id sid tid token lemma pos cord-018907-c84t1bo5 1 1 key key JJ cord-018907-c84t1bo5 1 2 : : : cord-018907-c84t1bo5 1 3 cord-018907-c84t1bo5 cord-018907-c84t1bo5 NN cord-018907-c84t1bo5 1 4 authors author NNS cord-018907-c84t1bo5 1 5 : : : cord-018907-c84t1bo5 1 6 Bin Bin NNP cord-018907-c84t1bo5 1 7 - - HYPH cord-018907-c84t1bo5 1 8 Hussain Hussain NNP cord-018907-c84t1bo5 1 9 , , , cord-018907-c84t1bo5 1 10 Ibrahim Ibrahim NNP cord-018907-c84t1bo5 1 11 title title NN cord-018907-c84t1bo5 1 12 : : : cord-018907-c84t1bo5 1 13 Infections infection NNS cord-018907-c84t1bo5 1 14 in in IN cord-018907-c84t1bo5 1 15 the the DT cord-018907-c84t1bo5 1 16 Immunocompromised Immunocompromised NNP cord-018907-c84t1bo5 1 17 Host Host NNP cord-018907-c84t1bo5 1 18 date date NN cord-018907-c84t1bo5 1 19 : : : cord-018907-c84t1bo5 1 20 2012 2012 CD cord-018907-c84t1bo5 1 21 journal journal NNP cord-018907-c84t1bo5 1 22 : : : cord-018907-c84t1bo5 2 1 Textbook textbook NN cord-018907-c84t1bo5 2 2 of of IN cord-018907-c84t1bo5 2 3 Clinical Clinical NNP cord-018907-c84t1bo5 2 4 Pediatrics Pediatrics NNP cord-018907-c84t1bo5 2 5 DOI DOI NNP cord-018907-c84t1bo5 2 6 : : : cord-018907-c84t1bo5 3 1 10.1007/978 10.1007/978 LS cord-018907-c84t1bo5 3 2 - - SYM cord-018907-c84t1bo5 3 3 3 3 CD cord-018907-c84t1bo5 3 4 - - HYPH cord-018907-c84t1bo5 3 5 642 642 CD cord-018907-c84t1bo5 3 6 - - HYPH cord-018907-c84t1bo5 3 7 02202 02202 CD cord-018907-c84t1bo5 3 8 - - HYPH cord-018907-c84t1bo5 3 9 9_68 9_68 CD cord-018907-c84t1bo5 3 10 sha sha NNP cord-018907-c84t1bo5 3 11 : : : cord-018907-c84t1bo5 3 12 d862b4875d483afd2789ea3f5df303c3bdbd76d4 d862b4875d483afd2789ea3f5df303c3bdbd76d4 NNP cord-018907-c84t1bo5 3 13 doc_id doc_id NNPS cord-018907-c84t1bo5 3 14 : : : cord-018907-c84t1bo5 3 15 18907 18907 CD cord-018907-c84t1bo5 3 16 cord_uid cord_uid NNS cord-018907-c84t1bo5 3 17 : : : cord-018907-c84t1bo5 4 1 c84t1bo5 c84t1bo5 NNP cord-018907-c84t1bo5 4 2 nan nan NNP cord-018907-c84t1bo5 4 3 Infections Infections NNP cord-018907-c84t1bo5 4 4 are be VBP cord-018907-c84t1bo5 4 5 considered consider VBN cord-018907-c84t1bo5 4 6 a a DT cord-018907-c84t1bo5 4 7 major major JJ cord-018907-c84t1bo5 4 8 cause cause NN cord-018907-c84t1bo5 4 9 of of IN cord-018907-c84t1bo5 4 10 morbidity morbidity NN cord-018907-c84t1bo5 4 11 and and CC cord-018907-c84t1bo5 4 12 mortality mortality NN cord-018907-c84t1bo5 4 13 in in IN cord-018907-c84t1bo5 4 14 immunocompromised immunocompromised JJ cord-018907-c84t1bo5 4 15 children child NNS cord-018907-c84t1bo5 4 16 . . . cord-018907-c84t1bo5 5 1 The the DT cord-018907-c84t1bo5 5 2 survival survival NN cord-018907-c84t1bo5 5 3 rate rate NN cord-018907-c84t1bo5 5 4 in in IN cord-018907-c84t1bo5 5 5 this this DT cord-018907-c84t1bo5 5 6 particular particular JJ cord-018907-c84t1bo5 5 7 population population NN cord-018907-c84t1bo5 5 8 has have VBZ cord-018907-c84t1bo5 5 9 increased increase VBN cord-018907-c84t1bo5 5 10 over over IN cord-018907-c84t1bo5 5 11 the the DT cord-018907-c84t1bo5 5 12 last last JJ cord-018907-c84t1bo5 5 13 3 3 CD cord-018907-c84t1bo5 5 14 decades decade NNS cord-018907-c84t1bo5 5 15 . . . cord-018907-c84t1bo5 6 1 This this DT cord-018907-c84t1bo5 6 2 is be VBZ cord-018907-c84t1bo5 6 3 mainly mainly RB cord-018907-c84t1bo5 6 4 due due JJ cord-018907-c84t1bo5 6 5 to to IN cord-018907-c84t1bo5 6 6 the the DT cord-018907-c84t1bo5 6 7 advancement advancement NN cord-018907-c84t1bo5 6 8 in in IN cord-018907-c84t1bo5 6 9 medical medical JJ cord-018907-c84t1bo5 6 10 technology technology NN cord-018907-c84t1bo5 6 11 leading lead VBG cord-018907-c84t1bo5 6 12 to to IN cord-018907-c84t1bo5 6 13 improvement improvement NN cord-018907-c84t1bo5 6 14 in in IN cord-018907-c84t1bo5 6 15 diagnosis diagnosis NN cord-018907-c84t1bo5 6 16 capabilities capability NNS cord-018907-c84t1bo5 6 17 as as RB cord-018907-c84t1bo5 6 18 well well RB cord-018907-c84t1bo5 6 19 as as IN cord-018907-c84t1bo5 6 20 supportive supportive JJ cord-018907-c84t1bo5 6 21 care care NN cord-018907-c84t1bo5 6 22 including include VBG cord-018907-c84t1bo5 6 23 antimicrobial antimicrobial JJ cord-018907-c84t1bo5 6 24 therapy therapy NN cord-018907-c84t1bo5 6 25 . . . cord-018907-c84t1bo5 7 1 Immunodeficiency immunodeficiency NN cord-018907-c84t1bo5 7 2 can can MD cord-018907-c84t1bo5 7 3 be be VB cord-018907-c84t1bo5 7 4 divided divide VBN cord-018907-c84t1bo5 7 5 into into IN cord-018907-c84t1bo5 7 6 primary primary JJ cord-018907-c84t1bo5 7 7 and and CC cord-018907-c84t1bo5 7 8 secondary secondary JJ cord-018907-c84t1bo5 7 9 immunodeficiency immunodeficiency NN cord-018907-c84t1bo5 7 10 disorders disorder NNS cord-018907-c84t1bo5 7 11 . . . cord-018907-c84t1bo5 8 1 Primary primary JJ cord-018907-c84t1bo5 8 2 immunodeficiency immunodeficiency NN cord-018907-c84t1bo5 8 3 disorders disorder NNS cord-018907-c84t1bo5 8 4 including include VBG cord-018907-c84t1bo5 8 5 combined combine VBN cord-018907-c84t1bo5 8 6 T t NN cord-018907-c84t1bo5 8 7 - - HYPH cord-018907-c84t1bo5 8 8 cell cell NN cord-018907-c84t1bo5 8 9 and and CC cord-018907-c84t1bo5 8 10 B b NN cord-018907-c84t1bo5 8 11 - - HYPH cord-018907-c84t1bo5 8 12 cell cell NN cord-018907-c84t1bo5 8 13 immunodeficiencies immunodeficiency NNS cord-018907-c84t1bo5 8 14 , , , cord-018907-c84t1bo5 8 15 antibody antibody NN cord-018907-c84t1bo5 8 16 deficiency deficiency NN cord-018907-c84t1bo5 8 17 , , , cord-018907-c84t1bo5 8 18 disease disease NN cord-018907-c84t1bo5 8 19 of of IN cord-018907-c84t1bo5 8 20 immune immune JJ cord-018907-c84t1bo5 8 21 dysregulation dysregulation NN cord-018907-c84t1bo5 8 22 , , , cord-018907-c84t1bo5 8 23 congenital congenital JJ cord-018907-c84t1bo5 8 24 defects defect NNS cord-018907-c84t1bo5 8 25 of of IN cord-018907-c84t1bo5 8 26 Phagocyte Phagocyte NNP cord-018907-c84t1bo5 8 27 number number NN cord-018907-c84t1bo5 8 28 or or CC cord-018907-c84t1bo5 8 29 function function NN cord-018907-c84t1bo5 8 30 or or CC cord-018907-c84t1bo5 8 31 both both DT cord-018907-c84t1bo5 8 32 , , , cord-018907-c84t1bo5 8 33 defects defect NNS cord-018907-c84t1bo5 8 34 in in IN cord-018907-c84t1bo5 8 35 innate innate JJ cord-018907-c84t1bo5 8 36 immunity immunity NN cord-018907-c84t1bo5 8 37 , , , cord-018907-c84t1bo5 8 38 autoimmunity autoimmunity NN cord-018907-c84t1bo5 8 39 disorders disorder NNS cord-018907-c84t1bo5 8 40 , , , cord-018907-c84t1bo5 8 41 complement complement NN cord-018907-c84t1bo5 8 42 deficiencies deficiency NNS cord-018907-c84t1bo5 8 43 , , , cord-018907-c84t1bo5 8 44 and and CC cord-018907-c84t1bo5 8 45 cytokine cytokine NN cord-018907-c84t1bo5 8 46 defects defect NNS cord-018907-c84t1bo5 8 47 . . . cord-018907-c84t1bo5 9 1 Secondary secondary JJ cord-018907-c84t1bo5 9 2 immunodeficiency immunodeficiency NN cord-018907-c84t1bo5 9 3 disorders disorder NNS cord-018907-c84t1bo5 9 4 include include VBP cord-018907-c84t1bo5 9 5 human human JJ cord-018907-c84t1bo5 9 6 immunodeficiency immunodeficiency NN cord-018907-c84t1bo5 9 7 virus virus NN cord-018907-c84t1bo5 9 8 ( ( -LRB- cord-018907-c84t1bo5 9 9 HIV HIV NNP cord-018907-c84t1bo5 9 10 ) ) -RRB- cord-018907-c84t1bo5 9 11 and and CC cord-018907-c84t1bo5 9 12 acquired acquire VBD cord-018907-c84t1bo5 9 13 immune immune JJ cord-018907-c84t1bo5 9 14 deficiency deficiency NN cord-018907-c84t1bo5 9 15 syndrome syndrome NN cord-018907-c84t1bo5 9 16 ( ( -LRB- cord-018907-c84t1bo5 9 17 AIDS AIDS NNP cord-018907-c84t1bo5 9 18 ) ) -RRB- cord-018907-c84t1bo5 9 19 -both -both . cord-018907-c84t1bo5 10 1 of of IN cord-018907-c84t1bo5 10 2 which which WDT cord-018907-c84t1bo5 10 3 lead lead NN cord-018907-c84t1bo5 10 4 to to IN cord-018907-c84t1bo5 10 5 altered alter VBN cord-018907-c84t1bo5 10 6 cellular cellular JJ cord-018907-c84t1bo5 10 7 immunity immunity NN cord-018907-c84t1bo5 10 8 -dysgammaglobulinemia -dysgammaglobulinemia NN cord-018907-c84t1bo5 10 9 , , , cord-018907-c84t1bo5 10 10 defective defective JJ cord-018907-c84t1bo5 10 11 phagocytic phagocytic JJ cord-018907-c84t1bo5 10 12 function function NN cord-018907-c84t1bo5 10 13 or or CC cord-018907-c84t1bo5 10 14 neutropenia neutropenia NN cord-018907-c84t1bo5 10 15 . . . cord-018907-c84t1bo5 11 1 Cancer cancer NN cord-018907-c84t1bo5 11 2 leading lead VBG cord-018907-c84t1bo5 11 3 to to IN cord-018907-c84t1bo5 11 4 neutropenia neutropenia NN cord-018907-c84t1bo5 11 5 , , , cord-018907-c84t1bo5 11 6 lymphopenia lymphopenia NNP cord-018907-c84t1bo5 11 7 , , , cord-018907-c84t1bo5 11 8 humoral humoral JJ cord-018907-c84t1bo5 11 9 deficiencies deficiency NNS cord-018907-c84t1bo5 11 10 and and CC cord-018907-c84t1bo5 11 11 altered alter VBN cord-018907-c84t1bo5 11 12 physical physical JJ cord-018907-c84t1bo5 11 13 integrity integrity NN cord-018907-c84t1bo5 11 14 especially especially RB cord-018907-c84t1bo5 11 15 with with IN cord-018907-c84t1bo5 11 16 the the DT cord-018907-c84t1bo5 11 17 use use NN cord-018907-c84t1bo5 11 18 of of IN cord-018907-c84t1bo5 11 19 chemotherapeutic chemotherapeutic JJ cord-018907-c84t1bo5 11 20 agents agent NNS cord-018907-c84t1bo5 11 21 leading lead VBG cord-018907-c84t1bo5 11 22 to to IN cord-018907-c84t1bo5 11 23 disruption disruption NN cord-018907-c84t1bo5 11 24 barrier barrier NN cord-018907-c84t1bo5 11 25 integrity integrity NN cord-018907-c84t1bo5 11 26 with with IN cord-018907-c84t1bo5 11 27 mucositis mucositis NNP cord-018907-c84t1bo5 11 28 leading lead VBG cord-018907-c84t1bo5 11 29 to to IN cord-018907-c84t1bo5 11 30 easy easy JJ cord-018907-c84t1bo5 11 31 access access NN cord-018907-c84t1bo5 11 32 of of IN cord-018907-c84t1bo5 11 33 microorganisms microorganism NNS cord-018907-c84t1bo5 11 34 , , , cord-018907-c84t1bo5 11 35 solid solid JJ cord-018907-c84t1bo5 11 36 organ organ NN cord-018907-c84t1bo5 11 37 transplant transplant NN cord-018907-c84t1bo5 11 38 leading lead VBG cord-018907-c84t1bo5 11 39 to to IN cord-018907-c84t1bo5 11 40 deficiencies deficiency NNS cord-018907-c84t1bo5 11 41 in in IN cord-018907-c84t1bo5 11 42 cellular cellular JJ cord-018907-c84t1bo5 11 43 and and CC cord-018907-c84t1bo5 11 44 phagocytic phagocytic JJ cord-018907-c84t1bo5 11 45 immunity immunity NN cord-018907-c84t1bo5 11 46 , , , cord-018907-c84t1bo5 11 47 malnutrition malnutrition NN cord-018907-c84t1bo5 11 48 which which WDT cord-018907-c84t1bo5 11 49 leads lead VBZ cord-018907-c84t1bo5 11 50 to to IN cord-018907-c84t1bo5 11 51 impaired impaired JJ cord-018907-c84t1bo5 11 52 immunity immunity NN cord-018907-c84t1bo5 11 53 , , , cord-018907-c84t1bo5 11 54 and and CC cord-018907-c84t1bo5 11 55 complement complement JJ cord-018907-c84t1bo5 11 56 activity activity NN cord-018907-c84t1bo5 11 57 . . . cord-018907-c84t1bo5 12 1 Fever fever NN cord-018907-c84t1bo5 12 2 is be VBZ cord-018907-c84t1bo5 12 3 the the DT cord-018907-c84t1bo5 12 4 main main JJ cord-018907-c84t1bo5 12 5 manifestation manifestation NN cord-018907-c84t1bo5 12 6 and and CC cord-018907-c84t1bo5 12 7 occasionally occasionally RB cord-018907-c84t1bo5 12 8 the the DT cord-018907-c84t1bo5 12 9 only only JJ cord-018907-c84t1bo5 12 10 sign sign NN cord-018907-c84t1bo5 12 11 of of IN cord-018907-c84t1bo5 12 12 infection infection NN cord-018907-c84t1bo5 12 13 in in IN cord-018907-c84t1bo5 12 14 immunocompromised immunocompromised JJ cord-018907-c84t1bo5 12 15 children child NNS cord-018907-c84t1bo5 12 16 . . . cord-018907-c84t1bo5 13 1 When when WRB cord-018907-c84t1bo5 13 2 approaching approach VBG cord-018907-c84t1bo5 13 3 a a DT cord-018907-c84t1bo5 13 4 patient patient NN cord-018907-c84t1bo5 13 5 with with IN cord-018907-c84t1bo5 13 6 immunodeficiency immunodeficiency NN cord-018907-c84t1bo5 13 7 in in IN cord-018907-c84t1bo5 13 8 the the DT cord-018907-c84t1bo5 13 9 context context NN cord-018907-c84t1bo5 13 10 of of IN cord-018907-c84t1bo5 13 11 infection infection NN cord-018907-c84t1bo5 13 12 , , , cord-018907-c84t1bo5 13 13 one one PRP cord-018907-c84t1bo5 13 14 needs need VBZ cord-018907-c84t1bo5 13 15 to to TO cord-018907-c84t1bo5 13 16 look look VB cord-018907-c84t1bo5 13 17 at at IN cord-018907-c84t1bo5 13 18 the the DT cord-018907-c84t1bo5 13 19 net net JJ cord-018907-c84t1bo5 13 20 state state NN cord-018907-c84t1bo5 13 21 of of IN cord-018907-c84t1bo5 13 22 immunosuppression immunosuppression NN cord-018907-c84t1bo5 13 23 . . . cord-018907-c84t1bo5 14 1 The the DT cord-018907-c84t1bo5 14 2 net net JJ cord-018907-c84t1bo5 14 3 state state NN cord-018907-c84t1bo5 14 4 of of IN cord-018907-c84t1bo5 14 5 immunosuppression immunosuppression NN cord-018907-c84t1bo5 14 6 can can MD cord-018907-c84t1bo5 14 7 be be VB cord-018907-c84t1bo5 14 8 evaluated evaluate VBN cord-018907-c84t1bo5 14 9 by by IN cord-018907-c84t1bo5 14 10 the the DT cord-018907-c84t1bo5 14 11 host host NN cord-018907-c84t1bo5 14 12 defense defense NN cord-018907-c84t1bo5 14 13 defects defect NNS cord-018907-c84t1bo5 14 14 caused cause VBN cord-018907-c84t1bo5 14 15 by by IN cord-018907-c84t1bo5 14 16 the the DT cord-018907-c84t1bo5 14 17 primary primary JJ cord-018907-c84t1bo5 14 18 disease disease NN cord-018907-c84t1bo5 14 19 , , , cord-018907-c84t1bo5 14 20 dose dose NN cord-018907-c84t1bo5 14 21 and and CC cord-018907-c84t1bo5 14 22 duration duration NN cord-018907-c84t1bo5 14 23 of of IN cord-018907-c84t1bo5 14 24 the the DT cord-018907-c84t1bo5 14 25 immunosuppressive immunosuppressive JJ cord-018907-c84t1bo5 14 26 therapy therapy NN cord-018907-c84t1bo5 14 27 ( ( -LRB- cord-018907-c84t1bo5 14 28 the the DT cord-018907-c84t1bo5 14 29 longer long JJR cord-018907-c84t1bo5 14 30 duration duration NN cord-018907-c84t1bo5 14 31 of of IN cord-018907-c84t1bo5 14 32 immunosuppressive immunosuppressive JJ cord-018907-c84t1bo5 14 33 therapy therapy NN cord-018907-c84t1bo5 14 34 , , , cord-018907-c84t1bo5 14 35 the the DT cord-018907-c84t1bo5 14 36 higher high JJR cord-018907-c84t1bo5 14 37 risk risk NN cord-018907-c84t1bo5 14 38 of of IN cord-018907-c84t1bo5 14 39 infection infection NN cord-018907-c84t1bo5 14 40 ) ) -RRB- cord-018907-c84t1bo5 14 41 , , , cord-018907-c84t1bo5 14 42 presence presence NN cord-018907-c84t1bo5 14 43 of of IN cord-018907-c84t1bo5 14 44 neutropenia neutropenia NN cord-018907-c84t1bo5 14 45 , , , cord-018907-c84t1bo5 14 46 and and CC cord-018907-c84t1bo5 14 47 anatomical anatomical JJ cord-018907-c84t1bo5 14 48 and and CC cord-018907-c84t1bo5 14 49 functional functional JJ cord-018907-c84t1bo5 14 50 integrity integrity NN cord-018907-c84t1bo5 14 51 because because IN cord-018907-c84t1bo5 14 52 defect defect NN cord-018907-c84t1bo5 14 53 in in IN cord-018907-c84t1bo5 14 54 the the DT cord-018907-c84t1bo5 14 55 skin skin NN cord-018907-c84t1bo5 14 56 or or CC cord-018907-c84t1bo5 14 57 mucosa mucosa NN cord-018907-c84t1bo5 14 58 can can MD cord-018907-c84t1bo5 14 59 lead lead VB cord-018907-c84t1bo5 14 60 to to IN cord-018907-c84t1bo5 14 61 easy easy JJ cord-018907-c84t1bo5 14 62 access access NN cord-018907-c84t1bo5 14 63 for for IN cord-018907-c84t1bo5 14 64 the the DT cord-018907-c84t1bo5 14 65 microorganisms microorganism NNS cord-018907-c84t1bo5 14 66 , , , cord-018907-c84t1bo5 14 67 metabolic metabolic JJ cord-018907-c84t1bo5 14 68 factors factor NNS cord-018907-c84t1bo5 14 69 , , , cord-018907-c84t1bo5 14 70 and and CC cord-018907-c84t1bo5 14 71 infection infection NN cord-018907-c84t1bo5 14 72 with with IN cord-018907-c84t1bo5 14 73 immunomodulating immunomodulate VBG cord-018907-c84t1bo5 14 74 viruses virus NNS cord-018907-c84t1bo5 14 75 ( ( -LRB- cord-018907-c84t1bo5 14 76 HIV HIV NNP cord-018907-c84t1bo5 14 77 , , , cord-018907-c84t1bo5 14 78 HBV HBV NNP cord-018907-c84t1bo5 14 79 , , , cord-018907-c84t1bo5 14 80 HCV HCV NNP cord-018907-c84t1bo5 14 81 , , , cord-018907-c84t1bo5 14 82 CMV CMV NNP cord-018907-c84t1bo5 14 83 , , , cord-018907-c84t1bo5 14 84 EBV EBV NNP cord-018907-c84t1bo5 14 85 , , , cord-018907-c84t1bo5 14 86 and and CC cord-018907-c84t1bo5 14 87 HHV-6 HHV-6 NNP cord-018907-c84t1bo5 14 88 ) ) -RRB- cord-018907-c84t1bo5 14 89 . . . cord-018907-c84t1bo5 15 1 Risk risk NN cord-018907-c84t1bo5 15 2 of of IN cord-018907-c84t1bo5 15 3 infections infection NNS cord-018907-c84t1bo5 15 4 can can MD cord-018907-c84t1bo5 15 5 be be VB cord-018907-c84t1bo5 15 6 classified classify VBN cord-018907-c84t1bo5 15 7 as as IN cord-018907-c84t1bo5 15 8 high high JJ cord-018907-c84t1bo5 15 9 , , , cord-018907-c84t1bo5 15 10 intermediate intermediate JJ cord-018907-c84t1bo5 15 11 , , , cord-018907-c84t1bo5 15 12 and and CC cord-018907-c84t1bo5 15 13 low low JJ cord-018907-c84t1bo5 15 14 . . . cord-018907-c84t1bo5 16 1 High high JJ cord-018907-c84t1bo5 16 2 risk risk NN cord-018907-c84t1bo5 16 3 includes include VBZ cord-018907-c84t1bo5 16 4 hematologic hematologic JJ cord-018907-c84t1bo5 16 5 malignancies malignancy NNS cord-018907-c84t1bo5 16 6 , , , cord-018907-c84t1bo5 16 7 AIDS AIDS NNP cord-018907-c84t1bo5 16 8 , , , cord-018907-c84t1bo5 16 9 HSCT HSCT NNP cord-018907-c84t1bo5 16 10 , , , cord-018907-c84t1bo5 16 11 splenectomized splenectomized JJ cord-018907-c84t1bo5 16 12 patient patient NN cord-018907-c84t1bo5 16 13 , , , cord-018907-c84t1bo5 16 14 and and CC cord-018907-c84t1bo5 16 15 congenital congenital JJ cord-018907-c84t1bo5 16 16 immunodeficiency immunodeficiency NN cord-018907-c84t1bo5 16 17 especially especially RB cord-018907-c84t1bo5 16 18 severe severe JJ cord-018907-c84t1bo5 16 19 combined combine VBN cord-018907-c84t1bo5 16 20 immune immune JJ cord-018907-c84t1bo5 16 21 deficiency deficiency NN cord-018907-c84t1bo5 16 22 ( ( -LRB- cord-018907-c84t1bo5 16 23 SCID SCID NNP cord-018907-c84t1bo5 16 24 ) ) -RRB- cord-018907-c84t1bo5 16 25 . . . cord-018907-c84t1bo5 17 1 Intermediate intermediate JJ cord-018907-c84t1bo5 17 2 risk risk NN cord-018907-c84t1bo5 17 3 includes include VBZ cord-018907-c84t1bo5 17 4 solid solid JJ cord-018907-c84t1bo5 17 5 tumors tumor NNS cord-018907-c84t1bo5 17 6 , , , cord-018907-c84t1bo5 17 7 HIV HIV NNP cord-018907-c84t1bo5 17 8 / / SYM cord-018907-c84t1bo5 17 9 AIDS AIDS NNP cord-018907-c84t1bo5 17 10 , , , cord-018907-c84t1bo5 17 11 and and CC cord-018907-c84t1bo5 17 12 solid solid JJ cord-018907-c84t1bo5 17 13 organ organ NN cord-018907-c84t1bo5 17 14 transplantation transplantation NN cord-018907-c84t1bo5 17 15 . . . cord-018907-c84t1bo5 18 1 Low low JJ cord-018907-c84t1bo5 18 2 - - HYPH cord-018907-c84t1bo5 18 3 risk risk NN cord-018907-c84t1bo5 18 4 patients patient NNS cord-018907-c84t1bo5 18 5 include include VBP cord-018907-c84t1bo5 18 6 patients patient NNS cord-018907-c84t1bo5 18 7 with with IN cord-018907-c84t1bo5 18 8 corticosteroid corticosteroid NN cord-018907-c84t1bo5 18 9 therapy therapy NN cord-018907-c84t1bo5 18 10 , , , cord-018907-c84t1bo5 18 11 local local JJ cord-018907-c84t1bo5 18 12 defects defect NNS cord-018907-c84t1bo5 18 13 , , , cord-018907-c84t1bo5 18 14 and and CC cord-018907-c84t1bo5 18 15 diabetes diabetes NN cord-018907-c84t1bo5 18 16 . . . cord-018907-c84t1bo5 19 1 The the DT cord-018907-c84t1bo5 19 2 pathogens pathogen NNS cord-018907-c84t1bo5 19 3 in in IN cord-018907-c84t1bo5 19 4 immunocompromised immunocompromised JJ cord-018907-c84t1bo5 19 5 patients patient NNS cord-018907-c84t1bo5 19 6 can can MD cord-018907-c84t1bo5 19 7 be be VB cord-018907-c84t1bo5 19 8 predicted predict VBN cord-018907-c84t1bo5 19 9 based base VBN cord-018907-c84t1bo5 19 10 on on IN cord-018907-c84t1bo5 19 11 the the DT cord-018907-c84t1bo5 19 12 immune immune JJ cord-018907-c84t1bo5 19 13 defect defect NN cord-018907-c84t1bo5 19 14 . . . cord-018907-c84t1bo5 20 1 For for IN cord-018907-c84t1bo5 20 2 example example NN cord-018907-c84t1bo5 20 3 , , , cord-018907-c84t1bo5 20 4 if if IN cord-018907-c84t1bo5 20 5 there there EX cord-018907-c84t1bo5 20 6 is be VBZ cord-018907-c84t1bo5 20 7 an an DT cord-018907-c84t1bo5 20 8 anatomical anatomical JJ cord-018907-c84t1bo5 20 9 disruption disruption NN cord-018907-c84t1bo5 20 10 in in IN cord-018907-c84t1bo5 20 11 the the DT cord-018907-c84t1bo5 20 12 oral oral JJ cord-018907-c84t1bo5 20 13 cavity cavity NN cord-018907-c84t1bo5 20 14 it -PRON- PRP cord-018907-c84t1bo5 20 15 lead lead VBP cord-018907-c84t1bo5 20 16 to to IN cord-018907-c84t1bo5 20 17 infections infection NNS cord-018907-c84t1bo5 20 18 caused cause VBN cord-018907-c84t1bo5 20 19 by by IN cord-018907-c84t1bo5 20 20 alpha alpha NN cord-018907-c84t1bo5 20 21 hemolytic hemolytic JJ cord-018907-c84t1bo5 20 22 streptococci streptococcus NNS cord-018907-c84t1bo5 20 23 , , , cord-018907-c84t1bo5 20 24 anaerobes anaerobe NNS cord-018907-c84t1bo5 20 25 , , , cord-018907-c84t1bo5 20 26 Candida candida NN cord-018907-c84t1bo5 20 27 species specie NNS cord-018907-c84t1bo5 20 28 , , , cord-018907-c84t1bo5 20 29 and and CC cord-018907-c84t1bo5 20 30 herpes herpes NN cord-018907-c84t1bo5 20 31 simplex simplex NNP cord-018907-c84t1bo5 20 32 virus virus NN cord-018907-c84t1bo5 20 33 ( ( -LRB- cord-018907-c84t1bo5 20 34 HSV HSV NNP cord-018907-c84t1bo5 20 35 ) ) -RRB- cord-018907-c84t1bo5 20 36 . . . cord-018907-c84t1bo5 21 1 Patients patient NNS cord-018907-c84t1bo5 21 2 with with IN cord-018907-c84t1bo5 21 3 urinary urinary JJ cord-018907-c84t1bo5 21 4 catheters catheter NNS cord-018907-c84t1bo5 21 5 will will MD cord-018907-c84t1bo5 21 6 be be VB cord-018907-c84t1bo5 21 7 at at IN cord-018907-c84t1bo5 21 8 risk risk NN cord-018907-c84t1bo5 21 9 for for IN cord-018907-c84t1bo5 21 10 infection infection NN cord-018907-c84t1bo5 21 11 caused cause VBN cord-018907-c84t1bo5 21 12 by by IN cord-018907-c84t1bo5 21 13 gram gram NN cord-018907-c84t1bo5 21 14 negative negative JJ cord-018907-c84t1bo5 21 15 bacteria bacteria NNS cord-018907-c84t1bo5 21 16 including include VBG cord-018907-c84t1bo5 21 17 Pseudomonas Pseudomonas NNP cord-018907-c84t1bo5 21 18 spp spp NNS cord-018907-c84t1bo5 21 19 . . . cord-018907-c84t1bo5 22 1 , , , cord-018907-c84t1bo5 22 2 enterococci enterococci NNP cord-018907-c84t1bo5 22 3 , , , cord-018907-c84t1bo5 22 4 and and CC cord-018907-c84t1bo5 22 5 possibly possibly RB cord-018907-c84t1bo5 22 6 candida candida NNP cord-018907-c84t1bo5 22 7 . . . cord-018907-c84t1bo5 23 1 If if IN cord-018907-c84t1bo5 23 2 there there EX cord-018907-c84t1bo5 23 3 is be VBZ cord-018907-c84t1bo5 23 4 a a DT cord-018907-c84t1bo5 23 5 skin skin NN cord-018907-c84t1bo5 23 6 defect defect NN cord-018907-c84t1bo5 23 7 including include VBG cord-018907-c84t1bo5 23 8 central central JJ cord-018907-c84t1bo5 23 9 venous venous JJ cord-018907-c84t1bo5 23 10 catheter catheter NN cord-018907-c84t1bo5 23 11 ( ( -LRB- cord-018907-c84t1bo5 23 12 CVC CVC NNP cord-018907-c84t1bo5 23 13 ) ) -RRB- cord-018907-c84t1bo5 23 14 , , , cord-018907-c84t1bo5 23 15 the the DT