id	sid	tid	token	lemma	pos
cord-017420-tjwxec77	1	1	key	key	JJ
cord-017420-tjwxec77	2	1	:	:	:
cord-017420-tjwxec77	2	2	cord-017420-tjwxec77	cord-017420-tjwxec77	NN
cord-017420-tjwxec77	2	3	authors	author	NNS
cord-017420-tjwxec77	2	4	:	:	:
cord-017420-tjwxec77	2	5	Stephens	Stephens	NNP
cord-017420-tjwxec77	2	6	,	,	,
cord-017420-tjwxec77	2	7	R.	R.	NNP
cord-017420-tjwxec77	2	8	Scott	Scott	NNP
cord-017420-tjwxec77	2	9	title	title	NN
cord-017420-tjwxec77	2	10	:	:	:
cord-017420-tjwxec77	2	11	Neutropenic	Neutropenic	NNP
cord-017420-tjwxec77	2	12	Fever	Fever	NNP
cord-017420-tjwxec77	2	13	in	in	IN
cord-017420-tjwxec77	2	14	the	the	DT
cord-017420-tjwxec77	2	15	Intensive	Intensive	NNP
cord-017420-tjwxec77	2	16	Care	Care	NNP
cord-017420-tjwxec77	2	17	Unit	Unit	NNP
cord-017420-tjwxec77	2	18	date	date	NN
cord-017420-tjwxec77	2	19	:	:	:
cord-017420-tjwxec77	2	20	2019	2019	CD
cord-017420-tjwxec77	2	21	-	-	HYPH
cord-017420-tjwxec77	2	22	07	07	CD
cord-017420-tjwxec77	2	23	-	-	HYPH
cord-017420-tjwxec77	2	24	09	09	CD
cord-017420-tjwxec77	2	25	journal	journal	NN
cord-017420-tjwxec77	2	26	:	:	:
cord-017420-tjwxec77	3	1	Oncologic	Oncologic	NNP
cord-017420-tjwxec77	3	2	Critical	Critical	NNP
cord-017420-tjwxec77	3	3	Care	Care	NNP
cord-017420-tjwxec77	3	4	DOI	doi	NN
cord-017420-tjwxec77	3	5	:	:	:
cord-017420-tjwxec77	3	6	10.1007/978	10.1007/978	CD
cord-017420-tjwxec77	3	7	-	-	HYPH
cord-017420-tjwxec77	3	8	3	3	CD
cord-017420-tjwxec77	3	9	-	-	HYPH
cord-017420-tjwxec77	3	10	319	319	CD
cord-017420-tjwxec77	3	11	-	-	HYPH
cord-017420-tjwxec77	3	12	74588	74588	CD
cord-017420-tjwxec77	3	13	-	-	HYPH
cord-017420-tjwxec77	3	14	6_118	6_118	NNP
cord-017420-tjwxec77	3	15	sha	sha	NN
cord-017420-tjwxec77	3	16	:	:	:
cord-017420-tjwxec77	3	17	a156b0bc7fabb877f09b0f0ad24e37947479f288	a156b0bc7fabb877f09b0f0ad24e37947479f288	NNP
cord-017420-tjwxec77	3	18	doc_id	doc_id	CD
cord-017420-tjwxec77	3	19	:	:	:
cord-017420-tjwxec77	3	20	17420	17420	CD
cord-017420-tjwxec77	3	21	cord_uid	cord_uid	NNS
cord-017420-tjwxec77	3	22	:	:	:
cord-017420-tjwxec77	3	23	tjwxec77	tjwxec77	.
cord-017420-tjwxec77	4	1	Neutropenic	neutropenic	JJ
cord-017420-tjwxec77	4	2	fever	fever	NN
cord-017420-tjwxec77	4	3	is	be	VBZ
cord-017420-tjwxec77	4	4	a	a	DT
cord-017420-tjwxec77	4	5	common	common	JJ
cord-017420-tjwxec77	4	6	and	and	CC
cord-017420-tjwxec77	4	7	potentially	potentially	RB
cord-017420-tjwxec77	4	8	life	life	NN
cord-017420-tjwxec77	4	9	-	-	HYPH
cord-017420-tjwxec77	4	10	threatening	threaten	VBG
cord-017420-tjwxec77	4	11	condition	condition	NN
cord-017420-tjwxec77	4	12	in	in	IN
cord-017420-tjwxec77	4	13	patients	patient	NNS
cord-017420-tjwxec77	4	14	treated	treat	VBN
cord-017420-tjwxec77	4	15	for	for	IN
cord-017420-tjwxec77	4	16	cancer	cancer	NN
cord-017420-tjwxec77	4	17	.	.	.
cord-017420-tjwxec77	5	1	Rapid	rapid	JJ
cord-017420-tjwxec77	5	2	initiation	initiation	NN
cord-017420-tjwxec77	5	3	of	of	IN
cord-017420-tjwxec77	5	4	appropriate	appropriate	JJ
cord-017420-tjwxec77	5	5	antimicrobial	antimicrobial	JJ
cord-017420-tjwxec77	5	6	therapy	therapy	NN
cord-017420-tjwxec77	5	7	is	be	VBZ
cord-017420-tjwxec77	5	8	necessary	necessary	JJ
cord-017420-tjwxec77	5	9	to	to	TO
cord-017420-tjwxec77	5	10	decrease	decrease	VB
cord-017420-tjwxec77	5	11	the	the	DT
cord-017420-tjwxec77	5	12	risk	risk	NN
cord-017420-tjwxec77	5	13	of	of	IN
cord-017420-tjwxec77	5	14	mortality	mortality	NN
cord-017420-tjwxec77	5	15	.	.	.
cord-017420-tjwxec77	6	1	Most	Most	JJS
cord-017420-tjwxec77	6	2	infections	infection	NNS
cord-017420-tjwxec77	6	3	are	be	VBP
cord-017420-tjwxec77	6	4	due	due	JJ
cord-017420-tjwxec77	6	5	to	to	IN
cord-017420-tjwxec77	6	6	gram	gram	NN
cord-017420-tjwxec77	6	7	-	-	HYPH
cord-017420-tjwxec77	6	8	positive	positive	JJ
cord-017420-tjwxec77	6	9	organisms	organism	NNS
cord-017420-tjwxec77	6	10	,	,	,
cord-017420-tjwxec77	6	11	but	but	CC
cord-017420-tjwxec77	6	12	the	the	DT
cord-017420-tjwxec77	6	13	mortality	mortality	NN
cord-017420-tjwxec77	6	14	rate	rate	NN
cord-017420-tjwxec77	6	15	is	be	VBZ
cord-017420-tjwxec77	6	16	higher	high	JJR
cord-017420-tjwxec77	6	17	for	for	IN
cord-017420-tjwxec77	6	18	gram	gram	NN
cord-017420-tjwxec77	6	19	-	-	HYPH
cord-017420-tjwxec77	6	20	negative	negative	JJ
cord-017420-tjwxec77	6	21	infections	infection	NNS
cord-017420-tjwxec77	6	22	.	.	.
cord-017420-tjwxec77	7	1	Multidrug	multidrug	JJ
cord-017420-tjwxec77	7	2	-	-	HYPH
cord-017420-tjwxec77	7	3	resistant	resistant	JJ
cord-017420-tjwxec77	7	4	organisms	organism	NNS
cord-017420-tjwxec77	7	5	are	be	VBP
cord-017420-tjwxec77	7	6	an	an	DT
cord-017420-tjwxec77	7	7	emerging	emerge	VBG
cord-017420-tjwxec77	7	8	threat	threat	NN
cord-017420-tjwxec77	7	9	to	to	IN
cord-017420-tjwxec77	7	10	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	7	11	patients	patient	NNS
cord-017420-tjwxec77	7	12	.	.	.
cord-017420-tjwxec77	8	1	Increasing	increase	VBG
cord-017420-tjwxec77	8	2	data	datum	NNS
cord-017420-tjwxec77	8	3	suggest	suggest	VBP
cord-017420-tjwxec77	8	4	that	that	IN
cord-017420-tjwxec77	8	5	the	the	DT
cord-017420-tjwxec77	8	6	pathophysiology	pathophysiology	NN
cord-017420-tjwxec77	8	7	of	of	IN
cord-017420-tjwxec77	8	8	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	8	9	fever	fever	NN
cord-017420-tjwxec77	8	10	and	and	CC
cord-017420-tjwxec77	8	11	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	8	12	sepsis	sepsis	NN
cord-017420-tjwxec77	8	13	is	be	VBZ
cord-017420-tjwxec77	8	14	substantially	substantially	RB
cord-017420-tjwxec77	8	15	different	different	JJ
cord-017420-tjwxec77	8	16	from	from	IN
cord-017420-tjwxec77	8	17	non	non	JJ
cord-017420-tjwxec77	8	18	-	-	JJ
cord-017420-tjwxec77	8	19	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	8	20	fever	fever	NN
cord-017420-tjwxec77	8	21	and	and	CC
cord-017420-tjwxec77	8	22	sepsis	sepsis	NN
cord-017420-tjwxec77	8	23	.	.	.
cord-017420-tjwxec77	9	1	Additional	additional	JJ
cord-017420-tjwxec77	9	2	research	research	NN
cord-017420-tjwxec77	9	3	is	be	VBZ
cord-017420-tjwxec77	9	4	needed	need	VBN
cord-017420-tjwxec77	9	5	to	to	IN
cord-017420-tjwxec77	9	6	both	both	DT
cord-017420-tjwxec77	9	7	further	further	RB
cord-017420-tjwxec77	9	8	elucidate	elucidate	VB
cord-017420-tjwxec77	9	9	the	the	DT
cord-017420-tjwxec77	9	10	pathogenesis	pathogenesis	NN
cord-017420-tjwxec77	9	11	of	of	IN
cord-017420-tjwxec77	9	12	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	9	13	fever	fever	NN
cord-017420-tjwxec77	9	14	and	and	CC
cord-017420-tjwxec77	9	15	to	to	TO
cord-017420-tjwxec77	9	16	develop	develop	VB
cord-017420-tjwxec77	9	17	additional	additional	JJ
cord-017420-tjwxec77	9	18	effective	effective	JJ
cord-017420-tjwxec77	9	19	antimicrobials	antimicrobial	NNS
cord-017420-tjwxec77	9	20	.	.	.
cord-017420-tjwxec77	10	1	Neutropenic	neutropenic	JJ
cord-017420-tjwxec77	10	2	fever	fever	NN
cord-017420-tjwxec77	10	3	is	be	VBZ
cord-017420-tjwxec77	10	4	one	one	CD
cord-017420-tjwxec77	10	5	of	of	IN
cord-017420-tjwxec77	10	6	the	the	DT
cord-017420-tjwxec77	10	7	defining	define	VBG
cord-017420-tjwxec77	10	8	conditions	condition	NNS
cord-017420-tjwxec77	10	9	of	of	IN
cord-017420-tjwxec77	10	10	oncologic	oncologic	JJ
cord-017420-tjwxec77	10	11	critical	critical	JJ
cord-017420-tjwxec77	10	12	care	care	NN
cord-017420-tjwxec77	10	13	.	.	.
cord-017420-tjwxec77	11	1	Neutropenic	neutropenic	JJ
cord-017420-tjwxec77	11	2	fever	fever	NN
cord-017420-tjwxec77	11	3	is	be	VBZ
cord-017420-tjwxec77	11	4	defined	define	VBN
cord-017420-tjwxec77	11	5	as	as	IN
cord-017420-tjwxec77	11	6	a	a	DT
cord-017420-tjwxec77	11	7	single	single	JJ
cord-017420-tjwxec77	11	8	temperature	temperature	NN
cord-017420-tjwxec77	11	9	higher	high	JJR
cord-017420-tjwxec77	11	10	than	than	IN
cord-017420-tjwxec77	11	11	38.3	38.3	CD
cord-017420-tjwxec77	11	12	C	c	NN
cord-017420-tjwxec77	11	13	or	or	CC
cord-017420-tjwxec77	11	14	a	a	DT
cord-017420-tjwxec77	11	15	sustained	sustained	JJ
cord-017420-tjwxec77	11	16	temperature	temperature	NN
cord-017420-tjwxec77	11	17	greater	great	JJR
cord-017420-tjwxec77	11	18	than	than	IN
cord-017420-tjwxec77	11	19	38.0	38.0	CD
cord-017420-tjwxec77	11	20	C	c	NN
cord-017420-tjwxec77	11	21	for	for	IN
cord-017420-tjwxec77	11	22	more	more	JJR
cord-017420-tjwxec77	11	23	than	than	IN
cord-017420-tjwxec77	11	24	1	1	CD
cord-017420-tjwxec77	11	25	h	h	NN
cord-017420-tjwxec77	11	26	,	,	,
cord-017420-tjwxec77	11	27	in	in	IN
cord-017420-tjwxec77	11	28	the	the	DT
cord-017420-tjwxec77	11	29	presence	presence	NN
cord-017420-tjwxec77	11	30	of	of	IN
cord-017420-tjwxec77	11	31	an	an	DT
cord-017420-tjwxec77	11	32	absolute	absolute	JJ
cord-017420-tjwxec77	11	33	neutrophil	neutrophil	NN
cord-017420-tjwxec77	11	34	count	count	NN
cord-017420-tjwxec77	11	35	[	[	-LRB-
cord-017420-tjwxec77	11	36	ANC	ANC	NNP
cord-017420-tjwxec77	11	37	]	]	-RRB-
cord-017420-tjwxec77	11	38	)	)	-RRB-
cord-017420-tjwxec77	11	39	less	less	JJR
cord-017420-tjwxec77	11	40	than	than	IN
cord-017420-tjwxec77	11	41	1500	1500	CD
cord-017420-tjwxec77	11	42	cells	cell	NNS
cord-017420-tjwxec77	11	43	/	/	SYM
cord-017420-tjwxec77	11	44	mm	mm	NNP
cord-017420-tjwxec77	11	45	3	3	CD
cord-017420-tjwxec77	11	46	,	,	,
cord-017420-tjwxec77	11	47	though	though	IN
cord-017420-tjwxec77	11	48	many	many	JJ
cord-017420-tjwxec77	11	49	centers	center	NNS
cord-017420-tjwxec77	11	50	and	and	CC
cord-017420-tjwxec77	11	51	guidelines	guideline	NNS
cord-017420-tjwxec77	11	52	use	use	VBP
cord-017420-tjwxec77	11	53	an	an	DT
cord-017420-tjwxec77	11	54	ANC	ANC	NNP
cord-017420-tjwxec77	11	55	cutoff	cutoff	NN
cord-017420-tjwxec77	11	56	of	of	IN
cord-017420-tjwxec77	11	57	less	less	JJR
cord-017420-tjwxec77	11	58	than	than	IN
cord-017420-tjwxec77	11	59	500	500	CD
cord-017420-tjwxec77	11	60	cells	cell	NNS
cord-017420-tjwxec77	11	61	/	/	SYM
cord-017420-tjwxec77	11	62	mm	mm	NN
cord-017420-tjwxec77	11	63	3	3	CD
cord-017420-tjwxec77	11	64	[	[	-LRB-
cord-017420-tjwxec77	11	65	28	28	CD
cord-017420-tjwxec77	11	66	,	,	,
cord-017420-tjwxec77	11	67	33	33	CD
cord-017420-tjwxec77	11	68	]	]	-RRB-
cord-017420-tjwxec77	11	69	.	.	.
cord-017420-tjwxec77	12	1	Exceedingly	exceedingly	RB
cord-017420-tjwxec77	12	2	common	common	JJ
cord-017420-tjwxec77	12	3	in	in	IN
cord-017420-tjwxec77	12	4	patients	patient	NNS
cord-017420-tjwxec77	12	5	receiving	receive	VBG
cord-017420-tjwxec77	12	6	cytotoxic	cytotoxic	JJ
cord-017420-tjwxec77	12	7	chemotherapy	chemotherapy	NN
cord-017420-tjwxec77	12	8	,	,	,
cord-017420-tjwxec77	12	9	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	12	10	fever	fever	NN
cord-017420-tjwxec77	12	11	is	be	VBZ
cord-017420-tjwxec77	12	12	a	a	DT
cord-017420-tjwxec77	12	13	medical	medical	JJ
cord-017420-tjwxec77	12	14	emergency	emergency	NN
cord-017420-tjwxec77	12	15	which	which	WDT
cord-017420-tjwxec77	12	16	requires	require	VBZ
cord-017420-tjwxec77	12	17	urgent	urgent	JJ
cord-017420-tjwxec77	12	18	initiation	initiation	NN
cord-017420-tjwxec77	12	19	of	of	IN
cord-017420-tjwxec77	12	20	broad	broad	JJ
cord-017420-tjwxec77	12	21	-	-	HYPH
cord-017420-tjwxec77	12	22	spectrum	spectrum	NN
cord-017420-tjwxec77	12	23	antibiotics	antibiotic	NNS
cord-017420-tjwxec77	12	24	.	.	.
cord-017420-tjwxec77	13	1	Any	any	DT
cord-017420-tjwxec77	13	2	oncologic	oncologic	JJ
cord-017420-tjwxec77	13	3	patient	patient	NN
cord-017420-tjwxec77	13	4	receiving	receive	VBG
cord-017420-tjwxec77	13	5	myelosuppressive	myelosuppressive	NNP
cord-017420-tjwxec77	13	6	chemotherapy	chemotherapy	NN
cord-017420-tjwxec77	13	7	is	be	VBZ
cord-017420-tjwxec77	13	8	at	at	IN
cord-017420-tjwxec77	13	9	risk	risk	NN
cord-017420-tjwxec77	13	10	of	of	IN
cord-017420-tjwxec77	13	11	developing	develop	VBG
cord-017420-tjwxec77	13	12	neutropenia	neutropenia	NN
cord-017420-tjwxec77	13	13	and	and	CC
cord-017420-tjwxec77	13	14	opportunistic	opportunistic	JJ
cord-017420-tjwxec77	13	15	infections	infection	NNS
cord-017420-tjwxec77	13	16	,	,	,
cord-017420-tjwxec77	13	17	but	but	CC
cord-017420-tjwxec77	13	18	profound	profound	JJ
cord-017420-tjwxec77	13	19	neutropenia	neutropenia	NN
cord-017420-tjwxec77	13	20	with	with	IN
cord-017420-tjwxec77	13	21	life	life	NN
cord-017420-tjwxec77	13	22	-	-	HYPH
cord-017420-tjwxec77	13	23	threatening	threaten	VBG
cord-017420-tjwxec77	13	24	infectious	infectious	JJ
cord-017420-tjwxec77	13	25	complications	complication	NNS
cord-017420-tjwxec77	13	26	is	be	VBZ
cord-017420-tjwxec77	13	27	most	most	RBS
cord-017420-tjwxec77	13	28	commonly	commonly	RB
cord-017420-tjwxec77	13	29	seen	see	VBN
cord-017420-tjwxec77	13	30	in	in	IN
cord-017420-tjwxec77	13	31	patients	patient	NNS
cord-017420-tjwxec77	13	32	with	with	IN
cord-017420-tjwxec77	13	33	hematologic	hematologic	JJ
cord-017420-tjwxec77	13	34	malignancies	malignancy	NNS
cord-017420-tjwxec77	13	35	.	.	.
cord-017420-tjwxec77	14	1	This	this	DT
cord-017420-tjwxec77	14	2	can	can	MD
cord-017420-tjwxec77	14	3	occur	occur	VB
cord-017420-tjwxec77	14	4	during	during	IN
cord-017420-tjwxec77	14	5	aplasia	aplasia	NNP
cord-017420-tjwxec77	14	6	and	and	CC
cord-017420-tjwxec77	14	7	before	before	IN
cord-017420-tjwxec77	14	8	engraftment	engraftment	NN
cord-017420-tjwxec77	14	9	in	in	IN
cord-017420-tjwxec77	14	10	patients	patient	NNS
cord-017420-tjwxec77	14	11	receiving	receive	VBG
cord-017420-tjwxec77	14	12	hematopoietic	hematopoietic	JJ
cord-017420-tjwxec77	14	13	stem	stem	NN
cord-017420-tjwxec77	14	14	cell	cell	NN
cord-017420-tjwxec77	14	15	transplant	transplant	NN
cord-017420-tjwxec77	14	16	(	(	-LRB-
cord-017420-tjwxec77	14	17	HSCT	HSCT	NNP
cord-017420-tjwxec77	14	18	)	)	-RRB-
cord-017420-tjwxec77	14	19	or	or	CC
cord-017420-tjwxec77	14	20	from	from	IN
cord-017420-tjwxec77	14	21	disease	disease	NN
cord-017420-tjwxec77	14	22	-	-	HYPH
cord-017420-tjwxec77	14	23	related	relate	VBN
cord-017420-tjwxec77	14	24	or	or	CC
cord-017420-tjwxec77	14	25	treatment	treatment	NN
cord-017420-tjwxec77	14	26	-	-	HYPH
cord-017420-tjwxec77	14	27	induced	induce	VBN
cord-017420-tjwxec77	14	28	cytopenias	cytopenia	NNS
cord-017420-tjwxec77	14	29	in	in	IN
cord-017420-tjwxec77	14	30	other	other	JJ
cord-017420-tjwxec77	14	31	hematologic	hematologic	JJ
cord-017420-tjwxec77	14	32	malignancy	malignancy	NN
cord-017420-tjwxec77	14	33	patients	patient	NNS
cord-017420-tjwxec77	14	34	.	.	.
cord-017420-tjwxec77	15	1	While	while	IN
cord-017420-tjwxec77	15	2	there	there	EX
cord-017420-tjwxec77	15	3	are	be	VBP
cord-017420-tjwxec77	15	4	many	many	JJ
cord-017420-tjwxec77	15	5	potential	potential	JJ
cord-017420-tjwxec77	15	6	causes	cause	NNS
cord-017420-tjwxec77	15	7	of	of	IN
cord-017420-tjwxec77	15	8	fevers	fever	NNS
cord-017420-tjwxec77	15	9	in	in	IN
cord-017420-tjwxec77	15	10	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	15	11	hosts	host	NNS
cord-017420-tjwxec77	15	12	,	,	,
cord-017420-tjwxec77	15	13	both	both	CC
cord-017420-tjwxec77	15	14	infectious	infectious	JJ
cord-017420-tjwxec77	15	15	and	and	CC
cord-017420-tjwxec77	15	16	noninfectious	noninfectious	JJ
cord-017420-tjwxec77	15	17	,	,	,
cord-017420-tjwxec77	15	18	fevers	fever	NNS
cord-017420-tjwxec77	15	19	must	must	MD
cord-017420-tjwxec77	15	20	be	be	VB
cord-017420-tjwxec77	15	21	presumed	presume	VBN
cord-017420-tjwxec77	15	22	to	to	TO
cord-017420-tjwxec77	15	23	be	be	VB
cord-017420-tjwxec77	15	24	infectious	infectious	JJ
cord-017420-tjwxec77	15	25	in	in	IN
cord-017420-tjwxec77	15	26	origin	origin	NN
cord-017420-tjwxec77	15	27	.	.	.
cord-017420-tjwxec77	16	1	Potential	potential	JJ
cord-017420-tjwxec77	16	2	infectious	infectious	JJ
cord-017420-tjwxec77	16	3	agents	agent	NNS
cord-017420-tjwxec77	16	4	and	and	CC
cord-017420-tjwxec77	16	5	sources	source	NNS
cord-017420-tjwxec77	16	6	of	of	IN
cord-017420-tjwxec77	16	7	infection	infection	NN
cord-017420-tjwxec77	16	8	are	be	VBP
cord-017420-tjwxec77	16	9	legion	legion	NN
cord-017420-tjwxec77	16	10	and	and	CC
cord-017420-tjwxec77	16	11	include	include	VBP
cord-017420-tjwxec77	16	12	viruses	virus	NNS
cord-017420-tjwxec77	16	13	,	,	,
cord-017420-tjwxec77	16	14	bacteria	bacteria	NNS
cord-017420-tjwxec77	16	15	,	,	,
cord-017420-tjwxec77	16	16	and	and	CC
cord-017420-tjwxec77	16	17	fungus	fungus	NN
cord-017420-tjwxec77	16	18	.	.	.
cord-017420-tjwxec77	17	1	Viral	viral	JJ
cord-017420-tjwxec77	17	2	pathogens	pathogen	NNS
cord-017420-tjwxec77	17	3	include	include	VBP
cord-017420-tjwxec77	17	4	respiratory	respiratory	JJ
cord-017420-tjwxec77	17	5	viruses	virus	NNS
cord-017420-tjwxec77	17	6	(	(	-LRB-
cord-017420-tjwxec77	17	7	e.g.	e.g.	RB
cord-017420-tjwxec77	17	8	,	,	,
cord-017420-tjwxec77	17	9	respiratory	respiratory	JJ
cord-017420-tjwxec77	17	10	syncytial	syncytial	JJ
cord-017420-tjwxec77	17	11	virus	virus	NN
cord-017420-tjwxec77	17	12	,	,	,
cord-017420-tjwxec77	17	13	rhinovirus	rhinovirus	NN
cord-017420-tjwxec77	17	14	,	,	,
cord-017420-tjwxec77	17	15	adenovirus	adenovirus	NN
cord-017420-tjwxec77	17	16	,	,	,
cord-017420-tjwxec77	17	17	coronavirus	coronavirus	NN
cord-017420-tjwxec77	17	18	,	,	,
cord-017420-tjwxec77	17	19	influenza	influenza	NN
cord-017420-tjwxec77	17	20	,	,	,
cord-017420-tjwxec77	17	21	parainfluenza	parainfluenza	NNP
cord-017420-tjwxec77	17	22	)	)	-RRB-
cord-017420-tjwxec77	17	23	,	,	,
cord-017420-tjwxec77	17	24	reactivated	reactivate	VBN
cord-017420-tjwxec77	17	25	or	or	CC
cord-017420-tjwxec77	17	26	de	de	FW
cord-017420-tjwxec77	17	27	novo	novo	NNP
cord-017420-tjwxec77	17	28	herpes	herpes	NN
cord-017420-tjwxec77	17	29	viruses	virus	NNS
cord-017420-tjwxec77	17	30	(	(	-LRB-
cord-017420-tjwxec77	17	31	e.g.	e.g.	RB
cord-017420-tjwxec77	17	32	,	,	,
cord-017420-tjwxec77	17	33	herpes	herpes	NN
cord-017420-tjwxec77	17	34	simplex	simplex	NN
cord-017420-tjwxec77	17	35	,	,	,
cord-017420-tjwxec77	17	36	cytomegalovirus	cytomegalovirus	NNP
cord-017420-tjwxec77	17	37	,	,	,
cord-017420-tjwxec77	17	38	Epstein	Epstein	NNP
cord-017420-tjwxec77	17	39	-	-	HYPH
cord-017420-tjwxec77	17	40	Barr	Barr	NNP
cord-017420-tjwxec77	17	41	virus	virus	NN
cord-017420-tjwxec77	17	42	)	)	-RRB-
cord-017420-tjwxec77	17	43	,	,	,
cord-017420-tjwxec77	17	44	and	and	CC
cord-017420-tjwxec77	17	45	many	many	JJ
cord-017420-tjwxec77	17	46	other	other	JJ
cord-017420-tjwxec77	17	47	potential	potential	JJ
cord-017420-tjwxec77	17	48	candidates	candidate	NNS
cord-017420-tjwxec77	17	49	.	.	.
cord-017420-tjwxec77	18	1	Bacterial	bacterial	JJ
cord-017420-tjwxec77	18	2	infections	infection	NNS
cord-017420-tjwxec77	18	3	may	may	MD
cord-017420-tjwxec77	18	4	arise	arise	VB
cord-017420-tjwxec77	18	5	from	from	IN
cord-017420-tjwxec77	18	6	gut	gut	NN
cord-017420-tjwxec77	18	7	translocation	translocation	NN
cord-017420-tjwxec77	18	8	,	,	,
cord-017420-tjwxec77	18	9	oral	oral	JJ
cord-017420-tjwxec77	18	10	mucosal	mucosal	JJ
cord-017420-tjwxec77	18	11	translocation	translocation	NN
cord-017420-tjwxec77	18	12	,	,	,
cord-017420-tjwxec77	18	13	infection	infection	NN
cord-017420-tjwxec77	18	14	of	of	IN
cord-017420-tjwxec77	18	15	indwelling	indwell	VBG
cord-017420-tjwxec77	18	16	vascular	vascular	JJ
cord-017420-tjwxec77	18	17	catheters	catheter	NNS
cord-017420-tjwxec77	18	18	,	,	,
cord-017420-tjwxec77	18	19	skin	skin	NN
cord-017420-tjwxec77	18	20	and	and	CC
cord-017420-tjwxec77	18	21	soft	soft	JJ
cord-017420-tjwxec77	18	22	tissue	tissue	NN
cord-017420-tjwxec77	18	23	infections	infection	NNS
cord-017420-tjwxec77	18	24	,	,	,
cord-017420-tjwxec77	18	25	pneumonias	pneumonia	NNS
cord-017420-tjwxec77	18	26	,	,	,
cord-017420-tjwxec77	18	27	and	and	CC
cord-017420-tjwxec77	18	28	urinary	urinary	JJ
cord-017420-tjwxec77	18	29	sources	source	NNS
cord-017420-tjwxec77	18	30	.	.	.
cord-017420-tjwxec77	19	1	Fungal	fungal	JJ
cord-017420-tjwxec77	19	2	infections	infection	NNS
cord-017420-tjwxec77	19	3	typically	typically	RB
cord-017420-tjwxec77	19	4	arise	arise	VBP
cord-017420-tjwxec77	19	5	from	from	IN
cord-017420-tjwxec77	19	6	gut	gut	NN
cord-017420-tjwxec77	19	7	translocation	translocation	NN
cord-017420-tjwxec77	19	8	,	,	,
cord-017420-tjwxec77	19	9	fungal	fungal	JJ
cord-017420-tjwxec77	19	10	pneumonias	pneumonia	NNS
cord-017420-tjwxec77	19	11	(	(	-LRB-
cord-017420-tjwxec77	19	12	e.g.	e.g.	RB
cord-017420-tjwxec77	19	13	,	,	,
cord-017420-tjwxec77	19	14	aspergillosis	aspergillosis	NNP
cord-017420-tjwxec77	19	15	)	)	-RRB-
cord-017420-tjwxec77	19	16	,	,	,
cord-017420-tjwxec77	19	17	and	and	CC
cord-017420-tjwxec77	19	18	vascular	vascular	JJ
cord-017420-tjwxec77	19	19	catheters	catheter	NNS
cord-017420-tjwxec77	19	20	.	.	.
cord-017420-tjwxec77	20	1	Drug	drug	NN
cord-017420-tjwxec77	20	2	fevers	fever	NNS
cord-017420-tjwxec77	20	3	or	or	CC
cord-017420-tjwxec77	20	4	"	"	``
cord-017420-tjwxec77	20	5	tumor	tumor	NN
cord-017420-tjwxec77	20	6	fevers	fever	NNS
cord-017420-tjwxec77	20	7	"	"	''
cord-017420-tjwxec77	20	8	are	be	VBP
cord-017420-tjwxec77	20	9	the	the	DT
cord-017420-tjwxec77	20	10	most	most	RBS
cord-017420-tjwxec77	20	11	common	common	JJ
cord-017420-tjwxec77	20	12	example	example	NN
cord-017420-tjwxec77	20	13	of	of	IN
cord-017420-tjwxec77	20	14	noninfectious	noninfectious	JJ
cord-017420-tjwxec77	20	15	fevers	fever	NNS
cord-017420-tjwxec77	20	16	,	,	,
cord-017420-tjwxec77	20	17	but	but	CC
cord-017420-tjwxec77	20	18	these	these	DT
cord-017420-tjwxec77	20	19	are	be	VBP
cord-017420-tjwxec77	20	20	diagnoses	diagnosis	NNS
cord-017420-tjwxec77	20	21	of	of	IN
cord-017420-tjwxec77	20	22	exclusion	exclusion	NN
cord-017420-tjwxec77	20	23	.	.	.
cord-017420-tjwxec77	21	1	Neutropenic	neutropenic	JJ
cord-017420-tjwxec77	21	2	fever	fever	NN
cord-017420-tjwxec77	21	3	occurs	occur	VBZ
cord-017420-tjwxec77	21	4	in	in	IN
cord-017420-tjwxec77	21	5	up	up	IN
cord-017420-tjwxec77	21	6	to	to	TO
cord-017420-tjwxec77	21	7	50	50	CD
cord-017420-tjwxec77	21	8	%	%	NN
cord-017420-tjwxec77	21	9	of	of	IN
cord-017420-tjwxec77	21	10	patients	patient	NNS
cord-017420-tjwxec77	21	11	with	with	IN
cord-017420-tjwxec77	21	12	solid	solid	JJ
cord-017420-tjwxec77	21	13	tumors	tumor	NNS
cord-017420-tjwxec77	21	14	receiving	receive	VBG
cord-017420-tjwxec77	21	15	cytotoxic	cytotoxic	JJ
cord-017420-tjwxec77	21	16	chemotherapy	chemotherapy	NN
cord-017420-tjwxec77	21	17	and	and	CC
cord-017420-tjwxec77	21	18	in	in	IN
cord-017420-tjwxec77	21	19	more	more	JJR
cord-017420-tjwxec77	21	20	than	than	IN
cord-017420-tjwxec77	21	21	80	80	CD
cord-017420-tjwxec77	21	22	%	%	NN
cord-017420-tjwxec77	21	23	of	of	IN
cord-017420-tjwxec77	21	24	patients	patient	NNS
cord-017420-tjwxec77	21	25	receiving	receive	VBG
cord-017420-tjwxec77	21	26	chemotherapy	chemotherapy	NN
cord-017420-tjwxec77	21	27	for	for	IN
cord-017420-tjwxec77	21	28	hematologic	hematologic	JJ
cord-017420-tjwxec77	21	29	malignancies	malignancy	NNS
cord-017420-tjwxec77	21	30	or	or	CC
cord-017420-tjwxec77	21	31	undergoing	undergo	VBG
cord-017420-tjwxec77	21	32	HSCT	HSCT	NNP
cord-017420-tjwxec77	21	33	[	[	-LRB-
cord-017420-tjwxec77	21	34	28	28	CD
cord-017420-tjwxec77	21	35	]	]	-RRB-
cord-017420-tjwxec77	21	36	.	.	.
cord-017420-tjwxec77	22	1	In	in	IN
cord-017420-tjwxec77	22	2	2012	2012	CD
cord-017420-tjwxec77	22	3	,	,	,
cord-017420-tjwxec77	22	4	more	more	JJR
cord-017420-tjwxec77	22	5	than	than	IN
cord-017420-tjwxec77	22	6	90,000	90,000	CD
cord-017420-tjwxec77	22	7	adults	adult	NNS
cord-017420-tjwxec77	22	8	were	be	VBD
cord-017420-tjwxec77	22	9	hospitalized	hospitalize	VBN
cord-017420-tjwxec77	22	10	for	for	IN
cord-017420-tjwxec77	22	11	cancer	cancer	NN
cord-017420-tjwxec77	22	12	-	-	HYPH
cord-017420-tjwxec77	22	13	related	relate	VBN
cord-017420-tjwxec77	22	14	neutropenia	neutropenia	NN
cord-017420-tjwxec77	22	15	,	,	,
cord-017420-tjwxec77	22	16	with	with	IN
cord-017420-tjwxec77	22	17	a	a	DT
cord-017420-tjwxec77	22	18	total	total	JJ
cord-017420-tjwxec77	22	19	cost	cost	NN
cord-017420-tjwxec77	22	20	of	of	IN
cord-017420-tjwxec77	22	21	$	$	$
cord-017420-tjwxec77	22	22	2.3	2.3	CD
cord-017420-tjwxec77	22	23	billion	billion	CD
cord-017420-tjwxec77	22	24	[	[	-LRB-
cord-017420-tjwxec77	22	25	75	75	CD
cord-017420-tjwxec77	22	26	]	]	-RRB-
cord-017420-tjwxec77	22	27	.	.	.
cord-017420-tjwxec77	23	1	In	in	IN
cord-017420-tjwxec77	23	2	-	-	HYPH
cord-017420-tjwxec77	23	3	hospital	hospital	NN
cord-017420-tjwxec77	23	4	mortality	mortality	NN
cord-017420-tjwxec77	23	5	for	for	IN
cord-017420-tjwxec77	23	6	all	all	DT
cord-017420-tjwxec77	23	7	patients	patient	NNS
cord-017420-tjwxec77	23	8	admitted	admit	VBN
cord-017420-tjwxec77	23	9	with	with	IN
cord-017420-tjwxec77	23	10	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	23	11	fever	fever	NN
cord-017420-tjwxec77	23	12	is	be	VBZ
cord-017420-tjwxec77	23	13	nearly	nearly	RB
cord-017420-tjwxec77	23	14	10	10	CD
cord-017420-tjwxec77	23	15	%	%	NN
cord-017420-tjwxec77	23	16	;	;	,
cord-017420-tjwxec77	23	17	this	this	DT
cord-017420-tjwxec77	23	18	increases	increase	VBZ
cord-017420-tjwxec77	23	19	to	to	IN
cord-017420-tjwxec77	23	20	a	a	DT
cord-017420-tjwxec77	23	21	hospital	hospital	NN
cord-017420-tjwxec77	23	22	mortality	mortality	NN
cord-017420-tjwxec77	23	23	rate	rate	NN
cord-017420-tjwxec77	23	24	of	of	IN
cord-017420-tjwxec77	23	25	more	more	JJR
cord-017420-tjwxec77	23	26	than	than	IN
cord-017420-tjwxec77	23	27	15	15	CD
cord-017420-tjwxec77	23	28	%	%	NN
cord-017420-tjwxec77	23	29	for	for	IN
cord-017420-tjwxec77	23	30	patients	patient	NNS
cord-017420-tjwxec77	23	31	with	with	IN
cord-017420-tjwxec77	23	32	leukemia	leukemia	NN
cord-017420-tjwxec77	23	33	admitted	admit	VBN
cord-017420-tjwxec77	23	34	for	for	IN
cord-017420-tjwxec77	23	35	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	23	36	fever	fever	NN
cord-017420-tjwxec77	23	37	[	[	-LRB-
cord-017420-tjwxec77	23	38	37	37	CD
cord-017420-tjwxec77	23	39	]	]	-RRB-
cord-017420-tjwxec77	23	40	.	.	.
cord-017420-tjwxec77	24	1	Bacteremia	Bacteremia	NNP
cord-017420-tjwxec77	24	2	is	be	VBZ
cord-017420-tjwxec77	24	3	documented	document	VBN
cord-017420-tjwxec77	24	4	in	in	IN
cord-017420-tjwxec77	24	5	up	up	IN
cord-017420-tjwxec77	24	6	to	to	TO
cord-017420-tjwxec77	24	7	25	25	CD
cord-017420-tjwxec77	24	8	%	%	NN
cord-017420-tjwxec77	24	9	of	of	IN
cord-017420-tjwxec77	24	10	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	24	11	fever	fever	NN
cord-017420-tjwxec77	24	12	patients	patient	NNS
cord-017420-tjwxec77	24	13	[	[	-LRB-
cord-017420-tjwxec77	24	14	28	28	CD
cord-017420-tjwxec77	24	15	]	]	-RRB-
cord-017420-tjwxec77	24	16	.	.	.
cord-017420-tjwxec77	25	1	Whereas	whereas	IN
cord-017420-tjwxec77	25	2	in	in	IN
cord-017420-tjwxec77	25	3	the	the	DT
cord-017420-tjwxec77	25	4	past	past	JJ
cord-017420-tjwxec77	25	5	gram	gram	JJ
cord-017420-tjwxec77	25	6	-	-	HYPH
cord-017420-tjwxec77	25	7	negative	negative	JJ
cord-017420-tjwxec77	25	8	organisms	organism	NNS
cord-017420-tjwxec77	25	9	were	be	VBD
cord-017420-tjwxec77	25	10	commonly	commonly	RB
cord-017420-tjwxec77	25	11	cultured	culture	VBN
cord-017420-tjwxec77	25	12	,	,	,
cord-017420-tjwxec77	25	13	gram	gram	NN
cord-017420-tjwxec77	25	14	-	-	HYPH
cord-017420-tjwxec77	25	15	positive	positive	JJ
cord-017420-tjwxec77	25	16	organisms	organism	NNS
cord-017420-tjwxec77	25	17	,	,	,
cord-017420-tjwxec77	25	18	including	include	VBG
cord-017420-tjwxec77	25	19	staphylococci	staphylococcus	NNS
cord-017420-tjwxec77	25	20	,	,	,
cord-017420-tjwxec77	25	21	enterococci	enterococci	NNP
cord-017420-tjwxec77	25	22	,	,	,
cord-017420-tjwxec77	25	23	and	and	CC
cord-017420-tjwxec77	25	24	streptococci	streptococcus	NNS
cord-017420-tjwxec77	25	25	,	,	,
cord-017420-tjwxec77	25	26	are	be	VBP
cord-017420-tjwxec77	25	27	currently	currently	RB
cord-017420-tjwxec77	25	28	the	the	DT
cord-017420-tjwxec77	25	29	most	most	RBS
cord-017420-tjwxec77	25	30	commonly	commonly	RB
cord-017420-tjwxec77	25	31	isolated	isolate	VBN
cord-017420-tjwxec77	25	32	bacteria	bacteria	NNS
cord-017420-tjwxec77	25	33	[	[	-LRB-
cord-017420-tjwxec77	25	34	28	28	CD
cord-017420-tjwxec77	25	35	,	,	,
cord-017420-tjwxec77	25	36	50	50	CD
cord-017420-tjwxec77	25	37	]	]	-RRB-
cord-017420-tjwxec77	26	1	(	(	-LRB-
cord-017420-tjwxec77	26	2	Table	table	NN
cord-017420-tjwxec77	26	3	1	1	CD
cord-017420-tjwxec77	26	4	)	)	-RRB-
cord-017420-tjwxec77	26	5	.	.	.
cord-017420-tjwxec77	27	1	This	this	DT
cord-017420-tjwxec77	27	2	shift	shift	NN
cord-017420-tjwxec77	27	3	is	be	VBZ
cord-017420-tjwxec77	27	4	presumably	presumably	RB
cord-017420-tjwxec77	27	5	due	due	IN
cord-017420-tjwxec77	27	6	to	to	IN
cord-017420-tjwxec77	27	7	the	the	DT
cord-017420-tjwxec77	27	8	increased	increase	VBN
cord-017420-tjwxec77	27	9	use	use	NN
cord-017420-tjwxec77	27	10	of	of	IN
cord-017420-tjwxec77	27	11	long	long	JJ
cord-017420-tjwxec77	27	12	-	-	HYPH
cord-017420-tjwxec77	27	13	term	term	NN
cord-017420-tjwxec77	27	14	indwelling	indwell	VBG
cord-017420-tjwxec77	27	15	vascular	vascular	JJ
cord-017420-tjwxec77	27	16	catheters	catheter	NNS
cord-017420-tjwxec77	27	17	and	and	CC
cord-017420-tjwxec77	27	18	may	may	MD
cord-017420-tjwxec77	27	19	also	also	RB
cord-017420-tjwxec77	27	20	be	be	VB
cord-017420-tjwxec77	27	21	affected	affect	VBN
cord-017420-tjwxec77	27	22	by	by	IN
cord-017420-tjwxec77	27	23	increased	increase	VBN
cord-017420-tjwxec77	27	24	use	use	NN
cord-017420-tjwxec77	27	25	of	of	IN
cord-017420-tjwxec77	27	26	prophylaxis	prophylaxis	NN
cord-017420-tjwxec77	27	27	against	against	IN
cord-017420-tjwxec77	27	28	gram-	gram-	NNP
cord-017420-tjwxec77	27	29	[	[	-LRB-
cord-017420-tjwxec77	27	30	50	50	CD
cord-017420-tjwxec77	27	31	,	,	,
cord-017420-tjwxec77	27	32	59	59	CD
cord-017420-tjwxec77	27	33	]	]	-RRB-
cord-017420-tjwxec77	27	34	.	.	.
cord-017420-tjwxec77	28	1	Though	though	IN
cord-017420-tjwxec77	28	2	grampositive	grampositive	JJ
cord-017420-tjwxec77	28	3	infections	infection	NNS
cord-017420-tjwxec77	28	4	are	be	VBP
cord-017420-tjwxec77	28	5	more	more	RBR
cord-017420-tjwxec77	28	6	common	common	JJ
cord-017420-tjwxec77	28	7	,	,	,
cord-017420-tjwxec77	28	8	gramnegative	gramnegative	JJ
cord-017420-tjwxec77	28	9	infections	infection	NNS
cord-017420-tjwxec77	28	10	confer	confer	VBP
cord-017420-tjwxec77	28	11	a	a	DT
cord-017420-tjwxec77	28	12	higher	high	JJR
cord-017420-tjwxec77	28	13	risk	risk	NN
cord-017420-tjwxec77	28	14	of	of	IN
cord-017420-tjwxec77	28	15	mortality	mortality	NN
cord-017420-tjwxec77	28	16	[	[	-LRB-
cord-017420-tjwxec77	28	17	77	77	CD
cord-017420-tjwxec77	28	18	]	]	-RRB-
cord-017420-tjwxec77	28	19	.	.	.
cord-017420-tjwxec77	29	1	Fungal	fungal	JJ
cord-017420-tjwxec77	29	2	infections	infection	NNS
cord-017420-tjwxec77	29	3	,	,	,
cord-017420-tjwxec77	29	4	particularly	particularly	RB
cord-017420-tjwxec77	29	5	Candida	Candida	NNP
cord-017420-tjwxec77	29	6	and	and	CC
cord-017420-tjwxec77	29	7	Aspergillus	Aspergillus	NNP
cord-017420-tjwxec77	29	8	,	,	,
cord-017420-tjwxec77	29	9	are	be	VBP
cord-017420-tjwxec77	29	10	also	also	RB
cord-017420-tjwxec77	29	11	frequent	frequent	JJ
cord-017420-tjwxec77	29	12	,	,	,
cord-017420-tjwxec77	29	13	especially	especially	RB
cord-017420-tjwxec77	29	14	in	in	IN
cord-017420-tjwxec77	29	15	patients	patient	NNS
cord-017420-tjwxec77	29	16	with	with	IN
cord-017420-tjwxec77	29	17	prolonged	prolonged	JJ
cord-017420-tjwxec77	29	18	or	or	CC
cord-017420-tjwxec77	29	19	profound	profound	JJ
cord-017420-tjwxec77	29	20	neutropenia	neutropenia	NN
cord-017420-tjwxec77	29	21	[	[	-LRB-
cord-017420-tjwxec77	29	22	33	33	CD
cord-017420-tjwxec77	29	23	]	]	-RRB-
cord-017420-tjwxec77	29	24	.	.	.
cord-017420-tjwxec77	30	1	Respiratory	respiratory	JJ
cord-017420-tjwxec77	30	2	viruses	virus	NNS
cord-017420-tjwxec77	30	3	can	can	MD
cord-017420-tjwxec77	30	4	be	be	VB
cord-017420-tjwxec77	30	5	isolated	isolate	VBN
cord-017420-tjwxec77	30	6	in	in	IN
cord-017420-tjwxec77	30	7	approximately	approximately	RB
cord-017420-tjwxec77	30	8	20	20	CD
cord-017420-tjwxec77	30	9	%	%	NN
cord-017420-tjwxec77	30	10	of	of	IN
cord-017420-tjwxec77	30	11	patients	patient	NNS
cord-017420-tjwxec77	30	12	[	[	-LRB-
cord-017420-tjwxec77	30	13	34	34	CD
cord-017420-tjwxec77	30	14	]	]	-RRB-
cord-017420-tjwxec77	30	15	.	.	.
cord-017420-tjwxec77	31	1	Despite	despite	IN
cord-017420-tjwxec77	31	2	best	good	JJS
cord-017420-tjwxec77	31	3	efforts	effort	NNS
cord-017420-tjwxec77	31	4	,	,	,
cord-017420-tjwxec77	31	5	no	no	DT
cord-017420-tjwxec77	31	6	causative	causative	JJ
cord-017420-tjwxec77	31	7	organism	organism	NN
cord-017420-tjwxec77	31	8	can	can	MD
cord-017420-tjwxec77	31	9	be	be	VB
cord-017420-tjwxec77	31	10	identified	identify	VBN
cord-017420-tjwxec77	31	11	in	in	IN
cord-017420-tjwxec77	31	12	about	about	RB
cord-017420-tjwxec77	31	13	50	50	CD
cord-017420-tjwxec77	31	14	%	%	NN
cord-017420-tjwxec77	31	15	of	of	IN
cord-017420-tjwxec77	31	16	cases	case	NNS
cord-017420-tjwxec77	31	17	of	of	IN
cord-017420-tjwxec77	31	18	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	31	19	fever	fever	NN
cord-017420-tjwxec77	31	20	[	[	-LRB-
cord-017420-tjwxec77	31	21	28	28	CD
cord-017420-tjwxec77	31	22	,	,	,
cord-017420-tjwxec77	31	23	33	33	CD
cord-017420-tjwxec77	31	24	]	]	-RRB-
cord-017420-tjwxec77	31	25	.	.	.
cord-017420-tjwxec77	32	1	Sepsis	sepsis	NN
cord-017420-tjwxec77	32	2	has	have	VBZ
cord-017420-tjwxec77	32	3	been	be	VBN
cord-017420-tjwxec77	32	4	most	most	RBS
cord-017420-tjwxec77	32	5	recently	recently	RB
cord-017420-tjwxec77	32	6	defined	define	VBN
cord-017420-tjwxec77	32	7	as	as	IN
cord-017420-tjwxec77	32	8	"	"	``
cord-017420-tjwxec77	32	9	lifethreatening	lifethreatening	JJ
cord-017420-tjwxec77	32	10	organ	organ	NN
cord-017420-tjwxec77	32	11	dysfunction	dysfunction	NN
cord-017420-tjwxec77	32	12	caused	cause	VBN
cord-017420-tjwxec77	32	13	by	by	IN
cord-017420-tjwxec77	32	14	a	a	DT
cord-017420-tjwxec77	32	15	dysregulated	dysregulate	VBN
cord-017420-tjwxec77	32	16	host	host	NN
cord-017420-tjwxec77	32	17	response	response	NN
cord-017420-tjwxec77	32	18	to	to	IN
cord-017420-tjwxec77	32	19	infection	infection	NN
cord-017420-tjwxec77	32	20	"	"	''
cord-017420-tjwxec77	32	21	[	[	-LRB-
cord-017420-tjwxec77	32	22	70	70	CD
cord-017420-tjwxec77	32	23	]	]	-RRB-
cord-017420-tjwxec77	32	24	.	.	.
cord-017420-tjwxec77	33	1	A	a	DT
cord-017420-tjwxec77	33	2	premium	premium	NN
cord-017420-tjwxec77	33	3	is	be	VBZ
cord-017420-tjwxec77	33	4	placed	place	VBN
cord-017420-tjwxec77	33	5	on	on	IN
cord-017420-tjwxec77	33	6	identification	identification	NN
cord-017420-tjwxec77	33	7	of	of	IN
cord-017420-tjwxec77	33	8	organ	organ	NN
cord-017420-tjwxec77	33	9	dysfunction	dysfunction	NN
cord-017420-tjwxec77	33	10	using	use	VBG
cord-017420-tjwxec77	33	11	either	either	CC
cord-017420-tjwxec77	33	12	the	the	DT
cord-017420-tjwxec77	33	13	Sequential	Sequential	NNP
cord-017420-tjwxec77	33	14	Organ	Organ	NNP
cord-017420-tjwxec77	33	15	Failure	Failure	NNP
cord-017420-tjwxec77	33	16	Assessment	Assessment	NNP
cord-017420-tjwxec77	33	17	(	(	-LRB-
cord-017420-tjwxec77	33	18	SOFA	SOFA	NNP
cord-017420-tjwxec77	33	19	)	)	-RRB-
cord-017420-tjwxec77	33	20	score	score	NN
cord-017420-tjwxec77	33	21	or	or	CC
cord-017420-tjwxec77	33	22	the	the	DT
cord-017420-tjwxec77	33	23	Quick	quick	JJ
cord-017420-tjwxec77	33	24	SOFA	sofa	NN
cord-017420-tjwxec77	33	25	(	(	-LRB-
cord-017420-tjwxec77	33	26	qSOFA	qsofa	NN
cord-017420-tjwxec77	33	27	)	)	-RRB-
cord-017420-tjwxec77	33	28	score	score	NN
cord-017420-tjwxec77	33	29	;	;	:
cord-017420-tjwxec77	33	30	the	the	DT
cord-017420-tjwxec77	33	31	presence	presence	NN
cord-017420-tjwxec77	33	32	of	of	IN
cord-017420-tjwxec77	33	33	organ	organ	NN
cord-017420-tjwxec77	33	34	dysfunction	dysfunction	NN
cord-017420-tjwxec77	33	35	in	in	IN
cord-017420-tjwxec77	33	36	the	the	DT
cord-017420-tjwxec77	33	37	setting	setting	NN
cord-017420-tjwxec77	33	38	of	of	IN
cord-017420-tjwxec77	33	39	a	a	DT
cord-017420-tjwxec77	33	40	suspected	suspect	VBN
cord-017420-tjwxec77	33	41	or	or	CC
cord-017420-tjwxec77	33	42	proven	prove	VBN
cord-017420-tjwxec77	33	43	infection	infection	NN
cord-017420-tjwxec77	33	44	is	be	VBZ
cord-017420-tjwxec77	33	45	sufficient	sufficient	JJ
cord-017420-tjwxec77	33	46	to	to	TO
cord-017420-tjwxec77	33	47	diagnose	diagnose	VB
cord-017420-tjwxec77	33	48	sepsis	sepsis	NN
cord-017420-tjwxec77	33	49	(	(	-LRB-
cord-017420-tjwxec77	33	50	Tables	table	NNS
cord-017420-tjwxec77	33	51	2	2	CD
cord-017420-tjwxec77	33	52	and	and	CC
cord-017420-tjwxec77	33	53	3	3	CD
cord-017420-tjwxec77	33	54	)	)	-RRB-
cord-017420-tjwxec77	33	55	.	.	.
