id sid tid token lemma pos cord-016990-ot1wi3xi 1 1 key key NN cord-016990-ot1wi3xi 1 2 : : : cord-016990-ot1wi3xi 2 1 cord-016990-ot1wi3xi cord-016990-ot1wi3xi NNP cord-016990-ot1wi3xi 2 2 authors author NNS cord-016990-ot1wi3xi 2 3 : : : cord-016990-ot1wi3xi 2 4 Zaki Zaki NNP cord-016990-ot1wi3xi 2 5 , , , cord-016990-ot1wi3xi 2 6 Sherif Sherif NNP cord-016990-ot1wi3xi 2 7 R. R. NNP cord-016990-ot1wi3xi 2 8 ; ; : cord-016990-ot1wi3xi 2 9 Paddock Paddock NNP cord-016990-ot1wi3xi 2 10 , , , cord-016990-ot1wi3xi 2 11 Christopher Christopher NNP cord-016990-ot1wi3xi 2 12 D. D. NNP cord-016990-ot1wi3xi 2 13 title title NN cord-016990-ot1wi3xi 2 14 : : : cord-016990-ot1wi3xi 2 15 Viral Viral NNP cord-016990-ot1wi3xi 2 16 Infections Infections NNPS cord-016990-ot1wi3xi 2 17 of of IN cord-016990-ot1wi3xi 2 18 the the DT cord-016990-ot1wi3xi 2 19 Lung Lung NNP cord-016990-ot1wi3xi 2 20 date date NN cord-016990-ot1wi3xi 2 21 : : : cord-016990-ot1wi3xi 2 22 2008 2008 CD cord-016990-ot1wi3xi 2 23 journal journal NN cord-016990-ot1wi3xi 2 24 : : : cord-016990-ot1wi3xi 2 25 Dail Dail NNP cord-016990-ot1wi3xi 2 26 and and CC cord-016990-ot1wi3xi 2 27 Hammar’s Hammar’s NNP cord-016990-ot1wi3xi 2 28 Pulmonary Pulmonary NNP cord-016990-ot1wi3xi 2 29 Pathology Pathology NNP cord-016990-ot1wi3xi 3 1 DOI DOI NNP cord-016990-ot1wi3xi 3 2 : : : cord-016990-ot1wi3xi 4 1 10.1007/978 10.1007/978 LS cord-016990-ot1wi3xi 4 2 - - HYPH cord-016990-ot1wi3xi 4 3 0 0 CD cord-016990-ot1wi3xi 4 4 - - HYPH cord-016990-ot1wi3xi 4 5 387 387 CD cord-016990-ot1wi3xi 4 6 - - HYPH cord-016990-ot1wi3xi 4 7 68792 68792 CD cord-016990-ot1wi3xi 4 8 - - HYPH cord-016990-ot1wi3xi 4 9 6_11 6_11 CD cord-016990-ot1wi3xi 4 10 sha sha NNP cord-016990-ot1wi3xi 4 11 : : : cord-016990-ot1wi3xi 5 1 abd32872c84c1a8c21091d295c5d0f0dd937f380 abd32872c84c1a8c21091d295c5d0f0dd937f380 LS cord-016990-ot1wi3xi 5 2 doc_id doc_id CD cord-016990-ot1wi3xi 5 3 : : : cord-016990-ot1wi3xi 5 4 16990 16990 CD cord-016990-ot1wi3xi 5 5 cord_uid cord_uid NNS cord-016990-ot1wi3xi 5 6 : : : cord-016990-ot1wi3xi 6 1 ot1wi3xi ot1wi3xi NNP cord-016990-ot1wi3xi 7 1 The the DT cord-016990-ot1wi3xi 7 2 lungs lung NNS cord-016990-ot1wi3xi 7 3 are be VBP cord-016990-ot1wi3xi 7 4 among among IN cord-016990-ot1wi3xi 7 5 the the DT cord-016990-ot1wi3xi 7 6 most most RBS cord-016990-ot1wi3xi 7 7 vulnerable vulnerable JJ cord-016990-ot1wi3xi 7 8 to to IN cord-016990-ot1wi3xi 7 9 microbial microbial JJ cord-016990-ot1wi3xi 7 10 assault assault NN cord-016990-ot1wi3xi 7 11 of of IN cord-016990-ot1wi3xi 7 12 all all DT cord-016990-ot1wi3xi 7 13 organs organ NNS cord-016990-ot1wi3xi 7 14 in in IN cord-016990-ot1wi3xi 7 15 the the DT cord-016990-ot1wi3xi 7 16 body body NN cord-016990-ot1wi3xi 7 17 . . . cord-016990-ot1wi3xi 8 1 From from IN cord-016990-ot1wi3xi 8 2 a a DT cord-016990-ot1wi3xi 8 3 contemporary contemporary JJ cord-016990-ot1wi3xi 8 4 vantage vantage NN cord-016990-ot1wi3xi 8 5 , , , cord-016990-ot1wi3xi 8 6 lower low JJR cord-016990-ot1wi3xi 8 7 respiratory respiratory JJ cord-016990-ot1wi3xi 8 8 tract tract NN cord-016990-ot1wi3xi 8 9 infections infection NNS cord-016990-ot1wi3xi 8 10 are be VBP cord-016990-ot1wi3xi 8 11 the the DT cord-016990-ot1wi3xi 8 12 greatest great JJS cord-016990-ot1wi3xi 8 13 cause cause NN cord-016990-ot1wi3xi 8 14 of of IN cord-016990-ot1wi3xi 8 15 infection infection NN cord-016990-ot1wi3xi 8 16 - - HYPH cord-016990-ot1wi3xi 8 17 related relate VBN cord-016990-ot1wi3xi 8 18 mortality mortality NN cord-016990-ot1wi3xi 8 19 in in IN cord-016990-ot1wi3xi 8 20 the the DT cord-016990-ot1wi3xi 8 21 United United NNP cord-016990-ot1wi3xi 8 22 States States NNP cord-016990-ot1wi3xi 8 23 , , , cord-016990-ot1wi3xi 8 24 and and CC cord-016990-ot1wi3xi 8 25 rank rank VBP cord-016990-ot1wi3xi 8 26 seventh seventh JJ cord-016990-ot1wi3xi 8 27 among among IN cord-016990-ot1wi3xi 8 28 all all DT cord-016990-ot1wi3xi 8 29 causes cause NNS cord-016990-ot1wi3xi 8 30 of of IN cord-016990-ot1wi3xi 8 31 deaths death NNS cord-016990-ot1wi3xi 8 32 in in IN cord-016990-ot1wi3xi 8 33 the the DT cord-016990-ot1wi3xi 8 34 United United NNP cord-016990-ot1wi3xi 8 35 States.2,3 States.2,3 NNP cord-016990-ot1wi3xi 8 36 From from IN cord-016990-ot1wi3xi 8 37 a a DT cord-016990-ot1wi3xi 8 38 global global JJ cord-016990-ot1wi3xi 8 39 and and CC cord-016990-ot1wi3xi 8 40 historic historic JJ cord-016990-ot1wi3xi 8 41 perspective perspective NN cord-016990-ot1wi3xi 8 42 , , , cord-016990-ot1wi3xi 8 43 the the DT cord-016990-ot1wi3xi 8 44 scope scope NN cord-016990-ot1wi3xi 8 45 and and CC cord-016990-ot1wi3xi 8 46 scale scale NN cord-016990-ot1wi3xi 8 47 of of IN cord-016990-ot1wi3xi 8 48 lower low JJR cord-016990-ot1wi3xi 8 49 respiratory respiratory JJ cord-016990-ot1wi3xi 8 50 tract tract NN cord-016990-ot1wi3xi 8 51 infection infection NN cord-016990-ot1wi3xi 8 52 is be VBZ cord-016990-ot1wi3xi 8 53 greater great JJR cord-016990-ot1wi3xi 8 54 than than IN cord-016990-ot1wi3xi 8 55 any any DT cord-016990-ot1wi3xi 8 56 other other JJ cord-016990-ot1wi3xi 8 57 infectious infectious JJ cord-016990-ot1wi3xi 8 58 syndrome syndrome NN cord-016990-ot1wi3xi 8 59 , , , cord-016990-ot1wi3xi 8 60 and and CC cord-016990-ot1wi3xi 8 61 viral viral JJ cord-016990-ot1wi3xi 8 62 pneumonias pneumonia NNS cord-016990-ot1wi3xi 8 63 have have VBP cord-016990-ot1wi3xi 8 64 proven prove VBN cord-016990-ot1wi3xi 8 65 to to TO cord-016990-ot1wi3xi 8 66 be be VB cord-016990-ot1wi3xi 8 67 some some DT cord-016990-ot1wi3xi 8 68 of of IN cord-016990-ot1wi3xi 8 69 the the DT cord-016990-ot1wi3xi 8 70 most most RBS cord-016990-ot1wi3xi 8 71 lethal lethal JJ cord-016990-ot1wi3xi 8 72 and and CC cord-016990-ot1wi3xi 8 73 dramatic dramatic JJ cord-016990-ot1wi3xi 8 74 of of IN cord-016990-ot1wi3xi 8 75 human human JJ cord-016990-ot1wi3xi 8 76 diseases disease NNS cord-016990-ot1wi3xi 8 77 . . . cord-016990-ot1wi3xi 9 1 The the DT cord-016990-ot1wi3xi 9 2 1918–1919 1918–1919 CD cord-016990-ot1wi3xi 9 3 influenza influenza NN cord-016990-ot1wi3xi 9 4 pandemic pandemic NN cord-016990-ot1wi3xi 9 5 , , , cord-016990-ot1wi3xi 9 6 perhaps perhaps RB cord-016990-ot1wi3xi 9 7 the the DT cord-016990-ot1wi3xi 9 8 most most RBS cord-016990-ot1wi3xi 9 9 devastating devastating JJ cord-016990-ot1wi3xi 9 10 infectious infectious JJ cord-016990-ot1wi3xi 9 11 disease disease NN cord-016990-ot1wi3xi 9 12 pandemic pandemic NN cord-016990-ot1wi3xi 9 13 in in IN cord-016990-ot1wi3xi 9 14 recorded record VBN cord-016990-ot1wi3xi 9 15 history history NN cord-016990-ot1wi3xi 9 16 , , , cord-016990-ot1wi3xi 9 17 resulted result VBD cord-016990-ot1wi3xi 9 18 in in IN cord-016990-ot1wi3xi 9 19 an an DT cord-016990-ot1wi3xi 9 20 estimated estimate VBN cord-016990-ot1wi3xi 9 21 40 40 CD cord-016990-ot1wi3xi 9 22 million million CD cord-016990-ot1wi3xi 9 23 deaths death NNS cord-016990-ot1wi3xi 9 24 worldwide worldwide RB cord-016990-ot1wi3xi 9 25 , , , cord-016990-ot1wi3xi 9 26 including include VBG cord-016990-ot1wi3xi 9 27 700,000 700,000 CD cord-016990-ot1wi3xi 9 28 deaths death NNS cord-016990-ot1wi3xi 9 29 in in IN cord-016990-ot1wi3xi 9 30 the the DT cord-016990-ot1wi3xi 9 31 U.S.4 u.s.4 CD cord-016990-ot1wi3xi 9 32 The the DT cord-016990-ot1wi3xi 9 33 global global JJ cord-016990-ot1wi3xi 9 34 outbreak outbreak NN cord-016990-ot1wi3xi 9 35 of of IN cord-016990-ot1wi3xi 9 36 severe severe JJ cord-016990-ot1wi3xi 9 37 acute acute JJ cord-016990-ot1wi3xi 9 38 respiratory respiratory JJ cord-016990-ot1wi3xi 9 39 syndrome syndrome NN cord-016990-ot1wi3xi 9 40 ( ( -LRB- cord-016990-ot1wi3xi 9 41 SARS SARS NNP cord-016990-ot1wi3xi 9 42 ) ) -RRB- cord-016990-ot1wi3xi 9 43 during during IN cord-016990-ot1wi3xi 9 44 2003 2003 CD cord-016990-ot1wi3xi 9 45 , , , cord-016990-ot1wi3xi 9 46 although although IN cord-016990-ot1wi3xi 9 47 considerably considerably RB cord-016990-ot1wi3xi 9 48 smaller small JJR cord-016990-ot1wi3xi 9 49 in in IN cord-016990-ot1wi3xi 9 50 scale scale NN cord-016990-ot1wi3xi 9 51 , , , cord-016990-ot1wi3xi 9 52 resulted result VBD cord-016990-ot1wi3xi 9 53 in in IN cord-016990-ot1wi3xi 9 54 8098 8098 CD cord-016990-ot1wi3xi 9 55 cases case NNS cord-016990-ot1wi3xi 9 56 and and CC cord-016990-ot1wi3xi 9 57 774 774 CD cord-016990-ot1wi3xi 9 58 deaths5 deaths5 NN cord-016990-ot1wi3xi 9 59 and and CC cord-016990-ot1wi3xi 9 60 is be VBZ cord-016990-ot1wi3xi 9 61 a a DT cord-016990-ot1wi3xi 9 62 dramatic dramatic JJ cord-016990-ot1wi3xi 9 63 contemporary contemporary JJ cord-016990-ot1wi3xi 9 64 example example NN cord-016990-ot1wi3xi 9 65 of of IN cord-016990-ot1wi3xi 9 66 the the DT cord-016990-ot1wi3xi 9 67 ability ability NN cord-016990-ot1wi3xi 9 68 of of IN cord-016990-ot1wi3xi 9 69 viral viral JJ cord-016990-ot1wi3xi 9 70 pneumonias pneumonia NNS cord-016990-ot1wi3xi 9 71 to to TO cord-016990-ot1wi3xi 9 72 rapidly rapidly RB cord-016990-ot1wi3xi 9 73 disseminate disseminate VB cord-016990-ot1wi3xi 9 74 and and CC cord-016990-ot1wi3xi 9 75 cause cause VB cord-016990-ot1wi3xi 9 76 severe severe JJ cord-016990-ot1wi3xi 9 77 disease disease NN cord-016990-ot1wi3xi 9 78 in in IN cord-016990-ot1wi3xi 9 79 human human JJ cord-016990-ot1wi3xi 9 80 populations population NNS cord-016990-ot1wi3xi 9 81 . . . cord-016990-ot1wi3xi 10 1 The the DT cord-016990-ot1wi3xi 10 2 lungs lung NNS cord-016990-ot1wi3xi 10 3 are be VBP cord-016990-ot1wi3xi 10 4 among among IN cord-016990-ot1wi3xi 10 5 the the DT cord-016990-ot1wi3xi 10 6 most most RBS cord-016990-ot1wi3xi 10 7 vulnerable vulnerable JJ cord-016990-ot1wi3xi 10 8 to to IN cord-016990-ot1wi3xi 10 9 microbial microbial JJ cord-016990-ot1wi3xi 10 10 assault assault NN cord-016990-ot1wi3xi 10 11 of of IN cord-016990-ot1wi3xi 10 12 all all DT cord-016990-ot1wi3xi 10 13 organs organ NNS cord-016990-ot1wi3xi 10 14 in in IN cord-016990-ot1wi3xi 10 15 the the DT cord-016990-ot1wi3xi 10 16 body body NN cord-016990-ot1wi3xi 10 17 . . . cord-016990-ot1wi3xi 11 1 From from IN cord-016990-ot1wi3xi 11 2 a a DT cord-016990-ot1wi3xi 11 3 contemporary contemporary JJ cord-016990-ot1wi3xi 11 4 vantage vantage NN cord-016990-ot1wi3xi 11 5 , , , cord-016990-ot1wi3xi 11 6 lower low JJR cord-016990-ot1wi3xi 11 7 respiratory respiratory JJ cord-016990-ot1wi3xi 11 8 tract tract NN cord-016990-ot1wi3xi 11 9 infections infection NNS cord-016990-ot1wi3xi 11 10 are be VBP cord-016990-ot1wi3xi 11 11 the the DT cord-016990-ot1wi3xi 11 12 greatest great JJS cord-016990-ot1wi3xi 11 13 cause cause NN cord-016990-ot1wi3xi 11 14 of of IN cord-016990-ot1wi3xi 11 15 infection infection NN cord-016990-ot1wi3xi 11 16 - - HYPH cord-016990-ot1wi3xi 11 17 related relate VBN cord-016990-ot1wi3xi 11 18 mortality mortality NN cord-016990-ot1wi3xi 11 19 in in IN cord-016990-ot1wi3xi 11 20 the the DT cord-016990-ot1wi3xi 11 21 United United NNP cord-016990-ot1wi3xi 11 22 States States NNP cord-016990-ot1wi3xi 11 23 , , , cord-016990-ot1wi3xi 11 24 and and CC cord-016990-ot1wi3xi 11 25 rank rank VBP cord-016990-ot1wi3xi 11 26 seventh seventh JJ cord-016990-ot1wi3xi 11 27 among among IN cord-016990-ot1wi3xi 11 28 all all DT cord-016990-ot1wi3xi 11 29 causes cause NNS cord-016990-ot1wi3xi 11 30 of of IN cord-016990-ot1wi3xi 11 31 deaths death NNS cord-016990-ot1wi3xi 11 32 in in IN cord-016990-ot1wi3xi 11 33 the the DT cord-016990-ot1wi3xi 11 34 United United NNP cord-016990-ot1wi3xi 11 35 States States NNP cord-016990-ot1wi3xi 11 36 . . . cord-016990-ot1wi3xi 12 1 2 2 LS cord-016990-ot1wi3xi 12 2 , , , cord-016990-ot1wi3xi 12 3 3 3 CD cord-016990-ot1wi3xi 12 4 From from IN cord-016990-ot1wi3xi 12 5 a a DT cord-016990-ot1wi3xi 12 6 global global JJ cord-016990-ot1wi3xi 12 7 and and CC cord-016990-ot1wi3xi 12 8 historic historic JJ cord-016990-ot1wi3xi 12 9 perspective perspective NN cord-016990-ot1wi3xi 12 10 , , , cord-016990-ot1wi3xi 12 11 the the DT cord-016990-ot1wi3xi 12 12 scope scope NN cord-016990-ot1wi3xi 12 13 and and CC cord-016990-ot1wi3xi 12 14 scale scale NN cord-016990-ot1wi3xi 12 15 of of IN cord-016990-ot1wi3xi 12 16 lower low JJR cord-016990-ot1wi3xi 12 17 respiratory respiratory JJ cord-016990-ot1wi3xi 12 18 tract tract NN cord-016990-ot1wi3xi 12 19 infection infection NN cord-016990-ot1wi3xi 12 20 is be VBZ cord-016990-ot1wi3xi 12 21 greater great JJR cord-016990-ot1wi3xi 12 22 than than IN cord-016990-ot1wi3xi 12 23 any any DT cord-016990-ot1wi3xi 12 24 other other JJ cord-016990-ot1wi3xi 12 25 infectious infectious JJ cord-016990-ot1wi3xi 12 26 syndrome syndrome NN cord-016990-ot1wi3xi 12 27 , , , cord-016990-ot1wi3xi 12 28 and and CC cord-016990-ot1wi3xi 12 29 viral viral JJ cord-016990-ot1wi3xi 12 30 pneumonias pneumonia NNS cord-016990-ot1wi3xi 12 31 have have VBP cord-016990-ot1wi3xi 12 32 proven prove VBN cord-016990-ot1wi3xi 12 33 to to TO cord-016990-ot1wi3xi 12 34 be be VB cord-016990-ot1wi3xi 12 35 some some DT cord-016990-ot1wi3xi 12 36 of of IN cord-016990-ot1wi3xi 12 37 the the DT cord-016990-ot1wi3xi 12 38 most most RBS cord-016990-ot1wi3xi 12 39 lethal lethal JJ cord-016990-ot1wi3xi 12 40 and and CC cord-016990-ot1wi3xi 12 41 dramatic dramatic JJ cord-016990-ot1wi3xi 12 42 of of IN cord-016990-ot1wi3xi 12 43 human human JJ cord-016990-ot1wi3xi 12 44 diseases disease NNS cord-016990-ot1wi3xi 12 45 . . . cord-016990-ot1wi3xi 13 1 The the DT cord-016990-ot1wi3xi 13 2 1918 1918 CD cord-016990-ot1wi3xi 13 3 - - SYM cord-016990-ot1wi3xi 13 4 1919 1919 CD cord-016990-ot1wi3xi 13 5 influenza influenza NN cord-016990-ot1wi3xi 13 6 pandemic pandemic NN cord-016990-ot1wi3xi 13 7 , , , cord-016990-ot1wi3xi 13 8 perhaps perhaps RB cord-016990-ot1wi3xi 13 9 the the DT cord-016990-ot1wi3xi 13 10 most most RBS cord-016990-ot1wi3xi 13 11 devastating devastating JJ cord-016990-ot1wi3xi 13 12 infectious infectious JJ cord-016990-ot1wi3xi 13 13 disease disease NN cord-016990-ot1wi3xi 13 14 pandemic pandemic NN cord-016990-ot1wi3xi 13 15 in in IN cord-016990-ot1wi3xi 13 16 recorded record VBN cord-016990-ot1wi3xi 13 17 history history NN cord-016990-ot1wi3xi 13 18 , , , cord-016990-ot1wi3xi 13 19 resulted result VBD cord-016990-ot1wi3xi 13 20 in in IN cord-016990-ot1wi3xi 13 21 an an DT cord-016990-ot1wi3xi 13 22 estimated estimate VBN cord-016990-ot1wi3xi 13 23 40 40 CD cord-016990-ot1wi3xi 13 24 million million CD cord-016990-ot1wi3xi 13 25 deaths death NNS cord-016990-ot1wi3xi 13 26 worldwide worldwide RB cord-016990-ot1wi3xi 13 27 , , , cord-016990-ot1wi3xi 13 28 including include VBG cord-016990-ot1wi3xi 13 29 700,000 700,000 CD cord-016990-ot1wi3xi 13 30 deaths death NNS cord-016990-ot1wi3xi 13 31 in in IN cord-016990-ot1wi3xi 13 32 the the DT cord-016990-ot1wi3xi 13 33 US US NNP cord-016990-ot1wi3xi 13 34 . . . cord-016990-ot1wi3xi 14 1 4 4 LS cord-016990-ot1wi3xi 15 1 The the DT cord-016990-ot1wi3xi 15 2 global global JJ cord-016990-ot1wi3xi 15 3 outbreak outbreak NN cord-016990-ot1wi3xi 15 4 of of IN cord-016990-ot1wi3xi 15 5 severe severe JJ cord-016990-ot1wi3xi 15 6 acute acute JJ cord-016990-ot1wi3xi 15 7 respiratory respiratory JJ cord-016990-ot1wi3xi 15 8 syndrome syndrome NN cord-016990-ot1wi3xi 15 9 ( ( -LRB- cord-016990-ot1wi3xi 15 10 SARS SARS NNP cord-016990-ot1wi3xi 15 11 ) ) -RRB- cord-016990-ot1wi3xi 15 12 during during IN cord-016990-ot1wi3xi 15 13 2003 2003 CD cord-016990-ot1wi3xi 15 14 , , , cord-016990-ot1wi3xi 15 15 although although IN cord-016990-ot1wi3xi 15 16 considerably considerably RB cord-016990-ot1wi3xi 15 17 smaller small JJR cord-016990-ot1wi3xi 15 18 in in IN cord-016990-ot1wi3xi 15 19 scale scale NN cord-016990-ot1wi3xi 15 20 , , , cord-016990-ot1wi3xi 15 21 resulted result VBD cord-016990-ot1wi3xi 15 22 in in IN cord-016990-ot1wi3xi 15 23 8098 8098 CD cord-016990-ot1wi3xi 15 24 cases case NNS cord-016990-ot1wi3xi 15 25 and and CC cord-016990-ot1wi3xi 15 26 774 774 CD cord-016990-ot1wi3xi 15 27 deaths death NNS cord-016990-ot1wi3xi 15 28 S S NNP cord-016990-ot1wi3xi 15 29 and and CC cord-016990-ot1wi3xi 15 30 is be VBZ cord-016990-ot1wi3xi 15 31 a a DT cord-016990-ot1wi3xi 15 32 dramatic dramatic JJ cord-016990-ot1wi3xi 15 33 contemporary contemporary JJ cord-016990-ot1wi3xi 15 34 example example NN cord-016990-ot1wi3xi 15 35 of of IN cord-016990-ot1wi3xi 15 36 the the DT cord-016990-ot1wi3xi 15 37 ability ability NN cord-016990-ot1wi3xi 15 38 of of IN cord-016990-ot1wi3xi 15 39 viral viral JJ cord-016990-ot1wi3xi 15 40 pneumonias pneumonia NNS cord-016990-ot1wi3xi 15 41 to to TO cord-016990-ot1wi3xi 15 42 rapidly rapidly RB cord-016990-ot1wi3xi 15 43 disseminate disseminate VB cord-016990-ot1wi3xi 15 44 and and CC cord-016990-ot1wi3xi 15 45 cause cause VB cord-016990-ot1wi3xi 15 46 severe severe JJ cord-016990-ot1wi3xi 15 47 disease disease NN cord-016990-ot1wi3xi 15 48 in in IN cord-016990-ot1wi3xi 15 49 human human JJ cord-016990-ot1wi3xi 15 50 populations population NNS cord-016990-ot1wi3xi 15 51 . . . cord-016990-ot1wi3xi 16 1 Although although IN cord-016990-ot1wi3xi 16 2 viruses virus NNS cord-016990-ot1wi3xi 16 3 are be VBP cord-016990-ot1wi3xi 16 4 commonly commonly RB cord-016990-ot1wi3xi 16 5 identified identify VBN cord-016990-ot1wi3xi 16 6 causes cause NNS cord-016990-ot1wi3xi 16 7 of of IN cord-016990-ot1wi3xi 16 8 pneumonia pneumonia NN cord-016990-ot1wi3xi 16 9 of of IN cord-016990-ot1wi3xi 16 10 infants infant NNS cord-016990-ot1wi3xi 16 11 and and CC cord-016990-ot1wi3xi 16 12 young young JJ cord-016990-ot1wi3xi 16 13 children child NNS cord-016990-ot1wi3xi 16 14 , , , cord-016990-ot1wi3xi 16 15 they -PRON- PRP cord-016990-ot1wi3xi 16 16 are be VBP cord-016990-ot1wi3xi 16 17 relatively relatively RB cord-016990-ot1wi3xi 16 18 infrequently infrequently RB cord-016990-ot1wi3xi 16 19 recognized recognize VBN cord-016990-ot1wi3xi 16 20 as as IN cord-016990-ot1wi3xi 16 21 agents agent NNS cord-016990-ot1wi3xi 16 22 of of IN cord-016990-ot1wi3xi 16 23 communityacquired communityacquired JJ cord-016990-ot1wi3xi 16 24 pneumonia pneumonia NN cord-016990-ot1wi3xi 16 25 in in IN cord-016990-ot1wi3xi 16 26 adults adult NNS cord-016990-ot1wi3xi 16 27 . . . cord-016990-ot1wi3xi 17 1 6 6 CD cord-016990-ot1wi3xi 18 1 In in IN cord-016990-ot1wi3xi 18 2 several several JJ cord-016990-ot1wi3xi 18 3 large large JJ cord-016990-ot1wi3xi 18 4 series series NN cord-016990-ot1wi3xi 18 5 that that WDT cord-016990-ot1wi3xi 18 6 investigated investigate VBD cord-016990-ot1wi3xi 18 7 a a DT cord-016990-ot1wi3xi 18 8 microbiologic microbiologic JJ cord-016990-ot1wi3xi 18 9 cause cause NN cord-016990-ot1wi3xi 18 10 of of IN cord-016990-ot1wi3xi 18 11 community community NN cord-016990-ot1wi3xi 18 12 - - HYPH cord-016990-ot1wi3xi 18 13 acquired acquire VBN cord-016990-ot1wi3xi 18 14 pneumonia pneumonia NN cord-016990-ot1wi3xi 18 15 , , , cord-016990-ot1wi3xi 18 16 viral viral JJ cord-016990-ot1wi3xi 18 17 etiologies etiology NNS cord-016990-ot1wi3xi 18 18 were be VBD cord-016990-ot1wi3xi 18 19 identified identify VBN cord-016990-ot1wi3xi 18 20 in in IN cord-016990-ot1wi3xi 18 21 only only RB cord-016990-ot1wi3xi 18 22 9 9 CD cord-016990-ot1wi3xi 18 23 % % NN cord-016990-ot1wi3xi 18 24 to to IN cord-016990-ot1wi3xi 18 25 18 18 CD cord-016990-ot1wi3xi 18 26 % % NN cord-016990-ot1wi3xi 18 27 of of IN cord-016990-ot1wi3xi 18 28 cases case NNS cord-016990-ot1wi3xi 18 29 ( ( -LRB- cord-016990-ot1wi3xi 18 30 Table table NN cord-016990-ot1wi3xi 18 31 11 11 CD cord-016990-ot1wi3xi 18 32 .1).7 .1).7 . cord-016990-ot1wi3xi 19 1 -12 -12 . cord-016990-ot1wi3xi 20 1 However however RB cord-016990-ot1wi3xi 20 2 , , , cord-016990-ot1wi3xi 20 3 it -PRON- PRP cord-016990-ot1wi3xi 20 4 is be VBZ cord-016990-ot1wi3xi 20 5 likely likely JJ cord-016990-ot1wi3xi 20 6 that that IN cord-016990-ot1wi3xi 20 7 viral viral JJ cord-016990-ot1wi3xi 20 8 pneumonias pneumonia NNS cord-016990-ot1wi3xi 20 9 are be VBP cord-016990-ot1wi3xi 20 10 underrecognized underrecognize VBN cord-016990-ot1wi3xi 20 11 and and CC cord-016990-ot1wi3xi 20 12 underdiagnosed underdiagnosed JJ cord-016990-ot1wi3xi 20 13 for for IN cord-016990-ot1wi3xi 20 14 various various JJ cord-016990-ot1wi3xi 20 15 reasons reason