id sid tid token lemma pos cord-019051-gtruu1op 1 1 key key JJ cord-019051-gtruu1op 2 1 : : : cord-019051-gtruu1op 2 2 cord-019051-gtruu1op cord-019051-gtruu1op NFP cord-019051-gtruu1op 2 3 authors author NNS cord-019051-gtruu1op 2 4 : : : cord-019051-gtruu1op 2 5 Weber Weber NNP cord-019051-gtruu1op 2 6 , , , cord-019051-gtruu1op 2 7 Olaf Olaf NNP cord-019051-gtruu1op 2 8 title title NN cord-019051-gtruu1op 2 9 : : : cord-019051-gtruu1op 3 1 The the DT cord-019051-gtruu1op 3 2 role role NN cord-019051-gtruu1op 3 3 of of IN cord-019051-gtruu1op 3 4 viruses virus NNS cord-019051-gtruu1op 3 5 in in IN cord-019051-gtruu1op 3 6 the the DT cord-019051-gtruu1op 3 7 etiology etiology NN cord-019051-gtruu1op 3 8 and and CC cord-019051-gtruu1op 3 9 pathogenesis pathogenesis NN cord-019051-gtruu1op 3 10 of of IN cord-019051-gtruu1op 3 11 common common JJ cord-019051-gtruu1op 3 12 cold cold JJ cord-019051-gtruu1op 3 13 date date NN cord-019051-gtruu1op 3 14 : : : cord-019051-gtruu1op 3 15 2009 2009 CD cord-019051-gtruu1op 3 16 - - SYM cord-019051-gtruu1op 3 17 11 11 CD cord-019051-gtruu1op 3 18 - - SYM cord-019051-gtruu1op 3 19 10 10 CD cord-019051-gtruu1op 3 20 journal journal NN cord-019051-gtruu1op 3 21 : : : cord-019051-gtruu1op 4 1 Common common JJ cord-019051-gtruu1op 4 2 Cold Cold NNP cord-019051-gtruu1op 4 3 DOI doi NN cord-019051-gtruu1op 4 4 : : : cord-019051-gtruu1op 4 5 10.1007/978 10.1007/978 CD cord-019051-gtruu1op 4 6 - - HYPH cord-019051-gtruu1op 4 7 3 3 CD cord-019051-gtruu1op 4 8 - - HYPH cord-019051-gtruu1op 4 9 7643 7643 CD cord-019051-gtruu1op 4 10 - - HYPH cord-019051-gtruu1op 4 11 9912 9912 CD cord-019051-gtruu1op 4 12 - - SYM cord-019051-gtruu1op 4 13 2_5 2_5 CD cord-019051-gtruu1op 4 14 sha sha NNP cord-019051-gtruu1op 4 15 : : : cord-019051-gtruu1op 5 1 b3cb1753ce2e5f54121ae81b76132643bc9d39fc b3cb1753ce2e5f54121ae81b76132643bc9d39fc NNP cord-019051-gtruu1op 5 2 doc_id doc_id NNP cord-019051-gtruu1op 5 3 : : : cord-019051-gtruu1op 5 4 19051 19051 CD cord-019051-gtruu1op 5 5 cord_uid cord_uid NNS cord-019051-gtruu1op 5 6 : : : cord-019051-gtruu1op 6 1 gtruu1op gtruu1op NFP cord-019051-gtruu1op 6 2 Numerous numerous JJ cord-019051-gtruu1op 6 3 viruses virus NNS cord-019051-gtruu1op 6 4 are be VBP cord-019051-gtruu1op 6 5 able able JJ cord-019051-gtruu1op 6 6 to to TO cord-019051-gtruu1op 6 7 cause cause VB cord-019051-gtruu1op 6 8 respiratory respiratory JJ cord-019051-gtruu1op 6 9 tract tract NN cord-019051-gtruu1op 6 10 infections infection NNS cord-019051-gtruu1op 6 11 . . . cord-019051-gtruu1op 7 1 With with IN cord-019051-gtruu1op 7 2 the the DT cord-019051-gtruu1op 7 3 availability availability NN cord-019051-gtruu1op 7 4 of of IN cord-019051-gtruu1op 7 5 new new JJ cord-019051-gtruu1op 7 6 molecular molecular JJ cord-019051-gtruu1op 7 7 techniques technique NNS cord-019051-gtruu1op 7 8 , , , cord-019051-gtruu1op 7 9 the the DT cord-019051-gtruu1op 7 10 number number NN cord-019051-gtruu1op 7 11 of of IN cord-019051-gtruu1op 7 12 pathogens pathogen NNS cord-019051-gtruu1op 7 13 detected detect VBN cord-019051-gtruu1op 7 14 in in IN cord-019051-gtruu1op 7 15 specimens specimen NNS cord-019051-gtruu1op 7 16 from from IN cord-019051-gtruu1op 7 17 the the DT cord-019051-gtruu1op 7 18 human human JJ cord-019051-gtruu1op 7 19 respiratory respiratory JJ cord-019051-gtruu1op 7 20 tract tract NN cord-019051-gtruu1op 7 21 has have VBZ cord-019051-gtruu1op 7 22 increased increase VBN cord-019051-gtruu1op 7 23 . . . cord-019051-gtruu1op 8 1 Some some DT cord-019051-gtruu1op 8 2 of of IN cord-019051-gtruu1op 8 3 these these DT cord-019051-gtruu1op 8 4 viral viral JJ cord-019051-gtruu1op 8 5 infections infection NNS cord-019051-gtruu1op 8 6 have have VBP cord-019051-gtruu1op 8 7 the the DT cord-019051-gtruu1op 8 8 potential potential NN cord-019051-gtruu1op 8 9 to to TO cord-019051-gtruu1op 8 10 lead lead VB cord-019051-gtruu1op 8 11 to to IN cord-019051-gtruu1op 8 12 severe severe JJ cord-019051-gtruu1op 8 13 systemic systemic JJ cord-019051-gtruu1op 8 14 disease disease NN cord-019051-gtruu1op 8 15 . . . cord-019051-gtruu1op 9 1 Other other JJ cord-019051-gtruu1op 9 2 viruses virus NNS cord-019051-gtruu1op 9 3 are be VBP cord-019051-gtruu1op 9 4 limited limit VBN cord-019051-gtruu1op 9 5 to to IN cord-019051-gtruu1op 9 6 playing play VBG cord-019051-gtruu1op 9 7 a a DT cord-019051-gtruu1op 9 8 role role NN cord-019051-gtruu1op 9 9 in in IN cord-019051-gtruu1op 9 10 the the DT cord-019051-gtruu1op 9 11 pathogenesis pathogenesis NN cord-019051-gtruu1op 9 12 of of IN cord-019051-gtruu1op 9 13 the the DT cord-019051-gtruu1op 9 14 common common JJ cord-019051-gtruu1op 9 15 cold cold JJ cord-019051-gtruu1op 9 16 syndrome syndrome NN cord-019051-gtruu1op 9 17 . . . cord-019051-gtruu1op 10 1 This this DT cord-019051-gtruu1op 10 2 chapter chapter NN cord-019051-gtruu1op 10 3 focuses focus VBZ cord-019051-gtruu1op 10 4 on on IN cord-019051-gtruu1op 10 5 the the DT cord-019051-gtruu1op 10 6 viral viral JJ cord-019051-gtruu1op 10 7 pathogens pathogen NNS cord-019051-gtruu1op 10 8 that that WDT cord-019051-gtruu1op 10 9 are be VBP cord-019051-gtruu1op 10 10 linked link VBN cord-019051-gtruu1op 10 11 to to IN cord-019051-gtruu1op 10 12 common common JJ cord-019051-gtruu1op 10 13 cold cold NN cord-019051-gtruu1op 10 14 . . . cord-019051-gtruu1op 11 1 It -PRON- PRP cord-019051-gtruu1op 11 2 is be VBZ cord-019051-gtruu1op 11 3 not not RB cord-019051-gtruu1op 11 4 the the DT cord-019051-gtruu1op 11 5 intention intention NN cord-019051-gtruu1op 11 6 to to TO cord-019051-gtruu1op 11 7 comprehensively comprehensively RB cord-019051-gtruu1op 11 8 review review VB cord-019051-gtruu1op 11 9 all all PDT cord-019051-gtruu1op 11 10 the the DT cord-019051-gtruu1op 11 11 viruses virus NNS cord-019051-gtruu1op 11 12 that that WDT cord-019051-gtruu1op 11 13 are be VBP cord-019051-gtruu1op 11 14 able able JJ cord-019051-gtruu1op 11 15 to to TO cord-019051-gtruu1op 11 16 cause cause VB cord-019051-gtruu1op 11 17 respiratory respiratory JJ cord-019051-gtruu1op 11 18 tract tract NN cord-019051-gtruu1op 11 19 infections infection NNS cord-019051-gtruu1op 11 20 — — : cord-019051-gtruu1op 11 21 this this DT cord-019051-gtruu1op 11 22 would would MD cord-019051-gtruu1op 11 23 go go VB cord-019051-gtruu1op 11 24 beyond beyond IN cord-019051-gtruu1op 11 25 the the DT cord-019051-gtruu1op 11 26 scope scope NN cord-019051-gtruu1op 11 27 of of IN cord-019051-gtruu1op 11 28 this this DT cord-019051-gtruu1op 11 29 book book NN cord-019051-gtruu1op 11 30 . . . cord-019051-gtruu1op 12 1 The the DT cord-019051-gtruu1op 12 2 list list NN cord-019051-gtruu1op 12 3 of of IN cord-019051-gtruu1op 12 4 viruses virus NNS cord-019051-gtruu1op 12 5 that that WDT cord-019051-gtruu1op 12 6 are be VBP cord-019051-gtruu1op 12 7 briefly briefly RB cord-019051-gtruu1op 12 8 reviewed review VBN cord-019051-gtruu1op 12 9 here here RB cord-019051-gtruu1op 12 10 includes include VBZ cord-019051-gtruu1op 12 11 rhinoviruses rhinovirus NNS cord-019051-gtruu1op 12 12 , , , cord-019051-gtruu1op 12 13 respiratory respiratory JJ cord-019051-gtruu1op 12 14 syncytial syncytial JJ cord-019051-gtruu1op 12 15 virus virus NN cord-019051-gtruu1op 12 16 , , , cord-019051-gtruu1op 12 17 parainfluenza parainfluenza NNP cord-019051-gtruu1op 12 18 virus virus NNP cord-019051-gtruu1op 12 19 , , , cord-019051-gtruu1op 12 20 adenovirus adenovirus NN cord-019051-gtruu1op 12 21 , , , cord-019051-gtruu1op 12 22 metapneumovirus metapneumovirus NN cord-019051-gtruu1op 12 23 and and CC cord-019051-gtruu1op 12 24 coronavirus coronavirus NN cord-019051-gtruu1op 12 25 . . . cord-019051-gtruu1op 13 1 Bocavirus Bocavirus NNP cord-019051-gtruu1op 13 2 is be VBZ cord-019051-gtruu1op 13 3 discussed discuss VBN cord-019051-gtruu1op 13 4 as as IN cord-019051-gtruu1op 13 5 one one CD cord-019051-gtruu1op 13 6 example example NN cord-019051-gtruu1op 13 7 of of IN cord-019051-gtruu1op 13 8 a a DT cord-019051-gtruu1op 13 9 newly newly RB cord-019051-gtruu1op 13 10 identified identify VBN cord-019051-gtruu1op 13 11 pathogen pathogen NN cord-019051-gtruu1op 13 12 with with IN cord-019051-gtruu1op 13 13 a a DT cord-019051-gtruu1op 13 14 less less RBR cord-019051-gtruu1op 13 15 established established JJ cord-019051-gtruu1op 13 16 role role NN cord-019051-gtruu1op 13 17 in in IN cord-019051-gtruu1op 13 18 the the DT cord-019051-gtruu1op 13 19 etiology etiology NN cord-019051-gtruu1op 13 20 and and CC cord-019051-gtruu1op 13 21 pathogenesis pathogenesis NN cord-019051-gtruu1op 13 22 of of IN cord-019051-gtruu1op 13 23 common common JJ cord-019051-gtruu1op 13 24 cold cold NN cord-019051-gtruu1op 13 25 . . . cord-019051-gtruu1op 14 1 Influenza influenza NN cord-019051-gtruu1op 14 2 virus virus NN cord-019051-gtruu1op 14 3 does do VBZ cord-019051-gtruu1op 14 4 not not RB cord-019051-gtruu1op 14 5 cause cause VB cord-019051-gtruu1op 14 6 what what WP cord-019051-gtruu1op 14 7 is be VBZ cord-019051-gtruu1op 14 8 defined define VBN cord-019051-gtruu1op 14 9 as as IN cord-019051-gtruu1op 14 10 common common JJ cord-019051-gtruu1op 14 11 cold cold NN cord-019051-gtruu1op 14 12 . . . cord-019051-gtruu1op 15 1 However however RB cord-019051-gtruu1op 15 2 , , , cord-019051-gtruu1op 15 3 influenza influenza NN cord-019051-gtruu1op 15 4 viruses virus NNS cord-019051-gtruu1op 15 5 are be VBP cord-019051-gtruu1op 15 6 associated associate VBN cord-019051-gtruu1op 15 7 with with IN cord-019051-gtruu1op 15 8 respiratory respiratory JJ cord-019051-gtruu1op 15 9 disease disease NN cord-019051-gtruu1op 15 10 and and CC cord-019051-gtruu1op 15 11 the the DT cord-019051-gtruu1op 15 12 clinical clinical JJ cord-019051-gtruu1op 15 13 picture picture NN cord-019051-gtruu1op 15 14 of of IN cord-019051-gtruu1op 15 15 mild mild JJ cord-019051-gtruu1op 15 16 influenza influenza NN cord-019051-gtruu1op 15 17 and and CC cord-019051-gtruu1op 15 18 common common JJ cord-019051-gtruu1op 15 19 cold cold NN cord-019051-gtruu1op 15 20 frequently frequently RB cord-019051-gtruu1op 15 21 overlaps overlap VBZ cord-019051-gtruu1op 15 22 . . . cord-019051-gtruu1op 16 1 Therefore therefore RB cord-019051-gtruu1op 16 2 , , , cord-019051-gtruu1op 16 3 influenza influenza NN cord-019051-gtruu1op 16 4 virus virus NN cord-019051-gtruu1op 16 5 has have VBZ cord-019051-gtruu1op 16 6 been be VBN cord-019051-gtruu1op 16 7 included include VBN cord-019051-gtruu1op 16 8 in in IN cord-019051-gtruu1op 16 9 this this DT cord-019051-gtruu1op 16 10 chapter chapter NN cord-019051-gtruu1op 16 11 . . . cord-019051-gtruu1op 17 1 It -PRON- PRP cord-019051-gtruu1op 17 2 is be VBZ cord-019051-gtruu1op 17 3 important important JJ cord-019051-gtruu1op 17 4 to to TO cord-019051-gtruu1op 17 5 note note VB cord-019051-gtruu1op 17 6 that that IN cord-019051-gtruu1op 17 7 a a DT cord-019051-gtruu1op 17 8 number number NN cord-019051-gtruu1op 17 9 of of IN cord-019051-gtruu1op 17 10 viruses virus NNS cord-019051-gtruu1op 17 11 are be VBP cord-019051-gtruu1op 17 12 frequently frequently RB cord-019051-gtruu1op 17 13 co co VBN cord-019051-gtruu1op 17 14 - - VBN cord-019051-gtruu1op 17 15 detected detect VBN cord-019051-gtruu1op 17 16 with with IN cord-019051-gtruu1op 17 17 other other JJ cord-019051-gtruu1op 17 18 viruses virus NNS cord-019051-gtruu1op 17 19 in in IN cord-019051-gtruu1op 17 20 humans human NNS cord-019051-gtruu1op 17 21 with with IN cord-019051-gtruu1op 17 22 respiratory respiratory JJ cord-019051-gtruu1op 17 23 diseases disease NNS cord-019051-gtruu1op 17 24 . . . cord-019051-gtruu1op 18 1 Therefore therefore RB cord-019051-gtruu1op 18 2 , , , cord-019051-gtruu1op 18 3 the the DT cord-019051-gtruu1op 18 4 viral viral JJ cord-019051-gtruu1op 18 5 etiology etiology NN cord-019051-gtruu1op 18 6 and and CC cord-019051-gtruu1op 18 7 the the DT cord-019051-gtruu1op 18 8 role role NN cord-019051-gtruu1op 18 9 of of IN cord-019051-gtruu1op 18 10 viruses virus NNS cord-019051-gtruu1op 18 11 in in IN cord-019051-gtruu1op 18 12 the the DT cord-019051-gtruu1op 18 13 pathogenesis pathogenesis NN cord-019051-gtruu1op 18 14 of of IN cord-019051-gtruu1op 18 15 common common JJ cord-019051-gtruu1op 18 16 cold cold NN cord-019051-gtruu1op 18 17 is be VBZ cord-019051-gtruu1op 18 18 complex complex JJ cord-019051-gtruu1op 18 19 , , , cord-019051-gtruu1op 18 20 and and CC cord-019051-gtruu1op 18 21 numberous numberous JJ cord-019051-gtruu1op 18 22 questions question NNS cord-019051-gtruu1op 18 23 remain remain VBP cord-019051-gtruu1op 18 24 to to TO cord-019051-gtruu1op 18 25 be be VB cord-019051-gtruu1op 18 26 answered answer VBN cord-019051-gtruu1op 18 27 . . . cord-019051-gtruu1op 19 1 Numerous numerous JJ cord-019051-gtruu1op 19 2 viruses virus NNS cord-019051-gtruu1op 19 3 are be VBP cord-019051-gtruu1op 19 4 able able JJ cord-019051-gtruu1op 19 5 to to TO cord-019051-gtruu1op 19 6 cause cause VB cord-019051-gtruu1op 19 7 respiratory respiratory JJ cord-019051-gtruu1op 19 8 tract tract NN cord-019051-gtruu1op 19 9 infections infection NNS cord-019051-gtruu1op 19 10 . . . cord-019051-gtruu1op 20 1 Some some DT cord-019051-gtruu1op 20 2 of of IN cord-019051-gtruu1op 20 3 these these DT cord-019051-gtruu1op 20 4 may may MD cord-019051-gtruu1op 20 5 also also RB cord-019051-gtruu1op 20 6 cause cause VB cord-019051-gtruu1op 20 7 severe severe JJ cord-019051-gtruu1op 20 8 diseases disease NNS cord-019051-gtruu1op 20 9 . . . cord-019051-gtruu1op 21 1 Others other NNS cord-019051-gtruu1op 21 2 are be VBP cord-019051-gtruu1op 21 3 limited limit VBN cord-019051-gtruu1op 21 4 to to IN cord-019051-gtruu1op 21 5 a a DT cord-019051-gtruu1op 21 6 role role NN cord-019051-gtruu1op 21 7 in in IN cord-019051-gtruu1op 21 8 the the DT cord-019051-gtruu1op 21 9 pathogenesis pathogenesis NN cord-019051-gtruu1op 21 10 of of IN cord-019051-gtruu1op 21 11 the the DT cord-019051-gtruu1op 21 12 common common JJ cord-019051-gtruu1op 21 13 cold cold JJ cord-019051-gtruu1op 21 14 syndrome syndrome NN cord-019051-gtruu1op 21 15 . . . cord-019051-gtruu1op 22 1 With with IN cord-019051-gtruu1op 22 2 the the DT cord-019051-gtruu1op 22 3 availability availability NN cord-019051-gtruu1op 22 4 of of IN cord-019051-gtruu1op 22 5 new new JJ cord-019051-gtruu1op 22 6 molecular molecular JJ cord-019051-gtruu1op 22 7 techniques technique NNS cord-019051-gtruu1op 22 8 , , , cord-019051-gtruu1op 22 9 the the DT cord-019051-gtruu1op 22 10 number number NN cord-019051-gtruu1op 22 11 of of IN cord-019051-gtruu1op 22 12 pathogens pathogen NNS cord-019051-gtruu1op 22 13 detected detect VBN cord-019051-gtruu1op 22 14 in in IN cord-019051-gtruu1op 22 15 specimens specimen NNS cord-019051-gtruu1op 22 16 from from IN cord-019051-gtruu1op 22 17 the the DT cord-019051-gtruu1op 22 18 human human JJ cord-019051-gtruu1op 22 19 respiratory respiratory JJ cord-019051-gtruu1op 22 20 tract tract NN cord-019051-gtruu1op 22 21 has have VBZ cord-019051-gtruu1op 22 22 increased increase VBN cord-019051-gtruu1op 22 23 . . . cord-019051-gtruu1op 23 1 The the DT cord-019051-gtruu1op 23 2 association association NN cord-019051-gtruu1op 23 3 of of IN cord-019051-gtruu1op 23 4 some some DT cord-019051-gtruu1op 23 5 of of IN cord-019051-gtruu1op 23 6 these these DT cord-019051-gtruu1op 23 7 agents agent NNS cord-019051-gtruu1op 23 8 with with IN cord-019051-gtruu1op 23 9 human human JJ cord-019051-gtruu1op 23 10 respiratory respiratory JJ cord-019051-gtruu1op 23 11 disease disease NN cord-019051-gtruu1op 23 12 is be VBZ cord-019051-gtruu1op 23 13 not not RB cord-019051-gtruu1op 23 14 always always RB cord-019051-gtruu1op 23 15 clear clear JJ cord-019051-gtruu1op 23 16 . . . cord-019051-gtruu1op 24 1 It -PRON- PRP cord-019051-gtruu1op 24 2 is be VBZ cord-019051-gtruu1op 24 3 not not RB cord-019051-gtruu1op 24 4 the the DT cord-019051-gtruu1op 24 5 intention intention NN cord-019051-gtruu1op 24 6 of of IN cord-019051-gtruu1op 24 7 this this DT cord-019051-gtruu1op 24 8 chapter chapter NN cord-019051-gtruu1op 24 9 to to TO cord-019051-gtruu1op 24 10 comprehensively comprehensively RB cord-019051-gtruu1op 24 11 review review VB cord-019051-gtruu1op 24 12 the the DT cord-019051-gtruu1op 24 13 virology virology NN cord-019051-gtruu1op 24 14 of of IN cord-019051-gtruu1op 24 15 all all PDT cord-019051-gtruu1op 24 16 the the DT cord-019051-gtruu1op 24 17 viruses virus NNS cord-019051-gtruu1op 24 18 that that WDT cord-019051-gtruu1op 24 19 cause cause VBP cord-019051-gtruu1op 24 20 or or CC cord-019051-gtruu1op 24 21 potentially potentially RB cord-019051-gtruu1op 24 22 cause cause VB cord-019051-gtruu1op 24 23 respiratory respiratory JJ cord-019051-gtruu1op 24 24 tract tract NN cord-019051-gtruu1op 24 25 infections infection NNS cord-019051-gtruu1op 24 26 . . . cord-019051-gtruu1op 25 1 The the DT cord-019051-gtruu1op 25 2 chap chap NN cord-019051-gtruu1op 25 3 - - HYPH cord-019051-gtruu1op 25 4 ter ter NN cord-019051-gtruu1op 25 5 focuses focus VBZ cord-019051-gtruu1op 25 6 on on IN cord-019051-gtruu1op 25 7 some some DT cord-019051-gtruu1op 25 8 pathogens pathogen NNS cord-019051-gtruu1op 25 9 that that WDT cord-019051-gtruu1op 25 10 are be VBP cord-019051-gtruu1op 25 11 linked link VBN cord-019051-gtruu1op 25 12 to to IN cord-019051-gtruu1op 25 13 common common JJ cord-019051-gtruu1op 25 14 cold cold NN cord-019051-gtruu1op 25 15 . . . cord-019051-gtruu1op 26 1 The the DT cord-019051-gtruu1op 26 2 list list NN cord-019051-gtruu1op 26 3 of of IN cord-019051-gtruu1op 26 4 viruses virus NNS cord-019051-gtruu1op 26 5 described describe VBN cord-019051-gtruu1op 26 6 includes include VBZ cord-019051-gtruu1op 26 7 rhinovirus rhinovirus NN cord-019051-gtruu1op 26 8 , , , cord-019051-gtruu1op 26 9 respiratory respiratory JJ cord-019051-gtruu1op 26 10 syncytial syncytial JJ cord-019051-gtruu1op 26 11 virus virus NN cord-019051-gtruu1op 26 12 , , , cord-019051-gtruu1op 26 13 parainfluenza parainfluenza NNP cord-019051-gtruu1op 26 14 virus virus NNP cord-019051-gtruu1op 26 15 , , , cord-019051-gtruu1op 26 16 adenovirus adenovirus NN cord-019051-gtruu1op 26 17 , , , cord-019051-gtruu1op 26 18 metapneumovirus metapneumovirus NN cord-019051-gtruu1op 26 19 and and CC cord-019051-gtruu1op 26 20 coronavirus coronavirus NN cord-019051-gtruu1op 26 21 . . . cord-019051-gtruu1op 27 1 Bocavirus Bocavirus NNP cord-019051-gtruu1op 27 2 is be VBZ cord-019051-gtruu1op 27 3 discussed discuss VBN cord-019051-gtruu1op 27 4 as as IN cord-019051-gtruu1op 27 5 an an DT cord-019051-gtruu1op 27 6 example example NN cord-019051-gtruu1op 27 7 of of IN cord-019051-gtruu1op 27 8 a a DT cord-019051-gtruu1op 27 9 newly newly RB cord-019051-gtruu1op 27 10 identified identify VBN cord-019051-gtruu1op 27 11 pathogen pathogen NN cord-019051-gtruu1op 27 12 with with IN cord-019051-gtruu1op 27 13 a a DT cord-019051-gtruu1op 27 14 less less RBR cord-019051-gtruu1op 27 15 established established JJ cord-019051-gtruu1op 27 16 role role NN cord-019051-gtruu1op 27 17 in in IN cord-019051-gtruu1op 27 18 the the DT cord-019051-gtruu1op 27 19 etiology etiology NN cord-019051-gtruu1op 27 20 and and CC cord-019051-gtruu1op 27 21 pathogenesis pathogenesis NN cord-019051-gtruu1op 27 22 of of IN cord-019051-gtruu1op 27 23 common common JJ cord-019051-gtruu1op 27 24 cold cold NN cord-019051-gtruu1op 27 25 . . . cord-019051-gtruu1op 28 1 Influenza influenza NN cord-019051-gtruu1op 28 2 virus virus NN cord-019051-gtruu1op 28 3 does do VBZ cord-019051-gtruu1op 28 4 not not RB cord-019051-gtruu1op 28 5 cause cause VB cord-019051-gtruu1op 28 6 what what WP cord-019051-gtruu1op 28 7 is be VBZ cord-019051-gtruu1op 28 8 defined define VBN cord-019051-gtruu1op 28 9 as as IN cord-019051-gtruu1op 28 10 common common JJ cord-019051-gtruu1op 28 11 cold cold NN cord-019051-gtruu1op 28 12 , , , cord-019051-gtruu1op 28 13 but but CC cord-019051-gtruu1op 28 14 is be VBZ cord-019051-gtruu1op 28 15 associated associate VBN cord-019051-gtruu1op 28 16 with with IN cord-019051-gtruu1op 28 17 respiratory respiratory JJ cord-019051-gtruu1op 28 18 disease disease NN cord-019051-gtruu1op 28 19 and and CC cord-019051-gtruu1op 28 20 the the DT cord-019051-gtruu1op 28 21 clinical clinical JJ cord-019051-gtruu1op 28 22 picture picture NN cord-019051-gtruu1op 28 23 of of IN cord-019051-gtruu1op 28 24 mild mild JJ cord-019051-gtruu1op 28 25 influenza influenza NN cord-019051-gtruu1op 28 26 frequently frequently RB cord-019051-gtruu1op 28 27 overlaps overlap VBZ cord-019051-gtruu1op 28 28 with with IN cord-019051-gtruu1op 28 29 that that DT cord-019051-gtruu1op 28 30 of of IN cord-019051-gtruu1op 28 31 the the DT cord-019051-gtruu1op 28 32 common common JJ cord-019051-gtruu1op 28 33 cold cold NN cord-019051-gtruu1op 28 34 . . . cord-019051-gtruu1op 29 1 Therefore therefore RB cord-019051-gtruu1op 29 2 , , , cord-019051-gtruu1op 29 3 influenza influenza NN cord-019051-gtruu1op 29 4 viruses virus NNS cord-019051-gtruu1op 29 5 are be VBP cord-019051-gtruu1op 29 6 briefly briefly RB cord-019051-gtruu1op 29 7 described describe VBN cord-019051-gtruu1op 29 8 in in IN cord-019051-gtruu1op 29 9 this this DT cord-019051-gtruu1op 29 10 chapter chapter NN cord-019051-gtruu1op 29 11 . . . cord-019051-gtruu1op 30 1 For for IN cord-019051-gtruu1op 30 2 details detail NNS cord-019051-gtruu1op 30 3 on on IN cord-019051-gtruu1op 30 4 the the DT cord-019051-gtruu1op 30 5 biology biology NN cord-019051-gtruu1op 30 6 of of IN cord-019051-gtruu1op 30 7 the the DT cord-019051-gtruu1op 30 8 individual individual JJ cord-019051-gtruu1op 30 9 viruses virus NNS cord-019051-gtruu1op 30 10 and and CC cord-019051-gtruu1op 30 11 their -PRON- PRP$ cord-019051-gtruu1op 30 12 role role NN cord-019051-gtruu1op 30 13 in in IN cord-019051-gtruu1op 30 14 pathogenesis pathogenesis NN cord-019051-gtruu1op 30 15 of of IN cord-019051-gtruu1op 30 16 respiratory respiratory JJ cord-019051-gtruu1op 30 17 diseases disease NNS cord-019051-gtruu1op 30 18 further further RB cord-019051-gtruu1op 30 19 reading reading NN cord-019051-gtruu1op 30 20 of of IN cord-019051-gtruu1op 30 21 standard standard JJ cord-019051-gtruu1op 30 22 literature literature NN cord-019051-gtruu1op 30 23 and and CC cord-019051-gtruu1op 30 24 text text NN cord-019051-gtruu1op 30 25 books book NNS cord-019051-gtruu1op 30 26 of of IN cord-019051-gtruu1op 30 27 virology virology NN cord-019051-gtruu1op 30 28 is be VBZ cord-019051-gtruu1op 30 29 recommended recommend VBN cord-019051-gtruu1op 30 30 . . . cord-019051-gtruu1op 31 1 Viruses virus NNS cord-019051-gtruu1op 31 2 with with IN cord-019051-gtruu1op 31 3 an an DT cord-019051-gtruu1op 31 4 established establish VBN cord-019051-gtruu1op 31 5 role role NN cord-019051-gtruu1op 31 6 in in IN cord-019051-gtruu1op 31 7 common common JJ cord-019051-gtruu1op 31 8 cold cold NN cord-019051-gtruu1op 31 9 are be VBP cord-019051-gtruu1op 31 10 rhinoviruses rhinovirus NNS cord-019051-gtruu1op 31 11 , , , cord-019051-gtruu1op 31 12 adenoviruses adenovirus NNS cord-019051-gtruu1op 31 13 , , , cord-019051-gtruu1op 31 14 parainfluenza parainfluenza NNP cord-019051-gtruu1op 31 15 viruses virus NNS cord-019051-gtruu1op 31 16 , , , cord-019051-gtruu1op 31 17 coronaviruses coronaviruse NNS cord-019051-gtruu1op 31 18 and and CC cord-019051-gtruu1op 31 19 the the DT cord-019051-gtruu1op 31 20 respiratory respiratory JJ cord-019051-gtruu1op 31 21 syncytial syncytial JJ cord-019051-gtruu1op 31 22 virus virus NN cord-019051-gtruu1op 31 23 , , , cord-019051-gtruu1op 31 24 and and CC cord-019051-gtruu1op 31 25 these these DT cord-019051-gtruu1op 31 26 are be VBP cord-019051-gtruu1op 31 27 reviewed review VBN cord-019051-gtruu1op 31 28 in in IN cord-019051-gtruu1op 31 29 greater great JJR cord-019051-gtruu1op 31 30 detail detail NN cord-019051-gtruu1op 31 31 here here RB cord-019051-gtruu1op 31 32 . . . cord-019051-gtruu1op 32 1 Their -PRON- PRP$ cord-019051-gtruu1op 32 2 structure structure NN cord-019051-gtruu1op 32 3 and and CC cord-019051-gtruu1op 32 4 replication replication NN cord-019051-gtruu1op 32 5 , , , cord-019051-gtruu1op 32 6 the the DT cord-019051-gtruu1op 32 7 transmission transmission NN cord-019051-gtruu1op 32 8 and and CC cord-019051-gtruu1op 32 9 epidemiology epidemiology NN cord-019051-gtruu1op 32 10 and and CC cord-019051-gtruu1op 32 11 the the DT cord-019051-gtruu1op 32 12 clinical clinical JJ cord-019051-gtruu1op 32 13 symptoms symptom NNS cord-019051-gtruu1op 32 14 are be VBP cord-019051-gtruu1op 32 15 described describe VBN cord-019051-gtruu1op 32 16 . . . cord-019051-gtruu1op 33 1 In in IN cord-019051-gtruu1op 33 2 addition addition NN cord-019051-gtruu1op 33 3 , , , cord-019051-gtruu1op 33 4 some some DT cord-019051-gtruu1op 33 5 brief brief JJ cord-019051-gtruu1op 33 6 comments comment NNS cord-019051-gtruu1op 33 7 about about IN cord-019051-gtruu1op 33 8 current current JJ cord-019051-gtruu1op 33 9 models model NNS cord-019051-gtruu1op 33 10 of of IN cord-019051-gtruu1op 33 11 pathogenesis pathogenesis NN cord-019051-gtruu1op 33 12 and and CC cord-019051-gtruu1op 33 13 animal animal NN cord-019051-gtruu1op 33 14 models model NNS cord-019051-gtruu1op 33 15 , , , cord-019051-gtruu1op 33 16 respectively respectively RB cord-019051-gtruu1op 33 17 , , , cord-019051-gtruu1op 33 18 complete complete VB cord-019051-gtruu1op 33 19 the the DT cord-019051-gtruu1op 33 20 respective respective JJ cord-019051-gtruu1op 33 21 subchapters subchapter NNS cord-019051-gtruu1op 33 22 . . . cord-019051-gtruu1op 34 1 Table table NN cord-019051-gtruu1op 34 2 1 1 CD cord-019051-gtruu1op 34 3 provides provide VBZ cord-019051-gtruu1op 34 4 an an DT cord-019051-gtruu1op 34 5 overview overview NN cord-019051-gtruu1op 34 6 of of IN cord-019051-gtruu1op 34 7 the the DT cord-019051-gtruu1op 34 8 viruses virus NNS cord-019051-gtruu1op 34 9 that that WDT cord-019051-gtruu1op 34 10 cause cause VBP cord-019051-gtruu1op 34 11 respiratory respiratory JJ cord-019051-gtruu1op 34 12 tract tract NN cord-019051-gtruu1op 34 13 infections infection NNS cord-019051-gtruu1op 34 14 and and CC cord-019051-gtruu1op 34 15 that that WDT cord-019051-gtruu1op 34 16 do do VBP cord-019051-gtruu1op 34 17 , , , cord-019051-gtruu1op 34 18 or or CC cord-019051-gtruu1op 34 19 may may MD cord-019051-gtruu1op 34 20 , , , cord-019051-gtruu1op 34 21 play play VB cord-019051-gtruu1op 34 22 a a DT cord-019051-gtruu1op 34 23 role role NN cord-019051-gtruu1op 34 24 as as IN cord-019051-gtruu1op 34 25 a a DT cord-019051-gtruu1op 34 26 cause cause NN cord-019051-gtruu1op 34 27 or or CC cord-019051-gtruu1op 34 28 in in IN cord-019051-gtruu1op 34 29 the the DT cord-019051-gtruu1op 34 30 pathogenesis pathogenesis NN cord-019051-gtruu1op 34 31 of of IN cord-019051-gtruu1op 34 32 common common JJ cord-019051-gtruu1op 34 33 cold cold NN cord-019051-gtruu1op 34 34 . . . cord-019051-gtruu1op 35 1 A a DT cord-019051-gtruu1op 35 2 number number NN cord-019051-gtruu1op 35 3 of of IN cord-019051-gtruu1op 35 4 viruses virus NNS cord-019051-gtruu1op 35 5 are be VBP cord-019051-gtruu1op 35 6 frequently frequently RB cord-019051-gtruu1op 35 7 co co VBN cord-019051-gtruu1op 35 8 - - VBN cord-019051-gtruu1op 35 9 detected detect VBN cord-019051-gtruu1op 35 10 with with IN cord-019051-gtruu1op 35 11 other other JJ cord-019051-gtruu1op 35 12 viruses virus NNS cord-019051-gtruu1op 35 13 in in IN cord-019051-gtruu1op 35 14 humans human NNS cord-019051-gtruu1op 35 15 with with IN cord-019051-gtruu1op 35 16 respiratory respiratory JJ cord-019051-gtruu1op 35 17 diseases disease NNS cord-019051-gtruu1op 35 18 . . . cord-019051-gtruu1op 36 1 Therefore therefore RB cord-019051-gtruu1op 36 2 , , , cord-019051-gtruu1op 36 3 the the DT cord-019051-gtruu1op 36 4 viral viral JJ cord-019051-gtruu1op 36 5 etiology etiology NN cord-019051-gtruu1op 36 6 and and CC cord-019051-gtruu1op 36 7 the the DT cord-019051-gtruu1op 36 8 role role NN cord-019051-gtruu1op 36 9 of of IN cord-019051-gtruu1op 36 10 viruses virus NNS cord-019051-gtruu1op 36 11 in in IN cord-019051-gtruu1op 36 12 the the DT cord-019051-gtruu1op 36 13 pathogenesis pathogenesis NN cord-019051-gtruu1op 36 14 of of IN cord-019051-gtruu1op 36 15 common common JJ cord-019051-gtruu1op 36 16 cold cold NN cord-019051-gtruu1op 36 17 is be VBZ cord-019051-gtruu1op 36 18 complex complex JJ cord-019051-gtruu1op 36 19 and and CC cord-019051-gtruu1op 36 20 it -PRON- PRP cord-019051-gtruu1op 36 21 is be VBZ cord-019051-gtruu1op 36 22 safe safe JJ cord-019051-gtruu1op 36 23 to to TO cord-019051-gtruu1op 36 24 say say VB cord-019051-gtruu1op 36 25 , , , cord-019051-gtruu1op 36 26 not not RB cord-019051-gtruu1op 36 27 fully fully RB cord-019051-gtruu1op 36 28 understood understand VBN cord-019051-gtruu1op 36 29 for for IN cord-019051-gtruu1op 36 30 each each DT cord-019051-gtruu1op 36 31 and and CC cord-019051-gtruu1op 36 32 every every DT cord-019051-gtruu1op 36 33 virus virus NN cord-019051-gtruu1op 36 34 that that WDT cord-019051-gtruu1op 36 35 is be VBZ cord-019051-gtruu1op 36 36 linked link VBN cord-019051-gtruu1op 36 37 to to IN cord-019051-gtruu1op 36 38 respiratory respiratory JJ cord-019051-gtruu1op 36 39 tract tract NN cord-019051-gtruu1op 36 40 infection infection NN cord-019051-gtruu1op 36 41 . . . cord-019051-gtruu1op 37 1 Recent recent JJ cord-019051-gtruu1op 37 2 developments development NNS cord-019051-gtruu1op 37 3 in in IN cord-019051-gtruu1op 37 4 the the DT cord-019051-gtruu1op 37 5 field field NN cord-019051-gtruu1op 37 6 of of IN cord-019051-gtruu1op 37 7 antivirals antiviral NNS cord-019051-gtruu1op 37 8 are be VBP cord-019051-gtruu1op 37 9 described describe VBN cord-019051-gtruu1op 37 10 in in IN cord-019051-gtruu1op 37 11 the the DT cord-019051-gtruu1op 37 12 chapter chapter NN cord-019051-gtruu1op 37 13 by by IN cord-019051-gtruu1op 37 14 Tom Tom NNP cord-019051-gtruu1op 37 15 Jefferson Jefferson NNP cord-019051-gtruu1op 37 16 in in IN cord-019051-gtruu1op 37 17 this this DT cord-019051-gtruu1op 37 18 book book NN cord-019051-gtruu1op 37 19 . . . cord-019051-gtruu1op 38 1 Rhinoviruses rhinovirus NNS cord-019051-gtruu1op 38 2 cause cause VBP cord-019051-gtruu1op 38 3 the the DT cord-019051-gtruu1op 38 4 vast vast JJ cord-019051-gtruu1op 38 5 majority majority NN cord-019051-gtruu1op 38 6 of of IN cord-019051-gtruu1op 38 7 the the DT cord-019051-gtruu1op 38 8 common common JJ cord-019051-gtruu1op 38 9 colds cold NNS cord-019051-gtruu1op 38 10 in in IN cord-019051-gtruu1op 38 11 humans human NNS cord-019051-gtruu1op 38 12 . . . cord-019051-gtruu1op 39 1 Although although IN cord-019051-gtruu1op 39 2 the the DT cord-019051-gtruu1op 39 3 infection infection NN cord-019051-gtruu1op 39 4 usually usually RB cord-019051-gtruu1op 39 5 is be VBZ cord-019051-gtruu1op 39 6 self self NN cord-019051-gtruu1op 39 7 limiting limit VBG cord-019051-gtruu1op 39 8 and and CC cord-019051-gtruu1op 39 9 the the DT cord-019051-gtruu1op 39 10 symptoms symptom NNS cord-019051-gtruu1op 39 11 of of IN cord-019051-gtruu1op 39 12 the the DT cord-019051-gtruu1op 39 13 disease disease NN cord-019051-gtruu1op 39 14 are be VBP cord-019051-gtruu1op 39 15 mild mild JJ cord-019051-gtruu1op 39 16 in in IN cord-019051-gtruu1op 39 17 healthy healthy JJ cord-019051-gtruu1op 39 18 adults adult NNS cord-019051-gtruu1op 39 19 , , , cord-019051-gtruu1op 39 20 rhinovirus rhinovirus NN cord-019051-gtruu1op 39 21 infections infection NNS cord-019051-gtruu1op 39 22 may may MD cord-019051-gtruu1op 39 23 cause cause VB cord-019051-gtruu1op 39 24 serious serious JJ cord-019051-gtruu1op 39 25 illness illness NN cord-019051-gtruu1op 39 26 in in IN cord-019051-gtruu1op 39 27 children child NNS cord-019051-gtruu1op 39 28 or or CC cord-019051-gtruu1op 39 29 patients patient NNS cord-019051-gtruu1op 39 30 with with IN cord-019051-gtruu1op 39 31 pre pre JJ cord-019051-gtruu1op 39 32 - - JJ cord-019051-gtruu1op 39 33 existing existing JJ cord-019051-gtruu1op 39 34 medical medical JJ cord-019051-gtruu1op 39 35 problems problem NNS cord-019051-gtruu1op 39 36 [ [ -LRB- cord-019051-gtruu1op 39 37 1 1 CD cord-019051-gtruu1op 39 38 ] ] -RRB- cord-019051-gtruu1op 39 39 . . . cord-019051-gtruu1op 40 1 Taxonomy taxonomy NN cord-019051-gtruu1op 40 2 , , , cord-019051-gtruu1op 40 3 structure structure NN cord-019051-gtruu1op 40 4 and and CC cord-019051-gtruu1op 40 5 replication replication NN cord-019051-gtruu1op 40 6 Rhinoviruses Rhinoviruses NNP cord-019051-gtruu1op 40 7 More More JJR cord-019051-gtruu1op 40 8 than than IN cord-019051-gtruu1op 40 9 100 100 CD cord-019051-gtruu1op 40 10 serotypes serotype NNS cord-019051-gtruu1op 40 11 , , , cord-019051-gtruu1op 40 12 strains strain NNS cord-019051-gtruu1op 40 13 and and CC cord-019051-gtruu1op 40 14 isolates isolate NNS cord-019051-gtruu1op 40 15 of of IN cord-019051-gtruu1op 40 16 RV RV NNP cord-019051-gtruu1op 40 17 have have VBP cord-019051-gtruu1op 40 18 been be VBN cord-019051-gtruu1op 40 19 isolated isolate VBN cord-019051-gtruu1op 40 20 from from IN cord-019051-gtruu1op 40 21 humans human NNS cord-019051-gtruu1op 40 22 . . . cord-019051-gtruu1op 41 1 Two two CD cord-019051-gtruu1op 41 2 human human JJ cord-019051-gtruu1op 41 3 RV rv NN cord-019051-gtruu1op 41 4 species specie NNS cord-019051-gtruu1op 41 5 have have VBP cord-019051-gtruu1op 41 6 been be VBN cord-019051-gtruu1op 41 7 described describe VBN cord-019051-gtruu1op 41 8 : : : cord-019051-gtruu1op 41 9 Human human JJ cord-019051-gtruu1op 41 10 rhinovirus rhinovirus NN cord-019051-gtruu1op 41 11 ( ( -LRB- cord-019051-gtruu1op 41 12 HRV HRV NNP cord-019051-gtruu1op 41 13 ) ) -RRB- cord-019051-gtruu1op 42 1 A A NNP cord-019051-gtruu1op 42 2 and and CC cord-019051-gtruu1op 42 3 B. B. NNP cord-019051-gtruu1op 42 4 Eighteen Eighteen NNP cord-019051-gtruu1op 42 5 serotypes serotype NNS cord-019051-gtruu1op 42 6 and and CC cord-019051-gtruu1op 42 7 2 2 CD cord-019051-gtruu1op 42 8 subtypes subtype NNS cord-019051-gtruu1op 42 9 ( ( -LRB- cord-019051-gtruu1op 42 10 HRV HRV NNP cord-019051-gtruu1op 42 11 1A 1a NN cord-019051-gtruu1op 42 12 and and CC cord-019051-gtruu1op 42 13 1B 1b LS cord-019051-gtruu1op 42 14 ) ) -RRB- cord-019051-gtruu1op 42 15 belong belong VBP cord-019051-gtruu1op 42 16 to to IN cord-019051-gtruu1op 42 17 HRV HRV NNP cord-019051-gtruu1op 42 18 A. A. NNP cord-019051-gtruu1op 42 19 Five five CD cord-019051-gtruu1op 42 20 serotypes serotype NNS cord-019051-gtruu1op 42 21 are be VBP cord-019051-gtruu1op 42 22 assigned assign VBN cord-019051-gtruu1op 42 23 to to IN cord-019051-gtruu1op 42 24 HRV HRV NNP cord-019051-gtruu1op 42 25 B B NNP cord-019051-gtruu1op 42 26 and and CC cord-019051-gtruu1op 42 27 82 82 CD cord-019051-gtruu1op 42 28 serotypes serotype NNS cord-019051-gtruu1op 42 29 are be VBP cord-019051-gtruu1op 42 30 not not RB cord-019051-gtruu1op 42 31 yet yet RB cord-019051-gtruu1op 42 32 assigned assign VBN cord-019051-gtruu1op 42 33 to to IN cord-019051-gtruu1op 42 34 a a DT cord-019051-gtruu1op 42 35 species species NN cord-019051-gtruu1op 42 36 including include VBG cord-019051-gtruu1op 42 37 bovine bovine JJ cord-019051-gtruu1op 42 38 rhinoviruses rhinovirus NNS cord-019051-gtruu1op 42 39 ( ( -LRB- cord-019051-gtruu1op 42 40 BRV BRV NNP cord-019051-gtruu1op 42 41 ) ) -RRB- cord-019051-gtruu1op 42 42 1 1 CD cord-019051-gtruu1op 42 43 - - SYM cord-019051-gtruu1op 42 44 3 3 CD cord-019051-gtruu1op 42 45 . . . cord-019051-gtruu1op 43 1 RV RV NNP cord-019051-gtruu1op 43 2 are be VBP cord-019051-gtruu1op 43 3 non non JJ cord-019051-gtruu1op 43 4 - - JJ cord-019051-gtruu1op 43 5 enveloped enveloped JJ cord-019051-gtruu1op 43 6 viruses virus NNS cord-019051-gtruu1op 43 7 with with IN cord-019051-gtruu1op 43 8 an an DT cord-019051-gtruu1op 43 9 icosahedral icosahedral JJ cord-019051-gtruu1op 43 10 symmetry symmetry NN cord-019051-gtruu1op 43 11 . . . cord-019051-gtruu1op 44 1 The the DT cord-019051-gtruu1op 44 2 virus virus NN cord-019051-gtruu1op 44 3 is be VBZ cord-019051-gtruu1op 44 4 small small JJ cord-019051-gtruu1op 44 5 and and CC cord-019051-gtruu1op 44 6 has have VBZ cord-019051-gtruu1op 44 7 a a DT cord-019051-gtruu1op 44 8 diameter diameter NN cord-019051-gtruu1op 44 9 of of IN cord-019051-gtruu1op 44 10 approximately approximately RB cord-019051-gtruu1op 44 11 30 30 CD cord-019051-gtruu1op 44 12 nm nm NN cord-019051-gtruu1op 44 13 . . . cord-019051-gtruu1op 45 1 Four four CD cord-019051-gtruu1op 45 2 capsid capsid NN cord-019051-gtruu1op 45 3 proteins protein NNS cord-019051-gtruu1op 45 4 , , , cord-019051-gtruu1op 45 5 VP1 VP1 NNP cord-019051-gtruu1op 45 6 - - HYPH cord-019051-gtruu1op 45 7 4 4 CD cord-019051-gtruu1op 45 8 have have VBP cord-019051-gtruu1op 45 9 been be VBN cord-019051-gtruu1op 45 10 described describe VBN cord-019051-gtruu1op 45 11 . . . cord-019051-gtruu1op 46 1 A a DT cord-019051-gtruu1op 46 2 protomer protomer NN cord-019051-gtruu1op 46 3 is be VBZ cord-019051-gtruu1op 46 4 composed compose VBN cord-019051-gtruu1op 46 5 of of IN cord-019051-gtruu1op 46 6 one one CD cord-019051-gtruu1op 46 7 copy copy NN cord-019051-gtruu1op 46 8 of of IN cord-019051-gtruu1op 46 9 VP1 VP1 NNP cord-019051-gtruu1op 46 10 , , , cord-019051-gtruu1op 46 11 VP3 VP3 NNP cord-019051-gtruu1op 46 12 and and CC cord-019051-gtruu1op 46 13 VP0 VP0 NNP cord-019051-gtruu1op 46 14 ( ( -LRB- cord-019051-gtruu1op 46 15 a a DT cord-019051-gtruu1op 46 16 precursor precursor NN cord-019051-gtruu1op 46 17 where where WRB cord-019051-gtruu1op 46 18 VP4 vp4 JJ cord-019051-gtruu1op 46 19 and and CC cord-019051-gtruu1op 46 20 VP2 VP2 NNP cord-019051-gtruu1op 46 21 are be VBP cord-019051-gtruu1op 46 22 covalently covalently RB cord-019051-gtruu1op 46 23 linked link VBN cord-019051-gtruu1op 46 24 ) ) -RRB- cord-019051-gtruu1op 46 25 . . . cord-019051-gtruu1op 47 1 Cleavage cleavage NN cord-019051-gtruu1op 47 2 of of IN cord-019051-gtruu1op 47 3 VP0 VP0 NNP cord-019051-gtruu1op 47 4 is be VBZ cord-019051-gtruu1op 47 5 the the DT cord-019051-gtruu1op 47 6 final final JJ cord-019051-gtruu1op 47 7 step step NN cord-019051-gtruu1op 47 8 of of IN cord-019051-gtruu1op 47 9 the the DT cord-019051-gtruu1op 47 10 assembly assembly NN cord-019051-gtruu1op 47 11 process process NN cord-019051-gtruu1op 47 12 [ [ -LRB- cord-019051-gtruu1op 47 13 3 3 CD cord-019051-gtruu1op 47 14 ] ] -RRB- cord-019051-gtruu1op 47 15 . . . cord-019051-gtruu1op 48 1 One one CD cord-019051-gtruu1op 48 2 or or CC cord-019051-gtruu1op 48 3 two two CD cord-019051-gtruu1op 48 4 copies copy NNS cord-019051-gtruu1op 48 5 of of IN cord-019051-gtruu1op 48 6 VP0 VP0 NNP cord-019051-gtruu1op 48 7 will will MD cord-019051-gtruu1op 48 8 remain remain VB cord-019051-gtruu1op 48 9 uncleaved uncleaved JJ cord-019051-gtruu1op 48 10 ; ; : cord-019051-gtruu1op 48 11 no no DT cord-019051-gtruu1op 48 12 role role NN cord-019051-gtruu1op 48 13 for for IN cord-019051-gtruu1op 48 14 this this DT cord-019051-gtruu1op 48 15 uncleaved uncleave VBN cord-019051-gtruu1op 48 16 VP0 VP0 NNP cord-019051-gtruu1op 48 17 has have VBZ cord-019051-gtruu1op 48 18 been be VBN cord-019051-gtruu1op 48 19 established establish VBN cord-019051-gtruu1op 48 20 yet yet RB cord-019051-gtruu1op 48 21 . . . cord-019051-gtruu1op 49 1 Five five CD cord-019051-gtruu1op 49 2 protomers protomer NNS cord-019051-gtruu1op 49 3 are be VBP cord-019051-gtruu1op 49 4 arranged arrange VBN cord-019051-gtruu1op 49 5 symmetrically symmetrically RB cord-019051-gtruu1op 49 6 about about IN cord-019051-gtruu1op 49 7 a a DT cord-019051-gtruu1op 49 8 fivefold fivefold JJ cord-019051-gtruu1op 49 9 axis axis NN cord-019051-gtruu1op 49 10 , , , cord-019051-gtruu1op 49 11 forming form VBG cord-019051-gtruu1op 49 12 a a DT cord-019051-gtruu1op 49 13 pentamer pentamer NN cord-019051-gtruu1op 49 14 that that WDT cord-019051-gtruu1op 49 15 represents represent VBZ cord-019051-gtruu1op 49 16 a a DT cord-019051-gtruu1op 49 17 corner corner NN cord-019051-gtruu1op 49 18 of of IN cord-019051-gtruu1op 49 19 the the DT cord-019051-gtruu1op 49 20 icosahedron icosahedron NN cord-019051-gtruu1op 49 21 . . . cord-019051-gtruu1op 50 1 The the DT cord-019051-gtruu1op 50 2 capsid capsid NN cord-019051-gtruu1op 50 3 is be VBZ cord-019051-gtruu1op 50 4 formed form VBN cord-019051-gtruu1op 50 5 by by IN cord-019051-gtruu1op 50 6 12 12 CD cord-019051-gtruu1op 50 7 pentamers pentamer NNS cord-019051-gtruu1op 50 8 . . . cord-019051-gtruu1op 51 1 RV rv NN cord-019051-gtruu1op 51 2 have have VBP cord-019051-gtruu1op 51 3 , , , cord-019051-gtruu1op 51 4 similar similar JJ cord-019051-gtruu1op 51 5 to to IN cord-019051-gtruu1op 51 6 human human JJ cord-019051-gtruu1op 51 7 enteroviruses enterovirus NNS cord-019051-gtruu1op 51 8 , , , cord-019051-gtruu1op 51 9 the the DT cord-019051-gtruu1op 51 10 same same JJ cord-019051-gtruu1op 51 11 comparatively comparatively RB cord-019051-gtruu1op 51 12 uneven uneven JJ cord-019051-gtruu1op 51 13 surface surface NN cord-019051-gtruu1op 51 14 with with IN cord-019051-gtruu1op 51 15 its -PRON- PRP$ cord-019051-gtruu1op 51 16 characteristic characteristic JJ cord-019051-gtruu1op 51 17 canyon canyon NN cord-019051-gtruu1op 51 18 around around IN cord-019051-gtruu1op 51 19 the the DT cord-019051-gtruu1op 51 20 fivefold fivefold JJ cord-019051-gtruu1op 51 21 axis axis NN cord-019051-gtruu1op 51 22 [ [ -LRB- cord-019051-gtruu1op 51 23 4 4 CD cord-019051-gtruu1op 51 24 ] ] -RRB- cord-019051-gtruu1op 51 25 . . . cord-019051-gtruu1op 52 1 The the DT cord-019051-gtruu1op 52 2 canyon canyon NN cord-019051-gtruu1op 52 3 serves serve VBZ cord-019051-gtruu1op 52 4 as as IN cord-019051-gtruu1op 52 5 an an DT cord-019051-gtruu1op 52 6 attachment attachment NN cord-019051-gtruu1op 52 7 site site NN cord-019051-gtruu1op 52 8 for for IN cord-019051-gtruu1op 52 9 the the DT cord-019051-gtruu1op 52 10 cell cell NN cord-019051-gtruu1op 52 11 receptor receptor NN cord-019051-gtruu1op 52 12 [ [ -LRB- cord-019051-gtruu1op 52 13 5 5 CD cord-019051-gtruu1op 52 14 ] ] -RRB- cord-019051-gtruu1op 52 15 . . . cord-019051-gtruu1op 53 1 In in IN cord-019051-gtruu1op 53 2 CsCl CsCl NNP cord-019051-gtruu1op 53 3 , , , cord-019051-gtruu1op 53 4 RV RV NNP cord-019051-gtruu1op 53 5 have have VBP cord-019051-gtruu1op 53 6 a a DT cord-019051-gtruu1op 53 7 buoyant buoyant JJ cord-019051-gtruu1op 53 8 density density NN cord-019051-gtruu1op 53 9 of of IN cord-019051-gtruu1op 53 10 1.38 1.38 CD cord-019051-gtruu1op 53 11 - - SYM cord-019051-gtruu1op 53 12 1.42 1.42 CD cord-019051-gtruu1op 53 13 g/ g/ NNPS cord-019051-gtruu1op 53 14 cm cm NNS cord-019051-gtruu1op 53 15 3 3 CD cord-019051-gtruu1op 53 16 . . . cord-019051-gtruu1op 54 1 Virions virion NNS cord-019051-gtruu1op 54 2 are be VBP cord-019051-gtruu1op 54 3 unstable unstable JJ cord-019051-gtruu1op 54 4 at at IN cord-019051-gtruu1op 54 5 a a DT cord-019051-gtruu1op 54 6 pH ph NN cord-019051-gtruu1op 54 7 below below IN cord-019051-gtruu1op 54 8 5 5 CD cord-019051-gtruu1op 54 9 - - SYM cord-019051-gtruu1op 54 10 6 6 CD cord-019051-gtruu1op 54 11 , , , cord-019051-gtruu1op 54 12 a a DT cord-019051-gtruu1op 54 13 feature feature NN cord-019051-gtruu1op 54 14 , , , cord-019051-gtruu1op 54 15 which which WDT cord-019051-gtruu1op 54 16 distinguishes distinguish VBZ cord-019051-gtruu1op 54 17 RV RV NNP cord-019051-gtruu1op 54 18 from from IN cord-019051-gtruu1op 54 19 other other JJ cord-019051-gtruu1op 54 20 enteroviruses enterovirus NNS cord-019051-gtruu1op 54 21 . . . cord-019051-gtruu1op 55 1 However however RB cord-019051-gtruu1op 55 2 , , , cord-019051-gtruu1op 55 3 as as IN cord-019051-gtruu1op 55 4 they -PRON- PRP cord-019051-gtruu1op 55 5 are be VBP cord-019051-gtruu1op 55 6 non non JJ cord-019051-gtruu1op 55 7 - - JJ cord-019051-gtruu1op 55 8 enveloped enveloped JJ cord-019051-gtruu1op 55 9 viruses virus NNS cord-019051-gtruu1op 55 10 , , , cord-019051-gtruu1op 55 11 RV RV NNP cord-019051-gtruu1op 55 12 are be VBP cord-019051-gtruu1op 55 13 stable stable JJ cord-019051-gtruu1op 55 14 against against IN cord-019051-gtruu1op 55 15 detergents detergent NNS cord-019051-gtruu1op 55 16 and and CC cord-019051-gtruu1op 55 17 most most JJS cord-019051-gtruu1op 55 18 organic organic JJ cord-019051-gtruu1op 55 19 solvents solvent NNS cord-019051-gtruu1op 55 20 . . . cord-019051-gtruu1op 56 1 On on IN cord-019051-gtruu1op 56 2 the the DT cord-019051-gtruu1op 56 3 other other JJ cord-019051-gtruu1op 56 4 hand hand NN cord-019051-gtruu1op 56 5 , , , cord-019051-gtruu1op 56 6 alcohol alcohol NN cord-019051-gtruu1op 56 7 and and CC cord-019051-gtruu1op 56 8 phenol phenol NN cord-019051-gtruu1op 56 9 are be VBP cord-019051-gtruu1op 56 10 effective effective JJ cord-019051-gtruu1op 56 11 virucidal virucidal JJ cord-019051-gtruu1op 56 12 agents agent NNS cord-019051-gtruu1op 56 13 . . . cord-019051-gtruu1op 57 1 The the DT cord-019051-gtruu1op 57 2 RV RV NNP cord-019051-gtruu1op 57 3 genome genome NN cord-019051-gtruu1op 57 4 is be VBZ cord-019051-gtruu1op 57 5 organized organize VBN cord-019051-gtruu1op 57 6 as as IN cord-019051-gtruu1op 57 7 a a DT cord-019051-gtruu1op 57 8 single single RB cord-019051-gtruu1op 57 9 - - HYPH cord-019051-gtruu1op 57 10 stranded strand VBN cord-019051-gtruu1op 57 11 positive positive JJ cord-019051-gtruu1op 57 12 - - HYPH cord-019051-gtruu1op 57 13 sense sense NN cord-019051-gtruu1op 57 14 RNA RNA NNP cord-019051-gtruu1op 57 15 of of IN cord-019051-gtruu1op 57 16 approximately approximately RB cord-019051-gtruu1op 57 17 7100 7100 CD cord-019051-gtruu1op 57 18 - - HYPH cord-019051-gtruu1op 57 19 7200 7200 CD cord-019051-gtruu1op 57 20 nucleotides nucleotide NNS cord-019051-gtruu1op 57 21 in in IN cord-019051-gtruu1op 57 22 length length NN cord-019051-gtruu1op 57 23 with with IN cord-019051-gtruu1op 57 24 its -PRON- PRP$ cord-019051-gtruu1op 57 25 5 5 CD cord-019051-gtruu1op 57 26 ' ' '' cord-019051-gtruu1op 57 27 terminus terminus NN cord-019051-gtruu1op 57 28 covalently covalently RB cord-019051-gtruu1op 57 29 linked link VBN cord-019051-gtruu1op 57 30 to to IN cord-019051-gtruu1op 57 31 a a DT cord-019051-gtruu1op 57 32 small small JJ cord-019051-gtruu1op 57 33 protein protein NN cord-019051-gtruu1op 57 34 , , , cord-019051-gtruu1op 57 35 VPg VPg NNS cord-019051-gtruu1op 57 36 . . . cord-019051-gtruu1op 58 1 The the DT cord-019051-gtruu1op 58 2 5'-untranslated 5'-untranslated CD cord-019051-gtruu1op 58 3 region region NN cord-019051-gtruu1op 58 4 ( ( -LRB- cord-019051-gtruu1op 58 5 UTR UTR NNP cord-019051-gtruu1op 58 6 ) ) -RRB- cord-019051-gtruu1op 58 7 of of IN cord-019051-gtruu1op 58 8 approximately approximately RB cord-019051-gtruu1op 58 9 0.65 0.65 CD cord-019051-gtruu1op 58 10 kb kb NNP cord-019051-gtruu1op 58 11 is be VBZ cord-019051-gtruu1op 58 12 shorter short JJR cord-019051-gtruu1op 58 13 than than IN cord-019051-gtruu1op 58 14 that that DT cord-019051-gtruu1op 58 15 of of IN cord-019051-gtruu1op 58 16 other other JJ cord-019051-gtruu1op 58 17 enteroviruses enterovirus NNS cord-019051-gtruu1op 58 18 , , , cord-019051-gtruu1op 58 19 owing owe VBG cord-019051-gtruu1op 58 20 to to IN cord-019051-gtruu1op 58 21 a a DT cord-019051-gtruu1op 58 22 deletion deletion NN cord-019051-gtruu1op 58 23 of of IN cord-019051-gtruu1op 58 24 approximately approximately RB cord-019051-gtruu1op 58 25 100 100 CD cord-019051-gtruu1op 58 26 nucleotides nucleotide NNS cord-019051-gtruu1op 58 27 between between IN cord-019051-gtruu1op 58 28 the the DT cord-019051-gtruu1op 58 29 internal internal JJ cord-019051-gtruu1op 58 30 ribosomal ribosomal JJ cord-019051-gtruu1op 58 31 entry entry NN cord-019051-gtruu1op 58 32 site site NN cord-019051-gtruu1op 58 33 ( ( -LRB- cord-019051-gtruu1op 58 34 IRES IRES NNP cord-019051-gtruu1op 58 35 ) ) -RRB- cord-019051-gtruu1op 58 36 and and CC cord-019051-gtruu1op 58 37 the the DT cord-019051-gtruu1op 58 38 translation translation NN cord-019051-gtruu1op 58 39 start start NN cord-019051-gtruu1op 58 40 site site NN cord-019051-gtruu1op 58 41 . . . cord-019051-gtruu1op 59 1 One one CD cord-019051-gtruu1op 59 2 open open JJ cord-019051-gtruu1op 59 3 reading reading NN cord-019051-gtruu1op 59 4 frame frame NN cord-019051-gtruu1op 59 5 ( ( -LRB- cord-019051-gtruu1op 59 6 ORF ORF NNP cord-019051-gtruu1op 59 7 ) ) -RRB- cord-019051-gtruu1op 59 8 of of IN cord-019051-gtruu1op 59 9 about about IN cord-019051-gtruu1op 59 10 2150 2150 CD cord-019051-gtruu1op 59 11 codons codon NNS cord-019051-gtruu1op 59 12 , , , cord-019051-gtruu1op 59 13 a a DT cord-019051-gtruu1op 59 14 3'-UTR 3'-utr CD cord-019051-gtruu1op 59 15 of of IN cord-019051-gtruu1op 59 16 approximately approximately RB cord-019051-gtruu1op 59 17 40 40 CD cord-019051-gtruu1op 59 18 nucleotides nucleotide NNS cord-019051-gtruu1op 59 19 and and CC cord-019051-gtruu1op 59 20 a a DT cord-019051-gtruu1op 59 21 3 3 CD cord-019051-gtruu1op 59 22 ' ' NN cord-019051-gtruu1op 59 23 poly(A poly(a JJ cord-019051-gtruu1op 59 24 ) ) -RRB- cord-019051-gtruu1op 59 25 tail tail NN cord-019051-gtruu1op 59 26 complete complete VB cord-019051-gtruu1op 59 27 the the DT cord-019051-gtruu1op 59 28 structure structure NN cord-019051-gtruu1op 59 29 of of IN cord-019051-gtruu1op 59 30 the the DT cord-019051-gtruu1op 59 31 genome genome NN cord-019051-gtruu1op 59 32 . . . cord-019051-gtruu1op 60 1 RV RV NNP cord-019051-gtruu1op 60 2 have have VBP cord-019051-gtruu1op 60 3 a a DT cord-019051-gtruu1op 60 4 characteristic characteristic JJ cord-019051-gtruu1op 60 5 nucleotide nucleotide JJ cord-019051-gtruu1op 60 6 composition composition NN cord-019051-gtruu1op 60 7 with with IN cord-019051-gtruu1op 60 8 a a DT cord-019051-gtruu1op 60 9 preponderance preponderance NN cord-019051-gtruu1op 60 10 of of IN cord-019051-gtruu1op 60 11 A a NN cord-019051-gtruu1op 60 12 and and CC cord-019051-gtruu1op 60 13 U u NN cord-019051-gtruu1op 60 14 , , , cord-019051-gtruu1op 60 15 particularly particularly RB cord-019051-gtruu1op 60 16 in in IN cord-019051-gtruu1op 60 17 the the DT cord-019051-gtruu1op 60 18 third third JJ cord-019051-gtruu1op 60 19 position position NN cord-019051-gtruu1op 60 20 of of IN cord-019051-gtruu1op 60 21 the the DT cord-019051-gtruu1op 60 22 codons codon NNS cord-019051-gtruu1op 60 23 . . . cord-019051-gtruu1op 61 1 The the DT cord-019051-gtruu1op 61 2 genome genome NN cord-019051-gtruu1op 61 3 is be VBZ cord-019051-gtruu1op 61 4 fully fully RB cord-019051-gtruu1op 61 5 sequenced sequence VBN cord-019051-gtruu1op 61 6 and and CC cord-019051-gtruu1op 61 7 has have VBZ cord-019051-gtruu1op 61 8 the the DT cord-019051-gtruu1op 61 9 accession accession NN cord-019051-gtruu1op 61 10 number number NN cord-019051-gtruu1op 61 11 Replication Replication NNP cord-019051-gtruu1op 61 12 is be VBZ cord-019051-gtruu1op 61 13 initiated initiate VBN cord-019051-gtruu1op 61 14 through through IN cord-019051-gtruu1op 61 15 attachment attachment NN cord-019051-gtruu1op 61 16 to to IN cord-019051-gtruu1op 61 17 the the DT cord-019051-gtruu1op 61 18 cell cell NN cord-019051-gtruu1op 61 19 receptor receptor NN cord-019051-gtruu1op 61 20 . . . cord-019051-gtruu1op 62 1 For for IN cord-019051-gtruu1op 62 2 most most JJS cord-019051-gtruu1op 62 3 RV rv NN cord-019051-gtruu1op 62 4 serotypes serotype NNS cord-019051-gtruu1op 62 5 this this DT cord-019051-gtruu1op 62 6 is be VBZ cord-019051-gtruu1op 62 7 intercellular intercellular JJ cord-019051-gtruu1op 62 8 adhesion adhesion NN cord-019051-gtruu1op 62 9 molecule-1 molecule-1 NN cord-019051-gtruu1op 62 10 ( ( -LRB- cord-019051-gtruu1op 62 11 ICAM-1 ICAM-1 NNP cord-019051-gtruu1op 62 12 ) ) -RRB- cord-019051-gtruu1op 62 13 [ [ -LRB- cord-019051-gtruu1op 62 14 6 6 CD cord-019051-gtruu1op 62 15 , , , cord-019051-gtruu1op 62 16 7 7 CD cord-019051-gtruu1op 62 17 ] ] -RRB- cord-019051-gtruu1op 62 18 . . . cord-019051-gtruu1op 63 1 It -PRON- PRP cord-019051-gtruu1op 63 2 is be VBZ cord-019051-gtruu1op 63 3 hypothesized hypothesize VBN cord-019051-gtruu1op 63 4 that that IN cord-019051-gtruu1op 63 5 the the DT cord-019051-gtruu1op 63 6 viral viral JJ cord-019051-gtruu1op 63 7 canyon canyon NN cord-019051-gtruu1op 63 8 structure structure NN cord-019051-gtruu1op 63 9 releases release VBZ cord-019051-gtruu1op 63 10 a a DT cord-019051-gtruu1op 63 11 lipid lipid NN cord-019051-gtruu1op 63 12 moiety moiety NN cord-019051-gtruu1op 63 13 upon upon IN cord-019051-gtruu1op 63 14 ICAM-1 icam-1 NN cord-019051-gtruu1op 63 15 binding binding NN cord-019051-gtruu1op 63 16 , , , cord-019051-gtruu1op 63 17 which which WDT cord-019051-gtruu1op 63 18 , , , cord-019051-gtruu1op 63 19 in in IN cord-019051-gtruu1op 63 20 turn turn NN cord-019051-gtruu1op 63 21 , , , cord-019051-gtruu1op 63 22 leads lead VBZ cord-019051-gtruu1op 63 23 to to IN cord-019051-gtruu1op 63 24 a a DT cord-019051-gtruu1op 63 25 change change NN cord-019051-gtruu1op 63 26 in in IN cord-019051-gtruu1op 63 27 conformation conformation NN cord-019051-gtruu1op 63 28 , , , cord-019051-gtruu1op 63 29 destabilization destabilization NN cord-019051-gtruu1op 63 30 and and CC cord-019051-gtruu1op 63 31 the the DT cord-019051-gtruu1op 63 32 release release NN cord-019051-gtruu1op 63 33 of of IN cord-019051-gtruu1op 63 34 the the DT cord-019051-gtruu1op 63 35 viral viral JJ cord-019051-gtruu1op 63 36 RNA RNA NNP cord-019051-gtruu1op 63 37 into into IN cord-019051-gtruu1op 63 38 the the DT cord-019051-gtruu1op 63 39 cytoplasm cytoplasm NN cord-019051-gtruu1op 63 40 [ [ -LRB- cord-019051-gtruu1op 63 41 8 8 CD cord-019051-gtruu1op 63 42 ] ] -RRB- cord-019051-gtruu1op 63 43 . . . cord-019051-gtruu1op 64 1 RV RV NNP cord-019051-gtruu1op 64 2 shut shut VBD cord-019051-gtruu1op 64 3 off off RP cord-019051-gtruu1op 64 4 host host NN cord-019051-gtruu1op 64 5 cell cell NN cord-019051-gtruu1op 64 6 protein protein NN cord-019051-gtruu1op 64 7 synthesis synthesis NN cord-019051-gtruu1op 64 8 by by IN cord-019051-gtruu1op 64 9 inactivating inactivate VBG cord-019051-gtruu1op 64 10 the the DT cord-019051-gtruu1op 64 11 cap cap NN cord-019051-gtruu1op 64 12 binding bind VBG cord-019051-gtruu1op 64 13 complex complex NN cord-019051-gtruu1op 64 14 . . . cord-019051-gtruu1op 65 1 Their -PRON- PRP$ cord-019051-gtruu1op 65 2 IRES IRES NNP cord-019051-gtruu1op 65 3 allows allow VBZ cord-019051-gtruu1op 65 4 them -PRON- PRP cord-019051-gtruu1op 65 5 to to TO cord-019051-gtruu1op 65 6 replicate replicate VB cord-019051-gtruu1op 65 7 despite despite IN cord-019051-gtruu1op 65 8 this this DT cord-019051-gtruu1op 65 9 inactivation inactivation NN cord-019051-gtruu1op 65 10 . . . cord-019051-gtruu1op 66 1 The the DT cord-019051-gtruu1op 66 2 RNA RNA NNP cord-019051-gtruu1op 66 3 serves serve VBZ cord-019051-gtruu1op 66 4 as as IN cord-019051-gtruu1op 66 5 a a DT cord-019051-gtruu1op 66 6 messenger messenger NN cord-019051-gtruu1op 66 7 RNA RNA NNP cord-019051-gtruu1op 66 8 encoding encode VBG cord-019051-gtruu1op 66 9 a a DT cord-019051-gtruu1op 66 10 single single JJ cord-019051-gtruu1op 66 11 polyprotein polyprotein NN cord-019051-gtruu1op 66 12 which which WDT cord-019051-gtruu1op 66 13 is be VBZ cord-019051-gtruu1op 66 14 cleaved cleave VBN cord-019051-gtruu1op 66 15 post post NN cord-019051-gtruu1op 66 16 - - NN cord-019051-gtruu1op 66 17 translationally translationally RB cord-019051-gtruu1op 66 18 by by IN cord-019051-gtruu1op 66 19 virus virus NN cord-019051-gtruu1op 66 20 - - HYPH cord-019051-gtruu1op 66 21 encoded encode VBN cord-019051-gtruu1op 66 22 proteases protease NNS cord-019051-gtruu1op 66 23 . . . cord-019051-gtruu1op 67 1 Once once RB cord-019051-gtruu1op 67 2 the the DT cord-019051-gtruu1op 67 3 first first JJ cord-019051-gtruu1op 67 4 round round NN cord-019051-gtruu1op 67 5 of of IN cord-019051-gtruu1op 67 6 translation translation NN cord-019051-gtruu1op 67 7 and and CC cord-019051-gtruu1op 67 8 subsequent subsequent JJ cord-019051-gtruu1op 67 9 processing processing NN cord-019051-gtruu1op 67 10 is be VBZ cord-019051-gtruu1op 67 11 complete complete JJ cord-019051-gtruu1op 67 12 a a DT cord-019051-gtruu1op 67 13 3D 3d JJ cord-019051-gtruu1op 67 14 pol pol NN cord-019051-gtruu1op 67 15 RNA RNA NNP cord-019051-gtruu1op 67 16 - - HYPH cord-019051-gtruu1op 67 17 dependent dependent JJ cord-019051-gtruu1op 67 18 RNA RNA NNP cord-019051-gtruu1op 67 19 polymerase polymerase NN cord-019051-gtruu1op 67 20 produces produce VBZ cord-019051-gtruu1op 67 21 negative negative JJ cord-019051-gtruu1op 67 22 - - HYPH cord-019051-gtruu1op 67 23 sense sense NN cord-019051-gtruu1op 67 24 RNA RNA NNP cord-019051-gtruu1op 67 25 from from IN cord-019051-gtruu1op 67 26 the the DT cord-019051-gtruu1op 67 27 genomic genomic JJ cord-019051-gtruu1op 67 28 template template NN cord-019051-gtruu1op 67 29 , , , cord-019051-gtruu1op 67 30 which which WDT cord-019051-gtruu1op 67 31 in in IN cord-019051-gtruu1op 67 32 turn turn NN cord-019051-gtruu1op 67 33 serve serve VBP cord-019051-gtruu1op 67 34 as as IN cord-019051-gtruu1op 67 35 template template NN cord-019051-gtruu1op 67 36 for for IN cord-019051-gtruu1op 67 37 the the DT cord-019051-gtruu1op 67 38 production production NN cord-019051-gtruu1op 67 39 of of IN cord-019051-gtruu1op 67 40 positive positive JJ cord-019051-gtruu1op 67 41 - - HYPH cord-019051-gtruu1op 67 42 sense sense NN cord-019051-gtruu1op 67 43 genomic genomic JJ cord-019051-gtruu1op 67 44 RNA RNA NNP cord-019051-gtruu1op 67 45 . . . cord-019051-gtruu1op 68 1 The the DT cord-019051-gtruu1op 68 2 synthesis synthesis NN cord-019051-gtruu1op 68 3 of of IN cord-019051-gtruu1op 68 4 a a DT cord-019051-gtruu1op 68 5 single single JJ cord-019051-gtruu1op 68 6 virus virus NN cord-019051-gtruu1op 68 7 polyprotein polyprotein NN cord-019051-gtruu1op 68 8 requires require VBZ cord-019051-gtruu1op 68 9 post post JJ cord-019051-gtruu1op 68 10 - - JJ cord-019051-gtruu1op 68 11 translational translational JJ cord-019051-gtruu1op 68 12 processing processing NN cord-019051-gtruu1op 68 13 to to TO cord-019051-gtruu1op 68 14 facilitate facilitate VB cord-019051-gtruu1op 68 15 subsequent subsequent JJ cord-019051-gtruu1op 68 16 steps step NNS cord-019051-gtruu1op 68 17 in in IN cord-019051-gtruu1op 68 18 viral viral JJ cord-019051-gtruu1op 68 19 replication replication NN cord-019051-gtruu1op 68 20 . . . cord-019051-gtruu1op 69 1 At at RB cord-019051-gtruu1op 69 2 least least RBS cord-019051-gtruu1op 69 3 two two CD cord-019051-gtruu1op 69 4 proteolytic proteolytic JJ cord-019051-gtruu1op 69 5 activities activity NNS cord-019051-gtruu1op 69 6 are be VBP cord-019051-gtruu1op 69 7 encoded encode VBN cord-019051-gtruu1op 69 8 by by IN cord-019051-gtruu1op 69 9 the the DT cord-019051-gtruu1op 69 10 virus virus NN cord-019051-gtruu1op 69 11 : : : cord-019051-gtruu1op 69 12 2A 2A NNP cord-019051-gtruu1op 69 13 pro pro NNP cord-019051-gtruu1op 69 14 performs perform VBZ cord-019051-gtruu1op 69 15 the the DT cord-019051-gtruu1op 69 16 first first JJ cord-019051-gtruu1op 69 17 cleavage cleavage NN cord-019051-gtruu1op 69 18 releasing release VBG cord-019051-gtruu1op 69 19 capsid capsid NN cord-019051-gtruu1op 69 20 precursors precursor NNS cord-019051-gtruu1op 69 21 and and CC cord-019051-gtruu1op 69 22 3C 3c NN cord-019051-gtruu1op 69 23 pro pro NNP cord-019051-gtruu1op 69 24 catalyzes catalyze VBZ cord-019051-gtruu1op 69 25 most most JJS cord-019051-gtruu1op 69 26 other other JJ cord-019051-gtruu1op 69 27 cleavage cleavage NN cord-019051-gtruu1op 69 28 reactions reaction NNS cord-019051-gtruu1op 69 29 . . . cord-019051-gtruu1op 70 1 The the DT cord-019051-gtruu1op 70 2 protease protease NN cord-019051-gtruu1op 70 3 has have VBZ cord-019051-gtruu1op 70 4 a a DT cord-019051-gtruu1op 70 5 trypsin trypsin NN cord-019051-gtruu1op 70 6 - - HYPH cord-019051-gtruu1op 70 7 like like JJ cord-019051-gtruu1op 70 8 structure structure NN cord-019051-gtruu1op 70 9 but but CC cord-019051-gtruu1op 70 10 the the DT cord-019051-gtruu1op 70 11 active active JJ cord-019051-gtruu1op 70 12 site site NN cord-019051-gtruu1op 70 13 of of IN cord-019051-gtruu1op 70 14 the the DT cord-019051-gtruu1op 70 15 enzyme enzyme NN cord-019051-gtruu1op 70 16 is be VBZ cord-019051-gtruu1op 70 17 a a DT cord-019051-gtruu1op 70 18 cysteine cysteine NN cord-019051-gtruu1op 70 19 sulfydryl sulfydryl NN cord-019051-gtruu1op 70 20 [ [ -LRB- cord-019051-gtruu1op 70 21 9 9 CD cord-019051-gtruu1op 70 22 ] ] -RRB- cord-019051-gtruu1op 70 23 . . . cord-019051-gtruu1op 71 1 RV RV NNP cord-019051-gtruu1op 71 2 are be VBP cord-019051-gtruu1op 71 3 transmitted transmit VBN cord-019051-gtruu1op 71 4 mainly mainly RB cord-019051-gtruu1op 71 5 by by IN cord-019051-gtruu1op 71 6 direct direct JJ cord-019051-gtruu1op 71 7 contact contact NN cord-019051-gtruu1op 71 8 and and CC cord-019051-gtruu1op 71 9 less less RBR cord-019051-gtruu1op 71 10 frequently frequently RB cord-019051-gtruu1op 71 11 through through IN cord-019051-gtruu1op 71 12 aerosols aerosol NNS cord-019051-gtruu1op 71 13 ( ( -LRB- cord-019051-gtruu1op 71 14 for for IN cord-019051-gtruu1op 71 15 details detail NNS cord-019051-gtruu1op 71 16 see see VBP cord-019051-gtruu1op 71 17 the the DT cord-019051-gtruu1op 71 18 chapter chapter NN cord-019051-gtruu1op 71 19 by by IN cord-019051-gtruu1op 71 20 Diane Diane NNP cord-019051-gtruu1op 71 21 Pappas Pappas NNP cord-019051-gtruu1op 71 22 and and CC cord-019051-gtruu1op 71 23 Owen Owen NNP cord-019051-gtruu1op 71 24 Hendley Hendley NNP cord-019051-gtruu1op 71 25 ) ) -RRB- cord-019051-gtruu1op 71 26 . . . cord-019051-gtruu1op 72 1 Virus virus NN cord-019051-gtruu1op 72 2 can can MD cord-019051-gtruu1op 72 3 frequently frequently RB cord-019051-gtruu1op 72 4 be be VB cord-019051-gtruu1op 72 5 isolated isolate VBN cord-019051-gtruu1op 72 6 from from IN cord-019051-gtruu1op 72 7 the the DT cord-019051-gtruu1op 72 8 hands hand NNS cord-019051-gtruu1op 72 9 of of IN cord-019051-gtruu1op 72 10 an an DT cord-019051-gtruu1op 72 11 infected infected JJ cord-019051-gtruu1op 72 12 individual individual NN cord-019051-gtruu1op 72 13 and and CC cord-019051-gtruu1op 72 14 is be VBZ cord-019051-gtruu1op 72 15 transmitted transmit VBN cord-019051-gtruu1op 72 16 to to IN cord-019051-gtruu1op 72 17 other other JJ cord-019051-gtruu1op 72 18 individuals individual NNS cord-019051-gtruu1op 72 19 or or CC cord-019051-gtruu1op 72 20 to to IN cord-019051-gtruu1op 72 21 objects object NNS cord-019051-gtruu1op 72 22 in in IN cord-019051-gtruu1op 72 23 the the DT cord-019051-gtruu1op 72 24 environment environment NN cord-019051-gtruu1op 72 25 . . . cord-019051-gtruu1op 73 1 During during IN cord-019051-gtruu1op 73 2 RV RV NNP cord-019051-gtruu1op 73 3 infection infection NN cord-019051-gtruu1op 73 4 virus virus NN cord-019051-gtruu1op 73 5 titers titer NNS cord-019051-gtruu1op 73 6 in in IN cord-019051-gtruu1op 73 7 nasal nasal NN cord-019051-gtruu1op 73 8 secretions secretion NNS cord-019051-gtruu1op 73 9 are be VBP cord-019051-gtruu1op 73 10 as as RB cord-019051-gtruu1op 73 11 high high JJ cord-019051-gtruu1op 73 12 as as IN cord-019051-gtruu1op 73 13 10 10 CD cord-019051-gtruu1op 73 14 2 2 CD cord-019051-gtruu1op 73 15 -10 -10 SYM cord-019051-gtruu1op 73 16 3 3 CD cord-019051-gtruu1op 73 17 TCID TCID NNP cord-019051-gtruu1op 73 18 50 50 CD cord-019051-gtruu1op 73 19 /ml /ml NFP cord-019051-gtruu1op 73 20 of of IN cord-019051-gtruu1op 73 21 nasal nasal NN cord-019051-gtruu1op 73 22 lavage lavage NN cord-019051-gtruu1op 73 23 fluid fluid NN cord-019051-gtruu1op 73 24 [ [ -LRB- cord-019051-gtruu1op 73 25 10 10 CD cord-019051-gtruu1op 73 26 , , , cord-019051-gtruu1op 73 27 11 11 CD cord-019051-gtruu1op 73 28 ] ] -RRB- cord-019051-gtruu1op 73 29 . . . cord-019051-gtruu1op 74 1 Infection infection NN cord-019051-gtruu1op 74 2 of of IN cord-019051-gtruu1op 74 3 humans human NNS cord-019051-gtruu1op 74 4 is be VBZ cord-019051-gtruu1op 74 5 very very RB cord-019051-gtruu1op 74 6 effective effective JJ cord-019051-gtruu1op 74 7 and and CC cord-019051-gtruu1op 74 8 less less JJR cord-019051-gtruu1op 74 9 RV RV NNP cord-019051-gtruu1op 74 10 may may MD cord-019051-gtruu1op 74 11 be be VB cord-019051-gtruu1op 74 12 needed need VBN cord-019051-gtruu1op 74 13 for for IN cord-019051-gtruu1op 74 14 infection infection NN cord-019051-gtruu1op 74 15 of of IN cord-019051-gtruu1op 74 16 seronegative seronegative JJ cord-019051-gtruu1op 74 17 volunteers volunteer NNS cord-019051-gtruu1op 74 18 by by IN cord-019051-gtruu1op 74 19 nasal nasal NN cord-019051-gtruu1op 74 20 drops drop NNS cord-019051-gtruu1op 74 21 than than IN cord-019051-gtruu1op 74 22 needed need VBN cord-019051-gtruu1op 74 23 for for IN cord-019051-gtruu1op 74 24 infection infection NN cord-019051-gtruu1op 74 25 of of IN cord-019051-gtruu1op 74 26 a a DT cord-019051-gtruu1op 74 27 human human JJ cord-019051-gtruu1op 74 28 embryonic embryonic JJ cord-019051-gtruu1op 74 29 fibroblast fibroblast NN cord-019051-gtruu1op 74 30 tissue tissue NN cord-019051-gtruu1op 74 31 culture culture NN cord-019051-gtruu1op 74 32 [ [ -LRB- cord-019051-gtruu1op 74 33 12 12 CD cord-019051-gtruu1op 74 34 ] ] -RRB- cord-019051-gtruu1op 74 35 . . . cord-019051-gtruu1op 75 1 In in IN cord-019051-gtruu1op 75 2 contrast contrast NN cord-019051-gtruu1op 75 3 , , , cord-019051-gtruu1op 75 4 when when WRB cord-019051-gtruu1op 75 5 the the DT cord-019051-gtruu1op 75 6 same same JJ cord-019051-gtruu1op 75 7 virus virus NN cord-019051-gtruu1op 75 8 was be VBD cord-019051-gtruu1op 75 9 used use VBN cord-019051-gtruu1op 75 10 for for IN cord-019051-gtruu1op 75 11 inhalation inhalation NN cord-019051-gtruu1op 75 12 of of IN cord-019051-gtruu1op 75 13 aerosols aerosol NNS cord-019051-gtruu1op 75 14 a a DT cord-019051-gtruu1op 75 15 20-fold 20-fold JJ cord-019051-gtruu1op 75 16 disparity disparity NN cord-019051-gtruu1op 75 17 in in IN cord-019051-gtruu1op 75 18 infectious infectious JJ cord-019051-gtruu1op 75 19 dose dose NN cord-019051-gtruu1op 75 20 has have VBZ cord-019051-gtruu1op 75 21 been be VBN cord-019051-gtruu1op 75 22 described describe VBN cord-019051-gtruu1op 75 23 [ [ -LRB- cord-019051-gtruu1op 75 24 13 13 CD cord-019051-gtruu1op 75 25 ] ] -RRB- cord-019051-gtruu1op 75 26 , , , cord-019051-gtruu1op 75 27 suggesting suggest VBG cord-019051-gtruu1op 75 28 that that IN cord-019051-gtruu1op 75 29 the the DT cord-019051-gtruu1op 75 30 lower low JJR cord-019051-gtruu1op 75 31 respiratory respiratory JJ cord-019051-gtruu1op 75 32 tract tract NN cord-019051-gtruu1op 75 33 is be VBZ cord-019051-gtruu1op 75 34 less less RBR cord-019051-gtruu1op 75 35 susceptible susceptible JJ cord-019051-gtruu1op 75 36 for for IN cord-019051-gtruu1op 75 37 infection infection NN cord-019051-gtruu1op 75 38 than than IN cord-019051-gtruu1op 75 39 the the DT cord-019051-gtruu1op 75 40 nasopharynx nasopharynx NN cord-019051-gtruu1op 75 41 . . . cord-019051-gtruu1op 76 1 After after IN cord-019051-gtruu1op 76 2 a a DT cord-019051-gtruu1op 76 3 short short JJ cord-019051-gtruu1op 76 4 incubation incubation NN cord-019051-gtruu1op 76 5 period period NN cord-019051-gtruu1op 76 6 of of IN cord-019051-gtruu1op 76 7 1 1 CD cord-019051-gtruu1op 76 8 - - SYM cord-019051-gtruu1op 76 9 4 4 CD cord-019051-gtruu1op 76 10 days day NNS cord-019051-gtruu1op 76 11 virus virus NN cord-019051-gtruu1op 76 12 is be VBZ cord-019051-gtruu1op 76 13 shed shed VBN cord-019051-gtruu1op 76 14 , , , cord-019051-gtruu1op 76 15 peaks peak NNS cord-019051-gtruu1op 76 16 after after IN cord-019051-gtruu1op 76 17 another another DT cord-019051-gtruu1op 76 18 2 2 CD cord-019051-gtruu1op 76 19 - - SYM cord-019051-gtruu1op 76 20 3 3 CD cord-019051-gtruu1op 76 21 days day NNS cord-019051-gtruu1op 76 22 , , , cord-019051-gtruu1op 76 23 and and CC cord-019051-gtruu1op 76 24 declines decline NNS cord-019051-gtruu1op 76 25 thereafter thereafter RB cord-019051-gtruu1op 76 26 [ [ -LRB- cord-019051-gtruu1op 76 27 13 13 CD cord-019051-gtruu1op 76 28 , , , cord-019051-gtruu1op 76 29 14 14 CD cord-019051-gtruu1op 76 30 ] ] -RRB- cord-019051-gtruu1op 76 31 . . . cord-019051-gtruu1op 77 1 The the DT cord-019051-gtruu1op 77 2 primary primary JJ cord-019051-gtruu1op 77 3 site site NN cord-019051-gtruu1op 77 4 of of IN cord-019051-gtruu1op 77 5 viral viral JJ cord-019051-gtruu1op 77 6 replication replication NN cord-019051-gtruu1op 77 7 is be VBZ cord-019051-gtruu1op 77 8 ciliated ciliated JJ cord-019051-gtruu1op 77 9 epithelial epithelial JJ cord-019051-gtruu1op 77 10 cells cell NNS cord-019051-gtruu1op 77 11 as as IN cord-019051-gtruu1op 77 12 detected detect VBN cord-019051-gtruu1op 77 13 by by IN cord-019051-gtruu1op 77 14 in in IN cord-019051-gtruu1op 77 15 situ situ NN cord-019051-gtruu1op 77 16 hybridization hybridization NN cord-019051-gtruu1op 77 17 [ [ -LRB- cord-019051-gtruu1op 77 18 15 15 CD cord-019051-gtruu1op 77 19 ] ] -RRB- cord-019051-gtruu1op 77 20 . . . cord-019051-gtruu1op 78 1 The the DT cord-019051-gtruu1op 78 2 histopathology histopathology NN cord-019051-gtruu1op 78 3 of of IN cord-019051-gtruu1op 78 4 RV RV NNP cord-019051-gtruu1op 78 5 infection infection NN cord-019051-gtruu1op 78 6 is be VBZ cord-019051-gtruu1op 78 7 not not RB cord-019051-gtruu1op 78 8 as as RB cord-019051-gtruu1op 78 9 yet yet RB cord-019051-gtruu1op 78 10 very very RB cord-019051-gtruu1op 78 11 detailed detailed JJ cord-019051-gtruu1op 78 12 . . . cord-019051-gtruu1op 79 1 Nasal nasal JJ cord-019051-gtruu1op 79 2 mucosa mucosa JJ cord-019051-gtruu1op 79 3 biopsies biopsy NNS cord-019051-gtruu1op 79 4 reveal reveal VBP cord-019051-gtruu1op 79 5 only only RB cord-019051-gtruu1op 79 6 few few JJ cord-019051-gtruu1op 79 7 or or CC cord-019051-gtruu1op 79 8 no no DT cord-019051-gtruu1op 79 9 histopathological histopathological JJ cord-019051-gtruu1op 79 10 abnormalities abnormality NNS cord-019051-gtruu1op 79 11 despite despite IN cord-019051-gtruu1op 79 12 active active JJ cord-019051-gtruu1op 79 13 virus virus NN cord-019051-gtruu1op 79 14 shedding shed VBG cord-019051-gtruu1op 79 15 . . . cord-019051-gtruu1op 80 1 Explant explant JJ cord-019051-gtruu1op 80 2 cultures culture NNS cord-019051-gtruu1op 80 3 inoculated inoculate VBN cord-019051-gtruu1op 80 4 with with IN cord-019051-gtruu1op 80 5 rhinovirus rhinovirus NN cord-019051-gtruu1op 80 6 failed fail VBD cord-019051-gtruu1op 80 7 to to TO cord-019051-gtruu1op 80 8 develop develop VB cord-019051-gtruu1op 80 9 cytopathic cytopathic JJ cord-019051-gtruu1op 80 10 effects effect NNS cord-019051-gtruu1op 80 11 ( ( -LRB- cord-019051-gtruu1op 80 12 CPE CPE NNP cord-019051-gtruu1op 80 13 ) ) -RRB- cord-019051-gtruu1op 80 14 [ [ -LRB- cord-019051-gtruu1op 80 15 16 16 CD cord-019051-gtruu1op 80 16 ] ] -RRB- cord-019051-gtruu1op 80 17 . . . cord-019051-gtruu1op 81 1 Biopsies biopsy NNS cord-019051-gtruu1op 81 2 showed show VBD cord-019051-gtruu1op 81 3 marked marked JJ cord-019051-gtruu1op 81 4 edema edema NN cord-019051-gtruu1op 81 5 of of IN cord-019051-gtruu1op 81 6 connective connective JJ cord-019051-gtruu1op 81 7 tissue tissue NN cord-019051-gtruu1op 81 8 , , , cord-019051-gtruu1op 81 9 sparse sparse JJ cord-019051-gtruu1op 81 10 infiltration infiltration NN cord-019051-gtruu1op 81 11 of of IN cord-019051-gtruu1op 81 12 inflammatory inflammatory JJ cord-019051-gtruu1op 81 13 cells cell NNS cord-019051-gtruu1op 81 14 , , , cord-019051-gtruu1op 81 15 hyperemia hyperemia NN cord-019051-gtruu1op 81 16 and and CC cord-019051-gtruu1op 81 17 exudation exudation NN cord-019051-gtruu1op 81 18 of of IN cord-019051-gtruu1op 81 19 seromucous seromucous JJ cord-019051-gtruu1op 81 20 fluids fluid NNS cord-019051-gtruu1op 81 21 [ [ -LRB- cord-019051-gtruu1op 81 22 17 17 CD cord-019051-gtruu1op 81 23 ] ] -RRB- cord-019051-gtruu1op 81 24 [ [ -LRB- cord-019051-gtruu1op 81 25 18 18 CD cord-019051-gtruu1op 81 26 ] ] -RRB- cord-019051-gtruu1op 81 27 [ [ -LRB- cord-019051-gtruu1op 81 28 19 19 CD cord-019051-gtruu1op 81 29 ] ] -RRB- cord-019051-gtruu1op 81 30 . . . cord-019051-gtruu1op 82 1 Infection infection NN cord-019051-gtruu1op 82 2 of of IN cord-019051-gtruu1op 82 3 bovine bovine JJ cord-019051-gtruu1op 82 4 tracheal tracheal JJ cord-019051-gtruu1op 82 5 organ organ NN cord-019051-gtruu1op 82 6 cultures culture NNS cord-019051-gtruu1op 82 7 with with IN cord-019051-gtruu1op 82 8 BRV BRV NNP cord-019051-gtruu1op 82 9 leads lead VBZ cord-019051-gtruu1op 82 10 to to IN cord-019051-gtruu1op 82 11 shedding shed VBG cord-019051-gtruu1op 82 12 of of IN cord-019051-gtruu1op 82 13 ciliated ciliated JJ cord-019051-gtruu1op 82 14 cells cell NNS cord-019051-gtruu1op 82 15 . . . cord-019051-gtruu1op 83 1 It -PRON- PRP cord-019051-gtruu1op 83 2 has have VBZ cord-019051-gtruu1op 83 3 been be VBN cord-019051-gtruu1op 83 4 suggested suggest VBN cord-019051-gtruu1op 83 5 that that IN cord-019051-gtruu1op 83 6 the the DT cord-019051-gtruu1op 83 7 immune immune JJ cord-019051-gtruu1op 83 8 response response NN cord-019051-gtruu1op 83 9 of of IN cord-019051-gtruu1op 83 10 the the DT cord-019051-gtruu1op 83 11 host host NN cord-019051-gtruu1op 83 12 contributes contribute VBZ cord-019051-gtruu1op 83 13 to to IN cord-019051-gtruu1op 83 14 the the DT cord-019051-gtruu1op 83 15 symptom symptom NN cord-019051-gtruu1op 83 16 complex complex NN cord-019051-gtruu1op 83 17 . . . cord-019051-gtruu1op 84 1 Increased increase VBN cord-019051-gtruu1op 84 2 concentrations concentration NNS cord-019051-gtruu1op 84 3 of of IN cord-019051-gtruu1op 84 4 the the DT cord-019051-gtruu1op 84 5 pro pro JJ cord-019051-gtruu1op 84 6 - - JJ cord-019051-gtruu1op 84 7 inflammatory inflammatory JJ cord-019051-gtruu1op 84 8 cytokines cytokine NNS cord-019051-gtruu1op 84 9 IL-8 il-8 RB cord-019051-gtruu1op 84 10 , , , cord-019051-gtruu1op 84 11 IL-1 IL-1 NNP cord-019051-gtruu1op 84 12 and and CC cord-019051-gtruu1op 84 13 IL-6 IL-6 NNP cord-019051-gtruu1op 84 14 [ [ -LRB- cord-019051-gtruu1op 84 15 20 20 CD cord-019051-gtruu1op 84 16 ] ] -RRB- cord-019051-gtruu1op 84 17 [ [ -LRB- cord-019051-gtruu1op 84 18 21 21 CD cord-019051-gtruu1op 84 19 ] ] -RRB- cord-019051-gtruu1op 85 1 [ [ -LRB- cord-019051-gtruu1op 85 2 22 22 CD cord-019051-gtruu1op 85 3 ] ] -RRB- cord-019051-gtruu1op 85 4 have have VBP cord-019051-gtruu1op 85 5 been be VBN cord-019051-gtruu1op 85 6 found find VBN cord-019051-gtruu1op 85 7 in in IN cord-019051-gtruu1op 85 8 nasal nasal JJ cord-019051-gtruu1op 85 9 secretions secretion NNS cord-019051-gtruu1op 85 10 of of IN cord-019051-gtruu1op 85 11 subjects subject NNS cord-019051-gtruu1op 85 12 with with IN cord-019051-gtruu1op 85 13 symptomatic symptomatic JJ cord-019051-gtruu1op 85 14 RV rv NN cord-019051-gtruu1op 85 15 infection infection NN cord-019051-gtruu1op 85 16 . . . cord-019051-gtruu1op 86 1 A a DT cord-019051-gtruu1op 86 2 direct direct JJ cord-019051-gtruu1op 86 3 correlation correlation NN cord-019051-gtruu1op 86 4 between between IN cord-019051-gtruu1op 86 5 concentration concentration NN cord-019051-gtruu1op 86 6 in in IN cord-019051-gtruu1op 86 7 nasal nasal NN cord-019051-gtruu1op 86 8 fluids fluid NNS cord-019051-gtruu1op 86 9 and and CC cord-019051-gtruu1op 86 10 symptom symptom NN cord-019051-gtruu1op 86 11 severity severity NN cord-019051-gtruu1op 86 12 has have VBZ cord-019051-gtruu1op 86 13 been be VBN cord-019051-gtruu1op 86 14 described describe VBN cord-019051-gtruu1op 86 15 for for IN cord-019051-gtruu1op 86 16 IL-6 IL-6 NNP cord-019051-gtruu1op 86 17 [ [ -LRB- cord-019051-gtruu1op 86 18 22 22 CD cord-019051-gtruu1op 86 19 ] ] -RRB- cord-019051-gtruu1op 86 20 . . . cord-019051-gtruu1op 87 1 RV rv NN cord-019051-gtruu1op 87 2 infection infection NN cord-019051-gtruu1op 87 3 is be VBZ cord-019051-gtruu1op 87 4 usually usually RB cord-019051-gtruu1op 87 5 accompanied accompany VBN cord-019051-gtruu1op 87 6 by by IN cord-019051-gtruu1op 87 7 the the DT cord-019051-gtruu1op 87 8 typical typical JJ cord-019051-gtruu1op 87 9 common common JJ cord-019051-gtruu1op 87 10 cold cold JJ cord-019051-gtruu1op 87 11 symptoms symptom NNS cord-019051-gtruu1op 87 12 : : : cord-019051-gtruu1op 87 13 nasal nasal NN cord-019051-gtruu1op 87 14 discharge discharge NN cord-019051-gtruu1op 87 15 and and CC cord-019051-gtruu1op 87 16 obstruction obstruction NN cord-019051-gtruu1op 87 17 , , , cord-019051-gtruu1op 87 18 sneezing sneezing NN cord-019051-gtruu1op 87 19 , , , cord-019051-gtruu1op 87 20 coughing coughing NN cord-019051-gtruu1op 87 21 , , , cord-019051-gtruu1op 87 22 sore sore JJ cord-019051-gtruu1op 87 23 throat throat NN cord-019051-gtruu1op 87 24 and and CC cord-019051-gtruu1op 87 25 , , , cord-019051-gtruu1op 87 26 less less RBR cord-019051-gtruu1op 87 27 frequently frequently RB cord-019051-gtruu1op 87 28 , , , cord-019051-gtruu1op 87 29 fever fever NN cord-019051-gtruu1op 87 30 . . . cord-019051-gtruu1op 88 1 Gastrointestinal gastrointestinal JJ cord-019051-gtruu1op 88 2 symptoms symptom NNS cord-019051-gtruu1op 88 3 are be VBP cord-019051-gtruu1op 88 4 sometimes sometimes RB cord-019051-gtruu1op 88 5 observed observe VBN cord-019051-gtruu1op 88 6 in in IN cord-019051-gtruu1op 88 7 children child NNS cord-019051-gtruu1op 88 8 . . . cord-019051-gtruu1op 89 1 The the DT cord-019051-gtruu1op 89 2 infection infection NN cord-019051-gtruu1op 89 3 is be VBZ cord-019051-gtruu1op 89 4 usually usually RB cord-019051-gtruu1op 89 5 limited limit VBN cord-019051-gtruu1op 89 6 to to IN cord-019051-gtruu1op 89 7 the the DT cord-019051-gtruu1op 89 8 upper upper JJ cord-019051-gtruu1op 89 9 respiratory respiratory JJ cord-019051-gtruu1op 89 10 tract tract NN