cord-018907-c84t1bo5 23 16 patient patient NN cord-018907-c84t1bo5 23 17 will will MD cord-018907-c84t1bo5 23 18 be be VB cord-018907-c84t1bo5 23 19 at at IN cord-018907-c84t1bo5 23 20 risk risk NN cord-018907-c84t1bo5 23 21 of of IN cord-018907-c84t1bo5 23 22 Staphylococcus Staphylococcus NNP cord-018907-c84t1bo5 23 23 species specie NNS cord-018907-c84t1bo5 23 24 ( ( -LRB- cord-018907-c84t1bo5 23 25 both both DT cord-018907-c84t1bo5 23 26 coagulase coagulase NN cord-018907-c84t1bo5 23 27 - - HYPH cord-018907-c84t1bo5 23 28 negative negative JJ cord-018907-c84t1bo5 23 29 staphylococci staphylococcus NNS cord-018907-c84t1bo5 23 30 and and CC cord-018907-c84t1bo5 23 31 Staphylococcus Staphylococcus NNP cord-018907-c84t1bo5 23 32 aureus aureus NN cord-018907-c84t1bo5 23 33 , , , cord-018907-c84t1bo5 23 34 Bacillus bacillus NN cord-018907-c84t1bo5 23 35 species specie NNS cord-018907-c84t1bo5 23 36 , , , cord-018907-c84t1bo5 23 37 atypical atypical JJ cord-018907-c84t1bo5 23 38 Mycobacterium Mycobacterium NNP cord-018907-c84t1bo5 23 39 , , , cord-018907-c84t1bo5 23 40 and and CC cord-018907-c84t1bo5 23 41 Gram gram NN cord-018907-c84t1bo5 23 42 - - HYPH cord-018907-c84t1bo5 23 43 negative negative JJ cord-018907-c84t1bo5 23 44 organism organism NN cord-018907-c84t1bo5 23 45 . . . cord-018907-c84t1bo5 24 1 If if IN cord-018907-c84t1bo5 24 2 a a DT cord-018907-c84t1bo5 24 3 defect defect NN cord-018907-c84t1bo5 24 4 in in IN cord-018907-c84t1bo5 24 5 the the DT cord-018907-c84t1bo5 24 6 phagocytic phagocytic JJ cord-018907-c84t1bo5 24 7 function function NN cord-018907-c84t1bo5 24 8 , , , cord-018907-c84t1bo5 24 9 either either CC cord-018907-c84t1bo5 24 10 quantitative quantitative JJ cord-018907-c84t1bo5 24 11 or or CC cord-018907-c84t1bo5 24 12 qualitative qualitative JJ cord-018907-c84t1bo5 24 13 , , , cord-018907-c84t1bo5 24 14 predispose predispose VB cord-018907-c84t1bo5 24 15 what what WP cord-018907-c84t1bo5 24 16 to to IN cord-018907-c84t1bo5 24 17 invasive invasive JJ cord-018907-c84t1bo5 24 18 diseases disease NNS cord-018907-c84t1bo5 24 19 like like IN cord-018907-c84t1bo5 24 20 invasive invasive JJ cord-018907-c84t1bo5 24 21 pneumonia pneumonia NN cord-018907-c84t1bo5 24 22 caused cause VBN cord-018907-c84t1bo5 24 23 by by IN cord-018907-c84t1bo5 24 24 bacterial bacterial JJ cord-018907-c84t1bo5 24 25 pathogens pathogen NNS cord-018907-c84t1bo5 24 26 : : : cord-018907-c84t1bo5 24 27 Gram gram NN cord-018907-c84t1bo5 24 28 - - HYPH cord-018907-c84t1bo5 24 29 positive positive JJ cord-018907-c84t1bo5 24 30 ( ( -LRB- cord-018907-c84t1bo5 24 31 staphylococci staphylococcus NNS cord-018907-c84t1bo5 24 32 , , , cord-018907-c84t1bo5 24 33 streptococci streptococcus NNS cord-018907-c84t1bo5 24 34 , , , cord-018907-c84t1bo5 24 35 and and CC cord-018907-c84t1bo5 24 36 Nocardia Nocardia NNP cord-018907-c84t1bo5 24 37 species specie NNS cord-018907-c84t1bo5 24 38 ) ) -RRB- cord-018907-c84t1bo5 24 39 and and CC cord-018907-c84t1bo5 24 40 Gram gram NN cord-018907-c84t1bo5 24 41 - - HYPH cord-018907-c84t1bo5 24 42 negative negative JJ cord-018907-c84t1bo5 24 43 bacilli bacilli NN cord-018907-c84t1bo5 24 44 ( ( -LRB- cord-018907-c84t1bo5 24 45 Escherichia escherichia NN cord-018907-c84t1bo5 24 46 coli coli NNS cord-018907-c84t1bo5 24 47 , , , cord-018907-c84t1bo5 24 48 Klebsiella Klebsiella NNP cord-018907-c84t1bo5 24 49 pneumoniae pneumoniae NN cord-018907-c84t1bo5 24 50 , , , cord-018907-c84t1bo5 24 51 P. P. NNP cord-018907-c84t1bo5 24 52 aeruginosa aeruginosa NNP cord-018907-c84t1bo5 24 53 ) ) -RRB- cord-018907-c84t1bo5 24 54 , , , cord-018907-c84t1bo5 24 55 other other JJ cord-018907-c84t1bo5 24 56 enterobacteriaceae enterobacteriaceae NNS cord-018907-c84t1bo5 24 57 , , , cord-018907-c84t1bo5 24 58 and and CC cord-018907-c84t1bo5 24 59 fungal fungal JJ cord-018907-c84t1bo5 24 60 pathogens pathogen NNS cord-018907-c84t1bo5 24 61 like like IN cord-018907-c84t1bo5 24 62 Candida Candida NNP cord-018907-c84t1bo5 24 63 species specie NNS cord-018907-c84t1bo5 24 64 and and CC cord-018907-c84t1bo5 24 65 Aspergillus aspergillus NN cord-018907-c84t1bo5 24 66 species specie NNS cord-018907-c84t1bo5 24 67 . . . cord-018907-c84t1bo5 25 1 Patients patient NNS cord-018907-c84t1bo5 25 2 with with IN cord-018907-c84t1bo5 25 3 defective defective JJ cord-018907-c84t1bo5 25 4 cell cell NN cord-018907-c84t1bo5 25 5 - - HYPH cord-018907-c84t1bo5 25 6 mediated mediate VBN cord-018907-c84t1bo5 25 7 immunity immunity NN cord-018907-c84t1bo5 25 8 are be VBP cord-018907-c84t1bo5 25 9 at at IN cord-018907-c84t1bo5 25 10 risk risk NN cord-018907-c84t1bo5 25 11 of of IN cord-018907-c84t1bo5 25 12 infections infection NNS cord-018907-c84t1bo5 25 13 caused cause VBN cord-018907-c84t1bo5 25 14 by by IN cord-018907-c84t1bo5 25 15 intracellular intracellular JJ cord-018907-c84t1bo5 25 16 pathogens pathogen NNS cord-018907-c84t1bo5 25 17 ( ( -LRB- cord-018907-c84t1bo5 25 18 i.e. i.e. FW cord-018907-c84t1bo5 25 19 , , , cord-018907-c84t1bo5 25 20 viral viral JJ cord-018907-c84t1bo5 25 21 , , , cord-018907-c84t1bo5 25 22 fungi fungus NNS cord-018907-c84t1bo5 25 23 , , , cord-018907-c84t1bo5 25 24 mycobacterial mycobacterial NNP cord-018907-c84t1bo5 25 25 , , , cord-018907-c84t1bo5 25 26 and and CC cord-018907-c84t1bo5 25 27 intracellular intracellular JJ cord-018907-c84t1bo5 25 28 bacteria bacteria NNS cord-018907-c84t1bo5 25 29 ) ) -RRB- cord-018907-c84t1bo5 25 30 . . . cord-018907-c84t1bo5 26 1 Intracellular Intracellular NNP cord-018907-c84t1bo5 26 2 pathogens pathogen NNS cord-018907-c84t1bo5 26 3 include include VBP cord-018907-c84t1bo5 26 4 Legionella Legionella NNP cord-018907-c84t1bo5 26 5 species specie NNS cord-018907-c84t1bo5 26 6 , , , cord-018907-c84t1bo5 26 7 Salmonella salmonella NN cord-018907-c84t1bo5 26 8 species specie NNS cord-018907-c84t1bo5 26 9 , , , cord-018907-c84t1bo5 26 10 Mycobacteria Mycobacteria NNP cord-018907-c84t1bo5 26 11 , , , cord-018907-c84t1bo5 26 12 and and CC cord-018907-c84t1bo5 26 13 Listeria Listeria NNP cord-018907-c84t1bo5 26 14 species specie NNS cord-018907-c84t1bo5 26 15 , , , cord-018907-c84t1bo5 26 16 Histoplasma Histoplasma NNP cord-018907-c84t1bo5 26 17 capsulatum capsulatum NN cord-018907-c84t1bo5 26 18 , , , cord-018907-c84t1bo5 26 19 Coccidioides Coccidioides NNP cord-018907-c84t1bo5 26 20 immitis immitis NNP cord-018907-c84t1bo5 26 21 , , , cord-018907-c84t1bo5 26 22 Cryptococcus Cryptococcus NNP cord-018907-c84t1bo5 26 23 neoformens neoformen NNS cord-018907-c84t1bo5 26 24 , , , cord-018907-c84t1bo5 26 25 Candida Candida NNP cord-018907-c84t1bo5 26 26 species specie NNS cord-018907-c84t1bo5 26 27 , , , cord-018907-c84t1bo5 26 28 Pneumocystis Pneumocystis NNP cord-018907-c84t1bo5 26 29 jiroveci jiroveci NNS cord-018907-c84t1bo5 26 30 , , , cord-018907-c84t1bo5 26 31 cytomegalovirus cytomegalovirus NN cord-018907-c84t1bo5 26 32 , , , cord-018907-c84t1bo5 26 33 Varicella varicella NN cord-018907-c84t1bo5 26 34 - - HYPH cord-018907-c84t1bo5 26 35 zoster zoster NN cord-018907-c84t1bo5 26 36 virus virus NN cord-018907-c84t1bo5 26 37 , , , cord-018907-c84t1bo5 26 38 Epstein Epstein NNP cord-018907-c84t1bo5 26 39 - - HYPH cord-018907-c84t1bo5 26 40 Barr Barr NNP cord-018907-c84t1bo5 26 41 virus virus NN cord-018907-c84t1bo5 26 42 , , , cord-018907-c84t1bo5 26 43 live live VBP cord-018907-c84t1bo5 26 44 viral viral JJ cord-018907-c84t1bo5 26 45 vaccines vaccine NNS cord-018907-c84t1bo5 26 46 ( ( -LRB- cord-018907-c84t1bo5 26 47 measles measle NNS cord-018907-c84t1bo5 26 48 , , , cord-018907-c84t1bo5 26 49 mumps mumps NN cord-018907-c84t1bo5 26 50 , , , cord-018907-c84t1bo5 26 51 rubella rubella NN cord-018907-c84t1bo5 26 52 , , , cord-018907-c84t1bo5 26 53 and and CC cord-018907-c84t1bo5 26 54 polio polio NN cord-018907-c84t1bo5 26 55 ) ) -RRB- cord-018907-c84t1bo5 26 56 and and CC cord-018907-c84t1bo5 26 57 protozoal protozoal NNP cord-018907-c84t1bo5 26 58 , , , cord-018907-c84t1bo5 26 59 Toxoplasma toxoplasma NN cord-018907-c84t1bo5 26 60 gondii gondii NN cord-018907-c84t1bo5 26 61 , , , cord-018907-c84t1bo5 26 62 Strongyloides Strongyloides NNP cord-018907-c84t1bo5 26 63 stercoralis stercoralis NNP cord-018907-c84t1bo5 26 64 , , , cord-018907-c84t1bo5 26 65 Cryptosporidia Cryptosporidia NNP cord-018907-c84t1bo5 26 66 , , , cord-018907-c84t1bo5 26 67 Microsporidia Microsporidia NNP cord-018907-c84t1bo5 26 68 , , , cord-018907-c84t1bo5 26 69 and and CC cord-018907-c84t1bo5 26 70 Isospora Isospora NNP cord-018907-c84t1bo5 26 71 species specie NNS cord-018907-c84t1bo5 26 72 . . . cord-018907-c84t1bo5 27 1 Patients patient NNS cord-018907-c84t1bo5 27 2 with with IN cord-018907-c84t1bo5 27 3 immunoglobulin immunoglobulin NN cord-018907-c84t1bo5 27 4 deficiencyo deficiencyo NN cord-018907-c84t1bo5 27 5 are be VBP cord-018907-c84t1bo5 27 6 at at IN cord-018907-c84t1bo5 27 7 risk risk NN cord-018907-c84t1bo5 27 8 of of IN cord-018907-c84t1bo5 27 9 sinupulmonary sinupulmonary JJ cord-018907-c84t1bo5 27 10 infection infection NN cord-018907-c84t1bo5 27 11 caused cause VBN cord-018907-c84t1bo5 27 12 by by IN cord-018907-c84t1bo5 27 13 S. S. NNP cord-018907-c84t1bo5 27 14 pneumoniae pneumoniae NN cord-018907-c84t1bo5 27 15 , , , cord-018907-c84t1bo5 27 16 Haemophilus haemophilus JJ cord-018907-c84t1bo5 27 17 influenzae influenzae NN cord-018907-c84t1bo5 27 18 , , , cord-018907-c84t1bo5 27 19 and and CC cord-018907-c84t1bo5 27 20 CNS cns JJ cord-018907-c84t1bo5 27 21 infection infection NN cord-018907-c84t1bo5 27 22 from from IN cord-018907-c84t1bo5 27 23 viral viral JJ cord-018907-c84t1bo5 27 24 infections infection NNS cord-018907-c84t1bo5 27 25 , , , cord-018907-c84t1bo5 27 26 especially especially RB cord-018907-c84t1bo5 27 27 enterovirus enterovirus NN cord-018907-c84t1bo5 27 28 , , , cord-018907-c84t1bo5 27 29 leading lead VBG cord-018907-c84t1bo5 27 30 to to IN cord-018907-c84t1bo5 27 31 chronic chronic JJ cord-018907-c84t1bo5 27 32 meningoencephalitis meningoencephalitis NNP cord-018907-c84t1bo5 27 33 as as RB cord-018907-c84t1bo5 27 34 well well RB cord-018907-c84t1bo5 27 35 as as IN cord-018907-c84t1bo5 27 36 gastrointestinal gastrointestinal JJ cord-018907-c84t1bo5 27 37 infection infection NN cord-018907-c84t1bo5 27 38 due due IN cord-018907-c84t1bo5 27 39 to to IN cord-018907-c84t1bo5 27 40 giardiasis giardiasis NN cord-018907-c84t1bo5 27 41 . . . cord-018907-c84t1bo5 28 1 Patients patient NNS cord-018907-c84t1bo5 28 2 with with IN cord-018907-c84t1bo5 28 3 complement complement JJ cord-018907-c84t1bo5 28 4 deficiency deficiency NN cord-018907-c84t1bo5 28 5 are be VBP cord-018907-c84t1bo5 28 6 at at IN cord-018907-c84t1bo5 28 7 risk risk NN cord-018907-c84t1bo5 28 8 of of IN cord-018907-c84t1bo5 28 9 diseases disease NNS cord-018907-c84t1bo5 28 10 caused cause VBN cord-018907-c84t1bo5 28 11 by by IN cord-018907-c84t1bo5 28 12 S. S. NNP cord-018907-c84t1bo5 28 13 pneumoniae pneumoniae NN cord-018907-c84t1bo5 28 14 , , , cord-018907-c84t1bo5 28 15 H. H. NNP cord-018907-c84t1bo5 28 16 influenzae influenzae NN cord-018907-c84t1bo5 28 17 , , , cord-018907-c84t1bo5 28 18 and and CC cord-018907-c84t1bo5 28 19 Neisseria Neisseria NNP cord-018907-c84t1bo5 28 20 species specie NNS cord-018907-c84t1bo5 28 21 . . . cord-018907-c84t1bo5 29 1 Splenectomized splenectomized JJ cord-018907-c84t1bo5 29 2 patients patient NNS cord-018907-c84t1bo5 29 3 are be VBP cord-018907-c84t1bo5 29 4 at at IN cord-018907-c84t1bo5 29 5 risk risk NN cord-018907-c84t1bo5 29 6 of of IN cord-018907-c84t1bo5 29 7 invasive invasive JJ cord-018907-c84t1bo5 29 8 diseases disease NNS cord-018907-c84t1bo5 29 9 ( ( -LRB- cord-018907-c84t1bo5 29 10 e.g. e.g. RB cord-018907-c84t1bo5 29 11 , , , cord-018907-c84t1bo5 29 12 sepsis sepsis NN cord-018907-c84t1bo5 29 13 , , , cord-018907-c84t1bo5 29 14 meningitis meningitis NN cord-018907-c84t1bo5 29 15 ) ) -RRB- cord-018907-c84t1bo5 29 16 caused cause VBN cord-018907-c84t1bo5 29 17 by by IN cord-018907-c84t1bo5 29 18 encapsulated encapsulate VBN cord-018907-c84t1bo5 29 19 organism organism NN cord-018907-c84t1bo5 29 20 including include VBG cord-018907-c84t1bo5 29 21 S. S. NNP cord-018907-c84t1bo5 29 22 pneumoniae pneumoniae NN cord-018907-c84t1bo5 29 23 , , , cord-018907-c84t1bo5 29 24 H. H. NNP cord-018907-c84t1bo5 29 25 influenzae influenzae NN cord-018907-c84t1bo5 29 26 , , , cord-018907-c84t1bo5 29 27 and and CC cord-018907-c84t1bo5 29 28 Neisseria Neisseria NNP cord-018907-c84t1bo5 29 29 meningitidis meningitidis NNP cord-018907-c84t1bo5 29 30 . . . cord-018907-c84t1bo5 30 1 In in IN cord-018907-c84t1bo5 30 2 evaluating evaluate VBG cord-018907-c84t1bo5 30 3 patients patient NNS cord-018907-c84t1bo5 30 4 with with IN cord-018907-c84t1bo5 30 5 immunodeficiency immunodeficiency NN cord-018907-c84t1bo5 30 6 , , , cord-018907-c84t1bo5 30 7 one one PRP cord-018907-c84t1bo5 30 8 can can MD cord-018907-c84t1bo5 30 9 predict predict VB cord-018907-c84t1bo5 30 10 the the DT cord-018907-c84t1bo5 30 11 pathogen pathogen NN cord-018907-c84t1bo5 30 12 based base VBN cord-018907-c84t1bo5 30 13 on on IN cord-018907-c84t1bo5 30 14 the the DT cord-018907-c84t1bo5 30 15 primary primary JJ cord-018907-c84t1bo5 30 16 immune immune JJ cord-018907-c84t1bo5 30 17 defects defect NNS cord-018907-c84t1bo5 30 18 , , , cord-018907-c84t1bo5 30 19 the the DT cord-018907-c84t1bo5 30 20 organs organ NNS cord-018907-c84t1bo5 30 21 involved involve VBN cord-018907-c84t1bo5 30 22 , , , cord-018907-c84t1bo5 30 23 and and CC cord-018907-c84t1bo5 30 24 the the DT cord-018907-c84t1bo5 30 25 clinical clinical JJ cord-018907-c84t1bo5 30 26 presentation presentation NN cord-018907-c84t1bo5 30 27 of of IN cord-018907-c84t1bo5 30 28 the the DT cord-018907-c84t1bo5 30 29 patient patient NN cord-018907-c84t1bo5 30 30 . . . cord-018907-c84t1bo5 31 1 For for IN cord-018907-c84t1bo5 31 2 instance instance NN cord-018907-c84t1bo5 31 3 , , , cord-018907-c84t1bo5 31 4 Staphylococcus Staphylococcus NNP cord-018907-c84t1bo5 31 5 aureus aureus NN cord-018907-c84t1bo5 31 6 , , , cord-018907-c84t1bo5 31 7 Burkholderia Burkholderia NNP cord-018907-c84t1bo5 31 8 cepacia cepacia NNP cord-018907-c84t1bo5 31 9 , , , cord-018907-c84t1bo5 31 10 Serratia Serratia NNP cord-018907-c84t1bo5 31 11 marcescens marcescen NNS cord-018907-c84t1bo5 31 12 , , , cord-018907-c84t1bo5 31 13 Pseudomonas Pseudomonas NNP cord-018907-c84t1bo5 31 14 and and CC cord-018907-c84t1bo5 31 15 aspergillous aspergillous JJ cord-018907-c84t1bo5 31 16 infection infection NN cord-018907-c84t1bo5 31 17 should should MD cord-018907-c84t1bo5 31 18 be be VB cord-018907-c84t1bo5 31 19 considered consider VBN cord-018907-c84t1bo5 31 20 for for IN cord-018907-c84t1bo5 31 21 a a DT cord-018907-c84t1bo5 31 22 chronic chronic JJ cord-018907-c84t1bo5 31 23 granulomatous granulomatous JJ cord-018907-c84t1bo5 31 24 diseased disease VBN cord-018907-c84t1bo5 31 25 ( ( -LRB- cord-018907-c84t1bo5 31 26 CGD CGD NNP cord-018907-c84t1bo5 31 27 ) ) -RRB- cord-018907-c84t1bo5 31 28 patient patient JJ cord-018907-c84t1bo5 31 29 with with IN cord-018907-c84t1bo5 31 30 soft soft JJ cord-018907-c84t1bo5 31 31 tissue tissue NN cord-018907-c84t1bo5 31 32 infection infection NN cord-018907-c84t1bo5 31 33 , , , cord-018907-c84t1bo5 31 34 lymphadenitis lymphadenitis NNP cord-018907-c84t1bo5 31 35 , , , cord-018907-c84t1bo5 31 36 liver liver NN cord-018907-c84t1bo5 31 37 abscess abscess NN cord-018907-c84t1bo5 31 38 , , , cord-018907-c84t1bo5 31 39 osteomyelitis osteomyelitis NN cord-018907-c84t1bo5 31 40 , , , cord-018907-c84t1bo5 31 41 pneumonia pneumonia NN cord-018907-c84t1bo5 31 42 , , , cord-018907-c84t1bo5 31 43 and and CC cord-018907-c84t1bo5 31 44 sepsis sepsis NN cord-018907-c84t1bo5 31 45 . . . cord-018907-c84t1bo5 32 1 In in IN cord-018907-c84t1bo5 32 2 centers center NNS cord-018907-c84t1bo5 32 3 dealing deal VBG cord-018907-c84t1bo5 32 4 with with IN cord-018907-c84t1bo5 32 5 immunocompromised immunocompromised JJ cord-018907-c84t1bo5 32 6 patients patient NNS cord-018907-c84t1bo5 32 7 , , , cord-018907-c84t1bo5 32 8 the the DT cord-018907-c84t1bo5 32 9 microbiology microbiology NN cord-018907-c84t1bo5 32 10 laboratory laboratory NN cord-018907-c84t1bo5 32 11 as as RB cord-018907-c84t1bo5 32 12 well well RB cord-018907-c84t1bo5 32 13 as as IN cord-018907-c84t1bo5 32 14 the the DT cord-018907-c84t1bo5 32 15 radiology radiology NN cord-018907-c84t1bo5 32 16 service service NN cord-018907-c84t1bo5 32 17 need need VBP cord-018907-c84t1bo5 32 18 to to TO cord-018907-c84t1bo5 32 19 be be VB cord-018907-c84t1bo5 32 20 well well RB cord-018907-c84t1bo5 32 21 equipped equipped JJ cord-018907-c84t1bo5 32 22 and and CC cord-018907-c84t1bo5 32 23 trained train VBN cord-018907-c84t1bo5 32 24 in in IN cord-018907-c84t1bo5 32 25 diagnosing diagnose VBG cord-018907-c84t1bo5 32 26 these these DT cord-018907-c84t1bo5 32 27 patients patient NNS cord-018907-c84t1bo5 32 28 . . . cord-018907-c84t1bo5 33 1 Patients patient NNS cord-018907-c84t1bo5 33 2 with with IN cord-018907-c84t1bo5 33 3 fever fever NN cord-018907-c84t1bo5 33 4 should should MD cord-018907-c84t1bo5 33 5 be be VB cord-018907-c84t1bo5 33 6 worked work VBN cord-018907-c84t1bo5 33 7 up up RP cord-018907-c84t1bo5 33 8 with with IN cord-018907-c84t1bo5 33 9 complete complete JJ cord-018907-c84t1bo5 33 10 blood blood NN cord-018907-c84t1bo5 33 11 count count NN cord-018907-c84t1bo5 33 12 with with IN cord-018907-c84t1bo5 33 13 differential differential JJ cord-018907-c84t1bo5 33 14 , , , cord-018907-c84t1bo5 33 15 renal renal JJ cord-018907-c84t1bo5 33 16 , , , cord-018907-c84t1bo5 33 17 and and CC cord-018907-c84t1bo5 33 18 hepatic hepatic JJ cord-018907-c84t1bo5 33 19 profile profile NN cord-018907-c84t1bo5 33 20 , , , cord-018907-c84t1bo5 33 21 blood blood NN cord-018907-c84t1bo5 33 22 culture culture NN cord-018907-c84t1bo5 33 23 from from IN cord-018907-c84t1bo5 33 24 central central JJ cord-018907-c84t1bo5 33 25 line line NN cord-018907-c84t1bo5 33 26 ( ( -LRB- cord-018907-c84t1bo5 33 27 if if IN cord-018907-c84t1bo5 33 28 present present JJ cord-018907-c84t1bo5 33 29 ) ) -RRB- cord-018907-c84t1bo5 33 30 , , , cord-018907-c84t1bo5 33 31 and and CC cord-018907-c84t1bo5 33 32 peripheral peripheral JJ cord-018907-c84t1bo5 33 33 culture culture NN cord-018907-c84t1bo5 33 34 . . . cord-018907-c84t1bo5 34 1 Chest chest NN cord-018907-c84t1bo5 34 2 X X NNS cord-018907-c84t1bo5 34 3 - - NNS cord-018907-c84t1bo5 34 4 rays ray NNS cord-018907-c84t1bo5 34 5 are be VBP cord-018907-c84t1bo5 34 6 not not RB cord-018907-c84t1bo5 34 7 done do VBN cord-018907-c84t1bo5 34 8 routinely routinely RB cord-018907-c84t1bo5 34 9 unless unless IN cord-018907-c84t1bo5 34 10 the the DT cord-018907-c84t1bo5 34 11 patients patient NNS cord-018907-c84t1bo5 34 12 have have VBP cord-018907-c84t1bo5 34 13 respiratory respiratory JJ cord-018907-c84t1bo5 34 14 symptoms symptom NNS cord-018907-c84t1bo5 34 15 . . . cord-018907-c84t1bo5 35 1 Other other JJ cord-018907-c84t1bo5 35 2 investigations investigation NNS cord-018907-c84t1bo5 35 3 need need VBP cord-018907-c84t1bo5 35 4 to to TO cord-018907-c84t1bo5 35 5 be be VB cord-018907-c84t1bo5 35 6 guided guide VBN cord-018907-c84t1bo5 35 7 by by IN cord-018907-c84t1bo5 35 8 the the DT cord-018907-c84t1bo5 35 9 presentation presentation NN cord-018907-c84t1bo5 35 10 of of IN cord-018907-c84t1bo5 35 11 the the DT cord-018907-c84t1bo5 35 12 patient patient NN cord-018907-c84t1bo5 35 13 . . . cord-018907-c84t1bo5 36 1 Patients patient NNS cord-018907-c84t1bo5 36 2 with with IN cord-018907-c84t1bo5 36 3 diarrhea diarrhea NN cord-018907-c84t1bo5 36 4 should should MD cord-018907-c84t1bo5 36 5 have have VB cord-018907-c84t1bo5 36 6 stool stool NN cord-018907-c84t1bo5 36 7 checked check VBN cord-018907-c84t1bo5 36 8 for for IN cord-018907-c84t1bo5 36 9 bacterial bacterial JJ cord-018907-c84t1bo5 36 10 culture culture NN cord-018907-c84t1bo5 36 11 , , , cord-018907-c84t1bo5 36 12 ova ova NN cord-018907-c84t1bo5 36 13 and and CC cord-018907-c84t1bo5 36 14 parasite parasite NN cord-018907-c84t1bo5 36 15 , , , cord-018907-c84t1bo5 36 16 viral viral JJ cord-018907-c84t1bo5 36 17 culture culture NN cord-018907-c84t1bo5 36 18 , , , cord-018907-c84t1bo5 36 19 rotavirus rotavirus NN cord-018907-c84t1bo5 36 20 , , , cord-018907-c84t1bo5 36 21 and and CC cord-018907-c84t1bo5 36 22 electron electron NN cord-018907-c84t1bo5 36 23 microscopy microscopy NN cord-018907-c84t1bo5 36 24 for for IN cord-018907-c84t1bo5 36 25 viral viral JJ cord-018907-c84t1bo5 36 26 studies study NNS cord-018907-c84t1bo5 36 27 , , , cord-018907-c84t1bo5 36 28 in in IN cord-018907-c84t1bo5 36 29 addition addition NN cord-018907-c84t1bo5 36 30 to to IN cord-018907-c84t1bo5 36 31 microspora microspora NNP cord-018907-c84t1bo5 36 32 , , , cord-018907-c84t1bo5 36 33 cryptosporidium cryptosporidium NN cord-018907-c84t1bo5 36 34 , , , cord-018907-c84t1bo5 36 35 and and CC cord-018907-c84t1bo5 36 36 isospora isospora NNP cord-018907-c84t1bo5 36 37 . . . cord-018907-c84t1bo5 37 1 In in IN cord-018907-c84t1bo5 37 2 addition addition NN cord-018907-c84t1bo5 37 3 to to IN cord-018907-c84t1bo5 37 4 chest chest NN cord-018907-c84t1bo5 37 5 X x NN cord-018907-c84t1bo5 37 6 - - NN cord-018907-c84t1bo5 37 7 ray ray NN cord-018907-c84t1bo5 37 8 , , , cord-018907-c84t1bo5 37 9 patients patient NNS cord-018907-c84t1bo5 37 10 with with IN cord-018907-c84t1bo5 37 11 respiratory respiratory JJ cord-018907-c84t1bo5 37 12 symptoms symptom NNS cord-018907-c84t1bo5 37 13 required require VBD cord-018907-c84t1bo5 37 14 nasopharyngeal nasopharyngeal JJ cord-018907-c84t1bo5 37 15 aspirate aspirate NN cord-018907-c84t1bo5 37 16 for for IN cord-018907-c84t1bo5 37 17 rapid rapid JJ cord-018907-c84t1bo5 37 18 test test NN cord-018907-c84t1bo5 37 19 for for IN cord-018907-c84t1bo5 37 20 viruses virus NNS cord-018907-c84t1bo5 37 21 and and CC cord-018907-c84t1bo5 37 22 PCR PCR NNP cord-018907-c84t1bo5 37 23 multiplex multiplex NN cord-018907-c84t1bo5 37 24 -a -a : cord-018907-c84t1bo5 37 25 newly newly RB cord-018907-c84t1bo5 37 26 developed develop VBN cord-018907-c84t1bo5 37 27 laboratory laboratory NN cord-018907-c84t1bo5 37 28 procedure procedure NN cord-018907-c84t1bo5 37 29 that that WDT cord-018907-c84t1bo5 37 30 can can MD cord-018907-c84t1bo5 37 31 screen screen VB cord-018907-c84t1bo5 37 32 multiple multiple JJ cord-018907-c84t1bo5 37 33 viruses virus NNS cord-018907-c84t1bo5 37 34 and and CC cord-018907-c84t1bo5 37 35 other other JJ cord-018907-c84t1bo5 37 36 respiratory respiratory JJ cord-018907-c84t1bo5 37 37 pathogens pathogen NNS cord-018907-c84t1bo5 37 38 in in IN cord-018907-c84t1bo5 37 39 the the DT cord-018907-c84t1bo5 37 40 same same