord-021413-1ht1xm88 128 6 o o NNP cord-021413-1ht1xm88 128 7 w w NN cord-021413-1ht1xm88 128 8 l l NN cord-021413-1ht1xm88 128 9 e e NN cord-021413-1ht1xm88 128 10 d d NN cord-021413-1ht1xm88 128 11 g g NN cord-021413-1ht1xm88 128 12 e e NN cord-021413-1ht1xm88 128 13 , , , cord-021413-1ht1xm88 128 14 the the DT cord-021413-1ht1xm88 128 15 first first JJ cord-021413-1ht1xm88 128 16 is be VBZ cord-021413-1ht1xm88 128 17 suggestive suggestive JJ cord-021413-1ht1xm88 128 18 of of IN cord-021413-1ht1xm88 128 19 E e NN cord-021413-1ht1xm88 128 20 D d NN cord-021413-1ht1xm88 128 21 I i NN cord-021413-1ht1xm88 128 22 M m CD cord-021413-1ht1xm88 128 23 virus virus NN cord-021413-1ht1xm88 128 24 infection infection NN cord-021413-1ht1xm88 128 25 and and CC cord-021413-1ht1xm88 128 26 the the DT cord-021413-1ht1xm88 128 27 latter latter JJ cord-021413-1ht1xm88 128 28 of of IN cord-021413-1ht1xm88 128 29 another another DT cord-021413-1ht1xm88 128 30 disease disease NN cord-021413-1ht1xm88 128 31 , , , cord-021413-1ht1xm88 128 32 perhaps perhaps RB cord-021413-1ht1xm88 128 33 murine murine JJ cord-021413-1ht1xm88 128 34 ( ( -LRB- cord-021413-1ht1xm88 128 35 mouse mouse NN cord-021413-1ht1xm88 128 36 ) ) -RRB- cord-021413-1ht1xm88 128 37 hepatitis hepatitis NN cord-021413-1ht1xm88 128 38 . . . cord-021413-1ht1xm88 129 1 At at IN cord-021413-1ht1xm88 129 2 no no DT cord-021413-1ht1xm88 129 3 time time NN cord-021413-1ht1xm88 129 4 do do VB cord-021413-1ht1xm88 129 5 a a DT cord-021413-1ht1xm88 129 6 d d NN cord-021413-1ht1xm88 129 7 u u NN cord-021413-1ht1xm88 129 8 h h NN cord-021413-1ht1xm88 130 1 mice mouse NNS cord-021413-1ht1xm88 130 2 exhibit exhibit VBP cord-021413-1ht1xm88 130 3 signs sign NNS cord-021413-1ht1xm88 130 4 of of IN cord-021413-1ht1xm88 130 5 illness illness NN cord-021413-1ht1xm88 130 6 ascribable ascribable JJ cord-021413-1ht1xm88 130 7 to to IN cord-021413-1ht1xm88 130 8 E e NN cord-021413-1ht1xm88 130 9 D d NN cord-021413-1ht1xm88 130 10 I i NN cord-021413-1ht1xm88 130 11 M m CD cord-021413-1ht1xm88 130 12 virus virus NN cord-021413-1ht1xm88 130 13 infection infection NN cord-021413-1ht1xm88 130 14 . . . cord-021413-1ht1xm88 131 1 In in IN cord-021413-1ht1xm88 131 2 the the DT cord-021413-1ht1xm88 131 3 experimentally experimentally RB cord-021413-1ht1xm88 131 4 induced induce VBN cord-021413-1ht1xm88 131 5 dis dis NN cord-021413-1ht1xm88 131 6 ease ease NN cord-021413-1ht1xm88 131 7 , , , cord-021413-1ht1xm88 131 8 the the DT cord-021413-1ht1xm88 131 9 absence absence NN cord-021413-1ht1xm88 131 10 of of IN cord-021413-1ht1xm88 131 11 external external JJ cord-021413-1ht1xm88 131 12 clinical clinical JJ cord-021413-1ht1xm88 131 13 signs sign NNS cord-021413-1ht1xm88 131 14 can can MD cord-021413-1ht1xm88 131 15 not not RB cord-021413-1ht1xm88 131 16 be be VB cord-021413-1ht1xm88 131 17 relied rely VBN cord-021413-1ht1xm88 131 18 upon upon IN cord-021413-1ht1xm88 131 19 for for IN cord-021413-1ht1xm88 131 20 a a DT cord-021413-1ht1xm88 131 21 negative negative JJ cord-021413-1ht1xm88 131 22 diagnosis diagnosis NN cord-021413-1ht1xm88 131 23 ( ( -LRB- cord-021413-1ht1xm88 131 24 Kraft Kraft NNP cord-021413-1ht1xm88 131 25 , , , cord-021413-1ht1xm88 131 26 1957 1957 CD cord-021413-1ht1xm88 131 27 ) ) -RRB- cord-021413-1ht1xm88 131 28 . . . cord-021413-1ht1xm88 132 1 Necropsy necropsy JJ cord-021413-1ht1xm88 132 2 of of IN cord-021413-1ht1xm88 132 3 each each DT cord-021413-1ht1xm88 132 4 animal animal NN cord-021413-1ht1xm88 132 5 is be VBZ cord-021413-1ht1xm88 132 6 essential essential JJ cord-021413-1ht1xm88 132 7 . . . cord-021413-1ht1xm88 133 1 In in IN cord-021413-1ht1xm88 133 2 this this DT cord-021413-1ht1xm88 133 3 w w NN cord-021413-1ht1xm88 133 4 a a DT cord-021413-1ht1xm88 133 5 y y NN cord-021413-1ht1xm88 133 6 , , , cord-021413-1ht1xm88 133 7 the the DT cord-021413-1ht1xm88 133 8 appearance appearance NN cord-021413-1ht1xm88 133 9 of of IN cord-021413-1ht1xm88 133 10 the the DT cord-021413-1ht1xm88 133 11 colonic colonic JJ cord-021413-1ht1xm88 133 12 contents content NNS cord-021413-1ht1xm88 133 13 can can MD cord-021413-1ht1xm88 133 14 be be VB cord-021413-1ht1xm88 133 15 observed observe VBN cord-021413-1ht1xm88 133 16 , , , cord-021413-1ht1xm88 133 17 which which WDT cord-021413-1ht1xm88 133 18 in in IN cord-021413-1ht1xm88 133 19 normal normal JJ cord-021413-1ht1xm88 133 20 infant infant NN cord-021413-1ht1xm88 133 21 mice mouse NNS cord-021413-1ht1xm88 133 22 are be VBP cord-021413-1ht1xm88 133 23 burnt burn VBN cord-021413-1ht1xm88 133 24 orange orange NN cord-021413-1ht1xm88 133 25 in in IN cord-021413-1ht1xm88 133 26 color color NN cord-021413-1ht1xm88 133 27 and and CC cord-021413-1ht1xm88 133 28 semisolid semisolid JJ cord-021413-1ht1xm88 133 29 but but CC cord-021413-1ht1xm88 133 30 formed form VBN cord-021413-1ht1xm88 133 31 in in IN cord-021413-1ht1xm88 133 32 consistency consistency NN cord-021413-1ht1xm88 133 33 . . . cord-021413-1ht1xm88 134 1 T T NNP cord-021413-1ht1xm88 134 2 h h NN cord-021413-1ht1xm88 134 3 e e NN cord-021413-1ht1xm88 134 4 colon colon NN cord-021413-1ht1xm88 134 5 is be VBZ cord-021413-1ht1xm88 134 6 not not RB cord-021413-1ht1xm88 134 7 distended distended JJ cord-021413-1ht1xm88 134 8 . . . cord-021413-1ht1xm88 135 1 In in IN cord-021413-1ht1xm88 135 2 diarrheal diarrheal JJ cord-021413-1ht1xm88 135 3 m m NNP cord-021413-1ht1xm88 135 4 i i NN cord-021413-1ht1xm88 135 5 c c NN cord-021413-1ht1xm88 135 6 e e NNP cord-021413-1ht1xm88 135 7 , , , cord-021413-1ht1xm88 135 8 however however RB cord-021413-1ht1xm88 135 9 , , , cord-021413-1ht1xm88 135 10 even even RB cord-021413-1ht1xm88 135 11 in in IN cord-021413-1ht1xm88 135 12 those those DT cord-021413-1ht1xm88 135 13 with with IN cord-021413-1ht1xm88 135 14 no no DT cord-021413-1ht1xm88 135 15 external external JJ cord-021413-1ht1xm88 135 16 soiling soiling NN cord-021413-1ht1xm88 135 17 , , , cord-021413-1ht1xm88 135 18 the the DT cord-021413-1ht1xm88 135 19 colonic colonic JJ cord-021413-1ht1xm88 135 20 contents content NNS cord-021413-1ht1xm88 135 21 are be VBP cord-021413-1ht1xm88 135 22 fluid fluid JJ cord-021413-1ht1xm88 135 23 or or CC cord-021413-1ht1xm88 135 24 m m NN cord-021413-1ht1xm88 136 1 u u NNP cord-021413-1ht1xm88 136 2 c c NNP cord-021413-1ht1xm88 137 1 o o UH cord-021413-1ht1xm88 138 1 i i NNP cord-021413-1ht1xm88 138 2 d d NNP cord-021413-1ht1xm88 138 3 , , , cord-021413-1ht1xm88 138 4 bright bright JJ cord-021413-1ht1xm88 138 5 lemon lemon NN cord-021413-1ht1xm88 138 6 yellow yellow JJ cord-021413-1ht1xm88 138 7 to to IN cord-021413-1ht1xm88 138 8 amber amber NN cord-021413-1ht1xm88 138 9 , , , cord-021413-1ht1xm88 138 10 or or CC cord-021413-1ht1xm88 138 11 gray gray JJ cord-021413-1ht1xm88 138 12 - - HYPH cord-021413-1ht1xm88 138 13 green green JJ cord-021413-1ht1xm88 138 14 , , , cord-021413-1ht1xm88 138 15 with with IN cord-021413-1ht1xm88 138 16 no no DT cord-021413-1ht1xm88 138 17 formed form VBN cord-021413-1ht1xm88 138 18 feces fece NNS cord-021413-1ht1xm88 138 19 in in IN cord-021413-1ht1xm88 138 20 evi evi JJ cord-021413-1ht1xm88 138 21 dence dence NN cord-021413-1ht1xm88 138 22 . . . cord-021413-1ht1xm88 139 1 G g NN cord-021413-1ht1xm88 140 1 a a DT cord-021413-1ht1xm88 140 2 s s NN cord-021413-1ht1xm88 140 3 is be VBZ cord-021413-1ht1xm88 140 4 often often RB cord-021413-1ht1xm88 140 5 seen see VBN cord-021413-1ht1xm88 140 6 in in IN cord-021413-1ht1xm88 140 7 the the DT cord-021413-1ht1xm88 140 8 colon colon NN cord-021413-1ht1xm88 140 9 and and CC cord-021413-1ht1xm88 140 10 c c NN cord-021413-1ht1xm88 140 11 e e NN cord-021413-1ht1xm88 140 12 c c NN cord-021413-1ht1xm88 140 13 u u NNP cord-021413-1ht1xm88 140 14 m m NNP cord-021413-1ht1xm88 140 15 , , , cord-021413-1ht1xm88 140 16 which which WDT cord-021413-1ht1xm88 140 17 are be VBP cord-021413-1ht1xm88 140 18 distended distend VBN cord-021413-1ht1xm88 140 19 . . . cord-021413-1ht1xm88 141 1 T T NNP cord-021413-1ht1xm88 141 2 h h NN cord-021413-1ht1xm88 141 3 e e NN cord-021413-1ht1xm88 141 4 stomach stomach NN cord-021413-1ht1xm88 141 5 , , , cord-021413-1ht1xm88 141 6 t t NN cord-021413-1ht1xm88 141 7 o o NN cord-021413-1ht1xm88 141 8 o o NN cord-021413-1ht1xm88 141 9 , , , cord-021413-1ht1xm88 141 10 is be VBZ cord-021413-1ht1xm88 141 11 distended distend VBN cord-021413-1ht1xm88 141 12 with with IN cord-021413-1ht1xm88 141 13 curdled curdled JJ cord-021413-1ht1xm88 141 14 milk milk NN cord-021413-1ht1xm88 141 15 ( ( -LRB- cord-021413-1ht1xm88 141 16 except except IN cord-021413-1ht1xm88 141 17 in in IN cord-021413-1ht1xm88 141 18 terminal terminal JJ cord-021413-1ht1xm88 141 19 cases case NNS cord-021413-1ht1xm88 141 20 with with IN cord-021413-1ht1xm88 141 21 anal anal JJ cord-021413-1ht1xm88 141 22 impaction impaction NN cord-021413-1ht1xm88 141 23 ) ) -RRB- cord-021413-1ht1xm88 141 24 . . . cord-021413-1ht1xm88 142 1 All all DT cord-021413-1ht1xm88 142 2 other other JJ cord-021413-1ht1xm88 142 3 or or CC cord-021413-1ht1xm88 142 4 gans gans NNP cord-021413-1ht1xm88 142 5 appear appear VBP cord-021413-1ht1xm88 142 6 normal normal JJ cord-021413-1ht1xm88 142 7 . . . cord-021413-1ht1xm88 143 1 Gross gross JJ cord-021413-1ht1xm88 143 2 change change NN cord-021413-1ht1xm88 143 3 is be VBZ cord-021413-1ht1xm88 143 4 not not RB cord-021413-1ht1xm88 143 5 seen see VBN cord-021413-1ht1xm88 143 6 in in IN cord-021413-1ht1xm88 143 7 the the DT cord-021413-1ht1xm88 143 8 intestines intestine NNS cord-021413-1ht1xm88 143 9 of of IN cord-021413-1ht1xm88 143 10 adults adult NNS cord-021413-1ht1xm88 143 11 exposed expose VBN cord-021413-1ht1xm88 143 12 perorally perorally RB cord-021413-1ht1xm88 143 13 . . . cord-021413-1ht1xm88 144 1 It -PRON- PRP cord-021413-1ht1xm88 144 2 is be VBZ cord-021413-1ht1xm88 144 3 noteworthy noteworthy JJ cord-021413-1ht1xm88 144 4 that that IN cord-021413-1ht1xm88 144 5 in in IN cord-021413-1ht1xm88 144 6 germ germ NN cord-021413-1ht1xm88 144 7 - - HYPH cord-021413-1ht1xm88 144 8 free free JJ cord-021413-1ht1xm88 144 9 infant infant NN cord-021413-1ht1xm88 144 10 m m NN cord-021413-1ht1xm88 144 11 i i NN cord-021413-1ht1xm88 144 12 c c NNP cord-021413-1ht1xm88 144 13 e e NNP cord-021413-1ht1xm88 144 14 , , , cord-021413-1ht1xm88 144 15 ex ex FW cord-021413-1ht1xm88 144 16 perimental perimental FW cord-021413-1ht1xm88 144 17 E e NN cord-021413-1ht1xm88 144 18 D d NN cord-021413-1ht1xm88 144 19 I i NN cord-021413-1ht1xm88 144 20 M m CD cord-021413-1ht1xm88 144 21 virus virus NN cord-021413-1ht1xm88 144 22 infection infection NN cord-021413-1ht1xm88 144 23 appears appear VBZ cord-021413-1ht1xm88 144 24 in in IN cord-021413-1ht1xm88 144 25 the the DT cord-021413-1ht1xm88 144 26 gross gross NN cord-021413-1ht1xm88 144 27 as as IN cord-021413-1ht1xm88 144 28 it -PRON- PRP cord-021413-1ht1xm88 144 29 does do VBZ cord-021413-1ht1xm88 144 30 in in IN cord-021413-1ht1xm88 144 31 conventional conventional JJ cord-021413-1ht1xm88 144 32 mice mouse NNS cord-021413-1ht1xm88 144 33 ( ( -LRB- cord-021413-1ht1xm88 144 34 Kraft Kraft NNP cord-021413-1ht1xm88 144 35 , , , cord-021413-1ht1xm88 144 36 1966 1966 CD cord-021413-1ht1xm88 144 37 ) ) -RRB- cord-021413-1ht1xm88 144 38 . . . cord-021413-1ht1xm88 145 1 The the DT cord-021413-1ht1xm88 145 2 histologic histologic JJ cord-021413-1ht1xm88 145 3 picture picture NN cord-021413-1ht1xm88 145 4 has have VBZ cord-021413-1ht1xm88 145 5 been be VBN cord-021413-1ht1xm88 145 6 confirmed confirm VBN cord-021413-1ht1xm88 145 7 by by IN cord-021413-1ht1xm88 145 8 others other NNS cord-021413-1ht1xm88 145 9 ( ( -LRB- cord-021413-1ht1xm88 145 10 Adams Adams NNP cord-021413-1ht1xm88 145 11 and and CC cord-021413-1ht1xm88 145 12 Kraft Kraft NNP cord-021413-1ht1xm88 145 13 , , , cord-021413-1ht1xm88 145 14 1967 1967 CD cord-021413-1ht1xm88 145 15 ; ; : cord-021413-1ht1xm88 145 16 McClure McClure NNP cord-021413-1ht1xm88 145 17 et et NNP cord-021413-1ht1xm88 145 18 aL aL NNP cord-021413-1ht1xm88 145 19 , , , cord-021413-1ht1xm88 145 20 1978 1978 CD cord-021413-1ht1xm88 145 21 ) ) -RRB- cord-021413-1ht1xm88 145 22 . . . cord-021413-1ht1xm88 146 1 There there EX cord-021413-1ht1xm88 146 2 is be VBZ cord-021413-1ht1xm88 146 3 no no DT cord-021413-1ht1xm88 146 4 inflam inflam NNP cord-021413-1ht1xm88 146 5 matory matory NN cord-021413-1ht1xm88 146 6 reaction reaction NN cord-021413-1ht1xm88 146 7 in in IN cord-021413-1ht1xm88 146 8 the the DT cord-021413-1ht1xm88 146 9 intestines intestine NNS cord-021413-1ht1xm88 146 10 . . . cord-021413-1ht1xm88 147 1 Inclusions Inclusions NNP cord-021413-1ht1xm88 147 2 may may MD cord-021413-1ht1xm88 147 3 indeed indeed RB cord-021413-1ht1xm88 147 4 be be VB cord-021413-1ht1xm88 147 5 found find VBN cord-021413-1ht1xm88 147 6 in in IN cord-021413-1ht1xm88 147 7 enterocytes enterocyte NNS cord-021413-1ht1xm88 147 8 near near IN cord-021413-1ht1xm88 147 9 the the DT cord-021413-1ht1xm88 147 10 tips tip NNS cord-021413-1ht1xm88 147 11 of of IN cord-021413-1ht1xm88 147 12 villi villi NN cord-021413-1ht1xm88 147 13 , , , cord-021413-1ht1xm88 147 14 especially especially RB cord-021413-1ht1xm88 147 15 in in IN cord-021413-1ht1xm88 147 16 the the DT cord-021413-1ht1xm88 147 17 jejunum jejunum NN cord-021413-1ht1xm88 147 18 , , , cord-021413-1ht1xm88 147 19 and and CC cord-021413-1ht1xm88 147 20 infrequently infrequently RB cord-021413-1ht1xm88 147 21 in in IN cord-021413-1ht1xm88 147 22 the the DT cord-021413-1ht1xm88 147 23 sloughed slough VBN cord-021413-1ht1xm88 147 24 cells cell NNS cord-021413-1ht1xm88 147 25 seen see VBN cord-021413-1ht1xm88 147 26 in in IN cord-021413-1ht1xm88 147 27 the the DT cord-021413-1ht1xm88 147 28 lumen lumen NN cord-021413-1ht1xm88 147 29 . . . cord-021413-1ht1xm88 148 1 Epithelial epithelial JJ cord-021413-1ht1xm88 148 2 cells cell NNS cord-021413-1ht1xm88 148 3 near near RB cord-021413-1ht1xm88 148 4 and and CC cord-021413-1ht1xm88 148 5 at at IN cord-021413-1ht1xm88 148 6 the the DT cord-021413-1ht1xm88 148 7 tips tip NNS cord-021413-1ht1xm88 148 8 of of IN cord-021413-1ht1xm88 148 9 villi villus NNS cord-021413-1ht1xm88 148 10 are be VBP cord-021413-1ht1xm88 148 11 fre fre NNP cord-021413-1ht1xm88 148 12 quently quently RB cord-021413-1ht1xm88 148 13 vacuolated vacuolated JJ cord-021413-1ht1xm88 148 14 . . . cord-021413-1ht1xm88 149 1 Acres Acres NNP cord-021413-1ht1xm88 149 2 and and CC cord-021413-1ht1xm88 149 3 Babiuk Babiuk NNP cord-021413-1ht1xm88 149 4 ( ( -LRB- cord-021413-1ht1xm88 149 5 1978 1978 CD cord-021413-1ht1xm88 149 6 ) ) -RRB- cord-021413-1ht1xm88 149 7 have have VBP cord-021413-1ht1xm88 149 8 pointed point VBN cord-021413-1ht1xm88 149 9 out out RP cord-021413-1ht1xm88 149 10 that that IN cord-021413-1ht1xm88 149 11 in in IN cord-021413-1ht1xm88 149 12 all all DT cord-021413-1ht1xm88 149 13 species specie NNS cord-021413-1ht1xm88 149 14 studied study VBN cord-021413-1ht1xm88 149 15 , , , cord-021413-1ht1xm88 149 16 the the DT cord-021413-1ht1xm88 149 17 rotaviruses rotavirus NNS cord-021413-1ht1xm88 149 18 cause cause VBP cord-021413-1ht1xm88 149 19 diarrhea diarrhea NN cord-021413-1ht1xm88 149 20 by by IN cord-021413-1ht1xm88 149 21 attacking attack VBG cord-021413-1ht1xm88 149 22 and and CC cord-021413-1ht1xm88 149 23 de de IN cord-021413-1ht1xm88 149 24 stroying stroye VBG cord-021413-1ht1xm88 149 25 the the DT cord-021413-1ht1xm88 149 26 columnar columnar JJ cord-021413-1ht1xm88 149 27 epithelium epithelium NN cord-021413-1ht1xm88 149 28 of of IN cord-021413-1ht1xm88 149 29 the the DT cord-021413-1ht1xm88 149 30 small small JJ cord-021413-1ht1xm88 149 31 intestine intestine NN cord-021413-1ht1xm88 149 32 . . . cord-021413-1ht1xm88 150 1 Middleton Middleton NNP cord-021413-1ht1xm88 150 2 ( ( -LRB- cord-021413-1ht1xm88 150 3 1978 1978 CD cord-021413-1ht1xm88 150 4 ) ) -RRB- cord-021413-1ht1xm88 150 5 considers consider VBZ cord-021413-1ht1xm88 150 6 that that DT cord-021413-1ht1xm88 150 7 cell cell NN cord-021413-1ht1xm88 150 8 migration migration NN cord-021413-1ht1xm88 150 9 from from IN cord-021413-1ht1xm88 150 10 the the DT cord-021413-1ht1xm88 150 11 crypts crypt NNS cord-021413-1ht1xm88 150 12 is be VBZ cord-021413-1ht1xm88 150 13 speeded speed VBN cord-021413-1ht1xm88 150 14 in in IN cord-021413-1ht1xm88 150 15 response response NN cord-021413-1ht1xm88 150 16 to to IN cord-021413-1ht1xm88 150 17 diarrhea diarrhea NN cord-021413-1ht1xm88 150 18 and and CC cord-021413-1ht1xm88 150 19 that that IN cord-021413-1ht1xm88 150 20 the the DT cord-021413-1ht1xm88 150 21 infected infected JJ cord-021413-1ht1xm88 150 22 cells cell NNS cord-021413-1ht1xm88 150 23 are be VBP cord-021413-1ht1xm88 150 24 relatively relatively RB cord-021413-1ht1xm88 150 25 immature immature JJ cord-021413-1ht1xm88 150 26 . . . cord-021413-1ht1xm88 151 1 Enzyme enzyme NN cord-021413-1ht1xm88 151 2 levels level NNS cord-021413-1ht1xm88 151 3 , , , cord-021413-1ht1xm88 151 4 high high JJ cord-021413-1ht1xm88 151 5 thymidine thymidine NN cord-021413-1ht1xm88 151 6 kinase kinase NN cord-021413-1ht1xm88 151 7 and and CC cord-021413-1ht1xm88 151 8 low low JJ cord-021413-1ht1xm88 151 9 sucrase sucrase NN cord-021413-1ht1xm88 151 10 , , , cord-021413-1ht1xm88 151 11 are be VBP cord-021413-1ht1xm88 151 12 similar similar JJ cord-021413-1ht1xm88 151 13 in in IN cord-021413-1ht1xm88 151 14 such such JJ cord-021413-1ht1xm88 151 15 cells cell NNS cord-021413-1ht1xm88 151 16 to to IN cord-021413-1ht1xm88 151 17 those those DT cord-021413-1ht1xm88 151 18 of of IN cord-021413-1ht1xm88 151 19 normal normal JJ cord-021413-1ht1xm88 151 20 crypt crypt NN cord-021413-1ht1xm88 151 21 cells cell NNS cord-021413-1ht1xm88 151 22 and and CC cord-021413-1ht1xm88 151 23 thus thus RB cord-021413-1ht1xm88 151 24 support support VBP cord-021413-1ht1xm88 151 25 this this DT cord-021413-1ht1xm88 151 26 view view NN cord-021413-1ht1xm88 151 27 . . . cord-021413-1ht1xm88 152 1 The the DT cord-021413-1ht1xm88 152 2 microscopic microscopic JJ cord-021413-1ht1xm88 152 3 appearance appearance NN cord-021413-1ht1xm88 152 4 belies belie VBZ cord-021413-1ht1xm88 152 5 the the DT cord-021413-1ht1xm88 152 6 severity severity NN cord-021413-1ht1xm88 152 7 of of IN cord-021413-1ht1xm88 152 8 the the DT cord-021413-1ht1xm88 152 9 gross gross JJ cord-021413-1ht1xm88 152 10 and and CC cord-021413-1ht1xm88 152 11 clinical clinical JJ cord-021413-1ht1xm88 152 12 findings finding NNS cord-021413-1ht1xm88 152 13 of of IN cord-021413-1ht1xm88 152 14 EDIM EDIM NNS cord-021413-1ht1xm88 152 15 . . . cord-021413-1ht1xm88 153 1 In in IN cord-021413-1ht1xm88 153 2 this this DT cord-021413-1ht1xm88 153 3 regard regard NN cord-021413-1ht1xm88 153 4 , , , cord-021413-1ht1xm88 153 5 D D NNP cord-021413-1ht1xm88 153 6 - - HYPH cord-021413-1ht1xm88 153 7 xylose xylose NNP cord-021413-1ht1xm88 153 8 absorp absorp NNP cord-021413-1ht1xm88 153 9 tion tion NNP cord-021413-1ht1xm88 153 10 has have VBZ cord-021413-1ht1xm88 153 11 been be VBN cord-021413-1ht1xm88 153 12 studied study VBN cord-021413-1ht1xm88 153 13 in in IN cord-021413-1ht1xm88 153 14 calves calf NNS cord-021413-1ht1xm88 153 15 in in IN cord-021413-1ht1xm88 153 16 which which WDT cord-021413-1ht1xm88 153 17 60 60 CD cord-021413-1ht1xm88 153 18 - - SYM cord-021413-1ht1xm88 153 19 90 90 CD cord-021413-1ht1xm88 153 20 % % NN cord-021413-1ht1xm88 153 21 reduction reduction NN cord-021413-1ht1xm88 153 22 occurred occur VBD cord-021413-1ht1xm88 153 23 during during IN cord-021413-1ht1xm88 153 24 the the DT cord-021413-1ht1xm88 153 25 acute acute JJ cord-021413-1ht1xm88 153 26 illness illness NN cord-021413-1ht1xm88 153 27 with with IN cord-021413-1ht1xm88 153 28 the the DT cord-021413-1ht1xm88 153 29 calf calf NN cord-021413-1ht1xm88 153 30 rotavirus rotavirus NN cord-021413-1ht1xm88 153 31 . . . cord-021413-1ht1xm88 154 1 Aberrations aberration NNS cord-021413-1ht1xm88 154 2 in in IN cord-021413-1ht1xm88 154 3 sodium sodium NN cord-021413-1ht1xm88 154 4 transport transport NN cord-021413-1ht1xm88 154 5 have have VBP cord-021413-1ht1xm88 154 6 also also RB cord-021413-1ht1xm88 154 7 been be VBN cord-021413-1ht1xm88 154 8 investigated investigate VBN cord-021413-1ht1xm88 154 9 in in IN cord-021413-1ht1xm88 154 10 other other JJ cord-021413-1ht1xm88 154 11 animals animal NNS cord-021413-1ht1xm88 154 12 and and CC cord-021413-1ht1xm88 154 13 in in IN cord-021413-1ht1xm88 154 14 humans human NNS cord-021413-1ht1xm88 154 15 ( ( -LRB- cord-021413-1ht1xm88 154 16 Middleton Middleton NNP cord-021413-1ht1xm88 154 17 , , , cord-021413-1ht1xm88 154 18 1978 1978 CD cord-021413-1ht1xm88 154 19 ) ) -RRB- cord-021413-1ht1xm88 154 20 , , , cord-021413-1ht1xm88 154 21 but but CC cord-021413-1ht1xm88 154 22 such such JJ cord-021413-1ht1xm88 154 23 studies study NNS cord-021413-1ht1xm88 154 24 have have VBP cord-021413-1ht1xm88 154 25 not not RB cord-021413-1ht1xm88 154 26 been be VBN cord-021413-1ht1xm88 154 27 carried carry VBN cord-021413-1ht1xm88 154 28 out out RP cord-021413-1ht1xm88 154 29 in in IN cord-021413-1ht1xm88 154 30 mice mouse NNS cord-021413-1ht1xm88 154 31 using use VBG cord-021413-1ht1xm88 154 32 the the DT cord-021413-1ht1xm88 154 33 mouse mouse NN cord-021413-1ht1xm88 154 34 agent agent NN cord-021413-1ht1xm88 154 35 . . . cord-021413-1ht1xm88 155 1 Cheever Cheever NNP cord-021413-1ht1xm88 155 2 and and CC cord-021413-1ht1xm88 155 3 Mueller Mueller NNP cord-021413-1ht1xm88 155 4 ( ( -LRB- cord-021413-1ht1xm88 155 5 1947 1947 CD cord-021413-1ht1xm88 155 6 ) ) -RRB- cord-021413-1ht1xm88 155 7 and and CC cord-021413-1ht1xm88 155 8 Kraft Kraft NNP cord-021413-1ht1xm88 155 9 ( ( -LRB- cord-021413-1ht1xm88 155 10 1957 1957 CD cord-021413-1ht1xm88 155 11 ) ) -RRB- cord-021413-1ht1xm88 155 12 demonstrated demonstrate VBD cord-021413-1ht1xm88 155 13 that that IN cord-021413-1ht1xm88 155 14 the the DT cord-021413-1ht1xm88 155 15 agent agent NN cord-021413-1ht1xm88 155 16 is be VBZ cord-021413-1ht1xm88 155 17 transmissible transmissible JJ cord-021413-1ht1xm88 155 18 perorally perorally RB cord-021413-1ht1xm88 155 19 . . . cord-021413-1ht1xm88 156 1 Kraft Kraft NNP cord-021413-1ht1xm88 156 2 ( ( -LRB- cord-021413-1ht1xm88 156 3 1957 1957 CD cord-021413-1ht1xm88 156 4 ) ) -RRB- cord-021413-1ht1xm88 156 5 showed show VBD cord-021413-1ht1xm88 156 6 further further RB cord-021413-1ht1xm88 156 7 that that IN cord-021413-1ht1xm88 156 8 dissemination dissemination NN cord-021413-1ht1xm88 156 9 in in IN cord-021413-1ht1xm88 156 10 a a DT cord-021413-1ht1xm88 156 11 mouse mouse NN cord-021413-1ht1xm88 156 12 colony colony NN cord-021413-1ht1xm88 156 13 is be VBZ cord-021413-1ht1xm88 156 14 mediated mediate VBN cord-021413-1ht1xm88 156 15 prin prin NN cord-021413-1ht1xm88 156 16 cipally cipally NN cord-021413-1ht1xm88 156 17 by by IN cord-021413-1ht1xm88 156 18 the the DT cord-021413-1ht1xm88 156 19 airborne airborne JJ cord-021413-1ht1xm88 156 20 route route NN cord-021413-1ht1xm88 156 21 . . . cord-021413-1ht1xm88 157 1 Kraft Kraft NNP cord-021413-1ht1xm88 157 2 ( ( -LRB- cord-021413-1ht1xm88 157 3 1961 1961 CD cord-021413-1ht1xm88 157 4 ) ) -RRB- cord-021413-1ht1xm88 157 5 examined examine VBD cord-021413-1ht1xm88 157 6 the the DT cord-021413-1ht1xm88 157 7 neutralization neutralization NN cord-021413-1ht1xm88 157 8 test test NN cord-021413-1ht1xm88 157 9 in in IN cord-021413-1ht1xm88 157 10 EDIM EDIM NNP cord-021413-1ht1xm88 157 11 and and CC cord-021413-1ht1xm88 157 12 found find VBD cord-021413-1ht1xm88 157 13 that that IN cord-021413-1ht1xm88 157 14 antibodies antibody NNS cord-021413-1ht1xm88 157 15 were be VBD cord-021413-1ht1xm88 157 16 not not RB cord-021413-1ht1xm88 157 17 always always RB cord-021413-1ht1xm88 157 18 formed form VBN cord-021413-1ht1xm88 157 19 following follow VBG cord-021413-1ht1xm88 157 20 infec infec IN cord-021413-1ht1xm88 157 21 tion tion NN cord-021413-1ht1xm88 157 22 , , , cord-021413-1ht1xm88 157 23 and and CC cord-021413-1ht1xm88 157 24 when when WRB cord-021413-1ht1xm88 157 25 they -PRON- PRP cord-021413-1ht1xm88 157 26 were be VBD cord-021413-1ht1xm88 157 27 present present JJ cord-021413-1ht1xm88 157 28 , , , cord-021413-1ht1xm88 157 29 they -PRON- PRP cord-021413-1ht1xm88 157 30 tended tend VBD cord-021413-1ht1xm88 157 31 to to TO cord-021413-1ht1xm88 157 32 be be VB cord-021413-1ht1xm88 157 33 low low JJ cord-021413-1ht1xm88 157 34 in in IN cord-021413-1ht1xm88 157 35 titer titer NN cord-021413-1ht1xm88 157 36 . . . cord-021413-1ht1xm88 158 1 Sera Sera NNP cord-021413-1ht1xm88 158 2 from from IN cord-021413-1ht1xm88 158 3 adult adult NN cord-021413-1ht1xm88 158 4 mice mouse NNS cord-021413-1ht1xm88 158 5 having have VBG cord-021413-1ht1xm88 158 6 had have VBD cord-021413-1ht1xm88 158 7 lifelong lifelong JJ cord-021413-1ht1xm88 158 8 contact contact NN cord-021413-1ht1xm88 158 9 with with IN cord-021413-1ht1xm88 158 10 the the DT cord-021413-1ht1xm88 158 11 agent agent NN cord-021413-1ht1xm88 158 12 ( ( -LRB- cord-021413-1ht1xm88 158 13 in in IN cord-021413-1ht1xm88 158 14 the the DT cord-021413-1ht1xm88 158 15 form form NN cord-021413-1ht1xm88 158 16 of of IN cord-021413-1ht1xm88 158 17 consistently consistently RB cord-021413-1ht1xm88 158 18 diarrheal diarrheal JJ cord-021413-1ht1xm88 158 19 litters litter NNS cord-021413-1ht1xm88 158 20 ) ) -RRB- cord-021413-1ht1xm88 158 21 were be VBD cord-021413-1ht1xm88 158 22 more more RBR cord-021413-1ht1xm88 158 23 apt apt JJ cord-021413-1ht1xm88 158 24 to to TO cord-021413-1ht1xm88 158 25 neutralize neutralize VB cord-021413-1ht1xm88 158 26 the the DT cord-021413-1ht1xm88 158 27 virus virus NN cord-021413-1ht1xm88 158 28 than than IN cord-021413-1ht1xm88 158 29 those those DT cord-021413-1ht1xm88 158 30 of of IN cord-021413-1ht1xm88 158 31 mice mouse NNS cord-021413-1ht1xm88 158 32 exposed expose VBN cord-021413-1ht1xm88 158 33 for for IN cord-021413-1ht1xm88 158 34 the the DT cord-021413-1ht1xm88 158 35 first first JJ cord-021413-1ht1xm88 158 36 time time NN cord-021413-1ht1xm88 158 37 as as IN cord-021413-1ht1xm88 158 38 adults adult NNS cord-021413-1ht1xm88 158 39 . . . cord-021413-1ht1xm88 159 1 On on IN cord-021413-1ht1xm88 159 2 the the DT cord-021413-1ht1xm88 159 3 other other JJ cord-021413-1ht1xm88 159 4 hand hand NN cord-021413-1ht1xm88 159 5 , , , cord-021413-1ht1xm88 159 6 hyperimmunization hyperimmunization NN cord-021413-1ht1xm88 159 7 of of IN cord-021413-1ht1xm88 159 8 mice mouse NNS cord-021413-1ht1xm88 159 9 has have VBZ cord-021413-1ht1xm88 159 10 resulted result VBN cord-021413-1ht1xm88 159 11 in in IN cord-021413-1ht1xm88 159 12 the the DT cord-021413-1ht1xm88 159 13 production production NN cord-021413-1ht1xm88 159 14 of of IN cord-021413-1ht1xm88 159 15 significant significant JJ cord-021413-1ht1xm88 159 16 serum serum NN cord-021413-1ht1xm88 159 17 titers titer NNS cord-021413-1ht1xm88 159 18 of of IN cord-021413-1ht1xm88 159 19 both both DT cord-021413-1ht1xm88 159 20 complement complement NN cord-021413-1ht1xm88 159 21 - - HYPH cord-021413-1ht1xm88 159 22 fixing fix VBG cord-021413-1ht1xm88 159 23 and and CC cord-021413-1ht1xm88 159 24 neutralizing neutralize VBG cord-021413-1ht1xm88 159 25 antibodies antibody NNS cord-021413-1ht1xm88 159 26 ( ( -LRB- cord-021413-1ht1xm88 159 27 Blackwell Blackwell NNP cord-021413-1ht1xm88 159 28 etaL etaL NNP cord-021413-1ht1xm88 159 29 , , , cord-021413-1ht1xm88 159 30 1966 1966 CD cord-021413-1ht1xm88 159 31 ) ) -RRB- cord-021413-1ht1xm88 159 32 . . . cord-021413-1ht1xm88 160 1 Antibody antibody NN cord-021413-1ht1xm88 160 2 response response NN cord-021413-1ht1xm88 160 3 measured measure VBN cord-021413-1ht1xm88 160 4 by by IN cord-021413-1ht1xm88 160 5 other other JJ cord-021413-1ht1xm88 160 6 serologic serologic NN cord-021413-1ht1xm88 160 7 tests test NNS cord-021413-1ht1xm88 160 8 has have VBZ cord-021413-1ht1xm88 160 9 not not RB cord-021413-1ht1xm88 160 10 been be VBN cord-021413-1ht1xm88 160 11 investigated investigate VBN cord-021413-1ht1xm88 160 12 for for IN cord-021413-1ht1xm88 160 13 EDIM EDIM NNP cord-021413-1ht1xm88 160 14 , , , cord-021413-1ht1xm88 160 15 nor nor CC cord-021413-1ht1xm88 160 16 have have VBP cord-021413-1ht1xm88 160 17 immune immune JJ cord-021413-1ht1xm88 160 18 substances substance NNS cord-021413-1ht1xm88 160 19 in in IN cord-021413-1ht1xm88 160 20 lacteal lacteal JJ cord-021413-1ht1xm88 160 21 secretions secretion NNS cord-021413-1ht1xm88 160 22 been be VBN cord-021413-1ht1xm88 160 23 measured measure VBN cord-021413-1ht1xm88 160 24 directly directly RB cord-021413-1ht1xm88 160 25 . . . cord-021413-1ht1xm88 161 1 Suggestive suggestive JJ cord-021413-1ht1xm88 161 2 of of IN cord-021413-1ht1xm88 161 3 their -PRON- PRP$ cord-021413-1ht1xm88 161 4 presence presence NN cord-021413-1ht1xm88 161 5 , , , cord-021413-1ht1xm88 161 6 however however RB cord-021413-1ht1xm88 161 7 , , , cord-021413-1ht1xm88 161 8 are be VBP cord-021413-1ht1xm88 161 9 data datum NNS cord-021413-1ht1xm88 161 10 showing show VBG cord-021413-1ht1xm88 161 11 that that IN cord-021413-1ht1xm88 161 12 infants infant NNS cord-021413-1ht1xm88 161 13 of of IN cord-021413-1ht1xm88 161 14 primiparae primiparae NNP cord-021413-1ht1xm88 161 15 who who WP cord-021413-1ht1xm88 161 16 themselves -PRON- PRP cord-021413-1ht1xm88 161 17 had have VBD cord-021413-1ht1xm88 161 18 been be VBN cord-021413-1ht1xm88 161 19 diarrheal diarrheal JJ cord-021413-1ht1xm88 161 20 in in IN cord-021413-1ht1xm88 161 21 infancy infancy NN cord-021413-1ht1xm88 161 22 resisted resist VBD cord-021413-1ht1xm88 161 23 about about IN cord-021413-1ht1xm88 161 24 10 10 CD cord-021413-1ht1xm88 161 25 ID50 ID50 NNP cord-021413-1ht1xm88 161 26 more more JJR cord-021413-1ht1xm88 161 27 of of IN cord-021413-1ht1xm88 161 28 EDIM EDIM NNP cord-021413-1ht1xm88 161 29 virus virus NN cord-021413-1ht1xm88 161 30 than than IN cord-021413-1ht1xm88 161 31 did do VBD cord-021413-1ht1xm88 161 32 offspring offspring NN cord-021413-1ht1xm88 161 33 of of IN cord-021413-1ht1xm88 161 34 previously previously JJ cord-021413-1ht1xm88 161 35 nondiarrheal nondiarrheal NN cord-021413-1ht1xm88 161 36 dams dam NNS cord-021413-1ht1xm88 161 37 ( ( -LRB- cord-021413-1ht1xm88 161 38 Kraft Kraft NNP cord-021413-1ht1xm88 161 39 , , , cord-021413-1ht1xm88 161 40 1961 1961 CD cord-021413-1ht1xm88 161 41 ) ) -RRB- cord-021413-1ht1xm88 161 42 . . . cord-021413-1ht1xm88 162 1 Antirotaviral Antirotaviral NNP cord-021413-1ht1xm88 162 2 immunoglobu immunoglobu NNP cord-021413-1ht1xm88 162 3 lins lins NNP cord-021413-1ht1xm88 162 4 have have VBP cord-021413-1ht1xm88 162 5 been be VBN cord-021413-1ht1xm88 162 6 found find VBN cord-021413-1ht1xm88 162 7 in in IN cord-021413-1ht1xm88 162 8 both both DT cord-021413-1ht1xm88 162 9 colostrum colostrum NN cord-021413-1ht1xm88 162 10 and and CC cord-021413-1ht1xm88 162 11 milk milk NN cord-021413-1ht1xm88 162 12 in in IN cord-021413-1ht1xm88 162 13 man man NN cord-021413-1ht1xm88 162 14 ( ( -LRB- cord-021413-1ht1xm88 162 15 Yolken Yolken NNP cord-021413-1ht1xm88 162 16 et et FW cord-021413-1ht1xm88 162 17 aL aL NNP cord-021413-1ht1xm88 162 18 , , , cord-021413-1ht1xm88 162 19 1978c 1978c CD cord-021413-1ht1xm88 162 20 ; ; : cord-021413-1ht1xm88 162 21 Simhon Simhon NNP cord-021413-1ht1xm88 162 22 and and CC cord-021413-1ht1xm88 162 23 Mata Mata NNP cord-021413-1ht1xm88 162 24 , , , cord-021413-1ht1xm88 162 25 1978 1978 CD cord-021413-1ht1xm88 162 26 ; ; : cord-021413-1ht1xm88 162 27 Thouless Thouless NNP cord-021413-1ht1xm88 162 28 et et NNP cord-021413-1ht1xm88 162 29 aL aL NNP cord-021413-1ht1xm88 162 30 , , , cord-021413-1ht1xm88 162 31 1977a 1977a CD cord-021413-1ht1xm88 162 32 ) ) -RRB- cord-021413-1ht1xm88 162 33 , , , cord-021413-1ht1xm88 162 34 bovines bovine NNS cord-021413-1ht1xm88 162 35 ( ( -LRB- cord-021413-1ht1xm88 162 36 Acres Acres NNP cord-021413-1ht1xm88 162 37 and and CC cord-021413-1ht1xm88 162 38 Babiuk Babiuk NNP cord-021413-1ht1xm88 162 39 , , , cord-021413-1ht1xm88 162 40 1978 1978 CD cord-021413-1ht1xm88 162 41 ) ) -RRB- cord-021413-1ht1xm88 162 42 , , , cord-021413-1ht1xm88 162 43 and and CC cord-021413-1ht1xm88 162 44 lambs lamb NNS cord-021413-1ht1xm88 162 45 ( ( -LRB- cord-021413-1ht1xm88 162 46 Snodgrass Snodgrass NNP cord-021413-1ht1xm88 162 47 and and CC cord-021413-1ht1xm88 162 48 Wells Wells NNP cord-021413-1ht1xm88 162 49 , , , cord-021413-1ht1xm88 162 50 1976 1976 CD cord-021413-1ht1xm88 162 51 ) ) -RRB- cord-021413-1ht1xm88 162 52 . . . cord-021413-1ht1xm88 163 1 Indeed indeed RB cord-021413-1ht1xm88 163 2 , , , cord-021413-1ht1xm88 163 3 local local JJ cord-021413-1ht1xm88 163 4 immunity immunity NN cord-021413-1ht1xm88 163 5 afforded afford VBN cord-021413-1ht1xm88 163 6 by by IN cord-021413-1ht1xm88 163 7 lacteal lacteal JJ cord-021413-1ht1xm88 163 8 immune immune JJ cord-021413-1ht1xm88 163 9 substances substance NNS cord-021413-1ht1xm88 163 10 is be VBZ cord-021413-1ht1xm88 163 11 regarded regard VBN cord-021413-1ht1xm88 163 12 as as IN cord-021413-1ht1xm88 163 13 crucial crucial JJ cord-021413-1ht1xm88 163 14 for for IN cord-021413-1ht1xm88 163 15 protection protection NN cord-021413-1ht1xm88 163 16 against against IN cord-021413-1ht1xm88 163 17 any any DT cord-021413-1ht1xm88 163 18 intestinal intestinal JJ cord-021413-1ht1xm88 163 19 infection infection NN cord-021413-1ht1xm88 163 20 in in IN cord-021413-1ht1xm88 163 21 the the DT cord-021413-1ht1xm88 163 22 young young JJ cord-021413-1ht1xm88 163 23 ( ( -LRB- cord-021413-1ht1xm88 163 24 Welliver Welliver NNP cord-021413-1ht1xm88 163 25 and and CC cord-021413-1ht1xm88 163 26 Ogra Ogra NNP cord-021413-1ht1xm88 163 27 , , , cord-021413-1ht1xm88 163 28 1978 1978 CD cord-021413-1ht1xm88 163 29 ; ; : cord-021413-1ht1xm88 163 30 Snodgrass Snodgrass NNP cord-021413-1ht1xm88 163 31 and and CC cord-021413-1ht1xm88 163 32 Wells Wells NNP cord-021413-1ht1xm88 163 33 , , , cord-021413-1ht1xm88 163 34 1976 1976 CD cord-021413-1ht1xm88 163 35 _SP cord-021413-1ht1xm88 164 1 As as IN cord-021413-1ht1xm88 164 2 indicated indicate VBN cord-021413-1ht1xm88 164 3 , , , cord-021413-1ht1xm88 164 4 mice mouse NNS cord-021413-1ht1xm88 164 5 of of IN cord-021413-1ht1xm88 164 6 all all DT cord-021413-1ht1xm88 164 7 ages age NNS cord-021413-1ht1xm88 164 8 can can MD cord-021413-1ht1xm88 164 9 be be VB cord-021413-1ht1xm88 164 10 infected infect VBN cord-021413-1ht1xm88 164 11 , , , cord-021413-1ht1xm88 164 12 but but CC cord-021413-1ht1xm88 164 13 overt overt JJ cord-021413-1ht1xm88 164 14 disease disease NN cord-021413-1ht1xm88 164 15 is be VBZ cord-021413-1ht1xm88 164 16 restricted restrict VBN cord-021413-1ht1xm88 164 17 to to IN cord-021413-1ht1xm88 164 18 animals animal NNS cord-021413-1ht1xm88 164 19 up up IN cord-021413-1ht1xm88 164 20 to to IN cord-021413-1ht1xm88 164 21 about about RB cord-021413-1ht1xm88 164 22 12 12 CD cord-021413-1ht1xm88 164 23 - - SYM cord-021413-1ht1xm88 164 24 13 13 CD cord-021413-1ht1xm88 164 25 days day NNS cord-021413-1ht1xm88 164 26 of of IN cord-021413-1ht1xm88 164 27 age age NN cord-021413-1ht1xm88 164 28 at at IN cord-021413-1ht1xm88 164 29 the the DT cord-021413-1ht1xm88 164 30 time time NN cord-021413-1ht1xm88 164 31 of of IN cord-021413-1ht1xm88 164 32 first first JJ cord-021413-1ht1xm88 164 33 exposure exposure NN cord-021413-1ht1xm88 164 34 . . . cord-021413-1ht1xm88 165 1 There there EX cord-021413-1ht1xm88 165 2 seems seem VBZ cord-021413-1ht1xm88 165 3 to to TO cord-021413-1ht1xm88 165 4 be be VB cord-021413-1ht1xm88 165 5 no no DT cord-021413-1ht1xm88 165 6 predilection predilection NN cord-021413-1ht1xm88 165 7 for for IN cord-021413-1ht1xm88 165 8 a a DT cord-021413-1ht1xm88 165 9 particular particular JJ cord-021413-1ht1xm88 165 10 sex sex NN cord-021413-1ht1xm88 165 11 . . . cord-021413-1ht1xm88 166 1 The the DT cord-021413-1ht1xm88 166 2 observation observation NN cord-021413-1ht1xm88 166 3 that that IN cord-021413-1ht1xm88 166 4 first first JJ cord-021413-1ht1xm88 166 5 litters litter NNS cord-021413-1ht1xm88 166 6 are be VBP cord-021413-1ht1xm88 166 7 more more RBR cord-021413-1ht1xm88 166 8 apt apt JJ cord-021413-1ht1xm88 166 9 to to TO cord-021413-1ht1xm88 166 10 show show VB cord-021413-1ht1xm88 166 11 copious copious JJ cord-021413-1ht1xm88 166 12 and and CC cord-021413-1ht1xm88 166 13 protracted protracted JJ cord-021413-1ht1xm88 166 14 soiling soiling NN cord-021413-1ht1xm88 166 15 than than IN cord-021413-1ht1xm88 166 16 those those DT cord-021413-1ht1xm88 166 17 of of IN cord-021413-1ht1xm88 166 18 later later JJ cord-021413-1ht1xm88 166 19 parity parity NN cord-021413-1ht1xm88 166 20 has have VBZ cord-021413-1ht1xm88 166 21 been be VBN cord-021413-1ht1xm88 166 22 reported report VBN cord-021413-1ht1xm88 166 23 by by IN cord-021413-1ht1xm88 166 24 Cheever Cheever NNP cord-021413-1ht1xm88 166 25 and and CC cord-021413-1ht1xm88 166 26 Mueller Mueller NNP cord-021413-1ht1xm88 166 27 ( ( -LRB- cord-021413-1ht1xm88 166 28 1947 1947 CD cord-021413-1ht1xm88 166 29 , , , cord-021413-1ht1xm88 166 30 1948 1948 CD cord-021413-1ht1xm88 166 31 ) ) -RRB- cord-021413-1ht1xm88 166 32 and and CC cord-021413-1ht1xm88 166 33 by by IN cord-021413-1ht1xm88 166 34 Runner Runner NNP cord-021413-1ht1xm88 166 35 and and CC cord-021413-1ht1xm88 166 36 Palm Palm NNP cord-021413-1ht1xm88 166 37 ( ( -LRB- cord-021413-1ht1xm88 166 38 1953 1953 CD cord-021413-1ht1xm88 166 39 _SP cord-021413-1ht1xm88 166 40 EDIM EDIM NNP cord-021413-1ht1xm88 166 41 Virus Virus NNP cord-021413-1ht1xm88 166 42 is be VBZ cord-021413-1ht1xm88 166 43 probably probably RB cord-021413-1ht1xm88 166 44 worldwide worldwide RB cord-021413-1ht1xm88 166 45 in in IN cord-021413-1ht1xm88 166 46 distribution distribution NN cord-021413-1ht1xm88 166 47 . . . cord-021413-1ht1xm88 167 1 Whether whether IN cord-021413-1ht1xm88 167 2 it -PRON- PRP cord-021413-1ht1xm88 167 3 occurs occur VBZ cord-021413-1ht1xm88 167 4 in in IN cord-021413-1ht1xm88 167 5 wild wild JJ cord-021413-1ht1xm88 167 6 mouse mouse NN cord-021413-1ht1xm88 167 7 populations population NNS cord-021413-1ht1xm88 167 8 is be VBZ cord-021413-1ht1xm88 167 9 unknown unknown JJ cord-021413-1ht1xm88 167 10 . . . cord-021413-1ht1xm88 168 1 Its -PRON- PRP$ cord-021413-1ht1xm88 168 2 prevalence prevalence NN cord-021413-1ht1xm88 168 3 is be VBZ cord-021413-1ht1xm88 168 4 difficult difficult JJ cord-021413-1ht1xm88 168 5 to to TO cord-021413-1ht1xm88 168 6 estimate estimate VB cord-021413-1ht1xm88 168 7 , , , cord-021413-1ht1xm88 168 8 since since IN cord-021413-1ht1xm88 168 9 serologic serologic JJ cord-021413-1ht1xm88 168 10 tests test NNS cord-021413-1ht1xm88 168 11 have have VBP cord-021413-1ht1xm88 168 12 not not RB cord-021413-1ht1xm88 168 13 been be VBN cord-021413-1ht1xm88 168 14 readily readily RB cord-021413-1ht1xm88 168 15 available available JJ cord-021413-1ht1xm88 168 16 , , , cord-021413-1ht1xm88 168 17 and and CC cord-021413-1ht1xm88 168 18 it -PRON- PRP cord-021413-1ht1xm88 168 19 is be VBZ cord-021413-1ht1xm88 168 20 not not RB cord-021413-1ht1xm88 168 21 customary customary JJ cord-021413-1ht1xm88 168 22 to to TO cord-021413-1ht1xm88 168 23 sacrifice sacrifice VB cord-021413-1ht1xm88 168 24 animals animal NNS cord-021413-1ht1xm88 168 25 for for IN cord-021413-1ht1xm88 168 26 the the DT cord-021413-1ht1xm88 168 27 purpose purpose NN cord-021413-1ht1xm88 168 28 of of IN cord-021413-1ht1xm88 168 29 examining examine VBG cord-021413-1ht1xm88 168 30 the the DT cord-021413-1ht1xm88 168 31 appearance appearance NN cord-021413-1ht1xm88 168 32 of of IN cord-021413-1ht1xm88 168 33 their -PRON- PRP$ cord-021413-1ht1xm88 168 34 intestinal intestinal JJ cord-021413-1ht1xm88 168 35 tract tract NN cord-021413-1ht1xm88 168 36 or or CC cord-021413-1ht1xm88 168 37 for for IN cord-021413-1ht1xm88 168 38 electron electron NN cord-021413-1ht1xm88 168 39 microscopic microscopic JJ cord-021413-1ht1xm88 168 40 visualization visualization NN cord-021413-1ht1xm88 168 41 of of IN cord-021413-1ht1xm88 168 42 fecal fecal JJ cord-021413-1ht1xm88 168 43 contents content NNS cord-021413-1ht1xm88 168 44 . . . cord-021413-1ht1xm88 169 1 As as IN cord-021413-1ht1xm88 169 2 has have VBZ cord-021413-1ht1xm88 169 3 been be VBN cord-021413-1ht1xm88 169 4 shown show VBN cord-021413-1ht1xm88 169 5 experimentally experimentally RB cord-021413-1ht1xm88 169 6 , , , cord-021413-1ht1xm88 169 7 latent latent NN cord-021413-1ht1xm88 169 8 carriers carrier NNS cord-021413-1ht1xm88 169 9 can can MD cord-021413-1ht1xm88 169 10 exist exist VB cord-021413-1ht1xm88 169 11 . . . cord-021413-1ht1xm88 170 1 The the DT cord-021413-1ht1xm88 170 2 carrier carrier NN cord-021413-1ht1xm88 170 3 rate rate NN cord-021413-1ht1xm88 170 4 in in IN cord-021413-1ht1xm88 170 5 a a DT cord-021413-1ht1xm88 170 6 diarrheal diarrheal JJ cord-021413-1ht1xm88 170 7 colony colony NN cord-021413-1ht1xm88 170 8 is be VBZ cord-021413-1ht1xm88 170 9 not not RB cord-021413-1ht1xm88 170 10 known know VBN cord-021413-1ht1xm88 170 11 , , , cord-021413-1ht1xm88 170 12 nor nor CC cord-021413-1ht1xm88 170 13 is be VBZ cord-021413-1ht1xm88 170 14 the the DT cord-021413-1ht1xm88 170 15 frequency frequency NN cord-021413-1ht1xm88 170 16 of of IN cord-021413-1ht1xm88 170 17 viral viral JJ cord-021413-1ht1xm88 170 18 shedding shed VBG cord-021413-1ht1xm88 170 19 under under IN cord-021413-1ht1xm88 170 20 colony colony NN cord-021413-1ht1xm88 170 21 conditions condition NNS cord-021413-1ht1xm88 170 22 . . . cord-021413-1ht1xm88 171 1 Cheever Cheever NNP cord-021413-1ht1xm88 171 2 and and CC cord-021413-1ht1xm88 171 3 Mueller Mueller NNP cord-021413-1ht1xm88 171 4 ( ( -LRB- cord-021413-1ht1xm88 171 5 1948 1948 CD cord-021413-1ht1xm88 171 6 ) ) -RRB- cord-021413-1ht1xm88 171 7 examined examine VBD cord-021413-1ht1xm88 171 8 seasonal seasonal JJ cord-021413-1ht1xm88 171 9 variations variation NNS cord-021413-1ht1xm88 171 10 in in IN cord-021413-1ht1xm88 171 11 the the DT cord-021413-1ht1xm88 171 12 weaning weaning NN cord-021413-1ht1xm88 171 13 percentage percentage NN cord-021413-1ht1xm88 171 14 in in IN cord-021413-1ht1xm88 171 15 their -PRON- PRP$ cord-021413-1ht1xm88 171 16 mouse mouse NN cord-021413-1ht1xm88 171 17 strains strain NNS cord-021413-1ht1xm88 171 18 and and CC cord-021413-1ht1xm88 171 19 found find VBD cord-021413-1ht1xm88 171 20 that that IN cord-021413-1ht1xm88 171 21 there there EX cord-021413-1ht1xm88 171 22 was be VBD cord-021413-1ht1xm88 171 23 a a DT cord-021413-1ht1xm88 171 24 significant significant JJ cord-021413-1ht1xm88 171 25 effect effect NN cord-021413-1ht1xm88 171 26 in in IN cord-021413-1ht1xm88 171 27 only only RB cord-021413-1ht1xm88 171 28 the the DT cord-021413-1ht1xm88 171 29 CFW CFW NNP cord-021413-1ht1xm88 171 30 mice mouse NNS cord-021413-1ht1xm88 171 31 . . . cord-021413-1ht1xm88 172 1 They -PRON- PRP cord-021413-1ht1xm88 172 2 experienced experience VBD cord-021413-1ht1xm88 172 3 the the DT cord-021413-1ht1xm88 172 4 lowest low JJS cord-021413-1ht1xm88 172 5 weaning weaning NN cord-021413-1ht1xm88 172 6 rate rate NN cord-021413-1ht1xm88 172 7 in in IN cord-021413-1ht1xm88 172 8 the the DT cord-021413-1ht1xm88 172 9 late late JJ cord-021413-1ht1xm88 172 10 fall fall NN cord-021413-1ht1xm88 172 11 and and CC cord-021413-1ht1xm88 172 12 winter winter NN cord-021413-1ht1xm88 172 13 . . . cord-021413-1ht1xm88 173 1 Runner Runner NNP cord-021413-1ht1xm88 173 2 and and CC cord-021413-1ht1xm88 173 3 Palm Palm NNP cord-021413-1ht1xm88 173 4 ( ( -LRB- cord-021413-1ht1xm88 173 5 1953 1953 CD cord-021413-1ht1xm88 173 6 ) ) -RRB- cord-021413-1ht1xm88 173 7 , , , cord-021413-1ht1xm88 173 8 studying study VBG cord-021413-1ht1xm88 173 9 C3H c3h JJ cord-021413-1ht1xm88 173 10 mice mouse NNS cord-021413-1ht1xm88 173 11 , , , cord-021413-1ht1xm88 173 12 indicated indicate VBD cord-021413-1ht1xm88 173 13 that that IN cord-021413-1ht1xm88 173 14 there there EX cord-021413-1ht1xm88 173 15 was be VBD cord-021413-1ht1xm88 173 16 a a DT cord-021413-1ht1xm88 173 17 higher high JJR cord-021413-1ht1xm88 173 18 incidence incidence NN cord-021413-1ht1xm88 173 19 of of IN cord-021413-1ht1xm88 173 20 diarrhea diarrhea NN cord-021413-1ht1xm88 173 21 in in IN cord-021413-1ht1xm88 173 22 December December NNP cord-021413-1ht1xm88 173 23 / / SYM cord-021413-1ht1xm88 173 24 January January NNP cord-021413-1ht1xm88 173 25 ( ( -LRB- cord-021413-1ht1xm88 173 26 Kraft Kraft NNP cord-021413-1ht1xm88 173 27 , , , cord-021413-1ht1xm88 173 28 1961 1961 CD cord-021413-1ht1xm88 173 29 ; ; : cord-021413-1ht1xm88 173 30 Blackwell Blackwell NNP cord-021413-1ht1xm88 173 31 et et NNP cord-021413-1ht1xm88 173 32 al al NNP cord-021413-1ht1xm88 173 33 . . NNP cord-021413-1ht1xm88 173 34 , , , cord-021413-1ht1xm88 173 35 1966 1966 CD cord-021413-1ht1xm88 173 36 ) ) -RRB- cord-021413-1ht1xm88 173 37 , , , cord-021413-1ht1xm88 173 38 complement complement JJ cord-021413-1ht1xm88 173 39 fixation fixation NN cord-021413-1ht1xm88 173 40 ( ( -LRB- cord-021413-1ht1xm88 173 41 Wilsnack Wilsnack NNP cord-021413-1ht1xm88 173 42 et et NNP cord-021413-1ht1xm88 173 43 al al NNP cord-021413-1ht1xm88 173 44 . . NNP cord-021413-1ht1xm88 173 45 , , , cord-021413-1ht1xm88 173 46 1969 1969 CD cord-021413-1ht1xm88 173 47 ; ; : cord-021413-1ht1xm88 173 48 Kapikian Kapikian NNP cord-021413-1ht1xm88 173 49 et et FW cord-021413-1ht1xm88 173 50 al al NNP cord-021413-1ht1xm88 173 51 , , , cord-021413-1ht1xm88 173 52 1976 1976 CD cord-021413-1ht1xm88 173 53 ; ; : cord-021413-1ht1xm88 173 54 Thouless Thouless NNP cord-021413-1ht1xm88 173 55 et et NNP cord-021413-1ht1xm88 173 56 al al NNP cord-021413-1ht1xm88 173 57 . . NNP cord-021413-1ht1xm88 173 58 , , , cord-021413-1ht1xm88 173 59 1977b 1977b CD cord-021413-1ht1xm88 173 60 ) ) -RRB- cord-021413-1ht1xm88 173 61 , , , cord-021413-1ht1xm88 173 62 direct direct JJ cord-021413-1ht1xm88 173 63 immunofluorescent immunofluorescent NN cord-021413-1ht1xm88 173 64 staining staining NN cord-021413-1ht1xm88 173 65 or or CC cord-021413-1ht1xm88 173 66 precipitin precipitin NNP cord-021413-1ht1xm88 174 1 ( ( -LRB- cord-021413-1ht1xm88 174 2 Wilsnack Wilsnack NNP cord-021413-1ht1xm88 174 3 et et NNP cord-021413-1ht1xm88 174 4 al al NNP cord-021413-1ht1xm88 174 5 . . NNP cord-021413-1ht1xm88 174 6 , , , cord-021413-1ht1xm88 174 7 1969 1969 CD cord-021413-1ht1xm88 174 8 ; ; : cord-021413-1ht1xm88 174 9 Spence Spence NNP cord-021413-1ht1xm88 174 10 et et NNP cord-021413-1ht1xm88 174 11 al al NNP cord-021413-1ht1xm88 174 12 . . NNP cord-021413-1ht1xm88 174 13 , , , cord-021413-1ht1xm88 174 14 1975 1975 CD cord-021413-1ht1xm88 174 15 ; ; . cord-021413-1ht1xm88 175 1 Foster Foster NNP cord-021413-1ht1xm88 175 2 α/. α/. NN cord-021413-1ht1xm88 175 3 , , , cord-021413-1ht1xm88 175 4 1975 1975 CD cord-021413-1ht1xm88 175 5 ; ; : cord-021413-1ht1xm88 175 6 Peterson Peterson NNP cord-021413-1ht1xm88 175 7 α/. α/. NNP cord-021413-1ht1xm88 175 8 , , , cord-021413-1ht1xm88 175 9 1976 1976 CD cord-021413-1ht1xm88 175 10 ) ) -RRB- cord-021413-1ht1xm88 175 11 , , , cord-021413-1ht1xm88 175 12 immune immune JJ cord-021413-1ht1xm88 175 13 electron electron NN cord-021413-1ht1xm88 175 14 microscopy microscopy NN cord-021413-1ht1xm88 175 15 ( ( -LRB- cord-021413-1ht1xm88 175 16 Kapikian Kapikian NNP cord-021413-1ht1xm88 175 17 et et FW cord-021413-1ht1xm88 175 18 al al NNP cord-021413-1ht1xm88 175 19 . . NNP cord-021413-1ht1xm88 175 20 , , , cord-021413-1ht1xm88 175 21 1974 1974 CD cord-021413-1ht1xm88 175 22 ; ; : cord-021413-1ht1xm88 175 23 Bridger Bridger NNP cord-021413-1ht1xm88 175 24 and and CC cord-021413-1ht1xm88 175 25 Woode Woode NNP cord-021413-1ht1xm88 175 26 , , , cord-021413-1ht1xm88 175 27 1975 1975 CD cord-021413-1ht1xm88 175 28 ) ) -RRB- cord-021413-1ht1xm88 175 29 , , , cord-021413-1ht1xm88 175 30 immunoelectroosmophoresis immunoelectroosmophoresis NNP cord-021413-1ht1xm88 175 31 ( ( -LRB- cord-021413-1ht1xm88 175 32 Tufvesson Tufvesson NNP cord-021413-1ht1xm88 175 33 and and CC cord-021413-1ht1xm88 175 34 Johnsson Johnsson NNP cord-021413-1ht1xm88 175 35 , , , cord-021413-1ht1xm88 175 36 1976 1976 CD cord-021413-1ht1xm88 175 37 ; ; : cord-021413-1ht1xm88 175 38 Middleton Middleton NNP cord-021413-1ht1xm88 175 39 et et NNP cord-021413-1ht1xm88 175 40 al al NNP cord-021413-1ht1xm88 175 41 . . NNP cord-021413-1ht1xm88 175 42 , , , cord-021413-1ht1xm88 175 43 1976 1976 CD cord-021413-1ht1xm88 175 44 ) ) -RRB- cord-021413-1ht1xm88 176 1 , , , cord-021413-1ht1xm88 176 2 enzyme enzyme NN cord-021413-1ht1xm88 176 3 - - HYPH cord-021413-1ht1xm88 176 4 linked link VBN cord-021413-1ht1xm88 176 5 i -PRON- PRP cord-021413-1ht1xm88 176 6 m be VBP cord-021413-1ht1xm88 176 7 munosorbent munosorbent NN cord-021413-1ht1xm88 176 8 assay assay NN cord-021413-1ht1xm88 176 9 ( ( -LRB- cord-021413-1ht1xm88 176 10 ELISA ELISA NNP cord-021413-1ht1xm88 176 11 ) ) -RRB- cord-021413-1ht1xm88 176 12 ( ( -LRB- cord-021413-1ht1xm88 176 13 Scherrer Scherrer NNP cord-021413-1ht1xm88 176 14 and and CC cord-021413-1ht1xm88 176 15 Bernard Bernard NNP cord-021413-1ht1xm88 176 16 , , , cord-021413-1ht1xm88 176 17 1977 1977 CD cord-021413-1ht1xm88 176 18 ; ; : cord-021413-1ht1xm88 176 19 El El NNP cord-021413-1ht1xm88 176 20 lens lens NNP cord-021413-1ht1xm88 176 21 etal etal NNP cord-021413-1ht1xm88 176 22 . . NNP cord-021413-1ht1xm88 176 23 , , , cord-021413-1ht1xm88 176 24 1978 1978 CD cord-021413-1ht1xm88 176 25 ; ; : cord-021413-1ht1xm88 176 26 Yolken Yolken NNP cord-021413-1ht1xm88 176 27 etal etal NNP cord-021413-1ht1xm88 176 28 . . NNP cord-021413-1ht1xm88 176 29 , , , cord-021413-1ht1xm88 176 30 1978a 1978a CD cord-021413-1ht1xm88 176 31 , , , cord-021413-1ht1xm88 176 32 b b NN cord-021413-1ht1xm88 176 33 , , , cord-021413-1ht1xm88 176 34 c c NNP cord-021413-1ht1xm88 176 35 ) ) -RRB- cord-021413-1ht1xm88 176 36 , , , cord-021413-1ht1xm88 176 37 radioimmunoas radioimmunoas NN cord-021413-1ht1xm88 176 38 say say VBP cord-021413-1ht1xm88 176 39 ( ( -LRB- cord-021413-1ht1xm88 176 40 Acres Acres NNP cord-021413-1ht1xm88 176 41 and and CC cord-021413-1ht1xm88 176 42 Babiuk Babiuk NNP cord-021413-1ht1xm88 176 43 , , , cord-021413-1ht1xm88 176 44 1978 1978 CD cord-021413-1ht1xm88 176 45 ; ; : cord-021413-1ht1xm88 176 46 Kalica Kalica NNP cord-021413-1ht1xm88 176 47 et et NNP cord-021413-1ht1xm88 176 48 al al NNP cord-021413-1ht1xm88 176 49 . . NNP cord-021413-1ht1xm88 176 50 , , , cord-021413-1ht1xm88 176 51 1977 1977 CD cord-021413-1ht1xm88 176 52 ; ; : cord-021413-1ht1xm88 176 53 Middleton Middleton NNP cord-021413-1ht1xm88 176 54 et et NNP cord-021413-1ht1xm88 176 55 al al NNP cord-021413-1ht1xm88 176 56 . . NNP cord-021413-1ht1xm88 176 57 , , , cord-021413-1ht1xm88 176 58 1977 1977 CD cord-021413-1ht1xm88 176 59 ) ) -RRB- cord-021413-1ht1xm88 176 60 , , , cord-021413-1ht1xm88 176 61 immunodiffusion immunodiffusion NN cord-021413-1ht1xm88 176 62 ( ( -LRB- cord-021413-1ht1xm88 176 63 Woode Woode NNP cord-021413-1ht1xm88 176 64 et et FW cord-021413-1ht1xm88 176 65 al al NNP cord-021413-1ht1xm88 176 66 . . NNP cord-021413-1ht1xm88 176 67 , , , cord-021413-1ht1xm88 176 68 1976 1976 CD cord-021413-1ht1xm88 176 69 ) ) -RRB- cord-021413-1ht1xm88 176 70 , , , cord-021413-1ht1xm88 176 71 hemagglutination hemagglutination NN cord-021413-1ht1xm88 176 72 inhibition inhibition NN cord-021413-1ht1xm88 176 73 ( ( -LRB- cord-021413-1ht1xm88 176 74 Fauvel Fauvel NNP cord-021413-1ht1xm88 176 75 et et FW cord-021413-1ht1xm88 176 76 al al NNP cord-021413-1ht1xm88 176 77 . . NNP cord-021413-1ht1xm88 176 78 , , , cord-021413-1ht1xm88 176 79 1978 1978 CD cord-021413-1ht1xm88 176 80 ) ) -RRB- cord-021413-1ht1xm88 176 81 , , , cord-021413-1ht1xm88 176 82 enzymelinked enzymelinked JJ cord-021413-1ht1xm88 176 83 fluorescence fluorescence NN cord-021413-1ht1xm88 176 84 assay assay NN cord-021413-1ht1xm88 176 85 ( ( -LRB- cord-021413-1ht1xm88 176 86 ELISA ELISA NNP cord-021413-1ht1xm88 176 87 ) ) -RRB- cord-021413-1ht1xm88 176 88 ( ( -LRB- cord-021413-1ht1xm88 176 89 Yolken Yolken NNP cord-021413-1ht1xm88 176 90 and and CC cord-021413-1ht1xm88 176 91 Stopa Stopa NNP cord-021413-1ht1xm88 176 92 , , , cord-021413-1ht1xm88 176 93 1979 1979 CD cord-021413-1ht1xm88 176 94 ) ) -RRB- cord-021413-1ht1xm88 176 95 , , , cord-021413-1ht1xm88 176 96 an an DT cord-021413-1ht1xm88 176 97 unlabeled unlabeled JJ cord-021413-1ht1xm88 176 98 soluble soluble JJ cord-021413-1ht1xm88 176 99 enzyme enzyme NN cord-021413-1ht1xm88 176 100 peroxidase peroxidase NN cord-021413-1ht1xm88 176 101 - - HYPH cord-021413-1ht1xm88 176 102 antiperoxidase antiperoxidase NN cord-021413-1ht1xm88 176 103 method method NN cord-021413-1ht1xm88 176 104 , , , cord-021413-1ht1xm88 176 105 plaque plaque NN cord-021413-1ht1xm88 176 106 reduction reduction NN cord-021413-1ht1xm88 176 107 test test NN cord-021413-1ht1xm88 176 108 ( ( -LRB- cord-021413-1ht1xm88 176 109 Estes Estes NNP cord-021413-1ht1xm88 176 110 and and CC cord-021413-1ht1xm88 176 111 Graham Graham NNP cord-021413-1ht1xm88 176 112 , , , cord-021413-1ht1xm88 176 113 1980 1980 CD cord-021413-1ht1xm88 176 114 ) ) -RRB- cord-021413-1ht1xm88 176 115 , , , cord-021413-1ht1xm88 176 116 serologic serologic NN cord-021413-1ht1xm88 176 117 trapping trap VBG cord-021413-1ht1xm88 176 118 on on IN cord-021413-1ht1xm88 176 119 antibody antibody NN cord-021413-1ht1xm88 176 120 - - HYPH cord-021413-1ht1xm88 176 121 coated coat VBN cord-021413-1ht1xm88 176 122 electron electron NN cord-021413-1ht1xm88 176 123 microscope microscope NN cord-021413-1ht1xm88 176 124 grids grid NNS cord-021413-1ht1xm88 177 1 ( ( -LRB- cord-021413-1ht1xm88 177 2 Nicolaieff Nicolaieff NNP cord-021413-1ht1xm88 177 3 et et NNP cord-021413-1ht1xm88 177 4 al al NNP cord-021413-1ht1xm88 177 5 . . NNP cord-021413-1ht1xm88 177 6 , , , cord-021413-1ht1xm88 177 7 1980 1980 CD cord-021413-1ht1xm88 177 8 ) ) -RRB- cord-021413-1ht1xm88 177 9 , , , cord-021413-1ht1xm88 177 10 a a DT cord-021413-1ht1xm88 177 11 solid solid JJ cord-021413-1ht1xm88 177 12 phase phase NN cord-021413-1ht1xm88 177 13 system system NN cord-021413-1ht1xm88 177 14 ( ( -LRB- cord-021413-1ht1xm88 177 15 SPACE space NN cord-021413-1ht1xm88 177 16 , , , cord-021413-1ht1xm88 177 17 solid solid JJ cord-021413-1ht1xm88 177 18 phase phase NN cord-021413-1ht1xm88 177 19 aggregation aggregation NN cord-021413-1ht1xm88 177 20 of of IN cord-021413-1ht1xm88 177 21 coupled coupled JJ cord-021413-1ht1xm88 177 22 erythrocytes erythrocyte NNS cord-021413-1ht1xm88 177 23 ) ) -RRB- cord-021413-1ht1xm88 177 24 for for IN cord-021413-1ht1xm88 177 25 detection detection NN cord-021413-1ht1xm88 177 26 of of IN cord-021413-1ht1xm88 177 27 rotaviruses rotavirus NNS cord-021413-1ht1xm88 177 28 in in IN cord-021413-1ht1xm88 177 29 feces fece NNS cord-021413-1ht1xm88 178 1 ( ( -LRB- cord-021413-1ht1xm88 178 2 Bradbume Bradbume NNP cord-021413-1ht1xm88 178 3 et et FW cord-021413-1ht1xm88 178 4 al al NNP cord-021413-1ht1xm88 178 5 . . NNP cord-021413-1ht1xm88 178 6 , , , cord-021413-1ht1xm88 178 7 1979 1979 CD cord-021413-1ht1xm88 178 8 ) ) -RRB- cord-021413-1ht1xm88 178 9 , , , cord-021413-1ht1xm88 178 10 and and CC cord-021413-1ht1xm88 178 11 immune immune JJ cord-021413-1ht1xm88 178 12 electron electron NN cord-021413-1ht1xm88 178 13 microscopy microscopy NN cord-021413-1ht1xm88 178 14 with with IN cord-021413-1ht1xm88 178 15 serum serum NN cord-021413-1ht1xm88 178 16 in in IN cord-021413-1ht1xm88 178 17 agar agar NNP cord-021413-1ht1xm88 178 18 diffusion diffusion NN cord-021413-1ht1xm88 179 1 ( ( -LRB- cord-021413-1ht1xm88 179 2 Lamontagne Lamontagne NNP cord-021413-1ht1xm88 179 3 et et FW cord-021413-1ht1xm88 179 4 al al NNP cord-021413-1ht1xm88 179 5 . . NNP cord-021413-1ht1xm88 179 6 , , , cord-021413-1ht1xm88 179 7 1980 1980 CD cord-021413-1ht1xm88 179 8 ) ) -RRB- cord-021413-1ht1xm88 179 9 . . . cord-021413-1ht1xm88 180 1 More more RBR cord-021413-1ht1xm88 180 2 recently recently RB cord-021413-1ht1xm88 180 3 , , , cord-021413-1ht1xm88 180 4 Sheridan Sheridan NNP cord-021413-1ht1xm88 180 5 and and CC cord-021413-1ht1xm88 180 6 Aurelian Aurelian NNP cord-021413-1ht1xm88 180 7 ( ( -LRB- cord-021413-1ht1xm88 180 8 1981 1981 CD cord-021413-1ht1xm88 180 9 ) ) -RRB- cord-021413-1ht1xm88 180 10 have have VBP cord-021413-1ht1xm88 180 11 described describe VBN cord-021413-1ht1xm88 180 12 an an DT cord-021413-1ht1xm88 180 13 ELISA ELISA NNP cord-021413-1ht1xm88 180 14 test test NN cord-021413-1ht1xm88 180 15 for for IN cord-021413-1ht1xm88 180 16 EDIM EDIM NNP cord-021413-1ht1xm88 180 17 virus virus NN cord-021413-1ht1xm88 180 18 which which WDT cord-021413-1ht1xm88 180 19 should should MD cord-021413-1ht1xm88 180 20 prove prove VB cord-021413-1ht1xm88 180 21 beneficial beneficial JJ cord-021413-1ht1xm88 180 22 for for IN cord-021413-1ht1xm88 180 23 both both DT cord-021413-1ht1xm88 180 24 practical practical JJ cord-021413-1ht1xm88 180 25 ( ( -LRB- cord-021413-1ht1xm88 180 26 serologic serologic NNP cord-021413-1ht1xm88 180 27 ) ) -RRB- cord-021413-1ht1xm88 180 28 purposes purpose NNS cord-021413-1ht1xm88 180 29 and and CC cord-021413-1ht1xm88 180 30 for for IN cord-021413-1ht1xm88 180 31 investigations investigation NNS cord-021413-1ht1xm88 180 32 of of IN cord-021413-1ht1xm88 180 33 the the DT cord-021413-1ht1xm88 180 34 antigenic antigenic JJ cord-021413-1ht1xm88 180 35 structure structure NN cord-021413-1ht1xm88 180 36 of of IN cord-021413-1ht1xm88 180 37 the the DT cord-021413-1ht1xm88 180 38 virion virion NN cord-021413-1ht1xm88 180 39 . . . cord-021413-1ht1xm88 181 1 In in IN cord-021413-1ht1xm88 181 2 the the DT cord-021413-1ht1xm88 181 3 absence absence NN cord-021413-1ht1xm88 181 4 of of IN cord-021413-1ht1xm88 181 5 a a DT cord-021413-1ht1xm88 181 6 reliable reliable JJ cord-021413-1ht1xm88 181 7 tissue tissue NN cord-021413-1ht1xm88 181 8 culture culture NN cord-021413-1ht1xm88 181 9 system system NN cord-021413-1ht1xm88 181 10 , , , cord-021413-1ht1xm88 181 11 EDIM edim NN cord-021413-1ht1xm88 181 12 virus virus NN cord-021413-1ht1xm88 181 13 isolation isolation NN cord-021413-1ht1xm88 181 14 is be VBZ cord-021413-1ht1xm88 181 15 generally generally RB cord-021413-1ht1xm88 181 16 impractical impractical JJ cord-021413-1ht1xm88 181 17 . . . cord-021413-1ht1xm88 182 1 Bacteria Bacteria NNS cord-021413-1ht1xm88 182 2 - - HYPH cord-021413-1ht1xm88 182 3 free free JJ cord-021413-1ht1xm88 182 4 filtrates filtrate NNS cord-021413-1ht1xm88 182 5 of of IN cord-021413-1ht1xm88 182 6 intestinal intestinal JJ cord-021413-1ht1xm88 182 7 suspensions suspension NNS cord-021413-1ht1xm88 182 8 can can MD cord-021413-1ht1xm88 182 9 , , , cord-021413-1ht1xm88 182 10 of of IN cord-021413-1ht1xm88 182 11 course course NN cord-021413-1ht1xm88 182 12 , , , cord-021413-1ht1xm88 182 13 be be VB cord-021413-1ht1xm88 182 14 given give VBN cord-021413-1ht1xm88 182 15 to to IN cord-021413-1ht1xm88 182 16 diarrheafree diarrheafree JJ cord-021413-1ht1xm88 182 17 animals animal NNS cord-021413-1ht1xm88 182 18 ( ( -LRB- cord-021413-1ht1xm88 182 19 gnotobiotes gnotobiotes NNP cord-021413-1ht1xm88 182 20 or or CC cord-021413-1ht1xm88 182 21 axenics axenics NNP cord-021413-1ht1xm88 182 22 ) ) -RRB- cord-021413-1ht1xm88 182 23 , , , cord-021413-1ht1xm88 182 24 but but CC cord-021413-1ht1xm88 182 25 this this DT cord-021413-1ht1xm88 182 26 is be VBZ cord-021413-1ht1xm88 182 27 expensive expensive JJ cord-021413-1ht1xm88 182 28 and and CC cord-021413-1ht1xm88 182 29 inefficient inefficient JJ cord-021413-1ht1xm88 182 30 . . . cord-021413-1ht1xm88 183 1 On on IN cord-021413-1ht1xm88 183 2 the the DT cord-021413-1ht1xm88 183 3 other other JJ cord-021413-1ht1xm88 183 4 hand hand NN cord-021413-1ht1xm88 183 5 , , , cord-021413-1ht1xm88 183 6 such such JJ cord-021413-1ht1xm88 183 7 filtrates filtrate NNS cord-021413-1ht1xm88 183 8 may may MD cord-021413-1ht1xm88 183 9 be be VB cord-021413-1ht1xm88 183 10 concen concen NNP cord-021413-1ht1xm88 183 11 trated trate VBN cord-021413-1ht1xm88 183 12 by by IN cord-021413-1ht1xm88 183 13 ultracentrifugation ultracentrifugation NN cord-021413-1ht1xm88 183 14 and and CC cord-021413-1ht1xm88 183 15 examined examine VBD cord-021413-1ht1xm88 183 16 in in IN cord-021413-1ht1xm88 183 17 the the DT cord-021413-1ht1xm88 183 18 electron electron NN cord-021413-1ht1xm88 183 19 mi mi IN cord-021413-1ht1xm88 183 20 croscope croscope NN cord-021413-1ht1xm88 183 21 for for IN cord-021413-1ht1xm88 183 22 characteristic characteristic JJ cord-021413-1ht1xm88 183 23 virus virus NN cord-021413-1ht1xm88 183 24 particles particle NNS cord-021413-1ht1xm88 183 25 Flewett Flewett NNP cord-021413-1ht1xm88 183 26 , , , cord-021413-1ht1xm88 183 27 1978 1978 CD cord-021413-1ht1xm88 183 28 ) ) -RRB- cord-021413-1ht1xm88 183 29 . . . cord-021413-1ht1xm88 184 1 The the DT cord-021413-1ht1xm88 184 2 particles particle NNS cord-021413-1ht1xm88 184 3 may may MD cord-021413-1ht1xm88 184 4 also also RB cord-021413-1ht1xm88 184 5 be be VB cord-021413-1ht1xm88 184 6 identified identify VBN cord-021413-1ht1xm88 184 7 by by IN cord-021413-1ht1xm88 184 8 immune immune JJ cord-021413-1ht1xm88 184 9 electron electron NN cord-021413-1ht1xm88 184 10 microscopy microscopy NN cord-021413-1ht1xm88 184 11 . . . cord-021413-1ht1xm88 185 1 A a DT cord-021413-1ht1xm88 185 2 practical practical JJ cord-021413-1ht1xm88 185 3 approach approach NN cord-021413-1ht1xm88 185 4 to to IN cord-021413-1ht1xm88 185 5 a a DT cord-021413-1ht1xm88 185 6 presumptive presumptive JJ cord-021413-1ht1xm88 185 7 diagnosis diagnosis NN cord-021413-1ht1xm88 185 8 would would MD cord-021413-1ht1xm88 185 9 be be VB cord-021413-1ht1xm88 185 10 to to TO cord-021413-1ht1xm88 185 11 kill kill VB cord-021413-1ht1xm88 185 12 selected select VBN cord-021413-1ht1xm88 185 13 animals animal NNS cord-021413-1ht1xm88 185 14 in in IN cord-021413-1ht1xm88 185 15 order order NN cord-021413-1ht1xm88 185 16 to to TO cord-021413-1ht1xm88 185 17 examine examine VB cord-021413-1ht1xm88 185 18 the the DT cord-021413-1ht1xm88 185 19 appearance appearance NN cord-021413-1ht1xm88 185 20 of of IN cord-021413-1ht1xm88 185 21 the the DT cord-021413-1ht1xm88 185 22 colonic colonic JJ cord-021413-1ht1xm88 185 23 contents content NNS cord-021413-1ht1xm88 185 24 . . . cord-021413-1ht1xm88 186 1 The the DT cord-021413-1ht1xm88 186 2 inclusion inclusion NN cord-021413-1ht1xm88 186 3 of of IN cord-021413-1ht1xm88 186 4 sentinel sentinel JJ cord-021413-1ht1xm88 186 5 dams dam NNS cord-021413-1ht1xm88 186 6 with with IN cord-021413-1ht1xm88 186 7 litters litter NNS cord-021413-1ht1xm88 186 8 in in IN cord-021413-1ht1xm88 186 9 a a DT cord-021413-1ht1xm88 186 10 breeding breeding NN cord-021413-1ht1xm88 186 11 colony colony NN cord-021413-1ht1xm88 186 12 should should MD cord-021413-1ht1xm88 186 13 be be VB cord-021413-1ht1xm88 186 14 considered consider VBN cord-021413-1ht1xm88 186 15 . . . cord-021413-1ht1xm88 187 1 These these DT cord-021413-1ht1xm88 187 2 might may MD cord-021413-1ht1xm88 187 3 be be VB cord-021413-1ht1xm88 187 4 sac sac NN cord-021413-1ht1xm88 187 5 rificed rifice VBN cord-021413-1ht1xm88 187 6 at at IN cord-021413-1ht1xm88 187 7 intervals interval NNS cord-021413-1ht1xm88 187 8 to to TO cord-021413-1ht1xm88 187 9 determine determine VB cord-021413-1ht1xm88 187 10 the the DT cord-021413-1ht1xm88 187 11 presence presence NN cord-021413-1ht1xm88 187 12 of of IN cord-021413-1ht1xm88 187 13 EDIM EDIM NNP cord-021413-1ht1xm88 187 14 in in IN cord-021413-1ht1xm88 187 15 the the DT cord-021413-1ht1xm88 187 16 colony colony NN cord-021413-1ht1xm88 187 17 . . . cord-021413-1ht1xm88 188 1 Together together RB cord-021413-1ht1xm88 188 2 with with IN cord-021413-1ht1xm88 188 3 the the DT cord-021413-1ht1xm88 188 4 clinical clinical JJ cord-021413-1ht1xm88 188 5 history history NN cord-021413-1ht1xm88 188 6 of of IN cord-021413-1ht1xm88 188 7 the the DT cord-021413-1ht1xm88 188 8 mouse mouse NN cord-021413-1ht1xm88 188 9 colony colony NN cord-021413-1ht1xm88 188 10 , , , cord-021413-1ht1xm88 188 11 this this DT cord-021413-1ht1xm88 188 12 practice practice NN cord-021413-1ht1xm88 188 13 may may MD cord-021413-1ht1xm88 188 14 provide provide VB cord-021413-1ht1xm88 188 15 a a DT cord-021413-1ht1xm88 188 16 fairly fairly RB cord-021413-1ht1xm88 188 17 reliable reliable JJ cord-021413-1ht1xm88 188 18 , , , cord-021413-1ht1xm88 188 19 although although IN cord-021413-1ht1xm88 188 20 not not RB cord-021413-1ht1xm88 188 21 pathognomonic pathognomonic JJ cord-021413-1ht1xm88 188 22 , , , cord-021413-1ht1xm88 188 23 indication indication NN cord-021413-1ht1xm88 188 24 of of IN cord-021413-1ht1xm88 188 25 the the DT cord-021413-1ht1xm88 188 26 presence presence NN cord-021413-1ht1xm88 188 27 of of IN cord-021413-1ht1xm88 188 28 EDIM EDIM NNP cord-021413-1ht1xm88 188 29 . . . cord-021413-1ht1xm88 189 1 His -PRON- PRP$ cord-021413-1ht1xm88 189 2 topathologic topathologic JJ cord-021413-1ht1xm88 189 3 examination examination NN cord-021413-1ht1xm88 189 4 could could MD cord-021413-1ht1xm88 189 5 also also RB cord-021413-1ht1xm88 189 6 be be VB cord-021413-1ht1xm88 189 7 of of IN cord-021413-1ht1xm88 189 8 value value NN cord-021413-1ht1xm88 189 9 . . . cord-021413-1ht1xm88 190 1 Based base VBN cord-021413-1ht1xm88 190 2 on on IN cord-021413-1ht1xm88 190 3 experimental experimental JJ cord-021413-1ht1xm88 190 4 results result NNS cord-021413-1ht1xm88 190 5 , , , cord-021413-1ht1xm88 190 6 Kraft Kraft NNP cord-021413-1ht1xm88 190 7 et et NNP cord-021413-1ht1xm88 190 8 al al NNP cord-021413-1ht1xm88 190 9 . . . cord-021413-1ht1xm88 191 1 ( ( -LRB- cord-021413-1ht1xm88 191 2 1964 1964 CD cord-021413-1ht1xm88 191 3 ) ) -RRB- cord-021413-1ht1xm88 191 4 proposed propose VBD cord-021413-1ht1xm88 191 5 the the DT cord-021413-1ht1xm88 191 6 use use NN cord-021413-1ht1xm88 191 7 of of IN cord-021413-1ht1xm88 191 8 air air NN cord-021413-1ht1xm88 191 9 - - HYPH cord-021413-1ht1xm88 191 10 filter filter NN cord-021413-1ht1xm88 191 11 devices device NNS cord-021413-1ht1xm88 191 12 , , , cord-021413-1ht1xm88 191 13 essentially essentially RB cord-021413-1ht1xm88 191 14 dust dust NN cord-021413-1ht1xm88 191 15 caps cap NNS cord-021413-1ht1xm88 191 16 for for IN cord-021413-1ht1xm88 191 17 each each DT cord-021413-1ht1xm88 191 18 cage cage NN cord-021413-1ht1xm88 191 19 , , , cord-021413-1ht1xm88 191 20 for for IN cord-021413-1ht1xm88 191 21 the the DT cord-021413-1ht1xm88 191 22 practical practical JJ cord-021413-1ht1xm88 191 23 control control NN cord-021413-1ht1xm88 191 24 of of IN cord-021413-1ht1xm88 191 25 airborne airborne JJ cord-021413-1ht1xm88 191 26 transmission transmission NN cord-021413-1ht1xm88 191 27 of of IN cord-021413-1ht1xm88 191 28 EDIM EDIM NNP cord-021413-1ht1xm88 191 29 in in IN cord-021413-1ht1xm88 191 30 a a DT cord-021413-1ht1xm88 191 31 commercial commercial JJ cord-021413-1ht1xm88 191 32 mouse mouse NN cord-021413-1ht1xm88 191 33 colony colony NN cord-021413-1ht1xm88 191 34 . . . cord-021413-1ht1xm88 192 1 It -PRON- PRP cord-021413-1ht1xm88 192 2 was be VBD cord-021413-1ht1xm88 192 3 subsequently subsequently RB cord-021413-1ht1xm88 192 4 shown show VBN cord-021413-1ht1xm88 192 5 ( ( -LRB- cord-021413-1ht1xm88 192 6 Kraft Kraft NNP cord-021413-1ht1xm88 192 7 , , , cord-021413-1ht1xm88 192 8 1966 1966 CD cord-021413-1ht1xm88 192 9 ) ) -RRB- cord-021413-1ht1xm88 192 10 that that IN cord-021413-1ht1xm88 192 11 43 43 CD cord-021413-1ht1xm88 192 12 % % NN cord-021413-1ht1xm88 192 13 of of IN cord-021413-1ht1xm88 192 14 first first JJ cord-021413-1ht1xm88 192 15 litters litter NNS cord-021413-1ht1xm88 192 16 and and CC cord-021413-1ht1xm88 192 17 79 79 CD cord-021413-1ht1xm88 192 18 % % NN cord-021413-1ht1xm88 192 19 of of IN cord-021413-1ht1xm88 192 20 all all DT cord-021413-1ht1xm88 192 21 other other JJ cord-021413-1ht1xm88 192 22 litter litter NN cord-021413-1ht1xm88 192 23 parities parity NNS cord-021413-1ht1xm88 192 24 were be VBD cord-021413-1ht1xm88 192 25 weaned wean VBN cord-021413-1ht1xm88 192 26 from from IN cord-021413-1ht1xm88 192 27 cages cage NNS cord-021413-1ht1xm88 192 28 without without IN cord-021413-1ht1xm88 192 29 filters filter NNS cord-021413-1ht1xm88 192 30 , , , cord-021413-1ht1xm88 192 31 whereas whereas IN cord-021413-1ht1xm88 192 32 in in IN cord-021413-1ht1xm88 192 33 cages cage NNS cord-021413-1ht1xm88 192 34 pro pro JJ cord-021413-1ht1xm88 192 35 vided vide VBN cord-021413-1ht1xm88 192 36 with with IN cord-021413-1ht1xm88 192 37 filters filter NNS cord-021413-1ht1xm88 192 38 , , , cord-021413-1ht1xm88 192 39 weaning wean VBG cord-021413-1ht1xm88 192 40 percentages percentage NNS cord-021413-1ht1xm88 192 41 were be VBD cord-021413-1ht1xm88 192 42 96 96 CD cord-021413-1ht1xm88 192 43 and and CC cord-021413-1ht1xm88 192 44 99 99 CD cord-021413-1ht1xm88 192 45 % % NN cord-021413-1ht1xm88 192 46 , , , cord-021413-1ht1xm88 192 47 respectively respectively RB cord-021413-1ht1xm88 192 48 , , , cord-021413-1ht1xm88 192 49 during during IN cord-021413-1ht1xm88 192 50 the the DT cord-021413-1ht1xm88 192 51 same same JJ cord-021413-1ht1xm88 192 52 observation observation NN cord-021413-1ht1xm88 192 53 period period NN cord-021413-1ht1xm88 192 54 . . . cord-021413-1ht1xm88 193 1 It -PRON- PRP cord-021413-1ht1xm88 193 2 should should MD cord-021413-1ht1xm88 193 3 be be VB cord-021413-1ht1xm88 193 4 pointed point VBN cord-021413-1ht1xm88 193 5 out out RP cord-021413-1ht1xm88 193 6 that that IN cord-021413-1ht1xm88 193 7 both both CC cord-021413-1ht1xm88 193 8 EDIM EDIM NNS cord-021413-1ht1xm88 193 9 and and CC cord-021413-1ht1xm88 193 10 mouse mouse NN cord-021413-1ht1xm88 193 11 hepatitis hepatitis NN cord-021413-1ht1xm88 193 12 virus virus NN cord-021413-1ht1xm88 193 13 ( ( -LRB- cord-021413-1ht1xm88 193 14 LIVIM LIVIM NNP cord-021413-1ht1xm88 193 15 ) ) -RRB- cord-021413-1ht1xm88 193 16 were be VBD cord-021413-1ht1xm88 193 17 present present JJ cord-021413-1ht1xm88 193 18 simultaneously simultaneously RB cord-021413-1ht1xm88 193 19 in in IN cord-021413-1ht1xm88 193 20 that that DT cord-021413-1ht1xm88 193 21 colony colony NN cord-021413-1ht1xm88 193 22 . . . cord-021413-1ht1xm88 194 1 Although although IN cord-021413-1ht1xm88 194 2 the the DT cord-021413-1ht1xm88 194 3 filter filter NN cord-021413-1ht1xm88 194 4 devices device NNS cord-021413-1ht1xm88 194 5 did do VBD cord-021413-1ht1xm88 194 6 not not RB cord-021413-1ht1xm88 194 7 eliminate eliminate VB cord-021413-1ht1xm88 194 8 the the DT cord-021413-1ht1xm88 194 9 disease(s disease(s NNP cord-021413-1ht1xm88 194 10 ) ) -RRB- cord-021413-1ht1xm88 194 11 , , , cord-021413-1ht1xm88 194 12 they -PRON- PRP cord-021413-1ht1xm88 194 13 probably probably RB cord-021413-1ht1xm88 194 14 reduced reduce VBD cord-021413-1ht1xm88 194 15 the the DT cord-021413-1ht1xm88 194 16 pathogenic pathogenic JJ cord-021413-1ht1xm88 194 17 microbial microbial JJ cord-021413-1ht1xm88 194 18 load load NN cord-021413-1ht1xm88 194 19 in in IN cord-021413-1ht1xm88 194 20 the the DT cord-021413-1ht1xm88 194 21 immediate immediate JJ cord-021413-1ht1xm88 194 22 environment environment NN cord-021413-1ht1xm88 194 23 of of IN cord-021413-1ht1xm88 194 24 the the DT cord-021413-1ht1xm88 194 25 susceptible susceptible JJ cord-021413-1ht1xm88 194 26 animals animal NNS cord-021413-1ht1xm88 194 27 , , , cord-021413-1ht1xm88 194 28 but but CC cord-021413-1ht1xm88 194 29 the the DT cord-021413-1ht1xm88 194 30 precise precise JJ cord-021413-1ht1xm88 194 31 mechanism mechanism NN cord-021413-1ht1xm88 194 32 by by IN cord-021413-1ht1xm88 194 33 which which WDT cord-021413-1ht1xm88 194 34 this this DT cord-021413-1ht1xm88 194 35 control control NN cord-021413-1ht1xm88 194 36 method method NN cord-021413-1ht1xm88 194 37 succeeds succeed VBZ cord-021413-1ht1xm88 194 38 to to IN cord-021413-1ht1xm88 194 39 the the DT cord-021413-1ht1xm88 194 40 extent extent NN cord-021413-1ht1xm88 194 41 that that IN cord-021413-1ht1xm88 194 42 it -PRON- PRP cord-021413-1ht1xm88 194 43 does do VBZ cord-021413-1ht1xm88 194 44 is be VBZ cord-021413-1ht1xm88 194 45 obscure obscure JJ cord-021413-1ht1xm88 194 46 . . . cord-021413-1ht1xm88 195 1 Since since IN cord-021413-1ht1xm88 195 2 that that DT cord-021413-1ht1xm88 195 3 time time NN cord-021413-1ht1xm88 195 4 ( ( -LRB- cord-021413-1ht1xm88 195 5 1964 1964 CD cord-021413-1ht1xm88 195 6 ) ) -RRB- cord-021413-1ht1xm88 195 7 , , , cord-021413-1ht1xm88 195 8 various various JJ cord-021413-1ht1xm88 195 9 devices device NNS cord-021413-1ht1xm88 195 10 based base VBN cord-021413-1ht1xm88 195 11 on on IN cord-021413-1ht1xm88 195 12 a a DT cord-021413-1ht1xm88 195 13 filter filter NN cord-021413-1ht1xm88 195 14 cage cage NN cord-021413-1ht1xm88 195 15 or or CC cord-021413-1ht1xm88 195 16 filter filter NN cord-021413-1ht1xm88 195 17 - - HYPH cord-021413-1ht1xm88 195 18 top top NN cord-021413-1ht1xm88 195 19 design design NN cord-021413-1ht1xm88 195 20 have have VBP cord-021413-1ht1xm88 195 21 been be VBN cord-021413-1ht1xm88 195 22 utilized utilize VBN cord-021413-1ht1xm88 195 23 . . . cord-021413-1ht1xm88 196 1 Some some DT cord-021413-1ht1xm88 196 2 of of IN cord-021413-1ht1xm88 196 3 these these DT cord-021413-1ht1xm88 196 4 are be VBP cord-021413-1ht1xm88 196 5 de de FW cord-021413-1ht1xm88 196 6 scribed scribe VBN cord-021413-1ht1xm88 196 7 by by IN cord-021413-1ht1xm88 196 8 Simmons Simmons NNP cord-021413-1ht1xm88 196 9 and and CC cord-021413-1ht1xm88 196 10 Brick Brick