cord-019051-gtruu1op 89 11 . . . cord-019051-gtruu1op 90 1 It -PRON- PRP cord-019051-gtruu1op 90 2 is be VBZ cord-019051-gtruu1op 90 3 commonly commonly RB cord-019051-gtruu1op 90 4 believed believe VBN cord-019051-gtruu1op 90 5 that that IN cord-019051-gtruu1op 90 6 RV RV NNP cord-019051-gtruu1op 90 7 infection infection NN cord-019051-gtruu1op 90 8 increases increase VBZ cord-019051-gtruu1op 90 9 the the DT cord-019051-gtruu1op 90 10 risk risk NN cord-019051-gtruu1op 90 11 for for IN cord-019051-gtruu1op 90 12 subsequent subsequent JJ cord-019051-gtruu1op 90 13 or or CC cord-019051-gtruu1op 90 14 secondary secondary JJ cord-019051-gtruu1op 90 15 bacterial bacterial JJ cord-019051-gtruu1op 90 16 infections infection NNS cord-019051-gtruu1op 90 17 . . . cord-019051-gtruu1op 91 1 In in IN cord-019051-gtruu1op 91 2 patients patient NNS cord-019051-gtruu1op 91 3 predisposed predispose VBN cord-019051-gtruu1op 91 4 with with IN cord-019051-gtruu1op 91 5 existing exist VBG cord-019051-gtruu1op 91 6 under under IN cord-019051-gtruu1op 91 7 - - HYPH cord-019051-gtruu1op 91 8 lying lie VBG cord-019051-gtruu1op 91 9 diseases disease NNS cord-019051-gtruu1op 91 10 , , , cord-019051-gtruu1op 91 11 like like IN cord-019051-gtruu1op 91 12 cystic cystic JJ cord-019051-gtruu1op 91 13 fibrosis fibrosis NN cord-019051-gtruu1op 91 14 or or CC cord-019051-gtruu1op 91 15 chronic chronic JJ cord-019051-gtruu1op 91 16 bronchitis bronchitis NN cord-019051-gtruu1op 91 17 , , , cord-019051-gtruu1op 91 18 and and CC cord-019051-gtruu1op 91 19 in in IN cord-019051-gtruu1op 91 20 immunocompromised immunocompromised JJ cord-019051-gtruu1op 91 21 patients patient NNS cord-019051-gtruu1op 91 22 , , , cord-019051-gtruu1op 91 23 elderly elderly JJ cord-019051-gtruu1op 91 24 and and CC cord-019051-gtruu1op 91 25 infants infant NNS cord-019051-gtruu1op 91 26 , , , cord-019051-gtruu1op 91 27 RV RV NNP cord-019051-gtruu1op 91 28 can can MD cord-019051-gtruu1op 91 29 cause cause VB cord-019051-gtruu1op 91 30 serious serious JJ cord-019051-gtruu1op 91 31 infections infection NNS cord-019051-gtruu1op 91 32 of of IN cord-019051-gtruu1op 91 33 the the DT cord-019051-gtruu1op 91 34 lower low JJR cord-019051-gtruu1op 91 35 respiratory respiratory JJ cord-019051-gtruu1op 91 36 tract tract NN cord-019051-gtruu1op 91 37 . . . cord-019051-gtruu1op 92 1 RV rv NN cord-019051-gtruu1op 92 2 infection infection NN cord-019051-gtruu1op 92 3 of of IN cord-019051-gtruu1op 92 4 the the DT cord-019051-gtruu1op 92 5 lower low JJR cord-019051-gtruu1op 92 6 respiratory respiratory JJ cord-019051-gtruu1op 92 7 tract tract NN cord-019051-gtruu1op 92 8 ( ( -LRB- cord-019051-gtruu1op 92 9 LRTI LRTI NNP cord-019051-gtruu1op 92 10 ) ) -RRB- cord-019051-gtruu1op 92 11 was be VBD cord-019051-gtruu1op 92 12 demonstrated demonstrate VBN cord-019051-gtruu1op 92 13 by by IN cord-019051-gtruu1op 92 14 Papadopoulos Papadopoulos NNP cord-019051-gtruu1op 92 15 and and CC cord-019051-gtruu1op 92 16 co co NNS cord-019051-gtruu1op 92 17 - - NNS cord-019051-gtruu1op 92 18 workers worker NNS cord-019051-gtruu1op 92 19 [ [ -LRB- cord-019051-gtruu1op 92 20 23 23 CD cord-019051-gtruu1op 92 21 ] ] -RRB- cord-019051-gtruu1op 92 22 using use VBG cord-019051-gtruu1op 92 23 in in IN cord-019051-gtruu1op 92 24 situ situ NN cord-019051-gtruu1op 92 25 hybridization hybridization NN cord-019051-gtruu1op 92 26 techniques technique NNS cord-019051-gtruu1op 92 27 . . . cord-019051-gtruu1op 93 1 These these DT cord-019051-gtruu1op 93 2 authors author NNS cord-019051-gtruu1op 93 3 demonstrated demonstrate VBD cord-019051-gtruu1op 93 4 RV RV NNP cord-019051-gtruu1op 93 5 infection infection NN cord-019051-gtruu1op 93 6 not not RB cord-019051-gtruu1op 93 7 only only RB cord-019051-gtruu1op 93 8 in in IN cord-019051-gtruu1op 93 9 epithelial epithelial JJ cord-019051-gtruu1op 93 10 cells cell NNS cord-019051-gtruu1op 93 11 but but CC cord-019051-gtruu1op 93 12 also also RB cord-019051-gtruu1op 93 13 in in IN cord-019051-gtruu1op 93 14 underlying underlie VBG cord-019051-gtruu1op 93 15 submucosal submucosal NN cord-019051-gtruu1op 93 16 cells cell NNS cord-019051-gtruu1op 93 17 . . . cord-019051-gtruu1op 94 1 Exacerbation exacerbation NN cord-019051-gtruu1op 94 2 of of IN cord-019051-gtruu1op 94 3 chronic chronic JJ cord-019051-gtruu1op 94 4 bronchitis bronchitis NN cord-019051-gtruu1op 94 5 or or CC cord-019051-gtruu1op 94 6 asthma asthma NN cord-019051-gtruu1op 94 7 may may MD cord-019051-gtruu1op 94 8 be be VB cord-019051-gtruu1op 94 9 a a DT cord-019051-gtruu1op 94 10 consequence consequence NN cord-019051-gtruu1op 94 11 in in IN cord-019051-gtruu1op 94 12 these these DT cord-019051-gtruu1op 94 13 patients patient NNS cord-019051-gtruu1op 94 14 [ [ -LRB- cord-019051-gtruu1op 94 15 24 24 CD cord-019051-gtruu1op 94 16 , , , cord-019051-gtruu1op 94 17 25 25 CD cord-019051-gtruu1op 94 18 ] ] -RRB- cord-019051-gtruu1op 94 19 . . . cord-019051-gtruu1op 95 1 Indeed indeed RB cord-019051-gtruu1op 95 2 , , , cord-019051-gtruu1op 95 3 approximately approximately RB cord-019051-gtruu1op 95 4 80 80 CD cord-019051-gtruu1op 95 5 % % NN cord-019051-gtruu1op 95 6 of of IN cord-019051-gtruu1op 95 7 asthma asthma NN cord-019051-gtruu1op 95 8 exacerbations exacerbation NNS cord-019051-gtruu1op 95 9 in in IN cord-019051-gtruu1op 95 10 children child NNS cord-019051-gtruu1op 95 11 [ [ -LRB- cord-019051-gtruu1op 95 12 26 26 CD cord-019051-gtruu1op 95 13 ] ] -RRB- cord-019051-gtruu1op 95 14 and and CC cord-019051-gtruu1op 95 15 about about RB cord-019051-gtruu1op 95 16 70 70 CD cord-019051-gtruu1op 95 17 % % NN cord-019051-gtruu1op 95 18 in in IN cord-019051-gtruu1op 95 19 adults adult NNS cord-019051-gtruu1op 95 20 [ [ -LRB- cord-019051-gtruu1op 95 21 27 27 CD cord-019051-gtruu1op 95 22 ] ] -RRB- cord-019051-gtruu1op 95 23 are be VBP cord-019051-gtruu1op 95 24 associated associate VBN cord-019051-gtruu1op 95 25 with with IN cord-019051-gtruu1op 95 26 respiratory respiratory JJ cord-019051-gtruu1op 95 27 virus virus NN cord-019051-gtruu1op 95 28 infections infection NNS cord-019051-gtruu1op 95 29 , , , cord-019051-gtruu1op 95 30 and and CC cord-019051-gtruu1op 95 31 the the DT cord-019051-gtruu1op 95 32 vast vast JJ cord-019051-gtruu1op 95 33 majority majority NN cord-019051-gtruu1op 95 34 of of IN cord-019051-gtruu1op 95 35 these these DT cord-019051-gtruu1op 95 36 are be VBP cord-019051-gtruu1op 95 37 RV RV NNP cord-019051-gtruu1op 95 38 infections infection NNS cord-019051-gtruu1op 95 39 [ [ -LRB- cord-019051-gtruu1op 95 40 28 28 CD cord-019051-gtruu1op 95 41 ] ] -RRB- cord-019051-gtruu1op 95 42 . . . cord-019051-gtruu1op 96 1 Examination examination NN cord-019051-gtruu1op 96 2 of of IN cord-019051-gtruu1op 96 3 the the DT cord-019051-gtruu1op 96 4 early early JJ cord-019051-gtruu1op 96 5 innate innate JJ cord-019051-gtruu1op 96 6 immune immune JJ cord-019051-gtruu1op 96 7 responses response NNS cord-019051-gtruu1op 96 8 to to IN cord-019051-gtruu1op 96 9 RV rv NN cord-019051-gtruu1op 96 10 infection infection NN cord-019051-gtruu1op 96 11 in in IN cord-019051-gtruu1op 96 12 asthmatic asthmatic JJ cord-019051-gtruu1op 96 13 bronchial bronchial JJ cord-019051-gtruu1op 96 14 epithelia epithelium NNS cord-019051-gtruu1op 96 15 revealed reveal VBD cord-019051-gtruu1op 96 16 profound profound JJ cord-019051-gtruu1op 96 17 impairment impairment NN cord-019051-gtruu1op 96 18 of of IN cord-019051-gtruu1op 96 19 virus virus NN cord-019051-gtruu1op 96 20 - - HYPH cord-019051-gtruu1op 96 21 induced induce VBN cord-019051-gtruu1op 96 22 interferon interferon NN cord-019051-gtruu1op 96 23 ( ( -LRB- cord-019051-gtruu1op 96 24 IFN)-expression ifn)-expression NN cord-019051-gtruu1op 96 25 leading lead VBG cord-019051-gtruu1op 96 26 to to IN cord-019051-gtruu1op 96 27 impaired impaired JJ cord-019051-gtruu1op 96 28 apoptotic apoptotic JJ cord-019051-gtruu1op 96 29 responses response NNS cord-019051-gtruu1op 96 30 and and CC cord-019051-gtruu1op 96 31 enhanced enhance VBN cord-019051-gtruu1op 96 32 RV rv NN cord-019051-gtruu1op 96 33 replication replication NN cord-019051-gtruu1op 96 34 [ [ -LRB- cord-019051-gtruu1op 96 35 29 29 CD cord-019051-gtruu1op 96 36 ] ] -RRB- cord-019051-gtruu1op 96 37 . . . cord-019051-gtruu1op 97 1 RV rv NN cord-019051-gtruu1op 97 2 infections infection NNS cord-019051-gtruu1op 97 3 lead lead VBP cord-019051-gtruu1op 97 4 to to IN cord-019051-gtruu1op 97 5 the the DT cord-019051-gtruu1op 97 6 production production NN cord-019051-gtruu1op 97 7 of of IN cord-019051-gtruu1op 97 8 type type NN cord-019051-gtruu1op 97 9 - - HYPH cord-019051-gtruu1op 97 10 specific specific JJ cord-019051-gtruu1op 97 11 IgA IgA NNP cord-019051-gtruu1op 97 12 , , , cord-019051-gtruu1op 97 13 IgG IgG NNP cord-019051-gtruu1op 97 14 and and CC cord-019051-gtruu1op 97 15 IgM IgM NNP cord-019051-gtruu1op 97 16 antibodies antibody NNS cord-019051-gtruu1op 97 17 . . . cord-019051-gtruu1op 98 1 However however RB cord-019051-gtruu1op 98 2 , , , cord-019051-gtruu1op 98 3 frequencies frequency NNS cord-019051-gtruu1op 98 4 of of IN cord-019051-gtruu1op 98 5 response response NN cord-019051-gtruu1op 98 6 to to IN cord-019051-gtruu1op 98 7 natural natural JJ cord-019051-gtruu1op 98 8 infection infection NN cord-019051-gtruu1op 98 9 have have VBP cord-019051-gtruu1op 98 10 been be VBN cord-019051-gtruu1op 98 11 reported report VBN cord-019051-gtruu1op 98 12 to to TO cord-019051-gtruu1op 98 13 vary vary VB cord-019051-gtruu1op 98 14 between between IN cord-019051-gtruu1op 98 15 37 37 CD cord-019051-gtruu1op 98 16 % % NN cord-019051-gtruu1op 98 17 and and CC cord-019051-gtruu1op 98 18 92 92 CD cord-019051-gtruu1op 98 19 % % NN cord-019051-gtruu1op 98 20 [ [ -LRB- cord-019051-gtruu1op 98 21 30 30 CD cord-019051-gtruu1op 98 22 ] ] -RRB- cord-019051-gtruu1op 98 23 . . . cord-019051-gtruu1op 99 1 Infected infected JJ cord-019051-gtruu1op 99 2 patients patient NNS cord-019051-gtruu1op 99 3 usually usually RB cord-019051-gtruu1op 99 4 develop develop VBP cord-019051-gtruu1op 99 5 neutralizing neutralize VBG cord-019051-gtruu1op 99 6 antibodies antibody NNS cord-019051-gtruu1op 99 7 to to IN cord-019051-gtruu1op 99 8 the the DT cord-019051-gtruu1op 99 9 infecting infect VBG cord-019051-gtruu1op 99 10 virus virus NN cord-019051-gtruu1op 99 11 within within IN cord-019051-gtruu1op 99 12 1 1 CD cord-019051-gtruu1op 99 13 - - SYM cord-019051-gtruu1op 99 14 3 3 CD cord-019051-gtruu1op 99 15 weeks week NNS cord-019051-gtruu1op 99 16 after after IN cord-019051-gtruu1op 99 17 infection infection NN cord-019051-gtruu1op 99 18 . . . cord-019051-gtruu1op 100 1 IgA IgA NNP cord-019051-gtruu1op 100 2 is be VBZ cord-019051-gtruu1op 100 3 the the DT cord-019051-gtruu1op 100 4 dominant dominant JJ cord-019051-gtruu1op 100 5 immunoglobulin immunoglobulin NN cord-019051-gtruu1op 100 6 in in IN cord-019051-gtruu1op 100 7 nasal nasal NN cord-019051-gtruu1op 100 8 secretions secretion NNS cord-019051-gtruu1op 100 9 , , , cord-019051-gtruu1op 100 10 has have VBZ cord-019051-gtruu1op 100 11 a a DT cord-019051-gtruu1op 100 12 protective protective JJ cord-019051-gtruu1op 100 13 role role NN cord-019051-gtruu1op 100 14 and and CC cord-019051-gtruu1op 100 15 may may MD cord-019051-gtruu1op 100 16 prevent prevent VB cord-019051-gtruu1op 100 17 re re NNS cord-019051-gtruu1op 100 18 - - NNS cord-019051-gtruu1op 100 19 infections infection NNS cord-019051-gtruu1op 100 20 with with IN cord-019051-gtruu1op 100 21 homotypic homotypic JJ cord-019051-gtruu1op 100 22 viruses virus NNS cord-019051-gtruu1op 100 23 or or CC cord-019051-gtruu1op 100 24 reduce reduce VB cord-019051-gtruu1op 100 25 the the DT cord-019051-gtruu1op 100 26 symptoms symptom NNS cord-019051-gtruu1op 100 27 upon upon IN cord-019051-gtruu1op 100 28 reinfection reinfection NN cord-019051-gtruu1op 100 29 . . . cord-019051-gtruu1op 101 1 The the DT cord-019051-gtruu1op 101 2 involvement involvement NN cord-019051-gtruu1op 101 3 in in IN cord-019051-gtruu1op 101 4 the the DT cord-019051-gtruu1op 101 5 viral viral JJ cord-019051-gtruu1op 101 6 clearance clearance NN cord-019051-gtruu1op 101 7 process process NN cord-019051-gtruu1op 101 8 is be VBZ cord-019051-gtruu1op 101 9 less less RBR cord-019051-gtruu1op 101 10 clear clear JJ cord-019051-gtruu1op 101 11 and and CC cord-019051-gtruu1op 101 12 other other JJ cord-019051-gtruu1op 101 13 mechanisms mechanism NNS cord-019051-gtruu1op 101 14 like like IN cord-019051-gtruu1op 101 15 the the DT cord-019051-gtruu1op 101 16 induction induction NN cord-019051-gtruu1op 101 17 of of IN cord-019051-gtruu1op 101 18 an an DT cord-019051-gtruu1op 101 19 innate innate JJ cord-019051-gtruu1op 101 20 immune immune JJ cord-019051-gtruu1op 101 21 response response NN cord-019051-gtruu1op 101 22 are be VBP cord-019051-gtruu1op 101 23 being be VBG cord-019051-gtruu1op 101 24 discussed discuss VBN cord-019051-gtruu1op 101 25 . . . cord-019051-gtruu1op 102 1 Both both DT cord-019051-gtruu1op 102 2 serum serum NN cord-019051-gtruu1op 102 3 and and CC cord-019051-gtruu1op 102 4 secretory secretory JJ cord-019051-gtruu1op 102 5 antibodies antibody NNS cord-019051-gtruu1op 102 6 persist persist VBP cord-019051-gtruu1op 102 7 for for IN cord-019051-gtruu1op 102 8 several several JJ cord-019051-gtruu1op 102 9 years year NNS cord-019051-gtruu1op 102 10 after after IN cord-019051-gtruu1op 102 11 infection infection NN cord-019051-gtruu1op 102 12 . . . cord-019051-gtruu1op 103 1 In in IN cord-019051-gtruu1op 103 2 the the DT cord-019051-gtruu1op 103 3 absence absence NN cord-019051-gtruu1op 103 4 of of IN cord-019051-gtruu1op 103 5 effective effective JJ cord-019051-gtruu1op 103 6 antiviral antiviral JJ cord-019051-gtruu1op 103 7 treatments treatment NNS cord-019051-gtruu1op 103 8 , , , cord-019051-gtruu1op 103 9 the the DT cord-019051-gtruu1op 103 10 diagnosis diagnosis NN cord-019051-gtruu1op 103 11 of of IN cord-019051-gtruu1op 103 12 RV RV NNP cord-019051-gtruu1op 103 13 infection infection NN cord-019051-gtruu1op 103 14 for for IN cord-019051-gtruu1op 103 15 guiding guide VBG cord-019051-gtruu1op 103 16 an an DT cord-019051-gtruu1op 103 17 anti anti JJ cord-019051-gtruu1op 103 18 - - JJ cord-019051-gtruu1op 103 19 RV rv NN cord-019051-gtruu1op 103 20 therapy therapy NN cord-019051-gtruu1op 103 21 is be VBZ cord-019051-gtruu1op 103 22 not not RB cord-019051-gtruu1op 103 23 useful useful JJ cord-019051-gtruu1op 103 24 . . . cord-019051-gtruu1op 104 1 The the DT cord-019051-gtruu1op 104 2 diagnosis diagnosis NN cord-019051-gtruu1op 104 3 of of IN cord-019051-gtruu1op 104 4 RV RV NNP cord-019051-gtruu1op 104 5 infection infection NN cord-019051-gtruu1op 104 6 largely largely RB cord-019051-gtruu1op 104 7 relies rely VBZ cord-019051-gtruu1op 104 8 on on IN cord-019051-gtruu1op 104 9 the the DT cord-019051-gtruu1op 104 10 clinical clinical JJ cord-019051-gtruu1op 104 11 symptoms symptom NNS cord-019051-gtruu1op 104 12 . . . cord-019051-gtruu1op 105 1 Approximately approximately RB cord-019051-gtruu1op 105 2 60 60 CD cord-019051-gtruu1op 105 3 - - SYM cord-019051-gtruu1op 105 4 80 80 CD cord-019051-gtruu1op 105 5 % % NN cord-019051-gtruu1op 105 6 of of IN cord-019051-gtruu1op 105 7 the the DT cord-019051-gtruu1op 105 8 patients patient NNS cord-019051-gtruu1op 105 9 with with IN cord-019051-gtruu1op 105 10 a a DT cord-019051-gtruu1op 105 11 common common JJ cord-019051-gtruu1op 105 12 cold cold JJ cord-019051-gtruu1op 105 13 syndrome syndrome NN cord-019051-gtruu1op 105 14 of of IN cord-019051-gtruu1op 105 15 afebrile afebrile JJ cord-019051-gtruu1op 105 16 prominent prominent JJ cord-019051-gtruu1op 105 17 nasal nasal NN cord-019051-gtruu1op 105 18 symptoms symptom NNS cord-019051-gtruu1op 105 19 but but CC cord-019051-gtruu1op 105 20 minimal minimal JJ cord-019051-gtruu1op 105 21 systemic systemic JJ cord-019051-gtruu1op 105 22 disease disease NN cord-019051-gtruu1op 105 23 that that WDT cord-019051-gtruu1op 105 24 occurs occur VBZ cord-019051-gtruu1op 105 25 between between IN cord-019051-gtruu1op 105 26 August August NNP cord-019051-gtruu1op 105 27 and and CC cord-019051-gtruu1op 105 28 early early JJ cord-019051-gtruu1op 105 29 November November NNP cord-019051-gtruu1op 105 30 have have VBP cord-019051-gtruu1op 105 31 RV rv NN cord-019051-gtruu1op 105 32 infection infection NN cord-019051-gtruu1op 105 33 [ [ -LRB- cord-019051-gtruu1op 105 34 31 31 CD cord-019051-gtruu1op 105 35 ] ] -RRB- cord-019051-gtruu1op 105 36 . . . cord-019051-gtruu1op 106 1 However however RB cord-019051-gtruu1op 106 2 , , , cord-019051-gtruu1op 106 3 the the DT cord-019051-gtruu1op 106 4 general general JJ cord-019051-gtruu1op 106 5 method method NN cord-019051-gtruu1op 106 6 for for IN cord-019051-gtruu1op 106 7 identifying identify VBG cord-019051-gtruu1op 106 8 the the DT cord-019051-gtruu1op 106 9 etiological etiological JJ cord-019051-gtruu1op 106 10 agent agent NN cord-019051-gtruu1op 106 11 is be VBZ cord-019051-gtruu1op 106 12 the the DT cord-019051-gtruu1op 106 13 isolation isolation NN cord-019051-gtruu1op 106 14 and and CC cord-019051-gtruu1op 106 15 propagation propagation NN cord-019051-gtruu1op 106 16 in in IN cord-019051-gtruu1op 106 17 cell cell NN cord-019051-gtruu1op 106 18 culture culture NN cord-019051-gtruu1op 106 19 . . . cord-019051-gtruu1op 107 1 In in IN cord-019051-gtruu1op 107 2 addition addition NN cord-019051-gtruu1op 107 3 , , , cord-019051-gtruu1op 107 4 polymerase polymerase NN cord-019051-gtruu1op 107 5 chain chain NN cord-019051-gtruu1op 107 6 reaction reaction NN cord-019051-gtruu1op 107 7 ( ( -LRB- cord-019051-gtruu1op 107 8 PCR PCR NNP cord-019051-gtruu1op 107 9 ) ) -RRB- cord-019051-gtruu1op 107 10 can can MD cord-019051-gtruu1op 107 11 be be VB cord-019051-gtruu1op 107 12 used use VBN cord-019051-gtruu1op 107 13 for for IN cord-019051-gtruu1op 107 14 rapid rapid JJ cord-019051-gtruu1op 107 15 identification identification NN cord-019051-gtruu1op 107 16 of of IN cord-019051-gtruu1op 107 17 RV RV NNP cord-019051-gtruu1op 107 18 in in IN cord-019051-gtruu1op 107 19 specimens specimen NNS cord-019051-gtruu1op 107 20 . . . cord-019051-gtruu1op 108 1 Point point NN cord-019051-gtruu1op 108 2 - - HYPH cord-019051-gtruu1op 108 3 of of IN cord-019051-gtruu1op 108 4 - - HYPH cord-019051-gtruu1op 108 5 care care NN cord-019051-gtruu1op 108 6 diagnostics diagnostic NNS cord-019051-gtruu1op 108 7 are be VBP cord-019051-gtruu1op 108 8 under under IN cord-019051-gtruu1op 108 9 development development NN cord-019051-gtruu1op 108 10 . . . cord-019051-gtruu1op 109 1 A a DT cord-019051-gtruu1op 109 2 major major JJ cord-019051-gtruu1op 109 3 obstacle obstacle NN cord-019051-gtruu1op 109 4 to to IN cord-019051-gtruu1op 109 5 understanding understand VBG cord-019051-gtruu1op 109 6 disease disease NN cord-019051-gtruu1op 109 7 pathogenesis pathogenesis NN cord-019051-gtruu1op 109 8 has have VBZ cord-019051-gtruu1op 109 9 been be VBN cord-019051-gtruu1op 109 10 the the DT cord-019051-gtruu1op 109 11 lack lack NN cord-019051-gtruu1op 109 12 of of IN cord-019051-gtruu1op 109 13 a a DT cord-019051-gtruu1op 109 14 small small JJ cord-019051-gtruu1op 109 15 - - HYPH cord-019051-gtruu1op 109 16 animal animal NN cord-019051-gtruu1op 109 17 model model NN cord-019051-gtruu1op 109 18 for for IN cord-019051-gtruu1op 109 19 RV rv NN cord-019051-gtruu1op 109 20 infection infection NN cord-019051-gtruu1op 109 21 . . . cord-019051-gtruu1op 110 1 RV RV NNP cord-019051-gtruu1op 110 2 have have VBP cord-019051-gtruu1op 110 3 shown show VBN cord-019051-gtruu1op 110 4 a a DT cord-019051-gtruu1op 110 5 high high JJ cord-019051-gtruu1op 110 6 degree degree NN cord-019051-gtruu1op 110 7 of of IN cord-019051-gtruu1op 110 8 species specie NNS cord-019051-gtruu1op 110 9 specificity specificity NN cord-019051-gtruu1op 110 10 , , , cord-019051-gtruu1op 110 11 limiting limit VBG cord-019051-gtruu1op 110 12 the the DT cord-019051-gtruu1op 110 13 use use NN cord-019051-gtruu1op 110 14 of of IN cord-019051-gtruu1op 110 15 experimental experimental JJ cord-019051-gtruu1op 110 16 animal animal NN cord-019051-gtruu1op 110 17 systems system NNS cord-019051-gtruu1op 110 18 . . . cord-019051-gtruu1op 111 1 Therefore therefore RB cord-019051-gtruu1op 111 2 , , , cord-019051-gtruu1op 111 3 aspects aspect NNS cord-019051-gtruu1op 111 4 of of IN cord-019051-gtruu1op 111 5 pathogenesis pathogenesis NN cord-019051-gtruu1op 111 6 have have VBP cord-019051-gtruu1op 111 7 been be VBN cord-019051-gtruu1op 111 8 studied study VBN cord-019051-gtruu1op 111 9 in in IN cord-019051-gtruu1op 111 10 experimentally experimentally RB cord-019051-gtruu1op 111 11 induced induce VBN cord-019051-gtruu1op 111 12 colds cold NNS cord-019051-gtruu1op 111 13 in in IN cord-019051-gtruu1op 111 14 human human JJ cord-019051-gtruu1op 111 15 volunteers volunteer NNS cord-019051-gtruu1op 111 16 . . . cord-019051-gtruu1op 112 1 Infection infection NN cord-019051-gtruu1op 112 2 of of IN cord-019051-gtruu1op 112 3 rabbits rabbit NNS cord-019051-gtruu1op 112 4 , , , cord-019051-gtruu1op 112 5 guinea guinea NN cord-019051-gtruu1op 112 6 pigs pig NNS cord-019051-gtruu1op 112 7 or or CC cord-019051-gtruu1op 112 8 weanling weanle VBG cord-019051-gtruu1op 112 9 mice mouse NNS cord-019051-gtruu1op 112 10 by by IN cord-019051-gtruu1op 112 11 parenteral parenteral JJ cord-019051-gtruu1op 112 12 routes route NNS cord-019051-gtruu1op 112 13 was be VBD cord-019051-gtruu1op 112 14 not not RB cord-019051-gtruu1op 112 15 successful successful JJ cord-019051-gtruu1op 112 16 with with IN cord-019051-gtruu1op 112 17 certain certain JJ cord-019051-gtruu1op 112 18 strains strain NNS cord-019051-gtruu1op 112 19 of of IN cord-019051-gtruu1op 112 20 the the DT cord-019051-gtruu1op 112 21 virus virus NN cord-019051-gtruu1op 112 22 [ [ -LRB- cord-019051-gtruu1op 112 23 32 32 CD cord-019051-gtruu1op 112 24 ] ] -RRB- cord-019051-gtruu1op 112 25 [ [ -LRB- cord-019051-gtruu1op 112 26 33 33 CD cord-019051-gtruu1op 112 27 ] ] -RRB- cord-019051-gtruu1op 112 28 [ [ -LRB- cord-019051-gtruu1op 112 29 34 34 CD cord-019051-gtruu1op 112 30 ] ] -RRB- cord-019051-gtruu1op 112 31 , , , cord-019051-gtruu1op 112 32 but but CC cord-019051-gtruu1op 112 33 infection infection NN cord-019051-gtruu1op 112 34 of of IN cord-019051-gtruu1op 112 35 mice mouse NNS cord-019051-gtruu1op 112 36 was be VBD cord-019051-gtruu1op 112 37 possible possible JJ cord-019051-gtruu1op 112 38 using use VBG cord-019051-gtruu1op 112 39 a a DT cord-019051-gtruu1op 112 40 tissue tissue NN cord-019051-gtruu1op 112 41 - - HYPH cord-019051-gtruu1op 112 42 culture culture NN cord-019051-gtruu1op 112 43 adapted adapt VBN cord-019051-gtruu1op 112 44 HRV-2 HRV-2 NNP cord-019051-gtruu1op 112 45 [ [ -LRB- cord-019051-gtruu1op 112 46 35 35 CD cord-019051-gtruu1op 112 47 ] ] -RRB- cord-019051-gtruu1op 112 48 . . . cord-019051-gtruu1op 113 1 Chimpanzees chimpanzee NNS cord-019051-gtruu1op 113 2 or or CC cord-019051-gtruu1op 113 3 gibbons gibbon NNS cord-019051-gtruu1op 113 4 has have VBZ cord-019051-gtruu1op 113 5 been be VBN cord-019051-gtruu1op 113 6 experimentally experimentally RB cord-019051-gtruu1op 113 7 infected infect VBN cord-019051-gtruu1op 113 8 using use VBG cord-019051-gtruu1op 113 9 specific specific JJ cord-019051-gtruu1op 113 10 strains strain NNS cord-019051-gtruu1op 113 11 of of IN cord-019051-gtruu1op 113 12 HRV HRV NNP cord-019051-gtruu1op 113 13 [ [ -LRB- cord-019051-gtruu1op 113 14 36 36 CD cord-019051-gtruu1op 113 15 , , , cord-019051-gtruu1op 113 16 37 37 CD cord-019051-gtruu1op 113 17 ] ] -RRB- cord-019051-gtruu1op 113 18 . . . cord-019051-gtruu1op 114 1 Approximately approximately RB cord-019051-gtruu1op 114 2 90 90 CD cord-019051-gtruu1op 114 3 % % NN cord-019051-gtruu1op 114 4 of of IN cord-019051-gtruu1op 114 5 the the DT cord-019051-gtruu1op 114 6 RV RV NNP cord-019051-gtruu1op 114 7 use use VB cord-019051-gtruu1op 114 8 human human JJ cord-019051-gtruu1op 114 9 ICAM-1 icam-1 NN cord-019051-gtruu1op 114 10 as as IN cord-019051-gtruu1op 114 11 their -PRON- PRP$ cord-019051-gtruu1op 114 12 cell cell NN cord-019051-gtruu1op 114 13 receptor receptor NN cord-019051-gtruu1op 114 14 and and CC cord-019051-gtruu1op 114 15 do do VBP cord-019051-gtruu1op 114 16 not not RB cord-019051-gtruu1op 114 17 bind bind VB cord-019051-gtruu1op 114 18 mouse mouse NN cord-019051-gtruu1op 114 19 ICAM-1 ICAM-1 NNP cord-019051-gtruu1op 114 20 ; ; : cord-019051-gtruu1op 114 21 the the DT cord-019051-gtruu1op 114 22 remaining remain VBG cord-019051-gtruu1op 114 23 10 10 CD cord-019051-gtruu1op 114 24 % % NN cord-019051-gtruu1op 114 25 use use NN cord-019051-gtruu1op 114 26 a a DT cord-019051-gtruu1op 114 27 member member NN cord-019051-gtruu1op 114 28 of of IN cord-019051-gtruu1op 114 29 the the DT cord-019051-gtruu1op 114 30 low low JJ cord-019051-gtruu1op 114 31 - - HYPH cord-019051-gtruu1op 114 32 density density NN cord-019051-gtruu1op 114 33 lipoprotein lipoprotein NN cord-019051-gtruu1op 114 34 receptor receptor NN cord-019051-gtruu1op 114 35 family family NN cord-019051-gtruu1op 114 36 and and CC cord-019051-gtruu1op 114 37 can can MD cord-019051-gtruu1op 114 38 bind bind VB cord-019051-gtruu1op 114 39 the the DT cord-019051-gtruu1op 114 40 mouse mouse NN cord-019051-gtruu1op 114 41 counterpart counterpart NN cord-019051-gtruu1op 114 42 . . . cord-019051-gtruu1op 115 1 Recently recently RB cord-019051-gtruu1op 115 2 , , , cord-019051-gtruu1op 115 3 three three CD cord-019051-gtruu1op 115 4 novel novel JJ cord-019051-gtruu1op 115 5 mouse mouse NN cord-019051-gtruu1op 115 6 models model NNS cord-019051-gtruu1op 115 7 of of IN cord-019051-gtruu1op 115 8 RV RV NNP cord-019051-gtruu1op 115 9 infection infection NN cord-019051-gtruu1op 115 10 : : : cord-019051-gtruu1op 115 11 minor minor JJ cord-019051-gtruu1op 115 12 - - HYPH cord-019051-gtruu1op 115 13 group group NN cord-019051-gtruu1op 115 14 RV rv NN cord-019051-gtruu1op 115 15 infection infection NN cord-019051-gtruu1op 115 16 of of IN cord-019051-gtruu1op 115 17 BALB BALB NNP cord-019051-gtruu1op 115 18 / / SYM cord-019051-gtruu1op 115 19 c c NN cord-019051-gtruu1op 115 20 mice mouse NNS cord-019051-gtruu1op 115 21 , , , cord-019051-gtruu1op 115 22 major major JJ cord-019051-gtruu1op 115 23 - - HYPH cord-019051-gtruu1op 115 24 group group NN cord-019051-gtruu1op 115 25 RV rv NN cord-019051-gtruu1op 115 26 infection infection NN cord-019051-gtruu1op 115 27 of of IN cord-019051-gtruu1op 115 28 transgenic transgenic JJ cord-019051-gtruu1op 115 29 BALB BALB NNP cord-019051-gtruu1op 115 30 / / SYM cord-019051-gtruu1op 115 31 c c NN cord-019051-gtruu1op 115 32 mice mouse NNS cord-019051-gtruu1op 115 33 expressing express VBG cord-019051-gtruu1op 115 34 a a DT cord-019051-gtruu1op 115 35 mouse mouse NN cord-019051-gtruu1op 115 36 - - HYPH cord-019051-gtruu1op 115 37 human human JJ cord-019051-gtruu1op 115 38 ICAM-1 icam-1 NN cord-019051-gtruu1op 115 39 chimera chimera NN cord-019051-gtruu1op 115 40 and and CC cord-019051-gtruu1op 115 41 RV rv NN cord-019051-gtruu1op 115 42 - - HYPH cord-019051-gtruu1op 115 43 induced induce VBN cord-019051-gtruu1op 115 44 exacerbation exacerbation NN cord-019051-gtruu1op 115 45 of of IN cord-019051-gtruu1op 115 46 allergic allergic JJ cord-019051-gtruu1op 115 47 airway airway NN cord-019051-gtruu1op 115 48 inflammation inflammation NN cord-019051-gtruu1op 115 49 were be VBD cord-019051-gtruu1op 115 50 described describe VBN cord-019051-gtruu1op 115 51 by by IN cord-019051-gtruu1op 115 52 Bartlett Bartlett NNP cord-019051-gtruu1op 115 53 et et NNP cord-019051-gtruu1op 115 54 al al NNP cord-019051-gtruu1op 115 55 . . . cord-019051-gtruu1op 116 1 [ [ -LRB- cord-019051-gtruu1op 116 2 38 38 CD cord-019051-gtruu1op 116 3 ] ] -RRB- cord-019051-gtruu1op 116 4 . . . cord-019051-gtruu1op 117 1 These these DT cord-019051-gtruu1op 117 2 models model NNS cord-019051-gtruu1op 117 3 have have VBP cord-019051-gtruu1op 117 4 features feature NNS cord-019051-gtruu1op 117 5 similar similar JJ cord-019051-gtruu1op 117 6 to to IN cord-019051-gtruu1op 117 7 those those DT cord-019051-gtruu1op 117 8 observed observe VBN cord-019051-gtruu1op 117 9 in in IN cord-019051-gtruu1op 117 10 RV RV NNP cord-019051-gtruu1op 117 11 infection infection NN cord-019051-gtruu1op 117 12 in in IN cord-019051-gtruu1op 117 13 humans human NNS cord-019051-gtruu1op 117 14 , , , cord-019051-gtruu1op 117 15 including include VBG cord-019051-gtruu1op 117 16 augmentation augmentation NN cord-019051-gtruu1op 117 17 of of IN cord-019051-gtruu1op 117 18 allergic allergic JJ cord-019051-gtruu1op 117 19 airway airway NN cord-019051-gtruu1op 117 20 inflammation inflammation NN cord-019051-gtruu1op 117 21 , , , cord-019051-gtruu1op 117 22 and and CC cord-019051-gtruu1op 117 23 may may MD cord-019051-gtruu1op 117 24 be be VB cord-019051-gtruu1op 117 25 useful useful JJ cord-019051-gtruu1op 117 26 in in IN cord-019051-gtruu1op 117 27 the the DT cord-019051-gtruu1op 117 28 development development NN cord-019051-gtruu1op 117 29 of of IN cord-019051-gtruu1op 117 30 future future JJ cord-019051-gtruu1op 117 31 therapies therapy NNS cord-019051-gtruu1op 117 32 for for IN cord-019051-gtruu1op 117 33 colds cold NNS cord-019051-gtruu1op 117 34 and and CC cord-019051-gtruu1op 117 35 asthma asthma NN cord-019051-gtruu1op 117 36 exacerbations exacerbation NNS cord-019051-gtruu1op 117 37 . . . cord-019051-gtruu1op 118 1 Association association NN cord-019051-gtruu1op 118 2 between between IN cord-019051-gtruu1op 118 3 common common JJ cord-019051-gtruu1op 118 4 cold cold JJ cord-019051-gtruu1op 118 5 symptoms symptom NNS cord-019051-gtruu1op 118 6 and and CC cord-019051-gtruu1op 118 7 inflammatory inflammatory JJ cord-019051-gtruu1op 118 8 mediators mediator NNS cord-019051-gtruu1op 118 9 is be VBZ cord-019051-gtruu1op 118 10 an an DT cord-019051-gtruu1op 118 11 important important JJ cord-019051-gtruu1op 118 12 aspect aspect NN cord-019051-gtruu1op 118 13 of of IN cord-019051-gtruu1op 118 14 understanding understand VBG cord-019051-gtruu1op 118 15 common common JJ cord-019051-gtruu1op 118 16 cold cold NN cord-019051-gtruu1op 118 17 and and CC cord-019051-gtruu1op 118 18 RV RV NNP cord-019051-gtruu1op 118 19 infection infection NN cord-019051-gtruu1op 118 20 . . . cord-019051-gtruu1op 119 1 Although although IN cord-019051-gtruu1op 119 2 this this DT cord-019051-gtruu1op 119 3 association association NN cord-019051-gtruu1op 119 4 seems seem VBZ cord-019051-gtruu1op 119 5 obvious obvious JJ cord-019051-gtruu1op 119 6 , , , cord-019051-gtruu1op 119 7 the the DT cord-019051-gtruu1op 119 8 exact exact JJ cord-019051-gtruu1op 119 9 mechanisms mechanism NNS cord-019051-gtruu1op 119 10 are be VBP cord-019051-gtruu1op 119 11 less less RBR cord-019051-gtruu1op 119 12 clear clear JJ cord-019051-gtruu1op 119 13 and and CC cord-019051-gtruu1op 119 14 one one PRP cord-019051-gtruu1op 119 15 might may MD cord-019051-gtruu1op 119 16 expect expect VB cord-019051-gtruu1op 119 17 a a DT cord-019051-gtruu1op 119 18 better well JJR cord-019051-gtruu1op 119 19 understanding understanding NN cord-019051-gtruu1op 119 20 of of IN cord-019051-gtruu1op 119 21 the the DT cord-019051-gtruu1op 119 22 detailed detailed JJ cord-019051-gtruu1op 119 23 mechanism(s mechanism(s NN cord-019051-gtruu1op 119 24 ) ) -RRB- cord-019051-gtruu1op 119 25 once once IN cord-019051-gtruu1op 119 26 inhibitors inhibitor NNS cord-019051-gtruu1op 119 27 of of IN cord-019051-gtruu1op 119 28 viral viral JJ cord-019051-gtruu1op 119 29 replication replication NN cord-019051-gtruu1op 119 30 are be VBP cord-019051-gtruu1op 119 31 available available JJ cord-019051-gtruu1op 119 32 for for IN cord-019051-gtruu1op 119 33 studies study NNS cord-019051-gtruu1op 119 34 in in IN cord-019051-gtruu1op 119 35 humans human NNS cord-019051-gtruu1op 119 36 . . . cord-019051-gtruu1op 120 1 In in IN cord-019051-gtruu1op 120 2 addition addition NN cord-019051-gtruu1op 120 3 , , , cord-019051-gtruu1op 120 4 the the DT cord-019051-gtruu1op 120 5 new new JJ cord-019051-gtruu1op 120 6 animal animal NN cord-019051-gtruu1op 120 7 models model NNS cord-019051-gtruu1op 120 8 developed develop VBN cord-019051-gtruu1op 120 9 by by IN cord-019051-gtruu1op 120 10 Bartlett Bartlett NNP cord-019051-gtruu1op 120 11 et et NNP cord-019051-gtruu1op 120 12 al al NNP cord-019051-gtruu1op 120 13 . . . cord-019051-gtruu1op 121 1 [ [ -LRB- cord-019051-gtruu1op 121 2 38 38 CD cord-019051-gtruu1op 121 3 ] ] -RRB- cord-019051-gtruu1op 121 4 can can MD cord-019051-gtruu1op 121 5 be be VB cord-019051-gtruu1op 121 6 expected expect VBN cord-019051-gtruu1op 121 7 to to TO cord-019051-gtruu1op 121 8 support support VB cord-019051-gtruu1op 121 9 efforts effort NNS cord-019051-gtruu1op 121 10 to to TO cord-019051-gtruu1op 121 11 study study VB cord-019051-gtruu1op 121 12 pathogenesis pathogenesis NN cord-019051-gtruu1op 121 13 of of IN cord-019051-gtruu1op 121 14 RV RV NNP cord-019051-gtruu1op 121 15 infection infection NN cord-019051-gtruu1op 121 16 in in IN cord-019051-gtruu1op 121 17 vivo vivo NN cord-019051-gtruu1op 121 18 in in IN cord-019051-gtruu1op 121 19 greater great JJR cord-019051-gtruu1op 121 20 detail detail NN cord-019051-gtruu1op 121 21 . . . cord-019051-gtruu1op 122 1 Human human JJ cord-019051-gtruu1op 122 2 respiratory respiratory JJ cord-019051-gtruu1op 122 3 syncytial syncytial JJ cord-019051-gtruu1op 122 4 virus virus NN cord-019051-gtruu1op 122 5 ( ( -LRB- cord-019051-gtruu1op 122 6 RSV RSV NNP cord-019051-gtruu1op 122 7 ) ) -RRB- cord-019051-gtruu1op 122 8 was be VBD cord-019051-gtruu1op 122 9 first first RB cord-019051-gtruu1op 122 10 isolated isolate VBN cord-019051-gtruu1op 122 11 from from IN cord-019051-gtruu1op 122 12 a a DT cord-019051-gtruu1op 122 13 laboratory laboratory NN cord-019051-gtruu1op 122 14 chimpanzee chimpanzee NN cord-019051-gtruu1op 122 15 with with IN cord-019051-gtruu1op 122 16 upper upper JJ cord-019051-gtruu1op 122 17 respiratory respiratory JJ cord-019051-gtruu1op 122 18 tract tract NN cord-019051-gtruu1op 122 19 infection infection NN cord-019051-gtruu1op 122 20 ( ( -LRB- cord-019051-gtruu1op 122 21 URTI URTI NNP cord-019051-gtruu1op 122 22 ) ) -RRB- cord-019051-gtruu1op 122 23 in in IN cord-019051-gtruu1op 122 24 1956 1956 CD cord-019051-gtruu1op 122 25 [ [ -LRB- cord-019051-gtruu1op 122 26 39 39 CD cord-019051-gtruu1op 122 27 ] ] -RRB- cord-019051-gtruu1op 122 28 . . . cord-019051-gtruu1op 123 1 RSV RSV NNP cord-019051-gtruu1op 123 2 is be VBZ cord-019051-gtruu1op 123 3 today today NN cord-019051-gtruu1op 123 4 recognized recognize VBN cord-019051-gtruu1op 123 5 as as IN cord-019051-gtruu1op 123 6 the the DT cord-019051-gtruu1op 123 7 leading lead VBG cord-019051-gtruu1op 123 8 viral viral JJ cord-019051-gtruu1op 123 9 agent agent NN cord-019051-gtruu1op 123 10 in in IN cord-019051-gtruu1op 123 11 upper upper JJ cord-019051-gtruu1op 123 12 respiratory respiratory JJ cord-019051-gtruu1op 123 13 tract tract NN cord-019051-gtruu1op 123 14 disease disease NN cord-019051-gtruu1op 123 15 in in IN cord-019051-gtruu1op 123 16 infancy infancy NN cord-019051-gtruu1op 123 17 and and CC cord-019051-gtruu1op 123 18 childhood childhood NN cord-019051-gtruu1op 123 19 . . . cord-019051-gtruu1op 124 1 The the DT cord-019051-gtruu1op 124 2 spectrum spectrum NN cord-019051-gtruu1op 124 3 of of IN cord-019051-gtruu1op 124 4 RSV RSV NNP cord-019051-gtruu1op 124 5 - - HYPH cord-019051-gtruu1op 124 6 caused cause VBN cord-019051-gtruu1op 124 7 diseases disease NNS cord-019051-gtruu1op 124 8 includes include VBZ cord-019051-gtruu1op 124 9 rhinitis rhinitis NN cord-019051-gtruu1op 124 10 , , , cord-019051-gtruu1op 124 11 otitis otitis NN cord-019051-gtruu1op 124 12 media medium NNS cord-019051-gtruu1op 124 13 , , , cord-019051-gtruu1op 124 14 pneumonia pneumonia NN cord-019051-gtruu1op 124 15 and and CC cord-019051-gtruu1op 124 16 bronchiolitis bronchiolitis NN cord-019051-gtruu1op 124 17 . . . cord-019051-gtruu1op 125 1 The the DT cord-019051-gtruu1op 125 2 latter latter JJ cord-019051-gtruu1op 125 3 two two CD cord-019051-gtruu1op 125 4 diseases disease NNS cord-019051-gtruu1op 125 5 can can MD cord-019051-gtruu1op 125 6 be be VB cord-019051-gtruu1op 125 7 associated associate VBN cord-019051-gtruu1op 125 8 with with IN cord-019051-gtruu1op 125 9 a a DT cord-019051-gtruu1op 125 10 substantial substantial JJ cord-019051-gtruu1op 125 11 morbidity morbidity NN cord-019051-gtruu1op 125 12 and and CC cord-019051-gtruu1op 125 13 mortality mortality NN cord-019051-gtruu1op 125 14 . . . cord-019051-gtruu1op 126 1 In in IN cord-019051-gtruu1op 126 2 addition addition NN cord-019051-gtruu1op 126 3 , , , cord-019051-gtruu1op 126 4 there there EX cord-019051-gtruu1op 126 5 is be VBZ cord-019051-gtruu1op 126 6 growing grow VBG cord-019051-gtruu1op 126 7 recognition recognition NN cord-019051-gtruu1op 126 8 for for IN cord-019051-gtruu1op 126 9 its -PRON- PRP$ cord-019051-gtruu1op 126 10 importance importance NN cord-019051-gtruu1op 126 11 as as IN cord-019051-gtruu1op 126 12 a a DT cord-019051-gtruu1op 126 13 causative causative JJ cord-019051-gtruu1op 126 14 agent agent NN cord-019051-gtruu1op 126 15 for for IN cord-019051-gtruu1op 126 16 diseases disease NNS cord-019051-gtruu1op 126 17 in in IN cord-019051-gtruu1op 126 18 elderly elderly JJ cord-019051-gtruu1op 126 19 and and CC cord-019051-gtruu1op 126 20 immunocompromised immunocompromised JJ cord-019051-gtruu1op 126 21 patients patient NNS cord-019051-gtruu1op 126 22 [ [ -LRB- cord-019051-gtruu1op 126 23 40 40 CD cord-019051-gtruu1op 126 24 ] ] -RRB- cord-019051-gtruu1op 126 25 . . . cord-019051-gtruu1op 127 1 The the DT cord-019051-gtruu1op 127 2 World World NNP cord-019051-gtruu1op 127 3 Health Health NNP cord-019051-gtruu1op 127 4 Organization Organization NNP cord-019051-gtruu1op 127 5 estimates estimate VBZ cord-019051-gtruu1op 127 6 that that IN cord-019051-gtruu1op 127 7 RSV RSV NNP cord-019051-gtruu1op 127 8 causes cause VBZ cord-019051-gtruu1op 127 9 64 64 CD cord-019051-gtruu1op 127 10 million million CD cord-019051-gtruu1op 127 11 infections infection NNS cord-019051-gtruu1op 127 12 and and CC cord-019051-gtruu1op 127 13 160 160 CD cord-019051-gtruu1op 127 14 000 000 CD cord-019051-gtruu1op 127 15 deaths death NNS cord-019051-gtruu1op 127 16 annually annually RB cord-019051-gtruu1op 127 17 [ [ -LRB- cord-019051-gtruu1op 127 18 41 41 CD cord-019051-gtruu1op 127 19 ] ] -RRB- cord-019051-gtruu1op 127 20 . . . cord-019051-gtruu1op 128 1 A a DT cord-019051-gtruu1op 128 2 bovine bovine JJ cord-019051-gtruu1op 128 3 RSV rsv NN cord-019051-gtruu1op 128 4 ( ( -LRB- cord-019051-gtruu1op 128 5 BRSV BRSV NNP cord-019051-gtruu1op 128 6 ) ) -RRB- cord-019051-gtruu1op 128 7 has have VBZ cord-019051-gtruu1op 128 8 been be VBN cord-019051-gtruu1op 128 9 described describe VBN cord-019051-gtruu1op 128 10 causing cause VBG cord-019051-gtruu1op 128 11 economically economically RB cord-019051-gtruu1op 128 12 important important JJ cord-019051-gtruu1op 128 13 respiratory respiratory JJ cord-019051-gtruu1op 128 14 diseases disease NNS cord-019051-gtruu1op 128 15 in in IN cord-019051-gtruu1op 128 16 cattle cattle NNS cord-019051-gtruu1op 128 17 [ [ -LRB- cord-019051-gtruu1op 128 18 42 42 CD cord-019051-gtruu1op 128 19 ] ] -RRB- cord-019051-gtruu1op 128 20 . . . cord-019051-gtruu1op 129 1 Another another DT cord-019051-gtruu1op 129 2 animal animal NN cord-019051-gtruu1op 129 3 RSV RSV NNP cord-019051-gtruu1op 129 4 is be VBZ cord-019051-gtruu1op 129 5 the the DT cord-019051-gtruu1op 129 6 pneumonia pneumonia NN cord-019051-gtruu1op 129 7 virus virus NN cord-019051-gtruu1op 129 8 of of IN cord-019051-gtruu1op 129 9 mice mouse NNS cord-019051-gtruu1op 129 10 ( ( -LRB- cord-019051-gtruu1op 129 11 PVM pvm NN cord-019051-gtruu1op 129 12 ) ) -RRB- cord-019051-gtruu1op 130 1 [ [ -LRB- cord-019051-gtruu1op 130 2 43 43 CD cord-019051-gtruu1op 130 3 ] ] -RRB- cord-019051-gtruu1op 130 4 , , , cord-019051-gtruu1op 130 5 suggesting suggest VBG cord-019051-gtruu1op 130 6 that that IN cord-019051-gtruu1op 130 7 there there EX cord-019051-gtruu1op 130 8 was be VBD cord-019051-gtruu1op 130 9 an an DT cord-019051-gtruu1op 130 10 interspecies interspecies NN cord-019051-gtruu1op 130 11 spread spread VBN cord-019051-gtruu1op 130 12 in in IN cord-019051-gtruu1op 130 13 the the DT cord-019051-gtruu1op 130 14 evolution evolution NN cord-019051-gtruu1op 130 15 of of IN cord-019051-gtruu1op 130 16 these these DT cord-019051-gtruu1op 130 17 viruses virus NNS cord-019051-gtruu1op 130 18 . . . cord-019051-gtruu1op 131 1 However however RB cord-019051-gtruu1op 131 2 , , , cord-019051-gtruu1op 131 3 an an DT cord-019051-gtruu1op 131 4 animal animal NN cord-019051-gtruu1op 131 5 reservoir reservoir NN cord-019051-gtruu1op 131 6 for for IN cord-019051-gtruu1op 131 7 human human JJ cord-019051-gtruu1op 131 8 RSV RSV NNP cord-019051-gtruu1op 131 9 has have VBZ cord-019051-gtruu1op 131 10 not not RB cord-019051-gtruu1op 131 11 been be VBN cord-019051-gtruu1op 131 12 described describe VBN cord-019051-gtruu1op 131 13 so so RB cord-019051-gtruu1op 131 14 far far RB cord-019051-gtruu1op 131 15 [ [ -LRB- cord-019051-gtruu1op 131 16 44 44 CD cord-019051-gtruu1op 131 17 ] ] -RRB- cord-019051-gtruu1op 131 18 . . . cord-019051-gtruu1op 132 1 Despite despite IN cord-019051-gtruu1op 132 2 the the DT cord-019051-gtruu1op 132 3 importance importance NN cord-019051-gtruu1op 132 4 of of IN cord-019051-gtruu1op 132 5 RSV RSV NNP cord-019051-gtruu1op 132 6 as as IN cord-019051-gtruu1op 132 7 a a DT cord-019051-gtruu1op 132 8 leading leading JJ cord-019051-gtruu1op 132 9 cause cause NN cord-019051-gtruu1op 132 10 for for IN cord-019051-gtruu1op 132 11 respiratory respiratory JJ cord-019051-gtruu1op 132 12 diseases disease NNS cord-019051-gtruu1op 132 13 , , , cord-019051-gtruu1op 132 14 the the DT cord-019051-gtruu1op 132 15 pathogenesis pathogenesis NN cord-019051-gtruu1op 132 16 of of IN cord-019051-gtruu1op 132 17 RSV RSV NNP cord-019051-gtruu1op 132 18 infection infection NN cord-019051-gtruu1op 132 19 is be VBZ cord-019051-gtruu1op 132 20 not not RB cord-019051-gtruu1op 132 21 fully fully RB cord-019051-gtruu1op 132 22 understood understand VBN cord-019051-gtruu1op 132 23 and and CC cord-019051-gtruu1op 132 24 efficacious efficacious JJ cord-019051-gtruu1op 132 25 vaccines vaccine NNS cord-019051-gtruu1op 132 26 are be VBP cord-019051-gtruu1op 132 27 not not RB cord-019051-gtruu1op 132 28 available available JJ cord-019051-gtruu1op 132 29 . . . cord-019051-gtruu1op 133 1 RSV RSV NNP cord-019051-gtruu1op 133 2 is be VBZ cord-019051-gtruu1op 133 3 a a DT cord-019051-gtruu1op 133 4 member member NN cord-019051-gtruu1op 133 5 of of IN cord-019051-gtruu1op 133 6 the the DT cord-019051-gtruu1op 133 7 order order NN cord-019051-gtruu1op 133 8 Mononegavirales Mononegavirales NNP cord-019051-gtruu1op 133 9 , , , cord-019051-gtruu1op 133 10 which which WDT cord-019051-gtruu1op 133 11 includes include VBZ cord-019051-gtruu1op 133 12 several several JJ cord-019051-gtruu1op 133 13 non non JJ cord-019051-gtruu1op 133 14 - - JJ cord-019051-gtruu1op 133 15 segmented segmented JJ cord-019051-gtruu1op 133 16 negative negative JJ cord-019051-gtruu1op 133 17 - - HYPH cord-019051-gtruu1op 133 18 strand strand NN cord-019051-gtruu1op 133 19 RNA RNA NNP cord-019051-gtruu1op 133 20 viruses virus NNS cord-019051-gtruu1op 133 21 . . . cord-019051-gtruu1op 134 1 RSV RSV NNP cord-019051-gtruu1op 134 2 is be VBZ cord-019051-gtruu1op 134 3 a a DT cord-019051-gtruu1op 134 4 member member NN cord-019051-gtruu1op 134 5 of of IN cord-019051-gtruu1op 134 6 the the DT cord-019051-gtruu1op 134 7 family family NN cord-019051-gtruu1op 134 8 of of IN cord-019051-gtruu1op 134 9 Paramyxoviridae Paramyxoviridae NNP cord-019051-gtruu1op 134 10 , , , cord-019051-gtruu1op 134 11 subfamily subfamily NN cord-019051-gtruu1op 134 12 Pneumovirinae Pneumovirinae NNP cord-019051-gtruu1op 134 13 and and CC cord-019051-gtruu1op 134 14 represents represent VBZ cord-019051-gtruu1op 134 15 the the DT cord-019051-gtruu1op 134 16 type type NN cord-019051-gtruu1op 134 17 species specie NNS cord-019051-gtruu1op 134 18 for for IN cord-019051-gtruu1op 134 19 the the DT cord-019051-gtruu1op 134 20 genus genus NN cord-019051-gtruu1op 135 1 Pneumovirus Pneumovirus NNP cord-019051-gtruu1op 135 2 [ [ -LRB- cord-019051-gtruu1op 135 3 43 43 CD cord-019051-gtruu1op 135 4 ] ] -RRB- cord-019051-gtruu1op 135 5 . . . cord-019051-gtruu1op 136 1 RSV RSV NNP cord-019051-gtruu1op 136 2 virions virion NNS cord-019051-gtruu1op 136 3 consist consist VBP cord-019051-gtruu1op 136 4 of of IN cord-019051-gtruu1op 136 5 an an DT cord-019051-gtruu1op 136 6 envelope envelope NN cord-019051-gtruu1op 136 7 and and CC cord-019051-gtruu1op 136 8 a a DT cord-019051-gtruu1op 136 9 nucleocapsid nucleocapsid NN cord-019051-gtruu1op 136 10 . . . cord-019051-gtruu1op 137 1 The the DT cord-019051-gtruu1op 137 2 viral viral JJ cord-019051-gtruu1op 137 3 gene gene NN cord-019051-gtruu1op 137 4 expression expression NN cord-019051-gtruu1op 137 5 and and CC cord-019051-gtruu1op 137 6 nucleic nucleic JJ cord-019051-gtruu1op 137 7 acid acid NN cord-019051-gtruu1op 137 8 replication replication NN cord-019051-gtruu1op 137 9 occur occur VBP cord-019051-gtruu1op 137 10 in in IN cord-019051-gtruu1op 137 11 the the DT cord-019051-gtruu1op 137 12 cytoplasm cytoplasm NN cord-019051-gtruu1op 137 13 . . . cord-019051-gtruu1op 138 1 The the DT cord-019051-gtruu1op 138 2 envelope envelope NN cord-019051-gtruu1op 138 3 is be VBZ cord-019051-gtruu1op 138 4 acquired acquire VBN cord-019051-gtruu1op 138 5 by by IN cord-019051-gtruu1op 138 6 cell cell NN cord-019051-gtruu1op 138 7 budding budding NN cord-019051-gtruu1op 138 8 . . . cord-019051-gtruu1op 139 1 Virions virion NNS cord-019051-gtruu1op 139 2 are be VBP cord-019051-gtruu1op 139 3 spherical spherical JJ cord-019051-gtruu1op 139 4 to to IN cord-019051-gtruu1op 139 5 pleomorphic pleomorphic JJ cord-019051-gtruu1op 139 6 ; ; , cord-019051-gtruu1op 139 7 filamentous filamentous JJ cord-019051-gtruu1op 139 8 and and CC cord-019051-gtruu1op 139 9 other other JJ cord-019051-gtruu1op 139 10 forms form NNS cord-019051-gtruu1op 139 11 are be VBP cord-019051-gtruu1op 139 12 common common JJ cord-019051-gtruu1op 139 13 . . . cord-019051-gtruu1op 140 1 They -PRON- PRP cord-019051-gtruu1op 140 2 measure measure VBP cord-019051-gtruu1op 140 3 150 150 CD cord-019051-gtruu1op 140 4 - - SYM cord-019051-gtruu1op 140 5 300 300 CD cord-019051-gtruu1op 140 6 nm nm NN cord-019051-gtruu1op 140 7 in in IN cord-019051-gtruu1op 140 8 diameter diameter NN cord-019051-gtruu1op 140 9 and and CC cord-019051-gtruu1op 140 10 up up IN cord-019051-gtruu1op 140 11 to to TO cord-019051-gtruu1op 140 12 1000 1000 CD cord-019051-gtruu1op 140 13 - - SYM cord-019051-gtruu1op 140 14 10 10 CD cord-019051-gtruu1op 140 15 000 000 CD cord-019051-gtruu1op 140 16 nm nm NN cord-019051-gtruu1op 140 17 in in IN cord-019051-gtruu1op 140 18 length length NN cord-019051-gtruu1op 140 19 [ [ -LRB- cord-019051-gtruu1op 140 20 45 45 CD cord-019051-gtruu1op 140 21 ] ] -RRB- cord-019051-gtruu1op 140 22 . . . cord-019051-gtruu1op 141 1 The the DT cord-019051-gtruu1op 141 2 surface surface NN cord-019051-gtruu1op 141 3 of of IN cord-019051-gtruu1op 141 4 the the DT cord-019051-gtruu1op 141 5 virion virion NN cord-019051-gtruu1op 141 6 is be VBZ cord-019051-gtruu1op 141 7 covered cover VBN cord-019051-gtruu1op 141 8 by by IN cord-019051-gtruu1op 141 9 projections projection NNS cord-019051-gtruu1op 141 10 ( ( -LRB- cord-019051-gtruu1op 141 11 spikes spike NNS cord-019051-gtruu1op 141 12 ) ) -RRB- cord-019051-gtruu1op 141 13 formed form VBN cord-019051-gtruu1op 141 14 by by IN cord-019051-gtruu1op 141 15 fusion fusion NN cord-019051-gtruu1op 141 16 ( ( -LRB- cord-019051-gtruu1op 141 17 F F NNP cord-019051-gtruu1op 141 18 ) ) -RRB- cord-019051-gtruu1op 141 19 glycoproteins glycoprotein NNS cord-019051-gtruu1op 141 20 . . . cord-019051-gtruu1op 142 1 The the DT cord-019051-gtruu1op 142 2 spikes spike NNS cord-019051-gtruu1op 142 3 are be VBP cord-019051-gtruu1op 142 4 11 11 CD cord-019051-gtruu1op 142 5 - - SYM cord-019051-gtruu1op 142 6 20 20 CD cord-019051-gtruu1op 142 7 nm nm NN cord-019051-gtruu1op 142 8 long long RB cord-019051-gtruu1op 142 9 and and CC cord-019051-gtruu1op 142 10 are be VBP cord-019051-gtruu1op 142 11 spaced space VBN cord-019051-gtruu1op 142 12 6 6 CD cord-019051-gtruu1op 142 13 - - SYM cord-019051-gtruu1op 142 14 10 10 CD cord-019051-gtruu1op 142 15 nm nm NN cord-019051-gtruu1op 142 16 apart apart RB cord-019051-gtruu1op 142 17 ; ; : cord-019051-gtruu1op 142 18 they -PRON- PRP cord-019051-gtruu1op 142 19 mediate mediate VBP cord-019051-gtruu1op 142 20 attachment attachment NN cord-019051-gtruu1op 142 21 and and CC cord-019051-gtruu1op 142 22 penetration penetration NN cord-019051-gtruu1op 142 23 . . . cord-019051-gtruu1op 143 1 The the DT cord-019051-gtruu1op 143 2 helical helical JJ cord-019051-gtruu1op 143 3 nucleocapsid nucleocapsid NN cord-019051-gtruu1op 143 4 is be VBZ cord-019051-gtruu1op 143 5 filamentous filamentous JJ cord-019051-gtruu1op 143 6 with with IN cord-019051-gtruu1op 143 7 a a DT cord-019051-gtruu1op 143 8 length length NN cord-019051-gtruu1op 143 9 of of IN cord-019051-gtruu1op 143 10 600 600 CD cord-019051-gtruu1op 143 11 - - HYPH cord-019051-gtruu1op 143 12 800(1000 800(1000 CD cord-019051-gtruu1op 143 13 ) ) -RRB- cord-019051-gtruu1op 143 14 nm nm NN cord-019051-gtruu1op 143 15 and and CC cord-019051-gtruu1op 143 16 a a DT cord-019051-gtruu1op 143 17 width width NN cord-019051-gtruu1op 143 18 of of IN cord-019051-gtruu1op 143 19 12 12 CD cord-019051-gtruu1op 143 20 - - SYM cord-019051-gtruu1op 143 21 15 15 CD cord-019051-gtruu1op 143 22 nm nm CD cord-019051-gtruu1op 143 23 [ [ -LRB- cord-019051-gtruu1op 143 24 40 40 CD cord-019051-gtruu1op 143 25 ] ] -RRB- cord-019051-gtruu1op 143 26 . . . cord-019051-gtruu1op 144 1 The the DT cord-019051-gtruu1op 144 2 nucleocapsid nucleocapsid NN cord-019051-gtruu1op 144 3 does do VBZ cord-019051-gtruu1op 144 4 not not RB cord-019051-gtruu1op 144 5 enter enter VB cord-019051-gtruu1op 144 6 the the DT cord-019051-gtruu1op 144 7 cells cell NNS cord-019051-gtruu1op 144 8 by by IN cord-019051-gtruu1op 144 9 surface surface NN cord-019051-gtruu1op 144 10 fusion fusion NN cord-019051-gtruu1op 144 11 typical typical JJ cord-019051-gtruu1op 144 12 for for IN cord-019051-gtruu1op 144 13 paramyxoviruses paramyxovirus NNS cord-019051-gtruu1op 144 14 but but CC cord-019051-gtruu1op 144 15 rather rather RB cord-019051-gtruu1op 144 16 by by IN cord-019051-gtruu1op 144 17 membrane membrane NN cord-019051-gtruu1op 144 18 fusion fusion NN cord-019051-gtruu1op 144 19 which which WDT cord-019051-gtruu1op 144 20 may may MD cord-019051-gtruu1op 144 21 involve involve VB cord-019051-gtruu1op 144 22 clathrin clathrin NN cord-019051-gtruu1op 144 23 - - HYPH cord-019051-gtruu1op 144 24 mediated mediate VBN cord-019051-gtruu1op 144 25 endocytosis endocytosis NN cord-019051-gtruu1op 144 26 [ [ -LRB- cord-019051-gtruu1op 144 27 46 46 CD cord-019051-gtruu1op 144 28 ] ] -RRB- cord-019051-gtruu1op 144 29 . . . cord-019051-gtruu1op 145 1 The the DT cord-019051-gtruu1op 145 2 unsegmented unsegmented JJ cord-019051-gtruu1op 145 3 genome genome NN cord-019051-gtruu1op 145 4 contains contain VBZ cord-019051-gtruu1op 145 5 a a DT cord-019051-gtruu1op 145 6 single single JJ cord-019051-gtruu1op 145 7 molecule molecule NN cord-019051-gtruu1op 145 8 of of IN cord-019051-gtruu1op 145 9 linear linear JJ cord-019051-gtruu1op 145 10 negativesense negativesense NN cord-019051-gtruu1op 145 11 , , , cord-019051-gtruu1op 145 12 single single RB cord-019051-gtruu1op 145 13 - - HYPH cord-019051-gtruu1op 145 14 stranded strand VBN cord-019051-gtruu1op 145 15 RNA RNA NNP cord-019051-gtruu1op 145 16 . . . cord-019051-gtruu1op 146 1 Virions Virions NNP cord-019051-gtruu1op 146 2 occasionally occasionally RB cord-019051-gtruu1op 146 3 contain contain VBP cord-019051-gtruu1op 146 4 a a DT cord-019051-gtruu1op 146 5 positive positive JJ cord-019051-gtruu1op 146 6 - - HYPH cord-019051-gtruu1op 146 7 sense sense NN cord-019051-gtruu1op 146 8 single single JJ cord-019051-gtruu1op 146 9 - - HYPH cord-019051-gtruu1op 146 10 stranded stranded JJ cord-019051-gtruu1op 146 11 copy copy NN cord-019051-gtruu1op 146 12 of of IN cord-019051-gtruu1op 146 13 the the DT cord-019051-gtruu1op 146 14 genome genome NN cord-019051-gtruu1op 146 15 ( ( -LRB- cord-019051-gtruu1op 146 16 partial partial JJ cord-019051-gtruu1op 146 17 self self NN cord-019051-gtruu1op 146 18 - - HYPH cord-019051-gtruu1op 146 19 annealing annealing NN cord-019051-gtruu1op 146 20 of of IN cord-019051-gtruu1op 146 21 extracted extract VBN cord-019051-gtruu1op 146 22 RNA RNA NNP cord-019051-gtruu1op 146 23 may may MD cord-019051-gtruu1op 146 24 occur occur VB cord-019051-gtruu1op 146 25 ) ) -RRB- cord-019051-gtruu1op 146 26 . . . cord-019051-gtruu1op 147 1 The the DT cord-019051-gtruu1op 147 2 complete complete JJ cord-019051-gtruu1op 147 3 genome genome NN cord-019051-gtruu1op 147 4 is be VBZ cord-019051-gtruu1op 147 5 approximately approximately RB cord-019051-gtruu1op 147 6 15 15 CD cord-019051-gtruu1op 147 7 300 300 CD cord-019051-gtruu1op 147 8 nucleotides nucleotide NNS cord-019051-gtruu1op 147 9 long long JJ cord-019051-gtruu1op 147 10 and and CC cord-019051-gtruu1op 147 11 fully fully RB cord-019051-gtruu1op 147 12 sequenced sequence VBN cord-019051-gtruu1op 147 13 . . . cord-019051-gtruu1op 148 1 The the DT cord-019051-gtruu1op 148 2 genome genome NN cord-019051-gtruu1op 148 3 has have VBZ cord-019051-gtruu1op 148 4 the the DT cord-019051-gtruu1op 148 5 accession accession NN cord-019051-gtruu1op 148 6 number(s number(s RB cord-019051-gtruu1op 148 7 ) ) -RRB- cord-019051-gtruu1op 149 1 [ [ -LRB- cord-019051-gtruu1op 149 2 D00386 D00386 NNP cord-019051-gtruu1op 149 3 ] ] -RRB- cord-019051-gtruu1op 149 4 -[D00397 -[d00397 NN cord-019051-gtruu1op 149 5 ] ] -RRB- cord-019051-gtruu1op 150 1 [ [ -LRB- cord-019051-gtruu1op 150 2 43 43 CD cord-019051-gtruu1op 150 3 ] ] -RRB- cord-019051-gtruu1op 150 4 . . . cord-019051-gtruu1op 151 1 The the DT cord-019051-gtruu1op 151 2 RNA RNA NNP cord-019051-gtruu1op 151 3 genome genome NN cord-019051-gtruu1op 151 4 has have VBZ cord-019051-gtruu1op 151 5 a a DT cord-019051-gtruu1op 151 6 3'-extragenic 3'-extragenic CD cord-019051-gtruu1op 151 7 leader leader NN cord-019051-gtruu1op 151 8 region region NN cord-019051-gtruu1op 151 9 , , , cord-019051-gtruu1op 151 10 followed follow VBN cord-019051-gtruu1op 151 11 by by IN cord-019051-gtruu1op 151 12 the the DT cord-019051-gtruu1op 151 13 ten ten CD cord-019051-gtruu1op 151 14 viral viral JJ cord-019051-gtruu1op 151 15 genes gene NNS cord-019051-gtruu1op 151 16 and and CC cord-019051-gtruu1op 151 17 a a DT cord-019051-gtruu1op 151 18 5 5 CD cord-019051-gtruu1op 151 19 ' ' '' cord-019051-gtruu1op 151 20 trailer trailer NN cord-019051-gtruu1op 151 21 region region NN cord-019051-gtruu1op 151 22 . . . cord-019051-gtruu1op 152 1 Each each DT cord-019051-gtruu1op 152 2 gene gene NN cord-019051-gtruu1op 152 3 is be VBZ cord-019051-gtruu1op 152 4 transcribed transcribe VBN cord-019051-gtruu1op 152 5 into into IN cord-019051-gtruu1op 152 6 a a DT cord-019051-gtruu1op 152 7 separate separate JJ cord-019051-gtruu1op 152 8 mRNA mrna NN cord-019051-gtruu1op 152 9 encoding encode VBG cord-019051-gtruu1op 152 10 for for IN cord-019051-gtruu1op 152 11 a a DT cord-019051-gtruu1op 152 12 single single JJ cord-019051-gtruu1op 152 13 viral viral JJ cord-019051-gtruu1op 152 14 protein protein NN cord-019051-gtruu1op 152 15 with with IN cord-019051-gtruu1op 152 16 the the DT cord-019051-gtruu1op 152 17 exception exception NN cord-019051-gtruu1op 152 18 of of IN cord-019051-gtruu1op 152 19 the the DT cord-019051-gtruu1op 152 20 M2 M2 NNP cord-019051-gtruu1op 152 21 mRNA mrna NN cord-019051-gtruu1op 152 22 . . . cord-019051-gtruu1op 153 1 This this DT cord-019051-gtruu1op 153 2 contains contain VBZ cord-019051-gtruu1op 153 3 two two CD cord-019051-gtruu1op 153 4 overlapping overlap VBG cord-019051-gtruu1op 153 5 ORF ORF NNP cord-019051-gtruu1op 153 6 , , , cord-019051-gtruu1op 153 7 expressed express VBN cord-019051-gtruu1op 153 8 by by IN cord-019051-gtruu1op 153 9 a a DT cord-019051-gtruu1op 153 10 ribosomal ribosomal JJ cord-019051-gtruu1op 153 11 stop stop VB cord-019051-gtruu1op 153 12 - - HYPH cord-019051-gtruu1op 153 13 restart restart NN cord-019051-gtruu1op 153 14 mechanism mechanism NN cord-019051-gtruu1op 153 15 into into IN cord-019051-gtruu1op 153 16 two two CD cord-019051-gtruu1op 153 17 proteins protein NNS cord-019051-gtruu1op 153 18 , , , cord-019051-gtruu1op 153 19 M2 M2 NNP cord-019051-gtruu1op 153 20 - - SYM cord-019051-gtruu1op 153 21 1 1 CD cord-019051-gtruu1op 153 22 and and CC cord-019051-gtruu1op 153 23 M2 M2 NNP cord-019051-gtruu1op 153 24 - - SYM cord-019051-gtruu1op 153 25 2 2 CD cord-019051-gtruu1op 153 26 [ [ -LRB- cord-019051-gtruu1op 153 27 47 47 CD cord-019051-gtruu1op 153 28 ] ] -RRB- cord-019051-gtruu1op 153 29 . . . cord-019051-gtruu1op 154 1 Although although IN cord-019051-gtruu1op 154 2 gene gene NN cord-019051-gtruu1op 154 3 expression expression NN cord-019051-gtruu1op 154 4 is be VBZ cord-019051-gtruu1op 154 5 consistent consistent JJ cord-019051-gtruu1op 154 6 with with IN cord-019051-gtruu1op 154 7 that that DT cord-019051-gtruu1op 154 8 of of IN cord-019051-gtruu1op 154 9 other other JJ cord-019051-gtruu1op 154 10 members member NNS cord-019051-gtruu1op 154 11 of of IN cord-019051-gtruu1op 154 12 the the DT cord-019051-gtruu1op 154 13 order order NN cord-019051-gtruu1op 154 14 of of IN cord-019051-gtruu1op 154 15 Mononegavirales Mononegavirales NNP cord-019051-gtruu1op 154 16 M2 M2 NNP cord-019051-gtruu1op 154 17 - - HYPH cord-019051-gtruu1op 154 18 1 1 CD cord-019051-gtruu1op 154 19 and and CC cord-019051-gtruu1op 154 20 M2 M2 NNP cord-019051-gtruu1op 154 21 - - SYM cord-019051-gtruu1op 154 22 2 2 CD cord-019051-gtruu1op 154 23 have have VBP cord-019051-gtruu1op 154 24 some some DT cord-019051-gtruu1op 154 25 regulatory regulatory JJ cord-019051-gtruu1op 154 26 features feature NNS cord-019051-gtruu1op 154 27 unique unique JJ cord-019051-gtruu1op 154 28 to to IN cord-019051-gtruu1op 154 29 RSV RSV NNP cord-019051-gtruu1op 154 30 [ [ -LRB- cord-019051-gtruu1op 154 31 44 44 CD cord-019051-gtruu1op 154 32 ] ] -RRB- cord-019051-gtruu1op 154 33 . . . cord-019051-gtruu1op 155 1 The the DT cord-019051-gtruu1op 155 2 five five CD cord-019051-gtruu1op 155 3 nucleocapsid nucleocapsid NN cord-019051-gtruu1op 155 4 - - HYPH cord-019051-gtruu1op 155 5 associated associate VBN cord-019051-gtruu1op 155 6 proteins protein NNS cord-019051-gtruu1op 155 7 are be VBP cord-019051-gtruu1op 155 8 the the DT cord-019051-gtruu1op 155 9 N N NNP cord-019051-gtruu1op 155 10 ( ( -LRB- cord-019051-gtruu1op 155 11 nucleocapsid nucleocapsid NN cord-019051-gtruu1op 155 12 ) ) -RRB- cord-019051-gtruu1op 155 13 protein protein NN cord-019051-gtruu1op 155 14 , , , cord-019051-gtruu1op 155 15 the the DT cord-019051-gtruu1op 155 16 phosphoprotein phosphoprotein NN cord-019051-gtruu1op 155 17 P p NN cord-019051-gtruu1op 155 18 ( ( -LRB- cord-019051-gtruu1op 155 19 co co NN cord-019051-gtruu1op 155 20 - - NN cord-019051-gtruu1op 155 21 factor factor NN cord-019051-gtruu1op 155 22 for for IN cord-019051-gtruu1op 155 23 RNA RNA NNP cord-019051-gtruu1op 155 24 synthesis synthesis NN cord-019051-gtruu1op 155 25 ) ) -RRB- cord-019051-gtruu1op 155 26 , , , cord-019051-gtruu1op 155 27 the the DT cord-019051-gtruu1op 155 28 L L NNP cord-019051-gtruu1op 155 29 protein protein NN cord-019051-gtruu1op 155 30 ( ( -LRB- cord-019051-gtruu1op 155 31 large large JJ cord-019051-gtruu1op 155 32 , , , cord-019051-gtruu1op 155 33 a a DT cord-019051-gtruu1op 155 34 2165-amino 2165-amino CD cord-019051-gtruu1op 155 35 acid acid NN cord-019051-gtruu1op 155 36 subunit subunit NN cord-019051-gtruu1op 155 37 of of IN cord-019051-gtruu1op 155 38 viral viral JJ cord-019051-gtruu1op 155 39 polymerase polymerase NN cord-019051-gtruu1op 155 40 ) ) -RRB- cord-019051-gtruu1op 155 41 , , , cord-019051-gtruu1op 155 42 the the DT cord-019051-gtruu1op 155 43 M2 M2 NNP cord-019051-gtruu1op 155 44 - - HYPH cord-019051-gtruu1op 155 45 1 1 CD cord-019051-gtruu1op 155 46 ( ( -LRB- cord-019051-gtruu1op 155 47 transcription transcription NN cord-019051-gtruu1op 155 48 processivity processivity NN cord-019051-gtruu1op 155 49 factor factor NN cord-019051-gtruu1op 155 50 ) ) -RRB- cord-019051-gtruu1op 155 51 and and CC cord-019051-gtruu1op 155 52 the the DT cord-019051-gtruu1op 155 53 M2 M2 NNP cord-019051-gtruu1op 155 54 - - SYM cord-019051-gtruu1op 155 55 2 2 CD cord-019051-gtruu1op 155 56 protein protein NN cord-019051-gtruu1op 155 57 ( ( -LRB- cord-019051-gtruu1op 155 58 which which WDT cord-019051-gtruu1op 155 59 possesses possess VBZ cord-019051-gtruu1op 155 60 regulatory regulatory JJ cord-019051-gtruu1op 155 61 functions function NNS cord-019051-gtruu1op 155 62 ) ) -RRB- cord-019051-gtruu1op 155 63 [ [ -LRB- cord-019051-gtruu1op 155 64 44 44 CD cord-019051-gtruu1op 155 65 , , , cord-019051-gtruu1op 155 66 48 48 CD cord-019051-gtruu1op 155 67 ] ] -RRB- cord-019051-gtruu1op 155 68 . . . cord-019051-gtruu1op 156 1 The the DT cord-019051-gtruu1op 156 2 N N NNP cord-019051-gtruu1op 156 3 protein protein NN cord-019051-gtruu1op 156 4 binds bind VBZ cord-019051-gtruu1op 157 1 the the DT cord-019051-gtruu1op 157 2 genomic genomic NN cord-019051-gtruu1op 157 3 and and CC cord-019051-gtruu1op 157 4 the the DT cord-019051-gtruu1op 157 5 antigenomic antigenomic JJ cord-019051-gtruu1op 157 6 ( ( -LRB- cord-019051-gtruu1op 157 7 positive positive JJ cord-019051-gtruu1op 157 8 - - HYPH cord-019051-gtruu1op 157 9 sense sense NN cord-019051-gtruu1op 157 10 intermediate intermediate JJ cord-019051-gtruu1op 157 11 ) ) -RRB- cord-019051-gtruu1op 157 12 RNA RNA NNP cord-019051-gtruu1op 157 13 and and CC cord-019051-gtruu1op 157 14 protects protect VBZ cord-019051-gtruu1op 157 15 is be VBZ cord-019051-gtruu1op 157 16 against against IN cord-019051-gtruu1op 157 17 degradation degradation NN cord-019051-gtruu1op 157 18 . . . cord-019051-gtruu1op 158 1 In in IN cord-019051-gtruu1op 158 2 addition addition NN cord-019051-gtruu1op 158 3 , , , cord-019051-gtruu1op 158 4 it -PRON- PRP cord-019051-gtruu1op 158 5 reduces reduce VBZ cord-019051-gtruu1op 158 6 the the DT cord-019051-gtruu1op 158 7 detection detection NN cord-019051-gtruu1op 158 8 and and CC cord-019051-gtruu1op 158 9 responses response NNS cord-019051-gtruu1op 158 10 by by IN cord-019051-gtruu1op 158 11 the the DT cord-019051-gtruu1op 158 12 host host NN cord-019051-gtruu1op 158 13 's 's POS cord-019051-gtruu1op 158 14 immune immune JJ cord-019051-gtruu1op 158 15 system system NN cord-019051-gtruu1op 158 16 ( ( -LRB- cord-019051-gtruu1op 158 17 for for IN cord-019051-gtruu1op 158 18 instance instance NN cord-019051-gtruu1op 158 19 Toll toll NN cord-019051-gtruu1op 158 20 - - HYPH cord-019051-gtruu1op 158 21 like like JJ cord-019051-gtruu1op 158 22 receptors receptor NNS cord-019051-gtruu1op 158 23 , , , cord-019051-gtruu1op 158 24 TLRs TLRs NNP cord-019051-gtruu1op 158 25 ) ) -RRB- cord-019051-gtruu1op 158 26 and and CC cord-019051-gtruu1op 158 27 intracellular intracellular JJ cord-019051-gtruu1op 158 28 RNA RNA NNP cord-019051-gtruu1op 158 29 recognition recognition NN cord-019051-gtruu1op 158 30 helicases helicase NNS cord-019051-gtruu1op 158 31 , , , cord-019051-gtruu1op 158 32 which which WDT cord-019051-gtruu1op 158 33 initiate initiate VBP cord-019051-gtruu1op 158 34 innate innate JJ cord-019051-gtruu1op 158 35 immune immune JJ cord-019051-gtruu1op 158 36 responses response NNS cord-019051-gtruu1op 158 37 [ [ -LRB- cord-019051-gtruu1op 158 38 44 44 CD cord-019051-gtruu1op 158 39 , , , cord-019051-gtruu1op 158 40 49 49 CD cord-019051-gtruu1op 158 41 , , , cord-019051-gtruu1op 158 42 50 50 CD cord-019051-gtruu1op 158 43 ] ] -RRB- cord-019051-gtruu1op 158 44 . . . cord-019051-gtruu1op 159 1 The the DT cord-019051-gtruu1op 159 2 viral viral JJ cord-019051-gtruu1op 159 3 envelope envelope NN cord-019051-gtruu1op 159 4 is be VBZ cord-019051-gtruu1op 159 5 formed form VBN cord-019051-gtruu1op 159 6 by by IN cord-019051-gtruu1op 159 7 four four CD cord-019051-gtruu1op 159 8 RSV RSV NNP cord-019051-gtruu1op 159 9 proteins protein NNS cord-019051-gtruu1op 159 10 that that WDT cord-019051-gtruu1op 159 11 associate associate VBP cord-019051-gtruu1op 159 12 with with IN cord-019051-gtruu1op 159 13 the the DT cord-019051-gtruu1op 159 14 lipid lipid NN cord-019051-gtruu1op 159 15 bilayer bilayer NN cord-019051-gtruu1op 159 16 : : : cord-019051-gtruu1op 159 17 a a DT cord-019051-gtruu1op 159 18 matrix matrix NN cord-019051-gtruu1op 159 19 ( ( -LRB- cord-019051-gtruu1op 159 20 M M NNP cord-019051-gtruu1op 159 21 ) ) -RRB- cord-019051-gtruu1op 159 22 protein protein NN cord-019051-gtruu1op 159 23 that that WDT cord-019051-gtruu1op 159 24 is be VBZ cord-019051-gtruu1op 159 25 located locate VBN cord-019051-gtruu1op 159 26 at at IN cord-019051-gtruu1op 159 27 the the DT cord-019051-gtruu1op 159 28 inner inner JJ cord-019051-gtruu1op 159 29 surface surface NN cord-019051-gtruu1op 159 30 and and CC cord-019051-gtruu1op 159 31 is be VBZ cord-019051-gtruu1op 159 32 important important JJ cord-019051-gtruu1op 159 33 for for IN cord-019051-gtruu1op 159 34 the the DT cord-019051-gtruu1op 159 35 assembly assembly NN cord-019051-gtruu1op 159 36 of of IN cord-019051-gtruu1op 159 37 the the DT cord-019051-gtruu1op 159 38 virion virion NN cord-019051-gtruu1op 159 39 [ [ -LRB- cord-019051-gtruu1op 159 40 51 51 CD cord-019051-gtruu1op 159 41 ] ] -RRB- cord-019051-gtruu1op 159 42 , , , cord-019051-gtruu1op 159 43 a a DT cord-019051-gtruu1op 159 44 glycosylated glycosylated JJ cord-019051-gtruu1op 159 45 ( ( -LRB- cord-019051-gtruu1op 159 46 G g NN cord-019051-gtruu1op 159 47 ) ) -RRB- cord-019051-gtruu1op 159 48 protein protein NN cord-019051-gtruu1op 159 49 , , , cord-019051-gtruu1op 159 50 a a DT cord-019051-gtruu1op 159 51 fusion fusion NN cord-019051-gtruu1op 159 52 ( ( -LRB- cord-019051-gtruu1op 159 53 F F NNP cord-019051-gtruu1op 159 54 ) ) -RRB- cord-019051-gtruu1op 159 55 protein protein NN cord-019051-gtruu1op 159 56 and and CC cord-019051-gtruu1op 159 57 a a DT cord-019051-gtruu1op 159 58 small small JJ cord-019051-gtruu1op 159 59 hydrophobic hydrophobic JJ cord-019051-gtruu1op 159 60 ( ( -LRB- cord-019051-gtruu1op 159 61 SH sh NN cord-019051-gtruu1op 159 62 ) ) -RRB- cord-019051-gtruu1op 159 63 protein protein NN cord-019051-gtruu1op 159 64 . . . cord-019051-gtruu1op 160 1 Two two CD cord-019051-gtruu1op 160 2 other other JJ cord-019051-gtruu1op 160 3 RSV RSV NNP cord-019051-gtruu1op 160 4 proteins protein NNS cord-019051-gtruu1op 160 5 , , , cord-019051-gtruu1op 160 6 the the DT cord-019051-gtruu1op 160 7 NS1 ns1 NN cord-019051-gtruu1op 160 8 and and CC cord-019051-gtruu1op 160 9 NS2 NS2 NNP cord-019051-gtruu1op 160 10 proteins protein NNS cord-019051-gtruu1op 160 11 are be VBP cord-019051-gtruu1op 160 12 a a DT cord-019051-gtruu1op 160 13 minor minor JJ cord-019051-gtruu1op 160 14 part part NN cord-019051-gtruu1op 160 15 of of IN cord-019051-gtruu1op 160 16 the the DT cord-019051-gtruu1op 160 17 virion virion NN cord-019051-gtruu1op 160 18 [ [ -LRB- cord-019051-gtruu1op 160 19 44 44 CD cord-019051-gtruu1op 160 20 ] ] -RRB- cord-019051-gtruu1op 160 21 . . . cord-019051-gtruu1op 161 1 NS1 ns1 UH cord-019051-gtruu1op 161 2 and and CC cord-019051-gtruu1op 161 3 NS2 NS2 NNP cord-019051-gtruu1op 161 4 are be VBP cord-019051-gtruu1op 161 5 thought think VBN cord-019051-gtruu1op 161 6 to to TO cord-019051-gtruu1op 161 7 modulate modulate VB cord-019051-gtruu1op 161 8 the the DT cord-019051-gtruu1op 161 9 host host NN cord-019051-gtruu1op 161 10 response response NN cord-019051-gtruu1op 161 11 to to IN cord-019051-gtruu1op 161 12 RSV RSV NNP cord-019051-gtruu1op 161 13 infection infection NN cord-019051-gtruu1op 161 14 . . . cord-019051-gtruu1op 162 1 The the DT cord-019051-gtruu1op 162 2 G g NN cord-019051-gtruu1op 162 3 glycoprotein glycoprotein NN cord-019051-gtruu1op 162 4 ( ( -LRB- cord-019051-gtruu1op 162 5 ~90 ~90 NNP cord-019051-gtruu1op 162 6 kDa kDa NNP cord-019051-gtruu1op 162 7 ) ) -RRB- cord-019051-gtruu1op 162 8 has have VBZ cord-019051-gtruu1op 162 9 a a DT cord-019051-gtruu1op 162 10 peptide peptide NN cord-019051-gtruu1op 162 11 backbone backbone NN cord-019051-gtruu1op 162 12 with with IN cord-019051-gtruu1op 162 13 24 24 CD cord-019051-gtruu1op 162 14 - - SYM cord-019051-gtruu1op 162 15 25 25 CD cord-019051-gtruu1op 162 16 side side NN cord-019051-gtruu1op 162 17 chains chain NNS cord-019051-gtruu1op 162 18 and and CC cord-019051-gtruu1op 162 19 is be VBZ cord-019051-gtruu1op 162 20 important important JJ cord-019051-gtruu1op 162 21 for for IN cord-019051-gtruu1op 162 22 viral viral JJ cord-019051-gtruu1op 162 23 attachment attachment NN cord-019051-gtruu1op 162 24 to to IN cord-019051-gtruu1op 162 25 the the DT cord-019051-gtruu1op 162 26 host host NN cord-019051-gtruu1op 162 27 cell cell NN cord-019051-gtruu1op 162 28 [ [ -LRB- cord-019051-gtruu1op 162 29 52 52 CD cord-019051-gtruu1op 162 30 ] ] -RRB- cord-019051-gtruu1op 162 31 . . . cord-019051-gtruu1op 163 1 A a DT cord-019051-gtruu1op 163 2 second second JJ cord-019051-gtruu1op 163 3 secretory secretory JJ cord-019051-gtruu1op 163 4 form form NN cord-019051-gtruu1op 163 5 of of IN cord-019051-gtruu1op 163 6 the the DT cord-019051-gtruu1op 163 7 G g NN cord-019051-gtruu1op 163 8 protein protein NN cord-019051-gtruu1op 163 9 exists exist VBZ cord-019051-gtruu1op 163 10 that that DT cord-019051-gtruu1op 163 11 arises arise VBZ cord-019051-gtruu1op 163 12 from from IN cord-019051-gtruu1op 163 13 a a DT cord-019051-gtruu1op 163 14 second second JJ cord-019051-gtruu1op 163 15 initiation initiation NN cord-019051-gtruu1op 163 16 codon codon NN cord-019051-gtruu1op 163 17 in in IN cord-019051-gtruu1op 163 18 the the DT cord-019051-gtruu1op 163 19 G G NNP cord-019051-gtruu1op 163 20 ORF ORF NNP cord-019051-gtruu1op 163 21 . . . cord-019051-gtruu1op 164 1 Proteolytic proteolytic JJ cord-019051-gtruu1op 164 2 trimming trimming NN cord-019051-gtruu1op 164 3 removes remove VBZ cord-019051-gtruu1op 164 4 additional additional JJ cord-019051-gtruu1op 164 5 amino amino NN cord-019051-gtruu1op 164 6 acids acid NNS cord-019051-gtruu1op 164 7 , , , cord-019051-gtruu1op 164 8 and and CC cord-019051-gtruu1op 164 9 the the DT cord-019051-gtruu1op 164 10 final final JJ cord-019051-gtruu1op 164 11 protein protein NN cord-019051-gtruu1op 164 12 lacks lack VBZ cord-019051-gtruu1op 164 13 the the DT cord-019051-gtruu1op 164 14 65 65 CD cord-019051-gtruu1op 164 15 N n CD cord-019051-gtruu1op 164 16 - - HYPH cord-019051-gtruu1op 164 17 terminal terminal NN cord-019051-gtruu1op 164 18 residues residue NNS cord-019051-gtruu1op 164 19 , , , cord-019051-gtruu1op 164 20 including include VBG cord-019051-gtruu1op 164 21 the the DT cord-019051-gtruu1op 164 22 membrane membrane NN cord-019051-gtruu1op 164 23 anchor anchor NN cord-019051-gtruu1op 164 24 [ [ -LRB- cord-019051-gtruu1op 164 25 44 44 CD cord-019051-gtruu1op 164 26 , , , cord-019051-gtruu1op 164 27 52 52 CD cord-019051-gtruu1op 164 28 ] ] -RRB- cord-019051-gtruu1op 164 29 . . . cord-019051-gtruu1op 165 1 The the DT cord-019051-gtruu1op 165 2 ectodomain ectodomain NN cord-019051-gtruu1op 165 3 of of IN cord-019051-gtruu1op 165 4 the the DT cord-019051-gtruu1op 165 5 G G NNP cord-019051-gtruu1op 165 6 protein protein NN cord-019051-gtruu1op 165 7 has have VBZ cord-019051-gtruu1op 165 8 a a DT cord-019051-gtruu1op 165 9 mucin mucin NN cord-019051-gtruu1op 165 10 - - HYPH cord-019051-gtruu1op 165 11 like like JJ cord-019051-gtruu1op 165 12 structure structure NN cord-019051-gtruu1op 165 13 that that WDT cord-019051-gtruu1op 165 14 differs differ VBZ cord-019051-gtruu1op 165 15 from from IN cord-019051-gtruu1op 165 16 attachment attachment NN cord-019051-gtruu1op 165 17 proteins protein NNS cord-019051-gtruu1op 165 18 of of IN cord-019051-gtruu1op 165 19 other other JJ cord-019051-gtruu1op 165 20 paramyxovirus paramyxovirus NNP cord-019051-gtruu1op 165 21 . . . cord-019051-gtruu1op 166 1 Its -PRON- PRP$ cord-019051-gtruu1op 166 2 function function NN cord-019051-gtruu1op 166 3 is be VBZ cord-019051-gtruu1op 166 4 not not RB cord-019051-gtruu1op 166 5 clear clear JJ cord-019051-gtruu1op 166 6 but but CC cord-019051-gtruu1op 166 7 it -PRON- PRP cord-019051-gtruu1op 166 8 is be VBZ cord-019051-gtruu1op 166 9 thought think VBN cord-019051-gtruu1op 166 10 to to TO cord-019051-gtruu1op 166 11 contribute contribute VB cord-019051-gtruu1op 166 12 to to IN cord-019051-gtruu1op 166 13 virus virus NN cord-019051-gtruu1op 166 14 spread spread VBN cord-019051-gtruu1op 166 15 or or CC cord-019051-gtruu1op 166 16 to to TO cord-019051-gtruu1op 166 17 prevent prevent VB cord-019051-gtruu1op 166 18 trapping trapping NN cord-019051-gtruu1op 166 19 by by IN cord-019051-gtruu1op 166 20 mucus mucus NN cord-019051-gtruu1op 166 21 [ [ -LRB- cord-019051-gtruu1op 166 22 44 44 CD cord-019051-gtruu1op 166 23 ] ] -RRB- cord-019051-gtruu1op 166 24 . . . cord-019051-gtruu1op 167 1 The the DT cord-019051-gtruu1op 167 2 F F NNP cord-019051-gtruu1op 167 3 protein protein NN cord-019051-gtruu1op 167 4 has have VBZ cord-019051-gtruu1op 167 5 two two CD cord-019051-gtruu1op 167 6 distinct distinct JJ cord-019051-gtruu1op 167 7 functions function NNS cord-019051-gtruu1op 167 8 : : : cord-019051-gtruu1op 167 9 penetration penetration NN cord-019051-gtruu1op 167 10 into into IN cord-019051-gtruu1op 167 11 the the DT cord-019051-gtruu1op 167 12 host host NN cord-019051-gtruu1op 167 13 cell cell NN cord-019051-gtruu1op 167 14 by by IN cord-019051-gtruu1op 167 15 membrane membrane NN cord-019051-gtruu1op 167 16 fusion fusion NN cord-019051-gtruu1op 167 17 and and CC cord-019051-gtruu1op 167 18 a a DT cord-019051-gtruu1op 167 19 syncytia syncytia NN cord-019051-gtruu1op 167 20 - - HYPH cord-019051-gtruu1op 167 21 forming form VBG cord-019051-gtruu1op 167 22 property property NN cord-019051-gtruu1op 167 23 . . . cord-019051-gtruu1op 168 1 The the DT cord-019051-gtruu1op 168 2 F F NNP cord-019051-gtruu1op 168 3 protein protein NN cord-019051-gtruu1op 168 4 matures mature VBZ cord-019051-gtruu1op 168 5 by by IN cord-019051-gtruu1op 168 6 activation activation NN cord-019051-gtruu1op 168 7 through through IN cord-019051-gtruu1op 168 8 a a DT cord-019051-gtruu1op 168 9 furin furin NN cord-019051-gtruu1op 168 10 - - HYPH cord-019051-gtruu1op 168 11 like like JJ cord-019051-gtruu1op 168 12 intracellular intracellular JJ cord-019051-gtruu1op 168 13 protease protease NN cord-019051-gtruu1op 168 14 that that WDT cord-019051-gtruu1op 168 15 cleaves cleave VBZ cord-019051-gtruu1op 168 16 the the DT cord-019051-gtruu1op 168 17 precursor precursor NN cord-019051-gtruu1op 168 18 , , , cord-019051-gtruu1op 168 19 F F NNP cord-019051-gtruu1op 168 20 0 0 CD cord-019051-gtruu1op 168 21 into into IN cord-019051-gtruu1op 168 22 three three CD cord-019051-gtruu1op 168 23 fragments fragment NNS cord-019051-gtruu1op 168 24 , , , cord-019051-gtruu1op 168 25 F F NNP cord-019051-gtruu1op 168 26 1 1 CD cord-019051-gtruu1op 168 27 , , , cord-019051-gtruu1op 168 28 F F NNP cord-019051-gtruu1op 168 29 2 2 CD cord-019051-gtruu1op 168 30 and and CC cord-019051-gtruu1op 168 31 p27 p27 NN cord-019051-gtruu1op 168 32 . . . cord-019051-gtruu1op 169 1 F F NNP cord-019051-gtruu1op 169 2 1 1 CD cord-019051-gtruu1op 169 3 and and CC cord-019051-gtruu1op 169 4 F F NNP cord-019051-gtruu1op 169 5 2 2 CD cord-019051-gtruu1op 169 6 are be VBP cord-019051-gtruu1op 169 7 linked link VBN cord-019051-gtruu1op 169 8 by by IN cord-019051-gtruu1op 169 9 a a DT cord-019051-gtruu1op 169 10 disulfide disulfide JJ cord-019051-gtruu1op 169 11 bond bond NN cord-019051-gtruu1op 169 12 and and CC cord-019051-gtruu1op 169 13 represent represent VB cord-019051-gtruu1op 169 14 the the DT cord-019051-gtruu1op 169 15 active active JJ cord-019051-gtruu1op 169 16 form form NN cord-019051-gtruu1op 169 17 of of IN cord-019051-gtruu1op 169 18 F F NNP cord-019051-gtruu1op 169 19 [ [ -LRB- cord-019051-gtruu1op 169 20 53 53 CD cord-019051-gtruu1op 169 21 ] ] -RRB- cord-019051-gtruu1op 169 22 . . . cord-019051-gtruu1op 170 1 The the DT cord-019051-gtruu1op 170 2 hydrophobic hydrophobic JJ cord-019051-gtruu1op 170 3 N n CD cord-019051-gtruu1op 170 4 terminus terminus NN cord-019051-gtruu1op 170 5 of of IN cord-019051-gtruu1op 170 6 F F NNP cord-019051-gtruu1op 170 7 1 1 CD cord-019051-gtruu1op 170 8 is be VBZ cord-019051-gtruu1op 170 9 conserved conserve VBN cord-019051-gtruu1op 170 10 within within IN cord-019051-gtruu1op 170 11 the the DT cord-019051-gtruu1op 170 12 RSV RSV NNP cord-019051-gtruu1op 170 13 and and CC cord-019051-gtruu1op 170 14 it -PRON- PRP cord-019051-gtruu1op 170 15 is be VBZ cord-019051-gtruu1op 170 16 thought think VBN cord-019051-gtruu1op 170 17 that that IN cord-019051-gtruu1op 170 18 this this DT cord-019051-gtruu1op 170 19 domain domain NN cord-019051-gtruu1op 170 20 inserts insert VBZ cord-019051-gtruu1op 170 21 