NNS cord-016990-ot1wi3xi 20 16 . . . cord-016990-ot1wi3xi 21 1 Although although IN cord-016990-ot1wi3xi 21 2 some some DT cord-016990-ot1wi3xi 21 3 agents agent NNS cord-016990-ot1wi3xi 21 4 may may MD cord-016990-ot1wi3xi 21 5 cause cause VB cord-016990-ot1wi3xi 21 6 distinct distinct JJ cord-016990-ot1wi3xi 21 7 cytopathology cytopathology NN cord-016990-ot1wi3xi 21 8 or or CC cord-016990-ot1wi3xi 21 9 inclusions inclusion NNS cord-016990-ot1wi3xi 21 10 ( ( -LRB- cord-016990-ot1wi3xi 21 11 e.g. e.g. RB cord-016990-ot1wi3xi 21 12 , , , cord-016990-ot1wi3xi 21 13 adenoviruses adenovirus NNS cord-016990-ot1wi3xi 21 14 , , , cord-016990-ot1wi3xi 21 15 herpesviruses herpesviruses NNP cord-016990-ot1wi3xi 21 16 , , , cord-016990-ot1wi3xi 21 17 and and CC cord-016990-ot1wi3xi 21 18 paramyxoviruses paramyxoviruses NNP cord-016990-ot1wi3xi 21 19 ) ) -RRB- cord-016990-ot1wi3xi 21 20 , , , cord-016990-ot1wi3xi 21 21 many many JJ cord-016990-ot1wi3xi 21 22 important important JJ cord-016990-ot1wi3xi 21 23 pathogens pathogen NNS cord-016990-ot1wi3xi 21 24 ( ( -LRB- cord-016990-ot1wi3xi 21 25 e.g. e.g. RB cord-016990-ot1wi3xi 21 26 , , , cord-016990-ot1wi3xi 21 27 influenza influenza NN cord-016990-ot1wi3xi 21 28 viruses virus NNS cord-016990-ot1wi3xi 21 29 ) ) -RRB- cord-016990-ot1wi3xi 21 30 do do VBP cord-016990-ot1wi3xi 21 31 not not RB cord-016990-ot1wi3xi 21 32 , , , cord-016990-ot1wi3xi 21 33 and and CC cord-016990-ot1wi3xi 21 34 none none NN cord-016990-ot1wi3xi 21 35 of of IN cord-016990-ot1wi3xi 21 36 these these DT cord-016990-ot1wi3xi 21 37 agents agent NNS cord-016990-ot1wi3xi 21 38 are be VBP cord-016990-ot1wi3xi 21 39 resolved resolve VBN cord-016990-ot1wi3xi 21 40 specifically specifically RB cord-016990-ot1wi3xi 21 41 in in IN cord-016990-ot1wi3xi 21 42 tissue tissue NN cord-016990-ot1wi3xi 21 43 by by IN cord-016990-ot1wi3xi 21 44 routine routine JJ cord-016990-ot1wi3xi 21 45 histologic histologic JJ cord-016990-ot1wi3xi 21 46 stains stain NNS cord-016990-ot1wi3xi 21 47 . . . cord-016990-ot1wi3xi 22 1 Viruses virus NNS cord-016990-ot1wi3xi 22 2 require require VBP cord-016990-ot1wi3xi 22 3 live live JJ cord-016990-ot1wi3xi 22 4 cells cell NNS cord-016990-ot1wi3xi 22 5 for for IN cord-016990-ot1wi3xi 22 6 cultivation cultivation NN cord-016990-ot1wi3xi 22 7 , , , cord-016990-ot1wi3xi 22 8 and and CC cord-016990-ot1wi3xi 22 9 are be VBP cord-016990-ot1wi3xi 22 10 generally generally RB cord-016990-ot1wi3xi 22 11 more more RBR cord-016990-ot1wi3xi 22 12 difficult difficult JJ cord-016990-ot1wi3xi 22 13 than than IN cord-016990-ot1wi3xi 22 14 bacteria bacteria NNS cord-016990-ot1wi3xi 22 15 to to TO cord-016990-ot1wi3xi 22 16 isolate isolate VB cord-016990-ot1wi3xi 22 17 from from IN cord-016990-ot1wi3xi 22 18 clinical clinical JJ cord-016990-ot1wi3xi 22 19 samples sample NNS cord-016990-ot1wi3xi 22 20 . . . cord-016990-ot1wi3xi 23 1 For for IN cord-016990-ot1wi3xi 23 2 some some DT cord-016990-ot1wi3xi 23 3 viral viral JJ cord-016990-ot1wi3xi 23 4 pneumonias pneumonia NNS cord-016990-ot1wi3xi 23 5 , , , cord-016990-ot1wi3xi 23 6 426 426 CD cord-016990-ot1wi3xi 23 7 the the DT cord-016990-ot1wi3xi 23 8 pathogen pathogen NN cord-016990-ot1wi3xi 23 9 appears appear VBZ cord-016990-ot1wi3xi 23 10 to to TO cord-016990-ot1wi3xi 23 11 initiate initiate VB cord-016990-ot1wi3xi 23 12 a a DT cord-016990-ot1wi3xi 23 13 cascade cascade NN cord-016990-ot1wi3xi 23 14 of of IN cord-016990-ot1wi3xi 23 15 destructive destructive JJ cord-016990-ot1wi3xi 23 16 host host NN cord-016990-ot1wi3xi 23 17 responses response NNS cord-016990-ot1wi3xi 23 18 that that WDT cord-016990-ot1wi3xi 23 19 continue continue VBP cord-016990-ot1wi3xi 23 20 or or CC cord-016990-ot1wi3xi 23 21 progress progress VB cord-016990-ot1wi3xi 23 22 even even RB cord-016990-ot1wi3xi 23 23 in in IN cord-016990-ot1wi3xi 23 24 the the DT cord-016990-ot1wi3xi 23 25 absence absence NN cord-016990-ot1wi3xi 23 26 of of IN cord-016990-ot1wi3xi 23 27 the the DT cord-016990-ot1wi3xi 23 28 specific specific JJ cord-016990-ot1wi3xi 23 29 infectious infectious JJ cord-016990-ot1wi3xi 23 30 agent agent NN cord-016990-ot1wi3xi 23 31 , , , cord-016990-ot1wi3xi 23 32 and and CC cord-016990-ot1wi3xi 23 33 in in IN cord-016990-ot1wi3xi 23 34 these these DT cord-016990-ot1wi3xi 23 35 patients patient NNS cord-016990-ot1wi3xi 23 36 the the DT cord-016990-ot1wi3xi 23 37 etiologic etiologic JJ cord-016990-ot1wi3xi 23 38 agent agent NN cord-016990-ot1wi3xi 23 39 may may MD cord-016990-ot1wi3xi 23 40 be be VB cord-016990-ot1wi3xi 23 41 absent absent JJ cord-016990-ot1wi3xi 23 42 from from IN cord-016990-ot1wi3xi 23 43 host host NN cord-016990-ot1wi3xi 23 44 tissues tissue NNS cord-016990-ot1wi3xi 23 45 at at IN cord-016990-ot1wi3xi 23 46 the the DT cord-016990-ot1wi3xi 23 47 time time NN cord-016990-ot1wi3xi 23 48 of of IN cord-016990-ot1wi3xi 23 49 autopsy.13 autopsy.13 NNP cord-016990-ot1wi3xi 23 50 Thirty Thirty NNP cord-016990-ot1wi3xi 23 51 to to IN cord-016990-ot1wi3xi 23 52 sixty sixty CD cord-016990-ot1wi3xi 23 53 percent percent NN cord-016990-ot1wi3xi 23 54 of of IN cord-016990-ot1wi3xi 23 55 community community NN cord-016990-ot1wi3xi 23 56 - - HYPH cord-016990-ot1wi3xi 23 57 acquired acquire VBN cord-016990-ot1wi3xi 23 58 pneumonias pneumonia NNS cord-016990-ot1wi3xi 23 59 are be VBP cord-016990-ot1wi3xi 23 60 etiologically etiologically RB cord-016990-ot1wi3xi 23 61 undetermined undetermined JJ cord-016990-ot1wi3xi 23 62 , , , cord-016990-ot1wi3xi 23 63 14 14 CD cord-016990-ot1wi3xi 23 64 and and CC cord-016990-ot1wi3xi 23 65 it -PRON- PRP cord-016990-ot1wi3xi 23 66 is be VBZ cord-016990-ot1wi3xi 23 67 entirely entirely RB cord-016990-ot1wi3xi 23 68 possible possible JJ cord-016990-ot1wi3xi 23 69 that that IN cord-016990-ot1wi3xi 23 70 viruses virus NNS cord-016990-ot1wi3xi 23 71 directly directly RB cord-016990-ot1wi3xi 23 72 cause cause VBP cord-016990-ot1wi3xi 23 73 more more JJR cord-016990-ot1wi3xi 23 74 episodes episode NNS cord-016990-ot1wi3xi 23 75 of of IN cord-016990-ot1wi3xi 23 76 pneumonia pneumonia NN cord-016990-ot1wi3xi 23 77 than than IN cord-016990-ot1wi3xi 23 78 currently currently RB cord-016990-ot1wi3xi 23 79 appreciated appreciate VBN cord-016990-ot1wi3xi 23 80 . . . cord-016990-ot1wi3xi 24 1 Because because IN cord-016990-ot1wi3xi 24 2 viral viral JJ cord-016990-ot1wi3xi 24 3 infections infection NNS cord-016990-ot1wi3xi 24 4 of of IN cord-016990-ot1wi3xi 24 5 the the DT cord-016990-ot1wi3xi 24 6 lower low JJR cord-016990-ot1wi3xi 24 7 respiratory respiratory JJ cord-016990-ot1wi3xi 24 8 tract tract NN cord-016990-ot1wi3xi 24 9 often often RB cord-016990-ot1wi3xi 24 10 precede precede VBP cord-016990-ot1wi3xi 24 11 bacterial bacterial JJ cord-016990-ot1wi3xi 24 12 pneumonias pneumonia NNS cord-016990-ot1wi3xi 24 13 , , , cord-016990-ot1wi3xi 24 14 viruses virus NNS cord-016990-ot1wi3xi 24 15 may may MD cord-016990-ot1wi3xi 24 16 indirectly indirectly RB cord-016990-ot1wi3xi 24 17 exert exert VB cord-016990-ot1wi3xi 24 18 considerable considerable JJ cord-016990-ot1wi3xi 24 19 influence influence NN cord-016990-ot1wi3xi 24 20 on on IN cord-016990-ot1wi3xi 24 21 the the DT cord-016990-ot1wi3xi 24 22 cumulative cumulative JJ cord-016990-ot1wi3xi 24 23 morbidity morbidity NN cord-016990-ot1wi3xi 24 24 and and CC cord-016990-ot1wi3xi 24 25 mortality mortality NN cord-016990-ot1wi3xi 24 26 of of IN cord-016990-ot1wi3xi 24 27 infectious infectious JJ cord-016990-ot1wi3xi 24 28 pneumonias pneumonia NNS cord-016990-ot1wi3xi 24 29 . . . cord-016990-ot1wi3xi 25 1 15 15 CD cord-016990-ot1wi3xi 25 2 , , , cord-016990-ot1wi3xi 25 3 16 16 CD cord-016990-ot1wi3xi 26 1 The the DT cord-016990-ot1wi3xi 26 2 mechanisms mechanism NNS cord-016990-ot1wi3xi 26 3 by by IN cord-016990-ot1wi3xi 26 4 which which WDT cord-016990-ot1wi3xi 26 5 viruses virus NNS cord-016990-ot1wi3xi 26 6 may may MD cord-016990-ot1wi3xi 26 7 facilitate facilitate VB cord-016990-ot1wi3xi 26 8 bacterial bacterial JJ cord-016990-ot1wi3xi 26 9 invasion invasion NN cord-016990-ot1wi3xi 26 10 of of IN cord-016990-ot1wi3xi 26 11 the the DT cord-016990-ot1wi3xi 26 12 respiratory respiratory JJ cord-016990-ot1wi3xi 26 13 tract tract NN cord-016990-ot1wi3xi 26 14 are be VBP cord-016990-ot1wi3xi 26 15 complex complex JJ cord-016990-ot1wi3xi 26 16 and and CC cord-016990-ot1wi3xi 26 17 varied varied JJ cord-016990-ot1wi3xi 26 18 . . . cord-016990-ot1wi3xi 27 1 Certain certain JJ cord-016990-ot1wi3xi 27 2 viruses virus NNS cord-016990-ot1wi3xi 27 3 cause cause VBP cord-016990-ot1wi3xi 27 4 the the DT cord-016990-ot1wi3xi 27 5 death death NN cord-016990-ot1wi3xi 27 6 of of IN cord-016990-ot1wi3xi 27 7 ciliated ciliated JJ cord-016990-ot1wi3xi 27 8 respiratory respiratory JJ cord-016990-ot1wi3xi 27 9 epithelium epithelium NN cord-016990-ot1wi3xi 27 10 and and CC cord-016990-ot1wi3xi 27 11 thereby thereby RB cord-016990-ot1wi3xi 27 12 disrupt disrupt VB cord-016990-ot1wi3xi 27 13 normal normal JJ cord-016990-ot1wi3xi 27 14 ciliary ciliary NN cord-016990-ot1wi3xi 27 15 activity activity NN cord-016990-ot1wi3xi 27 16 . . . cord-016990-ot1wi3xi 28 1 Viruses virus NNS cord-016990-ot1wi3xi 28 2 may may MD cord-016990-ot1wi3xi 28 3 also also RB cord-016990-ot1wi3xi 28 4 inhibit inhibit VB cord-016990-ot1wi3xi 28 5 the the DT cord-016990-ot1wi3xi 28 6 phagocytic phagocytic JJ cord-016990-ot1wi3xi 28 7 or or CC cord-016990-ot1wi3xi 28 8 bactericidal bactericidal JJ cord-016990-ot1wi3xi 28 9 activities activity NNS cord-016990-ot1wi3xi 28 10 of of IN cord-016990-ot1wi3xi 28 11 neutrophils neutrophil NNS cord-016990-ot1wi3xi 28 12 , , , cord-016990-ot1wi3xi 28 13 T t NN cord-016990-ot1wi3xi 28 14 lymphocytes lymphocyte NNS cord-016990-ot1wi3xi 28 15 , , , cord-016990-ot1wi3xi 28 16 and and CC cord-016990-ot1wi3xi 28 17 alveolar alveolar JJ cord-016990-ot1wi3xi 28 18 macrophages macrophage NNS cord-016990-ot1wi3xi 28 19 , , , cord-016990-ot1wi3xi 28 20 and and CC cord-016990-ot1wi3xi 28 21 predispose predispose VB cord-016990-ot1wi3xi 28 22 the the DT cord-016990-ot1wi3xi 28 23 host host NN cord-016990-ot1wi3xi 28 24 to to IN cord-016990-ot1wi3xi 28 25 secondary secondary JJ cord-016990-ot1wi3xi 28 26 infections infection NNS cord-016990-ot1wi3xi 28 27 . . . cord-016990-ot1wi3xi 29 1 Certain certain JJ cord-016990-ot1wi3xi 29 2 gram gram NN cord-016990-ot1wi3xi 29 3 - - HYPH cord-016990-ot1wi3xi 29 4 positive positive JJ cord-016990-ot1wi3xi 29 5 and and CC cord-016990-ot1wi3xi 29 6 gram gram JJ cord-016990-ot1wi3xi 29 7 - - HYPH cord-016990-ot1wi3xi 29 8 negative negative JJ cord-016990-ot1wi3xi 29 9 bacteria bacteria NNS cord-016990-ot1wi3xi 29 10 adhere adhere VBP cord-016990-ot1wi3xi 29 11 to to IN cord-016990-ot1wi3xi 29 12 and and CC cord-016990-ot1wi3xi 29 13 colonize colonize VB cord-016990-ot1wi3xi 29 14 virus virus NN cord-016990-ot1wi3xi 29 15 - - HYPH cord-016990-ot1wi3xi 29 16 infected infect VBN cord-016990-ot1wi3xi 29 17 epithelium epithelium NN cord-016990-ot1wi3xi 29 18 more more RBR cord-016990-ot1wi3xi 29 19 readily readily RB cord-016990-ot1wi3xi 29 20 than than IN cord-016990-ot1wi3xi 29 21 to to IN cord-016990-ot1wi3xi 29 22 noninfected noninfected JJ cord-016990-ot1wi3xi 29 23 cells cell NNS cord-016990-ot1wi3xi 29 24 by by IN cord-016990-ot1wi3xi 29 25 various various JJ cord-016990-ot1wi3xi 29 26 hypothetical hypothetical JJ cord-016990-ot1wi3xi 29 27 mechanisms mechanism NNS cord-016990-ot1wi3xi 29 28 , , , cord-016990-ot1wi3xi 29 29 including include VBG cord-016990-ot1wi3xi 29 30 alteration alteration NN cord-016990-ot1wi3xi 29 31 and and CC cord-016990-ot1wi3xi 29 32 induction induction NN cord-016990-ot1wi3xi 29 33 of of IN cord-016990-ot1wi3xi 29 34 receptors receptor NNS cord-016990-ot1wi3xi 29 35 at at IN cord-016990-ot1wi3xi 29 36 the the DT cord-016990-ot1wi3xi 29 37 host host NN cord-016990-ot1wi3xi 29 38 - - HYPH cord-016990-ot1wi3xi 29 39 cell cell NN cord-016990-ot1wi3xi 29 40 surface surface NN cord-016990-ot1wi3xi 29 41 and and CC cord-016990-ot1wi3xi 29 42 changes change NNS cord-016990-ot1wi3xi 29 43 in in IN cord-016990-ot1wi3xi 29 44 the the DT cord-016990-ot1wi3xi 29 45 extracellular extracellular JJ cord-016990-ot1wi3xi 29 46 environmentY-19 environmenty-19 NN cord-016990-ot1wi3xi 29 47 Finally finally RB cord-016990-ot1wi3xi 29 48 , , , cord-016990-ot1wi3xi 29 49 viral viral JJ cord-016990-ot1wi3xi 29 50 infections infection NNS cord-016990-ot1wi3xi 29 51 of of IN cord-016990-ot1wi3xi 29 52 the the DT cord-016990-ot1wi3xi 29 53 lung lung NN cord-016990-ot1wi3xi 29 54 may may MD cord-016990-ot1wi3xi 29 55 exacerbate exacerbate VB cord-016990-ot1wi3xi 29 56 noninfectious noninfectious JJ cord-016990-ot1wi3xi 29 57 pulmonary pulmonary JJ cord-016990-ot1wi3xi 29 58 conditions condition NNS cord-016990-ot1wi3xi 29 59 ( ( -LRB- cord-016990-ot1wi3xi 29 60 e.g. e.g. RB cord-016990-ot1wi3xi 29 61 , , , cord-016990-ot1wi3xi 29 62 asthma asthma NN cord-016990-ot1wi3xi 29 63 and and CC cord-016990-ot1wi3xi 29 64 chronic chronic JJ cord-016990-ot1wi3xi 29 65 obstructive obstructive JJ cord-016990-ot1wi3xi 29 66 pulmonary pulmonary JJ cord-016990-ot1wi3xi 29 67 disease disease NN cord-016990-ot1wi3xi 29 68 ) ) -RRB- cord-016990-ot1wi3xi 29 69 and and CC cord-016990-ot1wi3xi 29 70 indirectly indirectly RB cord-016990-ot1wi3xi 29 71 contribute contribute VB cord-016990-ot1wi3xi 29 72 to to IN cord-016990-ot1wi3xi 29 73 aggregate aggregate JJ cord-016990-ot1wi3xi 29 74 morbidity morbidity NN cord-016990-ot1wi3xi 29 75 and and CC cord-016990-ot1wi3xi 29 76 mortality mortality NN cord-016990-ot1wi3xi 29 77 associated associate VBN cord-016990-ot1wi3xi 29 78 with with IN cord-016990-ot1wi3xi 29 79 these these DT cord-016990-ot1wi3xi 29 80 conditions condition NNS cord-016990-ot1wi3xi 29 81 . . . cord-016990-ot1wi3xi 30 1 20 20 CD cord-016990-ot1wi3xi 31 1 Although although IN cord-016990-ot1wi3xi 31 2 influenza influenza NN cord-016990-ot1wi3xi 31 3 viruses virus NNS cord-016990-ot1wi3xi 31 4 remain remain VBP cord-016990-ot1wi3xi 31 5 the the DT cord-016990-ot1wi3xi 31 6 most most RBS cord-016990-ot1wi3xi 31 7 frequently frequently RB cord-016990-ot1wi3xi 31 8 identified identify VBN cord-016990-ot1wi3xi 31 9 cause cause NN cord-016990-ot1wi3xi 31 10 of of IN cord-016990-ot1wi3xi 31 11 viral viral JJ cord-016990-ot1wi3xi 31 12 pneumonia pneumonia NN cord-016990-ot1wi3xi 31 13 in in IN cord-016990-ot1wi3xi 31 14 adults adult NNS cord-016990-ot1wi3xi 31 15 ( ( -LRB- cord-016990-ot1wi3xi 31 16 Table table NN cord-016990-ot1wi3xi 31 17 11 11 CD cord-016990-ot1wi3xi 31 18 .1 .1 CD cord-016990-ot1wi3xi 31 19 ) ) -RRB- cord-016990-ot1wi3xi 31 20 , , , cord-016990-ot1wi3xi 31 21 the the DT cord-016990-ot1wi3xi 31 22 diversity diversity NN cord-016990-ot1wi3xi 31 23 of of IN cord-016990-ot1wi3xi 31 24 agents agent NNS cord-016990-ot1wi3xi 31 25 identified identify VBN cord-016990-ot1wi3xi 31 26 as as IN cord-016990-ot1wi3xi 31 27 causes cause NNS cord-016990-ot1wi3xi 31 28 of of IN cord-016990-ot1wi3xi 31 29 viral viral JJ cord-016990-ot1wi3xi 31 30 pneumonias pneumonia NNS cord-016990-ot1wi3xi 31 31 has have VBZ cord-016990-ot1wi3xi 31 32 expanded expand VBN cord-016990-ot1wi3xi 31 33 considerably considerably RB cord-016990-ot1wi3xi 31 34 . . . cord-016990-ot1wi3xi 32 1 Several several JJ cord-016990-ot1wi3xi 32 2 newly newly RB cord-016990-ot1wi3xi 32 3 recognized recognize VBN cord-016990-ot1wi3xi 32 4 viral viral JJ cord-016990-ot1wi3xi 32 5 pneumonias pneumonia NNS cord-016990-ot1wi3xi 32 6 have have VBP cord-016990-ot1wi3xi 32 7 been be VBN cord-016990-ot1wi3xi 32 8 identified identify VBN cord-016990-ot1wi3xi 32 9 since since IN cord-016990-ot1wi3xi 32 10 1992 1992 CD cord-016990-ot1wi3xi 32 11 that that WDT cord-016990-ot1wi3xi 32 12 are be VBP cord-016990-ot1wi3xi 32 13 among among IN cord-016990-ot1wi3xi 32 14 the the DT cord-016990-ot1wi3xi 32 15 most most RBS cord-016990-ot1wi3xi 32 16 feared feared JJ cord-016990-ot1wi3xi 32 17 and and CC cord-016990-ot1wi3xi 32 18 lethal lethal JJ cord-016990-ot1wi3xi 32 19 of of IN cord-016990-ot1wi3xi 32 20 all all DT cord-016990-ot1wi3xi 32 21 emerging emerge VBG cord-016990-ot1wi3xi 32 22 infections infection NNS cord-016990-ot1wi3xi 32 23 , , , cord-016990-ot1wi3xi 32 24 including include VBG cord-016990-ot1wi3xi 32 25 those those DT cord-016990-ot1wi3xi 32 26 caused cause VBN cord-016990-ot1wi3xi 32 27 by by IN cord-016990-ot1wi3xi 32 28 hantaviruses hantaviruse NNS cord-016990-ot1wi3xi 32 29 , , , cord-016990-ot1wi3xi 32 30 Nipah Nipah NNP cord-016990-ot1wi3xi 32 31 virus virus NN cord-016990-ot1wi3xi 32 32 , , , cord-016990-ot1wi3xi 32 33 and and CC cord-016990-ot1wi3xi 32 34 SARS SARS NNP cord-016990-ot1wi3xi 32 35 corona corona NNP cord-016990-ot1wi3xi 32 36 virus virus NN cord-016990-ot1wi3xi 32 37 ( ( -LRB- cord-016990-ot1wi3xi 32 38 Co Co NNP cord-016990-ot1wi3xi 32 39 V V NNP cord-016990-ot1wi3xi 32 40 ) ) -RRB- cord-016990-ot1wi3xi 32 41 . . . cord-016990-ot1wi3xi 32 42 ! ! . cord-016990-ot1wi3xi 33 1 3,21 3,21 CD cord-016990-ot1wi3xi 33 2 - - SYM cord-016990-ot1wi3xi 33 3 23 23 CD cord-016990-ot1wi3xi 34 1 Certain certain JJ cord-016990-ot1wi3xi 34 2 causes cause NNS cord-016990-ot1wi3xi 34 3 " " `` cord-016990-ot1wi3xi 34 4 Rubella rubella NN cord-016990-ot1wi3xi 34 5 ( ( -LRB- cord-016990-ot1wi3xi 34 6 2 2 CD cord-016990-ot1wi3xi 34 7 ) ) -RRB- cord-016990-ot1wi3xi 34 8 , , , cord-016990-ot1wi3xi 34 9 rhinovirus rhinovirus NN cord-016990-ot1wi3xi 34 10 ( ( -LRB- cord-016990-ot1wi3xi 34 11 1 1 CD cord-016990-ot1wi3xi 34 12 ) ) -RRB- cord-016990-ot1wi3xi 34 13 , , , cord-016990-ot1wi3xi 34 14 mixed mix VBN cord-016990-ot1wi3xi 34 15 viral viral JJ cord-016990-ot1wi3xi 34 16 infections infection NNS cord-016990-ot1wi3xi 34 17 ( ( -LRB- cord-016990-ot1wi3xi 34 18 3 3 CD cord-016990-ot1wi3xi 34 19 ) ) -RRB- cord-016990-ot1wi3xi 34 20 . . . cord-016990-ot1wi3xi 35 1 Source source NN cord-016990-ot1wi3xi 35 2 : : : cord-016990-ot1wi3xi 36 1 Adapted adapt VBN cord-016990-ot1wi3xi 36 2 from from IN cord-016990-ot1wi3xi 36 3 Greenberg Greenberg NNP cord-016990-ot1wi3xi 36 4 . . . cord-016990-ot1wi3xi 37 1 6 6 CD cord-016990-ot1wi3xi 37 2 of of IN cord-016990-ot1wi3xi 37 3 viral viral JJ cord-016990-ot1wi3xi 37 4 pneumonia pneumonia NN cord-016990-ot1wi3xi 37 5 , , , cord-016990-ot1wi3xi 37 6 particularly particularly RB cord-016990-ot1wi3xi 37 7 those those DT cord-016990-ot1wi3xi 37 8 that that WDT cord-016990-ot1wi3xi 37 9 occur occur VBP cord-016990-ot1wi3xi 37 10 in in IN cord-016990-ot1wi3xi 37 11 vulnerable vulnerable JJ cord-016990-ot1wi3xi 37 12 patient patient JJ cord-016990-ot1wi3xi 37 13 cohorts cohort NNS cord-016990-ot1wi3xi 37 14 , , , cord-016990-ot1wi3xi 37 15 have have VBP cord-016990-ot1wi3xi 37 16 diminished diminish VBN cord-016990-ot1wi3xi 37 17 during during IN cord-016990-ot1wi3xi 37 18 this this DT cord-016990-ot1wi3xi 37 19 same same JJ cord-016990-ot1wi3xi 37 20 interval interval NN cord-016990-ot1wi3xi 37 21 . . . cord-016990-ot1wi3xi 38 1 By by IN cord-016990-ot1wi3xi 38 2 example example NN cord-016990-ot1wi3xi 38 3 , , , cord-016990-ot1wi3xi 38 4 the the DT cord-016990-ot1wi3xi 38 5 U.S. U.S. NNP cord-016990-ot1wi3xi 38 6 incidence incidence NN cord-016990-ot1wi3xi 38 7 of of IN cord-016990-ot1wi3xi 38 8 varicella varicella NN cord-016990-ot1wi3xi 38 9 pneumonia pneumonia NN cord-016990-ot1wi3xi 38 10 has have VBZ cord-016990-ot1wi3xi 38 11 dropped drop VBN cord-016990-ot1wi3xi 38 12 by by IN cord-016990-ot1wi3xi 38 13 two two CD cord-016990-ot1wi3xi 38 14 thirds third NNS cord-016990-ot1wi3xi 38 15 since since IN cord-016990-ot1wi3xi 38 16 universal universal JJ cord-016990-ot1wi3xi 38 17 childhood childhood NN cord-016990-ot1wi3xi 38 18 vaccination vaccination NN cord-016990-ot1wi3xi 38 19 for for IN cord-016990-ot1wi3xi 38 20 varicella varicella NN cord-016990-ot1wi3xi 38 21 was be VBD cord-016990-ot1wi3xi 38 22 implemented implement VBN cord-016990-ot1wi3xi 38 23 in in IN cord-016990-ot1wi3xi 38 24 1995 1995 CD cord-016990-ot1wi3xi 38 25 , , , cord-016990-ot1wi3xi 38 26 24 24 CD