NNP cord-021413-1ht1xm88 196 11 ( ( -LRB- cord-021413-1ht1xm88 196 12 1970 1970 CD cord-021413-1ht1xm88 196 13 ) ) -RRB- cord-021413-1ht1xm88 196 14 . . . cord-021413-1ht1xm88 197 1 Woods Woods NNP cord-021413-1ht1xm88 197 2 et et NNP cord-021413-1ht1xm88 197 3 al al NNP cord-021413-1ht1xm88 197 4 . . . cord-021413-1ht1xm88 198 1 ( ( -LRB- cord-021413-1ht1xm88 198 2 1974 1974 CD cord-021413-1ht1xm88 198 3 ) ) -RRB- cord-021413-1ht1xm88 198 4 evaluated evaluate VBD cord-021413-1ht1xm88 198 5 them -PRON- PRP cord-021413-1ht1xm88 198 6 from from IN cord-021413-1ht1xm88 198 7 the the DT cord-021413-1ht1xm88 198 8 viewpoint viewpoint NN cord-021413-1ht1xm88 198 9 of of IN cord-021413-1ht1xm88 198 10 environmental environmental JJ cord-021413-1ht1xm88 198 11 factors factor NNS cord-021413-1ht1xm88 198 12 within within IN cord-021413-1ht1xm88 198 13 the the DT cord-021413-1ht1xm88 198 14 cages cage NNS cord-021413-1ht1xm88 198 15 . . . cord-021413-1ht1xm88 199 1 They -PRON- PRP cord-021413-1ht1xm88 199 2 found find VBD cord-021413-1ht1xm88 199 3 that that IN cord-021413-1ht1xm88 199 4 dry dry JJ cord-021413-1ht1xm88 199 5 bulb bulb NN cord-021413-1ht1xm88 199 6 temperature temperature NN cord-021413-1ht1xm88 199 7 dif dif NN cord-021413-1ht1xm88 199 8 ferentials ferential NNS cord-021413-1ht1xm88 199 9 , , , cord-021413-1ht1xm88 199 10 comparing compare VBG cord-021413-1ht1xm88 199 11 environments environment NNS cord-021413-1ht1xm88 199 12 inside inside IN cord-021413-1ht1xm88 199 13 and and CC cord-021413-1ht1xm88 199 14 outside outside IN cord-021413-1ht1xm88 199 15 the the DT cord-021413-1ht1xm88 199 16 cage cage NN cord-021413-1ht1xm88 199 17 , , , cord-021413-1ht1xm88 199 18 were be VBD cord-021413-1ht1xm88 199 19 not not RB cord-021413-1ht1xm88 199 20 significantly significantly RB cord-021413-1ht1xm88 199 21 different different JJ cord-021413-1ht1xm88 199 22 ( ( -LRB- cord-021413-1ht1xm88 199 23 about about RB cord-021413-1ht1xm88 199 24 2 2 CD cord-021413-1ht1xm88 199 25 ° ° NN cord-021413-1ht1xm88 199 26 C c NN cord-021413-1ht1xm88 199 27 ) ) -RRB- cord-021413-1ht1xm88 199 28 between between IN cord-021413-1ht1xm88 199 29 fil fil NNP cord-021413-1ht1xm88 199 30 tered tere VBN cord-021413-1ht1xm88 199 31 and and CC cord-021413-1ht1xm88 199 32 unfiltered unfiltered JJ cord-021413-1ht1xm88 199 33 cages cage NNS cord-021413-1ht1xm88 199 34 , , , cord-021413-1ht1xm88 199 35 but but CC cord-021413-1ht1xm88 199 36 that that DT cord-021413-1ht1xm88 199 37 dew dew NN cord-021413-1ht1xm88 199 38 point point NN cord-021413-1ht1xm88 199 39 differentials differential NNS cord-021413-1ht1xm88 199 40 were be VBD cord-021413-1ht1xm88 199 41 significantly significantly RB cord-021413-1ht1xm88 199 42 greater great JJR cord-021413-1ht1xm88 199 43 in in IN cord-021413-1ht1xm88 199 44 the the DT cord-021413-1ht1xm88 199 45 filtered filter VBN cord-021413-1ht1xm88 199 46 cages cage NNS cord-021413-1ht1xm88 199 47 ( ( -LRB- cord-021413-1ht1xm88 199 48 about about RB cord-021413-1ht1xm88 199 49 5 5 CD cord-021413-1ht1xm88 199 50 ° ° NN cord-021413-1ht1xm88 199 51 C c NN cord-021413-1ht1xm88 199 52 ) ) -RRB- cord-021413-1ht1xm88 199 53 than than IN cord-021413-1ht1xm88 199 54 in in IN cord-021413-1ht1xm88 199 55 unfiltered unfiltered JJ cord-021413-1ht1xm88 199 56 cages cage NNS cord-021413-1ht1xm88 199 57 ( ( -LRB- cord-021413-1ht1xm88 199 58 about about RB cord-021413-1ht1xm88 199 59 3 3 CD cord-021413-1ht1xm88 199 60 ° ° NN cord-021413-1ht1xm88 199 61 C c NN cord-021413-1ht1xm88 199 62 ) ) -RRB- cord-021413-1ht1xm88 199 63 . . . cord-021413-1ht1xm88 200 1 However however RB cord-021413-1ht1xm88 200 2 , , , cord-021413-1ht1xm88 200 3 they -PRON- PRP cord-021413-1ht1xm88 200 4 concluded conclude VBD cord-021413-1ht1xm88 200 5 that that IN cord-021413-1ht1xm88 200 6 a a DT cord-021413-1ht1xm88 200 7 suitable suitable JJ cord-021413-1ht1xm88 200 8 cage cage NN cord-021413-1ht1xm88 200 9 size size NN cord-021413-1ht1xm88 200 10 for for IN cord-021413-1ht1xm88 200 11 a a DT cord-021413-1ht1xm88 200 12 particular particular JJ cord-021413-1ht1xm88 200 13 species species NN cord-021413-1ht1xm88 200 14 and and CC cord-021413-1ht1xm88 200 15 number number NN cord-021413-1ht1xm88 200 16 of of IN cord-021413-1ht1xm88 200 17 ani ani NNP cord-021413-1ht1xm88 200 18 mals mal NNS cord-021413-1ht1xm88 200 19 could could MD cord-021413-1ht1xm88 200 20 compensate compensate VB cord-021413-1ht1xm88 200 21 for for IN cord-021413-1ht1xm88 200 22 the the DT cord-021413-1ht1xm88 200 23 higher high JJR cord-021413-1ht1xm88 200 24 wet wet JJ cord-021413-1ht1xm88 200 25 bulb bulb NN cord-021413-1ht1xm88 200 26 readings reading NNS cord-021413-1ht1xm88 200 27 under under IN cord-021413-1ht1xm88 200 28 filters filter NNS cord-021413-1ht1xm88 200 29 to to TO cord-021413-1ht1xm88 200 30 maintain maintain VB cord-021413-1ht1xm88 200 31 acceptable acceptable JJ cord-021413-1ht1xm88 200 32 conditions condition NNS cord-021413-1ht1xm88 200 33 for for IN cord-021413-1ht1xm88 200 34 the the DT cord-021413-1ht1xm88 200 35 animals animal NNS cord-021413-1ht1xm88 200 36 . . . cord-021413-1ht1xm88 201 1 Cur cur JJ cord-021413-1ht1xm88 201 2 rently rently RB cord-021413-1ht1xm88 201 3 , , , cord-021413-1ht1xm88 201 4 several several JJ cord-021413-1ht1xm88 201 5 types type NNS cord-021413-1ht1xm88 201 6 of of IN cord-021413-1ht1xm88 201 7 filter filter NN cord-021413-1ht1xm88 201 8 covers cover NNS cord-021413-1ht1xm88 201 9 or or CC cord-021413-1ht1xm88 201 10 bonnets bonnet NNS cord-021413-1ht1xm88 201 11 are be VBP cord-021413-1ht1xm88 201 12 available available JJ cord-021413-1ht1xm88 201 13 commercially commercially RB cord-021413-1ht1xm88 201 14 . . . cord-021413-1ht1xm88 202 1 Vaccination vaccination NN cord-021413-1ht1xm88 202 2 as as IN cord-021413-1ht1xm88 202 3 a a DT cord-021413-1ht1xm88 202 4 method method NN cord-021413-1ht1xm88 202 5 of of IN cord-021413-1ht1xm88 202 6 control control NN cord-021413-1ht1xm88 202 7 has have VBZ cord-021413-1ht1xm88 202 8 not not RB cord-021413-1ht1xm88 202 9 been be VBN cord-021413-1ht1xm88 202 10 attempted attempt VBN cord-021413-1ht1xm88 202 11 . . . cord-021413-1ht1xm88 203 1 Judging judge VBG cord-021413-1ht1xm88 203 2 from from IN cord-021413-1ht1xm88 203 3 the the DT cord-021413-1ht1xm88 203 4 lack lack NN cord-021413-1ht1xm88 203 5 of of IN cord-021413-1ht1xm88 203 6 reports report NNS cord-021413-1ht1xm88 203 7 to to IN cord-021413-1ht1xm88 203 8 the the DT cord-021413-1ht1xm88 203 9 contrary contrary NN cord-021413-1ht1xm88 203 10 , , , cord-021413-1ht1xm88 203 11 caesarian caesarian JJ cord-021413-1ht1xm88 203 12 derivation derivation NN cord-021413-1ht1xm88 203 13 together together RB cord-021413-1ht1xm88 203 14 with with IN cord-021413-1ht1xm88 203 15 barrier barrier NN cord-021413-1ht1xm88 203 16 maintenance maintenance NN cord-021413-1ht1xm88 203 17 apparently apparently RB cord-021413-1ht1xm88 203 18 elimi elimi NNP cord-021413-1ht1xm88 203 19 nates nates NNPS cord-021413-1ht1xm88 203 20 and and CC cord-021413-1ht1xm88 203 21 controls control VBZ cord-021413-1ht1xm88 203 22 the the DT cord-021413-1ht1xm88 203 23 infection infection NN cord-021413-1ht1xm88 203 24 . . . cord-021413-1ht1xm88 204 1 Kunstyf Kunstyf NNP cord-021413-1ht1xm88 204 2 ( ( -LRB- cord-021413-1ht1xm88 204 3 1962 1962 CD cord-021413-1ht1xm88 204 4 ) ) -RRB- cord-021413-1ht1xm88 204 5 attempted attempt VBD cord-021413-1ht1xm88 204 6 to to TO cord-021413-1ht1xm88 204 7 control control VB cord-021413-1ht1xm88 204 8 EDIM EDIM NNP cord-021413-1ht1xm88 204 9 by by IN cord-021413-1ht1xm88 204 10 decontamina decontamina NNP cord-021413-1ht1xm88 204 11 tion tion NN cord-021413-1ht1xm88 204 12 of of IN cord-021413-1ht1xm88 204 13 air air NN cord-021413-1ht1xm88 204 14 by by IN cord-021413-1ht1xm88 204 15 the the DT cord-021413-1ht1xm88 204 16 use use NN cord-021413-1ht1xm88 204 17 of of IN cord-021413-1ht1xm88 204 18 triethylene triethylene NNP cord-021413-1ht1xm88 204 19 glycol glycol NN cord-021413-1ht1xm88 204 20 but but CC cord-021413-1ht1xm88 204 21 was be VBD cord-021413-1ht1xm88 204 22 unable unable JJ cord-021413-1ht1xm88 204 23 to to TO cord-021413-1ht1xm88 204 24 do do VB cord-021413-1ht1xm88 204 25 so so RB cord-021413-1ht1xm88 204 26 . . . cord-021413-1ht1xm88 205 1 The the DT cord-021413-1ht1xm88 205 2 use use NN cord-021413-1ht1xm88 205 3 of of IN cord-021413-1ht1xm88 205 4 antibiotics antibiotic NNS cord-021413-1ht1xm88 205 5 , , , cord-021413-1ht1xm88 205 6 too too RB cord-021413-1ht1xm88 205 7 , , , cord-021413-1ht1xm88 205 8 is be VBZ cord-021413-1ht1xm88 205 9 without without IN cord-021413-1ht1xm88 205 10 value value NN cord-021413-1ht1xm88 205 11 , , , cord-021413-1ht1xm88 205 12 although although IN cord-021413-1ht1xm88 205 13 there there EX cord-021413-1ht1xm88 205 14 seems seem VBZ cord-021413-1ht1xm88 205 15 to to TO cord-021413-1ht1xm88 205 16 be be VB cord-021413-1ht1xm88 205 17 amelioration amelioration NN cord-021413-1ht1xm88 205 18 of of IN cord-021413-1ht1xm88 205 19 signs sign NNS cord-021413-1ht1xm88 205 20 for for IN cord-021413-1ht1xm88 205 21 a a DT cord-021413-1ht1xm88 205 22 short short JJ cord-021413-1ht1xm88 205 23 period period NN cord-021413-1ht1xm88 205 24 as as IN cord-021413-1ht1xm88 205 25 secon secon NNP cord-021413-1ht1xm88 205 26 dary dary NNP cord-021413-1ht1xm88 205 27 organisms organism NNS cord-021413-1ht1xm88 205 28 are be VBP cord-021413-1ht1xm88 205 29 temporarily temporarily RB cord-021413-1ht1xm88 205 30 reduced reduce VBN cord-021413-1ht1xm88 205 31 in in IN cord-021413-1ht1xm88 205 32 number number NN cord-021413-1ht1xm88 205 33 . . . cord-021413-1ht1xm88 206 1 As as IN cord-021413-1ht1xm88 206 2 indicated indicate VBN cord-021413-1ht1xm88 206 3 by by IN cord-021413-1ht1xm88 206 4 Kraft Kraft NNP cord-021413-1ht1xm88 206 5 ( ( -LRB- cord-021413-1ht1xm88 206 6 1966 1966 CD cord-021413-1ht1xm88 206 7 ) ) -RRB- cord-021413-1ht1xm88 206 8 , , , cord-021413-1ht1xm88 206 9 it -PRON- PRP cord-021413-1ht1xm88 206 10 may may MD cord-021413-1ht1xm88 206 11 be be VB cord-021413-1ht1xm88 206 12 relatively relatively RB cord-021413-1ht1xm88 206 13 easy easy JJ cord-021413-1ht1xm88 206 14 to to TO cord-021413-1ht1xm88 206 15 establish establish VB cord-021413-1ht1xm88 206 16 a a DT cord-021413-1ht1xm88 206 17 colony colony NN cord-021413-1ht1xm88 206 18 of of IN cord-021413-1ht1xm88 206 19 mice mouse NNS cord-021413-1ht1xm88 206 20 free free JJ cord-021413-1ht1xm88 206 21 from from IN cord-021413-1ht1xm88 206 22 EDIM EDIM NNP cord-021413-1ht1xm88 206 23 virus virus NN cord-021413-1ht1xm88 206 24 infection infection NN cord-021413-1ht1xm88 206 25 . . . cord-021413-1ht1xm88 207 1 This this DT cord-021413-1ht1xm88 207 2 may may MD cord-021413-1ht1xm88 207 3 be be VB cord-021413-1ht1xm88 207 4 accomplished accomplish VBN cord-021413-1ht1xm88 207 5 by by IN cord-021413-1ht1xm88 207 6 eliminating eliminate VBG cord-021413-1ht1xm88 207 7 those those DT cord-021413-1ht1xm88 207 8 breeding breed VBG cord-021413-1ht1xm88 207 9 pairs pair NNS cord-021413-1ht1xm88 207 10 whose whose WP$ cord-021413-1ht1xm88 207 11 first first JJ cord-021413-1ht1xm88 207 12 litter litter NN cord-021413-1ht1xm88 207 13 is be VBZ cord-021413-1ht1xm88 207 14 diarrheal diarrheal JJ cord-021413-1ht1xm88 207 15 . . . cord-021413-1ht1xm88 208 1 Filter filter NN cord-021413-1ht1xm88 208 2 devices device NNS cord-021413-1ht1xm88 208 3 are be VBP cord-021413-1ht1xm88 208 4 required require VBN cord-021413-1ht1xm88 208 5 for for IN cord-021413-1ht1xm88 208 6 this this DT cord-021413-1ht1xm88 208 7 , , , cord-021413-1ht1xm88 208 8 and and CC cord-021413-1ht1xm88 208 9 they -PRON- PRP cord-021413-1ht1xm88 208 10 and and CC cord-021413-1ht1xm88 208 11 the the DT cord-021413-1ht1xm88 208 12 animals animal NNS cord-021413-1ht1xm88 208 13 must must MD cord-021413-1ht1xm88 208 14 be be VB cord-021413-1ht1xm88 208 15 handled handle VBN cord-021413-1ht1xm88 208 16 with with IN cord-021413-1ht1xm88 208 17 the the DT cord-021413-1ht1xm88 208 18 aid aid NN cord-021413-1ht1xm88 208 19 of of IN cord-021413-1ht1xm88 208 20 a a DT cord-021413-1ht1xm88 208 21 transfer transfer NN cord-021413-1ht1xm88 208 22 or or CC cord-021413-1ht1xm88 208 23 laminar laminar JJ cord-021413-1ht1xm88 208 24 flow flow NN cord-021413-1ht1xm88 208 25 hood hood NN cord-021413-1ht1xm88 208 26 using use VBG cord-021413-1ht1xm88 208 27 sterile sterile JJ cord-021413-1ht1xm88 208 28 techniques technique NNS cord-021413-1ht1xm88 208 29 during during IN cord-021413-1ht1xm88 208 30 observation observation NN cord-021413-1ht1xm88 208 31 and and CC cord-021413-1ht1xm88 208 32 handling handling NN cord-021413-1ht1xm88 208 33 of of IN cord-021413-1ht1xm88 208 34 the the DT cord-021413-1ht1xm88 208 35 animals animal NNS cord-021413-1ht1xm88 208 36 . . . cord-021413-1ht1xm88 209 1 The the DT cord-021413-1ht1xm88 209 2 method method NN cord-021413-1ht1xm88 209 3 is be VBZ cord-021413-1ht1xm88 209 4 suita suita NNP cord-021413-1ht1xm88 209 5 ble ble NNP cord-021413-1ht1xm88 209 6 for for IN cord-021413-1ht1xm88 209 7 small small JJ cord-021413-1ht1xm88 209 8 colonies colony NNS cord-021413-1ht1xm88 209 9 , , , cord-021413-1ht1xm88 209 10 but but CC cord-021413-1ht1xm88 209 11 it -PRON- PRP cord-021413-1ht1xm88 209 12 is be VBZ cord-021413-1ht1xm88 209 13 impractical impractical JJ cord-021413-1ht1xm88 209 14 for for IN cord-021413-1ht1xm88 209 15 commerce commerce NN cord-021413-1ht1xm88 209 16 where where WRB cord-021413-1ht1xm88 209 17 caesarian caesarian JJ cord-021413-1ht1xm88 209 18 derivation derivation NN cord-021413-1ht1xm88 209 19 and and CC cord-021413-1ht1xm88 209 20 barrier barrier NN cord-021413-1ht1xm88 209 21 maintenance maintenance NN cord-021413-1ht1xm88 209 22 are be VBP cord-021413-1ht1xm88 209 23 the the DT cord-021413-1ht1xm88 209 24 methods method NNS cord-021413-1ht1xm88 209 25 of of IN cord-021413-1ht1xm88 209 26 choice choice NN cord-021413-1ht1xm88 209 27 . . . cord-021413-1ht1xm88 210 1 Reovirus Reovirus NNP cord-021413-1ht1xm88 210 2 3 3 CD cord-021413-1ht1xm88 210 3 was be VBD cord-021413-1ht1xm88 210 4 first first RB cord-021413-1ht1xm88 210 5 isolated isolate VBN cord-021413-1ht1xm88 210 6 from from IN cord-021413-1ht1xm88 210 7 the the DT cord-021413-1ht1xm88 210 8 feces fece NNS cord-021413-1ht1xm88 210 9 of of IN cord-021413-1ht1xm88 210 10 an an DT cord-021413-1ht1xm88 210 11 Australian australian JJ cord-021413-1ht1xm88 210 12 child child NN cord-021413-1ht1xm88 210 13 manifesting manifest VBG cord-021413-1ht1xm88 210 14 a a DT cord-021413-1ht1xm88 210 15 cough cough NN cord-021413-1ht1xm88 210 16 , , , cord-021413-1ht1xm88 210 17 fever fever NN cord-021413-1ht1xm88 210 18 , , , cord-021413-1ht1xm88 210 19 vomiting vomiting NN cord-021413-1ht1xm88 210 20 , , , cord-021413-1ht1xm88 210 21 hypertrophic hypertrophic JJ cord-021413-1ht1xm88 210 22 tonsils tonsil NNS cord-021413-1ht1xm88 210 23 , , , cord-021413-1ht1xm88 210 24 and and CC cord-021413-1ht1xm88 210 25 bilateral bilateral JJ cord-021413-1ht1xm88 210 26 bronchopneumonia bronchopneumonia NN cord-021413-1ht1xm88 210 27 . . . cord-021413-1ht1xm88 211 1 It -PRON- PRP cord-021413-1ht1xm88 211 2 was be VBD cord-021413-1ht1xm88 211 3 named name VBN cord-021413-1ht1xm88 211 4 hepatoencephalomyelitis hepatoencephalomyelitis NN cord-021413-1ht1xm88 211 5 virus virus NN cord-021413-1ht1xm88 211 6 by by IN cord-021413-1ht1xm88 211 7 Stanley Stanley NNP cord-021413-1ht1xm88 211 8 et et NNP cord-021413-1ht1xm88 211 9 al al NNP cord-021413-1ht1xm88 211 10 . . . cord-021413-1ht1xm88 212 1 ( ( -LRB- cord-021413-1ht1xm88 212 2 1953 1953 CD cord-021413-1ht1xm88 212 3 ) ) -RRB- cord-021413-1ht1xm88 212 4 , , , cord-021413-1ht1xm88 212 5 who who WP cord-021413-1ht1xm88 212 6 originally originally RB cord-021413-1ht1xm88 212 7 recovered recover VBD cord-021413-1ht1xm88 212 8 the the DT cord-021413-1ht1xm88 212 9 agent agent NN cord-021413-1ht1xm88 212 10 . . . cord-021413-1ht1xm88 213 1 Sabin Sabin NNP cord-021413-1ht1xm88 213 2 ( ( -LRB- cord-021413-1ht1xm88 213 3 1959 1959 CD cord-021413-1ht1xm88 213 4 ) ) -RRB- cord-021413-1ht1xm88 213 5 proposed propose VBD cord-021413-1ht1xm88 213 6 the the DT cord-021413-1ht1xm88 213 7 name name NN cord-021413-1ht1xm88 213 8 reovirus reovirus NNP cord-021413-1ht1xm88 213 9 for for IN cord-021413-1ht1xm88 213 10 a a DT cord-021413-1ht1xm88 213 11 group group NN cord-021413-1ht1xm88 213 12 of of IN cord-021413-1ht1xm88 213 13 agents agent NNS cord-021413-1ht1xm88 213 14 associated associate VBN cord-021413-1ht1xm88 213 15 with with IN cord-021413-1ht1xm88 213 16 the the DT cord-021413-1ht1xm88 213 17 respi respi NNP cord-021413-1ht1xm88 213 18 ratory ratory NNP cord-021413-1ht1xm88 213 19 and and CC cord-021413-1ht1xm88 213 20 enteric enteric JJ cord-021413-1ht1xm88 213 21 tracts tract NNS cord-021413-1ht1xm88 213 22 of of IN cord-021413-1ht1xm88 213 23 humans human NNS cord-021413-1ht1xm88 213 24 . . . cord-021413-1ht1xm88 214 1 They -PRON- PRP cord-021413-1ht1xm88 214 2 were be VBD cord-021413-1ht1xm88 214 3 found find VBN cord-021413-1ht1xm88 214 4 to to TO cord-021413-1ht1xm88 214 5 be be VB cord-021413-1ht1xm88 214 6 ether ether NN cord-021413-1ht1xm88 214 7 resistant resistant JJ cord-021413-1ht1xm88 214 8 , , , cord-021413-1ht1xm88 214 9 about about RB cord-021413-1ht1xm88 214 10 70 70 CD cord-021413-1ht1xm88 214 11 nm nm NN cord-021413-1ht1xm88 214 12 in in IN cord-021413-1ht1xm88 214 13 size size NN cord-021413-1ht1xm88 214 14 by by IN cord-021413-1ht1xm88 214 15 membrane membrane NN cord-021413-1ht1xm88 214 16 filtration filtration NN cord-021413-1ht1xm88 214 17 but but CC cord-021413-1ht1xm88 214 18 of of IN cord-021413-1ht1xm88 214 19 unknown unknown JJ cord-021413-1ht1xm88 214 20 shape shape NN cord-021413-1ht1xm88 214 21 , , , cord-021413-1ht1xm88 214 22 and and CC cord-021413-1ht1xm88 214 23 caused cause VBD cord-021413-1ht1xm88 214 24 distinctive distinctive JJ cord-021413-1ht1xm88 214 25 cytopathic cytopathic JJ cord-021413-1ht1xm88 214 26 effects effect NNS cord-021413-1ht1xm88 214 27 in in IN cord-021413-1ht1xm88 214 28 monkey monkey NN cord-021413-1ht1xm88 214 29 kidney kidney NN cord-021413-1ht1xm88 214 30 tissue tissue NN cord-021413-1ht1xm88 214 31 cultures culture NNS cord-021413-1ht1xm88 214 32 . . . cord-021413-1ht1xm88 215 1 One one CD cord-021413-1ht1xm88 215 2 of of IN cord-021413-1ht1xm88 215 3 the the DT cord-021413-1ht1xm88 215 4 ECHO ECHO NNP cord-021413-1ht1xm88 215 5 group group NN cord-021413-1ht1xm88 215 6 of of IN cord-021413-1ht1xm88 215 7 viruses virus NNS cord-021413-1ht1xm88 215 8 , , , cord-021413-1ht1xm88 215 9 ECHO ECHO NNP cord-021413-1ht1xm88 215 10 10 10 CD cord-021413-1ht1xm88 215 11 , , , cord-021413-1ht1xm88 215 12 now now RB cord-021413-1ht1xm88 215 13 synonymous synonymous JJ cord-021413-1ht1xm88 215 14 with with IN cord-021413-1ht1xm88 215 15 reovirus reovirus NNP cord-021413-1ht1xm88 215 16 , , , cord-021413-1ht1xm88 215 17 became become VBD cord-021413-1ht1xm88 215 18 a a DT cord-021413-1ht1xm88 215 19 member member NN cord-021413-1ht1xm88 215 20 of of IN cord-021413-1ht1xm88 215 21 the the DT cord-021413-1ht1xm88 215 22 new new JJ cord-021413-1ht1xm88 215 23 group group NN cord-021413-1ht1xm88 215 24 on on IN cord-021413-1ht1xm88 215 25 that that DT cord-021413-1ht1xm88 215 26 basis basis NN cord-021413-1ht1xm88 215 27 . . . cord-021413-1ht1xm88 216 1 ( ( -LRB- cord-021413-1ht1xm88 216 2 ECHO ECHO NNP cord-021413-1ht1xm88 216 3 is be VBZ cord-021413-1ht1xm88 216 4 the the DT cord-021413-1ht1xm88 216 5 acronym acronym NN cord-021413-1ht1xm88 216 6 for for IN cord-021413-1ht1xm88 216 7 enteric enteric JJ cord-021413-1ht1xm88 216 8 cytopathic cytopathic JJ cord-021413-1ht1xm88 216 9 /zuman /zuman . cord-021413-1ht1xm88 216 10 6 6 CD cord-021413-1ht1xm88 217 1 > > XX cord-021413-1ht1xm88 218 1 φhan φhan NNP cord-021413-1ht1xm88 218 2 , , , cord-021413-1ht1xm88 218 3 agents agent NNS cord-021413-1ht1xm88 218 4 isolated isolate VBN cord-021413-1ht1xm88 218 5 in in IN cord-021413-1ht1xm88 218 6 tissue tissue NN cord-021413-1ht1xm88 218 7 culture culture NN cord-021413-1ht1xm88 218 8 from from IN cord-021413-1ht1xm88 218 9 asymptomatic asymptomatic JJ cord-021413-1ht1xm88 218 10 humans human NNS cord-021413-1ht1xm88 218 11 - - HYPH cord-021413-1ht1xm88 218 12 so so RB cord-021413-1ht1xm88 218 13 - - HYPH cord-021413-1ht1xm88 218 14 called call VBN cord-021413-1ht1xm88 218 15 viruses virus NNS cord-021413-1ht1xm88 218 16 in in IN cord-021413-1ht1xm88 218 17 search search NN cord-021413-1ht1xm88 218 18 of of IN cord-021413-1ht1xm88 218 19 disease disease NN cord-021413-1ht1xm88 218 20 . . . cord-021413-1ht1xm88 218 21 ) ) -RRB- cord-021413-1ht1xm88 219 1 Stanley Stanley NNP cord-021413-1ht1xm88 219 2 ( ( -LRB- cord-021413-1ht1xm88 219 3 1961 1961 CD cord-021413-1ht1xm88 219 4 ) ) -RRB- cord-021413-1ht1xm88 219 5 then then RB cord-021413-1ht1xm88 219 6 demonstrated demonstrate VBD cord-021413-1ht1xm88 219 7 that that IN cord-021413-1ht1xm88 219 8 the the DT cord-021413-1ht1xm88 219 9 hepatoencephalomyelitis hepatoencephalomyelitis NN cord-021413-1ht1xm88 219 10 virus virus NN cord-021413-1ht1xm88 219 11 was be VBD cord-021413-1ht1xm88 219 12 serologically serologically RB cord-021413-1ht1xm88 219 13 identical identical JJ cord-021413-1ht1xm88 219 14 to to IN cord-021413-1ht1xm88 219 15 reovirus reovirus NNP cord-021413-1ht1xm88 219 16 3 3 CD cord-021413-1ht1xm88 219 17 . . . cord-021413-1ht1xm88 220 1 Additional additional JJ cord-021413-1ht1xm88 220 2 strains strain NNS cord-021413-1ht1xm88 220 3 have have VBP cord-021413-1ht1xm88 220 4 since since IN cord-021413-1ht1xm88 220 5 been be VBN cord-021413-1ht1xm88 220 6 recovered recover VBN cord-021413-1ht1xm88 220 7 from from IN cord-021413-1ht1xm88 220 8 humans human NNS cord-021413-1ht1xm88 220 9 , , , cord-021413-1ht1xm88 220 10 other other JJ cord-021413-1ht1xm88 220 11 mammals mammal NNS cord-021413-1ht1xm88 220 12 , , , cord-021413-1ht1xm88 220 13 marsupials marsupial NNS cord-021413-1ht1xm88 220 14 , , , cord-021413-1ht1xm88 220 15 birds bird NNS cord-021413-1ht1xm88 220 16 , , , cord-021413-1ht1xm88 220 17 insects insect NNS cord-021413-1ht1xm88 220 18 , , , cord-021413-1ht1xm88 220 19 and and CC cord-021413-1ht1xm88 220 20 reptiles reptile NNS cord-021413-1ht1xm88 220 21 ( ( -LRB- cord-021413-1ht1xm88 220 22 for for IN cord-021413-1ht1xm88 220 23 review review NN cord-021413-1ht1xm88 220 24 , , , cord-021413-1ht1xm88 220 25 see see VB cord-021413-1ht1xm88 220 26 Stanley Stanley NNP cord-021413-1ht1xm88 220 27 , , , cord-021413-1ht1xm88 220 28 1974 1974 CD cord-021413-1ht1xm88 220 29 ) ) -RRB- cord-021413-1ht1xm88 220 30 , , , cord-021413-1ht1xm88 220 31 and and CC cord-021413-1ht1xm88 220 32 from from IN cord-021413-1ht1xm88 220 33 moUusks moUusks NNP cord-021413-1ht1xm88 220 34 ( ( -LRB- cord-021413-1ht1xm88 220 35 Meyers Meyers NNP cord-021413-1ht1xm88 220 36 , , , cord-021413-1ht1xm88 220 37 1979 1979 CD cord-021413-1ht1xm88 220 38 ; ; : cord-021413-1ht1xm88 220 39 Meyers Meyers NNP cord-021413-1ht1xm88 220 40 and and CC cord-021413-1ht1xm88 220 41 Hirai Hirai NNP cord-021413-1ht1xm88 220 42 , , , cord-021413-1ht1xm88 220 43 1980 1980 CD cord-021413-1ht1xm88 220 44 ) ) -RRB- cord-021413-1ht1xm88 220 45 . . . cord-021413-1ht1xm88 221 1 Reoviruses reovirus NNS cord-021413-1ht1xm88 221 2 have have VBP cord-021413-1ht1xm88 221 3 been be VBN cord-021413-1ht1xm88 221 4 divided divide VBN cord-021413-1ht1xm88 221 5 into into IN cord-021413-1ht1xm88 221 6 three three CD cord-021413-1ht1xm88 221 7 serotypes serotype NNS cord-021413-1ht1xm88 221 8 on on IN cord-021413-1ht1xm88 221 9 the the DT cord-021413-1ht1xm88 221 10 basis basis NN cord-021413-1ht1xm88 221 11 of of IN cord-021413-1ht1xm88 221 12 hemagglutination hemagglutination NN cord-021413-1ht1xm88 221 13 inhibition inhibition NN cord-021413-1ht1xm88 221 14 and and CC cord-021413-1ht1xm88 221 15 neutralization neutralization NN cord-021413-1ht1xm88 221 16 tests test NNS cord-021413-1ht1xm88 221 17 ( ( -LRB- cord-021413-1ht1xm88 221 18 Sabin Sabin NNP cord-021413-1ht1xm88 221 19 , , , cord-021413-1ht1xm88 221 20 1959 1959 CD cord-021413-1ht1xm88 221 21 ; ; : cord-021413-1ht1xm88 221 22 Rosen Rosen NNP cord-021413-1ht1xm88 221 23 , , , cord-021413-1ht1xm88 221 24 1960 1960 CD cord-021413-1ht1xm88 221 25 ) ) -RRB- cord-021413-1ht1xm88 221 26 . . . cord-021413-1ht1xm88 222 1 Reovirus Reovirus NNP cord-021413-1ht1xm88 222 2 3 3 CD cord-021413-1ht1xm88 222 3 was be VBD cord-021413-1ht1xm88 222 4 established establish VBN cord-021413-1ht1xm88 222 5 as as IN cord-021413-1ht1xm88 222 6 an an DT cord-021413-1ht1xm88 222 7 indigenous indigenous JJ cord-021413-1ht1xm88 222 8 murine murine JJ cord-021413-1ht1xm88 222 9 virus virus NN cord-021413-1ht1xm88 222 10 by by IN cord-021413-1ht1xm88 222 11 Hartley Hartley NNP cord-021413-1ht1xm88 222 12 et et NNP cord-021413-1ht1xm88 222 13 al al NNP cord-021413-1ht1xm88 222 14 . . . cord-021413-1ht1xm88 223 1 ( ( -LRB- cord-021413-1ht1xm88 223 2 1961 1961 CD cord-021413-1ht1xm88 223 3 ) ) -RRB- cord-021413-1ht1xm88 224 1 and and CC cord-021413-1ht1xm88 224 2 by by IN cord-021413-1ht1xm88 224 3 Cook Cook NNP cord-021413-1ht1xm88 224 4 ( ( -LRB- cord-021413-1ht1xm88 224 5 1963 1963 CD cord-021413-1ht1xm88 224 6 ) ) -RRB- cord-021413-1ht1xm88 224 7 . . . cord-021413-1ht1xm88 225 1 Reviews review NNS cord-021413-1ht1xm88 225 2 concerning concern VBG cord-021413-1ht1xm88 225 3 the the DT cord-021413-1ht1xm88 225 4 biological biological JJ cord-021413-1ht1xm88 225 5 and and CC cord-021413-1ht1xm88 225 6 clinical clinical JJ cord-021413-1ht1xm88 225 7 aspects aspect NNS cord-021413-1ht1xm88 225 8 of of IN cord-021413-1ht1xm88 225 9 disease disease NN cord-021413-1ht1xm88 225 10 caused cause VBN cord-021413-1ht1xm88 225 11 by by IN cord-021413-1ht1xm88 225 12 this this DT cord-021413-1ht1xm88 225 13 agent agent NN cord-021413-1ht1xm88 225 14 have have VBP cord-021413-1ht1xm88 225 15 been be VBN cord-021413-1ht1xm88 225 16 prepared prepare VBN cord-021413-1ht1xm88 225 17 ( ( -LRB- cord-021413-1ht1xm88 225 18 Stanley Stanley NNP cord-021413-1ht1xm88 225 19 , , , cord-021413-1ht1xm88 225 20 1974 1974 CD cord-021413-1ht1xm88 225 21 ( ( -LRB- cord-021413-1ht1xm88 225 22 Stanley Stanley NNP cord-021413-1ht1xm88 225 23 , , , cord-021413-1ht1xm88 225 24 , , , cord-021413-1ht1xm88 225 25 1977 1977 CD cord-021413-1ht1xm88 225 26 . . . cord-021413-1ht1xm88 226 1 When when WRB cord-021413-1ht1xm88 226 2 Gomatos Gomatos NNP cord-021413-1ht1xm88 226 3 et et NNP cord-021413-1ht1xm88 226 4 al al NNP cord-021413-1ht1xm88 226 5 . . . cord-021413-1ht1xm88 227 1 ( ( -LRB- cord-021413-1ht1xm88 227 2 1962 1962 CD cord-021413-1ht1xm88 227 3 ) ) -RRB- cord-021413-1ht1xm88 227 4 and and CC cord-021413-1ht1xm88 227 5 discovered discover VBD cord-021413-1ht1xm88 227 6 that that IN cord-021413-1ht1xm88 227 7 reoviruses reovirus NNS cord-021413-1ht1xm88 227 8 possess possess VBP cord-021413-1ht1xm88 227 9 double double RB cord-021413-1ht1xm88 227 10 - - HYPH cord-021413-1ht1xm88 227 11 stranded strand VBN cord-021413-1ht1xm88 227 12 RNA RNA NNP cord-021413-1ht1xm88 227 13 , , , cord-021413-1ht1xm88 227 14 a a DT cord-021413-1ht1xm88 227 15 unique unique JJ cord-021413-1ht1xm88 227 16 characteristic characteristic NN cord-021413-1ht1xm88 227 17 among among IN cord-021413-1ht1xm88 227 18 viruses virus NNS cord-021413-1ht1xm88 227 19 , , , cord-021413-1ht1xm88 227 20 molecular molecular JJ cord-021413-1ht1xm88 227 21 biologists biologist NNS cord-021413-1ht1xm88 227 22 were be VBD cord-021413-1ht1xm88 227 23 inspired inspire VBN cord-021413-1ht1xm88 227 24 to to TO cord-021413-1ht1xm88 227 25 study study VB cord-021413-1ht1xm88 227 26 them -PRON- PRP cord-021413-1ht1xm88 227 27 in in IN cord-021413-1ht1xm88 227 28 minute minute NN cord-021413-1ht1xm88 227 29 detail detail NN cord-021413-1ht1xm88 227 30 . . . cord-021413-1ht1xm88 228 1 Currently currently RB cord-021413-1ht1xm88 228 2 , , , cord-021413-1ht1xm88 228 3 knowledge knowledge NN cord-021413-1ht1xm88 228 4 of of IN cord-021413-1ht1xm88 228 5 reovirus reovirus JJ cord-021413-1ht1xm88 228 6 replication replication NN cord-021413-1ht1xm88 228 7 on on IN cord-021413-1ht1xm88 228 8 biochemical biochemical JJ cord-021413-1ht1xm88 228 9 and and CC cord-021413-1ht1xm88 228 10 biophysical biophysical JJ cord-021413-1ht1xm88 228 11 planes plane NNS cord-021413-1ht1xm88 228 12 is be VBZ cord-021413-1ht1xm88 228 13 as as RB cord-021413-1ht1xm88 228 14 extensive extensive JJ cord-021413-1ht1xm88 228 15 as as IN cord-021413-1ht1xm88 228 16 that that DT cord-021413-1ht1xm88 228 17 available available JJ cord-021413-1ht1xm88 228 18 for for IN cord-021413-1ht1xm88 228 19 any any DT cord-021413-1ht1xm88 228 20 other other JJ cord-021413-1ht1xm88 228 21 virus virus NN cord-021413-1ht1xm88 228 22 and and CC cord-021413-1ht1xm88 228 23 is be VBZ cord-021413-1ht1xm88 228 24 , , , cord-021413-1ht1xm88 228 25 for for IN cord-021413-1ht1xm88 228 26 the the DT cord-021413-1ht1xm88 228 27 most most JJS cord-021413-1ht1xm88 228 28 part part NN cord-021413-1ht1xm88 228 29 , , , cord-021413-1ht1xm88 228 30 outside outside IN cord-021413-1ht1xm88 228 31 the the DT cord-021413-1ht1xm88 228 32 scope scope NN cord-021413-1ht1xm88 228 33 of of IN cord-021413-1ht1xm88 228 34 this this DT cord-021413-1ht1xm88 228 35 chapter chapter NN cord-021413-1ht1xm88 228 36 . . . cord-021413-1ht1xm88 229 1 Interested interested JJ cord-021413-1ht1xm88 229 2 readers reader NNS cord-021413-1ht1xm88 229 3 are be VBP cord-021413-1ht1xm88 229 4 therefore therefore RB cord-021413-1ht1xm88 229 5 referred refer VBN cord-021413-1ht1xm88 229 6 to to IN cord-021413-1ht1xm88 229 7 reviews review NNS cord-021413-1ht1xm88 229 8 by by IN cord-021413-1ht1xm88 229 9 Shatkin Shatkin NNP cord-021413-1ht1xm88 229 10 ( ( -LRB- cord-021413-1ht1xm88 229 11 1969 1969 CD cord-021413-1ht1xm88 229 12 ) ) -RRB- cord-021413-1ht1xm88 229 13 and and CC cord-021413-1ht1xm88 229 14 Joklik Joklik NNP cord-021413-1ht1xm88 229 15 ( ( -LRB- cord-021413-1ht1xm88 229 16 1974 1974 CD cord-021413-1ht1xm88 229 17 ) ) -RRB- cord-021413-1ht1xm88 229 18 for for IN cord-021413-1ht1xm88 229 19 extended extended JJ cord-021413-1ht1xm88 229 20 literature literature NN cord-021413-1ht1xm88 229 21 coverage coverage NN cord-021413-1ht1xm88 229 22 and and CC cord-021413-1ht1xm88 229 23 detailed detailed JJ cord-021413-1ht1xm88 229 24 dis dis NN cord-021413-1ht1xm88 229 25 cussion cussion NN cord-021413-1ht1xm88 229 26 and and CC cord-021413-1ht1xm88 229 27 to to IN cord-021413-1ht1xm88 229 28 Andrewes Andrewes NNP cord-021413-1ht1xm88 229 29 et et FW cord-021413-1ht1xm88 229 30 al al NNP cord-021413-1ht1xm88 229 31 . . . cord-021413-1ht1xm88 230 1 ( ( -LRB- cord-021413-1ht1xm88 230 2 1978 1978 CD cord-021413-1ht1xm88 230 3 ) ) -RRB- cord-021413-1ht1xm88 230 4 for for IN cord-021413-1ht1xm88 230 5 a a DT cord-021413-1ht1xm88 230 6 condensed condense VBN cord-021413-1ht1xm88 230 7 over over IN cord-021413-1ht1xm88 230 8 view view NN cord-021413-1ht1xm88 230 9 . . . cord-021413-1ht1xm88 231 1 or or CC cord-021413-1ht1xm88 231 2 Reovirus Reovirus NNP cord-021413-1ht1xm88 231 3 , , , cord-021413-1ht1xm88 231 4 in in IN cord-021413-1ht1xm88 231 5 the the DT cord-021413-1ht1xm88 231 6 family family NN cord-021413-1ht1xm88 231 7 Reoviridae Reoviridae NNP cord-021413-1ht1xm88 231 8 ( ( -LRB- cord-021413-1ht1xm88 231 9 Melnick Melnick NNP cord-021413-1ht1xm88 231 10 , , , cord-021413-1ht1xm88 231 11 1979 1979 CD cord-021413-1ht1xm88 231 12 ) ) -RRB- cord-021413-1ht1xm88 231 13 . . . cord-021413-1ht1xm88 232 1 Wild wild JJ cord-021413-1ht1xm88 232 2 - - HYPH cord-021413-1ht1xm88 232 3 type type NN cord-021413-1ht1xm88 232 4 strains strain NNS cord-021413-1ht1xm88 232 5 of of IN cord-021413-1ht1xm88 232 6 reovirus reovirus NNP cord-021413-1ht1xm88 232 7 3 3 CD cord-021413-1ht1xm88 232 8 include include VBP cord-021413-1ht1xm88 232 9 : : : cord-021413-1ht1xm88 232 10 Dearing Dearing NNP cord-021413-1ht1xm88 232 11 , , , cord-021413-1ht1xm88 232 12 the the DT cord-021413-1ht1xm88 232 13 pro pro JJ cord-021413-1ht1xm88 232 14 totype totype NN cord-021413-1ht1xm88 232 15 strain strain NN cord-021413-1ht1xm88 232 16 ( ( -LRB- cord-021413-1ht1xm88 232 17 Sabin Sabin NNP cord-021413-1ht1xm88 232 18 , , , cord-021413-1ht1xm88 232 19 1959 1959 CD cord-021413-1ht1xm88 232 20 ) ) -RRB- cord-021413-1ht1xm88 232 21 , , , cord-021413-1ht1xm88 232 22 isolated isolate VBN cord-021413-1ht1xm88 232 23 from from IN cord-021413-1ht1xm88 232 24 a a DT cord-021413-1ht1xm88 232 25 child child NN cord-021413-1ht1xm88 232 26 with with IN cord-021413-1ht1xm88 232 27 diarrhea diarrhea NN cord-021413-1ht1xm88 232 28 ; ; : cord-021413-1ht1xm88 232 29 Abney Abney NNP cord-021413-1ht1xm88 232 30 ( ( -LRB- cord-021413-1ht1xm88 232 31 Rosen Rosen NNP cord-021413-1ht1xm88 232 32 , , , cord-021413-1ht1xm88 232 33 1960 1960 CD cord-021413-1ht1xm88 232 34 ) ) -RRB- cord-021413-1ht1xm88 232 35 , , , cord-021413-1ht1xm88 232 36 isolated isolate VBN cord-021413-1ht1xm88 232 37 from from IN cord-021413-1ht1xm88 232 38 a a DT cord-021413-1ht1xm88 232 39 child child NN cord-021413-1ht1xm88 232 40 with with IN cord-021413-1ht1xm88 232 41 a a DT cord-021413-1ht1xm88 232 42 febrile febrile JJ cord-021413-1ht1xm88 232 43 upper upper JJ cord-021413-1ht1xm88 232 44 respiratory respiratory JJ cord-021413-1ht1xm88 232 45 infection infection NN cord-021413-1ht1xm88 232 46 ; ; : cord-021413-1ht1xm88 232 47 CAN CAN MD cord-021413-1ht1xm88 232 48 230 230 CD cord-021413-1ht1xm88 232 49 , , , cord-021413-1ht1xm88 232 50 from from IN cord-021413-1ht1xm88 232 51 a a DT cord-021413-1ht1xm88 232 52 case case NN cord-021413-1ht1xm88 232 53 of of IN cord-021413-1ht1xm88 232 54 Burkitt Burkitt NNP cord-021413-1ht1xm88 232 55 's 's POS cord-021413-1ht1xm88 232 56 lymphoma lymphoma NN cord-021413-1ht1xm88 232 57 ( ( -LRB- cord-021413-1ht1xm88 232 58 Bell Bell NNP cord-021413-1ht1xm88 232 59 et et NNP cord-021413-1ht1xm88 232 60 al al NNP cord-021413-1ht1xm88 232 61 . . NNP cord-021413-1ht1xm88 232 62 , , , cord-021413-1ht1xm88 232 63 1964 1964 CD cord-021413-1ht1xm88 232 64 ) ) -RRB- cord-021413-1ht1xm88 232 65 ; ; : cord-021413-1ht1xm88 232 66 and and CC cord-021413-1ht1xm88 232 67 several several JJ cord-021413-1ht1xm88 232 68 strains strain NNS cord-021413-1ht1xm88 232 69 obtained obtain VBN cord-021413-1ht1xm88 232 70 from from IN cord-021413-1ht1xm88 232 71 naturally naturally RB cord-021413-1ht1xm88 232 72 infected infect VBN cord-021413-1ht1xm88 232 73 cattle cattle NNS cord-021413-1ht1xm88 232 74 ( ( -LRB- cord-021413-1ht1xm88 232 75 Rosen Rosen NNP cord-021413-1ht1xm88 232 76 , , , cord-021413-1ht1xm88 232 77 1960 1960 CD cord-021413-1ht1xm88 232 78 ) ) -RRB- cord-021413-1ht1xm88 232 79 . . . cord-021413-1ht1xm88 233 1 Mutant mutant JJ cord-021413-1ht1xm88 233 2 , , , cord-021413-1ht1xm88 233 3 temperature temperature NN cord-021413-1ht1xm88 233 4 - - HYPH cord-021413-1ht1xm88 233 5 sensitive sensitive JJ cord-021413-1ht1xm88 233 6 ( ( -LRB- cord-021413-1ht1xm88 233 7 ts ts NN cord-021413-1ht1xm88 233 8 ) ) -RRB- cord-021413-1ht1xm88 233 9 strains strain NNS cord-021413-1ht1xm88 233 10 have have VBP cord-021413-1ht1xm88 233 11 been be VBN cord-021413-1ht1xm88 233 12 developed develop VBN cord-021413-1ht1xm88 233 13 in in IN cord-021413-1ht1xm88 233 14 the the DT cord-021413-1ht1xm88 233 15 laboratory laboratory NN cord-021413-1ht1xm88 233 16 ( ( -LRB- cord-021413-1ht1xm88 233 17 Fields field NNS cord-021413-1ht1xm88 233 18 and and CC cord-021413-1ht1xm88 233 19 Joklik Joklik NNP cord-021413-1ht1xm88 233 20 , , , cord-021413-1ht1xm88 233 21 1969 1969 CD cord-021413-1ht1xm88 233 22 ) ) -RRB- cord-021413-1ht1xm88 233 23 and and CC cord-021413-1ht1xm88 233 24 have have VBP cord-021413-1ht1xm88 233 25 been be VBN cord-021413-1ht1xm88 233 26 used use VBN cord-021413-1ht1xm88 233 27 for for IN cord-021413-1ht1xm88 233 28 studying study VBG cord-021413-1ht1xm88 233 29 the the DT cord-021413-1ht1xm88 233 30 synthesis synthesis NN cord-021413-1ht1xm88 233 31 of of IN cord-021413-1ht1xm88 233 32 viral viral JJ cord-021413-1ht1xm88 233 33 RNA RNA NNP cord-021413-1ht1xm88 233 34 and and CC cord-021413-1ht1xm88 233 35 peptides peptide NNS cord-021413-1ht1xm88 233 36 ( ( -LRB- cord-021413-1ht1xm88 233 37 Cross Cross NNP cord-021413-1ht1xm88 233 38 and and CC cord-021413-1ht1xm88 233 39 Fields Fields NNP cord-021413-1ht1xm88 233 40 , , , cord-021413-1ht1xm88 233 41 1972 1972 CD cord-021413-1ht1xm88 233 42 ; ; : cord-021413-1ht1xm88 233 43 as as RB cord-021413-1ht1xm88 233 44 well well RB cord-021413-1ht1xm88 233 45 as as IN cord-021413-1ht1xm88 233 46 for for IN cord-021413-1ht1xm88 233 47 examining examine VBG cord-021413-1ht1xm88 233 48 problems problem NNS cord-021413-1ht1xm88 233 49 of of IN cord-021413-1ht1xm88 233 50 pathogenesis pathogenesis NN cord-021413-1ht1xm88 233 51 . . . cord-021413-1ht1xm88 234 1 A a DT cord-021413-1ht1xm88 234 2 neurotropic neurotropic NNP cord-021413-1ht1xm88 234 3 strain strain NN cord-021413-1ht1xm88 234 4 was be VBD cord-021413-1ht1xm88 234 5 also also RB cord-021413-1ht1xm88 234 6 de de JJ cord-021413-1ht1xm88 234 7 - - VBN cord-021413-1ht1xm88 234 8 rived rive VBN cord-021413-1ht1xm88 234 9 from from IN cord-021413-1ht1xm88 234 10 the the DT cord-021413-1ht1xm88 234 11 m m NNP cord-021413-1ht1xm88 234 12 o o NN cord-021413-1ht1xm88 234 13 r r NN cord-021413-1ht1xm88 234 14 e e NN cord-021413-1ht1xm88 234 15 hepatotropic hepatotropic NNP cord-021413-1ht1xm88 234 16 original original JJ cord-021413-1ht1xm88 234 17 isolate isolate NN cord-021413-1ht1xm88 234 18 ( ( -LRB- cord-021413-1ht1xm88 234 19 Stanley Stanley NNP cord-021413-1ht1xm88 234 20 et et NNP cord-021413-1ht1xm88 234 21 aL aL NNP cord-021413-1ht1xm88 234 22 , , , cord-021413-1ht1xm88 234 23 1954 1954 CD cord-021413-1ht1xm88 234 24 ) ) -RRB- cord-021413-1ht1xm88 234 25 . . . cord-021413-1ht1xm88 235 1 T T NNP cord-021413-1ht1xm88 235 2 h h NN cord-021413-1ht1xm88 235 3 e e NN cord-021413-1ht1xm88 235 4 reovirus reovirus NNP cord-021413-1ht1xm88 235 5 3 3 CD cord-021413-1ht1xm88 235 6 virion virion NN cord-021413-1ht1xm88 235 7 ( ( -LRB- cord-021413-1ht1xm88 235 8 Fig Fig NNP cord-021413-1ht1xm88 235 9 . . . cord-021413-1ht1xm88 235 10 3 3 LS cord-021413-1ht1xm88 235 11 ) ) -RRB- cord-021413-1ht1xm88 235 12 has have VBZ cord-021413-1ht1xm88 235 13 a a DT cord-021413-1ht1xm88 235 14 m m NNP cord-021413-1ht1xm88 235 15 e e NN cord-021413-1ht1xm88 235 16 a a NN cord-021413-1ht1xm88 235 17 n n NN cord-021413-1ht1xm88 235 18 diameter diameter NN cord-021413-1ht1xm88 235 19 of of IN cord-021413-1ht1xm88 235 20 about about RB cord-021413-1ht1xm88 235 21 6 6 CD cord-021413-1ht1xm88 235 22 0 0 CD cord-021413-1ht1xm88 235 23 -7 -7 . cord-021413-1ht1xm88 236 1 6 6 CD cord-021413-1ht1xm88 236 2 n n NN cord-021413-1ht1xm88 236 3 m m NN cord-021413-1ht1xm88 236 4 and and CC cord-021413-1ht1xm88 236 5 is be VBZ cord-021413-1ht1xm88 236 6 icosahedral icosahedral JJ cord-021413-1ht1xm88 236 7 in in IN cord-021413-1ht1xm88 236 8 shape shape NN cord-021413-1ht1xm88 236 9 , , , cord-021413-1ht1xm88 236 10 with with IN cord-021413-1ht1xm88 236 11 5:3:2 5:3:2 CD cord-021413-1ht1xm88 236 12 symmetry symmetry NN cord-021413-1ht1xm88 236 13 . . . cord-021413-1ht1xm88 237 1 Particles particle NNS cord-021413-1ht1xm88 237 2 have have VBP cord-021413-1ht1xm88 237 3 a a DT cord-021413-1ht1xm88 237 4 core core NN cord-021413-1ht1xm88 237 5 , , , cord-021413-1ht1xm88 237 6 an an DT cord-021413-1ht1xm88 237 7 inner inner JJ cord-021413-1ht1xm88 237 8 layer layer NN cord-021413-1ht1xm88 237 9 or or CC cord-021413-1ht1xm88 237 10 shell shell NN cord-021413-1ht1xm88 237 11 containing contain VBG cord-021413-1ht1xm88 237 12 a a DT cord-021413-1ht1xm88 237 13 n n NN cord-021413-1ht1xm88 237 14 u u NNP cord-021413-1ht1xm88 237 15 m m NN cord-021413-1ht1xm88 237 16 b b NN cord-021413-1ht1xm88 237 17 e e NN cord-021413-1ht1xm88 237 18 r r NN cord-021413-1ht1xm88 237 19 of of IN cord-021413-1ht1xm88 237 20 capsomers capsomer NNS cord-021413-1ht1xm88 237 21 formalin formalin NN cord-021413-1ht1xm88 237 22 at at IN cord-021413-1ht1xm88 237 23 56 56 CD cord-021413-1ht1xm88 237 24 ° ° NN cord-021413-1ht1xm88 237 25 C c NN cord-021413-1ht1xm88 237 26 . . . cord-021413-1ht1xm88 238 1 Ether ether NN cord-021413-1ht1xm88 238 2 treatment treatment NN cord-021413-1ht1xm88 238 3 was be VBD cord-021413-1ht1xm88 238 4 ineffective ineffective JJ cord-021413-1ht1xm88 238 5 . . . cord-021413-1ht1xm88 239 1 Rozee Rozee NNP cord-021413-1ht1xm88 239 2 and and CC cord-021413-1ht1xm88 239 3 Leers Leers NNP cord-021413-1ht1xm88 239 4 ( ( -LRB- cord-021413-1ht1xm88 239 5 1967 1967 CD cord-021413-1ht1xm88 239 6 ) ) -RRB- cord-021413-1ht1xm88 239 7 determined determine VBD cord-021413-1ht1xm88 239 8 that that IN cord-021413-1ht1xm88 239 9 although although IN cord-021413-1ht1xm88 239 10 cholorform cholorform NNP cord-021413-1ht1xm88 239 11 does do VBZ cord-021413-1ht1xm88 239 12 not not RB cord-021413-1ht1xm88 239 13 affect affect VB cord-021413-1ht1xm88 239 14 infectivity infectivity NN cord-021413-1ht1xm88 239 15 , , , cord-021413-1ht1xm88 239 16 it -PRON- PRP cord-021413-1ht1xm88 239 17 does do VBZ cord-021413-1ht1xm88 239 18 destroy destroy VB cord-021413-1ht1xm88 239 19 the the DT cord-021413-1ht1xm88 239 20 hemagglutinin hemagglutinin NN cord-021413-1ht1xm88 239 21 . . . cord-021413-1ht1xm88 240 1 Wallis Wallis NNP cord-021413-1ht1xm88 240 2 et et NNP cord-021413-1ht1xm88 240 3 al al NNP cord-021413-1ht1xm88 240 4 . . . cord-021413-1ht1xm88 241 1 ( ( -LRB- cord-021413-1ht1xm88 241 2 1964 1964 CD cord-021413-1ht1xm88 241 3 ) ) -RRB- cord-021413-1ht1xm88 241 4 found find VBD cord-021413-1ht1xm88 241 5 that that IN cord-021413-1ht1xm88 241 6 Mg^^ Mg^^ NNP cord-021413-1ht1xm88 241 7 enhances enhance VBZ cord-021413-1ht1xm88 241 8 the the DT cord-021413-1ht1xm88 241 9 titer titer NN cord-021413-1ht1xm88 241 10 of of IN cord-021413-1ht1xm88 241 11 reovirus reovirus NNP cord-021413-1ht1xm88 241 12 at at IN cord-021413-1ht1xm88 241 13 50 50 CD cord-021413-1ht1xm88 241 14 ° ° NN cord-021413-1ht1xm88 241 15 C c NN cord-021413-1ht1xm88 241 16 . . . cord-021413-1ht1xm88 242 1 The the DT cord-021413-1ht1xm88 242 2 infective infective JJ cord-021413-1ht1xm88 242 3 titer titer NN cord-021413-1ht1xm88 242 4 increased increase VBD cord-021413-1ht1xm88 242 5 four four CD cord-021413-1ht1xm88 242 6 to to TO cord-021413-1ht1xm88 242 7 eight eight CD cord-021413-1ht1xm88 242 8 times time NNS cord-021413-1ht1xm88 242 9 by by IN cord-021413-1ht1xm88 242 10 heat heat NN cord-021413-1ht1xm88 242 11 ing ing NN cord-021413-1ht1xm88 242 12 for for IN cord-021413-1ht1xm88 242 13 5 5 CD cord-021413-1ht1xm88 242 14 - - SYM cord-021413-1ht1xm88 242 15 15 15 CD cord-021413-1ht1xm88 242 16 min min NN cord-021413-1ht1xm88 242 17 in in IN cord-021413-1ht1xm88 242 18 2 2 CD cord-021413-1ht1xm88 242 19 Μ μ NN cord-021413-1ht1xm88 242 20 MgCl2 mgcl2 NN cord-021413-1ht1xm88 242 21 . . . cord-021413-1ht1xm88 243 1 Other other JJ cord-021413-1ht1xm88 243 2 divalent divalent JJ cord-021413-1ht1xm88 243 3 cations cation NNS cord-021413-1ht1xm88 243 4 and and CC cord-021413-1ht1xm88 243 5 NaCl nacl NN cord-021413-1ht1xm88 243 6 were be VBD cord-021413-1ht1xm88 243 7 ineffective ineffective JJ cord-021413-1ht1xm88 243 8 . . . cord-021413-1ht1xm88 244 1 Hemagglutinin Hemagglutinin NNP cord-021413-1ht1xm88 244 2 was be VBD cord-021413-1ht1xm88 244 3 not not RB cord-021413-1ht1xm88 244 4 affected affect VBN cord-021413-1ht1xm88 244 5 . . . cord-021413-1ht1xm88 245 1 It -PRON- PRP cord-021413-1ht1xm88 245 2 is be VBZ cord-021413-1ht1xm88 245 3 thought think VBN cord-021413-1ht1xm88 245 4 that that IN cord-021413-1ht1xm88 245 5 the the DT cord-021413-1ht1xm88 245 6 high high JJ cord-021413-1ht1xm88 245 7 temperature temperature NN cord-021413-1ht1xm88 245 8 and and CC cord-021413-1ht1xm88 245 9 Mg^+ mg^+ DT cord-021413-1ht1xm88 245 10 caused cause VBN cord-021413-1ht1xm88 245 11 activation activation NN cord-021413-1ht1xm88 245 12 of of IN cord-021413-1ht1xm88 245 13 reovirus reovirus NNP cord-021413-1ht1xm88 245 14 particles particle NNS cord-021413-1ht1xm88 245 15 that that WDT cord-021413-1ht1xm88 245 16 were be VBD cord-021413-1ht1xm88 245 17 inactive inactive JJ cord-021413-1ht1xm88 245 18 in in IN cord-021413-1ht1xm88 245 19 the the DT cord-021413-1ht1xm88 245 20 original original JJ cord-021413-1ht1xm88 245 21 prepa prepa JJ cord-021413-1ht1xm88 245 22 rations ration NNS cord-021413-1ht1xm88 245 23 . . . cord-021413-1ht1xm88 246 1 As as IN cord-021413-1ht1xm88 246 2 with with IN cord-021413-1ht1xm88 246 3 rotavirus rotavirus NN cord-021413-1ht1xm88 246 4 . . . cord-021413-1ht1xm88 247 1 Ward Ward NNP cord-021413-1ht1xm88 247 2 and and CC cord-021413-1ht1xm88 247 3 Ashley Ashley NNP cord-021413-1ht1xm88 247 4 ( ( -LRB- cord-021413-1ht1xm88 247 5 1978 1978 CD cord-021413-1ht1xm88 247 6 ) ) -RRB- cord-021413-1ht1xm88 247 7 found find VBD cord-021413-1ht1xm88 247 8 that that IN cord-021413-1ht1xm88 247 9 reovirus reovirus NNP cord-021413-1ht1xm88 247 10 was be VBD cord-021413-1ht1xm88 247 11 sensitive sensitive JJ cord-021413-1ht1xm88 247 12 to to IN cord-021413-1ht1xm88 247 13 anionic anionic JJ cord-021413-1ht1xm88 247 14 detergents detergent NNS cord-021413-1ht1xm88 247 15 in in IN cord-021413-1ht1xm88 247 16 wastewater wastewater NN cord-021413-1ht1xm88 247 17 sludge sludge NN cord-021413-1ht1xm88 248 1 , , , cord-021413-1ht1xm88 248 2 i.e. i.e. FW cord-021413-1ht1xm88 248 3 , , , cord-021413-1ht1xm88 248 4 these these DT cord-021413-1ht1xm88 248 5 chemicals chemical NNS cord-021413-1ht1xm88 248 6 decreased decrease VBD cord-021413-1ht1xm88 248 7 the the DT cord-021413-1ht1xm88 248 8 temperature temperature NN cord-021413-1ht1xm88 248 9 needed need VBN cord-021413-1ht1xm88 248 10 to to TO cord-021413-1ht1xm88 248 11 inactivate inactivate VB cord-021413-1ht1xm88 248 12 the the DT cord-021413-1ht1xm88 248 13 virus virus NN cord-021413-1ht1xm88 248 14 . . . cord-021413-1ht1xm88 249 1 Cationic Cationic NNP cord-021413-1ht1xm88 249 2 detergents detergent NNS cord-021413-1ht1xm88 249 3 were be VBD cord-021413-1ht1xm88 249 4 more more RBR cord-021413-1ht1xm88 249 5 active active JJ cord-021413-1ht1xm88 249 6 than than IN cord-021413-1ht1xm88 249 7 anionic anionic JJ cord-021413-1ht1xm88 249 8 , , , cord-021413-1ht1xm88 249 9 and and CC cord-021413-1ht1xm88 249 10 nonionic nonionic JJ cord-021413-1ht1xm88 249 11 detergents detergent NNS cord-021413-1ht1xm88 249 12 were be VBD cord-021413-1ht1xm88 249 13 inactive inactive JJ cord-021413-1ht1xm88 249 14 in in IN cord-021413-1ht1xm88 249 15 decreas decreas NNP cord-021413-1ht1xm88 249 16 ing ing NNP cord-021413-1ht1xm88 249 17 reovirus reovirus NNP cord-021413-1ht1xm88 249 18 thermal thermal JJ cord-021413-1ht1xm88 249 19 stability stability NN cord-021413-1ht1xm88 249 20 . . . cord-021413-1ht1xm88 250 1 Mutagens mutagen NNS cord-021413-1ht1xm88 250 2 ( ( -LRB- cord-021413-1ht1xm88 250 3 nitrous nitrous JJ cord-021413-1ht1xm88 250 4 acid acid NN cord-021413-1ht1xm88 250 5 , , , cord-021413-1ht1xm88 250 6 nitrosoguanidine nitrosoguanidine NN cord-021413-1ht1xm88 250 7 , , , cord-021413-1ht1xm88 250 8 and and CC cord-021413-1ht1xm88 250 9 proflavine proflavine NN cord-021413-1ht1xm88 250 10 ) ) -RRB- cord-021413-1ht1xm88 250 11 have have VBP cord-021413-1ht1xm88 250 12 been be VBN cord-021413-1ht1xm88 250 13 applied apply VBN cord-021413-1ht1xm88 250 14 to to IN cord-021413-1ht1xm88 250 15 reovirus reovirus NNP cord-021413-1ht1xm88 250 16 3 3 CD cord-021413-1ht1xm88 250 17 ( ( -LRB- cord-021413-1ht1xm88 250 18 Fields field NNS cord-021413-1ht1xm88 250 19 and and CC cord-021413-1ht1xm88 250 20 Joklik Joklik NNP cord-021413-1ht1xm88 250 21 , , , cord-021413-1ht1xm88 250 22 1969 1969 CD cord-021413-1ht1xm88 250 23 ) ) -RRB- cord-021413-1ht1xm88 250 24 . . . cord-021413-1ht1xm88 251 1 The the DT cord-021413-1ht1xm88 251 2 resulting result VBG cord-021413-1ht1xm88 251 3 mutants mutant NNS cord-021413-1ht1xm88 251 4 are be VBP cord-021413-1ht1xm88 251 5 of of IN cord-021413-1ht1xm88 251 6 interest interest NN cord-021413-1ht1xm88 251 7 not not RB cord-021413-1ht1xm88 251 8 only only RB cord-021413-1ht1xm88 251 9 to to IN cord-021413-1ht1xm88 251 10 the the DT cord-021413-1ht1xm88 251 11 molecular molecular JJ cord-021413-1ht1xm88 251 12 biologist biologist NN cord-021413-1ht1xm88 251 13 but but CC cord-021413-1ht1xm88 251 14 to to IN cord-021413-1ht1xm88 251 15 the the DT cord-021413-1ht1xm88 251 16 clinical clinical JJ cord-021413-1ht1xm88 251 17 virologist virologist NN cord-021413-1ht1xm88 251 18 as as RB cord-021413-1ht1xm88 251 19 well well RB cord-021413-1ht1xm88 251 20 , , , cord-021413-1ht1xm88 251 21 since since IN cord-021413-1ht1xm88 251 22 some some DT cord-021413-1ht1xm88 251 23 of of IN cord-021413-1ht1xm88 251 24 them -PRON- PRP cord-021413-1ht1xm88 251 25 produce produce VBP cord-021413-1ht1xm88 251 26 altered alter VBN cord-021413-1ht1xm88 251 27 disease disease NN cord-021413-1ht1xm88 251 28 pictures picture NNS cord-021413-1ht1xm88 251 29 ( ( -LRB- cord-021413-1ht1xm88 251 30 Fields Fields NNP cord-021413-1ht1xm88 251 31 and and CC cord-021413-1ht1xm88 251 32 Raine Raine NNP cord-021413-1ht1xm88 251 33 , , , cord-021413-1ht1xm88 251 34 1972 1972 CD cord-021413-1ht1xm88 251 35 ) ) -RRB- cord-021413-1ht1xm88 251 36 . . . cord-021413-1ht1xm88 252 1 For for IN cord-021413-1ht1xm88 252 2 example example NN cord-021413-1ht1xm88 252 3 , , , cord-021413-1ht1xm88 252 4 when when WRB cord-021413-1ht1xm88 252 5 inoculated inoculate VBN cord-021413-1ht1xm88 252 6 into into IN cord-021413-1ht1xm88 252 7 rats rat NNS cord-021413-1ht1xm88 252 8 , , , cord-021413-1ht1xm88 252 9 wild wild JJ cord-021413-1ht1xm88 252 10 - - HYPH cord-021413-1ht1xm88 252 11 type type NN cord-021413-1ht1xm88 252 12 virus virus NN cord-021413-1ht1xm88 252 13 produced produce VBD cord-021413-1ht1xm88 252 14 a a DT cord-021413-1ht1xm88 252 15 necrotizing necrotize VBG cord-021413-1ht1xm88 252 16 encephalitis encephalitis RB cord-021413-1ht1xm88 252 17 , , , cord-021413-1ht1xm88 252 18 whereas whereas IN cord-021413-1ht1xm88 252 19 a a DT cord-021413-1ht1xm88 252 20 mutant mutant NN cord-021413-1ht1xm88 252 21 gave give VBD cord-021413-1ht1xm88 252 22 rise rise NN cord-021413-1ht1xm88 252 23 to to IN cord-021413-1ht1xm88 252 24 a a DT cord-021413-1ht1xm88 252 25 slowly slowly RB cord-021413-1ht1xm88 252 26 progressive progressive JJ cord-021413-1ht1xm88 252 27 communicating communicate VBG cord-021413-1ht1xm88 252 28 hydrocephalus hydrocephalus NN cord-021413-1ht1xm88 252 29 . . . cord-021413-1ht1xm88 253 1 The the DT cord-021413-1ht1xm88 253 2 effects effect NNS cord-021413-1ht1xm88 253 3 of of IN cord-021413-1ht1xm88 253 4 enzymes enzyme NNS cord-021413-1ht1xm88 253 5 are be VBP cord-021413-1ht1xm88 253 6 described describe VBN cord-021413-1ht1xm88 253 7 below below IN cord-021413-1ht1xm88 253 8 ( ( -LRB- cord-021413-1ht1xm88 253 9 see see VB cord-021413-1ht1xm88 253 10 Section Section NNP cord-021413-1ht1xm88 253 11 III III NNP cord-021413-1ht1xm88 253 12 , , , cord-021413-1ht1xm88 253 13 B,5 B,5 NNP cord-021413-1ht1xm88 253 14 ) ) -RRB- cord-021413-1ht1xm88 253 15 . . . cord-021413-1ht1xm88 254 1 In in IN cord-021413-1ht1xm88 254 2 phosphate phosphate NN cord-021413-1ht1xm88 254 3 - - HYPH cord-021413-1ht1xm88 254 4 citrate citrate NN cord-021413-1ht1xm88 254 5 buffers buffer NNS cord-021413-1ht1xm88 254 6 , , , cord-021413-1ht1xm88 254 7 Stanley Stanley NNP cord-021413-1ht1xm88 254 8 et et NNP cord-021413-1ht1xm88 254 9 al al NNP cord-021413-1ht1xm88 254 10 . . . cord-021413-1ht1xm88 255 1 ( ( -LRB- cord-021413-1ht1xm88 255 2 1953 1953 CD cord-021413-1ht1xm88 255 3 ) ) -RRB- cord-021413-1ht1xm88 255 4 ascertained ascertain VBD cord-021413-1ht1xm88 255 5 that that IN cord-021413-1ht1xm88 255 6 the the DT cord-021413-1ht1xm88 255 7 virus virus NN cord-021413-1ht1xm88 255 8 is be VBZ cord-021413-1ht1xm88 255 9 stable stable JJ cord-021413-1ht1xm88 255 10 between between IN cord-021413-1ht1xm88 255 11 pH pH NNP cord-021413-1ht1xm88 255 12 2.2 2.2 CD cord-021413-1ht1xm88 255 13 and and CC cord-021413-1ht1xm88 255 14 8.0 8.0 CD cord-021413-1ht1xm88 255 15 . . . cord-021413-1ht1xm88 256 1 e. e. NNP cord-021413-1ht1xm88 256 2 Antigenic Antigenic NNP cord-021413-1ht1xm88 256 3 Determinants Determinants NNPS cord-021413-1ht1xm88 256 4 . . . cord-021413-1ht1xm88 257 1 Sabin Sabin NNP cord-021413-1ht1xm88 257 2 ( ( -LRB- cord-021413-1ht1xm88 257 3 1959 1959 CD cord-021413-1ht1xm88 257 4 ) ) -RRB- cord-021413-1ht1xm88 257 5 demonstrated demonstrate VBD cord-021413-1ht1xm88 257 6 that that IN cord-021413-1ht1xm88 257 7 the the DT cord-021413-1ht1xm88 257 8 mammalian mammalian JJ cord-021413-1ht1xm88 257 9 reoviruses reovirus NNS cord-021413-1ht1xm88 257 10 known know VBN cord-021413-1ht1xm88 257 11 at at IN cord-021413-1ht1xm88 257 12 that that DT cord-021413-1ht1xm88 257 13 time time NN cord-021413-1ht1xm88 257 14 could could MD cord-021413-1ht1xm88 257 15 be be VB cord-021413-1ht1xm88 257 16 divided divide VBN cord-021413-1ht1xm88 257 17 into into IN cord-021413-1ht1xm88 257 18 three three CD cord-021413-1ht1xm88 257 19 serologic serologic JJ cord-021413-1ht1xm88 257 20 groups group NNS cord-021413-1ht1xm88 257 21 by by IN cord-021413-1ht1xm88 257 22 neutralization neutralization NN cord-021413-1ht1xm88 257 23 tests test NNS cord-021413-1ht1xm88 257 24 . . . cord-021413-1ht1xm88 258 1 They -PRON- PRP cord-021413-1ht1xm88 258 2 could could MD cord-021413-1ht1xm88 258 3 also also RB cord-021413-1ht1xm88 258 4 be be VB cord-021413-1ht1xm88 258 5 differentiated differentiate VBN cord-021413-1ht1xm88 258 6 by by IN cord-021413-1ht1xm88 258 7 hemagglutination hemagglutination NN cord-021413-1ht1xm88 258 8 inhibi inhibi NNP cord-021413-1ht1xm88 258 9 tion tion NNP cord-021413-1ht1xm88 258 10 ( ( -LRB- cord-021413-1ht1xm88 258 11 Rosen Rosen NNP cord-021413-1ht1xm88 258 12 , , , cord-021413-1ht1xm88 258 13 1960 1960 CD cord-021413-1ht1xm88 258 14 ) ) -RRB- cord-021413-1ht1xm88 258 15 , , , cord-021413-1ht1xm88 258 16 Hull Hull NNP cord-021413-1ht1xm88 258 17 et et NNP cord-021413-1ht1xm88 258 18 al al NNP cord-021413-1ht1xm88 258 19 . . . cord-021413-1ht1xm88 259 1 ( ( -LRB- cord-021413-1ht1xm88 259 2 1956 1956 CD cord-021413-1ht1xm88 259 3 having have VBG cord-021413-1ht1xm88 259 4 discovered discover VBN cord-021413-1ht1xm88 259 5 that that IN cord-021413-1ht1xm88 259 6 ECHO ECHO NNP cord-021413-1ht1xm88 259 7 10 10 CD cord-021413-1ht1xm88 259 8 virus virus NN cord-021413-1ht1xm88 259 9 possessed possess VBD cord-021413-1ht1xm88 259 10 a a DT cord-021413-1ht1xm88 259 11 hemagglutinin hemagglutinin NN cord-021413-1ht1xm88 259 12 for for IN cord-021413-1ht1xm88 259 13 human human JJ cord-021413-1ht1xm88 259 14 O O NNP cord-021413-1ht1xm88 259 15 eryth eryth NN cord-021413-1ht1xm88 259 16 rocytes rocyte NNS cord-021413-1ht1xm88 259 17 . . . cord-021413-1ht1xm88 260 1 Later later RB cord-021413-1ht1xm88 260 2 , , , cord-021413-1ht1xm88 260 3 reported report VBD cord-021413-1ht1xm88 260 4 that that IN cord-021413-1ht1xm88 260 5 reovirus reovirus NNP cord-021413-1ht1xm88 260 6 3 3 CD cord-021413-1ht1xm88 260 7 , , , cord-021413-1ht1xm88 260 8 but but CC cord-021413-1ht1xm88 260 9 not not RB cord-021413-1ht1xm88 260 10 reovirus reovirus NNP cord-021413-1ht1xm88 260 11 1 1 CD cord-021413-1ht1xm88 260 12 or or CC cord-021413-1ht1xm88 260 13 2 2 CD cord-021413-1ht1xm88 260 14 , , , cord-021413-1ht1xm88 260 15 agglutinated agglutinated NNP cord-021413-1ht1xm88 260 16 ox ox NNP cord-021413-1ht1xm88 260 17 erythro erythro NNP cord-021413-1ht1xm88 260 18 cytes cytes NNP cord-021413-1ht1xm88 260 19 . . . cord-021413-1ht1xm88 261 1 The the DT cord-021413-1ht1xm88 261 2 reovirus reovirus NN cord-021413-1ht1xm88 261 3 3 3 CD cord-021413-1ht1xm88 261 4 hemagglutinin hemagglutinin NN cord-021413-1ht1xm88 261 5 was be VBD cord-021413-1ht1xm88 261 6 inhibited inhibit VBN cord-021413-1ht1xm88 261 7 by by IN cord-021413-1ht1xm88 261 8 nonspecific nonspecific JJ cord-021413-1ht1xm88 261 9 substances substance NNS cord-021413-1ht1xm88 261 10 such such JJ cord-021413-1ht1xm88 261 11 as as IN cord-021413-1ht1xm88 261 12 normal normal JJ cord-021413-1ht1xm88 261 13 mouse mouse NN cord-021413-1ht1xm88 261 14 , , , cord-021413-1ht1xm88 261 15 rabbit rabbit NN cord-021413-1ht1xm88 261 16 , , , cord-021413-1ht1xm88 261 17 or or CC cord-021413-1ht1xm88 261 18 rat rat NN cord-021413-1ht1xm88 261 19 serum serum NN cord-021413-1ht1xm88 261 20 , , , cord-021413-1ht1xm88 261 21 and and CC cord-021413-1ht1xm88 261 22 by by IN cord-021413-1ht1xm88 261 23 Vibrio Vibrio NNP cord-021413-1ht1xm88 261 24 cholerae cholerae NN cord-021413-1ht1xm88 261 25 filtrate filtrate NN cord-021413-1ht1xm88 261 26 . . . cord-021413-1ht1xm88 262 1 Weiner Weiner NNP cord-021413-1ht1xm88 262 2 et et NNP cord-021413-1ht1xm88 262 3 al al NNP cord-021413-1ht1xm88 262 4 . . . cord-021413-1ht1xm88 263 1 ( ( -LRB- cord-021413-1ht1xm88 263 2 1978 1978 CD cord-021413-1ht1xm88 263 3 ) ) -RRB- cord-021413-1ht1xm88 263 4 were be VBD cord-021413-1ht1xm88 263 5 able able JJ cord-021413-1ht1xm88 263 6 to to TO cord-021413-1ht1xm88 263 7 show show VB cord-021413-1ht1xm88 263 8 that that IN cord-021413-1ht1xm88 263 9 the the DT cord-021413-1ht1xm88 263 10 57 57 CD cord-021413-1ht1xm88 263 11 RNA RNA NNP cord-021413-1ht1xm88 263 12 segment segment NN cord-021413-1ht1xm88 263 13 , , , cord-021413-1ht1xm88 263 14 which which WDT cord-021413-1ht1xm88 263 15 is be VBZ cord-021413-1ht1xm88 263 16 associated associate VBN cord-021413-1ht1xm88 263 17 with with IN cord-021413-1ht1xm88 263 18 type type NN cord-021413-1ht1xm88 263 19 specificity specificity NN cord-021413-1ht1xm88 263 20 , , , cord-021413-1ht1xm88 263 21 encodes encode VBZ cord-021413-1ht1xm88 263 22 the the DT cord-021413-1ht1xm88 263 23 polypeptide polypeptide NN cord-021413-1ht1xm88 263 24 that that WDT cord-021413-1ht1xm88 263 25 determines determine VBZ cord-021413-1ht1xm88 263 26 the the DT cord-021413-1ht1xm88 263 27 hemagglutinating hemagglutinate VBG cord-021413-1ht1xm88 263 28 properties property NNS cord-021413-1ht1xm88 263 29 of of IN cord-021413-1ht1xm88 263 30 the the DT cord-021413-1ht1xm88 263 31 virion virion NN cord-021413-1ht1xm88 263 32 . . . cord-021413-1ht1xm88 264 1 Complement complement NN cord-021413-1ht1xm88 264 2 - - HYPH cord-021413-1ht1xm88 264 3 fixing fix VBG cord-021413-1ht1xm88 264 4 antigens antigen NNS cord-021413-1ht1xm88 264 5 were be VBD cord-021413-1ht1xm88 264 6 prepared prepare VBN cord-021413-1ht1xm88 264 7 by by IN cord-021413-1ht1xm88 264 8 Stanley Stanley NNP cord-021413-1ht1xm88 264 9 et et NNP cord-021413-1ht1xm88 264 10 al al NNP cord-021413-1ht1xm88 264 11 . . . cord-021413-1ht1xm88 265 1 ( ( -LRB- cord-021413-1ht1xm88 265 2 1953 1953 CD cord-021413-1ht1xm88 265 3 , , , cord-021413-1ht1xm88 265 4 1954 1954 CD cord-021413-1ht1xm88 265 5 ) ) -RRB- cord-021413-1ht1xm88 266 1 and and CC cord-021413-1ht1xm88 266 2 by by IN cord-021413-1ht1xm88 266 3 J. J. NNP cord-021413-1ht1xm88 266 4 C. C. NNP cord-021413-1ht1xm88 266 5 Parker Parker NNP cord-021413-1ht1xm88 266 6 et et NNP cord-021413-1ht1xm88 266 7 al al NNP cord-021413-1ht1xm88 266 8 . . . cord-021413-1ht1xm88 267 1 ( ( -LRB- cord-021413-1ht1xm88 267 2 1965 1965 CD cord-021413-1ht1xm88 267 3 , , , cord-021413-1ht1xm88 267 4 1966 1966 CD cord-021413-1ht1xm88 267 5 ) ) -RRB- cord-021413-1ht1xm88 267 6 . . . cord-021413-1ht1xm88 268 1 These these DT cord-021413-1ht1xm88 268 2 are be VBP cord-021413-1ht1xm88 268 3 group group NN cord-021413-1ht1xm88 268 4 specific specific JJ cord-021413-1ht1xm88 268 5 . . . cord-021413-1ht1xm88 269 1 Leers Leers NNP cord-021413-1ht1xm88 269 2 et et NNP cord-021413-1ht1xm88 269 3 al al NNP cord-021413-1ht1xm88 269 4 . . . cord-021413-1ht1xm88 270 1 ( ( -LRB- cord-021413-1ht1xm88 270 2 1968 1968 CD cord-021413-1ht1xm88 270 3 ) ) -RRB- cord-021413-1ht1xm88 270 4 determined determine VBD cord-021413-1ht1xm88 270 5 that that IN cord-021413-1ht1xm88 270 6 reovirions reovirion NNS cord-021413-1ht1xm88 270 7 display display NN cord-021413-1ht1xm88 270 8 at at RB cord-021413-1ht1xm88 270 9 least least RBS cord-021413-1ht1xm88 270 10 one one CD cord-021413-1ht1xm88 270 11 type type NN cord-021413-1ht1xm88 270 12 - - HYPH cord-021413-1ht1xm88 270 13 specific specific JJ cord-021413-1ht1xm88 270 14 and and CC cord-021413-1ht1xm88 270 15 one one CD cord-021413-1ht1xm88 270 16 to to TO cord-021413-1ht1xm88 270 17 two two CD cord-021413-1ht1xm88 270 18 group group NN cord-021413-1ht1xm88 270 19 - - HYPH cord-021413-1ht1xm88 270 20 specific specific JJ cord-021413-1ht1xm88 270 21 antigens antigen NNS cord-021413-1ht1xm88 270 22 when when WRB cord-021413-1ht1xm88 270 23 studied study VBN cord-021413-1ht1xm88 270 24 by by IN cord-021413-1ht1xm88 270 25 immunodiffusion immunodiffusion NN cord-021413-1ht1xm88 270 26 . . . cord-021413-1ht1xm88 271 1 With with IN cord-021413-1ht1xm88 271 2 the the DT cord-021413-1ht1xm88 271 3 more more RBR cord-021413-1ht1xm88 271 4 sensitive sensitive JJ cord-021413-1ht1xm88 271 5 I -PRON- PRP cord-021413-1ht1xm88 271 6 m be VBP cord-021413-1ht1xm88 271 7 munoelectrophoresis munoelectrophoresis NN cord-021413-1ht1xm88 271 8 technique technique NN cord-021413-1ht1xm88 271 9 , , , cord-021413-1ht1xm88 271 10 however however RB cord-021413-1ht1xm88 271 11 , , , cord-021413-1ht1xm88 271 12 these these DT cord-021413-1ht1xm88 271 13 authors author NNS cord-021413-1ht1xm88 271 14 en en VBP cord-021413-1ht1xm88 271 15 countered counter VBD cord-021413-1ht1xm88 271 16 two two CD cord-021413-1ht1xm88 271 17 type type NN cord-021413-1ht1xm88 271 18 - - HYPH cord-021413-1ht1xm88 271 19 specific specific JJ cord-021413-1ht1xm88 271 20 and and CC cord-021413-1ht1xm88 271 21 four four CD cord-021413-1ht1xm88 271 22 group group NN cord-021413-1ht1xm88 271 23 - - HYPH cord-021413-1ht1xm88 271 24 specific specific JJ cord-021413-1ht1xm88 271 25 precipitin precipitin JJ cord-021413-1ht1xm88 271 26 lines line NNS cord-021413-1ht1xm88 271 27 . . . cord-021413-1ht1xm88 272 1 The the DT cord-021413-1ht1xm88 272 2 agent agent NN cord-021413-1ht1xm88 272 3 is be VBZ cord-021413-1ht1xm88 272 4 regarded regard VBN cord-021413-1ht1xm88 272 5 as as IN cord-021413-1ht1xm88 272 6 pantropic pantropic NNP cord-021413-1ht1xm88 272 7 in in IN cord-021413-1ht1xm88 272 8 mice mouse NNS cord-021413-1ht1xm88 272 9 . . . cord-021413-1ht1xm88 273 1 In in IN cord-021413-1ht1xm88 273 2 neonates neonate NNS cord-021413-1ht1xm88 273 3 , , , cord-021413-1ht1xm88 273 4 Stanley Stanley NNP cord-021413-1ht1xm88 273 5 et et NNP cord-021413-1ht1xm88 273 6 al al NNP cord-021413-1ht1xm88 273 7 . . . cord-021413-1ht1xm88 274 1 ( ( -LRB- cord-021413-1ht1xm88 274 2 1953 1953 CD cord-021413-1ht1xm88 274 3 ) ) -RRB- cord-021413-1ht1xm88 275 1 ( ( -LRB- cord-021413-1ht1xm88 275 2 Wolf Wolf NNP cord-021413-1ht1xm88 275 3 et et NNP cord-021413-1ht1xm88 275 4 al al NNP cord-021413-1ht1xm88 275 5 . . NNP cord-021413-1ht1xm88 275 6 , , , cord-021413-1ht1xm88 275 7 1981 1981 CD cord-021413-1ht1xm88 275 8 ) ) -RRB- cord-021413-1ht1xm88 275 9 . . . cord-021413-1ht1xm88 276 1 Papadimitriou Papadimitriou NNP cord-021413-1ht1xm88 276 2 ( ( -LRB- cord-021413-1ht1xm88 276 3 1965 1965 CD cord-021413-1ht1xm88 276 4 Papadimitriou Papadimitriou NNP cord-021413-1ht1xm88 276 5 ( ( -LRB- cord-021413-1ht1xm88 276 6 , , . cord-021413-1ht1xm88 277 1 1966 1966 CD cord-021413-1ht1xm88 277 2 Papadimitriou Papadimitriou NNP cord-021413-1ht1xm88 277 3 ( ( -LRB- cord-021413-1ht1xm88 277 4 , , , cord-021413-1ht1xm88 277 5 1968 1968 CD cord-021413-1ht1xm88 277 6 also also RB cord-021413-1ht1xm88 277 7 studied study VBD cord-021413-1ht1xm88 277 8 viral viral JJ cord-021413-1ht1xm88 277 9 replica replica NN cord-021413-1ht1xm88 277 10 tion tion NN cord-021413-1ht1xm88 277 11 by by IN cord-021413-1ht1xm88 277 12 electron electron NN cord-021413-1ht1xm88 277 13 microscopy microscopy NNS cord-021413-1ht1xm88 277 14 in in IN cord-021413-1ht1xm88 277 15 the the DT cord-021413-1ht1xm88 277 16 mucosa mucosa NN cord-021413-1ht1xm88 277 17 of of IN cord-021413-1ht1xm88 277 18 the the DT cord-021413-1ht1xm88 277 19 common common JJ cord-021413-1ht1xm88 277 20 bile bile NN cord-021413-1ht1xm88 277 21 duct duct NN cord-021413-1ht1xm88 277 22 and and CC cord-021413-1ht1xm88 277 23 in in IN cord-021413-1ht1xm88 277 24 the the DT cord-021413-1ht1xm88 277 25 liver liver NN cord-021413-1ht1xm88 277 26 . . . cord-021413-1ht1xm88 278 1 Reovirus Reovirus NNP cord-021413-1ht1xm88 278 2 3 3 CD cord-021413-1ht1xm88 278 3 has have VBZ cord-021413-1ht1xm88 278 4 been be VBN cord-021413-1ht1xm88 278 5 reported report VBN cord-021413-1ht1xm88 278 6 to to TO cord-021413-1ht1xm88 278 7 be be VB cord-021413-1ht1xm88 278 8 oncolytic oncolytic JJ cord-021413-1ht1xm88 278 9 for for IN cord-021413-1ht1xm88 278 10 a a DT cord-021413-1ht1xm88 278 11 mouse mouse NN cord-021413-1ht1xm88 278 12 ascites ascites NN cord-021413-1ht1xm88 278 13 tumor tumor NN cord-021413-1ht1xm88 278 14 by by IN cord-021413-1ht1xm88 278 15 Bennette Bennette NNP cord-021413-1ht1xm88 278 16 ( ( -LRB- cord-021413-1ht1xm88 278 17 1960 1960 CD cord-021413-1ht1xm88 278 18 ) ) -RRB- cord-021413-1ht1xm88 278 19 , , , cord-021413-1ht1xm88 278 20 Bennette Bennette NNP cord-021413-1ht1xm88 278 21 et et NNP cord-021413-1ht1xm88 278 22 al al NNP cord-021413-1ht1xm88 278 23 . . . cord-021413-1ht1xm88 279 1 ( ( -LRB- cord-021413-1ht1xm88 279 2 1967,a 1967,a CD cord-021413-1ht1xm88 279 3 , , , cord-021413-1ht1xm88 279 4 b b LS cord-021413-1ht1xm88 279 5 ) ) -RRB- cord-021413-1ht1xm88 279 6 , , , cord-021413-1ht1xm88 279 7 and and CC cord-021413-1ht1xm88 279 8 Nelson Nelson NNP cord-021413-1ht1xm88 279 9 and and CC cord-021413-1ht1xm88 279 10 Tamowski Tamowski NNP cord-021413-1ht1xm88 279 11 ( ( -LRB- cord-021413-1ht1xm88 279 12 1960 1960 CD cord-021413-1ht1xm88 279 13 ) ) -RRB- cord-021413-1ht1xm88 279 14 . . . cord-021413-1ht1xm88 280 1 Most Most JJS cord-021413-1ht1xm88 280 2 of of IN cord-021413-1ht1xm88 280 3 the the DT cord-021413-1ht1xm88 280 4 studies study NNS cord-021413-1ht1xm88 280 5 dealing deal VBG cord-021413-1ht1xm88 280 6 with with IN cord-021413-1ht1xm88 280 7 replication replication NN cord-021413-1ht1xm88 280 8 of of IN cord-021413-1ht1xm88 280 9 the the DT cord-021413-1ht1xm88 280 10 reoviruses reovirus NNS cord-021413-1ht1xm88 280 11 have have VBP cord-021413-1ht1xm88 280 12 been be VBN cord-021413-1ht1xm88 280 13 accomplished accomplish VBN cord-021413-1ht1xm88 280 14 in in IN cord-021413-1ht1xm88 280 15 tissue tissue NN cord-021413-1ht1xm88 280 16 culture culture NN cord-021413-1ht1xm88 280 17 , , , cord-021413-1ht1xm88 280 18 frequently frequently RB cord-021413-1ht1xm88 280 19 in in IN cord-021413-1ht1xm88 280 20 plaque plaque NN cord-021413-1ht1xm88 280 21 assays assay NNS cord-021413-1ht1xm88 280 22 in in IN cord-021413-1ht1xm88 280 23 L l NN cord-021413-1ht1xm88 280 24 - - HYPH cord-021413-1ht1xm88 280 25 cell cell NN cord-021413-1ht1xm88 280 26 monolayers monolayer NNS cord-021413-1ht1xm88 280 27 . . . cord-021413-1ht1xm88 281 1 Other other JJ cord-021413-1ht1xm88 281 2 cells cell NNS cord-021413-1ht1xm88 281 3 that that WDT cord-021413-1ht1xm88 281 4 have have VBP cord-021413-1ht1xm88 281 5 been be VBN cord-021413-1ht1xm88 281 6 suc suc NNP cord-021413-1ht1xm88 281 7 cessfully cessfully RB cord-021413-1ht1xm88 281 8 employed employ VBN cord-021413-1ht1xm88 281 9 are be VBP cord-021413-1ht1xm88 281 10 primary primary JJ cord-021413-1ht1xm88 281 11 kidney kidney NN cord-021413-1ht1xm88 281 12 monolayers monolayer NNS cord-021413-1ht1xm88 281 13 of of IN cord-021413-1ht1xm88 281 14 rhesus rhesu NNS cord-021413-1ht1xm88 281 15 , , , cord-021413-1ht1xm88 281 16 patas patas NNP cord-021413-1ht1xm88 281 17 , , , cord-021413-1ht1xm88 281 18 and and CC cord-021413-1ht1xm88 281 19 capuchin capuchin NNP cord-021413-1ht1xm88 281 20 monkeys monkey NNS cord-021413-1ht1xm88 281 21 , , , cord-021413-1ht1xm88 281 22 as as RB cord-021413-1ht1xm88 281 23 well well RB cord-021413-1ht1xm88 281 24 as as IN cord-021413-1ht1xm88 281 25 those those DT cord-021413-1ht1xm88 281 26 of of IN cord-021413-1ht1xm88 281 27 pigs pig NNS cord-021413-1ht1xm88 281 28 , , , cord-021413-1ht1xm88 281 29 cats cat NNS cord-021413-1ht1xm88 281 30 , , , cord-021413-1ht1xm88 281 31 and and CC cord-021413-1ht1xm88 281 32 dogs dog NNS cord-021413-1ht1xm88 281 33 . . . cord-021413-1ht1xm88 282 1 Continuous continuous JJ cord-021413-1ht1xm88 282 2 lines line NNS cord-021413-1ht1xm88 282 3 , , , cord-021413-1ht1xm88 282 4 such such JJ cord-021413-1ht1xm88 282 5 as as IN cord-021413-1ht1xm88 282 6 FL FL NNP cord-021413-1ht1xm88 282 7 human human JJ cord-021413-1ht1xm88 282 8 amnion amnion NN cord-021413-1ht1xm88 282 9 , , , cord-021413-1ht1xm88 282 10 BS BS NNP cord-021413-1ht1xm88 282 11 - - HYPH cord-021413-1ht1xm88 282 12 C-1 C-1 NNP cord-021413-1ht1xm88 282 13 , , , cord-021413-1ht1xm88 282 14 and and CC cord-021413-1ht1xm88 282 15 KB KB NNP cord-021413-1ht1xm88 282 16 , , , cord-021413-1ht1xm88 282 17 have have VBP cord-021413-1ht1xm88 282 18 also also RB cord-021413-1ht1xm88 282 19 been be VBN cord-021413-1ht1xm88 282 20 used use VBN cord-021413-1ht1xm88 282 21 ( ( -LRB- cord-021413-1ht1xm88 282 22 Hsiung Hsiung NNP cord-021413-1ht1xm88 282 23 , , , cord-021413-1ht1xm88 282 24 1958 1958 CD cord-021413-1ht1xm88 282 25 ; ; : cord-021413-1ht1xm88 282 26 Cook Cook NNP cord-021413-1ht1xm88 282 27 , , , cord-021413-1ht1xm88 282 28 1963 1963 CD cord-021413-1ht1xm88 282 29 ; ; : cord-021413-1ht1xm88 282 30 McClain McClain NNP cord-021413-1ht1xm88 282 31 etal etal NNP cord-021413-1ht1xm88 282 32 . . NNP cord-021413-1ht1xm88 282 33 , , , cord-021413-1ht1xm88 282 34 1967 1967 CD cord-021413-1ht1xm88 282 35 ; ; . cord-021413-1ht1xm88 283 1 Rhim Rhim NNP cord-021413-1ht1xm88 283 2 and and CC cord-021413-1ht1xm88 283 3 Melnick Melnick NNP cord-021413-1ht1xm88 283 4 , , , cord-021413-1ht1xm88 283 5 1961 1961 CD cord-021413-1ht1xm88 283 6 ; ; : cord-021413-1ht1xm88 283 7 Harford Harford NNP cord-021413-1ht1xm88 283 8 et et NNP cord-021413-1ht1xm88 283 9 al al NNP cord-021413-1ht1xm88 283 10 . . NNP cord-021413-1ht1xm88 283 11 , , , cord-021413-1ht1xm88 283 12 1962 1962 CD cord-021413-1ht1xm88 283 13 ) ) -RRB- cord-021413-1ht1xm88 283 14 . . . cord-021413-1ht1xm88 284 1 Harford Harford NNP cord-021413-1ht1xm88 284 2 et et NNP cord-021413-1ht1xm88 284 3 al al NNP cord-021413-1ht1xm88 284 4 . . . cord-021413-1ht1xm88 285 1 ( ( -LRB- cord-021413-1ht1xm88 285 2 1962 1962 CD cord-021413-1ht1xm88 285 3 ) ) -RRB- cord-021413-1ht1xm88 286 1 ( ( -LRB- cord-021413-1ht1xm88 286 2 1973a 1973a CD cord-021413-1ht1xm88 286 3 , , , cord-021413-1ht1xm88 286 4 b b NN cord-021413-1ht1xm88 286 5 , , , cord-021413-1ht1xm88 286 6 c c NNP cord-021413-1ht1xm88 286 7 , , , cord-021413-1ht1xm88 286 8 1974 1974 CD cord-021413-1ht1xm88 286 9 , , , cord-021413-1ht1xm88 286 10 1979 1979 CD cord-021413-1ht1xm88 286 11 ) ) -RRB- cord-021413-1ht1xm88 286 12 . . . cord-021413-1ht1xm88 287 1 Stanley Stanley NNP cord-021413-1ht1xm88 287 2 et et NNP cord-021413-1ht1xm88 287 3 al al NNP cord-021413-1ht1xm88 287 4 . . . cord-021413-1ht1xm88 288 1 ( ( -LRB- cord-021413-1ht1xm88 288 2 1953 1953 CD cord-021413-1ht1xm88 288 3 , , , cord-021413-1ht1xm88 288 4 1954 1954 CD cord-021413-1ht1xm88 288 5 ) ) -RRB- cord-021413-1ht1xm88 288 6 reported report VBD cord-021413-1ht1xm88 288 7 the the DT cord-021413-1ht1xm88 288 8 development development NN cord-021413-1ht1xm88 288 9 of of IN cord-021413-1ht1xm88 288 10 pocks pock NNS cord-021413-1ht1xm88 288 11 on on IN cord-021413-1ht1xm88 288 12 the the DT cord-021413-1ht1xm88 288 13 chorioallantois chorioallantois NN cord-021413-1ht1xm88 288 14 of of IN cord-021413-1ht1xm88 288 15 12-day 12-day CD cord-021413-1ht1xm88 288 16 - - HYPH cord-021413-1ht1xm88 288 17 old old JJ cord-021413-1ht1xm88 288 18 chick chick NN cord-021413-1ht1xm88 288 19 embryos embryo NNS cord-021413-1ht1xm88 288 20 in in IN cord-021413-1ht1xm88 288 21 oculated oculate VBN cord-021413-1ht1xm88 288 22 with with IN cord-021413-1ht1xm88 288 23 infectious infectious JJ cord-021413-1ht1xm88 288 24 brain brain NN cord-021413-1ht1xm88 288 25 and and CC cord-021413-1ht1xm88 288 26 liver liver NN cord-021413-1ht1xm88 288 27 . . . cord-021413-1ht1xm88 289 1 The the DT cord-021413-1ht1xm88 289 2 embryos embryo NNS cord-021413-1ht1xm88 289 3 appeared appear VBD cord-021413-1ht1xm88 289 4 unaffected unaffected JJ cord-021413-1ht1xm88 289 5 , , , cord-021413-1ht1xm88 289 6 and and CC cord-021413-1ht1xm88 289 7 with with IN cord-021413-1ht1xm88 289 8 succeeding succeed VBG cord-021413-1ht1xm88 289 9 passages passage NNS cord-021413-1ht1xm88 289 10 , , , cord-021413-1ht1xm88 289 11 the the DT cord-021413-1ht1xm88 289 12 pocks pock NNS cord-021413-1ht1xm88 289 13 could could MD cord-021413-1ht1xm88 289 14 no no RB cord-021413-1ht1xm88 289 15 longer longer RB cord-021413-1ht1xm88 289 16 be be VB cord-021413-1ht1xm88 289 17 observed observe VBN cord-021413-1ht1xm88 289 18 , , , cord-021413-1ht1xm88 289 19 although although IN cord-021413-1ht1xm88 289 20 oral oral JJ cord-021413-1ht1xm88 289 21 inoculation inoculation NN cord-021413-1ht1xm88 289 22 of of IN cord-021413-1ht1xm88 289 23 suckling suckle VBG cord-021413-1ht1xm88 289 24 mice mouse NNS cord-021413-1ht1xm88 289 25 with with IN cord-021413-1ht1xm88 289 26 chorioallantoic chorioallantoic NNP cord-021413-1ht1xm88 289 27 suspensions suspension NNS cord-021413-1ht1xm88 289 28 resulted result VBD cord-021413-1ht1xm88 289 29 in in IN cord-021413-1ht1xm88 289 30 active active JJ cord-021413-1ht1xm88 289 31 disease disease NN cord-021413-1ht1xm88 289 32 . . . cord-021413-1ht1xm88 290 1 Essentially essentially RB cord-021413-1ht1xm88 290 2 the the DT cord-021413-1ht1xm88 290 3 same same JJ cord-021413-1ht1xm88 290 4 results result NNS cord-021413-1ht1xm88 290 5 were be VBD cord-021413-1ht1xm88 290 6 found find VBN cord-021413-1ht1xm88 290 7 following follow VBG cord-021413-1ht1xm88 290 8 amniotic amniotic NN cord-021413-1ht1xm88 290 9 inoculation inoculation NN cord-021413-1ht1xm88 290 10 . . . cord-021413-1ht1xm88 291 1 The the DT cord-021413-1ht1xm88 291 2 experimental experimental JJ cord-021413-1ht1xm88 291 3 and and CC cord-021413-1ht1xm88 291 4 natural natural JJ cord-021413-1ht1xm88 291 5 diseases disease NNS cord-021413-1ht1xm88 291 6 appear appear VBP cord-021413-1ht1xm88 291 7 identical identical JJ cord-021413-1ht1xm88 291 8 ex ex FW cord-021413-1ht1xm88 291 9 cept cept NN cord-021413-1ht1xm88 291 10 for for IN cord-021413-1ht1xm88 291 11 variations variation NNS cord-021413-1ht1xm88 291 12 in in IN cord-021413-1ht1xm88 291 13 intensity intensity NN cord-021413-1ht1xm88 291 14 of of IN cord-021413-1ht1xm88 291 15 signs sign NNS cord-021413-1ht1xm88 291 16 , , , cord-021413-1ht1xm88 291 17 perhaps perhaps RB cord-021413-1ht1xm88 291 18 due due IN cord-021413-1ht1xm88 291 19 to to IN cord-021413-1ht1xm88 291 20 dif dif VB cord-021413-1ht1xm88 291 21 ferences ference NNS cord-021413-1ht1xm88 291 22 in in IN cord-021413-1ht1xm88 291 23 infectious infectious JJ cord-021413-1ht1xm88 291 24 dose dose NN cord-021413-1ht1xm88 291 25 . . . cord-021413-1ht1xm88 292 1 Up up IN cord-021413-1ht1xm88 292 2 to to TO cord-021413-1ht1xm88 292 3 16 16 CD cord-021413-1ht1xm88 292 4 days day NNS cord-021413-1ht1xm88 292 5 after after IN cord-021413-1ht1xm88 292 6 intraperitoneal intraperitoneal JJ cord-021413-1ht1xm88 292 7 inoculation inoculation NN cord-021413-1ht1xm88 292 8 , , , cord-021413-1ht1xm88 292 9 the the DT cord-021413-1ht1xm88 292 10 mice mouse NNS cord-021413-1ht1xm88 292 11 appear appear VBP cord-021413-1ht1xm88 292 12 emaciated emaciated JJ cord-021413-1ht1xm88 292 13 and and CC cord-021413-1ht1xm88 292 14 uncoordinated uncoordinated JJ cord-021413-1ht1xm88 292 15 . . . cord-021413-1ht1xm88 293 1 The the DT cord-021413-1ht1xm88 293 2 hair hair NN cord-021413-1ht1xm88 293 3 is be VBZ cord-021413-1ht1xm88 293 4 oily oily JJ cord-021413-1ht1xm88 293 5 and and CC cord-021413-1ht1xm88 293 6 matted mat VBN cord-021413-1ht1xm88 293 7 - - : cord-021413-1ht1xm88 293 8 the the DT cord-021413-1ht1xm88 293 9 so so RB cord-021413-1ht1xm88 293 10 - - HYPH cord-021413-1ht1xm88 293 11 called call VBN cord-021413-1ht1xm88 293 12 oily oily JJ cord-021413-1ht1xm88 293 13 hair hair NN cord-021413-1ht1xm88 293 14 effect effect NN cord-021413-1ht1xm88 293 15 ( ( -LRB- cord-021413-1ht1xm88 293 16 OHE)-an OHE)-an `` cord-021413-1ht1xm88 293 17 effect effect NN cord-021413-1ht1xm88 293 18 that that WDT cord-021413-1ht1xm88 293 19 can can MD cord-021413-1ht1xm88 293 20 be be VB cord-021413-1ht1xm88 293 21 demonstrated demonstrate VBN cord-021413-1ht1xm88 293 22 in in IN cord-021413-1ht1xm88 293 23 contact contact NN cord-021413-1ht1xm88 293 24 animáis animáis NNP cord-021413-1ht1xm88 293 25 as as RB cord-021413-1ht1xm88 293 26 well well RB cord-021413-1ht1xm88 293 27 . . . cord-021413-1ht1xm88 294 1 However however RB cord-021413-1ht1xm88 294 2 , , , cord-021413-1ht1xm88 294 3 in in IN cord-021413-1ht1xm88 294 4 these these DT cord-021413-1ht1xm88 294 5 mice mouse NNS cord-021413-1ht1xm88 294 6 it -PRON- PRP cord-021413-1ht1xm88 294 7 disappears disappear VBZ cord-021413-1ht1xm88 294 8 as as RB cord-021413-1ht1xm88 294 9 soon soon RB cord-021413-1ht1xm88 294 10 as as IN cord-021413-1ht1xm88 294 11 the the DT cord-021413-1ht1xm88 294 12 diseased diseased JJ cord-021413-1ht1xm88 294 13 animal animal NN cord-021413-1ht1xm88 294 14 is be VBZ cord-021413-1ht1xm88 294 15 removed remove VBN cord-021413-1ht1xm88 294 16 from from IN cord-021413-1ht1xm88 294 17 the the DT cord-021413-1ht1xm88 294 18 healthy healthy JJ cord-021413-1ht1xm88 294 19 ones one NNS cord-021413-1ht1xm88 294 20 . . . cord-021413-1ht1xm88 295 1 The the DT cord-021413-1ht1xm88 295 2 effect effect NN cord-021413-1ht1xm88 295 3 was be VBD cord-021413-1ht1xm88 295 4 ultimately ultimately RB cord-021413-1ht1xm88 295 5 traced trace VBN cord-021413-1ht1xm88 295 6 to to IN cord-021413-1ht1xm88 295 7 a a DT cord-021413-1ht1xm88 295 8 high high JJ cord-021413-1ht1xm88 295 9 proportion proportion NN cord-021413-1ht1xm88 295 10 of of IN cord-021413-1ht1xm88 295 11 fat fat NN cord-021413-1ht1xm88 295 12 in in IN cord-021413-1ht1xm88 295 13 the the DT cord-021413-1ht1xm88 295 14 intesti intesti NNP cord-021413-1ht1xm88 295 15 nal nal FW cord-021413-1ht1xm88 295 16 contents content NNS cord-021413-1ht1xm88 295 17 ( ( -LRB- cord-021413-1ht1xm88 295 18 steatorrhea steatorrhea NNP cord-021413-1ht1xm88 295 19 ) ) -RRB- cord-021413-1ht1xm88 295 20 : : : cord-021413-1ht1xm88 295 21 12.9 12.9 CD cord-021413-1ht1xm88 295 22 % % NN cord-021413-1ht1xm88 295 23 in in IN cord-021413-1ht1xm88 295 24 infected infected JJ cord-021413-1ht1xm88 295 25 animals animal NNS cord-021413-1ht1xm88 295 26 as as IN cord-021413-1ht1xm88 295 27 com com NN cord-021413-1ht1xm88 295 28 pared pare VBD cord-021413-1ht1xm88 295 29 with with IN cord-021413-1ht1xm88 295 30 4.6 4.6 CD cord-021413-1ht1xm88 295 31 % % NN cord-021413-1ht1xm88 295 32 in in IN cord-021413-1ht1xm88 295 33 normal normal JJ cord-021413-1ht1xm88 295 34 mice mouse NNS cord-021413-1ht1xm88 295 35 . . . cord-021413-1ht1xm88 296 1 Feces fece NNS cord-021413-1ht1xm88 296 2 may may MD cord-021413-1ht1xm88 296 3 contain contain VB cord-021413-1ht1xm88 296 4 as as RB cord-021413-1ht1xm88 296 5 much much JJ cord-021413-1ht1xm88 296 6 as as IN cord-021413-1ht1xm88 296 7 29 29 CD cord-021413-1ht1xm88 296 8 % % NN cord-021413-1ht1xm88 296 9 fat fat NN cord-021413-1ht1xm88 296 10 in in IN cord-021413-1ht1xm88 296 11 infected infected JJ cord-021413-1ht1xm88 296 12 mice mouse NNS cord-021413-1ht1xm88 297 1 ( ( -LRB- cord-021413-1ht1xm88 297 2 Stanley Stanley NNP cord-021413-1ht1xm88 297 3 et et NNP cord-021413-1ht1xm88 297 4 al al NNP cord-021413-1ht1xm88 297 5 . . NNP cord-021413-1ht1xm88 297 6 , , , cord-021413-1ht1xm88 297 7 1953 1953 CD cord-021413-1ht1xm88 298 1 ( ( -LRB- cord-021413-1ht1xm88 298 2 Stanley Stanley NNP cord-021413-1ht1xm88 298 3 et et NNP cord-021413-1ht1xm88 298 4 al al NNP cord-021413-1ht1xm88 298 5 . . NNP cord-021413-1ht1xm88 298 6 , , , cord-021413-1ht1xm88 298 7 , , , cord-021413-1ht1xm88 298 8 1954 1954 CD cord-021413-1ht1xm88 298 9 . . . cord-021413-1ht1xm88 299 1 The the DT cord-021413-1ht1xm88 299 2 thymus thymus NN cord-021413-1ht1xm88 299 3 and and CC cord-021413-1ht1xm88 299 4 other other JJ cord-021413-1ht1xm88 299 5 organs organ NNS cord-021413-1ht1xm88 299 6 appeared appear VBD cord-021413-1ht1xm88 299 7 normal normal JJ cord-021413-1ht1xm88 299 8 . . . cord-021413-1ht1xm88 300 1 In in IN cord-021413-1ht1xm88 300 2 the the DT cord-021413-1ht1xm88 300 3 central central JJ cord-021413-1ht1xm88 300 4 nervous nervous JJ cord-021413-1ht1xm88 300 5 system system NN cord-021413-1ht1xm88 300 6 , , , cord-021413-1ht1xm88 300 7 neuronal neuronal JJ cord-021413-1ht1xm88 300 8 degeneration degeneration NN cord-021413-1ht1xm88 300 9 began begin VBD cord-021413-1ht1xm88 300 10 about about IN cord-021413-1ht1xm88 300 11 the the DT cord-021413-1ht1xm88 300 12 ninth ninth JJ cord-021413-1ht1xm88 300 13 day day NN cord-021413-1ht1xm88 300 14 and and CC cord-021413-1ht1xm88 300 15 was be VBD cord-021413-1ht1xm88 300 16 most most RBS cord-021413-1ht1xm88 300 17 prominent prominent JJ cord-021413-1ht1xm88 300 18 in in IN cord-021413-1ht1xm88 300 19 the the DT cord-021413-1ht1xm88 300 20 brain brain NN cord-021413-1ht1xm88 300 21 stem stem NN cord-021413-1ht1xm88 300 22 and and CC cord-021413-1ht1xm88 300 23 cerebral cerebral JJ cord-021413-1ht1xm88 300 24 hemispheres hemisphere NNS cord-021413-1ht1xm88 300 25 . . . cord-021413-1ht1xm88 301 1 By by IN cord-021413-1ht1xm88 301 2 the the DT cord-021413-1ht1xm88 301 3 tenth tenth JJ cord-021413-1ht1xm88 301 4 day day NN cord-021413-1ht1xm88 301 5 , , , cord-021413-1ht1xm88 301 6 perivascular perivascular NNP cord-021413-1ht1xm88 301 7 cuf cuf NNP cord-021413-1ht1xm88 301 8 fing fing NNP cord-021413-1ht1xm88 301 9 as as RB cord-021413-1ht1xm88 301 10 well well RB cord-021413-1ht1xm88 301 11 as as IN cord-021413-1ht1xm88 301 12 neuronal neuronal JJ cord-021413-1ht1xm88 301 13 satellitosis satellitosis NN cord-021413-1ht1xm88 301 14 was be VBD cord-021413-1ht1xm88 301 15 evident evident JJ cord-021413-1ht1xm88 301 16 . . . cord-021413-1ht1xm88 302 1 The the DT cord-021413-1ht1xm88 302 2 meninges meninge NNS cord-021413-1ht1xm88 302 3 were be VBD cord-021413-1ht1xm88 302 4 infiltrated infiltrate VBN cord-021413-1ht1xm88 302 5 with with IN cord-021413-1ht1xm88 302 6 round round JJ cord-021413-1ht1xm88 302 7 cells cell NNS cord-021413-1ht1xm88 302 8 and and CC cord-021413-1ht1xm88 302 9 netrophilic netrophilic JJ cord-021413-1ht1xm88 302 10 leukocytes leukocyte NNS cord-021413-1ht1xm88 302 11 . . . cord-021413-1ht1xm88 303 1 By by IN cord-021413-1ht1xm88 303 2 the the DT cord-021413-1ht1xm88 303 3 fourteenth fourteenth JJ cord-021413-1ht1xm88 303 4 day day NN cord-021413-1ht1xm88 303 5 encephalitis encephalitis RB cord-021413-1ht1xm88 303 6 was be VBD cord-021413-1ht1xm88 303 7 severe severe JJ cord-021413-1ht1xm88 303 8 and and CC cord-021413-1ht1xm88 303 9 widespread widespread JJ cord-021413-1ht1xm88 303 10 , , , cord-021413-1ht1xm88 303 11 with with IN cord-021413-1ht1xm88 303 12 small small JJ cord-021413-1ht1xm88 303 13 hemorrhages hemorrhage NNS cord-021413-1ht1xm88 303 14 occurring occur VBG cord-021413-1ht1xm88 303 15 in in IN cord-021413-1ht1xm88 303 16 necrotic necrotic JJ cord-021413-1ht1xm88 303 17 regions region NNS cord-021413-1ht1xm88 303 18 . . . cord-021413-1ht1xm88 304 1 In in IN cord-021413-1ht1xm88 304 2 suckling suckle VBG cord-021413-1ht1xm88 304 3 rats rat NNS cord-021413-1ht1xm88 304 4 inoculated inoculate VBD cord-021413-1ht1xm88 304 5 intracerebrally intracerebrally RB cord-021413-1ht1xm88 304 6 with with IN cord-021413-1ht1xm88 304 7 reovirus reovirus NNP cord-021413-1ht1xm88 304 8 types type NNS cord-021413-1ht1xm88 304 9 1 1 CD cord-021413-1ht1xm88 304 10 , , , cord-021413-1ht1xm88 304 11 2 2 CD cord-021413-1ht1xm88 304 12 , , , cord-021413-1ht1xm88 304 13 or or CC cord-021413-1ht1xm88 304 14 3 3 CD cord-021413-1ht1xm88 304 15 , , , cord-021413-1ht1xm88 304 16 viral viral JJ cord-021413-1ht1xm88 304 17 cytoplasmic cytoplasmic JJ cord-021413-1ht1xm88 304 18 inclusions inclusion NNS cord-021413-1ht1xm88 304 19 and and CC cord-021413-1ht1xm88 304 20 intranuclear intranuclear NN cord-021413-1ht1xm88 304 21 bodies body NNS cord-021413-1ht1xm88 304 22 corresponding correspond VBG cord-021413-1ht1xm88 304 23 to to IN cord-021413-1ht1xm88 304 24 Cowdry Cowdry NNP cord-021413-1ht1xm88 304 25 type type NN cord-021413-1ht1xm88 304 26 Β β NN cord-021413-1ht1xm88 304 27 inclusions inclusion NNS cord-021413-1ht1xm88 304 28 have have VBP cord-021413-1ht1xm88 304 29 been be VBN cord-021413-1ht1xm88 304 30 ob ob NNP cord-021413-1ht1xm88 304 31 served serve VBN cord-021413-1ht1xm88 304 32 ( ( -LRB- cord-021413-1ht1xm88 304 33 Margolis Margolis NNP cord-021413-1ht1xm88 304 34 et et NNP cord-021413-1ht1xm88 304 35 al al NNP cord-021413-1ht1xm88 304 36 . . NNP cord-021413-1ht1xm88 304 37 , , , cord-021413-1ht1xm88 304 38 1975 1975 CD cord-021413-1ht1xm88 304 39 ) ) -RRB- cord-021413-1ht1xm88 304 40 . . . cord-021413-1ht1xm88 305 1 The the DT cord-021413-1ht1xm88 305 2 latter latter JJ cord-021413-1ht1xm88 305 3 were be VBD cord-021413-1ht1xm88 305 4 seen see VBN cord-021413-1ht1xm88 305 5 in in IN cord-021413-1ht1xm88 305 6 cells cell NNS cord-021413-1ht1xm88 305 7 that that WDT cord-021413-1ht1xm88 305 8 were be VBD cord-021413-1ht1xm88 305 9 free free JJ cord-021413-1ht1xm88 305 10 from from IN cord-021413-1ht1xm88 305 11 intracytoplasmic intracytoplasmic JJ cord-021413-1ht1xm88 305 12 inclusions inclusion NNS cord-021413-1ht1xm88 305 13 ; ; : cord-021413-1ht1xm88 305 14 they -PRON- PRP cord-021413-1ht1xm88 305 15 were be VBD cord-021413-1ht1xm88 305 16 readily readily RB cord-021413-1ht1xm88 305 17 found find VBN cord-021413-1ht1xm88 305 18 in in IN cord-021413-1ht1xm88 305 19 weanlings weanling NNS cord-021413-1ht1xm88 305 20 , , , cord-021413-1ht1xm88 305 21 were be VBD cord-021413-1ht1xm88 305 22 unassociated unassociated JJ cord-021413-1ht1xm88 305 23 with with IN cord-021413-1ht1xm88 305 24 inflam inflam NNP cord-021413-1ht1xm88 305 25 and and CC cord-021413-1ht1xm88 305 26 their -PRON- PRP$ cord-021413-1ht1xm88 305 27 microvilli microvilli NN cord-021413-1ht1xm88 305 28 swollen swollen JJ cord-021413-1ht1xm88 305 29 . . . cord-021413-1ht1xm88 306 1 The the DT cord-021413-1ht1xm88 306 2 common common JJ cord-021413-1ht1xm88 306 3 bile bile NN cord-021413-1ht1xm88 306 4 duct duct NN cord-021413-1ht1xm88 306 5 is be VBZ cord-021413-1ht1xm88 306 6 dilated dilate VBN cord-021413-1ht1xm88 306 7 , , , cord-021413-1ht1xm88 306 8 and and CC cord-021413-1ht1xm88 306 9 the the DT cord-021413-1ht1xm88 306 10 ampullary ampullary JJ cord-021413-1ht1xm88 306 11 region region NN cord-021413-1ht1xm88 306 12 becomes become VBZ cord-021413-1ht1xm88 306 13 obstructed obstruct VBN cord-021413-1ht1xm88 306 14 with with IN cord-021413-1ht1xm88 306 15 debris debris NN cord-021413-1ht1xm88 306 16 . . . cord-021413-1ht1xm88 307 1 It -PRON- PRP cord-021413-1ht1xm88 307 2 is be VBZ cord-021413-1ht1xm88 307 3 this this DT cord-021413-1ht1xm88 307 4 obstruction obstruction NN cord-021413-1ht1xm88 307 5 that that WDT cord-021413-1ht1xm88 307 6 leads lead VBZ cord-021413-1ht1xm88 307 7 to to IN cord-021413-1ht1xm88 307 8 both both CC cord-021413-1ht1xm88 307 9 hepatic hepatic JJ cord-021413-1ht1xm88 307 10 and and CC cord-021413-1ht1xm88 307 11 pancreatic pancreatic JJ cord-021413-1ht1xm88 307 12 dys dys NN cord-021413-1ht1xm88 307 13 function function NN cord-021413-1ht1xm88 307 14 , , , cord-021413-1ht1xm88 307 15 for for IN cord-021413-1ht1xm88 307 16 after after IN cord-021413-1ht1xm88 307 17 studying study VBG cord-021413-1ht1xm88 307 18 the the DT cord-021413-1ht1xm88 307 19 pancreatic pancreatic JJ cord-021413-1ht1xm88 307 20 lesions lesion NNS cord-021413-1ht1xm88 307 21 further further RB cord-021413-1ht1xm88 307 22 , , , cord-021413-1ht1xm88 307 23 Papadimitriou Papadimitriou NNP cord-021413-1ht1xm88 307 24 and and CC cord-021413-1ht1xm88 307 25 Walters Walters NNP cord-021413-1ht1xm88 307 26 ( ( -LRB- cord-021413-1ht1xm88 307 27 1967 1967 CD cord-021413-1ht1xm88 307 28 ) ) -RRB- cord-021413-1ht1xm88 307 29 concluded conclude VBD cord-021413-1ht1xm88 307 30 that that IN cord-021413-1ht1xm88 307 31 , , , cord-021413-1ht1xm88 307 32 even even RB cord-021413-1ht1xm88 307 33 though though IN cord-021413-1ht1xm88 307 34 virions virion NNS cord-021413-1ht1xm88 307 35 were be VBD cord-021413-1ht1xm88 307 36 seen see VBN cord-021413-1ht1xm88 307 37 in in IN cord-021413-1ht1xm88 307 38 pancreatic pancreatic JJ cord-021413-1ht1xm88 307 39 acinar acinar NN cord-021413-1ht1xm88 307 40 cells cell NNS cord-021413-1ht1xm88 307 41 , , , cord-021413-1ht1xm88 307 42 the the DT cord-021413-1ht1xm88 307 43 principal principal JJ cord-021413-1ht1xm88 307 44 cause cause NN cord-021413-1ht1xm88 307 45 of of IN cord-021413-1ht1xm88 307 46 acinar acinar JJ cord-021413-1ht1xm88 307 47 degeneration degeneration NN cord-021413-1ht1xm88 307 48 is be VBZ cord-021413-1ht1xm88 307 49 ductal ductal JJ cord-021413-1ht1xm88 307 50 obstruction obstruction NN cord-021413-1ht1xm88 307 51 . . . cord-021413-1ht1xm88 308 1 Based base VBN cord-021413-1ht1xm88 308 2 on on IN cord-021413-1ht1xm88 308 3 the the DT cord-021413-1ht1xm88 308 4 neutralization neutralization NN cord-021413-1ht1xm88 308 5 test test NN cord-021413-1ht1xm88 308 6 , , , cord-021413-1ht1xm88 308 7 determined determine VBD cord-021413-1ht1xm88 308 8 that that IN cord-021413-1ht1xm88 308 9 the the DT cord-021413-1ht1xm88 308 10 SI SI NNP cord-021413-1ht1xm88 308 11 genome genome NN cord-021413-1ht1xm88 308 12 segment segment NN cord-021413-1ht1xm88 308 13 is be VBZ cord-021413-1ht1xm88 308 14 linked link VBN cord-021413-1ht1xm88 308 15 to to IN cord-021413-1ht1xm88 308 16 type type NN cord-021413-1ht1xm88 308 17 speci speci NNP cord-021413-1ht1xm88 308 18 ficity ficity NN cord-021413-1ht1xm88 308 19 , , , cord-021413-1ht1xm88 308 20 and and CC cord-021413-1ht1xm88 308 21 Finberg Finberg NNP cord-021413-1ht1xm88 308 22 et et NNP cord-021413-1ht1xm88 308 23 aL aL NNP cord-021413-1ht1xm88 308 24 ( ( -LRB- cord-021413-1ht1xm88 308 25 1979 1979 CD cord-021413-1ht1xm88 308 26 ) ) -RRB- cord-021413-1ht1xm88 308 27 found find VBD cord-021413-1ht1xm88 308 28 that that IN cord-021413-1ht1xm88 308 29 the the DT cord-021413-1ht1xm88 308 30 same same JJ cord-021413-1ht1xm88 308 31 genome genome NN cord-021413-1ht1xm88 308 32 segment segment NN cord-021413-1ht1xm88 308 33 is be VBZ cord-021413-1ht1xm88 308 34 also also RB cord-021413-1ht1xm88 308 35 responsible responsible JJ cord-021413-1ht1xm88 308 36 for for IN cord-021413-1ht1xm88 308 37 the the DT cord-021413-1ht1xm88 308 38 production production NN cord-021413-1ht1xm88 308 39 of of IN cord-021413-1ht1xm88 308 40 cytolytic cytolytic JJ cord-021413-1ht1xm88 308 41 Τ τ NN cord-021413-1ht1xm88 308 42 lymphocytes lymphocyte NNS cord-021413-1ht1xm88 308 43 after after IN cord-021413-1ht1xm88 308 44 reovirus reovirus NNP cord-021413-1ht1xm88 308 45 infection infection NN cord-021413-1ht1xm88 308 46 . . . cord-021413-1ht1xm88 309 1 Tytell Tytell NNP cord-021413-1ht1xm88 309 2 et et NNP cord-021413-1ht1xm88 309 3 aL aL NNP cord-021413-1ht1xm88 309 4 ( ( -LRB- cord-021413-1ht1xm88 309 5 1967 1967 CD cord-021413-1ht1xm88 309 6 ) ) -RRB- cord-021413-1ht1xm88 309 7 , , , cord-021413-1ht1xm88 309 8 working work VBG cord-021413-1ht1xm88 309 9 with with IN cord-021413-1ht1xm88 309 10 reovirus reovirus NNP cord-021413-1ht1xm88 309 11 3 3 CD cord-021413-1ht1xm88 309 12 RNA RNA NNP cord-021413-1ht1xm88 309 13 , , , cord-021413-1ht1xm88 309 14 found find VBD cord-021413-1ht1xm88 309 15 that that IN cord-021413-1ht1xm88 309 16 it -PRON- PRP cord-021413-1ht1xm88 309 17 was be VBD cord-021413-1ht1xm88 309 18 highly highly RB cord-021413-1ht1xm88 309 19 active active JJ cord-021413-1ht1xm88 309 20 in in IN cord-021413-1ht1xm88 309 21 inducing induce VBG cord-021413-1ht1xm88 309 22 interferon interferon NN cord-021413-1ht1xm88 309 23 in in IN cord-021413-1ht1xm88 309 24 rabbits rabbit NNS cord-021413-1ht1xm88 309 25 and and CC cord-021413-1ht1xm88 309 26 tissue tissue NN cord-021413-1ht1xm88 309 27 culture culture NN cord-021413-1ht1xm88 309 28 , , , cord-021413-1ht1xm88 309 29 and and CC cord-021413-1ht1xm88 309 30 Lai Lai NNP cord-021413-1ht1xm88 309 31 and and CC cord-021413-1ht1xm88 309 32 Joklik Joklik NNP cord-021413-1ht1xm88 309 33 ( ( -LRB- cord-021413-1ht1xm88 309 34 1973 1973 CD cord-021413-1ht1xm88 309 35 ) ) -RRB- cord-021413-1ht1xm88 309 36 showed show VBD cord-021413-1ht1xm88 309 37 that that IN cord-021413-1ht1xm88 309 38 coreless coreless JJ cord-021413-1ht1xm88 309 39 virions virion NNS cord-021413-1ht1xm88 309 40 as as RB cord-021413-1ht1xm88 309 41 well well RB cord-021413-1ht1xm88 309 42 as as IN cord-021413-1ht1xm88 309 43 those those DT cord-021413-1ht1xm88 309 44 lacking lack VBG cord-021413-1ht1xm88 309 45 the the DT cord-021413-1ht1xm88 309 46 outer outer JJ cord-021413-1ht1xm88 309 47 capsid capsid NN cord-021413-1ht1xm88 309 48 shell shell NN cord-021413-1ht1xm88 309 49 induce induce VB cord-021413-1ht1xm88 309 50 no no DT cord-021413-1ht1xm88 309 51 interferon interferon NN cord-021413-1ht1xm88 309 52 . . . cord-021413-1ht1xm88 310 1 The the DT cord-021413-1ht1xm88 310 2 question question NN cord-021413-1ht1xm88 310 3 of of IN cord-021413-1ht1xm88 310 4 the the DT cord-021413-1ht1xm88 310 5 role role NN cord-021413-1ht1xm88 310 6 of of IN cord-021413-1ht1xm88 310 7 interferon interferon NN cord-021413-1ht1xm88 310 8 in in IN cord-021413-1ht1xm88 310 9 protection protection NN cord-021413-1ht1xm88 310 10 of of IN cord-021413-1ht1xm88 310 11 mice mouse NNS cord-021413-1ht1xm88 310 12 from from IN cord-021413-1ht1xm88 310 13 either either CC cord-021413-1ht1xm88 310 14 the the DT cord-021413-1ht1xm88 310 15 acute acute JJ cord-021413-1ht1xm88 310 16 or or CC cord-021413-1ht1xm88 310 17 chronic chronic JJ cord-021413-1ht1xm88 310 18 infection infection NN cord-021413-1ht1xm88 310 19 remains remain VBZ cord-021413-1ht1xm88 310 20 an an DT cord-021413-1ht1xm88 310 21 intriguing intriguing JJ cord-021413-1ht1xm88 310 22 problem problem NN cord-021413-1ht1xm88 310 23 . . . cord-021413-1ht1xm88 311 1 In in IN cord-021413-1ht1xm88 311 2 an an DT cord-021413-1ht1xm88 311 3 effort effort NN cord-021413-1ht1xm88 311 4 to to TO cord-021413-1ht1xm88 311 5 permit permit VB cord-021413-1ht1xm88 311 6 a a DT cord-021413-1ht1xm88 311 7 precise precise JJ cord-021413-1ht1xm88 311 8 definition definition NN cord-021413-1ht1xm88 311 9 of of IN cord-021413-1ht1xm88 311 10 the the DT cord-021413-1ht1xm88 311 11 host host NN cord-021413-1ht1xm88 311 12 cellular cellular JJ cord-021413-1ht1xm88 311 13 immune immune JJ cord-021413-1ht1xm88 311 14 response response NN cord-021413-1ht1xm88 311 15 to to IN cord-021413-1ht1xm88 311 16 viral viral JJ cord-021413-1ht1xm88 311 17 antigens antigen NNS cord-021413-1ht1xm88 311 18 , , , cord-021413-1ht1xm88 311 19 Weiner Weiner NNP cord-021413-1ht1xm88 311 20 et et NNP cord-021413-1ht1xm88 311 21 aL aL NNP cord-021413-1ht1xm88 311 22 ( ( -LRB- cord-021413-1ht1xm88 311 23 1980b 1980b CD cord-021413-1ht1xm88 311 24 ) ) -RRB- cord-021413-1ht1xm88 311 25 and and CC cord-021413-1ht1xm88 311 26 Greene Greene NNP cord-021413-1ht1xm88 311 27 and and CC cord-021413-1ht1xm88 311 28 Weiner Weiner NNP cord-021413-1ht1xm88 311 29 ( ( -LRB- cord-021413-1ht1xm88 311 30 1980 1980 CD cord-021413-1ht1xm88 311 31 ) ) -RRB- cord-021413-1ht1xm88 311 32 which which WDT cord-021413-1ht1xm88 311 33 also also RB cord-021413-1ht1xm88 311 34 determined determine VBD cord-021413-1ht1xm88 311 35 serotype serotype NN cord-021413-1ht1xm88 311 36 - - HYPH cord-021413-1ht1xm88 311 37 specific specific JJ cord-021413-1ht1xm88 311 38 humoral humoral JJ cord-021413-1ht1xm88 311 39 ( ( -LRB- cord-021413-1ht1xm88 311 40 neutraliz neutraliz JJ cord-021413-1ht1xm88 311 41 ing ing NNP cord-021413-1ht1xm88 311 42 ) ) -RRB- cord-021413-1ht1xm88 311 43 and and CC cord-021413-1ht1xm88 311 44 cytolytic cytolytic NNP cord-021413-1ht1xm88 311 45 T t NN cord-021413-1ht1xm88 311 46 - - HYPH cord-021413-1ht1xm88 311 47 cell cell NN cord-021413-1ht1xm88 311 48 responses response NNS cord-021413-1ht1xm88 311 49 . . . cord-021413-1ht1xm88 312 1 It -PRON- PRP cord-021413-1ht1xm88 312 2 is be VBZ cord-021413-1ht1xm88 312 3 clear clear JJ cord-021413-1ht1xm88 312 4 that that IN cord-021413-1ht1xm88 312 5 the the DT cord-021413-1ht1xm88 312 6 agent agent NN cord-021413-1ht1xm88 312 7 can can MD cord-021413-1ht1xm88 312 8 be be VB cord-021413-1ht1xm88 312 9 transmitted transmit VBN cord-021413-1ht1xm88 312 10 by by IN cord-021413-1ht1xm88 312 11 the the DT cord-021413-1ht1xm88 312 12 oral oral JJ cord-021413-1ht1xm88 312 13 route route NN cord-021413-1ht1xm88 312 14 as as RB cord-021413-1ht1xm88 312 15 well well RB cord-021413-1ht1xm88 312 16 as as IN cord-021413-1ht1xm88 312 17 by by IN cord-021413-1ht1xm88 312 18 parenteral parenteral JJ cord-021413-1ht1xm88 312 19 inoculation inoculation NN cord-021413-1ht1xm88 312 20 . . . cord-021413-1ht1xm88 312 21 _SP cord-021413-1ht1xm88 313 1 Mice mouse NNS cord-021413-1ht1xm88 313 2 respond respond VBP cord-021413-1ht1xm88 313 3 to to IN cord-021413-1ht1xm88 313 4 the the DT cord-021413-1ht1xm88 313 5 natural natural JJ cord-021413-1ht1xm88 313 6 infection infection NN cord-021413-1ht1xm88 313 7 with with IN cord-021413-1ht1xm88 313 8 neutralizing neutralize VBG cord-021413-1ht1xm88 313 9 , , , cord-021413-1ht1xm88 313 10 hemagglutination hemagglutination NN cord-021413-1ht1xm88 313 11 - - HYPH cord-021413-1ht1xm88 313 12 inhibiting inhibit VBG cord-021413-1ht1xm88 313 13 , , , cord-021413-1ht1xm88 313 14 and and CC cord-021413-1ht1xm88 313 15 complement complement NN cord-021413-1ht1xm88 313 16 - - HYPH cord-021413-1ht1xm88 313 17 fixing fix VBG cord-021413-1ht1xm88 313 18 an an DT cord-021413-1ht1xm88 313 19 tibodies tibodie NNS cord-021413-1ht1xm88 313 20 . . . cord-021413-1ht1xm88 314 1 As as IN cord-021413-1ht1xm88 314 2 indicated indicate VBN cord-021413-1ht1xm88 314 3 earlier early RBR cord-021413-1ht1xm88 314 4 ( ( -LRB- cord-021413-1ht1xm88 314 5 Section section NN cord-021413-1ht1xm88 314 6 III III NNP cord-021413-1ht1xm88 314 7 , , , cord-021413-1ht1xm88 314 8 B,3,^ B,3,^ NNP cord-021413-1ht1xm88 314 9 ) ) -RRB- cord-021413-1ht1xm88 314 10 , , , cord-021413-1ht1xm88 314 11 precipitating precipitate VBG cord-021413-1ht1xm88 314 12 antibodies antibody NNS cord-021413-1ht1xm88 314 13 can can MD cord-021413-1ht1xm88 314 14 also also RB cord-021413-1ht1xm88 314 15 be be VB cord-021413-1ht1xm88 314 16 demonstrated demonstrate VBN cord-021413-1ht1xm88 314 17 . . . cord-021413-1ht1xm88 315 1 There there EX cord-021413-1ht1xm88 315 2 is be VBZ cord-021413-1ht1xm88 315 3 no no DT cord-021413-1ht1xm88 315 4 evi evi FW cord-021413-1ht1xm88 315 5 dence dence NN cord-021413-1ht1xm88 315 6 that that IN cord-021413-1ht1xm88 315 7 any any DT cord-021413-1ht1xm88 315 8 mouse mouse NN cord-021413-1ht1xm88 315 9 strain strain NN cord-021413-1ht1xm88 315 10 is be VBZ cord-021413-1ht1xm88 315 11 more more RBR cord-021413-1ht1xm88 315 12 or or CC cord-021413-1ht1xm88 315 13 less less RBR cord-021413-1ht1xm88 315 14 susceptible susceptible JJ cord-021413-1ht1xm88 315 15 to to IN cord-021413-1ht1xm88 315 16 reovirus reovirus NN cord-021413-1ht1xm88 315 17 3 3 CD cord-021413-1ht1xm88 315 18 infection infection NN cord-021413-1ht1xm88 315 19 than than IN cord-021413-1ht1xm88 315 20 any any DT cord-021413-1ht1xm88 315 21 other other JJ cord-021413-1ht1xm88 315 22 , , , cord-021413-1ht1xm88 315 23 provided provide VBD cord-021413-1ht1xm88 315 24 the the DT cord-021413-1ht1xm88 315 25 animals animal NNS cord-021413-1ht1xm88 315 26 come come VBP cord-021413-1ht1xm88 315 27 from from IN cord-021413-1ht1xm88 315 28 a a DT cord-021413-1ht1xm88 315 29 colony colony NN cord-021413-1ht1xm88 315 30 that that WDT cord-021413-1ht1xm88 315 31 is be VBZ cord-021413-1ht1xm88 315 32 free free JJ cord-021413-1ht1xm88 315 33 of of IN cord-021413-1ht1xm88 315 34 the the DT cord-021413-1ht1xm88 315 35 infection infection NN cord-021413-1ht1xm88 315 36 . . . cord-021413-1ht1xm88 316 1 The the DT cord-021413-1ht1xm88 316 2 host host NN cord-021413-1ht1xm88 316 3 range range NN cord-021413-1ht1xm88 316 4 is be VBZ cord-021413-1ht1xm88 316 5 broad broad JJ cord-021413-1ht1xm88 316 6 . . . cord-021413-1ht1xm88 317 1 Stanley Stanley NNP cord-021413-1ht1xm88 317 2 ( ( -LRB- cord-021413-1ht1xm88 317 3 1974 1974 CD cord-021413-1ht1xm88 317 4 ) ) -RRB- cord-021413-1ht1xm88 317 5 cited cite VBD cord-021413-1ht1xm88 317 6 at at IN cord-021413-1ht1xm88 317 7 least least RBS cord-021413-1ht1xm88 317 8 60 60 CD cord-021413-1ht1xm88 317 9 species specie NNS cord-021413-1ht1xm88 317 10 that that WDT cord-021413-1ht1xm88 317 11 may may MD cord-021413-1ht1xm88 317 12 be be VB cord-021413-1ht1xm88 317 13 infected infect VBN cord-021413-1ht1xm88 317 14 with with IN cord-021413-1ht1xm88 317 15 reoviruses reovirus NNS cord-021413-1ht1xm88 317 16 , , , cord-021413-1ht1xm88 317 17 and and CC cord-021413-1ht1xm88 317 18 , , , cord-021413-1ht1xm88 317 19 as as IN cord-021413-1ht1xm88 317 20 men man NNS cord-021413-1ht1xm88 317 21 tioned tione VBN cord-021413-1ht1xm88 317 22 above above RB cord-021413-1ht1xm88 317 23 , , , cord-021413-1ht1xm88 317 24 it -PRON- PRP cord-021413-1ht1xm88 317 25 is be VBZ cord-021413-1ht1xm88 317 26 thought think VBN cord-021413-1ht1xm88 317 27 that that IN cord-021413-1ht1xm88 317 28 the the DT cord-021413-1ht1xm88 317 29 prevalence prevalence NN cord-021413-1ht1xm88 317 30 of of IN cord-021413-1ht1xm88 317 31 antibodies antibody NNS cord-021413-1ht1xm88 317 32 in in IN cord-021413-1ht1xm88 317 33 otherwise otherwise RB cord-021413-1ht1xm88 317 34 normal normal JJ cord-021413-1ht1xm88 317 35 mammals mammal NNS cord-021413-1ht1xm88 317 36 is be VBZ cord-021413-1ht1xm88 317 37 related relate VBN cord-021413-1ht1xm88 317 38 to to IN cord-021413-1ht1xm88 317 39 this this DT cord-021413-1ht1xm88 317 40 fact fact NN cord-021413-1ht1xm88 317 41 and and CC cord-021413-1ht1xm88 317 42 that that IN cord-021413-1ht1xm88 317 43 mosquitoes mosquito NNS cord-021413-1ht1xm88 317 44 or or CC cord-021413-1ht1xm88 317 45 other other JJ cord-021413-1ht1xm88 317 46 insects insect NNS cord-021413-1ht1xm88 317 47 may may MD cord-021413-1ht1xm88 317 48 be be VB cord-021413-1ht1xm88 317 49 operational operational JJ cord-021413-1ht1xm88 317 50 in in IN cord-021413-1ht1xm88 317 51 the the DT cord-021413-1ht1xm88 317 52 spread spread NN cord-021413-1ht1xm88 317 53 of of IN cord-021413-1ht1xm88 317 54 the the DT cord-021413-1ht1xm88 317 55 infection infection NN cord-021413-1ht1xm88 317 56 . . . cord-021413-1ht1xm88 318 1 The the DT cord-021413-1ht1xm88 318 2 acute acute JJ cord-021413-1ht1xm88 318 3 disease disease NN cord-021413-1ht1xm88 318 4 affects affect VBZ cord-021413-1ht1xm88 318 5 mainly mainly RB cord-021413-1ht1xm88 318 6 sucklings suckling NNS cord-021413-1ht1xm88 318 7 and and CC cord-021413-1ht1xm88 318 8 weanlings weanling NNS cord-021413-1ht1xm88 318 9 , , , cord-021413-1ht1xm88 318 10 whereas whereas IN cord-021413-1ht1xm88 318 11 the the DT cord-021413-1ht1xm88 318 12 chronic chronic JJ cord-021413-1ht1xm88 318 13 disease disease NN cord-021413-1ht1xm88 318 14 is be VBZ cord-021413-1ht1xm88 318 15 encountered encounter VBN cord-021413-1ht1xm88 318 16 in in IN cord-021413-1ht1xm88 318 17 animals animal NNS cord-021413-1ht1xm88 318 18 over over IN cord-021413-1ht1xm88 318 19 28 28 CD cord-021413-1ht1xm88 318 20 days day NNS cord-021413-1ht1xm88 318 21 of of IN cord-021413-1ht1xm88 318 22 age age NN cord-021413-1ht1xm88 318 23 . . . cord-021413-1ht1xm88 319 1 There there EX cord-021413-1ht1xm88 319 2 is be VBZ cord-021413-1ht1xm88 319 3 no no DT cord-021413-1ht1xm88 319 4 indica indica JJ cord-021413-1ht1xm88 319 5 tion tion NN cord-021413-1ht1xm88 319 6 that that WDT cord-021413-1ht1xm88 319 7 either either CC cord-021413-1ht1xm88 319 8 sex sex NN cord-021413-1ht1xm88 319 9 is be VBZ cord-021413-1ht1xm88 319 10 more more RBR cord-021413-1ht1xm88 319 11 or or CC cord-021413-1ht1xm88 319 12 less less RBR cord-021413-1ht1xm88 319 13 susceptible susceptible JJ cord-021413-1ht1xm88 319 14 than than IN cord-021413-1ht1xm88 319 15 the the DT cord-021413-1ht1xm88 319 16 other other JJ cord-021413-1ht1xm88 319 17 . . . cord-021413-1ht1xm88 320 1 In in IN cord-021413-1ht1xm88 320 2 an an DT cord-021413-1ht1xm88 320 3 epizootic epizootic NN cord-021413-1ht1xm88 320 4 described describe VBN cord-021413-1ht1xm88 320 5 by by IN cord-021413-1ht1xm88 320 6 Cook Cook NNP cord-021413-1ht1xm88 320 7 ( ( -LRB- cord-021413-1ht1xm88 320 8 1963 1963 CD cord-021413-1ht1xm88 320 9 ) ) -RRB- cord-021413-1ht1xm88 320 10 , , , cord-021413-1ht1xm88 320 11 130 130 CD cord-021413-1ht1xm88 320 12 of of IN cord-021413-1ht1xm88 320 13 800 800 CD cord-021413-1ht1xm88 320 14 first first JJ cord-021413-1ht1xm88 320 15 litters litter NNS cord-021413-1ht1xm88 320 16 were be VBD cord-021413-1ht1xm88 320 17 affected affect VBN cord-021413-1ht1xm88 320 18 . . . cord-021413-1ht1xm88 321 1 Later later RBR cord-021413-1ht1xm88 321 2 - - HYPH cord-021413-1ht1xm88 321 3 parity parity NN cord-021413-1ht1xm88 321 4 litters litter NNS cord-021413-1ht1xm88 321 5 were be VBD cord-021413-1ht1xm88 321 6 involved involve VBN cord-021413-1ht1xm88 321 7 hardly hardly RB cord-021413-1ht1xm88 321 8 at at RB cord-021413-1ht1xm88 321 9 all all RB cord-021413-1ht1xm88 321 10 . . . cord-021413-1ht1xm88 322 1 In in IN cord-021413-1ht1xm88 322 2 view view NN cord-021413-1ht1xm88 322 3 of of IN cord-021413-1ht1xm88 322 4 the the DT cord-021413-1ht1xm88 322 5 absent absent JJ cord-021413-1ht1xm88 322 6 or or CC cord-021413-1ht1xm88 322 7 low low JJ cord-021413-1ht1xm88 322 8 complement complement NN cord-021413-1ht1xm88 322 9 - - HYPH cord-021413-1ht1xm88 322 10 fixing fix VBG cord-021413-1ht1xm88 322 11 antibody antibody NN cord-021413-1ht1xm88 322 12 titers titer NNS cord-021413-1ht1xm88 322 13 in in IN cord-021413-1ht1xm88 322 14 the the DT cord-021413-1ht1xm88 322 15 presence presence NN cord-021413-1ht1xm88 322 16 of of IN cord-021413-1ht1xm88 322 17 significant significant JJ cord-021413-1ht1xm88 322 18 hemagglutination hemagglutination NN cord-021413-1ht1xm88 322 19 - - HYPH cord-021413-1ht1xm88 322 20 inhibiting inhibit VBG cord-021413-1ht1xm88 322 21 titers titer NNS cord-021413-1ht1xm88 322 22 that that WDT cord-021413-1ht1xm88 322 23 follow follow VBP cord-021413-1ht1xm88 322 24 natural natural JJ cord-021413-1ht1xm88 322 25 infection infection NN cord-021413-1ht1xm88 322 26 , , , cord-021413-1ht1xm88 322 27 prevalence prevalence NN cord-021413-1ht1xm88 322 28 estimation estimation NN cord-021413-1ht1xm88 322 29 by by IN cord-021413-1ht1xm88 322 30 immunologic immunologic JJ cord-021413-1ht1xm88 322 31 means mean NNS cord-021413-1ht1xm88 322 32 may may MD cord-021413-1ht1xm88 322 33 be be VB cord-021413-1ht1xm88 322 34 difficult difficult JJ cord-021413-1ht1xm88 322 35 to to TO cord-021413-1ht1xm88 322 36 assess assess VB cord-021413-1ht1xm88 322 37 . . . cord-021413-1ht1xm88 323 1 The the DT cord-021413-1ht1xm88 323 2 data datum NNS cord-021413-1ht1xm88 323 3 cited cite VBN cord-021413-1ht1xm88 323 4 by by IN cord-021413-1ht1xm88 323 5 Parker Parker NNP cord-021413-1ht1xm88 323 6 et et NNP cord-021413-1ht1xm88 323 7 al al NNP cord-021413-1ht1xm88 323 8 . . . cord-021413-1ht1xm88 324 1 ( ( -LRB- cord-021413-1ht1xm88 324 2 1966 1966 CD cord-021413-1ht1xm88 324 3 ) ) -RRB- cord-021413-1ht1xm88 324 4 , , , cord-021413-1ht1xm88 324 5 82 82 CD cord-021413-1ht1xm88 324 6 % % NN cord-021413-1ht1xm88 324 7 of of IN cord-021413-1ht1xm88 324 8 34 34 CD cord-021413-1ht1xm88 324 9 colonies colony NNS cord-021413-1ht1xm88 324 10 positive positive JJ cord-021413-1ht1xm88 324 11 , , , cord-021413-1ht1xm88 324 12 and and CC cord-021413-1ht1xm88 324 13 by by IN cord-021413-1ht1xm88 324 14 Descoteaux Descoteaux NNP cord-021413-1ht1xm88 324 15 et et NNP cord-021413-1ht1xm88 324 16 al al NNP cord-021413-1ht1xm88 324 17 . . . cord-021413-1ht1xm88 325 1 ( ( -LRB- cord-021413-1ht1xm88 325 2 1977 1977 CD cord-021413-1ht1xm88 325 3 ) ) -RRB- cord-021413-1ht1xm88 325 4 , , , cord-021413-1ht1xm88 325 5 100 100 CD cord-021413-1ht1xm88 325 6 % % NN cord-021413-1ht1xm88 325 7 of of IN cord-021413-1ht1xm88 325 8 five five CD cord-021413-1ht1xm88 325 9 colonies colony NNS cord-021413-1ht1xm88 325 10 posifive posifive JJ cord-021413-1ht1xm88 325 11 , , , cord-021413-1ht1xm88 325 12 may may MD cord-021413-1ht1xm88 325 13 be be VB cord-021413-1ht1xm88 325 14 typical typical JJ cord-021413-1ht1xm88 325 15 incidences incidence NNS cord-021413-1ht1xm88 325 16 for for IN cord-021413-1ht1xm88 325 17 conventional conventional JJ cord-021413-1ht1xm88 325 18 mouse mouse NN cord-021413-1ht1xm88 325 19 colonies colony NNS cord-021413-1ht1xm88 325 20 . . . cord-021413-1ht1xm88 326 1 As as IN cord-021413-1ht1xm88 326 2 already already RB cord-021413-1ht1xm88 326 3 indicated indicate VBN cord-021413-1ht1xm88 326 4 , , , cord-021413-1ht1xm88 326 5 reovirus reovirus NNP cord-021413-1ht1xm88 326 6 3 3 CD cord-021413-1ht1xm88 326 7 infection infection NN cord-021413-1ht1xm88 326 8 is be VBZ cord-021413-1ht1xm88 326 9 regarded regard VBN cord-021413-1ht1xm88 326 10 as as RB cord-021413-1ht1xm88 326 11 worldwide worldwide RB cord-021413-1ht1xm88 326 12 in in IN cord-021413-1ht1xm88 326 13 distribution distribution NN cord-021413-1ht1xm88 326 14 . . . cord-021413-1ht1xm88 327 1 This this DT cord-021413-1ht1xm88 327 2 aspect aspect NN cord-021413-1ht1xm88 327 3 of of IN cord-021413-1ht1xm88 327 4 reovirus reovirus NNP cord-021413-1ht1xm88 327 5 3 3 CD cord-021413-1ht1xm88 327 6 infection infection NN cord-021413-1ht1xm88 327 7 has have VBZ cord-021413-1ht1xm88 327 8 been be VBN cord-021413-1ht1xm88 327 9 covered cover VBN cord-021413-1ht1xm88 327 10 above above IN cord-021413-1ht1xm88 327 11 ( ( -LRB- cord-021413-1ht1xm88 327 12 Section section NN cord-021413-1ht1xm88 327 13 III III NNP cord-021413-1ht1xm88 327 14 , , , cord-021413-1ht1xm88 327 15 B b NN cord-021413-1ht1xm88 327 16 , , , cord-021413-1ht1xm88 327 17 l,2a l,2a NNS cord-021413-1ht1xm88 327 18 , , , cord-021413-1ht1xm88 327 19 ¿ ¿ FW cord-021413-1ht1xm88 327 20 ? ? . cord-021413-1ht1xm88 327 21 ) ) -RRB- cord-021413-1ht1xm88 327 22 . . . cord-021413-1ht1xm88 328 1 munoperoxidase munoperoxidase NNP cord-021413-1ht1xm88 328 2 method method NNP cord-021413-1ht1xm88 328 3 ( ( -LRB- cord-021413-1ht1xm88 328 4 enzyme enzyme NN cord-021413-1ht1xm88 328 5 - - HYPH cord-021413-1ht1xm88 328 6 labeled label VBN cord-021413-1ht1xm88 328 7 antibody antibody NN cord-021413-1ht1xm88 328 8 ) ) -RRB- cord-021413-1ht1xm88 328 9 has have VBZ cord-021413-1ht1xm88 328 10 been be VBN cord-021413-1ht1xm88 328 11 employed employ VBN cord-021413-1ht1xm88 328 12 for for IN cord-021413-1ht1xm88 328 13 reovirus reovirus NNP cord-021413-1ht1xm88 328 14 1 1 CD cord-021413-1ht1xm88 328 15 ( ( -LRB- cord-021413-1ht1xm88 328 16 Ubertini Ubertini NNP cord-021413-1ht1xm88 328 17 et et NNP cord-021413-1ht1xm88 328 18 al al NNP cord-021413-1ht1xm88 328 19 . . NNP cord-021413-1ht1xm88 328 20 , , , cord-021413-1ht1xm88 328 21 1971 1971 CD cord-021413-1ht1xm88 328 22 ) ) -RRB- cord-021413-1ht1xm88 328 23 and and CC cord-021413-1ht1xm88 328 24 may may MD cord-021413-1ht1xm88 328 25 find find VB cord-021413-1ht1xm88 328 26 application application NN cord-021413-1ht1xm88 328 27 for for IN cord-021413-1ht1xm88 328 28 reovirus reovirus NNP cord-021413-1ht1xm88 328 29 3 3 CD cord-021413-1ht1xm88 328 30 diagnosis diagnosis NN cord-021413-1ht1xm88 328 31 as as RB cord-021413-1ht1xm88 328 32 well well RB cord-021413-1ht1xm88 328 33 . . . cord-021413-1ht1xm88 329 1 Although although IN cord-021413-1ht1xm88 329 2 OHE OHE NNP cord-021413-1ht1xm88 329 3 may may MD cord-021413-1ht1xm88 329 4 not not RB cord-021413-1ht1xm88 329 5 be be VB cord-021413-1ht1xm88 329 6 absolutely absolutely RB cord-021413-1ht1xm88 329 7 pathognomonic pathognomonic JJ cord-021413-1ht1xm88 329 8 for for IN cord-021413-1ht1xm88 329 9 reovirus reovirus NNP cord-021413-1ht1xm88 329 10 3 3 CD cord-021413-1ht1xm88 329 11 infection infection NN cord-021413-1ht1xm88 329 12 , , , cord-021413-1ht1xm88 329 13 it -PRON- PRP cord-021413-1ht1xm88 329 14 seems seem VBZ cord-021413-1ht1xm88 329 15 distinctive distinctive JJ cord-021413-1ht1xm88 329 16 enough enough RB cord-021413-1ht1xm88 329 17 so so IN cord-021413-1ht1xm88 329 18 that that IN cord-021413-1ht1xm88 329 19 a a DT cord-021413-1ht1xm88 329 20 provisional provisional JJ cord-021413-1ht1xm88 329 21 diagnosis diagnosis NN cord-021413-1ht1xm88 329 22 may may MD cord-021413-1ht1xm88 329 23 be be VB cord-021413-1ht1xm88 329 24 made make VBN cord-021413-1ht1xm88 329 25 when when WRB cord-021413-1ht1xm88 329 26 it -PRON- PRP cord-021413-1ht1xm88 329 27 is be VBZ cord-021413-1ht1xm88 329 28 seen see VBN cord-021413-1ht1xm88 329 29 . . . cord-021413-1ht1xm88 330 1 Stronger strong JJR cord-021413-1ht1xm88 330 2 evidence evidence NN cord-021413-1ht1xm88 330 3 is be VBZ cord-021413-1ht1xm88 330 4 afforded afford VBN cord-021413-1ht1xm88 330 5 if if IN cord-021413-1ht1xm88 330 6 the the DT cord-021413-1ht1xm88 330 7 animals animal NNS cord-021413-1ht1xm88 330 8 are be VBP cord-021413-1ht1xm88 330 9 also also RB cord-021413-1ht1xm88 330 10 jaundiced jaundiced JJ cord-021413-1ht1xm88 330 11 and and CC cord-021413-1ht1xm88 330 12 wasted waste VBN cord-021413-1ht1xm88 330 13 . . . cord-021413-1ht1xm88 331 1 Necropsy necropsy NN cord-021413-1ht1xm88 331 2 coupled couple VBN cord-021413-1ht1xm88 331 3 with with IN cord-021413-1ht1xm88 331 4 histopathologic histopathologic JJ cord-021413-1ht1xm88 331 5 examination examination NN cord-021413-1ht1xm88 331 6 is be VBZ cord-021413-1ht1xm88 331 7 never never RB cord-021413-1ht1xm88 331 8 a a DT cord-021413-1ht1xm88 331 9 mistake mistake NN cord-021413-1ht1xm88 331 10 and and CC cord-021413-1ht1xm88 331 11 is be VBZ cord-021413-1ht1xm88 331 12 to to TO cord-021413-1ht1xm88 331 13 be be VB cord-021413-1ht1xm88 331 14 encouraged encourage VBN cord-021413-1ht1xm88 331 15 . . . cord-021413-1ht1xm88 332 1 The the DT cord-021413-1ht1xm88 332 2 placement placement NN cord-021413-1ht1xm88 332 3 of of IN cord-021413-1ht1xm88 332 4 sentinel sentinel JJ cord-021413-1ht1xm88 332 5 animals animal NNS cord-021413-1ht1xm88 332 6 at at IN cord-021413-1ht1xm88 332 7 strategic strategic JJ cord-021413-1ht1xm88 332 8 locations location NNS cord-021413-1ht1xm88 332 9 in in IN cord-021413-1ht1xm88 332 10 an an DT cord-021413-1ht1xm88 332 11 animal animal NN cord-021413-1ht1xm88 332 12 colony colony NN cord-021413-1ht1xm88 332 13 should should MD cord-021413-1ht1xm88 332 14 be be VB cord-021413-1ht1xm88 332 15 considered consider VBN cord-021413-1ht1xm88 332 16 . . . cord-021413-1ht1xm88 333 1 Such such JJ cord-021413-1ht1xm88 333 2 animals animal NNS cord-021413-1ht1xm88 333 3 may may MD cord-021413-1ht1xm88 333 4 be be VB cord-021413-1ht1xm88 333 5 regarded regard VBN cord-021413-1ht1xm88 333 6 as as RB cord-021413-1ht1xm88 333 7 expendable expendable JJ cord-021413-1ht1xm88 333 8 for for IN cord-021413-1ht1xm88 333 9 sacrific sacrific NNP cord-021413-1ht1xm88 333 10 , , , cord-021413-1ht1xm88 333 11 necropsy necropsy JJ cord-021413-1ht1xm88 333 12 , , , cord-021413-1ht1xm88 333 13 and and CC cord-021413-1ht1xm88 333 14 virus virus NN cord-021413-1ht1xm88 333 15 isolation isolation NN cord-021413-1ht1xm88 333 16 as as RB cord-021413-1ht1xm88 333 17 well well RB cord-021413-1ht1xm88 333 18 as as IN cord-021413-1ht1xm88 333 19 for for IN cord-021413-1ht1xm88 333 20 the the DT cord-021413-1ht1xm88 333 21 acquisition acquisition NN cord-021413-1ht1xm88 333 22 of of IN cord-021413-1ht1xm88 333 23 serum serum NN cord-021413-1ht1xm88 333 24 for for IN cord-021413-1ht1xm88 333 25 antibody antibody NN cord-021413-1ht1xm88 333 26 determinations determination NNS cord-021413-1ht1xm88 333 27 . . . cord-021413-1ht1xm88 334 1 There there EX cord-021413-1ht1xm88 334 2 is be VBZ cord-021413-1ht1xm88 334 3 no no DT cord-021413-1ht1xm88 334 4 evidence evidence NN cord-021413-1ht1xm88 334 5 that that IN cord-021413-1ht1xm88 334 6 epizootics epizootic NNS cord-021413-1ht1xm88 334 7 occur occur VBP cord-021413-1ht1xm88 334 8 preferentially preferentially RB cord-021413-1ht1xm88 334 9 at at IN cord-021413-1ht1xm88 334 10 a a DT cord-021413-1ht1xm88 334 11 particular particular JJ cord-021413-1ht1xm88 334 12 time time NN cord-021413-1ht1xm88 334 13 of of IN cord-021413-1ht1xm88 334 14 the the DT cord-021413-1ht1xm88 334 15 year year NN cord-021413-1ht1xm88 334 16 . . . cord-021413-1ht1xm88 335 1 J. J. NNP cord-021413-1ht1xm88 335 2 C. C. NNP cord-021413-1ht1xm88 335 3 Parker Parker NNP cord-021413-1ht1xm88 335 4 et et NNP cord-021413-1ht1xm88 335 5 al al NNP cord-021413-1ht1xm88 335 6 . . . cord-021413-1ht1xm88 336 1 ( ( -LRB- cord-021413-1ht1xm88 336 2 1965 1965 CD cord-021413-1ht1xm88 336 3 , , , cord-021413-1ht1xm88 336 4 1966 1966 CD cord-021413-1ht1xm88 336 5 ) ) -RRB- cord-021413-1ht1xm88 336 6 discussed discuss VBD cord-021413-1ht1xm88 336 7 the the DT cord-021413-1ht1xm88 336 8 serologic serologic NNP cord-021413-1ht1xm88 336 9 diagnosis diagnosis NN cord-021413-1ht1xm88 336 10 of of IN cord-021413-1ht1xm88 336 11 reovirus reovirus NNP cord-021413-1ht1xm88 336 12 3 3 CD cord-021413-1ht1xm88 336 13 infection infection NN cord-021413-1ht1xm88 336 14 , , , cord-021413-1ht1xm88 336 15 concluding conclude VBG cord-021413-1ht1xm88 336 16 that that IN cord-021413-1ht1xm88 336 17 for for IN cord-021413-1ht1xm88 336 18 these these DT cord-021413-1ht1xm88 336 19 puφoses puφose NNS cord-021413-1ht1xm88 336 20 the the DT cord-021413-1ht1xm88 336 21 hemagglutination hemagglutination NN cord-021413-1ht1xm88 336 22 inhibition inhibition NN cord-021413-1ht1xm88 336 23 test test NN cord-021413-1ht1xm88 336 24 was be VBD cord-021413-1ht1xm88 336 25 the the DT cord-021413-1ht1xm88 336 26 most most RBS cord-021413-1ht1xm88 336 27 reliable reliable JJ cord-021413-1ht1xm88 336 28 . . . cord-021413-1ht1xm88 337 1 In in IN cord-021413-1ht1xm88 337 2 preparing prepare VBG cord-021413-1ht1xm88 337 3 type type NN cord-021413-1ht1xm88 337 4 - - HYPH cord-021413-1ht1xm88 337 5 specific specific JJ cord-021413-1ht1xm88 337 6 antisera antisera NN cord-021413-1ht1xm88 337 7 for for IN cord-021413-1ht1xm88 337 8 standardizafion standardizafion NN cord-021413-1ht1xm88 337 9 and and CC cord-021413-1ht1xm88 337 10 controls control NNS cord-021413-1ht1xm88 337 11 , , , cord-021413-1ht1xm88 337 12 Behbehani Behbehani NNP cord-021413-1ht1xm88 337 13 et et NNP cord-021413-1ht1xm88 337 14 al al NNP cord-021413-1ht1xm88 337 15 . . . cord-021413-1ht1xm88 338 1 ( ( -LRB- cord-021413-1ht1xm88 338 2 1966 1966 CD cord-021413-1ht1xm88 338 3 ) ) -RRB- cord-021413-1ht1xm88 338 4 found find VBD cord-021413-1ht1xm88 338 5 that that IN cord-021413-1ht1xm88 338 6 the the DT cord-021413-1ht1xm88 338 7 ubiquity ubiquity NN cord-021413-1ht1xm88 338 8 of of IN cord-021413-1ht1xm88 338 9 inhibitory inhibitory JJ cord-021413-1ht1xm88 338 10 substances substance NNS cord-021413-1ht1xm88 338 11 ( ( -LRB- cord-021413-1ht1xm88 338 12 antibodies antibody NNS cord-021413-1ht1xm88 338 13 included include VBD cord-021413-1ht1xm88 338 14 ) ) -RRB- cord-021413-1ht1xm88 338 15 in in IN cord-021413-1ht1xm88 338 16 most most JJS cord-021413-1ht1xm88 338 17 mamma mamma NNP cord-021413-1ht1xm88 338 18 lian lian NNP cord-021413-1ht1xm88 338 19 species specie NNS cord-021413-1ht1xm88 338 20 precluded preclude VBD cord-021413-1ht1xm88 338 21 accurate accurate JJ cord-021413-1ht1xm88 338 22 work work NN cord-021413-1ht1xm88 338 23 . . . cord-021413-1ht1xm88 339 1 They -PRON- PRP cord-021413-1ht1xm88 339 2 therefore therefore RB cord-021413-1ht1xm88 339 3 used use VBD cord-021413-1ht1xm88 339 4 domestic domestic JJ cord-021413-1ht1xm88 339 5 geese goose NNS cord-021413-1ht1xm88 339 6 , , , cord-021413-1ht1xm88 339 7 in in IN cord-021413-1ht1xm88 339 8 which which WDT cord-021413-1ht1xm88 339 9 virtually virtually RB cord-021413-1ht1xm88 339 10 no no DT cord-021413-1ht1xm88 339 11 hemagglutinafion hemagglutinafion NN cord-021413-1ht1xm88 339 12 inhibi inhibi NNP cord-021413-1ht1xm88 339 13 tion tion NN cord-021413-1ht1xm88 339 14 or or CC cord-021413-1ht1xm88 339 15 neutralizing neutralize VBG cord-021413-1ht1xm88 339 16 antibodies antibody NNS cord-021413-1ht1xm88 339 17 could could MD cord-021413-1ht1xm88 339 18 be be VB cord-021413-1ht1xm88 339 19 detected detect VBN cord-021413-1ht1xm88 339 20 prior prior RB cord-021413-1ht1xm88 339 21 to to IN cord-021413-1ht1xm88 339 22 i -PRON- PRP cord-021413-1ht1xm88 339 23 m be VBP cord-021413-1ht1xm88 339 24 munization munization NNP cord-021413-1ht1xm88 339 25 . . . cord-021413-1ht1xm88 340 1 In in IN cord-021413-1ht1xm88 340 2 any any DT cord-021413-1ht1xm88 340 3 event event NN cord-021413-1ht1xm88 340 4 , , , cord-021413-1ht1xm88 340 5 for for IN cord-021413-1ht1xm88 340 6 routine routine JJ cord-021413-1ht1xm88 340 7 surveillance surveillance NN cord-021413-1ht1xm88 340 8 , , , cord-021413-1ht1xm88 340 9 the the DT cord-021413-1ht1xm88 340 10 hemagglutination hemagglutination NN cord-021413-1ht1xm88 340 11 inhibition inhibition NN cord-021413-1ht1xm88 340 12 test test NN cord-021413-1ht1xm88 340 13 is be VBZ cord-021413-1ht1xm88 340 14 currently currently RB cord-021413-1ht1xm88 340 15 utilized utilize VBN cord-021413-1ht1xm88 340 16 . . . cord-021413-1ht1xm88 341 1 Comments comment NNS cord-021413-1ht1xm88 341 2 similar similar JJ cord-021413-1ht1xm88 341 3 to to IN cord-021413-1ht1xm88 341 4 those those DT cord-021413-1ht1xm88 341 5 expressed express VBN cord-021413-1ht1xm88 341 6 for for IN cord-021413-1ht1xm88 341 7 EDIM EDIM NNP cord-021413-1ht1xm88 341 8 virus virus NN cord-021413-1ht1xm88 341 9 recov recov NN cord-021413-1ht1xm88 341 10 ery ery JJ cord-021413-1ht1xm88 341 11 and and CC cord-021413-1ht1xm88 341 12 visualization visualization NN cord-021413-1ht1xm88 341 13 apply apply NN cord-021413-1ht1xm88 341 14 . . . cord-021413-1ht1xm88 342 1 Although although IN cord-021413-1ht1xm88 342 2 it -PRON- PRP cord-021413-1ht1xm88 342 3 is be VBZ cord-021413-1ht1xm88 342 4 possible possible JJ cord-021413-1ht1xm88 342 5 to to TO cord-021413-1ht1xm88 342 6 perform perform VB cord-021413-1ht1xm88 342 7 these these DT cord-021413-1ht1xm88 342 8 procedures procedure NNS cord-021413-1ht1xm88 342 9 , , , cord-021413-1ht1xm88 342 10 they -PRON- PRP cord-021413-1ht1xm88 342 11 are be VBP cord-021413-1ht1xm88 342 12 inefficient inefficient JJ cord-021413-1ht1xm88 342 13 for for IN cord-021413-1ht1xm88 342 14 routine routine JJ cord-021413-1ht1xm88 342 15 diagnostic diagnostic JJ cord-021413-1ht1xm88 342 16 puφoses puφose NNS cord-021413-1ht1xm88 342 17 . . . cord-021413-1ht1xm88 343 1 Stanley Stanley NNP cord-021413-1ht1xm88 343 2 ( ( -LRB- cord-021413-1ht1xm88 343 3 1977 1977 CD cord-021413-1ht1xm88 343 4 ) ) -RRB- cord-021413-1ht1xm88 343 5 has have VBZ cord-021413-1ht1xm88 343 6 outlined outline VBN cord-021413-1ht1xm88 343 7 methods method NNS cord-021413-1ht1xm88 343 8 for for IN cord-021413-1ht1xm88 343 9 this this DT cord-021413-1ht1xm88 343 10 pur pur NN cord-021413-1ht1xm88 343 11 pose pose NNP cord-021413-1ht1xm88 343 12 . . . cord-021413-1ht1xm88 344 1 In in IN cord-021413-1ht1xm88 344 2 brief brief JJ cord-021413-1ht1xm88 344 3 , , , cord-021413-1ht1xm88 344 4 infectious infectious JJ cord-021413-1ht1xm88 344 5 material material NN cord-021413-1ht1xm88 344 6 can can MD cord-021413-1ht1xm88 344 7 be be VB cord-021413-1ht1xm88 344 8 inoculated inoculate VBN cord-021413-1ht1xm88 344 9 into into IN cord-021413-1ht1xm88 344 10 tissue tissue NN cord-021413-1ht1xm88 344 11 cultures culture NNS cord-021413-1ht1xm88 344 12 ( ( -LRB- cord-021413-1ht1xm88 344 13 primary primary JJ cord-021413-1ht1xm88 344 14 rhesus rhesus NNP cord-021413-1ht1xm88 344 15 monkey monkey NN cord-021413-1ht1xm88 344 16 or or CC cord-021413-1ht1xm88 344 17 human human JJ cord-021413-1ht1xm88 344 18 kidney kidney NN cord-021413-1ht1xm88 344 19 ) ) -RRB- cord-021413-1ht1xm88 344 20 or or CC cord-021413-1ht1xm88 344 21 newbom newbom NNP cord-021413-1ht1xm88 344 22 mice mouse NNS cord-021413-1ht1xm88 344 23 ( ( -LRB- cord-021413-1ht1xm88 344 24 from from IN cord-021413-1ht1xm88 344 25 reovirus reovirus NNP cord-021413-1ht1xm88 344 26 3 3 CD cord-021413-1ht1xm88 344 27 free free JJ cord-021413-1ht1xm88 344 28 colonies colony NNS cord-021413-1ht1xm88 344 29 ! ! . cord-021413-1ht1xm88 344 30 ) ) -RRB- cord-021413-1ht1xm88 344 31 , , , cord-021413-1ht1xm88 344 32 or or CC cord-021413-1ht1xm88 344 33 the the DT cord-021413-1ht1xm88 344 34 material material NN cord-021413-1ht1xm88 344 35 may may MD cord-021413-1ht1xm88 344 36 be be VB cord-021413-1ht1xm88 344 37 subjected subject VBN cord-021413-1ht1xm88 344 38 to to IN cord-021413-1ht1xm88 344 39 immunofluorescent immunofluorescent JJ cord-021413-1ht1xm88 344 40 methods method NNS cord-021413-1ht1xm88 344 41 . . . cord-021413-1ht1xm88 345 1 An an DT cord-021413-1ht1xm88 345 2 im- im- JJ cord-021413-1ht1xm88 345 3 Cesarean cesarean JJ cord-021413-1ht1xm88 345 4 derivation derivation NN cord-021413-1ht1xm88 345 5 and and CC cord-021413-1ht1xm88 345 6 barrier barrier NN cord-021413-1ht1xm88 345 7 maintenance maintenance NN cord-021413-1ht1xm88 345 8 are be VBP cord-021413-1ht1xm88 345 9 believed believe VBN cord-021413-1ht1xm88 345 10 to to TO cord-021413-1ht1xm88 345 11 be be VB cord-021413-1ht1xm88 345 12 suitable suitable JJ cord-021413-1ht1xm88 345 13 techniques technique NNS cord-021413-1ht1xm88 345 14 for for IN cord-021413-1ht1xm88 345 15 control control NN cord-021413-1ht1xm88 345 16 and and CC cord-021413-1ht1xm88 345 17 prevention prevention NN cord-021413-1ht1xm88 345 18 of of IN cord-021413-1ht1xm88 345 19 reovirus reovirus NNP cord-021413-1ht1xm88 345 20 3 3 CD cord-021413-1ht1xm88 345 21 infection infection NN cord-021413-1ht1xm88 345 22 . . . cord-021413-1ht1xm88 346 1 Although although IN cord-021413-1ht1xm88 346 2 no no DT cord-021413-1ht1xm88 346 3 experimental experimental JJ cord-021413-1ht1xm88 346 4 evidence evidence NN cord-021413-1ht1xm88 346 5 has have VBZ cord-021413-1ht1xm88 346 6 been be VBN cord-021413-1ht1xm88 346 7 found find VBN cord-021413-1ht1xm88 346 8 , , , cord-021413-1ht1xm88 346 9 it -PRON- PRP cord-021413-1ht1xm88 346 10 is be VBZ cord-021413-1ht1xm88 346 11 possible possible JJ cord-021413-1ht1xm88 346 12 that that IN cord-021413-1ht1xm88 346 13 the the DT cord-021413-1ht1xm88 346 14 use use NN cord-021413-1ht1xm88 346 15 of of IN cord-021413-1ht1xm88 346 16 filter filter NN cord-021413-1ht1xm88 346 17 devices device NNS cord-021413-1ht1xm88 346 18 in in IN cord-021413-1ht1xm88 346 19 conventional conventional JJ cord-021413-1ht1xm88 346 20 colonies colony NNS cord-021413-1ht1xm88 346 21 might may MD cord-021413-1ht1xm88 346 22 also also RB cord-021413-1ht1xm88 346 23 be be VB cord-021413-1ht1xm88 346 24 helpful helpful JJ cord-021413-1ht1xm88 346 25 in in IN cord-021413-1ht1xm88 346 26 preventing prevent VBG cord-021413-1ht1xm88 346 27 the the DT cord-021413-1ht1xm88 346 28 spread spread NN cord-021413-1ht1xm88 346 29 of of IN cord-021413-1ht1xm88 346 30 infection infection NN cord-021413-1ht1xm88 346 31 . . . cord-021413-1ht1xm88 347 1 In in IN cord-021413-1ht1xm88 347 2 the the DT cord-021413-1ht1xm88 347 3 absence absence NN cord-021413-1ht1xm88 347 4 of of IN cord-021413-1ht1xm88 347 5 information information NN cord-021413-1ht1xm88 347 6 on on IN cord-021413-1ht1xm88 347 7 the the DT cord-021413-1ht1xm88 347 8 vertical vertical JJ cord-021413-1ht1xm88 347 9 trans trans NNP cord-021413-1ht1xm88 347 10 mission mission NN cord-021413-1ht1xm88 347 11 of of IN cord-021413-1ht1xm88 347 12 the the DT cord-021413-1ht1xm88 347 13 agent agent NN cord-021413-1ht1xm88 347 14 , , , cord-021413-1ht1xm88 347 15 it -PRON- PRP cord-021413-1ht1xm88 347 16 is be VBZ cord-021413-1ht1xm88 347 17 impossible impossible JJ cord-021413-1ht1xm88 347 18 to to TO cord-021413-1ht1xm88 347 19 evaluate evaluate VB cord-021413-1ht1xm88 347 20 the the DT cord-021413-1ht1xm88 347 21 influence influence NN cord-021413-1ht1xm88 347 22 of of IN cord-021413-1ht1xm88 347 23 that that DT cord-021413-1ht1xm88 347 24 route route NN cord-021413-1ht1xm88 347 25 on on IN cord-021413-1ht1xm88 347 26 successful successful JJ cord-021413-1ht1xm88 347 27 control control NN cord-021413-1ht1xm88 347 28 of of IN cord-021413-1ht1xm88 347 29 the the DT cord-021413-1ht1xm88 347 30 endemic endemic JJ cord-021413-1ht1xm88 347 31 disease disease NN cord-021413-1ht1xm88 347 32 . . . cord-021413-1ht1xm88 348 1 Although although IN cord-021413-1ht1xm88 348 2 therapy therapy NN cord-021413-1ht1xm88 348 3 is be VBZ cord-021413-1ht1xm88 348 4 impractical impractical JJ cord-021413-1ht1xm88 348 5 from from IN cord-021413-1ht1xm88 348 6 the the DT cord-021413-1ht1xm88 348 7 standpoint standpoint NN cord-021413-1ht1xm88 348 8 of of IN cord-021413-1ht1xm88 348 9 con con NN cord-021413-1ht1xm88 348 10 trolling troll VBG cord-021413-1ht1xm88 348 11 epizootics epizootic NNS cord-021413-1ht1xm88 348 12 of of IN cord-021413-1ht1xm88 348 13 reovirus reovirus NNP cord-021413-1ht1xm88 348 14 infection infection NN cord-021413-1ht1xm88 348 15 , , , cord-021413-1ht1xm88 348 16 it -PRON- PRP cord-021413-1ht1xm88 348 17 is be VBZ cord-021413-1ht1xm88 348 18 nonetheless nonetheless RB cord-021413-1ht1xm88 348 19 of of IN cord-021413-1ht1xm88 348 20 considerable considerable JJ cord-021413-1ht1xm88 348 21 interest interest NN cord-021413-1ht1xm88 348 22 that that WDT cord-021413-1ht1xm88 348 23 Willey Willey NNP cord-021413-1ht1xm88 348 24 and and CC cord-021413-1ht1xm88 348 25 Ushijima Ushijima NNP cord-021413-1ht1xm88 348 26 ( ( -LRB- cord-021413-1ht1xm88 348 27 1980 1980 CD cord-021413-1ht1xm88 348 28 ) ) -RRB- cord-021413-1ht1xm88 348 29 found find VBD cord-021413-1ht1xm88 348 30 that that IN cord-021413-1ht1xm88 348 31 thymosin thymosin NN cord-021413-1ht1xm88 348 32 given give VBN cord-021413-1ht1xm88 348 33 intraperitoneally intraperitoneally RB cord-021413-1ht1xm88 348 34 to to IN cord-021413-1ht1xm88 348 35 7-day 7-day JJ cord-021413-1ht1xm88 348 36 - - HYPH cord-021413-1ht1xm88 348 37 old old JJ cord-021413-1ht1xm88 348 38 mice mouse NNS cord-021413-1ht1xm88 348 39 that that WDT cord-021413-1ht1xm88 348 40 had have VBD cord-021413-1ht1xm88 348 41 been be VBN cord-021413-1ht1xm88 348 42 neonatally neonatally RB cord-021413-1ht1xm88 348 43 infected infect VBN cord-021413-1ht1xm88 348 44 with with IN cord-021413-1ht1xm88 348 45 reovirus reovirus NNP cord-021413-1ht1xm88 348 46 2 2 CD cord-021413-1ht1xm88 348 47 ( ( -LRB- cord-021413-1ht1xm88 348 48 2 2 CD cord-021413-1ht1xm88 348 49 LD50 LD50 NNP cord-021413-1ht1xm88 348 50 ) ) -RRB- cord-021413-1ht1xm88 348 51 signifi signifi NNP cord-021413-1ht1xm88 348 52 cantly cantly RB cord-021413-1ht1xm88 348 53 increased increase VBD cord-021413-1ht1xm88 348 54 their -PRON- PRP$ cord-021413-1ht1xm88 348 55 mean mean JJ cord-021413-1ht1xm88 348 56 survival survival NN cord-021413-1ht1xm88 348 57 time time NN cord-021413-1ht1xm88 348 58 , , , cord-021413-1ht1xm88 348 59 provided provide VBD cord-021413-1ht1xm88 348 60 it -PRON- PRP cord-021413-1ht1xm88 348 61 was be VBD cord-021413-1ht1xm88 348 62 ad ad NN cord-021413-1ht1xm88 348 63 ministered minister VBD cord-021413-1ht1xm88 348 64 at at IN cord-021413-1ht1xm88 348 65 2200 2200 CD cord-021413-1ht1xm88 348 66 hr hr NN cord-021413-1ht1xm88 348 67 . . . cord-021413-1ht1xm88 349 1 When when WRB cord-021413-1ht1xm88 349 2 given give VBN cord-021413-1ht1xm88 349 3 at at IN cord-021413-1ht1xm88 349 4 0800 0800 CD cord-021413-1ht1xm88 349 5 hr hr NN cord-021413-1ht1xm88 349 6 , , , cord-021413-1ht1xm88 349 7 significantly significantly RB cord-021413-1ht1xm88 349 8 increased increase VBN cord-021413-1ht1xm88 349 9 survival survival NN cord-021413-1ht1xm88 349 10 time time NN cord-021413-1ht1xm88 349 11 was be VBD cord-021413-1ht1xm88 349 12 not not RB cord-021413-1ht1xm88 349 13 observed observe VBN cord-021413-1ht1xm88 349 14 , , , cord-021413-1ht1xm88 349 15 but but CC cord-021413-1ht1xm88 349 16 when when WRB cord-021413-1ht1xm88 349 17 inoculated inoculate VBN cord-021413-1ht1xm88 349 18 at at IN cord-021413-1ht1xm88 349 19 1200 1200 CD cord-021413-1ht1xm88 349 20 hr hr NN cord-021413-1ht1xm88 349 21 , , , cord-021413-1ht1xm88 349 22 there there EX cord-021413-1ht1xm88 349 23 was be VBD cord-021413-1ht1xm88 349 24 an an DT cord-021413-1ht1xm88 349 25 apparent apparent JJ cord-021413-1ht1xm88 349 26 decrease decrease NN cord-021413-1ht1xm88 349 27 in in IN cord-021413-1ht1xm88 349 28 mean mean JJ cord-021413-1ht1xm88 349 29 survival survival NN cord-021413-1ht1xm88 349 30 time time NN cord-021413-1ht1xm88 349 31 . . . cord-021413-1ht1xm88 350 1 Reviews review NNS cord-021413-1ht1xm88 350 2 on on IN cord-021413-1ht1xm88 350 3 the the DT cord-021413-1ht1xm88 350 4 subject subject NN cord-021413-1ht1xm88 350 5 include include VBP cord-021413-1ht1xm88 350 6 those those DT cord-021413-1ht1xm88 350 7 by by IN cord-021413-1ht1xm88 350 8 Piazza Piazza NNP cord-021413-1ht1xm88 350 9 ( ( -LRB- cord-021413-1ht1xm88 350 10 1969 1969 CD cord-021413-1ht1xm88 350 11 ) ) -RRB- cord-021413-1ht1xm88 350 12 , , , cord-021413-1ht1xm88 350 13 Mcintosh Mcintosh NNP cord-021413-1ht1xm88 350 14 ( ( -LRB- cord-021413-1ht1xm88 350 15 1977 1977 CD cord-021413-1ht1xm88 350 16 ) ) -RRB- cord-021413-1ht1xm88 350 17 , , , cord-021413-1ht1xm88 350 18 Kapikian Kapikian NNP cord-021413-1ht1xm88 350 19 ( ( -LRB- cord-021413-1ht1xm88 350 20 1975 1975 CD cord-021413-1ht1xm88 350 21 ) ) -RRB- cord-021413-1ht1xm88 350 22 , , , cord-021413-1ht1xm88 350 23 Andrewes Andrewes NNP cord-021413-1ht1xm88 350 24 et et FW cord-021413-1ht1xm88 350 25 aL aL NNP cord-021413-1ht1xm88 350 26 ( ( -LRB- cord-021413-1ht1xm88 350 27 1978 1978 CD cord-021413-1ht1xm88 350 28 ) ) -RRB- cord-021413-1ht1xm88 350 29 , , , cord-021413-1ht1xm88 350 30 Holmes Holmes NNP cord-021413-1ht1xm88 350 31 ( ( -LRB- cord-021413-1ht1xm88 350 32 1979 1979 CD cord-021413-1ht1xm88 350 33 ) ) -RRB- cord-021413-1ht1xm88 350 34 , , , cord-021413-1ht1xm88 350 35 Garwes Garwes NNP cord-021413-1ht1xm88 350 36 ( ( -LRB- cord-021413-1ht1xm88 350 37 1979 1979 CD cord-021413-1ht1xm88 350 38 ) ) -RRB- cord-021413-1ht1xm88 350 39 , , , cord-021413-1ht1xm88 350 40 and and CC cord-021413-1ht1xm88 350 41 Robb Robb NNP cord-021413-1ht1xm88 350 42 and and CC cord-021413-1ht1xm88 350 43 Bond Bond NNP cord-021413-1ht1xm88 350 44 ( ( -LRB- cord-021413-1ht1xm88 350 45 1980 1980 CD cord-021413-1ht1xm88 350 46 ) ) -RRB- cord-021413-1ht1xm88 350 47 . . . cord-021413-1ht1xm88 351 1 Based base VBN cord-021413-1ht1xm88 351 2 on on IN cord-021413-1ht1xm88 351 3 their -PRON- PRP$ cord-021413-1ht1xm88 351 4 own own JJ cord-021413-1ht1xm88 351 5 electron electron NN cord-021413-1ht1xm88 351 6 microscopic microscopic JJ cord-021413-1ht1xm88 351 7 studies study NNS cord-021413-1ht1xm88 351 8 and and CC cord-021413-1ht1xm88 351 9 on on IN cord-021413-1ht1xm88 351 10 those those DT cord-021413-1ht1xm88 351 11 of of IN cord-021413-1ht1xm88 351 12 David David NNP cord-021413-1ht1xm88 351 13 - - HYPH cord-021413-1ht1xm88 351 14 Ferreira Ferreira NNP cord-021413-1ht1xm88 351 15 and and CC cord-021413-1ht1xm88 351 16 Manaker Manaker NNP cord-021413-1ht1xm88 351 17 ( ( -LRB- cord-021413-1ht1xm88 351 18 1965 1965 CD cord-021413-1ht1xm88 351 19 ) ) -RRB- cord-021413-1ht1xm88 351 20 , , , cord-021413-1ht1xm88 351 21 Becker Becker NNP cord-021413-1ht1xm88 351 22 et et NNP cord-021413-1ht1xm88 351 23 aL aL NNP cord-021413-1ht1xm88 351 24 ( ( -LRB- cord-021413-1ht1xm88 351 25 1967 1967 CD cord-021413-1ht1xm88 351 26 ) ) -RRB- cord-021413-1ht1xm88 351 27 considered consider VBN cord-021413-1ht1xm88 351 28 that that IN cord-021413-1ht1xm88 351 29 MHV MHV NNP cord-021413-1ht1xm88 351 30 might may MD cord-021413-1ht1xm88 351 31 be be VB cord-021413-1ht1xm88 351 32 an an DT cord-021413-1ht1xm88 351 33 ' ' `` cord-021413-1ht1xm88 351 34 TBV tbv NN cord-021413-1ht1xm88 351 35 - - HYPH cord-021413-1ht1xm88 351 36 like like JJ cord-021413-1ht1xm88 351 37 " " '' cord-021413-1ht1xm88 351 38 ( ( -LRB- cord-021413-1ht1xm88 351 39 infecti infecti JJ cord-021413-1ht1xm88 351 40 ous ous JJ cord-021413-1ht1xm88 351 41 bronchitis bronchitis NNP cord-021413-1ht1xm88 351 42 viruslike viruslike NNP cord-021413-1ht1xm88 351 43 ) ) -RRB- cord-021413-1ht1xm88 351 44 agent agent NN cord-021413-1ht1xm88 351 45 . . . cord-021413-1ht1xm88 352 1 Virions virion NNS cord-021413-1ht1xm88 352 2 of of IN cord-021413-1ht1xm88 352 3 similar similar JJ cord-021413-1ht1xm88 352 4 moφhology moφhology NN cord-021413-1ht1xm88 352 5 seen see VBN cord-021413-1ht1xm88 352 6 in in IN cord-021413-1ht1xm88 352 7 electron electron NN cord-021413-1ht1xm88 352 8 micrographs micrograph NNS cord-021413-1ht1xm88 352 9 and and CC cord-021413-1ht1xm88 352 10 also also RB cord-021413-1ht1xm88 352 11 ether ether NN cord-021413-1ht1xm88 352 12 sensitive sensitive JJ cord-021413-1ht1xm88 352 13 , , , cord-021413-1ht1xm88 352 14 as as IN cord-021413-1ht1xm88 352 15 is be VBZ cord-021413-1ht1xm88 352 16 IBV IBV NNP cord-021413-1ht1xm88 352 17 , , , cord-021413-1ht1xm88 352 18 were be VBD cord-021413-1ht1xm88 352 19 being be VBG cord-021413-1ht1xm88 352 20 isolated isolate VBN cord-021413-1ht1xm88 352 21 at at IN cord-021413-1ht1xm88 352 22 that that DT cord-021413-1ht1xm88 352 23 time time NN cord-021413-1ht1xm88 352 24 from from IN cord-021413-1ht1xm88 352 25 human human JJ cord-021413-1ht1xm88 352 26 cases case NNS cord-021413-1ht1xm88 352 27 of of IN cord-021413-1ht1xm88 352 28 colds cold NNS cord-021413-1ht1xm88 352 29 ( ( -LRB- cord-021413-1ht1xm88 352 30 Almeida Almeida NNP cord-021413-1ht1xm88 352 31 and and CC cord-021413-1ht1xm88 352 32 Tyrell Tyrell NNP cord-021413-1ht1xm88 352 33 , , , cord-021413-1ht1xm88 352 34 1967 1967 CD cord-021413-1ht1xm88 352 35 ) ) -RRB- cord-021413-1ht1xm88 352 36 . . . cord-021413-1ht1xm88 353 1 The the DT cord-021413-1ht1xm88 353 2 following following JJ cord-021413-1ht1xm88 353 3 year year NN cord-021413-1ht1xm88 353 4 , , , cord-021413-1ht1xm88 353 5 the the DT cord-021413-1ht1xm88 353 6 term term NN cord-021413-1ht1xm88 353 7 Coronavirus Coronavirus NNP cord-021413-1ht1xm88 353 8 was be VBD cord-021413-1ht1xm88 353 9 proposed propose VBN cord-021413-1ht1xm88 353 10 for for IN cord-021413-1ht1xm88 353 11 the the DT cord-021413-1ht1xm88 353 12 group group NN cord-021413-1ht1xm88 353 13 ( ( -LRB- cord-021413-1ht1xm88 353 14 Tyrell Tyrell NNP cord-021413-1ht1xm88 353 15 et et NNP cord-021413-1ht1xm88 353 16 aL aL NNP cord-021413-1ht1xm88 353 17 , , , cord-021413-1ht1xm88 353 18 1968 1968 CD cord-021413-1ht1xm88 353 19 ) ) -RRB- cord-021413-1ht1xm88 353 20 , , , cord-021413-1ht1xm88 353 21 and and CC cord-021413-1ht1xm88 353 22 in in IN cord-021413-1ht1xm88 353 23 1975 1975 CD cord-021413-1ht1xm88 353 24 the the DT cord-021413-1ht1xm88 353 25 Coronaviridae Coronaviridae NNP cord-021413-1ht1xm88 353 26 became become VBD cord-021413-1ht1xm88 353 27 an an DT cord-021413-1ht1xm88 353 28 official official JJ cord-021413-1ht1xm88 353 29 fam fam NN cord-021413-1ht1xm88 353 30 ily ily UH cord-021413-1ht1xm88 353 31 with with IN cord-021413-1ht1xm88 353 32 a a DT cord-021413-1ht1xm88 353 33 single single JJ cord-021413-1ht1xm88 353 34 genus genus NN cord-021413-1ht1xm88 353 35 , , , cord-021413-1ht1xm88 353 36 Coronavirus Coronavirus NNP cord-021413-1ht1xm88 353 37 ( ( -LRB- cord-021413-1ht1xm88 353 38 Tyrell Tyrell NNP cord-021413-1ht1xm88 353 39 etaL etaL NNP cord-021413-1ht1xm88 353 40 , , , cord-021413-1ht1xm88 353 41 1975 1975 CD cord-021413-1ht1xm88 353 42 Additional additional JJ cord-021413-1ht1xm88 353 43 agents agent NNS cord-021413-1ht1xm88 353 44 may may MD cord-021413-1ht1xm88 353 45 be be VB cord-021413-1ht1xm88 353 46 added add VBN cord-021413-1ht1xm88 353 47 to to IN cord-021413-1ht1xm88 353 48 this this DT cord-021413-1ht1xm88 353 49 group group NN cord-021413-1ht1xm88 353 50 , , , cord-021413-1ht1xm88 353 51 e.g. e.g. RB cord-021413-1ht1xm88 353 52 , , , cord-021413-1ht1xm88 353 53 ' ' '' cord-021413-1ht1xm88 353 54 ' ' `` cord-021413-1ht1xm88 353 55 runde runde VBN cord-021413-1ht1xm88 353 56 " " '' cord-021413-1ht1xm88 353 57 virus virus NN cord-021413-1ht1xm88 353 58 ( ( -LRB- cord-021413-1ht1xm88 353 59 Traavik Traavik NNP cord-021413-1ht1xm88 353 60 et et NNP cord-021413-1ht1xm88 353 61 aL aL NNP cord-021413-1ht1xm88 353 62 , , , cord-021413-1ht1xm88 353 63 1977 1977 CD cord-021413-1ht1xm88 353 64 ) ) -RRB- cord-021413-1ht1xm88 353 65 , , , cord-021413-1ht1xm88 353 66 a a DT cord-021413-1ht1xm88 353 67 Coronavirus Coronavirus NNP cord-021413-1ht1xm88 353 68 causing cause VBG cord-021413-1ht1xm88 353 69 car car NN cord-021413-1ht1xm88 353 70 diomyopathy diomyopathy NNS cord-021413-1ht1xm88 353 71 in in IN cord-021413-1ht1xm88 353 72 rabbits rabbit NNS cord-021413-1ht1xm88 353 73 ( ( -LRB- cord-021413-1ht1xm88 353 74 Small Small NNP cord-021413-1ht1xm88 353 75 et et NNP cord-021413-1ht1xm88 353 76 aL aL NNP cord-021413-1ht1xm88 353 77 , , , cord-021413-1ht1xm88 353 78 1979 1979 CD cord-021413-1ht1xm88 353 79 ) ) -RRB- cord-021413-1ht1xm88 353 80 . . . cord-021413-1ht1xm88 354 1 As as IN cord-021413-1ht1xm88 354 2 noted note VBN cord-021413-1ht1xm88 354 3 , , , cord-021413-1ht1xm88 354 4 many many JJ cord-021413-1ht1xm88 354 5 strains strain NNS cord-021413-1ht1xm88 354 6 of of IN cord-021413-1ht1xm88 354 7 MHV MHV NNP cord-021413-1ht1xm88 354 8 have have VBP cord-021413-1ht1xm88 354 9 been be VBN cord-021413-1ht1xm88 354 10 recovered recover VBN cord-021413-1ht1xm88 354 11 from from IN cord-021413-1ht1xm88 354 12 mice mouse NNS cord-021413-1ht1xm88 354 13 under under IN cord-021413-1ht1xm88 354 14 various various JJ cord-021413-1ht1xm88 354 15 circumstances circumstance NNS cord-021413-1ht1xm88 354 16 . . . cord-021413-1ht1xm88 355 1 In in IN cord-021413-1ht1xm88 355 2 addition addition NN cord-021413-1ht1xm88 355 3 to to IN cord-021413-1ht1xm88 355 4 JHM JHM NNP cord-021413-1ht1xm88 355 5 , , , cord-021413-1ht1xm88 355 6 these these DT cord-021413-1ht1xm88 355 7 include include VBP cord-021413-1ht1xm88 355 8 : : : cord-021413-1ht1xm88 355 9 MHVl MHVl NNS cord-021413-1ht1xm88 355 10 , , , cord-021413-1ht1xm88 355 11 from from IN cord-021413-1ht1xm88 355 12 " " `` cord-021413-1ht1xm88 355 13 white white JJ cord-021413-1ht1xm88 355 14 mice mouse NNS cord-021413-1ht1xm88 355 15 " " '' cord-021413-1ht1xm88 355 16 ( ( -LRB- cord-021413-1ht1xm88 355 17 P p NN cord-021413-1ht1xm88 355 18 or or CC cord-021413-1ht1xm88 355 19 Parkes Parkes NNP cord-021413-1ht1xm88 355 20 strain strain NN cord-021413-1ht1xm88 355 21 ) ) -RRB- cord-021413-1ht1xm88 355 22 , , , cord-021413-1ht1xm88 355 23 dur dur FW cord-021413-1ht1xm88 355 24 ing e VBG cord-021413-1ht1xm88 355 25 attempts attempt NNS cord-021413-1ht1xm88 355 26 to to TO cord-021413-1ht1xm88 355 27 adapt adapt VB cord-021413-1ht1xm88 355 28 human human JJ cord-021413-1ht1xm88 355 29 hepatitis hepatitis NN cord-021413-1ht1xm88 355 30 virus virus NN cord-021413-1ht1xm88 355 31 to to IN cord-021413-1ht1xm88 355 32 animals animal NNS cord-021413-1ht1xm88 355 33 ( ( -LRB- cord-021413-1ht1xm88 355 34 the the DT cord-021413-1ht1xm88 355 35 strain strain NN cord-021413-1ht1xm88 355 36 was be VBD cord-021413-1ht1xm88 355 37 originally originally RB cord-021413-1ht1xm88 355 38 isolated isolate VBN cord-021413-1ht1xm88 355 39 as as IN cord-021413-1ht1xm88 355 40 a a DT cord-021413-1ht1xm88 355 41 dual dual JJ cord-021413-1ht1xm88 355 42 agent agent NN cord-021413-1ht1xm88 355 43 consisting consist VBG cord-021413-1ht1xm88 355 44 of of IN cord-021413-1ht1xm88 355 45 the the DT cord-021413-1ht1xm88 355 46 virus virus NN cord-021413-1ht1xm88 355 47 and and CC cord-021413-1ht1xm88 355 48 a a DT cord-021413-1ht1xm88 355 49 protozoon protozoon NN cord-021413-1ht1xm88 355 50 parasite parasite NN cord-021413-1ht1xm88 355 51 , , , cord-021413-1ht1xm88 355 52 Eperythrozoon Eperythrozoon NNP cord-021413-1ht1xm88 355 53 coccoides coccoides NNP cord-021413-1ht1xm88 355 54 ( ( -LRB- cord-021413-1ht1xm88 355 55 Gledhill Gledhill NNP cord-021413-1ht1xm88 355 56 and and CC cord-021413-1ht1xm88 355 57 Andrewes Andrewes NNP cord-021413-1ht1xm88 355 58 , , , cord-021413-1ht1xm88 355 59 1951 1951 CD cord-021413-1ht1xm88 355 60 ) ) -RRB- cord-021413-1ht1xm88 355 61 ; ; : cord-021413-1ht1xm88 355 62 MHV2 MHV2 NNP cord-021413-1ht1xm88 355 63 , , , cord-021413-1ht1xm88 355 64 from from IN cord-021413-1ht1xm88 355 65 mice mouse NNS cord-021413-1ht1xm88 355 66 used use VBN cord-021413-1ht1xm88 355 67 to to TO cord-021413-1ht1xm88 355 68 propagate propagate VB cord-021413-1ht1xm88 355 69 murine murine JJ cord-021413-1ht1xm88 355 70 leukemia leukemia NN cord-021413-1ht1xm88 355 71 virus virus NN cord-021413-1ht1xm88 355 72 ( ( -LRB- cord-021413-1ht1xm88 355 73 Nelson Nelson NNP cord-021413-1ht1xm88 355 74 , , , cord-021413-1ht1xm88 355 75 1952a 1952a CD cord-021413-1ht1xm88 355 76 , , , cord-021413-1ht1xm88 355 77 b b LS cord-021413-1ht1xm88 355 78 ) ) -RRB- cord-021413-1ht1xm88 355 79 ; ; : cord-021413-1ht1xm88 355 80 MHV3 MHV3 NNP cord-021413-1ht1xm88 355 81 , , , cord-021413-1ht1xm88 355 82 also also RB cord-021413-1ht1xm88 355 83 found find VBD cord-021413-1ht1xm88 355 84 during during IN cord-021413-1ht1xm88 355 85 studies study NNS cord-021413-1ht1xm88 355 86 on on IN cord-021413-1ht1xm88 355 87 adaptation adaptation NN cord-021413-1ht1xm88 355 88 of of IN cord-021413-1ht1xm88 355 89 human human JJ cord-021413-1ht1xm88 355 90 hepatitis hepatitis NN cord-021413-1ht1xm88 355 91 virus virus NN cord-021413-1ht1xm88 355 92 to to IN cord-021413-1ht1xm88 355 93 mice mouse NNS cord-021413-1ht1xm88 356 1 ( ( -LRB- cord-021413-1ht1xm88 356 2 Dick Dick NNP