into into IN cord-019051-gtruu1op 170 22 the the DT cord-019051-gtruu1op 170 23 host host NN cord-019051-gtruu1op 170 24 cell cell NN cord-019051-gtruu1op 170 25 membrane membrane NN cord-019051-gtruu1op 170 26 when when WRB cord-019051-gtruu1op 170 27 fusion fusion NN cord-019051-gtruu1op 170 28 occurs occur VBZ cord-019051-gtruu1op 170 29 [ [ -LRB- cord-019051-gtruu1op 170 30 44 44 CD cord-019051-gtruu1op 170 31 ] ] -RRB- cord-019051-gtruu1op 170 32 . . . cord-019051-gtruu1op 171 1 NS1 ns1 UH cord-019051-gtruu1op 171 2 and and CC cord-019051-gtruu1op 171 3 NS2 NS2 NNP cord-019051-gtruu1op 171 4 are be VBP cord-019051-gtruu1op 171 5 thought think VBN cord-019051-gtruu1op 171 6 to to TO cord-019051-gtruu1op 171 7 modulate modulate VB cord-019051-gtruu1op 171 8 the the DT cord-019051-gtruu1op 171 9 host host NN cord-019051-gtruu1op 171 10 's 's POS cord-019051-gtruu1op 171 11 immune immune JJ cord-019051-gtruu1op 171 12 response response NN cord-019051-gtruu1op 171 13 to to IN cord-019051-gtruu1op 171 14 RSV RSV NNP cord-019051-gtruu1op 171 15 [ [ -LRB- cord-019051-gtruu1op 171 16 44 44 CD cord-019051-gtruu1op 171 17 ] ] -RRB- cord-019051-gtruu1op 171 18 . . . cord-019051-gtruu1op 172 1 Lack lack NN cord-019051-gtruu1op 172 2 of of IN cord-019051-gtruu1op 172 3 M2 M2 NNP cord-019051-gtruu1op 172 4 - - HYPH cord-019051-gtruu1op 172 5 1 1 CD cord-019051-gtruu1op 172 6 results result NNS cord-019051-gtruu1op 172 7 in in IN cord-019051-gtruu1op 172 8 reduced reduce VBN cord-019051-gtruu1op 172 9 expression expression NN cord-019051-gtruu1op 172 10 of of IN cord-019051-gtruu1op 172 11 NS1 ns1 NN cord-019051-gtruu1op 172 12 and and CC cord-019051-gtruu1op 172 13 NS2 NS2 NNP cord-019051-gtruu1op 172 14 , , , cord-019051-gtruu1op 172 15 and and CC cord-019051-gtruu1op 172 16 it -PRON- PRP cord-019051-gtruu1op 172 17 is be VBZ cord-019051-gtruu1op 172 18 thought think VBN cord-019051-gtruu1op 172 19 that that IN cord-019051-gtruu1op 172 20 this this DT cord-019051-gtruu1op 172 21 down down JJ cord-019051-gtruu1op 172 22 - - HYPH cord-019051-gtruu1op 172 23 regulation regulation NN cord-019051-gtruu1op 172 24 of of IN cord-019051-gtruu1op 172 25 the the DT cord-019051-gtruu1op 172 26 host host NN cord-019051-gtruu1op 172 27 - - HYPH cord-019051-gtruu1op 172 28 defense defense NN cord-019051-gtruu1op 172 29 antagonists antagonist NNS cord-019051-gtruu1op 172 30 may may MD cord-019051-gtruu1op 172 31 help help VB cord-019051-gtruu1op 172 32 to to TO cord-019051-gtruu1op 172 33 facilitate facilitate VB cord-019051-gtruu1op 172 34 persistent persistent JJ cord-019051-gtruu1op 172 35 RSV RSV NNP cord-019051-gtruu1op 172 36 infection infection NN cord-019051-gtruu1op 172 37 [ [ -LRB- cord-019051-gtruu1op 172 38 44 44 CD cord-019051-gtruu1op 172 39 ] ] -RRB- cord-019051-gtruu1op 172 40 . . . cord-019051-gtruu1op 173 1 Infection infection NN cord-019051-gtruu1op 173 2 occurs occur VBZ cord-019051-gtruu1op 173 3 through through IN cord-019051-gtruu1op 173 4 direct direct JJ cord-019051-gtruu1op 173 5 contact contact NN cord-019051-gtruu1op 173 6 , , , cord-019051-gtruu1op 173 7 through through IN cord-019051-gtruu1op 173 8 large large JJ cord-019051-gtruu1op 173 9 respiratory respiratory JJ cord-019051-gtruu1op 173 10 droplets droplet NNS cord-019051-gtruu1op 173 11 and and CC cord-019051-gtruu1op 173 12 , , , cord-019051-gtruu1op 173 13 to to IN cord-019051-gtruu1op 173 14 a a DT cord-019051-gtruu1op 173 15 lesser less JJR cord-019051-gtruu1op 173 16 extent extent NN cord-019051-gtruu1op 173 17 , , , cord-019051-gtruu1op 173 18 through through IN cord-019051-gtruu1op 173 19 small small JJ cord-019051-gtruu1op 173 20 droplets droplet NNS cord-019051-gtruu1op 173 21 . . . cord-019051-gtruu1op 174 1 The the DT cord-019051-gtruu1op 174 2 site site NN cord-019051-gtruu1op 174 3 of of IN cord-019051-gtruu1op 174 4 the the DT cord-019051-gtruu1op 174 5 first first JJ cord-019051-gtruu1op 174 6 replication replication NN cord-019051-gtruu1op 174 7 is be VBZ cord-019051-gtruu1op 174 8 the the DT cord-019051-gtruu1op 174 9 nasopharynx nasopharynx NN cord-019051-gtruu1op 174 10 . . . cord-019051-gtruu1op 175 1 After after IN cord-019051-gtruu1op 175 2 an an DT cord-019051-gtruu1op 175 3 incubation incubation NN cord-019051-gtruu1op 175 4 period period NN cord-019051-gtruu1op 175 5 of of IN cord-019051-gtruu1op 175 6 4 4 CD cord-019051-gtruu1op 175 7 - - SYM cord-019051-gtruu1op 175 8 5 5 CD cord-019051-gtruu1op 175 9 days day NNS cord-019051-gtruu1op 175 10 the the DT cord-019051-gtruu1op 175 11 virus virus NN cord-019051-gtruu1op 175 12 spreads spread VBZ cord-019051-gtruu1op 175 13 to to IN cord-019051-gtruu1op 175 14 the the DT cord-019051-gtruu1op 175 15 lower low JJR cord-019051-gtruu1op 175 16 respiratory respiratory JJ cord-019051-gtruu1op 175 17 tract tract NN cord-019051-gtruu1op 175 18 [ [ -LRB- cord-019051-gtruu1op 175 19 54 54 CD cord-019051-gtruu1op 175 20 , , , cord-019051-gtruu1op 175 21 55 55 CD cord-019051-gtruu1op 175 22 ] ] -RRB- cord-019051-gtruu1op 175 23 . . . cord-019051-gtruu1op 176 1 The the DT cord-019051-gtruu1op 176 2 clinical clinical JJ cord-019051-gtruu1op 176 3 signs sign NNS cord-019051-gtruu1op 176 4 include include VBP cord-019051-gtruu1op 176 5 cough cough NN cord-019051-gtruu1op 176 6 , , , cord-019051-gtruu1op 176 7 rhinitis rhinitis NN cord-019051-gtruu1op 176 8 , , , cord-019051-gtruu1op 176 9 fever fever NN cord-019051-gtruu1op 176 10 and and CC cord-019051-gtruu1op 176 11 signs sign NNS cord-019051-gtruu1op 176 12 of of IN cord-019051-gtruu1op 176 13 bronchiolitis bronchiolitis NN cord-019051-gtruu1op 176 14 like like IN cord-019051-gtruu1op 176 15 air air NN cord-019051-gtruu1op 176 16 trapping trapping NN cord-019051-gtruu1op 176 17 , , , cord-019051-gtruu1op 176 18 wheezing wheezing NN cord-019051-gtruu1op 176 19 and and CC cord-019051-gtruu1op 176 20 increased increase VBN cord-019051-gtruu1op 176 21 airway airway NN cord-019051-gtruu1op 176 22 resistance resistance NN cord-019051-gtruu1op 176 23 . . . cord-019051-gtruu1op 177 1 The the DT cord-019051-gtruu1op 177 2 most most RBS cord-019051-gtruu1op 177 3 prominent prominent JJ cord-019051-gtruu1op 177 4 clinical clinical JJ cord-019051-gtruu1op 177 5 symptoms symptom NNS cord-019051-gtruu1op 177 6 are be VBP cord-019051-gtruu1op 177 7 cough cough NN cord-019051-gtruu1op 177 8 and and CC cord-019051-gtruu1op 177 9 rhinorrhea rhinorrhea NN cord-019051-gtruu1op 177 10 , , , cord-019051-gtruu1op 177 11 which which WDT cord-019051-gtruu1op 177 12 occur occur VBP cord-019051-gtruu1op 177 13 in in IN cord-019051-gtruu1op 177 14 approximately approximately RB cord-019051-gtruu1op 177 15 90 90 CD cord-019051-gtruu1op 177 16 % % NN cord-019051-gtruu1op 177 17 of of IN cord-019051-gtruu1op 177 18 primary primary JJ cord-019051-gtruu1op 177 19 RSV RSV NNP cord-019051-gtruu1op 177 20 infections infection NNS cord-019051-gtruu1op 177 21 in in IN cord-019051-gtruu1op 177 22 infants infant NNS cord-019051-gtruu1op 177 23 and and CC cord-019051-gtruu1op 177 24 to to IN cord-019051-gtruu1op 177 25 some some DT cord-019051-gtruu1op 177 26 lesser less JJR cord-019051-gtruu1op 177 27 extent extent NN cord-019051-gtruu1op 177 28 in in IN cord-019051-gtruu1op 177 29 reinfected reinfected JJ cord-019051-gtruu1op 177 30 adults adult NNS cord-019051-gtruu1op 177 31 [ [ -LRB- cord-019051-gtruu1op 177 32 56 56 CD cord-019051-gtruu1op 177 33 ] ] -RRB- cord-019051-gtruu1op 177 34 . . . cord-019051-gtruu1op 178 1 Fever fever NN cord-019051-gtruu1op 178 2 occurs occur VBZ cord-019051-gtruu1op 178 3 in in IN cord-019051-gtruu1op 178 4 30 30 CD cord-019051-gtruu1op 178 5 - - SYM cord-019051-gtruu1op 178 6 40 40 CD cord-019051-gtruu1op 178 7 % % NN cord-019051-gtruu1op 178 8 of of IN cord-019051-gtruu1op 178 9 both both CC cord-019051-gtruu1op 178 10 infected infected JJ cord-019051-gtruu1op 178 11 infants infant NNS cord-019051-gtruu1op 178 12 and and CC cord-019051-gtruu1op 178 13 adults adult NNS cord-019051-gtruu1op 178 14 and and CC cord-019051-gtruu1op 178 15 otitis otitis NN cord-019051-gtruu1op 178 16 media medium NNS cord-019051-gtruu1op 178 17 is be VBZ cord-019051-gtruu1op 178 18 reported report VBN cord-019051-gtruu1op 178 19 in in IN cord-019051-gtruu1op 178 20 approximately approximately RB cord-019051-gtruu1op 178 21 20 20 CD cord-019051-gtruu1op 178 22 % % NN cord-019051-gtruu1op 178 23 of of IN cord-019051-gtruu1op 178 24 infected infected JJ cord-019051-gtruu1op 178 25 infants infant NNS cord-019051-gtruu1op 178 26 . . . cord-019051-gtruu1op 179 1 Ear ear NN cord-019051-gtruu1op 179 2 and and CC cord-019051-gtruu1op 179 3 sinus sinus NN cord-019051-gtruu1op 179 4 pain pain NN cord-019051-gtruu1op 179 5 is be VBZ cord-019051-gtruu1op 179 6 reported report VBN cord-019051-gtruu1op 179 7 in in IN cord-019051-gtruu1op 179 8 20 20 CD cord-019051-gtruu1op 179 9 - - SYM cord-019051-gtruu1op 179 10 30 30 CD cord-019051-gtruu1op 179 11 % % NN cord-019051-gtruu1op 179 12 of of IN cord-019051-gtruu1op 179 13 infected infected JJ cord-019051-gtruu1op 179 14 adults adult NNS cord-019051-gtruu1op 179 15 . . . cord-019051-gtruu1op 180 1 Symptoms symptom NNS cord-019051-gtruu1op 180 2 of of IN cord-019051-gtruu1op 180 3 LRTI LRTI NNP cord-019051-gtruu1op 180 4 , , , cord-019051-gtruu1op 180 5 including include VBG cord-019051-gtruu1op 180 6 bronchiolitis bronchiolitis NN cord-019051-gtruu1op 180 7 , , , cord-019051-gtruu1op 180 8 pneumonia pneumonia NN cord-019051-gtruu1op 180 9 , , , cord-019051-gtruu1op 180 10 croup croup NN cord-019051-gtruu1op 180 11 , , , cord-019051-gtruu1op 180 12 wheeze wheeze NN cord-019051-gtruu1op 180 13 and and CC cord-019051-gtruu1op 180 14 tracheobronchitis tracheobronchitis NN cord-019051-gtruu1op 180 15 , , , cord-019051-gtruu1op 180 16 are be VBP cord-019051-gtruu1op 180 17 observed observe VBN cord-019051-gtruu1op 180 18 in in IN cord-019051-gtruu1op 180 19 30 30 CD cord-019051-gtruu1op 180 20 - - SYM cord-019051-gtruu1op 180 21 40 40 CD cord-019051-gtruu1op 180 22 % % NN cord-019051-gtruu1op 180 23 of of IN cord-019051-gtruu1op 180 24 infected infected JJ cord-019051-gtruu1op 180 25 infants infant NNS cord-019051-gtruu1op 180 26 and and CC cord-019051-gtruu1op 180 27 to to IN cord-019051-gtruu1op 180 28 some some DT cord-019051-gtruu1op 180 29 lesser less JJR cord-019051-gtruu1op 180 30 extent extent NN cord-019051-gtruu1op 180 31 in in IN cord-019051-gtruu1op 180 32 adults adult NNS cord-019051-gtruu1op 180 33 , , , cord-019051-gtruu1op 180 34 with with IN cord-019051-gtruu1op 180 35 wheeze wheeze NN cord-019051-gtruu1op 180 36 and and CC cord-019051-gtruu1op 180 37 tracheobronchitis tracheobronchitis NN cord-019051-gtruu1op 180 38 being be VBG cord-019051-gtruu1op 180 39 the the DT cord-019051-gtruu1op 180 40 most most RBS cord-019051-gtruu1op 180 41 prominent prominent JJ cord-019051-gtruu1op 180 42 disease disease NN cord-019051-gtruu1op 180 43 symptoms symptom NNS cord-019051-gtruu1op 180 44 . . . cord-019051-gtruu1op 181 1 Hospitalization hospitalization NN cord-019051-gtruu1op 181 2 is be VBZ cord-019051-gtruu1op 181 3 necessary necessary JJ cord-019051-gtruu1op 181 4 in in IN cord-019051-gtruu1op 181 5 approximately approximately RB cord-019051-gtruu1op 181 6 3 3 CD cord-019051-gtruu1op 181 7 % % NN cord-019051-gtruu1op 181 8 of of IN cord-019051-gtruu1op 181 9 infected infected JJ cord-019051-gtruu1op 181 10 children child NNS cord-019051-gtruu1op 181 11 and and CC cord-019051-gtruu1op 181 12 below below IN cord-019051-gtruu1op 181 13 0.1 0.1 CD cord-019051-gtruu1op 181 14 % % NN cord-019051-gtruu1op 181 15 of of IN cord-019051-gtruu1op 181 16 infected infected JJ cord-019051-gtruu1op 181 17 adults adult NNS cord-019051-gtruu1op 181 18 . . . cord-019051-gtruu1op 182 1 RSV RSV NNP cord-019051-gtruu1op 182 2 is be VBZ cord-019051-gtruu1op 182 3 the the DT cord-019051-gtruu1op 182 4 single single JJ cord-019051-gtruu1op 182 5 most most RBS cord-019051-gtruu1op 182 6 important important JJ cord-019051-gtruu1op 182 7 agent agent NN cord-019051-gtruu1op 182 8 in in IN cord-019051-gtruu1op 182 9 children child NNS cord-019051-gtruu1op 182 10 younger young JJR cord-019051-gtruu1op 182 11 than than IN cord-019051-gtruu1op 182 12 3 3 CD cord-019051-gtruu1op 182 13 years year NNS cord-019051-gtruu1op 182 14 of of IN cord-019051-gtruu1op 182 15 age age NN cord-019051-gtruu1op 182 16 . . . cord-019051-gtruu1op 183 1 Importantly importantly RB cord-019051-gtruu1op 183 2 , , , cord-019051-gtruu1op 183 3 children child NNS cord-019051-gtruu1op 183 4 with with IN cord-019051-gtruu1op 183 5 a a DT cord-019051-gtruu1op 183 6 mild mild JJ cord-019051-gtruu1op 183 7 RSV RSV NNP cord-019051-gtruu1op 183 8 disease disease NN cord-019051-gtruu1op 183 9 have have VBP cord-019051-gtruu1op 183 10 also also RB cord-019051-gtruu1op 183 11 been be VBN cord-019051-gtruu1op 183 12 reported report VBN cord-019051-gtruu1op 183 13 to to TO cord-019051-gtruu1op 183 14 have have VB cord-019051-gtruu1op 183 15 recurrent recurrent JJ cord-019051-gtruu1op 183 16 wheezing wheezing NN cord-019051-gtruu1op 183 17 for for IN cord-019051-gtruu1op 183 18 up up IN cord-019051-gtruu1op 183 19 to to TO cord-019051-gtruu1op 183 20 10 10 CD cord-019051-gtruu1op 183 21 years year NNS cord-019051-gtruu1op 183 22 after after IN cord-019051-gtruu1op 183 23 the the DT cord-019051-gtruu1op 183 24 primary primary JJ cord-019051-gtruu1op 183 25 acute acute JJ cord-019051-gtruu1op 183 26 disease disease NN cord-019051-gtruu1op 183 27 [ [ -LRB- cord-019051-gtruu1op 183 28 57 57 CD cord-019051-gtruu1op 183 29 ] ] -RRB- cord-019051-gtruu1op 183 30 . . . cord-019051-gtruu1op 184 1 Extrapulmonary Extrapulmonary NNP cord-019051-gtruu1op 184 2 dissemination dissemination NN cord-019051-gtruu1op 184 3 may may MD cord-019051-gtruu1op 184 4 occur occur VB cord-019051-gtruu1op 184 5 in in IN cord-019051-gtruu1op 184 6 immunocompromised immunocompromised JJ cord-019051-gtruu1op 184 7 patients patient NNS cord-019051-gtruu1op 184 8 [ [ -LRB- cord-019051-gtruu1op 184 9 58 58 CD cord-019051-gtruu1op 184 10 ] ] -RRB- cord-019051-gtruu1op 184 11 . . . cord-019051-gtruu1op 185 1 The the DT cord-019051-gtruu1op 185 2 virus virus NN cord-019051-gtruu1op 185 3 may may MD cord-019051-gtruu1op 185 4 spread spread VB cord-019051-gtruu1op 185 5 to to IN cord-019051-gtruu1op 185 6 kidneys kidney NNS cord-019051-gtruu1op 185 7 , , , cord-019051-gtruu1op 185 8 liver liver NN cord-019051-gtruu1op 185 9 , , , cord-019051-gtruu1op 185 10 the the DT cord-019051-gtruu1op 185 11 central central JJ cord-019051-gtruu1op 185 12 nervous nervous JJ cord-019051-gtruu1op 185 13 system system NN cord-019051-gtruu1op 185 14 and and CC cord-019051-gtruu1op 185 15 the the DT cord-019051-gtruu1op 185 16 heart heart NN cord-019051-gtruu1op 185 17 . . . cord-019051-gtruu1op 186 1 Virus virus NN cord-019051-gtruu1op 186 2 can can MD cord-019051-gtruu1op 186 3 be be VB cord-019051-gtruu1op 186 4 isolated isolate VBN cord-019051-gtruu1op 186 5 from from IN cord-019051-gtruu1op 186 6 the the DT cord-019051-gtruu1op 186 7 nasopharynx nasopharynx NN cord-019051-gtruu1op 186 8 of of IN cord-019051-gtruu1op 186 9 children child NNS cord-019051-gtruu1op 186 10 for for IN cord-019051-gtruu1op 186 11 up up IN cord-019051-gtruu1op 186 12 to to TO cord-019051-gtruu1op 186 13 14 14 CD cord-019051-gtruu1op 186 14 days day NNS cord-019051-gtruu1op 186 15 . . . cord-019051-gtruu1op 187 1 In in IN cord-019051-gtruu1op 187 2 immunocompromised immunocompromised JJ cord-019051-gtruu1op 187 3 patients patient NNS cord-019051-gtruu1op 187 4 , , , cord-019051-gtruu1op 187 5 virus virus NN cord-019051-gtruu1op 187 6 recovery recovery NN cord-019051-gtruu1op 187 7 is be VBZ cord-019051-gtruu1op 187 8 possible possible JJ cord-019051-gtruu1op 187 9 for for IN cord-019051-gtruu1op 187 10 up up IN cord-019051-gtruu1op 187 11 to to TO cord-019051-gtruu1op 187 12 1 1 CD cord-019051-gtruu1op 187 13 month month NN cord-019051-gtruu1op 187 14 or or CC cord-019051-gtruu1op 187 15 even even RB cord-019051-gtruu1op 187 16 longer long RBR cord-019051-gtruu1op 187 17 . . . cord-019051-gtruu1op 188 1 In in IN cord-019051-gtruu1op 188 2 immunocompetent immunocompetent JJ cord-019051-gtruu1op 188 3 individuals individual NNS cord-019051-gtruu1op 188 4 the the DT cord-019051-gtruu1op 188 5 viral viral JJ cord-019051-gtruu1op 188 6 infection infection NN cord-019051-gtruu1op 188 7 is be VBZ cord-019051-gtruu1op 188 8 usually usually RB cord-019051-gtruu1op 188 9 restricted restrict VBN cord-019051-gtruu1op 188 10 to to IN cord-019051-gtruu1op 188 11 the the DT cord-019051-gtruu1op 188 12 superficial superficial JJ cord-019051-gtruu1op 188 13 cells cell NNS cord-019051-gtruu1op 188 14 of of IN cord-019051-gtruu1op 188 15 the the DT cord-019051-gtruu1op 188 16 epithelia epithelium NNS cord-019051-gtruu1op 188 17 and and CC cord-019051-gtruu1op 188 18 viral viral JJ cord-019051-gtruu1op 188 19 spread spread NN cord-019051-gtruu1op 188 20 outside outside IN cord-019051-gtruu1op 188 21 the the DT cord-019051-gtruu1op 188 22 respiratory respiratory JJ cord-019051-gtruu1op 188 23 tract tract NN cord-019051-gtruu1op 188 24 is be VBZ cord-019051-gtruu1op 188 25 uncommon uncommon JJ cord-019051-gtruu1op 188 26 [ [ -LRB- cord-019051-gtruu1op 188 27 54 54 CD cord-019051-gtruu1op 188 28 , , , cord-019051-gtruu1op 188 29 59 59 CD cord-019051-gtruu1op 188 30 ] ] -RRB- cord-019051-gtruu1op 188 31 . . . cord-019051-gtruu1op 189 1 An an DT cord-019051-gtruu1op 189 2 exception exception NN cord-019051-gtruu1op 189 3 , , , cord-019051-gtruu1op 189 4 however however RB cord-019051-gtruu1op 189 5 , , , cord-019051-gtruu1op 189 6 is be VBZ cord-019051-gtruu1op 189 7 the the DT cord-019051-gtruu1op 189 8 middle middle JJ cord-019051-gtruu1op 189 9 ear ear NN cord-019051-gtruu1op 189 10 : : : cord-019051-gtruu1op 189 11 the the DT cord-019051-gtruu1op 189 12 virus virus NN cord-019051-gtruu1op 189 13 frequently frequently RB cord-019051-gtruu1op 189 14 causes cause VBZ cord-019051-gtruu1op 189 15 otitis otitis NN cord-019051-gtruu1op 189 16 media medium NNS cord-019051-gtruu1op 189 17 [ [ -LRB- cord-019051-gtruu1op 189 18 60 60 CD cord-019051-gtruu1op 189 19 ] ] -RRB- cord-019051-gtruu1op 189 20 . . . cord-019051-gtruu1op 190 1 The the DT cord-019051-gtruu1op 190 2 typical typical JJ cord-019051-gtruu1op 190 3 pathological pathological JJ cord-019051-gtruu1op 190 4 findings finding NNS cord-019051-gtruu1op 190 5 in in IN cord-019051-gtruu1op 190 6 RSV RSV NNP cord-019051-gtruu1op 190 7 - - HYPH cord-019051-gtruu1op 190 8 infected infect VBN cord-019051-gtruu1op 190 9 tissue tissue NN cord-019051-gtruu1op 190 10 include include VBP cord-019051-gtruu1op 190 11 epithelial epithelial JJ cord-019051-gtruu1op 190 12 necrosis necrosis NN cord-019051-gtruu1op 190 13 and and CC cord-019051-gtruu1op 190 14 infiltrates infiltrate NNS cord-019051-gtruu1op 190 15 of of IN cord-019051-gtruu1op 190 16 monocytes monocyte NNS cord-019051-gtruu1op 190 17 , , , cord-019051-gtruu1op 190 18 T t NN cord-019051-gtruu1op 190 19 cells cell NNS cord-019051-gtruu1op 190 20 and and CC cord-019051-gtruu1op 190 21 neutrophils neutrophil NNS cord-019051-gtruu1op 190 22 [ [ -LRB- cord-019051-gtruu1op 190 23 61 61 CD cord-019051-gtruu1op 190 24 ] ] -RRB- cord-019051-gtruu1op 190 25 . . . cord-019051-gtruu1op 191 1 Airways airway NNS cord-019051-gtruu1op 191 2 appear appear VBP cord-019051-gtruu1op 191 3 obstructed obstruct VBN cord-019051-gtruu1op 191 4 due due IN cord-019051-gtruu1op 191 5 to to IN cord-019051-gtruu1op 191 6 sloughed slough VBN cord-019051-gtruu1op 191 7 cells cell NNS cord-019051-gtruu1op 191 8 , , , cord-019051-gtruu1op 191 9 mucus mucus NN cord-019051-gtruu1op 191 10 secretion secretion NN cord-019051-gtruu1op 191 11 , , , cord-019051-gtruu1op 191 12 proliferation proliferation NN cord-019051-gtruu1op 191 13 of of IN cord-019051-gtruu1op 191 14 bronchoalveolar bronchoalveolar JJ cord-019051-gtruu1op 191 15 epithelium epithelium NN cord-019051-gtruu1op 191 16 or or CC cord-019051-gtruu1op 191 17 cellular cellular JJ cord-019051-gtruu1op 191 18 infiltration infiltration NN cord-019051-gtruu1op 191 19 . . . cord-019051-gtruu1op 192 1 Formation formation NN cord-019051-gtruu1op 192 2 of of IN cord-019051-gtruu1op 192 3 syncytia syncytia NN cord-019051-gtruu1op 192 4 in in IN cord-019051-gtruu1op 192 5 the the DT cord-019051-gtruu1op 192 6 bronchoalveolar bronchoalveolar JJ cord-019051-gtruu1op 192 7 epithelium epithelium NN cord-019051-gtruu1op 192 8 is be VBZ cord-019051-gtruu1op 192 9 sometimes sometimes RB cord-019051-gtruu1op 192 10 observed observe VBN cord-019051-gtruu1op 192 11 [ [ -LRB- cord-019051-gtruu1op 192 12 61 61 CD cord-019051-gtruu1op 192 13 ] ] -RRB- cord-019051-gtruu1op 192 14 . . . cord-019051-gtruu1op 193 1 However however RB cord-019051-gtruu1op 193 2 , , , cord-019051-gtruu1op 193 3 giant giant JJ cord-019051-gtruu1op 193 4 cell cell NN cord-019051-gtruu1op 193 5 pneumonia pneumonia NN cord-019051-gtruu1op 193 6 or or CC cord-019051-gtruu1op 193 7 syncytia syncytia NN cord-019051-gtruu1op 193 8 formation formation NN cord-019051-gtruu1op 193 9 are be VBP cord-019051-gtruu1op 193 10 related relate VBN cord-019051-gtruu1op 193 11 to to IN cord-019051-gtruu1op 193 12 severe severe JJ cord-019051-gtruu1op 193 13 T T NNP cord-019051-gtruu1op 193 14 cell cell NN cord-019051-gtruu1op 193 15 - - HYPH cord-019051-gtruu1op 193 16 deficient deficient JJ cord-019051-gtruu1op 193 17 patients patient NNS cord-019051-gtruu1op 193 18 [ [ -LRB- cord-019051-gtruu1op 193 19 44 44 CD cord-019051-gtruu1op 193 20 ] ] -RRB- cord-019051-gtruu1op 193 21 . . . cord-019051-gtruu1op 194 1 Specific specific JJ cord-019051-gtruu1op 194 2 host host NN cord-019051-gtruu1op 194 3 factors factor NNS cord-019051-gtruu1op 194 4 that that WDT cord-019051-gtruu1op 194 5 may may MD cord-019051-gtruu1op 194 6 influence influence VB cord-019051-gtruu1op 194 7 the the DT cord-019051-gtruu1op 194 8 clinical clinical JJ cord-019051-gtruu1op 194 9 signs sign NNS cord-019051-gtruu1op 194 10 and and CC cord-019051-gtruu1op 194 11 outcome outcome NN cord-019051-gtruu1op 194 12 of of IN cord-019051-gtruu1op 194 13 RSV RSV NNP cord-019051-gtruu1op 194 14 infection infection NN cord-019051-gtruu1op 194 15 including include VBG cord-019051-gtruu1op 194 16 the the DT cord-019051-gtruu1op 194 17 general general JJ cord-019051-gtruu1op 194 18 health health NN cord-019051-gtruu1op 194 19 status status NN cord-019051-gtruu1op 194 20 , , , cord-019051-gtruu1op 194 21 the the DT cord-019051-gtruu1op 194 22 nutritional nutritional JJ cord-019051-gtruu1op 194 23 status status NN cord-019051-gtruu1op 194 24 [ [ -LRB- cord-019051-gtruu1op 194 25 56 56 CD cord-019051-gtruu1op 194 26 , , , cord-019051-gtruu1op 194 27 62 62 CD cord-019051-gtruu1op 194 28 , , , cord-019051-gtruu1op 194 29 63 63 CD cord-019051-gtruu1op 194 30 ] ] -RRB- cord-019051-gtruu1op 194 31 , , , cord-019051-gtruu1op 194 32 gender gender NN cord-019051-gtruu1op 194 33 , , , cord-019051-gtruu1op 194 34 ethnic ethnic JJ cord-019051-gtruu1op 194 35 group group NN cord-019051-gtruu1op 194 36 , , , cord-019051-gtruu1op 194 37 levels level NNS cord-019051-gtruu1op 194 38 of of IN cord-019051-gtruu1op 194 39 maternal maternal JJ cord-019051-gtruu1op 194 40 antibodies antibody NNS cord-019051-gtruu1op 194 41 [ [ -LRB- cord-019051-gtruu1op 194 42 64 64 CD cord-019051-gtruu1op 194 43 ] ] -RRB- cord-019051-gtruu1op 194 44 , , , cord-019051-gtruu1op 194 45 age age NN cord-019051-gtruu1op 194 46 of of IN cord-019051-gtruu1op 194 47 first first JJ cord-019051-gtruu1op 194 48 RSV RSV NNP cord-019051-gtruu1op 194 49 infection infection NN cord-019051-gtruu1op 194 50 [ [ -LRB- cord-019051-gtruu1op 194 51 65 65 CD cord-019051-gtruu1op 194 52 ] ] -RRB- cord-019051-gtruu1op 194 53 and and CC cord-019051-gtruu1op 194 54 underlying underlie VBG cord-019051-gtruu1op 194 55 cardiac cardiac JJ cord-019051-gtruu1op 194 56 or or CC cord-019051-gtruu1op 194 57 pulmonary pulmonary JJ cord-019051-gtruu1op 194 58 diseases disease NNS cord-019051-gtruu1op 194 59 [ [ -LRB- cord-019051-gtruu1op 194 60 66 66 CD cord-019051-gtruu1op 194 61 ] ] -RRB- cord-019051-gtruu1op 194 62 . . . cord-019051-gtruu1op 195 1 In in IN cord-019051-gtruu1op 195 2 addition addition NN cord-019051-gtruu1op 195 3 , , , cord-019051-gtruu1op 195 4 there there EX cord-019051-gtruu1op 195 5 are be VBP cord-019051-gtruu1op 195 6 several several JJ cord-019051-gtruu1op 195 7 environmental environmental JJ cord-019051-gtruu1op 195 8 factors factor NNS cord-019051-gtruu1op 195 9 ( ( -LRB- cord-019051-gtruu1op 195 10 e.g. e.g. RB cord-019051-gtruu1op 195 11 , , , cord-019051-gtruu1op 195 12 tobacco tobacco NN cord-019051-gtruu1op 195 13 use use NN cord-019051-gtruu1op 195 14 in in IN cord-019051-gtruu1op 195 15 household household NN cord-019051-gtruu1op 195 16 , , , cord-019051-gtruu1op 195 17 stress stress NN cord-019051-gtruu1op 195 18 , , , cord-019051-gtruu1op 195 19 day day NN cord-019051-gtruu1op 195 20 care care NN cord-019051-gtruu1op 195 21 ) ) -RRB- cord-019051-gtruu1op 195 22 that that WDT cord-019051-gtruu1op 195 23 may may MD cord-019051-gtruu1op 195 24 influence influence VB cord-019051-gtruu1op 195 25 the the DT cord-019051-gtruu1op 195 26 course course NN cord-019051-gtruu1op 195 27 of of IN cord-019051-gtruu1op 195 28 the the DT cord-019051-gtruu1op 195 29 disease disease NN cord-019051-gtruu1op 195 30 or or CC cord-019051-gtruu1op 195 31 severity severity NN cord-019051-gtruu1op 195 32 of of IN cord-019051-gtruu1op 195 33 symptoms symptom NNS cord-019051-gtruu1op 195 34 . . . cord-019051-gtruu1op 196 1 The the DT cord-019051-gtruu1op 196 2 role role NN cord-019051-gtruu1op 196 3 of of IN cord-019051-gtruu1op 196 4 inflammation inflammation NN cord-019051-gtruu1op 196 5 and and CC cord-019051-gtruu1op 196 6 a a DT cord-019051-gtruu1op 196 7 bias bias NN cord-019051-gtruu1op 196 8 of of IN cord-019051-gtruu1op 196 9 the the DT cord-019051-gtruu1op 196 10 host host NN cord-019051-gtruu1op 196 11 's 's POS cord-019051-gtruu1op 196 12 immune immune JJ cord-019051-gtruu1op 196 13 response response NN cord-019051-gtruu1op 196 14 towards towards IN cord-019051-gtruu1op 196 15 a a DT cord-019051-gtruu1op 196 16 humoral humoral JJ cord-019051-gtruu1op 196 17 Th2 th2 CD cord-019051-gtruu1op 196 18 response response NN cord-019051-gtruu1op 196 19 ( ( -LRB- cord-019051-gtruu1op 196 20 the the DT cord-019051-gtruu1op 196 21 typical typical JJ cord-019051-gtruu1op 196 22 cytokines cytokine NNS cord-019051-gtruu1op 196 23 are be VBP cord-019051-gtruu1op 196 24 IL-4 IL-4 NNP cord-019051-gtruu1op 196 25 , , , cord-019051-gtruu1op 196 26 IL-5 IL-5 NNP cord-019051-gtruu1op 196 27 , , , cord-019051-gtruu1op 196 28 IL-10 IL-10 NNP cord-019051-gtruu1op 196 29 and and CC cord-019051-gtruu1op 196 30 IL-13 IL-13 NNP cord-019051-gtruu1op 196 31 ) ) -RRB- cord-019051-gtruu1op 196 32 are be VBP cord-019051-gtruu1op 196 33 discussed discuss VBN cord-019051-gtruu1op 196 34 controversially controversially RB cord-019051-gtruu1op 196 35 in in IN cord-019051-gtruu1op 196 36 the the DT cord-019051-gtruu1op 196 37 literature literature NN cord-019051-gtruu1op 196 38 . . . cord-019051-gtruu1op 197 1 A a DT cord-019051-gtruu1op 197 2 strong strong JJ cord-019051-gtruu1op 197 3 inflammatory inflammatory JJ cord-019051-gtruu1op 197 4 response response NN cord-019051-gtruu1op 197 5 does do VBZ cord-019051-gtruu1op 197 6 not not RB cord-019051-gtruu1op 197 7 seem seem VB cord-019051-gtruu1op 197 8 to to TO cord-019051-gtruu1op 197 9 be be VB cord-019051-gtruu1op 197 10 determinative determinative JJ cord-019051-gtruu1op 197 11 for for IN cord-019051-gtruu1op 197 12 the the DT cord-019051-gtruu1op 197 13 severity severity NN cord-019051-gtruu1op 197 14 of of IN cord-019051-gtruu1op 197 15 clinical clinical JJ cord-019051-gtruu1op 197 16 symptoms symptom NNS cord-019051-gtruu1op 197 17 [ [ -LRB- cord-019051-gtruu1op 197 18 67 67 CD cord-019051-gtruu1op 197 19 ] ] -RRB- cord-019051-gtruu1op 197 20 , , , cord-019051-gtruu1op 197 21 a a DT cord-019051-gtruu1op 197 22 finding finding NN cord-019051-gtruu1op 197 23 supported support VBN cord-019051-gtruu1op 197 24 by by IN cord-019051-gtruu1op 197 25 the the DT cord-019051-gtruu1op 197 26 fact fact NN cord-019051-gtruu1op 197 27 that that IN cord-019051-gtruu1op 197 28 in in IN cord-019051-gtruu1op 197 29 many many JJ cord-019051-gtruu1op 197 30 clinical clinical JJ cord-019051-gtruu1op 197 31 studies study NNS cord-019051-gtruu1op 197 32 patients patient NNS cord-019051-gtruu1op 197 33 receiving receive VBG cord-019051-gtruu1op 197 34 anti anti JJ cord-019051-gtruu1op 197 35 - - JJ cord-019051-gtruu1op 197 36 inflammatory inflammatory JJ cord-019051-gtruu1op 197 37 therapy therapy NN cord-019051-gtruu1op 197 38 did do VBD cord-019051-gtruu1op 197 39 not not RB cord-019051-gtruu1op 197 40 significantly significantly RB cord-019051-gtruu1op 197 41 benefit benefit VB cord-019051-gtruu1op 197 42 from from IN cord-019051-gtruu1op 197 43 that that DT cord-019051-gtruu1op 197 44 treatment treatment NN cord-019051-gtruu1op 197 45 [ [ -LRB- cord-019051-gtruu1op 197 46 68 68 CD cord-019051-gtruu1op 197 47 ] ] -RRB- cord-019051-gtruu1op 197 48 . . . cord-019051-gtruu1op 198 1 However however RB cord-019051-gtruu1op 198 2 , , , cord-019051-gtruu1op 198 3 strong strong JJ cord-019051-gtruu1op 198 4 inflammatory inflammatory JJ cord-019051-gtruu1op 198 5 responses response NNS cord-019051-gtruu1op 198 6 also also RB cord-019051-gtruu1op 198 7 have have VBP cord-019051-gtruu1op 198 8 been be VBN cord-019051-gtruu1op 198 9 suggested suggest VBN cord-019051-gtruu1op 198 10 to to TO cord-019051-gtruu1op 198 11 enhance enhance VB cord-019051-gtruu1op 198 12 the the DT cord-019051-gtruu1op 198 13 severity severity NN cord-019051-gtruu1op 198 14 of of IN cord-019051-gtruu1op 198 15 clinical clinical JJ cord-019051-gtruu1op 198 16 symptoms symptom NNS cord-019051-gtruu1op 198 17 in in IN cord-019051-gtruu1op 198 18 RSV RSV NNP cord-019051-gtruu1op 198 19 disease disease NN cord-019051-gtruu1op 198 20 . . . cord-019051-gtruu1op 199 1 The the DT cord-019051-gtruu1op 199 2 role role NN cord-019051-gtruu1op 199 3 of of IN cord-019051-gtruu1op 199 4 inflammatory inflammatory JJ cord-019051-gtruu1op 199 5 chemokines chemokine NNS cord-019051-gtruu1op 199 6 in in IN cord-019051-gtruu1op 199 7 RSV RSV NNP cord-019051-gtruu1op 199 8 pathogenesis pathogenesis NN cord-019051-gtruu1op 199 9 has have VBZ cord-019051-gtruu1op 199 10 been be VBN cord-019051-gtruu1op 199 11 supported support VBN cord-019051-gtruu1op 199 12 by by IN cord-019051-gtruu1op 199 13 many many JJ cord-019051-gtruu1op 199 14 preclinical preclinical JJ cord-019051-gtruu1op 199 15 and and CC cord-019051-gtruu1op 199 16 clinical clinical JJ cord-019051-gtruu1op 199 17 studies study NNS cord-019051-gtruu1op 199 18 ( ( -LRB- cord-019051-gtruu1op 199 19 reviewed review VBN cord-019051-gtruu1op 199 20 in in IN cord-019051-gtruu1op 199 21 [ [ -LRB- cord-019051-gtruu1op 199 22 44 44 CD cord-019051-gtruu1op 199 23 ] ] -RRB- cord-019051-gtruu1op 199 24 ) ) -RRB- cord-019051-gtruu1op 199 25 . . . cord-019051-gtruu1op 200 1 For for IN cord-019051-gtruu1op 200 2 example example NN cord-019051-gtruu1op 200 3 , , , cord-019051-gtruu1op 200 4 genetic genetic JJ cord-019051-gtruu1op 200 5 polymorphisms polymorphism NNS cord-019051-gtruu1op 200 6 that that WDT cord-019051-gtruu1op 200 7 increase increase VBP cord-019051-gtruu1op 200 8 IL-8 IL-8 NNP cord-019051-gtruu1op 200 9 , , , cord-019051-gtruu1op 200 10 a a DT cord-019051-gtruu1op 200 11 major major JJ cord-019051-gtruu1op 200 12 chemoattractant chemoattractant NN cord-019051-gtruu1op 200 13 for for IN cord-019051-gtruu1op 200 14 neutrophils neutrophil NNS cord-019051-gtruu1op 200 15 , , , cord-019051-gtruu1op 200 16 and and CC cord-019051-gtruu1op 200 17 CCR5 ccr5 JJ cord-019051-gtruu1op 200 18 expression expression NN cord-019051-gtruu1op 200 19 have have VBP cord-019051-gtruu1op 200 20 been be VBN cord-019051-gtruu1op 200 21 associated associate VBN cord-019051-gtruu1op 200 22 with with IN cord-019051-gtruu1op 200 23 increased increase VBN cord-019051-gtruu1op 200 24 RSV RSV NNP cord-019051-gtruu1op 200 25 disease disease NN cord-019051-gtruu1op 200 26 [ [ -LRB- cord-019051-gtruu1op 200 27 69 69 CD cord-019051-gtruu1op 200 28 ] ] -RRB- cord-019051-gtruu1op 200 29 . . . cord-019051-gtruu1op 201 1 A a DT cord-019051-gtruu1op 201 2 link link NN cord-019051-gtruu1op 201 3 between between IN cord-019051-gtruu1op 201 4 an an DT cord-019051-gtruu1op 201 5 increased increase VBN cord-019051-gtruu1op 201 6 ratio ratio NN cord-019051-gtruu1op 201 7 of of IN cord-019051-gtruu1op 201 8 Th2 Th2 NNP cord-019051-gtruu1op 201 9 / / SYM cord-019051-gtruu1op 201 10 Th1 th1 CD cord-019051-gtruu1op 201 11 immune immune JJ cord-019051-gtruu1op 201 12 response response NN cord-019051-gtruu1op 201 13 ( ( -LRB- cord-019051-gtruu1op 201 14 a a DT cord-019051-gtruu1op 201 15 bias bias NN cord-019051-gtruu1op 201 16 toward toward IN cord-019051-gtruu1op 201 17 the the DT cord-019051-gtruu1op 201 18 humoral humoral JJ cord-019051-gtruu1op 201 19 vs vs IN cord-019051-gtruu1op 201 20 the the DT cord-019051-gtruu1op 201 21 classical classical JJ cord-019051-gtruu1op 201 22 cytotoxic cytotoxic JJ cord-019051-gtruu1op 201 23 response response NN cord-019051-gtruu1op 201 24 ) ) -RRB- cord-019051-gtruu1op 201 25 has have VBZ cord-019051-gtruu1op 201 26 been be VBN cord-019051-gtruu1op 201 27 suggested suggest VBN cord-019051-gtruu1op 201 28 by by IN cord-019051-gtruu1op 201 29 several several JJ cord-019051-gtruu1op 201 30 authors author NNS cord-019051-gtruu1op 201 31 . . . cord-019051-gtruu1op 202 1 This this DT cord-019051-gtruu1op 202 2 discussion discussion NN cord-019051-gtruu1op 202 3 is be VBZ cord-019051-gtruu1op 202 4 based base VBN cord-019051-gtruu1op 202 5 on on IN cord-019051-gtruu1op 202 6 evidence evidence NN cord-019051-gtruu1op 202 7 for for IN cord-019051-gtruu1op 202 8 elevated elevated JJ cord-019051-gtruu1op 202 9 Th2 Th2 NNP cord-019051-gtruu1op 202 10 / / SYM cord-019051-gtruu1op 202 11 Th1 th1 CD cord-019051-gtruu1op 202 12 response response NN cord-019051-gtruu1op 202 13 ratios ratio NNS cord-019051-gtruu1op 202 14 in in IN cord-019051-gtruu1op 202 15 clinical clinical JJ cord-019051-gtruu1op 202 16 studies study NNS cord-019051-gtruu1op 202 17 , , , cord-019051-gtruu1op 202 18 the the DT cord-019051-gtruu1op 202 19 role role NN cord-019051-gtruu1op 202 20 of of IN cord-019051-gtruu1op 202 21 key key JJ cord-019051-gtruu1op 202 22 Th2 Th2 NNP cord-019051-gtruu1op 202 23 cytokines cytokine NNS cord-019051-gtruu1op 202 24 in in IN cord-019051-gtruu1op 202 25 the the DT cord-019051-gtruu1op 202 26 pathogenesis pathogenesis NN cord-019051-gtruu1op 202 27 of of IN cord-019051-gtruu1op 202 28 asthma asthma NN cord-019051-gtruu1op 202 29 and and CC cord-019051-gtruu1op 202 30 the the DT cord-019051-gtruu1op 202 31 experience experience NN cord-019051-gtruu1op 202 32 with with IN cord-019051-gtruu1op 202 33 a a DT cord-019051-gtruu1op 202 34 formalin formalin NN cord-019051-gtruu1op 202 35 - - HYPH cord-019051-gtruu1op 202 36 inactivated inactivate VBN cord-019051-gtruu1op 202 37 RSV RSV NNP cord-019051-gtruu1op 202 38 vaccine vaccine NN cord-019051-gtruu1op 202 39 in in IN cord-019051-gtruu1op 202 40 the the DT cord-019051-gtruu1op 202 41 1960s 1960 NNS cord-019051-gtruu1op 202 42 [ [ -LRB- cord-019051-gtruu1op 202 43 70 70 CD cord-019051-gtruu1op 202 44 ] ] -RRB- cord-019051-gtruu1op 202 45 [ [ -LRB- cord-019051-gtruu1op 202 46 71 71 CD cord-019051-gtruu1op 202 47 ] ] -RRB- cord-019051-gtruu1op 202 48 [ [ -LRB- cord-019051-gtruu1op 202 49 72 72 CD cord-019051-gtruu1op 202 50 ] ] -RRB- cord-019051-gtruu1op 202 51 . . . cord-019051-gtruu1op 203 1 This this DT cord-019051-gtruu1op 203 2 vaccine vaccine NN cord-019051-gtruu1op 203 3 was be VBD cord-019051-gtruu1op 203 4 poorly poorly RB cord-019051-gtruu1op 203 5 protective protective JJ cord-019051-gtruu1op 203 6 and and CC cord-019051-gtruu1op 203 7 vaccinated vaccinated JJ cord-019051-gtruu1op 203 8 children child NNS cord-019051-gtruu1op 203 9 and and CC cord-019051-gtruu1op 203 10 infants infant NNS cord-019051-gtruu1op 203 11 developed develop VBD cord-019051-gtruu1op 203 12 dramatically dramatically RB cord-019051-gtruu1op 203 13 enhanced enhance VBN cord-019051-gtruu1op 203 14 disease disease NN cord-019051-gtruu1op 203 15 compared compare VBN cord-019051-gtruu1op 203 16 to to IN cord-019051-gtruu1op 203 17 naive naive JJ cord-019051-gtruu1op 203 18 patients patient NNS cord-019051-gtruu1op 203 19 upon upon IN cord-019051-gtruu1op 203 20 natural natural JJ cord-019051-gtruu1op 203 21 RSV RSV NNP cord-019051-gtruu1op 203 22 reinfection reinfection NN cord-019051-gtruu1op 203 23 [ [ -LRB- cord-019051-gtruu1op 203 24 48 48 CD cord-019051-gtruu1op 203 25 ] ] -RRB- cord-019051-gtruu1op 203 26 . . . cord-019051-gtruu1op 204 1 Subsequent subsequent JJ cord-019051-gtruu1op 204 2 preclinical preclinical JJ cord-019051-gtruu1op 204 3 studies study NNS cord-019051-gtruu1op 204 4 confirmed confirm VBD cord-019051-gtruu1op 204 5 a a DT cord-019051-gtruu1op 204 6 bias bias NN cord-019051-gtruu1op 204 7 toward toward IN cord-019051-gtruu1op 204 8 a a DT cord-019051-gtruu1op 204 9 Th2-specific Th2-specific NNP cord-019051-gtruu1op 204 10 CD4 CD4 NNP cord-019051-gtruu1op 204 11 + + CC cord-019051-gtruu1op 204 12 T t NN cord-019051-gtruu1op 204 13 cell cell NN cord-019051-gtruu1op 204 14 response response NN cord-019051-gtruu1op 204 15 in in IN cord-019051-gtruu1op 204 16 animals animal NNS cord-019051-gtruu1op 204 17 treated treat VBN cord-019051-gtruu1op 204 18 with with IN cord-019051-gtruu1op 204 19 formalin formalin NN cord-019051-gtruu1op 204 20 - - HYPH cord-019051-gtruu1op 204 21 inactivated inactivate VBN cord-019051-gtruu1op 204 22 RSV RSV NNP cord-019051-gtruu1op 204 23 vaccine vaccine NN cord-019051-gtruu1op 204 24 vs vs IN cord-019051-gtruu1op 204 25 naturally naturally RB cord-019051-gtruu1op 204 26 infected infect VBN cord-019051-gtruu1op 204 27 animals animal NNS cord-019051-gtruu1op 204 28 [ [ -LRB- cord-019051-gtruu1op 204 29 73 73 CD cord-019051-gtruu1op 204 30 ] ] -RRB- cord-019051-gtruu1op 204 31 . . . cord-019051-gtruu1op 205 1 IL-4 IL-4 NNP cord-019051-gtruu1op 205 2 and and CC cord-019051-gtruu1op 205 3 IL-13 IL-13 NNP cord-019051-gtruu1op 205 4 support support NN cord-019051-gtruu1op 205 5 isotype isotype NN cord-019051-gtruu1op 205 6 switching switch VBG cord-019051-gtruu1op 205 7 to to IN cord-019051-gtruu1op 205 8 IgE IgE NNP cord-019051-gtruu1op 205 9 , , , cord-019051-gtruu1op 205 10 which which WDT cord-019051-gtruu1op 205 11 is be VBZ cord-019051-gtruu1op 205 12 bound bind VBN cord-019051-gtruu1op 205 13 to to TO cord-019051-gtruu1op 205 14 mast mast NN cord-019051-gtruu1op 205 15 cells cell NNS cord-019051-gtruu1op 205 16 and and CC cord-019051-gtruu1op 205 17 eosinophils eosinophil NNS cord-019051-gtruu1op 205 18 and and CC cord-019051-gtruu1op 205 19 , , , cord-019051-gtruu1op 205 20 upon upon IN cord-019051-gtruu1op 205 21 antigen antigen NN cord-019051-gtruu1op 205 22 contact contact NN cord-019051-gtruu1op 205 23 , , , cord-019051-gtruu1op 205 24 induces induce VBZ cord-019051-gtruu1op 205 25 release release NN cord-019051-gtruu1op 205 26 of of IN cord-019051-gtruu1op 205 27 inflammatory inflammatory JJ cord-019051-gtruu1op 205 28 mediators mediator NNS cord-019051-gtruu1op 205 29 like like IN cord-019051-gtruu1op 205 30 histamine histamine NN cord-019051-gtruu1op 205 31 or or CC cord-019051-gtruu1op 205 32 leukotrienes leukotriene NNS cord-019051-gtruu1op 205 33 by by IN cord-019051-gtruu1op 205 34 these these DT cord-019051-gtruu1op 205 35 cells cell NNS cord-019051-gtruu1op 205 36 . . . cord-019051-gtruu1op 206 1 These these DT cord-019051-gtruu1op 206 2 mediators mediator NNS cord-019051-gtruu1op 206 3 contribute contribute VBP cord-019051-gtruu1op 206 4 to to IN cord-019051-gtruu1op 206 5 the the DT cord-019051-gtruu1op 206 6 development development NN cord-019051-gtruu1op 206 7 of of IN cord-019051-gtruu1op 206 8 the the DT cord-019051-gtruu1op 206 9 typical typical JJ cord-019051-gtruu1op 206 10 clinical clinical JJ cord-019051-gtruu1op 206 11 symptoms symptom NNS cord-019051-gtruu1op 206 12 associated associate VBN cord-019051-gtruu1op 206 13 with with IN cord-019051-gtruu1op 206 14 RSV RSV NNP cord-019051-gtruu1op 206 15 disease disease NN cord-019051-gtruu1op 206 16 . . . cord-019051-gtruu1op 207 1 Several several JJ cord-019051-gtruu1op 207 2 viral viral JJ cord-019051-gtruu1op 207 3 proteins protein NNS cord-019051-gtruu1op 207 4 play play VBP cord-019051-gtruu1op 207 5 an an DT cord-019051-gtruu1op 207 6 important important JJ cord-019051-gtruu1op 207 7 role role NN cord-019051-gtruu1op 207 8 in in IN cord-019051-gtruu1op 207 9 the the DT cord-019051-gtruu1op 207 10 pathogenesis pathogenesis NN cord-019051-gtruu1op 207 11 of of IN cord-019051-gtruu1op 207 12 RSV RSV NNP cord-019051-gtruu1op 207 13 disease disease NN cord-019051-gtruu1op 207 14 ( ( -LRB- cord-019051-gtruu1op 207 15 reviewed review VBN cord-019051-gtruu1op 207 16 in in IN cord-019051-gtruu1op 207 17 [ [ -LRB- cord-019051-gtruu1op 207 18 44 44 CD cord-019051-gtruu1op 207 19 ] ] -RRB- cord-019051-gtruu1op 207 20 ) ) -RRB- cord-019051-gtruu1op 207 21 . . . cord-019051-gtruu1op 208 1 The the DT cord-019051-gtruu1op 208 2 soluble soluble JJ cord-019051-gtruu1op 208 3 G g NN cord-019051-gtruu1op 208 4 protein protein NN cord-019051-gtruu1op 208 5 has have VBZ cord-019051-gtruu1op 208 6 been be VBN cord-019051-gtruu1op 208 7 suggested suggest VBN cord-019051-gtruu1op 208 8 to to TO cord-019051-gtruu1op 208 9 modulate modulate VB cord-019051-gtruu1op 208 10 the the DT cord-019051-gtruu1op 208 11 innate innate JJ cord-019051-gtruu1op 208 12 immune immune JJ cord-019051-gtruu1op 208 13 response response NN cord-019051-gtruu1op 208 14 by by IN cord-019051-gtruu1op 208 15 down down IN cord-019051-gtruu1op 208 16 - - HYPH cord-019051-gtruu1op 208 17 regulating regulate VBG cord-019051-gtruu1op 208 18 inflammatory inflammatory JJ cord-019051-gtruu1op 208 19 mediators mediator NNS cord-019051-gtruu1op 208 20 such such JJ cord-019051-gtruu1op 208 21 as as IN cord-019051-gtruu1op 208 22 IL-6 IL-6 NNP cord-019051-gtruu1op 208 23 or or CC cord-019051-gtruu1op 208 24 IL-8 il-8 NN cord-019051-gtruu1op 208 25 in in IN cord-019051-gtruu1op 208 26 epithelial epithelial JJ cord-019051-gtruu1op 208 27 cells cell NNS cord-019051-gtruu1op 208 28 as as IN cord-019051-gtruu1op 208 29 a a DT cord-019051-gtruu1op 208 30 response response NN cord-019051-gtruu1op 208 31 to to IN cord-019051-gtruu1op 208 32 RSV RSV NNP cord-019051-gtruu1op 208 33 infection infection NN cord-019051-gtruu1op 208 34 [ [ -LRB- cord-019051-gtruu1op 208 35 74 74 CD cord-019051-gtruu1op 208 36 ] ] -RRB- cord-019051-gtruu1op 208 37 . . . cord-019051-gtruu1op 209 1 G g NN cord-019051-gtruu1op 209 2 protein protein NN cord-019051-gtruu1op 209 3 also also RB cord-019051-gtruu1op 209 4 modulates modulate VBZ cord-019051-gtruu1op 209 5 inflammatory inflammatory JJ cord-019051-gtruu1op 209 6 responses response NNS cord-019051-gtruu1op 209 7 of of IN cord-019051-gtruu1op 209 8 monocytes monocyte NNS cord-019051-gtruu1op 209 9 by by IN cord-019051-gtruu1op 209 10 acting act VBG cord-019051-gtruu1op 209 11 as as IN cord-019051-gtruu1op 209 12 a a DT cord-019051-gtruu1op 209 13 general general JJ cord-019051-gtruu1op 209 14 antagonist antagonist NN cord-019051-gtruu1op 209 15 for for IN cord-019051-gtruu1op 209 16 TLR TLR NNP cord-019051-gtruu1op 209 17 activity activity NN cord-019051-gtruu1op 209 18 [ [ -LRB- cord-019051-gtruu1op 209 19 75 75 CD cord-019051-gtruu1op 209 20 ] ] -RRB- cord-019051-gtruu1op 209 21 . . . cord-019051-gtruu1op 210 1 The the DT cord-019051-gtruu1op 210 2 G g NN cord-019051-gtruu1op 210 3 - - HYPH cord-019051-gtruu1op 210 4 mediated mediate VBN cord-019051-gtruu1op 210 5 suppression suppression NN cord-019051-gtruu1op 210 6 of of IN cord-019051-gtruu1op 210 7 TLR-4 TLR-4 NNP cord-019051-gtruu1op 210 8 signaling signaling NN cord-019051-gtruu1op 210 9 appears appear VBZ cord-019051-gtruu1op 210 10 to to TO cord-019051-gtruu1op 210 11 be be VB cord-019051-gtruu1op 210 12 counteracted counteract VBN cord-019051-gtruu1op 210 13 by by IN cord-019051-gtruu1op 210 14 the the DT cord-019051-gtruu1op 210 15 F F NNP cord-019051-gtruu1op 210 16 protein protein NN cord-019051-gtruu1op 210 17 , , , cord-019051-gtruu1op 210 18 which which WDT cord-019051-gtruu1op 210 19 has have VBZ cord-019051-gtruu1op 210 20 been be VBN cord-019051-gtruu1op 210 21 described describe VBN cord-019051-gtruu1op 210 22 to to TO cord-019051-gtruu1op 210 23 induce induce VB cord-019051-gtruu1op 210 24 signaling signal VBG cord-019051-gtruu1op 210 25 through through IN cord-019051-gtruu1op 210 26 this this DT cord-019051-gtruu1op 210 27 TLR TLR NNP cord-019051-gtruu1op 210 28 [ [ -LRB- cord-019051-gtruu1op 210 29 76 76 CD cord-019051-gtruu1op 210 30 ] ] -RRB- cord-019051-gtruu1op 210 31 , , , cord-019051-gtruu1op 210 32 although although IN cord-019051-gtruu1op 210 33 the the DT cord-019051-gtruu1op 210 34 significance significance NN cord-019051-gtruu1op 210 35 of of IN cord-019051-gtruu1op 210 36 this this DT cord-019051-gtruu1op 210 37 activity activity NN cord-019051-gtruu1op 210 38 is be VBZ cord-019051-gtruu1op 210 39 unclear unclear JJ cord-019051-gtruu1op 210 40 . . . cord-019051-gtruu1op 211 1 Importantly importantly RB cord-019051-gtruu1op 211 2 , , , cord-019051-gtruu1op 211 3 RSV RSV NNP cord-019051-gtruu1op 211 4 infection infection NN cord-019051-gtruu1op 211 5 can can MD cord-019051-gtruu1op 211 6 block block VB cord-019051-gtruu1op 211 7 the the DT cord-019051-gtruu1op 211 8 maturation maturation NN cord-019051-gtruu1op 211 9 of of IN cord-019051-gtruu1op 211 10 dendritic dendritic JJ cord-019051-gtruu1op 211 11 cells cell NNS cord-019051-gtruu1op 211 12 ( ( -LRB- cord-019051-gtruu1op 211 13 DC DC NNP cord-019051-gtruu1op 211 14 ) ) -RRB- cord-019051-gtruu1op 211 15 , , , cord-019051-gtruu1op 211 16 which which WDT cord-019051-gtruu1op 211 17 serve serve VBP cord-019051-gtruu1op 211 18 as as IN cord-019051-gtruu1op 211 19 major major JJ cord-019051-gtruu1op 211 20 antigen antigen NN cord-019051-gtruu1op 211 21 - - HYPH cord-019051-gtruu1op 211 22 presenting present VBG cord-019051-gtruu1op 211 23 cells cell NNS cord-019051-gtruu1op 211 24 ( ( -LRB- cord-019051-gtruu1op 211 25 reviewed review VBN cord-019051-gtruu1op 211 26 in in IN cord-019051-gtruu1op 211 27 [ [ -LRB- cord-019051-gtruu1op 211 28 44 44 CD cord-019051-gtruu1op 211 29 ] ] -RRB- cord-019051-gtruu1op 211 30 ) ) -RRB- cord-019051-gtruu1op 211 31 . . . cord-019051-gtruu1op 212 1 This this DT cord-019051-gtruu1op 212 2 alteration alteration NN cord-019051-gtruu1op 212 3 of of IN cord-019051-gtruu1op 212 4 DC DC NNP cord-019051-gtruu1op 212 5 biology biology NN cord-019051-gtruu1op 212 6 may may MD cord-019051-gtruu1op 212 7 support support VB cord-019051-gtruu1op 212 8 the the DT cord-019051-gtruu1op 212 9 shift shift NN cord-019051-gtruu1op 212 10 of of IN cord-019051-gtruu1op 212 11 the the DT cord-019051-gtruu1op 212 12 Th2 th2 CD cord-019051-gtruu1op 212 13 / / SYM cord-019051-gtruu1op 212 14 Th1 th1 CD cord-019051-gtruu1op 212 15 balance balance NN cord-019051-gtruu1op 212 16 towards towards IN cord-019051-gtruu1op 212 17 Th2 Th2 NNP cord-019051-gtruu1op 212 18 , , , cord-019051-gtruu1op 212 19 reduce reduce VB cord-019051-gtruu1op 212 20 antiviral antiviral JJ cord-019051-gtruu1op 212 21 interferon interferon NN cord-019051-gtruu1op 212 22 activity activity NN cord-019051-gtruu1op 212 23 and and CC cord-019051-gtruu1op 212 24 limit limit VB cord-019051-gtruu1op 212 25 the the DT cord-019051-gtruu1op 212 26 mobility mobility NN cord-019051-gtruu1op 212 27 of of IN cord-019051-gtruu1op 212 28 mature mature JJ cord-019051-gtruu1op 212 29 antigen antigen NN cord-019051-gtruu1op 212 30 - - HYPH cord-019051-gtruu1op 212 31 presenting present VBG cord-019051-gtruu1op 212 32 cells cell NNS cord-019051-gtruu1op 212 33 , , , cord-019051-gtruu1op 212 34 thus thus RB cord-019051-gtruu1op 212 35 qualitatively qualitatively RB cord-019051-gtruu1op 212 36 altering alter VBG cord-019051-gtruu1op 212 37 the the DT cord-019051-gtruu1op 212 38 immune immune JJ cord-019051-gtruu1op 212 39 response response NN cord-019051-gtruu1op 212 40 to to IN cord-019051-gtruu1op 212 41 RSV RSV NNP cord-019051-gtruu1op 212 42 infection infection NN cord-019051-gtruu1op 212 43 ( ( -LRB- cord-019051-gtruu1op 212 44 reviewed review VBN cord-019051-gtruu1op 212 45 in in IN cord-019051-gtruu1op 212 46 [ [ -LRB- cord-019051-gtruu1op 212 47 44 44 CD cord-019051-gtruu1op 212 48 ] ] -RRB- cord-019051-gtruu1op 212 49 ) ) -RRB- cord-019051-gtruu1op 212 50 . . . cord-019051-gtruu1op 213 1 In in IN cord-019051-gtruu1op 213 2 summary summary NN cord-019051-gtruu1op 213 3 , , , cord-019051-gtruu1op 213 4 there there EX cord-019051-gtruu1op 213 5 are be VBP cord-019051-gtruu1op 213 6 several several JJ cord-019051-gtruu1op 213 7 host host NN cord-019051-gtruu1op 213 8 factors factor NNS cord-019051-gtruu1op 213 9 or or CC cord-019051-gtruu1op 213 10 viral viral JJ cord-019051-gtruu1op 213 11 factors factor NNS cord-019051-gtruu1op 213 12 that that WDT cord-019051-gtruu1op 213 13 play play VBP cord-019051-gtruu1op 213 14 roles role NNS cord-019051-gtruu1op 213 15 in in IN cord-019051-gtruu1op 213 16 the the DT cord-019051-gtruu1op 213 17 pathogenesis pathogenesis NN cord-019051-gtruu1op 213 18 of of IN cord-019051-gtruu1op 213 19 RSV RSV NNP cord-019051-gtruu1op 213 20 infection infection NN cord-019051-gtruu1op 213 21 . . . cord-019051-gtruu1op 214 1 The the DT cord-019051-gtruu1op 214 2 picture picture NN cord-019051-gtruu1op 214 3 , , , cord-019051-gtruu1op 214 4 however however RB cord-019051-gtruu1op 214 5 , , , cord-019051-gtruu1op 214 6 is be VBZ cord-019051-gtruu1op 214 7 highly highly RB cord-019051-gtruu1op 214 8 complex complex JJ cord-019051-gtruu1op 214 9 and and CC cord-019051-gtruu1op 214 10 relative relative JJ cord-019051-gtruu1op 214 11 contributions contribution NNS cord-019051-gtruu1op 214 12 of of IN cord-019051-gtruu1op 214 13 the the DT cord-019051-gtruu1op 214 14 various various JJ cord-019051-gtruu1op 214 15 factors factor NNS cord-019051-gtruu1op 214 16 to to IN cord-019051-gtruu1op 214 17 RSV RSV NNP cord-019051-gtruu1op 214 18 pathogenesis pathogenesis NN cord-019051-gtruu1op 214 19 are be VBP cord-019051-gtruu1op 214 20 not not RB cord-019051-gtruu1op 214 21 entirely entirely RB cord-019051-gtruu1op 214 22 understood understand VBN cord-019051-gtruu1op 214 23 . . . cord-019051-gtruu1op 215 1 As as IN cord-019051-gtruu1op 215 2 mentioned mention VBN cord-019051-gtruu1op 215 3 above above IN cord-019051-gtruu1op 215 4 RSV RSV NNP cord-019051-gtruu1op 215 5 is be VBZ cord-019051-gtruu1op 215 6 a a DT cord-019051-gtruu1op 215 7 leading leading JJ cord-019051-gtruu1op 215 8 cause cause NN cord-019051-gtruu1op 215 9 of of IN cord-019051-gtruu1op 215 10 respiratory respiratory JJ cord-019051-gtruu1op 215 11 diseases disease NNS cord-019051-gtruu1op 215 12 in in IN cord-019051-gtruu1op 215 13 children child NNS cord-019051-gtruu1op 215 14 and and CC cord-019051-gtruu1op 215 15 has have VBZ cord-019051-gtruu1op 215 16 increasing increase VBG cord-019051-gtruu1op 215 17 importance importance NN cord-019051-gtruu1op 215 18 as as IN cord-019051-gtruu1op 215 19 a a DT cord-019051-gtruu1op 215 20 causative causative JJ cord-019051-gtruu1op 215 21 agent agent NN cord-019051-gtruu1op 215 22 for for IN cord-019051-gtruu1op 215 23 respiratory respiratory JJ cord-019051-gtruu1op 215 24 diseases disease NNS cord-019051-gtruu1op 215 25 in in IN cord-019051-gtruu1op 215 26 elderly elderly JJ cord-019051-gtruu1op 215 27 . . . cord-019051-gtruu1op 216 1 In in IN cord-019051-gtruu1op 216 2 a a DT cord-019051-gtruu1op 216 3 prospective prospective JJ cord-019051-gtruu1op 216 4 study study NN cord-019051-gtruu1op 216 5 of of IN cord-019051-gtruu1op 216 6 infants infant NNS cord-019051-gtruu1op 216 7 and and CC cord-019051-gtruu1op 216 8 children child NNS cord-019051-gtruu1op 216 9 in in IN cord-019051-gtruu1op 216 10 the the DT cord-019051-gtruu1op 216 11 Unites Unites NNPS cord-019051-gtruu1op 216 12 States States NNP cord-019051-gtruu1op 216 13 , , , cord-019051-gtruu1op 216 14 RSV RSV NNP cord-019051-gtruu1op 216 15 was be VBD cord-019051-gtruu1op 216 16 detected detect VBN cord-019051-gtruu1op 216 17 in in IN cord-019051-gtruu1op 216 18 43 43 CD cord-019051-gtruu1op 216 19 % % NN cord-019051-gtruu1op 216 20 of of IN cord-019051-gtruu1op 216 21 pediatric pediatric JJ cord-019051-gtruu1op 216 22 hospitalizations hospitalization NNS cord-019051-gtruu1op 216 23 for for IN cord-019051-gtruu1op 216 24 bronchiolitis bronchiolitis NN cord-019051-gtruu1op 216 25 , , , cord-019051-gtruu1op 216 26 25 25 CD cord-019051-gtruu1op 216 27 % % NN cord-019051-gtruu1op 216 28 for for IN cord-019051-gtruu1op 216 29 pneumonia pneumonia NN cord-019051-gtruu1op 216 30 , , , cord-019051-gtruu1op 216 31 11 11 CD cord-019051-gtruu1op 216 32 % % NN cord-019051-gtruu1op 216 33 for for IN cord-019051-gtruu1op 216 34 bronchitis bronchitis NN cord-019051-gtruu1op 216 35 and and CC cord-019051-gtruu1op 216 36 10 10 CD cord-019051-gtruu1op 216 37 % % NN cord-019051-gtruu1op 216 38 for for IN cord-019051-gtruu1op 216 39 croup croup NN cord-019051-gtruu1op 216 40 [ [ -LRB- cord-019051-gtruu1op 216 41 54 54 CD cord-019051-gtruu1op 216 42 ] ] -RRB- cord-019051-gtruu1op 216 43 . . . cord-019051-gtruu1op 217 1 Approximately approximately RB cord-019051-gtruu1op 217 2 90 90 CD cord-019051-gtruu1op 217 3 % % NN cord-019051-gtruu1op 217 4 of of IN cord-019051-gtruu1op 217 5 infants infant NNS cord-019051-gtruu1op 217 6 have have VBP cord-019051-gtruu1op 217 7 been be VBN cord-019051-gtruu1op 217 8 infected infect VBN cord-019051-gtruu1op 217 9 at at IN cord-019051-gtruu1op 217 10 least least JJS cord-019051-gtruu1op 217 11 once once RB cord-019051-gtruu1op 217 12 by by IN cord-019051-gtruu1op 217 13 2 2 CD cord-019051-gtruu1op 217 14 years year NNS cord-019051-gtruu1op 217 15 of of IN cord-019051-gtruu1op 217 16 age age NN cord-019051-gtruu1op 217 17 [ [ -LRB- cord-019051-gtruu1op 217 18 44 44 CD cord-019051-gtruu1op 217 19 , , , cord-019051-gtruu1op 217 20 77 77 CD cord-019051-gtruu1op 217 21 ] ] -RRB- cord-019051-gtruu1op 217 22 . . . cord-019051-gtruu1op 218 1 Although although IN cord-019051-gtruu1op 218 2 RSV RSV NNP cord-019051-gtruu1op 218 3 is be VBZ cord-019051-gtruu1op 218 4 represented represent VBN cord-019051-gtruu1op 218 5 by by IN cord-019051-gtruu1op 218 6 one one CD cord-019051-gtruu1op 218 7 serotype serotype NN cord-019051-gtruu1op 218 8 , , , cord-019051-gtruu1op 218 9 a a DT cord-019051-gtruu1op 218 10 protective protective JJ cord-019051-gtruu1op 218 11 immunity immunity NN cord-019051-gtruu1op 218 12 against against IN cord-019051-gtruu1op 218 13 RSV RSV NNP cord-019051-gtruu1op 218 14 is be VBZ cord-019051-gtruu1op 218 15 generally generally RB cord-019051-gtruu1op 218 16 weak weak JJ cord-019051-gtruu1op 218 17 and and CC cord-019051-gtruu1op 218 18 reinfection reinfection NN cord-019051-gtruu1op 218 19 occurs occur VBZ cord-019051-gtruu1op 218 20 . . . cord-019051-gtruu1op 219 1 Virus virus NN cord-019051-gtruu1op 219 2 - - HYPH cord-019051-gtruu1op 219 3 neutralizing neutralize VBG cord-019051-gtruu1op 219 4 antibodies antibody NNS cord-019051-gtruu1op 219 5 , , , cord-019051-gtruu1op 219 6 including include VBG cord-019051-gtruu1op 219 7 secretory secretory JJ cord-019051-gtruu1op 219 8 IgA IgA NNP cord-019051-gtruu1op 219 9 found find VBN cord-019051-gtruu1op 219 10 in in IN cord-019051-gtruu1op 219 11 the the DT cord-019051-gtruu1op 219 12 respiratory respiratory JJ cord-019051-gtruu1op 219 13 tract tract NN cord-019051-gtruu1op 219 14 , , , cord-019051-gtruu1op 219 15 contribute contribute VBP cord-019051-gtruu1op 219 16 to to IN cord-019051-gtruu1op 219 17 viral viral JJ cord-019051-gtruu1op 219 18 clearance clearance NN cord-019051-gtruu1op 219 19 and and CC cord-019051-gtruu1op 219 20 may may MD cord-019051-gtruu1op 219 21 play play VB cord-019051-gtruu1op 219 22 a a DT cord-019051-gtruu1op 219 23 role role NN cord-019051-gtruu1op 219 24 in in IN cord-019051-gtruu1op 219 25 protection protection NN cord-019051-gtruu1op 219 26 against against IN cord-019051-gtruu1op 219 27 reinfection reinfection NN cord-019051-gtruu1op 219 28 [ [ -LRB- cord-019051-gtruu1op 219 29 54 54 CD cord-019051-gtruu1op 219 30 ] ] -RRB- cord-019051-gtruu1op 219 31 . . . cord-019051-gtruu1op 220 1 However however RB cord-019051-gtruu1op 220 2 , , , cord-019051-gtruu1op 220 3 the the DT cord-019051-gtruu1op 220 4 IgA IgA NNP cord-019051-gtruu1op 220 5 response response NN cord-019051-gtruu1op 220 6 is be VBZ cord-019051-gtruu1op 220 7 short short JJ cord-019051-gtruu1op 220 8 [ [ -LRB- cord-019051-gtruu1op 220 9 44 44 CD cord-019051-gtruu1op 220 10 , , , cord-019051-gtruu1op 220 11 54 54 CD cord-019051-gtruu1op 220 12 ] ] -RRB- cord-019051-gtruu1op 220 13 . . . cord-019051-gtruu1op 221 1 In in IN cord-019051-gtruu1op 221 2 the the DT cord-019051-gtruu1op 221 3 lower low JJR cord-019051-gtruu1op 221 4 respiratory respiratory JJ cord-019051-gtruu1op 221 5 tract tract NN cord-019051-gtruu1op 221 6 , , , cord-019051-gtruu1op 221 7 the the DT cord-019051-gtruu1op 221 8 IgG IgG NNP cord-019051-gtruu1op 221 9 response response NN cord-019051-gtruu1op 221 10 has have VBZ cord-019051-gtruu1op 221 11 been be VBN cord-019051-gtruu1op 221 12 described describe VBN cord-019051-gtruu1op 221 13 as as IN cord-019051-gtruu1op 221 14 more more RBR cord-019051-gtruu1op 221 15 efficient efficient JJ cord-019051-gtruu1op 221 16 . . . cord-019051-gtruu1op 222 1 The the DT cord-019051-gtruu1op 222 2 role role NN cord-019051-gtruu1op 222 3 of of IN cord-019051-gtruu1op 222 4 antibodies antibody NNS cord-019051-gtruu1op 222 5 as as IN cord-019051-gtruu1op 222 6 a a DT cord-019051-gtruu1op 222 7 down down JJ cord-019051-gtruu1op 222 8 - - HYPH cord-019051-gtruu1op 222 9 modulator modulator NN cord-019051-gtruu1op 222 10 of of IN cord-019051-gtruu1op 222 11 clinical clinical JJ cord-019051-gtruu1op 222 12 symptoms symptom NNS cord-019051-gtruu1op 222 13 has have VBZ cord-019051-gtruu1op 222 14 been be VBN cord-019051-gtruu1op 222 15 confirmed confirm VBN cord-019051-gtruu1op 222 16 by by IN cord-019051-gtruu1op 222 17 the the DT cord-019051-gtruu1op 222 18 clinical clinical JJ cord-019051-gtruu1op 222 19 experience experience NN cord-019051-gtruu1op 222 20 with with IN cord-019051-gtruu1op 222 21 palivizumab palivizumab NNS cord-019051-gtruu1op 222 22 . . . cord-019051-gtruu1op 223 1 In in IN cord-019051-gtruu1op 223 2 temperate temperate JJ cord-019051-gtruu1op 223 3 regions region NNS cord-019051-gtruu1op 223 4 , , , cord-019051-gtruu1op 223 5 RSV RSV NNP cord-019051-gtruu1op 223 6 circulates circulate VBZ cord-019051-gtruu1op 223 7 quickly quickly RB cord-019051-gtruu1op 223 8 during during IN cord-019051-gtruu1op 223 9 winter winter NN cord-019051-gtruu1op 223 10 / / SYM cord-019051-gtruu1op 223 11 early early JJ cord-019051-gtruu1op 223 12 spring spring NN cord-019051-gtruu1op 223 13 , , , cord-019051-gtruu1op 223 14 but but CC cord-019051-gtruu1op 223 15 timing timing NN cord-019051-gtruu1op 223 16 varies vary VBZ cord-019051-gtruu1op 223 17 more more RBR cord-019051-gtruu1op 223 18 elsewhere elsewhere RB cord-019051-gtruu1op 223 19 . . . cord-019051-gtruu1op 224 1 Effective effective JJ cord-019051-gtruu1op 224 2 vaccines vaccine NNS cord-019051-gtruu1op 224 3 are be VBP cord-019051-gtruu1op 224 4 not not RB cord-019051-gtruu1op 224 5 available available JJ cord-019051-gtruu1op 224 6 and and CC cord-019051-gtruu1op 224 7 effective effective JJ cord-019051-gtruu1op 224 8 therapies therapy NNS cord-019051-gtruu1op 224 9 are be VBP cord-019051-gtruu1op 224 10 not not RB cord-019051-gtruu1op 224 11 available available JJ cord-019051-gtruu1op 224 12 . . . cord-019051-gtruu1op 225 1 However however RB cord-019051-gtruu1op 225 2 , , , cord-019051-gtruu1op 225 3 an an DT cord-019051-gtruu1op 225 4 RSV RSV NNP cord-019051-gtruu1op 225 5 - - HYPH cord-019051-gtruu1op 225 6 neutralizing neutralize VBG cord-019051-gtruu1op 225 7 human human JJ cord-019051-gtruu1op 225 8 - - HYPH cord-019051-gtruu1op 225 9 ized ize VBN cord-019051-gtruu1op 225 10 monoclonal monoclonal JJ cord-019051-gtruu1op 225 11 antibody antibody NN cord-019051-gtruu1op 225 12 , , , cord-019051-gtruu1op 225 13 palivizumab palivizumab NNP cord-019051-gtruu1op 225 14 , , , cord-019051-gtruu1op 225 15 reduces reduce VBZ cord-019051-gtruu1op 225 16 RSV RSV NNP cord-019051-gtruu1op 225 17 - - HYPH cord-019051-gtruu1op 225 18 associated associate VBN cord-019051-gtruu1op 225 19 hospitalization hospitalization NN cord-019051-gtruu1op 225 20 if if IN cord-019051-gtruu1op 225 21 used use VBN cord-019051-gtruu1op 225 22 as as IN cord-019051-gtruu1op 225 23 a a DT cord-019051-gtruu1op 225 24 passive passive JJ cord-019051-gtruu1op 225 25 immunoprophylaxis immunoprophylaxis NN cord-019051-gtruu1op 225 26 [ [ -LRB- cord-019051-gtruu1op 225 27 78 78 CD cord-019051-gtruu1op 225 28 ] ] -RRB- cord-019051-gtruu1op 225 29 . . . cord-019051-gtruu1op 226 1 RSV RSV NNP cord-019051-gtruu1op 226 2 infection infection NN cord-019051-gtruu1op 226 3 is be VBZ cord-019051-gtruu1op 226 4 assumed assume VBN cord-019051-gtruu1op 226 5 to to TO cord-019051-gtruu1op 226 6 be be VB cord-019051-gtruu1op 226 7 frequently frequently RB cord-019051-gtruu1op 226 8 misdiagnosed misdiagnose VBN cord-019051-gtruu1op 226 9 , , , cord-019051-gtruu1op 226 10 particularly particularly RB cord-019051-gtruu1op 226 11 in in IN cord-019051-gtruu1op 226 12 adults adult NNS cord-019051-gtruu1op 226 13 [ [ -LRB- cord-019051-gtruu1op 226 14 56 56 CD cord-019051-gtruu1op 226 15 ] ] -RRB- cord-019051-gtruu1op 226 16 , , , cord-019051-gtruu1op 226 17 because because IN cord-019051-gtruu1op 226 18 the the DT cord-019051-gtruu1op 226 19 symptoms symptom NNS cord-019051-gtruu1op 226 20 are be VBP cord-019051-gtruu1op 226 21 similar similar JJ cord-019051-gtruu1op 226 22 to to IN cord-019051-gtruu1op 226 23 those those DT cord-019051-gtruu1op 226 24 caused cause VBN cord-019051-gtruu1op 226 25 by by IN cord-019051-gtruu1op 226 26 other other JJ cord-019051-gtruu1op 226 27 respiratory respiratory JJ cord-019051-gtruu1op 226 28 viruses virus NNS cord-019051-gtruu1op 226 29 like like IN cord-019051-gtruu1op 226 30 influenza influenza NN cord-019051-gtruu1op 226 31 . . . cord-019051-gtruu1op 227 1 Laboratory laboratory NN cord-019051-gtruu1op 227 2 diagnostic diagnostic JJ cord-019051-gtruu1op 227 3 tests test NNS cord-019051-gtruu1op 227 4 are be VBP cord-019051-gtruu1op 227 5 usually usually RB cord-019051-gtruu1op 227 6 performed perform VBN cord-019051-gtruu1op 227 7 on on IN cord-019051-gtruu1op 227 8 secretion secretion NN cord-019051-gtruu1op 227 9 samples sample NNS cord-019051-gtruu1op 227 10 obtained obtain VBN cord-019051-gtruu1op 227 11 from from IN cord-019051-gtruu1op 227 12 the the DT cord-019051-gtruu1op 227 13 nasopharynx nasopharynx NN cord-019051-gtruu1op 227 14 . . . cord-019051-gtruu1op 228 1 Novel novel JJ cord-019051-gtruu1op 228 2 rapid rapid JJ cord-019051-gtruu1op 228 3 ELISA ELISA NNP cord-019051-gtruu1op 228 4 - - HYPH cord-019051-gtruu1op 228 5 based base VBN cord-019051-gtruu1op 228 6 or or CC cord-019051-gtruu1op 228 7 RT RT NNP cord-019051-gtruu1op 228 8 - - HYPH cord-019051-gtruu1op 228 9 PCR PCR NNP cord-019051-gtruu1op 228 10 - - HYPH cord-019051-gtruu1op 228 11 based base VBN cord-019051-gtruu1op 228 12 tests test NNS cord-019051-gtruu1op 228 13 are be VBP cord-019051-gtruu1op 228 14 useful useful JJ cord-019051-gtruu1op 228 15 particularly particularly RB cord-019051-gtruu1op 228 16 in in IN cord-019051-gtruu1op 228 17 a a DT cord-019051-gtruu1op 228 18 hospital hospital NN cord-019051-gtruu1op 228 19 setting set VBG cord-019051-gtruu1op 228 20 to to TO cord-019051-gtruu1op 228 21 identify identify VB cord-019051-gtruu1op 228 22 outbreaks outbreak NNS cord-019051-gtruu1op 228 23 , , , cord-019051-gtruu1op 228 24 prevent prevent VB cord-019051-gtruu1op 228 25 further further JJ cord-019051-gtruu1op 228 26 transmission transmission NN cord-019051-gtruu1op 228 27 , , , cord-019051-gtruu1op 228 28 initiate initiate VB cord-019051-gtruu1op 228 29 therapies therapy NNS cord-019051-gtruu1op 228 30 or or CC cord-019051-gtruu1op 228 31 reduce reduce VB cord-019051-gtruu1op 228 32 inappropriate inappropriate JJ cord-019051-gtruu1op 228 33 use use NN cord-019051-gtruu1op 228 34 of of IN cord-019051-gtruu1op 228 35 antibiotics antibiotic NNS cord-019051-gtruu1op 228 36 [ [ -LRB- cord-019051-gtruu1op 228 37 56 56 CD cord-019051-gtruu1op 228 38 ] ] -RRB- cord-019051-gtruu1op 228 39 . . . cord-019051-gtruu1op 229 1 Animal animal NN cord-019051-gtruu1op 229 2 models model NNS cord-019051-gtruu1op 229 3 are be VBP cord-019051-gtruu1op 229 4 comprehensively comprehensively RB cord-019051-gtruu1op 229 5 reviewed review VBN cord-019051-gtruu1op 229 6 by by IN cord-019051-gtruu1op 229 7 Moore Moore NNP cord-019051-gtruu1op 229 8 and and CC cord-019051-gtruu1op 229 9 Stokes Stokes NNP cord-019051-gtruu1op 229 10 Peebles Peebles NNP cord-019051-gtruu1op 229 11 [ [ -LRB- cord-019051-gtruu1op 229 12 79 79 CD cord-019051-gtruu1op 229 13 ] ] -RRB- cord-019051-gtruu1op 229 14 . . . cord-019051-gtruu1op 230 1 RSV RSV NNP cord-019051-gtruu1op 230 2 is be VBZ cord-019051-gtruu1op 230 3 species specie NNS cord-019051-gtruu1op 230 4 specific specific JJ cord-019051-gtruu1op 230 5 ; ; : cord-019051-gtruu1op 230 6 however however RB cord-019051-gtruu1op 230 7 , , , cord-019051-gtruu1op 230 8 some some DT cord-019051-gtruu1op 230 9 animal animal NN cord-019051-gtruu1op 230 10 species specie NNS cord-019051-gtruu1op 230 11 exhibit exhibit VBP cord-019051-gtruu1op 230 12 semipermissive semipermissive JJ cord-019051-gtruu1op 230 13 infection infection NN cord-019051-gtruu1op 230 14 with with IN cord-019051-gtruu1op 230 15 RSV RSV NNP cord-019051-gtruu1op 230 16 . . . cord-019051-gtruu1op 231 1 Chimpanzees chimpanzee NNS cord-019051-gtruu1op 231 2 were be VBD cord-019051-gtruu1op 231 3 productively productively RB cord-019051-gtruu1op 231 4 infected infect VBN cord-019051-gtruu1op 231 5 with with IN cord-019051-gtruu1op 231 6 RSV RSV NNP cord-019051-gtruu1op 231 7 and and CC cord-019051-gtruu1op 231 8 exhibited exhibit VBD cord-019051-gtruu1op 231 9 upper upper JJ cord-019051-gtruu1op 231 10 respiratory respiratory JJ cord-019051-gtruu1op 231 11 tract tract NN cord-019051-gtruu1op 231 12 illness illness NN cord-019051-gtruu1op 231 13 , , , cord-019051-gtruu1op 231 14 whereas whereas IN cord-019051-gtruu1op 231 15 adult adult NN cord-019051-gtruu1op 231 16 squirrel squirrel NN cord-019051-gtruu1op 231 17 monkeys monkey NNS cord-019051-gtruu1op 231 18 , , , cord-019051-gtruu1op 231 19 newborn newborn JJ cord-019051-gtruu1op 231 20 rhesus rhesus NN cord-019051-gtruu1op 231 21 monkeys monkey NNS cord-019051-gtruu1op 231 22 , , , cord-019051-gtruu1op 231 23 and and CC cord-019051-gtruu1op 231 24 infant infant NN cord-019051-gtruu1op 231 25 cebus cebus NNP cord-019051-gtruu1op 231 26 monkeys monkey NNS cord-019051-gtruu1op 231 27 did do VBD cord-019051-gtruu1op 231 28 not not RB cord-019051-gtruu1op 231 29 show show VB cord-019051-gtruu1op 231 30 symptoms symptom NNS cord-019051-gtruu1op 231 31 but but CC cord-019051-gtruu1op 231 32 shed shed VB cord-019051-gtruu1op 231 33 low low JJ cord-019051-gtruu1op 231 34 levels level NNS cord-019051-gtruu1op 231 35 of of IN cord-019051-gtruu1op 231 36 virus virus NN cord-019051-gtruu1op 231 37 [ [ -LRB- cord-019051-gtruu1op 231 38 80 80 CD cord-019051-gtruu1op 231 39 ] ] -RRB- cord-019051-gtruu1op 231 40 . . . cord-019051-gtruu1op 232 1 Bonnet bonnet NN cord-019051-gtruu1op 232 2 monkeys monkey NNS cord-019051-gtruu1op 232 3 , , , cord-019051-gtruu1op 232 4 which which WDT cord-019051-gtruu1op 232 5 are be VBP cord-019051-gtruu1op 232 6 more more RBR cord-019051-gtruu1op 232 7 widely widely RB cord-019051-gtruu1op 232 8 available available JJ cord-019051-gtruu1op 232 9 than than IN cord-019051-gtruu1op 232 10 chimpanzees chimpanzee NNS cord-019051-gtruu1op 232 11 , , , cord-019051-gtruu1op 232 12 can can MD cord-019051-gtruu1op 232 13 be be VB cord-019051-gtruu1op 232 14 infected infect VBN cord-019051-gtruu1op 232 15 with with IN cord-019051-gtruu1op 232 16 RSV RSV NNP cord-019051-gtruu1op 232 17 [ [ -LRB- cord-019051-gtruu1op 232 18 81 81 CD cord-019051-gtruu1op 232 19 ] ] -RRB- cord-019051-gtruu1op 232 20 . . . cord-019051-gtruu1op 233 1 Non non JJ cord-019051-gtruu1op 233 2 - - JJ cord-019051-gtruu1op 233 3 human human JJ cord-019051-gtruu1op 233 4 primate primate JJ cord-019051-gtruu1op 233 5 models model NNS cord-019051-gtruu1op 233 6 of of IN cord-019051-gtruu1op 233 7 RSV RSV NNP cord-019051-gtruu1op 233 8 infection infection NN cord-019051-gtruu1op 233 9 , , , cord-019051-gtruu1op 233 10 especially especially RB cord-019051-gtruu1op 233 11 chimpanzee chimpanzee NN cord-019051-gtruu1op 233 12 , , , cord-019051-gtruu1op 233 13 have have VBP cord-019051-gtruu1op 233 14 advantages advantage NNS cord-019051-gtruu1op 233 15 but but CC cord-019051-gtruu1op 233 16 certainly certainly RB cord-019051-gtruu1op 233 17 limitations limitation NNS cord-019051-gtruu1op 233 18 associated associate VBN cord-019051-gtruu1op 233 19 with with IN cord-019051-gtruu1op 233 20 the the DT cord-019051-gtruu1op 233 21 high high JJ cord-019051-gtruu1op 233 22 cost cost NN cord-019051-gtruu1op 233 23 and and CC cord-019051-gtruu1op 233 24 genetic genetic JJ cord-019051-gtruu1op 233 25 variability variability NN cord-019051-gtruu1op 233 26 , , , cord-019051-gtruu1op 233 27 which which WDT cord-019051-gtruu1op 233 28 limits limit VBZ cord-019051-gtruu1op 233 29 the the DT cord-019051-gtruu1op 233 30 reproducibility reproducibility NN cord-019051-gtruu1op 233 31 of of IN cord-019051-gtruu1op 233 32 results result NNS cord-019051-gtruu1op 233 33 . . . cord-019051-gtruu1op 234 1 The the DT cord-019051-gtruu1op 234 2 cotton cotton NN cord-019051-gtruu1op 234 3 rat rat NN cord-019051-gtruu1op 234 4 which which WDT cord-019051-gtruu1op 234 5 is be VBZ cord-019051-gtruu1op 234 6 susceptible susceptible JJ cord-019051-gtruu1op 234 7 to to IN cord-019051-gtruu1op 234 8 both both DT cord-019051-gtruu1op 234 9 URTI URTI NNP cord-019051-gtruu1op 234 10 and and CC cord-019051-gtruu1op 234 11 LRTI LRTI NNP cord-019051-gtruu1op 234 12 with with IN cord-019051-gtruu1op 234 13 RSV RSV NNP cord-019051-gtruu1op 234 14 is be VBZ cord-019051-gtruu1op 234 15 seen see VBN cord-019051-gtruu1op 234 16 as as IN cord-019051-gtruu1op 234 17 one one CD cord-019051-gtruu1op 234 18 of of IN cord-019051-gtruu1op 234 19 the the DT cord-019051-gtruu1op 234 20 best good JJS cord-019051-gtruu1op 234 21 animal animal NN cord-019051-gtruu1op 234 22 models model NNS cord-019051-gtruu1op 234 23 of of IN cord-019051-gtruu1op 234 24 RSV RSV NNP cord-019051-gtruu1op 234 25 infection infection NN cord-019051-gtruu1op 234 26 and and CC cord-019051-gtruu1op 234 27 disease disease NN cord-019051-gtruu1op 234 28 [ [ -LRB- cord-019051-gtruu1op 234 29 79 79 CD cord-019051-gtruu1op 234 30 , , , cord-019051-gtruu1op 234 31 82 82 CD cord-019051-gtruu1op 234 32 ] ] -RRB- cord-019051-gtruu1op 234 33 . . . cord-019051-gtruu1op 235 1 In in IN cord-019051-gtruu1op 235 2 these these DT cord-019051-gtruu1op 235 3 animals animal NNS cord-019051-gtruu1op 235 4 , , , cord-019051-gtruu1op 235 5 RSV RSV NNP cord-019051-gtruu1op 235 6 infection infection NN cord-019051-gtruu1op 235 7 led lead VBD cord-019051-gtruu1op 235 8 to to IN cord-019051-gtruu1op 235 9 histologically histologically RB cord-019051-gtruu1op 235 10 confirmed confirm VBN cord-019051-gtruu1op 235 11 proliferative proliferative JJ cord-019051-gtruu1op 235 12 rhinitis rhinitis NN cord-019051-gtruu1op 235 13 , , , cord-019051-gtruu1op 235 14 bronchiolitis bronchiolitis NN cord-019051-gtruu1op 235 15 , , , cord-019051-gtruu1op 235 16 and and CC cord-019051-gtruu1op 235 17 the the DT cord-019051-gtruu1op 235 18 pulmonary pulmonary JJ cord-019051-gtruu1op 235 19 infiltration infiltration NN cord-019051-gtruu1op 235 20 of of IN cord-019051-gtruu1op 235 21 lymphocytes lymphocyte NNS cord-019051-gtruu1op 235 22 and and CC cord-019051-gtruu1op 235 23 neutrophils neutrophil NNS cord-019051-gtruu1op 235 24 [ [ -LRB- cord-019051-gtruu1op 235 25 82 82 CD cord-019051-gtruu1op 235 26 ] ] -RRB- cord-019051-gtruu1op 236 1 [ [ -LRB- cord-019051-gtruu1op 236 2 83 83 CD cord-019051-gtruu1op 236 3 ] ] -RRB- cord-019051-gtruu1op 236 4 [ [ -LRB- cord-019051-gtruu1op 236 5 84 84 CD cord-019051-gtruu1op 236 6 ] ] -RRB- cord-019051-gtruu1op 236 7 . . . cord-019051-gtruu1op 237 1 The the DT cord-019051-gtruu1op 237 2 cotton cotton NN cord-019051-gtruu1op 237 3 rat rat NN cord-019051-gtruu1op 237 4 model model NN cord-019051-gtruu1op 237 5 was be VBD cord-019051-gtruu1op 237 6 used use VBN cord-019051-gtruu1op 237 7 to to TO cord-019051-gtruu1op 237 8 study study VB cord-019051-gtruu1op 237 9 the the DT cord-019051-gtruu1op 237 10 mechanism mechanism NN cord-019051-gtruu1op 237 11 of of IN cord-019051-gtruu1op 237 12 antibody antibody NN cord-019051-gtruu1op 237 13 - - HYPH cord-019051-gtruu1op 237 14 mediated mediate VBN cord-019051-gtruu1op 237 15 clearance clearance NN cord-019051-gtruu1op 237 16 of of IN cord-019051-gtruu1op 237 17 RSV RSV NNP cord-019051-gtruu1op 237 18 [ [ -LRB- cord-019051-gtruu1op 237 19 84 84 CD cord-019051-gtruu1op 237 20 ] ] -RRB- cord-019051-gtruu1op 237 21 . . . cord-019051-gtruu1op 238 1 The the DT cord-019051-gtruu1op 238 2 advantages advantage NNS cord-019051-gtruu1op 238 3 of of IN cord-019051-gtruu1op 238 4 mouse mouse NN cord-019051-gtruu1op 238 5 models model NNS cord-019051-gtruu1op 238 6 are be VBP cord-019051-gtruu1op 238 7 obvious obvious JJ cord-019051-gtruu1op 238 8 : : : cord-019051-gtruu1op 238 9 they -PRON- PRP cord-019051-gtruu1op 238 10 are be VBP cord-019051-gtruu1op 238 11 inexpensive inexpensive JJ cord-019051-gtruu1op 238 12 , , , cord-019051-gtruu1op 238 13 inbred inbred JJ cord-019051-gtruu1op 238 14 strains strain NNS cord-019051-gtruu1op 238 15 are be VBP cord-019051-gtruu1op 238 16 available available JJ cord-019051-gtruu1op 238 17 and and CC cord-019051-gtruu1op 238 18 a a DT cord-019051-gtruu1op 238 19 wealth wealth NN cord-019051-gtruu1op 238 20 of of IN cord-019051-gtruu1op 238 21 reagents reagent NNS cord-019051-gtruu1op 238 22 ( ( -LRB- cord-019051-gtruu1op 238 23 e.g. e.g. RB cord-019051-gtruu1op 238 24 , , , cord-019051-gtruu1op 238 25 antibodies antibody NNS cord-019051-gtruu1op 238 26 ) ) -RRB- cord-019051-gtruu1op 238 27 , , , cord-019051-gtruu1op 238 28 arrays array NNS cord-019051-gtruu1op 238 29 , , , cord-019051-gtruu1op 238 30 probes probe NNS cord-019051-gtruu1op 238 31 or or CC cord-019051-gtruu1op 238 32 information information NN cord-019051-gtruu1op 238 33 ( ( -LRB- cord-019051-gtruu1op 238 34 e.g. e.g. RB cord-019051-gtruu1op 238 35 , , , cord-019051-gtruu1op 238 36 the the DT cord-019051-gtruu1op 238 37 genome genome NN cord-019051-gtruu1op 238 38 sequence sequence NN cord-019051-gtruu1op 238 39 ) ) -RRB- cord-019051-gtruu1op 238 40 is be VBZ cord-019051-gtruu1op 238 41 available available JJ cord-019051-gtruu1op 238 42 . . . cord-019051-gtruu1op 239 1 Although although IN cord-019051-gtruu1op 239 2 there there EX cord-019051-gtruu1op 239 3 is be VBZ cord-019051-gtruu1op 239 4 variability variability NN cord-019051-gtruu1op 239 5 between between IN cord-019051-gtruu1op 239 6 the the DT cord-019051-gtruu1op 239 7 strains strain NNS cord-019051-gtruu1op 239 8 regarding regard VBG cord-019051-gtruu1op 239 9 susceptibility susceptibility NN cord-019051-gtruu1op 239 10 and and CC cord-019051-gtruu1op 239 11 viral viral JJ cord-019051-gtruu1op 239 12 load load NN cord-019051-gtruu1op 239 13 , , , cord-019051-gtruu1op 239 14 viral viral JJ cord-019051-gtruu1op 239 15 load load NN cord-019051-gtruu1op 239 16 does do VBZ cord-019051-gtruu1op 239 17 not not RB cord-019051-gtruu1op 239 18 vary vary VB cord-019051-gtruu1op 239 19 much much RB cord-019051-gtruu1op 239 20 within within IN cord-019051-gtruu1op 239 21 the the DT cord-019051-gtruu1op 239 22 strains strain NNS cord-019051-gtruu1op 239 23 [ [ -LRB- cord-019051-gtruu1op 239 24 79 79 CD cord-019051-gtruu1op 239 25 ] ] -RRB- cord-019051-gtruu1op 239 26 . . . cord-019051-gtruu1op 240 1 BALB BALB NNP cord-019051-gtruu1op 240 2 / / SYM cord-019051-gtruu1op 240 3 c c NNP cord-019051-gtruu1op 240 4 is be VBZ cord-019051-gtruu1op 240 5 the the DT cord-019051-gtruu1op 240 6 most most RBS cord-019051-gtruu1op 240 7 widely widely RB cord-019051-gtruu1op 240 8 used use VBN cord-019051-gtruu1op 240 9 inbred inbred JJ cord-019051-gtruu1op 240 10 mouse mouse NN cord-019051-gtruu1op 240 11 strain