cord-016990-ot1wi3xi 38 27 , , , cord-016990-ot1wi3xi 38 28 25 25 CD cord-016990-ot1wi3xi 38 29 and and CC cord-016990-ot1wi3xi 38 30 advances advance NNS cord-016990-ot1wi3xi 38 31 in in IN cord-016990-ot1wi3xi 38 32 the the DT cord-016990-ot1wi3xi 38 33 clinical clinical JJ cord-016990-ot1wi3xi 38 34 management management NN cord-016990-ot1wi3xi 38 35 of of IN cord-016990-ot1wi3xi 38 36 transplant transplant NN cord-016990-ot1wi3xi 38 37 recipients recipient NNS cord-016990-ot1wi3xi 38 38 have have VBP cord-016990-ot1wi3xi 38 39 reduced reduce VBN cord-016990-ot1wi3xi 38 40 the the DT cord-016990-ot1wi3xi 38 41 incidence incidence NN cord-016990-ot1wi3xi 38 42 of of IN cord-016990-ot1wi3xi 38 43 cytomegalovirus cytomegalovirus NNP cord-016990-ot1wi3xi 38 44 ( ( -LRB- cord-016990-ot1wi3xi 38 45 CMV CMV NNP cord-016990-ot1wi3xi 38 46 ) ) -RRB- cord-016990-ot1wi3xi 39 1 pneumonia?6 pneumonia?6 NNP cord-016990-ot1wi3xi 39 2 Also also RB cord-016990-ot1wi3xi 39 3 occurring occur VBG cord-016990-ot1wi3xi 39 4 during during IN cord-016990-ot1wi3xi 39 5 the the DT cord-016990-ot1wi3xi 39 6 last last JJ cord-016990-ot1wi3xi 39 7 decade decade NN cord-016990-ot1wi3xi 39 8 has have VBZ cord-016990-ot1wi3xi 39 9 been be VBN cord-016990-ot1wi3xi 39 10 the the DT cord-016990-ot1wi3xi 39 11 development development NN cord-016990-ot1wi3xi 39 12 and and CC cord-016990-ot1wi3xi 39 13 use use NN cord-016990-ot1wi3xi 39 14 of of IN cord-016990-ot1wi3xi 39 15 powerful powerful JJ cord-016990-ot1wi3xi 39 16 molecular molecular JJ cord-016990-ot1wi3xi 39 17 techniques technique NNS cord-016990-ot1wi3xi 39 18 that that WDT cord-016990-ot1wi3xi 39 19 have have VBP cord-016990-ot1wi3xi 39 20 unveiled unveil VBN cord-016990-ot1wi3xi 39 21 the the DT cord-016990-ot1wi3xi 39 22 identity identity NN cord-016990-ot1wi3xi 39 23 of of IN cord-016990-ot1wi3xi 39 24 historic historic JJ cord-016990-ot1wi3xi 39 25 pathogens pathogen NNS cord-016990-ot1wi3xi 39 26 ( ( -LRB- cord-016990-ot1wi3xi 39 27 e.g. e.g. RB cord-016990-ot1wi3xi 39 28 , , , cord-016990-ot1wi3xi 39 29 the the DT cord-016990-ot1wi3xi 39 30 HINI HINI NNP cord-016990-ot1wi3xi 39 31 " " `` cord-016990-ot1wi3xi 39 32 Spanish spanish JJ cord-016990-ot1wi3xi 39 33 " " '' cord-016990-ot1wi3xi 39 34 influenza influenza NN cord-016990-ot1wi3xi 39 35 A a DT cord-016990-ot1wi3xi 39 36 virus),27.28 virus),27.28 NN cord-016990-ot1wi3xi 39 37 and and CC cord-016990-ot1wi3xi 39 38 have have VBP cord-016990-ot1wi3xi 39 39 facilitated facilitate VBN cord-016990-ot1wi3xi 39 40 the the DT cord-016990-ot1wi3xi 39 41 rapid rapid JJ cord-016990-ot1wi3xi 39 42 characterization characterization NN cord-016990-ot1wi3xi 39 43 of of IN cord-016990-ot1wi3xi 39 44 emerging emerge VBG cord-016990-ot1wi3xi 39 45 agents agent NNS cord-016990-ot1wi3xi 39 46 ( ( -LRB- cord-016990-ot1wi3xi 39 47 e.g. e.g. RB cord-016990-ot1wi3xi 39 48 , , , cord-016990-ot1wi3xi 39 49 SARS SARS NNP cord-016990-ot1wi3xi 39 50 - - HYPH cord-016990-ot1wi3xi 39 51 Co Co NNP cord-016990-ot1wi3xi 39 52 V v NN cord-016990-ot1wi3xi 39 53 ) ) -RRB- cord-016990-ot1wi3xi 39 54 . . . cord-016990-ot1wi3xi 40 1 13 13 CD cord-016990-ot1wi3xi 41 1 It -PRON- PRP cord-016990-ot1wi3xi 41 2 should should MD cord-016990-ot1wi3xi 41 3 be be VB cord-016990-ot1wi3xi 41 4 noted note VBN cord-016990-ot1wi3xi 41 5 that that IN cord-016990-ot1wi3xi 41 6 the the DT cord-016990-ot1wi3xi 41 7 disease disease NN cord-016990-ot1wi3xi 41 8 manifestations manifestation NNS cord-016990-ot1wi3xi 41 9 of of IN cord-016990-ot1wi3xi 41 10 several several JJ cord-016990-ot1wi3xi 41 11 of of IN cord-016990-ot1wi3xi 41 12 these these DT cord-016990-ot1wi3xi 41 13 agents agent NNS cord-016990-ot1wi3xi 41 14 ( ( -LRB- cord-016990-ot1wi3xi 41 15 e.g. e.g. RB cord-016990-ot1wi3xi 41 16 , , , cord-016990-ot1wi3xi 41 17 human human JJ cord-016990-ot1wi3xi 41 18 parainfluenza parainfluenza NN cord-016990-ot1wi3xi 41 19 virus virus NN cord-016990-ot1wi3xi 41 20 [ [ -LRB- cord-016990-ot1wi3xi 41 21 HPIV HPIV NNP cord-016990-ot1wi3xi 41 22 ] ] -RRB- cord-016990-ot1wi3xi 41 23 , , , cord-016990-ot1wi3xi 41 24 respiratory respiratory JJ cord-016990-ot1wi3xi 41 25 syncytial syncytial JJ cord-016990-ot1wi3xi 41 26 virus virus NN cord-016990-ot1wi3xi 41 27 [ [ -LRB- cord-016990-ot1wi3xi 41 28 RSV RSV NNP cord-016990-ot1wi3xi 41 29 ] ] -RRB- cord-016990-ot1wi3xi 41 30 , , , cord-016990-ot1wi3xi 41 31 and and CC cord-016990-ot1wi3xi 41 32 influenza influenza NN cord-016990-ot1wi3xi 41 33 ) ) -RRB- cord-016990-ot1wi3xi 41 34 are be VBP cord-016990-ot1wi3xi 41 35 often often RB cord-016990-ot1wi3xi 41 36 confined confine VBN cord-016990-ot1wi3xi 41 37 to to IN cord-016990-ot1wi3xi 41 38 the the DT cord-016990-ot1wi3xi 41 39 upper upper JJ cord-016990-ot1wi3xi 41 40 airway airway NN cord-016990-ot1wi3xi 41 41 and and CC cord-016990-ot1wi3xi 41 42 are be VBP cord-016990-ot1wi3xi 41 43 not not RB cord-016990-ot1wi3xi 41 44 invari- invari- JJ cord-016990-ot1wi3xi 42 1 AorB AorB NNP cord-016990-ot1wi3xi 42 2 _SP cord-016990-ot1wi3xi 43 1 RSV RSV NNP cord-016990-ot1wi3xi 43 2 _SP cord-016990-ot1wi3xi 43 3 HPIV HPIV NNP cord-016990-ot1wi3xi 43 4 _SP cord-016990-ot1wi3xi 44 1 Adeno Adeno NNP cord-016990-ot1wi3xi 44 2 _SP cord-016990-ot1wi3xi 45 1 CMV CMV NNP cord-016990-ot1wi3xi 45 2 _SP cord-016990-ot1wi3xi 46 1 Varicella Varicella NNP cord-016990-ot1wi3xi 46 2 _SP cord-016990-ot1wi3xi 47 1 Other other JJ cord-016990-ot1wi3xi 47 2 ' ' `` cord-016990-ot1wi3xi 47 3 _SP cord-016990-ot1wi3xi 47 4 10 10 CD cord-016990-ot1wi3xi 47 5 _SP cord-016990-ot1wi3xi 47 6 0 0 CD cord-016990-ot1wi3xi 47 7 _SP cord-016990-ot1wi3xi 47 8 3 3 CD cord-016990-ot1wi3xi 47 9 _SP cord-016990-ot1wi3xi 47 10 0 0 CD cord-016990-ot1wi3xi 47 11 _SP cord-016990-ot1wi3xi 47 12 0 0 CD cord-016990-ot1wi3xi 47 13 _SP cord-016990-ot1wi3xi 47 14 3 3 CD cord-016990-ot1wi3xi 47 15 _SP cord-016990-ot1wi3xi 47 16 27 27 CD cord-016990-ot1wi3xi 47 17 _SP cord-016990-ot1wi3xi 47 18 1 1 CD cord-016990-ot1wi3xi 47 19 _SP cord-016990-ot1wi3xi 47 20 4 4 CD cord-016990-ot1wi3xi 47 21 _SP cord-016990-ot1wi3xi 47 22 3 3 CD cord-016990-ot1wi3xi 47 23 _SP cord-016990-ot1wi3xi 47 24 0 0 CD cord-016990-ot1wi3xi 47 25 _SP cord-016990-ot1wi3xi 47 26 0 0 CD cord-016990-ot1wi3xi 47 27 _SP cord-016990-ot1wi3xi 47 28 0 0 CD cord-016990-ot1wi3xi 47 29 _SP cord-016990-ot1wi3xi 47 30 7 7 CD cord-016990-ot1wi3xi 47 31 _SP cord-016990-ot1wi3xi 47 32 2 2 CD cord-016990-ot1wi3xi 47 33 _SP cord-016990-ot1wi3xi 47 34 0 0 CD cord-016990-ot1wi3xi 47 35 _SP cord-016990-ot1wi3xi 47 36 0 0 CD cord-016990-ot1wi3xi 47 37 _SP cord-016990-ot1wi3xi 47 38 1 1 CD cord-016990-ot1wi3xi 47 39 _SP cord-016990-ot1wi3xi 47 40 0 0 CD cord-016990-ot1wi3xi 47 41 _SP cord-016990-ot1wi3xi 47 42 19 19 CD cord-016990-ot1wi3xi 47 43 _SP cord-016990-ot1wi3xi 47 44 5 5 CD cord-016990-ot1wi3xi 47 45 _SP cord-016990-ot1wi3xi 47 46 5 5 CD cord-016990-ot1wi3xi 47 47 _SP cord-016990-ot1wi3xi 47 48 0 0 CD cord-016990-ot1wi3xi 47 49 _SP cord-016990-ot1wi3xi 47 50 0 0 CD cord-016990-ot1wi3xi 47 51 _SP cord-016990-ot1wi3xi 47 52 1 1 CD cord-016990-ot1wi3xi 47 53 _SP cord-016990-ot1wi3xi 47 54 7 7 CD cord-016990-ot1wi3xi 47 55 _SP cord-016990-ot1wi3xi 48 1 8 8 CD cord-016990-ot1wi3xi 48 2 _SP cord-016990-ot1wi3xi 49 1 13 13 CD cord-016990-ot1wi3xi 49 2 15 15 CD cord-016990-ot1wi3xi 49 3 0 0 CD cord-016990-ot1wi3xi 49 4 0 0 CD cord-016990-ot1wi3xi 49 5 0 0 CD cord-016990-ot1wi3xi 50 1 37 37 CD cord-016990-ot1wi3xi 50 2 5 5 CD cord-016990-ot1wi3xi 50 3 11 11 CD cord-016990-ot1wi3xi 50 4 5 5 CD cord-016990-ot1wi3xi 50 5 0 0 CD cord-016990-ot1wi3xi 50 6 0 0 CD cord-016990-ot1wi3xi 50 7 3 3 CD cord-016990-ot1wi3xi 50 8 21 21 CD cord-016990-ot1wi3xi 50 9 ( ( -LRB- cord-016990-ot1wi3xi 50 10 11 11 CD cord-016990-ot1wi3xi 50 11 ) ) -RRB- cord-016990-ot1wi3xi 51 1 32 32 CD cord-016990-ot1wi3xi 51 2 ( ( -LRB- cord-016990-ot1wi3xi 51 3 16 16 CD cord-016990-ot1wi3xi 51 4 ) ) -RRB- cord-016990-ot1wi3xi 51 5 30 30 CD cord-016990-ot1wi3xi 51 6 ( ( -LRB- cord-016990-ot1wi3xi 51 7 15 15 CD cord-016990-ot1wi3xi 51 8 ) ) -RRB- cord-016990-ot1wi3xi 51 9 1 1 CD cord-016990-ot1wi3xi 51 10 ( ( -LRB- cord-016990-ot1wi3xi 51 11 0.5 0.5 CD cord-016990-ot1wi3xi 51 12 ) ) -RRB- cord-016990-ot1wi3xi 51 13 1 1 CD cord-016990-ot1wi3xi 51 14 ( ( -LRB- cord-016990-ot1wi3xi 51 15 0.5 0.5 CD cord-016990-ot1wi3xi 51 16 ) ) -RRB- cord-016990-ot1wi3xi 51 17 6 6 CD cord-016990-ot1wi3xi 51 18 ( ( -LRB- cord-016990-ot1wi3xi 51 19 3 3 LS cord-016990-ot1wi3xi 51 20 ) ) -RRB- cord-016990-ot1wi3xi 51 21 ably ably RB cord-016990-ot1wi3xi 51 22 associated associate VBD cord-016990-ot1wi3xi 51 23 with with IN cord-016990-ot1wi3xi 51 24 pneumonia pneumonia NN cord-016990-ot1wi3xi 51 25 . . . cord-016990-ot1wi3xi 52 1 With with IN cord-016990-ot1wi3xi 52 2 some some DT cord-016990-ot1wi3xi 52 3 of of IN cord-016990-ot1wi3xi 52 4 these these DT cord-016990-ot1wi3xi 52 5 pathogens pathogen NNS cord-016990-ot1wi3xi 52 6 ( ( -LRB- cord-016990-ot1wi3xi 52 7 e.g. e.g. RB cord-016990-ot1wi3xi 52 8 , , , cord-016990-ot1wi3xi 52 9 influenza influenza NN cord-016990-ot1wi3xi 52 10 viruses virus NNS cord-016990-ot1wi3xi 52 11 , , , cord-016990-ot1wi3xi 52 12 RSV RSV NNP cord-016990-ot1wi3xi 52 13 , , , cord-016990-ot1wi3xi 52 14 hantaviruses hantaviruses NNP cord-016990-ot1wi3xi 52 15 , , , cord-016990-ot1wi3xi 52 16 and and CC cord-016990-ot1wi3xi 52 17 HPIV HPIV NNP cord-016990-ot1wi3xi 52 18 viruses virus NNS cord-016990-ot1wi3xi 52 19 ) ) -RRB- cord-016990-ot1wi3xi 53 1 respiratory respiratory JJ cord-016990-ot1wi3xi 53 2 disease disease NN cord-016990-ot1wi3xi 53 3 is be VBZ cord-016990-ot1wi3xi 53 4 the the DT cord-016990-ot1wi3xi 53 5 primary primary JJ cord-016990-ot1wi3xi 53 6 manifestation manifestation NN cord-016990-ot1wi3xi 53 7 . . . cord-016990-ot1wi3xi 54 1 For for IN cord-016990-ot1wi3xi 54 2 other other JJ cord-016990-ot1wi3xi 54 3 agents agent NNS cord-016990-ot1wi3xi 54 4 , , , cord-016990-ot1wi3xi 54 5 such such JJ cord-016990-ot1wi3xi 54 6 as as IN cord-016990-ot1wi3xi 54 7 measles measle NNS cord-016990-ot1wi3xi 54 8 , , , cord-016990-ot1wi3xi 54 9 Nipah Nipah NNP cord-016990-ot1wi3xi 54 10 virus virus NN cord-016990-ot1wi3xi 54 11 , , , cord-016990-ot1wi3xi 54 12 and and CC cord-016990-ot1wi3xi 54 13 herpesviruses herpesviruses NNP cord-016990-ot1wi3xi 54 14 , , , cord-016990-ot1wi3xi 54 15 typically typically RB cord-016990-ot1wi3xi 54 16 the the DT cord-016990-ot1wi3xi 54 17 lungs lung NNS cord-016990-ot1wi3xi 54 18 are be VBP cord-016990-ot1wi3xi 54 19 involved involve VBN cord-016990-ot1wi3xi 54 20 as as IN cord-016990-ot1wi3xi 54 21 part part NN cord-016990-ot1wi3xi 54 22 of of IN cord-016990-ot1wi3xi 54 23 a a DT cord-016990-ot1wi3xi 54 24 multisystem multisystem JJ cord-016990-ot1wi3xi 54 25 syndrome syndrome NN cord-016990-ot1wi3xi 54 26 . . . cord-016990-ot1wi3xi 55 1 The the DT cord-016990-ot1wi3xi 55 2 diagnosis diagnosis NN cord-016990-ot1wi3xi 55 3 of of IN cord-016990-ot1wi3xi 55 4 viral viral JJ cord-016990-ot1wi3xi 55 5 pneumonia pneumonia NN cord-016990-ot1wi3xi 55 6 , , , cord-016990-ot1wi3xi 55 7 suspected suspect VBN cord-016990-ot1wi3xi 55 8 by by IN cord-016990-ot1wi3xi 55 9 patient patient JJ cord-016990-ot1wi3xi 55 10 history history NN cord-016990-ot1wi3xi 55 11 and and CC cord-016990-ot1wi3xi 55 12 clinical clinical JJ cord-016990-ot1wi3xi 55 13 manifestations manifestation NNS cord-016990-ot1wi3xi 55 14 , , , cord-016990-ot1wi3xi 55 15 also also RB cord-016990-ot1wi3xi 55 16 can can MD cord-016990-ot1wi3xi 55 17 be be VB cord-016990-ot1wi3xi 55 18 supported support VBN cord-016990-ot1wi3xi 55 19 histopathologically histopathologically RB cord-016990-ot1wi3xi 55 20 , , , cord-016990-ot1wi3xi 55 21 and and CC cord-016990-ot1wi3xi 55 22 the the DT cord-016990-ot1wi3xi 55 23 general general JJ cord-016990-ot1wi3xi 55 24 pattern pattern NN cord-016990-ot1wi3xi 55 25 of of IN cord-016990-ot1wi3xi 55 26 histopathologic histopathologic JJ cord-016990-ot1wi3xi 55 27 lesions lesion NNS cord-016990-ot1wi3xi 55 28 may may MD cord-016990-ot1wi3xi 55 29 suggest suggest VB cord-016990-ot1wi3xi 55 30 a a DT cord-016990-ot1wi3xi 55 31 specific specific JJ cord-016990-ot1wi3xi 55 32 diagnosis diagnosis NN cord-016990-ot1wi3xi 55 33 . . . cord-016990-ot1wi3xi 56 1 Many many JJ cord-016990-ot1wi3xi 56 2 viruses virus NNS cord-016990-ot1wi3xi 56 3 can can MD cord-016990-ot1wi3xi 56 4 be be VB cord-016990-ot1wi3xi 56 5 identified identify VBN cord-016990-ot1wi3xi 56 6 in in IN cord-016990-ot1wi3xi 56 7 lung lung NN cord-016990-ot1wi3xi 56 8 by by IN cord-016990-ot1wi3xi 56 9 examining examine VBG cord-016990-ot1wi3xi 56 10 the the DT cord-016990-ot1wi3xi 56 11 tissue tissue NN cord-016990-ot1wi3xi 56 12 response response NN cord-016990-ot1wi3xi 56 13 and and CC cord-016990-ot1wi3xi 56 14 cytopathic cytopathic JJ cord-016990-ot1wi3xi 56 15 changes change NNS cord-016990-ot1wi3xi 56 16 . . . cord-016990-ot1wi3xi 57 1 Some some DT cord-016990-ot1wi3xi 57 2 of of IN cord-016990-ot1wi3xi 57 3 these these DT cord-016990-ot1wi3xi 57 4 viruses virus NNS cord-016990-ot1wi3xi 57 5 cause cause VBP cord-016990-ot1wi3xi 57 6 recognizable recognizable JJ cord-016990-ot1wi3xi 57 7 tissue tissue NN cord-016990-ot1wi3xi 57 8 reaction reaction NN cord-016990-ot1wi3xi 57 9 patterns pattern NNS cord-016990-ot1wi3xi 57 10 including include VBG cord-016990-ot1wi3xi 57 11 necrotizing necrotize VBG cord-016990-ot1wi3xi 57 12 tracheobronchitis tracheobronchitis NN cord-016990-ot1wi3xi 57 13 , , , cord-016990-ot1wi3xi 57 14 bronchiolitis bronchiolitis NN cord-016990-ot1wi3xi 57 15 , , , cord-016990-ot1wi3xi 57 16 and and CC cord-016990-ot1wi3xi 57 17 interstitial interstitial JJ cord-016990-ot1wi3xi 57 18 pneumonia pneumonia NN cord-016990-ot1wi3xi 57 19 . . . cord-016990-ot1wi3xi 58 1 A a DT cord-016990-ot1wi3xi 58 2 summary summary NN cord-016990-ot1wi3xi 58 3 of of IN cord-016990-ot1wi3xi 58 4 the the DT cord-016990-ot1wi3xi 58 5 key key JJ cord-016990-ot1wi3xi 58 6 diagnostic diagnostic JJ cord-016990-ot1wi3xi 58 7 histopathologic histopathologic NNP cord-016990-ot1wi3xi 58 8 and and CC cord-016990-ot1wi3xi 58 9 ultrastructural ultrastructural JJ cord-016990-ot1wi3xi 58 10 features feature VBZ cord-016990-ot1wi3xi 58 11 for for IN cord-016990-ot1wi3xi 58 12 the the DT cord-016990-ot1wi3xi 58 13 most most RBS cord-016990-ot1wi3xi 58 14 common common JJ cord-016990-ot1wi3xi 58 15 viral viral JJ cord-016990-ot1wi3xi 58 16 pathogens pathogen NNS cord-016990-ot1wi3xi 58 17 that that WDT cord-016990-ot1wi3xi 58 18 cause cause VBP cord-016990-ot1wi3xi 58 19 a a DT cord-016990-ot1wi3xi 58 20 majority majority NN cord-016990-ot1wi3xi 58 21 of of IN cord-016990-ot1wi3xi 58 22 pulmonary pulmonary JJ cord-016990-ot1wi3xi 58 23 infections infection NNS cord-016990-ot1wi3xi 58 24 is be VBZ cord-016990-ot1wi3xi 58 25 provided provide VBN cord-016990-ot1wi3xi 58 26 in in IN cord-016990-ot1wi3xi 58 27 Tables table NNS cord-016990-ot1wi3xi 58 28 11.2 11.2 CD cord-016990-ot1wi3xi 58 29 and and CC cord-016990-ot1wi3xi 58 30 11.3 11.3 CD cord-016990-ot1wi3xi 58 31 . . . cord-016990-ot1wi3xi 59 1 Yes yes UH cord-016990-ot1wi3xi 59 2 ( ( -LRB- cord-016990-ot1wi3xi 59 3 cytoplasmic cytoplasmic JJ cord-016990-ot1wi3xi 59 4 ; ; : cord-016990-ot1wi3xi 59 5 ill ill RB cord-016990-ot1wi3xi 59 6 - - HYPH cord-016990-ot1wi3xi 59 7 defined define VBN cord-016990-ot1wi3xi 59 8 ) ) -RRB- cord-016990-ot1wi3xi 60 1 Yes yes UH cord-016990-ot1wi3xi 61 1 ( ( -LRB- cord-016990-ot1wi3xi 61 2 nuclear nuclear JJ cord-016990-ot1wi3xi 61 3 and and CC cord-016990-ot1wi3xi 61 4 cytoplasmic cytoplasmic JJ cord-016990-ot1wi3xi 61 5 ) ) -RRB- cord-016990-ot1wi3xi 62 1 Pulmonary pulmonary JJ cord-016990-ot1wi3xi 62 2 tissue tissue NN cord-016990-ot1wi3xi 62 3 reaction reaction NN cord-016990-ot1wi3xi 63 1 Necrotizing necrotize VBG cord-016990-ot1wi3xi 63 2 bronchiolitis bronchiolitis NN cord-016990-ot1wi3xi 63 3 ; ; : cord-016990-ot1wi3xi 63 4 smudge smudge NN cord-016990-ot1wi3xi 63 5 cells cell NNS cord-016990-ot1wi3xi 64 1 ; ; : cord-016990-ot1wi3xi 64 2 DAD DAD NNP cord-016990-ot1wi3xi 64 3 Severe severe JJ cord-016990-ot1wi3xi 64 4 edema edema NN cord-016990-ot1wi3xi 64 5 , , , cord-016990-ot1wi3xi 64 6 early early JJ cord-016990-ot1wi3xi 64 7 DAD DAD NNP cord-016990-ot1wi3xi 64 8 Interstitial Interstitial NNP cord-016990-ot1wi3xi 64 9 pneumonia pneumonia NN cord-016990-ot1wi3xi 64 10 ; ; : cord-016990-ot1wi3xi 64 11 DAD dad NN cord-016990-ot1wi3xi 64 12 ; ; : cord-016990-ot1wi3xi 64 13 occasional occasional JJ cord-016990-ot1wi3xi 64 14 multinucleation multinucleation NN cord-016990-ot1wi3xi 64 15 Interstitial interstitial JJ cord-016990-ot1wi3xi 64 16 pneumonia pneumonia NN cord-016990-ot1wi3xi 64 17 ; ; : cord-016990-ot1wi3xi 64 18 DAD DAD NNP cord-016990-ot1wi3xi 64 19 ; ; : cord-016990-ot1wi3xi 64 20 cytomegaly cytomegaly NNP cord-016990-ot1wi3xi 64 21 DAD DAD NNP cord-016990-ot1wi3xi 64 22 ; ; : cord-016990-ot1wi3xi 64 23 necrosis necrosis NN cord-016990-ot1wi3xi 64 24 and and CC cord-016990-ot1wi3xi 64 25 rare rare JJ cord-016990-ot1wi3xi 64 26 multinucleation multinucleation NN cord-016990-ot1wi3xi 64 27 DAD DAD NNP cord-016990-ot1wi3xi 64 28 ; ; : cord-016990-ot1wi3xi 64 29 necrosis necrosis NN cord-016990-ot1wi3xi 64 30 and and CC cord-016990-ot1wi3xi 64 31 rare rare JJ cord-016990-ot1wi3xi 64 32 multinucleation multinucleation NN cord-016990-ot1wi3xi 64 33 DAD DAD NNP cord-016990-ot1wi3xi 64 34 ; ; : cord-016990-ot1wi3xi 64 35 necrotizing necrotize VBG cord-016990-ot1wi3xi 64 36 bronchiolitis bronchiolitis NN cord-016990-ot1wi3xi 64 37 Interstitial interstitial JJ cord-016990-ot1wi3xi 64 38 pneumonia pneumonia NN cord-016990-ot1wi3xi 64 39 with with IN cord-016990-ot1wi3xi 64 40 multi multi JJ cord-016990-ot1wi3xi 64 41 nucleation nucleation NN cord-016990-ot1wi3xi 64 42 DAD DAD NNP cord-016990-ot1wi3xi 64 43 DAD DAD NNP cord-016990-ot1wi3xi 64 44 ; ; : cord-016990-ot1wi3xi 64 45 interstitial interstitial JJ cord-016990-ot1wi3xi 64 46 pneumonia pneumonia NN cord-016990-ot1wi3xi 64 47 with with IN cord-016990-ot1wi3xi 64 48 occasional occasional JJ cord-016990-ot1wi3xi 64 49 multinucleation multinucleation NN cord-016990-ot1wi3xi 64 50 Necrotizing necrotize VBG cord-016990-ot1wi3xi 64 51 bronchiolitis bronchiolitis NN cord-016990-ot1wi3xi 64 52 , , , cord-016990-ot1wi3xi 64 53 interstitial interstitial JJ cord-016990-ot1wi3xi 64 54 pneumonia pneumonia NN cord-016990-ot1wi3xi 64 55 with with IN cord-016990-ot1wi3xi 64 56 occasional occasional JJ cord-016990-ot1wi3xi 64 57 multinucleation multinucleation NN cord-016990-ot1wi3xi 64 58 Recently recently RB cord-016990-ot1wi3xi 64 59 recognized recognize VBN cord-016990-ot1wi3xi 64 60 ; ; : cord-016990-ot1wi3xi 64 61 human human JJ cord-016990-ot1wi3xi 64 62 pathology pathology NN cord-016990-ot1wi3xi 64 63 not not RB cord-016990-ot1wi3xi 64 64 well well RB cord-016990-ot1wi3xi 64 65 described describe VBN cord-016990-ot1wi3xi 64 66 Interstitial interstitial JJ cord-016990-ot1wi3xi 64 67 pneumonia pneumonia NN cord-016990-ot1wi3xi 64 68 with with IN cord-016990-ot1wi3xi 64 69 multinucleation multinucleation NN cord-016990-ot1wi3xi 64 70 ; ; : cord-016990-ot1wi3xi 64 71 DAD DAD NNP cord-016990-ot1wi3xi 64 72 Only only RB cord-016990-ot1wi3xi 64 73 certain certain JJ cord-016990-ot1wi3xi 64 74 viruses virus NNS cord-016990-ot1wi3xi 64 75 can can MD cord-016990-ot1wi3xi 64 76 cause cause VB cord-016990-ot1wi3xi 64 77 cytopathic cytopathic JJ cord-016990-ot1wi3xi 64 78 changes change NNS cord-016990-ot1wi3xi 64 79 that that WDT cord-016990-ot1wi3xi 64 80 are be VBP cord-016990-ot1wi3xi 64 81 sufficiently sufficiently RB cord-016990-ot1wi3xi 64 82 distinct distinct JJ cord-016990-ot1wi3xi 64 83 to to TO cord-016990-ot1wi3xi 64 84 enable enable VB cord-016990-ot1wi3xi 64 85 the the DT cord-016990-ot1wi3xi 64 86 pathologist pathologist NN cord-016990-ot1wi3xi 64 87 to to TO cord-016990-ot1wi3xi 64 88 recognize recognize VB cord-016990-ot1wi3xi 64 89 a a DT cord-016990-ot1wi3xi 64 90 specific specific JJ cord-016990-ot1wi3xi 