id sid tid token lemma pos cord-018017-c8myq6bi 1 1 key key NN cord-018017-c8myq6bi 1 2 : : : cord-018017-c8myq6bi 1 3 cord-018017-c8myq6bi cord-018017-c8myq6bi IN cord-018017-c8myq6bi 1 4 authors author NNS cord-018017-c8myq6bi 1 5 : : : cord-018017-c8myq6bi 1 6 Iversen Iversen NNP cord-018017-c8myq6bi 1 7 , , , cord-018017-c8myq6bi 1 8 Patrick Patrick NNP cord-018017-c8myq6bi 1 9 L. L. NNP cord-018017-c8myq6bi 1 10 title title NN cord-018017-c8myq6bi 1 11 : : : cord-018017-c8myq6bi 1 12 The the DT cord-018017-c8myq6bi 1 13 Threat threat NN cord-018017-c8myq6bi 1 14 from from IN cord-018017-c8myq6bi 1 15 Viruses virus NNS cord-018017-c8myq6bi 1 16 date date NN cord-018017-c8myq6bi 1 17 : : : cord-018017-c8myq6bi 1 18 2018 2018 CD cord-018017-c8myq6bi 1 19 - - HYPH cord-018017-c8myq6bi 1 20 09 09 CD cord-018017-c8myq6bi 1 21 - - SYM cord-018017-c8myq6bi 1 22 30 30 CD cord-018017-c8myq6bi 1 23 journal journal NN cord-018017-c8myq6bi 1 24 : : : cord-018017-c8myq6bi 2 1 Molecular molecular JJ cord-018017-c8myq6bi 2 2 Basis Basis NNP cord-018017-c8myq6bi 2 3 of of IN cord-018017-c8myq6bi 2 4 Resilience Resilience NNP cord-018017-c8myq6bi 2 5 DOI DOI NNP cord-018017-c8myq6bi 2 6 : : : cord-018017-c8myq6bi 3 1 10.1007/978 10.1007/978 LS cord-018017-c8myq6bi 3 2 - - SYM cord-018017-c8myq6bi 3 3 3 3 CD cord-018017-c8myq6bi 3 4 - - HYPH cord-018017-c8myq6bi 3 5 319 319 CD cord-018017-c8myq6bi 3 6 - - HYPH cord-018017-c8myq6bi 3 7 98164 98164 CD cord-018017-c8myq6bi 3 8 - - SYM cord-018017-c8myq6bi 3 9 2_3 2_3 CD cord-018017-c8myq6bi 3 10 sha sha NNP cord-018017-c8myq6bi 3 11 : : : cord-018017-c8myq6bi 4 1 637895311fa48cbc81bb6b23135a382202cb1f8d 637895311fa48cbc81bb6b23135a382202cb1f8d CD cord-018017-c8myq6bi 5 1 doc_id doc_id CD cord-018017-c8myq6bi 5 2 : : : cord-018017-c8myq6bi 6 1 18017 18017 CD cord-018017-c8myq6bi 6 2 cord_uid cord_uid NN cord-018017-c8myq6bi 6 3 : : : cord-018017-c8myq6bi 7 1 c8myq6bi c8myq6bi NNP cord-018017-c8myq6bi 7 2 Infectious infectious JJ cord-018017-c8myq6bi 7 3 disease disease NN cord-018017-c8myq6bi 7 4 represent represent VBP cord-018017-c8myq6bi 7 5 the the DT cord-018017-c8myq6bi 7 6 most most RBS cord-018017-c8myq6bi 7 7 significant significant JJ cord-018017-c8myq6bi 7 8 threat threat NN cord-018017-c8myq6bi 7 9 to to IN cord-018017-c8myq6bi 7 10 human human JJ cord-018017-c8myq6bi 7 11 health health NN cord-018017-c8myq6bi 7 12 . . . cord-018017-c8myq6bi 8 1 Significant significant JJ cord-018017-c8myq6bi 8 2 geologic geologic JJ cord-018017-c8myq6bi 8 3 cataclysmic cataclysmic JJ cord-018017-c8myq6bi 8 4 events event NNS cord-018017-c8myq6bi 8 5 have have VBP cord-018017-c8myq6bi 8 6 caused cause VBN cord-018017-c8myq6bi 8 7 the the DT cord-018017-c8myq6bi 8 8 extinction extinction NN cord-018017-c8myq6bi 8 9 of of IN cord-018017-c8myq6bi 8 10 countless countless JJ cord-018017-c8myq6bi 8 11 species specie NNS cord-018017-c8myq6bi 8 12 , , , cord-018017-c8myq6bi 8 13 but but CC cord-018017-c8myq6bi 8 14 these these DT cord-018017-c8myq6bi 8 15 “ " `` cord-018017-c8myq6bi 8 16 Wrath wrath NN cord-018017-c8myq6bi 8 17 of of IN cord-018017-c8myq6bi 8 18 God God NNP cord-018017-c8myq6bi 8 19 ” " '' cord-018017-c8myq6bi 8 20 events event NNS cord-018017-c8myq6bi 8 21 predate predate VBP cord-018017-c8myq6bi 8 22 the the DT cord-018017-c8myq6bi 8 23 emergence emergence NN cord-018017-c8myq6bi 8 24 of of IN cord-018017-c8myq6bi 8 25 Homo homo NN cord-018017-c8myq6bi 8 26 sapiens sapiens JJ cord-018017-c8myq6bi 8 27 . . . cord-018017-c8myq6bi 9 1 Pandemic pandemic NN cord-018017-c8myq6bi 9 2 infections infection NNS cord-018017-c8myq6bi 9 3 have have VBP cord-018017-c8myq6bi 9 4 accompanied accompany VBN cord-018017-c8myq6bi 9 5 the the DT cord-018017-c8myq6bi 9 6 rise rise NN cord-018017-c8myq6bi 9 7 of of IN cord-018017-c8myq6bi 9 8 human human JJ cord-018017-c8myq6bi 9 9 civilization civilization NN cord-018017-c8myq6bi 9 10 frequently frequently RB cord-018017-c8myq6bi 9 11 re re VBD cord-018017-c8myq6bi 9 12 - - VBG cord-018017-c8myq6bi 9 13 occurring occur VBG cord-018017-c8myq6bi 9 14 leaving leave VBG cord-018017-c8myq6bi 9 15 a a DT cord-018017-c8myq6bi 9 16 lasting last VBG cord-018017-c8myq6bi 9 17 imprint imprint NN cord-018017-c8myq6bi 9 18 on on IN cord-018017-c8myq6bi 9 19 human human JJ cord-018017-c8myq6bi 9 20 history history NN cord-018017-c8myq6bi 9 21 punctuated punctuate VBN cord-018017-c8myq6bi 9 22 by by IN cord-018017-c8myq6bi 9 23 profound profound JJ cord-018017-c8myq6bi 9 24 loss loss NN cord-018017-c8myq6bi 9 25 of of IN cord-018017-c8myq6bi 9 26 life life NN cord-018017-c8myq6bi 9 27 . . . cord-018017-c8myq6bi 10 1 Emerging emerge VBG cord-018017-c8myq6bi 10 2 infections infection NNS cord-018017-c8myq6bi 10 3 become become VBP cord-018017-c8myq6bi 10 4 endemic endemic JJ cord-018017-c8myq6bi 10 5 and and CC cord-018017-c8myq6bi 10 6 are be VBP cord-018017-c8myq6bi 10 7 here here RB cord-018017-c8myq6bi 10 8 to to TO cord-018017-c8myq6bi 10 9 stay stay VB cord-018017-c8myq6bi 10 10 marking mark VBG cord-018017-c8myq6bi 10 11 their -PRON- PRP$ cord-018017-c8myq6bi 10 12 presence presence NN cord-018017-c8myq6bi 10 13 with with IN cord-018017-c8myq6bi 10 14 an an DT cord-018017-c8myq6bi 10 15 annual annual JJ cord-018017-c8myq6bi 10 16 death death NN cord-018017-c8myq6bi 10 17 toll toll NN cord-018017-c8myq6bi 10 18 . . . cord-018017-c8myq6bi 11 1 Each each DT cord-018017-c8myq6bi 11 2 decade decade NN cord-018017-c8myq6bi 11 3 brings bring VBZ cord-018017-c8myq6bi 11 4 a a DT cord-018017-c8myq6bi 11 5 new new JJ cord-018017-c8myq6bi 11 6 onslaught onslaught NN cord-018017-c8myq6bi 11 7 of of IN cord-018017-c8myq6bi 11 8 emerging emerge VBG cord-018017-c8myq6bi 11 9 infectious infectious JJ cord-018017-c8myq6bi 11 10 agents agent NNS cord-018017-c8myq6bi 11 11 . . . cord-018017-c8myq6bi 12 1 We -PRON- PRP cord-018017-c8myq6bi 12 2 are be VBP cord-018017-c8myq6bi 12 3 surprised surprised JJ cord-018017-c8myq6bi 12 4 again again RB cord-018017-c8myq6bi 12 5 and and CC cord-018017-c8myq6bi 12 6 again again RB cord-018017-c8myq6bi 12 7 but but CC cord-018017-c8myq6bi 12 8 are be VBP cord-018017-c8myq6bi 12 9 never never RB cord-018017-c8myq6bi 12 10 prepared prepare VBN cord-018017-c8myq6bi 12 11 . . . cord-018017-c8myq6bi 13 1 The the DT cord-018017-c8myq6bi 13 2 long long JJ cord-018017-c8myq6bi 13 3 - - HYPH cord-018017-c8myq6bi 13 4 term term NN cord-018017-c8myq6bi 13 5 consequences consequence NNS cord-018017-c8myq6bi 13 6 often often RB cord-018017-c8myq6bi 13 7 remain remain VBP cord-018017-c8myq6bi 13 8 unrecognized unrecognized JJ cord-018017-c8myq6bi 13 9 and and CC cord-018017-c8myq6bi 13 10 are be VBP cord-018017-c8myq6bi 13 11 always always RB cord-018017-c8myq6bi 13 12 inconvenient inconvenient JJ cord-018017-c8myq6bi 13 13 including include VBG cord-018017-c8myq6bi 13 14 cancer cancer NN cord-018017-c8myq6bi 13 15 , , , cord-018017-c8myq6bi 13 16 cardiovascular cardiovascular JJ cord-018017-c8myq6bi 13 17 disease disease NN cord-018017-c8myq6bi 13 18 and and CC cord-018017-c8myq6bi 13 19 immune immune JJ cord-018017-c8myq6bi 13 20 associated associate VBN cord-018017-c8myq6bi 13 21 diseases disease NNS cord-018017-c8myq6bi 13 22 that that WDT cord-018017-c8myq6bi 13 23 threaten threaten VBP cord-018017-c8myq6bi 13 24 our -PRON- PRP$ cord-018017-c8myq6bi 13 25 health health NN cord-018017-c8myq6bi 13 26 . . . cord-018017-c8myq6bi 14 1 Reliance reliance NN cord-018017-c8myq6bi 14 2 on on IN cord-018017-c8myq6bi 14 3 clusters cluster NNS cord-018017-c8myq6bi 14 4 of of IN cord-018017-c8myq6bi 14 5 clinical clinical JJ cord-018017-c8myq6bi 14 6 symptoms symptom NNS cord-018017-c8myq6bi 14 7 in in IN cord-018017-c8myq6bi 14 8 the the DT cord-018017-c8myq6bi 14 9 face face NN cord-018017-c8myq6bi 14 10 of of IN cord-018017-c8myq6bi 14 11 diverse diverse JJ cord-018017-c8myq6bi 14 12 and and CC cord-018017-c8myq6bi 14 13 non non JJ cord-018017-c8myq6bi 14 14 - - JJ cord-018017-c8myq6bi 14 15 descriptive descriptive JJ cord-018017-c8myq6bi 14 16 viral viral JJ cord-018017-c8myq6bi 14 17 infection infection NN cord-018017-c8myq6bi 14 18 symptoms symptom NNS cord-018017-c8myq6bi 14 19 is be VBZ cord-018017-c8myq6bi 14 20 a a DT cord-018017-c8myq6bi 14 21 foolhardy foolhardy JJ cord-018017-c8myq6bi 14 22 form form NN cord-018017-c8myq6bi 14 23 of of IN cord-018017-c8myq6bi 14 24 crisis crisis NN cord-018017-c8myq6bi 14 25 management management NN cord-018017-c8myq6bi 14 26 . . . cord-018017-c8myq6bi 15 1 Viral viral JJ cord-018017-c8myq6bi 15 2 success success NN cord-018017-c8myq6bi 15 3 is be VBZ cord-018017-c8myq6bi 15 4 based base VBN cord-018017-c8myq6bi 15 5 on on IN cord-018017-c8myq6bi 15 6 rapid rapid JJ cord-018017-c8myq6bi 15 7 replication replication NN cord-018017-c8myq6bi 15 8 resulting result VBG cord-018017-c8myq6bi 15 9 in in IN cord-018017-c8myq6bi 15 10 large large JJ cord-018017-c8myq6bi 15 11 numbers number NNS cord-018017-c8myq6bi 15 12 . . . cord-018017-c8myq6bi 16 1 Single single JJ cord-018017-c8myq6bi 16 2 - - HYPH cord-018017-c8myq6bi 16 3 stranded strand VBN cord-018017-c8myq6bi 16 4 RNA RNA NNP cord-018017-c8myq6bi 16 5 viruses virus NNS cord-018017-c8myq6bi 16 6 with with IN cord-018017-c8myq6bi 16 7 their -PRON- PRP$ cord-018017-c8myq6bi 16 8 high high JJ cord-018017-c8myq6bi 16 9 replication replication NN cord-018017-c8myq6bi 16 10 error error NN cord-018017-c8myq6bi 16 11 rate rate NN cord-018017-c8myq6bi 16 12 represent represent VBP cord-018017-c8myq6bi 16 13 a a DT cord-018017-c8myq6bi 16 14 paradigm paradigm NN cord-018017-c8myq6bi 16 15 for for IN cord-018017-c8myq6bi 16 16 resilience resilience NN cord-018017-c8myq6bi 16 17 . . . cord-018017-c8myq6bi 17 1 Contemplating contemplate VBG cord-018017-c8myq6bi 17 2 recent recent JJ cord-018017-c8myq6bi 17 3 career career NN cord-018017-c8myq6bi 17 4 paths path NNS cord-018017-c8myq6bi 17 5 , , , cord-018017-c8myq6bi 17 6 I -PRON- PRP cord-018017-c8myq6bi 17 7 reviewed review VBD cord-018017-c8myq6bi 17 8 a a DT cord-018017-c8myq6bi 17 9 broad broad JJ cord-018017-c8myq6bi 17 10 range range NN cord-018017-c8myq6bi 17 11 of of IN cord-018017-c8myq6bi 17 12 scientific scientific JJ cord-018017-c8myq6bi 17 13 questions question NNS cord-018017-c8myq6bi 17 14 . . . cord-018017-c8myq6bi 18 1 Most most RBS cord-018017-c8myq6bi 18 2 prominent prominent JJ cord-018017-c8myq6bi 18 3 was be VBD cord-018017-c8myq6bi 18 4 , , , cord-018017-c8myq6bi 18 5 why why WRB cord-018017-c8myq6bi 18 6 study study VB cord-018017-c8myq6bi 18 7 an an DT cord-018017-c8myq6bi 18 8 area area NN cord-018017-c8myq6bi 18 9 of of IN cord-018017-c8myq6bi 18 10 science science NN cord-018017-c8myq6bi 18 11 that that WDT cord-018017-c8myq6bi 18 12 has have VBZ cord-018017-c8myq6bi 18 13 no no DT cord-018017-c8myq6bi 18 14 significant significant JJ cord-018017-c8myq6bi 18 15 impact impact NN cord-018017-c8myq6bi 18 16 ? ? . cord-018017-c8myq6bi 19 1 In in IN cord-018017-c8myq6bi 19 2 fact fact NN cord-018017-c8myq6bi 19 3 , , , cord-018017-c8myq6bi 19 4 why why WRB cord-018017-c8myq6bi 19 5 study study VB cord-018017-c8myq6bi 19 6 anything anything NN cord-018017-c8myq6bi 19 7 that that WDT cord-018017-c8myq6bi 19 8 is be VBZ cord-018017-c8myq6bi 19 9 not not RB cord-018017-c8myq6bi 19 10 the the DT cord-018017-c8myq6bi 19 11 most most RBS cord-018017-c8myq6bi 19 12 highly highly RB cord-018017-c8myq6bi 19 13 impactful impactful JJ cord-018017-c8myq6bi 19 14 area area NN cord-018017-c8myq6bi 19 15 ? ? . cord-018017-c8myq6bi 20 1 This this DT cord-018017-c8myq6bi 20 2 question question NN cord-018017-c8myq6bi 20 3 demands demand VBZ cord-018017-c8myq6bi 20 4 a a DT cord-018017-c8myq6bi 20 5 definition definition NN cord-018017-c8myq6bi 20 6 , , , cord-018017-c8myq6bi 20 7 what what WP cord-018017-c8myq6bi 20 8 constitutes constitute VBZ cord-018017-c8myq6bi 20 9 high high JJ cord-018017-c8myq6bi 20 10 impact impact NN cord-018017-c8myq6bi 20 11 ? ? . cord-018017-c8myq6bi 21 1 I -PRON- PRP cord-018017-c8myq6bi 21 2 decided decide VBD cord-018017-c8myq6bi 21 3 to to TO cord-018017-c8myq6bi 21 4 create create VB cord-018017-c8myq6bi 21 5 a a DT cord-018017-c8myq6bi 21 6 definition definition NN cord-018017-c8myq6bi 21 7 that that DT cord-018017-c8myq6bi 21 8 impact impact NN cord-018017-c8myq6bi 21 9 and and CC cord-018017-c8myq6bi 21 10 threat threat NN cord-018017-c8myq6bi 21 11 to to IN cord-018017-c8myq6bi 21 12 life life NN cord-018017-c8myq6bi 21 13 are be VBP cord-018017-c8myq6bi 21 14 related relate VBN cord-018017-c8myq6bi 21 15 . . . cord-018017-c8myq6bi 22 1 Further further RB cord-018017-c8myq6bi 22 2 , , , cord-018017-c8myq6bi 22 3 threat threat NN cord-018017-c8myq6bi 22 4 to to IN cord-018017-c8myq6bi 22 5 human human JJ cord-018017-c8myq6bi 22 6 life life NN cord-018017-c8myq6bi 22 7 is be VBZ cord-018017-c8myq6bi 22 8 the the DT cord-018017-c8myq6bi 22 9 highest high JJS cord-018017-c8myq6bi 22 10 impact impact NN cord-018017-c8myq6bi 22 11 and and CC cord-018017-c8myq6bi 22 12 it -PRON- PRP cord-018017-c8myq6bi 22 13 is be VBZ cord-018017-c8myq6bi 22 14 likely likely JJ cord-018017-c8myq6bi 22 15 that that IN cord-018017-c8myq6bi 22 16 things thing NNS cord-018017-c8myq6bi 22 17 threatening threaten VBG cord-018017-c8myq6bi 22 18 human human JJ cord-018017-c8myq6bi 22 19 life life NN cord-018017-c8myq6bi 22 20 may may MD cord-018017-c8myq6bi 22 21 also also RB cord-018017-c8myq6bi 22 22 threaten threaten VB cord-018017-c8myq6bi 22 23 all all DT cord-018017-c8myq6bi 22 24 life life NN cord-018017-c8myq6bi 22 25 . . . cord-018017-c8myq6bi 23 1 What what WP cord-018017-c8myq6bi 23 2 presents present VBZ cord-018017-c8myq6bi 23 3 the the DT cord-018017-c8myq6bi 23 4 greatest great JJS cord-018017-c8myq6bi 23 5 threat threat NN cord-018017-c8myq6bi 23 6 to to IN cord-018017-c8myq6bi 23 7 human human JJ cord-018017-c8myq6bi 23 8 life life NN cord-018017-c8myq6bi 23 9 today today NN cord-018017-c8myq6bi 23 10 ? ? . cord-018017-c8myq6bi 24 1 History history NN cord-018017-c8myq6bi 24 2 should should MD cord-018017-c8myq6bi 24 3 provide provide VB cord-018017-c8myq6bi 24 4 critical critical JJ cord-018017-c8myq6bi 24 5 insights insight NNS cord-018017-c8myq6bi 24 6 to to TO cord-018017-c8myq6bi 24 7 answer answer VB cord-018017-c8myq6bi 24 8 this this DT cord-018017-c8myq6bi 24 9 question question NN cord-018017-c8myq6bi 24 10 . . . cord-018017-c8myq6bi 25 1 A a DT cord-018017-c8myq6bi 25 2 comprehensive comprehensive JJ cord-018017-c8myq6bi 25 3 look look NN cord-018017-c8myq6bi 25 4 would would MD cord-018017-c8myq6bi 25 5 seek seek VB cord-018017-c8myq6bi 25 6 causes cause NNS cord-018017-c8myq6bi 25 7 of of IN cord-018017-c8myq6bi 25 8 mass mass JJ cord-018017-c8myq6bi 25 9 extinctions extinction NNS cord-018017-c8myq6bi 25 10 over over IN cord-018017-c8myq6bi 25 11 the the DT cord-018017-c8myq6bi 25 12 past past JJ cord-018017-c8myq6bi 25 13 3.5 3.5 CD cord-018017-c8myq6bi 25 14 billion billion CD cord-018017-c8myq6bi 25 15 years year NNS cord-018017-c8myq6bi 25 16 of of IN cord-018017-c8myq6bi 25 17 life life NN cord-018017-c8myq6bi 25 18 on on IN cord-018017-c8myq6bi 25 19 earth earth NN cord-018017-c8myq6bi 25 20 . . . cord-018017-c8myq6bi 26 1 This this DT cord-018017-c8myq6bi 26 2 perspective perspective NN cord-018017-c8myq6bi 26 3 has have VBZ cord-018017-c8myq6bi 26 4 been be VBN cord-018017-c8myq6bi 26 5 a a DT cord-018017-c8myq6bi 26 6 trending trend VBG cord-018017-c8myq6bi 26 7 subject subject NN cord-018017-c8myq6bi 26 8 in in IN cord-018017-c8myq6bi 26 9 science science NN cord-018017-c8myq6bi 26 10 with with IN cord-018017-c8myq6bi 26 11 focus focus NN cord-018017-c8myq6bi 26 12 on on IN cord-018017-c8myq6bi 26 13 five five CD cord-018017-c8myq6bi 26 14 mass mass NN cord-018017-c8myq6bi 26 15 extinctions extinction NNS cord-018017-c8myq6bi 26 16 . . . cord-018017-c8myq6bi 27 1 There there EX cord-018017-c8myq6bi 27 2 are be VBP cord-018017-c8myq6bi 27 3 inherent inherent JJ cord-018017-c8myq6bi 27 4 biases bias NNS cord-018017-c8myq6bi 27 5 in in IN cord-018017-c8myq6bi 27 6 focusing focus VBG cord-018017-c8myq6bi 27 7 on on IN cord-018017-c8myq6bi 27 8 mass mass NN cord-018017-c8myq6bi 27 9 extinctions extinction NNS cord-018017-c8myq6bi 27 10 such such JJ cord-018017-c8myq6bi 27 11 as as IN cord-018017-c8myq6bi 27 12 these these DT cord-018017-c8myq6bi 27 13 events event NNS cord-018017-c8myq6bi 27 14 fail fail VBP cord-018017-c8myq6bi 27 15 to to TO cord-018017-c8myq6bi 27 16 appreciate appreciate VB cord-018017-c8myq6bi 27 17 small small JJ cord-018017-c8myq6bi 27 18 living live VBG cord-018017-c8myq6bi 27 19 things thing NNS cord-018017-c8myq6bi 27 20 such such JJ cord-018017-c8myq6bi 27 21 as as IN cord-018017-c8myq6bi 27 22 single single JJ cord-018017-c8myq6bi 27 23 celled celled JJ cord-018017-c8myq6bi 27 24 organisms organism NNS cord-018017-c8myq6bi 27 25 or or CC cord-018017-c8myq6bi 27 26 bacteria bacteria NNS cord-018017-c8myq6bi 27 27 . . . cord-018017-c8myq6bi 28 1 Another another DT cord-018017-c8myq6bi 28 2 bias bias NN cord-018017-c8myq6bi 28 3 is be VBZ cord-018017-c8myq6bi 28 4 in in IN cord-018017-c8myq6bi 28 5 order order NN cord-018017-c8myq6bi 28 6 to to TO cord-018017-c8myq6bi 28 7 appreciate appreciate VB cord-018017-c8myq6bi 28 8 life life NN cord-018017-c8myq6bi 28 9 in in IN cord-018017-c8myq6bi 28 10 the the DT cord-018017-c8myq6bi 28 11 past past NN cord-018017-c8myq6bi 28 12 , , , cord-018017-c8myq6bi 28 13 the the DT cord-018017-c8myq6bi 28 14 life life NN cord-018017-c8myq6bi 28 15 form form NN cord-018017-c8myq6bi 28 16 must must MD cord-018017-c8myq6bi 28 17 occasionally occasionally RB cord-018017-c8myq6bi 28 18 produce produce VB cord-018017-c8myq6bi 28 19 a a DT cord-018017-c8myq6bi 28 20 fossil fossil NN cord-018017-c8myq6bi 28 21 when when WRB cord-018017-c8myq6bi 28 22 it -PRON- PRP cord-018017-c8myq6bi 28 23 dies die VBZ cord-018017-c8myq6bi 28 24 . . . cord-018017-c8myq6bi 29 1 Those those DT cord-018017-c8myq6bi 29 2 concerns concern NNS cord-018017-c8myq6bi 29 3 aside aside RB cord-018017-c8myq6bi 29 4 - - HYPH cord-018017-c8myq6bi 29 5 geologic geologic JJ cord-018017-c8myq6bi 29 6 events event NNS cord-018017-c8myq6bi 29 7 have have VBP cord-018017-c8myq6bi 29 8 threatened threaten VBN cord-018017-c8myq6bi 29 9 the the DT cord-018017-c8myq6bi 29 10 survival survival NN cord-018017-c8myq6bi 29 11 of of IN cord-018017-c8myq6bi 29 12 living live VBG cord-018017-c8myq6bi 29 13 things thing NNS cord-018017-c8myq6bi 29 14 ( ( -LRB- cord-018017-c8myq6bi 29 15 Table table NN cord-018017-c8myq6bi 29 16 3 3 CD cord-018017-c8myq6bi 29 17 .1 .1 CD cord-018017-c8myq6bi 29 18 ) ) -RRB- cord-018017-c8myq6bi 29 19 . . . cord-018017-c8myq6bi 30 1 The the DT cord-018017-c8myq6bi 30 2 actual actual JJ cord-018017-c8myq6bi 30 3 events event NNS cord-018017-c8myq6bi 30 4 causing cause VBG cord-018017-c8myq6bi 30 5 these these DT cord-018017-c8myq6bi 30 6 extinctions extinction NNS cord-018017-c8myq6bi 30 7 are be VBP cord-018017-c8myq6bi 30 8 frequently frequently RB cord-018017-c8myq6bi 30 9 debated debate VBN cord-018017-c8myq6bi 30 10 , , , cord-018017-c8myq6bi 30 11 for for IN cord-018017-c8myq6bi 30 12 example example NN cord-018017-c8myq6bi 30 13 , , , cord-018017-c8myq6bi 30 14 the the DT cord-018017-c8myq6bi 30 15 asteroid asteroid NN cord-018017-c8myq6bi 30 16 impact impact NN cord-018017-c8myq6bi 30 17 66 66 CD cord-018017-c8myq6bi 30 18 million million CD cord-018017-c8myq6bi 30 19 years year NNS cord-018017-c8myq6bi 30 20 ago ago RB cord-018017-c8myq6bi 30 21 off off IN cord-018017-c8myq6bi 30 22 the the DT cord-018017-c8myq6bi 30 23 coast coast NN cord-018017-c8myq6bi 30 24 of of IN cord-018017-c8myq6bi 30 25 Mexico Mexico NNP cord-018017-c8myq6bi 30 26 was be VBD cord-018017-c8myq6bi 30 27 accompanied accompany VBN cord-018017-c8myq6bi 30 28 by by IN cord-018017-c8myq6bi 30 29 a a DT cord-018017-c8myq6bi 30 30 massive massive JJ cord-018017-c8myq6bi 30 31 tsunami tsunami NN cord-018017-c8myq6bi 30 32 that that WDT cord-018017-c8myq6bi 30 33 was be VBD cord-018017-c8myq6bi 30 34 responsible responsible JJ cord-018017-c8myq6bi 30 35 for for IN cord-018017-c8myq6bi 30 36 mass mass JJ cord-018017-c8myq6bi 30 37 extinctions extinction NNS cord-018017-c8myq6bi 30 38 in in IN cord-018017-c8myq6bi 30 39 Montana Montana NNP cord-018017-c8myq6bi 30 40 , , , cord-018017-c8myq6bi 30 41 the the DT cord-018017-c8myq6bi 30 42 impact impact NN cord-018017-c8myq6bi 30 43 may may MD cord-018017-c8myq6bi 30 44 have have VB cord-018017-c8myq6bi 30 45 also also RB cord-018017-c8myq6bi 30 46 triggered trigger VBN cord-018017-c8myq6bi 30 47 an an DT cord-018017-c8myq6bi 30 48 enormous enormous JJ cord-018017-c8myq6bi 30 49 volcano volcano NN cord-018017-c8myq6bi 30 50 in in IN cord-018017-c8myq6bi 30 51 India India NNP cord-018017-c8myq6bi 30 52 resulting result VBG cord-018017-c8myq6bi 30 53 in in IN cord-018017-c8myq6bi 30 54 ash ash NN cord-018017-c8myq6bi 30 55 and and CC cord-018017-c8myq6bi 30 56 lava lava NN cord-018017-c8myq6bi 30 57 flow flow NN cord-018017-c8myq6bi 30 58 responsible responsible JJ cord-018017-c8myq6bi 30 59 for for IN cord-018017-c8myq6bi 30 60 regional regional JJ cord-018017-c8myq6bi 30 61 species species NN cord-018017-c8myq6bi 30 62 extinctions extinction NNS cord-018017-c8myq6bi 30 63 , , , cord-018017-c8myq6bi 30 64 and and CC cord-018017-c8myq6bi 30 65 the the DT cord-018017-c8myq6bi 30 66 collective collective JJ cord-018017-c8myq6bi 30 67 dust dust NN cord-018017-c8myq6bi 30 68 resulted result VBD cord-018017-c8myq6bi 30 69 in in IN cord-018017-c8myq6bi 30 70 prolonged prolong VBN cord-018017-c8myq6bi 30 71 climate climate NN cord-018017-c8myq6bi 30 72 change change NN cord-018017-c8myq6bi 30 73 which which WDT cord-018017-c8myq6bi 30 74 was be VBD cord-018017-c8myq6bi 30 75 probably probably RB cord-018017-c8myq6bi 30 76 responsible responsible JJ cord-018017-c8myq6bi 30 77 for for IN cord-018017-c8myq6bi 30 78 even even RB cord-018017-c8myq6bi 30 79 more more JJR cord-018017-c8myq6bi 30 80 species species NN cord-018017-c8myq6bi 30 81 extinctions extinction NNS cord-018017-c8myq6bi 30 82 . . . cord-018017-c8myq6bi 31 1 The the DT cord-018017-c8myq6bi 31 2 lesson lesson NN cord-018017-c8myq6bi 31 3 remains remain VBZ cord-018017-c8myq6bi 31 4 the the DT cord-018017-c8myq6bi 31 5 same same JJ cord-018017-c8myq6bi 31 6 , , , cord-018017-c8myq6bi 31 7 volcanic volcanic JJ cord-018017-c8myq6bi 31 8 eruptions eruption NNS cord-018017-c8myq6bi 31 9 ; ; : cord-018017-c8myq6bi 31 10 climate climate NN cord-018017-c8myq6bi 31 11 change change NN cord-018017-c8myq6bi 31 12 and and CC cord-018017-c8myq6bi 31 13 asteroid asteroid NN cord-018017-c8myq6bi 31 14 impact impact NN cord-018017-c8myq6bi 31 15 threaten threaten VBP cord-018017-c8myq6bi 31 16 life life NN cord-018017-c8myq6bi 31 17 in in IN cord-018017-c8myq6bi 31 18 a a DT cord-018017-c8myq6bi 31 19 highly highly RB cord-018017-c8myq6bi 31 20 significant significant JJ cord-018017-c8myq6bi 31 21 way way NN cord-018017-c8myq6bi 31 22 and and CC cord-018017-c8myq6bi 31 23 are be VBP cord-018017-c8myq6bi 31 24 responsible responsible JJ cord-018017-c8myq6bi 31 25 for for IN cord-018017-c8myq6bi 31 26 extensive extensive JJ cord-018017-c8myq6bi 31 27 selection selection NN cord-018017-c8myq6bi 31 28 pressure pressure NN cord-018017-c8myq6bi 31 29 . . . cord-018017-c8myq6bi 32 1 Unfortunately unfortunately RB cord-018017-c8myq6bi 32 2 , , , cord-018017-c8myq6bi 32 3 these these DT cord-018017-c8myq6bi 32 4 events event NNS cord-018017-c8myq6bi 32 5 are be VBP cord-018017-c8myq6bi 32 6 unpredictable unpredictable JJ cord-018017-c8myq6bi 32 7 and and CC cord-018017-c8myq6bi 32 8 so so RB cord-018017-c8myq6bi 32 9 enormous enormous JJ cord-018017-c8myq6bi 32 10 little little JJ cord-018017-c8myq6bi 32 11 can can MD cord-018017-c8myq6bi 32 12 be be VB cord-018017-c8myq6bi 32 13 done do VBN cord-018017-c8myq6bi 32 14 about about IN cord-018017-c8myq6bi 32 15 them -PRON- PRP cord-018017-c8myq6bi 32 16 . . . cord-018017-c8myq6bi 33 1 A a DT cord-018017-c8myq6bi 33 2 mass mass JJ cord-018017-c8myq6bi 33 3 extinction extinction NN cord-018017-c8myq6bi 33 4 may may MD cord-018017-c8myq6bi 33 5 not not RB cord-018017-c8myq6bi 33 6 represent represent VB cord-018017-c8myq6bi 33 7 a a DT cord-018017-c8myq6bi 33 8 legitimate legitimate JJ cord-018017-c8myq6bi 33 9 threat threat NN cord-018017-c8myq6bi 33 10 or or CC cord-018017-c8myq6bi 33 11 selection selection NN cord-018017-c8myq6bi 33 12 pressure pressure NN cord-018017-c8myq6bi 33 13 because because IN cord-018017-c8myq6bi 33 14 large large JJ cord-018017-c8myq6bi 33 15 numbers number NNS cord-018017-c8myq6bi 33 16 of of IN cord-018017-c8myq6bi 33 17 species specie NNS cord-018017-c8myq6bi 33 18 are be VBP cord-018017-c8myq6bi 33 19 completely completely RB cord-018017-c8myq6bi 33 20 eradicated eradicate VBN cord-018017-c8myq6bi 33 21 leaving leave VBG cord-018017-c8myq6bi 33 22 few few JJ cord-018017-c8myq6bi 33 23 survivors survivor NNS cord-018017-c8myq6bi 33 24 to to TO cord-018017-c8myq6bi 33 25 drive drive VB cord-018017-c8myq6bi 33 26 evolution evolution NN cord-018017-c8myq6bi 33 27 . . . cord-018017-c8myq6bi 34 1 Finally finally RB cord-018017-c8myq6bi 34 2 , , , cord-018017-c8myq6bi 34 3 outside outside RB cord-018017-c8myq6bi 34 4 of of IN cord-018017-c8myq6bi 34 5 removing remove VBG cord-018017-c8myq6bi 34 6 dinosaurs dinosaur NNS cord-018017-c8myq6bi 34 7 so so IN cord-018017-c8myq6bi 34 8 that that IN cord-018017-c8myq6bi 34 9 mammals mammal NNS cord-018017-c8myq6bi 34 10 could could MD cord-018017-c8myq6bi 34 11 thrive thrive VB cord-018017-c8myq6bi 34 12 , , , cord-018017-c8myq6bi 34 13 what what WDT cord-018017-c8myq6bi 34 14 impact impact NN cord-018017-c8myq6bi 34 15 did do VBD cord-018017-c8myq6bi 34 16 these these DT cord-018017-c8myq6bi 34 17 events event NNS cord-018017-c8myq6bi 34 18 have have VB cord-018017-c8myq6bi 34 19 on on IN cord-018017-c8myq6bi 34 20 human human JJ cord-018017-c8myq6bi 34 21 life life NN cord-018017-c8myq6bi 34 22 ; ; : cord-018017-c8myq6bi 34 23 humans human NNS cord-018017-c8myq6bi 34 24 were be VBD cord-018017-c8myq6bi 34 25 not not RB cord-018017-c8myq6bi 34 26 yet yet RB cord-018017-c8myq6bi 34 27 on on IN cord-018017-c8myq6bi 34 28 the the DT cord-018017-c8myq6bi 34 29 earth earth NN cord-018017-c8myq6bi 34 30 when when WRB cord-018017-c8myq6bi 34 31 these these DT cord-018017-c8myq6bi 34 32 events event NNS cord-018017-c8myq6bi 34 33 took take VBD cord-018017-c8myq6bi 34 34 place place NN cord-018017-c8myq6bi 34 35 . . . cord-018017-c8myq6bi 35 1 Refining refine VBG cord-018017-c8myq6bi 35 2 the the DT cord-018017-c8myq6bi 35 3 search search NN cord-018017-c8myq6bi 35 4 to to IN cord-018017-c8myq6bi 35 5 dramatic dramatic JJ cord-018017-c8myq6bi 35 6 changes change NNS cord-018017-c8myq6bi 35 7 in in IN cord-018017-c8myq6bi 35 8 human human JJ cord-018017-c8myq6bi 35 9 populations population NNS cord-018017-c8myq6bi 35 10 moves move VBZ cord-018017-c8myq6bi 35 11 the the DT cord-018017-c8myq6bi 35 12 period period NN cord-018017-c8myq6bi 35 13 up up IN cord-018017-c8myq6bi 35 14 to to IN cord-018017-c8myq6bi 35 15 the the DT cord-018017-c8myq6bi 35 16 last last JJ cord-018017-c8myq6bi 35 17 100,000 100,000 CD cord-018017-c8myq6bi 35 18 years year NNS cord-018017-c8myq6bi 35 19 . . . cord-018017-c8myq6bi 36 1 Mass mass JJ cord-018017-c8myq6bi 36 2 migrations migration NNS cord-018017-c8myq6bi 36 3 took take VBD cord-018017-c8myq6bi 36 4 place place NN cord-018017-c8myq6bi 36 5 about about RB cord-018017-c8myq6bi 36 6 every every DT cord-018017-c8myq6bi 36 7 23,000 23,000 CD cord-018017-c8myq6bi 36 8 years year NNS cord-018017-c8myq6bi 36 9 , , , cord-018017-c8myq6bi 36 10 which which WDT cord-018017-c8myq6bi 36 11 is be VBZ cord-018017-c8myq6bi 36 12 in in IN cord-018017-c8myq6bi 36 13 line line NN cord-018017-c8myq6bi 36 14 with with IN cord-018017-c8myq6bi 36 15 the the DT cord-018017-c8myq6bi 36 16 precession precession NN cord-018017-c8myq6bi 36 17 of of IN cord-018017-c8myq6bi 36 18 the the DT cord-018017-c8myq6bi 36 19 earth earth NN cord-018017-c8myq6bi 36 20 leading lead VBG cord-018017-c8myq6bi 36 21 to to IN cord-018017-c8myq6bi 36 22 a a DT cord-018017-c8myq6bi 36 23 possible possible JJ cord-018017-c8myq6bi 36 24 linkage linkage NN cord-018017-c8myq6bi 36 25 between between IN cord-018017-c8myq6bi 36 26 earth earth NN cord-018017-c8myq6bi 36 27 's 's POS cord-018017-c8myq6bi 36 28 precession precession NN cord-018017-c8myq6bi 36 29 and and CC cord-018017-c8myq6bi 36 30 human human JJ cord-018017-c8myq6bi 36 31 migration migration NN cord-018017-c8myq6bi 36 32 . . . cord-018017-c8myq6bi 37 1 This this DT cord-018017-c8myq6bi 37 2 may may MD cord-018017-c8myq6bi 37 3 have have VB cord-018017-c8myq6bi 37 4 been be VBN cord-018017-c8myq6bi 37 5 due due JJ cord-018017-c8myq6bi 37 6 to to IN cord-018017-c8myq6bi 37 7 regional regional JJ cord-018017-c8myq6bi 37 8 climate climate NN cord-018017-c8myq6bi 37 9 change change NN cord-018017-c8myq6bi 37 10 like like IN cord-018017-c8myq6bi 37 11 ice ice NN cord-018017-c8myq6bi 37 12 ages age NNS cord-018017-c8myq6bi 37 13 in in IN cord-018017-c8myq6bi 37 14 the the DT cord-018017-c8myq6bi 37 15 northern northern JJ cord-018017-c8myq6bi 37 16 hemisphere hemisphere NN cord-018017-c8myq6bi 37 17 . . . cord-018017-c8myq6bi 38 1 However however RB cord-018017-c8myq6bi 38 2 , , , cord-018017-c8myq6bi 38 3 human human JJ cord-018017-c8myq6bi 38 4 population population NN cord-018017-c8myq6bi 38 5 changes change VBZ cord-018017-c8myq6bi 38 6 on on IN cord-018017-c8myq6bi 38 7 this this DT cord-018017-c8myq6bi 38 8 timescale timescale NN cord-018017-c8myq6bi 38 9 are be VBP cord-018017-c8myq6bi 38 10 not not RB cord-018017-c8myq6bi 38 11 easily easily RB cord-018017-c8myq6bi 38 12 documented document VBN cord-018017-c8myq6bi 38 13 so so IN cord-018017-c8myq6bi 38 14 estimates estimate NNS cord-018017-c8myq6bi 38 15 of of IN cord-018017-c8myq6bi 38 16 climate climate NN cord-018017-c8myq6bi 38 17 and and CC cord-018017-c8myq6bi 38 18 human human JJ cord-018017-c8myq6bi 38 19 population population NN cord-018017-c8myq6bi 38 20 dynamics dynamic NNS cord-018017-c8myq6bi 38 21 will will MD cord-018017-c8myq6bi 38 22 be be VB cord-018017-c8myq6bi 38 23 limited limit VBN cord-018017-c8myq6bi 38 24 . . . cord-018017-c8myq6bi 39 1 Time time NN cord-018017-c8myq6bi 39 2 to to TO cord-018017-c8myq6bi 39 3 refine refine VB cord-018017-c8myq6bi 39 4 the the DT cord-018017-c8myq6bi 39 5 search search NN cord-018017-c8myq6bi 39 6 . . . cord-018017-c8myq6bi 40 1 Consider consider VB cord-018017-c8myq6bi 40 2 the the DT cord-018017-c8myq6bi 40 3 exponential exponential JJ cord-018017-c8myq6bi 40 4 growth growth NN cord-018017-c8myq6bi 40 5 , , , cord-018017-c8myq6bi 40 6 outbreak outbreak NN cord-018017-c8myq6bi 40 7 , , , cord-018017-c8myq6bi 40 8 of of IN cord-018017-c8myq6bi 40 9 tent tent NN cord-018017-c8myq6bi 40 10 caterpillars caterpillar NNS cord-018017-c8myq6bi 40 11 , , , cord-018017-c8myq6bi 40 12 Malacosoma Malacosoma NNP cord-018017-c8myq6bi 40 13 disstria disstria NNP cord-018017-c8myq6bi 40 14 , , , cord-018017-c8myq6bi 40 15 in in IN cord-018017-c8myq6bi 40 16 Montana Montana NNP cord-018017-c8myq6bi 40 17 reported report VBN cord-018017-c8myq6bi 40 18 by by IN cord-018017-c8myq6bi 40 19 David David NNP cord-018017-c8myq6bi 40 20 Quammen Quammen NNP cord-018017-c8myq6bi 40 21 in in IN cord-018017-c8myq6bi 40 22 his -PRON- PRP$ cord-018017-c8myq6bi 40 23 book book NN cord-018017-c8myq6bi 40 24 Spillover Spillover NNP cord-018017-c8myq6bi 40 25 ( ( -LRB- cord-018017-c8myq6bi 40 26 Quammen Quammen NNP cord-018017-c8myq6bi 40 27 2012 2012 CD cord-018017-c8myq6bi 40 28 ) ) -RRB- cord-018017-c8myq6bi 40 29 . . . cord-018017-c8myq6bi 41 1 The the DT cord-018017-c8myq6bi 41 2 extensive extensive JJ cord-018017-c8myq6bi 41 3 caterpillar caterpillar NN cord-018017-c8myq6bi 41 4 population population NN cord-018017-c8myq6bi 41 5 consumed consume VBD cord-018017-c8myq6bi 41 6 all all DT cord-018017-c8myq6bi 41 7 of of IN cord-018017-c8myq6bi 41 8 the the DT cord-018017-c8myq6bi 41 9 leaves leave NNS cord-018017-c8myq6bi 41 10 from from IN cord-018017-c8myq6bi 41 11 the the DT cord-018017-c8myq6bi 41 12 local local JJ cord-018017-c8myq6bi 41 13 elm elm NN cord-018017-c8myq6bi 41 14 and and CC cord-018017-c8myq6bi 41 15 cottonwood cottonwood NN cord-018017-c8myq6bi 41 16 trees tree NNS cord-018017-c8myq6bi 41 17 in in IN cord-018017-c8myq6bi 41 18 the the DT cord-018017-c8myq6bi 41 19 summer summer NN cord-018017-c8myq6bi 41 20 of of IN cord-018017-c8myq6bi 41 21 1993 1993 CD cord-018017-c8myq6bi 41 22 . . . cord-018017-c8myq6bi 42 1 The the DT cord-018017-c8myq6bi 42 2 caterpillar caterpillar NN cord-018017-c8myq6bi 42 3 activity activity NN cord-018017-c8myq6bi 42 4 produced produce VBD cord-018017-c8myq6bi 42 5 a a DT cord-018017-c8myq6bi 42 6 crackle crackle NN cord-018017-c8myq6bi 42 7 sound sound NN cord-018017-c8myq6bi 42 8 , , , cord-018017-c8myq6bi 42 9 " " '' cord-018017-c8myq6bi 42 10 like like IN cord-018017-c8myq6bi 42 11 a a DT cord-018017-c8myq6bi 42 12 distant distant JJ cord-018017-c8myq6bi 42 13 brushfire brushfire NN cord-018017-c8myq6bi 42 14 . . . cord-018017-c8myq6bi 43 1 " " `` cord-018017-c8myq6bi 43 2 The the DT cord-018017-c8myq6bi 43 3 city city NN cord-018017-c8myq6bi 43 4 attacked attack VBD cord-018017-c8myq6bi 43 5 these these DT cord-018017-c8myq6bi 43 6 insects insect NNS cord-018017-c8myq6bi 43 7 with with IN cord-018017-c8myq6bi 43 8 a a DT cord-018017-c8myq6bi 43 9 broad broad JJ cord-018017-c8myq6bi 43 10 arsenal arsenal NN cord-018017-c8myq6bi 43 11 of of IN cord-018017-c8myq6bi 43 12 modern modern JJ cord-018017-c8myq6bi 43 13 countermeasures countermeasure NNS cord-018017-c8myq6bi 43 14 but but CC cord-018017-c8myq6bi 43 15 to to IN cord-018017-c8myq6bi 43 16 no no DT cord-018017-c8myq6bi 43 17 effect effect NN cord-018017-c8myq6bi 43 18 . . . cord-018017-c8myq6bi 44 1 However however RB cord-018017-c8myq6bi 44 2 , , , cord-018017-c8myq6bi 44 3 a a DT cord-018017-c8myq6bi 44 4 nuclear nuclear JJ cord-018017-c8myq6bi 44 5 polyhedrosis polyhedrosis NN cord-018017-c8myq6bi 44 6 virus virus NN cord-018017-c8myq6bi 44 7 ( ( -LRB- cord-018017-c8myq6bi 44 8 NPV NPV NNP cord-018017-c8myq6bi 44 9 ) ) -RRB- cord-018017-c8myq6bi 44 10 , , , cord-018017-c8myq6bi 44 11 uses use VBZ cord-018017-c8myq6bi 44 12 the the DT cord-018017-c8myq6bi 44 13 caterpillar caterpillar NN cord-018017-c8myq6bi 44 14 host host NN cord-018017-c8myq6bi 44 15 density density NN cord-018017-c8myq6bi 44 16 like like IN cord-018017-c8myq6bi 44 17 a a DT cord-018017-c8myq6bi 44 18 critical critical JJ cord-018017-c8myq6bi 44 19 mass mass NN cord-018017-c8myq6bi 44 20 in in IN cord-018017-c8myq6bi 44 21 a a DT cord-018017-c8myq6bi 44 22 nuclear nuclear JJ cord-018017-c8myq6bi 44 23 weapon weapon NN cord-018017-c8myq6bi 44 24 to to TO cord-018017-c8myq6bi 44 25 explode explode VB cord-018017-c8myq6bi 44 26 destroying destroy VBG cord-018017-c8myq6bi 44 27 the the DT cord-018017-c8myq6bi 44 28 caterpillars caterpillar NNS cord-018017-c8myq6bi 44 29 in in IN cord-018017-c8myq6bi 44 30 an an DT cord-018017-c8myq6bi 44 31 epic epic JJ cord-018017-c8myq6bi 44 32 battle battle NN cord-018017-c8myq6bi 44 33 . . . cord-018017-c8myq6bi 45 1 The the DT cord-018017-c8myq6bi 45 2 caterpillar caterpillar NN cord-018017-c8myq6bi 45 3 population population NN cord-018017-c8myq6bi 45 4 retreated retreat VBD cord-018017-c8myq6bi 45 5 to to IN cord-018017-c8myq6bi 45 6 undetectable undetectable JJ cord-018017-c8myq6bi 45 7 levels level NNS cord-018017-c8myq6bi 45 8 in in IN cord-018017-c8myq6bi 45 9 a a DT cord-018017-c8myq6bi 45 10 single single JJ cord-018017-c8myq6bi 45 11 season season NN cord-018017-c8myq6bi 45 12 as as IN cord-018017-c8myq6bi 45 13 a a DT cord-018017-c8myq6bi 45 14 result result NN cord-018017-c8myq6bi 45 15 of of IN cord-018017-c8myq6bi 45 16 NPV NPV NNP cord-018017-c8myq6bi 45 17 . . . cord-018017-c8myq6bi 46 1 Human human JJ cord-018017-c8myq6bi 46 2 populations population NNS cord-018017-c8myq6bi 46 3 changed change VBD cord-018017-c8myq6bi 46 4 over over IN cord-018017-c8myq6bi 46 5 the the DT cord-018017-c8myq6bi 46 6 past past JJ cord-018017-c8myq6bi 46 7 20,000 20,000 CD cord-018017-c8myq6bi 46 8 years year NNS cord-018017-c8myq6bi 46 9 with with IN cord-018017-c8myq6bi 46 10 particular particular JJ cord-018017-c8myq6bi 46 11 emphasis emphasis NN cord-018017-c8myq6bi 46 12 on on IN cord-018017-c8myq6bi 46 13 the the DT cord-018017-c8myq6bi 46 14 most most RBS cord-018017-c8myq6bi 46 15 recent recent JJ cord-018017-c8myq6bi 46 16 7000 7000 CD cord-018017-c8myq6bi 46 17 years year NNS cord-018017-c8myq6bi 46 18 . . . cord-018017-c8myq6bi 47 1 A a DT cord-018017-c8myq6bi 47 2 human human JJ cord-018017-c8myq6bi 47 3 population population NN cord-018017-c8myq6bi 47 4 curve curve NN cord-018017-c8myq6bi 47 5 over over IN cord-018017-c8myq6bi 47 6 this this DT cord-018017-c8myq6bi 47 7 segment segment NN cord-018017-c8myq6bi 47 8 of of IN cord-018017-c8myq6bi 47 9 time time NN cord-018017-c8myq6bi 47 10 shows show VBZ cord-018017-c8myq6bi 47 11 an an DT cord-018017-c8myq6bi 47 12 exponential exponential JJ cord-018017-c8myq6bi 47 13 growth growth NN cord-018017-c8myq6bi 47 14 period period NN cord-018017-c8myq6bi 47 15 interrupted interrupt VBN cord-018017-c8myq6bi 47 16 in in IN cord-018017-c8myq6bi 47 17 the the DT cord-018017-c8myq6bi 47 18 middle middle JJ cord-018017-c8myq6bi 47 19 ages age NNS cord-018017-c8myq6bi 47 20 by by IN cord-018017-c8myq6bi 47 21 the the DT cord-018017-c8myq6bi 47 22 plague plague NN cord-018017-c8myq6bi 47 23 . . . cord-018017-c8myq6bi 48 1 Hypothesis hypothesis NN cord-018017-c8myq6bi 48 2 : : : cord-018017-c8myq6bi 49 1 The the DT cord-018017-c8myq6bi 49 2 plague plague NN cord-018017-c8myq6bi 49 3 and and CC cord-018017-c8myq6bi 49 4 other other JJ cord-018017-c8myq6bi 49 5 pandemic pandemic NN cord-018017-c8myq6bi 49 6 infectious infectious JJ cord-018017-c8myq6bi 49 7 disease disease NN cord-018017-c8myq6bi 49 8 events event NNS cord-018017-c8myq6bi 49 9 appear appear VBP cord-018017-c8myq6bi 49 10 to to TO cord-018017-c8myq6bi 49 11 be be VB cord-018017-c8myq6bi 49 12 the the DT cord-018017-c8myq6bi 49 13 greatest great JJS cord-018017-c8myq6bi 49 14 threat threat NN cord-018017-c8myq6bi 49 15 to to IN cord-018017-c8myq6bi 49 16 human human JJ cord-018017-c8myq6bi 49 17 life life NN cord-018017-c8myq6bi 49 18 . . . cord-018017-c8myq6bi 50 1 Infectious infectious JJ cord-018017-c8myq6bi 50 2 disease disease NN cord-018017-c8myq6bi 50 3 kills kill VBZ cord-018017-c8myq6bi 50 4 15 15 CD cord-018017-c8myq6bi 50 5 million million CD cord-018017-c8myq6bi 50 6 people people NNS cord-018017-c8myq6bi 50 7 each each DT cord-018017-c8myq6bi 50 8 year year NN cord-018017-c8myq6bi 50 9 , , , cord-018017-c8myq6bi 50 10 26 26 CD cord-018017-c8myq6bi 50 11 percent percent NN cord-018017-c8myq6bi 50 12 of of IN cord-018017-c8myq6bi 50 13 the the DT cord-018017-c8myq6bi 50 14 total total JJ cord-018017-c8myq6bi 50 15 57 57 CD cord-018017-c8myq6bi 50 16 million million CD cord-018017-c8myq6bi 50 17 annual annual JJ cord-018017-c8myq6bi 50 18 deaths death NNS cord-018017-c8myq6bi 50 19 in in IN cord-018017-c8myq6bi 50 20 the the DT cord-018017-c8myq6bi 50 21 global global JJ cord-018017-c8myq6bi 50 22 population population NN cord-018017-c8myq6bi 50 23 ( ( -LRB- cord-018017-c8myq6bi 50 24 Fauci Fauci NNP cord-018017-c8myq6bi 50 25 and and CC cord-018017-c8myq6bi 50 26 Morens Morens NNP cord-018017-c8myq6bi 50 27 2012 2012 CD cord-018017-c8myq6bi 50 28 ) ) -RRB- cord-018017-c8myq6bi 50 29 . . . cord-018017-c8myq6bi 51 1 A a DT cord-018017-c8myq6bi 51 2 brief brief JJ cord-018017-c8myq6bi 51 3 review review NN cord-018017-c8myq6bi 51 4 of of IN cord-018017-c8myq6bi 51 5 pandemic pandemic JJ cord-018017-c8myq6bi 51 6 infections infection NNS cord-018017-c8myq6bi 51 7 over over IN cord-018017-c8myq6bi 51 8 the the DT cord-018017-c8myq6bi 51 9 past past JJ cord-018017-c8myq6bi 51 10 3000 3000 CD cord-018017-c8myq6bi 51 11 years year NNS cord-018017-c8myq6bi 51 12 illuminates illuminate VBZ cord-018017-c8myq6bi 51 13 several several JJ cord-018017-c8myq6bi 51 14 events event NNS cord-018017-c8myq6bi 51 15 that that WDT cord-018017-c8myq6bi 51 16 reduced reduce VBD cord-018017-c8myq6bi 51 17 human human JJ cord-018017-c8myq6bi 51 18 populations population NNS cord-018017-c8myq6bi 51 19 . . . cord-018017-c8myq6bi 52 1 The the DT cord-018017-c8myq6bi 52 2 plague plague NN cord-018017-c8myq6bi 52 3 of of IN cord-018017-c8myq6bi 52 4 Athens Athens NNP cord-018017-c8myq6bi 52 5 430 430 CD cord-018017-c8myq6bi 52 6 BCE BCE NNP cord-018017-c8myq6bi 52 7 killed kill VBD cord-018017-c8myq6bi 52 8 25 25 CD cord-018017-c8myq6bi 52 9 percent percent NN cord-018017-c8myq6bi 52 10 of of IN cord-018017-c8myq6bi 52 11 the the DT cord-018017-c8myq6bi 52 12 human human JJ cord-018017-c8myq6bi 52 13 population population NN cord-018017-c8myq6bi 52 14 ( ( -LRB- cord-018017-c8myq6bi 52 15 Table Table NNP cord-018017-c8myq6bi 52 16 3 3 CD cord-018017-c8myq6bi 52 17 .2 .2 CD cord-018017-c8myq6bi 52 18 ) ) -RRB- cord-018017-c8myq6bi 52 19 . . . cord-018017-c8myq6bi 53 1 Both both DT cord-018017-c8myq6bi 53 2 bacterial bacterial JJ cord-018017-c8myq6bi 53 3 and and CC cord-018017-c8myq6bi 53 4 viral viral JJ cord-018017-c8myq6bi 53 5 pandemic pandemic NN cord-018017-c8myq6bi 53 6 Yersinia Yersinia NNP cord-018017-c8myq6bi 53 7 pestis pestis NN cord-018017-c8myq6bi 53 8 is be VBZ cord-018017-c8myq6bi 53 9 a a DT cord-018017-c8myq6bi 53 10 bacterium bacterium NN cord-018017-c8myq6bi 53 11 causing cause VBG cord-018017-c8myq6bi 53 12 plague plague NN cord-018017-c8myq6bi 53 13 . . . cord-018017-c8myq6bi 54 1 Fleas flea NNS cord-018017-c8myq6bi 54 2 can can MD cord-018017-c8myq6bi 54 3 be be VB cord-018017-c8myq6bi 54 4 infected infect VBN cord-018017-c8myq6bi 54 5 with with IN cord-018017-c8myq6bi 54 6 Y Y NNP cord-018017-c8myq6bi 54 7 pestis pestis NN cord-018017-c8myq6bi 54 8 which which WDT cord-018017-c8myq6bi 54 9 transmit transmit VBP cord-018017-c8myq6bi 54 10 the the DT cord-018017-c8myq6bi 54 11 bacterium bacterium NN cord-018017-c8myq6bi 54 12 to to IN cord-018017-c8myq6bi 54 13 rodents rodent NNS cord-018017-c8myq6bi 54 14 , , , cord-018017-c8myq6bi 54 15 the the DT cord-018017-c8myq6bi 54 16 primary primary JJ cord-018017-c8myq6bi 54 17 hosts host NNS cord-018017-c8myq6bi 54 18 . . . cord-018017-c8myq6bi 55 1 Changes change NNS cord-018017-c8myq6bi 55 2 in in IN cord-018017-c8myq6bi 55 3 the the DT cord-018017-c8myq6bi 55 4 environment environment NN cord-018017-c8myq6bi 55 5 may may MD cord-018017-c8myq6bi 55 6 lead lead VB cord-018017-c8myq6bi 55 7 to to IN cord-018017-c8myq6bi 55 8 the the DT cord-018017-c8myq6bi 55 9 movement movement NN cord-018017-c8myq6bi 55 10 of of IN cord-018017-c8myq6bi 55 11 rats rat NNS cord-018017-c8myq6bi 55 12 into into IN cord-018017-c8myq6bi 55 13 populated populated JJ cord-018017-c8myq6bi 55 14 areas area NNS cord-018017-c8myq6bi 55 15 where where WRB cord-018017-c8myq6bi 55 16 humans human NNS cord-018017-c8myq6bi 55 17 become become VBP cord-018017-c8myq6bi 55 18 infected infected JJ cord-018017-c8myq6bi 55 19 . . . cord-018017-c8myq6bi 56 1 Homer Homer NNP cord-018017-c8myq6bi 56 2 points point NNS cord-018017-c8myq6bi 56 3 to to IN cord-018017-c8myq6bi 56 4 such such PDT cord-018017-c8myq6bi 56 5 an an DT cord-018017-c8myq6bi 56 6 infection infection NN cord-018017-c8myq6bi 56 7 in in IN cord-018017-c8myq6bi 56 8 the the DT cord-018017-c8myq6bi 56 9 Iliad Iliad NNP cord-018017-c8myq6bi 56 10 in in IN cord-018017-c8myq6bi 56 11 his -PRON- PRP$ cord-018017-c8myq6bi 56 12 description description NN cord-018017-c8myq6bi 56 13 of of IN cord-018017-c8myq6bi 56 14 the the DT cord-018017-c8myq6bi 56 15 Trojan Trojan NNP cord-018017-c8myq6bi 56 16 War War NNP cord-018017-c8myq6bi 56 17 in in IN cord-018017-c8myq6bi 56 18 1190 1190 CD cord-018017-c8myq6bi 56 19 BCE BCE NNP cord-018017-c8myq6bi 56 20 . . . cord-018017-c8myq6bi 57 1 Plague plague NN cord-018017-c8myq6bi 57 2 has have VBZ cord-018017-c8myq6bi 57 3 returned return VBN cord-018017-c8myq6bi 57 4 several several JJ cord-018017-c8myq6bi 57 5 times time NNS cord-018017-c8myq6bi 57 6 since since IN cord-018017-c8myq6bi 57 7 the the DT cord-018017-c8myq6bi 57 8 Trojan Trojan NNP cord-018017-c8myq6bi 57 9 War War NNP cord-018017-c8myq6bi 57 10 imposing impose VBG cord-018017-c8myq6bi 57 11 enormous enormous JJ cord-018017-c8myq6bi 57 12 loss loss NN cord-018017-c8myq6bi 57 13 of of IN cord-018017-c8myq6bi 57 14 human human JJ cord-018017-c8myq6bi 57 15 life life NN cord-018017-c8myq6bi 57 16 ( ( -LRB- cord-018017-c8myq6bi 57 17 Table table NN cord-018017-c8myq6bi 57 18 3 3 CD cord-018017-c8myq6bi 57 19 .2 .2 CD cord-018017-c8myq6bi 57 20 ) ) -RRB- cord-018017-c8myq6bi 57 21 . . . cord-018017-c8myq6bi 58 1 The the DT cord-018017-c8myq6bi 58 2 most most RBS cord-018017-c8myq6bi 58 3 recent recent JJ cord-018017-c8myq6bi 58 4 plague plague NN cord-018017-c8myq6bi 58 5 epidemic epidemic NN cord-018017-c8myq6bi 58 6 killed kill VBN cord-018017-c8myq6bi 58 7 over over IN cord-018017-c8myq6bi 58 8 ten ten CD cord-018017-c8myq6bi 58 9 million million CD cord-018017-c8myq6bi 58 10 people people NNS cord-018017-c8myq6bi 58 11 in in IN cord-018017-c8myq6bi 58 12 India India NNP cord-018017-c8myq6bi 58 13 in in IN cord-018017-c8myq6bi 58 14 the the DT cord-018017-c8myq6bi 58 15 early early JJ cord-018017-c8myq6bi 58 16 20th 20th JJ cord-018017-c8myq6bi 58 17 century century NN cord-018017-c8myq6bi 58 18 . . . cord-018017-c8myq6bi 59 1 Y Y NNP cord-018017-c8myq6bi 59 2 pestis pestis NN cord-018017-c8myq6bi 59 3 is be VBZ cord-018017-c8myq6bi 59 4 still still RB cord-018017-c8myq6bi 59 5 out out RB cord-018017-c8myq6bi 59 6 there there RB cord-018017-c8myq6bi 59 7 ready ready JJ cord-018017-c8myq6bi 59 8 for for IN cord-018017-c8myq6bi 59 9 favorable favorable JJ cord-018017-c8myq6bi 59 10 conditions condition NNS cord-018017-c8myq6bi 59 11 to to TO cord-018017-c8myq6bi 59 12 pounce pounce VB cord-018017-c8myq6bi 59 13 on on IN cord-018017-c8myq6bi 59 14 human human JJ cord-018017-c8myq6bi 59 15 populations population NNS cord-018017-c8myq6bi 59 16 but but CC cord-018017-c8myq6bi 59 17 outcomes outcome NNS cord-018017-c8myq6bi 59 18 are be VBP cord-018017-c8myq6bi 59 19 likely likely JJ cord-018017-c8myq6bi 59 20 to to TO cord-018017-c8myq6bi 59 21 be be VB cord-018017-c8myq6bi 59 22 less less RBR cord-018017-c8myq6bi 59 23 dramatic dramatic JJ cord-018017-c8myq6bi 59 24 due due IN cord-018017-c8myq6bi 59 25 to to IN cord-018017-c8myq6bi 59 26 understanding understanding NN cord-018017-c8myq6bi 59 27 of of IN cord-018017-c8myq6bi 59 28 sanitation sanitation NN cord-018017-c8myq6bi 59 29 practices practice NNS cord-018017-c8myq6bi 59 30 , , , cord-018017-c8myq6bi 59 31 quarantine quarantine NN cord-018017-c8myq6bi 59 32 , , , cord-018017-c8myq6bi 59 33 and and CC cord-018017-c8myq6bi 59 34 availability availability NN cord-018017-c8myq6bi 59 35 of of IN cord-018017-c8myq6bi 59 36 antibiotics antibiotic NNS cord-018017-c8myq6bi 59 37 . . . cord-018017-c8myq6bi 60 1 If if IN cord-018017-c8myq6bi 60 2 infections infection NNS cord-018017-c8myq6bi 60 3 are be VBP cord-018017-c8myq6bi 60 4 the the DT cord-018017-c8myq6bi 60 5 greatest great JJS cord-018017-c8myq6bi 60 6 threat threat NN cord-018017-c8myq6bi 60 7 to to IN cord-018017-c8myq6bi 60 8 human human JJ cord-018017-c8myq6bi 60 9 life life NN cord-018017-c8myq6bi 60 10 , , , cord-018017-c8myq6bi 60 11 they -PRON- PRP cord-018017-c8myq6bi 60 12 should should MD cord-018017-c8myq6bi 60 13 be be VB cord-018017-c8myq6bi 60 14 critical critical JJ cord-018017-c8myq6bi 60 15 drivers driver NNS cord-018017-c8myq6bi 60 16 of of IN cord-018017-c8myq6bi 60 17 evolution evolution NN cord-018017-c8myq6bi 60 18 ? ? . cord-018017-c8myq6bi 61 1 Clearly clearly RB cord-018017-c8myq6bi 61 2 infections infection NNS cord-018017-c8myq6bi 61 3 pose pose VBP cord-018017-c8myq6bi 61 4 selection selection NN cord-018017-c8myq6bi 61 5 pressure pressure NN cord-018017-c8myq6bi 61 6 on on IN cord-018017-c8myq6bi 61 7 the the DT cord-018017-c8myq6bi 61 8 human human JJ cord-018017-c8myq6bi 61 9 populations population NNS cord-018017-c8myq6bi 61 10 . . . cord-018017-c8myq6bi 62 1 Origins origin NNS cord-018017-c8myq6bi 62 2 of of IN cord-018017-c8myq6bi 62 3 evolutionary evolutionary JJ cord-018017-c8myq6bi 62 4 thought thought NN cord-018017-c8myq6bi 62 5 did do VBD cord-018017-c8myq6bi 62 6 not not RB cord-018017-c8myq6bi 62 7 include include VB cord-018017-c8myq6bi 62 8 infection infection NN cord-018017-c8myq6bi 62 9 as as IN cord-018017-c8myq6bi 62 10 Darwin Darwin NNP cord-018017-c8myq6bi 62 11 established establish VBD cord-018017-c8myq6bi 62 12 key key JJ cord-018017-c8myq6bi 62 13 evolution evolution NN cord-018017-c8myq6bi 62 14 concepts concept NNS cord-018017-c8myq6bi 62 15 on on IN cord-018017-c8myq6bi 62 16 the the DT cord-018017-c8myq6bi 62 17 Galapagos Galapagos NNP cord-018017-c8myq6bi 62 18 Islands Islands NNPS cord-018017-c8myq6bi 62 19 . . . cord-018017-c8myq6bi 63 1 These these DT cord-018017-c8myq6bi 63 2 islands island NNS cord-018017-c8myq6bi 63 3 are be VBP cord-018017-c8myq6bi 63 4 isolated isolate VBN cord-018017-c8myq6bi 63 5 and and CC cord-018017-c8myq6bi 63 6 an an DT cord-018017-c8myq6bi 63 7 unlikely unlikely JJ cord-018017-c8myq6bi 63 8 place place NN cord-018017-c8myq6bi 63 9 for for IN cord-018017-c8myq6bi 63 10 the the DT cord-018017-c8myq6bi 63 11 spread spread NN cord-018017-c8myq6bi 63 12 of of IN cord-018017-c8myq6bi 63 13 infections infection NNS cord-018017-c8myq6bi 63 14 . . . cord-018017-c8myq6bi 64 1 The the DT cord-018017-c8myq6bi 64 2 concepts concept NNS cord-018017-c8myq6bi 64 3 speciation speciation NN cord-018017-c8myq6bi 64 4 point point NN cord-018017-c8myq6bi 64 5 to to IN cord-018017-c8myq6bi 64 6 geographical geographical JJ cord-018017-c8myq6bi 64 7 separation separation NN cord-018017-c8myq6bi 64 8 of of IN cord-018017-c8myq6bi 64 9 populations population NNS cord-018017-c8myq6bi 64 10 so so IN cord-018017-c8myq6bi 64 11 infections infection NNS cord-018017-c8myq6bi 64 12 would would MD cord-018017-c8myq6bi 64 13 most most RBS cord-018017-c8myq6bi 64 14 likely likely RB cord-018017-c8myq6bi 64 15 be be VB cord-018017-c8myq6bi 64 16 restricted restrict VBN cord-018017-c8myq6bi 64 17 to to IN cord-018017-c8myq6bi 64 18 isolated isolate VBN cord-018017-c8myq6bi 64 19 populations population NNS cord-018017-c8myq6bi 64 20 . . . cord-018017-c8myq6bi 65 1 In in IN cord-018017-c8myq6bi 65 2 many many JJ cord-018017-c8myq6bi 65 3 cases case NNS cord-018017-c8myq6bi 65 4 the the DT cord-018017-c8myq6bi 65 5 survival survival NN cord-018017-c8myq6bi 65 6 selection selection NN cord-018017-c8myq6bi 65 7 pressure pressure NN cord-018017-c8myq6bi 65 8 is be VBZ cord-018017-c8myq6bi 65 9 not not RB cord-018017-c8myq6bi 65 10 identified identify VBN cord-018017-c8myq6bi 65 11 or or CC cord-018017-c8myq6bi 65 12 ascribed ascribe VBN cord-018017-c8myq6bi 65 13 to to IN cord-018017-c8myq6bi 65 14 insufficient insufficient JJ cord-018017-c8myq6bi 65 15 sources source NNS cord-018017-c8myq6bi 65 16 of of IN cord-018017-c8myq6bi 65 17 food food NN cord-018017-c8myq6bi 65 18 . . . cord-018017-c8myq6bi 66 1 Unfortunately unfortunately RB cord-018017-c8myq6bi 66 2 , , , cord-018017-c8myq6bi 66 3 common common JJ cord-018017-c8myq6bi 66 4 single single RB cord-018017-c8myq6bi 66 5 - - HYPH cord-018017-c8myq6bi 66 6 stranded strand VBN cord-018017-c8myq6bi 66 7 RNA RNA NNP cord-018017-c8myq6bi 66 8 viruses virus NNS cord-018017-c8myq6bi 66 9 are be VBP cord-018017-c8myq6bi 66 10 so so RB cord-018017-c8myq6bi 66 11 unstable unstable JJ cord-018017-c8myq6bi 66 12 that that IN cord-018017-c8myq6bi 66 13 there there EX cord-018017-c8myq6bi 66 14 are be VBP cord-018017-c8myq6bi 66 15 limited limited JJ cord-018017-c8myq6bi 66 16 data datum NNS cord-018017-c8myq6bi 66 17 for for IN cord-018017-c8myq6bi 66 18 a a DT cord-018017-c8myq6bi 66 19 viral viral JJ cord-018017-c8myq6bi 66 20 fossil fossil NN cord-018017-c8myq6bi 66 21 record record NN cord-018017-c8myq6bi 66 22 . . . cord-018017-c8myq6bi 67 1 Pandemic pandemic NN cord-018017-c8myq6bi 67 2 infections infection NNS cord-018017-c8myq6bi 67 3 remain remain VBP cord-018017-c8myq6bi 67 4 a a DT cord-018017-c8myq6bi 67 5 threat threat NN cord-018017-c8myq6bi 67 6 to to IN cord-018017-c8myq6bi 67 7 human human JJ cord-018017-c8myq6bi 67 8 survival survival NN cord-018017-c8myq6bi 67 9 in in IN cord-018017-c8myq6bi 67 10 the the DT cord-018017-c8myq6bi 67 11 presence presence NN cord-018017-c8myq6bi 67 12 of of IN cord-018017-c8myq6bi 67 13 the the DT cord-018017-c8myq6bi 67 14 information information NN cord-018017-c8myq6bi 67 15 revolution revolution NN cord-018017-c8myq6bi 67 16 , , , cord-018017-c8myq6bi 67 17 daily daily JJ cord-018017-c8myq6bi 67 18 medical medical JJ cord-018017-c8myq6bi 67 19 breakthroughs breakthrough NNS cord-018017-c8myq6bi 67 20 , , , cord-018017-c8myq6bi 67 21 and and CC cord-018017-c8myq6bi 67 22 global global JJ cord-018017-c8myq6bi 67 23 travel travel NN cord-018017-c8myq6bi 67 24 . . . cord-018017-c8myq6bi 68 1 The the DT cord-018017-c8myq6bi 68 2 human human JJ cord-018017-c8myq6bi 68 3 retrovirus retrovirus NN cord-018017-c8myq6bi 68 4 HIV HIV NNP cord-018017-c8myq6bi 68 5 currently currently RB cord-018017-c8myq6bi 68 6 a a DT cord-018017-c8myq6bi 68 7 global global JJ cord-018017-c8myq6bi 68 8 infection infection NN cord-018017-c8myq6bi 68 9 that that WDT cord-018017-c8myq6bi 68 10 infects infect VBZ cord-018017-c8myq6bi 68 11 up up IN cord-018017-c8myq6bi 68 12 to to TO cord-018017-c8myq6bi 68 13 25 25 CD cord-018017-c8myq6bi 68 14 % % NN cord-018017-c8myq6bi 68 15 of of IN cord-018017-c8myq6bi 68 16 the the DT cord-018017-c8myq6bi 68 17 population population NN cord-018017-c8myq6bi 68 18 in in IN cord-018017-c8myq6bi 68 19 southern southern JJ cord-018017-c8myq6bi 68 20 and and CC cord-018017-c8myq6bi 68 21 eastern eastern JJ cord-018017-c8myq6bi 68 22 Africa Africa NNP cord-018017-c8myq6bi 68 23 with with IN cord-018017-c8myq6bi 68 24 a a DT cord-018017-c8myq6bi 68 25 projected project VBN cord-018017-c8myq6bi 68 26 death death NN cord-018017-c8myq6bi 68 27 toll toll NN cord-018017-c8myq6bi 68 28 of of IN cord-018017-c8myq6bi 68 29 up up IN cord-018017-c8myq6bi 68 30 to to TO cord-018017-c8myq6bi 68 31 100 100 CD cord-018017-c8myq6bi 68 32 million million CD cord-018017-c8myq6bi 68 33 by by IN cord-018017-c8myq6bi 68 34 2025 2025 CD cord-018017-c8myq6bi 68 35 . . . cord-018017-c8myq6bi 69 1 Measles measle NNS cord-018017-c8myq6bi 69 2 killed kill VBD cord-018017-c8myq6bi 69 3 200 200 CD cord-018017-c8myq6bi 69 4 million million CD cord-018017-c8myq6bi 69 5 people people NNS cord-018017-c8myq6bi 69 6 in in IN cord-018017-c8myq6bi 69 7 the the DT cord-018017-c8myq6bi 69 8 last last JJ cord-018017-c8myq6bi 69 9 150 150 CD cord-018017-c8myq6bi 69 10 years year NNS cord-018017-c8myq6bi 69 11 and and CC cord-018017-c8myq6bi 69 12 the the DT cord-018017-c8myq6bi 69 13 development development NN cord-018017-c8myq6bi 69 14 of of IN cord-018017-c8myq6bi 69 15 an an DT cord-018017-c8myq6bi 69 16 effective effective JJ cord-018017-c8myq6bi 69 17 vaccine vaccine NN cord-018017-c8myq6bi 69 18 in in IN cord-018017-c8myq6bi 69 19 1963 1963 CD cord-018017-c8myq6bi 69 20 reduced reduced JJ cord-018017-c8myq6bi 69 21 concerns concern NNS cord-018017-c8myq6bi 69 22 for for IN cord-018017-c8myq6bi 69 23 this this DT cord-018017-c8myq6bi 69 24 infection infection NN cord-018017-c8myq6bi 69 25 but but CC cord-018017-c8myq6bi 69 26 there there EX cord-018017-c8myq6bi 69 27 were be VBD cord-018017-c8myq6bi 69 28 777,000 777,000 CD cord-018017-c8myq6bi 69 29 deaths death NNS cord-018017-c8myq6bi 69 30 in in IN cord-018017-c8myq6bi 69 31 the the DT cord-018017-c8myq6bi 69 32 year year NN cord-018017-c8myq6bi 69 33 2000 2000 CD cord-018017-c8myq6bi 69 34 . . . cord-018017-c8myq6bi 70 1 Vaccination vaccination NN cord-018017-c8myq6bi 70 2 programs program NNS cord-018017-c8myq6bi 70 3 are be VBP cord-018017-c8myq6bi 70 4 frequently frequently RB cord-018017-c8myq6bi 70 5 disrupted disrupt VBN cord-018017-c8myq6bi 70 6 due due JJ cord-018017-c8myq6bi 70 7 to to IN cord-018017-c8myq6bi 70 8 complacence complacence NN cord-018017-c8myq6bi 70 9 resulting result VBG cord-018017-c8myq6bi 70 10 from from IN cord-018017-c8myq6bi 70 11 vaccine vaccine NN cord-018017-c8myq6bi 70 12 success success NN cord-018017-c8myq6bi 70 13 , , , cord-018017-c8myq6bi 70 14 conflicts conflict NNS cord-018017-c8myq6bi 70 15 that that WDT cord-018017-c8myq6bi 70 16 shift shift VBP cord-018017-c8myq6bi 70 17 healthcare healthcare NN cord-018017-c8myq6bi 70 18 focus focus NN cord-018017-c8myq6bi 70 19 , , , cord-018017-c8myq6bi 70 20 and and CC cord-018017-c8myq6bi 70 21 social social JJ cord-018017-c8myq6bi 70 22 crisis crisis NN cord-018017-c8myq6bi 70 23 such such JJ cord-018017-c8myq6bi 70 24 as as IN cord-018017-c8myq6bi 70 25 the the DT cord-018017-c8myq6bi 70 26 recent recent JJ cord-018017-c8myq6bi 70 27 Ebola Ebola NNP cord-018017-c8myq6bi 70 28 outbreak outbreak NN cord-018017-c8myq6bi 70 29 in in IN cord-018017-c8myq6bi 70 30 West West NNP cord-018017-c8myq6bi 70 31 Africa Africa NNP cord-018017-c8myq6bi 70 32 . . . cord-018017-c8myq6bi 71 1 Smallpox smallpox NN cord-018017-c8myq6bi 71 2 is be VBZ cord-018017-c8myq6bi 71 3 also also RB cord-018017-c8myq6bi 71 4 an an DT cord-018017-c8myq6bi 71 5 ancient ancient JJ cord-018017-c8myq6bi 71 6 infection infection NN cord-018017-c8myq6bi 71 7 causing cause VBG cord-018017-c8myq6bi 71 8 fever fever NN cord-018017-c8myq6bi 71 9 , , , cord-018017-c8myq6bi 71 10 skin skin NN cord-018017-c8myq6bi 71 11 lesions lesion NNS cord-018017-c8myq6bi 71 12 , , , cord-018017-c8myq6bi 71 13 and and CC cord-018017-c8myq6bi 71 14 at at IN cord-018017-c8myq6bi 71 15 times time NNS cord-018017-c8myq6bi 71 16 death death NN cord-018017-c8myq6bi 71 17 . . . cord-018017-c8myq6bi 72 1 King King NNP cord-018017-c8myq6bi 72 2 Ramses Ramses NNP cord-018017-c8myq6bi 72 3 V V NNP cord-018017-c8myq6bi 72 4 of of IN cord-018017-c8myq6bi 72 5 Egypt Egypt NNP cord-018017-c8myq6bi 72 6 is be VBZ cord-018017-c8myq6bi 72 7 thought think VBN cord-018017-c8myq6bi 72 8 to to TO cord-018017-c8myq6bi 72 9 have have VB cord-018017-c8myq6bi 72 10 died die VBN cord-018017-c8myq6bi 72 11 from from IN cord-018017-c8myq6bi 72 12 smallpox smallpox NN cord-018017-c8myq6bi 72 13 around around IN cord-018017-c8myq6bi 72 14 1200 1200 CD cord-018017-c8myq6bi 72 15 BCE BCE NNP cord-018017-c8myq6bi 72 16 . . . cord-018017-c8myq6bi 73 1 Introduced introduce VBN cord-018017-c8myq6bi 73 2 into into IN cord-018017-c8myq6bi 73 3 Mexico Mexico NNP cord-018017-c8myq6bi 73 4 in in IN cord-018017-c8myq6bi 73 5 1520 1520 CD cord-018017-c8myq6bi 73 6 , , , cord-018017-c8myq6bi 73 7 smallpox smallpox NN cord-018017-c8myq6bi 73 8 killed kill VBD cord-018017-c8myq6bi 73 9 3.5 3.5 CD cord-018017-c8myq6bi 73 10 million million CD cord-018017-c8myq6bi 73 11 Aztec aztec JJ cord-018017-c8myq6bi 73 12 Indians Indians NNPS cord-018017-c8myq6bi 73 13 or or CC cord-018017-c8myq6bi 73 14 about about IN cord-018017-c8myq6bi 73 15 half half NN cord-018017-c8myq6bi 73 16 of of IN cord-018017-c8myq6bi 73 17 the the DT cord-018017-c8myq6bi 73 18 population population NN cord-018017-c8myq6bi 73 19 in in IN cord-018017-c8myq6bi 73 20 a a DT cord-018017-c8myq6bi 73 21 period period NN cord-018017-c8myq6bi 73 22 of of IN cord-018017-c8myq6bi 73 23 2 2 CD cord-018017-c8myq6bi 73 24 years year NNS cord-018017-c8myq6bi 73 25 and and CC cord-018017-c8myq6bi 73 26 then then RB cord-018017-c8myq6bi 73 27 proceeded proceed VBD cord-018017-c8myq6bi 73 28 to to TO cord-018017-c8myq6bi 73 29 decimate decimate VB cord-018017-c8myq6bi 73 30 the the DT cord-018017-c8myq6bi 73 31 population population NN cord-018017-c8myq6bi 73 32 of of IN cord-018017-c8myq6bi 73 33 South South NNP cord-018017-c8myq6bi 73 34 America America NNP cord-018017-c8myq6bi 73 35 . . . cord-018017-c8myq6bi 74 1 Variola variola NN cord-018017-c8myq6bi 74 2 is be VBZ cord-018017-c8myq6bi 74 3 a a DT cord-018017-c8myq6bi 74 4 highly highly RB cord-018017-c8myq6bi 74 5 infectious infectious JJ cord-018017-c8myq6bi 74 6 virus virus NN cord-018017-c8myq6bi 74 7 killing kill VBG cord-018017-c8myq6bi 74 8 300 300 CD cord-018017-c8myq6bi 74 9 - - SYM cord-018017-c8myq6bi 74 10 500 500 CD cord-018017-c8myq6bi 74 11 million million CD cord-018017-c8myq6bi 74 12 people people NNS cord-018017-c8myq6bi 74 13 during during IN cord-018017-c8myq6bi 74 14 the the DT cord-018017-c8myq6bi 74 15 20th 20th JJ cord-018017-c8myq6bi 74 16 century century NN cord-018017-c8myq6bi 74 17 inspiring inspire VBG cord-018017-c8myq6bi 74 18 the the DT cord-018017-c8myq6bi 74 19 eradication eradication NN cord-018017-c8myq6bi 74 20 campaign campaign NN cord-018017-c8myq6bi 74 21 in in IN cord-018017-c8myq6bi 74 22 1967 1967 CD cord-018017-c8myq6bi 74 23 . . . cord-018017-c8myq6bi 75 1 Variola Variola NNP cord-018017-c8myq6bi 75 2 was be VBD cord-018017-c8myq6bi 75 3 eradicated eradicate VBN cord-018017-c8myq6bi 75 4 by by IN cord-018017-c8myq6bi 75 5 December December NNP cord-018017-c8myq6bi 75 6 of of IN cord-018017-c8myq6bi 75 7 1979 1979 CD cord-018017-c8myq6bi 75 8 ( ( -LRB- cord-018017-c8myq6bi 75 9 De De NNP cord-018017-c8myq6bi 75 10 Cock Cock NNP cord-018017-c8myq6bi 75 11 2001 2001 CD cord-018017-c8myq6bi 75 12 , , , cord-018017-c8myq6bi 75 13 a a DT cord-018017-c8myq6bi 75 14 rare rare JJ cord-018017-c8myq6bi 75 15 triumph triumph NN cord-018017-c8myq6bi 75 16 of of IN cord-018017-c8myq6bi 75 17 public public JJ cord-018017-c8myq6bi 75 18 health health NN cord-018017-c8myq6bi 75 19 . . . cord-018017-c8myq6bi 76 1 The the DT cord-018017-c8myq6bi 76 2 WHO who WP cord-018017-c8myq6bi 76 3 deserves deserve VBZ cord-018017-c8myq6bi 76 4 acknowledgment acknowledgment NN cord-018017-c8myq6bi 76 5 for for IN cord-018017-c8myq6bi 76 6 this this DT cord-018017-c8myq6bi 76 7 unprecedented unprecedented JJ cord-018017-c8myq6bi 76 8 accomplishment accomplishment NN cord-018017-c8myq6bi 76 9 and and CC cord-018017-c8myq6bi 76 10 proof proof NN cord-018017-c8myq6bi 76 11 of of IN cord-018017-c8myq6bi 76 12 concept concept NN cord-018017-c8myq6bi 76 13 that that IN cord-018017-c8myq6bi 76 14 human human JJ cord-018017-c8myq6bi 76 15 suffering suffering NN cord-018017-c8myq6bi 76 16 is be VBZ cord-018017-c8myq6bi 76 17 not not RB cord-018017-c8myq6bi 76 18 inevita inevita NN cord-018017-c8myq6bi 76 19 - - HYPH cord-018017-c8myq6bi 76 20 ble ble JJ cord-018017-c8myq6bi 76 21 . . . cord-018017-c8myq6bi 77 1 However however RB cord-018017-c8myq6bi 77 2 , , , cord-018017-c8myq6bi 77 3 variola variola NN cord-018017-c8myq6bi 77 4 is be VBZ cord-018017-c8myq6bi 77 5 a a DT cord-018017-c8myq6bi 77 6 DNA dna NN cord-018017-c8myq6bi 77 7 virus virus NN cord-018017-c8myq6bi 77 8 with with IN cord-018017-c8myq6bi 77 9 limited limited JJ cord-018017-c8myq6bi 77 10 rate rate NN cord-018017-c8myq6bi 77 11 of of IN cord-018017-c8myq6bi 77 12 mutation mutation NN cord-018017-c8myq6bi 77 13 and and CC cord-018017-c8myq6bi 77 14 a a DT cord-018017-c8myq6bi 77 15 narrow narrow JJ cord-018017-c8myq6bi 77 16 host host NN cord-018017-c8myq6bi 77 17 range range NN cord-018017-c8myq6bi 77 18 so so IN cord-018017-c8myq6bi 77 19 that that IN cord-018017-c8myq6bi 77 20 animal animal NN cord-018017-c8myq6bi 77 21 reservoirs reservoir NNS cord-018017-c8myq6bi 77 22 do do VBP cord-018017-c8myq6bi 77 23 not not RB cord-018017-c8myq6bi 77 24 exist exist VB cord-018017-c8myq6bi 77 25 . . . cord-018017-c8myq6bi 78 1 The the DT cord-018017-c8myq6bi 78 2 eradication eradication NN cord-018017-c8myq6bi 78 3 of of IN cord-018017-c8myq6bi 78 4 other other JJ cord-018017-c8myq6bi 78 5 viral viral JJ cord-018017-c8myq6bi 78 6 infections infection NNS cord-018017-c8myq6bi 78 7 will will MD cord-018017-c8myq6bi 78 8 be be VB cord-018017-c8myq6bi 78 9 more more RBR cord-018017-c8myq6bi 78 10 challenging challenging JJ cord-018017-c8myq6bi 78 11 . . . cord-018017-c8myq6bi 79 1 The the DT cord-018017-c8myq6bi 79 2 world world NN cord-018017-c8myq6bi 79 3 continues continue VBZ cord-018017-c8myq6bi 79 4 to to TO cord-018017-c8myq6bi 79 5 confront confront VB cord-018017-c8myq6bi 79 6 a a DT cord-018017-c8myq6bi 79 7 broad broad JJ cord-018017-c8myq6bi 79 8 array array NN cord-018017-c8myq6bi 79 9 of of IN cord-018017-c8myq6bi 79 10 microbial microbial JJ cord-018017-c8myq6bi 79 11 threats threat NNS cord-018017-c8myq6bi 79 12 . . . cord-018017-c8myq6bi 80 1 Progress progress NN cord-018017-c8myq6bi 80 2 and and CC cord-018017-c8myq6bi 80 3 preparedness preparedness NN cord-018017-c8myq6bi 80 4 make make VBP cord-018017-c8myq6bi 80 5 our -PRON- PRP$ cord-018017-c8myq6bi 80 6 engagement engagement NN cord-018017-c8myq6bi 80 7 a a DT cord-018017-c8myq6bi 80 8 likely likely JJ cord-018017-c8myq6bi 80 9 success success NN cord-018017-c8myq6bi 80 10 for for IN cord-018017-c8myq6bi 80 11 those those DT cord-018017-c8myq6bi 80 12 microbes microbe NNS cord-018017-c8myq6bi 80 13 that that WDT cord-018017-c8myq6bi 80 14 resurface resurface VBP cord-018017-c8myq6bi 80 15 and and CC cord-018017-c8myq6bi 80 16 infections infection NNS cord-018017-c8myq6bi 80 17 for for IN cord-018017-c8myq6bi 80 18 which which WDT cord-018017-c8myq6bi 80 19 we -PRON- PRP cord-018017-c8myq6bi 80 20 have have VBP cord-018017-c8myq6bi 80 21 experience experience NN cord-018017-c8myq6bi 80 22 . . . cord-018017-c8myq6bi 81 1 Medical medical JJ cord-018017-c8myq6bi 81 2 and and CC cord-018017-c8myq6bi 81 3 epidemiological epidemiological JJ cord-018017-c8myq6bi 81 4 uncertainties uncertainty NNS cord-018017-c8myq6bi 81 5 surround surround VBP cord-018017-c8myq6bi 81 6 emerging emerge VBG cord-018017-c8myq6bi 81 7 infectious infectious JJ cord-018017-c8myq6bi 81 8 disease disease NN cord-018017-c8myq6bi 81 9 , , , cord-018017-c8myq6bi 81 10 those those DT cord-018017-c8myq6bi 81 11 that that WDT cord-018017-c8myq6bi 81 12 challenge challenge VBP cord-018017-c8myq6bi 81 13 us -PRON- PRP cord-018017-c8myq6bi 81 14 with with IN cord-018017-c8myq6bi 81 15 their -PRON- PRP$ cord-018017-c8myq6bi 81 16 novelty novelty NN cord-018017-c8myq6bi 81 17 . . . cord-018017-c8myq6bi 82 1 Pandemics pandemic NNS cord-018017-c8myq6bi 82 2 dominate dominate VBP cord-018017-c8myq6bi 82 3 the the DT cord-018017-c8myq6bi 82 4 infectious infectious JJ cord-018017-c8myq6bi 82 5 disease disease NN cord-018017-c8myq6bi 82 6 " " '' cord-018017-c8myq6bi 82 7 fear fear NN cord-018017-c8myq6bi 82 8 factor factor NN cord-018017-c8myq6bi 82 9 " " '' cord-018017-c8myq6bi 82 10 but but CC cord-018017-c8myq6bi 82 11 each each DT cord-018017-c8myq6bi 82 12 pandemic pandemic NN cord-018017-c8myq6bi 82 13 began begin VBD cord-018017-c8myq6bi 82 14 as as IN cord-018017-c8myq6bi 82 15 a a DT cord-018017-c8myq6bi 82 16 much much RB cord-018017-c8myq6bi 82 17 more more RBR cord-018017-c8myq6bi 82 18 frequent frequent JJ cord-018017-c8myq6bi 82 19 occurrence occurrence NN cord-018017-c8myq6bi 82 20 , , , cord-018017-c8myq6bi 82 21 an an DT cord-018017-c8myq6bi 82 22 epidemic epidemic NN cord-018017-c8myq6bi 82 23 . . . cord-018017-c8myq6bi 83 1 Most Most JJS cord-018017-c8myq6bi 83 2 but but CC cord-018017-c8myq6bi 83 3 not not RB cord-018017-c8myq6bi 83 4 all all DT cord-018017-c8myq6bi 83 5 epidemics epidemic NNS cord-018017-c8myq6bi 83 6 come come VBP cord-018017-c8myq6bi 83 7 from from IN cord-018017-c8myq6bi 83 8 emerging emerge VBG cord-018017-c8myq6bi 83 9 infectious infectious JJ cord-018017-c8myq6bi 83 10 agents agent NNS cord-018017-c8myq6bi 83 11 , , , cord-018017-c8myq6bi 83 12 the the DT cord-018017-c8myq6bi 83 13 most most RBS cord-018017-c8myq6bi 83 14 significant significant JJ cord-018017-c8myq6bi 83 15 problem problem NN cord-018017-c8myq6bi 83 16 facing face VBG cord-018017-c8myq6bi 83 17 life life NN cord-018017-c8myq6bi 83 18 on on IN cord-018017-c8myq6bi 83 19 earth earth NN cord-018017-c8myq6bi 83 20 today today NN cord-018017-c8myq6bi 83 21 . . . cord-018017-c8myq6bi 84 1 The the DT cord-018017-c8myq6bi 84 2 concept concept NN cord-018017-c8myq6bi 84 3 of of IN cord-018017-c8myq6bi 84 4 emerging emerge VBG cord-018017-c8myq6bi 84 5 is be VBZ cord-018017-c8myq6bi 84 6 a a DT cord-018017-c8myq6bi 84 7 human human JJ cord-018017-c8myq6bi 84 8 centric centric NN cord-018017-c8myq6bi 84 9 term term NN cord-018017-c8myq6bi 84 10 as as IN cord-018017-c8myq6bi 84 11 most most JJS cord-018017-c8myq6bi 84 12 of of IN cord-018017-c8myq6bi 84 13 these these DT cord-018017-c8myq6bi 84 14 infections infection NNS cord-018017-c8myq6bi 84 15 are be VBP cord-018017-c8myq6bi 84 16 endemic endemic JJ cord-018017-c8myq6bi 84 17 in in IN cord-018017-c8myq6bi 84 18 an an DT cord-018017-c8myq6bi 84 19 animal animal NN cord-018017-c8myq6bi 84 20 host host NN cord-018017-c8myq6bi 84 21 that that WDT cord-018017-c8myq6bi 