strain NN cord-019051-gtruu1op 240 12 to to TO cord-019051-gtruu1op 240 13 study study VB cord-019051-gtruu1op 240 14 RSV RSV NNP cord-019051-gtruu1op 240 15 infection infection NN cord-019051-gtruu1op 240 16 [ [ -LRB- cord-019051-gtruu1op 240 17 79 79 CD cord-019051-gtruu1op 240 18 ] ] -RRB- cord-019051-gtruu1op 240 19 . . . cord-019051-gtruu1op 241 1 RSV RSV NNP cord-019051-gtruu1op 241 2 - - HYPH cord-019051-gtruu1op 241 3 infected infect VBN cord-019051-gtruu1op 241 4 BALB BALB NNP cord-019051-gtruu1op 241 5 / / SYM cord-019051-gtruu1op 241 6 c c NN cord-019051-gtruu1op 241 7 mice mouse NNS cord-019051-gtruu1op 241 8 show show VBP cord-019051-gtruu1op 241 9 signs sign NNS cord-019051-gtruu1op 241 10 of of IN cord-019051-gtruu1op 241 11 clinical clinical JJ cord-019051-gtruu1op 241 12 illness illness NN cord-019051-gtruu1op 241 13 including include VBG cord-019051-gtruu1op 241 14 weight weight NN cord-019051-gtruu1op 241 15 loss loss NN cord-019051-gtruu1op 241 16 , , , cord-019051-gtruu1op 241 17 ruffled ruffled JJ cord-019051-gtruu1op 241 18 fur fur NN cord-019051-gtruu1op 241 19 and and CC cord-019051-gtruu1op 241 20 ataxia ataxia NN cord-019051-gtruu1op 241 21 peaking peak VBG cord-019051-gtruu1op 241 22 at at IN cord-019051-gtruu1op 241 23 day day NN cord-019051-gtruu1op 241 24 8 8 CD cord-019051-gtruu1op 241 25 after after IN cord-019051-gtruu1op 241 26 infection infection NN cord-019051-gtruu1op 241 27 [ [ -LRB- cord-019051-gtruu1op 241 28 85 85 CD cord-019051-gtruu1op 241 29 ] ] -RRB- cord-019051-gtruu1op 241 30 . . . cord-019051-gtruu1op 242 1 Interestingly interestingly RB cord-019051-gtruu1op 242 2 , , , cord-019051-gtruu1op 242 3 the the DT cord-019051-gtruu1op 242 4 susceptibility susceptibility NN cord-019051-gtruu1op 242 5 to to IN cord-019051-gtruu1op 242 6 RSV RSV NNP cord-019051-gtruu1op 242 7 replication replication NN cord-019051-gtruu1op 242 8 in in IN cord-019051-gtruu1op 242 9 nose nose NN cord-019051-gtruu1op 242 10 and and CC cord-019051-gtruu1op 242 11 lung lung NN cord-019051-gtruu1op 242 12 increased increase VBD cord-019051-gtruu1op 242 13 with with IN cord-019051-gtruu1op 242 14 age age NN cord-019051-gtruu1op 242 15 . . . cord-019051-gtruu1op 243 1 The the DT cord-019051-gtruu1op 243 2 predominant predominant JJ cord-019051-gtruu1op 243 3 histological histological JJ cord-019051-gtruu1op 243 4 findings finding NNS cord-019051-gtruu1op 243 5 in in IN cord-019051-gtruu1op 243 6 RSV RSV NNP cord-019051-gtruu1op 243 7 - - HYPH cord-019051-gtruu1op 243 8 infected infect VBN cord-019051-gtruu1op 243 9 3-week 3-week JJ cord-019051-gtruu1op 243 10 - - HYPH cord-019051-gtruu1op 243 11 old old JJ cord-019051-gtruu1op 243 12 BALB BALB NNP cord-019051-gtruu1op 243 13 / / SYM cord-019051-gtruu1op 243 14 c c NN cord-019051-gtruu1op 243 15 mice mouse NNS cord-019051-gtruu1op 243 16 were be VBD cord-019051-gtruu1op 243 17 peribronchiolar peribronchiolar JJ cord-019051-gtruu1op 243 18 and and CC cord-019051-gtruu1op 243 19 perivascular perivascular JJ cord-019051-gtruu1op 243 20 accumulations accumulation NNS cord-019051-gtruu1op 243 21 of of IN cord-019051-gtruu1op 243 22 mononuclear mononuclear JJ cord-019051-gtruu1op 243 23 cells cell NNS cord-019051-gtruu1op 243 24 [ [ -LRB- cord-019051-gtruu1op 243 25 86 86 CD cord-019051-gtruu1op 243 26 ] ] -RRB- cord-019051-gtruu1op 243 27 . . . cord-019051-gtruu1op 244 1 The the DT cord-019051-gtruu1op 244 2 role role NN cord-019051-gtruu1op 244 3 of of IN cord-019051-gtruu1op 244 4 Th1 th1 NN cord-019051-gtruu1op 244 5 and and CC cord-019051-gtruu1op 244 6 Th2 Th2 NNP cord-019051-gtruu1op 244 7 cell cell NN cord-019051-gtruu1op 244 8 response response NN cord-019051-gtruu1op 244 9 to to IN cord-019051-gtruu1op 244 10 RSV RSV NNP cord-019051-gtruu1op 244 11 infection infection NN cord-019051-gtruu1op 244 12 has have VBZ cord-019051-gtruu1op 244 13 been be VBN cord-019051-gtruu1op 244 14 the the DT cord-019051-gtruu1op 244 15 dominant dominant JJ cord-019051-gtruu1op 244 16 focus focus NN cord-019051-gtruu1op 244 17 of of IN cord-019051-gtruu1op 244 18 the the DT cord-019051-gtruu1op 244 19 BALB BALB NNP cord-019051-gtruu1op 244 20 / / SYM cord-019051-gtruu1op 244 21 c c NNP cord-019051-gtruu1op 244 22 mouse mouse NN cord-019051-gtruu1op 244 23 studies study NNS cord-019051-gtruu1op 244 24 in in IN cord-019051-gtruu1op 244 25 this this DT cord-019051-gtruu1op 244 26 context context NN cord-019051-gtruu1op 244 27 [ [ -LRB- cord-019051-gtruu1op 244 28 79 79 CD cord-019051-gtruu1op 244 29 ] ] -RRB- cord-019051-gtruu1op 244 30 . . . cord-019051-gtruu1op 245 1 RSV RSV NNP cord-019051-gtruu1op 245 2 infection infection NN cord-019051-gtruu1op 245 3 induces induce VBZ cord-019051-gtruu1op 245 4 a a DT cord-019051-gtruu1op 245 5 Th1 th1 CD cord-019051-gtruu1op 245 6 response response NN cord-019051-gtruu1op 245 7 dominated dominate VBN cord-019051-gtruu1op 245 8 by by IN cord-019051-gtruu1op 245 9 high high JJ cord-019051-gtruu1op 245 10 IFN IFN NNP cord-019051-gtruu1op 245 11 - - HYPH cord-019051-gtruu1op 245 12 levels level NNS cord-019051-gtruu1op 245 13 in in IN cord-019051-gtruu1op 245 14 the the DT cord-019051-gtruu1op 245 15 lungs lung NNS cord-019051-gtruu1op 245 16 of of IN cord-019051-gtruu1op 245 17 infected infected JJ cord-019051-gtruu1op 245 18 mice mouse NNS cord-019051-gtruu1op 245 19 , , , cord-019051-gtruu1op 245 20 abundant abundant JJ cord-019051-gtruu1op 245 21 IFN IFN NNP cord-019051-gtruu1op 245 22 -- -- : cord-019051-gtruu1op 245 23 producing produce VBG cord-019051-gtruu1op 245 24 cells cell NNS cord-019051-gtruu1op 245 25 in in IN cord-019051-gtruu1op 245 26 the the DT cord-019051-gtruu1op 245 27 bronchoalveo bronchoalveo NNP cord-019051-gtruu1op 245 28 - - HYPH cord-019051-gtruu1op 245 29 lar lar JJ cord-019051-gtruu1op 245 30 lavage lavage NN cord-019051-gtruu1op 245 31 fluid fluid NN cord-019051-gtruu1op 245 32 ( ( -LRB- cord-019051-gtruu1op 245 33 BALF BALF NNP cord-019051-gtruu1op 245 34 ) ) -RRB- cord-019051-gtruu1op 245 35 and and CC cord-019051-gtruu1op 245 36 RSV RSV NNP cord-019051-gtruu1op 245 37 - - HYPH cord-019051-gtruu1op 245 38 specific specific JJ cord-019051-gtruu1op 245 39 cytotoxic cytotoxic JJ cord-019051-gtruu1op 245 40 T t NN cord-019051-gtruu1op 245 41 cell cell NN cord-019051-gtruu1op 245 42 ( ( -LRB- cord-019051-gtruu1op 245 43 CTL CTL NNP cord-019051-gtruu1op 245 44 ) ) -RRB- cord-019051-gtruu1op 245 45 response response NN cord-019051-gtruu1op 245 46 [ [ -LRB- cord-019051-gtruu1op 245 47 87 87 CD cord-019051-gtruu1op 245 48 , , , cord-019051-gtruu1op 245 49 88 88 CD cord-019051-gtruu1op 245 50 ] ] -RRB- cord-019051-gtruu1op 245 51 . . . cord-019051-gtruu1op 246 1 STAT1 stat1 XX cord-019051-gtruu1op 247 1 ( ( -LRB- cord-019051-gtruu1op 247 2 -/- -/- NNP cord-019051-gtruu1op 247 3 ) ) -RRB- cord-019051-gtruu1op 247 4 mice mouse NNS cord-019051-gtruu1op 247 5 with with IN cord-019051-gtruu1op 247 6 a a DT cord-019051-gtruu1op 247 7 BALB BALB NNP cord-019051-gtruu1op 247 8 / / SYM cord-019051-gtruu1op 247 9 c c NN cord-019051-gtruu1op 247 10 background background NN cord-019051-gtruu1op 247 11 have have VBP cord-019051-gtruu1op 247 12 been be VBN cord-019051-gtruu1op 247 13 described describe VBN cord-019051-gtruu1op 247 14 as as IN cord-019051-gtruu1op 247 15 having have VBG cord-019051-gtruu1op 247 16 an an DT cord-019051-gtruu1op 247 17 excellent excellent JJ cord-019051-gtruu1op 247 18 RSV rsv NN cord-019051-gtruu1op 247 19 disease disease NN cord-019051-gtruu1op 247 20 phenotype phenotype NN cord-019051-gtruu1op 247 21 ( ( -LRB- cord-019051-gtruu1op 247 22 reviewed review VBN cord-019051-gtruu1op 247 23 in in IN cord-019051-gtruu1op 247 24 [ [ -LRB- cord-019051-gtruu1op 247 25 79 79 CD cord-019051-gtruu1op 247 26 ] ] -RRB- cord-019051-gtruu1op 247 27 ) ) -RRB- cord-019051-gtruu1op 247 28 . . . cord-019051-gtruu1op 248 1 Although although IN cord-019051-gtruu1op 248 2 this this DT cord-019051-gtruu1op 248 3 model model NN cord-019051-gtruu1op 248 4 has have VBZ cord-019051-gtruu1op 248 5 the the DT cord-019051-gtruu1op 248 6 limitation limitation NN cord-019051-gtruu1op 248 7 that that IN cord-019051-gtruu1op 248 8 it -PRON- PRP cord-019051-gtruu1op 248 9 probably probably RB cord-019051-gtruu1op 248 10 does do VBZ cord-019051-gtruu1op 248 11 not not RB cord-019051-gtruu1op 248 12 exactly exactly RB cord-019051-gtruu1op 248 13 mirror mirror VB cord-019051-gtruu1op 248 14 the the DT cord-019051-gtruu1op 248 15 complexity complexity NN cord-019051-gtruu1op 248 16 of of IN cord-019051-gtruu1op 248 17 a a DT cord-019051-gtruu1op 248 18 natural natural JJ cord-019051-gtruu1op 248 19 infection infection NN cord-019051-gtruu1op 248 20 in in IN cord-019051-gtruu1op 248 21 humans human NNS cord-019051-gtruu1op 248 22 , , , cord-019051-gtruu1op 248 23 it -PRON- PRP cord-019051-gtruu1op 248 24 is be VBZ cord-019051-gtruu1op 248 25 regarded regard VBN cord-019051-gtruu1op 248 26 as as IN cord-019051-gtruu1op 248 27 an an DT cord-019051-gtruu1op 248 28 attractive attractive JJ cord-019051-gtruu1op 248 29 tool tool NN cord-019051-gtruu1op 248 30 to to TO cord-019051-gtruu1op 248 31 study study VB cord-019051-gtruu1op 248 32 RSV RSV NNP cord-019051-gtruu1op 248 33 pathogenesis pathogenesis NN cord-019051-gtruu1op 248 34 and and CC cord-019051-gtruu1op 248 35 evaluating evaluate VBG cord-019051-gtruu1op 248 36 novel novel JJ cord-019051-gtruu1op 248 37 therapies therapy NNS cord-019051-gtruu1op 248 38 . . . cord-019051-gtruu1op 249 1 In in IN cord-019051-gtruu1op 249 2 addition addition NN cord-019051-gtruu1op 249 3 to to IN cord-019051-gtruu1op 249 4 other other JJ cord-019051-gtruu1op 249 5 mouse mouse NN cord-019051-gtruu1op 249 6 models model NNS cord-019051-gtruu1op 249 7 and and CC cord-019051-gtruu1op 249 8 the the DT cord-019051-gtruu1op 249 9 infection infection NN cord-019051-gtruu1op 249 10 in in IN cord-019051-gtruu1op 249 11 chinchillas chinchilla NNS cord-019051-gtruu1op 249 12 [ [ -LRB- cord-019051-gtruu1op 249 13 89 89 CD cord-019051-gtruu1op 249 14 ] ] -RRB- cord-019051-gtruu1op 249 15 , , , cord-019051-gtruu1op 249 16 infection infection NN cord-019051-gtruu1op 249 17 of of IN cord-019051-gtruu1op 249 18 natural natural JJ cord-019051-gtruu1op 249 19 hosts host NNS cord-019051-gtruu1op 249 20 has have VBZ cord-019051-gtruu1op 249 21 been be VBN cord-019051-gtruu1op 249 22 studied study VBN cord-019051-gtruu1op 249 23 in in IN cord-019051-gtruu1op 249 24 detail detail NN cord-019051-gtruu1op 249 25 . . . cord-019051-gtruu1op 250 1 Bovine bovine JJ cord-019051-gtruu1op 250 2 respiratory respiratory JJ cord-019051-gtruu1op 250 3 syncytial syncytial JJ cord-019051-gtruu1op 250 4 virus virus NN cord-019051-gtruu1op 250 5 is be VBZ cord-019051-gtruu1op 250 6 a a DT cord-019051-gtruu1op 250 7 major major JJ cord-019051-gtruu1op 250 8 cause cause NN cord-019051-gtruu1op 250 9 of of IN cord-019051-gtruu1op 250 10 respiratory respiratory JJ cord-019051-gtruu1op 250 11 illness illness NN cord-019051-gtruu1op 250 12 in in IN cord-019051-gtruu1op 250 13 calves calf NNS cord-019051-gtruu1op 250 14 and and CC cord-019051-gtruu1op 250 15 has have VBZ cord-019051-gtruu1op 250 16 been be VBN cord-019051-gtruu1op 250 17 studied study VBN cord-019051-gtruu1op 250 18 in in IN cord-019051-gtruu1op 250 19 this this DT cord-019051-gtruu1op 250 20 context context NN cord-019051-gtruu1op 250 21 . . . cord-019051-gtruu1op 251 1 The the DT cord-019051-gtruu1op 251 2 clinical clinical JJ cord-019051-gtruu1op 251 3 signs sign NNS cord-019051-gtruu1op 251 4 after after IN cord-019051-gtruu1op 251 5 experimental experimental JJ cord-019051-gtruu1op 251 6 infection infection NN cord-019051-gtruu1op 251 7 include include VBP cord-019051-gtruu1op 251 8 cough cough NN cord-019051-gtruu1op 251 9 , , , cord-019051-gtruu1op 251 10 lung lung NN cord-019051-gtruu1op 251 11 sound sound NN cord-019051-gtruu1op 251 12 , , , cord-019051-gtruu1op 251 13 dyspnea dyspnea NN cord-019051-gtruu1op 251 14 , , , cord-019051-gtruu1op 251 15 fever fever NN cord-019051-gtruu1op 251 16 , , , cord-019051-gtruu1op 251 17 increased increase VBN cord-019051-gtruu1op 251 18 respiratory respiratory JJ cord-019051-gtruu1op 251 19 rate rate NN cord-019051-gtruu1op 251 20 and and CC cord-019051-gtruu1op 251 21 pulmonary pulmonary JJ cord-019051-gtruu1op 251 22 resistance resistance NN cord-019051-gtruu1op 251 23 . . . cord-019051-gtruu1op 252 1 Prominent prominent JJ cord-019051-gtruu1op 252 2 histological histological JJ cord-019051-gtruu1op 252 3 findings finding NNS cord-019051-gtruu1op 252 4 include include VBP cord-019051-gtruu1op 252 5 proliferative proliferative JJ cord-019051-gtruu1op 252 6 bronchiolitis bronchiolitis NN cord-019051-gtruu1op 252 7 , , , cord-019051-gtruu1op 252 8 alveolitis alveolitis NNP cord-019051-gtruu1op 252 9 , , , cord-019051-gtruu1op 252 10 syncytia syncytia NN cord-019051-gtruu1op 252 11 , , , cord-019051-gtruu1op 252 12 and and CC cord-019051-gtruu1op 252 13 , , , cord-019051-gtruu1op 252 14 to to IN cord-019051-gtruu1op 252 15 some some DT cord-019051-gtruu1op 252 16 extent extent NN cord-019051-gtruu1op 252 17 , , , cord-019051-gtruu1op 252 18 emphysema emphysema NN cord-019051-gtruu1op 252 19 [ [ -LRB- cord-019051-gtruu1op 252 20 90 90 CD cord-019051-gtruu1op 252 21 ] ] -RRB- cord-019051-gtruu1op 252 22 . . . cord-019051-gtruu1op 253 1 RSV RSV NNP cord-019051-gtruu1op 253 2 infection infection NN cord-019051-gtruu1op 253 3 of of IN cord-019051-gtruu1op 253 4 calves calf NNS cord-019051-gtruu1op 253 5 might may MD cord-019051-gtruu1op 253 6 be be VB cord-019051-gtruu1op 253 7 useful useful JJ cord-019051-gtruu1op 253 8 for for IN cord-019051-gtruu1op 253 9 evaluating evaluate VBG cord-019051-gtruu1op 253 10 vaccination vaccination NN cord-019051-gtruu1op 253 11 strategies strategy NNS cord-019051-gtruu1op 253 12 ; ; : cord-019051-gtruu1op 253 13 however however RB cord-019051-gtruu1op 253 14 , , , cord-019051-gtruu1op 253 15 it -PRON- PRP cord-019051-gtruu1op 253 16 is be VBZ cord-019051-gtruu1op 253 17 not not RB cord-019051-gtruu1op 253 18 an an DT cord-019051-gtruu1op 253 19 animal animal NN cord-019051-gtruu1op 253 20 model model NN cord-019051-gtruu1op 253 21 for for IN cord-019051-gtruu1op 253 22 the the DT cord-019051-gtruu1op 253 23 evaluation evaluation NN cord-019051-gtruu1op 253 24 of of IN cord-019051-gtruu1op 253 25 novel novel JJ cord-019051-gtruu1op 253 26 therapies therapy NNS cord-019051-gtruu1op 253 27 . . . cord-019051-gtruu1op 254 1 The the DT cord-019051-gtruu1op 254 2 list list NN cord-019051-gtruu1op 254 3 of of IN cord-019051-gtruu1op 254 4 experimental experimental JJ cord-019051-gtruu1op 254 5 models model NNS cord-019051-gtruu1op 254 6 also also RB cord-019051-gtruu1op 254 7 includes include VBZ cord-019051-gtruu1op 254 8 pneumonia pneumonia NN cord-019051-gtruu1op 254 9 virus virus NN cord-019051-gtruu1op 254 10 infection infection NN cord-019051-gtruu1op 254 11 of of IN cord-019051-gtruu1op 254 12 mice mouse NNS cord-019051-gtruu1op 254 13 ( ( -LRB- cord-019051-gtruu1op 254 14 PVM PVM NNP cord-019051-gtruu1op 254 15 ) ) -RRB- cord-019051-gtruu1op 254 16 [ [ -LRB- cord-019051-gtruu1op 254 17 91 91 CD cord-019051-gtruu1op 254 18 ] ] -RRB- cord-019051-gtruu1op 254 19 . . . cord-019051-gtruu1op 255 1 Although although IN cord-019051-gtruu1op 255 2 the the DT cord-019051-gtruu1op 255 3 PVM PVM NNP cord-019051-gtruu1op 255 4 model model NN cord-019051-gtruu1op 255 5 of of IN cord-019051-gtruu1op 255 6 respiratory respiratory JJ cord-019051-gtruu1op 255 7 disease disease NN cord-019051-gtruu1op 255 8 is be VBZ cord-019051-gtruu1op 255 9 interesting interesting JJ cord-019051-gtruu1op 255 10 because because IN cord-019051-gtruu1op 255 11 it -PRON- PRP cord-019051-gtruu1op 255 12 shows show VBZ cord-019051-gtruu1op 255 13 the the DT cord-019051-gtruu1op 255 14 phenotype phenotype NN cord-019051-gtruu1op 255 15 of of IN cord-019051-gtruu1op 255 16 a a DT cord-019051-gtruu1op 255 17 natural natural JJ cord-019051-gtruu1op 255 18 infection infection NN cord-019051-gtruu1op 255 19 , , , cord-019051-gtruu1op 255 20 PVM PVM NNP cord-019051-gtruu1op 255 21 differs differ VBZ cord-019051-gtruu1op 255 22 from from IN cord-019051-gtruu1op 255 23 RSV RSV NNP cord-019051-gtruu1op 255 24 including include VBG cord-019051-gtruu1op 255 25 the the DT cord-019051-gtruu1op 255 26 G g NN cord-019051-gtruu1op 255 27 and and CC cord-019051-gtruu1op 255 28 the the DT cord-019051-gtruu1op 255 29 NS1 ns1 NN cord-019051-gtruu1op 255 30 proteins protein NNS cord-019051-gtruu1op 255 31 that that WDT cord-019051-gtruu1op 255 32 fulfill fulfill VBP cord-019051-gtruu1op 255 33 important important JJ cord-019051-gtruu1op 255 34 functions function NNS cord-019051-gtruu1op 255 35 during during IN cord-019051-gtruu1op 255 36 RSV RSV NNP cord-019051-gtruu1op 255 37 infection infection NN cord-019051-gtruu1op 255 38 . . . cord-019051-gtruu1op 256 1 Human human JJ cord-019051-gtruu1op 256 2 parainfluenza parainfluenza NN cord-019051-gtruu1op 256 3 viruses virus NNS cord-019051-gtruu1op 256 4 ( ( -LRB- cord-019051-gtruu1op 256 5 HPIV HPIV NNP cord-019051-gtruu1op 256 6 ) ) -RRB- cord-019051-gtruu1op 256 7 are be VBP cord-019051-gtruu1op 256 8 important important JJ cord-019051-gtruu1op 256 9 causes cause NNS cord-019051-gtruu1op 256 10 of of IN cord-019051-gtruu1op 256 11 respiratory respiratory JJ cord-019051-gtruu1op 256 12 diseases disease NNS cord-019051-gtruu1op 256 13 in in IN cord-019051-gtruu1op 256 14 infants infant NNS cord-019051-gtruu1op 256 15 and and CC cord-019051-gtruu1op 256 16 children child NNS cord-019051-gtruu1op 256 17 . . . cord-019051-gtruu1op 257 1 They -PRON- PRP cord-019051-gtruu1op 257 2 usually usually RB cord-019051-gtruu1op 257 3 cause cause VBP cord-019051-gtruu1op 257 4 URTI URTI NNP cord-019051-gtruu1op 257 5 of of IN cord-019051-gtruu1op 257 6 which which WDT cord-019051-gtruu1op 257 7 30 30 CD cord-019051-gtruu1op 257 8 - - SYM cord-019051-gtruu1op 257 9 50 50 CD cord-019051-gtruu1op 257 10 % % NN cord-019051-gtruu1op 257 11 may may MD cord-019051-gtruu1op 257 12 be be VB cord-019051-gtruu1op 257 13 accompanied accompany VBN cord-019051-gtruu1op 257 14 by by IN cord-019051-gtruu1op 257 15 otitis otitis NN cord-019051-gtruu1op 257 16 media medium NNS cord-019051-gtruu1op 257 17 . . . cord-019051-gtruu1op 258 1 HPIV HPIV NNP cord-019051-gtruu1op 258 2 may may MD cord-019051-gtruu1op 258 3 also also RB cord-019051-gtruu1op 258 4 cause cause VB cord-019051-gtruu1op 258 5 LRTI LRTI NNP cord-019051-gtruu1op 258 6 , , , cord-019051-gtruu1op 258 7 about about RB cord-019051-gtruu1op 258 8 0.3 0.3 CD cord-019051-gtruu1op 258 9 % % NN cord-019051-gtruu1op 258 10 of of IN cord-019051-gtruu1op 258 11 which which WDT cord-019051-gtruu1op 258 12 require require VBP cord-019051-gtruu1op 258 13 hospitalization hospitalization NN cord-019051-gtruu1op 258 14 . . . cord-019051-gtruu1op 259 1 HPIV1 HPIV1 NNP cord-019051-gtruu1op 259 2 - - HYPH cord-019051-gtruu1op 259 3 3 3 CD cord-019051-gtruu1op 259 4 infections infection NNS cord-019051-gtruu1op 259 5 are be VBP cord-019051-gtruu1op 259 6 second second JJ cord-019051-gtruu1op 259 7 to to IN cord-019051-gtruu1op 259 8 RSV RSV NNP cord-019051-gtruu1op 259 9 infections infection NNS cord-019051-gtruu1op 259 10 as as IN cord-019051-gtruu1op 259 11 the the DT cord-019051-gtruu1op 259 12 viral viral JJ cord-019051-gtruu1op 259 13 cause cause NN cord-019051-gtruu1op 259 14 of of IN cord-019051-gtruu1op 259 15 serious serious JJ cord-019051-gtruu1op 259 16 acute acute JJ cord-019051-gtruu1op 259 17 respiratory respiratory JJ cord-019051-gtruu1op 259 18 infections infection NNS cord-019051-gtruu1op 259 19 in in IN cord-019051-gtruu1op 259 20 young young JJ cord-019051-gtruu1op 259 21 children child NNS cord-019051-gtruu1op 259 22 that that WDT cord-019051-gtruu1op 259 23 occur occur VBP cord-019051-gtruu1op 259 24 primarily primarily RB cord-019051-gtruu1op 259 25 in in IN cord-019051-gtruu1op 259 26 the the DT cord-019051-gtruu1op 259 27 first first JJ cord-019051-gtruu1op 259 28 6 6 CD cord-019051-gtruu1op 259 29 months month NNS cord-019051-gtruu1op 259 30 of of IN cord-019051-gtruu1op 259 31 life life NN cord-019051-gtruu1op 259 32 [ [ -LRB- cord-019051-gtruu1op 259 33 92 92 CD cord-019051-gtruu1op 259 34 , , , cord-019051-gtruu1op 259 35 93 93 CD cord-019051-gtruu1op 259 36 ] ] -RRB- cord-019051-gtruu1op 259 37 . . . cord-019051-gtruu1op 260 1 HPIV3 HPIV3 NNP cord-019051-gtruu1op 260 2 may may MD cord-019051-gtruu1op 260 3 cause cause VB cord-019051-gtruu1op 260 4 severe severe JJ cord-019051-gtruu1op 260 5 diseases disease NNS cord-019051-gtruu1op 260 6 . . . cord-019051-gtruu1op 261 1 Approximately approximately RB cord-019051-gtruu1op 261 2 80 80 CD cord-019051-gtruu1op 261 3 % % NN cord-019051-gtruu1op 261 4 of of IN cord-019051-gtruu1op 261 5 infants infant NNS cord-019051-gtruu1op 261 6 and and CC cord-019051-gtruu1op 261 7 children child NNS cord-019051-gtruu1op 261 8 infected infect VBN cord-019051-gtruu1op 261 9 with with IN cord-019051-gtruu1op 261 10 HPIV3 hpiv3 NN cord-019051-gtruu1op 261 11 developed develop VBN cord-019051-gtruu1op 261 12 febrile febrile JJ cord-019051-gtruu1op 261 13 illness illness NN cord-019051-gtruu1op 261 14 and and CC cord-019051-gtruu1op 261 15 one one CD cord-019051-gtruu1op 261 16 third third NN cord-019051-gtruu1op 261 17 of of IN cord-019051-gtruu1op 261 18 these these DT cord-019051-gtruu1op 261 19 infected infect VBN cord-019051-gtruu1op 261 20 individuals individual NNS cord-019051-gtruu1op 261 21 developed develop VBD cord-019051-gtruu1op 261 22 LRTI LRTI NNP cord-019051-gtruu1op 261 23 , , , cord-019051-gtruu1op 261 24 resulting result VBG cord-019051-gtruu1op 261 25 in in IN cord-019051-gtruu1op 261 26 bronchitis bronchitis NN cord-019051-gtruu1op 261 27 or or CC cord-019051-gtruu1op 261 28 pneumonia pneumonia NN cord-019051-gtruu1op 261 29 [ [ -LRB- cord-019051-gtruu1op 261 30 93 93 CD cord-019051-gtruu1op 261 31 ] ] -RRB- cord-019051-gtruu1op 261 32 [ [ -LRB- cord-019051-gtruu1op 261 33 94 94 CD cord-019051-gtruu1op 261 34 ] ] -RRB- cord-019051-gtruu1op 261 35 [ [ -LRB- cord-019051-gtruu1op 261 36 95 95 CD cord-019051-gtruu1op 261 37 ] ] -RRB- cord-019051-gtruu1op 261 38 . . . cord-019051-gtruu1op 262 1 Most Most JJS cord-019051-gtruu1op 262 2 children child NNS cord-019051-gtruu1op 262 3 have have VBP cord-019051-gtruu1op 262 4 been be VBN cord-019051-gtruu1op 262 5 infected infect VBN cord-019051-gtruu1op 262 6 with with IN cord-019051-gtruu1op 262 7 HPIV3 hpiv3 NN cord-019051-gtruu1op 262 8 by by IN cord-019051-gtruu1op 262 9 the the DT cord-019051-gtruu1op 262 10 age age NN cord-019051-gtruu1op 262 11 of of IN cord-019051-gtruu1op 262 12 2 2 CD cord-019051-gtruu1op 262 13 years year NNS cord-019051-gtruu1op 262 14 . . . cord-019051-gtruu1op 263 1 Croup croup NN cord-019051-gtruu1op 263 2 is be VBZ cord-019051-gtruu1op 263 3 the the DT cord-019051-gtruu1op 263 4 main main JJ cord-019051-gtruu1op 263 5 clinical clinical JJ cord-019051-gtruu1op 263 6 manifestation manifestation NN cord-019051-gtruu1op 263 7 of of IN cord-019051-gtruu1op 263 8 infection infection NN cord-019051-gtruu1op 263 9 with with IN cord-019051-gtruu1op 263 10 parainfluenza parainfluenza NNP cord-019051-gtruu1op 263 11 viruses virus NNS cord-019051-gtruu1op 263 12 , , , cord-019051-gtruu1op 263 13 especially especially RB cord-019051-gtruu1op 263 14 HPIV1 HPIV1 NNP cord-019051-gtruu1op 263 15 and and CC cord-019051-gtruu1op 263 16 2 2 CD cord-019051-gtruu1op 263 17 , , , cord-019051-gtruu1op 263 18 and and CC cord-019051-gtruu1op 263 19 these these DT cord-019051-gtruu1op 263 20 infections infection NNS cord-019051-gtruu1op 263 21 may may MD cord-019051-gtruu1op 263 22 extend extend VB cord-019051-gtruu1op 263 23 to to IN cord-019051-gtruu1op 263 24 the the DT cord-019051-gtruu1op 263 25 lower low JJR cord-019051-gtruu1op 263 26 respiratory respiratory JJ cord-019051-gtruu1op 263 27 tract tract NN cord-019051-gtruu1op 263 28 and and CC cord-019051-gtruu1op 263 29 result result NN cord-019051-gtruu1op 263 30 in in IN cord-019051-gtruu1op 263 31 pneumonia pneumonia NN cord-019051-gtruu1op 263 32 [ [ -LRB- cord-019051-gtruu1op 263 33 94 94 CD cord-019051-gtruu1op 263 34 ] ] -RRB- cord-019051-gtruu1op 263 35 . . . cord-019051-gtruu1op 264 1 HPIV4 hpiv4 RB cord-019051-gtruu1op 264 2 mainly mainly RB cord-019051-gtruu1op 264 3 causes cause VBZ cord-019051-gtruu1op 264 4 mild mild JJ cord-019051-gtruu1op 264 5 URTI URTI NNP cord-019051-gtruu1op 264 6 in in IN cord-019051-gtruu1op 264 7 children child NNS cord-019051-gtruu1op 264 8 and and CC cord-019051-gtruu1op 264 9 adults adult NNS cord-019051-gtruu1op 264 10 [ [ -LRB- cord-019051-gtruu1op 264 11 93 93 CD cord-019051-gtruu1op 264 12 ] ] -RRB- cord-019051-gtruu1op 264 13 . . . cord-019051-gtruu1op 265 1 Along along IN cord-019051-gtruu1op 265 2 with with IN cord-019051-gtruu1op 265 3 RSV RSV NNP cord-019051-gtruu1op 265 4 , , , cord-019051-gtruu1op 265 5 HPIV HPIV NNP cord-019051-gtruu1op 265 6 are be VBP cord-019051-gtruu1op 265 7 also also RB cord-019051-gtruu1op 265 8 a a DT cord-019051-gtruu1op 265 9 leading lead VBG cord-019051-gtruu1op 265 10 causative causative JJ cord-019051-gtruu1op 265 11 agent agent NN cord-019051-gtruu1op 265 12 of of IN cord-019051-gtruu1op 265 13 serious serious JJ cord-019051-gtruu1op 265 14 acute acute JJ cord-019051-gtruu1op 265 15 respiratory respiratory JJ cord-019051-gtruu1op 265 16 infections infection NNS cord-019051-gtruu1op 265 17 and and CC cord-019051-gtruu1op 265 18 community community NN cord-019051-gtruu1op 265 19 - - HYPH cord-019051-gtruu1op 265 20 acquired acquire VBN cord-019051-gtruu1op 265 21 respiratory respiratory JJ cord-019051-gtruu1op 265 22 disease disease NN cord-019051-gtruu1op 265 23 requiring require VBG cord-019051-gtruu1op 265 24 hospitalization hospitalization NN cord-019051-gtruu1op 265 25 in in IN cord-019051-gtruu1op 265 26 adults adult NNS cord-019051-gtruu1op 265 27 . . . cord-019051-gtruu1op 266 1 The the DT cord-019051-gtruu1op 266 2 proportions proportion NNS cord-019051-gtruu1op 266 3 of of IN cord-019051-gtruu1op 266 4 hospitalizations hospitalization NNS cord-019051-gtruu1op 266 5 associated associate VBN cord-019051-gtruu1op 266 6 with with IN cord-019051-gtruu1op 266 7 HPIV HPIV NNP cord-019051-gtruu1op 266 8 infection infection NN cord-019051-gtruu1op 266 9 vary vary VBP cord-019051-gtruu1op 266 10 widely widely RB cord-019051-gtruu1op 266 11 in in IN cord-019051-gtruu1op 266 12 hospital hospital NN cord-019051-gtruu1op 266 13 - - HYPH cord-019051-gtruu1op 266 14 based base VBN cord-019051-gtruu1op 266 15 studies study NNS cord-019051-gtruu1op 266 16 . . . cord-019051-gtruu1op 267 1 According accord VBG cord-019051-gtruu1op 267 2 to to IN cord-019051-gtruu1op 267 3 the the DT cord-019051-gtruu1op 267 4 WHO WHO NNP cord-019051-gtruu1op 267 5 , , , cord-019051-gtruu1op 267 6 HPIV1 HPIV1 NNP cord-019051-gtruu1op 267 7 is be VBZ cord-019051-gtruu1op 267 8 estimated estimate VBN cord-019051-gtruu1op 267 9 to to TO cord-019051-gtruu1op 267 10 account account VB cord-019051-gtruu1op 267 11 for for IN cord-019051-gtruu1op 267 12 5800 5800 CD cord-019051-gtruu1op 267 13 - - SYM cord-019051-gtruu1op 267 14 28 28 CD cord-019051-gtruu1op 267 15 900 900 CD cord-019051-gtruu1op 267 16 annual annual JJ cord-019051-gtruu1op 267 17 hospitalizations hospitalization NNS cord-019051-gtruu1op 267 18 in in IN cord-019051-gtruu1op 267 19 the the DT cord-019051-gtruu1op 267 20 USA USA NNP cord-019051-gtruu1op 267 21 , , , cord-019051-gtruu1op 268 1 HPIV2 HPIV2 NNP cord-019051-gtruu1op 268 2 for for IN cord-019051-gtruu1op 268 3 1800 1800 CD cord-019051-gtruu1op 268 4 - - SYM cord-019051-gtruu1op 268 5 15 15 CD cord-019051-gtruu1op 268 6 600 600 CD cord-019051-gtruu1op 268 7 hospitalizations hospitalization NNS cord-019051-gtruu1op 268 8 , , , cord-019051-gtruu1op 268 9 and and CC cord-019051-gtruu1op 268 10 HPIV3 hpiv3 NN cord-019051-gtruu1op 268 11 for for IN cord-019051-gtruu1op 268 12 8700 8700 CD cord-019051-gtruu1op 268 13 - - HYPH cord-019051-gtruu1op 268 14 52 52 CD cord-019051-gtruu1op 268 15 000 000 CD cord-019051-gtruu1op 268 16 hospitalizations hospitalization NNS cord-019051-gtruu1op 268 17 [ [ -LRB- cord-019051-gtruu1op 268 18 92 92 CD cord-019051-gtruu1op 268 19 ] ] -RRB- cord-019051-gtruu1op 268 20 . . . cord-019051-gtruu1op 269 1 Parainfluenza Parainfluenza NNP cord-019051-gtruu1op 269 2 viruses virus NNS cord-019051-gtruu1op 269 3 belong belong VBP cord-019051-gtruu1op 269 4 to to IN cord-019051-gtruu1op 269 5 the the DT cord-019051-gtruu1op 269 6 order order NN cord-019051-gtruu1op 269 7 of of IN cord-019051-gtruu1op 269 8 Mononegavirales Mononegavirales NNP cord-019051-gtruu1op 269 9 , , , cord-019051-gtruu1op 269 10 family family NN cord-019051-gtruu1op 269 11 Paramyxoviridae Paramyxoviridae NNP cord-019051-gtruu1op 269 12 , , , cord-019051-gtruu1op 269 13 subfamily subfamily NN cord-019051-gtruu1op 269 14 Paramyxovirinae Paramyxovirinae NNP cord-019051-gtruu1op 269 15 . . . cord-019051-gtruu1op 270 1 HPIV1 HPIV1 NNP cord-019051-gtruu1op 271 1 and and CC cord-019051-gtruu1op 271 2 3 3 CD cord-019051-gtruu1op 271 3 belong belong VBP cord-019051-gtruu1op 271 4 to to IN cord-019051-gtruu1op 271 5 the the DT cord-019051-gtruu1op 271 6 genus genus NN cord-019051-gtruu1op 271 7 Respirovirus Respirovirus NNP cord-019051-gtruu1op 271 8 , , , cord-019051-gtruu1op 271 9 and and CC cord-019051-gtruu1op 271 10 HPIV2 hpiv2 NN cord-019051-gtruu1op 271 11 and and CC cord-019051-gtruu1op 271 12 4 4 CD cord-019051-gtruu1op 271 13 to to IN cord-019051-gtruu1op 271 14 the the DT cord-019051-gtruu1op 271 15 genus genus NN cord-019051-gtruu1op 271 16 Rubulavirus Rubulavirus NNP cord-019051-gtruu1op 271 17 [ [ -LRB- cord-019051-gtruu1op 271 18 96 96 CD cord-019051-gtruu1op 271 19 ] ] -RRB- cord-019051-gtruu1op 271 20 . . . cord-019051-gtruu1op 272 1 The the DT cord-019051-gtruu1op 272 2 virions virion NNS cord-019051-gtruu1op 272 3 are be VBP cord-019051-gtruu1op 272 4 spherical spherical JJ cord-019051-gtruu1op 272 5 enveloped envelop VBN cord-019051-gtruu1op 272 6 particles particle NNS cord-019051-gtruu1op 272 7 of of IN cord-019051-gtruu1op 272 8 approximately approximately RB cord-019051-gtruu1op 272 9 150 150 CD cord-019051-gtruu1op 272 10 - - SYM cord-019051-gtruu1op 272 11 250 250 CD cord-019051-gtruu1op 272 12 nm nm NN cord-019051-gtruu1op 272 13 in in IN cord-019051-gtruu1op 272 14 diameter diameter NN cord-019051-gtruu1op 272 15 with with IN cord-019051-gtruu1op 272 16 an an DT cord-019051-gtruu1op 272 17 internal internal JJ cord-019051-gtruu1op 272 18 helical helical JJ cord-019051-gtruu1op 272 19 nucleocapsid nucleocapsid NN cord-019051-gtruu1op 272 20 . . . cord-019051-gtruu1op 273 1 Virions virion NNS cord-019051-gtruu1op 273 2 are be VBP cord-019051-gtruu1op 273 3 enveloped envelop VBN cord-019051-gtruu1op 273 4 by by IN cord-019051-gtruu1op 273 5 a a DT cord-019051-gtruu1op 273 6 lipid lipid NN cord-019051-gtruu1op 273 7 bilayer bilayer NN cord-019051-gtruu1op 273 8 membrane membrane NN cord-019051-gtruu1op 273 9 that that WDT cord-019051-gtruu1op 273 10 bears bear VBZ cord-019051-gtruu1op 273 11 spike spike NN cord-019051-gtruu1op 273 12 - - HYPH cord-019051-gtruu1op 273 13 like like JJ cord-019051-gtruu1op 273 14 projections projection NNS cord-019051-gtruu1op 273 15 composed compose VBN cord-019051-gtruu1op 273 16 of of IN cord-019051-gtruu1op 273 17 hemagglutinin hemagglutinin NN cord-019051-gtruu1op 273 18 - - , cord-019051-gtruu1op 273 19 neuraminidase neuraminidase FW cord-019051-gtruu1op 273 20 ( ( -LRB- cord-019051-gtruu1op 273 21 HN HN NNP cord-019051-gtruu1op 273 22 ) ) -RRB- cord-019051-gtruu1op 273 23 and and CC cord-019051-gtruu1op 273 24 fusion fusion NN cord-019051-gtruu1op 273 25 ( ( -LRB- cord-019051-gtruu1op 273 26 F F NNP cord-019051-gtruu1op 273 27 ) ) -RRB- cord-019051-gtruu1op 273 28 protein protein NN cord-019051-gtruu1op 273 29 [ [ -LRB- cord-019051-gtruu1op 273 30 97 97 CD cord-019051-gtruu1op 273 31 ] ] -RRB- cord-019051-gtruu1op 273 32 . . . cord-019051-gtruu1op 274 1 As as IN cord-019051-gtruu1op 274 2 for for IN cord-019051-gtruu1op 274 3 other other JJ cord-019051-gtruu1op 274 4 paramyxoviruses paramyxovirus NNS cord-019051-gtruu1op 274 5 , , , cord-019051-gtruu1op 274 6 all all DT cord-019051-gtruu1op 274 7 HPIVs hpiv NNS cord-019051-gtruu1op 274 8 contain contain VBP cord-019051-gtruu1op 274 9 a a DT cord-019051-gtruu1op 274 10 negative negative JJ cord-019051-gtruu1op 274 11 strand strand NN cord-019051-gtruu1op 274 12 , , , cord-019051-gtruu1op 274 13 ~15 ~15 NFP cord-019051-gtruu1op 274 14 500-nucleotide 500-nucleotide CD cord-019051-gtruu1op 274 15 - - HYPH cord-019051-gtruu1op 274 16 long long JJ cord-019051-gtruu1op 274 17 non non JJ cord-019051-gtruu1op 274 18 - - JJ cord-019051-gtruu1op 274 19 segmented segmented JJ cord-019051-gtruu1op 274 20 RNA RNA NNP cord-019051-gtruu1op 274 21 genome genome NN cord-019051-gtruu1op 274 22 [ [ -LRB- cord-019051-gtruu1op 274 23 93 93 CD cord-019051-gtruu1op 274 24 ] ] -RRB- cord-019051-gtruu1op 274 25 encoding encode VBG cord-019051-gtruu1op 274 26 two two CD cord-019051-gtruu1op 274 27 envelope envelope NN cord-019051-gtruu1op 274 28 glycoproteins glycoprotein NNS cord-019051-gtruu1op 274 29 , , , cord-019051-gtruu1op 274 30 the the DT cord-019051-gtruu1op 274 31 HN HN NNP cord-019051-gtruu1op 274 32 , , , cord-019051-gtruu1op 274 33 and and CC cord-019051-gtruu1op 274 34 the the DT cord-019051-gtruu1op 274 35 F F NNP cord-019051-gtruu1op 274 36 protein protein NN cord-019051-gtruu1op 274 37 , , , cord-019051-gtruu1op 274 38 a a DT cord-019051-gtruu1op 274 39 matrix matrix NN cord-019051-gtruu1op 274 40 protein protein NN cord-019051-gtruu1op 274 41 ( ( -LRB- cord-019051-gtruu1op 274 42 M M NNP cord-019051-gtruu1op 274 43 ) ) -RRB- cord-019051-gtruu1op 274 44 , , , cord-019051-gtruu1op 274 45 a a DT cord-019051-gtruu1op 274 46 nucleocapsid nucleocapsid NN cord-019051-gtruu1op 274 47 protein protein NN cord-019051-gtruu1op 274 48 ( ( -LRB- cord-019051-gtruu1op 274 49 NP NP NNP cord-019051-gtruu1op 274 50 ) ) -RRB- cord-019051-gtruu1op 274 51 and and CC cord-019051-gtruu1op 274 52 several several JJ cord-019051-gtruu1op 274 53 nonstructural nonstructural JJ cord-019051-gtruu1op 274 54 proteins protein NNS cord-019051-gtruu1op 274 55 including include VBG cord-019051-gtruu1op 274 56 a a DT cord-019051-gtruu1op 274 57 polymerase polymerase NN cord-019051-gtruu1op 274 58 - - HYPH cord-019051-gtruu1op 274 59 associated associate VBN cord-019051-gtruu1op 274 60 protein protein NN cord-019051-gtruu1op 274 61 ( ( -LRB- cord-019051-gtruu1op 274 62 P p NN cord-019051-gtruu1op 274 63 / / SYM cord-019051-gtruu1op 274 64 V v NN cord-019051-gtruu1op 274 65 ) ) -RRB- cord-019051-gtruu1op 274 66 and and CC cord-019051-gtruu1op 274 67 the the DT cord-019051-gtruu1op 274 68 viral viral JJ cord-019051-gtruu1op 274 69 replicase replicase NN cord-019051-gtruu1op 274 70 ( ( -LRB- cord-019051-gtruu1op 274 71 L L NNP cord-019051-gtruu1op 274 72 ) ) -RRB- cord-019051-gtruu1op 274 73 ( ( -LRB- cord-019051-gtruu1op 274 74 reviewed review VBN cord-019051-gtruu1op 274 75 in in IN cord-019051-gtruu1op 274 76 [ [ -LRB- cord-019051-gtruu1op 274 77 93 93 CD cord-019051-gtruu1op 274 78 ] ] -RRB- cord-019051-gtruu1op 274 79 ) ) -RRB- cord-019051-gtruu1op 274 80 . . . cord-019051-gtruu1op 275 1 The the DT cord-019051-gtruu1op 275 2 replication replication NN cord-019051-gtruu1op 275 3 of of IN cord-019051-gtruu1op 275 4 PIV PIV NNP cord-019051-gtruu1op 275 5 is be VBZ cord-019051-gtruu1op 275 6 similar similar JJ cord-019051-gtruu1op 275 7 to to IN cord-019051-gtruu1op 275 8 that that DT cord-019051-gtruu1op 275 9 of of IN cord-019051-gtruu1op 275 10 other other JJ cord-019051-gtruu1op 275 11 paramyxoviruses paramyxovirus NNS cord-019051-gtruu1op 275 12 with with IN cord-019051-gtruu1op 275 13 the the DT cord-019051-gtruu1op 275 14 RNA RNA NNP cord-019051-gtruu1op 275 15 genome genome NN cord-019051-gtruu1op 275 16 serving serve VBG cord-019051-gtruu1op 275 17 as as IN cord-019051-gtruu1op 275 18 a a DT cord-019051-gtruu1op 275 19 template template NN cord-019051-gtruu1op 275 20 for for IN cord-019051-gtruu1op 275 21 the the DT cord-019051-gtruu1op 275 22 transcription transcription NN cord-019051-gtruu1op 275 23 of of IN cord-019051-gtruu1op 275 24 the the DT cord-019051-gtruu1op 275 25 mRNAs mRNAs NNPS cord-019051-gtruu1op 275 26 . . . cord-019051-gtruu1op 276 1 Binding bind VBG cord-019051-gtruu1op 276 2 of of IN cord-019051-gtruu1op 276 3 the the DT cord-019051-gtruu1op 276 4 HN HN NNP cord-019051-gtruu1op 276 5 glycoprotein glycoprotein NN cord-019051-gtruu1op 276 6 to to IN cord-019051-gtruu1op 276 7 its -PRON- PRP$ cord-019051-gtruu1op 276 8 cell cell NN cord-019051-gtruu1op 276 9 receptor receptor NN cord-019051-gtruu1op 276 10 initiates initiate VBZ cord-019051-gtruu1op 276 11 the the DT cord-019051-gtruu1op 276 12 infection infection NN cord-019051-gtruu1op 276 13 [ [ -LRB- cord-019051-gtruu1op 276 14 98 98 CD cord-019051-gtruu1op 276 15 ] ] -RRB- cord-019051-gtruu1op 276 16 . . . cord-019051-gtruu1op 277 1 In in IN cord-019051-gtruu1op 277 2 addition addition NN cord-019051-gtruu1op 277 3 to to IN cord-019051-gtruu1op 277 4 having have VBG cord-019051-gtruu1op 277 5 this this DT cord-019051-gtruu1op 277 6 function function NN cord-019051-gtruu1op 277 7 , , , cord-019051-gtruu1op 277 8 HN HN NNP cord-019051-gtruu1op 277 9 is be VBZ cord-019051-gtruu1op 277 10 thought think VBN cord-019051-gtruu1op 277 11 to to TO cord-019051-gtruu1op 277 12 enhance enhance VB cord-019051-gtruu1op 277 13 the the DT cord-019051-gtruu1op 277 14 fusion fusion NN cord-019051-gtruu1op 277 15 activity activity NN cord-019051-gtruu1op 277 16 of of IN cord-019051-gtruu1op 277 17 F F NNP cord-019051-gtruu1op 277 18 , , , cord-019051-gtruu1op 277 19 which which WDT cord-019051-gtruu1op 277 20 , , , cord-019051-gtruu1op 277 21 following follow VBG cord-019051-gtruu1op 277 22 virus virus NN cord-019051-gtruu1op 277 23 attachment attachment NN cord-019051-gtruu1op 277 24 to to IN cord-019051-gtruu1op 277 25 the the DT cord-019051-gtruu1op 277 26 host host NN cord-019051-gtruu1op 277 27 cell cell NN cord-019051-gtruu1op 277 28 , , , cord-019051-gtruu1op 277 29 mediates mediate VBZ cord-019051-gtruu1op 277 30 the the DT cord-019051-gtruu1op 277 31 fusion fusion NN cord-019051-gtruu1op 277 32 of of IN cord-019051-gtruu1op 277 33 virus virus NN cord-019051-gtruu1op 277 34 and and CC cord-019051-gtruu1op 277 35 subsequent subsequent JJ cord-019051-gtruu1op 277 36 penetration penetration NN cord-019051-gtruu1op 277 37 . . . cord-019051-gtruu1op 278 1 F F NNP cord-019051-gtruu1op 278 2 also also RB cord-019051-gtruu1op 278 3 mediates mediate VBZ cord-019051-gtruu1op 278 4 fusion fusion NN cord-019051-gtruu1op 278 5 of of IN cord-019051-gtruu1op 278 6 infected infected JJ cord-019051-gtruu1op 278 7 and and CC cord-019051-gtruu1op 278 8 uninfected uninfected JJ cord-019051-gtruu1op 278 9 cells cell NNS cord-019051-gtruu1op 278 10 , , , cord-019051-gtruu1op 278 11 allowing allow VBG cord-019051-gtruu1op 278 12 virus virus NN cord-019051-gtruu1op 278 13 to to TO cord-019051-gtruu1op 278 14 spread spread VB cord-019051-gtruu1op 278 15 . . . cord-019051-gtruu1op 279 1 F F NNP cord-019051-gtruu1op 279 2 is be VBZ cord-019051-gtruu1op 279 3 synthesized synthesize VBN cord-019051-gtruu1op 279 4 as as IN cord-019051-gtruu1op 279 5 an an DT cord-019051-gtruu1op 279 6 inactive inactive JJ cord-019051-gtruu1op 279 7 precursor precursor NN cord-019051-gtruu1op 279 8 ( ( -LRB- cord-019051-gtruu1op 279 9 F F NNP cord-019051-gtruu1op 279 10 0 0 CD cord-019051-gtruu1op 279 11 ) ) -RRB- cord-019051-gtruu1op 279 12 that that WDT cord-019051-gtruu1op 279 13 is be VBZ cord-019051-gtruu1op 279 14 post post JJ cord-019051-gtruu1op 279 15 - - JJ cord-019051-gtruu1op 279 16 translationally translationally RB cord-019051-gtruu1op 279 17 cleaved cleave VBN cord-019051-gtruu1op 279 18 by by IN cord-019051-gtruu1op 279 19 a a DT cord-019051-gtruu1op 279 20 host host NN cord-019051-gtruu1op 279 21 cell cell NN cord-019051-gtruu1op 279 22 protease protease NN cord-019051-gtruu1op 279 23 to to TO cord-019051-gtruu1op 279 24 yield yield VB cord-019051-gtruu1op 279 25 two two CD cord-019051-gtruu1op 279 26 subunits subunit NNS cord-019051-gtruu1op 279 27 , , , cord-019051-gtruu1op 279 28 F F NNP cord-019051-gtruu1op 279 29 1 1 CD cord-019051-gtruu1op 279 30 and and CC cord-019051-gtruu1op 279 31 F F NNP cord-019051-gtruu1op 279 32 2 2 CD cord-019051-gtruu1op 279 33 that that WDT cord-019051-gtruu1op 279 34 remain remain VBP cord-019051-gtruu1op 279 35 linked link VBN cord-019051-gtruu1op 279 36 by by IN cord-019051-gtruu1op 279 37 a a DT cord-019051-gtruu1op 279 38 disulfide disulfide JJ cord-019051-gtruu1op 279 39 bond bond NN cord-019051-gtruu1op 279 40 [ [ -LRB- cord-019051-gtruu1op 279 41 93 93 CD cord-019051-gtruu1op 279 42 ] ] -RRB- cord-019051-gtruu1op 279 43 . . . cord-019051-gtruu1op 280 1 The the DT cord-019051-gtruu1op 280 2 mucous mucous JJ cord-019051-gtruu1op 280 3 membranes membrane NNS cord-019051-gtruu1op 280 4 of of IN cord-019051-gtruu1op 280 5 the the DT cord-019051-gtruu1op 280 6 upper upper JJ cord-019051-gtruu1op 280 7 respiratory respiratory JJ cord-019051-gtruu1op 280 8 tract tract NN cord-019051-gtruu1op 280 9 are be VBP cord-019051-gtruu1op 280 10 the the DT cord-019051-gtruu1op 280 11 common common JJ cord-019051-gtruu1op 280 12 sites site NNS cord-019051-gtruu1op 280 13 of of IN cord-019051-gtruu1op 280 14 infection infection NN cord-019051-gtruu1op 280 15 . . . cord-019051-gtruu1op 281 1 Prominent prominent JJ cord-019051-gtruu1op 281 2 clinical clinical JJ cord-019051-gtruu1op 281 3 symptoms symptom NNS cord-019051-gtruu1op 281 4 of of IN cord-019051-gtruu1op 281 5 HPIV HPIV NNP cord-019051-gtruu1op 281 6 infection infection NN cord-019051-gtruu1op 281 7 can can MD cord-019051-gtruu1op 281 8 be be VB cord-019051-gtruu1op 281 9 characterized characterize VBN cord-019051-gtruu1op 281 10 by by IN cord-019051-gtruu1op 281 11 rhinitis rhinitis NN cord-019051-gtruu1op 281 12 , , , cord-019051-gtruu1op 281 13 pharyngitis pharyngitis NN cord-019051-gtruu1op 281 14 and and CC cord-019051-gtruu1op 281 15 bronchitis bronchitis NN cord-019051-gtruu1op 281 16 . . . cord-019051-gtruu1op 282 1 The the DT cord-019051-gtruu1op 282 2 incubation incubation NN cord-019051-gtruu1op 282 3 period period NN cord-019051-gtruu1op 282 4 is be VBZ cord-019051-gtruu1op 282 5 about about RB cord-019051-gtruu1op 282 6 4 4 CD cord-019051-gtruu1op 282 7 days day NNS cord-019051-gtruu1op 282 8 [ [ -LRB- cord-019051-gtruu1op 282 9 95 95 CD cord-019051-gtruu1op 282 10 ] ] -RRB- cord-019051-gtruu1op 282 11 . . . cord-019051-gtruu1op 283 1 Coughing coughing NN cord-019051-gtruu1op 283 2 , , , cord-019051-gtruu1op 283 3 hoarseness hoarseness NN cord-019051-gtruu1op 283 4 and and CC cord-019051-gtruu1op 283 5 fever fever NN cord-019051-gtruu1op 283 6 that that WDT cord-019051-gtruu1op 283 7 last last JJ cord-019051-gtruu1op 283 8 for for IN cord-019051-gtruu1op 283 9 approximately approximately RB cord-019051-gtruu1op 283 10 2 2 CD cord-019051-gtruu1op 283 11 - - SYM cord-019051-gtruu1op 283 12 3 3 CD cord-019051-gtruu1op 283 13 days day NNS cord-019051-gtruu1op 283 14 are be VBP cord-019051-gtruu1op 283 15 frequent frequent JJ cord-019051-gtruu1op 283 16 . . . cord-019051-gtruu1op 284 1 Involvement involvement NN cord-019051-gtruu1op 284 2 of of IN cord-019051-gtruu1op 284 3 the the DT cord-019051-gtruu1op 284 4 trachea trachea NN cord-019051-gtruu1op 284 5 results result NNS cord-019051-gtruu1op 284 6 in in IN cord-019051-gtruu1op 284 7 croup croup NN cord-019051-gtruu1op 284 8 and and CC cord-019051-gtruu1op 284 9 extension extension NN cord-019051-gtruu1op 284 10 to to IN cord-019051-gtruu1op 284 11 the the DT cord-019051-gtruu1op 284 12 lower low JJR cord-019051-gtruu1op 284 13 respiratory respiratory JJ cord-019051-gtruu1op 284 14 tract tract NN cord-019051-gtruu1op 284 15 may may MD cord-019051-gtruu1op 284 16 lead lead VB cord-019051-gtruu1op 284 17 to to IN cord-019051-gtruu1op 284 18 pneumonia pneumonia NN cord-019051-gtruu1op 284 19 . . . cord-019051-gtruu1op 285 1 Severe severe JJ cord-019051-gtruu1op 285 2 disease disease NN cord-019051-gtruu1op 285 3 characterized characterize VBN cord-019051-gtruu1op 285 4 as as IN cord-019051-gtruu1op 285 5 bronchopneumonia bronchopneumonia NN cord-019051-gtruu1op 285 6 or or CC cord-019051-gtruu1op 285 7 bronchiolitis bronchiolitis NN cord-019051-gtruu1op 285 8 has have VBZ cord-019051-gtruu1op 285 9 been be VBN cord-019051-gtruu1op 285 10 observed observe VBN cord-019051-gtruu1op 285 11 with with IN cord-019051-gtruu1op 285 12 HPIV3 hpiv3 NN cord-019051-gtruu1op 285 13 infections infection NNS cord-019051-gtruu1op 285 14 [ [ -LRB- cord-019051-gtruu1op 285 15 93 93 CD cord-019051-gtruu1op 285 16 ] ] -RRB- cord-019051-gtruu1op 285 17 [ [ -LRB- cord-019051-gtruu1op 285 18 94 94 CD cord-019051-gtruu1op 285 19 ] ] -RRB- cord-019051-gtruu1op 285 20 [ [ -LRB- cord-019051-gtruu1op 285 21 95 95 CD cord-019051-gtruu1op 285 22 ] ] -RRB- cord-019051-gtruu1op 285 23 . . . cord-019051-gtruu1op 286 1 Specific specific JJ cord-019051-gtruu1op 286 2 virus virus NN cord-019051-gtruu1op 286 3 and and CC cord-019051-gtruu1op 286 4 host host NN cord-019051-gtruu1op 286 5 properties property NNS cord-019051-gtruu1op 286 6 that that WDT cord-019051-gtruu1op 286 7 determine determine VBP cord-019051-gtruu1op 286 8 the the DT cord-019051-gtruu1op 286 9 severity severity NN cord-019051-gtruu1op 286 10 of of IN cord-019051-gtruu1op 286 11 HPIVrelated hpivrelate VBN cord-019051-gtruu1op 286 12 disease disease NN cord-019051-gtruu1op 286 13 are be VBP cord-019051-gtruu1op 286 14 not not RB cord-019051-gtruu1op 286 15 yet yet RB cord-019051-gtruu1op 286 16 understood understand VBN cord-019051-gtruu1op 286 17 . . . cord-019051-gtruu1op 287 1 Infection infection NN cord-019051-gtruu1op 287 2 with with IN cord-019051-gtruu1op 287 3 PIV PIV NNP cord-019051-gtruu1op 287 4 induces induce VBZ cord-019051-gtruu1op 287 5 an an DT cord-019051-gtruu1op 287 6 immune immune JJ cord-019051-gtruu1op 287 7 response response NN cord-019051-gtruu1op 287 8 to to IN cord-019051-gtruu1op 287 9 HN HN NNP cord-019051-gtruu1op 287 10 and and CC cord-019051-gtruu1op 287 11 F. F. NNP cord-019051-gtruu1op 287 12 Neutralizing neutralize VBG cord-019051-gtruu1op 287 13 antibodies antibody NNS cord-019051-gtruu1op 287 14 to to IN cord-019051-gtruu1op 287 15 PIV PIV NNP cord-019051-gtruu1op 287 16 correlate correlate VB cord-019051-gtruu1op 287 17 with with IN cord-019051-gtruu1op 287 18 partial partial JJ cord-019051-gtruu1op 287 19 resistance resistance NN cord-019051-gtruu1op 287 20 to to IN cord-019051-gtruu1op 287 21 infection infection NN cord-019051-gtruu1op 287 22 or or CC cord-019051-gtruu1op 287 23 clinical clinical JJ cord-019051-gtruu1op 287 24 symptoms symptom NNS cord-019051-gtruu1op 287 25 but but CC cord-019051-gtruu1op 287 26 usually usually RB cord-019051-gtruu1op 287 27 do do VBP cord-019051-gtruu1op 287 28 not not RB cord-019051-gtruu1op 287 29 prevent prevent VB cord-019051-gtruu1op 287 30 re re NN cord-019051-gtruu1op 287 31 - - NN cord-019051-gtruu1op 287 32 infection infection NN cord-019051-gtruu1op 287 33 [ [ -LRB- cord-019051-gtruu1op 287 34 99 99 CD cord-019051-gtruu1op 287 35 ] ] -RRB- cord-019051-gtruu1op 287 36 . . . cord-019051-gtruu1op 288 1 Secretory secretory JJ cord-019051-gtruu1op 288 2 IgA iga NN cord-019051-gtruu1op 288 3 neutralizing neutralize VBG cord-019051-gtruu1op 288 4 antibodies antibody NNS cord-019051-gtruu1op 288 5 are be VBP cord-019051-gtruu1op 288 6 more more RBR cord-019051-gtruu1op 288 7 important important JJ cord-019051-gtruu1op 288 8 in in IN cord-019051-gtruu1op 288 9 adults adult NNS cord-019051-gtruu1op 288 10 than than IN cord-019051-gtruu1op 288 11 in in IN cord-019051-gtruu1op 288 12 children child NNS cord-019051-gtruu1op 288 13 [ [ -LRB- cord-019051-gtruu1op 288 14 100 100 CD cord-019051-gtruu1op 288 15 ] ] -RRB- cord-019051-gtruu1op 288 16 . . . cord-019051-gtruu1op 289 1 As as IN cord-019051-gtruu1op 289 2 mentioned mention VBN cord-019051-gtruu1op 289 3 above above RB cord-019051-gtruu1op 289 4 , , , cord-019051-gtruu1op 289 5 the the DT cord-019051-gtruu1op 289 6 HPIVs hpiv NNS cord-019051-gtruu1op 289 7 are be VBP cord-019051-gtruu1op 289 8 important important JJ cord-019051-gtruu1op 289 9 causes cause NNS cord-019051-gtruu1op 289 10 of of IN cord-019051-gtruu1op 289 11 respiratory respiratory JJ cord-019051-gtruu1op 289 12 tract tract NN cord-019051-gtruu1op 289 13 diseases disease NNS cord-019051-gtruu1op 289 14 in in IN cord-019051-gtruu1op 289 15 infants infant NNS cord-019051-gtruu1op 289 16 and and CC cord-019051-gtruu1op 289 17 children child NNS cord-019051-gtruu1op 289 18 . . . cord-019051-gtruu1op 290 1 Epidemics epidemic NNS cord-019051-gtruu1op 290 2 of of IN cord-019051-gtruu1op 290 3 HPIV3 hpiv3 NN cord-019051-gtruu1op 290 4 usually usually RB cord-019051-gtruu1op 290 5 occur occur VBP cord-019051-gtruu1op 290 6 in in IN cord-019051-gtruu1op 290 7 the the DT cord-019051-gtruu1op 290 8 early early JJ cord-019051-gtruu1op 290 9 spring spring NN cord-019051-gtruu1op 290 10 [ [ -LRB- cord-019051-gtruu1op 290 11 101 101 CD cord-019051-gtruu1op 290 12 ] ] -RRB- cord-019051-gtruu1op 290 13 . . . cord-019051-gtruu1op 291 1 Viruses virus NNS cord-019051-gtruu1op 291 2 do do VBP cord-019051-gtruu1op 291 3 not not RB cord-019051-gtruu1op 291 4 persist persist VB cord-019051-gtruu1op 291 5 for for IN cord-019051-gtruu1op 291 6 a a DT cord-019051-gtruu1op 291 7 long long JJ cord-019051-gtruu1op 291 8 time time NN cord-019051-gtruu1op 291 9 in in IN cord-019051-gtruu1op 291 10 the the DT cord-019051-gtruu1op 291 11 environment environment NN cord-019051-gtruu1op 291 12 [ [ -LRB- cord-019051-gtruu1op 291 13 93 93 CD cord-019051-gtruu1op 291 14 ] ] -RRB- cord-019051-gtruu1op 291 15 . . . cord-019051-gtruu1op 292 1 The the DT cord-019051-gtruu1op 292 2 seasonal seasonal JJ cord-019051-gtruu1op 292 3 peak peak NN cord-019051-gtruu1op 292 4 of of IN cord-019051-gtruu1op 292 5 HPIV1 HPIV1 NNP cord-019051-gtruu1op 292 6 and and CC cord-019051-gtruu1op 292 7 2 2 CD cord-019051-gtruu1op 292 8 infections infection NNS cord-019051-gtruu1op 292 9 is be VBZ cord-019051-gtruu1op 292 10 reflected reflect VBN cord-019051-gtruu1op 292 11 in in IN cord-019051-gtruu1op 292 12 the the DT cord-019051-gtruu1op 292 13 seasonality seasonality NN cord-019051-gtruu1op 292 14 of of IN cord-019051-gtruu1op 292 15 croup croup NN cord-019051-gtruu1op 292 16 , , , cord-019051-gtruu1op 292 17 which which WDT cord-019051-gtruu1op 292 18 is be VBZ cord-019051-gtruu1op 292 19 the the DT cord-019051-gtruu1op 292 20 highest high JJS cord-019051-gtruu1op 292 21 in in IN cord-019051-gtruu1op 292 22 autumn autumn NN cord-019051-gtruu1op 292 23 in in IN cord-019051-gtruu1op 292 24 the the DT cord-019051-gtruu1op 292 25 USA USA NNP cord-019051-gtruu1op 292 26 [ [ -LRB- cord-019051-gtruu1op 292 27 102 102 CD cord-019051-gtruu1op 292 28 ] ] -RRB- cord-019051-gtruu1op 292 29 . . . cord-019051-gtruu1op 293 1 Croup croup NN cord-019051-gtruu1op 293 2 during during IN cord-019051-gtruu1op 293 3 the the DT cord-019051-gtruu1op 293 4 winter winter NN cord-019051-gtruu1op 293 5 months month NNS cord-019051-gtruu1op 293 6 is be VBZ cord-019051-gtruu1op 293 7 more more RBR cord-019051-gtruu1op 293 8 likely likely JJ cord-019051-gtruu1op 293 9 to to TO cord-019051-gtruu1op 293 10 be be VB cord-019051-gtruu1op 293 11 caused cause VBN cord-019051-gtruu1op 293 12 by by IN cord-019051-gtruu1op 293 13 other other JJ cord-019051-gtruu1op 293 14 viruses virus NNS cord-019051-gtruu1op 293 15 , , , cord-019051-gtruu1op 293 16 such such JJ cord-019051-gtruu1op 293 17 as as IN cord-019051-gtruu1op 293 18 influenza influenza NN cord-019051-gtruu1op 293 19 virus virus NN cord-019051-gtruu1op 293 20 or or CC cord-019051-gtruu1op 293 21 RSV RSV NNP cord-019051-gtruu1op 293 22 [ [ -LRB- cord-019051-gtruu1op 293 23 93 93 CD cord-019051-gtruu1op 293 24 ] ] -RRB- cord-019051-gtruu1op 293 25 . . . cord-019051-gtruu1op 294 1 The the DT cord-019051-gtruu1op 294 2 diagnosis diagnosis NN cord-019051-gtruu1op 294 3 of of IN cord-019051-gtruu1op 294 4 PIV PIV NNP cord-019051-gtruu1op 294 5 infection infection NN cord-019051-gtruu1op 294 6 is be VBZ cord-019051-gtruu1op 294 7 mainly mainly RB cord-019051-gtruu1op 294 8 clinical clinical JJ cord-019051-gtruu1op 294 9 , , , cord-019051-gtruu1op 294 10 and and CC cord-019051-gtruu1op 294 11 molecular molecular JJ cord-019051-gtruu1op 294 12 diagnostic diagnostic JJ cord-019051-gtruu1op 294 13 procedures procedure NNS cord-019051-gtruu1op 294 14 are be VBP cord-019051-gtruu1op 294 15 usually usually RB cord-019051-gtruu1op 294 16 not not RB cord-019051-gtruu1op 294 17 performed perform VBN cord-019051-gtruu1op 294 18 . . . cord-019051-gtruu1op 295 1 There there EX cord-019051-gtruu1op 295 2 is be VBZ cord-019051-gtruu1op 295 3 no no DT cord-019051-gtruu1op 295 4 specific specific JJ cord-019051-gtruu1op 295 5 antiviral antiviral JJ cord-019051-gtruu1op 295 6 treatment treatment NN cord-019051-gtruu1op 295 7 against against IN cord-019051-gtruu1op 295 8 PIV PIV NNP cord-019051-gtruu1op 295 9 available available JJ cord-019051-gtruu1op 295 10 , , , cord-019051-gtruu1op 295 11 and and CC cord-019051-gtruu1op 295 12 therapeutic therapeutic JJ cord-019051-gtruu1op 295 13 intervention intervention NN cord-019051-gtruu1op 295 14 is be VBZ cord-019051-gtruu1op 295 15 mainly mainly RB cord-019051-gtruu1op 295 16 targeted target VBN cord-019051-gtruu1op 295 17 against against IN cord-019051-gtruu1op 295 18 symptoms symptom NNS cord-019051-gtruu1op 295 19 of of IN cord-019051-gtruu1op 295 20 croup croup NN cord-019051-gtruu1op 295 21 . . . cord-019051-gtruu1op 296 1 Early early JJ cord-019051-gtruu1op 296 2 treatment treatment NN cord-019051-gtruu1op 296 3 will will MD cord-019051-gtruu1op 296 4 reduce reduce VB cord-019051-gtruu1op 296 5 the the DT cord-019051-gtruu1op 296 6 severity severity NN cord-019051-gtruu1op 296 7 of of IN cord-019051-gtruu1op 296 8 the the DT cord-019051-gtruu1op 296 9 symptoms symptom NNS cord-019051-gtruu1op 296 10 , , , cord-019051-gtruu1op 296 11 the the DT cord-019051-gtruu1op 296 12 rates rate NNS cord-019051-gtruu1op 296 13 at at IN cord-019051-gtruu1op 296 14 which which WDT cord-019051-gtruu1op 296 15 patients patient NNS cord-019051-gtruu1op 296 16 return return VBP cord-019051-gtruu1op 296 17 to to IN cord-019051-gtruu1op 296 18 a a DT cord-019051-gtruu1op 296 19 health health NN cord-019051-gtruu1op 296 20 care care NN cord-019051-gtruu1op 296 21 practitioner practitioner NN cord-019051-gtruu1op 296 22 for for IN cord-019051-gtruu1op 296 23 additional additional JJ cord-019051-gtruu1op 296 24 medical medical JJ cord-019051-gtruu1op 296 25 attention attention NN cord-019051-gtruu1op 296 26 , , , cord-019051-gtruu1op 296 27 visits visit NNS cord-019051-gtruu1op 296 28 to to IN cord-019051-gtruu1op 296 29 the the DT cord-019051-gtruu1op 296 30 emergency emergency NN cord-019051-gtruu1op 296 31 department department NN cord-019051-gtruu1op 296 32 , , , cord-019051-gtruu1op 296 33 and and CC cord-019051-gtruu1op 296 34 admission admission NN cord-019051-gtruu1op 296 35 to to IN cord-019051-gtruu1op 296 36 the the DT cord-019051-gtruu1op 296 37 hospital hospital NN cord-019051-gtruu1op 296 38 [ [ -LRB- cord-019051-gtruu1op 296 39 103 103 CD cord-019051-gtruu1op 296 40 ] ] -RRB- cord-019051-gtruu1op 296 41 . . . cord-019051-gtruu1op 297 1 Effective effective JJ cord-019051-gtruu1op 297 2 vaccines vaccine NNS cord-019051-gtruu1op 297 3 are be VBP cord-019051-gtruu1op 297 4 currently currently RB cord-019051-gtruu1op 297 5 not not RB cord-019051-gtruu1op 297 6 available available JJ cord-019051-gtruu1op 297 7 . . . cord-019051-gtruu1op 298 1 Attenuated attenuated JJ cord-019051-gtruu1op 298 2 strains strain NNS cord-019051-gtruu1op 298 3 have have VBP cord-019051-gtruu1op 298 4 been be VBN cord-019051-gtruu1op 298 5 studied study VBN cord-019051-gtruu1op 298 6 and and CC cord-019051-gtruu1op 298 7 a a DT cord-019051-gtruu1op 298 8 virosomal virosomal JJ cord-019051-gtruu1op 298 9 formulation formulation NN cord-019051-gtruu1op 298 10 of of IN cord-019051-gtruu1op 298 11 an an DT cord-019051-gtruu1op 298 12 HPIV3 hpiv3 NN cord-019051-gtruu1op 298 13 vaccine vaccine NN cord-019051-gtruu1op 298 14 is be VBZ cord-019051-gtruu1op 298 15 currently currently RB cord-019051-gtruu1op 298 16 under under IN cord-019051-gtruu1op 298 17 development development NN cord-019051-gtruu1op 298 18 [ [ -LRB- cord-019051-gtruu1op 298 19 92 92 CD cord-019051-gtruu1op 298 20 ] ] -RRB- cord-019051-gtruu1op 298 21 . . . cord-019051-gtruu1op 299 1 The the DT cord-019051-gtruu1op 299 2 National National NNP cord-019051-gtruu1op 299 3 Institute Institute NNP cord-019051-gtruu1op 299 4 of of IN cord-019051-gtruu1op 299 5 Allergy Allergy NNP cord-019051-gtruu1op 299 6 and and CC cord-019051-gtruu1op 299 7 Infectious Infectious NNP cord-019051-gtruu1op 299 8 Diseases Diseases NNPS cord-019051-gtruu1op 299 9 ( ( -LRB- cord-019051-gtruu1op 299 10 NIAID NIAID NNP cord-019051-gtruu1op 299 11 ) ) -RRB- cord-019051-gtruu1op 299 12 is be VBZ cord-019051-gtruu1op 299 13 studying study VBG cord-019051-gtruu1op 299 14 the the DT cord-019051-gtruu1op 299 15 safety safety NN cord-019051-gtruu1op 299 16 and and CC cord-019051-gtruu1op 299 17 immunogenicity immunogenicity NN cord-019051-gtruu1op 299 18 of of IN cord-019051-gtruu1op 299 19 a a DT cord-019051-gtruu1op 299 20 recombinant recombinant JJ cord-019051-gtruu1op 299 21 live live RB cord-019051-gtruu1op 299 22 - - HYPH cord-019051-gtruu1op 299 23 attenuated attenuated JJ cord-019051-gtruu1op 299 24 chimeric chimeric JJ cord-019051-gtruu1op 299 25 bovine bovine JJ cord-019051-gtruu1op 299 26 / / SYM cord-019051-gtruu1op 299 27 human human JJ cord-019051-gtruu1op 299 28 parainfluenza parainfluenza NNP cord-019051-gtruu1op 299 29 type type NNP cord-019051-gtruu1op 299 30 3 3 CD cord-019051-gtruu1op 299 31 virus virus NN cord-019051-gtruu1op 299 32 , , , cord-019051-gtruu1op 299 33 rB/ rB/ NNP cord-019051-gtruu1op 299 34 hPIV3 hpiv3 NN cord-019051-gtruu1op 299 35 , , , cord-019051-gtruu1op 299 36 vaccine vaccine NN cord-019051-gtruu1op 299 37 in in IN cord-019051-gtruu1op 299 38 a a DT cord-019051-gtruu1op 299 39 Phase phase NN cord-019051-gtruu1op 299 40 I -PRON- PRP cord-019051-gtruu1op 299 41 study study VBP cord-019051-gtruu1op 299 42 . . . cord-019051-gtruu1op 300 1 The the DT cord-019051-gtruu1op 300 2 test test NN cord-019051-gtruu1op 300 3 vaccine vaccine NN cord-019051-gtruu1op 300 4 is be VBZ cord-019051-gtruu1op 300 5 delivered deliver VBN cord-019051-gtruu1op 300 6 as as IN cord-019051-gtruu1op 300 7 nose nose NN cord-019051-gtruu1op 300 8 drops drop VBZ cord-019051-gtruu1op 300 9 to to IN cord-019051-gtruu1op 300 10 adults adult NNS cord-019051-gtruu1op 300 11 18 18 CD cord-019051-gtruu1op 300 12 - - SYM cord-019051-gtruu1op 300 13 49 49 CD cord-019051-gtruu1op 300 14 years year NNS cord-019051-gtruu1op 300 15 of of IN cord-019051-gtruu1op 300 16 age age NN cord-019051-gtruu1op 300 17 , , , cord-019051-gtruu1op 300 18 HPIV3-seropositive hpiv3-seropositive CD cord-019051-gtruu1op 300 19 children child NNS cord-019051-gtruu1op 300 20 15 15 CD cord-019051-gtruu1op 300 21 - - SYM cord-019051-gtruu1op 300 22 59 59 CD cord-019051-gtruu1op 300 23 months month NNS cord-019051-gtruu1op 300 24 of of IN cord-019051-gtruu1op 300 25 age age NN cord-019051-gtruu1op 300 26 , , , cord-019051-gtruu1op 300 27 and and CC cord-019051-gtruu1op 300 28 HPIV3-seronegative hpiv3-seronegative CD cord-019051-gtruu1op 300 29 infants infant NNS cord-019051-gtruu1op 300 30 and and CC cord-019051-gtruu1op 300 31 children child NNS cord-019051-gtruu1op 300 32 6 6 CD cord-019051-gtruu1op 300 33 - - SYM cord-019051-gtruu1op 300 34 36 36 CD cord-019051-gtruu1op 300 35 months month NNS cord-019051-gtruu1op 300 36 of of IN cord-019051-gtruu1op 300 37 age age NN cord-019051-gtruu1op 300 38 [ [ -LRB- cord-019051-gtruu1op 300 39 104 104 CD cord-019051-gtruu1op 300 40 ] ] -RRB- cord-019051-gtruu1op 300 41 . . . cord-019051-gtruu1op 301 1 HPIV HPIV NNP cord-019051-gtruu1op 301 2 vaccines vaccine NNS cord-019051-gtruu1op 301 3 are be VBP cord-019051-gtruu1op 301 4 also also RB cord-019051-gtruu1op 301 5 developed develop VBN cord-019051-gtruu1op 301 6 by by IN cord-019051-gtruu1op 301 7 some some DT cord-019051-gtruu1op 301 8 companies company NNS cord-019051-gtruu1op 301 9 [ [ -LRB- cord-019051-gtruu1op 301 10 105 105 CD cord-019051-gtruu1op 301 11 ] ] -RRB- cord-019051-gtruu1op 301 12 . . . cord-019051-gtruu1op 302 1 Adenoviruses adenovirus NNS cord-019051-gtruu1op 302 2 cause cause VBP cord-019051-gtruu1op 302 3 infections infection NNS cord-019051-gtruu1op 302 4 of of IN cord-019051-gtruu1op 302 5 the the DT cord-019051-gtruu1op 302 6 respiratory respiratory JJ cord-019051-gtruu1op 302 7 and and CC cord-019051-gtruu1op 302 8 gastrointestinal gastrointestinal JJ cord-019051-gtruu1op 302 9 tract tract NN cord-019051-gtruu1op 302 10 , , , cord-019051-gtruu1op 302 11 kidney kidney NN cord-019051-gtruu1op 302 12 , , , cord-019051-gtruu1op 302 13 eye eye NN cord-019051-gtruu1op 302 14 and and CC cord-019051-gtruu1op 302 15 other other JJ cord-019051-gtruu1op 302 16 organs organ NNS cord-019051-gtruu1op 302 17 , , , cord-019051-gtruu1op 302 18 the the DT cord-019051-gtruu1op 302 19 latter latter JJ cord-019051-gtruu1op 302 20 mostly mostly RB cord-019051-gtruu1op 302 21 as as IN cord-019051-gtruu1op 302 22 a a DT cord-019051-gtruu1op 302 23 consequence consequence NN cord-019051-gtruu1op 302 24 of of IN cord-019051-gtruu1op 302 25 immunosuppression immunosuppression NN cord-019051-gtruu1op 302 26 [ [ -LRB- cord-019051-gtruu1op 302 27 106 106 CD cord-019051-gtruu1op 302 28 ] ] -RRB- cord-019051-gtruu1op 302 29 . . . cord-019051-gtruu1op 303 1 They -PRON- PRP cord-019051-gtruu1op 303 2 are be VBP cord-019051-gtruu1op 303 3 known know VBN cord-019051-gtruu1op 303 4 to to TO cord-019051-gtruu1op 303 5 frequently frequently RB cord-019051-gtruu1op 303 6 cause cause VB cord-019051-gtruu1op 303 7 respiratory respiratory JJ cord-019051-gtruu1op 303 8 infections infection NNS cord-019051-gtruu1op 303 9 among among IN cord-019051-gtruu1op 303 10 people people NNS cord-019051-gtruu1op 303 11 in in IN cord-019051-gtruu1op 303 12 institutional institutional JJ cord-019051-gtruu1op 303 13 environments environment NNS cord-019051-gtruu1op 303 14 -outbreaks -outbreaks : cord-019051-gtruu1op 303 15 among among IN cord-019051-gtruu1op 303 16 children child NNS cord-019051-gtruu1op 303 17 are be VBP cord-019051-gtruu1op 303 18 reported report VBN cord-019051-gtruu1op 303 19 at at IN cord-019051-gtruu1op 303 20 boarding board VBG cord-019051-gtruu1op 303 21 schools school NNS cord-019051-gtruu1op 303 22 and and CC cord-019051-gtruu1op 303 23 summer summer NN cord-019051-gtruu1op 303 24 camps camp NNS cord-019051-gtruu1op 303 25 [ [ -LRB- cord-019051-gtruu1op 303 26 107 107 CD cord-019051-gtruu1op 303 27 ] ] -RRB- cord-019051-gtruu1op 303 28 . . . cord-019051-gtruu1op 304 1 Outbreaks outbreak NNS cord-019051-gtruu1op 304 2 have have VBP cord-019051-gtruu1op 304 3 also also RB cord-019051-gtruu1op 304 4 been be VBN cord-019051-gtruu1op 304 5 reported report VBN cord-019051-gtruu1op 304 6 in in IN cord-019051-gtruu1op 304 7 military military JJ cord-019051-gtruu1op 304 8 camps camp NNS cord-019051-gtruu1op 304 9 [ [ -LRB- cord-019051-gtruu1op 304 10 108 108 CD cord-019051-gtruu1op 304 11 ] ] -RRB- cord-019051-gtruu1op 304 12 . . . cord-019051-gtruu1op 305 1 Most Most JJS cord-019051-gtruu1op 305 2 infections infection NNS cord-019051-gtruu1op 305 3 with with IN cord-019051-gtruu1op 305 4 adenovirus adenovirus NN cord-019051-gtruu1op 305 5 result result NN cord-019051-gtruu1op 305 6 in in IN cord-019051-gtruu1op 305 7 infections infection NNS cord-019051-gtruu1op 305 8 of of IN cord-019051-gtruu1op 305 9 the the DT cord-019051-gtruu1op 305 10 upper upper JJ cord-019051-gtruu1op 305 11 respiratory respiratory JJ cord-019051-gtruu1op 305 12 tract tract NN cord-019051-gtruu1op 305 13 . . . cord-019051-gtruu1op 306 1 In in IN cord-019051-gtruu1op 306 2 addition addition NN cord-019051-gtruu1op 306 3 , , , cord-019051-gtruu1op 306 4 adenovirus adenovirus NN cord-019051-gtruu1op 306 5 infections infection NNS cord-019051-gtruu1op 306 6 may may MD cord-019051-gtruu1op 306 7 result result VB cord-019051-gtruu1op 306 8 in in IN cord-019051-gtruu1op 306 9 conjunctivitis conjunctivitis NN cord-019051-gtruu1op 306 10 , , , cord-019051-gtruu1op 306 11 tonsillitis tonsillitis NN cord-019051-gtruu1op 306 12 , , , cord-019051-gtruu1op 306 13 ear ear NN cord-019051-gtruu1op 306 14 infection infection NN cord-019051-gtruu1op 306 15 or or CC cord-019051-gtruu1op 306 16 croup croup NN cord-019051-gtruu1op 306 17 [ [ -LRB- cord-019051-gtruu1op 306 18 106 106 CD cord-019051-gtruu1op 306 19 ] ] -RRB- cord-019051-gtruu1op 307 1 [ [ -LRB- cord-019051-gtruu1op 307 2 107 107 CD cord-019051-gtruu1op 307 3 ] ] -RRB- cord-019051-gtruu1op 308 1 [ [ -LRB- cord-019051-gtruu1op 308 2 108 108 CD cord-019051-gtruu1op 308 3 ] ] -RRB- cord-019051-gtruu1op 308 4 [ [ -LRB- cord-019051-gtruu1op 308 5 109 109 CD cord-019051-gtruu1op 308 6 ] ] -RRB- cord-019051-gtruu1op 308 7 . . . cord-019051-gtruu1op 309 1 Adenoviruses adenovirus NNS cord-019051-gtruu1op 309 2 are be VBP cord-019051-gtruu1op 309 3 responsible responsible JJ cord-019051-gtruu1op 309 4 for for IN cord-019051-gtruu1op 309 5 approximately approximately RB cord-019051-gtruu1op 309 6 5 5 CD cord-019051-gtruu1op 309 7 % % NN cord-019051-gtruu1op 309 8 of of IN cord-019051-gtruu1op 309 9 acute acute JJ cord-019051-gtruu1op 309 10 respiratory respiratory JJ cord-019051-gtruu1op 309 11 infections infection NNS cord-019051-gtruu1op 309 12 in in IN cord-019051-gtruu1op 309 13 children child NNS cord-019051-gtruu1op 309 14 under under IN cord-019051-gtruu1op 309 15 the the DT cord-019051-gtruu1op 309 16 age age NN cord-019051-gtruu1op 309 17 of of IN cord-019051-gtruu1op 309 18 5 5 CD cord-019051-gtruu1op 309 19 [ [ -LRB- cord-019051-gtruu1op 309 20 107 107 CD cord-019051-gtruu1op 309 21 , , , cord-019051-gtruu1op 309 22 109 109 CD cord-019051-gtruu1op 309 23 ] ] -RRB- cord-019051-gtruu1op 309 24 _SP cord-019051-gtruu1op 309 25 Adenoviruses adenovirus NNS cord-019051-gtruu1op 309 26 belong belong VBP cord-019051-gtruu1op 309 27 to to IN cord-019051-gtruu1op 309 28 the the DT cord-019051-gtruu1op 309 29 family family NN cord-019051-gtruu1op 309 30 Adenoviridae Adenoviridae NNP cord-019051-gtruu1op 309 31 , , , cord-019051-gtruu1op 309 32 genus genus NN cord-019051-gtruu1op 309 33 Mastadenovirus Mastadenovirus NNP cord-019051-gtruu1op 309 34 . . . cord-019051-gtruu1op 310 1 There there EX cord-019051-gtruu1op 310 2 are be VBP cord-019051-gtruu1op 310 3 6 6 CD cord-019051-gtruu1op 310 4 species specie NNS cord-019051-gtruu1op 310 5 including include VBG cord-019051-gtruu1op 310 6 human human JJ cord-019051-gtruu1op 310 7 adenovirus adenovirus NN cord-019051-gtruu1op 310 8 A A NNP cord-019051-gtruu1op 310 9 - - HYPH cord-019051-gtruu1op 310 10 F f NN cord-019051-gtruu1op 310 11 with with IN cord-019051-gtruu1op 310 12 51 51 CD cord-019051-gtruu1op 310 13 immunologically immunologically RB cord-019051-gtruu1op 310 14 distinct distinct JJ cord-019051-gtruu1op 310 15 human human JJ cord-019051-gtruu1op 310 16 adenovirus adenovirus NN cord-019051-gtruu1op 310 17 serotypes serotype NNS cord-019051-gtruu1op 310 18 [ [ -LRB- cord-019051-gtruu1op 310 19 110 110 CD cord-019051-gtruu1op 310 20 ] ] -RRB- cord-019051-gtruu1op 310 21 . . . cord-019051-gtruu1op 311 1 The the DT cord-019051-gtruu1op 311 2 most most RBS cord-019051-gtruu1op 311 3 common common JJ cord-019051-gtruu1op 311 4 human human JJ cord-019051-gtruu1op 311 5 adenoviral adenoviral JJ cord-019051-gtruu1op 311 6 pathogens pathogen NNS cord-019051-gtruu1op 311 7 belong belong VBP cord-019051-gtruu1op 311 8 to to IN cord-019051-gtruu1op 311 9 the the DT cord-019051-gtruu1op 311 10 C C NNP cord-019051-gtruu1op 311 11 adenoviruses adenovirus NNS cord-019051-gtruu1op 311 12 and and CC cord-019051-gtruu1op 311 13 those those DT cord-019051-gtruu1op 311 14 mainly mainly RB cord-019051-gtruu1op 311 15 infect infect VBP cord-019051-gtruu1op 311 16 the the DT cord-019051-gtruu1op 311 17 upper upper JJ cord-019051-gtruu1op 311 18 respiratory respiratory JJ cord-019051-gtruu1op 311 19 tract tract NN cord-019051-gtruu1op 311 20 [ [ -LRB- cord-019051-gtruu1op 311 21 107 107 CD cord-019051-gtruu1op 311 22 ] ] -RRB- cord-019051-gtruu1op 311 23 . . . cord-019051-gtruu1op 312 1 The the DT cord-019051-gtruu1op 312 2 virions virion NNS cord-019051-gtruu1op 312 3 are be VBP cord-019051-gtruu1op 312 4 not not RB cord-019051-gtruu1op 312 5 enveloped envelop VBN cord-019051-gtruu1op 312 6 . . . cord-019051-gtruu1op 313 1 They -PRON- PRP cord-019051-gtruu1op 313 2 consist consist VBP cord-019051-gtruu1op 313 3 of of IN cord-019051-gtruu1op 313 4 a a DT cord-019051-gtruu1op 313 5 capsid capsid NN cord-019051-gtruu1op 313 6 and and CC cord-019051-gtruu1op 313 7 a a DT cord-019051-gtruu1op 313 8 core core NN cord-019051-gtruu1op 313 9 with with IN cord-019051-gtruu1op 313 10 proteins protein NNS cord-019051-gtruu1op 313 11 associated associate VBN cord-019051-gtruu1op 313 12 to to IN cord-019051-gtruu1op 313 13 it -PRON- PRP cord-019051-gtruu1op 313 14 . . . cord-019051-gtruu1op 314 1 The the DT cord-019051-gtruu1op 314 2 icosahedral icosahedral JJ cord-019051-gtruu1op 314 3 capsid capsid NN cord-019051-gtruu1op 314 4 has have VBZ cord-019051-gtruu1op 314 5 a a DT cord-019051-gtruu1op 314 6 diameter diameter NN cord-019051-gtruu1op 314 7 of of IN cord-019051-gtruu1op 314 8 70 70 CD cord-019051-gtruu1op 314 9 - - SYM cord-019051-gtruu1op 314 10 100 100 CD cord-019051-gtruu1op 314 11 nm nm NN cord-019051-gtruu1op 314 12 [ [ -LRB- cord-019051-gtruu1op 314 13 111 111 CD cord-019051-gtruu1op 314 14 , , , cord-019051-gtruu1op 314 15 112 112 CD cord-019051-gtruu1op 314 16 ] ] -RRB- cord-019051-gtruu1op 314 17 . . . cord-019051-gtruu1op 315 1 All all DT cord-019051-gtruu1op 315 2 capsids capsid NNS cord-019051-gtruu1op 315 3 consist consist VBP cord-019051-gtruu1op 315 4 of of IN cord-019051-gtruu1op 315 5 252 252 CD cord-019051-gtruu1op 315 6 capsomers capsomer NNS cord-019051-gtruu1op 315 7 . . . cord-019051-gtruu1op 316 1 The the DT cord-019051-gtruu1op 316 2 surface surface NN cord-019051-gtruu1op 316 3 structure structure NN cord-019051-gtruu1op 316 4 reveals reveal VBZ cord-019051-gtruu1op 316 5 a a DT cord-019051-gtruu1op 316 6 regular regular JJ cord-019051-gtruu1op 316 7 pattern pattern NN cord-019051-gtruu1op 316 8 with with IN cord-019051-gtruu1op 316 9 distinctive distinctive JJ cord-019051-gtruu1op 316 10 features feature NNS cord-019051-gtruu1op 316 11 . . . cord-019051-gtruu1op 317 1 Surface surface NN cord-019051-gtruu1op 317 2 projections projection NNS cord-019051-gtruu1op 317 3 are be VBP cord-019051-gtruu1op 317 4 often often RB cord-019051-gtruu1op 317 5 lost lose VBN cord-019051-gtruu1op 317 6 during during IN cord-019051-gtruu1op 317 7 preparation preparation NN cord-019051-gtruu1op 317 8 . . . cord-019051-gtruu1op 318 1 Distinct distinct JJ cord-019051-gtruu1op 318 2 filaments filament NNS cord-019051-gtruu1op 318 3 protrude protrude VBP cord-019051-gtruu1op 318 4 from from IN cord-019051-gtruu1op 318 5 the the DT cord-019051-gtruu1op 318 6 12 12 CD cord-019051-gtruu1op 318 7 vertices/ vertices/ CD cord-019051-gtruu1op 318 8 pentons penton NNS cord-019051-gtruu1op 318 9 [ [ -LRB- cord-019051-gtruu1op 318 10 112 112 CD cord-019051-gtruu1op 318 11 ] ] -RRB- cord-019051-gtruu1op 318 12 [ [ -LRB- cord-019051-gtruu1op 318 13 113 113 CD cord-019051-gtruu1op 318 14 ] ] -RRB- cord-019051-gtruu1op 318 15 [ [ -LRB- cord-019051-gtruu1op 318 16 114 114 CD cord-019051-gtruu1op 318 17 ] ] -RRB- cord-019051-gtruu1op 318 18 . . . cord-019051-gtruu1op 319 1 The the DT cord-019051-gtruu1op 319 2 genome genome NN cord-019051-gtruu1op 319 3 is be VBZ cord-019051-gtruu1op 319 4 not not RB cord-019051-gtruu1op 319 5 segmented segment VBN cord-019051-gtruu1op 319 6 and and CC cord-019051-gtruu1op 319 7 contains contain VBZ cord-019051-gtruu1op 319 8 a a DT cord-019051-gtruu1op 319 9 single single JJ cord-019051-gtruu1op 319 10 molecule molecule NN cord-019051-gtruu1op 319 11 of of IN cord-019051-gtruu1op 319 12 linear linear JJ cord-019051-gtruu1op 319 13 double double RB cord-019051-gtruu1op 319 14 - - HYPH cord-019051-gtruu1op 319 15 stranded strand VBN cord-019051-gtruu1op 319 16 DNA dna NN cord-019051-gtruu1op 319 17 with with IN cord-019051-gtruu1op 319 18 terminally terminally RB cord-019051-gtruu1op 319 19 redundant redundant JJ cord-019051-gtruu1op 319 20 sequences sequence NNS cord-019051-gtruu1op 319 21 , , , cord-019051-gtruu1op 319 22 which which WDT cord-019051-gtruu1op 319 23 have have VBP cord-019051-gtruu1op 319 24 inverted invert VBN cord-019051-gtruu1op 319 25 terminal terminal JJ cord-019051-gtruu1op 319 26 repetitions repetition NNS cord-019051-gtruu1op 319 27 ( ( -LRB- cord-019051-gtruu1op 319 28 ITR ITR NNP cord-019051-gtruu1op 319 29 ) ) -RRB- cord-019051-gtruu1op 319 30 . . . cord-019051-gtruu1op 320 1 The the DT cord-019051-gtruu1op 320 2 complete complete JJ cord-019051-gtruu1op 320 3 genome genome NN cord-019051-gtruu1op 320 4 of of IN cord-019051-gtruu1op 320 5 mastadenoviruses mastadenoviruse NNS cord-019051-gtruu1op 320 6 is be VBZ cord-019051-gtruu1op 320 7 approximately approximately RB cord-019051-gtruu1op 320 8 31 31 CD cord-019051-gtruu1op 320 9 - - SYM cord-019051-gtruu1op 320 10 36 36 CD cord-019051-gtruu1op 320 11 kpb kpb NN cord-019051-gtruu1op 320 12 long long RB cord-019051-gtruu1op 320 13 and and CC cord-019051-gtruu1op 320 14 has have VBZ cord-019051-gtruu1op 320 15 a a DT cord-019051-gtruu1op 320 16 guanine guanine NN cord-019051-gtruu1op 320 17 + + CC cord-019051-gtruu1op 320 18 cytosine cytosine NN cord-019051-gtruu1op 320 19 content content NN cord-019051-gtruu1op 320 20 of of IN cord-019051-gtruu1op 320 21 48 48 CD cord-019051-gtruu1op 320 22 - - SYM cord-019051-gtruu1op 320 23 61 61 CD cord-019051-gtruu1op 320 24 % % NN cord-019051-gtruu1op 320 25 . . . cord-019051-gtruu1op 321 1 The the DT cord-019051-gtruu1op 321 2 genome genome NN cord-019051-gtruu1op 321 3 has have VBZ cord-019051-gtruu1op 321 4 a a DT cord-019051-gtruu1op 321 5 terminal terminal JJ cord-019051-gtruu1op 321 6 protein protein NN cord-019051-gtruu1op 321 7 , , , cord-019051-gtruu1op 321 8 which which WDT cord-019051-gtruu1op 321 9 is be VBZ cord-019051-gtruu1op 321 10 covalently covalently RB cord-019051-gtruu1op 321 11 linked link VBN cord-019051-gtruu1op 321 12 to to IN cord-019051-gtruu1op 321 13 the the DT cord-019051-gtruu1op 321 14 5'-end 5'-end CD cord-019051-gtruu1op 321 15 of of IN cord-019051-gtruu1op 321 16 each each DT cord-019051-gtruu1op 321 17 DNA dna NN cord-019051-gtruu1op 321 18 strand strand NN cord-019051-gtruu1op 321 19 [ [ -LRB- cord-019051-gtruu1op 321 20 114 114 CD cord-019051-gtruu1op 321 21 , , , cord-019051-gtruu1op 321 22 115 115 CD cord-019051-gtruu1op 321 23 ] ] -RRB- cord-019051-gtruu1op 321 24 . . . cord-019051-gtruu1op 322 1 The the DT cord-019051-gtruu1op 322 2 viral viral JJ cord-019051-gtruu1op 322 3 genome genome NN cord-019051-gtruu1op 322 4 encodes encode VBZ cord-019051-gtruu1op 322 5 structural structural JJ cord-019051-gtruu1op 322 6 proteins protein NNS cord-019051-gtruu1op 322 7 and and CC cord-019051-gtruu1op 322 8 non non JJ cord-019051-gtruu1op 322 9 - - JJ cord-019051-gtruu1op 322 10 structural structural JJ cord-019051-gtruu1op 322 11 proteins protein NNS cord-019051-gtruu1op 322 12 . . . cord-019051-gtruu1op 323 1 Virions virion NNS cord-019051-gtruu1op 323 2 consist consist VBP cord-019051-gtruu1op 323 3 of of IN cord-019051-gtruu1op 323 4 11 11 CD cord-019051-gtruu1op 323 5 proteins protein NNS cord-019051-gtruu1op 323 6 located locate VBN cord-019051-gtruu1op 323 7 in in IN cord-019051-gtruu1op 323 8 the the DT cord-019051-gtruu1op 323 9 capsid capsid NN cord-019051-gtruu1op 323 10 , , , cord-019051-gtruu1op 323 11 fibers fiber NNS cord-019051-gtruu1op 323 12 , , , cord-019051-gtruu1op 323 13 and and CC cord-019051-gtruu1op 323 14 core core NN cord-019051-gtruu1op 323 15 . . . cord-019051-gtruu1op 324 1 The the DT cord-019051-gtruu1op 324 2 capsid capsid NN cord-019051-gtruu1op 324 3 is be VBZ cord-019051-gtruu1op 324 4 comprised comprise VBN cord-019051-gtruu1op 324 5 of of IN cord-019051-gtruu1op 324 6 seven seven CD cord-019051-gtruu1op 324 7 polypeptides polypeptide NNS cord-019051-gtruu1op 324 8 , , , cord-019051-gtruu1op 324 9 polypeptide polypeptide NN cord-019051-gtruu1op 324 10 II II NNP cord-019051-gtruu1op 324 11 which which WDT