JJ cord-018907-c84t1bo5 37 41 setting setting NN cord-018907-c84t1bo5 37 42 . . . cord-018907-c84t1bo5 38 1 Patients patient NNS cord-018907-c84t1bo5 38 2 with with IN cord-018907-c84t1bo5 38 3 skin skin NN cord-018907-c84t1bo5 38 4 lesions lesion NNS cord-018907-c84t1bo5 38 5 should should MD cord-018907-c84t1bo5 38 6 have have VB cord-018907-c84t1bo5 38 7 skin skin NN cord-018907-c84t1bo5 38 8 biopsy biopsy NN cord-018907-c84t1bo5 38 9 from from IN cord-018907-c84t1bo5 38 10 the the DT cord-018907-c84t1bo5 38 11 lesion lesion NN cord-018907-c84t1bo5 38 12 , , , cord-018907-c84t1bo5 38 13 which which WDT cord-018907-c84t1bo5 38 14 will will MD cord-018907-c84t1bo5 38 15 be be VB cord-018907-c84t1bo5 38 16 sent send VBN cord-018907-c84t1bo5 38 17 for for IN cord-018907-c84t1bo5 38 18 culture culture NN cord-018907-c84t1bo5 38 19 ( ( -LRB- cord-018907-c84t1bo5 38 20 bacterial bacterial JJ cord-018907-c84t1bo5 38 21 , , , cord-018907-c84t1bo5 38 22 fungal fungal JJ cord-018907-c84t1bo5 38 23 , , , cord-018907-c84t1bo5 38 24 and and CC cord-018907-c84t1bo5 38 25 mycobacterium mycobacterium NN cord-018907-c84t1bo5 38 26 ) ) -RRB- cord-018907-c84t1bo5 38 27 in in IN cord-018907-c84t1bo5 38 28 addition addition NN cord-018907-c84t1bo5 38 29 to to IN cord-018907-c84t1bo5 38 30 histopathology histopathology NN cord-018907-c84t1bo5 38 31 for for IN cord-018907-c84t1bo5 38 32 Gram gram NN cord-018907-c84t1bo5 38 33 - - HYPH cord-018907-c84t1bo5 38 34 stain stain NN cord-018907-c84t1bo5 38 35 and and CC cord-018907-c84t1bo5 38 36 special special JJ cord-018907-c84t1bo5 38 37 staining staining NN cord-018907-c84t1bo5 38 38 for for IN cord-018907-c84t1bo5 38 39 fungal fungal NN cord-018907-c84t1bo5 38 40 as as RB cord-018907-c84t1bo5 38 41 well well RB cord-018907-c84t1bo5 38 42 as as IN cord-018907-c84t1bo5 38 43 acid acid NN cord-018907-c84t1bo5 38 44 fast fast JJ cord-018907-c84t1bo5 38 45 stain stain NN cord-018907-c84t1bo5 38 46 ( ( -LRB- cord-018907-c84t1bo5 38 47 AFB AFB NNP cord-018907-c84t1bo5 38 48 stain stain NN cord-018907-c84t1bo5 38 49 ) ) -RRB- cord-018907-c84t1bo5 38 50 . . . cord-018907-c84t1bo5 39 1 There there EX cord-018907-c84t1bo5 39 2 are be VBP cord-018907-c84t1bo5 39 3 several several JJ cord-018907-c84t1bo5 39 4 objectives objective NNS cord-018907-c84t1bo5 39 5 in in IN cord-018907-c84t1bo5 39 6 managing manage VBG cord-018907-c84t1bo5 39 7 infections infection NNS cord-018907-c84t1bo5 39 8 in in IN cord-018907-c84t1bo5 39 9 immunocompromised immunocompromised JJ cord-018907-c84t1bo5 39 10 patients patient NNS cord-018907-c84t1bo5 39 11 . . . cord-018907-c84t1bo5 40 1 The the DT cord-018907-c84t1bo5 40 2 first first JJ cord-018907-c84t1bo5 40 3 and and CC cord-018907-c84t1bo5 40 4 foremost foremost JJ cord-018907-c84t1bo5 40 5 objective objective NN cord-018907-c84t1bo5 40 6 is be VBZ cord-018907-c84t1bo5 40 7 to to TO cord-018907-c84t1bo5 40 8 assure assure VB cord-018907-c84t1bo5 40 9 patients patient NNS cord-018907-c84t1bo5 40 10 ' ' POS cord-018907-c84t1bo5 40 11 survival survival NN cord-018907-c84t1bo5 40 12 and and CC cord-018907-c84t1bo5 40 13 prevent prevent VB cord-018907-c84t1bo5 40 14 infectious infectious JJ cord-018907-c84t1bo5 40 15 morbidity morbidity NN cord-018907-c84t1bo5 40 16 . . . cord-018907-c84t1bo5 41 1 Decrease decrease NN cord-018907-c84t1bo5 41 2 days day NNS cord-018907-c84t1bo5 41 3 of of IN cord-018907-c84t1bo5 41 4 hospitalization hospitalization NN cord-018907-c84t1bo5 41 5 and and CC cord-018907-c84t1bo5 41 6 decrease decrease VB cord-018907-c84t1bo5 41 7 exposure exposure NN cord-018907-c84t1bo5 41 8 to to IN cord-018907-c84t1bo5 41 9 multidrug multidrug NN cord-018907-c84t1bo5 41 10 resistance resistance NN cord-018907-c84t1bo5 41 11 organism organism NN cord-018907-c84t1bo5 41 12 , , , cord-018907-c84t1bo5 41 13 decrease decrease VB cord-018907-c84t1bo5 41 14 number number NN cord-018907-c84t1bo5 41 15 of of IN cord-018907-c84t1bo5 41 16 days day NNS cord-018907-c84t1bo5 41 17 of of IN cord-018907-c84t1bo5 41 18 antibiotic antibiotic JJ cord-018907-c84t1bo5 41 19 use use NN cord-018907-c84t1bo5 41 20 to to TO cord-018907-c84t1bo5 41 21 minimize minimize VB cord-018907-c84t1bo5 41 22 selection selection NN cord-018907-c84t1bo5 41 23 of of IN cord-018907-c84t1bo5 41 24 resistance resistance NN cord-018907-c84t1bo5 41 25 organism organism NN cord-018907-c84t1bo5 41 26 . . . cord-018907-c84t1bo5 42 1 Modification modification NN cord-018907-c84t1bo5 42 2 of of IN cord-018907-c84t1bo5 42 3 antimicrobial antimicrobial JJ cord-018907-c84t1bo5 42 4 therapy therapy NN cord-018907-c84t1bo5 42 5 in in IN cord-018907-c84t1bo5 42 6 immunocompromised immunocompromised JJ cord-018907-c84t1bo5 42 7 patients patient NNS cord-018907-c84t1bo5 42 8 is be VBZ cord-018907-c84t1bo5 42 9 the the DT cord-018907-c84t1bo5 42 10 rule rule NN cord-018907-c84t1bo5 42 11 rather rather RB cord-018907-c84t1bo5 42 12 than than IN cord-018907-c84t1bo5 42 13 the the DT cord-018907-c84t1bo5 42 14 exception exception NN cord-018907-c84t1bo5 42 15 . . . cord-018907-c84t1bo5 43 1 Timely timely JJ cord-018907-c84t1bo5 43 2 modification modification NN cord-018907-c84t1bo5 43 3 of of IN cord-018907-c84t1bo5 43 4 antibiotic antibiotic JJ cord-018907-c84t1bo5 43 5 therapy therapy NN cord-018907-c84t1bo5 43 6 is be VBZ cord-018907-c84t1bo5 43 7 very very RB cord-018907-c84t1bo5 43 8 important important JJ cord-018907-c84t1bo5 43 9 to to TO cord-018907-c84t1bo5 43 10 control control VB cord-018907-c84t1bo5 43 11 breakthrough breakthrough NN cord-018907-c84t1bo5 43 12 infection infection NN cord-018907-c84t1bo5 43 13 . . . cord-018907-c84t1bo5 44 1 There there EX cord-018907-c84t1bo5 44 2 are be VBP cord-018907-c84t1bo5 44 3 several several JJ cord-018907-c84t1bo5 44 4 questions question NNS cord-018907-c84t1bo5 44 5 to to TO cord-018907-c84t1bo5 44 6 be be VB cord-018907-c84t1bo5 44 7 addressed address VBN cord-018907-c84t1bo5 44 8 to to TO cord-018907-c84t1bo5 44 9 choose choose VB cord-018907-c84t1bo5 44 10 the the DT cord-018907-c84t1bo5 44 11 effective effective JJ cord-018907-c84t1bo5 44 12 antimicrobial antimicrobial JJ cord-018907-c84t1bo5 44 13 therapy therapy NN cord-018907-c84t1bo5 44 14 when when WRB cord-018907-c84t1bo5 44 15 evaluating evaluate VBG cord-018907-c84t1bo5 44 16 patients patient NNS cord-018907-c84t1bo5 44 17 . . . cord-018907-c84t1bo5 45 1 In in IN cord-018907-c84t1bo5 45 2 addition addition NN cord-018907-c84t1bo5 45 3 to to IN cord-018907-c84t1bo5 45 4 history history NN cord-018907-c84t1bo5 45 5 and and CC cord-018907-c84t1bo5 45 6 physical physical JJ cord-018907-c84t1bo5 45 7 examination examination NN cord-018907-c84t1bo5 45 8 , , , cord-018907-c84t1bo5 45 9 it -PRON- PRP cord-018907-c84t1bo5 45 10 is be VBZ cord-018907-c84t1bo5 45 11 important important JJ cord-018907-c84t1bo5 45 12 to to TO cord-018907-c84t1bo5 45 13 determine determine VB cord-018907-c84t1bo5 45 14 which which WDT cord-018907-c84t1bo5 45 15 arm arm NN cord-018907-c84t1bo5 45 16 / / SYM cord-018907-c84t1bo5 45 17 arms arm NNS cord-018907-c84t1bo5 45 18 of of IN cord-018907-c84t1bo5 45 19 the the DT cord-018907-c84t1bo5 45 20 immune immune JJ cord-018907-c84t1bo5 45 21 systems system NNS cord-018907-c84t1bo5 46 1 that that DT cord-018907-c84t1bo5 46 2 is be VBZ cord-018907-c84t1bo5 46 3 / / , cord-018907-c84t1bo5 46 4 are be VBP cord-018907-c84t1bo5 46 5 affected affect VBN cord-018907-c84t1bo5 46 6 ? ? . cord-018907-c84t1bo5 47 1 what what WP cord-018907-c84t1bo5 47 2 the the DT cord-018907-c84t1bo5 47 3 clinical clinical JJ cord-018907-c84t1bo5 47 4 syndrome syndrome NN cord-018907-c84t1bo5 47 5 / / SYM cord-018907-c84t1bo5 47 6 site site NN cord-018907-c84t1bo5 47 7 of of IN cord-018907-c84t1bo5 47 8 infection infection NN cord-018907-c84t1bo5 47 9 is be VBZ cord-018907-c84t1bo5 47 10 ? ? . cord-018907-c84t1bo5 48 1 ( ( -LRB- cord-018907-c84t1bo5 48 2 to to TO cord-018907-c84t1bo5 48 3 predict predict VB cord-018907-c84t1bo5 48 4 what what WP cord-018907-c84t1bo5 48 5 are be VBP cord-018907-c84t1bo5 48 6 the the DT cord-018907-c84t1bo5 48 7 likely likely JJ cord-018907-c84t1bo5 48 8 pathogens pathogen NNS cord-018907-c84t1bo5 48 9 ) ) -RRB- cord-018907-c84t1bo5 48 10 , , , cord-018907-c84t1bo5 48 11 what what WDT cord-018907-c84t1bo5 48 12 clinical clinical JJ cord-018907-c84t1bo5 48 13 specimen(s specimen(s NNP cord-018907-c84t1bo5 48 14 ) ) -RRB- cord-018907-c84t1bo5 48 15 should should MD cord-018907-c84t1bo5 48 16 be be VB cord-018907-c84t1bo5 48 17 obtained obtain VBN cord-018907-c84t1bo5 48 18 ( ( -LRB- cord-018907-c84t1bo5 48 19 empiric empiric JJ cord-018907-c84t1bo5 48 20 / / SYM cord-018907-c84t1bo5 48 21 definitive definitive JJ cord-018907-c84t1bo5 48 22 therapy therapy NN cord-018907-c84t1bo5 48 23 ) ) -RRB- cord-018907-c84t1bo5 48 24 ? ? . cord-018907-c84t1bo5 49 1 and and CC cord-018907-c84t1bo5 49 2 which which WDT cord-018907-c84t1bo5 49 3 antimicrobial antimicrobial JJ cord-018907-c84t1bo5 49 4 agents agent NNS cord-018907-c84t1bo5 49 5 have have VBP cord-018907-c84t1bo5 49 6 predictable predictable JJ cord-018907-c84t1bo5 49 7 activity activity NN cord-018907-c84t1bo5 49 8 against against IN cord-018907-c84t1bo5 49 9 pathogens pathogen NNS cord-018907-c84t1bo5 49 10 ? ? . cord-018907-c84t1bo5 50 1 With with IN cord-018907-c84t1bo5 50 2 these these DT cord-018907-c84t1bo5 50 3 in in IN cord-018907-c84t1bo5 50 4 mind mind NN cord-018907-c84t1bo5 50 5 , , , cord-018907-c84t1bo5 50 6 one one PRP cord-018907-c84t1bo5 50 7 can can MD cord-018907-c84t1bo5 50 8 predict predict VB cord-018907-c84t1bo5 50 9 pathogen pathogen NN cord-018907-c84t1bo5 50 10 and and CC cord-018907-c84t1bo5 50 11 choose choose VB cord-018907-c84t1bo5 50 12 the the DT cord-018907-c84t1bo5 50 13 right right JJ cord-018907-c84t1bo5 50 14 antimicrobial antimicrobial JJ cord-018907-c84t1bo5 50 15 agents agent NNS cord-018907-c84t1bo5 50 16 . . . cord-018907-c84t1bo5 51 1 Patients patient NNS cord-018907-c84t1bo5 51 2 with with IN cord-018907-c84t1bo5 51 3 Wiskott Wiskott NNP cord-018907-c84t1bo5 51 4 - - HYPH cord-018907-c84t1bo5 51 5 Aldrich Aldrich NNP cord-018907-c84t1bo5 51 6 syndrome syndrome NN cord-018907-c84t1bo5 51 7 are be VBP cord-018907-c84t1bo5 51 8 at at IN cord-018907-c84t1bo5 51 9 risk risk NN cord-018907-c84t1bo5 51 10 of of IN cord-018907-c84t1bo5 51 11 bacterial bacterial JJ cord-018907-c84t1bo5 51 12 pneumonia pneumonia NN cord-018907-c84t1bo5 51 13 as as RB cord-018907-c84t1bo5 51 14 well well RB cord-018907-c84t1bo5 51 15 as as IN cord-018907-c84t1bo5 51 16 sepsis sepsis NN cord-018907-c84t1bo5 51 17 with with IN cord-018907-c84t1bo5 51 18 Gram gram NN cord-018907-c84t1bo5 51 19 - - HYPH cord-018907-c84t1bo5 51 20 positive positive JJ cord-018907-c84t1bo5 51 21 organisms organism NNS cord-018907-c84t1bo5 51 22 including include VBG cord-018907-c84t1bo5 51 23 MRSA MRSA NNP cord-018907-c84t1bo5 51 24 . . . cord-018907-c84t1bo5 52 1 In in IN cord-018907-c84t1bo5 52 2 this this DT cord-018907-c84t1bo5 52 3 situation situation NN cord-018907-c84t1bo5 52 4 , , , cord-018907-c84t1bo5 52 5 medication medication NN cord-018907-c84t1bo5 52 6 should should MD cord-018907-c84t1bo5 52 7 include include VB cord-018907-c84t1bo5 52 8 agents agent NNS cord-018907-c84t1bo5 52 9 active active JJ cord-018907-c84t1bo5 52 10 against against IN cord-018907-c84t1bo5 52 11 Gram gram NN cord-018907-c84t1bo5 52 12 - - HYPH cord-018907-c84t1bo5 52 13 negative negative JJ cord-018907-c84t1bo5 52 14 pathogen pathogen NN cord-018907-c84t1bo5 52 15 plus plus CC cord-018907-c84t1bo5 52 16 anti anti JJ cord-018907-c84t1bo5 52 17 - - JJ cord-018907-c84t1bo5 52 18 staphylococcus staphylococcus JJ cord-018907-c84t1bo5 52 19 agents agent NNS cord-018907-c84t1bo5 52 20 , , , cord-018907-c84t1bo5 52 21 for for IN cord-018907-c84t1bo5 52 22 example example NN cord-018907-c84t1bo5 52 23 , , , cord-018907-c84t1bo5 52 24 cefotaxime cefotaxime NN cord-018907-c84t1bo5 52 25 or or CC cord-018907-c84t1bo5 52 26 ceftriaxone ceftriaxone NNP cord-018907-c84t1bo5 52 27 plus plus CC cord-018907-c84t1bo5 52 28 naficillin naficillin NNP cord-018907-c84t1bo5 52 29 ; ; : cord-018907-c84t1bo5 52 30 if if IN cord-018907-c84t1bo5 52 31 MRSA MRSA NNP cord-018907-c84t1bo5 52 32 or or CC cord-018907-c84t1bo5 52 33 penicillin penicillin NN cord-018907-c84t1bo5 52 34 resistant resistant JJ cord-018907-c84t1bo5 52 35 S. S. NNP cord-018907-c84t1bo5 52 36 pneumonia pneumonia NN cord-018907-c84t1bo5 52 37 is be VBZ cord-018907-c84t1bo5 52 38 suspected suspect VBN cord-018907-c84t1bo5 52 39 , , , cord-018907-c84t1bo5 52 40 one one PRP cord-018907-c84t1bo5 52 41 can can MD cord-018907-c84t1bo5 52 42 use use VB cord-018907-c84t1bo5 52 43 vancomycin vancomycin NN cord-018907-c84t1bo5 52 44 . . . cord-018907-c84t1bo5 53 1 The the DT cord-018907-c84t1bo5 53 2 pathogen pathogen NN cord-018907-c84t1bo5 53 3 in in IN cord-018907-c84t1bo5 53 4 immunocompromised immunocompromised JJ cord-018907-c84t1bo5 53 5 patients patient NNS cord-018907-c84t1bo5 53 6 can can MD cord-018907-c84t1bo5 53 7 be be VB cord-018907-c84t1bo5 53 8 predicted predict VBN cord-018907-c84t1bo5 53 9 by by IN cord-018907-c84t1bo5 53 10 the the DT cord-018907-c84t1bo5 53 11 system system NN cord-018907-c84t1bo5 53 12 involved involve VBN cord-018907-c84t1bo5 53 13 during during IN cord-018907-c84t1bo5 53 14 the the DT cord-018907-c84t1bo5 53 15 presentation presentation NN cord-018907-c84t1bo5 53 16 . . . cord-018907-c84t1bo5 54 1 For for IN cord-018907-c84t1bo5 54 2 example example NN cord-018907-c84t1bo5 54 3 , , , cord-018907-c84t1bo5 54 4 the the DT cord-018907-c84t1bo5 54 5 presentation presentation NN cord-018907-c84t1bo5 54 6 and and CC cord-018907-c84t1bo5 54 7 etiological etiological JJ cord-018907-c84t1bo5 54 8 agents agent NNS cord-018907-c84t1bo5 54 9 in in IN cord-018907-c84t1bo5 54 10 pneumonia pneumonia NN cord-018907-c84t1bo5 54 11 in in IN cord-018907-c84t1bo5 54 12 immunocompromised immunocompromised JJ cord-018907-c84t1bo5 54 13 patients patient NNS cord-018907-c84t1bo5 54 14 are be VBP cord-018907-c84t1bo5 54 15 different different JJ cord-018907-c84t1bo5 54 16 than than IN cord-018907-c84t1bo5 54 17 immunocompetent immunocompetent JJ cord-018907-c84t1bo5 54 18 persons person NNS cord-018907-c84t1bo5 54 19 . . . cord-018907-c84t1bo5 55 1 In in IN cord-018907-c84t1bo5 55 2 evaluating evaluate VBG cord-018907-c84t1bo5 55 3 pneumonia pneumonia NN cord-018907-c84t1bo5 55 4 in in IN cord-018907-c84t1bo5 55 5 immunocompromised immunocompromised JJ cord-018907-c84t1bo5 55 6 patients patient NNS cord-018907-c84t1bo5 55 7 , , , cord-018907-c84t1bo5 55 8 one one PRP cord-018907-c84t1bo5 55 9 needs need VBZ cord-018907-c84t1bo5 55 10 to to TO cord-018907-c84t1bo5 55 11 know know VB cord-018907-c84t1bo5 55 12 that that IN cord-018907-c84t1bo5 55 13 the the DT cord-018907-c84t1bo5 55 14 pulmonary pulmonary JJ cord-018907-c84t1bo5 55 15 complication complication NN cord-018907-c84t1bo5 55 16 is be VBZ cord-018907-c84t1bo5 55 17 present present JJ cord-018907-c84t1bo5 55 18 in in IN cord-018907-c84t1bo5 56 1 up up IN cord-018907-c84t1bo5 56 2 to to TO cord-018907-c84t1bo5 56 3 60 60 CD cord-018907-c84t1bo5 56 4 % % NN cord-018907-c84t1bo5 56 5 of of IN cord-018907-c84t1bo5 56 6 immunocompromised immunocompromised JJ cord-018907-c84t1bo5 56 7 patients patient NNS cord-018907-c84t1bo5 56 8 and and CC cord-018907-c84t1bo5 56 9 mortality mortality NN cord-018907-c84t1bo5 56 10 is be VBZ cord-018907-c84t1bo5 56 11 up up IN cord-018907-c84t1bo5 56 12 to to TO cord-018907-c84t1bo5 56 13 80 80 CD cord-018907-c84t1bo5 56 14 % % NN cord-018907-c84t1bo5 56 15 of of IN cord-018907-c84t1bo5 56 16 those those DT cord-018907-c84t1bo5 56 17 who who WP cord-018907-c84t1bo5 56 18 require require VBP cord-018907-c84t1bo5 56 19 mechanical mechanical JJ cord-018907-c84t1bo5 56 20 ventilation ventilation NN cord-018907-c84t1bo5 56 21 . . . cord-018907-c84t1bo5 57 1 The the DT cord-018907-c84t1bo5 57 2 initial initial JJ cord-018907-c84t1bo5 57 3 evaluation evaluation NN cord-018907-c84t1bo5 57 4 needs need VBZ cord-018907-c84t1bo5 57 5 rapid rapid JJ cord-018907-c84t1bo5 57 6 assessment assessment NN cord-018907-c84t1bo5 57 7 of of IN cord-018907-c84t1bo5 57 8 the the DT cord-018907-c84t1bo5 57 9 vital vital JJ cord-018907-c84t1bo5 57 10 signs sign NNS cord-018907-c84t1bo5 57 11 including include VBG cord-018907-c84t1bo5 57 12 oxygen oxygen NN cord-018907-c84t1bo5 57 13 saturation saturation NN cord-018907-c84t1bo5 57 14 , , , cord-018907-c84t1bo5 57 15 complete complete JJ cord-018907-c84t1bo5 57 16 blood blood NN cord-018907-c84t1bo5 57 17 count count NN cord-018907-c84t1bo5 57 18 with with IN cord-018907-c84t1bo5 57 19 differential differential JJ cord-018907-c84t1bo5 57 20 , , , cord-018907-c84t1bo5 57 21 renal renal JJ cord-018907-c84t1bo5 57 22 profile profile NN cord-018907-c84t1bo5 57 23 , , , cord-018907-c84t1bo5 57 24 blood blood NN cord-018907-c84t1bo5 57 25 culture culture NN cord-018907-c84t1bo5 57 26 , , , cord-018907-c84t1bo5 57 27 and and CC cord-018907-c84t1bo5 57 28 imaging imaging NN cord-018907-c84t1bo5 57 29 of of IN cord-018907-c84t1bo5 57 30 the the DT cord-018907-c84t1bo5 57 31 lung lung NN cord-018907-c84t1bo5 57 32 either either CC cord-018907-c84t1bo5 57 33 chest chest NN cord-018907-c84t1bo5 57 34 X x NN cord-018907-c84t1bo5 57 35 - - NN cord-018907-c84t1bo5 57 36 ray ray NN cord-018907-c84t1bo5 57 37 or or CC cord-018907-c84t1bo5 57 38 CT CT NNP cord-018907-c84t1bo5 57 39 scan scan NN cord-018907-c84t1bo5 57 40 . . . cord-018907-c84t1bo5 58 1 The the DT cord-018907-c84t1bo5 58 2 organism organism NN cord-018907-c84t1bo5 58 3 can can MD cord-018907-c84t1bo5 58 4 be be VB cord-018907-c84t1bo5 58 5 predicted predict VBN cord-018907-c84t1bo5 58 6 based base VBN cord-018907-c84t1bo5 58 7 on on IN cord-018907-c84t1bo5 58 8 the the DT cord-018907-c84t1bo5 58 9 primary primary JJ cord-018907-c84t1bo5 58 10 immune immune JJ cord-018907-c84t1bo5 58 11 defect defect NN cord-018907-c84t1bo5 58 12 . . . cord-018907-c84t1bo5 59 1 At at IN cord-018907-c84t1bo5 59 2 certain certain JJ cord-018907-c84t1bo5 59 3 point point NN cord-018907-c84t1bo5 59 4 in in IN cord-018907-c84t1bo5 59 5 the the DT cord-018907-c84t1bo5 59 6 history history NN cord-018907-c84t1bo5 59 7 , , , cord-018907-c84t1bo5 59 8 the the DT cord-018907-c84t1bo5 59 9 defect defect NN cord-018907-c84t1bo5 59 10 in in IN cord-018907-c84t1bo5 59 11 the the DT cord-018907-c84t1bo5 59 12 immune immune JJ cord-018907-c84t1bo5 59 13 system system NN cord-018907-c84t1bo5 59 14 , , , cord-018907-c84t1bo5 59 15 the the DT cord-018907-c84t1bo5 59 16 presence presence NN cord-018907-c84t1bo5 59 17 or or CC cord-018907-c84t1bo5 59 18 absence absence NN cord-018907-c84t1bo5 59 19 of of IN cord-018907-c84t1bo5 59 20 neutropenia neutropenia NN cord-018907-c84t1bo5 59 21 , , , cord-018907-c84t1bo5 59 22 history history NN cord-018907-c84t1bo5 59 23 of of IN cord-018907-c84t1bo5 59 24 antimicrobial antimicrobial JJ cord-018907-c84t1bo5 59 25 exposure exposure NN cord-018907-c84t1bo5 59 26 , , , cord-018907-c84t1bo5 59 27 the the DT cord-018907-c84t1bo5 59 28 presence presence NN cord-018907-c84t1bo5 59 29 of of IN cord-018907-c84t1bo5 59 30 potential potential JJ cord-018907-c84t1bo5 59 31 pulmonary pulmonary JJ cord-018907-c84t1bo5 59 32 pathogens pathogen NNS cord-018907-c84t1bo5 59 33 in in IN cord-018907-c84t1bo5 59 34 previous previous JJ cord-018907-c84t1bo5 59 35 cultures culture NNS cord-018907-c84t1bo5 59 36 , , , cord-018907-c84t1bo5 59 37 and and CC cord-018907-c84t1bo5 59 38 the the DT cord-018907-c84t1bo5 59 39 presence presence NN cord-018907-c84t1bo5 59 40 of of IN cord-018907-c84t1bo5 59 41 indwelling indwell VBG cord-018907-c84t1bo5 59 42 catheters catheter NNS cord-018907-c84t1bo5 59 43 should should MD cord-018907-c84t1bo5 59 44 be be VB cord-018907-c84t1bo5 59 45 looked look VBN cord-018907-c84t1bo5 59 46 at at IN cord-018907-c84t1bo5 59 47 . . . cord-018907-c84t1bo5 60 1 The the DT cord-018907-c84t1bo5 60 2 pattern pattern NN cord-018907-c84t1bo5 60 3 and and CC cord-018907-c84t1bo5 60 4 distribution distribution NN cord-018907-c84t1bo5 60 5 of of IN cord-018907-c84t1bo5 60 6 radiological radiological JJ cord-018907-c84t1bo5 60 7 abnormalities abnormality NNS cord-018907-c84t1bo5 60 8 can can MD cord-018907-c84t1bo5 60 9 predict predict VB cord-018907-c84t1bo5 60 10 the the DT cord-018907-c84t1bo5 60 11 pathogen pathogen NN cord-018907-c84t1bo5 60 12 and and CC cord-018907-c84t1bo5 60 13 the the DT cord-018907-c84t1bo5 60 14 time time NN cord-018907-c84t1bo5 60 15 and and CC cord-018907-c84t1bo5 60 16 the the DT cord-018907-c84t1bo5 60 17 rate rate NN cord-018907-c84t1bo5 60 18 of of IN cord-018907-c84t1bo5 60 19 progression progression NN cord-018907-c84t1bo5 60 20 and and CC cord-018907-c84t1bo5 60 21 time time NN cord-018907-c84t1bo5 60 22 to to IN cord-018907-c84t1bo5 60 23 resolution resolution NN cord-018907-c84t1bo5 60 24 of of IN cord-018907-c84t1bo5 60 25 pulmonary pulmonary JJ cord-018907-c84t1bo5 60 26 abnormalities abnormality NNS cord-018907-c84t1bo5 60 27 . . . cord-018907-c84t1bo5 61 1 For for IN cord-018907-c84t1bo5 61 2 definitive definitive JJ cord-018907-c84t1bo5 61 3 diagnoses diagnosis NNS cord-018907-c84t1bo5 61 4 invasive invasive JJ cord-018907-c84t1bo5 61 5 procedures procedure NNS cord-018907-c84t1bo5 61 6 may may MD cord-018907-c84t1bo5 61 7 be be VB cord-018907-c84t1bo5 61 8 needed need VBN cord-018907-c84t1bo5 61 9 including include VBG cord-018907-c84t1bo5 61 10 bronchoalveolar bronchoalveolar NNP cord-018907-c84t1bo5 61 11 lavage lavage NNP cord-018907-c84t1bo5 61 12 ( ( -LRB- cord-018907-c84t1bo5 61 13 BAL BAL NNP cord-018907-c84t1bo5 61 14 ) ) -RRB- cord-018907-c84t1bo5 61 15 , , , cord-018907-c84t1bo5 61 16 transbronchial transbronchial NNP cord-018907-c84t1bo5 61 17 biopsy biopsy NN cord-018907-c84t1bo5 61 18 , , , cord-018907-c84t1bo5 61 19 needless needless JJ cord-018907-c84t1bo5 61 20 biopsy biopsy NN cord-018907-c84t1bo5 61 21 , , , cord-018907-c84t1bo5 61 22 thorascopic thorascopic NNP cord-018907-c84t1bo5 61 23 biopsy biopsy NNP cord-018907-c84t1bo5 61 24 , , , cord-018907-c84t1bo5 61 25 and and CC cord-018907-c84t1bo5 61 26 open open JJ cord-018907-c84t1bo5 61 27 lung lung NN cord-018907-c84t1bo5 61 28 biopsy biopsy NN cord-018907-c84t1bo5 61 29 . . . cord-018907-c84t1bo5 62 1 In in IN cord-018907-c84t1bo5 62 2 obtaining obtain VBG cord-018907-c84t1bo5 62 3 the the DT cord-018907-c84t1bo5 62 4 biopsy biopsy NN cord-018907-c84t1bo5 62 5 from from IN cord-018907-c84t1bo5 62 6 this this DT cord-018907-c84t1bo5 62 7 patient patient