84 22 serves serve VBZ cord-018017-c8myq6bi 84 23 as as IN cord-018017-c8myq6bi 84 24 a a DT cord-018017-c8myq6bi 84 25 viral viral JJ cord-018017-c8myq6bi 84 26 reservoir reservoir NN cord-018017-c8myq6bi 84 27 . . . cord-018017-c8myq6bi 85 1 A a DT cord-018017-c8myq6bi 85 2 2005 2005 CD cord-018017-c8myq6bi 85 3 report report NN cord-018017-c8myq6bi 85 4 from from IN cord-018017-c8myq6bi 85 5 the the DT cord-018017-c8myq6bi 85 6 University University NNP cord-018017-c8myq6bi 85 7 of of IN cord-018017-c8myq6bi 85 8 Edinburgh Edinburgh NNP cord-018017-c8myq6bi 85 9 identified identify VBD cord-018017-c8myq6bi 85 10 1407 1407 CD cord-018017-c8myq6bi 85 11 human human JJ cord-018017-c8myq6bi 85 12 pathogens pathogen NNS cord-018017-c8myq6bi 85 13 and and CC cord-018017-c8myq6bi 85 14 177 177 CD cord-018017-c8myq6bi 85 15 are be VBP cord-018017-c8myq6bi 85 16 emerging emerge VBG cord-018017-c8myq6bi 85 17 or or CC cord-018017-c8myq6bi 85 18 re re VB cord-018017-c8myq6bi 85 19 - - NN cord-018017-c8myq6bi 85 20 emerging emerging NN cord-018017-c8myq6bi 85 21 of of IN cord-018017-c8myq6bi 85 22 which which WDT cord-018017-c8myq6bi 85 23 75 75 CD cord-018017-c8myq6bi 85 24 % % NN cord-018017-c8myq6bi 85 25 are be VBP cord-018017-c8myq6bi 85 26 zoonotic zoonotic JJ cord-018017-c8myq6bi 85 27 , , , cord-018017-c8myq6bi 85 28 that that RB cord-018017-c8myq6bi 85 29 is be VBZ cord-018017-c8myq6bi 85 30 jump jump VB cord-018017-c8myq6bi 85 31 from from IN cord-018017-c8myq6bi 85 32 an an DT cord-018017-c8myq6bi 85 33 animal animal NN cord-018017-c8myq6bi 85 34 host host NN cord-018017-c8myq6bi 85 35 to to IN cord-018017-c8myq6bi 85 36 human human NN cord-018017-c8myq6bi 85 37 . . . cord-018017-c8myq6bi 86 1 Numerous numerous JJ cord-018017-c8myq6bi 86 2 emerging emerge VBG cord-018017-c8myq6bi 86 3 infections infection NNS cord-018017-c8myq6bi 86 4 caused cause VBN cord-018017-c8myq6bi 86 5 by by IN cord-018017-c8myq6bi 86 6 viral viral JJ cord-018017-c8myq6bi 86 7 agents agent NNS cord-018017-c8myq6bi 86 8 have have VBP cord-018017-c8myq6bi 86 9 imposed impose VBN cord-018017-c8myq6bi 86 10 high high JJ cord-018017-c8myq6bi 86 11 impact impact NN cord-018017-c8myq6bi 86 12 on on IN cord-018017-c8myq6bi 86 13 human human JJ cord-018017-c8myq6bi 86 14 survival survival NN cord-018017-c8myq6bi 86 15 ( ( -LRB- cord-018017-c8myq6bi 86 16 Table table NN cord-018017-c8myq6bi 86 17 3 3 CD cord-018017-c8myq6bi 86 18 .3 .3 NFP cord-018017-c8myq6bi 86 19 ) ) -RRB- cord-018017-c8myq6bi 86 20 . . . cord-018017-c8myq6bi 87 1 All all PDT cord-018017-c8myq6bi 87 2 the the DT cord-018017-c8myq6bi 87 3 viral viral JJ cord-018017-c8myq6bi 87 4 agents agent NNS cord-018017-c8myq6bi 87 5 in in IN cord-018017-c8myq6bi 87 6 Table Table NNP cord-018017-c8myq6bi 87 7 3 3 CD cord-018017-c8myq6bi 87 8 .3 .3 NFP cord-018017-c8myq6bi 87 9 have have VBP cord-018017-c8myq6bi 87 10 genomes genome NNS cord-018017-c8myq6bi 87 11 based base VBN cord-018017-c8myq6bi 87 12 on on IN cord-018017-c8myq6bi 87 13 single single JJ cord-018017-c8myq6bi 87 14 - - HYPH cord-018017-c8myq6bi 87 15 strands strand NNS cord-018017-c8myq6bi 87 16 of of IN cord-018017-c8myq6bi 87 17 RNA RNA NNP cord-018017-c8myq6bi 87 18 except except IN cord-018017-c8myq6bi 87 19 HBV HBV NNP cord-018017-c8myq6bi 87 20 which which WDT cord-018017-c8myq6bi 87 21 should should MD cord-018017-c8myq6bi 87 22 focus focus VB cord-018017-c8myq6bi 87 23 scientific scientific JJ cord-018017-c8myq6bi 87 24 attention attention NN cord-018017-c8myq6bi 87 25 on on IN cord-018017-c8myq6bi 87 26 RNA RNA NNP cord-018017-c8myq6bi 87 27 . . . cord-018017-c8myq6bi 88 1 There there EX cord-018017-c8myq6bi 88 2 are be VBP cord-018017-c8myq6bi 88 3 numerous numerous JJ cord-018017-c8myq6bi 88 4 questions question NNS cord-018017-c8myq6bi 88 5 that that WDT cord-018017-c8myq6bi 88 6 strike strike VBP cord-018017-c8myq6bi 88 7 investigators investigator NNS cord-018017-c8myq6bi 88 8 as as IN cord-018017-c8myq6bi 88 9 they -PRON- PRP cord-018017-c8myq6bi 88 10 ponder ponder VBP cord-018017-c8myq6bi 88 11 a a DT cord-018017-c8myq6bi 88 12 collection collection NN cord-018017-c8myq6bi 88 13 of of IN cord-018017-c8myq6bi 88 14 viral viral JJ cord-018017-c8myq6bi 88 15 agents agent NNS cord-018017-c8myq6bi 88 16 like like IN cord-018017-c8myq6bi 88 17 those those DT cord-018017-c8myq6bi 88 18 in in IN cord-018017-c8myq6bi 88 19 Table Table NNP cord-018017-c8myq6bi 88 20 3 3 CD cord-018017-c8myq6bi 88 21 .3 .3 NFP cord-018017-c8myq6bi 88 22 . . . cord-018017-c8myq6bi 89 1 The the DT cord-018017-c8myq6bi 89 2 viral viral JJ cord-018017-c8myq6bi 89 3 polymerase polymerase NN cord-018017-c8myq6bi 89 4 errors error NNS cord-018017-c8myq6bi 89 5 in in IN cord-018017-c8myq6bi 89 6 replicating replicate VBG cord-018017-c8myq6bi 89 7 single single RB cord-018017-c8myq6bi 89 8 - - HYPH cord-018017-c8myq6bi 89 9 stranded strand VBN cord-018017-c8myq6bi 89 10 RNA RNA NNP cord-018017-c8myq6bi 89 11 genomes genome NNS cord-018017-c8myq6bi 89 12 are be VBP cord-018017-c8myq6bi 89 13 not not RB cord-018017-c8myq6bi 89 14 corrected correct VBN cord-018017-c8myq6bi 89 15 so so IN cord-018017-c8myq6bi 89 16 the the DT cord-018017-c8myq6bi 89 17 species specie NNS cord-018017-c8myq6bi 89 18 are be VBP cord-018017-c8myq6bi 89 19 constantly constantly RB cord-018017-c8myq6bi 89 20 changing change VBG cord-018017-c8myq6bi 89 21 . . . cord-018017-c8myq6bi 90 1 The the DT cord-018017-c8myq6bi 90 2 apparent apparent JJ cord-018017-c8myq6bi 90 3 success success NN cord-018017-c8myq6bi 90 4 of of IN cord-018017-c8myq6bi 90 5 these these DT cord-018017-c8myq6bi 90 6 viruses virus NNS cord-018017-c8myq6bi 90 7 is be VBZ cord-018017-c8myq6bi 90 8 that that IN cord-018017-c8myq6bi 90 9 as as IN cord-018017-c8myq6bi 90 10 they -PRON- PRP cord-018017-c8myq6bi 90 11 move move VBP cord-018017-c8myq6bi 90 12 from from IN cord-018017-c8myq6bi 90 13 reservoir reservoir NN cord-018017-c8myq6bi 90 14 hosts host NNS cord-018017-c8myq6bi 90 15 to to IN cord-018017-c8myq6bi 90 16 humans human NNS cord-018017-c8myq6bi 90 17 and and CC cord-018017-c8myq6bi 90 18 as as IN cord-018017-c8myq6bi 90 19 humans human NNS cord-018017-c8myq6bi 90 20 become become VBP cord-018017-c8myq6bi 90 21 immune immune JJ cord-018017-c8myq6bi 90 22 to to IN cord-018017-c8myq6bi 90 23 the the DT cord-018017-c8myq6bi 90 24 initial initial JJ cord-018017-c8myq6bi 90 25 infection infection NN cord-018017-c8myq6bi 90 26 , , , cord-018017-c8myq6bi 90 27 the the DT cord-018017-c8myq6bi 90 28 population population NN cord-018017-c8myq6bi 90 29 of of IN cord-018017-c8myq6bi 90 30 diverse diverse JJ cord-018017-c8myq6bi 90 31 genomes genome NNS cord-018017-c8myq6bi 90 32 offers offer VBZ cord-018017-c8myq6bi 90 33 multiple multiple JJ cord-018017-c8myq6bi 90 34 chances chance NNS cord-018017-c8myq6bi 90 35 to to TO cord-018017-c8myq6bi 90 36 adapt adapt VB cord-018017-c8myq6bi 90 37 by by IN cord-018017-c8myq6bi 90 38 finding find VBG cord-018017-c8myq6bi 90 39 a a DT cord-018017-c8myq6bi 90 40 " " `` cord-018017-c8myq6bi 90 41 fit fit JJ cord-018017-c8myq6bi 90 42 " " '' cord-018017-c8myq6bi 90 43 genome genome NN cord-018017-c8myq6bi 90 44 version version NN cord-018017-c8myq6bi 90 45 which which WDT cord-018017-c8myq6bi 90 46 can can MD cord-018017-c8myq6bi 90 47 propagate propagate VB cord-018017-c8myq6bi 90 48 until until IN cord-018017-c8myq6bi 90 49 the the DT cord-018017-c8myq6bi 90 50 next next JJ cord-018017-c8myq6bi 90 51 transition transition NN cord-018017-c8myq6bi 90 52 requiring require VBG cord-018017-c8myq6bi 90 53 adaption adaption NN cord-018017-c8myq6bi 90 54 . . . cord-018017-c8myq6bi 91 1 Acquired Acquired NNP cord-018017-c8myq6bi 91 2 Immunodeficiency Immunodeficiency NNP cord-018017-c8myq6bi 91 3 Syndrome Syndrome NNP cord-018017-c8myq6bi 91 4 ( ( -LRB- cord-018017-c8myq6bi 91 5 AIDS AIDS NNP cord-018017-c8myq6bi 91 6 ) ) -RRB- cord-018017-c8myq6bi 91 7 is be VBZ cord-018017-c8myq6bi 91 8 caused cause VBN cord-018017-c8myq6bi 91 9 by by IN cord-018017-c8myq6bi 91 10 human human JJ cord-018017-c8myq6bi 91 11 immunodeficiency immunodeficiency NN cord-018017-c8myq6bi 91 12 virus virus NN cord-018017-c8myq6bi 91 13 1 1 CD cord-018017-c8myq6bi 91 14 ( ( -LRB- cord-018017-c8myq6bi 91 15 HIV-1 HIV-1 NNP cord-018017-c8myq6bi 91 16 ) ) -RRB- cord-018017-c8myq6bi 91 17 , , , cord-018017-c8myq6bi 91 18 a a DT cord-018017-c8myq6bi 91 19 retrovirus retrovirus NN cord-018017-c8myq6bi 91 20 . . . cord-018017-c8myq6bi 92 1 These these DT cord-018017-c8myq6bi 92 2 viruses virus NNS cord-018017-c8myq6bi 92 3 have have VBP cord-018017-c8myq6bi 92 4 a a DT cord-018017-c8myq6bi 92 5 single single RB cord-018017-c8myq6bi 92 6 - - HYPH cord-018017-c8myq6bi 92 7 stranded strand VBN cord-018017-c8myq6bi 92 8 RNA RNA NNP cord-018017-c8myq6bi 92 9 genome genome NN cord-018017-c8myq6bi 92 10 that that WDT cord-018017-c8myq6bi 92 11 is be VBZ cord-018017-c8myq6bi 92 12 converted convert VBN cord-018017-c8myq6bi 92 13 into into IN cord-018017-c8myq6bi 92 14 DNA DNA NNP cord-018017-c8myq6bi 92 15 , , , cord-018017-c8myq6bi 92 16 a a DT cord-018017-c8myq6bi 92 17 paradigm paradigm NN cord-018017-c8myq6bi 92 18 shift shift NN cord-018017-c8myq6bi 92 19 in in IN cord-018017-c8myq6bi 92 20 the the DT cord-018017-c8myq6bi 92 21 flow flow NN cord-018017-c8myq6bi 92 22 of of IN cord-018017-c8myq6bi 92 23 genetic genetic JJ cord-018017-c8myq6bi 92 24 information information NN cord-018017-c8myq6bi 92 25 from from IN cord-018017-c8myq6bi 92 26 DNA DNA NNP cord-018017-c8myq6bi 92 27 to to IN cord-018017-c8myq6bi 92 28 RNA RNA NNP cord-018017-c8myq6bi 92 29 . . . cord-018017-c8myq6bi 93 1 The the DT cord-018017-c8myq6bi 93 2 36,000,000 36,000,000 CD cord-018017-c8myq6bi 93 3 human human JJ cord-018017-c8myq6bi 93 4 deaths death NNS cord-018017-c8myq6bi 93 5 caused cause VBN cord-018017-c8myq6bi 93 6 by by IN cord-018017-c8myq6bi 93 7 HIV-1 HIV-1 NNP cord-018017-c8myq6bi 93 8 ( ( -LRB- cord-018017-c8myq6bi 93 9 Table Table NNP cord-018017-c8myq6bi 93 10 3.3 3.3 CD cord-018017-c8myq6bi 93 11 ) ) -RRB- cord-018017-c8myq6bi 93 12 is be VBZ cord-018017-c8myq6bi 93 13 accompanied accompany VBN cord-018017-c8myq6bi 93 14 by by IN cord-018017-c8myq6bi 93 15 a a DT cord-018017-c8myq6bi 93 16 spectrum spectrum NN cord-018017-c8myq6bi 93 17 of of IN cord-018017-c8myq6bi 93 18 clinical clinical JJ cord-018017-c8myq6bi 93 19 signs sign NNS cord-018017-c8myq6bi 93 20 ; ; : cord-018017-c8myq6bi 93 21 eg eg NNS cord-018017-c8myq6bi 93 22 . . . cord-018017-c8myq6bi 93 23 fever fever NN cord-018017-c8myq6bi 93 24 , , , cord-018017-c8myq6bi 93 25 diarrhea diarrhea NN cord-018017-c8myq6bi 93 26 , , , cord-018017-c8myq6bi 93 27 peripheral peripheral JJ cord-018017-c8myq6bi 93 28 neuropathy neuropathy NN cord-018017-c8myq6bi 93 29 , , , cord-018017-c8myq6bi 93 30 pelvic pelvic JJ cord-018017-c8myq6bi 93 31 inflammatory inflammatory JJ cord-018017-c8myq6bi 93 32 disease disease NN cord-018017-c8myq6bi 93 33 , , , cord-018017-c8myq6bi 93 34 cervical cervical JJ cord-018017-c8myq6bi 93 35 cancer cancer NN cord-018017-c8myq6bi 93 36 , , , cord-018017-c8myq6bi 93 37 cytomegalovirus cytomegalovirus JJ cord-018017-c8myq6bi 93 38 retinitis retinitis NN cord-018017-c8myq6bi 93 39 , , , cord-018017-c8myq6bi 93 40 Kaposi Kaposi NNP cord-018017-c8myq6bi 93 41 's 's POS cord-018017-c8myq6bi 93 42 sarcoma sarcoma NN cord-018017-c8myq6bi 93 43 , , , cord-018017-c8myq6bi 93 44 lymphoma lymphoma NN cord-018017-c8myq6bi 93 45 , , , cord-018017-c8myq6bi 94 1 Mycobacterium mycobacterium NN cord-018017-c8myq6bi 94 2 avium avium NN cord-018017-c8myq6bi 94 3 infection infection NN cord-018017-c8myq6bi 94 4 , , , cord-018017-c8myq6bi 94 5 recurrent recurrent JJ cord-018017-c8myq6bi 94 6 pneumonia pneumonia NN cord-018017-c8myq6bi 94 7 , , , cord-018017-c8myq6bi 94 8 and and CC cord-018017-c8myq6bi 94 9 wasting waste VBG cord-018017-c8myq6bi 94 10 syndrome syndrome NN cord-018017-c8myq6bi 94 11 . . . cord-018017-c8myq6bi 95 1 HIV-1 HIV-1 NNP cord-018017-c8myq6bi 95 2 genome genome NN cord-018017-c8myq6bi 95 3 diversity diversity NN cord-018017-c8myq6bi 95 4 includes include VBZ cord-018017-c8myq6bi 95 5 base base NN cord-018017-c8myq6bi 95 6 substitution substitution NN cord-018017-c8myq6bi 95 7 , , , cord-018017-c8myq6bi 95 8 insertion insertion NN cord-018017-c8myq6bi 95 9 , , , cord-018017-c8myq6bi 95 10 deletion deletion NN cord-018017-c8myq6bi 95 11 , , , cord-018017-c8myq6bi 95 12 recombination recombination NN cord-018017-c8myq6bi 95 13 , , , cord-018017-c8myq6bi 95 14 and and CC cord-018017-c8myq6bi 95 15 gain gain VB cord-018017-c8myq6bi 95 16 or or CC cord-018017-c8myq6bi 95 17 loss loss NN cord-018017-c8myq6bi 95 18 of of IN cord-018017-c8myq6bi 95 19 glycosylation glycosylation NN cord-018017-c8myq6bi 95 20 sites site NNS cord-018017-c8myq6bi 95 21 which which WDT cord-018017-c8myq6bi 95 22 all all DT cord-018017-c8myq6bi 95 23 arises arise VBZ cord-018017-c8myq6bi 95 24 from from IN cord-018017-c8myq6bi 95 25 the the DT cord-018017-c8myq6bi 95 26 limited limited JJ cord-018017-c8myq6bi 95 27 fidelity fidelity NN cord-018017-c8myq6bi 95 28 of of IN cord-018017-c8myq6bi 95 29 the the DT cord-018017-c8myq6bi 95 30 viral viral JJ cord-018017-c8myq6bi 95 31 reverse reverse NN cord-018017-c8myq6bi 95 32 transcriptase transcriptase NN cord-018017-c8myq6bi 95 33 . . . cord-018017-c8myq6bi 96 1 These these DT cord-018017-c8myq6bi 96 2 mutations mutation NNS cord-018017-c8myq6bi 96 3 are be VBP cord-018017-c8myq6bi 96 4 found find VBN cord-018017-c8myq6bi 96 5 in in IN cord-018017-c8myq6bi 96 6 clusters cluster NNS cord-018017-c8myq6bi 96 7 or or CC cord-018017-c8myq6bi 96 8 hypervariable hypervariable JJ cord-018017-c8myq6bi 96 9 regions region NNS cord-018017-c8myq6bi 96 10 indicating indicate VBG cord-018017-c8myq6bi 96 11 the the DT cord-018017-c8myq6bi 96 12 fit fit JJ cord-018017-c8myq6bi 96 13 virus virus NN cord-018017-c8myq6bi 96 14 is be VBZ cord-018017-c8myq6bi 96 15 selected select VBN cord-018017-c8myq6bi 96 16 for for IN cord-018017-c8myq6bi 96 17 from from IN cord-018017-c8myq6bi 96 18 vast vast JJ cord-018017-c8myq6bi 96 19 numbers number NNS cord-018017-c8myq6bi 96 20 of of IN cord-018017-c8myq6bi 96 21 less less RBR cord-018017-c8myq6bi 96 22 - - HYPH cord-018017-c8myq6bi 96 23 fit fit JJ cord-018017-c8myq6bi 96 24 genome genome NN cord-018017-c8myq6bi 96 25 sequences sequence NNS cord-018017-c8myq6bi 96 26 . . . cord-018017-c8myq6bi 97 1 HIV-1 HIV-1 NNP cord-018017-c8myq6bi 97 2 emphasizes emphasize VBZ cord-018017-c8myq6bi 97 3 key key JJ cord-018017-c8myq6bi 97 4 observations observation NNS cord-018017-c8myq6bi 97 5 : : : cord-018017-c8myq6bi 97 6 ( ( -LRB- cord-018017-c8myq6bi 97 7 1 1 LS cord-018017-c8myq6bi 97 8 ) ) -RRB- cord-018017-c8myq6bi 97 9 EID EID NNP cord-018017-c8myq6bi 97 10 is be VBZ cord-018017-c8myq6bi 97 11 a a DT cord-018017-c8myq6bi 97 12 significant significant JJ cord-018017-c8myq6bi 97 13 contemporary contemporary JJ cord-018017-c8myq6bi 97 14 concern concern NN cord-018017-c8myq6bi 97 15 , , , cord-018017-c8myq6bi 97 16 ( ( -LRB- cord-018017-c8myq6bi 97 17 2 2 LS cord-018017-c8myq6bi 97 18 ) ) -RRB- cord-018017-c8myq6bi 97 19 we -PRON- PRP cord-018017-c8myq6bi 97 20 are be VBP cord-018017-c8myq6bi 97 21 not not RB cord-018017-c8myq6bi 97 22 prepared prepared JJ cord-018017-c8myq6bi 97 23 for for IN cord-018017-c8myq6bi 97 24 the the DT cord-018017-c8myq6bi 97 25 novel novel JJ cord-018017-c8myq6bi 97 26 characteristics characteristic NNS cord-018017-c8myq6bi 97 27 introduced introduce VBN cord-018017-c8myq6bi 97 28 by by IN cord-018017-c8myq6bi 97 29 EID EID NNP cord-018017-c8myq6bi 97 30 , , , cord-018017-c8myq6bi 97 31 ( ( -LRB- cord-018017-c8myq6bi 97 32 3 3 LS cord-018017-c8myq6bi 97 33 ) ) -RRB- cord-018017-c8myq6bi 97 34 clinical clinical JJ cord-018017-c8myq6bi 97 35 signs sign NNS cord-018017-c8myq6bi 97 36 can can MD cord-018017-c8myq6bi 97 37 be be VB cord-018017-c8myq6bi 97 38 diverse diverse JJ cord-018017-c8myq6bi 97 39 and and CC cord-018017-c8myq6bi 97 40 often often RB cord-018017-c8myq6bi 97 41 mimic mimic VBP cord-018017-c8myq6bi 97 42 symptoms symptom NNS cord-018017-c8myq6bi 97 43 of of IN cord-018017-c8myq6bi 97 44 other other JJ cord-018017-c8myq6bi 97 45 diseases disease NNS cord-018017-c8myq6bi 97 46 , , , cord-018017-c8myq6bi 97 47 and and CC cord-018017-c8myq6bi 97 48 ( ( -LRB- cord-018017-c8myq6bi 97 49 4 4 LS cord-018017-c8myq6bi 97 50 ) ) -RRB- cord-018017-c8myq6bi 97 51 the the DT cord-018017-c8myq6bi 97 52 replication replication NN cord-018017-c8myq6bi 97 53 mechanisms mechanism NNS cord-018017-c8myq6bi 97 54 are be VBP cord-018017-c8myq6bi 97 55 often often RB cord-018017-c8myq6bi 97 56 error error NN cord-018017-c8myq6bi 97 57 prone prone JJ cord-018017-c8myq6bi 97 58 resulting result VBG cord-018017-c8myq6bi 97 59 in in IN cord-018017-c8myq6bi 97 60 an an DT cord-018017-c8myq6bi 97 61 array array NN cord-018017-c8myq6bi 97 62 of of IN cord-018017-c8myq6bi 97 63 fit fit JJ cord-018017-c8myq6bi 97 64 viruses virus NNS cord-018017-c8myq6bi 97 65 . . . cord-018017-c8myq6bi 98 1 Dengue dengue NN cord-018017-c8myq6bi 98 2 is be VBZ cord-018017-c8myq6bi 98 3 a a DT cord-018017-c8myq6bi 98 4 flavivirus flavivirus NN cord-018017-c8myq6bi 98 5 with with IN cord-018017-c8myq6bi 98 6 a a DT cord-018017-c8myq6bi 98 7 positive positive JJ cord-018017-c8myq6bi 98 8 sense sense NN cord-018017-c8myq6bi 98 9 single single RB cord-018017-c8myq6bi 98 10 - - HYPH cord-018017-c8myq6bi 98 11 stranded strand VBN cord-018017-c8myq6bi 98 12 RNA RNA NNP cord-018017-c8myq6bi 98 13 ( ( -LRB- cord-018017-c8myq6bi 98 14 + + CC cord-018017-c8myq6bi 98 15 ssRNA ssrna NN cord-018017-c8myq6bi 98 16 ) ) -RRB- cord-018017-c8myq6bi 98 17 genome genome NN cord-018017-c8myq6bi 98 18 carried carry VBN cord-018017-c8myq6bi 98 19 by by IN cord-018017-c8myq6bi 98 20 mosquitos mosquito NNS cord-018017-c8myq6bi 98 21 to to IN cord-018017-c8myq6bi 98 22 man man NN cord-018017-c8myq6bi 98 23 . . . cord-018017-c8myq6bi 99 1 Dengue dengue NN cord-018017-c8myq6bi 99 2 has have VBZ cord-018017-c8myq6bi 99 3 been be VBN cord-018017-c8myq6bi 99 4 a a DT cord-018017-c8myq6bi 99 5 tropical tropical JJ cord-018017-c8myq6bi 99 6 disease disease NN cord-018017-c8myq6bi 99 7 for for IN cord-018017-c8myq6bi 99 8 hundreds hundred NNS cord-018017-c8myq6bi 99 9 of of IN cord-018017-c8myq6bi 99 10 years year NNS cord-018017-c8myq6bi 99 11 , , , cord-018017-c8myq6bi 99 12 typically typically RB cord-018017-c8myq6bi 99 13 a a DT cord-018017-c8myq6bi 99 14 disease disease NN cord-018017-c8myq6bi 99 15 of of IN cord-018017-c8myq6bi 99 16 young young JJ cord-018017-c8myq6bi 99 17 children child NNS cord-018017-c8myq6bi 99 18 but but CC cord-018017-c8myq6bi 99 19 in in IN cord-018017-c8myq6bi 99 20 1953 1953 CD cord-018017-c8myq6bi 99 21 an an DT cord-018017-c8myq6bi 99 22 emerging emerge VBG cord-018017-c8myq6bi 99 23 severity severity NN cord-018017-c8myq6bi 99 24 was be VBD cord-018017-c8myq6bi 99 25 recognized recognize VBN cord-018017-c8myq6bi 99 26 in in IN cord-018017-c8myq6bi 99 27 Manila Manila NNP cord-018017-c8myq6bi 99 28 ( ( -LRB- cord-018017-c8myq6bi 99 29 Table table NN cord-018017-c8myq6bi 99 30 3 3 CD cord-018017-c8myq6bi 99 31 .3 .3 NFP cord-018017-c8myq6bi 99 32 ) ) -RRB- cord-018017-c8myq6bi 99 33 , , , cord-018017-c8myq6bi 99 34 hemorrhagic hemorrhagic JJ cord-018017-c8myq6bi 99 35 fever fever NN cord-018017-c8myq6bi 99 36 ( ( -LRB- cord-018017-c8myq6bi 99 37 DHF DHF NNP cord-018017-c8myq6bi 99 38 ) ) -RRB- cord-018017-c8myq6bi 99 39 and and CC cord-018017-c8myq6bi 99 40 dengue dengue NN cord-018017-c8myq6bi 99 41 shock shock NN cord-018017-c8myq6bi 99 42 syndrome syndrome NN cord-018017-c8myq6bi 99 43 ( ( -LRB- cord-018017-c8myq6bi 99 44 DSS DSS NNP cord-018017-c8myq6bi 99 45 ) ) -RRB- cord-018017-c8myq6bi 99 46 . . . cord-018017-c8myq6bi 100 1 More More JJR cord-018017-c8myq6bi 100 2 than than IN cord-018017-c8myq6bi 100 3 2 2 CD cord-018017-c8myq6bi 100 4 billion billion CD cord-018017-c8myq6bi 100 5 people people NNS cord-018017-c8myq6bi 100 6 are be VBP cord-018017-c8myq6bi 100 7 at at IN cord-018017-c8myq6bi 100 8 risk risk NN cord-018017-c8myq6bi 100 9 of of IN cord-018017-c8myq6bi 100 10 dengue dengue NN cord-018017-c8myq6bi 100 11 infection infection NN cord-018017-c8myq6bi 100 12 but but CC cord-018017-c8myq6bi 100 13 only only RB cord-018017-c8myq6bi 100 14 a a DT cord-018017-c8myq6bi 100 15 small small JJ cord-018017-c8myq6bi 100 16 fraction fraction NN cord-018017-c8myq6bi 100 17 of of IN cord-018017-c8myq6bi 100 18 those those DT cord-018017-c8myq6bi 100 19 infected infect VBN cord-018017-c8myq6bi 100 20 will will MD cord-018017-c8myq6bi 100 21 develop develop VB cord-018017-c8myq6bi 100 22 DHF DHF NNP cord-018017-c8myq6bi 100 23 or or CC cord-018017-c8myq6bi 100 24 DHS DHS NNP cord-018017-c8myq6bi 100 25 . . . cord-018017-c8myq6bi 101 1 Infected infected JJ cord-018017-c8myq6bi 101 2 people people NNS cord-018017-c8myq6bi 101 3 develop develop VBP cord-018017-c8myq6bi 101 4 antibodies antibody NNS cord-018017-c8myq6bi 101 5 that that WDT cord-018017-c8myq6bi 101 6 can can MD cord-018017-c8myq6bi 101 7 lead lead VB cord-018017-c8myq6bi 101 8 to to IN cord-018017-c8myq6bi 101 9 antibody antibody NN cord-018017-c8myq6bi 101 10 - - HYPH cord-018017-c8myq6bi 101 11 dependent dependent JJ cord-018017-c8myq6bi 101 12 enhancement enhancement NN cord-018017-c8myq6bi 101 13 ( ( -LRB- cord-018017-c8myq6bi 101 14 ADE ADE NNP cord-018017-c8myq6bi 101 15 ) ) -RRB- cord-018017-c8myq6bi 101 16 in in IN cord-018017-c8myq6bi 101 17 subsequent subsequent JJ cord-018017-c8myq6bi 101 18 infections infection NNS cord-018017-c8myq6bi 101 19 and and CC cord-018017-c8myq6bi 101 20 more more RBR cord-018017-c8myq6bi 101 21 severe severe JJ cord-018017-c8myq6bi 101 22 DHF DHF NNP cord-018017-c8myq6bi 101 23 or or CC cord-018017-c8myq6bi 101 24 DSS DSS NNP cord-018017-c8myq6bi 101 25 outcomes outcome NNS cord-018017-c8myq6bi 101 26 . . . cord-018017-c8myq6bi 102 1 It -PRON- PRP cord-018017-c8myq6bi 102 2 appears appear VBZ cord-018017-c8myq6bi 102 3 ADE ADE NNP cord-018017-c8myq6bi 102 4 events event NNS cord-018017-c8myq6bi 102 5 occur occur VBP cord-018017-c8myq6bi 102 6 in in IN cord-018017-c8myq6bi 102 7 people people NNS cord-018017-c8myq6bi 102 8 that that WDT cord-018017-c8myq6bi 102 9 produce produce VBP cord-018017-c8myq6bi 102 10 immunoglobins immunoglobin NNS cord-018017-c8myq6bi 102 11 ( ( -LRB- cord-018017-c8myq6bi 102 12 IgGs IgGs NNP cord-018017-c8myq6bi 102 13 ) ) -RRB- cord-018017-c8myq6bi 102 14 with with IN cord-018017-c8myq6bi 102 15 enhanced enhance VBN cord-018017-c8myq6bi 102 16 affinity affinity NN cord-018017-c8myq6bi 102 17 to to IN cord-018017-c8myq6bi 102 18 the the DT cord-018017-c8myq6bi 102 19 activating activate VBG cord-018017-c8myq6bi 102 20 Fc Fc NNP cord-018017-c8myq6bi 102 21 receptor receptor NN cord-018017-c8myq6bi 102 22 due due IN cord-018017-c8myq6bi 102 23 to to IN cord-018017-c8myq6bi 102 24 the the DT cord-018017-c8myq6bi 102 25 IgG1 igg1 XX cord-018017-c8myq6bi 102 26 subclass subclass NN cord-018017-c8myq6bi 102 27 and and CC cord-018017-c8myq6bi 102 28 lack lack NN cord-018017-c8myq6bi 102 29 of of IN cord-018017-c8myq6bi 102 30 a a DT cord-018017-c8myq6bi 102 31 fucose fucose JJ cord-018017-c8myq6bi 102 32 glycan glycan NN cord-018017-c8myq6bi 102 33 modification modification NN cord-018017-c8myq6bi 102 34 of of IN cord-018017-c8myq6bi 102 35 the the DT cord-018017-c8myq6bi 102 36 IgG IgG NNP cord-018017-c8myq6bi 103 1 ( ( -LRB- cord-018017-c8myq6bi 103 2 Wang Wang NNP cord-018017-c8myq6bi 103 3 et et NNP cord-018017-c8myq6bi 103 4 al al NNP cord-018017-c8myq6bi 103 5 . . . cord-018017-c8myq6bi 103 6 2017 2017 CD cord-018017-c8myq6bi 103 7 ) ) -RRB- cord-018017-c8myq6bi 104 1 Aedes Aedes NNP cord-018017-c8myq6bi 104 2 aegypti aegypti NN cord-018017-c8myq6bi 104 3 is be VBZ cord-018017-c8myq6bi 104 4 the the DT cord-018017-c8myq6bi 104 5 primary primary JJ cord-018017-c8myq6bi 104 6 vector vector NN cord-018017-c8myq6bi 104 7 transmitting transmit VBG cord-018017-c8myq6bi 104 8 dengue dengue NN cord-018017-c8myq6bi 104 9 but but CC cord-018017-c8myq6bi 104 10 a a DT cord-018017-c8myq6bi 104 11 new new JJ cord-018017-c8myq6bi 104 12 vector vector NN cord-018017-c8myq6bi 104 13 , , , cord-018017-c8myq6bi 104 14 Aedes Aedes NNP cord-018017-c8myq6bi 104 15 albopictus albopictus NN cord-018017-c8myq6bi 104 16 , , , cord-018017-c8myq6bi 104 17 now now RB cord-018017-c8myq6bi 104 18 carries carry VBZ cord-018017-c8myq6bi 104 19 dengue dengue NN cord-018017-c8myq6bi 104 20 to to IN cord-018017-c8myq6bi 104 21 the the DT cord-018017-c8myq6bi 104 22 southern southern JJ cord-018017-c8myq6bi 104 23 United United NNP cord-018017-c8myq6bi 104 24 States States NNP cord-018017-c8myq6bi 104 25 . . . cord-018017-c8myq6bi 105 1 Emergence emergence NN cord-018017-c8myq6bi 105 2 of of IN cord-018017-c8myq6bi 105 3 dengue dengue NN cord-018017-c8myq6bi 105 4 in in IN cord-018017-c8myq6bi 105 5 the the DT cord-018017-c8myq6bi 105 6 southern southern JJ cord-018017-c8myq6bi 105 7 United United NNP cord-018017-c8myq6bi 105 8 States States NNP cord-018017-c8myq6bi 105 9 is be VBZ cord-018017-c8myq6bi 105 10 likely likely JJ cord-018017-c8myq6bi 105 11 due due JJ cord-018017-c8myq6bi 105 12 to to IN cord-018017-c8myq6bi 105 13 used use VBN cord-018017-c8myq6bi 105 14 tires tire NNS cord-018017-c8myq6bi 105 15 imported import VBN cord-018017-c8myq6bi 105 16 from from IN cord-018017-c8myq6bi 105 17 Japan Japan NNP cord-018017-c8myq6bi 105 18 which which WDT cord-018017-c8myq6bi 105 19 provided provide VBD cord-018017-c8myq6bi 105 20 a a DT cord-018017-c8myq6bi 105 21 place place NN cord-018017-c8myq6bi 105 22 for for IN cord-018017-c8myq6bi 105 23 the the DT cord-018017-c8myq6bi 105 24 Asian asian JJ cord-018017-c8myq6bi 105 25 tiger tiger NN cord-018017-c8myq6bi 105 26 mosquito mosquito NN cord-018017-c8myq6bi 105 27 to to TO cord-018017-c8myq6bi 105 28 live live VB cord-018017-c8myq6bi 105 29 . . . cord-018017-c8myq6bi 106 1 Outbreaks outbreak NNS cord-018017-c8myq6bi 106 2 of of IN cord-018017-c8myq6bi 106 3 dengue dengue NN cord-018017-c8myq6bi 106 4 fever fever NN cord-018017-c8myq6bi 106 5 have have VBP cord-018017-c8myq6bi 106 6 become become VBN cord-018017-c8myq6bi 106 7 more more RBR cord-018017-c8myq6bi 106 8 numerous numerous JJ cord-018017-c8myq6bi 106 9 and and CC cord-018017-c8myq6bi 106 10 more more RBR cord-018017-c8myq6bi 106 11 severe severe JJ cord-018017-c8myq6bi 106 12 over over IN cord-018017-c8myq6bi 106 13 the the DT cord-018017-c8myq6bi 106 14 past past JJ cord-018017-c8myq6bi 106 15 three three CD cord-018017-c8myq6bi 106 16 decades decade NNS cord-018017-c8myq6bi 106 17 . . . cord-018017-c8myq6bi 107 1 Viral viral JJ cord-018017-c8myq6bi 107 2 " " `` cord-018017-c8myq6bi 107 3 fitness fitness NN cord-018017-c8myq6bi 107 4 " " '' cord-018017-c8myq6bi 107 5 is be VBZ cord-018017-c8myq6bi 107 6 constrained constrain VBN cord-018017-c8myq6bi 107 7 by by IN cord-018017-c8myq6bi 107 8 the the DT cord-018017-c8myq6bi 107 9 requirements requirement NNS cord-018017-c8myq6bi 107 10 imposed impose VBN cord-018017-c8myq6bi 107 11 by by IN cord-018017-c8myq6bi 107 12 the the DT cord-018017-c8myq6bi 107 13 natural natural JJ cord-018017-c8myq6bi 107 14 host host NN cord-018017-c8myq6bi 107 15 so so IN cord-018017-c8myq6bi 107 16 that that IN cord-018017-c8myq6bi 107 17 it -PRON- PRP cord-018017-c8myq6bi 107 18 is be VBZ cord-018017-c8myq6bi 107 19 a a DT cord-018017-c8myq6bi 107 20 low low JJ cord-018017-c8myq6bi 107 21 probability probability NN cord-018017-c8myq6bi 107 22 event event NN cord-018017-c8myq6bi 107 23 for for IN cord-018017-c8myq6bi 107 24 a a DT cord-018017-c8myq6bi 107 25 virus virus NN cord-018017-c8myq6bi 107 26 to to TO cord-018017-c8myq6bi 107 27 move move VB cord-018017-c8myq6bi 107 28 from from IN cord-018017-c8myq6bi 107 29 the the DT cord-018017-c8myq6bi 107 30 natural natural JJ cord-018017-c8myq6bi 107 31 host host NN cord-018017-c8myq6bi 107 32 to to IN cord-018017-c8myq6bi 107 33 a a DT cord-018017-c8myq6bi 107 34 human human NN cord-018017-c8myq6bi 107 35 . . . cord-018017-c8myq6bi 108 1 While while IN cord-018017-c8myq6bi 108 2 an an DT cord-018017-c8myq6bi 108 3 insect insect NN cord-018017-c8myq6bi 108 4 frequently frequently RB cord-018017-c8myq6bi 108 5 plays play VBZ cord-018017-c8myq6bi 108 6 the the DT cord-018017-c8myq6bi 108 7 role role NN cord-018017-c8myq6bi 108 8 of of IN cord-018017-c8myq6bi 108 9 vector vector NN cord-018017-c8myq6bi 108 10 carrying carry VBG cord-018017-c8myq6bi 108 11 a a DT cord-018017-c8myq6bi 108 12 virus virus NN cord-018017-c8myq6bi 108 13 from from IN cord-018017-c8myq6bi 108 14 an an DT cord-018017-c8myq6bi 108 15 animal animal NN cord-018017-c8myq6bi 108 16 reservoir reservoir NN cord-018017-c8myq6bi 108 17 to to IN cord-018017-c8myq6bi 108 18 humans human NNS cord-018017-c8myq6bi 108 19 , , , cord-018017-c8myq6bi 108 20 several several JJ cord-018017-c8myq6bi 108 21 zoonotic zoonotic JJ cord-018017-c8myq6bi 108 22 viruses virus NNS cord-018017-c8myq6bi 108 23 are be VBP cord-018017-c8myq6bi 108 24 transmitted transmit VBN cord-018017-c8myq6bi 108 25 by by IN cord-018017-c8myq6bi 108 26 placing place VBG cord-018017-c8myq6bi 108 27 humans human NNS cord-018017-c8myq6bi 108 28 near near IN cord-018017-c8myq6bi 108 29 rodents rodent NNS cord-018017-c8myq6bi 108 30 . . . cord-018017-c8myq6bi 109 1 Several several JJ cord-018017-c8myq6bi 109 2 arenaviruses arenavirus NNS cord-018017-c8myq6bi 109 3 , , , cord-018017-c8myq6bi 109 4 minus minus CC cord-018017-c8myq6bi 109 5 sense sense NN cord-018017-c8myq6bi 109 6 single single RB cord-018017-c8myq6bi 109 7 - - HYPH cord-018017-c8myq6bi 109 8 stranded strand VBN cord-018017-c8myq6bi 109 9 RNA RNA NNP cord-018017-c8myq6bi 109 10 viruses virus NNS cord-018017-c8myq6bi 109 11 , , , cord-018017-c8myq6bi 109 12 jump jump VB cord-018017-c8myq6bi 109 13 from from IN cord-018017-c8myq6bi 109 14 their -PRON- PRP$ cord-018017-c8myq6bi 109 15 rodent rodent NN cord-018017-c8myq6bi 109 16 natural natural JJ cord-018017-c8myq6bi 109 17 hosts host NNS cord-018017-c8myq6bi 109 18 directly directly RB cord-018017-c8myq6bi 109 19 to to IN cord-018017-c8myq6bi 109 20 humans human NNS cord-018017-c8myq6bi 109 21 through through IN cord-018017-c8myq6bi 109 22 contact contact NN cord-018017-c8myq6bi 109 23 with with IN cord-018017-c8myq6bi 109 24 rodent rodent NN cord-018017-c8myq6bi 109 25 urine urine NN cord-018017-c8myq6bi 109 26 or or CC cord-018017-c8myq6bi 109 27 saliva saliva NN cord-018017-c8myq6bi 109 28 . . . cord-018017-c8myq6bi 110 1 Notable notable JJ cord-018017-c8myq6bi 110 2 arenaviruses arenavirus NNS cord-018017-c8myq6bi 110 3 are be VBP cord-018017-c8myq6bi 110 4 named name VBN cord-018017-c8myq6bi 110 5 for for IN cord-018017-c8myq6bi 110 6 the the DT cord-018017-c8myq6bi 110 7 hemorrhagic hemorrhagic JJ cord-018017-c8myq6bi 110 8 fever fever NN cord-018017-c8myq6bi 110 9 ( ( -LRB- cord-018017-c8myq6bi 110 10 HF HF NNP cord-018017-c8myq6bi 110 11 ) ) -RRB- cord-018017-c8myq6bi 110 12 region region NN cord-018017-c8myq6bi 110 13 of of IN cord-018017-c8myq6bi 110 14 their -PRON- PRP$ cord-018017-c8myq6bi 110 15 zoonosis zoonosis NN cord-018017-c8myq6bi 110 16 ; ; : cord-018017-c8myq6bi 110 17 Bolivian bolivian JJ cord-018017-c8myq6bi 110 18 HF HF NNP cord-018017-c8myq6bi 110 19 is be VBZ cord-018017-c8myq6bi 110 20 caused cause VBN cord-018017-c8myq6bi 110 21 by by IN cord-018017-c8myq6bi 110 22 Machupo Machupo NNP cord-018017-c8myq6bi 110 23 ( ( -LRB- cord-018017-c8myq6bi 110 24 MACV MACV NNP cord-018017-c8myq6bi 110 25 ) ) -RRB- cord-018017-c8myq6bi 111 1 , , , cord-018017-c8myq6bi 111 2 Argentine Argentine NNP cord-018017-c8myq6bi 111 3 HF HF NNP cord-018017-c8myq6bi 111 4 is be VBZ cord-018017-c8myq6bi 111 5 caused cause VBN cord-018017-c8myq6bi 111 6 by by IN cord-018017-c8myq6bi 111 7 Junin Junin NNP cord-018017-c8myq6bi 111 8 ( ( -LRB- cord-018017-c8myq6bi 111 9 JUNV JUNV NNP cord-018017-c8myq6bi 111 10 ) ) -RRB- cord-018017-c8myq6bi 111 11 and and CC cord-018017-c8myq6bi 111 12 Venezuelan Venezuelan NNP cord-018017-c8myq6bi 111 13 HF HF NNP cord-018017-c8myq6bi 111 14 is be VBZ cord-018017-c8myq6bi 111 15 caused cause VBN cord-018017-c8myq6bi 111 16 by by IN cord-018017-c8myq6bi 111 17 Guanarito Guanarito NNP cord-018017-c8myq6bi 111 18 ( ( -LRB- cord-018017-c8myq6bi 111 19 GOTV GOTV NNP cord-018017-c8myq6bi 111 20 ) ) -RRB- cord-018017-c8myq6bi 111 21 . . . cord-018017-c8myq6bi 112 1 These these DT cord-018017-c8myq6bi 112 2 South south JJ cord-018017-c8myq6bi 112 3 American american JJ cord-018017-c8myq6bi 112 4 outbreaks outbreak NNS cord-018017-c8myq6bi 112 5 are be VBP cord-018017-c8myq6bi 112 6 caused cause VBN cord-018017-c8myq6bi 112 7 by by IN cord-018017-c8myq6bi 112 8 new new JJ cord-018017-c8myq6bi 112 9 world world NN cord-018017-c8myq6bi 112 10 arenaviruses arenavirus NNS cord-018017-c8myq6bi 112 11 in in IN cord-018017-c8myq6bi 112 12 contrast contrast NN cord-018017-c8myq6bi 112 13 to to IN cord-018017-c8myq6bi 112 14 Lassa Lassa NNP cord-018017-c8myq6bi 112 15 HF HF NNP cord-018017-c8myq6bi 112 16 ( ( -LRB- cord-018017-c8myq6bi 112 17 LASV LASV NNP cord-018017-c8myq6bi 112 18 ) ) -RRB- cord-018017-c8myq6bi 112 19 , , , cord-018017-c8myq6bi 112 20 an an DT cord-018017-c8myq6bi 112 21 African african JJ cord-018017-c8myq6bi 112 22 or or CC cord-018017-c8myq6bi 112 23 old old JJ cord-018017-c8myq6bi 112 24 world world NN cord-018017-c8myq6bi 112 25 arenavirus arenavirus NNP cord-018017-c8myq6bi 112 26 . . . cord-018017-c8myq6bi 113 1 LASV LASV NNP cord-018017-c8myq6bi 113 2 is be VBZ cord-018017-c8myq6bi 113 3 an an DT cord-018017-c8myq6bi 113 4 endemic endemic JJ cord-018017-c8myq6bi 113 5 disease disease NN cord-018017-c8myq6bi 113 6 of of IN cord-018017-c8myq6bi 113 7 West West NNP cord-018017-c8myq6bi 113 8 Africa Africa NNP cord-018017-c8myq6bi 113 9 ( ( -LRB- cord-018017-c8myq6bi 113 10 Table table NN cord-018017-c8myq6bi 113 11 3 3 CD cord-018017-c8myq6bi 113 12 .3 .3 NFP cord-018017-c8myq6bi 113 13 ) ) -RRB- cord-018017-c8myq6bi 113 14 and and CC cord-018017-c8myq6bi 113 15 can can MD cord-018017-c8myq6bi 113 16 be be VB cord-018017-c8myq6bi 113 17 confused confuse VBN cord-018017-c8myq6bi 113 18 with with IN cord-018017-c8myq6bi 113 19 DHF DHF NNP cord-018017-c8myq6bi 113 20 or or CC cord-018017-c8myq6bi 113 21 Ebola Ebola NNP cord-018017-c8myq6bi 113 22 infections infection NNS cord-018017-c8myq6bi 113 23 . . . cord-018017-c8myq6bi 114 1 Viruses virus NNS cord-018017-c8myq6bi 114 2 that that WDT cord-018017-c8myq6bi 114 3 are be VBP cord-018017-c8myq6bi 114 4 transmitted transmit VBN cord-018017-c8myq6bi 114 5 by by IN cord-018017-c8myq6bi 114 6 arthropod arthropod JJ cord-018017-c8myq6bi 114 7 vectors vector NNS cord-018017-c8myq6bi 114 8 are be VBP cord-018017-c8myq6bi 114 9 called call VBN cord-018017-c8myq6bi 114 10 arboviruses arbovirus NNS cord-018017-c8myq6bi 114 11 . . . cord-018017-c8myq6bi 115 1 In in IN cord-018017-c8myq6bi 115 2 1930 1930 CD cord-018017-c8myq6bi 115 3 , , , cord-018017-c8myq6bi 115 4 only only RB cord-018017-c8myq6bi 115 5 yellow yellow JJ cord-018017-c8myq6bi 115 6 fever fever NN cord-018017-c8myq6bi 115 7 of of IN cord-018017-c8myq6bi 115 8 six six CD cord-018017-c8myq6bi 115 9 known know VBN cord-018017-c8myq6bi 115 10 arboviruses arbovirus NNS cord-018017-c8myq6bi 115 11 caused cause VBD cord-018017-c8myq6bi 115 12 disease disease NN cord-018017-c8myq6bi 115 13 in in IN cord-018017-c8myq6bi 115 14 humans human NNS cord-018017-c8myq6bi 115 15 . . . cord-018017-c8myq6bi 116 1 The the DT cord-018017-c8myq6bi 116 2 discovery discovery NN cord-018017-c8myq6bi 116 3 of of IN cord-018017-c8myq6bi 116 4 arbovirus arbovirus NNP cord-018017-c8myq6bi 116 5 caused cause VBD cord-018017-c8myq6bi 116 6 human human JJ cord-018017-c8myq6bi 116 7 disease disease NN cord-018017-c8myq6bi 116 8 expanded expand VBN cord-018017-c8myq6bi 116 9 beginning beginning NN cord-018017-c8myq6bi 116 10 in in IN cord-018017-c8myq6bi 116 11 the the DT cord-018017-c8myq6bi 116 12 late late JJ cord-018017-c8myq6bi 116 13 1930s 1930 NNS cord-018017-c8myq6bi 116 14 with with IN cord-018017-c8myq6bi 116 15 western western JJ cord-018017-c8myq6bi 116 16 and and CC cord-018017-c8myq6bi 116 17 eastern eastern JJ cord-018017-c8myq6bi 116 18 equine equine JJ cord-018017-c8myq6bi 116 19 encephalomyelitis encephalomyelitis NN cord-018017-c8myq6bi 116 20 ( ( -LRB- cord-018017-c8myq6bi 116 21 WEEV WEEV NNP cord-018017-c8myq6bi 116 22 , , , cord-018017-c8myq6bi 116 23 EEEV EEEV NNP cord-018017-c8myq6bi 116 24 ) ) -RRB- cord-018017-c8myq6bi 116 25 and and CC cord-018017-c8myq6bi 116 26 St. St. NNP cord-018017-c8myq6bi 116 27 Louis Louis NNP cord-018017-c8myq6bi 116 28 encephalitis encephalitis RB cord-018017-c8myq6bi 116 29 . . . cord-018017-c8myq6bi 117 1 Both both DT cord-018017-c8myq6bi 117 2 Chickungunya Chickungunya NNP cord-018017-c8myq6bi 117 3 and and CC cord-018017-c8myq6bi 117 4 Zika Zika NNP cord-018017-c8myq6bi 117 5 ( ( -LRB- cord-018017-c8myq6bi 117 6 Table table NN cord-018017-c8myq6bi 117 7 3 3 CD cord-018017-c8myq6bi 117 8 .4 .4 NFP cord-018017-c8myq6bi 117 9 ) ) -RRB- cord-018017-c8myq6bi 117 10 are be VBP cord-018017-c8myq6bi 117 11 arboviruses arbovirus NNS cord-018017-c8myq6bi 117 12 that that WDT cord-018017-c8myq6bi 117 13 have have VBP cord-018017-c8myq6bi 117 14 emerged emerge VBN cord-018017-c8myq6bi 117 15 to to TO cord-018017-c8myq6bi 117 16 become become VB cord-018017-c8myq6bi 117 17 global global JJ cord-018017-c8myq6bi 117 18 infections infection NNS cord-018017-c8myq6bi 117 19 in in IN cord-018017-c8myq6bi 117 20 the the DT cord-018017-c8myq6bi 117 21 twenty twenty CD cord-018017-c8myq6bi 117 22 - - HYPH cord-018017-c8myq6bi 117 23 first first JJ cord-018017-c8myq6bi 117 24 century century NN cord-018017-c8myq6bi 117 25 . . . cord-018017-c8myq6bi 118 1 Zika Zika NNP cord-018017-c8myq6bi 118 2 not not RB cord-018017-c8myq6bi 118 3 only only RB cord-018017-c8myq6bi 118 4 became become VBD cord-018017-c8myq6bi 118 5 infamous infamous JJ cord-018017-c8myq6bi 118 6 for for IN cord-018017-c8myq6bi 118 7 causing cause VBG cord-018017-c8myq6bi 118 8 microcephaly microcephaly NNS cord-018017-c8myq6bi 118 9 in in IN cord-018017-c8myq6bi 118 10 newborns newborn NNS cord-018017-c8myq6bi 118 11 of of IN cord-018017-c8myq6bi 118 12 infected infected JJ cord-018017-c8myq6bi 118 13 mothers mother NNS cord-018017-c8myq6bi 118 14 and and CC cord-018017-c8myq6bi 118 15 Guillain Guillain NNP cord-018017-c8myq6bi 118 16 - - HYPH cord-018017-c8myq6bi 118 17 Barre Barre NNP cord-018017-c8myq6bi 118 18 syndrome syndrome NN cord-018017-c8myq6bi 118 19 but but CC cord-018017-c8myq6bi 118 20 is be VBZ cord-018017-c8myq6bi 118 21 now now RB cord-018017-c8myq6bi 118 22 sexually sexually RB cord-018017-c8myq6bi 118 23 transmitted transmit VBN cord-018017-c8myq6bi 118 24 between between IN cord-018017-c8myq6bi 118 25 humans human NNS cord-018017-c8myq6bi 118 26 . . . cord-018017-c8myq6bi 119 1 I -PRON- PRP cord-018017-c8myq6bi 119 2 worked work VBD cord-018017-c8myq6bi 119 3 on on IN cord-018017-c8myq6bi 119 4 a a DT cord-018017-c8myq6bi 119 5 therapeutic therapeutic JJ cord-018017-c8myq6bi 119 6 for for IN cord-018017-c8myq6bi 119 7 the the DT cord-018017-c8myq6bi 119 8 treatment treatment NN cord-018017-c8myq6bi 119 9 of of IN cord-018017-c8myq6bi 119 10 Ebola Ebola NNP cord-018017-c8myq6bi 119 11 infections infection NNS cord-018017-c8myq6bi 119 12 from from IN cord-018017-c8myq6bi 119 13 2007 2007 CD cord-018017-c8myq6bi 119 14 to to IN cord-018017-c8myq6bi 119 15 2013 2013 CD cord-018017-c8myq6bi 119 16 . . . cord-018017-c8myq6bi 120 1 The the DT cord-018017-c8myq6bi 120 2 genome genome NN cord-018017-c8myq6bi 120 3 sequence sequence NN cord-018017-c8myq6bi 120 4 recovered recover VBN cord-018017-c8myq6bi 120 5 from from IN cord-018017-c8myq6bi 120 6 each each DT cord-018017-c8myq6bi 120 7 outbreak outbreak NN cord-018017-c8myq6bi 120 8 from from IN cord-018017-c8myq6bi 120 9 1976 1976 CD cord-018017-c8myq6bi 120 10 to to IN cord-018017-c8myq6bi 120 11 2013 2013 CD cord-018017-c8myq6bi 120 12 has have VBZ cord-018017-c8myq6bi 120 13 been be VBN cord-018017-c8myq6bi 120 14 different different JJ cord-018017-c8myq6bi 120 15 . . . cord-018017-c8myq6bi 121 1 Studies study NNS cord-018017-c8myq6bi 121 2 were be VBD cord-018017-c8myq6bi 121 3 conducted conduct VBN cord-018017-c8myq6bi 121 4 at at IN cord-018017-c8myq6bi 121 5 USAMRIID USAMRIID NNP cord-018017-c8myq6bi 121 6 in in IN cord-018017-c8myq6bi 121 7 their -PRON- PRP$ cord-018017-c8myq6bi 121 8 BSL4 BSL4 NNP cord-018017-c8myq6bi 121 9 facility facility NN cord-018017-c8myq6bi 121 10 by by IN cord-018017-c8myq6bi 121 11 expert expert NN cord-018017-c8myq6bi 121 12 Ebola Ebola NNP cord-018017-c8myq6bi 121 13 investigators investigator NNS cord-018017-c8myq6bi 121 14 . . . cord-018017-c8myq6bi 122 1 Rhesus rhesus NN cord-018017-c8myq6bi 122 2 monkeys monkey NNS cord-018017-c8myq6bi 122 3 ( ( -LRB- cord-018017-c8myq6bi 122 4 Macaca Macaca NNP cord-018017-c8myq6bi 122 5 mulatta mulatta NN cord-018017-c8myq6bi 122 6 ) ) -RRB- cord-018017-c8myq6bi 122 7 were be VBD cord-018017-c8myq6bi 122 8 injected inject VBN cord-018017-c8myq6bi 122 9 with with IN cord-018017-c8myq6bi 122 10 1000 1000 CD cord-018017-c8myq6bi 122 11 plaque plaque NN cord-018017-c8myq6bi 122 12 forming form VBG cord-018017-c8myq6bi 122 13 units unit NNS cord-018017-c8myq6bi 122 14 ( ( -LRB- cord-018017-c8myq6bi 122 15 pfu pfu NN cord-018017-c8myq6bi 122 16 ) ) -RRB- cord-018017-c8myq6bi 122 17 of of IN cord-018017-c8myq6bi 122 18 Zaire Zaire NNP cord-018017-c8myq6bi 122 19 ebolavirus ebolavirus NN cord-018017-c8myq6bi 122 20 ( ( -LRB- cord-018017-c8myq6bi 122 21 ZEBOV ZEBOV NNP cord-018017-c8myq6bi 122 22 ) ) -RRB- cord-018017-c8myq6bi 122 23 Kikwit Kikwit NNP cord-018017-c8myq6bi 122 24 into into IN cord-018017-c8myq6bi 122 25 their -PRON- PRP$ cord-018017-c8myq6bi 122 26 thigh thigh NN cord-018017-c8myq6bi 122 27 muscle muscle NN cord-018017-c8myq6bi 122 28 . . . cord-018017-c8myq6bi 123 1 All all DT cord-018017-c8myq6bi 123 2 of of IN cord-018017-c8myq6bi 123 3 the the DT cord-018017-c8myq6bi 123 4 untreated untreated JJ cord-018017-c8myq6bi 123 5 control control NN cord-018017-c8myq6bi 123 6 monkeys monkey NNS cord-018017-c8myq6bi 123 7 died die VBD cord-018017-c8myq6bi 123 8 between between IN cord-018017-c8myq6bi 123 9 days day NNS cord-018017-c8myq6bi 123 10 8 8 CD cord-018017-c8myq6bi 123 11 and and CC cord-018017-c8myq6bi 123 12 10 10 CD cord-018017-c8myq6bi 123 13 following follow VBG cord-018017-c8myq6bi 123 14 viral viral JJ cord-018017-c8myq6bi 123 15 injection injection NN cord-018017-c8myq6bi 123 16 . . . cord-018017-c8myq6bi 124 1 We -PRON- PRP cord-018017-c8myq6bi 124 2 measured measure VBD cord-018017-c8myq6bi 124 3 viral viral JJ cord-018017-c8myq6bi 124 4 burden burden NN cord-018017-c8myq6bi 124 5 by by IN cord-018017-c8myq6bi 124 6 quantitative quantitative JJ cord-018017-c8myq6bi 124 7 polymerase polymerase NN cord-018017-c8myq6bi 124 8 chain chain NN cord-018017-c8myq6bi 124 9 reaction reaction NN cord-018017-c8myq6bi 124 10 ( ( -LRB- cord-018017-c8myq6bi 124 11 qRT qRT NNP cord-018017-c8myq6bi 124 12 PCR PCR NNP cord-018017-c8myq6bi 124 13 ) ) -RRB- cord-018017-c8myq6bi 125 1 a a DT cord-018017-c8myq6bi 125 2 measure measure NN cord-018017-c8myq6bi 125 3 of of IN cord-018017-c8myq6bi 125 4 genome genome NN cord-018017-c8myq6bi 125 5 copies copy NNS cord-018017-c8myq6bi 125 6 per per IN cord-018017-c8myq6bi 125 7 milliliter milliliter NN cord-018017-c8myq6bi 125 8 ( ( -LRB- cord-018017-c8myq6bi 125 9 copies copy NNS cord-018017-c8myq6bi 125 10 / / SYM cord-018017-c8myq6bi 125 11 mL ml NN cord-018017-c8myq6bi 125 12 ) ) -RRB- cord-018017-c8myq6bi 125 13 of of IN cord-018017-c8myq6bi 125 14 plasma plasma NN cord-018017-c8myq6bi 125 15 and and CC cord-018017-c8myq6bi 125 16 plaque plaque NN cord-018017-c8myq6bi 125 17 formation formation NN cord-018017-c8myq6bi 125 18 a a DT cord-018017-c8myq6bi 125 19 measure measure NN cord-018017-c8myq6bi 125 20 of of IN cord-018017-c8myq6bi 125 21 infectious infectious JJ cord-018017-c8myq6bi 125 22 viruses virus NNS cord-018017-c8myq6bi 125 23 per per IN cord-018017-c8myq6bi 125 24 mL ml NN cord-018017-c8myq6bi 125 25 ( ( -LRB- cord-018017-c8myq6bi 125 26 pfu pfu NN cord-018017-c8myq6bi 125 27 / / SYM cord-018017-c8myq6bi 125 28 mL ml NN cord-018017-c8myq6bi 125 29 ) ) -RRB- cord-018017-c8myq6bi 125 30 plasma plasma NN cord-018017-c8myq6bi 125 31 . . . cord-018017-c8myq6bi 126 1 We -PRON- PRP cord-018017-c8myq6bi 126 2 found find VBD cord-018017-c8myq6bi 126 3 an an DT cord-018017-c8myq6bi 126 4 average average NN cord-018017-c8myq6bi 126 5 of of IN cord-018017-c8myq6bi 126 6 1.7x10 1.7x10 CD cord-018017-c8myq6bi 126 7 8 8 CD cord-018017-c8myq6bi 126 8 genome genome NN cord-018017-c8myq6bi 126 9 copies copy NNS cord-018017-c8myq6bi 126 10 per per IN cord-018017-c8myq6bi 126 11 mL ml NN cord-018017-c8myq6bi 126 12 on on IN cord-018017-c8myq6bi 126 13 day day NN cord-018017-c8myq6bi 126 14 8 8 CD cord-018017-c8myq6bi 126 15 post post NN cord-018017-c8myq6bi 126 16 infection infection NN cord-018017-c8myq6bi 126 17 and and CC cord-018017-c8myq6bi 126 18 1.2x10 1.2x10 CD cord-018017-c8myq6bi 126 19 6 6 CD cord-018017-c8myq6bi 126 20 pfu pfu NN cord-018017-c8myq6bi 126 21 / / SYM cord-018017-c8myq6bi 126 22 mL ml NN cord-018017-c8myq6bi 126 23 on on IN cord-018017-c8myq6bi 126 24 day day NN cord-018017-c8myq6bi 126 25 8 8 CD cord-018017-c8myq6bi 126 26 . . . cord-018017-c8myq6bi 127 1 Nearly nearly RB cord-018017-c8myq6bi 127 2 100 100 CD cord-018017-c8myq6bi 127 3 genomes genome NNS cord-018017-c8myq6bi 127 4 present present JJ cord-018017-c8myq6bi 127 5 for for IN cord-018017-c8myq6bi 127 6 each each DT cord-018017-c8myq6bi 127 7 successful successful JJ cord-018017-c8myq6bi 127 8 virus virus NN cord-018017-c8myq6bi 127 9 in in IN cord-018017-c8myq6bi 127 10 a a DT cord-018017-c8myq6bi 127 11 nonhuvwas nonhuvwas NN cord-018017-c8myq6bi 127 12 not not RB cord-018017-c8myq6bi 127 13 observed observe VBN cord-018017-c8myq6bi 127 14 , , , cord-018017-c8myq6bi 127 15 the the DT cord-018017-c8myq6bi 127 16 dominant dominant JJ cord-018017-c8myq6bi 127 17 population population NN cord-018017-c8myq6bi 127 18 of of IN cord-018017-c8myq6bi 127 19 viral viral JJ cord-018017-c8myq6bi 127 20 genome genome NN cord-018017-c8myq6bi 127 21 sequence sequence NN cord-018017-c8myq6bi 127 22 did do VBD cord-018017-c8myq6bi 127 23 not not RB cord-018017-c8myq6bi 127 24 change change VB cord-018017-c8myq6bi 127 25 from from IN cord-018017-c8myq6bi 127 26 one one CD cord-018017-c8myq6bi 127 27 individual individual NN cord-018017-c8myq6bi 127 28 to to IN cord-018017-c8myq6bi 127 29 another another DT cord-018017-c8myq6bi 127 30 or or CC cord-018017-c8myq6bi 127 31 from from IN cord-018017-c8myq6bi 127 32 one one CD cord-018017-c8myq6bi 127 33 time time NN cord-018017-c8myq6bi 127 34 to to IN cord-018017-c8myq6bi 127 35 another another DT cord-018017-c8myq6bi 127 36 within within IN cord-018017-c8myq6bi 127 37 the the DT cord-018017-c8myq6bi 127 38 same same JJ cord-018017-c8myq6bi 127 39 individual individual NN cord-018017-c8myq6bi 127 40 . . . cord-018017-c8myq6bi 128 1 The the DT cord-018017-c8myq6bi 128 2 existence existence NN cord-018017-c8myq6bi 128 3 of of IN cord-018017-c8myq6bi 128 4 defective defective JJ cord-018017-c8myq6bi 128 5 viral viral JJ cord-018017-c8myq6bi 128 6 genomes genome NNS cord-018017-c8myq6bi 128 7 may may MD cord-018017-c8myq6bi 128 8 offer offer VB cord-018017-c8myq6bi 128 9 potential potential NN cord-018017-c8myq6bi 128 10 for for IN cord-018017-c8myq6bi 128 11 rapid rapid JJ cord-018017-c8myq6bi 128 12 change change NN cord-018017-c8myq6bi 128 13 but but CC cord-018017-c8myq6bi 128 14 in in IN cord-018017-c8myq6bi 128 15 a a DT cord-018017-c8myq6bi 128 16 stable stable JJ cord-018017-c8myq6bi 128 17 host host NN cord-018017-c8myq6bi 128 18 , , , cord-018017-c8myq6bi 128 19 change change NN cord-018017-c8myq6bi 128 20 was be VBD cord-018017-c8myq6bi 128 21 not not RB cord-018017-c8myq6bi 128 22 rapid rapid JJ cord-018017-c8myq6bi 128 23 . . . cord-018017-c8myq6bi 129 1 When when WRB cord-018017-c8myq6bi 129 2 one one PRP cord-018017-c8myq6bi 129 3 considers consider VBZ cord-018017-c8myq6bi 129 4 the the DT cord-018017-c8myq6bi 129 5 magnitude magnitude NN cord-018017-c8myq6bi 129 6 of of IN cord-018017-c8myq6bi 129 7 differences difference NNS cord-018017-c8myq6bi 129 8 in in IN cord-018017-c8myq6bi 129 9 conditions condition NNS cord-018017-c8myq6bi 129 10 as as IN cord-018017-c8myq6bi 129 11 a a DT cord-018017-c8myq6bi 129 12 virus virus NN cord-018017-c8myq6bi 129 13 jumps jump VBZ cord-018017-c8myq6bi 129 14 from from IN cord-018017-c8myq6bi 129 15 a a DT cord-018017-c8myq6bi 129 16 reservoir reservoir NN cord-018017-c8myq6bi 129 17 host host NN cord-018017-c8myq6bi 129 18 to to IN cord-018017-c8myq6bi 129 19 a a DT cord-018017-c8myq6bi 129 20 human human JJ cord-018017-c8myq6bi 129 21 , , , cord-018017-c8myq6bi 129 22 rapid rapid JJ cord-018017-c8myq6bi 129 23 adaptability adaptability NN cord-018017-c8myq6bi 129 24 is be VBZ cord-018017-c8myq6bi 129 25 a a DT cord-018017-c8myq6bi 129 26 great great JJ cord-018017-c8myq6bi 129 27 advantage advantage NN cord-018017-c8myq6bi 129 28 . . . cord-018017-c8myq6bi 130 1 A a DT cord-018017-c8myq6bi 130 2 virus virus NN cord-018017-c8myq6bi 130 3 that that WDT cord-018017-c8myq6bi 130 4 kills kill VBZ cord-018017-c8myq6bi 130 5 all all PDT cord-018017-c8myq6bi 130 6 the the DT cord-018017-c8myq6bi 130 7 hosts host NNS cord-018017-c8myq6bi 130 8 is be VBZ cord-018017-c8myq6bi 130 9 not not RB cord-018017-c8myq6bi 130 10 a a DT cord-018017-c8myq6bi 130 11 successful successful JJ cord-018017-c8myq6bi 130 12 virus virus NN cord-018017-c8myq6bi 130 13 . . . cord-018017-c8myq6bi 131 1 Perhaps perhaps RB cord-018017-c8myq6bi 131 2 defective defective JJ cord-018017-c8myq6bi 131 3 viral viral JJ cord-018017-c8myq6bi 131 4 particles particle NNS cord-018017-c8myq6bi 131 5 facilitate facilitate VBP cord-018017-c8myq6bi 131 6 host host NN cord-018017-c8myq6bi 131 7 immune immune JJ cord-018017-c8myq6bi 131 8 responses response NNS cord-018017-c8myq6bi 131 9 giving give VBG cord-018017-c8myq6bi 131 10 them -PRON- PRP cord-018017-c8myq6bi 131 11 a a DT cord-018017-c8myq6bi 131 12 chance chance NN cord-018017-c8myq6bi 131 13 to to TO cord-018017-c8myq6bi 131 14 catch catch VB cord-018017-c8myq6bi 131 15 up up RP cord-018017-c8myq6bi 131 16 to to IN cord-018017-c8myq6bi 131 17 the the DT cord-018017-c8myq6bi 131 18 rapidly rapidly RB cord-018017-c8myq6bi 131 19 proliferating proliferate VBG cord-018017-c8myq6bi 131 20 virus virus NN cord-018017-c8myq6bi 131 21 . . . cord-018017-c8myq6bi 132 1 The the DT cord-018017-c8myq6bi 132 2 Ebola Ebola NNP cord-018017-c8myq6bi 132 3 outbreak outbreak NN cord-018017-c8myq6bi 132 4 of of IN cord-018017-c8myq6bi 132 5 2014 2014 CD cord-018017-c8myq6bi 132 6 illuminated illuminate VBN cord-018017-c8myq6bi 132 7 the the DT cord-018017-c8myq6bi 132 8 collateral collateral JJ cord-018017-c8myq6bi 132 9 damage damage NN cord-018017-c8myq6bi 132 10 that that WDT cord-018017-c8myq6bi 132 11 accompanies accompany VBZ cord-018017-c8myq6bi 132 12 EID eid NN cord-018017-c8myq6bi 132 13 outbreaks outbreak NNS cord-018017-c8myq6bi 132 14 . . . cord-018017-c8myq6bi 133 1 First first RB cord-018017-c8myq6bi 133 2 , , , cord-018017-c8myq6bi 133 3 the the DT cord-018017-c8myq6bi 133 4 first first JJ cord-018017-c8myq6bi 133 5 responders responder NNS cord-018017-c8myq6bi 133 6 are be VBP cord-018017-c8myq6bi 133 7 local local JJ cord-018017-c8myq6bi 133 8 physicians physician NNS cord-018017-c8myq6bi 133 9 and and CC cord-018017-c8myq6bi 133 10 care care NN cord-018017-c8myq6bi 133 11 givers giver NNS cord-018017-c8myq6bi 133 12 are be VBP cord-018017-c8myq6bi 133 13 killed kill VBN cord-018017-c8myq6bi 133 14 leaving leave VBG cord-018017-c8myq6bi 133 15 a a DT cord-018017-c8myq6bi 133 16 population population NN cord-018017-c8myq6bi 133 17 lacking lack VBG cord-018017-c8myq6bi 133 18 doctors doctor NNS cord-018017-c8myq6bi 133 19 and and CC cord-018017-c8myq6bi 133 20 nurses nurse NNS cord-018017-c8myq6bi 133 21 . . . cord-018017-c8myq6bi 134 1 Even even RB cord-018017-c8myq6bi 134 2 physicians physician NNS cord-018017-c8myq6bi 134 3 trained train VBN cord-018017-c8myq6bi 134 4 to to TO cord-018017-c8myq6bi 134 5 exercise exercise VB cord-018017-c8myq6bi 134 6 appropriate appropriate JJ cord-018017-c8myq6bi 134 7 caution caution NN cord-018017-c8myq6bi 134 8 when when WRB cord-018017-c8myq6bi 134 9 interacting interact VBG cord-018017-c8myq6bi 134 10 with with IN cord-018017-c8myq6bi 134 11 patients patient NNS cord-018017-c8myq6bi 134 12 such such JJ cord-018017-c8myq6bi 134 13 as as IN cord-018017-c8myq6bi 134 14 Dr. Dr. NNP cord-018017-c8myq6bi 134 15 Sheik Sheik NNP cord-018017-c8myq6bi 134 16 Humarr Humarr NNP cord-018017-c8myq6bi 134 17 Khan Khan NNP cord-018017-c8myq6bi 135 1 died die VBD cord-018017-c8myq6bi 135 2 of of IN cord-018017-c8myq6bi 135 3 the the DT cord-018017-c8myq6bi 135 4 Ebola Ebola NNP cord-018017-c8myq6bi 135 5 infection infection NN cord-018017-c8myq6bi 135 6 ( ( -LRB- cord-018017-c8myq6bi 135 7 Bausch Bausch NNP cord-018017-c8myq6bi 135 8 et et NNP cord-018017-c8myq6bi 135 9 al al NNP cord-018017-c8myq6bi 135 10 . . NNP cord-018017-c8myq6bi 135 11 2014 2014 CD cord-018017-c8myq6bi 135 12 ) ) -RRB- cord-018017-c8myq6bi 135 13 . . . cord-018017-c8myq6bi 136 1 Second second RB cord-018017-c8myq6bi 136 2 , , , cord-018017-c8myq6bi 136 3 women woman NNS cord-018017-c8myq6bi 136 4 are be VBP cord-018017-c8myq6bi 136 5 the the DT cord-018017-c8myq6bi 136 6 main main JJ cord-018017-c8myq6bi 136 7 caregivers caregiver NNS cord-018017-c8myq6bi 136 8 in in IN cord-018017-c8myq6bi 136 9 their -PRON- PRP$ cord-018017-c8myq6bi 136 10 families family NNS cord-018017-c8myq6bi 136 11 and and CC cord-018017-c8myq6bi 136 12 75 75 CD cord-018017-c8myq6bi 136 13 percent percent NN cord-018017-c8myq6bi 136 14 of of IN cord-018017-c8myq6bi 136 15 Ebola Ebola NNP cord-018017-c8myq6bi 136 16 deaths death NNS cord-018017-c8myq6bi 136 17 in in IN cord-018017-c8myq6bi 136 18 the the DT cord-018017-c8myq6bi 136 19 2014 2014 CD cord-018017-c8myq6bi 136 20 outbreak outbreak NN cord-018017-c8myq6bi 136 21 were be VBD cord-018017-c8myq6bi 136 22 women woman NNS cord-018017-c8myq6bi 136 23 . . . cord-018017-c8myq6bi 137 1 This this DT cord-018017-c8myq6bi 137 2 leaves leave VBZ cord-018017-c8myq6bi 137 3 families family NNS cord-018017-c8myq6bi 137 4 lacking lack VBG cord-018017-c8myq6bi 137 5 traditional traditional JJ cord-018017-c8myq6bi 137 6 structure structure NN cord-018017-c8myq6bi 137 7 . . . cord-018017-c8myq6bi 138 1 Third third RB cord-018017-c8myq6bi 138 2 , , , cord-018017-c8myq6bi 138 3 the the DT cord-018017-c8myq6bi 138 4 outbreak outbreak NN cord-018017-c8myq6bi 138 5 disrupts disrupt VBZ cord-018017-c8myq6bi 138 6 production production NN cord-018017-c8myq6bi 138 7 , , , cord-018017-c8myq6bi 138 8 labor labor NN cord-018017-c8myq6bi 138 9 markets market NNS cord-018017-c8myq6bi 138 10 and and CC cord-018017-c8myq6bi 138 11 trade trade NN cord-018017-c8myq6bi 138 12 resulting result VBG cord-018017-c8myq6bi 138 13 in in IN cord-018017-c8myq6bi 138 14 scarcity scarcity NN cord-018017-c8myq6bi 138 15 and and CC cord-018017-c8myq6bi 138 16 inflation inflation NN cord-018017-c8myq6bi 138 17 of of IN cord-018017-c8myq6bi 138 18 food food NN cord-018017-c8myq6bi 138 19 prices price NNS cord-018017-c8myq6bi 138 20 . . . cord-018017-c8myq6bi 139 1 Food food NN cord-018017-c8myq6bi 139 2 security security NN cord-018017-c8myq6bi 139 3 and and CC cord-018017-c8myq6bi 139 4 nutrition nutrition NN cord-018017-c8myq6bi 139 5 are be VBP cord-018017-c8myq6bi 139 6 diminished diminish VBN cord-018017-c8myq6bi 139 7 which which WDT cord-018017-c8myq6bi 139 8 preferentially preferentially RB cord-018017-c8myq6bi 139 9 affects affect VBZ cord-018017-c8myq6bi 139 10 poor poor JJ cord-018017-c8myq6bi 139 11 people people NNS cord-018017-c8myq6bi 139 12 as as IN cord-018017-c8myq6bi 139 13 they -PRON- PRP cord-018017-c8myq6bi 139 14 spend spend VBP cord-018017-c8myq6bi 139 15 50 50 CD cord-018017-c8myq6bi 139 16 to to TO cord-018017-c8myq6bi 139 17 70 70 CD cord-018017-c8myq6bi 139 18 % % NN cord-018017-c8myq6bi 139 19 of of IN cord-018017-c8myq6bi 139 20 their -PRON- PRP$ cord-018017-c8myq6bi 139 21 income income NN cord-018017-c8myq6bi 139 22 on on IN cord-018017-c8myq6bi 139 23 food food NN cord-018017-c8myq6bi 139 24 . . . cord-018017-c8myq6bi 140 1 Finally finally RB cord-018017-c8myq6bi 140 2 , , , cord-018017-c8myq6bi 140 3 public public JJ cord-018017-c8myq6bi 140 4 health health NN cord-018017-c8myq6bi 140 5 measures measure NNS cord-018017-c8myq6bi 140 6 are be VBP cord-018017-c8myq6bi 140 7 discontinued discontinue VBN cord-018017-c8myq6bi 140 8 . . . cord-018017-c8myq6bi 141 1 Before before IN cord-018017-c8myq6bi 141 2 the the DT cord-018017-c8myq6bi 141 3 2014 2014 CD cord-018017-c8myq6bi 141 4 outbreak outbreak NN cord-018017-c8myq6bi 141 5 , , , cord-018017-c8myq6bi 141 6 97 97 CD cord-018017-c8myq6bi 141 7 percent percent NN cord-018017-c8myq6bi 141 8 of of IN cord-018017-c8myq6bi 141 9 children child NNS cord-018017-c8myq6bi 141 10 in in IN cord-018017-c8myq6bi 141 11 West West NNP cord-018017-c8myq6bi 141 12 Africa Africa NNP cord-018017-c8myq6bi 141 13 were be VBD cord-018017-c8myq6bi 141 14 receiving receive VBG cord-018017-c8myq6bi 141 15 routine routine JJ cord-018017-c8myq6bi 141 16 vaccinations vaccination NNS cord-018017-c8myq6bi 141 17 but but CC cord-018017-c8myq6bi 141 18 that that DT cord-018017-c8myq6bi 141 19 figure figure NN cord-018017-c8myq6bi 141 20 fell fall VBD cord-018017-c8myq6bi 141 21 below below IN cord-018017-c8myq6bi 141 22 27 27 CD cord-018017-c8myq6bi 141 23 percent percent NN cord-018017-c8myq6bi 141 24 . . . cord-018017-c8myq6bi 142 1 The the DT cord-018017-c8myq6bi 142 2 West West NNP cord-018017-c8myq6bi 142 3 Africa Africa NNP cord-018017-c8myq6bi 142 4 loss loss NN cord-018017-c8myq6bi 142 5 of of IN cord-018017-c8myq6bi 142 6 measles measles NN cord-018017-c8myq6bi 142 7 vaccinations vaccination NNS cord-018017-c8myq6bi 142 8 was be VBD cord-018017-c8myq6bi 142 9 followed follow VBN cord-018017-c8myq6bi 142 10 by by IN cord-018017-c8myq6bi 142 11 measles measle NNS cord-018017-c8myq6bi 142 12 out- out- XX cord-018017-c8myq6bi 142 13 _SP cord-018017-c8myq6bi 143 1 Coronaviruses coronaviruse NNS cord-018017-c8myq6bi 143 2 are be VBP cord-018017-c8myq6bi 143 3 unique unique JJ cord-018017-c8myq6bi 143 4 in in IN cord-018017-c8myq6bi 143 5 their -PRON- PRP$ cord-018017-c8myq6bi 143 6 large large JJ cord-018017-c8myq6bi 143 7 single single JJ cord-018017-c8myq6bi 143 8 - - HYPH cord-018017-c8myq6bi 143 9 stranded strand VBN cord-018017-c8myq6bi 143 10 RNA RNA NNP cord-018017-c8myq6bi 143 11 genome genome NN cord-018017-c8myq6bi 143 12 ( ( -LRB- cord-018017-c8myq6bi 143 13 20,000 20,000 CD cord-018017-c8myq6bi 143 14 bases basis NNS cord-018017-c8myq6bi 143 15 ) ) -RRB- cord-018017-c8myq6bi 143 16 and and CC cord-018017-c8myq6bi 143 17 are be VBP cord-018017-c8myq6bi 143 18 often often RB cord-018017-c8myq6bi 143 19 associated associate VBN cord-018017-c8myq6bi 143 20 with with IN cord-018017-c8myq6bi 143 21 mild mild JJ cord-018017-c8myq6bi 143 22 disease disease NN cord-018017-c8myq6bi 143 23 , , , cord-018017-c8myq6bi 143 24 bronchitis bronchitis NN cord-018017-c8myq6bi 143 25 and and CC cord-018017-c8myq6bi 143 26 gastroenteritis gastroenteritis NN cord-018017-c8myq6bi 143 27 . . . cord-018017-c8myq6bi 144 1 A a DT cord-018017-c8myq6bi 144 2 2003 2003 CD cord-018017-c8myq6bi 144 3 outbreak outbreak NN cord-018017-c8myq6bi 144 4 of of IN cord-018017-c8myq6bi 144 5 Severe severe JJ cord-018017-c8myq6bi 144 6 Acute acute JJ cord-018017-c8myq6bi 144 7 Respiratory Respiratory NNP cord-018017-c8myq6bi 144 8 Syndrome Syndrome NNP cord-018017-c8myq6bi 144 9 coronavirus coronavirus NN cord-018017-c8myq6bi 144 10 ( ( -LRB- cord-018017-c8myq6bi 144 11 SARS SARS NNP cord-018017-c8myq6bi 144 12 - - HYPH cord-018017-c8myq6bi 144 13 CoV CoV NNP cord-018017-c8myq6bi 144 14 ) ) -RRB- cord-018017-c8myq6bi 144 15 in in IN cord-018017-c8myq6bi 144 16 China China NNP cord-018017-c8myq6bi 144 17 rapidly rapidly RB cord-018017-c8myq6bi 144 18 spread spread VBD cord-018017-c8myq6bi 144 19 to to IN cord-018017-c8myq6bi 144 20 8098 8098 CD cord-018017-c8myq6bi 144 21 cases case NNS cord-018017-c8myq6bi 144 22 in in IN cord-018017-c8myq6bi 144 23 37 37 CD cord-018017-c8myq6bi 144 24 countries country NNS cord-018017-c8myq6bi 144 25 ( ( -LRB- cord-018017-c8myq6bi 144 26 Table table NN cord-018017-c8myq6bi 144 27 3 3 CD cord-018017-c8myq6bi 144 28 .4 .4 NFP cord-018017-c8myq6bi 144 29 ) ) -RRB- cord-018017-c8myq6bi 144 30 . . . cord-018017-c8myq6bi 145 1 Retrospective retrospective JJ cord-018017-c8myq6bi 145 2 analysis analysis NN cord-018017-c8myq6bi 145 3 of of IN cord-018017-c8myq6bi 145 4 this this DT cord-018017-c8myq6bi 145 5 outbreak outbreak NN cord-018017-c8myq6bi 145 6 linked link VBD cord-018017-c8myq6bi 145 7 zoonosis zoonosis NN cord-018017-c8myq6bi 145 8 to to IN cord-018017-c8myq6bi 145 9 a a DT cord-018017-c8myq6bi 145 10 culinary culinary JJ cord-018017-c8myq6bi 145 11 trend trend NN cord-018017-c8myq6bi 145 12 in in IN cord-018017-c8myq6bi 145 13 which which WDT cord-018017-c8myq6bi 145 14 people people NNS cord-018017-c8myq6bi 145 15 sought seek VBD cord-018017-c8myq6bi 145 16 out out RP cord-018017-c8myq6bi 145 17 exotic exotic JJ cord-018017-c8myq6bi 145 18 animals animal NNS cord-018017-c8myq6bi 145 19 to to TO cord-018017-c8myq6bi 145 20 eat eat VB cord-018017-c8myq6bi 145 21 . . . cord-018017-c8myq6bi 146 1 These these DT cord-018017-c8myq6bi 146 2 nontraditional nontraditional JJ cord-018017-c8myq6bi 146 3 food food NN cord-018017-c8myq6bi 146 4 animals animal NNS cord-018017-c8myq6bi 146 5 appeared appear VBD cord-018017-c8myq6bi 146 6 in in IN cord-018017-c8myq6bi 146 7 street street NN cord-018017-c8myq6bi 146 8 markets market NNS cord-018017-c8myq6bi 146 9 in in IN cord-018017-c8myq6bi 146 10 urban urban JJ cord-018017-c8myq6bi 146 11 areas area NNS cord-018017-c8myq6bi 146 12 bringing bring VBG cord-018017-c8myq6bi 146 13 people people NNS cord-018017-c8myq6bi 146 14 close close JJ cord-018017-c8myq6bi 146 15 to to IN cord-018017-c8myq6bi 146 16 the the DT cord-018017-c8myq6bi 146 17 reservoir reservoir NN cord-018017-c8myq6bi 146 18 host host NN cord-018017-c8myq6bi 146 19 triggering trigger VBG cord-018017-c8myq6bi 146 20 the the DT cord-018017-c8myq6bi 146 21 outbreak outbreak NN cord-018017-c8myq6bi 146 22 . . . cord-018017-c8myq6bi 147 1 The the DT cord-018017-c8myq6bi 147 2 civet civet NN cord-018017-c8myq6bi 147 3 cat cat NN cord-018017-c8myq6bi 147 4 was be VBD cord-018017-c8myq6bi 147 5 identified identify VBN cord-018017-c8myq6bi 147 6 as as IN cord-018017-c8myq6bi 147 7 the the DT cord-018017-c8myq6bi 147 8 source source NN cord-018017-c8myq6bi 147 9 of of IN cord-018017-c8myq6bi 147 10 the the DT cord-018017-c8myq6bi 147 11 first first JJ cord-018017-c8myq6bi 147 12 human human JJ cord-018017-c8myq6bi 147 13 cases case NNS cord-018017-c8myq6bi 147 14 but but CC cord-018017-c8myq6bi 147 15 this this DT cord-018017-c8myq6bi 147 16 is be VBZ cord-018017-c8myq6bi 147 17 not not RB cord-018017-c8myq6bi 147 18 the the DT cord-018017-c8myq6bi 147 19 natural natural JJ cord-018017-c8myq6bi 147 20 host host NN cord-018017-c8myq6bi 147 21 . . . cord-018017-c8myq6bi 148 1 The the DT cord-018017-c8myq6bi 148 2 natural natural JJ cord-018017-c8myq6bi 148 3 host host NN cord-018017-c8myq6bi 148 4 is be VBZ cord-018017-c8myq6bi 148 5 the the DT cord-018017-c8myq6bi 148 6 fruit fruit NN cord-018017-c8myq6bi 148 7 bat bat NN cord-018017-c8myq6bi 148 8 , , , cord-018017-c8myq6bi 148 9 which which WDT cord-018017-c8myq6bi 148 10 infects infect VBZ cord-018017-c8myq6bi 148 11 a a DT cord-018017-c8myq6bi 148 12 variety variety NN cord-018017-c8myq6bi 148 13 of of IN cord-018017-c8myq6bi 148 14 small small JJ cord-018017-c8myq6bi 148 15 mammals mammal NNS cord-018017-c8myq6bi 148 16 including include VBG cord-018017-c8myq6bi 148 17 the the DT cord-018017-c8myq6bi 148 18 civet civet NN cord-018017-c8myq6bi 148 19 cat cat NN cord-018017-c8myq6bi 148 20 . . . cord-018017-c8myq6bi 149 1 A a DT cord-018017-c8myq6bi 149 2 point point NN cord-018017-c8myq6bi 149 3 of of IN cord-018017-c8myq6bi 149 4 intervention intervention NN cord-018017-c8myq6bi 149 5 has have VBZ cord-018017-c8myq6bi 149 6 been be VBN cord-018017-c8myq6bi 149 7 removal removal NN cord-018017-c8myq6bi 149 8 of of IN cord-018017-c8myq6bi 149 9 the the DT cord-018017-c8myq6bi 149 10 civet civet NN cord-018017-c8myq6bi 149 11 cat cat NN cord-018017-c8myq6bi 149 12 from from IN cord-018017-c8myq6bi 149 13 markets market NNS cord-018017-c8myq6bi 149 14 but but CC cord-018017-c8myq6bi 149 15 the the DT cord-018017-c8myq6bi 149 16 natural natural JJ cord-018017-c8myq6bi 149 17 bat bat NN cord-018017-c8myq6bi 149 18 host host NN cord-018017-c8myq6bi 149 19 remains remain VBZ cord-018017-c8myq6bi 149 20 in in IN cord-018017-c8myq6bi 149 21 the the DT cord-018017-c8myq6bi 149 22 environment environment NN cord-018017-c8myq6bi 149 23 maintaining maintain VBG cord-018017-c8myq6bi 149 24 the the DT cord-018017-c8myq6bi 149 25 virus virus NN cord-018017-c8myq6bi 149 26 for for IN cord-018017-c8myq6bi 149 27 the the DT cord-018017-c8myq6bi 149 28 next next JJ cord-018017-c8myq6bi 149 29 outbreak outbreak NN cord-018017-c8myq6bi 149 30 . . . cord-018017-c8myq6bi 150 1 A a DT cord-018017-c8myq6bi 150 2 second second JJ cord-018017-c8myq6bi 150 3 coronavirus coronavirus NN cord-018017-c8myq6bi 150 4 outbreak outbreak NN cord-018017-c8myq6bi 150 5 in in IN cord-018017-c8myq6bi 150 6 2014 2014 CD cord-018017-c8myq6bi 150 7 of of IN cord-018017-c8myq6bi 150 8 Middle Middle NNP cord-018017-c8myq6bi 150 9 East East NNP cord-018017-c8myq6bi 150 10 Respiratory Respiratory NNP cord-018017-c8myq6bi 150 11 Syndrome Syndrome NNP cord-018017-c8myq6bi 150 12 coronavirus coronavirus NN cord-018017-c8myq6bi 150 13 ( ( -LRB- cord-018017-c8myq6bi 150 14 MERS MERS NNP cord-018017-c8myq6bi 150 15 CoV CoV NNP cord-018017-c8myq6bi 150 16 ) ) -RRB- cord-018017-c8myq6bi 150 17 rapidly rapidly RB cord-018017-c8myq6bi 150 18 involved involve VBD cord-018017-c8myq6bi 150 19 23 23 CD cord-018017-c8myq6bi 150 20 countries country NNS cord-018017-c8myq6bi 150 21 including include VBG cord-018017-c8myq6bi 150 22 Africa Africa NNP cord-018017-c8myq6bi 150 23 , , , cord-018017-c8myq6bi 150 24 Western Western NNP cord-018017-c8myq6bi 150 25 Europe Europe NNP cord-018017-c8myq6bi 150 26 , , , cord-018017-c8myq6bi 150 27 and and CC cord-018017-c8myq6bi 150 28 Southeast Southeast NNP cord-018017-c8myq6bi 150 29 Asia Asia NNP cord-018017-c8myq6bi 150 30 . . . cord-018017-c8myq6bi 151 1 The the DT cord-018017-c8myq6bi 151 2 number number NN cord-018017-c8myq6bi 151 3 of of IN cord-018017-c8myq6bi 151 4 cases case NNS cord-018017-c8myq6bi 151 5 is be VBZ cord-018017-c8myq6bi 151 6 relatively relatively RB cord-018017-c8myq6bi 151 7 low low JJ cord-018017-c8myq6bi 151 8 but but CC cord-018017-c8myq6bi 151 9 the the DT cord-018017-c8myq6bi 151 10 case case NN cord-018017-c8myq6bi 151 11 fatality fatality NN cord-018017-c8myq6bi 151 12 ratio ratio NN cord-018017-c8myq6bi 151 13 is be VBZ cord-018017-c8myq6bi 151 14 of of IN cord-018017-c8myq6bi 151 15 great great JJ cord-018017-c8myq6bi 151 16 concern concern NN cord-018017-c8myq6bi 151 17 ( ( -LRB- cord-018017-c8myq6bi 151 18 Table Table NNP cord-018017-c8myq6bi 151 19 3.4 3.4 CD cord-018017-c8myq6bi 151 20 ) ) -RRB- cord-018017-c8myq6bi 151 21 . . . cord-018017-c8myq6bi 152 1 The the DT cord-018017-c8myq6bi 152 2 camel camel NN cord-018017-c8myq6bi 152 3 is be VBZ cord-018017-c8myq6bi 152 4 reservoir reservoir NN cord-018017-c8myq6bi 152 5 host host NN cord-018017-c8myq6bi 152 6 in in IN cord-018017-c8myq6bi 152 7 this this DT cord-018017-c8myq6bi 152 8 case case NN cord-018017-c8myq6bi 152 9 but but CC cord-018017-c8myq6bi 152 10 it -PRON- PRP cord-018017-c8myq6bi 152 11 may may MD cord-018017-c8myq6bi 152 12 not not RB cord-018017-c8myq6bi 152 13 be be VB cord-018017-c8myq6bi 152 14 the the DT cord-018017-c8myq6bi 152 15 natural natural JJ cord-018017-c8myq6bi 152 16 host host NN cord-018017-c8myq6bi 152 17 since since IN cord-018017-c8myq6bi 152 18 camels camel NNS cord-018017-c8myq6bi 152 19 often often RB cord-018017-c8myq6bi 152 20 get get VBP cord-018017-c8myq6bi 152 21 sick sick JJ cord-018017-c8myq6bi 152 22 as as RB cord-018017-c8myq6bi 152 23 well well RB cord-018017-c8myq6bi 152 24 . . . cord-018017-c8myq6bi 153 1 Transition transition NN cord-018017-c8myq6bi 153 2 from from IN cord-018017-c8myq6bi 153 3 animal animal NN cord-018017-c8myq6bi 153 4 - - HYPH cord-018017-c8myq6bi 153 5 to to IN