cord-019051-gtruu1op 324 12 is be VBZ cord-019051-gtruu1op 324 13 the the DT cord-019051-gtruu1op 324 14 basis basis NN cord-019051-gtruu1op 324 15 for for IN cord-019051-gtruu1op 324 16 the the DT cord-019051-gtruu1op 324 17 hexon hexon NN cord-019051-gtruu1op 324 18 ( ( -LRB- cord-019051-gtruu1op 324 19 three three CD cord-019051-gtruu1op 324 20 tightly tightly RB cord-019051-gtruu1op 324 21 associated associate VBN cord-019051-gtruu1op 324 22 proteins protein NNS cord-019051-gtruu1op 324 23 ) ) -RRB- cord-019051-gtruu1op 324 24 . . . cord-019051-gtruu1op 325 1 Polypeptides polypeptide NNS cord-019051-gtruu1op 325 2 VI VI NNP cord-019051-gtruu1op 325 3 , , , cord-019051-gtruu1op 325 4 VIII VIII NNP cord-019051-gtruu1op 325 5 , , , cord-019051-gtruu1op 325 6 IX IX NNP cord-019051-gtruu1op 325 7 are be VBP cord-019051-gtruu1op 325 8 associated associate VBN cord-019051-gtruu1op 325 9 with with IN cord-019051-gtruu1op 325 10 the the DT cord-019051-gtruu1op 325 11 hexon hexon NN cord-019051-gtruu1op 325 12 , , , cord-019051-gtruu1op 325 13 polypeptides polypeptide NNS cord-019051-gtruu1op 325 14 VI VI NNP cord-019051-gtruu1op 325 15 and and CC cord-019051-gtruu1op 325 16 VIII VIII NNP cord-019051-gtruu1op 325 17 serve serve VBP cord-019051-gtruu1op 325 18 as as IN cord-019051-gtruu1op 325 19 bridge bridge NN cord-019051-gtruu1op 325 20 between between IN cord-019051-gtruu1op 325 21 the the DT cord-019051-gtruu1op 325 22 capsid capsid NN cord-019051-gtruu1op 325 23 and and CC cord-019051-gtruu1op 325 24 the the DT cord-019051-gtruu1op 325 25 core core NN cord-019051-gtruu1op 325 26 . . . cord-019051-gtruu1op 326 1 Five five CD cord-019051-gtruu1op 326 2 polypeptide polypeptide NN cord-019051-gtruu1op 326 3 III iii CD cord-019051-gtruu1op 326 4 copies copy NNS cord-019051-gtruu1op 326 5 are be VBP cord-019051-gtruu1op 326 6 the the DT cord-019051-gtruu1op 326 7 basis basis NN cord-019051-gtruu1op 326 8 for for IN cord-019051-gtruu1op 326 9 the the DT cord-019051-gtruu1op 326 10 penton penton NNP cord-019051-gtruu1op 326 11 . . . cord-019051-gtruu1op 327 1 Polypeptide Polypeptide NNP cord-019051-gtruu1op 327 2 IV IV NNP cord-019051-gtruu1op 327 3 forms form VBZ cord-019051-gtruu1op 327 4 the the DT cord-019051-gtruu1op 327 5 trimeric trimeric JJ cord-019051-gtruu1op 327 6 fiber fiber NN cord-019051-gtruu1op 327 7 [ [ -LRB- cord-019051-gtruu1op 327 8 116 116 CD cord-019051-gtruu1op 327 9 ] ] -RRB- cord-019051-gtruu1op 327 10 , , , cord-019051-gtruu1op 327 11 which which WDT cord-019051-gtruu1op 327 12 has have VBZ cord-019051-gtruu1op 327 13 a a DT cord-019051-gtruu1op 327 14 knob knob NN cord-019051-gtruu1op 327 15 domain domain NN cord-019051-gtruu1op 327 16 that that WDT cord-019051-gtruu1op 327 17 serves serve VBZ cord-019051-gtruu1op 327 18 as as IN cord-019051-gtruu1op 327 19 a a DT cord-019051-gtruu1op 327 20 viral viral JJ cord-019051-gtruu1op 327 21 receptor receptor NN cord-019051-gtruu1op 327 22 for for IN cord-019051-gtruu1op 327 23 the the DT cord-019051-gtruu1op 327 24 target target NN cord-019051-gtruu1op 327 25 host host NN cord-019051-gtruu1op 327 26 cell cell NN cord-019051-gtruu1op 327 27 . . . cord-019051-gtruu1op 328 1 The the DT cord-019051-gtruu1op 328 2 cell cell NN cord-019051-gtruu1op 328 3 receptor receptor NN cord-019051-gtruu1op 328 4 is be VBZ cord-019051-gtruu1op 328 5 the the DT cord-019051-gtruu1op 328 6 receptor receptor NN cord-019051-gtruu1op 328 7 for for IN cord-019051-gtruu1op 328 8 coxsackie coxsackie NNP cord-019051-gtruu1op 328 9 B B NNP cord-019051-gtruu1op 328 10 virus virus NN cord-019051-gtruu1op 328 11 and and CC cord-019051-gtruu1op 328 12 adenovirus adenovirus NN cord-019051-gtruu1op 328 13 ( ( -LRB- cord-019051-gtruu1op 328 14 CAR car NN cord-019051-gtruu1op 328 15 ) ) -RRB- cord-019051-gtruu1op 328 16 for for IN cord-019051-gtruu1op 328 17 adenoviruses adenovirus NNS cord-019051-gtruu1op 328 18 A A NNP cord-019051-gtruu1op 328 19 , , , cord-019051-gtruu1op 328 20 C C NNP cord-019051-gtruu1op 328 21 , , , cord-019051-gtruu1op 328 22 D D NNP cord-019051-gtruu1op 328 23 , , , cord-019051-gtruu1op 328 24 E E NNP cord-019051-gtruu1op 328 25 and and CC cord-019051-gtruu1op 328 26 F F NNP cord-019051-gtruu1op 328 27 and and CC cord-019051-gtruu1op 328 28 CD46 CD46 NNP cord-019051-gtruu1op 328 29 for for IN cord-019051-gtruu1op 328 30 adenoviruses adenovirus NNS cord-019051-gtruu1op 328 31 B b NN cord-019051-gtruu1op 328 32 with with IN cord-019051-gtruu1op 328 33 the the DT cord-019051-gtruu1op 328 34 exception exception NN cord-019051-gtruu1op 328 35 of of IN cord-019051-gtruu1op 328 36 serotypes serotype NNS cord-019051-gtruu1op 328 37 3 3 CD cord-019051-gtruu1op 328 38 and and CC cord-019051-gtruu1op 328 39 7 7 CD cord-019051-gtruu1op 328 40 [ [ -LRB- cord-019051-gtruu1op 328 41 117 117 CD cord-019051-gtruu1op 328 42 ] ] -RRB- cord-019051-gtruu1op 328 43 . . . cord-019051-gtruu1op 329 1 The the DT cord-019051-gtruu1op 329 2 core core NN cord-019051-gtruu1op 329 3 consists consist VBZ cord-019051-gtruu1op 329 4 of of IN cord-019051-gtruu1op 329 5 four four CD cord-019051-gtruu1op 329 6 proteins protein NNS cord-019051-gtruu1op 329 7 ( ( -LRB- cord-019051-gtruu1op 329 8 V v NN cord-019051-gtruu1op 329 9 , , , cord-019051-gtruu1op 329 10 VII VII NNP cord-019051-gtruu1op 329 11 , , , cord-019051-gtruu1op 329 12 mu mu NNS cord-019051-gtruu1op 329 13 and and CC cord-019051-gtruu1op 329 14 the the DT cord-019051-gtruu1op 329 15 terminal terminal JJ cord-019051-gtruu1op 329 16 protein protein NN cord-019051-gtruu1op 329 17 , , , cord-019051-gtruu1op 329 18 which which WDT cord-019051-gtruu1op 329 19 is be VBZ cord-019051-gtruu1op 329 20 covalently covalently RB cord-019051-gtruu1op 329 21 linked link VBN cord-019051-gtruu1op 329 22 to to IN cord-019051-gtruu1op 329 23 the the DT cord-019051-gtruu1op 329 24 5 5 CD cord-019051-gtruu1op 329 25 ´ ´ CD cord-019051-gtruu1op 329 26 end end NN cord-019051-gtruu1op 329 27 of of IN cord-019051-gtruu1op 329 28 the the DT cord-019051-gtruu1op 329 29 DNA dna NN cord-019051-gtruu1op 329 30 ) ) -RRB- cord-019051-gtruu1op 329 31 and and CC cord-019051-gtruu1op 329 32 the the DT cord-019051-gtruu1op 329 33 DNA dna NN cord-019051-gtruu1op 329 34 ( ( -LRB- cord-019051-gtruu1op 329 35 reviewed review VBN cord-019051-gtruu1op 329 36 in in IN cord-019051-gtruu1op 329 37 [ [ -LRB- cord-019051-gtruu1op 329 38 112 112 CD cord-019051-gtruu1op 329 39 ] ] -RRB- cord-019051-gtruu1op 329 40 ) ) -RRB- cord-019051-gtruu1op 329 41 . . . cord-019051-gtruu1op 330 1 The the DT cord-019051-gtruu1op 330 2 replication replication NN cord-019051-gtruu1op 330 3 cycle cycle NN cord-019051-gtruu1op 330 4 of of IN cord-019051-gtruu1op 330 5 adenoviruses adenovirus NNS cord-019051-gtruu1op 330 6 is be VBZ cord-019051-gtruu1op 330 7 divided divide VBN cord-019051-gtruu1op 330 8 into into IN cord-019051-gtruu1op 330 9 two two CD cord-019051-gtruu1op 330 10 phases phase NNS cord-019051-gtruu1op 330 11 . . . cord-019051-gtruu1op 331 1 The the DT cord-019051-gtruu1op 331 2 early early JJ cord-019051-gtruu1op 331 3 phase phase NN cord-019051-gtruu1op 331 4 includes include VBZ cord-019051-gtruu1op 331 5 adsorption adsorption NN cord-019051-gtruu1op 331 6 of of IN cord-019051-gtruu1op 331 7 the the DT cord-019051-gtruu1op 331 8 virus virus NN cord-019051-gtruu1op 331 9 to to IN cord-019051-gtruu1op 331 10 the the DT cord-019051-gtruu1op 331 11 host host NN cord-019051-gtruu1op 331 12 cell cell NN cord-019051-gtruu1op 331 13 , , , cord-019051-gtruu1op 331 14 penetration penetration NN cord-019051-gtruu1op 331 15 , , , cord-019051-gtruu1op 331 16 transcription transcription NN cord-019051-gtruu1op 331 17 and and CC cord-019051-gtruu1op 331 18 translation translation NN cord-019051-gtruu1op 331 19 of of IN cord-019051-gtruu1op 331 20 early early JJ cord-019051-gtruu1op 331 21 genes gene NNS cord-019051-gtruu1op 331 22 . . . cord-019051-gtruu1op 332 1 The the DT cord-019051-gtruu1op 332 2 early early JJ cord-019051-gtruu1op 332 3 gene gene NN cord-019051-gtruu1op 332 4 products product NNS cord-019051-gtruu1op 332 5 mediate mediate VBP cord-019051-gtruu1op 332 6 gene gene NN cord-019051-gtruu1op 332 7 expression expression NN cord-019051-gtruu1op 332 8 and and CC cord-019051-gtruu1op 332 9 DNA dna NN cord-019051-gtruu1op 332 10 replication replication NN cord-019051-gtruu1op 332 11 , , , cord-019051-gtruu1op 332 12 block block NN cord-019051-gtruu1op 332 13 apoptosis apoptosis NN cord-019051-gtruu1op 332 14 and and CC cord-019051-gtruu1op 332 15 promote promote VB cord-019051-gtruu1op 332 16 the the DT cord-019051-gtruu1op 332 17 cell cell NN cord-019051-gtruu1op 332 18 cycle cycle NN cord-019051-gtruu1op 332 19 progression progression NN cord-019051-gtruu1op 332 20 . . . cord-019051-gtruu1op 333 1 In in IN cord-019051-gtruu1op 333 2 addition addition NN cord-019051-gtruu1op 333 3 , , , cord-019051-gtruu1op 333 4 they -PRON- PRP cord-019051-gtruu1op 333 5 possess possess VBP cord-019051-gtruu1op 333 6 potent potent JJ cord-019051-gtruu1op 333 7 immunomodulatory immunomodulatory JJ cord-019051-gtruu1op 333 8 functions function NNS cord-019051-gtruu1op 333 9 ( ( -LRB- cord-019051-gtruu1op 333 10 reviewed review VBN cord-019051-gtruu1op 333 11 in in IN cord-019051-gtruu1op 333 12 [ [ -LRB- cord-019051-gtruu1op 333 13 112 112 CD cord-019051-gtruu1op 333 14 ] ] -RRB- cord-019051-gtruu1op 333 15 ) ) -RRB- cord-019051-gtruu1op 333 16 . . . cord-019051-gtruu1op 334 1 The the DT cord-019051-gtruu1op 334 2 viral viral JJ cord-019051-gtruu1op 334 3 E1A e1a NN cord-019051-gtruu1op 334 4 gene gene NN cord-019051-gtruu1op 334 5 product product NN cord-019051-gtruu1op 334 6 should should MD cord-019051-gtruu1op 334 7 briefly briefly RB cord-019051-gtruu1op 334 8 be be VB cord-019051-gtruu1op 334 9 mentioned mention VBN cord-019051-gtruu1op 334 10 : : : cord-019051-gtruu1op 334 11 In in IN cord-019051-gtruu1op 334 12 the the DT cord-019051-gtruu1op 334 13 nucleus nucleus NN cord-019051-gtruu1op 334 14 , , , cord-019051-gtruu1op 334 15 E1A E1A NNP cord-019051-gtruu1op 334 16 activates activate VBZ cord-019051-gtruu1op 334 17 the the DT cord-019051-gtruu1op 334 18 expression expression NN cord-019051-gtruu1op 334 19 of of IN cord-019051-gtruu1op 334 20 a a DT cord-019051-gtruu1op 334 21 number number NN cord-019051-gtruu1op 334 22 of of IN cord-019051-gtruu1op 334 23 genes gene NNS cord-019051-gtruu1op 334 24 by by IN cord-019051-gtruu1op 334 25 interacting interact VBG cord-019051-gtruu1op 334 26 with with IN cord-019051-gtruu1op 334 27 cellular cellular JJ cord-019051-gtruu1op 334 28 transcription transcription NN cord-019051-gtruu1op 334 29 factors factor NNS cord-019051-gtruu1op 334 30 and and CC cord-019051-gtruu1op 334 31 other other JJ cord-019051-gtruu1op 334 32 cellular cellular JJ cord-019051-gtruu1op 334 33 regulatory regulatory JJ cord-019051-gtruu1op 334 34 proteins protein NNS cord-019051-gtruu1op 334 35 [ [ -LRB- cord-019051-gtruu1op 334 36 112 112 CD cord-019051-gtruu1op 334 37 ] ] -RRB- cord-019051-gtruu1op 334 38 . . . cord-019051-gtruu1op 335 1 E1A E1A NNP cord-019051-gtruu1op 335 2 has have VBZ cord-019051-gtruu1op 335 3 been be VBN cord-019051-gtruu1op 335 4 postulated postulate VBN cord-019051-gtruu1op 335 5 to to TO cord-019051-gtruu1op 335 6 play play VB cord-019051-gtruu1op 335 7 role role NN cord-019051-gtruu1op 335 8 in in IN cord-019051-gtruu1op 335 9 the the DT cord-019051-gtruu1op 335 10 pathogenesis pathogenesis NN cord-019051-gtruu1op 335 11 of of IN cord-019051-gtruu1op 335 12 chronic chronic JJ cord-019051-gtruu1op 335 13 obstructive obstructive JJ cord-019051-gtruu1op 335 14 pulmonary pulmonary JJ cord-019051-gtruu1op 335 15 disease disease NN cord-019051-gtruu1op 335 16 ( ( -LRB- cord-019051-gtruu1op 335 17 COPD COPD NNP cord-019051-gtruu1op 335 18 ) ) -RRB- cord-019051-gtruu1op 336 1 [ [ -LRB- cord-019051-gtruu1op 336 2 118 118 CD cord-019051-gtruu1op 336 3 ] ] -RRB- cord-019051-gtruu1op 337 1 [ [ -LRB- cord-019051-gtruu1op 337 2 119 119 CD cord-019051-gtruu1op 337 3 ] ] -RRB- cord-019051-gtruu1op 337 4 [ [ -LRB- cord-019051-gtruu1op 337 5 120 120 CD cord-019051-gtruu1op 337 6 ] ] -RRB- cord-019051-gtruu1op 337 7 . . . cord-019051-gtruu1op 338 1 Human human JJ cord-019051-gtruu1op 338 2 adenovirus adenovirus NN cord-019051-gtruu1op 338 3 A A NNP cord-019051-gtruu1op 338 4 - - HYPH cord-019051-gtruu1op 338 5 F F NNP cord-019051-gtruu1op 338 6 can can MD cord-019051-gtruu1op 338 7 cause cause VB cord-019051-gtruu1op 338 8 human human JJ cord-019051-gtruu1op 338 9 infections infection NNS cord-019051-gtruu1op 338 10 ranging range VBG cord-019051-gtruu1op 338 11 from from IN cord-019051-gtruu1op 338 12 respiratory respiratory JJ cord-019051-gtruu1op 338 13 disease disease NN cord-019051-gtruu1op 338 14 , , , cord-019051-gtruu1op 338 15 and and CC cord-019051-gtruu1op 338 16 conjunctivitis conjunctivitis NN cord-019051-gtruu1op 338 17 ( ( -LRB- cord-019051-gtruu1op 338 18 B b NN cord-019051-gtruu1op 338 19 and and CC cord-019051-gtruu1op 338 20 D D NNP cord-019051-gtruu1op 338 21 ) ) -RRB- cord-019051-gtruu1op 338 22 , , , cord-019051-gtruu1op 338 23 to to IN cord-019051-gtruu1op 338 24 gastroenteritis gastroenteritis NN cord-019051-gtruu1op 338 25 ( ( -LRB- cord-019051-gtruu1op 338 26 F F NNP cord-019051-gtruu1op 338 27 serotypes serotype NNS cord-019051-gtruu1op 338 28 40 40 CD cord-019051-gtruu1op 338 29 and and CC cord-019051-gtruu1op 338 30 41 41 CD cord-019051-gtruu1op 338 31 ) ) -RRB- cord-019051-gtruu1op 338 32 [ [ -LRB- cord-019051-gtruu1op 338 33 106 106 CD cord-019051-gtruu1op 338 34 , , , cord-019051-gtruu1op 338 35 112 112 CD cord-019051-gtruu1op 338 36 ] ] -RRB- cord-019051-gtruu1op 338 37 . . . cord-019051-gtruu1op 339 1 The the DT cord-019051-gtruu1op 339 2 most most RBS cord-019051-gtruu1op 339 3 common common JJ cord-019051-gtruu1op 339 4 clinical clinical JJ cord-019051-gtruu1op 339 5 picture picture NN cord-019051-gtruu1op 339 6 after after IN cord-019051-gtruu1op 339 7 adenovirus adenovirus NN cord-019051-gtruu1op 339 8 infection infection NN cord-019051-gtruu1op 339 9 of of IN cord-019051-gtruu1op 339 10 the the DT cord-019051-gtruu1op 339 11 respiratory respiratory JJ cord-019051-gtruu1op 339 12 tract tract NN cord-019051-gtruu1op 339 13 is be VBZ cord-019051-gtruu1op 339 14 mild mild JJ cord-019051-gtruu1op 339 15 self self NN cord-019051-gtruu1op 339 16 - - HYPH cord-019051-gtruu1op 339 17 limiting limit VBG cord-019051-gtruu1op 339 18 upper upper JJ cord-019051-gtruu1op 339 19 respiratory respiratory JJ cord-019051-gtruu1op 339 20 disease disease NN cord-019051-gtruu1op 339 21 with with IN cord-019051-gtruu1op 339 22 nasal nasal NN cord-019051-gtruu1op 339 23 congestion congestion NN cord-019051-gtruu1op 339 24 , , , cord-019051-gtruu1op 339 25 coryza coryza NNP cord-019051-gtruu1op 339 26 and and CC cord-019051-gtruu1op 339 27 cough cough NN cord-019051-gtruu1op 339 28 [ [ -LRB- cord-019051-gtruu1op 339 29 106 106 CD cord-019051-gtruu1op 339 30 , , , cord-019051-gtruu1op 339 31 113 113 CD cord-019051-gtruu1op 339 32 ] ] -RRB- cord-019051-gtruu1op 339 33 . . . cord-019051-gtruu1op 340 1 Some some DT cord-019051-gtruu1op 340 2 patients patient NNS cord-019051-gtruu1op 340 3 develop develop VBP cord-019051-gtruu1op 340 4 exsudative exsudative JJ cord-019051-gtruu1op 340 5 tonsillitis tonsillitis NN cord-019051-gtruu1op 340 6 that that WDT cord-019051-gtruu1op 340 7 is be VBZ cord-019051-gtruu1op 340 8 clinically clinically RB cord-019051-gtruu1op 340 9 indistinguishable indistinguishable JJ cord-019051-gtruu1op 340 10 from from IN cord-019051-gtruu1op 340 11 streptococcus streptococcus NN cord-019051-gtruu1op 340 12 tonsillitis tonsillitis NN cord-019051-gtruu1op 340 13 [ [ -LRB- cord-019051-gtruu1op 340 14 120 120 CD cord-019051-gtruu1op 340 15 ] ] -RRB- cord-019051-gtruu1op 340 16 . . . cord-019051-gtruu1op 341 1 These these DT cord-019051-gtruu1op 341 2 infections infection NNS cord-019051-gtruu1op 341 3 are be VBP cord-019051-gtruu1op 341 4 commonly commonly RB cord-019051-gtruu1op 341 5 caused cause VBN cord-019051-gtruu1op 341 6 by by IN cord-019051-gtruu1op 341 7 serotype serotype NN cord-019051-gtruu1op 341 8 1 1 CD cord-019051-gtruu1op 341 9 , , , cord-019051-gtruu1op 341 10 2 2 CD cord-019051-gtruu1op 341 11 , , , cord-019051-gtruu1op 341 12 5 5 CD cord-019051-gtruu1op 341 13 and and CC cord-019051-gtruu1op 341 14 6 6 CD cord-019051-gtruu1op 341 15 C c NN cord-019051-gtruu1op 341 16 adenoviruses adenovirus NNS cord-019051-gtruu1op 341 17 and and CC cord-019051-gtruu1op 341 18 serotype serotype NN cord-019051-gtruu1op 341 19 3 3 CD cord-019051-gtruu1op 341 20 B b NN cord-019051-gtruu1op 341 21 adenovirus adenovirus NN cord-019051-gtruu1op 341 22 [ [ -LRB- cord-019051-gtruu1op 341 23 107 107 CD cord-019051-gtruu1op 341 24 , , , cord-019051-gtruu1op 341 25 109 109 CD cord-019051-gtruu1op 341 26 ] ] -RRB- cord-019051-gtruu1op 341 27 . . . cord-019051-gtruu1op 342 1 Respiratory respiratory JJ cord-019051-gtruu1op 342 2 symptoms symptom NNS cord-019051-gtruu1op 342 3 may may MD cord-019051-gtruu1op 342 4 be be VB cord-019051-gtruu1op 342 5 accompanied accompany VBN cord-019051-gtruu1op 342 6 by by IN cord-019051-gtruu1op 342 7 systemic systemic JJ cord-019051-gtruu1op 342 8 manifestations manifestation NNS cord-019051-gtruu1op 342 9 including include VBG cord-019051-gtruu1op 342 10 generalized generalize VBN cord-019051-gtruu1op 342 11 malaise malaise NN cord-019051-gtruu1op 342 12 , , , cord-019051-gtruu1op 342 13 chills chill NNS cord-019051-gtruu1op 342 14 , , , cord-019051-gtruu1op 342 15 fever fever NN cord-019051-gtruu1op 342 16 and and CC cord-019051-gtruu1op 342 17 headache headache NN cord-019051-gtruu1op 342 18 [ [ -LRB- cord-019051-gtruu1op 342 19 106 106 CD cord-019051-gtruu1op 342 20 ] ] -RRB- cord-019051-gtruu1op 342 21 . . . cord-019051-gtruu1op 343 1 However however RB cord-019051-gtruu1op 343 2 , , , cord-019051-gtruu1op 343 3 adenoviruses adenovirus NNS cord-019051-gtruu1op 343 4 may may MD cord-019051-gtruu1op 343 5 infect infect VB cord-019051-gtruu1op 343 6 alveolar alveolar JJ cord-019051-gtruu1op 343 7 and and CC cord-019051-gtruu1op 343 8 bronchiolar bronchiolar JJ cord-019051-gtruu1op 343 9 epithelial epithelial JJ cord-019051-gtruu1op 343 10 cells cell NNS cord-019051-gtruu1op 343 11 [ [ -LRB- cord-019051-gtruu1op 343 12 121 121 CD cord-019051-gtruu1op 343 13 ] ] -RRB- cord-019051-gtruu1op 343 14 and and CC cord-019051-gtruu1op 343 15 cause cause VB cord-019051-gtruu1op 343 16 pneumonia pneumonia NN cord-019051-gtruu1op 343 17 , , , cord-019051-gtruu1op 343 18 bronchiolitis bronchiolitis NN cord-019051-gtruu1op 343 19 or or CC cord-019051-gtruu1op 343 20 bronchiolitis bronchiolitis NNP cord-019051-gtruu1op 343 21 obliterans obliterans NNPS cord-019051-gtruu1op 343 22 [ [ -LRB- cord-019051-gtruu1op 343 23 122 122 CD cord-019051-gtruu1op 343 24 ] ] -RRB- cord-019051-gtruu1op 343 25 [ [ -LRB- cord-019051-gtruu1op 343 26 123 123 CD cord-019051-gtruu1op 343 27 ] ] -RRB- cord-019051-gtruu1op 343 28 [ [ -LRB- cord-019051-gtruu1op 343 29 124 124 CD cord-019051-gtruu1op 343 30 ] ] -RRB- cord-019051-gtruu1op 343 31 . . . cord-019051-gtruu1op 344 1 Adenoviruses adenovirus NNS cord-019051-gtruu1op 344 2 account account VBP cord-019051-gtruu1op 344 3 for for IN cord-019051-gtruu1op 344 4 approximately approximately RB cord-019051-gtruu1op 344 5 10 10 CD cord-019051-gtruu1op 344 6 % % NN cord-019051-gtruu1op 344 7 of of IN cord-019051-gtruu1op 344 8 pneumonias pneumonia NNS cord-019051-gtruu1op 344 9 in in IN cord-019051-gtruu1op 344 10 children child NNS cord-019051-gtruu1op 344 11 [ [ -LRB- cord-019051-gtruu1op 344 12 106 106 CD cord-019051-gtruu1op 344 13 ] ] -RRB- cord-019051-gtruu1op 344 14 . . . cord-019051-gtruu1op 345 1 In in IN cord-019051-gtruu1op 345 2 contrast contrast NN cord-019051-gtruu1op 345 3 to to IN cord-019051-gtruu1op 345 4 many many JJ cord-019051-gtruu1op 345 5 other other JJ cord-019051-gtruu1op 345 6 respiratory respiratory JJ cord-019051-gtruu1op 345 7 viruses virus NNS cord-019051-gtruu1op 345 8 , , , cord-019051-gtruu1op 345 9 both both CC cord-019051-gtruu1op 345 10 persistent persistent JJ cord-019051-gtruu1op 345 11 and and CC cord-019051-gtruu1op 345 12 latent latent JJ cord-019051-gtruu1op 345 13 infections infection NNS cord-019051-gtruu1op 345 14 have have VBP cord-019051-gtruu1op 345 15 been be VBN cord-019051-gtruu1op 345 16 described describe VBN cord-019051-gtruu1op 345 17 , , , cord-019051-gtruu1op 345 18 particularly particularly RB cord-019051-gtruu1op 345 19 in in IN cord-019051-gtruu1op 345 20 lymphocytes lymphocyte NNS cord-019051-gtruu1op 345 21 [ [ -LRB- cord-019051-gtruu1op 345 22 106 106 CD cord-019051-gtruu1op 345 23 ] ] -RRB- cord-019051-gtruu1op 345 24 . . . cord-019051-gtruu1op 346 1 Adenoviral Adenoviral NNP cord-019051-gtruu1op 346 2 DNA DNA NNP cord-019051-gtruu1op 346 3 may may MD cord-019051-gtruu1op 346 4 persist persist VB cord-019051-gtruu1op 346 5 in in IN cord-019051-gtruu1op 346 6 the the DT cord-019051-gtruu1op 346 7 nuclei nucleus NNS cord-019051-gtruu1op 346 8 of of IN cord-019051-gtruu1op 346 9 infected infected JJ cord-019051-gtruu1op 346 10 cells cell NNS cord-019051-gtruu1op 346 11 or or CC cord-019051-gtruu1op 346 12 even even RB cord-019051-gtruu1op 346 13 integrate integrate VB cord-019051-gtruu1op 346 14 into into IN cord-019051-gtruu1op 346 15 the the DT cord-019051-gtruu1op 346 16 host host NN cord-019051-gtruu1op 346 17 DNA dna NN cord-019051-gtruu1op 346 18 . . . cord-019051-gtruu1op 347 1 Adenoviral Adenoviral NNP cord-019051-gtruu1op 347 2 E1A e1a NN cord-019051-gtruu1op 347 3 protein protein NN cord-019051-gtruu1op 347 4 has have VBZ cord-019051-gtruu1op 347 5 been be VBN cord-019051-gtruu1op 347 6 postulated postulate VBN cord-019051-gtruu1op 347 7 to to TO cord-019051-gtruu1op 347 8 play play VB cord-019051-gtruu1op 347 9 a a DT cord-019051-gtruu1op 347 10 role role NN cord-019051-gtruu1op 347 11 in in IN cord-019051-gtruu1op 347 12 the the DT cord-019051-gtruu1op 347 13 pathogenesis pathogenesis NN cord-019051-gtruu1op 347 14 of of IN cord-019051-gtruu1op 347 15 COPD COPD NNP cord-019051-gtruu1op 347 16 [ [ -LRB- cord-019051-gtruu1op 347 17 121 121 CD cord-019051-gtruu1op 347 18 ] ] -RRB- cord-019051-gtruu1op 347 19 . . . cord-019051-gtruu1op 348 1 Adenoviral Adenoviral NNP cord-019051-gtruu1op 348 2 DNA DNA NNP cord-019051-gtruu1op 348 3 was be VBD cord-019051-gtruu1op 348 4 found find VBN cord-019051-gtruu1op 348 5 in in IN cord-019051-gtruu1op 348 6 the the DT cord-019051-gtruu1op 348 7 lungs lung NNS cord-019051-gtruu1op 348 8 of of IN cord-019051-gtruu1op 348 9 COPD COPD NNP cord-019051-gtruu1op 348 10 patients patient NNS cord-019051-gtruu1op 348 11 and and CC cord-019051-gtruu1op 348 12 expression expression NN cord-019051-gtruu1op 348 13 of of IN cord-019051-gtruu1op 348 14 E1A e1a NN cord-019051-gtruu1op 348 15 correlated correlate VBN cord-019051-gtruu1op 348 16 with with IN cord-019051-gtruu1op 348 17 disease disease NN cord-019051-gtruu1op 348 18 severity severity NN cord-019051-gtruu1op 348 19 [ [ -LRB- cord-019051-gtruu1op 348 20 125 125 CD cord-019051-gtruu1op 348 21 ] ] -RRB- cord-019051-gtruu1op 348 22 [ [ -LRB- cord-019051-gtruu1op 348 23 126 126 CD cord-019051-gtruu1op 348 24 ] ] -RRB- cord-019051-gtruu1op 348 25 [ [ -LRB- cord-019051-gtruu1op 348 26 127 127 CD cord-019051-gtruu1op 348 27 ] ] -RRB- cord-019051-gtruu1op 348 28 . . . cord-019051-gtruu1op 349 1 In in IN cord-019051-gtruu1op 349 2 response response NN cord-019051-gtruu1op 349 3 to to IN cord-019051-gtruu1op 349 4 inflammatory inflammatory JJ cord-019051-gtruu1op 349 5 stimuli stimulus NNS cord-019051-gtruu1op 349 6 , , , cord-019051-gtruu1op 349 7 E1A e1a NN cord-019051-gtruu1op 349 8 increases increase VBZ cord-019051-gtruu1op 349 9 ICAM-1 icam-1 NN cord-019051-gtruu1op 349 10 and and CC cord-019051-gtruu1op 349 11 IL-8 IL-8 NNP cord-019051-gtruu1op 349 12 expression expression NN cord-019051-gtruu1op 349 13 along along IN cord-019051-gtruu1op 349 14 with with IN cord-019051-gtruu1op 349 15 nuclear nuclear JJ cord-019051-gtruu1op 349 16 factor factor NN cord-019051-gtruu1op 349 17 - - HYPH cord-019051-gtruu1op 349 18 B b NN cord-019051-gtruu1op 349 19 ( ( -LRB- cord-019051-gtruu1op 349 20 NF nf NN cord-019051-gtruu1op 349 21 - - HYPH cord-019051-gtruu1op 349 22 B b NN cord-019051-gtruu1op 349 23 ) ) -RRB- cord-019051-gtruu1op 349 24 activation activation NN cord-019051-gtruu1op 349 25 in in IN cord-019051-gtruu1op 349 26 lung lung NN cord-019051-gtruu1op 349 27 epithelial epithelial JJ cord-019051-gtruu1op 349 28 cells cell NNS cord-019051-gtruu1op 349 29 ( ( -LRB- cord-019051-gtruu1op 349 30 [ [ -LRB- cord-019051-gtruu1op 349 31 128 128 CD cord-019051-gtruu1op 349 32 ] ] -RRB- cord-019051-gtruu1op 349 33 , , , cord-019051-gtruu1op 349 34 reviewed review VBN cord-019051-gtruu1op 349 35 in in IN cord-019051-gtruu1op 349 36 [ [ -LRB- cord-019051-gtruu1op 349 37 113 113 CD cord-019051-gtruu1op 349 38 ] ] -RRB- cord-019051-gtruu1op 349 39 ) ) -RRB- cord-019051-gtruu1op 349 40 . . . cord-019051-gtruu1op 350 1 While while IN cord-019051-gtruu1op 350 2 these these DT cord-019051-gtruu1op 350 3 factors factor NNS cord-019051-gtruu1op 350 4 support support VBP cord-019051-gtruu1op 350 5 emphysema emphysema NN cord-019051-gtruu1op 350 6 , , , cord-019051-gtruu1op 350 7 E1A e1a VB cord-019051-gtruu1op 350 8 up up RB cord-019051-gtruu1op 350 9 - - HYPH cord-019051-gtruu1op 350 10 regulates regulate NNS cord-019051-gtruu1op 350 11 transforming transform VBG cord-019051-gtruu1op 350 12 growth growth NN cord-019051-gtruu1op 351 1 factor-1 factor-1 NNP cord-019051-gtruu1op 352 1 ( ( -LRB- cord-019051-gtruu1op 352 2 TGF-1 TGF-1 NNP cord-019051-gtruu1op 352 3 ) ) -RRB- cord-019051-gtruu1op 353 1 in in IN cord-019051-gtruu1op 353 2 bronchiolar bronchiolar JJ cord-019051-gtruu1op 353 3 epithelial epithelial JJ cord-019051-gtruu1op 353 4 cells cell NNS cord-019051-gtruu1op 353 5 [ [ -LRB- cord-019051-gtruu1op 353 6 129 129 CD cord-019051-gtruu1op 353 7 ] ] -RRB- cord-019051-gtruu1op 353 8 , , , cord-019051-gtruu1op 353 9 supporting support VBG cord-019051-gtruu1op 353 10 a a DT cord-019051-gtruu1op 353 11 role role NN cord-019051-gtruu1op 353 12 for for IN cord-019051-gtruu1op 353 13 E1A E1A NNP cord-019051-gtruu1op 353 14 in in IN cord-019051-gtruu1op 353 15 airway airway NN cord-019051-gtruu1op 353 16 remodeling remodeling NN cord-019051-gtruu1op 353 17 [ [ -LRB- cord-019051-gtruu1op 353 18 130 130 CD cord-019051-gtruu1op 353 19 ] ] -RRB- cord-019051-gtruu1op 353 20 . . . cord-019051-gtruu1op 354 1 In in IN cord-019051-gtruu1op 354 2 summary summary NN cord-019051-gtruu1op 354 3 , , , cord-019051-gtruu1op 354 4 adenoviruses adenovirus NNS cord-019051-gtruu1op 354 5 are be VBP cord-019051-gtruu1op 354 6 pathogens pathogen NNS cord-019051-gtruu1op 354 7 that that WDT cord-019051-gtruu1op 354 8 frequently frequently RB cord-019051-gtruu1op 354 9 cause cause VBP cord-019051-gtruu1op 354 10 mild mild JJ cord-019051-gtruu1op 354 11 or or CC cord-019051-gtruu1op 354 12 severe severe JJ cord-019051-gtruu1op 354 13 acute acute JJ cord-019051-gtruu1op 354 14 infections infection NNS cord-019051-gtruu1op 354 15 of of IN cord-019051-gtruu1op 354 16 the the DT cord-019051-gtruu1op 354 17 respiratory respiratory JJ cord-019051-gtruu1op 354 18 tract tract NN cord-019051-gtruu1op 354 19 . . . cord-019051-gtruu1op 355 1 The the DT cord-019051-gtruu1op 355 2 importance importance NN cord-019051-gtruu1op 355 3 of of IN cord-019051-gtruu1op 355 4 adenovirus adenovirus NN cord-019051-gtruu1op 355 5 infections infection NNS cord-019051-gtruu1op 355 6 , , , cord-019051-gtruu1op 355 7 however however RB cord-019051-gtruu1op 355 8 , , , cord-019051-gtruu1op 355 9 goes go VBZ cord-019051-gtruu1op 355 10 beyond beyond IN cord-019051-gtruu1op 355 11 acute acute JJ cord-019051-gtruu1op 355 12 airway airway NN cord-019051-gtruu1op 355 13 disease disease NN cord-019051-gtruu1op 355 14 . . . cord-019051-gtruu1op 356 1 Adenoviruses adenovirus NNS cord-019051-gtruu1op 356 2 are be VBP cord-019051-gtruu1op 356 3 non non JJ cord-019051-gtruu1op 356 4 - - JJ cord-019051-gtruu1op 356 5 enveloped enveloped JJ cord-019051-gtruu1op 356 6 pathogens pathogen NNS cord-019051-gtruu1op 356 7 and and CC cord-019051-gtruu1op 356 8 thus thus RB cord-019051-gtruu1op 356 9 very very RB cord-019051-gtruu1op 356 10 stable stable JJ cord-019051-gtruu1op 356 11 to to IN cord-019051-gtruu1op 356 12 chemical chemical JJ cord-019051-gtruu1op 356 13 or or CC cord-019051-gtruu1op 356 14 physical physical JJ cord-019051-gtruu1op 356 15 agents agent NNS cord-019051-gtruu1op 356 16 and and CC cord-019051-gtruu1op 356 17 adverse adverse JJ cord-019051-gtruu1op 356 18 pH ph NN cord-019051-gtruu1op 356 19 conditions condition NNS cord-019051-gtruu1op 356 20 . . . cord-019051-gtruu1op 357 1 It -PRON- PRP cord-019051-gtruu1op 357 2 is be VBZ cord-019051-gtruu1op 357 3 believed believe VBN cord-019051-gtruu1op 357 4 that that IN cord-019051-gtruu1op 357 5 respiratory respiratory JJ cord-019051-gtruu1op 357 6 adenoviruses adenovirus NNS cord-019051-gtruu1op 357 7 are be VBP cord-019051-gtruu1op 357 8 mainly mainly RB cord-019051-gtruu1op 357 9 spread spread VBN cord-019051-gtruu1op 357 10 via via IN cord-019051-gtruu1op 357 11 aerosols aerosol NNS cord-019051-gtruu1op 357 12 ; ; : cord-019051-gtruu1op 357 13 however however RB cord-019051-gtruu1op 357 14 , , , cord-019051-gtruu1op 357 15 other other JJ cord-019051-gtruu1op 357 16 routes route NNS cord-019051-gtruu1op 357 17 ( ( -LRB- cord-019051-gtruu1op 357 18 fecal fecal JJ cord-019051-gtruu1op 357 19 , , , cord-019051-gtruu1op 357 20 waterborne waterborne JJ cord-019051-gtruu1op 357 21 ) ) -RRB- cord-019051-gtruu1op 357 22 also also RB cord-019051-gtruu1op 357 23 frequently frequently RB cord-019051-gtruu1op 357 24 lead lead VBP cord-019051-gtruu1op 357 25 to to IN cord-019051-gtruu1op 357 26 infection infection NN cord-019051-gtruu1op 357 27 . . . cord-019051-gtruu1op 358 1 Antibodies antibody NNS cord-019051-gtruu1op 358 2 to to IN cord-019051-gtruu1op 358 3 one one CD cord-019051-gtruu1op 358 4 or or CC cord-019051-gtruu1op 358 5 more more JJR cord-019051-gtruu1op 358 6 adenoviruses adenovirus NNS cord-019051-gtruu1op 358 7 are be VBP cord-019051-gtruu1op 358 8 found find VBN cord-019051-gtruu1op 358 9 in in IN cord-019051-gtruu1op 358 10 approximately approximately RB cord-019051-gtruu1op 358 11 50 50 CD cord-019051-gtruu1op 358 12 % % NN cord-019051-gtruu1op 358 13 of of IN cord-019051-gtruu1op 358 14 infants infant NNS cord-019051-gtruu1op 358 15 and and CC cord-019051-gtruu1op 358 16 nearly nearly RB cord-019051-gtruu1op 358 17 100 100 CD cord-019051-gtruu1op 358 18 % % NN cord-019051-gtruu1op 358 19 of of IN cord-019051-gtruu1op 358 20 adults adult NNS cord-019051-gtruu1op 358 21 and and CC cord-019051-gtruu1op 358 22 since since IN cord-019051-gtruu1op 358 23 there there EX cord-019051-gtruu1op 358 24 are be VBP cord-019051-gtruu1op 358 25 many many JJ cord-019051-gtruu1op 358 26 different different JJ cord-019051-gtruu1op 358 27 types type NNS cord-019051-gtruu1op 358 28 of of IN cord-019051-gtruu1op 358 29 adenovirus adenovirus NN cord-019051-gtruu1op 358 30 , , , cord-019051-gtruu1op 358 31 repeated repeat VBN cord-019051-gtruu1op 358 32 adenoviral adenoviral JJ cord-019051-gtruu1op 358 33 infections infection NNS cord-019051-gtruu1op 358 34 can can MD cord-019051-gtruu1op 358 35 occur occur VB cord-019051-gtruu1op 358 36 [ [ -LRB- cord-019051-gtruu1op 358 37 109 109 CD cord-019051-gtruu1op 358 38 , , , cord-019051-gtruu1op 358 39 131 131 CD cord-019051-gtruu1op 358 40 , , , cord-019051-gtruu1op 358 41 132 132 CD cord-019051-gtruu1op 358 42 ] ] -RRB- cord-019051-gtruu1op 358 43 . . . cord-019051-gtruu1op 359 1 Although although IN cord-019051-gtruu1op 359 2 adenovirus adenovirus NN cord-019051-gtruu1op 359 3 infections infection NNS cord-019051-gtruu1op 359 4 can can MD cord-019051-gtruu1op 359 5 occur occur VB cord-019051-gtruu1op 359 6 at at IN cord-019051-gtruu1op 359 7 any any DT cord-019051-gtruu1op 359 8 time time NN cord-019051-gtruu1op 359 9 of of IN cord-019051-gtruu1op 359 10 the the DT cord-019051-gtruu1op 359 11 year year NN cord-019051-gtruu1op 359 12 , , , cord-019051-gtruu1op 359 13 respiratory respiratory JJ cord-019051-gtruu1op 359 14 tract tract NN cord-019051-gtruu1op 359 15 disease disease NN cord-019051-gtruu1op 359 16 caused cause VBN cord-019051-gtruu1op 359 17 by by IN cord-019051-gtruu1op 359 18 adenovirus adenovirus NN cord-019051-gtruu1op 359 19 is be VBZ cord-019051-gtruu1op 359 20 more more RBR cord-019051-gtruu1op 359 21 common common JJ cord-019051-gtruu1op 359 22 in in IN cord-019051-gtruu1op 359 23 late late JJ cord-019051-gtruu1op 359 24 winter winter NN cord-019051-gtruu1op 359 25 , , , cord-019051-gtruu1op 359 26 spring spring NN cord-019051-gtruu1op 359 27 , , , cord-019051-gtruu1op 359 28 and and CC cord-019051-gtruu1op 359 29 early early JJ cord-019051-gtruu1op 359 30 summer summer NN cord-019051-gtruu1op 359 31 [ [ -LRB- cord-019051-gtruu1op 359 32 106 106 CD cord-019051-gtruu1op 359 33 ] ] -RRB- cord-019051-gtruu1op 359 34 . . . cord-019051-gtruu1op 360 1 Virological virological JJ cord-019051-gtruu1op 360 2 diagnosis diagnosis NN cord-019051-gtruu1op 360 3 can can MD cord-019051-gtruu1op 360 4 be be VB cord-019051-gtruu1op 360 5 performed perform VBN cord-019051-gtruu1op 360 6 using use VBG cord-019051-gtruu1op 360 7 a a DT cord-019051-gtruu1op 360 8 variety variety NN cord-019051-gtruu1op 360 9 of of IN cord-019051-gtruu1op 360 10 molecular molecular JJ cord-019051-gtruu1op 360 11 or or CC cord-019051-gtruu1op 360 12 immunological immunological JJ cord-019051-gtruu1op 360 13 approaches approach NNS cord-019051-gtruu1op 360 14 . . . cord-019051-gtruu1op 361 1 This this DT cord-019051-gtruu1op 361 2 is be VBZ cord-019051-gtruu1op 361 3 , , , cord-019051-gtruu1op 361 4 however however RB cord-019051-gtruu1op 361 5 , , , cord-019051-gtruu1op 361 6 only only RB cord-019051-gtruu1op 361 7 important important JJ cord-019051-gtruu1op 361 8 in in IN cord-019051-gtruu1op 361 9 the the DT cord-019051-gtruu1op 361 10 context context NN cord-019051-gtruu1op 361 11 of of IN cord-019051-gtruu1op 361 12 severe severe JJ cord-019051-gtruu1op 361 13 or or CC cord-019051-gtruu1op 361 14 epidemic epidemic JJ cord-019051-gtruu1op 361 15 diseases disease NNS cord-019051-gtruu1op 361 16 . . . cord-019051-gtruu1op 362 1 Development development NN cord-019051-gtruu1op 362 2 efforts effort NNS cord-019051-gtruu1op 362 3 for for IN cord-019051-gtruu1op 362 4 vaccines vaccine NNS cord-019051-gtruu1op 362 5 were be VBD cord-019051-gtruu1op 362 6 discontinued discontinue VBN cord-019051-gtruu1op 362 7 [ [ -LRB- cord-019051-gtruu1op 362 8 133 133 CD cord-019051-gtruu1op 362 9 ] ] -RRB- cord-019051-gtruu1op 362 10 . . . cord-019051-gtruu1op 363 1 Antiviral antiviral JJ cord-019051-gtruu1op 363 2 therapy therapy NN cord-019051-gtruu1op 363 3 is be VBZ cord-019051-gtruu1op 363 4 only only RB cord-019051-gtruu1op 363 5 important important JJ cord-019051-gtruu1op 363 6 in in IN cord-019051-gtruu1op 363 7 infected infected JJ cord-019051-gtruu1op 363 8 immunocompromised immunocompromised JJ cord-019051-gtruu1op 363 9 patients patient NNS cord-019051-gtruu1op 363 10 . . . cord-019051-gtruu1op 364 1 In in IN cord-019051-gtruu1op 364 2 these these DT cord-019051-gtruu1op 364 3 patients patient NNS cord-019051-gtruu1op 364 4 , , , cord-019051-gtruu1op 364 5 cidofovir cidofovir NNP cord-019051-gtruu1op 364 6 has have VBZ cord-019051-gtruu1op 364 7 shown show VBN cord-019051-gtruu1op 364 8 some some DT cord-019051-gtruu1op 364 9 promise promise NN cord-019051-gtruu1op 364 10 [ [ -LRB- cord-019051-gtruu1op 364 11 122 122 CD cord-019051-gtruu1op 364 12 ] ] -RRB- cord-019051-gtruu1op 364 13 . . . cord-019051-gtruu1op 365 1 Human human JJ cord-019051-gtruu1op 365 2 metapneumovirus metapneumovirus NNP cord-019051-gtruu1op 365 3 ( ( -LRB- cord-019051-gtruu1op 365 4 HMPV HMPV NNP cord-019051-gtruu1op 365 5 ) ) -RRB- cord-019051-gtruu1op 365 6 was be VBD cord-019051-gtruu1op 365 7 identified identify VBN cord-019051-gtruu1op 365 8 in in IN cord-019051-gtruu1op 365 9 2001 2001 CD cord-019051-gtruu1op 365 10 [ [ -LRB- cord-019051-gtruu1op 365 11 134 134 CD cord-019051-gtruu1op 365 12 ] ] -RRB- cord-019051-gtruu1op 365 13 , , , cord-019051-gtruu1op 365 14 and and CC cord-019051-gtruu1op 365 15 is be VBZ cord-019051-gtruu1op 365 16 today today NN cord-019051-gtruu1op 365 17 considered consider VBN cord-019051-gtruu1op 365 18 as as IN cord-019051-gtruu1op 365 19 a a DT cord-019051-gtruu1op 365 20 major major JJ cord-019051-gtruu1op 365 21 cause cause NN cord-019051-gtruu1op 365 22 of of IN cord-019051-gtruu1op 365 23 acute acute JJ cord-019051-gtruu1op 365 24 respiratory respiratory JJ cord-019051-gtruu1op 365 25 infections infection NNS cord-019051-gtruu1op 365 26 worldwide worldwide RB cord-019051-gtruu1op 365 27 , , , cord-019051-gtruu1op 365 28 especially especially RB cord-019051-gtruu1op 365 29 in in IN cord-019051-gtruu1op 365 30 children child NNS cord-019051-gtruu1op 365 31 . . . cord-019051-gtruu1op 366 1 Virtually virtually RB cord-019051-gtruu1op 366 2 all all DT cord-019051-gtruu1op 366 3 children child NNS cord-019051-gtruu1op 366 4 have have VBP cord-019051-gtruu1op 366 5 experienced experience VBN cord-019051-gtruu1op 366 6 an an DT cord-019051-gtruu1op 366 7 infection infection NN cord-019051-gtruu1op 366 8 with with IN cord-019051-gtruu1op 366 9 HMPV HMPV NNP cord-019051-gtruu1op 366 10 by by IN cord-019051-gtruu1op 366 11 the the DT cord-019051-gtruu1op 366 12 age age NN cord-019051-gtruu1op 366 13 of of IN cord-019051-gtruu1op 366 14 5 5 CD cord-019051-gtruu1op 366 15 - - SYM cord-019051-gtruu1op 366 16 10 10 CD cord-019051-gtruu1op 366 17 years year NNS cord-019051-gtruu1op 366 18 ( ( -LRB- cord-019051-gtruu1op 366 19 reviewed review VBN cord-019051-gtruu1op 366 20 in in IN cord-019051-gtruu1op 366 21 [ [ -LRB- cord-019051-gtruu1op 366 22 135 135 CD cord-019051-gtruu1op 366 23 ] ] -RRB- cord-019051-gtruu1op 366 24 ) ) -RRB- cord-019051-gtruu1op 366 25 . . . cord-019051-gtruu1op 367 1 HMPV HMPV NNP cord-019051-gtruu1op 367 2 is be VBZ cord-019051-gtruu1op 367 3 a a DT cord-019051-gtruu1op 367 4 member member NN cord-019051-gtruu1op 367 5 of of IN cord-019051-gtruu1op 367 6 the the DT cord-019051-gtruu1op 367 7 order order NN cord-019051-gtruu1op 367 8 Mononegavirales Mononegavirales NNP cord-019051-gtruu1op 367 9 , , , cord-019051-gtruu1op 367 10 family family NN cord-019051-gtruu1op 367 11 Paramyxoviridae Paramyxoviridae NNP cord-019051-gtruu1op 367 12 , , , cord-019051-gtruu1op 367 13 subfamily subfamily NN cord-019051-gtruu1op 367 14 Pneumovirinae Pneumovirinae NNP cord-019051-gtruu1op 367 15 ( ( -LRB- cord-019051-gtruu1op 367 16 as as IN cord-019051-gtruu1op 367 17 is be VBZ cord-019051-gtruu1op 367 18 RSV RSV NNP cord-019051-gtruu1op 367 19 ) ) -RRB- cord-019051-gtruu1op 367 20 , , . cord-019051-gtruu1op 368 1 genus genus NNP cord-019051-gtruu1op 368 2 Metapneumovirus Metapneumovirus NNP cord-019051-gtruu1op 368 3 [ [ -LRB- cord-019051-gtruu1op 368 4 136 136 CD cord-019051-gtruu1op 368 5 ] ] -RRB- cord-019051-gtruu1op 368 6 . . . cord-019051-gtruu1op 369 1 There there EX cord-019051-gtruu1op 369 2 are be VBP cord-019051-gtruu1op 369 3 two two CD cord-019051-gtruu1op 369 4 major major JJ cord-019051-gtruu1op 369 5 groups group NNS cord-019051-gtruu1op 369 6 and and CC cord-019051-gtruu1op 369 7 at at IN cord-019051-gtruu1op 369 8 least least JJS cord-019051-gtruu1op 369 9 four four CD cord-019051-gtruu1op 369 10 subgroups subgroup NNS cord-019051-gtruu1op 369 11 of of IN cord-019051-gtruu1op 369 12 HMPV HMPV NNP cord-019051-gtruu1op 369 13 [ [ -LRB- cord-019051-gtruu1op 369 14 137 137 CD cord-019051-gtruu1op 369 15 ] ] -RRB- cord-019051-gtruu1op 369 16 [ [ -LRB- cord-019051-gtruu1op 369 17 138 138 CD cord-019051-gtruu1op 369 18 ] ] -RRB- cord-019051-gtruu1op 370 1 [ [ -LRB- cord-019051-gtruu1op 370 2 139 139 CD cord-019051-gtruu1op 370 3 ] ] -RRB- cord-019051-gtruu1op 370 4 [ [ -LRB- cord-019051-gtruu1op 370 5 140 140 CD cord-019051-gtruu1op 370 6 ] ] -RRB- cord-019051-gtruu1op 370 7 . . . cord-019051-gtruu1op 371 1 HMPV hmpv NN cord-019051-gtruu1op 371 2 particles particle NNS cord-019051-gtruu1op 371 3 are be VBP cord-019051-gtruu1op 371 4 enveloped envelop VBN cord-019051-gtruu1op 371 5 , , , cord-019051-gtruu1op 371 6 pleomorphic pleomorphic JJ cord-019051-gtruu1op 371 7 , , , cord-019051-gtruu1op 371 8 filamenteous filamenteous JJ cord-019051-gtruu1op 371 9 and and CC cord-019051-gtruu1op 371 10 spherical spherical JJ cord-019051-gtruu1op 371 11 and and CC cord-019051-gtruu1op 371 12 have have VBP cord-019051-gtruu1op 371 13 a a DT cord-019051-gtruu1op 371 14 mean mean JJ cord-019051-gtruu1op 371 15 diameter diameter NN cord-019051-gtruu1op 371 16 of of IN cord-019051-gtruu1op 371 17 approximately approximately RB cord-019051-gtruu1op 371 18 210 210 CD cord-019051-gtruu1op 371 19 nm nm NN cord-019051-gtruu1op 371 20 [ [ -LRB- cord-019051-gtruu1op 371 21 137 137 CD cord-019051-gtruu1op 371 22 ] ] -RRB- cord-019051-gtruu1op 371 23 . . . cord-019051-gtruu1op 372 1 The the DT cord-019051-gtruu1op 372 2 genome genome NN cord-019051-gtruu1op 372 3 consists consist VBZ cord-019051-gtruu1op 372 4 of of IN cord-019051-gtruu1op 372 5 a a DT cord-019051-gtruu1op 372 6 single single RB cord-019051-gtruu1op 372 7 - - HYPH cord-019051-gtruu1op 372 8 stranded strand VBN cord-019051-gtruu1op 372 9 negative negative JJ cord-019051-gtruu1op 372 10 RNA rna NN cord-019051-gtruu1op 372 11 of of IN cord-019051-gtruu1op 372 12 approximately approximately RB cord-019051-gtruu1op 372 13 13.3 13.3 CD cord-019051-gtruu1op 372 14 kb kb NNS cord-019051-gtruu1op 372 15 and and CC cord-019051-gtruu1op 372 16 contains contain VBZ cord-019051-gtruu1op 372 17 eight eight CD cord-019051-gtruu1op 372 18 genes gene NNS cord-019051-gtruu1op 372 19 in in IN cord-019051-gtruu1op 372 20 the the DT cord-019051-gtruu1op 372 21 order order NN cord-019051-gtruu1op 372 22 3'N 3'N NNP cord-019051-gtruu1op 372 23 - - HYPH cord-019051-gtruu1op 372 24 P P NNP cord-019051-gtruu1op 372 25 - - HYPH cord-019051-gtruu1op 372 26 M M NNP cord-019051-gtruu1op 372 27 - - HYPH cord-019051-gtruu1op 372 28 F F NNP cord-019051-gtruu1op 372 29 - - HYPH cord-019051-gtruu1op 372 30 M2-SH M2-SH NNP cord-019051-gtruu1op 372 31 - - HYPH cord-019051-gtruu1op 372 32 G G NNP cord-019051-gtruu1op 372 33 - - HYPH cord-019051-gtruu1op 372 34 L-5 L-5 NNP cord-019051-gtruu1op 372 35 ' ' POS cord-019051-gtruu1op 372 36 coding code VBG cord-019051-gtruu1op 372 37 for for IN cord-019051-gtruu1op 372 38 a a DT cord-019051-gtruu1op 372 39 nucleoprotein nucleoprotein NNP cord-019051-gtruu1op 372 40 ( ( -LRB- cord-019051-gtruu1op 372 41 N N NNP cord-019051-gtruu1op 372 42 ) ) -RRB- cord-019051-gtruu1op 372 43 , , , cord-019051-gtruu1op 372 44 a a DT cord-019051-gtruu1op 372 45 phosphoprotein phosphoprotein NN cord-019051-gtruu1op 372 46 ( ( -LRB- cord-019051-gtruu1op 372 47 P p NN cord-019051-gtruu1op 372 48 ) ) -RRB- cord-019051-gtruu1op 372 49 , , , cord-019051-gtruu1op 372 50 matrix matrix NN cord-019051-gtruu1op 372 51 protein protein NN cord-019051-gtruu1op 372 52 ( ( -LRB- cord-019051-gtruu1op 372 53 M M NNP cord-019051-gtruu1op 372 54 ) ) -RRB- cord-019051-gtruu1op 372 55 , , , cord-019051-gtruu1op 372 56 fusion fusion NN cord-019051-gtruu1op 372 57 protein protein NN cord-019051-gtruu1op 372 58 ( ( -LRB- cord-019051-gtruu1op 372 59 F F NNP cord-019051-gtruu1op 372 60 ) ) -RRB- cord-019051-gtruu1op 372 61 , , , cord-019051-gtruu1op 372 62 a a DT cord-019051-gtruu1op 372 63 transcription transcription NN cord-019051-gtruu1op 372 64 elongation elongation NN cord-019051-gtruu1op 372 65 factor factor NN cord-019051-gtruu1op 372 66 ( ( -LRB- cord-019051-gtruu1op 372 67 M2 M2 NNP cord-019051-gtruu1op 372 68 - - HYPH cord-019051-gtruu1op 372 69 1 1 CD cord-019051-gtruu1op 372 70 ) ) -RRB- cord-019051-gtruu1op 372 71 , , , cord-019051-gtruu1op 372 72 a a DT cord-019051-gtruu1op 372 73 protein protein NN cord-019051-gtruu1op 372 74 regulating regulate VBG cord-019051-gtruu1op 372 75 RNA RNA NNP cord-019051-gtruu1op 372 76 synthesis synthesis NN cord-019051-gtruu1op 372 77 ( ( -LRB- cord-019051-gtruu1op 372 78 M2 M2 NNP cord-019051-gtruu1op 372 79 - - HYPH cord-019051-gtruu1op 372 80 2 2 CD cord-019051-gtruu1op 372 81 ) ) -RRB- cord-019051-gtruu1op 372 82 , , , cord-019051-gtruu1op 372 83 a a DT cord-019051-gtruu1op 372 84 small small JJ cord-019051-gtruu1op 372 85 hydrophobic hydrophobic JJ cord-019051-gtruu1op 372 86 protein protein NN cord-019051-gtruu1op 372 87 ( ( -LRB- cord-019051-gtruu1op 372 88 SH SH NNP cord-019051-gtruu1op 372 89 ) ) -RRB- cord-019051-gtruu1op 372 90 , , , cord-019051-gtruu1op 372 91 attachment attachment NN cord-019051-gtruu1op 372 92 protein protein NN cord-019051-gtruu1op 372 93 ( ( -LRB- cord-019051-gtruu1op 372 94 G G NNP cord-019051-gtruu1op 372 95 ) ) -RRB- cord-019051-gtruu1op 372 96 , , , cord-019051-gtruu1op 372 97 a a DT cord-019051-gtruu1op 372 98 polymerase polymerase NN cord-019051-gtruu1op 372 99 subunit subunit NN cord-019051-gtruu1op 372 100 ( ( -LRB- cord-019051-gtruu1op 372 101 L l NN cord-019051-gtruu1op 372 102 ) ) -RRB- cord-019051-gtruu1op 372 103 and and CC cord-019051-gtruu1op 372 104 probably probably RB cord-019051-gtruu1op 372 105 additional additional JJ cord-019051-gtruu1op 372 106 proteins protein NNS cord-019051-gtruu1op 372 107 [ [ -LRB- cord-019051-gtruu1op 372 108 141 141 CD cord-019051-gtruu1op 372 109 , , , cord-019051-gtruu1op 372 110 142 142 CD cord-019051-gtruu1op 372 111 ] ] -RRB- cord-019051-gtruu1op 372 112 . . . cord-019051-gtruu1op 373 1 The the DT cord-019051-gtruu1op 373 2 F F NNP cord-019051-gtruu1op 373 3 protein protein NN cord-019051-gtruu1op 373 4 is be VBZ cord-019051-gtruu1op 373 5 the the DT cord-019051-gtruu1op 373 6 major major JJ cord-019051-gtruu1op 373 7 immunogenic immunogenic JJ cord-019051-gtruu1op 373 8 viral viral JJ cord-019051-gtruu1op 373 9 protein protein NN cord-019051-gtruu1op 373 10 [ [ -LRB- cord-019051-gtruu1op 373 11 143 143 CD cord-019051-gtruu1op 373 12 ] ] -RRB- cord-019051-gtruu1op 373 13 . . . cord-019051-gtruu1op 374 1 Replication replication NN cord-019051-gtruu1op 374 2 is be VBZ cord-019051-gtruu1op 374 3 generally generally RB cord-019051-gtruu1op 374 4 comparable comparable JJ cord-019051-gtruu1op 374 5 to to IN cord-019051-gtruu1op 374 6 that that DT cord-019051-gtruu1op 374 7 of of IN cord-019051-gtruu1op 374 8 other other JJ cord-019051-gtruu1op 374 9 members member NNS cord-019051-gtruu1op 374 10 of of IN cord-019051-gtruu1op 374 11 Mononegavirales Mononegavirales NNP cord-019051-gtruu1op 374 12 . . . cord-019051-gtruu1op 375 1 This this DT cord-019051-gtruu1op 375 2 virus virus NN cord-019051-gtruu1op 375 3 infection infection NN cord-019051-gtruu1op 375 4 occurs occur VBZ cord-019051-gtruu1op 375 5 primarily primarily RB cord-019051-gtruu1op 375 6 during during IN cord-019051-gtruu1op 375 7 winter winter NN cord-019051-gtruu1op 375 8 months month NNS cord-019051-gtruu1op 375 9 or or CC cord-019051-gtruu1op 375 10 early early JJ cord-019051-gtruu1op 375 11 spring spring NN cord-019051-gtruu1op 375 12 and and CC cord-019051-gtruu1op 375 13 can can MD cord-019051-gtruu1op 375 14 manifest manifest VB cord-019051-gtruu1op 375 15 as as IN cord-019051-gtruu1op 375 16 both both CC cord-019051-gtruu1op 375 17 upper upper JJ cord-019051-gtruu1op 375 18 and and CC cord-019051-gtruu1op 375 19 lower low JJR cord-019051-gtruu1op 375 20 respiratory respiratory JJ cord-019051-gtruu1op 375 21 tract tract NN cord-019051-gtruu1op 375 22 disease disease NN cord-019051-gtruu1op 375 23 [ [ -LRB- cord-019051-gtruu1op 375 24 144 144 CD cord-019051-gtruu1op 375 25 ] ] -RRB- cord-019051-gtruu1op 375 26 . . . cord-019051-gtruu1op 376 1 After after IN cord-019051-gtruu1op 376 2 a a DT cord-019051-gtruu1op 376 3 severe severe JJ cord-019051-gtruu1op 376 4 HMPV hmpv NN cord-019051-gtruu1op 376 5 infection infection NN cord-019051-gtruu1op 376 6 , , , cord-019051-gtruu1op 376 7 virus virus NN cord-019051-gtruu1op 376 8 was be VBD cord-019051-gtruu1op 376 9 detected detect VBN cord-019051-gtruu1op 376 10 in in IN cord-019051-gtruu1op 376 11 alveolar alveolar NN cord-019051-gtruu1op 376 12 and and CC cord-019051-gtruu1op 376 13 airway airway NN cord-019051-gtruu1op 376 14 epithelial epithelial JJ cord-019051-gtruu1op 376 15 cells cell NNS cord-019051-gtruu1op 376 16 [ [ -LRB- cord-019051-gtruu1op 376 17 145 145 CD cord-019051-gtruu1op 376 18 ] ] -RRB- cord-019051-gtruu1op 376 19 . . . cord-019051-gtruu1op 377 1 It -PRON- PRP cord-019051-gtruu1op 377 2 was be VBD cord-019051-gtruu1op 377 3 also also RB cord-019051-gtruu1op 377 4 reported report VBN cord-019051-gtruu1op 377 5 in in IN cord-019051-gtruu1op 377 6 this this DT cord-019051-gtruu1op 377 7 study study NN cord-019051-gtruu1op 377 8 that that IN cord-019051-gtruu1op 377 9 the the DT cord-019051-gtruu1op 377 10 virus virus NN cord-019051-gtruu1op 377 11 caused cause VBD cord-019051-gtruu1op 377 12 acute acute JJ cord-019051-gtruu1op 377 13 organizing organize VBG cord-019051-gtruu1op 377 14 lung lung NN cord-019051-gtruu1op 377 15 injury injury NN cord-019051-gtruu1op 377 16 , , , cord-019051-gtruu1op 377 17 tissue tissue NN cord-019051-gtruu1op 377 18 damage damage NN cord-019051-gtruu1op 377 19 and and CC cord-019051-gtruu1op 377 20 , , , cord-019051-gtruu1op 377 21 which which WDT cord-019051-gtruu1op 377 22 is be VBZ cord-019051-gtruu1op 377 23 not not RB cord-019051-gtruu1op 377 24 observed observe VBN cord-019051-gtruu1op 377 25 in in IN cord-019051-gtruu1op 377 26 other other JJ cord-019051-gtruu1op 377 27 paramyxovirus paramyxovirus JJ cord-019051-gtruu1op 377 28 infections infection NNS cord-019051-gtruu1op 377 29 , , , cord-019051-gtruu1op 377 30 induction induction NN cord-019051-gtruu1op 377 31 of of IN cord-019051-gtruu1op 377 32 smudge smudge NN cord-019051-gtruu1op 377 33 cell cell NN cord-019051-gtruu1op 377 34 formation formation NN cord-019051-gtruu1op 377 35 . . . cord-019051-gtruu1op 378 1 The the DT cord-019051-gtruu1op 378 2 clinical clinical JJ cord-019051-gtruu1op 378 3 symptoms symptom NNS cord-019051-gtruu1op 378 4 associated associate VBN cord-019051-gtruu1op 378 5 with with IN cord-019051-gtruu1op 378 6 HMPV hmpv NN cord-019051-gtruu1op 378 7 infection infection NN cord-019051-gtruu1op 378 8 are be VBP cord-019051-gtruu1op 378 9 indistinguishable indistinguishable JJ cord-019051-gtruu1op 378 10 from from IN cord-019051-gtruu1op 378 11 those those DT cord-019051-gtruu1op 378 12 of of IN cord-019051-gtruu1op 378 13 RSV RSV NNP cord-019051-gtruu1op 378 14 infection infection NN cord-019051-gtruu1op 378 15 [ [ -LRB- cord-019051-gtruu1op 378 16 146 146 CD cord-019051-gtruu1op 378 17 ] ] -RRB- cord-019051-gtruu1op 378 18 and and CC cord-019051-gtruu1op 378 19 range range VBP cord-019051-gtruu1op 378 20 from from IN cord-019051-gtruu1op 378 21 common common JJ cord-019051-gtruu1op 378 22 cold cold NN cord-019051-gtruu1op 378 23 to to IN cord-019051-gtruu1op 378 24 pneumonia pneumonia NN cord-019051-gtruu1op 378 25 . . . cord-019051-gtruu1op 379 1 Otitis otitis NN cord-019051-gtruu1op 379 2 media medium NNS cord-019051-gtruu1op 379 3 is be VBZ cord-019051-gtruu1op 379 4 observed observe VBN cord-019051-gtruu1op 379 5 in in IN cord-019051-gtruu1op 379 6 up up IN cord-019051-gtruu1op 379 7 to to TO cord-019051-gtruu1op 379 8 50 50 CD cord-019051-gtruu1op 379 9 % % NN cord-019051-gtruu1op 379 10 of of IN cord-019051-gtruu1op 379 11 the the DT cord-019051-gtruu1op 379 12 infected infect VBN cord-019051-gtruu1op 379 13 individuals individual NNS cord-019051-gtruu1op 379 14 ( ( -LRB- cord-019051-gtruu1op 379 15 reviewed review VBN cord-019051-gtruu1op 379 16 in in IN cord-019051-gtruu1op 379 17 [ [ -LRB- cord-019051-gtruu1op 379 18 135 135 CD cord-019051-gtruu1op 379 19 ] ] -RRB- cord-019051-gtruu1op 379 20 ) ) -RRB- cord-019051-gtruu1op 379 21 . . . cord-019051-gtruu1op 380 1 As as IN cord-019051-gtruu1op 380 2 for for IN cord-019051-gtruu1op 380 3 other other JJ cord-019051-gtruu1op 380 4 respiratory respiratory JJ cord-019051-gtruu1op 380 5 viruses virus NNS cord-019051-gtruu1op 380 6 , , , cord-019051-gtruu1op 380 7 HMPV HMPV NNP cord-019051-gtruu1op 380 8 may may MD cord-019051-gtruu1op 380 9 cause cause VB cord-019051-gtruu1op 380 10 exacerbation exacerbation NN cord-019051-gtruu1op 380 11 of of IN cord-019051-gtruu1op 380 12 underlying underlie VBG cord-019051-gtruu1op 380 13 chronic chronic JJ cord-019051-gtruu1op 380 14 diseases disease NNS cord-019051-gtruu1op 380 15 like like IN cord-019051-gtruu1op 380 16 asthma asthma NN cord-019051-gtruu1op 380 17 , , , cord-019051-gtruu1op 380 18 congestive congestive JJ cord-019051-gtruu1op 380 19 heart heart NN cord-019051-gtruu1op 380 20 disease disease NN cord-019051-gtruu1op 380 21 or or CC cord-019051-gtruu1op 380 22 chronic chronic JJ cord-019051-gtruu1op 380 23 obstructive obstructive JJ cord-019051-gtruu1op 380 24 pulmonary pulmonary JJ cord-019051-gtruu1op 380 25 disease disease NN cord-019051-gtruu1op 380 26 . . . cord-019051-gtruu1op 381 1 The the DT cord-019051-gtruu1op 381 2 importance importance NN cord-019051-gtruu1op 381 3 of of IN cord-019051-gtruu1op 381 4 coinfections coinfection NNS cord-019051-gtruu1op 381 5 with with IN cord-019051-gtruu1op 381 6 RSV RSV NNP cord-019051-gtruu1op 381 7 or or CC cord-019051-gtruu1op 381 8 influenza influenza NN cord-019051-gtruu1op 381 9 viruses virus NNS cord-019051-gtruu1op 381 10 is be VBZ cord-019051-gtruu1op 381 11 not not RB cord-019051-gtruu1op 381 12 clear clear JJ cord-019051-gtruu1op 381 13 ( ( -LRB- cord-019051-gtruu1op 381 14 reviewed review VBN cord-019051-gtruu1op 381 15 in in IN cord-019051-gtruu1op 381 16 [ [ -LRB- cord-019051-gtruu1op 381 17 135 135 CD cord-019051-gtruu1op 381 18 ] ] -RRB- cord-019051-gtruu1op 381 19 ) ) -RRB- cord-019051-gtruu1op 381 20 . . . cord-019051-gtruu1op 382 1 As as IN cord-019051-gtruu1op 382 2 for for IN cord-019051-gtruu1op 382 3 many many JJ cord-019051-gtruu1op 382 4 other other JJ cord-019051-gtruu1op 382 5 respiratory respiratory JJ cord-019051-gtruu1op 382 6 viruses virus NNS cord-019051-gtruu1op 382 7 , , , cord-019051-gtruu1op 382 8 serious serious JJ cord-019051-gtruu1op 382 9 disease disease NN cord-019051-gtruu1op 382 10 caused cause VBN cord-019051-gtruu1op 382 11 by by IN cord-019051-gtruu1op 382 12 HMPV HMPV NNP cord-019051-gtruu1op 382 13 is be VBZ cord-019051-gtruu1op 382 14 observed observe VBN cord-019051-gtruu1op 382 15 among among IN cord-019051-gtruu1op 382 16 immunosuppressed immunosuppressed JJ cord-019051-gtruu1op 382 17 patients patient NNS cord-019051-gtruu1op 382 18 . . . cord-019051-gtruu1op 383 1 Results result NNS cord-019051-gtruu1op 383 2 from from IN cord-019051-gtruu1op 383 3 a a DT cord-019051-gtruu1op 383 4 recent recent JJ cord-019051-gtruu1op 383 5 retrospective retrospective JJ cord-019051-gtruu1op 383 6 study study NN cord-019051-gtruu1op 383 7 suggested suggest VBD cord-019051-gtruu1op 383 8 that that IN cord-019051-gtruu1op 383 9 HMPV HMPV NNP cord-019051-gtruu1op 383 10 infection infection NN cord-019051-gtruu1op 383 11 may may MD cord-019051-gtruu1op 383 12 be be VB cord-019051-gtruu1op 383 13 an an DT cord-019051-gtruu1op 383 14 important important JJ cord-019051-gtruu1op 383 15 cause cause NN cord-019051-gtruu1op 383 16 of of IN cord-019051-gtruu1op 383 17 idiopathic idiopathic JJ cord-019051-gtruu1op 383 18 pneumonia pneumonia NN cord-019051-gtruu1op 383 19 syndrome syndrome NN cord-019051-gtruu1op 383 20 after after IN cord-019051-gtruu1op 383 21 stem stem NN cord-019051-gtruu1op 383 22 cell cell NN cord-019051-gtruu1op 383 23 transplantation transplantation NN cord-019051-gtruu1op 383 24 [ [ -LRB- cord-019051-gtruu1op 383 25 147 147 CD cord-019051-gtruu1op 383 26 ] ] -RRB- cord-019051-gtruu1op 383 27 . . . cord-019051-gtruu1op 384 1 HMPV HMPV NNP cord-019051-gtruu1op 384 2 is be VBZ cord-019051-gtruu1op 384 3 thought think VBN cord-019051-gtruu1op 384 4 to to TO cord-019051-gtruu1op 384 5 be be VB cord-019051-gtruu1op 384 6 the the DT cord-019051-gtruu1op 384 7 second second JJ cord-019051-gtruu1op 384 8 or or CC cord-019051-gtruu1op 384 9 third third JJ cord-019051-gtruu1op 384 10 cause cause NN cord-019051-gtruu1op 384 11 of of IN cord-019051-gtruu1op 384 12 severe severe JJ cord-019051-gtruu1op 384 13 acute acute JJ cord-019051-gtruu1op 384 14 respiratory respiratory JJ cord-019051-gtruu1op 384 15 tract tract NN cord-019051-gtruu1op 384 16 infection infection NN cord-019051-gtruu1op 384 17 in in IN cord-019051-gtruu1op 384 18 children child NNS cord-019051-gtruu1op 384 19 , , , cord-019051-gtruu1op 384 20 just just RB cord-019051-gtruu1op 384 21 ranking rank VBG cord-019051-gtruu1op 384 22 behind behind IN cord-019051-gtruu1op 384 23 RSV RSV NNP cord-019051-gtruu1op 384 24 and and CC cord-019051-gtruu1op 384 25 influenza influenza NN cord-019051-gtruu1op 384 26 virus virus NN cord-019051-gtruu1op 384 27 [ [ -LRB- cord-019051-gtruu1op 384 28 146 146 CD cord-019051-gtruu1op 384 29 , , , cord-019051-gtruu1op 384 30 148 148 CD cord-019051-gtruu1op 384 31 ] ] -RRB- cord-019051-gtruu1op 384 32 . . . cord-019051-gtruu1op 385 1 Infections infection NNS cord-019051-gtruu1op 385 2 occur occur VBP cord-019051-gtruu1op 385 3 very very RB cord-019051-gtruu1op 385 4 early early RB cord-019051-gtruu1op 385 5 in in IN cord-019051-gtruu1op 385 6 life life NN cord-019051-gtruu1op 385 7 and and CC cord-019051-gtruu1op 385 8 up up IN cord-019051-gtruu1op 385 9 to to TO cord-019051-gtruu1op 385 10 100 100 CD cord-019051-gtruu1op 385 11 % % NN cord-019051-gtruu1op 385 12 of of IN cord-019051-gtruu1op 385 13 children child NNS cord-019051-gtruu1op 385 14 have have VBP cord-019051-gtruu1op 385 15 experienced experience VBN cord-019051-gtruu1op 385 16 an an DT cord-019051-gtruu1op 385 17 HMPV hmpv NN cord-019051-gtruu1op 385 18 infection infection NN cord-019051-gtruu1op 385 19 by by IN cord-019051-gtruu1op 385 20 the the DT cord-019051-gtruu1op 385 21 age age NN cord-019051-gtruu1op 385 22 of of IN cord-019051-gtruu1op 385 23 10 10 CD cord-019051-gtruu1op 385 24 years year NNS cord-019051-gtruu1op 385 25 . . . cord-019051-gtruu1op 386 1 Reinfections reinfection NNS cord-019051-gtruu1op 386 2 occur occur VBP cord-019051-gtruu1op 386 3 frequently frequently RB cord-019051-gtruu1op 386 4 . . . cord-019051-gtruu1op 387 1 Incidences incidence NNS cord-019051-gtruu1op 387 2 in in IN cord-019051-gtruu1op 387 3 hospitalized hospitalize VBN cord-019051-gtruu1op 387 4 children child NNS cord-019051-gtruu1op 387 5 with with IN cord-019051-gtruu1op 387 6 acute acute JJ cord-019051-gtruu1op 387 7 respiratory respiratory JJ cord-019051-gtruu1op 387 8 tract tract NN cord-019051-gtruu1op 387 9 infection infection NN cord-019051-gtruu1op 387 10 range range NN cord-019051-gtruu1op 387 11 from from IN cord-019051-gtruu1op 387 12 5 5 CD cord-019051-gtruu1op 387 13 % % NN cord-019051-gtruu1op 387 14 to to TO cord-019051-gtruu1op 387 15 10 10 CD cord-019051-gtruu1op 387 16 % % NN cord-019051-gtruu1op 387 17 . . . cord-019051-gtruu1op 388 1 Incidence incidence NN cord-019051-gtruu1op 388 2 is be VBZ cord-019051-gtruu1op 388 3 up up IN cord-019051-gtruu1op 388 4 to to TO cord-019051-gtruu1op 388 5 20 20 CD cord-019051-gtruu1op 388 6 % % NN cord-019051-gtruu1op 388 7 in in IN cord-019051-gtruu1op 388 8 patients patient NNS cord-019051-gtruu1op 388 9 consulting consult VBG cord-019051-gtruu1op 388 10 at at IN cord-019051-gtruu1op 388 11 an an DT cord-019051-gtruu1op 388 12 outpatient outpatient NN cord-019051-gtruu1op 388 13 clinic clinic NN cord-019051-gtruu1op 388 14 ( ( -LRB- cord-019051-gtruu1op 388 15 reviewed review VBN cord-019051-gtruu1op 388 16 in in IN cord-019051-gtruu1op 388 17 [ [ -LRB- cord-019051-gtruu1op 388 18 135 135 CD cord-019051-gtruu1op 388 19 ] ] -RRB- cord-019051-gtruu1op 388 20 ) ) -RRB- cord-019051-gtruu1op 388 21 . . . cord-019051-gtruu1op 389 1 The the DT cord-019051-gtruu1op 389 2 routes route NNS cord-019051-gtruu1op 389 3 of of IN cord-019051-gtruu1op 389 4 transmission transmission NN cord-019051-gtruu1op 389 5 are be VBP cord-019051-gtruu1op 389 6 believed believe VBN cord-019051-gtruu1op 389 7 to to TO cord-019051-gtruu1op 389 8 be be VB cord-019051-gtruu1op 389 9 similar similar JJ cord-019051-gtruu1op 389 10 to to IN cord-019051-gtruu1op 389 11 those those DT cord-019051-gtruu1op 389 12 of of IN cord-019051-gtruu1op 389 13 RSV RSV NNP cord-019051-gtruu1op 389 14 ( ( -LRB- cord-019051-gtruu1op 389 15 respiratory respiratory JJ cord-019051-gtruu1op 389 16 droplets droplet NNS cord-019051-gtruu1op 389 17 , , , cord-019051-gtruu1op 389 18 hand hand NN cord-019051-gtruu1op 389 19 - - HYPH cord-019051-gtruu1op 389 20 to to IN cord-019051-gtruu1op 389 21 mouth mouth NN cord-019051-gtruu1op 389 22 or or CC cord-019051-gtruu1op 389 23 hand hand NN cord-019051-gtruu1op 389 24 - - HYPH cord-019051-gtruu1op 389 25 to to IN cord-019051-gtruu1op 389 26 eye eye NN cord-019051-gtruu1op 389 27 contact contact NN cord-019051-gtruu1op 389 28 ) ) -RRB- cord-019051-gtruu1op 389 29 [ [ -LRB- cord-019051-gtruu1op 389 30 149 149 CD cord-019051-gtruu1op 389 31 , , , cord-019051-gtruu1op 389 32 150 150 CD cord-019051-gtruu1op 389 33 ] ] -RRB- cord-019051-gtruu1op 389 34 . . . cord-019051-gtruu1op 390 1 The the DT cord-019051-gtruu1op 390 2 diagnosis diagnosis NN cord-019051-gtruu1op 390 3 of of IN cord-019051-gtruu1op 390 4 HMPV hmpv NN cord-019051-gtruu1op 390 5 infection infection NN cord-019051-gtruu1op 390 6 is be VBZ cord-019051-gtruu1op 390 7 mainly mainly RB cord-019051-gtruu1op 390 8 clinical clinical JJ cord-019051-gtruu1op 390 9 . . . cord-019051-gtruu1op 391 1 Molecular molecular JJ cord-019051-gtruu1op 391 2 diagnostic diagnostic JJ cord-019051-gtruu1op 391 3 procedures procedure NNS cord-019051-gtruu1op 391 4 are be VBP cord-019051-gtruu1op 391 5 usually usually RB cord-019051-gtruu1op 391 6 not not RB cord-019051-gtruu1op 391 7 performed perform VBN cord-019051-gtruu1op 391 8 routinely routinely RB cord-019051-gtruu1op 391 9 but but CC cord-019051-gtruu1op 391 10 are be VBP cord-019051-gtruu1op 391 11 possible possible JJ cord-019051-gtruu1op 391 12 using use VBG cord-019051-gtruu1op 391 13 standard standard JJ cord-019051-gtruu1op 391 14 technologies technology NNS cord-019051-gtruu1op 391 15 like like IN cord-019051-gtruu1op 391 16 RT RT NNP cord-019051-gtruu1op 391 17 - - HYPH cord-019051-gtruu1op 391 18 PCR PCR NNP cord-019051-gtruu1op 391 19 or or CC cord-019051-gtruu1op 391 20 immunological immunological JJ cord-019051-gtruu1op 391 21 techniques technique NNS cord-019051-gtruu1op 391 22 . . . cord-019051-gtruu1op 392 1 There there EX cord-019051-gtruu1op 392 2 is be VBZ cord-019051-gtruu1op 392 3 no no DT cord-019051-gtruu1op 392 4 specific specific JJ cord-019051-gtruu1op 392 5 antiviral antiviral JJ cord-019051-gtruu1op 392 6 treatment treatment NN cord-019051-gtruu1op 392 7 available available JJ cord-019051-gtruu1op 392 8 . . . cord-019051-gtruu1op 393 1 However however RB cord-019051-gtruu1op 393 2 , , , cord-019051-gtruu1op 393 3 ribavirin ribavirin NNP cord-019051-gtruu1op 393 4 has have VBZ cord-019051-gtruu1op 393 5 shown show VBN cord-019051-gtruu1op 393 6 some some DT cord-019051-gtruu1op 393 7 promise promise NN cord-019051-gtruu1op 393 8 [ [ -LRB- cord-019051-gtruu1op 393 9 151 151 CD cord-019051-gtruu1op 393 10 ] ] -RRB- cord-019051-gtruu1op 393 11 and and CC cord-019051-gtruu1op 393 12 monoclonal monoclonal JJ cord-019051-gtruu1op 393 13 antibodies antibody NNS cord-019051-gtruu1op 393 14 are be VBP cord-019051-gtruu1op 393 15 under under IN cord-019051-gtruu1op 393 16 development development NN cord-019051-gtruu1op 393 17 that that WDT cord-019051-gtruu1op 393 18 could could MD cord-019051-gtruu1op 393 19 potentially potentially RB cord-019051-gtruu1op 393 20 be be VB cord-019051-gtruu1op 393 21 used use VBN cord-019051-gtruu1op 393 22 to to TO cord-019051-gtruu1op 393 23 prevent prevent VB cord-019051-gtruu1op 393 24 HMPV hmpv NN cord-019051-gtruu1op 393 25 infections infection NNS cord-019051-gtruu1op 393 26 [ [ -LRB- cord-019051-gtruu1op 393 27 152 152 CD cord-019051-gtruu1op 393 28 ] ] -RRB- cord-019051-gtruu1op 393 29 . . . cord-019051-gtruu1op 394 1 Several several JJ cord-019051-gtruu1op 394 2 vaccines vaccine NNS cord-019051-gtruu1op 394 3 are be VBP cord-019051-gtruu1op 394 4 being be VBG cord-019051-gtruu1op 394 5 developed develop VBN cord-019051-gtruu1op 394 6 but but CC cord-019051-gtruu1op 394 7 are be VBP cord-019051-gtruu1op 394 8 still still RB cord-019051-gtruu1op 394 9 in in IN cord-019051-gtruu1op 394 10 an an DT cord-019051-gtruu1op 394 11 early early JJ cord-019051-gtruu1op 394 12 stage stage NN cord-019051-gtruu1op 394 13 . . . cord-019051-gtruu1op 395 1 Human human JJ cord-019051-gtruu1op 395 2 bocavirus bocavirus NNP cord-019051-gtruu1op 395 3 ( ( -LRB- cord-019051-gtruu1op 395 4 HBoV HBoV NNP cord-019051-gtruu1op 395 5 ) ) -RRB- cord-019051-gtruu1op 395 6 , , , cord-019051-gtruu1op 395 7 a a DT cord-019051-gtruu1op 395 8 parvovirus parvovirus NN cord-019051-gtruu1op 395 9 , , , cord-019051-gtruu1op 395 10 was be VBD cord-019051-gtruu1op 395 11 detected detect VBN cord-019051-gtruu1op 395 12 in in IN cord-019051-gtruu1op 395 13 children child NNS cord-019051-gtruu1op 395 14 with with IN cord-019051-gtruu1op 395 15 LRTI LRTI NNP cord-019051-gtruu1op 395 16 in in IN cord-019051-gtruu1op 395 17 2005 2005 CD cord-019051-gtruu1op 395 18 using use VBG cord-019051-gtruu1op 395 19 random random JJ cord-019051-gtruu1op 395 20 amplification amplification NN cord-019051-gtruu1op 395 21 methods method NNS cord-019051-gtruu1op 395 22 [ [ -LRB- cord-019051-gtruu1op 395 23 153 153 CD cord-019051-gtruu1op 395 24 ] ] -RRB- cord-019051-gtruu1op 395 25 . . . cord-019051-gtruu1op 396 1 HBoV hbov JJ cord-019051-gtruu1op 396 2 infection infection NN cord-019051-gtruu1op 396 3 is be VBZ cord-019051-gtruu1op 396 4 predominantly predominantly RB cord-019051-gtruu1op 396 5 associated associate VBN cord-019051-gtruu1op 396 6 with with IN cord-019051-gtruu1op 396 7 respiratory respiratory JJ cord-019051-gtruu1op 396 8 and/or and/or CC cord-019051-gtruu1op 396 9 gastrointestinal gastrointestinal JJ cord-019051-gtruu1op 396 10 symptoms symptom NNS cord-019051-gtruu1op 396 11 in in IN cord-019051-gtruu1op 396 12 children child NNS cord-019051-gtruu1op 396 13 at at IN cord-019051-gtruu1op 396 14 around around RB cord-019051-gtruu1op 396 15 2 2 CD cord-019051-gtruu1op 396 16 years year NNS cord-019051-gtruu1op 396 17 of of IN cord-019051-gtruu1op 396 18 age age NN cord-019051-gtruu1op 396 19 [ [ -LRB- cord-019051-gtruu1op 396 20 154 154 CD cord-019051-gtruu1op 396 21 ] ] -RRB- cord-019051-gtruu1op 396 22 . . . cord-019051-gtruu1op 397 1 Seroprevalence Seroprevalence NNP cord-019051-gtruu1op 397 2 reaches reach VBZ cord-019051-gtruu1op 397 3 95 95 CD cord-019051-gtruu1op 397 4 % % NN cord-019051-gtruu1op 397 5 in in IN cord-019051-gtruu1op 397 6 adults adult NNS cord-019051-gtruu1op 397 7 [ [ -LRB- cord-019051-gtruu1op 397 8 155 155 CD cord-019051-gtruu1op 397 9 ] ] -RRB- cord-019051-gtruu1op 397 10 . . . cord-019051-gtruu1op 398 1 However however RB cord-019051-gtruu1op 398 2 , , , cord-019051-gtruu1op 398 3 the the DT cord-019051-gtruu1op 398 4 role role NN cord-019051-gtruu1op 398 5 of of IN cord-019051-gtruu1op 398 6 HBoV HBoV NNP cord-019051-gtruu1op 398 7 in in IN cord-019051-gtruu1op 398 8 the the DT cord-019051-gtruu1op 398 9 pathogenesis pathogenesis NN cord-019051-gtruu1op 398 10 of of IN cord-019051-gtruu1op 398 11 human human JJ cord-019051-gtruu1op 398 12 respiratory respiratory JJ cord-019051-gtruu1op 398 13 disorders disorder NNS cord-019051-gtruu1op 398 14 is be VBZ cord-019051-gtruu1op 398 15 not not RB cord-019051-gtruu1op 398 16 yet yet RB cord-019051-gtruu1op 398 17 fully fully RB cord-019051-gtruu1op 398 18 understood understand VBN cord-019051-gtruu1op 398 19 -HBoV -HBoV : cord-019051-gtruu1op 398 20 infections infection NNS cord-019051-gtruu1op 398 21 are be VBP cord-019051-gtruu1op 398 22 frequently frequently RB cord-019051-gtruu1op 398 23 accompanied accompany VBN cord-019051-gtruu1op 398 24 by by IN cord-019051-gtruu1op 398 25 coinfections coinfection NNS cord-019051-gtruu1op 398 26 with with IN cord-019051-gtruu1op 398 27 other other JJ cord-019051-gtruu1op 398 28 viral viral JJ cord-019051-gtruu1op 398 29 and and CC cord-019051-gtruu1op 398 30 bacterial bacterial JJ cord-019051-gtruu1op 398 31 pathogens pathogen NNS cord-019051-gtruu1op 398 32 [ [ -LRB- cord-019051-gtruu1op 398 33 154 154 CD cord-019051-gtruu1op 398 34 ] ] -RRB- cord-019051-gtruu1op 398 35 . . . cord-019051-gtruu1op 399 1 HBoV HBoV NNP cord-019051-gtruu1op 399 2 is be VBZ cord-019051-gtruu1op 399 3 classified classify VBN cord-019051-gtruu1op 399 4 into into IN cord-019051-gtruu1op 399 5 the the DT cord-019051-gtruu1op 399 6 Parvoviridae Parvoviridae NNP cord-019051-gtruu1op 399 7 family family NN cord-019051-gtruu1op 399 8 , , , cord-019051-gtruu1op 399 9 subfamily subfamily NN cord-019051-gtruu1op 399 10 Parvovirinae Parvovirinae NNP cord-019051-gtruu1op 399 11 , , , cord-019051-gtruu1op 399 12 genus genus NN cord-019051-gtruu1op 399 13 Bocavirus Bocavirus NNP cord-019051-gtruu1op 399 14 . . . cord-019051-gtruu1op 400 1 As as IN cord-019051-gtruu1op 400 2 other other JJ cord-019051-gtruu1op 400 3 parvoviruses parvovirus NNS cord-019051-gtruu1op 400 4 , , , cord-019051-gtruu1op 400 5 HBoV HBoV NNP cord-019051-gtruu1op 400 6 virions virion NNS cord-019051-gtruu1op 400 7 are be VBP cord-019051-gtruu1op 400 8 icosahedral icosahedral JJ cord-019051-gtruu1op 400 9 nonenveloped nonenveloped JJ cord-019051-gtruu1op 400 10 particles particle NNS cord-019051-gtruu1op 400 11 with with IN cord-019051-gtruu1op 400 12 a a DT cord-019051-gtruu1op 400 13 diameter diameter NN cord-019051-gtruu1op 400 14 of of IN cord-019051-gtruu1op 400 15 21 21 CD cord-019051-gtruu1op 400 16 - - SYM cord-019051-gtruu1op 400 17 25 25 CD cord-019051-gtruu1op 400 18 nm nm NN cord-019051-gtruu1op 400 19 [ [ -LRB- cord-019051-gtruu1op 400 20 154 154 CD cord-019051-gtruu1op 400 21 ] ] -RRB- cord-019051-gtruu1op 400 22 . . . cord-019051-gtruu1op 401 1 The the DT cord-019051-gtruu1op 401 2 HBoV HBoV NNP cord-019051-gtruu1op 401 3 genome genome NN cord-019051-gtruu1op 401 4 ( ( -LRB- cord-019051-gtruu1op 401 5 a a DT cord-019051-gtruu1op 401 6 linear linear JJ cord-019051-gtruu1op 401 7 single single RB cord-019051-gtruu1op 401 8 - - HYPH cord-019051-gtruu1op 401 9 stranded strand VBN cord-019051-gtruu1op 401 10 DNA dna NN cord-019051-gtruu1op 401 11 that that WDT cord-019051-gtruu1op 401 12 encompasses encompass VBZ cord-019051-gtruu1op 401 13 approximately approximately RB cord-019051-gtruu1op 401 14 5.2 5.2 CD cord-019051-gtruu1op 401 15 kb kb NNS cord-019051-gtruu1op 401 16 ) ) -RRB- cord-019051-gtruu1op 401 17 is be VBZ cord-019051-gtruu1op 401 18 organized organize VBN cord-019051-gtruu1op 401 19 like like IN cord-019051-gtruu1op 401 20 that that DT cord-019051-gtruu1op 401 21 of of IN cord-019051-gtruu1op 401 22 other other JJ cord-019051-gtruu1op 401 23 parvoviruses parvovirus NNS cord-019051-gtruu1op 401 24 : : : cord-019051-gtruu1op 401 25 conserved conserve VBN cord-019051-gtruu1op 401 26 genes gene NNS cord-019051-gtruu1op 401 27 encoding encode VBG cord-019051-gtruu1op 401 28 for for IN cord-019051-gtruu1op 401 29 the the DT cord-019051-gtruu1op 401 30 two two CD cord-019051-gtruu1op 401 31 non non JJ cord-019051-gtruu1op 401 32 - - JJ cord-019051-gtruu1op 401 33 structural structural JJ cord-019051-gtruu1op 401 34 proteins protein NNS cord-019051-gtruu1op 401 35 are be VBP cord-019051-gtruu1op 401 36 located locate VBN cord-019051-gtruu1op 401 37 in in IN cord-019051-gtruu1op 401 38 the the DT cord-019051-gtruu1op 401 39 5 5 CD cord-019051-gtruu1op 401 40 ' ' '' cord-019051-gtruu1op 401 41 region region NN cord-019051-gtruu1op 401 42 and and CC cord-019051-gtruu1op 401 43 genes gene NNS cord-019051-gtruu1op 401 44 for for IN cord-019051-gtruu1op 401 45 two two CD cord-019051-gtruu1op 401 46 structural structural JJ cord-019051-gtruu1op 401 47 proteins protein NNS cord-019051-gtruu1op 401 48 are be VBP cord-019051-gtruu1op 401 49 located locate VBN cord-019051-gtruu1op 401 50 in in IN cord-019051-gtruu1op 401 51 the the DT cord-019051-gtruu1op 401 52 3 3 CD cord-019051-gtruu1op 401 53 ' ' '' cord-019051-gtruu1op 401 54 region region NN cord-019051-gtruu1op 401 55 of of IN cord-019051-gtruu1op 401 56 the the DT cord-019051-gtruu1op 401 57 genome genome NN cord-019051-gtruu1op 401 58 [ [ -LRB- cord-019051-gtruu1op 401 59 156 156 CD cord-019051-gtruu1op 401 60 ] ] -RRB- cord-019051-gtruu1op 401 61 . . . cord-019051-gtruu1op 402 1 The the DT cord-019051-gtruu1op 402 2 structural structural JJ cord-019051-gtruu1op 402 3 proteins protein NNS cord-019051-gtruu1op 402 4 VP1 vp1 NN cord-019051-gtruu1op 402 5 and and CC cord-019051-gtruu1op 402 6 VP2 VP2 NNP cord-019051-gtruu1op 402 7 are be VBP cord-019051-gtruu1op 402 8 identical identical JJ cord-019051-gtruu1op 402 9 in in IN cord-019051-gtruu1op 402 10 sequence sequence NN cord-019051-gtruu1op 402 11 but but CC cord-019051-gtruu1op 402 12 differ differ VBP cord-019051-gtruu1op 402 13 in in IN cord-019051-gtruu1op 402 14 an an DT cord-019051-gtruu1op 402 15 N n CD cord-019051-gtruu1op 402 16 - - HYPH cord-019051-gtruu1op 402 17 terminal terminal NN cord-019051-gtruu1op 402 18 extension extension NN cord-019051-gtruu1op 402 19 that that WDT cord-019051-gtruu1op 402 20 is be VBZ cord-019051-gtruu1op 402 21 only only RB cord-019051-gtruu1op 402 22 present present JJ cord-019051-gtruu1op 402 23 in in IN cord-019051-gtruu1op 402 24 VP1 VP1 NNP cord-019051-gtruu1op 402 25 ( ( -LRB- cord-019051-gtruu1op 402 26 VP1 VP1 NNP cord-019051-gtruu1op 402 27 unique unique JJ cord-019051-gtruu1op 402 28 region region NN cord-019051-gtruu1op 402 29 , , , cord-019051-gtruu1op 402 30 VP1u VP1u NNP cord-019051-gtruu1op 402 31 ) ) -RRB- cord-019051-gtruu1op 402 32 and and CC cord-019051-gtruu1op 402 33 possesses possess VBZ cord-019051-gtruu1op 402 34 a a DT cord-019051-gtruu1op 402 35 phospholipase phospholipase NN cord-019051-gtruu1op 402 36 A2-like a2-like IN cord-019051-gtruu1op 402 37 activity activity NN cord-019051-gtruu1op 402 38 ( ( -LRB- cord-019051-gtruu1op 402 39 PLA2 PLA2 NNP cord-019051-gtruu1op 402 40 ) ) -RRB- cord-019051-gtruu1op 402 41 [ [ -LRB- cord-019051-gtruu1op 402 42 157 157 CD cord-019051-gtruu1op 402 43 ] ] -RRB- cord-019051-gtruu1op 402 44 . . . cord-019051-gtruu1op 403 1 The the DT cord-019051-gtruu1op 403 2 functions function NNS cord-019051-gtruu1op 403 3 of of IN cord-019051-gtruu1op 403 4 the the DT cord-019051-gtruu1op 403 5 two two CD cord-019051-gtruu1op 403 6 nonstructural nonstructural JJ cord-019051-gtruu1op 403 7 proteins protein NNS cord-019051-gtruu1op 403 8 NS1 NS1 NNS cord-019051-gtruu1op 403 9 and and CC cord-019051-gtruu1op 403 10 NP1 np1 NN cord-019051-gtruu1op 403 11 of of IN cord-019051-gtruu1op 403 12 HBoV HBoV NNP cord-019051-gtruu1op 403 13 are be VBP cord-019051-gtruu1op 403 14 not not RB cord-019051-gtruu1op 403 15 known know VBN cord-019051-gtruu1op 403 16 ; ; : cord-019051-gtruu1op 403 17 however however RB cord-019051-gtruu1op 403 18 , , , cord-019051-gtruu1op 403 19 regulatory regulatory JJ cord-019051-gtruu1op 403 20 functions function NNS cord-019051-gtruu1op 403 21 of of IN cord-019051-gtruu1op 403 22 NS1 NS1 NNS cord-019051-gtruu1op 403 23 of of IN cord-019051-gtruu1op 403 24 other other JJ cord-019051-gtruu1op 403 25 parvoviruses parvovirus NNS cord-019051-gtruu1op 403 26 have have VBP cord-019051-gtruu1op 403 27 been be VBN cord-019051-gtruu1op 403 28 described describe VBN cord-019051-gtruu1op 403 29 [ [ -LRB- cord-019051-gtruu1op 403 30 154 154 CD cord-019051-gtruu1op 403 31 ] ] -RRB- cord-019051-gtruu1op 403 32 . . . cord-019051-gtruu1op 404 1 HBoV HBoV NNP cord-019051-gtruu1op 404 2 has have VBZ cord-019051-gtruu1op 404 3 been be VBN cord-019051-gtruu1op 404 4 detected detect VBN cord-019051-gtruu1op 404 5 in in IN cord-019051-gtruu1op 404 6 children child NNS cord-019051-gtruu1op 404 7 with with IN cord-019051-gtruu1op 404 8 respiratory respiratory JJ cord-019051-gtruu1op 404 9 disease disease NN cord-019051-gtruu1op 404 10 . . . cord-019051-gtruu1op 405 1 The the DT cord-019051-gtruu1op 405 2 range range NN cord-019051-gtruu1op 405 3 of of IN cord-019051-gtruu1op 405 4 clinical clinical JJ cord-019051-gtruu1op 405 5 manifestations manifestation NNS cord-019051-gtruu1op 405 6 is be VBZ cord-019051-gtruu1op 405 7 broad broad JJ cord-019051-gtruu1op 405 8 . . . cord-019051-gtruu1op 406 1 Diseases disease NNS cord-019051-gtruu1op 406 2 of of IN cord-019051-gtruu1op 406 3 the the DT cord-019051-gtruu1op 406 4 upper upper JJ cord-019051-gtruu1op 406 5 ( ( -LRB- cord-019051-gtruu1op 406 6 rhinitis rhinitis NN cord-019051-gtruu1op 406 7 or