cord-017420-tjwxec77	34	1	Septic	septic	JJ
cord-017420-tjwxec77	34	2	shock	shock	NN
cord-017420-tjwxec77	34	3	is	be	VBZ
cord-017420-tjwxec77	34	4	defined	define	VBN
cord-017420-tjwxec77	34	5	by	by	IN
cord-017420-tjwxec77	34	6	the	the	DT
cord-017420-tjwxec77	34	7	need	need	NN
cord-017420-tjwxec77	34	8	for	for	IN
cord-017420-tjwxec77	34	9	vasopressors	vasopressor	NNS
cord-017420-tjwxec77	34	10	to	to	TO
cord-017420-tjwxec77	34	11	maintain	maintain	VB
cord-017420-tjwxec77	34	12	a	a	DT
cord-017420-tjwxec77	34	13	mean	mean	JJ
cord-017420-tjwxec77	34	14	arterial	arterial	JJ
cord-017420-tjwxec77	34	15	pressure	pressure	NN
cord-017420-tjwxec77	34	16	(	(	-LRB-
cord-017420-tjwxec77	34	17	MAP	MAP	NNP
cord-017420-tjwxec77	34	18	)	)	-RRB-
cord-017420-tjwxec77	34	19	!	!	.
cord-017420-tjwxec77	35	1	65	65	CD
cord-017420-tjwxec77	35	2	mmHg	mmHg	NNS
cord-017420-tjwxec77	35	3	or	or	CC
cord-017420-tjwxec77	35	4	a	a	DT
cord-017420-tjwxec77	35	5	serum	serum	NN
cord-017420-tjwxec77	35	6	lactate	lactate	NN
cord-017420-tjwxec77	35	7	>	>	XX
cord-017420-tjwxec77	35	8	2	2	CD
cord-017420-tjwxec77	35	9	mmol	mmol	NNP
cord-017420-tjwxec77	35	10	/	/	SYM
cord-017420-tjwxec77	35	11	L	l	NN
cord-017420-tjwxec77	35	12	despite	despite	IN
cord-017420-tjwxec77	35	13	adequate	adequate	JJ
cord-017420-tjwxec77	35	14	volume	volume	NN
cord-017420-tjwxec77	35	15	resuscitation	resuscitation	NN
cord-017420-tjwxec77	35	16	.	.	.
cord-017420-tjwxec77	36	1	There	there	EX
cord-017420-tjwxec77	36	2	is	be	VBZ
cord-017420-tjwxec77	36	3	no	no	DT
cord-017420-tjwxec77	36	4	specific	specific	JJ
cord-017420-tjwxec77	36	5	consensus	consensus	NN
cord-017420-tjwxec77	36	6	definition	definition	NN
cord-017420-tjwxec77	36	7	for	for	IN
cord-017420-tjwxec77	36	8	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	36	9	sepsis	sepsis	NN
cord-017420-tjwxec77	36	10	,	,	,
cord-017420-tjwxec77	36	11	other	other	JJ
cord-017420-tjwxec77	36	12	than	than	IN
cord-017420-tjwxec77	36	13	sepsis	sepsis	NN
cord-017420-tjwxec77	36	14	occurring	occur	VBG
cord-017420-tjwxec77	36	15	in	in	IN
cord-017420-tjwxec77	36	16	the	the	DT
cord-017420-tjwxec77	36	17	presence	presence	NN
cord-017420-tjwxec77	36	18	of	of	IN
cord-017420-tjwxec77	36	19	neutropenia	neutropenia	NN
cord-017420-tjwxec77	36	20	.	.	.
cord-017420-tjwxec77	37	1	Any	any	DT
cord-017420-tjwxec77	37	2	evidence	evidence	NN
cord-017420-tjwxec77	37	3	of	of	IN
cord-017420-tjwxec77	37	4	organ	organ	NN
cord-017420-tjwxec77	37	5	dysfunction	dysfunction	NN
cord-017420-tjwxec77	37	6	,	,	,
cord-017420-tjwxec77	37	7	including	include	VBG
cord-017420-tjwxec77	37	8	an	an	DT
cord-017420-tjwxec77	37	9	elevated	elevated	JJ
cord-017420-tjwxec77	37	10	lactate	lactate	NN
cord-017420-tjwxec77	37	11	,	,	,
cord-017420-tjwxec77	37	12	in	in	IN
cord-017420-tjwxec77	37	13	the	the	DT
cord-017420-tjwxec77	37	14	presence	presence	NN
cord-017420-tjwxec77	37	15	of	of	IN
cord-017420-tjwxec77	37	16	neutropenia	neutropenia	NN
cord-017420-tjwxec77	37	17	should	should	MD
cord-017420-tjwxec77	37	18	be	be	VB
cord-017420-tjwxec77	37	19	treated	treat	VBN
cord-017420-tjwxec77	37	20	as	as	IN
cord-017420-tjwxec77	37	21	a	a	DT
cord-017420-tjwxec77	37	22	potential	potential	JJ
cord-017420-tjwxec77	37	23	indicator	indicator	NN
cord-017420-tjwxec77	37	24	of	of	IN
cord-017420-tjwxec77	37	25	sepsis	sepsis	NN
cord-017420-tjwxec77	37	26	.	.	.
cord-017420-tjwxec77	38	1	There	there	EX
cord-017420-tjwxec77	38	2	are	be	VBP
cord-017420-tjwxec77	38	3	few	few	JJ
cord-017420-tjwxec77	38	4	reliable	reliable	JJ
cord-017420-tjwxec77	38	5	data	datum	NNS
cord-017420-tjwxec77	38	6	on	on	IN
cord-017420-tjwxec77	38	7	the	the	DT
cord-017420-tjwxec77	38	8	incidence	incidence	NN
cord-017420-tjwxec77	38	9	of	of	IN
cord-017420-tjwxec77	38	10	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	38	11	sepsis	sepsis	NN
cord-017420-tjwxec77	38	12	or	or	CC
cord-017420-tjwxec77	38	13	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	38	14	septic	septic	JJ
cord-017420-tjwxec77	38	15	shock	shock	NN
cord-017420-tjwxec77	38	16	.	.	.
cord-017420-tjwxec77	39	1	It	-PRON-	PRP
cord-017420-tjwxec77	39	2	has	have	VBZ
cord-017420-tjwxec77	39	3	been	be	VBN
cord-017420-tjwxec77	39	4	estimated	estimate	VBN
cord-017420-tjwxec77	39	5	that	that	IN
cord-017420-tjwxec77	39	6	50	50	CD
cord-017420-tjwxec77	39	7	%	%	NN
cord-017420-tjwxec77	39	8	of	of	IN
cord-017420-tjwxec77	39	9	patients	patient	NNS
cord-017420-tjwxec77	39	10	with	with	IN
cord-017420-tjwxec77	39	11	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	39	12	fever	fever	NN
cord-017420-tjwxec77	39	13	will	will	MD
cord-017420-tjwxec77	39	14	develop	develop	VB
cord-017420-tjwxec77	39	15	sepsis	sepsis	NN
cord-017420-tjwxec77	39	16	,	,	,
cord-017420-tjwxec77	39	17	and	and	CC
cord-017420-tjwxec77	39	18	up	up	IN
cord-017420-tjwxec77	39	19	to	to	TO
cord-017420-tjwxec77	39	20	10	10	CD
cord-017420-tjwxec77	39	21	%	%	NN
cord-017420-tjwxec77	39	22	of	of	IN
cord-017420-tjwxec77	39	23	patients	patient	NNS
cord-017420-tjwxec77	39	24	with	with	IN
cord-017420-tjwxec77	39	25	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	39	26	fever	fever	NN
cord-017420-tjwxec77	39	27	will	will	MD
cord-017420-tjwxec77	39	28	progress	progress	VB
cord-017420-tjwxec77	39	29	to	to	IN
cord-017420-tjwxec77	39	30	septic	septic	JJ
cord-017420-tjwxec77	39	31	shock	shock	NN
cord-017420-tjwxec77	39	32	[	[	-LRB-
cord-017420-tjwxec77	39	33	33	33	CD
cord-017420-tjwxec77	39	34	]	]	-RRB-
cord-017420-tjwxec77	39	35	.	.	.
cord-017420-tjwxec77	40	1	Among	among	IN
cord-017420-tjwxec77	40	2	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	40	3	allogeneic	allogeneic	IN
cord-017420-tjwxec77	40	4	HSCT	HSCT	NNP
cord-017420-tjwxec77	40	5	patients	patient	NNS
cord-017420-tjwxec77	40	6	,	,	,
cord-017420-tjwxec77	40	7	approximately	approximately	RB
cord-017420-tjwxec77	40	8	10	10	CD
cord-017420-tjwxec77	40	9	%	%	NN
cord-017420-tjwxec77	40	10	will	will	MD
cord-017420-tjwxec77	40	11	develop	develop	VB
cord-017420-tjwxec77	40	12	severe	severe	JJ
cord-017420-tjwxec77	40	13	sepsis	sepsis	NN
cord-017420-tjwxec77	40	14	during	during	IN
cord-017420-tjwxec77	40	15	the	the	DT
cord-017420-tjwxec77	40	16	engraftment	engraftment	NN
cord-017420-tjwxec77	40	17	period	period	NN
cord-017420-tjwxec77	40	18	[	[	-LRB-
cord-017420-tjwxec77	40	19	38	38	CD
cord-017420-tjwxec77	40	20	]	]	-RRB-
cord-017420-tjwxec77	40	21	.	.	.
cord-017420-tjwxec77	41	1	Cytotoxic	cytotoxic	JJ
cord-017420-tjwxec77	41	2	chemotherapy	chemotherapy	NN
cord-017420-tjwxec77	41	3	or	or	CC
cord-017420-tjwxec77	41	4	cytotoxic	cytotoxic	JJ
cord-017420-tjwxec77	41	5	radiation	radiation	NN
cord-017420-tjwxec77	41	6	,	,	,
cord-017420-tjwxec77	41	7	whether	whether	IN
cord-017420-tjwxec77	41	8	given	give	VBN
cord-017420-tjwxec77	41	9	as	as	IN
cord-017420-tjwxec77	41	10	an	an	DT
cord-017420-tjwxec77	41	11	antitumor	antitumor	JJ
cord-017420-tjwxec77	41	12	agent	agent	NN
cord-017420-tjwxec77	41	13	or	or	CC
cord-017420-tjwxec77	41	14	conditioning	conditioning	NN
cord-017420-tjwxec77	41	15	regimen	regimen	NN
cord-017420-tjwxec77	41	16	for	for	IN
cord-017420-tjwxec77	41	17	HSCT	HSCT	NNP
cord-017420-tjwxec77	41	18	,	,	,
cord-017420-tjwxec77	41	19	induces	induce	VBZ
cord-017420-tjwxec77	41	20	neutropenia	neutropenia	NN
cord-017420-tjwxec77	41	21	by	by	IN
cord-017420-tjwxec77	41	22	injuring	injure	VBG
cord-017420-tjwxec77	41	23	or	or	CC
cord-017420-tjwxec77	41	24	destroying	destroy	VBG
cord-017420-tjwxec77	41	25	hematopoietic	hematopoietic	JJ
cord-017420-tjwxec77	41	26	precursor	precursor	NN
cord-017420-tjwxec77	41	27	cells	cell	NNS
cord-017420-tjwxec77	41	28	within	within	IN
cord-017420-tjwxec77	41	29	the	the	DT
cord-017420-tjwxec77	41	30	bone	bone	NN
cord-017420-tjwxec77	41	31	marrow	marrow	NN
cord-017420-tjwxec77	41	32	as	as	RB
cord-017420-tjwxec77	41	33	well	well	RB
cord-017420-tjwxec77	41	34	as	as	IN
cord-017420-tjwxec77	41	35	injuring	injure	VBG
cord-017420-tjwxec77	41	36	the	the	DT
cord-017420-tjwxec77	41	37	bone	bone	NN
cord-017420-tjwxec77	41	38	marrow	marrow	NN
cord-017420-tjwxec77	41	39	structure	structure	NN
cord-017420-tjwxec77	41	40	itself	-PRON-	PRP
cord-017420-tjwxec77	41	41	[	[	-LRB-
cord-017420-tjwxec77	41	42	44	44	CD
cord-017420-tjwxec77	41	43	]	]	-RRB-
cord-017420-tjwxec77	41	44	.	.	.
cord-017420-tjwxec77	42	1	Circulating	circulate	VBG
cord-017420-tjwxec77	42	2	[	[	-LRB-
cord-017420-tjwxec77	42	3	43	43	CD
cord-017420-tjwxec77	42	4	]	]	-RRB-
cord-017420-tjwxec77	42	5	,	,	,
cord-017420-tjwxec77	42	6	so	so	RB
cord-017420-tjwxec77	42	7	neutropenia	neutropenia	NN
cord-017420-tjwxec77	42	8	develops	develop	VBZ
cord-017420-tjwxec77	42	9	rapidly	rapidly	RB
cord-017420-tjwxec77	42	10	after	after	IN
cord-017420-tjwxec77	42	11	myelosuppressive	myelosuppressive	NNP
cord-017420-tjwxec77	42	12	therapy	therapy	NN
cord-017420-tjwxec77	42	13	.	.	.
cord-017420-tjwxec77	43	1	Depending	depend	VBG
cord-017420-tjwxec77	43	2	on	on	IN
cord-017420-tjwxec77	43	3	the	the	DT
cord-017420-tjwxec77	43	4	chemotherapy	chemotherapy	NN
cord-017420-tjwxec77	43	5	employed	employ	VBN
cord-017420-tjwxec77	43	6	,	,	,
cord-017420-tjwxec77	43	7	circulating	circulate	VBG
cord-017420-tjwxec77	43	8	neutrophils	neutrophil	NNS
cord-017420-tjwxec77	43	9	and	and	CC
cord-017420-tjwxec77	43	10	other	other	JJ
cord-017420-tjwxec77	43	11	white	white	JJ
cord-017420-tjwxec77	43	12	blood	blood	NN
cord-017420-tjwxec77	43	13	cells	cell	NNS
cord-017420-tjwxec77	43	14	may	may	MD
cord-017420-tjwxec77	43	15	also	also	RB
cord-017420-tjwxec77	43	16	be	be	VB
cord-017420-tjwxec77	43	17	damaged	damage	VBN
cord-017420-tjwxec77	43	18	or	or	CC
cord-017420-tjwxec77	43	19	destroyed	destroy	VBN
cord-017420-tjwxec77	43	20	,	,	,
cord-017420-tjwxec77	43	21	causing	cause	VBG
cord-017420-tjwxec77	43	22	a	a	DT
cord-017420-tjwxec77	43	23	more	more	RBR
cord-017420-tjwxec77	43	24	rapid	rapid	JJ
cord-017420-tjwxec77	43	25	leukopenia	leukopenia	NN
cord-017420-tjwxec77	43	26	than	than	IN
cord-017420-tjwxec77	43	27	regimens	regimen	NNS
cord-017420-tjwxec77	43	28	which	which	WDT
cord-017420-tjwxec77	43	29	only	only	RB
cord-017420-tjwxec77	43	30	affect	affect	VBP
cord-017420-tjwxec77	43	31	the	the	DT
cord-017420-tjwxec77	43	32	marrow	marrow	NN
cord-017420-tjwxec77	43	33	.	.	.
cord-017420-tjwxec77	44	1	Some	some	DT
cord-017420-tjwxec77	44	2	agents	agent	NNS
cord-017420-tjwxec77	44	3	will	will	MD
cord-017420-tjwxec77	44	4	injure	injure	VB
cord-017420-tjwxec77	44	5	progenitor	progenitor	NN
cord-017420-tjwxec77	44	6	cells	cell	NNS
cord-017420-tjwxec77	44	7	but	but	CC
cord-017420-tjwxec77	44	8	not	not	RB
cord-017420-tjwxec77	44	9	primitive	primitive	JJ
cord-017420-tjwxec77	44	10	stem	stem	NN
cord-017420-tjwxec77	44	11	cells	cell	NNS
cord-017420-tjwxec77	44	12	(	(	-LRB-
cord-017420-tjwxec77	44	13	which	which	WDT
cord-017420-tjwxec77	44	14	re	re	NNS
cord-017420-tjwxec77	44	15	-	-	VBP
cord-017420-tjwxec77	44	16	populate	populate	VB
cord-017420-tjwxec77	44	17	the	the	DT
cord-017420-tjwxec77	44	18	progenitor	progenitor	NN
cord-017420-tjwxec77	44	19	cells	cell	NNS
cord-017420-tjwxec77	44	20	)	)	-RRB-
cord-017420-tjwxec77	44	21	,	,	,
cord-017420-tjwxec77	44	22	whereas	whereas	IN
cord-017420-tjwxec77	44	23	other	other	JJ
cord-017420-tjwxec77	44	24	agents	agent	NNS
cord-017420-tjwxec77	44	25	will	will	MD
cord-017420-tjwxec77	44	26	injure	injure	VB
cord-017420-tjwxec77	44	27	all	all	DT
cord-017420-tjwxec77	44	28	cells	cell	NNS
cord-017420-tjwxec77	44	29	in	in	IN
cord-017420-tjwxec77	44	30	the	the	DT
cord-017420-tjwxec77	44	31	marrow	marrow	NN
cord-017420-tjwxec77	44	32	[	[	-LRB-
cord-017420-tjwxec77	44	33	44	44	CD
cord-017420-tjwxec77	44	34	]	]	-RRB-
cord-017420-tjwxec77	44	35	.	.	.
cord-017420-tjwxec77	45	1	In	in	IN
cord-017420-tjwxec77	45	2	the	the	DT
cord-017420-tjwxec77	45	3	normal	normal	JJ
cord-017420-tjwxec77	45	4	patient	patient	NN
cord-017420-tjwxec77	45	5	with	with	IN
cord-017420-tjwxec77	45	6	a	a	DT
cord-017420-tjwxec77	45	7	localized	localize	VBN
cord-017420-tjwxec77	45	8	infection	infection	NN
cord-017420-tjwxec77	45	9	,	,	,
cord-017420-tjwxec77	45	10	neutrophils	neutrophil	NNS
cord-017420-tjwxec77	45	11	are	be	VBP
cord-017420-tjwxec77	45	12	rapidly	rapidly	RB
cord-017420-tjwxec77	45	13	recruited	recruit	VBN
cord-017420-tjwxec77	45	14	at	at	IN
cord-017420-tjwxec77	45	15	the	the	DT
cord-017420-tjwxec77	45	16	onset	onset	NN
cord-017420-tjwxec77	45	17	of	of	IN
cord-017420-tjwxec77	45	18	focal	focal	JJ
cord-017420-tjwxec77	45	19	infection	infection	NN
cord-017420-tjwxec77	45	20	and	and	CC
cord-017420-tjwxec77	45	21	are	be	VBP
cord-017420-tjwxec77	45	22	essential	essential	JJ
cord-017420-tjwxec77	45	23	to	to	IN
cord-017420-tjwxec77	45	24	microbial	microbial	JJ
cord-017420-tjwxec77	45	25	killing	killing	NN
cord-017420-tjwxec77	45	26	and	and	CC
cord-017420-tjwxec77	45	27	infection	infection	NN
cord-017420-tjwxec77	45	28	control	control	NN
cord-017420-tjwxec77	45	29	[	[	-LRB-
cord-017420-tjwxec77	45	30	40	40	CD
cord-017420-tjwxec77	45	31	,	,	,
cord-017420-tjwxec77	45	32	45	45	CD
cord-017420-tjwxec77	45	33	]	]	-RRB-
cord-017420-tjwxec77	45	34	.	.	.
cord-017420-tjwxec77	46	1	Neutropenic	neutropenic	JJ
cord-017420-tjwxec77	46	2	fever	fever	NN
cord-017420-tjwxec77	46	3	and	and	CC
cord-017420-tjwxec77	46	4	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	46	5	sepsis	sepsis	NN
cord-017420-tjwxec77	46	6	have	have	VBP
cord-017420-tjwxec77	46	7	historically	historically	RB
cord-017420-tjwxec77	46	8	been	be	VBN
cord-017420-tjwxec77	46	9	thought	think	VBN
cord-017420-tjwxec77	46	10	of	of	IN
cord-017420-tjwxec77	46	11	as	as	IN
cord-017420-tjwxec77	46	12	variants	variant	NNS
cord-017420-tjwxec77	46	13	of	of	IN
cord-017420-tjwxec77	46	14	non	non	JJ
cord-017420-tjwxec77	46	15	-	-	JJ
cord-017420-tjwxec77	46	16	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	46	17	fever	fever	NN
cord-017420-tjwxec77	46	18	and	and	CC
cord-017420-tjwxec77	46	19	sepsis	sepsis	NN
cord-017420-tjwxec77	46	20	,	,	,
cord-017420-tjwxec77	46	21	just	just	RB
cord-017420-tjwxec77	46	22	without	without	IN
cord-017420-tjwxec77	46	23	an	an	DT
cord-017420-tjwxec77	46	24	intact	intact	JJ
cord-017420-tjwxec77	46	25	immune	immune	JJ
cord-017420-tjwxec77	46	26	system	system	NN
cord-017420-tjwxec77	46	27	,	,	,
cord-017420-tjwxec77	46	28	akin	akin	JJ
cord-017420-tjwxec77	46	29	to	to	IN
cord-017420-tjwxec77	46	30	a	a	DT
cord-017420-tjwxec77	46	31	"	"	``
cord-017420-tjwxec77	46	32	fire	fire	NN
cord-017420-tjwxec77	46	33	without	without	IN
cord-017420-tjwxec77	46	34	firefighters	firefighter	NNS
cord-017420-tjwxec77	46	35	.	.	.
cord-017420-tjwxec77	46	36	"	"	''
cord-017420-tjwxec77	47	1	However	however	RB
cord-017420-tjwxec77	47	2	,	,	,
cord-017420-tjwxec77	47	3	increasing	increase	VBG
cord-017420-tjwxec77	47	4	data	datum	NNS
cord-017420-tjwxec77	47	5	suggest	suggest	VBP
cord-017420-tjwxec77	47	6	that	that	IN
cord-017420-tjwxec77	47	7	the	the	DT
cord-017420-tjwxec77	47	8	pathophysiology	pathophysiology	NN
cord-017420-tjwxec77	47	9	of	of	IN
cord-017420-tjwxec77	47	10	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	47	11	patients	patient	NNS
cord-017420-tjwxec77	47	12	is	be	VBZ
cord-017420-tjwxec77	47	13	much	much	RB
cord-017420-tjwxec77	47	14	more	more	RBR
cord-017420-tjwxec77	47	15	complicated	complicated	JJ
cord-017420-tjwxec77	47	16	than	than	IN
cord-017420-tjwxec77	47	17	simply	simply	RB
cord-017420-tjwxec77	47	18	an	an	DT
cord-017420-tjwxec77	47	19	uncontrolled	uncontrolled	JJ
cord-017420-tjwxec77	47	20	infection	infection	NN
cord-017420-tjwxec77	47	21	[	[	-LRB-
cord-017420-tjwxec77	47	22	36	36	CD
cord-017420-tjwxec77	47	23	]	]	-RRB-
cord-017420-tjwxec77	47	24	.	.	.
cord-017420-tjwxec77	48	1	In	in	IN
cord-017420-tjwxec77	48	2	addition	addition	NN
cord-017420-tjwxec77	48	3	to	to	IN
cord-017420-tjwxec77	48	4	their	-PRON-	PRP$
cord-017420-tjwxec77	48	5	key	key	JJ
cord-017420-tjwxec77	48	6	role	role	NN
cord-017420-tjwxec77	48	7	in	in	IN
cord-017420-tjwxec77	48	8	the	the	DT
cord-017420-tjwxec77	48	9	response	response	NN
cord-017420-tjwxec77	48	10	to	to	IN
cord-017420-tjwxec77	48	11	localized	localize	VBN
cord-017420-tjwxec77	48	12	infections	infection	NNS
cord-017420-tjwxec77	48	13	(	(	-LRB-
cord-017420-tjwxec77	48	14	e.g.	e.g.	RB
cord-017420-tjwxec77	48	15	,	,	,
cord-017420-tjwxec77	48	16	pneumonia	pneumonia	NN
cord-017420-tjwxec77	48	17	)	)	-RRB-
cord-017420-tjwxec77	48	18	,	,	,
cord-017420-tjwxec77	48	19	in	in	IN
cord-017420-tjwxec77	48	20	sepsis	sepsis	NN
cord-017420-tjwxec77	48	21	neutrophils	neutrophil	NNS
cord-017420-tjwxec77	48	22	are	be	VBP
cord-017420-tjwxec77	48	23	rapidly	rapidly	RB
cord-017420-tjwxec77	48	24	recruited	recruit	VBN
cord-017420-tjwxec77	48	25	to	to	IN
cord-017420-tjwxec77	48	26	organs	organ	NNS
cord-017420-tjwxec77	48	27	(	(	-LRB-
cord-017420-tjwxec77	48	28	lungs	lung	NNS
cord-017420-tjwxec77	48	29	,	,	,
cord-017420-tjwxec77	48	30	kidneys	kidney	NNS
cord-017420-tjwxec77	48	31	,	,	,
cord-017420-tjwxec77	48	32	liver	liver	NN
cord-017420-tjwxec77	48	33	)	)	-RRB-
cord-017420-tjwxec77	48	34	and	and	CC
cord-017420-tjwxec77	48	35	are	be	VBP
cord-017420-tjwxec77	48	36	thought	think	VBN
cord-017420-tjwxec77	48	37	to	to	TO
cord-017420-tjwxec77	48	38	contribute	contribute	VB
cord-017420-tjwxec77	48	39	to	to	IN
cord-017420-tjwxec77	48	40	tissue	tissue	NN
cord-017420-tjwxec77	48	41	damage	damage	NN
cord-017420-tjwxec77	48	42	and	and	CC
cord-017420-tjwxec77	48	43	organ	organ	NN
cord-017420-tjwxec77	48	44	dysfunction	dysfunction	NN
cord-017420-tjwxec77	48	45	[	[	-LRB-
cord-017420-tjwxec77	48	46	45	45	CD
cord-017420-tjwxec77	48	47	]	]	-RRB-
cord-017420-tjwxec77	48	48	.	.	.
cord-017420-tjwxec77	49	1	Neutrophils	neutrophils	NN
cord-017420-tjwxec77	49	2	also	also	RB
cord-017420-tjwxec77	49	3	contribute	contribute	VBP
cord-017420-tjwxec77	49	4	to	to	IN
cord-017420-tjwxec77	49	5	resolution	resolution	NN
cord-017420-tjwxec77	49	6	of	of	IN
cord-017420-tjwxec77	49	7	injury	injury	NN
cord-017420-tjwxec77	49	8	and	and	CC
cord-017420-tjwxec77	49	9	tissue	tissue	NN
cord-017420-tjwxec77	49	10	repair	repair	NN
cord-017420-tjwxec77	49	11	[	[	-LRB-
cord-017420-tjwxec77	49	12	36	36	CD
cord-017420-tjwxec77	49	13	]	]	-RRB-
cord-017420-tjwxec77	49	14	,	,	,
cord-017420-tjwxec77	49	15	as	as	RB
cord-017420-tjwxec77	49	16	well	well	RB
cord-017420-tjwxec77	49	17	as	as	IN
cord-017420-tjwxec77	49	18	regulation	regulation	NN
cord-017420-tjwxec77	49	19	of	of	IN
cord-017420-tjwxec77	49	20	the	the	DT
cord-017420-tjwxec77	49	21	adaptive	adaptive	JJ
cord-017420-tjwxec77	49	22	immune	immune	JJ
cord-017420-tjwxec77	49	23	response	response	NN
cord-017420-tjwxec77	49	24	[	[	-LRB-
cord-017420-tjwxec77	49	25	40	40	CD
cord-017420-tjwxec77	49	26	,	,	,
cord-017420-tjwxec77	49	27	76	76	CD
cord-017420-tjwxec77	49	28	]	]	-RRB-
cord-017420-tjwxec77	49	29	.	.	.
cord-017420-tjwxec77	50	1	Thus	thus	RB
cord-017420-tjwxec77	50	2	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	50	3	patients	patient	NNS
cord-017420-tjwxec77	50	4	are	be	VBP
cord-017420-tjwxec77	50	5	not	not	RB
cord-017420-tjwxec77	50	6	only	only	RB
cord-017420-tjwxec77	50	7	deficient	deficient	JJ
cord-017420-tjwxec77	50	8	in	in	IN
cord-017420-tjwxec77	50	9	the	the	DT
cord-017420-tjwxec77	50	10	immediate	immediate	JJ
cord-017420-tjwxec77	50	11	response	response	NN
cord-017420-tjwxec77	50	12	to	to	IN
cord-017420-tjwxec77	50	13	infection	infection	NN
cord-017420-tjwxec77	50	14	but	but	CC
cord-017420-tjwxec77	50	15	also	also	RB
cord-017420-tjwxec77	50	16	have	have	VBP
cord-017420-tjwxec77	50	17	an	an	DT
cord-017420-tjwxec77	50	18	altered	altered	JJ
cord-017420-tjwxec77	50	19	physiology	physiology	NN
cord-017420-tjwxec77	50	20	regarding	regard	VBG
cord-017420-tjwxec77	50	21	the	the	DT
cord-017420-tjwxec77	50	22	development	development	NN
cord-017420-tjwxec77	50	23	of	of	IN
cord-017420-tjwxec77	50	24	systemic	systemic	JJ
cord-017420-tjwxec77	50	25	inflammation	inflammation	NN
cord-017420-tjwxec77	50	26	and	and	CC
cord-017420-tjwxec77	50	27	sepsis	sepsis	NN
cord-017420-tjwxec77	50	28	and	and	CC
cord-017420-tjwxec77	50	29	in	in	IN
cord-017420-tjwxec77	50	30	the	the	DT
cord-017420-tjwxec77	50	31	regulation	regulation	NN
cord-017420-tjwxec77	50	32	of	of	IN
cord-017420-tjwxec77	50	33	the	the	DT
cord-017420-tjwxec77	50	34	immune	immune	JJ
cord-017420-tjwxec77	50	35	response	response	NN
cord-017420-tjwxec77	50	36	to	to	IN
cord-017420-tjwxec77	50	37	injury	injury	NN
cord-017420-tjwxec77	50	38	and	and	CC
cord-017420-tjwxec77	50	39	tissue	tissue	NN
cord-017420-tjwxec77	50	40	repair	repair	NN
cord-017420-tjwxec77	50	41	.	.	.
cord-017420-tjwxec77	51	1	It	-PRON-	PRP
cord-017420-tjwxec77	51	2	is	be	VBZ
cord-017420-tjwxec77	51	3	increasingly	increasingly	RB
cord-017420-tjwxec77	51	4	unclear	unclear	JJ
cord-017420-tjwxec77	51	5	whether	whether	IN
cord-017420-tjwxec77	51	6	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	51	7	sepsis	sepsis	NN
cord-017420-tjwxec77	51	8	(	(	-LRB-
cord-017420-tjwxec77	51	9	and	and	CC
cord-017420-tjwxec77	51	10	the	the	DT
cord-017420-tjwxec77	51	11	organ	organ	NN
cord-017420-tjwxec77	51	12	damage	damage	NN
cord-017420-tjwxec77	51	13	sequelae	sequela	NNS
cord-017420-tjwxec77	51	14	)	)	-RRB-
cord-017420-tjwxec77	51	15	is	be	VBZ
cord-017420-tjwxec77	51	16	the	the	DT
cord-017420-tjwxec77	51	17	same	same	JJ
cord-017420-tjwxec77	51	18	disease	disease	NN
cord-017420-tjwxec77	51	19	as	as	IN
cord-017420-tjwxec77	51	20	non	non	JJ
cord-017420-tjwxec77	51	21	-	-	JJ
cord-017420-tjwxec77	51	22	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	51	23	sepsis	sepsis	NN
cord-017420-tjwxec77	51	24	.	.	.
cord-017420-tjwxec77	52	1	Because	because	IN
cord-017420-tjwxec77	52	2	cytotoxic	cytotoxic	JJ
cord-017420-tjwxec77	52	3	chemotherapy	chemotherapy	NN
cord-017420-tjwxec77	52	4	is	be	VBZ
cord-017420-tjwxec77	52	5	not	not	RB
cord-017420-tjwxec77	52	6	selective	selective	JJ
cord-017420-tjwxec77	52	7	,	,	,
cord-017420-tjwxec77	52	8	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	52	9	patients	patient	NNS
cord-017420-tjwxec77	52	10	are	be	VBP
cord-017420-tjwxec77	52	11	also	also	RB
cord-017420-tjwxec77	52	12	lymphopenic	lymphopenic	JJ
cord-017420-tjwxec77	52	13	,	,	,
cord-017420-tjwxec77	52	14	thrombocytopenic	thrombocytopenic	JJ
cord-017420-tjwxec77	52	15	,	,	,
cord-017420-tjwxec77	52	16	and	and	CC
cord-017420-tjwxec77	52	17	anemic	anemic	JJ
cord-017420-tjwxec77	52	18	.	.	.
cord-017420-tjwxec77	53	1	Lymphocytes	lymphocyte	NNS
cord-017420-tjwxec77	53	2	,	,	,
cord-017420-tjwxec77	53	3	including	include	VBG
cord-017420-tjwxec77	53	4	T	t	NN
cord-017420-tjwxec77	53	5	cells	cell	NNS
cord-017420-tjwxec77	53	6	,	,	,
cord-017420-tjwxec77	53	7	B	b	NN
cord-017420-tjwxec77	53	8	cells	cell	NNS
cord-017420-tjwxec77	53	9	,	,	,
cord-017420-tjwxec77	53	10	and	and	CC
cord-017420-tjwxec77	53	11	natural	natural	JJ
cord-017420-tjwxec77	53	12	killer	killer	NN
cord-017420-tjwxec77	53	13	(	(	-LRB-
cord-017420-tjwxec77	53	14	NK	NK	NNP
cord-017420-tjwxec77	53	15	)	)	-RRB-
cord-017420-tjwxec77	53	16	cells	cell	NNS
cord-017420-tjwxec77	53	17	,	,	,
cord-017420-tjwxec77	53	18	have	have	VBP
cord-017420-tjwxec77	53	19	protean	protean	JJ
cord-017420-tjwxec77	53	20	roles	role	NNS
cord-017420-tjwxec77	53	21	in	in	IN
cord-017420-tjwxec77	53	22	the	the	DT
cord-017420-tjwxec77	53	23	immune	immune	JJ
cord-017420-tjwxec77	53	24	system	system	NN
cord-017420-tjwxec77	53	25	and	and	CC
cord-017420-tjwxec77	53	26	a	a	DT
cord-017420-tjwxec77	53	27	broad	broad	JJ
cord-017420-tjwxec77	53	28	effect	effect	NN
cord-017420-tjwxec77	53	29	on	on	IN
cord-017420-tjwxec77	53	30	the	the	DT
cord-017420-tjwxec77	53	31	response	response	NN
cord-017420-tjwxec77	53	32	to	to	IN
cord-017420-tjwxec77	53	33	infection	infection	NN
cord-017420-tjwxec77	53	34	and	and	CC
cord-017420-tjwxec77	53	35	septic	septic	JJ
cord-017420-tjwxec77	53	36	physiology	physiology	NN
cord-017420-tjwxec77	53	37	[	[	-LRB-
cord-017420-tjwxec77	53	38	20	20	CD
cord-017420-tjwxec77	53	39	,	,	,
cord-017420-tjwxec77	53	40	43	43	CD
cord-017420-tjwxec77	53	41	]	]	-RRB-
cord-017420-tjwxec77	53	42	.	.	.
cord-017420-tjwxec77	54	1	These	these	DT
cord-017420-tjwxec77	54	2	cells	cell	NNS
cord-017420-tjwxec77	54	3	are	be	VBP
cord-017420-tjwxec77	54	4	also	also	RB
cord-017420-tjwxec77	54	5	drastically	drastically	RB
cord-017420-tjwxec77	54	6	reduced	reduce	VBN
cord-017420-tjwxec77	54	7	after	after	IN
cord-017420-tjwxec77	54	8	cytotoxic	cytotoxic	JJ
cord-017420-tjwxec77	54	9	chemotherapy	chemotherapy	NN
cord-017420-tjwxec77	54	10	,	,	,
cord-017420-tjwxec77	54	11	and	and	CC
cord-017420-tjwxec77	54	12	lymphopenia	lymphopenia	NNP
cord-017420-tjwxec77	54	13	has	have	VBZ
cord-017420-tjwxec77	54	14	been	be	VBN
cord-017420-tjwxec77	54	15	associated	associate	VBN
cord-017420-tjwxec77	54	16	with	with	IN
cord-017420-tjwxec77	54	17	an	an	DT
cord-017420-tjwxec77	54	18	increased	increase	VBN
cord-017420-tjwxec77	54	19	risk	risk	NN
cord-017420-tjwxec77	54	20	of	of	IN
cord-017420-tjwxec77	54	21	death	death	NN
cord-017420-tjwxec77	54	22	[	[	-LRB-
cord-017420-tjwxec77	54	23	67	67	CD
cord-017420-tjwxec77	54	24	,	,	,
cord-017420-tjwxec77	54	25	71	71	CD
cord-017420-tjwxec77	54	26	]	]	-RRB-
cord-017420-tjwxec77	54	27	.	.	.
cord-017420-tjwxec77	55	1	Adding	add	VBG
cord-017420-tjwxec77	55	2	to	to	IN
cord-017420-tjwxec77	55	3	the	the	DT
cord-017420-tjwxec77	55	4	complexity	complexity	NN
cord-017420-tjwxec77	55	5	,	,	,
cord-017420-tjwxec77	55	6	the	the	DT
cord-017420-tjwxec77	55	7	kinetics	kinetic	NNS
cord-017420-tjwxec77	55	8	of	of	IN
cord-017420-tjwxec77	55	9	count	count	NN
cord-017420-tjwxec77	55	10	recovery	recovery	NN
cord-017420-tjwxec77	55	11	and	and	CC
cord-017420-tjwxec77	55	12	engraftment	engraftment	NN
cord-017420-tjwxec77	55	13	vary	vary	VBP
cord-017420-tjwxec77	55	14	,	,	,
cord-017420-tjwxec77	55	15	and	and	CC
cord-017420-tjwxec77	55	16	reconstitution	reconstitution	NN
cord-017420-tjwxec77	55	17	of	of	IN
cord-017420-tjwxec77	55	18	all	all	DT
cord-017420-tjwxec77	55	19	cell	cell	NN
cord-017420-tjwxec77	55	20	lines	line	NNS
cord-017420-tjwxec77	55	21	does	do	VBZ
cord-017420-tjwxec77	55	22	not	not	RB
cord-017420-tjwxec77	55	23	happen	happen	VB
cord-017420-tjwxec77	55	24	simultaneously	simultaneously	RB
cord-017420-tjwxec77	55	25	[	[	-LRB-
cord-017420-tjwxec77	55	26	11	11	CD
cord-017420-tjwxec77	55	27	]	]	-RRB-
cord-017420-tjwxec77	55	28	.	.	.
cord-017420-tjwxec77	56	1	Though	though	IN
cord-017420-tjwxec77	56	2	the	the	DT
cord-017420-tjwxec77	56	3	total	total	JJ
cord-017420-tjwxec77	56	4	effect	effect	NN
cord-017420-tjwxec77	56	5	of	of	IN
cord-017420-tjwxec77	56	6	lymphopenia	lymphopenia	NNP
cord-017420-tjwxec77	56	7	on	on	IN
cord-017420-tjwxec77	56	8	the	the	DT
cord-017420-tjwxec77	56	9	pathophysiology	pathophysiology	NN
cord-017420-tjwxec77	56	10	of	of	IN
cord-017420-tjwxec77	56	11	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	56	12	fever	fever	NN
cord-017420-tjwxec77	56	13	and	and	CC
cord-017420-tjwxec77	56	14	infection	infection	NN
cord-017420-tjwxec77	56	15	remains	remain	VBZ
cord-017420-tjwxec77	56	16	to	to	TO
cord-017420-tjwxec77	56	17	be	be	VB
cord-017420-tjwxec77	56	18	fully	fully	RB
cord-017420-tjwxec77	56	19	determined	determine	VBN
cord-017420-tjwxec77	56	20	,	,	,
cord-017420-tjwxec77	56	21	patients	patient	NNS
cord-017420-tjwxec77	56	22	with	with	IN
cord-017420-tjwxec77	56	23	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	56	24	sepsis	sepsis	NN
cord-017420-tjwxec77	56	25	have	have	VBP
cord-017420-tjwxec77	56	26	different	different	JJ
cord-017420-tjwxec77	56	27	cytokine	cytokine	NN
cord-017420-tjwxec77	56	28	profiles	profile	NNS
cord-017420-tjwxec77	56	29	than	than	IN
cord-017420-tjwxec77	56	30	patients	patient	NNS
cord-017420-tjwxec77	56	31	with	with	IN
cord-017420-tjwxec77	56	32	non	non	JJ
cord-017420-tjwxec77	56	33	-	-	JJ
cord-017420-tjwxec77	56	34	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	56	35	sepsis	sepsis	NN
cord-017420-tjwxec77	56	36	:	:	:
cord-017420-tjwxec77	56	37	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	56	38	patients	patient	NNS
cord-017420-tjwxec77	56	39	have	have	VBP
cord-017420-tjwxec77	56	40	higher	high	JJR
cord-017420-tjwxec77	56	41	levels	level	NNS
cord-017420-tjwxec77	56	42	of	of	IN
cord-017420-tjwxec77	56	43	IL-6	IL-6	NNP
cord-017420-tjwxec77	56	44	,	,	,
cord-017420-tjwxec77	56	45	IL-8	IL-8	NNP
cord-017420-tjwxec77	56	46	,	,	,
cord-017420-tjwxec77	56	47	and	and	CC
cord-017420-tjwxec77	56	48	G	G	NNP
cord-017420-tjwxec77	56	49	-	-	HYPH
cord-017420-tjwxec77	56	50	CSF	CSF	NNP
cord-017420-tjwxec77	56	51	than	than	IN
cord-017420-tjwxec77	56	52	non	non	JJ
cord-017420-tjwxec77	56	53	-	-	JJ
cord-017420-tjwxec77	56	54	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	56	55	patients	patient	NNS
cord-017420-tjwxec77	56	56	[	[	-LRB-
cord-017420-tjwxec77	56	57	60	60	CD
cord-017420-tjwxec77	56	58	]	]	-RRB-
cord-017420-tjwxec77	56	59	.	.	.
cord-017420-tjwxec77	57	1	Monocytes	monocyte	NNS
cord-017420-tjwxec77	57	2	are	be	VBP
cord-017420-tjwxec77	57	3	also	also	RB
cord-017420-tjwxec77	57	4	dysfunctional	dysfunctional	JJ
cord-017420-tjwxec77	57	5	in	in	IN
cord-017420-tjwxec77	57	6	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	57	7	sepsis	sepsis	NN
cord-017420-tjwxec77	57	8	,	,	,
cord-017420-tjwxec77	57	9	with	with	IN
cord-017420-tjwxec77	57	10	evidence	evidence	NN
cord-017420-tjwxec77	57	11	not	not	RB
cord-017420-tjwxec77	57	12	only	only	RB
cord-017420-tjwxec77	57	13	of	of	IN
cord-017420-tjwxec77	57	14	deactivation	deactivation	NN
cord-017420-tjwxec77	57	15	of	of	IN
cord-017420-tjwxec77	57	16	monocytes	monocyte	NNS
cord-017420-tjwxec77	57	17	in	in	IN
cord-017420-tjwxec77	57	18	peripheral	peripheral	JJ
cord-017420-tjwxec77	57	19	blood	blood	NN
cord-017420-tjwxec77	57	20	but	but	CC
cord-017420-tjwxec77	57	21	also	also	RB
cord-017420-tjwxec77	57	22	of	of	IN
cord-017420-tjwxec77	57	23	deactivation	deactivation	NN
cord-017420-tjwxec77	57	24	of	of	IN
cord-017420-tjwxec77	57	25	differentiated	differentiated	JJ
cord-017420-tjwxec77	57	26	pulmonary	pulmonary	JJ
cord-017420-tjwxec77	57	27	macrophages	macrophage	NNS
cord-017420-tjwxec77	57	28	in	in	IN
cord-017420-tjwxec77	57	29	patients	patient	NNS
cord-017420-tjwxec77	57	30	with	with	IN
cord-017420-tjwxec77	57	31	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	57	32	sepsis	sepsis	NN
cord-017420-tjwxec77	57	33	[	[	-LRB-
cord-017420-tjwxec77	57	34	48	48	CD
cord-017420-tjwxec77	57	35	,	,	,
cord-017420-tjwxec77	57	36	49	49	CD
cord-017420-tjwxec77	57	37	]	]	-RRB-
cord-017420-tjwxec77	57	38	.	.	.
cord-017420-tjwxec77	58	1	The	the	DT
cord-017420-tjwxec77	58	2	implications	implication	NNS
cord-017420-tjwxec77	58	3	of	of	IN
cord-017420-tjwxec77	58	4	pancytopenia	pancytopenia	NNP
cord-017420-tjwxec77	58	5	for	for	IN
cord-017420-tjwxec77	58	6	the	the	DT
cord-017420-tjwxec77	58	7	response	response	NN
cord-017420-tjwxec77	58	8	to	to	IN
cord-017420-tjwxec77	58	9	infection	infection	NN
cord-017420-tjwxec77	58	10	extend	extend	VBP
cord-017420-tjwxec77	58	11	beyond	beyond	IN
cord-017420-tjwxec77	58	12	white	white	JJ
cord-017420-tjwxec77	58	13	blood	blood	NN
cord-017420-tjwxec77	58	14	cells	cell	NNS
cord-017420-tjwxec77	58	15	.	.	.
cord-017420-tjwxec77	59	1	Most	Most	JJS
cord-017420-tjwxec77	59	2	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	59	3	patients	patient	NNS
cord-017420-tjwxec77	59	4	are	be	VBP
cord-017420-tjwxec77	59	5	thrombocytopenic	thrombocytopenic	JJ
cord-017420-tjwxec77	59	6	,	,	,
cord-017420-tjwxec77	59	7	and	and	CC
cord-017420-tjwxec77	59	8	platelets	platelet	NNS
cord-017420-tjwxec77	59	9	are	be	VBP
cord-017420-tjwxec77	59	10	increasingly	increasingly	RB
cord-017420-tjwxec77	59	11	recognized	recognize	VBN
cord-017420-tjwxec77	59	12	to	to	TO
cord-017420-tjwxec77	59	13	play	play	VB
cord-017420-tjwxec77	59	14	an	an	DT
cord-017420-tjwxec77	59	15	important	important	JJ
cord-017420-tjwxec77	59	16	role	role	NN
cord-017420-tjwxec77	59	17	in	in	IN
cord-017420-tjwxec77	59	18	the	the	DT
cord-017420-tjwxec77	59	19	immune	immune	JJ
cord-017420-tjwxec77	59	20	response	response	NN
cord-017420-tjwxec77	59	21	[	[	-LRB-
cord-017420-tjwxec77	59	22	23	23	CD
cord-017420-tjwxec77	59	23	,	,	,
cord-017420-tjwxec77	59	24	74	74	CD
cord-017420-tjwxec77	59	25	]	]	-RRB-
cord-017420-tjwxec77	59	26	.	.	.
cord-017420-tjwxec77	60	1	Thrombocytopenia	Thrombocytopenia	NNP
cord-017420-tjwxec77	60	2	is	be	VBZ
cord-017420-tjwxec77	60	3	associated	associate	VBN
cord-017420-tjwxec77	60	4	with	with	IN
cord-017420-tjwxec77	60	5	poor	poor	JJ
cord-017420-tjwxec77	60	6	outcomes	outcome	NNS
cord-017420-tjwxec77	60	7	in	in	IN
cord-017420-tjwxec77	60	8	critical	critical	JJ
cord-017420-tjwxec77	60	9	illness	illness	NN
cord-017420-tjwxec77	60	10	,	,	,
cord-017420-tjwxec77	60	11	including	include	VBG
cord-017420-tjwxec77	60	12	in	in	IN
cord-017420-tjwxec77	60	13	sepsis	sepsis	NN
cord-017420-tjwxec77	60	14	[	[	-LRB-
cord-017420-tjwxec77	60	15	18	18	CD
cord-017420-tjwxec77	60	16	]	]	-RRB-
cord-017420-tjwxec77	60	17	.	.	.
cord-017420-tjwxec77	61	1	In	in	IN
cord-017420-tjwxec77	61	2	addition	addition	NN
cord-017420-tjwxec77	61	3	to	to	IN
cord-017420-tjwxec77	61	4	secreting	secrete	VBG
cord-017420-tjwxec77	61	5	mediators	mediator	NNS
cord-017420-tjwxec77	61	6	and	and	CC
cord-017420-tjwxec77	61	7	regulators	regulator	NNS
cord-017420-tjwxec77	61	8	of	of	IN
cord-017420-tjwxec77	61	9	inflammation	inflammation	NN
cord-017420-tjwxec77	61	10	,	,	,
cord-017420-tjwxec77	61	11	platelets	platelet	NNS
cord-017420-tjwxec77	61	12	interact	interact	VBP
cord-017420-tjwxec77	61	13	with	with	IN
cord-017420-tjwxec77	61	14	neutrophils	neutrophil	NNS
cord-017420-tjwxec77	61	15	and	and	CC
cord-017420-tjwxec77	61	16	monocytes	monocyte	NNS
cord-017420-tjwxec77	61	17	and	and	CC
cord-017420-tjwxec77	61	18	play	play	VB
cord-017420-tjwxec77	61	19	a	a	DT
cord-017420-tjwxec77	61	20	vital	vital	JJ
cord-017420-tjwxec77	61	21	role	role	NN
cord-017420-tjwxec77	61	22	in	in	IN
cord-017420-tjwxec77	61	23	the	the	DT
cord-017420-tjwxec77	61	24	defense	defense	NN
cord-017420-tjwxec77	61	25	against	against	IN
cord-017420-tjwxec77	61	26	bacterial	bacterial	JJ
cord-017420-tjwxec77	61	27	,	,	,
cord-017420-tjwxec77	61	28	viral	viral	JJ
cord-017420-tjwxec77	61	29	,	,	,
cord-017420-tjwxec77	61	30	and	and	CC
cord-017420-tjwxec77	61	31	fungal	fungal	JJ
cord-017420-tjwxec77	61	32	infections	infection	NNS
cord-017420-tjwxec77	61	33	via	via	IN
cord-017420-tjwxec77	61	34	the	the	DT
cord-017420-tjwxec77	61	35	formation	formation	NN
cord-017420-tjwxec77	61	36	of	of	IN
cord-017420-tjwxec77	61	37	neutrophil	neutrophil	NN
cord-017420-tjwxec77	61	38	extracellular	extracellular	JJ
cord-017420-tjwxec77	61	39	traps	trap	NNS
cord-017420-tjwxec77	61	40	(	(	-LRB-
cord-017420-tjwxec77	61	41	NETs	nets	NN
cord-017420-tjwxec77	61	42	)	)	-RRB-
cord-017420-tjwxec77	61	43	[	[	-LRB-
cord-017420-tjwxec77	61	44	16	16	CD
cord-017420-tjwxec77	61	45	,	,	,
cord-017420-tjwxec77	61	46	21	21	CD
cord-017420-tjwxec77	61	47	,	,	,
cord-017420-tjwxec77	61	48	23	23	CD
cord-017420-tjwxec77	61	49	]	]	-RRB-
cord-017420-tjwxec77	61	50	.	.	.
cord-017420-tjwxec77	62	1	Platelets	platelet	NNS
cord-017420-tjwxec77	62	2	also	also	RB
cord-017420-tjwxec77	62	3	play	play	VBP
cord-017420-tjwxec77	62	4	roles	role	NNS
cord-017420-tjwxec77	62	5	in	in	IN
cord-017420-tjwxec77	62	6	the	the	DT
cord-017420-tjwxec77	62	7	development	development	NN
cord-017420-tjwxec77	62	8	and	and	CC
cord-017420-tjwxec77	62	9	resolution	resolution	NN
cord-017420-tjwxec77	62	10	of	of	IN
cord-017420-tjwxec77	62	11	organ	organ	NN
cord-017420-tjwxec77	62	12	failure	failure	NN
cord-017420-tjwxec77	62	13	in	in	IN
cord-017420-tjwxec77	62	14	inflammatory	inflammatory	JJ
cord-017420-tjwxec77	62	15	states	state	NNS
cord-017420-tjwxec77	62	16	,	,	,
cord-017420-tjwxec77	62	17	including	include	VBG
cord-017420-tjwxec77	62	18	sepsis	sepsis	NN
cord-017420-tjwxec77	62	19	.	.	.
cord-017420-tjwxec77	63	1	In	in	IN
cord-017420-tjwxec77	63	2	particular	particular	JJ
cord-017420-tjwxec77	63	3	,	,	,
cord-017420-tjwxec77	63	4	thrombocytopenia	thrombocytopenia	NN
cord-017420-tjwxec77	63	5	has	have	VBZ
cord-017420-tjwxec77	63	6	been	be	VBN
cord-017420-tjwxec77	63	7	demonstrated	demonstrate	VBN
cord-017420-tjwxec77	63	8	to	to	TO
cord-017420-tjwxec77	63	9	potentiate	potentiate	VB
cord-017420-tjwxec77	63	10	lung	lung	NN
cord-017420-tjwxec77	63	11	injury	injury	NN
cord-017420-tjwxec77	63	12	[	[	-LRB-
cord-017420-tjwxec77	63	13	46	46	CD
cord-017420-tjwxec77	63	14	,	,	,
cord-017420-tjwxec77	63	15	86	86	CD
cord-017420-tjwxec77	63	16	]	]	-RRB-
cord-017420-tjwxec77	63	17	,	,	,
cord-017420-tjwxec77	63	18	and	and	CC
cord-017420-tjwxec77	63	19	platelets	platelet	NNS
cord-017420-tjwxec77	63	20	may	may	MD
cord-017420-tjwxec77	63	21	play	play	VB
cord-017420-tjwxec77	63	22	a	a	DT
cord-017420-tjwxec77	63	23	role	role	NN
cord-017420-tjwxec77	63	24	in	in	IN
cord-017420-tjwxec77	63	25	the	the	DT
cord-017420-tjwxec77	63	26	pathophysiology	pathophysiology	NN
cord-017420-tjwxec77	63	27	of	of	IN
cord-017420-tjwxec77	63	28	acute	acute	JJ
cord-017420-tjwxec77	63	29	kidney	kidney	NN
cord-017420-tjwxec77	63	30	injury	injury	NN
cord-017420-tjwxec77	63	31	[	[	-LRB-
cord-017420-tjwxec77	63	32	23	23	CD
cord-017420-tjwxec77	63	33	]	]	-RRB-
cord-017420-tjwxec77	63	34	.	.	.