NN cord-018907-c84t1bo5 62 8 , , , cord-018907-c84t1bo5 62 9 it -PRON- PRP cord-018907-c84t1bo5 62 10 is be VBZ cord-018907-c84t1bo5 62 11 very very RB cord-018907-c84t1bo5 62 12 important important JJ cord-018907-c84t1bo5 62 13 to to TO cord-018907-c84t1bo5 62 14 send send VB cord-018907-c84t1bo5 62 15 it -PRON- PRP cord-018907-c84t1bo5 62 16 for for IN cord-018907-c84t1bo5 62 17 histopathology histopathology NN cord-018907-c84t1bo5 62 18 for for IN cord-018907-c84t1bo5 62 19 special special JJ cord-018907-c84t1bo5 62 20 staining staining NN cord-018907-c84t1bo5 62 21 , , , cord-018907-c84t1bo5 62 22 for for IN cord-018907-c84t1bo5 62 23 viruses virus NNS cord-018907-c84t1bo5 62 24 , , , cord-018907-c84t1bo5 62 25 bacteria bacteria NNS cord-018907-c84t1bo5 62 26 , , , cord-018907-c84t1bo5 62 27 fungi fungus NNS cord-018907-c84t1bo5 62 28 , , , cord-018907-c84t1bo5 62 29 pneumocystis pneumocystis NN cord-018907-c84t1bo5 62 30 , , , cord-018907-c84t1bo5 62 31 mycobacterial mycobacterial JJ cord-018907-c84t1bo5 62 32 pathogen pathogen NN cord-018907-c84t1bo5 62 33 , , , cord-018907-c84t1bo5 62 34 and and CC cord-018907-c84t1bo5 62 35 also also RB cord-018907-c84t1bo5 62 36 culture culture NN cord-018907-c84t1bo5 62 37 for for IN cord-018907-c84t1bo5 62 38 viral viral JJ cord-018907-c84t1bo5 62 39 , , , cord-018907-c84t1bo5 62 40 fungal fungal JJ cord-018907-c84t1bo5 62 41 , , , cord-018907-c84t1bo5 62 42 bacterial bacterial JJ cord-018907-c84t1bo5 62 43 , , , cord-018907-c84t1bo5 62 44 and and CC cord-018907-c84t1bo5 62 45 mycobacterium mycobacterium NN cord-018907-c84t1bo5 62 46 . . . cord-018907-c84t1bo5 63 1 Other other JJ cord-018907-c84t1bo5 63 2 laboratory laboratory NN cord-018907-c84t1bo5 63 3 tests test NNS cord-018907-c84t1bo5 63 4 that that WDT cord-018907-c84t1bo5 63 5 will will MD cord-018907-c84t1bo5 63 6 help help VB cord-018907-c84t1bo5 63 7 in in IN cord-018907-c84t1bo5 63 8 diagnosing diagnose VBG cord-018907-c84t1bo5 63 9 pneumonia pneumonia NN cord-018907-c84t1bo5 63 10 are be VBP cord-018907-c84t1bo5 63 11 nasal nasal NN cord-018907-c84t1bo5 63 12 washings washing NNS cord-018907-c84t1bo5 63 13 or or CC cord-018907-c84t1bo5 63 14 swabs swab NNS cord-018907-c84t1bo5 63 15 for for IN cord-018907-c84t1bo5 63 16 direct direct JJ cord-018907-c84t1bo5 63 17 fluorescent fluorescent JJ cord-018907-c84t1bo5 63 18 antibody antibody NN cord-018907-c84t1bo5 63 19 , , , cord-018907-c84t1bo5 63 20 PCR PCR NNP cord-018907-c84t1bo5 63 21 for for IN cord-018907-c84t1bo5 63 22 respiratory respiratory JJ cord-018907-c84t1bo5 63 23 viruses virus NNS cord-018907-c84t1bo5 63 24 and and CC cord-018907-c84t1bo5 63 25 atypical atypical JJ cord-018907-c84t1bo5 63 26 pneumonia pneumonia NN cord-018907-c84t1bo5 63 27 , , , cord-018907-c84t1bo5 63 28 culture culture NN cord-018907-c84t1bo5 63 29 and and CC cord-018907-c84t1bo5 63 30 staining staining NN cord-018907-c84t1bo5 63 31 , , , cord-018907-c84t1bo5 63 32 CMV CMV NNP cord-018907-c84t1bo5 63 33 antigenemia antigenemia NN cord-018907-c84t1bo5 63 34 or or CC cord-018907-c84t1bo5 63 35 CMV CMV NNP cord-018907-c84t1bo5 63 36 viral viral JJ cord-018907-c84t1bo5 63 37 load load NN cord-018907-c84t1bo5 63 38 testing testing NN cord-018907-c84t1bo5 63 39 , , , cord-018907-c84t1bo5 63 40 Aspergillus Aspergillus NNP cord-018907-c84t1bo5 63 41 galactomannan galactomannan NNP cord-018907-c84t1bo5 63 42 assay assay NN cord-018907-c84t1bo5 63 43 , , , cord-018907-c84t1bo5 63 44 and and CC cord-018907-c84t1bo5 63 45 1,3 1,3 CD cord-018907-c84t1bo5 63 46 beta beta NN cord-018907-c84t1bo5 63 47 D d NN cord-018907-c84t1bo5 63 48 glucan glucan NN cord-018907-c84t1bo5 63 49 . . . cord-018907-c84t1bo5 64 1 The the DT cord-018907-c84t1bo5 64 2 radiological radiological JJ cord-018907-c84t1bo5 64 3 finding finding NN cord-018907-c84t1bo5 64 4 in in IN cord-018907-c84t1bo5 64 5 immunocompromised immunocompromised JJ cord-018907-c84t1bo5 64 6 patient patient NN cord-018907-c84t1bo5 64 7 can can MD cord-018907-c84t1bo5 64 8 be be VB cord-018907-c84t1bo5 64 9 focal focal JJ cord-018907-c84t1bo5 64 10 ( ( -LRB- cord-018907-c84t1bo5 64 11 lobar lobar JJ cord-018907-c84t1bo5 64 12 or or CC cord-018907-c84t1bo5 64 13 segmental segmental JJ cord-018907-c84t1bo5 64 14 infiltrate infiltrate NN cord-018907-c84t1bo5 64 15 ) ) -RRB- cord-018907-c84t1bo5 64 16 , , , cord-018907-c84t1bo5 64 17 diffuse diffuse VB cord-018907-c84t1bo5 64 18 interstitial interstitial JJ cord-018907-c84t1bo5 64 19 infiltrate infiltrate NN cord-018907-c84t1bo5 64 20 or or CC cord-018907-c84t1bo5 64 21 nodular nodular JJ cord-018907-c84t1bo5 64 22 ( ( -LRB- cord-018907-c84t1bo5 64 23 with with IN cord-018907-c84t1bo5 64 24 or or CC cord-018907-c84t1bo5 64 25 without without IN cord-018907-c84t1bo5 64 26 cavitation cavitation NN cord-018907-c84t1bo5 64 27 ) ) -RRB- cord-018907-c84t1bo5 64 28 . . . cord-018907-c84t1bo5 65 1 Focal focal JJ cord-018907-c84t1bo5 65 2 infiltrate infiltrate NN cord-018907-c84t1bo5 65 3 can can MD cord-018907-c84t1bo5 65 4 be be VB cord-018907-c84t1bo5 65 5 due due JJ cord-018907-c84t1bo5 65 6 to to IN cord-018907-c84t1bo5 65 7 Gram gram NN cord-018907-c84t1bo5 65 8 - - HYPH cord-018907-c84t1bo5 65 9 positive positive JJ cord-018907-c84t1bo5 65 10 or or CC cord-018907-c84t1bo5 65 11 Gram gram NN cord-018907-c84t1bo5 65 12 - - HYPH cord-018907-c84t1bo5 65 13 negative negative JJ cord-018907-c84t1bo5 65 14 bacteria bacteria NNS cord-018907-c84t1bo5 65 15 , , , cord-018907-c84t1bo5 65 16 Legionella Legionella NNP cord-018907-c84t1bo5 65 17 , , , cord-018907-c84t1bo5 65 18 mycobacteria mycobacterium NNS cord-018907-c84t1bo5 65 19 , , , cord-018907-c84t1bo5 65 20 and and CC cord-018907-c84t1bo5 65 21 fungal fungal JJ cord-018907-c84t1bo5 65 22 infection infection NN cord-018907-c84t1bo5 65 23 . . . cord-018907-c84t1bo5 66 1 Also also RB cord-018907-c84t1bo5 66 2 the the DT cord-018907-c84t1bo5 66 3 noninfectious noninfectious JJ cord-018907-c84t1bo5 66 4 etiology etiology NN cord-018907-c84t1bo5 66 5 includes include VBZ cord-018907-c84t1bo5 66 6 infarction infarction NN cord-018907-c84t1bo5 66 7 , , , cord-018907-c84t1bo5 66 8 radiation radiation NN cord-018907-c84t1bo5 66 9 , , , cord-018907-c84t1bo5 66 10 and and CC cord-018907-c84t1bo5 66 11 drug drug NN cord-018907-c84t1bo5 66 12 - - HYPH cord-018907-c84t1bo5 66 13 related relate VBN cord-018907-c84t1bo5 66 14 bronchiolitis bronchiolitis NN cord-018907-c84t1bo5 66 15 obliterans obliteran NNS cord-018907-c84t1bo5 66 16 organizing organize VBG cord-018907-c84t1bo5 66 17 pneumonia pneumonia NN cord-018907-c84t1bo5 66 18 ( ( -LRB- cord-018907-c84t1bo5 66 19 BOOP BOOP NNP cord-018907-c84t1bo5 66 20 ) ) -RRB- cord-018907-c84t1bo5 66 21 . . . cord-018907-c84t1bo5 67 1 Diffuse diffuse JJ cord-018907-c84t1bo5 67 2 interstitial interstitial JJ cord-018907-c84t1bo5 67 3 infiltrate infiltrate NN cord-018907-c84t1bo5 67 4 is be VBZ cord-018907-c84t1bo5 67 5 caused cause VBN cord-018907-c84t1bo5 67 6 by by IN cord-018907-c84t1bo5 67 7 viral viral JJ cord-018907-c84t1bo5 67 8 infection infection NN cord-018907-c84t1bo5 67 9 , , , cord-018907-c84t1bo5 67 10 Pneumocystis Pneumocystis NNP cord-018907-c84t1bo5 67 11 jiroveci jiroveci NNS cord-018907-c84t1bo5 67 12 , , , cord-018907-c84t1bo5 67 13 less less RBR cord-018907-c84t1bo5 67 14 likely likely JJ cord-018907-c84t1bo5 67 15 mycobacterium mycobacterium NN cord-018907-c84t1bo5 67 16 , , , cord-018907-c84t1bo5 67 17 disseminated disseminate VBN cord-018907-c84t1bo5 67 18 fungal fungal JJ cord-018907-c84t1bo5 67 19 infection infection NN cord-018907-c84t1bo5 67 20 , , , cord-018907-c84t1bo5 67 21 atypical atypical JJ cord-018907-c84t1bo5 67 22 pneumonium pneumonium NN cord-018907-c84t1bo5 67 23 including include VBG cord-018907-c84t1bo5 67 24 Chlamydia Chlamydia NNP cord-018907-c84t1bo5 67 25 , , , cord-018907-c84t1bo5 67 26 Legionella Legionella NNP cord-018907-c84t1bo5 67 27 , , , cord-018907-c84t1bo5 67 28 and and CC cord-018907-c84t1bo5 67 29 mycoplasma mycoplasma NN cord-018907-c84t1bo5 67 30 . . . cord-018907-c84t1bo5 68 1 Other other JJ cord-018907-c84t1bo5 68 2 noninfectious noninfectious JJ cord-018907-c84t1bo5 68 3 etiology etiology NN cord-018907-c84t1bo5 68 4 causing cause VBG cord-018907-c84t1bo5 68 5 diffuse diffuse JJ cord-018907-c84t1bo5 68 6 interstitial interstitial JJ cord-018907-c84t1bo5 68 7 infiltrate infiltrate NN cord-018907-c84t1bo5 68 8 include include VBP cord-018907-c84t1bo5 68 9 edema edema NN cord-018907-c84t1bo5 68 10 , , , cord-018907-c84t1bo5 68 11 acute acute JJ cord-018907-c84t1bo5 68 12 respiratory respiratory JJ cord-018907-c84t1bo5 68 13 distress distress NN cord-018907-c84t1bo5 68 14 syndrome syndrome NN cord-018907-c84t1bo5 68 15 ( ( -LRB- cord-018907-c84t1bo5 68 16 ARDS ARDS NNP cord-018907-c84t1bo5 68 17 ) ) -RRB- cord-018907-c84t1bo5 68 18 , , , cord-018907-c84t1bo5 68 19 and and CC cord-018907-c84t1bo5 68 20 drug drug NN cord-018907-c84t1bo5 68 21 - - HYPH cord-018907-c84t1bo5 68 22 related relate VBN cord-018907-c84t1bo5 68 23 radiation radiation NN cord-018907-c84t1bo5 68 24 . . . cord-018907-c84t1bo5 69 1 For for IN cord-018907-c84t1bo5 69 2 nodular nodular JJ cord-018907-c84t1bo5 69 3 infiltrate infiltrate NN cord-018907-c84t1bo5 69 4 with with IN cord-018907-c84t1bo5 69 5 or or CC cord-018907-c84t1bo5 69 6 without without IN cord-018907-c84t1bo5 69 7 cavitation cavitation NN cord-018907-c84t1bo5 69 8 the the DT cord-018907-c84t1bo5 69 9 infectious infectious JJ cord-018907-c84t1bo5 69 10 etiology etiology NN cord-018907-c84t1bo5 69 11 include include VBP cord-018907-c84t1bo5 69 12 Aspergillus aspergillus NN cord-018907-c84t1bo5 69 13 infection infection NN cord-018907-c84t1bo5 69 14 , , , cord-018907-c84t1bo5 69 15 and and CC cord-018907-c84t1bo5 69 16 other other JJ cord-018907-c84t1bo5 69 17 mycoses mycose NNS cord-018907-c84t1bo5 69 18 , , , cord-018907-c84t1bo5 69 19 Nocardia Nocardia NNP cord-018907-c84t1bo5 69 20 , , , cord-018907-c84t1bo5 69 21 bacteria bacteria NNS cord-018907-c84t1bo5 69 22 either either CC cord-018907-c84t1bo5 69 23 Gram gram NN cord-018907-c84t1bo5 69 24 - - HYPH cord-018907-c84t1bo5 69 25 positive positive JJ cord-018907-c84t1bo5 69 26 or or CC cord-018907-c84t1bo5 69 27 Gram gram NN cord-018907-c84t1bo5 69 28 - - HYPH cord-018907-c84t1bo5 69 29 negative negative JJ cord-018907-c84t1bo5 69 30 , , , cord-018907-c84t1bo5 69 31 anaerobes anaerobe NNS cord-018907-c84t1bo5 69 32 , , , cord-018907-c84t1bo5 69 33 and and CC cord-018907-c84t1bo5 69 34 Mycobacterium Mycobacterium NNP cord-018907-c84t1bo5 69 35 TB TB NNP cord-018907-c84t1bo5 69 36 , , , cord-018907-c84t1bo5 69 37 as as RB cord-018907-c84t1bo5 69 38 well well RB cord-018907-c84t1bo5 69 39 as as IN cord-018907-c84t1bo5 69 40 noninfectious noninfectious JJ cord-018907-c84t1bo5 69 41 etiology etiology NN cord-018907-c84t1bo5 69 42 including include VBG cord-018907-c84t1bo5 69 43 disease disease NN cord-018907-c84t1bo5 69 44 progression progression NN cord-018907-c84t1bo5 69 45 like like IN cord-018907-c84t1bo5 69 46 metastasis metastasis NN cord-018907-c84t1bo5 69 47 and and CC cord-018907-c84t1bo5 69 48 drug drug NN cord-018907-c84t1bo5 69 49 toxicity toxicity NN cord-018907-c84t1bo5 69 50 . . . cord-018907-c84t1bo5 70 1 The the DT cord-018907-c84t1bo5 70 2 management management NN cord-018907-c84t1bo5 70 3 of of IN cord-018907-c84t1bo5 70 4 immunocompromised immunocompromised JJ cord-018907-c84t1bo5 70 5 patients patient NNS cord-018907-c84t1bo5 70 6 with with IN cord-018907-c84t1bo5 70 7 pulmonary pulmonary JJ cord-018907-c84t1bo5 70 8 infiltrate infiltrate NN cord-018907-c84t1bo5 70 9 will will MD cord-018907-c84t1bo5 70 10 depend depend VB cord-018907-c84t1bo5 70 11 on on IN cord-018907-c84t1bo5 70 12 the the DT cord-018907-c84t1bo5 70 13 patient patient JJ cord-018907-c84t1bo5 70 14 presentation presentation NN cord-018907-c84t1bo5 70 15 . . . cord-018907-c84t1bo5 71 1 If if IN cord-018907-c84t1bo5 71 2 the the DT cord-018907-c84t1bo5 71 3 patient patient NN cord-018907-c84t1bo5 71 4 is be VBZ cord-018907-c84t1bo5 71 5 acutely acutely RB cord-018907-c84t1bo5 71 6 ill ill JJ cord-018907-c84t1bo5 71 7 , , , cord-018907-c84t1bo5 71 8 it -PRON- PRP cord-018907-c84t1bo5 71 9 is be VBZ cord-018907-c84t1bo5 71 10 very very RB cord-018907-c84t1bo5 71 11 important important JJ cord-018907-c84t1bo5 71 12 to to TO cord-018907-c84t1bo5 71 13 begin begin VB cord-018907-c84t1bo5 71 14 empiric empiric JJ cord-018907-c84t1bo5 71 15 therapy therapy NN cord-018907-c84t1bo5 71 16 to to TO cord-018907-c84t1bo5 71 17 cover cover VB cord-018907-c84t1bo5 71 18 the the DT cord-018907-c84t1bo5 71 19 likely likely JJ cord-018907-c84t1bo5 71 20 pathogen pathogen NN cord-018907-c84t1bo5 71 21 based base VBN cord-018907-c84t1bo5 71 22 on on IN cord-018907-c84t1bo5 71 23 the the DT cord-018907-c84t1bo5 71 24 presentation presentation NN cord-018907-c84t1bo5 71 25 of of IN cord-018907-c84t1bo5 71 26 the the DT cord-018907-c84t1bo5 71 27 patient patient NN cord-018907-c84t1bo5 71 28 and and CC cord-018907-c84t1bo5 71 29 the the DT cord-018907-c84t1bo5 71 30 primary primary JJ cord-018907-c84t1bo5 71 31 immune immune JJ cord-018907-c84t1bo5 71 32 defect defect NN cord-018907-c84t1bo5 71 33 with with IN cord-018907-c84t1bo5 71 34 simultaneously simultaneously RB cord-018907-c84t1bo5 71 35 comprehensive comprehensive JJ cord-018907-c84t1bo5 71 36 evaluation evaluation NN cord-018907-c84t1bo5 71 37 . . . cord-018907-c84t1bo5 72 1 Subsequently subsequently RB cord-018907-c84t1bo5 72 2 , , , cord-018907-c84t1bo5 72 3 therapy therapy NN cord-018907-c84t1bo5 72 4 should should MD cord-018907-c84t1bo5 72 5 be be VB cord-018907-c84t1bo5 72 6 adjusted adjust VBN cord-018907-c84t1bo5 72 7 based base VBN cord-018907-c84t1bo5 72 8 on on IN cord-018907-c84t1bo5 72 9 culture culture NN cord-018907-c84t1bo5 72 10 and and CC cord-018907-c84t1bo5 72 11 clinical clinical JJ cord-018907-c84t1bo5 72 12 response response NN cord-018907-c84t1bo5 72 13 . . . cord-018907-c84t1bo5 73 1 In in IN cord-018907-c84t1bo5 73 2 providing provide VBG cord-018907-c84t1bo5 73 3 empirical empirical JJ cord-018907-c84t1bo5 73 4 antibiotic antibiotic JJ cord-018907-c84t1bo5 73 5 therapy therapy NN cord-018907-c84t1bo5 73 6 in in IN cord-018907-c84t1bo5 73 7 patient patient NN cord-018907-c84t1bo5 73 8 with with IN cord-018907-c84t1bo5 73 9 pulmonary pulmonary JJ cord-018907-c84t1bo5 73 10 infiltrate infiltrate NN cord-018907-c84t1bo5 73 11 and and CC cord-018907-c84t1bo5 73 12 defect defect VB cord-018907-c84t1bo5 73 13 in in IN cord-018907-c84t1bo5 73 14 cell cell NN cord-018907-c84t1bo5 73 15 - - HYPH cord-018907-c84t1bo5 73 16 mediated mediate VBN cord-018907-c84t1bo5 73 17 immunity immunity NN cord-018907-c84t1bo5 73 18 one one CD cord-018907-c84t1bo5 73 19 need need NN cord-018907-c84t1bo5 73 20 to to TO cord-018907-c84t1bo5 73 21 consider consider VB cord-018907-c84t1bo5 73 22 Pneumocystis Pneumocystis NNP cord-018907-c84t1bo5 73 23 jiroveci jiroveci NNS cord-018907-c84t1bo5 73 24 , , , cord-018907-c84t1bo5 73 25 nocardia nocardia NNP cord-018907-c84t1bo5 73 26 , , , cord-018907-c84t1bo5 73 27 legionella legionella NN cord-018907-c84t1bo5 73 28 , , , cord-018907-c84t1bo5 73 29 mycoplasma mycoplasma NN cord-018907-c84t1bo5 73 30 , , , cord-018907-c84t1bo5 73 31 in in IN cord-018907-c84t1bo5 73 32 addition addition NN cord-018907-c84t1bo5 73 33 to to IN cord-018907-c84t1bo5 73 34 aerobic aerobic JJ cord-018907-c84t1bo5 73 35 Gram gram NN cord-018907-c84t1bo5 73 36 - - HYPH cord-018907-c84t1bo5 73 37 positive positive JJ cord-018907-c84t1bo5 73 38 cocci coccus NNS cord-018907-c84t1bo5 73 39 and and CC cord-018907-c84t1bo5 73 40 Gram gram NN cord-018907-c84t1bo5 73 41 - - HYPH cord-018907-c84t1bo5 73 42 negative negative JJ cord-018907-c84t1bo5 73 43 bacilli bacilli NN cord-018907-c84t1bo5 73 44 therefore therefore RB cord-018907-c84t1bo5 73 45 it -PRON- PRP cord-018907-c84t1bo5 73 46 is be VBZ cord-018907-c84t1bo5 73 47 advised advise VBN cord-018907-c84t1bo5 73 48 to to TO cord-018907-c84t1bo5 73 49 use use VB cord-018907-c84t1bo5 73 50 trimethoprim trimethoprim NNP cord-018907-c84t1bo5 73 51 - - HYPH cord-018907-c84t1bo5 73 52 sulfamethoxazole sulfamethoxazole NNP cord-018907-c84t1bo5 73 53 , , , cord-018907-c84t1bo5 73 54 macrolides macrolide NNS cord-018907-c84t1bo5 73 55 including include VBG cord-018907-c84t1bo5 73 56 erythromycin erythromycin NNS cord-018907-c84t1bo5 73 57 or or CC cord-018907-c84t1bo5 73 58 clarithromycin clarithromycin NNS cord-018907-c84t1bo5 73 59 and and CC cord-018907-c84t1bo5 73 60 agent agent NN cord-018907-c84t1bo5 73 61 active active JJ cord-018907-c84t1bo5 73 62 against against IN cord-018907-c84t1bo5 73 63 Gram gram NN cord-018907-c84t1bo5 73 64 - - HYPH cord-018907-c84t1bo5 73 65 positive positive JJ cord-018907-c84t1bo5 73 66 and and CC cord-018907-c84t1bo5 73 67 Gram gram NN cord-018907-c84t1bo5 73 68 - - HYPH cord-018907-c84t1bo5 73 69 negative negative JJ cord-018907-c84t1bo5 73 70 ; ; : cord-018907-c84t1bo5 73 71 for for IN cord-018907-c84t1bo5 73 72 example example NN cord-018907-c84t1bo5 73 73 , , , cord-018907-c84t1bo5 73 74 thirdgeneration thirdgeneration NNP cord-018907-c84t1bo5 73 75 cephalosporin cephalosporin NNP cord-018907-c84t1bo5 73 76 with with IN cord-018907-c84t1bo5 73 77 or or CC cord-018907-c84t1bo5 73 78 without without IN cord-018907-c84t1bo5 73 79 aminoglycoside aminoglycoside NNP cord-018907-c84t1bo5 73 80 with with IN cord-018907-c84t1bo5 73 81 anti anti JJ cord-018907-c84t1bo5 73 82 - - JJ cord-018907-c84t1bo5 73 83 Gram gram JJ cord-018907-c84t1bo5 73 84 - - HYPH cord-018907-c84t1bo5 73 85 positive positive JJ cord-018907-c84t1bo5 73 86 either either CC cord-018907-c84t1bo5 73 87 nafcillin nafcillin NN cord-018907-c84t1bo5 73 88 or or CC cord-018907-c84t1bo5 73 89 vancomycin vancomycin NN cord-018907-c84t1bo5 73 90 based base VBN cord-018907-c84t1bo5 73 91 on on IN cord-018907-c84t1bo5 73 92 the the DT cord-018907-c84t1bo5 73 93 incidence incidence NN cord-018907-c84t1bo5 73 94 of of IN cord-018907-c84t1bo5 73 95 methicillin methicillin NN cord-018907-c84t1bo5 73 96 - - HYPH cord-018907-c84t1bo5 73 97 resistant resistant JJ cord-018907-c84t1bo5 73 98 Staphylococcus Staphylococcus NNP cord-018907-c84t1bo5 73 99 aureus aureus NN cord-018907-c84t1bo5 73 100 ( ( -LRB- cord-018907-c84t1bo5 73 101 MRSA MRSA NNP cord-018907-c84t1bo5 73 102 ) ) -RRB- cord-018907-c84t1bo5 73 103 and and CC cord-018907-c84t1bo5 73 104 penicillin penicillin NN cord-018907-c84t1bo5 73 105 resistant resistant JJ cord-018907-c84t1bo5 73 106 Streptococcus Streptococcus NNP cord-018907-c84t1bo5 73 107 pneumoniae pneumoniae NN cord-018907-c84t1bo5 73 108 . . . cord-018907-c84t1bo5 74 1 The the DT cord-018907-c84t1bo5 74 2 fever fever NN cord-018907-c84t1bo5 74 3 is be VBZ cord-018907-c84t1bo5 74 4 defined define VBN cord-018907-c84t1bo5 74 5 in in IN cord-018907-c84t1bo5 74 6 the the DT cord-018907-c84t1bo5 74 7 context context NN cord-018907-c84t1bo5 74 8 of of IN cord-018907-c84t1bo5 74 9 febrile febrile JJ cord-018907-c84t1bo5 74 10 neutropenia neutropenia NN cord-018907-c84t1bo5 74 11 as as IN cord-018907-c84t1bo5 74 12 a a DT cord-018907-c84t1bo5 74 13 single single JJ cord-018907-c84t1bo5 74 14 oral oral JJ cord-018907-c84t1bo5 74 15 temperature temperature NN cord-018907-c84t1bo5 74 16 of of IN cord-018907-c84t1bo5 74 17 more more JJR cord-018907-c84t1bo5 74 18 than than IN cord-018907-c84t1bo5 74 19 38.3 38.3 CD cord-018907-c84t1bo5 74 20 C c NN cord-018907-c84t1bo5 74 21 or or CC cord-018907-c84t1bo5 74 22 more more JJR cord-018907-c84t1bo5 74 23 than than IN cord-018907-c84t1bo5 74 24 38.0 38.0 CD cord-018907-c84t1bo5 74 25 C c NN cord-018907-c84t1bo5 74 26 for for IN cord-018907-c84t1bo5 74 27 at at RB cord-018907-c84t1bo5 74 28 least least JJS cord-018907-c84t1bo5 74 29 1 1 CD cord-018907-c84t1bo5 74 30 h h NN cord-018907-c84t1bo5 74 31 and and CC cord-018907-c84t1bo5 74 32 is be VBZ cord-018907-c84t1bo5 74 33 not not RB cord-018907-c84t1bo5 74 34 related relate VBN cord-018907-c84t1bo5 74 35 to to IN cord-018907-c84t1bo5 74 36 the the DT cord-018907-c84t1bo5 74 37 administration administration NN cord-018907-c84t1bo5 74 38 of of IN cord-018907-c84t1bo5 74 39 pyrexial pyrexial JJ cord-018907-c84t1bo5 74 40 agents agent NNS cord-018907-c84t1bo5 74 41 including include VBG cord-018907-c84t1bo5 74 42 blood blood NN cord-018907-c84t1bo5 74 43 , , , cord-018907-c84t1bo5 74 44 blood blood NN cord-018907-c84t1bo5 74 45 product product NN cord-018907-c84t1bo5 74 46 , , , cord-018907-c84t1bo5 74 47 IVIG IVIG NNP cord-018907-c84t1bo5 74 48 , , , cord-018907-c84t1bo5 74 49 and and CC cord-018907-c84t1bo5 74 50 pyrogenic pyrogenic JJ cord-018907-c84t1bo5 74 51 drugs drug NNS cord-018907-c84t1bo5 74 52 , , , cord-018907-c84t1bo5 74 53 especially especially RB cord-018907-c84t1bo5 74 54 Ara Ara NNP cord-018907-c84t1bo5 74 55 C. C. NNP cord-018907-c84t1bo5 74 56 Neutropenia Neutropenia NNP cord-018907-c84t1bo5 74 57 is be VBZ cord-018907-c84t1bo5 74 58 defined define VBN cord-018907-c84t1bo5 74 59 as as IN cord-018907-c84t1bo5 74 60 absolute absolute JJ cord-018907-c84t1bo5 74 61 neutrophil neutrophil NN cord-018907-c84t1bo5 74 62 count count NN cord-018907-c84t1bo5 74 63 ( ( -LRB- cord-018907-c84t1bo5 74 64 ANC ANC NNP cord-018907-c84t1bo5 74 65 ) ) -RRB- cord-018907-c84t1bo5 75 1 less less JJR cord-018907-c84t1bo5 75 2 than than IN cord-018907-c84t1bo5 75 3 500 500 CD cord-018907-c84t1bo5 75 4 / / SYM cord-018907-c84t1bo5 75 5 mm mm NN cord-018907-c84t1bo5 75 6 3 3 CD cord-018907-c84t1bo5 75 7 or or CC cord-018907-c84t1bo5 75 8 less less JJR cord-018907-c84t1bo5 75 9 than than IN cord-018907-c84t1bo5 75 10 1,000 1,000 CD cord-018907-c84t1bo5 75 11 / / SYM cord-018907-c84t1bo5 75 12 mm mm NN cord-018907-c84t1bo5 75 13 3 3 CD cord-018907-c84t1bo5 76 1 with with IN cord-018907-c84t1bo5 76 2 predictive predictive JJ cord-018907-c84t1bo5 76 3 decline decline NN cord-018907-c84t1bo5 76 4 to to IN cord-018907-c84t1bo5 76 5 less less JJR cord-018907-c84t1bo5 76 6 500 500 CD cord-018907-c84t1bo5 76 7 / / SYM cord-018907-c84t1bo5 76 8 mm mm NN cord-018907-c84t1bo5 76 9 3 3 CD cord-018907-c84t1bo5 76 10 48 48 CD cord-018907-c84t1bo5 76 11 h. h. NN cord-018907-c84t1bo5 77 1 The the DT cord-018907-c84t1bo5 77 2 most most RBS cord-018907-c84t1bo5 77 3 important important JJ cord-018907-c84t1bo5 77 4 risk risk NN cord-018907-c84t1bo5 77 5 factor factor NN cord-018907-c84t1bo5 77 6 is be VBZ cord-018907-c84t1bo5 77 7 the the DT cord-018907-c84t1bo5 77 8 presence presence NN cord-018907-c84t1bo5 77 9 of of IN cord-018907-c84t1bo5 77 10 neutropenia neutropenia NNP