or CC cord-019051-gtruu1op 406 8 coughing cough VBG cord-019051-gtruu1op 406 9 ) ) -RRB- cord-019051-gtruu1op 406 10 and and CC cord-019051-gtruu1op 406 11 the the DT cord-019051-gtruu1op 406 12 lower low JJR cord-019051-gtruu1op 406 13 respiratory respiratory JJ cord-019051-gtruu1op 406 14 tract tract NN cord-019051-gtruu1op 406 15 ( ( -LRB- cord-019051-gtruu1op 406 16 including include VBG cord-019051-gtruu1op 406 17 pneumonia pneumonia NN cord-019051-gtruu1op 406 18 , , , cord-019051-gtruu1op 406 19 bronchiolitis bronchiolitis NN cord-019051-gtruu1op 406 20 and and CC cord-019051-gtruu1op 406 21 wheezing wheezing NN cord-019051-gtruu1op 406 22 ) ) -RRB- cord-019051-gtruu1op 406 23 or or CC cord-019051-gtruu1op 406 24 even even RB cord-019051-gtruu1op 406 25 the the DT cord-019051-gtruu1op 406 26 gastrointestinal gastrointestinal JJ cord-019051-gtruu1op 406 27 disease disease NN cord-019051-gtruu1op 406 28 have have VBP cord-019051-gtruu1op 406 29 been be VBN cord-019051-gtruu1op 406 30 described describe VBN cord-019051-gtruu1op 406 31 ( ( -LRB- cord-019051-gtruu1op 406 32 reviewed review VBN cord-019051-gtruu1op 406 33 in in IN cord-019051-gtruu1op 406 34 [ [ -LRB- cord-019051-gtruu1op 406 35 154 154 CD cord-019051-gtruu1op 406 36 ] ] -RRB- cord-019051-gtruu1op 406 37 ) ) -RRB- cord-019051-gtruu1op 406 38 . . . cord-019051-gtruu1op 407 1 Other other JJ cord-019051-gtruu1op 407 2 symptoms symptom NNS cord-019051-gtruu1op 407 3 include include VBP cord-019051-gtruu1op 407 4 fever fever NN cord-019051-gtruu1op 407 5 or or CC cord-019051-gtruu1op 407 6 rashes rash NNS cord-019051-gtruu1op 407 7 [ [ -LRB- cord-019051-gtruu1op 407 8 158 158 CD cord-019051-gtruu1op 407 9 ] ] -RRB- cord-019051-gtruu1op 407 10 . . . cord-019051-gtruu1op 408 1 However however RB cord-019051-gtruu1op 408 2 , , , cord-019051-gtruu1op 408 3 HBoV HBoV NNP cord-019051-gtruu1op 408 4 infections infection NNS cord-019051-gtruu1op 408 5 are be VBP cord-019051-gtruu1op 408 6 linked link VBN cord-019051-gtruu1op 408 7 frequently frequently RB cord-019051-gtruu1op 408 8 with with IN cord-019051-gtruu1op 408 9 coinfections coinfection NNS cord-019051-gtruu1op 408 10 with with IN cord-019051-gtruu1op 408 11 viral viral JJ cord-019051-gtruu1op 408 12 and and CC cord-019051-gtruu1op 408 13 bacterial bacterial JJ cord-019051-gtruu1op 408 14 pathogens pathogen NNS cord-019051-gtruu1op 408 15 in in IN cord-019051-gtruu1op 408 16 up up IN cord-019051-gtruu1op 408 17 to to IN cord-019051-gtruu1op 408 18 approximately approximately RB cord-019051-gtruu1op 408 19 69 69 CD cord-019051-gtruu1op 408 20 % % NN cord-019051-gtruu1op 408 21 of of IN cord-019051-gtruu1op 408 22 HBoV HBoV NNP cord-019051-gtruu1op 408 23 DNA dna NN cord-019051-gtruu1op 408 24 - - HYPH cord-019051-gtruu1op 408 25 positive positive JJ cord-019051-gtruu1op 408 26 individuals individual NNS cord-019051-gtruu1op 408 27 [ [ -LRB- cord-019051-gtruu1op 408 28 159 159 CD cord-019051-gtruu1op 408 29 ] ] -RRB- cord-019051-gtruu1op 408 30 which which WDT cord-019051-gtruu1op 408 31 makes make VBZ cord-019051-gtruu1op 408 32 it -PRON- PRP cord-019051-gtruu1op 408 33 rather rather RB cord-019051-gtruu1op 408 34 difficult difficult JJ cord-019051-gtruu1op 408 35 to to TO cord-019051-gtruu1op 408 36 distinguish distinguish VB cord-019051-gtruu1op 408 37 between between IN cord-019051-gtruu1op 408 38 symptoms symptom NNS cord-019051-gtruu1op 408 39 that that WDT cord-019051-gtruu1op 408 40 have have VBP cord-019051-gtruu1op 408 41 been be VBN cord-019051-gtruu1op 408 42 caused cause VBN cord-019051-gtruu1op 408 43 by by IN cord-019051-gtruu1op 408 44 HBoV HBoV NNP cord-019051-gtruu1op 408 45 or or CC cord-019051-gtruu1op 408 46 by by IN cord-019051-gtruu1op 408 47 other other JJ cord-019051-gtruu1op 408 48 pathogens pathogen NNS cord-019051-gtruu1op 408 49 . . . cord-019051-gtruu1op 409 1 The the DT cord-019051-gtruu1op 409 2 role role NN cord-019051-gtruu1op 409 3 of of IN cord-019051-gtruu1op 409 4 vertical vertical JJ cord-019051-gtruu1op 409 5 transmission transmission NN cord-019051-gtruu1op 409 6 , , , cord-019051-gtruu1op 409 7 seen see VBN cord-019051-gtruu1op 409 8 with with IN cord-019051-gtruu1op 409 9 other other JJ cord-019051-gtruu1op 409 10 parvoviruses parvovirus NNS cord-019051-gtruu1op 409 11 , , , cord-019051-gtruu1op 409 12 is be VBZ cord-019051-gtruu1op 409 13 not not RB cord-019051-gtruu1op 409 14 known know VBN cord-019051-gtruu1op 409 15 . . . cord-019051-gtruu1op 410 1 Antibodies antibody NNS cord-019051-gtruu1op 410 2 against against IN cord-019051-gtruu1op 410 3 the the DT cord-019051-gtruu1op 410 4 viral viral JJ cord-019051-gtruu1op 410 5 structural structural JJ cord-019051-gtruu1op 410 6 protein protein NN cord-019051-gtruu1op 410 7 VP1 VP1 NNP cord-019051-gtruu1op 410 8 have have VBP cord-019051-gtruu1op 410 9 been be VBN cord-019051-gtruu1op 410 10 detected detect VBN cord-019051-gtruu1op 410 11 in in IN cord-019051-gtruu1op 410 12 approximately approximately RB cord-019051-gtruu1op 410 13 95 95 CD cord-019051-gtruu1op 410 14 % % NN cord-019051-gtruu1op 410 15 of of IN cord-019051-gtruu1op 410 16 children child NNS cord-019051-gtruu1op 410 17 older old JJR cord-019051-gtruu1op 410 18 than than IN cord-019051-gtruu1op 410 19 2 2 CD cord-019051-gtruu1op 410 20 years year NNS cord-019051-gtruu1op 410 21 and and CC cord-019051-gtruu1op 410 22 adults adult NNS cord-019051-gtruu1op 410 23 [ [ -LRB- cord-019051-gtruu1op 410 24 155 155 CD cord-019051-gtruu1op 410 25 ] ] -RRB- cord-019051-gtruu1op 410 26 . . . cord-019051-gtruu1op 411 1 In in IN cord-019051-gtruu1op 411 2 addition addition NN cord-019051-gtruu1op 411 3 , , , cord-019051-gtruu1op 411 4 IgG1 igg1 NN cord-019051-gtruu1op 411 5 subclass subclass VBP cord-019051-gtruu1op 411 6 antibodies antibody NNS cord-019051-gtruu1op 411 7 against against IN cord-019051-gtruu1op 411 8 HBOV HBOV NNP cord-019051-gtruu1op 411 9 VP2-virus VP2-virus NNP cord-019051-gtruu1op 411 10 - - HYPH cord-019051-gtruu1op 411 11 like like JJ cord-019051-gtruu1op 411 12 particles particle NNS cord-019051-gtruu1op 411 13 ( ( -LRB- cord-019051-gtruu1op 411 14 VLP VLP NNP cord-019051-gtruu1op 411 15 ) ) -RRB- cord-019051-gtruu1op 411 16 were be VBD cord-019051-gtruu1op 411 17 detected detect VBN cord-019051-gtruu1op 411 18 in in IN cord-019051-gtruu1op 411 19 approximately approximately RB cord-019051-gtruu1op 411 20 98 98 CD cord-019051-gtruu1op 411 21 % % NN cord-019051-gtruu1op 411 22 of of IN cord-019051-gtruu1op 411 23 samples sample NNS cord-019051-gtruu1op 411 24 that that WDT cord-019051-gtruu1op 411 25 were be VBD cord-019051-gtruu1op 411 26 obtained obtain VBN cord-019051-gtruu1op 411 27 from from IN cord-019051-gtruu1op 411 28 healthy healthy JJ cord-019051-gtruu1op 411 29 adult adult NN cord-019051-gtruu1op 411 30 blood blood NN cord-019051-gtruu1op 411 31 donors donor NNS cord-019051-gtruu1op 411 32 [ [ -LRB- cord-019051-gtruu1op 411 33 154 154 CD cord-019051-gtruu1op 411 34 ] ] -RRB- cord-019051-gtruu1op 411 35 . . . cord-019051-gtruu1op 412 1 The the DT cord-019051-gtruu1op 412 2 same same JJ cord-019051-gtruu1op 412 3 authors author NNS cord-019051-gtruu1op 412 4 found find VBD cord-019051-gtruu1op 412 5 IgM IgM NNP cord-019051-gtruu1op 412 6 antibodies antibody NNS cord-019051-gtruu1op 412 7 in in IN cord-019051-gtruu1op 412 8 41.7 41.7 CD cord-019051-gtruu1op 412 9 % % NN cord-019051-gtruu1op 412 10 of of IN cord-019051-gtruu1op 412 11 sera sera NNP cord-019051-gtruu1op 412 12 from from IN cord-019051-gtruu1op 412 13 HBoV HBoV NNP cord-019051-gtruu1op 412 14 DNA dna NN cord-019051-gtruu1op 412 15 - - HYPH cord-019051-gtruu1op 412 16 positive positive JJ cord-019051-gtruu1op 412 17 children child NNS cord-019051-gtruu1op 412 18 but but CC cord-019051-gtruu1op 412 19 not not RB cord-019051-gtruu1op 412 20 in in IN cord-019051-gtruu1op 412 21 samples sample NNS cord-019051-gtruu1op 412 22 from from IN cord-019051-gtruu1op 412 23 DNA dna NN cord-019051-gtruu1op 412 24 - - HYPH cord-019051-gtruu1op 412 25 negative negative JJ cord-019051-gtruu1op 412 26 children child NNS cord-019051-gtruu1op 412 27 . . . cord-019051-gtruu1op 413 1 Cellular cellular JJ cord-019051-gtruu1op 413 2 immunity immunity NN cord-019051-gtruu1op 413 3 also also RB cord-019051-gtruu1op 413 4 plays play VBZ cord-019051-gtruu1op 413 5 a a DT cord-019051-gtruu1op 413 6 role role NN cord-019051-gtruu1op 413 7 in in IN cord-019051-gtruu1op 413 8 HBoV HBoV NNP cord-019051-gtruu1op 413 9 infections infection NNS cord-019051-gtruu1op 413 10 and and CC cord-019051-gtruu1op 413 11 frequent frequent JJ cord-019051-gtruu1op 413 12 CD4 CD4 NNP cord-019051-gtruu1op 413 13 + + CC cord-019051-gtruu1op 413 14 T t NN cord-019051-gtruu1op 413 15 helper helper NN cord-019051-gtruu1op 413 16 cell cell NN cord-019051-gtruu1op 413 17 reactions reaction NNS cord-019051-gtruu1op 413 18 have have VBP cord-019051-gtruu1op 413 19 been be VBN cord-019051-gtruu1op 413 20 observed observe VBN cord-019051-gtruu1op 413 21 against against IN cord-019051-gtruu1op 413 22 HBoV HBoV NNP cord-019051-gtruu1op 413 23 VLP VLP NNP cord-019051-gtruu1op 413 24 [ [ -LRB- cord-019051-gtruu1op 413 25 160 160 CD cord-019051-gtruu1op 413 26 ] ] -RRB- cord-019051-gtruu1op 413 27 . . . cord-019051-gtruu1op 414 1 Many many JJ cord-019051-gtruu1op 414 2 epidemiological epidemiological JJ cord-019051-gtruu1op 414 3 aspects aspect NNS cord-019051-gtruu1op 414 4 have have VBP cord-019051-gtruu1op 414 5 been be VBN cord-019051-gtruu1op 414 6 discussed discuss VBN cord-019051-gtruu1op 414 7 above above RB cord-019051-gtruu1op 414 8 . . . cord-019051-gtruu1op 415 1 However however RB cord-019051-gtruu1op 415 2 , , , cord-019051-gtruu1op 415 3 it -PRON- PRP cord-019051-gtruu1op 415 4 is be VBZ cord-019051-gtruu1op 415 5 noteworthy noteworthy JJ cord-019051-gtruu1op 415 6 that that IN cord-019051-gtruu1op 415 7 the the DT cord-019051-gtruu1op 415 8 majority majority NN cord-019051-gtruu1op 415 9 of of IN cord-019051-gtruu1op 415 10 the the DT cord-019051-gtruu1op 415 11 analyses analysis NNS cord-019051-gtruu1op 415 12 have have VBP cord-019051-gtruu1op 415 13 been be VBN cord-019051-gtruu1op 415 14 performed perform VBN cord-019051-gtruu1op 415 15 in in IN cord-019051-gtruu1op 415 16 symptomatic symptomatic JJ cord-019051-gtruu1op 415 17 individuals individual NNS cord-019051-gtruu1op 415 18 and and CC cord-019051-gtruu1op 415 19 more more JJR cord-019051-gtruu1op 415 20 data datum NNS cord-019051-gtruu1op 415 21 from from IN cord-019051-gtruu1op 415 22 asymptomatic asymptomatic JJ cord-019051-gtruu1op 415 23 healthy healthy JJ cord-019051-gtruu1op 415 24 chil chil NNS cord-019051-gtruu1op 415 25 - - HYPH cord-019051-gtruu1op 415 26 dren dren NNS cord-019051-gtruu1op 415 27 and and CC cord-019051-gtruu1op 415 28 adults adult NNS cord-019051-gtruu1op 415 29 would would MD cord-019051-gtruu1op 415 30 add add VB cord-019051-gtruu1op 415 31 to to IN cord-019051-gtruu1op 415 32 the the DT cord-019051-gtruu1op 415 33 understanding understanding NN cord-019051-gtruu1op 415 34 of of IN cord-019051-gtruu1op 415 35 the the DT cord-019051-gtruu1op 415 36 HBoV HBoV NNP cord-019051-gtruu1op 415 37 epidemiology epidemiology NN cord-019051-gtruu1op 415 38 . . . cord-019051-gtruu1op 416 1 Diagnosis diagnosis NN cord-019051-gtruu1op 416 2 of of IN cord-019051-gtruu1op 416 3 HBoV HBoV NNP cord-019051-gtruu1op 416 4 infection infection NN cord-019051-gtruu1op 416 5 is be VBZ cord-019051-gtruu1op 416 6 mainly mainly RB cord-019051-gtruu1op 416 7 done do VBN cord-019051-gtruu1op 416 8 by by IN cord-019051-gtruu1op 416 9 PCR PCR NNP cord-019051-gtruu1op 416 10 amplification amplification NN cord-019051-gtruu1op 416 11 of of IN cord-019051-gtruu1op 416 12 viral viral JJ cord-019051-gtruu1op 416 13 DNA dna NN cord-019051-gtruu1op 416 14 or or CC cord-019051-gtruu1op 416 15 the the DT cord-019051-gtruu1op 416 16 detection detection NN cord-019051-gtruu1op 416 17 of of IN cord-019051-gtruu1op 416 18 anti anti JJ cord-019051-gtruu1op 416 19 - - JJ cord-019051-gtruu1op 416 20 HBoV hbov JJ cord-019051-gtruu1op 416 21 antibodies antibody NNS cord-019051-gtruu1op 416 22 by by IN cord-019051-gtruu1op 416 23 ELISA ELISA NNP cord-019051-gtruu1op 416 24 [ [ -LRB- cord-019051-gtruu1op 416 25 154 154 CD cord-019051-gtruu1op 416 26 , , , cord-019051-gtruu1op 416 27 161 161 CD cord-019051-gtruu1op 416 28 ] ] -RRB- cord-019051-gtruu1op 416 29 . . . cord-019051-gtruu1op 417 1 At at IN cord-019051-gtruu1op 417 2 present present NN cord-019051-gtruu1op 417 3 , , , cord-019051-gtruu1op 417 4 no no DT cord-019051-gtruu1op 417 5 specific specific JJ cord-019051-gtruu1op 417 6 treatment treatment NN cord-019051-gtruu1op 417 7 of of IN cord-019051-gtruu1op 417 8 HBoV HBoV NNP cord-019051-gtruu1op 417 9 infections infection NNS cord-019051-gtruu1op 417 10 is be VBZ cord-019051-gtruu1op 417 11 available available JJ cord-019051-gtruu1op 417 12 . . . cord-019051-gtruu1op 418 1 Coronaviruses coronaviruse NNS cord-019051-gtruu1op 418 2 are be VBP cord-019051-gtruu1op 418 3 known know VBN cord-019051-gtruu1op 418 4 to to TO cord-019051-gtruu1op 418 5 cause cause VB cord-019051-gtruu1op 418 6 a a DT cord-019051-gtruu1op 418 7 variety variety NN cord-019051-gtruu1op 418 8 of of IN cord-019051-gtruu1op 418 9 diseases disease NNS cord-019051-gtruu1op 418 10 in in IN cord-019051-gtruu1op 418 11 animals animal NNS cord-019051-gtruu1op 418 12 [ [ -LRB- cord-019051-gtruu1op 418 13 161 161 CD cord-019051-gtruu1op 418 14 ] ] -RRB- cord-019051-gtruu1op 418 15 . . . cord-019051-gtruu1op 419 1 Human human JJ cord-019051-gtruu1op 419 2 coronaviruses coronaviruse NNS cord-019051-gtruu1op 419 3 are be VBP cord-019051-gtruu1op 419 4 mainly mainly RB cord-019051-gtruu1op 419 5 associated associate VBN cord-019051-gtruu1op 419 6 with with IN cord-019051-gtruu1op 419 7 respiratory respiratory JJ cord-019051-gtruu1op 419 8 disorders disorder NNS cord-019051-gtruu1op 419 9 ; ; : cord-019051-gtruu1op 419 10 some some DT cord-019051-gtruu1op 419 11 may may MD cord-019051-gtruu1op 419 12 cause cause VB cord-019051-gtruu1op 419 13 enteric enteric JJ cord-019051-gtruu1op 419 14 infections infection NNS cord-019051-gtruu1op 419 15 [ [ -LRB- cord-019051-gtruu1op 419 16 162 162 CD cord-019051-gtruu1op 419 17 ] ] -RRB- cord-019051-gtruu1op 419 18 . . . cord-019051-gtruu1op 420 1 The the DT cord-019051-gtruu1op 420 2 human human JJ cord-019051-gtruu1op 420 3 coronaviruses coronaviruse NNS cord-019051-gtruu1op 420 4 HCoV-229E HCoV-229E NNP cord-019051-gtruu1op 420 5 and and CC cord-019051-gtruu1op 420 6 HCoV HCoV NNP cord-019051-gtruu1op 420 7 - - HYPH cord-019051-gtruu1op 420 8 OC43 OC43 NNP cord-019051-gtruu1op 420 9 were be VBD cord-019051-gtruu1op 420 10 identified identify VBN cord-019051-gtruu1op 420 11 in in IN cord-019051-gtruu1op 420 12 the the DT cord-019051-gtruu1op 420 13 1960s 1960 NNS cord-019051-gtruu1op 420 14 [ [ -LRB- cord-019051-gtruu1op 420 15 163 163 CD cord-019051-gtruu1op 420 16 ] ] -RRB- cord-019051-gtruu1op 420 17 [ [ -LRB- cord-019051-gtruu1op 420 18 164 164 CD cord-019051-gtruu1op 420 19 ] ] -RRB- cord-019051-gtruu1op 420 20 [ [ -LRB- cord-019051-gtruu1op 420 21 165 165 CD cord-019051-gtruu1op 420 22 ] ] -RRB- cord-019051-gtruu1op 420 23 . . . cord-019051-gtruu1op 421 1 A a DT cord-019051-gtruu1op 421 2 coronavirus coronavirus NN cord-019051-gtruu1op 421 3 causing cause VBG cord-019051-gtruu1op 421 4 a a DT cord-019051-gtruu1op 421 5 severe severe JJ cord-019051-gtruu1op 421 6 acute acute JJ cord-019051-gtruu1op 421 7 human human JJ cord-019051-gtruu1op 421 8 respiratory respiratory JJ cord-019051-gtruu1op 421 9 syndrome syndrome NN cord-019051-gtruu1op 421 10 ( ( -LRB- cord-019051-gtruu1op 421 11 SARS SARS NNP cord-019051-gtruu1op 421 12 ) ) -RRB- cord-019051-gtruu1op 421 13 , , , cord-019051-gtruu1op 421 14 the the DT cord-019051-gtruu1op 421 15 SARS SARS NNP cord-019051-gtruu1op 421 16 - - HYPH cord-019051-gtruu1op 421 17 CoV CoV NNP cord-019051-gtruu1op 421 18 , , , cord-019051-gtruu1op 421 19 was be VBD cord-019051-gtruu1op 421 20 first first RB cord-019051-gtruu1op 421 21 described describe VBN cord-019051-gtruu1op 421 22 in in IN cord-019051-gtruu1op 421 23 2003 2003 CD cord-019051-gtruu1op 421 24 [ [ -LRB- cord-019051-gtruu1op 421 25 166 166 CD cord-019051-gtruu1op 421 26 , , , cord-019051-gtruu1op 421 27 167 167 CD cord-019051-gtruu1op 421 28 ] ] -RRB- cord-019051-gtruu1op 421 29 and and CC cord-019051-gtruu1op 421 30 two two CD cord-019051-gtruu1op 421 31 additional additional JJ cord-019051-gtruu1op 421 32 human human JJ cord-019051-gtruu1op 421 33 coronaviruses coronaviruse NNS cord-019051-gtruu1op 421 34 , , , cord-019051-gtruu1op 421 35 HCoV HCoV NNP cord-019051-gtruu1op 421 36 - - HYPH cord-019051-gtruu1op 421 37 NL61 NL61 NNP cord-019051-gtruu1op 421 38 and and CC cord-019051-gtruu1op 421 39 HCoV HCoV NNP cord-019051-gtruu1op 421 40 - - HYPH cord-019051-gtruu1op 421 41 HKU1 HKU1 NNP cord-019051-gtruu1op 421 42 that that WDT cord-019051-gtruu1op 421 43 were be VBD cord-019051-gtruu1op 421 44 both both DT cord-019051-gtruu1op 421 45 linked link VBN cord-019051-gtruu1op 421 46 to to IN cord-019051-gtruu1op 421 47 respiratory respiratory JJ cord-019051-gtruu1op 421 48 disorders disorder NNS cord-019051-gtruu1op 421 49 have have VBP cord-019051-gtruu1op 421 50 been be VBN cord-019051-gtruu1op 421 51 identified identify VBN cord-019051-gtruu1op 421 52 recently recently RB cord-019051-gtruu1op 421 53 [ [ -LRB- cord-019051-gtruu1op 421 54 168 168 CD cord-019051-gtruu1op 421 55 , , , cord-019051-gtruu1op 421 56 169 169 CD cord-019051-gtruu1op 421 57 ] ] -RRB- cord-019051-gtruu1op 421 58 . . . cord-019051-gtruu1op 422 1 Because because IN cord-019051-gtruu1op 422 2 of of IN cord-019051-gtruu1op 422 3 the the DT cord-019051-gtruu1op 422 4 economic economic JJ cord-019051-gtruu1op 422 5 importance importance NN cord-019051-gtruu1op 422 6 of of IN cord-019051-gtruu1op 422 7 coronaviruses coronaviruse NNS cord-019051-gtruu1op 422 8 in in IN cord-019051-gtruu1op 422 9 veterinary veterinary JJ cord-019051-gtruu1op 422 10 medicine medicine NN cord-019051-gtruu1op 422 11 ( ( -LRB- cord-019051-gtruu1op 422 12 for for IN cord-019051-gtruu1op 422 13 instance instance NN cord-019051-gtruu1op 422 14 in in IN cord-019051-gtruu1op 422 15 swine swine NN cord-019051-gtruu1op 422 16 ) ) -RRB- cord-019051-gtruu1op 422 17 , , , cord-019051-gtruu1op 422 18 development development NN cord-019051-gtruu1op 422 19 of of IN cord-019051-gtruu1op 422 20 vaccines vaccine NNS cord-019051-gtruu1op 422 21 is be VBZ cord-019051-gtruu1op 422 22 more more RBR cord-019051-gtruu1op 422 23 advanced advanced JJ cord-019051-gtruu1op 422 24 in in IN cord-019051-gtruu1op 422 25 veterinary veterinary JJ cord-019051-gtruu1op 422 26 medicine medicine NN cord-019051-gtruu1op 422 27 than than IN cord-019051-gtruu1op 422 28 in in IN cord-019051-gtruu1op 422 29 human human JJ cord-019051-gtruu1op 422 30 medicine medicine NN cord-019051-gtruu1op 422 31 . . . cord-019051-gtruu1op 423 1 However however RB cord-019051-gtruu1op 423 2 , , , cord-019051-gtruu1op 423 3 with with IN cord-019051-gtruu1op 423 4 the the DT cord-019051-gtruu1op 423 5 appearance appearance NN cord-019051-gtruu1op 423 6 of of IN cord-019051-gtruu1op 423 7 the the DT cord-019051-gtruu1op 423 8 SARS SARS NNP cord-019051-gtruu1op 423 9 coronavirus coronavirus NN cord-019051-gtruu1op 423 10 , , , cord-019051-gtruu1op 423 11 human human JJ cord-019051-gtruu1op 423 12 coronaviruses coronaviruse NNS cord-019051-gtruu1op 423 13 gained gain VBD cord-019051-gtruu1op 423 14 a a DT cord-019051-gtruu1op 423 15 greater great JJR cord-019051-gtruu1op 423 16 share share NN cord-019051-gtruu1op 423 17 of of IN cord-019051-gtruu1op 423 18 interest interest NN cord-019051-gtruu1op 423 19 . . . cord-019051-gtruu1op 424 1 Coronaviruses coronaviruse NNS cord-019051-gtruu1op 424 2 belong belong VBP cord-019051-gtruu1op 424 3 to to IN cord-019051-gtruu1op 424 4 the the DT cord-019051-gtruu1op 424 5 order order NN cord-019051-gtruu1op 424 6 Nidovirales Nidovirales NNP cord-019051-gtruu1op 424 7 , , , cord-019051-gtruu1op 424 8 family family NN cord-019051-gtruu1op 424 9 Coronaviridae Coronaviridae NNP cord-019051-gtruu1op 424 10 , , , cord-019051-gtruu1op 425 1 genus genus NN cord-019051-gtruu1op 425 2 : : : cord-019051-gtruu1op 425 3 Coronavirus Coronavirus NNP cord-019051-gtruu1op 425 4 . . . cord-019051-gtruu1op 426 1 In in IN cord-019051-gtruu1op 426 2 addition addition NN cord-019051-gtruu1op 426 3 to to IN cord-019051-gtruu1op 426 4 the the DT cord-019051-gtruu1op 426 5 five five CD cord-019051-gtruu1op 426 6 human human JJ cord-019051-gtruu1op 426 7 coronaviruses coronaviruse NNS cord-019051-gtruu1op 426 8 ( ( -LRB- cord-019051-gtruu1op 426 9 HCoV-229E HCoV-229E NNP cord-019051-gtruu1op 426 10 , , , cord-019051-gtruu1op 426 11 HCoV HCoV NNP cord-019051-gtruu1op 426 12 - - HYPH cord-019051-gtruu1op 426 13 HKU1 HKU1 NNP cord-019051-gtruu1op 426 14 , , , cord-019051-gtruu1op 426 15 HCoV HCoV NNP cord-019051-gtruu1op 426 16 - - HYPH cord-019051-gtruu1op 426 17 NL NL NNP cord-019051-gtruu1op 426 18 63 63 CD cord-019051-gtruu1op 426 19 , , , cord-019051-gtruu1op 426 20 HCoV HCoV NNP cord-019051-gtruu1op 426 21 - - HYPH cord-019051-gtruu1op 426 22 OC43 OC43 NNP cord-019051-gtruu1op 426 23 and and CC cord-019051-gtruu1op 426 24 SARS SARS NNP cord-019051-gtruu1op 426 25 - - HYPH cord-019051-gtruu1op 426 26 CoV CoV NNP cord-019051-gtruu1op 426 27 ) ) -RRB- cord-019051-gtruu1op 426 28 , , , cord-019051-gtruu1op 426 29 a a DT cord-019051-gtruu1op 426 30 specific specific JJ cord-019051-gtruu1op 426 31 human human JJ cord-019051-gtruu1op 426 32 enteric enteric JJ cord-019051-gtruu1op 426 33 coronavirus coronavirus NN cord-019051-gtruu1op 426 34 has have VBZ cord-019051-gtruu1op 426 35 been be VBN cord-019051-gtruu1op 426 36 reported report VBN cord-019051-gtruu1op 426 37 [ [ -LRB- cord-019051-gtruu1op 426 38 170 170 CD cord-019051-gtruu1op 426 39 ] ] -RRB- cord-019051-gtruu1op 426 40 . . . cord-019051-gtruu1op 427 1 Coronaviruses coronaviruse NNS cord-019051-gtruu1op 427 2 have have VBP cord-019051-gtruu1op 427 3 been be VBN cord-019051-gtruu1op 427 4 assigned assign VBN cord-019051-gtruu1op 427 5 to to IN cord-019051-gtruu1op 427 6 three three CD cord-019051-gtruu1op 427 7 groups group NNS cord-019051-gtruu1op 427 8 based base VBN cord-019051-gtruu1op 427 9 on on IN cord-019051-gtruu1op 427 10 antigenic antigenic JJ cord-019051-gtruu1op 427 11 relationships relationship NNS cord-019051-gtruu1op 427 12 between between IN cord-019051-gtruu1op 427 13 species specie NNS cord-019051-gtruu1op 427 14 of of IN cord-019051-gtruu1op 427 15 different different JJ cord-019051-gtruu1op 427 16 groups group NNS cord-019051-gtruu1op 427 17 ( ( -LRB- cord-019051-gtruu1op 427 18 reviewed review VBN cord-019051-gtruu1op 427 19 in in IN cord-019051-gtruu1op 427 20 [ [ -LRB- cord-019051-gtruu1op 427 21 171 171 CD cord-019051-gtruu1op 427 22 ] ] -RRB- cord-019051-gtruu1op 427 23 ) ) -RRB- cord-019051-gtruu1op 427 24 . . . cord-019051-gtruu1op 428 1 HCoV-229E HCoV-229E NNP cord-019051-gtruu1op 428 2 and and CC cord-019051-gtruu1op 428 3 HCoV HCoV NNP cord-019051-gtruu1op 429 1 -NL63 -NL63 : cord-019051-gtruu1op 429 2 are be VBP cord-019051-gtruu1op 429 3 included include VBN cord-019051-gtruu1op 429 4 in in IN cord-019051-gtruu1op 429 5 group group NN cord-019051-gtruu1op 429 6 1 1 CD cord-019051-gtruu1op 429 7 , , , cord-019051-gtruu1op 429 8 HCoV HCoV NNP cord-019051-gtruu1op 429 9 - - HYPH cord-019051-gtruu1op 429 10 HKU1 HKU1 NNP cord-019051-gtruu1op 429 11 and and CC cord-019051-gtruu1op 429 12 HCoV HCoV NNP cord-019051-gtruu1op 429 13 - - HYPH cord-019051-gtruu1op 429 14 OC43 OC43 NNP cord-019051-gtruu1op 429 15 in in IN cord-019051-gtruu1op 429 16 group group NN cord-019051-gtruu1op 429 17 2 2 CD cord-019051-gtruu1op 429 18 and and CC cord-019051-gtruu1op 429 19 SARS SARS NNP cord-019051-gtruu1op 429 20 - - HYPH cord-019051-gtruu1op 429 21 CoV CoV NNP cord-019051-gtruu1op 429 22 represents represent VBZ cord-019051-gtruu1op 429 23 an an DT cord-019051-gtruu1op 429 24 early early JJ cord-019051-gtruu1op 429 25 split split NN cord-019051-gtruu1op 429 26 from from IN cord-019051-gtruu1op 429 27 group group NN cord-019051-gtruu1op 429 28 2 2 CD cord-019051-gtruu1op 429 29 [ [ -LRB- cord-019051-gtruu1op 429 30 172 172 CD cord-019051-gtruu1op 429 31 ] ] -RRB- cord-019051-gtruu1op 429 32 . . . cord-019051-gtruu1op 430 1 Coronaviruses coronaviruse NNS cord-019051-gtruu1op 430 2 are be VBP cord-019051-gtruu1op 430 3 enveloped envelop VBN cord-019051-gtruu1op 430 4 viruses virus NNS cord-019051-gtruu1op 430 5 , , , cord-019051-gtruu1op 430 6 approximately approximately RB cord-019051-gtruu1op 430 7 120 120 CD cord-019051-gtruu1op 430 8 nm nm NN cord-019051-gtruu1op 430 9 in in IN cord-019051-gtruu1op 430 10 diameter diameter NN cord-019051-gtruu1op 430 11 with with IN cord-019051-gtruu1op 430 12 large large JJ cord-019051-gtruu1op 430 13 ( ( -LRB- cord-019051-gtruu1op 430 14 20 20 CD cord-019051-gtruu1op 430 15 nm nm NN cord-019051-gtruu1op 430 16 ) ) -RRB- cord-019051-gtruu1op 430 17 club club NN cord-019051-gtruu1op 430 18 - - HYPH cord-019051-gtruu1op 430 19 shaped shape VBN cord-019051-gtruu1op 430 20 surface surface NN cord-019051-gtruu1op 430 21 projections projection NNS cord-019051-gtruu1op 430 22 ( ( -LRB- cord-019051-gtruu1op 430 23 spike spike NN cord-019051-gtruu1op 430 24 protein protein NN cord-019051-gtruu1op 430 25 , , , cord-019051-gtruu1op 430 26 S S NNP cord-019051-gtruu1op 430 27 ) ) -RRB- cord-019051-gtruu1op 430 28 . . . cord-019051-gtruu1op 431 1 The the DT cord-019051-gtruu1op 431 2 structure structure NN cord-019051-gtruu1op 431 3 and and CC cord-019051-gtruu1op 431 4 function function NN cord-019051-gtruu1op 431 5 of of IN cord-019051-gtruu1op 431 6 the the DT cord-019051-gtruu1op 431 7 S S NNP cord-019051-gtruu1op 431 8 protein protein NN cord-019051-gtruu1op 431 9 have have VBP cord-019051-gtruu1op 431 10 been be VBN cord-019051-gtruu1op 431 11 reviewed review VBN cord-019051-gtruu1op 431 12 elsewhere elsewhere RB cord-019051-gtruu1op 431 13 [ [ -LRB- cord-019051-gtruu1op 431 14 173 173 CD cord-019051-gtruu1op 431 15 ] ] -RRB- cord-019051-gtruu1op 431 16 . . . cord-019051-gtruu1op 432 1 Apart apart RB cord-019051-gtruu1op 432 2 from from IN cord-019051-gtruu1op 432 3 S S NNP cord-019051-gtruu1op 432 4 , , , cord-019051-gtruu1op 432 5 coronaviruses coronaviruse NNS cord-019051-gtruu1op 432 6 have have VBP cord-019051-gtruu1op 432 7 a a DT cord-019051-gtruu1op 432 8 smaller small JJR cord-019051-gtruu1op 432 9 membrane membrane NN cord-019051-gtruu1op 432 10 protein protein NN cord-019051-gtruu1op 432 11 , , , cord-019051-gtruu1op 432 12 M M NNP cord-019051-gtruu1op 432 13 ( ( -LRB- cord-019051-gtruu1op 432 14 reviewed review VBN cord-019051-gtruu1op 432 15 in in IN cord-019051-gtruu1op 432 16 [ [ -LRB- cord-019051-gtruu1op 432 17 174 174 CD cord-019051-gtruu1op 432 18 ] ] -RRB- cord-019051-gtruu1op 432 19 ) ) -RRB- cord-019051-gtruu1op 432 20 . . . cord-019051-gtruu1op 433 1 In in IN cord-019051-gtruu1op 433 2 addition addition NN cord-019051-gtruu1op 433 3 , , , cord-019051-gtruu1op 433 4 coronaviruses coronaviruse NNS cord-019051-gtruu1op 433 5 have have VBP cord-019051-gtruu1op 433 6 a a DT cord-019051-gtruu1op 433 7 third third JJ cord-019051-gtruu1op 433 8 envelope envelope NN cord-019051-gtruu1op 433 9 protein protein NN cord-019051-gtruu1op 433 10 , , , cord-019051-gtruu1op 433 11 the the DT cord-019051-gtruu1op 433 12 very very RB cord-019051-gtruu1op 433 13 small small JJ cord-019051-gtruu1op 433 14 , , , cord-019051-gtruu1op 433 15 non non JJ cord-019051-gtruu1op 433 16 - - JJ cord-019051-gtruu1op 433 17 glycosylated glycosylated JJ cord-019051-gtruu1op 433 18 E e NN cord-019051-gtruu1op 433 19 protein protein NN cord-019051-gtruu1op 433 20 [ [ -LRB- cord-019051-gtruu1op 433 21 175 175 CD cord-019051-gtruu1op 433 22 ] ] -RRB- cord-019051-gtruu1op 433 23 . . . cord-019051-gtruu1op 434 1 E E NNP cord-019051-gtruu1op 434 2 and and CC cord-019051-gtruu1op 434 3 M M NNP cord-019051-gtruu1op 434 4 have have VBP cord-019051-gtruu1op 434 5 been be VBN cord-019051-gtruu1op 434 6 found find VBN cord-019051-gtruu1op 434 7 to to TO cord-019051-gtruu1op 434 8 be be VB cord-019051-gtruu1op 434 9 essential essential JJ cord-019051-gtruu1op 434 10 for for IN cord-019051-gtruu1op 434 11 virus virus NN cord-019051-gtruu1op 434 12 particle particle NN cord-019051-gtruu1op 434 13 formation formation NN cord-019051-gtruu1op 434 14 ( ( -LRB- cord-019051-gtruu1op 434 15 reviewed review VBN cord-019051-gtruu1op 434 16 in in IN cord-019051-gtruu1op 434 17 [ [ -LRB- cord-019051-gtruu1op 434 18 176 176 CD cord-019051-gtruu1op 434 19 ] ] -RRB- cord-019051-gtruu1op 434 20 ) ) -RRB- cord-019051-gtruu1op 434 21 . . . cord-019051-gtruu1op 435 1 Group group NN cord-019051-gtruu1op 435 2 2 2 CD cord-019051-gtruu1op 435 3 coronaviruses coronaviruse NNS cord-019051-gtruu1op 435 4 also also RB cord-019051-gtruu1op 435 5 have have VBP cord-019051-gtruu1op 435 6 an an DT cord-019051-gtruu1op 435 7 HE HE NNP cord-019051-gtruu1op 435 8 ( ( -LRB- cord-019051-gtruu1op 435 9 hemagglutinin hemagglutinin NN cord-019051-gtruu1op 435 10 esterase esterase NN cord-019051-gtruu1op 435 11 ) ) -RRB- cord-019051-gtruu1op 435 12 protein protein NN cord-019051-gtruu1op 435 13 that that WDT cord-019051-gtruu1op 435 14 forms form VBZ cord-019051-gtruu1op 435 15 a a DT cord-019051-gtruu1op 435 16 layer layer NN cord-019051-gtruu1op 435 17 of of IN cord-019051-gtruu1op 435 18 approximately approximately RB cord-019051-gtruu1op 435 19 7 7 CD cord-019051-gtruu1op 435 20 nm nm NN cord-019051-gtruu1op 435 21 [ [ -LRB- cord-019051-gtruu1op 435 22 175 175 CD cord-019051-gtruu1op 435 23 ] ] -RRB- cord-019051-gtruu1op 435 24 . . . cord-019051-gtruu1op 436 1 HE he PRP cord-019051-gtruu1op 436 2 is be VBZ cord-019051-gtruu1op 436 3 a a DT cord-019051-gtruu1op 436 4 neuraminic neuraminic JJ cord-019051-gtruu1op 436 5 acetylesterase acetylesterase NN cord-019051-gtruu1op 436 6 that that WDT cord-019051-gtruu1op 436 7 hydrolyses hydrolyse VBZ cord-019051-gtruu1op 436 8 the the DT cord-019051-gtruu1op 436 9 9-O 9-o CD cord-019051-gtruu1op 436 10 - - HYPH cord-019051-gtruu1op 436 11 acetylated acetylated JJ cord-019051-gtruu1op 436 12 sialic sialic NN cord-019051-gtruu1op 436 13 acid acid NN cord-019051-gtruu1op 436 14 on on IN cord-019051-gtruu1op 436 15 erythrocytes erythrocyte NNS cord-019051-gtruu1op 436 16 , , , cord-019051-gtruu1op 436 17 thus thus RB cord-019051-gtruu1op 436 18 potentially potentially RB cord-019051-gtruu1op 436 19 destroying destroy VBG cord-019051-gtruu1op 436 20 receptors receptor NNS cord-019051-gtruu1op 436 21 [ [ -LRB- cord-019051-gtruu1op 436 22 177 177 CD cord-019051-gtruu1op 436 23 ] ] -RRB- cord-019051-gtruu1op 436 24 . . . cord-019051-gtruu1op 437 1 Another another DT cord-019051-gtruu1op 437 2 coronavirus coronavirus NN cord-019051-gtruu1op 437 3 protein protein NN cord-019051-gtruu1op 437 4 , , , cord-019051-gtruu1op 437 5 N N NNP cord-019051-gtruu1op 437 6 , , , cord-019051-gtruu1op 437 7 is be VBZ cord-019051-gtruu1op 437 8 closely closely RB cord-019051-gtruu1op 437 9 linked link VBN cord-019051-gtruu1op 437 10 to to IN cord-019051-gtruu1op 437 11 the the DT cord-019051-gtruu1op 437 12 RNA RNA NNP cord-019051-gtruu1op 437 13 genome genome NN cord-019051-gtruu1op 437 14 ( ( -LRB- cord-019051-gtruu1op 437 15 and and CC cord-019051-gtruu1op 437 16 forms form VBZ cord-019051-gtruu1op 437 17 a a DT cord-019051-gtruu1op 437 18 ribonucleoprotein ribonucleoprotein NN cord-019051-gtruu1op 437 19 , , , cord-019051-gtruu1op 437 20 RNP RNP NNP cord-019051-gtruu1op 437 21 ) ) -RRB- cord-019051-gtruu1op 437 22 . . . cord-019051-gtruu1op 438 1 N N NNP cord-019051-gtruu1op 438 2 , , , cord-019051-gtruu1op 438 3 which which WDT cord-019051-gtruu1op 438 4 may may MD cord-019051-gtruu1op 438 5 have have VB cord-019051-gtruu1op 438 6 a a DT cord-019051-gtruu1op 438 7 functional functional JJ cord-019051-gtruu1op 438 8 role role NN cord-019051-gtruu1op 438 9 in in IN cord-019051-gtruu1op 438 10 replication replication NN cord-019051-gtruu1op 438 11 and and CC cord-019051-gtruu1op 438 12 transcription transcription NN cord-019051-gtruu1op 438 13 , , , cord-019051-gtruu1op 438 14 is be VBZ cord-019051-gtruu1op 438 15 phosphorylated phosphorylate VBN cord-019051-gtruu1op 438 16 ( ( -LRB- cord-019051-gtruu1op 438 17 reviewed review VBN cord-019051-gtruu1op 438 18 in in IN cord-019051-gtruu1op 438 19 [ [ -LRB- cord-019051-gtruu1op 438 20 178 178 CD cord-019051-gtruu1op 438 21 ] ] -RRB- cord-019051-gtruu1op 438 22 ) ) -RRB- cord-019051-gtruu1op 438 23 . . . cord-019051-gtruu1op 439 1 Coronaviruses coronaviruse NNS cord-019051-gtruu1op 439 2 have have VBP cord-019051-gtruu1op 439 3 positive positive JJ cord-019051-gtruu1op 439 4 - - HYPH cord-019051-gtruu1op 439 5 sense sense NN cord-019051-gtruu1op 439 6 single single JJ cord-019051-gtruu1op 439 7 - - HYPH cord-019051-gtruu1op 439 8 stranded strand VBN cord-019051-gtruu1op 439 9 RNA RNA NNP cord-019051-gtruu1op 439 10 genomes genome NNS cord-019051-gtruu1op 439 11 of of IN cord-019051-gtruu1op 439 12 about about RB cord-019051-gtruu1op 439 13 30 30 CD cord-019051-gtruu1op 439 14 kb kb NNS cord-019051-gtruu1op 439 15 . . . cord-019051-gtruu1op 440 1 The the DT cord-019051-gtruu1op 440 2 genome genome NN cord-019051-gtruu1op 440 3 is be VBZ cord-019051-gtruu1op 440 4 generally generally RB cord-019051-gtruu1op 440 5 organized organize VBN cord-019051-gtruu1op 440 6 in in IN cord-019051-gtruu1op 440 7 the the DT cord-019051-gtruu1op 440 8 following following JJ cord-019051-gtruu1op 440 9 manner manner NN cord-019051-gtruu1op 440 10 : : : cord-019051-gtruu1op 440 11 5'-UTR 5'-utr CD cord-019051-gtruu1op 440 12 - - HYPH cord-019051-gtruu1op 440 13 polymerase polymerase NN cord-019051-gtruu1op 440 14 gene gene NN cord-019051-gtruu1op 440 15 - - HYPH cord-019051-gtruu1op 440 16 structural structural JJ cord-019051-gtruu1op 440 17 protein protein NN cord-019051-gtruu1op 440 18 genes gene NNS cord-019051-gtruu1op 440 19 - - : cord-019051-gtruu1op 440 20 UTR3 UTR3 NNP cord-019051-gtruu1op 440 21 ' ' '' cord-019051-gtruu1op 440 22 where where WRB cord-019051-gtruu1op 440 23 the the DT cord-019051-gtruu1op 440 24 UTR UTR NNP cord-019051-gtruu1op 440 25 are be VBP cord-019051-gtruu1op 440 26 untranslated untranslated JJ cord-019051-gtruu1op 440 27 regions region NNS cord-019051-gtruu1op 440 28 each each DT cord-019051-gtruu1op 440 29 up up IN cord-019051-gtruu1op 440 30 to to TO cord-019051-gtruu1op 440 31 500 500 CD cord-019051-gtruu1op 440 32 nucleotides nucleotide NNS cord-019051-gtruu1op 440 33 . . . cord-019051-gtruu1op 441 1 The the DT cord-019051-gtruu1op 441 2 structural structural JJ cord-019051-gtruu1op 441 3 proteins protein NNS cord-019051-gtruu1op 441 4 are be VBP cord-019051-gtruu1op 441 5 encoded encode VBN cord-019051-gtruu1op 441 6 in in IN cord-019051-gtruu1op 441 7 the the DT cord-019051-gtruu1op 441 8 following following JJ cord-019051-gtruu1op 441 9 order order NN cord-019051-gtruu1op 441 10 : : : cord-019051-gtruu1op 441 11 HE he PRP cord-019051-gtruu1op 441 12 ( ( -LRB- cord-019051-gtruu1op 441 13 only only RB cord-019051-gtruu1op 441 14 group group NN cord-019051-gtruu1op 441 15 2 2 CD cord-019051-gtruu1op 441 16 coronaviruses coronaviruse NNS cord-019051-gtruu1op 441 17 ) ) -RRB- cord-019051-gtruu1op 442 1 -S -S . cord-019051-gtruu1op 443 1 -E -E : cord-019051-gtruu1op 444 1 -M -M . cord-019051-gtruu1op 445 1 -N -N NFP cord-019051-gtruu1op 445 2 [ [ -LRB- cord-019051-gtruu1op 445 3 171 171 CD cord-019051-gtruu1op 445 4 ] ] -RRB- cord-019051-gtruu1op 445 5 . . . cord-019051-gtruu1op 446 1 The the DT cord-019051-gtruu1op 446 2 infection infection NN cord-019051-gtruu1op 446 3 is be VBZ cord-019051-gtruu1op 446 4 initiated initiate VBN cord-019051-gtruu1op 446 5 by by IN cord-019051-gtruu1op 446 6 binding bind VBG cord-019051-gtruu1op 446 7 of of IN cord-019051-gtruu1op 446 8 the the DT cord-019051-gtruu1op 446 9 S S NNP cord-019051-gtruu1op 446 10 protein protein NN cord-019051-gtruu1op 446 11 to to IN cord-019051-gtruu1op 446 12 the the DT cord-019051-gtruu1op 446 13 cell cell NN cord-019051-gtruu1op 446 14 receptor receptor NN cord-019051-gtruu1op 446 15 [ [ -LRB- cord-019051-gtruu1op 446 16 179 179 CD cord-019051-gtruu1op 446 17 ] ] -RRB- cord-019051-gtruu1op 446 18 . . . cord-019051-gtruu1op 447 1 CD13 CD13 NNP cord-019051-gtruu1op 447 2 ( ( -LRB- cord-019051-gtruu1op 447 3 human human JJ cord-019051-gtruu1op 447 4 aminopeptidase aminopeptidase NN cord-019051-gtruu1op 447 5 N N NNP cord-019051-gtruu1op 447 6 , , , cord-019051-gtruu1op 447 7 APN APN NNP cord-019051-gtruu1op 447 8 ) ) -RRB- cord-019051-gtruu1op 447 9 , , , cord-019051-gtruu1op 447 10 a a DT cord-019051-gtruu1op 447 11 metalloproteinase metalloproteinase NN cord-019051-gtruu1op 447 12 located locate VBN cord-019051-gtruu1op 447 13 on on IN cord-019051-gtruu1op 447 14 the the DT cord-019051-gtruu1op 447 15 surface surface NN cord-019051-gtruu1op 447 16 of of IN cord-019051-gtruu1op 447 17 epithelial epithelial JJ cord-019051-gtruu1op 447 18 cells cell NNS cord-019051-gtruu1op 447 19 , , , cord-019051-gtruu1op 447 20 has have VBZ cord-019051-gtruu1op 447 21 been be VBN cord-019051-gtruu1op 447 22 identified identify VBN cord-019051-gtruu1op 447 23 as as IN cord-019051-gtruu1op 447 24 the the DT cord-019051-gtruu1op 447 25 cell cell NN cord-019051-gtruu1op 447 26 receptor receptor NN cord-019051-gtruu1op 447 27 for for IN cord-019051-gtruu1op 447 28 HCoV-229E HCoV-229E NNP cord-019051-gtruu1op 447 29 [ [ -LRB- cord-019051-gtruu1op 447 30 180 180 CD cord-019051-gtruu1op 447 31 ] ] -RRB- cord-019051-gtruu1op 447 32 . . . cord-019051-gtruu1op 448 1 A a DT cord-019051-gtruu1op 448 2 metallopeptidase metallopeptidase NN cord-019051-gtruu1op 448 3 , , , cord-019051-gtruu1op 448 4 angiotensin angiotensin NN cord-019051-gtruu1op 448 5 converting convert VBG cord-019051-gtruu1op 448 6 enzyme enzyme NN cord-019051-gtruu1op 448 7 2 2 CD cord-019051-gtruu1op 448 8 ( ( -LRB- cord-019051-gtruu1op 448 9 ACE ACE NNP cord-019051-gtruu1op 448 10 2 2 CD cord-019051-gtruu1op 448 11 ) ) -RRB- cord-019051-gtruu1op 448 12 may may MD cord-019051-gtruu1op 448 13 be be VB cord-019051-gtruu1op 448 14 the the DT cord-019051-gtruu1op 448 15 cell cell NN cord-019051-gtruu1op 448 16 receptor receptor NN cord-019051-gtruu1op 448 17 for for IN cord-019051-gtruu1op 448 18 SARS SARS NNP cord-019051-gtruu1op 448 19 - - HYPH cord-019051-gtruu1op 448 20 CoV CoV NNP cord-019051-gtruu1op 448 21 [ [ -LRB- cord-019051-gtruu1op 448 22 181 181 CD cord-019051-gtruu1op 448 23 ] ] -RRB- cord-019051-gtruu1op 448 24 . . . cord-019051-gtruu1op 449 1 Binding bind VBG cord-019051-gtruu1op 449 2 of of IN cord-019051-gtruu1op 449 3 the the DT cord-019051-gtruu1op 449 4 S S NNP cord-019051-gtruu1op 449 5 protein protein NN cord-019051-gtruu1op 449 6 to to IN cord-019051-gtruu1op 449 7 the the DT cord-019051-gtruu1op 449 8 cell cell NN cord-019051-gtruu1op 449 9 receptor receptor NN cord-019051-gtruu1op 449 10 induces induce VBZ cord-019051-gtruu1op 449 11 conformational conformational JJ cord-019051-gtruu1op 449 12 changes change NNS cord-019051-gtruu1op 449 13 in in IN cord-019051-gtruu1op 449 14 S S NNP cord-019051-gtruu1op 449 15 that that WDT cord-019051-gtruu1op 449 16 triggers trigger VBZ cord-019051-gtruu1op 449 17 fusogenic fusogenic JJ cord-019051-gtruu1op 449 18 activity activity NN cord-019051-gtruu1op 449 19 [ [ -LRB- cord-019051-gtruu1op 449 20 182 182 CD cord-019051-gtruu1op 449 21 ] ] -RRB- cord-019051-gtruu1op 449 22 . . . cord-019051-gtruu1op 450 1 The the DT cord-019051-gtruu1op 450 2 coronavirus coronavirus NN cord-019051-gtruu1op 450 3 genome genome NN cord-019051-gtruu1op 450 4 can can MD cord-019051-gtruu1op 450 5 only only RB cord-019051-gtruu1op 450 6 be be VB cord-019051-gtruu1op 450 7 released release VBN cord-019051-gtruu1op 450 8 into into IN cord-019051-gtruu1op 450 9 the the DT cord-019051-gtruu1op 450 10 cytoplasm cytoplasm NN cord-019051-gtruu1op 450 11 after after IN cord-019051-gtruu1op 450 12 fusion fusion NN cord-019051-gtruu1op 450 13 of of IN cord-019051-gtruu1op 450 14 the the DT cord-019051-gtruu1op 450 15 envelope envelope NN cord-019051-gtruu1op 450 16 with with IN cord-019051-gtruu1op 450 17 the the DT cord-019051-gtruu1op 450 18 cell cell NN cord-019051-gtruu1op 450 19 membrane membrane NN cord-019051-gtruu1op 450 20 which which WDT cord-019051-gtruu1op 450 21 is be VBZ cord-019051-gtruu1op 450 22 mediated mediate VBN cord-019051-gtruu1op 450 23 through through IN cord-019051-gtruu1op 450 24 the the DT cord-019051-gtruu1op 450 25 S2 S2 NNP cord-019051-gtruu1op 450 26 region region NN cord-019051-gtruu1op 450 27 of of IN cord-019051-gtruu1op 450 28 the the DT cord-019051-gtruu1op 450 29 S S NNP cord-019051-gtruu1op 450 30 protein protein NN cord-019051-gtruu1op 450 31 [ [ -LRB- cord-019051-gtruu1op 450 32 173 173 CD cord-019051-gtruu1op 450 33 , , , cord-019051-gtruu1op 450 34 183 183 CD cord-019051-gtruu1op 450 35 ] ] -RRB- cord-019051-gtruu1op 450 36 . . . cord-019051-gtruu1op 451 1 Replication replication NN cord-019051-gtruu1op 451 2 occurs occur VBZ cord-019051-gtruu1op 451 3 within within IN cord-019051-gtruu1op 451 4 the the DT cord-019051-gtruu1op 451 5 cytoplasm cytoplasm NN cord-019051-gtruu1op 451 6 . . . cord-019051-gtruu1op 452 1 Early early RB cord-019051-gtruu1op 452 2 during during IN cord-019051-gtruu1op 452 3 infection infection NN cord-019051-gtruu1op 452 4 the the DT cord-019051-gtruu1op 452 5 genomic genomic JJ cord-019051-gtruu1op 452 6 RNA RNA NNP cord-019051-gtruu1op 452 7 is be VBZ cord-019051-gtruu1op 452 8 released release VBN cord-019051-gtruu1op 452 9 and and CC cord-019051-gtruu1op 452 10 acts act VBZ cord-019051-gtruu1op 452 11 as as IN cord-019051-gtruu1op 452 12 an an DT cord-019051-gtruu1op 452 13 mRNA mrna NN cord-019051-gtruu1op 452 14 for for IN cord-019051-gtruu1op 452 15 the the DT cord-019051-gtruu1op 452 16 translation translation NN cord-019051-gtruu1op 452 17 of of IN cord-019051-gtruu1op 452 18 the the DT cord-019051-gtruu1op 452 19 first first JJ cord-019051-gtruu1op 452 20 gene gene NN cord-019051-gtruu1op 452 21 , , , cord-019051-gtruu1op 452 22 the the DT cord-019051-gtruu1op 452 23 polymerase polymerase NN cord-019051-gtruu1op 452 24 . . . cord-019051-gtruu1op 453 1 mRNAs mRNAs NNPS cord-019051-gtruu1op 453 2 for for IN cord-019051-gtruu1op 453 3 the the DT cord-019051-gtruu1op 453 4 other other JJ cord-019051-gtruu1op 453 5 genes gene NNS cord-019051-gtruu1op 453 6 are be VBP cord-019051-gtruu1op 453 7 generated generate VBN cord-019051-gtruu1op 453 8 subsequently subsequently RB cord-019051-gtruu1op 453 9 . . . cord-019051-gtruu1op 454 1 In in IN cord-019051-gtruu1op 454 2 general general JJ cord-019051-gtruu1op 454 3 , , , cord-019051-gtruu1op 454 4 coronaviruses coronaviruse NNS cord-019051-gtruu1op 454 5 have have VBP cord-019051-gtruu1op 454 6 several several JJ cord-019051-gtruu1op 454 7 3 3 CD cord-019051-gtruu1op 454 8 ' ' '' cord-019051-gtruu1op 454 9 co co JJ cord-019051-gtruu1op 454 10 - - JJ cord-019051-gtruu1op 454 11 terminal terminal JJ cord-019051-gtruu1op 454 12 subgenomic subgenomic NNP cord-019051-gtruu1op 454 13 mRNAs mRNAs NNPS cord-019051-gtruu1op 454 14 , , , cord-019051-gtruu1op 454 15 socalled socalled JJ cord-019051-gtruu1op 454 16 ' ' '' cord-019051-gtruu1op 454 17 nested nested JJ cord-019051-gtruu1op 454 18 set set NN cord-019051-gtruu1op 454 19 ' ' '' cord-019051-gtruu1op 454 20 . . . cord-019051-gtruu1op 455 1 The the DT cord-019051-gtruu1op 455 2 unique unique JJ cord-019051-gtruu1op 455 3 part part NN cord-019051-gtruu1op 455 4 of of IN cord-019051-gtruu1op 455 5 each each DT cord-019051-gtruu1op 455 6 mRNA mrna NN cord-019051-gtruu1op 455 7 ( ( -LRB- cord-019051-gtruu1op 455 8 which which WDT cord-019051-gtruu1op 455 9 is be VBZ cord-019051-gtruu1op 455 10 not not RB cord-019051-gtruu1op 455 11 within within IN cord-019051-gtruu1op 455 12 the the DT cord-019051-gtruu1op 455 13 next next JJ cord-019051-gtruu1op 455 14 smaller small JJR cord-019051-gtruu1op 455 15 mRNA mRNA NNP cord-019051-gtruu1op 455 16 ) ) -RRB- cord-019051-gtruu1op 455 17 is be VBZ cord-019051-gtruu1op 455 18 translated translate VBN cord-019051-gtruu1op 455 19 during during IN cord-019051-gtruu1op 455 20 the the DT cord-019051-gtruu1op 455 21 replication replication NN cord-019051-gtruu1op 455 22 cycle cycle NN cord-019051-gtruu1op 455 23 . . . cord-019051-gtruu1op 456 1 At at IN cord-019051-gtruu1op 456 2 the the DT cord-019051-gtruu1op 456 3 5 5 CD cord-019051-gtruu1op 456 4 ' ' NN cord-019051-gtruu1op 456 5 end end NN cord-019051-gtruu1op 456 6 of of IN cord-019051-gtruu1op 456 7 each each DT cord-019051-gtruu1op 456 8 gene gene NN cord-019051-gtruu1op 456 9 there there EX cord-019051-gtruu1op 456 10 is be VBZ cord-019051-gtruu1op 456 11 a a DT cord-019051-gtruu1op 456 12 sequence sequence NN cord-019051-gtruu1op 456 13 that that WDT cord-019051-gtruu1op 456 14 is be VBZ cord-019051-gtruu1op 456 15 common common JJ cord-019051-gtruu1op 456 16 to to IN cord-019051-gtruu1op 456 17 all all DT cord-019051-gtruu1op 456 18 genes gene NNS cord-019051-gtruu1op 456 19 , , , cord-019051-gtruu1op 456 20 the the DT cord-019051-gtruu1op 456 21 so so RB cord-019051-gtruu1op 456 22 - - HYPH cord-019051-gtruu1op 456 23 called call VBN cord-019051-gtruu1op 456 24 ' ' '' cord-019051-gtruu1op 456 25 transcription transcription NN cord-019051-gtruu1op 456 26 - - HYPH cord-019051-gtruu1op 456 27 associated associate VBN cord-019051-gtruu1op 456 28 sequence sequence NN cord-019051-gtruu1op 456 29 ' ' '' cord-019051-gtruu1op 456 30 , , , cord-019051-gtruu1op 456 31 which which WDT cord-019051-gtruu1op 456 32 , , , cord-019051-gtruu1op 456 33 as as IN cord-019051-gtruu1op 456 34 the the DT cord-019051-gtruu1op 456 35 name name NN cord-019051-gtruu1op 456 36 implies imply VBZ cord-019051-gtruu1op 456 37 , , , cord-019051-gtruu1op 456 38 is be VBZ cord-019051-gtruu1op 456 39 associated associate VBN cord-019051-gtruu1op 456 40 with with IN cord-019051-gtruu1op 456 41 the the DT cord-019051-gtruu1op 456 42 discontinuous discontinuous JJ cord-019051-gtruu1op 456 43 transcription transcription NN cord-019051-gtruu1op 456 44 process process NN cord-019051-gtruu1op 456 45 ( ( -LRB- cord-019051-gtruu1op 456 46 reviewed review VBN cord-019051-gtruu1op 456 47 in in IN cord-019051-gtruu1op 456 48 [ [ -LRB- cord-019051-gtruu1op 456 49 171 171 CD cord-019051-gtruu1op 456 50 ] ] -RRB- cord-019051-gtruu1op 456 51 ) ) -RRB- cord-019051-gtruu1op 456 52 . . . cord-019051-gtruu1op 457 1 The the DT cord-019051-gtruu1op 457 2 various various JJ cord-019051-gtruu1op 457 3 mechanisms mechanism NNS cord-019051-gtruu1op 457 4 that that WDT cord-019051-gtruu1op 457 5 have have VBP cord-019051-gtruu1op 457 6 been be VBN cord-019051-gtruu1op 457 7 proposed propose VBN cord-019051-gtruu1op 457 8 for for IN cord-019051-gtruu1op 457 9 the the DT cord-019051-gtruu1op 457 10 production production NN cord-019051-gtruu1op 457 11 of of IN cord-019051-gtruu1op 457 12 subgenomic subgenomic NNP cord-019051-gtruu1op 457 13 mRNAs mRNAs NNPS cord-019051-gtruu1op 457 14 have have VBP cord-019051-gtruu1op 457 15 been be VBN cord-019051-gtruu1op 457 16 reviewed review VBN cord-019051-gtruu1op 457 17 elsewhere elsewhere RB cord-019051-gtruu1op 457 18 [ [ -LRB- cord-019051-gtruu1op 457 19 184 184 CD cord-019051-gtruu1op 457 20 ] ] -RRB- cord-019051-gtruu1op 457 21 . . . cord-019051-gtruu1op 458 1 Human human JJ cord-019051-gtruu1op 458 2 coronaviruses coronaviruse NNS cord-019051-gtruu1op 458 3 are be VBP cord-019051-gtruu1op 458 4 generally generally RB cord-019051-gtruu1op 458 5 thought think VBN cord-019051-gtruu1op 458 6 of of IN cord-019051-gtruu1op 458 7 as as RB cord-019051-gtruu1op 458 8 common common JJ cord-019051-gtruu1op 458 9 cold cold JJ cord-019051-gtruu1op 458 10 agents agent NNS cord-019051-gtruu1op 458 11 . . . cord-019051-gtruu1op 459 1 This this DT cord-019051-gtruu1op 459 2 role role NN cord-019051-gtruu1op 459 3 was be VBD cord-019051-gtruu1op 459 4 confirmed confirm VBN cord-019051-gtruu1op 459 5 when when WRB cord-019051-gtruu1op 459 6 healthy healthy JJ cord-019051-gtruu1op 459 7 volunteers volunteer NNS cord-019051-gtruu1op 459 8 were be VBD cord-019051-gtruu1op 459 9 infected infect VBN cord-019051-gtruu1op 459 10 with with IN cord-019051-gtruu1op 459 11 HCoV HCoV NNP cord-019051-gtruu1op 459 12 - - HYPH cord-019051-gtruu1op 459 13 OC43 OC43 NNP cord-019051-gtruu1op 459 14 and and CC cord-019051-gtruu1op 459 15 HCoV-229E HCoV-229E NNP cord-019051-gtruu1op 459 16 and and CC cord-019051-gtruu1op 459 17 developed develop VBD cord-019051-gtruu1op 459 18 classical classical JJ cord-019051-gtruu1op 459 19 common common JJ cord-019051-gtruu1op 459 20 cold cold JJ cord-019051-gtruu1op 459 21 symptoms symptom NNS cord-019051-gtruu1op 459 22 [ [ -LRB- cord-019051-gtruu1op 459 23 185 185 CD cord-019051-gtruu1op 459 24 ] ] -RRB- cord-019051-gtruu1op 459 25 . . . cord-019051-gtruu1op 460 1 Whereas whereas IN cord-019051-gtruu1op 460 2 most most JJS cord-019051-gtruu1op 460 3 infections infection NNS cord-019051-gtruu1op 460 4 result result VBP cord-019051-gtruu1op 460 5 in in IN cord-019051-gtruu1op 460 6 mild mild JJ cord-019051-gtruu1op 460 7 disease disease NN cord-019051-gtruu1op 460 8 or or CC cord-019051-gtruu1op 460 9 are be VBP cord-019051-gtruu1op 460 10 even even RB cord-019051-gtruu1op 460 11 asymptomatic asymptomatic JJ cord-019051-gtruu1op 460 12 , , , cord-019051-gtruu1op 460 13 additional additional JJ cord-019051-gtruu1op 460 14 factors factor NNS cord-019051-gtruu1op 460 15 like like IN cord-019051-gtruu1op 460 16 immunosuppression immunosuppression NN cord-019051-gtruu1op 460 17 or or CC cord-019051-gtruu1op 460 18 coinfections coinfection NNS cord-019051-gtruu1op 460 19 might may MD cord-019051-gtruu1op 460 20 cause cause VB cord-019051-gtruu1op 460 21 severe severe JJ cord-019051-gtruu1op 460 22 disease disease NN cord-019051-gtruu1op 460 23 , , , cord-019051-gtruu1op 460 24 even even RB cord-019051-gtruu1op 460 25 pneumonia pneumonia NN cord-019051-gtruu1op 460 26 [ [ -LRB- cord-019051-gtruu1op 460 27 186 186 CD cord-019051-gtruu1op 460 28 , , , cord-019051-gtruu1op 460 29 187 187 CD cord-019051-gtruu1op 460 30 ] ] -RRB- cord-019051-gtruu1op 460 31 . . . cord-019051-gtruu1op 461 1 It -PRON- PRP cord-019051-gtruu1op 461 2 is be VBZ cord-019051-gtruu1op 461 3 not not RB cord-019051-gtruu1op 461 4 clear clear JJ cord-019051-gtruu1op 461 5 whether whether IN cord-019051-gtruu1op 461 6 HCoV-229E HCoV-229E NNP cord-019051-gtruu1op 461 7 and and CC cord-019051-gtruu1op 461 8 HCoV HCoV NNP cord-019051-gtruu1op 461 9 - - HYPH cord-019051-gtruu1op 461 10 OC43 OC43 NNP cord-019051-gtruu1op 461 11 infect infect VB cord-019051-gtruu1op 461 12 the the DT cord-019051-gtruu1op 461 13 lower low JJR cord-019051-gtruu1op 461 14 respiratory respiratory JJ cord-019051-gtruu1op 461 15 tract tract NN cord-019051-gtruu1op 461 16 in in IN cord-019051-gtruu1op 461 17 otherwise otherwise RB cord-019051-gtruu1op 461 18 healthy healthy JJ cord-019051-gtruu1op 461 19 people people NNS cord-019051-gtruu1op 461 20 , , , cord-019051-gtruu1op 461 21 because because IN cord-019051-gtruu1op 461 22 only only RB cord-019051-gtruu1op 461 23 URTI URTI NNP cord-019051-gtruu1op 461 24 was be VBD cord-019051-gtruu1op 461 25 observed observe VBN cord-019051-gtruu1op 461 26 in in IN cord-019051-gtruu1op 461 27 this this DT cord-019051-gtruu1op 461 28 population population NN cord-019051-gtruu1op 461 29 . . . cord-019051-gtruu1op 462 1 It -PRON- PRP cord-019051-gtruu1op 462 2 has have VBZ cord-019051-gtruu1op 462 3 been be VBN cord-019051-gtruu1op 462 4 suggested suggest VBN cord-019051-gtruu1op 462 5 that that IN cord-019051-gtruu1op 462 6 the the DT cord-019051-gtruu1op 462 7 lower low JJR cord-019051-gtruu1op 462 8 respiratory respiratory JJ cord-019051-gtruu1op 462 9 tract tract NN cord-019051-gtruu1op 462 10 is be VBZ cord-019051-gtruu1op 462 11 more more RBR cord-019051-gtruu1op 462 12 susceptible susceptible JJ cord-019051-gtruu1op 462 13 to to IN cord-019051-gtruu1op 462 14 HCoV hcov VB cord-019051-gtruu1op 462 15 infection infection NN cord-019051-gtruu1op 462 16 in in IN cord-019051-gtruu1op 462 17 children child NNS cord-019051-gtruu1op 462 18 [ [ -LRB- cord-019051-gtruu1op 462 19 187 187 CD cord-019051-gtruu1op 462 20 ] ] -RRB- cord-019051-gtruu1op 462 21 . . . cord-019051-gtruu1op 463 1 Most Most JJS cord-019051-gtruu1op 463 2 studies study NNS cord-019051-gtruu1op 463 3 were be VBD cord-019051-gtruu1op 463 4 performed perform VBN cord-019051-gtruu1op 463 5 in in IN cord-019051-gtruu1op 463 6 healthy healthy JJ cord-019051-gtruu1op 463 7 adults adult NNS cord-019051-gtruu1op 463 8 and and CC cord-019051-gtruu1op 463 9 there there EX cord-019051-gtruu1op 463 10 is be VBZ cord-019051-gtruu1op 463 11 less less JJR cord-019051-gtruu1op 463 12 information information NN cord-019051-gtruu1op 463 13 about about IN cord-019051-gtruu1op 463 14 the the DT cord-019051-gtruu1op 463 15 most most RBS cord-019051-gtruu1op 463 16 susceptible susceptible JJ cord-019051-gtruu1op 463 17 and and CC cord-019051-gtruu1op 463 18 vulnerable vulnerable JJ cord-019051-gtruu1op 463 19 population population NN cord-019051-gtruu1op 463 20 , , , cord-019051-gtruu1op 463 21 children child NNS cord-019051-gtruu1op 463 22 and and CC cord-019051-gtruu1op 463 23 elderly elderly JJ cord-019051-gtruu1op 463 24 . . . cord-019051-gtruu1op 464 1 However however RB cord-019051-gtruu1op 464 2 , , , cord-019051-gtruu1op 464 3 HCoV-229E HCoV-229E NNP cord-019051-gtruu1op 464 4 and and CC cord-019051-gtruu1op 464 5 HCoV HCoV NNP cord-019051-gtruu1op 464 6 - - HYPH cord-019051-gtruu1op 464 7 OC43 OC43 NNP cord-019051-gtruu1op 464 8 nucleic nucleic JJ cord-019051-gtruu1op 464 9 acid acid NN cord-019051-gtruu1op 464 10 were be VBD cord-019051-gtruu1op 464 11 frequently frequently RB cord-019051-gtruu1op 464 12 detected detect VBN cord-019051-gtruu1op 464 13 in in IN cord-019051-gtruu1op 464 14 children child NNS cord-019051-gtruu1op 464 15 with with IN cord-019051-gtruu1op 464 16 respiratory respiratory JJ cord-019051-gtruu1op 464 17 tract tract NN cord-019051-gtruu1op 464 18 disease disease NN cord-019051-gtruu1op 464 19 ( ( -LRB- cord-019051-gtruu1op 464 20 11 11 CD cord-019051-gtruu1op 464 21 % % NN cord-019051-gtruu1op 464 22 ) ) -RRB- cord-019051-gtruu1op 464 23 using use VBG cord-019051-gtruu1op 464 24 RT RT NNP cord-019051-gtruu1op 464 25 - - HYPH cord-019051-gtruu1op 464 26 PCR PCR NNP cord-019051-gtruu1op 464 27 , , , cord-019051-gtruu1op 464 28 whereas whereas IN cord-019051-gtruu1op 464 29 in in IN cord-019051-gtruu1op 464 30 an an DT cord-019051-gtruu1op 464 31 otherwise otherwise RB cord-019051-gtruu1op 464 32 healthy healthy JJ cord-019051-gtruu1op 464 33 control control NN cord-019051-gtruu1op 464 34 group group NN cord-019051-gtruu1op 464 35 ( ( -LRB- cord-019051-gtruu1op 464 36 asymptomatic asymptomatic JJ cord-019051-gtruu1op 464 37 bone bone NN cord-019051-gtruu1op 464 38 marrow marrow NN cord-019051-gtruu1op 464 39 recipients recipient NNS cord-019051-gtruu1op 464 40 ) ) -RRB- cord-019051-gtruu1op 464 41 only only RB cord-019051-gtruu1op 464 42 one one CD cord-019051-gtruu1op 464 43 sample sample NN cord-019051-gtruu1op 464 44 tested test VBN cord-019051-gtruu1op 464 45 positive positive JJ cord-019051-gtruu1op 464 46 ( ( -LRB- cord-019051-gtruu1op 464 47 0.37 0.37 CD cord-019051-gtruu1op 464 48 % % NN cord-019051-gtruu1op 464 49 , , , cord-019051-gtruu1op 464 50 p p NN cord-019051-gtruu1op 464 51 < < XX cord-019051-gtruu1op 464 52 0.01 0.01 CD cord-019051-gtruu1op 464 53 ) ) -RRB- cord-019051-gtruu1op 465 1 [ [ -LRB- cord-019051-gtruu1op 465 2 188 188 CD cord-019051-gtruu1op 465 3 ] ] -RRB- cord-019051-gtruu1op 465 4 . . . cord-019051-gtruu1op 466 1 This this DT cord-019051-gtruu1op 466 2 finding finding NN cord-019051-gtruu1op 466 3 suggests suggest VBZ cord-019051-gtruu1op 466 4 that that IN cord-019051-gtruu1op 466 5 these these DT cord-019051-gtruu1op 466 6 coronaviruses coronaviruse NNS cord-019051-gtruu1op 466 7 cause cause VBP cord-019051-gtruu1op 466 8 upper upper JJ cord-019051-gtruu1op 466 9 and and CC cord-019051-gtruu1op 466 10 lower low JJR cord-019051-gtruu1op 466 11 respiratory respiratory JJ cord-019051-gtruu1op 466 12 tract tract NN cord-019051-gtruu1op 466 13 diseases disease NNS cord-019051-gtruu1op 466 14 in in IN cord-019051-gtruu1op 466 15 children child NNS cord-019051-gtruu1op 466 16 that that WDT cord-019051-gtruu1op 466 17 are be VBP cord-019051-gtruu1op 466 18 more more RBR cord-019051-gtruu1op 466 19 severe severe JJ cord-019051-gtruu1op 466 20 than than IN cord-019051-gtruu1op 466 21 in in IN cord-019051-gtruu1op 466 22 adults adult NNS cord-019051-gtruu1op 466 23 . . . cord-019051-gtruu1op 467 1 It -PRON- PRP cord-019051-gtruu1op 467 2 has have VBZ cord-019051-gtruu1op 467 3 been be VBN cord-019051-gtruu1op 467 4 suggested suggest VBN cord-019051-gtruu1op 467 5 that that IN cord-019051-gtruu1op 467 6 up up IN cord-019051-gtruu1op 467 7 to to TO cord-019051-gtruu1op 467 8 30 30 CD cord-019051-gtruu1op 467 9 % % NN cord-019051-gtruu1op 467 10 of of IN cord-019051-gtruu1op 467 11 wheezing wheeze VBG cord-019051-gtruu1op 467 12 episodes episode NNS cord-019051-gtruu1op 467 13 in in IN cord-019051-gtruu1op 467 14 asthmatic asthmatic JJ cord-019051-gtruu1op 467 15 children child NNS cord-019051-gtruu1op 467 16 may may MD cord-019051-gtruu1op 467 17 be be VB cord-019051-gtruu1op 467 18 due due JJ cord-019051-gtruu1op 467 19 to to IN cord-019051-gtruu1op 467 20 coronavirus coronavirus NN cord-019051-gtruu1op 467 21 infections infection NNS cord-019051-gtruu1op 467 22 [ [ -LRB- cord-019051-gtruu1op 467 23 189 189 CD cord-019051-gtruu1op 467 24 ] ] -RRB- cord-019051-gtruu1op 467 25 . . . cord-019051-gtruu1op 468 1 HCoV HCoV NNP cord-019051-gtruu1op 469 1 -NL63 -NL63 : cord-019051-gtruu1op 469 2 was be VBD cord-019051-gtruu1op 469 3 detected detect VBN cord-019051-gtruu1op 469 4 in in IN cord-019051-gtruu1op 469 5 young young JJ cord-019051-gtruu1op 469 6 hospitalized hospitalize VBN cord-019051-gtruu1op 469 7 children child NNS cord-019051-gtruu1op 469 8 with with IN cord-019051-gtruu1op 469 9 severe severe JJ cord-019051-gtruu1op 469 10 LRTI LRTI NNS cord-019051-gtruu1op 469 11 [ [ -LRB- cord-019051-gtruu1op 469 12 190 190 CD cord-019051-gtruu1op 469 13 ] ] -RRB- cord-019051-gtruu1op 469 14 . . . cord-019051-gtruu1op 470 1 This this DT cord-019051-gtruu1op 470 2 virus virus NN cord-019051-gtruu1op 470 3 has have VBZ cord-019051-gtruu1op 470 4 also also RB cord-019051-gtruu1op 470 5 been be VBN cord-019051-gtruu1op 470 6 detected detect VBN cord-019051-gtruu1op 470 7 in in IN cord-019051-gtruu1op 470 8 elderly elderly JJ cord-019051-gtruu1op 470 9 patients patient NNS cord-019051-gtruu1op 470 10 with with IN cord-019051-gtruu1op 470 11 fatal fatal JJ cord-019051-gtruu1op 470 12 respiratory respiratory JJ cord-019051-gtruu1op 470 13 disease disease NN cord-019051-gtruu1op 470 14 [ [ -LRB- cord-019051-gtruu1op 470 15 191 191 CD cord-019051-gtruu1op 470 16 ] ] -RRB- cord-019051-gtruu1op 470 17 . . . cord-019051-gtruu1op 471 1 The the DT cord-019051-gtruu1op 471 2 risk risk NN cord-019051-gtruu1op 471 3 of of IN cord-019051-gtruu1op 471 4 developing develop VBG cord-019051-gtruu1op 471 5 croup croup NN cord-019051-gtruu1op 471 6 was be VBD cord-019051-gtruu1op 471 7 about about RB cord-019051-gtruu1op 471 8 6.6 6.6 CD cord-019051-gtruu1op 471 9 times time NNS cord-019051-gtruu1op 471 10 higher high JJR cord-019051-gtruu1op 471 11 in in IN cord-019051-gtruu1op 471 12 children child NNS cord-019051-gtruu1op 471 13 shown show VBN cord-019051-gtruu1op 471 14 to to TO cord-019051-gtruu1op 471 15 be be VB cord-019051-gtruu1op 471 16 positive positive JJ cord-019051-gtruu1op 471 17 for for IN cord-019051-gtruu1op 471 18 HCoV HCoV NNP cord-019051-gtruu1op 471 19 - - HYPH cord-019051-gtruu1op 471 20 NL63 NL63 NNP cord-019051-gtruu1op 471 21 than than IN cord-019051-gtruu1op 471 22 in in IN cord-019051-gtruu1op 471 23 those those DT cord-019051-gtruu1op 471 24 who who WP cord-019051-gtruu1op 471 25 tested test VBD cord-019051-gtruu1op 471 26 negative negative JJ cord-019051-gtruu1op 471 27 [ [ -LRB- cord-019051-gtruu1op 471 28 192 192 CD cord-019051-gtruu1op 471 29 , , , cord-019051-gtruu1op 471 30 193 193 CD cord-019051-gtruu1op 471 31 ] ] -RRB- cord-019051-gtruu1op 471 32 . . . cord-019051-gtruu1op 472 1 HCoV HCoV NNP cord-019051-gtruu1op 472 2 - - HYPH cord-019051-gtruu1op 472 3 HKU1 HKU1 NNP cord-019051-gtruu1op 472 4 was be VBD cord-019051-gtruu1op 472 5 first first RB cord-019051-gtruu1op 472 6 detected detect VBN cord-019051-gtruu1op 472 7 in in IN cord-019051-gtruu1op 472 8 elderly elderly JJ cord-019051-gtruu1op 472 9 and and CC cord-019051-gtruu1op 472 10 children child NNS cord-019051-gtruu1op 472 11 with with IN cord-019051-gtruu1op 472 12 underlying underlie VBG cord-019051-gtruu1op 472 13 disease disease NN cord-019051-gtruu1op 472 14 [ [ -LRB- cord-019051-gtruu1op 472 15 194 194 CD cord-019051-gtruu1op 472 16 ] ] -RRB- cord-019051-gtruu1op 472 17 . . . cord-019051-gtruu1op 473 1 Symptoms symptom NNS cord-019051-gtruu1op 473 2 of of IN cord-019051-gtruu1op 473 3 HCoV HCoV NNP cord-019051-gtruu1op 473 4 - - HYPH cord-019051-gtruu1op 473 5 HKU1 HKU1 NNP cord-019051-gtruu1op 473 6 include include VBP cord-019051-gtruu1op 473 7 rhinorrhea rhinorrhea NN cord-019051-gtruu1op 473 8 , , , cord-019051-gtruu1op 473 9 fever fever NN cord-019051-gtruu1op 473 10 , , , cord-019051-gtruu1op 473 11 coughing cough VBG cord-019051-gtruu1op 473 12 , , , cord-019051-gtruu1op 473 13 and and CC cord-019051-gtruu1op 473 14 wheezing wheeze VBG cord-019051-gtruu1op 473 15 as as RB cord-019051-gtruu1op 473 16 well well RB cord-019051-gtruu1op 473 17 as as IN cord-019051-gtruu1op 473 18 bronchiolitis bronchiolitis NN cord-019051-gtruu1op 473 19 and and CC cord-019051-gtruu1op 473 20 pneumonia pneumonia NN cord-019051-gtruu1op 473 21 [ [ -LRB- cord-019051-gtruu1op 473 22 195 195 CD cord-019051-gtruu1op 473 23 ] ] -RRB- cord-019051-gtruu1op 473 24 . . . cord-019051-gtruu1op 474 1 HCoV HCoV NNP cord-019051-gtruu1op 474 2 - - HYPH cord-019051-gtruu1op 474 3 HKU1 HKU1 NNP cord-019051-gtruu1op 474 4 might may MD cord-019051-gtruu1op 474 5 also also RB cord-019051-gtruu1op 474 6 cause cause VB cord-019051-gtruu1op 474 7 gastrointestinal gastrointestinal JJ cord-019051-gtruu1op 474 8 disease disease NN cord-019051-gtruu1op 474 9 [ [ -LRB- cord-019051-gtruu1op 474 10 196 196 CD cord-019051-gtruu1op 474 11 ] ] -RRB- cord-019051-gtruu1op 474 12 . . . cord-019051-gtruu1op 475 1 HCoV HCoV NNP cord-019051-gtruu1op 475 2 infection infection NN cord-019051-gtruu1op 475 3 results result NNS cord-019051-gtruu1op 475 4 in in IN cord-019051-gtruu1op 475 5 antibody antibody NN cord-019051-gtruu1op 475 6 titers titer NNS cord-019051-gtruu1op 475 7 in in IN cord-019051-gtruu1op 475 8 serum serum NN cord-019051-gtruu1op 475 9 . . . cord-019051-gtruu1op 476 1 Secretory secretory JJ cord-019051-gtruu1op 476 2 antibodies antibody NNS cord-019051-gtruu1op 476 3 can can MD cord-019051-gtruu1op 476 4 be be VB cord-019051-gtruu1op 476 5 detected detect VBN cord-019051-gtruu1op 476 6 in in IN cord-019051-gtruu1op 476 7 the the DT cord-019051-gtruu1op 476 8 respiratory respiratory JJ cord-019051-gtruu1op 476 9 and and CC cord-019051-gtruu1op 476 10 enteric enteric JJ cord-019051-gtruu1op 476 11 tracts tract NNS cord-019051-gtruu1op 476 12 ( ( -LRB- cord-019051-gtruu1op 476 13 and and CC cord-019051-gtruu1op 476 14 in in IN cord-019051-gtruu1op 476 15 milk milk NN cord-019051-gtruu1op 476 16 or or CC cord-019051-gtruu1op 476 17 colostrum colostrum NN cord-019051-gtruu1op 476 18 ) ) -RRB- cord-019051-gtruu1op 477 1 [ [ -LRB- cord-019051-gtruu1op 477 2 197 197 CD cord-019051-gtruu1op 477 3 ] ] -RRB- cord-019051-gtruu1op 477 4 . . . cord-019051-gtruu1op 478 1 Infections infection NNS cord-019051-gtruu1op 478 2 with with IN cord-019051-gtruu1op 478 3 HCoV hcov NN cord-019051-gtruu1op 478 4 peak peak NN cord-019051-gtruu1op 478 5 during during IN cord-019051-gtruu1op 478 6 winter winter NN cord-019051-gtruu1op 478 7 season season NN cord-019051-gtruu1op 478 8 [ [ -LRB- cord-019051-gtruu1op 478 9 198 198 CD cord-019051-gtruu1op 478 10 ] ] -RRB- cord-019051-gtruu1op 478 11 . . . cord-019051-gtruu1op 479 1 It -PRON- PRP cord-019051-gtruu1op 479 2 is be VBZ cord-019051-gtruu1op 479 3 estimated estimate VBN cord-019051-gtruu1op 479 4 that that IN cord-019051-gtruu1op 479 5 approximately approximately RB cord-019051-gtruu1op 479 6 25 25 CD cord-019051-gtruu1op 479 7 % % NN cord-019051-gtruu1op 479 8 of of IN cord-019051-gtruu1op 479 9 common common JJ cord-019051-gtruu1op 479 10 cold cold JJ cord-019051-gtruu1op 479 11 cases case NNS cord-019051-gtruu1op 479 12 are be VBP cord-019051-gtruu1op 479 13 caused cause VBN cord-019051-gtruu1op 479 14 by by IN cord-019051-gtruu1op 479 15 coronaviruses coronaviruse NNS cord-019051-gtruu1op 479 16 [ [ -LRB- cord-019051-gtruu1op 479 17 162 162 CD cord-019051-gtruu1op 479 18 ] ] -RRB- cord-019051-gtruu1op 479 19 . . . cord-019051-gtruu1op 480 1 Outbreaks outbreak NNS cord-019051-gtruu1op 480 2 of of IN cord-019051-gtruu1op 480 3 different different JJ cord-019051-gtruu1op 480 4 human human JJ cord-019051-gtruu1op 480 5 coronaviruses coronaviruse NNS cord-019051-gtruu1op 480 6 have have VBP cord-019051-gtruu1op 480 7 found find VBN cord-019051-gtruu1op 480 8 to to IN cord-019051-gtruu1op 480 9 alternate alternate JJ cord-019051-gtruu1op 480 10 every every DT cord-019051-gtruu1op 480 11 2 2 CD cord-019051-gtruu1op 480 12 - - SYM cord-019051-gtruu1op 480 13 3 3 CD cord-019051-gtruu1op 480 14 years year NNS cord-019051-gtruu1op 480 15 [ [ -LRB- cord-019051-gtruu1op 480 16 197 197 CD cord-019051-gtruu1op 480 17 ] ] -RRB- cord-019051-gtruu1op 480 18 . . . cord-019051-gtruu1op 481 1 Although although IN cord-019051-gtruu1op 481 2 early early JJ cord-019051-gtruu1op 481 3 studies study NNS cord-019051-gtruu1op 481 4 demonstrated demonstrate VBD cord-019051-gtruu1op 481 5 that that IN cord-019051-gtruu1op 481 6 antibodies antibody NNS cord-019051-gtruu1op 481 7 against against IN cord-019051-gtruu1op 481 8 coronaviruses coronaviruse NNS cord-019051-gtruu1op 481 9 are be VBP cord-019051-gtruu1op 481 10 frequently frequently RB cord-019051-gtruu1op 481 11 present present JJ cord-019051-gtruu1op 481 12 in in IN cord-019051-gtruu1op 481 13 adults adult NNS cord-019051-gtruu1op 481 14 [ [ -LRB- cord-019051-gtruu1op 481 15 199 199 CD cord-019051-gtruu1op 481 16 ] ] -RRB- cord-019051-gtruu1op 481 17 , , , cord-019051-gtruu1op 481 18 new new JJ cord-019051-gtruu1op 481 19 studies study NNS cord-019051-gtruu1op 481 20 suggest suggest VBP cord-019051-gtruu1op 481 21 that that IN cord-019051-gtruu1op 481 22 there there EX cord-019051-gtruu1op 481 23 are be VBP cord-019051-gtruu1op 481 24 differences difference NNS cord-019051-gtruu1op 481 25 with with IN cord-019051-gtruu1op 481 26 respect respect NN cord-019051-gtruu1op 481 27 to to IN cord-019051-gtruu1op 481 28 the the DT cord-019051-gtruu1op 481 29 HCoV HCoV NNP cord-019051-gtruu1op 481 30 species specie NNS cord-019051-gtruu1op 481 31 . . . cord-019051-gtruu1op 482 1 Hofmann Hofmann NNP cord-019051-gtruu1op 482 2 et et NNP cord-019051-gtruu1op 482 3 al al NNP cord-019051-gtruu1op 482 4 . . . cord-019051-gtruu1op 483 1 [ [ -LRB- cord-019051-gtruu1op 483 2 200 200 CD cord-019051-gtruu1op 483 3 ] ] -RRB- cord-019051-gtruu1op 483 4 demonstrated demonstrate VBD cord-019051-gtruu1op 483 5 that that IN cord-019051-gtruu1op 483 6 infections infection NNS cord-019051-gtruu1op 483 7 with with IN cord-019051-gtruu1op 483 8 HCoV-229E HCoV-229E NNP cord-019051-gtruu1op 483 9 occur occur VBP cord-019051-gtruu1op 483 10 less less RBR cord-019051-gtruu1op 483 11 frequently frequently RB cord-019051-gtruu1op 483 12 than than IN cord-019051-gtruu1op 483 13 with with IN cord-019051-gtruu1op 483 14 HCoV HCoV NNP cord-019051-gtruu1op 483 15 - - HYPH cord-019051-gtruu1op 483 16 NL63 NL63 NNP cord-019051-gtruu1op 483 17 by by IN cord-019051-gtruu1op 483 18 measuring measure VBG cord-019051-gtruu1op 483 19 specific specific JJ cord-019051-gtruu1op 483 20 antibodies antibody NNS cord-019051-gtruu1op 483 21 neutralizing neutralize VBG cord-019051-gtruu1op 483 22 either either CC cord-019051-gtruu1op 483 23 HCoV HCoV NNP cord-019051-gtruu1op 483 24 - - HYPH cord-019051-gtruu1op 483 25 NL63 nl63 NN cord-019051-gtruu1op 484 1 or or CC cord-019051-gtruu1op 484 2 HCoV-229E. HCoV-229E. NNP cord-019051-gtruu1op 485 1 In in IN cord-019051-gtruu1op 485 2 addition addition NN cord-019051-gtruu1op 485 3 , , , cord-019051-gtruu1op 485 4 co co NN cord-019051-gtruu1op 485 5 - - NN cord-019051-gtruu1op 485 6 detection detection NN cord-019051-gtruu1op 485 7 of of IN cord-019051-gtruu1op 485 8 coronaviruses coronaviruse NNS cord-019051-gtruu1op 485 9 with with IN cord-019051-gtruu1op 485 10 other other JJ cord-019051-gtruu1op 485 11 viruses virus NNS cord-019051-gtruu1op 485 12 is be VBZ cord-019051-gtruu1op 485 13 common common JJ cord-019051-gtruu1op 485 14 [ [ -LRB- cord-019051-gtruu1op 485 15 187 187 CD cord-019051-gtruu1op 485 16 ] ] -RRB- cord-019051-gtruu1op 485 17 . . . cord-019051-gtruu1op 486 1 As as IN cord-019051-gtruu1op 486 2 with with IN cord-019051-gtruu1op 486 3 most most JJS cord-019051-gtruu1op 486 4 coronaviruses coronaviruse NNS cord-019051-gtruu1op 486 5 , , , cord-019051-gtruu1op 486 6 human human JJ cord-019051-gtruu1op 486 7 coronaviruses coronaviruse NNS cord-019051-gtruu1op 486 8 are be VBP cord-019051-gtruu1op 486 9 species specie NNS cord-019051-gtruu1op 486 10 specific specific JJ cord-019051-gtruu1op 486 11 . . . cord-019051-gtruu1op 487 1 However however RB cord-019051-gtruu1op 487 2 , , , cord-019051-gtruu1op 487 3 the the DT cord-019051-gtruu1op 487 4 SARS SARS NNP cord-019051-gtruu1op 487 5 coronavirus coronavirus NN cord-019051-gtruu1op 487 6 probably probably RB cord-019051-gtruu1op 487 7 originated originate VBD cord-019051-gtruu1op 487 8 from from IN cord-019051-gtruu1op 487 9 an an DT cord-019051-gtruu1op 487 10 animal animal NN cord-019051-gtruu1op 487 11 reservoir reservoir NN cord-019051-gtruu1op 487 12 , , , cord-019051-gtruu1op 487 13 presumably presumably RB cord-019051-gtruu1op 487 14 bats bat NNS cord-019051-gtruu1op 487 15 [ [ -LRB- cord-019051-gtruu1op 487 16 201 201 CD cord-019051-gtruu1op 487 17 , , , cord-019051-gtruu1op 487 18 202 202 CD cord-019051-gtruu1op 487 19 ] ] -RRB- cord-019051-gtruu1op 487 20 but but CC cord-019051-gtruu1op 487 21 was be VBD cord-019051-gtruu1op 487 22 transmitted transmit VBN cord-019051-gtruu1op 487 23 to to IN cord-019051-gtruu1op 487 24 humans human NNS cord-019051-gtruu1op 487 25 by by IN cord-019051-gtruu1op 487 26 civet civet NN cord-019051-gtruu1op 487 27 cats cat NNS cord-019051-gtruu1op 487 28 . . . cord-019051-gtruu1op 488 1 The the DT cord-019051-gtruu1op 488 2 transmission transmission NN cord-019051-gtruu1op 488 3 of of IN cord-019051-gtruu1op 488 4 human human JJ cord-019051-gtruu1op 488 5 coronaviruses coronaviruse NNS cord-019051-gtruu1op 488 6 from from IN cord-019051-gtruu1op 488 7 human human JJ cord-019051-gtruu1op 488 8 to to IN cord-019051-gtruu1op 488 9 human human JJ cord-019051-gtruu1op 488 10 occurs occur VBZ cord-019051-gtruu1op 488 11 via via IN cord-019051-gtruu1op 488 12 secretions secretion NNS cord-019051-gtruu1op 488 13 like like IN cord-019051-gtruu1op 488 14 aerosols aerosol NNS cord-019051-gtruu1op 488 15 and and CC cord-019051-gtruu1op 488 16 respiratory respiratory JJ cord-019051-gtruu1op 488 17 droplets droplet NNS cord-019051-gtruu1op 488 18 ( ( -LRB- cord-019051-gtruu1op 488 19 or or CC cord-019051-gtruu1op 488 20 , , , cord-019051-gtruu1op 488 21 in in IN cord-019051-gtruu1op 488 22 case case NN cord-019051-gtruu1op 488 23 of of IN cord-019051-gtruu1op 488 24 enteric enteric JJ cord-019051-gtruu1op 488 25 infection infection NN cord-019051-gtruu1op 488 26 , , , cord-019051-gtruu1op 488 27 feces fece NNS cord-019051-gtruu1op 488 28 ) ) -RRB- cord-019051-gtruu1op 488 29 [ [ -LRB- cord-019051-gtruu1op 488 30 197 197 CD cord-019051-gtruu1op 488 31 ] ] -RRB- cord-019051-gtruu1op 488 32 . . . cord-019051-gtruu1op 489 1 Adults adult NNS cord-019051-gtruu1op 489 2 with with IN cord-019051-gtruu1op 489 3 acute acute JJ cord-019051-gtruu1op 489 4 symptomatic symptomatic JJ cord-019051-gtruu1op 489 5 or or CC cord-019051-gtruu1op 489 6 inapparent inapparent JJ cord-019051-gtruu1op 489 7 infection infection NN cord-019051-gtruu1op 489 8 transmit transmit VBP cord-019051-gtruu1op 489 9 the the DT cord-019051-gtruu1op 489 10 virus virus NN cord-019051-gtruu1op 489 11 to to IN cord-019051-gtruu1op 489 12 infants infant NNS cord-019051-gtruu1op 489 13 who who WP cord-019051-gtruu1op 489 14 develop develop VBP cord-019051-gtruu1op 489 15 clinical clinical JJ cord-019051-gtruu1op 489 16 disease disease NN cord-019051-gtruu1op 489 17 [ [ -LRB- cord-019051-gtruu1op 489 18 162 162 CD cord-019051-gtruu1op 489 19 ] ] -RRB- cord-019051-gtruu1op 489 20 . . . cord-019051-gtruu1op 490 1 Diagnosis diagnosis NN cord-019051-gtruu1op 490 2 of of IN cord-019051-gtruu1op 490 3 HCoV HCoV NNP cord-019051-gtruu1op 490 4 infection infection NN cord-019051-gtruu1op 490 5 is be VBZ cord-019051-gtruu1op 490 6 more more RBR cord-019051-gtruu1op 490 7 clinical clinical JJ cord-019051-gtruu1op 490 8 ; ; . cord-019051-gtruu1op 491 1 an an DT cord-019051-gtruu1op 491 2 etiological etiological JJ cord-019051-gtruu1op 491 3 diagnosis diagnosis NN cord-019051-gtruu1op 491 4 , , , cord-019051-gtruu1op 491 5 however however RB cord-019051-gtruu1op 491 6 , , , cord-019051-gtruu1op 491 7 can can MD cord-019051-gtruu1op 491 8 be be VB cord-019051-gtruu1op 491 9 performed perform VBN cord-019051-gtruu1op 491 10 using use VBG cord-019051-gtruu1op 491 11 molecular molecular JJ cord-019051-gtruu1op 491 12 or or CC cord-019051-gtruu1op 491 13 immunological immunological JJ cord-019051-gtruu1op 491 14 techniques technique NNS cord-019051-gtruu1op 491 15 . . . cord-019051-gtruu1op 492 1 Vaccines vaccine NNS cord-019051-gtruu1op 492 2 against against IN cord-019051-gtruu1op 492 3 coronavirus coronavirus NN cord-019051-gtruu1op 492 4 diseases disease NNS cord-019051-gtruu1op 492 5 have have VBP cord-019051-gtruu1op 492 6 been be VBN cord-019051-gtruu1op 492 7 developed develop VBN cord-019051-gtruu1op 492 8 for for IN cord-019051-gtruu1op 492 9 domestic domestic JJ cord-019051-gtruu1op 492 10 animals animal NNS cord-019051-gtruu1op 492 11 because because IN cord-019051-gtruu1op 492 12 of of IN cord-019051-gtruu1op 492 13 the the DT cord-019051-gtruu1op 492 14 economic economic JJ cord-019051-gtruu1op 492 15 importance importance NN cord-019051-gtruu1op 492 16 [ [ -LRB- cord-019051-gtruu1op 492 17 197 197 CD cord-019051-gtruu1op 492 18 ] ] -RRB- cord-019051-gtruu1op 492 19 , , , cord-019051-gtruu1op 492 20 but but CC cord-019051-gtruu1op 492 21 not not RB cord-019051-gtruu1op 492 22 for for IN cord-019051-gtruu1op 492 23 humans human NNS cord-019051-gtruu1op 492 24 . . . cord-019051-gtruu1op 493 1 Recent recent JJ cord-019051-gtruu1op 493 2 antiviral antiviral JJ cord-019051-gtruu1op 493 3 strategies strategy NNS cord-019051-gtruu1op 493 4 against against IN cord-019051-gtruu1op 493 5 coronavirus coronavirus NN cord-019051-gtruu1op 493 6 infection infection NN cord-019051-gtruu1op 493 7 have have VBP cord-019051-gtruu1op 493 8 been be VBN cord-019051-gtruu1op 493 9 reviewed review VBN cord-019051-gtruu1op 493 10 elsewhere elsewhere RB cord-019051-gtruu1op 493 11 [ [ -LRB- cord-019051-gtruu1op 493 12 203 203 CD cord-019051-gtruu1op 493 13 ] ] -RRB- cord-019051-gtruu1op 493 14 . . . cord-019051-gtruu1op 494 1 These these DT cord-019051-gtruu1op 494 2 strategies strategy NNS cord-019051-gtruu1op 494 3 explore explore VBP cord-019051-gtruu1op 494 4 small small JJ cord-019051-gtruu1op 494 5 interfering interfere VBG cord-019051-gtruu1op 494 6 RNA RNA NNP cord-019051-gtruu1op 494 7 , , , cord-019051-gtruu1op 494 8 blocking block VBG cord-019051-gtruu1op 494 9 of of IN cord-019051-gtruu1op 494 10 viral viral JJ cord-019051-gtruu1op 494 11 entry entry NN cord-019051-gtruu1op 494 12 ( ( -LRB- cord-019051-gtruu1op 494 13 e.g. e.g. RB cord-019051-gtruu1op 494 14 , , , cord-019051-gtruu1op 494 15 using use VBG cord-019051-gtruu1op 494 16 carbohydrate carbohydrate NN cord-019051-gtruu1op 494 17 - - HYPH cord-019051-gtruu1op 494 18 binding bind VBG cord-019051-gtruu1op 494 19 agents agent NNS cord-019051-gtruu1op 494 20 ) ) -RRB- cord-019051-gtruu1op 494 21 or or CC cord-019051-gtruu1op 494 22 neutralizing neutralize VBG cord-019051-gtruu1op 494 23 antibodies antibody NNS cord-019051-gtruu1op 494 24 . . . cord-019051-gtruu1op 495 1 In in IN cord-019051-gtruu1op 495 2 addition addition NN