cord-017420-tjwxec77	64	1	While	while	IN
cord-017420-tjwxec77	64	2	the	the	DT
cord-017420-tjwxec77	64	3	role	role	NN
cord-017420-tjwxec77	64	4	of	of	IN
cord-017420-tjwxec77	64	5	thrombocytopenia	thrombocytopenia	NN
cord-017420-tjwxec77	64	6	in	in	IN
cord-017420-tjwxec77	64	7	infection	infection	NN
cord-017420-tjwxec77	64	8	remains	remain	VBZ
cord-017420-tjwxec77	64	9	incompletely	incompletely	RB
cord-017420-tjwxec77	64	10	elucidated	elucidate	VBN
cord-017420-tjwxec77	64	11	,	,	,
cord-017420-tjwxec77	64	12	it	-PRON-	PRP
cord-017420-tjwxec77	64	13	seems	seem	VBZ
cord-017420-tjwxec77	64	14	clear	clear	JJ
cord-017420-tjwxec77	64	15	that	that	IN
cord-017420-tjwxec77	64	16	[	[	-LRB-
cord-017420-tjwxec77	64	17	70	70	CD
cord-017420-tjwxec77	64	18	]	]	-RRB-
cord-017420-tjwxec77	64	19	thrombocytopenia	thrombocytopenia	NN
cord-017420-tjwxec77	64	20	is	be	VBZ
cord-017420-tjwxec77	64	21	an	an	DT
cord-017420-tjwxec77	64	22	important	important	JJ
cord-017420-tjwxec77	64	23	factor	factor	NN
cord-017420-tjwxec77	64	24	in	in	IN
cord-017420-tjwxec77	64	25	the	the	DT
cord-017420-tjwxec77	64	26	pathophysiology	pathophysiology	NN
cord-017420-tjwxec77	64	27	of	of	IN
cord-017420-tjwxec77	64	28	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	64	29	infection	infection	NN
cord-017420-tjwxec77	64	30	.	.	.
cord-017420-tjwxec77	65	1	Other	other	JJ
cord-017420-tjwxec77	65	2	organ	organ	NN
cord-017420-tjwxec77	65	3	systems	system	NNS
cord-017420-tjwxec77	65	4	with	with	IN
cord-017420-tjwxec77	65	5	relevance	relevance	NN
cord-017420-tjwxec77	65	6	to	to	IN
cord-017420-tjwxec77	65	7	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	65	8	infections	infection	NNS
cord-017420-tjwxec77	65	9	are	be	VBP
cord-017420-tjwxec77	65	10	also	also	RB
cord-017420-tjwxec77	65	11	affected	affect	VBN
cord-017420-tjwxec77	65	12	by	by	IN
cord-017420-tjwxec77	65	13	cytotoxic	cytotoxic	JJ
cord-017420-tjwxec77	65	14	chemotherapy	chemotherapy	NN
cord-017420-tjwxec77	65	15	.	.	.
cord-017420-tjwxec77	66	1	The	the	DT
cord-017420-tjwxec77	66	2	most	most	RBS
cord-017420-tjwxec77	66	3	important	important	JJ
cord-017420-tjwxec77	66	4	of	of	IN
cord-017420-tjwxec77	66	5	these	these	DT
cord-017420-tjwxec77	66	6	is	be	VBZ
cord-017420-tjwxec77	66	7	injury	injury	NN
cord-017420-tjwxec77	66	8	to	to	IN
cord-017420-tjwxec77	66	9	the	the	DT
cord-017420-tjwxec77	66	10	mucosal	mucosal	JJ
cord-017420-tjwxec77	66	11	barrier	barrier	NN
cord-017420-tjwxec77	66	12	of	of	IN
cord-017420-tjwxec77	66	13	the	the	DT
cord-017420-tjwxec77	66	14	intestinal	intestinal	JJ
cord-017420-tjwxec77	66	15	tract	tract	NN
cord-017420-tjwxec77	66	16	[	[	-LRB-
cord-017420-tjwxec77	66	17	13	13	CD
cord-017420-tjwxec77	66	18	,	,	,
cord-017420-tjwxec77	66	19	14	14	CD
cord-017420-tjwxec77	66	20	,	,	,
cord-017420-tjwxec77	66	21	78	78	CD
cord-017420-tjwxec77	66	22	]	]	-RRB-
cord-017420-tjwxec77	66	23	.	.	.
cord-017420-tjwxec77	67	1	Disruption	disruption	NN
cord-017420-tjwxec77	67	2	of	of	IN
cord-017420-tjwxec77	67	3	this	this	DT
cord-017420-tjwxec77	67	4	barrier	barrier	NN
cord-017420-tjwxec77	67	5	,	,	,
cord-017420-tjwxec77	67	6	which	which	WDT
cord-017420-tjwxec77	67	7	can	can	MD
cord-017420-tjwxec77	67	8	occur	occur	VB
cord-017420-tjwxec77	67	9	throughout	throughout	IN
cord-017420-tjwxec77	67	10	the	the	DT
cord-017420-tjwxec77	67	11	gastrointestinal	gastrointestinal	JJ
cord-017420-tjwxec77	67	12	(	(	-LRB-
cord-017420-tjwxec77	67	13	GI	GI	NNP
cord-017420-tjwxec77	67	14	)	)	-RRB-
cord-017420-tjwxec77	67	15	tract	tract	NN
cord-017420-tjwxec77	67	16	,	,	,
cord-017420-tjwxec77	67	17	creates	create	VBZ
cord-017420-tjwxec77	67	18	portals	portal	NNS
cord-017420-tjwxec77	67	19	through	through	IN
cord-017420-tjwxec77	67	20	which	which	WDT
cord-017420-tjwxec77	67	21	enteric	enteric	JJ
cord-017420-tjwxec77	67	22	pathogens	pathogen	NNS
cord-017420-tjwxec77	67	23	,	,	,
cord-017420-tjwxec77	67	24	including	include	VBG
cord-017420-tjwxec77	67	25	bacteria	bacteria	NNS
cord-017420-tjwxec77	67	26	and	and	CC
cord-017420-tjwxec77	67	27	yeast	yeast	NN
cord-017420-tjwxec77	67	28	,	,	,
cord-017420-tjwxec77	67	29	can	can	MD
cord-017420-tjwxec77	67	30	enter	enter	VB
cord-017420-tjwxec77	67	31	the	the	DT
cord-017420-tjwxec77	67	32	bloodstream	bloodstream	NN
cord-017420-tjwxec77	67	33	.	.	.
cord-017420-tjwxec77	68	1	This	this	DT
cord-017420-tjwxec77	68	2	is	be	VBZ
cord-017420-tjwxec77	68	3	an	an	DT
cord-017420-tjwxec77	68	4	important	important	JJ
cord-017420-tjwxec77	68	5	source	source	NN
cord-017420-tjwxec77	68	6	of	of	IN
cord-017420-tjwxec77	68	7	gram	gram	NN
cord-017420-tjwxec77	68	8	-	-	HYPH
cord-017420-tjwxec77	68	9	positive	positive	JJ
cord-017420-tjwxec77	68	10	,	,	,
cord-017420-tjwxec77	68	11	gram	gram	NN
cord-017420-tjwxec77	68	12	-	-	HYPH
cord-017420-tjwxec77	68	13	negative	negative	JJ
cord-017420-tjwxec77	68	14	,	,	,
cord-017420-tjwxec77	68	15	and	and	CC
cord-017420-tjwxec77	68	16	fungal	fungal	JJ
cord-017420-tjwxec77	68	17	infections	infection	NNS
cord-017420-tjwxec77	68	18	in	in	IN
cord-017420-tjwxec77	68	19	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	68	20	patients	patient	NNS
cord-017420-tjwxec77	68	21	.	.	.
cord-017420-tjwxec77	69	1	The	the	DT
cord-017420-tjwxec77	69	2	respiratory	respiratory	JJ
cord-017420-tjwxec77	69	3	system	system	NN
cord-017420-tjwxec77	69	4	is	be	VBZ
cord-017420-tjwxec77	69	5	also	also	RB
cord-017420-tjwxec77	69	6	affected	affect	VBN
cord-017420-tjwxec77	69	7	in	in	IN
cord-017420-tjwxec77	69	8	neutropenia	neutropenia	NN
cord-017420-tjwxec77	69	9	.	.	.
cord-017420-tjwxec77	70	1	Not	not	RB
cord-017420-tjwxec77	70	2	only	only	RB
cord-017420-tjwxec77	70	3	are	be	VBP
cord-017420-tjwxec77	70	4	pulmonary	pulmonary	JJ
cord-017420-tjwxec77	70	5	macrophages	macrophage	NNS
cord-017420-tjwxec77	70	6	known	know	VBN
cord-017420-tjwxec77	70	7	to	to	TO
cord-017420-tjwxec77	70	8	be	be	VB
cord-017420-tjwxec77	70	9	qualitatively	qualitatively	RB
cord-017420-tjwxec77	70	10	dysfunctional	dysfunctional	JJ
cord-017420-tjwxec77	70	11	in	in	IN
cord-017420-tjwxec77	70	12	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	70	13	sepsis	sepsis	NN
cord-017420-tjwxec77	70	14	[	[	-LRB-
cord-017420-tjwxec77	70	15	48	48	CD
cord-017420-tjwxec77	70	16	,	,	,
cord-017420-tjwxec77	70	17	49	49	CD
cord-017420-tjwxec77	70	18	]	]	-RRB-
cord-017420-tjwxec77	70	19	,	,	,
cord-017420-tjwxec77	70	20	but	but	CC
cord-017420-tjwxec77	70	21	quantitative	quantitative	JJ
cord-017420-tjwxec77	70	22	cell	cell	NN
cord-017420-tjwxec77	70	23	counts	count	NNS
cord-017420-tjwxec77	70	24	of	of	IN
cord-017420-tjwxec77	70	25	alveolar	alveolar	JJ
cord-017420-tjwxec77	70	26	macrophages	macrophage	NNS
cord-017420-tjwxec77	70	27	,	,	,
cord-017420-tjwxec77	70	28	lymphocytes	lymphocyte	NNS
cord-017420-tjwxec77	70	29	,	,	,
cord-017420-tjwxec77	70	30	and	and	CC
cord-017420-tjwxec77	70	31	neutrophils	neutrophil	NNS
cord-017420-tjwxec77	70	32	are	be	VBP
cord-017420-tjwxec77	70	33	decreased	decrease	VBN
cord-017420-tjwxec77	70	34	during	during	IN
cord-017420-tjwxec77	70	35	neutropenia	neutropenia	NN
cord-017420-tjwxec77	70	36	[	[	-LRB-
cord-017420-tjwxec77	70	37	19	19	CD
cord-017420-tjwxec77	70	38	]	]	-RRB-
cord-017420-tjwxec77	70	39	.	.	.
cord-017420-tjwxec77	71	1	Neutropenia	neutropenia	NN
cord-017420-tjwxec77	71	2	also	also	RB
cord-017420-tjwxec77	71	3	appears	appear	VBZ
cord-017420-tjwxec77	71	4	to	to	TO
cord-017420-tjwxec77	71	5	adversely	adversely	RB
cord-017420-tjwxec77	71	6	affect	affect	VB
cord-017420-tjwxec77	71	7	lung	lung	NN
cord-017420-tjwxec77	71	8	repair	repair	NN
cord-017420-tjwxec77	71	9	after	after	IN
cord-017420-tjwxec77	71	10	injury	injury	NN
cord-017420-tjwxec77	71	11	[	[	-LRB-
cord-017420-tjwxec77	71	12	12	12	CD
cord-017420-tjwxec77	71	13	]	]	-RRB-
cord-017420-tjwxec77	71	14	.	.	.
cord-017420-tjwxec77	72	1	Taken	take	VBN
cord-017420-tjwxec77	72	2	together	together	RB
cord-017420-tjwxec77	72	3	,	,	,
cord-017420-tjwxec77	72	4	these	these	DT
cord-017420-tjwxec77	72	5	data	datum	NNS
cord-017420-tjwxec77	72	6	strongly	strongly	RB
cord-017420-tjwxec77	72	7	support	support	VBP
cord-017420-tjwxec77	72	8	the	the	DT
cord-017420-tjwxec77	72	9	hypothesis	hypothesis	NN
cord-017420-tjwxec77	72	10	that	that	IN
cord-017420-tjwxec77	72	11	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	72	12	sepsis	sepsis	NN
cord-017420-tjwxec77	72	13	has	have	VBZ
cord-017420-tjwxec77	72	14	a	a	DT
cord-017420-tjwxec77	72	15	significantly	significantly	RB
cord-017420-tjwxec77	72	16	different	different	JJ
cord-017420-tjwxec77	72	17	pathophysiology	pathophysiology	NN
cord-017420-tjwxec77	72	18	than	than	IN
cord-017420-tjwxec77	72	19	non	non	JJ
cord-017420-tjwxec77	72	20	-	-	JJ
cord-017420-tjwxec77	72	21	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	72	22	sepsis	sepsis	NN
cord-017420-tjwxec77	72	23	.	.	.
cord-017420-tjwxec77	73	1	As	as	IN
cord-017420-tjwxec77	73	2	defined	define	VBN
cord-017420-tjwxec77	73	3	above	above	RB
cord-017420-tjwxec77	73	4	,	,	,
cord-017420-tjwxec77	73	5	the	the	DT
cord-017420-tjwxec77	73	6	diagnosis	diagnosis	NN
cord-017420-tjwxec77	73	7	of	of	IN
cord-017420-tjwxec77	73	8	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	73	9	fever	fever	NN
cord-017420-tjwxec77	73	10	requires	require	VBZ
cord-017420-tjwxec77	73	11	a	a	DT
cord-017420-tjwxec77	73	12	single	single	JJ
cord-017420-tjwxec77	73	13	temperature	temperature	NN
cord-017420-tjwxec77	73	14	higher	high	JJR
cord-017420-tjwxec77	73	15	than	than	IN
cord-017420-tjwxec77	73	16	38.3	38.3	CD
cord-017420-tjwxec77	73	17	C	c	NN
cord-017420-tjwxec77	73	18	or	or	CC
cord-017420-tjwxec77	73	19	a	a	DT
cord-017420-tjwxec77	73	20	sustained	sustained	JJ
cord-017420-tjwxec77	73	21	temperature	temperature	NN
cord-017420-tjwxec77	73	22	greater	great	JJR
cord-017420-tjwxec77	73	23	than	than	IN
cord-017420-tjwxec77	73	24	38.0	38.0	CD
cord-017420-tjwxec77	73	25	C	c	NN
cord-017420-tjwxec77	73	26	for	for	IN
cord-017420-tjwxec77	73	27	more	more	JJR
cord-017420-tjwxec77	73	28	than	than	IN
cord-017420-tjwxec77	73	29	1	1	CD
cord-017420-tjwxec77	73	30	h	h	NN
cord-017420-tjwxec77	73	31	in	in	IN
cord-017420-tjwxec77	73	32	the	the	DT
cord-017420-tjwxec77	73	33	presence	presence	NN
cord-017420-tjwxec77	73	34	of	of	IN
cord-017420-tjwxec77	73	35	neutropenia	neutropenia	NNP
cord-017420-tjwxec77	73	36	[	[	-LRB-
cord-017420-tjwxec77	73	37	28	28	CD
cord-017420-tjwxec77	73	38	,	,	,
cord-017420-tjwxec77	73	39	33	33	CD
cord-017420-tjwxec77	73	40	]	]	-RRB-
cord-017420-tjwxec77	73	41	.	.	.
cord-017420-tjwxec77	74	1	While	while	IN
cord-017420-tjwxec77	74	2	some	some	DT
cord-017420-tjwxec77	74	3	patients	patient	NNS
cord-017420-tjwxec77	74	4	are	be	VBP
cord-017420-tjwxec77	74	5	asymptomatic	asymptomatic	JJ
cord-017420-tjwxec77	74	6	in	in	IN
cord-017420-tjwxec77	74	7	the	the	DT
cord-017420-tjwxec77	74	8	presence	presence	NN
cord-017420-tjwxec77	74	9	of	of	IN
cord-017420-tjwxec77	74	10	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	74	11	fever	fever	NN
cord-017420-tjwxec77	74	12	,	,	,
cord-017420-tjwxec77	74	13	many	many	JJ
cord-017420-tjwxec77	74	14	describe	describe	VBP
cord-017420-tjwxec77	74	15	non	non	JJ
cord-017420-tjwxec77	74	16	-	-	JJ
cord-017420-tjwxec77	74	17	specific	specific	JJ
cord-017420-tjwxec77	74	18	symptoms	symptom	NNS
cord-017420-tjwxec77	74	19	(	(	-LRB-
cord-017420-tjwxec77	74	20	e.g.	e.g.	RB
cord-017420-tjwxec77	74	21	,	,	,
cord-017420-tjwxec77	74	22	cough	cough	NN
cord-017420-tjwxec77	74	23	,	,	,
cord-017420-tjwxec77	74	24	anorexia	anorexia	NN
cord-017420-tjwxec77	74	25	,	,	,
cord-017420-tjwxec77	74	26	nausea	nausea	NN
cord-017420-tjwxec77	74	27	,	,	,
cord-017420-tjwxec77	74	28	fatigue	fatigue	NN
cord-017420-tjwxec77	74	29	,	,	,
cord-017420-tjwxec77	74	30	dizziness	dizziness	NN
cord-017420-tjwxec77	74	31	,	,	,
cord-017420-tjwxec77	74	32	myalgias	myalgias	NNP
cord-017420-tjwxec77	74	33	,	,	,
cord-017420-tjwxec77	74	34	confusion	confusion	NN
cord-017420-tjwxec77	74	35	,	,	,
cord-017420-tjwxec77	74	36	behavioral	behavioral	JJ
cord-017420-tjwxec77	74	37	changes	change	NNS
cord-017420-tjwxec77	74	38	)	)	-RRB-
cord-017420-tjwxec77	74	39	.	.	.
cord-017420-tjwxec77	75	1	Patients	patient	NNS
cord-017420-tjwxec77	75	2	may	may	MD
cord-017420-tjwxec77	75	3	also	also	RB
cord-017420-tjwxec77	75	4	present	present	VB
cord-017420-tjwxec77	75	5	with	with	IN
cord-017420-tjwxec77	75	6	respiratory	respiratory	JJ
cord-017420-tjwxec77	75	7	symptoms	symptom	NNS
cord-017420-tjwxec77	75	8	(	(	-LRB-
cord-017420-tjwxec77	75	9	cough	cough	NN
cord-017420-tjwxec77	75	10	,	,	,
cord-017420-tjwxec77	75	11	shortness	shortness	NN
cord-017420-tjwxec77	75	12	of	of	IN
cord-017420-tjwxec77	75	13	breath	breath	NN
cord-017420-tjwxec77	75	14	,	,	,
cord-017420-tjwxec77	75	15	sinus	sinus	NN
cord-017420-tjwxec77	75	16	pain	pain	NN
cord-017420-tjwxec77	75	17	or	or	CC
cord-017420-tjwxec77	75	18	drainage	drainage	NN
cord-017420-tjwxec77	75	19	)	)	-RRB-
cord-017420-tjwxec77	75	20	or	or	CC
cord-017420-tjwxec77	75	21	abdominal	abdominal	JJ
cord-017420-tjwxec77	75	22	symptoms	symptom	NNS
cord-017420-tjwxec77	75	23	such	such	JJ
cord-017420-tjwxec77	75	24	as	as	IN
cord-017420-tjwxec77	75	25	pain	pain	NN
cord-017420-tjwxec77	75	26	or	or	CC
cord-017420-tjwxec77	75	27	diarrhea	diarrhea	NN
cord-017420-tjwxec77	75	28	.	.	.
cord-017420-tjwxec77	76	1	Fewer	few	JJR
cord-017420-tjwxec77	76	2	than	than	IN
cord-017420-tjwxec77	76	3	half	half	NN
cord-017420-tjwxec77	76	4	of	of	IN
cord-017420-tjwxec77	76	5	patients	patient	NNS
cord-017420-tjwxec77	76	6	will	will	MD
cord-017420-tjwxec77	76	7	feel	feel	VB
cord-017420-tjwxec77	76	8	feverish	feverish	JJ
cord-017420-tjwxec77	76	9	,	,	,
cord-017420-tjwxec77	76	10	shiver	shiver	NN
cord-017420-tjwxec77	76	11	,	,	,
cord-017420-tjwxec77	76	12	or	or	CC
cord-017420-tjwxec77	76	13	have	have	VBP
cord-017420-tjwxec77	76	14	rigors	rigor	NNS
cord-017420-tjwxec77	76	15	[	[	-LRB-
cord-017420-tjwxec77	76	16	17	17	CD
cord-017420-tjwxec77	76	17	]	]	-RRB-
cord-017420-tjwxec77	76	18	.	.	.
cord-017420-tjwxec77	77	1	Presentation	presentation	NN
cord-017420-tjwxec77	77	2	to	to	IN
cord-017420-tjwxec77	77	3	the	the	DT
cord-017420-tjwxec77	77	4	hospital	hospital	NN
cord-017420-tjwxec77	77	5	can	can	MD
cord-017420-tjwxec77	77	6	be	be	VB
cord-017420-tjwxec77	77	7	delayed	delay	VBN
cord-017420-tjwxec77	77	8	,	,	,
cord-017420-tjwxec77	77	9	with	with	IN
cord-017420-tjwxec77	77	10	one	one	CD
cord-017420-tjwxec77	77	11	study	study	NN
cord-017420-tjwxec77	77	12	suggesting	suggest	VBG
cord-017420-tjwxec77	77	13	a	a	DT
cord-017420-tjwxec77	77	14	mean	mean	JJ
cord-017420-tjwxec77	77	15	delay	delay	NN
cord-017420-tjwxec77	77	16	in	in	IN
cord-017420-tjwxec77	77	17	presentation	presentation	NN
cord-017420-tjwxec77	77	18	of	of	IN
cord-017420-tjwxec77	77	19	11	11	CD
cord-017420-tjwxec77	77	20	h	h	NN
cord-017420-tjwxec77	77	21	and	and	CC
cord-017420-tjwxec77	77	22	nearly	nearly	RB
cord-017420-tjwxec77	77	23	40	40	CD
cord-017420-tjwxec77	77	24	%	%	NN
cord-017420-tjwxec77	77	25	of	of	IN
cord-017420-tjwxec77	77	26	patients	patient	NNS
cord-017420-tjwxec77	77	27	delaying	delay	VBG
cord-017420-tjwxec77	77	28	presentation	presentation	NN
cord-017420-tjwxec77	77	29	for	for	IN
cord-017420-tjwxec77	77	30	more	more	JJR
cord-017420-tjwxec77	77	31	than	than	IN
cord-017420-tjwxec77	77	32	12	12	CD
cord-017420-tjwxec77	77	33	h	h	NN
cord-017420-tjwxec77	77	34	[	[	-LRB-
cord-017420-tjwxec77	77	35	17	17	CD
cord-017420-tjwxec77	77	36	]	]	-RRB-
cord-017420-tjwxec77	77	37	.	.	.
cord-017420-tjwxec77	78	1	Though	though	IN
cord-017420-tjwxec77	78	2	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	78	3	patients	patient	NNS
cord-017420-tjwxec77	78	4	have	have	VBP
cord-017420-tjwxec77	78	5	higher	high	JJR
cord-017420-tjwxec77	78	6	fevers	fever	NNS
cord-017420-tjwxec77	78	7	than	than	IN
cord-017420-tjwxec77	78	8	non	non	JJ
cord-017420-tjwxec77	78	9	-	-	JJ
cord-017420-tjwxec77	78	10	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	78	11	patients	patient	NNS
cord-017420-tjwxec77	78	12	,	,	,
cord-017420-tjwxec77	78	13	there	there	EX
cord-017420-tjwxec77	78	14	is	be	VBZ
cord-017420-tjwxec77	78	15	no	no	DT
cord-017420-tjwxec77	78	16	association	association	NN
cord-017420-tjwxec77	78	17	between	between	IN
cord-017420-tjwxec77	78	18	peak	peak	NN
cord-017420-tjwxec77	78	19	temperature	temperature	NN
cord-017420-tjwxec77	78	20	and	and	CC
cord-017420-tjwxec77	78	21	mortality	mortality	NN
cord-017420-tjwxec77	78	22	.	.	.
cord-017420-tjwxec77	79	1	Hypothermia	hypothermia	NN
cord-017420-tjwxec77	79	2	during	during	IN
cord-017420-tjwxec77	79	3	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	79	4	sepsis	sepsis	NN
cord-017420-tjwxec77	79	5	is	be	VBZ
cord-017420-tjwxec77	79	6	associated	associate	VBN
cord-017420-tjwxec77	79	7	with	with	IN
cord-017420-tjwxec77	79	8	worse	bad	JJR
cord-017420-tjwxec77	79	9	outcomes	outcome	NNS
cord-017420-tjwxec77	79	10	[	[	-LRB-
cord-017420-tjwxec77	79	11	84	84	CD
cord-017420-tjwxec77	79	12	]	]	-RRB-
cord-017420-tjwxec77	79	13	.	.	.
cord-017420-tjwxec77	80	1	Neutropenic	neutropenic	JJ
cord-017420-tjwxec77	80	2	patients	patient	NNS
cord-017420-tjwxec77	80	3	with	with	IN
cord-017420-tjwxec77	80	4	septic	septic	JJ
cord-017420-tjwxec77	80	5	shock	shock	NN
cord-017420-tjwxec77	80	6	tend	tend	VBP
cord-017420-tjwxec77	80	7	to	to	TO
cord-017420-tjwxec77	80	8	have	have	VB
cord-017420-tjwxec77	80	9	more	more	RBR
cord-017420-tjwxec77	80	10	frequently	frequently	RB
cord-017420-tjwxec77	80	11	positive	positive	JJ
cord-017420-tjwxec77	80	12	blood	blood	NN
cord-017420-tjwxec77	80	13	cultures	culture	NNS
cord-017420-tjwxec77	80	14	,	,	,
cord-017420-tjwxec77	80	15	more	more	JJR
cord-017420-tjwxec77	80	16	fungal	fungal	JJ
cord-017420-tjwxec77	80	17	infections	infection	NNS
cord-017420-tjwxec77	80	18	,	,	,
cord-017420-tjwxec77	80	19	more	more	JJR
cord-017420-tjwxec77	80	20	multidrug	multidrug	NN
cord-017420-tjwxec77	80	21	-	-	HYPH
cord-017420-tjwxec77	80	22	resistant	resistant	JJ
cord-017420-tjwxec77	80	23	bacterial	bacterial	JJ
cord-017420-tjwxec77	80	24	infections	infection	NNS
cord-017420-tjwxec77	80	25	,	,	,
cord-017420-tjwxec77	80	26	and	and	CC
cord-017420-tjwxec77	80	27	higher	high	JJR
cord-017420-tjwxec77	80	28	mortality	mortality	NN
cord-017420-tjwxec77	80	29	rates	rate	NNS
cord-017420-tjwxec77	80	30	than	than	IN
cord-017420-tjwxec77	80	31	immunocompetent	immunocompetent	JJ
cord-017420-tjwxec77	80	32	patients	patient	NNS
cord-017420-tjwxec77	80	33	.	.	.
cord-017420-tjwxec77	81	1	Compared	compare	VBN
cord-017420-tjwxec77	81	2	to	to	IN
cord-017420-tjwxec77	81	3	non	non	JJ
cord-017420-tjwxec77	81	4	-	-	JJ
cord-017420-tjwxec77	81	5	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	81	6	patients	patient	NNS
cord-017420-tjwxec77	81	7	,	,	,
cord-017420-tjwxec77	81	8	patients	patient	NNS
cord-017420-tjwxec77	81	9	with	with	IN
cord-017420-tjwxec77	81	10	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	81	11	sepsis	sepsis	NN
cord-017420-tjwxec77	81	12	have	have	VBP
cord-017420-tjwxec77	81	13	higher	high	JJR
cord-017420-tjwxec77	81	14	rates	rate	NNS
cord-017420-tjwxec77	81	15	of	of	IN
cord-017420-tjwxec77	81	16	shock	shock	NN
cord-017420-tjwxec77	81	17	and	and	CC
cord-017420-tjwxec77	81	18	are	be	VBP
cord-017420-tjwxec77	81	19	at	at	IN
cord-017420-tjwxec77	81	20	higher	high	JJR
cord-017420-tjwxec77	81	21	risk	risk	NN
cord-017420-tjwxec77	81	22	to	to	TO
cord-017420-tjwxec77	81	23	sustain	sustain	VB
cord-017420-tjwxec77	81	24	acute	acute	JJ
cord-017420-tjwxec77	81	25	kidney	kidney	NN
cord-017420-tjwxec77	81	26	injury	injury	NN
cord-017420-tjwxec77	81	27	[	[	-LRB-
cord-017420-tjwxec77	81	28	60	60	CD
cord-017420-tjwxec77	81	29	]	]	-RRB-
cord-017420-tjwxec77	81	30	.	.	.
cord-017420-tjwxec77	82	1	Early	early	JJ
cord-017420-tjwxec77	82	2	recognition	recognition	NN
cord-017420-tjwxec77	82	3	of	of	IN
cord-017420-tjwxec77	82	4	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	82	5	fever	fever	NN
cord-017420-tjwxec77	82	6	is	be	VBZ
cord-017420-tjwxec77	82	7	essential	essential	JJ
cord-017420-tjwxec77	82	8	.	.	.
cord-017420-tjwxec77	83	1	Regardless	regardless	RB
cord-017420-tjwxec77	83	2	of	of	IN
cord-017420-tjwxec77	83	3	whether	whether	IN
cord-017420-tjwxec77	83	4	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	83	5	patients	patient	NNS
cord-017420-tjwxec77	83	6	are	be	VBP
cord-017420-tjwxec77	83	7	hospitalized	hospitalize	VBN
cord-017420-tjwxec77	83	8	or	or	CC
cord-017420-tjwxec77	83	9	not	not	RB
cord-017420-tjwxec77	83	10	,	,	,
cord-017420-tjwxec77	83	11	frequent	frequent	JJ
cord-017420-tjwxec77	83	12	temperature	temperature	NN
cord-017420-tjwxec77	83	13	checks	check	NNS
cord-017420-tjwxec77	83	14	are	be	VBP
cord-017420-tjwxec77	83	15	essential	essential	JJ
cord-017420-tjwxec77	83	16	to	to	TO
cord-017420-tjwxec77	83	17	detect	detect	VB
cord-017420-tjwxec77	83	18	fever	fever	NN
cord-017420-tjwxec77	83	19	;	;	:
cord-017420-tjwxec77	83	20	outpatients	outpatient	NNS
cord-017420-tjwxec77	83	21	must	must	MD
cord-017420-tjwxec77	83	22	particularly	particularly	RB
cord-017420-tjwxec77	83	23	be	be	VB
cord-017420-tjwxec77	83	24	educated	educate	VBN
cord-017420-tjwxec77	83	25	on	on	IN
cord-017420-tjwxec77	83	26	the	the	DT
cord-017420-tjwxec77	83	27	importance	importance	NN
cord-017420-tjwxec77	83	28	of	of	IN
cord-017420-tjwxec77	83	29	monitoring	monitor	VBG
cord-017420-tjwxec77	83	30	temperature	temperature	NN
cord-017420-tjwxec77	83	31	.	.	.
cord-017420-tjwxec77	84	1	Similarly	similarly	RB
cord-017420-tjwxec77	84	2	,	,	,
cord-017420-tjwxec77	84	3	interventions	intervention	NNS
cord-017420-tjwxec77	84	4	that	that	WDT
cord-017420-tjwxec77	84	5	might	may	MD
cord-017420-tjwxec77	84	6	mask	mask	VB
cord-017420-tjwxec77	84	7	fevers	fever	NNS
cord-017420-tjwxec77	84	8	(	(	-LRB-
cord-017420-tjwxec77	84	9	e.g.	e.g.	RB
cord-017420-tjwxec77	84	10	,	,	,
cord-017420-tjwxec77	84	11	antipyretics	antipyretic	NNS
cord-017420-tjwxec77	84	12	such	such	JJ
cord-017420-tjwxec77	84	13	as	as	IN
cord-017420-tjwxec77	84	14	acetaminophen	acetaminophen	NN
cord-017420-tjwxec77	84	15	)	)	-RRB-
cord-017420-tjwxec77	84	16	should	should	MD
cord-017420-tjwxec77	84	17	generally	generally	RB
cord-017420-tjwxec77	84	18	be	be	VB
cord-017420-tjwxec77	84	19	avoided	avoid	VBN
cord-017420-tjwxec77	84	20	in	in	IN
cord-017420-tjwxec77	84	21	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	84	22	patients	patient	NNS
cord-017420-tjwxec77	84	23	,	,	,
cord-017420-tjwxec77	84	24	and	and	CC
cord-017420-tjwxec77	84	25	clinicians	clinician	NNS
cord-017420-tjwxec77	84	26	should	should	MD
cord-017420-tjwxec77	84	27	be	be	VB
cord-017420-tjwxec77	84	28	aware	aware	JJ
cord-017420-tjwxec77	84	29	of	of	IN
cord-017420-tjwxec77	84	30	other	other	JJ
cord-017420-tjwxec77	84	31	interventions	intervention	NNS
cord-017420-tjwxec77	84	32	(	(	-LRB-
cord-017420-tjwxec77	84	33	e.g.	e.g.	RB
cord-017420-tjwxec77	84	34	,	,	,
cord-017420-tjwxec77	84	35	steroids	steroid	NNS
cord-017420-tjwxec77	84	36	,	,	,
cord-017420-tjwxec77	84	37	continuous	continuous	JJ
cord-017420-tjwxec77	84	38	renal	renal	JJ
cord-017420-tjwxec77	84	39	replacement	replacement	NN
cord-017420-tjwxec77	84	40	therapy	therapy	NN
cord-017420-tjwxec77	84	41	)	)	-RRB-
cord-017420-tjwxec77	84	42	which	which	WDT
cord-017420-tjwxec77	84	43	may	may	MD
cord-017420-tjwxec77	84	44	suppress	suppress	VB
cord-017420-tjwxec77	84	45	fevers	fever	NNS
cord-017420-tjwxec77	84	46	.	.	.
cord-017420-tjwxec77	85	1	Once	once	RB
cord-017420-tjwxec77	85	2	a	a	DT
cord-017420-tjwxec77	85	3	fever	fever	NN
cord-017420-tjwxec77	85	4	is	be	VBZ
cord-017420-tjwxec77	85	5	detected	detect	VBN
cord-017420-tjwxec77	85	6	,	,	,
cord-017420-tjwxec77	85	7	blood	blood	NN
cord-017420-tjwxec77	85	8	cultures	culture	NNS
cord-017420-tjwxec77	85	9	should	should	MD
cord-017420-tjwxec77	85	10	be	be	VB
cord-017420-tjwxec77	85	11	obtained	obtain	VBN
cord-017420-tjwxec77	85	12	without	without	IN
cord-017420-tjwxec77	85	13	delay	delay	NN
cord-017420-tjwxec77	85	14	,	,	,
cord-017420-tjwxec77	85	15	and	and	CC
cord-017420-tjwxec77	85	16	antibiotics	antibiotic	NNS
cord-017420-tjwxec77	85	17	initiated	initiate	VBD
cord-017420-tjwxec77	85	18	as	as	RB
cord-017420-tjwxec77	85	19	quickly	quickly	RB
cord-017420-tjwxec77	85	20	as	as	IN
cord-017420-tjwxec77	85	21	possible	possible	JJ
cord-017420-tjwxec77	85	22	.	.	.
cord-017420-tjwxec77	86	1	Diagnostic	diagnostic	JJ
cord-017420-tjwxec77	86	2	measures	measure	NNS
cord-017420-tjwxec77	86	3	must	must	MD
cord-017420-tjwxec77	86	4	not	not	RB
cord-017420-tjwxec77	86	5	interfere	interfere	VB
cord-017420-tjwxec77	86	6	with	with	IN
cord-017420-tjwxec77	86	7	the	the	DT
cord-017420-tjwxec77	86	8	timely	timely	JJ
cord-017420-tjwxec77	86	9	administration	administration	NN
cord-017420-tjwxec77	86	10	of	of	IN
cord-017420-tjwxec77	86	11	antibiotics	antibiotic	NNS
cord-017420-tjwxec77	86	12	.	.	.
cord-017420-tjwxec77	87	1	A	a	DT
cord-017420-tjwxec77	87	2	comprehensive	comprehensive	JJ
cord-017420-tjwxec77	87	3	physical	physical	JJ
cord-017420-tjwxec77	87	4	exam	exam	NN
cord-017420-tjwxec77	87	5	should	should	MD
cord-017420-tjwxec77	87	6	be	be	VB
cord-017420-tjwxec77	87	7	performed	perform	VBN
cord-017420-tjwxec77	87	8	and	and	CC
cord-017420-tjwxec77	87	9	may	may	MD
cord-017420-tjwxec77	87	10	uncover	uncover	VB
cord-017420-tjwxec77	87	11	potential	potential	JJ
cord-017420-tjwxec77	87	12	sources	source	NNS
cord-017420-tjwxec77	87	13	of	of	IN
cord-017420-tjwxec77	87	14	infection	infection	NN
cord-017420-tjwxec77	87	15	(	(	-LRB-
cord-017420-tjwxec77	87	16	e.g.	e.g.	RB
cord-017420-tjwxec77	87	17	,	,	,
cord-017420-tjwxec77	87	18	mouth	mouth	NN
cord-017420-tjwxec77	87	19	sores	sore	NNS
cord-017420-tjwxec77	87	20	,	,	,
cord-017420-tjwxec77	87	21	skin	skin	NN
cord-017420-tjwxec77	87	22	lesions	lesion	NNS
cord-017420-tjwxec77	87	23	,	,	,
cord-017420-tjwxec77	87	24	pulmonary	pulmonary	JJ
cord-017420-tjwxec77	87	25	findings	finding	NNS
cord-017420-tjwxec77	87	26	,	,	,
cord-017420-tjwxec77	87	27	abdominal	abdominal	JJ
cord-017420-tjwxec77	87	28	tenderness	tenderness	NN
cord-017420-tjwxec77	87	29	or	or	CC
cord-017420-tjwxec77	87	30	pain	pain	NN
cord-017420-tjwxec77	87	31	)	)	-RRB-
cord-017420-tjwxec77	87	32	.	.	.
cord-017420-tjwxec77	88	1	Blood	blood	NN
cord-017420-tjwxec77	88	2	cultures	culture	NNS
cord-017420-tjwxec77	88	3	are	be	VBP
cord-017420-tjwxec77	88	4	essential	essential	JJ
cord-017420-tjwxec77	88	5	to	to	IN
cord-017420-tjwxec77	88	6	the	the	DT
cord-017420-tjwxec77	88	7	evaluation	evaluation	NN
cord-017420-tjwxec77	88	8	of	of	IN
cord-017420-tjwxec77	88	9	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	88	10	patients	patient	NNS
cord-017420-tjwxec77	88	11	with	with	IN
cord-017420-tjwxec77	88	12	fever	fever	NN
cord-017420-tjwxec77	88	13	.	.	.
cord-017420-tjwxec77	89	1	A	a	DT
cord-017420-tjwxec77	89	2	minimum	minimum	NN
cord-017420-tjwxec77	89	3	of	of	IN
cord-017420-tjwxec77	89	4	two	two	CD
cord-017420-tjwxec77	89	5	sets	set	NNS
cord-017420-tjwxec77	89	6	of	of	IN
cord-017420-tjwxec77	89	7	blood	blood	NN
cord-017420-tjwxec77	89	8	cultures	culture	NNS
cord-017420-tjwxec77	89	9	should	should	MD
cord-017420-tjwxec77	89	10	be	be	VB
cord-017420-tjwxec77	89	11	drawn	draw	VBN
cord-017420-tjwxec77	89	12	upon	upon	IN
cord-017420-tjwxec77	89	13	presentation	presentation	NN
cord-017420-tjwxec77	89	14	.	.	.
cord-017420-tjwxec77	90	1	Current	current	JJ
cord-017420-tjwxec77	90	2	recommendations	recommendation	NNS
cord-017420-tjwxec77	90	3	suggest	suggest	VBP
cord-017420-tjwxec77	90	4	obtaining	obtain	VBG
cord-017420-tjwxec77	90	5	two	two	CD
cord-017420-tjwxec77	90	6	sets	set	NNS
cord-017420-tjwxec77	90	7	of	of	IN
cord-017420-tjwxec77	90	8	cultures	culture	NNS
cord-017420-tjwxec77	90	9	,	,	,
cord-017420-tjwxec77	90	10	including	include	VBG
cord-017420-tjwxec77	90	11	both	both	DT
cord-017420-tjwxec77	90	12	peripheral	peripheral	JJ
cord-017420-tjwxec77	90	13	blood	blood	NN
cord-017420-tjwxec77	90	14	cultures	culture	NNS
cord-017420-tjwxec77	90	15	and	and	CC
cord-017420-tjwxec77	90	16	cultures	culture	NNS
cord-017420-tjwxec77	90	17	from	from	IN
cord-017420-tjwxec77	90	18	a	a	DT
cord-017420-tjwxec77	90	19	central	central	JJ
cord-017420-tjwxec77	90	20	venous	venous	JJ
cord-017420-tjwxec77	90	21	catheter	catheter	NN
cord-017420-tjwxec77	90	22	,	,	,
cord-017420-tjwxec77	90	23	if	if	IN
cord-017420-tjwxec77	90	24	present	present	JJ
cord-017420-tjwxec77	90	25	[	[	-LRB-
cord-017420-tjwxec77	90	26	28	28	CD
cord-017420-tjwxec77	90	27	,	,	,
cord-017420-tjwxec77	90	28	33	33	CD
cord-017420-tjwxec77	90	29	]	]	-RRB-
cord-017420-tjwxec77	90	30	.	.	.
cord-017420-tjwxec77	91	1	Additional	additional	JJ
cord-017420-tjwxec77	91	2	laboratory	laboratory	NN
cord-017420-tjwxec77	91	3	studies	study	NNS
cord-017420-tjwxec77	91	4	at	at	IN
cord-017420-tjwxec77	91	5	presentation	presentation	NN
cord-017420-tjwxec77	91	6	should	should	MD
cord-017420-tjwxec77	91	7	include	include	VB
cord-017420-tjwxec77	91	8	complete	complete	JJ
cord-017420-tjwxec77	91	9	blood	blood	NN
cord-017420-tjwxec77	91	10	count	count	NN
cord-017420-tjwxec77	91	11	with	with	IN
cord-017420-tjwxec77	91	12	differential	differential	NN
cord-017420-tjwxec77	91	13	,	,	,
cord-017420-tjwxec77	91	14	electrolytes	electrolyte	NNS
cord-017420-tjwxec77	91	15	,	,	,
cord-017420-tjwxec77	91	16	and	and	CC
cord-017420-tjwxec77	91	17	markers	marker	NNS
cord-017420-tjwxec77	91	18	of	of	IN
cord-017420-tjwxec77	91	19	renal	renal	JJ
cord-017420-tjwxec77	91	20	and	and	CC
cord-017420-tjwxec77	91	21	hepatic	hepatic	JJ
cord-017420-tjwxec77	91	22	function	function	NN
cord-017420-tjwxec77	91	23	(	(	-LRB-
cord-017420-tjwxec77	91	24	creatinine	creatinine	NN
cord-017420-tjwxec77	91	25	,	,	,
cord-017420-tjwxec77	91	26	blood	blood	NN
cord-017420-tjwxec77	91	27	urea	urea	NN
cord-017420-tjwxec77	91	28	nitrogen	nitrogen	NN
cord-017420-tjwxec77	91	29	,	,	,
cord-017420-tjwxec77	91	30	transaminases	transaminase	NNS
cord-017420-tjwxec77	91	31	)	)	-RRB-
cord-017420-tjwxec77	91	32	.	.	.
cord-017420-tjwxec77	92	1	Depending	depend	VBG
cord-017420-tjwxec77	92	2	on	on	IN
cord-017420-tjwxec77	92	3	the	the	DT
cord-017420-tjwxec77	92	4	clinical	clinical	JJ
cord-017420-tjwxec77	92	5	scenario	scenario	NN
cord-017420-tjwxec77	92	6	,	,	,
cord-017420-tjwxec77	92	7	strong	strong	JJ
cord-017420-tjwxec77	92	8	consideration	consideration	NN
cord-017420-tjwxec77	92	9	should	should	MD
cord-017420-tjwxec77	92	10	be	be	VB
cord-017420-tjwxec77	92	11	given	give	VBN
cord-017420-tjwxec77	92	12	to	to	IN
cord-017420-tjwxec77	92	13	obtaining	obtain	VBG
cord-017420-tjwxec77	92	14	an	an	DT
cord-017420-tjwxec77	92	15	arterial	arterial	JJ
cord-017420-tjwxec77	92	16	blood	blood	NN
cord-017420-tjwxec77	92	17	gas	gas	NN
cord-017420-tjwxec77	92	18	,	,	,
cord-017420-tjwxec77	92	19	coagulation	coagulation	NN
cord-017420-tjwxec77	92	20	studies	study	NNS
cord-017420-tjwxec77	92	21	,	,	,
cord-017420-tjwxec77	92	22	and	and	CC
cord-017420-tjwxec77	92	23	lactate	lactate	NN
cord-017420-tjwxec77	92	24	level	level	NN
cord-017420-tjwxec77	92	25	[	[	-LRB-
cord-017420-tjwxec77	92	26	33	33	CD
cord-017420-tjwxec77	92	27	]	]	-RRB-
cord-017420-tjwxec77	92	28	.	.	.
cord-017420-tjwxec77	93	1	Lactate	lactate	NN
cord-017420-tjwxec77	93	2	is	be	VBZ
cord-017420-tjwxec77	93	3	of	of	IN
cord-017420-tjwxec77	93	4	particular	particular	JJ
cord-017420-tjwxec77	93	5	potential	potential	JJ
cord-017420-tjwxec77	93	6	interest	interest	NN
cord-017420-tjwxec77	93	7	,	,	,
cord-017420-tjwxec77	93	8	as	as	IN
cord-017420-tjwxec77	93	9	an	an	DT
cord-017420-tjwxec77	93	10	elevated	elevated	JJ
cord-017420-tjwxec77	93	11	level	level	NN
cord-017420-tjwxec77	93	12	may	may	MD
cord-017420-tjwxec77	93	13	help	help	VB
cord-017420-tjwxec77	93	14	detect	detect	VB
cord-017420-tjwxec77	93	15	early	early	JJ
cord-017420-tjwxec77	93	16	evidence	evidence	NN
cord-017420-tjwxec77	93	17	of	of	IN
cord-017420-tjwxec77	93	18	sepsis	sepsis	NN
cord-017420-tjwxec77	93	19	-	-	HYPH
cord-017420-tjwxec77	93	20	induced	induce	VBN
cord-017420-tjwxec77	93	21	malperfusion	malperfusion	NN
cord-017420-tjwxec77	93	22	[	[	-LRB-
cord-017420-tjwxec77	93	23	33	33	CD
cord-017420-tjwxec77	93	24	,	,	,
cord-017420-tjwxec77	93	25	70	70	CD
cord-017420-tjwxec77	93	26	]	]	-RRB-
cord-017420-tjwxec77	93	27	.	.	.
cord-017420-tjwxec77	94	1	Other	other	JJ
cord-017420-tjwxec77	94	2	microbiologic	microbiologic	JJ
cord-017420-tjwxec77	94	3	studies	study	NNS
cord-017420-tjwxec77	94	4	can	can	MD
cord-017420-tjwxec77	94	5	be	be	VB
cord-017420-tjwxec77	94	6	targeted	target	VBN
cord-017420-tjwxec77	94	7	toward	toward	IN
cord-017420-tjwxec77	94	8	patient	patient	NN
cord-017420-tjwxec77	94	9	-	-	HYPH
cord-017420-tjwxec77	94	10	specific	specific	JJ
cord-017420-tjwxec77	94	11	indicators	indicator	NNS
cord-017420-tjwxec77	94	12	.	.	.
cord-017420-tjwxec77	95	1	For	for	IN
cord-017420-tjwxec77	95	2	example	example	NN
cord-017420-tjwxec77	95	3	,	,	,
cord-017420-tjwxec77	95	4	urinary	urinary	JJ
cord-017420-tjwxec77	95	5	symptoms	symptom	NNS
cord-017420-tjwxec77	95	6	or	or	CC
cord-017420-tjwxec77	95	7	an	an	DT
cord-017420-tjwxec77	95	8	abnormal	abnormal	JJ
cord-017420-tjwxec77	95	9	urinalysis	urinalysis	NN
cord-017420-tjwxec77	95	10	should	should	MD
cord-017420-tjwxec77	95	11	prompt	prompt	VB
cord-017420-tjwxec77	95	12	urine	urine	NN
cord-017420-tjwxec77	95	13	cultures	culture	NNS
cord-017420-tjwxec77	95	14	.	.	.
cord-017420-tjwxec77	96	1	Diarrhea	diarrhea	NN
cord-017420-tjwxec77	96	2	,	,	,
cord-017420-tjwxec77	96	3	especially	especially	RB
cord-017420-tjwxec77	96	4	in	in	IN
cord-017420-tjwxec77	96	5	a	a	DT
cord-017420-tjwxec77	96	6	patient	patient	NN
cord-017420-tjwxec77	96	7	treated	treat	VBN
cord-017420-tjwxec77	96	8	with	with	IN
cord-017420-tjwxec77	96	9	antibiotics	antibiotic	NNS
cord-017420-tjwxec77	96	10	,	,	,
cord-017420-tjwxec77	96	11	should	should	MD
cord-017420-tjwxec77	96	12	prompt	prompt	VB
cord-017420-tjwxec77	96	13	evaluation	evaluation	NN
cord-017420-tjwxec77	96	14	for	for	IN
cord-017420-tjwxec77	96	15	Clostridium	clostridium	NN
cord-017420-tjwxec77	96	16	difficile	difficile	NN
cord-017420-tjwxec77	96	17	colitis	colitis	NN
cord-017420-tjwxec77	96	18	.	.	.
cord-017420-tjwxec77	97	1	Fungal	fungal	JJ
cord-017420-tjwxec77	97	2	markers	marker	NNS
cord-017420-tjwxec77	97	3	such	such	JJ
cord-017420-tjwxec77	97	4	as	as	IN
cord-017420-tjwxec77	97	5	galactomannan	galactomannan	NNP
cord-017420-tjwxec77	97	6	or	or	CC
cord-017420-tjwxec77	97	7	beta	beta	NN
cord-017420-tjwxec77	97	8	-	-	HYPH
cord-017420-tjwxec77	97	9	D	d	NN
cord-017420-tjwxec77	97	10	-	-	HYPH
cord-017420-tjwxec77	97	11	glucan	glucan	NN
cord-017420-tjwxec77	97	12	may	may	MD
cord-017420-tjwxec77	97	13	be	be	VB
cord-017420-tjwxec77	97	14	useful	useful	JJ
cord-017420-tjwxec77	97	15	in	in	IN
cord-017420-tjwxec77	97	16	some	some	DT
cord-017420-tjwxec77	97	17	patients	patient	NNS
cord-017420-tjwxec77	97	18	[	[	-LRB-
cord-017420-tjwxec77	97	19	33	33	CD
cord-017420-tjwxec77	97	20	]	]	-RRB-
cord-017420-tjwxec77	97	21	.	.	.
cord-017420-tjwxec77	98	1	Respiratory	respiratory	JJ
cord-017420-tjwxec77	98	2	symptoms	symptom	NNS
cord-017420-tjwxec77	98	3	or	or	CC
cord-017420-tjwxec77	98	4	abnormalities	abnormality	NNS
cord-017420-tjwxec77	98	5	on	on	IN
cord-017420-tjwxec77	98	6	chest	chest	NN
cord-017420-tjwxec77	98	7	imaging	imaging	NN
cord-017420-tjwxec77	98	8	should	should	MD
cord-017420-tjwxec77	98	9	be	be	VB
cord-017420-tjwxec77	98	10	evaluated	evaluate	VBN
cord-017420-tjwxec77	98	11	with	with	IN
cord-017420-tjwxec77	98	12	testing	testing	NN
cord-017420-tjwxec77	98	13	for	for	IN
cord-017420-tjwxec77	98	14	respiratory	respiratory	JJ
cord-017420-tjwxec77	98	15	viruses	virus	NNS
cord-017420-tjwxec77	98	16	and	and	CC
cord-017420-tjwxec77	98	17	sputum	sputum	NN
cord-017420-tjwxec77	98	18	culture	culture	NN
cord-017420-tjwxec77	98	19	[	[	-LRB-
cord-017420-tjwxec77	98	20	28	28	CD
cord-017420-tjwxec77	98	21	]	]	-RRB-
cord-017420-tjwxec77	98	22	.	.	.
cord-017420-tjwxec77	99	1	Symptom	symptom	NN
cord-017420-tjwxec77	99	2	-	-	HYPH
cord-017420-tjwxec77	99	3	guided	guide	VBN
cord-017420-tjwxec77	99	4	imaging	imaging	NN
cord-017420-tjwxec77	99	5	studies	study	NNS
cord-017420-tjwxec77	99	6	comprise	comprise	VBP
cord-017420-tjwxec77	99	7	an	an	DT
cord-017420-tjwxec77	99	8	important	important	JJ
cord-017420-tjwxec77	99	9	part	part	NN
cord-017420-tjwxec77	99	10	of	of	IN
cord-017420-tjwxec77	99	11	the	the	DT
cord-017420-tjwxec77	99	12	evaluation	evaluation	NN
cord-017420-tjwxec77	99	13	of	of	IN
cord-017420-tjwxec77	99	14	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	99	15	fever	fever	NN
cord-017420-tjwxec77	99	16	.	.	.
cord-017420-tjwxec77	100	1	Chest	chest	NN
cord-017420-tjwxec77	100	2	computed	compute	VBN
cord-017420-tjwxec77	100	3	tomography	tomography	NN
cord-017420-tjwxec77	100	4	(	(	-LRB-
cord-017420-tjwxec77	100	5	CT	CT	NNP
cord-017420-tjwxec77	100	6	)	)	-RRB-
cord-017420-tjwxec77	100	7	scanning	scanning	NN
cord-017420-tjwxec77	100	8	should	should	MD
cord-017420-tjwxec77	100	9	be	be	VB
cord-017420-tjwxec77	100	10	performed	perform	VBN
cord-017420-tjwxec77	100	11	in	in	IN
cord-017420-tjwxec77	100	12	patients	patient	NNS
cord-017420-tjwxec77	100	13	with	with	IN
cord-017420-tjwxec77	100	14	respiratory	respiratory	JJ
cord-017420-tjwxec77	100	15	symptoms	symptom	NNS
cord-017420-tjwxec77	100	16	,	,	,
cord-017420-tjwxec77	100	17	and	and	CC
cord-017420-tjwxec77	100	18	potentially	potentially	RB
cord-017420-tjwxec77	100	19	asymptomatic	asymptomatic	JJ
cord-017420-tjwxec77	100	20	patients	patient	NNS
cord-017420-tjwxec77	100	21	with	with	IN
cord-017420-tjwxec77	100	22	cryptic	cryptic	JJ
cord-017420-tjwxec77	100	23	fevers	fever	NNS
cord-017420-tjwxec77	100	24	[	[	-LRB-
cord-017420-tjwxec77	100	25	33	33	CD
cord-017420-tjwxec77	100	26	]	]	-RRB-
cord-017420-tjwxec77	100	27	.	.	.