cord-018017-c8myq6bi 153 6 - - HYPH cord-018017-c8myq6bi 153 7 human human JJ cord-018017-c8myq6bi 153 8 transmission transmission NN cord-018017-c8myq6bi 153 9 to to IN cord-018017-c8myq6bi 153 10 efficient efficient JJ cord-018017-c8myq6bi 153 11 human human NN cord-018017-c8myq6bi 153 12 - - HYPH cord-018017-c8myq6bi 153 13 to to IN cord-018017-c8myq6bi 153 14 - - HYPH cord-018017-c8myq6bi 153 15 human human JJ cord-018017-c8myq6bi 153 16 transmission transmission NN cord-018017-c8myq6bi 153 17 was be VBD cord-018017-c8myq6bi 153 18 observed observe VBN cord-018017-c8myq6bi 153 19 quickly quickly RB cord-018017-c8myq6bi 153 20 in in IN cord-018017-c8myq6bi 153 21 the the DT cord-018017-c8myq6bi 153 22 case case NN cord-018017-c8myq6bi 153 23 of of IN cord-018017-c8myq6bi 153 24 both both DT cord-018017-c8myq6bi 153 25 SARS SARS NNP cord-018017-c8myq6bi 153 26 - - HYPH cord-018017-c8myq6bi 153 27 CoV CoV NNP cord-018017-c8myq6bi 153 28 and and CC cord-018017-c8myq6bi 153 29 MERS MERS NNP cord-018017-c8myq6bi 153 30 - - HYPH cord-018017-c8myq6bi 153 31 CoV. CoV. NNP cord-018017-c8myq6bi 154 1 This this DT cord-018017-c8myq6bi 154 2 rapid rapid JJ cord-018017-c8myq6bi 154 3 adaptability adaptability NN cord-018017-c8myq6bi 154 4 of of IN cord-018017-c8myq6bi 154 5 a a DT cord-018017-c8myq6bi 154 6 highly highly RB cord-018017-c8myq6bi 154 7 infectious infectious JJ cord-018017-c8myq6bi 154 8 virus virus NN cord-018017-c8myq6bi 154 9 group group NN cord-018017-c8myq6bi 154 10 should should MD cord-018017-c8myq6bi 154 11 raise raise VB cord-018017-c8myq6bi 154 12 concern concern NN cord-018017-c8myq6bi 154 13 over over IN cord-018017-c8myq6bi 154 14 endemic endemic JJ cord-018017-c8myq6bi 154 15 coronaviruses coronaviruse NNS cord-018017-c8myq6bi 154 16 in in IN cord-018017-c8myq6bi 154 17 companion companion NN cord-018017-c8myq6bi 154 18 animals animal NNS cord-018017-c8myq6bi 154 19 since since IN cord-018017-c8myq6bi 154 20 these these DT cord-018017-c8myq6bi 154 21 viruses virus NNS cord-018017-c8myq6bi 154 22 can can MD cord-018017-c8myq6bi 154 23 clearly clearly RB cord-018017-c8myq6bi 154 24 become become VB cord-018017-c8myq6bi 154 25 pathogenic pathogenic JJ cord-018017-c8myq6bi 154 26 , , , cord-018017-c8myq6bi 154 27 can can MD cord-018017-c8myq6bi 154 28 jump jump VB cord-018017-c8myq6bi 154 29 from from IN cord-018017-c8myq6bi 154 30 animal animal NN cord-018017-c8myq6bi 154 31 to to IN cord-018017-c8myq6bi 154 32 human human NN cord-018017-c8myq6bi 154 33 and and CC cord-018017-c8myq6bi 154 34 then then RB cord-018017-c8myq6bi 154 35 become become VB cord-018017-c8myq6bi 154 36 transmitted transmit VBN cord-018017-c8myq6bi 154 37 from from IN cord-018017-c8myq6bi 154 38 human human NN cord-018017-c8myq6bi 154 39 - - HYPH cord-018017-c8myq6bi 154 40 to to IN cord-018017-c8myq6bi 154 41 - - HYPH cord-018017-c8myq6bi 154 42 human human NN cord-018017-c8myq6bi 154 43 . . . cord-018017-c8myq6bi 155 1 An an DT cord-018017-c8myq6bi 155 2 ongoing ongoing JJ cord-018017-c8myq6bi 155 3 outbreak outbreak NN cord-018017-c8myq6bi 155 4 of of IN cord-018017-c8myq6bi 155 5 Yellow Yellow NNP cord-018017-c8myq6bi 155 6 Fever Fever NNP cord-018017-c8myq6bi 155 7 in in IN cord-018017-c8myq6bi 155 8 Africa Africa NNP cord-018017-c8myq6bi 155 9 ( ( -LRB- cord-018017-c8myq6bi 155 10 Table table NN cord-018017-c8myq6bi 155 11 3 3 CD cord-018017-c8myq6bi 155 12 .4 .4 NFP cord-018017-c8myq6bi 155 13 ) ) -RRB- cord-018017-c8myq6bi 155 14 is be VBZ cord-018017-c8myq6bi 155 15 a a DT cord-018017-c8myq6bi 155 16 striking striking JJ cord-018017-c8myq6bi 155 17 reminder reminder NN cord-018017-c8myq6bi 155 18 that that IN cord-018017-c8myq6bi 155 19 EID EID NNP cord-018017-c8myq6bi 155 20 can can MD cord-018017-c8myq6bi 155 21 re re VB cord-018017-c8myq6bi 155 22 - - VB cord-018017-c8myq6bi 155 23 emerge emerge VB cord-018017-c8myq6bi 155 24 into into IN cord-018017-c8myq6bi 155 25 virtually virtually RB cord-018017-c8myq6bi 155 26 naïve naïve JJ cord-018017-c8myq6bi 155 27 populations population NNS cord-018017-c8myq6bi 155 28 . . . cord-018017-c8myq6bi 156 1 Some some DT cord-018017-c8myq6bi 156 2 people people NNS cord-018017-c8myq6bi 156 3 recover recover VBP cord-018017-c8myq6bi 156 4 from from IN cord-018017-c8myq6bi 156 5 the the DT cord-018017-c8myq6bi 156 6 acute acute JJ cord-018017-c8myq6bi 156 7 symptoms symptom NNS cord-018017-c8myq6bi 156 8 but but CC cord-018017-c8myq6bi 156 9 liver liver NN cord-018017-c8myq6bi 156 10 damage damage NN cord-018017-c8myq6bi 156 11 causes cause VBZ cord-018017-c8myq6bi 156 12 yellow yellow JJ cord-018017-c8myq6bi 156 13 skin skin NN cord-018017-c8myq6bi 156 14 , , , cord-018017-c8myq6bi 156 15 the the DT cord-018017-c8myq6bi 156 16 reason reason NN cord-018017-c8myq6bi 156 17 for for IN cord-018017-c8myq6bi 156 18 the the DT cord-018017-c8myq6bi 156 19 name name NN cord-018017-c8myq6bi 156 20 for for IN cord-018017-c8myq6bi 156 21 the the DT cord-018017-c8myq6bi 156 22 disease disease NN cord-018017-c8myq6bi 156 23 . . . cord-018017-c8myq6bi 157 1 The the DT cord-018017-c8myq6bi 157 2 liver liver NN cord-018017-c8myq6bi 157 3 damage damage NN cord-018017-c8myq6bi 157 4 leads lead VBZ cord-018017-c8myq6bi 157 5 to to IN cord-018017-c8myq6bi 157 6 bleeding bleeding NN cord-018017-c8myq6bi 157 7 and and CC cord-018017-c8myq6bi 157 8 kidney kidney NN cord-018017-c8myq6bi 157 9 damage damage NN cord-018017-c8myq6bi 157 10 and and CC cord-018017-c8myq6bi 157 11 occasionally occasionally RB cord-018017-c8myq6bi 157 12 death death NN cord-018017-c8myq6bi 157 13 . . . cord-018017-c8myq6bi 158 1 Yellow Yellow NNP cord-018017-c8myq6bi 158 2 Fever Fever NNP cord-018017-c8myq6bi 158 3 is be VBZ cord-018017-c8myq6bi 158 4 a a DT cord-018017-c8myq6bi 158 5 flavivirus flavivirus NN cord-018017-c8myq6bi 158 6 that that WDT cord-018017-c8myq6bi 158 7 originated originate VBD cord-018017-c8myq6bi 158 8 in in IN cord-018017-c8myq6bi 158 9 Africa Africa NNP cord-018017-c8myq6bi 158 10 but but CC cord-018017-c8myq6bi 158 11 was be VBD cord-018017-c8myq6bi 158 12 distributed distribute VBN cord-018017-c8myq6bi 158 13 to to IN cord-018017-c8myq6bi 158 14 the the DT cord-018017-c8myq6bi 158 15 world world NN cord-018017-c8myq6bi 158 16 on on IN cord-018017-c8myq6bi 158 17 barges barge NNS cord-018017-c8myq6bi 158 18 and and CC cord-018017-c8myq6bi 158 19 sailing sailing NN cord-018017-c8myq6bi 158 20 ships ship NNS cord-018017-c8myq6bi 158 21 to to IN cord-018017-c8myq6bi 158 22 tropical tropical JJ cord-018017-c8myq6bi 158 23 ports port NNS cord-018017-c8myq6bi 158 24 . . . cord-018017-c8myq6bi 159 1 The the DT cord-018017-c8myq6bi 159 2 virus virus NN cord-018017-c8myq6bi 159 3 arrived arrive VBD cord-018017-c8myq6bi 159 4 in in IN cord-018017-c8myq6bi 159 5 the the DT cord-018017-c8myq6bi 159 6 Americas Americas NNPS cord-018017-c8myq6bi 159 7 on on IN cord-018017-c8myq6bi 159 8 slave slave NN cord-018017-c8myq6bi 159 9 ships ship NNS cord-018017-c8myq6bi 159 10 . . . cord-018017-c8myq6bi 160 1 This this DT cord-018017-c8myq6bi 160 2 virus virus NN cord-018017-c8myq6bi 160 3 interrupted interrupt VBD cord-018017-c8myq6bi 160 4 the the DT cord-018017-c8myq6bi 160 5 building building NN cord-018017-c8myq6bi 160 6 of of IN cord-018017-c8myq6bi 160 7 the the DT cord-018017-c8myq6bi 160 8 Panama Panama NNP cord-018017-c8myq6bi 160 9 Canal Canal NNP cord-018017-c8myq6bi 160 10 which which WDT cord-018017-c8myq6bi 160 11 attracted attract VBD cord-018017-c8myq6bi 160 12 the the DT cord-018017-c8myq6bi 160 13 attention attention NN cord-018017-c8myq6bi 160 14 of of IN cord-018017-c8myq6bi 160 15 Walter Walter NNP cord-018017-c8myq6bi 160 16 Reed Reed NNP cord-018017-c8myq6bi 160 17 , , , cord-018017-c8myq6bi 160 18 the the DT cord-018017-c8myq6bi 160 19 military military JJ cord-018017-c8myq6bi 160 20 physician physician NN cord-018017-c8myq6bi 160 21 responsible responsible JJ cord-018017-c8myq6bi 160 22 for for IN cord-018017-c8myq6bi 160 23 demonstrating demonstrate VBG cord-018017-c8myq6bi 160 24 transmission transmission NN cord-018017-c8myq6bi 160 25 by by IN cord-018017-c8myq6bi 160 26 mosquitos mosquito NNS cord-018017-c8myq6bi 160 27 . . . cord-018017-c8myq6bi 161 1 An an DT cord-018017-c8myq6bi 161 2 effective effective JJ cord-018017-c8myq6bi 161 3 vaccine vaccine NN cord-018017-c8myq6bi 161 4 is be VBZ cord-018017-c8myq6bi 161 5 used use VBN cord-018017-c8myq6bi 161 6 worldwide worldwide RB cord-018017-c8myq6bi 161 7 with with IN cord-018017-c8myq6bi 161 8 immunity immunity NN cord-018017-c8myq6bi 161 9 lasting last VBG cord-018017-c8myq6bi 161 10 over over IN cord-018017-c8myq6bi 161 11 10 10 CD cord-018017-c8myq6bi 161 12 years year NNS cord-018017-c8myq6bi 161 13 . . . cord-018017-c8myq6bi 162 1 The the DT cord-018017-c8myq6bi 162 2 limitation limitation NN cord-018017-c8myq6bi 162 3 of of IN cord-018017-c8myq6bi 162 4 this this DT cord-018017-c8myq6bi 162 5 vaccine vaccine NN cord-018017-c8myq6bi 162 6 like like IN cord-018017-c8myq6bi 162 7 most most RBS cord-018017-c8myq6bi 162 8 is be VBZ cord-018017-c8myq6bi 162 9 that that IN cord-018017-c8myq6bi 162 10 populations population NNS cord-018017-c8myq6bi 162 11 need need VBP cord-018017-c8myq6bi 162 12 to to TO cord-018017-c8myq6bi 162 13 be be VB cord-018017-c8myq6bi 162 14 vaccinated vaccinate VBN cord-018017-c8myq6bi 162 15 regularly regularly RB cord-018017-c8myq6bi 162 16 which which WDT cord-018017-c8myq6bi 162 17 in in IN cord-018017-c8myq6bi 162 18 a a DT cord-018017-c8myq6bi 162 19 world world NN cord-018017-c8myq6bi 162 20 constantly constantly RB cord-018017-c8myq6bi 162 21 changing change VBG cord-018017-c8myq6bi 162 22 due due IN cord-018017-c8myq6bi 162 23 to to IN cord-018017-c8myq6bi 162 24 political political JJ cord-018017-c8myq6bi 162 25 and and CC cord-018017-c8myq6bi 162 26 economic economic JJ cord-018017-c8myq6bi 162 27 drivers driver NNS cord-018017-c8myq6bi 162 28 leads lead VBZ cord-018017-c8myq6bi 162 29 to to IN cord-018017-c8myq6bi 162 30 vaccination vaccination NN cord-018017-c8myq6bi 162 31 gaps gap NNS cord-018017-c8myq6bi 162 32 . . . cord-018017-c8myq6bi 163 1 Cancer cancer NN cord-018017-c8myq6bi 163 2 is be VBZ cord-018017-c8myq6bi 163 3 one one CD cord-018017-c8myq6bi 163 4 of of IN cord-018017-c8myq6bi 163 5 the the DT cord-018017-c8myq6bi 163 6 leading lead VBG cord-018017-c8myq6bi 163 7 causes cause NNS cord-018017-c8myq6bi 163 8 of of IN cord-018017-c8myq6bi 163 9 human human JJ cord-018017-c8myq6bi 163 10 death death NN cord-018017-c8myq6bi 163 11 but but CC cord-018017-c8myq6bi 163 12 estimates estimate NNS cord-018017-c8myq6bi 163 13 are be VBP cord-018017-c8myq6bi 163 14 that that IN cord-018017-c8myq6bi 163 15 20 20 CD cord-018017-c8myq6bi 163 16 percent percent NN cord-018017-c8myq6bi 163 17 of of IN cord-018017-c8myq6bi 163 18 all all DT cord-018017-c8myq6bi 163 19 human human JJ cord-018017-c8myq6bi 163 20 cancers cancer NNS cord-018017-c8myq6bi 163 21 are be VBP cord-018017-c8myq6bi 163 22 directly directly RB cord-018017-c8myq6bi 163 23 caused cause VBN cord-018017-c8myq6bi 163 24 by by IN cord-018017-c8myq6bi 163 25 viruses virus NNS cord-018017-c8myq6bi 163 26 ( ( -LRB- cord-018017-c8myq6bi 163 27 Table table NN cord-018017-c8myq6bi 163 28 3 3 CD cord-018017-c8myq6bi 163 29 .5 .5 CD cord-018017-c8myq6bi 163 30 ) ) -RRB- cord-018017-c8myq6bi 164 1 ( ( -LRB- cord-018017-c8myq6bi 164 2 Morales Morales NNP cord-018017-c8myq6bi 164 3 - - HYPH cord-018017-c8myq6bi 164 4 Sanchez Sanchez NNP cord-018017-c8myq6bi 164 5 and and CC cord-018017-c8myq6bi 164 6 Fuentes Fuentes NNPS cord-018017-c8myq6bi 164 7 - - HYPH cord-018017-c8myq6bi 164 8 Panana Panana NNP cord-018017-c8myq6bi 164 9 2014 2014 CD cord-018017-c8myq6bi 164 10 ) ) -RRB- cord-018017-c8myq6bi 164 11 . . . cord-018017-c8myq6bi 165 1 The the DT cord-018017-c8myq6bi 165 2 first first JJ cord-018017-c8myq6bi 165 3 tumor tumor NN cord-018017-c8myq6bi 165 4 virus virus NN cord-018017-c8myq6bi 165 5 was be VBD cord-018017-c8myq6bi 165 6 identified identify VBN cord-018017-c8myq6bi 165 7 by by IN cord-018017-c8myq6bi 165 8 Peyton Peyton NNP cord-018017-c8myq6bi 165 9 Rous Rous NNP cord-018017-c8myq6bi 165 10 in in IN cord-018017-c8myq6bi 165 11 1911 1911 CD cord-018017-c8myq6bi 165 12 . . . cord-018017-c8myq6bi 166 1 He -PRON- PRP cord-018017-c8myq6bi 166 2 took take VBD cord-018017-c8myq6bi 166 3 cell cell NN cord-018017-c8myq6bi 166 4 lysates lysate NNS cord-018017-c8myq6bi 166 5 from from IN cord-018017-c8myq6bi 166 6 a a DT cord-018017-c8myq6bi 166 7 chicken chicken NN cord-018017-c8myq6bi 166 8 sarcoma sarcoma NN cord-018017-c8myq6bi 166 9 which which WDT cord-018017-c8myq6bi 166 10 he -PRON- PRP cord-018017-c8myq6bi 166 11 passed pass VBD cord-018017-c8myq6bi 166 12 through through IN cord-018017-c8myq6bi 166 13 a a DT cord-018017-c8myq6bi 166 14 filter filter NN cord-018017-c8myq6bi 166 15 known know VBN cord-018017-c8myq6bi 166 16 to to TO cord-018017-c8myq6bi 166 17 hold hold VB cord-018017-c8myq6bi 166 18 back back RP cord-018017-c8myq6bi 166 19 bacteria bacteria NNS cord-018017-c8myq6bi 166 20 and and CC cord-018017-c8myq6bi 166 21 then then RB cord-018017-c8myq6bi 166 22 injected inject VBD cord-018017-c8myq6bi 166 23 the the DT cord-018017-c8myq6bi 166 24 filtered filter VBN cord-018017-c8myq6bi 166 25 lysate lysate NN cord-018017-c8myq6bi 166 26 into into IN cord-018017-c8myq6bi 166 27 chickens chicken NNS cord-018017-c8myq6bi 166 28 . . . cord-018017-c8myq6bi 167 1 A a DT cord-018017-c8myq6bi 167 2 tumor tumor NN cord-018017-c8myq6bi 167 3 developed develop VBN cord-018017-c8myq6bi 167 4 at at IN cord-018017-c8myq6bi 167 5 the the DT cord-018017-c8myq6bi 167 6 injection injection NN cord-018017-c8myq6bi 167 7 site site NN cord-018017-c8myq6bi 167 8 . . . cord-018017-c8myq6bi 168 1 The the DT cord-018017-c8myq6bi 168 2 virus virus NN cord-018017-c8myq6bi 168 3 is be VBZ cord-018017-c8myq6bi 168 4 now now RB cord-018017-c8myq6bi 168 5 known know VBN cord-018017-c8myq6bi 168 6 as as IN cord-018017-c8myq6bi 168 7 Rous Rous NNP cord-018017-c8myq6bi 168 8 Sarcoma Sarcoma NNP cord-018017-c8myq6bi 168 9 Virus Virus NNP cord-018017-c8myq6bi 168 10 ( ( -LRB- cord-018017-c8myq6bi 168 11 RSV RSV NNP cord-018017-c8myq6bi 168 12 ) ) -RRB- cord-018017-c8myq6bi 168 13 , , , cord-018017-c8myq6bi 168 14 a a DT cord-018017-c8myq6bi 168 15 single single RB cord-018017-c8myq6bi 168 16 - - HYPH cord-018017-c8myq6bi 168 17 stranded strand VBN cord-018017-c8myq6bi 168 18 RNA RNA NNP cord-018017-c8myq6bi 168 19 virus virus NN cord-018017-c8myq6bi 168 20 . . . cord-018017-c8myq6bi 169 1 Rous Rous NNP cord-018017-c8myq6bi 169 2 won win VBD cord-018017-c8myq6bi 169 3 a a DT cord-018017-c8myq6bi 169 4 Nobel Nobel NNP cord-018017-c8myq6bi 169 5 Prize Prize NNP cord-018017-c8myq6bi 169 6 in in IN cord-018017-c8myq6bi 169 7 Physiology Physiology NNP cord-018017-c8myq6bi 169 8 or or CC cord-018017-c8myq6bi 169 9 Medicine Medicine NNP cord-018017-c8myq6bi 169 10 for for IN cord-018017-c8myq6bi 169 11 the the DT cord-018017-c8myq6bi 169 12 discovery discovery NN cord-018017-c8myq6bi 169 13 in in IN cord-018017-c8myq6bi 169 14 1966 1966 CD cord-018017-c8myq6bi 169 15 . . . cord-018017-c8myq6bi 170 1 RSV RSV NNP cord-018017-c8myq6bi 170 2 is be VBZ cord-018017-c8myq6bi 170 3 a a DT cord-018017-c8myq6bi 170 4 retrovirus retrovirus NN cord-018017-c8myq6bi 170 5 that that WDT cord-018017-c8myq6bi 170 6 captured capture VBD cord-018017-c8myq6bi 170 7 a a DT cord-018017-c8myq6bi 170 8 tyrosine tyrosine NN cord-018017-c8myq6bi 170 9 kinase kinase NN cord-018017-c8myq6bi 170 10 , , , cord-018017-c8myq6bi 170 11 src src NNP cord-018017-c8myq6bi 170 12 gene gene NN cord-018017-c8myq6bi 170 13 , , , cord-018017-c8myq6bi 170 14 that that WDT cord-018017-c8myq6bi 170 15 triggers trigger VBZ cord-018017-c8myq6bi 170 16 uncontrolled uncontrolled JJ cord-018017-c8myq6bi 170 17 growth growth NN cord-018017-c8myq6bi 170 18 in in IN cord-018017-c8myq6bi 170 19 infected infected JJ cord-018017-c8myq6bi 170 20 host host NN cord-018017-c8myq6bi 170 21 cells cell NNS cord-018017-c8myq6bi 170 22 . . . cord-018017-c8myq6bi 171 1 The the DT cord-018017-c8myq6bi 171 2 Avian Avian NNP cord-018017-c8myq6bi 171 3 Leukemia Leukemia NNP cord-018017-c8myq6bi 171 4 Virus Virus NNP cord-018017-c8myq6bi 171 5 ( ( -LRB- cord-018017-c8myq6bi 171 6 ALV ALV NNP cord-018017-c8myq6bi 171 7 ) ) -RRB- cord-018017-c8myq6bi 171 8 was be VBD cord-018017-c8myq6bi 171 9 discovered discover VBN cord-018017-c8myq6bi 171 10 in in IN cord-018017-c8myq6bi 171 11 Denmark Denmark NNP cord-018017-c8myq6bi 171 12 early early RB cord-018017-c8myq6bi 171 13 in in IN cord-018017-c8myq6bi 171 14 the the DT cord-018017-c8myq6bi 171 15 twentieth twentieth JJ cord-018017-c8myq6bi 171 16 century century NN cord-018017-c8myq6bi 171 17 capable capable JJ cord-018017-c8myq6bi 171 18 of of IN cord-018017-c8myq6bi 171 19 causing cause VBG cord-018017-c8myq6bi 171 20 disease disease NN cord-018017-c8myq6bi 171 21 in in IN cord-018017-c8myq6bi 171 22 blood blood NN cord-018017-c8myq6bi 171 23 forming form VBG cord-018017-c8myq6bi 171 24 tissues tissue NNS cord-018017-c8myq6bi 171 25 of of IN cord-018017-c8myq6bi 171 26 chickens chicken NNS cord-018017-c8myq6bi 171 27 . . . cord-018017-c8myq6bi 172 1 A a DT cord-018017-c8myq6bi 172 2 strain strain NN cord-018017-c8myq6bi 172 3 of of IN cord-018017-c8myq6bi 172 4 ALV ALV NNP cord-018017-c8myq6bi 172 5 , , , cord-018017-c8myq6bi 172 6 avian avian JJ cord-018017-c8myq6bi 172 7 myeloblastosis myeloblastosis NN cord-018017-c8myq6bi 172 8 virus virus NN cord-018017-c8myq6bi 172 9 ( ( -LRB- cord-018017-c8myq6bi 172 10 AMV AMV NNP cord-018017-c8myq6bi 172 11 ) ) -RRB- cord-018017-c8myq6bi 172 12 was be VBD cord-018017-c8myq6bi 172 13 described describe VBN cord-018017-c8myq6bi 172 14 in in IN cord-018017-c8myq6bi 172 15 1952 1952 CD cord-018017-c8myq6bi 172 16 that that WDT cord-018017-c8myq6bi 172 17 provided provide VBD cord-018017-c8myq6bi 172 18 a a DT cord-018017-c8myq6bi 172 19 convenient convenient JJ cord-018017-c8myq6bi 172 20 source source NN cord-018017-c8myq6bi 172 21 of of IN cord-018017-c8myq6bi 172 22 tissue tissue NN cord-018017-c8myq6bi 172 23 for for IN cord-018017-c8myq6bi 172 24 biochemical biochemical JJ cord-018017-c8myq6bi 172 25 studies study NNS cord-018017-c8myq6bi 172 26 . . . cord-018017-c8myq6bi 173 1 During during IN cord-018017-c8myq6bi 173 2 the the DT cord-018017-c8myq6bi 173 3 1930s 1930 NNS cord-018017-c8myq6bi 173 4 a a DT cord-018017-c8myq6bi 173 5 strain strain NN cord-018017-c8myq6bi 173 6 of of IN cord-018017-c8myq6bi 173 7 inbred inbred JJ cord-018017-c8myq6bi 173 8 mice mouse NNS cord-018017-c8myq6bi 173 9 was be VBD cord-018017-c8myq6bi 173 10 found find VBN cord-018017-c8myq6bi 173 11 to to TO cord-018017-c8myq6bi 173 12 develop develop VB cord-018017-c8myq6bi 173 13 leukemia leukemia NN cord-018017-c8myq6bi 173 14 between between IN cord-018017-c8myq6bi 173 15 6 6 CD cord-018017-c8myq6bi 173 16 and and CC cord-018017-c8myq6bi 173 17 18 18 CD cord-018017-c8myq6bi 173 18 months month NNS cord-018017-c8myq6bi 173 19 of of IN cord-018017-c8myq6bi 173 20 ( ( -LRB- cord-018017-c8myq6bi 173 21 Burkitt Burkitt NNP cord-018017-c8myq6bi 173 22 's 's POS cord-018017-c8myq6bi 173 23 Lymphoma Lymphoma NNP cord-018017-c8myq6bi 173 24 2014 2014 CD cord-018017-c8myq6bi 173 25 ) ) -RRB- cord-018017-c8myq6bi 173 26 . . . cord-018017-c8myq6bi 174 1 After after IN cord-018017-c8myq6bi 174 2 that that DT cord-018017-c8myq6bi 174 3 he -PRON- PRP cord-018017-c8myq6bi 174 4 saw see VBD cord-018017-c8myq6bi 174 5 a a DT cord-018017-c8myq6bi 174 6 second second JJ cord-018017-c8myq6bi 174 7 case case NN cord-018017-c8myq6bi 174 8 at at IN cord-018017-c8myq6bi 174 9 the the DT cord-018017-c8myq6bi 174 10 Jinja Jinja NNP cord-018017-c8myq6bi 174 11 district district NN cord-018017-c8myq6bi 174 12 hospital hospital NN cord-018017-c8myq6bi 174 13 on on IN cord-018017-c8myq6bi 174 14 the the DT cord-018017-c8myq6bi 174 15 shores shore NNS cord-018017-c8myq6bi 174 16 of of IN cord-018017-c8myq6bi 174 17 Lake Lake NNP cord-018017-c8myq6bi 174 18 Victoria Victoria NNP cord-018017-c8myq6bi 175 1 this this DT cord-018017-c8myq6bi 175 2 became become VBD cord-018017-c8myq6bi 175 3 more more JJR cord-018017-c8myq6bi 175 4 than than IN cord-018017-c8myq6bi 175 5 a a DT cord-018017-c8myq6bi 175 6 curiosity curiosity NN cord-018017-c8myq6bi 175 7 . . . cord-018017-c8myq6bi 176 1 A a DT cord-018017-c8myq6bi 176 2 review review NN cord-018017-c8myq6bi 176 3 of of IN cord-018017-c8myq6bi 176 4 hospital hospital NN cord-018017-c8myq6bi 176 5 case case NN cord-018017-c8myq6bi 176 6 notes note NNS cord-018017-c8myq6bi 176 7 confirmed confirm VBD cord-018017-c8myq6bi 176 8 the the DT cord-018017-c8myq6bi 176 9 prevalence prevalence NN cord-018017-c8myq6bi 176 10 of of IN cord-018017-c8myq6bi 176 11 these these DT cord-018017-c8myq6bi 176 12 tumors tumor NNS cord-018017-c8myq6bi 176 13 of of IN cord-018017-c8myq6bi 176 14 the the DT cord-018017-c8myq6bi 176 15 jaw jaw NN cord-018017-c8myq6bi 176 16 and and CC cord-018017-c8myq6bi 176 17 they -PRON- PRP cord-018017-c8myq6bi 176 18 were be VBD cord-018017-c8myq6bi 176 19 accompanied accompany VBN cord-018017-c8myq6bi 176 20 by by IN cord-018017-c8myq6bi 176 21 swellings swelling NNS cord-018017-c8myq6bi 176 22 in in IN cord-018017-c8myq6bi 176 23 kidneys kidney NNS cord-018017-c8myq6bi 176 24 , , , cord-018017-c8myq6bi 176 25 ovaries ovary NNS cord-018017-c8myq6bi 176 26 , , , cord-018017-c8myq6bi 176 27 adrenal adrenal JJ cord-018017-c8myq6bi 176 28 glands gland NNS cord-018017-c8myq6bi 176 29 and and CC cord-018017-c8myq6bi 176 30 liver liver NN cord-018017-c8myq6bi 176 31 . . . cord-018017-c8myq6bi 177 1 He -PRON- PRP cord-018017-c8myq6bi 177 2 assembled assemble VBD cord-018017-c8myq6bi 177 3 data datum NNS cord-018017-c8myq6bi 177 4 from from IN cord-018017-c8myq6bi 177 5 38 38 CD cord-018017-c8myq6bi 177 6 patients patient NNS cord-018017-c8myq6bi 177 7 and and CC cord-018017-c8myq6bi 177 8 histological histological JJ cord-018017-c8myq6bi 177 9 examination examination NN cord-018017-c8myq6bi 177 10 led lead VBD cord-018017-c8myq6bi 177 11 to to IN cord-018017-c8myq6bi 177 12 description description NN cord-018017-c8myq6bi 177 13 of of IN cord-018017-c8myq6bi 177 14 " " `` cord-018017-c8myq6bi 177 15 lymphoma lymphoma NNP cord-018017-c8myq6bi 177 16 syndrome syndrome NN cord-018017-c8myq6bi 177 17 " " '' cord-018017-c8myq6bi 177 18 or or CC cord-018017-c8myq6bi 177 19 the the DT cord-018017-c8myq6bi 177 20 " " `` cord-018017-c8myq6bi 177 21 African african JJ cord-018017-c8myq6bi 177 22 Lymphoma Lymphoma NNP cord-018017-c8myq6bi 177 23 . . . cord-018017-c8myq6bi 177 24 " " '' cord-018017-c8myq6bi 178 1 Burkitt Burkitt NNP cord-018017-c8myq6bi 178 2 received receive VBD cord-018017-c8myq6bi 178 3 a a DT cord-018017-c8myq6bi 178 4 grant grant NN cord-018017-c8myq6bi 178 5 in in IN cord-018017-c8myq6bi 178 6 1961 1961 CD cord-018017-c8myq6bi 178 7 for for IN cord-018017-c8myq6bi 178 8 ₤250 ₤250 JJ cord-018017-c8myq6bi 178 9 to to TO cord-018017-c8myq6bi 178 10 visit visit VB cord-018017-c8myq6bi 178 11 57 57 CD cord-018017-c8myq6bi 178 12 hospitals hospital NNS cord-018017-c8myq6bi 178 13 in in IN cord-018017-c8myq6bi 178 14 eight eight CD cord-018017-c8myq6bi 178 15 African african JJ cord-018017-c8myq6bi 178 16 countries country NNS cord-018017-c8myq6bi 178 17 ; ; : cord-018017-c8myq6bi 178 18 Uganda Uganda NNP cord-018017-c8myq6bi 178 19 , , , cord-018017-c8myq6bi 178 20 Kenya Kenya NNP cord-018017-c8myq6bi 178 21 , , , cord-018017-c8myq6bi 178 22 Tanzania Tanzania NNP cord-018017-c8myq6bi 178 23 , , , cord-018017-c8myq6bi 178 24 Malawi Malawi NNP cord-018017-c8myq6bi 178 25 , , , cord-018017-c8myq6bi 178 26 Mozambique Mozambique NNP cord-018017-c8myq6bi 178 27 , , , cord-018017-c8myq6bi 178 28 Zimbabwe Zimbabwe NNP cord-018017-c8myq6bi 178 29 , , , cord-018017-c8myq6bi 178 30 Zambia Zambia NNP cord-018017-c8myq6bi 178 31 , , , cord-018017-c8myq6bi 178 32 and and CC cord-018017-c8myq6bi 178 33 Republic Republic NNP cord-018017-c8myq6bi 178 34 of of IN cord-018017-c8myq6bi 178 35 South South NNP cord-018017-c8myq6bi 178 36 Africa Africa NNP cord-018017-c8myq6bi 178 37 to to TO cord-018017-c8myq6bi 178 38 investigate investigate VB cord-018017-c8myq6bi 178 39 African african JJ cord-018017-c8myq6bi 178 40 lymphoma lymphoma NN cord-018017-c8myq6bi 178 41 . . . cord-018017-c8myq6bi 179 1 The the DT cord-018017-c8myq6bi 179 2 tumor tumor NN cord-018017-c8myq6bi 179 3 was be VBD cord-018017-c8myq6bi 179 4 found find VBN cord-018017-c8myq6bi 179 5 everywhere everywhere RB cord-018017-c8myq6bi 179 6 at at IN cord-018017-c8myq6bi 179 7 the the DT cord-018017-c8myq6bi 179 8 equator equator NN cord-018017-c8myq6bi 179 9 in in IN cord-018017-c8myq6bi 179 10 areas area NNS cord-018017-c8myq6bi 179 11 where where WRB cord-018017-c8myq6bi 179 12 year year NN cord-018017-c8myq6bi 179 13 - - HYPH cord-018017-c8myq6bi 179 14 round round JJ cord-018017-c8myq6bi 179 15 temperature temperature NN cord-018017-c8myq6bi 179 16 was be VBD cord-018017-c8myq6bi 179 17 above above IN cord-018017-c8myq6bi 179 18 60 60 CD cord-018017-c8myq6bi 179 19 ° ° NN cord-018017-c8myq6bi 179 20 C c NN cord-018017-c8myq6bi 179 21 but but CC cord-018017-c8myq6bi 179 22 not not RB cord-018017-c8myq6bi 179 23 in in IN cord-018017-c8myq6bi 179 24 areas area NNS cord-018017-c8myq6bi 179 25 over over IN cord-018017-c8myq6bi 179 26 5000 5000 CD cord-018017-c8myq6bi 179 27 feet foot NNS cord-018017-c8myq6bi 179 28 in in IN cord-018017-c8myq6bi 179 29 elevation elevation NN cord-018017-c8myq6bi 179 30 . . . cord-018017-c8myq6bi 180 1 Burkitt Burkitt NNP cord-018017-c8myq6bi 180 2 further further RB cord-018017-c8myq6bi 180 3 determined determine VBD cord-018017-c8myq6bi 180 4 the the DT cord-018017-c8myq6bi 180 5 tumors tumor NNS cord-018017-c8myq6bi 180 6 only only RB cord-018017-c8myq6bi 180 7 occurred occur VBD cord-018017-c8myq6bi 180 8 where where WRB cord-018017-c8myq6bi 180 9 the the DT cord-018017-c8myq6bi 180 10 annual annual JJ cord-018017-c8myq6bi 180 11 rainfall rainfall NN cord-018017-c8myq6bi 180 12 was be VBD cord-018017-c8myq6bi 180 13 above above IN cord-018017-c8myq6bi 180 14 20 20 CD cord-018017-c8myq6bi 180 15 inches inch NNS cord-018017-c8myq6bi 180 16 and and CC cord-018017-c8myq6bi 180 17 not not RB cord-018017-c8myq6bi 180 18 seen see VBN cord-018017-c8myq6bi 180 19 in in IN cord-018017-c8myq6bi 180 20 the the DT cord-018017-c8myq6bi 180 21 dry dry JJ cord-018017-c8myq6bi 180 22 savannah savannah NN cord-018017-c8myq6bi 180 23 of of IN cord-018017-c8myq6bi 180 24 Nigeria Nigeria NNP cord-018017-c8myq6bi 180 25 . . . cord-018017-c8myq6bi 181 1 Burkitt Burkitt NNP cord-018017-c8myq6bi 181 2 contacted contact VBD cord-018017-c8myq6bi 181 3 doctors doctor NNS cord-018017-c8myq6bi 181 4 in in IN cord-018017-c8myq6bi 181 5 Papua Papua NNP cord-018017-c8myq6bi 181 6 New New NNP cord-018017-c8myq6bi 181 7 Guinea Guinea NNP cord-018017-c8myq6bi 181 8 to to TO cord-018017-c8myq6bi 181 9 discover discover VB cord-018017-c8myq6bi 181 10 these these DT cord-018017-c8myq6bi 181 11 tumors tumor NNS cord-018017-c8myq6bi 181 12 were be VBD cord-018017-c8myq6bi 181 13 the the DT cord-018017-c8myq6bi 181 14 most most RBS cord-018017-c8myq6bi 181 15 common common JJ cord-018017-c8myq6bi 181 16 childhood childhood NN cord-018017-c8myq6bi 181 17 tumor tumor NN cord-018017-c8myq6bi 181 18 in in IN cord-018017-c8myq6bi 181 19 that that DT cord-018017-c8myq6bi 181 20 country country NN cord-018017-c8myq6bi 181 21 but but CC cord-018017-c8myq6bi 181 22 only only RB cord-018017-c8myq6bi 181 23 in in IN cord-018017-c8myq6bi 181 24 wet wet JJ cord-018017-c8myq6bi 181 25 coastal coastal JJ cord-018017-c8myq6bi 181 26 regions region NNS cord-018017-c8myq6bi 181 27 and and CC cord-018017-c8myq6bi 181 28 not not RB cord-018017-c8myq6bi 181 29 in in IN cord-018017-c8myq6bi 181 30 the the DT cord-018017-c8myq6bi 181 31 dry dry JJ cord-018017-c8myq6bi 181 32 highland highland NN cord-018017-c8myq6bi 181 33 areas area NNS cord-018017-c8myq6bi 181 34 . . . cord-018017-c8myq6bi 182 1 Burkitt Burkitt NNP cord-018017-c8myq6bi 182 2 's 's POS cord-018017-c8myq6bi 182 3 working working NN cord-018017-c8myq6bi 182 4 hypothesis hypothesis NN cord-018017-c8myq6bi 182 5 was be VBD cord-018017-c8myq6bi 182 6 that that IN cord-018017-c8myq6bi 182 7 an an DT cord-018017-c8myq6bi 182 8 insect insect NN cord-018017-c8myq6bi 182 9 transmitted transmit VBN cord-018017-c8myq6bi 182 10 virus virus NN cord-018017-c8myq6bi 182 11 infection infection NN cord-018017-c8myq6bi 182 12 was be VBD cord-018017-c8myq6bi 182 13 responsible responsible JJ cord-018017-c8myq6bi 182 14 for for IN cord-018017-c8myq6bi 182 15 the the DT cord-018017-c8myq6bi 182 16 lymphoma lymphoma NN cord-018017-c8myq6bi 182 17 syndrome syndrome NN cord-018017-c8myq6bi 182 18 . . . cord-018017-c8myq6bi 183 1 He -PRON- PRP cord-018017-c8myq6bi 183 2 then then RB cord-018017-c8myq6bi 183 3 observed observe VBD cord-018017-c8myq6bi 183 4 adults adult NNS cord-018017-c8myq6bi 183 5 with with IN cord-018017-c8myq6bi 183 6 the the DT cord-018017-c8myq6bi 183 7 lymphoma lymphoma NN cord-018017-c8myq6bi 183 8 but but CC cord-018017-c8myq6bi 183 9 only only RB cord-018017-c8myq6bi 183 10 in in IN cord-018017-c8myq6bi 183 11 individuals individual NNS cord-018017-c8myq6bi 183 12 that that WDT cord-018017-c8myq6bi 183 13 moved move VBD cord-018017-c8myq6bi 183 14 into into IN cord-018017-c8myq6bi 183 15 the the DT cord-018017-c8myq6bi 183 16 " " `` cord-018017-c8myq6bi 183 17 African african JJ cord-018017-c8myq6bi 183 18 lymphoma lymphoma NN cord-018017-c8myq6bi 183 19 belt belt NN cord-018017-c8myq6bi 183 20 . . . cord-018017-c8myq6bi 183 21 " " '' cord-018017-c8myq6bi 184 1 These these DT cord-018017-c8myq6bi 184 2 tumors tumor NNS cord-018017-c8myq6bi 184 3 were be VBD cord-018017-c8myq6bi 184 4 then then RB cord-018017-c8myq6bi 184 5 observed observe VBN cord-018017-c8myq6bi 184 6 in in IN cord-018017-c8myq6bi 184 7 the the DT cord-018017-c8myq6bi 184 8 United United NNP cord-018017-c8myq6bi 184 9 States States NNP cord-018017-c8myq6bi 184 10 and and CC cord-018017-c8myq6bi 184 11 Europe Europe NNP cord-018017-c8myq6bi 184 12 at at IN cord-018017-c8myq6bi 184 13 a a DT cord-018017-c8myq6bi 184 14 rate rate NN cord-018017-c8myq6bi 184 15 of of IN cord-018017-c8myq6bi 184 16 1 1 CD cord-018017-c8myq6bi 184 17 - - SYM cord-018017-c8myq6bi 184 18 3 3 CD cord-018017-c8myq6bi 184 19 per per IN cord-018017-c8myq6bi 184 20 million million CD cord-018017-c8myq6bi 184 21 or or CC cord-018017-c8myq6bi 184 22 about about IN cord-018017-c8myq6bi 184 23 100X 100x CD cord-018017-c8myq6bi 184 24 less less RBR cord-018017-c8myq6bi 184 25 frequently frequently RB cord-018017-c8myq6bi 184 26 than than IN cord-018017-c8myq6bi 184 27 in in IN cord-018017-c8myq6bi 184 28 Africa Africa NNP cord-018017-c8myq6bi 184 29 . . . cord-018017-c8myq6bi 185 1 Biopsy biopsy NN cord-018017-c8myq6bi 185 2 samples sample NNS cord-018017-c8myq6bi 185 3 did do VBD cord-018017-c8myq6bi 185 4 produce produce VB cord-018017-c8myq6bi 185 5 viruses virus NNS cord-018017-c8myq6bi 185 6 but but CC cord-018017-c8myq6bi 185 7 none none NN cord-018017-c8myq6bi 185 8 that that WDT cord-018017-c8myq6bi 185 9 came come VBD cord-018017-c8myq6bi 185 10 from from IN cord-018017-c8myq6bi 185 11 insects insect NNS cord-018017-c8myq6bi 185 12 so so IN cord-018017-c8myq6bi 185 13 the the DT cord-018017-c8myq6bi 185 14 working work VBG cord-018017-c8myq6bi 185 15 hypothesis hypothesis NN cord-018017-c8myq6bi 185 16 was be VBD cord-018017-c8myq6bi 185 17 abandoned abandon VBN cord-018017-c8myq6bi 185 18 . . . cord-018017-c8myq6bi 186 1 A a DT cord-018017-c8myq6bi 186 2 new new JJ cord-018017-c8myq6bi 186 3 hypothesis hypothesis NN cord-018017-c8myq6bi 186 4 emerged emerge VBD cord-018017-c8myq6bi 186 5 between between IN cord-018017-c8myq6bi 186 6 1963 1963 CD cord-018017-c8myq6bi 186 7 and and CC cord-018017-c8myq6bi 186 8 1966 1966 CD cord-018017-c8myq6bi 186 9 in in IN cord-018017-c8myq6bi 186 10 which which WDT cord-018017-c8myq6bi 186 11 P p NN cord-018017-c8myq6bi 186 12 falciparum falciparum NN cord-018017-c8myq6bi 186 13 ( ( -LRB- cord-018017-c8myq6bi 186 14 a a DT cord-018017-c8myq6bi 186 15 parasite parasite NN cord-018017-c8myq6bi 186 16 causing cause VBG cord-018017-c8myq6bi 186 17 malaria malaria NN cord-018017-c8myq6bi 186 18 ) ) -RRB- cord-018017-c8myq6bi 186 19 was be VBD cord-018017-c8myq6bi 186 20 the the DT cord-018017-c8myq6bi 186 21 causative causative JJ cord-018017-c8myq6bi 186 22 agent agent NN cord-018017-c8myq6bi 186 23 for for IN cord-018017-c8myq6bi 186 24 the the DT cord-018017-c8myq6bi 186 25 lymphoma lymphoma NN cord-018017-c8myq6bi 186 26 . . . cord-018017-c8myq6bi 187 1 It -PRON- PRP cord-018017-c8myq6bi 187 2 is be VBZ cord-018017-c8myq6bi 187 3 believed believe VBN cord-018017-c8myq6bi 187 4 that that IN cord-018017-c8myq6bi 187 5 severe severe JJ cord-018017-c8myq6bi 187 6 malaria malaria NN cord-018017-c8myq6bi 187 7 does do VBZ cord-018017-c8myq6bi 187 8 play play VB cord-018017-c8myq6bi 187 9 a a DT cord-018017-c8myq6bi 187 10 role role NN cord-018017-c8myq6bi 187 11 in in IN cord-018017-c8myq6bi 187 12 the the DT cord-018017-c8myq6bi 187 13 development development NN cord-018017-c8myq6bi 187 14 of of IN cord-018017-c8myq6bi 187 15 Burkitt Burkitt NNP cord-018017-c8myq6bi 187 16 's 's POS cord-018017-c8myq6bi 187 17 lymphoma lymphoma NN cord-018017-c8myq6bi 187 18 . . . cord-018017-c8myq6bi 188 1 At at IN cord-018017-c8myq6bi 188 2 the the DT cord-018017-c8myq6bi 188 3 advice advice NN cord-018017-c8myq6bi 188 4 of of IN cord-018017-c8myq6bi 188 5 Peter Peter NNP cord-018017-c8myq6bi 188 6 Clifford Clifford NNP cord-018017-c8myq6bi 188 7 , , , cord-018017-c8myq6bi 188 8 Burkitt Burkitt NNP cord-018017-c8myq6bi 188 9 administered administer VBD cord-018017-c8myq6bi 188 10 methotrexate methotrexate NNP cord-018017-c8myq6bi 188 11 to to TO cord-018017-c8myq6bi 188 12 treat treat VB cord-018017-c8myq6bi 188 13 patients patient NNS cord-018017-c8myq6bi 188 14 which which WDT cord-018017-c8myq6bi 188 15 produced produce VBD cord-018017-c8myq6bi 188 16 encouraging encouraging JJ cord-018017-c8myq6bi 188 17 results result NNS cord-018017-c8myq6bi 188 18 . . . cord-018017-c8myq6bi 189 1 In in IN cord-018017-c8myq6bi 189 2 1961 1961 CD cord-018017-c8myq6bi 189 3 Burkitt Burkitt NNP cord-018017-c8myq6bi 189 4 gave give VBD cord-018017-c8myq6bi 189 5 a a DT cord-018017-c8myq6bi 189 6 lecture lecture NN cord-018017-c8myq6bi 189 7 at at IN cord-018017-c8myq6bi 189 8 Middlesex Middlesex NNP cord-018017-c8myq6bi 189 9 Hospital Hospital NNP cord-018017-c8myq6bi 189 10 , , , cord-018017-c8myq6bi 189 11 " " `` cord-018017-c8myq6bi 189 12 The the DT cord-018017-c8myq6bi 189 13 Commonest common JJS cord-018017-c8myq6bi 189 14 Children Children NNPS cord-018017-c8myq6bi 189 15 's 's POS cord-018017-c8myq6bi 189 16 Cancer Cancer NNP cord-018017-c8myq6bi 189 17 in in IN cord-018017-c8myq6bi 189 18 Tropical Tropical NNP cord-018017-c8myq6bi 189 19 Africa Africa NNP cord-018017-c8myq6bi 189 20 : : : cord-018017-c8myq6bi 189 21 A a DT cord-018017-c8myq6bi 189 22 Hitherto hitherto JJ cord-018017-c8myq6bi 189 23 Unrecognized unrecognized JJ cord-018017-c8myq6bi 189 24 Syndrome syndrome NN cord-018017-c8myq6bi 189 25 . . . cord-018017-c8myq6bi 189 26 " " '' cord-018017-c8myq6bi 190 1 Anthony Anthony NNP cord-018017-c8myq6bi 190 2 Epstein Epstein NNP cord-018017-c8myq6bi 190 3 attended attend VBD cord-018017-c8myq6bi 190 4 the the DT cord-018017-c8myq6bi 190 5 lecture lecture NN cord-018017-c8myq6bi 190 6 which which WDT cord-018017-c8myq6bi 190 7 changed change VBD cord-018017-c8myq6bi 190 8 his -PRON- PRP$ cord-018017-c8myq6bi 190 9 life life NN cord-018017-c8myq6bi 190 10 and and CC cord-018017-c8myq6bi 190 11 provides provide VBZ cord-018017-c8myq6bi 190 12 a a DT cord-018017-c8myq6bi 190 13 punctuation punctuation NN cord-018017-c8myq6bi 190 14 mark mark NN cord-018017-c8myq6bi 190 15 in in IN cord-018017-c8myq6bi 190 16 the the DT cord-018017-c8myq6bi 190 17 history history NN cord-018017-c8myq6bi 190 18 of of IN cord-018017-c8myq6bi 190 19 science science NN cord-018017-c8myq6bi 190 20 . . . cord-018017-c8myq6bi 191 1 Epstein Epstein NNP cord-018017-c8myq6bi 191 2 introduced introduce VBD cord-018017-c8myq6bi 191 3 himself -PRON- PRP cord-018017-c8myq6bi 191 4 after after IN cord-018017-c8myq6bi 191 5 the the DT cord-018017-c8myq6bi 191 6 lecture lecture NN cord-018017-c8myq6bi 191 7 and and CC cord-018017-c8myq6bi 191 8 the the DT cord-018017-c8myq6bi 191 9 two two CD cord-018017-c8myq6bi 191 10 sat sit VBD cord-018017-c8myq6bi 191 11 down down RP cord-018017-c8myq6bi 191 12 for for IN cord-018017-c8myq6bi 191 13 tea tea NN cord-018017-c8myq6bi 191 14 . . . cord-018017-c8myq6bi 192 1 Burkitt Burkitt NNP cord-018017-c8myq6bi 192 2 agreed agree VBD cord-018017-c8myq6bi 192 3 to to TO cord-018017-c8myq6bi 192 4 send send VB cord-018017-c8myq6bi 192 5 tumor tumor NN cord-018017-c8myq6bi 192 6 specimens specimen NNS cord-018017-c8myq6bi 192 7 to to IN cord-018017-c8myq6bi 192 8 Epstein Epstein NNP cord-018017-c8myq6bi 192 9 and and CC cord-018017-c8myq6bi 192 10 Epstein Epstein NNP cord-018017-c8myq6bi 192 11 received receive VBD cord-018017-c8myq6bi 192 12 a a DT cord-018017-c8myq6bi 192 13 grant grant NN cord-018017-c8myq6bi 192 14 from from IN cord-018017-c8myq6bi 192 15 the the DT cord-018017-c8myq6bi 192 16 US US NNP cord-018017-c8myq6bi 192 17 National National NNP cord-018017-c8myq6bi 192 18 Institutes Institutes NNPS cord-018017-c8myq6bi 192 19 of of IN cord-018017-c8myq6bi 192 20 Health Health NNP cord-018017-c8myq6bi 192 21 in in IN cord-018017-c8myq6bi 192 22 1963 1963 CD cord-018017-c8myq6bi 192 23 for for IN cord-018017-c8myq6bi 192 24 $ $ $ cord-018017-c8myq6bi 192 25 45,000 45,000 CD cord-018017-c8myq6bi 192 26 which which WDT cord-018017-c8myq6bi 192 27 allowed allow VBD cord-018017-c8myq6bi 192 28 him -PRON- PRP cord-018017-c8myq6bi 192 29 to to TO cord-018017-c8myq6bi 192 30 employ employ VB cord-018017-c8myq6bi 192 31 two two CD cord-018017-c8myq6bi 192 32 research research NN cord-018017-c8myq6bi 192 33 assistants assistant NNS cord-018017-c8myq6bi 192 34 . . . cord-018017-c8myq6bi 193 1 Yvonne Yvonne NNP cord-018017-c8myq6bi 193 2 Barr Barr NNP cord-018017-c8myq6bi 193 3 was be VBD cord-018017-c8myq6bi 193 4 one one CD cord-018017-c8myq6bi 193 5 of of IN cord-018017-c8myq6bi 193 6 the the DT cord-018017-c8myq6bi 193 7 research research NN cord-018017-c8myq6bi 193 8 assistants assistant NNS cord-018017-c8myq6bi 193 9 that that WDT cord-018017-c8myq6bi 193 10 was be VBD cord-018017-c8myq6bi 193 11 able able JJ cord-018017-c8myq6bi 193 12 to to TO cord-018017-c8myq6bi 193 13 propagate propagate VB cord-018017-c8myq6bi 193 14 a a DT cord-018017-c8myq6bi 193 15 virus virus NN cord-018017-c8myq6bi 193 16 after after IN cord-018017-c8myq6bi 193 17 26 26 CD cord-018017-c8myq6bi 193 18 tries try NNS cord-018017-c8myq6bi 193 19 with with IN cord-018017-c8myq6bi 193 20 tumor tumor NN cord-018017-c8myq6bi 193 21 specimens specimen NNS cord-018017-c8myq6bi 193 22 . . . cord-018017-c8myq6bi 194 1 The the DT cord-018017-c8myq6bi 194 2 other other JJ cord-018017-c8myq6bi 194 3 research research NN cord-018017-c8myq6bi 194 4 assistant assistant NN cord-018017-c8myq6bi 194 5 was be VBD cord-018017-c8myq6bi 194 6 Bert Bert NNP cord-018017-c8myq6bi 194 7 Achong Achong NNP cord-018017-c8myq6bi 194 8 , , , cord-018017-c8myq6bi 194 9 an an DT cord-018017-c8myq6bi 194 10 electron electron NN cord-018017-c8myq6bi 194 11 microscopist microscopist NN cord-018017-c8myq6bi 194 12 , , , cord-018017-c8myq6bi 194 13 who who WP cord-018017-c8myq6bi 194 14 was be VBD cord-018017-c8myq6bi 194 15 first first JJ cord-018017-c8myq6bi 194 16 to to TO cord-018017-c8myq6bi 194 17 identify identify VB cord-018017-c8myq6bi 194 18 the the DT cord-018017-c8myq6bi 194 19 virus virus NN cord-018017-c8myq6bi 194 20 as as IN cord-018017-c8myq6bi 194 21 a a DT cord-018017-c8myq6bi 194 22 member member NN cord-018017-c8myq6bi 194 23 of of IN cord-018017-c8myq6bi 194 24 the the DT cord-018017-c8myq6bi 194 25 Herpes Herpes NNP cord-018017-c8myq6bi 194 26 Virus Virus NNP cord-018017-c8myq6bi 194 27 family family NN cord-018017-c8myq6bi 194 28 . . . cord-018017-c8myq6bi 195 1 The the DT cord-018017-c8myq6bi 195 2 virus virus NN cord-018017-c8myq6bi 195 3 bears bear VBZ cord-018017-c8myq6bi 195 4 the the DT cord-018017-c8myq6bi 195 5 name name NN cord-018017-c8myq6bi 195 6 Epstein Epstein NNP cord-018017-c8myq6bi 195 7 Barr Barr NNP cord-018017-c8myq6bi 195 8 Virus Virus NNP cord-018017-c8myq6bi 195 9 or or CC cord-018017-c8myq6bi 195 10 EBV EBV NNP cord-018017-c8myq6bi 195 11 and and CC cord-018017-c8myq6bi 195 12 is be VBZ cord-018017-c8myq6bi 195 13 a a DT cord-018017-c8myq6bi 195 14 causative causative JJ cord-018017-c8myq6bi 195 15 agent agent NN cord-018017-c8myq6bi 195 16 of of IN cord-018017-c8myq6bi 195 17 Burkitt Burkitt NNP cord-018017-c8myq6bi 195 18 's 's POS cord-018017-c8myq6bi 195 19 Lymphoma Lymphoma NNP cord-018017-c8myq6bi 195 20 . . . cord-018017-c8myq6bi 196 1 An an DT cord-018017-c8myq6bi 196 2 interesting interesting JJ cord-018017-c8myq6bi 196 3 historical historical JJ cord-018017-c8myq6bi 196 4 note note NN cord-018017-c8myq6bi 196 5 involves involve VBZ cord-018017-c8myq6bi 196 6 Werner Werner NNP cord-018017-c8myq6bi 196 7 and and CC cord-018017-c8myq6bi 196 8 Gertrude Gertrude NNP cord-018017-c8myq6bi 196 9 Henle Henle NNP cord-018017-c8myq6bi 196 10 at at IN cord-018017-c8myq6bi 196 11 the the DT cord-018017-c8myq6bi 196 12 Children Children NNPS cord-018017-c8myq6bi 196 13 's 's POS cord-018017-c8myq6bi 196 14 Hospital Hospital NNP cord-018017-c8myq6bi 196 15 of of IN cord-018017-c8myq6bi 196 16 Philadelphia Philadelphia NNP cord-018017-c8myq6bi 196 17 . . . cord-018017-c8myq6bi 197 1 They -PRON- PRP cord-018017-c8myq6bi 197 2 created create VBD cord-018017-c8myq6bi 197 3 antibodies antibody NNS cord-018017-c8myq6bi 197 4 to to IN cord-018017-c8myq6bi 197 5 EBV EBV NNP cord-018017-c8myq6bi 197 6 infected infected JJ cord-018017-c8myq6bi 197 7 cells cell NNS cord-018017-c8myq6bi 197 8 and and CC cord-018017-c8myq6bi 197 9 their -PRON- PRP$ cord-018017-c8myq6bi 197 10 survey survey NN cord-018017-c8myq6bi 197 11 of of IN cord-018017-c8myq6bi 197 12 blood blood NN cord-018017-c8myq6bi 197 13 samples sample NNS cord-018017-c8myq6bi 197 14 from from IN cord-018017-c8myq6bi 197 15 American american JJ cord-018017-c8myq6bi 197 16 adults adult NNS cord-018017-c8myq6bi 197 17 revealed reveal VBD cord-018017-c8myq6bi 197 18 over over IN cord-018017-c8myq6bi 197 19 90 90 CD cord-018017-c8myq6bi 197 20 % % NN cord-018017-c8myq6bi 197 21 to to TO cord-018017-c8myq6bi 197 22 be be VB cord-018017-c8myq6bi 197 23 EBV EBV NNP cord-018017-c8myq6bi 197 24 positive positive JJ cord-018017-c8myq6bi 197 25 in in IN cord-018017-c8myq6bi 197 26 1966 1966 CD cord-018017-c8myq6bi 197 27 . . . cord-018017-c8myq6bi 198 1 They -PRON- PRP cord-018017-c8myq6bi 198 2 also also RB cord-018017-c8myq6bi 198 3 showed show VBD cord-018017-c8myq6bi 198 4 that that IN cord-018017-c8myq6bi 198 5 normal normal JJ cord-018017-c8myq6bi 198 6 human human JJ cord-018017-c8myq6bi 198 7 lymphocytes lymphocyte NNS cord-018017-c8myq6bi 198 8 could could MD cord-018017-c8myq6bi 198 9 be be VB cord-018017-c8myq6bi 198 10 made make VBN cord-018017-c8myq6bi 198 11 immortal immortal JJ cord-018017-c8myq6bi 198 12 by by IN cord-018017-c8myq6bi 198 13 infecting infect VBG cord-018017-c8myq6bi 198 14 them -PRON- PRP cord-018017-c8myq6bi 198 15 with with IN cord-018017-c8myq6bi 198 16 EBV EBV NNP cord-018017-c8myq6bi 198 17 in in IN cord-018017-c8myq6bi 198 18 1967 1967 CD cord-018017-c8myq6bi 198 19 . . . cord-018017-c8myq6bi 199 1 We -PRON- PRP cord-018017-c8myq6bi 199 2 now now RB cord-018017-c8myq6bi 199 3 know know VBP cord-018017-c8myq6bi 199 4 EBV EBV NNP cord-018017-c8myq6bi 199 5 silently silently RB cord-018017-c8myq6bi 199 6 infects infect VBZ cord-018017-c8myq6bi 199 7 children child NNS cord-018017-c8myq6bi 199 8 in in IN cord-018017-c8myq6bi 199 9 the the DT cord-018017-c8myq6bi 199 10 Western Western NNP cord-018017-c8myq6bi 199 11 World World NNP cord-018017-c8myq6bi 199 12 but but CC cord-018017-c8myq6bi 199 13 in in IN cord-018017-c8myq6bi 199 14 those those DT cord-018017-c8myq6bi 199 15 infected infect VBN cord-018017-c8myq6bi 199 16 a a DT cord-018017-c8myq6bi 199 17 bit bit NN cord-018017-c8myq6bi 199 18 later later RB cord-018017-c8myq6bi 199 19 in in IN cord-018017-c8myq6bi 199 20 life life NN cord-018017-c8myq6bi 199 21 become become VBP cord-018017-c8myq6bi 199 22 susceptible susceptible JJ cord-018017-c8myq6bi 199 23 to to IN cord-018017-c8myq6bi 199 24 infectious infectious JJ cord-018017-c8myq6bi 199 25 mononucleosis mononucleosis NN cord-018017-c8myq6bi 199 26 ( ( -LRB- cord-018017-c8myq6bi 199 27 the the DT cord-018017-c8myq6bi 199 28 kissing kissing NN cord-018017-c8myq6bi 199 29 disease disease NN cord-018017-c8myq6bi 199 30 ) ) -RRB- cord-018017-c8myq6bi 199 31 as as IN cord-018017-c8myq6bi 199 32 adolescents adolescent NNS cord-018017-c8myq6bi 199 33 . . . cord-018017-c8myq6bi 200 1 In in IN cord-018017-c8myq6bi 200 2 1972 1972 CD cord-018017-c8myq6bi 200 3 , , , cord-018017-c8myq6bi 200 4 a a DT cord-018017-c8myq6bi 200 5 collaboration collaboration NN cord-018017-c8myq6bi 200 6 between between IN cord-018017-c8myq6bi 200 7 George George NNP cord-018017-c8myq6bi 200 8 Klein Klein NNP cord-018017-c8myq6bi 200 9 and and CC cord-018017-c8myq6bi 200 10 the the DT cord-018017-c8myq6bi 200 11 Manolovs Manolovs NNP cord-018017-c8myq6bi 200 12 led lead VBD cord-018017-c8myq6bi 200 13 to to IN cord-018017-c8myq6bi 200 14 a a DT cord-018017-c8myq6bi 200 15 discovery discovery NN cord-018017-c8myq6bi 200 16 of of IN cord-018017-c8myq6bi 200 17 a a DT cord-018017-c8myq6bi 200 18 chromosome chromosome NN cord-018017-c8myq6bi 200 19 change change NN cord-018017-c8myq6bi 200 20 that that WDT cord-018017-c8myq6bi 200 21 was be VBD cord-018017-c8myq6bi 200 22 specific specific JJ cord-018017-c8myq6bi 200 23 to to IN cord-018017-c8myq6bi 200 24 Burkitt Burkitt NNP cord-018017-c8myq6bi 200 25 's 's POS cord-018017-c8myq6bi 200 26 lymphoma lymphoma NN cord-018017-c8myq6bi 200 27 . . . cord-018017-c8myq6bi 201 1 This this DT cord-018017-c8myq6bi 201 2 chromosome chromosome NN cord-018017-c8myq6bi 201 3 change change NN cord-018017-c8myq6bi 201 4 was be VBD cord-018017-c8myq6bi 201 5 a a DT cord-018017-c8myq6bi 201 6 translocation translocation NN cord-018017-c8myq6bi 201 7 of of IN cord-018017-c8myq6bi 201 8 8:14 8:14 CD cord-018017-c8myq6bi 201 9 and and CC cord-018017-c8myq6bi 201 10 rarely rarely RB cord-018017-c8myq6bi 201 11 8:2 8:2 CD cord-018017-c8myq6bi 201 12 or or CC cord-018017-c8myq6bi 201 13 8:22 8:22 CD cord-018017-c8myq6bi 202 1 ( ( -LRB- cord-018017-c8myq6bi 202 2 Zech Zech NNP cord-018017-c8myq6bi 202 3 et et NNP cord-018017-c8myq6bi 202 4 al al NNP cord-018017-c8myq6bi 202 5 . . . cord-018017-c8myq6bi 202 6 1976 1976 CD cord-018017-c8myq6bi 202 7 ) ) -RRB- cord-018017-c8myq6bi 202 8 . . . cord-018017-c8myq6bi 203 1 The the DT cord-018017-c8myq6bi 203 2 break break NN cord-018017-c8myq6bi 203 3 points point NNS cord-018017-c8myq6bi 203 4 in in IN cord-018017-c8myq6bi 203 5 chromosomes chromosome NNS cord-018017-c8myq6bi 203 6 2 2 CD cord-018017-c8myq6bi 203 7 , , , cord-018017-c8myq6bi 203 8 14 14 CD cord-018017-c8myq6bi 203 9 , , , cord-018017-c8myq6bi 203 10 and and CC cord-018017-c8myq6bi 203 11 22 22 CD cord-018017-c8myq6bi 203 12 contained contain VBD cord-018017-c8myq6bi 203 13 immunoglobin immunoglobin NNP cord-018017-c8myq6bi 203 14 genes gene NNS cord-018017-c8myq6bi 203 15 that that WDT cord-018017-c8myq6bi 203 16 become become VBP cord-018017-c8myq6bi 203 17 active active JJ cord-018017-c8myq6bi 203 18 in in IN cord-018017-c8myq6bi 203 19 B b NN cord-018017-c8myq6bi 203 20 lymphocytes lymphocyte NNS cord-018017-c8myq6bi 203 21 as as IN cord-018017-c8myq6bi 203 22 they -PRON- PRP cord-018017-c8myq6bi 203 23 produce produce VBP cord-018017-c8myq6bi 203 24 antibodies antibody NNS cord-018017-c8myq6bi 203 25 during during IN cord-018017-c8myq6bi 203 26 infection infection NN cord-018017-c8myq6bi 203 27 . . . cord-018017-c8myq6bi 204 1 A a DT cord-018017-c8myq6bi 204 2 Nobel Nobel NNP cord-018017-c8myq6bi 204 3 Prize Prize NNP cord-018017-c8myq6bi 204 4 in in IN cord-018017-c8myq6bi 204 5 1989 1989 CD cord-018017-c8myq6bi 204 6 to to IN cord-018017-c8myq6bi 204 7 Michael Michael NNP cord-018017-c8myq6bi 204 8 Bishop Bishop NNP cord-018017-c8myq6bi 204 9 and and CC cord-018017-c8myq6bi 204 10 Harold Harold NNP cord-018017-c8myq6bi 204 11 Varmus Varmus NNP cord-018017-c8myq6bi 204 12 provided provide VBD cord-018017-c8myq6bi 204 13 the the DT cord-018017-c8myq6bi 204 14 significance significance NN cord-018017-c8myq6bi 204 15 to to IN cord-018017-c8myq6bi 204 16 the the DT cord-018017-c8myq6bi 204 17 break break NN cord-018017-c8myq6bi 204 18 point point NN cord-018017-c8myq6bi 204 19 in in IN cord-018017-c8myq6bi 204 20 chromosome chromosome NN cord-018017-c8myq6bi 204 21 8 8 CD cord-018017-c8myq6bi 204 22 , , , cord-018017-c8myq6bi 204 23 bringing bring VBG cord-018017-c8myq6bi 204 24 active active JJ cord-018017-c8myq6bi 204 25 immunoglobin immunoglobin NNP cord-018017-c8myq6bi 204 26 genes gene NNS cord-018017-c8myq6bi 204 27 near near IN cord-018017-c8myq6bi 204 28 the the DT cord-018017-c8myq6bi 204 29 oncogene oncogene NN cord-018017-c8myq6bi 204 30 c c NN cord-018017-c8myq6bi 204 31 - - HYPH cord-018017-c8myq6bi 204 32 myc myc NNP cord-018017-c8myq6bi 204 33 . . . cord-018017-c8myq6bi 205 1 In in IN cord-018017-c8myq6bi 205 2 1970 1970 CD cord-018017-c8myq6bi 205 3 , , , cord-018017-c8myq6bi 205 4 a a DT cord-018017-c8myq6bi 205 5 second second JJ cord-018017-c8myq6bi 205 6 cancer cancer NN cord-018017-c8myq6bi 205 7 common common JJ cord-018017-c8myq6bi 205 8 in in IN cord-018017-c8myq6bi 205 9 North North NNP cord-018017-c8myq6bi 205 10 and and CC cord-018017-c8myq6bi 205 11 East East NNP cord-018017-c8myq6bi 205 12 Africa Africa NNP cord-018017-c8myq6bi 205 13 as as RB cord-018017-c8myq6bi 205 14 well well RB cord-018017-c8myq6bi 205 15 as as IN cord-018017-c8myq6bi 205 16 Southern Southern NNP cord-018017-c8myq6bi 205 17 China China NNP cord-018017-c8myq6bi 205 18 was be VBD cord-018017-c8myq6bi 205 19 found find VBN cord-018017-c8myq6bi 205 20 to to TO cord-018017-c8myq6bi 205 21 be be VB cord-018017-c8myq6bi 205 22 EBV EBV NNP cord-018017-c8myq6bi 205 23 positive positive JJ cord-018017-c8myq6bi 205 24 , , , cord-018017-c8myq6bi 205 25 carcinoma carcinoma NN cord-018017-c8myq6bi 205 26 of of IN cord-018017-c8myq6bi 205 27 the the DT cord-018017-c8myq6bi 205 28 post post JJ cord-018017-c8myq6bi 205 29 - - JJ cord-018017-c8myq6bi 205 30 nasal nasal JJ cord-018017-c8myq6bi 205 31 space space NN cord-018017-c8myq6bi 205 32 ( ( -LRB- cord-018017-c8myq6bi 205 33 Nasal Nasal NNP cord-018017-c8myq6bi 205 34 Pharyngeal Pharyngeal NNP cord-018017-c8myq6bi 205 35 Carcinoma Carcinoma NNP cord-018017-c8myq6bi 205 36 or or CC cord-018017-c8myq6bi 205 37 NPC NPC NNP cord-018017-c8myq6bi 205 38 ) ) -RRB- cord-018017-c8myq6bi 205 39 . . . cord-018017-c8myq6bi 206 1 The the DT cord-018017-c8myq6bi 206 2 tumor tumor NN cord-018017-c8myq6bi 206 3 is be VBZ cord-018017-c8myq6bi 206 4 observed observe VBN cord-018017-c8myq6bi 206 5 in in IN cord-018017-c8myq6bi 206 6 epithelial epithelial JJ cord-018017-c8myq6bi 206 7 cells cell NNS cord-018017-c8myq6bi 206 8 not not RB cord-018017-c8myq6bi 206 9 B b NN cord-018017-c8myq6bi 206 10 - - HYPH cord-018017-c8myq6bi 206 11 cells cell NNS cord-018017-c8myq6bi 206 12 and and CC cord-018017-c8myq6bi 206 13 is be VBZ cord-018017-c8myq6bi 206 14 not not RB cord-018017-c8myq6bi 206 15 geographically geographically RB cord-018017-c8myq6bi 206 16 linked link VBN cord-018017-c8myq6bi 206 17 to to IN cord-018017-c8myq6bi 206 18 endemic endemic JJ cord-018017-c8myq6bi 206 19 malaria malaria NN cord-018017-c8myq6bi 206 20 regions region NNS cord-018017-c8myq6bi 206 21 . . . cord-018017-c8myq6bi 207 1 In in IN cord-018017-c8myq6bi 207 2 this this DT cord-018017-c8myq6bi 207 3 case case NN cord-018017-c8myq6bi 207 4 , , , cord-018017-c8myq6bi 207 5 it -PRON- PRP cord-018017-c8myq6bi 207 6 appears appear VBZ cord-018017-c8myq6bi 207 7 that that IN cord-018017-c8myq6bi 207 8 aerosol aerosol NN cord-018017-c8myq6bi 207 9 exposure exposure NN cord-018017-c8myq6bi 207 10 to to IN cord-018017-c8myq6bi 207 11 environmental environmental JJ cord-018017-c8myq6bi 207 12 carcinogens carcinogen NNS cord-018017-c8myq6bi 207 13 ( ( -LRB- cord-018017-c8myq6bi 207 14 possibly possibly RB cord-018017-c8myq6bi 207 15 in in IN cord-018017-c8myq6bi 207 16 preserved preserved JJ cord-018017-c8myq6bi 207 17 fish fish NN cord-018017-c8myq6bi 207 18 ) ) -RRB- cord-018017-c8myq6bi 207 19 may may MD cord-018017-c8myq6bi 207 20 introduce introduce VB cord-018017-c8myq6bi 207 21 mutations mutation NNS cord-018017-c8myq6bi 207 22 in in IN cord-018017-c8myq6bi 207 23 nasal nasal JJ cord-018017-c8myq6bi 207 24 epithelial epithelial JJ cord-018017-c8myq6bi 207 25 cells cell NNS cord-018017-c8myq6bi 207 26 . . . cord-018017-c8myq6bi 208 1 The the DT cord-018017-c8myq6bi 208 2 NPC NPC NNP cord-018017-c8myq6bi 208 3 may may MD cord-018017-c8myq6bi 208 4 be be VB cord-018017-c8myq6bi 208 5 the the DT cord-018017-c8myq6bi 208 6 result result NN cord-018017-c8myq6bi 208 7 of of IN cord-018017-c8myq6bi 208 8 silent silent JJ cord-018017-c8myq6bi 208 9 EBV EBV NNP cord-018017-c8myq6bi 208 10 infection infection NN cord-018017-c8myq6bi 208 11 , , , cord-018017-c8myq6bi 208 12 carcinogen carcinogen NN cord-018017-c8myq6bi 208 13 induced induce VBN cord-018017-c8myq6bi 208 14 cellular cellular JJ cord-018017-c8myq6bi 208 15 mutations mutation NNS cord-018017-c8myq6bi 208 16 , , , cord-018017-c8myq6bi 208 17 and and CC cord-018017-c8myq6bi 208 18 people people NNS cord-018017-c8myq6bi 208 19 carrying carry VBG cord-018017-c8myq6bi 208 20 HLA HLA NNP cord-018017-c8myq6bi 208 21 A*0207 A*0207 NNP cord-018017-c8myq6bi 208 22 and and CC cord-018017-c8myq6bi 208 23 B*46 b*46 NN cord-018017-c8myq6bi 208 24 antigens antigen NNS cord-018017-c8myq6bi 208 25 . . . cord-018017-c8myq6bi 209 1 In in IN cord-018017-c8myq6bi 209 2 1975 1975 CD cord-018017-c8myq6bi 209 3 , , , cord-018017-c8myq6bi 209 4 several several JJ cord-018017-c8myq6bi 209 5 reports report NNS cord-018017-c8myq6bi 209 6 describing describe VBG cord-018017-c8myq6bi 209 7 " " `` cord-018017-c8myq6bi 209 8 fatal fatal JJ cord-018017-c8myq6bi 209 9 infectious infectious JJ cord-018017-c8myq6bi 209 10 mononucleosis mononucleosis NN cord-018017-c8myq6bi 209 11 " " '' cord-018017-c8myq6bi 209 12 appeared appear VBD cord-018017-c8myq6bi 209 13 . . . cord-018017-c8myq6bi 210 1 David David NNP cord-018017-c8myq6bi 210 2 Purtilo Purtilo NNP cord-018017-c8myq6bi 210 3 described describe VBD cord-018017-c8myq6bi 210 4 X x NN cord-018017-c8myq6bi 210 5 - - HYPH cord-018017-c8myq6bi 210 6 linked link VBN cord-018017-c8myq6bi 210 7 proliferative proliferative JJ cord-018017-c8myq6bi 210 8 syndrome syndrome NN cord-018017-c8myq6bi 210 9 ( ( -LRB- cord-018017-c8myq6bi 210 10 XLP XLP NNP cord-018017-c8myq6bi 210 11 ) ) -RRB- cord-018017-c8myq6bi 210 12 based base VBN cord-018017-c8myq6bi 210 13 on on IN cord-018017-c8myq6bi 210 14 an an DT cord-018017-c8myq6bi 210 15 international international JJ cord-018017-c8myq6bi 210 16 registry registry NN cord-018017-c8myq6bi 210 17 of of IN cord-018017-c8myq6bi 210 18 boys boy NNS cord-018017-c8myq6bi 210 19 with with IN cord-018017-c8myq6bi 210 20 fatal fatal JJ cord-018017-c8myq6bi 210 21 EBV EBV NNP cord-018017-c8myq6bi 210 22 infections infection NNS cord-018017-c8myq6bi 210 23 ( ( -LRB- cord-018017-c8myq6bi 210 24 Purtilo Purtilo NNP cord-018017-c8myq6bi 210 25 et et FW cord-018017-c8myq6bi 210 26 al al NNP cord-018017-c8myq6bi 210 27 . . NNP cord-018017-c8myq6bi 210 28 1977 1977 CD cord-018017-c8myq6bi 210 29 ) ) -RRB- cord-018017-c8myq6bi 210 30 . . . cord-018017-c8myq6bi 211 1 Using use VBG cord-018017-c8myq6bi 211 2 genetic genetic JJ cord-018017-c8myq6bi 211 3 marker marker NN cord-018017-c8myq6bi 211 4 analysis analysis NN cord-018017-c8myq6bi 211 5 from from IN cord-018017-c8myq6bi 211 6 the the DT cord-018017-c8myq6bi 211 7 international international JJ cord-018017-c8myq6bi 211 8 registry registry NN cord-018017-c8myq6bi 211 9 they -PRON- PRP cord-018017-c8myq6bi 211 10 narrowed narrow VBD cord-018017-c8myq6bi 211 11 XLP XLP NNP cord-018017-c8myq6bi 211 12 to to IN cord-018017-c8myq6bi 211 13 a a DT cord-018017-c8myq6bi 211 14 three three CD cord-018017-c8myq6bi 211 15 million million CD cord-018017-c8myq6bi 211 16 base base NN cord-018017-c8myq6bi 211 17 pair pair NN cord-018017-c8myq6bi 211 18 segment segment NN cord-018017-c8myq6bi 211 19 on on IN cord-018017-c8myq6bi 211 20 the the DT cord-018017-c8myq6bi 211 21 X x NN cord-018017-c8myq6bi 211 22 - - NN cord-018017-c8myq6bi 211 23 chromosome chromosome NN cord-018017-c8myq6bi 211 24 . . . cord-018017-c8myq6bi 212 1 In in IN cord-018017-c8myq6bi 212 2 1998 1998 CD cord-018017-c8myq6bi 212 3 , , , cord-018017-c8myq6bi 212 4 a a DT cord-018017-c8myq6bi 212 5 384-base 384-base CD cord-018017-c8myq6bi 212 6 pair pair NN cord-018017-c8myq6bi 212 7 segment segment NN cord-018017-c8myq6bi 212 8 encoding encode VBG cord-018017-c8myq6bi 212 9 the the DT cord-018017-c8myq6bi 212 10 XLP XLP NNP cord-018017-c8myq6bi 212 11 protein protein NN cord-018017-c8myq6bi 212 12 of of IN cord-018017-c8myq6bi 212 13 128 128 CD cord-018017-c8myq6bi 212 14 amino amino JJ cord-018017-c8myq6bi 212 15 acids acid NNS cord-018017-c8myq6bi 212 16 was be VBD cord-018017-c8myq6bi 212 17 found find VBN cord-018017-c8myq6bi 212 18 to to TO cord-018017-c8myq6bi 212 19 be be VB cord-018017-c8myq6bi 212 20 lost lose VBN cord-018017-c8myq6bi 212 21 or or CC cord-018017-c8myq6bi 212 22 damaged damage VBN cord-018017-c8myq6bi 212 23 in in IN cord-018017-c8myq6bi 212 24 al al NNP cord-018017-c8myq6bi 212 25 XLP XLP NNP cord-018017-c8myq6bi 212 26 patients patient NNS cord-018017-c8myq6bi 212 27 ( ( -LRB- cord-018017-c8myq6bi 212 28 Nichols Nichols NNP cord-018017-c8myq6bi 212 29 et et NNP cord-018017-c8myq6bi 212 30 al al NNP cord-018017-c8myq6bi 212 31 . . NNP cord-018017-c8myq6bi 212 32 1998 1998 CD cord-018017-c8myq6bi 212 33 ) ) -RRB- cord-018017-c8myq6bi 212 34 . . . cord-018017-c8myq6bi 213 1 Curiously curiously RB cord-018017-c8myq6bi 213 2 , , , cord-018017-c8myq6bi 213 3 the the DT cord-018017-c8myq6bi 213 4 XLP XLP NNP cord-018017-c8myq6bi 213 5 protein protein NN cord-018017-c8myq6bi 213 6 loss loss NN cord-018017-c8myq6bi 213 7 leads lead VBZ cord-018017-c8myq6bi 213 8 to to IN cord-018017-c8myq6bi 213 9 a a DT cord-018017-c8myq6bi 213 10 defect defect NN cord-018017-c8myq6bi 213 11 in in IN cord-018017-c8myq6bi 213 12 NK NK NNP cord-018017-c8myq6bi 213 13 and and CC cord-018017-c8myq6bi 213 14 T t NN cord-018017-c8myq6bi 213 15 lymphocytes lymphocyte NNS cord-018017-c8myq6bi 213 16 which which WDT cord-018017-c8myq6bi 213 17 are be VBP cord-018017-c8myq6bi 213 18 necessary necessary JJ cord-018017-c8myq6bi 213 19 for for IN cord-018017-c8myq6bi 213 20 recognition recognition NN cord-018017-c8myq6bi 213 21 of of IN cord-018017-c8myq6bi 213 22 EBV EBV NNP cord-018017-c8myq6bi 213 23 infected infect VBN cord-018017-c8myq6bi 213 24 B b NN cord-018017-c8myq6bi 213 25 lymphocytes lymphocyte NNS cord-018017-c8myq6bi 213 26 . . . cord-018017-c8myq6bi 214 1 These these DT cord-018017-c8myq6bi 214 2 individuals individual NNS cord-018017-c8myq6bi 214 3 can can MD cord-018017-c8myq6bi 214 4 not not RB cord-018017-c8myq6bi 214 5 make make VB cord-018017-c8myq6bi 214 6 antibodies antibody NNS cord-018017-c8myq6bi 214 7 to to IN cord-018017-c8myq6bi 214 8 EBV EBV NNP cord-018017-c8myq6bi 214 9 because because IN cord-018017-c8myq6bi 214 10 their -PRON- PRP$ cord-018017-c8myq6bi 214 11 B b NN cord-018017-c8myq6bi 214 12 cells cell NNS cord-018017-c8myq6bi 214 13 require require VBP cord-018017-c8myq6bi 214 14 help help NN cord-018017-c8myq6bi 214 15 from from IN cord-018017-c8myq6bi 214 16 T t NN cord-018017-c8myq6bi 214 17 lymphocytes lymphocyte NNS cord-018017-c8myq6bi 214 18 . . . cord-018017-c8myq6bi 215 1 The the DT cord-018017-c8myq6bi 215 2 development development NN cord-018017-c8myq6bi 215 3 of of IN cord-018017-c8myq6bi 215 4 potent potent JJ cord-018017-c8myq6bi 215 5 immune immune JJ cord-018017-c8myq6bi 215 6 suppressing suppress VBG cord-018017-c8myq6bi 215 7 drugs drug NNS cord-018017-c8myq6bi 215 8 like like IN cord-018017-c8myq6bi 215 9 cyclosporine cyclosporine NN cord-018017-c8myq6bi 215 10 A A NNP cord-018017-c8myq6bi 215 11 was be VBD cord-018017-c8myq6bi 215 12 linked link VBN cord-018017-c8myq6bi 215 13 to to IN cord-018017-c8myq6bi 215 14 lymphoma lymphoma NN cord-018017-c8myq6bi 215 15 after after IN cord-018017-c8myq6bi 215 16 organ organ NN cord-018017-c8myq6bi 215 17 transplantation transplantation NN cord-018017-c8myq6bi 215 18 . . . cord-018017-c8myq6bi 216 1 Two two CD cord-018017-c8myq6bi 216 2 girls girl NNS cord-018017-c8myq6bi 216 3 with with IN cord-018017-c8myq6bi 216 4 acute acute JJ cord-018017-c8myq6bi 216 5 lymphoblastic lymphoblastic JJ cord-018017-c8myq6bi 216 6 leukemia leukemia NN cord-018017-c8myq6bi 216 7 received receive VBD cord-018017-c8myq6bi 216 8 bone bone NN cord-018017-c8myq6bi 216 9 marrow marrow NN cord-018017-c8myq6bi 216 10 transplants transplant NNS cord-018017-c8myq6bi 216 11 from from IN cord-018017-c8myq6bi 216 12 their -PRON- PRP$ cord-018017-c8myq6bi 216 13 HLA HLA NNP cord-018017-c8myq6bi 216 14 - - HYPH cord-018017-c8myq6bi 216 15 match match NN cord-018017-c8myq6bi 216 16 brothers brother NNS cord-018017-c8myq6bi 216 17 . . . cord-018017-c8myq6bi 217 1 The the DT cord-018017-c8myq6bi 217 2 grafts graft NNS cord-018017-c8myq6bi 217 3 were be VBD cord-018017-c8myq6bi 217 4 successful successful JJ cord-018017-c8myq6bi 217 5 but but CC cord-018017-c8myq6bi 217 6 they -PRON- PRP cord-018017-c8myq6bi 217 7 developed develop VBD cord-018017-c8myq6bi 217 8 lymphoblastic lymphoblastic JJ cord-018017-c8myq6bi 217 9 leukemia leukemia NN cord-018017-c8myq6bi 217 10 from from IN cord-018017-c8myq6bi 217 11 the the DT cord-018017-c8myq6bi 217 12 transplant transplant NN cord-018017-c8myq6bi 217 13 ( ( -LRB- cord-018017-c8myq6bi 217 14 male male JJ cord-018017-c8myq6bi 217 15 cells cell NNS cord-018017-c8myq6bi 217 16 ) ) -RRB- cord-018017-c8myq6bi 217 17 . . . cord-018017-c8myq6bi 218 1 These these DT cord-018017-c8myq6bi 218 2 lymphomas lymphoma NNS cord-018017-c8myq6bi 218 3 do do VBP cord-018017-c8myq6bi 218 4 not not RB cord-018017-c8myq6bi 218 5 present present VB cord-018017-c8myq6bi 218 6 chromosomal chromosomal JJ cord-018017-c8myq6bi 218 7 translocation translocation NN cord-018017-c8myq6bi 218 8 like like IN cord-018017-c8myq6bi 218 9 Burkitt Burkitt NNP cord-018017-c8myq6bi 218 10 lymphomas lymphoma NNS cord-018017-c8myq6bi 218 11 revealing reveal VBG cord-018017-c8myq6bi 218 12 a a DT cord-018017-c8myq6bi 218 13 new new JJ cord-018017-c8myq6bi 218 14 path path NN cord-018017-c8myq6bi 218 15 from from IN cord-018017-c8myq6bi 218 16 EBV EBV NNP cord-018017-c8myq6bi 218 17 to to IN cord-018017-c8myq6bi 218 18 lymphoma lymphoma NN cord-018017-c8myq6bi 218 19 . . . cord-018017-c8myq6bi 219 1 The the DT cord-018017-c8myq6bi 219 2 immune immune JJ cord-018017-c8myq6bi 219 3 suppression suppression NN cord-018017-c8myq6bi 219 4 upsets upset VBZ cord-018017-c8myq6bi 219 5 the the DT cord-018017-c8myq6bi 219 6 EBV EBV NNP cord-018017-c8myq6bi 219 7 host host NN cord-018017-c8myq6bi 219 8 homeostasis homeostasis NN cord-018017-c8myq6bi 219 9 crippling cripple VBG cord-018017-c8myq6bi 219 10 T T NNP cord-018017-c8myq6bi 219 11 - - HYPH cord-018017-c8myq6bi 219 12 cells cell NNS cord-018017-c8myq6bi 219 13 that that WDT cord-018017-c8myq6bi 219 14 are be VBP cord-018017-c8myq6bi 219 15 required require VBN cord-018017-c8myq6bi 219 16 for for IN cord-018017-c8myq6bi 219 17 keeping keep VBG cord-018017-c8myq6bi 219 18 EBV EBV NNP cord-018017-c8myq6bi 219 19 under under IN cord-018017-c8myq6bi 219 20 control control NN cord-018017-c8myq6bi 219 21 . . . cord-018017-c8myq6bi 220 1 Another another DT cord-018017-c8myq6bi 220 2 situation situation NN cord-018017-c8myq6bi 220 3 where where WRB cord-018017-c8myq6bi 220 4 the the DT cord-018017-c8myq6bi 220 5 virus virus NN cord-018017-c8myq6bi 220 6 can can MD cord-018017-c8myq6bi 220 7 replicate replicate VB cord-018017-c8myq6bi 220 8 without without IN cord-018017-c8myq6bi 220 9 control control NN cord-018017-c8myq6bi 220 10 is be VBZ cord-018017-c8myq6bi 220 11 in in IN cord-018017-c8myq6bi 220 12 HIV HIV NNP cord-018017-c8myq6bi 220 13 / / SYM cord-018017-c8myq6bi 220 14 AIDS AIDS NNP cord-018017-c8myq6bi 220 15 patients patient NNS cord-018017-c8myq6bi 220 16 and and CC cord-018017-c8myq6bi 220 17 AIDS AIDS NNP cord-018017-c8myq6bi 220 18 - - HYPH cord-018017-c8myq6bi 220 19 lymphoma lymphoma NN cord-018017-c8myq6bi 221 1 is be VBZ cord-018017-c8myq6bi 221 2 yet yet RB cord-018017-c8myq6bi 222 1 another another DT cord-018017-c8myq6bi 222 2 EBV EBV NNP cord-018017-c8myq6bi 222 3 induced induce VBN cord-018017-c8myq6bi 222 4 casualty casualty NN cord-018017-c8myq6bi 222 5 . . . cord-018017-c8myq6bi 223 1 EBV EBV NNP cord-018017-c8myq6bi 223 2 provides provide VBZ cord-018017-c8myq6bi 223 3 key key JJ cord-018017-c8myq6bi 223 4 insights insight NNS cord-018017-c8myq6bi 223 5 into into IN cord-018017-c8myq6bi 223 6 tumors tumor NNS cord-018017-c8myq6bi 223 7 associated associate VBN cord-018017-c8myq6bi 223 8 with with IN cord-018017-c8myq6bi 223 9 viral viral JJ cord-018017-c8myq6bi 223 10 infections infection NNS cord-018017-c8myq6bi 223 11 . . . cord-018017-c8myq6bi 224 1 First first RB cord-018017-c8myq6bi 224 2 , , , cord-018017-c8myq6bi 224 3 the the DT cord-018017-c8myq6bi 224 4 same same JJ cord-018017-c8myq6bi 224 5 virus virus NN cord-018017-c8myq6bi 224 6 is be VBZ cord-018017-c8myq6bi 224 7 linked link VBN cord-018017-c8myq6bi 224 8 to to IN cord-018017-c8myq6bi 224 9 multiple multiple JJ cord-018017-c8myq6bi 224 10 tumors tumor NNS cord-018017-c8myq6bi 224 11 in in IN cord-018017-c8myq6bi 224 12 different different JJ cord-018017-c8myq6bi 224 13 populations population NNS cord-018017-c8myq6bi 224 14 including include VBG cord-018017-c8myq6bi 224 15 Burkitt Burkitt NNP cord-018017-c8myq6bi 224 16 's 's POS cord-018017-c8myq6bi 224 17 lymphoma lymphoma NN cord-018017-c8myq6bi 224 18 , , , cord-018017-c8myq6bi 224 19 Hodgkin Hodgkin NNP cord-018017-c8myq6bi 224 20 lymphoma lymphoma NN cord-018017-c8myq6bi 224 21 , , , cord-018017-c8myq6bi 224 22 and and CC cord-018017-c8myq6bi 224 23 nasopharyngeal nasopharyngeal JJ cord-018017-c8myq6bi 224 24 carcinoma carcinoma NN cord-018017-c8myq6bi 224 25 . . . cord-018017-c8myq6bi 225 1 Second second RB cord-018017-c8myq6bi 225 2 , , , cord-018017-c8myq6bi 225 3 tumorigenesis tumorigenesis NN cord-018017-c8myq6bi 225 4 involves involve VBZ cord-018017-c8myq6bi 225 5 more more JJR cord-018017-c8myq6bi 225 6 than than IN cord-018017-c8myq6bi 225 7 one one CD cord-018017-c8myq6bi 225 8 mechanistic mechanistic JJ cord-018017-c8myq6bi 225 9 pathway pathway NN cord-018017-c8myq6bi 225 10 but but CC cord-018017-c8myq6bi 225 11 interest interest NN cord-018017-c8myq6bi 225 12 has have VBZ cord-018017-c8myq6bi 225 13 focused focus VBN cord-018017-c8myq6bi 225 14 on on IN cord-018017-c8myq6bi 225 15 the the DT cord-018017-c8myq6bi 225 16 latent latent NN cord-018017-c8myq6bi 225 17 membrane membrane NN cord-018017-c8myq6bi 225 18 protein-1 protein-1 NNP cord-018017-c8myq6bi 225 19 ( ( -LRB- cord-018017-c8myq6bi 225 20 LMP1 LMP1 NNP cord-018017-c8myq6bi 225 21 ) ) -RRB- cord-018017-c8myq6bi 225 22 , , , cord-018017-c8myq6bi 225 23 EBV EBV NNP cord-018017-c8myq6bi 225 24 nuclear nuclear JJ cord-018017-c8myq6bi 225 25 antigen antigen NN cord-018017-c8myq6bi 225 26 1 1 CD cord-018017-c8myq6bi 225 27 ( ( -LRB- cord-018017-c8myq6bi 225 28 EBNA1 EBNA1 NNP cord-018017-c8myq6bi 225 29 ) ) -RRB- cord-018017-c8myq6bi 225 30 , , , cord-018017-c8myq6bi 225 31 and and CC cord-018017-c8myq6bi 225 32 BamH1-A BamH1-A NNP cord-018017-c8myq6bi 225 33 reading read VBG cord-018017-c8myq6bi 225 34 frame-1 frame-1 NNP cord-018017-c8myq6bi 225 35 ( ( -LRB- cord-018017-c8myq6bi 225 36 BARF1 BARF1 NNP cord-018017-c8myq6bi 225 37 ) ) -RRB- cord-018017-c8myq6bi 225 38 genes gene NNS cord-018017-c8myq6bi 225 39 . . . cord-018017-c8myq6bi 226 1 Third third RB cord-018017-c8myq6bi 226 2 , , , cord-018017-c8myq6bi 226 3 dissecting dissect VBG cord-018017-c8myq6bi 226 4 the the DT cord-018017-c8myq6bi 226 5 association association NN cord-018017-c8myq6bi 226 6 between between IN cord-018017-c8myq6bi 226 7 infection infection NN cord-018017-c8myq6bi 226 8 with with IN cord-018017-c8myq6bi 226 9 EBV EBV NNP cord-018017-c8myq6bi 226 10 