64 91 diagnosis diagnosis NN cord-016990-ot1wi3xi 64 92 on on IN cord-016990-ot1wi3xi 64 93 routine routine JJ cord-016990-ot1wi3xi 64 94 histologic histologic JJ cord-016990-ot1wi3xi 64 95 examination examination NN cord-016990-ot1wi3xi 64 96 of of IN cord-016990-ot1wi3xi 64 97 lung lung NN cord-016990-ot1wi3xi 64 98 specimens specimen NNS cord-016990-ot1wi3xi 64 99 . . . cord-016990-ot1wi3xi 65 1 With with IN cord-016990-ot1wi3xi 65 2 the the DT cord-016990-ot1wi3xi 65 3 availability availability NN cord-016990-ot1wi3xi 65 4 of of IN cord-016990-ot1wi3xi 65 5 special special JJ cord-016990-ot1wi3xi 65 6 FIGURE figure NN cord-016990-ot1wi3xi 65 7 11 11 CD cord-016990-ot1wi3xi 65 8 .1 .1 NNS cord-016990-ot1wi3xi 65 9 . . . cord-016990-ot1wi3xi 66 1 Negative negative JJ cord-016990-ot1wi3xi 66 2 stain stain NN cord-016990-ot1wi3xi 66 3 electron electron NN cord-016990-ot1wi3xi 66 4 microscopic microscopic JJ cord-016990-ot1wi3xi 66 5 images image NNS cord-016990-ot1wi3xi 66 6 of of IN cord-016990-ot1wi3xi 66 7 different different JJ cord-016990-ot1wi3xi 66 8 viruses virus NNS cord-016990-ot1wi3xi 66 9 that that WDT cord-016990-ot1wi3xi 66 10 can can MD cord-016990-ot1wi3xi 66 11 cause cause VB cord-016990-ot1wi3xi 66 12 pulmonary pulmonary JJ cord-016990-ot1wi3xi 66 13 infections infection NNS cord-016990-ot1wi3xi 66 14 . . . cord-016990-ot1wi3xi 67 1 A. A. NNP cord-016990-ot1wi3xi 67 2 Adenovirus Adenovirus NNP cord-016990-ot1wi3xi 67 3 . . . cord-016990-ot1wi3xi 68 1 Adenoviruses adenovirus NNS cord-016990-ot1wi3xi 68 2 are be VBP cord-016990-ot1wi3xi 68 3 protein protein NN cord-016990-ot1wi3xi 68 4 - - HYPH cord-016990-ot1wi3xi 68 5 shelled shell VBN cord-016990-ot1wi3xi 68 6 icosahedral icosahedral JJ cord-016990-ot1wi3xi 68 7 - - HYPH cord-016990-ot1wi3xi 68 8 shaped shape VBN cord-016990-ot1wi3xi 68 9 nonenveloped nonenveloped JJ cord-016990-ot1wi3xi 68 10 viruses virus NNS cord-016990-ot1wi3xi 68 11 that that WDT cord-016990-ot1wi3xi 68 12 measure measure VBP cord-016990-ot1wi3xi 68 13 approximately approximately RB cord-016990-ot1wi3xi 68 14 70 70 CD cord-016990-ot1wi3xi 68 15 to to TO cord-016990-ot1wi3xi 68 16 90 90 CD cord-016990-ot1wi3xi 68 17 nm nm NN cord-016990-ot1wi3xi 68 18 in in IN cord-016990-ot1wi3xi 68 19 diameter diameter NN cord-016990-ot1wi3xi 68 20 . . . cord-016990-ot1wi3xi 69 1 Two two CD cord-016990-ot1wi3xi 69 2 of of IN cord-016990-ot1wi3xi 69 3 the the DT cord-016990-ot1wi3xi 69 4 viruses virus NNS cord-016990-ot1wi3xi 69 5 are be VBP cord-016990-ot1wi3xi 69 6 stain stain NN cord-016990-ot1wi3xi 69 7 penetrated penetrate VBD cord-016990-ot1wi3xi 69 8 revealing reveal VBG cord-016990-ot1wi3xi 69 9 the the DT cord-016990-ot1wi3xi 69 10 DNA dna NN cord-016990-ot1wi3xi 69 11 - - HYPH cord-016990-ot1wi3xi 69 12 containing contain VBG cord-016990-ot1wi3xi 69 13 nucleoprotein nucleoprotein NNP cord-016990-ot1wi3xi 69 14 . . . cord-016990-ot1wi3xi 70 1 B. B. NNP cord-016990-ot1wi3xi 70 2 Sin Sin NNP cord-016990-ot1wi3xi 70 3 Nombre Nombre NNP cord-016990-ot1wi3xi 70 4 virus virus NN cord-016990-ot1wi3xi 70 5 . . . cord-016990-ot1wi3xi 71 1 Sin sin NN cord-016990-ot1wi3xi 71 2 Nombre Nombre NNP cord-016990-ot1wi3xi 71 3 virus virus NN cord-016990-ot1wi3xi 71 4 , , , cord-016990-ot1wi3xi 71 5 the the DT cord-016990-ot1wi3xi 71 6 causative causative JJ cord-016990-ot1wi3xi 71 7 agent agent NN cord-016990-ot1wi3xi 71 8 of of IN cord-016990-ot1wi3xi 71 9 hantavirus hantavirus NNP cord-016990-ot1wi3xi 71 10 pulmonary pulmonary JJ cord-016990-ot1wi3xi 71 11 syndrome syndrome NN cord-016990-ot1wi3xi 71 12 , , , cord-016990-ot1wi3xi 71 13 belongs belong VBZ cord-016990-ot1wi3xi 71 14 to to IN cord-016990-ot1wi3xi 71 15 the the DT cord-016990-ot1wi3xi 71 16 genus genus NN cord-016990-ot1wi3xi 71 17 hantavirus hantavirus NN cord-016990-ot1wi3xi 71 18 in in IN cord-016990-ot1wi3xi 71 19 the the DT cord-016990-ot1wi3xi 71 20 family family NN cord-016990-ot1wi3xi 71 21 Bunyaviridae Bunyaviridae NNP cord-016990-ot1wi3xi 71 22 . . . cord-016990-ot1wi3xi 72 1 The the DT cord-016990-ot1wi3xi 72 2 envelopes envelope NNS cord-016990-ot1wi3xi 72 3 of of IN cord-016990-ot1wi3xi 72 4 hantaviruses hantaviruse NNS cord-016990-ot1wi3xi 72 5 are be VBP cord-016990-ot1wi3xi 72 6 checkerboard checkerboard VBN cord-016990-ot1wi3xi 72 7 in in IN cord-016990-ot1wi3xi 72 8 appearance appearance NN cord-016990-ot1wi3xi 72 9 , , , cord-016990-ot1wi3xi 72 10 and and CC cord-016990-ot1wi3xi 72 11 particles particle NNS cord-016990-ot1wi3xi 72 12 measure measure VBP cord-016990-ot1wi3xi 72 13 90 90 CD cord-016990-ot1wi3xi 72 14 to to TO cord-016990-ot1wi3xi 72 15 150 150 CD cord-016990-ot1wi3xi 72 16 nm nm NN cord-016990-ot1wi3xi 72 17 in in IN cord-016990-ot1wi3xi 72 18 diameter diameter NN cord-016990-ot1wi3xi 72 19 . . . cord-016990-ot1wi3xi 73 1 C. C. NNP cord-016990-ot1wi3xi 73 2 Herpes Herpes NNP cord-016990-ot1wi3xi 73 3 simplex simplex NN cord-016990-ot1wi3xi 73 4 virus virus NN cord-016990-ot1wi3xi 73 5 . . . cord-016990-ot1wi3xi 74 1 The the DT cord-016990-ot1wi3xi 74 2 stain stain NN cord-016990-ot1wi3xi 74 3 has have VBZ cord-016990-ot1wi3xi 74 4 penetrated penetrate VBN cord-016990-ot1wi3xi 74 5 the the DT cord-016990-ot1wi3xi 74 6 envelope envelope NN cord-016990-ot1wi3xi 74 7 of of IN cord-016990-ot1wi3xi 74 8 several several JJ cord-016990-ot1wi3xi 74 9 of of IN cord-016990-ot1wi3xi 74 10 these these DT cord-016990-ot1wi3xi 74 11 herpesvirus herpesvirus NN cord-016990-ot1wi3xi 74 12 particles particle NNS cord-016990-ot1wi3xi 74 13 , , , cord-016990-ot1wi3xi 74 14 delineating delineate VBG cord-016990-ot1wi3xi 74 15 the the DT cord-016990-ot1wi3xi 74 16 icosahedral icosahedral JJ cord-016990-ot1wi3xi 74 17 - - HYPH cord-016990-ot1wi3xi 74 18 shaped shape VBN cord-016990-ot1wi3xi 74 19 nucleocapsids nucleocapsid NNS cord-016990-ot1wi3xi 74 20 , , , cord-016990-ot1wi3xi 74 21 which which WDT cord-016990-ot1wi3xi 74 22 measure measure VBP cord-016990-ot1wi3xi 74 23 90 90 CD cord-016990-ot1wi3xi 74 24 to to TO cord-016990-ot1wi3xi 74 25 100 100 CD cord-016990-ot1wi3xi 74 26 nm nm NN cord-016990-ot1wi3xi 74 27 in in IN cord-016990-ot1wi3xi 74 28 diameter diameter NN cord-016990-ot1wi3xi 74 29 . . . cord-016990-ot1wi3xi 75 1 D. D. NNP cord-016990-ot1wi3xi 75 2 Cytomegalovirus Cytomegalovirus NNP cord-016990-ot1wi3xi 75 3 . . . cord-016990-ot1wi3xi 76 1 Another another DT cord-016990-ot1wi3xi 76 2 herpesvirus herpesvirus NN cord-016990-ot1wi3xi 76 3 ; ; : cord-016990-ot1wi3xi 76 4 one one CD cord-016990-ot1wi3xi 76 5 virus virus NN cord-016990-ot1wi3xi 76 6 particle particle NN cord-016990-ot1wi3xi 76 7 ( ( -LRB- cord-016990-ot1wi3xi 76 8 left left NN cord-016990-ot1wi3xi 76 9 ) ) -RRB- cord-016990-ot1wi3xi 76 10 is be VBZ cord-016990-ot1wi3xi 76 11 intact intact JJ cord-016990-ot1wi3xi 76 12 while while IN cord-016990-ot1wi3xi 76 13 two two CD cord-016990-ot1wi3xi 76 14 nearby nearby JJ cord-016990-ot1wi3xi 76 15 particles particle NNS cord-016990-ot1wi3xi 76 16 are be VBP cord-016990-ot1wi3xi 76 17 stainpenetrated stainpenetrate VBN cord-016990-ot1wi3xi 76 18 and and CC cord-016990-ot1wi3xi 76 19 show show VB cord-016990-ot1wi3xi 76 20 the the DT cord-016990-ot1wi3xi 76 21 viral viral JJ cord-016990-ot1wi3xi 76 22 nucleocapsids nucleocapsid NNS cord-016990-ot1wi3xi 76 23 . . . cord-016990-ot1wi3xi 77 1 The the DT cord-016990-ot1wi3xi 77 2 nucleocapsid nucleocapsid NN cord-016990-ot1wi3xi 77 3 of of IN cord-016990-ot1wi3xi 77 4 the the DT cord-016990-ot1wi3xi 77 5 upper upper JJ cord-016990-ot1wi3xi 77 6 right right JJ cord-016990-ot1wi3xi 77 7 particle particle NN cord-016990-ot1wi3xi 77 8 shows show VBZ cord-016990-ot1wi3xi 77 9 a a DT cord-016990-ot1wi3xi 77 10 central central JJ cord-016990-ot1wi3xi 77 11 core core NN cord-016990-ot1wi3xi 77 12 that that WDT cord-016990-ot1wi3xi 77 13 harbors harbor VBZ cord-016990-ot1wi3xi 77 14 the the DT cord-016990-ot1wi3xi 77 15 DNA dna NN cord-016990-ot1wi3xi 77 16 of of IN cord-016990-ot1wi3xi 77 17 the the DT cord-016990-ot1wi3xi 77 18 virus virus NN cord-016990-ot1wi3xi 77 19 . . . cord-016990-ot1wi3xi 78 1 E. E. NNP cord-016990-ot1wi3xi 78 2 Influenza Influenza NNP cord-016990-ot1wi3xi 78 3 virus virus NN cord-016990-ot1wi3xi 78 4 . . . cord-016990-ot1wi3xi 79 1 Influenzaviruses influenzaviruse NNS cord-016990-ot1wi3xi 79 2 belong belong VBP cord-016990-ot1wi3xi 79 3 to to IN cord-016990-ot1wi3xi 79 4 the the DT cord-016990-ot1wi3xi 79 5 family family NN cord-016990-ot1wi3xi 79 6 Orthomyxoviridae Orthomyxoviridae NNP cord-016990-ot1wi3xi 79 7 ; ; , cord-016990-ot1wi3xi 79 8 viral viral JJ cord-016990-ot1wi3xi 79 9 particles particle NNS cord-016990-ot1wi3xi 79 10 are be VBP cord-016990-ot1wi3xi 79 11 pleomorphic pleomorphic JJ cord-016990-ot1wi3xi 79 12 S.R. S.R. NNP cord-016990-ot1wi3xi 79 13 Zaki Zaki NNP cord-016990-ot1wi3xi 79 14 and and CC cord-016990-ot1wi3xi 79 15 CD CD NNP cord-016990-ot1wi3xi 79 16 . . . cord-016990-ot1wi3xi 80 1 Paddock paddock NN cord-016990-ot1wi3xi 80 2 diagnostic diagnostic JJ cord-016990-ot1wi3xi 80 3 techniques technique NNS cord-016990-ot1wi3xi 80 4 , , , cord-016990-ot1wi3xi 80 5 such such JJ cord-016990-ot1wi3xi 80 6 as as IN cord-016990-ot1wi3xi 80 7 immunohistochemistry immunohistochemistry NN cord-016990-ot1wi3xi 80 8 ( ( -LRB- cord-016990-ot1wi3xi 80 9 IHC IHC NNP cord-016990-ot1wi3xi 80 10 ) ) -RRB- cord-016990-ot1wi3xi 80 11 and and CC cord-016990-ot1wi3xi 80 12 in in IN cord-016990-ot1wi3xi 80 13 - - HYPH cord-016990-ot1wi3xi 80 14 situ situ NN cord-016990-ot1wi3xi 80 15 hybridization hybridization NN cord-016990-ot1wi3xi 80 16 ( ( -LRB- cord-016990-ot1wi3xi 80 17 ISH ISH NNP cord-016990-ot1wi3xi 80 18 ) ) -RRB- cord-016990-ot1wi3xi 80 19 , , , cord-016990-ot1wi3xi 80 20 many many JJ cord-016990-ot1wi3xi 80 21 viruses virus NNS cord-016990-ot1wi3xi 80 22 can can MD cord-016990-ot1wi3xi 80 23 be be VB cord-016990-ot1wi3xi 80 24 detected detect VBN cord-016990-ot1wi3xi 80 25 in in IN cord-016990-ot1wi3xi 80 26 formalin formalin NN cord-016990-ot1wi3xi 80 27 - - HYPH cord-016990-ot1wi3xi 80 28 fixed fix VBN cord-016990-ot1wi3xi 80 29 , , , cord-016990-ot1wi3xi 80 30 paraffin paraffin NN cord-016990-ot1wi3xi 80 31 - - HYPH cord-016990-ot1wi3xi 80 32 embedded embed VBN cord-016990-ot1wi3xi 80 33 tissue tissue NN cord-016990-ot1wi3xi 80 34 samples sample NNS cord-016990-ot1wi3xi 80 35 even even RB cord-016990-ot1wi3xi 80 36 if if IN cord-016990-ot1wi3xi 80 37 specific specific JJ cord-016990-ot1wi3xi 80 38 viral viral JJ cord-016990-ot1wi3xi 80 39 inclusions inclusion NNS cord-016990-ot1wi3xi 80 40 can can MD cord-016990-ot1wi3xi 80 41 not not RB cord-016990-ot1wi3xi 80 42 be be VB cord-016990-ot1wi3xi 80 43 found find VBN cord-016990-ot1wi3xi 80 44 in in IN cord-016990-ot1wi3xi 80 45 histologic histologic JJ cord-016990-ot1wi3xi 80 46 examination examination NN cord-016990-ot1wi3xi 80 47 of of IN cord-016990-ot1wi3xi 80 48 tissue tissue NN cord-016990-ot1wi3xi 80 49 sections section NNS cord-016990-ot1wi3xi 80 50 . . . cord-016990-ot1wi3xi 81 1 Among among IN cord-016990-ot1wi3xi 81 2 the the DT cord-016990-ot1wi3xi 81 3 techniques technique NNS cord-016990-ot1wi3xi 81 4 , , , cord-016990-ot1wi3xi 81 5 IHC IHC NNP cord-016990-ot1wi3xi 81 6 utilizing utilize VBG cord-016990-ot1wi3xi 81 7 specific specific JJ cord-016990-ot1wi3xi 81 8 antibodies antibody NNS cord-016990-ot1wi3xi 81 9 can can MD cord-016990-ot1wi3xi 81 10 be be VB cord-016990-ot1wi3xi 81 11 routinely routinely RB cord-016990-ot1wi3xi 81 12 performed perform VBN cord-016990-ot1wi3xi 81 13 on on IN cord-016990-ot1wi3xi 81 14 formalin formalin NN cord-016990-ot1wi3xi 81 15 - - HYPH cord-016990-ot1wi3xi 81 16 fixed fix VBN cord-016990-ot1wi3xi 81 17 tissue tissue NN cord-016990-ot1wi3xi 81 18 and and CC cord-016990-ot1wi3xi 81 19 can can MD cord-016990-ot1wi3xi 81 20 enhance enhance VB cord-016990-ot1wi3xi 81 21 the the DT cord-016990-ot1wi3xi 81 22 pathologist pathologist NN cord-016990-ot1wi3xi 81 23 's 's POS cord-016990-ot1wi3xi 81 24 accuracy accuracy NN cord-016990-ot1wi3xi 81 25 in in IN cord-016990-ot1wi3xi 81 26 identifying identify VBG cord-016990-ot1wi3xi 81 27 organisms organism NNS cord-016990-ot1wi3xi 81 28 in in IN cord-016990-ot1wi3xi 81 29 tissue tissue NN cord-016990-ot1wi3xi 81 30 specimens specimen NNS cord-016990-ot1wi3xi 81 31 . . . cord-016990-ot1wi3xi 82 1 In in IN cord-016990-ot1wi3xi 82 2 addition addition NN cord-016990-ot1wi3xi 82 3 to to IN cord-016990-ot1wi3xi 82 4 histologic histologic JJ cord-016990-ot1wi3xi 82 5 pattern pattern NN cord-016990-ot1wi3xi 82 6 recognition recognition NN cord-016990-ot1wi3xi 82 7 , , , cord-016990-ot1wi3xi 82 8 IHC IHC NNP cord-016990-ot1wi3xi 82 9 , , , cord-016990-ot1wi3xi 82 10 and and CC cord-016990-ot1wi3xi 82 11 ISH ish NN cord-016990-ot1wi3xi 82 12 in in IN cord-016990-ot1wi3xi 82 13 tissue tissue NN cord-016990-ot1wi3xi 82 14 , , , cord-016990-ot1wi3xi 82 15 several several JJ cord-016990-ot1wi3xi 82 16 other other JJ cord-016990-ot1wi3xi 82 17 diagnostic diagnostic JJ cord-016990-ot1wi3xi 82 18 tests test NNS cord-016990-ot1wi3xi 82 19 are be VBP cord-016990-ot1wi3xi 82 20 available available JJ cord-016990-ot1wi3xi 82 21 to to TO cord-016990-ot1wi3xi 82 22 aid aid VB cord-016990-ot1wi3xi 82 23 the the DT cord-016990-ot1wi3xi 82 24 pathologist pathologist NN cord-016990-ot1wi3xi 82 25 . . . cord-016990-ot1wi3xi 83 1 Cell cell NN cord-016990-ot1wi3xi 83 2 culture culture NN cord-016990-ot1wi3xi 83 3 techniques technique NNS cord-016990-ot1wi3xi 83 4 , , , cord-016990-ot1wi3xi 83 5 serology serology NN cord-016990-ot1wi3xi 83 6 , , , cord-016990-ot1wi3xi 83 7 polymerase polymerase NN cord-016990-ot1wi3xi 83 8 chain chain NN cord-016990-ot1wi3xi 83 9 reaction reaction NN cord-016990-ot1wi3xi 83 10 ( ( -LRB- cord-016990-ot1wi3xi 83 11 PCR PCR NNP cord-016990-ot1wi3xi 83 12 ) ) -RRB- cord-016990-ot1wi3xi 83 13 , , , cord-016990-ot1wi3xi 83 14 and and CC cord-016990-ot1wi3xi 83 15 electron electron NN cord-016990-ot1wi3xi 83 16 microscopy microscopy NN cord-016990-ot1wi3xi 83 17 ( ( -LRB- cord-016990-ot1wi3xi 83 18 EM EM NNP cord-016990-ot1wi3xi 83 19 ) ) -RRB- cord-016990-ot1wi3xi 84 1 all all DT cord-016990-ot1wi3xi 84 2 play play VBP cord-016990-ot1wi3xi 84 3 vital vital JJ cord-016990-ot1wi3xi 84 4 roles role NNS cord-016990-ot1wi3xi 84 5 in in IN cord-016990-ot1wi3xi 84 6 the the DT cord-016990-ot1wi3xi 84 7 diagnosis diagnosis NN cord-016990-ot1wi3xi 84 8 of of IN cord-016990-ot1wi3xi 84 9 these these DT cord-016990-ot1wi3xi 84 10 infections infection NNS cord-016990-ot1wi3xi 84 11 . . . cord-016990-ot1wi3xi 85 1 While while IN cord-016990-ot1wi3xi 85 2 histologic histologic JJ cord-016990-ot1wi3xi 85 3 techniques technique NNS cord-016990-ot1wi3xi 85 4 can can MD cord-016990-ot1wi3xi 85 5 be be VB cord-016990-ot1wi3xi 85 6 an an DT cord-016990-ot1wi3xi 85 7 excellent excellent JJ cord-016990-ot1wi3xi 85 8 means mean NNS cord-016990-ot1wi3xi 85 9 of of IN cord-016990-ot1wi3xi 85 10 demonstrating demonstrate VBG cord-016990-ot1wi3xi 85 11 organisms organism NNS cord-016990-ot1wi3xi 85 12 , , , cord-016990-ot1wi3xi 85 13 tissue tissue NN cord-016990-ot1wi3xi 85 14 culture culture NN cord-016990-ot1wi3xi 85 15 isolation isolation NN cord-016990-ot1wi3xi 85 16 remains remain VBZ cord-016990-ot1wi3xi 85 17 essential essential JJ cord-016990-ot1wi3xi 85 18 for for IN cord-016990-ot1wi3xi 85 19 definitive definitive JJ cord-016990-ot1wi3xi 85 20 identification identification NN cord-016990-ot1wi3xi 85 21 of of IN cord-016990-ot1wi3xi 85 22 the the DT cord-016990-ot1wi3xi 85 23 virus virus NN cord-016990-ot1wi3xi 85 24 . . . cord-016990-ot1wi3xi 86 1 When when WRB cord-016990-ot1wi3xi 86 2 a a DT cord-016990-ot1wi3xi 86 3 viral viral JJ cord-016990-ot1wi3xi 86 4 pneumonia pneumonia NN cord-016990-ot1wi3xi 86 5 is be VBZ cord-016990-ot1wi3xi 86 6 suspected suspect VBN cord-016990-ot1wi3xi 86 7 , , , cord-016990-ot1wi3xi 86 8 samples sample NNS cord-016990-ot1wi3xi 86 9 of of IN cord-016990-ot1wi3xi 86 10 lung lung NN cord-016990-ot1wi3xi 86 11 tissues tissue NNS cord-016990-ot1wi3xi 86 12 should should MD cord-016990-ot1wi3xi 86 13 be be VB cord-016990-ot1wi3xi 86 14 evaluated evaluate VBN cord-016990-ot1wi3xi 86 15 by by IN cord-016990-ot1wi3xi 86 16 cell cell NN cord-016990-ot1wi3xi 86 17 culture culture NN cord-016990-ot1wi3xi 86 18 , , , cord-016990-ot1wi3xi 86 19 which which WDT cord-016990-ot1wi3xi 86 20 has have VBZ cord-016990-ot1wi3xi 86 21 the the DT cord-016990-ot1wi3xi 86 22 advantage advantage NN cord-016990-ot1wi3xi 86 23 of of IN cord-016990-ot1wi3xi 86 24 being be VBG cord-016990-ot1wi3xi 86 25 a a DT cord-016990-ot1wi3xi 86 26 nonbiased nonbiased JJ cord-016990-ot1wi3xi 86 27 method method NN cord-016990-ot1wi3xi 86 28 for for IN cord-016990-ot1wi3xi 86 29 screening screening NN cord-016990-ot1wi3xi 86 30 purposes purpose NNS cord-016990-ot1wi3xi 86 31 that that WDT cord-016990-ot1wi3xi 86 32 does do VBZ cord-016990-ot1wi3xi 86 33 not not RB cord-016990-ot1wi3xi 86 34 rely rely VB cord-016990-ot1wi3xi 86 35 on on IN cord-016990-ot1wi3xi 86 36 the the DT cord-016990-ot1wi3xi 86 37 availability availability NN cord-016990-ot1wi3xi 86 38 of of IN cord-016990-ot1wi3xi 86 39 specific specific JJ cord-016990-ot1wi3xi 86 40 antibodies antibody NNS cord-016990-ot1wi3xi 86 41 or or CC cord-016990-ot1wi3xi 86 42 probes probe NNS cord-016990-ot1wi3xi 86 43 . . . cord-016990-ot1wi3xi 87 1 Electron electron NN cord-016990-ot1wi3xi 87 2 microscopy microscopy NN cord-016990-ot1wi3xi 87 3 offers offer VBZ cord-016990-ot1wi3xi 87 4 the the DT cord-016990-ot1wi3xi 87 5 same same JJ cord-016990-ot1wi3xi 87 6 utility utility NN cord-016990-ot1wi3xi 87 7 as as IN cord-016990-ot1wi3xi 87 8 a a DT cord-016990-ot1wi3xi 87 9 broad broad JJ cord-016990-ot1wi3xi 87 10 scope scope NN cord-016990-ot1wi3xi 87 11 diagnostic diagnostic JJ cord-016990-ot1wi3xi 87 12 tool tool NN cord-016990-ot1wi3xi 87 13 and and CC cord-016990-ot1wi3xi 87 14 has have VBZ cord-016990-ot1wi3xi 87 15 been be VBN cord-016990-ot1wi3xi 87 16 especially especially RB cord-016990-ot1wi3xi 87 17 critical critical JJ cord-016990-ot1wi3xi 87 18 in in IN cord-016990-ot1wi3xi 87 19 outbreaks outbreak NNS cord-016990-ot1wi3xi 87 20 of of IN cord-016990-ot1wi3xi 87 21 unknown unknown JJ cord-016990-ot1wi3xi 87 22 etiology etiology NN cord-016990-ot1wi3xi 87 23 . . . cord-016990-ot1wi3xi 88 1 It -PRON- PRP cord-016990-ot1wi3xi 88 2 played play VBD cord-016990-ot1wi3xi 88 3 a a DT cord-016990-ot1wi3xi 88 4 critical critical JJ cord-016990-ot1wi3xi 88 5 role role NN cord-016990-ot1wi3xi 88 6 during during IN cord-016990-ot1wi3xi 88 7 the the DT cord-016990-ot1wi3xi 88 8 Hendra Hendra NNP cord-016990-ot1wi3xi 88 9 and and CC cord-016990-ot1wi3xi 88 10 Nipah Nipah NNP cord-016990-ot1wi3xi 88 11 virus virus NN cord-016990-ot1wi3xi 88 12 outbreaks outbreak NNS cord-016990-ot1wi3xi 88 13 in in IN cord-016990-ot1wi3xi 88 14 1994 1994 CD cord-016990-ot1wi3xi 88 15 and and CC cord-016990-ot1wi3xi 88 16 1999 1999 CD cord-016990-ot1wi3xi 88 17 , , , cord-016990-ot1wi3xi 88 18 respectively respectively RB cord-016990-ot1wi3xi 88 19 , , , cord-016990-ot1wi3xi 88 20 and and CC cord-016990-ot1wi3xi 88 21 more more RBR cord-016990-ot1wi3xi 88 22 recently recently RB cord-016990-ot1wi3xi 88 23 , , , cord-016990-ot1wi3xi 88 24 in in IN cord-016990-ot1wi3xi 88 25 the the DT cord-016990-ot1wi3xi 88 26 early early JJ cord-016990-ot1wi3xi 88 27 recognition recognition NN cord-016990-ot1wi3xi 88 28 of of IN cord-016990-ot1wi3xi 88 29 a a DT cord-016990-ot1wi3xi 88 30 novel novel JJ cord-016990-ot1wi3xi 88 31 coronavirus coronavirus NN cord-016990-ot1wi3xi 88 32 associated associate VBN cord-016990-ot1wi3xi 88 33 with with IN cord-016990-ot1wi3xi 88 34 SARS SARS NNP cord-016990-ot1wi3xi 88 35 in in IN cord-016990-ot1wi3xi 88 36 2003 2003 CD cord-016990-ot1wi3xi 88 37 and and CC cord-016990-ot1wi3xi 88 38 in in IN cord-016990-ot1wi3xi 88 39 the the DT cord-016990-ot1wi3xi 88 40 diagnosis diagnosis NN cord-016990-ot1wi3xi 88 41 of of IN