cord-017420-tjwxec77	101	1	Plain	plain	JJ
cord-017420-tjwxec77	101	2	chest	chest	NN
cord-017420-tjwxec77	101	3	radiographs	radiograph	NNS
cord-017420-tjwxec77	101	4	are	be	VBP
cord-017420-tjwxec77	101	5	of	of	IN
cord-017420-tjwxec77	101	6	limited	limited	JJ
cord-017420-tjwxec77	101	7	utility	utility	NN
cord-017420-tjwxec77	101	8	in	in	IN
cord-017420-tjwxec77	101	9	this	this	DT
cord-017420-tjwxec77	101	10	population	population	NN
cord-017420-tjwxec77	101	11	and	and	CC
cord-017420-tjwxec77	101	12	should	should	MD
cord-017420-tjwxec77	101	13	not	not	RB
cord-017420-tjwxec77	101	14	be	be	VB
cord-017420-tjwxec77	101	15	routinely	routinely	RB
cord-017420-tjwxec77	101	16	obtained	obtain	VBN
cord-017420-tjwxec77	101	17	in	in	IN
cord-017420-tjwxec77	101	18	lieu	lieu	NN
cord-017420-tjwxec77	101	19	of	of	IN
cord-017420-tjwxec77	101	20	CT	CT	NNP
cord-017420-tjwxec77	101	21	scans	scan	NNS
cord-017420-tjwxec77	101	22	[	[	-LRB-
cord-017420-tjwxec77	101	23	87	87	CD
cord-017420-tjwxec77	101	24	]	]	-RRB-
cord-017420-tjwxec77	101	25	.	.	.
cord-017420-tjwxec77	102	1	Sinus	Sinus	NNP
cord-017420-tjwxec77	102	2	,	,	,
cord-017420-tjwxec77	102	3	head	head	NN
cord-017420-tjwxec77	102	4	,	,	,
cord-017420-tjwxec77	102	5	and	and	CC
cord-017420-tjwxec77	102	6	abdominal	abdominal	JJ
cord-017420-tjwxec77	102	7	imaging	imaging	NN
cord-017420-tjwxec77	102	8	should	should	MD
cord-017420-tjwxec77	102	9	be	be	VB
cord-017420-tjwxec77	102	10	performed	perform	VBN
cord-017420-tjwxec77	102	11	as	as	IN
cord-017420-tjwxec77	102	12	indicated	indicate	VBN
cord-017420-tjwxec77	102	13	[	[	-LRB-
cord-017420-tjwxec77	102	14	28	28	CD
cord-017420-tjwxec77	102	15	,	,	,
cord-017420-tjwxec77	102	16	33	33	CD
cord-017420-tjwxec77	102	17	]	]	-RRB-
cord-017420-tjwxec77	102	18	.	.	.
cord-017420-tjwxec77	103	1	The	the	DT
cord-017420-tjwxec77	103	2	use	use	NN
cord-017420-tjwxec77	103	3	of	of	IN
cord-017420-tjwxec77	103	4	nuclear	nuclear	JJ
cord-017420-tjwxec77	103	5	medicine	medicine	NN
cord-017420-tjwxec77	103	6	techniques	technique	NNS
cord-017420-tjwxec77	103	7	such	such	JJ
cord-017420-tjwxec77	103	8	as	as	IN
cord-017420-tjwxec77	103	9	FDG	FDG	NNP
cord-017420-tjwxec77	103	10	-	-	HYPH
cord-017420-tjwxec77	103	11	PET/	PET/	NNP
cord-017420-tjwxec77	103	12	CT	CT	NNP
cord-017420-tjwxec77	103	13	to	to	TO
cord-017420-tjwxec77	103	14	identify	identify	VB
cord-017420-tjwxec77	103	15	foci	foci	NN
cord-017420-tjwxec77	103	16	of	of	IN
cord-017420-tjwxec77	103	17	infections	infection	NNS
cord-017420-tjwxec77	103	18	in	in	IN
cord-017420-tjwxec77	103	19	febrile	febrile	JJ
cord-017420-tjwxec77	103	20	neutropenia	neutropenia	NN
cord-017420-tjwxec77	103	21	has	have	VBZ
cord-017420-tjwxec77	103	22	been	be	VBN
cord-017420-tjwxec77	103	23	described	describe	VBN
cord-017420-tjwxec77	103	24	,	,	,
cord-017420-tjwxec77	103	25	but	but	CC
cord-017420-tjwxec77	103	26	the	the	DT
cord-017420-tjwxec77	103	27	utility	utility	NN
cord-017420-tjwxec77	103	28	of	of	IN
cord-017420-tjwxec77	103	29	these	these	DT
cord-017420-tjwxec77	103	30	techniques	technique	NNS
cord-017420-tjwxec77	103	31	has	have	VBZ
cord-017420-tjwxec77	103	32	not	not	RB
cord-017420-tjwxec77	103	33	yet	yet	RB
cord-017420-tjwxec77	103	34	been	be	VBN
cord-017420-tjwxec77	103	35	proven	prove	VBN
cord-017420-tjwxec77	103	36	,	,	,
cord-017420-tjwxec77	103	37	and	and	CC
cord-017420-tjwxec77	103	38	remains	remain	VBZ
cord-017420-tjwxec77	103	39	impractical	impractical	JJ
cord-017420-tjwxec77	103	40	for	for	IN
cord-017420-tjwxec77	103	41	current	current	JJ
cord-017420-tjwxec77	103	42	clinical	clinical	JJ
cord-017420-tjwxec77	103	43	use	use	NN
cord-017420-tjwxec77	103	44	[	[	-LRB-
cord-017420-tjwxec77	103	45	80	80	CD
cord-017420-tjwxec77	103	46	]	]	-RRB-
cord-017420-tjwxec77	103	47	.	.	.
cord-017420-tjwxec77	104	1	As	as	IN
cord-017420-tjwxec77	104	2	noted	note	VBN
cord-017420-tjwxec77	104	3	above	above	RB
cord-017420-tjwxec77	104	4	,	,	,
cord-017420-tjwxec77	104	5	respiratory	respiratory	JJ
cord-017420-tjwxec77	104	6	symptoms	symptom	NNS
cord-017420-tjwxec77	104	7	and/or	and/or	CC
cord-017420-tjwxec77	104	8	the	the	DT
cord-017420-tjwxec77	104	9	presence	presence	NN
cord-017420-tjwxec77	104	10	of	of	IN
cord-017420-tjwxec77	104	11	abnormalities	abnormality	NNS
cord-017420-tjwxec77	104	12	on	on	IN
cord-017420-tjwxec77	104	13	chest	chest	NN
cord-017420-tjwxec77	104	14	imaging	imaging	NN
cord-017420-tjwxec77	104	15	should	should	MD
cord-017420-tjwxec77	104	16	prompt	prompt	VB
cord-017420-tjwxec77	104	17	evaluation	evaluation	NN
cord-017420-tjwxec77	104	18	for	for	IN
cord-017420-tjwxec77	104	19	a	a	DT
cord-017420-tjwxec77	104	20	respiratory	respiratory	JJ
cord-017420-tjwxec77	104	21	infection	infection	NN
cord-017420-tjwxec77	104	22	.	.	.
cord-017420-tjwxec77	105	1	In	in	IN
cord-017420-tjwxec77	105	2	most	most	JJS
cord-017420-tjwxec77	105	3	cases	case	NNS
cord-017420-tjwxec77	105	4	,	,	,
cord-017420-tjwxec77	105	5	this	this	DT
cord-017420-tjwxec77	105	6	can	can	MD
cord-017420-tjwxec77	105	7	be	be	VB
cord-017420-tjwxec77	105	8	done	do	VBN
cord-017420-tjwxec77	105	9	noninvasively	noninvasively	RB
cord-017420-tjwxec77	105	10	[	[	-LRB-
cord-017420-tjwxec77	105	11	6	6	CD
cord-017420-tjwxec77	105	12	,	,	,
cord-017420-tjwxec77	105	13	8	8	CD
cord-017420-tjwxec77	105	14	,	,	,
cord-017420-tjwxec77	105	15	10	10	CD
cord-017420-tjwxec77	105	16	]	]	-RRB-
cord-017420-tjwxec77	105	17	.	.	.
cord-017420-tjwxec77	106	1	Bronchoscopy	Bronchoscopy	NNP
cord-017420-tjwxec77	106	2	may	may	MD
cord-017420-tjwxec77	106	3	be	be	VB
cord-017420-tjwxec77	106	4	indicated	indicate	VBN
cord-017420-tjwxec77	106	5	in	in	IN
cord-017420-tjwxec77	106	6	some	some	DT
cord-017420-tjwxec77	106	7	patients	patient	NNS
cord-017420-tjwxec77	106	8	,	,	,
cord-017420-tjwxec77	106	9	but	but	CC
cord-017420-tjwxec77	106	10	the	the	DT
cord-017420-tjwxec77	106	11	benefits	benefit	NNS
cord-017420-tjwxec77	106	12	of	of	IN
cord-017420-tjwxec77	106	13	potential	potential	JJ
cord-017420-tjwxec77	106	14	diagnosis	diagnosis	NN
cord-017420-tjwxec77	106	15	must	must	MD
cord-017420-tjwxec77	106	16	be	be	VB
cord-017420-tjwxec77	106	17	weighed	weigh	VBN
cord-017420-tjwxec77	106	18	against	against	IN
cord-017420-tjwxec77	106	19	the	the	DT
cord-017420-tjwxec77	106	20	risk	risk	NN
cord-017420-tjwxec77	106	21	of	of	IN
cord-017420-tjwxec77	106	22	requiring	require	VBG
cord-017420-tjwxec77	106	23	endotracheal	endotracheal	NN
cord-017420-tjwxec77	106	24	intubation	intubation	NN
cord-017420-tjwxec77	106	25	during	during	IN
cord-017420-tjwxec77	106	26	bronchoscopy	bronchoscopy	NN
cord-017420-tjwxec77	106	27	.	.	.
cord-017420-tjwxec77	107	1	Abdominal	abdominal	JJ
cord-017420-tjwxec77	107	2	symptoms	symptom	NNS
cord-017420-tjwxec77	107	3	(	(	-LRB-
cord-017420-tjwxec77	107	4	pain	pain	NN
cord-017420-tjwxec77	107	5	,	,	,
cord-017420-tjwxec77	107	6	diarrhea	diarrhea	NN
cord-017420-tjwxec77	107	7	)	)	-RRB-
cord-017420-tjwxec77	107	8	should	should	MD
cord-017420-tjwxec77	107	9	lead	lead	VB
cord-017420-tjwxec77	107	10	to	to	IN
cord-017420-tjwxec77	107	11	consideration	consideration	NN
cord-017420-tjwxec77	107	12	of	of	IN
cord-017420-tjwxec77	107	13	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	107	14	enterocolitis	enterocolitis	NN
cord-017420-tjwxec77	107	15	,	,	,
cord-017420-tjwxec77	107	16	also	also	RB
cord-017420-tjwxec77	107	17	known	know	VBN
cord-017420-tjwxec77	107	18	as	as	IN
cord-017420-tjwxec77	107	19	typhlitis	typhlitis	NNP
cord-017420-tjwxec77	107	20	,	,	,
cord-017420-tjwxec77	107	21	which	which	WDT
cord-017420-tjwxec77	107	22	is	be	VBZ
cord-017420-tjwxec77	107	23	an	an	DT
cord-017420-tjwxec77	107	24	incompletely	incompletely	RB
cord-017420-tjwxec77	107	25	understood	understand	VBN
cord-017420-tjwxec77	107	26	condition	condition	NN
cord-017420-tjwxec77	107	27	of	of	IN
cord-017420-tjwxec77	107	28	ileocolonic	ileocolonic	JJ
cord-017420-tjwxec77	107	29	inflammation	inflammation	NN
cord-017420-tjwxec77	107	30	which	which	WDT
cord-017420-tjwxec77	107	31	can	can	MD
cord-017420-tjwxec77	107	32	lead	lead	VB
cord-017420-tjwxec77	107	33	to	to	IN
cord-017420-tjwxec77	107	34	intestinal	intestinal	JJ
cord-017420-tjwxec77	107	35	necrosis	necrosis	NN
cord-017420-tjwxec77	107	36	and	and	CC
cord-017420-tjwxec77	107	37	perforation	perforation	NN
cord-017420-tjwxec77	107	38	and	and	CC
cord-017420-tjwxec77	107	39	is	be	VBZ
cord-017420-tjwxec77	107	40	associated	associate	VBN
cord-017420-tjwxec77	107	41	with	with	IN
cord-017420-tjwxec77	107	42	a	a	DT
cord-017420-tjwxec77	107	43	high	high	JJ
cord-017420-tjwxec77	107	44	mortality	mortality	NN
cord-017420-tjwxec77	107	45	rate	rate	NN
cord-017420-tjwxec77	107	46	[	[	-LRB-
cord-017420-tjwxec77	107	47	63	63	CD
cord-017420-tjwxec77	107	48	,	,	,
cord-017420-tjwxec77	107	49	64	64	CD
cord-017420-tjwxec77	107	50	]	]	-RRB-
cord-017420-tjwxec77	107	51	.	.	.
cord-017420-tjwxec77	108	1	Diagnosis	diagnosis	NN
cord-017420-tjwxec77	108	2	requires	require	VBZ
cord-017420-tjwxec77	108	3	the	the	DT
cord-017420-tjwxec77	108	4	presence	presence	NN
cord-017420-tjwxec77	108	5	of	of	IN
cord-017420-tjwxec77	108	6	neutropenia	neutropenia	NN
cord-017420-tjwxec77	108	7	,	,	,
cord-017420-tjwxec77	108	8	bowel	bowel	NN
cord-017420-tjwxec77	108	9	wall	wall	NN
cord-017420-tjwxec77	108	10	thickening	thicken	VBG
cord-017420-tjwxec77	108	11	>	>	XX
cord-017420-tjwxec77	108	12	4	4	CD
cord-017420-tjwxec77	108	13	mm	mm	NNS
cord-017420-tjwxec77	108	14	over	over	IN
cord-017420-tjwxec77	108	15	a	a	DT
cord-017420-tjwxec77	108	16	>	>	SYM
cord-017420-tjwxec77	108	17	30	30	CD
cord-017420-tjwxec77	108	18	mm	mm	NN
cord-017420-tjwxec77	108	19	longitudinal	longitudinal	JJ
cord-017420-tjwxec77	108	20	distance	distance	NN
cord-017420-tjwxec77	108	21	,	,	,
cord-017420-tjwxec77	108	22	fever	fever	NN
cord-017420-tjwxec77	108	23	>	>	XX
cord-017420-tjwxec77	108	24	38	38	CD
cord-017420-tjwxec77	108	25	C	c	NN
cord-017420-tjwxec77	108	26	,	,	,
cord-017420-tjwxec77	108	27	and	and	CC
cord-017420-tjwxec77	108	28	abdominal	abdominal	JJ
cord-017420-tjwxec77	108	29	pain	pain	NN
cord-017420-tjwxec77	108	30	[	[	-LRB-
cord-017420-tjwxec77	108	31	31	31	CD
cord-017420-tjwxec77	108	32	,	,	,
cord-017420-tjwxec77	108	33	51	51	CD
cord-017420-tjwxec77	108	34	,	,	,
cord-017420-tjwxec77	108	35	63	63	CD
cord-017420-tjwxec77	108	36	]	]	-RRB-
cord-017420-tjwxec77	108	37	.	.	.
cord-017420-tjwxec77	109	1	Specific	specific	JJ
cord-017420-tjwxec77	109	2	diagnosis	diagnosis	NN
cord-017420-tjwxec77	109	3	is	be	VBZ
cord-017420-tjwxec77	109	4	elusive	elusive	JJ
cord-017420-tjwxec77	109	5	in	in	IN
cord-017420-tjwxec77	109	6	many	many	JJ
cord-017420-tjwxec77	109	7	patients	patient	NNS
cord-017420-tjwxec77	109	8	,	,	,
cord-017420-tjwxec77	109	9	and	and	CC
cord-017420-tjwxec77	109	10	diagnostic	diagnostic	JJ
cord-017420-tjwxec77	109	11	steps	step	NNS
cord-017420-tjwxec77	109	12	should	should	MD
cord-017420-tjwxec77	109	13	be	be	VB
cord-017420-tjwxec77	109	14	repeated	repeat	VBN
cord-017420-tjwxec77	109	15	if	if	IN
cord-017420-tjwxec77	109	16	no	no	DT
cord-017420-tjwxec77	109	17	source	source	NN
cord-017420-tjwxec77	109	18	is	be	VBZ
cord-017420-tjwxec77	109	19	found	find	VBN
cord-017420-tjwxec77	109	20	and	and	CC
cord-017420-tjwxec77	109	21	fevers	fever	NNS
cord-017420-tjwxec77	109	22	persist	persist	VBP
cord-017420-tjwxec77	109	23	for	for	IN
cord-017420-tjwxec77	109	24	72	72	CD
cord-017420-tjwxec77	109	25	-	-	SYM
cord-017420-tjwxec77	109	26	96	96	CD
cord-017420-tjwxec77	109	27	h.	h.	NN
cord-017420-tjwxec77	109	28	Repeat	repeat	VB
cord-017420-tjwxec77	109	29	blood	blood	NN
cord-017420-tjwxec77	109	30	cultures	culture	NNS
cord-017420-tjwxec77	109	31	and	and	CC
cord-017420-tjwxec77	109	32	repeat	repeat	VB
cord-017420-tjwxec77	109	33	or	or	CC
cord-017420-tjwxec77	109	34	expanded	expand	VBN
cord-017420-tjwxec77	109	35	imaging	imaging	NN
cord-017420-tjwxec77	109	36	studies	study	NNS
cord-017420-tjwxec77	109	37	may	may	MD
cord-017420-tjwxec77	109	38	provide	provide	VB
cord-017420-tjwxec77	109	39	additional	additional	JJ
cord-017420-tjwxec77	109	40	diagnostic	diagnostic	JJ
cord-017420-tjwxec77	109	41	information	information	NN
cord-017420-tjwxec77	109	42	.	.	.
cord-017420-tjwxec77	110	1	Risk	risk	NN
cord-017420-tjwxec77	110	2	stratification	stratification	NN
cord-017420-tjwxec77	110	3	is	be	VBZ
cord-017420-tjwxec77	110	4	an	an	DT
cord-017420-tjwxec77	110	5	essential	essential	JJ
cord-017420-tjwxec77	110	6	part	part	NN
cord-017420-tjwxec77	110	7	of	of	IN
cord-017420-tjwxec77	110	8	diagnosis	diagnosis	NN
cord-017420-tjwxec77	110	9	,	,	,
cord-017420-tjwxec77	110	10	as	as	IN
cord-017420-tjwxec77	110	11	it	-PRON-	PRP
cord-017420-tjwxec77	110	12	informs	inform	VBZ
cord-017420-tjwxec77	110	13	immediate	immediate	JJ
cord-017420-tjwxec77	110	14	management	management	NN
cord-017420-tjwxec77	110	15	.	.	.
cord-017420-tjwxec77	111	1	The	the	DT
cord-017420-tjwxec77	111	2	Multinational	Multinational	NNP
cord-017420-tjwxec77	111	3	Association	Association	NNP
cord-017420-tjwxec77	111	4	of	of	IN
cord-017420-tjwxec77	111	5	Supportive	Supportive	NNP
cord-017420-tjwxec77	111	6	Care	Care	NNP
cord-017420-tjwxec77	111	7	in	in	IN
cord-017420-tjwxec77	111	8	Cancer	Cancer	NNP
cord-017420-tjwxec77	111	9	(	(	-LRB-
cord-017420-tjwxec77	111	10	MASCC	MASCC	NNP
cord-017420-tjwxec77	111	11	)	)	-RRB-
cord-017420-tjwxec77	111	12	score	score	NN
cord-017420-tjwxec77	111	13	(	(	-LRB-
cord-017420-tjwxec77	111	14	Table	table	NN
cord-017420-tjwxec77	111	15	4	4	CD
cord-017420-tjwxec77	111	16	)	)	-RRB-
cord-017420-tjwxec77	112	1	[	[	-LRB-
cord-017420-tjwxec77	112	2	35	35	CD
cord-017420-tjwxec77	112	3	]	]	-RRB-
cord-017420-tjwxec77	112	4	was	be	VBD
cord-017420-tjwxec77	112	5	developed	develop	VBN
cord-017420-tjwxec77	112	6	to	to	TO
cord-017420-tjwxec77	112	7	predict	predict	VB
cord-017420-tjwxec77	112	8	which	which	WDT
cord-017420-tjwxec77	112	9	patients	patient	NNS
cord-017420-tjwxec77	112	10	with	with	IN
cord-017420-tjwxec77	112	11	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	112	12	fever	fever	NN
cord-017420-tjwxec77	112	13	may	may	MD
cord-017420-tjwxec77	112	14	be	be	VB
cord-017420-tjwxec77	112	15	safely	safely	RB
cord-017420-tjwxec77	112	16	treated	treat	VBN
cord-017420-tjwxec77	112	17	as	as	IN
cord-017420-tjwxec77	112	18	outpatients	outpatient	NNS
cord-017420-tjwxec77	112	19	.	.	.
cord-017420-tjwxec77	113	1	A	a	DT
cord-017420-tjwxec77	113	2	score	score	NN
cord-017420-tjwxec77	113	3	!	!	.
cord-017420-tjwxec77	114	1	21	21	CD
cord-017420-tjwxec77	114	2	identifies	identify	VBZ
cord-017420-tjwxec77	114	3	a	a	DT
cord-017420-tjwxec77	114	4	standard	standard	JJ
cord-017420-tjwxec77	114	5	risk	risk	NN
cord-017420-tjwxec77	114	6	patient	patient	NN
cord-017420-tjwxec77	114	7	,	,	,
cord-017420-tjwxec77	114	8	whereas	whereas	IN
cord-017420-tjwxec77	114	9	a	a	DT
cord-017420-tjwxec77	114	10	score	score	NN
cord-017420-tjwxec77	114	11	<	<	XX
cord-017420-tjwxec77	114	12	21	21	CD
cord-017420-tjwxec77	114	13	indicates	indicate	VBZ
cord-017420-tjwxec77	114	14	a	a	DT
cord-017420-tjwxec77	114	15	high	high	JJ
cord-017420-tjwxec77	114	16	-	-	HYPH
cord-017420-tjwxec77	114	17	risk	risk	NN
cord-017420-tjwxec77	114	18	patient	patient	NN
cord-017420-tjwxec77	114	19	.	.	.
cord-017420-tjwxec77	115	1	Additional	additional	JJ
cord-017420-tjwxec77	115	2	criteria	criterion	NNS
cord-017420-tjwxec77	115	3	for	for	IN
cord-017420-tjwxec77	115	4	outpatient	outpatient	NN
cord-017420-tjwxec77	115	5	treatment	treatment	NN
cord-017420-tjwxec77	115	6	have	have	VBP
cord-017420-tjwxec77	115	7	been	be	VBN
cord-017420-tjwxec77	115	8	enumerated	enumerate	VBN
cord-017420-tjwxec77	115	9	by	by	IN
cord-017420-tjwxec77	115	10	Heinz	Heinz	NNP
cord-017420-tjwxec77	115	11	et	et	NNP
cord-017420-tjwxec77	115	12	al	al	NNP
cord-017420-tjwxec77	115	13	.	.	.
cord-017420-tjwxec77	116	1	[	[	-LRB-
cord-017420-tjwxec77	116	2	33	33	CD
cord-017420-tjwxec77	116	3	]	]	-RRB-
cord-017420-tjwxec77	116	4	;	;	:
cord-017420-tjwxec77	116	5	these	these	DT
cord-017420-tjwxec77	116	6	focus	focus	NN
cord-017420-tjwxec77	116	7	on	on	IN
cord-017420-tjwxec77	116	8	signs	sign	NNS
cord-017420-tjwxec77	116	9	of	of	IN
cord-017420-tjwxec77	116	10	clinical	clinical	JJ
cord-017420-tjwxec77	116	11	and	and	CC
cord-017420-tjwxec77	116	12	social	social	JJ
cord-017420-tjwxec77	116	13	stability	stability	NN
cord-017420-tjwxec77	116	14	,	,	,
cord-017420-tjwxec77	116	15	with	with	IN
cord-017420-tjwxec77	116	16	particular	particular	JJ
cord-017420-tjwxec77	116	17	emphasis	emphasis	NN
cord-017420-tjwxec77	116	18	placed	place	VBN
cord-017420-tjwxec77	116	19	on	on	IN
cord-017420-tjwxec77	116	20	expected	expect	VBN
cord-017420-tjwxec77	116	21	good	good	JJ
cord-017420-tjwxec77	116	22	adherence	adherence	NN
cord-017420-tjwxec77	116	23	to	to	IN
cord-017420-tjwxec77	116	24	oral	oral	JJ
cord-017420-tjwxec77	116	25	medications	medication	NNS
cord-017420-tjwxec77	116	26	,	,	,
cord-017420-tjwxec77	116	27	adequate	adequate	JJ
cord-017420-tjwxec77	116	28	social	social	JJ
cord-017420-tjwxec77	116	29	support	support	NN
cord-017420-tjwxec77	116	30	(	(	-LRB-
cord-017420-tjwxec77	116	31	the	the	DT
cord-017420-tjwxec77	116	32	patient	patient	NN
cord-017420-tjwxec77	116	33	does	do	VBZ
cord-017420-tjwxec77	116	34	not	not	RB
cord-017420-tjwxec77	116	35	live	live	VB
cord-017420-tjwxec77	116	36	alone	alone	RB
cord-017420-tjwxec77	116	37	)	)	-RRB-
cord-017420-tjwxec77	116	38	,	,	,
cord-017420-tjwxec77	116	39	and	and	CC
cord-017420-tjwxec77	116	40	the	the	DT
cord-017420-tjwxec77	116	41	ability	ability	NN
cord-017420-tjwxec77	116	42	to	to	TO
cord-017420-tjwxec77	116	43	present	present	VB
cord-017420-tjwxec77	116	44	to	to	IN
cord-017420-tjwxec77	116	45	the	the	DT
cord-017420-tjwxec77	116	46	hospital	hospital	NN
cord-017420-tjwxec77	116	47	within	within	IN
cord-017420-tjwxec77	116	48	60	60	CD
cord-017420-tjwxec77	116	49	min	min	NN
cord-017420-tjwxec77	116	50	.	.	.
cord-017420-tjwxec77	117	1	It	-PRON-	PRP
cord-017420-tjwxec77	117	2	should	should	MD
cord-017420-tjwxec77	117	3	be	be	VB
cord-017420-tjwxec77	117	4	noted	note	VBN
cord-017420-tjwxec77	117	5	that	that	IN
cord-017420-tjwxec77	117	6	the	the	DT
cord-017420-tjwxec77	117	7	MASCC	MASCC	NNP
cord-017420-tjwxec77	117	8	score	score	NN
cord-017420-tjwxec77	117	9	has	have	VBZ
cord-017420-tjwxec77	117	10	limited	limit	VBN
cord-017420-tjwxec77	117	11	utility	utility	NN
cord-017420-tjwxec77	117	12	in	in	IN
cord-017420-tjwxec77	117	13	predicting	predict	VBG
cord-017420-tjwxec77	117	14	either	either	CC
cord-017420-tjwxec77	117	15	the	the	DT
cord-017420-tjwxec77	117	16	risk	risk	NN
cord-017420-tjwxec77	117	17	of	of	IN
cord-017420-tjwxec77	117	18	critical	critical	JJ
cord-017420-tjwxec77	117	19	illness	illness	NN
cord-017420-tjwxec77	117	20	or	or	CC
cord-017420-tjwxec77	117	21	ICU	ICU	NNP
cord-017420-tjwxec77	117	22	outcomes	outcome	NNS
cord-017420-tjwxec77	117	23	.	.	.
cord-017420-tjwxec77	118	1	Other	other	JJ
cord-017420-tjwxec77	118	2	factors	factor	NNS
cord-017420-tjwxec77	118	3	which	which	WDT
cord-017420-tjwxec77	118	4	influence	influence	VBP
cord-017420-tjwxec77	118	5	risk	risk	NN
cord-017420-tjwxec77	118	6	stratification	stratification	NN
cord-017420-tjwxec77	118	7	include	include	VBP
cord-017420-tjwxec77	118	8	the	the	DT
cord-017420-tjwxec77	118	9	depth	depth	NN
cord-017420-tjwxec77	118	10	and	and	CC
cord-017420-tjwxec77	118	11	duration	duration	NN
cord-017420-tjwxec77	118	12	of	of	IN
cord-017420-tjwxec77	118	13	neutropenia	neutropenia	NN
cord-017420-tjwxec77	118	14	,	,	,
cord-017420-tjwxec77	118	15	with	with	IN
cord-017420-tjwxec77	118	16	an	an	DT
cord-017420-tjwxec77	118	17	ANC	ANC	NNP
cord-017420-tjwxec77	118	18	100	100	CD
cord-017420-tjwxec77	118	19	cells	cell	NNS
cord-017420-tjwxec77	118	20	/	/	SYM
cord-017420-tjwxec77	118	21	mm	mm	NNP
cord-017420-tjwxec77	118	22	3	3	CD
cord-017420-tjwxec77	118	23	and	and	CC
cord-017420-tjwxec77	118	24	>	>	XX
cord-017420-tjwxec77	118	25	7	7	CD
cord-017420-tjwxec77	118	26	days	day	NNS
cord-017420-tjwxec77	118	27	duration	duration	NN
cord-017420-tjwxec77	118	28	,	,	,
cord-017420-tjwxec77	118	29	respectively	respectively	RB
cord-017420-tjwxec77	118	30	,	,	,
cord-017420-tjwxec77	118	31	being	be	VBG
cord-017420-tjwxec77	118	32	markers	marker	NNS
cord-017420-tjwxec77	118	33	of	of	IN
cord-017420-tjwxec77	118	34	a	a	DT
cord-017420-tjwxec77	118	35	high	high	JJ
cord-017420-tjwxec77	118	36	-	-	HYPH
cord-017420-tjwxec77	118	37	risk	risk	NN
cord-017420-tjwxec77	118	38	patient	patient	NN
cord-017420-tjwxec77	118	39	[	[	-LRB-
cord-017420-tjwxec77	118	40	28	28	CD
cord-017420-tjwxec77	118	41	]	]	-RRB-
cord-017420-tjwxec77	118	42	.	.	.
cord-017420-tjwxec77	119	1	Accordingly	accordingly	RB
cord-017420-tjwxec77	119	2	,	,	,
cord-017420-tjwxec77	119	3	neutropenic	neutropenic	RB
cord-017420-tjwxec77	119	4	Modified	modify	VBN
cord-017420-tjwxec77	119	5	from	from	IN
cord-017420-tjwxec77	119	6	[	[	-LRB-
cord-017420-tjwxec77	119	7	35	35	CD
cord-017420-tjwxec77	119	8	]	]	-RRB-
cord-017420-tjwxec77	119	9	patients	patient	NNS
cord-017420-tjwxec77	119	10	with	with	IN
cord-017420-tjwxec77	119	11	a	a	DT
cord-017420-tjwxec77	119	12	hematologic	hematologic	JJ
cord-017420-tjwxec77	119	13	malignancy	malignancy	NN
cord-017420-tjwxec77	119	14	or	or	CC
cord-017420-tjwxec77	119	15	status	status	NN
cord-017420-tjwxec77	119	16	post	post	NN
cord-017420-tjwxec77	120	1	HSCT	HSCT	NNP
cord-017420-tjwxec77	120	2	are	be	VBP
cord-017420-tjwxec77	120	3	almost	almost	RB
cord-017420-tjwxec77	120	4	always	always	RB
cord-017420-tjwxec77	120	5	higher	high	JJR
cord-017420-tjwxec77	120	6	risk	risk	NN
cord-017420-tjwxec77	120	7	than	than	IN
cord-017420-tjwxec77	120	8	patients	patient	NNS
cord-017420-tjwxec77	120	9	who	who	WP
cord-017420-tjwxec77	120	10	become	become	VBP
cord-017420-tjwxec77	120	11	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	120	12	during	during	IN
cord-017420-tjwxec77	120	13	the	the	DT
cord-017420-tjwxec77	120	14	course	course	NN
cord-017420-tjwxec77	120	15	of	of	IN
cord-017420-tjwxec77	120	16	cyclic	cyclic	JJ
cord-017420-tjwxec77	120	17	treatment	treatment	NN
cord-017420-tjwxec77	120	18	for	for	IN
cord-017420-tjwxec77	120	19	a	a	DT
cord-017420-tjwxec77	120	20	solid	solid	JJ
cord-017420-tjwxec77	120	21	malignancy	malignancy	NN
cord-017420-tjwxec77	120	22	.	.	.
cord-017420-tjwxec77	121	1	Comorbid	comorbid	NN
cord-017420-tjwxec77	121	2	conditions	condition	NNS
cord-017420-tjwxec77	121	3	should	should	MD
cord-017420-tjwxec77	121	4	also	also	RB
cord-017420-tjwxec77	121	5	be	be	VB
cord-017420-tjwxec77	121	6	integrated	integrate	VBN
cord-017420-tjwxec77	121	7	into	into	IN
cord-017420-tjwxec77	121	8	any	any	DT
cord-017420-tjwxec77	121	9	clinical	clinical	JJ
cord-017420-tjwxec77	121	10	risk	risk	NN
cord-017420-tjwxec77	121	11	assessment	assessment	NN
cord-017420-tjwxec77	121	12	.	.	.
cord-017420-tjwxec77	122	1	Pharmacologic	Pharmacologic	NNP
cord-017420-tjwxec77	122	2	Prophylaxis	Prophylaxis	NNP
cord-017420-tjwxec77	122	3	in	in	IN
cord-017420-tjwxec77	122	4	Neutropenic	Neutropenic	NNP
cord-017420-tjwxec77	122	5	Patients	Patients	NNPS
cord-017420-tjwxec77	122	6	Before	before	IN
cord-017420-tjwxec77	122	7	Neutropenic	Neutropenic	NNP
cord-017420-tjwxec77	122	8	Fever	Fever	NNP
cord-017420-tjwxec77	122	9	Develops	develop	VBZ
cord-017420-tjwxec77	122	10	Due	due	IN
cord-017420-tjwxec77	122	11	to	to	IN
cord-017420-tjwxec77	122	12	the	the	DT
cord-017420-tjwxec77	122	13	high	high	JJ
cord-017420-tjwxec77	122	14	risk	risk	NN
cord-017420-tjwxec77	122	15	of	of	IN
cord-017420-tjwxec77	122	16	infection	infection	NN
cord-017420-tjwxec77	122	17	in	in	IN
cord-017420-tjwxec77	122	18	neutropenia	neutropenia	NN
cord-017420-tjwxec77	122	19	,	,	,
cord-017420-tjwxec77	122	20	many	many	JJ
cord-017420-tjwxec77	122	21	centers	center	NNS
cord-017420-tjwxec77	122	22	provide	provide	VBP
cord-017420-tjwxec77	122	23	routine	routine	JJ
cord-017420-tjwxec77	122	24	antimicrobial	antimicrobial	JJ
cord-017420-tjwxec77	122	25	prophylaxis	prophylaxis	NN
cord-017420-tjwxec77	122	26	to	to	IN
cord-017420-tjwxec77	122	27	patients	patient	NNS
cord-017420-tjwxec77	122	28	deemed	deem	VBN
cord-017420-tjwxec77	122	29	to	to	TO
cord-017420-tjwxec77	122	30	be	be	VB
cord-017420-tjwxec77	122	31	at	at	IN
cord-017420-tjwxec77	122	32	high	high	JJ
cord-017420-tjwxec77	122	33	risk	risk	NN
cord-017420-tjwxec77	122	34	for	for	IN
cord-017420-tjwxec77	122	35	infection	infection	NN
cord-017420-tjwxec77	122	36	and	and	CC
cord-017420-tjwxec77	122	37	who	who	WP
cord-017420-tjwxec77	122	38	are	be	VBP
cord-017420-tjwxec77	122	39	expected	expect	VBN
cord-017420-tjwxec77	122	40	to	to	TO
cord-017420-tjwxec77	122	41	have	have	VB
cord-017420-tjwxec77	122	42	prolonged	prolong	VBN
cord-017420-tjwxec77	122	43	periods	period	NNS
cord-017420-tjwxec77	122	44	of	of	IN
cord-017420-tjwxec77	122	45	profound	profound	JJ
cord-017420-tjwxec77	122	46	neutropenia	neutropenia	NN
cord-017420-tjwxec77	122	47	(	(	-LRB-
cord-017420-tjwxec77	122	48	e.g.	e.g.	RB
cord-017420-tjwxec77	122	49	,	,	,
cord-017420-tjwxec77	122	50	ANC	ANC	NNP
cord-017420-tjwxec77	122	51	500	500	CD
cord-017420-tjwxec77	122	52	cells	cell	NNS
cord-017420-tjwxec77	122	53	/	/	SYM
cord-017420-tjwxec77	122	54	mm	mm	NN
cord-017420-tjwxec77	122	55	3	3	CD
cord-017420-tjwxec77	122	56	for	for	IN
cord-017420-tjwxec77	122	57	>	>	$
cord-017420-tjwxec77	122	58	7	7	CD
cord-017420-tjwxec77	122	59	days	day	NNS
cord-017420-tjwxec77	122	60	)	)	-RRB-
cord-017420-tjwxec77	122	61	.	.	.
cord-017420-tjwxec77	123	1	The	the	DT
cord-017420-tjwxec77	123	2	rationale	rationale	NN
cord-017420-tjwxec77	123	3	for	for	IN
cord-017420-tjwxec77	123	4	antibacterial	antibacterial	JJ
cord-017420-tjwxec77	123	5	prophylaxis	prophylaxis	NN
cord-017420-tjwxec77	123	6	is	be	VBZ
cord-017420-tjwxec77	123	7	to	to	TO
cord-017420-tjwxec77	123	8	reduce	reduce	VB
cord-017420-tjwxec77	123	9	the	the	DT
cord-017420-tjwxec77	123	10	risk	risk	NN
cord-017420-tjwxec77	123	11	of	of	IN
cord-017420-tjwxec77	123	12	gram	gram	NN
cord-017420-tjwxec77	123	13	-	-	HYPH
cord-017420-tjwxec77	123	14	negative	negative	JJ
cord-017420-tjwxec77	123	15	infections	infection	NNS
cord-017420-tjwxec77	123	16	and	and	CC
cord-017420-tjwxec77	123	17	streptococcal	streptococcal	JJ
cord-017420-tjwxec77	123	18	infection	infection	NN
cord-017420-tjwxec77	123	19	from	from	IN
cord-017420-tjwxec77	123	20	oral	oral	JJ
cord-017420-tjwxec77	123	21	mucositis	mucositis	NNP
cord-017420-tjwxec77	123	22	.	.	.
cord-017420-tjwxec77	124	1	In	in	IN
cord-017420-tjwxec77	124	2	high	high	JJ
cord-017420-tjwxec77	124	3	-	-	HYPH
cord-017420-tjwxec77	124	4	risk	risk	NN
cord-017420-tjwxec77	124	5	patients	patient	NNS
cord-017420-tjwxec77	124	6	,	,	,
cord-017420-tjwxec77	124	7	current	current	JJ
cord-017420-tjwxec77	124	8	guidelines	guideline	NNS
cord-017420-tjwxec77	124	9	suggest	suggest	VBP
cord-017420-tjwxec77	124	10	antibacterial	antibacterial	JJ
cord-017420-tjwxec77	124	11	prophylaxis	prophylaxis	NN
cord-017420-tjwxec77	124	12	with	with	IN
cord-017420-tjwxec77	124	13	a	a	DT
cord-017420-tjwxec77	124	14	fluoroquinolone	fluoroquinolone	NN
cord-017420-tjwxec77	124	15	such	such	JJ
cord-017420-tjwxec77	124	16	as	as	IN
cord-017420-tjwxec77	124	17	ciprofloxacin	ciprofloxacin	NN
cord-017420-tjwxec77	124	18	or	or	CC
cord-017420-tjwxec77	124	19	levofloxacin	levofloxacin	NNS
cord-017420-tjwxec77	124	20	,	,	,
cord-017420-tjwxec77	124	21	with	with	IN
cord-017420-tjwxec77	124	22	the	the	DT
cord-017420-tjwxec77	124	23	latter	latter	JJ
cord-017420-tjwxec77	124	24	preferred	prefer	VBN
cord-017420-tjwxec77	124	25	if	if	IN
cord-017420-tjwxec77	124	26	severe	severe	JJ
cord-017420-tjwxec77	124	27	mucositis	mucositis	NNP
cord-017420-tjwxec77	124	28	is	be	VBZ
cord-017420-tjwxec77	124	29	anticipated	anticipate	VBN
cord-017420-tjwxec77	124	30	[	[	-LRB-
cord-017420-tjwxec77	124	31	29	29	CD
cord-017420-tjwxec77	124	32	,	,	,
cord-017420-tjwxec77	124	33	30	30	CD
cord-017420-tjwxec77	124	34	]	]	-RRB-
cord-017420-tjwxec77	124	35	.	.	.
cord-017420-tjwxec77	125	1	Antifungal	antifungal	JJ
cord-017420-tjwxec77	125	2	prophylaxis	prophylaxis	NN
cord-017420-tjwxec77	125	3	against	against	IN
cord-017420-tjwxec77	125	4	yeast	yeast	NN
cord-017420-tjwxec77	125	5	is	be	VBZ
cord-017420-tjwxec77	125	6	recommended	recommend	VBN
cord-017420-tjwxec77	125	7	in	in	IN
cord-017420-tjwxec77	125	8	highrisk	highrisk	JJ
cord-017420-tjwxec77	125	9	patients	patient	NNS
cord-017420-tjwxec77	125	10	(	(	-LRB-
cord-017420-tjwxec77	125	11	HSCT	HSCT	NNP
cord-017420-tjwxec77	125	12	,	,	,
cord-017420-tjwxec77	125	13	chemotherapy	chemotherapy	NN
cord-017420-tjwxec77	125	14	for	for	IN
cord-017420-tjwxec77	125	15	leukemia	leukemia	NN
cord-017420-tjwxec77	125	16	)	)	-RRB-
cord-017420-tjwxec77	125	17	with	with	IN
cord-017420-tjwxec77	125	18	fluconazole	fluconazole	NNP
cord-017420-tjwxec77	125	19	,	,	,
cord-017420-tjwxec77	125	20	itraconazole	itraconazole	NNP
cord-017420-tjwxec77	125	21	,	,	,
cord-017420-tjwxec77	125	22	voriconazole	voriconazole	NNP
cord-017420-tjwxec77	125	23	,	,	,
cord-017420-tjwxec77	125	24	posaconazole	posaconazole	NNP
cord-017420-tjwxec77	125	25	,	,	,
cord-017420-tjwxec77	125	26	or	or	CC
cord-017420-tjwxec77	125	27	an	an	DT
cord-017420-tjwxec77	125	28	echinocandin	echinocandin	NN
cord-017420-tjwxec77	125	29	(	(	-LRB-
cord-017420-tjwxec77	125	30	caspofungin	caspofungin	NNP
cord-017420-tjwxec77	125	31	or	or	CC
cord-017420-tjwxec77	125	32	micafungin	micafungin	NNP
cord-017420-tjwxec77	125	33	)	)	-RRB-
cord-017420-tjwxec77	125	34	.	.	.
cord-017420-tjwxec77	126	1	Anti	anti	JJ
cord-017420-tjwxec77	126	2	-	-	JJ
cord-017420-tjwxec77	126	3	mold	mold	JJ
cord-017420-tjwxec77	126	4	(	(	-LRB-
cord-017420-tjwxec77	126	5	Aspergillus	aspergillus	NN
cord-017420-tjwxec77	126	6	)	)	-RRB-
cord-017420-tjwxec77	126	7	prophylaxis	prophylaxis	NN
cord-017420-tjwxec77	126	8	(	(	-LRB-
cord-017420-tjwxec77	126	9	with	with	IN
cord-017420-tjwxec77	126	10	voriconazole	voriconazole	NNP
cord-017420-tjwxec77	126	11	or	or	CC
cord-017420-tjwxec77	126	12	posaconazole	posaconazole	NNP
cord-017420-tjwxec77	126	13	)	)	-RRB-
cord-017420-tjwxec77	126	14	is	be	VBZ
cord-017420-tjwxec77	126	15	recommended	recommend	VBN
cord-017420-tjwxec77	126	16	in	in	IN
cord-017420-tjwxec77	126	17	patients	patient	NNS
cord-017420-tjwxec77	126	18	undergoing	undergo	VBG
cord-017420-tjwxec77	126	19	chemotherapy	chemotherapy	NN
cord-017420-tjwxec77	126	20	for	for	IN
cord-017420-tjwxec77	126	21	leukemia	leukemia	NN
cord-017420-tjwxec77	126	22	or	or	CC
cord-017420-tjwxec77	126	23	patients	patient	NNS
cord-017420-tjwxec77	126	24	with	with	IN
cord-017420-tjwxec77	126	25	anticipated	anticipate	VBN
cord-017420-tjwxec77	126	26	very	very	RB
cord-017420-tjwxec77	126	27	prolonged	prolonged	JJ
cord-017420-tjwxec77	126	28	neutropenia	neutropenia	NN
cord-017420-tjwxec77	126	29	or	or	CC
cord-017420-tjwxec77	126	30	prior	prior	JJ
cord-017420-tjwxec77	126	31	invasive	invasive	JJ
cord-017420-tjwxec77	126	32	mold	mold	NN
cord-017420-tjwxec77	126	33	infection	infection	NN
cord-017420-tjwxec77	126	34	[	[	-LRB-
cord-017420-tjwxec77	126	35	28	28	CD
cord-017420-tjwxec77	126	36	]	]	-RRB-
cord-017420-tjwxec77	126	37	.	.	.
cord-017420-tjwxec77	127	1	Antiviral	antiviral	JJ
cord-017420-tjwxec77	127	2	prophylaxis	prophylaxis	NN
cord-017420-tjwxec77	127	3	acyclovir	acyclovir	NNP
cord-017420-tjwxec77	127	4	or	or	CC
cord-017420-tjwxec77	127	5	valacyclovir	valacyclovir	NNP
cord-017420-tjwxec77	127	6	is	be	VBZ
cord-017420-tjwxec77	127	7	recommended	recommend	VBN
cord-017420-tjwxec77	127	8	for	for	IN
cord-017420-tjwxec77	127	9	patients	patient	NNS
cord-017420-tjwxec77	127	10	who	who	WP
cord-017420-tjwxec77	127	11	are	be	VBP
cord-017420-tjwxec77	127	12	seropositive	seropositive	JJ
cord-017420-tjwxec77	127	13	for	for	IN
cord-017420-tjwxec77	127	14	herpes	herpes	NN
cord-017420-tjwxec77	127	15	simplex	simplex	NNP
cord-017420-tjwxec77	127	16	virus	virus	NN
cord-017420-tjwxec77	127	17	(	(	-LRB-
cord-017420-tjwxec77	127	18	HSV	HSV	NNP
cord-017420-tjwxec77	127	19	)	)	-RRB-
cord-017420-tjwxec77	127	20	and	and	CC
cord-017420-tjwxec77	127	21	for	for	IN
cord-017420-tjwxec77	127	22	varicella	varicella	NN
cord-017420-tjwxec77	127	23	zoster	zoster	NNP
cord-017420-tjwxec77	127	24	virus	virus	NN
cord-017420-tjwxec77	127	25	(	(	-LRB-
cord-017420-tjwxec77	127	26	VZV)-seropositive	vzv)-seropositive	IN
cord-017420-tjwxec77	127	27	HSCT	HSCT	NNP
cord-017420-tjwxec77	127	28	patients	patient	NNS
cord-017420-tjwxec77	127	29	.	.	.
cord-017420-tjwxec77	128	1	Finally	finally	RB
cord-017420-tjwxec77	128	2	,	,	,
cord-017420-tjwxec77	128	3	leukemia	leukemia	NN
cord-017420-tjwxec77	128	4	and	and	CC
cord-017420-tjwxec77	128	5	HSCT	HSCT	NNP
cord-017420-tjwxec77	128	6	patients	patient	NNS
cord-017420-tjwxec77	128	7	should	should	MD
cord-017420-tjwxec77	128	8	receive	receive	VB
cord-017420-tjwxec77	128	9	prophylaxis	prophylaxis	NN
cord-017420-tjwxec77	128	10	against	against	IN
cord-017420-tjwxec77	128	11	Pneumocystis	Pneumocystis	NNP
cord-017420-tjwxec77	128	12	jirovecii	jirovecii	NNP
cord-017420-tjwxec77	128	13	pneumonia	pneumonia	NN
cord-017420-tjwxec77	128	14	.	.	.
cord-017420-tjwxec77	129	1	These	these	DT
cord-017420-tjwxec77	129	2	prophylactic	prophylactic	JJ
cord-017420-tjwxec77	129	3	antimicrobials	antimicrobial	NNS
cord-017420-tjwxec77	129	4	may	may	MD
cord-017420-tjwxec77	129	5	lessen	lessen	VB
cord-017420-tjwxec77	129	6	,	,	,
cord-017420-tjwxec77	129	7	but	but	CC
cord-017420-tjwxec77	129	8	do	do	VBP
cord-017420-tjwxec77	129	9	not	not	RB
cord-017420-tjwxec77	129	10	eliminate	eliminate	VB
cord-017420-tjwxec77	129	11	the	the	DT
cord-017420-tjwxec77	129	12	risk	risk	NN
cord-017420-tjwxec77	129	13	infections	infection	NNS
cord-017420-tjwxec77	129	14	while	while	IN
cord-017420-tjwxec77	129	15	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	129	16	;	;	:
cord-017420-tjwxec77	129	17	thus	thus	RB
cord-017420-tjwxec77	129	18	,	,	,
cord-017420-tjwxec77	129	19	patients	patient	NNS
cord-017420-tjwxec77	129	20	and	and	CC
cord-017420-tjwxec77	129	21	caregivers	caregiver	NNS
cord-017420-tjwxec77	129	22	must	must	MD
cord-017420-tjwxec77	129	23	remain	remain	VB
cord-017420-tjwxec77	129	24	vigilant	vigilant	JJ
cord-017420-tjwxec77	129	25	for	for	IN
cord-017420-tjwxec77	129	26	the	the	DT
cord-017420-tjwxec77	129	27	development	development	NN
cord-017420-tjwxec77	129	28	of	of	IN
cord-017420-tjwxec77	129	29	fever	fever	NN
cord-017420-tjwxec77	129	30	.	.	.
cord-017420-tjwxec77	130	1	Moreover	moreover	RB
cord-017420-tjwxec77	130	2	,	,	,
cord-017420-tjwxec77	130	3	attention	attention	NN
cord-017420-tjwxec77	130	4	must	must	MD
cord-017420-tjwxec77	130	5	be	be	VB
cord-017420-tjwxec77	130	6	paid	pay	VBN
cord-017420-tjwxec77	130	7	to	to	IN
cord-017420-tjwxec77	130	8	the	the	DT
cord-017420-tjwxec77	130	9	prophylactic	prophylactic	JJ
cord-017420-tjwxec77	130	10	regimen	regimen	NN
cord-017420-tjwxec77	130	11	,	,	,
cord-017420-tjwxec77	130	12	as	as	IN
cord-017420-tjwxec77	130	13	it	-PRON-	PRP
cord-017420-tjwxec77	130	14	will	will	MD
cord-017420-tjwxec77	130	15	affect	affect	VB
cord-017420-tjwxec77	130	16	the	the	DT
cord-017420-tjwxec77	130	17	choice	choice	NN
cord-017420-tjwxec77	130	18	of	of	IN
cord-017420-tjwxec77	130	19	empiric	empiric	JJ
cord-017420-tjwxec77	130	20	antibiotics	antibiotic	NNS
cord-017420-tjwxec77	130	21	for	for	IN
cord-017420-tjwxec77	130	22	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	130	23	fever	fever	NN
cord-017420-tjwxec77	130	24	.	.	.
cord-017420-tjwxec77	131	1	Neutropenic	neutropenic	JJ
cord-017420-tjwxec77	131	2	fever	fever	NN
cord-017420-tjwxec77	131	3	is	be	VBZ
cord-017420-tjwxec77	131	4	a	a	DT
cord-017420-tjwxec77	131	5	medical	medical	JJ
cord-017420-tjwxec77	131	6	emergency	emergency	NN
cord-017420-tjwxec77	131	7	,	,	,
cord-017420-tjwxec77	131	8	and	and	CC
cord-017420-tjwxec77	131	9	appropriate	appropriate	JJ
cord-017420-tjwxec77	131	10	empiric	empiric	JJ
cord-017420-tjwxec77	131	11	antibiotics	antibiotic	NNS
cord-017420-tjwxec77	131	12	must	must	MD
cord-017420-tjwxec77	131	13	be	be	VB
cord-017420-tjwxec77	131	14	started	start	VBN
cord-017420-tjwxec77	131	15	without	without	IN
cord-017420-tjwxec77	131	16	delay	delay	NN
cord-017420-tjwxec77	131	17	:	:	:
cord-017420-tjwxec77	131	18	within	within	IN
cord-017420-tjwxec77	131	19	60	60	CD
cord-017420-tjwxec77	131	20	min	min	NN
cord-017420-tjwxec77	131	21	of	of	IN
cord-017420-tjwxec77	131	22	presentation	presentation	NN
cord-017420-tjwxec77	131	23	[	[	-LRB-
cord-017420-tjwxec77	131	24	28	28	CD
cord-017420-tjwxec77	131	25	,	,	,
cord-017420-tjwxec77	131	26	33	33	CD
cord-017420-tjwxec77	131	27	,	,	,
cord-017420-tjwxec77	131	28	57	57	CD
cord-017420-tjwxec77	131	29	]	]	-RRB-
cord-017420-tjwxec77	131	30	.	.	.