and and CC cord-018017-c8myq6bi 226 11 cancer cancer NN cord-018017-c8myq6bi 226 12 has have VBZ cord-018017-c8myq6bi 226 13 unfolded unfold VBN cord-018017-c8myq6bi 226 14 over over IN cord-018017-c8myq6bi 226 15 a a DT cord-018017-c8myq6bi 226 16 period period NN cord-018017-c8myq6bi 226 17 of of IN cord-018017-c8myq6bi 226 18 30 30 CD cord-018017-c8myq6bi 226 19 years year NNS cord-018017-c8myq6bi 226 20 and and CC cord-018017-c8myq6bi 226 21 led lead VBD cord-018017-c8myq6bi 226 22 to to IN cord-018017-c8myq6bi 226 23 a a DT cord-018017-c8myq6bi 226 24 greater great JJR cord-018017-c8myq6bi 226 25 understanding understanding NN cord-018017-c8myq6bi 226 26 of of IN cord-018017-c8myq6bi 226 27 cancer cancer NN cord-018017-c8myq6bi 226 28 , , , cord-018017-c8myq6bi 226 29 the the DT cord-018017-c8myq6bi 226 30 immune immune JJ cord-018017-c8myq6bi 226 31 system system NN cord-018017-c8myq6bi 226 32 , , , cord-018017-c8myq6bi 226 33 and and CC cord-018017-c8myq6bi 226 34 methods method NNS cord-018017-c8myq6bi 226 35 for for IN cord-018017-c8myq6bi 226 36 immortalizing immortalize VBG cord-018017-c8myq6bi 226 37 cells cell NNS cord-018017-c8myq6bi 226 38 to to TO cord-018017-c8myq6bi 226 39 study study VB cord-018017-c8myq6bi 226 40 specific specific JJ cord-018017-c8myq6bi 226 41 cell cell NN cord-018017-c8myq6bi 226 42 clonal clonal JJ cord-018017-c8myq6bi 226 43 populations population NNS cord-018017-c8myq6bi 226 44 . . . cord-018017-c8myq6bi 227 1 EBV EBV NNP cord-018017-c8myq6bi 227 2 has have VBZ cord-018017-c8myq6bi 227 3 been be VBN cord-018017-c8myq6bi 227 4 a a DT cord-018017-c8myq6bi 227 5 boon boon NN cord-018017-c8myq6bi 227 6 to to IN cord-018017-c8myq6bi 227 7 scientific scientific JJ cord-018017-c8myq6bi 227 8 research research NN cord-018017-c8myq6bi 227 9 while while IN cord-018017-c8myq6bi 227 10 imposing impose VBG cord-018017-c8myq6bi 227 11 a a DT cord-018017-c8myq6bi 227 12 challenge challenge NN cord-018017-c8myq6bi 227 13 to to IN cord-018017-c8myq6bi 227 14 human human JJ cord-018017-c8myq6bi 227 15 survival survival NN cord-018017-c8myq6bi 227 16 . . . cord-018017-c8myq6bi 228 1 Approximately approximately RB cord-018017-c8myq6bi 228 2 2 2 CD cord-018017-c8myq6bi 228 3 billion billion CD cord-018017-c8myq6bi 228 4 people people NNS cord-018017-c8myq6bi 228 5 have have VBP cord-018017-c8myq6bi 228 6 been be VBN cord-018017-c8myq6bi 228 7 infected infect VBN cord-018017-c8myq6bi 228 8 with with IN cord-018017-c8myq6bi 228 9 HBV HBV NNP cord-018017-c8myq6bi 228 10 and and CC cord-018017-c8myq6bi 228 11 360 360 CD cord-018017-c8myq6bi 228 12 million million CD cord-018017-c8myq6bi 228 13 suffer suffer VBP cord-018017-c8myq6bi 228 14 from from IN cord-018017-c8myq6bi 228 15 chronic chronic JJ cord-018017-c8myq6bi 228 16 infection infection NN cord-018017-c8myq6bi 228 17 . . . cord-018017-c8myq6bi 229 1 Acute acute JJ cord-018017-c8myq6bi 229 2 HBV HBV NNP cord-018017-c8myq6bi 229 3 infections infection NNS cord-018017-c8myq6bi 229 4 are be VBP cord-018017-c8myq6bi 229 5 usually usually RB cord-018017-c8myq6bi 229 6 self self NN cord-018017-c8myq6bi 229 7 - - HYPH cord-018017-c8myq6bi 229 8 limiting limit VBG cord-018017-c8myq6bi 229 9 associated associate VBN cord-018017-c8myq6bi 229 10 with with IN cord-018017-c8myq6bi 229 11 5.2 5.2 CD cord-018017-c8myq6bi 229 12 million million CD cord-018017-c8myq6bi 229 13 cases case NNS cord-018017-c8myq6bi 229 14 a a DT cord-018017-c8myq6bi 229 15 year year NN cord-018017-c8myq6bi 229 16 . . . cord-018017-c8myq6bi 230 1 Chronic chronic JJ cord-018017-c8myq6bi 230 2 HBV HBV NNP cord-018017-c8myq6bi 230 3 infections infection NNS cord-018017-c8myq6bi 230 4 lead lead VBP cord-018017-c8myq6bi 230 5 to to IN cord-018017-c8myq6bi 230 6 complications complication NNS cord-018017-c8myq6bi 230 7 in in IN cord-018017-c8myq6bi 230 8 15 15 CD cord-018017-c8myq6bi 230 9 - - SYM cord-018017-c8myq6bi 230 10 40 40 CD cord-018017-c8myq6bi 230 11 percent percent NN cord-018017-c8myq6bi 230 12 of of IN cord-018017-c8myq6bi 230 13 cases case NNS cord-018017-c8myq6bi 230 14 resulting result VBG cord-018017-c8myq6bi 230 15 in in IN cord-018017-c8myq6bi 230 16 0.5 0.5 CD cord-018017-c8myq6bi 230 17 to to TO cord-018017-c8myq6bi 230 18 1.2 1.2 CD cord-018017-c8myq6bi 230 19 million million CD cord-018017-c8myq6bi 230 20 deaths death NNS cord-018017-c8myq6bi 230 21 each each DT cord-018017-c8myq6bi 230 22 year year NN cord-018017-c8myq6bi 230 23 . . . cord-018017-c8myq6bi 231 1 HB HB NNP cord-018017-c8myq6bi 231 2 V V NNP cord-018017-c8myq6bi 231 3 causes cause VBZ cord-018017-c8myq6bi 231 4 60 60 CD cord-018017-c8myq6bi 231 5 - - SYM cord-018017-c8myq6bi 231 6 80 80 CD cord-018017-c8myq6bi 231 7 percent percent NN cord-018017-c8myq6bi 231 8 of of IN cord-018017-c8myq6bi 231 9 the the DT cord-018017-c8myq6bi 231 10 world world NN cord-018017-c8myq6bi 231 11 HCC HCC NNP cord-018017-c8myq6bi 231 12 cases case NNS cord-018017-c8myq6bi 231 13 which which WDT cord-018017-c8myq6bi 231 14 represents represent VBZ cord-018017-c8myq6bi 231 15 5 5 CD cord-018017-c8myq6bi 231 16 percent percent NN cord-018017-c8myq6bi 231 17 of of IN cord-018017-c8myq6bi 231 18 all all DT cord-018017-c8myq6bi 231 19 cancers cancer NNS cord-018017-c8myq6bi 231 20 in in IN cord-018017-c8myq6bi 231 21 the the DT cord-018017-c8myq6bi 231 22 world world NN cord-018017-c8myq6bi 231 23 . . . cord-018017-c8myq6bi 232 1 The the DT cord-018017-c8myq6bi 232 2 HBx hbx NN cord-018017-c8myq6bi 232 3 gene gene NN cord-018017-c8myq6bi 232 4 is be VBZ cord-018017-c8myq6bi 232 5 considered consider VBN cord-018017-c8myq6bi 232 6 key key JJ cord-018017-c8myq6bi 232 7 to to IN cord-018017-c8myq6bi 232 8 oncogenesis oncogenesis NNP cord-018017-c8myq6bi 232 9 . . . cord-018017-c8myq6bi 233 1 Vaccination vaccination NN cord-018017-c8myq6bi 233 2 programs program NNS cord-018017-c8myq6bi 233 3 are be VBP cord-018017-c8myq6bi 233 4 effective effective JJ cord-018017-c8myq6bi 233 5 in in IN cord-018017-c8myq6bi 233 6 reducing reduce VBG cord-018017-c8myq6bi 233 7 mortality mortality NN cord-018017-c8myq6bi 233 8 in in IN cord-018017-c8myq6bi 233 9 infants infant NNS cord-018017-c8myq6bi 233 10 and and CC cord-018017-c8myq6bi 233 11 have have VBP cord-018017-c8myq6bi 233 12 reduced reduce VBN cord-018017-c8myq6bi 233 13 emerging emerge VBG cord-018017-c8myq6bi 233 14 prevalence prevalence NN cord-018017-c8myq6bi 233 15 of of IN cord-018017-c8myq6bi 233 16 the the DT cord-018017-c8myq6bi 233 17 disease disease NN cord-018017-c8myq6bi 233 18 . . . cord-018017-c8myq6bi 234 1 Dietary dietary JJ cord-018017-c8myq6bi 234 2 exposure exposure NN cord-018017-c8myq6bi 234 3 to to IN cord-018017-c8myq6bi 234 4 aflatoxin aflatoxin NN cord-018017-c8myq6bi 234 5 enhances enhance VBZ cord-018017-c8myq6bi 234 6 HBVrelated hbvrelate VBN cord-018017-c8myq6bi 234 7 HCC HCC NNP cord-018017-c8myq6bi 234 8 ( ( -LRB- cord-018017-c8myq6bi 234 9 Sun Sun NNP cord-018017-c8myq6bi 234 10 et et FW cord-018017-c8myq6bi 234 11 al al NNP cord-018017-c8myq6bi 234 12 . . . cord-018017-c8myq6bi 234 13 1999 1999 CD cord-018017-c8myq6bi 234 14 ) ) -RRB- cord-018017-c8myq6bi 234 15 as as RB cord-018017-c8myq6bi 234 16 well well RB cord-018017-c8myq6bi 234 17 as as IN cord-018017-c8myq6bi 234 18 co co NN cord-018017-c8myq6bi 234 19 - - NN cord-018017-c8myq6bi 234 20 infection infection NN cord-018017-c8myq6bi 234 21 with with IN cord-018017-c8myq6bi 234 22 HCV HCV NNP cord-018017-c8myq6bi 234 23 and and CC cord-018017-c8myq6bi 234 24 excessive excessive JJ cord-018017-c8myq6bi 234 25 alcohol alcohol NN cord-018017-c8myq6bi 234 26 consumption consumption NN cord-018017-c8myq6bi 234 27 . . . cord-018017-c8myq6bi 235 1 Hepatitis Hepatitis NNP cord-018017-c8myq6bi 235 2 B B NNP cord-018017-c8myq6bi 235 3 Virus Virus NNP cord-018017-c8myq6bi 235 4 ( ( -LRB- cord-018017-c8myq6bi 235 5 HBV HBV NNP cord-018017-c8myq6bi 235 6 ) ) -RRB- cord-018017-c8myq6bi 235 7 was be VBD cord-018017-c8myq6bi 235 8 named name VBN cord-018017-c8myq6bi 235 9 due due IN cord-018017-c8myq6bi 235 10 to to IN cord-018017-c8myq6bi 235 11 differences difference NNS cord-018017-c8myq6bi 235 12 in in IN cord-018017-c8myq6bi 235 13 transmission transmission NN cord-018017-c8myq6bi 235 14 : : : cord-018017-c8myq6bi 235 15 hepatitis hepatitis NNP cord-018017-c8myq6bi 235 16 A a DT cord-018017-c8myq6bi 235 17 type type NN cord-018017-c8myq6bi 235 18 virus virus NN cord-018017-c8myq6bi 235 19 follows follow VBZ cord-018017-c8myq6bi 235 20 fecal fecal JJ cord-018017-c8myq6bi 235 21 - - HYPH cord-018017-c8myq6bi 235 22 oral oral JJ cord-018017-c8myq6bi 235 23 transmission transmission NN cord-018017-c8myq6bi 235 24 while while IN cord-018017-c8myq6bi 235 25 B b NN cord-018017-c8myq6bi 235 26 type type NN cord-018017-c8myq6bi 235 27 virus virus NN cord-018017-c8myq6bi 235 28 is be VBZ cord-018017-c8myq6bi 235 29 parenteral parenteral JJ cord-018017-c8myq6bi 235 30 . . . cord-018017-c8myq6bi 236 1 The the DT cord-018017-c8myq6bi 236 2 genome genome NN cord-018017-c8myq6bi 236 3 is be VBZ cord-018017-c8myq6bi 236 4 circular circular JJ cord-018017-c8myq6bi 236 5 DNA dna NN cord-018017-c8myq6bi 236 6 that that WDT cord-018017-c8myq6bi 236 7 is be VBZ cord-018017-c8myq6bi 236 8 not not RB cord-018017-c8myq6bi 236 9 fully fully RB cord-018017-c8myq6bi 236 10 double double RB cord-018017-c8myq6bi 236 11 - - HYPH cord-018017-c8myq6bi 236 12 stranded strand VBN cord-018017-c8myq6bi 236 13 with with IN cord-018017-c8myq6bi 236 14 the the DT cord-018017-c8myq6bi 236 15 end end NN cord-018017-c8myq6bi 236 16 of of IN cord-018017-c8myq6bi 236 17 the the DT cord-018017-c8myq6bi 236 18 fulllength fulllength NN cord-018017-c8myq6bi 236 19 strand strand NN cord-018017-c8myq6bi 236 20 linked link VBN cord-018017-c8myq6bi 236 21 to to IN cord-018017-c8myq6bi 236 22 DNA dna NN cord-018017-c8myq6bi 236 23 polymerase polymerase NN cord-018017-c8myq6bi 236 24 . . . cord-018017-c8myq6bi 237 1 The the DT cord-018017-c8myq6bi 237 2 genome genome NN cord-018017-c8myq6bi 237 3 is be VBZ cord-018017-c8myq6bi 237 4 3020 3020 CD cord-018017-c8myq6bi 237 5 - - SYM cord-018017-c8myq6bi 237 6 3320 3320 CD cord-018017-c8myq6bi 237 7 nucleotides nucleotide NNS cord-018017-c8myq6bi 237 8 long long JJ cord-018017-c8myq6bi 237 9 ( ( -LRB- cord-018017-c8myq6bi 237 10 full full JJ cord-018017-c8myq6bi 237 11 length length NN cord-018017-c8myq6bi 237 12 strand strand NN cord-018017-c8myq6bi 237 13 ) ) -RRB- cord-018017-c8myq6bi 237 14 and and CC cord-018017-c8myq6bi 237 15 1700 1700 CD cord-018017-c8myq6bi 237 16 - - SYM cord-018017-c8myq6bi 237 17 2800 2800 CD cord-018017-c8myq6bi 237 18 nucleotides nucleotide NNS cord-018017-c8myq6bi 237 19 for for IN cord-018017-c8myq6bi 237 20 the the DT cord-018017-c8myq6bi 237 21 short short JJ cord-018017-c8myq6bi 237 22 strand strand NN cord-018017-c8myq6bi 237 23 . . . cord-018017-c8myq6bi 238 1 Four four CD cord-018017-c8myq6bi 238 2 genes gene NNS cord-018017-c8myq6bi 238 3 are be VBP cord-018017-c8myq6bi 238 4 encoded encode VBN cord-018017-c8myq6bi 238 5 including include VBG cord-018017-c8myq6bi 238 6 : : : cord-018017-c8myq6bi 238 7 ( ( -LRB- cord-018017-c8myq6bi 238 8 1 1 LS cord-018017-c8myq6bi 238 9 ) ) -RRB- cord-018017-c8myq6bi 238 10 C C NNP cord-018017-c8myq6bi 238 11 the the DT cord-018017-c8myq6bi 238 12 core core NN cord-018017-c8myq6bi 238 13 protein protein NN cord-018017-c8myq6bi 238 14 ( ( -LRB- cord-018017-c8myq6bi 238 15 HBcAg hbcag CD cord-018017-c8myq6bi 238 16 ) ) -RRB- cord-018017-c8myq6bi 238 17 synthesized synthesize VBN cord-018017-c8myq6bi 238 18 by by IN cord-018017-c8myq6bi 238 19 uORF uorf JJ cord-018017-c8myq6bi 238 20 AUG AUG NNP cord-018017-c8myq6bi 238 21 to to TO cord-018017-c8myq6bi 238 22 make make VB cord-018017-c8myq6bi 238 23 pre pre JJ cord-018017-c8myq6bi 238 24 - - JJ cord-018017-c8myq6bi 238 25 core core JJ cord-018017-c8myq6bi 238 26 protein protein NN cord-018017-c8myq6bi 238 27 , , . cord-018017-c8myq6bi 239 1 ( ( -LRB- cord-018017-c8myq6bi 239 2 2 2 LS cord-018017-c8myq6bi 239 3 ) ) -RRB- cord-018017-c8myq6bi 239 4 P p NN cord-018017-c8myq6bi 239 5 is be VBZ cord-018017-c8myq6bi 239 6 the the DT cord-018017-c8myq6bi 239 7 DNA dna NN cord-018017-c8myq6bi 239 8 polymerase polymerase NN cord-018017-c8myq6bi 239 9 , , , cord-018017-c8myq6bi 239 10 ( ( -LRB- cord-018017-c8myq6bi 239 11 3 3 LS cord-018017-c8myq6bi 239 12 ) ) -RRB- cord-018017-c8myq6bi 239 13 S S NNP cord-018017-c8myq6bi 239 14 is be VBZ cord-018017-c8myq6bi 239 15 the the DT cord-018017-c8myq6bi 239 16 surface surface NN cord-018017-c8myq6bi 239 17 antigen antigen NN cord-018017-c8myq6bi 239 18 ( ( -LRB- cord-018017-c8myq6bi 239 19 HBsAg HBsAg NNP cord-018017-c8myq6bi 239 20 ) ) -RRB- cord-018017-c8myq6bi 239 21 which which WDT cord-018017-c8myq6bi 239 22 has have VBZ cord-018017-c8myq6bi 239 23 three three CD cord-018017-c8myq6bi 239 24 AUG AUG NNP cord-018017-c8myq6bi 239 25 start start NN cord-018017-c8myq6bi 239 26 sites site NNS cord-018017-c8myq6bi 239 27 that that WDT cord-018017-c8myq6bi 239 28 divide divide VBP cord-018017-c8myq6bi 239 29 the the DT cord-018017-c8myq6bi 239 30 gene gene NN cord-018017-c8myq6bi 239 31 into into IN cord-018017-c8myq6bi 239 32 pre pre JJ cord-018017-c8myq6bi 239 33 - - JJ cord-018017-c8myq6bi 239 34 S1 s1 JJ cord-018017-c8myq6bi 239 35 , , , cord-018017-c8myq6bi 239 36 pre pre JJ cord-018017-c8myq6bi 239 37 - - JJ cord-018017-c8myq6bi 239 38 S2 S2 NNP cord-018017-c8myq6bi 239 39 , , , cord-018017-c8myq6bi 239 40 and and CC cord-018017-c8myq6bi 239 41 S S NNP cord-018017-c8myq6bi 239 42 , , , cord-018017-c8myq6bi 239 43 and and CC cord-018017-c8myq6bi 239 44 ( ( -LRB- cord-018017-c8myq6bi 239 45 4 4 LS cord-018017-c8myq6bi 239 46 ) ) -RRB- cord-018017-c8myq6bi 240 1 X X NNP cord-018017-c8myq6bi 240 2 is be VBZ cord-018017-c8myq6bi 240 3 a a DT cord-018017-c8myq6bi 240 4 gene gene NN cord-018017-c8myq6bi 240 5 that that WDT cord-018017-c8myq6bi 240 6 is be VBZ cord-018017-c8myq6bi 240 7 not not RB cord-018017-c8myq6bi 240 8 fully fully RB cord-018017-c8myq6bi 240 9 understood understand VBN cord-018017-c8myq6bi 240 10 but but CC cord-018017-c8myq6bi 240 11 may may MD cord-018017-c8myq6bi 240 12 be be VB cord-018017-c8myq6bi 240 13 a a DT cord-018017-c8myq6bi 240 14 transcriptional transcriptional JJ cord-018017-c8myq6bi 240 15 transactivator transactivator NN cord-018017-c8myq6bi 240 16 . . . cord-018017-c8myq6bi 241 1 Non non JJ cord-018017-c8myq6bi 241 2 - - JJ cord-018017-c8myq6bi 241 3 coding code VBG cord-018017-c8myq6bi 241 4 RNA RNA NNP cord-018017-c8myq6bi 241 5 include include VBP cord-018017-c8myq6bi 241 6 HBV HBV NNP cord-018017-c8myq6bi 241 7 PREalpha PREalpha NNP cord-018017-c8myq6bi 241 8 , , , cord-018017-c8myq6bi 241 9 HBV HBV NNP cord-018017-c8myq6bi 241 10 PREbeta PREbeta NNP cord-018017-c8myq6bi 241 11 , , , cord-018017-c8myq6bi 241 12 and and CC cord-018017-c8myq6bi 241 13 HBV HBV NNP cord-018017-c8myq6bi 241 14 RNA RNA NNP cord-018017-c8myq6bi 241 15 encapsidation encapsidation NN cord-018017-c8myq6bi 241 16 signal signal NN cord-018017-c8myq6bi 241 17 epsilon epsilon NN cord-018017-c8myq6bi 241 18 . . . cord-018017-c8myq6bi 242 1 There there EX cord-018017-c8myq6bi 242 2 are be VBP cord-018017-c8myq6bi 242 3 10 10 CD cord-018017-c8myq6bi 242 4 known know VBN cord-018017-c8myq6bi 242 5 genotypes genotype NNS cord-018017-c8myq6bi 242 6 which which WDT cord-018017-c8myq6bi 242 7 differ differ VBP cord-018017-c8myq6bi 242 8 by by IN cord-018017-c8myq6bi 242 9 8 8 CD cord-018017-c8myq6bi 242 10 percent percent NN cord-018017-c8myq6bi 242 11 in in IN cord-018017-c8myq6bi 242 12 sequence sequence NN cord-018017-c8myq6bi 242 13 with with IN cord-018017-c8myq6bi 242 14 distinct distinct JJ cord-018017-c8myq6bi 242 15 geographical geographical JJ cord-018017-c8myq6bi 242 16 distributions distribution NNS cord-018017-c8myq6bi 242 17 and and CC cord-018017-c8myq6bi 242 18 are be VBP cord-018017-c8myq6bi 242 19 labeled label VBN cord-018017-c8myq6bi 242 20 A a NN cord-018017-c8myq6bi 242 21 to to IN cord-018017-c8myq6bi 242 22 J J NNP cord-018017-c8myq6bi 242 23 and and CC cord-018017-c8myq6bi 242 24 at at IN cord-018017-c8myq6bi 242 25 least least JJS cord-018017-c8myq6bi 242 26 24 24 CD cord-018017-c8myq6bi 242 27 subtypes subtype NNS cord-018017-c8myq6bi 242 28 . . . cord-018017-c8myq6bi 243 1 Type Type NNP cord-018017-c8myq6bi 243 2 F F NNP cord-018017-c8myq6bi 243 3 is be VBZ cord-018017-c8myq6bi 243 4 the the DT cord-018017-c8myq6bi 243 5 most most RBS cord-018017-c8myq6bi 243 6 divergent divergent JJ cord-018017-c8myq6bi 243 7 form form NN cord-018017-c8myq6bi 243 8 and and CC cord-018017-c8myq6bi 243 9 found find VBN cord-018017-c8myq6bi 243 10 in in IN cord-018017-c8myq6bi 243 11 Central Central NNP cord-018017-c8myq6bi 243 12 and and CC cord-018017-c8myq6bi 243 13 South South NNP cord-018017-c8myq6bi 243 14 America America NNP cord-018017-c8myq6bi 243 15 , , , cord-018017-c8myq6bi 243 16 predominantly predominantly RB cord-018017-c8myq6bi 243 17 Brazil Brazil NNP cord-018017-c8myq6bi 243 18 . . . cord-018017-c8myq6bi 244 1 Human Human NNP cord-018017-c8myq6bi 244 2 HBV HBV NNP cord-018017-c8myq6bi 244 3 has have VBZ cord-018017-c8myq6bi 244 4 a a DT cord-018017-c8myq6bi 244 5 narrow narrow JJ cord-018017-c8myq6bi 244 6 host host NN cord-018017-c8myq6bi 244 7 range range NN cord-018017-c8myq6bi 244 8 infecting infect VBG cord-018017-c8myq6bi 244 9 humans human NNS cord-018017-c8myq6bi 244 10 and and CC cord-018017-c8myq6bi 244 11 higher high JJR cord-018017-c8myq6bi 244 12 primates primate NNS cord-018017-c8myq6bi 244 13 , , , cord-018017-c8myq6bi 244 14 eg eg IN cord-018017-c8myq6bi 244 15 . . . cord-018017-c8myq6bi 245 1 Chimpanzees chimpanzee NNS cord-018017-c8myq6bi 245 2 . . . cord-018017-c8myq6bi 246 1 In in IN cord-018017-c8myq6bi 246 2 the the DT cord-018017-c8myq6bi 246 3 1970s 1970 NNS cord-018017-c8myq6bi 246 4 a a DT cord-018017-c8myq6bi 246 5 Woodchuck Woodchuck NNP cord-018017-c8myq6bi 246 6 hepatitis hepatitis NN cord-018017-c8myq6bi 246 7 virus virus NN cord-018017-c8myq6bi 246 8 ( ( -LRB- cord-018017-c8myq6bi 246 9 WHV WHV NNP cord-018017-c8myq6bi 246 10 ) ) -RRB- cord-018017-c8myq6bi 246 11 was be VBD cord-018017-c8myq6bi 246 12 discovered discover VBN cord-018017-c8myq6bi 246 13 which which WDT cord-018017-c8myq6bi 246 14 will will MD cord-018017-c8myq6bi 246 15 not not RB cord-018017-c8myq6bi 246 16 infect infect VB cord-018017-c8myq6bi 246 17 rodents rodent NNS cord-018017-c8myq6bi 246 18 . . . cord-018017-c8myq6bi 247 1 A a DT cord-018017-c8myq6bi 247 2 ground ground NN cord-018017-c8myq6bi 247 3 squirrel squirrel NN cord-018017-c8myq6bi 247 4 form form NN cord-018017-c8myq6bi 247 5 was be VBD cord-018017-c8myq6bi 247 6 identified identify VBN cord-018017-c8myq6bi 247 7 ( ( -LRB- cord-018017-c8myq6bi 247 8 GSHV GSHV NNP cord-018017-c8myq6bi 247 9 ) ) -RRB- cord-018017-c8myq6bi 247 10 that that DT cord-018017-c8myq6bi 247 11 is be VBZ cord-018017-c8myq6bi 247 12 a a DT cord-018017-c8myq6bi 247 13 distant distant JJ cord-018017-c8myq6bi 247 14 relative relative NN cord-018017-c8myq6bi 247 15 of of IN cord-018017-c8myq6bi 247 16 the the DT cord-018017-c8myq6bi 247 17 marmot marmot NN cord-018017-c8myq6bi 247 18 and and CC cord-018017-c8myq6bi 247 19 woodchuck woodchuck NN cord-018017-c8myq6bi 247 20 . . . cord-018017-c8myq6bi 248 1 Indeed indeed RB cord-018017-c8myq6bi 248 2 , , , cord-018017-c8myq6bi 248 3 DHBV DHBV NNP cord-018017-c8myq6bi 248 4 infects infect VBZ cord-018017-c8myq6bi 248 5 ducks duck NNS cord-018017-c8myq6bi 248 6 but but CC cord-018017-c8myq6bi 248 7 not not RB cord-018017-c8myq6bi 248 8 all all DT cord-018017-c8myq6bi 248 9 species specie NNS cord-018017-c8myq6bi 248 10 of of IN cord-018017-c8myq6bi 248 11 duck duck NN cord-018017-c8myq6bi 248 12 , , , cord-018017-c8myq6bi 248 13 grey grey NNP cord-018017-c8myq6bi 248 14 herons heron NNS cord-018017-c8myq6bi 248 15 are be VBP cord-018017-c8myq6bi 248 16 infected infect VBN cord-018017-c8myq6bi 248 17 with with IN cord-018017-c8myq6bi 248 18 HHBV HHBV NNP cord-018017-c8myq6bi 248 19 , , , cord-018017-c8myq6bi 248 20 the the DT cord-018017-c8myq6bi 248 21 Ross Ross NNP cord-018017-c8myq6bi 248 22 ' ' POS cord-018017-c8myq6bi 248 23 goose goose NN cord-018017-c8myq6bi 248 24 with with IN cord-018017-c8myq6bi 248 25 RGHBV RGHBV NNP cord-018017-c8myq6bi 248 26 , , , cord-018017-c8myq6bi 248 27 the the DT cord-018017-c8myq6bi 248 28 snow snow NN cord-018017-c8myq6bi 248 29 goose goose NN cord-018017-c8myq6bi 248 30 with with IN cord-018017-c8myq6bi 248 31 SGHBV SGHBV NNP cord-018017-c8myq6bi 248 32 , , , cord-018017-c8myq6bi 248 33 white white JJ cord-018017-c8myq6bi 248 34 storks stork NNS cord-018017-c8myq6bi 248 35 with with IN cord-018017-c8myq6bi 248 36 STHBV STHBV NNP cord-018017-c8myq6bi 248 37 , , , cord-018017-c8myq6bi 248 38 and and CC cord-018017-c8myq6bi 248 39 cranes crane NNS cord-018017-c8myq6bi 248 40 with with IN cord-018017-c8myq6bi 248 41 CHBV CHBV NNS cord-018017-c8myq6bi 248 42 . . . cord-018017-c8myq6bi 249 1 There there EX cord-018017-c8myq6bi 249 2 are be VBP cord-018017-c8myq6bi 249 3 no no DT cord-018017-c8myq6bi 249 4 hepadnaviruses hepadnavirus NNS cord-018017-c8myq6bi 249 5 in in IN cord-018017-c8myq6bi 249 6 arthropods arthropod NNS cord-018017-c8myq6bi 249 7 or or CC cord-018017-c8myq6bi 249 8 insects insect NNS cord-018017-c8myq6bi 249 9 . . . cord-018017-c8myq6bi 250 1 Human Human NNP cord-018017-c8myq6bi 250 2 T t NN cord-018017-c8myq6bi 250 3 - - HYPH cord-018017-c8myq6bi 250 4 cell cell NN cord-018017-c8myq6bi 250 5 Lymphotropic Lymphotropic NNP cord-018017-c8myq6bi 250 6 Virus Virus NNP cord-018017-c8myq6bi 250 7 ( ( -LRB- cord-018017-c8myq6bi 250 8 HTLV-1 HTLV-1 NNP cord-018017-c8myq6bi 250 9 ) ) -RRB- cord-018017-c8myq6bi 250 10 HTLV-1 HTLV-1 NNP cord-018017-c8myq6bi 250 11 is be VBZ cord-018017-c8myq6bi 250 12 a a DT cord-018017-c8myq6bi 250 13 single single RB cord-018017-c8myq6bi 250 14 - - HYPH cord-018017-c8myq6bi 250 15 stranded strand VBN cord-018017-c8myq6bi 250 16 RNA RNA NNP cord-018017-c8myq6bi 250 17 retrovirus retrovirus NN cord-018017-c8myq6bi 250 18 , , , cord-018017-c8myq6bi 250 19 defined define VBN cord-018017-c8myq6bi 250 20 by by IN cord-018017-c8myq6bi 250 21 their -PRON- PRP$ cord-018017-c8myq6bi 250 22 use use NN cord-018017-c8myq6bi 250 23 of of IN cord-018017-c8myq6bi 250 24 reverse reverse JJ cord-018017-c8myq6bi 250 25 transcriptase transcriptase NN cord-018017-c8myq6bi 250 26 , , , cord-018017-c8myq6bi 250 27 a a DT cord-018017-c8myq6bi 250 28 polymerase polymerase NN cord-018017-c8myq6bi 250 29 , , , cord-018017-c8myq6bi 250 30 that that WDT cord-018017-c8myq6bi 250 31 makes make VBZ cord-018017-c8myq6bi 250 32 a a DT cord-018017-c8myq6bi 250 33 DNA dna NN cord-018017-c8myq6bi 250 34 copy copy NN cord-018017-c8myq6bi 250 35 of of IN cord-018017-c8myq6bi 250 36 the the DT cord-018017-c8myq6bi 250 37 RNA RNA NNP cord-018017-c8myq6bi 250 38 7 7 CD cord-018017-c8myq6bi 250 39 kb kb NNP cord-018017-c8myq6bi 250 40 viral viral JJ cord-018017-c8myq6bi 250 41 genome genome NN cord-018017-c8myq6bi 250 42 . . . cord-018017-c8myq6bi 251 1 The the DT cord-018017-c8myq6bi 251 2 DNA dna NN cord-018017-c8myq6bi 251 3 viral viral JJ cord-018017-c8myq6bi 251 4 genome genome NN cord-018017-c8myq6bi 251 5 is be VBZ cord-018017-c8myq6bi 251 6 integrated integrate VBN cord-018017-c8myq6bi 251 7 into into IN cord-018017-c8myq6bi 251 8 the the DT cord-018017-c8myq6bi 251 9 host host NN cord-018017-c8myq6bi 251 10 genome genome NN cord-018017-c8myq6bi 251 11 where where WRB cord-018017-c8myq6bi 251 12 it -PRON- PRP cord-018017-c8myq6bi 251 13 is be VBZ cord-018017-c8myq6bi 251 14 referred refer VBN cord-018017-c8myq6bi 251 15 to to IN cord-018017-c8myq6bi 251 16 as as IN cord-018017-c8myq6bi 251 17 a a DT cord-018017-c8myq6bi 251 18 provirus provirus NN cord-018017-c8myq6bi 251 19 and and CC cord-018017-c8myq6bi 251 20 is be VBZ cord-018017-c8myq6bi 251 21 replicated replicate VBN cord-018017-c8myq6bi 251 22 along along IN cord-018017-c8myq6bi 251 23 with with IN cord-018017-c8myq6bi 251 24 the the DT cord-018017-c8myq6bi 251 25 host host NN cord-018017-c8myq6bi 251 26 genome genome NN cord-018017-c8myq6bi 251 27 during during IN cord-018017-c8myq6bi 251 28 cell cell NN cord-018017-c8myq6bi 251 29 division division NN cord-018017-c8myq6bi 251 30 . . . cord-018017-c8myq6bi 252 1 Only only RB cord-018017-c8myq6bi 252 2 1 1 CD cord-018017-c8myq6bi 252 3 percent percent NN cord-018017-c8myq6bi 252 4 of of IN cord-018017-c8myq6bi 252 5 infected infected JJ cord-018017-c8myq6bi 252 6 individuals individual NNS cord-018017-c8myq6bi 252 7 will will MD cord-018017-c8myq6bi 252 8 develop develop VB cord-018017-c8myq6bi 252 9 leukemia leukemia NN cord-018017-c8myq6bi 252 10 and and CC cord-018017-c8myq6bi 252 11 this this DT cord-018017-c8myq6bi 252 12 is be VBZ cord-018017-c8myq6bi 252 13 observed observe VBN cord-018017-c8myq6bi 252 14 20 20 CD cord-018017-c8myq6bi 252 15 to to TO cord-018017-c8myq6bi 252 16 30 30 CD cord-018017-c8myq6bi 252 17 years year NNS cord-018017-c8myq6bi 252 18 after after IN cord-018017-c8myq6bi 252 19 asymptomatic asymptomatic JJ cord-018017-c8myq6bi 252 20 infection infection NN cord-018017-c8myq6bi 252 21 . . . cord-018017-c8myq6bi 253 1 The the DT cord-018017-c8myq6bi 253 2 HTLV-1 HTLV-1 NNP cord-018017-c8myq6bi 253 3 tax tax NN cord-018017-c8myq6bi 253 4 protein protein NN cord-018017-c8myq6bi 253 5 is be VBZ cord-018017-c8myq6bi 253 6 likely likely JJ cord-018017-c8myq6bi 253 7 to to TO cord-018017-c8myq6bi 253 8 initiate initiate VB cord-018017-c8myq6bi 253 9 cell cell NN cord-018017-c8myq6bi 253 10 transformation transformation NN cord-018017-c8myq6bi 253 11 through through IN cord-018017-c8myq6bi 253 12 interactions interaction NNS cord-018017-c8myq6bi 253 13 with with IN cord-018017-c8myq6bi 253 14 transcription transcription NN cord-018017-c8myq6bi 253 15 activators activator NNS cord-018017-c8myq6bi 253 16 and and CC cord-018017-c8myq6bi 253 17 cell cell NN cord-018017-c8myq6bi 253 18 cycle cycle NN cord-018017-c8myq6bi 253 19 regulators regulator NNS cord-018017-c8myq6bi 253 20 . . . cord-018017-c8myq6bi 254 1 Hepatitis Hepatitis NNP cord-018017-c8myq6bi 254 2 C C NNP cord-018017-c8myq6bi 254 3 Virus virus NN cord-018017-c8myq6bi 254 4 ( ( -LRB- cord-018017-c8myq6bi 254 5 HCV HCV NNP cord-018017-c8myq6bi 254 6 ) ) -RRB- cord-018017-c8myq6bi 254 7 HCV HCV NNP cord-018017-c8myq6bi 254 8 has have VBZ cord-018017-c8myq6bi 254 9 infected infect VBN cord-018017-c8myq6bi 254 10 approximately approximately RB cord-018017-c8myq6bi 254 11 3 3 CD cord-018017-c8myq6bi 254 12 percent percent NN cord-018017-c8myq6bi 254 13 of of IN cord-018017-c8myq6bi 254 14 the the DT cord-018017-c8myq6bi 254 15 world world NN cord-018017-c8myq6bi 254 16 's 's POS cord-018017-c8myq6bi 254 17 population population NN cord-018017-c8myq6bi 254 18 ( ( -LRB- cord-018017-c8myq6bi 254 19 ~210 ~210 NNP cord-018017-c8myq6bi 254 20 million million CD cord-018017-c8myq6bi 254 21 ) ) -RRB- cord-018017-c8myq6bi 254 22 but but CC cord-018017-c8myq6bi 254 23 screening screening NN cord-018017-c8myq6bi 254 24 of of IN cord-018017-c8myq6bi 254 25 the the DT cord-018017-c8myq6bi 254 26 blood blood NN cord-018017-c8myq6bi 254 27 supply supply NN cord-018017-c8myq6bi 254 28 has have VBZ cord-018017-c8myq6bi 254 29 reduced reduce VBN cord-018017-c8myq6bi 254 30 prevalence prevalence NN cord-018017-c8myq6bi 254 31 . . . cord-018017-c8myq6bi 255 1 HCV HCV NNP cord-018017-c8myq6bi 255 2 is be VBZ cord-018017-c8myq6bi 255 3 a a DT cord-018017-c8myq6bi 255 4 flavivirus flavivirus NN cord-018017-c8myq6bi 255 5 composed compose VBN cord-018017-c8myq6bi 255 6 of of IN cord-018017-c8myq6bi 255 7 a a DT cord-018017-c8myq6bi 255 8 9.4 9.4 CD cord-018017-c8myq6bi 255 9 kb kb NNP cord-018017-c8myq6bi 255 10 single single RB cord-018017-c8myq6bi 255 11 - - HYPH cord-018017-c8myq6bi 255 12 stranded stranded JJ cord-018017-c8myq6bi 255 13 , , , cord-018017-c8myq6bi 255 14 positivesense positivesense NNP cord-018017-c8myq6bi 255 15 RNA RNA NNP cord-018017-c8myq6bi 255 16 . . . cord-018017-c8myq6bi 256 1 HCV HCV NNP cord-018017-c8myq6bi 256 2 is be VBZ cord-018017-c8myq6bi 256 3 characterized characterize VBN cord-018017-c8myq6bi 256 4 by by IN cord-018017-c8myq6bi 256 5 a a DT cord-018017-c8myq6bi 256 6 single single JJ cord-018017-c8myq6bi 256 7 serotype serotype NN cord-018017-c8myq6bi 256 8 but but CC cord-018017-c8myq6bi 256 9 at at RB cord-018017-c8myq6bi 256 10 least least JJS cord-018017-c8myq6bi 256 11 6 6 CD cord-018017-c8myq6bi 256 12 major major JJ cord-018017-c8myq6bi 256 13 genotypes genotype NNS cord-018017-c8myq6bi 256 14 . . . cord-018017-c8myq6bi 257 1 Genotype genotype NN cord-018017-c8myq6bi 257 2 1b 1b CD cord-018017-c8myq6bi 257 3 is be VBZ cord-018017-c8myq6bi 257 4 the the DT cord-018017-c8myq6bi 257 5 most most RBS cord-018017-c8myq6bi 257 6 common common JJ cord-018017-c8myq6bi 257 7 genotype genotype NN cord-018017-c8myq6bi 257 8 seen see VBN cord-018017-c8myq6bi 257 9 in in IN cord-018017-c8myq6bi 257 10 the the DT cord-018017-c8myq6bi 257 11 United United NNP cord-018017-c8myq6bi 257 12 States States NNP cord-018017-c8myq6bi 257 13 and and CC cord-018017-c8myq6bi 257 14 Taiwan Taiwan NNP cord-018017-c8myq6bi 257 15 . . . cord-018017-c8myq6bi 258 1 HCV HCV NNP cord-018017-c8myq6bi 258 2 becomes become VBZ cord-018017-c8myq6bi 258 3 a a DT cord-018017-c8myq6bi 258 4 chronic chronic JJ cord-018017-c8myq6bi 258 5 infection infection NN cord-018017-c8myq6bi 258 6 by by IN cord-018017-c8myq6bi 258 7 evading evade VBG cord-018017-c8myq6bi 258 8 host host NN cord-018017-c8myq6bi 258 9 immune immune JJ cord-018017-c8myq6bi 258 10 defenses defense NNS cord-018017-c8myq6bi 258 11 through through IN cord-018017-c8myq6bi 258 12 a a DT cord-018017-c8myq6bi 258 13 combination combination NN cord-018017-c8myq6bi 258 14 of of IN cord-018017-c8myq6bi 258 15 : : : cord-018017-c8myq6bi 258 16 ( ( -LRB- cord-018017-c8myq6bi 258 17 1 1 LS cord-018017-c8myq6bi 258 18 ) ) -RRB- cord-018017-c8myq6bi 258 19 high high JJ cord-018017-c8myq6bi 258 20 replication replication NN cord-018017-c8myq6bi 258 21 rate rate NN cord-018017-c8myq6bi 258 22 ( ( -LRB- cord-018017-c8myq6bi 258 23 10 10 CD cord-018017-c8myq6bi 258 24 12 12 CD cord-018017-c8myq6bi 258 25 virions virion NNS cord-018017-c8myq6bi 258 26 / / SYM cord-018017-c8myq6bi 258 27 day day NN cord-018017-c8myq6bi 258 28 ) ) -RRB- cord-018017-c8myq6bi 258 29 and and CC cord-018017-c8myq6bi 258 30 ( ( -LRB- cord-018017-c8myq6bi 258 31 2 2 LS cord-018017-c8myq6bi 258 32 ) ) -RRB- cord-018017-c8myq6bi 258 33 lack lack NN cord-018017-c8myq6bi 258 34 of of IN cord-018017-c8myq6bi 258 35 error error NN cord-018017-c8myq6bi 258 36 proofreading proofreading NN cord-018017-c8myq6bi 258 37 by by IN cord-018017-c8myq6bi 258 38 the the DT cord-018017-c8myq6bi 258 39 viral viral JJ cord-018017-c8myq6bi 258 40 polymerase polymerase NN cord-018017-c8myq6bi 258 41 leading lead VBG cord-018017-c8myq6bi 258 42 to to IN cord-018017-c8myq6bi 258 43 mutations mutation NNS cord-018017-c8myq6bi 258 44 in in IN cord-018017-c8myq6bi 258 45 response response NN cord-018017-c8myq6bi 258 46 to to IN cord-018017-c8myq6bi 258 47 immune immune JJ cord-018017-c8myq6bi 258 48 pressure pressure NN cord-018017-c8myq6bi 258 49 . . . cord-018017-c8myq6bi 259 1 The the DT cord-018017-c8myq6bi 259 2 genetic genetic JJ cord-018017-c8myq6bi 259 3 variability variability NN cord-018017-c8myq6bi 259 4 of of IN cord-018017-c8myq6bi 259 5 HCV HCV NNP cord-018017-c8myq6bi 259 6 has have VBZ cord-018017-c8myq6bi 259 7 limited limit VBN cord-018017-c8myq6bi 259 8 efforts effort NNS cord-018017-c8myq6bi 259 9 to to TO cord-018017-c8myq6bi 259 10 design design VB cord-018017-c8myq6bi 259 11 an an DT cord-018017-c8myq6bi 259 12 effective effective JJ cord-018017-c8myq6bi 259 13 vaccine vaccine NN cord-018017-c8myq6bi 259 14 . . . cord-018017-c8myq6bi 260 1 The the DT cord-018017-c8myq6bi 260 2 polyomaviruses polyomaviruse NNS cord-018017-c8myq6bi 260 3 are be VBP cord-018017-c8myq6bi 260 4 small small JJ cord-018017-c8myq6bi 260 5 ( ( -LRB- cord-018017-c8myq6bi 260 6 3.4 3.4 CD cord-018017-c8myq6bi 260 7 kbp kbp NNP cord-018017-c8myq6bi 260 8 ) ) -RRB- cord-018017-c8myq6bi 260 9 , , , cord-018017-c8myq6bi 260 10 double double RB cord-018017-c8myq6bi 260 11 - - HYPH cord-018017-c8myq6bi 260 12 stranded strand VBN cord-018017-c8myq6bi 260 13 DNA dna NN cord-018017-c8myq6bi 260 14 viruses virus NNS cord-018017-c8myq6bi 260 15 . . . cord-018017-c8myq6bi 261 1 Early early JJ cord-018017-c8myq6bi 261 2 studies study NNS cord-018017-c8myq6bi 261 3 with with IN cord-018017-c8myq6bi 261 4 simian simian JJ cord-018017-c8myq6bi 261 5 virus virus NN cord-018017-c8myq6bi 261 6 40 40 CD cord-018017-c8myq6bi 262 1 ( ( -LRB- cord-018017-c8myq6bi 262 2 SV40 SV40 NNP cord-018017-c8myq6bi 262 3 ) ) -RRB- cord-018017-c8myq6bi 262 4 led lead VBD cord-018017-c8myq6bi 262 5 to to IN cord-018017-c8myq6bi 262 6 identification identification NN cord-018017-c8myq6bi 262 7 of of IN cord-018017-c8myq6bi 262 8 the the DT cord-018017-c8myq6bi 262 9 large large JJ cord-018017-c8myq6bi 262 10 tumor tumor NN cord-018017-c8myq6bi 262 11 antigen antigen NN cord-018017-c8myq6bi 262 12 ( ( -LRB- cord-018017-c8myq6bi 262 13 large large JJ cord-018017-c8myq6bi 262 14 T t NN cord-018017-c8myq6bi 262 15 ; ; : cord-018017-c8myq6bi 262 16 LT LT NNP cord-018017-c8myq6bi 262 17 ) ) -RRB- cord-018017-c8myq6bi 262 18 . . . cord-018017-c8myq6bi 263 1 LT LT NNP cord-018017-c8myq6bi 263 2 is be VBZ cord-018017-c8myq6bi 263 3 also also RB cord-018017-c8myq6bi 263 4 found find VBN cord-018017-c8myq6bi 263 5 in in IN cord-018017-c8myq6bi 263 6 BK BK NNP cord-018017-c8myq6bi 263 7 and and CC cord-018017-c8myq6bi 263 8 JC JC NNP cord-018017-c8myq6bi 263 9 viruses virus NNS cord-018017-c8myq6bi 263 10 which which WDT cord-018017-c8myq6bi 263 11 are be VBP cord-018017-c8myq6bi 263 12 more more RBR cord-018017-c8myq6bi 263 13 suspect suspect JJ cord-018017-c8myq6bi 263 14 human human JJ cord-018017-c8myq6bi 263 15 tumor tumor NN cord-018017-c8myq6bi 263 16 viruses virus NNS cord-018017-c8myq6bi 263 17 and and CC cord-018017-c8myq6bi 263 18 Merkel Merkel NNP cord-018017-c8myq6bi 263 19 cell cell NN cord-018017-c8myq6bi 263 20 polyomavirus polyomavirus NNP cord-018017-c8myq6bi 263 21 ( ( -LRB- cord-018017-c8myq6bi 263 22 MCV MCV NNP cord-018017-c8myq6bi 263 23 ) ) -RRB- cord-018017-c8myq6bi 263 24 which which WDT cord-018017-c8myq6bi 263 25 is be VBZ cord-018017-c8myq6bi 263 26 now now RB cord-018017-c8myq6bi 263 27 well well RB cord-018017-c8myq6bi 263 28 established establish VBN cord-018017-c8myq6bi 263 29 as as IN cord-018017-c8myq6bi 263 30 a a DT cord-018017-c8myq6bi 263 31 human human JJ cord-018017-c8myq6bi 263 32 tumor tumor NN cord-018017-c8myq6bi 263 33 virus virus NN cord-018017-c8myq6bi 263 34 ( ( -LRB- cord-018017-c8myq6bi 263 35 Feng Feng NNP cord-018017-c8myq6bi 263 36 et et FW cord-018017-c8myq6bi 263 37 al al NNP cord-018017-c8myq6bi 263 38 . . NNP cord-018017-c8myq6bi 263 39 2008 2008 CD cord-018017-c8myq6bi 263 40 ) ) -RRB- cord-018017-c8myq6bi 263 41 . . . cord-018017-c8myq6bi 264 1 The the DT cord-018017-c8myq6bi 264 2 N N NNP cord-018017-c8myq6bi 264 3 - - HYPH cord-018017-c8myq6bi 264 4 terminus terminus NN cord-018017-c8myq6bi 264 5 of of IN cord-018017-c8myq6bi 264 6 LT LT NNP cord-018017-c8myq6bi 264 7 contains contain VBZ cord-018017-c8myq6bi 264 8 an an DT cord-018017-c8myq6bi 264 9 LXCXE LXCXE NNP cord-018017-c8myq6bi 264 10 motif motif NN cord-018017-c8myq6bi 264 11 that that WDT cord-018017-c8myq6bi 264 12 interacts interact VBZ cord-018017-c8myq6bi 264 13 with with IN cord-018017-c8myq6bi 264 14 the the DT cord-018017-c8myq6bi 264 15 retinoblastoma retinoblastoma NN cord-018017-c8myq6bi 264 16 protein protein NN cord-018017-c8myq6bi 264 17 RB RB NNP cord-018017-c8myq6bi 264 18 while while IN cord-018017-c8myq6bi 264 19 the the DT cord-018017-c8myq6bi 264 20 C c NN cord-018017-c8myq6bi 264 21 - - HYPH cord-018017-c8myq6bi 264 22 terminus terminus NN cord-018017-c8myq6bi 264 23 contains contain VBZ cord-018017-c8myq6bi 264 24 an an DT cord-018017-c8myq6bi 264 25 ATPase ATPase NNP cord-018017-c8myq6bi 264 26 / / SYM cord-018017-c8myq6bi 264 27 DNA dna NN cord-018017-c8myq6bi 264 28 helicase helicase NN cord-018017-c8myq6bi 264 29 domain domain NN cord-018017-c8myq6bi 264 30 that that WDT cord-018017-c8myq6bi 264 31 can can MD cord-018017-c8myq6bi 264 32 inactivate inactivate VB cord-018017-c8myq6bi 264 33 p53 p53 NN cord-018017-c8myq6bi 264 34 . . . cord-018017-c8myq6bi 265 1 The the DT cord-018017-c8myq6bi 265 2 LS ls NN cord-018017-c8myq6bi 265 3 - - HYPH cord-018017-c8myq6bi 265 4 p53 p53 NN cord-018017-c8myq6bi 265 5 complex complex NN cord-018017-c8myq6bi 265 6 activates activate VBZ cord-018017-c8myq6bi 265 7 insulin insulin NN cord-018017-c8myq6bi 265 8 - - HYPH cord-018017-c8myq6bi 265 9 like like JJ cord-018017-c8myq6bi 265 10 growth growth NN cord-018017-c8myq6bi 265 11 factor factor NN cord-018017-c8myq6bi 266 1 I -PRON- PRP cord-018017-c8myq6bi 266 2 ( ( -LRB- cord-018017-c8myq6bi 266 3 IGF IGF NNP cord-018017-c8myq6bi 266 4 - - HYPH cord-018017-c8myq6bi 266 5 I I NNP cord-018017-c8myq6bi 266 6 ) ) -RRB- cord-018017-c8myq6bi 266 7 which which WDT cord-018017-c8myq6bi 266 8 alone alone RB cord-018017-c8myq6bi 266 9 is be VBZ cord-018017-c8myq6bi 266 10 capable capable JJ cord-018017-c8myq6bi 266 11 of of IN cord-018017-c8myq6bi 266 12 cell cell NN cord-018017-c8myq6bi 266 13 transformation transformation NN cord-018017-c8myq6bi 266 14 . . . cord-018017-c8myq6bi 267 1 A a DT cord-018017-c8myq6bi 267 2 recent recent JJ cord-018017-c8myq6bi 267 3 report report NN cord-018017-c8myq6bi 267 4 of of IN cord-018017-c8myq6bi 267 5 morbidity morbidity NN cord-018017-c8myq6bi 267 6 and and CC cord-018017-c8myq6bi 267 7 mortality mortality NN cord-018017-c8myq6bi 267 8 reveals reveal VBZ cord-018017-c8myq6bi 267 9 heart heart NN cord-018017-c8myq6bi 267 10 disease disease NN cord-018017-c8myq6bi 267 11 and and CC cord-018017-c8myq6bi 267 12 cardiovascular cardiovascular JJ cord-018017-c8myq6bi 267 13 events event NNS cord-018017-c8myq6bi 267 14 are be VBP cord-018017-c8myq6bi 267 15 the the DT cord-018017-c8myq6bi 267 16 number number NN cord-018017-c8myq6bi 267 17 one one CD cord-018017-c8myq6bi 267 18 killer killer NN cord-018017-c8myq6bi 267 19 with with IN cord-018017-c8myq6bi 267 20 neoplasia neoplasia NN cord-018017-c8myq6bi 267 21 and and CC cord-018017-c8myq6bi 267 22 infections infection NNS cord-018017-c8myq6bi 267 23 following follow VBG cord-018017-c8myq6bi 267 24 close close RB cord-018017-c8myq6bi 267 25 behind behind RB cord-018017-c8myq6bi 267 26 . . . cord-018017-c8myq6bi 268 1 However however RB cord-018017-c8myq6bi 268 2 , , , cord-018017-c8myq6bi 268 3 infections infection NNS cord-018017-c8myq6bi 268 4 frequently frequently RB cord-018017-c8myq6bi 268 5 cause cause VBP cord-018017-c8myq6bi 268 6 neoplasia neoplasia NN cord-018017-c8myq6bi 268 7 and and CC cord-018017-c8myq6bi 268 8 cardiovascular cardiovascular JJ cord-018017-c8myq6bi 268 9 disease disease NN cord-018017-c8myq6bi 268 10 leading lead VBG cord-018017-c8myq6bi 268 11 to to IN cord-018017-c8myq6bi 268 12 death death NN cord-018017-c8myq6bi 268 13 . . . cord-018017-c8myq6bi 269 1 If if IN cord-018017-c8myq6bi 269 2 we -PRON- PRP cord-018017-c8myq6bi 269 3 combine combine VBP cord-018017-c8myq6bi 269 4 cardiovascular cardiovascular JJ cord-018017-c8myq6bi 269 5 events event NNS cord-018017-c8myq6bi 269 6 and and CC cord-018017-c8myq6bi 269 7 neoplasia neoplasia NN cord-018017-c8myq6bi 269 8 caused cause VBN cord-018017-c8myq6bi 269 9 by by IN cord-018017-c8myq6bi 269 10 infection infection NN cord-018017-c8myq6bi 269 11 , , , cord-018017-c8myq6bi 269 12 then then RB cord-018017-c8myq6bi 269 13 infectious infectious JJ cord-018017-c8myq6bi 269 14 disease disease NN cord-018017-c8myq6bi 269 15 is be VBZ cord-018017-c8myq6bi 269 16 the the DT cord-018017-c8myq6bi 269 17 most most RBS cord-018017-c8myq6bi 269 18 significant significant JJ cord-018017-c8myq6bi 269 19 threat threat NN cord-018017-c8myq6bi 269 20 to to IN cord-018017-c8myq6bi 269 21 human human JJ cord-018017-c8myq6bi 269 22 life life NN cord-018017-c8myq6bi 269 23 and and CC cord-018017-c8myq6bi 269 24 qualifies qualify VBZ cord-018017-c8myq6bi 269 25 as as IN cord-018017-c8myq6bi 269 26 the the DT cord-018017-c8myq6bi 269 27 area area NN cord-018017-c8myq6bi 269 28 of of IN cord-018017-c8myq6bi 269 29 greatest great JJS cord-018017-c8myq6bi 269 30 impact impact NN cord-018017-c8myq6bi 269 31 . . . cord-018017-c8myq6bi 270 1 The the DT cord-018017-c8myq6bi 270 2 picornavirus picornavirus NNP cord-018017-c8myq6bi 270 3 family family NN cord-018017-c8myq6bi 270 4 are be VBP cord-018017-c8myq6bi 270 5 small small JJ cord-018017-c8myq6bi 270 6 ( ( -LRB- cord-018017-c8myq6bi 270 7 pico- pico- JJ cord-018017-c8myq6bi 270 8 ) ) -RRB- cord-018017-c8myq6bi 270 9 , , , cord-018017-c8myq6bi 270 10 single single RB cord-018017-c8myq6bi 270 11 - - HYPH cord-018017-c8myq6bi 270 12 stranded stranded JJ cord-018017-c8myq6bi 270 13 , , , cord-018017-c8myq6bi 270 14 positive positive JJ cord-018017-c8myq6bi 270 15 sense sense NN cord-018017-c8myq6bi 271 1 RNA RNA NNP cord-018017-c8myq6bi 271 2 genome genome NN cord-018017-c8myq6bi 271 3 ( ( -LRB- cord-018017-c8myq6bi 271 4 7.4 7.4 CD cord-018017-c8myq6bi 271 5 kb kb NNS cord-018017-c8myq6bi 271 6 ) ) -RRB- cord-018017-c8myq6bi 271 7 viruses virus NNS cord-018017-c8myq6bi 271 8 that that WDT cord-018017-c8myq6bi 271 9 synthesize synthesize VBP cord-018017-c8myq6bi 271 10 a a DT cord-018017-c8myq6bi 271 11 single single JJ cord-018017-c8myq6bi 271 12 polyprotein polyprotein NN cord-018017-c8myq6bi 271 13 that that WDT cord-018017-c8myq6bi 271 14 is be VBZ cord-018017-c8myq6bi 271 15 cut cut VBN cord-018017-c8myq6bi 271 16 into into IN cord-018017-c8myq6bi 271 17 a a DT cord-018017-c8myq6bi 271 18 small small JJ cord-018017-c8myq6bi 271 19 collection collection NN cord-018017-c8myq6bi 271 20 of of IN cord-018017-c8myq6bi 271 21 functional functional JJ cord-018017-c8myq6bi 271 22 proteins protein NNS cord-018017-c8myq6bi 271 23 by by IN cord-018017-c8myq6bi 271 24 virally virally RB cord-018017-c8myq6bi 271 25 encoded encode VBN cord-018017-c8myq6bi 271 26 ( ( -LRB- cord-018017-c8myq6bi 271 27 2A 2A NNP cord-018017-c8myq6bi 271 28 and and CC cord-018017-c8myq6bi 271 29 3C 3C NNP cord-018017-c8myq6bi 271 30 ) ) -RRB- cord-018017-c8myq6bi 271 31 and and CC cord-018017-c8myq6bi 271 32 cellular cellular JJ cord-018017-c8myq6bi 271 33 proteases protease NNS cord-018017-c8myq6bi 271 34 . . . cord-018017-c8myq6bi 272 1 Poliovirus Poliovirus NNP cord-018017-c8myq6bi 272 2 is be VBZ cord-018017-c8myq6bi 272 3 a a DT cord-018017-c8myq6bi 272 4 picornavirus picornavirus NN cord-018017-c8myq6bi 272 5 that that WDT cord-018017-c8myq6bi 272 6 has have VBZ cord-018017-c8myq6bi 272 7 served serve VBN cord-018017-c8myq6bi 272 8 as as IN cord-018017-c8myq6bi 272 9 the the DT cord-018017-c8myq6bi 272 10 prototype prototype NN cord-018017-c8myq6bi 272 11 for for IN cord-018017-c8myq6bi 272 12 the the DT cord-018017-c8myq6bi 272 13 viral viral JJ cord-018017-c8myq6bi 272 14 family family NN cord-018017-c8myq6bi 272 15 . . . cord-018017-c8myq6bi 273 1 The the DT cord-018017-c8myq6bi 273 2 enteroviruses enterovirus NNS cord-018017-c8myq6bi 273 3 are be VBP cord-018017-c8myq6bi 273 4 a a DT cord-018017-c8myq6bi 273 5 group group NN cord-018017-c8myq6bi 273 6 of of IN cord-018017-c8myq6bi 273 7 picornaviruses picornavirus NNS cord-018017-c8myq6bi 273 8 that that WDT cord-018017-c8myq6bi 273 9 have have VBP cord-018017-c8myq6bi 273 10 been be VBN cord-018017-c8myq6bi 273 11 associated associate VBN cord-018017-c8myq6bi 273 12 with with IN cord-018017-c8myq6bi 273 13 cardiac cardiac JJ cord-018017-c8myq6bi 273 14 disease disease NN cord-018017-c8myq6bi 273 15 . . . cord-018017-c8myq6bi 274 1 Coxsackievirus Coxsackievirus NNP cord-018017-c8myq6bi 274 2 B B NNP cord-018017-c8myq6bi 274 3 ( ( -LRB- cord-018017-c8myq6bi 274 4 CVB CVB NNP cord-018017-c8myq6bi 274 5 ) ) -RRB- cord-018017-c8myq6bi 274 6 , , , cord-018017-c8myq6bi 274 7 Coxackievirus Coxackievirus NNP cord-018017-c8myq6bi 274 8 A A NNP cord-018017-c8myq6bi 274 9 ( ( -LRB- cord-018017-c8myq6bi 274 10 CVA CVA NNP cord-018017-c8myq6bi 274 11 ) ) -RRB- cord-018017-c8myq6bi 274 12 , , , cord-018017-c8myq6bi 274 13 and and CC cord-018017-c8myq6bi 274 14 echovirus echovirus NNP cord-018017-c8myq6bi 274 15 infections infection NNS cord-018017-c8myq6bi 274 16 lead lead VBP cord-018017-c8myq6bi 274 17 to to IN cord-018017-c8myq6bi 274 18 cardiac cardiac JJ cord-018017-c8myq6bi 274 19 signs sign NNS cord-018017-c8myq6bi 274 20 3.2 3.2 CD cord-018017-c8myq6bi 274 21 % % NN cord-018017-c8myq6bi 274 22 of of IN cord-018017-c8myq6bi 274 23 the the DT cord-018017-c8myq6bi 274 24 time time NN cord-018017-c8myq6bi 274 25 . . . cord-018017-c8myq6bi 275 1 About about RB cord-018017-c8myq6bi 275 2 one one CD cord-018017-c8myq6bi 275 3 - - HYPH cord-018017-c8myq6bi 275 4 third third NN cord-018017-c8myq6bi 275 5 of of IN cord-018017-c8myq6bi 275 6 patients patient NNS cord-018017-c8myq6bi 275 7 with with IN cord-018017-c8myq6bi 275 8 acute acute JJ cord-018017-c8myq6bi 275 9 cardiac cardiac JJ cord-018017-c8myq6bi 275 10 disease disease NN cord-018017-c8myq6bi 275 11 ( ( -LRB- cord-018017-c8myq6bi 275 12 inflammation inflammation NN cord-018017-c8myq6bi 275 13 of of IN cord-018017-c8myq6bi 275 14 the the DT cord-018017-c8myq6bi 275 15 heart heart NN cord-018017-c8myq6bi 275 16 ) ) -RRB- cord-018017-c8myq6bi 275 17 are be VBP cord-018017-c8myq6bi 275 18 antibody antibody NN cord-018017-c8myq6bi 275 19 positive positive JJ cord-018017-c8myq6bi 275 20 for for IN cord-018017-c8myq6bi 275 21 enteroviruses enterovirus NNS cord-018017-c8myq6bi 275 22 . . . cord-018017-c8myq6bi 276 1 While while IN cord-018017-c8myq6bi 276 2 acute acute JJ cord-018017-c8myq6bi 276 3 myocarditis myocarditis NN cord-018017-c8myq6bi 276 4 is be VBZ cord-018017-c8myq6bi 276 5 often often RB cord-018017-c8myq6bi 276 6 self self NN cord-018017-c8myq6bi 276 7 - - HYPH cord-018017-c8myq6bi 276 8 limiting limit VBG cord-018017-c8myq6bi 276 9 , , , cord-018017-c8myq6bi 276 10 chronic chronic JJ cord-018017-c8myq6bi 276 11 cardiac cardiac JJ cord-018017-c8myq6bi 276 12 disease disease NN cord-018017-c8myq6bi 276 13 often often RB cord-018017-c8myq6bi 276 14 leads lead VBZ cord-018017-c8myq6bi 276 15 to to IN cord-018017-c8myq6bi 276 16 dilated dilated JJ cord-018017-c8myq6bi 276 17 cardiomyopathy cardiomyopathy NN cord-018017-c8myq6bi 276 18 ( ( -LRB- cord-018017-c8myq6bi 276 19 DCM DCM NNP cord-018017-c8myq6bi 276 20 ) ) -RRB- cord-018017-c8myq6bi 276 21 which which WDT cord-018017-c8myq6bi 276 22 is be VBZ cord-018017-c8myq6bi 276 23 present present JJ cord-018017-c8myq6bi 276 24 with with IN cord-018017-c8myq6bi 276 25 no no DT cord-018017-c8myq6bi 276 26 heart heart NN cord-018017-c8myq6bi 276 27 inflammation inflammation NN cord-018017-c8myq6bi 276 28 . . . cord-018017-c8myq6bi 277 1 DCM DCM NNP cord-018017-c8myq6bi 277 2 is be VBZ cord-018017-c8myq6bi 277 3 associated associate VBN cord-018017-c8myq6bi 277 4 with with IN cord-018017-c8myq6bi 277 5 heart heart NN cord-018017-c8myq6bi 277 6 failure failure NN cord-018017-c8myq6bi 277 7 which which WDT cord-018017-c8myq6bi 277 8 can can MD cord-018017-c8myq6bi 277 9 be be VB cord-018017-c8myq6bi 277 10 lethal lethal JJ cord-018017-c8myq6bi 277 11 ( ( -LRB- cord-018017-c8myq6bi 277 12 Table table NN cord-018017-c8myq6bi 277 13 3 3 CD cord-018017-c8myq6bi 277 14 .6 .6 CD cord-018017-c8myq6bi 277 15 ) ) -RRB- cord-018017-c8myq6bi 277 16 . . . cord-018017-c8myq6bi 278 1 These these DT cord-018017-c8myq6bi 278 2 chronic chronic JJ cord-018017-c8myq6bi 278 3 infections infection NNS cord-018017-c8myq6bi 278 4 lead lead VBP cord-018017-c8myq6bi 278 5 to to IN cord-018017-c8myq6bi 278 6 50 50 CD cord-018017-c8myq6bi 278 7 percent percent NN cord-018017-c8myq6bi 278 8 of of IN cord-018017-c8myq6bi 278 9 all all DT cord-018017-c8myq6bi 278 10 cardiac cardiac JJ cord-018017-c8myq6bi 278 11 transplants transplant NNS cord-018017-c8myq6bi 278 12 worldwide worldwide RB cord-018017-c8myq6bi 278 13 . . . cord-018017-c8myq6bi 279 1 The the DT cord-018017-c8myq6bi 279 2 enteroviral enteroviral JJ cord-018017-c8myq6bi 279 3 2A 2a CD cord-018017-c8myq6bi 279 4 protease protease NN cord-018017-c8myq6bi 279 5 can can MD cord-018017-c8myq6bi 279 6 also also RB cord-018017-c8myq6bi 279 7 degrade degrade VB cord-018017-c8myq6bi 279 8 dystrophin dystrophin NN cord-018017-c8myq6bi 279 9 in in IN cord-018017-c8myq6bi 279 10 the the DT cord-018017-c8myq6bi 279 11 heart heart NN cord-018017-c8myq6bi 279 12 leading lead VBG cord-018017-c8myq6bi 279 13 to to IN cord-018017-c8myq6bi 279 14 cardiac cardiac JJ cord-018017-c8myq6bi 279 15 necrosis necrosis NN cord-018017-c8myq6bi 279 16 , , , cord-018017-c8myq6bi 279 17 reduced reduce VBN cord-018017-c8myq6bi 279 18 ejection ejection NN cord-018017-c8myq6bi 279 19 fraction fraction NN cord-018017-c8myq6bi 279 20 , , , cord-018017-c8myq6bi 279 21 and and CC cord-018017-c8myq6bi 279 22 then then RB cord-018017-c8myq6bi 279 23 to to IN cord-018017-c8myq6bi 279 24 dilated dilated JJ cord-018017-c8myq6bi 279 25 cardiomyopathy cardiomyopathy NN cord-018017-c8myq6bi 279 26 . . . cord-018017-c8myq6bi 280 1 Transmission transmission NN cord-018017-c8myq6bi 280 2 of of IN cord-018017-c8myq6bi 280 3 these these DT cord-018017-c8myq6bi 280 4 viruses virus NNS cord-018017-c8myq6bi 280 5 is be VBZ cord-018017-c8myq6bi 280 6 from from IN cord-018017-c8myq6bi 280 7 contaminated contaminate VBN cord-018017-c8myq6bi 280 8 food food NN cord-018017-c8myq6bi 280 9 and and CC cord-018017-c8myq6bi 280 10 water water NN cord-018017-c8myq6bi 280 11 . . . cord-018017-c8myq6bi 281 1 The the DT cord-018017-c8myq6bi 281 2 human human JJ cord-018017-c8myq6bi 281 3 herpesviruses herpesviruse NNS cord-018017-c8myq6bi 281 4 are be VBP cord-018017-c8myq6bi 281 5 large large JJ cord-018017-c8myq6bi 281 6 double double RB cord-018017-c8myq6bi 281 7 - - HYPH cord-018017-c8myq6bi 281 8 stranded strand VBN cord-018017-c8myq6bi 281 9 DNA dna NN cord-018017-c8myq6bi 281 10 genome genome NN cord-018017-c8myq6bi 281 11 viruses virus NNS cord-018017-c8myq6bi 281 12 . . . cord-018017-c8myq6bi 282 1 The the DT cord-018017-c8myq6bi 282 2 human human JJ cord-018017-c8myq6bi 282 3 herpesvirus-5 herpesvirus-5 NNP cord-018017-c8myq6bi 282 4 ( ( -LRB- cord-018017-c8myq6bi 282 5 HHV5 HHV5 NNP cord-018017-c8myq6bi 282 6 ) ) -RRB- cord-018017-c8myq6bi 282 7 or or CC cord-018017-c8myq6bi 282 8 cytomegalovirus cytomegalovirus NNP cord-018017-c8myq6bi 282 9 ( ( -LRB- cord-018017-c8myq6bi 282 10 CMV CMV NNP cord-018017-c8myq6bi 282 11 ) ) -RRB- cord-018017-c8myq6bi 282 12 has have VBZ cord-018017-c8myq6bi 282 13 a a DT cord-018017-c8myq6bi 282 14 235 235 CD cord-018017-c8myq6bi 282 15 kbp kbp NN cord-018017-c8myq6bi 282 16 genome genome NN cord-018017-c8myq6bi 282 17 encoding encoding NN cord-018017-c8myq6bi 282 18 over over IN cord-018017-c8myq6bi 282 19 two two CD cord-018017-c8myq6bi 282 20 hundred hundred CD cord-018017-c8myq6bi 282 21 genes gene NNS cord-018017-c8myq6bi 282 22 . . . cord-018017-c8myq6bi 283 1 One one CD cord-018017-c8myq6bi 283 2 problem problem NN cord-018017-c8myq6bi 283 3 in in IN cord-018017-c8myq6bi 283 4 finding find VBG cord-018017-c8myq6bi 283 5 associations association NNS cord-018017-c8myq6bi 283 6 with with IN cord-018017-c8myq6bi 283 7 CMV CMV NNP cord-018017-c8myq6bi 283 8 infections infection NNS cord-018017-c8myq6bi 283 9 is be VBZ cord-018017-c8myq6bi 283 10 that that IN cord-018017-c8myq6bi 283 11 it -PRON- PRP cord-018017-c8myq6bi 283 12 is be VBZ cord-018017-c8myq6bi 283 13 not not RB cord-018017-c8myq6bi 283 14 an an DT cord-018017-c8myq6bi 283 15 emerging emerge VBG cord-018017-c8myq6bi 283 16 disease disease NN cord-018017-c8myq6bi 283 17 , , , cord-018017-c8myq6bi 283 18 50 50 CD cord-018017-c8myq6bi 283 19 to to TO cord-018017-c8myq6bi 283 20 99 99 CD cord-018017-c8myq6bi 283 21 % % NN cord-018017-c8myq6bi 283 22 of of IN cord-018017-c8myq6bi 283 23 the the DT cord-018017-c8myq6bi 283 24 population population NN cord-018017-c8myq6bi 283 25 has have VBZ cord-018017-c8myq6bi 283 26 been be VBN cord-018017-c8myq6bi 283 27 infected infect VBN cord-018017-c8myq6bi 283 28 making make VBG cord-018017-c8myq6bi 283 29 comparisons comparison NNS cord-018017-c8myq6bi 283 30 to to IN cord-018017-c8myq6bi 283 31 a a DT cord-018017-c8myq6bi 283 32 control control NN cord-018017-c8myq6bi 283 33 group group NN cord-018017-c8myq6bi 283 34 challenging challenge VBG cord-018017-c8myq6bi 283 35 . . . cord-018017-c8myq6bi 284 1 Most Most JJS cord-018017-c8myq6bi 284 2 infections infection NNS cord-018017-c8myq6bi 284 3 are be VBP cord-018017-c8myq6bi 284 4 observed observe VBN cord-018017-c8myq6bi 284 5 in in IN cord-018017-c8myq6bi 284 6 children child NNS cord-018017-c8myq6bi 284 7 and and CC cord-018017-c8myq6bi 284 8 in in IN cord-018017-c8myq6bi 284 9 newborns newborn NNS cord-018017-c8myq6bi 284 10 serious serious JJ cord-018017-c8myq6bi 284 11 clinical clinical JJ cord-018017-c8myq6bi 284 12 findings finding NNS cord-018017-c8myq6bi 284 13 can can MD cord-018017-c8myq6bi 284 14 be be VB cord-018017-c8myq6bi 284 15 observed observe VBN cord-018017-c8myq6bi 284 16 . . . cord-018017-c8myq6bi 285 1 Hence hence RB cord-018017-c8myq6bi 285 2 , , , cord-018017-c8myq6bi 285 3 most most JJS cord-018017-c8myq6bi 285 4 adults adult NNS cord-018017-c8myq6bi 285 5 carry carry VBP cord-018017-c8myq6bi 285 6 latent latent JJ cord-018017-c8myq6bi 285 7 infections infection NNS cord-018017-c8myq6bi 285 8 that that WDT cord-018017-c8myq6bi 285 9 are be VBP cord-018017-c8myq6bi 285 10 reactivated reactivate VBN cord-018017-c8myq6bi 285 11 when when WRB cord-018017-c8myq6bi 285 12 individuals individual NNS cord-018017-c8myq6bi 285 13 become become VBP cord-018017-c8myq6bi 285 14 immune immune JJ cord-018017-c8myq6bi 285 15 suppressed suppress VBN cord-018017-c8myq6bi 285 16 following follow VBG cord-018017-c8myq6bi 285 17 solid solid JJ cord-018017-c8myq6bi 285 18 organ organ NN cord-018017-c8myq6bi 285 19 transplantation transplantation NN cord-018017-c8myq6bi 285 20 , , , cord-018017-c8myq6bi 285 21 malignant malignant JJ cord-018017-c8myq6bi 285 22 hematological hematological JJ cord-018017-c8myq6bi 285 23 disease disease NN cord-018017-c8myq6bi 285 24 , , , cord-018017-c8myq6bi 285 25 and and CC cord-018017-c8myq6bi 285 26 AIDS AIDS NNP cord-018017-c8myq6bi 285 27 . . . cord-018017-c8myq6bi 286 1 Reactivation reactivation NN cord-018017-c8myq6bi 286 2 in in IN cord-018017-c8myq6bi 286 3 immune immune JJ cord-018017-c8myq6bi 286 4 suppressed suppress VBN cord-018017-c8myq6bi 286 5 individuals individual NNS cord-018017-c8myq6bi 286 6 is be VBZ cord-018017-c8myq6bi 286 7 associated associate VBN cord-018017-c8myq6bi 286 8 with with IN cord-018017-c8myq6bi 286 9 increased increase VBN cord-018017-c8myq6bi 286 10 mortality mortality NN cord-018017-c8myq6bi 286 11 . . . cord-018017-c8myq6bi 287 1 The the DT cord-018017-c8myq6bi 287 2 association association NN cord-018017-c8myq6bi 287 3 with with IN cord-018017-c8myq6bi 287 4 cardiovascular cardiovascular JJ cord-018017-c8myq6bi 287 5 disease disease NN cord-018017-c8myq6bi 287 6 has have VBZ cord-018017-c8myq6bi 287 7 been be VBN cord-018017-c8myq6bi 287 8 demonstrated demonstrate VBN cord-018017-c8myq6bi 287 9 in in IN cord-018017-c8myq6bi 287 10 two two CD cord-018017-c8myq6bi 287 11 recent recent JJ cord-018017-c8myq6bi 287 12 studies study NNS cord-018017-c8myq6bi 287 13 . . . cord-018017-c8myq6bi 288 1 In in IN cord-018017-c8myq6bi 288 2 one one CD cord-018017-c8myq6bi 288 3 , , , cord-018017-c8myq6bi 288 4 CMV CMV NNP cord-018017-c8myq6bi 288 5 infections infection NNS cord-018017-c8myq6bi 288 6 were be VBD cord-018017-c8myq6bi 288 7 detected detect VBN cord-018017-c8myq6bi 288 8 in in IN cord-018017-c8myq6bi 288 9 14.5 14.5 CD cord-018017-c8myq6bi 288 10 percent percent NN cord-018017-c8myq6bi 288 11 of of IN cord-018017-c8myq6bi 288 12 coronary coronary JJ cord-018017-c8myq6bi 288 13 artery artery NN cord-018017-c8myq6bi 288 14 samples sample NNS cord-018017-c8myq6bi 288 15 from from IN cord-018017-c8myq6bi 288 16 bypass bypass NN cord-018017-c8myq6bi 288 17 operations operation NNS cord-018017-c8myq6bi 288 18 compared compare VBN cord-018017-c8myq6bi 288 19 to to IN cord-018017-c8myq6bi 288 20 4 4 CD cord-018017-c8myq6bi 288 21 percent percent NN cord-018017-c8myq6bi 288 22 in in IN cord-018017-c8myq6bi 288 23 of of IN cord-018017-c8myq6bi 288 24 patients patient NNS cord-018017-c8myq6bi 288 25 who who WP cord-018017-c8myq6bi 288 26 needed need VBD cord-018017-c8myq6bi 288 27 cardiac cardiac JJ cord-018017-c8myq6bi 288 28 surgery surgery NN cord-018017-c8myq6bi 288 29 for for IN cord-018017-c8myq6bi 288 30 reasons reason NNS cord-018017-c8myq6bi 288 31 other other JJ cord-018017-c8myq6bi 288 32 than than IN cord-018017-c8myq6bi 288 33 atherosclerosis atherosclerosis NN cord-018017-c8myq6bi 289 1 Hebar Hebar NNP cord-018017-c8myq6bi 289 2 et et NNP cord-018017-c8myq6bi 289 3 al al NNP cord-018017-c8myq6bi 289 4 . . NNP cord-018017-c8myq6bi 289 5 2015 2015 CD cord-018017-c8myq6bi 289 6 ) ) -RRB- cord-018017-c8myq6bi 289 7 . . . cord-018017-c8myq6bi 290 1 In in IN cord-018017-c8myq6bi 290 2 the the DT cord-018017-c8myq6bi 290 3 other other JJ cord-018017-c8myq6bi 290 4 , , , cord-018017-c8myq6bi 290 5 CMV CMV NNP cord-018017-c8myq6bi 290 6 reactivation reactivation NN cord-018017-c8myq6bi 290 7 ( ( -LRB- cord-018017-c8myq6bi 290 8 viremia viremia NN cord-018017-c8myq6bi 290 9 ) ) -RRB- cord-018017-c8myq6bi 290 10 was be VBD cord-018017-c8myq6bi 290 11 detected detect VBN cord-018017-c8myq6bi 290 12 in in IN cord-018017-c8myq6bi 290 13 16.5 16.5 CD cord-018017-c8myq6bi 290 14 % % NN cord-018017-c8myq6bi 290 15 of of IN cord-018017-c8myq6bi 290 16 immunocompetent immunocompetent JJ cord-018017-c8myq6bi 290 17 patients patient NNS cord-018017-c8myq6bi 290 18 admitted admit VBN cord-018017-c8myq6bi 290 19 for for IN cord-018017-c8myq6bi 290 20 major major JJ cord-018017-c8myq6bi 290 21 heart heart NN cord-018017-c8myq6bi 290 22 surgery surgery NN cord-018017-c8myq6bi 291 1 ( ( -LRB- cord-018017-c8myq6bi 291 2 Roa Roa NNP cord-018017-c8myq6bi 291 3 et et FW cord-018017-c8myq6bi 291 4 al al NNP cord-018017-c8myq6bi 291 5 . . NNP cord-018017-c8myq6bi 291 6 2015 2015 CD cord-018017-c8myq6bi 291 7 ) ) -RRB- cord-018017-c8myq6bi 291 8 . . . cord-018017-c8myq6bi 292 1 The the DT cord-018017-c8myq6bi 292 2 incidence incidence NN cord-018017-c8myq6bi 292 3 of of IN cord-018017-c8myq6bi 292 4 coronary coronary JJ cord-018017-c8myq6bi 292 5 artery artery NN cord-018017-c8myq6bi 292 6 disease disease NN cord-018017-c8myq6bi 292 7 is be VBZ cord-018017-c8myq6bi 292 8 the the DT cord-018017-c8myq6bi 292 9 major major JJ cord-018017-c8myq6bi 292 10 contributor contributor NN cord-018017-c8myq6bi 292 11 to to IN cord-018017-c8myq6bi 292 12 death death NN cord-018017-c8myq6bi 292 13 from from IN cord-018017-c8myq6bi 292 14 heart heart NN cord-018017-c8myq6bi 292 15 disease disease NN cord-018017-c8myq6bi 292 16 and and CC cord-018017-c8myq6bi 292 17 if if IN cord-018017-c8myq6bi 292 18 14 14 CD cord-018017-c8myq6bi 292 19 to to TO cord-018017-c8myq6bi 292 20 16.5 16.5 CD cord-018017-c8myq6bi 292 21 % % NN cord-018017-c8myq6bi 292 22 of of IN cord-018017-c8myq6bi 292 23 this this DT cord-018017-c8myq6bi 292 24 disease disease NN cord-018017-c8myq6bi 292 25 is be VBZ cord-018017-c8myq6bi 292 26 associated associate VBN cord-018017-c8myq6bi 292 27 with with IN cord-018017-c8myq6bi 292 28 CMV CMV NNP cord-018017-c8myq6bi 292 29 infections infection NNS cord-018017-c8myq6bi 292 30 , , , cord-018017-c8myq6bi 292 31 this this DT cord-018017-c8myq6bi 292 32 infection infection NN cord-018017-c8myq6bi 292 33 is be VBZ cord-018017-c8myq6bi 292 34 a a DT cord-018017-c8myq6bi 292 35 significant significant JJ cord-018017-c8myq6bi 292 36 human human JJ cord-018017-c8myq6bi 292 37 health health NN cord-018017-c8myq6bi 292 38 hazard hazard NN cord-018017-c8myq6bi 292 39 . . . cord-018017-c8myq6bi 293 1 Recognizing recognize VBG cord-018017-c8myq6bi 293 2 an an DT cord-018017-c8myq6bi 293 3 emerging emerge VBG cord-018017-c8myq6bi 293 4 infectious infectious JJ cord-018017-c8myq6bi 293 5 disease disease NN cord-018017-c8myq6bi 293 6 involves involve VBZ cord-018017-c8myq6bi 293 7 well well RB cord-018017-c8myq6bi 293 8 established establish VBN cord-018017-c8myq6bi 293 9 strategies strategy NNS cord-018017-c8myq6bi 293 10 of of IN cord-018017-c8myq6bi 293 11 surveillance surveillance NN cord-018017-c8myq6bi 293 12 ; ; , cord-018017-c8myq6bi 293 13 ( ( -LRB- cord-018017-c8myq6bi 293 14 1 1 LS cord-018017-c8myq6bi 293 15 ) ) -RRB- cord-018017-c8myq6bi 293 16 identify identify VB cord-018017-c8myq6bi 293 17 unusual unusual JJ cord-018017-c8myq6bi 293 18 clusters cluster NNS cord-018017-c8myq6bi 293 19 of of IN cord-018017-c8myq6bi 293 20 disease disease NN cord-018017-c8myq6bi 293 21 , , , cord-018017-c8myq6bi 293 22 ( ( -LRB- cord-018017-c8myq6bi 293 23 2 2 LS cord-018017-c8myq6bi 293 24 ) ) -RRB- cord-018017-c8myq6bi 293 25 evaluate evaluate VB cord-018017-c8myq6bi 293 26 the the DT cord-018017-c8myq6bi 293 27 spread spread NN cord-018017-c8myq6bi 293 28 of of IN cord-018017-c8myq6bi 293 29 an an DT cord-018017-c8myq6bi 293 30 outbreak outbreak NN cord-018017-c8myq6bi 293 31 , , , cord-018017-c8myq6bi 293 32 ( ( -LRB- cord-018017-c8myq6bi 293 33 3 3 LS cord-018017-c8myq6bi 293 34 ) ) -RRB- cord-018017-c8myq6bi 293 35 estimate estimate VB cord-018017-c8myq6bi 293 36 the the DT cord-018017-c8myq6bi 293 37 magnitude magnitude NN cord-018017-c8myq6bi 293 38 of of IN cord-018017-c8myq6bi 293 39 the the DT cord-018017-c8myq6bi 293 40 problem problem NN cord-018017-c8myq6bi 293 41 , , , cord-018017-c8myq6bi 293 42 and and CC cord-018017-c8myq6bi 293 43 ( ( -LRB- cord-018017-c8myq6bi 293 44 4 4 LS cord-018017-c8myq6bi 293 45 ) ) -RRB- cord-018017-c8myq6bi 294 1 if if IN cord-018017-c8myq6bi 294 2 possible possible JJ cord-018017-c8myq6bi 294 3 identify identify VB cord-018017-c8myq6bi 294 4 the the DT cord-018017-c8myq6bi 294 5 Atheroscleotic Atheroscleotic NNP cord-018017-c8myq6bi 294 6 plaque plaque NN cord-018017-c8myq6bi 294 7 infectious infectious JJ cord-018017-c8myq6bi 294 8 agent agent NN cord-018017-c8myq6bi 294 9 . . . cord-018017-c8myq6bi 295 1 The the DT cord-018017-c8myq6bi 295 2 strategy strategy NN cord-018017-c8myq6bi 295 3 has have VBZ cord-018017-c8myq6bi 295 4 proven prove VBN cord-018017-c8myq6bi 295 5 valuable valuable JJ cord-018017-c8myq6bi 295 6 for for IN cord-018017-c8myq6bi 295 7 known know VBN cord-018017-c8myq6bi 295 8 infectious infectious JJ cord-018017-c8myq6bi 295 9 and and CC cord-018017-c8myq6bi 295 10 noninfectious noninfectious JJ cord-018017-c8myq6bi 295 11 diseases disease NNS cord-018017-c8myq6bi 295 12 but but CC cord-018017-c8myq6bi 295 13 has have VBZ cord-018017-c8myq6bi 295 14 limited limit VBN cord-018017-c8myq6bi 295 15 capacity capacity NN cord-018017-c8myq6bi 295 16 to to TO cord-018017-c8myq6bi 295 17 detect detect VB cord-018017-c8myq6bi 295 18 emerging emerge VBG cord-018017-c8myq6bi 295 19 infectious infectious JJ cord-018017-c8myq6bi 295 20 diseases disease NNS cord-018017-c8myq6bi 295 21 . . . cord-018017-c8myq6bi 296 1 However however RB cord-018017-c8myq6bi 296 2 , , , cord-018017-c8myq6bi 296 3 deviation deviation NN cord-018017-c8myq6bi 296 4 from from IN cord-018017-c8myq6bi 296 5 the the DT cord-018017-c8myq6bi 296 6 traditional traditional JJ cord-018017-c8myq6bi 296 7 approach approach NN cord-018017-c8myq6bi 296 8 to to IN cord-018017-c8myq6bi 296 9 surveillance surveillance NN cord-018017-c8myq6bi 296 10 is be VBZ cord-018017-c8myq6bi 296 11 not not RB cord-018017-c8myq6bi 296 12 likely likely JJ cord-018017-c8myq6bi 296 13 to to TO cord-018017-c8myq6bi 296 14 gain gain VB cord-018017-c8myq6bi 296 15 support support NN cord-018017-c8myq6bi 296 16 . . . cord-018017-c8myq6bi 297 1 Al Al NNP cord-018017-c8myq6bi 297 2 Smith Smith NNP cord-018017-c8myq6bi 297 3 , , , cord-018017-c8myq6bi 297 4 a a DT cord-018017-c8myq6bi 297 5 veterinary veterinary JJ cord-018017-c8myq6bi 297 6 virologist virologist NN cord-018017-c8myq6bi 297 7 , , , cord-018017-c8myq6bi 297 8 approached approach VBD cord-018017-c8myq6bi 297 9 me -PRON- PRP cord-018017-c8myq6bi 297 10 after after IN cord-018017-c8myq6bi 297 11 a a DT cord-018017-c8myq6bi 297 12 seminar seminar NN cord-018017-c8myq6bi 297 13 I -PRON- PRP cord-018017-c8myq6bi 297 14 presented present VBD cord-018017-c8myq6bi 297 15 in in IN cord-018017-c8myq6bi 297 16 1997 1997 CD cord-018017-c8myq6bi 297 17 in in IN cord-018017-c8myq6bi 297 18 the the DT cord-018017-c8myq6bi 297 19 College College NNP cord-018017-c8myq6bi 297 20 of of IN cord-018017-c8myq6bi 297 21 Veterinary Veterinary NNP cord-018017-c8myq6bi 297 22 Medicine Medicine NNP cord-018017-c8myq6bi 297 23 at at IN cord-018017-c8myq6bi 297 24 Oregon Oregon NNP cord-018017-c8myq6bi 297 25 State State NNP cord-018017-c8myq6bi 297 26 University University NNP cord-018017-c8myq6bi 297 27 . . . cord-018017-c8myq6bi 298 1 I -PRON- PRP cord-018017-c8myq6bi 298 2 had have VBD cord-018017-c8myq6bi 298 3 just just RB cord-018017-c8myq6bi 298 4 joined join VBN cord-018017-c8myq6bi 298 5 AVI AVI NNP cord-018017-c8myq6bi 298 6 BioPharma BioPharma NNP cord-018017-c8myq6bi 298 7 as as IN cord-018017-c8myq6bi 298 8 the the DT cord-018017-c8myq6bi 298 9 head head NN cord-018017-c8myq6bi 298 10 of of IN cord-018017-c8myq6bi 298 11 their -PRON- PRP$ cord-018017-c8myq6bi 298 12 research research NN cord-018017-c8myq6bi 298 13 and and CC cord-018017-c8myq6bi 298 14 development development NN cord-018017-c8myq6bi 298 15 program program NN cord-018017-c8myq6bi 298 16 . . . cord-018017-c8myq6bi 299 1 Al Al NNP cord-018017-c8myq6bi 299 2 was be VBD cord-018017-c8myq6bi 299 3 a a DT cord-018017-c8myq6bi 299 4 veterinarian veterinarian NN cord-018017-c8myq6bi 299 5 and and CC cord-018017-c8myq6bi 299 6 professor professor NN cord-018017-c8myq6bi 299 7 and and CC cord-018017-c8myq6bi 299 8 had have VBD cord-018017-c8myq6bi 299 9 devoted devote VBN cord-018017-c8myq6bi 299 10 his -PRON- PRP$ cord-018017-c8myq6bi 299 11 career career NN cord-018017-c8myq6bi 299 12 to to IN cord-018017-c8myq6bi 299 13 the the DT cord-018017-c8myq6bi 299 14 Caliciviridae Caliciviridae NNP cord-018017-c8myq6bi 299 15 family family NN cord-018017-c8myq6bi 299 16 of of IN cord-018017-c8myq6bi 299 17 viruses virus NNS cord-018017-c8myq6bi 299 18 dating date VBG cord-018017-c8myq6bi 299 19 back back RB cord-018017-c8myq6bi 299 20 to to IN cord-018017-c8myq6bi 299 21 his -PRON- PRP$ cord-018017-c8myq6bi 299 22 time time NN cord-018017-c8myq6bi 299 23 in in IN cord-018017-c8myq6bi 299 24 the the DT cord-018017-c8myq6bi 299 25 naval naval JJ cord-018017-c8myq6bi 299 26 research research NN cord-018017-c8myq6bi 299 27 station station NN cord-018017-c8myq6bi 299 28 in in IN cord-018017-c8myq6bi 299 29 California California NNP cord-018017-c8myq6bi 299 30 . . . cord-018017-c8myq6bi 300 1 He -PRON- PRP cord-018017-c8myq6bi 300 2 had have VBD cord-018017-c8myq6bi 300 3 isolated isolate VBN cord-018017-c8myq6bi 300 4 the the DT cord-018017-c8myq6bi 300 5 nonhuman nonhuman NN cord-018017-c8myq6bi 300 6 vesivirus vesivirus NNP cord-018017-c8myq6bi 300 7 group group NN cord-018017-c8myq6bi 300 8 of of IN cord-018017-c8myq6bi 300 9 caliciviruses caliciviruse NNS cord-018017-c8myq6bi 300 10 not not RB cord-018017-c8myq6bi 300 11 only only RB cord-018017-c8myq6bi 300 12 from from IN cord-018017-c8myq6bi 300 13 suffering suffer VBG cord-018017-c8myq6bi 300 14 sea sea NN cord-018017-c8myq6bi 300 15 lions lion NNS cord-018017-c8myq6bi 300 16 in in IN cord-018017-c8myq6bi 300 17 the the DT cord-018017-c8myq6bi 300 18 Channel Channel NNP cord-018017-c8myq6bi 300 19 Islands Islands NNPS cord-018017-c8myq6bi 300 20 , , , cord-018017-c8myq6bi 300 21 but but CC cord-018017-c8myq6bi 300 22 from from IN cord-018017-c8myq6bi 300 23 reptiles reptile NNS cord-018017-c8myq6bi 300 24 in in IN cord-018017-c8myq6bi 300 25 the the DT cord-018017-c8myq6bi 300 26 San San NNP cord-018017-c8myq6bi 300 27 Diego Diego NNP cord-018017-c8myq6bi 300 28 zoo zoo NN cord-018017-c8myq6bi 300 29 and and CC cord-018017-c8myq6bi 300 30 whales whale NNS cord-018017-c8myq6bi 300 31 held hold VBN cord-018017-c8myq6bi 300 32 in in IN cord-018017-c8myq6bi 300 33 captivity captivity NN cord-018017-c8myq6bi 300 34 . . . cord-018017-c8myq6bi 301 1 Al Al NNP cord-018017-c8myq6bi 301 2 and and CC cord-018017-c8myq6bi 301 3 his -PRON- PRP$ cord-018017-c8myq6bi 301 4 capable capable JJ cord-018017-c8myq6bi 301 5 technician technician NN cord-018017-c8myq6bi 301 6 , , , cord-018017-c8myq6bi 301 7 Doug Doug NNP cord-018017-c8myq6bi 301 8 Skilling Skilling NNP cord-018017-c8myq6bi 301 9 successfully successfully RB cord-018017-c8myq6bi 