cord-019051-gtruu1op 495 3 , , , cord-019051-gtruu1op 495 4 viral viral JJ cord-019051-gtruu1op 495 5 enzymes enzyme NNS cord-019051-gtruu1op 495 6 like like IN cord-019051-gtruu1op 495 7 protease protease NN cord-019051-gtruu1op 495 8 or or CC cord-019051-gtruu1op 495 9 helicase helicase NN cord-019051-gtruu1op 495 10 are be VBP cord-019051-gtruu1op 495 11 studied study VBN cord-019051-gtruu1op 495 12 as as IN cord-019051-gtruu1op 495 13 potential potential JJ cord-019051-gtruu1op 495 14 targets target NNS cord-019051-gtruu1op 495 15 for for IN cord-019051-gtruu1op 495 16 novel novel JJ cord-019051-gtruu1op 495 17 antivirals antiviral NNS cord-019051-gtruu1op 495 18 ( ( -LRB- cord-019051-gtruu1op 495 19 reviewed review VBN cord-019051-gtruu1op 495 20 in in IN cord-019051-gtruu1op 495 21 [ [ -LRB- cord-019051-gtruu1op 495 22 203 203 CD cord-019051-gtruu1op 495 23 ] ] -RRB- cord-019051-gtruu1op 495 24 ) ) -RRB- cord-019051-gtruu1op 495 25 . . . cord-019051-gtruu1op 496 1 According accord VBG cord-019051-gtruu1op 496 2 to to IN cord-019051-gtruu1op 496 3 estimates estimate NNS cord-019051-gtruu1op 496 4 from from IN cord-019051-gtruu1op 496 5 the the DT cord-019051-gtruu1op 496 6 WHO WHO NNP cord-019051-gtruu1op 496 7 , , , cord-019051-gtruu1op 496 8 the the DT cord-019051-gtruu1op 496 9 burden burden NN cord-019051-gtruu1op 496 10 of of IN cord-019051-gtruu1op 496 11 influenza influenza NN cord-019051-gtruu1op 496 12 in in IN cord-019051-gtruu1op 496 13 the the DT cord-019051-gtruu1op 496 14 USA USA NNP cord-019051-gtruu1op 496 15 is be VBZ cord-019051-gtruu1op 496 16 currently currently RB cord-019051-gtruu1op 496 17 estimated estimate VBN cord-019051-gtruu1op 496 18 to to TO cord-019051-gtruu1op 496 19 be be VB cord-019051-gtruu1op 496 20 25 25 CD cord-019051-gtruu1op 496 21 - - SYM cord-019051-gtruu1op 496 22 50 50 CD cord-019051-gtruu1op 496 23 million million CD cord-019051-gtruu1op 496 24 cases case NNS cord-019051-gtruu1op 496 25 per per IN cord-019051-gtruu1op 496 26 year year NN cord-019051-gtruu1op 496 27 , , , cord-019051-gtruu1op 496 28 leading lead VBG cord-019051-gtruu1op 496 29 to to IN cord-019051-gtruu1op 496 30 150 150 CD cord-019051-gtruu1op 496 31 000 000 CD cord-019051-gtruu1op 496 32 hospitalizations hospitalization NNS cord-019051-gtruu1op 496 33 and and CC cord-019051-gtruu1op 496 34 30 30 CD cord-019051-gtruu1op 496 35 000 000 CD cord-019051-gtruu1op 496 36 - - SYM cord-019051-gtruu1op 496 37 40 40 CD cord-019051-gtruu1op 496 38 000 000 CD cord-019051-gtruu1op 496 39 deaths death NNS cord-019051-gtruu1op 496 40 per per IN cord-019051-gtruu1op 496 41 year year NN cord-019051-gtruu1op 496 42 . . . cord-019051-gtruu1op 497 1 If if IN cord-019051-gtruu1op 497 2 these these DT cord-019051-gtruu1op 497 3 numbers number NNS cord-019051-gtruu1op 497 4 are be VBP cord-019051-gtruu1op 497 5 extrapolated extrapolate VBN cord-019051-gtruu1op 497 6 to to IN cord-019051-gtruu1op 497 7 the the DT cord-019051-gtruu1op 497 8 rest rest NN cord-019051-gtruu1op 497 9 of of IN cord-019051-gtruu1op 497 10 the the DT cord-019051-gtruu1op 497 11 world world NN cord-019051-gtruu1op 497 12 , , , cord-019051-gtruu1op 497 13 influenza influenza NN cord-019051-gtruu1op 497 14 virus virus NN cord-019051-gtruu1op 497 15 would would MD cord-019051-gtruu1op 497 16 infect infect VB cord-019051-gtruu1op 497 17 5 5 CD cord-019051-gtruu1op 497 18 - - SYM cord-019051-gtruu1op 497 19 15 15 CD cord-019051-gtruu1op 497 20 % % NN cord-019051-gtruu1op 497 21 of of IN cord-019051-gtruu1op 497 22 the the DT cord-019051-gtruu1op 497 23 world world NN cord-019051-gtruu1op 497 24 population population NN cord-019051-gtruu1op 497 25 , , , cord-019051-gtruu1op 497 26 causing cause VBG cord-019051-gtruu1op 497 27 3 3 CD cord-019051-gtruu1op 497 28 - - SYM cord-019051-gtruu1op 497 29 5 5 CD cord-019051-gtruu1op 497 30 million million CD cord-019051-gtruu1op 497 31 cases case NNS cord-019051-gtruu1op 497 32 of of IN cord-019051-gtruu1op 497 33 severe severe JJ cord-019051-gtruu1op 497 34 disease disease NN cord-019051-gtruu1op 497 35 and and CC cord-019051-gtruu1op 497 36 approximately approximately RB cord-019051-gtruu1op 497 37 0.5 0.5 CD cord-019051-gtruu1op 497 38 million million CD cord-019051-gtruu1op 497 39 deaths death NNS cord-019051-gtruu1op 497 40 per per IN cord-019051-gtruu1op 497 41 year year NN cord-019051-gtruu1op 497 42 . . . cord-019051-gtruu1op 498 1 Although although IN cord-019051-gtruu1op 498 2 this this DT cord-019051-gtruu1op 498 3 number number NN cord-019051-gtruu1op 498 4 is be VBZ cord-019051-gtruu1op 498 5 high high JJ cord-019051-gtruu1op 498 6 , , , cord-019051-gtruu1op 498 7 it -PRON- PRP cord-019051-gtruu1op 498 8 would would MD cord-019051-gtruu1op 498 9 only only RB cord-019051-gtruu1op 498 10 characterize characterize VB cord-019051-gtruu1op 498 11 inter inter JJ cord-019051-gtruu1op 498 12 - - JJ cord-019051-gtruu1op 498 13 pandemic pandemic JJ cord-019051-gtruu1op 498 14 influenza influenza NN cord-019051-gtruu1op 498 15 [ [ -LRB- cord-019051-gtruu1op 498 16 204 204 CD cord-019051-gtruu1op 498 17 ] ] -RRB- cord-019051-gtruu1op 498 18 . . . cord-019051-gtruu1op 499 1 Epidemics epidemic NNS cord-019051-gtruu1op 499 2 and and CC cord-019051-gtruu1op 499 3 outbreaks outbreak NNS cord-019051-gtruu1op 499 4 of of IN cord-019051-gtruu1op 499 5 influenza influenza NN cord-019051-gtruu1op 499 6 follow follow VB cord-019051-gtruu1op 499 7 a a DT cord-019051-gtruu1op 499 8 seasonal seasonal JJ cord-019051-gtruu1op 499 9 pattern pattern NN cord-019051-gtruu1op 499 10 , , , cord-019051-gtruu1op 499 11 which which WDT cord-019051-gtruu1op 499 12 differs differ VBZ cord-019051-gtruu1op 499 13 according accord VBG cord-019051-gtruu1op 499 14 to to IN cord-019051-gtruu1op 499 15 the the DT cord-019051-gtruu1op 499 16 region region NN cord-019051-gtruu1op 499 17 in in IN cord-019051-gtruu1op 499 18 the the DT cord-019051-gtruu1op 499 19 world world NN cord-019051-gtruu1op 499 20 : : : cord-019051-gtruu1op 500 1 in in IN cord-019051-gtruu1op 500 2 temperate temperate JJ cord-019051-gtruu1op 500 3 climate climate NN cord-019051-gtruu1op 500 4 zones zone NNS cord-019051-gtruu1op 500 5 , , , cord-019051-gtruu1op 500 6 seasonal seasonal JJ cord-019051-gtruu1op 500 7 epidemics epidemic NNS cord-019051-gtruu1op 500 8 typically typically RB cord-019051-gtruu1op 500 9 begin begin VBP cord-019051-gtruu1op 500 10 in in IN cord-019051-gtruu1op 500 11 the the DT cord-019051-gtruu1op 500 12 late late JJ cord-019051-gtruu1op 500 13 fall fall NN cord-019051-gtruu1op 500 14 with with IN cord-019051-gtruu1op 500 15 a a DT cord-019051-gtruu1op 500 16 peak peak NN cord-019051-gtruu1op 500 17 in in IN cord-019051-gtruu1op 500 18 late late JJ cord-019051-gtruu1op 500 19 winter winter NN cord-019051-gtruu1op 500 20 . . . cord-019051-gtruu1op 501 1 The the DT cord-019051-gtruu1op 501 2 seasonal seasonal JJ cord-019051-gtruu1op 501 3 pattern pattern NN cord-019051-gtruu1op 501 4 is be VBZ cord-019051-gtruu1op 501 5 less less RBR cord-019051-gtruu1op 501 6 pronounced pronounced JJ cord-019051-gtruu1op 501 7 in in IN cord-019051-gtruu1op 501 8 tropical tropical JJ cord-019051-gtruu1op 501 9 zones zone NNS cord-019051-gtruu1op 501 10 ( ( -LRB- cord-019051-gtruu1op 501 11 reviewed review VBN cord-019051-gtruu1op 501 12 in in IN cord-019051-gtruu1op 501 13 [ [ -LRB- cord-019051-gtruu1op 501 14 205 205 CD cord-019051-gtruu1op 501 15 ] ] -RRB- cord-019051-gtruu1op 501 16 ) ) -RRB- cord-019051-gtruu1op 501 17 . . . cord-019051-gtruu1op 502 1 The the DT cord-019051-gtruu1op 502 2 focus focus NN cord-019051-gtruu1op 502 3 of of IN cord-019051-gtruu1op 502 4 this this DT cord-019051-gtruu1op 502 5 book book NN cord-019051-gtruu1op 502 6 is be VBZ cord-019051-gtruu1op 502 7 on on IN cord-019051-gtruu1op 502 8 ' ' `` cord-019051-gtruu1op 502 9 common common JJ cord-019051-gtruu1op 502 10 cold cold NN cord-019051-gtruu1op 502 11 ' ' '' cord-019051-gtruu1op 502 12 . . . cord-019051-gtruu1op 503 1 For for IN cord-019051-gtruu1op 503 2 details detail NNS cord-019051-gtruu1op 503 3 on on IN cord-019051-gtruu1op 503 4 influenza influenza NN cord-019051-gtruu1op 503 5 and and CC cord-019051-gtruu1op 503 6 influenza influenza NN cord-019051-gtruu1op 503 7 viruses virus NNS cord-019051-gtruu1op 503 8 , , , cord-019051-gtruu1op 503 9 further further RB cord-019051-gtruu1op 503 10 reading reading NN cord-019051-gtruu1op 503 11 of of IN cord-019051-gtruu1op 503 12 standard standard JJ cord-019051-gtruu1op 503 13 literature literature NN cord-019051-gtruu1op 503 14 is be VBZ cord-019051-gtruu1op 503 15 recommended recommend VBN cord-019051-gtruu1op 503 16 . . . cord-019051-gtruu1op 504 1 Influenza influenza NN cord-019051-gtruu1op 504 2 viruses virus NNS cord-019051-gtruu1op 504 3 are be VBP cord-019051-gtruu1op 504 4 members member NNS cord-019051-gtruu1op 504 5 of of IN cord-019051-gtruu1op 504 6 the the DT cord-019051-gtruu1op 504 7 Orthomyxoviridae Orthomyxoviridae NNP cord-019051-gtruu1op 504 8 , , , cord-019051-gtruu1op 504 9 genus genus NN cord-019051-gtruu1op 504 10 Influenzavirus Influenzavirus NNP cord-019051-gtruu1op 504 11 and and CC cord-019051-gtruu1op 504 12 include include VB cord-019051-gtruu1op 504 13 influenza influenza NN cord-019051-gtruu1op 504 14 virus virus NN cord-019051-gtruu1op 504 15 types type VBZ cord-019051-gtruu1op 504 16 A A NNP cord-019051-gtruu1op 504 17 , , , cord-019051-gtruu1op 504 18 B b NN cord-019051-gtruu1op 504 19 and and CC cord-019051-gtruu1op 504 20 C. c. NN cord-019051-gtruu1op 505 1 The the DT cord-019051-gtruu1op 505 2 viruses virus NNS cord-019051-gtruu1op 505 3 are be VBP cord-019051-gtruu1op 505 4 enveloped envelop VBN cord-019051-gtruu1op 505 5 pleomorphic pleomorphic JJ cord-019051-gtruu1op 505 6 particles particle NNS cord-019051-gtruu1op 505 7 with with IN cord-019051-gtruu1op 505 8 a a DT cord-019051-gtruu1op 505 9 size size NN cord-019051-gtruu1op 505 10 ranging range VBG cord-019051-gtruu1op 505 11 from from IN cord-019051-gtruu1op 505 12 100 100 CD cord-019051-gtruu1op 505 13 to to IN cord-019051-gtruu1op 505 14 > > XX cord-019051-gtruu1op 505 15 300 300 CD cord-019051-gtruu1op 505 16 nm nm NN cord-019051-gtruu1op 505 17 , , , cord-019051-gtruu1op 505 18 their -PRON- PRP$ cord-019051-gtruu1op 505 19 genome genome NN cord-019051-gtruu1op 505 20 is be VBZ cord-019051-gtruu1op 505 21 organized organize VBN cord-019051-gtruu1op 505 22 on on IN cord-019051-gtruu1op 505 23 eight eight CD cord-019051-gtruu1op 505 24 ( ( -LRB- cord-019051-gtruu1op 505 25 influenza influenza NN cord-019051-gtruu1op 505 26 virus virus NN cord-019051-gtruu1op 505 27 A a NN cord-019051-gtruu1op 505 28 and and CC cord-019051-gtruu1op 505 29 B b NN cord-019051-gtruu1op 505 30 ) ) -RRB- cord-019051-gtruu1op 505 31 or or CC cord-019051-gtruu1op 505 32 seven seven CD cord-019051-gtruu1op 505 33 ( ( -LRB- cord-019051-gtruu1op 505 34 influenza influenza NN cord-019051-gtruu1op 505 35 virus virus NN cord-019051-gtruu1op 505 36 C C NNP cord-019051-gtruu1op 505 37 ) ) -RRB- cord-019051-gtruu1op 505 38 negative negative JJ cord-019051-gtruu1op 505 39 - - HYPH cord-019051-gtruu1op 505 40 sense sense NN cord-019051-gtruu1op 505 41 single single JJ cord-019051-gtruu1op 505 42 - - HYPH cord-019051-gtruu1op 505 43 stranded strand VBN cord-019051-gtruu1op 505 44 RNA rna NN cord-019051-gtruu1op 505 45 segments segment NNS cord-019051-gtruu1op 505 46 [ [ -LRB- cord-019051-gtruu1op 505 47 206 206 CD cord-019051-gtruu1op 505 48 ] ] -RRB- cord-019051-gtruu1op 505 49 . . . cord-019051-gtruu1op 506 1 Spikes spike NNS cord-019051-gtruu1op 506 2 consist consist VBP cord-019051-gtruu1op 506 3 of of IN cord-019051-gtruu1op 506 4 hemagglutinin hemagglutinin NN cord-019051-gtruu1op 506 5 ( ( -LRB- cord-019051-gtruu1op 506 6 HA HA NNP cord-019051-gtruu1op 506 7 ) ) -RRB- cord-019051-gtruu1op 506 8 and and CC cord-019051-gtruu1op 506 9 neuraminidase neuraminidase NN cord-019051-gtruu1op 506 10 ( ( -LRB- cord-019051-gtruu1op 506 11 NA NA NNP cord-019051-gtruu1op 506 12 ) ) -RRB- cord-019051-gtruu1op 506 13 . . . cord-019051-gtruu1op 507 1 The the DT cord-019051-gtruu1op 507 2 nomenclature nomenclature NN cord-019051-gtruu1op 507 3 for for IN cord-019051-gtruu1op 507 4 human human JJ cord-019051-gtruu1op 507 5 influenza influenza NN cord-019051-gtruu1op 507 6 virus virus NN cord-019051-gtruu1op 507 7 includes include VBZ cord-019051-gtruu1op 507 8 type type NN cord-019051-gtruu1op 507 9 , , , cord-019051-gtruu1op 507 10 geographic geographic JJ cord-019051-gtruu1op 507 11 location location NN cord-019051-gtruu1op 507 12 of of IN cord-019051-gtruu1op 507 13 the the DT cord-019051-gtruu1op 507 14 first first JJ cord-019051-gtruu1op 507 15 isolation isolation NN cord-019051-gtruu1op 507 16 , , , cord-019051-gtruu1op 507 17 isolate isolate VB cord-019051-gtruu1op 507 18 number number NN cord-019051-gtruu1op 507 19 and and CC cord-019051-gtruu1op 507 20 year year NN cord-019051-gtruu1op 507 21 of of IN cord-019051-gtruu1op 507 22 isolation isolation NN cord-019051-gtruu1op 507 23 . . . cord-019051-gtruu1op 508 1 In in IN cord-019051-gtruu1op 508 2 addition addition NN cord-019051-gtruu1op 508 3 , , , cord-019051-gtruu1op 508 4 subtypes subtype NNS cord-019051-gtruu1op 508 5 of of IN cord-019051-gtruu1op 508 6 influenza influenza NN cord-019051-gtruu1op 508 7 A A NNP cord-019051-gtruu1op 508 8 are be VBP cord-019051-gtruu1op 508 9 described describe VBN cord-019051-gtruu1op 508 10 by by IN cord-019051-gtruu1op 508 11 their -PRON- PRP$ cord-019051-gtruu1op 508 12 HA HA NNP cord-019051-gtruu1op 508 13 and and CC cord-019051-gtruu1op 508 14 NA NA NNP cord-019051-gtruu1op 508 15 designations designation NNS cord-019051-gtruu1op 508 16 . . . cord-019051-gtruu1op 509 1 To to IN cord-019051-gtruu1op 509 2 date date NN cord-019051-gtruu1op 509 3 , , , cord-019051-gtruu1op 509 4 16 16 CD cord-019051-gtruu1op 509 5 HA HA NNP cord-019051-gtruu1op 509 6 and and CC cord-019051-gtruu1op 509 7 9 9 CD cord-019051-gtruu1op 509 8 NA NA NNP cord-019051-gtruu1op 509 9 types type NNS cord-019051-gtruu1op 509 10 have have VBP cord-019051-gtruu1op 509 11 been be VBN cord-019051-gtruu1op 509 12 described describe VBN cord-019051-gtruu1op 509 13 . . . cord-019051-gtruu1op 510 1 The the DT cord-019051-gtruu1op 510 2 viral viral JJ cord-019051-gtruu1op 510 3 envelope envelope NN cord-019051-gtruu1op 510 4 is be VBZ cord-019051-gtruu1op 510 5 also also RB cord-019051-gtruu1op 510 6 associated associate VBN cord-019051-gtruu1op 510 7 with with IN cord-019051-gtruu1op 510 8 a a DT cord-019051-gtruu1op 510 9 matrix matrix NN cord-019051-gtruu1op 510 10 protein protein NN cord-019051-gtruu1op 510 11 ( ( -LRB- cord-019051-gtruu1op 510 12 M M NNP cord-019051-gtruu1op 510 13 ) ) -RRB- cord-019051-gtruu1op 510 14 that that IN cord-019051-gtruu1op 510 15 , , , cord-019051-gtruu1op 510 16 after after IN cord-019051-gtruu1op 510 17 infection infection NN cord-019051-gtruu1op 510 18 , , , cord-019051-gtruu1op 510 19 forms form VBZ cord-019051-gtruu1op 510 20 a a DT cord-019051-gtruu1op 510 21 tetrameric tetrameric JJ cord-019051-gtruu1op 510 22 ion ion NN cord-019051-gtruu1op 510 23 channel channel NN cord-019051-gtruu1op 510 24 . . . cord-019051-gtruu1op 511 1 Several several JJ cord-019051-gtruu1op 511 2 polymerase polymerase NN cord-019051-gtruu1op 511 3 proteins protein NNS cord-019051-gtruu1op 511 4 ( ( -LRB- cord-019051-gtruu1op 511 5 PB1 PB1 NNP cord-019051-gtruu1op 511 6 , , , cord-019051-gtruu1op 511 7 PB2 PB2 NNP cord-019051-gtruu1op 511 8 , , , cord-019051-gtruu1op 511 9 PA PA NNP cord-019051-gtruu1op 511 10 ) ) -RRB- cord-019051-gtruu1op 511 11 form form NN cord-019051-gtruu1op 511 12 , , , cord-019051-gtruu1op 511 13 together together RB cord-019051-gtruu1op 511 14 with with IN cord-019051-gtruu1op 511 15 the the DT cord-019051-gtruu1op 511 16 nucleoprotein nucleoprotein NNP cord-019051-gtruu1op 511 17 ( ( -LRB- cord-019051-gtruu1op 511 18 NP NP NNP cord-019051-gtruu1op 511 19 ) ) -RRB- cord-019051-gtruu1op 511 20 and and CC cord-019051-gtruu1op 511 21 the the DT cord-019051-gtruu1op 511 22 RNA RNA NNP cord-019051-gtruu1op 511 23 , , , cord-019051-gtruu1op 511 24 a a DT cord-019051-gtruu1op 511 25 ribonucleoprotein ribonucleoprotein NN cord-019051-gtruu1op 511 26 ( ( -LRB- cord-019051-gtruu1op 511 27 RNP RNP NNP cord-019051-gtruu1op 511 28 ) ) -RRB- cord-019051-gtruu1op 511 29 complex complex NNP cord-019051-gtruu1op 511 30 ( ( -LRB- cord-019051-gtruu1op 511 31 reviewed review VBN cord-019051-gtruu1op 511 32 in in IN cord-019051-gtruu1op 511 33 [ [ -LRB- cord-019051-gtruu1op 511 34 206 206 CD cord-019051-gtruu1op 511 35 ] ] -RRB- cord-019051-gtruu1op 511 36 ) ) -RRB- cord-019051-gtruu1op 511 37 . . . cord-019051-gtruu1op 512 1 Influenza influenza NN cord-019051-gtruu1op 512 2 viruses virus NNS cord-019051-gtruu1op 512 3 are be VBP cord-019051-gtruu1op 512 4 transmitted transmit VBN cord-019051-gtruu1op 512 5 via via IN cord-019051-gtruu1op 512 6 the the DT cord-019051-gtruu1op 512 7 respiratory respiratory JJ cord-019051-gtruu1op 512 8 route route NN cord-019051-gtruu1op 512 9 and and CC cord-019051-gtruu1op 512 10 bind bind VB cord-019051-gtruu1op 512 11 to to IN cord-019051-gtruu1op 512 12 a a DT cord-019051-gtruu1op 512 13 cell cell NN cord-019051-gtruu1op 512 14 receptor receptor NN cord-019051-gtruu1op 512 15 that that WDT cord-019051-gtruu1op 512 16 consists consist VBZ cord-019051-gtruu1op 512 17 of of IN cord-019051-gtruu1op 512 18 oligosaccharides oligosaccharide NNS cord-019051-gtruu1op 512 19 and and CC cord-019051-gtruu1op 512 20 that that DT cord-019051-gtruu1op 512 21 is be VBZ cord-019051-gtruu1op 512 22 present present JJ cord-019051-gtruu1op 512 23 on on IN cord-019051-gtruu1op 512 24 the the DT cord-019051-gtruu1op 512 25 surface surface NN cord-019051-gtruu1op 512 26 of of IN cord-019051-gtruu1op 512 27 respiratory respiratory JJ cord-019051-gtruu1op 512 28 epithelial epithelial JJ cord-019051-gtruu1op 512 29 cells cell NNS cord-019051-gtruu1op 512 30 . . . cord-019051-gtruu1op 513 1 The the DT cord-019051-gtruu1op 513 2 sialic sialic NN cord-019051-gtruu1op 513 3 acid-2,6-galactose acid-2,6-galactose JJ cord-019051-gtruu1op 513 4 linkage linkage NN cord-019051-gtruu1op 513 5 ( ( -LRB- cord-019051-gtruu1op 513 6 SA SA NNP cord-019051-gtruu1op 513 7 2,6Gal 2,6gal CD cord-019051-gtruu1op 513 8 ) ) -RRB- cord-019051-gtruu1op 513 9 that that WDT cord-019051-gtruu1op 513 10 is be VBZ cord-019051-gtruu1op 513 11 associated associate VBN cord-019051-gtruu1op 513 12 with with IN cord-019051-gtruu1op 513 13 binding bind VBG cord-019051-gtruu1op 513 14 to to IN cord-019051-gtruu1op 513 15 human human JJ cord-019051-gtruu1op 513 16 influenza influenza NN cord-019051-gtruu1op 513 17 virus virus NN cord-019051-gtruu1op 514 1 HA HA NNP cord-019051-gtruu1op 514 2 is be VBZ cord-019051-gtruu1op 514 3 present present JJ cord-019051-gtruu1op 514 4 in in IN cord-019051-gtruu1op 514 5 the the DT cord-019051-gtruu1op 514 6 human human JJ cord-019051-gtruu1op 514 7 respiratory respiratory JJ cord-019051-gtruu1op 514 8 tract tract NN cord-019051-gtruu1op 514 9 ( ( -LRB- cord-019051-gtruu1op 514 10 reviewed review VBN cord-019051-gtruu1op 514 11 in in IN cord-019051-gtruu1op 514 12 [ [ -LRB- cord-019051-gtruu1op 514 13 207 207 CD cord-019051-gtruu1op 514 14 ] ] -RRB- cord-019051-gtruu1op 514 15 ) ) -RRB- cord-019051-gtruu1op 514 16 . . . cord-019051-gtruu1op 515 1 After after IN cord-019051-gtruu1op 515 2 binding bind VBG cord-019051-gtruu1op 515 3 , , , cord-019051-gtruu1op 515 4 the the DT cord-019051-gtruu1op 515 5 virus virus NN cord-019051-gtruu1op 515 6 enters enter VBZ cord-019051-gtruu1op 515 7 the the DT cord-019051-gtruu1op 515 8 host host NN cord-019051-gtruu1op 515 9 cell cell NN cord-019051-gtruu1op 515 10 by by IN cord-019051-gtruu1op 515 11 endocytosis endocytosis NN cord-019051-gtruu1op 515 12 [ [ -LRB- cord-019051-gtruu1op 515 13 208 208 CD cord-019051-gtruu1op 515 14 ] ] -RRB- cord-019051-gtruu1op 515 15 . . . cord-019051-gtruu1op 516 1 Further further JJ cord-019051-gtruu1op 516 2 steps step NNS cord-019051-gtruu1op 516 3 include include VBP cord-019051-gtruu1op 516 4 fusion fusion NN cord-019051-gtruu1op 516 5 of of IN cord-019051-gtruu1op 516 6 the the DT cord-019051-gtruu1op 516 7 virus virus NN cord-019051-gtruu1op 516 8 to to IN cord-019051-gtruu1op 516 9 the the DT cord-019051-gtruu1op 516 10 endosome endosome NN cord-019051-gtruu1op 516 11 [ [ -LRB- cord-019051-gtruu1op 516 12 206 206 CD cord-019051-gtruu1op 516 13 ] ] -RRB- cord-019051-gtruu1op 516 14 and and CC cord-019051-gtruu1op 516 15 the the DT cord-019051-gtruu1op 516 16 release release NN cord-019051-gtruu1op 516 17 of of IN cord-019051-gtruu1op 516 18 the the DT cord-019051-gtruu1op 516 19 RNP RNP NNP cord-019051-gtruu1op 516 20 into into IN cord-019051-gtruu1op 516 21 the the DT cord-019051-gtruu1op 516 22 nucleus nucleus NN cord-019051-gtruu1op 516 23 through through IN cord-019051-gtruu1op 516 24 an an DT cord-019051-gtruu1op 516 25 ion ion NN cord-019051-gtruu1op 516 26 channel channel NN cord-019051-gtruu1op 516 27 that that WDT cord-019051-gtruu1op 516 28 is be VBZ cord-019051-gtruu1op 516 29 formed form VBN cord-019051-gtruu1op 516 30 by by IN cord-019051-gtruu1op 516 31 M2 M2 NNP cord-019051-gtruu1op 516 32 [ [ -LRB- cord-019051-gtruu1op 516 33 209 209 CD cord-019051-gtruu1op 516 34 ] ] -RRB- cord-019051-gtruu1op 516 35 . . . cord-019051-gtruu1op 517 1 The the DT cord-019051-gtruu1op 517 2 viral viral JJ cord-019051-gtruu1op 517 3 RNA RNA NNP cord-019051-gtruu1op 517 4 is be VBZ cord-019051-gtruu1op 517 5 a a DT cord-019051-gtruu1op 517 6 template template NN cord-019051-gtruu1op 517 7 for for IN cord-019051-gtruu1op 517 8 complementary complementary JJ cord-019051-gtruu1op 517 9 RNA RNA NNP cord-019051-gtruu1op 517 10 and and CC cord-019051-gtruu1op 517 11 the the DT cord-019051-gtruu1op 517 12 mRNA mrna NN cord-019051-gtruu1op 517 13 . . . cord-019051-gtruu1op 518 1 The the DT cord-019051-gtruu1op 518 2 nonstructural nonstructural JJ cord-019051-gtruu1op 518 3 NEP NEP NNP cord-019051-gtruu1op 518 4 / / SYM cord-019051-gtruu1op 518 5 NS2 NS2 NNP cord-019051-gtruu1op 518 6 as as RB cord-019051-gtruu1op 518 7 well well RB cord-019051-gtruu1op 518 8 as as IN cord-019051-gtruu1op 518 9 M1 M1 NNP cord-019051-gtruu1op 518 10 play play VBP cord-019051-gtruu1op 518 11 a a DT cord-019051-gtruu1op 518 12 role role NN cord-019051-gtruu1op 518 13 in in IN cord-019051-gtruu1op 518 14 the the DT cord-019051-gtruu1op 518 15 nuclear nuclear JJ cord-019051-gtruu1op 518 16 export export NN cord-019051-gtruu1op 518 17 of of IN cord-019051-gtruu1op 518 18 novel novel NN cord-019051-gtruu1op 518 19 RNA RNA NNP cord-019051-gtruu1op 518 20 . . . cord-019051-gtruu1op 519 1 Assembly assembly NN cord-019051-gtruu1op 519 2 occurs occur VBZ cord-019051-gtruu1op 519 3 at at IN cord-019051-gtruu1op 519 4 the the DT cord-019051-gtruu1op 519 5 apical apical JJ cord-019051-gtruu1op 519 6 surface surface NN cord-019051-gtruu1op 519 7 of of IN cord-019051-gtruu1op 519 8 the the DT cord-019051-gtruu1op 519 9 cell cell NN cord-019051-gtruu1op 519 10 , , , cord-019051-gtruu1op 519 11 budding budding NN cord-019051-gtruu1op 519 12 occurs occur VBZ cord-019051-gtruu1op 519 13 and and CC cord-019051-gtruu1op 519 14 the the DT cord-019051-gtruu1op 519 15 novel novel JJ cord-019051-gtruu1op 519 16 virus virus NN cord-019051-gtruu1op 519 17 is be VBZ cord-019051-gtruu1op 519 18 released release VBN cord-019051-gtruu1op 519 19 ( ( -LRB- cord-019051-gtruu1op 519 20 reviewed review VBN cord-019051-gtruu1op 519 21 in in IN cord-019051-gtruu1op 519 22 [ [ -LRB- cord-019051-gtruu1op 519 23 206 206 CD cord-019051-gtruu1op 519 24 ] ] -RRB- cord-019051-gtruu1op 519 25 ) ) -RRB- cord-019051-gtruu1op 519 26 . . . cord-019051-gtruu1op 520 1 Influenza influenza NN cord-019051-gtruu1op 520 2 viruses virus NNS cord-019051-gtruu1op 520 3 are be VBP cord-019051-gtruu1op 520 4 transmitted transmit VBN cord-019051-gtruu1op 520 5 via via IN cord-019051-gtruu1op 520 6 the the DT cord-019051-gtruu1op 520 7 respiratory respiratory JJ cord-019051-gtruu1op 520 8 route route NN cord-019051-gtruu1op 520 9 [ [ -LRB- cord-019051-gtruu1op 520 10 206 206 CD cord-019051-gtruu1op 520 11 ] ] -RRB- cord-019051-gtruu1op 520 12 . . . cord-019051-gtruu1op 521 1 Host host NN cord-019051-gtruu1op 521 2 specificity specificity NN cord-019051-gtruu1op 521 3 is be VBZ cord-019051-gtruu1op 521 4 largely largely RB cord-019051-gtruu1op 521 5 determined determine VBN cord-019051-gtruu1op 521 6 by by IN cord-019051-gtruu1op 521 7 the the DT cord-019051-gtruu1op 521 8 availability availability NN cord-019051-gtruu1op 521 9 of of IN cord-019051-gtruu1op 521 10 host host NN cord-019051-gtruu1op 521 11 cell cell NN cord-019051-gtruu1op 521 12 receptors receptor NNS cord-019051-gtruu1op 521 13 on on IN cord-019051-gtruu1op 521 14 the the DT cord-019051-gtruu1op 521 15 surface surface NN cord-019051-gtruu1op 521 16 of of IN cord-019051-gtruu1op 521 17 epithelial epithelial JJ cord-019051-gtruu1op 521 18 cells cell NNS cord-019051-gtruu1op 521 19 [ [ -LRB- cord-019051-gtruu1op 521 20 210 210 CD cord-019051-gtruu1op 521 21 ] ] -RRB- cord-019051-gtruu1op 521 22 . . . cord-019051-gtruu1op 522 1 Usually usually RB cord-019051-gtruu1op 522 2 , , , cord-019051-gtruu1op 522 3 influenza influenza NN cord-019051-gtruu1op 522 4 in in IN cord-019051-gtruu1op 522 5 humans human NNS cord-019051-gtruu1op 522 6 is be VBZ cord-019051-gtruu1op 522 7 an an DT cord-019051-gtruu1op 522 8 URTI URTI NNP cord-019051-gtruu1op 522 9 that that WDT cord-019051-gtruu1op 522 10 is be VBZ cord-019051-gtruu1op 522 11 characterized characterize VBN cord-019051-gtruu1op 522 12 by by IN cord-019051-gtruu1op 522 13 cough cough NN cord-019051-gtruu1op 522 14 , , , cord-019051-gtruu1op 522 15 headache headache NN cord-019051-gtruu1op 522 16 , , , cord-019051-gtruu1op 522 17 malaise malaise NN cord-019051-gtruu1op 522 18 and and CC cord-019051-gtruu1op 522 19 fever fever NN cord-019051-gtruu1op 522 20 [ [ -LRB- cord-019051-gtruu1op 522 21 211 211 CD cord-019051-gtruu1op 522 22 ] ] -RRB- cord-019051-gtruu1op 522 23 . . . cord-019051-gtruu1op 523 1 However however RB cord-019051-gtruu1op 523 2 , , , cord-019051-gtruu1op 523 3 complications complication NNS cord-019051-gtruu1op 523 4 are be VBP cord-019051-gtruu1op 523 5 frequent frequent JJ cord-019051-gtruu1op 523 6 , , , cord-019051-gtruu1op 523 7 and and CC cord-019051-gtruu1op 523 8 encephalitis encephalitis RB cord-019051-gtruu1op 523 9 , , , cord-019051-gtruu1op 523 10 Reye Reye NNP cord-019051-gtruu1op 523 11 's 's POS cord-019051-gtruu1op 523 12 syndrome syndrome NN cord-019051-gtruu1op 523 13 , , , cord-019051-gtruu1op 523 14 myelitis myelitis NNP cord-019051-gtruu1op 523 15 [ [ -LRB- cord-019051-gtruu1op 523 16 212 212 CD cord-019051-gtruu1op 523 17 ] ] -RRB- cord-019051-gtruu1op 523 18 as as RB cord-019051-gtruu1op 523 19 well well RB cord-019051-gtruu1op 523 20 as as IN cord-019051-gtruu1op 523 21 muscular muscular JJ cord-019051-gtruu1op 523 22 manifestations manifestation NNS cord-019051-gtruu1op 523 23 of of IN cord-019051-gtruu1op 523 24 the the DT cord-019051-gtruu1op 523 25 infection infection NN cord-019051-gtruu1op 523 26 including include VBG cord-019051-gtruu1op 523 27 myocarditis myocarditis NN cord-019051-gtruu1op 523 28 [ [ -LRB- cord-019051-gtruu1op 523 29 213 213 CD cord-019051-gtruu1op 523 30 ] ] -RRB- cord-019051-gtruu1op 523 31 , , , cord-019051-gtruu1op 523 32 disseminated disseminate VBN cord-019051-gtruu1op 523 33 intravascular intravascular JJ cord-019051-gtruu1op 523 34 coagulation coagulation NN cord-019051-gtruu1op 523 35 and and CC cord-019051-gtruu1op 523 36 toxic toxic JJ cord-019051-gtruu1op 523 37 and and CC cord-019051-gtruu1op 523 38 septic septic JJ cord-019051-gtruu1op 523 39 shock shock NN cord-019051-gtruu1op 523 40 [ [ -LRB- cord-019051-gtruu1op 523 41 214 214 CD cord-019051-gtruu1op 523 42 ] ] -RRB- cord-019051-gtruu1op 523 43 may may MD cord-019051-gtruu1op 523 44 occur occur VB cord-019051-gtruu1op 523 45 . . . cord-019051-gtruu1op 524 1 Major major JJ cord-019051-gtruu1op 524 2 airway airway NN cord-019051-gtruu1op 524 3 congestion congestion NN cord-019051-gtruu1op 524 4 , , , cord-019051-gtruu1op 524 5 inflammation inflammation NN cord-019051-gtruu1op 524 6 and and CC cord-019051-gtruu1op 524 7 necrosis necrosis NN cord-019051-gtruu1op 524 8 have have VBP cord-019051-gtruu1op 524 9 been be VBN cord-019051-gtruu1op 524 10 found find VBN cord-019051-gtruu1op 524 11 in in IN cord-019051-gtruu1op 524 12 histopathological histopathological JJ cord-019051-gtruu1op 524 13 examinations examination NNS cord-019051-gtruu1op 524 14 [ [ -LRB- cord-019051-gtruu1op 524 15 215 215 CD cord-019051-gtruu1op 524 16 ] ] -RRB- cord-019051-gtruu1op 524 17 . . . cord-019051-gtruu1op 525 1 Although although IN cord-019051-gtruu1op 525 2 much much JJ cord-019051-gtruu1op 525 3 progress progress NN cord-019051-gtruu1op 525 4 in in IN cord-019051-gtruu1op 525 5 the the DT cord-019051-gtruu1op 525 6 understanding understanding NN cord-019051-gtruu1op 525 7 of of IN cord-019051-gtruu1op 525 8 the the DT cord-019051-gtruu1op 525 9 pathogenesis pathogenesis NN cord-019051-gtruu1op 525 10 of of IN cord-019051-gtruu1op 525 11 human human JJ cord-019051-gtruu1op 525 12 influenza influenza NN cord-019051-gtruu1op 525 13 has have VBZ cord-019051-gtruu1op 525 14 been be VBN cord-019051-gtruu1op 525 15 made make VBN cord-019051-gtruu1op 525 16 during during IN cord-019051-gtruu1op 525 17 the the DT cord-019051-gtruu1op 525 18 past past JJ cord-019051-gtruu1op 525 19 decade decade NN cord-019051-gtruu1op 525 20 , , , cord-019051-gtruu1op 525 21 the the DT cord-019051-gtruu1op 525 22 molecular molecular JJ cord-019051-gtruu1op 525 23 mechanisms mechanism NNS cord-019051-gtruu1op 525 24 responsible responsible JJ cord-019051-gtruu1op 525 25 for for IN cord-019051-gtruu1op 525 26 the the DT cord-019051-gtruu1op 525 27 virulence virulence NN cord-019051-gtruu1op 525 28 of of IN cord-019051-gtruu1op 525 29 particular particular JJ cord-019051-gtruu1op 525 30 strains strain NNS cord-019051-gtruu1op 525 31 of of IN cord-019051-gtruu1op 525 32 influenza influenza NN cord-019051-gtruu1op 525 33 virus virus NN cord-019051-gtruu1op 525 34 are be VBP cord-019051-gtruu1op 525 35 not not RB cord-019051-gtruu1op 525 36 yet yet RB cord-019051-gtruu1op 525 37 understood understand VBN cord-019051-gtruu1op 525 38 . . . cord-019051-gtruu1op 526 1 Influenza Influenza NNP cord-019051-gtruu1op 526 2 A a DT cord-019051-gtruu1op 526 3 virus virus NN cord-019051-gtruu1op 526 4 can can MD cord-019051-gtruu1op 526 5 infect infect VB cord-019051-gtruu1op 526 6 humans human NNS cord-019051-gtruu1op 526 7 as as RB cord-019051-gtruu1op 526 8 well well RB cord-019051-gtruu1op 526 9 as as IN cord-019051-gtruu1op 526 10 waterfowl waterfowl NN cord-019051-gtruu1op 526 11 and and CC cord-019051-gtruu1op 526 12 chickens chicken NNS cord-019051-gtruu1op 526 13 , , , cord-019051-gtruu1op 526 14 swine swine NN cord-019051-gtruu1op 526 15 , , , cord-019051-gtruu1op 526 16 horses horse NNS cord-019051-gtruu1op 526 17 , , , cord-019051-gtruu1op 526 18 and and CC cord-019051-gtruu1op 526 19 other other JJ cord-019051-gtruu1op 526 20 species specie NNS cord-019051-gtruu1op 526 21 . . . cord-019051-gtruu1op 527 1 Influenza Influenza NNP cord-019051-gtruu1op 527 2 B B NNP cord-019051-gtruu1op 527 3 virus virus NN cord-019051-gtruu1op 527 4 , , , cord-019051-gtruu1op 527 5 on on IN cord-019051-gtruu1op 527 6 the the DT cord-019051-gtruu1op 527 7 other other JJ cord-019051-gtruu1op 527 8 hand hand NN cord-019051-gtruu1op 527 9 , , , cord-019051-gtruu1op 527 10 has have VBZ cord-019051-gtruu1op 527 11 a a DT cord-019051-gtruu1op 527 12 restricted restricted JJ cord-019051-gtruu1op 527 13 host host NN cord-019051-gtruu1op 527 14 range range NN cord-019051-gtruu1op 527 15 and and CC cord-019051-gtruu1op 527 16 circulates circulate VBZ cord-019051-gtruu1op 527 17 predominantly predominantly RB cord-019051-gtruu1op 527 18 in in IN cord-019051-gtruu1op 527 19 humans human NNS cord-019051-gtruu1op 527 20 . . . cord-019051-gtruu1op 528 1 However however RB cord-019051-gtruu1op 528 2 , , , cord-019051-gtruu1op 528 3 influenza influenza NN cord-019051-gtruu1op 528 4 B b NN cord-019051-gtruu1op 528 5 virus virus NN cord-019051-gtruu1op 528 6 was be VBD cord-019051-gtruu1op 528 7 recently recently RB cord-019051-gtruu1op 528 8 isolated isolate VBN cord-019051-gtruu1op 528 9 from from IN cord-019051-gtruu1op 528 10 seals seal NNS cord-019051-gtruu1op 528 11 [ [ -LRB- cord-019051-gtruu1op 528 12 216 216 CD cord-019051-gtruu1op 528 13 ] ] -RRB- cord-019051-gtruu1op 528 14 . . . cord-019051-gtruu1op 529 1 Different different JJ cord-019051-gtruu1op 529 2 types type NNS cord-019051-gtruu1op 529 3 of of IN cord-019051-gtruu1op 529 4 HA HA NNP cord-019051-gtruu1op 529 5 mediate mediate VB cord-019051-gtruu1op 529 6 species species NN cord-019051-gtruu1op 529 7 - - HYPH cord-019051-gtruu1op 529 8 specific specific JJ cord-019051-gtruu1op 529 9 binding binding NN cord-019051-gtruu1op 529 10 of of IN cord-019051-gtruu1op 529 11 the the DT cord-019051-gtruu1op 529 12 virus virus NN cord-019051-gtruu1op 529 13 [ [ -LRB- cord-019051-gtruu1op 529 14 217 217 CD cord-019051-gtruu1op 529 15 , , , cord-019051-gtruu1op 529 16 218 218 CD cord-019051-gtruu1op 529 17 ] ] -RRB- cord-019051-gtruu1op 529 18 . . . cord-019051-gtruu1op 530 1 It -PRON- PRP cord-019051-gtruu1op 530 2 would would MD cord-019051-gtruu1op 530 3 be be VB cord-019051-gtruu1op 530 4 beyond beyond IN cord-019051-gtruu1op 530 5 the the DT cord-019051-gtruu1op 530 6 scope scope NN cord-019051-gtruu1op 530 7 of of IN cord-019051-gtruu1op 530 8 this this DT cord-019051-gtruu1op 530 9 book book NN cord-019051-gtruu1op 530 10 on on IN cord-019051-gtruu1op 530 11 common common JJ cord-019051-gtruu1op 530 12 cold cold NN cord-019051-gtruu1op 530 13 to to TO cord-019051-gtruu1op 530 14 review review VB cord-019051-gtruu1op 530 15 all all PDT cord-019051-gtruu1op 530 16 the the DT cord-019051-gtruu1op 530 17 recent recent JJ cord-019051-gtruu1op 530 18 literature literature NN cord-019051-gtruu1op 530 19 that that WDT cord-019051-gtruu1op 530 20 has have VBZ cord-019051-gtruu1op 530 21 been be VBN cord-019051-gtruu1op 530 22 published publish VBN cord-019051-gtruu1op 530 23 regarding regard VBG cord-019051-gtruu1op 530 24 the the DT cord-019051-gtruu1op 530 25 epidemiology epidemiology NN cord-019051-gtruu1op 530 26 of of IN cord-019051-gtruu1op 530 27 influenza influenza NN cord-019051-gtruu1op 530 28 viruses virus NNS cord-019051-gtruu1op 530 29 . . . cord-019051-gtruu1op 531 1 However however RB cord-019051-gtruu1op 531 2 , , , cord-019051-gtruu1op 531 3 one one CD cord-019051-gtruu1op 531 4 important important JJ cord-019051-gtruu1op 531 5 aspect aspect NN cord-019051-gtruu1op 531 6 should should MD cord-019051-gtruu1op 531 7 be be VB cord-019051-gtruu1op 531 8 mentioned mention VBN cord-019051-gtruu1op 531 9 here here RB cord-019051-gtruu1op 531 10 . . . cord-019051-gtruu1op 532 1 Influenza influenza NN cord-019051-gtruu1op 532 2 virus virus NN cord-019051-gtruu1op 532 3 is be VBZ cord-019051-gtruu1op 532 4 a a DT cord-019051-gtruu1op 532 5 changing change VBG cord-019051-gtruu1op 532 6 virus virus NN cord-019051-gtruu1op 532 7 and and CC cord-019051-gtruu1op 532 8 the the DT cord-019051-gtruu1op 532 9 repetitive repetitive JJ cord-019051-gtruu1op 532 10 occurrence occurrence NN cord-019051-gtruu1op 532 11 of of IN cord-019051-gtruu1op 532 12 the the DT cord-019051-gtruu1op 532 13 yearly yearly JJ cord-019051-gtruu1op 532 14 epidemic epidemic NN cord-019051-gtruu1op 532 15 is be VBZ cord-019051-gtruu1op 532 16 supported support VBN cord-019051-gtruu1op 532 17 by by IN cord-019051-gtruu1op 532 18 ' ' `` cord-019051-gtruu1op 532 19 antigenic antigenic JJ cord-019051-gtruu1op 532 20 drift drift NN cord-019051-gtruu1op 532 21 ' ' '' cord-019051-gtruu1op 532 22 , , , cord-019051-gtruu1op 532 23 an an DT cord-019051-gtruu1op 532 24 accumulation accumulation NN cord-019051-gtruu1op 532 25 of of IN cord-019051-gtruu1op 532 26 point point NN cord-019051-gtruu1op 532 27 mutations mutation NNS cord-019051-gtruu1op 532 28 in in IN cord-019051-gtruu1op 532 29 the the DT cord-019051-gtruu1op 532 30 viral viral JJ cord-019051-gtruu1op 532 31 receptors receptor NNS cord-019051-gtruu1op 532 32 ( ( -LRB- cord-019051-gtruu1op 532 33 HA HA NNP cord-019051-gtruu1op 532 34 and and CC cord-019051-gtruu1op 532 35 NA NA NNP cord-019051-gtruu1op 532 36 ) ) -RRB- cord-019051-gtruu1op 532 37 . . . cord-019051-gtruu1op 533 1 The the DT cord-019051-gtruu1op 533 2 drift drift NN cord-019051-gtruu1op 533 3 is be VBZ cord-019051-gtruu1op 533 4 attributed attribute VBN cord-019051-gtruu1op 533 5 to to IN cord-019051-gtruu1op 533 6 a a DT cord-019051-gtruu1op 533 7 low low JJ cord-019051-gtruu1op 533 8 fidelity fidelity NN cord-019051-gtruu1op 533 9 of of IN cord-019051-gtruu1op 533 10 the the DT cord-019051-gtruu1op 533 11 viral viral JJ cord-019051-gtruu1op 533 12 RNA RNA NNP cord-019051-gtruu1op 533 13 polymerase polymerase NN cord-019051-gtruu1op 533 14 [ [ -LRB- cord-019051-gtruu1op 533 15 219 219 CD cord-019051-gtruu1op 533 16 ] ] -RRB- cord-019051-gtruu1op 533 17 . . . cord-019051-gtruu1op 534 1 These these DT cord-019051-gtruu1op 534 2 new new JJ cord-019051-gtruu1op 534 3 variants variant NNS cord-019051-gtruu1op 534 4 then then RB cord-019051-gtruu1op 534 5 infect infect VBP cord-019051-gtruu1op 534 6 a a DT cord-019051-gtruu1op 534 7 population population NN cord-019051-gtruu1op 534 8 without without IN cord-019051-gtruu1op 534 9 pre pre JJ cord-019051-gtruu1op 534 10 - - JJ cord-019051-gtruu1op 534 11 existing existing JJ cord-019051-gtruu1op 534 12 immunity immunity NN cord-019051-gtruu1op 534 13 ( ( -LRB- cord-019051-gtruu1op 534 14 reviewed review VBN cord-019051-gtruu1op 534 15 in in IN cord-019051-gtruu1op 534 16 [ [ -LRB- cord-019051-gtruu1op 534 17 206 206 CD cord-019051-gtruu1op 534 18 ] ] -RRB- cord-019051-gtruu1op 534 19 ) ) -RRB- cord-019051-gtruu1op 534 20 . . . cord-019051-gtruu1op 535 1 A a DT cord-019051-gtruu1op 535 2 second second JJ cord-019051-gtruu1op 535 3 process process NN cord-019051-gtruu1op 535 4 that that WDT cord-019051-gtruu1op 535 5 contributes contribute VBZ cord-019051-gtruu1op 535 6 to to IN cord-019051-gtruu1op 535 7 the the DT cord-019051-gtruu1op 535 8 emergence emergence NN cord-019051-gtruu1op 535 9 of of IN cord-019051-gtruu1op 535 10 new new JJ cord-019051-gtruu1op 535 11 influenza influenza NN cord-019051-gtruu1op 535 12 variants variant NNS cord-019051-gtruu1op 535 13 is be VBZ cord-019051-gtruu1op 535 14 called call VBN cord-019051-gtruu1op 535 15 ' ' `` cord-019051-gtruu1op 535 16 antigenic antigenic JJ cord-019051-gtruu1op 535 17 shift shift NN cord-019051-gtruu1op 535 18 ' ' '' cord-019051-gtruu1op 535 19 . . . cord-019051-gtruu1op 536 1 An an DT cord-019051-gtruu1op 536 2 antigenic antigenic JJ cord-019051-gtruu1op 536 3 shift shift NN cord-019051-gtruu1op 536 4 may may MD cord-019051-gtruu1op 536 5 occur occur VB cord-019051-gtruu1op 536 6 during during IN cord-019051-gtruu1op 536 7 co co NN cord-019051-gtruu1op 536 8 - - NN cord-019051-gtruu1op 536 9 infection infection NN cord-019051-gtruu1op 536 10 with with IN cord-019051-gtruu1op 536 11 other other JJ cord-019051-gtruu1op 536 12 influenza influenza NN cord-019051-gtruu1op 536 13 viruses virus NNS cord-019051-gtruu1op 536 14 . . . cord-019051-gtruu1op 537 1 Such such JJ cord-019051-gtruu1op 537 2 a a DT cord-019051-gtruu1op 537 3 co co NN cord-019051-gtruu1op 537 4 - - NN cord-019051-gtruu1op 537 5 infection infection NN cord-019051-gtruu1op 537 6 may may MD cord-019051-gtruu1op 537 7 lead lead VB cord-019051-gtruu1op 537 8 to to IN cord-019051-gtruu1op 537 9 a a DT cord-019051-gtruu1op 537 10 viral viral JJ cord-019051-gtruu1op 537 11 reassortment reassortment NN cord-019051-gtruu1op 537 12 ( ( -LRB- cord-019051-gtruu1op 537 13 an an DT cord-019051-gtruu1op 537 14 exchange exchange NN cord-019051-gtruu1op 537 15 of of IN cord-019051-gtruu1op 537 16 genome genome NN cord-019051-gtruu1op 537 17 segments segment NNS cord-019051-gtruu1op 537 18 between between IN cord-019051-gtruu1op 537 19 different different JJ cord-019051-gtruu1op 537 20 virus virus NN cord-019051-gtruu1op 537 21 strains strain NNS cord-019051-gtruu1op 537 22 ) ) -RRB- cord-019051-gtruu1op 537 23 [ [ -LRB- cord-019051-gtruu1op 537 24 206 206 CD cord-019051-gtruu1op 537 25 ] ] -RRB- cord-019051-gtruu1op 537 26 . . . cord-019051-gtruu1op 538 1 If if IN cord-019051-gtruu1op 538 2 this this DT cord-019051-gtruu1op 538 3 process process NN cord-019051-gtruu1op 538 4 leads lead VBZ cord-019051-gtruu1op 538 5 to to IN cord-019051-gtruu1op 538 6 a a DT cord-019051-gtruu1op 538 7 new new JJ cord-019051-gtruu1op 538 8 virus virus NN cord-019051-gtruu1op 538 9 strain strain NN cord-019051-gtruu1op 538 10 that that WDT cord-019051-gtruu1op 538 11 is be VBZ cord-019051-gtruu1op 538 12 able able JJ cord-019051-gtruu1op 538 13 to to TO cord-019051-gtruu1op 538 14 effectively effectively RB cord-019051-gtruu1op 538 15 spread spread VB cord-019051-gtruu1op 538 16 from from IN cord-019051-gtruu1op 538 17 individual individual JJ cord-019051-gtruu1op 538 18 to to IN cord-019051-gtruu1op 538 19 individual individual NN cord-019051-gtruu1op 538 20 , , , cord-019051-gtruu1op 538 21 a a DT cord-019051-gtruu1op 538 22 worldwide worldwide JJ cord-019051-gtruu1op 538 23 outbreak outbreak NN cord-019051-gtruu1op 538 24 , , , cord-019051-gtruu1op 538 25 a a DT cord-019051-gtruu1op 538 26 pandemic pandemic NN cord-019051-gtruu1op 538 27 , , , cord-019051-gtruu1op 538 28 may may MD cord-019051-gtruu1op 538 29 occur occur VB cord-019051-gtruu1op 538 30 [ [ -LRB- cord-019051-gtruu1op 538 31 207 207 CD cord-019051-gtruu1op 538 32 ] ] -RRB- cord-019051-gtruu1op 538 33 . . . cord-019051-gtruu1op 539 1 There there EX cord-019051-gtruu1op 539 2 have have VBP cord-019051-gtruu1op 539 3 been be VBN cord-019051-gtruu1op 539 4 several several JJ cord-019051-gtruu1op 539 5 pandemics pandemic NNS cord-019051-gtruu1op 539 6 in in IN cord-019051-gtruu1op 539 7 the the DT cord-019051-gtruu1op 539 8 past past JJ cord-019051-gtruu1op 539 9 century century NN cord-019051-gtruu1op 539 10 including include VBG cord-019051-gtruu1op 539 11 the the DT cord-019051-gtruu1op 539 12 so so RB cord-019051-gtruu1op 539 13 - - HYPH cord-019051-gtruu1op 539 14 called call VBN cord-019051-gtruu1op 539 15 " " `` cord-019051-gtruu1op 539 16 Spanish spanish JJ cord-019051-gtruu1op 539 17 flu flu NN cord-019051-gtruu1op 539 18 " " '' cord-019051-gtruu1op 539 19 in in IN cord-019051-gtruu1op 539 20 1918/1919 1918/1919 CD cord-019051-gtruu1op 539 21 , , , cord-019051-gtruu1op 539 22 infecting infect VBG cord-019051-gtruu1op 539 23 about about IN cord-019051-gtruu1op 539 24 the the DT cord-019051-gtruu1op 539 25 half half NN cord-019051-gtruu1op 539 26 of of IN cord-019051-gtruu1op 539 27 the the DT cord-019051-gtruu1op 539 28 world world NN cord-019051-gtruu1op 539 29 population population NN cord-019051-gtruu1op 539 30 at at IN cord-019051-gtruu1op 539 31 that that DT cord-019051-gtruu1op 539 32 time time NN cord-019051-gtruu1op 539 33 and and CC cord-019051-gtruu1op 539 34 killing kill VBG cord-019051-gtruu1op 539 35 approximately approximately RB cord-019051-gtruu1op 539 36 20 20 CD cord-019051-gtruu1op 539 37 - - SYM cord-019051-gtruu1op 539 38 50 50 CD cord-019051-gtruu1op 539 39 million million CD cord-019051-gtruu1op 539 40 people people NNS cord-019051-gtruu1op 539 41 [ [ -LRB- cord-019051-gtruu1op 539 42 204 204 CD cord-019051-gtruu1op 539 43 ] ] -RRB- cord-019051-gtruu1op 539 44 . . . cord-019051-gtruu1op 540 1 Current current JJ cord-019051-gtruu1op 540 2 pandemic pandemic NN cord-019051-gtruu1op 540 3 concerns concern NNS cord-019051-gtruu1op 540 4 are be VBP cord-019051-gtruu1op 540 5 focused focus VBN cord-019051-gtruu1op 540 6 on on IN cord-019051-gtruu1op 540 7 the the DT cord-019051-gtruu1op 540 8 highly highly RB cord-019051-gtruu1op 540 9 pathogenic pathogenic JJ cord-019051-gtruu1op 540 10 variants variant NNS cord-019051-gtruu1op 540 11 of of IN cord-019051-gtruu1op 540 12 the the DT cord-019051-gtruu1op 540 13 strain strain NN cord-019051-gtruu1op 540 14 A A NNP cord-019051-gtruu1op 540 15 / / SYM cord-019051-gtruu1op 540 16 H5N1 H5N1 NNP cord-019051-gtruu1op 540 17 or or CC cord-019051-gtruu1op 540 18 H1N1 H1N1 NNP cord-019051-gtruu1op 540 19 . . . cord-019051-gtruu1op 541 1 The the DT cord-019051-gtruu1op 541 2 epidemiology epidemiology NN cord-019051-gtruu1op 541 3 of of IN cord-019051-gtruu1op 541 4 influenza influenza NN cord-019051-gtruu1op 541 5 has have VBZ cord-019051-gtruu1op 541 6 been be VBN cord-019051-gtruu1op 541 7 comprehensively comprehensively RB cord-019051-gtruu1op 541 8 reviewed review VBN cord-019051-gtruu1op 541 9 [ [ -LRB- cord-019051-gtruu1op 541 10 220 220 CD cord-019051-gtruu1op 541 11 , , , cord-019051-gtruu1op 541 12 221 221 CD cord-019051-gtruu1op 541 13 ] ] -RRB- cord-019051-gtruu1op 541 14 . . . cord-019051-gtruu1op 542 1 Influenza influenza NN cord-019051-gtruu1op 542 2 is be VBZ cord-019051-gtruu1op 542 3 typically typically RB cord-019051-gtruu1op 542 4 diagnosed diagnose VBN cord-019051-gtruu1op 542 5 clinically clinically RB cord-019051-gtruu1op 542 6 , , , cord-019051-gtruu1op 542 7 but but CC cord-019051-gtruu1op 542 8 laboratory laboratory NN cord-019051-gtruu1op 542 9 diagnosis diagnosis NN cord-019051-gtruu1op 542 10 has have VBZ cord-019051-gtruu1op 542 11 been be VBN cord-019051-gtruu1op 542 12 established establish VBN cord-019051-gtruu1op 542 13 and and CC cord-019051-gtruu1op 542 14 organized organize VBN cord-019051-gtruu1op 542 15 according accord VBG cord-019051-gtruu1op 542 16 to to IN cord-019051-gtruu1op 542 17 standardized standardized JJ cord-019051-gtruu1op 542 18 procedures procedure NNS cord-019051-gtruu1op 542 19 as as IN cord-019051-gtruu1op 542 20 part part NN cord-019051-gtruu1op 542 21 of of IN cord-019051-gtruu1op 542 22 national national JJ cord-019051-gtruu1op 542 23 and and CC cord-019051-gtruu1op 542 24 global global JJ cord-019051-gtruu1op 542 25 pandemic pandemic NN cord-019051-gtruu1op 542 26 plans plan NNS cord-019051-gtruu1op 542 27 . . . cord-019051-gtruu1op 543 1 Several several JJ cord-019051-gtruu1op 543 2 effective effective JJ cord-019051-gtruu1op 543 3 vaccines vaccine NNS cord-019051-gtruu1op 543 4 exist exist VBP cord-019051-gtruu1op 543 5 today today NN cord-019051-gtruu1op 543 6 ( ( -LRB- cord-019051-gtruu1op 543 7 reviewed review VBN cord-019051-gtruu1op 543 8 in in IN cord-019051-gtruu1op 543 9 [ [ -LRB- cord-019051-gtruu1op 543 10 222 222 CD cord-019051-gtruu1op 543 11 ] ] -RRB- cord-019051-gtruu1op 543 12 ) ) -RRB- cord-019051-gtruu1op 543 13 and and CC cord-019051-gtruu1op 543 14 a a DT cord-019051-gtruu1op 543 15 prepandemic prepandemic JJ cord-019051-gtruu1op 543 16 vaccine vaccine NN cord-019051-gtruu1op 543 17 has have VBZ cord-019051-gtruu1op 543 18 been be VBN cord-019051-gtruu1op 543 19 licensed license VBN cord-019051-gtruu1op 543 20 recently recently RB cord-019051-gtruu1op 543 21 . . . cord-019051-gtruu1op 544 1 International International NNP cord-019051-gtruu1op 544 2 Committee Committee NNP cord-019051-gtruu1op 544 3 on on IN cord-019051-gtruu1op 544 4 Taxonomy Taxonomy NNP cord-019051-gtruu1op 544 5 of of IN cord-019051-gtruu1op 544 6 Viruses Viruses NNP cord-019051-gtruu1op 544 7 Rhinoviruses Rhinoviruses NNP cord-019051-gtruu1op 544 8 ( ( -LRB- cord-019051-gtruu1op 544 9 Picornaviridae Picornaviridae NNP cord-019051-gtruu1op 544 10 ) ) -RRB- cord-019051-gtruu1op 544 11 Structure structure NN cord-019051-gtruu1op 544 12 of of IN cord-019051-gtruu1op 544 13 a a DT cord-019051-gtruu1op 544 14 human human JJ cord-019051-gtruu1op 544 15 common common JJ cord-019051-gtruu1op 544 16 cold cold JJ cord-019051-gtruu1op 544 17 virus virus NN cord-019051-gtruu1op 544 18 and and CC cord-019051-gtruu1op 544 19 functional functional JJ cord-019051-gtruu1op 544 20 relationship relationship NN cord-019051-gtruu1op 544 21 to to IN cord-019051-gtruu1op 544 22 other other JJ cord-019051-gtruu1op 544 23 picornaviruses picornaviruses NNP cord-019051-gtruu1op 544 24 Structure Structure NNP cord-019051-gtruu1op 544 25 of of IN cord-019051-gtruu1op 544 26 a a DT cord-019051-gtruu1op 544 27 human human JJ cord-019051-gtruu1op 544 28 rhinovirus rhinovirus NN cord-019051-gtruu1op 544 29 complexed complexe VBN cord-019051-gtruu1op 544 30 with with IN cord-019051-gtruu1op 544 31 its -PRON- PRP$ cord-019051-gtruu1op 544 32 receptor receptor NN cord-019051-gtruu1op 544 33 molecule molecule NN cord-019051-gtruu1op 545 1 Many many JJ cord-019051-gtruu1op 545 2 rhinovirus rhinovirus NN cord-019051-gtruu1op 545 3 serotypes serotype NNS cord-019051-gtruu1op 545 4 share share VBP cord-019051-gtruu1op 545 5 the the DT cord-019051-gtruu1op 545 6 same same JJ cord-019051-gtruu1op 545 7 cellular cellular JJ cord-019051-gtruu1op 545 8 receptor receptor NN cord-019051-gtruu1op 545 9 A a DT cord-019051-gtruu1op 545 10 cell cell NN cord-019051-gtruu1op 545 11 adhesion adhesion NN cord-019051-gtruu1op 545 12 molecule molecule NN cord-019051-gtruu1op 545 13 , , , cord-019051-gtruu1op 545 14 ICAM-1 ICAM-1 NNP cord-019051-gtruu1op 545 15 is be VBZ cord-019051-gtruu1op 545 16 the the DT cord-019051-gtruu1op 545 17 major major JJ cord-019051-gtruu1op 545 18 surface surface NN cord-019051-gtruu1op 545 19 receptor receptor NN cord-019051-gtruu1op 545 20 for for IN cord-019051-gtruu1op 545 21 rhinoviruses rhinovirus NNS cord-019051-gtruu1op 545 22 Cell Cell NNP cord-019051-gtruu1op 545 23 recognition recognition NN cord-019051-gtruu1op 545 24 and and CC cord-019051-gtruu1op 545 25 entry entry NN cord-019051-gtruu1op 545 26 by by IN cord-019051-gtruu1op 545 27 rhino rhino NN cord-019051-gtruu1op 545 28 - - HYPH cord-019051-gtruu1op 545 29 and and CC cord-019051-gtruu1op 545 30 enteroviruses enteroviruses NNP cord-019051-gtruu1op 545 31 Structure Structure NNP cord-019051-gtruu1op 545 32 of of IN cord-019051-gtruu1op 545 33 human human JJ cord-019051-gtruu1op 545 34 rhinovirus rhinovirus NN cord-019051-gtruu1op 545 35 3C 3C NNP cord-019051-gtruu1op 545 36 protease protease NNP cord-019051-gtruu1op 545 37 reveals reveal VBZ cord-019051-gtruu1op 545 38 a a DT cord-019051-gtruu1op 545 39 trypsin trypsin NN cord-019051-gtruu1op 545 40 - - HYPH cord-019051-gtruu1op 545 41 like like JJ cord-019051-gtruu1op 545 42 polypeptide polypeptide NN cord-019051-gtruu1op 545 43 fold fold RB cord-019051-gtruu1op 545 44 , , , cord-019051-gtruu1op 545 45 RNAbinding rnabinding NN cord-019051-gtruu1op 545 46 site site NN cord-019051-gtruu1op 545 47 , , , cord-019051-gtruu1op 545 48 and and CC cord-019051-gtruu1op 545 49 means mean VBZ cord-019051-gtruu1op 545 50 for for IN cord-019051-gtruu1op 545 51 cleaving cleave VBG cord-019051-gtruu1op 545 52 precursor precursor NN cord-019051-gtruu1op 545 53 polyprotein polyprotein NNP cord-019051-gtruu1op 545 54 Transmission Transmission NNP cord-019051-gtruu1op 545 55 of of IN cord-019051-gtruu1op 545 56 rhinovirus rhinovirus NN cord-019051-gtruu1op 545 57 colds cold NNS cord-019051-gtruu1op 545 58 by by IN cord-019051-gtruu1op 545 59 self self NN cord-019051-gtruu1op 545 60 - - HYPH cord-019051-gtruu1op 545 61 inoculation inoculation NN cord-019051-gtruu1op 545 62 An an DT cord-019051-gtruu1op 545 63 investigation investigation NN cord-019051-gtruu1op 545 64 of of IN cord-019051-gtruu1op 545 65 possible possible JJ cord-019051-gtruu1op 545 66 transmission transmission NN cord-019051-gtruu1op 545 67 of of IN cord-019051-gtruu1op 545 68 rhinovirus rhinovirus NN cord-019051-gtruu1op 545 69 colds cold NNS cord-019051-gtruu1op 545 70 through through IN cord-019051-gtruu1op 545 71 indirect indirect JJ cord-019051-gtruu1op 545 72 contact contact NN cord-019051-gtruu1op 545 73 Hand hand NN cord-019051-gtruu1op 545 74 - - HYPH cord-019051-gtruu1op 545 75 to to IN cord-019051-gtruu1op 545 76 - - HYPH cord-019051-gtruu1op 545 77 hand hand NN cord-019051-gtruu1op 545 78 transmission transmission NN cord-019051-gtruu1op 545 79 of of IN cord-019051-gtruu1op 545 80 rhinovirus rhinovirus NN cord-019051-gtruu1op 545 81 colds cold NNS cord-019051-gtruu1op 545 82 Effect effect NN cord-019051-gtruu1op 545 83 of of IN cord-019051-gtruu1op 545 84 route route NN cord-019051-gtruu1op 545 85 of of IN cord-019051-gtruu1op 545 86 inoculation inoculation NN cord-019051-gtruu1op 545 87 on on IN cord-019051-gtruu1op 545 88 experimental experimental JJ cord-019051-gtruu1op 545 89 respiratory respiratory JJ cord-019051-gtruu1op 545 90 viral viral JJ cord-019051-gtruu1op 545 91 disease disease NN cord-019051-gtruu1op 545 92 in in IN cord-019051-gtruu1op 545 93 volunteers volunteer NNS cord-019051-gtruu1op 545 94 and and CC cord-019051-gtruu1op 545 95 evidence evidence NN cord-019051-gtruu1op 545 96 for for IN cord-019051-gtruu1op 545 97 airborne airborne JJ cord-019051-gtruu1op 545 98 transmission transmission NN cord-019051-gtruu1op 545 99 Quantitative quantitative JJ cord-019051-gtruu1op 545 100 rhinovirus rhinovirus NN cord-019051-gtruu1op 545 101 shedding shed VBG cord-019051-gtruu1op 545 102 patterns pattern NNS cord-019051-gtruu1op 545 103 in in IN cord-019051-gtruu1op 545 104 volunteers volunteer NNS cord-019051-gtruu1op 545 105 Localization Localization NNP cord-019051-gtruu1op 545 106 of of IN cord-019051-gtruu1op 545 107 rhinovirus rhinovirus NN cord-019051-gtruu1op 545 108 replication replication NN cord-019051-gtruu1op 546 1 In in IN cord-019051-gtruu1op 546 2 vitro vitro FW cord-019051-gtruu1op 546 3 with with IN cord-019051-gtruu1op 546 4 in in IN cord-019051-gtruu1op 546 5 situ situ NN cord-019051-gtruu1op 546 6 hybridization hybridization NN cord-019051-gtruu1op 546 7 Respiratory respiratory JJ cord-019051-gtruu1op 546 8 virus virus NN cord-019051-gtruu1op 546 9 infection infection NN cord-019051-gtruu1op 546 10 of of IN cord-019051-gtruu1op 546 11 monolayer monolayer NN cord-019051-gtruu1op 546 12 cultures culture NNS cord-019051-gtruu1op 546 13 of of IN cord-019051-gtruu1op 546 14 human human JJ cord-019051-gtruu1op 546 15 nasal nasal NN cord-019051-gtruu1op 546 16 epithelial epithelial JJ cord-019051-gtruu1op 546 17 cells cell NNS cord-019051-gtruu1op 546 18 Histopathologic Histopathologic NNP cord-019051-gtruu1op 546 19 examination examination NN cord-019051-gtruu1op 546 20 and and CC cord-019051-gtruu1op 546 21 enumeration enumeration NN cord-019051-gtruu1op 546 22 of of IN cord-019051-gtruu1op 546 23 polymorphonuclear polymorphonuclear JJ cord-019051-gtruu1op 546 24 leukocytes leukocyte NNS cord-019051-gtruu1op 546 25 in in IN cord-019051-gtruu1op 546 26 the the DT cord-019051-gtruu1op 546 27 nasal nasal NN cord-019051-gtruu1op 546 28 mucosa mucosa JJ cord-019051-gtruu1op 546 29 during during IN cord-019051-gtruu1op 546 30 experimental experimental JJ cord-019051-gtruu1op 546 31 rhinovirus rhinovirus NN cord-019051-gtruu1op 546 32 colds cold NNS cord-019051-gtruu1op 546 33 Localization Localization NNP cord-019051-gtruu1op 546 34 of of IN cord-019051-gtruu1op 546 35 human human JJ cord-019051-gtruu1op 546 36 rhinovirus rhinovirus NN cord-019051-gtruu1op 546 37 replication replication NN cord-019051-gtruu1op 546 38 in in IN cord-019051-gtruu1op 546 39 the the DT cord-019051-gtruu1op 546 40 upper upper JJ cord-019051-gtruu1op 546 41 respiratory respiratory JJ cord-019051-gtruu1op 546 42 tract tract NN cord-019051-gtruu1op 546 43 by by IN cord-019051-gtruu1op 546 44 in in IN cord-019051-gtruu1op 546 45 situ situ NN cord-019051-gtruu1op 546 46 hybridization hybridization NN cord-019051-gtruu1op 546 47 Shedding shedding NN cord-019051-gtruu1op 546 48 of of IN cord-019051-gtruu1op 546 49 infected infected JJ cord-019051-gtruu1op 546 50 ciliated ciliated JJ cord-019051-gtruu1op 546 51 epithelial epithelial JJ cord-019051-gtruu1op 546 52 cells cell NNS cord-019051-gtruu1op 546 53 in in IN cord-019051-gtruu1op 546 54 rhinovirus rhinovirus NN cord-019051-gtruu1op 546 55 colds cold NNS cord-019051-gtruu1op 546 56 Association Association NNP cord-019051-gtruu1op 546 57 between between IN cord-019051-gtruu1op 546 58 nasal nasal NN cord-019051-gtruu1op 546 59 secretion secretion NN cord-019051-gtruu1op 546 60 interleukin-8 interleukin-8 NNP cord-019051-gtruu1op 546 61 concentration concentration NN cord-019051-gtruu1op 546 62 and and CC cord-019051-gtruu1op 546 63 symptom symptom NN cord-019051-gtruu1op 546 64 severity severity NN cord-019051-gtruu1op 546 65 in in IN cord-019051-gtruu1op 546 66 experimental experimental JJ cord-019051-gtruu1op 546 67 rhinovirus rhinovirus NN cord-019051-gtruu1op 546 68 colds cold NNS cord-019051-gtruu1op 547 1 Increased increase VBN cord-019051-gtruu1op 547 2 levels level NNS cord-019051-gtruu1op 547 3 of of IN cord-019051-gtruu1op 547 4 interleukin-1 interleukin-1 NN cord-019051-gtruu1op 547 5 are be VBP cord-019051-gtruu1op 547 6 detected detect VBN cord-019051-gtruu1op 547 7 in in IN cord-019051-gtruu1op 547 8 nasal nasal JJ cord-019051-gtruu1op 547 9 secretions secretion NNS cord-019051-gtruu1op 547 10 of of IN cord-019051-gtruu1op 547 11 volunteers volunteer NNS cord-019051-gtruu1op 547 12 during during IN cord-019051-gtruu1op 547 13 experimental experimental JJ cord-019051-gtruu1op 547 14 rhinovirus rhinovirus NN cord-019051-gtruu1op 547 15 colds cold NNS cord-019051-gtruu1op 547 16 Rhinovirus Rhinovirus NNP cord-019051-gtruu1op 547 17 stimulation stimulation NN cord-019051-gtruu1op 547 18 of of IN cord-019051-gtruu1op 547 19 interleukin-6 interleukin-6 NNP cord-019051-gtruu1op 547 20 in in IN cord-019051-gtruu1op 547 21 vivo vivo NN cord-019051-gtruu1op 547 22 and and CC cord-019051-gtruu1op 547 23 In in IN cord-019051-gtruu1op 547 24 vitro vitro FW cord-019051-gtruu1op 547 25 : : : cord-019051-gtruu1op 547 26 Evidence evidence NN cord-019051-gtruu1op 547 27 for for IN cord-019051-gtruu1op 547 28 nuclear nuclear JJ cord-019051-gtruu1op 547 29 factor factor NN cord-019051-gtruu1op 548 1 kB kb LS cord-019051-gtruu1op 548 2 - - HYPH cord-019051-gtruu1op 548 3 dependent dependent JJ cord-019051-gtruu1op 548 4 transcriptional transcriptional JJ cord-019051-gtruu1op 548 5 activation activation NN cord-019051-gtruu1op 548 6 Rhinoviruses Rhinoviruses NNP cord-019051-gtruu1op 548 7 infect infect VBP cord-019051-gtruu1op 548 8 the the DT cord-019051-gtruu1op 548 9 lower low JJR cord-019051-gtruu1op 548 10 airways airway NNS cord-019051-gtruu1op 548 11 Recurrent recurrent JJ cord-019051-gtruu1op 548 12 wheezy wheezy JJ cord-019051-gtruu1op 548 13 bronchitis bronchitis NN cord-019051-gtruu1op 548 14 and and CC cord-019051-gtruu1op 548 15 viral viral JJ cord-019051-gtruu1op 548 16 respiratory respiratory JJ cord-019051-gtruu1op 548 17 infections infection NNS cord-019051-gtruu1op 548 18 Rhinovirus rhinovirus NN cord-019051-gtruu1op 548 19 and and CC cord-019051-gtruu1op 548 20 influenza influenza NN cord-019051-gtruu1op 548 21 type type NN cord-019051-gtruu1op 548 22 A a DT cord-019051-gtruu1op 548 23 infections infection NNS cord-019051-gtruu1op 548 24 as as IN cord-019051-gtruu1op 548 25 precipitants precipitant NNS cord-019051-gtruu1op 548 26 of of IN cord-019051-gtruu1op 548 27 asthma asthma NN cord-019051-gtruu1op 548 28 Frequency Frequency NNP cord-019051-gtruu1op 548 29 , , , cord-019051-gtruu1op 548 30 severity severity NN cord-019051-gtruu1op 548 31 , , , cord-019051-gtruu1op 548 32 and and CC cord-019051-gtruu1op 548 33 duration duration NN cord-019051-gtruu1op 548 34 of of IN cord-019051-gtruu1op 548 35 rhinovirus rhinovirus NN cord-019051-gtruu1op 548 36 infections infection NNS cord-019051-gtruu1op 548 37 in in IN cord-019051-gtruu1op 548 38 asthmatic asthmatic JJ cord-019051-gtruu1op 548 39 and and CC cord-019051-gtruu1op 548 40 non non JJ cord-019051-gtruu1op 548 41 - - JJ cord-019051-gtruu1op 548 42 asthmatic asthmatic JJ cord-019051-gtruu1op 548 43 individuals individual NNS cord-019051-gtruu1op 548 44 : : : cord-019051-gtruu1op 548 45 A a DT cord-019051-gtruu1op 548 46 longitudinal longitudinal JJ cord-019051-gtruu1op 548 47 cohort cohort NN cord-019051-gtruu1op 548 48 study study NN cord-019051-gtruu1op 549 1 Neutrophil Neutrophil NNP cord-019051-gtruu1op 549 2 degranulation degranulation NN cord-019051-gtruu1op 549 3 and and CC cord-019051-gtruu1op 549 4 cell cell NN cord-019051-gtruu1op 549 5 lysis lysis NN cord-019051-gtruu1op 549 6 is be VBZ cord-019051-gtruu1op 549 7 associated associate VBN cord-019051-gtruu1op 549 8 with with IN cord-019051-gtruu1op 549 9 clinical clinical JJ cord-019051-gtruu1op 549 10 severity severity NN cord-019051-gtruu1op 549 11 in in IN cord-019051-gtruu1op 549 12 virus virus NN cord-019051-gtruu1op 549 13 - - HYPH cord-019051-gtruu1op 549 14 induced induce VBN cord-019051-gtruu1op 549 15 asthma asthma NN cord-019051-gtruu1op 549 16 Respiratory respiratory JJ cord-019051-gtruu1op 549 17 viruses virus NNS cord-019051-gtruu1op 549 18 and and CC cord-019051-gtruu1op 549 19 exacerbations exacerbation NNS cord-019051-gtruu1op 549 20 of of IN cord-019051-gtruu1op 549 21 asthma asthma NN cord-019051-gtruu1op 549 22 in in IN cord-019051-gtruu1op 549 23 adults adult NNS cord-019051-gtruu1op 550 1 Asthmatic asthmatic JJ cord-019051-gtruu1op 550 2 bronchial bronchial JJ cord-019051-gtruu1op 550 3 epithelial epithelial JJ cord-019051-gtruu1op 550 4 cells cell NNS cord-019051-gtruu1op 550 5 have have VBP cord-019051-gtruu1op 550 6 a a DT cord-019051-gtruu1op 550 7 deficient deficient JJ cord-019051-gtruu1op 550 8 innate innate JJ cord-019051-gtruu1op 550 9 immune immune JJ cord-019051-gtruu1op 550 10 response response NN cord-019051-gtruu1op 550 11 to to IN cord-019051-gtruu1op 550 12 infection infection NN cord-019051-gtruu1op 550 13 with with IN cord-019051-gtruu1op 550 14 rhinovirus rhinovirus NN cord-019051-gtruu1op 550 15 Rhinoviruses Rhinoviruses NNP cord-019051-gtruu1op 550 16 in in IN cord-019051-gtruu1op 550 17 Seattle Seattle NNP cord-019051-gtruu1op 550 18 families family NNS cord-019051-gtruu1op 550 19 , , , cord-019051-gtruu1op 550 20 1975 1975 CD cord-019051-gtruu1op 550 21 - - SYM cord-019051-gtruu1op 550 22 1979 1979 CD cord-019051-gtruu1op 550 23 Viral viral JJ cord-019051-gtruu1op 550 24 infections infection NNS cord-019051-gtruu1op 550 25 and and CC cord-019051-gtruu1op 550 26 treatment treatment NN cord-019051-gtruu1op 550 27 . . . cord-019051-gtruu1op 551 1 Marcel Marcel NNP cord-019051-gtruu1op 551 2 Dekker Dekker NNP cord-019051-gtruu1op 551 3 Recovery Recovery NNP cord-019051-gtruu1op 551 4 of of IN cord-019051-gtruu1op 551 5 new new JJ cord-019051-gtruu1op 551 6 viruses virus NNS cord-019051-gtruu1op 551 7 ( ( -LRB- cord-019051-gtruu1op 551 8 coryzavirus coryzavirus NNP cord-019051-gtruu1op 551 9 ) ) -RRB- cord-019051-gtruu1op 551 10 from from IN cord-019051-gtruu1op 551 11 cases case NNS cord-019051-gtruu1op 551 12 of of IN cord-019051-gtruu1op 551 13 common common JJ cord-019051-gtruu1op 551 14 cold cold NN cord-019051-gtruu1op 551 15 in in IN cord-019051-gtruu1op 551 16 human human JJ cord-019051-gtruu1op 551 17 adults adult NNS cord-019051-gtruu1op 552 1 Viruses virus NNS cord-019051-gtruu1op 552 2 causing cause VBG cord-019051-gtruu1op 552 3 common common JJ cord-019051-gtruu1op 552 4 respiratory respiratory JJ cord-019051-gtruu1op 552 5 infections infection NNS cord-019051-gtruu1op 552 6 in in IN cord-019051-gtruu1op 552 7 man man NN cord-019051-gtruu1op 553 1 Further further JJ cord-019051-gtruu1op 553 2 properties property NNS cord-019051-gtruu1op 553 3 of of IN cord-019051-gtruu1op 553 4 five five CD cord-019051-gtruu1op 553 5 new new JJ cord-019051-gtruu1op 553 6 organized organize VBN cord-019051-gtruu1op 553 7 picornaviruses picornavirus NNS cord-019051-gtruu1op 553 8 ( ( -LRB- cord-019051-gtruu1op 553 9 rhinoviruses rhinovirus NNS cord-019051-gtruu1op 553 10 ) ) -RRB- cord-019051-gtruu1op 553 11 Establishment Establishment NNP cord-019051-gtruu1op 553 12 of of IN cord-019051-gtruu1op 553 13 a a DT cord-019051-gtruu1op 553 14 mouse mouse NN cord-019051-gtruu1op 553 15 model model NN cord-019051-gtruu1op 553 16 for for IN cord-019051-gtruu1op 553 17 human human JJ cord-019051-gtruu1op 553 18 rhinovirus rhinovirus NN cord-019051-gtruu1op 553 19 infection infection NN cord-019051-gtruu1op 553 20 Experimental experimental JJ cord-019051-gtruu1op 553 21 infections infection NNS cord-019051-gtruu1op 553 22 of of IN cord-019051-gtruu1op 553 23 chimpanzees chimpanzee NNS cord-019051-gtruu1op 553 24 with with IN cord-019051-gtruu1op 553 25 human human JJ cord-019051-gtruu1op 553 26 rhinovirus rhinovirus NN cord-019051-gtruu1op 553 27 types type NNS cord-019051-gtruu1op 553 28 14 14 CD cord-019051-gtruu1op 553 29 and and CC cord-019051-gtruu1op 553 30 43 43 CD cord-019051-gtruu1op 553 31 Experimental experimental JJ cord-019051-gtruu1op 553 32 infection infection NN cord-019051-gtruu1op 553 33 of of IN cord-019051-gtruu1op 553 34 gibbons gibbon NNS cord-019051-gtruu1op 553 35 with with IN cord-019051-gtruu1op 553 36 rhinovirus rhinovirus NN cord-019051-gtruu1op 553 37 Mouse Mouse NNP cord-019051-gtruu1op 553 38 models model NNS cord-019051-gtruu1op 553 39 of of IN cord-019051-gtruu1op 553 40 rhinovirus rhinovirus NN cord-019051-gtruu1op 553 41 - - HYPH cord-019051-gtruu1op 553 42 induced induce VBN cord-019051-gtruu1op 553 43 disease disease NN cord-019051-gtruu1op 553 44 and and CC cord-019051-gtruu1op 553 45 exacerbation exacerbation NN cord-019051-gtruu1op 553 46 of of IN cord-019051-gtruu1op 553 47 allergic allergic JJ cord-019051-gtruu1op 553 48 airway airway NN cord-019051-gtruu1op 553 49 inflammation inflammation NN cord-019051-gtruu1op 553 50 Recovery Recovery NNP cord-019051-gtruu1op 553 51 of of IN cord-019051-gtruu1op 553 52 cytopathogenic cytopathogenic JJ cord-019051-gtruu1op 553 53 agent agent NN cord-019051-gtruu1op 553 54 from from IN cord-019051-gtruu1op 553 55 chimpanzees chimpanzee NNS cord-019051-gtruu1op 553 56 with with IN cord-019051-gtruu1op 553 57 coryza coryza NNP cord-019051-gtruu1op 553 58 Respiratory respiratory JJ cord-019051-gtruu1op 553 59 syncytial syncytial JJ cord-019051-gtruu1op 553 60 virus virus NN cord-019051-gtruu1op 553 61 Respiratory respiratory JJ cord-019051-gtruu1op 553 62 syncytial syncytial JJ cord-019051-gtruu1op 553 63 virus virus NN cord-019051-gtruu1op 553 64 . . . cord-019051-gtruu1op 554 1 Brief brief JJ cord-019051-gtruu1op 554 2 review review NN cord-019051-gtruu1op 554 3 International International NNP cord-019051-gtruu1op 554 4 Committee Committee NNP cord-019051-gtruu1op 554 5 on on IN cord-019051-gtruu1op 554 6 Taxonomy Taxonomy NNP cord-019051-gtruu1op 554 7 of of IN cord-019051-gtruu1op 554 8 Viruses Viruses NNPS cord-019051-gtruu1op 555 1 Viral viral JJ cord-019051-gtruu1op 555 2 and and CC cord-019051-gtruu1op 555 3 host host NN cord-019051-gtruu1op 555 4 factors factor NNS cord-019051-gtruu1op 555 5 in in IN cord-019051-gtruu1op 555 6 human human JJ cord-019051-gtruu1op 555 7 respiratory respiratory JJ cord-019051-gtruu1op 555 8 syncytial syncytial JJ cord-019051-gtruu1op 555 9 virus virus NN cord-019051-gtruu1op 555 10 pathogenesis pathogenesis NN cord-019051-gtruu1op 555 11 Morphogenesis morphogenesis NN cord-019051-gtruu1op 555 12 and and CC cord-019051-gtruu1op 555 13 ultrastructure ultrastructure NN cord-019051-gtruu1op 555 14 of of IN cord-019051-gtruu1op 555 15 respiratory respiratory JJ cord-019051-gtruu1op 555 16 syncytial syncytial JJ cord-019051-gtruu1op 555 17 virus virus NN cord-019051-gtruu1op 555 18 siRNA siRNA NNP cord-019051-gtruu1op 555 19 profiling profiling NN cord-019051-gtruu1op 555 20 reveals reveal VBZ cord-019051-gtruu1op 555 21 key key JJ cord-019051-gtruu1op 555 22 role role NN cord-019051-gtruu1op 555 23 of of IN cord-019051-gtruu1op 555 24 clathrin clathrin NN cord-019051-gtruu1op 555 25 - - HYPH cord-019051-gtruu1op 555 26 mediated mediate VBN cord-019051-gtruu1op 555 27 endocytosis endocytosis NN cord-019051-gtruu1op 555 28 and and CC cord-019051-gtruu1op 555 29 early early JJ cord-019051-gtruu1op 555 30 endosome endosome NN cord-019051-gtruu1op 555 31 formation formation NN cord-019051-gtruu1op 555 32 for for IN cord-019051-gtruu1op 555 33 infection infection NN cord-019051-gtruu1op 555 34 by by IN cord-019051-gtruu1op 555 35 respiratory respiratory JJ cord-019051-gtruu1op 555 36 syncytial syncytial JJ cord-019051-gtruu1op 555 37 virus virus NN cord-019051-gtruu1op 555 38 Coupled couple VBN cord-019051-gtruu1op 555 39 translation translation NN cord-019051-gtruu1op 555 40 of of IN cord-019051-gtruu1op 555 41 the the DT cord-019051-gtruu1op 555 42 second second JJ cord-019051-gtruu1op 555 43 ORF ORF NNP cord-019051-gtruu1op 555 44 of of IN cord-019051-gtruu1op 555 45 the the DT cord-019051-gtruu1op 555 46 M2 M2 NNP cord-019051-gtruu1op 555 47 mRNA mRNA NNP cord-019051-gtruu1op 555 48 is be VBZ cord-019051-gtruu1op 555 49 sequence sequence NN cord-019051-gtruu1op 555 50 dependent dependent JJ cord-019051-gtruu1op 555 51 and and CC cord-019051-gtruu1op 555 52 differs differ VBZ cord-019051-gtruu1op 555 53 significantly significantly RB cord-019051-gtruu1op 555 54 in in IN cord-019051-gtruu1op 555 55 the the DT cord-019051-gtruu1op 555 56 subfamily subfamily NN cord-019051-gtruu1op 555 57 Pneumovirinae Pneumovirinae NNP cord-019051-gtruu1op 555 58 Respiratory respiratory JJ cord-019051-gtruu1op 555 59 syncytial syncytial JJ cord-019051-gtruu1op 555 60 virus virus NN cord-019051-gtruu1op 555 61 and and CC cord-019051-gtruu1op 555 62 metapneumovirus metapneumovirus NNP cord-019051-gtruu1op 555 63 Pathogen Pathogen NNP cord-019051-gtruu1op 555 64 recognition recognition NN cord-019051-gtruu1op 555 65 and and CC cord-019051-gtruu1op 555 66 innate innate JJ cord-019051-gtruu1op 555 67 immunity immunity NN cord-019051-gtruu1op 555 68 Retinoic retinoic JJ cord-019051-gtruu1op 555 69 acid acid NN cord-019051-gtruu1op 555 70 - - HYPH cord-019051-gtruu1op 555 71 inducible inducible JJ cord-019051-gtruu1op 555 72 gene gene NN cord-019051-gtruu1op 555 73 I -PRON- PRP cord-019051-gtruu1op 555 74 mediates mediate VBZ cord-019051-gtruu1op 555 75 early early JJ cord-019051-gtruu1op 555 76 Antiviral Antiviral NNP cord-019051-gtruu1op 555 77 Response Response NNP cord-019051-gtruu1op 555 78 and and CC cord-019051-gtruu1op 555 79 Toll Toll NNP cord-019051-gtruu1op 555 80 - - HYPH cord-019051-gtruu1op 555 81 like like JJ cord-019051-gtruu1op 555 82 receptor receptor NN cord-019051-gtruu1op 555 83 3 3 CD cord-019051-gtruu1op 555 84 expression expression NN cord-019051-gtruu1op 555 85 in in IN cord-019051-gtruu1op 555 86 respiratory respiratory JJ cord-019051-gtruu1op 555 87 syncytial syncytial JJ cord-019051-gtruu1op 555 88 virus virus NN cord-019051-gtruu1op 555 89 - - HYPH cord-019051-gtruu1op 555 90 infected infect VBN cord-019051-gtruu1op 555 91 airway airway NN cord-019051-gtruu1op 555 92 epithelial epithelial JJ cord-019051-gtruu1op 555 93 cells cell NNS cord-019051-gtruu1op 555 94 Identification identification NN cord-019051-gtruu1op 555 95 of of IN cord-019051-gtruu1op 555 96 the the DT cord-019051-gtruu1op 555 97 respiratory respiratory JJ cord-019051-gtruu1op 555 98 syncytial syncytial JJ cord-019051-gtruu1op 555 99 virus virus NN cord-019051-gtruu1op 555 100 proteins protein NNS cord-019051-gtruu1op 555 101 required require VBN cord-019051-gtruu1op 555 102 for for IN cord-019051-gtruu1op 555 103 formation formation NN cord-019051-gtruu1op 555 104 and and CC cord-019051-gtruu1op 555 105 passage passage NN cord-019051-gtruu1op 555 106 of of IN cord-019051-gtruu1op 555 107 helper helper NN cord-019051-gtruu1op 555 108 - - HYPH cord-019051-gtruu1op 555 109 dependent dependent JJ cord-019051-gtruu1op 555 110 infectious infectious JJ cord-019051-gtruu1op 555 111 particles particle NNS cord-019051-gtruu1op 556 1 The the DT cord-019051-gtruu1op 556 2 central central JJ cord-019051-gtruu1op 556 3 conserved conserved JJ cord-019051-gtruu1op 556 4 cystine cystine NN cord-019051-gtruu1op 556 5 noose noose NN cord-019051-gtruu1op 556 6 of of IN cord-019051-gtruu1op 556 7 the the DT cord-019051-gtruu1op 556 8 attachment attachment NN cord-019051-gtruu1op 556 9 G G NNP cord-019051-gtruu1op 556 10 protein protein NN cord-019051-gtruu1op 556 11 of of IN cord-019051-gtruu1op 556 12 human human JJ cord-019051-gtruu1op 556 13 respiratory respiratory JJ cord-019051-gtruu1op 556 14 syncytial syncytial JJ cord-019051-gtruu1op 556 15 virus virus NN cord-019051-gtruu1op 556 16 is be VBZ cord-019051-gtruu1op 556 17 not not RB cord-019051-gtruu1op 556 18 required require VBN cord-019051-gtruu1op 556 19 for for IN cord-019051-gtruu1op 556 20 efficient efficient JJ cord-019051-gtruu1op 556 21 viral viral JJ cord-019051-gtruu1op 556 22 infection infection NN cord-019051-gtruu1op 557 1 In in IN cord-019051-gtruu1op 557 2 vitro vitro FW cord-019051-gtruu1op 557 3 or or CC cord-019051-gtruu1op 557 4 in in IN cord-019051-gtruu1op 557 5 vivo vivo NNP cord-019051-gtruu1op 557 6 Cleavage cleavage NN cord-019051-gtruu1op 557 7 of of IN cord-019051-gtruu1op 557 8 the the DT cord-019051-gtruu1op 557 9 human human JJ cord-019051-gtruu1op 557 10 respiratory respiratory JJ cord-019051-gtruu1op 557 11 syncytial syncytial JJ cord-019051-gtruu1op 557 12 virus virus NN cord-019051-gtruu1op 557 13 fusion fusion NN cord-019051-gtruu1op 557 14 protein protein NN cord-019051-gtruu1op 557 15 at at IN cord-019051-gtruu1op 557 16 two two CD cord-019051-gtruu1op 557 17 distinct distinct JJ cord-019051-gtruu1op 557 18 sites site NNS cord-019051-gtruu1op 557 19 is be VBZ cord-019051-gtruu1op 557 20 required require VBN cord-019051-gtruu1op 557 21 for for IN cord-019051-gtruu1op 557 22 activation activation NN cord-019051-gtruu1op 557 23 of of IN cord-019051-gtruu1op 557 24 membrane membrane NN cord-019051-gtruu1op 557 25 fusion fusion NN cord-019051-gtruu1op 557 26 Respiratory respiratory JJ cord-019051-gtruu1op 557 27 syncytial syncytial JJ cord-019051-gtruu1op 557 28 virus virus NN cord-019051-gtruu1op 557 29 and and CC cord-019051-gtruu1op 557 30 metapneumovirus metapneumovirus NNP cord-019051-gtruu1op 558 1 The the DT cord-019051-gtruu1op 558 2 pathogenesis pathogenesis NN cord-019051-gtruu1op 558 3 of of IN cord-019051-gtruu1op 558 4 respiratory respiratory JJ cord-019051-gtruu1op 558 5 syncytial syncytial JJ cord-019051-gtruu1op 558 6 virus virus NN cord-019051-gtruu1op 558 7 disease disease NN cord-019051-gtruu1op 558 8 in in IN cord-019051-gtruu1op 558 9 childhood childhood NN cord-019051-gtruu1op 558 10 Respiratory respiratory JJ cord-019051-gtruu1op 558 11 syncytial syncytial JJ cord-019051-gtruu1op 558 12 virus virus NN cord-019051-gtruu1op 558 13 Respiratory respiratory JJ cord-019051-gtruu1op 558 14 syncytial syncytial JJ cord-019051-gtruu1op 558 15 virus virus NN cord-019051-gtruu1op 558 16 in in IN cord-019051-gtruu1op 558 17 early early JJ cord-019051-gtruu1op 558 18 life life NN cord-019051-gtruu1op 558 19 and and CC cord-019051-gtruu1op 558 20 risk risk NN cord-019051-gtruu1op 558 21 of of IN cord-019051-gtruu1op 558 22 wheeze wheeze NN cord-019051-gtruu1op 558 23 and and CC cord-019051-gtruu1op 558 24 allergy allergy NN cord-019051-gtruu1op 558 25 by by IN cord-019051-gtruu1op 558 26 age age NN cord-019051-gtruu1op 558 27 of of IN cord-019051-gtruu1op 558 28 13 13 CD cord-019051-gtruu1op 558 29 Respiratory respiratory JJ cord-019051-gtruu1op 558 30 syncytial syncytial JJ cord-019051-gtruu1op 558 31 virus virus NN cord-019051-gtruu1op 558 32 infections infection NNS cord-019051-gtruu1op 558 33 in in IN cord-019051-gtruu1op 558 34 immunocompromised immunocompromised JJ cord-019051-gtruu1op 558 35 adults adult NNS cord-019051-gtruu1op 559 1 Speculation speculation NN cord-019051-gtruu1op 559 2 on on IN cord-019051-gtruu1op 559 3 pathogenesis pathogenesis NN cord-019051-gtruu1op 559 4 in in IN cord-019051-gtruu1op 559 5 death death NN cord-019051-gtruu1op 559 6 from from IN cord-019051-gtruu1op 559 7 respiratory respiratory JJ cord-019051-gtruu1op 559 8 syncytial syncytial JJ cord-019051-gtruu1op 559 9 virus virus NN cord-019051-gtruu1op 559 10 infection infection NN cord-019051-gtruu1op 559 11 Prevalence prevalence NN cord-019051-gtruu1op 559 12 of of IN cord-019051-gtruu1op 559 13 various various JJ cord-019051-gtruu1op 559 14 respiratory respiratory JJ cord-019051-gtruu1op 559 15 viruses virus NNS cord-019051-gtruu1op 559 16 in in IN cord-019051-gtruu1op 559 17 the the DT cord-019051-gtruu1op 559 18 middle middle JJ cord-019051-gtruu1op 559 19 ear ear NN cord-019051-gtruu1op 559 20 during during IN cord-019051-gtruu1op 559 21 acute acute JJ cord-019051-gtruu1op 559 22 otitis otitis NN cord-019051-gtruu1op 559 23 media medium NNS cord-019051-gtruu1op 559 24 Pathological pathological JJ cord-019051-gtruu1op 559 25 changes change NNS cord-019051-gtruu1op 559 26 in in IN cord-019051-gtruu1op 559 27 virus virus NN cord-019051-gtruu1op 559 28 infections infection NNS cord-019051-gtruu1op 559 29 of of IN