cord-017420-tjwxec77	132	1	Some	some	DT
cord-017420-tjwxec77	132	2	data	datum	NNS
cord-017420-tjwxec77	132	3	suggest	suggest	VBP
cord-017420-tjwxec77	132	4	that	that	IN
cord-017420-tjwxec77	132	5	even	even	RB
cord-017420-tjwxec77	132	6	delays	delay	NNS
cord-017420-tjwxec77	132	7	in	in	IN
cord-017420-tjwxec77	132	8	antibiotic	antibiotic	JJ
cord-017420-tjwxec77	132	9	administration	administration	NN
cord-017420-tjwxec77	132	10	beyond	beyond	IN
cord-017420-tjwxec77	132	11	30	30	CD
cord-017420-tjwxec77	132	12	min	min	NN
cord-017420-tjwxec77	132	13	are	be	VBP
cord-017420-tjwxec77	132	14	associated	associate	VBN
cord-017420-tjwxec77	132	15	with	with	IN
cord-017420-tjwxec77	132	16	increased	increase	VBN
cord-017420-tjwxec77	132	17	mortality	mortality	NN
cord-017420-tjwxec77	132	18	[	[	-LRB-
cord-017420-tjwxec77	132	19	62	62	CD
cord-017420-tjwxec77	132	20	]	]	-RRB-
cord-017420-tjwxec77	132	21	.	.	.
cord-017420-tjwxec77	133	1	As	as	IN
cord-017420-tjwxec77	133	2	noted	note	VBN
cord-017420-tjwxec77	133	3	above	above	RB
cord-017420-tjwxec77	133	4	,	,	,
cord-017420-tjwxec77	133	5	it	-PRON-	PRP
cord-017420-tjwxec77	133	6	is	be	VBZ
cord-017420-tjwxec77	133	7	desirable	desirable	JJ
cord-017420-tjwxec77	133	8	to	to	TO
cord-017420-tjwxec77	133	9	obtain	obtain	VB
cord-017420-tjwxec77	133	10	blood	blood	NN
cord-017420-tjwxec77	133	11	cultures	culture	NNS
cord-017420-tjwxec77	133	12	if	if	IN
cord-017420-tjwxec77	133	13	possible	possible	JJ
cord-017420-tjwxec77	133	14	before	before	IN
cord-017420-tjwxec77	133	15	antibiotic	antibiotic	JJ
cord-017420-tjwxec77	133	16	initiation	initiation	NN
cord-017420-tjwxec77	133	17	,	,	,
cord-017420-tjwxec77	133	18	so	so	RB
cord-017420-tjwxec77	133	19	long	long	RB
cord-017420-tjwxec77	133	20	as	as	IN
cord-017420-tjwxec77	133	21	this	this	DT
cord-017420-tjwxec77	133	22	does	do	VBZ
cord-017420-tjwxec77	133	23	not	not	RB
cord-017420-tjwxec77	133	24	delay	delay	VB
cord-017420-tjwxec77	133	25	antibiotic	antibiotic	JJ
cord-017420-tjwxec77	133	26	administration	administration	NN
cord-017420-tjwxec77	133	27	.	.	.
cord-017420-tjwxec77	134	1	No	no	DT
cord-017420-tjwxec77	134	2	other	other	JJ
cord-017420-tjwxec77	134	3	diagnostic	diagnostic	JJ
cord-017420-tjwxec77	134	4	maneuvers	maneuver	NNS
cord-017420-tjwxec77	134	5	should	should	MD
cord-017420-tjwxec77	134	6	be	be	VB
cord-017420-tjwxec77	134	7	attempted	attempt	VBN
cord-017420-tjwxec77	134	8	before	before	IN
cord-017420-tjwxec77	134	9	antibiotic	antibiotic	JJ
cord-017420-tjwxec77	134	10	initiation	initiation	NN
cord-017420-tjwxec77	134	11	.	.	.
cord-017420-tjwxec77	135	1	Empiric	Empiric	NNP
cord-017420-tjwxec77	135	2	antibiotics	antibiotic	NNS
cord-017420-tjwxec77	135	3	must	must	MD
cord-017420-tjwxec77	135	4	cover	cover	VB
cord-017420-tjwxec77	135	5	the	the	DT
cord-017420-tjwxec77	135	6	common	common	JJ
cord-017420-tjwxec77	135	7	organisms	organism	NNS
cord-017420-tjwxec77	135	8	discussed	discuss	VBN
cord-017420-tjwxec77	135	9	above	above	IN
cord-017420-tjwxec77	135	10	(	(	-LRB-
cord-017420-tjwxec77	135	11	Pseudomonas	Pseudomonas	NNP
cord-017420-tjwxec77	135	12	aeruginosa	aeruginosa	NN
cord-017420-tjwxec77	135	13	,	,	,
cord-017420-tjwxec77	135	14	Staphylococcus	Staphylococcus	NNP
cord-017420-tjwxec77	135	15	aureus	aureus	NN
cord-017420-tjwxec77	135	16	,	,	,
cord-017420-tjwxec77	135	17	Streptococcal	Streptococcal	NNP
cord-017420-tjwxec77	135	18	species	specie	NNS
cord-017420-tjwxec77	135	19	)	)	-RRB-
cord-017420-tjwxec77	135	20	and	and	CC
cord-017420-tjwxec77	135	21	should	should	MD
cord-017420-tjwxec77	135	22	also	also	RB
cord-017420-tjwxec77	135	23	be	be	VB
cord-017420-tjwxec77	135	24	tailored	tailor	VBN
cord-017420-tjwxec77	135	25	according	accord	VBG
cord-017420-tjwxec77	135	26	to	to	IN
cord-017420-tjwxec77	135	27	prior	prior	JJ
cord-017420-tjwxec77	135	28	patient	patient	NN
cord-017420-tjwxec77	135	29	-	-	HYPH
cord-017420-tjwxec77	135	30	specific	specific	JJ
cord-017420-tjwxec77	135	31	culture	culture	NN
cord-017420-tjwxec77	135	32	data	datum	NNS
cord-017420-tjwxec77	135	33	and	and	CC
cord-017420-tjwxec77	135	34	institutional	institutional	JJ
cord-017420-tjwxec77	135	35	epidemiology	epidemiology	NN
cord-017420-tjwxec77	135	36	[	[	-LRB-
cord-017420-tjwxec77	135	37	28	28	CD
cord-017420-tjwxec77	135	38	,	,	,
cord-017420-tjwxec77	135	39	33	33	CD
cord-017420-tjwxec77	135	40	]	]	-RRB-
cord-017420-tjwxec77	135	41	.	.	.
cord-017420-tjwxec77	136	1	Appropriate	appropriate	JJ
cord-017420-tjwxec77	136	2	empiric	empiric	JJ
cord-017420-tjwxec77	136	3	antibiotics	antibiotic	NNS
cord-017420-tjwxec77	136	4	include	include	VBP
cord-017420-tjwxec77	136	5	an	an	DT
cord-017420-tjwxec77	136	6	antipseudomonal	antipseudomonal	JJ
cord-017420-tjwxec77	136	7	penicillin	penicillin	NN
cord-017420-tjwxec77	136	8	(	(	-LRB-
cord-017420-tjwxec77	136	9	e.g.	e.g.	RB
cord-017420-tjwxec77	136	10	,	,	,
cord-017420-tjwxec77	136	11	piperacillin/	piperacillin/	CD
cord-017420-tjwxec77	136	12	tazobactam	tazobactam	NNP
cord-017420-tjwxec77	136	13	)	)	-RRB-
cord-017420-tjwxec77	136	14	,	,	,
cord-017420-tjwxec77	136	15	or	or	CC
cord-017420-tjwxec77	136	16	antipseudomonal	antipseudomonal	JJ
cord-017420-tjwxec77	136	17	cephalosporin	cephalosporin	NN
cord-017420-tjwxec77	136	18	(	(	-LRB-
cord-017420-tjwxec77	136	19	e.g.	e.g.	RB
cord-017420-tjwxec77	136	20	,	,	,
cord-017420-tjwxec77	136	21	cefepime	cefepime	NNP
cord-017420-tjwxec77	136	22	)	)	-RRB-
cord-017420-tjwxec77	136	23	,	,	,
cord-017420-tjwxec77	136	24	or	or	CC
cord-017420-tjwxec77	136	25	a	a	DT
cord-017420-tjwxec77	136	26	carbapenem	carbapenem	NNP
cord-017420-tjwxec77	136	27	(	(	-LRB-
cord-017420-tjwxec77	136	28	imipenem	imipenem	NNP
cord-017420-tjwxec77	136	29	,	,	,
cord-017420-tjwxec77	136	30	meropenem	meropenem	NNP
cord-017420-tjwxec77	136	31	)	)	-RRB-
cord-017420-tjwxec77	136	32	[	[	-LRB-
cord-017420-tjwxec77	136	33	28	28	CD
cord-017420-tjwxec77	136	34	,	,	,
cord-017420-tjwxec77	136	35	33	33	CD
cord-017420-tjwxec77	136	36	]	]	-RRB-
cord-017420-tjwxec77	136	37	.	.	.
cord-017420-tjwxec77	137	1	Some	some	DT
cord-017420-tjwxec77	137	2	data	datum	NNS
cord-017420-tjwxec77	137	3	suggest	suggest	VBP
cord-017420-tjwxec77	137	4	improved	improve	VBN
cord-017420-tjwxec77	137	5	outcomes	outcome	NNS
cord-017420-tjwxec77	137	6	with	with	IN
cord-017420-tjwxec77	137	7	prolonged	prolong	VBN
cord-017420-tjwxec77	137	8	antibiotic	antibiotic	JJ
cord-017420-tjwxec77	137	9	infusion	infusion	NN
cord-017420-tjwxec77	137	10	times	time	NNS
cord-017420-tjwxec77	137	11	[	[	-LRB-
cord-017420-tjwxec77	137	12	58	58	CD
cord-017420-tjwxec77	137	13	]	]	-RRB-
cord-017420-tjwxec77	137	14	though	though	IN
cord-017420-tjwxec77	137	15	these	these	DT
cord-017420-tjwxec77	137	16	data	datum	NNS
cord-017420-tjwxec77	137	17	require	require	VBP
cord-017420-tjwxec77	137	18	confirmation	confirmation	NN
cord-017420-tjwxec77	137	19	.	.	.
cord-017420-tjwxec77	138	1	Fluoroquinolones	fluoroquinolone	NNS
cord-017420-tjwxec77	138	2	,	,	,
cord-017420-tjwxec77	138	3	which	which	WDT
cord-017420-tjwxec77	138	4	are	be	VBP
cord-017420-tjwxec77	138	5	frequently	frequently	RB
cord-017420-tjwxec77	138	6	used	use	VBN
cord-017420-tjwxec77	138	7	as	as	IN
cord-017420-tjwxec77	138	8	prophylactic	prophylactic	JJ
cord-017420-tjwxec77	138	9	therapy	therapy	NN
cord-017420-tjwxec77	138	10	in	in	IN
cord-017420-tjwxec77	138	11	neutropenia	neutropenia	NN
cord-017420-tjwxec77	138	12	,	,	,
cord-017420-tjwxec77	138	13	should	should	MD
cord-017420-tjwxec77	138	14	not	not	RB
cord-017420-tjwxec77	138	15	be	be	VB
cord-017420-tjwxec77	138	16	used	use	VBN
cord-017420-tjwxec77	138	17	as	as	IN
cord-017420-tjwxec77	138	18	empiric	empiric	JJ
cord-017420-tjwxec77	138	19	monotherapy	monotherapy	NN
cord-017420-tjwxec77	138	20	in	in	IN
cord-017420-tjwxec77	138	21	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	138	22	fever	fever	NN
cord-017420-tjwxec77	138	23	due	due	IN
cord-017420-tjwxec77	138	24	to	to	IN
cord-017420-tjwxec77	138	25	the	the	DT
cord-017420-tjwxec77	138	26	possibility	possibility	NN
cord-017420-tjwxec77	138	27	of	of	IN
cord-017420-tjwxec77	138	28	resistance	resistance	NN
cord-017420-tjwxec77	138	29	.	.	.
cord-017420-tjwxec77	139	1	Though	though	IN
cord-017420-tjwxec77	139	2	gram	gram	NN
cord-017420-tjwxec77	139	3	-	-	HYPH
cord-017420-tjwxec77	139	4	positive	positive	JJ
cord-017420-tjwxec77	139	5	organisms	organism	NNS
cord-017420-tjwxec77	139	6	are	be	VBP
cord-017420-tjwxec77	139	7	common	common	JJ
cord-017420-tjwxec77	139	8	causes	cause	NNS
cord-017420-tjwxec77	139	9	of	of	IN
cord-017420-tjwxec77	139	10	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	139	11	fever	fever	NN
cord-017420-tjwxec77	139	12	,	,	,
cord-017420-tjwxec77	139	13	vancomycin	vancomycin	NN
cord-017420-tjwxec77	139	14	is	be	VBZ
cord-017420-tjwxec77	139	15	not	not	RB
cord-017420-tjwxec77	139	16	routinely	routinely	RB
cord-017420-tjwxec77	139	17	indicated	indicate	VBN
cord-017420-tjwxec77	139	18	,	,	,
cord-017420-tjwxec77	139	19	but	but	CC
cord-017420-tjwxec77	139	20	should	should	MD
cord-017420-tjwxec77	139	21	be	be	VB
cord-017420-tjwxec77	139	22	added	add	VBN
cord-017420-tjwxec77	139	23	in	in	IN
cord-017420-tjwxec77	139	24	the	the	DT
cord-017420-tjwxec77	139	25	presence	presence	NN
cord-017420-tjwxec77	139	26	of	of	IN
cord-017420-tjwxec77	139	27	suspected	suspect	VBN
cord-017420-tjwxec77	139	28	catheter	catheter	NN
cord-017420-tjwxec77	139	29	-	-	HYPH
cord-017420-tjwxec77	139	30	related	relate	VBN
cord-017420-tjwxec77	139	31	infection	infection	NN
cord-017420-tjwxec77	139	32	,	,	,
cord-017420-tjwxec77	139	33	soft	soft	JJ
cord-017420-tjwxec77	139	34	tissue	tissue	NN
cord-017420-tjwxec77	139	35	infection	infection	NN
cord-017420-tjwxec77	139	36	,	,	,
cord-017420-tjwxec77	139	37	oral	oral	JJ
cord-017420-tjwxec77	139	38	mucositis	mucositis	NNP
cord-017420-tjwxec77	139	39	,	,	,
cord-017420-tjwxec77	139	40	radiographically	radiographically	RB
cord-017420-tjwxec77	139	41	proven	prove	VBN
cord-017420-tjwxec77	139	42	pneumonia	pneumonia	NN
cord-017420-tjwxec77	139	43	,	,	,
cord-017420-tjwxec77	139	44	known	know	VBN
cord-017420-tjwxec77	139	45	colonization	colonization	NN
cord-017420-tjwxec77	139	46	with	with	IN
cord-017420-tjwxec77	139	47	resistant	resistant	JJ
cord-017420-tjwxec77	139	48	gram	gram	NN
cord-017420-tjwxec77	139	49	-	-	HYPH
cord-017420-tjwxec77	139	50	positive	positive	JJ
cord-017420-tjwxec77	139	51	organisms	organism	NNS
cord-017420-tjwxec77	139	52	(	(	-LRB-
cord-017420-tjwxec77	139	53	e.g.	e.g.	RB
cord-017420-tjwxec77	139	54	,	,	,
cord-017420-tjwxec77	139	55	methicillin	methicillin	NN
cord-017420-tjwxec77	139	56	-	-	HYPH
cord-017420-tjwxec77	139	57	resistant	resistant	JJ
cord-017420-tjwxec77	139	58	Staphylococcus	Staphylococcus	NNP
cord-017420-tjwxec77	139	59	aureus	aureus	NN
cord-017420-tjwxec77	139	60	,	,	,
cord-017420-tjwxec77	139	61	penicillin	penicillin	NN
cord-017420-tjwxec77	139	62	-	-	HYPH
cord-017420-tjwxec77	139	63	resistant	resistant	JJ
cord-017420-tjwxec77	139	64	Streptococcus	Streptococcus	NNP
cord-017420-tjwxec77	139	65	)	)	-RRB-
cord-017420-tjwxec77	139	66	,	,	,
cord-017420-tjwxec77	139	67	or	or	CC
cord-017420-tjwxec77	139	68	hemodynamic	hemodynamic	JJ
cord-017420-tjwxec77	139	69	instability	instability	NN
cord-017420-tjwxec77	139	70	[	[	-LRB-
cord-017420-tjwxec77	139	71	28	28	CD
cord-017420-tjwxec77	139	72	,	,	,
cord-017420-tjwxec77	139	73	33	33	CD
cord-017420-tjwxec77	139	74	,	,	,
cord-017420-tjwxec77	139	75	57	57	CD
cord-017420-tjwxec77	139	76	]	]	-RRB-
cord-017420-tjwxec77	139	77	.	.	.
cord-017420-tjwxec77	140	1	The	the	DT
cord-017420-tjwxec77	140	2	use	use	NN
cord-017420-tjwxec77	140	3	of	of	IN
cord-017420-tjwxec77	140	4	combination	combination	NN
cord-017420-tjwxec77	140	5	antibiotic	antibiotic	JJ
cord-017420-tjwxec77	140	6	regimens	regimen	NNS
cord-017420-tjwxec77	140	7	(	(	-LRB-
cord-017420-tjwxec77	140	8	defined	define	VBN
cord-017420-tjwxec77	140	9	as	as	IN
cord-017420-tjwxec77	140	10	dual	dual	JJ
cord-017420-tjwxec77	140	11	gram	gram	NN
cord-017420-tjwxec77	140	12	-	-	HYPH
cord-017420-tjwxec77	140	13	negative	negative	JJ
cord-017420-tjwxec77	140	14	coverage	coverage	NN
cord-017420-tjwxec77	140	15	with	with	IN
cord-017420-tjwxec77	140	16	an	an	DT
cord-017420-tjwxec77	140	17	antipseudomonal	antipseudomonal	JJ
cord-017420-tjwxec77	140	18	beta	beta	NN
cord-017420-tjwxec77	140	19	-	-	HYPH
cord-017420-tjwxec77	140	20	lactam	lactam	NNS
cord-017420-tjwxec77	140	21	and	and	CC
cord-017420-tjwxec77	140	22	an	an	DT
cord-017420-tjwxec77	140	23	aminoglycoside	aminoglycoside	NN
cord-017420-tjwxec77	140	24	)	)	-RRB-
cord-017420-tjwxec77	140	25	in	in	IN
cord-017420-tjwxec77	140	26	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	140	27	fever	fever	NN
cord-017420-tjwxec77	140	28	is	be	VBZ
cord-017420-tjwxec77	140	29	controversial	controversial	JJ
cord-017420-tjwxec77	140	30	.	.	.
cord-017420-tjwxec77	141	1	Though	though	IN
cord-017420-tjwxec77	141	2	some	some	DT
cord-017420-tjwxec77	141	3	studies	study	NNS
cord-017420-tjwxec77	141	4	have	have	VBP
cord-017420-tjwxec77	141	5	suggested	suggest	VBN
cord-017420-tjwxec77	141	6	a	a	DT
cord-017420-tjwxec77	141	7	mortality	mortality	NN
cord-017420-tjwxec77	141	8	benefit	benefit	NN
cord-017420-tjwxec77	141	9	to	to	IN
cord-017420-tjwxec77	141	10	combination	combination	NN
cord-017420-tjwxec77	141	11	antibiotics	antibiotic	NNS
cord-017420-tjwxec77	141	12	[	[	-LRB-
cord-017420-tjwxec77	141	13	39	39	CD
cord-017420-tjwxec77	141	14	]	]	-RRB-
cord-017420-tjwxec77	141	15	,	,	,
cord-017420-tjwxec77	141	16	this	this	DT
cord-017420-tjwxec77	141	17	has	have	VBZ
cord-017420-tjwxec77	141	18	not	not	RB
cord-017420-tjwxec77	141	19	been	be	VBN
cord-017420-tjwxec77	141	20	a	a	DT
cord-017420-tjwxec77	141	21	consistent	consistent	JJ
cord-017420-tjwxec77	141	22	finding	finding	NN
cord-017420-tjwxec77	141	23	,	,	,
cord-017420-tjwxec77	141	24	and	and	CC
cord-017420-tjwxec77	141	25	2	2	CD
cord-017420-tjwxec77	141	26	metaanalyses	metaanalyse	NNS
cord-017420-tjwxec77	141	27	have	have	VBP
cord-017420-tjwxec77	141	28	shown	show	VBN
cord-017420-tjwxec77	141	29	no	no	DT
cord-017420-tjwxec77	141	30	benefit	benefit	NN
cord-017420-tjwxec77	141	31	to	to	IN
cord-017420-tjwxec77	141	32	the	the	DT
cord-017420-tjwxec77	141	33	addition	addition	NN
cord-017420-tjwxec77	141	34	of	of	IN
cord-017420-tjwxec77	141	35	an	an	DT
cord-017420-tjwxec77	141	36	aminoglycoside	aminoglycoside	NN
cord-017420-tjwxec77	141	37	to	to	IN
cord-017420-tjwxec77	141	38	a	a	DT
cord-017420-tjwxec77	141	39	beta	beta	NN
cord-017420-tjwxec77	141	40	-	-	HYPH
cord-017420-tjwxec77	141	41	lactam	lactam	NNS
cord-017420-tjwxec77	141	42	and	and	CC
cord-017420-tjwxec77	141	43	a	a	DT
cord-017420-tjwxec77	141	44	higher	high	JJR
cord-017420-tjwxec77	141	45	risk	risk	NN
cord-017420-tjwxec77	141	46	of	of	IN
cord-017420-tjwxec77	141	47	renal	renal	JJ
cord-017420-tjwxec77	141	48	failure	failure	NN
cord-017420-tjwxec77	141	49	with	with	IN
cord-017420-tjwxec77	141	50	combination	combination	NN
cord-017420-tjwxec77	141	51	therapy	therapy	NN
cord-017420-tjwxec77	141	52	[	[	-LRB-
cord-017420-tjwxec77	141	53	55	55	CD
cord-017420-tjwxec77	141	54	,	,	,
cord-017420-tjwxec77	141	55	56	56	CD
cord-017420-tjwxec77	141	56	]	]	-RRB-
cord-017420-tjwxec77	141	57	.	.	.
cord-017420-tjwxec77	142	1	Accordingly	accordingly	RB
cord-017420-tjwxec77	142	2	,	,	,
cord-017420-tjwxec77	142	3	current	current	JJ
cord-017420-tjwxec77	142	4	guidelines	guideline	NNS
cord-017420-tjwxec77	142	5	for	for	IN
cord-017420-tjwxec77	142	6	the	the	DT
cord-017420-tjwxec77	142	7	management	management	NN
cord-017420-tjwxec77	142	8	of	of	IN
cord-017420-tjwxec77	142	9	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	142	10	fever	fever	NN
cord-017420-tjwxec77	142	11	and	and	CC
cord-017420-tjwxec77	142	12	sepsis	sepsis	NN
cord-017420-tjwxec77	142	13	recommend	recommend	VBP
cord-017420-tjwxec77	142	14	monotherapy	monotherapy	NN
cord-017420-tjwxec77	142	15	with	with	IN
cord-017420-tjwxec77	142	16	an	an	DT
cord-017420-tjwxec77	142	17	antipseudomonal	antipseudomonal	JJ
cord-017420-tjwxec77	142	18	beta	beta	NN
cord-017420-tjwxec77	142	19	-	-	HYPH
cord-017420-tjwxec77	142	20	lactam	lactam	NNS
cord-017420-tjwxec77	142	21	unless	unless	IN
cord-017420-tjwxec77	142	22	otherwise	otherwise	RB
cord-017420-tjwxec77	142	23	dictated	dictate	VBN
cord-017420-tjwxec77	142	24	by	by	IN
cord-017420-tjwxec77	142	25	circumstances	circumstance	NNS
cord-017420-tjwxec77	142	26	such	such	JJ
cord-017420-tjwxec77	142	27	as	as	IN
cord-017420-tjwxec77	142	28	patient	patient	JJ
cord-017420-tjwxec77	142	29	allergies	allergy	NNS
cord-017420-tjwxec77	142	30	,	,	,
cord-017420-tjwxec77	142	31	the	the	DT
cord-017420-tjwxec77	142	32	presence	presence	NN
cord-017420-tjwxec77	142	33	of	of	IN
cord-017420-tjwxec77	142	34	resistant	resistant	JJ
cord-017420-tjwxec77	142	35	organisms	organism	NNS
cord-017420-tjwxec77	142	36	,	,	,
cord-017420-tjwxec77	142	37	or	or	CC
cord-017420-tjwxec77	142	38	refractory	refractory	JJ
cord-017420-tjwxec77	142	39	hemodynamic	hemodynamic	JJ
cord-017420-tjwxec77	142	40	instability	instability	NN
cord-017420-tjwxec77	142	41	[	[	-LRB-
cord-017420-tjwxec77	142	42	28	28	CD
cord-017420-tjwxec77	142	43	,	,	,
cord-017420-tjwxec77	142	44	57	57	CD
cord-017420-tjwxec77	142	45	,	,	,
cord-017420-tjwxec77	142	46	61	61	CD
cord-017420-tjwxec77	142	47	]	]	-RRB-
cord-017420-tjwxec77	142	48	.	.	.
cord-017420-tjwxec77	143	1	It	-PRON-	PRP
cord-017420-tjwxec77	143	2	should	should	MD
cord-017420-tjwxec77	143	3	be	be	VB
cord-017420-tjwxec77	143	4	noted	note	VBN
cord-017420-tjwxec77	143	5	,	,	,
cord-017420-tjwxec77	143	6	however	however	RB
cord-017420-tjwxec77	143	7	,	,	,
cord-017420-tjwxec77	143	8	that	that	IN
cord-017420-tjwxec77	143	9	this	this	DT
cord-017420-tjwxec77	143	10	recommendation	recommendation	NN
cord-017420-tjwxec77	143	11	does	do	VBZ
cord-017420-tjwxec77	143	12	not	not	RB
cord-017420-tjwxec77	143	13	preclude	preclude	VB
cord-017420-tjwxec77	143	14	the	the	DT
cord-017420-tjwxec77	143	15	use	use	NN
cord-017420-tjwxec77	143	16	of	of	IN
cord-017420-tjwxec77	143	17	vancomycin	vancomycin	NNS
cord-017420-tjwxec77	143	18	or	or	CC
cord-017420-tjwxec77	143	19	antifungals	antifungal	NNS
cord-017420-tjwxec77	143	20	;	;	:
cord-017420-tjwxec77	143	21	it	-PRON-	PRP
cord-017420-tjwxec77	143	22	is	be	VBZ
cord-017420-tjwxec77	143	23	only	only	RB
cord-017420-tjwxec77	143	24	directed	direct	VBN
cord-017420-tjwxec77	143	25	at	at	IN
cord-017420-tjwxec77	143	26	combination	combination	NN
cord-017420-tjwxec77	143	27	therapy	therapy	NN
cord-017420-tjwxec77	143	28	targeted	target	VBN
cord-017420-tjwxec77	143	29	against	against	IN
cord-017420-tjwxec77	143	30	gram	gram	NN
cord-017420-tjwxec77	143	31	-	-	HYPH
cord-017420-tjwxec77	143	32	negative	negative	JJ
cord-017420-tjwxec77	143	33	bacteria	bacteria	NNS
cord-017420-tjwxec77	143	34	.	.	.
cord-017420-tjwxec77	144	1	Even	even	RB
cord-017420-tjwxec77	144	2	with	with	IN
cord-017420-tjwxec77	144	3	appropriate	appropriate	JJ
cord-017420-tjwxec77	144	4	antibiotics	antibiotic	NNS
cord-017420-tjwxec77	144	5	,	,	,
cord-017420-tjwxec77	144	6	fever	fever	NN
cord-017420-tjwxec77	144	7	in	in	IN
cord-017420-tjwxec77	144	8	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	144	9	patients	patient	NNS
cord-017420-tjwxec77	144	10	typically	typically	RB
cord-017420-tjwxec77	144	11	persists	persist	VBZ
cord-017420-tjwxec77	144	12	for	for	IN
cord-017420-tjwxec77	144	13	a	a	DT
cord-017420-tjwxec77	144	14	median	median	NN
cord-017420-tjwxec77	144	15	of	of	IN
cord-017420-tjwxec77	144	16	5	5	CD
cord-017420-tjwxec77	144	17	days	day	NNS
cord-017420-tjwxec77	144	18	;	;	:
cord-017420-tjwxec77	144	19	thus	thus	RB
cord-017420-tjwxec77	144	20	,	,	,
cord-017420-tjwxec77	144	21	ongoing	ongoing	JJ
cord-017420-tjwxec77	144	22	fevers	fever	NNS
cord-017420-tjwxec77	144	23	,	,	,
cord-017420-tjwxec77	144	24	unless	unless	IN
cord-017420-tjwxec77	144	25	accompanied	accompany	VBN
cord-017420-tjwxec77	144	26	by	by	IN
cord-017420-tjwxec77	144	27	clinical	clinical	JJ
cord-017420-tjwxec77	144	28	instability	instability	NN
cord-017420-tjwxec77	144	29	,	,	,
cord-017420-tjwxec77	144	30	should	should	MD
cord-017420-tjwxec77	144	31	not	not	RB
cord-017420-tjwxec77	144	32	necessarily	necessarily	RB
cord-017420-tjwxec77	144	33	be	be	VB
cord-017420-tjwxec77	144	34	viewed	view	VBN
cord-017420-tjwxec77	144	35	as	as	IN
cord-017420-tjwxec77	144	36	evidence	evidence	NN
cord-017420-tjwxec77	144	37	of	of	IN
cord-017420-tjwxec77	144	38	failure	failure	NN
cord-017420-tjwxec77	144	39	of	of	IN
cord-017420-tjwxec77	144	40	antibiotic	antibiotic	JJ
cord-017420-tjwxec77	144	41	therapy	therapy	NN
cord-017420-tjwxec77	144	42	[	[	-LRB-
cord-017420-tjwxec77	144	43	73	73	CD
cord-017420-tjwxec77	144	44	]	]	-RRB-
cord-017420-tjwxec77	144	45	.	.	.
cord-017420-tjwxec77	145	1	In	in	IN
cord-017420-tjwxec77	145	2	patients	patient	NNS
cord-017420-tjwxec77	145	3	with	with	IN
cord-017420-tjwxec77	145	4	persistent	persistent	JJ
cord-017420-tjwxec77	145	5	or	or	CC
cord-017420-tjwxec77	145	6	recurrent	recurrent	JJ
cord-017420-tjwxec77	145	7	fevers	fever	NNS
cord-017420-tjwxec77	145	8	after	after	IN
cord-017420-tjwxec77	145	9	3	3	CD
cord-017420-tjwxec77	145	10	-	-	SYM
cord-017420-tjwxec77	145	11	5	5	CD
cord-017420-tjwxec77	145	12	days	day	NNS
cord-017420-tjwxec77	145	13	,	,	,
cord-017420-tjwxec77	145	14	a	a	DT
cord-017420-tjwxec77	145	15	modification	modification	NN
cord-017420-tjwxec77	145	16	of	of	IN
cord-017420-tjwxec77	145	17	antibiotic	antibiotic	JJ
cord-017420-tjwxec77	145	18	regimen	regimen	NN
cord-017420-tjwxec77	145	19	is	be	VBZ
cord-017420-tjwxec77	145	20	reasonable	reasonable	JJ
cord-017420-tjwxec77	145	21	,	,	,
cord-017420-tjwxec77	145	22	especially	especially	RB
cord-017420-tjwxec77	145	23	if	if	IN
cord-017420-tjwxec77	145	24	guided	guide	VBN
cord-017420-tjwxec77	145	25	by	by	IN
cord-017420-tjwxec77	145	26	new	new	JJ
cord-017420-tjwxec77	145	27	or	or	CC
cord-017420-tjwxec77	145	28	changing	change	VBG
cord-017420-tjwxec77	145	29	clinical	clinical	JJ
cord-017420-tjwxec77	145	30	data	datum	NNS
cord-017420-tjwxec77	145	31	.	.	.
cord-017420-tjwxec77	146	1	Earlier	early	JJR
cord-017420-tjwxec77	146	2	antibiotic	antibiotic	JJ
cord-017420-tjwxec77	146	3	escalation	escalation	NN
cord-017420-tjwxec77	146	4	is	be	VBZ
cord-017420-tjwxec77	146	5	necessary	necessary	JJ
cord-017420-tjwxec77	146	6	in	in	IN
cord-017420-tjwxec77	146	7	some	some	DT
cord-017420-tjwxec77	146	8	patients	patient	NNS
cord-017420-tjwxec77	146	9	,	,	,
cord-017420-tjwxec77	146	10	most	most	RBS
cord-017420-tjwxec77	146	11	commonly	commonly	RB
cord-017420-tjwxec77	146	12	in	in	IN
cord-017420-tjwxec77	146	13	patients	patient	NNS
cord-017420-tjwxec77	146	14	with	with	IN
cord-017420-tjwxec77	146	15	hemodynamic	hemodynamic	JJ
cord-017420-tjwxec77	146	16	instability	instability	NN
cord-017420-tjwxec77	146	17	.	.	.
cord-017420-tjwxec77	147	1	In	in	IN
cord-017420-tjwxec77	147	2	the	the	DT
cord-017420-tjwxec77	147	3	face	face	NN
cord-017420-tjwxec77	147	4	of	of	IN
cord-017420-tjwxec77	147	5	hemodynamic	hemodynamic	JJ
cord-017420-tjwxec77	147	6	instability	instability	NN
cord-017420-tjwxec77	147	7	,	,	,
cord-017420-tjwxec77	147	8	vancomycin	vancomycin	NN
cord-017420-tjwxec77	147	9	should	should	MD
cord-017420-tjwxec77	147	10	be	be	VB
cord-017420-tjwxec77	147	11	added	add	VBN
cord-017420-tjwxec77	147	12	if	if	IN
cord-017420-tjwxec77	147	13	not	not	RB
cord-017420-tjwxec77	147	14	already	already	RB
cord-017420-tjwxec77	147	15	part	part	NN
cord-017420-tjwxec77	147	16	of	of	IN
cord-017420-tjwxec77	147	17	the	the	DT
cord-017420-tjwxec77	147	18	regimen	regimen	NN
cord-017420-tjwxec77	147	19	.	.	.
cord-017420-tjwxec77	148	1	Additionally	additionally	RB
cord-017420-tjwxec77	148	2	,	,	,
cord-017420-tjwxec77	148	3	antipseudomonal	antipseudomonal	JJ
cord-017420-tjwxec77	148	4	cephalosporins	cephalosporin	NNS
cord-017420-tjwxec77	148	5	or	or	CC
cord-017420-tjwxec77	148	6	penicillins	penicillin	NNS
cord-017420-tjwxec77	148	7	should	should	MD
cord-017420-tjwxec77	148	8	be	be	VB
cord-017420-tjwxec77	148	9	escalated	escalate	VBN
cord-017420-tjwxec77	148	10	to	to	IN
cord-017420-tjwxec77	148	11	a	a	DT
cord-017420-tjwxec77	148	12	carbapenem	carbapenem	NN
cord-017420-tjwxec77	148	13	(	(	-LRB-
cord-017420-tjwxec77	148	14	e.g.	e.g.	RB
cord-017420-tjwxec77	148	15	,	,	,
cord-017420-tjwxec77	148	16	meropenem	meropenem	NNP
cord-017420-tjwxec77	148	17	)	)	-RRB-
cord-017420-tjwxec77	148	18	,	,	,
cord-017420-tjwxec77	148	19	and	and	CC
cord-017420-tjwxec77	148	20	strong	strong	JJ
cord-017420-tjwxec77	148	21	consideration	consideration	NN
cord-017420-tjwxec77	148	22	should	should	MD
cord-017420-tjwxec77	148	23	be	be	VB
cord-017420-tjwxec77	148	24	given	give	VBN
cord-017420-tjwxec77	148	25	to	to	IN
cord-017420-tjwxec77	148	26	the	the	DT
cord-017420-tjwxec77	148	27	addition	addition	NN
cord-017420-tjwxec77	148	28	of	of	IN
cord-017420-tjwxec77	148	29	an	an	DT
cord-017420-tjwxec77	148	30	aminoglycoside	aminoglycoside	NN
cord-017420-tjwxec77	148	31	,	,	,
cord-017420-tjwxec77	148	32	fluoroquinolone	fluoroquinolone	NN
cord-017420-tjwxec77	148	33	,	,	,
cord-017420-tjwxec77	148	34	or	or	CC
cord-017420-tjwxec77	148	35	aztreonam	aztreonam	NNP
cord-017420-tjwxec77	148	36	[	[	-LRB-
cord-017420-tjwxec77	148	37	28	28	CD
cord-017420-tjwxec77	148	38	,	,	,
cord-017420-tjwxec77	148	39	33	33	CD
cord-017420-tjwxec77	148	40	,	,	,
cord-017420-tjwxec77	148	41	57	57	CD
cord-017420-tjwxec77	148	42	,	,	,
cord-017420-tjwxec77	148	43	61	61	CD
cord-017420-tjwxec77	148	44	]	]	-RRB-
cord-017420-tjwxec77	148	45	.	.	.
cord-017420-tjwxec77	149	1	Drug	drug	NN
cord-017420-tjwxec77	149	2	-	-	HYPH
cord-017420-tjwxec77	149	3	resistant	resistant	JJ
cord-017420-tjwxec77	149	4	and	and	CC
cord-017420-tjwxec77	149	5	multidrug	multidrug	NN
cord-017420-tjwxec77	149	6	-	-	HYPH
cord-017420-tjwxec77	149	7	resistant	resistant	JJ
cord-017420-tjwxec77	149	8	(	(	-LRB-
cord-017420-tjwxec77	149	9	MDR	MDR	NNP
cord-017420-tjwxec77	149	10	)	)	-RRB-
cord-017420-tjwxec77	149	11	organisms	organism	NNS
cord-017420-tjwxec77	149	12	are	be	VBP
cord-017420-tjwxec77	149	13	an	an	DT
cord-017420-tjwxec77	149	14	increasing	increase	VBG
cord-017420-tjwxec77	149	15	problem	problem	NN
cord-017420-tjwxec77	149	16	in	in	IN
cord-017420-tjwxec77	149	17	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	149	18	infections	infection	NNS
cord-017420-tjwxec77	149	19	[	[	-LRB-
cord-017420-tjwxec77	149	20	26	26	CD
cord-017420-tjwxec77	149	21	,	,	,
cord-017420-tjwxec77	149	22	29	29	CD
cord-017420-tjwxec77	149	23	,	,	,
cord-017420-tjwxec77	149	24	50	50	CD
cord-017420-tjwxec77	149	25	]	]	-RRB-
cord-017420-tjwxec77	149	26	.	.	.
cord-017420-tjwxec77	150	1	Vancomycin	vancomycin	NN
cord-017420-tjwxec77	150	2	-	-	HYPH
cord-017420-tjwxec77	150	3	resistant	resistant	JJ
cord-017420-tjwxec77	150	4	enterococcus	enterococcus	NN
cord-017420-tjwxec77	150	5	(	(	-LRB-
cord-017420-tjwxec77	150	6	VRE	VRE	NNP
cord-017420-tjwxec77	150	7	)	)	-RRB-
cord-017420-tjwxec77	150	8	bacteremia	bacteremia	NN
cord-017420-tjwxec77	150	9	affects	affect	VBZ
cord-017420-tjwxec77	150	10	a	a	DT
cord-017420-tjwxec77	150	11	substantial	substantial	JJ
cord-017420-tjwxec77	150	12	portion	portion	NN
cord-017420-tjwxec77	150	13	(	(	-LRB-
cord-017420-tjwxec77	150	14	10	10	CD
cord-017420-tjwxec77	150	15	-	-	SYM
cord-017420-tjwxec77	150	16	35	35	CD
cord-017420-tjwxec77	150	17	%	%	NN
cord-017420-tjwxec77	150	18	)	)	-RRB-
cord-017420-tjwxec77	150	19	of	of	IN
cord-017420-tjwxec77	150	20	patients	patient	NNS
cord-017420-tjwxec77	150	21	during	during	IN
cord-017420-tjwxec77	150	22	induction	induction	NN
cord-017420-tjwxec77	150	23	therapy	therapy	NN
cord-017420-tjwxec77	150	24	for	for	IN
cord-017420-tjwxec77	150	25	leukemia	leukemia	NN
cord-017420-tjwxec77	150	26	or	or	CC
cord-017420-tjwxec77	150	27	after	after	IN
cord-017420-tjwxec77	150	28	HSCT	HSCT	NNP
cord-017420-tjwxec77	150	29	and	and	CC
cord-017420-tjwxec77	150	30	is	be	VBZ
cord-017420-tjwxec77	150	31	associated	associate	VBN
cord-017420-tjwxec77	150	32	with	with	IN
cord-017420-tjwxec77	150	33	significantly	significantly	RB
cord-017420-tjwxec77	150	34	worse	bad	JJR
cord-017420-tjwxec77	150	35	outcomes	outcome	NNS
cord-017420-tjwxec77	150	36	[	[	-LRB-
cord-017420-tjwxec77	150	37	3	3	CD
cord-017420-tjwxec77	150	38	,	,	,
cord-017420-tjwxec77	150	39	53	53	CD
cord-017420-tjwxec77	150	40	,	,	,
cord-017420-tjwxec77	150	41	85	85	CD
cord-017420-tjwxec77	150	42	]	]	-RRB-
cord-017420-tjwxec77	150	43	.	.	.
cord-017420-tjwxec77	151	1	Early	early	JJ
cord-017420-tjwxec77	151	2	treatment	treatment	NN
cord-017420-tjwxec77	151	3	with	with	IN
cord-017420-tjwxec77	151	4	agents	agent	NNS
cord-017420-tjwxec77	151	5	active	active	JJ
cord-017420-tjwxec77	151	6	against	against	IN
cord-017420-tjwxec77	151	7	VRE	VRE	NNP
cord-017420-tjwxec77	151	8	such	such	JJ
cord-017420-tjwxec77	151	9	as	as	IN
cord-017420-tjwxec77	151	10	linezolid	linezolid	NNP
cord-017420-tjwxec77	151	11	or	or	CC
cord-017420-tjwxec77	151	12	daptomycin	daptomycin	NNS
cord-017420-tjwxec77	151	13	may	may	MD
cord-017420-tjwxec77	151	14	improve	improve	VB
cord-017420-tjwxec77	151	15	outcomes	outcome	NNS
cord-017420-tjwxec77	151	16	.	.	.
cord-017420-tjwxec77	152	1	Predictive	predictive	JJ
cord-017420-tjwxec77	152	2	models	model	NNS
cord-017420-tjwxec77	152	3	are	be	VBP
cord-017420-tjwxec77	152	4	being	be	VBG
cord-017420-tjwxec77	152	5	developed	develop	VBN
cord-017420-tjwxec77	152	6	to	to	TO
cord-017420-tjwxec77	152	7	assist	assist	VB
cord-017420-tjwxec77	152	8	with	with	IN
cord-017420-tjwxec77	152	9	early	early	JJ
cord-017420-tjwxec77	152	10	identification	identification	NN
cord-017420-tjwxec77	152	11	of	of	IN
cord-017420-tjwxec77	152	12	patients	patient	NNS
cord-017420-tjwxec77	152	13	who	who	WP
cord-017420-tjwxec77	152	14	might	may	MD
cord-017420-tjwxec77	152	15	benefit	benefit	VB
cord-017420-tjwxec77	152	16	from	from	IN
cord-017420-tjwxec77	152	17	early	early	JJ
cord-017420-tjwxec77	152	18	initiation	initiation	NN
cord-017420-tjwxec77	152	19	of	of	IN
cord-017420-tjwxec77	152	20	antibiotics	antibiotic	NNS
cord-017420-tjwxec77	152	21	active	active	JJ
cord-017420-tjwxec77	152	22	against	against	IN
cord-017420-tjwxec77	152	23	VRE	VRE	NNP
cord-017420-tjwxec77	152	24	[	[	-LRB-
cord-017420-tjwxec77	152	25	83	83	CD
cord-017420-tjwxec77	152	26	]	]	-RRB-
cord-017420-tjwxec77	152	27	.	.	.
cord-017420-tjwxec77	153	1	Similarly	similarly	RB
cord-017420-tjwxec77	153	2	,	,	,
cord-017420-tjwxec77	153	3	MDR	MDR	NNP
cord-017420-tjwxec77	153	4	gram	gram	NN
cord-017420-tjwxec77	153	5	-	-	HYPH
cord-017420-tjwxec77	153	6	negative	negative	JJ
cord-017420-tjwxec77	153	7	infections	infection	NNS
cord-017420-tjwxec77	153	8	,	,	,
cord-017420-tjwxec77	153	9	particularly	particularly	RB
cord-017420-tjwxec77	153	10	carbapenem	carbapenem	NN
cord-017420-tjwxec77	153	11	-	-	HYPH
cord-017420-tjwxec77	153	12	resistant	resistant	JJ
cord-017420-tjwxec77	153	13	Enterobacteriaceae	Enterobacteriaceae	NNP
cord-017420-tjwxec77	153	14	,	,	,
cord-017420-tjwxec77	153	15	are	be	VBP
cord-017420-tjwxec77	153	16	associated	associate	VBN
cord-017420-tjwxec77	153	17	with	with	IN
cord-017420-tjwxec77	153	18	high	high	JJ
cord-017420-tjwxec77	153	19	mortality	mortality	NN
cord-017420-tjwxec77	153	20	rates	rate	NNS
cord-017420-tjwxec77	153	21	,	,	,
cord-017420-tjwxec77	153	22	especially	especially	RB
cord-017420-tjwxec77	153	23	among	among	IN
cord-017420-tjwxec77	153	24	allogeneic	allogeneic	IN
cord-017420-tjwxec77	153	25	HSCT	HSCT	NNP
cord-017420-tjwxec77	153	26	patients	patient	NNS
cord-017420-tjwxec77	153	27	[	[	-LRB-
cord-017420-tjwxec77	153	28	66	66	CD
cord-017420-tjwxec77	153	29	]	]	-RRB-
cord-017420-tjwxec77	153	30	.	.	.
cord-017420-tjwxec77	154	1	Successful	successful	JJ
cord-017420-tjwxec77	154	2	treatment	treatment	NN
cord-017420-tjwxec77	154	3	of	of	IN
cord-017420-tjwxec77	154	4	these	these	DT
cord-017420-tjwxec77	154	5	infections	infection	NNS
cord-017420-tjwxec77	154	6	requires	require	VBZ
cord-017420-tjwxec77	154	7	early	early	JJ
cord-017420-tjwxec77	154	8	use	use	NN
cord-017420-tjwxec77	154	9	of	of	IN
cord-017420-tjwxec77	154	10	multidrug	multidrug	NN
cord-017420-tjwxec77	154	11	antibiotic	antibiotic	JJ
cord-017420-tjwxec77	154	12	regimens	regimen	NNS
cord-017420-tjwxec77	154	13	,	,	,
cord-017420-tjwxec77	154	14	typically	typically	RB
cord-017420-tjwxec77	154	15	including	include	VBG
cord-017420-tjwxec77	154	16	aminoglycosides	aminoglycoside	NNS
cord-017420-tjwxec77	154	17	,	,	,
cord-017420-tjwxec77	154	18	carbapenems	carbapenem	NNS
cord-017420-tjwxec77	154	19	,	,	,
cord-017420-tjwxec77	154	20	and	and	CC
cord-017420-tjwxec77	154	21	polymyxins	polymyxin	NNS
cord-017420-tjwxec77	154	22	.	.	.
cord-017420-tjwxec77	155	1	The	the	DT
cord-017420-tjwxec77	155	2	use	use	NN
cord-017420-tjwxec77	155	3	of	of	IN
cord-017420-tjwxec77	155	4	surveillance	surveillance	NN
cord-017420-tjwxec77	155	5	rectal	rectal	JJ
cord-017420-tjwxec77	155	6	cultures	culture	NNS
cord-017420-tjwxec77	155	7	,	,	,
cord-017420-tjwxec77	155	8	performed	perform	VBN
cord-017420-tjwxec77	155	9	pre	pre	NN
cord-017420-tjwxec77	155	10	-	-	NN
cord-017420-tjwxec77	155	11	transplant	transplant	NN
cord-017420-tjwxec77	155	12	and	and	CC
cord-017420-tjwxec77	155	13	then	then	RB
cord-017420-tjwxec77	155	14	weekly	weekly	RB
cord-017420-tjwxec77	155	15	after	after	IN
cord-017420-tjwxec77	155	16	HSCT	HSCT	NNP
cord-017420-tjwxec77	155	17	,	,	,
cord-017420-tjwxec77	155	18	to	to	TO
cord-017420-tjwxec77	155	19	identify	identify	VB
cord-017420-tjwxec77	155	20	patients	patient	NNS
cord-017420-tjwxec77	155	21	with	with	IN
cord-017420-tjwxec77	155	22	MDR	MDR	NNP
cord-017420-tjwxec77	155	23	infections	infection	NNS
cord-017420-tjwxec77	155	24	and	and	CC
cord-017420-tjwxec77	155	25	allow	allow	VB
cord-017420-tjwxec77	155	26	immediate	immediate	JJ
cord-017420-tjwxec77	155	27	initiation	initiation	NN
cord-017420-tjwxec77	155	28	of	of	IN
cord-017420-tjwxec77	155	29	antibiotic	antibiotic	JJ
cord-017420-tjwxec77	155	30	therapy	therapy	NN
cord-017420-tjwxec77	155	31	targeted	target	VBN
cord-017420-tjwxec77	155	32	against	against	IN
cord-017420-tjwxec77	155	33	MDR	MDR	NNP
cord-017420-tjwxec77	155	34	organisms	organism	NNS
cord-017420-tjwxec77	155	35	may	may	MD
cord-017420-tjwxec77	155	36	result	result	VB
cord-017420-tjwxec77	155	37	in	in	IN
cord-017420-tjwxec77	155	38	better	well	JJR
cord-017420-tjwxec77	155	39	outcomes	outcome	NNS
cord-017420-tjwxec77	155	40	[	[	-LRB-
cord-017420-tjwxec77	155	41	26	26	CD
cord-017420-tjwxec77	155	42	]	]	-RRB-
cord-017420-tjwxec77	155	43	.	.	.
cord-017420-tjwxec77	156	1	Fungal	fungal	JJ
cord-017420-tjwxec77	156	2	pathogens	pathogen	NNS
cord-017420-tjwxec77	156	3	are	be	VBP
cord-017420-tjwxec77	156	4	a	a	DT
cord-017420-tjwxec77	156	5	constant	constant	JJ
cord-017420-tjwxec77	156	6	threat	threat	NN
cord-017420-tjwxec77	156	7	in	in	IN
cord-017420-tjwxec77	156	8	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	156	9	patients	patient	NNS
cord-017420-tjwxec77	156	10	,	,	,
cord-017420-tjwxec77	156	11	and	and	CC
cord-017420-tjwxec77	156	12	consideration	consideration	NN
cord-017420-tjwxec77	156	13	must	must	MD
cord-017420-tjwxec77	156	14	be	be	VB
cord-017420-tjwxec77	156	15	given	give	VBN
cord-017420-tjwxec77	156	16	to	to	IN
cord-017420-tjwxec77	156	17	the	the	DT
cord-017420-tjwxec77	156	18	use	use	NN
cord-017420-tjwxec77	156	19	of	of	IN
cord-017420-tjwxec77	156	20	antifungal	antifungal	JJ
cord-017420-tjwxec77	156	21	agents	agent	NNS
cord-017420-tjwxec77	156	22	in	in	IN
cord-017420-tjwxec77	156	23	all	all	DT
cord-017420-tjwxec77	156	24	patients	patient	NNS
cord-017420-tjwxec77	156	25	with	with	IN
cord-017420-tjwxec77	156	26	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	156	27	fever	fever	NN
cord-017420-tjwxec77	156	28	.	.	.
cord-017420-tjwxec77	157	1	In	in	IN
cord-017420-tjwxec77	157	2	general	general	JJ
cord-017420-tjwxec77	157	3	,	,	,
cord-017420-tjwxec77	157	4	antifungal	antifungal	JJ
cord-017420-tjwxec77	157	5	therapy	therapy	NN
cord-017420-tjwxec77	157	6	should	should	MD
cord-017420-tjwxec77	157	7	be	be	VB
cord-017420-tjwxec77	157	8	initiated	initiate	VBN
cord-017420-tjwxec77	157	9	in	in	IN
cord-017420-tjwxec77	157	10	the	the	DT
cord-017420-tjwxec77	157	11	setting	setting	NN
cord-017420-tjwxec77	157	12	of	of	IN
cord-017420-tjwxec77	157	13	persistent	persistent	JJ
cord-017420-tjwxec77	157	14	fever	fever	NN
cord-017420-tjwxec77	157	15	after	after	IN
cord-017420-tjwxec77	157	16	5	5	CD
cord-017420-tjwxec77	157	17	-	-	SYM
cord-017420-tjwxec77	157	18	7	7	CD
cord-017420-tjwxec77	157	19	days	day	NNS
cord-017420-tjwxec77	157	20	of	of	IN
cord-017420-tjwxec77	157	21	appropriate	appropriate	JJ
cord-017420-tjwxec77	157	22	antibacterials	antibacterial	NNS
cord-017420-tjwxec77	157	23	[	[	-LRB-
cord-017420-tjwxec77	157	24	28	28	CD
cord-017420-tjwxec77	157	25	,	,	,
cord-017420-tjwxec77	157	26	33	33	CD
cord-017420-tjwxec77	157	27	]	]	-RRB-
cord-017420-tjwxec77	157	28	.	.	.
cord-017420-tjwxec77	158	1	Appropriate	appropriate	JJ
cord-017420-tjwxec77	158	2	antifungals	antifungal	NNS
cord-017420-tjwxec77	158	3	should	should	MD
cord-017420-tjwxec77	158	4	have	have	VB
cord-017420-tjwxec77	158	5	activity	activity	NN
cord-017420-tjwxec77	158	6	against	against	IN
cord-017420-tjwxec77	158	7	molds	mold	NNS
cord-017420-tjwxec77	158	8	,	,	,
cord-017420-tjwxec77	158	9	especially	especially	RB
cord-017420-tjwxec77	158	10	aspergillosis	aspergillosis	NN
cord-017420-tjwxec77	158	11	;	;	:
cord-017420-tjwxec77	158	12	examples	example	NNS
cord-017420-tjwxec77	158	13	include	include	VBP
cord-017420-tjwxec77	158	14	liposomal	liposomal	IN
cord-017420-tjwxec77	158	15	amphotericin	amphotericin	NNS
cord-017420-tjwxec77	158	16	,	,	,
cord-017420-tjwxec77	158	17	caspofungin	caspofungin	NNP
cord-017420-tjwxec77	158	18	,	,	,
cord-017420-tjwxec77	158	19	and	and	CC
cord-017420-tjwxec77	158	20	voriconazole	voriconazole	NNP
cord-017420-tjwxec77	158	21	,	,	,
cord-017420-tjwxec77	158	22	though	though	IN
cord-017420-tjwxec77	158	23	the	the	DT
cord-017420-tjwxec77	158	24	data	datum	NNS
cord-017420-tjwxec77	158	25	are	be	VBP
cord-017420-tjwxec77	158	26	more	more	RBR
cord-017420-tjwxec77	158	27	robust	robust	JJ
cord-017420-tjwxec77	158	28	in	in	IN
cord-017420-tjwxec77	158	29	favor	favor	NN
cord-017420-tjwxec77	158	30	of	of	IN
cord-017420-tjwxec77	158	31	the	the	DT
cord-017420-tjwxec77	158	32	former	former	JJ
cord-017420-tjwxec77	158	33	two	two	CD
cord-017420-tjwxec77	158	34	[	[	-LRB-
cord-017420-tjwxec77	158	35	33	33	CD
cord-017420-tjwxec77	158	36	,	,	,
cord-017420-tjwxec77	158	37	81	81	CD
cord-017420-tjwxec77	158	38	,	,	,
cord-017420-tjwxec77	158	39	82	82	CD
cord-017420-tjwxec77	158	40	]	]	-RRB-
cord-017420-tjwxec77	158	41	.	.	.