cord-016990-ot1wi3xi 88 42 emerging emerge VBG cord-016990-ot1wi3xi 88 43 transplant transplant NN cord-016990-ot1wi3xi 88 44 - - HYPH cord-016990-ot1wi3xi 88 45 associated associate VBN cord-016990-ot1wi3xi 88 46 infections infection NNS cord-016990-ot1wi3xi 88 47 . . . cord-016990-ot1wi3xi 89 1 13.22.29 13.22.29 LS cord-016990-ot1wi3xi 89 2 - - SYM cord-016990-ot1wi3xi 89 3 33 33 CD cord-016990-ot1wi3xi 90 1 The the DT cord-016990-ot1wi3xi 90 2 advantage advantage NN cord-016990-ot1wi3xi 90 3 of of IN cord-016990-ot1wi3xi 90 4 this this DT cord-016990-ot1wi3xi 90 5 approach approach NN cord-016990-ot1wi3xi 90 6 is be VBZ cord-016990-ot1wi3xi 90 7 that that IN cord-016990-ot1wi3xi 90 8 viral viral JJ cord-016990-ot1wi3xi 90 9 particles particle NNS cord-016990-ot1wi3xi 90 10 may may MD cord-016990-ot1wi3xi 90 11 be be VB cord-016990-ot1wi3xi 90 12 demonstrated demonstrate VBN cord-016990-ot1wi3xi 90 13 by by IN cord-016990-ot1wi3xi 90 14 negative negative JJ cord-016990-ot1wi3xi 90 15 stain stain NN cord-016990-ot1wi3xi 90 16 or or CC cord-016990-ot1wi3xi 90 17 thin thin JJ cord-016990-ot1wi3xi 90 18 section section NN cord-016990-ot1wi3xi 90 19 EM em NN cord-016990-ot1wi3xi 90 20 , , , cord-016990-ot1wi3xi 90 21 either either CC cord-016990-ot1wi3xi 90 22 directly directly RB cord-016990-ot1wi3xi 90 23 in in IN cord-016990-ot1wi3xi 90 24 clinical clinical JJ cord-016990-ot1wi3xi 90 25 material material NN cord-016990-ot1wi3xi 90 26 or or CC cord-016990-ot1wi3xi 90 27 after after IN cord-016990-ot1wi3xi 90 28 amplification amplification NN cord-016990-ot1wi3xi 90 29 in in IN cord-016990-ot1wi3xi 90 30 cell cell NN cord-016990-ot1wi3xi 90 31 culture culture NN cord-016990-ot1wi3xi 90 32 . . . cord-016990-ot1wi3xi 91 1 Like like IN cord-016990-ot1wi3xi 91 2 culture culture NN cord-016990-ot1wi3xi 91 3 , , , cord-016990-ot1wi3xi 91 4 EM EM NNP cord-016990-ot1wi3xi 91 5 is be VBZ cord-016990-ot1wi3xi 91 6 not not RB cord-016990-ot1wi3xi 91 7 limited limit VBN cord-016990-ot1wi3xi 91 8 by by IN cord-016990-ot1wi3xi 91 9 narrow narrow JJ cord-016990-ot1wi3xi 91 10 specificity specificity NN cord-016990-ot1wi3xi 91 11 of of IN cord-016990-ot1wi3xi 91 12 reagents reagent NNS cord-016990-ot1wi3xi 91 13 or or CC cord-016990-ot1wi3xi 91 14 by by IN cord-016990-ot1wi3xi 91 15 prior prior JJ cord-016990-ot1wi3xi 91 16 clinical clinical JJ cord-016990-ot1wi3xi 91 17 bias bias NN cord-016990-ot1wi3xi 92 1 ( ( -LRB- cord-016990-ot1wi3xi 92 2 Fig Fig NNP cord-016990-ot1wi3xi 92 3 . . . cord-016990-ot1wi3xi 92 4 11 11 CD cord-016990-ot1wi3xi 92 5 .1 .1 CD cord-016990-ot1wi3xi 92 6 ) ) -RRB- cord-016990-ot1wi3xi 92 7 . . . cord-016990-ot1wi3xi 93 1 and and CC cord-016990-ot1wi3xi 93 2 can can MD cord-016990-ot1wi3xi 93 3 be be VB cord-016990-ot1wi3xi 93 4 filamentous filamentous JJ cord-016990-ot1wi3xi 93 5 or or CC cord-016990-ot1wi3xi 93 6 spherical spherical JJ cord-016990-ot1wi3xi 93 7 in in IN cord-016990-ot1wi3xi 93 8 shape shape NN cord-016990-ot1wi3xi 93 9 . . . cord-016990-ot1wi3xi 94 1 The the DT cord-016990-ot1wi3xi 94 2 evenly evenly RB cord-016990-ot1wi3xi 94 3 spaced space VBN cord-016990-ot1wi3xi 94 4 spikes spike NNS cord-016990-ot1wi3xi 94 5 cover cover VBP cord-016990-ot1wi3xi 94 6 the the DT cord-016990-ot1wi3xi 94 7 entire entire JJ cord-016990-ot1wi3xi 94 8 virus virus NN cord-016990-ot1wi3xi 94 9 surface surface NN cord-016990-ot1wi3xi 94 10 and and CC cord-016990-ot1wi3xi 94 11 contain contain VBP cord-016990-ot1wi3xi 94 12 both both CC cord-016990-ot1wi3xi 94 13 the the DT cord-016990-ot1wi3xi 94 14 hemagglutinin hemagglutinin NN cord-016990-ot1wi3xi 94 15 and and CC cord-016990-ot1wi3xi 94 16 neuraminidase neuraminidase NN cord-016990-ot1wi3xi 94 17 surface surface NN cord-016990-ot1wi3xi 94 18 glycoproteins glycoprotein NNS cord-016990-ot1wi3xi 94 19 . . . cord-016990-ot1wi3xi 95 1 F. F. NNP cord-016990-ot1wi3xi 95 2 Human Human NNP cord-016990-ot1wi3xi 95 3 metapneumovirus metapneumovirus NN cord-016990-ot1wi3xi 95 4 . . . cord-016990-ot1wi3xi 96 1 These these DT cord-016990-ot1wi3xi 96 2 paramyxoviruses paramyxovirus NNS cord-016990-ot1wi3xi 96 3 are be VBP cord-016990-ot1wi3xi 96 4 heterogeneous heterogeneous JJ cord-016990-ot1wi3xi 96 5 in in IN cord-016990-ot1wi3xi 96 6 size size NN cord-016990-ot1wi3xi 96 7 and and CC cord-016990-ot1wi3xi 96 8 shape shape NN cord-016990-ot1wi3xi 96 9 , , , cord-016990-ot1wi3xi 96 10 and and CC cord-016990-ot1wi3xi 96 11 range range NN cord-016990-ot1wi3xi 96 12 in in IN cord-016990-ot1wi3xi 96 13 size size NN cord-016990-ot1wi3xi 96 14 from from IN cord-016990-ot1wi3xi 96 15 150 150 CD cord-016990-ot1wi3xi 96 16 nm nm NN cord-016990-ot1wi3xi 96 17 to to IN cord-016990-ot1wi3xi 96 18 1 1 CD cord-016990-ot1wi3xi 96 19 J.lm j.lm CD cord-016990-ot1wi3xi 96 20 in in IN cord-016990-ot1wi3xi 96 21 diameter diameter NN cord-016990-ot1wi3xi 96 22 . . . cord-016990-ot1wi3xi 97 1 G. G. NNP cord-016990-ot1wi3xi 97 2 Parainfluenza Parainfluenza NNP cord-016990-ot1wi3xi 97 3 virus virus NN cord-016990-ot1wi3xi 97 4 . . . cord-016990-ot1wi3xi 98 1 Another another DT cord-016990-ot1wi3xi 98 2 paramyxovirus paramyxovirus NN cord-016990-ot1wi3xi 98 3 , , , cord-016990-ot1wi3xi 98 4 the the DT cord-016990-ot1wi3xi 98 5 viral viral JJ cord-016990-ot1wi3xi 98 6 nucleocapsid nucleocapsid NN cord-016990-ot1wi3xi 98 7 , , , cord-016990-ot1wi3xi 98 8 with with IN cord-016990-ot1wi3xi 98 9 its -PRON- PRP$ cord-016990-ot1wi3xi 98 10 typical typical JJ cord-016990-ot1wi3xi 98 11 herringbone herringbone NN cord-016990-ot1wi3xi 98 12 appearance appearance NN cord-016990-ot1wi3xi 98 13 , , , cord-016990-ot1wi3xi 98 14 can can MD cord-016990-ot1wi3xi 98 15 be be VB cord-016990-ot1wi3xi 98 16 seen see VBN cord-016990-ot1wi3xi 98 17 both both CC cord-016990-ot1wi3xi 98 18 within within IN cord-016990-ot1wi3xi 98 19 the the DT cord-016990-ot1wi3xi 98 20 stain stain NN cord-016990-ot1wi3xi 98 21 - - HYPH cord-016990-ot1wi3xi 98 22 penetrated penetrate VBN cord-016990-ot1wi3xi 98 23 particle particle NN cord-016990-ot1wi3xi 98 24 as as RB cord-016990-ot1wi3xi 98 25 well well RB cord-016990-ot1wi3xi 98 26 as as IN cord-016990-ot1wi3xi 98 27 partially partially RB cord-016990-ot1wi3xi 98 28 extruded extrude VBN cord-016990-ot1wi3xi 98 29 from from IN cord-016990-ot1wi3xi 98 30 the the DT cord-016990-ot1wi3xi 98 31 virion virion NN cord-016990-ot1wi3xi 98 32 . . . cord-016990-ot1wi3xi 99 1 An an DT cord-016990-ot1wi3xi 99 2 important important JJ cord-016990-ot1wi3xi 99 3 feature feature NN cord-016990-ot1wi3xi 99 4 that that WDT cord-016990-ot1wi3xi 99 5 can can MD cord-016990-ot1wi3xi 99 6 help help VB cord-016990-ot1wi3xi 99 7 distinguish distinguish VB cord-016990-ot1wi3xi 99 8 between between IN cord-016990-ot1wi3xi 99 9 Paramyxovirinae Paramyxovirinae NNP cord-016990-ot1wi3xi 99 10 ( ( -LRB- cord-016990-ot1wi3xi 99 11 parainfluenza parainfluenza NNP cord-016990-ot1wi3xi 99 12 and and CC cord-016990-ot1wi3xi 99 13 measles measles NNP cord-016990-ot1wi3xi 99 14 viruses virus NNS cord-016990-ot1wi3xi 99 15 ) ) -RRB- cord-016990-ot1wi3xi 99 16 and and CC cord-016990-ot1wi3xi 99 17 Pneumovirinae Pneumovirinae NNP cord-016990-ot1wi3xi 99 18 ( ( -LRB- cord-016990-ot1wi3xi 99 19 human human JJ cord-016990-ot1wi3xi 99 20 metapneumovirus metapneumovirus NN cord-016990-ot1wi3xi 99 21 and and CC cord-016990-ot1wi3xi 99 22 respiratory respiratory JJ cord-016990-ot1wi3xi 99 23 syncytial syncytial JJ cord-016990-ot1wi3xi 99 24 virus virus NN cord-016990-ot1wi3xi 99 25 ) ) -RRB- cord-016990-ot1wi3xi 99 26 is be VBZ cord-016990-ot1wi3xi 99 27 the the DT cord-016990-ot1wi3xi 99 28 diameter diameter NN cord-016990-ot1wi3xi 99 29 of of IN cord-016990-ot1wi3xi 99 30 the the DT cord-016990-ot1wi3xi 99 31 nucleocapsids nucleocapsid NNS cord-016990-ot1wi3xi 99 32 , , , cord-016990-ot1wi3xi 99 33 which which WDT cord-016990-ot1wi3xi 99 34 measure measure VBP cord-016990-ot1wi3xi 99 35 18 18 CD cord-016990-ot1wi3xi 99 36 nm nm NN cord-016990-ot1wi3xi 99 37 and and CC cord-016990-ot1wi3xi 99 38 14 14 CD cord-016990-ot1wi3xi 99 39 nm nm NN cord-016990-ot1wi3xi 99 40 , , , cord-016990-ot1wi3xi 99 41 respectively respectively RB cord-016990-ot1wi3xi 99 42 . . . cord-016990-ot1wi3xi 100 1 H. H. NNP cord-016990-ot1wi3xi 100 2 Severe severe JJ cord-016990-ot1wi3xi 100 3 acute acute JJ cord-016990-ot1wi3xi 100 4 respiratory respiratory JJ cord-016990-ot1wi3xi 100 5 syndrome syndrome NN cord-016990-ot1wi3xi 100 6 ( ( -LRB- cord-016990-ot1wi3xi 100 7 SARS SARS NNP cord-016990-ot1wi3xi 100 8 ) ) -RRB- cord-016990-ot1wi3xi 100 9 coronavirus coronavirus NN cord-016990-ot1wi3xi 100 10 . . . cord-016990-ot1wi3xi 101 1 These these DT cord-016990-ot1wi3xi 101 2 80-to 80-to CD cord-016990-ot1wi3xi 101 3 100-nm 100-nm CD cord-016990-ot1wi3xi 101 4 particles particle NNS cord-016990-ot1wi3xi 101 5 are be VBP cord-016990-ot1wi3xi 101 6 named name VBN cord-016990-ot1wi3xi 101 7 for for IN cord-016990-ot1wi3xi 101 8 the the DT cord-016990-ot1wi3xi 101 9 characteristic characteristic JJ cord-016990-ot1wi3xi 101 10 crown crown NN cord-016990-ot1wi3xi 101 11 - - HYPH cord-016990-ot1wi3xi 101 12 like like JJ cord-016990-ot1wi3xi 101 13 fringe fringe NN cord-016990-ot1wi3xi 101 14 on on IN cord-016990-ot1wi3xi 101 15 the the DT cord-016990-ot1wi3xi 101 16 surface surface NN cord-016990-ot1wi3xi 101 17 . . . cord-016990-ot1wi3xi 102 1 Scale scale NN cord-016990-ot1wi3xi 102 2 bars bar NNS cord-016990-ot1wi3xi 102 3 , , , cord-016990-ot1wi3xi 102 4 100 100 CD cord-016990-ot1wi3xi 102 5 nm nm NN cord-016990-ot1wi3xi 102 6 . . . cord-016990-ot1wi3xi 103 1 ( ( -LRB- cord-016990-ot1wi3xi 103 2 A A NNP cord-016990-ot1wi3xi 103 3 , , , cord-016990-ot1wi3xi 103 4 B b NN cord-016990-ot1wi3xi 103 5 , , , cord-016990-ot1wi3xi 103 6 D D NNP cord-016990-ot1wi3xi 103 7 , , , cord-016990-ot1wi3xi 103 8 F F NNP cord-016990-ot1wi3xi 103 9 , , , cord-016990-ot1wi3xi 103 10 H h NN cord-016990-ot1wi3xi 103 11 : : : cord-016990-ot1wi3xi 103 12 courtesy courtesy NN cord-016990-ot1wi3xi 103 13 of of IN cord-016990-ot1wi3xi 103 14 C. C. NNP cord-016990-ot1wi3xi 103 15 Humphrey Humphrey NNP cord-016990-ot1wi3xi 103 16 ; ; : cord-016990-ot1wi3xi 103 17 C C NNP cord-016990-ot1wi3xi 103 18 , , , cord-016990-ot1wi3xi 103 19 G g NN cord-016990-ot1wi3xi 103 20 : : : cord-016990-ot1wi3xi 103 21 courtesy courtesy NN cord-016990-ot1wi3xi 103 22 of of IN cord-016990-ot1wi3xi 103 23 E. E. NNP cord-016990-ot1wi3xi 103 24 Palmer Palmer NNP cord-016990-ot1wi3xi 103 25 ; ; : cord-016990-ot1wi3xi 103 26 E e NN cord-016990-ot1wi3xi 103 27 : : : cord-016990-ot1wi3xi 103 28 courtesy courtesy NN cord-016990-ot1wi3xi 103 29 of of IN cord-016990-ot1wi3xi 103 30 EA EA NNP cord-016990-ot1wi3xi 103 31 . . . cord-016990-ot1wi3xi 104 1 Murphy Murphy NNP cord-016990-ot1wi3xi 104 2 , , , cord-016990-ot1wi3xi 104 3 all all DT cord-016990-ot1wi3xi 104 4 at at IN cord-016990-ot1wi3xi 104 5 Centers Centers NNPS cord-016990-ot1wi3xi 104 6 for for IN cord-016990-ot1wi3xi 104 7 Disease Disease NNP cord-016990-ot1wi3xi 104 8 Control Control NNP cord-016990-ot1wi3xi 104 9 and and CC cord-016990-ot1wi3xi 104 10 Prevention Prevention NNP cord-016990-ot1wi3xi 104 11 , , , cord-016990-ot1wi3xi 104 12 Atlanta Atlanta NNP cord-016990-ot1wi3xi 104 13 , , , cord-016990-ot1wi3xi 104 14 GA GA NNP cord-016990-ot1wi3xi 104 15 . . . cord-016990-ot1wi3xi 104 16 ) ) -RRB- cord-016990-ot1wi3xi 105 1 Adenoviruses adenovirus NNS cord-016990-ot1wi3xi 105 2 were be VBD cord-016990-ot1wi3xi 105 3 first first RB cord-016990-ot1wi3xi 105 4 cultured cultured JJ cord-016990-ot1wi3xi 105 5 and and CC cord-016990-ot1wi3xi 105 6 identified identify VBN cord-016990-ot1wi3xi 105 7 during during IN cord-016990-ot1wi3xi 105 8 the the DT cord-016990-ot1wi3xi 105 9 early early JJ cord-016990-ot1wi3xi 105 10 1950s 1950 NNS cord-016990-ot1wi3xi 105 11 by by IN cord-016990-ot1wi3xi 105 12 investigators investigator NNS cord-016990-ot1wi3xi 105 13 searching search VBG cord-016990-ot1wi3xi 105 14 for for IN cord-016990-ot1wi3xi 105 15 etiologic etiologic JJ cord-016990-ot1wi3xi 105 16 agents agent NNS cord-016990-ot1wi3xi 105 17 of of IN cord-016990-ot1wi3xi 105 18 acute acute JJ cord-016990-ot1wi3xi 105 19 respiratory respiratory JJ cord-016990-ot1wi3xi 105 20 infections infection NNS cord-016990-ot1wi3xi 105 21 . . . cord-016990-ot1wi3xi 106 1 The the DT cord-016990-ot1wi3xi 106 2 initial initial JJ cord-016990-ot1wi3xi 106 3 adenovirus adenovirus NN cord-016990-ot1wi3xi 106 4 isolate isolate NN cord-016990-ot1wi3xi 106 5 was be VBD cord-016990-ot1wi3xi 106 6 made make VBN cord-016990-ot1wi3xi 106 7 serendipitously serendipitously RB cord-016990-ot1wi3xi 106 8 from from IN cord-016990-ot1wi3xi 106 9 adenoid adenoid JJ cord-016990-ot1wi3xi 106 10 tissues tissue NNS cord-016990-ot1wi3xi 106 11 obtained obtain VBN cord-016990-ot1wi3xi 106 12 from from IN cord-016990-ot1wi3xi 106 13 children child NNS cord-016990-ot1wi3xi 106 14 during during IN cord-016990-ot1wi3xi 106 15 efforts effort NNS cord-016990-ot1wi3xi 106 16 to to TO cord-016990-ot1wi3xi 106 17 establish establish VB cord-016990-ot1wi3xi 106 18 a a DT cord-016990-ot1wi3xi 106 19 primary primary JJ cord-016990-ot1wi3xi 106 20 human human JJ cord-016990-ot1wi3xi 106 21 adenoid adenoid NN cord-016990-ot1wi3xi 106 22 cell cell NN cord-016990-ot1wi3xi 106 23 line line NN cord-016990-ot1wi3xi 106 24 . . . cord-016990-ot1wi3xi 107 1 34 34 CD cord-016990-ot1wi3xi 108 1 A a DT cord-016990-ot1wi3xi 108 2 related related JJ cord-016990-ot1wi3xi 108 3 virus virus NN cord-016990-ot1wi3xi 108 4 was be VBD cord-016990-ot1wi3xi 108 5 identified identify VBN cord-016990-ot1wi3xi 108 6 the the DT cord-016990-ot1wi3xi 108 7 following following JJ cord-016990-ot1wi3xi 108 8 year year NN cord-016990-ot1wi3xi 108 9 by by IN cord-016990-ot1wi3xi 108 10 investigators investigator NNS cord-016990-ot1wi3xi 108 11 studying study VBG cord-016990-ot1wi3xi 108 12 respiratory respiratory JJ cord-016990-ot1wi3xi 108 13 disease disease NN cord-016990-ot1wi3xi 108 14 in in IN cord-016990-ot1wi3xi 108 15 military military NN cord-016990-ot1wi3xi 108 16 recruits?5 recruits?5 NNP cord-016990-ot1wi3xi 109 1 These these DT cord-016990-ot1wi3xi 109 2 agents agent NNS cord-016990-ot1wi3xi 109 3 were be VBD cord-016990-ot1wi3xi 109 4 subsequently subsequently RB cord-016990-ot1wi3xi 109 5 named name VBN cord-016990-ot1wi3xi 109 6 adenoviruses adenovirus NNS cord-016990-ot1wi3xi 109 7 after after IN cord-016990-ot1wi3xi 109 8 the the DT cord-016990-ot1wi3xi 109 9 original original JJ cord-016990-ot1wi3xi 109 10 source source NN cord-016990-ot1wi3xi 109 11 of of IN cord-016990-ot1wi3xi 109 12 tissue tissue NN cord-016990-ot1wi3xi 109 13 from from IN cord-016990-ot1wi3xi 109 14 which which WDT cord-016990-ot1wi3xi 109 15 the the DT cord-016990-ot1wi3xi 109 16 prototype prototype NN cord-016990-ot1wi3xi 109 17 strain strain NN cord-016990-ot1wi3xi 109 18 was be VBD cord-016990-ot1wi3xi 109 19 identified identify VBN cord-016990-ot1wi3xi 109 20 . . . cord-016990-ot1wi3xi 110 1 36 36 CD cord-016990-ot1wi3xi 110 2 Adenoviruses adenovirus NNS cord-016990-ot1wi3xi 110 3 are be VBP cord-016990-ot1wi3xi 110 4 non non RB cord-016990-ot1wi3xi 110 5 enveloped envelop VBN cord-016990-ot1wi3xi 110 6 viruses virus NNS cord-016990-ot1wi3xi 110 7 with with IN cord-016990-ot1wi3xi 110 8 a a DT cord-016990-ot1wi3xi 110 9 single single JJ cord-016990-ot1wi3xi 110 10 , , , cord-016990-ot1wi3xi 110 11 linear linear JJ cord-016990-ot1wi3xi 110 12 , , , cord-016990-ot1wi3xi 110 13 double double RB cord-016990-ot1wi3xi 110 14 - - HYPH cord-016990-ot1wi3xi 110 15 stranded strand VBN cord-016990-ot1wi3xi 110 16 DNA dna NN cord-016990-ot1wi3xi 110 17 genome genome NN cord-016990-ot1wi3xi 110 18 that that WDT cord-016990-ot1wi3xi 110 19 is be VBZ cord-016990-ot1wi3xi 110 20 contained contain VBN cord-016990-ot1wi3xi 110 21 within within IN cord-016990-ot1wi3xi 110 22 an an DT cord-016990-ot1wi3xi 110 23 icosahedral icosahedral JJ cord-016990-ot1wi3xi 110 24 capsid capsid NN cord-016990-ot1wi3xi 110 25 that that WDT cord-016990-ot1wi3xi 110 26 measures measure VBZ cord-016990-ot1wi3xi 110 27 70 70 CD cord-016990-ot1wi3xi 110 28 to to TO cord-016990-ot1wi3xi 110 29 90 90 CD cord-016990-ot1wi3xi 110 30 nm nm NN cord-016990-ot1wi3xi 110 31 in in IN cord-016990-ot1wi3xi 110 32 diameter diameter NN cord-016990-ot1wi3xi 111 1 ( ( -LRB- cord-016990-ot1wi3xi 111 2 Fig Fig NNP cord-016990-ot1wi3xi 111 3 . . . cord-016990-ot1wi3xi 111 4 ILIA ILIA NNP cord-016990-ot1wi3xi 111 5 ) ) -RRB- cord-016990-ot1wi3xi 111 6 . . . cord-016990-ot1wi3xi 112 1 The the DT cord-016990-ot1wi3xi 112 2 capsid capsid NN cord-016990-ot1wi3xi 112 3 is be VBZ cord-016990-ot1wi3xi 112 4 comprised comprise VBN cord-016990-ot1wi3xi 112 5 of of IN cord-016990-ot1wi3xi 112 6 seven seven CD cord-016990-ot1wi3xi 112 7 known know VBN cord-016990-ot1wi3xi 112 8 polypeptides polypeptide NNS cord-016990-ot1wi3xi 112 9 , , , cord-016990-ot1wi3xi 112 10 including include VBG cord-016990-ot1wi3xi 112 11 the the DT cord-016990-ot1wi3xi 112 12 hexon hexon NNP cord-016990-ot1wi3xi 112 13 capsomere capsomere NNP cord-016990-ot1wi3xi 112 14 , , , cord-016990-ot1wi3xi 112 15 which which WDT cord-016990-ot1wi3xi 112 16 contains contain VBZ cord-016990-ot1wi3xi 112 17 group group NN cord-016990-ot1wi3xi 112 18 - - HYPH cord-016990-ot1wi3xi 112 19 specific specific JJ cord-016990-ot1wi3xi 112 20 antigenic antigenic JJ cord-016990-ot1wi3xi 112 21 determinants determinant NNS cord-016990-ot1wi3xi 112 22 . . . cord-016990-ot1wi3xi 113 1 37 37 CD cord-016990-ot1wi3xi 113 2 Adenoviruses adenovirus NNS cord-016990-ot1wi3xi 113 3 are be VBP cord-016990-ot1wi3xi 113 4 a a DT cord-016990-ot1wi3xi 113 5 ubiquitous ubiquitous JJ cord-016990-ot1wi3xi 113 6 and and CC cord-016990-ot1wi3xi 113 7 diverse diverse JJ cord-016990-ot1wi3xi 113 8 group group NN cord-016990-ot1wi3xi 113 9 of of IN cord-016990-ot1wi3xi 113 10 viruses virus NNS cord-016990-ot1wi3xi 113 11 found find VBN cord-016990-ot1wi3xi 113 12 naturally naturally RB cord-016990-ot1wi3xi 113 13 in in IN cord-016990-ot1wi3xi 113 14 the the DT cord-016990-ot1wi3xi 113 15 upper upper JJ cord-016990-ot1wi3xi 113 16 respiratory respiratory JJ cord-016990-ot1wi3xi 113 17 tracts tract NNS cord-016990-ot1wi3xi 113 18 and and CC cord-016990-ot1wi3xi 113 19 gastrointestinal gastrointestinal JJ cord-016990-ot1wi3xi 113 20 systems system NNS cord-016990-ot1wi3xi 113 21 of of IN cord-016990-ot1wi3xi 113 22 humans human NNS cord-016990-ot1wi3xi 113 23 , , , cord-016990-ot1wi3xi 113 24 other other JJ cord-016990-ot1wi3xi 113 25 mammals mammal NNS cord-016990-ot1wi3xi 113 26 , , , cord-016990-ot1wi3xi 113 27 and and CC cord-016990-ot1wi3xi 113 28 birds bird NNS cord-016990-ot1wi3xi 113 29 . . . cord-016990-ot1wi3xi 114 1 Most Most JJS cord-016990-ot1wi3xi 114 2 adenoviruses adenovirus NNS cord-016990-ot1wi3xi 114 3 infect infect VBP cord-016990-ot1wi3xi 114 4 mucosal mucosal JJ cord-016990-ot1wi3xi 114 5 epithelium epithelium NN cord-016990-ot1wi3xi 114 6 , , , cord-016990-ot1wi3xi 114 7 although although IN cord-016990-ot1wi3xi 114 8 some some DT cord-016990-ot1wi3xi 114 9 pathogens pathogen NNS cord-016990-ot1wi3xi 114 10 of of IN cord-016990-ot1wi3xi 114 11 animals animal NNS cord-016990-ot1wi3xi 114 12 are be VBP cord-016990-ot1wi3xi 114 13 trophic trophic JJ cord-016990-ot1wi3xi 114 14 for for IN cord-016990-ot1wi3xi 114 15 endothelial endothelial JJ cord-016990-ot1wi3xi 114 16 cells cell NNS cord-016990-ot1wi3xi 114 17 , , , cord-016990-ot1wi3xi 114 18 and and CC cord-016990-ot1wi3xi 114 19 endothelial endothelial JJ cord-016990-ot1wi3xi 114 20 infection infection NN cord-016990-ot1wi3xi 114 21 has have VBZ cord-016990-ot1wi3xi 114 22 been be VBN cord-016990-ot1wi3xi 114 23 identified identify VBN cord-016990-ot1wi3xi 114 24 in in IN cord-016990-ot1wi3xi 114 25 some some DT cord-016990-ot1wi3xi 114 26 immunocompromised immunocompromised JJ cord-016990-ot1wi3xi 114 27 humans human NNS cord-016990-ot1wi3xi 114 28 . . . cord-016990-ot1wi3xi 115 1 38 38 CD