cord-021413-1ht1xm88 356 3 et et NNP cord-021413-1ht1xm88 356 4 aL aL NNP cord-021413-1ht1xm88 356 5 , , , cord-021413-1ht1xm88 356 6 1956 1956 CD cord-021413-1ht1xm88 356 7 ) ) -RRB- cord-021413-1ht1xm88 356 8 ; ; : cord-021413-1ht1xm88 356 9 MHV MHV NNP cord-021413-1ht1xm88 356 10 - - HYPH cord-021413-1ht1xm88 356 11 B B NNP cord-021413-1ht1xm88 356 12 ( ( -LRB- cord-021413-1ht1xm88 356 13 EHF-120 EHF-120 NNP cord-021413-1ht1xm88 356 14 ) ) -RRB- cord-021413-1ht1xm88 356 15 , , , cord-021413-1ht1xm88 356 16 from from IN cord-021413-1ht1xm88 356 17 mice mouse NNS cord-021413-1ht1xm88 356 18 used use VBN cord-021413-1ht1xm88 356 19 for for IN cord-021413-1ht1xm88 356 20 human human JJ cord-021413-1ht1xm88 356 21 epidemic epidemic JJ cord-021413-1ht1xm88 356 22 hemorrhagic hemorrhagic JJ cord-021413-1ht1xm88 356 23 fever fever NN cord-021413-1ht1xm88 356 24 ( ( -LRB- cord-021413-1ht1xm88 356 25 HEHF HEHF NNP cord-021413-1ht1xm88 356 26 ) ) -RRB- cord-021413-1ht1xm88 356 27 adaptation adaptation NN cord-021413-1ht1xm88 356 28 attempts attempt NNS cord-021413-1ht1xm88 356 29 ( ( -LRB- cord-021413-1ht1xm88 356 30 Buescher Buescher NNP cord-021413-1ht1xm88 356 31 , , , cord-021413-1ht1xm88 356 32 1952 1952 CD cord-021413-1ht1xm88 356 33 ) ) -RRB- cord-021413-1ht1xm88 356 34 ; ; : cord-021413-1ht1xm88 357 1 an an DT cord-021413-1ht1xm88 357 2 unnamed unnamed JJ cord-021413-1ht1xm88 357 3 strain strain NN cord-021413-1ht1xm88 357 4 from from IN cord-021413-1ht1xm88 357 5 mice mouse NNS cord-021413-1ht1xm88 357 6 undergoing undergo VBG cord-021413-1ht1xm88 357 7 murine murine JJ cord-021413-1ht1xm88 357 8 leukemia leukemia NN cord-021413-1ht1xm88 357 9 chemotherapy chemotherapy NN cord-021413-1ht1xm88 357 10 trials trial NNS cord-021413-1ht1xm88 357 11 ( ( -LRB- cord-021413-1ht1xm88 357 12 Braunsteiner Braunsteiner NNP cord-021413-1ht1xm88 357 13 and and CC cord-021413-1ht1xm88 357 14 Friend Friend NNP cord-021413-1ht1xm88 357 15 , , , cord-021413-1ht1xm88 357 16 1954 1954 CD cord-021413-1ht1xm88 357 17 ) ) -RRB- cord-021413-1ht1xm88 357 18 ; ; : cord-021413-1ht1xm88 357 19 H747 h747 ADD cord-021413-1ht1xm88 357 20 , , , cord-021413-1ht1xm88 357 21 following follow VBG cord-021413-1ht1xm88 357 22 intracere intracere JJ cord-021413-1ht1xm88 357 23 bral bral JJ cord-021413-1ht1xm88 357 24 inoculation inoculation NN cord-021413-1ht1xm88 357 25 of of IN cord-021413-1ht1xm88 357 26 suckling suckle VBG cord-021413-1ht1xm88 357 27 mice mouse NNS cord-021413-1ht1xm88 357 28 with with IN cord-021413-1ht1xm88 357 29 HEHF HEHF NNP cord-021413-1ht1xm88 357 30 materials material NNS cord-021413-1ht1xm88 357 31 ( ( -LRB- cord-021413-1ht1xm88 357 32 Morris Morris NNP cord-021413-1ht1xm88 357 33 , , , cord-021413-1ht1xm88 357 34 1959 1959 CD cord-021413-1ht1xm88 357 35 ) ) -RRB- cord-021413-1ht1xm88 358 1 ; ; : cord-021413-1ht1xm88 358 2 MHV MHV NNP cord-021413-1ht1xm88 358 3 - - HYPH cord-021413-1ht1xm88 358 4 A59 A59 NNP cord-021413-1ht1xm88 358 5 , , , cord-021413-1ht1xm88 358 6 during during IN cord-021413-1ht1xm88 358 7 transfer transfer NN cord-021413-1ht1xm88 358 8 of of IN cord-021413-1ht1xm88 358 9 Moloney Moloney NNP cord-021413-1ht1xm88 358 10 leukemia leukemia NN cord-021413-1ht1xm88 358 11 virus virus NN cord-021413-1ht1xm88 358 12 in in IN cord-021413-1ht1xm88 358 13 mice mouse NNS cord-021413-1ht1xm88 358 14 ( ( -LRB- cord-021413-1ht1xm88 358 15 Manaker Manaker NNP cord-021413-1ht1xm88 358 16 et et NNP cord-021413-1ht1xm88 358 17 aL aL NNP cord-021413-1ht1xm88 358 18 , , , cord-021413-1ht1xm88 358 19 1961 1961 CD cord-021413-1ht1xm88 358 20 ) ) -RRB- cord-021413-1ht1xm88 358 21 ; ; : cord-021413-1ht1xm88 358 22 MHV MHV NNP cord-021413-1ht1xm88 358 23 - - HYPH cord-021413-1ht1xm88 358 24 S S NNP cord-021413-1ht1xm88 358 25 , , , cord-021413-1ht1xm88 358 26 from from IN cord-021413-1ht1xm88 358 27 cesareanderived cesareanderived JJ cord-021413-1ht1xm88 358 28 mice mouse NNS cord-021413-1ht1xm88 358 29 that that WDT cord-021413-1ht1xm88 358 30 had have VBD cord-021413-1ht1xm88 358 31 been be VBN cord-021413-1ht1xm88 358 32 barrier barrier NN cord-021413-1ht1xm88 358 33 - - HYPH cord-021413-1ht1xm88 358 34 maintained maintain VBN cord-021413-1ht1xm88 358 35 before before IN cord-021413-1ht1xm88 358 36 exposure exposure NN cord-021413-1ht1xm88 358 37 to to IN cord-021413-1ht1xm88 358 38 conventional conventional JJ cord-021413-1ht1xm88 358 39 mice mouse NNS cord-021413-1ht1xm88 358 40 ; ; : cord-021413-1ht1xm88 358 41 MHV MHV NNP cord-021413-1ht1xm88 358 42 - - HYPH cord-021413-1ht1xm88 358 43 C C NNP cord-021413-1ht1xm88 358 44 ( ( -LRB- cord-021413-1ht1xm88 358 45 MHV MHV NNP cord-021413-1ht1xm88 358 46 - - HYPH cord-021413-1ht1xm88 358 47 BALB BALB NNP cord-021413-1ht1xm88 358 48 / / SYM cord-021413-1ht1xm88 358 49 c c NN cord-021413-1ht1xm88 358 50 ) ) -RRB- cord-021413-1ht1xm88 358 51 , , , cord-021413-1ht1xm88 358 52 isolated isolate VBN cord-021413-1ht1xm88 358 53 during during IN cord-021413-1ht1xm88 358 54 passage passage NN cord-021413-1ht1xm88 358 55 of of IN cord-021413-1ht1xm88 358 56 spleens spleen NNS cord-021413-1ht1xm88 358 57 from from IN cord-021413-1ht1xm88 358 58 leukemic leukemic JJ cord-021413-1ht1xm88 358 59 mice mouse NNS cord-021413-1ht1xm88 358 60 ( ( -LRB- cord-021413-1ht1xm88 358 61 Nelson Nelson NNP cord-021413-1ht1xm88 358 62 , , , cord-021413-1ht1xm88 358 63 1955 1955 CD cord-021413-1ht1xm88 358 64 ) ) -RRB- cord-021413-1ht1xm88 358 65 ; ; : cord-021413-1ht1xm88 358 66 four four CD cord-021413-1ht1xm88 358 67 addiiional addiiional JJ cord-021413-1ht1xm88 358 68 strains strain NNS cord-021413-1ht1xm88 358 69 from from IN cord-021413-1ht1xm88 358 70 spleens spleen NNS cord-021413-1ht1xm88 358 71 of of IN cord-021413-1ht1xm88 358 72 leukemic leukemic JJ cord-021413-1ht1xm88 358 73 mice mouse NNS cord-021413-1ht1xm88 358 74 or or CC cord-021413-1ht1xm88 358 75 from from IN cord-021413-1ht1xm88 358 76 natural natural JJ cord-021413-1ht1xm88 358 77 outbreaks outbreak NNS cord-021413-1ht1xm88 358 78 ( ( -LRB- cord-021413-1ht1xm88 358 79 MHV mhv NN cord-021413-1ht1xm88 358 80 - - HYPH cord-021413-1ht1xm88 358 81 SRl SRl NNS cord-021413-1ht1xm88 358 82 , , , cord-021413-1ht1xm88 358 83 -SR2 -sr2 NN cord-021413-1ht1xm88 358 84 , , , cord-021413-1ht1xm88 358 85 -SR3 -sr3 NN cord-021413-1ht1xm88 358 86 , , , cord-021413-1ht1xm88 358 87 -SR4 -sr4 ADD cord-021413-1ht1xm88 358 88 ) ) -RRB- cord-021413-1ht1xm88 359 1 ( ( -LRB- cord-021413-1ht1xm88 359 2 Nelson Nelson NNP cord-021413-1ht1xm88 359 3 , , , cord-021413-1ht1xm88 359 4 1963 1963 CD cord-021413-1ht1xm88 359 5 ( ( -LRB- cord-021413-1ht1xm88 359 6 Nelson Nelson NNP cord-021413-1ht1xm88 359 7 , , , cord-021413-1ht1xm88 359 8 , , , cord-021413-1ht1xm88 359 9 1965 1965 CD cord-021413-1ht1xm88 359 10 ; ; , cord-021413-1ht1xm88 359 11 lethal lethal JJ cord-021413-1ht1xm88 359 12 intestinal intestinal JJ cord-021413-1ht1xm88 359 13 virus virus NN cord-021413-1ht1xm88 359 14 of of IN cord-021413-1ht1xm88 359 15 infant infant NN cord-021413-1ht1xm88 359 16 mice mouse NNS cord-021413-1ht1xm88 359 17 ( ( -LRB- cord-021413-1ht1xm88 359 18 LIVIM LIVIM NNP cord-021413-1ht1xm88 359 19 ) ) -RRB- cord-021413-1ht1xm88 359 20 , , , cord-021413-1ht1xm88 359 21 from from IN cord-021413-1ht1xm88 359 22 infant infant NN cord-021413-1ht1xm88 359 23 mice mouse NNS cord-021413-1ht1xm88 359 24 dying die VBG cord-021413-1ht1xm88 359 25 of of IN cord-021413-1ht1xm88 359 26 a a DT cord-021413-1ht1xm88 359 27 spontaneous spontaneous JJ cord-021413-1ht1xm88 359 28 infection infection NN cord-021413-1ht1xm88 359 29 ( ( -LRB- cord-021413-1ht1xm88 359 30 Kraft Kraft NNP cord-021413-1ht1xm88 359 31 , , , cord-021413-1ht1xm88 359 32 1962a 1962a CD cord-021413-1ht1xm88 359 33 ) ) -RRB- cord-021413-1ht1xm88 359 34 , , , cord-021413-1ht1xm88 359 35 identified identify VBN cord-021413-1ht1xm88 359 36 as as IN cord-021413-1ht1xm88 359 37 an an DT cord-021413-1ht1xm88 359 38 MHV MHV NNP cord-021413-1ht1xm88 359 39 strain strain NN cord-021413-1ht1xm88 359 40 by by IN cord-021413-1ht1xm88 359 41 Broderson Broderson NNP cord-021413-1ht1xm88 359 42 et et NNP cord-021413-1ht1xm88 359 43 aL aL NNP cord-021413-1ht1xm88 359 44 ( ( -LRB- cord-021413-1ht1xm88 359 45 1976 1976 CD cord-021413-1ht1xm88 359 46 ) ) -RRB- cord-021413-1ht1xm88 359 47 and and CC cord-021413-1ht1xm88 359 48 Hierholzer Hierholzer NNP cord-021413-1ht1xm88 359 49 et et NNP cord-021413-1ht1xm88 359 50 aL aL NNP cord-021413-1ht1xm88 359 51 ( ( -LRB- cord-021413-1ht1xm88 359 52 1979 1979 CD cord-021413-1ht1xm88 359 53 ) ) -RRB- cord-021413-1ht1xm88 359 54 ; ; : cord-021413-1ht1xm88 359 55 and and CC cord-021413-1ht1xm88 359 56 NuU NuU NNP cord-021413-1ht1xm88 359 57 , , , cord-021413-1ht1xm88 359 58 NuA nua NN cord-021413-1ht1xm88 359 59 , , , cord-021413-1ht1xm88 359 60 Nu66 Nu66 NNP cord-021413-1ht1xm88 359 61 , , , cord-021413-1ht1xm88 359 62 from from IN cord-021413-1ht1xm88 359 63 nude nude JJ cord-021413-1ht1xm88 359 64 mice mouse NNS cord-021413-1ht1xm88 359 65 with with IN cord-021413-1ht1xm88 359 66 hepatitis hepatitis NN cord-021413-1ht1xm88 359 67 and and CC cord-021413-1ht1xm88 359 68 wasting waste VBG cord-021413-1ht1xm88 359 69 syndrome syndrome NN cord-021413-1ht1xm88 359 70 . . . cord-021413-1ht1xm88 360 1 Other other JJ cord-021413-1ht1xm88 360 2 isolates isolate NNS cord-021413-1ht1xm88 360 3 have have VBP cord-021413-1ht1xm88 360 4 also also RB cord-021413-1ht1xm88 360 5 been be VBN cord-021413-1ht1xm88 360 6 derived derive VBN cord-021413-1ht1xm88 360 7 from from IN cord-021413-1ht1xm88 360 8 nude nude JJ cord-021413-1ht1xm88 360 9 mice mouse NNS cord-021413-1ht1xm88 360 10 ( ( -LRB- cord-021413-1ht1xm88 360 11 Sebesteny Sebesteny NNP cord-021413-1ht1xm88 360 12 and and CC cord-021413-1ht1xm88 360 13 Hill Hill NNP cord-021413-1ht1xm88 360 14 , , , cord-021413-1ht1xm88 360 15 1974 1974 CD cord-021413-1ht1xm88 360 16 ; ; : cord-021413-1ht1xm88 360 17 Ward Ward NNP cord-021413-1ht1xm88 360 18 et et NNP cord-021413-1ht1xm88 360 19 aL aL NNP cord-021413-1ht1xm88 360 20 , , , cord-021413-1ht1xm88 360 21 1977 1977 CD cord-021413-1ht1xm88 360 22 ) ) -RRB- cord-021413-1ht1xm88 360 23 , , , cord-021413-1ht1xm88 360 24 and and CC cord-021413-1ht1xm88 360 25 Fox Fox NNP cord-021413-1ht1xm88 360 26 et et FW cord-021413-1ht1xm88 360 27 aL aL NNP cord-021413-1ht1xm88 360 28 ( ( -LRB- cord-021413-1ht1xm88 360 29 1977 1977 CD cord-021413-1ht1xm88 360 30 ) ) -RRB- cord-021413-1ht1xm88 360 31 have have VBP cord-021413-1ht1xm88 360 32 described describe VBN cord-021413-1ht1xm88 360 33 a a DT cord-021413-1ht1xm88 360 34 strain strain NN cord-021413-1ht1xm88 360 35 that that WDT cord-021413-1ht1xm88 360 36 appeared appear VBD cord-021413-1ht1xm88 360 37 during during IN cord-021413-1ht1xm88 360 38 passage passage NN cord-021413-1ht1xm88 360 39 of of IN cord-021413-1ht1xm88 360 40 an an DT cord-021413-1ht1xm88 360 41 ascites ascites NN cord-021413-1ht1xm88 360 42 myeloma myeloma NN cord-021413-1ht1xm88 360 43 cell cell NN cord-021413-1ht1xm88 360 44 line line NN cord-021413-1ht1xm88 360 45 in in IN cord-021413-1ht1xm88 360 46 BALB BALB NNP cord-021413-1ht1xm88 360 47 / / SYM cord-021413-1ht1xm88 360 48 c c NN cord-021413-1ht1xm88 360 49 mice mouse NNS cord-021413-1ht1xm88 360 50 . . . cord-021413-1ht1xm88 361 1 * * NFP cord-021413-1ht1xm88 361 2 HEV HEV NNP cord-021413-1ht1xm88 361 3 may may MD cord-021413-1ht1xm88 361 4 also also RB cord-021413-1ht1xm88 361 5 denote denote VB cord-021413-1ht1xm88 361 6 the the DT cord-021413-1ht1xm88 361 7 hepatoencephalomyelitis hepatoencephalomyelitis NN cord-021413-1ht1xm88 361 8 virus virus NN cord-021413-1ht1xm88 361 9 of of IN cord-021413-1ht1xm88 361 10 Stanley Stanley NNP cord-021413-1ht1xm88 361 11 et et NNP cord-021413-1ht1xm88 361 12 al al NNP cord-021413-1ht1xm88 361 13 . . . cord-021413-1ht1xm88 362 1 ( ( -LRB- cord-021413-1ht1xm88 362 2 1954 1954 CD cord-021413-1ht1xm88 362 3 ) ) -RRB- cord-021413-1ht1xm88 362 4 , , , cord-021413-1ht1xm88 362 5 which which WDT cord-021413-1ht1xm88 362 6 is be VBZ cord-021413-1ht1xm88 362 7 identical identical JJ cord-021413-1ht1xm88 362 8 to to IN cord-021413-1ht1xm88 362 9 reovirus reovirus NNP cord-021413-1ht1xm88 362 10 3 3 CD cord-021413-1ht1xm88 362 11 . . . cord-021413-1ht1xm88 363 1 A a DT cord-021413-1ht1xm88 363 2 s s NN cord-021413-1ht1xm88 363 3 reviewed review VBN cord-021413-1ht1xm88 363 4 by by IN cord-021413-1ht1xm88 363 5 Mcintosh Mcintosh NNP cord-021413-1ht1xm88 363 6 ( ( -LRB- cord-021413-1ht1xm88 363 7 1974 1974 CD cord-021413-1ht1xm88 363 8 ) ) -RRB- cord-021413-1ht1xm88 363 9 , , , cord-021413-1ht1xm88 363 10 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 363 11 are be VBP cord-021413-1ht1xm88 363 12 p p NN cord-021413-1ht1xm88 363 13 l l NN cord-021413-1ht1xm88 363 14 e e NN cord-021413-1ht1xm88 363 15 o o NN cord-021413-1ht1xm88 363 16 m m NN cord-021413-1ht1xm88 363 17 o o NN cord-021413-1ht1xm88 363 18 φ φ NN cord-021413-1ht1xm88 363 19 h h NN cord-021413-1ht1xm88 363 20 i i NN cord-021413-1ht1xm88 363 21 c c NNP cord-021413-1ht1xm88 363 22 , , , cord-021413-1ht1xm88 363 23 enveloped envelop VBN cord-021413-1ht1xm88 363 24 , , , cord-021413-1ht1xm88 363 25 and and CC cord-021413-1ht1xm88 363 26 variable variable JJ cord-021413-1ht1xm88 363 27 in in IN cord-021413-1ht1xm88 363 28 size size NN cord-021413-1ht1xm88 363 29 , , , cord-021413-1ht1xm88 363 30 measuring measure VBG cord-021413-1ht1xm88 363 31 about about IN cord-021413-1ht1xm88 363 32 8 8 CD cord-021413-1ht1xm88 363 33 0 0 CD cord-021413-1ht1xm88 363 34 -1 -1 NN cord-021413-1ht1xm88 363 35 5 5 CD cord-021413-1ht1xm88 363 36 0 0 CD cord-021413-1ht1xm88 363 37 n n NN cord-021413-1ht1xm88 363 38 m m NN cord-021413-1ht1xm88 363 39 in in IN cord-021413-1ht1xm88 363 40 diameter diameter NN cord-021413-1ht1xm88 363 41 . . . cord-021413-1ht1xm88 364 1 Peplomers peplomer NNS cord-021413-1ht1xm88 364 2 are be VBP cord-021413-1ht1xm88 364 3 1 1 CD cord-021413-1ht1xm88 364 4 2 2 CD cord-021413-1ht1xm88 364 5 -2 -2 SYM cord-021413-1ht1xm88 364 6 4 4 CD cord-021413-1ht1xm88 364 7 n n NN cord-021413-1ht1xm88 364 8 m m NN cord-021413-1ht1xm88 364 9 in in IN cord-021413-1ht1xm88 364 10 length length NN cord-021413-1ht1xm88 365 1 ( ( -LRB- cord-021413-1ht1xm88 365 2 Fig Fig NNP cord-021413-1ht1xm88 365 3 . . NNP cord-021413-1ht1xm88 365 4 4 4 CD cord-021413-1ht1xm88 365 5 ) ) -RRB- cord-021413-1ht1xm88 365 6 . . . cord-021413-1ht1xm88 366 1 Using use VBG cord-021413-1ht1xm88 366 2 various various JJ cord-021413-1ht1xm88 366 3 techniques technique NNS cord-021413-1ht1xm88 366 4 , , , cord-021413-1ht1xm88 366 5 a a DT cord-021413-1ht1xm88 366 6 n n NN cord-021413-1ht1xm88 366 7 u u NNP cord-021413-1ht1xm88 366 8 m m NN cord-021413-1ht1xm88 366 9 b b NN cord-021413-1ht1xm88 366 10 e e NN cord-021413-1ht1xm88 366 11 r r NN cord-021413-1ht1xm88 366 12 of of IN cord-021413-1ht1xm88 366 13 workers worker NNS cord-021413-1ht1xm88 366 14 have have VBP cord-021413-1ht1xm88 366 15 con con NN cord-021413-1ht1xm88 366 16 firmed firm VBN cord-021413-1ht1xm88 366 17 the the DT cord-021413-1ht1xm88 366 18 diameter diameter NN cord-021413-1ht1xm88 366 19 of of IN cord-021413-1ht1xm88 366 20 M M NNP cord-021413-1ht1xm88 366 21 H h NN cord-021413-1ht1xm88 366 22 V v NN cord-021413-1ht1xm88 366 23 virions virion NNS cord-021413-1ht1xm88 366 24 to to TO cord-021413-1ht1xm88 366 25 fall fall VB cord-021413-1ht1xm88 366 26 within within IN cord-021413-1ht1xm88 366 27 the the DT cord-021413-1ht1xm88 366 28 range range NN cord-021413-1ht1xm88 366 29 of of IN cord-021413-1ht1xm88 366 30 the the DT cord-021413-1ht1xm88 366 31 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 366 32 ( ( -LRB- cord-021413-1ht1xm88 366 33 Gledhill Gledhill NNP cord-021413-1ht1xm88 366 34 et et NNP cord-021413-1ht1xm88 366 35 al al NNP cord-021413-1ht1xm88 366 36 . . . cord-021413-1ht1xm88 367 1 , , , cord-021413-1ht1xm88 367 2 1955 1955 CD cord-021413-1ht1xm88 367 3 ; ; : cord-021413-1ht1xm88 367 4 Miyazaki Miyazaki NNP cord-021413-1ht1xm88 367 5 et et NNP cord-021413-1ht1xm88 367 6 al al NNP cord-021413-1ht1xm88 367 7 . . NNP cord-021413-1ht1xm88 367 8 , , , cord-021413-1ht1xm88 367 9 1957 1957 CD cord-021413-1ht1xm88 367 10 ; ; : cord-021413-1ht1xm88 367 11 Kraft Kraft NNP cord-021413-1ht1xm88 367 12 , , , cord-021413-1ht1xm88 367 13 1962a 1962a CD cord-021413-1ht1xm88 367 14 ; ; : cord-021413-1ht1xm88 367 15 Starr Starr NNP cord-021413-1ht1xm88 367 16 etal etal NNP cord-021413-1ht1xm88 367 17 . . NNP cord-021413-1ht1xm88 367 18 , , , cord-021413-1ht1xm88 367 19 1960 1960 CD cord-021413-1ht1xm88 367 20 ) ) -RRB- cord-021413-1ht1xm88 367 21 . . . cord-021413-1ht1xm88 368 1 Svoboda Svoboda NNP cord-021413-1ht1xm88 368 2 etal etal NNP cord-021413-1ht1xm88 368 3 . . . cord-021413-1ht1xm88 369 1 ( ( -LRB- cord-021413-1ht1xm88 369 2 1962 1962 CD cord-021413-1ht1xm88 369 3 ) ) -RRB- cord-021413-1ht1xm88 369 4 further further RB cord-021413-1ht1xm88 369 5 described describe VBD cord-021413-1ht1xm88 369 6 the the DT cord-021413-1ht1xm88 369 7 virion virion NN cord-021413-1ht1xm88 369 8 as as IN cord-021413-1ht1xm88 369 9 consisting consist VBG cord-021413-1ht1xm88 369 10 of of IN cord-021413-1ht1xm88 369 11 a a DT cord-021413-1ht1xm88 369 12 nucleoid nucleoid NNP cord-021413-1ht1xm88 369 13 sepa sepa NNP cord-021413-1ht1xm88 369 14 rated rate VBD cord-021413-1ht1xm88 369 15 from from IN cord-021413-1ht1xm88 369 16 an an DT cord-021413-1ht1xm88 369 17 outer outer JJ cord-021413-1ht1xm88 369 18 m m NN cord-021413-1ht1xm88 369 19 e e NN cord-021413-1ht1xm88 369 20 m m NN cord-021413-1ht1xm88 369 21 b b NN cord-021413-1ht1xm88 369 22 r r NN cord-021413-1ht1xm88 370 1 a a DT cord-021413-1ht1xm88 370 2 n n NN cord-021413-1ht1xm88 370 3 e e NN cord-021413-1ht1xm88 370 4 by by IN cord-021413-1ht1xm88 370 5 an an DT cord-021413-1ht1xm88 370 6 electron electron NN cord-021413-1ht1xm88 370 7 - - HYPH cord-021413-1ht1xm88 370 8 lucent lucent JJ cord-021413-1ht1xm88 370 9 space space NN cord-021413-1ht1xm88 370 10 . . . cord-021413-1ht1xm88 371 1 David David NNP cord-021413-1ht1xm88 371 2 - - HYPH cord-021413-1ht1xm88 371 3 Ferreira Ferreira NNP cord-021413-1ht1xm88 371 4 and and CC cord-021413-1ht1xm88 371 5 Manaker Manaker NNP cord-021413-1ht1xm88 371 6 ( ( -LRB- cord-021413-1ht1xm88 371 7 1965 1965 CD cord-021413-1ht1xm88 371 8 ) ) -RRB- cord-021413-1ht1xm88 371 9 , , , cord-021413-1ht1xm88 371 10 working work VBG cord-021413-1ht1xm88 371 11 with with IN cord-021413-1ht1xm88 371 12 M M NNP cord-021413-1ht1xm88 371 13 H h NN cord-021413-1ht1xm88 371 14 V v NN cord-021413-1ht1xm88 371 15 -A -A NNS cord-021413-1ht1xm88 371 16 5 5 CD cord-021413-1ht1xm88 371 17 9 9 CD cord-021413-1ht1xm88 371 18 in in IN cord-021413-1ht1xm88 371 19 tissue tissue NN cord-021413-1ht1xm88 371 20 culture culture NN cord-021413-1ht1xm88 371 21 , , , cord-021413-1ht1xm88 371 22 found find VBD cord-021413-1ht1xm88 371 23 that that IN cord-021413-1ht1xm88 371 24 the the DT cord-021413-1ht1xm88 371 25 virions virion NNS cord-021413-1ht1xm88 371 26 had have VBD cord-021413-1ht1xm88 371 27 a a DT cord-021413-1ht1xm88 371 28 m m NN cord-021413-1ht1xm88 371 29 e e NN cord-021413-1ht1xm88 371 30 a a NN cord-021413-1ht1xm88 371 31 n n NN cord-021413-1ht1xm88 371 32 diameter diameter NN cord-021413-1ht1xm88 371 33 of of IN cord-021413-1ht1xm88 371 34 75 75 CD cord-021413-1ht1xm88 371 35 nm nm NN cord-021413-1ht1xm88 371 36 with with IN cord-021413-1ht1xm88 371 37 an an DT cord-021413-1ht1xm88 371 38 electron electron NN cord-021413-1ht1xm88 371 39 - - HYPH cord-021413-1ht1xm88 371 40 dense dense JJ cord-021413-1ht1xm88 371 41 inner inner JJ cord-021413-1ht1xm88 371 42 shell shell NN cord-021413-1ht1xm88 371 43 , , , cord-021413-1ht1xm88 371 44 55 55 CD cord-021413-1ht1xm88 371 45 nm nm NN cord-021413-1ht1xm88 371 46 in in IN cord-021413-1ht1xm88 371 47 diameter diameter NN cord-021413-1ht1xm88 371 48 , , , cord-021413-1ht1xm88 371 49 separated separate VBN cord-021413-1ht1xm88 371 50 from from IN cord-021413-1ht1xm88 371 51 the the DT cord-021413-1ht1xm88 371 52 outer outer JJ cord-021413-1ht1xm88 371 53 double double NN cord-021413-1ht1xm88 371 54 m m NN cord-021413-1ht1xm88 371 55 e e NN cord-021413-1ht1xm88 371 56 m m NN cord-021413-1ht1xm88 371 57 b b NNP cord-021413-1ht1xm88 371 58 r r NNP cord-021413-1ht1xm88 371 59 a a NN cord-021413-1ht1xm88 371 60 n n NN cord-021413-1ht1xm88 371 61 e e NN cord-021413-1ht1xm88 371 62 by by IN cord-021413-1ht1xm88 371 63 an an DT cord-021413-1ht1xm88 371 64 electronlucent electronlucent JJ cord-021413-1ht1xm88 371 65 space space NN cord-021413-1ht1xm88 371 66 8 8 CD cord-021413-1ht1xm88 371 67 nm nm NN cord-021413-1ht1xm88 371 68 wide wide RB cord-021413-1ht1xm88 371 69 . . . cord-021413-1ht1xm88 372 1 Peplomers Peplomers NNP cord-021413-1ht1xm88 372 2 were be VBD cord-021413-1ht1xm88 372 3 1 1 CD cord-021413-1ht1xm88 372 4 6 6 CD cord-021413-1ht1xm88 372 5 . . . cord-021413-1ht1xm88 372 6 6 6 CD cord-021413-1ht1xm88 372 7 -2 -2 CD cord-021413-1ht1xm88 372 8 3 3 CD cord-021413-1ht1xm88 372 9 . . . cord-021413-1ht1xm88 373 1 4 4 LS cord-021413-1ht1xm88 373 2 n n NN cord-021413-1ht1xm88 373 3 m m NNP cord-021413-1ht1xm88 373 4 long long NN cord-021413-1ht1xm88 373 5 . . . cord-021413-1ht1xm88 374 1 Not not RB cord-021413-1ht1xm88 374 2 only only RB cord-021413-1ht1xm88 374 3 was be VBD cord-021413-1ht1xm88 374 4 the the DT cord-021413-1ht1xm88 374 5 virion virion NN cord-021413-1ht1xm88 374 6 significantly significantly RB cord-021413-1ht1xm88 374 7 smaller small JJR cord-021413-1ht1xm88 374 8 than than IN cord-021413-1ht1xm88 374 9 that that DT cord-021413-1ht1xm88 374 10 of of IN cord-021413-1ht1xm88 374 11 I -PRON- PRP cord-021413-1ht1xm88 374 12 B B NNP cord-021413-1ht1xm88 374 13 V v NN cord-021413-1ht1xm88 374 14 , , , cord-021413-1ht1xm88 374 15 but but CC cord-021413-1ht1xm88 374 16 the the DT cord-021413-1ht1xm88 374 17 peplomers peplomer NNS cord-021413-1ht1xm88 374 18 dif dif NNP cord-021413-1ht1xm88 374 19 fered fere VBN cord-021413-1ht1xm88 374 20 from from IN cord-021413-1ht1xm88 374 21 those those DT cord-021413-1ht1xm88 374 22 of of IN cord-021413-1ht1xm88 374 23 both both CC cord-021413-1ht1xm88 374 24 I -PRON- PRP cord-021413-1ht1xm88 374 25 B b NN cord-021413-1ht1xm88 374 26 V v NN cord-021413-1ht1xm88 374 27 and and CC cord-021413-1ht1xm88 374 28 H h NN cord-021413-1ht1xm88 374 29 C c NN cord-021413-1ht1xm88 374 30 V v NN cord-021413-1ht1xm88 374 31 2 2 CD cord-021413-1ht1xm88 374 32 2 2 CD cord-021413-1ht1xm88 374 33 9 9 CD cord-021413-1ht1xm88 374 34 E E NNS cord-021413-1ht1xm88 374 35 , , , cord-021413-1ht1xm88 374 36 being be VBG cord-021413-1ht1xm88 374 37 conerather conerather NN cord-021413-1ht1xm88 374 38 than than IN cord-021413-1ht1xm88 374 39 club club NN cord-021413-1ht1xm88 374 40 - - HYPH cord-021413-1ht1xm88 374 41 shaped shape VBN cord-021413-1ht1xm88 374 42 . . . cord-021413-1ht1xm88 375 1 Mallucci Mallucci NNP cord-021413-1ht1xm88 375 2 ( ( -LRB- cord-021413-1ht1xm88 375 3 1965 1965 CD cord-021413-1ht1xm88 375 4 ) ) -RRB- cord-021413-1ht1xm88 375 5 _SP cord-021413-1ht1xm88 376 1 In in IN cord-021413-1ht1xm88 376 2 general general JJ cord-021413-1ht1xm88 376 3 , , , cord-021413-1ht1xm88 376 4 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 376 5 are be VBP cord-021413-1ht1xm88 376 6 inacti inacti JJ cord-021413-1ht1xm88 376 7 vated vate VBN cord-021413-1ht1xm88 376 8 at at IN cord-021413-1ht1xm88 376 9 56 56 CD cord-021413-1ht1xm88 376 10 ° ° NN cord-021413-1ht1xm88 376 11 C c NN cord-021413-1ht1xm88 376 12 in in IN cord-021413-1ht1xm88 376 13 10 10 CD cord-021413-1ht1xm88 376 14 - - SYM cord-021413-1ht1xm88 376 15 15 15 CD cord-021413-1ht1xm88 376 16 min min NN cord-021413-1ht1xm88 376 17 , , , cord-021413-1ht1xm88 376 18 at at IN cord-021413-1ht1xm88 376 19 37 37 CD cord-021413-1ht1xm88 376 20 ° ° NN cord-021413-1ht1xm88 376 21 C c NN cord-021413-1ht1xm88 376 22 in in IN cord-021413-1ht1xm88 376 23 several several JJ cord-021413-1ht1xm88 376 24 days day NNS cord-021413-1ht1xm88 376 25 , , , cord-021413-1ht1xm88 376 26 and and CC cord-021413-1ht1xm88 376 27 at at IN cord-021413-1ht1xm88 376 28 4 4 CD cord-021413-1ht1xm88 376 29 ° ° NN cord-021413-1ht1xm88 376 30 C c NN cord-021413-1ht1xm88 376 31 in in IN cord-021413-1ht1xm88 376 32 several several JJ cord-021413-1ht1xm88 376 33 months month NNS cord-021413-1ht1xm88 376 34 ( ( -LRB- cord-021413-1ht1xm88 376 35 Tyrell Tyrell NNP cord-021413-1ht1xm88 376 36 etal etal NNP cord-021413-1ht1xm88 376 37 . . . cord-021413-1ht1xm88 377 1 , , , cord-021413-1ht1xm88 377 2 1968 1968 CD cord-021413-1ht1xm88 377 3 ; ; : cord-021413-1ht1xm88 377 4 Kapikian Kapikian NNP cord-021413-1ht1xm88 377 5 , , , cord-021413-1ht1xm88 377 6 1975 1975 CD cord-021413-1ht1xm88 377 7 ) ) -RRB- cord-021413-1ht1xm88 377 8 . . . cord-021413-1ht1xm88 378 1 Wildtype Wildtype NNP cord-021413-1ht1xm88 378 2 MHV MHV NNP cord-021413-1ht1xm88 378 3 isolates isolate NNS cord-021413-1ht1xm88 378 4 also also RB cord-021413-1ht1xm88 378 5 fall fall VBP cord-021413-1ht1xm88 378 6 into into IN cord-021413-1ht1xm88 378 7 this this DT cord-021413-1ht1xm88 378 8 range range NN cord-021413-1ht1xm88 378 9 of of IN cord-021413-1ht1xm88 378 10 sensitivity sensitivity NN cord-021413-1ht1xm88 378 11 Gledhill Gledhill NNP cord-021413-1ht1xm88 378 12 and and CC cord-021413-1ht1xm88 378 13 Andrewes Andrewes NNP cord-021413-1ht1xm88 378 14 , , , cord-021413-1ht1xm88 378 15 1951 1951 CD cord-021413-1ht1xm88 378 16 ; ; : cord-021413-1ht1xm88 378 17 Gledhill Gledhill NNP cord-021413-1ht1xm88 378 18 et et NNP cord-021413-1ht1xm88 378 19 al al NNP cord-021413-1ht1xm88 378 20 . . NNP cord-021413-1ht1xm88 378 21 , , , cord-021413-1ht1xm88 378 22 1955 1955 CD cord-021413-1ht1xm88 378 23 ; ; : cord-021413-1ht1xm88 378 24 Kraft Kraft NNP cord-021413-1ht1xm88 378 25 , , , cord-021413-1ht1xm88 378 26 1962a 1962a CD cord-021413-1ht1xm88 378 27 ) ) -RRB- cord-021413-1ht1xm88 378 28 . . . cord-021413-1ht1xm88 379 1 Hirano Hirano NNP cord-021413-1ht1xm88 379 2 et et NNP cord-021413-1ht1xm88 379 3 al al NNP cord-021413-1ht1xm88 379 4 . . . cord-021413-1ht1xm88 380 1 ( ( -LRB- cord-021413-1ht1xm88 380 2 1978 1978 CD cord-021413-1ht1xm88 380 3 ) ) -RRB- cord-021413-1ht1xm88 380 4 , , , cord-021413-1ht1xm88 380 5 however however RB cord-021413-1ht1xm88 380 6 , , , cord-021413-1ht1xm88 380 7 indicated indicate VBD cord-021413-1ht1xm88 380 8 that that IN cord-021413-1ht1xm88 380 9 MHV2 MHV2 NNP cord-021413-1ht1xm88 380 10 is be VBZ cord-021413-1ht1xm88 380 11 not not RB cord-021413-1ht1xm88 380 12 completely completely RB cord-021413-1ht1xm88 380 13 destroyed destroy VBN cord-021413-1ht1xm88 380 14 at at IN cord-021413-1ht1xm88 380 15 56 56 CD cord-021413-1ht1xm88 380 16 ° ° NN cord-021413-1ht1xm88 380 17 C c NN cord-021413-1ht1xm88 380 18 for for IN cord-021413-1ht1xm88 380 19 30 30 CD cord-021413-1ht1xm88 380 20 min min NN cord-021413-1ht1xm88 380 21 and and CC cord-021413-1ht1xm88 380 22 is be VBZ cord-021413-1ht1xm88 380 23 stable stable JJ cord-021413-1ht1xm88 380 24 at at IN cord-021413-1ht1xm88 380 25 50 50 CD cord-021413-1ht1xm88 380 26 T t NN cord-021413-1ht1xm88 380 27 for for IN cord-021413-1ht1xm88 380 28 15 15 CD cord-021413-1ht1xm88 380 29 min min NN cord-021413-1ht1xm88 380 30 in in IN cord-021413-1ht1xm88 380 31 1 1 CD cord-021413-1ht1xm88 380 32 Μ Μ NNP cord-021413-1ht1xm88 380 33 MgClg MgClg NNP cord-021413-1ht1xm88 380 34 or or CC cord-021413-1ht1xm88 380 35 MgS04 MgS04 NNP cord-021413-1ht1xm88 380 36 but but CC cord-021413-1ht1xm88 380 37 not not RB cord-021413-1ht1xm88 380 38 in in IN cord-021413-1ht1xm88 380 39 water water NN cord-021413-1ht1xm88 380 40 . . . cord-021413-1ht1xm88 381 1 Freezing freeze VBG cord-021413-1ht1xm88 381 2 and and CC cord-021413-1ht1xm88 381 3 thawing thawing NN cord-021413-1ht1xm88 381 4 or or CC cord-021413-1ht1xm88 381 5 sonication sonication NN cord-021413-1ht1xm88 381 6 at at IN cord-021413-1ht1xm88 381 7 20 20 CD cord-021413-1ht1xm88 381 8 kc kc NNP cord-021413-1ht1xm88 381 9 for for IN cord-021413-1ht1xm88 381 10 3 3 CD cord-021413-1ht1xm88 381 11 min min NN cord-021413-1ht1xm88 381 12 does do VBZ cord-021413-1ht1xm88 381 13 not not RB cord-021413-1ht1xm88 381 14 affect affect VB cord-021413-1ht1xm88 381 15 the the DT cord-021413-1ht1xm88 381 16 virus virus NN cord-021413-1ht1xm88 381 17 titer titer NN cord-021413-1ht1xm88 381 18 . . . cord-021413-1ht1xm88 382 1 c. c. NNP cord-021413-1ht1xm88 382 2 Effect Effect NNP cord-021413-1ht1xm88 382 3 of of IN cord-021413-1ht1xm88 382 4 Chemicals Chemicals NNPS cord-021413-1ht1xm88 382 5 . . . cord-021413-1ht1xm88 383 1 All all DT cord-021413-1ht1xm88 383 2 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 383 3 are be VBP cord-021413-1ht1xm88 383 4 sensitive sensitive JJ cord-021413-1ht1xm88 383 5 to to IN cord-021413-1ht1xm88 383 6 ether ether NN cord-021413-1ht1xm88 383 7 when when WRB cord-021413-1ht1xm88 383 8 exposed expose VBN cord-021413-1ht1xm88 383 9 overnight overnight RB cord-021413-1ht1xm88 383 10 at at IN cord-021413-1ht1xm88 383 11 2 2 CD cord-021413-1ht1xm88 383 12 ° ° NN cord-021413-1ht1xm88 383 13 -4 -4 NN cord-021413-1ht1xm88 383 14 ° ° NN cord-021413-1ht1xm88 383 15 C C NNP cord-021413-1ht1xm88 383 16 . . . cord-021413-1ht1xm88 384 1 Chloroform chloroform NN cord-021413-1ht1xm88 384 2 also also RB cord-021413-1ht1xm88 384 3 de de VBP cord-021413-1ht1xm88 384 4 stroys stroys NNP cord-021413-1ht1xm88 384 5 or or CC cord-021413-1ht1xm88 384 6 reduces reduce VBZ cord-021413-1ht1xm88 384 7 infectivity infectivity NN cord-021413-1ht1xm88 384 8 ( ( -LRB- cord-021413-1ht1xm88 384 9 Mcintosh Mcintosh NNP cord-021413-1ht1xm88 384 10 , , , cord-021413-1ht1xm88 384 11 1974 1974 CD cord-021413-1ht1xm88 384 12 ) ) -RRB- cord-021413-1ht1xm88 384 13 . . . cord-021413-1ht1xm88 385 1 Fifty fifty CD cord-021413-1ht1xm88 385 2 percent percent NN cord-021413-1ht1xm88 385 3 glycerol glycerol NN cord-021413-1ht1xm88 385 4 inactivates inactivate VBZ cord-021413-1ht1xm88 385 5 MHVl MHVl NNS cord-021413-1ht1xm88 385 6 after after IN cord-021413-1ht1xm88 385 7 6 6 CD cord-021413-1ht1xm88 385 8 weeks week NNS cord-021413-1ht1xm88 385 9 at at IN cord-021413-1ht1xm88 385 10 2 2 CD cord-021413-1ht1xm88 385 11 ° ° NN cord-021413-1ht1xm88 385 12 C c NN cord-021413-1ht1xm88 385 13 ( ( -LRB- cord-021413-1ht1xm88 385 14 Gledhill Gledhill NNP cord-021413-1ht1xm88 385 15 and and CC cord-021413-1ht1xm88 385 16 Andrewes Andrewes NNP cord-021413-1ht1xm88 385 17 ( ( -LRB- cord-021413-1ht1xm88 385 18 1951 1951 CD cord-021413-1ht1xm88 385 19 ) ) -RRB- cord-021413-1ht1xm88 385 20 . . . cord-021413-1ht1xm88 386 1 Sodium sodium NN cord-021413-1ht1xm88 386 2 deoxycholate deoxycholate NN cord-021413-1ht1xm88 386 3 reduces reduce VBZ cord-021413-1ht1xm88 386 4 the the DT cord-021413-1ht1xm88 386 5 titer titer NN cord-021413-1ht1xm88 386 6 of of IN cord-021413-1ht1xm88 386 7 LIVIM LIVIM NNP cord-021413-1ht1xm88 386 8 significantly significantly RB cord-021413-1ht1xm88 386 9 ( ( -LRB- cord-021413-1ht1xm88 386 10 Kraft Kraft NNP cord-021413-1ht1xm88 386 11 , , , cord-021413-1ht1xm88 386 12 1962a 1962a CD cord-021413-1ht1xm88 386 13 ) ) -RRB- cord-021413-1ht1xm88 386 14 , , , cord-021413-1ht1xm88 386 15 but but CC cord-021413-1ht1xm88 386 16 Calisher Calisher NNP cord-021413-1ht1xm88 386 17 and and CC cord-021413-1ht1xm88 386 18 Rowe Rowe NNP cord-021413-1ht1xm88 386 19 ( ( -LRB- cord-021413-1ht1xm88 386 20 1966 1966 CD cord-021413-1ht1xm88 386 21 ) ) -RRB- cord-021413-1ht1xm88 386 22 regard regard NN cord-021413-1ht1xm88 386 23 MHV MHV NNP cord-021413-1ht1xm88 386 24 virus virus NN cord-021413-1ht1xm88 386 25 as as IN cord-021413-1ht1xm88 386 26 moderately moderately RB cord-021413-1ht1xm88 386 27 resistant resistant JJ cord-021413-1ht1xm88 386 28 . . . cord-021413-1ht1xm88 387 1 According accord VBG cord-021413-1ht1xm88 387 2 to to IN cord-021413-1ht1xm88 387 3 Hirano Hirano NNP cord-021413-1ht1xm88 387 4 et et FW cord-021413-1ht1xm88 387 5 al al NNP cord-021413-1ht1xm88 387 6 . . . cord-021413-1ht1xm88 388 1 ( ( -LRB- cord-021413-1ht1xm88 388 2 1978 1978 CD cord-021413-1ht1xm88 388 3 ) ) -RRB- cord-021413-1ht1xm88 388 4 , , , cord-021413-1ht1xm88 388 5 MHV2 MHV2 NNP cord-021413-1ht1xm88 388 6 is be VBZ cord-021413-1ht1xm88 388 7 completely completely RB cord-021413-1ht1xm88 388 8 inactivated inactivate VBN cord-021413-1ht1xm88 388 9 by by IN cord-021413-1ht1xm88 388 10 ether ether NN cord-021413-1ht1xm88 388 11 , , , cord-021413-1ht1xm88 388 12 chloroform chloroform NN cord-021413-1ht1xm88 388 13 , , , cord-021413-1ht1xm88 388 14 sodium sodium NN cord-021413-1ht1xm88 388 15 deoxycholate deoxycholate NN cord-021413-1ht1xm88 388 16 , , , cord-021413-1ht1xm88 388 17 and and CC cord-021413-1ht1xm88 388 18 /3-propiolactone /3-propiolactone CD cord-021413-1ht1xm88 388 19 , , , cord-021413-1ht1xm88 388 20 but but CC cord-021413-1ht1xm88 388 21 it -PRON- PRP cord-021413-1ht1xm88 388 22 is be VBZ cord-021413-1ht1xm88 388 23 completely completely RB cord-021413-1ht1xm88 388 24 resistant resistant JJ cord-021413-1ht1xm88 388 25 to to IN cord-021413-1ht1xm88 388 26 trypsin trypsin NN cord-021413-1ht1xm88 388 27 . . . cord-021413-1ht1xm88 389 1 Mutagenesis Mutagenesis NNP cord-021413-1ht1xm88 389 2 has have VBZ cord-021413-1ht1xm88 389 3 been be VBN cord-021413-1ht1xm88 389 4 reported report VBN cord-021413-1ht1xm88 389 5 by by IN cord-021413-1ht1xm88 389 6 means mean NNS cord-021413-1ht1xm88 389 7 of of IN cord-021413-1ht1xm88 389 8 Nmethyl-/V'-nitroguanidine Nmethyl-/V'-nitroguanidine NNP cord-021413-1ht1xm88 389 9 or or CC cord-021413-1ht1xm88 389 10 5-fluorouridine 5-fluorouridine CD cord-021413-1ht1xm88 389 11 and and CC cord-021413-1ht1xm88 389 12 by by IN cord-021413-1ht1xm88 389 13 5-azacytidine 5-azacytidine CD cord-021413-1ht1xm88 389 14 or or CC cord-021413-1ht1xm88 389 15 5-fluorouracil 5-fluorouracil CD cord-021413-1ht1xm88 389 16 ( ( -LRB- cord-021413-1ht1xm88 389 17 Haspel Haspel NNP cord-021413-1ht1xm88 389 18 et et NNP cord-021413-1ht1xm88 389 19 al al NNP cord-021413-1ht1xm88 389 20 . . NNP cord-021413-1ht1xm88 389 21 , , , cord-021413-1ht1xm88 389 22 1978 1978 CD cord-021413-1ht1xm88 389 23 ) ) -RRB- cord-021413-1ht1xm88 389 24 . . . cord-021413-1ht1xm88 390 1 The the DT cord-021413-1ht1xm88 390 2 pH pH NNP cord-021413-1ht1xm88 390 3 stability stability NN cord-021413-1ht1xm88 390 4 of of IN cord-021413-1ht1xm88 390 5 all all DT cord-021413-1ht1xm88 390 6 known know VBN cord-021413-1ht1xm88 390 7 murine murine JJ cord-021413-1ht1xm88 390 8 hepatitis hepatitis NN cord-021413-1ht1xm88 390 9 viruses virus NNS cord-021413-1ht1xm88 390 10 has have VBZ cord-021413-1ht1xm88 390 11 not not RB cord-021413-1ht1xm88 390 12 been be VBN cord-021413-1ht1xm88 390 13 reported report VBN cord-021413-1ht1xm88 390 14 . . . cord-021413-1ht1xm88 391 1 For for IN cord-021413-1ht1xm88 391 2 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 391 3 in in IN cord-021413-1ht1xm88 391 4 general general JJ cord-021413-1ht1xm88 391 5 , , , cord-021413-1ht1xm88 391 6 acid acid JJ cord-021413-1ht1xm88 391 7 sensitivity sensitivity NN cord-021413-1ht1xm88 391 8 is be VBZ cord-021413-1ht1xm88 391 9 regarded regard VBN cord-021413-1ht1xm88 391 10 as as IN cord-021413-1ht1xm88 391 11 variable variable JJ cord-021413-1ht1xm88 391 12 ( ( -LRB- cord-021413-1ht1xm88 391 13 Mcintosh Mcintosh NNP cord-021413-1ht1xm88 391 14 , , , cord-021413-1ht1xm88 391 15 1974 1974 CD cord-021413-1ht1xm88 391 16 ) ) -RRB- cord-021413-1ht1xm88 391 17 . . . cord-021413-1ht1xm88 392 1 Hirano Hirano NNP cord-021413-1ht1xm88 392 2 et et NNP cord-021413-1ht1xm88 392 3 al al NNP cord-021413-1ht1xm88 392 4 . . . cord-021413-1ht1xm88 393 1 ( ( -LRB- cord-021413-1ht1xm88 393 2 1978 1978 CD cord-021413-1ht1xm88 393 3 ) ) -RRB- cord-021413-1ht1xm88 393 4 found find VBD cord-021413-1ht1xm88 393 5 that that IN cord-021413-1ht1xm88 393 6 MHV2 MHV2 NNP cord-021413-1ht1xm88 393 7 is be VBZ cord-021413-1ht1xm88 393 8 stable stable JJ cord-021413-1ht1xm88 393 9 be be VB cord-021413-1ht1xm88 393 10 tween tween NN cord-021413-1ht1xm88 393 11 pH ph NN cord-021413-1ht1xm88 393 12 3 3 CD cord-021413-1ht1xm88 393 13 and and CC cord-021413-1ht1xm88 393 14 9 9 CD cord-021413-1ht1xm88 393 15 at at IN cord-021413-1ht1xm88 393 16 37 37 CD cord-021413-1ht1xm88 393 17 ° ° NN cord-021413-1ht1xm88 393 18 C c NN cord-021413-1ht1xm88 393 19 for for IN cord-021413-1ht1xm88 393 20 30 30 CD cord-021413-1ht1xm88 393 21 min min NN cord-021413-1ht1xm88 393 22 . . . cord-021413-1ht1xm88 394 1 Calisher Calisher NNP cord-021413-1ht1xm88 394 2 and and CC cord-021413-1ht1xm88 394 3 Rowe Rowe NNP cord-021413-1ht1xm88 394 4 ( ( -LRB- cord-021413-1ht1xm88 394 5 1966 1966 CD cord-021413-1ht1xm88 394 6 ) ) -RRB- cord-021413-1ht1xm88 395 1 Although although IN cord-021413-1ht1xm88 395 2 they -PRON- PRP cord-021413-1ht1xm88 395 3 have have VBP cord-021413-1ht1xm88 395 4 been be VBN cord-021413-1ht1xm88 395 5 sought seek VBN cord-021413-1ht1xm88 395 6 , , , cord-021413-1ht1xm88 395 7 hemagglutinins hemagglutinin NNS cord-021413-1ht1xm88 395 8 have have VBP cord-021413-1ht1xm88 395 9 not not RB cord-021413-1ht1xm88 395 10 been be VBN cord-021413-1ht1xm88 395 11 demonstrated demonstrate VBN cord-021413-1ht1xm88 395 12 for for IN cord-021413-1ht1xm88 395 13 MHV MHV NNP cord-021413-1ht1xm88 395 14 strains strain NNS cord-021413-1ht1xm88 395 15 ( ( -LRB- cord-021413-1ht1xm88 395 16 see see VB cord-021413-1ht1xm88 395 17 , , , cord-021413-1ht1xm88 395 18 e.g. e.g. RB cord-021413-1ht1xm88 395 19 , , , cord-021413-1ht1xm88 395 20 Hirano Hirano NNP cord-021413-1ht1xm88 395 21 et et NNP cord-021413-1ht1xm88 395 22 al al NNP cord-021413-1ht1xm88 395 23 . . . cord-021413-1ht1xm88 396 1 , , , cord-021413-1ht1xm88 396 2 1978 1978 CD cord-021413-1ht1xm88 396 3 ; ; : cord-021413-1ht1xm88 396 4 Kraft Kraft NNP cord-021413-1ht1xm88 396 5 , , , cord-021413-1ht1xm88 396 6 1962a 1962a CD cord-021413-1ht1xm88 396 7 ; ; : cord-021413-1ht1xm88 396 8 Bradbume Bradbume NNP cord-021413-1ht1xm88 396 9 , , , cord-021413-1ht1xm88 396 10 1970 1970 CD cord-021413-1ht1xm88 396 11 ; ; : cord-021413-1ht1xm88 396 12 Miyazaki Miyazaki NNP cord-021413-1ht1xm88 396 13 etal etal NNP cord-021413-1ht1xm88 396 14 . . NNP cord-021413-1ht1xm88 396 15 , , , cord-021413-1ht1xm88 396 16 1957 1957 CD cord-021413-1ht1xm88 396 17 ) ) -RRB- cord-021413-1ht1xm88 396 18 , , , cord-021413-1ht1xm88 396 19 but but CC cord-021413-1ht1xm88 396 20 two two CD cord-021413-1ht1xm88 396 21 human human JJ cord-021413-1ht1xm88 396 22 Coronavirus Coronavirus NNP cord-021413-1ht1xm88 396 23 strains strain NNS cord-021413-1ht1xm88 396 24 do do VBP cord-021413-1ht1xm88 396 25 agglutinate agglutinate VB cord-021413-1ht1xm88 396 26 human human JJ cord-021413-1ht1xm88 396 27 0 0 CD cord-021413-1ht1xm88 396 28 erythrocytes erythrocyte NNS cord-021413-1ht1xm88 396 29 ( ( -LRB- cord-021413-1ht1xm88 396 30 Kaye Kaye NNP cord-021413-1ht1xm88 396 31 and and CC cord-021413-1ht1xm88 396 32 Dowdle Dowdle NNP cord-021413-1ht1xm88 396 33 , , , cord-021413-1ht1xm88 396 34 1969 1969 CD cord-021413-1ht1xm88 396 35 _SP cord-021413-1ht1xm88 396 36 Cheever Cheever NNP cord-021413-1ht1xm88 396 37 et et NNP cord-021413-1ht1xm88 396 38 al al NNP cord-021413-1ht1xm88 396 39 . . . cord-021413-1ht1xm88 397 1 ( ( -LRB- cord-021413-1ht1xm88 397 2 1949 1949 CD cord-021413-1ht1xm88 397 3 ) ) -RRB- cord-021413-1ht1xm88 397 4 found find VBD cord-021413-1ht1xm88 397 5 JHM JHM NNP cord-021413-1ht1xm88 397 6 virus virus NN cord-021413-1ht1xm88 397 7 to to TO cord-021413-1ht1xm88 397 8 be be VB cord-021413-1ht1xm88 397 9 unrelated unrelated JJ cord-021413-1ht1xm88 397 10 to to IN cord-021413-1ht1xm88 397 11 other other JJ cord-021413-1ht1xm88 397 12 neurotropic neurotropic NNS cord-021413-1ht1xm88 397 13 viruses virus NNS cord-021413-1ht1xm88 397 14 , , , cord-021413-1ht1xm88 397 15 including include VBG cord-021413-1ht1xm88 397 16 GD GD NNP cord-021413-1ht1xm88 397 17 VII VII NNP cord-021413-1ht1xm88 397 18 , , , cord-021413-1ht1xm88 397 19 Pseudorabies Pseudorabies NNP cord-021413-1ht1xm88 397 20 , , , cord-021413-1ht1xm88 397 21 Lansing Lansing NNP cord-021413-1ht1xm88 397 22 poliomyelitis poliomyelitis NN cord-021413-1ht1xm88 397 23 , , , cord-021413-1ht1xm88 397 24 and and CC cord-021413-1ht1xm88 397 25 Mengo Mengo NNP cord-021413-1ht1xm88 397 26 virus virus NN cord-021413-1ht1xm88 397 27 . . . cord-021413-1ht1xm88 398 1 Kraft Kraft NNP cord-021413-1ht1xm88 398 2 ( ( -LRB- cord-021413-1ht1xm88 398 3 1962b 1962b CD cord-021413-1ht1xm88 398 4 ) ) -RRB- cord-021413-1ht1xm88 398 5 found find VBD cord-021413-1ht1xm88 398 6 no no DT cord-021413-1ht1xm88 398 7 relationship relationship NN cord-021413-1ht1xm88 398 8 between between IN cord-021413-1ht1xm88 398 9 LIVIM LIVIM NNP cord-021413-1ht1xm88 398 10 , , , cord-021413-1ht1xm88 398 11 EDIM EDIM NNP cord-021413-1ht1xm88 398 12 , , , cord-021413-1ht1xm88 398 13 and and CC cord-021413-1ht1xm88 398 14 reovirus reovirus NNP cord-021413-1ht1xm88 398 15 3 3 CD cord-021413-1ht1xm88 398 16 . . . cord-021413-1ht1xm88 399 1 With with IN cord-021413-1ht1xm88 399 2 regard regard NN cord-021413-1ht1xm88 399 3 to to IN cord-021413-1ht1xm88 399 4 other other JJ cord-021413-1ht1xm88 399 5 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 399 6 , , , cord-021413-1ht1xm88 399 7 the the DT cord-021413-1ht1xm88 399 8 picture picture NN cord-021413-1ht1xm88 399 9 is be VBZ cord-021413-1ht1xm88 399 10 somewhat somewhat RB cord-021413-1ht1xm88 399 11 different different JJ cord-021413-1ht1xm88 399 12 , , , cord-021413-1ht1xm88 399 13 for for IN cord-021413-1ht1xm88 399 14 as as IN cord-021413-1ht1xm88 399 15 a a DT cord-021413-1ht1xm88 399 16 group group NN cord-021413-1ht1xm88 399 17 , , , cord-021413-1ht1xm88 399 18 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 399 19 display display VBP cord-021413-1ht1xm88 399 20 complex complex JJ cord-021413-1ht1xm88 399 21 serologic serologic NN cord-021413-1ht1xm88 399 22 variability variability NN cord-021413-1ht1xm88 399 23 ( ( -LRB- cord-021413-1ht1xm88 399 24 Bradburne Bradburne NNP cord-021413-1ht1xm88 399 25 , , , cord-021413-1ht1xm88 399 26 1970 1970 CD cord-021413-1ht1xm88 399 27 ; ; . cord-021413-1ht1xm88 400 1 Mcintosh Mcintosh NNP cord-021413-1ht1xm88 400 2 et et NNP cord-021413-1ht1xm88 400 3 al al NNP cord-021413-1ht1xm88 400 4 . . NNP cord-021413-1ht1xm88 400 5 , , , cord-021413-1ht1xm88 400 6 1969 1969 CD cord-021413-1ht1xm88 400 7 ) ) -RRB- cord-021413-1ht1xm88 400 8 . . . cord-021413-1ht1xm88 401 1 MHV MHV NNP cord-021413-1ht1xm88 401 2 is be VBZ cord-021413-1ht1xm88 401 3 serologically serologically RB cord-021413-1ht1xm88 401 4 closely closely RB cord-021413-1ht1xm88 401 5 related relate VBN cord-021413-1ht1xm88 401 6 to to IN cord-021413-1ht1xm88 401 7 RCV RCV NNP cord-021413-1ht1xm88 401 8 and and CC cord-021413-1ht1xm88 401 9 SDAV SDAV NNP cord-021413-1ht1xm88 401 10 in in IN cord-021413-1ht1xm88 401 11 complement complement JJ cord-021413-1ht1xm88 401 12 fixation fixation NN cord-021413-1ht1xm88 401 13 tests test NNS cord-021413-1ht1xm88 401 14 and and CC cord-021413-1ht1xm88 401 15 distantly distantly RB cord-021413-1ht1xm88 401 16 related related JJ cord-021413-1ht1xm88 401 17 to to IN cord-021413-1ht1xm88 401 18 RCV RCV NNP cord-021413-1ht1xm88 401 19 in in IN cord-021413-1ht1xm88 401 20 cross cross JJ cord-021413-1ht1xm88 401 21 - - JJ cord-021413-1ht1xm88 401 22 neutralization neutralization JJ cord-021413-1ht1xm88 401 23 tests test NNS cord-021413-1ht1xm88 402 1 ( ( -LRB- cord-021413-1ht1xm88 402 2 Parker Parker NNP cord-021413-1ht1xm88 402 3 et et NNP cord-021413-1ht1xm88 402 4 al al NNP cord-021413-1ht1xm88 402 5 . . NNP cord-021413-1ht1xm88 402 6 , , , cord-021413-1ht1xm88 402 7 1970 1970 CD cord-021413-1ht1xm88 402 8 ; ; . cord-021413-1ht1xm88 403 1 Bhatt Bhatt NNP cord-021413-1ht1xm88 403 2 et et NNP cord-021413-1ht1xm88 403 3 al al NNP cord-021413-1ht1xm88 403 4 . . NNP cord-021413-1ht1xm88 403 5 , , , cord-021413-1ht1xm88 403 6 1972 1972 CD cord-021413-1ht1xm88 403 7 ) ) -RRB- cord-021413-1ht1xm88 403 8 . . . cord-021413-1ht1xm88 404 1 Several several JJ cord-021413-1ht1xm88 404 2 strains strain NNS cord-021413-1ht1xm88 404 3 of of IN cord-021413-1ht1xm88 404 4 MHV MHV NNP cord-021413-1ht1xm88 404 5 are be VBP cord-021413-1ht1xm88 404 6 closely closely RB cord-021413-1ht1xm88 404 7 related relate VBN cord-021413-1ht1xm88 404 8 to to IN cord-021413-1ht1xm88 404 9 human human JJ cord-021413-1ht1xm88 404 10 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 404 11 OC OC NNP cord-021413-1ht1xm88 404 12 38 38 CD cord-021413-1ht1xm88 404 13 and and CC cord-021413-1ht1xm88 404 14 OC OC NNP cord-021413-1ht1xm88 404 15 43 43 CD cord-021413-1ht1xm88 404 16 , , , cord-021413-1ht1xm88 404 17 and and CC cord-021413-1ht1xm88 404 18 MHV3 MHV3 NNP cord-021413-1ht1xm88 404 19 is be VBZ cord-021413-1ht1xm88 404 20 related relate VBN cord-021413-1ht1xm88 404 21 to to IN cord-021413-1ht1xm88 404 22 HCV-229E HCV-229E NNP cord-021413-1ht1xm88 404 23 ( ( -LRB- cord-021413-1ht1xm88 404 24 Bradbume Bradbume NNP cord-021413-1ht1xm88 404 25 , , , cord-021413-1ht1xm88 404 26 1970 1970 CD cord-021413-1ht1xm88 404 27 ) ) -RRB- cord-021413-1ht1xm88 404 28 . . . cord-021413-1ht1xm88 405 1 Antibody antibody NN cord-021413-1ht1xm88 405 2 to to IN cord-021413-1ht1xm88 405 3 MHV MHV NNP cord-021413-1ht1xm88 405 4 strains strain NNS cord-021413-1ht1xm88 405 5 commonly commonly RB cord-021413-1ht1xm88 405 6 found find VBN cord-021413-1ht1xm88 405 7 in in IN cord-021413-1ht1xm88 405 8 human human JJ cord-021413-1ht1xm88 405 9 sera sera NNP cord-021413-1ht1xm88 405 10 is be VBZ cord-021413-1ht1xm88 405 11 probably probably RB cord-021413-1ht1xm88 405 12 present present JJ cord-021413-1ht1xm88 405 13 because because IN cord-021413-1ht1xm88 405 14 of of IN cord-021413-1ht1xm88 405 15 endemic endemic JJ cord-021413-1ht1xm88 405 16 human human JJ cord-021413-1ht1xm88 405 17 infection infection NN cord-021413-1ht1xm88 405 18 with with IN cord-021413-1ht1xm88 405 19 related related JJ cord-021413-1ht1xm88 405 20 coronavimses coronavimse NNS cord-021413-1ht1xm88 405 21 ( ( -LRB- cord-021413-1ht1xm88 405 22 Hartley Hartley NNP cord-021413-1ht1xm88 405 23 et et NNP cord-021413-1ht1xm88 405 24 al al NNP cord-021413-1ht1xm88 405 25 . . NNP cord-021413-1ht1xm88 405 26 , , , cord-021413-1ht1xm88 405 27 1964 1964 CD cord-021413-1ht1xm88 405 28 ) ) -RRB- cord-021413-1ht1xm88 405 29 . . . cord-021413-1ht1xm88 406 1 Electron electron NN cord-021413-1ht1xm88 406 2 micrographs micrograph NNS cord-021413-1ht1xm88 406 3 and and CC cord-021413-1ht1xm88 406 4 studies study NNS cord-021413-1ht1xm88 406 5 using use VBG cord-021413-1ht1xm88 406 6 fluorochrome fluorochrome NN cord-021413-1ht1xm88 406 7 stains stain NNS cord-021413-1ht1xm88 406 8 indicate indicate VBP cord-021413-1ht1xm88 406 9 that that IN cord-021413-1ht1xm88 406 10 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 406 11 develop develop VB cord-021413-1ht1xm88 406 12 exclusively exclusively RB cord-021413-1ht1xm88 406 13 in in IN cord-021413-1ht1xm88 406 14 the the DT cord-021413-1ht1xm88 406 15 cyto cyto NN cord-021413-1ht1xm88 406 16 plasm plasm NN cord-021413-1ht1xm88 406 17 of of IN cord-021413-1ht1xm88 406 18 infected infected JJ cord-021413-1ht1xm88 406 19 cells cell NNS cord-021413-1ht1xm88 406 20 , , , cord-021413-1ht1xm88 406 21 that that IN cord-021413-1ht1xm88 406 22 the the DT cord-021413-1ht1xm88 406 23 virions virion NNS cord-021413-1ht1xm88 406 24 collect collect VBP cord-021413-1ht1xm88 406 25 in in IN cord-021413-1ht1xm88 406 26 cytoplasmic cytoplasmic JJ cord-021413-1ht1xm88 406 27 vesicles vesicle NNS cord-021413-1ht1xm88 406 28 of of IN cord-021413-1ht1xm88 406 29 diverse diverse JJ cord-021413-1ht1xm88 406 30 size size NN cord-021413-1ht1xm88 406 31 , , , cord-021413-1ht1xm88 406 32 that that IN cord-021413-1ht1xm88 406 33 particles particle NNS cord-021413-1ht1xm88 406 34 may may MD cord-021413-1ht1xm88 406 35 also also RB cord-021413-1ht1xm88 406 36 be be VB cord-021413-1ht1xm88 406 37 seen see VBN cord-021413-1ht1xm88 406 38 in in IN cord-021413-1ht1xm88 406 39 the the DT cord-021413-1ht1xm88 406 40 matrix matrix NN cord-021413-1ht1xm88 406 41 outside outside IN cord-021413-1ht1xm88 406 42 of of IN cord-021413-1ht1xm88 406 43 the the DT cord-021413-1ht1xm88 406 44 endoplasmic endoplasmic NN cord-021413-1ht1xm88 406 45 reticulum reticulum NN cord-021413-1ht1xm88 406 46 as as RB cord-021413-1ht1xm88 406 47 well well RB cord-021413-1ht1xm88 406 48 as as IN cord-021413-1ht1xm88 406 49 in in IN cord-021413-1ht1xm88 406 50 the the DT cord-021413-1ht1xm88 406 51 Golgi Golgi NNP cord-021413-1ht1xm88 406 52 apparatus apparatus NN cord-021413-1ht1xm88 406 53 , , , cord-021413-1ht1xm88 406 54 and and CC cord-021413-1ht1xm88 406 55 that that IN cord-021413-1ht1xm88 406 56 they -PRON- PRP cord-021413-1ht1xm88 406 57 are be VBP cord-021413-1ht1xm88 406 58 not not RB cord-021413-1ht1xm88 406 59 observed observe VBN cord-021413-1ht1xm88 406 60 in in IN cord-021413-1ht1xm88 406 61 the the DT cord-021413-1ht1xm88 406 62 nucleus nucleus NN cord-021413-1ht1xm88 406 63 . . . cord-021413-1ht1xm88 407 1 In in IN cord-021413-1ht1xm88 407 2 the the DT cord-021413-1ht1xm88 407 3 main main JJ cord-021413-1ht1xm88 407 4 , , , cord-021413-1ht1xm88 407 5 replication replication NN cord-021413-1ht1xm88 407 6 involves involve VBZ cord-021413-1ht1xm88 407 7 budding bud VBG cord-021413-1ht1xm88 407 8 into into IN cord-021413-1ht1xm88 407 9 cytoplasmic cytoplasmic JJ cord-021413-1ht1xm88 407 10 cis cis NNP cord-021413-1ht1xm88 407 11 temae temae NNP cord-021413-1ht1xm88 407 12 , , , cord-021413-1ht1xm88 407 13 but but CC cord-021413-1ht1xm88 407 14 tubular tubular JJ cord-021413-1ht1xm88 407 15 structures structure NNS cord-021413-1ht1xm88 407 16 have have VBP cord-021413-1ht1xm88 407 17 also also RB cord-021413-1ht1xm88 407 18 been be VBN cord-021413-1ht1xm88 407 19 seen see VBN cord-021413-1ht1xm88 407 20 within within IN cord-021413-1ht1xm88 407 21 the the DT cord-021413-1ht1xm88 407 22 cytoplasm cytoplasm NN cord-021413-1ht1xm88 407 23 during during IN cord-021413-1ht1xm88 407 24 virus virus NN cord-021413-1ht1xm88 407 25 formation formation NN cord-021413-1ht1xm88 407 26 ( ( -LRB- cord-021413-1ht1xm88 407 27 Ruebner Ruebner NNP cord-021413-1ht1xm88 407 28 et et NNP cord-021413-1ht1xm88 407 29 al al NNP cord-021413-1ht1xm88 407 30 . . NNP cord-021413-1ht1xm88 407 31 , , , cord-021413-1ht1xm88 407 32 1967 1967 CD cord-021413-1ht1xm88 407 33 ; ; : cord-021413-1ht1xm88 407 34 Stan Stan NNP cord-021413-1ht1xm88 407 35 di di NNP cord-021413-1ht1xm88 407 36 α/. α/. NNP cord-021413-1ht1xm88 407 37 , , , cord-021413-1ht1xm88 407 38 1960 1960 CD cord-021413-1ht1xm88 407 39 ; ; : cord-021413-1ht1xm88 407 40 Watanabe Watanabe NNP cord-021413-1ht1xm88 407 41 , , , cord-021413-1ht1xm88 407 42 1969a 1969a CD cord-021413-1ht1xm88 407 43 , , , cord-021413-1ht1xm88 407 44 b b LS cord-021413-1ht1xm88 407 45 ) ) -RRB- cord-021413-1ht1xm88 407 46 . . . cord-021413-1ht1xm88 408 1 Wilsnack Wilsnack NNP cord-021413-1ht1xm88 408 2 ( ( -LRB- cord-021413-1ht1xm88 408 3 1971 1971 CD cord-021413-1ht1xm88 408 4 ) ) -RRB- cord-021413-1ht1xm88 408 5 , , , cord-021413-1ht1xm88 408 6 confirming confirm VBG cord-021413-1ht1xm88 408 7 the the DT cord-021413-1ht1xm88 408 8 work work NN cord-021413-1ht1xm88 408 9 of of IN cord-021413-1ht1xm88 408 10 Boss Boss NNP cord-021413-1ht1xm88 408 11 and and CC cord-021413-1ht1xm88 408 12 Jones Jones NNP cord-021413-1ht1xm88 408 13 ( ( -LRB- cord-021413-1ht1xm88 408 14 1963 1963 CD cord-021413-1ht1xm88 408 15 ) ) -RRB- cord-021413-1ht1xm88 408 16 , , , cord-021413-1ht1xm88 408 17 elicited elicit VBD cord-021413-1ht1xm88 408 18 immunofluorescent immunofluorescent NN cord-021413-1ht1xm88 408 19 antigen antigen NN cord-021413-1ht1xm88 408 20 staining stain VBG cord-021413-1ht1xm88 408 21 in in IN cord-021413-1ht1xm88 408 22 sinusoidal sinusoidal JJ cord-021413-1ht1xm88 408 23 lining lining NN cord-021413-1ht1xm88 408 24 cells cell NNS cord-021413-1ht1xm88 408 25 in in IN cord-021413-1ht1xm88 408 26 necrotic necrotic JJ cord-021413-1ht1xm88 408 27 liver liver NN cord-021413-1ht1xm88 408 28 foci foci NN cord-021413-1ht1xm88 408 29 of of IN cord-021413-1ht1xm88 408 30 weanling weanle VBG cord-021413-1ht1xm88 408 31 mice mouse NNS cord-021413-1ht1xm88 408 32 within within IN cord-021413-1ht1xm88 408 33 24 24 CD cord-021413-1ht1xm88 408 34 hr hr NN cord-021413-1ht1xm88 408 35 after after IN cord-021413-1ht1xm88 408 36 intraperitoneal intraperitoneal JJ cord-021413-1ht1xm88 408 37 inoculation inoculation NN cord-021413-1ht1xm88 408 38 of of IN cord-021413-1ht1xm88 408 39 the the DT cord-021413-1ht1xm88 408 40 A59 A59 NNP cord-021413-1ht1xm88 408 41 strain strain NN cord-021413-1ht1xm88 408 42 . . . cord-021413-1ht1xm88 409 1 Stainable stainable JJ cord-021413-1ht1xm88 409 2 antigen antigen NN cord-021413-1ht1xm88 409 3 in in IN cord-021413-1ht1xm88 409 4 intestinal intestinal JJ cord-021413-1ht1xm88 409 5 impression impression NN cord-021413-1ht1xm88 409 6 smears smear NNS cord-021413-1ht1xm88 409 7 of of IN cord-021413-1ht1xm88 409 8 mice mouse NNS cord-021413-1ht1xm88 409 9 in in IN cord-021413-1ht1xm88 409 10 fected fecte VBN cord-021413-1ht1xm88 409 11 by by IN cord-021413-1ht1xm88 409 12 cage cage NN cord-021413-1ht1xm88 409 13 contact contact NN cord-021413-1ht1xm88 409 14 was be VBD cord-021413-1ht1xm88 409 15 also also RB cord-021413-1ht1xm88 409 16 demonstrated demonstrate VBN cord-021413-1ht1xm88 409 17 . . . cord-021413-1ht1xm88 410 1 Piazza Piazza NNP cord-021413-1ht1xm88 410 2 et et FW cord-021413-1ht1xm88 410 3 al al NNP cord-021413-1ht1xm88 410 4 . . . cord-021413-1ht1xm88 411 1 ( ( -LRB- cord-021413-1ht1xm88 411 2 1967 1967 CD cord-021413-1ht1xm88 411 3 ) ) -RRB- cord-021413-1ht1xm88 411 4 examined examine VBD cord-021413-1ht1xm88 411 5 the the DT cord-021413-1ht1xm88 411 6 fate fate NN cord-021413-1ht1xm88 411 7 of of IN cord-021413-1ht1xm88 411 8 MHV3 MHV3 NNP cord-021413-1ht1xm88 411 9 after after IN cord-021413-1ht1xm88 411 10 in in IN cord-021413-1ht1xm88 411 11 travenous travenous JJ cord-021413-1ht1xm88 411 12 inoculation inoculation NN cord-021413-1ht1xm88 411 13 . . . cord-021413-1ht1xm88 412 1 The the DT cord-021413-1ht1xm88 412 2 agent agent NN cord-021413-1ht1xm88 412 3 was be VBD cord-021413-1ht1xm88 412 4 not not RB cord-021413-1ht1xm88 412 5 demonstrable demonstrable JJ cord-021413-1ht1xm88 412 6 be be VB cord-021413-1ht1xm88 412 7 tween tween NN cord-021413-1ht1xm88 412 8 40 40 CD cord-021413-1ht1xm88 412 9 min min NN cord-021413-1ht1xm88 412 10 and and CC cord-021413-1ht1xm88 412 11 3.5 3.5 CD cord-021413-1ht1xm88 412 12 hr hr NN cord-021413-1ht1xm88 412 13 , , , cord-021413-1ht1xm88 412 14 when when WRB cord-021413-1ht1xm88 412 15 it -PRON- PRP cord-021413-1ht1xm88 412 16 appeared appear VBD cord-021413-1ht1xm88 412 17 first first RB cord-021413-1ht1xm88 412 18 in in IN cord-021413-1ht1xm88 412 19 the the DT cord-021413-1ht1xm88 412 20 spleen spleen NN cord-021413-1ht1xm88 412 21 , , , cord-021413-1ht1xm88 412 22 then then RB cord-021413-1ht1xm88 412 23 in in IN cord-021413-1ht1xm88 412 24 the the DT cord-021413-1ht1xm88 412 25 liver liver NN cord-021413-1ht1xm88 412 26 ( ( -LRB- cord-021413-1ht1xm88 412 27 4 4 CD cord-021413-1ht1xm88 412 28 hr hr NN cord-021413-1ht1xm88 412 29 ) ) -RRB- cord-021413-1ht1xm88 412 30 and and CC cord-021413-1ht1xm88 412 31 blood blood NN cord-021413-1ht1xm88 412 32 ( ( -LRB- cord-021413-1ht1xm88 412 33 4.5 4.5 CD cord-021413-1ht1xm88 412 34 hr hr NN cord-021413-1ht1xm88 412 35 ) ) -RRB- cord-021413-1ht1xm88 412 36 . . . cord-021413-1ht1xm88 413 1 At at IN cord-021413-1ht1xm88 413 2 5 5 CD cord-021413-1ht1xm88 413 3 hr hr NN cord-021413-1ht1xm88 413 4 it -PRON- PRP cord-021413-1ht1xm88 413 5 was be VBD cord-021413-1ht1xm88 413 6 recoverable recoverable JJ cord-021413-1ht1xm88 413 7 from from IN cord-021413-1ht1xm88 413 8 brain brain NN cord-021413-1ht1xm88 413 9 and and CC cord-021413-1ht1xm88 413 10 kidney kidney NN cord-021413-1ht1xm88 413 11 . . . cord-021413-1ht1xm88 414 1 High high JJ cord-021413-1ht1xm88 414 2 titers titer NNS cord-021413-1ht1xm88 414 3 were be VBD cord-021413-1ht1xm88 414 4 then then RB cord-021413-1ht1xm88 414 5 reached reach VBN cord-021413-1ht1xm88 414 6 in in IN cord-021413-1ht1xm88 414 7 all all DT cord-021413-1ht1xm88 414 8 organs organ NNS cord-021413-1ht1xm88 414 9 . . . cord-021413-1ht1xm88 415 1 Barinsky Barinsky NNP cord-021413-1ht1xm88 415 2 and and CC cord-021413-1ht1xm88 415 3 Dementiev Dementiev NNP cord-021413-1ht1xm88 415 4 ( ( -LRB- cord-021413-1ht1xm88 415 5 1968 1968 CD cord-021413-1ht1xm88 415 6 ) ) -RRB- cord-021413-1ht1xm88 416 1 Thereafter thereafter RB cord-021413-1ht1xm88 416 2 , , , cord-021413-1ht1xm88 416 3 the the DT cord-021413-1ht1xm88 416 4 cells cell NNS cord-021413-1ht1xm88 416 5 of of IN cord-021413-1ht1xm88 416 6 the the DT cord-021413-1ht1xm88 416 7 olfactory olfactory JJ cord-021413-1ht1xm88 416 8 bulb bulb NN cord-021413-1ht1xm88 416 9 and and CC cord-021413-1ht1xm88 416 10 other other JJ cord-021413-1ht1xm88 416 11 brain brain NN cord-021413-1ht1xm88 417 1 re re IN cord-021413-1ht1xm88 417 2 gions gion NNS cord-021413-1ht1xm88 417 3 are be VBP cord-021413-1ht1xm88 417 4 affected affect VBN cord-021413-1ht1xm88 417 5 . . . cord-021413-1ht1xm88 418 1 A a DT cord-021413-1ht1xm88 418 2 number number NN cord-021413-1ht1xm88 418 3 of of IN cord-021413-1ht1xm88 418 4 cell cell NN cord-021413-1ht1xm88 418 5 systems system NNS cord-021413-1ht1xm88 418 6 have have VBP cord-021413-1ht1xm88 418 7 been be VBN cord-021413-1ht1xm88 418 8 successfully successfully RB cord-021413-1ht1xm88 418 9 employed employ VBN cord-021413-1ht1xm88 418 10 for for IN cord-021413-1ht1xm88 418 11 in in FW cord-021413-1ht1xm88 418 12 vitro vitro FW cord-021413-1ht1xm88 418 13 growth growth NN cord-021413-1ht1xm88 418 14 of of IN cord-021413-1ht1xm88 418 15 mouse mouse NN cord-021413-1ht1xm88 418 16 hepatitis hepatitis NN cord-021413-1ht1xm88 418 17 viruses virus NNS cord-021413-1ht1xm88 418 18 : : : cord-021413-1ht1xm88 418 19 MHV MHV NNP cord-021413-1ht1xm88 418 20 - - HYPH cord-021413-1ht1xm88 418 21 C C NNP cord-021413-1ht1xm88 418 22 in in IN cord-021413-1ht1xm88 418 23 mouse mouse NN cord-021413-1ht1xm88 418 24 embryo embryo NN cord-021413-1ht1xm88 418 25 explants explant NNS cord-021413-1ht1xm88 418 26 ( ( -LRB- cord-021413-1ht1xm88 418 27 Mosley Mosley NNP cord-021413-1ht1xm88 418 28 , , , cord-021413-1ht1xm88 418 29 1961 1961 CD cord-021413-1ht1xm88 418 30 ) ) -RRB- cord-021413-1ht1xm88 418 31 ; ; : cord-021413-1ht1xm88 418 32 MHVl MHVl NNS cord-021413-1ht1xm88 418 33 in in IN cord-021413-1ht1xm88 418 34 newborn newborn JJ cord-021413-1ht1xm88 418 35 mouse mouse NN cord-021413-1ht1xm88 418 36 kidney kidney NN cord-021413-1ht1xm88 418 37 explants explant NNS cord-021413-1ht1xm88 418 38 ( ( -LRB- cord-021413-1ht1xm88 418 39 Starr Starr NNP cord-021413-1ht1xm88 418 40 and and CC cord-021413-1ht1xm88 418 41 Pollard Pollard NNP cord-021413-1ht1xm88 418 42 , , , cord-021413-1ht1xm88 418 43 1959 1959 CD cord-021413-1ht1xm88 418 44 ) ) -RRB- cord-021413-1ht1xm88 418 45 ; ; : cord-021413-1ht1xm88 418 46 MHV MHV NNP cord-021413-1ht1xm88 418 47 - - HYPH cord-021413-1ht1xm88 418 48 S S NNP cord-021413-1ht1xm88 418 49 in in IN cord-021413-1ht1xm88 418 50 mouse mouse NN cord-021413-1ht1xm88 418 51 embryo embryo NN cord-021413-1ht1xm88 418 52 explants explant NNS cord-021413-1ht1xm88 418 53 ( ( -LRB- cord-021413-1ht1xm88 418 54 Compels compel NNS cord-021413-1ht1xm88 418 55 , , , cord-021413-1ht1xm88 418 56 1953 1953 CD cord-021413-1ht1xm88 418 57 ) ) -RRB- cord-021413-1ht1xm88 418 58 and and CC cord-021413-1ht1xm88 418 59 in in IN cord-021413-1ht1xm88 418 60 liver liver NN cord-021413-1ht1xm88 418 61 ( ( -LRB- cord-021413-1ht1xm88 418 62 Gallily Gallily NNP cord-021413-1ht1xm88 418 63 et et NNP cord-021413-1ht1xm88 418 64 aL aL NNP cord-021413-1ht1xm88 418 65 , , , cord-021413-1ht1xm88 418 66 1964 1964 CD cord-021413-1ht1xm88 418 67 ) ) -RRB- cord-021413-1ht1xm88 418 68 ; ; : cord-021413-1ht1xm88 418 69 MHV MHV NNP cord-021413-1ht1xm88 418 70 - - HYPH cord-021413-1ht1xm88 418 71 B b NN cord-021413-1ht1xm88 418 72 in in IN cord-021413-1ht1xm88 418 73 liver liver NN cord-021413-1ht1xm88 418 74 cell cell NN cord-021413-1ht1xm88 418 75 monolayers monolayer NNS cord-021413-1ht1xm88 418 76 ( ( -LRB- cord-021413-1ht1xm88 418 77 Paradisi Paradisi NNP cord-021413-1ht1xm88 418 78 and and CC cord-021413-1ht1xm88 418 79 Piccinino Piccinino NNP cord-021413-1ht1xm88 418 80 , , , cord-021413-1ht1xm88 418 81 1968 1968 CD cord-021413-1ht1xm88 418 82 ) ) -RRB- cord-021413-1ht1xm88 418 83 ; ; : cord-021413-1ht1xm88 418 84 MHV3 MHV3 NNP cord-021413-1ht1xm88 418 85 in in IN cord-021413-1ht1xm88 418 86 liver liver NN cord-021413-1ht1xm88 418 87 explants explant NNS cord-021413-1ht1xm88 418 88 ( ( -LRB- cord-021413-1ht1xm88 418 89 Vainio Vainio NNP cord-021413-1ht1xm88 418 90 , , , cord-021413-1ht1xm88 418 91 1961 1961 CD cord-021413-1ht1xm88 418 92 ) ) -RRB- cord-021413-1ht1xm88 418 93 ; ; : cord-021413-1ht1xm88 418 94 MHV MHV NNP cord-021413-1ht1xm88 418 95 - - HYPH cord-021413-1ht1xm88 418 96 B b NN cord-021413-1ht1xm88 418 97 in in IN cord-021413-1ht1xm88 418 98 liver liver NN cord-021413-1ht1xm88 418 99 cells cell NNS cord-021413-1ht1xm88 419 1 ( ( -LRB- cord-021413-1ht1xm88 419 2 Miyazaki Miyazaki NNP cord-021413-1ht1xm88 419 3 et et NNP cord-021413-1ht1xm88 419 4 aL aL NNP cord-021413-1ht1xm88 419 5 , , , cord-021413-1ht1xm88 419 6 1957 1957 CD cord-021413-1ht1xm88 419 7 ) ) -RRB- cord-021413-1ht1xm88 419 8 ; ; : cord-021413-1ht1xm88 419 9 MHV2 MHV2 NNP cord-021413-1ht1xm88 419 10 and and CC cord-021413-1ht1xm88 419 11 MHV3 MHV3 NNP cord-021413-1ht1xm88 419 12 in in IN cord-021413-1ht1xm88 419 13 DBT DBT NNP cord-021413-1ht1xm88 419 14 cells cell NNS cord-021413-1ht1xm88 420 1 ( ( -LRB- cord-021413-1ht1xm88 420 2 Hirano Hirano NNP cord-021413-1ht1xm88 420 3 et et NNP cord-021413-1ht1xm88 420 4 aL aL NNP cord-021413-1ht1xm88 420 5 , , , cord-021413-1ht1xm88 420 6 1978 1978 CD cord-021413-1ht1xm88 420 7 ; ; : cord-021413-1ht1xm88 420 8 Takayama Takayama NNP cord-021413-1ht1xm88 420 9 and and CC cord-021413-1ht1xm88 420 10 Kim Kim NNP cord-021413-1ht1xm88 420 11 , , , cord-021413-1ht1xm88 420 12 1978 1978 CD cord-021413-1ht1xm88 420 13 ) ) -RRB- cord-021413-1ht1xm88 420 14 ; ; : cord-021413-1ht1xm88 420 15 and and CC cord-021413-1ht1xm88 420 16 various various JJ cord-021413-1ht1xm88 420 17 strains strain NNS cord-021413-1ht1xm88 420 18 in in IN cord-021413-1ht1xm88 420 19 NCTC NCTC NNP cord-021413-1ht1xm88 420 20 1469 1469 CD cord-021413-1ht1xm88 420 21 cells cell NNS cord-021413-1ht1xm88 421 1 ( ( -LRB- cord-021413-1ht1xm88 421 2 David David NNP cord-021413-1ht1xm88 421 3 - - HYPH cord-021413-1ht1xm88 421 4 Ferreira Ferreira NNP cord-021413-1ht1xm88 421 5 and and CC cord-021413-1ht1xm88 421 6 Manaker Manaker NNP cord-021413-1ht1xm88 421 7 , , , cord-021413-1ht1xm88 421 8 1965 1965 CD cord-021413-1ht1xm88 421 9 ; ; : cord-021413-1ht1xm88 422 1 Wilsnack Wilsnack NNP cord-021413-1ht1xm88 422 2 etaL etaL NNP cord-021413-1ht1xm88 422 3 , , , cord-021413-1ht1xm88 422 4 1971 1971 CD cord-021413-1ht1xm88 422 5 ; ; : cord-021413-1ht1xm88 422 6 Hartley Hartley NNP cord-021413-1ht1xm88 422 7 and and CC cord-021413-1ht1xm88 422 8 Rowe Rowe NNP cord-021413-1ht1xm88 422 9 , , , cord-021413-1ht1xm88 422 10 1963 1963 CD cord-021413-1ht1xm88 422 11 ) ) -RRB- cord-021413-1ht1xm88 422 12 . . . cord-021413-1ht1xm88 423 1 Mallucci Mallucci NNP cord-021413-1ht1xm88 423 2 ( ( -LRB- cord-021413-1ht1xm88 423 3 1965 1965 CD cord-021413-1ht1xm88 423 4 ) ) -RRB- cord-021413-1ht1xm88 423 5 , , , cord-021413-1ht1xm88 423 6 Seamer Seamer NNP cord-021413-1ht1xm88 423 7 ( ( -LRB- cord-021413-1ht1xm88 423 8 1965 1965 CD cord-021413-1ht1xm88 423 9 ) ) -RRB- cord-021413-1ht1xm88 423 10 , , , cord-021413-1ht1xm88 423 11 and and CC cord-021413-1ht1xm88 423 12 Lewis Lewis NNP cord-021413-1ht1xm88 423 13 and and CC cord-021413-1ht1xm88 423 14 Starr Starr NNP cord-021413-1ht1xm88 423 15 ( ( -LRB- cord-021413-1ht1xm88 423 16 1972 1972 CD cord-021413-1ht1xm88 423 17 ) ) -RRB- cord-021413-1ht1xm88 423 18 described describe VBD cord-021413-1ht1xm88 423 19 syncytium syncytium NN cord-021413-1ht1xm88 423 20 formation formation NN cord-021413-1ht1xm88 423 21 by by IN cord-021413-1ht1xm88 423 22 MHV MHV NNP cord-021413-1ht1xm88 423 23 in in IN cord-021413-1ht1xm88 423 24 mouse mouse NN cord-021413-1ht1xm88 423 25 macrophage macrophage NN cord-021413-1ht1xm88 423 26 cultures culture NNS cord-021413-1ht1xm88 423 27 , , , cord-021413-1ht1xm88 423 28 and and CC cord-021413-1ht1xm88 423 29 a a DT cord-021413-1ht1xm88 423 30 plaque plaque NN cord-021413-1ht1xm88 423 31 assay assay NN cord-021413-1ht1xm88 423 32 for for IN cord-021413-1ht1xm88 423 33 MHV2 MHV2 NNP cord-021413-1ht1xm88 423 34 in in IN cord-021413-1ht1xm88 423 35 primary primary JJ cord-021413-1ht1xm88 423 36 peritoneal peritoneal JJ cord-021413-1ht1xm88 423 37 macrophage macrophage NN cord-021413-1ht1xm88 423 38 cultures culture NNS cord-021413-1ht1xm88 423 39 was be VBD cord-021413-1ht1xm88 423 40 described describe VBN cord-021413-1ht1xm88 423 41 by by IN cord-021413-1ht1xm88 423 42 Shif Shif NNP cord-021413-1ht1xm88 423 43 and and CC cord-021413-1ht1xm88 423 44 Bang Bang NNP cord-021413-1ht1xm88 423 45 ( ( -LRB- cord-021413-1ht1xm88 423 46 1966 1966 CD cord-021413-1ht1xm88 423 47 ) ) -RRB- cord-021413-1ht1xm88 423 48 . . . cord-021413-1ht1xm88 424 1 Laufs Laufs NNP cord-021413-1ht1xm88 424 2 ( ( -LRB- cord-021413-1ht1xm88 424 3 1967 1967 CD cord-021413-1ht1xm88 424 4 ) ) -RRB- cord-021413-1ht1xm88 424 5 also also RB cord-021413-1ht1xm88 424 6 described describe VBD cord-021413-1ht1xm88 424 7 multinucleated multinucleate VBN cord-021413-1ht1xm88 424 8 giant giant JJ cord-021413-1ht1xm88 424 9 cells cell NNS cord-021413-1ht1xm88 424 10 with with IN cord-021413-1ht1xm88 424 11 as as RB cord-021413-1ht1xm88 424 12 many many JJ cord-021413-1ht1xm88 424 13 as as IN cord-021413-1ht1xm88 424 14 200 200 CD cord-021413-1ht1xm88 424 15 nuclei nucleus NNS cord-021413-1ht1xm88 424 16 per per IN cord-021413-1ht1xm88 424 17 cell cell NN cord-021413-1ht1xm88 424 18 in in IN cord-021413-1ht1xm88 424 19 macrophage macrophage NN cord-021413-1ht1xm88 424 20 cultures culture NNS cord-021413-1ht1xm88 424 21 infected infect VBN cord-021413-1ht1xm88 424 22 with with IN cord-021413-1ht1xm88 424 23 MHV3 MHV3 NNP cord-021413-1ht1xm88 424 24 . . . cord-021413-1ht1xm88 425 1 Using use VBG cord-021413-1ht1xm88 425 2 autoradiography autoradiography NNP cord-021413-1ht1xm88 425 3 , , , cord-021413-1ht1xm88 425 4 he -PRON- PRP cord-021413-1ht1xm88 425 5 ascertained ascertain VBD cord-021413-1ht1xm88 425 6 that that IN cord-021413-1ht1xm88 425 7 there there EX cord-021413-1ht1xm88 425 8 was be VBD cord-021413-1ht1xm88 425 9 no no DT cord-021413-1ht1xm88 425 10 DNA dna NN cord-021413-1ht1xm88 425 11 synthesis synthesis NN cord-021413-1ht1xm88 425 12 in in IN cord-021413-1ht1xm88 425 13 them -PRON- PRP cord-021413-1ht1xm88 425 14 and and CC cord-021413-1ht1xm88 425 15 that that IN cord-021413-1ht1xm88 425 16 they -PRON- PRP cord-021413-1ht1xm88 425 17 originated originate VBD cord-021413-1ht1xm88 425 18 from from IN cord-021413-1ht1xm88 425 19 cell cell NN cord-021413-1ht1xm88 425 20 fusion fusion NN cord-021413-1ht1xm88 425 21 . . . cord-021413-1ht1xm88 426 1 Macrophages macrophage NNS cord-021413-1ht1xm88 426 2 derived derive VBN cord-021413-1ht1xm88 426 3 from from IN cord-021413-1ht1xm88 426 4 either either CC cord-021413-1ht1xm88 426 5 liver liver NN cord-021413-1ht1xm88 426 6 or or CC cord-021413-1ht1xm88 426 7 peritoneal peritoneal JJ cord-021413-1ht1xm88 426 8 wash wash NN cord-021413-1ht1xm88 426 9 ings ing NNS cord-021413-1ht1xm88 426 10 are be VBP cord-021413-1ht1xm88 426 11 of of IN cord-021413-1ht1xm88 426 12 enormous enormous JJ cord-021413-1ht1xm88 426 13 interest interest NN cord-021413-1ht1xm88 426 14 for for IN cord-021413-1ht1xm88 426 15 the the DT cord-021413-1ht1xm88 426 16 question question NN cord-021413-1ht1xm88 426 17 of of IN cord-021413-1ht1xm88 426 18 host host NN cord-021413-1ht1xm88 426 19 cell cell NN cord-021413-1ht1xm88 426 20 - - HYPH cord-021413-1ht1xm88 426 21 vims vim VBN cord-021413-1ht1xm88 426 22 interactions interaction NNS cord-021413-1ht1xm88 426 23 . . . cord-021413-1ht1xm88 427 1 Bang Bang NNP cord-021413-1ht1xm88 427 2 and and CC cord-021413-1ht1xm88 427 3 Warwick Warwick NNP cord-021413-1ht1xm88 427 4 ( ( -LRB- cord-021413-1ht1xm88 427 5 1959 1959 CD cord-021413-1ht1xm88 427 6 , , , cord-021413-1ht1xm88 427 7 1960 1960 CD cord-021413-1ht1xm88 427 8 ) ) -RRB- cord-021413-1ht1xm88 428 1 Macrophages macrophage NNS cord-021413-1ht1xm88 428 2 from from IN cord-021413-1ht1xm88 428 3 the the DT cord-021413-1ht1xm88 428 4 mice mice NN cord-021413-1ht1xm88 428 5 mirror mirror VBP cord-021413-1ht1xm88 428 6 these these DT cord-021413-1ht1xm88 428 7 changes change NNS cord-021413-1ht1xm88 428 8 in in IN cord-021413-1ht1xm88 428 9 resistance resistance NN cord-021413-1ht1xm88 428 10 as as IN cord-021413-1ht1xm88 428 11 the the DT cord-021413-1ht1xm88 428 12 animals animal NNS cord-021413-1ht1xm88 428 13 age age NN cord-021413-1ht1xm88 428 14 . . . cord-021413-1ht1xm88 429 1 Kantoch Kantoch NNP cord-021413-1ht1xm88 429 2 et et FW cord-021413-1ht1xm88 429 3 al al NNP cord-021413-1ht1xm88 429 4 . . . cord-021413-1ht1xm88 430 1 ( ( -LRB- cord-021413-1ht1xm88 430 2 1963 1963 CD cord-021413-1ht1xm88 430 3 ) ) -RRB- cord-021413-1ht1xm88 430 4 determined determine VBD cord-021413-1ht1xm88 430 5 that that IN cord-021413-1ht1xm88 430 6 temporary temporary JJ cord-021413-1ht1xm88 430 7 susceptibility susceptibility NN cord-021413-1ht1xm88 430 8 could could MD cord-021413-1ht1xm88 430 9 be be VB cord-021413-1ht1xm88 430 10 induced induce VBN cord-021413-1ht1xm88 430 11 in in IN cord-021413-1ht1xm88 430 12 resistant resistant JJ cord-021413-1ht1xm88 430 13 cells cell NNS cord-021413-1ht1xm88 430 14 in in IN cord-021413-1ht1xm88 430 15 culture culture NN cord-021413-1ht1xm88 430 16 if if IN cord-021413-1ht1xm88 430 17 they -PRON- PRP cord-021413-1ht1xm88 430 18 were be VBD cord-021413-1ht1xm88 430 19 exposed expose VBN cord-021413-1ht1xm88 430 20 to to IN cord-021413-1ht1xm88 430 21 homogenates homogenate NNS cord-021413-1ht1xm88 430 22 of of IN cord-021413-1ht1xm88 430 23 susceptible susceptible JJ cord-021413-1ht1xm88 430 24 cells cell NNS cord-021413-1ht1xm88 430 25 , , , cord-021413-1ht1xm88 430 26 and and CC cord-021413-1ht1xm88 430 27 Gallily Gallily NNP cord-021413-1ht1xm88 430 28 et et NNP cord-021413-1ht1xm88 430 29 al al NNP cord-021413-1ht1xm88 430 30 . . . cord-021413-1ht1xm88 431 1 ( ( -LRB- cord-021413-1ht1xm88 431 2 1964 1964 CD cord-021413-1ht1xm88 431 3 ) ) -RRB- cord-021413-1ht1xm88 431 4 showed show VBD cord-021413-1ht1xm88 431 5 that that IN cord-021413-1ht1xm88 431 6 macrophages macrophage NNS cord-021413-1ht1xm88 431 7 from from IN cord-021413-1ht1xm88 431 8 genetically genetically RB cord-021413-1ht1xm88 431 9 resistant resistant JJ cord-021413-1ht1xm88 431 10 mice mouse NNS cord-021413-1ht1xm88 431 11 treated treat VBN cord-021413-1ht1xm88 431 12 with with IN cord-021413-1ht1xm88 431 13 cortisone cortisone NN cord-021413-1ht1xm88 431 14 to to TO cord-021413-1ht1xm88 431 15 enhance enhance VB cord-021413-1ht1xm88 431 16 susceptibility susceptibility NN cord-021413-1ht1xm88 431 17 behave behave VB cord-021413-1ht1xm88 431 18 in in IN cord-021413-1ht1xm88 431 19 culture culture NN cord-021413-1ht1xm88 431 20 as as IN cord-021413-1ht1xm88 431 21 if if IN cord-021413-1ht1xm88 431 22 they -PRON- PRP cord-021413-1ht1xm88 431 23 were be VBD cord-021413-1ht1xm88 431 24 from from IN cord-021413-1ht1xm88 431 25 susceptible susceptible JJ cord-021413-1ht1xm88 431 26 animals animal NNS cord-021413-1ht1xm88 431 27 . . . cord-021413-1ht1xm88 432 1 Macrophages macrophage NNS cord-021413-1ht1xm88 432 2 from from IN cord-021413-1ht1xm88 432 3 mice mouse NNS cord-021413-1ht1xm88 432 4 susceptible susceptible JJ cord-021413-1ht1xm88 432 5 to to IN cord-021413-1ht1xm88 432 6 MHV2 MHV2 NNP cord-021413-1ht1xm88 432 7 virus virus NN cord-021413-1ht1xm88 432 8 can can MD cord-021413-1ht1xm88 432 9 be be VB cord-021413-1ht1xm88 432 10 converted convert VBN cord-021413-1ht1xm88 432 11 to to IN cord-021413-1ht1xm88 432 12 resistance resistance NN cord-021413-1ht1xm88 432 13 by by IN cord-021413-1ht1xm88 432 14 the the DT cord-021413-1ht1xm88 432 15 intraperitoneal intraperitoneal JJ cord-021413-1ht1xm88 432 16 inoculation inoculation NN cord-021413-1ht1xm88 432 17 of of IN cord-021413-1ht1xm88 432 18 concanavalin concanavalin NNP cord-021413-1ht1xm88 432 19 A A NNP cord-021413-1ht1xm88 432 20 in in IN cord-021413-1ht1xm88 432 21 the the DT cord-021413-1ht1xm88 432 22 donor donor NN cord-021413-1ht1xm88 432 23 mice mouse NNS cord-021413-1ht1xm88 432 24 . . . cord-021413-1ht1xm88 433 1 This this DT cord-021413-1ht1xm88 433 2 enhanced enhance VBN cord-021413-1ht1xm88 433 3 