cord-017420-tjwxec77	159	1	Fluconazole	fluconazole	NN
cord-017420-tjwxec77	159	2	should	should	MD
cord-017420-tjwxec77	159	3	not	not	RB
cord-017420-tjwxec77	159	4	be	be	VB
cord-017420-tjwxec77	159	5	used	use	VBN
cord-017420-tjwxec77	159	6	as	as	IN
cord-017420-tjwxec77	159	7	empiric	empiric	JJ
cord-017420-tjwxec77	159	8	therapy	therapy	NN
cord-017420-tjwxec77	159	9	.	.	.
cord-017420-tjwxec77	160	1	An	an	DT
cord-017420-tjwxec77	160	2	increasing	increase	VBG
cord-017420-tjwxec77	160	3	number	number	NN
cord-017420-tjwxec77	160	4	of	of	IN
cord-017420-tjwxec77	160	5	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	160	6	patients	patient	NNS
cord-017420-tjwxec77	160	7	are	be	VBP
cord-017420-tjwxec77	160	8	on	on	IN
cord-017420-tjwxec77	160	9	antifungal	antifungal	JJ
cord-017420-tjwxec77	160	10	prophylaxis	prophylaxis	NN
cord-017420-tjwxec77	160	11	with	with	IN
cord-017420-tjwxec77	160	12	voriconazole	voriconazole	NN
cord-017420-tjwxec77	160	13	prior	prior	RB
cord-017420-tjwxec77	160	14	to	to	IN
cord-017420-tjwxec77	160	15	developing	develop	VBG
cord-017420-tjwxec77	160	16	fever	fever	NN
cord-017420-tjwxec77	160	17	;	;	:
cord-017420-tjwxec77	160	18	the	the	DT
cord-017420-tjwxec77	160	19	utility	utility	NN
cord-017420-tjwxec77	160	20	of	of	IN
cord-017420-tjwxec77	160	21	changing	change	VBG
cord-017420-tjwxec77	160	22	antifungal	antifungal	JJ
cord-017420-tjwxec77	160	23	agents	agent	NNS
cord-017420-tjwxec77	160	24	upon	upon	IN
cord-017420-tjwxec77	160	25	fever	fever	NN
cord-017420-tjwxec77	160	26	development	development	NN
cord-017420-tjwxec77	160	27	in	in	IN
cord-017420-tjwxec77	160	28	this	this	DT
cord-017420-tjwxec77	160	29	setting	setting	NN
cord-017420-tjwxec77	160	30	is	be	VBZ
cord-017420-tjwxec77	160	31	unclear	unclear	JJ
cord-017420-tjwxec77	160	32	.	.	.
cord-017420-tjwxec77	161	1	Antifungals	antifungal	NNS
cord-017420-tjwxec77	161	2	should	should	MD
cord-017420-tjwxec77	161	3	be	be	VB
cord-017420-tjwxec77	161	4	strongly	strongly	RB
cord-017420-tjwxec77	161	5	considered	consider	VBN
cord-017420-tjwxec77	161	6	as	as	IN
cord-017420-tjwxec77	161	7	early	early	JJ
cord-017420-tjwxec77	161	8	therapy	therapy	NN
cord-017420-tjwxec77	161	9	in	in	IN
cord-017420-tjwxec77	161	10	all	all	DT
cord-017420-tjwxec77	161	11	patients	patient	NNS
cord-017420-tjwxec77	161	12	who	who	WP
cord-017420-tjwxec77	161	13	are	be	VBP
cord-017420-tjwxec77	161	14	hemodynamically	hemodynamically	RB
cord-017420-tjwxec77	161	15	unstable	unstable	JJ
cord-017420-tjwxec77	161	16	[	[	-LRB-
cord-017420-tjwxec77	161	17	28	28	CD
cord-017420-tjwxec77	161	18	,	,	,
cord-017420-tjwxec77	161	19	33	33	CD
cord-017420-tjwxec77	161	20	]	]	-RRB-
cord-017420-tjwxec77	161	21	.	.	.
cord-017420-tjwxec77	162	1	With	with	IN
cord-017420-tjwxec77	162	2	the	the	DT
cord-017420-tjwxec77	162	3	advent	advent	NN
cord-017420-tjwxec77	162	4	of	of	IN
cord-017420-tjwxec77	162	5	multidrug	multidrug	NN
cord-017420-tjwxec77	162	6	-	-	HYPH
cord-017420-tjwxec77	162	7	resistant	resistant	JJ
cord-017420-tjwxec77	162	8	organisms	organism	NNS
cord-017420-tjwxec77	162	9	,	,	,
cord-017420-tjwxec77	162	10	antibiotic	antibiotic	JJ
cord-017420-tjwxec77	162	11	stewardship	stewardship	NN
cord-017420-tjwxec77	162	12	is	be	VBZ
cord-017420-tjwxec77	162	13	increasingly	increasingly	RB
cord-017420-tjwxec77	162	14	important	important	JJ
cord-017420-tjwxec77	162	15	,	,	,
cord-017420-tjwxec77	162	16	even	even	RB
cord-017420-tjwxec77	162	17	in	in	IN
cord-017420-tjwxec77	162	18	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	162	19	patients	patient	NNS
cord-017420-tjwxec77	162	20	.	.	.
cord-017420-tjwxec77	163	1	The	the	DT
cord-017420-tjwxec77	163	2	optimum	optimum	JJ
cord-017420-tjwxec77	163	3	duration	duration	NN
cord-017420-tjwxec77	163	4	of	of	IN
cord-017420-tjwxec77	163	5	antimicrobial	antimicrobial	JJ
cord-017420-tjwxec77	163	6	therapy	therapy	NN
cord-017420-tjwxec77	163	7	in	in	IN
cord-017420-tjwxec77	163	8	the	the	DT
cord-017420-tjwxec77	163	9	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	163	10	patient	patient	NN
cord-017420-tjwxec77	163	11	and	and	CC
cord-017420-tjwxec77	163	12	whether	whether	IN
cord-017420-tjwxec77	163	13	antimicrobials	antimicrobial	NNS
cord-017420-tjwxec77	163	14	may	may	MD
cord-017420-tjwxec77	163	15	be	be	VB
cord-017420-tjwxec77	163	16	safely	safely	RB
cord-017420-tjwxec77	163	17	de	de	VBN
cord-017420-tjwxec77	163	18	-	-	VBN
cord-017420-tjwxec77	163	19	escalated	escalate	VBN
cord-017420-tjwxec77	163	20	in	in	IN
cord-017420-tjwxec77	163	21	the	the	DT
cord-017420-tjwxec77	163	22	face	face	NN
cord-017420-tjwxec77	163	23	of	of	IN
cord-017420-tjwxec77	163	24	clinical	clinical	JJ
cord-017420-tjwxec77	163	25	stability	stability	NN
cord-017420-tjwxec77	163	26	are	be	VBP
cord-017420-tjwxec77	163	27	ongoing	ongoing	JJ
cord-017420-tjwxec77	163	28	areas	area	NNS
cord-017420-tjwxec77	163	29	of	of	IN
cord-017420-tjwxec77	163	30	investigation	investigation	NN
cord-017420-tjwxec77	163	31	.	.	.
cord-017420-tjwxec77	164	1	One	one	CD
cord-017420-tjwxec77	164	2	randomized	randomize	VBN
cord-017420-tjwxec77	164	3	controlled	control	VBN
cord-017420-tjwxec77	164	4	trial	trial	NN
cord-017420-tjwxec77	164	5	suggests	suggest	VBZ
cord-017420-tjwxec77	164	6	that	that	IN
cord-017420-tjwxec77	164	7	empiric	empiric	JJ
cord-017420-tjwxec77	164	8	antibiotics	antibiotic	NNS
cord-017420-tjwxec77	164	9	may	may	MD
cord-017420-tjwxec77	164	10	be	be	VB
cord-017420-tjwxec77	164	11	safely	safely	RB
cord-017420-tjwxec77	164	12	discontinued	discontinue	VBN
cord-017420-tjwxec77	164	13	after	after	IN
cord-017420-tjwxec77	164	14	a	a	DT
cord-017420-tjwxec77	164	15	patient	patient	NN
cord-017420-tjwxec77	164	16	has	have	VBZ
cord-017420-tjwxec77	164	17	defervesced	defervesce	VBN
cord-017420-tjwxec77	164	18	and	and	CC
cord-017420-tjwxec77	164	19	remained	remain	VBD
cord-017420-tjwxec77	164	20	afebrile	afebrile	JJ
cord-017420-tjwxec77	164	21	for	for	IN
cord-017420-tjwxec77	164	22	72	72	CD
cord-017420-tjwxec77	164	23	h	h	NN
cord-017420-tjwxec77	164	24	,	,	,
cord-017420-tjwxec77	164	25	regardless	regardless	RB
cord-017420-tjwxec77	164	26	of	of	IN
cord-017420-tjwxec77	164	27	whether	whether	IN
cord-017420-tjwxec77	164	28	neutrophil	neutrophil	NN
cord-017420-tjwxec77	164	29	recovery	recovery	NN
cord-017420-tjwxec77	164	30	has	have	VBZ
cord-017420-tjwxec77	164	31	occurred	occur	VBN
cord-017420-tjwxec77	164	32	[	[	-LRB-
cord-017420-tjwxec77	164	33	2	2	CD
cord-017420-tjwxec77	164	34	]	]	-RRB-
cord-017420-tjwxec77	164	35	.	.	.
cord-017420-tjwxec77	165	1	Another	another	DT
cord-017420-tjwxec77	165	2	recent	recent	JJ
cord-017420-tjwxec77	165	3	paper	paper	NN
cord-017420-tjwxec77	165	4	suggested	suggest	VBD
cord-017420-tjwxec77	165	5	that	that	IN
cord-017420-tjwxec77	165	6	it	-PRON-	PRP
cord-017420-tjwxec77	165	7	is	be	VBZ
cord-017420-tjwxec77	165	8	safe	safe	JJ
cord-017420-tjwxec77	165	9	to	to	TO
cord-017420-tjwxec77	165	10	withhold	withhold	VB
cord-017420-tjwxec77	165	11	antibacterial	antibacterial	JJ
cord-017420-tjwxec77	165	12	therapy	therapy	NN
cord-017420-tjwxec77	165	13	in	in	IN
cord-017420-tjwxec77	165	14	children	child	NNS
cord-017420-tjwxec77	165	15	with	with	IN
cord-017420-tjwxec77	165	16	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	165	17	fever	fever	NN
cord-017420-tjwxec77	165	18	in	in	IN
cord-017420-tjwxec77	165	19	whom	whom	WP
cord-017420-tjwxec77	165	20	infection	infection	NN
cord-017420-tjwxec77	165	21	with	with	IN
cord-017420-tjwxec77	165	22	a	a	DT
cord-017420-tjwxec77	165	23	respiratory	respiratory	JJ
cord-017420-tjwxec77	165	24	virus	virus	NN
cord-017420-tjwxec77	165	25	has	have	VBZ
cord-017420-tjwxec77	165	26	been	be	VBN
cord-017420-tjwxec77	165	27	proven	prove	VBN
cord-017420-tjwxec77	165	28	[	[	-LRB-
cord-017420-tjwxec77	165	29	65	65	CD
cord-017420-tjwxec77	165	30	]	]	-RRB-
cord-017420-tjwxec77	165	31	.	.	.
cord-017420-tjwxec77	166	1	Neither	neither	DT
cord-017420-tjwxec77	166	2	of	of	IN
cord-017420-tjwxec77	166	3	these	these	DT
cord-017420-tjwxec77	166	4	tactics	tactic	NNS
cord-017420-tjwxec77	166	5	has	have	VBZ
cord-017420-tjwxec77	166	6	become	become	VBN
cord-017420-tjwxec77	166	7	standard	standard	NN
cord-017420-tjwxec77	166	8	of	of	IN
cord-017420-tjwxec77	166	9	care	care	NN
cord-017420-tjwxec77	166	10	,	,	,
cord-017420-tjwxec77	166	11	but	but	CC
cord-017420-tjwxec77	166	12	both	both	DT
cord-017420-tjwxec77	166	13	highlight	highlight	VBP
cord-017420-tjwxec77	166	14	the	the	DT
cord-017420-tjwxec77	166	15	increasingly	increasingly	RB
cord-017420-tjwxec77	166	16	realized	realize	VBN
cord-017420-tjwxec77	166	17	importance	importance	NN
cord-017420-tjwxec77	166	18	of	of	IN
cord-017420-tjwxec77	166	19	antibiotic	antibiotic	JJ
cord-017420-tjwxec77	166	20	stewardship	stewardship	NN
cord-017420-tjwxec77	166	21	,	,	,
cord-017420-tjwxec77	166	22	even	even	RB
cord-017420-tjwxec77	166	23	in	in	IN
cord-017420-tjwxec77	166	24	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	166	25	patients	patient	NNS
cord-017420-tjwxec77	166	26	.	.	.
cord-017420-tjwxec77	167	1	Hematopoietic	hematopoietic	JJ
cord-017420-tjwxec77	167	2	growth	growth	NN
cord-017420-tjwxec77	167	3	factors	factor	NNS
cord-017420-tjwxec77	167	4	may	may	MD
cord-017420-tjwxec77	167	5	be	be	VB
cord-017420-tjwxec77	167	6	considered	consider	VBN
cord-017420-tjwxec77	167	7	in	in	IN
cord-017420-tjwxec77	167	8	select	select	JJ
cord-017420-tjwxec77	167	9	cases	case	NNS
cord-017420-tjwxec77	167	10	of	of	IN
cord-017420-tjwxec77	167	11	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	167	12	fever	fever	NN
cord-017420-tjwxec77	167	13	,	,	,
cord-017420-tjwxec77	167	14	as	as	IN
cord-017420-tjwxec77	167	15	they	-PRON-	PRP
cord-017420-tjwxec77	167	16	have	have	VBP
cord-017420-tjwxec77	167	17	been	be	VBN
cord-017420-tjwxec77	167	18	shown	show	VBN
cord-017420-tjwxec77	167	19	to	to	TO
cord-017420-tjwxec77	167	20	shorten	shorten	VB
cord-017420-tjwxec77	167	21	the	the	DT
cord-017420-tjwxec77	167	22	duration	duration	NN
cord-017420-tjwxec77	167	23	of	of	IN
cord-017420-tjwxec77	167	24	neutropenia	neutropenia	NN
cord-017420-tjwxec77	167	25	,	,	,
cord-017420-tjwxec77	167	26	but	but	CC
cord-017420-tjwxec77	167	27	do	do	VBP
cord-017420-tjwxec77	167	28	not	not	RB
cord-017420-tjwxec77	167	29	impact	impact	VB
cord-017420-tjwxec77	167	30	mortality	mortality	NN
cord-017420-tjwxec77	167	31	[	[	-LRB-
cord-017420-tjwxec77	167	32	22	22	CD
cord-017420-tjwxec77	167	33	]	]	-RRB-
cord-017420-tjwxec77	167	34	.	.	.
cord-017420-tjwxec77	168	1	According	accord	VBG
cord-017420-tjwxec77	168	2	,	,	,
cord-017420-tjwxec77	168	3	due	due	IN
cord-017420-tjwxec77	168	4	to	to	IN
cord-017420-tjwxec77	168	5	a	a	DT
cord-017420-tjwxec77	168	6	lack	lack	NN
cord-017420-tjwxec77	168	7	of	of	IN
cord-017420-tjwxec77	168	8	proven	prove	VBN
cord-017420-tjwxec77	168	9	mortality	mortality	NN
cord-017420-tjwxec77	168	10	benefit	benefit	NN
cord-017420-tjwxec77	168	11	,	,	,
cord-017420-tjwxec77	168	12	current	current	JJ
cord-017420-tjwxec77	168	13	guidelines	guideline	NNS
cord-017420-tjwxec77	168	14	recommend	recommend	VBP
cord-017420-tjwxec77	168	15	against	against	IN
cord-017420-tjwxec77	168	16	the	the	DT
cord-017420-tjwxec77	168	17	routine	routine	JJ
cord-017420-tjwxec77	168	18	use	use	NN
cord-017420-tjwxec77	168	19	of	of	IN
cord-017420-tjwxec77	168	20	hematopoietic	hematopoietic	JJ
cord-017420-tjwxec77	168	21	growth	growth	NN
cord-017420-tjwxec77	168	22	factors	factor	NNS
cord-017420-tjwxec77	168	23	in	in	IN
cord-017420-tjwxec77	168	24	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	168	25	fever	fever	NN
cord-017420-tjwxec77	168	26	or	or	CC
cord-017420-tjwxec77	168	27	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	168	28	sepsis	sepsis	NN
cord-017420-tjwxec77	168	29	[	[	-LRB-
cord-017420-tjwxec77	168	30	29	29	CD
cord-017420-tjwxec77	168	31	,	,	,
cord-017420-tjwxec77	168	32	72	72	CD
cord-017420-tjwxec77	168	33	]	]	-RRB-
cord-017420-tjwxec77	168	34	.	.	.
cord-017420-tjwxec77	169	1	Granulocyte	granulocyte	NN
cord-017420-tjwxec77	169	2	transfusions	transfusion	NNS
cord-017420-tjwxec77	169	3	have	have	VBP
cord-017420-tjwxec77	169	4	been	be	VBN
cord-017420-tjwxec77	169	5	used	use	VBN
cord-017420-tjwxec77	169	6	to	to	TO
cord-017420-tjwxec77	169	7	support	support	VB
cord-017420-tjwxec77	169	8	patients	patient	NNS
cord-017420-tjwxec77	169	9	with	with	IN
cord-017420-tjwxec77	169	10	neutropenia	neutropenia	NN
cord-017420-tjwxec77	169	11	,	,	,
cord-017420-tjwxec77	169	12	both	both	DT
cord-017420-tjwxec77	169	13	to	to	TO
cord-017420-tjwxec77	169	14	prevent	prevent	VB
cord-017420-tjwxec77	169	15	infections	infection	NNS
cord-017420-tjwxec77	169	16	and	and	CC
cord-017420-tjwxec77	169	17	to	to	TO
cord-017420-tjwxec77	169	18	help	help	VB
cord-017420-tjwxec77	169	19	treat	treat	VB
cord-017420-tjwxec77	169	20	established	established	JJ
cord-017420-tjwxec77	169	21	infections	infection	NNS
cord-017420-tjwxec77	169	22	.	.	.
cord-017420-tjwxec77	170	1	Very	very	RB
cord-017420-tjwxec77	170	2	few	few	JJ
cord-017420-tjwxec77	170	3	studies	study	NNS
cord-017420-tjwxec77	170	4	have	have	VBP
cord-017420-tjwxec77	170	5	been	be	VBN
cord-017420-tjwxec77	170	6	performed	perform	VBN
cord-017420-tjwxec77	170	7	to	to	TO
cord-017420-tjwxec77	170	8	evaluate	evaluate	VB
cord-017420-tjwxec77	170	9	this	this	DT
cord-017420-tjwxec77	170	10	intervention	intervention	NN
cord-017420-tjwxec77	170	11	,	,	,
cord-017420-tjwxec77	170	12	and	and	CC
cord-017420-tjwxec77	170	13	those	those	DT
cord-017420-tjwxec77	170	14	studies	study	NNS
cord-017420-tjwxec77	170	15	that	that	WDT
cord-017420-tjwxec77	170	16	are	be	VBP
cord-017420-tjwxec77	170	17	available	available	JJ
cord-017420-tjwxec77	170	18	are	be	VBP
cord-017420-tjwxec77	170	19	small	small	JJ
cord-017420-tjwxec77	170	20	.	.	.
cord-017420-tjwxec77	171	1	Two	two	CD
cord-017420-tjwxec77	171	2	recent	recent	JJ
cord-017420-tjwxec77	171	3	Cochrane	Cochrane	NNP
cord-017420-tjwxec77	171	4	metaanalyses	metaanalyse	NNS
cord-017420-tjwxec77	171	5	have	have	VBP
cord-017420-tjwxec77	171	6	examined	examine	VBN
cord-017420-tjwxec77	171	7	the	the	DT
cord-017420-tjwxec77	171	8	use	use	NN
cord-017420-tjwxec77	171	9	of	of	IN
cord-017420-tjwxec77	171	10	granulocyte	granulocyte	NN
cord-017420-tjwxec77	171	11	transfusions	transfusion	NNS
cord-017420-tjwxec77	171	12	in	in	IN
cord-017420-tjwxec77	171	13	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	171	14	patients	patient	NNS
cord-017420-tjwxec77	171	15	to	to	TO
cord-017420-tjwxec77	171	16	prevent	prevent	VB
cord-017420-tjwxec77	171	17	and	and	CC
cord-017420-tjwxec77	171	18	treat	treat	VB
cord-017420-tjwxec77	171	19	infections	infection	NNS
cord-017420-tjwxec77	171	20	,	,	,
cord-017420-tjwxec77	171	21	respectively	respectively	RB
cord-017420-tjwxec77	171	22	.	.	.
cord-017420-tjwxec77	172	1	Both	both	DT
cord-017420-tjwxec77	172	2	concluded	conclude	VBD
cord-017420-tjwxec77	172	3	that	that	IN
cord-017420-tjwxec77	172	4	there	there	EX
cord-017420-tjwxec77	172	5	was	be	VBD
cord-017420-tjwxec77	172	6	insufficient	insufficient	JJ
cord-017420-tjwxec77	172	7	evidence	evidence	NN
cord-017420-tjwxec77	172	8	to	to	TO
cord-017420-tjwxec77	172	9	determine	determine	VB
cord-017420-tjwxec77	172	10	whether	whether	IN
cord-017420-tjwxec77	172	11	granulocyte	granulocyte	NN
cord-017420-tjwxec77	172	12	transfusions	transfusion	NNS
cord-017420-tjwxec77	172	13	conferred	confer	VBD
cord-017420-tjwxec77	172	14	any	any	DT
cord-017420-tjwxec77	172	15	mortality	mortality	NN
cord-017420-tjwxec77	172	16	benefit	benefit	NN
cord-017420-tjwxec77	172	17	[	[	-LRB-
cord-017420-tjwxec77	172	18	24	24	CD
cord-017420-tjwxec77	172	19	,	,	,
cord-017420-tjwxec77	172	20	25	25	CD
cord-017420-tjwxec77	172	21	]	]	-RRB-
cord-017420-tjwxec77	172	22	.	.	.
cord-017420-tjwxec77	173	1	Early	early	JJ
cord-017420-tjwxec77	173	2	and	and	CC
cord-017420-tjwxec77	173	3	appropriate	appropriate	JJ
cord-017420-tjwxec77	173	4	administration	administration	NN
cord-017420-tjwxec77	173	5	of	of	IN
cord-017420-tjwxec77	173	6	antimicrobials	antimicrobial	NNS
cord-017420-tjwxec77	173	7	is	be	VBZ
cord-017420-tjwxec77	173	8	essential	essential	JJ
cord-017420-tjwxec77	173	9	to	to	IN
cord-017420-tjwxec77	173	10	preventing	prevent	VBG
cord-017420-tjwxec77	173	11	death	death	NN
cord-017420-tjwxec77	173	12	from	from	IN
cord-017420-tjwxec77	173	13	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	173	14	fever	fever	NN
cord-017420-tjwxec77	173	15	and	and	CC
cord-017420-tjwxec77	173	16	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	173	17	sepsis	sepsis	NN
cord-017420-tjwxec77	173	18	.	.	.
cord-017420-tjwxec77	174	1	Good	good	JJ
cord-017420-tjwxec77	174	2	outcomes	outcome	NNS
cord-017420-tjwxec77	174	3	also	also	RB
cord-017420-tjwxec77	174	4	depend	depend	VBP
cord-017420-tjwxec77	174	5	on	on	IN
cord-017420-tjwxec77	174	6	successfully	successfully	RB
cord-017420-tjwxec77	174	7	managing	manage	VBG
cord-017420-tjwxec77	174	8	the	the	DT
cord-017420-tjwxec77	174	9	hemodynamic	hemodynamic	JJ
cord-017420-tjwxec77	174	10	derangements	derangement	NNS
cord-017420-tjwxec77	174	11	and	and	CC
cord-017420-tjwxec77	174	12	organ	organ	NN
cord-017420-tjwxec77	174	13	failure	failure	NN
cord-017420-tjwxec77	174	14	of	of	IN
cord-017420-tjwxec77	174	15	sepsis	sepsis	NN
cord-017420-tjwxec77	174	16	.	.	.
cord-017420-tjwxec77	175	1	The	the	DT
cord-017420-tjwxec77	175	2	intensive	intensive	JJ
cord-017420-tjwxec77	175	3	care	care	NN
cord-017420-tjwxec77	175	4	unit	unit	NN
cord-017420-tjwxec77	175	5	(	(	-LRB-
cord-017420-tjwxec77	175	6	ICU	ICU	NNP
cord-017420-tjwxec77	175	7	)	)	-RRB-
cord-017420-tjwxec77	175	8	is	be	VBZ
cord-017420-tjwxec77	175	9	the	the	DT
cord-017420-tjwxec77	175	10	bestsuited	bestsuited	JJ
cord-017420-tjwxec77	175	11	location	location	NN
cord-017420-tjwxec77	175	12	to	to	TO
cord-017420-tjwxec77	175	13	care	care	VB
cord-017420-tjwxec77	175	14	for	for	IN
cord-017420-tjwxec77	175	15	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	175	16	patients	patient	NNS
cord-017420-tjwxec77	175	17	with	with	IN
cord-017420-tjwxec77	175	18	sepsis	sepsis	NN
cord-017420-tjwxec77	175	19	and	and	CC
cord-017420-tjwxec77	175	20	septic	septic	JJ
cord-017420-tjwxec77	175	21	shock	shock	NN
cord-017420-tjwxec77	175	22	,	,	,
cord-017420-tjwxec77	175	23	and	and	CC
cord-017420-tjwxec77	175	24	earlier	early	JJR
cord-017420-tjwxec77	175	25	ICU	ICU	NNP
cord-017420-tjwxec77	175	26	admission	admission	NN
cord-017420-tjwxec77	175	27	has	have	VBZ
cord-017420-tjwxec77	175	28	been	be	VBN
cord-017420-tjwxec77	175	29	associated	associate	VBN
cord-017420-tjwxec77	175	30	with	with	IN
cord-017420-tjwxec77	175	31	improved	improved	JJ
cord-017420-tjwxec77	175	32	survival	survival	NN
cord-017420-tjwxec77	175	33	rates	rate	NNS
cord-017420-tjwxec77	175	34	[	[	-LRB-
cord-017420-tjwxec77	175	35	7	7	CD
cord-017420-tjwxec77	175	36	,	,	,
cord-017420-tjwxec77	175	37	9	9	CD
cord-017420-tjwxec77	175	38	]	]	-RRB-
cord-017420-tjwxec77	175	39	.	.	.
cord-017420-tjwxec77	176	1	Recent	recent	JJ
cord-017420-tjwxec77	176	2	guidelines	guideline	NNS
cord-017420-tjwxec77	176	3	have	have	VBP
cord-017420-tjwxec77	176	4	been	be	VBN
cord-017420-tjwxec77	176	5	published	publish	VBN
cord-017420-tjwxec77	176	6	for	for	IN
cord-017420-tjwxec77	176	7	the	the	DT
cord-017420-tjwxec77	176	8	management	management	NN
cord-017420-tjwxec77	176	9	of	of	IN
cord-017420-tjwxec77	176	10	sepsis	sepsis	NN
cord-017420-tjwxec77	176	11	and	and	CC
cord-017420-tjwxec77	176	12	septic	septic	JJ
cord-017420-tjwxec77	176	13	shock	shock	NN
cord-017420-tjwxec77	176	14	[	[	-LRB-
cord-017420-tjwxec77	176	15	61	61	CD
cord-017420-tjwxec77	176	16	]	]	-RRB-
cord-017420-tjwxec77	176	17	;	;	:
cord-017420-tjwxec77	176	18	these	these	DT
cord-017420-tjwxec77	176	19	guidelines	guideline	NNS
cord-017420-tjwxec77	176	20	are	be	VBP
cord-017420-tjwxec77	176	21	also	also	RB
cord-017420-tjwxec77	176	22	applicable	applicable	JJ
cord-017420-tjwxec77	176	23	to	to	IN
cord-017420-tjwxec77	176	24	the	the	DT
cord-017420-tjwxec77	176	25	management	management	NN
cord-017420-tjwxec77	176	26	of	of	IN
cord-017420-tjwxec77	176	27	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	176	28	sepsis	sepsis	NN
cord-017420-tjwxec77	176	29	.	.	.
cord-017420-tjwxec77	177	1	Key	key	JJ
cord-017420-tjwxec77	177	2	points	point	NNS
cord-017420-tjwxec77	177	3	include	include	VBP
cord-017420-tjwxec77	177	4	initial	initial	JJ
cord-017420-tjwxec77	177	5	resuscitation	resuscitation	NN
cord-017420-tjwxec77	177	6	with	with	IN
cord-017420-tjwxec77	177	7	at	at	RB
cord-017420-tjwxec77	177	8	least	least	RBS
cord-017420-tjwxec77	177	9	30	30	CD
cord-017420-tjwxec77	177	10	ml	ml	NN
cord-017420-tjwxec77	177	11	/	/	SYM
cord-017420-tjwxec77	177	12	kg	kg	NNS
cord-017420-tjwxec77	177	13	of	of	IN
cord-017420-tjwxec77	177	14	intravenous	intravenous	JJ
cord-017420-tjwxec77	177	15	crystalloid	crystalloid	NN
cord-017420-tjwxec77	177	16	with	with	IN
cord-017420-tjwxec77	177	17	additional	additional	JJ
cord-017420-tjwxec77	177	18	fluid	fluid	JJ
cord-017420-tjwxec77	177	19	resuscitation	resuscitation	NN
cord-017420-tjwxec77	177	20	as	as	IN
cord-017420-tjwxec77	177	21	indicated	indicate	VBN
cord-017420-tjwxec77	177	22	and	and	CC
cord-017420-tjwxec77	177	23	using	use	VBG
cord-017420-tjwxec77	177	24	norepinephrine	norepinephrine	NN
cord-017420-tjwxec77	177	25	as	as	IN
cord-017420-tjwxec77	177	26	a	a	DT
cord-017420-tjwxec77	177	27	first	first	JJ
cord-017420-tjwxec77	177	28	-	-	HYPH
cord-017420-tjwxec77	177	29	line	line	NN
cord-017420-tjwxec77	177	30	vasopressor	vasopressor	NN
cord-017420-tjwxec77	177	31	to	to	TO
cord-017420-tjwxec77	177	32	target	target	VB
cord-017420-tjwxec77	177	33	a	a	DT
cord-017420-tjwxec77	177	34	mean	mean	JJ
cord-017420-tjwxec77	177	35	arterial	arterial	JJ
cord-017420-tjwxec77	177	36	pressure	pressure	NN
cord-017420-tjwxec77	177	37	!	!	.
cord-017420-tjwxec77	178	1	65	65	CD
cord-017420-tjwxec77	178	2	mm	mm	CD
cord-017420-tjwxec77	178	3	Hg	Hg	NNS
cord-017420-tjwxec77	178	4	.	.	.
cord-017420-tjwxec77	179	1	Either	either	CC
cord-017420-tjwxec77	179	2	vasopressin	vasopressin	NN
cord-017420-tjwxec77	179	3	or	or	CC
cord-017420-tjwxec77	179	4	epinephrine	epinephrine	NN
cord-017420-tjwxec77	179	5	may	may	MD
cord-017420-tjwxec77	179	6	be	be	VB
cord-017420-tjwxec77	179	7	added	add	VBN
cord-017420-tjwxec77	179	8	if	if	IN
cord-017420-tjwxec77	179	9	the	the	DT
cord-017420-tjwxec77	179	10	response	response	NN
cord-017420-tjwxec77	179	11	to	to	IN
cord-017420-tjwxec77	179	12	norepinephrine	norepinephrine	NN
cord-017420-tjwxec77	179	13	is	be	VBZ
cord-017420-tjwxec77	179	14	inadequate	inadequate	JJ
cord-017420-tjwxec77	179	15	.	.	.
cord-017420-tjwxec77	180	1	There	there	EX
cord-017420-tjwxec77	180	2	may	may	MD
cord-017420-tjwxec77	180	3	be	be	VB
cord-017420-tjwxec77	180	4	benefit	benefit	NN
cord-017420-tjwxec77	180	5	to	to	IN
cord-017420-tjwxec77	180	6	using	use	VBG
cord-017420-tjwxec77	180	7	balanced	balanced	JJ
cord-017420-tjwxec77	180	8	crystalloid	crystalloid	NN
cord-017420-tjwxec77	180	9	solutions	solution	NNS
cord-017420-tjwxec77	180	10	such	such	JJ
cord-017420-tjwxec77	180	11	as	as	IN
cord-017420-tjwxec77	180	12	lactated	lactate	VBN
cord-017420-tjwxec77	180	13	Ringer	Ringer	NNP
cord-017420-tjwxec77	180	14	's	's	POS
cord-017420-tjwxec77	180	15	or	or	CC
cord-017420-tjwxec77	180	16	PlasmaLyte	PlasmaLyte	NNP
cord-017420-tjwxec77	180	17	rather	rather	RB
cord-017420-tjwxec77	180	18	than	than	IN
cord-017420-tjwxec77	180	19	normal	normal	JJ
cord-017420-tjwxec77	180	20	saline	saline	NN
cord-017420-tjwxec77	180	21	[	[	-LRB-
cord-017420-tjwxec77	180	22	68	68	CD
cord-017420-tjwxec77	180	23	,	,	,
cord-017420-tjwxec77	180	24	69	69	CD
cord-017420-tjwxec77	180	25	]	]	-RRB-
cord-017420-tjwxec77	180	26	.	.	.
cord-017420-tjwxec77	181	1	Source	source	NN
cord-017420-tjwxec77	181	2	control	control	NN
cord-017420-tjwxec77	181	3	should	should	MD
cord-017420-tjwxec77	181	4	be	be	VB
cord-017420-tjwxec77	181	5	obtained	obtain	VBN
cord-017420-tjwxec77	181	6	if	if	IN
cord-017420-tjwxec77	181	7	possible	possible	JJ
cord-017420-tjwxec77	181	8	.	.	.
cord-017420-tjwxec77	182	1	Though	though	IN
cord-017420-tjwxec77	182	2	occasionally	occasionally	RB
cord-017420-tjwxec77	182	3	an	an	DT
cord-017420-tjwxec77	182	4	abscess	abscess	NN
cord-017420-tjwxec77	182	5	may	may	MD
cord-017420-tjwxec77	182	6	be	be	VB
cord-017420-tjwxec77	182	7	present	present	JJ
cord-017420-tjwxec77	182	8	and	and	CC
cord-017420-tjwxec77	182	9	feasible	feasible	JJ
cord-017420-tjwxec77	182	10	to	to	TO
cord-017420-tjwxec77	182	11	drain	drain	VB
cord-017420-tjwxec77	182	12	,	,	,
cord-017420-tjwxec77	182	13	most	most	RBS
cord-017420-tjwxec77	182	14	commonly	commonly	RB
cord-017420-tjwxec77	182	15	,	,	,
cord-017420-tjwxec77	182	16	an	an	DT
cord-017420-tjwxec77	182	17	indwelling	indwell	VBG
cord-017420-tjwxec77	182	18	central	central	JJ
cord-017420-tjwxec77	182	19	venous	venous	JJ
cord-017420-tjwxec77	182	20	catheter	catheter	NN
cord-017420-tjwxec77	182	21	is	be	VBZ
cord-017420-tjwxec77	182	22	the	the	DT
cord-017420-tjwxec77	182	23	only	only	JJ
cord-017420-tjwxec77	182	24	addressable	addressable	JJ
cord-017420-tjwxec77	182	25	source	source	NN
cord-017420-tjwxec77	182	26	of	of	IN
cord-017420-tjwxec77	182	27	infection	infection	NN
cord-017420-tjwxec77	182	28	.	.	.
cord-017420-tjwxec77	183	1	In	in	IN
cord-017420-tjwxec77	183	2	the	the	DT
cord-017420-tjwxec77	183	3	hemodynamically	hemodynamically	RB
cord-017420-tjwxec77	183	4	unstable	unstable	JJ
cord-017420-tjwxec77	183	5	patient	patient	NN
cord-017420-tjwxec77	183	6	with	with	IN
cord-017420-tjwxec77	183	7	a	a	DT
cord-017420-tjwxec77	183	8	suspected	suspect	VBN
cord-017420-tjwxec77	183	9	catheter	catheter	NN
cord-017420-tjwxec77	183	10	infection	infection	NN
cord-017420-tjwxec77	183	11	,	,	,
cord-017420-tjwxec77	183	12	early	early	JJ
cord-017420-tjwxec77	183	13	catheter	catheter	NN
cord-017420-tjwxec77	183	14	removal	removal	NN
cord-017420-tjwxec77	183	15	is	be	VBZ
cord-017420-tjwxec77	183	16	associated	associate	VBN
cord-017420-tjwxec77	183	17	with	with	IN
cord-017420-tjwxec77	183	18	improved	improved	JJ
cord-017420-tjwxec77	183	19	survival	survival	NN
cord-017420-tjwxec77	183	20	[	[	-LRB-
cord-017420-tjwxec77	183	21	39	39	CD
cord-017420-tjwxec77	183	22	]	]	-RRB-
cord-017420-tjwxec77	183	23	;	;	:
cord-017420-tjwxec77	183	24	accordingly	accordingly	RB
cord-017420-tjwxec77	183	25	,	,	,
cord-017420-tjwxec77	183	26	infected	infected	JJ
cord-017420-tjwxec77	183	27	or	or	CC
cord-017420-tjwxec77	183	28	potentially	potentially	RB
cord-017420-tjwxec77	183	29	infected	infected	JJ
cord-017420-tjwxec77	183	30	catheters	catheter	NNS
cord-017420-tjwxec77	183	31	should	should	MD
cord-017420-tjwxec77	183	32	be	be	VB
cord-017420-tjwxec77	183	33	removed	remove	VBN
cord-017420-tjwxec77	183	34	without	without	IN
cord-017420-tjwxec77	183	35	delay	delay	NN
cord-017420-tjwxec77	183	36	.	.	.
cord-017420-tjwxec77	184	1	Patients	patient	NNS
cord-017420-tjwxec77	184	2	with	with	IN
cord-017420-tjwxec77	184	3	neutropenia	neutropenia	NN
cord-017420-tjwxec77	184	4	and	and	CC
cord-017420-tjwxec77	184	5	sepsis	sepsis	NN
cord-017420-tjwxec77	184	6	are	be	VBP
cord-017420-tjwxec77	184	7	at	at	IN
cord-017420-tjwxec77	184	8	high	high	JJ
cord-017420-tjwxec77	184	9	risk	risk	NN
cord-017420-tjwxec77	184	10	of	of	IN
cord-017420-tjwxec77	184	11	developing	develop	VBG
cord-017420-tjwxec77	184	12	multi	multi	JJ
cord-017420-tjwxec77	184	13	-	-	JJ
cord-017420-tjwxec77	184	14	organ	organ	JJ
cord-017420-tjwxec77	184	15	failure	failure	NN
cord-017420-tjwxec77	184	16	,	,	,
cord-017420-tjwxec77	184	17	particularly	particularly	RB
cord-017420-tjwxec77	184	18	the	the	DT
cord-017420-tjwxec77	184	19	acute	acute	JJ
cord-017420-tjwxec77	184	20	respiratory	respiratory	JJ
cord-017420-tjwxec77	184	21	distress	distress	NN
cord-017420-tjwxec77	184	22	syndrome	syndrome	NN
cord-017420-tjwxec77	184	23	(	(	-LRB-
cord-017420-tjwxec77	184	24	ARDS	ARDS	NNP
cord-017420-tjwxec77	184	25	)	)	-RRB-
cord-017420-tjwxec77	184	26	[	[	-LRB-
cord-017420-tjwxec77	184	27	4	4	CD
cord-017420-tjwxec77	184	28	,	,	,
cord-017420-tjwxec77	184	29	5	5	CD
cord-017420-tjwxec77	184	30	]	]	-RRB-
cord-017420-tjwxec77	184	31	.	.	.
cord-017420-tjwxec77	185	1	The	the	DT
cord-017420-tjwxec77	185	2	use	use	NN
cord-017420-tjwxec77	185	3	of	of	IN
cord-017420-tjwxec77	185	4	noninvasive	noninvasive	JJ
cord-017420-tjwxec77	185	5	ventilation	ventilation	NN
cord-017420-tjwxec77	185	6	in	in	IN
cord-017420-tjwxec77	185	7	immunosuppressed	immunosuppressed	JJ
cord-017420-tjwxec77	185	8	patients	patient	NNS
cord-017420-tjwxec77	185	9	with	with	IN
cord-017420-tjwxec77	185	10	hypoxemic	hypoxemic	JJ
cord-017420-tjwxec77	185	11	respiratory	respiratory	JJ
cord-017420-tjwxec77	185	12	failure	failure	NN
cord-017420-tjwxec77	185	13	is	be	VBZ
cord-017420-tjwxec77	185	14	increasingly	increasingly	RB
cord-017420-tjwxec77	185	15	controversial	controversial	JJ
cord-017420-tjwxec77	185	16	,	,	,
cord-017420-tjwxec77	185	17	and	and	CC
cord-017420-tjwxec77	185	18	heated	heat	VBN
cord-017420-tjwxec77	185	19	humidified	humidified	JJ
cord-017420-tjwxec77	185	20	high	high	JJ
cord-017420-tjwxec77	185	21	-	-	HYPH
cord-017420-tjwxec77	185	22	flow	flow	NN
cord-017420-tjwxec77	185	23	oxygen	oxygen	NN
cord-017420-tjwxec77	185	24	may	may	MD
cord-017420-tjwxec77	185	25	be	be	VB
cord-017420-tjwxec77	185	26	a	a	DT
cord-017420-tjwxec77	185	27	better	well	JJR
cord-017420-tjwxec77	185	28	option	option	NN
cord-017420-tjwxec77	185	29	[	[	-LRB-
cord-017420-tjwxec77	185	30	5	5	CD
cord-017420-tjwxec77	185	31	,	,	,
cord-017420-tjwxec77	185	32	15	15	CD
cord-017420-tjwxec77	185	33	,	,	,
cord-017420-tjwxec77	185	34	27	27	CD
cord-017420-tjwxec77	185	35	,	,	,
cord-017420-tjwxec77	185	36	41	41	CD
cord-017420-tjwxec77	185	37	,	,	,
cord-017420-tjwxec77	185	38	42	42	CD
cord-017420-tjwxec77	185	39	,	,	,
cord-017420-tjwxec77	185	40	52	52	CD
cord-017420-tjwxec77	185	41	]	]	-RRB-
cord-017420-tjwxec77	185	42	.	.	.
cord-017420-tjwxec77	186	1	Once	once	IN
cord-017420-tjwxec77	186	2	patients	patient	NNS
cord-017420-tjwxec77	186	3	are	be	VBP
cord-017420-tjwxec77	186	4	intubated	intubate	VBN
cord-017420-tjwxec77	186	5	,	,	,
cord-017420-tjwxec77	186	6	low	low	JJ
cord-017420-tjwxec77	186	7	tidal	tidal	JJ
cord-017420-tjwxec77	186	8	volume	volume	NN
cord-017420-tjwxec77	186	9	ventilation	ventilation	NN
cord-017420-tjwxec77	186	10	should	should	MD
cord-017420-tjwxec77	186	11	be	be	VB
cord-017420-tjwxec77	186	12	used	use	VBN
cord-017420-tjwxec77	186	13	to	to	TO
cord-017420-tjwxec77	186	14	maximize	maximize	VB
cord-017420-tjwxec77	186	15	lung	lung	NN
cord-017420-tjwxec77	186	16	protection	protection	NN
cord-017420-tjwxec77	186	17	and	and	CC
cord-017420-tjwxec77	186	18	minimize	minimize	VB
cord-017420-tjwxec77	186	19	ventilator	ventilator	NN
cord-017420-tjwxec77	186	20	-	-	HYPH
cord-017420-tjwxec77	186	21	induced	induce	VBN
cord-017420-tjwxec77	186	22	lung	lung	NN
cord-017420-tjwxec77	186	23	injury	injury	NN
cord-017420-tjwxec77	186	24	[	[	-LRB-
cord-017420-tjwxec77	186	25	1	1	CD
cord-017420-tjwxec77	186	26	]	]	-RRB-
cord-017420-tjwxec77	186	27	.	.	.
cord-017420-tjwxec77	187	1	Adjuncts	adjunct	NNS
cord-017420-tjwxec77	187	2	such	such	JJ
cord-017420-tjwxec77	187	3	as	as	IN
cord-017420-tjwxec77	187	4	neuromuscular	neuromuscular	JJ
cord-017420-tjwxec77	187	5	blockade	blockade	NN
cord-017420-tjwxec77	187	6	and	and	CC
cord-017420-tjwxec77	187	7	prone	prone	JJ
cord-017420-tjwxec77	187	8	positioning	positioning	NN
cord-017420-tjwxec77	187	9	should	should	MD
cord-017420-tjwxec77	187	10	be	be	VB
cord-017420-tjwxec77	187	11	used	use	VBN
cord-017420-tjwxec77	187	12	in	in	IN
cord-017420-tjwxec77	187	13	patients	patient	NNS
cord-017420-tjwxec77	187	14	with	with	IN
cord-017420-tjwxec77	187	15	moderate	moderate	JJ
cord-017420-tjwxec77	187	16	to	to	IN
cord-017420-tjwxec77	187	17	severe	severe	JJ
cord-017420-tjwxec77	187	18	ARDS	ARDS	NNP
cord-017420-tjwxec77	187	19	(	(	-LRB-
cord-017420-tjwxec77	187	20	PaO2	pao2	NN
cord-017420-tjwxec77	187	21	:	:	:
cord-017420-tjwxec77	188	1	FiO2	FiO2	NNS
cord-017420-tjwxec77	188	2	<	<	XX
cord-017420-tjwxec77	188	3	150	150	CD
cord-017420-tjwxec77	188	4	)	)	-RRB-
cord-017420-tjwxec77	189	1	[	[	-LRB-
cord-017420-tjwxec77	189	2	32	32	CD
cord-017420-tjwxec77	189	3	,	,	,
cord-017420-tjwxec77	189	4	54	54	CD
cord-017420-tjwxec77	189	5	]	]	-RRB-
cord-017420-tjwxec77	189	6	.	.	.
cord-017420-tjwxec77	190	1	Mortality	mortality	NN
cord-017420-tjwxec77	190	2	for	for	IN
cord-017420-tjwxec77	190	3	patients	patient	NNS
cord-017420-tjwxec77	190	4	who	who	WP
cord-017420-tjwxec77	190	5	develop	develop	VBP
cord-017420-tjwxec77	190	6	ARDS	ARDS	NNP
cord-017420-tjwxec77	190	7	in	in	IN
cord-017420-tjwxec77	190	8	this	this	DT
cord-017420-tjwxec77	190	9	context	context	NN
cord-017420-tjwxec77	190	10	remains	remain	VBZ
cord-017420-tjwxec77	190	11	high	high	JJ
cord-017420-tjwxec77	190	12	,	,	,
cord-017420-tjwxec77	190	13	but	but	CC
cord-017420-tjwxec77	190	14	outcomes	outcome	NNS
cord-017420-tjwxec77	190	15	are	be	VBP
cord-017420-tjwxec77	190	16	improving	improve	VBG
cord-017420-tjwxec77	190	17	.	.	.
cord-017420-tjwxec77	191	1	Attention	attention	NN
cord-017420-tjwxec77	191	2	to	to	IN
cord-017420-tjwxec77	191	3	best	good	JJS
cord-017420-tjwxec77	191	4	practices	practice	NNS
cord-017420-tjwxec77	191	5	for	for	IN
cord-017420-tjwxec77	191	6	mechanical	mechanical	JJ
cord-017420-tjwxec77	191	7	ventilation	ventilation	NN
cord-017420-tjwxec77	191	8	is	be	VBZ
cord-017420-tjwxec77	191	9	essential	essential	JJ
cord-017420-tjwxec77	191	10	.	.	.
cord-017420-tjwxec77	192	1	An	an	DT
cord-017420-tjwxec77	192	2	algorithm	algorithm	NN
cord-017420-tjwxec77	192	3	for	for	IN
cord-017420-tjwxec77	192	4	the	the	DT
cord-017420-tjwxec77	192	5	empiric	empiric	JJ
cord-017420-tjwxec77	192	6	management	management	NN
cord-017420-tjwxec77	192	7	of	of	IN
cord-017420-tjwxec77	192	8	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	192	9	fever	fever	NN
cord-017420-tjwxec77	192	10	can	can	MD
cord-017420-tjwxec77	192	11	be	be	VB
cord-017420-tjwxec77	192	12	found	find	VBN
cord-017420-tjwxec77	192	13	in	in	IN
cord-017420-tjwxec77	192	14	Fig	Fig	NNP
cord-017420-tjwxec77	192	15	.	.	.
cord-017420-tjwxec77	193	1	1	1	LS
cord-017420-tjwxec77	193	2	.	.	.
cord-017420-tjwxec77	194	1	The	the	DT
cord-017420-tjwxec77	194	2	risk	risk	NN
cord-017420-tjwxec77	194	3	of	of	IN
cord-017420-tjwxec77	194	4	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	194	5	fever	fever	NN
cord-017420-tjwxec77	194	6	and	and	CC
cord-017420-tjwxec77	194	7	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	194	8	sepsis	sepsis	NN
cord-017420-tjwxec77	194	9	resolves	resolve	VBZ
cord-017420-tjwxec77	194	10	once	once	IN
cord-017420-tjwxec77	194	11	the	the	DT
cord-017420-tjwxec77	194	12	bone	bone	NN
cord-017420-tjwxec77	194	13	marrow	marrow	NN
cord-017420-tjwxec77	194	14	recovers	recover	VBZ
cord-017420-tjwxec77	194	15	and	and	CC
cord-017420-tjwxec77	194	16	neutrophil	neutrophil	NN
cord-017420-tjwxec77	194	17	counts	count	VBZ
cord-017420-tjwxec77	194	18	return	return	VBP
cord-017420-tjwxec77	194	19	to	to	IN
cord-017420-tjwxec77	194	20	normal	normal	JJ
cord-017420-tjwxec77	194	21	.	.	.
cord-017420-tjwxec77	195	1	If	if	IN
cord-017420-tjwxec77	195	2	treated	treat	VBN
cord-017420-tjwxec77	195	3	appropriately	appropriately	RB
cord-017420-tjwxec77	195	4	,	,	,
cord-017420-tjwxec77	195	5	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	195	6	fever	fever	NN
cord-017420-tjwxec77	195	7	is	be	VBZ
cord-017420-tjwxec77	195	8	a	a	DT
cord-017420-tjwxec77	195	9	common	common	JJ
cord-017420-tjwxec77	195	10	,	,	,
cord-017420-tjwxec77	195	11	predictable	predictable	JJ
cord-017420-tjwxec77	195	12	,	,	,
cord-017420-tjwxec77	195	13	and	and	CC
cord-017420-tjwxec77	195	14	manageable	manageable	JJ
cord-017420-tjwxec77	195	15	complication	complication	NN
cord-017420-tjwxec77	195	16	of	of	IN
cord-017420-tjwxec77	195	17	cytotoxic	cytotoxic	JJ
cord-017420-tjwxec77	195	18	therapy	therapy	NN
cord-017420-tjwxec77	195	19	or	or	CC
cord-017420-tjwxec77	195	20	HSCT	HSCT	NNP
cord-017420-tjwxec77	195	21	.	.	.
cord-017420-tjwxec77	196	1	Neutropenic	neutropenic	JJ
cord-017420-tjwxec77	196	2	sepsis	sepsis	NN
cord-017420-tjwxec77	196	3	continues	continue	VBZ
cord-017420-tjwxec77	196	4	to	to	TO
cord-017420-tjwxec77	196	5	confer	confer	VB
cord-017420-tjwxec77	196	6	a	a	DT
cord-017420-tjwxec77	196	7	poor	poor	JJ
cord-017420-tjwxec77	196	8	prognosis	prognosis	NN
cord-017420-tjwxec77	196	9	,	,	,
cord-017420-tjwxec77	196	10	with	with	IN
cord-017420-tjwxec77	196	11	recent	recent	JJ
cord-017420-tjwxec77	196	12	data	datum	NNS
cord-017420-tjwxec77	196	13	suggesting	suggest	VBG
cord-017420-tjwxec77	196	14	an	an	DT
cord-017420-tjwxec77	196	15	approximate	approximate	JJ
cord-017420-tjwxec77	196	16	46	46	CD
cord-017420-tjwxec77	196	17	%	%	NN
cord-017420-tjwxec77	196	18	mortality	mortality	NN
cord-017420-tjwxec77	196	19	rate	rate	NN
cord-017420-tjwxec77	196	20	in	in	IN
cord-017420-tjwxec77	196	21	patients	patient	NNS
cord-017420-tjwxec77	196	22	with	with	IN
cord-017420-tjwxec77	196	23	hematologic	hematologic	JJ
cord-017420-tjwxec77	196	24	malignancies	malignancy	NNS
cord-017420-tjwxec77	196	25	who	who	WP
cord-017420-tjwxec77	196	26	develop	develop	VBP
cord-017420-tjwxec77	196	27	septic	septic	JJ
cord-017420-tjwxec77	196	28	shock	shock	NN
cord-017420-tjwxec77	196	29	[	[	-LRB-
cord-017420-tjwxec77	196	30	7	7	CD
cord-017420-tjwxec77	196	31	,	,	,
cord-017420-tjwxec77	196	32	39	39	CD
cord-017420-tjwxec77	196	33	,	,	,
cord-017420-tjwxec77	196	34	47	47	CD
cord-017420-tjwxec77	196	35	]	]	-RRB-
cord-017420-tjwxec77	196	36	.	.	.