cord-018907-c84t1bo5 77 11 as as RB cord-018907-c84t1bo5 77 12 well well RB cord-018907-c84t1bo5 77 13 as as IN cord-018907-c84t1bo5 77 14 the the DT cord-018907-c84t1bo5 77 15 degree degree NN cord-018907-c84t1bo5 77 16 and and CC cord-018907-c84t1bo5 77 17 duration duration NN cord-018907-c84t1bo5 77 18 of of IN cord-018907-c84t1bo5 77 19 neutropenia neutropenia NN cord-018907-c84t1bo5 77 20 . . . cord-018907-c84t1bo5 78 1 The the DT cord-018907-c84t1bo5 78 2 lower low JJR cord-018907-c84t1bo5 78 3 the the DT cord-018907-c84t1bo5 78 4 neutrophil neutrophil NN cord-018907-c84t1bo5 78 5 count count NN cord-018907-c84t1bo5 78 6 , , , cord-018907-c84t1bo5 78 7 the the DT cord-018907-c84t1bo5 78 8 higher high JJR cord-018907-c84t1bo5 78 9 the the DT cord-018907-c84t1bo5 78 10 risk risk NN cord-018907-c84t1bo5 78 11 of of IN cord-018907-c84t1bo5 78 12 infection infection NN cord-018907-c84t1bo5 78 13 . . . cord-018907-c84t1bo5 79 1 The the DT cord-018907-c84t1bo5 79 2 longer long RBR cord-018907-c84t1bo5 79 3 the the DT cord-018907-c84t1bo5 79 4 duration duration NN cord-018907-c84t1bo5 79 5 of of IN cord-018907-c84t1bo5 79 6 neutropenia neutropenia NN cord-018907-c84t1bo5 79 7 , , , cord-018907-c84t1bo5 79 8 the the DT cord-018907-c84t1bo5 79 9 higher high JJR cord-018907-c84t1bo5 79 10 the the DT cord-018907-c84t1bo5 79 11 risk risk NN cord-018907-c84t1bo5 79 12 of of IN cord-018907-c84t1bo5 79 13 infection infection NN cord-018907-c84t1bo5 79 14 . . . cord-018907-c84t1bo5 80 1 Usually usually RB cord-018907-c84t1bo5 80 2 , , , cord-018907-c84t1bo5 80 3 neutropenia neutropenia NN cord-018907-c84t1bo5 80 4 is be VBZ cord-018907-c84t1bo5 80 5 considered consider VBN cord-018907-c84t1bo5 80 6 high high JJ cord-018907-c84t1bo5 80 7 risk risk NN cord-018907-c84t1bo5 80 8 if if IN cord-018907-c84t1bo5 80 9 7 7 CD cord-018907-c84t1bo5 80 10 days day NNS cord-018907-c84t1bo5 80 11 and and CC cord-018907-c84t1bo5 80 12 low low JJ cord-018907-c84t1bo5 80 13 risk risk NN cord-018907-c84t1bo5 80 14 < < XX cord-018907-c84t1bo5 80 15 7 7 CD cord-018907-c84t1bo5 80 16 days day NNS cord-018907-c84t1bo5 80 17 . . . cord-018907-c84t1bo5 81 1 Other other JJ cord-018907-c84t1bo5 81 2 risk risk NN cord-018907-c84t1bo5 81 3 factors factor NNS cord-018907-c84t1bo5 81 4 include include VBP cord-018907-c84t1bo5 81 5 associated associate VBN cord-018907-c84t1bo5 81 6 medical medical JJ cord-018907-c84t1bo5 81 7 comorbidity comorbidity NN cord-018907-c84t1bo5 81 8 , , , cord-018907-c84t1bo5 81 9 primary primary JJ cord-018907-c84t1bo5 81 10 disease disease NN cord-018907-c84t1bo5 81 11 , , , cord-018907-c84t1bo5 81 12 and and CC cord-018907-c84t1bo5 81 13 status status NN cord-018907-c84t1bo5 81 14 ( ( -LRB- cord-018907-c84t1bo5 81 15 remission remission NN cord-018907-c84t1bo5 81 16 or or CC cord-018907-c84t1bo5 81 17 relapse relapse NN cord-018907-c84t1bo5 81 18 ) ) -RRB- cord-018907-c84t1bo5 81 19 . . . cord-018907-c84t1bo5 82 1 Low low JJ cord-018907-c84t1bo5 82 2 - - HYPH cord-018907-c84t1bo5 82 3 risk risk NN cord-018907-c84t1bo5 82 4 patients patient NNS cord-018907-c84t1bo5 82 5 are be VBP cord-018907-c84t1bo5 82 6 clinically clinically RB cord-018907-c84t1bo5 82 7 defined define VBN cord-018907-c84t1bo5 82 8 by by IN cord-018907-c84t1bo5 82 9 neutropenia neutropenia NN cord-018907-c84t1bo5 82 10 as as IN cord-018907-c84t1bo5 82 11 anticipated anticipate VBN cord-018907-c84t1bo5 82 12 lasting last VBG cord-018907-c84t1bo5 82 13 less less JJR cord-018907-c84t1bo5 82 14 than than IN cord-018907-c84t1bo5 82 15 7 7 CD cord-018907-c84t1bo5 82 16 days day NNS cord-018907-c84t1bo5 82 17 , , , cord-018907-c84t1bo5 82 18 clinically clinically RB cord-018907-c84t1bo5 82 19 stable stable JJ cord-018907-c84t1bo5 82 20 , , , cord-018907-c84t1bo5 82 21 and and CC cord-018907-c84t1bo5 82 22 having have VBG cord-018907-c84t1bo5 82 23 no no DT cord-018907-c84t1bo5 82 24 medical medical JJ cord-018907-c84t1bo5 82 25 comorbid comorbid NN cord-018907-c84t1bo5 82 26 conditions condition NNS cord-018907-c84t1bo5 82 27 . . . cord-018907-c84t1bo5 83 1 About about RB cord-018907-c84t1bo5 83 2 50 50 CD cord-018907-c84t1bo5 83 3 % % NN cord-018907-c84t1bo5 83 4 of of IN cord-018907-c84t1bo5 83 5 neutropenic neutropenic JJ cord-018907-c84t1bo5 83 6 patients patient NNS cord-018907-c84t1bo5 83 7 who who WP cord-018907-c84t1bo5 83 8 become become VBP cord-018907-c84t1bo5 83 9 febrile febrile JJ cord-018907-c84t1bo5 83 10 have have VBP cord-018907-c84t1bo5 83 11 established establish VBN cord-018907-c84t1bo5 83 12 or or CC cord-018907-c84t1bo5 83 13 occult occult JJ cord-018907-c84t1bo5 83 14 infections infection NNS cord-018907-c84t1bo5 83 15 and and CC cord-018907-c84t1bo5 83 16 about about RB cord-018907-c84t1bo5 83 17 25 25 CD cord-018907-c84t1bo5 83 18 % % NN cord-018907-c84t1bo5 83 19 of of IN cord-018907-c84t1bo5 83 20 patients patient NNS cord-018907-c84t1bo5 83 21 with with IN cord-018907-c84t1bo5 83 22 ANC ANC NNP cord-018907-c84t1bo5 83 23 less less JJR cord-018907-c84t1bo5 83 24 than than IN cord-018907-c84t1bo5 83 25 100 100 CD cord-018907-c84t1bo5 83 26 cells cell NNS cord-018907-c84t1bo5 83 27 / / SYM cord-018907-c84t1bo5 83 28 mm mm NN cord-018907-c84t1bo5 83 29 3 3 CD cord-018907-c84t1bo5 83 30 have have VBP cord-018907-c84t1bo5 83 31 bacteremia bacteremia NN cord-018907-c84t1bo5 83 32 . . . cord-018907-c84t1bo5 84 1 The the DT cord-018907-c84t1bo5 84 2 risk risk NN cord-018907-c84t1bo5 84 3 varies vary VBZ cord-018907-c84t1bo5 84 4 depending depend VBG cord-018907-c84t1bo5 84 5 on on IN cord-018907-c84t1bo5 84 6 the the DT cord-018907-c84t1bo5 84 7 underlying underlie VBG cord-018907-c84t1bo5 84 8 disease disease NN cord-018907-c84t1bo5 84 9 , , , cord-018907-c84t1bo5 84 10 for for IN cord-018907-c84t1bo5 84 11 example example NN cord-018907-c84t1bo5 84 12 , , , cord-018907-c84t1bo5 84 13 patients patient NNS cord-018907-c84t1bo5 84 14 post post VBP cord-018907-c84t1bo5 84 15 allogenic allogenic JJ cord-018907-c84t1bo5 84 16 bone bone NN cord-018907-c84t1bo5 84 17 marrow marrow NN cord-018907-c84t1bo5 84 18 transplantation transplantation NN cord-018907-c84t1bo5 84 19 are be VBP cord-018907-c84t1bo5 84 20 at at IN cord-018907-c84t1bo5 84 21 higher high JJR cord-018907-c84t1bo5 84 22 risk risk NN cord-018907-c84t1bo5 84 23 than than IN cord-018907-c84t1bo5 84 24 autologous autologous JJ cord-018907-c84t1bo5 84 25 bone bone NN cord-018907-c84t1bo5 84 26 marrow marrow NN cord-018907-c84t1bo5 84 27 transplantation transplantation NN cord-018907-c84t1bo5 84 28 while while IN cord-018907-c84t1bo5 84 29 AML AML NNP cord-018907-c84t1bo5 84 30 has have VBZ cord-018907-c84t1bo5 84 31 the the DT cord-018907-c84t1bo5 84 32 higher high JJR cord-018907-c84t1bo5 84 33 risk risk NN cord-018907-c84t1bo5 84 34 than than IN cord-018907-c84t1bo5 84 35 ALL all DT cord-018907-c84t1bo5 84 36 . . . cord-018907-c84t1bo5 85 1 The the DT cord-018907-c84t1bo5 85 2 lowest low JJS cord-018907-c84t1bo5 85 3 risk risk NN cord-018907-c84t1bo5 85 4 is be VBZ cord-018907-c84t1bo5 85 5 in in IN cord-018907-c84t1bo5 85 6 patients patient NNS cord-018907-c84t1bo5 85 7 with with IN cord-018907-c84t1bo5 85 8 cyclic cyclic JJ cord-018907-c84t1bo5 85 9 neutropenia neutropenia NN cord-018907-c84t1bo5 85 10 . . . cord-018907-c84t1bo5 86 1 In in IN cord-018907-c84t1bo5 86 2 evaluating evaluate VBG cord-018907-c84t1bo5 86 3 a a DT cord-018907-c84t1bo5 86 4 patient patient NN cord-018907-c84t1bo5 86 5 with with IN cord-018907-c84t1bo5 86 6 fever fever NN cord-018907-c84t1bo5 86 7 and and CC cord-018907-c84t1bo5 86 8 neutropenia neutropenia NN cord-018907-c84t1bo5 86 9 , , , cord-018907-c84t1bo5 86 10 it -PRON- PRP cord-018907-c84t1bo5 86 11 is be VBZ cord-018907-c84t1bo5 86 12 important important JJ cord-018907-c84t1bo5 86 13 to to TO cord-018907-c84t1bo5 86 14 keep keep VB cord-018907-c84t1bo5 86 15 in in IN cord-018907-c84t1bo5 86 16 mind mind NN cord-018907-c84t1bo5 86 17 that that IN cord-018907-c84t1bo5 86 18 signs sign NNS cord-018907-c84t1bo5 86 19 and and CC cord-018907-c84t1bo5 86 20 symptoms symptom NNS cord-018907-c84t1bo5 86 21 can can MD cord-018907-c84t1bo5 86 22 be be VB cord-018907-c84t1bo5 86 23 muted mute VBN cord-018907-c84t1bo5 86 24 or or CC cord-018907-c84t1bo5 86 25 subtle subtle JJ cord-018907-c84t1bo5 86 26 . . . cord-018907-c84t1bo5 87 1 Profoundly profoundly RB cord-018907-c84t1bo5 87 2 neutropenic neutropenic JJ cord-018907-c84t1bo5 87 3 patients patient NNS cord-018907-c84t1bo5 87 4 can can MD cord-018907-c84t1bo5 87 5 sometime sometime RB cord-018907-c84t1bo5 87 6 have have VB cord-018907-c84t1bo5 87 7 life life NN cord-018907-c84t1bo5 87 8 - - HYPH cord-018907-c84t1bo5 87 9 threatening threaten VBG cord-018907-c84t1bo5 87 10 infections infection NNS cord-018907-c84t1bo5 87 11 and and CC cord-018907-c84t1bo5 87 12 yet yet RB cord-018907-c84t1bo5 87 13 be be VB cord-018907-c84t1bo5 87 14 afebrile afebrile JJ cord-018907-c84t1bo5 87 15 especially especially RB cord-018907-c84t1bo5 87 16 if if IN cord-018907-c84t1bo5 87 17 they -PRON- PRP cord-018907-c84t1bo5 87 18 presented present VBD cord-018907-c84t1bo5 87 19 with with IN cord-018907-c84t1bo5 87 20 abdominal abdominal JJ cord-018907-c84t1bo5 87 21 pain pain NN cord-018907-c84t1bo5 87 22 . . . cord-018907-c84t1bo5 88 1 Careful careful JJ cord-018907-c84t1bo5 88 2 and and CC cord-018907-c84t1bo5 88 3 comprehensive comprehensive JJ cord-018907-c84t1bo5 88 4 physical physical JJ cord-018907-c84t1bo5 88 5 examination examination NN cord-018907-c84t1bo5 88 6 is be VBZ cord-018907-c84t1bo5 88 7 critical critical JJ cord-018907-c84t1bo5 88 8 and and CC cord-018907-c84t1bo5 88 9 should should MD cord-018907-c84t1bo5 88 10 be be VB cord-018907-c84t1bo5 88 11 repeated repeat VBN cord-018907-c84t1bo5 88 12 at at IN cord-018907-c84t1bo5 88 13 least least JJS cord-018907-c84t1bo5 88 14 daily daily RB cord-018907-c84t1bo5 88 15 because because IN cord-018907-c84t1bo5 88 16 these these DT cord-018907-c84t1bo5 88 17 patients patient NNS cord-018907-c84t1bo5 88 18 are be VBP cord-018907-c84t1bo5 88 19 dynamic dynamic JJ cord-018907-c84t1bo5 88 20 and and CC cord-018907-c84t1bo5 88 21 their -PRON- PRP$ cord-018907-c84t1bo5 88 22 condition condition NN cord-018907-c84t1bo5 88 23 can can MD cord-018907-c84t1bo5 88 24 change change VB cord-018907-c84t1bo5 88 25 rapidly rapidly RB cord-018907-c84t1bo5 88 26 . . . cord-018907-c84t1bo5 89 1 Other other JJ cord-018907-c84t1bo5 89 2 important important JJ cord-018907-c84t1bo5 89 3 points point NNS cord-018907-c84t1bo5 89 4 in in IN cord-018907-c84t1bo5 89 5 the the DT cord-018907-c84t1bo5 89 6 history history NN cord-018907-c84t1bo5 89 7 include include VBP cord-018907-c84t1bo5 89 8 the the DT cord-018907-c84t1bo5 89 9 nature nature NN cord-018907-c84t1bo5 89 10 of of IN cord-018907-c84t1bo5 89 11 chemotherapeutic chemotherapeutic JJ cord-018907-c84t1bo5 89 12 agents agent NNS cord-018907-c84t1bo5 89 13 , , , cord-018907-c84t1bo5 89 14 steroids steroid NNS cord-018907-c84t1bo5 89 15 , , , cord-018907-c84t1bo5 89 16 or or CC cord-018907-c84t1bo5 89 17 other other JJ cord-018907-c84t1bo5 89 18 immunosuppressive immunosuppressive JJ cord-018907-c84t1bo5 89 19 agents agent NNS cord-018907-c84t1bo5 89 20 because because IN cord-018907-c84t1bo5 89 21 these these DT cord-018907-c84t1bo5 89 22 can can MD cord-018907-c84t1bo5 89 23 predict predict VB cord-018907-c84t1bo5 89 24 the the DT cord-018907-c84t1bo5 89 25 degree degree NN cord-018907-c84t1bo5 89 26 of of IN cord-018907-c84t1bo5 89 27 immunosuppression immunosuppression NN cord-018907-c84t1bo5 89 28 , , , cord-018907-c84t1bo5 89 29 the the DT cord-018907-c84t1bo5 89 30 duration duration NN cord-018907-c84t1bo5 89 31 of of IN cord-018907-c84t1bo5 89 32 neutropenia neutropenia NN cord-018907-c84t1bo5 89 33 , , , cord-018907-c84t1bo5 89 34 and and CC cord-018907-c84t1bo5 89 35 the the DT cord-018907-c84t1bo5 89 36 severity severity NN cord-018907-c84t1bo5 89 37 of of IN cord-018907-c84t1bo5 89 38 neutropenia neutropenia NN cord-018907-c84t1bo5 89 39 . . . cord-018907-c84t1bo5 90 1 The the DT cord-018907-c84t1bo5 90 2 history history NN cord-018907-c84t1bo5 90 3 of of IN cord-018907-c84t1bo5 90 4 antibiotic antibiotic JJ cord-018907-c84t1bo5 90 5 prophylaxis prophylaxis NN cord-018907-c84t1bo5 90 6 is be VBZ cord-018907-c84t1bo5 90 7 also also RB cord-018907-c84t1bo5 90 8 important important JJ cord-018907-c84t1bo5 90 9 because because IN cord-018907-c84t1bo5 90 10 the the DT cord-018907-c84t1bo5 90 11 antibiotic antibiotic NN cord-018907-c84t1bo5 90 12 used use VBN cord-018907-c84t1bo5 90 13 as as IN cord-018907-c84t1bo5 90 14 prophylaxis prophylaxis NN cord-018907-c84t1bo5 90 15 should should MD cord-018907-c84t1bo5 90 16 be be VB cord-018907-c84t1bo5 90 17 avoided avoid VBN cord-018907-c84t1bo5 90 18 in in IN cord-018907-c84t1bo5 90 19 treating treat VBG cord-018907-c84t1bo5 90 20 these these DT cord-018907-c84t1bo5 90 21 patients patient NNS cord-018907-c84t1bo5 90 22 . . . cord-018907-c84t1bo5 91 1 Reviewing review VBG cord-018907-c84t1bo5 91 2 the the DT cord-018907-c84t1bo5 91 3 recent recent JJ cord-018907-c84t1bo5 91 4 documented document VBN cord-018907-c84t1bo5 91 5 infection infection NN cord-018907-c84t1bo5 91 6 with with IN cord-018907-c84t1bo5 91 7 susceptibility susceptibility NN cord-018907-c84t1bo5 91 8 can can MD cord-018907-c84t1bo5 91 9 help help VB cord-018907-c84t1bo5 91 10 in in IN cord-018907-c84t1bo5 91 11 determining determine VBG cord-018907-c84t1bo5 91 12 the the DT cord-018907-c84t1bo5 91 13 empiric empiric JJ cord-018907-c84t1bo5 91 14 therapy therapy NN cord-018907-c84t1bo5 91 15 . . . cord-018907-c84t1bo5 92 1 For for IN cord-018907-c84t1bo5 92 2 example example NN cord-018907-c84t1bo5 92 3 , , , cord-018907-c84t1bo5 92 4 if if IN cord-018907-c84t1bo5 92 5 the the DT cord-018907-c84t1bo5 92 6 patient patient NN cord-018907-c84t1bo5 92 7 has have VBZ cord-018907-c84t1bo5 92 8 a a DT cord-018907-c84t1bo5 92 9 previous previous JJ cord-018907-c84t1bo5 92 10 infection infection NN cord-018907-c84t1bo5 92 11 with with IN cord-018907-c84t1bo5 92 12 multidrug multidrug NN cord-018907-c84t1bo5 92 13 resistance resistance NN cord-018907-c84t1bo5 92 14 pathogen pathogen NN cord-018907-c84t1bo5 92 15 , , , cord-018907-c84t1bo5 92 16 empiric empiric JJ cord-018907-c84t1bo5 92 17 therapy therapy NN cord-018907-c84t1bo5 92 18 can can MD cord-018907-c84t1bo5 92 19 be be VB cord-018907-c84t1bo5 92 20 used use VBN cord-018907-c84t1bo5 92 21 to to TO cord-018907-c84t1bo5 92 22 cover cover VB cord-018907-c84t1bo5 92 23 these these DT cord-018907-c84t1bo5 92 24 pathogens pathogen NNS cord-018907-c84t1bo5 92 25 . . . cord-018907-c84t1bo5 93 1 If if IN cord-018907-c84t1bo5 93 2 the the DT cord-018907-c84t1bo5 93 3 patient patient NN cord-018907-c84t1bo5 93 4 had have VBD cord-018907-c84t1bo5 93 5 recent recent JJ cord-018907-c84t1bo5 93 6 surgical surgical JJ cord-018907-c84t1bo5 93 7 procedure procedure NN cord-018907-c84t1bo5 93 8 , , , cord-018907-c84t1bo5 93 9 this this DT cord-018907-c84t1bo5 93 10 means mean VBZ cord-018907-c84t1bo5 93 11 there there EX cord-018907-c84t1bo5 93 12 is be VBZ cord-018907-c84t1bo5 93 13 break break NN cord-018907-c84t1bo5 93 14 of of IN cord-018907-c84t1bo5 93 15 the the DT cord-018907-c84t1bo5 93 16 skin skin NN cord-018907-c84t1bo5 93 17 and and CC cord-018907-c84t1bo5 93 18 is be VBZ cord-018907-c84t1bo5 93 19 at at IN cord-018907-c84t1bo5 93 20 risk risk NN cord-018907-c84t1bo5 93 21 for for IN cord-018907-c84t1bo5 93 22 certain certain JJ cord-018907-c84t1bo5 93 23 pathogens pathogen NNS cord-018907-c84t1bo5 93 24 including include VBG cord-018907-c84t1bo5 93 25 Grampositive Grampositive NNP cord-018907-c84t1bo5 93 26 cocci coccus NNS cord-018907-c84t1bo5 93 27 ( ( -LRB- cord-018907-c84t1bo5 93 28 coagulase coagulase NN cord-018907-c84t1bo5 93 29 negative negative JJ cord-018907-c84t1bo5 93 30 Staphylococci Staphylococci NNP cord-018907-c84t1bo5 93 31 and and CC cord-018907-c84t1bo5 93 32 Staphylococcus Staphylococcus NNP cord-018907-c84t1bo5 93 33 aureus aureus NN cord-018907-c84t1bo5 93 34 ) ) -RRB- cord-018907-c84t1bo5 93 35 . . . cord-018907-c84t1bo5 94 1 Allergy allergy NN cord-018907-c84t1bo5 94 2 history history NN cord-018907-c84t1bo5 94 3 is be VBZ cord-018907-c84t1bo5 94 4 an an DT cord-018907-c84t1bo5 94 5 important important JJ cord-018907-c84t1bo5 94 6 factor factor NN cord-018907-c84t1bo5 94 7 in in IN cord-018907-c84t1bo5 94 8 selecting select VBG cord-018907-c84t1bo5 94 9 empirical empirical JJ cord-018907-c84t1bo5 94 10 therapy therapy NN cord-018907-c84t1bo5 94 11 as as IN cord-018907-c84t1bo5 94 12 allergic allergic JJ cord-018907-c84t1bo5 94 13 medications medication NNS cord-018907-c84t1bo5 94 14 need need VBP cord-018907-c84t1bo5 94 15 to to TO cord-018907-c84t1bo5 94 16 be be VB cord-018907-c84t1bo5 94 17 avoided avoid VBN cord-018907-c84t1bo5 94 18 . . . cord-018907-c84t1bo5 95 1 Detailed detailed JJ cord-018907-c84t1bo5 95 2 and and CC cord-018907-c84t1bo5 95 3 thorough thorough JJ cord-018907-c84t1bo5 95 4 physical physical JJ cord-018907-c84t1bo5 95 5 examination examination NN cord-018907-c84t1bo5 95 6 is be VBZ cord-018907-c84t1bo5 95 7 important important JJ cord-018907-c84t1bo5 95 8 with with IN cord-018907-c84t1bo5 95 9 focus focus NN cord-018907-c84t1bo5 95 10 on on IN cord-018907-c84t1bo5 95 11 certain certain JJ cord-018907-c84t1bo5 95 12 sites site NNS cord-018907-c84t1bo5 95 13 that that WDT cord-018907-c84t1bo5 95 14 can can MD cord-018907-c84t1bo5 95 15 be be VB cord-018907-c84t1bo5 95 16 a a DT cord-018907-c84t1bo5 95 17 portal portal NN cord-018907-c84t1bo5 95 18 of of IN cord-018907-c84t1bo5 95 19 entry entry NN cord-018907-c84t1bo5 95 20 of of IN cord-018907-c84t1bo5 95 21 pathogens pathogen NNS cord-018907-c84t1bo5 95 22 including include VBG cord-018907-c84t1bo5 95 23 periodontium periodontium NN cord-018907-c84t1bo5 95 24 , , , cord-018907-c84t1bo5 95 25 pharynx pharynx NN cord-018907-c84t1bo5 95 26 , , , cord-018907-c84t1bo5 95 27 lower lower VB cord-018907-c84t1bo5 95 28 esophagus esophagus NN cord-018907-c84t1bo5 95 29 , , , cord-018907-c84t1bo5 95 30 lung lung NN cord-018907-c84t1bo5 95 31 , , , cord-018907-c84t1bo5 95 32 skin skin NN cord-018907-c84t1bo5 95 33 , , , cord-018907-c84t1bo5 95 34 perineum perineum NN cord-018907-c84t1bo5 95 35 , , , cord-018907-c84t1bo5 95 36 bone bone NN cord-018907-c84t1bo5 95 37 marrow marrow NN cord-018907-c84t1bo5 95 38 aspiration aspiration NN cord-018907-c84t1bo5 95 39 site site NN cord-018907-c84t1bo5 95 40 , , , cord-018907-c84t1bo5 95 41 and and CC cord-018907-c84t1bo5 95 42 catheter catheter NN cord-018907-c84t1bo5 95 43 entry entry NN cord-018907-c84t1bo5 95 44 and and CC cord-018907-c84t1bo5 95 45 exit exit NN cord-018907-c84t1bo5 95 46 sites site NNS cord-018907-c84t1bo5 95 47 . . . cord-018907-c84t1bo5 96 1 After after IN cord-018907-c84t1bo5 96 2 history history NN cord-018907-c84t1bo5 96 3 and and CC cord-018907-c84t1bo5 96 4 thorough thorough JJ cord-018907-c84t1bo5 96 5 physical physical JJ cord-018907-c84t1bo5 96 6 examinations examination NNS cord-018907-c84t1bo5 96 7 , , , cord-018907-c84t1bo5 96 8 blood blood NN cord-018907-c84t1bo5 96 9 culture culture NN cord-018907-c84t1bo5 96 10 from from IN cord-018907-c84t1bo5 96 11 central central JJ cord-018907-c84t1bo5 96 12 and and CC cord-018907-c84t1bo5 96 13 peripheral peripheral JJ cord-018907-c84t1bo5 96 14 lines line NNS cord-018907-c84t1bo5 96 15 should should MD cord-018907-c84t1bo5 96 16 done do VBN cord-018907-c84t1bo5 96 17 in in IN cord-018907-c84t1bo5 96 18 order order NN cord-018907-c84t1bo5 96 19 to to TO cord-018907-c84t1bo5 96 20 identify identify VB cord-018907-c84t1bo5 96 21 the the DT cord-018907-c84t1bo5 96 22 source source NN cord-018907-c84t1bo5 96 23 of of IN cord-018907-c84t1bo5 96 24 infection infection NN cord-018907-c84t1bo5 96 25 . . . cord-018907-c84t1bo5 97 1 For for IN cord-018907-c84t1bo5 97 2 example example NN cord-018907-c84t1bo5 97 3 , , , cord-018907-c84t1bo5 97 4 if if IN cord-018907-c84t1bo5 97 5 the the DT cord-018907-c84t1bo5 97 6 blood blood NN cord-018907-c84t1bo5 97 7 culture culture NN cord-018907-c84t1bo5 97 8 is be VBZ cord-018907-c84t1bo5 97 9 positive positive JJ cord-018907-c84t1bo5 97 10 from from IN cord-018907-c84t1bo5 97 11 the the DT cord-018907-c84t1bo5 97 12 central central JJ cord-018907-c84t1bo5 97 13 culture culture NN cord-018907-c84t1bo5 97 14 but but CC cord-018907-c84t1bo5 97 15 negative negative JJ cord-018907-c84t1bo5 97 16 from from IN cord-018907-c84t1bo5 97 17 peripheral peripheral JJ cord-018907-c84t1bo5 97 18 culture culture NN cord-018907-c84t1bo5 97 19 , , , cord-018907-c84t1bo5 97 20 the the DT cord-018907-c84t1bo5 97 21 likely likely JJ cord-018907-c84t1bo5 97 22 source source NN cord-018907-c84t1bo5 97 23 is be VBZ cord-018907-c84t1bo5 97 24 the the DT cord-018907-c84t1bo5 97 25 central central JJ cord-018907-c84t1bo5 97 26 line line NN cord-018907-c84t1bo5 97 27 . . . cord-018907-c84t1bo5 98 1 If if IN cord-018907-c84t1bo5 98 2 both both DT cord-018907-c84t1bo5 98 3 are be VBP cord-018907-c84t1bo5 98 4 positive positive JJ cord-018907-c84t1bo5 98 5 , , , cord-018907-c84t1bo5 98 6 time time NN cord-018907-c84t1bo5 98 7 is be VBZ cord-018907-c84t1bo5 98 8 needed need VBN cord-018907-c84t1bo5 98 9 to to TO cord-018907-c84t1bo5 98 10 positively positively RB cord-018907-c84t1bo5 98 11 determine determine VB cord-018907-c84t1bo5 98 12 the the DT cord-018907-c84t1bo5 98 13 source source NN cord-018907-c84t1bo5 98 14 of of IN cord-018907-c84t1bo5 98 15 infection infection NN cord-018907-c84t1bo5 98 16 . . . cord-018907-c84t1bo5 99 1 Routine routine JJ cord-018907-c84t1bo5 99 2 surveillance surveillance NN cord-018907-c84t1bo5 99 3 culture culture NN cord-018907-c84t1bo5 99 4 is be VBZ cord-018907-c84t1bo5 99 5 not not RB cord-018907-c84t1bo5 99 6 indicated indicate VBN cord-018907-c84t1bo5 99 7 as as IN cord-018907-c84t1bo5 99 8 it -PRON- PRP cord-018907-c84t1bo5 99 9 is be VBZ cord-018907-c84t1bo5 99 10 not not RB cord-018907-c84t1bo5 99 11 cost cost VBN cord-018907-c84t1bo5 99 12 effective effective JJ cord-018907-c84t1bo5 99 13 and and CC cord-018907-c84t1bo5 99 14 has have VBZ cord-018907-c84t1bo5 99 15 low low JJ cord-018907-c84t1bo5 99 16 predictive predictive JJ cord-018907-c84t1bo5 99 17 value value NN cord-018907-c84t1bo5 99 18 . . . cord-018907-c84t1bo5 100 1 Other other JJ cord-018907-c84t1bo5 100 2 cultures culture NNS cord-018907-c84t1bo5 100 3 should should MD cord-018907-c84t1bo5 100 4 be be VB cord-018907-c84t1bo5 100 5 guided guide VBN cord-018907-c84t1bo5 100 6 by by IN cord-018907-c84t1bo5 