301 10 propagated propagate VBD cord-018017-c8myq6bi 301 11 the the DT cord-018017-c8myq6bi 301 12 virus virus NN cord-018017-c8myq6bi 301 13 isolates isolate VBZ cord-018017-c8myq6bi 301 14 in in IN cord-018017-c8myq6bi 301 15 cell cell NN cord-018017-c8myq6bi 301 16 culture culture NN cord-018017-c8myq6bi 301 17 , , , cord-018017-c8myq6bi 301 18 an an DT cord-018017-c8myq6bi 301 19 accomplishment accomplishment NN cord-018017-c8myq6bi 301 20 not not RB cord-018017-c8myq6bi 301 21 shared share VBN cord-018017-c8myq6bi 301 22 by by IN cord-018017-c8myq6bi 301 23 other other JJ cord-018017-c8myq6bi 301 24 laboratories laboratory NNS cord-018017-c8myq6bi 301 25 at at IN cord-018017-c8myq6bi 301 26 the the DT cord-018017-c8myq6bi 301 27 time time NN cord-018017-c8myq6bi 301 28 . . . cord-018017-c8myq6bi 302 1 Al Al NNP cord-018017-c8myq6bi 302 2 developed develop VBD cord-018017-c8myq6bi 302 3 nucleic nucleic JJ cord-018017-c8myq6bi 302 4 acid acid NN cord-018017-c8myq6bi 302 5 probes probe NNS cord-018017-c8myq6bi 302 6 and and CC cord-018017-c8myq6bi 302 7 induced induce VBN cord-018017-c8myq6bi 302 8 antibodies antibody NNS cord-018017-c8myq6bi 302 9 to to IN cord-018017-c8myq6bi 302 10 these these DT cord-018017-c8myq6bi 302 11 viral viral JJ cord-018017-c8myq6bi 302 12 isolates isolate NNS cord-018017-c8myq6bi 302 13 . . . cord-018017-c8myq6bi 303 1 Over over IN cord-018017-c8myq6bi 303 2 decades decade NNS cord-018017-c8myq6bi 303 3 of of IN cord-018017-c8myq6bi 303 4 research research NN cord-018017-c8myq6bi 303 5 he -PRON- PRP cord-018017-c8myq6bi 303 6 assembled assemble VBD cord-018017-c8myq6bi 303 7 an an DT cord-018017-c8myq6bi 303 8 extensive extensive JJ cord-018017-c8myq6bi 303 9 collection collection NN cord-018017-c8myq6bi 303 10 of of IN cord-018017-c8myq6bi 303 11 vesiviruses vesiviruse NNS cord-018017-c8myq6bi 303 12 which which WDT cord-018017-c8myq6bi 303 13 were be VBD cord-018017-c8myq6bi 303 14 held hold VBN cord-018017-c8myq6bi 303 15 in in IN cord-018017-c8myq6bi 303 16 redundant redundant JJ cord-018017-c8myq6bi 303 17 −70 −70 NNP cord-018017-c8myq6bi 303 18 ° ° NNS cord-018017-c8myq6bi 303 19 freezers freezer NNS cord-018017-c8myq6bi 303 20 . . . cord-018017-c8myq6bi 304 1 His -PRON- PRP$ cord-018017-c8myq6bi 304 2 singular singular JJ cord-018017-c8myq6bi 304 3 vesivirus vesivirus NN cord-018017-c8myq6bi 304 4 focus focus NN cord-018017-c8myq6bi 304 5 gave give VBD cord-018017-c8myq6bi 304 6 the the DT cord-018017-c8myq6bi 304 7 appearance appearance NN cord-018017-c8myq6bi 304 8 of of IN cord-018017-c8myq6bi 304 9 a a DT cord-018017-c8myq6bi 304 10 zealot zealot NN cord-018017-c8myq6bi 304 11 but but CC cord-018017-c8myq6bi 304 12 his -PRON- PRP$ cord-018017-c8myq6bi 304 13 ability ability NN cord-018017-c8myq6bi 304 14 to to TO cord-018017-c8myq6bi 304 15 cultivate cultivate VB cord-018017-c8myq6bi 304 16 viral viral JJ cord-018017-c8myq6bi 304 17 isolates isolate NNS cord-018017-c8myq6bi 304 18 , , , cord-018017-c8myq6bi 304 19 his -PRON- PRP$ cord-018017-c8myq6bi 304 20 extensive extensive JJ cord-018017-c8myq6bi 304 21 collection collection NN cord-018017-c8myq6bi 304 22 of of IN cord-018017-c8myq6bi 304 23 isolates isolate NNS cord-018017-c8myq6bi 304 24 , , , cord-018017-c8myq6bi 304 25 and and CC cord-018017-c8myq6bi 304 26 his -PRON- PRP$ cord-018017-c8myq6bi 304 27 one one CD cord-018017-c8myq6bi 304 28 of of IN cord-018017-c8myq6bi 304 29 a a DT cord-018017-c8myq6bi 304 30 kind kind JJ cord-018017-c8myq6bi 304 31 detection detection NN cord-018017-c8myq6bi 304 32 reagents reagent NNS cord-018017-c8myq6bi 304 33 made make VBD cord-018017-c8myq6bi 304 34 him -PRON- PRP cord-018017-c8myq6bi 304 35 a a DT cord-018017-c8myq6bi 304 36 one one CD cord-018017-c8myq6bi 304 37 of of IN cord-018017-c8myq6bi 304 38 a a DT cord-018017-c8myq6bi 304 39 kind kind NN cord-018017-c8myq6bi 304 40 virologist virologist NN cord-018017-c8myq6bi 304 41 . . . cord-018017-c8myq6bi 305 1 Al Al NNP cord-018017-c8myq6bi 305 2 was be VBD cord-018017-c8myq6bi 305 3 well well RB cord-018017-c8myq6bi 305 4 beyond beyond IN cord-018017-c8myq6bi 305 5 retirement retirement NN cord-018017-c8myq6bi 305 6 age age NN cord-018017-c8myq6bi 305 7 and and CC cord-018017-c8myq6bi 305 8 was be VBD cord-018017-c8myq6bi 305 9 an an DT cord-018017-c8myq6bi 305 10 " " `` cord-018017-c8myq6bi 305 11 old old JJ cord-018017-c8myq6bi 305 12 school school NN cord-018017-c8myq6bi 305 13 " " '' cord-018017-c8myq6bi 305 14 virologist virologist NN cord-018017-c8myq6bi 305 15 ready ready JJ cord-018017-c8myq6bi 305 16 at at IN cord-018017-c8myq6bi 305 17 a a DT cord-018017-c8myq6bi 305 18 moment moment NN cord-018017-c8myq6bi 305 19 's 's POS cord-018017-c8myq6bi 305 20 notice notice NN cord-018017-c8myq6bi 305 21 to to TO cord-018017-c8myq6bi 305 22 take take VB cord-018017-c8myq6bi 305 23 his -PRON- PRP$ cord-018017-c8myq6bi 305 24 bag bag NN cord-018017-c8myq6bi 305 25 into into IN cord-018017-c8myq6bi 305 26 the the DT cord-018017-c8myq6bi 305 27 real real JJ cord-018017-c8myq6bi 305 28 world world NN cord-018017-c8myq6bi 305 29 and and CC cord-018017-c8myq6bi 305 30 collect collect VB cord-018017-c8myq6bi 305 31 swabs swab NNS cord-018017-c8myq6bi 305 32 from from IN cord-018017-c8myq6bi 305 33 ailing ail VBG cord-018017-c8myq6bi 305 34 animals animal NNS cord-018017-c8myq6bi 305 35 . . . cord-018017-c8myq6bi 306 1 He -PRON- PRP cord-018017-c8myq6bi 306 2 maintained maintain VBD cord-018017-c8myq6bi 306 3 careful careful JJ cord-018017-c8myq6bi 306 4 records record NNS cord-018017-c8myq6bi 306 5 of of IN cord-018017-c8myq6bi 306 6 the the DT cord-018017-c8myq6bi 306 7 condition condition NN cord-018017-c8myq6bi 306 8 of of IN cord-018017-c8myq6bi 306 9 his -PRON- PRP$ cord-018017-c8myq6bi 306 10 patients patient NNS cord-018017-c8myq6bi 306 11 , , , cord-018017-c8myq6bi 306 12 their -PRON- PRP$ cord-018017-c8myq6bi 306 13 location location NN cord-018017-c8myq6bi 306 14 , , , cord-018017-c8myq6bi 306 15 and and CC cord-018017-c8myq6bi 306 16 the the DT cord-018017-c8myq6bi 306 17 setting setting NN cord-018017-c8myq6bi 306 18 of of IN cord-018017-c8myq6bi 306 19 the the DT cord-018017-c8myq6bi 306 20 animal animal NN cord-018017-c8myq6bi 306 21 in in IN cord-018017-c8myq6bi 306 22 the the DT cord-018017-c8myq6bi 306 23 community community NN cord-018017-c8myq6bi 306 24 . . . cord-018017-c8myq6bi 307 1 Every every DT cord-018017-c8myq6bi 307 2 field field NN cord-018017-c8myq6bi 307 3 trip trip NN cord-018017-c8myq6bi 307 4 led lead VBD cord-018017-c8myq6bi 307 5 to to TO cord-018017-c8myq6bi 307 6 work work VB cord-018017-c8myq6bi 307 7 in in IN cord-018017-c8myq6bi 307 8 the the DT cord-018017-c8myq6bi 307 9 lab lab NN cord-018017-c8myq6bi 307 10 propagating propagate VBG cord-018017-c8myq6bi 307 11 virus virus NN cord-018017-c8myq6bi 307 12 from from IN cord-018017-c8myq6bi 307 13 his -PRON- PRP$ cord-018017-c8myq6bi 307 14 swabs swab NNS cord-018017-c8myq6bi 307 15 . . . cord-018017-c8myq6bi 308 1 Al Al NNP cord-018017-c8myq6bi 308 2 wanted want VBD cord-018017-c8myq6bi 308 3 to to TO cord-018017-c8myq6bi 308 4 know know VB cord-018017-c8myq6bi 308 5 if if IN cord-018017-c8myq6bi 308 6 I -PRON- PRP cord-018017-c8myq6bi 308 7 would would MD cord-018017-c8myq6bi 308 8 be be VB cord-018017-c8myq6bi 308 9 interested interested JJ cord-018017-c8myq6bi 308 10 in in IN cord-018017-c8myq6bi 308 11 finding find VBG cord-018017-c8myq6bi 308 12 an an DT cord-018017-c8myq6bi 308 13 antiviral antiviral JJ cord-018017-c8myq6bi 308 14 agent agent NN cord-018017-c8myq6bi 308 15 for for IN cord-018017-c8myq6bi 308 16 these these DT cord-018017-c8myq6bi 308 17 viruses virus NNS cord-018017-c8myq6bi 308 18 . . . cord-018017-c8myq6bi 309 1 My -PRON- PRP$ cord-018017-c8myq6bi 309 2 prime prime JJ cord-018017-c8myq6bi 309 3 directive directive NN cord-018017-c8myq6bi 309 4 at at IN cord-018017-c8myq6bi 309 5 AVI AVI NNP cord-018017-c8myq6bi 309 6 BioPharma BioPharma NNP cord-018017-c8myq6bi 309 7 was be VBD cord-018017-c8myq6bi 309 8 to to TO cord-018017-c8myq6bi 309 9 explore explore VB cord-018017-c8myq6bi 309 10 the the DT cord-018017-c8myq6bi 309 11 capabilities capability NNS cord-018017-c8myq6bi 309 12 of of IN cord-018017-c8myq6bi 309 13 our -PRON- PRP$ cord-018017-c8myq6bi 309 14 proprietary proprietary JJ cord-018017-c8myq6bi 309 15 antisense antisense NN cord-018017-c8myq6bi 309 16 technology technology NN cord-018017-c8myq6bi 310 1 and and CC cord-018017-c8myq6bi 310 2 I -PRON- PRP cord-018017-c8myq6bi 310 3 had have VBD cord-018017-c8myq6bi 310 4 yet yet RB cord-018017-c8myq6bi 310 5 to to TO cord-018017-c8myq6bi 310 6 investigate investigate VB cord-018017-c8myq6bi 310 7 targeting target VBG cord-018017-c8myq6bi 310 8 a a DT cord-018017-c8myq6bi 310 9 virus virus NN cord-018017-c8myq6bi 310 10 . . . cord-018017-c8myq6bi 311 1 The the DT cord-018017-c8myq6bi 311 2 caliciviruses caliciviruse NNS cord-018017-c8myq6bi 311 3 have have VBP cord-018017-c8myq6bi 311 4 positive positive JJ cord-018017-c8myq6bi 311 5 sense sense NN cord-018017-c8myq6bi 311 6 single single RB cord-018017-c8myq6bi 311 7 - - HYPH cord-018017-c8myq6bi 311 8 stranded strand VBN cord-018017-c8myq6bi 311 9 RNA RNA NNP cord-018017-c8myq6bi 311 10 genomes genome NNS cord-018017-c8myq6bi 311 11 which which WDT cord-018017-c8myq6bi 311 12 express express VBP cord-018017-c8myq6bi 311 13 three three CD cord-018017-c8myq6bi 311 14 genes gene NNS cord-018017-c8myq6bi 311 15 from from IN cord-018017-c8myq6bi 311 16 a a DT cord-018017-c8myq6bi 311 17 single single JJ cord-018017-c8myq6bi 311 18 polyprotein polyprotein NN cord-018017-c8myq6bi 311 19 . . . cord-018017-c8myq6bi 312 1 We -PRON- PRP cord-018017-c8myq6bi 312 2 identified identify VBD cord-018017-c8myq6bi 312 3 an an DT cord-018017-c8myq6bi 312 4 active active JJ cord-018017-c8myq6bi 312 5 agent agent NN cord-018017-c8myq6bi 312 6 following follow VBG cord-018017-c8myq6bi 312 7 an an DT cord-018017-c8myq6bi 312 8 investigation investigation NN cord-018017-c8myq6bi 312 9 with with IN cord-018017-c8myq6bi 312 10 small small JJ cord-018017-c8myq6bi 312 11 collection collection NN cord-018017-c8myq6bi 312 12 of of IN cord-018017-c8myq6bi 312 13 candidates candidate NNS cord-018017-c8myq6bi 312 14 ( ( -LRB- cord-018017-c8myq6bi 312 15 Stein Stein NNP cord-018017-c8myq6bi 312 16 et et NNP cord-018017-c8myq6bi 312 17 al al NNP cord-018017-c8myq6bi 312 18 . . NNP cord-018017-c8myq6bi 312 19 2001 2001 CD cord-018017-c8myq6bi 312 20 ) ) -RRB- cord-018017-c8myq6bi 312 21 . . . cord-018017-c8myq6bi 313 1 The the DT cord-018017-c8myq6bi 313 2 vesivirus vesivirus JJ cord-018017-c8myq6bi 313 3 group group NN cord-018017-c8myq6bi 313 4 of of IN cord-018017-c8myq6bi 313 5 caliciviruses caliciviruse NNS cord-018017-c8myq6bi 313 6 are be VBP cord-018017-c8myq6bi 313 7 considered consider VBN cord-018017-c8myq6bi 313 8 animal animal NN cord-018017-c8myq6bi 313 9 only only RB cord-018017-c8myq6bi 313 10 and and CC cord-018017-c8myq6bi 313 11 are be VBP cord-018017-c8myq6bi 313 12 not not RB cord-018017-c8myq6bi 313 13 believed believe VBN cord-018017-c8myq6bi 313 14 to to TO cord-018017-c8myq6bi 313 15 infect infect VB cord-018017-c8myq6bi 313 16 humans human NNS cord-018017-c8myq6bi 313 17 but but CC cord-018017-c8myq6bi 313 18 Al Al NNP cord-018017-c8myq6bi 313 19 began begin VBD cord-018017-c8myq6bi 313 20 exploring explore VBG cord-018017-c8myq6bi 313 21 human human JJ cord-018017-c8myq6bi 313 22 samples sample NNS cord-018017-c8myq6bi 313 23 with with IN cord-018017-c8myq6bi 313 24 his -PRON- PRP$ cord-018017-c8myq6bi 313 25 collection collection NN cord-018017-c8myq6bi 313 26 of of IN cord-018017-c8myq6bi 313 27 detection detection NN cord-018017-c8myq6bi 313 28 reagents reagent NNS cord-018017-c8myq6bi 313 29 . . . cord-018017-c8myq6bi 314 1 After after IN cord-018017-c8myq6bi 314 2 several several JJ cord-018017-c8myq6bi 314 3 years year NNS cord-018017-c8myq6bi 314 4 making make VBG cord-018017-c8myq6bi 314 5 incremental incremental JJ cord-018017-c8myq6bi 314 6 progress progress NN cord-018017-c8myq6bi 314 7 , , , cord-018017-c8myq6bi 314 8 we -PRON- PRP cord-018017-c8myq6bi 314 9 found find VBD cord-018017-c8myq6bi 314 10 an an DT cord-018017-c8myq6bi 314 11 association association NN cord-018017-c8myq6bi 314 12 between between IN cord-018017-c8myq6bi 314 13 human human JJ cord-018017-c8myq6bi 314 14 blood blood NN cord-018017-c8myq6bi 314 15 samples sample NNS cord-018017-c8myq6bi 314 16 seropositive seropositive JJ cord-018017-c8myq6bi 314 17 for for IN cord-018017-c8myq6bi 314 18 vesivirus vesivirus NNP cord-018017-c8myq6bi 314 19 and and CC cord-018017-c8myq6bi 314 20 markers marker NNS cord-018017-c8myq6bi 314 21 of of IN cord-018017-c8myq6bi 314 22 liver liver NN cord-018017-c8myq6bi 314 23 disease disease NN cord-018017-c8myq6bi 315 1 ( ( -LRB- cord-018017-c8myq6bi 315 2 Smith Smith NNP cord-018017-c8myq6bi 315 3 et et NNP cord-018017-c8myq6bi 315 4 al al NNP cord-018017-c8myq6bi 315 5 . . . cord-018017-c8myq6bi 315 6 2006 2006 CD cord-018017-c8myq6bi 315 7 ) ) -RRB- cord-018017-c8myq6bi 315 8 . . . cord-018017-c8myq6bi 316 1 We -PRON- PRP cord-018017-c8myq6bi 316 2 felt feel VBD cord-018017-c8myq6bi 316 3 this this DT cord-018017-c8myq6bi 316 4 evidence evidence NN cord-018017-c8myq6bi 316 5 of of IN cord-018017-c8myq6bi 316 6 an an DT cord-018017-c8myq6bi 316 7 emerging emerge VBG cord-018017-c8myq6bi 316 8 infectious infectious JJ cord-018017-c8myq6bi 316 9 disease disease NN cord-018017-c8myq6bi 316 10 in in IN cord-018017-c8myq6bi 316 11 humans human NNS cord-018017-c8myq6bi 316 12 and and CC cord-018017-c8myq6bi 316 13 its -PRON- PRP$ cord-018017-c8myq6bi 316 14 potential potential NN cord-018017-c8myq6bi 316 15 to to TO cord-018017-c8myq6bi 316 16 cause cause VB cord-018017-c8myq6bi 316 17 liver liver NN cord-018017-c8myq6bi 316 18 disease disease NN cord-018017-c8myq6bi 316 19 would would MD cord-018017-c8myq6bi 316 20 be be VB cord-018017-c8myq6bi 316 21 welcomed welcome VBN cord-018017-c8myq6bi 316 22 by by IN cord-018017-c8myq6bi 316 23 the the DT cord-018017-c8myq6bi 316 24 medical medical JJ cord-018017-c8myq6bi 316 25 community community NN cord-018017-c8myq6bi 316 26 . . . cord-018017-c8myq6bi 317 1 Al Al NNP cord-018017-c8myq6bi 317 2 and and CC cord-018017-c8myq6bi 317 3 I -PRON- PRP cord-018017-c8myq6bi 317 4 made make VBD cord-018017-c8myq6bi 317 5 a a DT cord-018017-c8myq6bi 317 6 trip trip NN cord-018017-c8myq6bi 317 7 to to IN cord-018017-c8myq6bi 317 8 Washington Washington NNP cord-018017-c8myq6bi 317 9 DC DC NNP cord-018017-c8myq6bi 317 10 at at IN cord-018017-c8myq6bi 317 11 our -PRON- PRP$ cord-018017-c8myq6bi 317 12 own own JJ cord-018017-c8myq6bi 317 13 expense expense NN cord-018017-c8myq6bi 317 14 to to TO cord-018017-c8myq6bi 317 15 relate relate VB cord-018017-c8myq6bi 317 16 the the DT cord-018017-c8myq6bi 317 17 findings finding NNS cord-018017-c8myq6bi 317 18 in in IN cord-018017-c8myq6bi 317 19 person person NN cord-018017-c8myq6bi 317 20 . . . cord-018017-c8myq6bi 318 1 We -PRON- PRP cord-018017-c8myq6bi 318 2 meet meet VBP cord-018017-c8myq6bi 318 3 with with IN cord-018017-c8myq6bi 318 4 virologists virologist NNS cord-018017-c8myq6bi 318 5 at at IN cord-018017-c8myq6bi 318 6 the the DT cord-018017-c8myq6bi 318 7 National National NNP cord-018017-c8myq6bi 318 8 Institutes Institutes NNPS cord-018017-c8myq6bi 318 9 of of IN cord-018017-c8myq6bi 318 10 Health Health NNP cord-018017-c8myq6bi 318 11 but but CC cord-018017-c8myq6bi 318 12 were be VBD cord-018017-c8myq6bi 318 13 met meet VBN cord-018017-c8myq6bi 318 14 with with IN cord-018017-c8myq6bi 318 15 judicious judicious JJ cord-018017-c8myq6bi 318 16 skepticism skepticism NN cord-018017-c8myq6bi 318 17 . . . cord-018017-c8myq6bi 319 1 Harvey Harvey NNP cord-018017-c8myq6bi 319 2 Alter Alter NNP cord-018017-c8myq6bi 319 3 had have VBD cord-018017-c8myq6bi 319 4 been be VBN cord-018017-c8myq6bi 319 5 instrumental instrumental JJ cord-018017-c8myq6bi 319 6 in in IN cord-018017-c8myq6bi 319 7 the the DT cord-018017-c8myq6bi 319 8 discovery discovery NN cord-018017-c8myq6bi 319 9 of of IN cord-018017-c8myq6bi 319 10 Hepatitis Hepatitis NNP cord-018017-c8myq6bi 319 11 C C NNP cord-018017-c8myq6bi 319 12 Virus Virus NNP cord-018017-c8myq6bi 319 13 ( ( -LRB- cord-018017-c8myq6bi 319 14 HCV HCV NNP cord-018017-c8myq6bi 319 15 ) ) -RRB- cord-018017-c8myq6bi 319 16 and and CC cord-018017-c8myq6bi 319 17 felt feel VBD cord-018017-c8myq6bi 319 18 all all DT cord-018017-c8myq6bi 319 19 viral viral JJ cord-018017-c8myq6bi 319 20 liver liver NN cord-018017-c8myq6bi 319 21 disease disease NN cord-018017-c8myq6bi 319 22 is be VBZ cord-018017-c8myq6bi 319 23 already already RB cord-018017-c8myq6bi 319 24 accounted account VBN cord-018017-c8myq6bi 319 25 for for IN cord-018017-c8myq6bi 319 26 by by IN cord-018017-c8myq6bi 319 27 hepatitis hepatitis NN cord-018017-c8myq6bi 319 28 viruses virus NNS cord-018017-c8myq6bi 319 29 . . . cord-018017-c8myq6bi 320 1 Hence hence RB cord-018017-c8myq6bi 320 2 , , , cord-018017-c8myq6bi 320 3 no no DT cord-018017-c8myq6bi 320 4 interest interest NN cord-018017-c8myq6bi 320 5 in in IN cord-018017-c8myq6bi 320 6 our -PRON- PRP$ cord-018017-c8myq6bi 320 7 findings finding NNS cord-018017-c8myq6bi 320 8 . . . cord-018017-c8myq6bi 321 1 We -PRON- PRP cord-018017-c8myq6bi 321 2 met meet VBD cord-018017-c8myq6bi 321 3 with with IN cord-018017-c8myq6bi 321 4 the the DT cord-018017-c8myq6bi 321 5 American American NNP cord-018017-c8myq6bi 321 6 Red Red NNP cord-018017-c8myq6bi 321 7 Cross Cross NNP cord-018017-c8myq6bi 321 8 blood blood NN cord-018017-c8myq6bi 321 9 banking banking NN cord-018017-c8myq6bi 321 10 group group NN cord-018017-c8myq6bi 321 11 in in IN cord-018017-c8myq6bi 321 12 Shady Shady NNP cord-018017-c8myq6bi 321 13 Grove Grove NNP cord-018017-c8myq6bi 321 14 Maryland Maryland NNP cord-018017-c8myq6bi 321 15 and and CC cord-018017-c8myq6bi 321 16 were be VBD cord-018017-c8myq6bi 321 17 met meet VBN cord-018017-c8myq6bi 321 18 with with IN cord-018017-c8myq6bi 321 19 concern concern NN cord-018017-c8myq6bi 321 20 . . . cord-018017-c8myq6bi 322 1 Blood blood NN cord-018017-c8myq6bi 322 2 supplies supply NNS cord-018017-c8myq6bi 322 3 are be VBP cord-018017-c8myq6bi 322 4 scrutinized scrutinize VBN cord-018017-c8myq6bi 322 5 by by IN cord-018017-c8myq6bi 322 6 the the DT cord-018017-c8myq6bi 322 7 nucleic nucleic JJ cord-018017-c8myq6bi 322 8 acid acid NN cord-018017-c8myq6bi 322 9 test test NN cord-018017-c8myq6bi 322 10 ( ( -LRB- cord-018017-c8myq6bi 322 11 NAT NAT NNP cord-018017-c8myq6bi 322 12 ) ) -RRB- cord-018017-c8myq6bi 322 13 to to TO cord-018017-c8myq6bi 322 14 eliminate eliminate VB cord-018017-c8myq6bi 322 15 viral viral JJ cord-018017-c8myq6bi 322 16 contamination contamination NN cord-018017-c8myq6bi 322 17 and and CC cord-018017-c8myq6bi 322 18 any any DT cord-018017-c8myq6bi 322 19 further further JJ cord-018017-c8myq6bi 322 20 elimination elimination NN cord-018017-c8myq6bi 322 21 of of IN cord-018017-c8myq6bi 322 22 blood blood NN cord-018017-c8myq6bi 322 23 samples sample NNS cord-018017-c8myq6bi 322 24 would would MD cord-018017-c8myq6bi 322 25 threaten threaten VB cord-018017-c8myq6bi 322 26 an an DT cord-018017-c8myq6bi 322 27 already already RB cord-018017-c8myq6bi 322 28 limited limit VBN cord-018017-c8myq6bi 322 29 inventory inventory NN cord-018017-c8myq6bi 322 30 . . . cord-018017-c8myq6bi 323 1 Our -PRON- PRP$ cord-018017-c8myq6bi 323 2 findings finding NNS cord-018017-c8myq6bi 323 3 simply simply RB cord-018017-c8myq6bi 323 4 add add VBP cord-018017-c8myq6bi 323 5 complication complication NN cord-018017-c8myq6bi 323 6 to to IN cord-018017-c8myq6bi 323 7 the the DT cord-018017-c8myq6bi 323 8 blood blood NN cord-018017-c8myq6bi 323 9 supply supply NN cord-018017-c8myq6bi 323 10 Finding find VBG cord-018017-c8myq6bi 323 11 an an DT cord-018017-c8myq6bi 323 12 Emerging emerge VBG cord-018017-c8myq6bi 323 13 Infectious Infectious NNP cord-018017-c8myq6bi 323 14 Disease Disease NNP cord-018017-c8myq6bi 323 15 business business NN cord-018017-c8myq6bi 323 16 . . . cord-018017-c8myq6bi 324 1 They -PRON- PRP cord-018017-c8myq6bi 324 2 asked ask VBD cord-018017-c8myq6bi 324 3 for for IN cord-018017-c8myq6bi 324 4 more more RBR cord-018017-c8myq6bi 324 5 compelling compelling JJ cord-018017-c8myq6bi 324 6 and and CC cord-018017-c8myq6bi 324 7 more more RBR cord-018017-c8myq6bi 324 8 extensive extensive JJ cord-018017-c8myq6bi 324 9 data datum NNS cord-018017-c8myq6bi 324 10 to to TO cord-018017-c8myq6bi 324 11 add add VB cord-018017-c8myq6bi 324 12 robustness robustness NN cord-018017-c8myq6bi 324 13 to to IN cord-018017-c8myq6bi 324 14 our -PRON- PRP$ cord-018017-c8myq6bi 324 15 claims claim NNS cord-018017-c8myq6bi 324 16 . . . cord-018017-c8myq6bi 325 1 The the DT cord-018017-c8myq6bi 325 2 only only JJ cord-018017-c8myq6bi 325 3 problem problem NN cord-018017-c8myq6bi 325 4 is be VBZ cord-018017-c8myq6bi 325 5 that that IN cord-018017-c8myq6bi 325 6 they -PRON- PRP cord-018017-c8myq6bi 325 7 were be VBD cord-018017-c8myq6bi 325 8 not not RB cord-018017-c8myq6bi 325 9 interested interested JJ cord-018017-c8myq6bi 325 10 in in IN cord-018017-c8myq6bi 325 11 providing provide VBG cord-018017-c8myq6bi 325 12 financial financial JJ cord-018017-c8myq6bi 325 13 support support NN cord-018017-c8myq6bi 325 14 for for IN cord-018017-c8myq6bi 325 15 the the DT cord-018017-c8myq6bi 325 16 recommended recommend VBN cord-018017-c8myq6bi 325 17 studies study NNS cord-018017-c8myq6bi 325 18 . . . cord-018017-c8myq6bi 326 1 The the DT cord-018017-c8myq6bi 326 2 conundrum conundrum NN cord-018017-c8myq6bi 326 3 is be VBZ cord-018017-c8myq6bi 326 4 all all RB cord-018017-c8myq6bi 326 5 too too RB cord-018017-c8myq6bi 326 6 common common JJ cord-018017-c8myq6bi 326 7 , , , cord-018017-c8myq6bi 326 8 you -PRON- PRP cord-018017-c8myq6bi 326 9 need need VBP cord-018017-c8myq6bi 326 10 more more JJR cord-018017-c8myq6bi 326 11 data datum NNS cord-018017-c8myq6bi 326 12 to to TO cord-018017-c8myq6bi 326 13 convince convince VB cord-018017-c8myq6bi 326 14 granting grant VBG cord-018017-c8myq6bi 326 15 agencies agency NNS cord-018017-c8myq6bi 326 16 to to TO cord-018017-c8myq6bi 326 17 support support VB cord-018017-c8myq6bi 326 18 the the DT cord-018017-c8myq6bi 326 19 work work NN cord-018017-c8myq6bi 326 20 but but CC cord-018017-c8myq6bi 326 21 there there EX cord-018017-c8myq6bi 326 22 is be VBZ cord-018017-c8myq6bi 326 23 no no DT cord-018017-c8myq6bi 326 24 support support NN cord-018017-c8myq6bi 326 25 to to TO cord-018017-c8myq6bi 326 26 add add VB cord-018017-c8myq6bi 326 27 to to IN cord-018017-c8myq6bi 326 28 the the DT cord-018017-c8myq6bi 326 29 limited limited JJ cord-018017-c8myq6bi 326 30 data datum NNS cord-018017-c8myq6bi 326 31 . . . cord-018017-c8myq6bi 327 1 Life life NN cord-018017-c8myq6bi 327 2 on on IN cord-018017-c8myq6bi 327 3 the the DT cord-018017-c8myq6bi 327 4 cutting cutting NN cord-018017-c8myq6bi 327 5 edge edge NN cord-018017-c8myq6bi 327 6 is be VBZ cord-018017-c8myq6bi 327 7 frequently frequently RB cord-018017-c8myq6bi 327 8 discouraging discourage VBG cord-018017-c8myq6bi 327 9 . . . cord-018017-c8myq6bi 328 1 Our -PRON- PRP$ cord-018017-c8myq6bi 328 2 strategy strategy NN cord-018017-c8myq6bi 328 3 took take VBD cord-018017-c8myq6bi 328 4 two two CD cord-018017-c8myq6bi 328 5 paths path NNS cord-018017-c8myq6bi 328 6 : : : cord-018017-c8myq6bi 328 7 one one CD cord-018017-c8myq6bi 328 8 to to TO cord-018017-c8myq6bi 328 9 seek seek VB cord-018017-c8myq6bi 328 10 commercial commercial JJ cord-018017-c8myq6bi 328 11 support support NN cord-018017-c8myq6bi 328 12 and and CC cord-018017-c8myq6bi 328 13 the the DT cord-018017-c8myq6bi 328 14 other other JJ cord-018017-c8myq6bi 328 15 to to TO cord-018017-c8myq6bi 328 16 create create VB cord-018017-c8myq6bi 328 17 proof proof NN cord-018017-c8myq6bi 328 18 of of IN cord-018017-c8myq6bi 328 19 concept concept NN cord-018017-c8myq6bi 328 20 data datum NNS cord-018017-c8myq6bi 328 21 for for IN cord-018017-c8myq6bi 328 22 an an DT cord-018017-c8myq6bi 328 23 antiviral antiviral JJ cord-018017-c8myq6bi 328 24 solution solution NN cord-018017-c8myq6bi 328 25 . . . cord-018017-c8myq6bi 329 1 The the DT cord-018017-c8myq6bi 329 2 most most RBS cord-018017-c8myq6bi 329 3 logical logical JJ cord-018017-c8myq6bi 329 4 commercial commercial JJ cord-018017-c8myq6bi 329 5 solution solution NN cord-018017-c8myq6bi 329 6 was be VBD cord-018017-c8myq6bi 329 7 to to TO cord-018017-c8myq6bi 329 8 meet meet VB cord-018017-c8myq6bi 329 9 with with IN cord-018017-c8myq6bi 329 10 Michael Michael NNP cord-018017-c8myq6bi 329 11 Houghton Houghton NNP cord-018017-c8myq6bi 329 12 at at IN cord-018017-c8myq6bi 329 13 Chiron Chiron NNP cord-018017-c8myq6bi 329 14 . . . cord-018017-c8myq6bi 330 1 He -PRON- PRP cord-018017-c8myq6bi 330 2 was be VBD cord-018017-c8myq6bi 330 3 the the DT cord-018017-c8myq6bi 330 4 driving drive VBG cord-018017-c8myq6bi 330 5 scientific scientific JJ cord-018017-c8myq6bi 330 6 force force NN cord-018017-c8myq6bi 330 7 in in IN cord-018017-c8myq6bi 330 8 finding find VBG cord-018017-c8myq6bi 330 9 HCV HCV NNP cord-018017-c8myq6bi 330 10 and and CC cord-018017-c8myq6bi 330 11 Chiron Chiron NNP cord-018017-c8myq6bi 330 12 might may MD cord-018017-c8myq6bi 330 13 like like VB cord-018017-c8myq6bi 330 14 adding add VBG cord-018017-c8myq6bi 330 15 to to IN cord-018017-c8myq6bi 330 16 their -PRON- PRP$ cord-018017-c8myq6bi 330 17 reputation reputation NN cord-018017-c8myq6bi 330 18 by by IN cord-018017-c8myq6bi 330 19 finding find VBG cord-018017-c8myq6bi 330 20 another another DT cord-018017-c8myq6bi 330 21 previously previously RB cord-018017-c8myq6bi 330 22 unrecognized unrecognized JJ cord-018017-c8myq6bi 330 23 hepatitis hepatitis NN cord-018017-c8myq6bi 330 24 virus virus NN cord-018017-c8myq6bi 330 25 . . . cord-018017-c8myq6bi 331 1 Indeed indeed RB cord-018017-c8myq6bi 331 2 , , , cord-018017-c8myq6bi 331 3 Dr. Dr. NNP cord-018017-c8myq6bi 331 4 Houghton Houghton NNP cord-018017-c8myq6bi 331 5 invited invite VBD cord-018017-c8myq6bi 331 6 us -PRON- PRP cord-018017-c8myq6bi 331 7 to to IN cord-018017-c8myq6bi 331 8 bay bay NNP cord-018017-c8myq6bi 331 9 area area NN cord-018017-c8myq6bi 331 10 to to TO cord-018017-c8myq6bi 331 11 discuss discuss VB cord-018017-c8myq6bi 331 12 the the DT cord-018017-c8myq6bi 331 13 project project NN cord-018017-c8myq6bi 331 14 . . . cord-018017-c8myq6bi 332 1 He -PRON- PRP cord-018017-c8myq6bi 332 2 reviewed review VBD cord-018017-c8myq6bi 332 3 our -PRON- PRP$ cord-018017-c8myq6bi 332 4 data datum NNS cord-018017-c8myq6bi 332 5 and and CC cord-018017-c8myq6bi 332 6 the the DT cord-018017-c8myq6bi 332 7 quality quality NN cord-018017-c8myq6bi 332 8 of of IN cord-018017-c8myq6bi 332 9 Al Al NNP cord-018017-c8myq6bi 332 10 's 's POS cord-018017-c8myq6bi 332 11 detection detection NN cord-018017-c8myq6bi 332 12 reagents reagent NNS cord-018017-c8myq6bi 332 13 . . . cord-018017-c8myq6bi 333 1 Chiron Chiron NNP cord-018017-c8myq6bi 333 2 provided provide VBD cord-018017-c8myq6bi 333 3 modest modest JJ cord-018017-c8myq6bi 333 4 support support NN cord-018017-c8myq6bi 333 5 and and CC cord-018017-c8myq6bi 333 6 their -PRON- PRP$ cord-018017-c8myq6bi 333 7 in in IN cord-018017-c8myq6bi 333 8 - - HYPH cord-018017-c8myq6bi 333 9 house house NN cord-018017-c8myq6bi 333 10 laboratory laboratory NN cord-018017-c8myq6bi 333 11 help help NN cord-018017-c8myq6bi 333 12 to to TO cord-018017-c8myq6bi 333 13 confirm confirm VB cord-018017-c8myq6bi 333 14 our -PRON- PRP$ cord-018017-c8myq6bi 333 15 observations observation NNS cord-018017-c8myq6bi 333 16 , , , cord-018017-c8myq6bi 333 17 a a DT cord-018017-c8myq6bi 333 18 glimmer glimmer NN cord-018017-c8myq6bi 333 19 of of IN cord-018017-c8myq6bi 333 20 hope hope NN cord-018017-c8myq6bi 333 21 . . . cord-018017-c8myq6bi 334 1 Al Al NNP cord-018017-c8myq6bi 334 2 created create VBD cord-018017-c8myq6bi 334 3 a a DT cord-018017-c8myq6bi 334 4 company company NN cord-018017-c8myq6bi 334 5 , , , cord-018017-c8myq6bi 334 6 Calicitech Calicitech NNP cord-018017-c8myq6bi 334 7 , , , cord-018017-c8myq6bi 334 8 so so IN cord-018017-c8myq6bi 334 9 that that IN cord-018017-c8myq6bi 334 10 he -PRON- PRP cord-018017-c8myq6bi 334 11 could could MD cord-018017-c8myq6bi 334 12 accept accept VB cord-018017-c8myq6bi 334 13 support support NN cord-018017-c8myq6bi 334 14 and and CC cord-018017-c8myq6bi 334 15 license license VB cord-018017-c8myq6bi 334 16 his -PRON- PRP$ cord-018017-c8myq6bi 334 17 reagent reagent NN cord-018017-c8myq6bi 334 18 patents patent NNS cord-018017-c8myq6bi 334 19 from from IN cord-018017-c8myq6bi 334 20 the the DT cord-018017-c8myq6bi 334 21 university university NN cord-018017-c8myq6bi 334 22 . . . cord-018017-c8myq6bi 335 1 Testing test VBG cord-018017-c8myq6bi 335 2 an an DT cord-018017-c8myq6bi 335 3 antiviral antiviral JJ cord-018017-c8myq6bi 335 4 agent agent NN cord-018017-c8myq6bi 335 5 in in IN cord-018017-c8myq6bi 335 6 humans human NNS cord-018017-c8myq6bi 335 7 would would MD cord-018017-c8myq6bi 335 8 be be VB cord-018017-c8myq6bi 335 9 expensive expensive JJ cord-018017-c8myq6bi 335 10 but but CC cord-018017-c8myq6bi 335 11 in in IN cord-018017-c8myq6bi 335 12 the the DT cord-018017-c8myq6bi 335 13 absence absence NN cord-018017-c8myq6bi 335 14 of of IN cord-018017-c8myq6bi 335 15 natural natural JJ cord-018017-c8myq6bi 335 16 history history NN cord-018017-c8myq6bi 335 17 of of IN cord-018017-c8myq6bi 335 18 the the DT cord-018017-c8myq6bi 335 19 infection infection NN cord-018017-c8myq6bi 335 20 would would MD cord-018017-c8myq6bi 335 21 make make VB cord-018017-c8myq6bi 335 22 human human JJ cord-018017-c8myq6bi 335 23 proof proof NN cord-018017-c8myq6bi 335 24 of of IN cord-018017-c8myq6bi 335 25 concept concept NN cord-018017-c8myq6bi 335 26 impossible impossible JJ cord-018017-c8myq6bi 335 27 . . . cord-018017-c8myq6bi 336 1 However however RB cord-018017-c8myq6bi 336 2 , , , cord-018017-c8myq6bi 336 3 Al Al NNP cord-018017-c8myq6bi 336 4 had have VBD cord-018017-c8myq6bi 336 5 been be VBN cord-018017-c8myq6bi 336 6 contacted contact VBN cord-018017-c8myq6bi 336 7 by by IN cord-018017-c8myq6bi 336 8 a a DT cord-018017-c8myq6bi 336 9 cat cat NN cord-018017-c8myq6bi 336 10 rescue rescue NN cord-018017-c8myq6bi 336 11 facility facility NN cord-018017-c8myq6bi 336 12 in in IN cord-018017-c8myq6bi 336 13 Atlanta Atlanta NNP cord-018017-c8myq6bi 336 14 , , , cord-018017-c8myq6bi 336 15 Mommy Mommy NNP cord-018017-c8myq6bi 336 16 Cat Cat NNP cord-018017-c8myq6bi 336 17 , , , cord-018017-c8myq6bi 336 18 describing describe VBG cord-018017-c8myq6bi 336 19 an an DT cord-018017-c8myq6bi 336 20 outbreak outbreak NN cord-018017-c8myq6bi 336 21 of of IN cord-018017-c8myq6bi 336 22 feline feline JJ cord-018017-c8myq6bi 336 23 calicivirus calicivirus NNP cord-018017-c8myq6bi 336 24 ( ( -LRB- cord-018017-c8myq6bi 336 25 FeCV FeCV NNP cord-018017-c8myq6bi 336 26 ) ) -RRB- cord-018017-c8myq6bi 336 27 in in IN cord-018017-c8myq6bi 336 28 their -PRON- PRP$ cord-018017-c8myq6bi 336 29 cattery cattery NN cord-018017-c8myq6bi 336 30 . . . cord-018017-c8myq6bi 337 1 These these DT cord-018017-c8myq6bi 337 2 cats cat NNS cord-018017-c8myq6bi 337 3 had have VBD cord-018017-c8myq6bi 337 4 all all DT cord-018017-c8myq6bi 337 5 been be VBN cord-018017-c8myq6bi 337 6 vaccinated vaccinate VBN cord-018017-c8myq6bi 337 7 with with IN cord-018017-c8myq6bi 337 8 an an DT cord-018017-c8myq6bi 337 9 approved approve VBN cord-018017-c8myq6bi 337 10 FeCV FeCV NNP cord-018017-c8myq6bi 337 11 vaccine vaccine NN cord-018017-c8myq6bi 337 12 which which WDT cord-018017-c8myq6bi 337 13 failed fail VBD cord-018017-c8myq6bi 337 14 to to TO cord-018017-c8myq6bi 337 15 protect protect VB cord-018017-c8myq6bi 337 16 these these DT cord-018017-c8myq6bi 337 17 cats cat NNS cord-018017-c8myq6bi 337 18 . . . cord-018017-c8myq6bi 338 1 A a DT cord-018017-c8myq6bi 338 2 veterinarian veterinarian NN cord-018017-c8myq6bi 338 3 can can MD cord-018017-c8myq6bi 338 4 decide decide VB cord-018017-c8myq6bi 338 5 to to TO cord-018017-c8myq6bi 338 6 use use VB cord-018017-c8myq6bi 338 7 alternative alternative JJ cord-018017-c8myq6bi 338 8 medicines medicine NNS cord-018017-c8myq6bi 338 9 if if IN cord-018017-c8myq6bi 338 10 there there EX cord-018017-c8myq6bi 338 11 are be VBP cord-018017-c8myq6bi 338 12 no no DT cord-018017-c8myq6bi 338 13 alternatives alternative NNS cord-018017-c8myq6bi 338 14 and and CC cord-018017-c8myq6bi 338 15 the the DT cord-018017-c8myq6bi 338 16 owner owner NN cord-018017-c8myq6bi 338 17 oc oc XX cord-018017-c8myq6bi 338 18 the the DT cord-018017-c8myq6bi 338 19 cats cat NNS cord-018017-c8myq6bi 338 20 can can MD cord-018017-c8myq6bi 338 21 sign sign VB cord-018017-c8myq6bi 338 22 the the DT cord-018017-c8myq6bi 338 23 equivalent equivalent NN cord-018017-c8myq6bi 338 24 of of IN cord-018017-c8myq6bi 338 25 informed informed JJ cord-018017-c8myq6bi 338 26 consent consent NN cord-018017-c8myq6bi 338 27 . . . cord-018017-c8myq6bi 339 1 We -PRON- PRP cord-018017-c8myq6bi 339 2 provided provide VBD cord-018017-c8myq6bi 339 3 our -PRON- PRP$ cord-018017-c8myq6bi 339 4 FeCV FeCV NNP cord-018017-c8myq6bi 339 5 specific specific JJ cord-018017-c8myq6bi 339 6 antiviral antiviral JJ cord-018017-c8myq6bi 339 7 to to IN cord-018017-c8myq6bi 339 8 Mommy Mommy NNP cord-018017-c8myq6bi 339 9 Cat Cat NNP cord-018017-c8myq6bi 339 10 along along RP cord-018017-c8myq6bi 339 11 with with IN cord-018017-c8myq6bi 339 12 a a DT cord-018017-c8myq6bi 339 13 detailed detailed JJ cord-018017-c8myq6bi 339 14 protocol protocol NN cord-018017-c8myq6bi 339 15 for for IN cord-018017-c8myq6bi 339 16 treatment treatment NN cord-018017-c8myq6bi 339 17 . . . cord-018017-c8myq6bi 340 1 The the DT cord-018017-c8myq6bi 340 2 infected infected JJ cord-018017-c8myq6bi 340 3 kittens kitten NNS cord-018017-c8myq6bi 340 4 we -PRON- PRP cord-018017-c8myq6bi 340 5 treated treat VBN cord-018017-c8myq6bi 340 6 survived survive VBD cord-018017-c8myq6bi 340 7 while while IN cord-018017-c8myq6bi 340 8 those those DT cord-018017-c8myq6bi 340 9 not not RB cord-018017-c8myq6bi 340 10 treated treat VBN cord-018017-c8myq6bi 340 11 died die VBD cord-018017-c8myq6bi 340 12 providing provide VBG cord-018017-c8myq6bi 340 13 encouraging encouraging JJ cord-018017-c8myq6bi 340 14 data datum NNS cord-018017-c8myq6bi 340 15 . . . cord-018017-c8myq6bi 341 1 We -PRON- PRP cord-018017-c8myq6bi 341 2 then then RB cord-018017-c8myq6bi 341 3 discovered discover VBD cord-018017-c8myq6bi 341 4 a a DT cord-018017-c8myq6bi 341 5 similar similar JJ cord-018017-c8myq6bi 341 6 outbreak outbreak NN cord-018017-c8myq6bi 341 7 in in IN cord-018017-c8myq6bi 341 8 the the DT cord-018017-c8myq6bi 341 9 humane humane JJ cord-018017-c8myq6bi 341 10 society society NN cord-018017-c8myq6bi 341 11 facility facility NN cord-018017-c8myq6bi 341 12 in in IN cord-018017-c8myq6bi 341 13 Eugene Eugene NNP cord-018017-c8myq6bi 341 14 Oregon Oregon NNP cord-018017-c8myq6bi 341 15 , , , cord-018017-c8myq6bi 341 16 our -PRON- PRP$ cord-018017-c8myq6bi 341 17 neighbors neighbor NNS cord-018017-c8myq6bi 341 18 . . . cord-018017-c8myq6bi 342 1 Again again RB cord-018017-c8myq6bi 342 2 , , , cord-018017-c8myq6bi 342 3 we -PRON- PRP cord-018017-c8myq6bi 342 4 reached reach VBD cord-018017-c8myq6bi 342 5 an an DT cord-018017-c8myq6bi 342 6 agreement agreement NN cord-018017-c8myq6bi 342 7 to to TO cord-018017-c8myq6bi 342 8 treat treat VB cord-018017-c8myq6bi 342 9 infected infected JJ cord-018017-c8myq6bi 342 10 kittens kitten NNS cord-018017-c8myq6bi 342 11 and and CC cord-018017-c8myq6bi 342 12 were be VBD cord-018017-c8myq6bi 342 13 successful successful JJ cord-018017-c8myq6bi 342 14 ) ) -RRB- cord-018017-c8myq6bi 342 15 . . . cord-018017-c8myq6bi 343 1 This this DT cord-018017-c8myq6bi 343 2 was be VBD cord-018017-c8myq6bi 343 3 the the DT cord-018017-c8myq6bi 343 4 first first JJ cord-018017-c8myq6bi 343 5 time time NN cord-018017-c8myq6bi 343 6 we -PRON- PRP cord-018017-c8myq6bi 343 7 treated treat VBD cord-018017-c8myq6bi 343 8 an an DT cord-018017-c8myq6bi 343 9 infection infection NN cord-018017-c8myq6bi 343 10 based base VBN cord-018017-c8myq6bi 343 11 on on IN cord-018017-c8myq6bi 343 12 symptoms symptom NNS cord-018017-c8myq6bi 343 13 in in IN cord-018017-c8myq6bi 343 14 an an DT cord-018017-c8myq6bi 343 15 " " `` cord-018017-c8myq6bi 343 16 outbread outbread JJ cord-018017-c8myq6bi 343 17 " " '' cord-018017-c8myq6bi 343 18 population population NN cord-018017-c8myq6bi 343 19 of of IN cord-018017-c8myq6bi 343 20 cats cat NNS cord-018017-c8myq6bi 343 21 . . . cord-018017-c8myq6bi 344 1 With with IN cord-018017-c8myq6bi 344 2 over over IN cord-018017-c8myq6bi 344 3 100 100 CD cord-018017-c8myq6bi 344 4 kitten kitten NN cord-018017-c8myq6bi 344 5 patients patient NNS cord-018017-c8myq6bi 344 6 and and CC cord-018017-c8myq6bi 344 7 remarkable remarkable JJ cord-018017-c8myq6bi 344 8 survival survival NN cord-018017-c8myq6bi 344 9 differences difference NNS cord-018017-c8myq6bi 344 10 between between IN cord-018017-c8myq6bi 344 11 treated treated JJ cord-018017-c8myq6bi 344 12 and and CC cord-018017-c8myq6bi 344 13 untreated untreated JJ cord-018017-c8myq6bi 344 14 , , , cord-018017-c8myq6bi 344 15 we -PRON- PRP cord-018017-c8myq6bi 344 16 had have VBD cord-018017-c8myq6bi 344 17 our -PRON- PRP$ cord-018017-c8myq6bi 344 18 proof proof NN cord-018017-c8myq6bi 344 19 of of IN cord-018017-c8myq6bi 344 20 concept concept NN cord-018017-c8myq6bi 344 21 . . . cord-018017-c8myq6bi 345 1 There there EX cord-018017-c8myq6bi 345 2 is be VBZ cord-018017-c8myq6bi 345 3 no no DT cord-018017-c8myq6bi 345 4 disease disease NN cord-018017-c8myq6bi 345 5 cluster cluster NN cord-018017-c8myq6bi 345 6 to to TO cord-018017-c8myq6bi 345 7 link link VB cord-018017-c8myq6bi 345 8 to to IN cord-018017-c8myq6bi 345 9 human human JJ cord-018017-c8myq6bi 345 10 vesivirus vesivirus NN cord-018017-c8myq6bi 345 11 . . . cord-018017-c8myq6bi 346 1 Norovirus norovirus NN cord-018017-c8myq6bi 346 2 is be VBZ cord-018017-c8myq6bi 346 3 a a DT cord-018017-c8myq6bi 346 4 calicivirus calicivirus NN cord-018017-c8myq6bi 346 5 and and CC cord-018017-c8myq6bi 346 6 is be VBZ cord-018017-c8myq6bi 346 7 known know VBN cord-018017-c8myq6bi 346 8 to to TO cord-018017-c8myq6bi 346 9 infect infect VB cord-018017-c8myq6bi 346 10 humans human NNS cord-018017-c8myq6bi 346 11 , , , cord-018017-c8myq6bi 346 12 in in IN cord-018017-c8myq6bi 346 13 fact fact NN cord-018017-c8myq6bi 346 14 it -PRON- PRP cord-018017-c8myq6bi 346 15 is be VBZ cord-018017-c8myq6bi 346 16 well well RB cord-018017-c8myq6bi 346 17 known know VBN cord-018017-c8myq6bi 346 18 on on IN cord-018017-c8myq6bi 346 19 cruise cruise NN cord-018017-c8myq6bi 346 20 ships ship NNS cord-018017-c8myq6bi 346 21 , , , cord-018017-c8myq6bi 346 22 day day NN cord-018017-c8myq6bi 346 23 care care NN cord-018017-c8myq6bi 346 24 centers center NNS cord-018017-c8myq6bi 346 25 , , , cord-018017-c8myq6bi 346 26 and and CC cord-018017-c8myq6bi 346 27 extended extended JJ cord-018017-c8myq6bi 346 28 care care NN cord-018017-c8myq6bi 346 29 retirement retirement NN cord-018017-c8myq6bi 346 30 facilities facility NNS cord-018017-c8myq6bi 346 31 . . . cord-018017-c8myq6bi 347 1 Our -PRON- PRP$ cord-018017-c8myq6bi 347 2 efforts effort NNS cord-018017-c8myq6bi 347 3 to to TO cord-018017-c8myq6bi 347 4 have have VB cord-018017-c8myq6bi 347 5 human human JJ cord-018017-c8myq6bi 347 6 vesivirus vesivirus NNP cord-018017-c8myq6bi 347 7 recognized recognize VBN cord-018017-c8myq6bi 347 8 as as IN cord-018017-c8myq6bi 347 9 an an DT cord-018017-c8myq6bi 347 10 emerging emerge VBG cord-018017-c8myq6bi 347 11 infectious infectious JJ cord-018017-c8myq6bi 347 12 disease disease NN cord-018017-c8myq6bi 347 13 have have VBP cord-018017-c8myq6bi 347 14 failed fail VBN cord-018017-c8myq6bi 347 15 . . . cord-018017-c8myq6bi 348 1 Chiron Chiron NNP cord-018017-c8myq6bi 348 2 was be VBD cord-018017-c8myq6bi 348 3 not not RB cord-018017-c8myq6bi 348 4 impressed impressed JJ cord-018017-c8myq6bi 348 5 with with IN cord-018017-c8myq6bi 348 6 our -PRON- PRP$ cord-018017-c8myq6bi 348 7 antiviral antiviral JJ cord-018017-c8myq6bi 348 8 and and CC cord-018017-c8myq6bi 348 9 no no RB cord-018017-c8myq6bi 348 10 longer long RBR cord-018017-c8myq6bi 348 11 were be VBD cord-018017-c8myq6bi 348 12 interested interested JJ cord-018017-c8myq6bi 348 13 in in IN cord-018017-c8myq6bi 348 14 evaluating evaluate VBG cord-018017-c8myq6bi 348 15 the the DT cord-018017-c8myq6bi 348 16 detection detection NN cord-018017-c8myq6bi 348 17 reagents reagent NNS cord-018017-c8myq6bi 348 18 . . . cord-018017-c8myq6bi 349 1 If if IN cord-018017-c8myq6bi 349 2 we -PRON- PRP cord-018017-c8myq6bi 349 3 are be VBP cord-018017-c8myq6bi 349 4 lucky lucky JJ cord-018017-c8myq6bi 349 5 , , , cord-018017-c8myq6bi 349 6 human human JJ cord-018017-c8myq6bi 349 7 vesivirus vesivirus NNP cord-018017-c8myq6bi 349 8 infections infection NNS cord-018017-c8myq6bi 349 9 will will MD cord-018017-c8myq6bi 349 10 remain remain VB cord-018017-c8myq6bi 349 11 mild mild JJ cord-018017-c8myq6bi 349 12 clinical clinical JJ cord-018017-c8myq6bi 349 13 oddities oddity NNS cord-018017-c8myq6bi 349 14 . . . cord-018017-c8myq6bi 350 1 Al Al NNP cord-018017-c8myq6bi 350 2 Smith Smith NNP cord-018017-c8myq6bi 350 3 has have VBZ cord-018017-c8myq6bi 350 4 an an DT cord-018017-c8myq6bi 350 5 interesting interesting JJ cord-018017-c8myq6bi 350 6 way way NN cord-018017-c8myq6bi 350 7 of of IN cord-018017-c8myq6bi 350 8 responding respond VBG cord-018017-c8myq6bi 350 9 , , , cord-018017-c8myq6bi 350 10 " " `` cord-018017-c8myq6bi 350 11 That that DT cord-018017-c8myq6bi 350 12 virus virus NN cord-018017-c8myq6bi 350 13 is be VBZ cord-018017-c8myq6bi 350 14 out out RB cord-018017-c8myq6bi 350 15 there there RB cord-018017-c8myq6bi 350 16 infecting infect VBG cord-018017-c8myq6bi 350 17 humans human NNS cord-018017-c8myq6bi 350 18 . . . cord-018017-c8myq6bi 351 1 It -PRON- PRP cord-018017-c8myq6bi 351 2 wo will MD cord-018017-c8myq6bi 351 3 n't not RB cord-018017-c8myq6bi 351 4 go go VB cord-018017-c8myq6bi 351 5 away away RB cord-018017-c8myq6bi 351 6 . . . cord-018017-c8myq6bi 352 1 " " '' cord-018017-c8myq6bi 353 1 The the DT cord-018017-c8myq6bi 353 2 existence existence NN cord-018017-c8myq6bi 353 3 of of IN cord-018017-c8myq6bi 353 4 non non JJ cord-018017-c8myq6bi 353 5 - - JJ cord-018017-c8myq6bi 353 6 pathogenic pathogenic JJ cord-018017-c8myq6bi 353 7 viral viral JJ cord-018017-c8myq6bi 353 8 infections infection NNS cord-018017-c8myq6bi 353 9 led lead VBN cord-018017-c8myq6bi 353 10 to to IN cord-018017-c8myq6bi 353 11 the the DT cord-018017-c8myq6bi 353 12 emergence emergence NN cord-018017-c8myq6bi 353 13 of of IN cord-018017-c8myq6bi 353 14 the the DT cord-018017-c8myq6bi 353 15 study study NN cord-018017-c8myq6bi 353 16 of of IN cord-018017-c8myq6bi 353 17 the the DT cord-018017-c8myq6bi 353 18 immune immune JJ cord-018017-c8myq6bi 353 19 system system NN cord-018017-c8myq6bi 353 20 , , , cord-018017-c8myq6bi 353 21 vaccination vaccination NN cord-018017-c8myq6bi 353 22 , , , cord-018017-c8myq6bi 353 23 gene gene NN cord-018017-c8myq6bi 353 24 therapy therapy NN cord-018017-c8myq6bi 353 25 , , , cord-018017-c8myq6bi 353 26 and and CC cord-018017-c8myq6bi 353 27 concern concern NN cord-018017-c8myq6bi 353 28 for for IN cord-018017-c8myq6bi 353 29 future future JJ cord-018017-c8myq6bi 353 30 pandemics pandemic NNS cord-018017-c8myq6bi 353 31 . . . cord-018017-c8myq6bi 354 1 We -PRON- PRP cord-018017-c8myq6bi 354 2 carry carry VBP cord-018017-c8myq6bi 354 3 evidence evidence NN cord-018017-c8myq6bi 354 4 of of IN cord-018017-c8myq6bi 354 5 ancient ancient JJ cord-018017-c8myq6bi 354 6 retroviral retroviral JJ cord-018017-c8myq6bi 354 7 infections infection NNS cord-018017-c8myq6bi 354 8 in in IN cord-018017-c8myq6bi 354 9 our -PRON- PRP$ cord-018017-c8myq6bi 354 10 genome genome NN cord-018017-c8myq6bi 354 11 from from IN cord-018017-c8myq6bi 354 12 integration integration NN cord-018017-c8myq6bi 354 13 events event NNS cord-018017-c8myq6bi 354 14 that that WDT cord-018017-c8myq6bi 354 15 became become VBD cord-018017-c8myq6bi 354 16 vertically vertically RB cord-018017-c8myq6bi 354 17 transmitted transmit VBN cord-018017-c8myq6bi 354 18 making making NN cord-018017-c8myq6bi 354 19 up up RP cord-018017-c8myq6bi 354 20 as as RB cord-018017-c8myq6bi 354 21 much much JJ cord-018017-c8myq6bi 354 22 as as IN cord-018017-c8myq6bi 354 23 8 8 CD cord-018017-c8myq6bi 354 24 percent percent NN cord-018017-c8myq6bi 354 25 of of IN cord-018017-c8myq6bi 354 26 the the DT cord-018017-c8myq6bi 354 27 human human JJ cord-018017-c8myq6bi 354 28 genome genome NN cord-018017-c8myq6bi 354 29 ( ( -LRB- cord-018017-c8myq6bi 354 30 Meyer Meyer NNP cord-018017-c8myq6bi 354 31 et et NNP cord-018017-c8myq6bi 354 32 al al NNP cord-018017-c8myq6bi 354 33 . . . cord-018017-c8myq6bi 354 34 2017 2017 CD cord-018017-c8myq6bi 354 35 ) ) -RRB- cord-018017-c8myq6bi 354 36 . . . cord-018017-c8myq6bi 355 1 These these DT cord-018017-c8myq6bi 355 2 genomic genomic JJ cord-018017-c8myq6bi 355 3 fossils fossil NNS cord-018017-c8myq6bi 355 4 are be VBP cord-018017-c8myq6bi 355 5 called call VBN cord-018017-c8myq6bi 355 6 endogenous endogenous JJ cord-018017-c8myq6bi 355 7 retroviral retroviral NN cord-018017-c8myq6bi 355 8 genomes genome NNS cord-018017-c8myq6bi 355 9 ( ( -LRB- cord-018017-c8myq6bi 355 10 ERV ERV NNP cord-018017-c8myq6bi 355 11 ) ) -RRB- cord-018017-c8myq6bi 355 12 . . . cord-018017-c8myq6bi 356 1 Most Most JJS cord-018017-c8myq6bi 356 2 ERV ERV NNP cord-018017-c8myq6bi 356 3 sequences sequence NNS cord-018017-c8myq6bi 356 4 accumulate accumulate VBP cord-018017-c8myq6bi 356 5 sufficient sufficient JJ cord-018017-c8myq6bi 356 6 mutations mutation NNS cord-018017-c8myq6bi 356 7 over over IN cord-018017-c8myq6bi 356 8 evolutionary evolutionary JJ cord-018017-c8myq6bi 356 9 time time NN cord-018017-c8myq6bi 356 10 that that WDT cord-018017-c8myq6bi 356 11 horizontal horizontal JJ cord-018017-c8myq6bi 356 12 transmission transmission NN cord-018017-c8myq6bi 356 13 is be VBZ cord-018017-c8myq6bi 356 14 unlikely unlikely JJ cord-018017-c8myq6bi 356 15 . . . cord-018017-c8myq6bi 357 1 These these DT cord-018017-c8myq6bi 357 2 viral viral JJ cord-018017-c8myq6bi 357 3 genome genome NN cord-018017-c8myq6bi 357 4 segments segment NNS cord-018017-c8myq6bi 357 5 are be VBP cord-018017-c8myq6bi 357 6 trapped trap VBN cord-018017-c8myq6bi 357 7 but but CC cord-018017-c8myq6bi 357 8 can can MD cord-018017-c8myq6bi 357 9 still still RB cord-018017-c8myq6bi 357 10 be be VB cord-018017-c8myq6bi 357 11 transcribed transcribe VBN cord-018017-c8myq6bi 357 12 and and CC cord-018017-c8myq6bi 357 13 encode encode VB cord-018017-c8myq6bi 357 14 some some DT cord-018017-c8myq6bi 357 15 viral viral JJ cord-018017-c8myq6bi 357 16 proteins protein NNS cord-018017-c8myq6bi 357 17 . . . cord-018017-c8myq6bi 358 1 The the DT cord-018017-c8myq6bi 358 2 significance significance NN cord-018017-c8myq6bi 358 3 of of IN cord-018017-c8myq6bi 358 4 these these DT cord-018017-c8myq6bi 358 5 integrated integrate VBN cord-018017-c8myq6bi 358 6 genomes genome NNS cord-018017-c8myq6bi 358 7 is be VBZ cord-018017-c8myq6bi 358 8 a a DT cord-018017-c8myq6bi 358 9 current current JJ cord-018017-c8myq6bi 358 10 topic topic NN cord-018017-c8myq6bi 358 11 of of IN cord-018017-c8myq6bi 358 12 investigation investigation NN cord-018017-c8myq6bi 358 13 . . . cord-018017-c8myq6bi 359 1 Adeno Adeno NNP cord-018017-c8myq6bi 359 2 - - HYPH cord-018017-c8myq6bi 359 3 associated associate VBN cord-018017-c8myq6bi 359 4 Virus Virus NNP cord-018017-c8myq6bi 359 5 ( ( -LRB- cord-018017-c8myq6bi 359 6 AAV AAV NNP cord-018017-c8myq6bi 359 7 ) ) -RRB- cord-018017-c8myq6bi 359 8 is be VBZ cord-018017-c8myq6bi 359 9 a a DT cord-018017-c8myq6bi 359 10 single single JJ cord-018017-c8myq6bi 359 11 stranded strand VBN cord-018017-c8myq6bi 359 12 DNA dna NN cord-018017-c8myq6bi 359 13 virus virus NN cord-018017-c8myq6bi 359 14 that that WDT cord-018017-c8myq6bi 359 15 infects infect VBZ cord-018017-c8myq6bi 359 16 humans human NNS cord-018017-c8myq6bi 359 17 but but CC cord-018017-c8myq6bi 359 18 are be VBP cord-018017-c8myq6bi 359 19 not not RB cord-018017-c8myq6bi 359 20 known know VBN cord-018017-c8myq6bi 359 21 to to TO cord-018017-c8myq6bi 359 22 cause cause VB cord-018017-c8myq6bi 359 23 disease disease NN cord-018017-c8myq6bi 359 24 . . . cord-018017-c8myq6bi 360 1 The the DT cord-018017-c8myq6bi 360 2 lack lack NN cord-018017-c8myq6bi 360 3 of of IN cord-018017-c8myq6bi 360 4 pathology pathology NN cord-018017-c8myq6bi 360 5 has have VBZ cord-018017-c8myq6bi 360 6 led lead VBN cord-018017-c8myq6bi 360 7 to to IN cord-018017-c8myq6bi 360 8 their -PRON- PRP$ cord-018017-c8myq6bi 360 9 use use NN cord-018017-c8myq6bi 360 10 as as IN cord-018017-c8myq6bi 360 11 viral viral JJ cord-018017-c8myq6bi 360 12 vectors vector NNS cord-018017-c8myq6bi 360 13 for for IN cord-018017-c8myq6bi 360 14 human human JJ cord-018017-c8myq6bi 360 15 gene gene NN cord-018017-c8myq6bi 360 16 therapy therapy NN cord-018017-c8myq6bi 360 17 . . . cord-018017-c8myq6bi 361 1 AAV AAV NNP cord-018017-c8myq6bi 361 2 can can MD cord-018017-c8myq6bi 361 3 infect infect VB cord-018017-c8myq6bi 361 4 dividing divide VBG cord-018017-c8myq6bi 361 5 and and CC cord-018017-c8myq6bi 361 6 quiescent quiescent JJ cord-018017-c8myq6bi 361 7 cells cell NNS cord-018017-c8myq6bi 361 8 and and CC cord-018017-c8myq6bi 361 9 will will MD cord-018017-c8myq6bi 361 10 persist persist VB cord-018017-c8myq6bi 361 11 extra extra RB cord-018017-c8myq6bi 361 12 chromosomally chromosomally RB cord-018017-c8myq6bi 361 13 without without IN cord-018017-c8myq6bi 361 14 integrating integrate VBG cord-018017-c8myq6bi 361 15 into into IN cord-018017-c8myq6bi 361 16 the the DT cord-018017-c8myq6bi 361 17 genome genome NN cord-018017-c8myq6bi 361 18 of of IN cord-018017-c8myq6bi 361 19 the the DT cord-018017-c8myq6bi 361 20 host host NN cord-018017-c8myq6bi 361 21 cell cell NN cord-018017-c8myq6bi 361 22 . . . cord-018017-c8myq6bi 362 1 AAV AAV NNP cord-018017-c8myq6bi 362 2 is be VBZ cord-018017-c8myq6bi 362 3 a a DT cord-018017-c8myq6bi 362 4 member member NN cord-018017-c8myq6bi 362 5 of of IN cord-018017-c8myq6bi 362 6 the the DT cord-018017-c8myq6bi 362 7 Parvoviridae Parvoviridae NNP cord-018017-c8myq6bi 362 8 family family NN cord-018017-c8myq6bi 362 9 in in IN cord-018017-c8myq6bi 362 10 the the DT cord-018017-c8myq6bi 362 11 genus genus NN cord-018017-c8myq6bi 362 12 Dependoparvovirus Dependoparvovirus NNP cord-018017-c8myq6bi 362 13 . . . cord-018017-c8myq6bi 363 1 is be VBZ cord-018017-c8myq6bi 363 2 an an DT cord-018017-c8myq6bi 363 3 Arenavirus Arenavirus NNP cord-018017-c8myq6bi 363 4 closely closely RB cord-018017-c8myq6bi 363 5 related relate VBN cord-018017-c8myq6bi 363 6 to to IN cord-018017-c8myq6bi 363 7 Lassa Lassa NNP cord-018017-c8myq6bi 363 8 Virus Virus NNP cord-018017-c8myq6bi 363 9 and and CC cord-018017-c8myq6bi 363 10 shares share NNS cord-018017-c8myq6bi 363 11 reservoir reservoir NN cord-018017-c8myq6bi 363 12 hosts host NNS cord-018017-c8myq6bi 363 13 . . . cord-018017-c8myq6bi 364 1 MV MV NNP cord-018017-c8myq6bi 364 2 is be VBZ cord-018017-c8myq6bi 364 3 naturally naturally RB cord-018017-c8myq6bi 364 4 attenuated attenuate VBN cord-018017-c8myq6bi 364 5 and and CC cord-018017-c8myq6bi 364 6 nonpathogenic nonpathogenic JJ cord-018017-c8myq6bi 364 7 in in IN cord-018017-c8myq6bi 364 8 humans human NNS cord-018017-c8myq6bi 364 9 . . . cord-018017-c8myq6bi 365 1 Infection infection NN cord-018017-c8myq6bi 365 2 of of IN cord-018017-c8myq6bi 365 3 humans human NNS cord-018017-c8myq6bi 365 4 with with IN cord-018017-c8myq6bi 365 5 MV MV NNP cord-018017-c8myq6bi 365 6 protects protect VBZ cord-018017-c8myq6bi 365 7 against against IN cord-018017-c8myq6bi 365 8 lethal lethal JJ cord-018017-c8myq6bi 365 9 challenge challenge NN cord-018017-c8myq6bi 365 10 with with IN cord-018017-c8myq6bi 365 11 LV LV NNP cord-018017-c8myq6bi 366 1 ( ( -LRB- cord-018017-c8myq6bi 366 2 Wulff Wulff NNP cord-018017-c8myq6bi 366 3 et et NNP cord-018017-c8myq6bi 366 4 al al NNP cord-018017-c8myq6bi 366 5 . . NNP cord-018017-c8myq6bi 366 6 1977 1977 CD cord-018017-c8myq6bi 366 7 ) ) -RRB- cord-018017-c8myq6bi 366 8 . . . cord-018017-c8myq6bi 367 1 Flaviviridae Flaviviridae NNP cord-018017-c8myq6bi 367 2 ) ) -RRB- cord-018017-c8myq6bi 367 3 named name VBN cord-018017-c8myq6bi 367 4 after after IN cord-018017-c8myq6bi 367 5 G. G. NNP cord-018017-c8myq6bi 367 6 Barker Barker NNP cord-018017-c8myq6bi 367 7 , , , cord-018017-c8myq6bi 367 8 a a DT cord-018017-c8myq6bi 367 9 surgeon surgeon NN cord-018017-c8myq6bi 367 10 , , , cord-018017-c8myq6bi 367 11 first first RB cord-018017-c8myq6bi 367 12 identified identify VBN cord-018017-c8myq6bi 367 13 in in IN cord-018017-c8myq6bi 367 14 1995 1995 CD cord-018017-c8myq6bi 367 15 . . . cord-018017-c8myq6bi 368 1 HGV HGV NNP cord-018017-c8myq6bi 368 2 infects infect VBZ cord-018017-c8myq6bi 368 3 one one CD cord-018017-c8myq6bi 368 4 sixth sixth NN cord-018017-c8myq6bi 368 5 of of IN cord-018017-c8myq6bi 368 6 the the DT cord-018017-c8myq6bi 368 7 world world NN cord-018017-c8myq6bi 368 8 's 's POS cord-018017-c8myq6bi 368 9 population population NN cord-018017-c8myq6bi 368 10 but but CC cord-018017-c8myq6bi 368 11 does do VBZ cord-018017-c8myq6bi 368 12 not not RB cord-018017-c8myq6bi 368 13 cause cause VB cord-018017-c8myq6bi 368 14 human human JJ cord-018017-c8myq6bi 368 15 disease disease NN cord-018017-c8myq6bi 368 16 . . . cord-018017-c8myq6bi 369 1 A a DT cord-018017-c8myq6bi 369 2 metaanalysis metaanalysis NN cord-018017-c8myq6bi 369 3 of of IN cord-018017-c8myq6bi 369 4 15 15 CD cord-018017-c8myq6bi 369 5 publications publication NNS cord-018017-c8myq6bi 369 6 investigating investigate VBG cord-018017-c8myq6bi 369 7 GBV GBV NNP cord-018017-c8myq6bi 369 8 - - HYPH cord-018017-c8myq6bi 369 9 C C NNP cord-018017-c8myq6bi 369 10 infections infection NNS cord-018017-c8myq6bi 369 11 in in IN cord-018017-c8myq6bi 369 12 HIV HIV NNP cord-018017-c8myq6bi 369 13 - - HYPH cord-018017-c8myq6bi 369 14 positive positive JJ cord-018017-c8myq6bi 369 15 individuals individual NNS cord-018017-c8myq6bi 369 16 indicate indicate VBP cord-018017-c8myq6bi 369 17 coinfection coinfection NN cord-018017-c8myq6bi 369 18 with with IN cord-018017-c8myq6bi 369 19 GBV GBV NNP cord-018017-c8myq6bi 369 20 - - HYPH cord-018017-c8myq6bi 369 21 C C NNP cord-018017-c8myq6bi 369 22 slows slow VBZ cord-018017-c8myq6bi 369 23 the the DT cord-018017-c8myq6bi 369 24 progression progression NN cord-018017-c8myq6bi 369 25 of of IN cord-018017-c8myq6bi 369 26 HIV HIV NNP cord-018017-c8myq6bi 369 27 disease disease NN cord-018017-c8myq6bi 369 28 in in IN cord-018017-c8myq6bi 369 29 individuals individual NNS cord-018017-c8myq6bi 369 30 that that WDT cord-018017-c8myq6bi 369 31 have have VBP cord-018017-c8myq6bi 369 32 been be VBN cord-018017-c8myq6bi 369 33 seropositive seropositive JJ cord-018017-c8myq6bi 369 34 for for IN cord-018017-c8myq6bi 369 35 2 2 CD cord-018017-c8myq6bi 369 36 years year NNS cord-018017-c8myq6bi 369 37 or or CC cord-018017-c8myq6bi 369 38 more more JJR cord-018017-c8myq6bi 369 39 ( ( -LRB- cord-018017-c8myq6bi 369 40 Zhang Zhang NNP cord-018017-c8myq6bi 369 41 et et NNP cord-018017-c8myq6bi 369 42 al al NNP cord-018017-c8myq6bi 369 43 . . NNP cord-018017-c8myq6bi 369 44 2006a 2006a CD cord-018017-c8myq6bi 369 45 ) ) -RRB- cord-018017-c8myq6bi 369 46 . . . cord-018017-c8myq6bi 370 1 Two two CD cord-018017-c8myq6bi 370 2 of of IN cord-018017-c8myq6bi 370 3 the the DT cord-018017-c8myq6bi 370 4 studies study NNS cord-018017-c8myq6bi 370 5 investigated investigate VBD cord-018017-c8myq6bi 370 6 GBV GBV NNP cord-018017-c8myq6bi 370 7 - - HYPH cord-018017-c8myq6bi 370 8 C C NNP cord-018017-c8myq6bi 370 9 5 5 CD cord-018017-c8myq6bi 370 10 years year NNS cord-018017-c8myq6bi 370 11 after after IN cord-018017-c8myq6bi 370 12 documented document VBN cord-018017-c8myq6bi 370 13 HIV HIV NNP cord-018017-c8myq6bi 370 14 seroconversion seroconversion NN cord-018017-c8myq6bi 370 15 estimate estimate VBP cord-018017-c8myq6bi 370 16 the the DT cord-018017-c8myq6bi 370 17 hazard hazard NN cord-018017-c8myq6bi 370 18 ratio ratio NN cord-018017-c8myq6bi 370 19 of of IN cord-018017-c8myq6bi 370 20 0.36 0.36 CD cord-018017-c8myq6bi 370 21 ( ( -LRB- cord-018017-c8myq6bi 370 22 95 95 CD cord-018017-c8myq6bi 370 23 % % NN cord-018017-c8myq6bi 370 24 CI CI NNP cord-018017-c8myq6bi 370 25 ) ) -RRB- cord-018017-c8myq6bi 370 26 . . . cord-018017-c8myq6bi 371 1 is be VBZ cord-018017-c8myq6bi 371 2 a a DT cord-018017-c8myq6bi 371 3 retrovirus retrovirus NN cord-018017-c8myq6bi 371 4 first first RB cord-018017-c8myq6bi 371 5 identified identify VBN cord-018017-c8myq6bi 371 6 in in IN cord-018017-c8myq6bi 371 7 1971 1971 CD cord-018017-c8myq6bi 371 8 from from IN cord-018017-c8myq6bi 371 9 a a DT cord-018017-c8myq6bi 371 10 lymphoblastoid lymphoblastoid NN cord-018017-c8myq6bi 371 11 cell cell NN cord-018017-c8myq6bi 371 12 culture culture NN cord-018017-c8myq6bi 371 13 from from IN cord-018017-c8myq6bi 371 14 a a DT cord-018017-c8myq6bi 371 15 Kenyan kenyan JJ cord-018017-c8myq6bi 371 16 patient patient NN cord-018017-c8myq6bi 371 17 with with IN cord-018017-c8myq6bi 371 18 nasopharyngeal nasopharyngeal JJ cord-018017-c8myq6bi 371 19 carcinoma carcinoma NN cord-018017-c8myq6bi 371 20 . . . cord-018017-c8myq6bi 372 1 HFV HFV NNP cord-018017-c8myq6bi 372 2 is be VBZ cord-018017-c8myq6bi 372 3 homologous homologous JJ cord-018017-c8myq6bi 372 4 to to IN cord-018017-c8myq6bi 372 5 primate primate JJ cord-018017-c8myq6bi 372 6 foamy foamy NN cord-018017-c8myq6bi 372 7 viruses virus NNS cord-018017-c8myq6bi 372 8 and and CC cord-018017-c8myq6bi 372 9 is be VBZ cord-018017-c8myq6bi 372 10 most most RBS cord-018017-c8myq6bi 372 11 closely closely RB cord-018017-c8myq6bi 372 12 related related JJ cord-018017-c8myq6bi 372 13 to to IN cord-018017-c8myq6bi 372 14 the the DT cord-018017-c8myq6bi 372 15 chimpanzee chimpanzee NN cord-018017-c8myq6bi 372 16 foamy foamy NN cord-018017-c8myq6bi 372 17 virus virus NN cord-018017-c8myq6bi 372 18 ( ( -LRB- cord-018017-c8myq6bi 372 19 SFVcpz SFVcpz NNP cord-018017-c8myq6bi 372 20 ) ) -RRB- cord-018017-c8myq6bi 372 21 . . . cord-018017-c8myq6bi 373 1 Early early JJ cord-018017-c8myq6bi 373 2 studies study NNS cord-018017-c8myq6bi 373 3 raised raise VBD cord-018017-c8myq6bi 373 4 alarm alarm NN cord-018017-c8myq6bi 373 5 for for IN cord-018017-c8myq6bi 373 6 association association NNP cord-018017-c8myq6bi 373 7 with with IN cord-018017-c8myq6bi 373 8 autoimmune autoimmune JJ cord-018017-c8myq6bi 373 9 diseases disease NNS cord-018017-c8myq6bi 373 10 but but CC cord-018017-c8myq6bi 373 11 more more RBR cord-018017-c8myq6bi 373 12 extensive extensive JJ cord-018017-c8myq6bi 373 13 studies study NNS cord-018017-c8myq6bi 373 14 with with IN cord-018017-c8myq6bi 373 15 more more RBR cord-018017-c8myq6bi 373 16 precise precise JJ cord-018017-c8myq6bi 373 17 diagnostic diagnostic JJ cord-018017-c8myq6bi 373 18 reagents reagent NNS cord-018017-c8myq6bi 373 19 fail fail VBP cord-018017-c8myq6bi 373 20 to to TO cord-018017-c8myq6bi 373 21 find find VB cord-018017-c8myq6bi 373 22 a a DT cord-018017-c8myq6bi 373 23 disease disease NN cord-018017-c8myq6bi 373 24 associated associate VBN cord-018017-c8myq6bi 373 25 with with IN cord-018017-c8myq6bi 373 26 HFV HFV NNP cord-018017-c8myq6bi 373 27 . . . cord-018017-c8myq6bi 374 1 HFV HFV NNP cord-018017-c8myq6bi 374 2 is be VBZ cord-018017-c8myq6bi 374 3 a a DT cord-018017-c8myq6bi 374 4 rare rare JJ cord-018017-c8myq6bi 374 5 human human JJ cord-018017-c8myq6bi 374 6 infection infection NN cord-018017-c8myq6bi 374 7 and and CC cord-018017-c8myq6bi 374 8 concerns concern NNS cord-018017-c8myq6bi 374 9 parallel parallel JJ cord-018017-c8myq6bi 374 10 SFV sfv NN cord-018017-c8myq6bi 374 11 infections infection NNS cord-018017-c8myq6bi 374 12 in in IN cord-018017-c8myq6bi 374 13 humans human NNS cord-018017-c8myq6bi 374 14 . . . cord-018017-c8myq6bi 375 1 Simian simian JJ cord-018017-c8myq6bi 375 2 Foamy Foamy NNP cord-018017-c8myq6bi 375 3 Virus virus NN cord-018017-c8myq6bi 375 4 ( ( -LRB- cord-018017-c8myq6bi 375 5 SFV SFV NNP cord-018017-c8myq6bi 375 6 ; ; : cord-018017-c8myq6bi 375 7 Spumavirus Spumavirus NNP cord-018017-c8myq6bi 375 8 - - HYPH cord-018017-c8myq6bi 375 9 retroviridae retroviridae NNP cord-018017-c8myq6bi 375 10 ) ) -RRB- cord-018017-c8myq6bi 375 11 is be VBZ cord-018017-c8myq6bi 375 12 a a DT cord-018017-c8myq6bi 375 13 retrovirus retrovirus NN cord-018017-c8myq6bi 375 14 infecting infect VBG cord-018017-c8myq6bi 375 15 most most JJS cord-018017-c8myq6bi 375 16 primates primate NNS cord-018017-c8myq6bi 375 17 born bear VBN cord-018017-c8myq6bi 375 18 in in IN cord-018017-c8myq6bi 375 19 captivity captivity NN cord-018017-c8myq6bi 375 20 and and CC cord-018017-c8myq6bi 375 21 people people NNS cord-018017-c8myq6bi 375 22 making make VBG cord-018017-c8myq6bi 375 23 contact contact NN cord-018017-c8myq6bi 375 24 with with IN cord-018017-c8myq6bi 375 25 infected infected JJ cord-018017-c8myq6bi 375 26 primates primate NNS cord-018017-c8myq6bi 375 27 can can MD cord-018017-c8myq6bi 375 28 become become VB cord-018017-c8myq6bi 375 29 infected infected JJ cord-018017-c8myq6bi 375 30 . . . cord-018017-c8myq6bi 376 1 Human human JJ cord-018017-c8myq6bi 376 2 infections infection NNS cord-018017-c8myq6bi 376 3 frequently frequently RB cord-018017-c8myq6bi 376 4 occur occur VBP cord-018017-c8myq6bi 376 5 in in IN cord-018017-c8myq6bi 376 6 males male NNS cord-018017-c8myq6bi 376 7 probably probably RB cord-018017-c8myq6bi 376 8 requiring require VBG cord-018017-c8myq6bi 376 9 a a DT cord-018017-c8myq6bi 376 10 bite bite NN cord-018017-c8myq6bi 376 11 from from IN cord-018017-c8myq6bi 376 12 infected infected JJ cord-018017-c8myq6bi 376 13 nonhuman nonhuman NN cord-018017-c8myq6bi 376 14 primates primate NNS cord-018017-c8myq6bi 376 15 but but CC cord-018017-c8myq6bi 376 16 are be VBP cord-018017-c8myq6bi 376 17 harmless harmless JJ cord-018017-c8myq6bi 376 18 . . . cord-018017-c8myq6bi 377 1 The the DT cord-018017-c8myq6bi 377 2 infected infected JJ cord-018017-c8myq6bi 377 3 cells cell NNS cord-018017-c8myq6bi 377 4 often often RB cord-018017-c8myq6bi 377 5 fuse fuse VBP cord-018017-c8myq6bi 377 6 to to TO cord-018017-c8myq6bi 377 7 form form VB cord-018017-c8myq6bi 377 8 syncytia syncytia NN cord-018017-c8myq6bi 377 9 of of IN cord-018017-c8myq6bi 377 10 giant giant JJ cord-018017-c8myq6bi 377 11 foamy foamy NN cord-018017-c8myq6bi 377 12 cells cell NNS cord-018017-c8myq6bi 377 13 , , , cord-018017-c8myq6bi 377 14 which which WDT cord-018017-c8myq6bi 377 15 gives give VBZ cord-018017-c8myq6bi 377 16 the the DT cord-018017-c8myq6bi 377 17 virus virus NN cord-018017-c8myq6bi 377 18 its -PRON- PRP$ cord-018017-c8myq6bi 377 19 name name NN cord-018017-c8myq6bi 377 20 . . . cord-018017-c8myq6bi 378 1 The the DT cord-018017-c8myq6bi 378 2 error error NN cord-018017-c8myq6bi 378 3 rate rate NN cord-018017-c8myq6bi 378 4 in in IN cord-018017-c8myq6bi 378 5 SFV sfv NN cord-018017-c8myq6bi 378 6 genomes genome NNS cord-018017-c8myq6bi 378 7 is be VBZ cord-018017-c8myq6bi 378 8 exceptionally exceptionally RB cord-018017-c8myq6bi 378 9 low low JJ cord-018017-c8myq6bi 378 10 , , , cord-018017-c8myq6bi 378 11 1.7 1.7 CD cord-018017-c8myq6bi 378 12 x x SYM cord-018017-c8myq6bi 378 13 10 10 CD cord-018017-c8myq6bi 378 14 −8 −8 NNP cord-018017-c8myq6bi 378 15 substitutions substitution NNS cord-018017-c8myq6bi 378 16 per per IN cord-018017-c8myq6bi 378 17 site site NN cord-018017-c8myq6bi 378 18 per per IN cord-018017-c8myq6bi 378 19 year year NN cord-018017-c8myq6bi 378 20 , , , cord-018017-c8myq6bi 378 21 compared compare VBN cord-018017-c8myq6bi 378 22 to to IN cord-018017-c8myq6bi 378 23 HIV HIV NNP cord-018017-c8myq6bi 378 24 10 10 CD cord-018017-c8myq6bi 378 25 −3 −3 NNP cord-018017-c8myq6bi 378 26 substitutions substitution NNS cord-018017-c8myq6bi 378 27 per per IN cord-018017-c8myq6bi 378 28 site site NN cord-018017-c8myq6bi 378 29 per per IN cord-018017-c8myq6bi 378 30 year year NN cord-018017-c8myq6bi 378 31 . . . cord-018017-c8myq6bi 379 1 Since since IN cord-018017-c8myq6bi 379 2 so so RB cord-018017-c8myq6bi 379 3 - - HYPH cord-018017-c8myq6bi 379 4 called call VBN cord-018017-c8myq6bi 379 5 crossspecies crossspecie NNS cord-018017-c8myq6bi 379 6 , , , cord-018017-c8myq6bi 379 7 infections infection NNS cord-018017-c8myq6bi 379 8 have have VBP cord-018017-c8myq6bi 379 9 only only RB cord-018017-c8myq6bi 379 10 been be VBN cord-018017-c8myq6bi 379 11 observed observe VBN cord-018017-c8myq6bi 379 12 for for IN cord-018017-c8myq6bi 379 13 a a DT cord-018017-c8myq6bi 379 14 little little JJ cord-018017-c8myq6bi 379 15 over over IN cord-018017-c8myq6bi 379 16 a a DT cord-018017-c8myq6bi 379 17 decade decade NN cord-018017-c8myq6bi 379 18 the the DT cord-018017-c8myq6bi 379 19 long long JJ cord-018017-c8myq6bi 379 20 term term NN cord-018017-c8myq6bi 379 21 consequences consequence NNS cord-018017-c8myq6bi 379 22 are be VBP cord-018017-c8myq6bi 379 23 not not RB cord-018017-c8myq6bi 379 24 known know VBN cord-018017-c8myq6bi 379 25 . . . cord-018017-c8myq6bi 380 1 These these DT cord-018017-c8myq6bi 380 2 infections infection NNS cord-018017-c8myq6bi 380 3 are be VBP cord-018017-c8myq6bi 380 4 watch watch VB cord-018017-c8myq6bi 380 5 and and CC cord-018017-c8myq6bi 380 6 wait wait VB cord-018017-c8myq6bi 380 7 for for IN cord-018017-c8myq6bi 380 8 everything everything NN cord-018017-c8myq6bi 380 9 from from IN cord-018017-c8myq6bi 380 10 a a DT cord-018017-c8myq6bi 380 11 zoonotic zoonotic JJ cord-018017-c8myq6bi 380 12 epidemic epidemic NN cord-018017-c8myq6bi 380 13 to to IN cord-018017-c8myq6bi 380 14 identified identify VBN cord-018017-c8myq6bi 380 15 disease disease NN cord-018017-c8myq6bi 380 16 clusters cluster NNS cord-018017-c8myq6bi 380 17 . . . cord-018017-c8myq6bi 381 1 Perhaps perhaps RB cord-018017-c8myq6bi 381 2 this this DT cord-018017-c8myq6bi 381 3 is be VBZ cord-018017-c8myq6bi 381 4 exactly exactly RB cord-018017-c8myq6bi 381 5 the the DT cord-018017-c8myq6bi 381 6 sort sort NN cord-018017-c8myq6bi 381 7 of of IN cord-018017-c8myq6bi 381 8 infection infection NN cord-018017-c8myq6bi 381 9 that that WDT cord-018017-c8myq6bi 381 10 will will MD cord-018017-c8myq6bi 381 11 emerge emerge VB cord-018017-c8myq6bi 381 12 as as IN cord-018017-c8myq6bi 381 13 a a DT cord-018017-c8myq6bi 381 14 significant significant JJ cord-018017-c8myq6bi 381 15 human human JJ cord-018017-c8myq6bi 381 16 concern concern NN cord-018017-c8myq6bi 381 17 in in IN cord-018017-c8myq6bi 381 18 the the DT cord-018017-c8myq6bi 381 19 future future NN cord-018017-c8myq6bi 381 20 . . . cord-018017-c8myq6bi 382 1 Torque Torque NNP cord-018017-c8myq6bi 382 2 Teno Teno NNP cord-018017-c8myq6bi 382 3 Virus virus NN cord-018017-c8myq6bi 382 4 ( ( -LRB- cord-018017-c8myq6bi 382 5 TTV TTV NNP cord-018017-c8myq6bi 382 6 ; ; : cord-018017-c8myq6bi 382 7 Alphatorquevirus Alphatorquevirus NNP cord-018017-c8myq6bi 382 8 ) ) -RRB- cord-018017-c8myq6bi 382 9 is be VBZ cord-018017-c8myq6bi 382 10 a a DT cord-018017-c8myq6bi 382 11 single single JJ cord-018017-c8myq6bi 382 12 - - HYPH cord-018017-c8myq6bi 382 13 stranded stranded JJ cord-018017-c8myq6bi 382 14 , , , cord-018017-c8myq6bi 382 15 positive positive JJ cord-018017-c8myq6bi 382 16 sense sense NN cord-018017-c8myq6bi 382 17 DNA dna NN cord-018017-c8myq6bi 382 18 genome genome NN cord-018017-c8myq6bi 382 19 virus virus NN cord-018017-c8myq6bi 382 20 about about IN cord-018017-c8myq6bi 382 21 3.8 3.8 CD cord-018017-c8myq6bi 382 22 kb kb NNS cord-018017-c8myq6bi 382 23 in in IN cord-018017-c8myq6bi 382 24 size size NN cord-018017-c8myq6bi 382 25 in in IN cord-018017-c8myq6bi 382 26 the the DT cord-018017-c8myq6bi 382 27 Anelloviridae Anelloviridae NNP cord-018017-c8myq6bi 382 28 family family NN cord-018017-c8myq6bi 382 29 . . . cord-018017-c8myq6bi 383 1 Nearly nearly RB cord-018017-c8myq6bi 383 2 100 100 CD cord-018017-c8myq6bi 383 3 percent percent NN cord-018017-c8myq6bi 383 4 of of IN cord-018017-c8myq6bi 383 5 even even RB cord-018017-c8myq6bi 383 6 healthy healthy JJ cord-018017-c8myq6bi 383 7 individuals individual NNS cord-018017-c8myq6bi 383 8 are be VBP cord-018017-c8myq6bi 383 9 infected infect VBN cord-018017-c8myq6bi 383 10 in in IN cord-018017-c8myq6bi 383 11 some some DT cord-018017-c8myq6bi 383 12 countries country NNS cord-018017-c8myq6bi 383 13 . . . cord-018017-c8myq6bi 384 1 The the DT cord-018017-c8myq6bi 384 2 virus virus NN cord-018017-c8myq6bi 384 3 was be VBD cord-018017-c8myq6bi 384 4 discovered discover VBN cord-018017-c8myq6bi 384 5 in in IN cord-018017-c8myq6bi 384 6 1997 1997 CD cord-018017-c8myq6bi 384 7 as as IN cord-018017-c8myq6bi 