cord-017420-tjwxec77	197	1	Predictors	predictor	NNS
cord-017420-tjwxec77	197	2	of	of	IN
cord-017420-tjwxec77	197	3	mortality	mortality	NN
cord-017420-tjwxec77	197	4	include	include	VBP
cord-017420-tjwxec77	197	5	sepsis	sepsis	NN
cord-017420-tjwxec77	197	6	after	after	IN
cord-017420-tjwxec77	197	7	allogeneic	allogeneic	NN
cord-017420-tjwxec77	197	8	HSCT	HSCT	NNP
cord-017420-tjwxec77	197	9	,	,	,
cord-017420-tjwxec77	197	10	the	the	DT
cord-017420-tjwxec77	197	11	presence	presence	NN
cord-017420-tjwxec77	197	12	of	of	IN
cord-017420-tjwxec77	197	13	graft	graft	NN
cord-017420-tjwxec77	197	14	vs	vs	IN
cord-017420-tjwxec77	197	15	host	host	NN
cord-017420-tjwxec77	197	16	disease	disease	NN
cord-017420-tjwxec77	197	17	,	,	,
cord-017420-tjwxec77	197	18	respiratory	respiratory	JJ
cord-017420-tjwxec77	197	19	failure	failure	NN
cord-017420-tjwxec77	197	20	requiring	require	VBG
cord-017420-tjwxec77	197	21	mechanical	mechanical	JJ
cord-017420-tjwxec77	197	22	ventilation	ventilation	NN
cord-017420-tjwxec77	197	23	,	,	,
cord-017420-tjwxec77	197	24	positive	positive	JJ
cord-017420-tjwxec77	197	25	blood	blood	NN
cord-017420-tjwxec77	197	26	cultures	culture	NNS
cord-017420-tjwxec77	197	27	,	,	,
cord-017420-tjwxec77	197	28	cardiac	cardiac	JJ
cord-017420-tjwxec77	197	29	failure	failure	NN
cord-017420-tjwxec77	197	30	,	,	,
cord-017420-tjwxec77	197	31	renal	renal	JJ
cord-017420-tjwxec77	197	32	failure	failure	NN
cord-017420-tjwxec77	197	33	,	,	,
cord-017420-tjwxec77	197	34	and	and	CC
cord-017420-tjwxec77	197	35	hepatic	hepatic	JJ
cord-017420-tjwxec77	197	36	failure	failure	NN
cord-017420-tjwxec77	197	37	[	[	-LRB-
cord-017420-tjwxec77	197	38	38	38	CD
cord-017420-tjwxec77	197	39	,	,	,
cord-017420-tjwxec77	197	40	47	47	CD
cord-017420-tjwxec77	197	41	]	]	-RRB-
cord-017420-tjwxec77	197	42	.	.	.
cord-017420-tjwxec77	198	1	Younger	young	JJR
cord-017420-tjwxec77	198	2	age	age	NN
cord-017420-tjwxec77	198	3	(	(	-LRB-
cord-017420-tjwxec77	198	4	<	<	XX
cord-017420-tjwxec77	198	5	70	70	CD
cord-017420-tjwxec77	198	6	years	year	NNS
cord-017420-tjwxec77	198	7	)	)	-RRB-
cord-017420-tjwxec77	198	8	and	and	CC
cord-017420-tjwxec77	198	9	the	the	DT
cord-017420-tjwxec77	198	10	presence	presence	NN
cord-017420-tjwxec77	198	11	of	of	IN
cord-017420-tjwxec77	198	12	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	198	13	enterocolitis	enterocolitis	NN
cord-017420-tjwxec77	198	14	are	be	VBP
cord-017420-tjwxec77	198	15	associated	associate	VBN
cord-017420-tjwxec77	198	16	with	with	IN
cord-017420-tjwxec77	198	17	improved	improved	JJ
cord-017420-tjwxec77	198	18	survival	survival	NN
cord-017420-tjwxec77	198	19	[	[	-LRB-
cord-017420-tjwxec77	198	20	47	47	CD
cord-017420-tjwxec77	198	21	]	]	-RRB-
cord-017420-tjwxec77	198	22	.	.	.
cord-017420-tjwxec77	199	1	Encouragingly	encouragingly	RB
cord-017420-tjwxec77	199	2	,	,	,
cord-017420-tjwxec77	199	3	survival	survival	NN
cord-017420-tjwxec77	199	4	in	in	IN
cord-017420-tjwxec77	199	5	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	199	6	sepsis	sepsis	NN
cord-017420-tjwxec77	199	7	and	and	CC
cord-017420-tjwxec77	199	8	septic	septic	JJ
cord-017420-tjwxec77	199	9	shock	shock	NN
cord-017420-tjwxec77	199	10	appears	appear	VBZ
cord-017420-tjwxec77	199	11	to	to	TO
cord-017420-tjwxec77	199	12	be	be	VB
cord-017420-tjwxec77	199	13	improving	improve	VBG
cord-017420-tjwxec77	199	14	but	but	CC
cord-017420-tjwxec77	199	15	is	be	VBZ
cord-017420-tjwxec77	199	16	still	still	RB
cord-017420-tjwxec77	199	17	worse	bad	JJR
cord-017420-tjwxec77	199	18	than	than	IN
cord-017420-tjwxec77	199	19	in	in	IN
cord-017420-tjwxec77	199	20	non	non	JJ
cord-017420-tjwxec77	199	21	-	-	JJ
cord-017420-tjwxec77	199	22	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	199	23	septic	septic	JJ
cord-017420-tjwxec77	199	24	patients	patient	NNS
cord-017420-tjwxec77	199	25	[	[	-LRB-
cord-017420-tjwxec77	199	26	9	9	CD
cord-017420-tjwxec77	199	27	,	,	,
cord-017420-tjwxec77	199	28	10	10	CD
cord-017420-tjwxec77	199	29	,	,	,
cord-017420-tjwxec77	199	30	39	39	CD
cord-017420-tjwxec77	199	31	]	]	-RRB-
cord-017420-tjwxec77	199	32	.	.	.
cord-017420-tjwxec77	200	1	The	the	DT
cord-017420-tjwxec77	200	2	emergence	emergence	NN
cord-017420-tjwxec77	200	3	of	of	IN
cord-017420-tjwxec77	200	4	multidrug	multidrug	NN
cord-017420-tjwxec77	200	5	-	-	HYPH
cord-017420-tjwxec77	200	6	resistant	resistant	JJ
cord-017420-tjwxec77	200	7	organisms	organism	NNS
cord-017420-tjwxec77	200	8	is	be	VBZ
cord-017420-tjwxec77	200	9	a	a	DT
cord-017420-tjwxec77	200	10	major	major	JJ
cord-017420-tjwxec77	200	11	concern	concern	NN
cord-017420-tjwxec77	200	12	,	,	,
cord-017420-tjwxec77	200	13	and	and	CC
cord-017420-tjwxec77	200	14	there	there	EX
cord-017420-tjwxec77	200	15	is	be	VBZ
cord-017420-tjwxec77	200	16	an	an	DT
cord-017420-tjwxec77	200	17	urgent	urgent	JJ
cord-017420-tjwxec77	200	18	need	need	NN
cord-017420-tjwxec77	200	19	for	for	IN
cord-017420-tjwxec77	200	20	novel	novel	JJ
cord-017420-tjwxec77	200	21	antibiotics	antibiotic	NNS
cord-017420-tjwxec77	200	22	to	to	TO
cord-017420-tjwxec77	200	23	address	address	VB
cord-017420-tjwxec77	200	24	this	this	DT
cord-017420-tjwxec77	200	25	threat	threat	NN
cord-017420-tjwxec77	200	26	.	.	.
cord-017420-tjwxec77	201	1	Along	along	IN
cord-017420-tjwxec77	201	2	these	these	DT
cord-017420-tjwxec77	201	3	lines	line	NNS
cord-017420-tjwxec77	201	4	,	,	,
cord-017420-tjwxec77	201	5	additional	additional	JJ
cord-017420-tjwxec77	201	6	work	work	NN
cord-017420-tjwxec77	201	7	needs	need	VBZ
cord-017420-tjwxec77	201	8	to	to	TO
cord-017420-tjwxec77	201	9	be	be	VB
cord-017420-tjwxec77	201	10	done	do	VBN
cord-017420-tjwxec77	201	11	to	to	TO
cord-017420-tjwxec77	201	12	identify	identify	VB
cord-017420-tjwxec77	201	13	patients	patient	NNS
cord-017420-tjwxec77	201	14	in	in	IN
cord-017420-tjwxec77	201	15	whom	whom	WP
cord-017420-tjwxec77	201	16	antibiotic	antibiotic	JJ
cord-017420-tjwxec77	201	17	therapy	therapy	NN
cord-017420-tjwxec77	201	18	can	can	MD
cord-017420-tjwxec77	201	19	be	be	VB
cord-017420-tjwxec77	201	20	safely	safely	RB
cord-017420-tjwxec77	201	21	de	de	VBN
cord-017420-tjwxec77	201	22	-	-	VBN
cord-017420-tjwxec77	201	23	escalated	escalate	VBN
cord-017420-tjwxec77	201	24	.	.	.
cord-017420-tjwxec77	202	1	The	the	DT
cord-017420-tjwxec77	202	2	pathophysiology	pathophysiology	NN
cord-017420-tjwxec77	202	3	of	of	IN
cord-017420-tjwxec77	202	4	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	202	5	sepsis	sepsis	NN
cord-017420-tjwxec77	202	6	requires	require	VBZ
cord-017420-tjwxec77	202	7	further	further	JJ
cord-017420-tjwxec77	202	8	study	study	NN
cord-017420-tjwxec77	202	9	and	and	CC
cord-017420-tjwxec77	202	10	efforts	effort	NNS
cord-017420-tjwxec77	202	11	made	make	VBN
cord-017420-tjwxec77	202	12	to	to	TO
cord-017420-tjwxec77	202	13	facilitate	facilitate	VB
cord-017420-tjwxec77	202	14	earlier	early	JJR
cord-017420-tjwxec77	202	15	diagnosis	diagnosis	NN
cord-017420-tjwxec77	202	16	and	and	CC
cord-017420-tjwxec77	202	17	identification	identification	NN
cord-017420-tjwxec77	202	18	of	of	IN
cord-017420-tjwxec77	202	19	pathogens	pathogen	NNS
cord-017420-tjwxec77	202	20	in	in	IN
cord-017420-tjwxec77	202	21	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	202	22	patients	patient	NNS
cord-017420-tjwxec77	202	23	.	.	.
cord-017420-tjwxec77	203	1	Finally	finally	RB
cord-017420-tjwxec77	203	2	,	,	,
cord-017420-tjwxec77	203	3	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	203	4	sepsis	sepsis	NN
cord-017420-tjwxec77	203	5	should	should	MD
cord-017420-tjwxec77	203	6	be	be	VB
cord-017420-tjwxec77	203	7	studied	study	VBN
cord-017420-tjwxec77	203	8	as	as	IN
cord-017420-tjwxec77	203	9	a	a	DT
cord-017420-tjwxec77	203	10	specific	specific	JJ
cord-017420-tjwxec77	203	11	and	and	CC
cord-017420-tjwxec77	203	12	separate	separate	JJ
cord-017420-tjwxec77	203	13	entity	entity	NN
cord-017420-tjwxec77	203	14	from	from	IN
cord-017420-tjwxec77	203	15	"	"	``
cord-017420-tjwxec77	203	16	normal	normal	JJ
cord-017420-tjwxec77	203	17	"	"	''
cord-017420-tjwxec77	203	18	sepsis	sepsis	NN
cord-017420-tjwxec77	203	19	,	,	,
cord-017420-tjwxec77	203	20	and	and	CC
cord-017420-tjwxec77	203	21	efficacy	efficacy	NN
cord-017420-tjwxec77	203	22	of	of	IN
cord-017420-tjwxec77	203	23	interventions	intervention	NNS
cord-017420-tjwxec77	203	24	confirmed	confirm	VBN
cord-017420-tjwxec77	203	25	in	in	IN
cord-017420-tjwxec77	203	26	this	this	DT
cord-017420-tjwxec77	203	27	specific	specific	JJ
cord-017420-tjwxec77	203	28	population	population	NN
cord-017420-tjwxec77	203	29	.	.	.
cord-017420-tjwxec77	203	30	 	 	_SP
cord-017420-tjwxec77	204	1	Ventilation	ventilation	NN
cord-017420-tjwxec77	204	2	with	with	IN
cord-017420-tjwxec77	204	3	lower	low	JJR
cord-017420-tjwxec77	204	4	tidal	tidal	JJ
cord-017420-tjwxec77	204	5	volumes	volume	NNS
cord-017420-tjwxec77	204	6	as	as	IN
cord-017420-tjwxec77	204	7	compared	compare	VBN
cord-017420-tjwxec77	204	8	with	with	IN
cord-017420-tjwxec77	204	9	traditional	traditional	JJ
cord-017420-tjwxec77	204	10	tidal	tidal	JJ
cord-017420-tjwxec77	204	11	volumes	volume	NNS
cord-017420-tjwxec77	204	12	for	for	IN
cord-017420-tjwxec77	204	13	acute	acute	JJ
cord-017420-tjwxec77	204	14	lung	lung	NN
cord-017420-tjwxec77	204	15	injury	injury	NN
cord-017420-tjwxec77	204	16	and	and	CC
cord-017420-tjwxec77	204	17	the	the	DT
cord-017420-tjwxec77	204	18	acute	acute	JJ
cord-017420-tjwxec77	204	19	respiratory	respiratory	JJ
cord-017420-tjwxec77	204	20	distress	distress	NN
cord-017420-tjwxec77	204	21	syndrome	syndrome	NN
cord-017420-tjwxec77	204	22	Optimisation	Optimisation	NNP
cord-017420-tjwxec77	204	23	of	of	IN
cord-017420-tjwxec77	204	24	empirical	empirical	JJ
cord-017420-tjwxec77	204	25	antimicrobial	antimicrobial	JJ
cord-017420-tjwxec77	204	26	therapy	therapy	NN
cord-017420-tjwxec77	204	27	in	in	IN
cord-017420-tjwxec77	204	28	patients	patient	NNS
cord-017420-tjwxec77	204	29	with	with	IN
cord-017420-tjwxec77	204	30	haematological	haematological	JJ
cord-017420-tjwxec77	204	31	malignancies	malignancy	NNS
cord-017420-tjwxec77	204	32	and	and	CC
cord-017420-tjwxec77	204	33	febrile	febrile	JJ
cord-017420-tjwxec77	204	34	neutropenia	neutropenia	NN
cord-017420-tjwxec77	204	35	(	(	-LRB-
cord-017420-tjwxec77	204	36	how	how	WRB
cord-017420-tjwxec77	204	37	long	long	JJ
cord-017420-tjwxec77	204	38	study	study	NN
cord-017420-tjwxec77	204	39	)	)	-RRB-
cord-017420-tjwxec77	204	40	:	:	:
cord-017420-tjwxec77	204	41	an	an	DT
cord-017420-tjwxec77	204	42	open	open	JJ
cord-017420-tjwxec77	204	43	-	-	HYPH
cord-017420-tjwxec77	204	44	label	label	NN
cord-017420-tjwxec77	204	45	,	,	,
cord-017420-tjwxec77	204	46	randomised	randomised	JJ
cord-017420-tjwxec77	204	47	,	,	,
cord-017420-tjwxec77	204	48	controlled	control	VBN
cord-017420-tjwxec77	204	49	phase	phase	NN
cord-017420-tjwxec77	204	50	4	4	CD
cord-017420-tjwxec77	204	51	trial	trial	NN
cord-017420-tjwxec77	204	52	Early	early	JJ
cord-017420-tjwxec77	204	53	vancomycin	vancomycin	NN
cord-017420-tjwxec77	204	54	-	-	HYPH
cord-017420-tjwxec77	204	55	resistant	resistant	JJ
cord-017420-tjwxec77	204	56	enterococcus	enterococcus	NN
cord-017420-tjwxec77	204	57	(	(	-LRB-
cord-017420-tjwxec77	204	58	VRE	VRE	NNP
cord-017420-tjwxec77	204	59	)	)	-RRB-
cord-017420-tjwxec77	204	60	bacteremia	bacteremia	NN
cord-017420-tjwxec77	204	61	after	after	IN
cord-017420-tjwxec77	204	62	allogeneic	allogeneic	NN
cord-017420-tjwxec77	204	63	bone	bone	NN
cord-017420-tjwxec77	204	64	marrow	marrow	NN
cord-017420-tjwxec77	204	65	transplantation	transplantation	NN
cord-017420-tjwxec77	204	66	is	be	VBZ
cord-017420-tjwxec77	204	67	associated	associate	VBN
cord-017420-tjwxec77	204	68	with	with	IN
cord-017420-tjwxec77	204	69	a	a	DT
cord-017420-tjwxec77	204	70	rapidly	rapidly	RB
cord-017420-tjwxec77	204	71	deteriorating	deteriorate	VBG
cord-017420-tjwxec77	204	72	clinical	clinical	JJ
cord-017420-tjwxec77	204	73	course	course	NN
cord-017420-tjwxec77	204	74	Acute	acute	JJ
cord-017420-tjwxec77	204	75	respiratory	respiratory	JJ
cord-017420-tjwxec77	204	76	distress	distress	NN
cord-017420-tjwxec77	204	77	syndrome	syndrome	NN
cord-017420-tjwxec77	204	78	during	during	IN
cord-017420-tjwxec77	204	79	neutropenia	neutropenia	NN
cord-017420-tjwxec77	204	80	recovery	recovery	NN
cord-017420-tjwxec77	204	81	Acute	acute	JJ
cord-017420-tjwxec77	204	82	respiratory	respiratory	JJ
cord-017420-tjwxec77	204	83	distress	distress	NN
cord-017420-tjwxec77	204	84	syndrome	syndrome	NN
cord-017420-tjwxec77	204	85	in	in	IN
cord-017420-tjwxec77	204	86	patients	patient	NNS
cord-017420-tjwxec77	204	87	with	with	IN
cord-017420-tjwxec77	204	88	malignancies	malignancy	NNS
cord-017420-tjwxec77	204	89	Diagnostic	diagnostic	JJ
cord-017420-tjwxec77	204	90	strategy	strategy	NN
cord-017420-tjwxec77	204	91	for	for	IN
cord-017420-tjwxec77	204	92	hematology	hematology	NN
cord-017420-tjwxec77	204	93	and	and	CC
cord-017420-tjwxec77	204	94	oncology	oncology	NN
cord-017420-tjwxec77	204	95	patients	patient	NNS
cord-017420-tjwxec77	204	96	with	with	IN
cord-017420-tjwxec77	204	97	acute	acute	JJ
cord-017420-tjwxec77	204	98	respiratory	respiratory	JJ
cord-017420-tjwxec77	204	99	failure	failure	NN
cord-017420-tjwxec77	204	100	:	:	:
cord-017420-tjwxec77	204	101	randomized	randomize	VBN
cord-017420-tjwxec77	204	102	controlled	control	VBN
cord-017420-tjwxec77	204	103	trial	trial	NN
cord-017420-tjwxec77	204	104	Outcomes	outcome	NNS
cord-017420-tjwxec77	204	105	of	of	IN
cord-017420-tjwxec77	204	106	critically	critically	RB
cord-017420-tjwxec77	204	107	ill	ill	JJ
cord-017420-tjwxec77	204	108	patients	patient	NNS
cord-017420-tjwxec77	204	109	with	with	IN
cord-017420-tjwxec77	204	110	hematologic	hematologic	JJ
cord-017420-tjwxec77	204	111	malignancies	malignancy	NNS
cord-017420-tjwxec77	204	112	:	:	:
cord-017420-tjwxec77	204	113	prospective	prospective	JJ
cord-017420-tjwxec77	204	114	multicenter	multicenter	JJ
cord-017420-tjwxec77	204	115	data	datum	NNS
cord-017420-tjwxec77	204	116	from	from	IN
cord-017420-tjwxec77	204	117	France	France	NNP
cord-017420-tjwxec77	204	118	and	and	CC
cord-017420-tjwxec77	204	119	Belgium	Belgium	NNP
cord-017420-tjwxec77	205	1	-a	-a	:
cord-017420-tjwxec77	206	1	groupe	groupe	NNP
cord-017420-tjwxec77	206	2	de	de	FW
cord-017420-tjwxec77	206	3	recherche	recherche	FW
cord-017420-tjwxec77	206	4	respiratoire	respiratoire	NNP
cord-017420-tjwxec77	206	5	en	en	NNP
cord-017420-tjwxec77	207	1	reanimation	reanimation	NNP
cord-017420-tjwxec77	207	2	onco	onco	NNP
cord-017420-tjwxec77	207	3	-	-	HYPH
cord-017420-tjwxec77	207	4	hematologique	hematologique	NN
cord-017420-tjwxec77	207	5	study	study	NN
cord-017420-tjwxec77	207	6	Diagnostic	diagnostic	JJ
cord-017420-tjwxec77	207	7	bronchoscopy	bronchoscopy	NN
cord-017420-tjwxec77	207	8	in	in	IN
cord-017420-tjwxec77	207	9	hematology	hematology	NN
cord-017420-tjwxec77	207	10	and	and	CC
cord-017420-tjwxec77	207	11	oncology	oncology	NN
cord-017420-tjwxec77	207	12	patients	patient	NNS
cord-017420-tjwxec77	207	13	with	with	IN
cord-017420-tjwxec77	207	14	acute	acute	JJ
cord-017420-tjwxec77	207	15	respiratory	respiratory	JJ
cord-017420-tjwxec77	207	16	failure	failure	NN
cord-017420-tjwxec77	207	17	:	:	:
cord-017420-tjwxec77	208	1	prospective	prospective	JJ
cord-017420-tjwxec77	208	2	multicenter	multicenter	JJ
cord-017420-tjwxec77	208	3	data	datum	NNS
cord-017420-tjwxec77	208	4	Groupe	Groupe	NNP
cord-017420-tjwxec77	208	5	de	de	FW
cord-017420-tjwxec77	208	6	Recherche	Recherche	NNP
cord-017420-tjwxec77	208	7	Respiratoire	Respiratoire	NNP
cord-017420-tjwxec77	208	8	en	en	IN
cord-017420-tjwxec77	208	9	Reanimation	Reanimation	NNP
cord-017420-tjwxec77	208	10	,	,	,
cord-017420-tjwxec77	208	11	O.-H.	O.-H.	NNP
cord-017420-tjwxec77	209	1	Managing	manage	VBG
cord-017420-tjwxec77	209	2	critically	critically	RB
cord-017420-tjwxec77	209	3	ill	ill	JJ
cord-017420-tjwxec77	209	4	hematology	hematology	NN
cord-017420-tjwxec77	209	5	patients	patient	NNS
cord-017420-tjwxec77	209	6	:	:	:
cord-017420-tjwxec77	209	7	time	time	NN
cord-017420-tjwxec77	209	8	to	to	TO
cord-017420-tjwxec77	209	9	think	think	VB
cord-017420-tjwxec77	209	10	differently	differently	RB
cord-017420-tjwxec77	209	11	The	the	DT
cord-017420-tjwxec77	209	12	intensive	intensive	JJ
cord-017420-tjwxec77	209	13	care	care	NN
cord-017420-tjwxec77	209	14	medicine	medicine	NN
cord-017420-tjwxec77	209	15	research	research	NN
cord-017420-tjwxec77	209	16	agenda	agenda	NN
cord-017420-tjwxec77	209	17	on	on	IN
cord-017420-tjwxec77	209	18	critically	critically	RB
cord-017420-tjwxec77	209	19	ill	ill	JJ
cord-017420-tjwxec77	209	20	oncology	oncology	NN
cord-017420-tjwxec77	209	21	and	and	CC
cord-017420-tjwxec77	209	22	hematology	hematology	NN
cord-017420-tjwxec77	209	23	patients	patient	NNS
cord-017420-tjwxec77	209	24	Kinetics	Kinetics	NNP
cord-017420-tjwxec77	209	25	of	of	IN
cord-017420-tjwxec77	209	26	engraftment	engraftment	NN
cord-017420-tjwxec77	209	27	following	follow	VBG
cord-017420-tjwxec77	209	28	allogeneic	allogeneic	IN
cord-017420-tjwxec77	209	29	hematopoietic	hematopoietic	JJ
cord-017420-tjwxec77	209	30	cell	cell	NN
cord-017420-tjwxec77	209	31	transplantation	transplantation	NN
cord-017420-tjwxec77	209	32	with	with	IN
cord-017420-tjwxec77	209	33	reduced	reduce	VBN
cord-017420-tjwxec77	209	34	-	-	HYPH
cord-017420-tjwxec77	209	35	intensity	intensity	NN
cord-017420-tjwxec77	209	36	or	or	CC
cord-017420-tjwxec77	209	37	nonmyeloablative	nonmyeloablative	JJ
cord-017420-tjwxec77	209	38	conditioning	conditioning	NN
cord-017420-tjwxec77	209	39	Impaired	impair	VBN
cord-017420-tjwxec77	209	40	lung	lung	NN
cord-017420-tjwxec77	209	41	repair	repair	NN
cord-017420-tjwxec77	209	42	during	during	IN
cord-017420-tjwxec77	209	43	neutropenia	neutropenia	NN
cord-017420-tjwxec77	209	44	can	can	MD
cord-017420-tjwxec77	209	45	be	be	VB
cord-017420-tjwxec77	209	46	reverted	revert	VBN
cord-017420-tjwxec77	209	47	by	by	IN
cord-017420-tjwxec77	209	48	matrix	matrix	NN
cord-017420-tjwxec77	209	49	metalloproteinase-9	metalloproteinase-9	NNP
cord-017420-tjwxec77	209	50	Mucosal	Mucosal	NNP
cord-017420-tjwxec77	209	51	barrier	barrier	NN
cord-017420-tjwxec77	209	52	injury	injury	NN
cord-017420-tjwxec77	209	53	:	:	:
cord-017420-tjwxec77	209	54	biology	biology	NN
cord-017420-tjwxec77	209	55	,	,	,
cord-017420-tjwxec77	209	56	pathology	pathology	NN
cord-017420-tjwxec77	209	57	,	,	,
cord-017420-tjwxec77	209	58	clinical	clinical	JJ
cord-017420-tjwxec77	209	59	counterparts	counterpart	NNS
cord-017420-tjwxec77	209	60	and	and	CC
cord-017420-tjwxec77	209	61	consequences	consequence	NNS
cord-017420-tjwxec77	209	62	of	of	IN
cord-017420-tjwxec77	209	63	intensive	intensive	JJ
cord-017420-tjwxec77	209	64	treatment	treatment	NN
cord-017420-tjwxec77	209	65	for	for	IN
cord-017420-tjwxec77	209	66	haematological	haematological	JJ
cord-017420-tjwxec77	209	67	malignancy	malignancy	NN
cord-017420-tjwxec77	209	68	:	:	:
cord-017420-tjwxec77	209	69	an	an	DT
cord-017420-tjwxec77	209	70	overview	overview	NN
cord-017420-tjwxec77	209	71	Inflammatory	inflammatory	JJ
cord-017420-tjwxec77	209	72	response	response	NN
cord-017420-tjwxec77	209	73	to	to	IN
cord-017420-tjwxec77	209	74	mucosal	mucosal	JJ
cord-017420-tjwxec77	209	75	barrier	barrier	NN
cord-017420-tjwxec77	209	76	injury	injury	NN
cord-017420-tjwxec77	209	77	after	after	IN
cord-017420-tjwxec77	209	78	myeloablative	myeloablative	NNP
cord-017420-tjwxec77	209	79	therapy	therapy	NN
cord-017420-tjwxec77	209	80	in	in	IN
cord-017420-tjwxec77	209	81	allogeneic	allogeneic	NN
cord-017420-tjwxec77	209	82	stem	stem	NN
cord-017420-tjwxec77	209	83	cell	cell	NN
cord-017420-tjwxec77	209	84	transplant	transplant	NN
cord-017420-tjwxec77	209	85	recipients	recipient	NNS
cord-017420-tjwxec77	209	86	Failure	failure	NN
cord-017420-tjwxec77	209	87	of	of	IN
cord-017420-tjwxec77	209	88	noninvasive	noninvasive	JJ
cord-017420-tjwxec77	209	89	ventilation	ventilation	NN
cord-017420-tjwxec77	209	90	for	for	IN
cord-017420-tjwxec77	209	91	de	de	NNP
cord-017420-tjwxec77	209	92	novo	novo	NNP
cord-017420-tjwxec77	209	93	acute	acute	JJ
cord-017420-tjwxec77	209	94	hypoxemic	hypoxemic	JJ
cord-017420-tjwxec77	209	95	respiratory	respiratory	JJ
cord-017420-tjwxec77	209	96	failure	failure	NN
cord-017420-tjwxec77	209	97	:	:	:
cord-017420-tjwxec77	209	98	role	role	NN
cord-017420-tjwxec77	209	99	of	of	IN
cord-017420-tjwxec77	209	100	tidal	tidal	JJ
cord-017420-tjwxec77	209	101	volume	volume	NN
cord-017420-tjwxec77	209	102	Platelet	platelet	NN
cord-017420-tjwxec77	209	103	TLR4	TLR4	NNP
cord-017420-tjwxec77	209	104	activates	activate	VBZ
cord-017420-tjwxec77	209	105	neutrophil	neutrophil	NN
cord-017420-tjwxec77	209	106	extracellular	extracellular	JJ
cord-017420-tjwxec77	209	107	traps	trap	NNS
cord-017420-tjwxec77	209	108	to	to	TO
cord-017420-tjwxec77	209	109	ensnare	ensnare	VB
cord-017420-tjwxec77	209	110	bacteria	bacteria	NNS
cord-017420-tjwxec77	209	111	in	in	IN
cord-017420-tjwxec77	209	112	septic	septic	JJ
cord-017420-tjwxec77	209	113	blood	blood	NN
cord-017420-tjwxec77	210	1	The	the	DT
cord-017420-tjwxec77	210	2	signs	sign	NNS
cord-017420-tjwxec77	210	3	,	,	,
cord-017420-tjwxec77	210	4	symptoms	symptom	NNS
cord-017420-tjwxec77	210	5	and	and	CC
cord-017420-tjwxec77	210	6	helpseeking	helpseeke	VBG
cord-017420-tjwxec77	210	7	experiences	experience	NNS
cord-017420-tjwxec77	210	8	of	of	IN
cord-017420-tjwxec77	210	9	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	210	10	sepsis	sepsis	NN
cord-017420-tjwxec77	210	11	patients	patient	NNS
cord-017420-tjwxec77	210	12	before	before	IN
cord-017420-tjwxec77	210	13	they	-PRON-	PRP
cord-017420-tjwxec77	210	14	reach	reach	VBP
cord-017420-tjwxec77	210	15	hospital	hospital	NN
cord-017420-tjwxec77	210	16	:	:	:
cord-017420-tjwxec77	210	17	a	a	DT
cord-017420-tjwxec77	210	18	qualitative	qualitative	JJ
cord-017420-tjwxec77	210	19	study	study	NN
cord-017420-tjwxec77	210	20	Risk	risk	NN
cord-017420-tjwxec77	210	21	Stratification	stratification	NN
cord-017420-tjwxec77	210	22	of	of	IN
cord-017420-tjwxec77	210	23	Sepsis	Sepsis	NNP
cord-017420-tjwxec77	210	24	,	,	,
cord-017420-tjwxec77	210	25	C.	C.	NNP
cord-017420-tjwxec77	210	26	Thrombocytopenia	Thrombocytopenia	NNP
cord-017420-tjwxec77	210	27	is	be	VBZ
cord-017420-tjwxec77	210	28	associated	associate	VBN
cord-017420-tjwxec77	210	29	with	with	IN
cord-017420-tjwxec77	210	30	a	a	DT
cord-017420-tjwxec77	210	31	dysregulated	dysregulate	VBN
cord-017420-tjwxec77	210	32	host	host	NN
cord-017420-tjwxec77	210	33	response	response	NN
cord-017420-tjwxec77	210	34	in	in	IN
cord-017420-tjwxec77	210	35	critically	critically	RB
cord-017420-tjwxec77	210	36	ill	ill	JJ
cord-017420-tjwxec77	210	37	sepsis	sepsis	NN
cord-017420-tjwxec77	210	38	patients	patient	NNS
cord-017420-tjwxec77	210	39	Bronchoalveolar	Bronchoalveolar	NNP
cord-017420-tjwxec77	210	40	lavage	lavage	NN
cord-017420-tjwxec77	210	41	during	during	IN
cord-017420-tjwxec77	210	42	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	210	43	episodes	episode	NNS
cord-017420-tjwxec77	210	44	:	:	:
cord-017420-tjwxec77	210	45	diagnostic	diagnostic	JJ
cord-017420-tjwxec77	210	46	yield	yield	NN
cord-017420-tjwxec77	210	47	and	and	CC
cord-017420-tjwxec77	210	48	cellular	cellular	JJ
cord-017420-tjwxec77	210	49	pattern	pattern	NN
cord-017420-tjwxec77	210	50	Role	role	NN
cord-017420-tjwxec77	210	51	of	of	IN
cord-017420-tjwxec77	210	52	circulating	circulate	VBG
cord-017420-tjwxec77	210	53	lymphocytes	lymphocyte	NNS
cord-017420-tjwxec77	210	54	in	in	IN
cord-017420-tjwxec77	210	55	patients	patient	NNS
cord-017420-tjwxec77	210	56	with	with	IN
cord-017420-tjwxec77	210	57	sepsis	sepsis	NN
cord-017420-tjwxec77	210	58	Thrombocytopenia	Thrombocytopenia	NNP
cord-017420-tjwxec77	210	59	impairs	impair	VBZ
cord-017420-tjwxec77	210	60	host	host	NN
cord-017420-tjwxec77	210	61	defense	defense	NN
cord-017420-tjwxec77	210	62	in	in	IN
cord-017420-tjwxec77	210	63	gramnegative	gramnegative	NNP
cord-017420-tjwxec77	210	64	pneumonia	pneumonia	NN
cord-017420-tjwxec77	210	65	-	-	HYPH
cord-017420-tjwxec77	210	66	derived	derive	VBN
cord-017420-tjwxec77	210	67	sepsis	sepsis	NN
cord-017420-tjwxec77	210	68	in	in	IN
cord-017420-tjwxec77	210	69	mice	mouse	NNS
cord-017420-tjwxec77	211	1	Meta	Meta	NNP
cord-017420-tjwxec77	211	2	-	-	HYPH
cord-017420-tjwxec77	211	3	analysis	analysis	NN
cord-017420-tjwxec77	211	4	of	of	IN
cord-017420-tjwxec77	211	5	randomized	randomized	JJ
cord-017420-tjwxec77	211	6	controlled	control	VBN
cord-017420-tjwxec77	211	7	trials	trial	NNS
cord-017420-tjwxec77	211	8	of	of	IN
cord-017420-tjwxec77	211	9	prophylactic	prophylactic	JJ
cord-017420-tjwxec77	211	10	granulocyte	granulocyte	NN
cord-017420-tjwxec77	211	11	colony	colony	NN
cord-017420-tjwxec77	211	12	-	-	HYPH
cord-017420-tjwxec77	211	13	stimulating	stimulate	VBG
cord-017420-tjwxec77	211	14	factor	factor	NN
cord-017420-tjwxec77	211	15	and	and	CC
cord-017420-tjwxec77	211	16	granulocyte	granulocyte	NN
cord-017420-tjwxec77	211	17	-	-	HYPH
cord-017420-tjwxec77	211	18	macrophage	macrophage	NN
cord-017420-tjwxec77	211	19	colony	colony	NN
cord-017420-tjwxec77	211	20	-	-	HYPH
cord-017420-tjwxec77	211	21	stimulating	stimulate	VBG
cord-017420-tjwxec77	211	22	factor	factor	NN
cord-017420-tjwxec77	211	23	after	after	IN
cord-017420-tjwxec77	211	24	autologous	autologous	JJ
cord-017420-tjwxec77	211	25	and	and	CC
cord-017420-tjwxec77	211	26	allogeneic	allogeneic	IN
cord-017420-tjwxec77	211	27	stem	stem	NN
cord-017420-tjwxec77	211	28	cell	cell	NN
cord-017420-tjwxec77	211	29	transplantation	transplantation	NN
cord-017420-tjwxec77	211	30	Blood	blood	NN
cord-017420-tjwxec77	211	31	platelets	platelet	NNS
cord-017420-tjwxec77	211	32	and	and	CC
cord-017420-tjwxec77	211	33	sepsis	sepsis	NN
cord-017420-tjwxec77	211	34	pathophysiology	pathophysiology	NN
cord-017420-tjwxec77	211	35	:	:	:
cord-017420-tjwxec77	211	36	a	a	DT
cord-017420-tjwxec77	211	37	new	new	JJ
cord-017420-tjwxec77	211	38	therapeutic	therapeutic	JJ
cord-017420-tjwxec77	211	39	prospect	prospect	NN
cord-017420-tjwxec77	211	40	in	in	IN
cord-017420-tjwxec77	211	41	critical	critical	JJ
cord-017420-tjwxec77	211	42	ill	ill	JJ
cord-017420-tjwxec77	211	43	patients	patient	NNS
cord-017420-tjwxec77	211	44	?	?	.
cord-017420-tjwxec77	212	1	Ann	Ann	NNP
cord-017420-tjwxec77	212	2	Intensive	Intensive	NNP
cord-017420-tjwxec77	212	3	Care	Care	NNP
cord-017420-tjwxec77	212	4	Granulocyte	Granulocyte	NNP
cord-017420-tjwxec77	212	5	transfusions	transfusion	NNS
cord-017420-tjwxec77	212	6	for	for	IN
cord-017420-tjwxec77	212	7	preventing	prevent	VBG
cord-017420-tjwxec77	212	8	infections	infection	NNS
cord-017420-tjwxec77	212	9	in	in	IN
cord-017420-tjwxec77	212	10	people	people	NNS
cord-017420-tjwxec77	212	11	with	with	IN
cord-017420-tjwxec77	212	12	neutropenia	neutropenia	NN
cord-017420-tjwxec77	212	13	or	or	CC
cord-017420-tjwxec77	212	14	neutrophil	neutrophil	NN
cord-017420-tjwxec77	212	15	dysfunction	dysfunction	NN
cord-017420-tjwxec77	212	16	Granulocyte	Granulocyte	NNP
cord-017420-tjwxec77	212	17	transfusions	transfusion	NNS
cord-017420-tjwxec77	212	18	for	for	IN
cord-017420-tjwxec77	212	19	treating	treat	VBG
cord-017420-tjwxec77	212	20	infections	infection	NNS
cord-017420-tjwxec77	212	21	in	in	IN
cord-017420-tjwxec77	212	22	people	people	NNS
cord-017420-tjwxec77	212	23	with	with	IN
cord-017420-tjwxec77	212	24	neutropenia	neutropenia	NN
cord-017420-tjwxec77	212	25	or	or	CC
cord-017420-tjwxec77	212	26	neutrophil	neutrophil	NN
cord-017420-tjwxec77	212	27	dysfunction	dysfunction	NN
cord-017420-tjwxec77	212	28	Clinical	clinical	JJ
cord-017420-tjwxec77	212	29	impact	impact	NN
cord-017420-tjwxec77	212	30	of	of	IN
cord-017420-tjwxec77	212	31	pretransplant	pretransplant	JJ
cord-017420-tjwxec77	212	32	multidrug	multidrug	NN
cord-017420-tjwxec77	212	33	-	-	HYPH
cord-017420-tjwxec77	212	34	resistant	resistant	JJ
cord-017420-tjwxec77	212	35	gram	gram	NN
cord-017420-tjwxec77	212	36	-	-	HYPH
cord-017420-tjwxec77	212	37	negative	negative	JJ
cord-017420-tjwxec77	212	38	colonization	colonization	NN
cord-017420-tjwxec77	212	39	in	in	IN
cord-017420-tjwxec77	212	40	autologous	autologous	JJ
cord-017420-tjwxec77	212	41	and	and	CC
cord-017420-tjwxec77	212	42	allogeneic	allogeneic	IN
cord-017420-tjwxec77	212	43	hematopoietic	hematopoietic	JJ
cord-017420-tjwxec77	212	44	stem	stem	NN
cord-017420-tjwxec77	212	45	cell	cell	NN
cord-017420-tjwxec77	212	46	transplantation	transplantation	NN
cord-017420-tjwxec77	213	1	Highflow	Highflow	NNP
cord-017420-tjwxec77	213	2	oxygen	oxygen	NN
cord-017420-tjwxec77	213	3	through	through	IN
cord-017420-tjwxec77	213	4	nasal	nasal	NN
cord-017420-tjwxec77	213	5	cannula	cannula	NN
cord-017420-tjwxec77	213	6	in	in	IN
cord-017420-tjwxec77	213	7	acute	acute	JJ
cord-017420-tjwxec77	213	8	hypoxemic	hypoxemic	JJ
cord-017420-tjwxec77	213	9	respiratory	respiratory	JJ
cord-017420-tjwxec77	213	10	failure	failure	NN
cord-017420-tjwxec77	213	11	Infectious	Infectious	NNP
cord-017420-tjwxec77	213	12	Diseases	Diseases	NNPS
cord-017420-tjwxec77	213	13	Society	Society	NNP
cord-017420-tjwxec77	213	14	of	of	IN
cord-017420-tjwxec77	213	15	,	,	,
cord-017420-tjwxec77	213	16	A.	A.	NNP
cord-017420-tjwxec77	213	17	Clinical	clinical	JJ
cord-017420-tjwxec77	213	18	practice	practice	NN
cord-017420-tjwxec77	213	19	guideline	guideline	NN
cord-017420-tjwxec77	213	20	for	for	IN
cord-017420-tjwxec77	213	21	the	the	DT
cord-017420-tjwxec77	213	22	use	use	NN
cord-017420-tjwxec77	213	23	of	of	IN
cord-017420-tjwxec77	213	24	antimicrobial	antimicrobial	JJ
cord-017420-tjwxec77	213	25	agents	agent	NNS
cord-017420-tjwxec77	213	26	in	in	IN
cord-017420-tjwxec77	213	27	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	213	28	patients	patient	NNS
cord-017420-tjwxec77	213	29	with	with	IN
cord-017420-tjwxec77	213	30	cancer	cancer	NN
cord-017420-tjwxec77	213	31	:	:	:
cord-017420-tjwxec77	214	1	2010	2010	CD
cord-017420-tjwxec77	214	2	update	update	NN
cord-017420-tjwxec77	214	3	by	by	IN
cord-017420-tjwxec77	214	4	the	the	DT
cord-017420-tjwxec77	214	5	Infectious	Infectious	NNP
cord-017420-tjwxec77	214	6	Diseases	Diseases	NNPS
cord-017420-tjwxec77	214	7	Society	Society	NNP
cord-017420-tjwxec77	214	8	of	of	IN
cord-017420-tjwxec77	214	9	America	America	NNP
cord-017420-tjwxec77	214	10	Infectious	Infectious	NNP
cord-017420-tjwxec77	214	11	Diseases	Diseases	NNPS
cord-017420-tjwxec77	214	12	Society	Society	NNP
cord-017420-tjwxec77	214	13	of	of	IN
cord-017420-tjwxec77	214	14	,	,	,
cord-017420-tjwxec77	214	15	A.	A.	NNP
cord-017420-tjwxec77	214	16	Clinical	clinical	JJ
cord-017420-tjwxec77	214	17	practice	practice	NN
cord-017420-tjwxec77	214	18	guideline	guideline	NN
cord-017420-tjwxec77	214	19	for	for	IN
cord-017420-tjwxec77	214	20	the	the	DT
cord-017420-tjwxec77	214	21	use	use	NN
cord-017420-tjwxec77	214	22	of	of	IN
cord-017420-tjwxec77	214	23	antimicrobial	antimicrobial	JJ
cord-017420-tjwxec77	214	24	agents	agent	NNS
cord-017420-tjwxec77	214	25	in	in	IN
cord-017420-tjwxec77	214	26	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	214	27	patients	patient	NNS
cord-017420-tjwxec77	214	28	with	with	IN
cord-017420-tjwxec77	214	29	cancer	cancer	NN
cord-017420-tjwxec77	214	30	:	:	:
cord-017420-tjwxec77	215	1	2010	2010	CD
cord-017420-tjwxec77	215	2	update	update	NN
cord-017420-tjwxec77	215	3	by	by	IN
cord-017420-tjwxec77	215	4	the	the	DT
cord-017420-tjwxec77	215	5	Infectious	Infectious	NNP
cord-017420-tjwxec77	215	6	Diseases	Diseases	NNPS
cord-017420-tjwxec77	215	7	Society	Society	NNP
cord-017420-tjwxec77	215	8	of	of	IN
cord-017420-tjwxec77	215	9	America	America	NNP
cord-017420-tjwxec77	215	10	Antibiotic	antibiotic	JJ
cord-017420-tjwxec77	215	11	prophylaxis	prophylaxis	NN
cord-017420-tjwxec77	215	12	for	for	IN
cord-017420-tjwxec77	215	13	bacterial	bacterial	JJ
cord-017420-tjwxec77	215	14	infections	infection	NNS
cord-017420-tjwxec77	215	15	in	in	IN
cord-017420-tjwxec77	215	16	afebrile	afebrile	JJ
cord-017420-tjwxec77	215	17	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	215	18	patients	patient	NNS
cord-017420-tjwxec77	215	19	following	follow	VBG
cord-017420-tjwxec77	215	20	chemotherapy	chemotherapy	NN
cord-017420-tjwxec77	215	21	Neutropenic	Neutropenic	NNP
cord-017420-tjwxec77	215	22	enterocolitis	enterocolitis	NN
cord-017420-tjwxec77	215	23	in	in	IN
cord-017420-tjwxec77	215	24	adults	adult	NNS
cord-017420-tjwxec77	215	25	:	:	:
cord-017420-tjwxec77	215	26	systematic	systematic	JJ
cord-017420-tjwxec77	215	27	analysis	analysis	NN
cord-017420-tjwxec77	215	28	of	of	IN
cord-017420-tjwxec77	215	29	evidence	evidence	NN
cord-017420-tjwxec77	215	30	quality	quality	NN
cord-017420-tjwxec77	215	31	Prone	prone	JJ
cord-017420-tjwxec77	215	32	positioning	positioning	NN
cord-017420-tjwxec77	215	33	in	in	IN
cord-017420-tjwxec77	215	34	severe	severe	JJ
cord-017420-tjwxec77	215	35	acute	acute	JJ
cord-017420-tjwxec77	215	36	respiratory	respiratory	JJ
cord-017420-tjwxec77	215	37	distress	distress	NN
cord-017420-tjwxec77	215	38	syndrome	syndrome	NN
cord-017420-tjwxec77	215	39	Diagnosis	diagnosis	NN
cord-017420-tjwxec77	215	40	and	and	CC
cord-017420-tjwxec77	215	41	empirical	empirical	JJ
cord-017420-tjwxec77	215	42	treatment	treatment	NN
cord-017420-tjwxec77	215	43	of	of	IN
cord-017420-tjwxec77	215	44	fever	fever	NN
cord-017420-tjwxec77	215	45	of	of	IN
cord-017420-tjwxec77	215	46	unknown	unknown	JJ
cord-017420-tjwxec77	215	47	origin	origin	NN
cord-017420-tjwxec77	215	48	(	(	-LRB-
cord-017420-tjwxec77	215	49	FUO	fuo	NN
cord-017420-tjwxec77	215	50	)	)	-RRB-
cord-017420-tjwxec77	215	51	in	in	IN
cord-017420-tjwxec77	215	52	adult	adult	NN
cord-017420-tjwxec77	215	53	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	215	54	patients	patient	NNS
cord-017420-tjwxec77	215	55	:	:	:
cord-017420-tjwxec77	215	56	guidelines	guideline	NNS
cord-017420-tjwxec77	215	57	of	of	IN
cord-017420-tjwxec77	215	58	the	the	DT
cord-017420-tjwxec77	215	59	Infectious	Infectious	NNP
cord-017420-tjwxec77	215	60	Diseases	Diseases	NNPS
cord-017420-tjwxec77	215	61	Working	Working	NNP
cord-017420-tjwxec77	215	62	Party	Party	NNP
cord-017420-tjwxec77	215	63	(	(	-LRB-
cord-017420-tjwxec77	215	64	AGIHO	AGIHO	NNP
cord-017420-tjwxec77	215	65	)	)	-RRB-
cord-017420-tjwxec77	215	66	of	of	IN
cord-017420-tjwxec77	215	67	the	the	DT
cord-017420-tjwxec77	215	68	German	German	NNP
cord-017420-tjwxec77	215	69	Society	Society	NNP
cord-017420-tjwxec77	215	70	of	of	IN
cord-017420-tjwxec77	215	71	Hematology	Hematology	NNP
cord-017420-tjwxec77	215	72	and	and	CC
cord-017420-tjwxec77	215	73	Medical	Medical	NNP
cord-017420-tjwxec77	215	74	Oncology	Oncology	NNP
cord-017420-tjwxec77	216	1	(	(	-LRB-
cord-017420-tjwxec77	216	2	DGHO	DGHO	NNP
cord-017420-tjwxec77	216	3	)	)	-RRB-
cord-017420-tjwxec77	217	1	Febrile	febrile	JJ
cord-017420-tjwxec77	217	2	neutropenia	neutropenia	NN
cord-017420-tjwxec77	217	3	:	:	:
cord-017420-tjwxec77	218	1	significance	significance	NN
cord-017420-tjwxec77	218	2	of	of	IN
cord-017420-tjwxec77	218	3	elaborated	elaborate	VBN
cord-017420-tjwxec77	218	4	screening	screening	NN
cord-017420-tjwxec77	218	5	for	for	IN
cord-017420-tjwxec77	218	6	respiratory	respiratory	JJ
cord-017420-tjwxec77	218	7	viruses	virus	NNS
cord-017420-tjwxec77	218	8	,	,	,
cord-017420-tjwxec77	218	9	and	and	CC
cord-017420-tjwxec77	218	10	the	the	DT
cord-017420-tjwxec77	218	11	comparison	comparison	NN
cord-017420-tjwxec77	218	12	of	of	IN
cord-017420-tjwxec77	218	13	different	different	JJ
cord-017420-tjwxec77	218	14	sampling	sampling	NN
cord-017420-tjwxec77	218	15	methods	method	NNS
cord-017420-tjwxec77	218	16	,	,	,
cord-017420-tjwxec77	218	17	in	in	IN
cord-017420-tjwxec77	218	18	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	218	19	patients	patient	NNS
cord-017420-tjwxec77	218	20	with	with	IN
cord-017420-tjwxec77	218	21	hematological	hematological	JJ
cord-017420-tjwxec77	218	22	malignancies	malignancy	NNS
cord-017420-tjwxec77	219	1	The	the	DT
cord-017420-tjwxec77	219	2	Multinational	Multinational	NNP
cord-017420-tjwxec77	219	3	Association	Association	NNP
cord-017420-tjwxec77	219	4	for	for	IN
cord-017420-tjwxec77	219	5	Supportive	Supportive	NNP
cord-017420-tjwxec77	219	6	Care	Care	NNP
cord-017420-tjwxec77	219	7	in	in	IN
cord-017420-tjwxec77	219	8	Cancer	Cancer	NNP
cord-017420-tjwxec77	219	9	risk	risk	NN
cord-017420-tjwxec77	219	10	index	index	NN
cord-017420-tjwxec77	219	11	:	:	:
cord-017420-tjwxec77	219	12	a	a	DT
cord-017420-tjwxec77	219	13	multinational	multinational	JJ
cord-017420-tjwxec77	219	14	scoring	scoring	NN
cord-017420-tjwxec77	219	15	system	system	NN
cord-017420-tjwxec77	219	16	for	for	IN
cord-017420-tjwxec77	219	17	identifying	identify	VBG
cord-017420-tjwxec77	219	18	low	low	JJ
cord-017420-tjwxec77	219	19	-	-	HYPH
cord-017420-tjwxec77	219	20	risk	risk	NN
cord-017420-tjwxec77	219	21	febrile	febrile	JJ
cord-017420-tjwxec77	219	22	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	219	23	cancer	cancer	NN
cord-017420-tjwxec77	219	24	patients	patient	NNS
cord-017420-tjwxec77	219	25	Neutrophil	Neutrophil	NNP
cord-017420-tjwxec77	219	26	recruitment	recruitment	NN
cord-017420-tjwxec77	219	27	and	and	CC
cord-017420-tjwxec77	219	28	function	function	NN
cord-017420-tjwxec77	219	29	in	in	IN
cord-017420-tjwxec77	219	30	health	health	NN
cord-017420-tjwxec77	219	31	and	and	CC
cord-017420-tjwxec77	219	32	inflammation	inflammation	NN
cord-017420-tjwxec77	219	33	Mortality	mortality	NN
cord-017420-tjwxec77	219	34	,	,	,
cord-017420-tjwxec77	219	35	morbidity	morbidity	NN
cord-017420-tjwxec77	219	36	,	,	,
cord-017420-tjwxec77	219	37	and	and	CC
cord-017420-tjwxec77	219	38	cost	cost	NN
cord-017420-tjwxec77	219	39	associated	associate	VBN
cord-017420-tjwxec77	219	40	with	with	IN
cord-017420-tjwxec77	219	41	febrile	febrile	JJ
cord-017420-tjwxec77	219	42	neutropenia	neutropenia	NN
cord-017420-tjwxec77	219	43	in	in	IN
cord-017420-tjwxec77	219	44	adult	adult	NN
cord-017420-tjwxec77	219	45	cancer	cancer	NN
cord-017420-tjwxec77	219	46	patients	patient	NNS
cord-017420-tjwxec77	219	47	Milwaukee	Milwaukee	NNP
cord-017420-tjwxec77	219	48	Initiative	Initiative	NNP
cord-017420-tjwxec77	219	49	in	in	IN
cord-017420-tjwxec77	219	50	Critical	Critical	NNP
cord-017420-tjwxec77	219	51	Care	Care	NNP
cord-017420-tjwxec77	219	52	Outcomes	Outcomes	NNPS
cord-017420-tjwxec77	219	53	Research	Research	NNP
cord-017420-tjwxec77	219	54	Group	Group	NNP
cord-017420-tjwxec77	219	55	of	of	IN
cord-017420-tjwxec77	219	56	,	,	,
cord-017420-tjwxec77	219	57	I.	I.	NNP
cord-017420-tjwxec77	219	58	Severe	severe	JJ
cord-017420-tjwxec77	219	59	sepsis	sepsis	NN
cord-017420-tjwxec77	219	60	in	in	IN
cord-017420-tjwxec77	219	61	hematopoietic	hematopoietic	JJ
cord-017420-tjwxec77	219	62	stem	stem	NN
cord-017420-tjwxec77	219	63	cell	cell	NN
cord-017420-tjwxec77	219	64	transplant	transplant	NN
cord-017420-tjwxec77	219	65	recipients	recipient	NNS
cord-017420-tjwxec77	219	66	*	*	NFP
cord-017420-tjwxec77	219	67	Survival	survival	NN
cord-017420-tjwxec77	219	68	in	in	IN
cord-017420-tjwxec77	219	69	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	219	70	patients	patient	NNS
cord-017420-tjwxec77	219	71	with	with	IN
cord-017420-tjwxec77	219	72	severe	severe	JJ
cord-017420-tjwxec77	219	73	sepsis	sepsis	NN
cord-017420-tjwxec77	219	74	or	or	CC
cord-017420-tjwxec77	219	75	septic	septic	JJ
cord-017420-tjwxec77	219	76	shock	shock	NN
cord-017420-tjwxec77	220	1	The	the	DT
cord-017420-tjwxec77	220	2	role	role	NN
cord-017420-tjwxec77	220	3	of	of	IN
cord-017420-tjwxec77	220	4	neutrophils	neutrophil	NNS
cord-017420-tjwxec77	220	5	in	in	IN
cord-017420-tjwxec77	220	6	immune	immune	JJ
cord-017420-tjwxec77	220	7	dysfunction	dysfunction	NN
cord-017420-tjwxec77	220	8	during	during	IN
cord-017420-tjwxec77	220	9	severe	severe	JJ
cord-017420-tjwxec77	220	10	inflammation	inflammation	NN
cord-017420-tjwxec77	220	11	Groupe	Groupe	NNP
cord-017420-tjwxec77	220	12	de	de	FW
cord-017420-tjwxec77	220	13	Recherche	recherche	FW
cord-017420-tjwxec77	220	14	en	en	NNP
cord-017420-tjwxec77	220	15	Reanimation	Reanimation	NNP
cord-017420-tjwxec77	220	16	Respiratoire	Respiratoire	NNP
cord-017420-tjwxec77	220	17	du	du	NNP
cord-017420-tjwxec77	220	18	Patient	Patient	NNP
cord-017420-tjwxec77	220	19	,	,	,
cord-017420-tjwxec77	220	20	D.	D.	NNP
cord-017420-tjwxec77	220	21	O.-H.	O.-H.	NNP
cord-017420-tjwxec77	220	22	Effect	Effect	NNP
cord-017420-tjwxec77	220	23	of	of	IN
cord-017420-tjwxec77	220	24	noninvasive	noninvasive	JJ
cord-017420-tjwxec77	220	25	ventilation	ventilation	NN
cord-017420-tjwxec77	220	26	vs	vs	IN
cord-017420-tjwxec77	220	27	oxygen	oxygen	NN
cord-017420-tjwxec77	220	28	therapy	therapy	NN
cord-017420-tjwxec77	220	29	on	on	IN
cord-017420-tjwxec77	220	30	mortality	mortality	NN
cord-017420-tjwxec77	220	31	among	among	IN
cord-017420-tjwxec77	220	32	immunocompromised	immunocompromised	JJ
cord-017420-tjwxec77	220	33	patients	patient	NNS
cord-017420-tjwxec77	220	34	with	with	IN
cord-017420-tjwxec77	220	35	acute	acute	JJ
cord-017420-tjwxec77	220	36	respiratory	respiratory	JJ
cord-017420-tjwxec77	220	37	failure	failure	NN
cord-017420-tjwxec77	220	38	:	:	:
cord-017420-tjwxec77	220	39	a	a	DT
cord-017420-tjwxec77	220	40	randomized	randomized	JJ
cord-017420-tjwxec77	220	41	clinical	clinical	JJ
cord-017420-tjwxec77	220	42	trial	trial	NN
cord-017420-tjwxec77	220	43	Acute	acute	JJ
cord-017420-tjwxec77	220	44	respiratory	respiratory	JJ
cord-017420-tjwxec77	220	45	failure	failure	NN
cord-017420-tjwxec77	220	46	in	in	IN
cord-017420-tjwxec77	220	47	patients	patient	NNS
cord-017420-tjwxec77	220	48	with	with	IN
cord-017420-tjwxec77	220	49	hematological	hematological	JJ
cord-017420-tjwxec77	220	50	malignancies	malignancy	NNS
cord-017420-tjwxec77	220	51	:	:	:
cord-017420-tjwxec77	220	52	outcomes	outcome	NNS
cord-017420-tjwxec77	220	53	according	accord	VBG
cord-017420-tjwxec77	220	54	to	to	IN
cord-017420-tjwxec77	220	55	initial	initial	JJ
cord-017420-tjwxec77	220	56	ventilation	ventilation	NN
cord-017420-tjwxec77	220	57	strategy	strategy	NN
cord-017420-tjwxec77	220	58	.	.	.