100 7 the the DT cord-018907-c84t1bo5 100 8 sites site NNS cord-018907-c84t1bo5 100 9 of of IN cord-018907-c84t1bo5 100 10 infection infection NN cord-018907-c84t1bo5 100 11 . . . cord-018907-c84t1bo5 101 1 For for IN cord-018907-c84t1bo5 101 2 example example NN cord-018907-c84t1bo5 101 3 , , , cord-018907-c84t1bo5 101 4 a a DT cord-018907-c84t1bo5 101 5 patient patient NN cord-018907-c84t1bo5 101 6 with with IN cord-018907-c84t1bo5 101 7 respiratory respiratory JJ cord-018907-c84t1bo5 101 8 symptoms symptom NNS cord-018907-c84t1bo5 101 9 needs need VBZ cord-018907-c84t1bo5 101 10 to to TO cord-018907-c84t1bo5 101 11 have have VB cord-018907-c84t1bo5 101 12 nasapharyngeal nasapharyngeal JJ cord-018907-c84t1bo5 101 13 aspirate aspirate NN cord-018907-c84t1bo5 101 14 for for IN cord-018907-c84t1bo5 101 15 viral viral JJ cord-018907-c84t1bo5 101 16 study study NN cord-018907-c84t1bo5 101 17 , , , cord-018907-c84t1bo5 101 18 PCR PCR NNP cord-018907-c84t1bo5 101 19 multiplex multiplex NN cord-018907-c84t1bo5 101 20 , , , cord-018907-c84t1bo5 101 21 and and CC cord-018907-c84t1bo5 101 22 atypical atypical JJ cord-018907-c84t1bo5 101 23 pneumonia pneumonia NN cord-018907-c84t1bo5 101 24 . . . cord-018907-c84t1bo5 102 1 Patients patient NNS cord-018907-c84t1bo5 102 2 with with IN cord-018907-c84t1bo5 102 3 gastrointestinal gastrointestinal JJ cord-018907-c84t1bo5 102 4 symptoms symptom NNS cord-018907-c84t1bo5 102 5 , , , cord-018907-c84t1bo5 102 6 for for IN cord-018907-c84t1bo5 102 7 example example NN cord-018907-c84t1bo5 102 8 , , , cord-018907-c84t1bo5 102 9 with with IN cord-018907-c84t1bo5 102 10 diarrhea diarrhea NN cord-018907-c84t1bo5 102 11 , , , cord-018907-c84t1bo5 102 12 the the DT cord-018907-c84t1bo5 102 13 stool stool NN cord-018907-c84t1bo5 102 14 needs need VBZ cord-018907-c84t1bo5 102 15 to to TO cord-018907-c84t1bo5 102 16 be be VB cord-018907-c84t1bo5 102 17 sent send VBN cord-018907-c84t1bo5 102 18 for for IN cord-018907-c84t1bo5 102 19 viral viral JJ cord-018907-c84t1bo5 102 20 study study NN cord-018907-c84t1bo5 102 21 , , , cord-018907-c84t1bo5 102 22 culture culture NN cord-018907-c84t1bo5 102 23 and and CC cord-018907-c84t1bo5 102 24 sensitivity sensitivity NN cord-018907-c84t1bo5 102 25 , , , cord-018907-c84t1bo5 102 26 ova ova NN cord-018907-c84t1bo5 102 27 and and CC cord-018907-c84t1bo5 102 28 parasite parasite NN cord-018907-c84t1bo5 102 29 . . . cord-018907-c84t1bo5 103 1 Chest chest NN cord-018907-c84t1bo5 103 2 X x NN cord-018907-c84t1bo5 103 3 - - NN cord-018907-c84t1bo5 103 4 ray ray NN cord-018907-c84t1bo5 103 5 should should MD cord-018907-c84t1bo5 103 6 not not RB cord-018907-c84t1bo5 103 7 be be VB cord-018907-c84t1bo5 103 8 done do VBN cord-018907-c84t1bo5 103 9 routinely routinely RB cord-018907-c84t1bo5 103 10 in in IN cord-018907-c84t1bo5 103 11 all all DT cord-018907-c84t1bo5 103 12 patients patient NNS cord-018907-c84t1bo5 103 13 with with IN cord-018907-c84t1bo5 103 14 fever fever NN cord-018907-c84t1bo5 103 15 and and CC cord-018907-c84t1bo5 103 16 neutropenia neutropenia NN cord-018907-c84t1bo5 103 17 because because IN cord-018907-c84t1bo5 103 18 it -PRON- PRP cord-018907-c84t1bo5 103 19 has have VBZ cord-018907-c84t1bo5 103 20 low low JJ cord-018907-c84t1bo5 103 21 yield yield NN cord-018907-c84t1bo5 103 22 in in IN cord-018907-c84t1bo5 103 23 patients patient NNS cord-018907-c84t1bo5 103 24 without without IN cord-018907-c84t1bo5 103 25 respiratory respiratory JJ cord-018907-c84t1bo5 103 26 symptoms symptom NNS cord-018907-c84t1bo5 103 27 . . . cord-018907-c84t1bo5 104 1 It -PRON- PRP cord-018907-c84t1bo5 104 2 is be VBZ cord-018907-c84t1bo5 104 3 only only RB cord-018907-c84t1bo5 104 4 done do VBN cord-018907-c84t1bo5 104 5 in in IN cord-018907-c84t1bo5 104 6 children child NNS cord-018907-c84t1bo5 104 7 who who WP cord-018907-c84t1bo5 104 8 have have VBP cord-018907-c84t1bo5 104 9 respiratory respiratory JJ cord-018907-c84t1bo5 104 10 symptoms symptom NNS cord-018907-c84t1bo5 104 11 . . . cord-018907-c84t1bo5 105 1 If if IN cord-018907-c84t1bo5 105 2 negative negative JJ cord-018907-c84t1bo5 105 3 , , , cord-018907-c84t1bo5 105 4 a a DT cord-018907-c84t1bo5 105 5 chest chest NN cord-018907-c84t1bo5 105 6 CT CT NNP cord-018907-c84t1bo5 105 7 scan scan NN cord-018907-c84t1bo5 105 8 to to TO cord-018907-c84t1bo5 105 9 be be VB cord-018907-c84t1bo5 105 10 considered consider VBN cord-018907-c84t1bo5 105 11 to to TO cord-018907-c84t1bo5 105 12 better better RB cord-018907-c84t1bo5 105 13 evaluate evaluate VB cord-018907-c84t1bo5 105 14 patient patient NN cord-018907-c84t1bo5 105 15 not not RB cord-018907-c84t1bo5 105 16 responding respond VBG cord-018907-c84t1bo5 105 17 to to IN cord-018907-c84t1bo5 105 18 therapy therapy NN cord-018907-c84t1bo5 105 19 . . . cord-018907-c84t1bo5 106 1 Most Most JJS cord-018907-c84t1bo5 106 2 patients patient NNS cord-018907-c84t1bo5 106 3 with with IN cord-018907-c84t1bo5 106 4 fever fever NN cord-018907-c84t1bo5 106 5 and and CC cord-018907-c84t1bo5 106 6 neutropenia neutropenia NN cord-018907-c84t1bo5 106 7 have have VBP cord-018907-c84t1bo5 106 8 no no DT cord-018907-c84t1bo5 106 9 identifiable identifiable JJ cord-018907-c84t1bo5 106 10 site site NN cord-018907-c84t1bo5 106 11 of of IN cord-018907-c84t1bo5 106 12 infection infection NN cord-018907-c84t1bo5 106 13 and and CC cord-018907-c84t1bo5 106 14 no no DT cord-018907-c84t1bo5 106 15 positive positive JJ cord-018907-c84t1bo5 106 16 culture culture NN cord-018907-c84t1bo5 106 17 results result NNS cord-018907-c84t1bo5 106 18 . . . cord-018907-c84t1bo5 107 1 Bloodstream bloodstream NN cord-018907-c84t1bo5 107 2 infection infection NN cord-018907-c84t1bo5 107 3 is be VBZ cord-018907-c84t1bo5 107 4 documented document VBN cord-018907-c84t1bo5 107 5 in in IN cord-018907-c84t1bo5 107 6 about about RB cord-018907-c84t1bo5 107 7 20 20 CD cord-018907-c84t1bo5 107 8 % % NN cord-018907-c84t1bo5 107 9 of of IN cord-018907-c84t1bo5 107 10 patients patient NNS cord-018907-c84t1bo5 107 11 with with IN cord-018907-c84t1bo5 107 12 fever fever NN cord-018907-c84t1bo5 107 13 and and CC cord-018907-c84t1bo5 107 14 neutropenia neutropenia NN cord-018907-c84t1bo5 107 15 . . . cord-018907-c84t1bo5 108 1 Disruption disruption NN cord-018907-c84t1bo5 108 2 of of IN cord-018907-c84t1bo5 108 3 the the DT cord-018907-c84t1bo5 108 4 skin skin NN cord-018907-c84t1bo5 108 5 or or CC cord-018907-c84t1bo5 108 6 soft soft JJ cord-018907-c84t1bo5 108 7 tissue tissue NN cord-018907-c84t1bo5 108 8 including include VBG cord-018907-c84t1bo5 108 9 vascular vascular JJ cord-018907-c84t1bo5 108 10 access access NN cord-018907-c84t1bo5 108 11 or or CC cord-018907-c84t1bo5 108 12 catheter catheter NN cord-018907-c84t1bo5 108 13 insertion insertion NN cord-018907-c84t1bo5 108 14 site site NN cord-018907-c84t1bo5 108 15 can can MD cord-018907-c84t1bo5 108 16 be be VB cord-018907-c84t1bo5 108 17 a a DT cord-018907-c84t1bo5 108 18 point point NN cord-018907-c84t1bo5 108 19 of of IN cord-018907-c84t1bo5 108 20 entry entry NN cord-018907-c84t1bo5 108 21 . . . cord-018907-c84t1bo5 109 1 In in IN cord-018907-c84t1bo5 109 2 those those DT cord-018907-c84t1bo5 109 3 centers center NNS cord-018907-c84t1bo5 109 4 , , , cord-018907-c84t1bo5 109 5 who who WP cord-018907-c84t1bo5 109 6 are be VBP cord-018907-c84t1bo5 109 7 dealing deal VBG cord-018907-c84t1bo5 109 8 with with IN cord-018907-c84t1bo5 109 9 cancer cancer NN cord-018907-c84t1bo5 109 10 patients patient NNS cord-018907-c84t1bo5 109 11 , , , cord-018907-c84t1bo5 109 12 it -PRON- PRP cord-018907-c84t1bo5 109 13 is be VBZ cord-018907-c84t1bo5 109 14 very very RB cord-018907-c84t1bo5 109 15 important important JJ cord-018907-c84t1bo5 109 16 to to TO cord-018907-c84t1bo5 109 17 monitor monitor VB cord-018907-c84t1bo5 109 18 the the DT cord-018907-c84t1bo5 109 19 infection infection NN cord-018907-c84t1bo5 109 20 rate rate NN cord-018907-c84t1bo5 109 21 and and CC cord-018907-c84t1bo5 109 22 pathogen pathogen NN cord-018907-c84t1bo5 109 23 as as RB cord-018907-c84t1bo5 109 24 well well RB cord-018907-c84t1bo5 109 25 as as IN cord-018907-c84t1bo5 109 26 the the DT cord-018907-c84t1bo5 109 27 resistance resistance NN cord-018907-c84t1bo5 109 28 pattern pattern NN cord-018907-c84t1bo5 109 29 in in IN cord-018907-c84t1bo5 109 30 the the DT cord-018907-c84t1bo5 109 31 same same JJ cord-018907-c84t1bo5 109 32 center center NN cord-018907-c84t1bo5 109 33 . . . cord-018907-c84t1bo5 110 1 The the DT cord-018907-c84t1bo5 110 2 local local JJ cord-018907-c84t1bo5 110 3 data datum NNS cord-018907-c84t1bo5 110 4 will will MD cord-018907-c84t1bo5 110 5 help help VB cord-018907-c84t1bo5 110 6 to to TO cord-018907-c84t1bo5 110 7 select select VB cord-018907-c84t1bo5 110 8 the the DT cord-018907-c84t1bo5 110 9 appropriate appropriate JJ cord-018907-c84t1bo5 110 10 empirical empirical JJ cord-018907-c84t1bo5 110 11 antimicrobial antimicrobial JJ cord-018907-c84t1bo5 110 12 therapy therapy NN cord-018907-c84t1bo5 110 13 ( ( -LRB- cord-018907-c84t1bo5 110 14 > > XX cord-018907-c84t1bo5 111 1 Table table NN cord-018907-c84t1bo5 111 2 68 68 CD cord-018907-c84t1bo5 111 3 .1 .1 CD cord-018907-c84t1bo5 111 4 ) ) -RRB- cord-018907-c84t1bo5 111 5 . . . cord-018907-c84t1bo5 112 1 There there EX cord-018907-c84t1bo5 112 2 is be VBZ cord-018907-c84t1bo5 112 3 no no DT cord-018907-c84t1bo5 112 4 ideal ideal JJ cord-018907-c84t1bo5 112 5 regimen regimen NN cord-018907-c84t1bo5 112 6 because because IN cord-018907-c84t1bo5 112 7 there there EX cord-018907-c84t1bo5 112 8 are be VBP cord-018907-c84t1bo5 112 9 variables variable NNS cord-018907-c84t1bo5 112 10 which which WDT cord-018907-c84t1bo5 112 11 include include VBP cord-018907-c84t1bo5 112 12 the the DT cord-018907-c84t1bo5 112 13 risk risk NN cord-018907-c84t1bo5 112 14 status status NN cord-018907-c84t1bo5 112 15 of of IN cord-018907-c84t1bo5 112 16 the the DT cord-018907-c84t1bo5 112 17 patient patient NN cord-018907-c84t1bo5 112 18 , , , cord-018907-c84t1bo5 112 19 microflora microflora NN cord-018907-c84t1bo5 112 20 and and CC cord-018907-c84t1bo5 112 21 their -PRON- PRP$ cord-018907-c84t1bo5 112 22 sensitivity sensitivity NN cord-018907-c84t1bo5 112 23 patterns pattern NNS cord-018907-c84t1bo5 112 24 , , , cord-018907-c84t1bo5 112 25 toxicity toxicity NN cord-018907-c84t1bo5 112 26 indication indication NN cord-018907-c84t1bo5 112 27 , , , cord-018907-c84t1bo5 112 28 preference preference NN cord-018907-c84t1bo5 112 29 , , , cord-018907-c84t1bo5 112 30 and and CC cord-018907-c84t1bo5 112 31 the the DT cord-018907-c84t1bo5 112 32 cost cost NN cord-018907-c84t1bo5 112 33 . . . cord-018907-c84t1bo5 113 1 Prompt prompt JJ cord-018907-c84t1bo5 113 2 initiation initiation NN cord-018907-c84t1bo5 113 3 of of IN cord-018907-c84t1bo5 113 4 broad broad JJ cord-018907-c84t1bo5 113 5 - - HYPH cord-018907-c84t1bo5 113 6 spectrum spectrum NN cord-018907-c84t1bo5 113 7 therapy therapy NN cord-018907-c84t1bo5 113 8 when when WRB cord-018907-c84t1bo5 113 9 neutropenic neutropenic JJ cord-018907-c84t1bo5 113 10 patients patient NNS cord-018907-c84t1bo5 113 11 became become VBD cord-018907-c84t1bo5 113 12 febrile febrile JJ cord-018907-c84t1bo5 113 13 is be VBZ cord-018907-c84t1bo5 113 14 the the DT cord-018907-c84t1bo5 113 15 key key NN cord-018907-c84t1bo5 113 16 to to IN cord-018907-c84t1bo5 113 17 successful successful JJ cord-018907-c84t1bo5 113 18 management management NN cord-018907-c84t1bo5 113 19 . . . cord-018907-c84t1bo5 114 1 In in IN cord-018907-c84t1bo5 114 2 1960 1960 CD cord-018907-c84t1bo5 114 3 the the DT cord-018907-c84t1bo5 114 4 mortality mortality NN cord-018907-c84t1bo5 114 5 rate rate NN cord-018907-c84t1bo5 114 6 was be VBD cord-018907-c84t1bo5 114 7 up up RB cord-018907-c84t1bo5 114 8 to to TO cord-018907-c84t1bo5 114 9 80 80 CD cord-018907-c84t1bo5 114 10 % % NN cord-018907-c84t1bo5 114 11 initially initially RB cord-018907-c84t1bo5 114 12 but but CC cord-018907-c84t1bo5 114 13 with with IN cord-018907-c84t1bo5 114 14 the the DT cord-018907-c84t1bo5 114 15 introduction introduction NN cord-018907-c84t1bo5 114 16 of of IN cord-018907-c84t1bo5 114 17 empiric empiric JJ cord-018907-c84t1bo5 114 18 therapy therapy NN cord-018907-c84t1bo5 114 19 against against IN cord-018907-c84t1bo5 114 20 gram gram NN cord-018907-c84t1bo5 114 21 - - HYPH cord-018907-c84t1bo5 114 22 negative negative JJ cord-018907-c84t1bo5 114 23 organism organism NN cord-018907-c84t1bo5 115 1 the the DT cord-018907-c84t1bo5 115 2 mortality mortality NN cord-018907-c84t1bo5 115 3 rate rate NN cord-018907-c84t1bo5 115 4 now now RB cord-018907-c84t1bo5 115 5 is be VBZ cord-018907-c84t1bo5 115 6 close close JJ cord-018907-c84t1bo5 115 7 to to IN cord-018907-c84t1bo5 115 8 5 5 CD cord-018907-c84t1bo5 115 9 % % NN cord-018907-c84t1bo5 115 10 . . . cord-018907-c84t1bo5 116 1 There there EX cord-018907-c84t1bo5 116 2 is be VBZ cord-018907-c84t1bo5 116 3 no no DT cord-018907-c84t1bo5 116 4 ideal ideal JJ cord-018907-c84t1bo5 116 5 regimen regimen NN cord-018907-c84t1bo5 116 6 because because IN cord-018907-c84t1bo5 116 7 this this DT cord-018907-c84t1bo5 116 8 can can MD cord-018907-c84t1bo5 116 9 be be VB cord-018907-c84t1bo5 116 10 determined determine VBN cord-018907-c84t1bo5 116 11 based base VBN cord-018907-c84t1bo5 116 12 on on IN cord-018907-c84t1bo5 116 13 the the DT cord-018907-c84t1bo5 116 14 isolate isolate NN cord-018907-c84t1bo5 116 15 and and CC cord-018907-c84t1bo5 116 16 its -PRON- PRP$ cord-018907-c84t1bo5 116 17 susceptibility susceptibility NN cord-018907-c84t1bo5 116 18 in in IN cord-018907-c84t1bo5 116 19 the the DT cord-018907-c84t1bo5 116 20 same same JJ cord-018907-c84t1bo5 116 21 center center NN cord-018907-c84t1bo5 116 22 as as IN cord-018907-c84t1bo5 116 23 each each DT cord-018907-c84t1bo5 116 24 center center NN cord-018907-c84t1bo5 116 25 for for IN cord-018907-c84t1bo5 116 26 example example NN cord-018907-c84t1bo5 116 27 , , , cord-018907-c84t1bo5 116 28 one one PRP cord-018907-c84t1bo5 116 29 can can MD cord-018907-c84t1bo5 116 30 not not RB cord-018907-c84t1bo5 116 31 extrapolate extrapolate VB cord-018907-c84t1bo5 116 32 from from IN cord-018907-c84t1bo5 116 33 different different JJ cord-018907-c84t1bo5 116 34 centers center NNS cord-018907-c84t1bo5 116 35 the the DT cord-018907-c84t1bo5 116 36 likely likely JJ cord-018907-c84t1bo5 116 37 pathogen pathogen NN cord-018907-c84t1bo5 116 38 , , , cord-018907-c84t1bo5 116 39 the the DT cord-018907-c84t1bo5 116 40 same same JJ cord-018907-c84t1bo5 116 41 thing thing NN cord-018907-c84t1bo5 116 42 that that WDT cord-018907-c84t1bo5 116 43 a a DT cord-018907-c84t1bo5 116 44 center center NN cord-018907-c84t1bo5 116 45 can can MD cord-018907-c84t1bo5 116 46 have have VB cord-018907-c84t1bo5 116 47 a a DT cord-018907-c84t1bo5 116 48 different different JJ cord-018907-c84t1bo5 116 49 pathogen pathogen NN cord-018907-c84t1bo5 116 50 and and CC cord-018907-c84t1bo5 116 51 different different JJ cord-018907-c84t1bo5 116 52 susceptibility susceptibility NN cord-018907-c84t1bo5 116 53 pattern pattern NN cord-018907-c84t1bo5 116 54 in in IN cord-018907-c84t1bo5 116 55 adult adult NN cord-018907-c84t1bo5 116 56 versus versus IN cord-018907-c84t1bo5 116 57 pediatric pediatric JJ cord-018907-c84t1bo5 116 58 population population NN cord-018907-c84t1bo5 116 59 with with IN cord-018907-c84t1bo5 116 60 febrile febrile JJ cord-018907-c84t1bo5 116 61 neutropenia neutropenia NN cord-018907-c84t1bo5 117 1 ( ( -LRB- cord-018907-c84t1bo5 117 2 > > XX cord-018907-c84t1bo5 117 3 Table table NN cord-018907-c84t1bo5 117 4 68 68 CD cord-018907-c84t1bo5 117 5 .2 .2 CD cord-018907-c84t1bo5 117 6 ) ) -RRB- cord-018907-c84t1bo5 117 7 . . . cord-018907-c84t1bo5 118 1 Monotherapy Monotherapy NNP cord-018907-c84t1bo5 118 2 and and CC cord-018907-c84t1bo5 118 3 combination combination NN cord-018907-c84t1bo5 118 4 therapy therapy NN cord-018907-c84t1bo5 118 5 has have VBZ cord-018907-c84t1bo5 118 6 equal equal JJ cord-018907-c84t1bo5 118 7 efficacy efficacy NN cord-018907-c84t1bo5 118 8 . . . cord-018907-c84t1bo5 119 1 The the DT cord-018907-c84t1bo5 119 2 monotherapy monotherapy NN cord-018907-c84t1bo5 119 3 needs need VBZ cord-018907-c84t1bo5 119 4 to to TO cord-018907-c84t1bo5 119 5 have have VB cord-018907-c84t1bo5 119 6 antipseudomonal antipseudomonal JJ cord-018907-c84t1bo5 119 7 activities activity NNS cord-018907-c84t1bo5 119 8 including include VBG cord-018907-c84t1bo5 119 9 antipseudomonal antipseudomonal JJ cord-018907-c84t1bo5 119 10 penicillin penicillin NN cord-018907-c84t1bo5 119 11 with with IN cord-018907-c84t1bo5 119 12 or or CC cord-018907-c84t1bo5 119 13 without without IN cord-018907-c84t1bo5 119 14 beta beta NN cord-018907-c84t1bo5 119 15 - - HYPH cord-018907-c84t1bo5 119 16 lactamase lactamase NN cord-018907-c84t1bo5 119 17 inhibitor inhibitor NN cord-018907-c84t1bo5 119 18 , , , cord-018907-c84t1bo5 119 19 carbapenem carbapenem NNP cord-018907-c84t1bo5 119 20 , , , cord-018907-c84t1bo5 119 21 and and CC cord-018907-c84t1bo5 119 22 third third JJ cord-018907-c84t1bo5 119 23 - - HYPH cord-018907-c84t1bo5 119 24 or or CC cord-018907-c84t1bo5 119 25 fourth fourth JJ cord-018907-c84t1bo5 119 26 - - HYPH cord-018907-c84t1bo5 119 27 generation generation NN cord-018907-c84t1bo5 119 28 antipseudomonal antipseudomonal JJ cord-018907-c84t1bo5 119 29 cephalosporins cephalosporin NNS cord-018907-c84t1bo5 119 30 . . . cord-018907-c84t1bo5 120 1 The the DT cord-018907-c84t1bo5 120 2 combination combination NN cord-018907-c84t1bo5 120 3 therapy therapy NN cord-018907-c84t1bo5 120 4 includes include VBZ cord-018907-c84t1bo5 120 5 antipseudomonal antipseudomonal JJ cord-018907-c84t1bo5 120 6 betalactam betalactam NNP cord-018907-c84t1bo5 120 7 with with IN cord-018907-c84t1bo5 120 8 Aminoglycoside Aminoglycoside NNP cord-018907-c84t1bo5 120 9 . . . cord-018907-c84t1bo5 121 1 Both both CC cord-018907-c84t1bo5 121 2 monotherapy monotherapy NN cord-018907-c84t1bo5 121 3 and and CC cord-018907-c84t1bo5 121 4 combination combination NN cord-018907-c84t1bo5 121 5 therapy therapy NN cord-018907-c84t1bo5 121 6 have have VBP cord-018907-c84t1bo5 121 7 equal equal JJ cord-018907-c84t1bo5 121 8 efficacy efficacy NN cord-018907-c84t1bo5 121 9 but but CC cord-018907-c84t1bo5 121 10 it -PRON- PRP cord-018907-c84t1bo5 121 11 is be VBZ cord-018907-c84t1bo5 121 12 important important JJ cord-018907-c84t1bo5 121 13 to to TO cord-018907-c84t1bo5 121 14 look look VB cord-018907-c84t1bo5 121 15 at at IN cord-018907-c84t1bo5 121 16 the the DT cord-018907-c84t1bo5 121 17 local local JJ cord-018907-c84t1bo5 121 18 data datum NNS cord-018907-c84t1bo5 121 19 to to TO cord-018907-c84t1bo5 121 20 be be VB cord-018907-c84t1bo5 121 21 able able JJ cord-018907-c84t1bo5 121 22 to to TO cord-018907-c84t1bo5 121 23 predict predict VB cord-018907-c84t1bo5 121 24 the the DT cord-018907-c84t1bo5 121 25 empiric empiric JJ cord-018907-c84t1bo5 121 26 therapy therapy NN cord-018907-c84t1bo5 121 27 either either CC cord-018907-c84t1bo5 121 28 combination combination NN cord-018907-c84t1bo5 121 29 therapy therapy NN cord-018907-c84t1bo5 121 30 or or CC cord-018907-c84t1bo5 121 31 monotherapy monotherapy NN cord-018907-c84t1bo5 121 32 . . . cord-018907-c84t1bo5 122 1 It -PRON- PRP cord-018907-c84t1bo5 122 2 is be VBZ cord-018907-c84t1bo5 122 3 worth worth JJ cord-018907-c84t1bo5 122 4 stressing stress VBG cord-018907-c84t1bo5 122 5 that that IN cord-018907-c84t1bo5 122 6 vancomycin vancomycin NN cord-018907-c84t1bo5 122 7 should should MD cord-018907-c84t1bo5 122 8 not not RB cord-018907-c84t1bo5 122 9 be be VB cord-018907-c84t1bo5 122 10 used use VBN cord-018907-c84t1bo5 122 11 routinely routinely RB cord-018907-c84t1bo5 122 12 for for IN cord-018907-c84t1bo5 122 13 empiric empiric JJ cord-018907-c84t1bo5 122 14 therapy therapy NN cord-018907-c84t1bo5 122 15 in in IN cord-018907-c84t1bo5 122 16 febrile febrile JJ cord-018907-c84t1bo5 122 17 neutropenia neutropenia NN cord-018907-c84t1bo5 122 18 and and CC cord-018907-c84t1bo5 122 19 there there EX cord-018907-c84t1bo5 122 20 is be VBZ cord-018907-c84t1bo5 122 21 a a DT cord-018907-c84t1bo5 122 22 special special JJ cord-018907-c84t1bo5 122 23 indication indication NN cord-018907-c84t1bo5 122 24 for for IN cord-018907-c84t1bo5 122 25 vancomycin vancomycin NN cord-018907-c84t1bo5 122 26 . . . cord-018907-c84t1bo5 123 1 The the DT cord-018907-c84t1bo5 123 2 vancomycin vancomycin NN cord-018907-c84t1bo5 123 3 indication indication NN cord-018907-c84t1bo5 123 4 includes include VBZ cord-018907-c84t1bo5 123 5 hemodynamic hemodynamic JJ cord-018907-c84t1bo5 123 6 instability instability NN cord-018907-c84t1bo5 123 7 or or CC cord-018907-c84t1bo5 123 8 other other JJ cord-018907-c84t1bo5 123 9 evidence evidence NN cord-018907-c84t1bo5 123 10 of of IN cord-018907-c84t1bo5 123 11 severe severe JJ cord-018907-c84t1bo5 123 12 sepsis sepsis NN cord-018907-c84t1bo5 123 13 , , , cord-018907-c84t1bo5 123 14 pneumonia pneumonia NN cord-018907-c84t1bo5 123 15 documented document VBD cord-018907-c84t1bo5 123 16 radiographically radiographically RB cord-018907-c84t1bo5 123 17 , , , cord-018907-c84t1bo5 123 18 positive positive JJ cord-018907-c84t1bo5 123 19 blood blood NN cord-018907-c84t1bo5 123 20 culture culture NN cord-018907-c84t1bo5 123 21 for for IN cord-018907-c84t1bo5 123 22 gram gram NN cord-018907-c84t1bo5 123 23 - - HYPH cord-018907-c84t1bo5 123 24 positive positive JJ cord-018907-c84t1bo5 123 25 bacteria bacteria NNS cord-018907-c84t1bo5 123 26 before before IN cord-018907-c84t1bo5 123 27 final final JJ cord-018907-c84t1bo5 123 28 identification identification NN cord-018907-c84t1bo5 123 29 and and CC cord-018907-c84t1bo5 123 30 susceptibility susceptibility NN cord-018907-c84t1bo5 123 31 testing testing NN cord-018907-c84t1bo5 123 32 is be VBZ cord-018907-c84t1bo5 123 33 available available JJ cord-018907-c84t1bo5 123 34 , , , cord-018907-c84t1bo5 123 35 clinically clinically RB cord-018907-c84t1bo5 123 36 suspected suspect VBN cord-018907-c84t1bo5 123 37 catheter catheter NN cord-018907-c84t1bo5 123 38 - - HYPH cord-018907-c84t1bo5 123 39 related relate VBN cord-018907-c84t1bo5 123 40 infections infection NNS cord-018907-c84t1bo5 123 41 ( ( -LRB- cord-018907-c84t1bo5 123 42 e. e. NNP cord-018907-c84t1bo5 123 43 g. g. NNP cord-018907-c84t1bo5 123 44 , , , cord-018907-c84t1bo5 124 1 chills chill NNS cord-018907-c84t1bo5 124 2 or or CC cord-018907-c84t1bo5 124 3 rigors rigor NNS cord-018907-c84t1bo5 124 4 with with IN cord-018907-c84t1bo5 124 5 infusion infusion NN cord-018907-c84t1bo5 124 6 through through IN cord-018907-c84t1bo5 124 7 catheter catheter