resistance resistance NN cord-021413-1ht1xm88 433 4 is be VBZ cord-021413-1ht1xm88 433 5 also also RB cord-021413-1ht1xm88 433 6 expressed express VBN cord-021413-1ht1xm88 433 7 in in IN cord-021413-1ht1xm88 433 8 vivo vivo FW cord-021413-1ht1xm88 433 9 ( ( -LRB- cord-021413-1ht1xm88 433 10 Weiser Weiser NNP cord-021413-1ht1xm88 433 11 and and CC cord-021413-1ht1xm88 433 12 Bang Bang NNP cord-021413-1ht1xm88 433 13 , , , cord-021413-1ht1xm88 433 14 1977 1977 CD cord-021413-1ht1xm88 433 15 ) ) -RRB- cord-021413-1ht1xm88 433 16 . . . cord-021413-1ht1xm88 434 1 Cheever Cheever NNP cord-021413-1ht1xm88 434 2 etal etal NNP cord-021413-1ht1xm88 434 3 . . . cord-021413-1ht1xm88 435 1 ( ( -LRB- cord-021413-1ht1xm88 435 2 1949 1949 CD cord-021413-1ht1xm88 435 3 ) ) -RRB- cord-021413-1ht1xm88 435 4 , , , cord-021413-1ht1xm88 435 5 Nelson Nelson NNP cord-021413-1ht1xm88 435 6 ( ( -LRB- cord-021413-1ht1xm88 435 7 1952b 1952b CD cord-021413-1ht1xm88 435 8 ) ) -RRB- cord-021413-1ht1xm88 435 9 , , , cord-021413-1ht1xm88 435 10 and and CC cord-021413-1ht1xm88 435 11 Kraft Kraft NNP cord-021413-1ht1xm88 435 12 ( ( -LRB- cord-021413-1ht1xm88 435 13 1962a 1962a CD cord-021413-1ht1xm88 435 14 ) ) -RRB- cord-021413-1ht1xm88 436 1 In in IN cord-021413-1ht1xm88 436 2 suckling suckle VBG cord-021413-1ht1xm88 436 3 mice mouse NNS cord-021413-1ht1xm88 436 4 , , , cord-021413-1ht1xm88 436 5 rapid rapid JJ cord-021413-1ht1xm88 436 6 wasting wasting NN cord-021413-1ht1xm88 436 7 with with IN cord-021413-1ht1xm88 436 8 or or CC cord-021413-1ht1xm88 436 9 without without IN cord-021413-1ht1xm88 436 10 neurologic neurologic JJ cord-021413-1ht1xm88 436 11 signs sign NNS cord-021413-1ht1xm88 436 12 may may MD cord-021413-1ht1xm88 436 13 take take VB cord-021413-1ht1xm88 436 14 place place NN cord-021413-1ht1xm88 436 15 , , , cord-021413-1ht1xm88 436 16 accompanied accompany VBN cord-021413-1ht1xm88 436 17 in in IN cord-021413-1ht1xm88 436 18 some some DT cord-021413-1ht1xm88 436 19 cases case NNS cord-021413-1ht1xm88 436 20 by by IN cord-021413-1ht1xm88 436 21 diarrhea diarrhea NN cord-021413-1ht1xm88 436 22 , , , cord-021413-1ht1xm88 436 23 inanition inanition NN cord-021413-1ht1xm88 436 24 , , , cord-021413-1ht1xm88 436 25 and and CC cord-021413-1ht1xm88 436 26 dehydration dehydration NN cord-021413-1ht1xm88 436 27 ( ( -LRB- cord-021413-1ht1xm88 436 28 Fig fig NN cord-021413-1ht1xm88 436 29 . . NNP cord-021413-1ht1xm88 436 30 2 2 CD cord-021413-1ht1xm88 436 31 ) ) -RRB- cord-021413-1ht1xm88 436 32 . . . cord-021413-1ht1xm88 437 1 Mortality mortality NN cord-021413-1ht1xm88 437 2 and and CC cord-021413-1ht1xm88 437 3 morbidity morbidity NN cord-021413-1ht1xm88 437 4 are be VBP cord-021413-1ht1xm88 437 5 variable variable JJ cord-021413-1ht1xm88 437 6 , , , cord-021413-1ht1xm88 437 7 ranging range VBG cord-021413-1ht1xm88 437 8 between between IN cord-021413-1ht1xm88 437 9 al al NNP cord-021413-1ht1xm88 437 10 most most JJS cord-021413-1ht1xm88 437 11 0 0 NFP cord-021413-1ht1xm88 437 12 and and CC cord-021413-1ht1xm88 437 13 100 100 CD cord-021413-1ht1xm88 437 14 % % NN cord-021413-1ht1xm88 437 15 depending depend VBG cord-021413-1ht1xm88 437 16 on on IN cord-021413-1ht1xm88 437 17 factors factor NNS cord-021413-1ht1xm88 437 18 like like IN cord-021413-1ht1xm88 437 19 those those DT cord-021413-1ht1xm88 437 20 affecting affect VBG cord-021413-1ht1xm88 437 21 clinical clinical JJ cord-021413-1ht1xm88 437 22 signs sign NNS cord-021413-1ht1xm88 437 23 . . . cord-021413-1ht1xm88 438 1 Of of IN cord-021413-1ht1xm88 438 2 importance importance NN cord-021413-1ht1xm88 438 3 to to IN cord-021413-1ht1xm88 438 4 users user NNS cord-021413-1ht1xm88 438 5 and and CC cord-021413-1ht1xm88 438 6 breeders breeder NNS cord-021413-1ht1xm88 438 7 of of IN cord-021413-1ht1xm88 438 8 mice mouse NNS cord-021413-1ht1xm88 438 9 alike alike RB cord-021413-1ht1xm88 438 10 is be VBZ cord-021413-1ht1xm88 438 11 the the DT cord-021413-1ht1xm88 438 12 fact fact NN cord-021413-1ht1xm88 438 13 that that IN cord-021413-1ht1xm88 438 14 a a DT cord-021413-1ht1xm88 438 15 number number NN cord-021413-1ht1xm88 438 16 of of IN cord-021413-1ht1xm88 438 17 agents agent NNS cord-021413-1ht1xm88 438 18 and and CC cord-021413-1ht1xm88 438 19 procedures procedure NNS cord-021413-1ht1xm88 438 20 are be VBP cord-021413-1ht1xm88 438 21 known know VBN cord-021413-1ht1xm88 438 22 to to TO cord-021413-1ht1xm88 438 23 modify modify VB cord-021413-1ht1xm88 438 24 the the DT cord-021413-1ht1xm88 438 25 reactivity reactivity NN cord-021413-1ht1xm88 438 26 ( ( -LRB- cord-021413-1ht1xm88 438 27 and and CC cord-021413-1ht1xm88 438 28 therefore therefore RB cord-021413-1ht1xm88 438 29 the the DT cord-021413-1ht1xm88 438 30 clinical clinical JJ cord-021413-1ht1xm88 438 31 signs sign NNS cord-021413-1ht1xm88 438 32 ) ) -RRB- cord-021413-1ht1xm88 438 33 of of IN cord-021413-1ht1xm88 438 34 mice mouse NNS cord-021413-1ht1xm88 438 35 to to IN cord-021413-1ht1xm88 438 36 both both CC cord-021413-1ht1xm88 438 37 spontaneous spontaneous JJ cord-021413-1ht1xm88 438 38 and and CC cord-021413-1ht1xm88 438 39 experimental experimental JJ cord-021413-1ht1xm88 438 40 infection infection NN cord-021413-1ht1xm88 438 41 . . . cord-021413-1ht1xm88 439 1 Examples example NNS cord-021413-1ht1xm88 439 2 of of IN cord-021413-1ht1xm88 439 3 these these DT cord-021413-1ht1xm88 439 4 , , , cord-021413-1ht1xm88 439 5 together together RB cord-021413-1ht1xm88 439 6 with with IN cord-021413-1ht1xm88 439 7 pertinent pertinent JJ cord-021413-1ht1xm88 439 8 references reference NNS cord-021413-1ht1xm88 439 9 , , , cord-021413-1ht1xm88 439 10 are be VBP cord-021413-1ht1xm88 439 11 presented present VBN cord-021413-1ht1xm88 439 12 in in IN cord-021413-1ht1xm88 439 13 Table Table NNP cord-021413-1ht1xm88 439 14 I -PRON- PRP cord-021413-1ht1xm88 439 15 . . . cord-021413-1ht1xm88 440 1 LePrévost LePrévost NNP cord-021413-1ht1xm88 440 2 et et NNP cord-021413-1ht1xm88 440 3 al al NNP cord-021413-1ht1xm88 440 4 . . . cord-021413-1ht1xm88 441 1 ( ( -LRB- cord-021413-1ht1xm88 441 2 1975a 1975a CD cord-021413-1ht1xm88 441 3 , , , cord-021413-1ht1xm88 441 4 b b LS cord-021413-1ht1xm88 441 5 ) ) -RRB- cord-021413-1ht1xm88 441 6 have have VBP cord-021413-1ht1xm88 441 7 taken take VBN cord-021413-1ht1xm88 441 8 the the DT cord-021413-1ht1xm88 441 9 view view NN cord-021413-1ht1xm88 441 10 that that IN cord-021413-1ht1xm88 441 11 there there EX cord-021413-1ht1xm88 441 12 are be VBP cord-021413-1ht1xm88 441 13 three three CD cord-021413-1ht1xm88 441 14 types type NNS cord-021413-1ht1xm88 441 15 of of IN cord-021413-1ht1xm88 441 16 sensitivity sensitivity NN cord-021413-1ht1xm88 441 17 to to IN cord-021413-1ht1xm88 441 18 MHV3 MHV3 NNP cord-021413-1ht1xm88 441 19 infection infection NN cord-021413-1ht1xm88 441 20 in in IN cord-021413-1ht1xm88 441 21 mice mouse NNS cord-021413-1ht1xm88 441 22 : : : cord-021413-1ht1xm88 441 23 resis resis NNP cord-021413-1ht1xm88 441 24 tance tance NNP cord-021413-1ht1xm88 441 25 , , , cord-021413-1ht1xm88 441 26 full full JJ cord-021413-1ht1xm88 441 27 susceptibility susceptibility NN cord-021413-1ht1xm88 441 28 , , , cord-021413-1ht1xm88 441 29 and and CC cord-021413-1ht1xm88 441 30 semisusceptibility semisusceptibility NN cord-021413-1ht1xm88 441 31 . . . cord-021413-1ht1xm88 442 1 These these DT cord-021413-1ht1xm88 442 2 are be VBP cord-021413-1ht1xm88 442 3 re re IN cord-021413-1ht1xm88 442 4 flected flecte VBN cord-021413-1ht1xm88 442 5 in in IN cord-021413-1ht1xm88 442 6 the the DT cord-021413-1ht1xm88 442 7 susceptibility susceptibility NN cord-021413-1ht1xm88 442 8 of of IN cord-021413-1ht1xm88 442 9 their -PRON- PRP$ cord-021413-1ht1xm88 442 10 macrophages macrophage NNS cord-021413-1ht1xm88 442 11 Response response NN cord-021413-1ht1xm88 442 12 of of IN cord-021413-1ht1xm88 442 13 nuInu nuInu NNP cord-021413-1ht1xm88 442 14 mice mouse NNS cord-021413-1ht1xm88 442 15 to to IN cord-021413-1ht1xm88 442 16 sheep sheep NN cord-021413-1ht1xm88 442 17 erythrocytes erythrocyte NNS cord-021413-1ht1xm88 442 18 DBA/2 DBA/2 NNP cord-021413-1ht1xm88 442 19 mice mouse NNS cord-021413-1ht1xm88 442 20 , , , cord-021413-1ht1xm88 442 21 on on IN cord-021413-1ht1xm88 442 22 the the DT cord-021413-1ht1xm88 442 23 other other JJ cord-021413-1ht1xm88 442 24 hand hand NN cord-021413-1ht1xm88 442 25 , , , cord-021413-1ht1xm88 442 26 are be VBP cord-021413-1ht1xm88 442 27 regarded regard VBN cord-021413-1ht1xm88 442 28 as as RB cord-021413-1ht1xm88 442 29 fully fully RB cord-021413-1ht1xm88 442 30 suscep suscep NN cord-021413-1ht1xm88 442 31 tible tible NN cord-021413-1ht1xm88 442 32 since since IN cord-021413-1ht1xm88 442 33 deaths death NNS cord-021413-1ht1xm88 442 34 begin begin VBP cord-021413-1ht1xm88 442 35 4 4 CD cord-021413-1ht1xm88 442 36 - - SYM cord-021413-1ht1xm88 442 37 6 6 CD cord-021413-1ht1xm88 442 38 days day NNS cord-021413-1ht1xm88 442 39 after after IN cord-021413-1ht1xm88 442 40 infection infection NN cord-021413-1ht1xm88 442 41 , , , cord-021413-1ht1xm88 442 42 even even RB cord-021413-1ht1xm88 442 43 when when WRB cord-021413-1ht1xm88 442 44 the the DT cord-021413-1ht1xm88 442 45 mice mouse NNS cord-021413-1ht1xm88 442 46 are be VBP cord-021413-1ht1xm88 442 47 90 90 CD cord-021413-1ht1xm88 442 48 days day NNS cord-021413-1ht1xm88 442 49 old old JJ cord-021413-1ht1xm88 442 50 , , , cord-021413-1ht1xm88 442 51 whereas whereas IN cord-021413-1ht1xm88 442 52 the the DT cord-021413-1ht1xm88 442 53 A A NNP cord-021413-1ht1xm88 442 54 / / SYM cord-021413-1ht1xm88 442 55 J J NNP cord-021413-1ht1xm88 442 56 strain strain NN cord-021413-1ht1xm88 442 57 is be VBZ cord-021413-1ht1xm88 442 58 resistant resistant JJ cord-021413-1ht1xm88 442 59 , , , cord-021413-1ht1xm88 442 60 being be VBG cord-021413-1ht1xm88 442 61 susceptible susceptible JJ cord-021413-1ht1xm88 442 62 to to IN cord-021413-1ht1xm88 442 63 the the DT cord-021413-1ht1xm88 442 64 acute acute JJ cord-021413-1ht1xm88 442 65 disease disease NN cord-021413-1ht1xm88 442 66 only only RB cord-021413-1ht1xm88 442 67 up up IN cord-021413-1ht1xm88 442 68 to to TO cord-021413-1ht1xm88 442 69 3 3 CD cord-021413-1ht1xm88 442 70 - - SYM cord-021413-1ht1xm88 442 71 4 4 CD cord-021413-1ht1xm88 442 72 weeks week NNS cord-021413-1ht1xm88 442 73 of of IN cord-021413-1ht1xm88 442 74 age age NN cord-021413-1ht1xm88 442 75 . . . cord-021413-1ht1xm88 443 1 Although although IN cord-021413-1ht1xm88 443 2 C3H c3h JJ cord-021413-1ht1xm88 443 3 mice mouse NNS cord-021413-1ht1xm88 443 4 are be VBP cord-021413-1ht1xm88 443 5 partially partially RB cord-021413-1ht1xm88 443 6 susceptible susceptible JJ cord-021413-1ht1xm88 443 7 to to IN cord-021413-1ht1xm88 443 8 the the DT cord-021413-1ht1xm88 443 9 acute acute JJ cord-021413-1ht1xm88 443 10 phase phase NN cord-021413-1ht1xm88 443 11 of of IN cord-021413-1ht1xm88 443 12 the the DT cord-021413-1ht1xm88 443 13 disease disease NN cord-021413-1ht1xm88 443 14 , , , cord-021413-1ht1xm88 443 15 they -PRON- PRP cord-021413-1ht1xm88 443 16 are be VBP cord-021413-1ht1xm88 443 17 fully fully RB cord-021413-1ht1xm88 443 18 susceptible susceptible JJ cord-021413-1ht1xm88 443 19 to to IN cord-021413-1ht1xm88 443 20 the the DT cord-021413-1ht1xm88 443 21 chronic chronic JJ cord-021413-1ht1xm88 443 22 stage stage NN cord-021413-1ht1xm88 443 23 . . . cord-021413-1ht1xm88 444 1 In in IN cord-021413-1ht1xm88 444 2 nude nude JJ cord-021413-1ht1xm88 444 3 ( ( -LRB- cord-021413-1ht1xm88 444 4 nu nu NNP cord-021413-1ht1xm88 444 5 / / SYM cord-021413-1ht1xm88 444 6 nu nu NNP cord-021413-1ht1xm88 444 7 ) ) -RRB- cord-021413-1ht1xm88 444 8 mice mouse NNS cord-021413-1ht1xm88 444 9 , , , cord-021413-1ht1xm88 444 10 MHV MHV NNP cord-021413-1ht1xm88 444 11 takes take VBZ cord-021413-1ht1xm88 444 12 on on RP cord-021413-1ht1xm88 444 13 special special JJ cord-021413-1ht1xm88 444 14 significance significance NN cord-021413-1ht1xm88 444 15 . . . cord-021413-1ht1xm88 445 1 Indeed indeed RB cord-021413-1ht1xm88 445 2 , , , cord-021413-1ht1xm88 445 3 perhaps perhaps RB cord-021413-1ht1xm88 445 4 the the DT cord-021413-1ht1xm88 445 5 best good JJS cord-021413-1ht1xm88 445 6 description description NN cord-021413-1ht1xm88 445 7 of of IN cord-021413-1ht1xm88 445 8 the the DT cord-021413-1ht1xm88 445 9 clinical clinical JJ cord-021413-1ht1xm88 445 10 signs sign NNS cord-021413-1ht1xm88 445 11 may may MD cord-021413-1ht1xm88 445 12 be be VB cord-021413-1ht1xm88 445 13 found find VBN cord-021413-1ht1xm88 445 14 in in IN cord-021413-1ht1xm88 445 15 the the DT cord-021413-1ht1xm88 445 16 original original JJ cord-021413-1ht1xm88 445 17 report report NN cord-021413-1ht1xm88 445 18 describing describe VBG cord-021413-1ht1xm88 445 19 this this DT cord-021413-1ht1xm88 445 20 mutant mutant JJ cord-021413-1ht1xm88 445 21 mouse mouse NN cord-021413-1ht1xm88 445 22 ( ( -LRB- cord-021413-1ht1xm88 445 23 Flanagan Flanagan NNP cord-021413-1ht1xm88 445 24 , , , cord-021413-1ht1xm88 445 25 1966 1966 CD cord-021413-1ht1xm88 445 26 ) ) -RRB- cord-021413-1ht1xm88 445 27 , , , cord-021413-1ht1xm88 445 28 published publish VBN cord-021413-1ht1xm88 445 29 before before IN cord-021413-1ht1xm88 445 30 runt runt NN cord-021413-1ht1xm88 445 31 disease disease NN cord-021413-1ht1xm88 445 32 , , , cord-021413-1ht1xm88 445 33 as as IN cord-021413-1ht1xm88 445 34 the the DT cord-021413-1ht1xm88 445 35 wast wast NNP cord-021413-1ht1xm88 445 36 ing ing NNP cord-021413-1ht1xm88 445 37 syndrome syndrome NN cord-021413-1ht1xm88 445 38 was be VBD cord-021413-1ht1xm88 445 39 called call VBN cord-021413-1ht1xm88 445 40 , , , cord-021413-1ht1xm88 445 41 came come VBD cord-021413-1ht1xm88 445 42 to to TO cord-021413-1ht1xm88 445 43 be be VB cord-021413-1ht1xm88 445 44 recognized recognize VBN cord-021413-1ht1xm88 445 45 as as IN cord-021413-1ht1xm88 445 46 something something NN cord-021413-1ht1xm88 445 47 other other JJ cord-021413-1ht1xm88 445 48 than than IN cord-021413-1ht1xm88 445 49 a a DT cord-021413-1ht1xm88 445 50 genetic genetic JJ cord-021413-1ht1xm88 445 51 effect effect NN cord-021413-1ht1xm88 445 52 . . . cord-021413-1ht1xm88 446 1 MHV MHV NNP cord-021413-1ht1xm88 446 2 - - HYPH cord-021413-1ht1xm88 446 3 infected infect VBN cord-021413-1ht1xm88 446 4 nude nude JJ cord-021413-1ht1xm88 446 5 mice mouse NNS cord-021413-1ht1xm88 446 6 lose lose VBP cord-021413-1ht1xm88 446 7 weight weight NN cord-021413-1ht1xm88 446 8 slowly slowly RB cord-021413-1ht1xm88 446 9 or or CC cord-021413-1ht1xm88 446 10 rapidly rapidly RB cord-021413-1ht1xm88 446 11 . . . cord-021413-1ht1xm88 447 1 They -PRON- PRP cord-021413-1ht1xm88 447 2 move move VBP cord-021413-1ht1xm88 447 3 stiffly stiffly RB cord-021413-1ht1xm88 447 4 with with IN cord-021413-1ht1xm88 447 5 a a DT cord-021413-1ht1xm88 447 6 stilted stilted JJ cord-021413-1ht1xm88 447 7 gait gait NN cord-021413-1ht1xm88 447 8 , , , cord-021413-1ht1xm88 447 9 and and CC cord-021413-1ht1xm88 447 10 their -PRON- PRP$ cord-021413-1ht1xm88 447 11 faces face NNS cord-021413-1ht1xm88 447 12 assume assume VBP cord-021413-1ht1xm88 447 13 a a DT cord-021413-1ht1xm88 447 14 pointed pointed JJ cord-021413-1ht1xm88 447 15 , , , cord-021413-1ht1xm88 447 16 anxious anxious JJ cord-021413-1ht1xm88 447 17 appearance appearance NN cord-021413-1ht1xm88 447 18 . . . cord-021413-1ht1xm88 448 1 Partial partial JJ cord-021413-1ht1xm88 448 2 paralysis paralysis NN cord-021413-1ht1xm88 448 3 may may MD cord-021413-1ht1xm88 448 4 develop develop VB cord-021413-1ht1xm88 448 5 first first RB cord-021413-1ht1xm88 448 6 in in IN cord-021413-1ht1xm88 448 7 the the DT cord-021413-1ht1xm88 448 8 hindlimbs hindlimb NNS cord-021413-1ht1xm88 448 9 and and CC cord-021413-1ht1xm88 448 10 then then RB cord-021413-1ht1xm88 448 11 in in IN cord-021413-1ht1xm88 448 12 the the DT cord-021413-1ht1xm88 448 13 forelimbs forelimb NNS cord-021413-1ht1xm88 448 14 , , , cord-021413-1ht1xm88 448 15 resulting result VBG cord-021413-1ht1xm88 448 16 in in IN cord-021413-1ht1xm88 448 17 almost almost RB cord-021413-1ht1xm88 448 18 total total JJ cord-021413-1ht1xm88 448 19 immobility immobility NN cord-021413-1ht1xm88 448 20 . . . cord-021413-1ht1xm88 449 1 Nu/+ Nu/+ NNP cord-021413-1ht1xm88 449 2 heterozygotes heterozygote NNS cord-021413-1ht1xm88 449 3 are be VBP cord-021413-1ht1xm88 449 4 not not RB cord-021413-1ht1xm88 449 5 affected affect VBN cord-021413-1ht1xm88 449 6 in in IN cord-021413-1ht1xm88 449 7 this this DT cord-021413-1ht1xm88 449 8 way way NN cord-021413-1ht1xm88 449 9 . . . cord-021413-1ht1xm88 450 1 Flanagan Flanagan NNP cord-021413-1ht1xm88 450 2 ( ( -LRB- cord-021413-1ht1xm88 450 3 1966 1966 CD cord-021413-1ht1xm88 450 4 ) ) -RRB- cord-021413-1ht1xm88 450 5 found find VBD cord-021413-1ht1xm88 450 6 that that IN cord-021413-1ht1xm88 450 7 at at IN cord-021413-1ht1xm88 450 8 weaning weaning NN cord-021413-1ht1xm88 450 9 , , , cord-021413-1ht1xm88 450 10 the the DT cord-021413-1ht1xm88 450 11 nude nude JJ cord-021413-1ht1xm88 450 12 animals animal NNS cord-021413-1ht1xm88 450 13 were be VBD cord-021413-1ht1xm88 450 14 much much RB cord-021413-1ht1xm88 450 15 smaller small JJR cord-021413-1ht1xm88 450 16 than than IN cord-021413-1ht1xm88 450 17 controls control NNS cord-021413-1ht1xm88 450 18 ( ( -LRB- cord-021413-1ht1xm88 450 19 heterozygotes heterozygote NNS cord-021413-1ht1xm88 450 20 ) ) -RRB- cord-021413-1ht1xm88 450 21 , , , cord-021413-1ht1xm88 450 22 that that IN cord-021413-1ht1xm88 450 23 55 55 CD cord-021413-1ht1xm88 450 24 % % NN cord-021413-1ht1xm88 450 25 died die VBD cord-021413-1ht1xm88 450 26 within within IN cord-021413-1ht1xm88 450 27 2 2 CD cord-021413-1ht1xm88 450 28 weeks week NNS cord-021413-1ht1xm88 450 29 of of IN cord-021413-1ht1xm88 450 30 birth birth NN cord-021413-1ht1xm88 450 31 , , , cord-021413-1ht1xm88 450 32 and and CC cord-021413-1ht1xm88 450 33 that that IN cord-021413-1ht1xm88 450 34 100 100 CD cord-021413-1ht1xm88 450 35 % % NN cord-021413-1ht1xm88 450 36 were be VBD cord-021413-1ht1xm88 450 37 dead dead JJ cord-021413-1ht1xm88 450 38 by by IN cord-021413-1ht1xm88 450 39 25 25 CD cord-021413-1ht1xm88 450 40 weeks week NNS cord-021413-1ht1xm88 450 41 of of IN cord-021413-1ht1xm88 450 42 age age NN cord-021413-1ht1xm88 450 43 , , , cord-021413-1ht1xm88 450 44 whereas whereas IN cord-021413-1ht1xm88 450 45 only only RB cord-021413-1ht1xm88 450 46 6 6 CD cord-021413-1ht1xm88 450 47 % % NN cord-021413-1ht1xm88 450 48 of of IN cord-021413-1ht1xm88 450 49 controls control NNS cord-021413-1ht1xm88 450 50 died die VBD cord-021413-1ht1xm88 450 51 in in IN cord-021413-1ht1xm88 450 52 the the DT cord-021413-1ht1xm88 450 53 same same JJ cord-021413-1ht1xm88 450 54 period period NN cord-021413-1ht1xm88 450 55 . . . cord-021413-1ht1xm88 451 1 It -PRON- PRP cord-021413-1ht1xm88 451 2 was be VBD cord-021413-1ht1xm88 451 3 not not RB cord-021413-1ht1xm88 451 4 until until IN cord-021413-1ht1xm88 451 5 Sebesteny Sebesteny NNP cord-021413-1ht1xm88 451 6 and and CC cord-021413-1ht1xm88 451 7 Hill Hill NNP cord-021413-1ht1xm88 451 8 ( ( -LRB- cord-021413-1ht1xm88 451 9 1974 1974 CD cord-021413-1ht1xm88 451 10 ) ) -RRB- cord-021413-1ht1xm88 451 11 UV uv NN cord-021413-1ht1xm88 451 12 - - HYPH cord-021413-1ht1xm88 451 13 inactivated inactivate VBN cord-021413-1ht1xm88 451 14 virus virus NN cord-021413-1ht1xm88 451 15 did do VBD cord-021413-1ht1xm88 451 16 not not RB cord-021413-1ht1xm88 451 17 elicit elicit VB cord-021413-1ht1xm88 451 18 the the DT cord-021413-1ht1xm88 451 19 effect effect NN cord-021413-1ht1xm88 451 20 . . . cord-021413-1ht1xm88 452 1 The the DT cord-021413-1ht1xm88 452 2 authors author NNS cord-021413-1ht1xm88 452 3 be be VBP cord-021413-1ht1xm88 452 4 lieve lieve VBN cord-021413-1ht1xm88 452 5 that that IN cord-021413-1ht1xm88 452 6 fixed fix VBN cord-021413-1ht1xm88 452 7 macrophages macrophage NNS cord-021413-1ht1xm88 452 8 in in IN cord-021413-1ht1xm88 452 9 athymic athymic JJ cord-021413-1ht1xm88 452 10 mice mouse NNS cord-021413-1ht1xm88 452 11 may may MD cord-021413-1ht1xm88 452 12 be be VB cord-021413-1ht1xm88 452 13 acti acti NNP cord-021413-1ht1xm88 452 14 - - JJ cord-021413-1ht1xm88 452 15 vated vated JJ cord-021413-1ht1xm88 452 16 , , , cord-021413-1ht1xm88 452 17 as as IN cord-021413-1ht1xm88 452 18 was be VBD cord-021413-1ht1xm88 452 19 indicated indicate VBN cord-021413-1ht1xm88 452 20 by by IN cord-021413-1ht1xm88 452 21 Nickol Nickol NNP cord-021413-1ht1xm88 452 22 and and CC cord-021413-1ht1xm88 452 23 Bonventre Bonventre NNP cord-021413-1ht1xm88 452 24 ( ( -LRB- cord-021413-1ht1xm88 452 25 1977 1977 CD cord-021413-1ht1xm88 452 26 ) ) -RRB- cord-021413-1ht1xm88 452 27 and and CC cord-021413-1ht1xm88 452 28 by by IN cord-021413-1ht1xm88 452 29 Cheers Cheers NNPS cord-021413-1ht1xm88 452 30 and and CC cord-021413-1ht1xm88 452 31 Waller Waller NNP cord-021413-1ht1xm88 452 32 ( ( -LRB- cord-021413-1ht1xm88 452 33 1975 1975 CD cord-021413-1ht1xm88 452 34 ) ) -RRB- cord-021413-1ht1xm88 453 1 in in IN cord-021413-1ht1xm88 453 2 certain certain JJ cord-021413-1ht1xm88 453 3 bacterial bacterial JJ cord-021413-1ht1xm88 453 4 infections infection NNS cord-021413-1ht1xm88 453 5 in in IN cord-021413-1ht1xm88 453 6 nude nude JJ cord-021413-1ht1xm88 453 7 mice mouse NNS cord-021413-1ht1xm88 453 8 . . . cord-021413-1ht1xm88 454 1 T T NNP cord-021413-1ht1xm88 454 2 a a DT cord-021413-1ht1xm88 455 1 m m NNP cord-021413-1ht1xm88 455 2 u u NNP cord-021413-1ht1xm88 455 3 r r NNP cord-021413-1ht1xm88 455 4 a a FW cord-021413-1ht1xm88 455 5 et et FW cord-021413-1ht1xm88 455 6 aL aL NNP cord-021413-1ht1xm88 455 7 ( ( -LRB- cord-021413-1ht1xm88 455 8 1979 1979 CD cord-021413-1ht1xm88 455 9 ) ) -RRB- cord-021413-1ht1xm88 456 1 ( ( -LRB- cord-021413-1ht1xm88 456 2 see see VB cord-021413-1ht1xm88 456 3 , , , cord-021413-1ht1xm88 456 4 e e NN cord-021413-1ht1xm88 456 5 . . . cord-021413-1ht1xm88 457 1 g g NNP cord-021413-1ht1xm88 457 2 . . . cord-021413-1ht1xm88 457 3 , , , cord-021413-1ht1xm88 458 1 R r NN cord-021413-1ht1xm88 458 2 u u NN cord-021413-1ht1xm88 458 3 e e NN cord-021413-1ht1xm88 458 4 b b NN cord-021413-1ht1xm88 458 5 n n NN cord-021413-1ht1xm88 458 6 e e NN cord-021413-1ht1xm88 458 7 r r NN cord-021413-1ht1xm88 458 8 and and CC cord-021413-1ht1xm88 458 9 Bramhall Bramhall NNP cord-021413-1ht1xm88 458 10 , , , cord-021413-1ht1xm88 458 11 1960 1960 CD cord-021413-1ht1xm88 458 12 ; ; : cord-021413-1ht1xm88 458 13 Gledhill Gledhill NNP cord-021413-1ht1xm88 458 14 etal etal NNP cord-021413-1ht1xm88 458 15 . . . cord-021413-1ht1xm88 459 1 , , , cord-021413-1ht1xm88 459 2 1952 1952 CD cord-021413-1ht1xm88 459 3 ; ; : cord-021413-1ht1xm88 459 4 Nelson Nelson NNP cord-021413-1ht1xm88 459 5 , , , cord-021413-1ht1xm88 459 6 1953 1953 CD cord-021413-1ht1xm88 459 7 ) ) -RRB- cord-021413-1ht1xm88 459 8 . . . cord-021413-1ht1xm88 460 1 In in IN cord-021413-1ht1xm88 460 2 Liver liver NN cord-021413-1ht1xm88 460 3 regeneration regeneration NN cord-021413-1ht1xm88 460 4 m m NNP cord-021413-1ht1xm88 460 5 a a DT cord-021413-1ht1xm88 460 6 y y NN cord-021413-1ht1xm88 460 7 take take VBP cord-021413-1ht1xm88 460 8 place place NN cord-021413-1ht1xm88 460 9 as as RB cord-021413-1ht1xm88 460 10 early early RB cord-021413-1ht1xm88 460 11 as as IN cord-021413-1ht1xm88 460 12 1 1 CD cord-021413-1ht1xm88 460 13 0 0 CD cord-021413-1ht1xm88 460 14 -1 -1 NN cord-021413-1ht1xm88 460 15 4 4 CD cord-021413-1ht1xm88 460 16 days day NNS cord-021413-1ht1xm88 460 17 after after IN cord-021413-1ht1xm88 460 18 infection infection NN cord-021413-1ht1xm88 460 19 ( ( -LRB- cord-021413-1ht1xm88 460 20 Ruebner Ruebner NNP cord-021413-1ht1xm88 460 21 and and CC cord-021413-1ht1xm88 460 22 Bramhall Bramhall NNP cord-021413-1ht1xm88 460 23 , , , cord-021413-1ht1xm88 460 24 1960 1960 CD cord-021413-1ht1xm88 460 25 ) ) -RRB- cord-021413-1ht1xm88 460 26 , , , cord-021413-1ht1xm88 460 27 ranging range VBG cord-021413-1ht1xm88 460 28 from from IN cord-021413-1ht1xm88 460 29 complete complete JJ cord-021413-1ht1xm88 460 30 healing healing NN cord-021413-1ht1xm88 460 31 to to IN cord-021413-1ht1xm88 460 32 chronic chronic JJ cord-021413-1ht1xm88 460 33 scarring scarring NN cord-021413-1ht1xm88 460 34 with with IN cord-021413-1ht1xm88 460 35 intermediate intermediate JJ cord-021413-1ht1xm88 460 36 gradations gradation NNS cord-021413-1ht1xm88 460 37 . . . cord-021413-1ht1xm88 461 1 Kupffer Kupffer NNP cord-021413-1ht1xm88 461 2 cells cell NNS cord-021413-1ht1xm88 461 3 were be VBD cord-021413-1ht1xm88 461 4 examined examine VBN cord-021413-1ht1xm88 461 5 by by IN cord-021413-1ht1xm88 461 6 R r NN cord-021413-1ht1xm88 461 7 u u NN cord-021413-1ht1xm88 461 8 e e NN cord-021413-1ht1xm88 461 9 b b NN cord-021413-1ht1xm88 461 10 n n NN cord-021413-1ht1xm88 461 11 e e NN cord-021413-1ht1xm88 461 12 r r NN cord-021413-1ht1xm88 461 13 and and CC cord-021413-1ht1xm88 461 14 Miyai Miyai NNP cord-021413-1ht1xm88 461 15 ( ( -LRB- cord-021413-1ht1xm88 461 16 1962 1962 CD cord-021413-1ht1xm88 461 17 ) ) -RRB- cord-021413-1ht1xm88 461 18 and and CC cord-021413-1ht1xm88 461 19 R r NN cord-021413-1ht1xm88 461 20 u u NN cord-021413-1ht1xm88 461 21 e e NN cord-021413-1ht1xm88 461 22 b b NN cord-021413-1ht1xm88 461 23 n n NN cord-021413-1ht1xm88 461 24 e e NN cord-021413-1ht1xm88 461 25 r r NN cord-021413-1ht1xm88 461 26 et et NNP cord-021413-1ht1xm88 461 27 al al NNP cord-021413-1ht1xm88 461 28 . . . cord-021413-1ht1xm88 462 1 ( ( -LRB- cord-021413-1ht1xm88 462 2 1967 1967 CD cord-021413-1ht1xm88 462 3 ) ) -RRB- cord-021413-1ht1xm88 462 4 . . . cord-021413-1ht1xm88 463 1 T T NNP cord-021413-1ht1xm88 463 2 h h NN cord-021413-1ht1xm88 463 3 e e NN cord-021413-1ht1xm88 463 4 y y NNP cord-021413-1ht1xm88 463 5 m m NNP cord-021413-1ht1xm88 463 6 a a NNP cord-021413-1ht1xm88 463 7 y y NNP cord-021413-1ht1xm88 463 8 undergo undergo VB cord-021413-1ht1xm88 463 9 nuclear nuclear JJ cord-021413-1ht1xm88 463 10 pyknosis pyknosis NN cord-021413-1ht1xm88 463 11 and and CC cord-021413-1ht1xm88 463 12 karyorrhexis karyorrhexis NNP cord-021413-1ht1xm88 463 13 24 24 CD cord-021413-1ht1xm88 463 14 hr hr NN cord-021413-1ht1xm88 463 15 after after IN cord-021413-1ht1xm88 463 16 intravenous intravenous JJ cord-021413-1ht1xm88 463 17 inoculation inoculation NN cord-021413-1ht1xm88 463 18 of of IN cord-021413-1ht1xm88 463 19 M M NNP cord-021413-1ht1xm88 463 20 H h NN cord-021413-1ht1xm88 463 21 V v NN cord-021413-1ht1xm88 463 22 3 3 CD cord-021413-1ht1xm88 463 23 . . . cord-021413-1ht1xm88 464 1 In in IN cord-021413-1ht1xm88 464 2 infection infection NN cord-021413-1ht1xm88 464 3 with with IN cord-021413-1ht1xm88 464 4 neurotropic neurotropic NNP cord-021413-1ht1xm88 464 5 variants variant NNS cord-021413-1ht1xm88 464 6 , , , cord-021413-1ht1xm88 464 7 such such JJ cord-021413-1ht1xm88 464 8 as as IN cord-021413-1ht1xm88 464 9 J J NNP cord-021413-1ht1xm88 464 10 H H NNP cord-021413-1ht1xm88 464 11 M M NNP cord-021413-1ht1xm88 464 12 , , , cord-021413-1ht1xm88 464 13 the the DT cord-021413-1ht1xm88 464 14 principal principal JJ cord-021413-1ht1xm88 464 15 lesions lesion NNS cord-021413-1ht1xm88 464 16 appear appear VBP cord-021413-1ht1xm88 464 17 in in IN cord-021413-1ht1xm88 464 18 the the DT cord-021413-1ht1xm88 464 19 central central JJ cord-021413-1ht1xm88 464 20 nervous nervous JJ cord-021413-1ht1xm88 464 21 system system NN cord-021413-1ht1xm88 464 22 . . . cord-021413-1ht1xm88 465 1 Meningitis meningitis NN cord-021413-1ht1xm88 465 2 is be VBZ cord-021413-1ht1xm88 465 3 present present JJ cord-021413-1ht1xm88 465 4 but but CC cord-021413-1ht1xm88 465 5 varies vary VBZ cord-021413-1ht1xm88 465 6 in in IN cord-021413-1ht1xm88 465 7 degree degree NN cord-021413-1ht1xm88 465 8 and and CC cord-021413-1ht1xm88 465 9 loca loca NN cord-021413-1ht1xm88 465 10 tion tion NN cord-021413-1ht1xm88 465 11 . . . cord-021413-1ht1xm88 466 1 In in IN cord-021413-1ht1xm88 466 2 the the DT cord-021413-1ht1xm88 466 3 brain brain NN cord-021413-1ht1xm88 466 4 , , , cord-021413-1ht1xm88 466 5 lesions lesion NNS cord-021413-1ht1xm88 466 6 m m NNP cord-021413-1ht1xm88 466 7 a a DT cord-021413-1ht1xm88 466 8 y y NN cord-021413-1ht1xm88 466 9 be be VB cord-021413-1ht1xm88 466 10 found find VBN cord-021413-1ht1xm88 466 11 in in IN cord-021413-1ht1xm88 466 12 all all DT cord-021413-1ht1xm88 466 13 regions region NNS cord-021413-1ht1xm88 466 14 , , , cord-021413-1ht1xm88 466 15 but but CC cord-021413-1ht1xm88 466 16 the the DT cord-021413-1ht1xm88 466 17 hippocampus hippocampus NN cord-021413-1ht1xm88 466 18 and and CC cord-021413-1ht1xm88 466 19 its -PRON- PRP$ cord-021413-1ht1xm88 466 20 connections connection NNS cord-021413-1ht1xm88 466 21 , , , cord-021413-1ht1xm88 466 22 the the DT cord-021413-1ht1xm88 466 23 olfactory olfactory JJ cord-021413-1ht1xm88 466 24 lobes lobe NNS cord-021413-1ht1xm88 466 25 , , , cord-021413-1ht1xm88 466 26 the the DT cord-021413-1ht1xm88 466 27 periependymal periependymal JJ cord-021413-1ht1xm88 466 28 tissues tissue NNS cord-021413-1ht1xm88 466 29 , , , cord-021413-1ht1xm88 466 30 and and CC cord-021413-1ht1xm88 466 31 the the DT cord-021413-1ht1xm88 466 32 brain brain NN cord-021413-1ht1xm88 466 33 stem stem NN cord-021413-1ht1xm88 466 34 seem seem VBP cord-021413-1ht1xm88 466 35 to to TO cord-021413-1ht1xm88 466 36 b b NN cord-021413-1ht1xm88 466 37 e e LS cord-021413-1ht1xm88 466 38 affected affect VBD cord-021413-1ht1xm88 466 39 most most RBS cord-021413-1ht1xm88 466 40 often often RB cord-021413-1ht1xm88 466 41 . . . cord-021413-1ht1xm88 467 1 Necrotizing necrotize VBG cord-021413-1ht1xm88 467 2 lesions lesion NNS cord-021413-1ht1xm88 467 3 predominate predominate VBP cord-021413-1ht1xm88 467 4 in in IN cord-021413-1ht1xm88 467 5 the the DT cord-021413-1ht1xm88 467 6 olfactory olfactory JJ cord-021413-1ht1xm88 467 7 lobes lobe NNS cord-021413-1ht1xm88 467 8 and and CC cord-021413-1ht1xm88 467 9 hippocampal hippocampal JJ cord-021413-1ht1xm88 467 10 regions region NNS cord-021413-1ht1xm88 467 11 , , , cord-021413-1ht1xm88 467 12 whereas whereas IN cord-021413-1ht1xm88 467 13 demyelination demyelination NN cord-021413-1ht1xm88 467 14 is be VBZ cord-021413-1ht1xm88 467 15 the the DT cord-021413-1ht1xm88 467 16 major major JJ cord-021413-1ht1xm88 467 17 change change NN cord-021413-1ht1xm88 467 18 in in IN cord-021413-1ht1xm88 467 19 the the DT cord-021413-1ht1xm88 467 20 brain brain NN cord-021413-1ht1xm88 467 21 stem stem NN cord-021413-1ht1xm88 467 22 . . . cord-021413-1ht1xm88 468 1 S s NN cord-021413-1ht1xm88 468 2 o o NN cord-021413-1ht1xm88 468 3 m m NN cord-021413-1ht1xm88 468 4 e e NN cord-021413-1ht1xm88 468 5 exudate exudate NN cord-021413-1ht1xm88 468 6 m m CD cord-021413-1ht1xm88 469 1 a a DT cord-021413-1ht1xm88 469 2 y y NN cord-021413-1ht1xm88 469 3 be be VB cord-021413-1ht1xm88 469 4 found find VBN cord-021413-1ht1xm88 469 5 around around IN cord-021413-1ht1xm88 469 6 blood blood NN cord-021413-1ht1xm88 469 7 vessels vessel NNS cord-021413-1ht1xm88 469 8 associated associate VBN cord-021413-1ht1xm88 469 9 with with IN cord-021413-1ht1xm88 469 10 lesions lesion NNS cord-021413-1ht1xm88 469 11 , , , cord-021413-1ht1xm88 469 12 and and CC cord-021413-1ht1xm88 469 13 at at IN cord-021413-1ht1xm88 469 14 about about RB cord-021413-1ht1xm88 469 15 5 5 CD cord-021413-1ht1xm88 469 16 days day NNS cord-021413-1ht1xm88 469 17 after after IN cord-021413-1ht1xm88 469 18 infection infection NN cord-021413-1ht1xm88 469 19 , , , cord-021413-1ht1xm88 469 20 proliferating proliferate VBG cord-021413-1ht1xm88 469 21 pericytes pericyte NNS cord-021413-1ht1xm88 469 22 and and CC cord-021413-1ht1xm88 469 23 scant scant JJ cord-021413-1ht1xm88 469 24 lym lym NNP cord-021413-1ht1xm88 469 25 phocytic phocytic JJ cord-021413-1ht1xm88 469 26 cuffing cuffing NN cord-021413-1ht1xm88 469 27 can can MD cord-021413-1ht1xm88 469 28 be be VB cord-021413-1ht1xm88 469 29 seen see VBN cord-021413-1ht1xm88 469 30 . . . cord-021413-1ht1xm88 470 1 Peripheral peripheral JJ cord-021413-1ht1xm88 470 2 nerves nerve NNS cord-021413-1ht1xm88 470 3 show show VBP cord-021413-1ht1xm88 470 4 n n NN cord-021413-1ht1xm88 470 5 o o NN cord-021413-1ht1xm88 470 6 change change NN cord-021413-1ht1xm88 470 7 . . . cord-021413-1ht1xm88 471 1 In in IN cord-021413-1ht1xm88 471 2 sucklings suckling NNS cord-021413-1ht1xm88 471 3 , , , cord-021413-1ht1xm88 471 4 J J NNP cord-021413-1ht1xm88 471 5 H H NNP cord-021413-1ht1xm88 471 6 M M NNP cord-021413-1ht1xm88 471 7 virus virus NN cord-021413-1ht1xm88 471 8 produces produce VBZ cord-021413-1ht1xm88 471 9 extensive extensive JJ cord-021413-1ht1xm88 471 10 lesions lesion NNS cord-021413-1ht1xm88 471 11 in in IN cord-021413-1ht1xm88 471 12 the the DT cord-021413-1ht1xm88 471 13 brain brain NN cord-021413-1ht1xm88 471 14 and and CC cord-021413-1ht1xm88 471 15 cord cord NN cord-021413-1ht1xm88 471 16 at at IN cord-021413-1ht1xm88 471 17 6 6 CD cord-021413-1ht1xm88 471 18 -8 -8 CD cord-021413-1ht1xm88 471 19 days day NNS cord-021413-1ht1xm88 471 20 . . . cord-021413-1ht1xm88 472 1 Meningitis meningitis NN cord-021413-1ht1xm88 472 2 is be VBZ cord-021413-1ht1xm88 472 3 present present JJ cord-021413-1ht1xm88 472 4 , , , cord-021413-1ht1xm88 472 5 and and CC cord-021413-1ht1xm88 472 6 large large JJ cord-021413-1ht1xm88 472 7 regions region NNS cord-021413-1ht1xm88 472 8 of of IN cord-021413-1ht1xm88 472 9 necrosis necrosis NN cord-021413-1ht1xm88 472 10 with with IN cord-021413-1ht1xm88 472 11 m m NNP cord-021413-1ht1xm88 472 12 a a NNP cord-021413-1ht1xm88 472 13 n n NNP cord-021413-1ht1xm88 472 14 y y NNP cord-021413-1ht1xm88 472 15 giant giant NN cord-021413-1ht1xm88 472 16 cells cell NNS cord-021413-1ht1xm88 472 17 occur occur VBP cord-021413-1ht1xm88 472 18 throughout throughout IN cord-021413-1ht1xm88 472 19 the the DT cord-021413-1ht1xm88 472 20 brain brain NN cord-021413-1ht1xm88 472 21 . . . cord-021413-1ht1xm88 473 1 In in IN cord-021413-1ht1xm88 473 2 the the DT cord-021413-1ht1xm88 473 3 cord cord NN cord-021413-1ht1xm88 473 4 , , , cord-021413-1ht1xm88 473 5 the the DT cord-021413-1ht1xm88 473 6 lesions lesion NNS cord-021413-1ht1xm88 473 7 consist consist VBP cord-021413-1ht1xm88 473 8 of of IN cord-021413-1ht1xm88 473 9 spongy spongy JJ cord-021413-1ht1xm88 473 10 necrosis necrosis NN cord-021413-1ht1xm88 473 11 of of IN cord-021413-1ht1xm88 473 12 the the DT cord-021413-1ht1xm88 473 13 central central JJ cord-021413-1ht1xm88 473 14 gray gray JJ cord-021413-1ht1xm88 473 15 matter matter NN cord-021413-1ht1xm88 473 16 . . . cord-021413-1ht1xm88 474 1 Ganglion ganglion NN cord-021413-1ht1xm88 474 2 cells cell NNS cord-021413-1ht1xm88 474 3 appear appear VBP cord-021413-1ht1xm88 474 4 unaffected unaffected JJ cord-021413-1ht1xm88 474 5 . . . cord-021413-1ht1xm88 475 1 Powell Powell NNP cord-021413-1ht1xm88 475 2 and and CC cord-021413-1ht1xm88 475 3 Lampert Lampert NNP cord-021413-1ht1xm88 475 4 ( ( -LRB- cord-021413-1ht1xm88 475 5 1975 1975 CD cord-021413-1ht1xm88 475 6 ) ) -RRB- cord-021413-1ht1xm88 475 7 resolved resolve VBN cord-021413-1ht1xm88 475 8 into into IN cord-021413-1ht1xm88 475 9 small small JJ cord-021413-1ht1xm88 475 10 foci focus NNS cord-021413-1ht1xm88 475 11 of of IN cord-021413-1ht1xm88 475 12 fibrillary fibrillary NNP cord-021413-1ht1xm88 475 13 gliosis gliosis NNP cord-021413-1ht1xm88 475 14 with with IN cord-021413-1ht1xm88 475 15 an an DT cord-021413-1ht1xm88 475 16 increased increase VBN cord-021413-1ht1xm88 475 17 size size NN cord-021413-1ht1xm88 475 18 and and CC cord-021413-1ht1xm88 475 19 n n NN cord-021413-1ht1xm88 475 20 u u NN cord-021413-1ht1xm88 475 21 m m NN cord-021413-1ht1xm88 475 22 b b NN cord-021413-1ht1xm88 475 23 e e NN cord-021413-1ht1xm88 475 24 r r NN cord-021413-1ht1xm88 475 25 of of IN cord-021413-1ht1xm88 475 26 astrocytic astrocytic JJ cord-021413-1ht1xm88 475 27 processes process NNS cord-021413-1ht1xm88 475 28 . . . cord-021413-1ht1xm88 476 1 T T NNP cord-021413-1ht1xm88 476 2 h h NN cord-021413-1ht1xm88 476 3 e e NN cord-021413-1ht1xm88 476 4 importance importance NN cord-021413-1ht1xm88 476 5 of of IN cord-021413-1ht1xm88 476 6 this this DT cord-021413-1ht1xm88 476 7 finding finding NN cord-021413-1ht1xm88 476 8 for for IN cord-021413-1ht1xm88 476 9 investigations investigation NNS cord-021413-1ht1xm88 476 10 into into IN cord-021413-1ht1xm88 476 11 the the DT cord-021413-1ht1xm88 476 12 cause cause NN cord-021413-1ht1xm88 476 13 of of IN cord-021413-1ht1xm88 476 14 multiple multiple JJ cord-021413-1ht1xm88 476 15 sclerosis sclerosis NN cord-021413-1ht1xm88 476 16 and and CC cord-021413-1ht1xm88 476 17 other other JJ cord-021413-1ht1xm88 476 18 demyelinating demyelinate VBG cord-021413-1ht1xm88 476 19 diseases disease NNS cord-021413-1ht1xm88 476 20 in in IN cord-021413-1ht1xm88 476 21 m m NNP cord-021413-1ht1xm88 476 22 a a NNP cord-021413-1ht1xm88 476 23 n n NN cord-021413-1ht1xm88 476 24 is be VBZ cord-021413-1ht1xm88 476 25 obvious obvious JJ cord-021413-1ht1xm88 476 26 and and CC cord-021413-1ht1xm88 476 27 has have VBZ cord-021413-1ht1xm88 476 28 been be VBN cord-021413-1ht1xm88 476 29 addressed address VBN cord-021413-1ht1xm88 476 30 b b NNP cord-021413-1ht1xm88 476 31 y y NNP cord-021413-1ht1xm88 476 32 , , , cord-021413-1ht1xm88 476 33 a a DT cord-021413-1ht1xm88 476 34 m m NN cord-021413-1ht1xm88 476 35 o o NN cord-021413-1ht1xm88 476 36 n n NN cord-021413-1ht1xm88 476 37 g g NNP cord-021413-1ht1xm88 476 38 others other NNS cord-021413-1ht1xm88 476 39 , , , cord-021413-1ht1xm88 476 40 Lucas Lucas NNP cord-021413-1ht1xm88 476 41 et et NNP cord-021413-1ht1xm88 476 42 al al NNP cord-021413-1ht1xm88 476 43 . . . cord-021413-1ht1xm88 477 1 ( ( -LRB- cord-021413-1ht1xm88 477 2 1977 1977 CD cord-021413-1ht1xm88 477 3 ) ) -RRB- cord-021413-1ht1xm88 478 1 and and CC cord-021413-1ht1xm88 478 2 Lampert Lampert NNP cord-021413-1ht1xm88 478 3 ( ( -LRB- cord-021413-1ht1xm88 478 4 1978 1978 CD cord-021413-1ht1xm88 478 5 ) ) -RRB- cord-021413-1ht1xm88 478 6 . . . cord-021413-1ht1xm88 479 1 In in IN cord-021413-1ht1xm88 479 2 sucklings suckling NNS cord-021413-1ht1xm88 479 3 infected infect VBN cord-021413-1ht1xm88 479 4 with with IN cord-021413-1ht1xm88 479 5 enterotropic enterotropic NNP cord-021413-1ht1xm88 479 6 strains strain NNS cord-021413-1ht1xm88 479 7 ( ( -LRB- cord-021413-1ht1xm88 479 8 Kraft Kraft NNP cord-021413-1ht1xm88 479 9 , , , cord-021413-1ht1xm88 479 10 1962a 1962a CD cord-021413-1ht1xm88 479 11 ; ; : cord-021413-1ht1xm88 479 12 Broderson Broderson NNP cord-021413-1ht1xm88 479 13 et et NNP cord-021413-1ht1xm88 479 14 al al NNP cord-021413-1ht1xm88 479 15 . . NNP cord-021413-1ht1xm88 479 16 , , , cord-021413-1ht1xm88 479 17 1976 1976 CD cord-021413-1ht1xm88 479 18 ; ; : cord-021413-1ht1xm88 479 19 Ishida Ishida NNP cord-021413-1ht1xm88 479 20 et et NNP cord-021413-1ht1xm88 479 21 al al NNP cord-021413-1ht1xm88 479 22 . . NNP cord-021413-1ht1xm88 479 23 , , , cord-021413-1ht1xm88 479 24 1978 1978 CD cord-021413-1ht1xm88 479 25 ; ; : cord-021413-1ht1xm88 479 26 Ishida Ishida NNP cord-021413-1ht1xm88 479 27 and and CC cord-021413-1ht1xm88 479 28 Fuji Fuji NNP cord-021413-1ht1xm88 479 29 wara wara NNP cord-021413-1ht1xm88 479 30 , , , cord-021413-1ht1xm88 479 31 1979 1979 CD cord-021413-1ht1xm88 479 32 ; ; : cord-021413-1ht1xm88 479 33 R R NNP cord-021413-1ht1xm88 479 34 o o NN cord-021413-1ht1xm88 479 35 w w NN cord-021413-1ht1xm88 479 36 e e NN cord-021413-1ht1xm88 479 37 et et NNP cord-021413-1ht1xm88 479 38 al al NNP cord-021413-1ht1xm88 479 39 . . NNP cord-021413-1ht1xm88 479 40 , , , cord-021413-1ht1xm88 479 41 1963 1963 CD cord-021413-1ht1xm88 479 42 ; ; : cord-021413-1ht1xm88 479 43 Hierholzer Hierholzer NNP cord-021413-1ht1xm88 479 44 et et NNP cord-021413-1ht1xm88 479 45 al al NNP cord-021413-1ht1xm88 479 46 . . NNP cord-021413-1ht1xm88 479 47 , , , cord-021413-1ht1xm88 479 48 1979 1979 CD cord-021413-1ht1xm88 479 49 ) ) -RRB- cord-021413-1ht1xm88 479 50 Strains strain NNS cord-021413-1ht1xm88 479 51 ( ( -LRB- cord-021413-1ht1xm88 479 52 Dick Dick NNP cord-021413-1ht1xm88 479 53 et et FW cord-021413-1ht1xm88 479 54 al al NNP cord-021413-1ht1xm88 479 55 . . NNP cord-021413-1ht1xm88 479 56 , , , cord-021413-1ht1xm88 479 57 1956 1956 CD cord-021413-1ht1xm88 479 58 ; ; : cord-021413-1ht1xm88 479 59 R r NN cord-021413-1ht1xm88 479 60 u u NN cord-021413-1ht1xm88 479 61 e e NN cord-021413-1ht1xm88 479 62 b b NN cord-021413-1ht1xm88 479 63 n n NN cord-021413-1ht1xm88 479 64 e e NN cord-021413-1ht1xm88 479 65 r r NN cord-021413-1ht1xm88 479 66 and and CC cord-021413-1ht1xm88 479 67 Bramhall Bramhall NNP cord-021413-1ht1xm88 479 68 , , , cord-021413-1ht1xm88 479 69 1960 1960 CD cord-021413-1ht1xm88 479 70 ; ; : cord-021413-1ht1xm88 479 71 Hirano Hirano NNP cord-021413-1ht1xm88 479 72 and and CC cord-021413-1ht1xm88 479 73 Ruebner Ruebner NNP cord-021413-1ht1xm88 479 74 , , , cord-021413-1ht1xm88 479 75 1966 1966 CD cord-021413-1ht1xm88 479 76 ) ) -RRB- cord-021413-1ht1xm88 479 77 , , , cord-021413-1ht1xm88 479 78 and and CC cord-021413-1ht1xm88 479 79 Biggart Biggart NNP cord-021413-1ht1xm88 479 80 and and CC cord-021413-1ht1xm88 479 81 Ruebner Ruebner NNP cord-021413-1ht1xm88 479 82 ( ( -LRB- cord-021413-1ht1xm88 479 83 1970 1970 CD cord-021413-1ht1xm88 479 84 ) ) -RRB- cord-021413-1ht1xm88 479 85 attribute attribute VB cord-021413-1ht1xm88 479 86 the the DT cord-021413-1ht1xm88 479 87 change change NN cord-021413-1ht1xm88 479 88 to to IN cord-021413-1ht1xm88 479 89 virus virus NN cord-021413-1ht1xm88 479 90 replication replication NN cord-021413-1ht1xm88 479 91 in in IN cord-021413-1ht1xm88 479 92 lymphocytes lymphocyte NNS cord-021413-1ht1xm88 479 93 . . . cord-021413-1ht1xm88 480 1 In in IN cord-021413-1ht1xm88 480 2 other other JJ cord-021413-1ht1xm88 480 3 organs organ NNS cord-021413-1ht1xm88 480 4 , , , cord-021413-1ht1xm88 480 5 minute minute VBD cord-021413-1ht1xm88 480 6 superficial superficial JJ cord-021413-1ht1xm88 480 7 necrotic necrotic JJ cord-021413-1ht1xm88 480 8 foci foci NN cord-021413-1ht1xm88 480 9 m m NN cord-021413-1ht1xm88 480 10 a a DT cord-021413-1ht1xm88 480 11 y y NN cord-021413-1ht1xm88 480 12 be be VB cord-021413-1ht1xm88 480 13 found find VBN cord-021413-1ht1xm88 480 14 in in IN cord-021413-1ht1xm88 480 15 the the DT cord-021413-1ht1xm88 480 16 stomach stomach NN cord-021413-1ht1xm88 480 17 . . . cord-021413-1ht1xm88 481 1 N n NN cord-021413-1ht1xm88 481 2 o o NN cord-021413-1ht1xm88 481 3 changes change NNS cord-021413-1ht1xm88 481 4 are be VBP cord-021413-1ht1xm88 481 5 seen see VBN cord-021413-1ht1xm88 481 6 in in IN cord-021413-1ht1xm88 481 7 the the DT cord-021413-1ht1xm88 481 8 heart heart NN cord-021413-1ht1xm88 481 9 , , , cord-021413-1ht1xm88 481 10 lungs lung NNS cord-021413-1ht1xm88 481 11 , , , cord-021413-1ht1xm88 481 12 pancreas pancrea NNS cord-021413-1ht1xm88 481 13 , , , cord-021413-1ht1xm88 481 14 kidney kidney NN cord-021413-1ht1xm88 481 15 , , , cord-021413-1ht1xm88 481 16 adrenals adrenal NNS cord-021413-1ht1xm88 481 17 , , , cord-021413-1ht1xm88 481 18 voluntary voluntary JJ cord-021413-1ht1xm88 481 19 m m NNP cord-021413-1ht1xm88 481 20 u u NNP cord-021413-1ht1xm88 481 21 s s NNP cord-021413-1ht1xm88 481 22 c c NN cord-021413-1ht1xm88 481 23 l l NN cord-021413-1ht1xm88 481 24 e e NNP cord-021413-1ht1xm88 481 25 , , , cord-021413-1ht1xm88 481 26 femoral femoral JJ cord-021413-1ht1xm88 481 27 o o NN cord-021413-1ht1xm88 481 28 r r NN cord-021413-1ht1xm88 481 29 ver ver NNP cord-021413-1ht1xm88 481 30 tebral tebral NNP cord-021413-1ht1xm88 481 31 bone bone NNP cord-021413-1ht1xm88 481 32 m m NNP cord-021413-1ht1xm88 481 33 a a DT cord-021413-1ht1xm88 481 34 r r NN cord-021413-1ht1xm88 481 35 r r NN cord-021413-1ht1xm88 481 36 o o NN cord-021413-1ht1xm88 481 37 w w NN cord-021413-1ht1xm88 481 38 , , , cord-021413-1ht1xm88 481 39 or or CC cord-021413-1ht1xm88 481 40 pituitary pituitary JJ cord-021413-1ht1xm88 481 41 gland gland NN cord-021413-1ht1xm88 481 42 , , , cord-021413-1ht1xm88 481 43 although although IN cord-021413-1ht1xm88 481 44 virus virus NN cord-021413-1ht1xm88 481 45 m m NNP cord-021413-1ht1xm88 481 46 a a NNP cord-021413-1ht1xm88 481 47 y y NN cord-021413-1ht1xm88 481 48 be be VB cord-021413-1ht1xm88 481 49 isolated isolate VBN cord-021413-1ht1xm88 481 50 from from IN cord-021413-1ht1xm88 481 51 some some DT cord-021413-1ht1xm88 481 52 of of IN cord-021413-1ht1xm88 481 53 those those DT cord-021413-1ht1xm88 481 54 organs organ NNS cord-021413-1ht1xm88 481 55 . . . cord-021413-1ht1xm88 482 1 Occasional occasional JJ cord-021413-1ht1xm88 482 2 giant giant JJ cord-021413-1ht1xm88 482 3 cells cell NNS cord-021413-1ht1xm88 482 4 are be VBP cord-021413-1ht1xm88 482 5 found find VBN cord-021413-1ht1xm88 482 6 in in IN cord-021413-1ht1xm88 482 7 peripancreatic peripancreatic JJ cord-021413-1ht1xm88 482 8 lymph lymph NN cord-021413-1ht1xm88 482 9 nodes node NNS cord-021413-1ht1xm88 482 10 and and CC cord-021413-1ht1xm88 482 11 in in IN cord-021413-1ht1xm88 482 12 P p NN cord-021413-1ht1xm88 482 13 e e NN cord-021413-1ht1xm88 482 14 y y NN cord-021413-1ht1xm88 482 15 e e NN cord-021413-1ht1xm88 482 16 r r NNP cord-021413-1ht1xm88 482 17 ' ' '' cord-021413-1ht1xm88 482 18 s s POS cord-021413-1ht1xm88 482 19 patches patch NNS cord-021413-1ht1xm88 482 20 . . . cord-021413-1ht1xm88 483 1 Flanagan Flanagan NNP cord-021413-1ht1xm88 483 2 ( ( -LRB- cord-021413-1ht1xm88 483 3 1966 1966 CD cord-021413-1ht1xm88 483 4 ) ) -RRB- cord-021413-1ht1xm88 483 5 islands island NNS cord-021413-1ht1xm88 483 6 of of IN cord-021413-1ht1xm88 483 7 hepatocytes hepatocyte NNS cord-021413-1ht1xm88 483 8 , , , cord-021413-1ht1xm88 483 9 markedly markedly RB cord-021413-1ht1xm88 483 10 hypertrophied hypertrophied JJ cord-021413-1ht1xm88 483 11 , , , cord-021413-1ht1xm88 483 12 remained remain VBD cord-021413-1ht1xm88 483 13 . . . cord-021413-1ht1xm88 484 1 Changes change NNS cord-021413-1ht1xm88 484 2 in in IN cord-021413-1ht1xm88 484 3 other other JJ cord-021413-1ht1xm88 484 4 organs organ NNS cord-021413-1ht1xm88 484 5 were be VBD cord-021413-1ht1xm88 484 6 not not RB cord-021413-1ht1xm88 484 7 described describe VBN cord-021413-1ht1xm88 484 8 . . . cord-021413-1ht1xm88 485 1 The the DT cord-021413-1ht1xm88 485 2 liver liver NN cord-021413-1ht1xm88 485 3 lesions lesion NNS cord-021413-1ht1xm88 485 4 observed observe VBN cord-021413-1ht1xm88 485 5 in in IN cord-021413-1ht1xm88 485 6 other other JJ cord-021413-1ht1xm88 485 7 nude nude JJ cord-021413-1ht1xm88 485 8 mice mouse NNS cord-021413-1ht1xm88 485 9 infected infect VBN cord-021413-1ht1xm88 485 10 with with IN cord-021413-1ht1xm88 485 11 MHV MHV NNP cord-021413-1ht1xm88 485 12 were be VBD cord-021413-1ht1xm88 485 13 similar similar JJ cord-021413-1ht1xm88 485 14 . . . cord-021413-1ht1xm88 486 1 Sebesteny Sebesteny NNP cord-021413-1ht1xm88 486 2 and and CC cord-021413-1ht1xm88 486 3 Hill Hill NNP cord-021413-1ht1xm88 486 4 ( ( -LRB- cord-021413-1ht1xm88 486 5 1974 1974 CD cord-021413-1ht1xm88 486 6 ) ) -RRB- cord-021413-1ht1xm88 486 7 noted note VBD cord-021413-1ht1xm88 486 8 central central JJ cord-021413-1ht1xm88 486 9 nervous nervous JJ cord-021413-1ht1xm88 486 10 system system NN cord-021413-1ht1xm88 486 11 lesions lesion NNS cord-021413-1ht1xm88 486 12 in in IN cord-021413-1ht1xm88 486 13 their -PRON- PRP$ cord-021413-1ht1xm88 486 14 nude nude JJ cord-021413-1ht1xm88 486 15 mice mouse NNS cord-021413-1ht1xm88 486 16 . . . cord-021413-1ht1xm88 487 1 Ward Ward NNP cord-021413-1ht1xm88 487 2 et et NNP cord-021413-1ht1xm88 487 3 al al NNP cord-021413-1ht1xm88 487 4 . . . cord-021413-1ht1xm88 488 1 ( ( -LRB- cord-021413-1ht1xm88 488 2 1977 1977 CD cord-021413-1ht1xm88 488 3 ) ) -RRB- cord-021413-1ht1xm88 488 4 also also RB cord-021413-1ht1xm88 488 5 encountered encounter VBD cord-021413-1ht1xm88 488 6 central central JJ cord-021413-1ht1xm88 488 7 nervous nervous JJ cord-021413-1ht1xm88 488 8 system system NN cord-021413-1ht1xm88 488 9 lesions lesion NNS cord-021413-1ht1xm88 488 10 in in IN cord-021413-1ht1xm88 488 11 addition addition NN cord-021413-1ht1xm88 488 12 to to IN cord-021413-1ht1xm88 488 13 vascular vascular JJ cord-021413-1ht1xm88 488 14 changes change NNS cord-021413-1ht1xm88 488 15 , , , cord-021413-1ht1xm88 488 16 giant giant JJ cord-021413-1ht1xm88 488 17 cell cell NN cord-021413-1ht1xm88 488 18 peritonitis peritonitis NN cord-021413-1ht1xm88 488 19 , , , cord-021413-1ht1xm88 488 20 ascites ascites NN cord-021413-1ht1xm88 488 21 , , , cord-021413-1ht1xm88 488 22 and and CC cord-021413-1ht1xm88 488 23 giant giant JJ cord-021413-1ht1xm88 488 24 cells cell NNS cord-021413-1ht1xm88 488 25 in in IN cord-021413-1ht1xm88 488 26 the the DT cord-021413-1ht1xm88 488 27 villous villous JJ cord-021413-1ht1xm88 488 28 epithelium epithelium NN cord-021413-1ht1xm88 488 29 of of IN cord-021413-1ht1xm88 488 30 the the DT cord-021413-1ht1xm88 488 31 intestines intestine NNS cord-021413-1ht1xm88 488 32 . . . cord-021413-1ht1xm88 489 1 Since since IN cord-021413-1ht1xm88 489 2 virus virus NN cord-021413-1ht1xm88 489 3 can can MD cord-021413-1ht1xm88 489 4 be be VB cord-021413-1ht1xm88 489 5 transmitted transmit VBN cord-021413-1ht1xm88 489 6 perorally perorally RB cord-021413-1ht1xm88 489 7 and and CC cord-021413-1ht1xm88 489 8 intranasally intranasally RB cord-021413-1ht1xm88 489 9 , , , cord-021413-1ht1xm88 489 10 it -PRON- PRP cord-021413-1ht1xm88 489 11 may may MD cord-021413-1ht1xm88 489 12 be be VB cord-021413-1ht1xm88 489 13 assumed assume VBN cord-021413-1ht1xm88 489 14 that that IN cord-021413-1ht1xm88 489 15 these these DT cord-021413-1ht1xm88 489 16 are be VBP cord-021413-1ht1xm88 489 17 the the DT cord-021413-1ht1xm88 489 18 principal principal JJ cord-021413-1ht1xm88 489 19 routes route NNS cord-021413-1ht1xm88 489 20 of of IN cord-021413-1ht1xm88 489 21 natural natural JJ cord-021413-1ht1xm88 489 22 infection infection NN cord-021413-1ht1xm88 489 23 . . . cord-021413-1ht1xm88 490 1 Transmission transmission NN cord-021413-1ht1xm88 490 2 may may MD cord-021413-1ht1xm88 490 3 be be VB cord-021413-1ht1xm88 490 4 mediated mediate VBN cord-021413-1ht1xm88 490 5 by by IN cord-021413-1ht1xm88 490 6 both both CC cord-021413-1ht1xm88 490 7 the the DT cord-021413-1ht1xm88 490 8 airborne airborne JJ cord-021413-1ht1xm88 490 9 and and CC cord-021413-1ht1xm88 490 10 contact contact NN cord-021413-1ht1xm88 490 11 modes mode NNS cord-021413-1ht1xm88 490 12 . . . cord-021413-1ht1xm88 491 1 Feces fece NNS cord-021413-1ht1xm88 491 2 , , , cord-021413-1ht1xm88 491 3 nasopharyngeal nasopharyngeal JJ cord-021413-1ht1xm88 491 4 exudates exudate NNS cord-021413-1ht1xm88 491 5 , , , cord-021413-1ht1xm88 491 6 and and CC cord-021413-1ht1xm88 491 7 perhaps perhaps RB cord-021413-1ht1xm88 491 8 urine urine NN cord-021413-1ht1xm88 491 9 would would MD cord-021413-1ht1xm88 491 10 be be VB cord-021413-1ht1xm88 491 11 sources source NNS cord-021413-1ht1xm88 491 12 of of IN cord-021413-1ht1xm88 491 13 infection infection NN cord-021413-1ht1xm88 491 14 . . . cord-021413-1ht1xm88 492 1 Evidence evidence NN cord-021413-1ht1xm88 492 2 of of IN cord-021413-1ht1xm88 492 3 vertical vertical JJ cord-021413-1ht1xm88 492 4 transmission transmission NN cord-021413-1ht1xm88 492 5 is be VBZ cord-021413-1ht1xm88 492 6 at at IN cord-021413-1ht1xm88 492 7 hand hand NN cord-021413-1ht1xm88 492 8 , , , cord-021413-1ht1xm88 492 9 but but CC cord-021413-1ht1xm88 492 10 reports report NNS cord-021413-1ht1xm88 492 11 are be VBP cord-021413-1ht1xm88 492 12 conflicting conflict VBG cord-021413-1ht1xm88 492 13 . . . cord-021413-1ht1xm88 493 1 Piccinino Piccinino NNP cord-021413-1ht1xm88 493 2 et et FW cord-021413-1ht1xm88 493 3 al al NNP cord-021413-1ht1xm88 493 4 . . . cord-021413-1ht1xm88 494 1 ( ( -LRB- cord-021413-1ht1xm88 494 2 1966 1966 CD cord-021413-1ht1xm88 494 3 ) ) -RRB- cord-021413-1ht1xm88 494 4 with with IN cord-021413-1ht1xm88 494 5 or or CC cord-021413-1ht1xm88 494 6 without without IN cord-021413-1ht1xm88 494 7 booster booster NN cord-021413-1ht1xm88 494 8 , , , cord-021413-1ht1xm88 494 9 showed show VBD cord-021413-1ht1xm88 494 10 no no DT cord-021413-1ht1xm88 494 11 antibody antibody NN cord-021413-1ht1xm88 494 12 in in IN cord-021413-1ht1xm88 494 13 the the DT cord-021413-1ht1xm88 494 14 same same JJ cord-021413-1ht1xm88 494 15 colony colony NN cord-021413-1ht1xm88 494 16 . . . cord-021413-1ht1xm88 495 1 In in IN cord-021413-1ht1xm88 495 2 a a DT cord-021413-1ht1xm88 495 3 conventional conventional JJ cord-021413-1ht1xm88 495 4 colony colony NN cord-021413-1ht1xm88 495 5 of of IN cord-021413-1ht1xm88 495 6 DDD DDD NNP cord-021413-1ht1xm88 495 7 mice mouse NNS cord-021413-1ht1xm88 495 8 , , , cord-021413-1ht1xm88 495 9 furthermore furthermore RB cord-021413-1ht1xm88 495 10 , , , cord-021413-1ht1xm88 495 11 seropositivity seropositivity NN cord-021413-1ht1xm88 495 12 increased increase VBD cord-021413-1ht1xm88 495 13 from from IN cord-021413-1ht1xm88 495 14 0 0 CD cord-021413-1ht1xm88 495 15 to to IN cord-021413-1ht1xm88 495 16 12 12 CD cord-021413-1ht1xm88 495 17 % % NN cord-021413-1ht1xm88 495 18 and and CC cord-021413-1ht1xm88 495 19 in in IN cord-021413-1ht1xm88 495 20 ddY ddy JJ cord-021413-1ht1xm88 495 21 mice mouse NNS cord-021413-1ht1xm88 495 22 from from IN cord-021413-1ht1xm88 495 23 6.3 6.3 CD cord-021413-1ht1xm88 495 24 to to TO cord-021413-1ht1xm88 495 25 45 45 CD cord-021413-1ht1xm88 495 26 % % NN cord-021413-1ht1xm88 495 27 as as IN cord-021413-1ht1xm88 495 28 a a DT cord-021413-1ht1xm88 495 29 result result NN cord-021413-1ht1xm88 495 30 of of IN cord-021413-1ht1xm88 495 31 the the DT cord-021413-1ht1xm88 495 32 booster booster NN cord-021413-1ht1xm88 495 33 technique technique NN cord-021413-1ht1xm88 495 34 . . . cord-021413-1ht1xm88 496 1 In in IN cord-021413-1ht1xm88 496 2 barrier barrier NN cord-021413-1ht1xm88 496 3 - - HYPH cord-021413-1ht1xm88 496 4 maintained maintain VBN cord-021413-1ht1xm88 496 5 animals animal NNS cord-021413-1ht1xm88 496 6 , , , cord-021413-1ht1xm88 496 7 the the DT cord-021413-1ht1xm88 496 8 booster booster NN cord-021413-1ht1xm88 496 9 did do VBD cord-021413-1ht1xm88 496 10 not not RB cord-021413-1ht1xm88 496 11 elicit elicit VB cord-021413-1ht1xm88 496 12 antibodies antibody NNS cord-021413-1ht1xm88 496 13 where where WRB cord-021413-1ht1xm88 496 14 there there EX cord-021413-1ht1xm88 496 15 had have VBD cord-021413-1ht1xm88 496 16 been be VBN cord-021413-1ht1xm88 496 17 none none NN cord-021413-1ht1xm88 496 18 before before RB cord-021413-1ht1xm88 496 19 . . . cord-021413-1ht1xm88 497 1 Presumably presumably RB cord-021413-1ht1xm88 497 2 , , , cord-021413-1ht1xm88 497 3 these these DT cord-021413-1ht1xm88 497 4 animals animal NNS cord-021413-1ht1xm88 497 5 were be VBD cord-021413-1ht1xm88 497 6 free free JJ cord-021413-1ht1xm88 497 7 from from IN cord-021413-1ht1xm88 497 8 MHV MHV NNP cord-021413-1ht1xm88 497 9 infection infection NN cord-021413-1ht1xm88 497 10 . . . cord-021413-1ht1xm88 498 1 From from IN cord-021413-1ht1xm88 498 2 the the DT cord-021413-1ht1xm88 498 3 foregoing forego VBG cord-021413-1ht1xm88 498 4 , , , cord-021413-1ht1xm88 498 5 it -PRON- PRP cord-021413-1ht1xm88 498 6 is be VBZ cord-021413-1ht1xm88 498 7 evident evident JJ cord-021413-1ht1xm88 498 8 that that IN cord-021413-1ht1xm88 498 9 the the DT cord-021413-1ht1xm88 498 10 classic classic JJ cord-021413-1ht1xm88 498 11 humoral humoral JJ cord-021413-1ht1xm88 498 12 immune immune JJ cord-021413-1ht1xm88 498 13 response response NN cord-021413-1ht1xm88 498 14 to to IN cord-021413-1ht1xm88 498 15 MHV MHV NNP cord-021413-1ht1xm88 498 16 seems seem VBZ cord-021413-1ht1xm88 498 17 to to TO cord-021413-1ht1xm88 498 18 be be VB cord-021413-1ht1xm88 498 19 weak weak JJ cord-021413-1ht1xm88 498 20 , , , cord-021413-1ht1xm88 498 21 and and CC cord-021413-1ht1xm88 498 22 that that IN cord-021413-1ht1xm88 498 23 a a DT cord-021413-1ht1xm88 498 24 colony colony NN cord-021413-1ht1xm88 499 1 In in IN cord-021413-1ht1xm88 499 2 contrast contrast NN cord-021413-1ht1xm88 499 3 to to IN cord-021413-1ht1xm88 499 4 the the DT cord-021413-1ht1xm88 499 5 findings finding NNS cord-021413-1ht1xm88 499 6 of of IN cord-021413-1ht1xm88 499 7 Bang Bang NNP cord-021413-1ht1xm88 499 8 and and CC cord-021413-1ht1xm88 499 9 Warwick Warwick NNP cord-021413-1ht1xm88 499 10 ( ( -LRB- cord-021413-1ht1xm88 499 11 1960 1960 CD cord-021413-1ht1xm88 499 12 ) ) -RRB- cord-021413-1ht1xm88 499 13 , , , cord-021413-1ht1xm88 499 14 who who WP cord-021413-1ht1xm88 499 15 concluded conclude VBD cord-021413-1ht1xm88 499 16 that that IN cord-021413-1ht1xm88 499 17 one one CD cord-021413-1ht1xm88 499 18 gene gene NN cord-021413-1ht1xm88 499 19 ( ( -LRB- cord-021413-1ht1xm88 499 20 or or CC cord-021413-1ht1xm88 499 21 factor factor NN cord-021413-1ht1xm88 499 22 ) ) -RRB- cord-021413-1ht1xm88 499 23 was be VBD cord-021413-1ht1xm88 499 24 responsible responsible JJ cord-021413-1ht1xm88 499 25 for for IN cord-021413-1ht1xm88 499 26 host host NN cord-021413-1ht1xm88 499 27 susceptibility susceptibility NN cord-021413-1ht1xm88 499 28 in in IN cord-021413-1ht1xm88 499 29 MHV2 MHV2 NNP cord-021413-1ht1xm88 499 30 infection infection NN cord-021413-1ht1xm88 499 31 , , , cord-021413-1ht1xm88 499 32 Stohlmann Stohlmann NNP cord-021413-1ht1xm88 499 33 and and CC cord-021413-1ht1xm88 499 34 Freiinger Freiinger NNP cord-021413-1ht1xm88 499 35 ( ( -LRB- cord-021413-1ht1xm88 499 36 1978 1978 CD cord-021413-1ht1xm88 499 37 ) ) -RRB- cord-021413-1ht1xm88 499 38 showed show VBD cord-021413-1ht1xm88 499 39 that that IN cord-021413-1ht1xm88 499 40 two two CD cord-021413-1ht1xm88 499 41 genes gene NNS cord-021413-1ht1xm88 499 42 are be VBP cord-021413-1ht1xm88 499 43 required require VBN cord-021413-1ht1xm88 499 44 for for IN cord-021413-1ht1xm88 499 45 resistance resistance NN cord-021413-1ht1xm88 499 46 of of IN cord-021413-1ht1xm88 499 47 the the DT cord-021413-1ht1xm88 499 48 central central JJ cord-021413-1ht1xm88 499 49 nervous nervous JJ cord-021413-1ht1xm88 499 50 system system NN cord-021413-1ht1xm88 499 51 in in IN cord-021413-1ht1xm88 499 52 SJL SJL NNP cord-021413-1ht1xm88 499 53 mice mouse NNS cord-021413-1ht1xm88 499 54 to to IN cord-021413-1ht1xm88 499 55 fatal fatal JJ cord-021413-1ht1xm88 499 56 disease disease NN cord-021413-1ht1xm88 499 57 due due IN cord-021413-1ht1xm88 499 58 to to IN cord-021413-1ht1xm88 499 59 MHV MHV NNP cord-021413-1ht1xm88 499 60 - - HYPH cord-021413-1ht1xm88 499 61 JHM JHM NNP cord-021413-1ht1xm88 499 62 . . . cord-021413-1ht1xm88 500 1 Further further RB cord-021413-1ht1xm88 500 2 , , , cord-021413-1ht1xm88 500 3 Stohlmann Stohlmann NNP cord-021413-1ht1xm88 500 4 et et NNP cord-021413-1ht1xm88 500 5 al al NNP cord-021413-1ht1xm88 500 6 . . . cord-021413-1ht1xm88 501 1 ( ( -LRB- cord-021413-1ht1xm88 501 2 1980 1980 CD cord-021413-1ht1xm88 501 3 ) ) -RRB- cord-021413-1ht1xm88 501 4 reported report VBD cord-021413-1ht1xm88 501 5 that that IN cord-021413-1ht1xm88 501 6 there there EX cord-021413-1ht1xm88 501 7 is be VBZ cord-021413-1ht1xm88 501 8 an an DT cord-021413-1ht1xm88 501 9 age age NN cord-021413-1ht1xm88 501 10 - - HYPH cord-021413-1ht1xm88 501 11 related relate VBN cord-021413-1ht1xm88 501 12 change change NN cord-021413-1ht1xm88 501 13 in in IN cord-021413-1ht1xm88 501 14 resistant resistant JJ cord-021413-1ht1xm88 501 15 mice mouse NNS cord-021413-1ht1xm88 501 16 that that WDT cord-021413-1ht1xm88 501 17 protects protect VBZ cord-021413-1ht1xm88 501 18 them -PRON- PRP cord-021413-1ht1xm88 501 19 from from IN cord-021413-1ht1xm88 501 20 acute acute JJ cord-021413-1ht1xm88 501 21 central central JJ cord-021413-1ht1xm88 501 22 nervous nervous JJ cord-021413-1ht1xm88 501 23 system system NN cord-021413-1ht1xm88 501 24 disease disease NN cord-021413-1ht1xm88 501 25 . . . cord-021413-1ht1xm88 502 1 They -PRON- PRP cord-021413-1ht1xm88 502 2 iden iden NNP cord-021413-1ht1xm88 502 3 tified tifie VBD cord-021413-1ht1xm88 502 4 this this DT cord-021413-1ht1xm88 502 5 change change NN cord-021413-1ht1xm88 502 6 as as IN cord-021413-1ht1xm88 502 7 due due IN cord-021413-1ht1xm88 502 8 to to IN cord-021413-1ht1xm88 502 9 a a DT cord-021413-1ht1xm88 502 10 maturing mature VBG cord-021413-1ht1xm88 502 11 adherent adherent JJ cord-021413-1ht1xm88 502 12 spleen spleen NNS cord-021413-1ht1xm88 502 13 or or CC cord-021413-1ht1xm88 502 14 peritoneal peritoneal JJ cord-021413-1ht1xm88 502 15 exudate exudate NN cord-021413-1ht1xm88 502 16 cell cell NN cord-021413-1ht1xm88 502 17 population population NN cord-021413-1ht1xm88 502 18 . . . cord-021413-1ht1xm88 503 1 In in IN cord-021413-1ht1xm88 503 2 extensive extensive JJ cord-021413-1ht1xm88 503 3 genetic genetic JJ cord-021413-1ht1xm88 503 4 studies study NNS cord-021413-1ht1xm88 503 5 , , , cord-021413-1ht1xm88 503 6 Levy Levy NNP cord-021413-1ht1xm88 503 7 - - HYPH cord-021413-1ht1xm88 503 8 LeBlond LeBlond NNP cord-021413-1ht1xm88 503 9 et et FW cord-021413-1ht1xm88 503 10 al al NNP cord-021413-1ht1xm88 503 11 . . . cord-021413-1ht1xm88 504 1 ( ( -LRB- cord-021413-1ht1xm88 504 2 1979 1979 CD cord-021413-1ht1xm88 504 3 ) ) -RRB- cord-021413-1ht1xm88 504 4 found find VBD cord-021413-1ht1xm88 504 5 no no DT cord-021413-1ht1xm88 504 6 correlation correlation NN cord-021413-1ht1xm88 504 7 between between IN cord-021413-1ht1xm88 504 8 the the DT cord-021413-1ht1xm88 504 9 H-2 H-2 NNP cord-021413-1ht1xm88 504 10 locus locus NN cord-021413-1ht1xm88 504 11 and and CC cord-021413-1ht1xm88 504 12 either either CC cord-021413-1ht1xm88 504 13 the the DT cord-021413-1ht1xm88 504 14 acute acute JJ cord-021413-1ht1xm88 504 15 or or CC cord-021413-1ht1xm88 504 16 chronic chronic JJ cord-021413-1ht1xm88 504 17 disease disease NN cord-021413-1ht1xm88 504 18 in in IN cord-021413-1ht1xm88 504 19 C57BL c57bl NN cord-021413-1ht1xm88 504 20 ( ( -LRB- cord-021413-1ht1xm88 504 21 susceptible susceptible JJ cord-021413-1ht1xm88 504 22 ) ) -RRB- cord-021413-1ht1xm88 504 23 or or CC cord-021413-1ht1xm88 504 24 A A NNP cord-021413-1ht1xm88 504 25 / / SYM cord-021413-1ht1xm88 504 26 J J NNP cord-021413-1ht1xm88 504 27 ( ( -LRB- cord-021413-1ht1xm88 504 28 resistant resistant JJ cord-021413-1ht1xm88 504 29 ) ) -RRB- cord-021413-1ht1xm88 504 30 animals animal NNS cord-021413-1ht1xm88 504 31 . . . cord-021413-1ht1xm88 505 1 Using use VBG cord-021413-1ht1xm88 505 2 congenie congenie NNP cord-021413-1ht1xm88 505 3 C3H C3H NNP cord-021413-1ht1xm88 505 4 lines line NNS cord-021413-1ht1xm88 505 5 , , , cord-021413-1ht1xm88 505 6 however however RB cord-021413-1ht1xm88 505 7 , , , cord-021413-1ht1xm88 505 8 they -PRON- PRP cord-021413-1ht1xm88 505 9 were be VBD cord-021413-1ht1xm88 505 10 able able JJ cord-021413-1ht1xm88 505 11 to to TO cord-021413-1ht1xm88 505 12 show show VB cord-021413-1ht1xm88 505 13 that that IN cord-021413-1ht1xm88 505 14 the the DT cord-021413-1ht1xm88 505 15 H-2^ H-2^ NNP cord-021413-1ht1xm88 505 16 allele allele NN cord-021413-1ht1xm88 505 17 enables enable VBZ cord-021413-1ht1xm88 505 18 both both CC cord-021413-1ht1xm88 505 19 heterozygous heterozygous JJ cord-021413-1ht1xm88 505 20 and and CC cord-021413-1ht1xm88 505 21 homozygous homozygous JJ cord-021413-1ht1xm88 505 22 animals animal NNS cord-021413-1ht1xm88 505 23 to to TO cord-021413-1ht1xm88 505 24 resist resist VB cord-021413-1ht1xm88 505 25 the the DT cord-021413-1ht1xm88 505 26 development development NN cord-021413-1ht1xm88 505 27 of of IN cord-021413-1ht1xm88 505 28 the the DT cord-021413-1ht1xm88 505 29 chronic chronic JJ cord-021413-1ht1xm88 505 30 disease disease NN cord-021413-1ht1xm88 505 31 . . . cord-021413-1ht1xm88 506 1 They -PRON- PRP cord-021413-1ht1xm88 506 2 believe believe VBP cord-021413-1ht1xm88 506 3 , , , cord-021413-1ht1xm88 506 4 therefore therefore RB cord-021413-1ht1xm88 506 5 , , , cord-021413-1ht1xm88 506 6 that that IN cord-021413-1ht1xm88 506 7 MHV MHV NNP cord-021413-1ht1xm88 506 8 sensitivity sensitivity NN cord-021413-1ht1xm88 506 9 appears appear VBZ cord-021413-1ht1xm88 506 10 to to TO cord-021413-1ht1xm88 506 11 be be VB cord-021413-1ht1xm88 506 12 influenced influence VBN cord-021413-1ht1xm88 506 13 by by IN cord-021413-1ht1xm88 506 14 at at RB cord-021413-1ht1xm88 506 15 least least RBS cord-021413-1ht1xm88 506 16 two two CD cord-021413-1ht1xm88 506 17 major major JJ cord-021413-1ht1xm88 506 18 genes gene NNS cord-021413-1ht1xm88 506 19 : : : cord-021413-1ht1xm88 506 20 one one CD cord-021413-1ht1xm88 506 21 for for IN cord-021413-1ht1xm88 506 22 the the DT cord-021413-1ht1xm88 506 23 acute acute JJ cord-021413-1ht1xm88 506 24 disease disease NN cord-021413-1ht1xm88 506 25 , , , cord-021413-1ht1xm88 506 26 and and CC cord-021413-1ht1xm88 506 27 the the DT cord-021413-1ht1xm88 506 28 other other JJ cord-021413-1ht1xm88 506 29 , , , cord-021413-1ht1xm88 506 30 linked link VBN cord-021413-1ht1xm88 506 31 to to IN cord-021413-1ht1xm88 506 32 the the DT cord-021413-1ht1xm88 506 33 H-2 H-2 NNP cord-021413-1ht1xm88 506 34 gene gene NN cord-021413-1ht1xm88 506 35 complex complex NN cord-021413-1ht1xm88 506 36 , , , cord-021413-1ht1xm88 506 37 for for IN cord-021413-1ht1xm88 506 38 the the DT cord-021413-1ht1xm88 506 39 chronic chronic JJ cord-021413-1ht1xm88 506 40 disease disease NN cord-021413-1ht1xm88 506 41 . . . cord-021413-1ht1xm88 507 1 Mice mouse NNS cord-021413-1ht1xm88 507 2 also also RB cord-021413-1ht1xm88 507 3 produce produce VBP cord-021413-1ht1xm88 507 4 interferon interferon NN cord-021413-1ht1xm88 507 5 as as IN cord-021413-1ht1xm88 507 6 a a DT cord-021413-1ht1xm88 507 7 result result NN cord-021413-1ht1xm88 507 8 of of IN cord-021413-1ht1xm88 507 9 MHV MHV NNP cord-021413-1ht1xm88 507 10 infection infection NN cord-021413-1ht1xm88 507 11 Virelizier Virelizier NNP cord-021413-1ht1xm88 507 12 and and CC cord-021413-1ht1xm88 507 13 Gresser Gresser NNP cord-021413-1ht1xm88 507 14 , , , cord-021413-1ht1xm88 507 15 1978 1978 CD cord-021413-1ht1xm88 507 16 ) ) -RRB- cord-021413-1ht1xm88 507 17 , , , cord-021413-1ht1xm88 507 18 and and CC cord-021413-1ht1xm88 507 19 Taguchi Taguchi NNP cord-021413-1ht1xm88 507 20 et et NNP cord-021413-1ht1xm88 507 21 aL aL NNP cord-021413-1ht1xm88 507 22 ( ( -LRB- cord-021413-1ht1xm88 507 23 1979a 1979a CD cord-021413-1ht1xm88 507 24 ) ) -RRB- cord-021413-1ht1xm88 507 25 ascribe ascribe VBP cord-021413-1ht1xm88 507 26 the the DT cord-021413-1ht1xm88 507 27 greater great JJR cord-021413-1ht1xm88 507 28 susceptibility susceptibility NN cord-021413-1ht1xm88 507 29 of of IN cord-021413-1ht1xm88 507 30 suckling suckle VBG cord-021413-1ht1xm88 507 31 C3H c3h RB cord-021413-1ht1xm88 507 32 / / SYM cord-021413-1ht1xm88 507 33 HeJms HeJms NNP cord-021413-1ht1xm88 507 34 mice mouse NNS cord-021413-1ht1xm88 507 35 to to IN cord-021413-1ht1xm88 507 36 serum serum NN cord-021413-1ht1xm88 507 37 levels level NNS cord-021413-1ht1xm88 507 38 of of IN cord-021413-1ht1xm88 507 39 interferon interferon NN cord-021413-1ht1xm88 507 40 that that WDT cord-021413-1ht1xm88 507 41 are be VBP cord-021413-1ht1xm88 507 42 considerably considerably RB cord-021413-1ht1xm88 507 43 lower low JJR cord-021413-1ht1xm88 507 44 than than IN cord-021413-1ht1xm88 507 45 in in IN cord-021413-1ht1xm88 507 46 weanling weanle VBG cord-021413-1ht1xm88 507 47 and and CC cord-021413-1ht1xm88 507 48 aduh aduh NNP cord-021413-1ht1xm88 507 49 mice mouse NNS cord-021413-1ht1xm88 507 50 , , , cord-021413-1ht1xm88 507 51 as as RB cord-021413-1ht1xm88 507 52 well well RB cord-021413-1ht1xm88 507 53 as as IN cord-021413-1ht1xm88 507 54 to to IN cord-021413-1ht1xm88 507 55 greater great JJR cord-021413-1ht1xm88 507 56 macrophage macrophage NN cord-021413-1ht1xm88 507 57 sensitivity sensitivity NN cord-021413-1ht1xm88 507 58 in in IN cord-021413-1ht1xm88 507 59 the the DT cord-021413-1ht1xm88 507 60 neonates neonate NNS cord-021413-1ht1xm88 507 61 . . . cord-021413-1ht1xm88 508 1 MHV mhv NN cord-021413-1ht1xm88 508 2 - - HYPH cord-021413-1ht1xm88 508 3 induced induce VBN cord-021413-1ht1xm88 508 4 interferon interferon NN cord-021413-1ht1xm88 508 5 may may MD cord-021413-1ht1xm88 508 6 be be VB cord-021413-1ht1xm88 508 7 regarded regard VBN cord-021413-1ht1xm88 508 8 as as IN cord-021413-1ht1xm88 508 9 the the DT cord-021413-1ht1xm88 508 10 principal principal JJ cord-021413-1ht1xm88 508 11 mechanism mechanism NN cord-021413-1ht1xm88 508 12 by by IN cord-021413-1ht1xm88 508 13 which which WDT cord-021413-1ht1xm88 508 14 the the DT cord-021413-1ht1xm88 508 15 virus virus NN cord-021413-1ht1xm88 508 16 modifies modify VBZ cord-021413-1ht1xm88 508 17 the the DT cord-021413-1ht1xm88 508 18 immune immune JJ cord-021413-1ht1xm88 508 19 respon respon NNP cord-021413-1ht1xm88 508 20 siveness siveness NNP cord-021413-1ht1xm88 508 21 of of IN cord-021413-1ht1xm88 508 22 mice mouse NNS cord-021413-1ht1xm88 508 23 to to TO cord-021413-1ht1xm88 508 24 sheep sheep VB cord-021413-1ht1xm88 508 25 red red JJ cord-021413-1ht1xm88 508 26 blood blood NN cord-021413-1ht1xm88 508 27 cells cell NNS cord-021413-1ht1xm88 508 28 , , , cord-021413-1ht1xm88 508 29 for for IN cord-021413-1ht1xm88 508 30 example example NN cord-021413-1ht1xm88 508 31 . . . cord-021413-1ht1xm88 509 1 ( ( -LRB- cord-021413-1ht1xm88 509 2 See see VB cord-021413-1ht1xm88 509 3 also also RB cord-021413-1ht1xm88 509 4 ( ( -LRB- cord-021413-1ht1xm88 509 5 1949 1949 CD cord-021413-1ht1xm88 509 6 ) ) -RRB- cord-021413-1ht1xm88 509 7 infected infect VBN cord-021413-1ht1xm88 509 8 cotton cotton NN cord-021413-1ht1xm88 509 9 rats rat NNS cord-021413-1ht1xm88 509 10 , , , cord-021413-1ht1xm88 509 11 rats rat NNS cord-021413-1ht1xm88 509 12 , , , cord-021413-1ht1xm88 509 13 and and CC cord-021413-1ht1xm88 509 14 hamsters hamster NNS cord-021413-1ht1xm88 509 15 intracerebrally intracerebrally RB cord-021413-1ht1xm88 509 16 , , , cord-021413-1ht1xm88 509 17 but but CC cord-021413-1ht1xm88 509 18 rabbits rabbit NNS cord-021413-1ht1xm88 509 19 and and CC cord-021413-1ht1xm88 509 20 guinea guinea NN cord-021413-1ht1xm88 509 21 pigs pig NNS cord-021413-1ht1xm88 509 22 failed fail VBD cord-021413-1ht1xm88 509 23 to to TO cord-021413-1ht1xm88 509 24 respond respond VB cord-021413-1ht1xm88 509 25 . . . cord-021413-1ht1xm88 510 1 Sebesteny Sebesteny NNP cord-021413-1ht1xm88 510 2 and and CC cord-021413-1ht1xm88 510 3 Hill Hill NNP cord-021413-1ht1xm88 510 4 ( ( -LRB- cord-021413-1ht1xm88 510 5 1974 1974 CD cord-021413-1ht1xm88 510 6 ) ) -RRB- cord-021413-1ht1xm88 510 7 at at IN cord-021413-1ht1xm88 510 8 tempted tempt VBN cord-021413-1ht1xm88 510 9 to to TO cord-021413-1ht1xm88 510 10 infect infect VB cord-021413-1ht1xm88 510 11 infant infant JJ cord-021413-1ht1xm88 510 12 Wistar Wistar NNP cord-021413-1ht1xm88 510 13 rats rat NNS cord-021413-1ht1xm88 510 14 and and CC cord-021413-1ht1xm88 510 15 hamsters hamster NNS cord-021413-1ht1xm88 510 16 using use VBG cord-021413-1ht1xm88 510 17 virus virus NN cord-021413-1ht1xm88 510 18 recovered recover VBN cord-021413-1ht1xm88 510 19 from from IN cord-021413-1ht1xm88 510 20 nude nude JJ cord-021413-1ht1xm88 510 21 mice mouse NNS cord-021413-1ht1xm88 510 22 . . . cord-021413-1ht1xm88 511 1 All all DT cord-021413-1ht1xm88 511 2 survived survive VBD cord-021413-1ht1xm88 511 3 at at IN cord-021413-1ht1xm88 511 4 least least RBS cord-021413-1ht1xm88 511 5 21 21 CD cord-021413-1ht1xm88 511 6 days day NNS cord-021413-1ht1xm88 511 7 with with IN cord-021413-1ht1xm88 511 8 out out JJ cord-021413-1ht1xm88 511 9 signs sign NNS cord-021413-1ht1xm88 511 10 of of IN cord-021413-1ht1xm88 511 11 illness illness NN cord-021413-1ht1xm88 511 12 . . . cord-021413-1ht1xm88 512 1 Of of IN cord-021413-1ht1xm88 512 2 considerable considerable JJ cord-021413-1ht1xm88 512 3 importance importance NN cord-021413-1ht1xm88 512 4 is be VBZ cord-021413-1ht1xm88 512 5 a a DT cord-021413-1ht1xm88 512 6 report report NN cord-021413-1ht1xm88 512 7 by by IN cord-021413-1ht1xm88 512 8 Taguchi Taguchi NNP cord-021413-1ht1xm88 512 9 et et NNP cord-021413-1ht1xm88 512 10 aL aL NNP cord-021413-1ht1xm88 512 11 ( ( -LRB- cord-021413-1ht1xm88 512 12 1979c 1979c CD cord-021413-1ht1xm88 512 13 ) ) -RRB- cord-021413-1ht1xm88 512 14 concerning concern VBG cord-021413-1ht1xm88 512 15 asymptomatic asymptomatic JJ cord-021413-1ht1xm88 512 16 MHV MHV NNP cord-021413-1ht1xm88 512 17 - - HYPH cord-021413-1ht1xm88 512 18 S s NN cord-021413-1ht1xm88 512 19 infection infection NN cord-021413-1ht1xm88 512 20 in in IN cord-021413-1ht1xm88 512 21 suckl suckl JJ cord-021413-1ht1xm88 512 22 ing e VBG cord-021413-1ht1xm88 512 23 rats rat NNS cord-021413-1ht1xm88 512 24 following follow VBG cord-021413-1ht1xm88 512 25 intranasal intranasal NN cord-021413-1ht1xm88 512 26 inoculation inoculation NN cord-021413-1ht1xm88 512 27 . . . cord-021413-1ht1xm88 513 1 The the DT cord-021413-1ht1xm88 513 2 agent agent NN cord-021413-1ht1xm88 513 3 multiplied multiply VBD cord-021413-1ht1xm88 513 4 mainly mainly RB cord-021413-1ht1xm88 513 5 in in IN cord-021413-1ht1xm88 513 6 the the DT cord-021413-1ht1xm88 513 7 nasal nasal NN cord-021413-1ht1xm88 513 8 epithelium epithelium NN cord-021413-1ht1xm88 513 9 without without IN cord-021413-1ht1xm88 513 10 any any DT cord-021413-1ht1xm88 513 11 clinical clinical JJ cord-021413-1ht1xm88 513 12 signs sign NNS cord-021413-1ht1xm88 513 13 . . . cord-021413-1ht1xm88 