cord-017420-tjwxec77	221	1	A	a	DT
cord-017420-tjwxec77	221	2	groupe	groupe	FW
cord-017420-tjwxec77	221	3	de	de	FW
cord-017420-tjwxec77	221	4	recherche	recherche	FW
cord-017420-tjwxec77	221	5	respiratoire	respiratoire	NNP
cord-017420-tjwxec77	221	6	en	en	IN
cord-017420-tjwxec77	221	7	reanimation	reanimation	NNP
cord-017420-tjwxec77	221	8	oncohematologique	oncohematologique	NNP
cord-017420-tjwxec77	222	1	(	(	-LRB-
cord-017420-tjwxec77	222	2	Grrr	grrr	UH
cord-017420-tjwxec77	222	3	-	-	HYPH
cord-017420-tjwxec77	222	4	OH	OH	NNP
cord-017420-tjwxec77	222	5	)	)	-RRB-
cord-017420-tjwxec77	222	6	study	study	VB
cord-017420-tjwxec77	222	7	The	the	DT
cord-017420-tjwxec77	222	8	significance	significance	NN
cord-017420-tjwxec77	222	9	and	and	CC
cord-017420-tjwxec77	222	10	regulatory	regulatory	JJ
cord-017420-tjwxec77	222	11	mechanisms	mechanism	NNS
cord-017420-tjwxec77	222	12	of	of	IN
cord-017420-tjwxec77	222	13	innate	innate	JJ
cord-017420-tjwxec77	222	14	immune	immune	JJ
cord-017420-tjwxec77	222	15	cells	cell	NNS
cord-017420-tjwxec77	222	16	in	in	IN
cord-017420-tjwxec77	222	17	the	the	DT
cord-017420-tjwxec77	222	18	development	development	NN
cord-017420-tjwxec77	222	19	of	of	IN
cord-017420-tjwxec77	222	20	sepsis	sepsis	NN
cord-017420-tjwxec77	222	21	Hematopoietic	Hematopoietic	NNP
cord-017420-tjwxec77	222	22	stem	stem	NN
cord-017420-tjwxec77	222	23	cell	cell	NN
cord-017420-tjwxec77	222	24	compartment	compartment	NN
cord-017420-tjwxec77	222	25	:	:	:
cord-017420-tjwxec77	222	26	acute	acute	JJ
cord-017420-tjwxec77	222	27	and	and	CC
cord-017420-tjwxec77	222	28	late	late	JJ
cord-017420-tjwxec77	222	29	effects	effect	NNS
cord-017420-tjwxec77	222	30	of	of	IN
cord-017420-tjwxec77	222	31	radiation	radiation	NN
cord-017420-tjwxec77	222	32	therapy	therapy	NN
cord-017420-tjwxec77	222	33	and	and	CC
cord-017420-tjwxec77	222	34	chemotherapy	chemotherapy	NN
cord-017420-tjwxec77	222	35	Neutrophils	Neutrophils	NNP
cord-017420-tjwxec77	222	36	in	in	IN
cord-017420-tjwxec77	222	37	critical	critical	JJ
cord-017420-tjwxec77	222	38	illness	illness	NN
cord-017420-tjwxec77	222	39	Platelets	platelet	NNS
cord-017420-tjwxec77	222	40	in	in	IN
cord-017420-tjwxec77	222	41	pulmonary	pulmonary	JJ
cord-017420-tjwxec77	222	42	immune	immune	JJ
cord-017420-tjwxec77	222	43	responses	response	NNS
cord-017420-tjwxec77	222	44	and	and	CC
cord-017420-tjwxec77	222	45	inflammatory	inflammatory	JJ
cord-017420-tjwxec77	222	46	lung	lung	NN
cord-017420-tjwxec77	222	47	diseases	disease	NNS
cord-017420-tjwxec77	223	1	Prognosis	prognosis	NN
cord-017420-tjwxec77	223	2	of	of	IN
cord-017420-tjwxec77	223	3	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	223	4	patients	patient	NNS
cord-017420-tjwxec77	223	5	admitted	admit	VBN
cord-017420-tjwxec77	223	6	to	to	IN
cord-017420-tjwxec77	223	7	the	the	DT
cord-017420-tjwxec77	223	8	intensive	intensive	JJ
cord-017420-tjwxec77	223	9	care	care	NN
cord-017420-tjwxec77	223	10	unit	unit	NN
cord-017420-tjwxec77	223	11	Deactivation	deactivation	NN
cord-017420-tjwxec77	223	12	of	of	IN
cord-017420-tjwxec77	223	13	alveolar	alveolar	JJ
cord-017420-tjwxec77	223	14	macrophages	macrophage	NNS
cord-017420-tjwxec77	223	15	in	in	IN
cord-017420-tjwxec77	223	16	septic	septic	JJ
cord-017420-tjwxec77	223	17	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	223	18	ARDS	ARDS	NNP
cord-017420-tjwxec77	223	19	Monocyte	Monocyte	NNP
cord-017420-tjwxec77	223	20	deactivation	deactivation	NN
cord-017420-tjwxec77	223	21	in	in	IN
cord-017420-tjwxec77	223	22	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	223	23	acute	acute	JJ
cord-017420-tjwxec77	223	24	respiratory	respiratory	JJ
cord-017420-tjwxec77	223	25	distress	distress	NN
cord-017420-tjwxec77	223	26	syndrome	syndrome	NN
cord-017420-tjwxec77	223	27	patients	patient	NNS
cord-017420-tjwxec77	223	28	treated	treat	VBN
cord-017420-tjwxec77	223	29	with	with	IN
cord-017420-tjwxec77	223	30	granulocyte	granulocyte	NN
cord-017420-tjwxec77	223	31	colony	colony	NN
cord-017420-tjwxec77	223	32	-	-	HYPH
cord-017420-tjwxec77	223	33	stimulating	stimulate	VBG
cord-017420-tjwxec77	223	34	factor	factor	NN
cord-017420-tjwxec77	224	1	Recent	recent	JJ
cord-017420-tjwxec77	224	2	changes	change	NNS
cord-017420-tjwxec77	224	3	in	in	IN
cord-017420-tjwxec77	224	4	bacteremia	bacteremia	NN
cord-017420-tjwxec77	224	5	in	in	IN
cord-017420-tjwxec77	224	6	patients	patient	NNS
cord-017420-tjwxec77	224	7	with	with	IN
cord-017420-tjwxec77	224	8	cancer	cancer	NN
cord-017420-tjwxec77	224	9	:	:	:
cord-017420-tjwxec77	224	10	a	a	DT
cord-017420-tjwxec77	224	11	systematic	systematic	JJ
cord-017420-tjwxec77	224	12	review	review	NN
cord-017420-tjwxec77	224	13	of	of	IN
cord-017420-tjwxec77	224	14	epidemiology	epidemiology	NN
cord-017420-tjwxec77	224	15	and	and	CC
cord-017420-tjwxec77	224	16	antibiotic	antibiotic	JJ
cord-017420-tjwxec77	224	17	resistance	resistance	NN
cord-017420-tjwxec77	224	18	Neutropenic	Neutropenic	NNP
cord-017420-tjwxec77	224	19	enterocolitis	enterocolitis	NN
cord-017420-tjwxec77	224	20	,	,	,
cord-017420-tjwxec77	224	21	a	a	DT
cord-017420-tjwxec77	224	22	growing	grow	VBG
cord-017420-tjwxec77	224	23	concern	concern	NN
cord-017420-tjwxec77	224	24	in	in	IN
cord-017420-tjwxec77	224	25	the	the	DT
cord-017420-tjwxec77	224	26	era	era	NN
cord-017420-tjwxec77	224	27	of	of	IN
cord-017420-tjwxec77	224	28	widespread	widespread	JJ
cord-017420-tjwxec77	224	29	use	use	NN
cord-017420-tjwxec77	224	30	of	of	IN
cord-017420-tjwxec77	224	31	aggressive	aggressive	JJ
cord-017420-tjwxec77	224	32	chemotherapy	chemotherapy	NN
cord-017420-tjwxec77	224	33	Noninvasive	noninvasive	JJ
cord-017420-tjwxec77	224	34	ventilation	ventilation	NN
cord-017420-tjwxec77	224	35	during	during	IN
cord-017420-tjwxec77	224	36	acute	acute	JJ
cord-017420-tjwxec77	224	37	respiratory	respiratory	JJ
cord-017420-tjwxec77	224	38	distress	distress	NN
cord-017420-tjwxec77	224	39	syndrome	syndrome	NN
cord-017420-tjwxec77	224	40	in	in	IN
cord-017420-tjwxec77	224	41	patients	patient	NNS
cord-017420-tjwxec77	224	42	with	with	IN
cord-017420-tjwxec77	224	43	cancer	cancer	NN
cord-017420-tjwxec77	224	44	:	:	:
cord-017420-tjwxec77	224	45	trends	trend	NNS
cord-017420-tjwxec77	224	46	in	in	IN
cord-017420-tjwxec77	224	47	use	use	NN
cord-017420-tjwxec77	224	48	and	and	CC
cord-017420-tjwxec77	224	49	outcome	outcome	NN
cord-017420-tjwxec77	224	50	Impact	impact	NN
cord-017420-tjwxec77	224	51	of	of	IN
cord-017420-tjwxec77	224	52	vancomycin	vancomycin	NN
cord-017420-tjwxec77	224	53	-	-	HYPH
cord-017420-tjwxec77	224	54	resistant	resistant	JJ
cord-017420-tjwxec77	224	55	enterococcal	enterococcal	JJ
cord-017420-tjwxec77	224	56	bacteremia	bacteremia	NN
cord-017420-tjwxec77	224	57	on	on	IN
cord-017420-tjwxec77	224	58	outcome	outcome	NN
cord-017420-tjwxec77	224	59	during	during	IN
cord-017420-tjwxec77	224	60	acute	acute	JJ
cord-017420-tjwxec77	224	61	myeloid	myeloid	JJ
cord-017420-tjwxec77	224	62	leukemia	leukemia	NN
cord-017420-tjwxec77	224	63	induction	induction	NN
cord-017420-tjwxec77	224	64	therapy	therapy	NN
cord-017420-tjwxec77	224	65	Neuromuscular	neuromuscular	JJ
cord-017420-tjwxec77	224	66	blockers	blocker	NNS
cord-017420-tjwxec77	224	67	in	in	IN
cord-017420-tjwxec77	224	68	early	early	JJ
cord-017420-tjwxec77	224	69	acute	acute	JJ
cord-017420-tjwxec77	224	70	respiratory	respiratory	JJ
cord-017420-tjwxec77	224	71	distress	distress	NN
cord-017420-tjwxec77	224	72	syndrome	syndrome	NN
cord-017420-tjwxec77	224	73	Beta	beta	NN
cord-017420-tjwxec77	224	74	-	-	HYPH
cord-017420-tjwxec77	224	75	lactam	lactam	NN
cord-017420-tjwxec77	224	76	versus	versus	IN
cord-017420-tjwxec77	224	77	beta	beta	NN
cord-017420-tjwxec77	224	78	-	-	HYPH
cord-017420-tjwxec77	224	79	lactam	lactam	NN
cord-017420-tjwxec77	224	80	-	-	HYPH
cord-017420-tjwxec77	224	81	aminoglycoside	aminoglycoside	NN
cord-017420-tjwxec77	224	82	combination	combination	NN
cord-017420-tjwxec77	224	83	therapy	therapy	NN
cord-017420-tjwxec77	224	84	in	in	IN
cord-017420-tjwxec77	224	85	cancer	cancer	NN
cord-017420-tjwxec77	224	86	patients	patient	NNS
cord-017420-tjwxec77	224	87	with	with	IN
cord-017420-tjwxec77	224	88	neutropenia	neutropenia	NN
cord-017420-tjwxec77	224	89	Beta	Beta	NNP
cord-017420-tjwxec77	224	90	lactam	lactam	NN
cord-017420-tjwxec77	224	91	monotherapy	monotherapy	NN
cord-017420-tjwxec77	224	92	versus	versus	IN
cord-017420-tjwxec77	224	93	beta	beta	JJ
cord-017420-tjwxec77	224	94	lactam	lactam	NN
cord-017420-tjwxec77	224	95	-	-	HYPH
cord-017420-tjwxec77	224	96	aminoglycoside	aminoglycoside	NN
cord-017420-tjwxec77	224	97	combination	combination	NN
cord-017420-tjwxec77	224	98	therapy	therapy	NN
cord-017420-tjwxec77	224	99	for	for	IN
cord-017420-tjwxec77	224	100	fever	fever	NN
cord-017420-tjwxec77	224	101	with	with	IN
cord-017420-tjwxec77	224	102	neutropenia	neutropenia	NN
cord-017420-tjwxec77	224	103	:	:	:
cord-017420-tjwxec77	225	1	systematic	systematic	JJ
cord-017420-tjwxec77	225	2	review	review	NN
cord-017420-tjwxec77	225	3	and	and	CC
cord-017420-tjwxec77	225	4	meta	meta	NNP
cord-017420-tjwxec77	225	5	-	-	HYPH
cord-017420-tjwxec77	225	6	analysis	analysis	NN
cord-017420-tjwxec77	225	7	Management	Management	NNP
cord-017420-tjwxec77	225	8	of	of	IN
cord-017420-tjwxec77	225	9	sepsis	sepsis	NN
cord-017420-tjwxec77	225	10	in	in	IN
cord-017420-tjwxec77	225	11	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	225	12	patients	patient	NNS
cord-017420-tjwxec77	225	13	:	:	:
cord-017420-tjwxec77	226	1	2014	2014	CD
cord-017420-tjwxec77	226	2	updated	update	VBN
cord-017420-tjwxec77	226	3	guidelines	guideline	NNS
cord-017420-tjwxec77	226	4	from	from	IN
cord-017420-tjwxec77	226	5	the	the	DT
cord-017420-tjwxec77	226	6	Infectious	Infectious	NNP
cord-017420-tjwxec77	226	7	Diseases	Diseases	NNPS
cord-017420-tjwxec77	226	8	Working	Working	NNP
cord-017420-tjwxec77	226	9	Party	Party	NNP
cord-017420-tjwxec77	226	10	of	of	IN
cord-017420-tjwxec77	226	11	the	the	DT
cord-017420-tjwxec77	226	12	German	German	NNP
cord-017420-tjwxec77	226	13	Society	Society	NNP
cord-017420-tjwxec77	226	14	of	of	IN
cord-017420-tjwxec77	226	15	Extended	Extended	NNP
cord-017420-tjwxec77	226	16	versus	versus	IN
cord-017420-tjwxec77	226	17	bolus	bolus	NN
cord-017420-tjwxec77	226	18	infusion	infusion	NN
cord-017420-tjwxec77	226	19	of	of	IN
cord-017420-tjwxec77	226	20	broad	broad	JJ
cord-017420-tjwxec77	226	21	spectrum	spectrum	NN
cord-017420-tjwxec77	226	22	beta	beta	NN
cord-017420-tjwxec77	226	23	-	-	HYPH
cord-017420-tjwxec77	226	24	lactams	lactam	NNS
cord-017420-tjwxec77	226	25	for	for	IN
cord-017420-tjwxec77	226	26	febrile	febrile	JJ
cord-017420-tjwxec77	226	27	neutropenia	neutropenia	NN
cord-017420-tjwxec77	226	28	:	:	:
cord-017420-tjwxec77	227	1	an	an	DT
cord-017420-tjwxec77	227	2	unblinded	unblinded	JJ
cord-017420-tjwxec77	227	3	randomized	randomized	JJ
cord-017420-tjwxec77	227	4	trial	trial	NN
cord-017420-tjwxec77	227	5	Changes	change	NNS
cord-017420-tjwxec77	227	6	in	in	IN
cord-017420-tjwxec77	227	7	the	the	DT
cord-017420-tjwxec77	227	8	etiology	etiology	NN
cord-017420-tjwxec77	227	9	of	of	IN
cord-017420-tjwxec77	227	10	bacteremia	bacteremia	NN
cord-017420-tjwxec77	227	11	in	in	IN
cord-017420-tjwxec77	227	12	febrile	febrile	JJ
cord-017420-tjwxec77	227	13	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	227	14	patients	patient	NNS
cord-017420-tjwxec77	227	15	and	and	CC
cord-017420-tjwxec77	227	16	the	the	DT
cord-017420-tjwxec77	227	17	susceptibilities	susceptibility	NNS
cord-017420-tjwxec77	227	18	of	of	IN
cord-017420-tjwxec77	227	19	the	the	DT
cord-017420-tjwxec77	227	20	currently	currently	RB
cord-017420-tjwxec77	227	21	isolated	isolate	VBN
cord-017420-tjwxec77	227	22	pathogens	pathogen	NNS
cord-017420-tjwxec77	227	23	Neutropenic	Neutropenic	NNP
cord-017420-tjwxec77	227	24	sepsis	sepsis	NN
cord-017420-tjwxec77	227	25	is	be	VBZ
cord-017420-tjwxec77	227	26	associated	associate	VBN
cord-017420-tjwxec77	227	27	with	with	IN
cord-017420-tjwxec77	227	28	distinct	distinct	JJ
cord-017420-tjwxec77	227	29	clinical	clinical	JJ
cord-017420-tjwxec77	227	30	and	and	CC
cord-017420-tjwxec77	227	31	biological	biological	JJ
cord-017420-tjwxec77	227	32	characteristics	characteristic	NNS
cord-017420-tjwxec77	227	33	:	:	:
cord-017420-tjwxec77	227	34	a	a	DT
cord-017420-tjwxec77	227	35	cohort	cohort	NN
cord-017420-tjwxec77	227	36	study	study	NN
cord-017420-tjwxec77	227	37	of	of	IN
cord-017420-tjwxec77	227	38	severe	severe	JJ
cord-017420-tjwxec77	227	39	sepsis	sepsis	NN
cord-017420-tjwxec77	227	40	Surviving	survive	VBG
cord-017420-tjwxec77	227	41	sepsis	sepsis	NN
cord-017420-tjwxec77	227	42	campaign	campaign	NN
cord-017420-tjwxec77	227	43	:	:	:
cord-017420-tjwxec77	227	44	international	international	NNP
cord-017420-tjwxec77	227	45	guidelines	guideline	NNS
cord-017420-tjwxec77	227	46	for	for	IN
cord-017420-tjwxec77	227	47	management	management	NN
cord-017420-tjwxec77	227	48	of	of	IN
cord-017420-tjwxec77	227	49	sepsis	sepsis	NN
cord-017420-tjwxec77	227	50	and	and	CC
cord-017420-tjwxec77	228	1	septic	septic	NNP
cord-017420-tjwxec77	228	2	shock	shock	NN
cord-017420-tjwxec77	228	3	Cohort	Cohort	NNP
cord-017420-tjwxec77	228	4	study	study	NN
cord-017420-tjwxec77	228	5	of	of	IN
cord-017420-tjwxec77	228	6	the	the	DT
cord-017420-tjwxec77	228	7	impact	impact	NN
cord-017420-tjwxec77	228	8	of	of	IN
cord-017420-tjwxec77	228	9	time	time	NN
cord-017420-tjwxec77	228	10	to	to	IN
cord-017420-tjwxec77	228	11	antibiotic	antibiotic	JJ
cord-017420-tjwxec77	228	12	administration	administration	NN
cord-017420-tjwxec77	228	13	on	on	IN
cord-017420-tjwxec77	228	14	mortality	mortality	NN
cord-017420-tjwxec77	228	15	in	in	IN
cord-017420-tjwxec77	228	16	patients	patient	NNS
cord-017420-tjwxec77	228	17	with	with	IN
cord-017420-tjwxec77	228	18	febrile	febrile	JJ
cord-017420-tjwxec77	228	19	neutropenia	neutropenia	NN
cord-017420-tjwxec77	228	20	Neutropenic	Neutropenic	NNP
cord-017420-tjwxec77	228	21	enterocolitis	enterocolitis	NN
cord-017420-tjwxec77	228	22	:	:	:
cord-017420-tjwxec77	228	23	new	new	JJ
cord-017420-tjwxec77	228	24	insights	insight	NNS
cord-017420-tjwxec77	228	25	into	into	IN
cord-017420-tjwxec77	228	26	a	a	DT
cord-017420-tjwxec77	228	27	deadly	deadly	JJ
cord-017420-tjwxec77	228	28	entity	entity	NN
cord-017420-tjwxec77	229	1	The	the	DT
cord-017420-tjwxec77	229	2	prognostic	prognostic	JJ
cord-017420-tjwxec77	229	3	impact	impact	NN
cord-017420-tjwxec77	229	4	of	of	IN
cord-017420-tjwxec77	229	5	abdominal	abdominal	JJ
cord-017420-tjwxec77	229	6	surgery	surgery	NN
cord-017420-tjwxec77	229	7	in	in	IN
cord-017420-tjwxec77	229	8	cancer	cancer	NN
cord-017420-tjwxec77	229	9	patients	patient	NNS
cord-017420-tjwxec77	229	10	with	with	IN
cord-017420-tjwxec77	229	11	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	229	12	enterocolitis	enterocolitis	NN
cord-017420-tjwxec77	229	13	:	:	:
cord-017420-tjwxec77	229	14	a	a	DT
cord-017420-tjwxec77	229	15	systematic	systematic	JJ
cord-017420-tjwxec77	229	16	review	review	NN
cord-017420-tjwxec77	229	17	and	and	CC
cord-017420-tjwxec77	229	18	meta	meta	NNP
cord-017420-tjwxec77	229	19	-	-	HYPH
cord-017420-tjwxec77	229	20	analysis	analysis	NNP
cord-017420-tjwxec77	229	21	,	,	,
cord-017420-tjwxec77	229	22	on	on	IN
cord-017420-tjwxec77	229	23	behalf	behalf	NN
cord-017420-tjwxec77	229	24	the	the	DT
cord-017420-tjwxec77	229	25	Groupe	Groupe	NNP
cord-017420-tjwxec77	229	26	de	de	FW
cord-017420-tjwxec77	229	27	Recherche	recherche	FW
cord-017420-tjwxec77	229	28	en	en	NNP
cord-017420-tjwxec77	229	29	Reanimation	Reanimation	NNP
cord-017420-tjwxec77	229	30	Respiratoire	Respiratoire	NNP
cord-017420-tjwxec77	229	31	du	du	NNP
cord-017420-tjwxec77	229	32	patient	patient	NN
cord-017420-tjwxec77	229	33	d'Onco	d'onco	NN
cord-017420-tjwxec77	229	34	-	-	HYPH
cord-017420-tjwxec77	229	35	Hematologie	Hematologie	NNP
cord-017420-tjwxec77	229	36	(	(	-LRB-
cord-017420-tjwxec77	230	1	GRRR	GRRR	NNP
cord-017420-tjwxec77	230	2	-	-	HYPH
cord-017420-tjwxec77	230	3	OH	OH	NNP
cord-017420-tjwxec77	230	4	)	)	-RRB-
cord-017420-tjwxec77	230	5	Efficacy	efficacy	NN
cord-017420-tjwxec77	230	6	and	and	CC
cord-017420-tjwxec77	230	7	safety	safety	NN
cord-017420-tjwxec77	230	8	of	of	IN
cord-017420-tjwxec77	230	9	withholding	withhold	VBG
cord-017420-tjwxec77	230	10	antimicrobial	antimicrobial	JJ
cord-017420-tjwxec77	230	11	treatment	treatment	NN
cord-017420-tjwxec77	230	12	in	in	IN
cord-017420-tjwxec77	230	13	children	child	NNS
cord-017420-tjwxec77	230	14	with	with	IN
cord-017420-tjwxec77	230	15	cancer	cancer	NN
cord-017420-tjwxec77	230	16	,	,	,
cord-017420-tjwxec77	230	17	fever	fever	NN
cord-017420-tjwxec77	230	18	and	and	CC
cord-017420-tjwxec77	230	19	neutropenia	neutropenia	NN
cord-017420-tjwxec77	230	20	,	,	,
cord-017420-tjwxec77	230	21	with	with	IN
cord-017420-tjwxec77	230	22	a	a	DT
cord-017420-tjwxec77	230	23	demonstrated	demonstrate	VBN
cord-017420-tjwxec77	230	24	viral	viral	JJ
cord-017420-tjwxec77	230	25	respiratory	respiratory	JJ
cord-017420-tjwxec77	230	26	infection	infection	NN
cord-017420-tjwxec77	230	27	:	:	:
cord-017420-tjwxec77	230	28	a	a	DT
cord-017420-tjwxec77	230	29	randomized	randomized	JJ
cord-017420-tjwxec77	230	30	clinical	clinical	JJ
cord-017420-tjwxec77	230	31	trial	trial	NN
cord-017420-tjwxec77	231	1	The	the	DT
cord-017420-tjwxec77	231	2	global	global	JJ
cord-017420-tjwxec77	231	3	challenge	challenge	NN
cord-017420-tjwxec77	231	4	of	of	IN
cord-017420-tjwxec77	231	5	carbapenem	carbapenem	JJ
cord-017420-tjwxec77	231	6	-	-	HYPH
cord-017420-tjwxec77	231	7	resistant	resistant	JJ
cord-017420-tjwxec77	231	8	Enterobacteriaceae	Enterobacteriaceae	NNP
cord-017420-tjwxec77	231	9	in	in	IN
cord-017420-tjwxec77	231	10	transplant	transplant	NN
cord-017420-tjwxec77	231	11	recipients	recipient	NNS
cord-017420-tjwxec77	231	12	and	and	CC
cord-017420-tjwxec77	231	13	patients	patient	NNS
cord-017420-tjwxec77	231	14	with	with	IN
cord-017420-tjwxec77	231	15	hematologic	hematologic	JJ
cord-017420-tjwxec77	231	16	malignancies	malignancy	NNS
cord-017420-tjwxec77	231	17	Absolute	absolute	JJ
cord-017420-tjwxec77	231	18	lymphocyte	lymphocyte	NN
cord-017420-tjwxec77	231	19	count	count	NN
cord-017420-tjwxec77	231	20	on	on	IN
cord-017420-tjwxec77	231	21	day	day	NN
cord-017420-tjwxec77	231	22	30	30	CD
cord-017420-tjwxec77	231	23	is	be	VBZ
cord-017420-tjwxec77	231	24	a	a	DT
cord-017420-tjwxec77	231	25	surrogate	surrogate	NN
cord-017420-tjwxec77	231	26	for	for	IN
cord-017420-tjwxec77	231	27	robust	robust	JJ
cord-017420-tjwxec77	231	28	hematopoietic	hematopoietic	JJ
cord-017420-tjwxec77	231	29	recovery	recovery	NN
cord-017420-tjwxec77	231	30	and	and	CC
cord-017420-tjwxec77	231	31	strongly	strongly	RB
cord-017420-tjwxec77	231	32	predicts	predict	VBZ
cord-017420-tjwxec77	231	33	outcome	outcome	NN
cord-017420-tjwxec77	231	34	after	after	IN
cord-017420-tjwxec77	231	35	T	T	NNP
cord-017420-tjwxec77	231	36	cell	cell	NN
cord-017420-tjwxec77	231	37	-	-	HYPH
cord-017420-tjwxec77	231	38	depleted	deplete	VBN
cord-017420-tjwxec77	231	39	allogeneic	allogeneic	NN
cord-017420-tjwxec77	231	40	stem	stem	NN
cord-017420-tjwxec77	231	41	cell	cell	NN
cord-017420-tjwxec77	231	42	transplantation	transplantation	NN
cord-017420-tjwxec77	231	43	Investigators	investigator	NNS
cord-017420-tjwxec77	231	44	,	,	,
cord-017420-tjwxec77	231	45	S.-E.	S.-E.	NNP
cord-017420-tjwxec77	231	46	Balanced	balanced	JJ
cord-017420-tjwxec77	231	47	crystalloids	crystalloid	NNS
cord-017420-tjwxec77	231	48	versus	versus	IN
cord-017420-tjwxec77	231	49	saline	saline	NN
cord-017420-tjwxec77	231	50	in	in	IN
cord-017420-tjwxec77	231	51	noncritically	noncritically	RB
cord-017420-tjwxec77	231	52	ill	ill	JJ
cord-017420-tjwxec77	231	53	adults	adult	NNS
cord-017420-tjwxec77	232	1	Investigators	investigator	NNS
cord-017420-tjwxec77	232	2	,	,	,
cord-017420-tjwxec77	232	3	S	S	NNP
cord-017420-tjwxec77	232	4	,	,	,
cord-017420-tjwxec77	232	5	The	the	DT
cord-017420-tjwxec77	232	6	Pragmatic	Pragmatic	NNP
cord-017420-tjwxec77	232	7	Critical	Critical	NNP
cord-017420-tjwxec77	232	8	Care	Care	NNP
cord-017420-tjwxec77	232	9	Research	Research	NNP
cord-017420-tjwxec77	232	10	,	,	,
cord-017420-tjwxec77	232	11	G.	G.	NNP
cord-017420-tjwxec77	232	12	Balanced	Balanced	NNP
cord-017420-tjwxec77	232	13	crystalloids	crystalloid	NNS
cord-017420-tjwxec77	232	14	versus	versus	IN
cord-017420-tjwxec77	232	15	saline	saline	NN
cord-017420-tjwxec77	232	16	in	in	IN
cord-017420-tjwxec77	232	17	critically	critically	RB
cord-017420-tjwxec77	232	18	ill	ill	JJ
cord-017420-tjwxec77	232	19	adults	adult	NNS
cord-017420-tjwxec77	233	1	The	the	DT
cord-017420-tjwxec77	233	2	third	third	JJ
cord-017420-tjwxec77	233	3	international	international	JJ
cord-017420-tjwxec77	233	4	consensus	consensus	NN
cord-017420-tjwxec77	233	5	definitions	definition	NNS
cord-017420-tjwxec77	233	6	for	for	IN
cord-017420-tjwxec77	233	7	sepsis	sepsis	NN
cord-017420-tjwxec77	233	8	and	and	CC
cord-017420-tjwxec77	234	1	septic	septic	JJ
cord-017420-tjwxec77	234	2	shock	shock	NN
cord-017420-tjwxec77	234	3	(	(	-LRB-
cord-017420-tjwxec77	234	4	sepsis-3	sepsis-3	NNP
cord-017420-tjwxec77	234	5	)	)	-RRB-
cord-017420-tjwxec77	234	6	Comparison	comparison	NN
cord-017420-tjwxec77	234	7	of	of	IN
cord-017420-tjwxec77	234	8	immune	immune	JJ
cord-017420-tjwxec77	234	9	reconstitution	reconstitution	NN
cord-017420-tjwxec77	234	10	after	after	IN
cord-017420-tjwxec77	234	11	unrelated	unrelated	JJ
cord-017420-tjwxec77	234	12	and	and	CC
cord-017420-tjwxec77	234	13	related	related	JJ
cord-017420-tjwxec77	234	14	T	t	NN
cord-017420-tjwxec77	234	15	-	-	HYPH
cord-017420-tjwxec77	234	16	cell	cell	NN
cord-017420-tjwxec77	234	17	-	-	HYPH
cord-017420-tjwxec77	234	18	depleted	deplete	VBN
cord-017420-tjwxec77	234	19	bone	bone	NN
cord-017420-tjwxec77	234	20	marrow	marrow	NN
cord-017420-tjwxec77	234	21	transplantation	transplantation	NN
cord-017420-tjwxec77	234	22	:	:	:
cord-017420-tjwxec77	234	23	effect	effect	NN
cord-017420-tjwxec77	234	24	of	of	IN
cord-017420-tjwxec77	234	25	patient	patient	JJ
cord-017420-tjwxec77	234	26	age	age	NN
cord-017420-tjwxec77	234	27	and	and	CC
cord-017420-tjwxec77	234	28	donor	donor	NN
cord-017420-tjwxec77	234	29	leukocyte	leukocyte	NN
cord-017420-tjwxec77	234	30	infusions	infusion	NNS
cord-017420-tjwxec77	234	31	American	American	NNP
cord-017420-tjwxec77	234	32	Society	Society	NNP
cord-017420-tjwxec77	234	33	of	of	IN
cord-017420-tjwxec77	234	34	Clinical	Clinical	NNP
cord-017420-tjwxec77	234	35	,	,	,
cord-017420-tjwxec77	234	36	O.	O.	NNP
cord-017420-tjwxec77	234	37	Recommendations	Recommendations	NNPS
cord-017420-tjwxec77	234	38	for	for	IN
cord-017420-tjwxec77	234	39	the	the	DT
cord-017420-tjwxec77	234	40	use	use	NN
cord-017420-tjwxec77	234	41	of	of	IN
cord-017420-tjwxec77	234	42	WBC	WBC	NNP
cord-017420-tjwxec77	234	43	growth	growth	NN
cord-017420-tjwxec77	234	44	factors	factor	NNS
cord-017420-tjwxec77	234	45	Impact	Impact	NNP
cord-017420-tjwxec77	234	46	of	of	IN
cord-017420-tjwxec77	234	47	neutropenia	neutropenia	NN
cord-017420-tjwxec77	234	48	on	on	IN
cord-017420-tjwxec77	234	49	the	the	DT
cord-017420-tjwxec77	234	50	outcomes	outcome	NNS
cord-017420-tjwxec77	234	51	of	of	IN
cord-017420-tjwxec77	234	52	critically	critically	RB
cord-017420-tjwxec77	234	53	ill	ill	JJ
cord-017420-tjwxec77	234	54	patients	patient	NNS
cord-017420-tjwxec77	234	55	with	with	IN
cord-017420-tjwxec77	234	56	cancer	cancer	NN
cord-017420-tjwxec77	234	57	:	:	:
cord-017420-tjwxec77	234	58	a	a	DT
cord-017420-tjwxec77	234	59	matched	match	VBN
cord-017420-tjwxec77	234	60	case	case	NN
cord-017420-tjwxec77	234	61	-	-	HYPH
cord-017420-tjwxec77	234	62	control	control	NN
cord-017420-tjwxec77	234	63	study	study	NN
cord-017420-tjwxec77	234	64	Small	small	JJ
cord-017420-tjwxec77	234	65	but	but	CC
cord-017420-tjwxec77	234	66	mighty	mighty	JJ
cord-017420-tjwxec77	234	67	:	:	:
cord-017420-tjwxec77	234	68	platelets	platelet	NNS
cord-017420-tjwxec77	234	69	as	as	IN
cord-017420-tjwxec77	234	70	central	central	JJ
cord-017420-tjwxec77	234	71	effectors	effector	NNS
cord-017420-tjwxec77	234	72	of	of	IN
cord-017420-tjwxec77	234	73	host	host	NN
cord-017420-tjwxec77	234	74	defense	defense	NN
cord-017420-tjwxec77	234	75	Cost	cost	NN
cord-017420-tjwxec77	234	76	of	of	IN
cord-017420-tjwxec77	234	77	cancer	cancer	NN
cord-017420-tjwxec77	234	78	-	-	HYPH
cord-017420-tjwxec77	234	79	related	relate	VBN
cord-017420-tjwxec77	234	80	neutropenia	neutropenia	NN
cord-017420-tjwxec77	234	81	or	or	CC
cord-017420-tjwxec77	234	82	fever	fever	NN
cord-017420-tjwxec77	234	83	hospitalizations	hospitalization	NNS
cord-017420-tjwxec77	234	84	,	,	,
cord-017420-tjwxec77	234	85	United	United	NNP
cord-017420-tjwxec77	234	86	States	States	NNP
cord-017420-tjwxec77	234	87	Neutrophil	Neutrophil	NNP
cord-017420-tjwxec77	234	88	-	-	HYPH
cord-017420-tjwxec77	234	89	mediated	mediate	VBN
cord-017420-tjwxec77	234	90	suppression	suppression	NN
cord-017420-tjwxec77	234	91	of	of	IN
cord-017420-tjwxec77	234	92	influenza	influenza	NN
cord-017420-tjwxec77	234	93	Hemabis	Hemabis	NNP
cord-017420-tjwxec77	234	94	Registry	Registry	NNP
cord-017420-tjwxec77	234	95	-	-	HYPH
cord-017420-tjwxec77	234	96	Seifem	Seifem	NNP
cord-017420-tjwxec77	234	97	Group	Group	NNP
cord-017420-tjwxec77	234	98	,	,	,
cord-017420-tjwxec77	234	99	I.	I.	NNP
cord-017420-tjwxec77	234	100	Current	current	JJ
cord-017420-tjwxec77	234	101	epidemiology	epidemiology	NN
cord-017420-tjwxec77	234	102	and	and	CC
cord-017420-tjwxec77	234	103	antimicrobial	antimicrobial	JJ
cord-017420-tjwxec77	234	104	resistance	resistance	NN
cord-017420-tjwxec77	234	105	data	datum	NNS
cord-017420-tjwxec77	234	106	for	for	IN
cord-017420-tjwxec77	234	107	bacterial	bacterial	JJ
cord-017420-tjwxec77	234	108	bloodstream	bloodstream	NN
cord-017420-tjwxec77	234	109	infections	infection	NNS
cord-017420-tjwxec77	234	110	in	in	IN
cord-017420-tjwxec77	234	111	patients	patient	NNS
cord-017420-tjwxec77	234	112	with	with	IN
cord-017420-tjwxec77	234	113	hematologic	hematologic	JJ
cord-017420-tjwxec77	234	114	malignancies	malignancy	NNS
cord-017420-tjwxec77	234	115	:	:	:
cord-017420-tjwxec77	234	116	an	an	DT
cord-017420-tjwxec77	234	117	Italian	italian	JJ
cord-017420-tjwxec77	234	118	multicentre	multicentre	NNP
cord-017420-tjwxec77	234	119	prospective	prospective	JJ
cord-017420-tjwxec77	234	120	survey	survey	NN
cord-017420-tjwxec77	234	121	Mucosal	Mucosal	NNP
cord-017420-tjwxec77	234	122	barrier	barrier	NN
cord-017420-tjwxec77	234	123	injury	injury	NN
cord-017420-tjwxec77	234	124	,	,	,
cord-017420-tjwxec77	234	125	fever	fever	NN
cord-017420-tjwxec77	234	126	and	and	CC
cord-017420-tjwxec77	234	127	infection	infection	NN
cord-017420-tjwxec77	234	128	in	in	IN
cord-017420-tjwxec77	234	129	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	234	130	patients	patient	NNS
cord-017420-tjwxec77	234	131	with	with	IN
cord-017420-tjwxec77	234	132	cancer	cancer	NN
cord-017420-tjwxec77	234	133	:	:	:
cord-017420-tjwxec77	234	134	introducing	introduce	VBG
cord-017420-tjwxec77	234	135	the	the	DT
cord-017420-tjwxec77	234	136	paradigm	paradigm	NN
cord-017420-tjwxec77	235	1	febrile	febrile	JJ
cord-017420-tjwxec77	235	2	mucositis	mucositis	NNP
cord-017420-tjwxec77	236	1	The	the	DT
cord-017420-tjwxec77	236	2	SOFA	sofa	NN
cord-017420-tjwxec77	236	3	(	(	-LRB-
cord-017420-tjwxec77	236	4	Sepsis	sepsis	NN
cord-017420-tjwxec77	236	5	-	-	HYPH
cord-017420-tjwxec77	236	6	related	relate	VBN
cord-017420-tjwxec77	236	7	Organ	Organ	NNP
cord-017420-tjwxec77	236	8	Failure	Failure	NNP
cord-017420-tjwxec77	236	9	Assessment	Assessment	NNP
cord-017420-tjwxec77	236	10	)	)	-RRB-
cord-017420-tjwxec77	236	11	score	score	NN
cord-017420-tjwxec77	236	12	to	to	TO
cord-017420-tjwxec77	236	13	describe	describe	VB
cord-017420-tjwxec77	236	14	organ	organ	NN
cord-017420-tjwxec77	236	15	dysfunction	dysfunction	NN
cord-017420-tjwxec77	236	16	/	/	SYM
cord-017420-tjwxec77	236	17	failure	failure	NN
cord-017420-tjwxec77	236	18	.	.	.
cord-017420-tjwxec77	237	1	On	on	IN
cord-017420-tjwxec77	237	2	behalf	behalf	NN
cord-017420-tjwxec77	237	3	of	of	IN
cord-017420-tjwxec77	237	4	the	the	DT
cord-017420-tjwxec77	237	5	Working	Working	NNP
cord-017420-tjwxec77	237	6	Group	Group	NNP
cord-017420-tjwxec77	237	7	on	on	IN
cord-017420-tjwxec77	237	8	Sepsis	sepsis	NN
cord-017420-tjwxec77	237	9	-	-	HYPH
cord-017420-tjwxec77	237	10	Related	relate	VBN
cord-017420-tjwxec77	237	11	Problems	problem	NNS
cord-017420-tjwxec77	237	12	of	of	IN
cord-017420-tjwxec77	237	13	the	the	DT
cord-017420-tjwxec77	237	14	European	European	NNP
cord-017420-tjwxec77	237	15	Society	Society	NNP
cord-017420-tjwxec77	237	16	of	of	IN
cord-017420-tjwxec77	237	17	Intensive	Intensive	NNP
cord-017420-tjwxec77	237	18	Care	Care	NNP
cord-017420-tjwxec77	237	19	Medicine	Medicine	NNP
cord-017420-tjwxec77	238	1	The	the	DT
cord-017420-tjwxec77	238	2	use	use	NN
cord-017420-tjwxec77	238	3	of	of	IN
cord-017420-tjwxec77	238	4	FDG	FDG	NNP
cord-017420-tjwxec77	238	5	-	-	HYPH
cord-017420-tjwxec77	238	6	PET	PET	NNP
cord-017420-tjwxec77	238	7	/	/	SYM
cord-017420-tjwxec77	238	8	CT	CT	NNP
cord-017420-tjwxec77	238	9	in	in	IN
cord-017420-tjwxec77	238	10	patients	patient	NNS
cord-017420-tjwxec77	238	11	with	with	IN
cord-017420-tjwxec77	238	12	febrile	febrile	JJ
cord-017420-tjwxec77	238	13	neutropenia	neutropenia	NN
cord-017420-tjwxec77	238	14	Liposomal	Liposomal	NNP
cord-017420-tjwxec77	238	15	amphotericin	amphotericin	NNS
cord-017420-tjwxec77	238	16	B	b	NN
cord-017420-tjwxec77	238	17	for	for	IN
cord-017420-tjwxec77	238	18	empirical	empirical	JJ
cord-017420-tjwxec77	238	19	therapy	therapy	NN
cord-017420-tjwxec77	238	20	in	in	IN
cord-017420-tjwxec77	238	21	patients	patient	NNS
cord-017420-tjwxec77	238	22	with	with	IN
cord-017420-tjwxec77	238	23	persistent	persistent	JJ
cord-017420-tjwxec77	238	24	fever	fever	NN
cord-017420-tjwxec77	238	25	and	and	CC
cord-017420-tjwxec77	238	26	neutropenia	neutropenia	NN
cord-017420-tjwxec77	238	27	.	.	.
cord-017420-tjwxec77	239	1	National	National	NNP
cord-017420-tjwxec77	239	2	Institute	Institute	NNP
cord-017420-tjwxec77	239	3	of	of	IN
cord-017420-tjwxec77	239	4	Allergy	Allergy	NNP
cord-017420-tjwxec77	239	5	and	and	CC
cord-017420-tjwxec77	239	6	Infectious	Infectious	NNP
cord-017420-tjwxec77	239	7	Diseases	Diseases	NNPS
cord-017420-tjwxec77	240	1	Mycoses	Mycoses	NNP
cord-017420-tjwxec77	240	2	Study	Study	NNP
cord-017420-tjwxec77	240	3	Group	Group	NNP
cord-017420-tjwxec77	240	4	Caspofungin	Caspofungin	NNP
cord-017420-tjwxec77	240	5	versus	versus	IN
cord-017420-tjwxec77	240	6	liposomal	liposomal	JJ
cord-017420-tjwxec77	240	7	amphotericin	amphotericin	NNS
cord-017420-tjwxec77	240	8	B	B	NNP
cord-017420-tjwxec77	240	9	for	for	IN
cord-017420-tjwxec77	240	10	empirical	empirical	JJ
cord-017420-tjwxec77	240	11	antifungal	antifungal	JJ
cord-017420-tjwxec77	240	12	therapy	therapy	NN
cord-017420-tjwxec77	240	13	in	in	IN
cord-017420-tjwxec77	240	14	patients	patient	NNS
cord-017420-tjwxec77	240	15	with	with	IN
cord-017420-tjwxec77	240	16	persistent	persistent	JJ
cord-017420-tjwxec77	240	17	fever	fever	NN
cord-017420-tjwxec77	240	18	and	and	CC
cord-017420-tjwxec77	240	19	neutropenia	neutropenia	NN
cord-017420-tjwxec77	240	20	Prediction	Prediction	NNP
cord-017420-tjwxec77	240	21	of	of	IN
cord-017420-tjwxec77	240	22	bloodstream	bloodstream	NN
cord-017420-tjwxec77	240	23	infection	infection	NN
cord-017420-tjwxec77	240	24	due	due	JJ
cord-017420-tjwxec77	240	25	to	to	IN
cord-017420-tjwxec77	240	26	vancomycin	vancomycin	NN
cord-017420-tjwxec77	240	27	-	-	HYPH
cord-017420-tjwxec77	240	28	resistant	resistant	JJ
cord-017420-tjwxec77	240	29	enterococcus	enterococcus	NN
cord-017420-tjwxec77	240	30	in	in	IN
cord-017420-tjwxec77	240	31	patients	patient	NNS
cord-017420-tjwxec77	240	32	undergoing	undergo	VBG
cord-017420-tjwxec77	240	33	leukemia	leukemia	NN
cord-017420-tjwxec77	240	34	induction	induction	NN
cord-017420-tjwxec77	240	35	or	or	CC
cord-017420-tjwxec77	240	36	hematopoietic	hematopoietic	JJ
cord-017420-tjwxec77	240	37	stem	stem	NN
cord-017420-tjwxec77	240	38	-	-	HYPH
cord-017420-tjwxec77	240	39	cell	cell	NN
cord-017420-tjwxec77	240	40	transplantation	transplantation	NN
cord-017420-tjwxec77	240	41	Association	Association	NNP
cord-017420-tjwxec77	240	42	between	between	IN
cord-017420-tjwxec77	240	43	early	early	JJ
cord-017420-tjwxec77	240	44	peak	peak	NN
cord-017420-tjwxec77	240	45	temperature	temperature	NN
cord-017420-tjwxec77	240	46	and	and	CC
cord-017420-tjwxec77	240	47	mortality	mortality	NN
cord-017420-tjwxec77	240	48	in	in	IN
cord-017420-tjwxec77	240	49	neutropenic	neutropenic	JJ
cord-017420-tjwxec77	240	50	sepsis	sepsis	NN
cord-017420-tjwxec77	240	51	Colonization	colonization	NN
cord-017420-tjwxec77	240	52	,	,	,
cord-017420-tjwxec77	240	53	bloodstream	bloodstream	NN
cord-017420-tjwxec77	240	54	infection	infection	NN
cord-017420-tjwxec77	240	55	,	,	,
cord-017420-tjwxec77	240	56	and	and	CC
cord-017420-tjwxec77	240	57	mortality	mortality	NN
cord-017420-tjwxec77	240	58	caused	cause	VBN
cord-017420-tjwxec77	240	59	by	by	IN
cord-017420-tjwxec77	240	60	vancomycin	vancomycin	NN
cord-017420-tjwxec77	240	61	-	-	HYPH
cord-017420-tjwxec77	240	62	resistant	resistant	JJ
cord-017420-tjwxec77	240	63	enterococcus	enterococcus	NN
cord-017420-tjwxec77	240	64	early	early	RB
cord-017420-tjwxec77	240	65	after	after	IN
cord-017420-tjwxec77	240	66	allogeneic	allogeneic	JJ
cord-017420-tjwxec77	240	67	hematopoietic	hematopoietic	JJ
cord-017420-tjwxec77	240	68	stem	stem	NN
cord-017420-tjwxec77	240	69	cell	cell	NN
cord-017420-tjwxec77	240	70	transplant	transplant	NN
cord-017420-tjwxec77	240	71	Platelets	platelet	NNS
cord-017420-tjwxec77	240	72	in	in	IN
cord-017420-tjwxec77	240	73	the	the	DT
cord-017420-tjwxec77	240	74	pathogenesis	pathogenesis	NN
cord-017420-tjwxec77	240	75	of	of	IN
cord-017420-tjwxec77	240	76	acute	acute	JJ
cord-017420-tjwxec77	240	77	respiratory	respiratory	JJ
cord-017420-tjwxec77	240	78	distress	distress	NN
cord-017420-tjwxec77	240	79	syndrome	syndrome	NN
cord-017420-tjwxec77	241	1	The	the	DT
cord-017420-tjwxec77	241	2	utility	utility	NN
cord-017420-tjwxec77	241	3	of	of	IN
cord-017420-tjwxec77	241	4	routine	routine	JJ
cord-017420-tjwxec77	241	5	chest	chest	NN
cord-017420-tjwxec77	241	6	radiography	radiography	NN
cord-017420-tjwxec77	241	7	in	in	IN
cord-017420-tjwxec77	241	8	the	the	DT
cord-017420-tjwxec77	241	9	initial	initial	JJ
cord-017420-tjwxec77	241	10	evaluation	evaluation	NN
cord-017420-tjwxec77	241	11	of	of	IN
cord-017420-tjwxec77	241	12	adult	adult	NN
cord-017420-tjwxec77	241	13	patients	patient	NNS
cord-017420-tjwxec77	241	14	with	with	IN
cord-017420-tjwxec77	241	15	febrile	febrile	JJ
cord-017420-tjwxec77	241	16	neutropenia	neutropenia	NN
cord-017420-tjwxec77	241	17	patients	patient	NNS
cord-017420-tjwxec77	241	18	undergoing	undergo	VBG
cord-017420-tjwxec77	241	19	HSCT	HSCT	NNP