NN cord-018907-c84t1bo5 124 8 and and CC cord-018907-c84t1bo5 124 9 cellulitis cellulitis NN cord-018907-c84t1bo5 124 10 around around IN cord-018907-c84t1bo5 124 11 the the DT cord-018907-c84t1bo5 124 12 catheter catheter NN cord-018907-c84t1bo5 124 13 entry entry NN cord-018907-c84t1bo5 124 14 / / SYM cord-018907-c84t1bo5 124 15 exit exit NN cord-018907-c84t1bo5 124 16 site site NN cord-018907-c84t1bo5 124 17 ) ) -RRB- cord-018907-c84t1bo5 124 18 , , , cord-018907-c84t1bo5 124 19 skin skin NN cord-018907-c84t1bo5 124 20 or or CC cord-018907-c84t1bo5 124 21 soft soft JJ cord-018907-c84t1bo5 124 22 - - HYPH cord-018907-c84t1bo5 124 23 tissue tissue NN cord-018907-c84t1bo5 124 24 infection infection NN cord-018907-c84t1bo5 124 25 at at IN cord-018907-c84t1bo5 124 26 any any DT cord-018907-c84t1bo5 124 27 site site NN cord-018907-c84t1bo5 124 28 , , , cord-018907-c84t1bo5 124 29 colonization colonization NN cord-018907-c84t1bo5 124 30 with with IN cord-018907-c84t1bo5 124 31 methicillin methicillin NN cord-018907-c84t1bo5 124 32 - - HYPH cord-018907-c84t1bo5 124 33 resistant resistant JJ cord-018907-c84t1bo5 124 34 Staphylococcus Staphylococcus NNP cord-018907-c84t1bo5 124 35 aureus aureus NN cord-018907-c84t1bo5 124 36 , , , cord-018907-c84t1bo5 124 37 vancomycin vancomycin NN cord-018907-c84t1bo5 124 38 - - HYPH cord-018907-c84t1bo5 124 39 resistant resistant JJ cord-018907-c84t1bo5 124 40 enterococcus enterococcus NN cord-018907-c84t1bo5 124 41 , , , cord-018907-c84t1bo5 124 42 or or CC cord-018907-c84t1bo5 124 43 penicillin penicillin NN cord-018907-c84t1bo5 124 44 - - HYPH cord-018907-c84t1bo5 124 45 resistant resistant JJ cord-018907-c84t1bo5 124 46 Streptococcus streptococcus NN cord-018907-c84t1bo5 124 47 pneumoniae pneumoniae NN cord-018907-c84t1bo5 124 48 , , , cord-018907-c84t1bo5 124 49 and and CC cord-018907-c84t1bo5 124 50 severe severe JJ cord-018907-c84t1bo5 124 51 mucositis mucositis NNP cord-018907-c84t1bo5 124 52 , , , cord-018907-c84t1bo5 124 53 if if IN cord-018907-c84t1bo5 124 54 fluoroquinolone fluoroquinolone NN cord-018907-c84t1bo5 124 55 prophylaxis prophylaxis NN cord-018907-c84t1bo5 124 56 has have VBZ cord-018907-c84t1bo5 124 57 been be VBN cord-018907-c84t1bo5 124 58 given give VBN cord-018907-c84t1bo5 124 59 and and CC cord-018907-c84t1bo5 124 60 ceftazidime ceftazidime NN cord-018907-c84t1bo5 124 61 is be VBZ cord-018907-c84t1bo5 124 62 employed employ VBN cord-018907-c84t1bo5 124 63 as as IN cord-018907-c84t1bo5 124 64 empirical empirical JJ cord-018907-c84t1bo5 124 65 therapy therapy NN cord-018907-c84t1bo5 124 66 . . . cord-018907-c84t1bo5 125 1 If if IN cord-018907-c84t1bo5 125 2 the the DT cord-018907-c84t1bo5 125 3 patient patient NN cord-018907-c84t1bo5 125 4 started start VBD cord-018907-c84t1bo5 125 5 empirically empirically RB cord-018907-c84t1bo5 125 6 on on IN cord-018907-c84t1bo5 125 7 vancomycin vancomycin FW cord-018907-c84t1bo5 125 8 the the DT cord-018907-c84t1bo5 125 9 need need NN cord-018907-c84t1bo5 125 10 for for IN cord-018907-c84t1bo5 125 11 continuation continuation NN cord-018907-c84t1bo5 125 12 of of IN cord-018907-c84t1bo5 125 13 vancomycin vancomycin NN cord-018907-c84t1bo5 125 14 should should MD cord-018907-c84t1bo5 125 15 be be VB cord-018907-c84t1bo5 125 16 re re VBN cord-018907-c84t1bo5 125 17 - - VBN cord-018907-c84t1bo5 125 18 assessed assess VBN cord-018907-c84t1bo5 125 19 on on IN cord-018907-c84t1bo5 125 20 daily daily JJ cord-018907-c84t1bo5 125 21 basis basis NN cord-018907-c84t1bo5 125 22 . . . cord-018907-c84t1bo5 126 1 Overuse overuse NN cord-018907-c84t1bo5 126 2 of of IN cord-018907-c84t1bo5 126 3 vancomycin vancomycin NN cord-018907-c84t1bo5 126 4 in in IN cord-018907-c84t1bo5 126 5 more more JJR cord-018907-c84t1bo5 126 6 than than IN cord-018907-c84t1bo5 126 7 90 90 CD cord-018907-c84t1bo5 126 8 % % NN cord-018907-c84t1bo5 126 9 , , , cord-018907-c84t1bo5 126 10 and and CC cord-018907-c84t1bo5 126 11 selection selection NN cord-018907-c84t1bo5 126 12 for for IN cord-018907-c84t1bo5 126 13 resistant resistant JJ cord-018907-c84t1bo5 126 14 organism organism NN cord-018907-c84t1bo5 126 15 and and CC cord-018907-c84t1bo5 126 16 emergence emergence NN cord-018907-c84t1bo5 126 17 of of IN cord-018907-c84t1bo5 126 18 vancomycin vancomycin NN cord-018907-c84t1bo5 126 19 resistance resistance NN cord-018907-c84t1bo5 126 20 enterococci enterococci NNP cord-018907-c84t1bo5 126 21 . . . cord-018907-c84t1bo5 127 1 The the DT cord-018907-c84t1bo5 127 2 factors factor NNS cord-018907-c84t1bo5 127 3 influencing influence VBG cord-018907-c84t1bo5 127 4 antimicrobial antimicrobial JJ cord-018907-c84t1bo5 127 5 selection selection NN cord-018907-c84t1bo5 127 6 include include VBP cord-018907-c84t1bo5 127 7 the the DT cord-018907-c84t1bo5 127 8 types type NNS cord-018907-c84t1bo5 127 9 of of IN cord-018907-c84t1bo5 127 10 bacterial bacterial JJ cord-018907-c84t1bo5 127 11 isolates isolate NNS cord-018907-c84t1bo5 127 12 found find VBN cord-018907-c84t1bo5 127 13 in in IN cord-018907-c84t1bo5 127 14 the the DT cord-018907-c84t1bo5 127 15 institution institution NN cord-018907-c84t1bo5 127 16 , , , cord-018907-c84t1bo5 127 17 antibiotic antibiotic JJ cord-018907-c84t1bo5 127 18 susceptibility susceptibility NN cord-018907-c84t1bo5 127 19 patterns pattern NNS cord-018907-c84t1bo5 127 20 , , , cord-018907-c84t1bo5 127 21 drug drug NN cord-018907-c84t1bo5 127 22 allergies allergy NNS cord-018907-c84t1bo5 127 23 , , , cord-018907-c84t1bo5 127 24 presence presence NN cord-018907-c84t1bo5 127 25 of of IN cord-018907-c84t1bo5 127 26 organ organ NN cord-018907-c84t1bo5 127 27 dysfunction dysfunction NN cord-018907-c84t1bo5 127 28 , , , cord-018907-c84t1bo5 127 29 chemotherapeutic chemotherapeutic JJ cord-018907-c84t1bo5 127 30 regimen regimen NN cord-018907-c84t1bo5 127 31 whether whether IN cord-018907-c84t1bo5 127 32 the the DT cord-018907-c84t1bo5 127 33 patient patient NN cord-018907-c84t1bo5 127 34 was be VBD cord-018907-c84t1bo5 127 35 receiving receive VBG cord-018907-c84t1bo5 127 36 prophylactic prophylactic JJ cord-018907-c84t1bo5 127 37 antibiotics antibiotic NNS cord-018907-c84t1bo5 127 38 , , , cord-018907-c84t1bo5 127 39 and and CC cord-018907-c84t1bo5 127 40 condition condition NN cord-018907-c84t1bo5 127 41 of of IN cord-018907-c84t1bo5 127 42 the the DT cord-018907-c84t1bo5 127 43 patient patient NN cord-018907-c84t1bo5 127 44 at at IN cord-018907-c84t1bo5 127 45 diagnosis diagnosis NN cord-018907-c84t1bo5 127 46 , , , cord-018907-c84t1bo5 127 47 for for IN cord-018907-c84t1bo5 127 48 example example NN cord-018907-c84t1bo5 127 49 , , , cord-018907-c84t1bo5 127 50 presence presence NN cord-018907-c84t1bo5 127 51 of of IN cord-018907-c84t1bo5 127 52 signs sign NNS cord-018907-c84t1bo5 127 53 and and CC cord-018907-c84t1bo5 127 54 symptoms symptom NNS cord-018907-c84t1bo5 127 55 at at IN cord-018907-c84t1bo5 127 56 initial initial JJ cord-018907-c84t1bo5 127 57 evaluation evaluation NN cord-018907-c84t1bo5 127 58 and and CC cord-018907-c84t1bo5 127 59 presence presence NN cord-018907-c84t1bo5 127 60 of of IN cord-018907-c84t1bo5 127 61 documented document VBN cord-018907-c84t1bo5 127 62 sites site NNS cord-018907-c84t1bo5 127 63 requiring require VBG cord-018907-c84t1bo5 127 64 additional additional JJ cord-018907-c84t1bo5 127 65 therapy therapy NN cord-018907-c84t1bo5 127 66 . . . cord-018907-c84t1bo5 128 1 The the DT cord-018907-c84t1bo5 128 2 center center NN cord-018907-c84t1bo5 128 3 - - HYPH cord-018907-c84t1bo5 128 4 specific specific JJ cord-018907-c84t1bo5 128 5 factors factor NNS cord-018907-c84t1bo5 128 6 include include VBP cord-018907-c84t1bo5 128 7 the the DT cord-018907-c84t1bo5 128 8 patterns pattern NNS cord-018907-c84t1bo5 128 9 of of IN cord-018907-c84t1bo5 128 10 resistance resistance NN cord-018907-c84t1bo5 128 11 , , , cord-018907-c84t1bo5 128 12 effect effect NN cord-018907-c84t1bo5 128 13 on on IN cord-018907-c84t1bo5 128 14 microbial microbial JJ cord-018907-c84t1bo5 128 15 ecology ecology NN cord-018907-c84t1bo5 128 16 , , , cord-018907-c84t1bo5 128 17 high high JJ cord-018907-c84t1bo5 128 18 presence presence NN cord-018907-c84t1bo5 128 19 of of IN cord-018907-c84t1bo5 128 20 vancomycin vancomycin NN cord-018907-c84t1bo5 128 21 resistance resistance NN cord-018907-c84t1bo5 128 22 enterococci enterococci NNP cord-018907-c84t1bo5 128 23 ( ( -LRB- cord-018907-c84t1bo5 128 24 VRE VRE NNP cord-018907-c84t1bo5 128 25 ) ) -RRB- cord-018907-c84t1bo5 128 26 , , , cord-018907-c84t1bo5 128 27 or or CC cord-018907-c84t1bo5 128 28 extended extend VBN cord-018907-c84t1bo5 128 29 spectrum spectrum NN cord-018907-c84t1bo5 128 30 beta beta NN cord-018907-c84t1bo5 128 31 - - HYPH cord-018907-c84t1bo5 128 32 lactamase lactamase NN cord-018907-c84t1bo5 128 33 ( ( -LRB- cord-018907-c84t1bo5 128 34 ESBL ESBL NNP cord-018907-c84t1bo5 128 35 ) ) -RRB- cord-018907-c84t1bo5 128 36 producing produce VBG cord-018907-c84t1bo5 128 37 organism organism NN cord-018907-c84t1bo5 128 38 . . . cord-018907-c84t1bo5 129 1 The the DT cord-018907-c84t1bo5 129 2 patient patient NN cord-018907-c84t1bo5 129 3 - - HYPH cord-018907-c84t1bo5 129 4 specific specific JJ cord-018907-c84t1bo5 129 5 factors factor NNS cord-018907-c84t1bo5 129 6 including include VBG cord-018907-c84t1bo5 129 7 recent recent JJ cord-018907-c84t1bo5 129 8 antibiotic antibiotic JJ cord-018907-c84t1bo5 129 9 use use NN cord-018907-c84t1bo5 129 10 such such JJ cord-018907-c84t1bo5 129 11 as as IN cord-018907-c84t1bo5 129 12 current current JJ cord-018907-c84t1bo5 129 13 prophylaxis prophylaxis NN cord-018907-c84t1bo5 129 14 as as IN cord-018907-c84t1bo5 129 15 drug drug NN cord-018907-c84t1bo5 129 16 allergy allergy NN cord-018907-c84t1bo5 129 17 , , , cord-018907-c84t1bo5 129 18 and and CC cord-018907-c84t1bo5 129 19 the the DT cord-018907-c84t1bo5 129 20 underlying underlying JJ cord-018907-c84t1bo5 129 21 organ organ NN cord-018907-c84t1bo5 129 22 dysfunction dysfunction NN cord-018907-c84t1bo5 129 23 . . . cord-018907-c84t1bo5 130 1 The the DT cord-018907-c84t1bo5 130 2 signs sign NNS cord-018907-c84t1bo5 130 3 and and CC cord-018907-c84t1bo5 130 4 symptoms symptom NNS cord-018907-c84t1bo5 130 5 present present JJ cord-018907-c84t1bo5 130 6 at at IN cord-018907-c84t1bo5 130 7 the the DT cord-018907-c84t1bo5 130 8 initial initial JJ cord-018907-c84t1bo5 130 9 evaluation evaluation NN cord-018907-c84t1bo5 130 10 determine determine NN cord-018907-c84t1bo5 130 11 . . . cord-018907-c84t1bo5 131 1 In in IN cord-018907-c84t1bo5 131 2 the the DT cord-018907-c84t1bo5 131 3 recent recent JJ cord-018907-c84t1bo5 131 4 year year NN cord-018907-c84t1bo5 131 5 more more JJR cord-018907-c84t1bo5 131 6 interest interest NN cord-018907-c84t1bo5 131 7 in in IN cord-018907-c84t1bo5 131 8 the the DT cord-018907-c84t1bo5 131 9 outpatient outpatient NN cord-018907-c84t1bo5 131 10 therapy therapy NN cord-018907-c84t1bo5 131 11 for for IN cord-018907-c84t1bo5 131 12 patient patient NN cord-018907-c84t1bo5 131 13 with with IN cord-018907-c84t1bo5 131 14 fever fever NN cord-018907-c84t1bo5 131 15 and and CC cord-018907-c84t1bo5 131 16 neutropenia neutropenia NN cord-018907-c84t1bo5 131 17 . . . cord-018907-c84t1bo5 132 1 The the DT cord-018907-c84t1bo5 132 2 advantages advantage NNS cord-018907-c84t1bo5 132 3 of of IN cord-018907-c84t1bo5 132 4 ambulatory ambulatory JJ cord-018907-c84t1bo5 132 5 management management NN cord-018907-c84t1bo5 132 6 of of IN cord-018907-c84t1bo5 132 7 febrile febrile JJ cord-018907-c84t1bo5 132 8 patients patient NNS cord-018907-c84t1bo5 132 9 with with IN cord-018907-c84t1bo5 132 10 neutropenia neutropenia NN cord-018907-c84t1bo5 132 11 especially especially RB cord-018907-c84t1bo5 132 12 those those DT cord-018907-c84t1bo5 132 13 at at IN cord-018907-c84t1bo5 132 14 low low JJ cord-018907-c84t1bo5 132 15 risk risk NN cord-018907-c84t1bo5 132 16 include include VBP cord-018907-c84t1bo5 132 17 lower low JJR cord-018907-c84t1bo5 132 18 cost cost NN cord-018907-c84t1bo5 132 19 particularly particularly RB cord-018907-c84t1bo5 132 20 with with IN cord-018907-c84t1bo5 132 21 oral oral JJ cord-018907-c84t1bo5 132 22 outpatient outpatient NN cord-018907-c84t1bo5 132 23 therapy therapy NN cord-018907-c84t1bo5 132 24 , , , cord-018907-c84t1bo5 132 25 fewer few JJR cord-018907-c84t1bo5 132 26 superinfections superinfection NNS cord-018907-c84t1bo5 132 27 caused cause VBN cord-018907-c84t1bo5 132 28 by by IN cord-018907-c84t1bo5 132 29 multidrug multidrug NN cord-018907-c84t1bo5 132 30 - - HYPH cord-018907-c84t1bo5 132 31 resistant resistant JJ cord-018907-c84t1bo5 132 32 nosocomial nosocomial JJ cord-018907-c84t1bo5 132 33 pathogens pathogen NNS cord-018907-c84t1bo5 132 34 , , , cord-018907-c84t1bo5 132 35 improved improve VBN cord-018907-c84t1bo5 132 36 quality quality NN cord-018907-c84t1bo5 132 37 of of IN cord-018907-c84t1bo5 132 38 life life NN cord-018907-c84t1bo5 132 39 for for IN cord-018907-c84t1bo5 132 40 patient patient NN cord-018907-c84t1bo5 132 41 , , , cord-018907-c84t1bo5 132 42 greater great JJR cord-018907-c84t1bo5 132 43 . . . cord-018907-c84t1bo5 133 1 Not not RB cord-018907-c84t1bo5 133 2 recommended recommend VBN cord-018907-c84t1bo5 133 3 for for IN cord-018907-c84t1bo5 133 4 routine routine JJ cord-018907-c84t1bo5 133 5 use use NN cord-018907-c84t1bo5 133 6 * * NFP cord-018907-c84t1bo5 134 1 Other other JJ cord-018907-c84t1bo5 134 2 antimicrobials antimicrobial NNS cord-018907-c84t1bo5 134 3 ( ( -LRB- cord-018907-c84t1bo5 134 4 aminoglycosides aminoglycoside NNS cord-018907-c84t1bo5 134 5 , , , cord-018907-c84t1bo5 134 6 fluoropuinolone fluoropuinolone NNP cord-018907-c84t1bo5 134 7 , , , cord-018907-c84t1bo5 134 8 and/or and/or CC cord-018907-c84t1bo5 134 9 vancomycin vancomycin NN cord-018907-c84t1bo5 134 10 ) ) -RRB- cord-018907-c84t1bo5 134 11 may may MD cord-018907-c84t1bo5 134 12 be be VB cord-018907-c84t1bo5 134 13 added add VBN cord-018907-c84t1bo5 134 14 to to IN cord-018907-c84t1bo5 134 15 initial initial JJ cord-018907-c84t1bo5 134 16 regimen regimen NN cord-018907-c84t1bo5 134 17 for for IN cord-018907-c84t1bo5 134 18 complicated complicated JJ cord-018907-c84t1bo5 134 19 presentation presentation NN cord-018907-c84t1bo5 134 20 or or CC cord-018907-c84t1bo5 134 21 if if IN cord-018907-c84t1bo5 134 22 resistance resistance NN cord-018907-c84t1bo5 134 23 is be VBZ cord-018907-c84t1bo5 134 24 suspected suspect VBN cord-018907-c84t1bo5 134 25 or or CC cord-018907-c84t1bo5 134 26 proven prove VBN cord-018907-c84t1bo5 134 27 Infections infection NNS cord-018907-c84t1bo5 134 28 in in IN cord-018907-c84t1bo5 134 29 the the DT cord-018907-c84t1bo5 134 30 Immunocompromised Immunocompromised NNP cord-018907-c84t1bo5 134 31 Host Host NNP cord-018907-c84t1bo5 134 32 convenience convenience NN cord-018907-c84t1bo5 134 33 for for IN cord-018907-c84t1bo5 134 34 family family NN cord-018907-c84t1bo5 134 35 or or CC cord-018907-c84t1bo5 134 36 other other JJ cord-018907-c84t1bo5 134 37 caregivers caregiver NNS cord-018907-c84t1bo5 134 38 , , , cord-018907-c84t1bo5 134 39 and and CC cord-018907-c84t1bo5 134 40 more more RBR cord-018907-c84t1bo5 134 41 efficient efficient JJ cord-018907-c84t1bo5 134 42 utilization utilization NN cord-018907-c84t1bo5 134 43 of of IN cord-018907-c84t1bo5 134 44 valuable valuable JJ cord-018907-c84t1bo5 134 45 and and CC cord-018907-c84t1bo5 134 46 expensive expensive JJ cord-018907-c84t1bo5 134 47 resources resource NNS cord-018907-c84t1bo5 134 48 . . . cord-018907-c84t1bo5 135 1 The the DT cord-018907-c84t1bo5 135 2 disadvantage disadvantage NN cord-018907-c84t1bo5 135 3 includes include VBZ cord-018907-c84t1bo5 135 4 the the DT cord-018907-c84t1bo5 135 5 potential potential JJ cord-018907-c84t1bo5 135 6 risk risk NN cord-018907-c84t1bo5 135 7 for for IN cord-018907-c84t1bo5 135 8 developing develop VBG cord-018907-c84t1bo5 135 9 serious serious JJ cord-018907-c84t1bo5 135 10 complications complication NNS cord-018907-c84t1bo5 135 11 such such JJ cord-018907-c84t1bo5 135 12 as as IN cord-018907-c84t1bo5 135 13 septic septic JJ cord-018907-c84t1bo5 135 14 shock shock NN cord-018907-c84t1bo5 135 15 at at IN cord-018907-c84t1bo5 135 16 home home NN cord-018907-c84t1bo5 135 17 , , , cord-018907-c84t1bo5 135 18 risk risk NN cord-018907-c84t1bo5 135 19 of of IN cord-018907-c84t1bo5 135 20 noncompliance noncompliance NN cord-018907-c84t1bo5 135 21 particularly particularly RB cord-018907-c84t1bo5 135 22 with with IN cord-018907-c84t1bo5 135 23 oral oral JJ cord-018907-c84t1bo5 135 24 therapy therapy NN cord-018907-c84t1bo5 135 25 , , , cord-018907-c84t1bo5 135 26 false false JJ cord-018907-c84t1bo5 135 27 sense sense NN cord-018907-c84t1bo5 135 28 of of IN cord-018907-c84t1bo5 135 29 security security NN cord-018907-c84t1bo5 135 30 or or CC cord-018907-c84t1bo5 135 31 inadequate inadequate JJ cord-018907-c84t1bo5 135 32 monitoring monitoring NN cord-018907-c84t1bo5 135 33 for for IN cord-018907-c84t1bo5 135 34 response response NN cord-018907-c84t1bo5 135 35 to to IN cord-018907-c84t1bo5 135 36 therapy therapy NN cord-018907-c84t1bo5 135 37 or or CC cord-018907-c84t1bo5 135 38 toxicity toxicity NN cord-018907-c84t1bo5 135 39 , , , cord-018907-c84t1bo5 135 40 and and CC cord-018907-c84t1bo5 135 41 the the DT cord-018907-c84t1bo5 135 42 need need NN cord-018907-c84t1bo5 135 43 to to TO cord-018907-c84t1bo5 135 44 develop develop VB cord-018907-c84t1bo5 135 45 a a DT cord-018907-c84t1bo5 135 46 team team NN cord-018907-c84t1bo5 135 47 and and CC cord-018907-c84t1bo5 135 48 infrastructure infrastructure NN cord-018907-c84t1bo5 135 49 capable capable JJ cord-018907-c84t1bo5 135 50 of of IN cord-018907-c84t1bo5 135 51 treating treat VBG cord-018907-c84t1bo5 135 52 substantial substantial JJ cord-018907-c84t1bo5 135 53 numbers number NNS cord-018907-c84t1bo5 135 54 of of IN cord-018907-c84t1bo5 135 55 low low JJ cord-018907-c84t1bo5 135 56 - - HYPH cord-018907-c84t1bo5 135 57 risk risk NN cord-018907-c84t1bo5 135 58 patients patient NNS cord-018907-c84t1bo5 135 59 . . . cord-018907-c84t1bo5 136 1 There there EX cord-018907-c84t1bo5 136 2 are be VBP cord-018907-c84t1bo5 136 3 several several JJ cord-018907-c84t1bo5 136 4 requirements requirement NNS cord-018907-c84t1bo5 136 5 for for IN cord-018907-c84t1bo5 136 6 successful successful JJ cord-018907-c84t1bo5 136 7 outpatient outpatient NN cord-018907-c84t1bo5 136 8 treatment treatment NN cord-018907-c84t1bo5 136 9 programs program NNS cord-018907-c84t1bo5 136 10 for for IN cord-018907-c84t1bo5 136 11 patients patient NNS cord-018907-c84t1bo5 136 12 with with IN cord-018907-c84t1bo5 136 13 febrile febrile JJ cord-018907-c84t1bo5 136 14 neutropenia neutropenia NN cord-018907-c84t1bo5 136 15 which which WDT cord-018907-c84t1bo5 136 16 include include VBP cord-018907-c84t1bo5 136 17 institutional institutional JJ cord-018907-c84t1bo5 136 18 infrastructure infrastructure NN cord-018907-c84t1bo5 136 19 and and CC cord-018907-c84t1bo5 136 20 support support NN cord-018907-c84t1bo5 136 21 , , , cord-018907-c84t1bo5 136 22 a a DT cord-018907-c84t1bo5 136 23 dedicated dedicated JJ cord-018907-c84t1bo5 136 24 and and CC cord-018907-c84t1bo5 136 25 experienced experienced JJ cord-018907-c84t1bo5 136 26 team team NN cord-018907-c84t1bo5 136 27 of of IN cord-018907-c84t1bo5 136 28 healthcare healthcare NN cord-018907-c84t1bo5 136 29 providers provider NNS cord-018907-c84t1bo5 136 30 , , , cord-018907-c84t1bo5 136 31 availability availability NN cord-018907-c84t1bo5 136 32 of of IN cord-018907-c84t1bo5 136 33 institution institution NN cord-018907-c84t1bo5 136 34 - - HYPH cord-018907-c84t1bo5 136 35 specific specific JJ cord-018907-c84t1bo5 136 36 epidemiological epidemiological JJ cord-018907-c84t1bo5 136 37 data datum NNS cord-018907-c84t1bo5 136 38 and and CC cord-018907-c84t1bo5 136 39 susceptibility susceptibility NN cord-018907-c84t1bo5 136 40 and and CC cord-018907-c84t1bo5 136 41 resistance resistance NN cord-018907-c84t1bo5 136 42 data datum NNS cord-018907-c84t1bo5 136 43 , , , cord-018907-c84t1bo5 136 44 microbiologically microbiologically RB cord-018907-c84t1bo5 136 45 appropriate appropriate JJ cord-018907-c84t1bo5 136 46 treatment treatment NN cord-018907-c84t1bo5 136 47 regimen regimen NN cord-018907-c84t1bo5 136 48 , , , cord-018907-c84t1bo5 136 49 frequent frequent JJ cord-018907-c84t1bo5 136 50 follow follow NN cord-018907-c84t1bo5 136 51 - - HYPH cord-018907-c84t1bo5 136 52 up up NN cord-018907-c84t1bo5 136 53 monitoring monitoring NN cord-018907-c84t1bo5 136 54 of of IN cord-018907-c84t1bo5 136 55 outpatient outpatient NN cord-018907-c84t1bo5 136 56 , , , cord-018907-c84t1bo5 136 57 adequate adequate JJ cord-018907-c84t1bo5 136 58 transportation transportation NN cord-018907-c84t1bo5 136 59 and and CC cord-018907-c84t1bo5 136 60 communication communication NN cord-018907-c84t1bo5 136 61 capabilities capability NNS cord-018907-c84t1bo5 136 62 , , , cord-018907-c84t1bo5 136 63 and and CC cord-018907-c84t1bo5 136 64 access access NN cord-018907-c84t1bo5 136 65 to to IN cord-018907-c84t1bo5 136 66 management management NN cord-018907-c84t1bo5 136 67 team team NN cord-018907-c84t1bo5 136 68 24 24 CD cord-018907-c84t1bo5 136 69 h h NN cord-018907-c84t1bo5 136 70 a a DT cord-018907-c84t1bo5 136 71 day day NN cord-018907-c84t1bo5 136 72 , , , cord-018907-c84t1bo5 136 73 7 7 CD cord-018907-c84t1bo5 136 74 days day NNS cord-018907-c84t1bo5 136 75 a a DT cord-018907-c84t1bo5 136 76 week week NN cord-018907-c84t1bo5 136 77 . . . cord-018907-c84t1bo5 137 1 There there EX cord-018907-c84t1bo5 137 2 are be VBP cord-018907-c84t1bo5 137 3 certain certain JJ cord-018907-c84t1bo5 137 4 clinical clinical JJ cord-018907-c84t1bo5 137 5 events event NNS cord-018907-c84t1bo5 137 6 or or CC cord-018907-c84t1bo5 137 7 manifestations manifestation NNS cord-018907-c84t1bo5 137 8 that that WDT cord-018907-c84t1bo5 137 9 require require VBP cord-018907-c84t1bo5 137 10 modifying modify VBG cord-018907-c84t1bo5 137 11 the the DT cord-018907-c84t1bo5 137 12 initial initial JJ cord-018907-c84t1bo5 137 13 antimicrobial antimicrobial JJ cord-018907-c84t1bo5 137 14 therapy therapy NN cord-018907-c84t1bo5 137 15 ; ; : cord-018907-c84t1bo5 137 16 for for IN cord-018907-c84t1bo5 137 17 example example NN cord-018907-c84t1bo5 137 18 , , , cord-018907-c84t1bo5 137 19 if if IN cord-018907-c84t1bo5 137 20 a a DT cord-018907-c84t1bo5 137 21 patient patient NN cord-018907-c84t1bo5 137 22 has have VBZ cord-018907-c84t1bo5 137 23 breakthrough breakthrough JJ cord-018907-c84t1bo5 137 24 bacteremia bacteremia NN cord-018907-c84t1bo5 137 25 and and CC cord-018907-c84t1bo5 137 26 