384 8 the the DT cord-018017-c8myq6bi 384 9 " " `` cord-018017-c8myq6bi 384 10 transfusion transfusion NN cord-018017-c8myq6bi 384 11 transmitted transmit VBN cord-018017-c8myq6bi 384 12 virus virus NN cord-018017-c8myq6bi 384 13 ( ( -LRB- cord-018017-c8myq6bi 384 14 TTV TTV NNP cord-018017-c8myq6bi 384 15 ) ) -RRB- cord-018017-c8myq6bi 384 16 " " `` cord-018017-c8myq6bi 384 17 in in IN cord-018017-c8myq6bi 384 18 a a DT cord-018017-c8myq6bi 384 19 Japanese japanese JJ cord-018017-c8myq6bi 384 20 patient patient NN cord-018017-c8myq6bi 384 21 . . . cord-018017-c8myq6bi 385 1 It -PRON- PRP cord-018017-c8myq6bi 385 2 is be VBZ cord-018017-c8myq6bi 385 3 often often RB cord-018017-c8myq6bi 385 4 found find VBN cord-018017-c8myq6bi 385 5 in in IN cord-018017-c8myq6bi 385 6 patients patient NNS cord-018017-c8myq6bi 385 7 with with IN cord-018017-c8myq6bi 385 8 liver liver NN cord-018017-c8myq6bi 385 9 disease disease NN cord-018017-c8myq6bi 385 10 but but CC cord-018017-c8myq6bi 385 11 does do VBZ cord-018017-c8myq6bi 385 12 not not RB cord-018017-c8myq6bi 385 13 cause cause VB cord-018017-c8myq6bi 385 14 hepatitis hepatitis NN cord-018017-c8myq6bi 385 15 on on IN cord-018017-c8myq6bi 385 16 its -PRON- PRP$ cord-018017-c8myq6bi 385 17 own own JJ cord-018017-c8myq6bi 385 18 . . . cord-018017-c8myq6bi 386 1 Closely closely RB cord-018017-c8myq6bi 386 2 related relate VBN cord-018017-c8myq6bi 386 3 Torque Torque NNP cord-018017-c8myq6bi 386 4 Teno Teno NNP cord-018017-c8myq6bi 386 5 mini mini NN cord-018017-c8myq6bi 386 6 virus virus NN cord-018017-c8myq6bi 386 7 ( ( -LRB- cord-018017-c8myq6bi 386 8 TTMV TTMV NNP cord-018017-c8myq6bi 386 9 ) ) -RRB- cord-018017-c8myq6bi 386 10 were be VBD cord-018017-c8myq6bi 386 11 isolated isolate VBN cord-018017-c8myq6bi 386 12 in in IN cord-018017-c8myq6bi 386 13 2007 2007 CD cord-018017-c8myq6bi 386 14 and and CC cord-018017-c8myq6bi 386 15 found find VBD cord-018017-c8myq6bi 386 16 to to TO cord-018017-c8myq6bi 386 17 have have VB cord-018017-c8myq6bi 386 18 smaller small JJR cord-018017-c8myq6bi 386 19 genomes genome NNS cord-018017-c8myq6bi 386 20 of of IN cord-018017-c8myq6bi 386 21 2.8 2.8 CD cord-018017-c8myq6bi 386 22 - - SYM cord-018017-c8myq6bi 386 23 2.9 2.9 CD cord-018017-c8myq6bi 386 24 kb kb NNS cord-018017-c8myq6bi 386 25 . . . cord-018017-c8myq6bi 387 1 TTMV TTMV NNP cord-018017-c8myq6bi 387 2 infections infection NNS cord-018017-c8myq6bi 387 3 are be VBP cord-018017-c8myq6bi 387 4 also also RB cord-018017-c8myq6bi 387 5 common common JJ cord-018017-c8myq6bi 387 6 but but CC cord-018017-c8myq6bi 387 7 do do VBP cord-018017-c8myq6bi 387 8 not not RB cord-018017-c8myq6bi 387 9 cause cause VB cord-018017-c8myq6bi 387 10 any any DT cord-018017-c8myq6bi 387 11 described describe VBN cord-018017-c8myq6bi 387 12 human human JJ cord-018017-c8myq6bi 387 13 disease disease NN cord-018017-c8myq6bi 387 14 . . . cord-018017-c8myq6bi 388 1 Human Human NNP cord-018017-c8myq6bi 388 2 Adenovirus Adenovirus NNP cord-018017-c8myq6bi 388 3 Type Type NNP cord-018017-c8myq6bi 388 4 5 5 CD cord-018017-c8myq6bi 388 5 ( ( -LRB- cord-018017-c8myq6bi 388 6 rAd5 rAd5 '' cord-018017-c8myq6bi 388 7 ) ) -RRB- cord-018017-c8myq6bi 388 8 is be VBZ cord-018017-c8myq6bi 388 9 used use VBN cord-018017-c8myq6bi 388 10 to to TO cord-018017-c8myq6bi 388 11 create create VB cord-018017-c8myq6bi 388 12 an an DT cord-018017-c8myq6bi 388 13 Ebolavirus ebolavirus NN cord-018017-c8myq6bi 388 14 ( ( -LRB- cord-018017-c8myq6bi 388 15 EBOV EBOV NNP cord-018017-c8myq6bi 388 16 ) ) -RRB- cord-018017-c8myq6bi 388 17 vaccine vaccine NN cord-018017-c8myq6bi 388 18 encoding encode VBG cord-018017-c8myq6bi 388 19 Zaire Zaire NNP cord-018017-c8myq6bi 388 20 ebolavirus ebolavirus NN cord-018017-c8myq6bi 388 21 glycoprotein glycoprotein NN cord-018017-c8myq6bi 388 22 failed fail VBD cord-018017-c8myq6bi 388 23 to to TO cord-018017-c8myq6bi 388 24 protect protect VB cord-018017-c8myq6bi 388 25 animals animal NNS cord-018017-c8myq6bi 388 26 immune immune JJ cord-018017-c8myq6bi 388 27 to to IN cord-018017-c8myq6bi 388 28 Ad5 ad5 CD cord-018017-c8myq6bi 388 29 . . . cord-018017-c8myq6bi 389 1 A a DT cord-018017-c8myq6bi 389 2 replication replication NN cord-018017-c8myq6bi 389 3 defective defective JJ cord-018017-c8myq6bi 389 4 chimpanzee chimpanzee NN cord-018017-c8myq6bi 389 5 - - HYPH cord-018017-c8myq6bi 389 6 derived derive VBN cord-018017-c8myq6bi 389 7 adenovirus adenovirus NN cord-018017-c8myq6bi 389 8 ( ( -LRB- cord-018017-c8myq6bi 389 9 ChAd3-EBO ChAd3-EBO NNP cord-018017-c8myq6bi 389 10 - - HYPH cord-018017-c8myq6bi 389 11 Z Z NNP cord-018017-c8myq6bi 389 12 ) ) -RRB- cord-018017-c8myq6bi 389 13 provided provide VBD cord-018017-c8myq6bi 389 14 protection protection NN cord-018017-c8myq6bi 389 15 against against IN cord-018017-c8myq6bi 389 16 lethal lethal JJ cord-018017-c8myq6bi 389 17 EBOV EBOV NNP cord-018017-c8myq6bi 389 18 challenge challenge NN cord-018017-c8myq6bi 389 19 in in IN cord-018017-c8myq6bi 389 20 macaques macaque NNS cord-018017-c8myq6bi 389 21 but but CC cord-018017-c8myq6bi 389 22 protection protection NN cord-018017-c8myq6bi 389 23 wane wane VBP cord-018017-c8myq6bi 389 24 over over IN cord-018017-c8myq6bi 389 25 several several JJ cord-018017-c8myq6bi 389 26 months month NNS cord-018017-c8myq6bi 389 27 . . . cord-018017-c8myq6bi 390 1 They -PRON- PRP cord-018017-c8myq6bi 390 2 boosted boost VBD cord-018017-c8myq6bi 390 3 with with IN cord-018017-c8myq6bi 390 4 a a DT cord-018017-c8myq6bi 390 5 modified modify VBN cord-018017-c8myq6bi 390 6 vaccinia vaccinia NN cord-018017-c8myq6bi 390 7 Ankara Ankara NNP cord-018017-c8myq6bi 390 8 ( ( -LRB- cord-018017-c8myq6bi 390 9 MVA MVA NNP cord-018017-c8myq6bi 390 10 - - HYPH cord-018017-c8myq6bi 390 11 BN BN NNP cord-018017-c8myq6bi 390 12 - - HYPH cord-018017-c8myq6bi 390 13 Filo Filo NNP cord-018017-c8myq6bi 390 14 ) ) -RRB- cord-018017-c8myq6bi 390 15 that that WDT cord-018017-c8myq6bi 390 16 led lead VBD cord-018017-c8myq6bi 390 17 to to IN cord-018017-c8myq6bi 390 18 durable durable JJ cord-018017-c8myq6bi 390 19 protection protection NN cord-018017-c8myq6bi 390 20 ( ( -LRB- cord-018017-c8myq6bi 390 21 Stanley Stanley NNP cord-018017-c8myq6bi 390 22 et et NNP cord-018017-c8myq6bi 390 23 al al NNP cord-018017-c8myq6bi 390 24 . . NNP cord-018017-c8myq6bi 390 25 2014 2014 CD cord-018017-c8myq6bi 390 26 ) ) -RRB- cord-018017-c8myq6bi 390 27 . . . cord-018017-c8myq6bi 391 1 This this DT cord-018017-c8myq6bi 391 2 vaccine vaccine NN cord-018017-c8myq6bi 391 3 progressed progress VBD cord-018017-c8myq6bi 391 4 through through IN cord-018017-c8myq6bi 391 5 phase phase NN cord-018017-c8myq6bi 391 6 I -PRON- PRP cord-018017-c8myq6bi 391 7 , , , cord-018017-c8myq6bi 391 8 single single JJ cord-018017-c8myq6bi 391 9 - - HYPH cord-018017-c8myq6bi 391 10 blind blind JJ cord-018017-c8myq6bi 391 11 , , , cord-018017-c8myq6bi 391 12 randomized randomized JJ cord-018017-c8myq6bi 391 13 human human JJ cord-018017-c8myq6bi 391 14 trials trial NNS cord-018017-c8myq6bi 391 15 in in IN cord-018017-c8myq6bi 391 16 Mali Mali NNP cord-018017-c8myq6bi 391 17 between between IN cord-018017-c8myq6bi 391 18 2014 2014 CD cord-018017-c8myq6bi 391 19 and and CC cord-018017-c8myq6bi 391 20 2015 2015 CD cord-018017-c8myq6bi 391 21 . . . cord-018017-c8myq6bi 392 1 A a DT cord-018017-c8myq6bi 392 2 single single JJ cord-018017-c8myq6bi 392 3 dose dose NN cord-018017-c8myq6bi 392 4 of of IN cord-018017-c8myq6bi 392 5 the the DT cord-018017-c8myq6bi 392 6 ChAd3-EVOV ChAd3-EVOV NNP cord-018017-c8myq6bi 392 7 - - HYPH cord-018017-c8myq6bi 392 8 Z Z NNP cord-018017-c8myq6bi 392 9 is be VBZ cord-018017-c8myq6bi 392 10 efficient efficient JJ cord-018017-c8myq6bi 392 11 as as IN cord-018017-c8myq6bi 392 12 a a DT cord-018017-c8myq6bi 392 13 prime prime JJ cord-018017-c8myq6bi 392 14 vaccine vaccine NN cord-018017-c8myq6bi 392 15 strategy strategy NN cord-018017-c8myq6bi 392 16 followed follow VBN cord-018017-c8myq6bi 392 17 by by IN cord-018017-c8myq6bi 392 18 MVA MVA NNP cord-018017-c8myq6bi 392 19 - - HYPH cord-018017-c8myq6bi 392 20 BN BN NNP cord-018017-c8myq6bi 392 21 - - HYPH cord-018017-c8myq6bi 392 22 Filo Filo NNP cord-018017-c8myq6bi 392 23 as as IN cord-018017-c8myq6bi 392 24 a a DT cord-018017-c8myq6bi 392 25 boost boost NN cord-018017-c8myq6bi 392 26 was be VBD cord-018017-c8myq6bi 392 27 well well RB cord-018017-c8myq6bi 392 28 tolerated tolerate VBN cord-018017-c8myq6bi 392 29 in in IN cord-018017-c8myq6bi 392 30 humans human NNS cord-018017-c8myq6bi 392 31 Tapia Tapia NNP cord-018017-c8myq6bi 392 32 et et NNP cord-018017-c8myq6bi 392 33 al al NNP cord-018017-c8myq6bi 392 34 . . . cord-018017-c8myq6bi 392 35 2016 2016 CD cord-018017-c8myq6bi 392 36 ) ) -RRB- cord-018017-c8myq6bi 392 37 . . . cord-018017-c8myq6bi 393 1 is be VBZ cord-018017-c8myq6bi 393 2 a a DT cord-018017-c8myq6bi 393 3 5229 5229 CD cord-018017-c8myq6bi 393 4 base base NN cord-018017-c8myq6bi 393 5 double double RB cord-018017-c8myq6bi 393 6 - - HYPH cord-018017-c8myq6bi 393 7 stranded strand VBN cord-018017-c8myq6bi 393 8 DNA dna NN cord-018017-c8myq6bi 393 9 virus virus NN cord-018017-c8myq6bi 393 10 infecting infect VBG cord-018017-c8myq6bi 393 11 less less JJR cord-018017-c8myq6bi 393 12 than than IN cord-018017-c8myq6bi 393 13 5 5 CD cord-018017-c8myq6bi 393 14 percent percent NN cord-018017-c8myq6bi 393 15 of of IN cord-018017-c8myq6bi 393 16 the the DT cord-018017-c8myq6bi 393 17 human human JJ cord-018017-c8myq6bi 393 18 population population NN cord-018017-c8myq6bi 393 19 . . . cord-018017-c8myq6bi 394 1 Wu Wu NNP cord-018017-c8myq6bi 394 2 , , , cord-018017-c8myq6bi 394 3 named name VBN cord-018017-c8myq6bi 394 4 after after IN cord-018017-c8myq6bi 394 5 Washington Washington NNP cord-018017-c8myq6bi 394 6 University University NNP cord-018017-c8myq6bi 394 7 , , , cord-018017-c8myq6bi 394 8 is be VBZ cord-018017-c8myq6bi 394 9 found find VBN cord-018017-c8myq6bi 394 10 as as IN cord-018017-c8myq6bi 394 11 a a DT cord-018017-c8myq6bi 394 12 co co NN cord-018017-c8myq6bi 394 13 - - NN cord-018017-c8myq6bi 394 14 infection infection NN cord-018017-c8myq6bi 394 15 in in IN cord-018017-c8myq6bi 394 16 various various JJ cord-018017-c8myq6bi 394 17 respiratory respiratory JJ cord-018017-c8myq6bi 394 18 infections infection NNS cord-018017-c8myq6bi 394 19 but but CC cord-018017-c8myq6bi 394 20 WU WU NNP cord-018017-c8myq6bi 394 21 does do VBZ cord-018017-c8myq6bi 394 22 not not RB cord-018017-c8myq6bi 394 23 cause cause VB cord-018017-c8myq6bi 394 24 disease disease NN cord-018017-c8myq6bi 394 25 on on IN cord-018017-c8myq6bi 394 26 its -PRON- PRP$ cord-018017-c8myq6bi 394 27 own own JJ cord-018017-c8myq6bi 394 28 . . . cord-018017-c8myq6bi 395 1 WU WU NNP cord-018017-c8myq6bi 395 2 is be VBZ cord-018017-c8myq6bi 395 3 closely closely RB cord-018017-c8myq6bi 395 4 related relate VBN cord-018017-c8myq6bi 395 5 to to IN cord-018017-c8myq6bi 395 6 KI KI NNP cord-018017-c8myq6bi 395 7 virus virus NN cord-018017-c8myq6bi 395 8 that that WDT cord-018017-c8myq6bi 395 9 also also RB cord-018017-c8myq6bi 395 10 is be VBZ cord-018017-c8myq6bi 395 11 not not RB cord-018017-c8myq6bi 395 12 known know VBN cord-018017-c8myq6bi 395 13 to to TO cord-018017-c8myq6bi 395 14 cause cause VB cord-018017-c8myq6bi 395 15 clinical clinical JJ cord-018017-c8myq6bi 395 16 disease disease NN cord-018017-c8myq6bi 395 17 . . . cord-018017-c8myq6bi 396 1 However however RB cord-018017-c8myq6bi 396 2 , , , cord-018017-c8myq6bi 396 3 related related JJ cord-018017-c8myq6bi 396 4 polyomaviruses polyomaviruse NNS cord-018017-c8myq6bi 396 5 that that WDT cord-018017-c8myq6bi 396 6 are be VBP cord-018017-c8myq6bi 396 7 clinically clinically RB cord-018017-c8myq6bi 396 8 relevant relevant JJ cord-018017-c8myq6bi 396 9 include include VBP cord-018017-c8myq6bi 396 10 BK BK NNP cord-018017-c8myq6bi 396 11 virus virus NN cord-018017-c8myq6bi 396 12 associated associate VBN cord-018017-c8myq6bi 396 13 with with IN cord-018017-c8myq6bi 396 14 nephropathy nephropathy NN cord-018017-c8myq6bi 396 15 , , , cord-018017-c8myq6bi 396 16 JC JC NNP cord-018017-c8myq6bi 396 17 virus virus NN cord-018017-c8myq6bi 396 18 associated associate VBN cord-018017-c8myq6bi 396 19 with with IN cord-018017-c8myq6bi 396 20 progressive progressive JJ cord-018017-c8myq6bi 396 21 multifocal multifocal JJ cord-018017-c8myq6bi 396 22 leukoencephalopathy leukoencephalopathy NNS cord-018017-c8myq6bi 396 23 , , , cord-018017-c8myq6bi 396 24 SV40 SV40 NNP cord-018017-c8myq6bi 396 25 virus virus NN cord-018017-c8myq6bi 396 26 associated associate VBN cord-018017-c8myq6bi 396 27 with with IN cord-018017-c8myq6bi 396 28 mesothelioma mesothelioma NN cord-018017-c8myq6bi 396 29 , , , cord-018017-c8myq6bi 396 30 and and CC cord-018017-c8myq6bi 396 31 Merkel Merkel NNP cord-018017-c8myq6bi 396 32 cell cell NN cord-018017-c8myq6bi 396 33 polyomavirus polyomavirus NN cord-018017-c8myq6bi 396 34 associated associate VBN cord-018017-c8myq6bi 396 35 with with IN cord-018017-c8myq6bi 396 36 cancer cancer NN cord-018017-c8myq6bi 396 37 . . . cord-018017-c8myq6bi 397 1 Vaccinia vaccinia NN cord-018017-c8myq6bi 397 2 virus virus NN cord-018017-c8myq6bi 397 3 ( ( -LRB- cord-018017-c8myq6bi 397 4 Orthopoxvirus Orthopoxvirus NNP cord-018017-c8myq6bi 397 5 ) ) -RRB- cord-018017-c8myq6bi 397 6 is be VBZ cord-018017-c8myq6bi 397 7 a a DT cord-018017-c8myq6bi 397 8 large large JJ cord-018017-c8myq6bi 397 9 double double JJ cord-018017-c8myq6bi 397 10 stranded strand VBN cord-018017-c8myq6bi 397 11 DNA dna NN cord-018017-c8myq6bi 397 12 virus virus NN cord-018017-c8myq6bi 397 13 closely closely RB cord-018017-c8myq6bi 397 14 related relate VBN cord-018017-c8myq6bi 397 15 to to IN cord-018017-c8myq6bi 397 16 Smallpox Smallpox NNP cord-018017-c8myq6bi 397 17 . . . cord-018017-c8myq6bi 398 1 Edward Edward NNP cord-018017-c8myq6bi 398 2 Jenner Jenner NNP cord-018017-c8myq6bi 398 3 , , , cord-018017-c8myq6bi 398 4 the the DT cord-018017-c8myq6bi 398 5 father father NNP cord-018017-c8myq6bi 398 6 of of IN cord-018017-c8myq6bi 398 7 immunology immunology NNP cord-018017-c8myq6bi 398 8 , , , cord-018017-c8myq6bi 398 9 found find VBD cord-018017-c8myq6bi 398 10 the the DT cord-018017-c8myq6bi 398 11 milkmaids milkmaid NNS cord-018017-c8myq6bi 398 12 exposed expose VBN cord-018017-c8myq6bi 398 13 to to IN cord-018017-c8myq6bi 398 14 cowpox cowpox NN cord-018017-c8myq6bi 398 15 ( ( -LRB- cord-018017-c8myq6bi 398 16 vaccinia vaccinia NN cord-018017-c8myq6bi 398 17 ) ) -RRB- cord-018017-c8myq6bi 398 18 were be VBD cord-018017-c8myq6bi 398 19 immune immune JJ cord-018017-c8myq6bi 398 20 to to IN cord-018017-c8myq6bi 398 21 smallpox smallpox NN cord-018017-c8myq6bi 398 22 in in IN cord-018017-c8myq6bi 398 23 1798 1798 CD cord-018017-c8myq6bi 398 24 . . . cord-018017-c8myq6bi 399 1 This this DT cord-018017-c8myq6bi 399 2 was be VBD cord-018017-c8myq6bi 399 3 the the DT cord-018017-c8myq6bi 399 4 first first JJ cord-018017-c8myq6bi 399 5 vaccine vaccine NN cord-018017-c8myq6bi 399 6 ( ( -LRB- cord-018017-c8myq6bi 399 7 named name VBN cord-018017-c8myq6bi 399 8 after after IN cord-018017-c8myq6bi 399 9 vaccinia vaccinia NN cord-018017-c8myq6bi 399 10 ) ) -RRB- cord-018017-c8myq6bi 399 11 leading lead VBG cord-018017-c8myq6bi 399 12 to to IN cord-018017-c8myq6bi 399 13 the the DT cord-018017-c8myq6bi 399 14 modern modern JJ cord-018017-c8myq6bi 399 15 vaccine vaccine NN cord-018017-c8myq6bi 399 16 that that WDT cord-018017-c8myq6bi 399 17 has have VBZ cord-018017-c8myq6bi 399 18 allowed allow VBN cord-018017-c8myq6bi 399 19 for for IN cord-018017-c8myq6bi 399 20 the the DT cord-018017-c8myq6bi 399 21 eradication eradication NN cord-018017-c8myq6bi 399 22 of of IN cord-018017-c8myq6bi 399 23 smallpox smallpox NN cord-018017-c8myq6bi 399 24 . . . cord-018017-c8myq6bi 400 1 Viral viral JJ cord-018017-c8myq6bi 400 2 sequences sequence NNS cord-018017-c8myq6bi 400 3 are be VBP cord-018017-c8myq6bi 400 4 constantly constantly RB cord-018017-c8myq6bi 400 5 mutating mutate VBG cord-018017-c8myq6bi 400 6 with with IN cord-018017-c8myq6bi 400 7 no no DT cord-018017-c8myq6bi 400 8 purpose purpose NN cord-018017-c8myq6bi 400 9 other other JJ cord-018017-c8myq6bi 400 10 than than IN cord-018017-c8myq6bi 400 11 seeking seek VBG cord-018017-c8myq6bi 400 12 a a DT cord-018017-c8myq6bi 400 13 survival survival NN cord-018017-c8myq6bi 400 14 / / SYM cord-018017-c8myq6bi 400 15 infectivity infectivity NN cord-018017-c8myq6bi 400 16 benefit benefit NN cord-018017-c8myq6bi 400 17 . . . cord-018017-c8myq6bi 401 1 This this DT cord-018017-c8myq6bi 401 2 means mean VBZ cord-018017-c8myq6bi 401 3 viruses virus NNS cord-018017-c8myq6bi 401 4 with with IN cord-018017-c8myq6bi 401 5 no no DT cord-018017-c8myq6bi 401 6 current current JJ cord-018017-c8myq6bi 401 7 pathology pathology NN cord-018017-c8myq6bi 401 8 represent represent VBP cord-018017-c8myq6bi 401 9 a a DT cord-018017-c8myq6bi 401 10 pre pre JJ cord-018017-c8myq6bi 401 11 - - JJ cord-018017-c8myq6bi 401 12 mutation mutation JJ cord-018017-c8myq6bi 401 13 reservoir reservoir NN cord-018017-c8myq6bi 401 14 for for IN cord-018017-c8myq6bi 401 15 the the DT cord-018017-c8myq6bi 401 16 next next JJ cord-018017-c8myq6bi 401 17 catastrophic catastrophic JJ cord-018017-c8myq6bi 401 18 human human JJ cord-018017-c8myq6bi 401 19 pandemic pandemic NN cord-018017-c8myq6bi 401 20 . . . cord-018017-c8myq6bi 402 1 The the DT cord-018017-c8myq6bi 402 2 popularity popularity NN cord-018017-c8myq6bi 402 3 of of IN cord-018017-c8myq6bi 402 4 RNAseq RNAseq NNP cord-018017-c8myq6bi 402 5 is be VBZ cord-018017-c8myq6bi 402 6 likely likely JJ cord-018017-c8myq6bi 402 7 to to TO cord-018017-c8myq6bi 402 8 expand expand VB cord-018017-c8myq6bi 402 9 our -PRON- PRP$ cord-018017-c8myq6bi 402 10 catalog catalog NN cord-018017-c8myq6bi 402 11 of of IN cord-018017-c8myq6bi 402 12 nonpathogenic nonpathogenic NNP cord-018017-c8myq6bi 402 13 viral viral JJ cord-018017-c8myq6bi 402 14 infections infection NNS cord-018017-c8myq6bi 402 15 . . . cord-018017-c8myq6bi 403 1 However however RB cord-018017-c8myq6bi 403 2 , , , cord-018017-c8myq6bi 403 3 the the DT cord-018017-c8myq6bi 403 4 management management NN cord-018017-c8myq6bi 403 5 of of IN cord-018017-c8myq6bi 403 6 such such JJ cord-018017-c8myq6bi 403 7 information information NN cord-018017-c8myq6bi 403 8 is be VBZ cord-018017-c8myq6bi 403 9 in in IN cord-018017-c8myq6bi 403 10 question question NN cord-018017-c8myq6bi 403 11 . . . cord-018017-c8myq6bi 404 1 Technology technology NN cord-018017-c8myq6bi 404 2 used use VBN cord-018017-c8myq6bi 404 3 to to TO cord-018017-c8myq6bi 404 4 counter counter VB cord-018017-c8myq6bi 404 5 viral viral JJ cord-018017-c8myq6bi 404 6 infections infection NNS cord-018017-c8myq6bi 404 7 has have VBZ cord-018017-c8myq6bi 404 8 resulted result VBN cord-018017-c8myq6bi 404 9 in in IN cord-018017-c8myq6bi 404 10 over over IN cord-018017-c8myq6bi 404 11 90 90 CD cord-018017-c8myq6bi 404 12 approved approve VBN cord-018017-c8myq6bi 404 13 drugs drug NNS cord-018017-c8myq6bi 404 14 for for IN cord-018017-c8myq6bi 404 15 the the DT cord-018017-c8myq6bi 404 16 treatment treatment NN cord-018017-c8myq6bi 404 17 of of IN cord-018017-c8myq6bi 404 18 nine nine CD cord-018017-c8myq6bi 404 19 different different JJ cord-018017-c8myq6bi 404 20 human human JJ cord-018017-c8myq6bi 404 21 viral viral JJ cord-018017-c8myq6bi 404 22 infections infection NNS cord-018017-c8myq6bi 404 23 in in IN cord-018017-c8myq6bi 404 24 just just RB cord-018017-c8myq6bi 404 25 50 50 CD cord-018017-c8myq6bi 404 26 years year NNS cord-018017-c8myq6bi 404 27 ( ( -LRB- cord-018017-c8myq6bi 404 28 De De NNP cord-018017-c8myq6bi 404 29 Clercq Clercq NNP cord-018017-c8myq6bi 404 30 and and CC cord-018017-c8myq6bi 404 31 Li Li NNP cord-018017-c8myq6bi 404 32 2016 2016 CD cord-018017-c8myq6bi 404 33 ) ) -RRB- cord-018017-c8myq6bi 404 34 . . . cord-018017-c8myq6bi 405 1 Several several JJ cord-018017-c8myq6bi 405 2 different different JJ cord-018017-c8myq6bi 405 3 antiviral antiviral JJ cord-018017-c8myq6bi 405 4 drug drug NN cord-018017-c8myq6bi 405 5 groupings grouping NNS cord-018017-c8myq6bi 405 6 have have VBP cord-018017-c8myq6bi 405 7 been be VBN cord-018017-c8myq6bi 405 8 reported report VBN cord-018017-c8myq6bi 405 9 , , , cord-018017-c8myq6bi 405 10 but but CC cord-018017-c8myq6bi 405 11 the the DT cord-018017-c8myq6bi 405 12 following follow VBG cord-018017-c8myq6bi 405 13 arise arise NN cord-018017-c8myq6bi 405 14 from from IN cord-018017-c8myq6bi 405 15 review review NN cord-018017-c8myq6bi 405 16 of of IN cord-018017-c8myq6bi 405 17 the the DT cord-018017-c8myq6bi 405 18 mechanisms mechanism NNS cord-018017-c8myq6bi 405 19 of of IN cord-018017-c8myq6bi 405 20 action action NN cord-018017-c8myq6bi 405 21 of of IN cord-018017-c8myq6bi 405 22 antiviral antiviral JJ cord-018017-c8myq6bi 405 23 drugs drug NNS cord-018017-c8myq6bi 405 24 assembled assemble VBN cord-018017-c8myq6bi 405 25 in in IN cord-018017-c8myq6bi 405 26 Table Table NNP cord-018017-c8myq6bi 405 27 3 3 CD cord-018017-c8myq6bi 405 28 .7 .7 NFP cord-018017-c8myq6bi 405 29 : : : cord-018017-c8myq6bi 406 1 ( ( -LRB- cord-018017-c8myq6bi 406 2 1 1 LS cord-018017-c8myq6bi 406 3 ) ) -RRB- cord-018017-c8myq6bi 406 4 Inhibition inhibition NN cord-018017-c8myq6bi 406 5 of of IN cord-018017-c8myq6bi 406 6 viral viral JJ cord-018017-c8myq6bi 406 7 attachment attachment NN cord-018017-c8myq6bi 406 8 and and CC cord-018017-c8myq6bi 406 9 entry entry NN cord-018017-c8myq6bi 406 10 , , , cord-018017-c8myq6bi 406 11 ( ( -LRB- cord-018017-c8myq6bi 406 12 2 2 LS cord-018017-c8myq6bi 406 13 ) ) -RRB- cord-018017-c8myq6bi 406 14 Inhibition inhibition NN cord-018017-c8myq6bi 406 15 of of IN cord-018017-c8myq6bi 406 16 viral viral JJ cord-018017-c8myq6bi 406 17 uncoating uncoating NN cord-018017-c8myq6bi 406 18 , , , cord-018017-c8myq6bi 406 19 ( ( -LRB- cord-018017-c8myq6bi 406 20 3 3 CD cord-018017-c8myq6bi 406 21 ) ) -RRB- cord-018017-c8myq6bi 407 1 Viral Viral NNP cord-018017-c8myq6bi 407 2 Polymerase Polymerase NNP cord-018017-c8myq6bi 407 3 Inhibitors Inhibitors NNP cord-018017-c8myq6bi 407 4 , , , cord-018017-c8myq6bi 407 5 Nucleotide nucleotide JJ cord-018017-c8myq6bi 407 6 analogues analogue NNS cord-018017-c8myq6bi 407 7 ( ( -LRB- cord-018017-c8myq6bi 407 8 NTRTI NTRTI NNP cord-018017-c8myq6bi 407 9 ) ) -RRB- cord-018017-c8myq6bi 407 10 and and CC cord-018017-c8myq6bi 407 11 Non Non NNP cord-018017-c8myq6bi 407 12 - - NNP cord-018017-c8myq6bi 407 13 Nucleotide nucleotide JJ cord-018017-c8myq6bi 407 14 Reverse Reverse NNP cord-018017-c8myq6bi 407 15 Transcriptase Transcriptase NNP cord-018017-c8myq6bi 407 16 Inhibitors Inhibitors NNP cord-018017-c8myq6bi 407 17 ( ( -LRB- cord-018017-c8myq6bi 407 18 NNRTI NNRTI NNP cord-018017-c8myq6bi 407 19 ) ) -RRB- cord-018017-c8myq6bi 407 20 and and CC cord-018017-c8myq6bi 407 21 DNA DNA NNP cord-018017-c8myq6bi 407 22 Polymerase Polymerase NNP cord-018017-c8myq6bi 407 23 Inhibitors Inhibitors NNP cord-018017-c8myq6bi 407 24 , , , cord-018017-c8myq6bi 407 25 Nucleic Nucleic NNP cord-018017-c8myq6bi 407 26 Acid Acid NNP cord-018017-c8myq6bi 407 27 Synthesis Synthesis NNP cord-018017-c8myq6bi 407 28 inhibitors inhibitor NNS cord-018017-c8myq6bi 407 29 and and CC cord-018017-c8myq6bi 407 30 Nucleotide Nucleotide NNP cord-018017-c8myq6bi 407 31 Pool Pool NNP cord-018017-c8myq6bi 407 32 Size Size NNP cord-018017-c8myq6bi 407 33 Agents Agents NNPS cord-018017-c8myq6bi 407 34 , , , cord-018017-c8myq6bi 407 35 ( ( -LRB- cord-018017-c8myq6bi 407 36 4 4 LS cord-018017-c8myq6bi 407 37 ) ) -RRB- cord-018017-c8myq6bi 408 1 Latency Latency NNP cord-018017-c8myq6bi 408 2 Reversal reversal NN cord-018017-c8myq6bi 408 3 Agents agent NNS cord-018017-c8myq6bi 408 4 , , , cord-018017-c8myq6bi 408 5 ( ( -LRB- cord-018017-c8myq6bi 408 6 5 5 LS cord-018017-c8myq6bi 408 7 ) ) -RRB- cord-018017-c8myq6bi 409 1 Integrase Integrase NNP cord-018017-c8myq6bi 409 2 Inhibitors Inhibitors NNP cord-018017-c8myq6bi 409 3 , , , cord-018017-c8myq6bi 409 4 ( ( -LRB- cord-018017-c8myq6bi 409 5 6 6 CD cord-018017-c8myq6bi 409 6 ) ) -RRB- cord-018017-c8myq6bi 410 1 Protease Protease NNP cord-018017-c8myq6bi 410 2 Inhibitors Inhibitors NNP cord-018017-c8myq6bi 410 3 for for IN cord-018017-c8myq6bi 410 4 both both CC cord-018017-c8myq6bi 410 5 HIV HIV NNP cord-018017-c8myq6bi 410 6 and and CC cord-018017-c8myq6bi 410 7 HCV HCV NNP cord-018017-c8myq6bi 410 8 , , , cord-018017-c8myq6bi 410 9 ( ( -LRB- cord-018017-c8myq6bi 410 10 7 7 CD cord-018017-c8myq6bi 410 11 ) ) -RRB- cord-018017-c8myq6bi 411 1 Neuraminidase Neuraminidase NNP cord-018017-c8myq6bi 411 2 Inhibitors Inhibitors NNP cord-018017-c8myq6bi 411 3 , , , cord-018017-c8myq6bi 411 4 ( ( -LRB- cord-018017-c8myq6bi 411 5 8) 8) LS cord-018017-c8myq6bi 411 6 Immune Immune NNP cord-018017-c8myq6bi 411 7 Response Response NNP cord-018017-c8myq6bi 411 8 Modifiers Modifiers NNPS cord-018017-c8myq6bi 411 9 , , , cord-018017-c8myq6bi 411 10 and and CC cord-018017-c8myq6bi 411 11 ( ( -LRB- cord-018017-c8myq6bi 411 12 9 9 CD cord-018017-c8myq6bi 411 13 ) ) -RRB- cord-018017-c8myq6bi 412 1 Antisense Antisense NNP cord-018017-c8myq6bi 412 2 Inhibitors Inhibitors NNP cord-018017-c8myq6bi 412 3 . . . cord-018017-c8myq6bi 412 4 _SP cord-018017-c8myq6bi 413 1 Administration Administration NNP cord-018017-c8myq6bi 413 2 of of IN cord-018017-c8myq6bi 413 3 hyperimmune hyperimmune NNP cord-018017-c8myq6bi 413 4 sera sera NNP cord-018017-c8myq6bi 413 5 from from IN cord-018017-c8myq6bi 413 6 immunized immunize VBN cord-018017-c8myq6bi 413 7 animals animal NNS cord-018017-c8myq6bi 413 8 or or CC cord-018017-c8myq6bi 413 9 human human JJ cord-018017-c8myq6bi 413 10 donors donor NNS cord-018017-c8myq6bi 413 11 was be VBD cord-018017-c8myq6bi 413 12 the the DT cord-018017-c8myq6bi 413 13 first first JJ cord-018017-c8myq6bi 413 14 effective effective JJ cord-018017-c8myq6bi 413 15 treatment treatment NN cord-018017-c8myq6bi 413 16 for for IN cord-018017-c8myq6bi 413 17 infectious infectious JJ cord-018017-c8myq6bi 413 18 diseases disease NNS cord-018017-c8myq6bi 413 19 . . . cord-018017-c8myq6bi 414 1 The the DT cord-018017-c8myq6bi 414 2 practice practice NN cord-018017-c8myq6bi 414 3 has have VBZ cord-018017-c8myq6bi 414 4 limitations limitation NNS cord-018017-c8myq6bi 414 5 but but CC cord-018017-c8myq6bi 414 6 is be VBZ cord-018017-c8myq6bi 414 7 still still RB cord-018017-c8myq6bi 414 8 used use VBN cord-018017-c8myq6bi 414 9 to to TO cord-018017-c8myq6bi 414 10 treat treat VB cord-018017-c8myq6bi 414 11 bacterial bacterial JJ cord-018017-c8myq6bi 414 12 toxins toxin NNS cord-018017-c8myq6bi 414 13 and and CC cord-018017-c8myq6bi 414 14 viral viral JJ cord-018017-c8myq6bi 414 15 infections infection NNS cord-018017-c8myq6bi 414 16 caused cause VBN cord-018017-c8myq6bi 414 17 by by IN cord-018017-c8myq6bi 414 18 CMV CMV NNP cord-018017-c8myq6bi 414 19 , , , cord-018017-c8myq6bi 414 20 RSV RSV NNP cord-018017-c8myq6bi 414 21 , , , cord-018017-c8myq6bi 414 22 HAV HAV NNP cord-018017-c8myq6bi 414 23 , , , cord-018017-c8myq6bi 414 24 HBV HBV NNP cord-018017-c8myq6bi 414 25 , , , cord-018017-c8myq6bi 414 26 RABV RABV NNP cord-018017-c8myq6bi 414 27 , , , cord-018017-c8myq6bi 414 28 VZV VZV NNP cord-018017-c8myq6bi 414 29 and and CC cord-018017-c8myq6bi 414 30 MEV MEV NNP cord-018017-c8myq6bi 414 31 ( ( -LRB- cord-018017-c8myq6bi 414 32 Keller Keller NNP cord-018017-c8myq6bi 414 33 and and CC cord-018017-c8myq6bi 414 34 Stiehm Stiehm NNP cord-018017-c8myq6bi 414 35 2000 2000 CD cord-018017-c8myq6bi 414 36 ) ) -RRB- cord-018017-c8myq6bi 414 37 . . . cord-018017-c8myq6bi 415 1 The the DT cord-018017-c8myq6bi 415 2 development development NN cord-018017-c8myq6bi 415 3 of of IN cord-018017-c8myq6bi 415 4 human human JJ cord-018017-c8myq6bi 415 5 or or CC cord-018017-c8myq6bi 415 6 humanized humanize VBN cord-018017-c8myq6bi 415 7 monoclonal monoclonal JJ cord-018017-c8myq6bi 415 8 antibodies antibody NNS cord-018017-c8myq6bi 415 9 ( ( -LRB- cord-018017-c8myq6bi 415 10 HumAbs HumAbs NNP cord-018017-c8myq6bi 415 11 ) ) -RRB- cord-018017-c8myq6bi 415 12 has have VBZ cord-018017-c8myq6bi 415 13 created create VBN cord-018017-c8myq6bi 415 14 a a DT cord-018017-c8myq6bi 415 15 feasible feasible JJ cord-018017-c8myq6bi 415 16 way way NN cord-018017-c8myq6bi 415 17 to to TO cord-018017-c8myq6bi 415 18 rapidly rapidly RB cord-018017-c8myq6bi 415 19 generate generate VB cord-018017-c8myq6bi 415 20 novel novel JJ cord-018017-c8myq6bi 415 21 antiviral antiviral JJ cord-018017-c8myq6bi 415 22 therapeutics therapeutic NNS cord-018017-c8myq6bi 415 23 . . . cord-018017-c8myq6bi 416 1 HumAbs humab NNS cord-018017-c8myq6bi 416 2 have have VBP cord-018017-c8myq6bi 416 3 advantages advantage NNS cord-018017-c8myq6bi 416 4 over over IN cord-018017-c8myq6bi 416 5 serum serum NN cord-018017-c8myq6bi 416 6 therapy therapy NN cord-018017-c8myq6bi 416 7 in in IN cord-018017-c8myq6bi 416 8 that that IN cord-018017-c8myq6bi 416 9 they -PRON- PRP cord-018017-c8myq6bi 416 10 are be VBP cord-018017-c8myq6bi 416 11 chemically chemically RB cord-018017-c8myq6bi 416 12 defined define VBN cord-018017-c8myq6bi 416 13 reagents reagent NNS cord-018017-c8myq6bi 416 14 with with IN cord-018017-c8myq6bi 416 15 minimal minimal JJ cord-018017-c8myq6bi 416 16 variability variability NN cord-018017-c8myq6bi 416 17 , , , cord-018017-c8myq6bi 416 18 greater great JJR cord-018017-c8myq6bi 416 19 activity activity NN cord-018017-c8myq6bi 416 20 per per IN cord-018017-c8myq6bi 416 21 mass mass NN cord-018017-c8myq6bi 416 22 of of IN cord-018017-c8myq6bi 416 23 protein protein NN cord-018017-c8myq6bi 416 24 , , , cord-018017-c8myq6bi 416 25 and and CC cord-018017-c8myq6bi 416 26 they -PRON- PRP cord-018017-c8myq6bi 416 27 have have VBP cord-018017-c8myq6bi 416 28 no no DT cord-018017-c8myq6bi 416 29 immunological immunological JJ cord-018017-c8myq6bi 416 30 consequences consequence NNS cord-018017-c8myq6bi 416 31 related relate VBN cord-018017-c8myq6bi 416 32 to to IN cord-018017-c8myq6bi 416 33 serum serum NN cord-018017-c8myq6bi 416 34 sickness sickness NN cord-018017-c8myq6bi 416 35 . . . cord-018017-c8myq6bi 417 1 Several several JJ cord-018017-c8myq6bi 417 2 mAbs mAbs NNP cord-018017-c8myq6bi 417 3 have have VBP cord-018017-c8myq6bi 417 4 been be VBN cord-018017-c8myq6bi 417 5 approved approve VBN cord-018017-c8myq6bi 417 6 for for IN cord-018017-c8myq6bi 417 7 treatment treatment NN cord-018017-c8myq6bi 417 8 of of IN cord-018017-c8myq6bi 417 9 infectious infectious JJ cord-018017-c8myq6bi 417 10 diseases disease NNS cord-018017-c8myq6bi 417 11 including include VBG cord-018017-c8myq6bi 417 12 viral viral JJ cord-018017-c8myq6bi 417 13 and and CC cord-018017-c8myq6bi 417 14 bacterial bacterial JJ cord-018017-c8myq6bi 417 15 pathogens pathogen NNS cord-018017-c8myq6bi 417 16 ( ( -LRB- cord-018017-c8myq6bi 417 17 Table table NN cord-018017-c8myq6bi 417 18 3 3 CD cord-018017-c8myq6bi 417 19 .8 .8 CD cord-018017-c8myq6bi 417 20 ) ) -RRB- cord-018017-c8myq6bi 417 21 . . . cord-018017-c8myq6bi 418 1 The the DT cord-018017-c8myq6bi 418 2 antiviral antiviral JJ cord-018017-c8myq6bi 418 3 mAb mab NN cord-018017-c8myq6bi 418 4 discovery discovery NN cord-018017-c8myq6bi 418 5 field field NN cord-018017-c8myq6bi 418 6 is be VBZ cord-018017-c8myq6bi 418 7 exploding explode VBG cord-018017-c8myq6bi 418 8 with with IN cord-018017-c8myq6bi 418 9 activity activity NN cord-018017-c8myq6bi 418 10 particularly particularly RB cord-018017-c8myq6bi 418 11 for for IN cord-018017-c8myq6bi 418 12 HIV HIV NNP cord-018017-c8myq6bi 418 13 and and CC cord-018017-c8myq6bi 418 14 HCV HCV NNP cord-018017-c8myq6bi 418 15 infections infection NNS cord-018017-c8myq6bi 418 16 . . . cord-018017-c8myq6bi 419 1 A a DT cord-018017-c8myq6bi 419 2 humanized humanized JJ cord-018017-c8myq6bi 419 3 mAb mab NN cord-018017-c8myq6bi 419 4 targeting target VBG cord-018017-c8myq6bi 419 5 lymphocyte lymphocyte NN cord-018017-c8myq6bi 419 6 CCR5 CCR5 NNP cord-018017-c8myq6bi 419 7 receptors receptor NNS cord-018017-c8myq6bi 419 8 called call VBD cord-018017-c8myq6bi 419 9 PRO140 PRO140 NNP cord-018017-c8myq6bi 419 10 has have VBZ cord-018017-c8myq6bi 419 11 demonstrated demonstrate VBN cord-018017-c8myq6bi 419 12 potent potent JJ cord-018017-c8myq6bi 419 13 and and CC cord-018017-c8myq6bi 419 14 prolonged prolonged JJ cord-018017-c8myq6bi 419 15 anti anti JJ cord-018017-c8myq6bi 419 16 - - JJ cord-018017-c8myq6bi 419 17 HIV-1 hiv-1 JJ cord-018017-c8myq6bi 419 18 activity activity NN cord-018017-c8myq6bi 419 19 and and CC cord-018017-c8myq6bi 419 20 a a DT cord-018017-c8myq6bi 419 21 large large JJ cord-018017-c8myq6bi 419 22 margin margin NN cord-018017-c8myq6bi 419 23 of of IN cord-018017-c8myq6bi 419 24 safety safety NN cord-018017-c8myq6bi 420 1 ( ( -LRB- cord-018017-c8myq6bi 420 2 Jacobson Jacobson NNP cord-018017-c8myq6bi 420 3 et et NNP cord-018017-c8myq6bi 420 4 al al NNP cord-018017-c8myq6bi 420 5 . . NNP cord-018017-c8myq6bi 420 6 2010a 2010a CD cord-018017-c8myq6bi 420 7 ) ) -RRB- cord-018017-c8myq6bi 420 8 . . . cord-018017-c8myq6bi 421 1 Administration Administration NNP cord-018017-c8myq6bi 421 2 of of IN cord-018017-c8myq6bi 421 3 PRO PRO NNP cord-018017-c8myq6bi 421 4 140 140 CD cord-018017-c8myq6bi 421 5 by by IN cord-018017-c8myq6bi 421 6 the the DT cord-018017-c8myq6bi 421 7 subcutaneous subcutaneous JJ cord-018017-c8myq6bi 421 8 route route NN cord-018017-c8myq6bi 421 9 offers offer VBZ cord-018017-c8myq6bi 421 10 patients patient NNS cord-018017-c8myq6bi 421 11 a a DT cord-018017-c8myq6bi 421 12 way way NN cord-018017-c8myq6bi 421 13 to to IN cord-018017-c8myq6bi 421 14 self self NN cord-018017-c8myq6bi 421 15 - - : cord-018017-c8myq6bi 421 16 administer administer VB cord-018017-c8myq6bi 421 17 the the DT cord-018017-c8myq6bi 421 18 mAb mAb NNS cord-018017-c8myq6bi 421 19 but but CC cord-018017-c8myq6bi 421 20 importantly importantly RB cord-018017-c8myq6bi 421 21 the the DT cord-018017-c8myq6bi 421 22 mAb mab NN cord-018017-c8myq6bi 421 23 is be VBZ cord-018017-c8myq6bi 421 24 transported transport VBN cord-018017-c8myq6bi 421 25 in in IN cord-018017-c8myq6bi 421 26 the the DT cord-018017-c8myq6bi 421 27 lymphatics lymphatic NNS cord-018017-c8myq6bi 421 28 providing provide VBG cord-018017-c8myq6bi 421 29 enhanced enhance VBN cord-018017-c8myq6bi 421 30 access access NN cord-018017-c8myq6bi 421 31 to to IN cord-018017-c8myq6bi 421 32 binding bind VBG cord-018017-c8myq6bi 421 33 to to IN cord-018017-c8myq6bi 421 34 the the DT cord-018017-c8myq6bi 421 35 cellular cellular JJ cord-018017-c8myq6bi 421 36 target target NN cord-018017-c8myq6bi 421 37 ( ( -LRB- cord-018017-c8myq6bi 421 38 Jacobson Jacobson NNP cord-018017-c8myq6bi 421 39 et et NNP cord-018017-c8myq6bi 421 40 al al NNP cord-018017-c8myq6bi 421 41 . . NNP cord-018017-c8myq6bi 421 42 2010b 2010b CD cord-018017-c8myq6bi 421 43 ) ) -RRB- cord-018017-c8myq6bi 421 44 . . . cord-018017-c8myq6bi 422 1 The the DT cord-018017-c8myq6bi 422 2 next next JJ cord-018017-c8myq6bi 422 3 generation generation NN cord-018017-c8myq6bi 422 4 of of IN cord-018017-c8myq6bi 422 5 antiviral antiviral JJ cord-018017-c8myq6bi 422 6 therapeutics therapeutic NNS cord-018017-c8myq6bi 422 7 are be VBP cord-018017-c8myq6bi 422 8 likely likely JJ cord-018017-c8myq6bi 422 9 to to TO cord-018017-c8myq6bi 422 10 be be VB cord-018017-c8myq6bi 422 11 dominated dominate VBN cord-018017-c8myq6bi 422 12 by by IN cord-018017-c8myq6bi 422 13 mAbs mAbs NNP cord-018017-c8myq6bi 422 14 . . . cord-018017-c8myq6bi 423 1 Perhaps perhaps RB cord-018017-c8myq6bi 423 2 the the DT cord-018017-c8myq6bi 423 3 only only JJ cord-018017-c8myq6bi 423 4 way way NN cord-018017-c8myq6bi 423 5 to to TO cord-018017-c8myq6bi 423 6 clear clear VB cord-018017-c8myq6bi 423 7 a a DT cord-018017-c8myq6bi 423 8 viral viral JJ cord-018017-c8myq6bi 423 9 infection infection NN cord-018017-c8myq6bi 423 10 involves involve VBZ cord-018017-c8myq6bi 423 11 a a DT cord-018017-c8myq6bi 423 12 host host NN cord-018017-c8myq6bi 423 13 immune immune JJ cord-018017-c8myq6bi 423 14 response response NN cord-018017-c8myq6bi 423 15 ( ( -LRB- cord-018017-c8myq6bi 423 16 Table table NN cord-018017-c8myq6bi 423 17 3 3 CD cord-018017-c8myq6bi 423 18 .9 .9 CD cord-018017-c8myq6bi 423 19 ) ) -RRB- cord-018017-c8myq6bi 423 20 . . . cord-018017-c8myq6bi 424 1 The the DT cord-018017-c8myq6bi 424 2 innate innate JJ cord-018017-c8myq6bi 424 3 immune immune JJ cord-018017-c8myq6bi 424 4 response response NN cord-018017-c8myq6bi 424 5 is be VBZ cord-018017-c8myq6bi 424 6 particularly particularly RB cord-018017-c8myq6bi 424 7 effective effective JJ cord-018017-c8myq6bi 424 8 centered center VBN cord-018017-c8myq6bi 424 9 on on IN cord-018017-c8myq6bi 424 10 a a DT cord-018017-c8myq6bi 424 11 type type NN cord-018017-c8myq6bi 424 12 1-interferon 1-interferon CD cord-018017-c8myq6bi 424 13 pathway pathway NN cord-018017-c8myq6bi 424 14 . . . cord-018017-c8myq6bi 425 1 Unfortunately unfortunately RB cord-018017-c8myq6bi 425 2 , , , cord-018017-c8myq6bi 425 3 many many JJ cord-018017-c8myq6bi 425 4 viruses virus NNS cord-018017-c8myq6bi 425 5 carry carry VBP cord-018017-c8myq6bi 425 6 mechanisms mechanism NNS cord-018017-c8myq6bi 425 7 to to TO cord-018017-c8myq6bi 425 8 evade evade VB cord-018017-c8myq6bi 425 9 host host NN cord-018017-c8myq6bi 425 10 innate innate JJ cord-018017-c8myq6bi 425 11 responses response NNS cord-018017-c8myq6bi 425 12 and and CC cord-018017-c8myq6bi 425 13 innate innate JJ cord-018017-c8myq6bi 425 14 immune immune JJ cord-018017-c8myq6bi 425 15 effectors effector NNS cord-018017-c8myq6bi 425 16 do do VBP cord-018017-c8myq6bi 425 17 not not RB cord-018017-c8myq6bi 425 18 have have VB cord-018017-c8myq6bi 425 19 the the DT cord-018017-c8myq6bi 425 20 capacity capacity NN cord-018017-c8myq6bi 425 21 for for IN cord-018017-c8myq6bi 425 22 memory memory NN cord-018017-c8myq6bi 425 23 . . . cord-018017-c8myq6bi 426 1 The the DT cord-018017-c8myq6bi 426 2 adaptive adaptive JJ cord-018017-c8myq6bi 426 3 immune immune JJ cord-018017-c8myq6bi 426 4 response response NN cord-018017-c8myq6bi 426 5 can can MD cord-018017-c8myq6bi 426 6 mitigate mitigate VB cord-018017-c8myq6bi 426 7 infection infection NN cord-018017-c8myq6bi 426 8 with with IN cord-018017-c8myq6bi 426 9 antibodies antibody NNS cord-018017-c8myq6bi 426 10 , , , cord-018017-c8myq6bi 426 11 generally generally RB cord-018017-c8myq6bi 426 12 to to TO cord-018017-c8myq6bi 426 13 surface surface VB cord-018017-c8myq6bi 426 14 antigens antigen NNS cord-018017-c8myq6bi 426 15 , , , cord-018017-c8myq6bi 426 16 which which WDT cord-018017-c8myq6bi 426 17 prevent prevent VBP cord-018017-c8myq6bi 426 18 the the DT cord-018017-c8myq6bi 426 19 spread spread NN cord-018017-c8myq6bi 426 20 of of IN cord-018017-c8myq6bi 426 21 the the DT cord-018017-c8myq6bi 426 22 virus virus NN cord-018017-c8myq6bi 426 23 and and CC cord-018017-c8myq6bi 426 24 T t NN cord-018017-c8myq6bi 426 25 - - HYPH cord-018017-c8myq6bi 426 26 lymphocytes lymphocyte NNS cord-018017-c8myq6bi 426 27 , , , cord-018017-c8myq6bi 426 28 which which WDT cord-018017-c8myq6bi 426 29 can can MD cord-018017-c8myq6bi 426 30 clear clear VB cord-018017-c8myq6bi 426 31 virus virus NN cord-018017-c8myq6bi 426 32 - - HYPH cord-018017-c8myq6bi 426 33 infected infect VBN cord-018017-c8myq6bi 426 34 cells cell NNS cord-018017-c8myq6bi 426 35 . . . cord-018017-c8myq6bi 427 1 The the DT cord-018017-c8myq6bi 427 2 first first JJ cord-018017-c8myq6bi 427 3 strategy strategy NN cord-018017-c8myq6bi 427 4 will will MD cord-018017-c8myq6bi 427 5 be be VB cord-018017-c8myq6bi 427 6 to to TO cord-018017-c8myq6bi 427 7 use use VB cord-018017-c8myq6bi 427 8 an an DT cord-018017-c8myq6bi 427 9 existing exist VBG cord-018017-c8myq6bi 427 10 drug drug NN cord-018017-c8myq6bi 427 11 designed design VBN cord-018017-c8myq6bi 427 12 for for IN cord-018017-c8myq6bi 427 13 another another DT cord-018017-c8myq6bi 427 14 virus virus NN cord-018017-c8myq6bi 427 15 offlabel offlabel NN cord-018017-c8myq6bi 427 16 . . . cord-018017-c8myq6bi 428 1 This this DT cord-018017-c8myq6bi 428 2 seems seem VBZ cord-018017-c8myq6bi 428 3 likely likely JJ cord-018017-c8myq6bi 428 4 for for IN cord-018017-c8myq6bi 428 5 antiviral antiviral JJ cord-018017-c8myq6bi 428 6 drugs drug NNS cord-018017-c8myq6bi 428 7 like like IN cord-018017-c8myq6bi 428 8 Cidofovir Cidofovir NNP cord-018017-c8myq6bi 428 9 , , , cord-018017-c8myq6bi 428 10 Foscarnet Foscarnet NNP cord-018017-c8myq6bi 428 11 , , , cord-018017-c8myq6bi 428 12 and and CC cord-018017-c8myq6bi 428 13 Ganciclovir Ganciclovir NNP cord-018017-c8myq6bi 428 14 particularly particularly RB cord-018017-c8myq6bi 428 15 for for IN cord-018017-c8myq6bi 428 16 double double RB cord-018017-c8myq6bi 428 17 - - HYPH cord-018017-c8myq6bi 428 18 stranded strand VBN cord-018017-c8myq6bi 428 19 DNA dna NN cord-018017-c8myq6bi 428 20 viruses virus NNS cord-018017-c8myq6bi 428 21 like like IN cord-018017-c8myq6bi 428 22 EBV EBV NNP cord-018017-c8myq6bi 428 23 , , , cord-018017-c8myq6bi 428 24 HPV HPV NNP cord-018017-c8myq6bi 428 25 , , , cord-018017-c8myq6bi 428 26 and and CC cord-018017-c8myq6bi 428 27 HHV6 HHV6 NNP cord-018017-c8myq6bi 428 28 . . . cord-018017-c8myq6bi 429 1 Ribaviran Ribaviran NNP cord-018017-c8myq6bi 429 2 has have VBZ cord-018017-c8myq6bi 429 3 been be VBN cord-018017-c8myq6bi 429 4 used use VBN cord-018017-c8myq6bi 429 5 for for IN cord-018017-c8myq6bi 429 6 a a DT cord-018017-c8myq6bi 429 7 number number NN cord-018017-c8myq6bi 429 8 of of IN cord-018017-c8myq6bi 429 9 single single RB cord-018017-c8myq6bi 429 10 - - HYPH cord-018017-c8myq6bi 429 11 stranded strand VBN cord-018017-c8myq6bi 429 12 RNA RNA NNP cord-018017-c8myq6bi 429 13 viruses virus NNS cord-018017-c8myq6bi 429 14 including include VBG cord-018017-c8myq6bi 429 15 polio polio NN cord-018017-c8myq6bi 429 16 , , , cord-018017-c8myq6bi 429 17 Junin Junin NNP cord-018017-c8myq6bi 429 18 , , , cord-018017-c8myq6bi 429 19 and and CC cord-018017-c8myq6bi 429 20 Lassa Lassa NNP cord-018017-c8myq6bi 429 21 Fever Fever NNP cord-018017-c8myq6bi 429 22 . . . cord-018017-c8myq6bi 430 1 Secondary secondary JJ cord-018017-c8myq6bi 430 2 strategies strategy NNS cord-018017-c8myq6bi 430 3 will will MD cord-018017-c8myq6bi 430 4 require require VB cord-018017-c8myq6bi 430 5 investment investment NN cord-018017-c8myq6bi 430 6 of of IN cord-018017-c8myq6bi 430 7 time time NN cord-018017-c8myq6bi 430 8 and and CC cord-018017-c8myq6bi 430 9 effort effort NN cord-018017-c8myq6bi 430 10 beginning begin VBG cord-018017-c8myq6bi 430 11 with with IN cord-018017-c8myq6bi 430 12 vaccine vaccine NN cord-018017-c8myq6bi 430 13 development development NN cord-018017-c8myq6bi 430 14 and and CC cord-018017-c8myq6bi 430 15 creation creation NN cord-018017-c8myq6bi 430 16 of of IN cord-018017-c8myq6bi 430 17 monoclonal monoclonal JJ cord-018017-c8myq6bi 430 18 antibodies antibody NNS cord-018017-c8myq6bi 430 19 . . . cord-018017-c8myq6bi 431 1 Platform Platform NNP cord-018017-c8myq6bi 431 2 Technology Technology NNP cord-018017-c8myq6bi 431 3 RNA RNA NNP cord-018017-c8myq6bi 431 4 - - HYPH cord-018017-c8myq6bi 431 5 based base VBN cord-018017-c8myq6bi 431 6 therapeutics therapeutic NNS cord-018017-c8myq6bi 431 7 offer offer VBP cord-018017-c8myq6bi 431 8 rational rational JJ cord-018017-c8myq6bi 431 9 design design NN cord-018017-c8myq6bi 431 10 for for IN cord-018017-c8myq6bi 431 11 an an DT cord-018017-c8myq6bi 431 12 expansive expansive JJ cord-018017-c8myq6bi 431 13 number number NN cord-018017-c8myq6bi 431 14 of of IN cord-018017-c8myq6bi 431 15 new new JJ cord-018017-c8myq6bi 431 16 antiviral antiviral JJ cord-018017-c8myq6bi 431 17 strategies strategy NNS cord-018017-c8myq6bi 431 18 . . . cord-018017-c8myq6bi 432 1 This this DT cord-018017-c8myq6bi 432 2 advantage advantage NN cord-018017-c8myq6bi 432 3 is be VBZ cord-018017-c8myq6bi 432 4 superimposed superimpose VBN cord-018017-c8myq6bi 432 5 on on IN cord-018017-c8myq6bi 432 6 the the DT cord-018017-c8myq6bi 432 7 theoretical theoretical JJ cord-018017-c8myq6bi 432 8 advantages advantage NNS cord-018017-c8myq6bi 432 9 of of IN cord-018017-c8myq6bi 432 10 selectivity selectivity NN cord-018017-c8myq6bi 432 11 , , , cord-018017-c8myq6bi 432 12 specificity specificity NN cord-018017-c8myq6bi 432 13 and and CC cord-018017-c8myq6bi 432 14 affinity affinity NN cord-018017-c8myq6bi 432 15 provided provide VBN cord-018017-c8myq6bi 432 16 by by IN cord-018017-c8myq6bi 432 17 Watson Watson NNP cord-018017-c8myq6bi 432 18 - - HYPH cord-018017-c8myq6bi 432 19 Crick Crick NNP cord-018017-c8myq6bi 432 20 base base NN cord-018017-c8myq6bi 432 21 pairing pairing NN cord-018017-c8myq6bi 432 22 . . . cord-018017-c8myq6bi 433 1 RNA RNA NNP cord-018017-c8myq6bi 433 2 - - HYPH cord-018017-c8myq6bi 433 3 based base VBN cord-018017-c8myq6bi 433 4 therapeutics therapeutic NNS cord-018017-c8myq6bi 433 5 are be VBP cord-018017-c8myq6bi 433 6 expected expect VBN cord-018017-c8myq6bi 433 7 to to TO cord-018017-c8myq6bi 433 8 provide provide VB cord-018017-c8myq6bi 433 9 a a DT cord-018017-c8myq6bi 433 10 substantially substantially RB cord-018017-c8myq6bi 433 11 more more RBR cord-018017-c8myq6bi 433 12 narrow narrow JJ cord-018017-c8myq6bi 433 13 range range NN cord-018017-c8myq6bi 433 14 of of IN cord-018017-c8myq6bi 433 15 pharmacokinetic pharmacokinetic JJ cord-018017-c8myq6bi 433 16 properties property NNS cord-018017-c8myq6bi 433 17 and and CC cord-018017-c8myq6bi 433 18 toxicities toxicity NNS cord-018017-c8myq6bi 433 19 thus thus RB cord-018017-c8myq6bi 433 20 are be VBP cord-018017-c8myq6bi 433 21 easier easy JJR cord-018017-c8myq6bi 433 22 to to TO cord-018017-c8myq6bi 433 23 compare compare VB cord-018017-c8myq6bi 433 24 to to IN cord-018017-c8myq6bi 433 25 each each DT cord-018017-c8myq6bi 433 26 other other JJ cord-018017-c8myq6bi 433 27 and and CC cord-018017-c8myq6bi 433 28 ultimately ultimately RB cord-018017-c8myq6bi 433 29 combine combine VB cord-018017-c8myq6bi 433 30 into into IN cord-018017-c8myq6bi 433 31 multi multi JJ cord-018017-c8myq6bi 433 32 - - JJ cord-018017-c8myq6bi 433 33 agent agent JJ cord-018017-c8myq6bi 433 34 cocktails cocktail NNS cord-018017-c8myq6bi 433 35 . . . cord-018017-c8myq6bi 434 1 However however RB cord-018017-c8myq6bi 434 2 , , , cord-018017-c8myq6bi 434 3 the the DT cord-018017-c8myq6bi 434 4 mechanism mechanism NN cord-018017-c8myq6bi 434 5 of of IN cord-018017-c8myq6bi 434 6 action action NN cord-018017-c8myq6bi 434 7 may may MD cord-018017-c8myq6bi 434 8 vary vary VB cord-018017-c8myq6bi 434 9 from from IN cord-018017-c8myq6bi 434 10 RNAse RNAse NNP cord-018017-c8myq6bi 434 11 H H NNP cord-018017-c8myq6bi 434 12 or or CC cord-018017-c8myq6bi 434 13 RISC RISC NNP cord-018017-c8myq6bi 434 14 mediated mediate VBD cord-018017-c8myq6bi 434 15 degradation degradation NN cord-018017-c8myq6bi 434 16 of of IN cord-018017-c8myq6bi 434 17 the the DT cord-018017-c8myq6bi 434 18 targeted target VBN cord-018017-c8myq6bi 434 19 RNA RNA NNP cord-018017-c8myq6bi 434 20 or or CC cord-018017-c8myq6bi 434 21 steric steric JJ cord-018017-c8myq6bi 434 22 inhibition inhibition NN cord-018017-c8myq6bi 434 23 of of IN cord-018017-c8myq6bi 434 24 RNA RNA NNP cord-018017-c8myq6bi 434 25 function function NN cord-018017-c8myq6bi 434 26 . . . cord-018017-c8myq6bi 435 1 The the DT cord-018017-c8myq6bi 435 2 objectives objective NNS cord-018017-c8myq6bi 435 3 of of IN cord-018017-c8myq6bi 435 4 our -PRON- PRP$ cord-018017-c8myq6bi 435 5 antiviral antiviral JJ cord-018017-c8myq6bi 435 6 program program NN cord-018017-c8myq6bi 435 7 have have VBP cord-018017-c8myq6bi 435 8 been be VBN cord-018017-c8myq6bi 435 9 to to TO cord-018017-c8myq6bi 435 10 exploit exploit VB cord-018017-c8myq6bi 435 11 the the DT cord-018017-c8myq6bi 435 12 broad broad JJ cord-018017-c8myq6bi 435 13 understanding understanding NN cord-018017-c8myq6bi 435 14 of of IN cord-018017-c8myq6bi 435 15 RNA RNA NNP cord-018017-c8myq6bi 435 16 - - HYPH cord-018017-c8myq6bi 435 17 based base VBN cord-018017-c8myq6bi 435 18 therapeutics therapeutic NNS cord-018017-c8myq6bi 435 19 for for IN cord-018017-c8myq6bi 435 20 antiviral antiviral JJ cord-018017-c8myq6bi 435 21 activity activity NN cord-018017-c8myq6bi 435 22 with with IN cord-018017-c8myq6bi 435 23 a a DT cord-018017-c8myq6bi 435 24 common common JJ cord-018017-c8myq6bi 435 25 chemical chemical NN cord-018017-c8myq6bi 435 26 type type NN cord-018017-c8myq6bi 435 27 , , , cord-018017-c8myq6bi 435 28 the the DT cord-018017-c8myq6bi 435 29 phosphorodiamidate phosphorodiamidate NNP cord-018017-c8myq6bi 435 30 morpholino morpholino NNP cord-018017-c8myq6bi 435 31 oliogmer oliogmer NNP cord-018017-c8myq6bi 435 32 ( ( -LRB- cord-018017-c8myq6bi 435 33 PMO PMO NNP cord-018017-c8myq6bi 435 34 ) ) -RRB- cord-018017-c8myq6bi 435 35 and and CC cord-018017-c8myq6bi 435 36 their -PRON- PRP$ cord-018017-c8myq6bi 435 37 enhanced enhance VBN cord-018017-c8myq6bi 435 38 derivatives derivative NNS cord-018017-c8myq6bi 435 39 . . . cord-018017-c8myq6bi 436 1 In in IN cord-018017-c8myq6bi 436 2 this this DT cord-018017-c8myq6bi 436 3 way way NN cord-018017-c8myq6bi 436 4 the the DT cord-018017-c8myq6bi 436 5 mechanism mechanism NN cord-018017-c8myq6bi 436 6 of of IN cord-018017-c8myq6bi 436 7 action action NN cord-018017-c8myq6bi 436 8 is be VBZ cord-018017-c8myq6bi 436 9 common common JJ cord-018017-c8myq6bi 436 10 to to IN cord-018017-c8myq6bi 436 11 all all DT cord-018017-c8myq6bi 436 12 agents agent NNS cord-018017-c8myq6bi 436 13 , , , cord-018017-c8myq6bi 436 14 which which WDT cord-018017-c8myq6bi 436 15 is be VBZ cord-018017-c8myq6bi 436 16 steric steric JJ cord-018017-c8myq6bi 436 17 blockade blockade NN cord-018017-c8myq6bi 436 18 of of IN cord-018017-c8myq6bi 436 19 RNA RNA NNP cord-018017-c8myq6bi 436 20 function function NN cord-018017-c8myq6bi 436 21 . . . cord-018017-c8myq6bi 437 1 Studies study NNS cord-018017-c8myq6bi 437 2 reported report VBN cord-018017-c8myq6bi 437 3 by by IN cord-018017-c8myq6bi 437 4 Zamecnik Zamecnik NNP cord-018017-c8myq6bi 437 5 and and CC cord-018017-c8myq6bi 437 6 Stevenson Stevenson NNP cord-018017-c8myq6bi 437 7 introduced introduce VBD cord-018017-c8myq6bi 437 8 the the DT cord-018017-c8myq6bi 437 9 first first JJ cord-018017-c8myq6bi 437 10 approach approach NN cord-018017-c8myq6bi 437 11 to to IN cord-018017-c8myq6bi 437 12 identification identification NN cord-018017-c8myq6bi 437 13 of of IN cord-018017-c8myq6bi 437 14 an an DT cord-018017-c8myq6bi 437 15 antisense antisense NN cord-018017-c8myq6bi 437 16 antiviral antiviral JJ cord-018017-c8myq6bi 437 17 agent agent NN cord-018017-c8myq6bi 437 18 Stephenson Stephenson NNP cord-018017-c8myq6bi 437 19 and and CC cord-018017-c8myq6bi 437 20 Zamecnik Zamecnik NNP cord-018017-c8myq6bi 437 21 1978 1978 CD cord-018017-c8myq6bi 437 22 ) ) -RRB- cord-018017-c8myq6bi 437 23 . . . cord-018017-c8myq6bi 438 1 They -PRON- PRP cord-018017-c8myq6bi 438 2 used use VBD cord-018017-c8myq6bi 438 3 a a DT cord-018017-c8myq6bi 438 4 13-mer 13-mer CD cord-018017-c8myq6bi 438 5 targeted target VBN cord-018017-c8myq6bi 438 6 to to IN cord-018017-c8myq6bi 438 7 Rous rous JJ cord-018017-c8myq6bi 438 8 sarcoma sarcoma NN cord-018017-c8myq6bi 438 9 virus virus NN cord-018017-c8myq6bi 438 10 . . . cord-018017-c8myq6bi 439 1 Since since IN cord-018017-c8myq6bi 439 2 the the DT cord-018017-c8myq6bi 439 3 Rous rous JJ cord-018017-c8myq6bi 439 4 sarcoma sarcoma NN cord-018017-c8myq6bi 439 5 virus virus NN cord-018017-c8myq6bi 439 6 pioneering pioneering JJ cord-018017-c8myq6bi 439 7 efforts effort NNS cord-018017-c8myq6bi 439 8 , , , cord-018017-c8myq6bi 439 9 antiviral antiviral JJ cord-018017-c8myq6bi 439 10 RNA RNA NNP cord-018017-c8myq6bi 439 11 based base VBN cord-018017-c8myq6bi 439 12 therapeutics therapeutic NNS cord-018017-c8myq6bi 439 13 have have VBP cord-018017-c8myq6bi 439 14 involved involve VBN cord-018017-c8myq6bi 439 15 multiple multiple JJ cord-018017-c8myq6bi 439 16 oligomer oligomer NNP cord-018017-c8myq6bi 439 17 chemistries chemistry NNS cord-018017-c8myq6bi 439 18 with with IN cord-018017-c8myq6bi 439 19 a a DT cord-018017-c8myq6bi 439 20 variety variety NN cord-018017-c8myq6bi 439 21 of of IN cord-018017-c8myq6bi 439 22 different different JJ cord-018017-c8myq6bi 439 23 mechanisms mechanism NNS cord-018017-c8myq6bi 439 24 of of IN cord-018017-c8myq6bi 439 25 action action NN cord-018017-c8myq6bi 439 26 . . . cord-018017-c8myq6bi 440 1 Chemical chemical NN cord-018017-c8myq6bi 440 2 approaches approach NNS cord-018017-c8myq6bi 440 3 to to IN cord-018017-c8myq6bi 440 4 oligomers oligomer NNS cord-018017-c8myq6bi 440 5 directed direct VBN cord-018017-c8myq6bi 440 6 to to IN cord-018017-c8myq6bi 440 7 HIV HIV NNP cord-018017-c8myq6bi 440 8 have have VBP cord-018017-c8myq6bi 440 9 been be VBN cord-018017-c8myq6bi 440 10 plentiful plentiful JJ cord-018017-c8myq6bi 440 11 . . . cord-018017-c8myq6bi 441 1 A a DT cord-018017-c8myq6bi 441 2 nonionic nonionic JJ cord-018017-c8myq6bi 441 3 methylphosphonate methylphosphonate NN cord-018017-c8myq6bi 441 4 oligonucleotide oligonucleotide NNP cord-018017-c8myq6bi 441 5 targeted target VBN cord-018017-c8myq6bi 441 6 to to IN cord-018017-c8myq6bi 441 7 the the DT cord-018017-c8myq6bi 441 8 splice splice NN cord-018017-c8myq6bi 441 9 acceptor acceptor NN cord-018017-c8myq6bi 441 10 site site NN cord-018017-c8myq6bi 441 11 of of IN cord-018017-c8myq6bi 441 12 HIV HIV NNP cord-018017-c8myq6bi 441 13 tat tat IN cord-018017-c8myq6bi 441 14 inhibited inhibit VBN cord-018017-c8myq6bi 441 15 splicing splicing NN cord-018017-c8myq6bi 441 16 of of IN cord-018017-c8myq6bi 441 17 viral viral JJ cord-018017-c8myq6bi 441 18 RNA RNA NNP cord-018017-c8myq6bi 441 19 inhibiting inhibit VBG cord-018017-c8myq6bi 441 20 syncytia syncytia NN cord-018017-c8myq6bi 441 21 formation formation NN cord-018017-c8myq6bi 441 22 and and CC cord-018017-c8myq6bi 441 23 p24 p24 NN cord-018017-c8myq6bi 441 24 synthesis synthesis NN cord-018017-c8myq6bi 441 25 at at IN cord-018017-c8myq6bi 441 26 3uM 3um CD cord-018017-c8myq6bi 441 27 concentration concentration NN cord-018017-c8myq6bi 441 28 . . . cord-018017-c8myq6bi 442 1 Poor poor JJ cord-018017-c8myq6bi 442 2 aqueous aqueous JJ cord-018017-c8myq6bi 442 3 solubility solubility NN cord-018017-c8myq6bi 442 4 limited limit VBD cord-018017-c8myq6bi 442 5 the the DT cord-018017-c8myq6bi 442 6 utility utility NN cord-018017-c8myq6bi 442 7 of of IN cord-018017-c8myq6bi 442 8 the the DT cord-018017-c8myq6bi 442 9 methylphosphonate methylphosphonate NNP cord-018017-c8myq6bi 442 10 chemistry chemistry NNP cord-018017-c8myq6bi 442 11 . . . cord-018017-c8myq6bi 443 1 Phosphoramidate Phosphoramidate NNP cord-018017-c8myq6bi 443 2 chemistry chemistry NN cord-018017-c8myq6bi 443 3 was be VBD cord-018017-c8myq6bi 443 4 investigated investigate VBN cord-018017-c8myq6bi 443 5 for for IN cord-018017-c8myq6bi 443 6 inhibition inhibition NN cord-018017-c8myq6bi 443 7 of of IN cord-018017-c8myq6bi 443 8 the the DT cord-018017-c8myq6bi 443 9 splice splice NN cord-018017-c8myq6bi 443 10 - - HYPH cord-018017-c8myq6bi 443 11 donor donor NN cord-018017-c8myq6bi 443 12 and and CC cord-018017-c8myq6bi 443 13 splice splice NN cord-018017-c8myq6bi 443 14 - - HYPH cord-018017-c8myq6bi 443 15 acceptor acceptor NN cord-018017-c8myq6bi 443 16 of of IN cord-018017-c8myq6bi 443 17 HIV HIV NNP cord-018017-c8myq6bi 443 18 tat tat NNP cord-018017-c8myq6bi 443 19 Agrawal Agrawal NNP cord-018017-c8myq6bi 443 20 et et NNP cord-018017-c8myq6bi 443 21 al al NNP cord-018017-c8myq6bi 443 22 . . . cord-018017-c8myq6bi 443 23 1988 1988 CD cord-018017-c8myq6bi 443 24 ) ) -RRB- cord-018017-c8myq6bi 443 25 and and CC cord-018017-c8myq6bi 443 26 were be VBD cord-018017-c8myq6bi 443 27 more more RBR cord-018017-c8myq6bi 443 28 potent potent JJ cord-018017-c8myq6bi 443 29 but but CC cord-018017-c8myq6bi 443 30 these these DT cord-018017-c8myq6bi 443 31 agents agent NNS cord-018017-c8myq6bi 443 32 were be VBD cord-018017-c8myq6bi 443 33 cytotoxic cytotoxic JJ cord-018017-c8myq6bi 443 34 and and CC cord-018017-c8myq6bi 443 35 poorly poorly RB cord-018017-c8myq6bi 443 36 water water NN cord-018017-c8myq6bi 443 37 soluble soluble JJ cord-018017-c8myq6bi 443 38 . . . cord-018017-c8myq6bi 444 1 Phosphorothioate phosphorothioate NN cord-018017-c8myq6bi 444 2 chemistry chemistry NN cord-018017-c8myq6bi 444 3 targeting target VBG cord-018017-c8myq6bi 444 4 HIV HIV NNP cord-018017-c8myq6bi 444 5 - - HYPH cord-018017-c8myq6bi 444 6 rev rev NNP cord-018017-c8myq6bi 444 7 ( ( -LRB- cord-018017-c8myq6bi 444 8 Matsukura Matsukura NNP cord-018017-c8myq6bi 444 9 et et NNP cord-018017-c8myq6bi 444 10 al al NNP cord-018017-c8myq6bi 444 11 . . NNP cord-018017-c8myq6bi 444 12 1987 1987 CD cord-018017-c8myq6bi 444 13 ) ) -RRB- cord-018017-c8myq6bi 444 14 and and CC cord-018017-c8myq6bi 444 15 HIV HIV NNP cord-018017-c8myq6bi 444 16 - - HYPH cord-018017-c8myq6bi 444 17 tat tat NNP cord-018017-c8myq6bi 444 18 were be VBD cord-018017-c8myq6bi 444 19 shown show VBN cord-018017-c8myq6bi 444 20 to to TO cord-018017-c8myq6bi 444 21 be be VB cord-018017-c8myq6bi 444 22 effective effective JJ cord-018017-c8myq6bi 444 23 in in IN cord-018017-c8myq6bi 444 24 inhibiting inhibit VBG cord-018017-c8myq6bi 444 25 HIV HIV NNP cord-018017-c8myq6bi 444 26 replication replication NN cord-018017-c8myq6bi 444 27 , , , cord-018017-c8myq6bi 444 28 were be VBD cord-018017-c8myq6bi 444 29 not not RB cord-018017-c8myq6bi 444 30 cytotoxic cytotoxic JJ cord-018017-c8myq6bi 444 31 and and CC cord-018017-c8myq6bi 444 32 were be VBD cord-018017-c8myq6bi 444 33 very very RB cord-018017-c8myq6bi 444 34 soluble soluble JJ cord-018017-c8myq6bi 444 35 . . . cord-018017-c8myq6bi 445 1 Further further RB cord-018017-c8myq6bi 445 2 , , , cord-018017-c8myq6bi 445 3 the the DT cord-018017-c8myq6bi 445 4 HIV HIV NNP cord-018017-c8myq6bi 445 5 - - HYPH cord-018017-c8myq6bi 445 6 rev rev NNP cord-018017-c8myq6bi 445 7 phosphorothioate phosphorothioate NNP cord-018017-c8myq6bi 445 8 oligodeoxynucleotide oligodeoxynucleotide NNP cord-018017-c8myq6bi 445 9 was be VBD cord-018017-c8myq6bi 445 10 stable stable JJ cord-018017-c8myq6bi 445 11 in in IN cord-018017-c8myq6bi 445 12 vivo vivo NN cord-018017-c8myq6bi 445 13 with with IN cord-018017-c8myq6bi 445 14 an an DT cord-018017-c8myq6bi 445 15 acceptable acceptable JJ cord-018017-c8myq6bi 445 16 pharmacokinetic pharmacokinetic JJ cord-018017-c8myq6bi 445 17 profile profile NN cord-018017-c8myq6bi 445 18 ( ( -LRB- cord-018017-c8myq6bi 445 19 Iversen Iversen NNP cord-018017-c8myq6bi 445 20 et et NNP cord-018017-c8myq6bi 445 21 al al NNP cord-018017-c8myq6bi 445 22 . . . cord-018017-c8myq6bi 445 23 1994 1994 CD cord-018017-c8myq6bi 445 24 ) ) -RRB- cord-018017-c8myq6bi 445 25 . . . cord-018017-c8myq6bi 446 1 A a DT cord-018017-c8myq6bi 446 2 25-mer 25-mer CD cord-018017-c8myq6bi 446 3 phoshorothioate phoshorothioate NN cord-018017-c8myq6bi 446 4 called call VBN cord-018017-c8myq6bi 446 5 GEM91 GEM91 NNP cord-018017-c8myq6bi 446 6 targeting target VBG cord-018017-c8myq6bi 446 7 the the DT cord-018017-c8myq6bi 446 8 initiation initiation NN cord-018017-c8myq6bi 446 9 site site NN cord-018017-c8myq6bi 446 10 of of IN cord-018017-c8myq6bi 446 11 HIV HIV NNP cord-018017-c8myq6bi 446 12 - - HYPH cord-018017-c8myq6bi 446 13 gag gag NN cord-018017-c8myq6bi 446 14 was be VBD cord-018017-c8myq6bi 446 15 evaluated evaluate VBN cord-018017-c8myq6bi 446 16 in in IN cord-018017-c8myq6bi 446 17 clinical clinical JJ cord-018017-c8myq6bi 446 18 trials trial NNS cord-018017-c8myq6bi 446 19 ( ( -LRB- cord-018017-c8myq6bi 446 20 Agrawal Agrawal NNP cord-018017-c8myq6bi 446 21 1998 1998 CD cord-018017-c8myq6bi 446 22 ) ) -RRB- cord-018017-c8myq6bi 446 23 but but CC cord-018017-c8myq6bi 446 24 the the DT cord-018017-c8myq6bi 446 25 trials trial NNS cord-018017-c8myq6bi 446 26 were be VBD cord-018017-c8myq6bi 446 27 discontinued discontinue VBN cord-018017-c8myq6bi 446 28 . . . cord-018017-c8myq6bi 447 1 I -PRON- PRP cord-018017-c8myq6bi 447 2 focused focus VBD cord-018017-c8myq6bi 447 3 on on IN cord-018017-c8myq6bi 447 4 phosphorodiamidate phosphorodiamidate NNP cord-018017-c8myq6bi 447 5 morpholino morpholino NNP cord-018017-c8myq6bi 447 6 oligomer oligomer NNP cord-018017-c8myq6bi 447 7 chemistry chemistry NN cord-018017-c8myq6bi 447 8 which which WDT cord-018017-c8myq6bi 447 9 is be VBZ cord-018017-c8myq6bi 447 10 both both DT cord-018017-c8myq6bi 447 11 stable stable JJ cord-018017-c8myq6bi 447 12 and and CC cord-018017-c8myq6bi 447 13 net net JJ cord-018017-c8myq6bi 447 14 - - HYPH cord-018017-c8myq6bi 447 15 neutral neutral JJ cord-018017-c8myq6bi 447 16 in in IN cord-018017-c8myq6bi 447 17 charge charge NN cord-018017-c8myq6bi 447 18 at at IN cord-018017-c8myq6bi 447 19 physiological physiological JJ cord-018017-c8myq6bi 447 20 pH. pH. NNP cord-018017-c8myq6bi 447 21 Single Single NNP cord-018017-c8myq6bi 447 22 Stranded Stranded NNP cord-018017-c8myq6bi 447 23 RNA RNA NNP cord-018017-c8myq6bi 447 24 Viruses virus NNS cord-018017-c8myq6bi 447 25 with with IN cord-018017-c8myq6bi 447 26 Positive positive JJ cord-018017-c8myq6bi 447 27 Sense sense NN cord-018017-c8myq6bi 447 28 ( ( -LRB- cord-018017-c8myq6bi 447 29 ssRNA(+ ssRNA(+ NNP cord-018017-c8myq6bi 447 30 ) ) -RRB- cord-018017-c8myq6bi 447 31 ) ) -RRB- cord-018017-c8myq6bi 448 1 These these DT cord-018017-c8myq6bi 448 2 viruses virus NNS cord-018017-c8myq6bi 448 3 are be VBP cord-018017-c8myq6bi 448 4 the the DT cord-018017-c8myq6bi 448 5 most most RBS cord-018017-c8myq6bi 448 6 simple simple JJ cord-018017-c8myq6bi 448 7 in in IN cord-018017-c8myq6bi 448 8 terms term NNS cord-018017-c8myq6bi 448 9 of of IN cord-018017-c8myq6bi 448 10 genome genome NN cord-018017-c8myq6bi 448 11 size size NN cord-018017-c8myq6bi 448 12 , , , cord-018017-c8myq6bi 448 13 number number NN cord-018017-c8myq6bi 448 14 of of IN cord-018017-c8myq6bi 448 15 potential potential JJ cord-018017-c8myq6bi 448 16 translated translate VBN cord-018017-c8myq6bi 448 17 viral viral JJ cord-018017-c8myq6bi 448 18 proteins protein NNS cord-018017-c8myq6bi 448 19 , , , cord-018017-c8myq6bi 448 20 their -PRON- PRP$ cord-018017-c8myq6bi 448 21 genomes genome NNS cord-018017-c8myq6bi 448 22 are be VBP cord-018017-c8myq6bi 448 23 all all RB cord-018017-c8myq6bi 448 24 linear linear JJ cord-018017-c8myq6bi 448 25 and and CC cord-018017-c8myq6bi 448 26 they -PRON- PRP cord-018017-c8myq6bi 448 27 enter enter VBP cord-018017-c8myq6bi 448 28 the the DT cord-018017-c8myq6bi 448 29 cell cell NN cord-018017-c8myq6bi 448 30 ready ready JJ cord-018017-c8myq6bi 448 31 for for IN cord-018017-c8myq6bi 448 32 translation translation NN cord-018017-c8myq6bi 448 33 . . . cord-018017-c8myq6bi 449 1 The the DT cord-018017-c8myq6bi 449 2 design design NN cord-018017-c8myq6bi 449 3 of of IN cord-018017-c8myq6bi 449 4 steric steric NN cord-018017-c8myq6bi 449 5 blocking block VBG cord-018017-c8myq6bi 449 6 RNA RNA NNP cord-018017-c8myq6bi 449 7 - - HYPH cord-018017-c8myq6bi 449 8 based base VBN cord-018017-c8myq6bi 449 9 therapeutics therapeutic NNS cord-018017-c8myq6bi 449 10 involves involve VBZ cord-018017-c8myq6bi 449 11 preventing prevent VBG cord-018017-c8myq6bi 449 12 translation translation NN cord-018017-c8myq6bi 449 13 , , , cord-018017-c8myq6bi 449 14 disrupting disrupt VBG cord-018017-c8myq6bi 449 15 RNA RNA NNP cord-018017-c8myq6bi 449 16 secondary secondary JJ cord-018017-c8myq6bi 449 17 structure structure NN cord-018017-c8myq6bi 449 18 and and CC cord-018017-c8myq6bi 449 19 masking mask VBG cord-018017-c8myq6bi 449 20 recognition recognition NN cord-018017-c8myq6bi 449 21 sites site NNS cord-018017-c8myq6bi 449 22 for for IN cord-018017-c8myq6bi 449 23 RNA RNA NNP cord-018017-c8myq6bi 449 24 dependent dependent JJ cord-018017-c8myq6bi 449 25 RNA RNA NNP cord-018017-c8myq6bi 449 26 polymerase polymerase NN cord-018017-c8myq6bi 449 27 ( ( -LRB- cord-018017-c8myq6bi 449 28 RdRp RdRp NNP cord-018017-c8myq6bi 449 29 ) ) -RRB- cord-018017-c8myq6bi 449 30 . . . cord-018017-c8myq6bi 450 1 The the DT cord-018017-c8myq6bi 450 2 targeting targeting NN cord-018017-c8myq6bi 450 3 of of IN cord-018017-c8myq6bi 450 4 either either CC cord-018017-c8myq6bi 450 5 the the DT cord-018017-c8myq6bi 450 6 5′-terminus 5′-terminus CD cord-018017-c8myq6bi 450 7 and and CC cord-018017-c8myq6bi 450 8 the the DT cord-018017-c8myq6bi 450 9 first first JJ cord-018017-c8myq6bi 450 10 ORF ORF NNP cord-018017-c8myq6bi 450 11 - - HYPH cord-018017-c8myq6bi 450 12 AUG AUG NNP cord-018017-c8myq6bi 450 13 are be VBP cord-018017-c8myq6bi 450 14 active active JJ cord-018017-c8myq6bi 450 15 . . . cord-018017-c8myq6bi 451 1 Further further RB cord-018017-c8myq6bi 451 2 , , , cord-018017-c8myq6bi 451 3 efficacy efficacy NN cord-018017-c8myq6bi 451 4 in in IN cord-018017-c8myq6bi 451 5 animal animal NN cord-018017-c8myq6bi 451 6 challenge challenge NN cord-018017-c8myq6bi 451 7 studies study NNS cord-018017-c8myq6bi 451 8 is be VBZ cord-018017-c8myq6bi 451 9 observed observe VBN cord-018017-c8myq6bi 451 10 with with IN cord-018017-c8myq6bi 451 11 high high JJ cord-018017-c8myq6bi 451 12 fidelity fidelity NN cord-018017-c8myq6bi 451 13 when when WRB cord-018017-c8myq6bi 451 14 the the DT cord-018017-c8myq6bi 451 15 most most RBS cord-018017-c8myq6bi 451 16 effective effective JJ cord-018017-c8myq6bi 451 17 agent agent NN cord-018017-c8myq6bi 451 18 identified identify VBN cord-018017-c8myq6bi 451 19 in in IN cord-018017-c8myq6bi 451 20 vitro vitro FW cord-018017-c8myq6bi 451 21 is be VBZ cord-018017-c8myq6bi 451 22 employed employ VBN cord-018017-c8myq6bi 451 23 . . . cord-018017-c8myq6bi 452 1 The the DT cord-018017-c8myq6bi 452 2 family family NN cord-018017-c8myq6bi 452 3 Astroviridae Astroviridae NNP cord-018017-c8myq6bi 452 4 with with IN cord-018017-c8myq6bi 452 5 six six CD cord-018017-c8myq6bi 452 6 different different JJ cord-018017-c8myq6bi 452 7 human human JJ cord-018017-c8myq6bi 452 8 astroviruses astroviruse NNS cord-018017-c8myq6bi 452 9 ( ( -LRB- cord-018017-c8myq6bi 452 10 HuAstV HuAstV NNP cord-018017-c8myq6bi 452 11 ) ) -RRB- cord-018017-c8myq6bi 452 12 responsible responsible JJ cord-018017-c8myq6bi 452 13 for for IN cord-018017-c8myq6bi 452 14 2 2 CD cord-018017-c8myq6bi 452 15 - - SYM cord-018017-c8myq6bi 452 16 17 17 CD cord-018017-c8myq6bi 452 17 % % NN cord-018017-c8myq6bi 452 18 of of IN cord-018017-c8myq6bi 452 19 all all DT cord-018017-c8myq6bi 452 20 gastroenteritis gastroenteritis NN cord-018017-c8myq6bi 452 21 . . . cord-018017-c8myq6bi 453 1 We -PRON- PRP cord-018017-c8myq6bi 453 2 found find VBD cord-018017-c8myq6bi 453 3 the the DT cord-018017-c8myq6bi 453 4 5′-terminus 5′-terminus CD cord-018017-c8myq6bi 453 5 1 1 CD cord-018017-c8myq6bi 453 6 to to TO cord-018017-c8myq6bi 453 7 be be VB cord-018017-c8myq6bi 453 8 the the DT cord-018017-c8myq6bi 453 9 most most RBS cord-018017-c8myq6bi 453 10 effective effective JJ cord-018017-c8myq6bi 453 11 site site NN cord-018017-c8myq6bi 453 12 to to TO cord-018017-c8myq6bi 453 13 target target VB cord-018017-c8myq6bi 453 14 . . . cord-018017-c8myq6bi 454 1 This this DT cord-018017-c8myq6bi 454 2 was be VBD cord-018017-c8myq6bi 454 3 also also RB cord-018017-c8myq6bi 454 4 the the DT cord-018017-c8myq6bi 454 5 optimal optimal JJ cord-018017-c8myq6bi 454 6 site site NN cord-018017-c8myq6bi 454 7 for for IN cord-018017-c8myq6bi 454 8 Caliciviridae Caliciviridae NNP cord-018017-c8myq6bi 454 9 including include VBG cord-018017-c8myq6bi 454 10 vesivirus vesivirus NNP cord-018017-c8myq6bi 454 11 ( ( -LRB- cord-018017-c8myq6bi 454 12 VeV VeV NNP cord-018017-c8myq6bi 454 13 ; ; : cord-018017-c8myq6bi 454 14 Martin Martin NNP cord-018017-c8myq6bi 454 15 - - HYPH cord-018017-c8myq6bi 454 16 Alonso Alonso NNP cord-018017-c8myq6bi 454 17 et et NNP cord-018017-c8myq6bi 454 18 al al NNP cord-018017-c8myq6bi 454 19 . . NNP cord-018017-c8myq6bi 454 20 2005 2005 CD cord-018017-c8myq6bi 454 21 ; ; : cord-018017-c8myq6bi 454 22 Stein Stein NNP cord-018017-c8myq6bi 454 23 et et NNP cord-018017-c8myq6bi 454 24 al al NNP cord-018017-c8myq6bi 454 25 . . NNP cord-018017-c8myq6bi 454 26 2001 2001 CD cord-018017-c8myq6bi 454 27 ) ) -RRB- cord-018017-c8myq6bi 454 28 , , , cord-018017-c8myq6bi 454 29 Norovirus Norovirus NNP cord-018017-c8myq6bi 454 30 ( ( -LRB- cord-018017-c8myq6bi 454 31 NoV nov NN cord-018017-c8myq6bi 454 32 ; ; : cord-018017-c8myq6bi 454 33 Bok Bok NNP cord-018017-c8myq6bi 454 34 et et NNP cord-018017-c8myq6bi 454 35 al al NNP cord-018017-c8myq6bi 454 36 . . NNP cord-018017-c8myq6bi 454 37 2008 2008 CD cord-018017-c8myq6bi 454 38 ) ) -RRB- cord-018017-c8myq6bi 454 39 , , , cord-018017-c8myq6bi 454 40 and and CC cord-018017-c8myq6bi 454 41 feline feline JJ cord-018017-c8myq6bi 454 42 Calicivirus Calicivirus NNP cord-018017-c8myq6bi 454 43 ( ( -LRB- cord-018017-c8myq6bi 454 44 FCV FCV NNP cord-018017-c8myq6bi 454 45 ; ; : cord-018017-c8myq6bi 454 46 Smith Smith NNP cord-018017-c8myq6bi 454 47 et et NNP cord-018017-c8myq6bi 454 48 al al NNP cord-018017-c8myq6bi 454 49 . . NNP