cord-019051-gtruu1op 559 30 the the DT cord-019051-gtruu1op 559 31 lower low JJR cord-019051-gtruu1op 559 32 respiratory respiratory JJ cord-019051-gtruu1op 559 33 tract tract NN cord-019051-gtruu1op 559 34 in in IN cord-019051-gtruu1op 559 35 children child NNS cord-019051-gtruu1op 559 36 Respiratory respiratory JJ cord-019051-gtruu1op 559 37 syncytial syncytial JJ cord-019051-gtruu1op 559 38 virus virus NN cord-019051-gtruu1op 559 39 Respiratory respiratory JJ cord-019051-gtruu1op 559 40 syncytial syncytial JJ cord-019051-gtruu1op 559 41 virus virus NN cord-019051-gtruu1op 559 42 : : : cord-019051-gtruu1op 559 43 Update update VB cord-019051-gtruu1op 559 44 on on IN cord-019051-gtruu1op 559 45 infection infection NN cord-019051-gtruu1op 559 46 , , , cord-019051-gtruu1op 559 47 treatment treatment NN cord-019051-gtruu1op 559 48 and and CC cord-019051-gtruu1op 559 49 prevention prevention NN cord-019051-gtruu1op 560 1 The the DT cord-019051-gtruu1op 560 2 epidemiology epidemiology NN cord-019051-gtruu1op 560 3 of of IN cord-019051-gtruu1op 560 4 acute acute JJ cord-019051-gtruu1op 560 5 respiratory respiratory JJ cord-019051-gtruu1op 560 6 tract tract NN cord-019051-gtruu1op 560 7 infection infection NN cord-019051-gtruu1op 560 8 in in IN cord-019051-gtruu1op 560 9 young young JJ cord-019051-gtruu1op 560 10 children child NNS cord-019051-gtruu1op 560 11 Risk risk NN cord-019051-gtruu1op 560 12 of of IN cord-019051-gtruu1op 560 13 respiratory respiratory JJ cord-019051-gtruu1op 560 14 syncytial syncytial JJ cord-019051-gtruu1op 560 15 virus virus NN cord-019051-gtruu1op 560 16 infection infection NN cord-019051-gtruu1op 560 17 for for IN cord-019051-gtruu1op 560 18 infants infant NNS cord-019051-gtruu1op 560 19 from from IN cord-019051-gtruu1op 560 20 low low JJ cord-019051-gtruu1op 560 21 - - HYPH cord-019051-gtruu1op 560 22 income income NN cord-019051-gtruu1op 560 23 families family NNS cord-019051-gtruu1op 560 24 in in IN cord-019051-gtruu1op 560 25 relationship relationship NN cord-019051-gtruu1op 560 26 to to IN cord-019051-gtruu1op 560 27 age age NN cord-019051-gtruu1op 560 28 , , , cord-019051-gtruu1op 560 29 sex sex NN cord-019051-gtruu1op 560 30 , , , cord-019051-gtruu1op 560 31 ethnic ethnic JJ cord-019051-gtruu1op 560 32 group group NN cord-019051-gtruu1op 560 33 and and CC cord-019051-gtruu1op 560 34 maternal maternal JJ cord-019051-gtruu1op 560 35 antibody antibody NN cord-019051-gtruu1op 560 36 level level NN cord-019051-gtruu1op 560 37 Respiratory respiratory JJ cord-019051-gtruu1op 560 38 syncytial syncytial JJ cord-019051-gtruu1op 560 39 virus virus NN cord-019051-gtruu1op 560 40 Differential differential JJ cord-019051-gtruu1op 560 41 production production NN cord-019051-gtruu1op 560 42 of of IN cord-019051-gtruu1op 560 43 inflammatory inflammatory JJ cord-019051-gtruu1op 560 44 cytokines cytokine NNS cord-019051-gtruu1op 560 45 in in IN cord-019051-gtruu1op 560 46 primary primary JJ cord-019051-gtruu1op 560 47 infection infection NN cord-019051-gtruu1op 560 48 with with IN cord-019051-gtruu1op 560 49 human human JJ cord-019051-gtruu1op 560 50 metapneumovirus metapneumovirus NN cord-019051-gtruu1op 560 51 and and CC cord-019051-gtruu1op 560 52 with with IN cord-019051-gtruu1op 560 53 other other JJ cord-019051-gtruu1op 560 54 common common JJ cord-019051-gtruu1op 560 55 respiratory respiratory JJ cord-019051-gtruu1op 560 56 viruses virus NNS cord-019051-gtruu1op 560 57 of of IN cord-019051-gtruu1op 560 58 infancy infancy JJ cord-019051-gtruu1op 560 59 Effectiveness Effectiveness NNP cord-019051-gtruu1op 560 60 of of IN cord-019051-gtruu1op 560 61 drug drug NN cord-019051-gtruu1op 560 62 therapies therapy NNS cord-019051-gtruu1op 560 63 to to TO cord-019051-gtruu1op 560 64 treat treat VB cord-019051-gtruu1op 560 65 or or CC cord-019051-gtruu1op 560 66 prevent prevent VB cord-019051-gtruu1op 560 67 respiratory respiratory JJ cord-019051-gtruu1op 560 68 syncytial syncytial JJ cord-019051-gtruu1op 560 69 virus virus NN cord-019051-gtruu1op 560 70 infection infection NN cord-019051-gtruu1op 560 71 - - HYPH cord-019051-gtruu1op 560 72 related relate VBN cord-019051-gtruu1op 560 73 morbidity morbidity NN cord-019051-gtruu1op 560 74 Genetic genetic JJ cord-019051-gtruu1op 560 75 susceptibility susceptibility NN cord-019051-gtruu1op 560 76 to to IN cord-019051-gtruu1op 560 77 RSV RSV NNP cord-019051-gtruu1op 560 78 disease disease NN cord-019051-gtruu1op 560 79 Bronchoalveolar Bronchoalveolar NNP cord-019051-gtruu1op 560 80 lavage lavage NN cord-019051-gtruu1op 560 81 cytokine cytokine NN cord-019051-gtruu1op 560 82 profiles profile NNS cord-019051-gtruu1op 560 83 in in IN cord-019051-gtruu1op 560 84 acute acute JJ cord-019051-gtruu1op 560 85 asthma asthma NN cord-019051-gtruu1op 560 86 and and CC cord-019051-gtruu1op 560 87 acute acute JJ cord-019051-gtruu1op 560 88 bronchiolitis bronchiolitis NN cord-019051-gtruu1op 560 89 Human human JJ cord-019051-gtruu1op 560 90 infant infant NN cord-019051-gtruu1op 560 91 respiratory respiratory JJ cord-019051-gtruu1op 560 92 syncytial syncytial JJ cord-019051-gtruu1op 560 93 virus virus NN cord-019051-gtruu1op 560 94 ( ( -LRB- cord-019051-gtruu1op 560 95 RSV)-specific rsv)-specific NN cord-019051-gtruu1op 560 96 type type NN cord-019051-gtruu1op 560 97 1 1 CD cord-019051-gtruu1op 560 98 and and CC cord-019051-gtruu1op 560 99 2 2 CD cord-019051-gtruu1op 560 100 cytokine cytokine NN cord-019051-gtruu1op 560 101 responses response NNS cord-019051-gtruu1op 560 102 ex ex FW cord-019051-gtruu1op 560 103 vivo vivo NN cord-019051-gtruu1op 560 104 during during IN cord-019051-gtruu1op 560 105 primary primary JJ cord-019051-gtruu1op 560 106 RSV RSV NNP cord-019051-gtruu1op 560 107 infection infection NN cord-019051-gtruu1op 560 108 Type type NN cord-019051-gtruu1op 560 109 1 1 CD cord-019051-gtruu1op 560 110 and and CC cord-019051-gtruu1op 560 111 type type NN cord-019051-gtruu1op 560 112 2 2 CD cord-019051-gtruu1op 560 113 cytokine cytokine NN cord-019051-gtruu1op 560 114 imbalance imbalance NN cord-019051-gtruu1op 560 115 in in IN cord-019051-gtruu1op 560 116 acute acute JJ cord-019051-gtruu1op 560 117 respiratory respiratory JJ cord-019051-gtruu1op 560 118 syncytial syncytial JJ cord-019051-gtruu1op 560 119 virus virus NN cord-019051-gtruu1op 560 120 bronchiolitis bronchiolitis NN cord-019051-gtruu1op 560 121 Priming prime VBG cord-019051-gtruu1op 560 122 immunization immunization NN cord-019051-gtruu1op 560 123 determines determine VBZ cord-019051-gtruu1op 560 124 T T NNP cord-019051-gtruu1op 560 125 helper helper NN cord-019051-gtruu1op 560 126 cytokine cytokine NN cord-019051-gtruu1op 560 127 mRNA mrna NN cord-019051-gtruu1op 560 128 expression expression NN cord-019051-gtruu1op 560 129 patterns pattern NNS cord-019051-gtruu1op 560 130 in in IN cord-019051-gtruu1op 560 131 lungs lung NNS cord-019051-gtruu1op 560 132 of of IN cord-019051-gtruu1op 560 133 mice mouse NNS cord-019051-gtruu1op 560 134 challenged challenge VBN cord-019051-gtruu1op 560 135 with with IN cord-019051-gtruu1op 560 136 respiratory respiratory JJ cord-019051-gtruu1op 560 137 syncytial syncytial JJ cord-019051-gtruu1op 560 138 virus virus NN cord-019051-gtruu1op 560 139 Respiratory respiratory JJ cord-019051-gtruu1op 560 140 syncytial syncytial JJ cord-019051-gtruu1op 560 141 virus virus NN cord-019051-gtruu1op 560 142 deficient deficient JJ cord-019051-gtruu1op 560 143 in in IN cord-019051-gtruu1op 560 144 soluble soluble JJ cord-019051-gtruu1op 560 145 G g NN cord-019051-gtruu1op 560 146 protein protein NN cord-019051-gtruu1op 560 147 induced induce VBD cord-019051-gtruu1op 560 148 an an DT cord-019051-gtruu1op 560 149 increased increase VBN cord-019051-gtruu1op 560 150 proinflammatory proinflammatory JJ cord-019051-gtruu1op 560 151 response response NN cord-019051-gtruu1op 560 152 in in IN cord-019051-gtruu1op 560 153 human human JJ cord-019051-gtruu1op 560 154 lung lung NN cord-019051-gtruu1op 560 155 epithelial epithelial NN cord-019051-gtruu1op 560 156 cells cell NNS cord-019051-gtruu1op 561 1 The the DT cord-019051-gtruu1op 561 2 cysteinerich cysteinerich NN cord-019051-gtruu1op 561 3 region region NN cord-019051-gtruu1op 561 4 of of IN cord-019051-gtruu1op 561 5 respiratory respiratory JJ cord-019051-gtruu1op 561 6 syncytial syncytial JJ cord-019051-gtruu1op 561 7 virus virus NN cord-019051-gtruu1op 561 8 attachment attachment NN cord-019051-gtruu1op 561 9 protein protein NN cord-019051-gtruu1op 561 10 inhibits inhibit VBZ cord-019051-gtruu1op 561 11 innate innate JJ cord-019051-gtruu1op 561 12 immunity immunity NN cord-019051-gtruu1op 561 13 elicited elicit VBN cord-019051-gtruu1op 561 14 by by IN cord-019051-gtruu1op 561 15 the the DT cord-019051-gtruu1op 561 16 virus virus NN cord-019051-gtruu1op 561 17 and and CC cord-019051-gtruu1op 561 18 endotoxin endotoxin NN cord-019051-gtruu1op 561 19 Pattern Pattern NNP cord-019051-gtruu1op 561 20 recognition recognition NN cord-019051-gtruu1op 561 21 receptors receptor NNS cord-019051-gtruu1op 561 22 TLR4 TLR4 NNP cord-019051-gtruu1op 561 23 and and CC cord-019051-gtruu1op 561 24 CD14 CD14 NNP cord-019051-gtruu1op 561 25 mediate mediate VBP cord-019051-gtruu1op 561 26 response response NN cord-019051-gtruu1op 561 27 to to IN cord-019051-gtruu1op 561 28 respiratory respiratory JJ cord-019051-gtruu1op 561 29 syncytial syncytial JJ cord-019051-gtruu1op 561 30 virus virus NN cord-019051-gtruu1op 561 31 Severe severe JJ cord-019051-gtruu1op 561 32 respiratory respiratory JJ cord-019051-gtruu1op 561 33 syncytial syncytial JJ cord-019051-gtruu1op 561 34 virus virus NN cord-019051-gtruu1op 561 35 disease disease NN cord-019051-gtruu1op 561 36 in in IN cord-019051-gtruu1op 561 37 Alaska Alaska NNP cord-019051-gtruu1op 561 38 native native JJ cord-019051-gtruu1op 561 39 children child NNS cord-019051-gtruu1op 561 40 Palivizumab Palivizumab NNP cord-019051-gtruu1op 561 41 in in IN cord-019051-gtruu1op 561 42 the the DT cord-019051-gtruu1op 561 43 prophylaxis prophylaxis NN cord-019051-gtruu1op 561 44 of of IN cord-019051-gtruu1op 561 45 respiratory respiratory JJ cord-019051-gtruu1op 561 46 syncytial syncytial JJ cord-019051-gtruu1op 561 47 virus virus NN cord-019051-gtruu1op 561 48 infection infection NN cord-019051-gtruu1op 561 49 Respiratory respiratory JJ cord-019051-gtruu1op 561 50 syncytial syncytial JJ cord-019051-gtruu1op 561 51 virus virus NN cord-019051-gtruu1op 561 52 disease disease NN cord-019051-gtruu1op 561 53 mechanisms mechanism NNS cord-019051-gtruu1op 561 54 implicated implicate VBN cord-019051-gtruu1op 561 55 by by IN cord-019051-gtruu1op 561 56 human human JJ cord-019051-gtruu1op 561 57 , , , cord-019051-gtruu1op 561 58 animal animal NN cord-019051-gtruu1op 561 59 model model NN cord-019051-gtruu1op 561 60 , , , cord-019051-gtruu1op 561 61 and and CC cord-019051-gtruu1op 561 62 In in IN cord-019051-gtruu1op 561 63 vitro vitro FW cord-019051-gtruu1op 561 64 data datum NNS cord-019051-gtruu1op 561 65 facilitate facilitate VBP cord-019051-gtruu1op 561 66 vaccine vaccine NN cord-019051-gtruu1op 561 67 strategies strategy NNS cord-019051-gtruu1op 561 68 and and CC cord-019051-gtruu1op 561 69 new new JJ cord-019051-gtruu1op 561 70 therapeutics therapeutic NNS cord-019051-gtruu1op 561 71 Experimental Experimental NNP cord-019051-gtruu1op 561 72 respiratory respiratory JJ cord-019051-gtruu1op 561 73 syncytial syncytial JJ cord-019051-gtruu1op 561 74 virus virus NN cord-019051-gtruu1op 561 75 infection infection NN cord-019051-gtruu1op 561 76 of of IN cord-019051-gtruu1op 561 77 four four CD cord-019051-gtruu1op 561 78 species specie NNS cord-019051-gtruu1op 561 79 of of IN cord-019051-gtruu1op 561 80 primates primate NNS cord-019051-gtruu1op 561 81 Respiratory respiratory JJ cord-019051-gtruu1op 561 82 syncytial syncytial JJ cord-019051-gtruu1op 561 83 virus virus NN cord-019051-gtruu1op 561 84 infects infect VBZ cord-019051-gtruu1op 561 85 the the DT cord-019051-gtruu1op 561 86 bonnet bonnet NN cord-019051-gtruu1op 561 87 monkey monkey NN cord-019051-gtruu1op 561 88 , , , cord-019051-gtruu1op 561 89 Macaca Macaca NNP cord-019051-gtruu1op 561 90 radiata radiata NN cord-019051-gtruu1op 562 1 The the DT cord-019051-gtruu1op 562 2 pathogenesis pathogenesis NN cord-019051-gtruu1op 562 3 of of IN cord-019051-gtruu1op 562 4 respiratory respiratory JJ cord-019051-gtruu1op 562 5 syncytial syncytial JJ cord-019051-gtruu1op 562 6 virus virus NN cord-019051-gtruu1op 562 7 infection infection NN cord-019051-gtruu1op 562 8 in in IN cord-019051-gtruu1op 562 9 cotton cotton NN cord-019051-gtruu1op 562 10 rats rat NNS cord-019051-gtruu1op 562 11 Enhancement enhancement NN cord-019051-gtruu1op 562 12 of of IN cord-019051-gtruu1op 562 13 respiratory respiratory JJ cord-019051-gtruu1op 562 14 syncytial syncytial JJ cord-019051-gtruu1op 562 15 virus virus NN cord-019051-gtruu1op 562 16 pulmonary pulmonary JJ cord-019051-gtruu1op 562 17 pathology pathology NN cord-019051-gtruu1op 562 18 in in IN cord-019051-gtruu1op 562 19 cotton cotton NN cord-019051-gtruu1op 562 20 rats rat NNS cord-019051-gtruu1op 562 21 by by IN cord-019051-gtruu1op 562 22 prior prior JJ cord-019051-gtruu1op 562 23 intramuscular intramuscular JJ cord-019051-gtruu1op 562 24 inoculation inoculation NN cord-019051-gtruu1op 562 25 of of IN cord-019051-gtruu1op 562 26 formalin formalin NN cord-019051-gtruu1op 562 27 - - HYPH cord-019051-gtruu1op 562 28 inactivated inactivate VBN cord-019051-gtruu1op 562 29 virus virus NN cord-019051-gtruu1op 562 30 Mechanism mechanism NN cord-019051-gtruu1op 562 31 of of IN cord-019051-gtruu1op 562 32 antibody antibody NN cord-019051-gtruu1op 562 33 - - HYPH cord-019051-gtruu1op 562 34 mediated mediate VBN cord-019051-gtruu1op 562 35 viral viral JJ cord-019051-gtruu1op 562 36 clearance clearance NN cord-019051-gtruu1op 562 37 in in IN cord-019051-gtruu1op 562 38 immunotherapy immunotherapy NN cord-019051-gtruu1op 562 39 of of IN cord-019051-gtruu1op 562 40 respiratory respiratory JJ cord-019051-gtruu1op 562 41 syncytial syncytial JJ cord-019051-gtruu1op 562 42 virus virus NN cord-019051-gtruu1op 562 43 infection infection NN cord-019051-gtruu1op 562 44 of of IN cord-019051-gtruu1op 562 45 cotton cotton NN cord-019051-gtruu1op 562 46 rats rat NNS cord-019051-gtruu1op 562 47 Primary primary JJ cord-019051-gtruu1op 562 48 respiratory respiratory JJ cord-019051-gtruu1op 562 49 syncytial syncytial JJ cord-019051-gtruu1op 562 50 virus virus NN cord-019051-gtruu1op 562 51 infection infection NN cord-019051-gtruu1op 562 52 in in IN cord-019051-gtruu1op 562 53 mice mouse NNS cord-019051-gtruu1op 562 54 Respiratory respiratory JJ cord-019051-gtruu1op 562 55 syncytial syncytial JJ cord-019051-gtruu1op 562 56 virus virus NN cord-019051-gtruu1op 562 57 infection infection NN cord-019051-gtruu1op 562 58 in in IN cord-019051-gtruu1op 562 59 mice mouse NNS cord-019051-gtruu1op 563 1 Intracellular Intracellular NNP cord-019051-gtruu1op 563 2 IFN IFN NNP cord-019051-gtruu1op 563 3 - - HYPH cord-019051-gtruu1op 563 4 gamma gamma JJ cord-019051-gtruu1op 563 5 expression expression NN cord-019051-gtruu1op 563 6 in in IN cord-019051-gtruu1op 563 7 natural natural JJ cord-019051-gtruu1op 563 8 killer killer NN cord-019051-gtruu1op 563 9 cells cell NNS cord-019051-gtruu1op 563 10 precedes precede VBZ cord-019051-gtruu1op 563 11 lung lung NN cord-019051-gtruu1op 563 12 CD8 CD8 NNP cord-019051-gtruu1op 563 13 + + CC cord-019051-gtruu1op 563 14 T T NNP cord-019051-gtruu1op 563 15 cell cell NN cord-019051-gtruu1op 563 16 recruitment recruitment NN cord-019051-gtruu1op 563 17 during during IN cord-019051-gtruu1op 563 18 respiratory respiratory JJ cord-019051-gtruu1op 563 19 syncytial syncytial JJ cord-019051-gtruu1op 563 20 virus virus NN cord-019051-gtruu1op 563 21 infection infection NN cord-019051-gtruu1op 563 22 Immune immune NN cord-019051-gtruu1op 563 23 - - HYPH cord-019051-gtruu1op 563 24 mediated mediate VBN cord-019051-gtruu1op 563 25 disease disease NN cord-019051-gtruu1op 563 26 pathogenesis pathogenesis NN cord-019051-gtruu1op 563 27 in in IN cord-019051-gtruu1op 563 28 respiratory respiratory JJ cord-019051-gtruu1op 563 29 syncytial syncytial JJ cord-019051-gtruu1op 563 30 virus virus NN cord-019051-gtruu1op 563 31 infection infection NN cord-019051-gtruu1op 563 32 Chinchilla Chinchilla NNP cord-019051-gtruu1op 563 33 and and CC cord-019051-gtruu1op 563 34 murine murine JJ cord-019051-gtruu1op 563 35 models model NNS cord-019051-gtruu1op 563 36 of of IN cord-019051-gtruu1op 563 37 upper upper JJ cord-019051-gtruu1op 563 38 respiratory respiratory JJ cord-019051-gtruu1op 563 39 tract tract NN cord-019051-gtruu1op 563 40 infections infection NNS cord-019051-gtruu1op 563 41 with with IN cord-019051-gtruu1op 563 42 respiratory respiratory JJ cord-019051-gtruu1op 563 43 syncytial syncytial JJ cord-019051-gtruu1op 563 44 virus virus NN cord-019051-gtruu1op 563 45 Evaluation evaluation NN cord-019051-gtruu1op 563 46 of of IN cord-019051-gtruu1op 563 47 severe severe JJ cord-019051-gtruu1op 563 48 disease disease NN cord-019051-gtruu1op 563 49 induced induce VBN cord-019051-gtruu1op 563 50 by by IN cord-019051-gtruu1op 563 51 aerosol aerosol NN cord-019051-gtruu1op 563 52 inoculation inoculation NN cord-019051-gtruu1op 563 53 of of IN cord-019051-gtruu1op 563 54 calves calf NNS cord-019051-gtruu1op 563 55 with with IN cord-019051-gtruu1op 563 56 bovine bovine JJ cord-019051-gtruu1op 563 57 respiratory respiratory JJ cord-019051-gtruu1op 563 58 syncytial syncytial JJ cord-019051-gtruu1op 563 59 virus virus NN cord-019051-gtruu1op 563 60 Complete complete JJ cord-019051-gtruu1op 563 61 sequence sequence NN cord-019051-gtruu1op 563 62 of of IN cord-019051-gtruu1op 563 63 the the DT cord-019051-gtruu1op 563 64 RNA RNA NNP cord-019051-gtruu1op 563 65 genome genome NN cord-019051-gtruu1op 563 66 of of IN cord-019051-gtruu1op 563 67 pneumonia pneumonia NN cord-019051-gtruu1op 563 68 virus virus NN cord-019051-gtruu1op 563 69 of of IN cord-019051-gtruu1op 563 70 mice mouse NNS cord-019051-gtruu1op 563 71 ( ( -LRB- cord-019051-gtruu1op 563 72 PVM pvm NN cord-019051-gtruu1op 563 73 ) ) -RRB- cord-019051-gtruu1op 564 1 Parainfluenza Parainfluenza NNP cord-019051-gtruu1op 564 2 viruses virus NNS cord-019051-gtruu1op 565 1 Parainfluenza Parainfluenza NNP cord-019051-gtruu1op 565 2 viruses virus NNS cord-019051-gtruu1op 566 1 Myxoviruses myxovirus NNS cord-019051-gtruu1op 566 2 : : : cord-019051-gtruu1op 567 1 Parainfluenza Parainfluenza NNP cord-019051-gtruu1op 567 2 International International NNP cord-019051-gtruu1op 567 3 Committee Committee NNP cord-019051-gtruu1op 567 4 on on IN cord-019051-gtruu1op 567 5 Taxonomy Taxonomy NNP cord-019051-gtruu1op 567 6 of of IN cord-019051-gtruu1op 567 7 Viruses Viruses NNPS cord-019051-gtruu1op 568 1 The the DT cord-019051-gtruu1op 568 2 role role NN cord-019051-gtruu1op 568 3 of of IN cord-019051-gtruu1op 568 4 viral viral JJ cord-019051-gtruu1op 568 5 glycoproteins glycoprotein NNS cord-019051-gtruu1op 568 6 in in IN cord-019051-gtruu1op 568 7 adsorption adsorption NN cord-019051-gtruu1op 568 8 , , , cord-019051-gtruu1op 568 9 penetration penetration NN cord-019051-gtruu1op 568 10 , , , cord-019051-gtruu1op 568 11 and and CC cord-019051-gtruu1op 568 12 pathogenicity pathogenicity NN cord-019051-gtruu1op 568 13 of of IN cord-019051-gtruu1op 568 14 viruses virus NNS cord-019051-gtruu1op 569 1 New new JJ cord-019051-gtruu1op 569 2 frontiers frontier NNS cord-019051-gtruu1op 569 3 opened open VBN cord-019051-gtruu1op 569 4 by by IN cord-019051-gtruu1op 569 5 the the DT cord-019051-gtruu1op 569 6 exploration exploration NN cord-019051-gtruu1op 569 7 of of IN cord-019051-gtruu1op 569 8 host host NN cord-019051-gtruu1op 569 9 cell cell NN cord-019051-gtruu1op 569 10 receptors receptor NNS cord-019051-gtruu1op 569 11 Acquisition Acquisition NNP cord-019051-gtruu1op 569 12 of of IN cord-019051-gtruu1op 569 13 serum serum NN cord-019051-gtruu1op 569 14 antibodies antibody NNS cord-019051-gtruu1op 569 15 to to IN cord-019051-gtruu1op 569 16 specific specific JJ cord-019051-gtruu1op 569 17 glycoproteins glycoprotein NNS cord-019051-gtruu1op 569 18 of of IN cord-019051-gtruu1op 569 19 parainfluenza parainfluenza NNP cord-019051-gtruu1op 569 20 virus virus NNP cord-019051-gtruu1op 569 21 3 3 CD cord-019051-gtruu1op 569 22 in in IN cord-019051-gtruu1op 569 23 children child NNS cord-019051-gtruu1op 569 24 ) ) -RRB- cord-019051-gtruu1op 569 25 secretory secretory JJ cord-019051-gtruu1op 569 26 immunological immunological JJ cord-019051-gtruu1op 569 27 response response NN cord-019051-gtruu1op 569 28 in in IN cord-019051-gtruu1op 569 29 infants infant NNS cord-019051-gtruu1op 569 30 and and CC cord-019051-gtruu1op 569 31 children child NNS cord-019051-gtruu1op 569 32 to to IN cord-019051-gtruu1op 569 33 parainfluenza parainfluenza NNP cord-019051-gtruu1op 569 34 virus virus NN cord-019051-gtruu1op 569 35 types type NNS cord-019051-gtruu1op 569 36 1 1 CD cord-019051-gtruu1op 569 37 and and CC cord-019051-gtruu1op 569 38 2 2 CD cord-019051-gtruu1op 569 39 Brief brief JJ cord-019051-gtruu1op 569 40 report report NN cord-019051-gtruu1op 569 41 : : : cord-019051-gtruu1op 569 42 Parainfluenza Parainfluenza NNP cord-019051-gtruu1op 569 43 virus virus NN cord-019051-gtruu1op 569 44 type type NN cord-019051-gtruu1op 569 45 3 3 CD cord-019051-gtruu1op 569 46 infections infection NNS cord-019051-gtruu1op 569 47 : : : cord-019051-gtruu1op 570 1 Finding find VBG cord-019051-gtruu1op 570 2 in in IN cord-019051-gtruu1op 570 3 Sydney Sydney NNP cord-019051-gtruu1op 570 4 and and CC cord-019051-gtruu1op 570 5 some some DT cord-019051-gtruu1op 570 6 observations observation NNS cord-019051-gtruu1op 570 7 on on IN cord-019051-gtruu1op 570 8 variations variation NNS cord-019051-gtruu1op 570 9 in in IN cord-019051-gtruu1op 570 10 seasonality seasonality NN cord-019051-gtruu1op 570 11 world world NN cord-019051-gtruu1op 570 12 - - HYPH cord-019051-gtruu1op 570 13 wide wide JJ cord-019051-gtruu1op 570 14 Croup croup NN cord-019051-gtruu1op 570 15 : : : cord-019051-gtruu1op 571 1 An an DT cord-019051-gtruu1op 571 2 11 11 CD cord-019051-gtruu1op 571 3 year year NN cord-019051-gtruu1op 571 4 study study NN cord-019051-gtruu1op 571 5 in in IN cord-019051-gtruu1op 571 6 pediatric pediatric JJ cord-019051-gtruu1op 571 7 practice practice NN cord-019051-gtruu1op 571 8 Viral viral JJ cord-019051-gtruu1op 571 9 croup croup NN cord-019051-gtruu1op 571 10 : : : cord-019051-gtruu1op 571 11 A a DT cord-019051-gtruu1op 571 12 current current JJ cord-019051-gtruu1op 571 13 perspective perspective NN cord-019051-gtruu1op 571 14 Adenoviruses adenovirus NNS cord-019051-gtruu1op 571 15 Worldwide Worldwide NNP cord-019051-gtruu1op 571 16 epidemiology epidemiology NN cord-019051-gtruu1op 571 17 of of IN cord-019051-gtruu1op 571 18 human human JJ cord-019051-gtruu1op 571 19 adenovirus adenovirus NN cord-019051-gtruu1op 571 20 infections infection NNS cord-019051-gtruu1op 571 21 Recovery Recovery NNP cord-019051-gtruu1op 571 22 of of IN cord-019051-gtruu1op 571 23 new new JJ cord-019051-gtruu1op 571 24 agents agent NNS cord-019051-gtruu1op 571 25 from from IN cord-019051-gtruu1op 571 26 patients patient NNS cord-019051-gtruu1op 571 27 with with IN cord-019051-gtruu1op 571 28 acute acute JJ cord-019051-gtruu1op 571 29 respiratory respiratory JJ cord-019051-gtruu1op 571 30 illness illness NN cord-019051-gtruu1op 571 31 Infections infection NNS cord-019051-gtruu1op 571 32 in in IN cord-019051-gtruu1op 571 33 18,000 18,000 CD cord-019051-gtruu1op 571 34 infants infant NNS cord-019051-gtruu1op 571 35 and and CC cord-019051-gtruu1op 571 36 children child NNS cord-019051-gtruu1op 571 37 in in IN cord-019051-gtruu1op 571 38 a a DT cord-019051-gtruu1op 571 39 controlled control VBN cord-019051-gtruu1op 571 40 study study NN cord-019051-gtruu1op 571 41 of of IN cord-019051-gtruu1op 571 42 respiratory respiratory JJ cord-019051-gtruu1op 571 43 tract tract NN cord-019051-gtruu1op 571 44 disease disease NN cord-019051-gtruu1op 571 45 . . . cord-019051-gtruu1op 572 1 I. I. NNP cord-019051-gtruu1op 572 2 Adenovirus Adenovirus NNP cord-019051-gtruu1op 572 3 pathogenicity pathogenicity NN cord-019051-gtruu1op 572 4 in in IN cord-019051-gtruu1op 572 5 relation relation NN cord-019051-gtruu1op 572 6 to to IN cord-019051-gtruu1op 572 7 serologic serologic JJ cord-019051-gtruu1op 572 8 type type NN cord-019051-gtruu1op 572 9 and and CC cord-019051-gtruu1op 572 10 illness illness NN cord-019051-gtruu1op 572 11 syndrome syndrome NN cord-019051-gtruu1op 572 12 International International NNP cord-019051-gtruu1op 572 13 Committee Committee NNP cord-019051-gtruu1op 572 14 on on IN cord-019051-gtruu1op 572 15 Taxonomy Taxonomy NNP cord-019051-gtruu1op 572 16 of of IN cord-019051-gtruu1op 572 17 Viruses Viruses NNPS cord-019051-gtruu1op 573 1 The the DT cord-019051-gtruu1op 573 2 icosahedral icosahedral JJ cord-019051-gtruu1op 573 3 form form NN cord-019051-gtruu1op 573 4 of of IN cord-019051-gtruu1op 573 5 an an DT cord-019051-gtruu1op 573 6 adenovirus adenovirus NN cord-019051-gtruu1op 573 7 Adenoviruses adenovirus NNS cord-019051-gtruu1op 573 8 . . . cord-019051-gtruu1op 574 1 The the DT cord-019051-gtruu1op 574 2 viruses virus NNS cord-019051-gtruu1op 574 3 and and CC cord-019051-gtruu1op 574 4 their -PRON- PRP$ cord-019051-gtruu1op 574 5 replication replication NN cord-019051-gtruu1op 574 6 Adenovirus Adenovirus NNP cord-019051-gtruu1op 574 7 : : : cord-019051-gtruu1op 575 1 From from IN cord-019051-gtruu1op 575 2 foe foe NN cord-019051-gtruu1op 575 3 to to IN cord-019051-gtruu1op 575 4 friend friend NN cord-019051-gtruu1op 576 1 A a DT cord-019051-gtruu1op 576 2 proposed propose VBN cord-019051-gtruu1op 576 3 terminology terminology NN cord-019051-gtruu1op 576 4 for for IN cord-019051-gtruu1op 576 5 the the DT cord-019051-gtruu1op 576 6 adenovirus adenovirus NN cord-019051-gtruu1op 576 7 antigens antigen NNS cord-019051-gtruu1op 576 8 and and CC cord-019051-gtruu1op 576 9 virion virion NN cord-019051-gtruu1op 576 10 morphological morphological JJ cord-019051-gtruu1op 576 11 subunits subunit NNS cord-019051-gtruu1op 576 12 Human human JJ cord-019051-gtruu1op 576 13 adenovirus adenovirus NN cord-019051-gtruu1op 577 1 C C NNP cord-019051-gtruu1op 578 1 The the DT cord-019051-gtruu1op 578 2 molecular molecular JJ cord-019051-gtruu1op 578 3 composition composition NN cord-019051-gtruu1op 578 4 of of IN cord-019051-gtruu1op 578 5 the the DT cord-019051-gtruu1op 578 6 adenovirus adenovirus NN cord-019051-gtruu1op 578 7 type type NN cord-019051-gtruu1op 578 8 2 2 CD cord-019051-gtruu1op 578 9 virion virion NN cord-019051-gtruu1op 578 10 CD46 CD46 NNP cord-019051-gtruu1op 578 11 is be VBZ cord-019051-gtruu1op 578 12 a a DT cord-019051-gtruu1op 578 13 cellular cellular JJ cord-019051-gtruu1op 578 14 receptor receptor NN cord-019051-gtruu1op 578 15 for for IN cord-019051-gtruu1op 578 16 all all DT cord-019051-gtruu1op 578 17 species specie NNS cord-019051-gtruu1op 579 1 B b NN cord-019051-gtruu1op 579 2 adenoviruses adenovirus NNS cord-019051-gtruu1op 579 3 except except IN cord-019051-gtruu1op 579 4 types type NNS cord-019051-gtruu1op 579 5 3 3 CD cord-019051-gtruu1op 579 6 and and CC cord-019051-gtruu1op 579 7 7 7 CD cord-019051-gtruu1op 579 8 Transcriptional Transcriptional NNP cord-019051-gtruu1op 579 9 and and CC cord-019051-gtruu1op 579 10 transforming transform VBG cord-019051-gtruu1op 579 11 activities activity NNS cord-019051-gtruu1op 579 12 of of IN cord-019051-gtruu1op 579 13 the the DT cord-019051-gtruu1op 579 14 adenovirus adenovirus NN cord-019051-gtruu1op 579 15 E1A e1a NN cord-019051-gtruu1op 579 16 proteins protein NNS cord-019051-gtruu1op 579 17 Latent latent JJ cord-019051-gtruu1op 579 18 adenovirus adenovirus NN cord-019051-gtruu1op 579 19 infection infection NN cord-019051-gtruu1op 579 20 in in IN cord-019051-gtruu1op 579 21 COPD COPD NNP cord-019051-gtruu1op 579 22 Relations Relations NNPS cord-019051-gtruu1op 579 23 of of IN cord-019051-gtruu1op 579 24 the the DT cord-019051-gtruu1op 579 25 new new JJ cord-019051-gtruu1op 579 26 respiratory respiratory JJ cord-019051-gtruu1op 579 27 agents agent NNS cord-019051-gtruu1op 579 28 to to TO cord-019051-gtruu1op 579 29 acute acute JJ cord-019051-gtruu1op 579 30 respiratory respiratory JJ cord-019051-gtruu1op 579 31 diseases disease NNS cord-019051-gtruu1op 579 32 Adenovirus Adenovirus NNP cord-019051-gtruu1op 579 33 infections infection NNS cord-019051-gtruu1op 579 34 and and CC cord-019051-gtruu1op 579 35 lung lung NN cord-019051-gtruu1op 579 36 disease disease NN cord-019051-gtruu1op 580 1 In in IN cord-019051-gtruu1op 580 2 situ situ JJ cord-019051-gtruu1op 580 3 hybridization hybridization NN cord-019051-gtruu1op 580 4 studies study NNS cord-019051-gtruu1op 580 5 of of IN cord-019051-gtruu1op 580 6 adenoviral adenoviral JJ cord-019051-gtruu1op 580 7 infections infection NNS cord-019051-gtruu1op 580 8 of of IN cord-019051-gtruu1op 580 9 the the DT cord-019051-gtruu1op 580 10 lung lung NN cord-019051-gtruu1op 580 11 and and CC cord-019051-gtruu1op 580 12 their -PRON- PRP$ cord-019051-gtruu1op 580 13 relationship relationship NN cord-019051-gtruu1op 580 14 to to IN cord-019051-gtruu1op 580 15 follicular follicular JJ cord-019051-gtruu1op 580 16 bronchiectasis bronchiectasis NN cord-019051-gtruu1op 580 17 Histopathology Histopathology NNP cord-019051-gtruu1op 580 18 of of IN cord-019051-gtruu1op 580 19 adenovirus adenovirus NN cord-019051-gtruu1op 580 20 infection infection NN cord-019051-gtruu1op 580 21 of of IN cord-019051-gtruu1op 580 22 the the DT cord-019051-gtruu1op 580 23 respiratory respiratory JJ cord-019051-gtruu1op 580 24 tract tract NN cord-019051-gtruu1op 580 25 in in IN cord-019051-gtruu1op 580 26 young young JJ cord-019051-gtruu1op 580 27 children child NNS cord-019051-gtruu1op 580 28 Severe severe JJ cord-019051-gtruu1op 580 29 adenovirus adenovirus NN cord-019051-gtruu1op 580 30 bronchiolitis bronchiolitis NN cord-019051-gtruu1op 580 31 in in IN cord-019051-gtruu1op 580 32 children child NNS cord-019051-gtruu1op 581 1 Latent latent JJ cord-019051-gtruu1op 581 2 adenoviral adenoviral JJ cord-019051-gtruu1op 581 3 infection infection NN cord-019051-gtruu1op 581 4 in in IN cord-019051-gtruu1op 581 5 the the DT cord-019051-gtruu1op 581 6 pathogenesis pathogenesis NN cord-019051-gtruu1op 581 7 of of IN cord-019051-gtruu1op 581 8 chronic chronic JJ cord-019051-gtruu1op 581 9 airways airways NNP cord-019051-gtruu1op 581 10 obstruction obstruction NN cord-019051-gtruu1op 581 11 Immunodetection Immunodetection NNP cord-019051-gtruu1op 581 12 of of IN cord-019051-gtruu1op 581 13 adenoviral adenoviral JJ cord-019051-gtruu1op 581 14 E1A e1a NN cord-019051-gtruu1op 581 15 proteins protein NNS cord-019051-gtruu1op 581 16 in in IN cord-019051-gtruu1op 581 17 human human JJ cord-019051-gtruu1op 581 18 lung lung NN cord-019051-gtruu1op 581 19 tissue tissue NN cord-019051-gtruu1op 581 20 Amplification amplification NN cord-019051-gtruu1op 581 21 of of IN cord-019051-gtruu1op 581 22 inflammation inflammation NN cord-019051-gtruu1op 581 23 in in IN cord-019051-gtruu1op 581 24 emphysema emphysema NN cord-019051-gtruu1op 581 25 and and CC cord-019051-gtruu1op 581 26 its -PRON- PRP$ cord-019051-gtruu1op 581 27 association association NN cord-019051-gtruu1op 581 28 with with IN cord-019051-gtruu1op 581 29 latent latent JJ cord-019051-gtruu1op 581 30 adenoviral adenoviral NNP cord-019051-gtruu1op 581 31 infection infection NN cord-019051-gtruu1op 582 1 Latent latent JJ cord-019051-gtruu1op 582 2 adenoviral adenoviral JJ cord-019051-gtruu1op 582 3 infection infection NN cord-019051-gtruu1op 582 4 induces induce VBZ cord-019051-gtruu1op 582 5 production production NN cord-019051-gtruu1op 582 6 of of IN cord-019051-gtruu1op 582 7 growth growth NN cord-019051-gtruu1op 582 8 factors factor NNS cord-019051-gtruu1op 582 9 relevant relevant JJ cord-019051-gtruu1op 582 10 to to IN cord-019051-gtruu1op 582 11 airway airway NN cord-019051-gtruu1op 582 12 remodeling remodeling NN cord-019051-gtruu1op 582 13 in in IN cord-019051-gtruu1op 582 14 COPD COPD NNP cord-019051-gtruu1op 583 1 The the DT cord-019051-gtruu1op 583 2 nature nature NN cord-019051-gtruu1op 583 3 of of IN cord-019051-gtruu1op 583 4 small small JJ cord-019051-gtruu1op 583 5 airway airway JJ cord-019051-gtruu1op 583 6 obstruction obstruction NN cord-019051-gtruu1op 583 7 in in IN cord-019051-gtruu1op 583 8 chronic chronic JJ cord-019051-gtruu1op 583 9 obstructive obstructive JJ cord-019051-gtruu1op 583 10 pulmonary pulmonary JJ cord-019051-gtruu1op 583 11 disease disease NN cord-019051-gtruu1op 584 1 Adenoidalpharyngeal adenoidalpharyngeal JJ cord-019051-gtruu1op 584 2 - - HYPH cord-019051-gtruu1op 584 3 conjunctival conjunctival NN cord-019051-gtruu1op 584 4 agents agent NNS cord-019051-gtruu1op 584 5 : : : cord-019051-gtruu1op 585 1 A a DT cord-019051-gtruu1op 585 2 newly newly RB cord-019051-gtruu1op 585 3 recognized recognize VBN cord-019051-gtruu1op 585 4 group group NN cord-019051-gtruu1op 585 5 of of IN cord-019051-gtruu1op 585 6 common common JJ cord-019051-gtruu1op 585 7 viruses virus NNS cord-019051-gtruu1op 585 8 of of IN cord-019051-gtruu1op 585 9 the the DT cord-019051-gtruu1op 585 10 respiratory respiratory JJ cord-019051-gtruu1op 585 11 system system NN cord-019051-gtruu1op 586 1 A a DT cord-019051-gtruu1op 586 2 study study NN cord-019051-gtruu1op 586 3 of of IN cord-019051-gtruu1op 586 4 illness illness NN cord-019051-gtruu1op 586 5 in in IN cord-019051-gtruu1op 586 6 a a DT cord-019051-gtruu1op 586 7 group group NN cord-019051-gtruu1op 586 8 of of IN cord-019051-gtruu1op 586 9 Cleveland Cleveland NNP cord-019051-gtruu1op 586 10 families family NNS cord-019051-gtruu1op 586 11 . . . cord-019051-gtruu1op 587 1 X. X. NNP cord-019051-gtruu1op 588 1 The the DT cord-019051-gtruu1op 588 2 occurrence occurrence NN cord-019051-gtruu1op 588 3 of of IN cord-019051-gtruu1op 588 4 adenovirus adenovirus NN cord-019051-gtruu1op 588 5 infections infection NNS cord-019051-gtruu1op 588 6 Immunization Immunization NNP cord-019051-gtruu1op 588 7 with with IN cord-019051-gtruu1op 588 8 live live JJ cord-019051-gtruu1op 588 9 types type NNS cord-019051-gtruu1op 588 10 7 7 CD cord-019051-gtruu1op 588 11 and and CC cord-019051-gtruu1op 588 12 4 4 CD cord-019051-gtruu1op 588 13 adenovirus adenovirus NN cord-019051-gtruu1op 588 14 vaccines vaccine NNS cord-019051-gtruu1op 588 15 . . . cord-019051-gtruu1op 589 1 II II NNP cord-019051-gtruu1op 589 2 . . . cord-019051-gtruu1op 590 1 Antibody antibody NN cord-019051-gtruu1op 590 2 response response NN cord-019051-gtruu1op 590 3 and and CC cord-019051-gtruu1op 590 4 protective protective JJ cord-019051-gtruu1op 590 5 effect effect NN cord-019051-gtruu1op 590 6 against against IN cord-019051-gtruu1op 590 7 acute acute JJ cord-019051-gtruu1op 590 8 respiratory respiratory JJ cord-019051-gtruu1op 590 9 disease disease NN cord-019051-gtruu1op 590 10 due due JJ cord-019051-gtruu1op 590 11 to to IN cord-019051-gtruu1op 590 12 adenovirus adenovirus NN cord-019051-gtruu1op 590 13 type type NN cord-019051-gtruu1op 590 14 7 7 CD cord-019051-gtruu1op 590 15 A a DT cord-019051-gtruu1op 590 16 newly newly RB cord-019051-gtruu1op 590 17 discovered discover VBN cord-019051-gtruu1op 590 18 human human JJ cord-019051-gtruu1op 590 19 pneumovirus pneumovirus NNP cord-019051-gtruu1op 590 20 isolated isolate VBN cord-019051-gtruu1op 590 21 from from IN cord-019051-gtruu1op 590 22 young young JJ cord-019051-gtruu1op 590 23 children child NNS cord-019051-gtruu1op 590 24 with with IN cord-019051-gtruu1op 590 25 respiratory respiratory JJ cord-019051-gtruu1op 590 26 tract tract NN cord-019051-gtruu1op 590 27 disease disease NN cord-019051-gtruu1op 590 28 Human Human NNP cord-019051-gtruu1op 590 29 metapneumovirus metapneumovirus NNP cord-019051-gtruu1op 590 30 International International NNP cord-019051-gtruu1op 590 31 Committee Committee NNP cord-019051-gtruu1op 590 32 on on IN cord-019051-gtruu1op 590 33 Taxonomy Taxonomy NNP cord-019051-gtruu1op 590 34 of of IN cord-019051-gtruu1op 590 35 Viruses Viruses NNPS cord-019051-gtruu1op 590 36 Characterization Characterization NNP cord-019051-gtruu1op 590 37 of of IN cord-019051-gtruu1op 590 38 human human JJ cord-019051-gtruu1op 590 39 metapneumoviruses metapneumoviruse NNS cord-019051-gtruu1op 590 40 isolated isolate VBN cord-019051-gtruu1op 590 41 from from IN cord-019051-gtruu1op 590 42 patients patient NNS cord-019051-gtruu1op 590 43 in in IN cord-019051-gtruu1op 590 44 North North NNP cord-019051-gtruu1op 590 45 America America NNP cord-019051-gtruu1op 590 46 Global Global NNP cord-019051-gtruu1op 590 47 genetic genetic JJ cord-019051-gtruu1op 590 48 diversity diversity NN cord-019051-gtruu1op 590 49 of of IN cord-019051-gtruu1op 590 50 human human JJ cord-019051-gtruu1op 590 51 metapneumovirus metapneumovirus NNP cord-019051-gtruu1op 590 52 fusion fusion NN cord-019051-gtruu1op 590 53 gene gene NN cord-019051-gtruu1op 590 54 Use Use NNP cord-019051-gtruu1op 590 55 of of IN cord-019051-gtruu1op 590 56 the the DT cord-019051-gtruu1op 590 57 P p NN cord-019051-gtruu1op 590 58 gene gene NN cord-019051-gtruu1op 590 59 to to IN cord-019051-gtruu1op 590 60 genotype genotype NNP cord-019051-gtruu1op 590 61 human human JJ cord-019051-gtruu1op 590 62 metapneumovirus metapneumovirus NNP cord-019051-gtruu1op 590 63 identifies identify VBZ cord-019051-gtruu1op 590 64 4 4 CD cord-019051-gtruu1op 590 65 viral viral JJ cord-019051-gtruu1op 590 66 subtypes subtype NNS cord-019051-gtruu1op 590 67 Analysis Analysis NNP cord-019051-gtruu1op 590 68 of of IN cord-019051-gtruu1op 590 69 the the DT cord-019051-gtruu1op 590 70 genomic genomic JJ cord-019051-gtruu1op 590 71 sequence sequence NN cord-019051-gtruu1op 590 72 of of IN cord-019051-gtruu1op 590 73 a a DT cord-019051-gtruu1op 590 74 human human JJ cord-019051-gtruu1op 590 75 metapneumovirus metapneumovirus NN cord-019051-gtruu1op 590 76 Respiratory respiratory JJ cord-019051-gtruu1op 590 77 syncytial syncytial JJ cord-019051-gtruu1op 590 78 virus virus NN cord-019051-gtruu1op 590 79 and and CC cord-019051-gtruu1op 590 80 parainfluenzavirus parainfluenzavirus NNP cord-019051-gtruu1op 590 81 Individual individual JJ cord-019051-gtruu1op 590 82 contributions contribution NNS cord-019051-gtruu1op 590 83 of of IN cord-019051-gtruu1op 590 84 the the DT cord-019051-gtruu1op 590 85 human human JJ cord-019051-gtruu1op 590 86 metapneumovirus metapneumovirus NNP cord-019051-gtruu1op 590 87 F F NNP cord-019051-gtruu1op 590 88 , , , cord-019051-gtruu1op 590 89 G G NNP cord-019051-gtruu1op 590 90 , , , cord-019051-gtruu1op 590 91 and and CC cord-019051-gtruu1op 590 92 SH sh NN cord-019051-gtruu1op 590 93 surface surface NN cord-019051-gtruu1op 590 94 glycoproteins glycoprotein NNS cord-019051-gtruu1op 590 95 to to IN cord-019051-gtruu1op 590 96 the the DT cord-019051-gtruu1op 590 97 induction induction NN cord-019051-gtruu1op 590 98 of of IN cord-019051-gtruu1op 590 99 neutralizing neutralize VBG cord-019051-gtruu1op 590 100 antibodies antibody NNS cord-019051-gtruu1op 590 101 and and CC cord-019051-gtruu1op 590 102 protective protective JJ cord-019051-gtruu1op 590 103 immunity immunity NN cord-019051-gtruu1op 590 104 Human Human NNP cord-019051-gtruu1op 590 105 metapneumovirus metapneumovirus NN cord-019051-gtruu1op 590 106 and and CC cord-019051-gtruu1op 590 107 lower low JJR cord-019051-gtruu1op 590 108 respiratory respiratory JJ cord-019051-gtruu1op 590 109 tract tract NN cord-019051-gtruu1op 590 110 disease disease NN cord-019051-gtruu1op 590 111 in in IN cord-019051-gtruu1op 590 112 otherwise otherwise RB cord-019051-gtruu1op 590 113 healthy healthy JJ cord-019051-gtruu1op 590 114 infants infant NNS cord-019051-gtruu1op 590 115 and and CC cord-019051-gtruu1op 590 116 children child NNS cord-019051-gtruu1op 590 117 Detection detection NN cord-019051-gtruu1op 590 118 of of IN cord-019051-gtruu1op 590 119 severe severe JJ cord-019051-gtruu1op 590 120 human human JJ cord-019051-gtruu1op 590 121 metapneumovirus metapneumovirus NN cord-019051-gtruu1op 590 122 infection infection NN cord-019051-gtruu1op 590 123 by by IN cord-019051-gtruu1op 590 124 real real JJ cord-019051-gtruu1op 590 125 - - HYPH cord-019051-gtruu1op 590 126 time time NN cord-019051-gtruu1op 590 127 polymerase polymerase NN cord-019051-gtruu1op 590 128 chain chain NN cord-019051-gtruu1op 590 129 reaction reaction NN cord-019051-gtruu1op 590 130 and and CC cord-019051-gtruu1op 590 131 histopathological histopathological NNP cord-019051-gtruu1op 590 132 assessment assessment NNP cord-019051-gtruu1op 590 133 Human Human NNP cord-019051-gtruu1op 590 134 metapneumovirus metapneumovirus NNP cord-019051-gtruu1op 590 135 infections infection NNS cord-019051-gtruu1op 590 136 in in IN cord-019051-gtruu1op 590 137 hospitalized hospitalize VBN cord-019051-gtruu1op 590 138 children child NNS cord-019051-gtruu1op 590 139 Brief brief JJ cord-019051-gtruu1op 590 140 communication communication NN cord-019051-gtruu1op 590 141 : : : cord-019051-gtruu1op 590 142 Fatal fatal JJ cord-019051-gtruu1op 590 143 human human JJ cord-019051-gtruu1op 590 144 metapneumovirus metapneumovirus NN cord-019051-gtruu1op 590 145 infection infection NN cord-019051-gtruu1op 590 146 in in IN cord-019051-gtruu1op 590 147 stem stem NN cord-019051-gtruu1op 590 148 - - HYPH cord-019051-gtruu1op 590 149 cell cell NN cord-019051-gtruu1op 590 150 transplant transplant NN cord-019051-gtruu1op 590 151 recipients recipient NNS cord-019051-gtruu1op 590 152 Human Human NNP cord-019051-gtruu1op 590 153 metapneumovirus metapneumovirus NNP cord-019051-gtruu1op 590 154 Perspective Perspective NNP cord-019051-gtruu1op 590 155 on on IN cord-019051-gtruu1op 590 156 the the DT cord-019051-gtruu1op 590 157 host host NN cord-019051-gtruu1op 590 158 response response NN cord-019051-gtruu1op 590 159 to to IN cord-019051-gtruu1op 590 160 human human JJ cord-019051-gtruu1op 590 161 metapneumovirus metapneumovirus JJ cord-019051-gtruu1op 590 162 infection infection NN cord-019051-gtruu1op 590 163 : : : cord-019051-gtruu1op 590 164 What what WP cord-019051-gtruu1op 590 165 can can MD cord-019051-gtruu1op 590 166 we -PRON- PRP cord-019051-gtruu1op 590 167 learn learn VB cord-019051-gtruu1op 590 168 from from IN cord-019051-gtruu1op 590 169 respiratory respiratory JJ cord-019051-gtruu1op 590 170 syncytial syncytial JJ cord-019051-gtruu1op 590 171 virus virus NN cord-019051-gtruu1op 590 172 infections infection NNS cord-019051-gtruu1op 590 173 ? ? . cord-019051-gtruu1op 591 1 Epidemiology epidemiology NN cord-019051-gtruu1op 591 2 of of IN cord-019051-gtruu1op 591 3 human human JJ cord-019051-gtruu1op 591 4 metapneumovirus metapneumovirus NN cord-019051-gtruu1op 591 5 Comparison comparison NN cord-019051-gtruu1op 591 6 of of IN cord-019051-gtruu1op 591 7 the the DT cord-019051-gtruu1op 591 8 inhibition inhibition NN cord-019051-gtruu1op 591 9 of of IN cord-019051-gtruu1op 591 10 human human JJ cord-019051-gtruu1op 591 11 metapneumovirus metapneumovirus NNP cord-019051-gtruu1op 591 12 and and CC cord-019051-gtruu1op 591 13 human human JJ cord-019051-gtruu1op 591 14 respiratory respiratory JJ cord-019051-gtruu1op 591 15 syncytial syncytial JJ cord-019051-gtruu1op 591 16 virus virus NN cord-019051-gtruu1op 591 17 by by IN cord-019051-gtruu1op 591 18 ribavirin ribavirin NN cord-019051-gtruu1op 591 19 and and CC cord-019051-gtruu1op 591 20 immune immune JJ cord-019051-gtruu1op 591 21 serum serum NN cord-019051-gtruu1op 591 22 globulin globulin NN cord-019051-gtruu1op 592 1 In in IN cord-019051-gtruu1op 592 2 vitro vitro FW cord-019051-gtruu1op 592 3 Isolation isolation NN cord-019051-gtruu1op 592 4 and and CC cord-019051-gtruu1op 592 5 characterization characterization NN cord-019051-gtruu1op 592 6 of of IN cord-019051-gtruu1op 592 7 monoclonal monoclonal JJ cord-019051-gtruu1op 592 8 antibodies antibody NNS cord-019051-gtruu1op 592 9 which which WDT cord-019051-gtruu1op 592 10 neutralize neutralize VBP cord-019051-gtruu1op 592 11 human human JJ cord-019051-gtruu1op 592 12 metapneumovirus metapneumovirus NN cord-019051-gtruu1op 593 1 In in IN cord-019051-gtruu1op 593 2 vitro vitro FW cord-019051-gtruu1op 593 3 and and CC cord-019051-gtruu1op 593 4 in in IN cord-019051-gtruu1op 593 5 vivo vivo NN cord-019051-gtruu1op 593 6 Cloning cloning NN cord-019051-gtruu1op 593 7 of of IN cord-019051-gtruu1op 593 8 a a DT cord-019051-gtruu1op 593 9 human human JJ cord-019051-gtruu1op 593 10 parvovirus parvovirus NN cord-019051-gtruu1op 593 11 by by IN cord-019051-gtruu1op 593 12 molecular molecular JJ cord-019051-gtruu1op 593 13 screening screening NN cord-019051-gtruu1op 593 14 of of IN cord-019051-gtruu1op 593 15 respiratory respiratory JJ cord-019051-gtruu1op 593 16 tract tract NN cord-019051-gtruu1op 593 17 samples sample NNS cord-019051-gtruu1op 593 18 Human Human NNP cord-019051-gtruu1op 593 19 Bocavirus Bocavirus NNP cord-019051-gtruu1op 593 20 -A -A HYPH cord-019051-gtruu1op 593 21 novel novel JJ cord-019051-gtruu1op 593 22 parvovirus parvovirus NN cord-019051-gtruu1op 593 23 to to TO cord-019051-gtruu1op 593 24 infect infect VB cord-019051-gtruu1op 593 25 humans human NNS cord-019051-gtruu1op 593 26 Seroepidemiology Seroepidemiology NNP cord-019051-gtruu1op 593 27 of of IN cord-019051-gtruu1op 593 28 human human JJ cord-019051-gtruu1op 593 29 bocavirus bocavirus NN cord-019051-gtruu1op 593 30 in in IN cord-019051-gtruu1op 593 31 Hokkaido Hokkaido NNP cord-019051-gtruu1op 593 32 prefecture prefecture NN cord-019051-gtruu1op 593 33 Complete complete JJ cord-019051-gtruu1op 593 34 coding coding NN cord-019051-gtruu1op 593 35 sequences sequence NNS cord-019051-gtruu1op 593 36 and and CC cord-019051-gtruu1op 593 37 phylogenetic phylogenetic JJ cord-019051-gtruu1op 593 38 analysis analysis NN cord-019051-gtruu1op 593 39 of of IN cord-019051-gtruu1op 593 40 human human JJ cord-019051-gtruu1op 593 41 bocavirus bocavirus NNP cord-019051-gtruu1op 593 42 ( ( -LRB- cord-019051-gtruu1op 593 43 HBoV HBoV NNP cord-019051-gtruu1op 593 44 ) ) -RRB- cord-019051-gtruu1op 593 45 Human human JJ cord-019051-gtruu1op 593 46 bocavirus bocavirus NN cord-019051-gtruu1op 593 47 infection infection NN cord-019051-gtruu1op 593 48 , , , cord-019051-gtruu1op 593 49 People People NNPS cord-019051-gtruu1op 593 50 's 's POS cord-019051-gtruu1op 593 51 Republic Republic NNP cord-019051-gtruu1op 593 52 of of IN cord-019051-gtruu1op 593 53 China China NNP cord-019051-gtruu1op 593 54 Human Human NNP cord-019051-gtruu1op 593 55 bocavirus bocavirus NN cord-019051-gtruu1op 593 56 : : : cord-019051-gtruu1op 593 57 Prevalence prevalence NN cord-019051-gtruu1op 593 58 and and CC cord-019051-gtruu1op 593 59 clinical clinical JJ cord-019051-gtruu1op 593 60 spectrum spectrum NN cord-019051-gtruu1op 593 61 at at IN cord-019051-gtruu1op 593 62 a a DT cord-019051-gtruu1op 593 63 children child NNS cord-019051-gtruu1op 593 64 's 's POS cord-019051-gtruu1op 593 65 hospital hospital NN cord-019051-gtruu1op 593 66 High high JJ cord-019051-gtruu1op 593 67 rate rate NN cord-019051-gtruu1op 593 68 of of IN cord-019051-gtruu1op 593 69 human human JJ cord-019051-gtruu1op 593 70 bocavirus bocavirus NN cord-019051-gtruu1op 593 71 and and CC cord-019051-gtruu1op 593 72 adenovirus adenovirus NN cord-019051-gtruu1op 593 73 co co NN cord-019051-gtruu1op 593 74 - - NN cord-019051-gtruu1op 593 75 infection infection NN cord-019051-gtruu1op 593 76 in in IN cord-019051-gtruu1op 593 77 hospitalized hospitalize VBN cord-019051-gtruu1op 593 78 Israeli israeli JJ cord-019051-gtruu1op 593 79 children child NNS cord-019051-gtruu1op 593 80 CD4 CD4 NNP cord-019051-gtruu1op 593 81 + + CC cord-019051-gtruu1op 593 82 T t NN cord-019051-gtruu1op 593 83 helper helper NN cord-019051-gtruu1op 593 84 cell cell NN cord-019051-gtruu1op 593 85 responses response NNS cord-019051-gtruu1op 593 86 against against IN cord-019051-gtruu1op 593 87 human human JJ cord-019051-gtruu1op 593 88 bocavirus bocavirus NNP cord-019051-gtruu1op 593 89 VP2 VP2 NNP cord-019051-gtruu1op 593 90 virus virus NN cord-019051-gtruu1op 593 91 - - HYPH cord-019051-gtruu1op 593 92 like like JJ cord-019051-gtruu1op 593 93 particles particle NNS cord-019051-gtruu1op 593 94 in in IN cord-019051-gtruu1op 593 95 healthy healthy JJ cord-019051-gtruu1op 593 96 adults adult NNS cord-019051-gtruu1op 593 97 Development Development NNP cord-019051-gtruu1op 593 98 of of IN cord-019051-gtruu1op 593 99 real real JJ cord-019051-gtruu1op 593 100 time time NN cord-019051-gtruu1op 593 101 PCR pcr NN cord-019051-gtruu1op 593 102 assays assay NNS cord-019051-gtruu1op 593 103 for for IN cord-019051-gtruu1op 593 104 detection detection NN cord-019051-gtruu1op 593 105 and and CC cord-019051-gtruu1op 593 106 quantification quantification NN cord-019051-gtruu1op 593 107 of of IN cord-019051-gtruu1op 593 108 human human JJ cord-019051-gtruu1op 593 109 bocavirus bocavirus NNP cord-019051-gtruu1op 593 110 Coronaviruses Coronaviruses NNPS cord-019051-gtruu1op 593 111 . . . cord-019051-gtruu1op 594 1 In in IN cord-019051-gtruu1op 594 2 : : : cord-019051-gtruu1op 594 3 BN BN NNP cord-019051-gtruu1op 594 4 Fields Fields NNP cord-019051-gtruu1op 594 5 Cultivation Cultivation NNP cord-019051-gtruu1op 594 6 of of IN cord-019051-gtruu1op 594 7 a a DT cord-019051-gtruu1op 594 8 novel novel JJ cord-019051-gtruu1op 594 9 type type NN cord-019051-gtruu1op 594 10 of of IN cord-019051-gtruu1op 594 11 common common JJ cord-019051-gtruu1op 594 12 - - HYPH cord-019051-gtruu1op 594 13 cold cold JJ cord-019051-gtruu1op 594 14 virus virus NN cord-019051-gtruu1op 594 15 in in IN cord-019051-gtruu1op 594 16 organ organ NN cord-019051-gtruu1op 594 17 cultures culture NNS cord-019051-gtruu1op 595 1 A a DT cord-019051-gtruu1op 595 2 new new JJ cord-019051-gtruu1op 595 3 virus virus NN cord-019051-gtruu1op 595 4 isolated isolate VBN cord-019051-gtruu1op 595 5 from from IN cord-019051-gtruu1op 595 6 the the DT cord-019051-gtruu1op 595 7 human human JJ cord-019051-gtruu1op 595 8 respiratory respiratory JJ cord-019051-gtruu1op 595 9 tract tract NN cord-019051-gtruu1op 595 10 Recovery recovery NN cord-019051-gtruu1op 595 11 in in IN cord-019051-gtruu1op 595 12 tracheal tracheal JJ cord-019051-gtruu1op 595 13 organ organ NN cord-019051-gtruu1op 595 14 cultures culture NNS cord-019051-gtruu1op 595 15 of of IN cord-019051-gtruu1op 595 16 novel novel NN cord-019051-gtruu1op 595 17 viruses virus NNS cord-019051-gtruu1op 595 18 from from IN cord-019051-gtruu1op 595 19 patients patient NNS cord-019051-gtruu1op 595 20 with with IN cord-019051-gtruu1op 595 21 respiratory respiratory JJ cord-019051-gtruu1op 595 22 disease disease NN cord-019051-gtruu1op 595 23 Identification identification NN cord-019051-gtruu1op 595 24 of of IN cord-019051-gtruu1op 595 25 a a DT cord-019051-gtruu1op 595 26 novel novel JJ cord-019051-gtruu1op 595 27 coronavirus coronavirus NN cord-019051-gtruu1op 595 28 in in IN cord-019051-gtruu1op 595 29 patients patient NNS cord-019051-gtruu1op 595 30 with with IN cord-019051-gtruu1op 595 31 acute acute JJ cord-019051-gtruu1op 595 32 respiratory respiratory JJ cord-019051-gtruu1op 595 33 syndrome syndrome NN cord-019051-gtruu1op 596 1 A a DT cord-019051-gtruu1op 596 2 novel novel JJ cord-019051-gtruu1op 596 3 coronavirus coronavirus NN cord-019051-gtruu1op 596 4 associated associate VBN cord-019051-gtruu1op 596 5 with with IN cord-019051-gtruu1op 596 6 severe severe JJ cord-019051-gtruu1op 596 7 acute acute JJ cord-019051-gtruu1op 596 8 respiratory respiratory JJ cord-019051-gtruu1op 596 9 syndrome syndrome NN cord-019051-gtruu1op 596 10 Identification identification NN cord-019051-gtruu1op 596 11 of of IN cord-019051-gtruu1op 596 12 a a DT cord-019051-gtruu1op 596 13 new new JJ cord-019051-gtruu1op 596 14 human human JJ cord-019051-gtruu1op 596 15 coronavirus coronavirus NN cord-019051-gtruu1op 596 16 Characterization characterization NN cord-019051-gtruu1op 596 17 and and CC cord-019051-gtruu1op 596 18 complete complete JJ cord-019051-gtruu1op 596 19 genome genome NN cord-019051-gtruu1op 596 20 sequence sequence NN cord-019051-gtruu1op 596 21 of of IN cord-019051-gtruu1op 596 22 a a DT cord-019051-gtruu1op 596 23 novel novel JJ cord-019051-gtruu1op 596 24 coronavirus coronavirus NN cord-019051-gtruu1op 596 25 , , , cord-019051-gtruu1op 596 26 coronavirus coronavirus NN cord-019051-gtruu1op 596 27 HKU1 HKU1 NNP cord-019051-gtruu1op 596 28 , , , cord-019051-gtruu1op 596 29 from from IN cord-019051-gtruu1op 596 30 patients patient NNS cord-019051-gtruu1op 596 31 with with IN cord-019051-gtruu1op 596 32 pneumonia pneumonia NN cord-019051-gtruu1op 596 33 International International NNP cord-019051-gtruu1op 596 34 Committee Committee NNP cord-019051-gtruu1op 596 35 on on IN cord-019051-gtruu1op 596 36 Taxonomy Taxonomy NNP cord-019051-gtruu1op 596 37 of of IN cord-019051-gtruu1op 596 38 Viruses Viruses NNP cord-019051-gtruu1op 596 39 Coronaviridae Coronaviridae NNP cord-019051-gtruu1op 596 40 : : : cord-019051-gtruu1op 596 41 A a DT cord-019051-gtruu1op 596 42 review review NN cord-019051-gtruu1op 596 43 of of IN cord-019051-gtruu1op 596 44 coronaviruses coronaviruse NNS cord-019051-gtruu1op 596 45 and and CC cord-019051-gtruu1op 596 46 torovirus torovirus NNP cord-019051-gtruu1op 597 1 The the DT cord-019051-gtruu1op 597 2 coronavirus coronavirus NN cord-019051-gtruu1op 597 3 surface surface NN cord-019051-gtruu1op 597 4 glycoprotein glycoprotein NN cord-019051-gtruu1op 597 5 The the DT cord-019051-gtruu1op 597 6 coronavirus coronavirus NN cord-019051-gtruu1op 597 7 membrane membrane NN cord-019051-gtruu1op 597 8 glycoprotein glycoprotein NN cord-019051-gtruu1op 597 9 The the DT cord-019051-gtruu1op 597 10 small small JJ cord-019051-gtruu1op 597 11 membrane membrane NN cord-019051-gtruu1op 597 12 protein protein NN cord-019051-gtruu1op 598 1 The the DT cord-019051-gtruu1op 598 2 coronavirus coronavirus NN cord-019051-gtruu1op 598 3 hemagglutinin hemagglutinin NN cord-019051-gtruu1op 598 4 esterase esterase NN cord-019051-gtruu1op 598 5 glycoprotein glycoprotein NN cord-019051-gtruu1op 598 6 Human human JJ cord-019051-gtruu1op 598 7 and and CC cord-019051-gtruu1op 598 8 bovine bovine JJ cord-019051-gtruu1op 598 9 coronaviruses coronaviruse NNS cord-019051-gtruu1op 598 10 recognize recognize VBP cord-019051-gtruu1op 598 11 sialic sialic JJ cord-019051-gtruu1op 598 12 acid acid NN cord-019051-gtruu1op 598 13 - - HYPH cord-019051-gtruu1op 598 14 containing contain VBG cord-019051-gtruu1op 598 15 receptors receptor NNS cord-019051-gtruu1op 598 16 similar similar JJ cord-019051-gtruu1op 598 17 to to IN cord-019051-gtruu1op 598 18 those those DT cord-019051-gtruu1op 598 19 of of IN cord-019051-gtruu1op 598 20 influenza influenza NN cord-019051-gtruu1op 598 21 C c NN cord-019051-gtruu1op 598 22 viruses virus NNS cord-019051-gtruu1op 599 1 The the DT cord-019051-gtruu1op 599 2 coronavirus coronavirus NN cord-019051-gtruu1op 599 3 nucleocapsid nucleocapsid NN cord-019051-gtruu1op 599 4 protein protein NN cord-019051-gtruu1op 599 5 Isolated isolate VBN cord-019051-gtruu1op 600 1 HE he PRP cord-019051-gtruu1op 600 2 protein protein NN cord-019051-gtruu1op 600 3 from from IN cord-019051-gtruu1op 600 4 hemagglutinating hemagglutinate VBG cord-019051-gtruu1op 600 5 encephalomyelitis encephalomyelitis NN cord-019051-gtruu1op 600 6 virus virus NN cord-019051-gtruu1op 600 7 and and CC cord-019051-gtruu1op 600 8 bovine bovine JJ cord-019051-gtruu1op 600 9 coronavirus coronavirus NN cord-019051-gtruu1op 600 10 has have VBZ cord-019051-gtruu1op 600 11 receptor receptor NN cord-019051-gtruu1op 600 12 - - HYPH cord-019051-gtruu1op 600 13 destroying destroy VBG cord-019051-gtruu1op 600 14 and and CC cord-019051-gtruu1op 600 15 receptor receptor NN cord-019051-gtruu1op 600 16 - - HYPH cord-019051-gtruu1op 600 17 binding bind VBG cord-019051-gtruu1op 600 18 activity activity NN cord-019051-gtruu1op 601 1 Feline feline JJ cord-019051-gtruu1op 601 2 aminopeptidase aminopeptidase NN cord-019051-gtruu1op 601 3 N n CD cord-019051-gtruu1op 601 4 serves serve VBZ cord-019051-gtruu1op 601 5 as as IN cord-019051-gtruu1op 601 6 a a DT cord-019051-gtruu1op 601 7 receptor receptor NN cord-019051-gtruu1op 601 8 for for IN cord-019051-gtruu1op 601 9 feline feline JJ cord-019051-gtruu1op 601 10 , , , cord-019051-gtruu1op 601 11 canine canine JJ cord-019051-gtruu1op 601 12 , , , cord-019051-gtruu1op 601 13 porcine porcine JJ cord-019051-gtruu1op 601 14 and and CC cord-019051-gtruu1op 601 15 human human JJ cord-019051-gtruu1op 601 16 coronaviruses coronaviruse NNS cord-019051-gtruu1op 601 17 in in IN cord-019051-gtruu1op 601 18 serogroup serogroup NNP cord-019051-gtruu1op 602 1 1 1 LS cord-019051-gtruu1op 602 2 Angiotensin angiotensin NN cord-019051-gtruu1op 602 3 - - HYPH cord-019051-gtruu1op 602 4 converting convert VBG cord-019051-gtruu1op 602 5 enzyme enzyme NN cord-019051-gtruu1op 602 6 2 2 CD cord-019051-gtruu1op 602 7 is be VBZ cord-019051-gtruu1op 602 8 a a DT cord-019051-gtruu1op 602 9 functional functional JJ cord-019051-gtruu1op 602 10 receptor receptor NN cord-019051-gtruu1op 602 11 for for IN cord-019051-gtruu1op 602 12 the the DT cord-019051-gtruu1op 602 13 SARS SARS NNP cord-019051-gtruu1op 602 14 coronavirus coronavirus NN cord-019051-gtruu1op 603 1 Conformational Conformational NNP cord-019051-gtruu1op 603 2 changes change NNS cord-019051-gtruu1op 603 3 in in IN cord-019051-gtruu1op 603 4 the the DT cord-019051-gtruu1op 603 5 spike spike NN cord-019051-gtruu1op 603 6 glycoprotein glycoprotein NN cord-019051-gtruu1op 603 7 of of IN cord-019051-gtruu1op 603 8 murine murine JJ cord-019051-gtruu1op 603 9 coronavirus coronavirus NN cord-019051-gtruu1op 603 10 are be VBP cord-019051-gtruu1op 603 11 induced induce VBN cord-019051-gtruu1op 603 12 at at IN cord-019051-gtruu1op 603 13 37 37 CD cord-019051-gtruu1op 603 14 degrees degree NNS cord-019051-gtruu1op 603 15 C c NN cord-019051-gtruu1op 603 16 either either CC cord-019051-gtruu1op 603 17 by by IN cord-019051-gtruu1op 603 18 soluble soluble JJ cord-019051-gtruu1op 603 19 murine murine JJ cord-019051-gtruu1op 603 20 CEACAM1 CEACAM1 NNP cord-019051-gtruu1op 603 21 receptors receptor NNS cord-019051-gtruu1op 603 22 or or CC cord-019051-gtruu1op 603 23 by by IN cord-019051-gtruu1op 603 24 pH pH NNP cord-019051-gtruu1op 603 25 8 8 CD cord-019051-gtruu1op 603 26 Coronavirus Coronavirus NNP cord-019051-gtruu1op 603 27 spike spike NN cord-019051-gtruu1op 603 28 proteins protein NNS cord-019051-gtruu1op 603 29 in in IN cord-019051-gtruu1op 603 30 viral viral JJ cord-019051-gtruu1op 603 31 entry entry NN cord-019051-gtruu1op 603 32 and and CC cord-019051-gtruu1op 603 33 pathogenesis pathogenesis NN cord-019051-gtruu1op 604 1 The the DT cord-019051-gtruu1op 604 2 molecular molecular JJ cord-019051-gtruu1op 604 3 biology biology NN cord-019051-gtruu1op 604 4 of of IN cord-019051-gtruu1op 604 5 coronaviruses coronaviruse NNS cord-019051-gtruu1op 604 6 Effects effect NNS cord-019051-gtruu1op 604 7 of of IN cord-019051-gtruu1op 604 8 a a DT cord-019051-gtruu1op 604 9 " " `` cord-019051-gtruu1op 604 10 new new JJ cord-019051-gtruu1op 604 11 " " '' cord-019051-gtruu1op 604 12 human human JJ cord-019051-gtruu1op 604 13 respiratory respiratory JJ cord-019051-gtruu1op 604 14 virus virus NN cord-019051-gtruu1op 604 15 in in IN cord-019051-gtruu1op 604 16 volunteers volunteer NNS cord-019051-gtruu1op 605 1 Coronavirus Coronavirus NNP cord-019051-gtruu1op 605 2 229E 229e CD cord-019051-gtruu1op 605 3 - - HYPH cord-019051-gtruu1op 605 4 related relate VBN cord-019051-gtruu1op 605 5 pneumonia pneumonia NN cord-019051-gtruu1op 605 6 in in IN cord-019051-gtruu1op 605 7 immunocompromised immunocompromised JJ cord-019051-gtruu1op 605 8 patients patient NNS cord-019051-gtruu1op 605 9 Human human JJ cord-019051-gtruu1op 605 10 coronavirus coronavirus NN cord-019051-gtruu1op 605 11 NL NL NNP cord-019051-gtruu1op 605 12 63 63 CD cord-019051-gtruu1op 605 13 , , , cord-019051-gtruu1op 605 14 a a DT cord-019051-gtruu1op 605 15 new new JJ cord-019051-gtruu1op 605 16 respiratory respiratory JJ cord-019051-gtruu1op 605 17 virus virus NN cord-019051-gtruu1op 605 18 Frequent frequent JJ cord-019051-gtruu1op 605 19 detection detection NN cord-019051-gtruu1op 605 20 of of IN cord-019051-gtruu1op 605 21 human human JJ cord-019051-gtruu1op 605 22 coronaviruses coronaviruse NNS cord-019051-gtruu1op 605 23 in in IN cord-019051-gtruu1op 605 24 clinical clinical JJ cord-019051-gtruu1op 605 25 specimens specimen NNS cord-019051-gtruu1op 605 26 from from IN cord-019051-gtruu1op 605 27 patients patient NNS cord-019051-gtruu1op 605 28 with with IN cord-019051-gtruu1op 605 29 respiratory respiratory JJ cord-019051-gtruu1op 605 30 tract tract NN cord-019051-gtruu1op 605 31 infection infection NN cord-019051-gtruu1op 605 32 by by IN cord-019051-gtruu1op 605 33 use use NN cord-019051-gtruu1op 605 34 of of IN cord-019051-gtruu1op 605 35 a a DT cord-019051-gtruu1op 605 36 novel novel JJ cord-019051-gtruu1op 605 37 real real JJ cord-019051-gtruu1op 605 38 - - HYPH cord-019051-gtruu1op 605 39 time time NN cord-019051-gtruu1op 605 40 reverse reverse NN cord-019051-gtruu1op 605 41 - - HYPH cord-019051-gtruu1op 605 42 transcriptase transcriptase NN cord-019051-gtruu1op 605 43 polymerase polymerase NN cord-019051-gtruu1op 605 44 chain chain NN cord-019051-gtruu1op 605 45 reaction reaction NN cord-019051-gtruu1op 605 46 A a DT cord-019051-gtruu1op 605 47 model model NN cord-019051-gtruu1op 605 48 of of IN cord-019051-gtruu1op 605 49 viral viral JJ cord-019051-gtruu1op 605 50 wheeze wheeze NN cord-019051-gtruu1op 605 51 in in IN cord-019051-gtruu1op 605 52 nonasthmatic nonasthmatic JJ cord-019051-gtruu1op 605 53 adults adult NNS cord-019051-gtruu1op 605 54 : : : cord-019051-gtruu1op 606 1 Symptoms symptom NNS cord-019051-gtruu1op 606 2 and and CC cord-019051-gtruu1op 606 3 physiology physiology NN cord-019051-gtruu1op 607 1 A a DT cord-019051-gtruu1op 607 2 previously previously RB cord-019051-gtruu1op 607 3 undescribed undescribed JJ cord-019051-gtruu1op 607 4 coronavirus coronavirus NN cord-019051-gtruu1op 607 5 associated associate VBN cord-019051-gtruu1op 607 6 with with IN cord-019051-gtruu1op 607 7 respiratory respiratory JJ cord-019051-gtruu1op 607 8 disease disease NN cord-019051-gtruu1op 607 9 in in IN cord-019051-gtruu1op 607 10 humans human NNS cord-019051-gtruu1op 607 11 Human human JJ cord-019051-gtruu1op 607 12 coronavirus coronavirus NN cord-019051-gtruu1op 608 1 NL63 nl63 JJ cord-019051-gtruu1op 608 2 infection infection NN cord-019051-gtruu1op 608 3 in in IN cord-019051-gtruu1op 608 4 Canada Canada NNP cord-019051-gtruu1op 608 5 Prospective Prospective NNP cord-019051-gtruu1op 608 6 population population NN cord-019051-gtruu1op 608 7 - - HYPH cord-019051-gtruu1op 608 8 based base VBN cord-019051-gtruu1op 608 9 study study NN cord-019051-gtruu1op 608 10 of of IN cord-019051-gtruu1op 608 11 viral viral JJ cord-019051-gtruu1op 608 12 lower low JJR cord-019051-gtruu1op 608 13 respiratory respiratory JJ cord-019051-gtruu1op 608 14 tract tract NN cord-019051-gtruu1op 608 15 infections infection NNS cord-019051-gtruu1op 608 16 in in IN cord-019051-gtruu1op 608 17 children child NNS cord-019051-gtruu1op 608 18 under under IN cord-019051-gtruu1op 608 19 3 3 CD cord-019051-gtruu1op 608 20 years year NNS cord-019051-gtruu1op 608 21 of of IN cord-019051-gtruu1op 608 22 age age NN cord-019051-gtruu1op 609 1 ( ( -LRB- cord-019051-gtruu1op 609 2 the the DT cord-019051-gtruu1op 609 3 PRI.DE PRI.DE NNP cord-019051-gtruu1op 609 4 study study NN cord-019051-gtruu1op 609 5 ) ) -RRB- cord-019051-gtruu1op 610 1 Prospective prospective JJ cord-019051-gtruu1op 610 2 study study NN cord-019051-gtruu1op 610 3 of of IN cord-019051-gtruu1op 610 4 human human JJ cord-019051-gtruu1op 610 5 metapneumovirus metapneumovirus JJ cord-019051-gtruu1op 610 6 infection infection NN cord-019051-gtruu1op 610 7 in in IN cord-019051-gtruu1op 610 8 children child NNS cord-019051-gtruu1op 610 9 less less JJR cord-019051-gtruu1op 610 10 than than IN cord-019051-gtruu1op 610 11 3 3 CD cord-019051-gtruu1op 610 12 years year NNS cord-019051-gtruu1op 610 13 of of IN cord-019051-gtruu1op 610 14 age age NN cord-019051-gtruu1op 610 15 Clinical clinical JJ cord-019051-gtruu1op 610 16 and and CC cord-019051-gtruu1op 610 17 molecular molecular JJ cord-019051-gtruu1op 610 18 epidemiological epidemiological JJ cord-019051-gtruu1op 610 19 features feature NNS cord-019051-gtruu1op 610 20 of of IN cord-019051-gtruu1op 610 21 coronavirus coronavirus NN cord-019051-gtruu1op 610 22 HKU1-associated hku1-associate VBN cord-019051-gtruu1op 610 23 community community NN cord-019051-gtruu1op 610 24 - - HYPH cord-019051-gtruu1op 610 25 acquired acquire VBN cord-019051-gtruu1op 610 26 pneumonia pneumonia NN cord-019051-gtruu1op 610 27 Evidence evidence NN cord-019051-gtruu1op 610 28 of of IN cord-019051-gtruu1op 610 29 human human JJ cord-019051-gtruu1op 610 30 coronavirus coronavirus NN cord-019051-gtruu1op 610 31 HKU1 HKU1 NNP cord-019051-gtruu1op 610 32 and and CC cord-019051-gtruu1op 610 33 human human JJ cord-019051-gtruu1op 610 34 bocavirus bocavirus NN cord-019051-gtruu1op 610 35 in in IN cord-019051-gtruu1op 610 36 Australian australian JJ cord-019051-gtruu1op 610 37 children child NNS cord-019051-gtruu1op 610 38 Detection Detection NNP cord-019051-gtruu1op 610 39 of of IN cord-019051-gtruu1op 610 40 the the DT cord-019051-gtruu1op 610 41 new new JJ cord-019051-gtruu1op 610 42 human human JJ cord-019051-gtruu1op 610 43 coronavirus coronavirus NN cord-019051-gtruu1op 610 44 HKU1 hku1 CD cord-019051-gtruu1op 610 45 : : : cord-019051-gtruu1op 611 1 A a DT cord-019051-gtruu1op 611 2 report report NN cord-019051-gtruu1op 611 3 of of IN cord-019051-gtruu1op 611 4 6 6 CD cord-019051-gtruu1op 611 5 cases case NNS cord-019051-gtruu1op 611 6 Encyclopedia Encyclopedia NNP cord-019051-gtruu1op 611 7 of of IN cord-019051-gtruu1op 611 8 Virology Virology NNP cord-019051-gtruu1op 611 9 Coronaviruses Coronaviruses NNP cord-019051-gtruu1op 611 10 and and CC cord-019051-gtruu1op 611 11 toroviruses toroviruses NNP cord-019051-gtruu1op 611 12 Coronative Coronative NNP cord-019051-gtruu1op 611 13 antibody antibody NN cord-019051-gtruu1op 611 14 titers titer NNS cord-019051-gtruu1op 611 15 in in IN cord-019051-gtruu1op 611 16 sera sera NNP cord-019051-gtruu1op 611 17 of of IN cord-019051-gtruu1op 611 18 healthy healthy JJ cord-019051-gtruu1op 611 19 adults adult NNS cord-019051-gtruu1op 611 20 and and CC cord-019051-gtruu1op 611 21 experimentally experimentally RB cord-019051-gtruu1op 611 22 infected infect VBN cord-019051-gtruu1op 611 23 volunteers volunteer NNS cord-019051-gtruu1op 611 24 Human human JJ cord-019051-gtruu1op 611 25 coronavirus coronavirus NN cord-019051-gtruu1op 611 26 NL63 NL63 NNP cord-019051-gtruu1op 611 27 employs employ VBZ cord-019051-gtruu1op 611 28 the the DT cord-019051-gtruu1op 611 29 severe severe JJ cord-019051-gtruu1op 611 30 acute acute JJ cord-019051-gtruu1op 611 31 respiratory respiratory JJ cord-019051-gtruu1op 611 32 syndrome syndrome NN cord-019051-gtruu1op 611 33 coronavirus coronavirus NN cord-019051-gtruu1op 611 34 receptor receptor NN cord-019051-gtruu1op 611 35 for for IN cord-019051-gtruu1op 611 36 cellular cellular JJ cord-019051-gtruu1op 611 37 entry entry NN cord-019051-gtruu1op 611 38 Bats bat NNS cord-019051-gtruu1op 611 39 are be VBP cord-019051-gtruu1op 611 40 natural natural JJ cord-019051-gtruu1op 611 41 reservoirs reservoir NNS cord-019051-gtruu1op 611 42 of of IN cord-019051-gtruu1op 611 43 SARS SARS NNP cord-019051-gtruu1op 611 44 - - HYPH cord-019051-gtruu1op 611 45 like like JJ cord-019051-gtruu1op 611 46 coronaviruses coronaviruse NNS cord-019051-gtruu1op 612 1 Severe severe JJ cord-019051-gtruu1op 612 2 acute acute JJ cord-019051-gtruu1op 612 3 respiratory respiratory JJ cord-019051-gtruu1op 612 4 syncytial syncytial JJ cord-019051-gtruu1op 612 5 virus virus NN cord-019051-gtruu1op 612 6 in in IN cord-019051-gtruu1op 612 7 Chinese chinese JJ cord-019051-gtruu1op 612 8 horseshoe horseshoe NN cord-019051-gtruu1op 612 9 bats bat NNS cord-019051-gtruu1op 613 1 Recent recent JJ cord-019051-gtruu1op 613 2 antiviral antiviral JJ cord-019051-gtruu1op 613 3 strategies strategy NNS cord-019051-gtruu1op 613 4 against against IN cord-019051-gtruu1op 613 5 coronavirus coronavirus NN cord-019051-gtruu1op 613 6 - - HYPH cord-019051-gtruu1op 613 7 related relate VBN cord-019051-gtruu1op 613 8 respiratory respiratory JJ cord-019051-gtruu1op 613 9 illnesses illness NNS cord-019051-gtruu1op 613 10 Influenza Influenza NNP cord-019051-gtruu1op 613 11 virus virus NN cord-019051-gtruu1op 613 12 Influenza influenza NN cord-019051-gtruu1op 613 13 seasonality seasonality NN cord-019051-gtruu1op 613 14 : : : cord-019051-gtruu1op 613 15 Underlying underlie VBG cord-019051-gtruu1op 613 16 causes cause NNS cord-019051-gtruu1op 613 17 and and CC cord-019051-gtruu1op 613 18 modeling model VBG cord-019051-gtruu1op 613 19 theories theory NNS cord-019051-gtruu1op 614 1 Orthomyxoviridae Orthomyxoviridae NNP cord-019051-gtruu1op 614 2 : : : cord-019051-gtruu1op 615 1 The the DT cord-019051-gtruu1op 615 2 viruses virus NNS cord-019051-gtruu1op 615 3 and and CC cord-019051-gtruu1op 615 4 their -PRON- PRP$ cord-019051-gtruu1op 615 5 replication replication NN cord-019051-gtruu1op 615 6 Influenza Influenza NNP cord-019051-gtruu1op 615 7 virus virus NN cord-019051-gtruu1op 615 8 : : : cord-019051-gtruu1op 616 1 The the DT cord-019051-gtruu1op 616 2 biology biology NN cord-019051-gtruu1op 616 3 of of IN cord-019051-gtruu1op 616 4 a a DT cord-019051-gtruu1op 616 5 changing change VBG cord-019051-gtruu1op 616 6 virus virus NN cord-019051-gtruu1op 616 7 Caveolae Caveolae NNP cord-019051-gtruu1op 616 8 as as IN cord-019051-gtruu1op 616 9 an an DT cord-019051-gtruu1op 616 10 additional additional JJ cord-019051-gtruu1op 616 11 route route NN cord-019051-gtruu1op 616 12 for for IN cord-019051-gtruu1op 616 13 influenza influenza NN cord-019051-gtruu1op 616 14 virus virus NN cord-019051-gtruu1op 616 15 endocytosis endocytosis NN cord-019051-gtruu1op 616 16 in in IN cord-019051-gtruu1op 616 17 MDCK MDCK NNP cord-019051-gtruu1op 616 18 cells cell NNS cord-019051-gtruu1op 617 1 Influenza Influenza NNP cord-019051-gtruu1op 617 2 A a DT cord-019051-gtruu1op 617 3 virusM2 virusm2 JJ cord-019051-gtruu1op 617 4 ion ion NN cord-019051-gtruu1op 617 5 channel channel NN cord-019051-gtruu1op 617 6 activity activity NN cord-019051-gtruu1op 617 7 is be VBZ cord-019051-gtruu1op 617 8 essential essential JJ cord-019051-gtruu1op 617 9 for for IN cord-019051-gtruu1op 617 10 efficient efficient JJ cord-019051-gtruu1op 617 11 replication replication NN cord-019051-gtruu1op 617 12 in in IN cord-019051-gtruu1op 617 13 tissue tissue NN cord-019051-gtruu1op 617 14 culture culture NN cord-019051-gtruu1op 618 1 Sialic sialic NN cord-019051-gtruu1op 618 2 acid acid NN cord-019051-gtruu1op 618 3 species specie NNS cord-019051-gtruu1op 618 4 as as IN cord-019051-gtruu1op 618 5 a a DT cord-019051-gtruu1op 618 6 determinant determinant NN cord-019051-gtruu1op 618 7 of of IN cord-019051-gtruu1op 618 8 the the DT cord-019051-gtruu1op 618 9 host host NN cord-019051-gtruu1op 618 10 range range NN cord-019051-gtruu1op 618 11 of of IN cord-019051-gtruu1op 618 12 influenza influenza NN cord-019051-gtruu1op 618 13 A a DT cord-019051-gtruu1op 618 14 viruses virus NNS cord-019051-gtruu1op 619 1 Does do VBZ cord-019051-gtruu1op 619 2 this this DT cord-019051-gtruu1op 619 3 patient patient NN cord-019051-gtruu1op 619 4 have have VB cord-019051-gtruu1op 619 5 influenza influenza NN cord-019051-gtruu1op 619 6 Influenza Influenza NNP cord-019051-gtruu1op 619 7 virus virus NN cord-019051-gtruu1op 619 8 and and CC cord-019051-gtruu1op 619 9 CNS CNS NNP cord-019051-gtruu1op 619 10 manifestations manifestation NNS cord-019051-gtruu1op 619 11 Influenza influenza NN cord-019051-gtruu1op 619 12 - - HYPH cord-019051-gtruu1op 619 13 associated associate VBN cord-019051-gtruu1op 619 14 deaths death NNS cord-019051-gtruu1op 619 15 among among IN cord-019051-gtruu1op 619 16 children child NNS cord-019051-gtruu1op 619 17 in in IN cord-019051-gtruu1op 619 18 the the DT cord-019051-gtruu1op 619 19 United United NNP cord-019051-gtruu1op 619 20 States States NNP cord-019051-gtruu1op 619 21 Influenza Influenza NNP cord-019051-gtruu1op 619 22 B B NNP cord-019051-gtruu1op 619 23 virus virus NN cord-019051-gtruu1op 619 24 infection infection NN cord-019051-gtruu1op 619 25 associated associate VBN cord-019051-gtruu1op 619 26 with with IN cord-019051-gtruu1op 619 27 non non JJ cord-019051-gtruu1op 619 28 - - JJ cord-019051-gtruu1op 619 29 bacterial bacterial JJ cord-019051-gtruu1op 619 30 septic septic JJ cord-019051-gtruu1op 619 31 shock shock NN cord-019051-gtruu1op 619 32 - - HYPH cord-019051-gtruu1op 619 33 like like JJ cord-019051-gtruu1op 619 34 illness illness NN cord-019051-gtruu1op 619 35 Histopathologic Histopathologic NNP cord-019051-gtruu1op 619 36 and and CC cord-019051-gtruu1op 619 37 immunohistochemical immunohistochemical JJ cord-019051-gtruu1op 619 38 features feature NNS cord-019051-gtruu1op 619 39 of of IN cord-019051-gtruu1op 619 40 fatal fatal JJ cord-019051-gtruu1op 619 41 influenza influenza NN cord-019051-gtruu1op 619 42 virus virus NN cord-019051-gtruu1op 619 43 infection infection NN cord-019051-gtruu1op 619 44 in in IN cord-019051-gtruu1op 619 45 children child NNS cord-019051-gtruu1op 619 46 during during IN cord-019051-gtruu1op 619 47 the the DT cord-019051-gtruu1op 619 48 2003 2003 CD cord-019051-gtruu1op 619 49 - - SYM cord-019051-gtruu1op 619 50 2004 2004 CD cord-019051-gtruu1op 619 51 season season NN cord-019051-gtruu1op 619 52 Influenza Influenza NNP cord-019051-gtruu1op 619 53 B B NNP cord-019051-gtruu1op 619 54 virus virus NN cord-019051-gtruu1op 619 55 in in IN cord-019051-gtruu1op 619 56 seals seal NNS cord-019051-gtruu1op 619 57 Differential differential JJ cord-019051-gtruu1op 619 58 sensitivity sensitivity NN cord-019051-gtruu1op 619 59 of of IN cord-019051-gtruu1op 619 60 human human NN cord-019051-gtruu1op 619 61 , , , cord-019051-gtruu1op 619 62 avian avian JJ cord-019051-gtruu1op 619 63 , , , cord-019051-gtruu1op 619 64 and and CC cord-019051-gtruu1op 619 65 equine equine NN cord-019051-gtruu1op 620 1 influenza influenza NN cord-019051-gtruu1op 620 2 A a DT cord-019051-gtruu1op 620 3 viruses virus NNS cord-019051-gtruu1op 620 4 to to IN cord-019051-gtruu1op 620 5 a a DT cord-019051-gtruu1op 620 6 glycoprotein glycoprotein NN cord-019051-gtruu1op 620 7 inhibitor inhibitor NN cord-019051-gtruu1op 620 8 of of IN cord-019051-gtruu1op 620 9 infection infection NN cord-019051-gtruu1op 620 10 : : : cord-019051-gtruu1op 620 11 Selection selection NN cord-019051-gtruu1op 620 12 of of IN cord-019051-gtruu1op 620 13 receptor receptor NN cord-019051-gtruu1op 620 14 specific specific JJ cord-019051-gtruu1op 620 15 variants variant NNS cord-019051-gtruu1op 621 1 Receptor receptor NN cord-019051-gtruu1op 621 2 determinants determinant NNS cord-019051-gtruu1op 621 3 of of IN cord-019051-gtruu1op 621 4 human human JJ cord-019051-gtruu1op 621 5 and and CC cord-019051-gtruu1op 621 6 animal animal NN cord-019051-gtruu1op 621 7 influenza influenza NN cord-019051-gtruu1op 621 8 virus virus NN cord-019051-gtruu1op 621 9 isolates isolate VBZ cord-019051-gtruu1op 621 10 : : : cord-019051-gtruu1op 622 1 Differences difference NNS cord-019051-gtruu1op 622 2 in in IN cord-019051-gtruu1op 622 3 receptor receptor NN cord-019051-gtruu1op 622 4 specificity specificity NN cord-019051-gtruu1op 622 5 of of IN cord-019051-gtruu1op 622 6 the the DT cord-019051-gtruu1op 622 7 H3 H3 NNP cord-019051-gtruu1op 622 8 hemagglutinin hemagglutinin NN cord-019051-gtruu1op 622 9 based base VBN cord-019051-gtruu1op 622 10 on on IN cord-019051-gtruu1op 622 11 species specie NNS cord-019051-gtruu1op 622 12 of of IN cord-019051-gtruu1op 622 13 origin origin NN cord-019051-gtruu1op 622 14 Positive positive JJ cord-019051-gtruu1op 622 15 Darwinian darwinian JJ cord-019051-gtruu1op 622 16 evolution evolution NN cord-019051-gtruu1op 622 17 in in IN cord-019051-gtruu1op 622 18 human human JJ cord-019051-gtruu1op 622 19 influenza influenza NN cord-019051-gtruu1op 622 20 A a DT cord-019051-gtruu1op 622 21 viruses virus NNS cord-019051-gtruu1op 623 1 The the DT cord-019051-gtruu1op 623 2 epidemiology epidemiology NN cord-019051-gtruu1op 623 3 of of IN cord-019051-gtruu1op 623 4 influenza influenza NN cord-019051-gtruu1op 623 5 and and CC cord-019051-gtruu1op 623 6 its -PRON- PRP$ cord-019051-gtruu1op 623 7 control control NN cord-019051-gtruu1op 623 8 Influenza Influenza NNP cord-019051-gtruu1op 623 9 and and CC cord-019051-gtruu1op 623 10 influenza influenza NN cord-019051-gtruu1op 623 11 vaccination vaccination NN cord-019051-gtruu1op 623 12 Waiting wait VBG cord-019051-gtruu1op 623 13 for for IN cord-019051-gtruu1op 623 14 a a DT cord-019051-gtruu1op 623 15 pandemic pandemic NN