if if IN cord-018907-c84t1bo5 137 27 Gram gram NN cord-018907-c84t1bo5 137 28 - - HYPH cord-018907-c84t1bo5 137 29 positive positive JJ cord-018907-c84t1bo5 137 30 is be VBZ cord-018907-c84t1bo5 137 31 isolated isolate VBN cord-018907-c84t1bo5 137 32 ( ( -LRB- cord-018907-c84t1bo5 137 33 add add VB cord-018907-c84t1bo5 137 34 vancomycin vancomycin NN cord-018907-c84t1bo5 137 35 especially especially RB cord-018907-c84t1bo5 137 36 if if IN cord-018907-c84t1bo5 137 37 there there EX cord-018907-c84t1bo5 137 38 is be VBZ cord-018907-c84t1bo5 137 39 a a DT cord-018907-c84t1bo5 137 40 risk risk NN cord-018907-c84t1bo5 137 41 of of IN cord-018907-c84t1bo5 137 42 MRSA MRSA NNP cord-018907-c84t1bo5 137 43 or or CC cord-018907-c84t1bo5 137 44 pneumococcal pneumococcal JJ cord-018907-c84t1bo5 137 45 resistance resistance NN cord-018907-c84t1bo5 137 46 penicillin penicillin NN cord-018907-c84t1bo5 137 47 ) ) -RRB- cord-018907-c84t1bo5 137 48 . . . cord-018907-c84t1bo5 138 1 If if IN cord-018907-c84t1bo5 138 2 Gram gram NN cord-018907-c84t1bo5 138 3 - - HYPH cord-018907-c84t1bo5 138 4 negative negative JJ cord-018907-c84t1bo5 138 5 organism organism NN cord-018907-c84t1bo5 138 6 is be VBZ cord-018907-c84t1bo5 138 7 isolated isolate VBN cord-018907-c84t1bo5 138 8 consider consider VBP cord-018907-c84t1bo5 138 9 resistant resistant JJ cord-018907-c84t1bo5 138 10 Gram gram NN cord-018907-c84t1bo5 138 11 - - HYPH cord-018907-c84t1bo5 138 12 negative negative JJ cord-018907-c84t1bo5 138 13 and and CC cord-018907-c84t1bo5 138 14 can can MD cord-018907-c84t1bo5 138 15 change change VB cord-018907-c84t1bo5 138 16 the the DT cord-018907-c84t1bo5 138 17 regimen regimen NN cord-018907-c84t1bo5 138 18 or or CC cord-018907-c84t1bo5 138 19 broaden broaden VB cord-018907-c84t1bo5 138 20 the the DT cord-018907-c84t1bo5 138 21 coverage coverage NN cord-018907-c84t1bo5 138 22 ( ( -LRB- cord-018907-c84t1bo5 138 23 carbapenems carbapenem NNS cord-018907-c84t1bo5 138 24 if if IN cord-018907-c84t1bo5 138 25 the the DT cord-018907-c84t1bo5 138 26 data datum NNS cord-018907-c84t1bo5 138 27 in in IN cord-018907-c84t1bo5 138 28 the the DT cord-018907-c84t1bo5 138 29 center center NN cord-018907-c84t1bo5 138 30 showed show VBD cord-018907-c84t1bo5 138 31 that that IN cord-018907-c84t1bo5 138 32 the the DT cord-018907-c84t1bo5 138 33 carbapenems carbapenem NNS cord-018907-c84t1bo5 138 34 has have VBZ cord-018907-c84t1bo5 138 35 better well JJR cord-018907-c84t1bo5 138 36 sensitivity sensitivity NN cord-018907-c84t1bo5 138 37 than than IN cord-018907-c84t1bo5 138 38 cephalosporin cephalosporin NN cord-018907-c84t1bo5 138 39 or or CC cord-018907-c84t1bo5 138 40 beta beta NN cord-018907-c84t1bo5 138 41 - - HYPH cord-018907-c84t1bo5 138 42 lactam lactam NNS cord-018907-c84t1bo5 138 43 antibiotic antibiotic NN cord-018907-c84t1bo5 138 44 ) ) -RRB- cord-018907-c84t1bo5 138 45 . . . cord-018907-c84t1bo5 139 1 If if IN cord-018907-c84t1bo5 139 2 the the DT cord-018907-c84t1bo5 139 3 patient patient NN cord-018907-c84t1bo5 139 4 has have VBZ cord-018907-c84t1bo5 139 5 catheter catheter NN cord-018907-c84t1bo5 139 6 - - HYPH cord-018907-c84t1bo5 139 7 associated associate VBN cord-018907-c84t1bo5 139 8 soft soft JJ cord-018907-c84t1bo5 139 9 tissue tissue NN cord-018907-c84t1bo5 139 10 infection infection NN cord-018907-c84t1bo5 139 11 , , , cord-018907-c84t1bo5 139 12 vancomycin vancomycin FW cord-018907-c84t1bo5 139 13 should should MD cord-018907-c84t1bo5 139 14 be be VB cord-018907-c84t1bo5 139 15 added add VBN cord-018907-c84t1bo5 139 16 . . . cord-018907-c84t1bo5 140 1 Patients patient NNS cord-018907-c84t1bo5 140 2 with with IN cord-018907-c84t1bo5 140 3 severe severe JJ cord-018907-c84t1bo5 140 4 oral oral JJ cord-018907-c84t1bo5 140 5 mucositis mucositis NN cord-018907-c84t1bo5 140 6 or or CC cord-018907-c84t1bo5 140 7 necrotizing necrotize VBG cord-018907-c84t1bo5 140 8 gingivitis gingivitis NN cord-018907-c84t1bo5 140 9 are be VBP cord-018907-c84t1bo5 140 10 at at IN cord-018907-c84t1bo5 140 11 risk risk NN cord-018907-c84t1bo5 140 12 of of IN cord-018907-c84t1bo5 140 13 anaerobic anaerobic JJ cord-018907-c84t1bo5 140 14 bacteria bacteria NNS cord-018907-c84t1bo5 140 15 as as RB cord-018907-c84t1bo5 140 16 well well RB cord-018907-c84t1bo5 140 17 as as IN cord-018907-c84t1bo5 140 18 viruses virus NNS cord-018907-c84t1bo5 140 19 ; ; : cord-018907-c84t1bo5 140 20 add add VB cord-018907-c84t1bo5 140 21 agent agent NN cord-018907-c84t1bo5 140 22 that that WDT cord-018907-c84t1bo5 140 23 is be VBZ cord-018907-c84t1bo5 140 24 active active JJ cord-018907-c84t1bo5 140 25 against against IN cord-018907-c84t1bo5 140 26 beta beta NN cord-018907-c84t1bo5 140 27 - - HYPH cord-018907-c84t1bo5 140 28 lactamase lactamase RB cord-018907-c84t1bo5 140 29 - - HYPH cord-018907-c84t1bo5 140 30 producing produce VBG cord-018907-c84t1bo5 140 31 anaerobic anaerobic JJ cord-018907-c84t1bo5 140 32 bacteria bacteria NNS cord-018907-c84t1bo5 140 33 including include VBG cord-018907-c84t1bo5 140 34 clindamycin clindamycin NN cord-018907-c84t1bo5 140 35 , , , cord-018907-c84t1bo5 140 36 metronidazole metronidazole NN cord-018907-c84t1bo5 140 37 , , , cord-018907-c84t1bo5 140 38 and and CC cord-018907-c84t1bo5 140 39 acyclovir acyclovir NNP cord-018907-c84t1bo5 140 40 should should MD cord-018907-c84t1bo5 140 41 be be VB cord-018907-c84t1bo5 140 42 considered consider VBN cord-018907-c84t1bo5 140 43 . . . cord-018907-c84t1bo5 141 1 If if IN cord-018907-c84t1bo5 141 2 the the DT cord-018907-c84t1bo5 141 3 patient patient NN cord-018907-c84t1bo5 141 4 has have VBZ cord-018907-c84t1bo5 141 5 diffuse diffuse JJ cord-018907-c84t1bo5 141 6 pneumonia pneumonia NN cord-018907-c84t1bo5 141 7 , , , cord-018907-c84t1bo5 141 8 continue continue VB cord-018907-c84t1bo5 141 9 with with IN cord-018907-c84t1bo5 141 10 the the DT cord-018907-c84t1bo5 141 11 broad broad JJ cord-018907-c84t1bo5 141 12 - - HYPH cord-018907-c84t1bo5 141 13 spectrum spectrum NN cord-018907-c84t1bo5 141 14 anti anti JJ cord-018907-c84t1bo5 141 15 - - JJ cord-018907-c84t1bo5 141 16 Gramnegative gramnegative JJ cord-018907-c84t1bo5 141 17 coverage coverage NN cord-018907-c84t1bo5 141 18 ( ( -LRB- cord-018907-c84t1bo5 141 19 add add VB cord-018907-c84t1bo5 141 20 trimethoprim trimethoprim NNP cord-018907-c84t1bo5 141 21 - - HYPH cord-018907-c84t1bo5 141 22 sulfamethoxazole sulfamethoxazole NNP cord-018907-c84t1bo5 141 23 and and CC cord-018907-c84t1bo5 141 24 macrolide macrolide NN cord-018907-c84t1bo5 141 25 to to IN cord-018907-c84t1bo5 141 26 the the DT cord-018907-c84t1bo5 141 27 therapy therapy NN cord-018907-c84t1bo5 141 28 ) ) -RRB- cord-018907-c84t1bo5 141 29 . . . cord-018907-c84t1bo5 142 1 Increasing increase VBG cord-018907-c84t1bo5 142 2 neutrophil neutrophil NN cord-018907-c84t1bo5 142 3 count count NN cord-018907-c84t1bo5 142 4 on on IN cord-018907-c84t1bo5 142 5 patients patient NNS cord-018907-c84t1bo5 142 6 who who WP cord-018907-c84t1bo5 142 7 developed develop VBD cord-018907-c84t1bo5 142 8 new new JJ cord-018907-c84t1bo5 142 9 infiltrates infiltrate NNS cord-018907-c84t1bo5 142 10 while while IN cord-018907-c84t1bo5 142 11 on on IN cord-018907-c84t1bo5 142 12 antibiotic antibiotic NN cord-018907-c84t1bo5 142 13 can can MD cord-018907-c84t1bo5 142 14 be be VB cord-018907-c84t1bo5 142 15 related relate VBN cord-018907-c84t1bo5 142 16 to to IN cord-018907-c84t1bo5 142 17 the the DT cord-018907-c84t1bo5 142 18 recovery recovery NN cord-018907-c84t1bo5 142 19 of of IN cord-018907-c84t1bo5 142 20 neutropenia neutropenia NN cord-018907-c84t1bo5 142 21 . . . cord-018907-c84t1bo5 143 1 If if IN cord-018907-c84t1bo5 143 2 the the DT cord-018907-c84t1bo5 143 3 patient patient NN cord-018907-c84t1bo5 143 4 is be VBZ cord-018907-c84t1bo5 143 5 stable stable JJ cord-018907-c84t1bo5 143 6 observe observe NN cord-018907-c84t1bo5 143 7 if if IN cord-018907-c84t1bo5 143 8 the the DT cord-018907-c84t1bo5 143 9 neutrophil neutrophil NN cord-018907-c84t1bo5 143 10 count count NN cord-018907-c84t1bo5 143 11 is be VBZ cord-018907-c84t1bo5 143 12 not not RB cord-018907-c84t1bo5 143 13 rising rise VBG cord-018907-c84t1bo5 143 14 , , , cord-018907-c84t1bo5 143 15 antifungal antifungal JJ cord-018907-c84t1bo5 143 16 therapy therapy NN cord-018907-c84t1bo5 143 17 should should MD cord-018907-c84t1bo5 143 18 be be VB cord-018907-c84t1bo5 143 19 considered consider VBN cord-018907-c84t1bo5 143 20 as as IN cord-018907-c84t1bo5 143 21 the the DT cord-018907-c84t1bo5 143 22 patient patient NN cord-018907-c84t1bo5 143 23 is be VBZ cord-018907-c84t1bo5 143 24 at at IN cord-018907-c84t1bo5 143 25 risk risk NN cord-018907-c84t1bo5 143 26 for for IN cord-018907-c84t1bo5 143 27 fungal fungal JJ cord-018907-c84t1bo5 143 28 infection infection NN cord-018907-c84t1bo5 143 29 . . . cord-018907-c84t1bo5 144 1 In in IN cord-018907-c84t1bo5 144 2 addition addition NN cord-018907-c84t1bo5 144 3 to to IN cord-018907-c84t1bo5 144 4 other other JJ cord-018907-c84t1bo5 144 5 evaluation evaluation NN cord-018907-c84t1bo5 144 6 Aspergillus aspergillus NN cord-018907-c84t1bo5 144 7 galactomannan galactomannan NN cord-018907-c84t1bo5 144 8 and and CC cord-018907-c84t1bo5 144 9 B B NNP cord-018907-c84t1bo5 144 10 - - HYPH cord-018907-c84t1bo5 144 11 D D NNP cord-018907-c84t1bo5 144 12 glucan glucan NN cord-018907-c84t1bo5 144 13 ( ( -LRB- cord-018907-c84t1bo5 144 14 fungitell fungitell NNP cord-018907-c84t1bo5 144 15 ) ) -RRB- cord-018907-c84t1bo5 144 16 should should MD cord-018907-c84t1bo5 144 17 be be VB cord-018907-c84t1bo5 144 18 done do VBN cord-018907-c84t1bo5 144 19 with with IN cord-018907-c84t1bo5 144 20 chest chest NN cord-018907-c84t1bo5 144 21 CT CT NNP cord-018907-c84t1bo5 144 22 scan scan NN cord-018907-c84t1bo5 144 23 . . . cord-018907-c84t1bo5 145 1 Depending depend VBG cord-018907-c84t1bo5 145 2 on on IN cord-018907-c84t1bo5 145 3 the the DT cord-018907-c84t1bo5 145 4 CT CT NNP cord-018907-c84t1bo5 145 5 scan scan JJ cord-018907-c84t1bo5 145 6 findings finding NNS cord-018907-c84t1bo5 145 7 bronchoalveolar bronchoalveolar NNP cord-018907-c84t1bo5 145 8 lavage lavage NN cord-018907-c84t1bo5 145 9 or or CC cord-018907-c84t1bo5 145 10 lung lung NN cord-018907-c84t1bo5 145 11 biopsy biopsy NN cord-018907-c84t1bo5 145 12 should should MD cord-018907-c84t1bo5 145 13 be be VB cord-018907-c84t1bo5 145 14 considered consider VBN cord-018907-c84t1bo5 145 15 . . . cord-018907-c84t1bo5 146 1 Patient patient JJ cord-018907-c84t1bo5 146 2 with with IN cord-018907-c84t1bo5 146 3 prolonged prolonged JJ cord-018907-c84t1bo5 146 4 fever fever NN cord-018907-c84t1bo5 146 5 and and CC cord-018907-c84t1bo5 146 6 neutropenia neutropenia NN cord-018907-c84t1bo5 146 7 needs need VBZ cord-018907-c84t1bo5 146 8 to to TO cord-018907-c84t1bo5 146 9 be be VB cord-018907-c84t1bo5 146 10 observed observe VBN cord-018907-c84t1bo5 146 11 if if IN cord-018907-c84t1bo5 146 12 recovery recovery NN cord-018907-c84t1bo5 146 13 of of IN cord-018907-c84t1bo5 146 14 neutropenia neutropenia NN cord-018907-c84t1bo5 146 15 is be VBZ cord-018907-c84t1bo5 146 16 not not RB cord-018907-c84t1bo5 146 17 imminent imminent JJ cord-018907-c84t1bo5 146 18 . . . cord-018907-c84t1bo5 147 1 Antifungal antifungal JJ cord-018907-c84t1bo5 147 2 therapy therapy NN cord-018907-c84t1bo5 147 3 can can MD cord-018907-c84t1bo5 147 4 include include VB cord-018907-c84t1bo5 147 5 either either CC cord-018907-c84t1bo5 147 6 regular regular JJ cord-018907-c84t1bo5 147 7 amphotericin amphotericin NNS cord-018907-c84t1bo5 147 8 B b NN cord-018907-c84t1bo5 147 9 , , , cord-018907-c84t1bo5 147 10 or or CC cord-018907-c84t1bo5 147 11 lipid lipid NN cord-018907-c84t1bo5 147 12 formulation formulation NN cord-018907-c84t1bo5 147 13 of of IN cord-018907-c84t1bo5 147 14 amphotericin amphotericin NNS cord-018907-c84t1bo5 147 15 B B NNP cord-018907-c84t1bo5 147 16 including include VBG cord-018907-c84t1bo5 147 17 liposomal liposomal IN cord-018907-c84t1bo5 147 18 amphotericin amphotericin NNS cord-018907-c84t1bo5 147 19 B b NN cord-018907-c84t1bo5 147 20 ( ( -LRB- cord-018907-c84t1bo5 147 21 amBisome ambisome NN cord-018907-c84t1bo5 147 22 ) ) -RRB- cord-018907-c84t1bo5 147 23 or or CC cord-018907-c84t1bo5 147 24 amphotericin amphotericin NNS cord-018907-c84t1bo5 147 25 B b NN cord-018907-c84t1bo5 147 26 lipid lipid NN cord-018907-c84t1bo5 147 27 complex complex NN cord-018907-c84t1bo5 147 28 ( ( -LRB- cord-018907-c84t1bo5 147 29 ABLC ABLC NNP cord-018907-c84t1bo5 147 30 ) ) -RRB- cord-018907-c84t1bo5 147 31 , , , cord-018907-c84t1bo5 147 32 caspofungin caspofungin NNP cord-018907-c84t1bo5 147 33 or or CC cord-018907-c84t1bo5 147 34 voriconazole voriconazole NN cord-018907-c84t1bo5 147 35 depending depend VBG cord-018907-c84t1bo5 147 36 of of IN cord-018907-c84t1bo5 147 37 the the DT cord-018907-c84t1bo5 147 38 availability availability NN cord-018907-c84t1bo5 147 39 of of IN cord-018907-c84t1bo5 147 40 medications medication NNS cord-018907-c84t1bo5 147 41 and and CC cord-018907-c84t1bo5 147 42 epidemiology epidemiology NN cord-018907-c84t1bo5 147 43 of of IN cord-018907-c84t1bo5 147 44 the the DT cord-018907-c84t1bo5 147 45 institution institution NN cord-018907-c84t1bo5 147 46 . . . cord-018907-c84t1bo5 148 1 Infections infection NNS cord-018907-c84t1bo5 148 2 in in IN cord-018907-c84t1bo5 148 3 the the DT cord-018907-c84t1bo5 148 4 immunocompromised immunocompromised JJ cord-018907-c84t1bo5 148 5 Low low JJ cord-018907-c84t1bo5 148 6 risk risk NN cord-018907-c84t1bo5 148 7 episodes episode NNS cord-018907-c84t1bo5 148 8 of of IN cord-018907-c84t1bo5 148 9 fever fever NN cord-018907-c84t1bo5 148 10 and and CC cord-018907-c84t1bo5 148 11 neutropenia neutropenia NN cord-018907-c84t1bo5 148 12 in in IN cord-018907-c84t1bo5 148 13 pediatric pediatric JJ cord-018907-c84t1bo5 148 14 oncology oncology NN cord-018907-c84t1bo5 148 15 : : : cord-018907-c84t1bo5 148 16 is be VBZ cord-018907-c84t1bo5 148 17 outpatient outpatient JJ cord-018907-c84t1bo5 148 18 oral oral JJ cord-018907-c84t1bo5 148 19 antibiotic antibiotic JJ cord-018907-c84t1bo5 148 20 therapy therapy NN cord-018907-c84t1bo5 148 21 the the DT cord-018907-c84t1bo5 148 22 new new JJ cord-018907-c84t1bo5 148 23 gold gold NN cord-018907-c84t1bo5 148 24 standard standard JJ cord-018907-c84t1bo5 148 25 care care NN cord-018907-c84t1bo5 148 26 ? ? . cord-018907-c84t1bo5 149 1 Predicting predict VBG cord-018907-c84t1bo5 149 2 events event NNS cord-018907-c84t1bo5 149 3 in in IN cord-018907-c84t1bo5 149 4 children child NNS cord-018907-c84t1bo5 149 5 with with IN cord-018907-c84t1bo5 149 6 fever fever NN cord-018907-c84t1bo5 149 7 and and CC cord-018907-c84t1bo5 150 1 chemotherapy chemotherapy NN cord-018907-c84t1bo5 150 2 - - HYPH cord-018907-c84t1bo5 150 3 induced induce VBN cord-018907-c84t1bo5 150 4 neutropenia neutropenia NN cord-018907-c84t1bo5 150 5 : : : cord-018907-c84t1bo5 150 6 the the DT cord-018907-c84t1bo5 150 7 prospective prospective JJ cord-018907-c84t1bo5 150 8 multicenter multicenter JJ cord-018907-c84t1bo5 150 9 SPOG SPOG NNP cord-018907-c84t1bo5 150 10 2003 2003 CD cord-018907-c84t1bo5 150 11 FN FN NNP cord-018907-c84t1bo5 150 12 study study NN cord-018907-c84t1bo5 150 13 Cefepime Cefepime NNP cord-018907-c84t1bo5 150 14 and and CC cord-018907-c84t1bo5 150 15 death death NN cord-018907-c84t1bo5 150 16 : : : cord-018907-c84t1bo5 150 17 reality reality NN cord-018907-c84t1bo5 150 18 to to TO cord-018907-c84t1bo5 150 19 rescue rescue VB cord-018907-c84t1bo5 150 20 Clinical clinical JJ cord-018907-c84t1bo5 150 21 practice practice NN cord-018907-c84t1bo5 150 22 guideline guideline NN cord-018907-c84t1bo5 150 23 for for IN cord-018907-c84t1bo5 150 24 the the DT cord-018907-c84t1bo5 150 25 use use NN cord-018907-c84t1bo5 150 26 of of IN cord-018907-c84t1bo5 150 27 antimicrobial antimicrobial JJ cord-018907-c84t1bo5 150 28 agents agent NNS cord-018907-c84t1bo5 150 29 in in IN cord-018907-c84t1bo5 150 30 neutropenic neutropenic JJ cord-018907-c84t1bo5 150 31 patients patient NNS cord-018907-c84t1bo5 150 32 with with IN cord-018907-c84t1bo5 150 33 cancer cancer NN cord-018907-c84t1bo5 150 34 : : : cord-018907-c84t1bo5 151 1 2010 2010 CD cord-018907-c84t1bo5 151 2 update update NN cord-018907-c84t1bo5 151 3 by by IN cord-018907-c84t1bo5 151 4 the the DT cord-018907-c84t1bo5 151 5 infectious infectious JJ cord-018907-c84t1bo5 151 6 society society NN cord-018907-c84t1bo5 151 7 of of IN cord-018907-c84t1bo5 151 8 America America NNP cord-018907-c84t1bo5 151 9 Etiology Etiology NNP cord-018907-c84t1bo5 151 10 and and CC cord-018907-c84t1bo5 151 11 clinical clinical JJ cord-018907-c84t1bo5 151 12 course course NN cord-018907-c84t1bo5 151 13 of of IN cord-018907-c84t1bo5 151 14 febrile febrile JJ cord-018907-c84t1bo5 151 15 neutropenia neutropenia NN cord-018907-c84t1bo5 151 16 in in IN cord-018907-c84t1bo5 151 17 children child NNS cord-018907-c84t1bo5 151 18 with with IN cord-018907-c84t1bo5 151 19 cancer cancer NN cord-018907-c84t1bo5 151 20 Risk Risk NNP cord-018907-c84t1bo5 151 21 prediction prediction NN cord-018907-c84t1bo5 151 22 in in IN cord-018907-c84t1bo5 151 23 pediatric pediatric JJ cord-018907-c84t1bo5 151 24 cancer cancer NN cord-018907-c84t1bo5 151 25 patients patient NNS cord-018907-c84t1bo5 151 26 with with IN cord-018907-c84t1bo5 151 27 fever fever NN cord-018907-c84t1bo5 151 28 and and CC cord-018907-c84t1bo5 151 29 neutopenia neutopenia NNP cord-018907-c84t1bo5 151 30 Advances advance VBZ cord-018907-c84t1bo5 151 31 in in IN cord-018907-c84t1bo5 151 32 the the DT cord-018907-c84t1bo5 151 33 management management NN cord-018907-c84t1bo5 151 34 of of IN cord-018907-c84t1bo5 151 35 primary primary JJ cord-018907-c84t1bo5 151 36 immunodeficiency immunodeficiency NN cord-018907-c84t1bo5 151 37 Immunocompromised immunocompromise VBN cord-018907-c84t1bo5 151 38 children child NNS cord-018907-c84t1bo5 151 39 : : : cord-018907-c84t1bo5 151 40 conditions condition NNS cord-018907-c84t1bo5 151 41 and and CC cord-018907-c84t1bo5 151 42 infectious infectious JJ cord-018907-c84t1bo5 151 43 agents agent NNS cord-018907-c84t1bo5 151 44 Emprical Emprical NNP cord-018907-c84t1bo5 151 45 oral oral JJ cord-018907-c84t1bo5 151 46 antibiotic antibiotic JJ cord-018907-c84t1bo5 151 47 therapy therapy NN cord-018907-c84t1bo5 151 48 for for IN cord-018907-c84t1bo5 151 49 low low JJ cord-018907-c84t1bo5 151 50 risk risk NN cord-018907-c84t1bo5 151 51 febrile febrile JJ cord-018907-c84t1bo5 151 52 cancer cancer NN cord-018907-c84t1bo5 151 53 patients patient NNS cord-018907-c84t1bo5 151 54 with with IN cord-018907-c84t1bo5 151 55 neutropenia neutropenia NNP cord-018907-c84t1bo5 151 56 Meta Meta NNP cord-018907-c84t1bo5 151 57 - - HYPH cord-018907-c84t1bo5 151 58 Analysis Analysis NNP cord-018907-c84t1bo5 151 59 of of IN cord-018907-c84t1bo5 151 60 a a DT cord-018907-c84t1bo5 151 61 possible possible JJ cord-018907-c84t1bo5 151 62 signal signal NN cord-018907-c84t1bo5 151 63 of of IN cord-018907-c84t1bo5 151 64 increased increase VBN cord-018907-c84t1bo5 151 65 mortality mortality NN cord-018907-c84t1bo5 151 66 associated associate VBN cord-018907-c84t1bo5 151 67 with with IN cord-018907-c84t1bo5 151 68 cefepime cefepime NNP cord-018907-c84t1bo5 151 69 use use VBP cord-018907-c84t1bo5 151 70 Febrile febrile JJ cord-018907-c84t1bo5 151 71 neutropenia neutropenia NN cord-018907-c84t1bo5 151 72 : : : cord-018907-c84t1bo5 151 73 a a DT cord-018907-c84t1bo5 151 74 critical critical JJ cord-018907-c84t1bo5 151 75 review review NN cord-018907-c84t1bo5 151 76 of of IN cord-018907-c84t1bo5 151 77 the the DT cord-018907-c84t1bo5 151 78 initial initial JJ cord-018907-c84t1bo5 151 79 MANAGEMENT management NN cord-018907-c84t1bo5 151 80 Fever Fever NNP cord-018907-c84t1bo5 151 81 and and CC cord-018907-c84t1bo5 151 82 neutropenia neutropenia NN cord-018907-c84t1bo5 151 83 in in IN cord-018907-c84t1bo5 151 84 pediatric pediatric JJ cord-018907-c84t1bo5 151 85 patients patient NNS cord-018907-c84t1bo5 151 86 with with IN cord-018907-c84t1bo5 151 87 cancer cancer NN cord-018907-c84t1bo5 151 88 ) ) -RRB- cord-018907-c84t1bo5 152 1 b b LS cord-018907-c84t1bo5 152 2 lactam lactam NNP cord-018907-c84t1bo5 152 3 monotherapy monotherapy NN cord-018907-c84t1bo5 152 4 versus versus IN cord-018907-c84t1bo5 152 5 b b LS cord-018907-c84t1bo5 152 6 lactam lactam NN cord-018907-c84t1bo5 152 7 - - HYPH cord-018907-c84t1bo5 152 8 aminoglycoside aminoglycoside NN cord-018907-c84t1bo5 152 9 combination combination NN cord-018907-c84t1bo5 152 10 therapy therapy NN cord-018907-c84t1bo5 152 11 for for IN cord-018907-c84t1bo5 152 12 sepsis sepsis NN cord-018907-c84t1bo5 152 13 in in IN cord-018907-c84t1bo5 152 14 immunocompetent immunocompetent JJ cord-018907-c84t1bo5 152 15 patients patient NNS cord-018907-c84t1bo5 152 16 : : : cord-018907-c84t1bo5 152 17 systemic systemic JJ cord-018907-c84t1bo5 152 18 review review NN cord-018907-c84t1bo5 152 19 and and CC cord-018907-c84t1bo5 152 20 meta meta NNP cord-018907-c84t1bo5 152 21 - - HYPH cord-018907-c84t1bo5 152 22 analysis analysis NN cord-018907-c84t1bo5 152 23 of of IN cord-018907-c84t1bo5 152 24 randomized randomized JJ cord-018907-c84t1bo5 152 25 trials trial NNS cord-018907-c84t1bo5 152 26 Fever Fever NNP cord-018907-c84t1bo5 152 27 in in IN cord-018907-c84t1bo5 152 28 immunocompromised immunocompromised JJ cord-018907-c84t1bo5 152 29 patients patient NNS cord-018907-c84t1bo5 152 30 Bloodstream bloodstream JJ cord-018907-c84t1bo5 152 31 infections infection NNS cord-018907-c84t1bo5 152 32 in in IN cord-018907-c84t1bo5 152 33 hematology hematology NN cord-018907-c84t1bo5 152 34 : : : cord-018907-c84t1bo5 152 35 risks risk NNS cord-018907-c84t1bo5 152 36 and and CC cord-018907-c84t1bo5 152 37 new new JJ cord-018907-c84t1bo5 152 38 challenges challenge NNS cord-018907-c84t1bo5 152 39 for for IN cord-018907-c84t1bo5 152 40 prevention prevention NN cord-018907-c84t1bo5 152 41 Pediatric pediatric JJ cord-018907-c84t1bo5 152 42 cancer cancer NN cord-018907-c84t1bo5 152 43 patients patient NNS cord-018907-c84t1bo5 152 44 in in IN cord-018907-c84t1bo5 152 45 clinical clinical JJ cord-018907-c84t1bo5 152 46 trials trial NNS cord-018907-c84t1bo5 152 47 of of IN cord-018907-c84t1bo5 152 48 sepsis sepsis NN cord-018907-c84t1bo5 152 49 : : : cord-018907-c84t1bo5 152 50 factors factor NNS cord-018907-c84t1bo5 152 51 that that WDT cord-018907-c84t1bo5 152 52 predispose predispose VBP cord-018907-c84t1bo5 152 53 to to TO cord-018907-c84t1bo5 152 54 sepsis sepsis VB cord-018907-c84t1bo5 152 55 and and CC cord-018907-c84t1bo5 152 56 stratify stratify VB cord-018907-c84t1bo5 152 57 outcome outcome NN