514 1 Neu Neu NNP cord-021413-1ht1xm88 514 2 tralizing tralize VBG cord-021413-1ht1xm88 514 3 antibodies antibody NNS cord-021413-1ht1xm88 514 4 were be VBD cord-021413-1ht1xm88 514 5 produced produce VBN cord-021413-1ht1xm88 514 6 , , , cord-021413-1ht1xm88 514 7 however however RB cord-021413-1ht1xm88 514 8 , , , cord-021413-1ht1xm88 514 9 and and CC cord-021413-1ht1xm88 514 10 could could MD cord-021413-1ht1xm88 514 11 also also RB cord-021413-1ht1xm88 514 12 be be VB cord-021413-1ht1xm88 514 13 demonstrated demonstrate VBN cord-021413-1ht1xm88 514 14 in in IN cord-021413-1ht1xm88 514 15 adult adult NN cord-021413-1ht1xm88 514 16 rats rat NNS cord-021413-1ht1xm88 514 17 following follow VBG cord-021413-1ht1xm88 514 18 infection infection NN cord-021413-1ht1xm88 514 19 . . . cord-021413-1ht1xm88 515 1 Necrotic necrotic JJ cord-021413-1ht1xm88 515 2 changes change NNS cord-021413-1ht1xm88 515 3 took take VBD cord-021413-1ht1xm88 515 4 place place NN cord-021413-1ht1xm88 515 5 in in IN cord-021413-1ht1xm88 515 6 the the DT cord-021413-1ht1xm88 515 7 nasal nasal NN cord-021413-1ht1xm88 515 8 mucosa mucosa NN cord-021413-1ht1xm88 515 9 , , , cord-021413-1ht1xm88 515 10 and and CC cord-021413-1ht1xm88 515 11 cytoplasmic cytoplasmic JJ cord-021413-1ht1xm88 515 12 i -PRON- PRP cord-021413-1ht1xm88 515 13 m be VBP cord-021413-1ht1xm88 515 14 munofluorescence munofluorescence NN cord-021413-1ht1xm88 515 15 was be VBD cord-021413-1ht1xm88 515 16 demonstrated demonstrate VBN cord-021413-1ht1xm88 515 17 in in IN cord-021413-1ht1xm88 515 18 the the DT cord-021413-1ht1xm88 515 19 nasal nasal NN cord-021413-1ht1xm88 515 20 epithelium epithelium NN cord-021413-1ht1xm88 515 21 2 2 CD cord-021413-1ht1xm88 515 22 days day NNS cord-021413-1ht1xm88 515 23 after after IN cord-021413-1ht1xm88 515 24 intranasal intranasal NN cord-021413-1ht1xm88 515 25 inoculation inoculation NN cord-021413-1ht1xm88 515 26 of of IN cord-021413-1ht1xm88 515 27 10-day 10-day CD cord-021413-1ht1xm88 515 28 - - HYPH cord-021413-1ht1xm88 515 29 old old JJ cord-021413-1ht1xm88 515 30 rats rat NNS cord-021413-1ht1xm88 515 31 . . . cord-021413-1ht1xm88 516 1 Age age NN cord-021413-1ht1xm88 516 2 susceptibility susceptibility NN cord-021413-1ht1xm88 516 3 has have VBZ cord-021413-1ht1xm88 516 4 been be VBN cord-021413-1ht1xm88 516 5 amply amply RB cord-021413-1ht1xm88 516 6 addressed address VBN cord-021413-1ht1xm88 516 7 above above RB cord-021413-1ht1xm88 516 8 in in IN cord-021413-1ht1xm88 516 9 the the DT cord-021413-1ht1xm88 516 10 consideration consideration NN cord-021413-1ht1xm88 516 11 of of IN cord-021413-1ht1xm88 516 12 virus virus NN cord-021413-1ht1xm88 516 13 growth growth NN cord-021413-1ht1xm88 516 14 in in IN cord-021413-1ht1xm88 516 15 mice mouse NNS cord-021413-1ht1xm88 516 16 and and CC cord-021413-1ht1xm88 516 17 tissue tissue NN cord-021413-1ht1xm88 516 18 culture culture NN cord-021413-1ht1xm88 516 19 and and CC cord-021413-1ht1xm88 516 20 in in IN cord-021413-1ht1xm88 516 21 the the DT cord-021413-1ht1xm88 516 22 discussion discussion NN cord-021413-1ht1xm88 516 23 of of IN cord-021413-1ht1xm88 516 24 the the DT cord-021413-1ht1xm88 516 25 clinical clinical JJ cord-021413-1ht1xm88 516 26 picture picture NN cord-021413-1ht1xm88 516 27 . . . cord-021413-1ht1xm88 517 1 There there EX cord-021413-1ht1xm88 517 2 appears appear VBZ cord-021413-1ht1xm88 517 3 to to TO cord-021413-1ht1xm88 517 4 be be VB cord-021413-1ht1xm88 517 5 no no DT cord-021413-1ht1xm88 517 6 difference difference NN cord-021413-1ht1xm88 517 7 in in IN cord-021413-1ht1xm88 517 8 susceptibility susceptibility NN cord-021413-1ht1xm88 517 9 between between IN cord-021413-1ht1xm88 517 10 the the DT cord-021413-1ht1xm88 517 11 sexes sex NNS cord-021413-1ht1xm88 517 12 ( ( -LRB- cord-021413-1ht1xm88 517 13 Taguchi Taguchi NNP cord-021413-1ht1xm88 517 14 et et NNP cord-021413-1ht1xm88 517 15 al al NNP cord-021413-1ht1xm88 517 16 . . NNP cord-021413-1ht1xm88 517 17 , , , cord-021413-1ht1xm88 517 18 1976 1976 CD cord-021413-1ht1xm88 517 19 ) ) -RRB- cord-021413-1ht1xm88 517 20 . . . cord-021413-1ht1xm88 518 1 Parker Parker NNP cord-021413-1ht1xm88 518 2 et et NNP cord-021413-1ht1xm88 518 3 al al NNP cord-021413-1ht1xm88 518 4 . . . cord-021413-1ht1xm88 519 1 ( ( -LRB- cord-021413-1ht1xm88 519 2 1966 1966 CD cord-021413-1ht1xm88 519 3 ) ) -RRB- cord-021413-1ht1xm88 519 4 found find VBD cord-021413-1ht1xm88 519 5 that that IN cord-021413-1ht1xm88 519 6 the the DT cord-021413-1ht1xm88 519 7 incidence incidence NN cord-021413-1ht1xm88 519 8 of of IN cord-021413-1ht1xm88 519 9 complement complement NN cord-021413-1ht1xm88 519 10 - - HYPH cord-021413-1ht1xm88 519 11 fixing fix VBG cord-021413-1ht1xm88 519 12 antibodies antibody NNS cord-021413-1ht1xm88 519 13 was be VBD cord-021413-1ht1xm88 519 14 greater great JJR cord-021413-1ht1xm88 519 15 in in IN cord-021413-1ht1xm88 519 16 females female NNS cord-021413-1ht1xm88 519 17 than than IN cord-021413-1ht1xm88 519 18 in in IN cord-021413-1ht1xm88 519 19 males male NNS cord-021413-1ht1xm88 519 20 under under IN cord-021413-1ht1xm88 519 21 colony colony NN cord-021413-1ht1xm88 519 22 conditions condition NNS cord-021413-1ht1xm88 519 23 , , , cord-021413-1ht1xm88 519 24 as as IN cord-021413-1ht1xm88 519 25 cribing crib VBG cord-021413-1ht1xm88 519 26 this this DT cord-021413-1ht1xm88 519 27 difference difference NN cord-021413-1ht1xm88 519 28 to to IN cord-021413-1ht1xm88 519 29 continual continual JJ cord-021413-1ht1xm88 519 30 exposure exposure NN cord-021413-1ht1xm88 519 31 to to IN cord-021413-1ht1xm88 519 32 virus virus NN cord-021413-1ht1xm88 519 33 - - HYPH cord-021413-1ht1xm88 519 34 infected infect VBN cord-021413-1ht1xm88 519 35 litters litter NNS cord-021413-1ht1xm88 519 36 . . . cord-021413-1ht1xm88 520 1 There there EX cord-021413-1ht1xm88 520 2 appears appear VBZ cord-021413-1ht1xm88 520 3 to to TO cord-021413-1ht1xm88 520 4 be be VB cord-021413-1ht1xm88 520 5 no no DT cord-021413-1ht1xm88 520 6 evidence evidence NN cord-021413-1ht1xm88 520 7 that that IN cord-021413-1ht1xm88 520 8 first first JJ cord-021413-1ht1xm88 520 9 litters litter NNS cord-021413-1ht1xm88 520 10 are be VBP cord-021413-1ht1xm88 520 11 significantly significantly RB cord-021413-1ht1xm88 520 12 more more RBR cord-021413-1ht1xm88 520 13 susceptible susceptible JJ cord-021413-1ht1xm88 520 14 than than IN cord-021413-1ht1xm88 520 15 later later JJ cord-021413-1ht1xm88 520 16 ones one NNS cord-021413-1ht1xm88 520 17 . . . cord-021413-1ht1xm88 521 1 As as IN cord-021413-1ht1xm88 521 2 noted note VBN cord-021413-1ht1xm88 521 3 above above IN cord-021413-1ht1xm88 521 4 ( ( -LRB- cord-021413-1ht1xm88 521 5 Section section NN cord-021413-1ht1xm88 521 6 IV IV NNP cord-021413-1ht1xm88 521 7 , , , cord-021413-1ht1xm88 521 8 Β β NN cord-021413-1ht1xm88 521 9 , , , cord-021413-1ht1xm88 521 10 2 2 CD cord-021413-1ht1xm88 521 11 and and CC cord-021413-1ht1xm88 521 12 C C NNP cord-021413-1ht1xm88 521 13 , , , cord-021413-1ht1xm88 521 14 l l NNP cord-021413-1ht1xm88 521 15 ) ) -RRB- cord-021413-1ht1xm88 521 16 , , , cord-021413-1ht1xm88 521 17 the the DT cord-021413-1ht1xm88 521 18 susceptibility susceptibility NN cord-021413-1ht1xm88 521 19 of of IN cord-021413-1ht1xm88 521 20 various various JJ cord-021413-1ht1xm88 521 21 mouse mouse NN cord-021413-1ht1xm88 521 22 strains strain NNS cord-021413-1ht1xm88 521 23 depends depend VBZ cord-021413-1ht1xm88 521 24 on on IN cord-021413-1ht1xm88 521 25 the the DT cord-021413-1ht1xm88 521 26 age age NN cord-021413-1ht1xm88 521 27 of of IN cord-021413-1ht1xm88 521 28 the the DT cord-021413-1ht1xm88 521 29 host host NN cord-021413-1ht1xm88 521 30 at at IN cord-021413-1ht1xm88 521 31 the the DT cord-021413-1ht1xm88 521 32 time time NN cord-021413-1ht1xm88 521 33 of of IN cord-021413-1ht1xm88 521 34 infection infection NN cord-021413-1ht1xm88 521 35 , , , cord-021413-1ht1xm88 521 36 the the DT cord-021413-1ht1xm88 521 37 virus virus NN cord-021413-1ht1xm88 521 38 strain strain NN cord-021413-1ht1xm88 521 39 , , , cord-021413-1ht1xm88 521 40 and and CC cord-021413-1ht1xm88 521 41 the the DT cord-021413-1ht1xm88 521 42 host host NN cord-021413-1ht1xm88 521 43 genotype genotype NN cord-021413-1ht1xm88 521 44 . . . cord-021413-1ht1xm88 522 1 A a DT cord-021413-1ht1xm88 522 2 completely completely RB cord-021413-1ht1xm88 522 3 resistant resistant JJ cord-021413-1ht1xm88 522 4 mouse mouse NN cord-021413-1ht1xm88 522 5 strain strain NN cord-021413-1ht1xm88 522 6 has have VBZ cord-021413-1ht1xm88 522 7 not not RB cord-021413-1ht1xm88 522 8 been be VBN cord-021413-1ht1xm88 522 9 reported report VBN cord-021413-1ht1xm88 522 10 . . . cord-021413-1ht1xm88 523 1 Prevalence prevalence NN cord-021413-1ht1xm88 523 2 of of IN cord-021413-1ht1xm88 523 3 MHV MHV NNP cord-021413-1ht1xm88 523 4 infection infection NN cord-021413-1ht1xm88 523 5 in in IN cord-021413-1ht1xm88 523 6 an an DT cord-021413-1ht1xm88 523 7 animal animal NN cord-021413-1ht1xm88 523 8 colony colony NN cord-021413-1ht1xm88 523 9 is be VBZ cord-021413-1ht1xm88 523 10 often often RB cord-021413-1ht1xm88 523 11 difficult difficult JJ cord-021413-1ht1xm88 523 12 to to TO cord-021413-1ht1xm88 523 13 ascertain ascertain VB cord-021413-1ht1xm88 523 14 . . . cord-021413-1ht1xm88 524 1 In in IN cord-021413-1ht1xm88 524 2 addition addition NN cord-021413-1ht1xm88 524 3 to to IN cord-021413-1ht1xm88 524 4 examples example NNS cord-021413-1ht1xm88 524 5 given give VBN cord-021413-1ht1xm88 524 6 earlier early RBR cord-021413-1ht1xm88 524 7 , , , cord-021413-1ht1xm88 524 8 Descoteaux Descoteaux NNP cord-021413-1ht1xm88 524 9 et et NNP cord-021413-1ht1xm88 524 10 al al NNP cord-021413-1ht1xm88 524 11 . . . cord-021413-1ht1xm88 525 1 ( ( -LRB- cord-021413-1ht1xm88 525 2 1977 1977 CD cord-021413-1ht1xm88 525 3 ) ) -RRB- cord-021413-1ht1xm88 525 4 found find VBD cord-021413-1ht1xm88 525 5 a a DT cord-021413-1ht1xm88 525 6 low low JJ cord-021413-1ht1xm88 525 7 prevalence prevalence NN cord-021413-1ht1xm88 525 8 of of IN cord-021413-1ht1xm88 525 9 hepatitis hepatitis NN cord-021413-1ht1xm88 525 10 antibodies antibody NNS cord-021413-1ht1xm88 525 11 in in IN cord-021413-1ht1xm88 525 12 three three CD cord-021413-1ht1xm88 525 13 of of IN cord-021413-1ht1xm88 525 14 five five CD cord-021413-1ht1xm88 525 15 colonies colony NNS cord-021413-1ht1xm88 525 16 studied study VBN cord-021413-1ht1xm88 525 17 in in IN cord-021413-1ht1xm88 525 18 Canada Canada NNP cord-021413-1ht1xm88 525 19 . . . cord-021413-1ht1xm88 526 1 Complement complement NN cord-021413-1ht1xm88 526 2 - - HYPH cord-021413-1ht1xm88 526 3 fixing fix VBG cord-021413-1ht1xm88 526 4 antibodies antibody NNS cord-021413-1ht1xm88 526 5 ranged range VBN cord-021413-1ht1xm88 526 6 in in IN cord-021413-1ht1xm88 526 7 titer titer NN cord-021413-1ht1xm88 526 8 from from IN cord-021413-1ht1xm88 526 9 8 8 CD cord-021413-1ht1xm88 526 10 to to IN cord-021413-1ht1xm88 526 11 32 32 CD cord-021413-1ht1xm88 526 12 , , , cord-021413-1ht1xm88 526 13 8 8 CD cord-021413-1ht1xm88 526 14 being be VBG cord-021413-1ht1xm88 526 15 considered consider VBN cord-021413-1ht1xm88 526 16 positive positive JJ cord-021413-1ht1xm88 526 17 . . . cord-021413-1ht1xm88 527 1 Fewer few JJR cord-021413-1ht1xm88 527 2 than than IN cord-021413-1ht1xm88 527 3 20 20 CD cord-021413-1ht1xm88 527 4 % % NN cord-021413-1ht1xm88 527 5 of of IN cord-021413-1ht1xm88 527 6 the the DT cord-021413-1ht1xm88 527 7 animals animal NNS cord-021413-1ht1xm88 527 8 , , , cord-021413-1ht1xm88 527 9 which which WDT cord-021413-1ht1xm88 527 10 were be VBD cord-021413-1ht1xm88 527 11 6 6 CD cord-021413-1ht1xm88 527 12 - - SYM cord-021413-1ht1xm88 527 13 9 9 CD cord-021413-1ht1xm88 527 14 months month NNS cord-021413-1ht1xm88 527 15 old old JJ cord-021413-1ht1xm88 527 16 at at IN cord-021413-1ht1xm88 527 17 the the DT cord-021413-1ht1xm88 527 18 time time NN cord-021413-1ht1xm88 527 19 of of IN cord-021413-1ht1xm88 527 20 testing testing NN cord-021413-1ht1xm88 527 21 , , , cord-021413-1ht1xm88 527 22 were be VBD cord-021413-1ht1xm88 527 23 posi posi JJ cord-021413-1ht1xm88 527 24 tive tive FW cord-021413-1ht1xm88 527 25 . . . cord-021413-1ht1xm88 528 1 In in IN cord-021413-1ht1xm88 528 2 distribution distribution NN cord-021413-1ht1xm88 528 3 , , , cord-021413-1ht1xm88 528 4 MHV MHV NNP cord-021413-1ht1xm88 528 5 is be VBZ cord-021413-1ht1xm88 528 6 regarded regard VBN cord-021413-1ht1xm88 528 7 as as IN cord-021413-1ht1xm88 528 8 occurring occur VBG cord-021413-1ht1xm88 528 9 worldwide worldwide RB cord-021413-1ht1xm88 528 10 . . . cord-021413-1ht1xm88 529 1 These these DT cord-021413-1ht1xm88 529 2 have have VBP cord-021413-1ht1xm88 529 3 been be VBN cord-021413-1ht1xm88 529 4 defined define VBN cord-021413-1ht1xm88 529 5 as as IN cord-021413-1ht1xm88 529 6 occurring occur VBG cord-021413-1ht1xm88 529 7 more more JJR cord-021413-1ht1xm88 529 8 than than IN cord-021413-1ht1xm88 529 9 2 2 CD cord-021413-1ht1xm88 529 10 months month NNS cord-021413-1ht1xm88 529 11 after after IN cord-021413-1ht1xm88 529 12 intracerebral intracerebral NN cord-021413-1ht1xm88 529 13 , , , cord-021413-1ht1xm88 529 14 intraperitoneal intraperitoneal JJ cord-021413-1ht1xm88 529 15 , , , cord-021413-1ht1xm88 529 16 intranasal intranasal NN cord-021413-1ht1xm88 529 17 , , , cord-021413-1ht1xm88 529 18 or or CC cord-021413-1ht1xm88 529 19 intravenous intravenous JJ cord-021413-1ht1xm88 529 20 inoculation inoculation NN cord-021413-1ht1xm88 529 21 ( ( -LRB- cord-021413-1ht1xm88 529 22 as as IN cord-021413-1ht1xm88 529 23 reviewed review VBN cord-021413-1ht1xm88 529 24 in in IN cord-021413-1ht1xm88 529 25 Robb Robb NNP cord-021413-1ht1xm88 529 26 and and CC cord-021413-1ht1xm88 529 27 Bond Bond NNP cord-021413-1ht1xm88 529 28 , , , cord-021413-1ht1xm88 529 29 1980 1980 CD cord-021413-1ht1xm88 529 30 ) ) -RRB- cord-021413-1ht1xm88 529 31 . . . cord-021413-1ht1xm88 530 1 The the DT cord-021413-1ht1xm88 530 2 chronic chronic JJ cord-021413-1ht1xm88 530 3 clinical clinical JJ cord-021413-1ht1xm88 530 4 manifestations manifestation NNS cord-021413-1ht1xm88 530 5 range range VBP cord-021413-1ht1xm88 530 6 from from IN cord-021413-1ht1xm88 530 7 none none NN cord-021413-1ht1xm88 530 8 to to IN cord-021413-1ht1xm88 530 9 porenceph porenceph NNP cord-021413-1ht1xm88 530 10 aly aly NNP cord-021413-1ht1xm88 530 11 , , , cord-021413-1ht1xm88 530 12 paralysis paralysis NN cord-021413-1ht1xm88 530 13 , , , cord-021413-1ht1xm88 530 14 hepatitis hepatitis NN cord-021413-1ht1xm88 530 15 , , , cord-021413-1ht1xm88 530 16 immunodeficiency immunodeficiency NN cord-021413-1ht1xm88 530 17 manifestations manifestation NNS cord-021413-1ht1xm88 530 18 , , , cord-021413-1ht1xm88 530 19 encephalitis encephalitis RB cord-021413-1ht1xm88 530 20 , , , cord-021413-1ht1xm88 530 21 lymph lymph NN cord-021413-1ht1xm88 530 22 node node NN cord-021413-1ht1xm88 530 23 adenopathy adenopathy NNP cord-021413-1ht1xm88 530 24 , , , cord-021413-1ht1xm88 530 25 and and CC cord-021413-1ht1xm88 530 26 vasculitis vasculitis NN cord-021413-1ht1xm88 530 27 . . . cord-021413-1ht1xm88 531 1 Virus virus NN cord-021413-1ht1xm88 531 2 may may MD cord-021413-1ht1xm88 531 3 or or CC cord-021413-1ht1xm88 531 4 may may MD cord-021413-1ht1xm88 531 5 not not RB cord-021413-1ht1xm88 531 6 be be VB cord-021413-1ht1xm88 531 7 isolated isolate VBN cord-021413-1ht1xm88 531 8 . . . cord-021413-1ht1xm88 532 1 Cells cell NNS cord-021413-1ht1xm88 532 2 stainable stainable JJ cord-021413-1ht1xm88 532 3 by by IN cord-021413-1ht1xm88 532 4 immunofluores immunofluores NNP cord-021413-1ht1xm88 532 5 cence cence NNP cord-021413-1ht1xm88 532 6 may may MD cord-021413-1ht1xm88 532 7 be be VB cord-021413-1ht1xm88 532 8 found find VBN cord-021413-1ht1xm88 532 9 . . . cord-021413-1ht1xm88 533 1 Demyelination Demyelination NNP cord-021413-1ht1xm88 533 2 with with IN cord-021413-1ht1xm88 533 3 or or CC cord-021413-1ht1xm88 533 4 without without IN cord-021413-1ht1xm88 533 5 remyelination remyelination NN cord-021413-1ht1xm88 533 6 may may MD cord-021413-1ht1xm88 533 7 occur occur VB cord-021413-1ht1xm88 533 8 . . . cord-021413-1ht1xm88 534 1 Occasional occasional JJ cord-021413-1ht1xm88 534 2 scattered scatter VBN cord-021413-1ht1xm88 534 3 mononuclear mononuclear JJ cord-021413-1ht1xm88 534 4 cell cell NN cord-021413-1ht1xm88 534 5 infil infil NNP cord-021413-1ht1xm88 534 6 trates trate NNS cord-021413-1ht1xm88 534 7 may may MD cord-021413-1ht1xm88 534 8 be be VB cord-021413-1ht1xm88 534 9 evident evident JJ cord-021413-1ht1xm88 534 10 . . . cord-021413-1ht1xm88 535 1 There there EX cord-021413-1ht1xm88 535 2 is be VBZ cord-021413-1ht1xm88 535 3 no no DT cord-021413-1ht1xm88 535 4 evidence evidence NN cord-021413-1ht1xm88 535 5 that that IN cord-021413-1ht1xm88 535 6 seasonal seasonal JJ cord-021413-1ht1xm88 535 7 changes change NNS cord-021413-1ht1xm88 535 8 influence influence VBP cord-021413-1ht1xm88 535 9 the the DT cord-021413-1ht1xm88 535 10 oc oc NNP cord-021413-1ht1xm88 535 11 currence currence NNP cord-021413-1ht1xm88 535 12 of of IN cord-021413-1ht1xm88 535 13 epizootics epizootic NNS cord-021413-1ht1xm88 535 14 of of IN cord-021413-1ht1xm88 535 15 MHV MHV NNP cord-021413-1ht1xm88 535 16 infection infection NN cord-021413-1ht1xm88 535 17 . . . cord-021413-1ht1xm88 536 1 As as IN cord-021413-1ht1xm88 536 2 indicated indicate VBN cord-021413-1ht1xm88 536 3 above above RB cord-021413-1ht1xm88 536 4 , , , cord-021413-1ht1xm88 536 5 serologic serologic JJ cord-021413-1ht1xm88 536 6 testing testing NN cord-021413-1ht1xm88 536 7 is be VBZ cord-021413-1ht1xm88 536 8 routinely routinely RB cord-021413-1ht1xm88 536 9 carried carry VBN cord-021413-1ht1xm88 536 10 out out RP cord-021413-1ht1xm88 536 11 by by IN cord-021413-1ht1xm88 536 12 means mean NNS cord-021413-1ht1xm88 536 13 of of IN cord-021413-1ht1xm88 536 14 the the DT cord-021413-1ht1xm88 536 15 complement complement NN cord-021413-1ht1xm88 536 16 fixation fixation NN cord-021413-1ht1xm88 536 17 test test NN cord-021413-1ht1xm88 536 18 . . . cord-021413-1ht1xm88 537 1 Cross cros NNS cord-021413-1ht1xm88 537 2 - - NNS cord-021413-1ht1xm88 537 3 reactions reaction NNS cord-021413-1ht1xm88 537 4 with with IN cord-021413-1ht1xm88 537 5 other other JJ cord-021413-1ht1xm88 537 6 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 537 7 must must MD cord-021413-1ht1xm88 537 8 be be VB cord-021413-1ht1xm88 537 9 taken take VBN cord-021413-1ht1xm88 537 10 into into IN cord-021413-1ht1xm88 537 11 account account NN cord-021413-1ht1xm88 537 12 when when WRB cord-021413-1ht1xm88 537 13 inteφreting inteφrete VBG cord-021413-1ht1xm88 537 14 the the DT cord-021413-1ht1xm88 537 15 results result NNS cord-021413-1ht1xm88 537 16 , , , cord-021413-1ht1xm88 537 17 however however RB cord-021413-1ht1xm88 537 18 . . . cord-021413-1ht1xm88 538 1 Neutralization neutralization NN cord-021413-1ht1xm88 538 2 tests test NNS cord-021413-1ht1xm88 538 3 performed perform VBN cord-021413-1ht1xm88 538 4 in in IN cord-021413-1ht1xm88 538 5 tis tis NNP cord-021413-1ht1xm88 538 6 sue sue NNP cord-021413-1ht1xm88 538 7 culture culture NN cord-021413-1ht1xm88 538 8 systems system NNS cord-021413-1ht1xm88 538 9 are be VBP cord-021413-1ht1xm88 538 10 also also RB cord-021413-1ht1xm88 538 11 possible possible JJ cord-021413-1ht1xm88 538 12 . . . cord-021413-1ht1xm88 539 1 Employing employ VBG cord-021413-1ht1xm88 539 2 virus virus NN cord-021413-1ht1xm88 539 3 strain strain NN cord-021413-1ht1xm88 539 4 A59 A59 NNP cord-021413-1ht1xm88 539 5 as as IN cord-021413-1ht1xm88 539 6 antigen antigen NN cord-021413-1ht1xm88 539 7 in in IN cord-021413-1ht1xm88 539 8 the the DT cord-021413-1ht1xm88 539 9 ELISA ELISA NNP cord-021413-1ht1xm88 539 10 , , , cord-021413-1ht1xm88 539 11 Peters Peters NNP cord-021413-1ht1xm88 539 12 et et NNP cord-021413-1ht1xm88 539 13 al al NNP cord-021413-1ht1xm88 539 14 . . . cord-021413-1ht1xm88 540 1 ( ( -LRB- cord-021413-1ht1xm88 540 2 1979 1979 CD cord-021413-1ht1xm88 540 3 ) ) -RRB- cord-021413-1ht1xm88 540 4 found find VBD cord-021413-1ht1xm88 540 5 a a DT cord-021413-1ht1xm88 540 6 high high JJ cord-021413-1ht1xm88 540 7 prevalence prevalence NN cord-021413-1ht1xm88 540 8 of of IN cord-021413-1ht1xm88 540 9 MHV MHV NNP cord-021413-1ht1xm88 540 10 antibodies antibody NNS cord-021413-1ht1xm88 540 11 in in IN cord-021413-1ht1xm88 540 12 colonies colony NNS cord-021413-1ht1xm88 540 13 with with IN cord-021413-1ht1xm88 540 14 a a DT cord-021413-1ht1xm88 540 15 low low JJ cord-021413-1ht1xm88 540 16 incidence incidence NN cord-021413-1ht1xm88 540 17 of of IN cord-021413-1ht1xm88 540 18 both both DT cord-021413-1ht1xm88 540 19 complement complement NN cord-021413-1ht1xm88 540 20 - - HYPH cord-021413-1ht1xm88 540 21 fixing fix VBG cord-021413-1ht1xm88 540 22 and and CC cord-021413-1ht1xm88 540 23 neutralizing neutralize VBG cord-021413-1ht1xm88 540 24 antibodies antibody NNS cord-021413-1ht1xm88 540 25 . . . cord-021413-1ht1xm88 541 1 Hierholzer Hierholzer NNP cord-021413-1ht1xm88 541 2 and and CC cord-021413-1ht1xm88 541 3 Tannock Tannock NNP cord-021413-1ht1xm88 541 4 ( ( -LRB- cord-021413-1ht1xm88 541 5 1977 1977 CD cord-021413-1ht1xm88 541 6 ) ) -RRB- cord-021413-1ht1xm88 541 7 have have VBP cord-021413-1ht1xm88 541 8 used use VBN cord-021413-1ht1xm88 541 9 the the DT cord-021413-1ht1xm88 541 10 single single JJ cord-021413-1ht1xm88 541 11 radial radial JJ cord-021413-1ht1xm88 541 12 hemolysis hemolysis NN cord-021413-1ht1xm88 541 13 test test NN cord-021413-1ht1xm88 541 14 for for IN cord-021413-1ht1xm88 541 15 human human JJ cord-021413-1ht1xm88 541 16 Coronavirus Coronavirus NNP cord-021413-1ht1xm88 541 17 serodiagnosis serodiagnosis NN cord-021413-1ht1xm88 541 18 . . . cord-021413-1ht1xm88 542 1 They -PRON- PRP cord-021413-1ht1xm88 542 2 then then RB cord-021413-1ht1xm88 542 3 applied apply VBD cord-021413-1ht1xm88 542 4 it -PRON- PRP cord-021413-1ht1xm88 542 5 to to IN cord-021413-1ht1xm88 542 6 some some DT cord-021413-1ht1xm88 542 7 MHV MHV NNP cord-021413-1ht1xm88 542 8 strains strain NNS cord-021413-1ht1xm88 542 9 ( ( -LRB- cord-021413-1ht1xm88 542 10 Hierholzer Hierholzer NNP cord-021413-1ht1xm88 542 11 et et NNP cord-021413-1ht1xm88 542 12 aL aL NNP cord-021413-1ht1xm88 542 13 , , , cord-021413-1ht1xm88 542 14 1979 1979 CD cord-021413-1ht1xm88 542 15 ) ) -RRB- cord-021413-1ht1xm88 542 16 . . . cord-021413-1ht1xm88 543 1 These these DT cord-021413-1ht1xm88 543 2 techniques technique NNS cord-021413-1ht1xm88 543 3 are be VBP cord-021413-1ht1xm88 543 4 helpful helpful JJ cord-021413-1ht1xm88 543 5 under under IN cord-021413-1ht1xm88 543 6 certain certain JJ cord-021413-1ht1xm88 543 7 circumstances circumstance NNS cord-021413-1ht1xm88 543 8 , , , cord-021413-1ht1xm88 543 9 e.g. e.g. RB cord-021413-1ht1xm88 543 10 , , , cord-021413-1ht1xm88 543 11 experimental experimental JJ cord-021413-1ht1xm88 543 12 investigations investigation NNS cord-021413-1ht1xm88 543 13 , , , cord-021413-1ht1xm88 543 14 but but CC cord-021413-1ht1xm88 543 15 they -PRON- PRP cord-021413-1ht1xm88 543 16 are be VBP cord-021413-1ht1xm88 543 17 inefficient inefficient JJ cord-021413-1ht1xm88 543 18 for for IN cord-021413-1ht1xm88 543 19 field field NN cord-021413-1ht1xm88 543 20 conditions condition NNS cord-021413-1ht1xm88 543 21 . . . cord-021413-1ht1xm88 544 1 Necropsy necropsy JJ cord-021413-1ht1xm88 544 2 of of IN cord-021413-1ht1xm88 544 3 dead dead JJ cord-021413-1ht1xm88 544 4 or or CC cord-021413-1ht1xm88 544 5 sick sick JJ cord-021413-1ht1xm88 544 6 animals animal NNS cord-021413-1ht1xm88 544 7 is be VBZ cord-021413-1ht1xm88 544 8 always always RB cord-021413-1ht1xm88 544 9 useful useful JJ cord-021413-1ht1xm88 544 10 , , , cord-021413-1ht1xm88 544 11 although although IN cord-021413-1ht1xm88 544 12 a a DT cord-021413-1ht1xm88 544 13 definitive definitive JJ cord-021413-1ht1xm88 544 14 diagnosis diagnosis NN cord-021413-1ht1xm88 544 15 in in IN cord-021413-1ht1xm88 544 16 the the DT cord-021413-1ht1xm88 544 17 absence absence NN cord-021413-1ht1xm88 544 18 of of IN cord-021413-1ht1xm88 544 19 serologic serologic JJ cord-021413-1ht1xm88 544 20 evidence evidence NN cord-021413-1ht1xm88 544 21 can can MD cord-021413-1ht1xm88 544 22 not not RB cord-021413-1ht1xm88 544 23 be be VB cord-021413-1ht1xm88 544 24 made make VBN cord-021413-1ht1xm88 544 25 . . . cord-021413-1ht1xm88 545 1 Nevertheless nevertheless RB cord-021413-1ht1xm88 545 2 , , , cord-021413-1ht1xm88 545 3 wherever wherever WRB cord-021413-1ht1xm88 545 4 possible possible JJ cord-021413-1ht1xm88 545 5 , , , cord-021413-1ht1xm88 545 6 gross gross JJ cord-021413-1ht1xm88 545 7 and and CC cord-021413-1ht1xm88 545 8 microscopic microscopic JJ cord-021413-1ht1xm88 545 9 pathologic pathologic JJ cord-021413-1ht1xm88 545 10 examination examination NN cord-021413-1ht1xm88 545 11 should should MD cord-021413-1ht1xm88 545 12 be be VB cord-021413-1ht1xm88 545 13 undertaken undertake VBN cord-021413-1ht1xm88 545 14 . . . cord-021413-1ht1xm88 546 1 Sentinel sentinel JJ cord-021413-1ht1xm88 546 2 animals animal NNS cord-021413-1ht1xm88 546 3 , , , cord-021413-1ht1xm88 546 4 especially especially RB cord-021413-1ht1xm88 546 5 gnotobiotes gnotobiotes NNP cord-021413-1ht1xm88 546 6 , , , cord-021413-1ht1xm88 546 7 could could MD cord-021413-1ht1xm88 546 8 be be VB cord-021413-1ht1xm88 546 9 Ιηοοφοrated ιηοοφοrate VBN cord-021413-1ht1xm88 546 10 into into IN cord-021413-1ht1xm88 546 11 a a DT cord-021413-1ht1xm88 546 12 program program NN cord-021413-1ht1xm88 546 13 of of IN cord-021413-1ht1xm88 546 14 colony colony NN cord-021413-1ht1xm88 546 15 health health NN cord-021413-1ht1xm88 546 16 surveillance surveillance NN cord-021413-1ht1xm88 546 17 . . . cord-021413-1ht1xm88 547 1 These these DT cord-021413-1ht1xm88 547 2 ani ani NNP cord-021413-1ht1xm88 547 3 mals mal NNS cord-021413-1ht1xm88 547 4 can can MD cord-021413-1ht1xm88 547 5 then then RB cord-021413-1ht1xm88 547 6 be be VB cord-021413-1ht1xm88 547 7 checked check VBN cord-021413-1ht1xm88 547 8 at at IN cord-021413-1ht1xm88 547 9 predetermined predetermine VBN cord-021413-1ht1xm88 547 10 intervals interval NNS cord-021413-1ht1xm88 547 11 for for IN cord-021413-1ht1xm88 547 12 clini clini NNP cord-021413-1ht1xm88 547 13 cal cal NNP cord-021413-1ht1xm88 547 14 , , , cord-021413-1ht1xm88 547 15 serologic serologic NNP cord-021413-1ht1xm88 547 16 , , , cord-021413-1ht1xm88 547 17 and and CC cord-021413-1ht1xm88 547 18 histopathologic histopathologic JJ cord-021413-1ht1xm88 547 19 evidence evidence NN cord-021413-1ht1xm88 547 20 of of IN cord-021413-1ht1xm88 547 21 endemic endemic JJ cord-021413-1ht1xm88 547 22 dis dis NN cord-021413-1ht1xm88 547 23 ease ease NN cord-021413-1ht1xm88 547 24 in in IN cord-021413-1ht1xm88 547 25 the the DT cord-021413-1ht1xm88 547 26 colony colony NN cord-021413-1ht1xm88 547 27 . . . cord-021413-1ht1xm88 548 1 Control control NN cord-021413-1ht1xm88 548 2 of of IN cord-021413-1ht1xm88 548 3 MHV MHV NNP cord-021413-1ht1xm88 548 4 is be VBZ cord-021413-1ht1xm88 548 5 difficult difficult JJ cord-021413-1ht1xm88 548 6 in in IN cord-021413-1ht1xm88 548 7 mouse mouse NN cord-021413-1ht1xm88 548 8 colonies colony NNS cord-021413-1ht1xm88 548 9 unless unless IN cord-021413-1ht1xm88 548 10 caesa caesa NNP cord-021413-1ht1xm88 548 11 rian rian NNP cord-021413-1ht1xm88 548 12 derivation derivation NN cord-021413-1ht1xm88 548 13 coupled couple VBN cord-021413-1ht1xm88 548 14 with with IN cord-021413-1ht1xm88 548 15 barrier barrier NN cord-021413-1ht1xm88 548 16 maintenance maintenance NN cord-021413-1ht1xm88 548 17 is be VBZ cord-021413-1ht1xm88 548 18 under under IN cord-021413-1ht1xm88 548 19 taken take VBN cord-021413-1ht1xm88 548 20 . . . cord-021413-1ht1xm88 549 1 With with IN cord-021413-1ht1xm88 549 2 the the DT cord-021413-1ht1xm88 549 3 finding finding NN cord-021413-1ht1xm88 549 4 that that IN cord-021413-1ht1xm88 549 5 vertical vertical JJ cord-021413-1ht1xm88 549 6 transmission transmission NN cord-021413-1ht1xm88 549 7 is be VBZ cord-021413-1ht1xm88 549 8 possible possible JJ cord-021413-1ht1xm88 549 9 , , , cord-021413-1ht1xm88 549 10 however however RB cord-021413-1ht1xm88 549 11 , , , cord-021413-1ht1xm88 549 12 barrier barrier NN cord-021413-1ht1xm88 549 13 maintenance maintenance NN cord-021413-1ht1xm88 549 14 alone alone RB cord-021413-1ht1xm88 549 15 may may MD cord-021413-1ht1xm88 549 16 not not RB cord-021413-1ht1xm88 549 17 be be VB cord-021413-1ht1xm88 549 18 adequate adequate JJ cord-021413-1ht1xm88 549 19 if if IN cord-021413-1ht1xm88 549 20 , , , cord-021413-1ht1xm88 549 21 for for IN cord-021413-1ht1xm88 549 22 example example NN cord-021413-1ht1xm88 549 23 , , , cord-021413-1ht1xm88 549 24 such such JJ cord-021413-1ht1xm88 549 25 transmission transmission NN cord-021413-1ht1xm88 549 26 is be VBZ cord-021413-1ht1xm88 549 27 frequent frequent JJ cord-021413-1ht1xm88 549 28 . . . cord-021413-1ht1xm88 550 1 Using use VBG cord-021413-1ht1xm88 550 2 small small JJ cord-021413-1ht1xm88 550 3 number number NN cord-021413-1ht1xm88 550 4 of of IN cord-021413-1ht1xm88 550 5 animals animal NNS cord-021413-1ht1xm88 550 6 for for IN cord-021413-1ht1xm88 550 7 experimental experimental JJ cord-021413-1ht1xm88 550 8 puφoses puφose NNS cord-021413-1ht1xm88 550 9 , , , cord-021413-1ht1xm88 550 10 Kraft Kraft NNP cord-021413-1ht1xm88 550 11 ( ( -LRB- cord-021413-1ht1xm88 550 12 1962a 1962a CD cord-021413-1ht1xm88 550 13 ) ) -RRB- cord-021413-1ht1xm88 551 1 Tamura Tamura NNP cord-021413-1ht1xm88 551 2 et et NNP cord-021413-1ht1xm88 551 3 aL aL NNP cord-021413-1ht1xm88 551 4 ( ( -LRB- cord-021413-1ht1xm88 551 5 1976 1976 CD cord-021413-1ht1xm88 551 6 ) ) -RRB- cord-021413-1ht1xm88 551 7 found find VBD cord-021413-1ht1xm88 551 8 that that IN cord-021413-1ht1xm88 551 9 nu nu NNP cord-021413-1ht1xm88 551 10 / / SYM cord-021413-1ht1xm88 551 11 nu nu NNP cord-021413-1ht1xm88 551 12 mice mouse NNS cord-021413-1ht1xm88 551 13 could could MD cord-021413-1ht1xm88 551 14 resist resist VB cord-021413-1ht1xm88 551 15 MHV mhv NN cord-021413-1ht1xm88 551 16 infection infection NN cord-021413-1ht1xm88 551 17 when when WRB cord-021413-1ht1xm88 551 18 they -PRON- PRP cord-021413-1ht1xm88 551 19 previously previously RB cord-021413-1ht1xm88 551 20 received receive VBD cord-021413-1ht1xm88 551 21 thymocytes thymocyte NNS cord-021413-1ht1xm88 551 22 from from IN cord-021413-1ht1xm88 551 23 weanling weanle VBG cord-021413-1ht1xm88 551 24 nu/+ nu/+ CD cord-021413-1ht1xm88 551 25 littermates littermate NNS cord-021413-1ht1xm88 551 26 . . . cord-021413-1ht1xm88 552 1 They -PRON- PRP cord-021413-1ht1xm88 552 2 were be VBD cord-021413-1ht1xm88 552 3 then then RB cord-021413-1ht1xm88 552 4 not not RB cord-021413-1ht1xm88 552 5 only only RB cord-021413-1ht1xm88 552 6 able able JJ cord-021413-1ht1xm88 552 7 to to TO cord-021413-1ht1xm88 552 8 produce produce VB cord-021413-1ht1xm88 552 9 antibody antibody NN cord-021413-1ht1xm88 552 10 but but CC cord-021413-1ht1xm88 552 11 survived survive VBD cord-021413-1ht1xm88 552 12 a a DT cord-021413-1ht1xm88 552 13 challenge challenge NN cord-021413-1ht1xm88 552 14 infection infection NN cord-021413-1ht1xm88 552 15 as as RB cord-021413-1ht1xm88 552 16 well well RB cord-021413-1ht1xm88 552 17 . . . cord-021413-1ht1xm88 553 1 Studies study NNS cord-021413-1ht1xm88 553 2 on on IN cord-021413-1ht1xm88 553 3 rotaviral rotaviral JJ cord-021413-1ht1xm88 553 4 antibody antibody NN cord-021413-1ht1xm88 553 5 in in IN cord-021413-1ht1xm88 553 6 bovine bovine JJ cord-021413-1ht1xm88 553 7 serum serum NN cord-021413-1ht1xm88 553 8 and and CC cord-021413-1ht1xm88 553 9 lacteal lacteal JJ cord-021413-1ht1xm88 553 10 secretions secretion NNS cord-021413-1ht1xm88 553 11 , , , cord-021413-1ht1xm88 553 12 using use VBG cord-021413-1ht1xm88 553 13 radioimmunoassay radioimmunoassay JJ cord-021413-1ht1xm88 553 14 Epidemic epidemic NN cord-021413-1ht1xm88 553 15 diarrhea diarrhea NN cord-021413-1ht1xm88 553 16 of of IN cord-021413-1ht1xm88 553 17 infant infant NN cord-021413-1ht1xm88 553 18 mice mouse NNS cord-021413-1ht1xm88 553 19 . . . cord-021413-1ht1xm88 554 1 Identification identification NN cord-021413-1ht1xm88 554 2 of of IN cord-021413-1ht1xm88 554 3 the the DT cord-021413-1ht1xm88 554 4 etiologic etiologic JJ cord-021413-1ht1xm88 554 5 agent agent NN cord-021413-1ht1xm88 554 6 Electron Electron NNP cord-021413-1ht1xm88 554 7 microscopic microscopic JJ cord-021413-1ht1xm88 554 8 study study NN cord-021413-1ht1xm88 554 9 of of IN cord-021413-1ht1xm88 554 10 the the DT cord-021413-1ht1xm88 554 11 intestinal intestinal JJ cord-021413-1ht1xm88 554 12 epithelium epithelium NN cord-021413-1ht1xm88 554 13 of of IN cord-021413-1ht1xm88 554 14 mice mouse NNS cord-021413-1ht1xm88 554 15 infected infect VBN cord-021413-1ht1xm88 554 16 with with IN cord-021413-1ht1xm88 554 17 the the DT cord-021413-1ht1xm88 554 18 agent agent NN cord-021413-1ht1xm88 554 19 of of IN cord-021413-1ht1xm88 554 20 epizootic epizootic JJ cord-021413-1ht1xm88 554 21 diarrhea diarrhea NN cord-021413-1ht1xm88 554 22 of of IN cord-021413-1ht1xm88 554 23 infant infant NN cord-021413-1ht1xm88 554 24 mice mouse NNS cord-021413-1ht1xm88 554 25 ( ( -LRB- cord-021413-1ht1xm88 554 26 EDIM EDIM NNP cord-021413-1ht1xm88 554 27 virus virus NN cord-021413-1ht1xm88 554 28 ) ) -RRB- cord-021413-1ht1xm88 555 1 The the DT cord-021413-1ht1xm88 555 2 morphology morphology NN cord-021413-1ht1xm88 555 3 of of IN cord-021413-1ht1xm88 555 4 three three CD cord-021413-1ht1xm88 555 5 pre pre NNP cord-021413-1ht1xm88 555 6 viously viously NNP cord-021413-1ht1xm88 555 7 uncharacterized uncharacterized JJ cord-021413-1ht1xm88 555 8 human human JJ cord-021413-1ht1xm88 555 9 respiratory respiratory JJ cord-021413-1ht1xm88 555 10 viruses virus NNS cord-021413-1ht1xm88 555 11 that that WDT cord-021413-1ht1xm88 555 12 grow grow VBP cord-021413-1ht1xm88 555 13 in in IN cord-021413-1ht1xm88 555 14 organ organ NN cord-021413-1ht1xm88 555 15 culture culture NN cord-021413-1ht1xm88 556 1 The the DT cord-021413-1ht1xm88 556 2 effect effect NN cord-021413-1ht1xm88 556 3 of of IN cord-021413-1ht1xm88 556 4 trypsin trypsin NN cord-021413-1ht1xm88 556 5 on on IN cord-021413-1ht1xm88 556 6 the the DT cord-021413-1ht1xm88 556 7 growth growth NN cord-021413-1ht1xm88 556 8 of of IN cord-021413-1ht1xm88 556 9 rotavirus rotavirus JJ cord-021413-1ht1xm88 556 10 Viruses virus NNS cord-021413-1ht1xm88 556 11 of of IN cord-021413-1ht1xm88 556 12 Verte Verte NNP cord-021413-1ht1xm88 556 13 brates brates NNP cord-021413-1ht1xm88 556 14 Panel Panel NNP cord-021413-1ht1xm88 556 15 Report Report NNP cord-021413-1ht1xm88 556 16 of of IN cord-021413-1ht1xm88 556 17 the the DT cord-021413-1ht1xm88 556 18 Colloquium Colloquium NNP cord-021413-1ht1xm88 556 19 on on IN cord-021413-1ht1xm88 556 20 Selected Selected NNP cord-021413-1ht1xm88 556 21 Diarrheal Diarrheal NNP cord-021413-1ht1xm88 556 22 Diseases Diseases NNPS cord-021413-1ht1xm88 556 23 of of IN cord-021413-1ht1xm88 556 24 the the DT cord-021413-1ht1xm88 556 25 Young Young NNP cord-021413-1ht1xm88 556 26 Rotavirus Rotavirus NNP cord-021413-1ht1xm88 556 27 isolation isolation NN cord-021413-1ht1xm88 556 28 and and CC cord-021413-1ht1xm88 556 29 cultivation cultivation NN cord-021413-1ht1xm88 556 30 in in IN cord-021413-1ht1xm88 556 31 the the DT cord-021413-1ht1xm88 556 32 presence presence NN cord-021413-1ht1xm88 556 33 of of IN cord-021413-1ht1xm88 556 34 trypsin trypsin NN cord-021413-1ht1xm88 556 35 A a DT cord-021413-1ht1xm88 556 36 murine murine JJ cord-021413-1ht1xm88 556 37 virus virus NN cord-021413-1ht1xm88 556 38 ( ( -LRB- cord-021413-1ht1xm88 556 39 JHM JHM NNP cord-021413-1ht1xm88 556 40 ) ) -RRB- cord-021413-1ht1xm88 556 41 causing cause VBG cord-021413-1ht1xm88 556 42 disseminated disseminate VBN cord-021413-1ht1xm88 556 43 encephalomyelitis encephalomyelitis NN cord-021413-1ht1xm88 556 44 with with IN cord-021413-1ht1xm88 556 45 extensive extensive JJ cord-021413-1ht1xm88 556 46 destruction destruction NN cord-021413-1ht1xm88 556 47 of of IN cord-021413-1ht1xm88 556 48 myelin myelin NN cord-021413-1ht1xm88 556 49 . . . cord-021413-1ht1xm88 557 1 II II NNP cord-021413-1ht1xm88 558 1 In in IN cord-021413-1ht1xm88 558 2 vitro vitro FW cord-021413-1ht1xm88 558 3 detection detection NN cord-021413-1ht1xm88 558 4 of of IN cord-021413-1ht1xm88 558 5 human human JJ cord-021413-1ht1xm88 558 6 rotaviruses rotaviruses NNP cord-021413-1ht1xm88 558 7 Further Further NNP cord-021413-1ht1xm88 558 8 observa observa NNP cord-021413-1ht1xm88 558 9 tions tion NNS cord-021413-1ht1xm88 558 10 on on IN cord-021413-1ht1xm88 558 11 the the DT cord-021413-1ht1xm88 558 12 virus virus NN cord-021413-1ht1xm88 558 13 of of IN cord-021413-1ht1xm88 558 14 epizootic epizootic JJ cord-021413-1ht1xm88 558 15 diarrhea diarrhea NN cord-021413-1ht1xm88 558 16 of of IN cord-021413-1ht1xm88 558 17 infant infant JJ cord-021413-1ht1xm88 558 18 mice mouse NNS cord-021413-1ht1xm88 558 19 . . . cord-021413-1ht1xm88 559 1 An an DT cord-021413-1ht1xm88 559 2 electron electron NN cord-021413-1ht1xm88 559 3 microscopic microscopic JJ cord-021413-1ht1xm88 559 4 study study NN cord-021413-1ht1xm88 559 5 Genetics genetic NNS cord-021413-1ht1xm88 559 6 of of IN cord-021413-1ht1xm88 559 7 resistance resistance NN cord-021413-1ht1xm88 559 8 of of IN cord-021413-1ht1xm88 559 9 animals animal NNS cord-021413-1ht1xm88 559 10 to to IN cord-021413-1ht1xm88 559 11 viruses virus NNS cord-021413-1ht1xm88 559 12 : : : cord-021413-1ht1xm88 560 1 I. I. NNP cord-021413-1ht1xm88 560 2 Introduc Introduc NNP cord-021413-1ht1xm88 560 3 tion tion NN cord-021413-1ht1xm88 560 4 and and CC cord-021413-1ht1xm88 560 5 studies study NNS cord-021413-1ht1xm88 560 6 in in IN cord-021413-1ht1xm88 560 7 mice mouse NNS cord-021413-1ht1xm88 560 8 Macrophages macrophage NNS cord-021413-1ht1xm88 560 9 and and CC cord-021413-1ht1xm88 560 10 mouse mouse NN cord-021413-1ht1xm88 560 11 hepatitis hepatitis NN cord-021413-1ht1xm88 560 12 Mouse Mouse NNP cord-021413-1ht1xm88 560 13 macrophages macrophage NNS cord-021413-1ht1xm88 560 14 as as IN cord-021413-1ht1xm88 560 15 host host NN cord-021413-1ht1xm88 560 16 cells cell NNS cord-021413-1ht1xm88 560 17 for for IN cord-021413-1ht1xm88 560 18 the the DT cord-021413-1ht1xm88 560 19 mouse mouse NN cord-021413-1ht1xm88 560 20 hepatitis hepatitis NNP cord-021413-1ht1xm88 560 21 virus virus NN cord-021413-1ht1xm88 560 22 and and CC cord-021413-1ht1xm88 560 23 the the DT cord-021413-1ht1xm88 560 24 genetic genetic JJ cord-021413-1ht1xm88 560 25 basis basis NN cord-021413-1ht1xm88 560 26 of of IN cord-021413-1ht1xm88 560 27 their -PRON- PRP$ cord-021413-1ht1xm88 560 28 susceptibility susceptibility NN cord-021413-1ht1xm88 560 29 Virological virological JJ cord-021413-1ht1xm88 560 30 and and CC cord-021413-1ht1xm88 560 31 cytogenetic cytogenetic JJ cord-021413-1ht1xm88 560 32 studies study NNS cord-021413-1ht1xm88 560 33 on on IN cord-021413-1ht1xm88 560 34 the the DT cord-021413-1ht1xm88 560 35 involvement involvement NN cord-021413-1ht1xm88 560 36 of of IN cord-021413-1ht1xm88 560 37 bone bone NN cord-021413-1ht1xm88 560 38 marrow marrow NN cord-021413-1ht1xm88 560 39 of of IN cord-021413-1ht1xm88 560 40 mice mouse NNS cord-021413-1ht1xm88 560 41 in in IN cord-021413-1ht1xm88 560 42 some some DT cord-021413-1ht1xm88 560 43 hepatoencephalotropic hepatoencephalotropic JJ cord-021413-1ht1xm88 560 44 viral viral JJ cord-021413-1ht1xm88 560 45 infections infection NNS cord-021413-1ht1xm88 560 46 Rotavirus Rotavirus NNP cord-021413-1ht1xm88 560 47 serotypes serotype NNS cord-021413-1ht1xm88 560 48 by by IN cord-021413-1ht1xm88 560 49 serum serum NN cord-021413-1ht1xm88 560 50 neutralisation neutralisation NN cord-021413-1ht1xm88 560 51 Moφhogenesis Moφhogenesis NNP cord-021413-1ht1xm88 560 52 of of IN cord-021413-1ht1xm88 560 53 avian avian JJ cord-021413-1ht1xm88 560 54 infectious infectious JJ cord-021413-1ht1xm88 560 55 bronchitis bronchitis NN cord-021413-1ht1xm88 560 56 virus virus NN cord-021413-1ht1xm88 560 57 and and CC cord-021413-1ht1xm88 560 58 a a DT cord-021413-1ht1xm88 560 59 related relate VBN cord-021413-1ht1xm88 560 60 human human JJ cord-021413-1ht1xm88 560 61 virus virus NN cord-021413-1ht1xm88 560 62 ( ( -LRB- cord-021413-1ht1xm88 560 63 Strain strain NN cord-021413-1ht1xm88 560 64 229E 229e CD cord-021413-1ht1xm88 560 65 ) ) -RRB- cord-021413-1ht1xm88 561 1 Preparation preparation NN cord-021413-1ht1xm88 561 2 of of IN cord-021413-1ht1xm88 561 3 type type NN cord-021413-1ht1xm88 561 4 - - HYPH cord-021413-1ht1xm88 561 5 specific specific JJ cord-021413-1ht1xm88 561 6 antisera antisera NN cord-021413-1ht1xm88 561 7 to to IN cord-021413-1ht1xm88 561 8 reoviruses reoviruses NNP cord-021413-1ht1xm88 561 9 Isolation Isolation NNP cord-021413-1ht1xm88 561 10 of of IN cord-021413-1ht1xm88 561 11 a a DT cord-021413-1ht1xm88 561 12 reovirus reovirus NN cord-021413-1ht1xm88 561 13 from from IN cord-021413-1ht1xm88 561 14 a a DT cord-021413-1ht1xm88 561 15 case case NN cord-021413-1ht1xm88 561 16 of of IN cord-021413-1ht1xm88 561 17 Burkitt Burkitt NNP cord-021413-1ht1xm88 561 18 's 's POS cord-021413-1ht1xm88 561 19 lymphoma lymphoma NN cord-021413-1ht1xm88 561 20 Isolation isolation NN cord-021413-1ht1xm88 561 21 of of IN cord-021413-1ht1xm88 561 22 a a DT cord-021413-1ht1xm88 561 23 non non JJ cord-021413-1ht1xm88 561 24 - - JJ cord-021413-1ht1xm88 561 25 pathogenic pathogenic JJ cord-021413-1ht1xm88 561 26 tumour tumour NN cord-021413-1ht1xm88 561 27 - - HYPH cord-021413-1ht1xm88 561 28 destroying destroy VBG cord-021413-1ht1xm88 561 29 virus virus NN cord-021413-1ht1xm88 561 30 from from IN cord-021413-1ht1xm88 561 31 mouse mouse NN cord-021413-1ht1xm88 561 32 ascites ascites NN cord-021413-1ht1xm88 561 33 Characteristics characteristic NNS cord-021413-1ht1xm88 561 34 of of IN cord-021413-1ht1xm88 561 35 a a DT cord-021413-1ht1xm88 561 36 newborn newborn JJ cord-021413-1ht1xm88 561 37 runt runt NN cord-021413-1ht1xm88 561 38 disease disease NN cord-021413-1ht1xm88 561 39 induced induce VBN cord-021413-1ht1xm88 561 40 by by IN cord-021413-1ht1xm88 561 41 neonatal neonatal JJ cord-021413-1ht1xm88 561 42 infection infection NN cord-021413-1ht1xm88 561 43 with with IN cord-021413-1ht1xm88 561 44 an an DT cord-021413-1ht1xm88 561 45 oncolytic oncolytic JJ cord-021413-1ht1xm88 561 46 strain strain NN cord-021413-1ht1xm88 561 47 of of IN cord-021413-1ht1xm88 561 48 reovirus reovirus NNP cord-021413-1ht1xm88 561 49 type type NNP cord-021413-1ht1xm88 561 50 3 3 NNP cord-021413-1ht1xm88 561 51 ( ( -LRB- cord-021413-1ht1xm88 561 52 reo3MH reo3MH NNP cord-021413-1ht1xm88 561 53 ) ) -RRB- cord-021413-1ht1xm88 561 54 . . . cord-021413-1ht1xm88 562 1 II II NNP cord-021413-1ht1xm88 562 2 . . . cord-021413-1ht1xm88 563 1 Immunological immunological JJ cord-021413-1ht1xm88 563 2 aspects aspect NNS cord-021413-1ht1xm88 563 3 of of IN cord-021413-1ht1xm88 563 4 the the DT cord-021413-1ht1xm88 563 5 disease disease NN cord-021413-1ht1xm88 563 6 in in IN cord-021413-1ht1xm88 563 7 mice mice NN cord-021413-1ht1xm88 563 8 Characteristics characteristic NNS cord-021413-1ht1xm88 563 9 of of IN cord-021413-1ht1xm88 563 10 a a DT cord-021413-1ht1xm88 563 11 newborn newborn JJ cord-021413-1ht1xm88 563 12 runt runt NN cord-021413-1ht1xm88 563 13 disease disease NN cord-021413-1ht1xm88 563 14 induced induce VBN cord-021413-1ht1xm88 563 15 by by IN cord-021413-1ht1xm88 563 16 neonatal neonatal JJ cord-021413-1ht1xm88 563 17 infection infection NN cord-021413-1ht1xm88 563 18 with with IN cord-021413-1ht1xm88 563 19 an an DT cord-021413-1ht1xm88 563 20 oncolytic oncolytic JJ cord-021413-1ht1xm88 563 21 strain strain NN cord-021413-1ht1xm88 563 22 of of IN cord-021413-1ht1xm88 563 23 reovirus reovirus NNP cord-021413-1ht1xm88 563 24 type type NNP cord-021413-1ht1xm88 563 25 3 3 NNP cord-021413-1ht1xm88 563 26 ( ( -LRB- cord-021413-1ht1xm88 563 27 reo3MH reo3MH NNP cord-021413-1ht1xm88 563 28 ) ) -RRB- cord-021413-1ht1xm88 563 29 . . . cord-021413-1ht1xm88 564 1 I. I. NNP cord-021413-1ht1xm88 564 2 Pathological pathological JJ cord-021413-1ht1xm88 564 3 investigations investigation NNS cord-021413-1ht1xm88 564 4 in in IN cord-021413-1ht1xm88 564 5 rats rat NNS cord-021413-1ht1xm88 564 6 and and CC cord-021413-1ht1xm88 564 7 mice mouse NNS cord-021413-1ht1xm88 564 8 Characterization characterization NN cord-021413-1ht1xm88 564 9 of of IN cord-021413-1ht1xm88 564 10 the the DT cord-021413-1ht1xm88 564 11 virus virus NN cord-021413-1ht1xm88 564 12 of of IN cord-021413-1ht1xm88 564 13 sialodacryoadenitis sialodacryoadenitis NN cord-021413-1ht1xm88 564 14 of of IN cord-021413-1ht1xm88 564 15 rats rat NNS cord-021413-1ht1xm88 564 16 : : : cord-021413-1ht1xm88 564 17 A a DT cord-021413-1ht1xm88 564 18 member member NN cord-021413-1ht1xm88 564 19 of of IN cord-021413-1ht1xm88 564 20 the the DT cord-021413-1ht1xm88 564 21 Coronavirus Coronavirus NNP cord-021413-1ht1xm88 564 22 group group NN cord-021413-1ht1xm88 564 23 Lymphoid lymphoid JJ cord-021413-1ht1xm88 564 24 necrosis necrosis NN cord-021413-1ht1xm88 564 25 in in IN cord-021413-1ht1xm88 564 26 the the DT cord-021413-1ht1xm88 564 27 mouse mouse NN cord-021413-1ht1xm88 564 28 spleen spleen NNS cord-021413-1ht1xm88 564 29 produced produce VBN cord-021413-1ht1xm88 564 30 by by IN cord-021413-1ht1xm88 564 31 mouse mouse NNP cord-021413-1ht1xm88 564 32 hepatitis hepatitis NNP cord-021413-1ht1xm88 564 33 virus virus NN cord-021413-1ht1xm88 564 34 ( ( -LRB- cord-021413-1ht1xm88 564 35 MHV3 MHV3 NNP cord-021413-1ht1xm88 564 36 ) ) -RRB- cord-021413-1ht1xm88 564 37 : : : cord-021413-1ht1xm88 565 1 An an DT cord-021413-1ht1xm88 565 2 electronmicroscopic electronmicroscopic JJ cord-021413-1ht1xm88 565 3 study study NN cord-021413-1ht1xm88 565 4 Lethal lethal JJ cord-021413-1ht1xm88 565 5 intestinal intestinal JJ cord-021413-1ht1xm88 565 6 virus virus NN cord-021413-1ht1xm88 565 7 infection infection NN cord-021413-1ht1xm88 565 8 of of IN cord-021413-1ht1xm88 565 9 mice mouse NNS cord-021413-1ht1xm88 565 10 ( ( -LRB- cord-021413-1ht1xm88 565 11 LIVIM LIVIM NNP cord-021413-1ht1xm88 565 12 ) ) -RRB- cord-021413-1ht1xm88 565 13 . . . cord-021413-1ht1xm88 566 1 An an DT cord-021413-1ht1xm88 566 2 important important JJ cord-021413-1ht1xm88 566 3 new new JJ cord-021413-1ht1xm88 566 4 model model NN cord-021413-1ht1xm88 566 5 for for IN cord-021413-1ht1xm88 566 6 study study NN cord-021413-1ht1xm88 566 7 of of IN cord-021413-1ht1xm88 566 8 the the DT cord-021413-1ht1xm88 566 9 response response NN cord-021413-1ht1xm88 566 10 of of IN cord-021413-1ht1xm88 566 11 the the DT cord-021413-1ht1xm88 566 12 intestinal intestinal JJ cord-021413-1ht1xm88 566 13 mucosa mucosa NN cord-021413-1ht1xm88 566 14 to to TO cord-021413-1ht1xm88 566 15 injury injury NN cord-021413-1ht1xm88 566 16 Virus virus NN cord-021413-1ht1xm88 566 17 particles particle NNS cord-021413-1ht1xm88 566 18 in in IN cord-021413-1ht1xm88 566 19 epithelial epithelial JJ cord-021413-1ht1xm88 566 20 cells cell NNS cord-021413-1ht1xm88 566 21 of of IN cord-021413-1ht1xm88 566 22 duodenal duodenal JJ cord-021413-1ht1xm88 566 23 mucosa mucosa NN cord-021413-1ht1xm88 566 24 from from IN cord-021413-1ht1xm88 566 25 children child NNS cord-021413-1ht1xm88 566 26 with with IN cord-021413-1ht1xm88 566 27 acute acute JJ cord-021413-1ht1xm88 566 28 non non JJ cord-021413-1ht1xm88 566 29 - - JJ cord-021413-1ht1xm88 566 30 bacterial bacterial JJ cord-021413-1ht1xm88 566 31 gastroenteritis gastroenteritis NN cord-021413-1ht1xm88 566 32 Serological serological JJ cord-021413-1ht1xm88 566 33 studies study NNS cord-021413-1ht1xm88 566 34 with with IN cord-021413-1ht1xm88 566 35 an an DT cord-021413-1ht1xm88 566 36 agent agent NN cord-021413-1ht1xm88 566 37 of of IN cord-021413-1ht1xm88 566 38 epizootic epizootic JJ cord-021413-1ht1xm88 566 39 diarrhea diarrhea NN cord-021413-1ht1xm88 566 40 of of IN cord-021413-1ht1xm88 566 41 infant infant NN cord-021413-1ht1xm88 566 42 mice mouse NNS cord-021413-1ht1xm88 566 43 Pathogenic pathogenic JJ cord-021413-1ht1xm88 566 44 murine murine JJ cord-021413-1ht1xm88 566 45 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 566 46 . . . cord-021413-1ht1xm88 567 1 II II NNP cord-021413-1ht1xm88 567 2 . . . cord-021413-1ht1xm88 568 1 Characterization characterization NN cord-021413-1ht1xm88 568 2 of of IN cord-021413-1ht1xm88 568 3 virus virus NN cord-021413-1ht1xm88 568 4 - - HYPH cord-021413-1ht1xm88 568 5 specific specific JJ cord-021413-1ht1xm88 568 6 proteins protein NNS cord-021413-1ht1xm88 568 7 of of IN cord-021413-1ht1xm88 568 8 murine murine JJ cord-021413-1ht1xm88 568 9 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 568 10 JHMV JHMV NNP cord-021413-1ht1xm88 568 11 and and CC cord-021413-1ht1xm88 568 12 A59V A59V NNP cord-021413-1ht1xm88 568 13 Specific specific JJ cord-021413-1ht1xm88 568 14 monovalent monovalent NN cord-021413-1ht1xm88 568 15 cation cation NN cord-021413-1ht1xm88 568 16 effects effect NNS cord-021413-1ht1xm88 568 17 on on IN cord-021413-1ht1xm88 568 18 modification modification NN cord-021413-1ht1xm88 568 19 of of IN cord-021413-1ht1xm88 568 20 reovirus reovirus JJ cord-021413-1ht1xm88 568 21 infectivity infectivity NN cord-021413-1ht1xm88 568 22 by by IN cord-021413-1ht1xm88 568 23 chymotrypsin chymotrypsin JJ cord-021413-1ht1xm88 568 24 digestion digestion NN cord-021413-1ht1xm88 568 25 in in IN cord-021413-1ht1xm88 568 26 vitro vitro FW cord-021413-1ht1xm88 568 27 Ex ex NN cord-021413-1ht1xm88 568 28 traordinary traordinary JJ cord-021413-1ht1xm88 568 29 effects effect NNS cord-021413-1ht1xm88 568 30 of of IN cord-021413-1ht1xm88 568 31 specific specific JJ cord-021413-1ht1xm88 568 32 monovalent monovalent JJ cord-021413-1ht1xm88 568 33 cations cation NNS cord-021413-1ht1xm88 568 34 on on IN cord-021413-1ht1xm88 568 35 activation activation NN cord-021413-1ht1xm88 568 36 of of IN cord-021413-1ht1xm88 568 37 reovirus reovirus NNP cord-021413-1ht1xm88 568 38 transcriptase transcriptase NNP cord-021413-1ht1xm88 568 39 by by IN cord-021413-1ht1xm88 568 40 chymotrypsin chymotrypsin NNP cord-021413-1ht1xm88 568 41 in in IN cord-021413-1ht1xm88 568 42 vitro vitro FW cord-021413-1ht1xm88 568 43 New new JJ cord-021413-1ht1xm88 568 44 intermediate intermediate JJ cord-021413-1ht1xm88 568 45 subviral subviral JJ cord-021413-1ht1xm88 568 46 particles particle NNS cord-021413-1ht1xm88 568 47 in in IN cord-021413-1ht1xm88 568 48 the the DT cord-021413-1ht1xm88 568 49 in in FW cord-021413-1ht1xm88 568 50 vitro vitro FW cord-021413-1ht1xm88 568 51 uncoating uncoating NN cord-021413-1ht1xm88 568 52 of of IN cord-021413-1ht1xm88 568 53 reovirus reovirus NNP cord-021413-1ht1xm88 568 54 virions virion NNS cord-021413-1ht1xm88 568 55 by by IN cord-021413-1ht1xm88 568 56 chymotrypsin chymotrypsin NNP cord-021413-1ht1xm88 568 57 Reovirus Reovirus NNP cord-021413-1ht1xm88 568 58 transcriptase transcriptase NN cord-021413-1ht1xm88 568 59 activation activation NN cord-021413-1ht1xm88 568 60 in in IN cord-021413-1ht1xm88 568 61 vitro vitro FW cord-021413-1ht1xm88 568 62 : : : cord-021413-1ht1xm88 568 63 involvement involvement NN cord-021413-1ht1xm88 568 64 of of IN cord-021413-1ht1xm88 568 65 an an DT cord-021413-1ht1xm88 568 66 endogenous endogenous JJ cord-021413-1ht1xm88 568 67 uncoating uncoating NN cord-021413-1ht1xm88 568 68 activity activity NN cord-021413-1ht1xm88 568 69 in in IN cord-021413-1ht1xm88 568 70 the the DT cord-021413-1ht1xm88 568 71 second second JJ cord-021413-1ht1xm88 568 72 stage stage NN cord-021413-1ht1xm88 568 73 of of IN cord-021413-1ht1xm88 568 74 the the DT cord-021413-1ht1xm88 568 75 process process NN cord-021413-1ht1xm88 568 76 Two two CD cord-021413-1ht1xm88 568 77 modes mode NNS cord-021413-1ht1xm88 568 78 of of IN cord-021413-1ht1xm88 568 79 entry entry NN cord-021413-1ht1xm88 568 80 of of IN cord-021413-1ht1xm88 568 81 reovirus reovirus NNP cord-021413-1ht1xm88 568 82 particles particle NNS cord-021413-1ht1xm88 568 83 into into IN cord-021413-1ht1xm88 568 84 L l NN cord-021413-1ht1xm88 568 85 cells cell NNS cord-021413-1ht1xm88 568 86 Hepatic hepatic JJ cord-021413-1ht1xm88 568 87 localization localization NN cord-021413-1ht1xm88 568 88 of of IN cord-021413-1ht1xm88 568 89 infectious infectious JJ cord-021413-1ht1xm88 568 90 agent agent NN cord-021413-1ht1xm88 568 91 in in IN cord-021413-1ht1xm88 568 92 murine murine JJ cord-021413-1ht1xm88 568 93 viral viral JJ cord-021413-1ht1xm88 568 94 hepatitis hepatitis NN cord-021413-1ht1xm88 568 95 Antigenic antigenic JJ cord-021413-1ht1xm88 568 96 relationships relationship NNS cord-021413-1ht1xm88 568 97 amongst amongst IN cord-021413-1ht1xm88 568 98 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 569 1 A a DT cord-021413-1ht1xm88 569 2 solid solid JJ cord-021413-1ht1xm88 569 3 - - HYPH cord-021413-1ht1xm88 569 4 phase phase NN cord-021413-1ht1xm88 569 5 system system NN cord-021413-1ht1xm88 569 6 ( ( -LRB- cord-021413-1ht1xm88 569 7 SPACE space NN cord-021413-1ht1xm88 569 8 ) ) -RRB- cord-021413-1ht1xm88 569 9 for for IN cord-021413-1ht1xm88 569 10 the the DT cord-021413-1ht1xm88 569 11 detection detection NN cord-021413-1ht1xm88 569 12 and and CC cord-021413-1ht1xm88 569 13 quantification quantification NN cord-021413-1ht1xm88 569 14 of of IN cord-021413-1ht1xm88 569 15 rotavirus rotavirus NN cord-021413-1ht1xm88 569 16 in in IN cord-021413-1ht1xm88 569 17 faeces faece NNS cord-021413-1ht1xm88 569 18 Small small JJ cord-021413-1ht1xm88 569 19 intestinal intestinal JJ cord-021413-1ht1xm88 569 20 epithelial epithelial JJ cord-021413-1ht1xm88 569 21 brush brush NN cord-021413-1ht1xm88 569 22 border border NN cord-021413-1ht1xm88 569 23 enzymatic enzymatic JJ cord-021413-1ht1xm88 569 24 changes change NNS cord-021413-1ht1xm88 569 25 in in IN cord-021413-1ht1xm88 569 26 suckling suckle VBG cord-021413-1ht1xm88 569 27 mice mouse NNS cord-021413-1ht1xm88 569 28 infected infect VBN cord-021413-1ht1xm88 569 29 with with IN cord-021413-1ht1xm88 569 30 reovirus reovirus NNP cord-021413-1ht1xm88 569 31 type type NN cord-021413-1ht1xm88 569 32 3 3 CD cord-021413-1ht1xm88 569 33 Reovirus Reovirus NNP cord-021413-1ht1xm88 569 34 type type NN cord-021413-1ht1xm88 569 35 3 3 CD cord-021413-1ht1xm88 569 36 infection infection NN cord-021413-1ht1xm88 569 37 in in IN cord-021413-1ht1xm88 569 38 a a DT cord-021413-1ht1xm88 569 39 suckling suckle VBG cord-021413-1ht1xm88 569 40 mouse mouse NN cord-021413-1ht1xm88 569 41 : : : cord-021413-1ht1xm88 569 42 the the DT cord-021413-1ht1xm88 569 43 effects effect NNS cord-021413-1ht1xm88 569 44 on on IN cord-021413-1ht1xm88 569 45 pancreatic pancreatic JJ cord-021413-1ht1xm88 569 46 structure structure NN cord-021413-1ht1xm88 569 47 and and CC cord-021413-1ht1xm88 569 48 enzyme enzyme NN cord-021413-1ht1xm88 569 49 content content NN cord-021413-1ht1xm88 569 50 Viral Viral NNP cord-021413-1ht1xm88 569 51 hepatitis hepatitis NN cord-021413-1ht1xm88 569 52 associated associate VBN cord-021413-1ht1xm88 569 53 with with IN cord-021413-1ht1xm88 569 54 trans trans NNP cord-021413-1ht1xm88 569 55 plantable plantable NNP cord-021413-1ht1xm88 569 56 mouse mouse NN cord-021413-1ht1xm88 569 57 leukemia leukemia NN cord-021413-1ht1xm88 569 58 . . . cord-021413-1ht1xm88 570 1 I. I. NNP cord-021413-1ht1xm88 570 2 Acute acute JJ cord-021413-1ht1xm88 570 3 hepatic hepatic JJ cord-021413-1ht1xm88 570 4 manifestations manifestation NNS cord-021413-1ht1xm88 570 5 following follow VBG cord-021413-1ht1xm88 570 6 treatment treatment NN cord-021413-1ht1xm88 570 7 with with IN cord-021413-1ht1xm88 570 8 urethane urethane NN cord-021413-1ht1xm88 570 9 or or CC cord-021413-1ht1xm88 570 10 methylformamide methylformamide JJ cord-021413-1ht1xm88 570 11 Neonatal neonatal JJ cord-021413-1ht1xm88 570 12 calf calf NN cord-021413-1ht1xm88 570 13 diarrhoea diarrhoea NN cord-021413-1ht1xm88 570 14 : : : cord-021413-1ht1xm88 570 15 identifica identifica NNP cord-021413-1ht1xm88 570 16 tion tion NNP cord-021413-1ht1xm88 570 17 of of IN cord-021413-1ht1xm88 570 18 reovirus reovirus NNP cord-021413-1ht1xm88 570 19 - - HYPH cord-021413-1ht1xm88 570 20 like like JJ cord-021413-1ht1xm88 570 21 ( ( -LRB- cord-021413-1ht1xm88 570 22 rotavirus rotavirus NN cord-021413-1ht1xm88 570 23 ) ) -RRB- cord-021413-1ht1xm88 570 24 agent agent NN cord-021413-1ht1xm88 570 25 in in IN cord-021413-1ht1xm88 570 26 faeces faece NNS cord-021413-1ht1xm88 570 27 by by IN cord-021413-1ht1xm88 570 28 immunofluorescence immunofluorescence NN cord-021413-1ht1xm88 570 29 and and CC cord-021413-1ht1xm88 570 30 immune immune JJ cord-021413-1ht1xm88 570 31 electron electron NN cord-021413-1ht1xm88 570 32 microscopy microscopy NN cord-021413-1ht1xm88 571 1 Lethal lethal JJ cord-021413-1ht1xm88 572 1 en en IN cord-021413-1ht1xm88 572 2 teritis teritis NNP cord-021413-1ht1xm88 572 3 in in IN cord-021413-1ht1xm88 572 4 infant infant NN cord-021413-1ht1xm88 572 5 mice mouse NNS cord-021413-1ht1xm88 572 6 caused cause VBN cord-021413-1ht1xm88 572 7 by by IN cord-021413-1ht1xm88 572 8 mouse mouse NNP cord-021413-1ht1xm88 572 9 hepatitis hepatitis NNP cord-021413-1ht1xm88 572 10 virus virus NN cord-021413-1ht1xm88 573 1 The the DT cord-021413-1ht1xm88 573 2 laboratory laboratory NN cord-021413-1ht1xm88 573 3 diagnosis diagnosis NN cord-021413-1ht1xm88 573 4 of of IN cord-021413-1ht1xm88 573 5 epizoo epizoo NNP cord-021413-1ht1xm88 573 6 tic tic NNP cord-021413-1ht1xm88 573 7 diarrhoea diarrhoea NNP cord-021413-1ht1xm88 573 8 of of IN cord-021413-1ht1xm88 573 9 infant infant NN cord-021413-1ht1xm88 573 10 mice mouse NNS cord-021413-1ht1xm88 574 1 A a DT cord-021413-1ht1xm88 574 2 rabbit rabbit NN cord-021413-1ht1xm88 574 3 rotavirus rotavirus NN cord-021413-1ht1xm88 574 4 . . . cord-021413-1ht1xm88 575 1 Vet Vet NNP cord-021413-1ht1xm88 575 2 . . . cord-021413-1ht1xm88 576 1 Ree Ree NNP cord-021413-1ht1xm88 576 2 . . . cord-021413-1ht1xm88 577 1 99 99 CD cord-021413-1ht1xm88 577 2 Diagnosis diagnosis NN cord-021413-1ht1xm88 577 3 of of IN cord-021413-1ht1xm88 577 4 rotavirus rotavirus JJ cord-021413-1ht1xm88 577 5 infection infection NN cord-021413-1ht1xm88 577 6 by by IN cord-021413-1ht1xm88 577 7 cell cell NN cord-021413-1ht1xm88 577 8 culture culture NN cord-021413-1ht1xm88 578 1 A a DT cord-021413-1ht1xm88 578 2 Hepatitis Hepatitis NNP cord-021413-1ht1xm88 578 3 Virus Virus NNP cord-021413-1ht1xm88 578 4 of of IN cord-021413-1ht1xm88 578 5 Mice Mice NNP cord-021413-1ht1xm88 578 6 Two two CD cord-021413-1ht1xm88 578 7 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 578 8 isolated isolate VBN cord-021413-1ht1xm88 578 9 from from IN cord-021413-1ht1xm88 578 10 central central JJ cord-021413-1ht1xm88 578 11 nervous nervous JJ cord-021413-1ht1xm88 578 12 system system NN cord-021413-1ht1xm88 578 13 tissue tissue NN cord-021413-1ht1xm88 578 14 of of IN cord-021413-1ht1xm88 578 15 two two CD cord-021413-1ht1xm88 578 16 multi multi JJ cord-021413-1ht1xm88 578 17 ple ple NN cord-021413-1ht1xm88 578 18 sclerosis sclerosis NN cord-021413-1ht1xm88 578 19 patients patient NNS cord-021413-1ht1xm88 578 20 Mouse Mouse NNP cord-021413-1ht1xm88 578 21 hepatitis hepatitis NN cord-021413-1ht1xm88 578 22 , , , cord-021413-1ht1xm88 579 1 reo-3 reo-3 NNP cord-021413-1ht1xm88 579 2 , , , cord-021413-1ht1xm88 579 3 and and CC cord-021413-1ht1xm88 579 4 the the DT cord-021413-1ht1xm88 579 5 Theiler Theiler NNP cord-021413-1ht1xm88 579 6 viruses virus NNS cord-021413-1ht1xm88 579 7 Activated activate VBN cord-021413-1ht1xm88 579 8 macrophages macrophage NNS cord-021413-1ht1xm88 579 9 in in IN cord-021413-1ht1xm88 579 10 congenitally congenitally RB cord-021413-1ht1xm88 579 11 athymic athymic JJ cord-021413-1ht1xm88 579 12 " " `` cord-021413-1ht1xm88 579 13 nude nude JJ cord-021413-1ht1xm88 579 14 " " '' cord-021413-1ht1xm88 579 15 mice mouse NNS cord-021413-1ht1xm88 579 16 and and CC cord-021413-1ht1xm88 579 17 in in IN cord-021413-1ht1xm88 579 18 lethally lethally RB cord-021413-1ht1xm88 579 19 irradiated irradiate VBN cord-021413-1ht1xm88 579 20 mice mouse NNS cord-021413-1ht1xm88 580 1 Epidemic epidemic NN cord-021413-1ht1xm88 580 2 diarrheal diarrheal JJ cord-021413-1ht1xm88 580 3 disease disease NN cord-021413-1ht1xm88 580 4 of of IN cord-021413-1ht1xm88 580 5 suckling suckle VBG cord-021413-1ht1xm88 580 6 mice mouse NNS cord-021413-1ht1xm88 580 7 Epidemic epidemic NN cord-021413-1ht1xm88 580 8 diarrheal diarrheal JJ cord-021413-1ht1xm88 580 9 disease disease NN cord-021413-1ht1xm88 580 10 of of IN cord-021413-1ht1xm88 580 11 suckling suckle VBG cord-021413-1ht1xm88 580 12 mice mouse NNS cord-021413-1ht1xm88 580 13 . . . cord-021413-1ht1xm88 581 1 I. I. NNP cord-021413-1ht1xm88 581 2 Manifestations manifestation NNS cord-021413-1ht1xm88 581 3 , , , cord-021413-1ht1xm88 581 4 epidemiology epidemiology NN cord-021413-1ht1xm88 581 5 , , , cord-021413-1ht1xm88 581 6 and and CC cord-021413-1ht1xm88 581 7 attempts attempt VBZ cord-021413-1ht1xm88 581 8 to to TO cord-021413-1ht1xm88 581 9 trans trans NNP cord-021413-1ht1xm88 581 10 mit mit NNP cord-021413-1ht1xm88 581 11 the the DT cord-021413-1ht1xm88 581 12 disease disease NN cord-021413-1ht1xm88 581 13 Epidemic Epidemic NNP cord-021413-1ht1xm88 581 14 diarrheal diarrheal JJ cord-021413-1ht1xm88 581 15 disease disease NN cord-021413-1ht1xm88 581 16 of of IN cord-021413-1ht1xm88 581 17 suckling suckle VBG cord-021413-1ht1xm88 581 18 mice mouse NNS cord-021413-1ht1xm88 581 19 . . . cord-021413-1ht1xm88 582 1 III III NNP cord-021413-1ht1xm88 582 2 . . . cord-021413-1ht1xm88 583 1 The the DT cord-021413-1ht1xm88 583 2 effect effect NN cord-021413-1ht1xm88 583 3 of of IN cord-021413-1ht1xm88 583 4 strain strain NN cord-021413-1ht1xm88 583 5 , , , cord-021413-1ht1xm88 583 6 litter litter NN cord-021413-1ht1xm88 583 7 , , , cord-021413-1ht1xm88 583 8 and and CC cord-021413-1ht1xm88 583 9 season season NN cord-021413-1ht1xm88 583 10 upon upon IN cord-021413-1ht1xm88 583 11 the the DT cord-021413-1ht1xm88 583 12 incidence incidence NN cord-021413-1ht1xm88 583 13 of of IN cord-021413-1ht1xm88 583 14 the the DT cord-021413-1ht1xm88 583 15 disease disease NN cord-021413-1ht1xm88 583 16 A A NNP cord-021413-1ht1xm88 583 17 murine murine JJ cord-021413-1ht1xm88 583 18 virus virus NN cord-021413-1ht1xm88 583 19 ( ( -LRB- cord-021413-1ht1xm88 583 20 JHM JHM NNP cord-021413-1ht1xm88 583 21 ) ) -RRB- cord-021413-1ht1xm88 583 22 causing cause VBG cord-021413-1ht1xm88 583 23 disseminated disseminate VBN cord-021413-1ht1xm88 583 24 encephalomyelitis encephalomyelitis NN cord-021413-1ht1xm88 583 25 with with IN cord-021413-1ht1xm88 583 26 extensive extensive JJ cord-021413-1ht1xm88 583 27 destruction destruction NN cord-021413-1ht1xm88 583 28 of of IN cord-021413-1ht1xm88 583 29 myelin myelin NN cord-021413-1ht1xm88 583 30 . . . cord-021413-1ht1xm88 584 1 I. I. NNP cord-021413-1ht1xm88 584 2 Isolation isolation NN cord-021413-1ht1xm88 584 3 and and CC cord-021413-1ht1xm88 584 4 biological biological JJ cord-021413-1ht1xm88 584 5 prop prop NN cord-021413-1ht1xm88 584 6 erties ertie NNS cord-021413-1ht1xm88 584 7 of of IN cord-021413-1ht1xm88 584 8 the the DT cord-021413-1ht1xm88 584 9 virus virus NN cord-021413-1ht1xm88 585 1 Serological serological JJ cord-021413-1ht1xm88 585 2 inter inter JJ cord-021413-1ht1xm88 585 3 relationships relationship NNS cord-021413-1ht1xm88 585 4 of of IN cord-021413-1ht1xm88 585 5 murine murine JJ cord-021413-1ht1xm88 585 6 hepatitis hepatitis NN cord-021413-1ht1xm88 585 7 viruses virus NNS cord-021413-1ht1xm88 585 8 Production production NN cord-021413-1ht1xm88 585 9 of of IN cord-021413-1ht1xm88 585 10 high high JJ cord-021413-1ht1xm88 585 11 - - HYPH cord-021413-1ht1xm88 585 12 titer titer NN cord-021413-1ht1xm88 585 13 bovine bovine JJ cord-021413-1ht1xm88 585 14 rotavirus rotavirus NN cord-021413-1ht1xm88 585 15 with with IN cord-021413-1ht1xm88 585 16 trypsin trypsin NN cord-021413-1ht1xm88 585 17 Murine murine JJ cord-021413-1ht1xm88 585 18 virus virus NN cord-021413-1ht1xm88 585 19 contaminants contaminant NNS cord-021413-1ht1xm88 585 20 of of IN cord-021413-1ht1xm88 585 21 leukemia leukemia NN cord-021413-1ht1xm88 585 22 viruses virus NNS cord-021413-1ht1xm88 585 23 and and CC cord-021413-1ht1xm88 586 1 transplantable transplantable JJ cord-021413-1ht1xm88 586 2 tumors tumor NNS cord-021413-1ht1xm88 586 3 Reovirus Reovirus NNP cord-021413-1ht1xm88 586 4 type type NN cord-021413-1ht1xm88 586 5 3 3 CD cord-021413-1ht1xm88 586 6 infection infection NN cord-021413-1ht1xm88 586 7 in in IN cord-021413-1ht1xm88 586 8 laboratory laboratory NN cord-021413-1ht1xm88 586 9 mice mice NN cord-021413-1ht1xm88 586 10 Temperature temperature NN cord-021413-1ht1xm88 586 11 - - HYPH cord-021413-1ht1xm88 586 12 sensitive sensitive JJ cord-021413-1ht1xm88 586 13 mutants mutant NNS cord-021413-1ht1xm88 586 14 of of IN cord-021413-1ht1xm88 586 15 reovirus reovirus NNP cord-021413-1ht1xm88 586 16 type type NNP cord-021413-1ht1xm88 586 17 3 3 CD cord-021413-1ht1xm88 586 18 : : : cord-021413-1ht1xm88 587 1 Studies study NNS cord-021413-1ht1xm88 587 2 on on IN cord-021413-1ht1xm88 587 3 the the DT cord-021413-1ht1xm88 587 4 synthesis synthesis NN cord-021413-1ht1xm88 587 5 of of IN cord-021413-1ht1xm88 587 6 viral viral JJ cord-021413-1ht1xm88 587 7 RNA RNA NNP cord-021413-1ht1xm88 587 8 Effect Effect NNP cord-021413-1ht1xm88 587 9 of of IN cord-021413-1ht1xm88 587 10 corticosteroids corticosteroid NNS cord-021413-1ht1xm88 587 11 on on IN cord-021413-1ht1xm88 587 12 mouse mouse NN cord-021413-1ht1xm88 587 13 hepatitis hepatitis NNP cord-021413-1ht1xm88 587 14 virus virus NN cord-021413-1ht1xm88 587 15 infection infection NN cord-021413-1ht1xm88 588 1 An an DT cord-021413-1ht1xm88 588 2 electron electron NN cord-021413-1ht1xm88 588 3 microscope microscope NN cord-021413-1ht1xm88 588 4 study study NN cord-021413-1ht1xm88 588 5 of of IN cord-021413-1ht1xm88 588 6 the the DT cord-021413-1ht1xm88 588 7 development development NN cord-021413-1ht1xm88 588 8 of of IN cord-021413-1ht1xm88 588 9 a a DT cord-021413-1ht1xm88 588 10 mouse mouse NN cord-021413-1ht1xm88 588 11 hepatitis hepatitis NN cord-021413-1ht1xm88 588 12 virus virus NN cord-021413-1ht1xm88 588 13 in in IN cord-021413-1ht1xm88 588 14 tissue tissue NN cord-021413-1ht1xm88 588 15 culture culture NN cord-021413-1ht1xm88 588 16 cells cell NNS cord-021413-1ht1xm88 588 17 Importance importance NN cord-021413-1ht1xm88 588 18 of of IN cord-021413-1ht1xm88 588 19 a a DT cord-021413-1ht1xm88 588 20 new new JJ cord-021413-1ht1xm88 588 21 virus virus NN cord-021413-1ht1xm88 588 22 in in IN cord-021413-1ht1xm88 588 23 acute acute JJ cord-021413-1ht1xm88 588 24 sporadic sporadic JJ cord-021413-1ht1xm88 588 25 enteritis enteritis NN cord-021413-1ht1xm88 588 26 in in IN cord-021413-1ht1xm88 588 27 children child NNS cord-021413-1ht1xm88 588 28 Comparison Comparison NNP cord-021413-1ht1xm88 588 29 of of IN cord-021413-1ht1xm88 588 30 the the DT cord-021413-1ht1xm88 588 31 morphology morphology NN cord-021413-1ht1xm88 588 32 of of IN cord-021413-1ht1xm88 588 33 three three CD cord-021413-1ht1xm88 588 34 coronaviruses coronaviruses NNPS cord-021413-1ht1xm88 588 35 Classification Classification NNP cord-021413-1ht1xm88 588 36 of of IN cord-021413-1ht1xm88 588 37 rotaviruses rotaviruses NNP cord-021413-1ht1xm88 588 38 : : : cord-021413-1ht1xm88 589 1 Report report VB cord-021413-1ht1xm88 589 2 from from IN cord-021413-1ht1xm88 589 3 the the DT cord-021413-1ht1xm88 589 4 Worid Worid NNP cord-021413-1ht1xm88 589 5 Health Health NNP cord-021413-1ht1xm88 589 6 Organization Organization NNP cord-021413-1ht1xm88 589 7 / / SYM cord-021413-1ht1xm88 589 8 Food Food NNP cord-021413-1ht1xm88 589 9 and and CC cord-021413-1ht1xm88 589 10 Agriculture Agriculture NNP cord-021413-1ht1xm88 589 11 Or or CC cord-021413-1ht1xm88 589 12 ganization ganization NN cord-021413-1ht1xm88 589 13 Comparative Comparative NNP cord-021413-1ht1xm88 589 14 Virology Virology NNP cord-021413-1ht1xm88 589 15 Program Program NNP cord-021413-1ht1xm88 589 16 Serologic Serologic NNP cord-021413-1ht1xm88 589 17 study study NN cord-021413-1ht1xm88 589 18 on on IN cord-021413-1ht1xm88 589 19 the the DT cord-021413-1ht1xm88 589 20 prevalence prevalence NN cord-021413-1ht1xm88 589 21 of of IN cord-021413-1ht1xm88 589 22 murine murine JJ cord-021413-1ht1xm88 589 23 viruses virus NNS cord-021413-1ht1xm88 589 24 in in IN cord-021413-1ht1xm88 589 25 five five CD cord-021413-1ht1xm88 589 26 Canadian canadian JJ cord-021413-1ht1xm88 589 27 mouse mouse NN cord-021413-1ht1xm88 589 28 colonies colony NNS cord-021413-1ht1xm88 590 1 A a DT cord-021413-1ht1xm88 590 2 virus virus NN cord-021413-1ht1xm88 590 3 related relate VBN cord-021413-1ht1xm88 590 4 to to IN cord-021413-1ht1xm88 590 5 that that DT cord-021413-1ht1xm88 590 6 causing cause VBG cord-021413-1ht1xm88 590 7 hepatitis hepatitis NN cord-021413-1ht1xm88 590 8 in in IN cord-021413-1ht1xm88 590 9 mice mouse NNS cord-021413-1ht1xm88 590 10 ( ( -LRB- cord-021413-1ht1xm88 590 11 MHV MHV NNP cord-021413-1ht1xm88 590 12 ) ) -RRB- cord-021413-1ht1xm88 590 13 Immunopathology immunopathology NN cord-021413-1ht1xm88 590 14 of of IN cord-021413-1ht1xm88 590 15 mouse mouse NN cord-021413-1ht1xm88 590 16 hepatitis hepatitis NNP cord-021413-1ht1xm88 590 17 virus virus NN cord-021413-1ht1xm88 590 18 type type NN cord-021413-1ht1xm88 590 19 3 3 CD cord-021413-1ht1xm88 590 20 . . . cord-021413-1ht1xm88 591 1 II II NNP cord-021413-1ht1xm88 591 2 . . . cord-021413-1ht1xm88 592 1 Effect effect NN cord-021413-1ht1xm88 592 2 of of IN cord-021413-1ht1xm88 592 3 i -PRON- PRP cord-021413-1ht1xm88 592 4 m be VBP cord-021413-1ht1xm88 592 5 munosuppression munosuppression NN cord-021413-1ht1xm88 592 6 in in IN cord-021413-1ht1xm88 592 7 resistant resistant JJ cord-021413-1ht1xm88 592 8 mice mouse NNS cord-021413-1ht1xm88 593 1 The the DT cord-021413-1ht1xm88 593 2 appearance appearance NN cord-021413-1ht1xm88 593 3 of of IN cord-021413-1ht1xm88 593 4 a a DT cord-021413-1ht1xm88 593 5 hepatotrophic hepatotrophic JJ cord-021413-1ht1xm88 593 6 virus virus NN cord-021413-1ht1xm88 593 7 in in IN cord-021413-1ht1xm88 593 8 mice mouse NNS cord-021413-1ht1xm88 593 9 thymectomized thymectomize VBN cord-021413-1ht1xm88 593 10 at at IN cord-021413-1ht1xm88 593 11 birth birth NN cord-021413-1ht1xm88 593 12 Comparison Comparison NNP cord-021413-1ht1xm88 593 13 of of IN cord-021413-1ht1xm88 593 14 five five CD cord-021413-1ht1xm88 593 15 diagnostic diagnostic JJ cord-021413-1ht1xm88 593 16 methods method NNS cord-021413-1ht1xm88 593 17 for for IN cord-021413-1ht1xm88 593 18 the the DT cord-021413-1ht1xm88 593 19 detection detection NN cord-021413-1ht1xm88 593 20 of of IN cord-021413-1ht1xm88 593 21 rotavirus rotavirus JJ cord-021413-1ht1xm88 593 22 antigens antigen NNS cord-021413-1ht1xm88 593 23 in in IN cord-021413-1ht1xm88 593 24 calf calf NN cord-021413-1ht1xm88 593 25 faeces faece NNS cord-021413-1ht1xm88 594 1 Morphological morphological JJ cord-021413-1ht1xm88 594 2 studies study NNS cord-021413-1ht1xm88 594 3 on on IN cord-021413-1ht1xm88 594 4 simian simian JJ cord-021413-1ht1xm88 594 5 virus virus NN cord-021413-1ht1xm88 594 6 SA SA NNP cord-021413-1ht1xm88 594 7 11 11 CD cord-021413-1ht1xm88 594 8 and and CC cord-021413-1ht1xm88 594 9 the the DT cord-021413-1ht1xm88 594 10 " " `` cord-021413-1ht1xm88 594 11 related related JJ cord-021413-1ht1xm88 594 12 " " '' cord-021413-1ht1xm88 594 13 0 0 CD cord-021413-1ht1xm88 594 14 agent agent NN cord-021413-1ht1xm88 594 15 Electron Electron NNP cord-021413-1ht1xm88 594 16 microscopic microscopic JJ cord-021413-1ht1xm88 594 17 identification identification NN cord-021413-1ht1xm88 594 18 and and CC cord-021413-1ht1xm88 594 19 subsequent subsequent JJ cord-021413-1ht1xm88 594 20 isolation isolation NN cord-021413-1ht1xm88 594 21 of of IN cord-021413-1ht1xm88 594 22 a a DT cord-021413-1ht1xm88 594 23 rotavirus rotavirus NN cord-021413-1ht1xm88 594 24 from from IN cord-021413-1ht1xm88 594 25 a a DT cord-021413-1ht1xm88 594 26 dog dog NN cord-021413-1ht1xm88 594 27 with with IN cord-021413-1ht1xm88 594 28 fatal fatal JJ cord-021413-1ht1xm88 594 29 neonatal neonatal JJ cord-021413-1ht1xm88 594 30 diarrhea diarrhea NN cord-021413-1ht1xm88 594 31 Enhancement enhancement NN cord-021413-1ht1xm88 594 32 of of IN cord-021413-1ht1xm88 594 33 rotavirus rotavirus JJ cord-021413-1ht1xm88 594 34 infectivity infectivity NN cord-021413-1ht1xm88 594 35 by by IN cord-021413-1ht1xm88 594 36 trypsin trypsin NN cord-021413-1ht1xm88 594 37 and and CC cord-021413-1ht1xm88 594 38 elastase elastase NN cord-021413-1ht1xm88 594 39 Identification identification NN cord-021413-1ht1xm88 594 40 of of IN cord-021413-1ht1xm88 594 41 rotaviruses rotavirus NNS cord-021413-1ht1xm88 594 42 of of IN cord-021413-1ht1xm88 594 43 different different JJ cord-021413-1ht1xm88 594 44 origins origin NNS cord-021413-1ht1xm88 594 45 by by IN cord-021413-1ht1xm88 594 46 the the DT cord-021413-1ht1xm88 594 47 plaque plaque NN cord-021413-1ht1xm88 594 48 - - HYPH cord-021413-1ht1xm88 594 49 reduction reduction NN cord-021413-1ht1xm88 594 50 test test NN cord-021413-1ht1xm88 