cord-018017-c8myq6bi 454 50 2008 2008 CD cord-018017-c8myq6bi 454 51 ) ) -RRB- cord-018017-c8myq6bi 454 52 ; ; : cord-018017-c8myq6bi 454 53 the the DT cord-018017-c8myq6bi 454 54 Flaviviridae Flaviviridae NNP cord-018017-c8myq6bi 454 55 including include VBG cord-018017-c8myq6bi 454 56 Dengue Dengue NNP cord-018017-c8myq6bi 454 57 ( ( -LRB- cord-018017-c8myq6bi 454 58 DEN DEN NNP cord-018017-c8myq6bi 454 59 ; ; : cord-018017-c8myq6bi 454 60 Kinney Kinney NNP cord-018017-c8myq6bi 454 61 et et NNP cord-018017-c8myq6bi 454 62 al al NNP cord-018017-c8myq6bi 454 63 . . NNP cord-018017-c8myq6bi 454 64 2005 2005 CD cord-018017-c8myq6bi 454 65 ; ; : cord-018017-c8myq6bi 454 66 Holden Holden NNP cord-018017-c8myq6bi 454 67 et et NNP cord-018017-c8myq6bi 454 68 al al NNP cord-018017-c8myq6bi 454 69 . . . cord-018017-c8myq6bi 454 70 2006 2006 CD cord-018017-c8myq6bi 454 71 ) ) -RRB- cord-018017-c8myq6bi 454 72 , , , cord-018017-c8myq6bi 454 73 and and CC cord-018017-c8myq6bi 454 74 West West NNP cord-018017-c8myq6bi 454 75 Nile Nile NNP cord-018017-c8myq6bi 454 76 Virus Virus NNP cord-018017-c8myq6bi 454 77 ( ( -LRB- cord-018017-c8myq6bi 454 78 WNV WNV NNP cord-018017-c8myq6bi 454 79 ; ; : cord-018017-c8myq6bi 454 80 Deas Deas NNP cord-018017-c8myq6bi 454 81 et et NNP cord-018017-c8myq6bi 454 82 al al NNP cord-018017-c8myq6bi 454 83 . . . cord-018017-c8myq6bi 455 1 2007 2007 CD cord-018017-c8myq6bi 455 2 ; ; : cord-018017-c8myq6bi 455 3 Zhang Zhang NNP cord-018017-c8myq6bi 455 4 et et NNP cord-018017-c8myq6bi 455 5 al al NNP cord-018017-c8myq6bi 455 6 . . NNP cord-018017-c8myq6bi 455 7 2008 2008 CD cord-018017-c8myq6bi 455 8 ) ) -RRB- cord-018017-c8myq6bi 455 9 , , . cord-018017-c8myq6bi 456 1 Arteriviridae arteriviridae NN cord-018017-c8myq6bi 456 2 including include VBG cord-018017-c8myq6bi 456 3 agriculturally agriculturally RB cord-018017-c8myq6bi 456 4 important important JJ cord-018017-c8myq6bi 456 5 Equine Equine NNP cord-018017-c8myq6bi 456 6 Arterivirus Arterivirus NNP cord-018017-c8myq6bi 456 7 ( ( -LRB- cord-018017-c8myq6bi 456 8 EAV EAV NNP cord-018017-c8myq6bi 456 9 ; ; : cord-018017-c8myq6bi 456 10 van van NNP cord-018017-c8myq6bi 456 11 den den NNP cord-018017-c8myq6bi 456 12 Born Born NNP cord-018017-c8myq6bi 456 13 et et NNP cord-018017-c8myq6bi 456 14 al al NNP cord-018017-c8myq6bi 456 15 . . NNP cord-018017-c8myq6bi 456 16 2005 2005 CD cord-018017-c8myq6bi 456 17 ) ) -RRB- cord-018017-c8myq6bi 456 18 , , , cord-018017-c8myq6bi 456 19 and and CC cord-018017-c8myq6bi 456 20 porcine porcine JJ cord-018017-c8myq6bi 456 21 respiratory respiratory JJ cord-018017-c8myq6bi 456 22 and and CC cord-018017-c8myq6bi 456 23 reproductive reproductive JJ cord-018017-c8myq6bi 456 24 virus virus NN cord-018017-c8myq6bi 456 25 ( ( -LRB- cord-018017-c8myq6bi 456 26 PRRSV PRRSV NNP cord-018017-c8myq6bi 456 27 ; ; : cord-018017-c8myq6bi 457 1 Zhang Zhang NNP cord-018017-c8myq6bi 457 2 et et NNP cord-018017-c8myq6bi 457 3 al al NNP cord-018017-c8myq6bi 457 4 . . . cord-018017-c8myq6bi 458 1 2006a 2006a CD cord-018017-c8myq6bi 458 2 , , , cord-018017-c8myq6bi 458 3 b b LS cord-018017-c8myq6bi 458 4 ) ) -RRB- cord-018017-c8myq6bi 458 5 ; ; : cord-018017-c8myq6bi 458 6 and and CC cord-018017-c8myq6bi 458 7 the the DT cord-018017-c8myq6bi 458 8 Togaviridae Togaviridae NNP cord-018017-c8myq6bi 458 9 exemplified exemplify VBN cord-018017-c8myq6bi 458 10 by by IN cord-018017-c8myq6bi 458 11 Venezuelan venezuelan JJ cord-018017-c8myq6bi 458 12 Equine Equine NNP cord-018017-c8myq6bi 458 13 Encephalitis Encephalitis NNP cord-018017-c8myq6bi 458 14 Virus virus NN cord-018017-c8myq6bi 458 15 ( ( -LRB- cord-018017-c8myq6bi 458 16 VEEV VEEV NNP cord-018017-c8myq6bi 458 17 ; ; : cord-018017-c8myq6bi 458 18 Paessler Paessler NNP cord-018017-c8myq6bi 458 19 et et NNP cord-018017-c8myq6bi 458 20 al al NNP cord-018017-c8myq6bi 458 21 . . NNP cord-018017-c8myq6bi 458 22 2008 2008 CD cord-018017-c8myq6bi 458 23 ) ) -RRB- cord-018017-c8myq6bi 458 24 . . . cord-018017-c8myq6bi 459 1 The the DT cord-018017-c8myq6bi 459 2 family family NN cord-018017-c8myq6bi 459 3 Coronaviridae Coronaviridae NNP cord-018017-c8myq6bi 459 4 revealed reveal VBD cord-018017-c8myq6bi 459 5 a a DT cord-018017-c8myq6bi 459 6 new new JJ cord-018017-c8myq6bi 459 7 active active JJ cord-018017-c8myq6bi 459 8 target target NN cord-018017-c8myq6bi 459 9 site site NN cord-018017-c8myq6bi 459 10 in in IN cord-018017-c8myq6bi 459 11 the the DT cord-018017-c8myq6bi 459 12 transcription transcription NN cord-018017-c8myq6bi 459 13 regulatory regulatory JJ cord-018017-c8myq6bi 459 14 sequence sequence NN cord-018017-c8myq6bi 459 15 ( ( -LRB- cord-018017-c8myq6bi 459 16 5'-CGAAC-3′ 5'-cgaac-3′ CD cord-018017-c8myq6bi 459 17 ) ) -RRB- cord-018017-c8myq6bi 459 18 in in IN cord-018017-c8myq6bi 459 19 both both DT cord-018017-c8myq6bi 459 20 mouse mouse NN cord-018017-c8myq6bi 459 21 hepatitis hepatitis NN cord-018017-c8myq6bi 459 22 virus virus NN cord-018017-c8myq6bi 459 23 ( ( -LRB- cord-018017-c8myq6bi 459 24 MHV mhv NN cord-018017-c8myq6bi 459 25 ; ; : cord-018017-c8myq6bi 459 26 Neuman Neuman NNP cord-018017-c8myq6bi 459 27 et et NNP cord-018017-c8myq6bi 459 28 al al NNP cord-018017-c8myq6bi 459 29 . . . cord-018017-c8myq6bi 459 30 2004 2004 CD cord-018017-c8myq6bi 459 31 ) ) -RRB- cord-018017-c8myq6bi 459 32 and and CC cord-018017-c8myq6bi 459 33 the the DT cord-018017-c8myq6bi 459 34 Severe severe JJ cord-018017-c8myq6bi 459 35 Acute Acute NNP cord-018017-c8myq6bi 459 36 Respiratory Respiratory NNP cord-018017-c8myq6bi 459 37 Syndrome Syndrome NNP cord-018017-c8myq6bi 459 38 virus virus NN cord-018017-c8myq6bi 459 39 ( ( -LRB- cord-018017-c8myq6bi 459 40 SARS SARS NNP cord-018017-c8myq6bi 459 41 ; ; : cord-018017-c8myq6bi 459 42 Neuman Neuman NNP cord-018017-c8myq6bi 459 43 et et NNP cord-018017-c8myq6bi 459 44 al al NNP cord-018017-c8myq6bi 459 45 . . NNP cord-018017-c8myq6bi 459 46 2005 2005 CD cord-018017-c8myq6bi 459 47 ) ) -RRB- cord-018017-c8myq6bi 459 48 . . . cord-018017-c8myq6bi 460 1 The the DT cord-018017-c8myq6bi 460 2 Picornaviridae Picornaviridae NNP cord-018017-c8myq6bi 460 3 active active JJ cord-018017-c8myq6bi 460 4 target target NN cord-018017-c8myq6bi 460 5 site site NN cord-018017-c8myq6bi 460 6 involved involve VBD cord-018017-c8myq6bi 460 7 a a DT cord-018017-c8myq6bi 460 8 highly highly RB cord-018017-c8myq6bi 460 9 conserved conserve VBN cord-018017-c8myq6bi 460 10 sequence sequence NN cord-018017-c8myq6bi 460 11 in in IN cord-018017-c8myq6bi 460 12 the the DT cord-018017-c8myq6bi 460 13 internal internal JJ cord-018017-c8myq6bi 460 14 ribosomal ribosomal JJ cord-018017-c8myq6bi 460 15 entry entry NN cord-018017-c8myq6bi 460 16 site site NN cord-018017-c8myq6bi 460 17 ( ( -LRB- cord-018017-c8myq6bi 460 18 IRES IRES NNP cord-018017-c8myq6bi 460 19 ) ) -RRB- cord-018017-c8myq6bi 460 20 in in IN cord-018017-c8myq6bi 460 21 polio polio NN cord-018017-c8myq6bi 460 22 virus virus NN cord-018017-c8myq6bi 460 23 ( ( -LRB- cord-018017-c8myq6bi 460 24 PV PV NNP cord-018017-c8myq6bi 460 25 ; ; : cord-018017-c8myq6bi 460 26 Stone Stone NNP cord-018017-c8myq6bi 460 27 et et NNP cord-018017-c8myq6bi 460 28 al al NNP cord-018017-c8myq6bi 460 29 . . NNP cord-018017-c8myq6bi 460 30 2008 2008 CD cord-018017-c8myq6bi 460 31 ) ) -RRB- cord-018017-c8myq6bi 460 32 , , , cord-018017-c8myq6bi 460 33 foot foot NN cord-018017-c8myq6bi 460 34 and and CC cord-018017-c8myq6bi 460 35 mouth mouth NN cord-018017-c8myq6bi 460 36 disease disease NN cord-018017-c8myq6bi 460 37 virus virus NN cord-018017-c8myq6bi 460 38 ( ( -LRB- cord-018017-c8myq6bi 460 39 FMDV FMDV NNP cord-018017-c8myq6bi 460 40 ; ; : cord-018017-c8myq6bi 460 41 Vagnozzi Vagnozzi NNP cord-018017-c8myq6bi 460 42 et et NNP cord-018017-c8myq6bi 460 43 al al NNP cord-018017-c8myq6bi 460 44 . . NNP cord-018017-c8myq6bi 460 45 2007 2007 CD cord-018017-c8myq6bi 460 46 ) ) -RRB- cord-018017-c8myq6bi 460 47 , , , cord-018017-c8myq6bi 460 48 and and CC cord-018017-c8myq6bi 460 49 the the DT cord-018017-c8myq6bi 460 50 coxsackievirus coxsackievirus NNP cord-018017-c8myq6bi 460 51 ( ( -LRB- cord-018017-c8myq6bi 460 52 CVB3 CVB3 NNPS cord-018017-c8myq6bi 460 53 ; ; : cord-018017-c8myq6bi 460 54 Yuan Yuan NNP cord-018017-c8myq6bi 460 55 et et FW cord-018017-c8myq6bi 460 56 al al NNP cord-018017-c8myq6bi 460 57 . . . cord-018017-c8myq6bi 460 58 2006 2006 CD cord-018017-c8myq6bi 460 59 ) ) -RRB- cord-018017-c8myq6bi 460 60 . . . cord-018017-c8myq6bi 461 1 Single Single NNP cord-018017-c8myq6bi 461 2 Stranded Stranded NNP cord-018017-c8myq6bi 461 3 RNA RNA NNP cord-018017-c8myq6bi 461 4 Viruses virus NNS cord-018017-c8myq6bi 461 5 Negative negative JJ cord-018017-c8myq6bi 461 6 Sense sense NN cord-018017-c8myq6bi 461 7 ( ( -LRB- cord-018017-c8myq6bi 461 8 ssRNA(− ssrna(− NN cord-018017-c8myq6bi 461 9 ) ) -RRB- cord-018017-c8myq6bi 461 10 ) ) -RRB- cord-018017-c8myq6bi 462 1 These these DT cord-018017-c8myq6bi 462 2 viruses virus NNS cord-018017-c8myq6bi 462 3 are be VBP cord-018017-c8myq6bi 462 4 generally generally RB cord-018017-c8myq6bi 462 5 more more RBR cord-018017-c8myq6bi 462 6 complex complex JJ cord-018017-c8myq6bi 462 7 with with IN cord-018017-c8myq6bi 462 8 respect respect NN cord-018017-c8myq6bi 462 9 to to IN cord-018017-c8myq6bi 462 10 genome genome NN cord-018017-c8myq6bi 462 11 size size NN cord-018017-c8myq6bi 462 12 , , , cord-018017-c8myq6bi 462 13 number number NN cord-018017-c8myq6bi 462 14 of of IN cord-018017-c8myq6bi 462 15 potential potential JJ cord-018017-c8myq6bi 462 16 translated translate VBN cord-018017-c8myq6bi 462 17 viral viral JJ cord-018017-c8myq6bi 462 18 proteins protein NNS cord-018017-c8myq6bi 462 19 , , , cord-018017-c8myq6bi 462 20 and and CC cord-018017-c8myq6bi 462 21 multiple multiple JJ cord-018017-c8myq6bi 462 22 genome genome NN cord-018017-c8myq6bi 462 23 segments segment NNS cord-018017-c8myq6bi 462 24 . . . cord-018017-c8myq6bi 463 1 The the DT cord-018017-c8myq6bi 463 2 genome genome NN cord-018017-c8myq6bi 463 3 must must MD cord-018017-c8myq6bi 463 4 be be VB cord-018017-c8myq6bi 463 5 replicated replicate VBN cord-018017-c8myq6bi 463 6 prior prior RB cord-018017-c8myq6bi 463 7 to to IN cord-018017-c8myq6bi 463 8 translation translation NN cord-018017-c8myq6bi 463 9 of of IN cord-018017-c8myq6bi 463 10 viral viral JJ cord-018017-c8myq6bi 463 11 proteins protein NNS cord-018017-c8myq6bi 463 12 . . . cord-018017-c8myq6bi 464 1 The the DT cord-018017-c8myq6bi 464 2 design design NN cord-018017-c8myq6bi 464 3 of of IN cord-018017-c8myq6bi 464 4 steric steric NN cord-018017-c8myq6bi 464 5 blocking block VBG cord-018017-c8myq6bi 464 6 RNA RNA NNP cord-018017-c8myq6bi 464 7 - - HYPH cord-018017-c8myq6bi 464 8 based base VBN cord-018017-c8myq6bi 464 9 therapeutics therapeutic NNS cord-018017-c8myq6bi 464 10 is be VBZ cord-018017-c8myq6bi 464 11 similar similar JJ cord-018017-c8myq6bi 464 12 to to IN cord-018017-c8myq6bi 464 13 the the DT cord-018017-c8myq6bi 464 14 positive positive JJ cord-018017-c8myq6bi 464 15 sense sense NN cord-018017-c8myq6bi 464 16 RNA RNA NNP cord-018017-c8myq6bi 464 17 genomes genome NNS cord-018017-c8myq6bi 464 18 in in IN cord-018017-c8myq6bi 464 19 that that DT cord-018017-c8myq6bi 464 20 targets target NNS cord-018017-c8myq6bi 464 21 involve involve VBP cord-018017-c8myq6bi 464 22 preventing prevent VBG cord-018017-c8myq6bi 464 23 translation translation NN cord-018017-c8myq6bi 464 24 and and CC cord-018017-c8myq6bi 464 25 masking mask VBG cord-018017-c8myq6bi 464 26 recognition recognition NN cord-018017-c8myq6bi 464 27 sites site NNS cord-018017-c8myq6bi 464 28 for for IN cord-018017-c8myq6bi 464 29 RNA RNA NNP cord-018017-c8myq6bi 464 30 dependent dependent JJ cord-018017-c8myq6bi 464 31 RNA RNA NNP cord-018017-c8myq6bi 464 32 polymerase polymerase NN cord-018017-c8myq6bi 464 33 ( ( -LRB- cord-018017-c8myq6bi 464 34 RdRp RdRp NNP cord-018017-c8myq6bi 464 35 ) ) -RRB- cord-018017-c8myq6bi 464 36 . . . cord-018017-c8myq6bi 465 1 We -PRON- PRP cord-018017-c8myq6bi 465 2 investigated investigate VBD cord-018017-c8myq6bi 465 3 11 11 CD cord-018017-c8myq6bi 465 4 different different JJ cord-018017-c8myq6bi 465 5 targets target NNS cord-018017-c8myq6bi 465 6 in in IN cord-018017-c8myq6bi 465 7 measles measles NNP cord-018017-c8myq6bi 465 8 virus virus NN cord-018017-c8myq6bi 465 9 ( ( -LRB- cord-018017-c8myq6bi 465 10 MeV MeV NNP cord-018017-c8myq6bi 465 11 ) ) -RRB- cord-018017-c8myq6bi 465 12 , , , cord-018017-c8myq6bi 465 13 a a DT cord-018017-c8myq6bi 465 14 member member NN cord-018017-c8myq6bi 465 15 of of IN cord-018017-c8myq6bi 465 16 the the DT cord-018017-c8myq6bi 465 17 Paramyxoviridae Paramyxoviridae NNP cord-018017-c8myq6bi 465 18 , , , cord-018017-c8myq6bi 465 19 finding find VBG cord-018017-c8myq6bi 465 20 the the DT cord-018017-c8myq6bi 465 21 translation translation NN cord-018017-c8myq6bi 465 22 initiation initiation NN cord-018017-c8myq6bi 465 23 start start VB cord-018017-c8myq6bi 465 24 site site NN cord-018017-c8myq6bi 465 25 of of IN cord-018017-c8myq6bi 465 26 N n NN cord-018017-c8myq6bi 465 27 the the DT cord-018017-c8myq6bi 465 28 optimal optimal JJ cord-018017-c8myq6bi 465 29 target target NN cord-018017-c8myq6bi 465 30 ( ( -LRB- cord-018017-c8myq6bi 465 31 Sleeman Sleeman NNP cord-018017-c8myq6bi 465 32 et et FW cord-018017-c8myq6bi 465 33 al al NNP cord-018017-c8myq6bi 465 34 . . NNP cord-018017-c8myq6bi 465 35 2009 2009 CD cord-018017-c8myq6bi 465 36 ) ) -RRB- cord-018017-c8myq6bi 465 37 . . . cord-018017-c8myq6bi 466 1 Studies study NNS cord-018017-c8myq6bi 466 2 with with IN cord-018017-c8myq6bi 466 3 the the DT cord-018017-c8myq6bi 466 4 human human JJ cord-018017-c8myq6bi 466 5 respiratory respiratory JJ cord-018017-c8myq6bi 466 6 syncytial syncytial JJ cord-018017-c8myq6bi 466 7 virus virus NN cord-018017-c8myq6bi 466 8 ( ( -LRB- cord-018017-c8myq6bi 466 9 hRSV hRSV NNP cord-018017-c8myq6bi 466 10 ) ) -RRB- cord-018017-c8myq6bi 466 11 found find VBD cord-018017-c8myq6bi 466 12 the the DT cord-018017-c8myq6bi 466 13 translation translation NN cord-018017-c8myq6bi 466 14 site site NN cord-018017-c8myq6bi 466 15 for for IN cord-018017-c8myq6bi 466 16 L L NNP cord-018017-c8myq6bi 466 17 to to TO cord-018017-c8myq6bi 466 18 be be VB cord-018017-c8myq6bi 466 19 most most RBS cord-018017-c8myq6bi 466 20 active active JJ cord-018017-c8myq6bi 467 1 ( ( -LRB- cord-018017-c8myq6bi 467 2 Lai Lai NNP cord-018017-c8myq6bi 467 3 et et FW cord-018017-c8myq6bi 467 4 al al NNP cord-018017-c8myq6bi 467 5 . . NNP cord-018017-c8myq6bi 467 6 2008 2008 CD cord-018017-c8myq6bi 467 7 ) ) -RRB- cord-018017-c8myq6bi 467 8 . . . cord-018017-c8myq6bi 468 1 The the DT cord-018017-c8myq6bi 468 2 Orthomyxoviridae Orthomyxoviridae NNP cord-018017-c8myq6bi 468 3 studies study NNS cord-018017-c8myq6bi 468 4 investigated investigate VBD cord-018017-c8myq6bi 468 5 influenza influenza NN cord-018017-c8myq6bi 468 6 A a DT cord-018017-c8myq6bi 468 7 virus virus NN cord-018017-c8myq6bi 468 8 probing probe VBG cord-018017-c8myq6bi 468 9 each each DT cord-018017-c8myq6bi 468 10 of of IN cord-018017-c8myq6bi 468 11 the the DT cord-018017-c8myq6bi 468 12 8 8 CD cord-018017-c8myq6bi 468 13 viral viral JJ cord-018017-c8myq6bi 468 14 segments segment NNS cord-018017-c8myq6bi 468 15 finding find VBG cord-018017-c8myq6bi 468 16 translation translation NN cord-018017-c8myq6bi 468 17 of of IN cord-018017-c8myq6bi 468 18 PB1 pb1 NN cord-018017-c8myq6bi 468 19 active active JJ cord-018017-c8myq6bi 468 20 as as RB cord-018017-c8myq6bi 468 21 well well RB cord-018017-c8myq6bi 468 22 as as IN cord-018017-c8myq6bi 468 23 the the DT cord-018017-c8myq6bi 468 24 5'terminal 5'terminal CD cord-018017-c8myq6bi 468 25 of of IN cord-018017-c8myq6bi 468 26 vNP vnp NN cord-018017-c8myq6bi 468 27 for for IN cord-018017-c8myq6bi 468 28 H3N2 H3N2 NNP cord-018017-c8myq6bi 468 29 ( ( -LRB- cord-018017-c8myq6bi 468 30 Ge Ge NNP cord-018017-c8myq6bi 468 31 et et NNP cord-018017-c8myq6bi 468 32 al al NNP cord-018017-c8myq6bi 468 33 . . . cord-018017-c8myq6bi 468 34 2006 2006 CD cord-018017-c8myq6bi 468 35 ) ) -RRB- cord-018017-c8myq6bi 468 36 and and CC cord-018017-c8myq6bi 468 37 H3N8 H3N8 NNP cord-018017-c8myq6bi 468 38 ( ( -LRB- cord-018017-c8myq6bi 468 39 Lupfer Lupfer NNP cord-018017-c8myq6bi 468 40 et et FW cord-018017-c8myq6bi 468 41 al al NNP cord-018017-c8myq6bi 468 42 . . NNP cord-018017-c8myq6bi 468 43 2008 2008 CD cord-018017-c8myq6bi 468 44 ) ) -RRB- cord-018017-c8myq6bi 469 1 but but CC cord-018017-c8myq6bi 469 2 a a DT cord-018017-c8myq6bi 469 3 combination combination NN cord-018017-c8myq6bi 469 4 of of IN cord-018017-c8myq6bi 469 5 targets target NNS cord-018017-c8myq6bi 469 6 was be VBD cord-018017-c8myq6bi 469 7 required require VBN cord-018017-c8myq6bi 469 8 in in IN cord-018017-c8myq6bi 469 9 animal animal NN cord-018017-c8myq6bi 469 10 studies study NNS cord-018017-c8myq6bi 469 11 with with IN cord-018017-c8myq6bi 469 12 a a DT cord-018017-c8myq6bi 469 13 high high JJ cord-018017-c8myq6bi 469 14 pathogenic pathogenic JJ cord-018017-c8myq6bi 469 15 viral viral JJ cord-018017-c8myq6bi 469 16 H7N7 H7N7 NNP cord-018017-c8myq6bi 469 17 isolate isolate NN cord-018017-c8myq6bi 469 18 ( ( -LRB- cord-018017-c8myq6bi 469 19 Gabriel Gabriel NNP cord-018017-c8myq6bi 469 20 et et NNP cord-018017-c8myq6bi 469 21 al al NNP cord-018017-c8myq6bi 469 22 . . NNP cord-018017-c8myq6bi 469 23 2008 2008 CD cord-018017-c8myq6bi 469 24 ) ) -RRB- cord-018017-c8myq6bi 469 25 . . . cord-018017-c8myq6bi 470 1 More more RBR cord-018017-c8myq6bi 470 2 extensive extensive JJ cord-018017-c8myq6bi 470 3 influenza influenza NN cord-018017-c8myq6bi 470 4 A a DT cord-018017-c8myq6bi 470 5 studies study NNS cord-018017-c8myq6bi 470 6 revealed reveal VBD cord-018017-c8myq6bi 470 7 a a DT cord-018017-c8myq6bi 470 8 new new JJ cord-018017-c8myq6bi 470 9 target target NN cord-018017-c8myq6bi 470 10 , , , cord-018017-c8myq6bi 470 11 the the DT cord-018017-c8myq6bi 470 12 M M NNP cord-018017-c8myq6bi 470 13 - - HYPH cord-018017-c8myq6bi 470 14 segment segment NN cord-018017-c8myq6bi 470 15 splice splice NN cord-018017-c8myq6bi 470 16 donor donor NN cord-018017-c8myq6bi 470 17 site site NN cord-018017-c8myq6bi 470 18 . . . cord-018017-c8myq6bi 471 1 This this DT cord-018017-c8myq6bi 471 2 target target NN cord-018017-c8myq6bi 471 3 was be VBD cord-018017-c8myq6bi 471 4 evaluated evaluate VBN cord-018017-c8myq6bi 471 5 in in IN cord-018017-c8myq6bi 471 6 phase phase NN cord-018017-c8myq6bi 471 7 I -PRON- PRP cord-018017-c8myq6bi 471 8 clinical clinical JJ cord-018017-c8myq6bi 471 9 trials trial NNS cord-018017-c8myq6bi 471 10 . . . cord-018017-c8myq6bi 472 1 The the DT cord-018017-c8myq6bi 472 2 antisense antisense NN cord-018017-c8myq6bi 472 3 platform platform NN cord-018017-c8myq6bi 472 4 technology technology NN cord-018017-c8myq6bi 472 5 has have VBZ cord-018017-c8myq6bi 472 6 limitations limitation NNS cord-018017-c8myq6bi 472 7 in in IN cord-018017-c8myq6bi 472 8 targeting target VBG cord-018017-c8myq6bi 472 9 viral viral JJ cord-018017-c8myq6bi 472 10 sequences sequence NNS cord-018017-c8myq6bi 472 11 . . . cord-018017-c8myq6bi 473 1 Inhibiting inhibit VBG cord-018017-c8myq6bi 473 2 virally virally RB cord-018017-c8myq6bi 473 3 encoded encode VBN cord-018017-c8myq6bi 473 4 proteins protein NNS cord-018017-c8myq6bi 473 5 or or CC cord-018017-c8myq6bi 473 6 blocking block VBG cord-018017-c8myq6bi 473 7 viral viral JJ cord-018017-c8myq6bi 473 8 replication replication NN cord-018017-c8myq6bi 473 9 by by IN cord-018017-c8myq6bi 473 10 interfering interfere VBG cord-018017-c8myq6bi 473 11 with with IN cord-018017-c8myq6bi 473 12 the the DT cord-018017-c8myq6bi 473 13 polymerase polymerase NN cord-018017-c8myq6bi 473 14 does do VBZ cord-018017-c8myq6bi 473 15 not not RB cord-018017-c8myq6bi 473 16 always always RB cord-018017-c8myq6bi 473 17 work work VB cord-018017-c8myq6bi 473 18 . . . cord-018017-c8myq6bi 474 1 The the DT cord-018017-c8myq6bi 474 2 Arenaviridae Arenaviridae NNP cord-018017-c8myq6bi 474 3 family family NN cord-018017-c8myq6bi 474 4 proved prove VBD cord-018017-c8myq6bi 474 5 difficult difficult JJ cord-018017-c8myq6bi 474 6 . . . cord-018017-c8myq6bi 475 1 We -PRON- PRP cord-018017-c8myq6bi 475 2 experienced experience VBD cord-018017-c8myq6bi 475 3 some some DT cord-018017-c8myq6bi 475 4 success success NN cord-018017-c8myq6bi 475 5 with with IN cord-018017-c8myq6bi 475 6 Junin Junin NNP cord-018017-c8myq6bi 475 7 and and CC cord-018017-c8myq6bi 475 8 Lymphochoriomeningitis Lymphochoriomeningitis NNP cord-018017-c8myq6bi 475 9 virus virus NN cord-018017-c8myq6bi 475 10 ( ( -LRB- cord-018017-c8myq6bi 475 11 LCMV LCMV NNP cord-018017-c8myq6bi 475 12 ) ) -RRB- cord-018017-c8myq6bi 475 13 in in IN cord-018017-c8myq6bi 475 14 cell cell NN cord-018017-c8myq6bi 475 15 culture culture NN cord-018017-c8myq6bi 475 16 observing observe VBG cord-018017-c8myq6bi 475 17 4 4 CD cord-018017-c8myq6bi 475 18 log log VB cord-018017-c8myq6bi 475 19 10 10 CD cord-018017-c8myq6bi 475 20 reductions reduction NNS cord-018017-c8myq6bi 475 21 in in IN cord-018017-c8myq6bi 475 22 viral viral JJ cord-018017-c8myq6bi 475 23 titer titer NN cord-018017-c8myq6bi 475 24 with with IN cord-018017-c8myq6bi 475 25 a a DT cord-018017-c8myq6bi 475 26 PMO PMO NNP cord-018017-c8myq6bi 475 27 targeting target VBG cord-018017-c8myq6bi 475 28 the the DT cord-018017-c8myq6bi 475 29 highly highly RB cord-018017-c8myq6bi 475 30 conserved conserved JJ cord-018017-c8myq6bi 475 31 viral viral JJ cord-018017-c8myq6bi 475 32 genome genome NN cord-018017-c8myq6bi 475 33 terminus terminus NN cord-018017-c8myq6bi 475 34 . . . cord-018017-c8myq6bi 476 1 However however RB cord-018017-c8myq6bi 476 2 , , , cord-018017-c8myq6bi 476 3 we -PRON- PRP cord-018017-c8myq6bi 476 4 failed fail VBD cord-018017-c8myq6bi 476 5 to to TO cord-018017-c8myq6bi 476 6 provide provide VB cord-018017-c8myq6bi 476 7 survival survival NN cord-018017-c8myq6bi 476 8 benefit benefit NN cord-018017-c8myq6bi 476 9 to to IN cord-018017-c8myq6bi 476 10 guinea guinea NN cord-018017-c8myq6bi 476 11 pigs pig NNS cord-018017-c8myq6bi 476 12 challenged challenge VBN cord-018017-c8myq6bi 476 13 with with IN cord-018017-c8myq6bi 476 14 either either CC cord-018017-c8myq6bi 476 15 Junin Junin NNP cord-018017-c8myq6bi 476 16 or or CC cord-018017-c8myq6bi 476 17 Lassa Lassa NNP cord-018017-c8myq6bi 476 18 virus virus NN cord-018017-c8myq6bi 476 19 . . . cord-018017-c8myq6bi 477 1 We -PRON- PRP cord-018017-c8myq6bi 477 2 then then RB cord-018017-c8myq6bi 477 3 tried try VBD cord-018017-c8myq6bi 477 4 the the DT cord-018017-c8myq6bi 477 5 mouse mouse NN cord-018017-c8myq6bi 477 6 challenged challenge VBN cord-018017-c8myq6bi 477 7 with with IN cord-018017-c8myq6bi 477 8 LCMV LCMV NNP cord-018017-c8myq6bi 477 9 and and CC cord-018017-c8myq6bi 477 10 failed fail VBD cord-018017-c8myq6bi 477 11 again again RB cord-018017-c8myq6bi 478 1 but but CC cord-018017-c8myq6bi 478 2 we -PRON- PRP cord-018017-c8myq6bi 478 3 observed observe VBD cord-018017-c8myq6bi 478 4 hemorrhagic hemorrhagic JJ cord-018017-c8myq6bi 478 5 disease disease NN cord-018017-c8myq6bi 478 6 in in IN cord-018017-c8myq6bi 478 7 the the DT cord-018017-c8myq6bi 478 8 mouse mouse NN cord-018017-c8myq6bi 478 9 , , , cord-018017-c8myq6bi 478 10 a a DT cord-018017-c8myq6bi 478 11 severe severe JJ cord-018017-c8myq6bi 478 12 consequence consequence NN cord-018017-c8myq6bi 478 13 of of IN cord-018017-c8myq6bi 478 14 infection infection NN cord-018017-c8myq6bi 478 15 that that WDT cord-018017-c8myq6bi 478 16 mimics mimic VBZ cord-018017-c8myq6bi 478 17 the the DT cord-018017-c8myq6bi 478 18 worst bad JJS cord-018017-c8myq6bi 478 19 aspects aspect NNS cord-018017-c8myq6bi 478 20 of of IN cord-018017-c8myq6bi 478 21 arenaviral arenaviral JJ cord-018017-c8myq6bi 478 22 infection infection NN cord-018017-c8myq6bi 478 23 . . . cord-018017-c8myq6bi 479 1 We -PRON- PRP cord-018017-c8myq6bi 479 2 decided decide VBD cord-018017-c8myq6bi 479 3 to to TO cord-018017-c8myq6bi 479 4 try try VB cord-018017-c8myq6bi 479 5 targeting target VBG cord-018017-c8myq6bi 479 6 host host NN cord-018017-c8myq6bi 479 7 genes gene NNS cord-018017-c8myq6bi 479 8 to to TO cord-018017-c8myq6bi 479 9 mitigate mitigate VB cord-018017-c8myq6bi 479 10 disease disease NN cord-018017-c8myq6bi 479 11 in in IN cord-018017-c8myq6bi 479 12 the the DT cord-018017-c8myq6bi 479 13 mouse mouse NN cord-018017-c8myq6bi 479 14 and and CC cord-018017-c8myq6bi 479 15 found find VBD cord-018017-c8myq6bi 479 16 targeting target VBG cord-018017-c8myq6bi 479 17 IL-17 IL-17 NNP cord-018017-c8myq6bi 479 18 provided provide VBD cord-018017-c8myq6bi 479 19 a a DT cord-018017-c8myq6bi 479 20 survival survival NN cord-018017-c8myq6bi 479 21 benefit benefit NN cord-018017-c8myq6bi 479 22 ( ( -LRB- cord-018017-c8myq6bi 479 23 Schnell Schnell NNP cord-018017-c8myq6bi 479 24 et et NNP cord-018017-c8myq6bi 479 25 al al NNP cord-018017-c8myq6bi 479 26 . . NNP cord-018017-c8myq6bi 479 27 2012 2012 CD cord-018017-c8myq6bi 479 28 ) ) -RRB- cord-018017-c8myq6bi 479 29 . . . cord-018017-c8myq6bi 480 1 The the DT cord-018017-c8myq6bi 480 2 success success NN cord-018017-c8myq6bi 480 3 in in IN cord-018017-c8myq6bi 480 4 the the DT cord-018017-c8myq6bi 480 5 face face NN cord-018017-c8myq6bi 480 6 of of IN cord-018017-c8myq6bi 480 7 failure failure NN cord-018017-c8myq6bi 480 8 puts put VBZ cord-018017-c8myq6bi 480 9 targeting target VBG cord-018017-c8myq6bi 480 10 host host NN cord-018017-c8myq6bi 480 11 genes gene NNS cord-018017-c8myq6bi 480 12 at at IN cord-018017-c8myq6bi 480 13 the the DT cord-018017-c8myq6bi 480 14 center center NN cord-018017-c8myq6bi 480 15 of of IN cord-018017-c8myq6bi 480 16 attention attention NN cord-018017-c8myq6bi 480 17 for for IN cord-018017-c8myq6bi 480 18 dealing deal VBG cord-018017-c8myq6bi 480 19 with with IN cord-018017-c8myq6bi 480 20 emerging emerge VBG cord-018017-c8myq6bi 480 21 infectious infectious JJ cord-018017-c8myq6bi 480 22 diseases disease NNS cord-018017-c8myq6bi 480 23 . . . cord-018017-c8myq6bi 481 1 The the DT cord-018017-c8myq6bi 481 2 antisense antisense NN cord-018017-c8myq6bi 481 3 platform platform NN cord-018017-c8myq6bi 481 4 technology technology NN cord-018017-c8myq6bi 481 5 represents represent VBZ cord-018017-c8myq6bi 481 6 an an DT cord-018017-c8myq6bi 481 7 excellent excellent JJ cord-018017-c8myq6bi 481 8 approach approach NN cord-018017-c8myq6bi 481 9 to to IN cord-018017-c8myq6bi 481 10 rapid rapid JJ cord-018017-c8myq6bi 481 11 drug drug NN cord-018017-c8myq6bi 481 12 discovery discovery NN cord-018017-c8myq6bi 481 13 for for IN cord-018017-c8myq6bi 481 14 emerging emerge VBG cord-018017-c8myq6bi 481 15 infectious infectious JJ cord-018017-c8myq6bi 481 16 disease disease NN cord-018017-c8myq6bi 481 17 . . . cord-018017-c8myq6bi 482 1 Rapid rapid JJ cord-018017-c8myq6bi 482 2 discovery discovery NN cord-018017-c8myq6bi 482 3 demonstrated demonstrate VBD cord-018017-c8myq6bi 482 4 repeatedly repeatedly RB cord-018017-c8myq6bi 482 5 but but CC cord-018017-c8myq6bi 482 6 of of IN cord-018017-c8myq6bi 482 7 course course NN cord-018017-c8myq6bi 482 8 , , , cord-018017-c8myq6bi 482 9 the the DT cord-018017-c8myq6bi 482 10 cost cost NN cord-018017-c8myq6bi 482 11 of of IN cord-018017-c8myq6bi 482 12 advanced advanced JJ cord-018017-c8myq6bi 482 13 development development NN cord-018017-c8myq6bi 482 14 is be VBZ cord-018017-c8myq6bi 482 15 daunting daunt VBG cord-018017-c8myq6bi 482 16 . . . cord-018017-c8myq6bi 483 1 The the DT cord-018017-c8myq6bi 483 2 application application NN cord-018017-c8myq6bi 483 3 is be VBZ cord-018017-c8myq6bi 483 4 best good JJS cord-018017-c8myq6bi 483 5 for for IN cord-018017-c8myq6bi 483 6 immediate immediate JJ cord-018017-c8myq6bi 483 7 treatment treatment NN cord-018017-c8myq6bi 483 8 of of IN cord-018017-c8myq6bi 483 9 index index NN cord-018017-c8myq6bi 483 10 cases case NNS cord-018017-c8myq6bi 483 11 , , , cord-018017-c8myq6bi 483 12 close close JJ cord-018017-c8myq6bi 483 13 contacts contact NNS cord-018017-c8myq6bi 483 14 , , , cord-018017-c8myq6bi 483 15 and and CC cord-018017-c8myq6bi 483 16 healthcare healthcare NN cord-018017-c8myq6bi 483 17 workers worker NNS cord-018017-c8myq6bi 483 18 . . . cord-018017-c8myq6bi 484 1 We -PRON- PRP cord-018017-c8myq6bi 484 2 have have VBP cord-018017-c8myq6bi 484 3 an an DT cord-018017-c8myq6bi 484 4 800-pound 800-pound CD cord-018017-c8myq6bi 484 5 gorilla gorilla NN cord-018017-c8myq6bi 484 6 in in IN cord-018017-c8myq6bi 484 7 the the DT cord-018017-c8myq6bi 484 8 room room NN cord-018017-c8myq6bi 484 9 and and CC cord-018017-c8myq6bi 484 10 everyone everyone NN cord-018017-c8myq6bi 484 11 in in IN cord-018017-c8myq6bi 484 12 the the DT cord-018017-c8myq6bi 484 13 room room NN cord-018017-c8myq6bi 484 14 considers consider VBZ cord-018017-c8myq6bi 484 15 it -PRON- PRP cord-018017-c8myq6bi 484 16 someone someone NN cord-018017-c8myq6bi 484 17 else else RB cord-018017-c8myq6bi 484 18 's 's POS cord-018017-c8myq6bi 484 19 problem problem NN cord-018017-c8myq6bi 484 20 . . . cord-018017-c8myq6bi 485 1 The the DT cord-018017-c8myq6bi 485 2 current current JJ cord-018017-c8myq6bi 485 3 course course NN cord-018017-c8myq6bi 485 4 is be VBZ cord-018017-c8myq6bi 485 5 to to TO cord-018017-c8myq6bi 485 6 ignore ignore VB cord-018017-c8myq6bi 485 7 the the DT cord-018017-c8myq6bi 485 8 majestic majestic JJ cord-018017-c8myq6bi 485 9 creature creature NN cord-018017-c8myq6bi 485 10 until until IN cord-018017-c8myq6bi 485 11 it -PRON- PRP cord-018017-c8myq6bi 485 12 starts start VBZ cord-018017-c8myq6bi 485 13 tearing tear VBG cord-018017-c8myq6bi 485 14 limbs limb NNS cord-018017-c8myq6bi 485 15 from from IN cord-018017-c8myq6bi 485 16 people people NNS cord-018017-c8myq6bi 485 17 and and CC cord-018017-c8myq6bi 485 18 then then RB cord-018017-c8myq6bi 485 19 the the DT cord-018017-c8myq6bi 485 20 consensus consensus NN cord-018017-c8myq6bi 485 21 is be VBZ cord-018017-c8myq6bi 485 22 to to TO cord-018017-c8myq6bi 485 23 kill kill VB cord-018017-c8myq6bi 485 24 the the DT cord-018017-c8myq6bi 485 25 gorilla gorilla NN cord-018017-c8myq6bi 485 26 . . . cord-018017-c8myq6bi 486 1 Agencies agency NNS cord-018017-c8myq6bi 486 2 like like IN cord-018017-c8myq6bi 486 3 the the DT cord-018017-c8myq6bi 486 4 World World NNP cord-018017-c8myq6bi 486 5 Health Health NNP cord-018017-c8myq6bi 486 6 Organization Organization NNP cord-018017-c8myq6bi 486 7 ( ( -LRB- cord-018017-c8myq6bi 486 8 WHO who WP cord-018017-c8myq6bi 486 9 ) ) -RRB- cord-018017-c8myq6bi 486 10 , , , cord-018017-c8myq6bi 486 11 the the DT cord-018017-c8myq6bi 486 12 Centers Centers NNPS cord-018017-c8myq6bi 486 13 for for IN cord-018017-c8myq6bi 486 14 Disease Disease NNP cord-018017-c8myq6bi 486 15 Control Control NNP cord-018017-c8myq6bi 486 16 ( ( -LRB- cord-018017-c8myq6bi 486 17 CDC CDC NNP cord-018017-c8myq6bi 486 18 ) ) -RRB- cord-018017-c8myq6bi 486 19 and and CC cord-018017-c8myq6bi 486 20 the the DT cord-018017-c8myq6bi 486 21 National National NNP cord-018017-c8myq6bi 486 22 Institutes Institutes NNPS cord-018017-c8myq6bi 486 23 of of IN cord-018017-c8myq6bi 486 24 Health Health NNP cord-018017-c8myq6bi 486 25 ( ( -LRB- cord-018017-c8myq6bi 486 26 NIH NIH NNP cord-018017-c8myq6bi 486 27 ) ) -RRB- cord-018017-c8myq6bi 486 28 can can MD cord-018017-c8myq6bi 486 29 assemble assemble VB cord-018017-c8myq6bi 486 30 highly highly RB cord-018017-c8myq6bi 486 31 skilled skilled JJ cord-018017-c8myq6bi 486 32 personnel personnel NNS cord-018017-c8myq6bi 486 33 and and CC cord-018017-c8myq6bi 486 34 can can MD cord-018017-c8myq6bi 486 35 confer confer VB cord-018017-c8myq6bi 486 36 with with IN cord-018017-c8myq6bi 486 37 some some DT cord-018017-c8myq6bi 486 38 of of IN cord-018017-c8myq6bi 486 39 the the DT cord-018017-c8myq6bi 486 40 greatest great JJS cord-018017-c8myq6bi 486 41 minds mind NNS cord-018017-c8myq6bi 486 42 in in IN cord-018017-c8myq6bi 486 43 the the DT cord-018017-c8myq6bi 486 44 world world NN cord-018017-c8myq6bi 486 45 . . . cord-018017-c8myq6bi 487 1 Unfortunately unfortunately RB cord-018017-c8myq6bi 487 2 , , , cord-018017-c8myq6bi 487 3 they -PRON- PRP cord-018017-c8myq6bi 487 4 are be VBP cord-018017-c8myq6bi 487 5 all all RB cord-018017-c8myq6bi 487 6 aware aware JJ cord-018017-c8myq6bi 487 7 of of IN cord-018017-c8myq6bi 487 8 the the DT cord-018017-c8myq6bi 487 9 potential potential JJ cord-018017-c8myq6bi 487 10 problem problem NN cord-018017-c8myq6bi 487 11 that that IN cord-018017-c8myq6bi 487 12 an an DT cord-018017-c8myq6bi 487 13 emerging emerge VBG cord-018017-c8myq6bi 487 14 pandemic pandemic NN cord-018017-c8myq6bi 487 15 is be VBZ cord-018017-c8myq6bi 487 16 likely likely JJ cord-018017-c8myq6bi 487 17 to to TO cord-018017-c8myq6bi 487 18 take take VB cord-018017-c8myq6bi 487 19 us -PRON- PRP cord-018017-c8myq6bi 487 20 by by IN cord-018017-c8myq6bi 487 21 surprise surprise NN cord-018017-c8myq6bi 487 22 . . . cord-018017-c8myq6bi 488 1 Significant significant JJ cord-018017-c8myq6bi 488 2 speculation speculation NN cord-018017-c8myq6bi 488 3 that that IN cord-018017-c8myq6bi 488 4 a a DT cord-018017-c8myq6bi 488 5 single single RB cord-018017-c8myq6bi 488 6 - - HYPH cord-018017-c8myq6bi 488 7 stranded strand VBN cord-018017-c8myq6bi 488 8 RNA RNA NNP cord-018017-c8myq6bi 488 9 virus virus NN cord-018017-c8myq6bi 488 10 will will MD cord-018017-c8myq6bi 488 11 emerge emerge VB cord-018017-c8myq6bi 488 12 killing kill VBG cord-018017-c8myq6bi 488 13 tens ten NNS cord-018017-c8myq6bi 488 14 of of IN cord-018017-c8myq6bi 488 15 million million CD cord-018017-c8myq6bi 488 16 people people NNS cord-018017-c8myq6bi 488 17 , , , cord-018017-c8myq6bi 488 18 costing cost VBG cord-018017-c8myq6bi 488 19 hundreds hundred NNS cord-018017-c8myq6bi 488 20 of of IN cord-018017-c8myq6bi 488 21 billions billion NNS cord-018017-c8myq6bi 488 22 of of IN cord-018017-c8myq6bi 488 23 dollars dollar NNS cord-018017-c8myq6bi 488 24 , , , cord-018017-c8myq6bi 488 25 and and CC cord-018017-c8myq6bi 488 26 changing change VBG cord-018017-c8myq6bi 488 27 the the DT cord-018017-c8myq6bi 488 28 course course NN cord-018017-c8myq6bi 488 29 of of IN cord-018017-c8myq6bi 488 30 human human JJ cord-018017-c8myq6bi 488 31 history history NN cord-018017-c8myq6bi 488 32 . . . cord-018017-c8myq6bi 489 1 There there EX cord-018017-c8myq6bi 489 2 is be VBZ cord-018017-c8myq6bi 489 3 a a DT cord-018017-c8myq6bi 489 4 high high JJ cord-018017-c8myq6bi 489 5 probability probability NN cord-018017-c8myq6bi 489 6 that that IN cord-018017-c8myq6bi 489 7 the the DT cord-018017-c8myq6bi 489 8 virus virus NN cord-018017-c8myq6bi 489 9 will will MD cord-018017-c8myq6bi 489 10 be be VB cord-018017-c8myq6bi 489 11 influenza influenza NN cord-018017-c8myq6bi 489 12 A a NN cord-018017-c8myq6bi 489 13 ( ( -LRB- cord-018017-c8myq6bi 489 14 H5N1 H5N1 NNP cord-018017-c8myq6bi 489 15 or or CC cord-018017-c8myq6bi 489 16 H7N9 H7N9 NNP cord-018017-c8myq6bi 489 17 ) ) -RRB- cord-018017-c8myq6bi 489 18 that that WDT cord-018017-c8myq6bi 489 19 will will MD cord-018017-c8myq6bi 489 20 jump jump VB cord-018017-c8myq6bi 489 21 from from IN cord-018017-c8myq6bi 489 22 a a DT cord-018017-c8myq6bi 489 23 reservoir reservoir NN cord-018017-c8myq6bi 489 24 population population NN cord-018017-c8myq6bi 489 25 of of IN cord-018017-c8myq6bi 489 26 birds bird NNS cord-018017-c8myq6bi 489 27 and and CC cord-018017-c8myq6bi 489 28 establish establish VB cord-018017-c8myq6bi 489 29 human human NN cord-018017-c8myq6bi 489 30 - - HYPH cord-018017-c8myq6bi 489 31 to to IN cord-018017-c8myq6bi 489 32 - - HYPH cord-018017-c8myq6bi 489 33 human human JJ cord-018017-c8myq6bi 489 34 transmission transmission NN cord-018017-c8myq6bi 489 35 . . . cord-018017-c8myq6bi 490 1 The the DT cord-018017-c8myq6bi 490 2 pandemic pandemic NN cord-018017-c8myq6bi 490 3 will will MD cord-018017-c8myq6bi 490 4 be be VB cord-018017-c8myq6bi 490 5 a a DT cord-018017-c8myq6bi 490 6 global global JJ cord-018017-c8myq6bi 490 7 event event NN cord-018017-c8myq6bi 490 8 by by IN cord-018017-c8myq6bi 490 9 the the DT cord-018017-c8myq6bi 490 10 time time NN cord-018017-c8myq6bi 490 11 an an DT cord-018017-c8myq6bi 490 12 effective effective JJ cord-018017-c8myq6bi 490 13 vaccine vaccine NN cord-018017-c8myq6bi 490 14 is be VBZ cord-018017-c8myq6bi 490 15 available available JJ cord-018017-c8myq6bi 490 16 . . . cord-018017-c8myq6bi 491 1 Neuraminidase Neuraminidase NNP cord-018017-c8myq6bi 491 2 ( ( -LRB- cord-018017-c8myq6bi 491 3 NA NA NNP cord-018017-c8myq6bi 491 4 ) ) -RRB- cord-018017-c8myq6bi 491 5 inhibitors inhibitor NNS cord-018017-c8myq6bi 491 6 as as IN cord-018017-c8myq6bi 491 7 therapeutic therapeutic JJ cord-018017-c8myq6bi 491 8 and and CC cord-018017-c8myq6bi 491 9 prophylactic prophylactic JJ cord-018017-c8myq6bi 491 10 agents agent NNS cord-018017-c8myq6bi 491 11 in in IN cord-018017-c8myq6bi 491 12 the the DT cord-018017-c8myq6bi 491 13 setting setting NN cord-018017-c8myq6bi 491 14 of of IN cord-018017-c8myq6bi 491 15 pandemic pandemic NN cord-018017-c8myq6bi 491 16 influenza influenza NN cord-018017-c8myq6bi 491 17 A a NN cord-018017-c8myq6bi 491 18 ( ( -LRB- cord-018017-c8myq6bi 491 19 FLUA FLUA NNP cord-018017-c8myq6bi 491 20 ) ) -RRB- cord-018017-c8myq6bi 491 21 were be VBD cord-018017-c8myq6bi 491 22 called call VBN cord-018017-c8myq6bi 491 23 in in RP cord-018017-c8myq6bi 491 24 to to TO cord-018017-c8myq6bi 491 25 doubt doubt VB cord-018017-c8myq6bi 491 26 in in IN cord-018017-c8myq6bi 491 27 the the DT cord-018017-c8myq6bi 491 28 past past JJ cord-018017-c8myq6bi 491 29 decade decade NN cord-018017-c8myq6bi 492 1 ( ( -LRB- cord-018017-c8myq6bi 492 2 Michiels Michiels NNP cord-018017-c8myq6bi 492 3 et et NNP cord-018017-c8myq6bi 492 4 al al NNP cord-018017-c8myq6bi 492 5 . . . cord-018017-c8myq6bi 493 1 2013 2013 CD cord-018017-c8myq6bi 493 2 ; ; : cord-018017-c8myq6bi 493 3 Jefferson Jefferson NNP cord-018017-c8myq6bi 493 4 et et NNP cord-018017-c8myq6bi 493 5 al al NNP cord-018017-c8myq6bi 493 6 . . NNP cord-018017-c8myq6bi 493 7 2014 2014 CD cord-018017-c8myq6bi 493 8 ) ) -RRB- cord-018017-c8myq6bi 493 9 . . . cord-018017-c8myq6bi 494 1 Indeed indeed RB cord-018017-c8myq6bi 494 2 , , , cord-018017-c8myq6bi 494 3 100 100 CD cord-018017-c8myq6bi 494 4 % % NN cord-018017-c8myq6bi 494 5 of of IN cord-018017-c8myq6bi 494 6 isolates isolate NNS cord-018017-c8myq6bi 494 7 in in IN cord-018017-c8myq6bi 494 8 the the DT cord-018017-c8myq6bi 494 9 2008/2009 2008/2009 CD cord-018017-c8myq6bi 494 10 A A NNP cord-018017-c8myq6bi 494 11 / / SYM cord-018017-c8myq6bi 494 12 H1N1 H1N1 NNP cord-018017-c8myq6bi 494 13 pandemic pandemic NN cord-018017-c8myq6bi 494 14 were be VBD cord-018017-c8myq6bi 494 15 found find VBN cord-018017-c8myq6bi 494 16 to to TO cord-018017-c8myq6bi 494 17 be be VB cord-018017-c8myq6bi 494 18 resistant resistant JJ cord-018017-c8myq6bi 494 19 to to IN cord-018017-c8myq6bi 494 20 adamantanes adamantane NNS cord-018017-c8myq6bi 494 21 , , , cord-018017-c8myq6bi 494 22 and and CC cord-018017-c8myq6bi 494 23 resistance resistance NN cord-018017-c8myq6bi 494 24 to to IN cord-018017-c8myq6bi 494 25 oseltamivir oseltamivir FW cord-018017-c8myq6bi 494 26 ( ( -LRB- cord-018017-c8myq6bi 494 27 Tamiflu Tamiflu NNP cord-018017-c8myq6bi 494 28 ; ; : cord-018017-c8myq6bi 494 29 OSL OSL NNP cord-018017-c8myq6bi 494 30 ) ) -RRB- cord-018017-c8myq6bi 494 31 was be VBD cord-018017-c8myq6bi 494 32 observed observe VBN cord-018017-c8myq6bi 494 33 in in IN cord-018017-c8myq6bi 494 34 virus virus NN cord-018017-c8myq6bi 494 35 recovered recover VBN cord-018017-c8myq6bi 494 36 from from IN cord-018017-c8myq6bi 494 37 individuals individual NNS cord-018017-c8myq6bi 494 38 taking take VBG cord-018017-c8myq6bi 494 39 OSL OSL NNP cord-018017-c8myq6bi 494 40 therapeutically therapeutically RB cord-018017-c8myq6bi 494 41 or or CC cord-018017-c8myq6bi 494 42 prophylactically prophylactically RB cord-018017-c8myq6bi 494 43 ( ( -LRB- cord-018017-c8myq6bi 494 44 Dharan Dharan NNP cord-018017-c8myq6bi 494 45 et et NNP cord-018017-c8myq6bi 494 46 al al NNP cord-018017-c8myq6bi 494 47 . . . cord-018017-c8myq6bi 495 1 2008 2008 CD cord-018017-c8myq6bi 495 2 ; ; : cord-018017-c8myq6bi 495 3 CDC CDC NNP cord-018017-c8myq6bi 495 4 MMWR MMWR NNP cord-018017-c8myq6bi 495 5 2009 2009 CD cord-018017-c8myq6bi 495 6 ) ) -RRB- cord-018017-c8myq6bi 495 7 , , , cord-018017-c8myq6bi 495 8 while while IN cord-018017-c8myq6bi 495 9 effect effect NN cord-018017-c8myq6bi 495 10 on on IN cord-018017-c8myq6bi 495 11 duration duration NN cord-018017-c8myq6bi 495 12 of of IN cord-018017-c8myq6bi 495 13 shedding shedding NN cord-018017-c8myq6bi 495 14 was be VBD cord-018017-c8myq6bi 495 15 not not RB cord-018017-c8myq6bi 495 16 impacted impact VBN cord-018017-c8myq6bi 495 17 . . . cord-018017-c8myq6bi 496 1 A a DT cord-018017-c8myq6bi 496 2 recent recent JJ cord-018017-c8myq6bi 496 3 outbreak outbreak NN cord-018017-c8myq6bi 496 4 of of IN cord-018017-c8myq6bi 496 5 an an DT cord-018017-c8myq6bi 496 6 influenza influenza NN cord-018017-c8myq6bi 496 7 A a NN cord-018017-c8myq6bi 496 8 ( ( -LRB- cord-018017-c8myq6bi 496 9 H7N9 H7N9 NNP cord-018017-c8myq6bi 496 10 ) ) -RRB- cord-018017-c8myq6bi 496 11 virus virus NN cord-018017-c8myq6bi 496 12 caused cause VBD cord-018017-c8myq6bi 496 13 137 137 CD cord-018017-c8myq6bi 496 14 cases case NNS cord-018017-c8myq6bi 496 15 and and CC cord-018017-c8myq6bi 496 16 45 45 CD cord-018017-c8myq6bi 496 17 deaths death NNS cord-018017-c8myq6bi 496 18 in in IN cord-018017-c8myq6bi 496 19 China China NNP cord-018017-c8myq6bi 496 20 revealed reveal VBD cord-018017-c8myq6bi 496 21 a a DT cord-018017-c8myq6bi 496 22 novel novel JJ cord-018017-c8myq6bi 496 23 NA NA NNP cord-018017-c8myq6bi 496 24 mutation mutation NN cord-018017-c8myq6bi 496 25 R292 r292 XX cord-018017-c8myq6bi 496 26 K k XX cord-018017-c8myq6bi 496 27 resulting result VBG cord-018017-c8myq6bi 496 28 in in IN cord-018017-c8myq6bi 496 29 high high JJ cord-018017-c8myq6bi 496 30 level level NN cord-018017-c8myq6bi 496 31 resistance resistance NN cord-018017-c8myq6bi 496 32 to to IN cord-018017-c8myq6bi 496 33 OSL OSL NNP cord-018017-c8myq6bi 496 34 ( ( -LRB- cord-018017-c8myq6bi 496 35 Wang Wang NNP cord-018017-c8myq6bi 496 36 et et NNP cord-018017-c8myq6bi 496 37 al al NNP cord-018017-c8myq6bi 496 38 . . NNP cord-018017-c8myq6bi 496 39 2014 2014 CD cord-018017-c8myq6bi 496 40 ) ) -RRB- cord-018017-c8myq6bi 496 41 . . . cord-018017-c8myq6bi 497 1 Therapeutic therapeutic JJ cord-018017-c8myq6bi 497 2 options option NNS cord-018017-c8myq6bi 497 3 for for IN cord-018017-c8myq6bi 497 4 treatment treatment NN cord-018017-c8myq6bi 497 5 of of IN cord-018017-c8myq6bi 497 6 individuals individual NNS cord-018017-c8myq6bi 497 7 with with IN cord-018017-c8myq6bi 497 8 complicated complicated JJ cord-018017-c8myq6bi 497 9 influenza influenza NN cord-018017-c8myq6bi 497 10 A a NN cord-018017-c8myq6bi 497 11 are be VBP cord-018017-c8myq6bi 497 12 severely severely RB cord-018017-c8myq6bi 497 13 limited limit VBN cord-018017-c8myq6bi 497 14 , , , cord-018017-c8myq6bi 497 15 perhaps perhaps RB cord-018017-c8myq6bi 497 16 no no DT cord-018017-c8myq6bi 497 17 options option NNS cord-018017-c8myq6bi 497 18 . . . cord-018017-c8myq6bi 498 1 Pandemic pandemic NN cord-018017-c8myq6bi 498 2 strains strain VBZ cord-018017-c8myq6bi 498 3 such such JJ cord-018017-c8myq6bi 498 4 as as IN cord-018017-c8myq6bi 498 5 A A NNP cord-018017-c8myq6bi 498 6 / / SYM cord-018017-c8myq6bi 498 7 H1N1pdm09 H1N1pdm09 NNP cord-018017-c8myq6bi 498 8 carried carry VBD cord-018017-c8myq6bi 498 9 significant significant JJ cord-018017-c8myq6bi 498 10 morbidity morbidity NN cord-018017-c8myq6bi 498 11 and and CC cord-018017-c8myq6bi 498 12 mortality mortality NN cord-018017-c8myq6bi 498 13 , , , cord-018017-c8myq6bi 498 14 particularly particularly RB cord-018017-c8myq6bi 498 15 in in IN cord-018017-c8myq6bi 498 16 those those DT cord-018017-c8myq6bi 498 17 who who WP cord-018017-c8myq6bi 498 18 had have VBD cord-018017-c8myq6bi 498 19 not not RB cord-018017-c8myq6bi 498 20 experienced experience VBN cord-018017-c8myq6bi 498 21 H1-strain H1-strain NNPS cord-018017-c8myq6bi 498 22 influenza influenza NN cord-018017-c8myq6bi 498 23 in in IN cord-018017-c8myq6bi 498 24 their -PRON- PRP$ cord-018017-c8myq6bi 498 25 lifetime lifetime NN cord-018017-c8myq6bi 498 26 . . . cord-018017-c8myq6bi 499 1 We -PRON- PRP cord-018017-c8myq6bi 499 2 are be VBP cord-018017-c8myq6bi 499 3 also also RB cord-018017-c8myq6bi 499 4 witnessing witness VBG cord-018017-c8myq6bi 499 5 more more RBR cord-018017-c8myq6bi 499 6 rapidly rapidly RB cord-018017-c8myq6bi 499 7 emerging emerge VBG cord-018017-c8myq6bi 499 8 highly highly RB cord-018017-c8myq6bi 499 9 pathogenic pathogenic JJ cord-018017-c8myq6bi 499 10 avian avian JJ cord-018017-c8myq6bi 499 11 influenza influenza NN cord-018017-c8myq6bi 499 12 strains strain NNS cord-018017-c8myq6bi 499 13 that that WDT cord-018017-c8myq6bi 499 14 are be VBP cord-018017-c8myq6bi 499 15 resulting result VBG cord-018017-c8myq6bi 499 16 in in IN cord-018017-c8myq6bi 499 17 human human JJ cord-018017-c8myq6bi 499 18 infection infection NN cord-018017-c8myq6bi 499 19 ; ; : cord-018017-c8myq6bi 499 20 some some DT cord-018017-c8myq6bi 499 21 such such JJ cord-018017-c8myq6bi 499 22 as as IN cord-018017-c8myq6bi 499 23 A A NNP cord-018017-c8myq6bi 499 24 / / SYM cord-018017-c8myq6bi 499 25 H5N1 H5N1 NNP cord-018017-c8myq6bi 499 26 and and CC cord-018017-c8myq6bi 499 27 A A NNP cord-018017-c8myq6bi 499 28 / / SYM cord-018017-c8myq6bi 499 29 H7N9 H7N9 NNP cord-018017-c8myq6bi 499 30 appear appear VB cord-018017-c8myq6bi 499 31 to to IN cord-018017-c8myq6bi 499 32 becoming become VBG cord-018017-c8myq6bi 499 33 more more RBR cord-018017-c8myq6bi 499 34 efficient efficient JJ cord-018017-c8myq6bi 499 35 in in IN cord-018017-c8myq6bi 499 36 person person NN cord-018017-c8myq6bi 499 37 - - HYPH cord-018017-c8myq6bi 499 38 to to IN cord-018017-c8myq6bi 499 39 - - HYPH cord-018017-c8myq6bi 499 40 person person NN cord-018017-c8myq6bi 499 41 transmission transmission NN cord-018017-c8myq6bi 499 42 , , , cord-018017-c8myq6bi 499 43 and and CC cord-018017-c8myq6bi 499 44 reports report NNS cord-018017-c8myq6bi 499 45 suggest suggest VBP cord-018017-c8myq6bi 499 46 OSL OSL NNP cord-018017-c8myq6bi 499 47 resistance resistance NN cord-018017-c8myq6bi 499 48 develops develop VBZ cord-018017-c8myq6bi 499 49 during during IN cord-018017-c8myq6bi 499 50 treatment treatment NN cord-018017-c8myq6bi 499 51 ( ( -LRB- cord-018017-c8myq6bi 499 52 de de FW cord-018017-c8myq6bi 499 53 Jong Jong NNP cord-018017-c8myq6bi 499 54 et et NNP cord-018017-c8myq6bi 499 55 al al NNP cord-018017-c8myq6bi 499 56 . . . cord-018017-c8myq6bi 500 1 2005 2005 CD cord-018017-c8myq6bi 500 2 ; ; : cord-018017-c8myq6bi 500 3 Lam Lam NNP cord-018017-c8myq6bi 500 4 et et NNP cord-018017-c8myq6bi 500 5 al al NNP cord-018017-c8myq6bi 500 6 . . NNP cord-018017-c8myq6bi 500 7 2015 2015 CD cord-018017-c8myq6bi 500 8 ) ) -RRB- cord-018017-c8myq6bi 500 9 . . . cord-018017-c8myq6bi 501 1 We -PRON- PRP cord-018017-c8myq6bi 501 2 are be VBP cord-018017-c8myq6bi 501 3 not not RB cord-018017-c8myq6bi 501 4 ready ready JJ cord-018017-c8myq6bi 501 5 for for IN cord-018017-c8myq6bi 501 6 an an DT cord-018017-c8myq6bi 501 7 outbreak outbreak NN cord-018017-c8myq6bi 501 8 of of IN cord-018017-c8myq6bi 501 9 avian avian JJ cord-018017-c8myq6bi 501 10 flu flu NN cord-018017-c8myq6bi 501 11 or or CC cord-018017-c8myq6bi 501 12 any any DT cord-018017-c8myq6bi 501 13 other other JJ cord-018017-c8myq6bi 501 14 emerging emerge VBG cord-018017-c8myq6bi 501 15 single single RB cord-018017-c8myq6bi 501 16 - - HYPH cord-018017-c8myq6bi 501 17 stranded strand VBN cord-018017-c8myq6bi 501 18 RNA RNA NNP cord-018017-c8myq6bi 501 19 virus virus NN cord-018017-c8myq6bi 501 20 . . . cord-018017-c8myq6bi 502 1 Why why WRB cord-018017-c8myq6bi 502 2 not not RB cord-018017-c8myq6bi 502 3 ? ? . cord-018017-c8myq6bi 503 1 An an DT cord-018017-c8myq6bi 503 2 estimate estimate NN cord-018017-c8myq6bi 503 3 for for IN cord-018017-c8myq6bi 503 4 the the DT cord-018017-c8myq6bi 503 5 time time NN cord-018017-c8myq6bi 503 6 and and CC cord-018017-c8myq6bi 503 7 cost cost VBD cord-018017-c8myq6bi 503 8 to to TO cord-018017-c8myq6bi 503 9 develop develop VB cord-018017-c8myq6bi 503 10 a a DT cord-018017-c8myq6bi 503 11 new new JJ cord-018017-c8myq6bi 503 12 drug drug NN cord-018017-c8myq6bi 503 13 is be VBZ cord-018017-c8myq6bi 503 14 10 10 CD cord-018017-c8myq6bi 503 15 years year NNS cord-018017-c8myq6bi 503 16 and and CC cord-018017-c8myq6bi 503 17 $ $ $ cord-018017-c8myq6bi 503 18 1 1 CD cord-018017-c8myq6bi 503 19 billion billion CD cord-018017-c8myq6bi 503 20 . . . cord-018017-c8myq6bi 504 1 The the DT cord-018017-c8myq6bi 504 2 commercial commercial JJ cord-018017-c8myq6bi 504 3 use use NN cord-018017-c8myq6bi 504 4 of of IN cord-018017-c8myq6bi 504 5 a a DT cord-018017-c8myq6bi 504 6 drug drug NN cord-018017-c8myq6bi 504 7 for for IN cord-018017-c8myq6bi 504 8 an an DT cord-018017-c8myq6bi 504 9 emerging emerge VBG cord-018017-c8myq6bi 504 10 infection infection NN cord-018017-c8myq6bi 504 11 is be VBZ cord-018017-c8myq6bi 504 12 hard hard JJ cord-018017-c8myq6bi 504 13 to to TO cord-018017-c8myq6bi 504 14 estimate estimate VB cord-018017-c8myq6bi 504 15 since since IN cord-018017-c8myq6bi 504 16 by by IN cord-018017-c8myq6bi 504 17 definition definition NN cord-018017-c8myq6bi 504 18 when when WRB cord-018017-c8myq6bi 504 19 you -PRON- PRP cord-018017-c8myq6bi 504 20 start start VBP cord-018017-c8myq6bi 504 21 development development NN cord-018017-c8myq6bi 504 22 the the DT cord-018017-c8myq6bi 504 23 infection infection NN cord-018017-c8myq6bi 504 24 has have VBZ cord-018017-c8myq6bi 504 25 not not RB cord-018017-c8myq6bi 504 26 emerged emerge VBN cord-018017-c8myq6bi 504 27 . . . cord-018017-c8myq6bi 505 1 Most Most JJS cord-018017-c8myq6bi 505 2 of of IN cord-018017-c8myq6bi 505 3 us -PRON- PRP cord-018017-c8myq6bi 505 4 would would MD cord-018017-c8myq6bi 505 5 be be VB cord-018017-c8myq6bi 505 6 unlikely unlikely JJ cord-018017-c8myq6bi 505 7 to to TO cord-018017-c8myq6bi 505 8 use use VB cord-018017-c8myq6bi 505 9 our -PRON- PRP$ cord-018017-c8myq6bi 505 10 retirement retirement NN cord-018017-c8myq6bi 505 11 savings saving NNS cord-018017-c8myq6bi 505 12 to to TO cord-018017-c8myq6bi 505 13 invest invest VB cord-018017-c8myq6bi 505 14 in in IN cord-018017-c8myq6bi 505 15 a a DT cord-018017-c8myq6bi 505 16 drug drug NN cord-018017-c8myq6bi 505 17 development development NN cord-018017-c8myq6bi 505 18 project project NN cord-018017-c8myq6bi 505 19 with with IN cord-018017-c8myq6bi 505 20 no no DT cord-018017-c8myq6bi 505 21 reliable reliable JJ cord-018017-c8myq6bi 505 22 way way NN cord-018017-c8myq6bi 505 23 to to TO cord-018017-c8myq6bi 505 24 expect expect VB cord-018017-c8myq6bi 505 25 a a DT cord-018017-c8myq6bi 505 26 return return NN cord-018017-c8myq6bi 505 27 on on IN cord-018017-c8myq6bi 505 28 our -PRON- PRP$ cord-018017-c8myq6bi 505 29 investment investment NN cord-018017-c8myq6bi 505 30 . . . cord-018017-c8myq6bi 506 1 It -PRON- PRP cord-018017-c8myq6bi 506 2 is be VBZ cord-018017-c8myq6bi 506 3 a a DT cord-018017-c8myq6bi 506 4 poor poor JJ cord-018017-c8myq6bi 506 5 business business NN cord-018017-c8myq6bi 506 6 model model NN cord-018017-c8myq6bi 506 7 . . . cord-018017-c8myq6bi 507 1 When when WRB cord-018017-c8myq6bi 507 2 you -PRON- PRP cord-018017-c8myq6bi 507 3 consider consider VBP cord-018017-c8myq6bi 507 4 there there EX cord-018017-c8myq6bi 507 5 may may MD cord-018017-c8myq6bi 507 6 be be VB cord-018017-c8myq6bi 507 7 hundreds hundred NNS cord-018017-c8myq6bi 507 8 of of IN cord-018017-c8myq6bi 507 9 emerging emerge VBG cord-018017-c8myq6bi 507 10 infectious infectious JJ cord-018017-c8myq6bi 507 11 diseases disease NNS cord-018017-c8myq6bi 507 12 each each DT cord-018017-c8myq6bi 507 13 times time NNS cord-018017-c8myq6bi 507 14 10 10 CD cord-018017-c8myq6bi 507 15 years year NNS cord-018017-c8myq6bi 507 16 and and CC cord-018017-c8myq6bi 507 17 $ $ $ cord-018017-c8myq6bi 507 18 1 1 CD cord-018017-c8myq6bi 507 19 billion billion CD cord-018017-c8myq6bi 507 20 each each DT cord-018017-c8myq6bi 507 21 the the DT cord-018017-c8myq6bi 507 22 task task NN cord-018017-c8myq6bi 507 23 is be VBZ cord-018017-c8myq6bi 507 24 daunting daunt VBG cord-018017-c8myq6bi 507 25 . . . cord-018017-c8myq6bi 508 1 On on IN cord-018017-c8myq6bi 508 2 which which WDT cord-018017-c8myq6bi 508 3 disease disease NN cord-018017-c8myq6bi 508 4 should should MD cord-018017-c8myq6bi 508 5 we -PRON- PRP cord-018017-c8myq6bi 508 6 focus focus VB cord-018017-c8myq6bi 508 7 ? ? . cord-018017-c8myq6bi 509 1 Consider consider VB cord-018017-c8myq6bi 509 2 the the DT cord-018017-c8myq6bi 509 3 Ebola Ebola NNP cord-018017-c8myq6bi 509 4 drug drug NN cord-018017-c8myq6bi 509 5 AVI-7537 AVI-7537 NNS cord-018017-c8myq6bi 509 6 . . . cord-018017-c8myq6bi 510 1 The the DT cord-018017-c8myq6bi 510 2 Ebola Ebola NNP cord-018017-c8myq6bi 510 3 therapeutic therapeutic JJ cord-018017-c8myq6bi 510 4 project project NN cord-018017-c8myq6bi 510 5 began begin VBD cord-018017-c8myq6bi 510 6 in in IN cord-018017-c8myq6bi 510 7 2004 2004 CD cord-018017-c8myq6bi 510 8 following follow VBG cord-018017-c8myq6bi 510 9 a a DT cord-018017-c8myq6bi 510 10 laboratory laboratory NN cord-018017-c8myq6bi 510 11 accident accident NN cord-018017-c8myq6bi 510 12 at at IN cord-018017-c8myq6bi 510 13 USAMRIID USAMRIID NNP cord-018017-c8myq6bi 510 14 . . . cord-018017-c8myq6bi 511 1 We -PRON- PRP cord-018017-c8myq6bi 511 2 identified identify VBD cord-018017-c8myq6bi 511 3 three three CD cord-018017-c8myq6bi 511 4 compounds compound NNS cord-018017-c8myq6bi 511 5 each each DT cord-018017-c8myq6bi 511 6 with with IN cord-018017-c8myq6bi 511 7 activity activity NN cord-018017-c8myq6bi 511 8 and and CC cord-018017-c8myq6bi 511 9 when when WRB cord-018017-c8myq6bi 511 10 combined combine VBN cord-018017-c8myq6bi 511 11 we -PRON- PRP cord-018017-c8myq6bi 511 12 observed observe VBD cord-018017-c8myq6bi 511 13 unprecedented unprecedented JJ cord-018017-c8myq6bi 511 14 efficacy efficacy NN cord-018017-c8myq6bi 511 15 in in IN cord-018017-c8myq6bi 511 16 a a DT cord-018017-c8myq6bi 511 17 lethal lethal JJ cord-018017-c8myq6bi 511 18 challenge challenge NN cord-018017-c8myq6bi 511 19 primate primate JJ cord-018017-c8myq6bi 511 20 animal animal NN cord-018017-c8myq6bi 511 21 model model NN cord-018017-c8myq6bi 511 22 ( ( -LRB- cord-018017-c8myq6bi 511 23 Warfield Warfield NNP cord-018017-c8myq6bi 511 24 et et NNP cord-018017-c8myq6bi 511 25 al al NNP cord-018017-c8myq6bi 511 26 . . . cord-018017-c8myq6bi 511 27 2006 2006 CD cord-018017-c8myq6bi 511 28 ) ) -RRB- cord-018017-c8myq6bi 511 29 . . . cord-018017-c8myq6bi 512 1 Hundreds hundred NNS cord-018017-c8myq6bi 512 2 of of IN cord-018017-c8myq6bi 512 3 experiments experiment NNS cord-018017-c8myq6bi 512 4 over over IN cord-018017-c8myq6bi 512 5 the the DT cord-018017-c8myq6bi 512 6 next next JJ cord-018017-c8myq6bi 512 7 3 3 CD cord-018017-c8myq6bi 512 8 years year NNS cord-018017-c8myq6bi 512 9 optimized optimize VBN cord-018017-c8myq6bi 512 10 these these DT cord-018017-c8myq6bi 512 11 agents agent NNS cord-018017-c8myq6bi 512 12 ( ( -LRB- cord-018017-c8myq6bi 512 13 Swenson Swenson NNP cord-018017-c8myq6bi 512 14 et et NNP cord-018017-c8myq6bi 512 15 al al NNP cord-018017-c8myq6bi 512 16 . . . cord-018017-c8myq6bi 512 17 2009 2009 CD cord-018017-c8myq6bi 512 18 ) ) -RRB- cord-018017-c8myq6bi 512 19 . . . cord-018017-c8myq6bi 513 1 We -PRON- PRP cord-018017-c8myq6bi 513 2 were be VBD cord-018017-c8myq6bi 513 3 able able JJ cord-018017-c8myq6bi 513 4 to to TO cord-018017-c8myq6bi 513 5 obtain obtain VB cord-018017-c8myq6bi 513 6 research research NN cord-018017-c8myq6bi 513 7 grants grant NNS cord-018017-c8myq6bi 513 8 from from IN cord-018017-c8myq6bi 513 9 the the DT cord-018017-c8myq6bi 513 10 Transformational Transformational NNP cord-018017-c8myq6bi 513 11 Medical Medical NNP cord-018017-c8myq6bi 513 12 Technologies Technologies NNPS cord-018017-c8myq6bi 513 13 ( ( -LRB- cord-018017-c8myq6bi 513 14 TMT TMT NNP cord-018017-c8myq6bi 513 15 ) ) -RRB- cord-018017-c8myq6bi 513 16 division division NN cord-018017-c8myq6bi 513 17 of of IN cord-018017-c8myq6bi 513 18 the the DT cord-018017-c8myq6bi 513 19 Defense Defense NNP cord-018017-c8myq6bi 513 20 Threat Threat NNP cord-018017-c8myq6bi 513 21 Reduction Reduction NNP cord-018017-c8myq6bi 513 22 Agency Agency NNP cord-018017-c8myq6bi 513 23 ( ( -LRB- cord-018017-c8myq6bi 513 24 DTRA DTRA NNP cord-018017-c8myq6bi 513 25 ) ) -RRB- cord-018017-c8myq6bi 513 26 within within IN cord-018017-c8myq6bi 513 27 the the DT cord-018017-c8myq6bi 513 28 Department Department NNP cord-018017-c8myq6bi 513 29 of of IN cord-018017-c8myq6bi 513 30 Defense Defense NNP cord-018017-c8myq6bi 513 31 ( ( -LRB- cord-018017-c8myq6bi 513 32 DOD DOD NNP cord-018017-c8myq6bi 513 33 ) ) -RRB- cord-018017-c8myq6bi 513 34 and and CC cord-018017-c8myq6bi 513 35 we -PRON- PRP cord-018017-c8myq6bi 513 36 completed complete VBD cord-018017-c8myq6bi 513 37 proof proof NN cord-018017-c8myq6bi 513 38 of of IN cord-018017-c8myq6bi 513 39 efficacy efficacy NN cord-018017-c8myq6bi 513 40 studies study NNS cord-018017-c8myq6bi 513 41 ( ( -LRB- cord-018017-c8myq6bi 513 42 Warren Warren NNP cord-018017-c8myq6bi 513 43 et et NNP cord-018017-c8myq6bi 513 44 al al NNP cord-018017-c8myq6bi 513 45 . . NNP cord-018017-c8myq6bi 513 46 2010 2010 CD cord-018017-c8myq6bi 513 47 ) ) -RRB- cord-018017-c8myq6bi 513 48 . . . cord-018017-c8myq6bi 514 1 This this DT cord-018017-c8myq6bi 514 2 led lead VBD cord-018017-c8myq6bi 514 3 to to IN cord-018017-c8myq6bi 514 4 submission submission NN cord-018017-c8myq6bi 514 5 of of IN cord-018017-c8myq6bi 514 6 an an DT cord-018017-c8myq6bi 514 7 investigational investigational JJ cord-018017-c8myq6bi 514 8 new new JJ cord-018017-c8myq6bi 514 9 drug drug NN cord-018017-c8myq6bi 514 10 application application NN cord-018017-c8myq6bi 514 11 ( ( -LRB- cord-018017-c8myq6bi 514 12 IND IND NNP cord-018017-c8myq6bi 514 13 ) ) -RRB- cord-018017-c8myq6bi 514 14 to to IN cord-018017-c8myq6bi 514 15 the the DT cord-018017-c8myq6bi 514 16 Food Food NNP cord-018017-c8myq6bi 514 17 and and CC cord-018017-c8myq6bi 514 18 Drug Drug NNP cord-018017-c8myq6bi 514 19 Agency Agency NNP cord-018017-c8myq6bi 514 20 ( ( -LRB- cord-018017-c8myq6bi 514 21 FDA FDA NNP cord-018017-c8myq6bi 514 22 ) ) -RRB- cord-018017-c8myq6bi 514 23 and and CC cord-018017-c8myq6bi 514 24 phase phase VB cord-018017-c8myq6bi 514 25 I -PRON- PRP cord-018017-c8myq6bi 514 26 safety safety NN cord-018017-c8myq6bi 514 27 and and CC cord-018017-c8myq6bi 514 28 tolerability tolerability NN cord-018017-c8myq6bi 514 29 studies study NNS cord-018017-c8myq6bi 514 30 were be VBD cord-018017-c8myq6bi 514 31 conducted conduct VBN cord-018017-c8myq6bi 514 32 I -PRON- PRP cord-018017-c8myq6bi 514 33 healthy healthy JJ cord-018017-c8myq6bi 514 34 human human JJ cord-018017-c8myq6bi 514 35 volunteers volunteer NNS cord-018017-c8myq6bi 514 36 ( ( -LRB- cord-018017-c8myq6bi 514 37 Heald Heald NNP cord-018017-c8myq6bi 514 38 et et NNP cord-018017-c8myq6bi 514 39 al al NNP cord-018017-c8myq6bi 514 40 . . NNP cord-018017-c8myq6bi 514 41 2014 2014 CD cord-018017-c8myq6bi 514 42 ) ) -RRB- cord-018017-c8myq6bi 514 43 . . . cord-018017-c8myq6bi 515 1 After after IN cord-018017-c8myq6bi 515 2 11 11 CD cord-018017-c8myq6bi 515 3 years year NNS cord-018017-c8myq6bi 515 4 of of IN cord-018017-c8myq6bi 515 5 continuous continuous JJ cord-018017-c8myq6bi 515 6 effort effort NN cord-018017-c8myq6bi 515 7 , , , cord-018017-c8myq6bi 515 8 we -PRON- PRP cord-018017-c8myq6bi 515 9 completed complete VBD cord-018017-c8myq6bi 515 10 key key JJ cord-018017-c8myq6bi 515 11 aspects aspect NNS cord-018017-c8myq6bi 515 12 related relate VBN cord-018017-c8myq6bi 515 13 to to IN cord-018017-c8myq6bi 515 14 the the DT cord-018017-c8myq6bi 515 15 FDA FDA NNP cord-018017-c8myq6bi 515 16 approval approval NN cord-018017-c8myq6bi 515 17 process process NN cord-018017-c8myq6bi 515 18 under under IN cord-018017-c8myq6bi 515 19 the the DT cord-018017-c8myq6bi 515 20 " " `` cord-018017-c8myq6bi 515 21 Animal Animal NNP cord-018017-c8myq6bi 515 22 Rule Rule NNP cord-018017-c8myq6bi 515 23 " " '' cord-018017-c8myq6bi 515 24 and and CC cord-018017-c8myq6bi 515 25 we -PRON- PRP cord-018017-c8myq6bi 515 26 streamlined streamline VBD cord-018017-c8myq6bi 515 27 our -PRON- PRP$ cord-018017-c8myq6bi 515 28 treatment treatment NN cord-018017-c8myq6bi 515 29 to to IN cord-018017-c8myq6bi 515 30 a a DT cord-018017-c8myq6bi 515 31 single single JJ cord-018017-c8myq6bi 515 32 agent agent NN cord-018017-c8myq6bi 515 33 , , , cord-018017-c8myq6bi 515 34 AVI-7537 AVI-7537 NNP cord-018017-c8myq6bi 515 35 ( ( -LRB- cord-018017-c8myq6bi 515 36 Warren Warren NNP cord-018017-c8myq6bi 515 37 et et NNP cord-018017-c8myq6bi 515 38 al al NNP cord-018017-c8myq6bi 515 39 . . NNP cord-018017-c8myq6bi 515 40 2015 2015 CD cord-018017-c8myq6bi 515 41 ) ) -RRB- cord-018017-c8myq6bi 515 42 . . . cord-018017-c8myq6bi 516 1 However however RB cord-018017-c8myq6bi 516 2 , , , cord-018017-c8myq6bi 516 3 shortly shortly RB cord-018017-c8myq6bi 516 4 before before IN cord-018017-c8myq6bi 516 5 the the DT cord-018017-c8myq6bi 516 6 Ebola Ebola NNP cord-018017-c8myq6bi 516 7 outbreak outbreak NN cord-018017-c8myq6bi 516 8 in in IN cord-018017-c8myq6bi 516 9 Western Western NNP cord-018017-c8myq6bi 516 10 Africa Africa NNP cord-018017-c8myq6bi 516 11 , , , cord-018017-c8myq6bi 516 12 the the DT cord-018017-c8myq6bi 516 13 US US NNP cord-018017-c8myq6bi 516 14 government government NN cord-018017-c8myq6bi 516 15 " " `` cord-018017-c8myq6bi 516 16 budget budget NN cord-018017-c8myq6bi 516 17 sequester sequester NN cord-018017-c8myq6bi 516 18 " " '' cord-018017-c8myq6bi 516 19 cancelled cancel VBD cord-018017-c8myq6bi 516 20 our -PRON- PRP$ cord-018017-c8myq6bi 516 21 project project NN cord-018017-c8myq6bi 516 22 and and CC cord-018017-c8myq6bi 516 23 the the DT cord-018017-c8myq6bi 516 24 most most RBS cord-018017-c8myq6bi 516 25 advanced advanced JJ cord-018017-c8myq6bi 516 26 therapeutic therapeutic JJ cord-018017-c8myq6bi 516 27 on on IN cord-018017-c8myq6bi 516 28 the the DT cord-018017-c8myq6bi 516 29 planet planet NN cord-018017-c8myq6bi 516 30 was be VBD cord-018017-c8myq6bi 516 31 not not RB cord-018017-c8myq6bi 516 32 deployed deploy VBN cord-018017-c8myq6bi 516 33 to to TO cord-018017-c8myq6bi 516 34 treat treat VB cord-018017-c8myq6bi 516 35 those those DT cord-018017-c8myq6bi 516 36 infected infect VBN cord-018017-c8myq6bi 516 37 during during IN cord-018017-c8myq6bi 516 38 the the DT cord-018017-c8myq6bi 516 39 outbreak outbreak NN cord-018017-c8myq6bi 516 40 . . . cord-018017-c8myq6bi 517 1 As as IN cord-018017-c8myq6bi 517 2 the the DT cord-018017-c8myq6bi 517 3 outbreak outbreak NN cord-018017-c8myq6bi 517 4 continued continue VBD cord-018017-c8myq6bi 517 5 , , , cord-018017-c8myq6bi 517 6 we -PRON- PRP cord-018017-c8myq6bi 517 7 found find VBD cord-018017-c8myq6bi 517 8 no no DT cord-018017-c8myq6bi 517 9 viral viral JJ cord-018017-c8myq6bi 517 10 resistance resistance NN cord-018017-c8myq6bi 517 11 of of IN cord-018017-c8myq6bi 517 12 AVI-7537 AVI-7537 NNS cord-018017-c8myq6bi 517 13 unlike unlike IN cord-018017-c8myq6bi 517 14 the the DT cord-018017-c8myq6bi 517 15 monoclonal monoclonal JJ cord-018017-c8myq6bi 517 16 antibody antibody NN cord-018017-c8myq6bi 517 17 therapy therapy NN cord-018017-c8myq6bi 517 18 in in IN cord-018017-c8myq6bi 517 19 use use NN cord-018017-c8myq6bi 518 1 ( ( -LRB- cord-018017-c8myq6bi 518 2 Khiabanian Khiabanian NNP cord-018017-c8myq6bi 518 3 et et FW cord-018017-c8myq6bi 518 4 al al NNP cord-018017-c8myq6bi 518 5 . . NNP cord-018017-c8myq6bi 518 6 2014 2014 CD cord-018017-c8myq6bi 518 7 ) ) -RRB- cord-018017-c8myq6bi 518 8 . . . cord-018017-c8myq6bi 519 1 AVI-7537 AVI-7537 NNS cord-018017-c8myq6bi 519 2 sits sit VBZ cord-018017-c8myq6bi 519 3 on on IN cord-018017-c8myq6bi 519 4 a a DT cord-018017-c8myq6bi 519 5 shelf shelf NN cord-018017-c8myq6bi 519 6 , , , cord-018017-c8myq6bi 519 7 a a DT cord-018017-c8myq6bi 519 8 political political JJ cord-018017-c8myq6bi 519 9 casualty casualty NN cord-018017-c8myq6bi 519 10 and and CC cord-018017-c8myq6bi 519 11 an an DT cord-018017-c8myq6bi 519 12 unfavorable unfavorable JJ cord-018017-c8myq6bi 519 13 business business NN cord-018017-c8myq6bi 519 14 model model NN cord-018017-c8myq6bi 519 15 . . . cord-018017-c8myq6bi 520 1 The the DT cord-018017-c8myq6bi 520 2 global global JJ cord-018017-c8myq6bi 520 3 virosphere virosphere NN cord-018017-c8myq6bi 520 4 may may MD cord-018017-c8myq6bi 520 5 contain contain VB cord-018017-c8myq6bi 520 6 up up IN cord-018017-c8myq6bi 520 7 to to TO cord-018017-c8myq6bi 520 8 10 10 CD cord-018017-c8myq6bi 520 9 31 31 CD cord-018017-c8myq6bi 520 10 virus virus NN cord-018017-c8myq6bi 520 11 / / SYM cord-018017-c8myq6bi 520 12 virus virus NN cord-018017-c8myq6bi 520 13 - - HYPH cord-018017-c8myq6bi 520 14 like like JJ cord-018017-c8myq6bi 520 15 particles particle NNS cord-018017-c8myq6bi 520 16 ( ( -LRB- cord-018017-c8myq6bi 520 17 Suttle Suttle NNP cord-018017-c8myq6bi 520 18 2005 2005 CD cord-018017-c8myq6bi 520 19 ) ) -RRB- cord-018017-c8myq6bi 520 20 , , , cord-018017-c8myq6bi 520 21 the the DT cord-018017-c8myq6bi 520 22 greatest great JJS cord-018017-c8myq6bi 520 23 reservoir reservoir NN cord-018017-c8myq6bi 520 24 of of IN cord-018017-c8myq6bi 520 25 genetic genetic JJ cord-018017-c8myq6bi 520 26 diversity diversity NN cord-018017-c8myq6bi 520 27 . . . cord-018017-c8myq6bi 521 1 The the DT cord-018017-c8myq6bi 521 2 Earth Earth NNP cord-018017-c8myq6bi 521 3 's 's POS cord-018017-c8myq6bi 521 4 atmosphere atmosphere NN cord-018017-c8myq6bi 521 5 transports transport VBZ cord-018017-c8myq6bi 521 6 viruses virus NNS cord-018017-c8myq6bi 521 7 all all RB cord-018017-c8myq6bi 521 8 over over IN cord-018017-c8myq6bi 521 9 the the DT cord-018017-c8myq6bi 521 10 planet planet NN cord-018017-c8myq6bi 521 11 . . . cord-018017-c8myq6bi 522 1 Viruses virus NNS cord-018017-c8myq6bi 522 2 are be VBP cord-018017-c8myq6bi 522 3 found find VBN cord-018017-c8myq6bi 522 4 in in IN cord-018017-c8myq6bi 522 5 soil soil NN cord-018017-c8myq6bi 522 6 at at IN cord-018017-c8myq6bi 522 7 1.5 1.5 CD cord-018017-c8myq6bi 522 8 x x SYM cord-018017-c8myq6bi 522 9 10 10 CD cord-018017-c8myq6bi 522 10 8 8 CD cord-018017-c8myq6bi 522 11 to to IN cord-018017-c8myq6bi 522 12 6.4 6.4 CD cord-018017-c8myq6bi 522 13 x x SYM cord-018017-c8myq6bi 522 14 10 10 CD cord-018017-c8myq6bi 522 15 8 8 CD cord-018017-c8myq6bi 522 16 particles particle NNS cord-018017-c8myq6bi 522 17 per per IN cord-018017-c8myq6bi 522 18 gram gram NN cord-018017-c8myq6bi 522 19 of of IN cord-018017-c8myq6bi 522 20 dry dry JJ cord-018017-c8myq6bi 522 21 soil soil NN cord-018017-c8myq6bi 523 1 ( ( -LRB- cord-018017-c8myq6bi 523 2 Kimura Kimura NNP cord-018017-c8myq6bi 523 3 et et FW cord-018017-c8myq6bi 523 4 al al NNP cord-018017-c8myq6bi 523 5 . . NNP cord-018017-c8myq6bi 523 6 2008 2008 CD cord-018017-c8myq6bi 523 7 ) ) -RRB- cord-018017-c8myq6bi 523 8 . . . cord-018017-c8myq6bi 524 1 The the DT cord-018017-c8myq6bi 524 2 surface surface NN cord-018017-c8myq6bi 524 3 oceans ocean NNS cord-018017-c8myq6bi 524 4 carry carry VBP cord-018017-c8myq6bi 524 5 approximately approximately RB cord-018017-c8myq6bi 524 6 ten ten CD cord-018017-c8myq6bi 524 7 million million CD cord-018017-c8myq6bi 524 8 viral viral JJ cord-018017-c8myq6bi 524 9 particles particle NNS cord-018017-c8myq6bi 524 10 in in IN cord-018017-c8myq6bi 524 11 each each DT cord-018017-c8myq6bi 524 12 milliliter milliliter NN cord-018017-c8myq6bi 524 13 of of IN cord-018017-c8myq6bi 524 14 seawater seawater NN cord-018017-c8myq6bi 524 15 , , , cord-018017-c8myq6bi 524 16 most most JJS cord-018017-c8myq6bi 524 17 of of IN cord-018017-c8myq6bi 524 18 which which WDT cord-018017-c8myq6bi 524 19 are be VBP cord-018017-c8myq6bi 524 20 bacteriophages bacteriophage NNS cord-018017-c8myq6bi 524 21 ( ( -LRB- cord-018017-c8myq6bi 524 22 phage phage NN cord-018017-c8myq6bi 524 23 ) ) -RRB- cord-018017-c8myq6bi 524 24 . . . cord-018017-c8myq6bi 525 1 The the DT cord-018017-c8myq6bi 525 2 small small JJ cord-018017-c8myq6bi 525 3 viral viral JJ cord-018017-c8myq6bi 525 4 particles particle NNS cord-018017-c8myq6bi 525 5 are be VBP cord-018017-c8myq6bi 525 6 easily easily RB cord-018017-c8myq6bi 525 7 carried carry VBN cord-018017-c8myq6bi 525 8 into into IN cord-018017-c8myq6bi 525 9 the the DT cord-018017-c8myq6bi 525 10 upper upper JJ cord-018017-c8myq6bi 525 11 Environmental Environmental NNP cord-018017-c8myq6bi 525 12 Viral Viral NNP cord-018017-c8myq6bi 525 13 Reservoirs Reservoirs NNPS cord-018017-c8myq6bi 525 14 atmosphere atmosphere NN cord-018017-c8myq6bi 525 15 by by IN cord-018017-c8myq6bi 525 