cord-016990-ot1wi3xi 115 2 Adenoviruses adenovirus NNS cord-016990-ot1wi3xi 115 3 are be VBP cord-016990-ot1wi3xi 115 4 represented represent VBN cord-016990-ot1wi3xi 115 5 by by IN cord-016990-ot1wi3xi 115 6 at at RB cord-016990-ot1wi3xi 115 7 least least RBS cord-016990-ot1wi3xi 115 8 51 51 CD cord-016990-ot1wi3xi 115 9 serotypes serotype NNS cord-016990-ot1wi3xi 115 10 on on IN cord-016990-ot1wi3xi 115 11 the the DT cord-016990-ot1wi3xi 115 12 basis basis NN cord-016990-ot1wi3xi 115 13 of of IN cord-016990-ot1wi3xi 115 14 resistance resistance NN cord-016990-ot1wi3xi 115 15 to to IN cord-016990-ot1wi3xi 115 16 neutralization neutralization NN cord-016990-ot1wi3xi 115 17 by by IN cord-016990-ot1wi3xi 115 18 antisera antisera NN cord-016990-ot1wi3xi 115 19 to to IN cord-016990-ot1wi3xi 115 20 other other JJ cord-016990-ot1wi3xi 115 21 known know VBN cord-016990-ot1wi3xi 115 22 adenovirus adenovirus NN cord-016990-ot1wi3xi 115 23 serotypes serotype NNS cord-016990-ot1wi3xi 115 24 , , , cord-016990-ot1wi3xi 115 25 and and CC cord-016990-ot1wi3xi 115 26 comprise comprise VBP cord-016990-ot1wi3xi 115 27 six six CD cord-016990-ot1wi3xi 115 28 subgroups subgroup NNS cord-016990-ot1wi3xi 115 29 or or CC cord-016990-ot1wi3xi 115 30 subgenera subgenus NNS cord-016990-ot1wi3xi 115 31 ( ( -LRB- cord-016990-ot1wi3xi 115 32 A a NN cord-016990-ot1wi3xi 115 33 through through IN cord-016990-ot1wi3xi 115 34 F F NNP cord-016990-ot1wi3xi 115 35 ) ) -RRB- cord-016990-ot1wi3xi 115 36 that that WDT cord-016990-ot1wi3xi 115 37 are be VBP cord-016990-ot1wi3xi 115 38 distinguished distinguish VBN cord-016990-ot1wi3xi 115 39 by by IN cord-016990-ot1wi3xi 115 40 differential differential JJ cord-016990-ot1wi3xi 115 41 hemagglutination hemagglutination NN cord-016990-ot1wi3xi 115 42 with with IN cord-016990-ot1wi3xi 115 43 erythrocytes erythrocyte NNS cord-016990-ot1wi3xi 115 44 from from IN cord-016990-ot1wi3xi 115 45 various various JJ cord-016990-ot1wi3xi 115 46 animal animal NN cord-016990-ot1wi3xi 115 47 species specie NNS cord-016990-ot1wi3xi 115 48 . . . cord-016990-ot1wi3xi 116 1 37 37 CD cord-016990-ot1wi3xi 116 2 , , , cord-016990-ot1wi3xi 116 3 39Ao 39ao CD cord-016990-ot1wi3xi 116 4 More More JJR cord-016990-ot1wi3xi 116 5 than than IN cord-016990-ot1wi3xi 116 6 50 50 CD cord-016990-ot1wi3xi 116 7 % % NN cord-016990-ot1wi3xi 116 8 of of IN cord-016990-ot1wi3xi 116 9 the the DT cord-016990-ot1wi3xi 116 10 known know VBN cord-016990-ot1wi3xi 116 11 adenovirus adenovirus NN cord-016990-ot1wi3xi 116 12 serotypes serotype NNS cord-016990-ot1wi3xi 116 13 are be VBP cord-016990-ot1wi3xi 116 14 associated associate VBN cord-016990-ot1wi3xi 116 15 with with IN cord-016990-ot1wi3xi 116 16 human human JJ cord-016990-ot1wi3xi 116 17 diseases disease NNS cord-016990-ot1wi3xi 116 18 of of IN cord-016990-ot1wi3xi 116 19 the the DT cord-016990-ot1wi3xi 116 20 upper upper JJ cord-016990-ot1wi3xi 116 21 and and CC cord-016990-ot1wi3xi 116 22 lower low JJR cord-016990-ot1wi3xi 116 23 respiratory respiratory JJ cord-016990-ot1wi3xi 116 24 tract tract NN cord-016990-ot1wi3xi 116 25 , , , cord-016990-ot1wi3xi 116 26 conjunctiva conjunctiva NN cord-016990-ot1wi3xi 116 27 , , , cord-016990-ot1wi3xi 116 28 urinary urinary JJ cord-016990-ot1wi3xi 116 29 tract tract NN cord-016990-ot1wi3xi 116 30 , , , cord-016990-ot1wi3xi 116 31 intestine intestine NN cord-016990-ot1wi3xi 116 32 , , , cord-016990-ot1wi3xi 116 33 and and CC cord-016990-ot1wi3xi 116 34 occasionally occasionally RB cord-016990-ot1wi3xi 116 35 heart heart NN cord-016990-ot1wi3xi 116 36 , , , cord-016990-ot1wi3xi 116 37 liver liver NN cord-016990-ot1wi3xi 116 38 , , , cord-016990-ot1wi3xi 116 39 and and CC cord-016990-ot1wi3xi 116 40 central central JJ cord-016990-ot1wi3xi 116 41 nervous nervous JJ cord-016990-ot1wi3xi 116 42 system system NN cord-016990-ot1wi3xi 116 43 . . . cord-016990-ot1wi3xi 117 1 The the DT cord-016990-ot1wi3xi 117 2 others other NNS cord-016990-ot1wi3xi 117 3 are be VBP cord-016990-ot1wi3xi 117 4 rarely rarely RB cord-016990-ot1wi3xi 117 5 encountered encounter VBN cord-016990-ot1wi3xi 117 6 and and CC cord-016990-ot1wi3xi 117 7 mayor mayor NN cord-016990-ot1wi3xi 117 8 may may MD cord-016990-ot1wi3xi 117 9 not not RB cord-016990-ot1wi3xi 117 10 act act VB cord-016990-ot1wi3xi 117 11 as as IN cord-016990-ot1wi3xi 117 12 pathogens pathogen NNS cord-016990-ot1wi3xi 117 13 in in IN cord-016990-ot1wi3xi 117 14 recognizable recognizable JJ cord-016990-ot1wi3xi 117 15 disease disease NN cord-016990-ot1wi3xi 117 16 . . . cord-016990-ot1wi3xi 118 1 37 37 CD cord-016990-ot1wi3xi 119 1 It -PRON- PRP cord-016990-ot1wi3xi 119 2 is be VBZ cord-016990-ot1wi3xi 119 3 estimated estimate VBN cord-016990-ot1wi3xi 119 4 that that IN cord-016990-ot1wi3xi 119 5 approximately approximately RB cord-016990-ot1wi3xi 119 6 5 5 CD cord-016990-ot1wi3xi 119 7 % % NN cord-016990-ot1wi3xi 119 8 to to TO cord-016990-ot1wi3xi 119 9 10 10 CD cord-016990-ot1wi3xi 119 10 % % NN cord-016990-ot1wi3xi 119 11 of of IN cord-016990-ot1wi3xi 119 12 all all DT cord-016990-ot1wi3xi 119 13 pneumonias pneumonia NNS cord-016990-ot1wi3xi 119 14 in in IN cord-016990-ot1wi3xi 119 15 infants infant NNS cord-016990-ot1wi3xi 119 16 and and CC cord-016990-ot1wi3xi 119 17 young young JJ cord-016990-ot1wi3xi 119 18 children child NNS cord-016990-ot1wi3xi 119 19 are be VBP cord-016990-ot1wi3xi 119 20 caused cause VBN cord-016990-ot1wi3xi 119 21 by by IN cord-016990-ot1wi3xi 119 22 adenoviruses adenovirus NNS cord-016990-ot1wi3xi 119 23 . . . cord-016990-ot1wi3xi 120 1 41 41 CD cord-016990-ot1wi3xi 120 2 , , , cord-016990-ot1wi3xi 120 3 42 42 CD cord-016990-ot1wi3xi 120 4 Most most RBS cord-016990-ot1wi3xi 120 5 pediatric pediatric JJ cord-016990-ot1wi3xi 120 6 cases case NNS cord-016990-ot1wi3xi 120 7 of of IN cord-016990-ot1wi3xi 120 8 adenovirus adenovirus NN cord-016990-ot1wi3xi 120 9 pneumonia pneumonia NN cord-016990-ot1wi3xi 120 10 occur occur VBP cord-016990-ot1wi3xi 120 11 between between IN cord-016990-ot1wi3xi 120 12 6 6 CD cord-016990-ot1wi3xi 120 13 months month NNS cord-016990-ot1wi3xi 120 14 and and CC cord-016990-ot1wi3xi 120 15 5 5 CD cord-016990-ot1wi3xi 120 16 years year NNS cord-016990-ot1wi3xi 120 17 of of IN cord-016990-ot1wi3xi 120 18 age age NN cord-016990-ot1wi3xi 120 19 , , , cord-016990-ot1wi3xi 120 20 and and CC cord-016990-ot1wi3xi 120 21 serotypes serotypes NN cord-016990-ot1wi3xi 120 22 3 3 CD cord-016990-ot1wi3xi 120 23 , , , cord-016990-ot1wi3xi 120 24 7 7 CD cord-016990-ot1wi3xi 120 25 , , , cord-016990-ot1wi3xi 120 26 and and CC cord-016990-ot1wi3xi 120 27 21 21 CD cord-016990-ot1wi3xi 120 28 ( ( -LRB- cord-016990-ot1wi3xi 120 29 all all DT cord-016990-ot1wi3xi 120 30 members member NNS cord-016990-ot1wi3xi 120 31 of of IN cord-016990-ot1wi3xi 120 32 the the DT cord-016990-ot1wi3xi 120 33 B b NN cord-016990-ot1wi3xi 120 34 subgenus subgenus NN cord-016990-ot1wi3xi 120 35 ) ) -RRB- cord-016990-ot1wi3xi 120 36 , , , cord-016990-ot1wi3xi 120 37 are be VBP cord-016990-ot1wi3xi 120 38 the the DT cord-016990-ot1wi3xi 120 39 most most RBS cord-016990-ot1wi3xi 120 40 common common JJ cord-016990-ot1wi3xi 120 41 causes cause NNS cord-016990-ot1wi3xi 120 42 of of IN cord-016990-ot1wi3xi 120 43 pneumonia pneumonia NN cord-016990-ot1wi3xi 120 44 in in IN cord-016990-ot1wi3xi 120 45 this this DT cord-016990-ot1wi3xi 120 46 patient patient JJ cord-016990-ot1wi3xi 120 47 cohort cohort NN cord-016990-ot1wi3xi 120 48 . . . cord-016990-ot1wi3xi 121 1 43 43 CD cord-016990-ot1wi3xi 122 1 -45 -45 NNP cord-016990-ot1wi3xi 123 1 Serotypes serotypes NN cord-016990-ot1wi3xi 123 2 3 3 CD cord-016990-ot1wi3xi 123 3 and and CC cord-016990-ot1wi3xi 123 4 7 7 CD cord-016990-ot1wi3xi 123 5 are be VBP cord-016990-ot1wi3xi 123 6 particularly particularly RB cord-016990-ot1wi3xi 123 7 pathogenic pathogenic JJ cord-016990-ot1wi3xi 123 8 adenoviruses adenovirus NNS cord-016990-ot1wi3xi 123 9 that that WDT cord-016990-ot1wi3xi 123 10 can can MD cord-016990-ot1wi3xi 123 11 cause cause VB cord-016990-ot1wi3xi 123 12 disseminated disseminate VBN cord-016990-ot1wi3xi 123 13 and and CC cord-016990-ot1wi3xi 123 14 often often RB cord-016990-ot1wi3xi 123 15 fatal fatal JJ cord-016990-ot1wi3xi 123 16 disease disease NN cord-016990-ot1wi3xi 123 17 in in IN cord-016990-ot1wi3xi 123 18 previously previously RB cord-016990-ot1wi3xi 123 19 healthy healthy JJ cord-016990-ot1wi3xi 123 20 children child NNS cord-016990-ot1wi3xi 123 21 . . . cord-016990-ot1wi3xi 124 1 46 46 CD cord-016990-ot1wi3xi 125 1 In in IN cord-016990-ot1wi3xi 125 2 adults adult NNS cord-016990-ot1wi3xi 125 3 , , , cord-016990-ot1wi3xi 125 4 pneumonia pneumonia NN cord-016990-ot1wi3xi 125 5 is be VBZ cord-016990-ot1wi3xi 125 6 generally generally RB cord-016990-ot1wi3xi 125 7 associated associate VBN cord-016990-ot1wi3xi 125 8 with with IN cord-016990-ot1wi3xi 125 9 serotypes serotypes CD cord-016990-ot1wi3xi 125 10 3,4 3,4 CD cord-016990-ot1wi3xi 125 11 , , , cord-016990-ot1wi3xi 125 12 and and CC cord-016990-ot1wi3xi 125 13 7.47 7.47 CD cord-016990-ot1wi3xi 125 14 Periodic periodic JJ cord-016990-ot1wi3xi 125 15 epidemics epidemic NNS cord-016990-ot1wi3xi 125 16 of of IN cord-016990-ot1wi3xi 125 17 adenovirus adenovirus NN cord-016990-ot1wi3xi 125 18 pneumonia pneumonia NN cord-016990-ot1wi3xi 125 19 in in IN cord-016990-ot1wi3xi 125 20 young young JJ cord-016990-ot1wi3xi 125 21 adults adult NNS cord-016990-ot1wi3xi 125 22 have have VBP cord-016990-ot1wi3xi 125 23 been be VBN cord-016990-ot1wi3xi 125 24 identified identify VBN cord-016990-ot1wi3xi 125 25 , , , cord-016990-ot1wi3xi 125 26 particularly particularly RB cord-016990-ot1wi3xi 125 27 among among IN cord-016990-ot1wi3xi 125 28 military military JJ cord-016990-ot1wi3xi 125 29 recruits recruit NNS cord-016990-ot1wi3xi 125 30 . . . cord-016990-ot1wi3xi 126 1 48 48 CD cord-016990-ot1wi3xi 126 2 , , , cord-016990-ot1wi3xi 126 3 49 49 CD cord-016990-ot1wi3xi 127 1 In in IN cord-016990-ot1wi3xi 127 2 a a DT cord-016990-ot1wi3xi 127 3 manner manner NN cord-016990-ot1wi3xi 127 4 similar similar JJ cord-016990-ot1wi3xi 127 5 to to IN cord-016990-ot1wi3xi 127 6 other other JJ cord-016990-ot1wi3xi 127 7 pathogens pathogen NNS cord-016990-ot1wi3xi 127 8 , , , cord-016990-ot1wi3xi 127 9 adenoviruses adenovirus NNS cord-016990-ot1wi3xi 127 10 take take VBP cord-016990-ot1wi3xi 127 11 advantage advantage NN cord-016990-ot1wi3xi 127 12 of of IN cord-016990-ot1wi3xi 127 13 impaired impaired JJ cord-016990-ot1wi3xi 127 14 or or CC cord-016990-ot1wi3xi 127 15 destroyed destroy VBN cord-016990-ot1wi3xi 127 16 immune immune JJ cord-016990-ot1wi3xi 127 17 systems system NNS cord-016990-ot1wi3xi 127 18 to to TO cord-016990-ot1wi3xi 127 19 establish establish VB cord-016990-ot1wi3xi 127 20 persistent persistent JJ cord-016990-ot1wi3xi 127 21 and and CC cord-016990-ot1wi3xi 127 22 disseminated disseminate VBN cord-016990-ot1wi3xi 127 23 infections infection NNS cord-016990-ot1wi3xi 127 24 in in IN cord-016990-ot1wi3xi 127 25 immunocompromised immunocompromised JJ cord-016990-ot1wi3xi 127 26 hosts host NNS cord-016990-ot1wi3xi 127 27 . . . cord-016990-ot1wi3xi 128 1 In in IN cord-016990-ot1wi3xi 128 2 this this DT cord-016990-ot1wi3xi 128 3 patient patient JJ cord-016990-ot1wi3xi 128 4 cohort cohort NN cord-016990-ot1wi3xi 128 5 , , , cord-016990-ot1wi3xi 128 6 the the DT cord-016990-ot1wi3xi 128 7 S.R. S.R. NNP cord-016990-ot1wi3xi 128 8 Zaki Zaki NNP cord-016990-ot1wi3xi 128 9 and and CC cord-016990-ot1wi3xi 128 10 CD CD NNP cord-016990-ot1wi3xi 128 11 . . . cord-016990-ot1wi3xi 129 1 Paddock paddock NN cord-016990-ot1wi3xi 129 2 case case NN cord-016990-ot1wi3xi 129 3 fatality fatality NN cord-016990-ot1wi3xi 129 4 rate rate NN cord-016990-ot1wi3xi 129 5 of of IN cord-016990-ot1wi3xi 129 6 adenoviral adenoviral JJ cord-016990-ot1wi3xi 129 7 pneumonia pneumonia NN cord-016990-ot1wi3xi 129 8 approaches approach VBZ cord-016990-ot1wi3xi 129 9 60 60 CD cord-016990-ot1wi3xi 129 10 % % NN cord-016990-ot1wi3xi 129 11 , , , cord-016990-ot1wi3xi 129 12 compared compare VBN cord-016990-ot1wi3xi 129 13 with with IN cord-016990-ot1wi3xi 129 14 an an DT cord-016990-ot1wi3xi 129 15 approximately approximately RB cord-016990-ot1wi3xi 129 16 15 15 CD cord-016990-ot1wi3xi 129 17 % % NN cord-016990-ot1wi3xi 129 18 mortality mortality NN cord-016990-ot1wi3xi 129 19 in in IN cord-016990-ot1wi3xi 129 20 immunocompetent immunocompetent JJ cord-016990-ot1wi3xi 129 21 patients patient NNS cord-016990-ot1wi3xi 129 22 . . . cord-016990-ot1wi3xi 130 1 37 37 CD cord-016990-ot1wi3xi 131 1 Immunocompromised immunocompromise VBN cord-016990-ot1wi3xi 131 2 patients patient NNS cord-016990-ot1wi3xi 131 3 are be VBP cord-016990-ot1wi3xi 131 4 also also RB cord-016990-ot1wi3xi 131 5 susceptible susceptible JJ cord-016990-ot1wi3xi 131 6 to to IN cord-016990-ot1wi3xi 131 7 a a DT cord-016990-ot1wi3xi 131 8 broader broad JJR cord-016990-ot1wi3xi 131 9 range range NN cord-016990-ot1wi3xi 131 10 of of IN cord-016990-ot1wi3xi 131 11 different different JJ cord-016990-ot1wi3xi 131 12 adenovirus adenovirus NN cord-016990-ot1wi3xi 131 13 serotypes serotype NNS cord-016990-ot1wi3xi 131 14 . . . cord-016990-ot1wi3xi 132 1 By by IN cord-016990-ot1wi3xi 132 2 example example NN cord-016990-ot1wi3xi 132 3 , , , cord-016990-ot1wi3xi 132 4 the the DT cord-016990-ot1wi3xi 132 5 commonly commonly RB cord-016990-ot1wi3xi 132 6 recognized recognize VBN cord-016990-ot1wi3xi 132 7 serotypes serotype NNS cord-016990-ot1wi3xi 132 8 in in IN cord-016990-ot1wi3xi 132 9 normal normal JJ cord-016990-ot1wi3xi 132 10 children child NNS cord-016990-ot1wi3xi 132 11 account account VBP cord-016990-ot1wi3xi 132 12 for for IN cord-016990-ot1wi3xi 132 13 only only RB cord-016990-ot1wi3xi 132 14 about about RB cord-016990-ot1wi3xi 132 15 50 50 CD cord-016990-ot1wi3xi 132 16 % % NN cord-016990-ot1wi3xi 132 17 of of IN cord-016990-ot1wi3xi 132 18 the the DT cord-016990-ot1wi3xi 132 19 adenovirus adenovirus NN cord-016990-ot1wi3xi 132 20 serotypes serotype NNS cord-016990-ot1wi3xi 132 21 reported report VBN cord-016990-ot1wi3xi 132 22 for for IN cord-016990-ot1wi3xi 132 23 children child NNS cord-016990-ot1wi3xi 132 24 with with IN cord-016990-ot1wi3xi 132 25 congenital congenital JJ cord-016990-ot1wi3xi 132 26 immune immune JJ cord-016990-ot1wi3xi 132 27 deficiencies deficiency NNS cord-016990-ot1wi3xi 132 28 . . . cord-016990-ot1wi3xi 133 1 37 37 CD cord-016990-ot1wi3xi 133 2 .4 .4 CD cord-016990-ot1wi3xi 133 3 6 6 CD cord-016990-ot1wi3xi 134 1 Because because IN cord-016990-ot1wi3xi 134 2 some some DT cord-016990-ot1wi3xi 134 3 adenoviruses adenovirus NNS cord-016990-ot1wi3xi 134 4 establish establish VBP cord-016990-ot1wi3xi 134 5 latency latency NN cord-016990-ot1wi3xi 134 6 in in IN cord-016990-ot1wi3xi 134 7 lymphoid lymphoid JJ cord-016990-ot1wi3xi 134 8 tissues tissue NNS cord-016990-ot1wi3xi 134 9 and and CC cord-016990-ot1wi3xi 134 10 the the DT cord-016990-ot1wi3xi 134 11 kidneys kidney NNS cord-016990-ot1wi3xi 134 12 of of IN cord-016990-ot1wi3xi 134 13 their -PRON- PRP$ cord-016990-ot1wi3xi 134 14 host host NN cord-016990-ot1wi3xi 134 15 , , , cord-016990-ot1wi3xi 134 16 it -PRON- PRP cord-016990-ot1wi3xi 134 17 is be VBZ cord-016990-ot1wi3xi 134 18 believed believe VBN cord-016990-ot1wi3xi 134 19 that that IN cord-016990-ot1wi3xi 134 20 many many JJ cord-016990-ot1wi3xi 134 21 , , , cord-016990-ot1wi3xi 134 22 possibly possibly RB cord-016990-ot1wi3xi 134 23 most most JJS cord-016990-ot1wi3xi 134 24 , , , cord-016990-ot1wi3xi 134 25 cases case NNS cord-016990-ot1wi3xi 134 26 of of IN cord-016990-ot1wi3xi 134 27 clinical clinical JJ cord-016990-ot1wi3xi 134 28 disease disease NN cord-016990-ot1wi3xi 134 29 caused cause VBN cord-016990-ot1wi3xi 134 30 by by IN cord-016990-ot1wi3xi 134 31 adenoviruses adenovirus NNS cord-016990-ot1wi3xi 134 32 in in IN cord-016990-ot1wi3xi 134 33 immunocompromised immunocompromised JJ cord-016990-ot1wi3xi 134 34 patients patient NNS cord-016990-ot1wi3xi 134 35 are be VBP cord-016990-ot1wi3xi 134 36 reactivated reactivate VBN cord-016990-ot1wi3xi 134 37 infections infection NNS cord-016990-ot1wi3xi 134 38 . . . cord-016990-ot1wi3xi 135 1 37 37 CD cord-016990-ot1wi3xi 136 1 The the DT cord-016990-ot1wi3xi 136 2 lungs lung NNS cord-016990-ot1wi3xi 136 3 of of IN cord-016990-ot1wi3xi 136 4 patients patient NNS cord-016990-ot1wi3xi 136 5 with with IN cord-016990-ot1wi3xi 136 6 adenovirus adenovirus NN cord-016990-ot1wi3xi 136 7 pneumonia pneumonia NN cord-016990-ot1wi3xi 136 8 are be VBP cord-016990-ot1wi3xi 136 9 typically typically RB cord-016990-ot1wi3xi 136 10 heavy heavy JJ cord-016990-ot1wi3xi 136 11 and and CC cord-016990-ot1wi3xi 136 12 edematous edematous JJ cord-016990-ot1wi3xi 136 13 , , , cord-016990-ot1wi3xi 136 14 and and CC cord-016990-ot1wi3xi 136 15 the the DT cord-016990-ot1wi3xi 136 16 bronchi bronchi NN cord-016990-ot1wi3xi 136 17 are be VBP cord-016990-ot1wi3xi 136 18 generally generally RB cord-016990-ot1wi3xi 136 19 filled fill VBN cord-016990-ot1wi3xi 136 20 with with IN cord-016990-ot1wi3xi 136 21 mucoid mucoid NNP cord-016990-ot1wi3xi 136 22 , , , cord-016990-ot1wi3xi 136 23 fibrinous fibrinous JJ cord-016990-ot1wi3xi 136 24 , , , cord-016990-ot1wi3xi 136 25 or or CC cord-016990-ot1wi3xi 136 26 purulent purulent JJ cord-016990-ot1wi3xi 136 27 exudates exudate NNS cord-016990-ot1wi3xi 136 28 . . . cord-016990-ot1wi3xi 137 1 The the DT cord-016990-ot1wi3xi 137 2 histopathologic histopathologic JJ cord-016990-ot1wi3xi 137 3 findings finding NNS cord-016990-ot1wi3xi 137 4 ( ( -LRB- cord-016990-ot1wi3xi 137 5 Fig Fig NNP cord-016990-ot1wi3xi 137 6 . . . cord-016990-ot1wi3xi 137 7 11 11 CD cord-016990-ot1wi3xi 137 8 .2 .2 NFP cord-016990-ot1wi3xi 137 9 ) ) -RRB- cord-016990-ot1wi3xi 137 10 include include VBP cord-016990-ot1wi3xi 137 11 necrotizing necrotize VBG cord-016990-ot1wi3xi 137 12 bronchitis bronchitis NN cord-016990-ot1wi3xi 137 13 and and CC cord-016990-ot1wi3xi 137 14 bronchiolitis bronchiolitis NN cord-016990-ot1wi3xi 137 15 with with IN cord-016990-ot1wi3xi 137 16 extensive extensive JJ cord-016990-ot1wi3xi 137 17 denudation denudation NN cord-016990-ot1wi3xi 137 18 ofthe ofthe DT cord-016990-ot1wi3xi 137 19 surface surface NN cord-016990-ot1wi3xi 137 20 epithelium epithelium NN cord-016990-ot1wi3xi 137 21 , , , cord-016990-ot1wi3xi 137 22 particularly particularly RB cord-016990-ot1wi3xi 137 23 in in IN cord-016990-ot1wi3xi 137 24 medium medium JJ cord-016990-ot1wi3xi 137 25 - - HYPH cord-016990-ot1wi3xi 137 26 sized sized JJ cord-016990-ot1wi3xi 137 27 ( ( -LRB- cord-016990-ot1wi3xi 137 28 1 1 CD cord-016990-ot1wi3xi 137 29 to to IN cord-016990-ot1wi3xi 137 30 2 2 CD cord-016990-ot1wi3xi 137 31 mm mm NNS cord-016990-ot1wi3xi 137 32 in in IN cord-016990-ot1wi3xi 137 33 diameter diameter NN cord-016990-ot1wi3xi 137 34 ) ) -RRB- cord-016990-ot1wi3xi 138 1 intrapulmonary intrapulmonary NNP cord-016990-ot1wi3xi 138 2 bronchi bronchi NNP cord-016990-ot1wi3xi 138 3 ( ( -LRB- cord-016990-ot1wi3xi 138 4 Fig Fig NNP cord-016990-ot1wi3xi 138 5 . . . cord-016990-ot1wi3xi 138 6 _SP cord-016990-ot1wi3xi 138 7 11 11 CD cord-016990-ot1wi3xi 138 8 .2A .2A . cord-016990-ot1wi3xi 138 9 ) ) -RRB- cord-016990-ot1wi3xi 138 10 . . . cord-016990-ot1wi3xi 139 1 Affected affected JJ cord-016990-ot1wi3xi 139 2 airways airway NNS cord-016990-ot1wi3xi 139 3 may may MD cord-016990-ot1wi3xi 139 4 be be VB cord-016990-ot1wi3xi 139 5 occluded occlude VBN cord-016990-ot1wi3xi 139 6 by by IN cord-016990-ot1wi3xi 139 7 homogeneous homogeneous JJ cord-016990-ot1wi3xi 139 8 eosinophilic eosinophilic JJ cord-016990-ot1wi3xi 139 9 material material NN cord-016990-ot1wi3xi 139 10 , , , cord-016990-ot1wi3xi 139 11 mixed mix VBN cord-016990-ot1wi3xi 139 12 inflammatory inflammatory JJ cord-016990-ot1wi3xi 139 13 cells cell NNS cord-016990-ot1wi3xi 139 14 , , , cord-016990-ot1wi3xi 139 15 detached detached JJ cord-016990-ot1wi3xi 139 16 epithelium epithelium NN cord-016990-ot1wi3xi 139 17 , , , cord-016990-ot1wi3xi 139 18 and and CC