594 51 Hemagglutination hemagglutination NN cord-021413-1ht1xm88 594 52 and and CC cord-021413-1ht1xm88 594 53 hemagglutination hemagglutination NN cord-021413-1ht1xm88 594 54 - - HYPH cord-021413-1ht1xm88 594 55 inhibition inhibition NN cord-021413-1ht1xm88 594 56 studies study NNS cord-021413-1ht1xm88 594 57 with with IN cord-021413-1ht1xm88 594 58 a a DT cord-021413-1ht1xm88 594 59 strain strain NN cord-021413-1ht1xm88 594 60 of of IN cord-021413-1ht1xm88 594 61 Nebraska Nebraska NNP cord-021413-1ht1xm88 594 62 calf calf NN cord-021413-1ht1xm88 594 63 diarrhea diarrhea NN cord-021413-1ht1xm88 594 64 virus virus NN cord-021413-1ht1xm88 594 65 ( ( -LRB- cord-021413-1ht1xm88 594 66 bovine bovine JJ cord-021413-1ht1xm88 594 67 rotavirus rotavirus NN cord-021413-1ht1xm88 594 68 ) ) -RRB- cord-021413-1ht1xm88 594 69 Isolation isolation NN cord-021413-1ht1xm88 594 70 and and CC cord-021413-1ht1xm88 594 71 preliminary preliminary JJ cord-021413-1ht1xm88 594 72 genetic genetic JJ cord-021413-1ht1xm88 594 73 and and CC cord-021413-1ht1xm88 594 74 biochemical biochemical JJ cord-021413-1ht1xm88 594 75 characterization characterization NN cord-021413-1ht1xm88 594 76 of of IN cord-021413-1ht1xm88 594 77 temperature temperature NN cord-021413-1ht1xm88 594 78 - - HYPH cord-021413-1ht1xm88 594 79 sensitive sensitive JJ cord-021413-1ht1xm88 594 80 mutants mutant NNS cord-021413-1ht1xm88 594 81 of of IN cord-021413-1ht1xm88 594 82 reovirus reovirus NNP cord-021413-1ht1xm88 594 83 Altered alter VBN cord-021413-1ht1xm88 594 84 disease disease NN cord-021413-1ht1xm88 594 85 in in IN cord-021413-1ht1xm88 594 86 rats rat NNS cord-021413-1ht1xm88 594 87 due due JJ cord-021413-1ht1xm88 594 88 to to IN cord-021413-1ht1xm88 594 89 mutants mutant NNS cord-021413-1ht1xm88 594 90 of of IN cord-021413-1ht1xm88 594 91 reovirus reovirus NNP cord-021413-1ht1xm88 594 92 type type NNP cord-021413-1ht1xm88 594 93 3 3 CD cord-021413-1ht1xm88 594 94 Temperature temperature NN cord-021413-1ht1xm88 594 95 - - HYPH cord-021413-1ht1xm88 594 96 sensitive sensitive JJ cord-021413-1ht1xm88 594 97 mutants mutant NNS cord-021413-1ht1xm88 594 98 of of IN cord-021413-1ht1xm88 594 99 reovirus reovirus NNP cord-021413-1ht1xm88 594 100 type type NNP cord-021413-1ht1xm88 594 101 3 3 CD cord-021413-1ht1xm88 594 102 : : : cord-021413-1ht1xm88 595 1 Studies study NNS cord-021413-1ht1xm88 595 2 on on IN cord-021413-1ht1xm88 595 3 the the DT cord-021413-1ht1xm88 595 4 synthesis synthesis NN cord-021413-1ht1xm88 595 5 of of IN cord-021413-1ht1xm88 595 6 viral viral JJ cord-021413-1ht1xm88 595 7 peptides peptide NNS cord-021413-1ht1xm88 595 8 Generation Generation NNP cord-021413-1ht1xm88 595 9 of of IN cord-021413-1ht1xm88 595 10 cytolytic cytolytic JJ cord-021413-1ht1xm88 595 11 Τ τ NN cord-021413-1ht1xm88 595 12 lymphocytes lymphocyte NNS cord-021413-1ht1xm88 595 13 after after IN cord-021413-1ht1xm88 595 14 reovirus reovirus NNP cord-021413-1ht1xm88 595 15 infection infection NN cord-021413-1ht1xm88 595 16 : : : cord-021413-1ht1xm88 595 17 role role NN cord-021413-1ht1xm88 595 18 of of IN cord-021413-1ht1xm88 595 19 the the DT cord-021413-1ht1xm88 595 20 SI SI NNP cord-021413-1ht1xm88 595 21 gene gene NN cord-021413-1ht1xm88 595 22 Nude Nude NNP cord-021413-1ht1xm88 595 23 " " '' cord-021413-1ht1xm88 595 24 , , , cord-021413-1ht1xm88 595 25 a a DT cord-021413-1ht1xm88 595 26 new new JJ cord-021413-1ht1xm88 595 27 hairless hairless JJ cord-021413-1ht1xm88 595 28 gene gene NN cord-021413-1ht1xm88 595 29 with with IN cord-021413-1ht1xm88 595 30 pleiotropic pleiotropic JJ cord-021413-1ht1xm88 595 31 effects effect NNS cord-021413-1ht1xm88 595 32 in in IN cord-021413-1ht1xm88 595 33 the the DT cord-021413-1ht1xm88 595 34 mouse mouse NN cord-021413-1ht1xm88 595 35 Electron Electron NNP cord-021413-1ht1xm88 595 36 microscopy microscopy NN cord-021413-1ht1xm88 595 37 in in IN cord-021413-1ht1xm88 595 38 the the DT cord-021413-1ht1xm88 595 39 diagnosis diagnosis NN cord-021413-1ht1xm88 595 40 of of IN cord-021413-1ht1xm88 595 41 infectious infectious JJ cord-021413-1ht1xm88 595 42 diarrhea diarrhea NN cord-021413-1ht1xm88 596 1 The the DT cord-021413-1ht1xm88 596 2 rotaviruses rotavirus NNS cord-021413-1ht1xm88 596 3 Relation relation NN cord-021413-1ht1xm88 596 4 between between IN cord-021413-1ht1xm88 596 5 viruses virus NNS cord-021413-1ht1xm88 596 6 from from IN cord-021413-1ht1xm88 596 7 acute acute JJ cord-021413-1ht1xm88 596 8 gastroen gastroen JJ cord-021413-1ht1xm88 596 9 teritis teritis NN cord-021413-1ht1xm88 596 10 of of IN cord-021413-1ht1xm88 596 11 children child NNS cord-021413-1ht1xm88 596 12 and and CC cord-021413-1ht1xm88 596 13 newborn newborn JJ cord-021413-1ht1xm88 596 14 calves calf NNS cord-021413-1ht1xm88 596 15 Virus virus NN cord-021413-1ht1xm88 596 16 diarrhoea diarrhoea NN cord-021413-1ht1xm88 596 17 in in IN cord-021413-1ht1xm88 596 18 foals foal NNS cord-021413-1ht1xm88 596 19 and and CC cord-021413-1ht1xm88 596 20 other other JJ cord-021413-1ht1xm88 596 21 animals animal NNS cord-021413-1ht1xm88 596 22 . . . cord-021413-1ht1xm88 597 1 Vet Vet NNP cord-021413-1ht1xm88 597 2 . . . cord-021413-1ht1xm88 598 1 Ree Ree NNP cord-021413-1ht1xm88 598 2 . . . cord-021413-1ht1xm88 599 1 96 96 CD cord-021413-1ht1xm88 600 1 Fluorescent fluorescent JJ cord-021413-1ht1xm88 600 2 virus virus NN cord-021413-1ht1xm88 600 3 precipitin precipitin NNS cord-021413-1ht1xm88 600 4 test test VBP cord-021413-1ht1xm88 600 5 Adverse adverse JJ cord-021413-1ht1xm88 600 6 effects effect NNS cord-021413-1ht1xm88 600 7 of of IN cord-021413-1ht1xm88 600 8 mouse mouse NN cord-021413-1ht1xm88 600 9 hepatitis hepatitis NN cord-021413-1ht1xm88 600 10 virus virus NN cord-021413-1ht1xm88 600 11 on on IN cord-021413-1ht1xm88 600 12 ascites ascites NN cord-021413-1ht1xm88 600 13 myeloma myeloma NN cord-021413-1ht1xm88 600 14 passage passage NN cord-021413-1ht1xm88 600 15 in in IN cord-021413-1ht1xm88 600 16 the the DT cord-021413-1ht1xm88 600 17 Balb Balb NNP cord-021413-1ht1xm88 600 18 / / SYM cord-021413-1ht1xm88 600 19 cJ cj CD cord-021413-1ht1xm88 600 20 mouse mouse NN cord-021413-1ht1xm88 600 21 Problems problem NNS cord-021413-1ht1xm88 600 22 in in IN cord-021413-1ht1xm88 600 23 checking check VBG cord-021413-1ht1xm88 600 24 inapparent inapparent JJ cord-021413-1ht1xm88 600 25 infections infection NNS cord-021413-1ht1xm88 600 26 in in IN cord-021413-1ht1xm88 600 27 laboratory laboratory NN cord-021413-1ht1xm88 600 28 mouse mouse NN cord-021413-1ht1xm88 600 29 colonies colony NNS cord-021413-1ht1xm88 600 30 : : : cord-021413-1ht1xm88 601 1 An an DT cord-021413-1ht1xm88 601 2 attempt attempt NN cord-021413-1ht1xm88 601 3 at at IN cord-021413-1ht1xm88 601 4 serological serological JJ cord-021413-1ht1xm88 601 5 checking checking NN cord-021413-1ht1xm88 601 6 by by IN cord-021413-1ht1xm88 601 7 anamnestic anamnestic NNP cord-021413-1ht1xm88 601 8 re re IN cord-021413-1ht1xm88 601 9 sponse sponse NNP cord-021413-1ht1xm88 601 10 Implication Implication NNP cord-021413-1ht1xm88 601 11 pancréatique pancréatique NN cord-021413-1ht1xm88 601 12 chez chez FW cord-021413-1ht1xm88 601 13 la la FW cord-021413-1ht1xm88 601 14 souris souris NNP cord-021413-1ht1xm88 601 15 infectée infectée NNP cord-021413-1ht1xm88 601 16 avec avec FW cord-021413-1ht1xm88 601 17 le le FW cord-021413-1ht1xm88 601 18 virus virus NN cord-021413-1ht1xm88 601 19 de de FW cord-021413-1ht1xm88 601 20 l'hépatite l'hépatite FW cord-021413-1ht1xm88 601 21 murine murine JJ cord-021413-1ht1xm88 601 22 Immunisation Immunisation NNP cord-021413-1ht1xm88 601 23 de de NNP cord-021413-1ht1xm88 601 24 la la NNP cord-021413-1ht1xm88 601 25 souris souris NNP cord-021413-1ht1xm88 601 26 " " `` cord-021413-1ht1xm88 601 27 nude nude NNP cord-021413-1ht1xm88 601 28 " " '' cord-021413-1ht1xm88 601 29 contre contre FW cord-021413-1ht1xm88 601 30 le le FW cord-021413-1ht1xm88 601 31 virus virus NN cord-021413-1ht1xm88 601 32 de de FW cord-021413-1ht1xm88 601 33 l'hépatite l'hépatite NNP cord-021413-1ht1xm88 601 34 murine murine NNP cord-021413-1ht1xm88 601 35 par par NNP cord-021413-1ht1xm88 601 36 transfert transfert NNP cord-021413-1ht1xm88 601 37 de de FW cord-021413-1ht1xm88 601 38 lymphocytes lymphocytes NNP cord-021413-1ht1xm88 601 39 sensibilisés sensibilisés NNP cord-021413-1ht1xm88 601 40 Carrier Carrier NNP cord-021413-1ht1xm88 601 41 state state NN cord-021413-1ht1xm88 601 42 of of IN cord-021413-1ht1xm88 601 43 anti anti JJ cord-021413-1ht1xm88 601 44 body body NN cord-021413-1ht1xm88 601 45 and and CC cord-021413-1ht1xm88 601 46 viruses virus NNS cord-021413-1ht1xm88 601 47 in in IN cord-021413-1ht1xm88 601 48 a a DT cord-021413-1ht1xm88 601 49 mouse mouse NN cord-021413-1ht1xm88 601 50 breeding breed VBG cord-021413-1ht1xm88 601 51 colony colony NN cord-021413-1ht1xm88 601 52 persistently persistently RB cord-021413-1ht1xm88 601 53 infected infect VBN cord-021413-1ht1xm88 601 54 with with IN cord-021413-1ht1xm88 601 55 Sendai Sendai NNP cord-021413-1ht1xm88 601 56 and and CC cord-021413-1ht1xm88 601 57 mouse mouse NN cord-021413-1ht1xm88 601 58 hepatitis hepatitis NN cord-021413-1ht1xm88 601 59 viruses virus NNS cord-021413-1ht1xm88 602 1 Effect effect NN cord-021413-1ht1xm88 602 2 of of IN cord-021413-1ht1xm88 602 3 cortisone cortisone NN cord-021413-1ht1xm88 602 4 on on IN cord-021413-1ht1xm88 602 5 genetic genetic JJ cord-021413-1ht1xm88 602 6 resistance resistance NN cord-021413-1ht1xm88 602 7 to to TO cord-021413-1ht1xm88 602 8 mouse mouse VB cord-021413-1ht1xm88 602 9 hepatitis hepatitis NNP cord-021413-1ht1xm88 602 10 virus virus NN cord-021413-1ht1xm88 602 11 in in IN cord-021413-1ht1xm88 602 12 vivo vivo NNP cord-021413-1ht1xm88 602 13 and and CC cord-021413-1ht1xm88 602 14 in in IN cord-021413-1ht1xm88 602 15 vitro vitro FW cord-021413-1ht1xm88 602 16 Ontogeny ontogeny NN cord-021413-1ht1xm88 602 17 of of IN cord-021413-1ht1xm88 602 18 macrophage macrophage NN cord-021413-1ht1xm88 602 19 resistance resistance NN cord-021413-1ht1xm88 602 20 to to IN cord-021413-1ht1xm88 602 21 mouse mouse VB cord-021413-1ht1xm88 602 22 hepatitis hepatitis NN cord-021413-1ht1xm88 602 23 in in IN cord-021413-1ht1xm88 602 24 vivo vivo NNP cord-021413-1ht1xm88 602 25 and and CC cord-021413-1ht1xm88 602 26 in in IN cord-021413-1ht1xm88 602 27 vitro vitro FW cord-021413-1ht1xm88 602 28 Structure structure NN cord-021413-1ht1xm88 602 29 and and CC cord-021413-1ht1xm88 602 30 physicochemical physicochemical JJ cord-021413-1ht1xm88 602 31 properties property NNS cord-021413-1ht1xm88 602 32 of of IN cord-021413-1ht1xm88 602 33 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 602 34 Comparison comparison NN cord-021413-1ht1xm88 602 35 of of IN cord-021413-1ht1xm88 602 36 an an DT cord-021413-1ht1xm88 602 37 enzyme enzyme NN cord-021413-1ht1xm88 602 38 - - HYPH cord-021413-1ht1xm88 602 39 linked link VBN cord-021413-1ht1xm88 602 40 immunosorbent immunosorbent JJ cord-021413-1ht1xm88 602 41 assay assay NN cord-021413-1ht1xm88 602 42 for for IN cord-021413-1ht1xm88 602 43 quantitation quantitation NN cord-021413-1ht1xm88 602 44 of of IN cord-021413-1ht1xm88 602 45 rotavirus rotavirus NN cord-021413-1ht1xm88 602 46 an an DT cord-021413-1ht1xm88 602 47 tibodies tibodie NNS cord-021413-1ht1xm88 602 48 with with IN cord-021413-1ht1xm88 602 49 complement complement JJ cord-021413-1ht1xm88 602 50 fixation fixation NN cord-021413-1ht1xm88 602 51 in in IN cord-021413-1ht1xm88 602 52 an an DT cord-021413-1ht1xm88 602 53 epidemiological epidemiological JJ cord-021413-1ht1xm88 602 54 survey survey NN cord-021413-1ht1xm88 602 55 Enhancement enhancement NN cord-021413-1ht1xm88 602 56 of of IN cord-021413-1ht1xm88 602 57 the the DT cord-021413-1ht1xm88 602 58 pathogenicity pathogenicity NN cord-021413-1ht1xm88 602 59 of of IN cord-021413-1ht1xm88 602 60 mouse mouse NN cord-021413-1ht1xm88 602 61 hepatitis hepatitis NNP cord-021413-1ht1xm88 602 62 virus virus NN cord-021413-1ht1xm88 602 63 ( ( -LRB- cord-021413-1ht1xm88 602 64 MHVl MHVl NNS cord-021413-1ht1xm88 602 65 ) ) -RRB- cord-021413-1ht1xm88 602 66 by by IN cord-021413-1ht1xm88 602 67 prior prior JJ cord-021413-1ht1xm88 602 68 infection infection NN cord-021413-1ht1xm88 602 69 of of IN cord-021413-1ht1xm88 602 70 mice mouse NNS cord-021413-1ht1xm88 602 71 with with IN cord-021413-1ht1xm88 602 72 certain certain JJ cord-021413-1ht1xm88 602 73 leukaemia leukaemia NN cord-021413-1ht1xm88 602 74 agents agent NNS cord-021413-1ht1xm88 602 75 A a DT cord-021413-1ht1xm88 602 76 hepatitis hepatitis NN cord-021413-1ht1xm88 602 77 virus virus NN cord-021413-1ht1xm88 602 78 of of IN cord-021413-1ht1xm88 602 79 mice mouse NNS cord-021413-1ht1xm88 602 80 Production Production NNP cord-021413-1ht1xm88 602 81 of of IN cord-021413-1ht1xm88 602 82 hepatitis hepatitis NN cord-021413-1ht1xm88 602 83 in in IN cord-021413-1ht1xm88 602 84 mice mouse NNS cord-021413-1ht1xm88 602 85 by by IN cord-021413-1ht1xm88 602 86 the the DT cord-021413-1ht1xm88 602 87 combined combine VBN cord-021413-1ht1xm88 602 88 action action NN cord-021413-1ht1xm88 602 89 of of IN cord-021413-1ht1xm88 602 90 two two CD cord-021413-1ht1xm88 602 91 filterable filterable JJ cord-021413-1ht1xm88 602 92 agents agent NNS cord-021413-1ht1xm88 602 93 Mouse Mouse NNP cord-021413-1ht1xm88 602 94 hepatitis hepatitis NN cord-021413-1ht1xm88 602 95 virus virus NN cord-021413-1ht1xm88 602 96 and and CC cord-021413-1ht1xm88 602 97 its -PRON- PRP$ cord-021413-1ht1xm88 602 98 pathogenic pathogenic JJ cord-021413-1ht1xm88 602 99 action action NN cord-021413-1ht1xm88 602 100 Reactive Reactive NNP cord-021413-1ht1xm88 602 101 sites site NNS cord-021413-1ht1xm88 602 102 of of IN cord-021413-1ht1xm88 602 103 reovirus reovirus NNP cord-021413-1ht1xm88 602 104 type type NNP cord-021413-1ht1xm88 602 105 3 3 CD cord-021413-1ht1xm88 602 106 and and CC cord-021413-1ht1xm88 602 107 their -PRON- PRP$ cord-021413-1ht1xm88 602 108 interaction interaction NN cord-021413-1ht1xm88 602 109 with with IN cord-021413-1ht1xm88 602 110 receptor receptor NN cord-021413-1ht1xm88 602 111 substances substance NNS cord-021413-1ht1xm88 602 112 Reovirus Reovirus NNP cord-021413-1ht1xm88 602 113 type type NN cord-021413-1ht1xm88 602 114 3 3 CD cord-021413-1ht1xm88 602 115 : : : cord-021413-1ht1xm88 602 116 Physical physical JJ cord-021413-1ht1xm88 602 117 characteristics characteristic NNS cord-021413-1ht1xm88 602 118 and and CC cord-021413-1ht1xm88 602 119 interaction interaction NN cord-021413-1ht1xm88 602 120 with with IN cord-021413-1ht1xm88 602 121 L l NN cord-021413-1ht1xm88 602 122 cells cell NNS cord-021413-1ht1xm88 603 1 The the DT cord-021413-1ht1xm88 603 2 propagation propagation NN cord-021413-1ht1xm88 603 3 of of IN cord-021413-1ht1xm88 603 4 S S NNP cord-021413-1ht1xm88 603 5 virus virus NN cord-021413-1ht1xm88 603 6 of of IN cord-021413-1ht1xm88 603 7 mouse mouse NN cord-021413-1ht1xm88 603 8 hepatitis hepatitis NN cord-021413-1ht1xm88 603 9 in in IN cord-021413-1ht1xm88 603 10 tissue tissue NN cord-021413-1ht1xm88 603 11 culture culture NN cord-021413-1ht1xm88 604 1 Comparison comparison NN cord-021413-1ht1xm88 604 2 of of IN cord-021413-1ht1xm88 604 3 methods method NNS cord-021413-1ht1xm88 604 4 for for IN cord-021413-1ht1xm88 604 5 immunocytochemical immunocytochemical JJ cord-021413-1ht1xm88 604 6 detection detection NN cord-021413-1ht1xm88 604 7 of of IN cord-021413-1ht1xm88 604 8 rotavirus rotavirus JJ cord-021413-1ht1xm88 604 9 infections infection NNS cord-021413-1ht1xm88 605 1 Delayed delay VBN cord-021413-1ht1xm88 605 2 hypersensitivity hypersensitivity NN cord-021413-1ht1xm88 605 3 in in IN cord-021413-1ht1xm88 605 4 mice mouse NNS cord-021413-1ht1xm88 605 5 infected infect VBN cord-021413-1ht1xm88 605 6 with with IN cord-021413-1ht1xm88 605 7 reovirus reovirus NNP cord-021413-1ht1xm88 605 8 . . . cord-021413-1ht1xm88 606 1 II II NNP cord-021413-1ht1xm88 606 2 . . . cord-021413-1ht1xm88 607 1 Induction induction NN cord-021413-1ht1xm88 607 2 of of IN cord-021413-1ht1xm88 607 3 tolerance tolerance NN cord-021413-1ht1xm88 607 4 and and CC cord-021413-1ht1xm88 607 5 suppressor suppressor NN cord-021413-1ht1xm88 607 6 Τ τ NN cord-021413-1ht1xm88 607 7 cells cell NNS cord-021413-1ht1xm88 607 8 to to IN cord-021413-1ht1xm88 607 9 viral viral JJ cord-021413-1ht1xm88 607 10 specific specific JJ cord-021413-1ht1xm88 607 11 gene gene NN cord-021413-1ht1xm88 607 12 products product NNS cord-021413-1ht1xm88 607 13 Spontaneous spontaneous JJ cord-021413-1ht1xm88 607 14 diseases disease NNS cord-021413-1ht1xm88 607 15 and and CC cord-021413-1ht1xm88 607 16 their -PRON- PRP$ cord-021413-1ht1xm88 607 17 control control NN cord-021413-1ht1xm88 607 18 in in IN cord-021413-1ht1xm88 607 19 laboratory laboratory NN cord-021413-1ht1xm88 607 20 animals animal NNS cord-021413-1ht1xm88 607 21 Electron Electron NNP cord-021413-1ht1xm88 607 22 microscopic microscopic JJ cord-021413-1ht1xm88 607 23 examination examination NN cord-021413-1ht1xm88 607 24 of of IN cord-021413-1ht1xm88 607 25 cells cell NNS cord-021413-1ht1xm88 607 26 infected infect VBN cord-021413-1ht1xm88 607 27 with with IN cord-021413-1ht1xm88 607 28 reovirus reovirus NNP cord-021413-1ht1xm88 607 29 Tissue tissue NN cord-021413-1ht1xm88 607 30 culture culture NN cord-021413-1ht1xm88 607 31 cytopathic cytopathic JJ cord-021413-1ht1xm88 607 32 and and CC cord-021413-1ht1xm88 607 33 plaque plaque NN cord-021413-1ht1xm88 607 34 assays assay NNS cord-021413-1ht1xm88 607 35 for for IN cord-021413-1ht1xm88 607 36 mouse mouse NN cord-021413-1ht1xm88 607 37 hepatitis hepatitis NN cord-021413-1ht1xm88 607 38 viruses virus NNS cord-021413-1ht1xm88 607 39 Recovery Recovery NNP cord-021413-1ht1xm88 607 40 of of IN cord-021413-1ht1xm88 607 41 reoviruses reovirus NNS cord-021413-1ht1xm88 607 42 from from IN cord-021413-1ht1xm88 607 43 wild wild JJ cord-021413-1ht1xm88 607 44 and and CC cord-021413-1ht1xm88 607 45 laboratory laboratory NN cord-021413-1ht1xm88 607 46 mice mouse NNS cord-021413-1ht1xm88 607 47 Antibodies antibody NNS cord-021413-1ht1xm88 607 48 to to TO cord-021413-1ht1xm88 607 49 mouse mouse VB cord-021413-1ht1xm88 607 50 hepatitis hepatitis NN cord-021413-1ht1xm88 607 51 viruses virus NNS cord-021413-1ht1xm88 607 52 in in IN cord-021413-1ht1xm88 607 53 human human JJ cord-021413-1ht1xm88 607 54 sera sera NNP cord-021413-1ht1xm88 607 55 Temperature temperature NN cord-021413-1ht1xm88 607 56 - - HYPH cord-021413-1ht1xm88 607 57 sensitive sensitive JJ cord-021413-1ht1xm88 607 58 mutants mutant NNS cord-021413-1ht1xm88 607 59 of of IN cord-021413-1ht1xm88 607 60 mouse mouse NN cord-021413-1ht1xm88 607 61 hepatitis hepatitis NNP cord-021413-1ht1xm88 607 62 virus virus NN cord-021413-1ht1xm88 607 63 produce produce VBP cord-021413-1ht1xm88 607 64 a a DT cord-021413-1ht1xm88 607 65 high high JJ cord-021413-1ht1xm88 607 66 incidence incidence NN cord-021413-1ht1xm88 607 67 of of IN cord-021413-1ht1xm88 607 68 demyelination demyelination NN cord-021413-1ht1xm88 607 69 Mouse Mouse NNP cord-021413-1ht1xm88 607 70 hepatitis hepatitis NN cord-021413-1ht1xm88 607 71 virus virus NN cord-021413-1ht1xm88 607 72 - - HYPH cord-021413-1ht1xm88 607 73 induced induce VBN cord-021413-1ht1xm88 607 74 recurrent recurrent JJ cord-021413-1ht1xm88 607 75 demyelination demyelination NN cord-021413-1ht1xm88 607 76 Quantitation Quantitation NNP cord-021413-1ht1xm88 607 77 of of IN cord-021413-1ht1xm88 607 78 antibody antibody NN cord-021413-1ht1xm88 607 79 to to IN cord-021413-1ht1xm88 607 80 non non JJ cord-021413-1ht1xm88 607 81 - - JJ cord-021413-1ht1xm88 607 82 hemagglutinating hemagglutinating JJ cord-021413-1ht1xm88 607 83 viruses virus NNS cord-021413-1ht1xm88 607 84 by by IN cord-021413-1ht1xm88 607 85 single single JJ cord-021413-1ht1xm88 607 86 radial radial JJ cord-021413-1ht1xm88 607 87 hemolysis hemolysis NN cord-021413-1ht1xm88 607 88 : : : cord-021413-1ht1xm88 608 1 Serological serological JJ cord-021413-1ht1xm88 608 2 test test NN cord-021413-1ht1xm88 608 3 for for IN cord-021413-1ht1xm88 608 4 human human JJ cord-021413-1ht1xm88 608 5 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 608 6 New new JJ cord-021413-1ht1xm88 608 7 strain strain NN cord-021413-1ht1xm88 608 8 of of IN cord-021413-1ht1xm88 608 9 mouse mouse NN cord-021413-1ht1xm88 608 10 hepatitis hepatitis NN cord-021413-1ht1xm88 608 11 virus virus NN cord-021413-1ht1xm88 608 12 as as IN cord-021413-1ht1xm88 608 13 the the DT cord-021413-1ht1xm88 608 14 cause cause NN cord-021413-1ht1xm88 608 15 of of IN cord-021413-1ht1xm88 608 16 lethal lethal JJ cord-021413-1ht1xm88 608 17 enteritis enteritis NN cord-021413-1ht1xm88 608 18 in in IN cord-021413-1ht1xm88 608 19 infant infant NN cord-021413-1ht1xm88 608 20 mice mouse NNS cord-021413-1ht1xm88 608 21 Isolation isolation NN cord-021413-1ht1xm88 608 22 of of IN cord-021413-1ht1xm88 608 23 low low JJ cord-021413-1ht1xm88 608 24 - - HYPH cord-021413-1ht1xm88 608 25 virulent virulent JJ cord-021413-1ht1xm88 608 26 mouse mouse NN cord-021413-1ht1xm88 608 27 hepatitis hepatitis NN cord-021413-1ht1xm88 608 28 virus virus NN cord-021413-1ht1xm88 608 29 from from IN cord-021413-1ht1xm88 608 30 nude nude JJ cord-021413-1ht1xm88 608 31 mice mouse NNS cord-021413-1ht1xm88 608 32 with with IN cord-021413-1ht1xm88 608 33 wasting waste VBG cord-021413-1ht1xm88 608 34 syndrome syndrome NN cord-021413-1ht1xm88 608 35 and and CC cord-021413-1ht1xm88 608 36 hepatitis hepatitis NNP cord-021413-1ht1xm88 608 37 Studies Studies NNPS cord-021413-1ht1xm88 608 38 on on IN cord-021413-1ht1xm88 608 39 the the DT cord-021413-1ht1xm88 608 40 mechanism mechanism NN cord-021413-1ht1xm88 608 41 of of IN cord-021413-1ht1xm88 608 42 destruc destruc JJ cord-021413-1ht1xm88 608 43 tion tion NN cord-021413-1ht1xm88 608 44 of of IN cord-021413-1ht1xm88 608 45 lymphoid lymphoid JJ cord-021413-1ht1xm88 608 46 tissue tissue NN cord-021413-1ht1xm88 608 47 in in IN cord-021413-1ht1xm88 608 48 murine murine JJ cord-021413-1ht1xm88 608 49 hepatitis hepatitis NN cord-021413-1ht1xm88 608 50 virus virus NN cord-021413-1ht1xm88 608 51 ( ( -LRB- cord-021413-1ht1xm88 608 52 MHV3 MHV3 NNP cord-021413-1ht1xm88 608 53 ) ) -RRB- cord-021413-1ht1xm88 608 54 infection infection NN cord-021413-1ht1xm88 608 55 . . . cord-021413-1ht1xm88 609 1 I. I. NNP cord-021413-1ht1xm88 609 2 Selective selective JJ cord-021413-1ht1xm88 609 3 prevention prevention NN cord-021413-1ht1xm88 609 4 of of IN cord-021413-1ht1xm88 609 5 lymphoid lymphoid JJ cord-021413-1ht1xm88 609 6 necrosis necrosis NN cord-021413-1ht1xm88 609 7 by by IN cord-021413-1ht1xm88 609 8 cortisone cortisone NN cord-021413-1ht1xm88 609 9 and and CC cord-021413-1ht1xm88 609 10 puromycin puromycin NNP cord-021413-1ht1xm88 609 11 Physico Physico NNP cord-021413-1ht1xm88 609 12 - - HYPH cord-021413-1ht1xm88 609 13 chemical chemical NN cord-021413-1ht1xm88 609 14 properties property NNS cord-021413-1ht1xm88 609 15 of of IN cord-021413-1ht1xm88 609 16 mouse mouse NNP cord-021413-1ht1xm88 609 17 hepatitis hepatitis NNP cord-021413-1ht1xm88 609 18 virus virus NN cord-021413-1ht1xm88 609 19 ( ( -LRB- cord-021413-1ht1xm88 609 20 MHV-2 mhv-2 NN cord-021413-1ht1xm88 609 21 ) ) -RRB- cord-021413-1ht1xm88 609 22 grown grow VBN cord-021413-1ht1xm88 609 23 on on IN cord-021413-1ht1xm88 609 24 DBT dbt NN cord-021413-1ht1xm88 609 25 cell cell NN cord-021413-1ht1xm88 609 26 culture culture NN cord-021413-1ht1xm88 609 27 Viral viral JJ cord-021413-1ht1xm88 609 28 gastroenteritis gastroenteritis NN cord-021413-1ht1xm88 610 1 Infantile infantile JJ cord-021413-1ht1xm88 610 2 enteritis enteritis NN cord-021413-1ht1xm88 610 3 viruses virus NNS cord-021413-1ht1xm88 610 4 : : : cord-021413-1ht1xm88 610 5 morphogenesis morphogenesis NN cord-021413-1ht1xm88 610 6 and and CC cord-021413-1ht1xm88 610 7 morphology morphology NN cord-021413-1ht1xm88 610 8 Is be VBZ cord-021413-1ht1xm88 610 9 lactase lactase NN cord-021413-1ht1xm88 610 10 the the DT cord-021413-1ht1xm88 610 11 receptor receptor NN cord-021413-1ht1xm88 610 12 and and CC cord-021413-1ht1xm88 610 13 uncoating uncoating NN cord-021413-1ht1xm88 610 14 enzyme enzyme NN cord-021413-1ht1xm88 610 15 for for IN cord-021413-1ht1xm88 610 16 infantile infantile JJ cord-021413-1ht1xm88 610 17 enteritis enteritis NN cord-021413-1ht1xm88 610 18 ( ( -LRB- cord-021413-1ht1xm88 610 19 rota rota NN cord-021413-1ht1xm88 610 20 ) ) -RRB- cord-021413-1ht1xm88 610 21 viruses virus NNS cord-021413-1ht1xm88 610 22 ? ? . cord-021413-1ht1xm88 611 1 Some some DT cord-021413-1ht1xm88 611 2 distinctive distinctive JJ cord-021413-1ht1xm88 611 3 biological biological JJ cord-021413-1ht1xm88 611 4 characteristics characteristic NNS cord-021413-1ht1xm88 611 5 of of IN cord-021413-1ht1xm88 611 6 ECHO-10 echo-10 JJ cord-021413-1ht1xm88 611 7 virus virus NN cord-021413-1ht1xm88 611 8 New new JJ cord-021413-1ht1xm88 611 9 viral viral JJ cord-021413-1ht1xm88 611 10 agents agent NNS cord-021413-1ht1xm88 611 11 recovered recover VBN cord-021413-1ht1xm88 611 12 from from IN cord-021413-1ht1xm88 611 13 tissue tissue NN cord-021413-1ht1xm88 611 14 cultures culture NNS cord-021413-1ht1xm88 611 15 of of IN cord-021413-1ht1xm88 611 16 monkey monkey NN cord-021413-1ht1xm88 611 17 kidney kidney NN cord-021413-1ht1xm88 611 18 cells cell NNS cord-021413-1ht1xm88 611 19 . . . cord-021413-1ht1xm88 612 1 I. I. NNP cord-021413-1ht1xm88 612 2 Origin Origin NNP cord-021413-1ht1xm88 612 3 and and CC cord-021413-1ht1xm88 612 4 properties property NNS cord-021413-1ht1xm88 612 5 of of IN cord-021413-1ht1xm88 612 6 cytopathogenic cytopathogenic JJ cord-021413-1ht1xm88 612 7 agents agent NNS cord-021413-1ht1xm88 612 8 SVj SVj NNPS cord-021413-1ht1xm88 612 9 , , , cord-021413-1ht1xm88 612 10 SV2 SV2 NNP cord-021413-1ht1xm88 612 11 , , , cord-021413-1ht1xm88 612 12 SV4 SV4 NNP cord-021413-1ht1xm88 612 13 , , , cord-021413-1ht1xm88 612 14 SV5 sv5 NN cord-021413-1ht1xm88 612 15 , , , cord-021413-1ht1xm88 612 16 SVg SVg NNS cord-021413-1ht1xm88 612 17 , , , cord-021413-1ht1xm88 612 18 SVn SVn NNS cord-021413-1ht1xm88 612 19 , , , cord-021413-1ht1xm88 612 20 SV12 SV12 NNP cord-021413-1ht1xm88 612 21 , , , cord-021413-1ht1xm88 612 22 and and CC cord-021413-1ht1xm88 612 23 SV15 SV15 NNP cord-021413-1ht1xm88 612 24 Pathology Pathology NNP cord-021413-1ht1xm88 612 25 of of IN cord-021413-1ht1xm88 612 26 diarrhea diarrhea NN cord-021413-1ht1xm88 612 27 due due IN cord-021413-1ht1xm88 612 28 to to IN cord-021413-1ht1xm88 612 29 mouse mouse NNP cord-021413-1ht1xm88 612 30 hepatitis hepatitis NNP cord-021413-1ht1xm88 612 31 virus virus NN cord-021413-1ht1xm88 612 32 in in IN cord-021413-1ht1xm88 612 33 the the DT cord-021413-1ht1xm88 612 34 infant infant NN cord-021413-1ht1xm88 612 35 mouse mouse NN cord-021413-1ht1xm88 612 36 Isolation Isolation NNP cord-021413-1ht1xm88 612 37 of of IN cord-021413-1ht1xm88 612 38 mouse mouse NN cord-021413-1ht1xm88 612 39 hepatitis hepatitis NN cord-021413-1ht1xm88 612 40 virus virus NN cord-021413-1ht1xm88 612 41 from from IN cord-021413-1ht1xm88 612 42 infant infant NN cord-021413-1ht1xm88 612 43 mice mouse NNS cord-021413-1ht1xm88 612 44 with with IN cord-021413-1ht1xm88 612 45 fatal fatal JJ cord-021413-1ht1xm88 612 46 diarrhea diarrhea NN cord-021413-1ht1xm88 613 1 Some some DT cord-021413-1ht1xm88 613 2 aspects aspect NNS cord-021413-1ht1xm88 613 3 on on IN cord-021413-1ht1xm88 613 4 the the DT cord-021413-1ht1xm88 613 5 transmission transmission NN cord-021413-1ht1xm88 613 6 of of IN cord-021413-1ht1xm88 613 7 hepatitis hepatitis NN cord-021413-1ht1xm88 613 8 Β β NN cord-021413-1ht1xm88 613 9 antigen antigen NN cord-021413-1ht1xm88 613 10 ; ; : cord-021413-1ht1xm88 613 11 model model NN cord-021413-1ht1xm88 613 12 experiments experiment NNS cord-021413-1ht1xm88 613 13 by by IN cord-021413-1ht1xm88 613 14 mosquitoes mosquito NNS cord-021413-1ht1xm88 613 15 with with IN cord-021413-1ht1xm88 613 16 murine murine JJ cord-021413-1ht1xm88 613 17 hepatitis hepatitis NN cord-021413-1ht1xm88 613 18 virus virus NN cord-021413-1ht1xm88 614 1 The the DT cord-021413-1ht1xm88 614 2 molecular molecular JJ cord-021413-1ht1xm88 614 3 biology biology NN cord-021413-1ht1xm88 614 4 of of IN cord-021413-1ht1xm88 614 5 reovirus reovirus NNP cord-021413-1ht1xm88 614 6 Studies Studies NNPS cord-021413-1ht1xm88 614 7 on on IN cord-021413-1ht1xm88 614 8 the the DT cord-021413-1ht1xm88 614 9 effect effect NN cord-021413-1ht1xm88 614 10 of of IN cord-021413-1ht1xm88 614 11 chymotrypsin chymotrypsin NNP cord-021413-1ht1xm88 614 12 on on IN cord-021413-1ht1xm88 614 13 reovirions reovirion NNS cord-021413-1ht1xm88 614 14 Reproduction Reproduction NNP cord-021413-1ht1xm88 614 15 of of IN cord-021413-1ht1xm88 614 16 reoviridae reoviridae NNP cord-021413-1ht1xm88 615 1 The the DT cord-021413-1ht1xm88 615 2 effect effect NN cord-021413-1ht1xm88 615 3 of of IN cord-021413-1ht1xm88 615 4 a a DT cord-021413-1ht1xm88 615 5 murine murine JJ cord-021413-1ht1xm88 615 6 hepatitis hepatitis NN cord-021413-1ht1xm88 615 7 virus virus NN cord-021413-1ht1xm88 615 8 on on IN cord-021413-1ht1xm88 615 9 the the DT cord-021413-1ht1xm88 615 10 liver liver NN cord-021413-1ht1xm88 616 1 The the DT cord-021413-1ht1xm88 616 2 fine fine JJ cord-021413-1ht1xm88 616 3 structure structure NN cord-021413-1ht1xm88 616 4 of of IN cord-021413-1ht1xm88 616 5 reovirus reovirus NNP cord-021413-1ht1xm88 616 6 , , , cord-021413-1ht1xm88 616 7 a a DT cord-021413-1ht1xm88 616 8 new new JJ cord-021413-1ht1xm88 616 9 member member NN cord-021413-1ht1xm88 616 10 of of IN cord-021413-1ht1xm88 616 11 the the DT cord-021413-1ht1xm88 616 12 icosahedral icosahedral JJ cord-021413-1ht1xm88 616 13 series series NN cord-021413-1ht1xm88 617 1 A a DT cord-021413-1ht1xm88 617 2 microtiter microtiter JJ cord-021413-1ht1xm88 617 3 solid solid JJ cord-021413-1ht1xm88 617 4 phase phase NN cord-021413-1ht1xm88 617 5 radioimmunoassay radioimmunoassay JJ cord-021413-1ht1xm88 617 6 for for IN cord-021413-1ht1xm88 617 7 detection detection NN cord-021413-1ht1xm88 617 8 of of IN cord-021413-1ht1xm88 617 9 the the DT cord-021413-1ht1xm88 617 10 human human JJ cord-021413-1ht1xm88 617 11 reovirus reovirus NNP cord-021413-1ht1xm88 617 12 - - HYPH cord-021413-1ht1xm88 617 13 like like JJ cord-021413-1ht1xm88 617 14 agent agent NN cord-021413-1ht1xm88 617 15 in in IN cord-021413-1ht1xm88 617 16 stools stool NNS cord-021413-1ht1xm88 617 17 Detection detection NN cord-021413-1ht1xm88 617 18 of of IN cord-021413-1ht1xm88 617 19 differences difference NNS cord-021413-1ht1xm88 617 20 among among IN cord-021413-1ht1xm88 617 21 human human JJ cord-021413-1ht1xm88 617 22 and and CC cord-021413-1ht1xm88 617 23 animal animal NN cord-021413-1ht1xm88 617 24 rotaviruses rotavirus NNS cord-021413-1ht1xm88 617 25 using use VBG cord-021413-1ht1xm88 617 26 analysis analysis NN cord-021413-1ht1xm88 617 27 of of IN cord-021413-1ht1xm88 617 28 viral viral JJ cord-021413-1ht1xm88 617 29 RNA RNA NNP cord-021413-1ht1xm88 618 1 The the DT cord-021413-1ht1xm88 618 2 cellular cellular JJ cord-021413-1ht1xm88 618 3 nature nature NN cord-021413-1ht1xm88 618 4 of of IN cord-021413-1ht1xm88 618 5 genetic genetic JJ cord-021413-1ht1xm88 618 6 susceptibility susceptibility NN cord-021413-1ht1xm88 618 7 to to IN cord-021413-1ht1xm88 618 8 a a DT cord-021413-1ht1xm88 618 9 virus virus NN cord-021413-1ht1xm88 619 1 The the DT cord-021413-1ht1xm88 619 2 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 619 3 Reoviruslike Reoviruslike NNP cord-021413-1ht1xm88 619 4 agent agent NN cord-021413-1ht1xm88 619 5 in in IN cord-021413-1ht1xm88 619 6 stools stool NNS cord-021413-1ht1xm88 619 7 : : : cord-021413-1ht1xm88 619 8 Association Association NNP cord-021413-1ht1xm88 619 9 with with IN cord-021413-1ht1xm88 619 10 infantile infantile JJ cord-021413-1ht1xm88 619 11 diarrhea diarrhea NN cord-021413-1ht1xm88 619 12 and and CC cord-021413-1ht1xm88 619 13 development development NN cord-021413-1ht1xm88 619 14 of of IN cord-021413-1ht1xm88 619 15 serologic serologic JJ cord-021413-1ht1xm88 619 16 tests test NNS cord-021413-1ht1xm88 619 17 Antigentic antigentic JJ cord-021413-1ht1xm88 619 18 relationships relationship NNS cord-021413-1ht1xm88 619 19 among among IN cord-021413-1ht1xm88 619 20 five five CD cord-021413-1ht1xm88 619 21 reovirus reovirus JJ cord-021413-1ht1xm88 619 22 - - HYPH cord-021413-1ht1xm88 619 23 like like JJ cord-021413-1ht1xm88 619 24 agents agent NNS cord-021413-1ht1xm88 619 25 by by IN cord-021413-1ht1xm88 619 26 complement complement NN cord-021413-1ht1xm88 619 27 fixation fixation NN cord-021413-1ht1xm88 619 28 Vertical vertical JJ cord-021413-1ht1xm88 619 29 transmission transmission NN cord-021413-1ht1xm88 619 30 of of IN cord-021413-1ht1xm88 619 31 mouse mouse NN cord-021413-1ht1xm88 619 32 hepatitis hepatitis NN cord-021413-1ht1xm88 619 33 virus virus NN cord-021413-1ht1xm88 619 34 infection infection NN cord-021413-1ht1xm88 619 35 in in IN cord-021413-1ht1xm88 619 36 mice mouse NNS cord-021413-1ht1xm88 620 1 Some some DT cord-021413-1ht1xm88 620 2 characteristics characteristic NNS cord-021413-1ht1xm88 620 3 of of IN cord-021413-1ht1xm88 620 4 hemaggluti hemaggluti NNP cord-021413-1ht1xm88 620 5 nation nation NN cord-021413-1ht1xm88 620 6 of of IN cord-021413-1ht1xm88 620 7 certain certain JJ cord-021413-1ht1xm88 620 8 strains strain NNS cord-021413-1ht1xm88 620 9 of of IN cord-021413-1ht1xm88 620 10 " " `` cord-021413-1ht1xm88 620 11 IBV IBV NNP cord-021413-1ht1xm88 620 12 - - HYPH cord-021413-1ht1xm88 620 13 like like JJ cord-021413-1ht1xm88 620 14 " " '' cord-021413-1ht1xm88 620 15 virus virus NN cord-021413-1ht1xm88 620 16 Studies study NNS cord-021413-1ht1xm88 620 17 on on IN cord-021413-1ht1xm88 620 18 the the DT cord-021413-1ht1xm88 620 19 etiology etiology NN cord-021413-1ht1xm88 620 20 and and CC cord-021413-1ht1xm88 620 21 transmission transmission NN cord-021413-1ht1xm88 620 22 of of IN cord-021413-1ht1xm88 620 23 epidemic epidemic JJ cord-021413-1ht1xm88 620 24 diarrhea diarrhea NN cord-021413-1ht1xm88 620 25 of of IN cord-021413-1ht1xm88 620 26 infant infant NN cord-021413-1ht1xm88 620 27 mice mouse NNS cord-021413-1ht1xm88 620 28 Observations observation NNS cord-021413-1ht1xm88 620 29 on on IN cord-021413-1ht1xm88 620 30 the the DT cord-021413-1ht1xm88 620 31 control control NN cord-021413-1ht1xm88 620 32 and and CC cord-021413-1ht1xm88 620 33 natural natural JJ cord-021413-1ht1xm88 620 34 history history NN cord-021413-1ht1xm88 620 35 of of IN cord-021413-1ht1xm88 620 36 epidemic epidemic JJ cord-021413-1ht1xm88 620 37 diarrhea diarrhea NN cord-021413-1ht1xm88 620 38 of of IN cord-021413-1ht1xm88 620 39 infant infant NN cord-021413-1ht1xm88 620 40 mice mouse NNS cord-021413-1ht1xm88 620 41 ( ( -LRB- cord-021413-1ht1xm88 620 42 EDIM EDIM NNP cord-021413-1ht1xm88 620 43 ) ) -RRB- cord-021413-1ht1xm88 621 1 Responses response NNS cord-021413-1ht1xm88 621 2 of of IN cord-021413-1ht1xm88 621 3 the the DT cord-021413-1ht1xm88 621 4 mouse mouse NN cord-021413-1ht1xm88 621 5 to to IN cord-021413-1ht1xm88 621 6 the the DT cord-021413-1ht1xm88 621 7 virus virus NN cord-021413-1ht1xm88 621 8 of of IN cord-021413-1ht1xm88 621 9 epidemic epidemic JJ cord-021413-1ht1xm88 621 10 diarrhea diarrhea NN cord-021413-1ht1xm88 621 11 of of IN cord-021413-1ht1xm88 621 12 infant infant NN cord-021413-1ht1xm88 621 13 mice mouse NNS cord-021413-1ht1xm88 621 14 . . . cord-021413-1ht1xm88 622 1 Neutralizing neutralize VBG cord-021413-1ht1xm88 622 2 antibodies antibody NNS cord-021413-1ht1xm88 622 3 and and CC cord-021413-1ht1xm88 622 4 carrier carrier NN cord-021413-1ht1xm88 622 5 state state NN cord-021413-1ht1xm88 623 1 Two two CD cord-021413-1ht1xm88 623 2 viruses virus NNS cord-021413-1ht1xm88 623 3 causing cause VBG cord-021413-1ht1xm88 623 4 diarrhea diarrhea NN cord-021413-1ht1xm88 623 5 in in IN cord-021413-1ht1xm88 623 6 infant infant NN cord-021413-1ht1xm88 623 7 mice mouse NNS cord-021413-1ht1xm88 624 1 An an DT cord-021413-1ht1xm88 624 2 apparently apparently RB cord-021413-1ht1xm88 624 3 new new JJ cord-021413-1ht1xm88 624 4 lethal lethal JJ cord-021413-1ht1xm88 624 5 virus virus NN cord-021413-1ht1xm88 624 6 disease disease NN cord-021413-1ht1xm88 624 7 of of IN cord-021413-1ht1xm88 624 8 infant infant NN cord-021413-1ht1xm88 624 9 mice mouse NNS cord-021413-1ht1xm88 624 10 Epizootic epizootic JJ cord-021413-1ht1xm88 624 11 diarrhea diarrhea NN cord-021413-1ht1xm88 624 12 of of IN cord-021413-1ht1xm88 624 13 infant infant NN cord-021413-1ht1xm88 624 14 mice mouse NNS cord-021413-1ht1xm88 624 15 and and CC cord-021413-1ht1xm88 624 16 lethal lethal JJ cord-021413-1ht1xm88 624 17 intestinal intestinal JJ cord-021413-1ht1xm88 624 18 virus virus NN cord-021413-1ht1xm88 624 19 infection infection NN cord-021413-1ht1xm88 624 20 of of IN cord-021413-1ht1xm88 624 21 infant infant NN cord-021413-1ht1xm88 624 22 mice mouse NNS cord-021413-1ht1xm88 624 23 Practical practical JJ cord-021413-1ht1xm88 624 24 control control NN cord-021413-1ht1xm88 624 25 of of IN cord-021413-1ht1xm88 624 26 diarrheal diarrheal JJ cord-021413-1ht1xm88 624 27 disease disease NN cord-021413-1ht1xm88 624 28 in in IN cord-021413-1ht1xm88 624 29 a a DT cord-021413-1ht1xm88 624 30 commercial commercial JJ cord-021413-1ht1xm88 624 31 mouse mouse NN cord-021413-1ht1xm88 624 32 colony colony NN cord-021413-1ht1xm88 624 33 Reovirus Reovirus NNP cord-021413-1ht1xm88 624 34 infection infection NN cord-021413-1ht1xm88 624 35 in in IN cord-021413-1ht1xm88 624 36 suckl suckl NNP cord-021413-1ht1xm88 624 37 ing e VBG cord-021413-1ht1xm88 624 38 mice mouse NNS cord-021413-1ht1xm88 625 1 : : : cord-021413-1ht1xm88 625 2 Immunofluorescent Immunofluorescent NNP cord-021413-1ht1xm88 625 3 and and CC cord-021413-1ht1xm88 625 4 infectivity infectivity NN cord-021413-1ht1xm88 625 5 studies study NNS cord-021413-1ht1xm88 625 6 Discussion Discussion NNP cord-021413-1ht1xm88 625 7 of of IN cord-021413-1ht1xm88 625 8 Kraft Kraft NNP cord-021413-1ht1xm88 625 9 , , , cord-021413-1ht1xm88 626 1 L. L. NNP cord-021413-1ht1xm88 626 2 M. M. NNP cord-021413-1ht1xm88 626 3 Two two CD cord-021413-1ht1xm88 626 4 viruses virus NNS cord-021413-1ht1xm88 626 5 causing cause VBG cord-021413-1ht1xm88 626 6 diarrhea diarrhea NN cord-021413-1ht1xm88 626 7 in in IN cord-021413-1ht1xm88 626 8 infant infant NN cord-021413-1ht1xm88 626 9 mice mouse NNS cord-021413-1ht1xm88 627 1 In in IN cord-021413-1ht1xm88 627 2 vivo vivo NN cord-021413-1ht1xm88 627 3 interference interference NN cord-021413-1ht1xm88 627 4 between between IN cord-021413-1ht1xm88 627 5 heterologous heterologous NNP cord-021413-1ht1xm88 627 6 rotaviruses rotaviruses NNP cord-021413-1ht1xm88 628 1 The the DT cord-021413-1ht1xm88 628 2 induction induction NN cord-021413-1ht1xm88 628 3 of of IN cord-021413-1ht1xm88 628 4 interferon interferon NN cord-021413-1ht1xm88 628 5 by by IN cord-021413-1ht1xm88 628 6 temperature temperature NN cord-021413-1ht1xm88 628 7 - - HYPH cord-021413-1ht1xm88 628 8 sensitive sensitive JJ cord-021413-1ht1xm88 628 9 mutants mutant NNS cord-021413-1ht1xm88 628 10 of of IN cord-021413-1ht1xm88 628 11 reovirus reovirus NNP cord-021413-1ht1xm88 628 12 , , , cord-021413-1ht1xm88 628 13 UV uv NN cord-021413-1ht1xm88 628 14 - - HYPH cord-021413-1ht1xm88 628 15 irradiated irradiate VBN cord-021413-1ht1xm88 628 16 reovirus reovirus NNP cord-021413-1ht1xm88 628 17 , , , cord-021413-1ht1xm88 628 18 and and CC cord-021413-1ht1xm88 628 19 subviral subviral NNP cord-021413-1ht1xm88 628 20 reovirus reovirus NNP cord-021413-1ht1xm88 628 21 particles particle NNS cord-021413-1ht1xm88 628 22 Diagnosis Diagnosis NNP cord-021413-1ht1xm88 628 23 of of IN cord-021413-1ht1xm88 628 24 rotavirus rotavirus NN cord-021413-1ht1xm88 628 25 , , , cord-021413-1ht1xm88 628 26 adenovirus adenovirus NN cord-021413-1ht1xm88 628 27 , , , cord-021413-1ht1xm88 628 28 and and CC cord-021413-1ht1xm88 628 29 heφes heφes JJ cord-021413-1ht1xm88 628 30 virus virus NN cord-021413-1ht1xm88 628 31 infections infection NNS cord-021413-1ht1xm88 628 32 by by IN cord-021413-1ht1xm88 628 33 immune immune JJ cord-021413-1ht1xm88 628 34 electron electron NN cord-021413-1ht1xm88 628 35 microscopy microscopy NN cord-021413-1ht1xm88 628 36 using use VBG cord-021413-1ht1xm88 628 37 a a DT cord-021413-1ht1xm88 628 38 serum serum NN cord-021413-1ht1xm88 628 39 - - HYPH cord-021413-1ht1xm88 628 40 in in IN cord-021413-1ht1xm88 628 41 - - HYPH cord-021413-1ht1xm88 628 42 agar agar NN cord-021413-1ht1xm88 628 43 diffusion diffusion NN cord-021413-1ht1xm88 628 44 method method NN cord-021413-1ht1xm88 628 45 Autoimmune Autoimmune NNP cord-021413-1ht1xm88 628 46 and and CC cord-021413-1ht1xm88 628 47 virus virus NN cord-021413-1ht1xm88 628 48 - - HYPH cord-021413-1ht1xm88 628 49 induced induce VBN cord-021413-1ht1xm88 628 50 demyelinating demyelinate VBG cord-021413-1ht1xm88 628 51 dis dis NN cord-021413-1ht1xm88 628 52 eases ease VBZ cord-021413-1ht1xm88 628 53 Mechanism mechanism NN cord-021413-1ht1xm88 628 54 of of IN cord-021413-1ht1xm88 628 55 demyelination demyelination NN cord-021413-1ht1xm88 628 56 of of IN cord-021413-1ht1xm88 628 57 JHM JHM NNP cord-021413-1ht1xm88 628 58 virus virus NN cord-021413-1ht1xm88 628 59 encephalomyelitis encephalomyelitis NN cord-021413-1ht1xm88 628 60 Untersuchungen Untersuchungen NNP cord-021413-1ht1xm88 628 61 über über XX cord-021413-1ht1xm88 629 1 die die VB cord-021413-1ht1xm88 630 1 Entstehung Entstehung NNP cord-021413-1ht1xm88 630 2 von von NNP cord-021413-1ht1xm88 630 3 Riesenzellen Riesenzellen NNP cord-021413-1ht1xm88 630 4 in in IN cord-021413-1ht1xm88 630 5 Mäusemakrophagenkulturen Mäusemakrophagenkulturen NNP cord-021413-1ht1xm88 630 6 nach nach NNP cord-021413-1ht1xm88 630 7 Infektion Infektion NNP cord-021413-1ht1xm88 630 8 mit mit NNP cord-021413-1ht1xm88 630 9 dem dem NNP cord-021413-1ht1xm88 630 10 Mäusehepatitisvirus Mäusehepatitisvirus NNP cord-021413-1ht1xm88 630 11 ( ( -LRB- cord-021413-1ht1xm88 630 12 MHV-3 MHV-3 NNP cord-021413-1ht1xm88 630 13 ) ) -RRB- cord-021413-1ht1xm88 630 14 Differential differential JJ cord-021413-1ht1xm88 630 15 growth growth NN cord-021413-1ht1xm88 630 16 of of IN cord-021413-1ht1xm88 630 17 MHV(PRI MHV(PRI NNP cord-021413-1ht1xm88 630 18 ) ) -RRB- cord-021413-1ht1xm88 630 19 and and CC cord-021413-1ht1xm88 630 20 MHV(C3H MHV(C3H NNP cord-021413-1ht1xm88 630 21 ) ) -RRB- cord-021413-1ht1xm88 630 22 in in IN cord-021413-1ht1xm88 630 23 genetically genetically RB cord-021413-1ht1xm88 630 24 resistant resistant JJ cord-021413-1ht1xm88 630 25 C3H c3h RB cord-021413-1ht1xm88 630 26 rendered render VBN cord-021413-1ht1xm88 630 27 susceptible susceptible JJ cord-021413-1ht1xm88 630 28 by by IN cord-021413-1ht1xm88 630 29 Eperythrozoon Eperythrozoon NNP cord-021413-1ht1xm88 630 30 coccoides coccoides NNP cord-021413-1ht1xm88 630 31 Relationship relationship NN cord-021413-1ht1xm88 630 32 of of IN cord-021413-1ht1xm88 630 33 phagocytic phagocytic JJ cord-021413-1ht1xm88 630 34 activity activity NN cord-021413-1ht1xm88 630 35 to to IN cord-021413-1ht1xm88 630 36 pathogenicitiy pathogenicitiy NNP cord-021413-1ht1xm88 630 37 of of IN cord-021413-1ht1xm88 630 38 mouse mouse NNP cord-021413-1ht1xm88 630 39 hepatitis hepatitis NNP cord-021413-1ht1xm88 630 40 virus virus NN cord-021413-1ht1xm88 630 41 as as IN cord-021413-1ht1xm88 630 42 affected affect VBN cord-021413-1ht1xm88 630 43 by by IN cord-021413-1ht1xm88 630 44 triolein triolein NNP cord-021413-1ht1xm88 630 45 and and CC cord-021413-1ht1xm88 630 46 cor cor NNP cord-021413-1ht1xm88 630 47 tisone tisone NNP cord-021413-1ht1xm88 630 48 Immunodiffusion Immunodiffusion NNP cord-021413-1ht1xm88 630 49 and and CC cord-021413-1ht1xm88 630 50 immunoelectrophoretic immunoelectrophoretic NNP cord-021413-1ht1xm88 630 51 studies study NNS cord-021413-1ht1xm88 630 52 of of IN cord-021413-1ht1xm88 630 53 reovirus reovirus NNP cord-021413-1ht1xm88 630 54 antigens antigen NNS cord-021413-1ht1xm88 630 55 Immunopathology Immunopathology NNP cord-021413-1ht1xm88 630 56 of of IN cord-021413-1ht1xm88 630 57 mouse mouse NN cord-021413-1ht1xm88 630 58 hepatitis hepatitis NNP cord-021413-1ht1xm88 630 59 virus virus NN cord-021413-1ht1xm88 630 60 type type NN cord-021413-1ht1xm88 630 61 3 3 CD cord-021413-1ht1xm88 630 62 infection infection NN cord-021413-1ht1xm88 630 63 . . . cord-021413-1ht1xm88 631 1 III III NNP cord-021413-1ht1xm88 631 2 . . . cord-021413-1ht1xm88 632 1 Clinical clinical JJ cord-021413-1ht1xm88 632 2 and and CC cord-021413-1ht1xm88 632 3 virologic virologic JJ cord-021413-1ht1xm88 632 4 observation observation NN cord-021413-1ht1xm88 632 5 of of IN cord-021413-1ht1xm88 632 6 a a DT cord-021413-1ht1xm88 632 7 persistent persistent JJ cord-021413-1ht1xm88 632 8 viral viral JJ cord-021413-1ht1xm88 632 9 infection infection NN cord-021413-1ht1xm88 632 10 Immunopathology immunopathology NN cord-021413-1ht1xm88 632 11 of of IN cord-021413-1ht1xm88 632 12 mouse mouse NN cord-021413-1ht1xm88 632 13 hepatitis hepatitis NNP cord-021413-1ht1xm88 632 14 virus virus NN cord-021413-1ht1xm88 632 15 type type NN cord-021413-1ht1xm88 632 16 3 3 CD cord-021413-1ht1xm88 632 17 infection infection NN cord-021413-1ht1xm88 632 18 . . . cord-021413-1ht1xm88 633 1 I. I. NNP cord-021413-1ht1xm88 633 2 Role role NN cord-021413-1ht1xm88 633 3 of of IN cord-021413-1ht1xm88 633 4 humoral humoral JJ cord-021413-1ht1xm88 633 5 and and CC cord-021413-1ht1xm88 633 6 cell cell NN cord-021413-1ht1xm88 633 7 - - HYPH cord-021413-1ht1xm88 633 8 mediated mediate VBN cord-021413-1ht1xm88 633 9 immunity immunity NN cord-021413-1ht1xm88 633 10 in in IN cord-021413-1ht1xm88 633 11 resistance resistance NN cord-021413-1ht1xm88 633 12 mechanisms mechanism NNS cord-021413-1ht1xm88 633 13 Neonatal neonatal JJ cord-021413-1ht1xm88 633 14 susceptibility susceptibility NN cord-021413-1ht1xm88 633 15 to to IN cord-021413-1ht1xm88 633 16 MHV3 MHV3 NNP cord-021413-1ht1xm88 633 17 infection infection NN cord-021413-1ht1xm88 633 18 in in IN cord-021413-1ht1xm88 633 19 mice mouse NNS cord-021413-1ht1xm88 633 20 . . . cord-021413-1ht1xm88 634 1 I. I. NNP cord-021413-1ht1xm88 634 2 Transfer transfer NN cord-021413-1ht1xm88 634 3 of of IN cord-021413-1ht1xm88 634 4 resistance resistance NN cord-021413-1ht1xm88 634 5 Genetic genetic JJ cord-021413-1ht1xm88 634 6 study study NN cord-021413-1ht1xm88 634 7 of of IN cord-021413-1ht1xm88 634 8 mouse mouse NN cord-021413-1ht1xm88 634 9 sensitivity sensitivity NN cord-021413-1ht1xm88 634 10 to to IN cord-021413-1ht1xm88 634 11 MHV3 MHV3 NNP cord-021413-1ht1xm88 634 12 infection infection NN cord-021413-1ht1xm88 634 13 : : : cord-021413-1ht1xm88 635 1 Influence influence NN cord-021413-1ht1xm88 635 2 of of IN cord-021413-1ht1xm88 635 3 the the DT cord-021413-1ht1xm88 635 4 H-2 H-2 NNP cord-021413-1ht1xm88 635 5 complex complex JJ cord-021413-1ht1xm88 635 6 Polykaryocytosis Polykaryocytosis NNP cord-021413-1ht1xm88 635 7 and and CC cord-021413-1ht1xm88 635 8 replication replication NN cord-021413-1ht1xm88 635 9 of of IN cord-021413-1ht1xm88 635 10 mouse mouse NN cord-021413-1ht1xm88 635 11 hepatitis hepatitis NN cord-021413-1ht1xm88 635 12 virus virus NN cord-021413-1ht1xm88 635 13 in in IN cord-021413-1ht1xm88 635 14 peritoneal peritoneal JJ cord-021413-1ht1xm88 635 15 macrophages macrophage NNS cord-021413-1ht1xm88 635 16 In in IN cord-021413-1ht1xm88 635 17 vivo vivo NN cord-021413-1ht1xm88 635 18 and and CC cord-021413-1ht1xm88 635 19 in in IN cord-021413-1ht1xm88 635 20 vitro vitro FW cord-021413-1ht1xm88 635 21 models model NNS cord-021413-1ht1xm88 635 22 of of IN cord-021413-1ht1xm88 635 23 demyelinating demyelinate VBG cord-021413-1ht1xm88 635 24 diseases disease NNS cord-021413-1ht1xm88 635 25 : : : cord-021413-1ht1xm88 635 26 tropism tropism NN cord-021413-1ht1xm88 635 27 of of IN cord-021413-1ht1xm88 635 28 the the DT cord-021413-1ht1xm88 635 29 JHM JHM NNP cord-021413-1ht1xm88 635 30 strain strain NN cord-021413-1ht1xm88 635 31 of of IN cord-021413-1ht1xm88 635 32 murine murine JJ cord-021413-1ht1xm88 635 33 hepatitis hepatitis NN cord-021413-1ht1xm88 635 34 virus virus NN cord-021413-1ht1xm88 635 35 for for IN cord-021413-1ht1xm88 635 36 cells cell NNS cord-021413-1ht1xm88 635 37 of of IN cord-021413-1ht1xm88 635 38 glial glial JJ cord-021413-1ht1xm88 635 39 origin origin NN cord-021413-1ht1xm88 636 1 An an DT cord-021413-1ht1xm88 636 2 ultrastructural ultrastructural JJ cord-021413-1ht1xm88 636 3 study study NN cord-021413-1ht1xm88 636 4 of of IN cord-021413-1ht1xm88 636 5 virions virion NNS cord-021413-1ht1xm88 636 6 and and CC cord-021413-1ht1xm88 636 7 cores core NNS cord-021413-1ht1xm88 636 8 of of IN cord-021413-1ht1xm88 636 9 reovirus reovirus NNP cord-021413-1ht1xm88 636 10 type type NN cord-021413-1ht1xm88 636 11 3 3 CD cord-021413-1ht1xm88 636 12 Infectivity infectivity NN cord-021413-1ht1xm88 636 13 assay assay NN cord-021413-1ht1xm88 636 14 of of IN cord-021413-1ht1xm88 636 15 reoviruses reovirus NNS cord-021413-1ht1xm88 636 16 : : : cord-021413-1ht1xm88 636 17 Comparison comparison NN cord-021413-1ht1xm88 636 18 of of IN cord-021413-1ht1xm88 636 19 immunofluorescent immunofluorescent JJ cord-021413-1ht1xm88 636 20 cell cell NN cord-021413-1ht1xm88 636 21 count count NN cord-021413-1ht1xm88 636 22 and and CC cord-021413-1ht1xm88 636 23 plaque plaque NN cord-021413-1ht1xm88 636 24 methods method NNS cord-021413-1ht1xm88 637 1 The the DT cord-021413-1ht1xm88 637 2 digestive digestive JJ cord-021413-1ht1xm88 637 3 system system NN cord-021413-1ht1xm88 638 1 The the DT cord-021413-1ht1xm88 638 2 nature nature NN cord-021413-1ht1xm88 638 3 of of IN cord-021413-1ht1xm88 638 4 the the DT cord-021413-1ht1xm88 638 5 polypeptide polypeptide NN cord-021413-1ht1xm88 638 6 encoded encode VBN cord-021413-1ht1xm88 638 7 by by IN cord-021413-1ht1xm88 638 8 each each DT cord-021413-1ht1xm88 638 9 of of IN cord-021413-1ht1xm88 638 10 the the DT cord-021413-1ht1xm88 638 11 10 10 CD cord-021413-1ht1xm88 638 12 double double RB cord-021413-1ht1xm88 638 13 - - HYPH cord-021413-1ht1xm88 638 14 stranded strand VBN cord-021413-1ht1xm88 638 15 segments segment NNS cord-021413-1ht1xm88 638 16 of of IN cord-021413-1ht1xm88 638 17 reovirus reovirus NNP cord-021413-1ht1xm88 638 18 type type NN cord-021413-1ht1xm88 638 19 3 3 CD cord-021413-1ht1xm88 638 20 Trans trans JJ cord-021413-1ht1xm88 638 21 - - JJ cord-021413-1ht1xm88 638 22 stadial stadial JJ cord-021413-1ht1xm88 638 23 maintenance maintenance NN cord-021413-1ht1xm88 638 24 of of IN cord-021413-1ht1xm88 638 25 reovirus reovirus NNP cord-021413-1ht1xm88 638 26 type type NNP cord-021413-1ht1xm88 638 27 3 3 CD cord-021413-1ht1xm88 638 28 in in IN cord-021413-1ht1xm88 638 29 the the DT cord-021413-1ht1xm88 638 30 mosquito mosquito NN cord-021413-1ht1xm88 639 1 Culex Culex NNP cord-021413-1ht1xm88 639 2 pipiens pipien VBZ cord-021413-1ht1xm88 639 3 fatigans fatigans NNP cord-021413-1ht1xm88 639 4 Weidmann Weidmann NNP cord-021413-1ht1xm88 639 5 and and CC cord-021413-1ht1xm88 639 6 its -PRON- PRP$ cord-021413-1ht1xm88 639 7 implications implication NNS cord-021413-1ht1xm88 639 8 Coronaviruses Coronaviruses NNP cord-021413-1ht1xm88 639 9 : : : cord-021413-1ht1xm88 640 1 A a DT cord-021413-1ht1xm88 640 2 comparative comparative JJ cord-021413-1ht1xm88 640 3 review review NN cord-021413-1ht1xm88 640 4 Coronaviruses Coronaviruses NNPS cord-021413-1ht1xm88 640 5 as as IN cord-021413-1ht1xm88 640 6 causes cause NNS cord-021413-1ht1xm88 640 7 of of IN cord-021413-1ht1xm88 640 8 diseases disease NNS cord-021413-1ht1xm88 640 9 : : : cord-021413-1ht1xm88 641 1 Clinical clinical JJ cord-021413-1ht1xm88 641 2 observa observa NNP cord-021413-1ht1xm88 641 3 tions tion NNS cord-021413-1ht1xm88 641 4 and and CC cord-021413-1ht1xm88 641 5 diagnosis diagnosis NN cord-021413-1ht1xm88 641 6 Growth growth NN cord-021413-1ht1xm88 641 7 in in IN cord-021413-1ht1xm88 641 8 suckling suckle VBG cord-021413-1ht1xm88 641 9 - - HYPH cord-021413-1ht1xm88 641 10 mouse mouse NN cord-021413-1ht1xm88 641 11 brain brain NN cord-021413-1ht1xm88 641 12 of of IN cord-021413-1ht1xm88 641 13 " " `` cord-021413-1ht1xm88 641 14 IBV IBV NNP cord-021413-1ht1xm88 641 15 - - HYPH cord-021413-1ht1xm88 641 16 like like JJ cord-021413-1ht1xm88 641 17 " " '' cord-021413-1ht1xm88 641 18 viruses virus NNS cord-021413-1ht1xm88 641 19 from from IN cord-021413-1ht1xm88 641 20 patients patient NNS cord-021413-1ht1xm88 641 21 with with IN cord-021413-1ht1xm88 641 22 upper upper JJ cord-021413-1ht1xm88 641 23 respiratory respiratory JJ cord-021413-1ht1xm88 641 24 tract tract NN cord-021413-1ht1xm88 641 25 disease disease NN cord-021413-1ht1xm88 641 26 Antigenic antigenic JJ cord-021413-1ht1xm88 641 27 relationships relationship NNS cord-021413-1ht1xm88 641 28 among among IN cord-021413-1ht1xm88 641 29 the the DT cord-021413-1ht1xm88 641 30 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 641 31 of of IN cord-021413-1ht1xm88 641 32 man man NN cord-021413-1ht1xm88 641 33 and and CC cord-021413-1ht1xm88 641 34 between between IN cord-021413-1ht1xm88 641 35 human human JJ cord-021413-1ht1xm88 641 36 and and CC cord-021413-1ht1xm88 641 37 animal animal NN cord-021413-1ht1xm88 641 38 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 642 1 The the DT cord-021413-1ht1xm88 642 2 polypeptides polypeptide NNS cord-021413-1ht1xm88 642 3 of of IN cord-021413-1ht1xm88 643 1 human human JJ cord-021413-1ht1xm88 643 2 and and CC cord-021413-1ht1xm88 643 3 mouse mouse NN cord-021413-1ht1xm88 643 4 coronaviruses coronaviruses NNPS cord-021413-1ht1xm88 643 5 Rotaviruses Rotaviruses NNP cord-021413-1ht1xm88 643 6 - - : cord-021413-1ht1xm88 643 7 a a DT cord-021413-1ht1xm88 643 8 review review NN cord-021413-1ht1xm88 643 9 Moφhology moφhology NN cord-021413-1ht1xm88 643 10 and and CC cord-021413-1ht1xm88 643 11 chemical chemical JJ cord-021413-1ht1xm88 643 12 composition composition NN cord-021413-1ht1xm88 643 13 of of IN cord-021413-1ht1xm88 643 14 rotaviruses rotaviruses NNP cord-021413-1ht1xm88 643 15 Observations Observations NNP cord-021413-1ht1xm88 643 16 on on IN cord-021413-1ht1xm88 643 17 the the DT cord-021413-1ht1xm88 643 18 growth growth NN cord-021413-1ht1xm88 643 19 of of IN cord-021413-1ht1xm88 643 20 mouse mouse NN cord-021413-1ht1xm88 643 21 hepatitis hepatitis NN cord-021413-1ht1xm88 643 22 virus virus NN cord-021413-1ht1xm88 643 23 ( ( -LRB- cord-021413-1ht1xm88 643 24 MHV-3 MHV-3 NNP cord-021413-1ht1xm88 643 25 ) ) -RRB- cord-021413-1ht1xm88 643 26 in in IN cord-021413-1ht1xm88 643 27 mouse mouse NN cord-021413-1ht1xm88 643 28 macrophages macrophage NNS cord-021413-1ht1xm88 643 29 A. A. NNP cord-021413-1ht1xm88 643 30 hepatitis hepatitis NN cord-021413-1ht1xm88 643 31 virus virus NN cord-021413-1ht1xm88 643 32 complicating complicate VBG cord-021413-1ht1xm88 643 33 studies study NNS cord-021413-1ht1xm88 643 34 with with IN cord-021413-1ht1xm88 643 35 mouse mouse NN cord-021413-1ht1xm88 643 36 leukemia leukemia NN cord-021413-1ht1xm88 643 37 Identity identity NN cord-021413-1ht1xm88 643 38 of of IN cord-021413-1ht1xm88 643 39 Cowdry Cowdry NNP cord-021413-1ht1xm88 643 40 type type NN cord-021413-1ht1xm88 643 41 Β β NN cord-021413-1ht1xm88 643 42 inclusions inclusion NNS cord-021413-1ht1xm88 643 43 and and CC cord-021413-1ht1xm88 643 44 nuclear nuclear JJ cord-021413-1ht1xm88 643 45 bodies body NNS cord-021413-1ht1xm88 643 46 : : : cord-021413-1ht1xm88 643 47 observations observation NNS cord-021413-1ht1xm88 643 48 in in IN cord-021413-1ht1xm88 643 49 reovirus reovirus NNP cord-021413-1ht1xm88 643 50 encephalitis encephalitis RB cord-021413-1ht1xm88 644 1 An an DT cord-021413-1ht1xm88 644 2 antigenic antigenic JJ cord-021413-1ht1xm88 644 3 subunit subunit NN cord-021413-1ht1xm88 644 4 pre pre VBD cord-021413-1ht1xm88 644 5 sent send VBN cord-021413-1ht1xm88 644 6 in in IN cord-021413-1ht1xm88 644 7 rotavirus rotavirus JJ cord-021413-1ht1xm88 644 8 infected infect VBN cord-021413-1ht1xm88 644 9 faeces faece NNS cord-021413-1ht1xm88 644 10 Plaque Plaque NNP cord-021413-1ht1xm88 644 11 assay assay NN cord-021413-1ht1xm88 644 12 of of IN cord-021413-1ht1xm88 644 13 neonatal neonatal JJ cord-021413-1ht1xm88 644 14 calf calf NN cord-021413-1ht1xm88 644 15 diarrhoea diarrhoea NN cord-021413-1ht1xm88 644 16 and and CC cord-021413-1ht1xm88 644 17 the the DT cord-021413-1ht1xm88 644 18 neutralising neutralise VBG cord-021413-1ht1xm88 644 19 antibody antibody NN cord-021413-1ht1xm88 644 20 in in IN cord-021413-1ht1xm88 644 21 human human JJ cord-021413-1ht1xm88 644 22 sera sera NNP cord-021413-1ht1xm88 645 1 The the DT cord-021413-1ht1xm88 645 2 classification classification NN cord-021413-1ht1xm88 645 3 and and CC cord-021413-1ht1xm88 645 4 nomenclature nomenclature NN cord-021413-1ht1xm88 645 5 of of IN cord-021413-1ht1xm88 645 6 viruses virus NNS cord-021413-1ht1xm88 645 7 Calf calf NN cord-021413-1ht1xm88 645 8 diarrhea diarrhea NN cord-021413-1ht1xm88 645 9 ( ( -LRB- cord-021413-1ht1xm88 645 10 scours scour NNS cord-021413-1ht1xm88 645 11 ) ) -RRB- cord-021413-1ht1xm88 645 12 reproduced reproduce VBN cord-021413-1ht1xm88 645 13 with with IN cord-021413-1ht1xm88 645 14 a a DT cord-021413-1ht1xm88 645 15 virus virus NN cord-021413-1ht1xm88 645 16 from from IN cord-021413-1ht1xm88 645 17 a a DT cord-021413-1ht1xm88 645 18 field field NN cord-021413-1ht1xm88 645 19 outbreak outbreak NN cord-021413-1ht1xm88 645 20 Taxonomy taxonomy NN cord-021413-1ht1xm88 645 21 of of IN cord-021413-1ht1xm88 645 22 viruses virus NNS cord-021413-1ht1xm88 646 1 A a DT cord-021413-1ht1xm88 646 2 reo reo NN cord-021413-1ht1xm88 646 3 - - HYPH cord-021413-1ht1xm88 646 4 like like JJ cord-021413-1ht1xm88 646 5 virus virus NN cord-021413-1ht1xm88 646 6 isolated isolate VBN cord-021413-1ht1xm88 646 7 from from IN cord-021413-1ht1xm88 646 8 juvenile juvenile JJ cord-021413-1ht1xm88 646 9 American american JJ cord-021413-1ht1xm88 646 10 oys oys JJ cord-021413-1ht1xm88 646 11 ters ter NNS cord-021413-1ht1xm88 646 12 ( ( -LRB- cord-021413-1ht1xm88 646 13 Crassostrea Crassostrea NNP cord-021413-1ht1xm88 646 14 virginica virginica NNP cord-021413-1ht1xm88 646 15 ) ) -RRB- cord-021413-1ht1xm88 647 1 Moφhology moφhology NN cord-021413-1ht1xm88 647 2 of of IN cord-021413-1ht1xm88 647 3 a a DT cord-021413-1ht1xm88 647 4 reo reo NNP cord-021413-1ht1xm88 647 5 - - HYPH cord-021413-1ht1xm88 647 6 like like JJ cord-021413-1ht1xm88 647 7 virus virus NN cord-021413-1ht1xm88 647 8 isolated isolate VBN cord-021413-1ht1xm88 647 9 from from IN cord-021413-1ht1xm88 647 10 juvenile juvenile JJ cord-021413-1ht1xm88 647 11 American american JJ cord-021413-1ht1xm88 647 12 oysters oyster NNS cord-021413-1ht1xm88 647 13 ( ( -LRB- cord-021413-1ht1xm88 647 14 Crassostrea Crassostrea NNP cord-021413-1ht1xm88 647 15 virginica virginica NNP cord-021413-1ht1xm88 647 16 ) ) -RRB- cord-021413-1ht1xm88 648 1 Pathogenesis pathogenesis NN cord-021413-1ht1xm88 648 2 of of IN cord-021413-1ht1xm88 648 3 rotaviral rotaviral JJ cord-021413-1ht1xm88 648 4 infection infection NN cord-021413-1ht1xm88 648 5 Counter Counter NNP cord-021413-1ht1xm88 648 6 - - HYPH cord-021413-1ht1xm88 648 7 immunoelectro immunoelectro NNP cord-021413-1ht1xm88 648 8 - - HYPH cord-021413-1ht1xm88 648 9 osmophoresis osmophoresis NNP cord-021413-1ht1xm88 648 10 for for IN cord-021413-1ht1xm88 648 11 the the DT cord-021413-1ht1xm88 648 12 detection detection NN cord-021413-1ht1xm88 648 13 of of IN cord-021413-1ht1xm88 648 14 infantile infantile JJ cord-021413-1ht1xm88 648 15 gastroenteritis gastroenteritis NN cord-021413-1ht1xm88 648 16 virus virus NN cord-021413-1ht1xm88 648 17 ( ( -LRB- cord-021413-1ht1xm88 648 18 orbi orbi NNP cord-021413-1ht1xm88 648 19 - - HYPH cord-021413-1ht1xm88 648 20 group group NN cord-021413-1ht1xm88 648 21 ) ) -RRB- cord-021413-1ht1xm88 648 22 antigen antigen NN cord-021413-1ht1xm88 648 23 and and CC cord-021413-1ht1xm88 648 24 antibody antibody NN cord-021413-1ht1xm88 648 25 Solid solid JJ cord-021413-1ht1xm88 648 26 phase phase NN cord-021413-1ht1xm88 648 27 radioimmunoassay radioimmunoassay JJ cord-021413-1ht1xm88 648 28 for for IN cord-021413-1ht1xm88 648 29 the the DT cord-021413-1ht1xm88 648 30 detection detection NN cord-021413-1ht1xm88 648 31 of of IN cord-021413-1ht1xm88 648 32 rotavirus rotavirus JJ cord-021413-1ht1xm88 648 33 Experimental experimental JJ cord-021413-1ht1xm88 648 34 studies study NNS cord-021413-1ht1xm88 648 35 on on IN cord-021413-1ht1xm88 648 36 hepatitis hepatitis NN cord-021413-1ht1xm88 648 37 virus virus NN cord-021413-1ht1xm88 648 38 of of IN cord-021413-1ht1xm88 648 39 mice mouse NNS cord-021413-1ht1xm88 648 40 in in IN cord-021413-1ht1xm88 648 41 tissue tissue NN cord-021413-1ht1xm88 648 42 culture culture NN cord-021413-1ht1xm88 648 43 Mechanisms Mechanisms NNPS cord-021413-1ht1xm88 648 44 in in IN cord-021413-1ht1xm88 648 45 the the DT cord-021413-1ht1xm88 648 46 pathogenesis pathogenesis NN cord-021413-1ht1xm88 648 47 of of IN cord-021413-1ht1xm88 648 48 diarrhea diarrhea NN cord-021413-1ht1xm88 648 49 : : : cord-021413-1ht1xm88 648 50 a a DT cord-021413-1ht1xm88 648 51 review review NN cord-021413-1ht1xm88 649 1 A a DT cord-021413-1ht1xm88 649 2 new new JJ cord-021413-1ht1xm88 649 3 member member NN cord-021413-1ht1xm88 649 4 of of IN cord-021413-1ht1xm88 649 5 hepatoencephalitis hepatoencephalitis NNP cord-021413-1ht1xm88 649 6 group group NNP cord-021413-1ht1xm88 649 7 of of IN cord-021413-1ht1xm88 649 8 murine murine JJ cord-021413-1ht1xm88 649 9 viruses virus NNS cord-021413-1ht1xm88 649 10 Multiplication multiplication NN cord-021413-1ht1xm88 649 11 and and CC cord-021413-1ht1xm88 649 12 cytopathogenicity cytopathogenicity NN cord-021413-1ht1xm88 649 13 of of IN cord-021413-1ht1xm88 649 14 mouse mouse NNP cord-021413-1ht1xm88 649 15 hepatitis hepatitis NNP cord-021413-1ht1xm88 649 16 virus virus NN cord-021413-1ht1xm88 649 17 in in IN cord-021413-1ht1xm88 649 18 mouse mouse NN cord-021413-1ht1xm88 649 19 cell cell NN cord-021413-1ht1xm88 649 20 cultures culture NNS cord-021413-1ht1xm88 649 21 Purification purification NN cord-021413-1ht1xm88 649 22 and and CC cord-021413-1ht1xm88 649 23 characterization characterization NN cord-021413-1ht1xm88 649 24 of of IN cord-021413-1ht1xm88 649 25 epi epi NNP cord-021413-1ht1xm88 649 26 zootic zootic JJ cord-021413-1ht1xm88 649 27 diarrhea diarrhea NN cord-021413-1ht1xm88 649 28 of of IN cord-021413-1ht1xm88 649 29 infant infant JJ cord-021413-1ht1xm88 649 30 mice mouse NNS cord-021413-1ht1xm88 649 31 virus virus NN cord-021413-1ht1xm88 649 32 Acute acute JJ cord-021413-1ht1xm88 649 33 hepatitis hepatitis NN cord-021413-1ht1xm88 649 34 associated associate VBN cord-021413-1ht1xm88 649 35 with with IN cord-021413-1ht1xm88 649 36 mouse mouse NN cord-021413-1ht1xm88 649 37 leukemia leukemia NN cord-021413-1ht1xm88 649 38 . . . cord-021413-1ht1xm88 650 1 I. I. NNP cord-021413-1ht1xm88 650 2 Etiology etiology NN cord-021413-1ht1xm88 650 3 and and CC cord-021413-1ht1xm88 650 4 host host NN cord-021413-1ht1xm88 650 5 range range NN cord-021413-1ht1xm88 650 6 of of IN cord-021413-1ht1xm88 650 7 the the DT cord-021413-1ht1xm88 650 8 causal causal JJ cord-021413-1ht1xm88 650 9 agent agent NN cord-021413-1ht1xm88 650 10 in in IN cord-021413-1ht1xm88 650 11 mice mouse NNS cord-021413-1ht1xm88 651 1 Acute acute JJ cord-021413-1ht1xm88 651 2 hepatitis hepatitis NN cord-021413-1ht1xm88 651 3 associated associate VBN cord-021413-1ht1xm88 651 4 with with IN cord-021413-1ht1xm88 651 5 mouse mouse NN cord-021413-1ht1xm88 651 6 leukemia leukemia NN cord-021413-1ht1xm88 651 7 . . . cord-021413-1ht1xm88 652 1 I. I. NNP cord-021413-1ht1xm88 652 2 Pathological pathological JJ cord-021413-1ht1xm88 652 3 features feature NNS cord-021413-1ht1xm88 652 4 and and CC cord-021413-1ht1xm88 652 5 transmission transmission NN cord-021413-1ht1xm88 652 6 of of IN cord-021413-1ht1xm88 652 7 the the DT cord-021413-1ht1xm88 652 8 disease disease NN cord-021413-1ht1xm88 652 9 Acute Acute NNP cord-021413-1ht1xm88 652 10 hepatitis hepatitis NN cord-021413-1ht1xm88 652 11 associated associate VBN cord-021413-1ht1xm88 652 12 with with IN cord-021413-1ht1xm88 652 13 mouse mouse NN cord-021413-1ht1xm88 652 14 leukemia leukemia NN cord-021413-1ht1xm88 652 15 . . . cord-021413-1ht1xm88 653 1 IV IV NNP cord-021413-1ht1xm88 653 2 . . . cord-021413-1ht1xm88 654 1 The the DT cord-021413-1ht1xm88 654 2 relationship relationship NN cord-021413-1ht1xm88 654 3 of of IN cord-021413-1ht1xm88 654 4 Eperythrozoon Eperythrozoon NNP cord-021413-1ht1xm88 654 5 coccoides coccoides NNP cord-021413-1ht1xm88 654 6 to to IN cord-021413-1ht1xm88 654 7 the the DT cord-021413-1ht1xm88 654 8 hepatitis hepatitis NN cord-021413-1ht1xm88 654 9 virus virus NN cord-021413-1ht1xm88 654 10 of of IN cord-021413-1ht1xm88 654 11 Prince Prince NNP cord-021413-1ht1xm88 654 12 ton ton NN cord-021413-1ht1xm88 654 13 mice mouse NNS cord-021413-1ht1xm88 654 14 Acute acute JJ cord-021413-1ht1xm88 654 15 hepatitis hepatitis NN cord-021413-1ht1xm88 654 16 associated associate VBN cord-021413-1ht1xm88 654 17 with with IN cord-021413-1ht1xm88 654 18 mouse mouse NN cord-021413-1ht1xm88 654 19 leukemia leukemia NN cord-021413-1ht1xm88 654 20 . . . cord-021413-1ht1xm88 655 1 V. V. NNP cord-021413-1ht1xm88 656 1 The the DT cord-021413-1ht1xm88 656 2 neurotropic neurotropic NNP cord-021413-1ht1xm88 656 3 properties property NNS cord-021413-1ht1xm88 656 4 of of IN cord-021413-1ht1xm88 656 5 the the DT cord-021413-1ht1xm88 656 6 causal causal JJ cord-021413-1ht1xm88 656 7 virus virus NN cord-021413-1ht1xm88 656 8 Recovery recovery NN cord-021413-1ht1xm88 656 9 and and CC cord-021413-1ht1xm88 656 10 behavior behavior NN cord-021413-1ht1xm88 656 11 of of IN cord-021413-1ht1xm88 656 12 hepatitis hepatitis NN cord-021413-1ht1xm88 656 13 virus virus NN cord-021413-1ht1xm88 656 14 from from IN cord-021413-1ht1xm88 656 15 Swiss swiss JJ cord-021413-1ht1xm88 656 16 mice mouse NNS cord-021413-1ht1xm88 656 17 injected inject VBN cord-021413-1ht1xm88 656 18 with with IN cord-021413-1ht1xm88 656 19 ascites ascites NN cord-021413-1ht1xm88 656 20 tumor tumor NN cord-021413-1ht1xm88 656 21 Pathogenicity Pathogenicity NNP cord-021413-1ht1xm88 656 22 of of IN cord-021413-1ht1xm88 656 23 murine murine JJ cord-021413-1ht1xm88 656 24 hepatitis hepatitis NN cord-021413-1ht1xm88 656 25 virus virus NN cord-021413-1ht1xm88 656 26 recovered recover VBN cord-021413-1ht1xm88 656 27 from from IN cord-021413-1ht1xm88 656 28 infant infant JJ cord-021413-1ht1xm88 656 29 Swiss swiss JJ cord-021413-1ht1xm88 656 30 mice mouse NNS cord-021413-1ht1xm88 657 1 An an DT cord-021413-1ht1xm88 657 2 oncolytic oncolytic JJ cord-021413-1ht1xm88 657 3 virus virus NN cord-021413-1ht1xm88 657 4 recovered recover VBN cord-021413-1ht1xm88 657 5 from from IN cord-021413-1ht1xm88 657 6 Swiss swiss JJ cord-021413-1ht1xm88 657 7 mice mouse NNS cord-021413-1ht1xm88 657 8 during during IN cord-021413-1ht1xm88 657 9 passage passage NN cord-021413-1ht1xm88 657 10 of of IN cord-021413-1ht1xm88 657 11 an an DT cord-021413-1ht1xm88 657 12 ascites ascites NN cord-021413-1ht1xm88 657 13 tumour tumour NN cord-021413-1ht1xm88 657 14 Anomalous anomalous JJ cord-021413-1ht1xm88 657 15 high high JJ cord-021413-1ht1xm88 657 16 native native JJ cord-021413-1ht1xm88 657 17 resistance resistance NN cord-021413-1ht1xm88 657 18 of of IN cord-021413-1ht1xm88 657 19 athymic athymic JJ cord-021413-1ht1xm88 657 20 mice mouse NNS cord-021413-1ht1xm88 657 21 to to IN cord-021413-1ht1xm88 657 22 bacterial bacterial JJ cord-021413-1ht1xm88 657 23 pathogens pathogen NNS cord-021413-1ht1xm88 657 24 Detection detection NN cord-021413-1ht1xm88 657 25 of of IN cord-021413-1ht1xm88 657 26 rotavirus rotavirus NN cord-021413-1ht1xm88 657 27 by by IN cord-021413-1ht1xm88 657 28 serological serological JJ cord-021413-1ht1xm88 657 29 trapping trap VBG cord-021413-1ht1xm88 657 30 on on IN cord-021413-1ht1xm88 657 31 antibody antibody NN cord-021413-1ht1xm88 657 32 - - HYPH cord-021413-1ht1xm88 657 33 coated coated JJ cord-021413-1ht1xm88 657 34 electron electron NN cord-021413-1ht1xm88 657 35 micro micro JJ cord-021413-1ht1xm88 657 36 scope scope NN cord-021413-1ht1xm88 657 37 grids grid NNS cord-021413-1ht1xm88 658 1 Further further JJ cord-021413-1ht1xm88 658 2 light light NN cord-021413-1ht1xm88 658 3 on on IN cord-021413-1ht1xm88 658 4 mouse mouse NN cord-021413-1ht1xm88 658 5 hepatitis hepatitis NN cord-021413-1ht1xm88 658 6 Defective defective JJ cord-021413-1ht1xm88 658 7 virions virion NNS cord-021413-1ht1xm88 658 8 of of IN cord-021413-1ht1xm88 658 9 reovirus reovirus NNP cord-021413-1ht1xm88 658 10 Virusinduced Virusinduced NNP cord-021413-1ht1xm88 658 11 diabetes diabete VBZ cord-021413-1ht1xm88 658 12 mellitus mellitus NN cord-021413-1ht1xm88 658 13 : : : cord-021413-1ht1xm88 658 14 reovirus reovirus NNP cord-021413-1ht1xm88 658 15 infection infection NN cord-021413-1ht1xm88 658 16 of of IN cord-021413-1ht1xm88 658 17 pancreatic pancreatic NN cord-021413-1ht1xm88 658 18 /3-cells /3-cell NNS cord-021413-1ht1xm88 658 19 in in IN cord-021413-1ht1xm88 658 20 mice mouse NNS cord-021413-1ht1xm88 658 21 Electron Electron NNP cord-021413-1ht1xm88 658 22 micrographic micrographic NN cord-021413-1ht1xm88 658 23 features feature NNS cord-021413-1ht1xm88 658 24 of of IN cord-021413-1ht1xm88 658 25 acute acute JJ cord-021413-1ht1xm88 658 26 murine murine JJ cord-021413-1ht1xm88 658 27 reovirus reovirus NNP cord-021413-1ht1xm88 658 28 hepatitis hepatitis NN cord-021413-1ht1xm88 658 29 Ultrastructural Ultrastructural NNP cord-021413-1ht1xm88 658 30 features feature NNS cord-021413-1ht1xm88 658 31 of of IN cord-021413-1ht1xm88 658 32 chronic chronic JJ cord-021413-1ht1xm88 658 33 murine murine JJ cord-021413-1ht1xm88 658 34 hepatitis hepatitis NN cord-021413-1ht1xm88 658 35 after after IN cord-021413-1ht1xm88 658 36 reovirus reovirus NNP cord-021413-1ht1xm88 658 37 type type NN cord-021413-1ht1xm88 658 38 3 3 CD cord-021413-1ht1xm88 658 39 infection infection NN cord-021413-1ht1xm88 659 1 An an DT cord-021413-1ht1xm88 659 2 electron electron NN cord-021413-1ht1xm88 659 3 microscopic microscopic JJ cord-021413-1ht1xm88 659 4 study study NN cord-021413-1ht1xm88 659 5 of of IN cord-021413-1ht1xm88 659 6 murine murine JJ cord-021413-1ht1xm88 659 7 reovirus-3 reovirus-3 NNP cord-021413-1ht1xm88 659 8 encephalitis encephalitis RB cord-021413-1ht1xm88 660 1 The the DT cord-021413-1ht1xm88 660 2 biliary biliary JJ cord-021413-1ht1xm88 660 3 tract tract NN cord-021413-1ht1xm88 660 4 in in IN cord-021413-1ht1xm88 660 5 acute acute JJ cord-021413-1ht1xm88 660 6 murine murine JJ cord-021413-1ht1xm88 660 7 reovirus reovirus NN cord-021413-1ht1xm88 660 8 3 3 CD cord-021413-1ht1xm88 660 9 infection infection NN cord-021413-1ht1xm88 660 10 Studies Studies NNPS cord-021413-1ht1xm88 660 11 on on IN cord-021413-1ht1xm88 660 12 the the DT cord-021413-1ht1xm88 660 13 exocrine exocrine JJ cord-021413-1ht1xm88 660 14 pancreas pancrea NNS cord-021413-1ht1xm88 660 15 . . . cord-021413-1ht1xm88 661 1 Π. Π. NNP cord-021413-1ht1xm88 661 2 ultrastructural ultrastructural JJ cord-021413-1ht1xm88 661 3 investigation investigation NN cord-021413-1ht1xm88 661 4 of of IN cord-021413-1ht1xm88 661 5 reovirus reovirus NNP cord-021413-1ht1xm88 661 6 pancreatitis pancreatitis NN cord-021413-1ht1xm88 661 7 Epidemic Epidemic NNP cord-021413-1ht1xm88 661 8 diarrheal diarrheal JJ cord-021413-1ht1xm88 661 9 disease disease NN cord-021413-1ht1xm88 661 10 of of IN cord-021413-1ht1xm88 661 11 suckling suckle VBG cord-021413-1ht1xm88 661 12 mice mouse NNS cord-021413-1ht1xm88 661 13 . . . cord-021413-1ht1xm88 662 1 IV IV NNP cord-021413-1ht1xm88 662 2 . . . cord-021413-1ht1xm88 663 1 Cytoplasmic cytoplasmic JJ cord-021413-1ht1xm88 663 2 inclusion inclusion NN cord-021413-1ht1xm88 663 3 bodies body NNS cord-021413-1ht1xm88 663 4 in in IN cord-021413-1ht1xm88 663 5 intestinal intestinal JJ cord-021413-1ht1xm88 663 6 epithelium epithelium NN cord-021413-1ht1xm88 663 7 in in IN cord-021413-1ht1xm88 663 8 relation relation NN cord-021413-1ht1xm88 663 9 to to IN cord-021413-1ht1xm88 663 10 the the DT cord-021413-1ht1xm88 663 11 disease disease NN cord-021413-1ht1xm88 664 1 An an DT cord-021413-1ht1xm88 664 2 epidemic epidemic NN cord-021413-1ht1xm88 664 3 diarrheal diarrheal JJ cord-021413-1ht1xm88 664 4 dis dis NN cord-021413-1ht1xm88 664 5 ease ease NN cord-021413-1ht1xm88 664 6 of of IN cord-021413-1ht1xm88 664 7 suckling suckle VBG cord-021413-1ht1xm88 664 8 mice mouse NNS cord-021413-1ht1xm88 664 9 . . . cord-021413-1ht1xm88 665 1 II II NNP cord-021413-1ht1xm88 665 2 . . . cord-021413-1ht1xm88 666 1 Inclusions inclusion NNS cord-021413-1ht1xm88 666 2 in in IN cord-021413-1ht1xm88 666 3 the the DT cord-021413-1ht1xm88 666 4 intestinal intestinal JJ cord-021413-1ht1xm88 666 5 epithelial epithelial JJ cord-021413-1ht1xm88 666 6 cells cell NNS cord-021413-1ht1xm88 666 7 Propagation propagation NN cord-021413-1ht1xm88 666 8 of of IN cord-021413-1ht1xm88 666 9 mouse mouse NN cord-021413-1ht1xm88 666 10 hepatitis hepatitis NN cord-021413-1ht1xm88 666 11 virus virus NN cord-021413-1ht1xm88 666 12 ( ( -LRB- cord-021413-1ht1xm88 666 13 MHV-3 MHV-3 NNP cord-021413-1ht1xm88 666 14 ) ) -RRB- cord-021413-1ht1xm88 666 15 in in IN cord-021413-1ht1xm88 666 16 monolayer monolayer NN cord-021413-1ht1xm88 666 17 cell cell NN cord-021413-1ht1xm88 666 18 cultures culture NNS cord-021413-1ht1xm88 666 19 from from IN cord-021413-1ht1xm88 666 20 liver liver NN cord-021413-1ht1xm88 666 21 of of IN cord-021413-1ht1xm88 666 22 newborn newborn JJ cord-021413-1ht1xm88 666 23 mice mouse NNS cord-021413-1ht1xm88 666 24 Virus Virus NNP cord-021413-1ht1xm88 666 25 studies study NNS cord-021413-1ht1xm88 666 26 with with IN cord-021413-1ht1xm88 666 27 germfree germfree NNP cord-021413-1ht1xm88 666 28 mice mouse NNS cord-021413-1ht1xm88 666 29 . . . cord-021413-1ht1xm88 667 1 I. I. NNP cord-021413-1ht1xm88 667 2 Preparation Preparation NNP cord-021413-1ht1xm88 667 3 of of IN cord-021413-1ht1xm88 667 4 serologic serologic NNP cord-021413-1ht1xm88 667 5 diagnostic diagnostic JJ cord-021413-1ht1xm88 667 6 rea rea NNP cord-021413-1ht1xm88 667 7 gents gent NNS cord-021413-1ht1xm88 667 8 and and CC cord-021413-1ht1xm88 667 9 survey survey NN cord-021413-1ht1xm88 667 10 of of IN cord-021413-1ht1xm88 667 11 germfree germfree NNP cord-021413-1ht1xm88 667 12 and and CC cord-021413-1ht1xm88 667 13 monocontaminated monocontaminate VBD cord-021413-1ht1xm88 667 14 mice mice NNP cord-021413-1ht1xm88 667 15 for for IN cord-021413-1ht1xm88 667 16 indige indige NNP cord-021413-1ht1xm88 667 17 nous nous NNP cord-021413-1ht1xm88 667 18 murine murine NN cord-021413-1ht1xm88 667 19 viruses virus NNS cord-021413-1ht1xm88 667 20 Prevalence prevalence NN cord-021413-1ht1xm88 667 21 of of IN cord-021413-1ht1xm88 667 22 viruses virus NNS cord-021413-1ht1xm88 667 23 in in IN cord-021413-1ht1xm88 667 24 mouse mouse NN cord-021413-1ht1xm88 667 25 colonies colony NNS cord-021413-1ht1xm88 667 26 Rat Rat NNP cord-021413-1ht1xm88 667 27 Coronavirus Coronavirus NNP cord-021413-1ht1xm88 667 28 ( ( -LRB- cord-021413-1ht1xm88 667 29 RCV RCV NNP cord-021413-1ht1xm88 667 30 ) ) -RRB- cord-021413-1ht1xm88 667 31 : : : cord-021413-1ht1xm88 668 1 A a DT cord-021413-1ht1xm88 668 2 prevalent prevalent JJ cord-021413-1ht1xm88 668 3 , , , cord-021413-1ht1xm88 668 4 naturally naturally RB cord-021413-1ht1xm88 668 5 occurring occur VBG cord-021413-1ht1xm88 668 6 pneumotropic pneumotropic NNP cord-021413-1ht1xm88 668 7 virus virus NN cord-021413-1ht1xm88 668 8 of of IN cord-021413-1ht1xm88 668 9 rats rat NNS cord-021413-1ht1xm88 669 1 The the DT cord-021413-1ht1xm88 669 2 isolation isolation NN cord-021413-1ht1xm88 669 3 of of IN cord-021413-1ht1xm88 669 4 reovirus reovirus NNP cord-021413-1ht1xm88 669 5 type type NN cord-021413-1ht1xm88 669 6 3 3 CD cord-021413-1ht1xm88 669 7 from from IN cord-021413-1ht1xm88 669 8 mosquitoes mosquito NNS cord-021413-1ht1xm88 669 9 and and CC cord-021413-1ht1xm88 669 10 a a DT cord-021413-1ht1xm88 669 11 sentinel sentinel JJ cord-021413-1ht1xm88 669 12 infant infant NN cord-021413-1ht1xm88 669 13 mouse mouse NN cord-021413-1ht1xm88 669 14 Enzyme Enzyme NNP cord-021413-1ht1xm88 669 15 - - HYPH cord-021413-1ht1xm88 669 16 linked link VBN cord-021413-1ht1xm88 669 17 immunosorbent immunosorbent JJ cord-021413-1ht1xm88 669 18 assay assay NN cord-021413-1ht1xm88 669 19 for for IN cord-021413-1ht1xm88 669 20 detection detection NN cord-021413-1ht1xm88 669 21 of of IN cord-021413-1ht1xm88 669 22 antibodies antibody NNS cord-021413-1ht1xm88 669 23 to to IN cord-021413-1ht1xm88 669 24 murine murine JJ cord-021413-1ht1xm88 669 25 hepatitis hepatitis NN cord-021413-1ht1xm88 669 26 virus virus NN cord-021413-1ht1xm88 669 27 Detection detection NN cord-021413-1ht1xm88 669 28 of of IN cord-021413-1ht1xm88 669 29 neonatal neonatal JJ cord-021413-1ht1xm88 669 30 calf calf NN cord-021413-1ht1xm88 669 31 diarrhea diarrhea NN cord-021413-1ht1xm88 669 32 virus virus NN cord-021413-1ht1xm88 669 33 , , , cord-021413-1ht1xm88 669 34 infant infant NN cord-021413-1ht1xm88 669 35 reovirus reoviru NNS cord-021413-1ht1xm88 669 36 - - HYPH cord-021413-1ht1xm88 669 37 like like JJ cord-021413-1ht1xm88 669 38 diarrhea diarrhea NN cord-021413-1ht1xm88 669 39 virus virus NN cord-021413-1ht1xm88 669 40 , , , cord-021413-1ht1xm88 669 41 and and CC cord-021413-1ht1xm88 669 42 a a DT cord-021413-1ht1xm88 669 43 Coronavirus Coronavirus NNP cord-021413-1ht1xm88 669 44 using use VBG cord-021413-1ht1xm88 669 45 the the DT cord-021413-1ht1xm88 669 46 fluorescent fluorescent JJ cord-021413-1ht1xm88 669 47 virus virus NN cord-021413-1ht1xm88 669 48 precipitin precipitin NNS cord-021413-1ht1xm88 669 49 test test VBP cord-021413-1ht1xm88 669 50 Chronic Chronic NNP cord-021413-1ht1xm88 669 51 obstructive obstructive JJ cord-021413-1ht1xm88 669 52 jaundice jaundice NN cord-021413-1ht1xm88 669 53 induced induce VBN cord-021413-1ht1xm88 669 54 by by IN cord-021413-1ht1xm88 669 55 reovirus reovirus NNP cord-021413-1ht1xm88 669 56 type type NNP cord-021413-1ht1xm88 669 57 3 3 CD cord-021413-1ht1xm88 669 58 in in IN cord-021413-1ht1xm88 669 59 weanling weanle VBG cord-021413-1ht1xm88 669 60 mice mouse NNS cord-021413-1ht1xm88 669 61 Experimental experimental JJ cord-021413-1ht1xm88 669 62 Viral Viral NNP cord-021413-1ht1xm88 669 63 Hepatitis Hepatitis NNP cord-021413-1ht1xm88 670 1 The the DT cord-021413-1ht1xm88 670 2 fate fate NN cord-021413-1ht1xm88 670 3 of of IN cord-021413-1ht1xm88 670 4 murine murine JJ cord-021413-1ht1xm88 670 5 hepatitis hepatitis NN cord-021413-1ht1xm88 670 6 virus virus NN cord-021413-1ht1xm88 670 7 ( ( -LRB- cord-021413-1ht1xm88 670 8 MHV-3 MHV-3 NNP cord-021413-1ht1xm88 670 9 ) ) -RRB- cord-021413-1ht1xm88 670 10 after after IN cord-021413-1ht1xm88 670 11 intravenous intravenous JJ cord-021413-1ht1xm88 670 12 injection injection NN cord-021413-1ht1xm88 670 13 into into IN cord-021413-1ht1xm88 670 14 susceptible susceptible JJ cord-021413-1ht1xm88 670 15 mice mouse NNS cord-021413-1ht1xm88 671 1 Lack lack NN cord-021413-1ht1xm88 671 2 of of IN cord-021413-1ht1xm88 671 3 transplacental transplacental JJ cord-021413-1ht1xm88 671 4 transmissibility transmissibility NN cord-021413-1ht1xm88 671 5 of of IN cord-021413-1ht1xm88 671 6 MHV-3 MHV-3 NNP cord-021413-1ht1xm88 671 7 virus virus NN cord-021413-1ht1xm88 671 8 Oligodendrocytes Oligodendrocytes NNPS cord-021413-1ht1xm88 671 9 and and CC cord-021413-1ht1xm88 671 10 their -PRON- PRP$ cord-021413-1ht1xm88 671 11 myelin myelin NN cord-021413-1ht1xm88 671 12 - - HYPH cord-021413-1ht1xm88 671 13 plasma plasma NN cord-021413-1ht1xm88 671 14 membrane membrane NN cord-021413-1ht1xm88 671 15 connections connection NNS cord-021413-1ht1xm88 671 16 in in IN cord-021413-1ht1xm88 671 17 JHM JHM NNP cord-021413-1ht1xm88 671 18 mouse mouse NN cord-021413-1ht1xm88 671 19 hepatitis hepatitis NNP cord-021413-1ht1xm88 671 20 virus virus NN cord-021413-1ht1xm88 671 21 encephalomyelitis encephalomyelitis NN cord-021413-1ht1xm88 671 22 Proteolytic Proteolytic NNP cord-021413-1ht1xm88 671 23 enzymes enzyme NNS cord-021413-1ht1xm88 671 24 and and CC cord-021413-1ht1xm88 671 25 rotavirus rotavirus JJ cord-021413-1ht1xm88 671 26 SA-11 SA-11 NNP cord-021413-1ht1xm88 671 27 plaque plaque NN cord-021413-1ht1xm88 671 28 formation formation NN cord-021413-1ht1xm88 671 29 A a DT cord-021413-1ht1xm88 671 30 genetic genetic JJ cord-021413-1ht1xm88 671 31 map map NN cord-021413-1ht1xm88 671 32 of of IN cord-021413-1ht1xm88 671 33 reovirus reovirus NNP cord-021413-1ht1xm88 671 34 . . . cord-021413-1ht1xm88 672 1 II II NNP cord-021413-1ht1xm88 672 2 . . . cord-021413-1ht1xm88 673 1 Assignment assignment NN cord-021413-1ht1xm88 673 2 of of IN cord-021413-1ht1xm88 673 3 the the DT cord-021413-1ht1xm88 673 4 double double RB cord-021413-1ht1xm88 673 5 - - HYPH cord-021413-1ht1xm88 673 6 stranded stranded JJ cord-021413-1ht1xm88 673 7 RNAnegative rnanegative NN cord-021413-1ht1xm88 673 8 mutant mutant JJ cord-021413-1ht1xm88 673 9 groups group NNS cord-021413-1ht1xm88 673 10 C C NNP cord-021413-1ht1xm88 673 11 , , , cord-021413-1ht1xm88 673 12 D D NNP cord-021413-1ht1xm88 673 13 , , , cord-021413-1ht1xm88 673 14 and and CC cord-021413-1ht1xm88 673 15 Ε Ε NNP cord-021413-1ht1xm88 673 16 to to TO cord-021413-1ht1xm88 673 17 genome genome NN cord-021413-1ht1xm88 673 18 segments segment NNS cord-021413-1ht1xm88 673 19 Plaque Plaque NNP cord-021413-1ht1xm88 673 20 formation formation NN cord-021413-1ht1xm88 673 21 by by IN cord-021413-1ht1xm88 673 22 reoviruses reoviruses NNP cord-021413-1ht1xm88 673 23 Cytochemical Cytochemical NNP cord-021413-1ht1xm88 673 24 , , , cord-021413-1ht1xm88 673 25 fluorescent fluorescent NN cord-021413-1ht1xm88 673 26 - - HYPH cord-021413-1ht1xm88 673 27 antibody antibody NN cord-021413-1ht1xm88 673 28 and and CC cord-021413-1ht1xm88 673 29 electron electron NN cord-021413-1ht1xm88 673 30 microscopic microscopic JJ cord-021413-1ht1xm88 673 31 studies study NNS cord-021413-1ht1xm88 673 32 on on IN cord-021413-1ht1xm88 673 33 the the DT cord-021413-1ht1xm88 673 34 growth growth NN cord-021413-1ht1xm88 673 35 of of IN cord-021413-1ht1xm88 673 36 reovirus reovirus NNP cord-021413-1ht1xm88 674 1 ( ( -LRB- cord-021413-1ht1xm88 674 2 ECHO ECHO NNP cord-021413-1ht1xm88 674 3 10 10 CD cord-021413-1ht1xm88 674 4 ) ) -RRB- cord-021413-1ht1xm88 674 5 in in IN cord-021413-1ht1xm88 674 6 tissue tissue NN cord-021413-1ht1xm88 674 7 culture culture NN cord-021413-1ht1xm88 674 8 Pathogenic pathogenic JJ cord-021413-1ht1xm88 674 9 murine murine JJ cord-021413-1ht1xm88 674 10 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 674 11 . . . cord-021413-1ht1xm88 675 1 I. I. NNP cord-021413-1ht1xm88 675 2 Characterization characterization NN cord-021413-1ht1xm88 675 3 of of IN cord-021413-1ht1xm88 675 4 biological biological JJ cord-021413-1ht1xm88 675 5 behavior behavior NN cord-021413-1ht1xm88 675 6 in in IN cord-021413-1ht1xm88 675 7 vitro vitro FW cord-021413-1ht1xm88 675 8 and and CC cord-021413-1ht1xm88 675 9 virus virus NN cord-021413-1ht1xm88 675 10 - - HYPH cord-021413-1ht1xm88 675 11 specific specific JJ cord-021413-1ht1xm88 675 12 in in IN cord-021413-1ht1xm88 675 13 tracellular tracellular NNP cord-021413-1ht1xm88 675 14 RNA RNA NNP cord-021413-1ht1xm88 675 15 of of IN cord-021413-1ht1xm88 675 16 strongly strongly RB cord-021413-1ht1xm88 675 17 neurotropic neurotropic NNP cord-021413-1ht1xm88 675 18 JHMV JHMV NNP cord-021413-1ht1xm88 675 19 and and CC cord-021413-1ht1xm88 675 20 weakly weakly RB cord-021413-1ht1xm88 675 21 neurotropic neurotropic NNP cord-021413-1ht1xm88 675 22 A59V A59V NNP cord-021413-1ht1xm88 675 23 viruses virus NNS cord-021413-1ht1xm88 675 24 Pathogenic pathogenic JJ cord-021413-1ht1xm88 675 25 murine murine JJ cord-021413-1ht1xm88 675 26 coronaviruses coronaviruse NNS cord-021413-1ht1xm88 675 27 . . . cord-021413-1ht1xm88 676 1 III III NNP cord-021413-1ht1xm88 676 2 . . . cord-021413-1ht1xm88 677 1 Biological biological JJ cord-021413-1ht1xm88 677 2 and and CC cord-021413-1ht1xm88 677 3 biochemical biochemical JJ cord-021413-1ht1xm88 677 4 characterization characterization NN cord-021413-1ht1xm88 677 5 of of IN cord-021413-1ht1xm88 677 6 temperature temperature NN cord-021413-1ht1xm88 677 7 - - HYPH cord-021413-1ht1xm88 677 8 sensitive sensitive JJ cord-021413-1ht1xm88 677 9 mutants mutant NNS cord-021413-1ht1xm88 677 10 of of IN cord-021413-1ht1xm88 677 11 JHMV JHMV NNP cord-021413-1ht1xm88 677 12 Demonstration Demonstration NNP cord-021413-1ht1xm88 677 13 of of IN cord-021413-1ht1xm88 677 14 reovirus reovirus NNP cord-021413-1ht1xm88 677 15 - - HYPH cord-021413-1ht1xm88 677 16 like like JJ cord-021413-1ht1xm88 677 17 particles particle NNS cord-021413-1ht1xm88 677 18 in in IN cord-021413-1ht1xm88 677 19 intestinal intestinal JJ cord-021413-1ht1xm88 677 20 contents content NNS cord-021413-1ht1xm88 677 21 of of IN cord-021413-1ht1xm88 677 22 piglets piglet NNS cord-021413-1ht1xm88 677 23 with with IN cord-021413-1ht1xm88 677 24 diarrhoea diarrhoea NN cord-021413-1ht1xm88 677 25 Comparison comparison NN cord-021413-1ht1xm88 677 26 of of IN cord-021413-1ht1xm88 677 27 the the DT cord-021413-1ht1xm88 677 28 genomes genome NNS cord-021413-1ht1xm88 677 29 of of IN cord-021413-1ht1xm88 677 30 simian simian JJ cord-021413-1ht1xm88 677 31 , , , cord-021413-1ht1xm88 677 32 bovine bovine JJ cord-021413-1ht1xm88 677 33 , , , cord-021413-1ht1xm88 677 34 and and CC cord-021413-1ht1xm88 677 35 human human JJ cord-021413-1ht1xm88 677 36 rotaviruses rotavirus NNS cord-021413-1ht1xm88 677 37 by by IN cord-021413-1ht1xm88 677 38 gel gel NN cord-021413-1ht1xm88 677 39 electrophoresis electrophoresis NN cord-021413-1ht1xm88 677 40 and and CC cord-021413-1ht1xm88 677 41 detec detec NN cord-021413-1ht1xm88 677 42 tion tion NN cord-021413-1ht1xm88 677 43 of of IN cord-021413-1ht1xm88 677 44 genomic genomic JJ cord-021413-1ht1xm88 677 45 variation variation NN cord-021413-1ht1xm88 677 46 among among IN cord-021413-1ht1xm88 677 47 bovine bovine JJ cord-021413-1ht1xm88 677 48 isolates isolate NNS cord-021413-1ht1xm88 677 49 Serologic Serologic NNP cord-021413-1ht1xm88 677 50 grouping grouping NN cord-021413-1ht1xm88 677 51 of of IN cord-021413-1ht1xm88 677 52 reoviruses reovirus NNS cord-021413-1ht1xm88 677 53 by by IN cord-021413-1ht1xm88 677 54 hemagglutinationinhibition hemagglutinationinhibition NNP cord-021413-1ht1xm88 677 55 Mouse Mouse NNP cord-021413-1ht1xm88 677 56 hepatitis hepatitis NN cord-021413-1ht1xm88 677 57 virus virus NN cord-021413-1ht1xm88 677 58 infection infection NN cord-021413-1ht1xm88 677 59 as as IN cord-021413-1ht1xm88 677 60 a a DT cord-021413-1ht1xm88 677 61 highly highly RB cord-021413-1ht1xm88 677 62 contagious contagious JJ cord-021413-1ht1xm88 677 63 , , , cord-021413-1ht1xm88 677 64 prevalent prevalent JJ cord-021413-1ht1xm88 677 65 , , , cord-021413-1ht1xm88 677 66 enteric enteric JJ cord-021413-1ht1xm88 677 67 infection infection NN cord-021413-1ht1xm88 677 68 of of IN cord-021413-1ht1xm88 677 69 mice mouse NNS cord-021413-1ht1xm88 678 1 Chloroform chloroform NN cord-021413-1ht1xm88 678 2 inactivation inactivation NN cord-021413-1ht1xm88 678 3 of of IN cord-021413-1ht1xm88 678 4 reovirus reovirus NNP cord-021413-1ht1xm88 678 5 hemagglutinins hemagglutinins NNP cord-021413-1ht1xm88 679 1 The the DT cord-021413-1ht1xm88 679 2 growth growth NN cord-021413-1ht1xm88 679 3 of of IN cord-021413-1ht1xm88 679 4 the the DT cord-021413-1ht1xm88 679 5 virus virus NN cord-021413-1ht1xm88 679 6 of of IN cord-021413-1ht1xm88 679 7 epidemic epidemic JJ cord-021413-1ht1xm88 679 8 diarrhea diarrhea NN cord-021413-1ht1xm88 679 9 of of IN cord-021413-1ht1xm88 679 10 infant infant NN cord-021413-1ht1xm88 679 11 mice mouse NNS cord-021413-1ht1xm88 679 12 ( ( -LRB- cord-021413-1ht1xm88 679 13 EDIM EDIM NNP cord-021413-1ht1xm88 679 14 ) ) -RRB- cord-021413-1ht1xm88 679 15 in in IN cord-021413-1ht1xm88 679 16 organ organ NN cord-021413-1ht1xm88 679 17 cultures culture NNS cord-021413-1ht1xm88 679 18 of of IN cord-021413-1ht1xm88 679 19 intestinal intestinal JJ cord-021413-1ht1xm88 679 20 epithelium epithelium NN cord-021413-1ht1xm88 679 21 Pathology Pathology NNP cord-021413-1ht1xm88 679 22 of of IN cord-021413-1ht1xm88 679 23 experimental experimental JJ cord-021413-1ht1xm88 679 24 hepatitis hepatitis NN cord-021413-1ht1xm88 679 25 in in IN cord-021413-1ht1xm88 679 26 mice mouse NNS cord-021413-1ht1xm88 680 1 The the DT cord-021413-1ht1xm88 680 2 Kupffer Kupffer NNP cord-021413-1ht1xm88 680 3 cell cell NN cord-021413-1ht1xm88 680 4 reaction reaction NN cord-021413-1ht1xm88 680 5 in in IN cord-021413-1ht1xm88 680 6 murine murine JJ cord-021413-1ht1xm88 680 7 and and CC cord-021413-1ht1xm88 680 8 human human JJ cord-021413-1ht1xm88 680 9 viral viral JJ cord-021413-1ht1xm88 680 10 hepatitis hepatitis NN cord-021413-1ht1xm88 680 11 with with IN cord-021413-1ht1xm88 680 12 particular particular JJ cord-021413-1ht1xm88 680 13 reference reference NN cord-021413-1ht1xm88 680 14 to to IN cord-021413-1ht1xm88 680 15 the the DT cord-021413-1ht1xm88 680 16 origin origin NN cord-021413-1ht1xm88 680 17 of of IN cord-021413-1ht1xm88 680 18 acidophilic acidophilic NNP cord-021413-1ht1xm88 680 19 bodies body NNS cord-021413-1ht1xm88 680 20 Electron Electron NNP cord-021413-1ht1xm88 680 21 microscopy microscopy NN cord-021413-1ht1xm88 680 22 of of IN cord-021413-1ht1xm88 680 23 the the DT cord-021413-1ht1xm88 680 24 hepatocellular hepatocellular NN cord-021413-1ht1xm88 680 25 and and CC cord-021413-1ht1xm88 680 26 Kupffer Kupffer NNP cord-021413-1ht1xm88 680 27 - - HYPH cord-021413-1ht1xm88 680 28 cell cell NN cord-021413-1ht1xm88 680 29 lesions lesion NNS cord-021413-1ht1xm88 680 30 of of IN cord-021413-1ht1xm88 680 31 mouse mouse NN cord-021413-1ht1xm88 680 32 hepatitis hepatitis NNP cord-021413-1ht1xm88 680 33 , , , cord-021413-1ht1xm88 680 34 with with IN cord-021413-1ht1xm88 680 35 par par FW cord-021413-1ht1xm88 680 36 ticular ticular JJ cord-021413-1ht1xm88 680 37 reference reference NN cord-021413-1ht1xm88 680 38 to to IN cord-021413-1ht1xm88 680 39 the the DT cord-021413-1ht1xm88 680 40 effect effect NN cord-021413-1ht1xm88 680 41 of of IN cord-021413-1ht1xm88 680 42 cortisone cortisone NN cord-021413-1ht1xm88 680 43 Factors factor NNS cord-021413-1ht1xm88 680 44 associated associate VBN cord-021413-1ht1xm88 680 45 with with IN cord-021413-1ht1xm88 680 46 the the DT cord-021413-1ht1xm88 680 47 incidence incidence NN cord-021413-1ht1xm88 680 48 of of IN cord-021413-1ht1xm88 680 49 infantile infantile JJ cord-021413-1ht1xm88 680 50 diarrhea diarrhea NN cord-021413-1ht1xm88 680 51 in in IN cord-021413-1ht1xm88 680 52 mice mice NN cord-021413-1ht1xm88 680 53 Reoviruses reovirus NNS cord-021413-1ht1xm88 680 54 . . . cord-021413-1ht1xm88 681 1 A a DT cord-021413-1ht1xm88 681 2 new new JJ cord-021413-1ht1xm88 681 3 group group NN cord-021413-1ht1xm88 681 4 of of IN cord-021413-1ht1xm88 681 5 respiratory respiratory JJ cord-021413-1ht1xm88 681 6 and and CC cord-021413-1ht1xm88 681 7 enteric enteric JJ cord-021413-1ht1xm88 681 8 viruses virus NNS cord-021413-1ht1xm88 681 9 formerly formerly RB cord-021413-1ht1xm88 681 10 classified classify VBN cord-021413-1ht1xm88 681 11 as as IN cord-021413-1ht1xm88 681 12 ECHO ECHO NNP cord-021413-1ht1xm88 681 13 type type NN cord-021413-1ht1xm88 681 14 10 10 CD cord-021413-1ht1xm88 681 15 is be VBZ cord-021413-1ht1xm88 681 16 described describe VBN cord-021413-1ht1xm88 681 17 Application Application NNP cord-021413-1ht1xm88 681 18 d'une d'une NNP cord-021413-1ht1xm88 681 19 technique technique NN cord-021413-1ht1xm88 681 20 immunoenzymologique immunoenzymologique NN cord-021413-1ht1xm88 681 21 ( ( -LRB- cord-021413-1ht1xm88 681 22 ELISA ELISA NNP cord-021413-1ht1xm88 681 23 ) ) -RRB- cord-021413-1ht1xm88 682 1 á á NN cord-021413-1ht1xm88 683 1 la la NNP cord-021413-1ht1xm88 683 2 detection detection NNP cord-021413-1ht1xm88 683 3 du du NNP cord-021413-1ht1xm88 683 4 rotavirus rotavirus JJ cord-021413-1ht1xm88 683 5 bovin bovin NNP cord-021413-1ht1xm88 683 6 et et NNP cord-021413-1ht1xm88 683 7 des des FW cord-021413-1ht1xm88 683 8 anticorps anticorps NNP cord-021413-1ht1xm88 683 9 diriges diriges NNP cord-021413-1ht1xm88 683 10 contre contre NNP cord-021413-1ht1xm88 683 11 lui lui NNP cord-021413-1ht1xm88 683 12 Enhancement Enhancement NNP cord-021413-1ht1xm88 683 13 of of IN cord-021413-1ht1xm88 683 14 antigen antigen NN cord-021413-1ht1xm88 683 15 incorporation incorporation NN cord-021413-1ht1xm88 683 16 and and CC cord-021413-1ht1xm88 683 17 infectivity infectivity NN cord-021413-1ht1xm88 683 18 of of IN cord-021413-1ht1xm88 683 19 cell cell NN cord-021413-1ht1xm88 683 20 cultures culture NNS cord-021413-1ht1xm88 683 21 by by IN cord-021413-1ht1xm88 683 22 human human JJ cord-021413-1ht1xm88 683 23 rotavirus rotavirus NN cord-021413-1ht1xm88 683 24 Rotavirus rotavirus NN cord-021413-1ht1xm88 683 25 in in IN cord-021413-1ht1xm88 683 26 goats goat NNS cord-021413-1ht1xm88 683 27 . . . cord-021413-1ht1xm88 684 1 Vet Vet NNP cord-021413-1ht1xm88 684 2 . . . cord-021413-1ht1xm88 685 1 Ree Ree NNP cord-021413-1ht1xm88 685 2 . . . cord-021413-1ht1xm88 686 1 103 103 CD cord-021413-1ht1xm88 686 2 Mouse Mouse NNP cord-021413-1ht1xm88 686 3 macrophages macrophage NNS cord-021413-1ht1xm88 686 4 as as IN cord-021413-1ht1xm88 686 5 host host NN cord-021413-1ht1xm88 686 6 cells cell NNS cord-021413-1ht1xm88 686 7 for for IN cord-021413-1ht1xm88 686 8 murine murine JJ cord-021413-1ht1xm88 686 9 viruses virus NNS cord-021413-1ht1xm88 687 1 Some some DT cord-021413-1ht1xm88 687 2 virus virus NN cord-021413-1ht1xm88 687 3 infections infection NNS cord-021413-1ht1xm88 687 4 of of IN cord-021413-1ht1xm88 687 5 mice mouse NNS cord-021413-1ht1xm88 687 6 Hepatitis hepatitis NN cord-021413-1ht1xm88 687 7 and and CC cord-021413-1ht1xm88 687 8 brain brain NN cord-021413-1ht1xm88 687 9 lesions lesion NNS cord-021413-1ht1xm88 687 10 due due JJ cord-021413-1ht1xm88 687 11 to to IN cord-021413-1ht1xm88 687 12 mouse mouse NNP cord-021413-1ht1xm88 687 13 hepatitis hepatitis NNP cord-021413-1ht1xm88 687 14 virus virus NN cord-021413-1ht1xm88 687 15 accompanied accompany VBN cord-021413-1ht1xm88 687 16 by by IN cord-021413-1ht1xm88 687 17 wasting waste VBG cord-021413-1ht1xm88 687 18 in in IN cord-021413-1ht1xm88 687 19 nude nude JJ cord-021413-1ht1xm88 687 20 mice mouse NNS cord-021413-1ht1xm88 688 1 A a DT cord-021413-1ht1xm88 688 2 genetic genetic JJ cord-021413-1ht1xm88 688 3 map map NN cord-021413-1ht1xm88 688 4 of of IN cord-021413-1ht1xm88 688 5 reovirus reovirus NNP cord-021413-1ht1xm88 688 6 . . . cord-021413-1ht1xm88 689 1 I. I. NNP cord-021413-1ht1xm88 689 2 Correlation correlation NN cord-021413-1ht1xm88 689 3 of of IN cord-021413-1ht1xm88 689 4 genome genome NN cord-021413-1ht1xm88 689 5 RNAs rna NNS cord-021413-1ht1xm88 689 6 between between IN cord-021413-1ht1xm88 689 7 serotypes serotypes NN cord-021413-1ht1xm88 689 8 1 1 CD cord-021413-1ht1xm88 689 9 , , , cord-021413-1ht1xm88 689 10 2 2 CD cord-021413-1ht1xm88 689 11 , , , cord-021413-1ht1xm88 689 12 and and CC cord-021413-1ht1xm88 689 13 3 3 CD cord-021413-1ht1xm88 689 14 Replication Replication NNP cord-021413-1ht1xm88 689 15 of of IN cord-021413-1ht1xm88 689 16 reovirus reovirus NNP cord-021413-1ht1xm88 689 17 Mouse Mouse NNP cord-021413-1ht1xm88 689 18 hepatitis hepatitis NN cord-021413-1ht1xm88 689 19 virus virus NN cord-021413-1ht1xm88 689 20 ( ( -LRB- cord-021413-1ht1xm88 689 21 MHV mhv NN cord-021413-1ht1xm88 689 22 ) ) -RRB- cord-021413-1ht1xm88 689 23 infection infection NN cord-021413-1ht1xm88 689 24 in in IN cord-021413-1ht1xm88 689 25 thymectomized thymectomize VBN cord-021413-1ht1xm88 689 26 C3H c3h JJ cord-021413-1ht1xm88 689 27 mice mouse NNS cord-021413-1ht1xm88 689 28 Rotavirus Rotavirus NNP cord-021413-1ht1xm88 689 29 infection infection NN cord-021413-1ht1xm88 689 30 of of IN cord-021413-1ht1xm88 689 31 neonatal neonatal JJ cord-021413-1ht1xm88 689 32 mice mouse NNS cord-021413-1ht1xm88 689 33 : : : cord-021413-1ht1xm88 689 34 characterization characterization NN cord-021413-1ht1xm88 689 35 of of IN cord-021413-1ht1xm88 689 36 the the DT cord-021413-1ht1xm88 689 37 humoral humoral JJ cord-021413-1ht1xm88 689 38 immune immune JJ cord-021413-1ht1xm88 689 39 response response NN cord-021413-1ht1xm88 689 40 Plaque Plaque NNP cord-021413-1ht1xm88 689 41 assay assay NN cord-021413-1ht1xm88 689 42 for for IN cord-021413-1ht1xm88 689 43 mouse mouse NNP cord-021413-1ht1xm88 689 44 hepatitis hepatitis NNP cord-021413-1ht1xm88 689 45 virus virus NN cord-021413-1ht1xm88 689 46 ( ( -LRB- cord-021413-1ht1xm88 689 47 MHV-2 mhv-2 NN cord-021413-1ht1xm88 689 48 ) ) -RRB- cord-021413-1ht1xm88 689 49 on on IN cord-021413-1ht1xm88 689 50 primary primary JJ cord-021413-1ht1xm88 689 51 macrophage macrophage NN cord-021413-1ht1xm88 689 52 cell cell NN cord-021413-1ht1xm88 689 53 cultures culture NNS cord-021413-1ht1xm88 690 1 In in IN cord-021413-1ht1xm88 690 2 vitro vitro FW cord-021413-1ht1xm88 690 3 interaction interaction NN cord-021413-1ht1xm88 690 4 of of IN cord-021413-1ht1xm88 690 5 mouse mouse NNP cord-021413-1ht1xm88 690 6 hepatitis hepatitis NNP cord-021413-1ht1xm88 690 7 virus virus NN cord-021413-1ht1xm88 690 8 and and CC cord-021413-1ht1xm88 690 9 macrophages macrophage NNS cord-021413-1ht1xm88 690 10 from from IN cord-021413-1ht1xm88 690 11 genetically genetically RB cord-021413-1ht1xm88 690 12 resistant resistant JJ cord-021413-1ht1xm88 690 13 mice mouse NNS cord-021413-1ht1xm88 690 14 . . . cord-021413-1ht1xm88 691 1 I. I. NNP cord-021413-1ht1xm88 691 2 Adsorption Adsorption NNP cord-021413-1ht1xm88 691 3 of of IN cord-021413-1ht1xm88 691 4 virus virus NN cord-021413-1ht1xm88 691 5 and and CC cord-021413-1ht1xm88 691 6 growth growth NN cord-021413-1ht1xm88 691 7 curves curve NNS cord-021413-1ht1xm88 692 1 Arboviruses Arboviruses NNP cord-021413-1ht1xm88 693 1 The the DT cord-021413-1ht1xm88 693 2 mechanisms mechanism NNS cord-021413-1ht1xm88 693 3 of of IN cord-021413-1ht1xm88 693 4 reoviris reoviris NNP cord-021413-1ht1xm88 693 5 uncoating uncoating NN cord-021413-1ht1xm88 693 6 and and CC cord-021413-1ht1xm88 693 7 gene gene NN cord-021413-1ht1xm88 693 8 activation activation NN cord-021413-1ht1xm88 693 9 in in IN cord-021413-1ht1xm88 693 10 vivo vivo NNP cord-021413-1ht1xm88 693 11 Anti anti JJ cord-021413-1ht1xm88 693 12 - - JJ cord-021413-1ht1xm88 693 13 rotavirus rotavirus JJ cord-021413-1ht1xm88 693 14 antibody antibody NN cord-021413-1ht1xm88 693 15 in in IN cord-021413-1ht1xm88 693 16 human human JJ cord-021413-1ht1xm88 693 17 colos colo NNS cord-021413-1ht1xm88 693 18 trum trum NNP cord-021413-1ht1xm88 693 19 The the DT cord-021413-1ht1xm88 693 20 Laboratory Laboratory NNP cord-021413-1ht1xm88 693 21 Mouse Mouse NNP cord-021413-1ht1xm88 693 22 . . . cord-021413-1ht1xm88 694 1 Selection Selection NNP cord-021413-1ht1xm88 694 2 and and CC cord-021413-1ht1xm88 694 3 Management Management NNP cord-021413-1ht1xm88 694 4 Rabbit Rabbit NNP cord-021413-1ht1xm88 694 5 cardiomyopathy cardiomyopathy NN cord-021413-1ht1xm88 694 6 , , , cord-021413-1ht1xm88 694 7 associated associate VBN cord-021413-1ht1xm88 694 8 with with IN cord-021413-1ht1xm88 694 9 a a DT cord-021413-1ht1xm88 694 10 virus virus NN cord-021413-1ht1xm88 694 11 antigenically antigenically RB cord-021413-1ht1xm88 694 12 related relate VBN cord-021413-1ht1xm88 694 13 to to IN cord-021413-1ht1xm88 694 14 human human JJ cord-021413-1ht1xm88 694 15 Coronavirus Coronavirus NNP cord-021413-1ht1xm88 694 16 strain strain NN cord-021413-1ht1xm88 694 17 229E 229e CD cord-021413-1ht1xm88 695 1 Gel gel NN cord-021413-1ht1xm88 695 2 electrophoresis electrophoresis NN cord-021413-1ht1xm88 695 3 of of IN cord-021413-1ht1xm88 695 4 rotavirus rotavirus JJ cord-021413-1ht1xm88 695 5 RNA RNA NNP cord-021413-1ht1xm88 695 6 derived derive VBN cord-021413-1ht1xm88 695 7 from from IN cord-021413-1ht1xm88 695 8 six six CD cord-021413-1ht1xm88 695 9 different different JJ cord-021413-1ht1xm88 695 10 animal animal NN cord-021413-1ht1xm88 695 11 species specie NNS cord-021413-1ht1xm88 695 12 Rotavirus Rotavirus NNP cord-021413-1ht1xm88 695 13 infection infection NN cord-021413-1ht1xm88 695 14 in in IN cord-021413-1ht1xm88 695 15 lambs lamb NNS cord-021413-1ht1xm88 695 16 : : : cord-021413-1ht1xm88 695 17 Studies study NNS cord-021413-1ht1xm88 695 18 on on IN cord-021413-1ht1xm88 695 19 passive passive JJ cord-021413-1ht1xm88 695 20 protection protection NN cord-021413-1ht1xm88 695 21 A a DT cord-021413-1ht1xm88 695 22 rotavirus rotavirus NN cord-021413-1ht1xm88 695 23 in in IN cord-021413-1ht1xm88 695 24 lambs lamb NNS cord-021413-1ht1xm88 695 25 with with IN cord-021413-1ht1xm88 695 26 diarrhoea diarrhoea NN cord-021413-1ht1xm88 695 27 Test Test NNP cord-021413-1ht1xm88 695 28 for for IN cord-021413-1ht1xm88 695 29 reovirus reovirus NNP cord-021413-1ht1xm88 695 30 - - HYPH cord-021413-1ht1xm88 695 31 like like JJ cord-021413-1ht1xm88 695 32 agent agent NN cord-021413-1ht1xm88 695 33 Enhancement Enhancement NNP cord-021413-1ht1xm88 695 34 of of IN cord-021413-1ht1xm88 695 35 reovirus reovirus JJ cord-021413-1ht1xm88 695 36 infectivity infectivity NN cord-021413-1ht1xm88 695 37 by by IN cord-021413-1ht1xm88 695 38 extracellular extracellular JJ cord-021413-1ht1xm88 695 39 removal removal NN cord-021413-1ht1xm88 695 40 or or CC cord-021413-1ht1xm88 695 41 alteration alteration NN cord-021413-1ht1xm88 695 42 of of IN cord-021413-1ht1xm88 695 43 the the DT cord-021413-1ht1xm88 695 44 virus virus NN cord-021413-1ht1xm88 695 45 capsid capsid NN cord-021413-1ht1xm88 695 46 by by IN cord-021413-1ht1xm88 695 47 proteolyitic proteolyitic JJ cord-021413-1ht1xm88 695 48 enzymes enzyme NNS cord-021413-1ht1xm88 695 49 Relationship Relationship NNP cord-021413-1ht1xm88 695 50 of of IN cord-021413-1ht1xm88 695 51 hepatoencephalomyelitis hepatoencephalomyelitis NN cord-021413-1ht1xm88 695 52 virus virus NN cord-021413-1ht1xm88 695 53 and and CC cord-021413-1ht1xm88 695 54 reoviruses reovirus NNS cord-021413-1ht1xm88 696 1 The the DT cord-021413-1ht1xm88 696 2 reovirus reovirus FW cord-021413-1ht1xm88 696 3 murine murine NN cord-021413-1ht1xm88 696 4 models model NNS cord-021413-1ht1xm88 696 5 Diagnosis Diagnosis NNP cord-021413-1ht1xm88 696 6 of of IN cord-021413-1ht1xm88 696 7 reovirus reovirus NNP cord-021413-1ht1xm88 696 8 infection infection NN cord-021413-1ht1xm88 696 9 : : : cord-021413-1ht1xm88 696 10 Comparative comparative JJ cord-021413-1ht1xm88 696 11 aspects aspect NNS cord-021413-1ht1xm88 696 12 Murine murine JJ cord-021413-1ht1xm88 696 13 infection infection NN cord-021413-1ht1xm88 696 14 with with IN cord-021413-1ht1xm88 696 15 reovirus reovirus NNP cord-021413-1ht1xm88 696 16 type type NNP cord-021413-1ht1xm88 696 17 3 3 CD cord-021413-1ht1xm88 696 18 and and CC cord-021413-1ht1xm88 696 19 the the DT cord-021413-1ht1xm88 696 20 runting runte VBG cord-021413-1ht1xm88 696 21 syndrome syndrome NN cord-021413-1ht1xm88 696 22 Studies Studies NNPS cord-021413-1ht1xm88 696 23 on on IN cord-021413-1ht1xm88 696 24 the the DT cord-021413-1ht1xm88 696 25 pathogenesis pathogenesis NN cord-021413-1ht1xm88 696 26 of of IN cord-021413-1ht1xm88 696 27 a a DT cord-021413-1ht1xm88 696 28 hitherto hitherto RB cord-021413-1ht1xm88 696 29 undescribed undescribed JJ cord-021413-1ht1xm88 696 30 virus virus NN cord-021413-1ht1xm88 696 31 ( ( -LRB- cord-021413-1ht1xm88 696 32 Hepatoencephalomyelitis Hepatoencephalomyelitis NNP cord-021413-1ht1xm88 696 33 ) ) -RRB- cord-021413-1ht1xm88 696 34 producing produce VBG cord-021413-1ht1xm88 696 35 unusual unusual JJ cord-021413-1ht1xm88 696 36 symptoms symptom NNS cord-021413-1ht1xm88 696 37 in in IN cord-021413-1ht1xm88 696 38 suckling suckle VBG cord-021413-1ht1xm88 696 39 mice mouse NNS cord-021413-1ht1xm88 696 40 Studies study NNS cord-021413-1ht1xm88 696 41 on on IN cord-021413-1ht1xm88 696 42 the the DT cord-021413-1ht1xm88 696 43 hepato hepato NN cord-021413-1ht1xm88 696 44 - - HYPH cord-021413-1ht1xm88 696 45 encephalomyelitis encephalomyelitis NN cord-021413-1ht1xm88 696 46 virus virus NN cord-021413-1ht1xm88 696 47 ( ( -LRB- cord-021413-1ht1xm88 696 48 HEV HEV NNP cord-021413-1ht1xm88 696 49 ) ) -RRB- cord-021413-1ht1xm88 696 50 Murine murine JJ cord-021413-1ht1xm88 696 51 infection infection NN cord-021413-1ht1xm88 696 52 with with IN cord-021413-1ht1xm88 696 53 reovirus reovirus NNP cord-021413-1ht1xm88 696 54 . . . cord-021413-1ht1xm88 697 1 II II NNP cord-021413-1ht1xm88 697 2 . . . cord-021413-1ht1xm88 698 1 The the DT cord-021413-1ht1xm88 698 2 chronic chronic JJ cord-021413-1ht1xm88 698 3 disease disease NN cord-021413-1ht1xm88 698 4 following follow VBG cord-021413-1ht1xm88 698 5 reovirus reovirus NNP cord-021413-1ht1xm88 698 6 type type NN cord-021413-1ht1xm88 698 7 3 3 CD cord-021413-1ht1xm88 698 8 infection infection NN cord-021413-1ht1xm88 698 9 Propagation propagation NN cord-021413-1ht1xm88 698 10 of of IN cord-021413-1ht1xm88 698 11 mouse mouse NN cord-021413-1ht1xm88 698 12 hepatitis hepatitis NN cord-021413-1ht1xm88 698 13 virus virus NN cord-021413-1ht1xm88 698 14 ( ( -LRB- cord-021413-1ht1xm88 698 15 Gledhill Gledhill NNP cord-021413-1ht1xm88 698 16 ) ) -RRB- cord-021413-1ht1xm88 698 17 in in IN cord-021413-1ht1xm88 698 18 tissue tissue NN cord-021413-1ht1xm88 698 19 culture culture NN cord-021413-1ht1xm88 698 20 Electron electron NN cord-021413-1ht1xm88 698 21 and and CC cord-021413-1ht1xm88 698 22 fluorescence fluorescence NN cord-021413-1ht1xm88 698 23 microscopy microscopy NNS cord-021413-1ht1xm88 698 24 of of IN cord-021413-1ht1xm88 698 25 mouse mouse NN cord-021413-1ht1xm88 698 26 hepatitis hepatitis NN cord-021413-1ht1xm88 698 27 virus virus NN cord-021413-1ht1xm88 698 28 Resistance resistance NN cord-021413-1ht1xm88 698 29 to to IN cord-021413-1ht1xm88 698 30 fatal fatal JJ cord-021413-1ht1xm88 698 31 central central JJ cord-021413-1ht1xm88 698 32 nervous nervous JJ cord-021413-1ht1xm88 698 33 system system NN cord-021413-1ht1xm88 698 34 disease disease NN cord-021413-1ht1xm88 698 35 by by IN cord-021413-1ht1xm88 698 36 mouse mouse NNP cord-021413-1ht1xm88 698 37 hepatitis hepatitis NNP cord-021413-1ht1xm88 698 38 virus virus NN cord-021413-1ht1xm88 698 39 , , , cord-021413-1ht1xm88 698 40 strain strain VB cord-021413-1ht1xm88 698 41 JHM JHM NNP cord-021413-1ht1xm88 698 42 . . . cord-021413-1ht1xm88 699 1 I. I. NNP cord-021413-1ht1xm88 699 2 Genetic genetic JJ cord-021413-1ht1xm88 699 3 analysis analysis NN cord-021413-1ht1xm88 699 4 Resistance resistance NN cord-021413-1ht1xm88 699 5 to to IN cord-021413-1ht1xm88 699 6 fatal fatal JJ cord-021413-1ht1xm88 699 7 central central JJ cord-021413-1ht1xm88 699 8 nervous nervous JJ cord-021413-1ht1xm88 699 9 system system NN cord-021413-1ht1xm88 699 10 disease disease NN cord-021413-1ht1xm88 699 11 by by IN cord-021413-1ht1xm88 699 12 mouse mouse NNP cord-021413-1ht1xm88 699 13 hepatitis hepatitis NNP cord-021413-1ht1xm88 699 14 virus virus NN cord-021413-1ht1xm88 699 15 , , , cord-021413-1ht1xm88 699 16 strain strain VB cord-021413-1ht1xm88 699 17 JHM JHM NNP cord-021413-1ht1xm88 699 18 . . . cord-021413-1ht1xm88 700 1 II II NNP cord-021413-1ht1xm88 700 2 . . . cord-021413-1ht1xm88 701 1 Adherent adherent JJ cord-021413-1ht1xm88 701 2 cell cell NN cord-021413-1ht1xm88 701 3 - - HYPH cord-021413-1ht1xm88 701 4 mediated mediate VBN cord-021413-1ht1xm88 701 5 protection protection NN cord-021413-1ht1xm88 701 6 Postsplenectomy Postsplenectomy NNP cord-021413-1ht1xm88 701 7 viral viral JJ cord-021413-1ht1xm88 701 8 hepatitis hepatitis NN cord-021413-1ht1xm88 701 9 Characterization characterization NN cord-021413-1ht1xm88 701 10 of of IN cord-021413-1ht1xm88 701 11 a a DT cord-021413-1ht1xm88 701 12 Coronavirus Coronavirus NNP cord-021413-1ht1xm88 701 13 . . . cord-021413-1ht1xm88 702 1 I. I. NNP cord-021413-1ht1xm88 702 2 Structural structural JJ cord-021413-1ht1xm88 702 3 pro pro JJ cord-021413-1ht1xm88 702 4 teins tein NNS cord-021413-1ht1xm88 702 5 : : : cord-021413-1ht1xm88 702 6 Effects effect NNS cord-021413-1ht1xm88 702 7 of of IN cord-021413-1ht1xm88 702 8 preparative preparative JJ cord-021413-1ht1xm88 702 9 conditions condition NNS cord-021413-1ht1xm88 702 10 on on IN cord-021413-1ht1xm88 702 11 the the DT cord-021413-1ht1xm88 702 12 migration migration NN cord-021413-1ht1xm88 702 13 of of IN cord-021413-1ht1xm88 702 14 protein protein NN cord-021413-1ht1xm88 702 15 in in IN cord-021413-1ht1xm88 702 16 Polyacrylamide Polyacrylamide NNP cord-021413-1ht1xm88 702 17 gels gel NNS cord-021413-1ht1xm88 703 1 An an DT cord-021413-1ht1xm88 703 2 electron electron NN cord-021413-1ht1xm88 703 3 microscopic microscopic JJ cord-021413-1ht1xm88 703 4 study study NN cord-021413-1ht1xm88 703 5 of of IN cord-021413-1ht1xm88 703 6 viral viral JJ cord-021413-1ht1xm88 703 7 hepatitis hepatitis NN cord-021413-1ht1xm88 703 8 in in IN cord-021413-1ht1xm88 703 9 mice mouse NNS cord-021413-1ht1xm88 703 10 Difference Difference NNP cord-021413-1ht1xm88 703 11 in in IN cord-021413-1ht1xm88 703 12 response response NN cord-021413-1ht1xm88 703 13 to to IN cord-021413-1ht1xm88 703 14 mouse mouse VB cord-021413-1ht1xm88 703 15 hepatitis hepatitis NN cord-021413-1ht1xm88 703 16 virus virus NN cord-021413-1ht1xm88 703 17 among among IN cord-021413-1ht1xm88 703 18 susceptible susceptible JJ cord-021413-1ht1xm88 703 19 mouse mouse NN cord-021413-1ht1xm88 703 20 strains strain NNS cord-021413-1ht1xm88 703 21 Factors factor NNS cord-021413-1ht1xm88 703 22 involved involve VBN cord-021413-1ht1xm88 703 23 in in IN cord-021413-1ht1xm88 703 24 the the DT cord-021413-1ht1xm88 703 25 age age NN cord-021413-1ht1xm88 703 26 - - HYPH cord-021413-1ht1xm88 703 27 dependent dependent JJ cord-021413-1ht1xm88 703 28 resistance resistance NN cord-021413-1ht1xm88 703 29 of of IN cord-021413-1ht1xm88 703 30 mice mouse NNS cord-021413-1ht1xm88 703 31 infected infect VBN cord-021413-1ht1xm88 703 32 with with IN cord-021413-1ht1xm88 703 33 low low JJ cord-021413-1ht1xm88 703 34 virulence virulence NN cord-021413-1ht1xm88 703 35 mouse mouse NN cord-021413-1ht1xm88 703 36 hepatitis hepatitis NN cord-021413-1ht1xm88 703 37 virus virus NN cord-021413-1ht1xm88 703 38 Pathogenesis Pathogenesis NNP cord-021413-1ht1xm88 703 39 of of IN cord-021413-1ht1xm88 703 40 mouse mouse NNP cord-021413-1ht1xm88 703 41 hepatitis hepatitis NN cord-021413-1ht1xm88 703 42 infection infection NN cord-021413-1ht1xm88 703 43 . . . cord-021413-1ht1xm88 704 1 The the DT cord-021413-1ht1xm88 704 2 role role NN cord-021413-1ht1xm88 704 3 of of IN cord-021413-1ht1xm88 704 4 nasal nasal JJ cord-021413-1ht1xm88 704 5 epithelial epithelial JJ cord-021413-1ht1xm88 704 6 cells cell NNS cord-021413-1ht1xm88 704 7 as as IN cord-021413-1ht1xm88 704 8 a a DT cord-021413-1ht1xm88 704 9 primary primary JJ cord-021413-1ht1xm88 704 10 target target NN cord-021413-1ht1xm88 704 11 of of IN cord-021413-1ht1xm88 704 12 low low JJ cord-021413-1ht1xm88 704 13 virulence virulence NN cord-021413-1ht1xm88 704 14 virus virus NN cord-021413-1ht1xm88 704 15 Asymptomatic asymptomatic JJ cord-021413-1ht1xm88 704 16 infection infection NN cord-021413-1ht1xm88 704 17 of of IN cord-021413-1ht1xm88 704 18 mouse mouse NN cord-021413-1ht1xm88 704 19 hepatitis hepatitis NNP cord-021413-1ht1xm88 704 20 virus virus NN cord-021413-1ht1xm88 704 21 in in IN cord-021413-1ht1xm88 704 22 the the DT cord-021413-1ht1xm88 704 23 rat rat NN cord-021413-1ht1xm88 705 1 In in IN cord-021413-1ht1xm88 705 2 vitro vitro FW cord-021413-1ht1xm88 705 3 growth growth NN cord-021413-1ht1xm88 705 4 characteristics characteristic NNS cord-021413-1ht1xm88 705 5 and and CC cord-021413-1ht1xm88 705 6 heterogeneity heterogeneity NN cord-021413-1ht1xm88 705 7 of of IN cord-021413-1ht1xm88 705 8 mouse mouse NN cord-021413-1ht1xm88 705 9 hepatitis hepatitis NNP cord-021413-1ht1xm88 705 10 virus virus NN cord-021413-1ht1xm88 705 11 type type NN cord-021413-1ht1xm88 705 12 3 3 CD cord-021413-1ht1xm88 705 13 IgM IgM NNP cord-021413-1ht1xm88 705 14 and and CC cord-021413-1ht1xm88 705 15 IgG IgG NNP cord-021413-1ht1xm88 705 16 response response NN cord-021413-1ht1xm88 705 17 to to IN cord-021413-1ht1xm88 705 18 sheep sheep NN cord-021413-1ht1xm88 705 19 red red JJ cord-021413-1ht1xm88 705 20 blood blood NN cord-021413-1ht1xm88 705 21 cells cell NNS cord-021413-1ht1xm88 705 22 in in IN cord-021413-1ht1xm88 705 23 mouse mouse NN cord-021413-1ht1xm88 705 24 hepatitis hepatitis NNP cord-021413-1ht1xm88 705 25 virus virus NN cord-021413-1ht1xm88 705 26 - - HYPH cord-021413-1ht1xm88 705 27 infected infect VBN cord-021413-1ht1xm88 705 28 nude nude JJ cord-021413-1ht1xm88 705 29 mice mouse NNS cord-021413-1ht1xm88 705 30 Response response NN cord-021413-1ht1xm88 705 31 of of IN cord-021413-1ht1xm88 705 32 nude nude JJ cord-021413-1ht1xm88 705 33 mice mouse NNS cord-021413-1ht1xm88 705 34 to to IN cord-021413-1ht1xm88 705 35 a a DT cord-021413-1ht1xm88 705 36 mouse mouse NN cord-021413-1ht1xm88 705 37 hepatitis hepatitis NN cord-021413-1ht1xm88 705 38 virus virus NN cord-021413-1ht1xm88 705 39 isolated isolate VBN cord-021413-1ht1xm88 705 40 from from IN cord-021413-1ht1xm88 705 41 a a DT cord-021413-1ht1xm88 705 42 wasting waste VBG cord-021413-1ht1xm88 705 43 nude nude JJ cord-021413-1ht1xm88 705 44 mouse mouse NN cord-021413-1ht1xm88 705 45 Persistent persistent JJ cord-021413-1ht1xm88 705 46 infection infection NN cord-021413-1ht1xm88 705 47 with with IN cord-021413-1ht1xm88 705 48 mouse mouse NN cord-021413-1ht1xm88 705 49 hepatitis hepatitis NN cord-021413-1ht1xm88 705 50 virus virus NN cord-021413-1ht1xm88 705 51 of of IN cord-021413-1ht1xm88 705 52 low low JJ cord-021413-1ht1xm88 705 53 virulence virulence NN cord-021413-1ht1xm88 705 54 in in IN cord-021413-1ht1xm88 705 55 nude nude JJ cord-021413-1ht1xm88 705 56 mice mouse NNS cord-021413-1ht1xm88 706 1 The the DT cord-021413-1ht1xm88 706 2 role role NN cord-021413-1ht1xm88 706 3 of of IN cord-021413-1ht1xm88 706 4 macrophages macrophage NNS cord-021413-1ht1xm88 706 5 in in IN cord-021413-1ht1xm88 706 6 the the DT cord-021413-1ht1xm88 706 7 early early JJ cord-021413-1ht1xm88 706 8 resistance resistance NN cord-021413-1ht1xm88 706 9 to to TO cord-021413-1ht1xm88 706 10 mouse mouse VB cord-021413-1ht1xm88 706 11 hepatitis hepatitis NNP cord-021413-1ht1xm88 706 12 virus virus NN cord-021413-1ht1xm88 706 13 infection infection NN cord-021413-1ht1xm88 706 14 in in IN cord-021413-1ht1xm88 706 15 nude nude JJ cord-021413-1ht1xm88 706 16 mice mouse NNS cord-021413-1ht1xm88 707 1 Enhanced enhanced JJ cord-021413-1ht1xm88 707 2 phagocytic phagocytic JJ cord-021413-1ht1xm88 707 3 activity activity NN cord-021413-1ht1xm88 707 4 of of IN cord-021413-1ht1xm88 707 5 macrophages macrophage NNS cord-021413-1ht1xm88 707 6 in in IN cord-021413-1ht1xm88 707 7 mouse mouse NN cord-021413-1ht1xm88 707 8 hepatitis hepatitis NNP cord-021413-1ht1xm88 707 9 virus virus NN cord-021413-1ht1xm88 707 10 - - HYPH cord-021413-1ht1xm88 707 11 infected infect VBN cord-021413-1ht1xm88 707 12 nude nude JJ cord-021413-1ht1xm88 707 13 mice mouse NNS cord-021413-1ht1xm88 707 14 Neonatal neonatal JJ cord-021413-1ht1xm88 707 15 susceptibility susceptibility NN cord-021413-1ht1xm88 707 16 to to IN cord-021413-1ht1xm88 707 17 MHV3 MHV3 NNP cord-021413-1ht1xm88 707 18 infection infection NN cord-021413-1ht1xm88 707 19 in in IN cord-021413-1ht1xm88 707 20 mice mouse NNS cord-021413-1ht1xm88 707 21 . . . cord-021413-1ht1xm88 708 1 II II NNP cord-021413-1ht1xm88 708 2 . . . cord-021413-1ht1xm88 709 1 Role role NN cord-021413-1ht1xm88 709 2 of of IN cord-021413-1ht1xm88 709 3 natural natural JJ cord-021413-1ht1xm88 709 4 effector effector NN cord-021413-1ht1xm88 709 5 marrow marrow NN cord-021413-1ht1xm88 709 6 cells cell NNS cord-021413-1ht1xm88 709 7 in in IN cord-021413-1ht1xm88 709 8 transfer transfer NN cord-021413-1ht1xm88 709 9 of of IN cord-021413-1ht1xm88 709 10 resistance resistance NN cord-021413-1ht1xm88 709 11 Techniques technique NNS cord-021413-1ht1xm88 709 12 for for IN cord-021413-1ht1xm88 709 13 rotaviral rotaviral JJ cord-021413-1ht1xm88 709 14 propagation propagation NN cord-021413-1ht1xm88 709 15 Rotavirus rotavirus NN cord-021413-1ht1xm88 709 16 neutralization neutralization NN cord-021413-1ht1xm88 709 17 by by IN cord-021413-1ht1xm88 709 18 human human JJ cord-021413-1ht1xm88 709 19 milk milk NN cord-021413-1ht1xm88 709 20 Serological serological JJ cord-021413-1ht1xm88 709 21 relation relation NN cord-021413-1ht1xm88 709 22 ships ship NNS cord-021413-1ht1xm88 709 23 between between IN cord-021413-1ht1xm88 709 24 rotaviruses rotavirus NNS cord-021413-1ht1xm88 709 25 from from IN cord-021413-1ht1xm88 709 26 different different JJ cord-021413-1ht1xm88 709 27 species specie NNS cord-021413-1ht1xm88 709 28 as as IN cord-021413-1ht1xm88 709 29 studied study VBN cord-021413-1ht1xm88 709 30 by by IN cord-021413-1ht1xm88 709 31 comple comple JJ cord-021413-1ht1xm88 709 32 ment ment NN cord-021413-1ht1xm88 709 33 fixation fixation NN cord-021413-1ht1xm88 709 34 and and CC cord-021413-1ht1xm88 709 35 neutralization neutralization NN cord-021413-1ht1xm88 709 36 Potentiating Potentiating NNP cord-021413-1ht1xm88 709 37 effect effect NN cord-021413-1ht1xm88 709 38 of of IN cord-021413-1ht1xm88 709 39 K k NN cord-021413-1ht1xm88 709 40 - - HYPH cord-021413-1ht1xm88 709 41 virus virus NN cord-021413-1ht1xm88 709 42 on on IN cord-021413-1ht1xm88 709 43 mouse mouse NN cord-021413-1ht1xm88 709 44 hepatitis hepatitis NNP cord-021413-1ht1xm88 709 45 virus virus NN cord-021413-1ht1xm88 709 46 ( ( -LRB- cord-021413-1ht1xm88 709 47 MHV MHV NNP cord-021413-1ht1xm88 709 48 - - HYPH cord-021413-1ht1xm88 709 49 S S NNP cord-021413-1ht1xm88 709 50 ) ) -RRB- cord-021413-1ht1xm88 709 51 in in IN cord-021413-1ht1xm88 709 52 weanling weanle VBG cord-021413-1ht1xm88 709 53 mice mouse NNS cord-021413-1ht1xm88 709 54 Runde Runde NNP cord-021413-1ht1xm88 709 55 " " '' cord-021413-1ht1xm88 709 56 virus virus NN cord-021413-1ht1xm88 709 57 , , , cord-021413-1ht1xm88 709 58 a a DT cord-021413-1ht1xm88 709 59 coronavirus coronavirus NN cord-021413-1ht1xm88 709 60 - - HYPH cord-021413-1ht1xm88 709 61 like like JJ cord-021413-1ht1xm88 709 62 agent agent NN cord-021413-1ht1xm88 709 63 associated associate VBN cord-021413-1ht1xm88 709 64 with with IN cord-021413-1ht1xm88 709 65 seabirds seabird NNS cord-021413-1ht1xm88 709 66 and and CC cord-021413-1ht1xm88 709 67 ticks tick VBZ cord-021413-1ht1xm88 709 68 Immunoelectroosmophoresis Immunoelectroosmophoresis NNP cord-021413-1ht1xm88 709 69 for for IN cord-021413-1ht1xm88 709 70 de de NNP cord-021413-1ht1xm88 709 71 tection tection NNP cord-021413-1ht1xm88 709 72 of of IN cord-021413-1ht1xm88 709 73 reo reo NNP cord-021413-1ht1xm88 709 74 - - HYPH cord-021413-1ht1xm88 709 75 like like JJ cord-021413-1ht1xm88 709 76 virus virus NN cord-021413-1ht1xm88 709 77 : : : cord-021413-1ht1xm88 709 78 Methodology methodology NN cord-021413-1ht1xm88 709 79 and and CC cord-021413-1ht1xm88 709 80 comparision comparision NN cord-021413-1ht1xm88 709 81 with with IN cord-021413-1ht1xm88 709 82 electron electron NN cord-021413-1ht1xm88 709 83 microscopy microscopy NN cord-021413-1ht1xm88 709 84 Inducers inducer NNS cord-021413-1ht1xm88 709 85 of of IN cord-021413-1ht1xm88 709 86 interferon interferon NN cord-021413-1ht1xm88 709 87 and and CC cord-021413-1ht1xm88 709 88 host host NN cord-021413-1ht1xm88 709 89 resistance resistance NN cord-021413-1ht1xm88 709 90 . . . cord-021413-1ht1xm88 710 1 III III NNP cord-021413-1ht1xm88 710 2 . . . cord-021413-1ht1xm88 711 1 Double double JJ cord-021413-1ht1xm88 711 2 - - HYPH cord-021413-1ht1xm88 711 3 stranded strand VBN cord-021413-1ht1xm88 711 4 RNA RNA NNP cord-021413-1ht1xm88 711 5 from from IN cord-021413-1ht1xm88 711 6 reovirus reovirus NNP cord-021413-1ht1xm88 711 7 type type NNP cord-021413-1ht1xm88 711 8 3 3 CD cord-021413-1ht1xm88 711 9 virions virion NNS cord-021413-1ht1xm88 711 10 ( ( -LRB- cord-021413-1ht1xm88 711 11 Reo Reo NNP cord-021413-1ht1xm88 711 12 3-RNA 3-RNA NNP cord-021413-1ht1xm88 711 13 ) ) -RRB- cord-021413-1ht1xm88 711 14 Isolation isolation NN cord-021413-1ht1xm88 711 15 of of IN cord-021413-1ht1xm88 711 16 rotavirus rotavirus NN cord-021413-1ht1xm88 711 17 from from IN cord-021413-1ht1xm88 711 18 deer deer NN cord-021413-1ht1xm88 711 19 Use use NN cord-021413-1ht1xm88 711 20 of of IN cord-021413-1ht1xm88 711 21 horseradish horseradish NN cord-021413-1ht1xm88 711 22 peroxidase peroxidase NN cord-021413-1ht1xm88 711 23 labelled label VBN cord-021413-1ht1xm88 711 24 antibody antibody NN cord-021413-1ht1xm88 711 25 for for IN cord-021413-1ht1xm88 711 26 light light NN cord-021413-1ht1xm88 711 27 and and CC cord-021413-1ht1xm88 711 28 electron electron NN cord-021413-1ht1xm88 711 29 microscopic microscopic JJ cord-021413-1ht1xm88 711 30 localiza localiza NN cord-021413-1ht1xm88 711 31 tion tion NN cord-021413-1ht1xm88 711 32 of of IN cord-021413-1ht1xm88 711 33 reovirus reovirus NNP cord-021413-1ht1xm88 711 34 antigen antigen NNP cord-021413-1ht1xm88 711 35 Studies Studies NNPS cord-021413-1ht1xm88 711 36 on on IN cord-021413-1ht1xm88 711 37 murine murine JJ cord-021413-1ht1xm88 711 38 hepatitis hepatitis NN cord-021413-1ht1xm88 711 39 virus virus NN cord-021413-1ht1xm88 711 40 ( ( -LRB- cord-021413-1ht1xm88 711 41 MHV3 MHV3 NNP cord-021413-1ht1xm88 711 42 ) ) -RRB- cord-021413-1ht1xm88 711 43 in in IN cord-021413-1ht1xm88 711 44 vitro vitro FW cord-021413-1ht1xm88 711 45 The the DT cord-021413-1ht1xm88 711 46 moφhology moφhology NN cord-021413-1ht1xm88 711 47 of of IN cord-021413-1ht1xm88 711 48 reovirus reovirus NNP cord-021413-1ht1xm88 711 49 New New NNP cord-021413-1ht1xm88 711 50 inteφretation inteφretation NN cord-021413-1ht1xm88 711 51 of of IN cord-021413-1ht1xm88 711 52 reovirus reovirus NNP cord-021413-1ht1xm88 711 53 struc struc NNP cord-021413-1ht1xm88 711 54 ture ture NNP cord-021413-1ht1xm88 711 55 Effect Effect NNP cord-021413-1ht1xm88 711 56 of of IN cord-021413-1ht1xm88 711 57 X x NN cord-021413-1ht1xm88 711 58 radiation radiation NN cord-021413-1ht1xm88 711 59 and and CC cord-021413-1ht1xm88 711 60 cortisone cortisone NN cord-021413-1ht1xm88 711 61 on on IN cord-021413-1ht1xm88 711 62 mouse mouse NN cord-021413-1ht1xm88 711 63 hepatitis hepatitis NNP cord-021413-1ht1xm88 711 64 virus virus NN cord-021413-1ht1xm88 711 65 infection infection NN cord-021413-1ht1xm88 711 66 in in IN cord-021413-1ht1xm88 711 67 germfree germfree NNP cord-021413-1ht1xm88 711 68 mice mouse NNS cord-021413-1ht1xm88 711 69 Correlation Correlation NNP cord-021413-1ht1xm88 711 70 of of IN cord-021413-1ht1xm88 711 71 persistent persistent JJ cord-021413-1ht1xm88 711 72 mouse mouse NN cord-021413-1ht1xm88 711 73 hepatitis hepatitis NN cord-021413-1ht1xm88 711 74 virus virus NN cord-021413-1ht1xm88 711 75 ( ( -LRB- cord-021413-1ht1xm88 711 76 MHV-3 MHV-3 NNP cord-021413-1ht1xm88 711 77 ) ) -RRB- cord-021413-1ht1xm88 711 78 infection infection NN cord-021413-1ht1xm88 711 79 with with IN cord-021413-1ht1xm88 711 80 its -PRON- PRP$ cord-021413-1ht1xm88 711 81 effect effect NN cord-021413-1ht1xm88 711 82 on on IN cord-021413-1ht1xm88 711 83 mouse mouse NN cord-021413-1ht1xm88 711 84 macrophage macrophage NN cord-021413-1ht1xm88 711 85 cultures culture NNS cord-021413-1ht1xm88 711 86 Role role NN cord-021413-1ht1xm88 711 87 of of IN cord-021413-1ht1xm88 711 88 interferon interferon NN cord-021413-1ht1xm88 711 89 in in IN cord-021413-1ht1xm88 711 90 the the DT cord-021413-1ht1xm88 711 91 pathogenesis pathogenesis NN cord-021413-1ht1xm88 711 92 of of IN cord-021413-1ht1xm88 711 93 viral viral JJ cord-021413-1ht1xm88 711 94 diseases disease NNS cord-021413-1ht1xm88 711 95 of of IN cord-021413-1ht1xm88 711 96 mice mouse NNS cord-021413-1ht1xm88 711 97 as as IN cord-021413-1ht1xm88 711 98 demonstrated demonstrate VBN cord-021413-1ht1xm88 711 99 by by IN cord-021413-1ht1xm88 711 100 the the DT cord-021413-1ht1xm88 711 101 use use NN cord-021413-1ht1xm88 711 102 of of IN cord-021413-1ht1xm88 711 103 anti anti JJ cord-021413-1ht1xm88 711 104 - - JJ cord-021413-1ht1xm88 711 105 interferon interferon JJ cord-021413-1ht1xm88 711 106 serum serum NN cord-021413-1ht1xm88 711 107 . . . cord-021413-1ht1xm88 712 1 V. V. NNP cord-021413-1ht1xm88 712 2 Protective protective JJ cord-021413-1ht1xm88 712 3 role role NN cord-021413-1ht1xm88 712 4 in in IN cord-021413-1ht1xm88 712 5 mouse mouse NN cord-021413-1ht1xm88 712 6 hepatitis hepatitis NNP cord-021413-1ht1xm88 712 7 virus virus NN cord-021413-1ht1xm88 712 8 type type NN cord-021413-1ht1xm88 712 9 3 3 CD cord-021413-1ht1xm88 712 10 infection infection NN cord-021413-1ht1xm88 712 11 of of IN cord-021413-1ht1xm88 712 12 susceptible susceptible JJ cord-021413-1ht1xm88 712 13 and and CC cord-021413-1ht1xm88 712 14 resistant resistant JJ cord-021413-1ht1xm88 712 15 strains strain NNS cord-021413-1ht1xm88 712 16 of of IN cord-021413-1ht1xm88 712 17 mice mouse NNS cord-021413-1ht1xm88 712 18 Neuropathological Neuropathological NNP cord-021413-1ht1xm88 712 19 effects effect NNS cord-021413-1ht1xm88 712 20 of of IN cord-021413-1ht1xm88 712 21 persistent persistent JJ cord-021413-1ht1xm88 712 22 infection infection NN cord-021413-1ht1xm88 712 23 of of IN cord-021413-1ht1xm88 712 24 mice mouse NNS cord-021413-1ht1xm88 712 25 by by IN cord-021413-1ht1xm88 712 26 mouse mouse NNP cord-021413-1ht1xm88 712 27 hepatitis hepatitis NNP cord-021413-1ht1xm88 712 28 virus virus NN cord-021413-1ht1xm88 713 1 The the DT cord-021413-1ht1xm88 713 2 role role NN cord-021413-1ht1xm88 713 3 of of IN cord-021413-1ht1xm88 713 4 circulating circulate VBG cord-021413-1ht1xm88 713 5 interferon interferon NN cord-021413-1ht1xm88 713 6 in in IN cord-021413-1ht1xm88 713 7 the the DT cord-021413-1ht1xm88 713 8 modifications modification NNS cord-021413-1ht1xm88 713 9 of of IN cord-021413-1ht1xm88 713 10 immune immune JJ cord-021413-1ht1xm88 713 11 responsiveness responsiveness NN cord-021413-1ht1xm88 713 12 by by IN cord-021413-1ht1xm88 713 13 mouse mouse NN cord-021413-1ht1xm88 713 14 hepatitis hepatitis NNP cord-021413-1ht1xm88 713 15 virus virus NN cord-021413-1ht1xm88 713 16 ( ( -LRB- cord-021413-1ht1xm88 713 17 MHV-3 MHV-3 NNP cord-021413-1ht1xm88 713 18 ) ) -RRB- cord-021413-1ht1xm88 714 1 Reovirus Reovirus NNP cord-021413-1ht1xm88 714 2 activation activation NN cord-021413-1ht1xm88 714 3 by by IN cord-021413-1ht1xm88 714 4 heating heating NN cord-021413-1ht1xm88 714 5 and and CC cord-021413-1ht1xm88 714 6 inactivation inactivation NN cord-021413-1ht1xm88 714 7 by by IN cord-021413-1ht1xm88 714 8 cooling cool VBG cord-021413-1ht1xm88 714 9 in in IN cord-021413-1ht1xm88 714 10 MgCl2 mgcl2 NN cord-021413-1ht1xm88 714 11 solutions solution NNS cord-021413-1ht1xm88 714 12 Effects effect NNS cord-021413-1ht1xm88 714 13 of of IN cord-021413-1ht1xm88 714 14 pancreatin pancreatin NNS cord-021413-1ht1xm88 714 15 on on IN cord-021413-1ht1xm88 714 16 the the DT cord-021413-1ht1xm88 714 17 growth growth NN cord-021413-1ht1xm88 714 18 of of IN cord-021413-1ht1xm88 714 19 reovirus reovirus NNP cord-021413-1ht1xm88 714 20 Murine Murine NNP cord-021413-1ht1xm88 714 21 infection infection NN cord-021413-1ht1xm88 714 22 with with IN cord-021413-1ht1xm88 714 23 reovirus reovirus NNP cord-021413-1ht1xm88 714 24 : : : cord-021413-1ht1xm88 715 1 I. I. NNP cord-021413-1ht1xm88 715 2 Pathology Pathology NNP cord-021413-1ht1xm88 715 3 of of IN cord-021413-1ht1xm88 715 4 the the DT cord-021413-1ht1xm88 715 5 acute acute JJ cord-021413-1ht1xm88 715 6 phase phase NN cord-021413-1ht1xm88 715 7 Naturally naturally RB cord-021413-1ht1xm88 715 8 occurring occur VBG cord-021413-1ht1xm88 715 9 mouse mouse NN cord-021413-1ht1xm88 715 10 hepatitis hepatitis NN cord-021413-1ht1xm88 715 11 virus virus NN cord-021413-1ht1xm88 715 12 infection infection NN cord-021413-1ht1xm88 715 13 in in IN cord-021413-1ht1xm88 715 14 the the DT cord-021413-1ht1xm88 715 15 nude nude JJ cord-021413-1ht1xm88 715 16 mouse mouse NN cord-021413-1ht1xm88 715 17 Identification Identification NNP cord-021413-1ht1xm88 715 18 of of IN cord-021413-1ht1xm88 715 19 detergents detergent NNS cord-021413-1ht1xm88 715 20 as as IN cord-021413-1ht1xm88 715 21 compo compo NN cord-021413-1ht1xm88 715 22 nents nent NNS cord-021413-1ht1xm88 715 23 of of IN cord-021413-1ht1xm88 715 24 wastewater wastewater NN cord-021413-1ht1xm88 715 25 sludge sludge NN cord-021413-1ht1xm88 715 26 that that WDT cord-021413-1ht1xm88 715 27 modify modify VBP cord-021413-1ht1xm88 715 28 the the DT cord-021413-1ht1xm88 715 29 thermal thermal JJ cord-021413-1ht1xm88 715 30 stability stability NN cord-021413-1ht1xm88 715 31 of of IN cord-021413-1ht1xm88 715 32 reovirus reovirus NNP cord-021413-1ht1xm88 715 33 and and CC cord-021413-1ht1xm88 715 34 enteroviruses enteroviruses NNP cord-021413-1ht1xm88 715 35 Effects effect NNS cord-021413-1ht1xm88 715 36 of of IN cord-021413-1ht1xm88 715 37 wastewater wastewater NN cord-021413-1ht1xm88 715 38 sludge sludge NN cord-021413-1ht1xm88 715 39 and and CC cord-021413-1ht1xm88 715 40 its -PRON- PRP$ cord-021413-1ht1xm88 715 41 detergents detergent NNS cord-021413-1ht1xm88 715 42 on on IN cord-021413-1ht1xm88 715 43 the the DT cord-021413-1ht1xm88 715 44 stability stability NN cord-021413-1ht1xm88 715 45 of of IN cord-021413-1ht1xm88 715 46 rotavirus rotavirus JJ cord-021413-1ht1xm88 715 47 Comparative Comparative NNP cord-021413-1ht1xm88 715 48 study study NN cord-021413-1ht1xm88 715 49 on on IN cord-021413-1ht1xm88 715 50 the the DT cord-021413-1ht1xm88 715 51 mechanisms mechanism NNS cord-021413-1ht1xm88 715 52 of of IN cord-021413-1ht1xm88 715 53 rotavirus rotavirus JJ cord-021413-1ht1xm88 715 54 inactivation inactivation NN cord-021413-1ht1xm88 715 55 by by IN cord-021413-1ht1xm88 715 56 sodium sodium NN cord-021413-1ht1xm88 715 57 dodecyl dodecyl NNP cord-021413-1ht1xm88 715 58 sulfate sulfate NN cord-021413-1ht1xm88 715 59 and and CC cord-021413-1ht1xm88 715 60 ethylenediaminetetracetate ethylenediaminetetracetate NNP cord-021413-1ht1xm88 715 61 Electron Electron NNP cord-021413-1ht1xm88 715 62 microscopic microscopic JJ cord-021413-1ht1xm88 715 63 studies study NNS cord-021413-1ht1xm88 715 64 of of IN cord-021413-1ht1xm88 715 65 experimental experimental JJ cord-021413-1ht1xm88 715 66 viral viral JJ cord-021413-1ht1xm88 715 67 hepatitis hepatitis NN cord-021413-1ht1xm88 715 68 in in IN cord-021413-1ht1xm88 715 69 mice mouse NNS cord-021413-1ht1xm88 715 70 . . . cord-021413-1ht1xm88 716 1 II II NNP cord-021413-1ht1xm88 716 2 . . . cord-021413-1ht1xm88 717 1 Ultrastructural ultrastructural JJ cord-021413-1ht1xm88 717 2 changes change NNS cord-021413-1ht1xm88 717 3 of of IN cord-021413-1ht1xm88 717 4 hepatocytes hepatocyte NNS cord-021413-1ht1xm88 717 5 associated associate VBN cord-021413-1ht1xm88 717 6 with with IN cord-021413-1ht1xm88 717 7 virus virus NN cord-021413-1ht1xm88 717 8 multiplication multiplication NN cord-021413-1ht1xm88 717 9 Electron Electron NNP cord-021413-1ht1xm88 717 10 microscopic microscopic JJ cord-021413-1ht1xm88 717 11 studies study NNS cord-021413-1ht1xm88 717 12 of of IN cord-021413-1ht1xm88 717 13 experimental experimental JJ cord-021413-1ht1xm88 717 14 viral viral JJ cord-021413-1ht1xm88 717 15 hepatitis hepatitis NN cord-021413-1ht1xm88 717 16 in in IN cord-021413-1ht1xm88 717 17 mice mouse NNS cord-021413-1ht1xm88 717 18 . . . cord-021413-1ht1xm88 718 1 I. I. NNP cord-021413-1ht1xm88 718 2 Virus virus NN cord-021413-1ht1xm88 718 3 particles particle NNS cord-021413-1ht1xm88 718 4 and and CC cord-021413-1ht1xm88 718 5 their -PRON- PRP$ cord-021413-1ht1xm88 718 6 relationship relationship NN cord-021413-1ht1xm88 718 7 to to IN cord-021413-1ht1xm88 718 8 hepatocytes hepatocyte NNS cord-021413-1ht1xm88 718 9 and and CC cord-021413-1ht1xm88 718 10 Kupffer Kupffer NNP cord-021413-1ht1xm88 718 11 cells cell NNS cord-021413-1ht1xm88 719 1 Structural structural JJ cord-021413-1ht1xm88 719 2 polypeptidesofthe polypeptidesofthe NN cord-021413-1ht1xm88 719 3 murinecoronavims murinecoronavim VBZ cord-021413-1ht1xm88 719 4 Neutralization neutralization NN cord-021413-1ht1xm88 719 5 of of IN cord-021413-1ht1xm88 719 6 reovirus reovirus NNP cord-021413-1ht1xm88 719 7 : : : cord-021413-1ht1xm88 720 1 the the DT cord-021413-1ht1xm88 720 2 gene gene NN cord-021413-1ht1xm88 720 3 responsible responsible JJ cord-021413-1ht1xm88 720 4 for for IN cord-021413-1ht1xm88 720 5 the the DT cord-021413-1ht1xm88 720 6 neutralization neutralization NN cord-021413-1ht1xm88 720 7 antigen antigen NN cord-021413-1ht1xm88 720 8 Molecular molecular JJ cord-021413-1ht1xm88 720 9 basis basis NN cord-021413-1ht1xm88 720 10 of of IN cord-021413-1ht1xm88 720 11 reovirus reovirus NNP cord-021413-1ht1xm88 720 12 virulence virulence NN cord-021413-1ht1xm88 720 13 : : : cord-021413-1ht1xm88 721 1 role role NN cord-021413-1ht1xm88 721 2 of of IN cord-021413-1ht1xm88 721 3 the the DT cord-021413-1ht1xm88 721 4 SI SI NNP cord-021413-1ht1xm88 721 5 gene gene NN cord-021413-1ht1xm88 721 6 Identification identification NN cord-021413-1ht1xm88 721 7 of of IN cord-021413-1ht1xm88 721 8 the the DT cord-021413-1ht1xm88 721 9 gene gene NN cord-021413-1ht1xm88 721 10 coding code VBG cord-021413-1ht1xm88 721 11 for for IN cord-021413-1ht1xm88 721 12 the the DT cord-021413-1ht1xm88 721 13 hemagglutinin hemagglutinin NN cord-021413-1ht1xm88 721 14 of of IN cord-021413-1ht1xm88 721 15 reovirus reovirus NNP cord-021413-1ht1xm88 721 16 Absolute Absolute NNP cord-021413-1ht1xm88 721 17 linkage linkage NN cord-021413-1ht1xm88 721 18 of of IN cord-021413-1ht1xm88 721 19 virulence virulence NN cord-021413-1ht1xm88 721 20 and and CC cord-021413-1ht1xm88 721 21 central central JJ cord-021413-1ht1xm88 721 22 nervous nervous JJ cord-021413-1ht1xm88 721 23 system system NN cord-021413-1ht1xm88 721 24 cell cell NN cord-021413-1ht1xm88 721 25 tropism tropism NN cord-021413-1ht1xm88 721 26 of of IN cord-021413-1ht1xm88 721 27 reoviruses reovirus NNS cord-021413-1ht1xm88 721 28 to to IN cord-021413-1ht1xm88 721 29 viral viral JJ cord-021413-1ht1xm88 721 30 hemagglutinin hemagglutinin NN cord-021413-1ht1xm88 721 31 Delayed delay VBN cord-021413-1ht1xm88 721 32 hypersen hypersen NN cord-021413-1ht1xm88 721 33 sitivity sitivity NN cord-021413-1ht1xm88 721 34 in in IN cord-021413-1ht1xm88 721 35 mice mouse NNS cord-021413-1ht1xm88 721 36 infected infect VBN cord-021413-1ht1xm88 721 37 with with IN cord-021413-1ht1xm88 721 38 reovirus reovirus NNP cord-021413-1ht1xm88 721 39 . . . cord-021413-1ht1xm88 722 1 I. I. NNP cord-021413-1ht1xm88 722 2 Identification Identification NNP cord-021413-1ht1xm88 722 3 of of IN cord-021413-1ht1xm88 722 4 host host NN cord-021413-1ht1xm88 722 5 and and CC cord-021413-1ht1xm88 722 6 viral viral JJ cord-021413-1ht1xm88 722 7 gene gene NN cord-021413-1ht1xm88 722 8 products product NNS cord-021413-1ht1xm88 722 9 responsible responsible JJ cord-021413-1ht1xm88 722 10 for for IN cord-021413-1ht1xm88 722 11 the the DT cord-021413-1ht1xm88 722 12 immune immune JJ cord-021413-1ht1xm88 722 13 response response NN cord-021413-1ht1xm88 722 14 Interaction Interaction NNP cord-021413-1ht1xm88 722 15 of of IN cord-021413-1ht1xm88 722 16 reovirus reovirus NNP cord-021413-1ht1xm88 722 17 with with IN cord-021413-1ht1xm88 722 18 cell cell NN cord-021413-1ht1xm88 722 19 surface surface NN cord-021413-1ht1xm88 722 20 receptors receptor NNS cord-021413-1ht1xm88 722 21 . . . cord-021413-1ht1xm88 723 1 I. I. NNP cord-021413-1ht1xm88 723 2 Murine Murine NNP cord-021413-1ht1xm88 723 3 and and CC cord-021413-1ht1xm88 723 4 human human JJ cord-021413-1ht1xm88 723 5 lymphocytes lymphocyte NNS cord-021413-1ht1xm88 723 6 have have VBP cord-021413-1ht1xm88 723 7 a a DT cord-021413-1ht1xm88 723 8 receptor receptor NN cord-021413-1ht1xm88 723 9 for for IN cord-021413-1ht1xm88 723 10 the the DT cord-021413-1ht1xm88 723 11 hemagglutinin hemagglutinin NN cord-021413-1ht1xm88 723 12 of of IN cord-021413-1ht1xm88 723 13 reovirus reovirus NNP cord-021413-1ht1xm88 723 14 type type NN cord-021413-1ht1xm88 723 15 3 3 CD cord-021413-1ht1xm88 723 16 Pathogenesis Pathogenesis NNP cord-021413-1ht1xm88 723 17 of of IN cord-021413-1ht1xm88 723 18 demyelination demyelination NN cord-021413-1ht1xm88 723 19 induced induce VBN cord-021413-1ht1xm88 723 20 by by IN cord-021413-1ht1xm88 723 21 a a DT cord-021413-1ht1xm88 723 22 mouse mouse NN cord-021413-1ht1xm88 723 23 hepatitis hepatitis NN cord-021413-1ht1xm88 723 24 vims vims NNP cord-021413-1ht1xm88 723 25 ( ( -LRB- cord-021413-1ht1xm88 723 26 JHM JHM NNP cord-021413-1ht1xm88 723 27 virus virus NN cord-021413-1ht1xm88 723 28 ) ) -RRB- cord-021413-1ht1xm88 724 1 Blocking block VBG cord-021413-1ht1xm88 724 2 of of IN cord-021413-1ht1xm88 724 3 in in IN cord-021413-1ht1xm88 724 4 vitro vitro FW cord-021413-1ht1xm88 724 5 and and CC cord-021413-1ht1xm88 724 6 in in IN cord-021413-1ht1xm88 724 7 vivo vivo NN cord-021413-1ht1xm88 724 8 susceptibility susceptibility NN cord-021413-1ht1xm88 724 9 to to TO cord-021413-1ht1xm88 724 10 mouse mouse VB cord-021413-1ht1xm88 724 11 hepatitis hepatitis NN cord-021413-1ht1xm88 724 12 vims vims NNP cord-021413-1ht1xm88 724 13 Importance importance NN cord-021413-1ht1xm88 724 14 of of IN cord-021413-1ht1xm88 724 15 local local JJ cord-021413-1ht1xm88 724 16 immunity immunity NN cord-021413-1ht1xm88 724 17 in in IN cord-021413-1ht1xm88 724 18 enteric enteric JJ cord-021413-1ht1xm88 724 19 infection infection NN cord-021413-1ht1xm88 724 20 Effect effect NN cord-021413-1ht1xm88 724 21 of of IN cord-021413-1ht1xm88 724 22 cy cy NNP cord-021413-1ht1xm88 724 23 clophosphamide clophosphamide NNP cord-021413-1ht1xm88 724 24 on on IN cord-021413-1ht1xm88 724 25 the the DT cord-021413-1ht1xm88 724 26 genetic genetic JJ cord-021413-1ht1xm88 724 27 resistance resistance NN cord-021413-1ht1xm88 724 28 of of IN cord-021413-1ht1xm88 724 29 C3H c3h JJ cord-021413-1ht1xm88 724 30 mice mouse NNS cord-021413-1ht1xm88 724 31 to to TO cord-021413-1ht1xm88 724 32 mouse mouse VB cord-021413-1ht1xm88 724 33 hepatitis hepatitis NNP cord-021413-1ht1xm88 724 34 vims vims NNP cord-021413-1ht1xm88 725 1 The the DT cord-021413-1ht1xm88 725 2 circadian circadian JJ cord-021413-1ht1xm88 725 3 rhythm rhythm NN cord-021413-1ht1xm88 725 4 of of IN cord-021413-1ht1xm88 725 5 thymosin thymosin NN cord-021413-1ht1xm88 725 6 therapy therapy NN cord-021413-1ht1xm88 725 7 during during IN cord-021413-1ht1xm88 725 8 acute acute JJ cord-021413-1ht1xm88 725 9 reovirus reovirus NNP cord-021413-1ht1xm88 725 10 type type NN cord-021413-1ht1xm88 725 11 3 3 CD cord-021413-1ht1xm88 725 12 infection infection NN cord-021413-1ht1xm88 725 13 of of IN cord-021413-1ht1xm88 725 14 neonatal neonatal JJ cord-021413-1ht1xm88 725 15 mice mouse NNS cord-021413-1ht1xm88 726 1 Immunofluorescent Immunofluorescent NNP cord-021413-1ht1xm88 726 2 detection detection NN cord-021413-1ht1xm88 726 3 of of IN cord-021413-1ht1xm88 726 4 murine murine JJ cord-021413-1ht1xm88 726 5 virus virus NN cord-021413-1ht1xm88 726 6 anti anti FW cord-021413-1ht1xm88 726 7 gens gens NNP cord-021413-1ht1xm88 726 8 Identification Identification NNP cord-021413-1ht1xm88 726 9 of of IN cord-021413-1ht1xm88 726 10 an an DT cord-021413-1ht1xm88 726 11 agent agent NN cord-021413-1ht1xm88 726 12 of of IN cord-021413-1ht1xm88 726 13 epizootic epizootic JJ cord-021413-1ht1xm88 726 14 diarrhea diarrhea NN cord-021413-1ht1xm88 726 15 of of IN cord-021413-1ht1xm88 726 16 infant infant NN cord-021413-1ht1xm88 726 17 mice mouse NNS cord-021413-1ht1xm88 726 18 by by IN cord-021413-1ht1xm88 726 19 immunofluorescent immunofluorescent NN cord-021413-1ht1xm88 726 20 and and CC cord-021413-1ht1xm88 726 21 complement complement NN cord-021413-1ht1xm88 726 22 - - HYPH cord-021413-1ht1xm88 726 23 fixation fixation NN cord-021413-1ht1xm88 726 24 tests test NNS cord-021413-1ht1xm88 727 1 Intestinal intestinal JJ cord-021413-1ht1xm88 727 2 Μ μ NN cord-021413-1ht1xm88 727 3 cells cell NNS cord-021413-1ht1xm88 727 4 : : : cord-021413-1ht1xm88 727 5 a a DT cord-021413-1ht1xm88 727 6 pathway pathway NN cord-021413-1ht1xm88 727 7 for for IN cord-021413-1ht1xm88 727 8 entry entry NN cord-021413-1ht1xm88 727 9 of of IN cord-021413-1ht1xm88 727 10 reovirus reovirus NNP cord-021413-1ht1xm88 727 11 into into IN cord-021413-1ht1xm88 727 12 the the DT cord-021413-1ht1xm88 727 13 host host NN cord-021413-1ht1xm88 727 14 Moφhological Moφhological NNP cord-021413-1ht1xm88 727 15 and and CC cord-021413-1ht1xm88 727 16 an an DT cord-021413-1ht1xm88 727 17 tigenic tigenic NN cord-021413-1ht1xm88 727 18 relationships relationship NNS cord-021413-1ht1xm88 727 19 between between IN cord-021413-1ht1xm88 727 20 viruses virus NNS cord-021413-1ht1xm88 727 21 ( ( -LRB- cord-021413-1ht1xm88 727 22 rotaviruses rotaviruses NNP cord-021413-1ht1xm88 727 23 ) ) -RRB- cord-021413-1ht1xm88 727 24 from from IN cord-021413-1ht1xm88 727 25 acute acute JJ cord-021413-1ht1xm88 727 26 gastroen gastroen JJ cord-021413-1ht1xm88 727 27 teritis teritis NN cord-021413-1ht1xm88 727 28 of of IN cord-021413-1ht1xm88 727 29 children child NNS cord-021413-1ht1xm88 727 30 , , , cord-021413-1ht1xm88 727 31 calves calf NNS cord-021413-1ht1xm88 727 32 , , , cord-021413-1ht1xm88 727 33 piglets piglet NNS cord-021413-1ht1xm88 727 34 , , , cord-021413-1ht1xm88 727 35 mice mouse NNS cord-021413-1ht1xm88 727 36 , , , cord-021413-1ht1xm88 727 37 and and CC cord-021413-1ht1xm88 727 38 foals foal NNS cord-021413-1ht1xm88 727 39 Intestinal intestinal JJ cord-021413-1ht1xm88 727 40 damage damage NN cord-021413-1ht1xm88 727 41 in in IN cord-021413-1ht1xm88 727 42 rotavirus rotavirus JJ cord-021413-1ht1xm88 727 43 infected infect VBN cord-021413-1ht1xm88 727 44 calves calf NNS cord-021413-1ht1xm88 727 45 assessed assess VBN cord-021413-1ht1xm88 727 46 by by IN cord-021413-1ht1xm88 727 47 D d NN cord-021413-1ht1xm88 727 48 - - HYPH cord-021413-1ht1xm88 727 49 xylose xylose NN cord-021413-1ht1xm88 727 50 malabsoφtion malabsoφtion NN cord-021413-1ht1xm88 727 51 Heat Heat NNP cord-021413-1ht1xm88 727 52 and and CC cord-021413-1ht1xm88 727 53 moisture moisture NN cord-021413-1ht1xm88 727 54 transfer transfer NN cord-021413-1ht1xm88 727 55 in in IN cord-021413-1ht1xm88 727 56 fllter fllter JJ cord-021413-1ht1xm88 727 57 - - HYPH cord-021413-1ht1xm88 727 58 top top JJ cord-021413-1ht1xm88 727 59 rodent rodent NN cord-021413-1ht1xm88 727 60 cages cage NNS cord-021413-1ht1xm88 727 61 Reovirus Reovirus NNP cord-021413-1ht1xm88 727 62 - - HYPH cord-021413-1ht1xm88 727 63 like like JJ cord-021413-1ht1xm88 727 64 agents agent NNS cord-021413-1ht1xm88 727 65 ( ( -LRB- cord-021413-1ht1xm88 727 66 Rotavimses Rotavimses NNPS cord-021413-1ht1xm88 727 67 ) ) -RRB- cord-021413-1ht1xm88 727 68 associated associate VBN cord-021413-1ht1xm88 727 69 with with IN cord-021413-1ht1xm88 727 70 diarrheal diarrheal JJ cord-021413-1ht1xm88 727 71 illness illness NN cord-021413-1ht1xm88 727 72 in in IN cord-021413-1ht1xm88 727 73 animals animal NNS cord-021413-1ht1xm88 727 74 and and CC cord-021413-1ht1xm88 727 75 man man NN cord-021413-1ht1xm88 727 76 Human human JJ cord-021413-1ht1xm88 727 77 rotavirus rotavirus NN cord-021413-1ht1xm88 727 78 type type NN cord-021413-1ht1xm88 727 79 2 2 CD cord-021413-1ht1xm88 727 80 : : : cord-021413-1ht1xm88 727 81 cultivation cultivation NN cord-021413-1ht1xm88 727 82 in in IN cord-021413-1ht1xm88 727 83 vitro vitro FW cord-021413-1ht1xm88 727 84 Enzyme enzyme NN cord-021413-1ht1xm88 727 85 - - HYPH cord-021413-1ht1xm88 727 86 linked link VBN cord-021413-1ht1xm88 727 87 fluorescence fluorescence NN cord-021413-1ht1xm88 727 88 assay assay NN cord-021413-1ht1xm88 727 89 : : : cord-021413-1ht1xm88 727 90 ultrasensitive ultrasensitive JJ cord-021413-1ht1xm88 727 91 solid solid JJ cord-021413-1ht1xm88 727 92 - - HYPH cord-021413-1ht1xm88 727 93 phase phase NN cord-021413-1ht1xm88 727 94 assay assay NN cord-021413-1ht1xm88 727 95 for for IN cord-021413-1ht1xm88 727 96 detection detection NN cord-021413-1ht1xm88 727 97 of of IN cord-021413-1ht1xm88 727 98 human human JJ cord-021413-1ht1xm88 727 99 rotavirus rotavirus NN cord-021413-1ht1xm88 727 100 Enzyme Enzyme NNP cord-021413-1ht1xm88 727 101 - - HYPH cord-021413-1ht1xm88 727 102 linked link VBN cord-021413-1ht1xm88 727 103 immunosorbent immunosorbent JJ cord-021413-1ht1xm88 727 104 assay assay NN cord-021413-1ht1xm88 727 105 for for IN cord-021413-1ht1xm88 727 106 identification identification NN cord-021413-1ht1xm88 727 107 of of IN cord-021413-1ht1xm88 727 108 rotaviruses rotavirus NNS cord-021413-1ht1xm88 727 109 from from IN cord-021413-1ht1xm88 727 110 different different JJ cord-021413-1ht1xm88 727 111 animal animal NN cord-021413-1ht1xm88 727 112 species species NN cord-021413-1ht1xm88 727 113 Measurement Measurement NNP cord-021413-1ht1xm88 727 114 of of IN cord-021413-1ht1xm88 727 115 rotavirus rotavirus JJ cord-021413-1ht1xm88 727 116 antibody antibody NN cord-021413-1ht1xm88 727 117 by by IN cord-021413-1ht1xm88 727 118 an an DT cord-021413-1ht1xm88 727 119 enzyme enzyme NN cord-021413-1ht1xm88 727 120 - - HYPH cord-021413-1ht1xm88 727 121 linked link VBN cord-021413-1ht1xm88 727 122 immunosorbent immunosorbent JJ cord-021413-1ht1xm88 727 123 assay assay NN cord-021413-1ht1xm88 727 124 blocking block VBG cord-021413-1ht1xm88 727 125 assay assay NN cord-021413-1ht1xm88 727 126 Secretory secretory JJ cord-021413-1ht1xm88 727 127 antibody antibody NN cord-021413-1ht1xm88 727 128 directed direct VBN cord-021413-1ht1xm88 727 129 against against IN cord-021413-1ht1xm88 727 130 rotavirus rotavirus NN cord-021413-1ht1xm88 727 131 in in IN cord-021413-1ht1xm88 727 132 human human JJ cord-021413-1ht1xm88 727 133 milk milk NN cord-021413-1ht1xm88 727 134 - - HYPH cord-021413-1ht1xm88 727 135 measurement measurement NN cord-021413-1ht1xm88 727 136 by by IN cord-021413-1ht1xm88 727 137 means mean NNS cord-021413-1ht1xm88 727 138 of of IN cord-021413-1ht1xm88 727 139 enzyme enzyme NN cord-021413-1ht1xm88 727 140 - - HYPH cord-021413-1ht1xm88 727 141 linked link VBN cord-021413-1ht1xm88 727 142 immunosorbent immunosorbent JJ cord-021413-1ht1xm88 727 143 assay assay NN