16 up up IN cord-018017-c8myq6bi 525 17 drafting draft VBG cord-018017-c8myq6bi 525 18 winds wind NNS cord-018017-c8myq6bi 525 19 . . . cord-018017-c8myq6bi 526 1 Bacteria Bacteria NNS cord-018017-c8myq6bi 526 2 are be VBP cord-018017-c8myq6bi 526 3 deposited deposit VBN cord-018017-c8myq6bi 526 4 from from IN cord-018017-c8myq6bi 526 5 the the DT cord-018017-c8myq6bi 526 6 atmosphere atmosphere NN cord-018017-c8myq6bi 526 7 at at IN cord-018017-c8myq6bi 526 8 a a DT cord-018017-c8myq6bi 526 9 rate rate NN cord-018017-c8myq6bi 526 10 of of IN cord-018017-c8myq6bi 526 11 0.3 0.3 CD cord-018017-c8myq6bi 526 12 to to TO cord-018017-c8myq6bi 526 13 8 8 CD cord-018017-c8myq6bi 526 14 x x SYM cord-018017-c8myq6bi 526 15 10 10 CD cord-018017-c8myq6bi 526 16 7 7 CD cord-018017-c8myq6bi 526 17 per per IN cord-018017-c8myq6bi 526 18 meter meter NN cord-018017-c8myq6bi 526 19 each each DT cord-018017-c8myq6bi 526 20 day day NN cord-018017-c8myq6bi 526 21 and and CC cord-018017-c8myq6bi 526 22 viral viral JJ cord-018017-c8myq6bi 526 23 deposition deposition NN cord-018017-c8myq6bi 526 24 rates rate NNS cord-018017-c8myq6bi 526 25 are be VBP cord-018017-c8myq6bi 526 26 9 9 CD cord-018017-c8myq6bi 526 27 - - SYM cord-018017-c8myq6bi 526 28 461 461 CD cord-018017-c8myq6bi 526 29 times time NNS cord-018017-c8myq6bi 526 30 greater great JJR cord-018017-c8myq6bi 527 1 ( ( -LRB- cord-018017-c8myq6bi 527 2 Reche Reche NNP cord-018017-c8myq6bi 527 3 et et FW cord-018017-c8myq6bi 527 4 al al NNP cord-018017-c8myq6bi 527 5 . . . cord-018017-c8myq6bi 527 6 2018 2018 CD cord-018017-c8myq6bi 527 7 ) ) -RRB- cord-018017-c8myq6bi 527 8 . . . cord-018017-c8myq6bi 528 1 These these DT cord-018017-c8myq6bi 528 2 phages phage NNS cord-018017-c8myq6bi 528 3 influence influence VBP cord-018017-c8myq6bi 528 4 bacterial bacterial JJ cord-018017-c8myq6bi 528 5 lifecycles lifecycle NNS cord-018017-c8myq6bi 528 6 and and CC cord-018017-c8myq6bi 528 7 play play VB cord-018017-c8myq6bi 528 8 a a DT cord-018017-c8myq6bi 528 9 role role NN cord-018017-c8myq6bi 528 10 in in IN cord-018017-c8myq6bi 528 11 natural natural JJ cord-018017-c8myq6bi 528 12 energy energy NN cord-018017-c8myq6bi 528 13 and and CC cord-018017-c8myq6bi 528 14 nutrient nutrient NN cord-018017-c8myq6bi 528 15 cycles cycle NNS cord-018017-c8myq6bi 528 16 fundamental fundamental JJ cord-018017-c8myq6bi 528 17 to to IN cord-018017-c8myq6bi 528 18 life life NN cord-018017-c8myq6bi 528 19 on on IN cord-018017-c8myq6bi 528 20 Earth Earth NNP cord-018017-c8myq6bi 528 21 . . . cord-018017-c8myq6bi 529 1 The the DT cord-018017-c8myq6bi 529 2 dynamics dynamic NNS cord-018017-c8myq6bi 529 3 of of IN cord-018017-c8myq6bi 529 4 phage phage NN cord-018017-c8myq6bi 529 5 - - HYPH cord-018017-c8myq6bi 529 6 bacterial bacterial JJ cord-018017-c8myq6bi 529 7 evolution evolution NN cord-018017-c8myq6bi 529 8 drive drive NN cord-018017-c8myq6bi 529 9 changes change NNS cord-018017-c8myq6bi 529 10 in in IN cord-018017-c8myq6bi 529 11 photosynthesis photosynthesis NN cord-018017-c8myq6bi 529 12 , , , cord-018017-c8myq6bi 529 13 phosphate phosphate NN cord-018017-c8myq6bi 529 14 , , , cord-018017-c8myq6bi 529 15 and and CC cord-018017-c8myq6bi 529 16 nitrogen nitrogen NN cord-018017-c8myq6bi 529 17 balance balance NN cord-018017-c8myq6bi 529 18 ( ( -LRB- cord-018017-c8myq6bi 529 19 Breitbart Breitbart NNP cord-018017-c8myq6bi 529 20 2012 2012 CD cord-018017-c8myq6bi 529 21 ) ) -RRB- cord-018017-c8myq6bi 529 22 . . . cord-018017-c8myq6bi 530 1 Human human JJ cord-018017-c8myq6bi 530 2 accidental accidental JJ cord-018017-c8myq6bi 530 3 release release NN cord-018017-c8myq6bi 530 4 of of IN cord-018017-c8myq6bi 530 5 radioactive radioactive JJ cord-018017-c8myq6bi 530 6 waste waste NN cord-018017-c8myq6bi 530 7 ( ( -LRB- cord-018017-c8myq6bi 530 8 discussed discuss VBN cord-018017-c8myq6bi 530 9 in in IN cord-018017-c8myq6bi 530 10 Chap Chap NNP cord-018017-c8myq6bi 530 11 . . . cord-018017-c8myq6bi 530 12 2 2 LS cord-018017-c8myq6bi 530 13 ) ) -RRB- cord-018017-c8myq6bi 530 14 and and CC cord-018017-c8myq6bi 530 15 disposal disposal NN cord-018017-c8myq6bi 530 16 of of IN cord-018017-c8myq6bi 530 17 chemicals chemical NNS cord-018017-c8myq6bi 530 18 including include VBG cord-018017-c8myq6bi 530 19 potent potent JJ cord-018017-c8myq6bi 530 20 antiviral antiviral JJ cord-018017-c8myq6bi 530 21 and and CC cord-018017-c8myq6bi 530 22 antibacterial antibacterial JJ cord-018017-c8myq6bi 530 23 compounds compound NNS cord-018017-c8myq6bi 530 24 ( ( -LRB- cord-018017-c8myq6bi 530 25 discussed discuss VBN cord-018017-c8myq6bi 530 26 in in IN cord-018017-c8myq6bi 530 27 Chap Chap NNP cord-018017-c8myq6bi 530 28 . . . cord-018017-c8myq6bi 531 1 7 7 LS cord-018017-c8myq6bi 531 2 ) ) -RRB- cord-018017-c8myq6bi 531 3 may may MD cord-018017-c8myq6bi 531 4 alter alter VB cord-018017-c8myq6bi 531 5 the the DT cord-018017-c8myq6bi 531 6 eco eco JJ cord-018017-c8myq6bi 531 7 - - HYPH cord-018017-c8myq6bi 531 8 evolutionary evolutionary JJ cord-018017-c8myq6bi 531 9 dynamics dynamic NNS cord-018017-c8myq6bi 531 10 producing produce VBG cord-018017-c8myq6bi 531 11 unanticipated unanticipated JJ cord-018017-c8myq6bi 531 12 environmental environmental JJ cord-018017-c8myq6bi 531 13 consequences consequence NNS cord-018017-c8myq6bi 531 14 . . . cord-018017-c8myq6bi 532 1 The the DT cord-018017-c8myq6bi 532 2 objective objective NN cord-018017-c8myq6bi 532 3 of of IN cord-018017-c8myq6bi 532 4 this this DT cord-018017-c8myq6bi 532 5 chapter chapter NN cord-018017-c8myq6bi 532 6 has have VBZ cord-018017-c8myq6bi 532 7 been be VBN cord-018017-c8myq6bi 532 8 to to TO cord-018017-c8myq6bi 532 9 provide provide VB cord-018017-c8myq6bi 532 10 convincing convincing JJ cord-018017-c8myq6bi 532 11 evidence evidence NN cord-018017-c8myq6bi 532 12 that that IN cord-018017-c8myq6bi 532 13 infectious infectious JJ cord-018017-c8myq6bi 532 14 disease disease NN cord-018017-c8myq6bi 532 15 is be VBZ cord-018017-c8myq6bi 532 16 the the DT cord-018017-c8myq6bi 532 17 most most RBS cord-018017-c8myq6bi 532 18 significant significant JJ cord-018017-c8myq6bi 532 19 threat threat NN cord-018017-c8myq6bi 532 20 to to IN cord-018017-c8myq6bi 532 21 human human JJ cord-018017-c8myq6bi 532 22 health health NN cord-018017-c8myq6bi 532 23 . . . cord-018017-c8myq6bi 533 1 The the DT cord-018017-c8myq6bi 533 2 focus focus NN cord-018017-c8myq6bi 533 3 has have VBZ cord-018017-c8myq6bi 533 4 been be VBN cord-018017-c8myq6bi 533 5 on on IN cord-018017-c8myq6bi 533 6 viral viral JJ cord-018017-c8myq6bi 533 7 infections infection NNS cord-018017-c8myq6bi 533 8 because because IN cord-018017-c8myq6bi 533 9 they -PRON- PRP cord-018017-c8myq6bi 533 10 rely rely VBP cord-018017-c8myq6bi 533 11 on on IN cord-018017-c8myq6bi 533 12 host host NN cord-018017-c8myq6bi 533 13 ribosomes ribosome NNS cord-018017-c8myq6bi 533 14 to to TO cord-018017-c8myq6bi 533 15 produce produce VB cord-018017-c8myq6bi 533 16 their -PRON- PRP$ cord-018017-c8myq6bi 533 17 proteins protein NNS cord-018017-c8myq6bi 533 18 , , , cord-018017-c8myq6bi 533 19 recent recent JJ cord-018017-c8myq6bi 533 20 emerging emerge VBG cord-018017-c8myq6bi 533 21 infections infection NNS cord-018017-c8myq6bi 533 22 have have VBP cord-018017-c8myq6bi 533 23 been be VBN cord-018017-c8myq6bi 533 24 from from IN cord-018017-c8myq6bi 533 25 single single RB cord-018017-c8myq6bi 533 26 - - HYPH cord-018017-c8myq6bi 533 27 stranded strand VBN cord-018017-c8myq6bi 533 28 RNA RNA NNP cord-018017-c8myq6bi 533 29 genome genome NN cord-018017-c8myq6bi 533 30 viruses virus NNS cord-018017-c8myq6bi 533 31 , , , cord-018017-c8myq6bi 533 32 and and CC cord-018017-c8myq6bi 533 33 replication replication NN cord-018017-c8myq6bi 533 34 of of IN cord-018017-c8myq6bi 533 35 RNA RNA NNP cord-018017-c8myq6bi 533 36 viruses virus NNS cord-018017-c8myq6bi 533 37 is be VBZ cord-018017-c8myq6bi 533 38 error error NN cord-018017-c8myq6bi 533 39 prone prone JJ cord-018017-c8myq6bi 533 40 . . . cord-018017-c8myq6bi 534 1 Pandemic pandemic NN cord-018017-c8myq6bi 534 2 infections infection NNS cord-018017-c8myq6bi 534 3 have have VBP cord-018017-c8myq6bi 534 4 accompanied accompany VBN cord-018017-c8myq6bi 534 5 the the DT cord-018017-c8myq6bi 534 6 rise rise NN cord-018017-c8myq6bi 534 7 of of IN cord-018017-c8myq6bi 534 8 human human JJ cord-018017-c8myq6bi 534 9 civilization civilization NN cord-018017-c8myq6bi 534 10 frequently frequently RB cord-018017-c8myq6bi 534 11 re re VBD cord-018017-c8myq6bi 534 12 - - VBG cord-018017-c8myq6bi 534 13 occurring occur VBG cord-018017-c8myq6bi 534 14 leaving leave VBG cord-018017-c8myq6bi 534 15 a a DT cord-018017-c8myq6bi 534 16 lasting last VBG cord-018017-c8myq6bi 534 17 imprint imprint NN cord-018017-c8myq6bi 534 18 on on IN cord-018017-c8myq6bi 534 19 human human JJ cord-018017-c8myq6bi 534 20 history history NN cord-018017-c8myq6bi 534 21 punctuated punctuate VBN cord-018017-c8myq6bi 534 22 by by IN cord-018017-c8myq6bi 534 23 profound profound JJ cord-018017-c8myq6bi 534 24 loss loss NN cord-018017-c8myq6bi 534 25 of of IN cord-018017-c8myq6bi 534 26 life life NN cord-018017-c8myq6bi 534 27 . . . cord-018017-c8myq6bi 535 1 Emerging emerge VBG cord-018017-c8myq6bi 535 2 infections infection NNS cord-018017-c8myq6bi 535 3 become become VBP cord-018017-c8myq6bi 535 4 endemic endemic JJ cord-018017-c8myq6bi 535 5 with with IN cord-018017-c8myq6bi 535 6 an an DT cord-018017-c8myq6bi 535 7 annual annual JJ cord-018017-c8myq6bi 535 8 death death NN cord-018017-c8myq6bi 535 9 toll toll NN cord-018017-c8myq6bi 535 10 . . . cord-018017-c8myq6bi 536 1 Each each DT cord-018017-c8myq6bi 536 2 decade decade NN cord-018017-c8myq6bi 536 3 brings bring VBZ cord-018017-c8myq6bi 536 4 a a DT cord-018017-c8myq6bi 536 5 new new JJ cord-018017-c8myq6bi 536 6 onslaught onslaught NN cord-018017-c8myq6bi 536 7 of of IN cord-018017-c8myq6bi 536 8 emerging emerge VBG cord-018017-c8myq6bi 536 9 infectious infectious JJ cord-018017-c8myq6bi 536 10 agents agent NNS cord-018017-c8myq6bi 536 11 . . . cord-018017-c8myq6bi 537 1 We -PRON- PRP cord-018017-c8myq6bi 537 2 are be VBP cord-018017-c8myq6bi 537 3 surprised surprised JJ cord-018017-c8myq6bi 537 4 again again RB cord-018017-c8myq6bi 537 5 and and CC cord-018017-c8myq6bi 537 6 again again RB cord-018017-c8myq6bi 537 7 but but CC cord-018017-c8myq6bi 537 8 have have VBP cord-018017-c8myq6bi 537 9 never never RB cord-018017-c8myq6bi 537 10 prepared prepare VBN cord-018017-c8myq6bi 537 11 for for IN cord-018017-c8myq6bi 537 12 these these DT cord-018017-c8myq6bi 537 13 inevitable inevitable JJ cord-018017-c8myq6bi 537 14 catastrophies catastrophie NNS cord-018017-c8myq6bi 537 15 . . . cord-018017-c8myq6bi 538 1 The the DT cord-018017-c8myq6bi 538 2 long long JJ cord-018017-c8myq6bi 538 3 - - HYPH cord-018017-c8myq6bi 538 4 term term NN cord-018017-c8myq6bi 538 5 consequences consequence NNS cord-018017-c8myq6bi 538 6 often often RB cord-018017-c8myq6bi 538 7 remain remain VBP cord-018017-c8myq6bi 538 8 unrecognized unrecognized JJ cord-018017-c8myq6bi 538 9 and and CC cord-018017-c8myq6bi 538 10 are be VBP cord-018017-c8myq6bi 538 11 always always RB cord-018017-c8myq6bi 538 12 inconvenient inconvenient JJ cord-018017-c8myq6bi 538 13 such such JJ cord-018017-c8myq6bi 538 14 as as IN cord-018017-c8myq6bi 538 15 cancer cancer NN cord-018017-c8myq6bi 538 16 , , , cord-018017-c8myq6bi 538 17 cardiovascular cardiovascular JJ cord-018017-c8myq6bi 538 18 disease disease NN cord-018017-c8myq6bi 538 19 and and CC cord-018017-c8myq6bi 538 20 immune immune JJ cord-018017-c8myq6bi 538 21 associated associate VBN cord-018017-c8myq6bi 538 22 diseases disease NNS cord-018017-c8myq6bi 538 23 that that WDT cord-018017-c8myq6bi 538 24 threaten threaten VBP cord-018017-c8myq6bi 538 25 our -PRON- PRP$ cord-018017-c8myq6bi 538 26 health health NN cord-018017-c8myq6bi 538 27 . . . cord-018017-c8myq6bi 539 1 Reliance reliance NN cord-018017-c8myq6bi 539 2 on on IN cord-018017-c8myq6bi 539 3 clusters cluster NNS cord-018017-c8myq6bi 539 4 of of IN cord-018017-c8myq6bi 539 5 clinical clinical JJ cord-018017-c8myq6bi 539 6 symptoms symptom NNS cord-018017-c8myq6bi 539 7 in in IN cord-018017-c8myq6bi 539 8 the the DT cord-018017-c8myq6bi 539 9 face face NN cord-018017-c8myq6bi 539 10 of of IN cord-018017-c8myq6bi 539 11 diverse diverse JJ cord-018017-c8myq6bi 539 12 and and CC cord-018017-c8myq6bi 539 13 non non JJ cord-018017-c8myq6bi 539 14 - - JJ cord-018017-c8myq6bi 539 15 descriptive descriptive JJ cord-018017-c8myq6bi 539 16 viral viral JJ cord-018017-c8myq6bi 539 17 infection infection NN cord-018017-c8myq6bi 539 18 symptoms symptom NNS cord-018017-c8myq6bi 539 19 is be VBZ cord-018017-c8myq6bi 539 20 a a DT cord-018017-c8myq6bi 539 21 foolhardy foolhardy JJ cord-018017-c8myq6bi 539 22 form form NN cord-018017-c8myq6bi 539 23 of of IN cord-018017-c8myq6bi 539 24 crisis crisis NN cord-018017-c8myq6bi 539 25 management management NN cord-018017-c8myq6bi 539 26 . . . cord-018017-c8myq6bi 540 1 Infectious infectious JJ cord-018017-c8myq6bi 540 2 disease disease NN cord-018017-c8myq6bi 540 3 will will MD cord-018017-c8myq6bi 540 4 certainly certainly RB cord-018017-c8myq6bi 540 5 continue continue VB cord-018017-c8myq6bi 540 6 to to TO cord-018017-c8myq6bi 540 7 pose pose VB cord-018017-c8myq6bi 540 8 the the DT cord-018017-c8myq6bi 540 9 most most RBS cord-018017-c8myq6bi 540 10 significant significant JJ cord-018017-c8myq6bi 540 11 threat threat NN cord-018017-c8myq6bi 540 12 to to IN cord-018017-c8myq6bi 540 13 human human JJ cord-018017-c8myq6bi 540 14 health health NN cord-018017-c8myq6bi 540 15 in in IN cord-018017-c8myq6bi 540 16 the the DT cord-018017-c8myq6bi 540 17 age age NN cord-018017-c8myq6bi 540 18 to to IN cord-018017-c8myq6bi 540 19 cell cell NN cord-018017-c8myq6bi 540 20 phones phone NNS cord-018017-c8myq6bi 540 21 , , , cord-018017-c8myq6bi 540 22 artificial artificial JJ cord-018017-c8myq6bi 540 23 intelligence intelligence NN cord-018017-c8myq6bi 540 24 , , , cord-018017-c8myq6bi 540 25 and and CC cord-018017-c8myq6bi 540 26 global global JJ cord-018017-c8myq6bi 540 27 commerce commerce NN cord-018017-c8myq6bi 540 28 . . . cord-018017-c8myq6bi 541 1 Rapid rapid JJ cord-018017-c8myq6bi 541 2 replication replication NN cord-018017-c8myq6bi 541 3 of of IN cord-018017-c8myq6bi 541 4 viral viral JJ cord-018017-c8myq6bi 541 5 genomes genome NNS cord-018017-c8myq6bi 541 6 combined combine VBN cord-018017-c8myq6bi 541 7 with with IN cord-018017-c8myq6bi 541 8 low low JJ cord-018017-c8myq6bi 541 9 fidelity fidelity NN cord-018017-c8myq6bi 541 10 polymerases polymerase NNS cord-018017-c8myq6bi 541 11 provide provide VBP cord-018017-c8myq6bi 541 12 the the DT cord-018017-c8myq6bi 541 13 foundation foundation NN cord-018017-c8myq6bi 541 14 for for IN cord-018017-c8myq6bi 541 15 an an DT cord-018017-c8myq6bi 541 16 unending unending JJ cord-018017-c8myq6bi 541 17 source source NN cord-018017-c8myq6bi 541 18 of of IN cord-018017-c8myq6bi 541 19 new new JJ cord-018017-c8myq6bi 541 20 emerging emerge VBG cord-018017-c8myq6bi 541 21 infectious infectious JJ cord-018017-c8myq6bi 541 22 agents agent NNS cord-018017-c8myq6bi 541 23 . . . cord-018017-c8myq6bi 542 1 These these DT cord-018017-c8myq6bi 542 2 traits trait NNS cord-018017-c8myq6bi 542 3 also also RB cord-018017-c8myq6bi 542 4 make make VBP cord-018017-c8myq6bi 542 5 viral viral JJ cord-018017-c8myq6bi 542 6 genomes genome NNS cord-018017-c8myq6bi 542 7 sensitive sensitive JJ cord-018017-c8myq6bi 542 8 to to IN cord-018017-c8myq6bi 542 9 environmental environmental JJ cord-018017-c8myq6bi 542 10 contaminants contaminant NNS cord-018017-c8myq6bi 542 11 in in IN cord-018017-c8myq6bi 542 12 a a DT cord-018017-c8myq6bi 542 13 way way NN cord-018017-c8myq6bi 542 14 that that WDT cord-018017-c8myq6bi 542 15 may may MD cord-018017-c8myq6bi 542 16 expand expand VB cord-018017-c8myq6bi 542 17 probabilities probability NNS cord-018017-c8myq6bi 542 18 for for IN cord-018017-c8myq6bi 542 19 zoonosis zoonosis NN cord-018017-c8myq6bi 542 20 . . . cord-018017-c8myq6bi 543 1 Infectious infectious JJ cord-018017-c8myq6bi 543 2 disease disease NN cord-018017-c8myq6bi 543 3 as as IN cord-018017-c8myq6bi 543 4 part part NN cord-018017-c8myq6bi 543 5 of of IN cord-018017-c8myq6bi 543 6 our -PRON- PRP$ cord-018017-c8myq6bi 543 7 environment environment NN cord-018017-c8myq6bi 543 8 is be VBZ cord-018017-c8myq6bi 543 9 not not RB cord-018017-c8myq6bi 543 10 appreciated appreciate VBN cord-018017-c8myq6bi 543 11 . . . cord-018017-c8myq6bi 544 1 The the DT cord-018017-c8myq6bi 544 2 study study NN cord-018017-c8myq6bi 544 3 of of IN cord-018017-c8myq6bi 544 4 infectious infectious JJ cord-018017-c8myq6bi 544 5 disease disease NN cord-018017-c8myq6bi 544 6 is be VBZ cord-018017-c8myq6bi 544 7 not not RB cord-018017-c8myq6bi 544 8 a a DT cord-018017-c8myq6bi 544 9 part part NN cord-018017-c8myq6bi 544 10 of of IN cord-018017-c8myq6bi 544 11 the the DT cord-018017-c8myq6bi 544 12 curricula curriculum NNS cord-018017-c8myq6bi 544 13 of of IN cord-018017-c8myq6bi 544 14 students student NNS cord-018017-c8myq6bi 544 15 in in IN cord-018017-c8myq6bi 544 16 environmental environmental JJ cord-018017-c8myq6bi 544 17 science science NN cord-018017-c8myq6bi 544 18 / / SYM cord-018017-c8myq6bi 544 19 management management NN cord-018017-c8myq6bi 544 20 . . . cord-018017-c8myq6bi 545 1 Textbooks textbook NNS cord-018017-c8myq6bi 545 2 in in IN cord-018017-c8myq6bi 545 3 in in IN cord-018017-c8myq6bi 545 4 environmental environmental JJ cord-018017-c8myq6bi 545 5 studies study NNS cord-018017-c8myq6bi 545 6 do do VBP cord-018017-c8myq6bi 545 7 not not RB cord-018017-c8myq6bi 545 8 include include VB cord-018017-c8myq6bi 545 9 chapters chapter NNS cord-018017-c8myq6bi 545 10 in in IN cord-018017-c8myq6bi 545 11 infectious infectious JJ cord-018017-c8myq6bi 545 12 disease disease NN cord-018017-c8myq6bi 545 13 . . . cord-018017-c8myq6bi 546 1 The the DT cord-018017-c8myq6bi 546 2 integration integration NN cord-018017-c8myq6bi 546 3 of of IN cord-018017-c8myq6bi 546 4 research research NN cord-018017-c8myq6bi 546 5 at at IN cord-018017-c8myq6bi 546 6 superfund superfund NNP cord-018017-c8myq6bi 546 7 sites site NNS cord-018017-c8myq6bi 546 8 focused focus VBN cord-018017-c8myq6bi 546 9 on on IN cord-018017-c8myq6bi 546 10 chemical chemical JJ cord-018017-c8myq6bi 546 11 contamination contamination NN cord-018017-c8myq6bi 546 12 with with IN cord-018017-c8myq6bi 546 13 infection infection NN cord-018017-c8myq6bi 546 14 and and CC cord-018017-c8myq6bi 546 15 zoonosis zoonosis NN cord-018017-c8myq6bi 546 16 would would MD cord-018017-c8myq6bi 546 17 result result VB cord-018017-c8myq6bi 546 18 in in IN cord-018017-c8myq6bi 546 19 valuable valuable JJ cord-018017-c8myq6bi 546 20 insights insight NNS cord-018017-c8myq6bi 546 21 into into IN cord-018017-c8myq6bi 546 22 threat threat NN cord-018017-c8myq6bi 546 23 analysis analysis NN cord-018017-c8myq6bi 546 24 . . . cord-018017-c8myq6bi 547 1 Viruses virus NNS cord-018017-c8myq6bi 547 2 with with IN cord-018017-c8myq6bi 547 3 RNA RNA NNP cord-018017-c8myq6bi 547 4 genomes genome NNS cord-018017-c8myq6bi 547 5 lack lack VBP cord-018017-c8myq6bi 547 6 sequence sequence NN cord-018017-c8myq6bi 547 7 proofreading proofread VBG cord-018017-c8myq6bi 547 8 quality quality NN cord-018017-c8myq6bi 547 9 control control NN cord-018017-c8myq6bi 547 10 during during IN cord-018017-c8myq6bi 547 11 replication replication NN cord-018017-c8myq6bi 547 12 . . . cord-018017-c8myq6bi 548 1 The the DT cord-018017-c8myq6bi 548 2 cumulative cumulative JJ cord-018017-c8myq6bi 548 3 mutations mutation NNS cord-018017-c8myq6bi 548 4 in in IN cord-018017-c8myq6bi 548 5 their -PRON- PRP$ cord-018017-c8myq6bi 548 6 genomes genome NNS cord-018017-c8myq6bi 548 7 limits limit VBZ cord-018017-c8myq6bi 548 8 the the DT cord-018017-c8myq6bi 548 9 genome genome NN cord-018017-c8myq6bi 548 10 size size NN cord-018017-c8myq6bi 548 11 to to IN cord-018017-c8myq6bi 548 12 under under IN cord-018017-c8myq6bi 548 13 30,000 30,000 CD cord-018017-c8myq6bi 548 14 bases basis NNS cord-018017-c8myq6bi 548 15 . . . cord-018017-c8myq6bi 549 1 Essentially essentially RB cord-018017-c8myq6bi 549 2 , , , cord-018017-c8myq6bi 549 3 a a DT cord-018017-c8myq6bi 549 4 larger large JJR cord-018017-c8myq6bi 549 5 genome genome NN cord-018017-c8myq6bi 549 6 would would MD cord-018017-c8myq6bi 549 7 evolve evolve VB cord-018017-c8myq6bi 549 8 out out IN cord-018017-c8myq6bi 549 9 of of IN cord-018017-c8myq6bi 549 10 existence existence NN cord-018017-c8myq6bi 549 11 , , , cord-018017-c8myq6bi 549 12 so so RB cord-018017-c8myq6bi 549 13 called call VBN cord-018017-c8myq6bi 549 14 catastrophe catastrophe NN cord-018017-c8myq6bi 549 15 evolution evolution NN cord-018017-c8myq6bi 549 16 . . . cord-018017-c8myq6bi 550 1 The the DT cord-018017-c8myq6bi 550 2 limited limited JJ cord-018017-c8myq6bi 550 3 genome genome NN cord-018017-c8myq6bi 550 4 size size NN cord-018017-c8myq6bi 550 5 makes make VBZ cord-018017-c8myq6bi 550 6 these these DT cord-018017-c8myq6bi 550 7 viruses virus NNS cord-018017-c8myq6bi 550 8 exceptionally exceptionally RB cord-018017-c8myq6bi 550 9 resilient resilient JJ cord-018017-c8myq6bi 550 10 to to IN cord-018017-c8myq6bi 550 11 a a DT cord-018017-c8myq6bi 550 12 changing change VBG cord-018017-c8myq6bi 550 13 environment environment NN cord-018017-c8myq6bi 550 14 . . . cord-018017-c8myq6bi 551 1 The the DT cord-018017-c8myq6bi 551 2 virus virus NN cord-018017-c8myq6bi 551 3 must must MD cord-018017-c8myq6bi 551 4 economize economize VB cord-018017-c8myq6bi 551 5 by by IN cord-018017-c8myq6bi 551 6 combining combine VBG cord-018017-c8myq6bi 551 7 functions function NNS cord-018017-c8myq6bi 551 8 . . . cord-018017-c8myq6bi 552 1 This this DT cord-018017-c8myq6bi 552 2 means mean VBZ cord-018017-c8myq6bi 552 3 evolution evolution NN cord-018017-c8myq6bi 552 4 and and CC cord-018017-c8myq6bi 552 5 resilience resilience NN cord-018017-c8myq6bi 552 6 are be VBP cord-018017-c8myq6bi 552 7 the the DT cord-018017-c8myq6bi 552 8 same same JJ cord-018017-c8myq6bi 552 9 thing thing NN cord-018017-c8myq6bi 552 10 in in IN cord-018017-c8myq6bi 552 11 the the DT cord-018017-c8myq6bi 552 12 RNA RNA NNP cord-018017-c8myq6bi 552 13 genome genome NN cord-018017-c8myq6bi 552 14 viruses virus NNS cord-018017-c8myq6bi 552 15 . . . cord-018017-c8myq6bi 553 1 A a DT cord-018017-c8myq6bi 553 2 unique unique JJ cord-018017-c8myq6bi 553 3 insight insight NN cord-018017-c8myq6bi 553 4 is be VBZ cord-018017-c8myq6bi 553 5 that that IN cord-018017-c8myq6bi 553 6 in in IN cord-018017-c8myq6bi 553 7 human human JJ cord-018017-c8myq6bi 553 8 evolution evolution NN cord-018017-c8myq6bi 553 9 is be VBZ cord-018017-c8myq6bi 553 10 restricted restrict VBN cord-018017-c8myq6bi 553 11 to to IN cord-018017-c8myq6bi 553 12 the the DT cord-018017-c8myq6bi 553 13 DNA dna NN cord-018017-c8myq6bi 553 14 genome genome NN cord-018017-c8myq6bi 553 15 and and CC cord-018017-c8myq6bi 553 16 resilience resilience NN cord-018017-c8myq6bi 553 17 limited limit VBN cord-018017-c8myq6bi 553 18 to to IN cord-018017-c8myq6bi 553 19 RNA RNA NNP cord-018017-c8myq6bi 553 20 , , , cord-018017-c8myq6bi 553 21 as as IN cord-018017-c8myq6bi 553 22 it -PRON- PRP cord-018017-c8myq6bi 553 23 is be VBZ cord-018017-c8myq6bi 553 24 in in IN cord-018017-c8myq6bi 553 25 the the DT cord-018017-c8myq6bi 553 26 RNA RNA NNP cord-018017-c8myq6bi 553 27 genome genome NN cord-018017-c8myq6bi 553 28 viruses virus NNS cord-018017-c8myq6bi 553 29 . . . cord-018017-c8myq6bi 554 1 Antisense antisense NN cord-018017-c8myq6bi 554 2 oligonucleotide oligonucleotide RB cord-018017-c8myq6bi 554 3 - - HYPH cord-018017-c8myq6bi 554 4 based base VBN cord-018017-c8myq6bi 554 5 therapy therapy NN cord-018017-c8myq6bi 554 6 for for IN cord-018017-c8myq6bi 554 7 HIV-1 HIV-1 NNP cord-018017-c8myq6bi 554 8 infection infection NN cord-018017-c8myq6bi 554 9 from from IN cord-018017-c8myq6bi 554 10 laboratory laboratory NN cord-018017-c8myq6bi 554 11 to to IN cord-018017-c8myq6bi 554 12 clinical clinical JJ cord-018017-c8myq6bi 554 13 trials trial NNS cord-018017-c8myq6bi 554 14 Oligodeoxynucleotide Oligodeoxynucleotide NNP cord-018017-c8myq6bi 554 15 phosphoramidates phosphoramidate NNS cord-018017-c8myq6bi 554 16 and and CC cord-018017-c8myq6bi 554 17 phosphorothioates phosphorothioate NNS cord-018017-c8myq6bi 554 18 as as IN cord-018017-c8myq6bi 554 19 inhibitors inhibitor NNS cord-018017-c8myq6bi 554 20 of of IN cord-018017-c8myq6bi 554 21 human human JJ cord-018017-c8myq6bi 554 22 immunodeficiency immunodeficiency NN cord-018017-c8myq6bi 554 23 virus virus NN cord-018017-c8myq6bi 555 1 A a DT cord-018017-c8myq6bi 555 2 tribute tribute NN cord-018017-c8myq6bi 555 3 to to IN cord-018017-c8myq6bi 555 4 Sheik Sheik NNP cord-018017-c8myq6bi 555 5 Humarr Humarr NNP cord-018017-c8myq6bi 555 6 Khan Khan NNP cord-018017-c8myq6bi 555 7 and and CC cord-018017-c8myq6bi 555 8 all all PDT cord-018017-c8myq6bi 555 9 the the DT cord-018017-c8myq6bi 555 10 healthcare healthcare NN cord-018017-c8myq6bi 555 11 workers worker NNS cord-018017-c8myq6bi 555 12 in in IN cord-018017-c8myq6bi 555 13 West West NNP cord-018017-c8myq6bi 555 14 Africa Africa NNP cord-018017-c8myq6bi 555 15 who who WP cord-018017-c8myq6bi 555 16 have have VBP cord-018017-c8myq6bi 555 17 sacrificed sacrifice VBN cord-018017-c8myq6bi 555 18 in in IN cord-018017-c8myq6bi 555 19 the the DT cord-018017-c8myq6bi 555 20 fight fight NN cord-018017-c8myq6bi 555 21 against against IN cord-018017-c8myq6bi 555 22 Ebola Ebola NNP cord-018017-c8myq6bi 555 23 virus virus NN cord-018017-c8myq6bi 555 24 disease disease NN cord-018017-c8myq6bi 555 25 : : : cord-018017-c8myq6bi 556 1 mae mae NNP cord-018017-c8myq6bi 557 1 we -PRON- PRP cord-018017-c8myq6bi 557 2 hush hush JJ cord-018017-c8myq6bi 557 3 Inhibition Inhibition NNP cord-018017-c8myq6bi 557 4 of of IN cord-018017-c8myq6bi 557 5 Norovirus Norovirus NNP cord-018017-c8myq6bi 557 6 replication replication NN cord-018017-c8myq6bi 557 7 by by IN cord-018017-c8myq6bi 557 8 Morpholino Morpholino NNP cord-018017-c8myq6bi 557 9 oligomers oligomer NNS cord-018017-c8myq6bi 557 10 targeting target VBG cord-018017-c8myq6bi 557 11 the the DT cord-018017-c8myq6bi 557 12 5'-end 5'-end CD cord-018017-c8myq6bi 557 13 of of IN cord-018017-c8myq6bi 557 14 the the DT cord-018017-c8myq6bi 557 15 genome genome NN cord-018017-c8myq6bi 557 16 Marine marine NN cord-018017-c8myq6bi 557 17 viruses virus NNS cord-018017-c8myq6bi 557 18 : : : cord-018017-c8myq6bi 557 19 truth truth NN cord-018017-c8myq6bi 557 20 or or CC cord-018017-c8myq6bi 557 21 dare dare VB cord-018017-c8myq6bi 557 22 Cancer cancer NN cord-018017-c8myq6bi 557 23 virus virus NN cord-018017-c8myq6bi 557 24 Oseltamivir Oseltamivir NNP cord-018017-c8myq6bi 557 25 - - HYPH cord-018017-c8myq6bi 557 26 resistant resistant JJ cord-018017-c8myq6bi 557 27 2009 2009 CD cord-018017-c8myq6bi 557 28 pandemic pandemic NN cord-018017-c8myq6bi 557 29 influenza influenza NN cord-018017-c8myq6bi 557 30 A A NNP cord-018017-c8myq6bi 557 31 ( ( -LRB- cord-018017-c8myq6bi 557 32 H1N1 H1N1 NNP cord-018017-c8myq6bi 557 33 ) ) -RRB- cord-018017-c8myq6bi 557 34 virus virus NN cord-018017-c8myq6bi 557 35 infection infection NN cord-018017-c8myq6bi 557 36 in in IN cord-018017-c8myq6bi 557 37 two two CD cord-018017-c8myq6bi 557 38 summer summer NN cord-018017-c8myq6bi 557 39 campers camper NNS cord-018017-c8myq6bi 557 40 receiving receive VBG cord-018017-c8myq6bi 557 41 prophylaxis prophylaxis NN cord-018017-c8myq6bi 557 42 - - HYPH cord-018017-c8myq6bi 557 43 North North NNP cord-018017-c8myq6bi 557 44 Carolina Carolina NNP cord-018017-c8myq6bi 557 45 Approved approve VBD cord-018017-c8myq6bi 557 46 antiviral antiviral JJ cord-018017-c8myq6bi 557 47 drugs drug NNS cord-018017-c8myq6bi 557 48 of of IN cord-018017-c8myq6bi 557 49 the the DT cord-018017-c8myq6bi 557 50 past past JJ cord-018017-c8myq6bi 557 51 50 50 CD cord-018017-c8myq6bi 557 52 years year NNS cord-018017-c8myq6bi 558 1 The the DT cord-018017-c8myq6bi 558 2 Eradicatio Eradicatio NNP cord-018017-c8myq6bi 558 3 of of IN cord-018017-c8myq6bi 558 4 smallpox smallpox NN cord-018017-c8myq6bi 558 5 : : : cord-018017-c8myq6bi 558 6 Edward Edward NNP cord-018017-c8myq6bi 558 7 Jenner Jenner NNP cord-018017-c8myq6bi 558 8 and and CC cord-018017-c8myq6bi 558 9 the the DT cord-018017-c8myq6bi 558 10 first first JJ cord-018017-c8myq6bi 558 11 and and CC cord-018017-c8myq6bi 558 12 only only JJ cord-018017-c8myq6bi 558 13 eradication eradication NN cord-018017-c8myq6bi 558 14 of of IN cord-018017-c8myq6bi 558 15 a a DT cord-018017-c8myq6bi 558 16 human human JJ cord-018017-c8myq6bi 558 17 infectious infectious JJ cord-018017-c8myq6bi 558 18 disease disease NN cord-018017-c8myq6bi 558 19 Oseltamivir Oseltamivir NNP cord-018017-c8myq6bi 558 20 resistance resistance NN cord-018017-c8myq6bi 558 21 during during IN cord-018017-c8myq6bi 558 22 treatment treatment NN cord-018017-c8myq6bi 558 23 of of IN cord-018017-c8myq6bi 558 24 influenza influenza NN cord-018017-c8myq6bi 558 25 A a NN cord-018017-c8myq6bi 558 26 ( ( -LRB- cord-018017-c8myq6bi 558 27 H5N1 H5N1 NNP cord-018017-c8myq6bi 558 28 ) ) -RRB- cord-018017-c8myq6bi 558 29 infection infection NN cord-018017-c8myq6bi 559 1 In in IN cord-018017-c8myq6bi 559 2 vitro vitro FW cord-018017-c8myq6bi 559 3 resistance resistance NN cord-018017-c8myq6bi 559 4 and and CC cord-018017-c8myq6bi 559 5 in in IN cord-018017-c8myq6bi 559 6 vivo vivo NNP cord-018017-c8myq6bi 559 7 efficacy efficacy NN cord-018017-c8myq6bi 559 8 of of IN cord-018017-c8myq6bi 559 9 antisense antisense NNP cord-018017-c8myq6bi 559 10 oligomer oligomer NNP cord-018017-c8myq6bi 559 11 against against IN cord-018017-c8myq6bi 559 12 West West NNP cord-018017-c8myq6bi 559 13 Nile Nile NNP cord-018017-c8myq6bi 559 14 virus virus NN cord-018017-c8myq6bi 559 15 Outbreak outbreak NN cord-018017-c8myq6bi 559 16 of of IN cord-018017-c8myq6bi 559 17 antiviral antiviral JJ cord-018017-c8myq6bi 559 18 drug drug NN cord-018017-c8myq6bi 559 19 - - HYPH cord-018017-c8myq6bi 559 20 resistant resistant JJ cord-018017-c8myq6bi 559 21 influenza influenza NN cord-018017-c8myq6bi 559 22 A a DT cord-018017-c8myq6bi 559 23 in in IN cord-018017-c8myq6bi 559 24 long long JJ cord-018017-c8myq6bi 559 25 - - HYPH cord-018017-c8myq6bi 559 26 term term NN cord-018017-c8myq6bi 559 27 care care NN cord-018017-c8myq6bi 559 28 facility facility NN cord-018017-c8myq6bi 560 1 The the DT cord-018017-c8myq6bi 560 2 perpetual perpetual JJ cord-018017-c8myq6bi 560 3 challenge challenge NN cord-018017-c8myq6bi 560 4 of of IN cord-018017-c8myq6bi 560 5 infectious infectious JJ cord-018017-c8myq6bi 560 6 disease disease NN cord-018017-c8myq6bi 560 7 Clonal Clonal NNP cord-018017-c8myq6bi 560 8 integration integration NN cord-018017-c8myq6bi 560 9 of of IN cord-018017-c8myq6bi 560 10 a a DT cord-018017-c8myq6bi 560 11 polyomavirus polyomavirus NNP cord-018017-c8myq6bi 560 12 in in IN cord-018017-c8myq6bi 560 13 human human JJ cord-018017-c8myq6bi 560 14 Merkel Merkel NNP cord-018017-c8myq6bi 560 15 cell cell NN cord-018017-c8myq6bi 560 16 carcinoma carcinoma NN cord-018017-c8myq6bi 560 17 Morpholino Morpholino NNP cord-018017-c8myq6bi 560 18 oligomers oligomer NNS cord-018017-c8myq6bi 560 19 targeting target VBG cord-018017-c8myq6bi 560 20 the the DT cord-018017-c8myq6bi 560 21 PB1 PB1 NNP cord-018017-c8myq6bi 560 22 and and CC cord-018017-c8myq6bi 560 23 NP NP NNP cord-018017-c8myq6bi 560 24 genes gene NNS cord-018017-c8myq6bi 560 25 enhance enhance VBP cord-018017-c8myq6bi 560 26 survival survival NN cord-018017-c8myq6bi 560 27 of of IN cord-018017-c8myq6bi 560 28 mice mouse NNS cord-018017-c8myq6bi 560 29 infected infect VBN cord-018017-c8myq6bi 560 30 with with IN cord-018017-c8myq6bi 560 31 highly highly RB cord-018017-c8myq6bi 560 32 pathogenic pathogenic JJ cord-018017-c8myq6bi 560 33 influenza influenza NN cord-018017-c8myq6bi 560 34 A a DT cord-018017-c8myq6bi 560 35 H7N7 H7N7 NNP cord-018017-c8myq6bi 560 36 virus virus NN cord-018017-c8myq6bi 560 37 Inhibition inhibition NN cord-018017-c8myq6bi 560 38 of of IN cord-018017-c8myq6bi 560 39 multiple multiple JJ cord-018017-c8myq6bi 560 40 subtypes subtype NNS cord-018017-c8myq6bi 560 41 of of IN cord-018017-c8myq6bi 560 42 influenza influenza NN cord-018017-c8myq6bi 560 43 a a DT cord-018017-c8myq6bi 560 44 virus virus NN cord-018017-c8myq6bi 560 45 in in IN cord-018017-c8myq6bi 560 46 cell cell NN cord-018017-c8myq6bi 560 47 cultures culture NNS cord-018017-c8myq6bi 560 48 with with IN cord-018017-c8myq6bi 560 49 morpholino morpholino NNP cord-018017-c8myq6bi 560 50 oligomers oligomers NNPS cord-018017-c8myq6bi 560 51 Safety Safety NNP cord-018017-c8myq6bi 560 52 and and CC cord-018017-c8myq6bi 560 53 pharmacokinetic pharmacokinetic JJ cord-018017-c8myq6bi 560 54 profiles profile NNS cord-018017-c8myq6bi 560 55 of of IN cord-018017-c8myq6bi 560 56 phosphorodiamidate phosphorodiamidate JJ cord-018017-c8myq6bi 560 57 morpholino morpholino NNP cord-018017-c8myq6bi 560 58 oligomers oligomer NNS cord-018017-c8myq6bi 560 59 with with IN cord-018017-c8myq6bi 560 60 activity activity NN cord-018017-c8myq6bi 560 61 against against IN cord-018017-c8myq6bi 560 62 Ebola Ebola NNP cord-018017-c8myq6bi 560 63 virus virus NN cord-018017-c8myq6bi 560 64 and and CC cord-018017-c8myq6bi 560 65 Marburg Marburg NNP cord-018017-c8myq6bi 560 66 virus virus NN cord-018017-c8myq6bi 560 67 : : : cord-018017-c8myq6bi 560 68 results result NNS cord-018017-c8myq6bi 560 69 of of IN cord-018017-c8myq6bi 560 70 two two CD cord-018017-c8myq6bi 560 71 single single JJ cord-018017-c8myq6bi 560 72 ascending ascend VBG cord-018017-c8myq6bi 560 73 dose dose NN cord-018017-c8myq6bi 560 74 studies study NNS cord-018017-c8myq6bi 560 75 Cytomegalovirus Cytomegalovirus NNP cord-018017-c8myq6bi 560 76 infection infection NN cord-018017-c8myq6bi 560 77 and and CC cord-018017-c8myq6bi 560 78 atherosclerosis atherosclerosis NN cord-018017-c8myq6bi 560 79 in in IN cord-018017-c8myq6bi 560 80 candidate candidate NN cord-018017-c8myq6bi 560 81 of of IN cord-018017-c8myq6bi 560 82 coronary coronary JJ cord-018017-c8myq6bi 560 83 artery artery NN cord-018017-c8myq6bi 560 84 bypass bypass NN cord-018017-c8myq6bi 560 85 graft graft NN cord-018017-c8myq6bi 560 86 Inhibition inhibition NN cord-018017-c8myq6bi 560 87 of of IN cord-018017-c8myq6bi 560 88 dengue dengue NN cord-018017-c8myq6bi 560 89 virus virus NN cord-018017-c8myq6bi 560 90 translation translation NN cord-018017-c8myq6bi 560 91 and and CC cord-018017-c8myq6bi 560 92 RNA RNA NNP cord-018017-c8myq6bi 560 93 synthesis synthesis NN cord-018017-c8myq6bi 560 94 by by IN cord-018017-c8myq6bi 560 95 a a DT cord-018017-c8myq6bi 560 96 morpholino morpholino NNP cord-018017-c8myq6bi 560 97 oligomer oligomer NNP cord-018017-c8myq6bi 560 98 targeted target VBN cord-018017-c8myq6bi 560 99 to to IN cord-018017-c8myq6bi 560 100 the the DT cord-018017-c8myq6bi 560 101 terminal terminal JJ cord-018017-c8myq6bi 560 102 3′ 3′ CD cord-018017-c8myq6bi 560 103 stem stem NN cord-018017-c8myq6bi 560 104 - - HYPH cord-018017-c8myq6bi 560 105 loop loop NN cord-018017-c8myq6bi 560 106 structure structure NN cord-018017-c8myq6bi 560 107 Pharmacokinetics Pharmacokinetics NNP cord-018017-c8myq6bi 560 108 of of IN cord-018017-c8myq6bi 560 109 an an DT cord-018017-c8myq6bi 560 110 antisense antisense NN cord-018017-c8myq6bi 560 111 phosphorothioate phosphorothioate VBN cord-018017-c8myq6bi 560 112 oligodeoxynucleotide oligodeoxynucleotide NN cord-018017-c8myq6bi 560 113 against against IN cord-018017-c8myq6bi 560 114 rev rev NNP cord-018017-c8myq6bi 560 115 from from IN cord-018017-c8myq6bi 560 116 human human JJ cord-018017-c8myq6bi 560 117 immunodeficiency immunodeficiency NN cord-018017-c8myq6bi 560 118 virus virus NN cord-018017-c8myq6bi 560 119 type type NN cord-018017-c8myq6bi 560 120 1 1 CD cord-018017-c8myq6bi 560 121 in in IN cord-018017-c8myq6bi 560 122 the the DT cord-018017-c8myq6bi 560 123 adult adult NN cord-018017-c8myq6bi 560 124 male male JJ cord-018017-c8myq6bi 560 125 rat rat NN cord-018017-c8myq6bi 560 126 following follow VBG cord-018017-c8myq6bi 560 127 single single JJ cord-018017-c8myq6bi 560 128 injections injection NNS cord-018017-c8myq6bi 560 129 and and CC cord-018017-c8myq6bi 561 1 continuous continuous JJ cord-018017-c8myq6bi 561 2 infusion infusion NN cord-018017-c8myq6bi 561 3 Phase Phase NNP cord-018017-c8myq6bi 561 4 2a 2a CD cord-018017-c8myq6bi 561 5 study study NN cord-018017-c8myq6bi 561 6 of of IN cord-018017-c8myq6bi 561 7 the the DT cord-018017-c8myq6bi 561 8 CCR5 CCR5 NNP cord-018017-c8myq6bi 561 9 monoclonal monoclonal JJ cord-018017-c8myq6bi 561 10 antibody antibody NN cord-018017-c8myq6bi 561 11 PRO PRO NNP cord-018017-c8myq6bi 561 12 140 140 CD cord-018017-c8myq6bi 561 13 administered administer VBN cord-018017-c8myq6bi 561 14 intravenously intravenously RB cord-018017-c8myq6bi 561 15 to to IN cord-018017-c8myq6bi 561 16 HIV HIV NNP cord-018017-c8myq6bi 561 17 - - HYPH cord-018017-c8myq6bi 561 18 infected infect VBN cord-018017-c8myq6bi 561 19 adults adult NNS cord-018017-c8myq6bi 561 20 Anti Anti NNP cord-018017-c8myq6bi 561 21 - - NNP cord-018017-c8myq6bi 561 22 HIV-1 HIV-1 NNP cord-018017-c8myq6bi 561 23 activity activity NN cord-018017-c8myq6bi 561 24 of of IN cord-018017-c8myq6bi 561 25 weekly weekly JJ cord-018017-c8myq6bi 561 26 or or CC cord-018017-c8myq6bi 561 27 biweekly biweekly JJ cord-018017-c8myq6bi 561 28 treatment treatment NN cord-018017-c8myq6bi 561 29 with with IN cord-018017-c8myq6bi 561 30 subcutaneous subcutaneous JJ cord-018017-c8myq6bi 561 31 PRO PRO NNP cord-018017-c8myq6bi 561 32 140 140 CD cord-018017-c8myq6bi 561 33 , , , cord-018017-c8myq6bi 561 34 a a DT cord-018017-c8myq6bi 561 35 CCR5 CCR5 NNP cord-018017-c8myq6bi 561 36 monoclonal monoclonal JJ cord-018017-c8myq6bi 561 37 antibody antibody NN cord-018017-c8myq6bi 561 38 Oseltamivir Oseltamivir NNP cord-018017-c8myq6bi 561 39 for for IN cord-018017-c8myq6bi 561 40 influenza influenza NN cord-018017-c8myq6bi 561 41 in in IN cord-018017-c8myq6bi 561 42 adults adult NNS cord-018017-c8myq6bi 561 43 and and CC cord-018017-c8myq6bi 561 44 children child NNS cord-018017-c8myq6bi 561 45 : : : cord-018017-c8myq6bi 561 46 systemic systemic JJ cord-018017-c8myq6bi 561 47 review review NN cord-018017-c8myq6bi 561 48 of of IN cord-018017-c8myq6bi 561 49 clinical clinical JJ cord-018017-c8myq6bi 561 50 study study NN cord-018017-c8myq6bi 561 51 reports report NNS cord-018017-c8myq6bi 561 52 and and CC cord-018017-c8myq6bi 561 53 summary summary NN cord-018017-c8myq6bi 561 54 of of IN cord-018017-c8myq6bi 561 55 regulatory regulatory JJ cord-018017-c8myq6bi 561 56 comments comment NNS cord-018017-c8myq6bi 561 57 Passive passive JJ cord-018017-c8myq6bi 561 58 immunity immunity NN cord-018017-c8myq6bi 561 59 in in IN cord-018017-c8myq6bi 561 60 prevention prevention NN cord-018017-c8myq6bi 561 61 and and CC cord-018017-c8myq6bi 561 62 treatment treatment NN cord-018017-c8myq6bi 561 63 of of IN cord-018017-c8myq6bi 561 64 infectious infectious JJ cord-018017-c8myq6bi 561 65 diseases disease NNS cord-018017-c8myq6bi 562 1 Viral viral JJ cord-018017-c8myq6bi 562 2 diversity diversity NN cord-018017-c8myq6bi 562 3 and and CC cord-018017-c8myq6bi 562 4 clonal clonal JJ cord-018017-c8myq6bi 562 5 evolution evolution NN cord-018017-c8myq6bi 562 6 from from IN cord-018017-c8myq6bi 562 7 unphased unphased JJ cord-018017-c8myq6bi 562 8 genomic genomic JJ cord-018017-c8myq6bi 562 9 data datum NNS cord-018017-c8myq6bi 562 10 Ecology ecology NN cord-018017-c8myq6bi 562 11 of of IN cord-018017-c8myq6bi 562 12 viruses virus NNS cord-018017-c8myq6bi 562 13 in in IN cord-018017-c8myq6bi 562 14 soils soil NNS cord-018017-c8myq6bi 562 15 : : : cord-018017-c8myq6bi 562 16 past past NN cord-018017-c8myq6bi 562 17 , , , cord-018017-c8myq6bi 562 18 present present JJ cord-018017-c8myq6bi 562 19 and and CC cord-018017-c8myq6bi 562 20 future future JJ cord-018017-c8myq6bi 562 21 perspectives perspective NNS cord-018017-c8myq6bi 562 22 Inhibition inhibition NN cord-018017-c8myq6bi 562 23 of of IN cord-018017-c8myq6bi 562 24 dengue dengue NN cord-018017-c8myq6bi 562 25 virus virus NN cord-018017-c8myq6bi 562 26 serotypes serotype NNS cord-018017-c8myq6bi 562 27 1 1 CD cord-018017-c8myq6bi 562 28 to to IN cord-018017-c8myq6bi 562 29 4 4 CD cord-018017-c8myq6bi 562 30 in in IN cord-018017-c8myq6bi 562 31 cell cell NN cord-018017-c8myq6bi 562 32 culture culture NN cord-018017-c8myq6bi 562 33 with with IN cord-018017-c8myq6bi 562 34 Morpholino Morpholino NNP cord-018017-c8myq6bi 562 35 oligomers oligomer NNS cord-018017-c8myq6bi 562 36 Inhibition inhibition NN cord-018017-c8myq6bi 562 37 of of IN cord-018017-c8myq6bi 562 38 respiratory respiratory JJ cord-018017-c8myq6bi 562 39 Syncitial Syncitial NNP cord-018017-c8myq6bi 562 40 virus virus NN cord-018017-c8myq6bi 562 41 infections infection NNS cord-018017-c8myq6bi 562 42 in in IN cord-018017-c8myq6bi 562 43 cell cell NN cord-018017-c8myq6bi 562 44 cultures culture NNS cord-018017-c8myq6bi 562 45 and and CC cord-018017-c8myq6bi 562 46 in in IN cord-018017-c8myq6bi 562 47 mice mouse NNS cord-018017-c8myq6bi 562 48 with with IN cord-018017-c8myq6bi 562 49 morpholino morpholino NNP cord-018017-c8myq6bi 562 50 oligomers oligomer NNS cord-018017-c8myq6bi 562 51 Dissemination Dissemination NNP cord-018017-c8myq6bi 562 52 , , , cord-018017-c8myq6bi 562 53 divergence divergence NN cord-018017-c8myq6bi 562 54 and and CC cord-018017-c8myq6bi 562 55 establishment establishment NN cord-018017-c8myq6bi 562 56 of of IN cord-018017-c8myq6bi 562 57 H7N9 H7N9 NNP cord-018017-c8myq6bi 562 58 influenza influenza NN cord-018017-c8myq6bi 562 59 viruses virus NNS cord-018017-c8myq6bi 562 60 in in IN cord-018017-c8myq6bi 562 61 China China NNP cord-018017-c8myq6bi 562 62 Health Health NNP cord-018017-c8myq6bi 562 63 impact impact NN cord-018017-c8myq6bi 562 64 of of IN cord-018017-c8myq6bi 562 65 globalization globalization NN cord-018017-c8myq6bi 562 66 : : : cord-018017-c8myq6bi 562 67 towards towards IN cord-018017-c8myq6bi 562 68 global global JJ cord-018017-c8myq6bi 562 69 governance governance NN cord-018017-c8myq6bi 562 70 Inhibition inhibition NN cord-018017-c8myq6bi 562 71 of of IN cord-018017-c8myq6bi 562 72 influenza influenza NN cord-018017-c8myq6bi 562 73 A a DT cord-018017-c8myq6bi 562 74 H3N8 H3N8 NNP cord-018017-c8myq6bi 562 75 virus virus NN cord-018017-c8myq6bi 562 76 infections infection NNS cord-018017-c8myq6bi 562 77 in in IN cord-018017-c8myq6bi 562 78 mice mouse NNS cord-018017-c8myq6bi 562 79 by by IN cord-018017-c8myq6bi 562 80 morpholino morpholino NNP cord-018017-c8myq6bi 562 81 oligomers oligomer NNS cord-018017-c8myq6bi 562 82 Isolation isolation NN cord-018017-c8myq6bi 562 83 and and CC cord-018017-c8myq6bi 562 84 characterization characterization NN cord-018017-c8myq6bi 562 85 of of IN cord-018017-c8myq6bi 562 86 a a DT cord-018017-c8myq6bi 562 87 new new JJ cord-018017-c8myq6bi 562 88 Vesivirus Vesivirus NNP cord-018017-c8myq6bi 562 89 from from IN cord-018017-c8myq6bi 562 90 rabbits rabbit NNS cord-018017-c8myq6bi 563 1 Phosphorothioate phosphorothioate JJ cord-018017-c8myq6bi 563 2 analogs analog NNS cord-018017-c8myq6bi 563 3 of of IN cord-018017-c8myq6bi 563 4 oligodeoxyribonucleotides oligodeoxyribonucleotide NNS cord-018017-c8myq6bi 563 5 : : : cord-018017-c8myq6bi 563 6 inhibitors inhibitor NNS cord-018017-c8myq6bi 563 7 of of IN cord-018017-c8myq6bi 563 8 replication replication NN cord-018017-c8myq6bi 563 9 and and CC cord-018017-c8myq6bi 563 10 cytopathic cytopathic JJ cord-018017-c8myq6bi 563 11 effects effect NNS cord-018017-c8myq6bi 563 12 of of IN cord-018017-c8myq6bi 563 13 human human JJ cord-018017-c8myq6bi 563 14 immunodeficiency immunodeficiency NN cord-018017-c8myq6bi 563 15 virus virus NN cord-018017-c8myq6bi 563 16 Endogenous endogenous JJ cord-018017-c8myq6bi 563 17 retroviruses retrovirus NNS cord-018017-c8myq6bi 563 18 : : : cord-018017-c8myq6bi 563 19 with with IN cord-018017-c8myq6bi 563 20 us -PRON- PRP cord-018017-c8myq6bi 563 21 and and CC cord-018017-c8myq6bi 563 22 against against IN cord-018017-c8myq6bi 563 23 us -PRON- PRP cord-018017-c8myq6bi 564 1 The the DT cord-018017-c8myq6bi 564 2 value value NN cord-018017-c8myq6bi 564 3 of of IN cord-018017-c8myq6bi 564 4 neuraminidase neuraminidase FW cord-018017-c8myq6bi 564 5 inhibitors inhibitor NNS cord-018017-c8myq6bi 564 6 for for IN cord-018017-c8myq6bi 564 7 the the DT cord-018017-c8myq6bi 564 8 prevention prevention NN cord-018017-c8myq6bi 564 9 and and CC cord-018017-c8myq6bi 564 10 treatment treatment NN cord-018017-c8myq6bi 564 11 of of IN cord-018017-c8myq6bi 564 12 seasonal seasonal JJ cord-018017-c8myq6bi 564 13 influenza influenza NN cord-018017-c8myq6bi 564 14 : : : cord-018017-c8myq6bi 564 15 a a DT cord-018017-c8myq6bi 564 16 systematic systematic JJ cord-018017-c8myq6bi 564 17 review review NN cord-018017-c8myq6bi 564 18 of of IN cord-018017-c8myq6bi 564 19 systematic systematic JJ cord-018017-c8myq6bi 564 20 reviews review NNS cord-018017-c8myq6bi 564 21 Antisense Antisense NNP cord-018017-c8myq6bi 564 22 morpholino morpholino VBP cord-018017-c8myq6bi 564 23 oligomers oligomer NNS cord-018017-c8myq6bi 564 24 directed direct VBN cord-018017-c8myq6bi 564 25 against against IN cord-018017-c8myq6bi 564 26 the the DT cord-018017-c8myq6bi 564 27 5'-end 5'-end CD cord-018017-c8myq6bi 564 28 of of IN cord-018017-c8myq6bi 565 1 the the DT cord-018017-c8myq6bi 565 2 genome genome NN cord-018017-c8myq6bi 565 3 inhibit inhibit VBP cord-018017-c8myq6bi 565 4 coronavirus coronavirus NN cord-018017-c8myq6bi 565 5 proliferation proliferation NN cord-018017-c8myq6bi 565 6 and and CC cord-018017-c8myq6bi 565 7 growth growth NN cord-018017-c8myq6bi 565 8 Inhibition inhibition NN cord-018017-c8myq6bi 565 9 , , , cord-018017-c8myq6bi 565 10 escape escape NN cord-018017-c8myq6bi 565 11 and and CC cord-018017-c8myq6bi 565 12 attenuation attenuation NN cord-018017-c8myq6bi 565 13 of of IN cord-018017-c8myq6bi 565 14 SARS SARS NNP cord-018017-c8myq6bi 565 15 coronavirus coronavirus NN cord-018017-c8myq6bi 565 16 treated treat VBN cord-018017-c8myq6bi 565 17 with with IN cord-018017-c8myq6bi 565 18 antisense antisense NN cord-018017-c8myq6bi 565 19 morpholino morpholino NNP cord-018017-c8myq6bi 565 20 oligomers oligomer NNS cord-018017-c8myq6bi 566 1 Inactivating inactivate VBG cord-018017-c8myq6bi 566 2 mutations mutation NNS cord-018017-c8myq6bi 566 3 in in IN cord-018017-c8myq6bi 566 4 an an DT cord-018017-c8myq6bi 566 5 SH2 SH2 NNP cord-018017-c8myq6bi 566 6 domain domain NN cord-018017-c8myq6bi 566 7 - - HYPH cord-018017-c8myq6bi 566 8 encoding encode VBG cord-018017-c8myq6bi 566 9 gene gene NN cord-018017-c8myq6bi 566 10 in in IN cord-018017-c8myq6bi 566 11 X x NN cord-018017-c8myq6bi 566 12 - - HYPH cord-018017-c8myq6bi 566 13 linked link VBN cord-018017-c8myq6bi 566 14 lymphoproliferative lymphoproliferative JJ cord-018017-c8myq6bi 566 15 syndrome syndrome NN cord-018017-c8myq6bi 566 16 Inhibition Inhibition NNP cord-018017-c8myq6bi 566 17 of of IN cord-018017-c8myq6bi 566 18 alphavirus alphavirus NNP cord-018017-c8myq6bi 566 19 infection infection NN cord-018017-c8myq6bi 566 20 in in IN cord-018017-c8myq6bi 566 21 cell cell NN cord-018017-c8myq6bi 566 22 culture culture NN cord-018017-c8myq6bi 566 23 and and CC cord-018017-c8myq6bi 566 24 in in IN cord-018017-c8myq6bi 566 25 mice mouse NNS cord-018017-c8myq6bi 566 26 with with IN cord-018017-c8myq6bi 566 27 antisense antisense NN cord-018017-c8myq6bi 566 28 morpholino morpholino NNP cord-018017-c8myq6bi 567 1 oliogmers oliogmers NNP cord-018017-c8myq6bi 567 2 Immunological immunological JJ cord-018017-c8myq6bi 567 3 disorders disorder NNS cord-018017-c8myq6bi 567 4 and and CC cord-018017-c8myq6bi 567 5 malignancies malignancy NNS cord-018017-c8myq6bi 567 6 in in IN cord-018017-c8myq6bi 567 7 five five CD cord-018017-c8myq6bi 567 8 young young JJ cord-018017-c8myq6bi 567 9 brothers brother NNS cord-018017-c8myq6bi 567 10 Spillover Spillover NNP cord-018017-c8myq6bi 567 11 animal animal NN cord-018017-c8myq6bi 567 12 infections infection NNS cord-018017-c8myq6bi 567 13 and and CC cord-018017-c8myq6bi 567 14 the the DT cord-018017-c8myq6bi 567 15 next next JJ cord-018017-c8myq6bi 567 16 human human JJ cord-018017-c8myq6bi 567 17 pandemic pandemic NN cord-018017-c8myq6bi 567 18 Deposition deposition NN cord-018017-c8myq6bi 567 19 rates rate NNS cord-018017-c8myq6bi 567 20 of of IN cord-018017-c8myq6bi 567 21 viruses virus NNS cord-018017-c8myq6bi 567 22 and and CC cord-018017-c8myq6bi 567 23 bacteria bacteria NNS cord-018017-c8myq6bi 567 24 above above IN cord-018017-c8myq6bi 567 25 the the DT cord-018017-c8myq6bi 567 26 atmospheric atmospheric JJ cord-018017-c8myq6bi 567 27 boundary boundary NN cord-018017-c8myq6bi 567 28 layer layer NN cord-018017-c8myq6bi 568 1 A a DT cord-018017-c8myq6bi 568 2 prospective prospective JJ cord-018017-c8myq6bi 568 3 monitoring monitoring NN cord-018017-c8myq6bi 568 4 study study NN cord-018017-c8myq6bi 568 5 of of IN cord-018017-c8myq6bi 568 6 cytomegalovirus cytomegalovirus JJ cord-018017-c8myq6bi 568 7 infection infection NN cord-018017-c8myq6bi 568 8 in in IN cord-018017-c8myq6bi 568 9 nonimmunosuppressed nonimmunosuppressed JJ cord-018017-c8myq6bi 568 10 critical critical JJ cord-018017-c8myq6bi 568 11 heart heart NN cord-018017-c8myq6bi 568 12 surgery surgery NN cord-018017-c8myq6bi 568 13 patients patient NNS cord-018017-c8myq6bi 568 14 Inhibition Inhibition NNP cord-018017-c8myq6bi 568 15 of of IN cord-018017-c8myq6bi 568 16 acquired acquire VBN cord-018017-c8myq6bi 568 17 immunodeficiency immunodeficiency NN cord-018017-c8myq6bi 568 18 syndrome syndrome NN cord-018017-c8myq6bi 568 19 virus virus NN cord-018017-c8myq6bi 568 20 by by IN cord-018017-c8myq6bi 568 21 oligonucleotide oligonucleotide JJ cord-018017-c8myq6bi 568 22 methylphosphonates methylphosphonate NNS cord-018017-c8myq6bi 569 1 Lymphocytic lymphocytic JJ cord-018017-c8myq6bi 569 2 Choriomeningitis Choriomeningitis NNP cord-018017-c8myq6bi 569 3 virus virus NN cord-018017-c8myq6bi 569 4 infection infection NN cord-018017-c8myq6bi 569 5 in in IN cord-018017-c8myq6bi 569 6 FVB FVB NNP cord-018017-c8myq6bi 569 7 mouse mouse NN cord-018017-c8myq6bi 569 8 produces produce VBZ cord-018017-c8myq6bi 569 9 hemorrhagic hemorrhagic JJ cord-018017-c8myq6bi 569 10 disease disease NN cord-018017-c8myq6bi 569 11 Ancient ancient JJ cord-018017-c8myq6bi 569 12 Athenian athenian JJ cord-018017-c8myq6bi 569 13 plague plague NN cord-018017-c8myq6bi 569 14 proves prove VBZ cord-018017-c8myq6bi 569 15 to to TO cord-018017-c8myq6bi 569 16 be be VB cord-018017-c8myq6bi 569 17 typhoid typhoid JJ cord-018017-c8myq6bi 569 18 Inhibition inhibition NN cord-018017-c8myq6bi 569 19 of of IN cord-018017-c8myq6bi 569 20 Measles Measles NNP cord-018017-c8myq6bi 569 21 virus virus NN cord-018017-c8myq6bi 569 22 infection infection NN cord-018017-c8myq6bi 569 23 in in IN cord-018017-c8myq6bi 569 24 cell cell NN cord-018017-c8myq6bi 569 25 cultures culture NNS cord-018017-c8myq6bi 569 26 by by IN cord-018017-c8myq6bi 569 27 peptide peptide NN cord-018017-c8myq6bi 569 28 - - HYPH cord-018017-c8myq6bi 569 29 conjugated conjugate VBN cord-018017-c8myq6bi 569 30 Morpholino Morpholino NNP cord-018017-c8myq6bi 569 31 oligomers oligomer NNS cord-018017-c8myq6bi 570 1 Vesivirus Vesivirus NNP cord-018017-c8myq6bi 570 2 viremia viremia NN cord-018017-c8myq6bi 570 3 and and CC cord-018017-c8myq6bi 570 4 Seroprevalence Seroprevalence NNP cord-018017-c8myq6bi 570 5 in in IN cord-018017-c8myq6bi 570 6 humans human NNS cord-018017-c8myq6bi 570 7 Virus Virus NNP cord-018017-c8myq6bi 570 8 specific specific JJ cord-018017-c8myq6bi 570 9 antiviral antiviral JJ cord-018017-c8myq6bi 570 10 therapy therapy NN cord-018017-c8myq6bi 570 11 for for IN cord-018017-c8myq6bi 570 12 controlling control VBG cord-018017-c8myq6bi 570 13 severe severe JJ cord-018017-c8myq6bi 570 14 and and CC cord-018017-c8myq6bi 570 15 fatal fatal JJ cord-018017-c8myq6bi 570 16 outbreaks outbreak NNS cord-018017-c8myq6bi 570 17 of of IN cord-018017-c8myq6bi 570 18 feline feline JJ cord-018017-c8myq6bi 570 19 Calicivirus Calicivirus NNP cord-018017-c8myq6bi 570 20 infection infection NN cord-018017-c8myq6bi 570 21 Chimpanzee Chimpanzee NNP cord-018017-c8myq6bi 570 22 adenovirus adenovirus NN cord-018017-c8myq6bi 570 23 vaccine vaccine NN cord-018017-c8myq6bi 570 24 generates generate VBZ cord-018017-c8myq6bi 570 25 acute acute JJ cord-018017-c8myq6bi 570 26 and and CC cord-018017-c8myq6bi 570 27 durable durable JJ cord-018017-c8myq6bi 570 28 protective protective JJ cord-018017-c8myq6bi 570 29 immunity immunity NN cord-018017-c8myq6bi 570 30 against against IN cord-018017-c8myq6bi 570 31 ebolavirus ebolavirus NN cord-018017-c8myq6bi 570 32 challenge challenge NN cord-018017-c8myq6bi 570 33 Inhibition inhibition NN cord-018017-c8myq6bi 570 34 of of IN cord-018017-c8myq6bi 570 35 Vesivirus Vesivirus NNP cord-018017-c8myq6bi 570 36 infetions infetion NNS cord-018017-c8myq6bi 570 37 in in IN cord-018017-c8myq6bi 570 38 mammalian mammalian JJ cord-018017-c8myq6bi 570 39 tissue tissue NN cord-018017-c8myq6bi 570 40 culture culture NN cord-018017-c8myq6bi 570 41 with with IN cord-018017-c8myq6bi 570 42 antisense antisense NN cord-018017-c8myq6bi 570 43 morpholino morpholino NNP cord-018017-c8myq6bi 570 44 oligomers oligomer NNS cord-018017-c8myq6bi 570 45 Inhibition Inhibition NNP cord-018017-c8myq6bi 570 46 of of IN cord-018017-c8myq6bi 570 47 Rous rous JJ cord-018017-c8myq6bi 570 48 sarcoma sarcoma NN cord-018017-c8myq6bi 570 49 viral viral JJ cord-018017-c8myq6bi 570 50 RNA RNA NNP cord-018017-c8myq6bi 570 51 translation translation NN cord-018017-c8myq6bi 570 52 by by IN cord-018017-c8myq6bi 570 53 a a DT cord-018017-c8myq6bi 570 54 specific specific JJ cord-018017-c8myq6bi 570 55 oligodeoxynucleotide oligodeoxynucleotide JJ cord-018017-c8myq6bi 570 56 Inhibition inhibition NN cord-018017-c8myq6bi 570 57 of of IN cord-018017-c8myq6bi 570 58 multiple multiple JJ cord-018017-c8myq6bi 570 59 species specie NNS cord-018017-c8myq6bi 570 60 of of IN cord-018017-c8myq6bi 570 61 picornavirus picornavirus NN cord-018017-c8myq6bi 570 62 using use VBG cord-018017-c8myq6bi 570 63 a a DT cord-018017-c8myq6bi 570 64 morpholino morpholino NNP cord-018017-c8myq6bi 570 65 oligomer oligomer NNP cord-018017-c8myq6bi 570 66 targeting target VBG cord-018017-c8myq6bi 570 67 highly highly RB cord-018017-c8myq6bi 570 68 conserved conserve VBN cord-018017-c8myq6bi 570 69 IRES ires JJ cord-018017-c8myq6bi 570 70 sequence sequence NN cord-018017-c8myq6bi 570 71 Increased increase VBD cord-018017-c8myq6bi 570 72 risk risk NN cord-018017-c8myq6bi 570 73 of of IN cord-018017-c8myq6bi 570 74 hepatocellular hepatocellular JJ cord-018017-c8myq6bi 570 75 carcinoma carcinoma NN cord-018017-c8myq6bi 570 76 in in IN cord-018017-c8myq6bi 570 77 male male JJ cord-018017-c8myq6bi 570 78 hepatiis hepatiis NN cord-018017-c8myq6bi 570 79 B B NNP cord-018017-c8myq6bi 570 80 surface surface NN cord-018017-c8myq6bi 570 81 antigen antigen NN cord-018017-c8myq6bi 570 82 carriers carrier NNS cord-018017-c8myq6bi 570 83 with with IN cord-018017-c8myq6bi 570 84 chronic chronic JJ cord-018017-c8myq6bi 570 85 hepatitis hepatitis NN cord-018017-c8myq6bi 570 86 who who WP cord-018017-c8myq6bi 570 87 have have VBP cord-018017-c8myq6bi 570 88 detectable detectable JJ cord-018017-c8myq6bi 570 89 aflatoxin aflatoxin NN cord-018017-c8myq6bi 570 90 metabolite metabolite NN cord-018017-c8myq6bi 570 91 M1 M1 NNP cord-018017-c8myq6bi 570 92 Viruses Viruses NNPS cord-018017-c8myq6bi 570 93 in in IN cord-018017-c8myq6bi 570 94 the the DT cord-018017-c8myq6bi 570 95 sea sea NN cord-018017-c8myq6bi 570 96 Chemical Chemical NNP cord-018017-c8myq6bi 570 97 modifications modification NNS cord-018017-c8myq6bi 570 98 to to IN cord-018017-c8myq6bi 570 99 phosphorodiamidate phosphorodiamidate NNP cord-018017-c8myq6bi 570 100 Morpholino Morpholino NNP cord-018017-c8myq6bi 570 101 oligomer oligomer NNP cord-018017-c8myq6bi 570 102 antisense antisense NN cord-018017-c8myq6bi 570 103 molecules molecule NNS cord-018017-c8myq6bi 570 104 targeting target VBG cord-018017-c8myq6bi 570 105 VP24 VP24 NNP cord-018017-c8myq6bi 570 106 modify modify VB cord-018017-c8myq6bi 570 107 their -PRON- PRP$ cord-018017-c8myq6bi 570 108 efficacy efficacy NN cord-018017-c8myq6bi 570 109 against against IN cord-018017-c8myq6bi 570 110 Ebola Ebola NNP cord-018017-c8myq6bi 570 111 virus virus NN cord-018017-c8myq6bi 570 112 infection infection NN cord-018017-c8myq6bi 570 113 Use use NN cord-018017-c8myq6bi 570 114 of of IN cord-018017-c8myq6bi 570 115 ChAd3-EBO ChAd3-EBO NNP cord-018017-c8myq6bi 570 116 - - HYPH cord-018017-c8myq6bi 570 117 Z Z NNP cord-018017-c8myq6bi 570 118 Ebola Ebola NNP cord-018017-c8myq6bi 570 119 virus virus NN cord-018017-c8myq6bi 570 120 vaccine vaccine NN cord-018017-c8myq6bi 570 121 in in IN cord-018017-c8myq6bi 570 122 Malian malian JJ cord-018017-c8myq6bi 570 123 adults adult NNS cord-018017-c8myq6bi 570 124 with with IN cord-018017-c8myq6bi 570 125 MVA MVA NNP cord-018017-c8myq6bi 570 126 - - HYPH cord-018017-c8myq6bi 570 127 BN BN NNP cord-018017-c8myq6bi 570 128 - - HYPH cord-018017-c8myq6bi 570 129 Filo Filo NNP cord-018017-c8myq6bi 570 130 : : : cord-018017-c8myq6bi 570 131 a a DT cord-018017-c8myq6bi 570 132 phase phase NN cord-018017-c8myq6bi 570 133 I -PRON- PRP cord-018017-c8myq6bi 570 134 , , , cord-018017-c8myq6bi 570 135 single single JJ cord-018017-c8myq6bi 570 136 - - HYPH cord-018017-c8myq6bi 570 137 blind blind JJ cord-018017-c8myq6bi 570 138 , , , cord-018017-c8myq6bi 570 139 randomized randomized JJ cord-018017-c8myq6bi 570 140 trial trial NN cord-018017-c8myq6bi 570 141 , , , cord-018017-c8myq6bi 570 142 a a DT cord-018017-c8myq6bi 570 143 phase phase NN cord-018017-c8myq6bi 570 144 1b 1b CD cord-018017-c8myq6bi 570 145 , , , cord-018017-c8myq6bi 570 146 open open JJ cord-018017-c8myq6bi 570 147 label label NN cord-018017-c8myq6bi 570 148 and and CC cord-018017-c8myq6bi 570 149 double double JJ cord-018017-c8myq6bi 570 150 blind blind JJ cord-018017-c8myq6bi 570 151 , , , cord-018017-c8myq6bi 570 152 doseescallation doseescallation NN cord-018017-c8myq6bi 570 153 trial trial NN cord-018017-c8myq6bi 570 154 , , , cord-018017-c8myq6bi 570 155 and and CC cord-018017-c8myq6bi 570 156 a a DT cord-018017-c8myq6bi 570 157 nested nest VBN cord-018017-c8myq6bi 570 158 , , , cord-018017-c8myq6bi 570 159 randomized randomized JJ cord-018017-c8myq6bi 570 160 , , , cord-018017-c8myq6bi 570 161 double double JJ cord-018017-c8myq6bi 570 162 - - HYPH cord-018017-c8myq6bi 570 163 blind blind JJ cord-018017-c8myq6bi 570 164 , , , cord-018017-c8myq6bi 570 165 placebo placebo NN cord-018017-c8myq6bi 570 166 - - HYPH cord-018017-c8myq6bi 570 167 controlled control VBN cord-018017-c8myq6bi 570 168 trial trial NN cord-018017-c8myq6bi 570 169 Inhibition inhibition NN cord-018017-c8myq6bi 570 170 of of IN cord-018017-c8myq6bi 570 171 foot foot NN cord-018017-c8myq6bi 570 172 - - HYPH cord-018017-c8myq6bi 570 173 and and CC cord-018017-c8myq6bi 570 174 - - HYPH cord-018017-c8myq6bi 570 175 mouth mouth NN cord-018017-c8myq6bi 570 176 disease disease NN cord-018017-c8myq6bi 570 177 virus virus NN cord-018017-c8myq6bi 570 178 in in IN cord-018017-c8myq6bi 570 179 cell cell NN cord-018017-c8myq6bi 570 180 cultures culture NNS cord-018017-c8myq6bi 570 181 with with IN cord-018017-c8myq6bi 570 182 antisense antisense NN cord-018017-c8myq6bi 570 183 morpholino morpholino NNP cord-018017-c8myq6bi 570 184 oligomers oligomer NNS cord-018017-c8myq6bi 570 185 Antiviral antiviral JJ cord-018017-c8myq6bi 570 186 activity activity NN cord-018017-c8myq6bi 570 187 of of IN cord-018017-c8myq6bi 570 188 morpholino morpholino NNP cord-018017-c8myq6bi 570 189 oligomers oligomer NNS cord-018017-c8myq6bi 570 190 designed design VBN cord-018017-c8myq6bi 570 191 to to TO cord-018017-c8myq6bi 570 192 block block VB cord-018017-c8myq6bi 570 193 various various JJ cord-018017-c8myq6bi 570 194 aspects aspect NNS cord-018017-c8myq6bi 570 195 of of IN cord-018017-c8myq6bi 570 196 Equine equine JJ cord-018017-c8myq6bi 570 197 arteritis arteritis NN cord-018017-c8myq6bi 570 198 virus virus NN cord-018017-c8myq6bi 570 199 amplification amplification NN cord-018017-c8myq6bi 570 200 in in IN cord-018017-c8myq6bi 570 201 cell cell NN cord-018017-c8myq6bi 570 202 culture culture NN cord-018017-c8myq6bi 570 203 PCR PCR NNP cord-018017-c8myq6bi 570 204 for for IN cord-018017-c8myq6bi 570 205 detection detection NN cord-018017-c8myq6bi 570 206 of of IN cord-018017-c8myq6bi 570 207 oseltamivir oseltamivir NNP cord-018017-c8myq6bi 570 208 resistance resistance NN cord-018017-c8myq6bi 570 209 mutation mutation NN cord-018017-c8myq6bi 570 210 in in IN cord-018017-c8myq6bi 570 211 influenza influenza NN cord-018017-c8myq6bi 570 212 A(H7N9 A(H7N9 NNP cord-018017-c8myq6bi 570 213 ) ) -RRB- cord-018017-c8myq6bi 571 1 virus virus NNP cord-018017-c8myq6bi 571 2 IgG IgG NNP cord-018017-c8myq6bi 571 3 antibodies antibody NNS cord-018017-c8myq6bi 571 4 to to IN cord-018017-c8myq6bi 571 5 dengue dengue NN cord-018017-c8myq6bi 571 6 enhanced enhance VBN cord-018017-c8myq6bi 571 7 for for IN cord-018017-c8myq6bi 571 8 FcγRIIIA fcγriiia NN cord-018017-c8myq6bi 571 9 binding binding NN cord-018017-c8myq6bi 571 10 determine determine NN cord-018017-c8myq6bi 571 11 disease disease NN cord-018017-c8myq6bi 571 12 severity severity NN cord-018017-c8myq6bi 571 13 Gene gene NN cord-018017-c8myq6bi 571 14 - - HYPH cord-018017-c8myq6bi 571 15 specific specific JJ cord-018017-c8myq6bi 571 16 countermeasures countermeasure NNS cord-018017-c8myq6bi 571 17 against against IN cord-018017-c8myq6bi 571 18 Ebola Ebola NNP cord-018017-c8myq6bi 571 19 virus virus NN cord-018017-c8myq6bi 571 20 based base VBN cord-018017-c8myq6bi 571 21 on on IN cord-018017-c8myq6bi 571 22 antisense antisense NN cord-018017-c8myq6bi 571 23 phosphorodiamidate phosphorodiamidate NNP cord-018017-c8myq6bi 571 24 morpholino morpholino NNP cord-018017-c8myq6bi 571 25 oligomers oligomer NNS cord-018017-c8myq6bi 571 26 Advanced advanced JJ cord-018017-c8myq6bi 571 27 antisense antisense NN cord-018017-c8myq6bi 571 28 therapies therapy NNS cord-018017-c8myq6bi 571 29 for for IN cord-018017-c8myq6bi 571 30 postexposure postexposure NN cord-018017-c8myq6bi 571 31 protection protection NN cord-018017-c8myq6bi 571 32 against against IN cord-018017-c8myq6bi 571 33 lethal lethal JJ cord-018017-c8myq6bi 571 34 filovirus filovirus NN cord-018017-c8myq6bi 571 35 infections infection NNS cord-018017-c8myq6bi 571 36 Single single JJ cord-018017-c8myq6bi 571 37 component component NN cord-018017-c8myq6bi 572 1 AVI-7537 AVI-7537 NNP cord-018017-c8myq6bi 572 2 antisense antisense NN cord-018017-c8myq6bi 572 3 compound compound NNP cord-018017-c8myq6bi 572 4 provides provide VBZ cord-018017-c8myq6bi 572 5 greater great JJR cord-018017-c8myq6bi 572 6 protection protection NN cord-018017-c8myq6bi 572 7 than than IN cord-018017-c8myq6bi 572 8 double double JJ cord-018017-c8myq6bi 572 9 component component NN cord-018017-c8myq6bi 572 10 AVI-6002 avi-6002 NN cord-018017-c8myq6bi 572 11 against against IN cord-018017-c8myq6bi 572 12 Lethal Lethal NNP cord-018017-c8myq6bi 572 13 Ebola Ebola NNP cord-018017-c8myq6bi 572 14 virus virus NN cord-018017-c8myq6bi 572 15 infection infection NN cord-018017-c8myq6bi 572 16 in in IN cord-018017-c8myq6bi 572 17 Rhesus Rhesus NNP cord-018017-c8myq6bi 572 18 Monkeys Monkeys NNP cord-018017-c8myq6bi 572 19 Isolation Isolation NNP cord-018017-c8myq6bi 572 20 of of IN cord-018017-c8myq6bi 572 21 an an DT cord-018017-c8myq6bi 572 22 arenavirus arenavirus NN cord-018017-c8myq6bi 572 23 closely closely RB cord-018017-c8myq6bi 572 24 related related JJ cord-018017-c8myq6bi 572 25 to to IN cord-018017-c8myq6bi 572 26 Lassa Lassa NNP cord-018017-c8myq6bi 572 27 virus virus NN cord-018017-c8myq6bi 572 28 from from IN cord-018017-c8myq6bi 572 29 Mastomys Mastomys NNP cord-018017-c8myq6bi 572 30 natalensis natalensis NN cord-018017-c8myq6bi 572 31 in in IN cord-018017-c8myq6bi 572 32 south south JJ cord-018017-c8myq6bi 572 33 - - HYPH cord-018017-c8myq6bi 572 34 east east NNP cord-018017-c8myq6bi 572 35 Inhibition Inhibition NNP cord-018017-c8myq6bi 572 36 of of IN cord-018017-c8myq6bi 572 37 coxsackievirus coxsackievirus NNP cord-018017-c8myq6bi 572 38 b3 b3 NN cord-018017-c8myq6bi 572 39 in in IN cord-018017-c8myq6bi 572 40 cell cell NN cord-018017-c8myq6bi 572 41 cultures culture NNS cord-018017-c8myq6bi 572 42 and and CC cord-018017-c8myq6bi 572 43 in in IN cord-018017-c8myq6bi 572 44 mice mouse NNS cord-018017-c8myq6bi 572 45 by by IN cord-018017-c8myq6bi 572 46 Peptide peptide NN cord-018017-c8myq6bi 572 47 - - HYPH cord-018017-c8myq6bi 572 48 conjugated conjugate VBN cord-018017-c8myq6bi 572 49 morpholino morpholino NNP cord-018017-c8myq6bi 572 50 oligomers oligomer NNS cord-018017-c8myq6bi 572 51 targeting target VBG cord-018017-c8myq6bi 572 52 the the DT cord-018017-c8myq6bi 572 53 internal internal JJ cord-018017-c8myq6bi 572 54 ribosomal ribosomal JJ cord-018017-c8myq6bi 572 55 entry entry NN cord-018017-c8myq6bi 572 56 site site NN cord-018017-c8myq6bi 572 57 Inhibition inhibition NN cord-018017-c8myq6bi 572 58 of of IN cord-018017-c8myq6bi 572 59 Rous rous JJ cord-018017-c8myq6bi 572 60 sarcoma sarcoma NN cord-018017-c8myq6bi 572 61 virus virus NN cord-018017-c8myq6bi 572 62 replication replication NN cord-018017-c8myq6bi 572 63 and and CC cord-018017-c8myq6bi 572 64 transformation transformation NN cord-018017-c8myq6bi 572 65 by by IN cord-018017-c8myq6bi 572 66 a a DT cord-018017-c8myq6bi 572 67 specific specific JJ cord-018017-c8myq6bi 572 68 oligodeoxynucleotide oligodeoxynucleotide NN cord-018017-c8myq6bi 572 69 Characteristic characteristic JJ cord-018017-c8myq6bi 572 70 chromosomal chromosomal JJ cord-018017-c8myq6bi 572 71 abnormalities abnormality NNS cord-018017-c8myq6bi 572 72 in in IN cord-018017-c8myq6bi 572 73 biopsies biopsy NNS cord-018017-c8myq6bi 572 74 and and CC cord-018017-c8myq6bi 572 75 lymphoid lymphoid JJ cord-018017-c8myq6bi 572 76 - - HYPH cord-018017-c8myq6bi 572 77 cell cell NN cord-018017-c8myq6bi 572 78 lines line NNS cord-018017-c8myq6bi 572 79 from from IN cord-018017-c8myq6bi 572 80 patients patient NNS cord-018017-c8myq6bi 572 81 with with IN cord-018017-c8myq6bi 572 82 Burkitt Burkitt NNP cord-018017-c8myq6bi 572 83 and and CC cord-018017-c8myq6bi 572 84 non non JJ cord-018017-c8myq6bi 572 85 - - JJ cord-018017-c8myq6bi 572 86 Burkitt burkitt JJ cord-018017-c8myq6bi 572 87 lymphomas lymphoma NNS cord-018017-c8myq6bi 572 88 Effect Effect NNP cord-018017-c8myq6bi 572 89 of of IN cord-018017-c8myq6bi 572 90 early early JJ cord-018017-c8myq6bi 572 91 and and CC cord-018017-c8myq6bi 572 92 late late JJ cord-018017-c8myq6bi 572 93 GB GB NNP cord-018017-c8myq6bi 572 94 virus virus NN cord-018017-c8myq6bi 572 95 C c NN cord-018017-c8myq6bi 572 96 viremia viremia NN cord-018017-c8myq6bi 572 97 on on IN cord-018017-c8myq6bi 572 98 survival survival NN cord-018017-c8myq6bi 572 99 of of IN cord-018017-c8myq6bi 572 100 HIV HIV NNP cord-018017-c8myq6bi 572 101 - - HYPH cord-018017-c8myq6bi 572 102 infected infect VBN cord-018017-c8myq6bi 572 103 individuals individual NNS cord-018017-c8myq6bi 572 104 : : : cord-018017-c8myq6bi 572 105 a a DT cord-018017-c8myq6bi 572 106 meta meta JJ cord-018017-c8myq6bi 572 107 - - HYPH cord-018017-c8myq6bi 572 108 analysis analysis NN cord-018017-c8myq6bi 572 109 Suppression suppression NN cord-018017-c8myq6bi 572 110 of of IN cord-018017-c8myq6bi 572 111 porcine porcine JJ cord-018017-c8myq6bi 572 112 reproductive reproductive JJ cord-018017-c8myq6bi 572 113 and and CC cord-018017-c8myq6bi 572 114 respiratory respiratory JJ cord-018017-c8myq6bi 572 115 syndrome syndrome NN cord-018017-c8myq6bi 572 116 virus virus NN cord-018017-c8myq6bi 572 117 replication replication NN cord-018017-c8myq6bi 572 118 by by IN cord-018017-c8myq6bi 572 119 morpholino morpholino NNP cord-018017-c8myq6bi 572 120 antisense antisense NNP cord-018017-c8myq6bi 572 121 oligomers oligomer NNS cord-018017-c8myq6bi 573 1 West West NNP cord-018017-c8myq6bi 573 2 Nile Nile NNP cord-018017-c8myq6bi 573 3 virus virus NN cord-018017-c8myq6bi 573 4 genome genome NN cord-018017-c8myq6bi 573 5 cyclization cyclization NN cord-018017-c8myq6bi 573 6 and and CC cord-018017-c8myq6bi 573 7 RNA RNA NNP cord-018017-c8myq6bi 573 8 replication replication NN cord-018017-c8myq6bi 573 9 require require VBP cord-018017-c8myq6bi 573 10 two two CD cord-018017-c8myq6bi 573 11 pairs pair NNS cord-018017-c8myq6bi 573 12 of of IN cord-018017-c8myq6bi 573 13 long long JJ cord-018017-c8myq6bi 573 14 - - HYPH cord-018017-c8myq6bi 573 15 distance distance NN cord-018017-c8myq6bi 573 16 RNA RNA NNP cord-018017-c8myq6bi 573 17 interactions interaction NNS