cord-016990-ot1wi3xi 139 19 cellular cellular JJ cord-016990-ot1wi3xi 139 20 debris debris NN cord-016990-ot1wi3xi 139 21 . . . cord-016990-ot1wi3xi 140 1 The the DT cord-016990-ot1wi3xi 140 2 lamina lamina JJ cord-016990-ot1wi3xi 140 3 propria propria NN cord-016990-ot1wi3xi 140 4 of of IN cord-016990-ot1wi3xi 140 5 bronchi bronchi NN cord-016990-ot1wi3xi 140 6 and and CC cord-016990-ot1wi3xi 140 7 bronchioles bronchiole NNS cord-016990-ot1wi3xi 140 8 is be VBZ cord-016990-ot1wi3xi 140 9 typically typically RB cord-016990-ot1wi3xi 140 10 congested congest VBN cord-016990-ot1wi3xi 140 11 and and CC cord-016990-ot1wi3xi 140 12 infiltrated infiltrate VBN cord-016990-ot1wi3xi 140 13 by by IN cord-016990-ot1wi3xi 140 14 predominantly predominantly RB cord-016990-ot1wi3xi 140 15 mononuclear mononuclear JJ cord-016990-ot1wi3xi 140 16 inflammatory inflammatory JJ cord-016990-ot1wi3xi 140 17 cell cell NN cord-016990-ot1wi3xi 140 18 infiltrates infiltrate VBZ cord-016990-ot1wi3xi 140 19 . . . cord-016990-ot1wi3xi 141 1 Bronchial bronchial JJ cord-016990-ot1wi3xi 141 2 serous serous JJ cord-016990-ot1wi3xi 141 3 and and CC cord-016990-ot1wi3xi 141 4 mucous mucous JJ cord-016990-ot1wi3xi 141 5 glands gland NNS cord-016990-ot1wi3xi 141 6 are be VBP cord-016990-ot1wi3xi 141 7 also also RB cord-016990-ot1wi3xi 141 8 often often RB cord-016990-ot1wi3xi 141 9 involved involve VBN cord-016990-ot1wi3xi 141 10 and and CC cord-016990-ot1wi3xi 141 11 show show VBP cord-016990-ot1wi3xi 141 12 necrosis necrosis NN cord-016990-ot1wi3xi 141 13 and and CC cord-016990-ot1wi3xi 141 14 mixed mixed JJ cord-016990-ot1wi3xi 141 15 infiltrates infiltrate NNS cord-016990-ot1wi3xi 141 16 . . . cord-016990-ot1wi3xi 142 1 5o 5o NNS cord-016990-ot1wi3xi 143 1 As as IN cord-016990-ot1wi3xi 143 2 the the DT cord-016990-ot1wi3xi 143 3 infection infection NN cord-016990-ot1wi3xi 143 4 progresses progress VBZ cord-016990-ot1wi3xi 143 5 , , , cord-016990-ot1wi3xi 143 6 there there EX cord-016990-ot1wi3xi 143 7 is be VBZ cord-016990-ot1wi3xi 143 8 involvement involvement NN cord-016990-ot1wi3xi 143 9 of of IN cord-016990-ot1wi3xi 143 10 the the DT cord-016990-ot1wi3xi 143 11 pulmonary pulmonary JJ cord-016990-ot1wi3xi 143 12 parenchyma parenchyma NN cord-016990-ot1wi3xi 143 13 , , , cord-016990-ot1wi3xi 143 14 forming form VBG cord-016990-ot1wi3xi 143 15 bronchocentric bronchocentric JJ cord-016990-ot1wi3xi 143 16 necrosis necrosis NN cord-016990-ot1wi3xi 143 17 with with IN cord-016990-ot1wi3xi 143 18 hemorrhage hemorrhage NN cord-016990-ot1wi3xi 143 19 , , , cord-016990-ot1wi3xi 143 20 neutrophilic neutrophilic JJ cord-016990-ot1wi3xi 143 21 and and CC cord-016990-ot1wi3xi 143 22 mononuclear mononuclear JJ cord-016990-ot1wi3xi 143 23 cell cell NN cord-016990-ot1wi3xi 143 24 infiltrates infiltrate VBZ cord-016990-ot1wi3xi 143 25 , , , cord-016990-ot1wi3xi 143 26 and and CC cord-016990-ot1wi3xi 143 27 karyorrhexis karyorrhexis NNP cord-016990-ot1wi3xi 143 28 . . . cord-016990-ot1wi3xi 144 1 These these DT cord-016990-ot1wi3xi 144 2 findings finding NNS cord-016990-ot1wi3xi 144 3 generally generally RB cord-016990-ot1wi3xi 144 4 occur occur VBP cord-016990-ot1wi3xi 144 5 against against IN cord-016990-ot1wi3xi 144 6 a a DT cord-016990-ot1wi3xi 144 7 background background NN cord-016990-ot1wi3xi 144 8 of of IN cord-016990-ot1wi3xi 144 9 exudative exudative JJ cord-016990-ot1wi3xi 144 10 diffuse diffuse JJ cord-016990-ot1wi3xi 144 11 alveolar alveolar NN cord-016990-ot1wi3xi 144 12 damage damage NN cord-016990-ot1wi3xi 144 13 , , , cord-016990-ot1wi3xi 144 14 with with IN cord-016990-ot1wi3xi 144 15 filling filling NN cord-016990-ot1wi3xi 144 16 of of IN cord-016990-ot1wi3xi 144 17 the the DT cord-016990-ot1wi3xi 144 18 air air NN cord-016990-ot1wi3xi 144 19 space space NN cord-016990-ot1wi3xi 144 20 by by IN cord-016990-ot1wi3xi 144 21 macrophages macrophage NNS cord-016990-ot1wi3xi 144 22 , , , cord-016990-ot1wi3xi 144 23 fibrin fibrin NN cord-016990-ot1wi3xi 144 24 , , , cord-016990-ot1wi3xi 144 25 and and CC cord-016990-ot1wi3xi 144 26 detached detached JJ cord-016990-ot1wi3xi 144 27 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 144 28 , , , cord-016990-ot1wi3xi 144 29 and and CC cord-016990-ot1wi3xi 144 30 hyaline hyaline JJ cord-016990-ot1wi3xi 144 31 membrane membrane NN cord-016990-ot1wi3xi 144 32 formation formation NN cord-016990-ot1wi3xi 144 33 . . . cord-016990-ot1wi3xi 145 1 51 51 CD cord-016990-ot1wi3xi 145 2 Patients patient NNS cord-016990-ot1wi3xi 145 3 with with IN cord-016990-ot1wi3xi 145 4 fatal fatal JJ cord-016990-ot1wi3xi 145 5 pneumonia pneumonia NN cord-016990-ot1wi3xi 145 6 may may MD cord-016990-ot1wi3xi 145 7 develop develop VB cord-016990-ot1wi3xi 145 8 disseminated disseminate VBN cord-016990-ot1wi3xi 145 9 intravascular intravascular JJ cord-016990-ot1wi3xi 145 10 coagulopathy coagulopathy NN cord-016990-ot1wi3xi 145 11 and and CC cord-016990-ot1wi3xi 145 12 demonstrate demonstrate VB cord-016990-ot1wi3xi 145 13 fibrin fibrin NN cord-016990-ot1wi3xi 145 14 thrombi thrombi NN cord-016990-ot1wi3xi 145 15 in in IN cord-016990-ot1wi3xi 145 16 vessels vessel NNS cord-016990-ot1wi3xi 145 17 of of IN cord-016990-ot1wi3xi 145 18 the the DT cord-016990-ot1wi3xi 145 19 lungs lung NNS cord-016990-ot1wi3xi 145 20 , , , cord-016990-ot1wi3xi 145 21 kidney kidney NN cord-016990-ot1wi3xi 145 22 , , , cord-016990-ot1wi3xi 145 23 heart heart NN cord-016990-ot1wi3xi 145 24 , , , cord-016990-ot1wi3xi 145 25 adrenals adrenal NNS cord-016990-ot1wi3xi 145 26 , , , cord-016990-ot1wi3xi 145 27 and and CC cord-016990-ot1wi3xi 145 28 central central JJ cord-016990-ot1wi3xi 145 29 nervous nervous JJ cord-016990-ot1wi3xi 145 30 system system NN cord-016990-ot1wi3xi 145 31 ( ( -LRB- cord-016990-ot1wi3xi 145 32 see see VB cord-016990-ot1wi3xi 145 33 Fig Fig NNP cord-016990-ot1wi3xi 145 34 . . . cord-016990-ot1wi3xi 146 1 4 4 LS cord-016990-ot1wi3xi 146 2 .20 .20 CD cord-016990-ot1wi3xi 146 3 in in IN cord-016990-ot1wi3xi 146 4 Chapter chapter NN cord-016990-ot1wi3xi 146 5 4 4 CD cord-016990-ot1wi3xi 146 6 ) ) -RRB- cord-016990-ot1wi3xi 146 7 . . . cord-016990-ot1wi3xi 147 1 48 48 CD cord-016990-ot1wi3xi 147 2 Adenoviruses adenovirus NNS cord-016990-ot1wi3xi 147 3 form form VBP cord-016990-ot1wi3xi 147 4 intranuclear intranuclear NN cord-016990-ot1wi3xi 147 5 inclusions inclusion NNS cord-016990-ot1wi3xi 147 6 in in IN cord-016990-ot1wi3xi 147 7 respiratory respiratory JJ cord-016990-ot1wi3xi 147 8 epithelial epithelial JJ cord-016990-ot1wi3xi 147 9 cells cell NNS cord-016990-ot1wi3xi 147 10 of of IN cord-016990-ot1wi3xi 147 11 the the DT cord-016990-ot1wi3xi 147 12 trachea trachea NN cord-016990-ot1wi3xi 147 13 , , , cord-016990-ot1wi3xi 147 14 bronchi bronchi NN cord-016990-ot1wi3xi 147 15 , , , cord-016990-ot1wi3xi 147 16 and and CC cord-016990-ot1wi3xi 147 17 bronchioles bronchiole NNS cord-016990-ot1wi3xi 147 18 , , , cord-016990-ot1wi3xi 147 19 in in IN cord-016990-ot1wi3xi 147 20 the the DT cord-016990-ot1wi3xi 147 21 acinar acinar JJ cord-016990-ot1wi3xi 147 22 cells cell NNS cord-016990-ot1wi3xi 147 23 of of IN cord-016990-ot1wi3xi 147 24 bronchial bronchial JJ cord-016990-ot1wi3xi 147 25 glands gland NNS cord-016990-ot1wi3xi 147 26 , , , cord-016990-ot1wi3xi 147 27 and and CC cord-016990-ot1wi3xi 147 28 in in IN cord-016990-ot1wi3xi 147 29 alveolar alveolar JJ cord-016990-ot1wi3xi 147 30 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 147 31 , , , cord-016990-ot1wi3xi 147 32 and and CC cord-016990-ot1wi3xi 147 33 are be VBP cord-016990-ot1wi3xi 147 34 generally generally RB cord-016990-ot1wi3xi 147 35 most most RBS cord-016990-ot1wi3xi 147 36 abundant abundant JJ cord-016990-ot1wi3xi 147 37 at at IN cord-016990-ot1wi3xi 147 38 the the DT cord-016990-ot1wi3xi 147 39 viable viable JJ cord-016990-ot1wi3xi 147 40 edges edge NNS cord-016990-ot1wi3xi 147 41 of of IN cord-016990-ot1wi3xi 147 42 necrotic necrotic JJ cord-016990-ot1wi3xi 147 43 foci foci NN cord-016990-ot1wi3xi 147 44 . . . cord-016990-ot1wi3xi 148 1 By by IN cord-016990-ot1wi3xi 148 2 using use VBG cord-016990-ot1wi3xi 148 3 the the DT cord-016990-ot1wi3xi 148 4 hematoxylin hematoxylin NNP cord-016990-ot1wi3xi 148 5 and and CC cord-016990-ot1wi3xi 148 6 eosin eosin NNP cord-016990-ot1wi3xi 148 7 ( ( -LRB- cord-016990-ot1wi3xi 148 8 H&E H&E NNP cord-016990-ot1wi3xi 148 9 ) ) -RRB- cord-016990-ot1wi3xi 148 10 stain stain NN cord-016990-ot1wi3xi 148 11 , , , cord-016990-ot1wi3xi 148 12 early early JJ cord-016990-ot1wi3xi 148 13 inclusions inclusion NNS cord-016990-ot1wi3xi 148 14 appear appear VBP cord-016990-ot1wi3xi 148 15 as as RB cord-016990-ot1wi3xi 148 16 small small JJ cord-016990-ot1wi3xi 148 17 , , , cord-016990-ot1wi3xi 148 18 dense dense JJ cord-016990-ot1wi3xi 148 19 , , , cord-016990-ot1wi3xi 148 20 amphophilic amphophilic JJ cord-016990-ot1wi3xi 148 21 structures structure NNS cord-016990-ot1wi3xi 148 22 surrounded surround VBN cord-016990-ot1wi3xi 148 23 by by IN cord-016990-ot1wi3xi 148 24 a a DT cord-016990-ot1wi3xi 148 25 cleared clear VBN cord-016990-ot1wi3xi 148 26 zone zone NN cord-016990-ot1wi3xi 148 27 and and CC cord-016990-ot1wi3xi 148 28 peripherally peripherally RB cord-016990-ot1wi3xi 148 29 marginated marginate VBN cord-016990-ot1wi3xi 148 30 chromatin chromatin NNP cord-016990-ot1wi3xi 148 31 , , , cord-016990-ot1wi3xi 148 32 similar similar JJ cord-016990-ot1wi3xi 148 33 to to IN cord-016990-ot1wi3xi 148 34 herpetic herpetic JJ cord-016990-ot1wi3xi 148 35 inclusions inclusion NNS cord-016990-ot1wi3xi 148 36 . . . cord-016990-ot1wi3xi 149 1 As as IN cord-016990-ot1wi3xi 149 2 the the DT cord-016990-ot1wi3xi 149 3 cellular cellular JJ cord-016990-ot1wi3xi 149 4 infection infection NN cord-016990-ot1wi3xi 149 5 progresses progress VBZ cord-016990-ot1wi3xi 149 6 , , , cord-016990-ot1wi3xi 149 7 the the DT cord-016990-ot1wi3xi 149 8 inclusion inclusion NN cord-016990-ot1wi3xi 149 9 becomes become VBZ cord-016990-ot1wi3xi 149 10 larger large JJR cord-016990-ot1wi3xi 149 11 ( ( -LRB- cord-016990-ot1wi3xi 149 12 as as RB cord-016990-ot1wi3xi 149 13 large large JJ cord-016990-ot1wi3xi 149 14 as as IN cord-016990-ot1wi3xi 149 15 14/-lm 14/-lm CD cord-016990-ot1wi3xi 149 16 in in IN cord-016990-ot1wi3xi 149 17 some some DT cord-016990-ot1wi3xi 149 18 cells cell NNS cord-016990-ot1wi3xi 149 19 ) ) -RRB- cord-016990-ot1wi3xi 149 20 and and CC cord-016990-ot1wi3xi 149 21 more more RBR cord-016990-ot1wi3xi 149 22 basophilic basophilic NNP cord-016990-ot1wi3xi 149 23 , , , cord-016990-ot1wi3xi 149 24 and and CC cord-016990-ot1wi3xi 149 25 the the DT cord-016990-ot1wi3xi 149 26 margins margin NNS cord-016990-ot1wi3xi 149 27 of of IN cord-016990-ot1wi3xi 149 28 the the DT cord-016990-ot1wi3xi 149 29 nuclear nuclear JJ cord-016990-ot1wi3xi 149 30 membrane membrane NN cord-016990-ot1wi3xi 149 31 become become VBP cord-016990-ot1wi3xi 149 32 blurred blur VBN cord-016990-ot1wi3xi 149 33 to to TO cord-016990-ot1wi3xi 149 34 form form VB cord-016990-ot1wi3xi 149 35 the the DT cord-016990-ot1wi3xi 149 36 characteristic characteristic JJ cord-016990-ot1wi3xi 149 37 " " `` cord-016990-ot1wi3xi 149 38 smudge smudge NN cord-016990-ot1wi3xi 149 39 cell cell NN cord-016990-ot1wi3xi 149 40 " " '' cord-016990-ot1wi3xi 149 41 ( ( -LRB- cord-016990-ot1wi3xi 149 42 Fig fig NN cord-016990-ot1wi3xi 149 43 . . . cord-016990-ot1wi3xi 150 1 11 11 CD cord-016990-ot1wi3xi 151 1 .2B .2B . cord-016990-ot1wi3xi 152 1 , , , cord-016990-ot1wi3xi 152 2 C).5o,51 C).5o,51 NNP cord-016990-ot1wi3xi 152 3 Tracheal Tracheal NNP cord-016990-ot1wi3xi 152 4 aspirates aspirate NNS cord-016990-ot1wi3xi 152 5 of of IN cord-016990-ot1wi3xi 152 6 patients patient NNS cord-016990-ot1wi3xi 152 7 with with IN cord-016990-ot1wi3xi 152 8 adenovirus adenovirus NN cord-016990-ot1wi3xi 152 9 pneumonia pneumonia NN cord-016990-ot1wi3xi 152 10 may may MD cord-016990-ot1wi3xi 152 11 show show VB cord-016990-ot1wi3xi 152 12 distinctive distinctive JJ cord-016990-ot1wi3xi 152 13 features feature NNS cord-016990-ot1wi3xi 152 14 on on IN cord-016990-ot1wi3xi 152 15 cytologic cytologic JJ cord-016990-ot1wi3xi 152 16 preparations preparation NNS cord-016990-ot1wi3xi 152 17 that that WDT cord-016990-ot1wi3xi 152 18 include include VBP cord-016990-ot1wi3xi 152 19 cells cell NNS cord-016990-ot1wi3xi 152 20 with with IN cord-016990-ot1wi3xi 152 21 fine fine JJ cord-016990-ot1wi3xi 152 22 strands strand NNS cord-016990-ot1wi3xi 152 23 of of IN cord-016990-ot1wi3xi 152 24 chromatin chromatin NN cord-016990-ot1wi3xi 152 25 that that WDT cord-016990-ot1wi3xi 152 26 radiate radiate VBP cord-016990-ot1wi3xi 152 27 from from IN cord-016990-ot1wi3xi 152 28 a a DT cord-016990-ot1wi3xi 152 29 central central JJ cord-016990-ot1wi3xi 152 30 inclusion inclusion NN cord-016990-ot1wi3xi 152 31 to to IN cord-016990-ot1wi3xi 152 32 the the DT cord-016990-ot1wi3xi 152 33 marginated marginate VBN cord-016990-ot1wi3xi 152 34 chromatin chromatin NN cord-016990-ot1wi3xi 152 35 at at IN cord-016990-ot1wi3xi 152 36 the the DT cord-016990-ot1wi3xi 152 37 nuclear nuclear JJ cord-016990-ot1wi3xi 152 38 membrane membrane NN cord-016990-ot1wi3xi 152 39 ( ( -LRB- cord-016990-ot1wi3xi 152 40 " " `` cord-016990-ot1wi3xi 152 41 rosette rosette NN cord-016990-ot1wi3xi 152 42 cells cell NNS cord-016990-ot1wi3xi 152 43 " " '' cord-016990-ot1wi3xi 152 44 ) ) -RRB- cord-016990-ot1wi3xi 152 45 , , , cord-016990-ot1wi3xi 152 46 and and CC cord-016990-ot1wi3xi 152 47 cells cell NNS cord-016990-ot1wi3xi 152 48 with with IN cord-016990-ot1wi3xi 152 49 foamy foamy NN cord-016990-ot1wi3xi 152 50 , , , cord-016990-ot1wi3xi 152 51 " " `` cord-016990-ot1wi3xi 152 52 honeycomb honeycomb NN cord-016990-ot1wi3xi 152 53 " " '' cord-016990-ot1wi3xi 152 54 nuclei nucleus NNS cord-016990-ot1wi3xi 152 55 , , , cord-016990-ot1wi3xi 152 56 as as RB cord-016990-ot1wi3xi 152 57 well well RB cord-016990-ot1wi3xi 152 58 as as IN cord-016990-ot1wi3xi 152 59 typical typical JJ cord-016990-ot1wi3xi 152 60 smudge smudge NN cord-016990-ot1wi3xi 152 61 cells cell NNS cord-016990-ot1wi3xi 152 62 ( ( -LRB- cord-016990-ot1wi3xi 152 63 see see VB cord-016990-ot1wi3xi 152 64 Fig Fig NNP cord-016990-ot1wi3xi 152 65 . . . cord-016990-ot1wi3xi 152 66 _SP cord-016990-ot1wi3xi 153 1 7 7 LS cord-016990-ot1wi3xi 153 2 .45 .45 CD cord-016990-ot1wi3xi 153 3 in in IN cord-016990-ot1wi3xi 153 4 Chapter chapter NN cord-016990-ot1wi3xi 153 5 7 7 CD cord-016990-ot1wi3xi 153 6 ) ) -RRB- cord-016990-ot1wi3xi 153 7 . . . cord-016990-ot1wi3xi 154 1 52 52 CD cord-016990-ot1wi3xi 154 2 Various various JJ cord-016990-ot1wi3xi 154 3 methods method NNS cord-016990-ot1wi3xi 154 4 can can MD cord-016990-ot1wi3xi 154 5 be be VB cord-016990-ot1wi3xi 154 6 used use VBN cord-016990-ot1wi3xi 154 7 to to TO cord-016990-ot1wi3xi 154 8 diagnose diagnose VB cord-016990-ot1wi3xi 154 9 adenovirus adenovirus NN cord-016990-ot1wi3xi 154 10 infections infection NNS cord-016990-ot1wi3xi 154 11 that that WDT cord-016990-ot1wi3xi 154 12 include include VBP cord-016990-ot1wi3xi 154 13 antigen antigen NN cord-016990-ot1wi3xi 154 14 detection detection NN cord-016990-ot1wi3xi 154 15 , , , cord-016990-ot1wi3xi 154 16 cell cell NN cord-016990-ot1wi3xi 154 17 culture culture NN cord-016990-ot1wi3xi 154 18 , , , cord-016990-ot1wi3xi 154 19 electron electron NN cord-016990-ot1wi3xi 154 20 microscopy microscopy NN cord-016990-ot1wi3xi 154 21 , , , cord-016990-ot1wi3xi 154 22 molecular molecular JJ cord-016990-ot1wi3xi 154 23 assays assay NNS cord-016990-ot1wi3xi 154 24 , , , cord-016990-ot1wi3xi 154 25 and and CC cord-016990-ot1wi3xi 154 26 serology serology NN cord-016990-ot1wi3xi 154 27 . . . cord-016990-ot1wi3xi 155 1 Direct direct JJ cord-016990-ot1wi3xi 155 2 detection detection NN cord-016990-ot1wi3xi 155 3 techniques technique NNS cord-016990-ot1wi3xi 155 4 that that WDT cord-016990-ot1wi3xi 155 5 identify identify VBP cord-016990-ot1wi3xi 155 6 the the DT cord-016990-ot1wi3xi 155 7 common common JJ cord-016990-ot1wi3xi 155 8 group group NN cord-016990-ot1wi3xi 155 9 - - HYPH cord-016990-ot1wi3xi 155 10 reactive reactive JJ cord-016990-ot1wi3xi 155 11 hexon hexon NN cord-016990-ot1wi3xi 155 12 antigen antigen NN cord-016990-ot1wi3xi 155 13 in in IN cord-016990-ot1wi3xi 155 14 tissues tissue NNS cord-016990-ot1wi3xi 155 15 or or CC cord-016990-ot1wi3xi 155 16 body body NN cord-016990-ot1wi3xi 155 17 fluids fluid NNS cord-016990-ot1wi3xi 155 18 include include VBP cord-016990-ot1wi3xi 155 19 fluorescence fluorescence NN cord-016990-ot1wi3xi 155 20 antibody antibody NN cord-016990-ot1wi3xi 155 21 assays assay NNS cord-016990-ot1wi3xi 155 22 and and CC cord-016990-ot1wi3xi 155 23 enzyme enzyme NN cord-016990-ot1wi3xi 155 24 immunoassays.53 immunoassays.53 NNP cord-016990-ot1wi3xi 155 25 Immunohistochemistry Immunohistochemistry NNP cord-016990-ot1wi3xi 155 26 staining staining NN cord-016990-ot1wi3xi 155 27 methods method NNS cord-016990-ot1wi3xi 155 28 have have VBP cord-016990-ot1wi3xi 155 29 been be VBN cord-016990-ot1wi3xi 155 30 used use VBN cord-016990-ot1wi3xi 155 31 successfully successfully RB cord-016990-ot1wi3xi 155 32 to to TO cord-016990-ot1wi3xi 155 33 detect detect VB cord-016990-ot1wi3xi 155 34 adenovirus adenovirus NN cord-016990-ot1wi3xi 155 35 - - HYPH cord-016990-ot1wi3xi 155 36 infected infect VBN cord-016990-ot1wi3xi 155 37 cells cell NNS cord-016990-ot1wi3xi 155 38 in in IN cord-016990-ot1wi3xi 155 39 formalin formalin NN cord-016990-ot1wi3xi 155 40 - - HYPH cord-016990-ot1wi3xi 155 41 fixed fix VBN cord-016990-ot1wi3xi 155 42 , , , cord-016990-ot1wi3xi 155 43 paraffinembedded paraffinembedded JJ cord-016990-ot1wi3xi 155 44 tissues tissue NNS cord-016990-ot1wi3xi 155 45 using use VBG cord-016990-ot1wi3xi 155 46 various various JJ cord-016990-ot1wi3xi 155 47 commercially commercially RB cord-016990-ot1wi3xi 155 48 available available JJ cord-016990-ot1wi3xi 155 49 , , , cord-016990-ot1wi3xi 155 50 adenovirus adenovirus NN cord-016990-ot1wi3xi 155 51 group group NN cord-016990-ot1wi3xi 155 52 - - HYPH cord-016990-ot1wi3xi 155 53 specific specific JJ cord-016990-ot1wi3xi 155 54 antibodies antibody NNS cord-016990-ot1wi3xi 155 55 ( ( -LRB- cord-016990-ot1wi3xi 155 56 Fig.11 fig.11 NN cord-016990-ot1wi3xi 155 57 .2E .2E NNP cord-016990-ot1wi3xi 155 58 , , , cord-016990-ot1wi3xi 155 59 F).38,51 F).38,51 NNP cord-016990-ot1wi3xi 155 60 Electron electron NN cord-016990-ot1wi3xi 155 61 microscopy microscopy NN cord-016990-ot1wi3xi 155 62 of of IN cord-016990-ot1wi3xi 155 63 adenovirus adenovirus NN cord-016990-ot1wi3xi 155 64 - - HYPH cord-016990-ot1wi3xi 155 65 infected infect VBN cord-016990-ot1wi3xi 155 66 tissues tissue NNS cord-016990-ot1wi3xi 155 67 reveals reveal VBZ cord-016990-ot1wi3xi 155 68 a a DT cord-016990-ot1wi3xi 155 69 paracrystalline paracrystalline NN cord-016990-ot1wi3xi 155 70 array array NN cord-016990-ot1wi3xi 155 71 of of IN cord-016990-ot1wi3xi 155 72 virions virion NNS cord-016990-ot1wi3xi 155 73 ( ( -LRB- cord-016990-ot1wi3xi 155 74 Fig Fig NNP cord-016990-ot1wi3xi 155 75 . . . cord-016990-ot1wi3xi 155 76 11 11 CD cord-016990-ot1wi3xi 155 77 .2D .2D . cord-016990-ot1wi3xi 155 78 ) ) -RRB- cord-016990-ot1wi3xi 155 79 . . . cord-016990-ot1wi3xi 156 1 54 54 CD cord-016990-ot1wi3xi 156 2 , , , cord-016990-ot1wi3xi 156 3 55 55 CD cord-016990-ot1wi3xi 156 4 Most Most JJS cord-016990-ot1wi3xi 156 5 adenoviruses adenovirus NNS cord-016990-ot1wi3xi 156 6 can can MD cord-016990-ot1wi3xi 156 7 be be VB cord-016990-ot1wi3xi 156 8 isolated isolate VBN cord-016990-ot1wi3xi 156 9 in in IN cord-016990-ot1wi3xi 156 10 cell cell NN cord-016990-ot1wi3xi 156 11 culture culture NN cord-016990-ot1wi3xi 156 12 from from IN cord-016990-ot1wi3xi 156 13 bronchial bronchial JJ cord-016990-ot1wi3xi 156 14 washings washing NNS cord-016990-ot1wi3xi 156 15 , , , cord-016990-ot1wi3xi 156 16 tracheal tracheal JJ cord-016990-ot1wi3xi 156 17 aspirates aspirate NNS cord-016990-ot1wi3xi 156 18 , , , cord-016990-ot1wi3xi 156 19 or or CC cord-016990-ot1wi3xi 156 20 lung lung NN cord-016990-ot1wi3xi 156 21 biopsy biopsy NN cord-016990-ot1wi3xi 156 22 specimens specimen NNS cord-016990-ot1wi3xi 156 23 during during IN cord-016990-ot1wi3xi 156 24 the the DT cord-016990-ot1wi3xi 156 25 early early JJ cord-016990-ot1wi3xi 156 26 stage stage NN cord-016990-ot1wi3xi 156 27 of of IN cord-016990-ot1wi3xi 156 28 the the DT cord-016990-ot1wi3xi 156 29 illness illness NN cord-016990-ot1wi3xi 156 30 and and CC cord-016990-ot1wi3xi 156 31 grow grow VB cord-016990-ot1wi3xi 156 32 well well RB cord-016990-ot1wi3xi 156 33 in in IN cord-016990-ot1wi3xi 156 34 various various JJ cord-016990-ot1wi3xi 156 35 cell cell NN cord-016990-ot1wi3xi 156 36 lines line NNS cord-016990-ot1wi3xi 156 37 , , , cord-016990-ot1wi3xi 156 38 including include VBG cord-016990-ot1wi3xi 156 39 human human JJ cord-016990-ot1wi3xi 156 40 embryonic embryonic JJ cord-016990-ot1wi3xi 156 41 kidney kidney NN cord-016990-ot1wi3xi 156 42 , , , cord-016990-ot1wi3xi 156 43 HeLa HeLa NNP cord-016990-ot1wi3xi 156 44 , , , cord-016990-ot1wi3xi 156 45 and and CC cord-016990-ot1wi3xi 156 46 HEp-2 hep-2 NN cord-016990-ot1wi3xi 156 47 cells cell NNS cord-016990-ot1wi3xi 156 48 . . . cord-016990-ot1wi3xi 157 1 47 47 CD cord-016990-ot1wi3xi 157 2 Cell cell NN cord-016990-ot1wi3xi 157 3 cultures culture NNS cord-016990-ot1wi3xi 157 4 infected infect VBN cord-016990-ot1wi3xi 157 5 with with IN cord-016990-ot1wi3xi 157 6 adenoviruses adenovirus NNS cord-016990-ot1wi3xi 157 7 exhibit exhibit VBP cord-016990-ot1wi3xi 157 8 a a DT cord-016990-ot1wi3xi 157 9 relatively relatively RB cord-016990-ot1wi3xi 157 10 characteristic characteristic JJ cord-016990-ot1wi3xi 157 11 cytopathologic cytopathologic JJ cord-016990-ot1wi3xi 157 12 effect effect NN cord-016990-ot1wi3xi 157 13 , , , cord-016990-ot1wi3xi 157 14 described describe VBN cord-016990-ot1wi3xi 157 15 as as IN cord-016990-ot1wi3xi 157 16 a a DT cord-016990-ot1wi3xi 157 17 " " `` cord-016990-ot1wi3xi 157 18 cluster cluster NN cord-016990-ot1wi3xi 157 19 of of IN cord-016990-ot1wi3xi 157 20 grapes grape NNS cord-016990-ot1wi3xi 157 21 , , , cord-016990-ot1wi3xi 157 22 " " '' cord-016990-ot1wi3xi 157 23 within within IN cord-016990-ot1wi3xi 157 24 3 3 CD cord-016990-ot1wi3xi 157 25 to to TO cord-016990-ot1wi3xi 157 26 5 5 CD cord-016990-ot1wi3xi 157 27 days day NNS cord-016990-ot1wi3xi 157 28 after after IN cord-016990-ot1wi3xi 157 29 inoculation inoculation NN cord-016990-ot1wi3xi 157 30 . . . cord-016990-ot1wi3xi 158 1 Serotyping serotype VBG cord-016990-ot1wi3xi 158 2 of of IN cord-016990-ot1wi3xi 158 3 the the DT cord-016990-ot1wi3xi 158 4 isolate isolate NN cord-016990-ot1wi3xi 158 5 is be VBZ cord-016990-ot1wi3xi 158 6 accomplished accomplish VBN cord-016990-ot1wi3xi 158 7 by by IN cord-016990-ot1wi3xi 158 8 using use VBG cord-016990-ot1wi3xi 158 9 hemagglutination hemagglutination NN cord-016990-ot1wi3xi 158 10 inhibition inhibition NN cord-016990-ot1wi3xi 158 11 and and CC cord-016990-ot1wi3xi 158 12 neutralization neutralization NN cord-016990-ot1wi3xi 158 13 tests test NNS cord-016990-ot1wi3xi 158 14 with with IN cord-016990-ot1wi3xi 158 15 hyperimmune hyperimmune NNP cord-016990-ot1wi3xi 158 16 type type NN cord-016990-ot1wi3xi 158 17 - - HYPH cord-016990-ot1wi3xi 158 18 specific specific JJ cord-016990-ot1wi3xi 158 19 animal animal NN cord-016990-ot1wi3xi 158 20 antisera antisera NN cord-016990-ot1wi3xi 158 21 . . . cord-016990-ot1wi3xi 159 1 56 56 CD cord-016990-ot1wi3xi 159 2 Molecular molecular JJ cord-016990-ot1wi3xi 159 3 assays assay NNS cord-016990-ot1wi3xi 159 4 , , , cord-016990-ot1wi3xi 159 5 particularly particularly RB cord-016990-ot1wi3xi 159 6 gene gene NN cord-016990-ot1wi3xi 159 7 amplification amplification NN cord-016990-ot1wi3xi 159 8 using use VBG cord-016990-ot1wi3xi 159 9 PCR PCR NNP cord-016990-ot1wi3xi 159 10 , , , cord-016990-ot1wi3xi 159 11 and and CC cord-016990-ot1wi3xi 159 12 ISH ish NN cord-016990-ot1wi3xi 159 13 methods method NNS cord-016990-ot1wi3xi 159 14 , , , cord-016990-ot1wi3xi 159 15 have have VBP cord-016990-ot1wi3xi 159 16 been be VBN cord-016990-ot1wi3xi 159 17 developed develop VBN cord-016990-ot1wi3xi 159 18 to to TO cord-016990-ot1wi3xi 159 19 detect detect VB cord-016990-ot1wi3xi 159 20 adenovirus adenovirus NN cord-016990-ot1wi3xi 159 21 nucleic nucleic JJ cord-016990-ot1wi3xi 159 22 acid acid NN cord-016990-ot1wi3xi 159 23 in in IN cord-016990-ot1wi3xi 159 24 respiratory respiratory JJ cord-016990-ot1wi3xi 159 25 secretions secretion NNS cord-016990-ot1wi3xi 159 26 and and CC cord-016990-ot1wi3xi 159 27 in in IN cord-016990-ot1wi3xi 159 28 formalin formalin NN cord-016990-ot1wi3xi 159 29 - - HYPH cord-016990-ot1wi3xi 159 30 fixed fix VBN cord-016990-ot1wi3xi 159 31 , , , cord-016990-ot1wi3xi 159 32 paraffin paraffin NN cord-016990-ot1wi3xi 159 33 - - HYPH cord-016990-ot1wi3xi 159 34 embedded embed VBN cord-016990-ot1wi3xi 159 35 tissues tissue NNS cord-016990-ot1wi3xi 159 36 . . . cord-016990-ot1wi3xi 160 1 51 51 CD cord-016990-ot1wi3xi 160 2 , , , cord-016990-ot1wi3xi 160 3 57,58 57,58 CD cord-016990-ot1wi3xi 160 4 Broad broad JJ cord-016990-ot1wi3xi 160 5 - - HYPH cord-016990-ot1wi3xi 160 6 range range NN cord-016990-ot1wi3xi 160 7 , , , cord-016990-ot1wi3xi 160 8 sensitive sensitive JJ cord-016990-ot1wi3xi 160 9 assays assay NNS cord-016990-ot1wi3xi 160 10 that that WDT cord-016990-ot1wi3xi 160 11 can can MD cord-016990-ot1wi3xi 160 12 detect detect VB cord-016990-ot1wi3xi 160 13 any any DT cord-016990-ot1wi3xi 160 14 adenovirus adenovirus NN cord-016990-ot1wi3xi 160 15 amplify amplify VB cord-016990-ot1wi3xi 160 16 common common JJ cord-016990-ot1wi3xi 160 17 genomic genomic JJ cord-016990-ot1wi3xi 160 18 sequences sequence NNS cord-016990-ot1wi3xi 160 19 ( ( -LRB- cord-016990-ot1wi3xi 160 20 e.g. e.g. RB cord-016990-ot1wi3xi 160 21 , , , cord-016990-ot1wi3xi 160 22 the the DT cord-016990-ot1wi3xi 160 23 hexon hexon NNP cord-016990-ot1wi3xi 160 24 gene gene NN cord-016990-ot1wi3xi 160 25 region region NN cord-016990-ot1wi3xi 160 26 ) ) -RRB- cord-016990-ot1wi3xi 160 27 . . . cord-016990-ot1wi3xi 161 1 Other other JJ cord-016990-ot1wi3xi 161 2 more more RBR cord-016990-ot1wi3xi 161 3 specific specific JJ cord-016990-ot1wi3xi 161 4 assays assay NNS cord-016990-ot1wi3xi 161 5 detect detect VBP cord-016990-ot1wi3xi 161 6 specific specific JJ cord-016990-ot1wi3xi 161 7 adenovirus adenovirus NN cord-016990-ot1wi3xi 161 8 types type NNS cord-016990-ot1wi3xi 161 9 with with IN cord-016990-ot1wi3xi 161 10 unique unique JJ cord-016990-ot1wi3xi 161 11 genomic genomic JJ cord-016990-ot1wi3xi 161 12 sequences sequence NNS cord-016990-ot1wi3xi 161 13 . . . cord-016990-ot1wi3xi 162 1 59 59 CD cord-016990-ot1wi3xi 162 2 Serologic Serologic NNP cord-016990-ot1wi3xi 162 3 assays assay NNS cord-016990-ot1wi3xi 162 4 include include VBP cord-016990-ot1wi3xi 162 5 tests test NNS cord-016990-ot1wi3xi 162 6 for for IN cord-016990-ot1wi3xi 162 7 groupspecific groupspecific NNP cord-016990-ot1wi3xi 162 8 antibodies antibody NNS cord-016990-ot1wi3xi 162 9 ( ( -LRB- cord-016990-ot1wi3xi 162 10 e e NNP cord-016990-ot1wi3xi 162 11 , , , cord-016990-ot1wi3xi 162 12 g g NNP cord-016990-ot1wi3xi 162 13 . . NNP cord-016990-ot1wi3xi 162 14 , , , cord-016990-ot1wi3xi 163 1 complement complement JJ cord-016990-ot1wi3xi 163 2 fixation fixation NN cord-016990-ot1wi3xi 163 3 and and CC cord-016990-ot1wi3xi 163 4 enzyme enzyme NN cord-016990-ot1wi3xi 163 5 immunoassays immunoassays NNP cord-016990-ot1wi3xi 163 6 ) ) -RRB- cord-016990-ot1wi3xi 163 7 , , , cord-016990-ot1wi3xi 163 8 or or CC cord-016990-ot1wi3xi 163 9 type type NN cord-016990-ot1wi3xi 163 10 - - HYPH cord-016990-ot1wi3xi 163 11 specific specific JJ cord-016990-ot1wi3xi 163 12 antibodies antibody NNS cord-016990-ot1wi3xi 163 13 ( ( -LRB- cord-016990-ot1wi3xi 163 14 e.g. e.g. RB cord-016990-ot1wi3xi 163 15 , , , cord-016990-ot1wi3xi 163 16 neutralization neutralization NN cord-016990-ot1wi3xi 163 17 and and CC cord-016990-ot1wi3xi 163 18 hemagglutination hemagglutination NN cord-016990-ot1wi3xi 163 19 - - HYPH cord-016990-ot1wi3xi 163 20 inhibition inhibition NN cord-016990-ot1wi3xi 163 21 assays assay NNS cord-016990-ot1wi3xi 163 22 ) ) -RRB- cord-016990-ot1wi3xi 163 23 . . . cord-016990-ot1wi3xi 164 1 Pitfalls pitfall NNS cord-016990-ot1wi3xi 164 2 associated associate VBN cord-016990-ot1wi3xi 164 3 with with IN cord-016990-ot1wi3xi 164 4 serologic serologic JJ cord-016990-ot1wi3xi 164 5 testing testing NN cord-016990-ot1wi3xi 164 6 for for IN cord-016990-ot1wi3xi 164 7 adenoviruses adenovirus NNS cord-016990-ot1wi3xi 164 8 include include VBP cord-016990-ot1wi3xi 164 9 occasional occasional JJ cord-016990-ot1wi3xi 164 10 rises rise NNS cord-016990-ot1wi3xi 164 11 in in IN cord-016990-ot1wi3xi 164 12 heterotypic heterotypic NNP cord-016990-ot1wi3xi 164 13 antibodies antibody NNS cord-016990-ot1wi3xi 164 14 when when WRB cord-016990-ot1wi3xi 164 15 typespecific typespecific NNP cord-016990-ot1wi3xi 164 16 assays assay NNS cord-016990-ot1wi3xi 164 17 are be VBP cord-016990-ot1wi3xi 164 18 used use VBN cord-016990-ot1wi3xi 164 19 , , , cord-016990-ot1wi3xi 164 20 and and CC cord-016990-ot1wi3xi 164 21 relatively relatively RB cord-016990-ot1wi3xi 164 22 low low JJ cord-016990-ot1wi3xi 164 23 sensitivity sensitivity NN cord-016990-ot1wi3xi 164 24 demonstrated demonstrate VBN cord-016990-ot1wi3xi 164 25 by by IN cord-016990-ot1wi3xi 164 26 complement complement JJ cord-016990-ot1wi3xi 164 27 fixation fixation NN cord-016990-ot1wi3xi 164 28 assays assay NNS cord-016990-ot1wi3xi 164 29 . . . cord-016990-ot1wi3xi 165 1 59 59 CD cord-016990-ot1wi3xi 165 2 Human human JJ cord-016990-ot1wi3xi 165 3 hantaviral hantaviral JJ cord-016990-ot1wi3xi 165 4 diseases disease NNS cord-016990-ot1wi3xi 165 5 are be VBP cord-016990-ot1wi3xi 165 6 caused cause VBN cord-016990-ot1wi3xi 165 7 by by IN cord-016990-ot1wi3xi 165 8 a a DT cord-016990-ot1wi3xi 165 9 group group NN cord-016990-ot1wi3xi 165 10 of of IN cord-016990-ot1wi3xi 165 11 closely closely RB cord-016990-ot1wi3xi 165 12 related relate VBN cord-016990-ot1wi3xi 165 13 , , , cord-016990-ot1wi3xi 165 14 trisegmented trisegmented JJ cord-016990-ot1wi3xi 165 15 , , , cord-016990-ot1wi3xi 165 16 negative negative JJ cord-016990-ot1wi3xi 165 17 - - HYPH cord-016990-ot1wi3xi 165 18 sense sense NN cord-016990-ot1wi3xi 165 19 RNA RNA NNP cord-016990-ot1wi3xi 165 20 viruses virus NNS cord-016990-ot1wi3xi 165 21 of of IN cord-016990-ot1wi3xi 165 22 the the DT cord-016990-ot1wi3xi 165 23 genus genus NN cord-016990-ot1wi3xi 165 24 Hantavirus Hantavirus NNP cord-016990-ot1wi3xi 165 25 , , , cord-016990-ot1wi3xi 165 26 of of IN cord-016990-ot1wi3xi 165 27 the the DT cord-016990-ot1wi3xi 165 28 family family NN cord-016990-ot1wi3xi 165 29 Bunyaviridae Bunyaviridae NNP cord-016990-ot1wi3xi 165 30 . . . cord-016990-ot1wi3xi 166 1 60 60 CD cord-016990-ot1wi3xi 166 2 -62 -62 NN cord-016990-ot1wi3xi 167 1 Members member NNS cord-016990-ot1wi3xi 167 2 of of IN cord-016990-ot1wi3xi 167 3 the the DT cord-016990-ot1wi3xi 167 4 genus genus NN cord-016990-ot1wi3xi 167 5 Hantavirus Hantavirus NNP cord-016990-ot1wi3xi 167 6 have have VBP cord-016990-ot1wi3xi 167 7 similar similar JJ cord-016990-ot1wi3xi 167 8 morphologic morphologic JJ cord-016990-ot1wi3xi 167 9 features feature NNS cord-016990-ot1wi3xi 167 10 . . . cord-016990-ot1wi3xi 168 1 63 63 CD cord-016990-ot1wi3xi 168 2 , , , cord-016990-ot1wi3xi 168 3 64 64 CD cord-016990-ot1wi3xi 168 4 Virus virus NN cord-016990-ot1wi3xi 168 5 particles particle NNS cord-016990-ot1wi3xi 168 6 are be VBP cord-016990-ot1wi3xi 168 7 70 70 CD cord-016990-ot1wi3xi 168 8 to to TO cord-016990-ot1wi3xi 168 9 130 130 CD cord-016990-ot1wi3xi 168 10 nm nm NN cord-016990-ot1wi3xi 168 11 in in IN cord-016990-ot1wi3xi 168 12 diameter diameter NN cord-016990-ot1wi3xi 168 13 and and CC cord-016990-ot1wi3xi 168 14 generally generally RB cord-016990-ot1wi3xi 168 15 appear appear VBP cord-016990-ot1wi3xi 168 16 spherical spherical JJ cord-016990-ot1wi3xi 168 17 to to TO cord-016990-ot1wi3xi 168 18 ovoid ovoid JJ cord-016990-ot1wi3xi 168 19 , , , cord-016990-ot1wi3xi 168 20 although although IN cord-016990-ot1wi3xi 168 21 pleomorphic pleomorphic JJ cord-016990-ot1wi3xi 168 22 forms form NNS cord-016990-ot1wi3xi 168 23 may may MD cord-016990-ot1wi3xi 168 24 be be VB cord-016990-ot1wi3xi 168 25 seen see VBN cord-016990-ot1wi3xi 168 26 . . . cord-016990-ot1wi3xi 169 1 A a DT cord-016990-ot1wi3xi 169 2 lipid lipid NN cord-016990-ot1wi3xi 169 3 envelope envelope NN cord-016990-ot1wi3xi 169 4 containing contain VBG cord-016990-ot1wi3xi 169 5 glycoprotein glycoprotein NN cord-016990-ot1wi3xi 169 6 spikes spike NNS cord-016990-ot1wi3xi 169 7 surrounds surround VBZ cord-016990-ot1wi3xi 169 8 a a DT cord-016990-ot1wi3xi 169 9 core core NN cord-016990-ot1wi3xi 169 10 consisting consist VBG cord-016990-ot1wi3xi 169 11 of of IN cord-016990-ot1wi3xi 169 12 the the DT cord-016990-ot1wi3xi 169 13 genome genome NN cord-016990-ot1wi3xi 169 14 and and CC cord-016990-ot1wi3xi 169 15 its -PRON- PRP$ cord-016990-ot1wi3xi 169 16 associated associate VBN cord-016990-ot1wi3xi 169 17 proteins protein NNS cord-016990-ot1wi3xi 169 18 ( ( -LRB- cord-016990-ot1wi3xi 169 19 nucleocapsids nucleocapsids NNP cord-016990-ot1wi3xi 169 20 ) ) -RRB- cord-016990-ot1wi3xi 170 1 S.R. S.R. NNP cord-016990-ot1wi3xi 170 2 Zaki Zaki NNP cord-016990-ot1wi3xi 170 3 and and CC cord-016990-ot1wi3xi 170 4 CD CD NNP cord-016990-ot1wi3xi 170 5 . . . cord-016990-ot1wi3xi 171 1 Paddock paddock NN cord-016990-ot1wi3xi 171 2 arranged arrange VBD cord-016990-ot1wi3xi 171 3 in in IN cord-016990-ot1wi3xi 171 4 delicate delicate JJ cord-016990-ot1wi3xi 171 5 tangles tangle NNS cord-016990-ot1wi3xi 171 6 of of IN cord-016990-ot1wi3xi 171 7 filaments filament NNS cord-016990-ot1wi3xi 171 8 showing show VBG cord-016990-ot1wi3xi 171 9 occasional occasional JJ cord-016990-ot1wi3xi 171 10 granulation granulation NN cord-016990-ot1wi3xi 171 11 . . . cord-016990-ot1wi3xi 172 1 The the DT cord-016990-ot1wi3xi 172 2 presence presence NN cord-016990-ot1wi3xi 172 3 of of IN cord-016990-ot1wi3xi 172 4 characteristic characteristic JJ cord-016990-ot1wi3xi 172 5 inclusion inclusion NN cord-016990-ot1wi3xi 172 6 bodies body NNS cord-016990-ot1wi3xi 172 7 in in IN cord-016990-ot1wi3xi 172 8 thin thin JJ cord-016990-ot1wi3xi 172 9 section section NN cord-016990-ot1wi3xi 172 10 electron electron NN cord-016990-ot1wi3xi 172 11 microscopy microscopy NN cord-016990-ot1wi3xi 172 12 and and CC cord-016990-ot1wi3xi 172 13 a a DT cord-016990-ot1wi3xi 172 14 unique unique JJ cord-016990-ot1wi3xi 172 15 grid grid NN cord-016990-ot1wi3xi 172 16 - - HYPH cord-016990-ot1wi3xi 172 17 like like JJ cord-016990-ot1wi3xi 172 18 pattern pattern NN cord-016990-ot1wi3xi 172 19 on on IN cord-016990-ot1wi3xi 172 20 negative negative JJ cord-016990-ot1wi3xi 172 21 - - HYPH cord-016990-ot1wi3xi 172 22 stain stain NN cord-016990-ot1wi3xi 172 23 electron electron NN cord-016990-ot1wi3xi 172 24 microscopy microscopy NNS cord-016990-ot1wi3xi 172 25 differentiate differentiate VBP cord-016990-ot1wi3xi 172 26 these these DT cord-016990-ot1wi3xi 172 27 viruses virus NNS cord-016990-ot1wi3xi 172 28 from from IN cord-016990-ot1wi3xi 172 29 other other JJ cord-016990-ot1wi3xi 172 30 members member NNS cord-016990-ot1wi3xi 172 31 of of IN cord-016990-ot1wi3xi 172 32 the the DT cord-016990-ot1wi3xi 172 33 family family NN cord-016990-ot1wi3xi 172 34 Bunyaviridae Bunyaviridae NNP cord-016990-ot1wi3xi 172 35 ( ( -LRB- cord-016990-ot1wi3xi 172 36 Fig Fig NNP cord-016990-ot1wi3xi 172 37 . . . cord-016990-ot1wi3xi 172 38 11.1B 11.1b CD cord-016990-ot1wi3xi 172 39 ) ) -RRB- cord-016990-ot1wi3xi 172 40 . . . cord-016990-ot1wi3xi 173 1 65 65 CD cord-016990-ot1wi3xi 174 1 , , , cord-016990-ot1wi3xi 174 2 66 66 CD cord-016990-ot1wi3xi 175 1 The the DT cord-016990-ot1wi3xi 175 2 severity severity NN cord-016990-ot1wi3xi 175 3 and and CC cord-016990-ot1wi3xi 175 4 disease disease NN cord-016990-ot1wi3xi 175 5 type type NN cord-016990-ot1wi3xi 175 6 largely largely RB cord-016990-ot1wi3xi 175 7 depends depend VBZ cord-016990-ot1wi3xi 175 8 on on IN cord-016990-ot1wi3xi 175 9 the the DT cord-016990-ot1wi3xi 175 10 viral viral JJ cord-016990-ot1wi3xi 175 11 serotype serotype NN cord-016990-ot1wi3xi 175 12 . . . cord-016990-ot1wi3xi 176 1 Two two CD cord-016990-ot1wi3xi 176 2 categories category NNS cord-016990-ot1wi3xi 176 3 of of IN cord-016990-ot1wi3xi 176 4 hantavirus hantavirus NN cord-016990-ot1wi3xi 176 5 - - HYPH cord-016990-ot1wi3xi 176 6 associated associate VBN cord-016990-ot1wi3xi 176 7 illnesses illness NNS cord-016990-ot1wi3xi 176 8 are be VBP cord-016990-ot1wi3xi 176 9 described describe VBN cord-016990-ot1wi3xi 176 10 : : : cord-016990-ot1wi3xi 176 11 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 176 12 fever fever NN cord-016990-ot1wi3xi 176 13 with with IN cord-016990-ot1wi3xi 176 14 renal renal JJ cord-016990-ot1wi3xi 176 15 syndrome syndrome NN cord-016990-ot1wi3xi 176 16 ( ( -LRB- cord-016990-ot1wi3xi 176 17 HFRS HFRS NNP cord-016990-ot1wi3xi 176 18 ) ) -RRB- cord-016990-ot1wi3xi 176 19 for for IN cord-016990-ot1wi3xi 176 20 disease disease NN cord-016990-ot1wi3xi 176 21 in in IN cord-016990-ot1wi3xi 176 22 which which WDT cord-016990-ot1wi3xi 176 23 the the DT cord-016990-ot1wi3xi 176 24 kidneys kidney NNS cord-016990-ot1wi3xi 176 25 are be VBP cord-016990-ot1wi3xi 176 26 primarily primarily RB cord-016990-ot1wi3xi 176 27 involved involve VBN cord-016990-ot1wi3xi 176 28 , , , cord-016990-ot1wi3xi 176 29 and and CC cord-016990-ot1wi3xi 176 30 hantavirus hantavirus NN cord-016990-ot1wi3xi 176 31 pulmonary pulmonary JJ cord-016990-ot1wi3xi 176 32 syndrome syndrome NN cord-016990-ot1wi3xi 176 33 ( ( -LRB- cord-016990-ot1wi3xi 176 34 HPS HPS NNP cord-016990-ot1wi3xi 176 35 ) ) -RRB- cord-016990-ot1wi3xi 176 36 for for IN cord-016990-ot1wi3xi 176 37 disease disease NN cord-016990-ot1wi3xi 176 38 in in IN cord-016990-ot1wi3xi 176 39 which which WDT cord-016990-ot1wi3xi 176 40 the the DT cord-016990-ot1wi3xi 176 41 lungs lung NNS cord-016990-ot1wi3xi 176 42 are be VBP cord-016990-ot1wi3xi 176 43 primarily primarily RB cord-016990-ot1wi3xi 176 44 involved involve VBN cord-016990-ot1wi3xi 176 45 . . . cord-016990-ot1wi3xi 177 1 67 67 CD cord-016990-ot1wi3xi 177 2 -69 -69 NN cord-016990-ot1wi3xi 178 1 The the DT cord-016990-ot1wi3xi 178 2 isolation isolation NN cord-016990-ot1wi3xi 178 3 of of IN cord-016990-ot1wi3xi 178 4 the the DT cord-016990-ot1wi3xi 178 5 first first JJ cord-016990-ot1wi3xi 178 6 recognized recognize VBN cord-016990-ot1wi3xi 178 7 hantavirus hantavirus NN cord-016990-ot1wi3xi 178 8 ( ( -LRB- cord-016990-ot1wi3xi 178 9 Hantaan Hantaan NNP cord-016990-ot1wi3xi 178 10 virus virus NN cord-016990-ot1wi3xi 178 11 , , , cord-016990-ot1wi3xi 178 12 named name VBN cord-016990-ot1wi3xi 178 13 for for IN cord-016990-ot1wi3xi 178 14 the the DT cord-016990-ot1wi3xi 178 15 river river NN cord-016990-ot1wi3xi 178 16 in in IN cord-016990-ot1wi3xi 178 17 South South NNP cord-016990-ot1wi3xi 178 18 Korea Korea NNP cord-016990-ot1wi3xi 178 19 ) ) -RRB- cord-016990-ot1wi3xi 178 20 , , , cord-016990-ot1wi3xi 178 21 and and CC cord-016990-ot1wi3xi 178 22 its -PRON- PRP$ cord-016990-ot1wi3xi 178 23 subsequent subsequent JJ cord-016990-ot1wi3xi 178 24 identification identification NN cord-016990-ot1wi3xi 178 25 as as IN cord-016990-ot1wi3xi 178 26 the the DT cord-016990-ot1wi3xi 178 27 causative causative JJ cord-016990-ot1wi3xi 178 28 agent agent NN cord-016990-ot1wi3xi 178 29 of of IN cord-016990-ot1wi3xi 178 30 HFRS HFRS NNP cord-016990-ot1wi3xi 178 31 was be VBD cord-016990-ot1wi3xi 178 32 reported report VBN cord-016990-ot1wi3xi 178 33 in in IN cord-016990-ot1wi3xi 178 34 1978 1978 CD cord-016990-ot1wi3xi 178 35 . . . cord-016990-ot1wi3xi 179 1 70 70 CD cord-016990-ot1wi3xi 180 1 In in IN cord-016990-ot1wi3xi 180 2 1993 1993 CD cord-016990-ot1wi3xi 180 3 , , , cord-016990-ot1wi3xi 180 4 the the DT cord-016990-ot1wi3xi 180 5 deaths death NNS cord-016990-ot1wi3xi 180 6 of of IN cord-016990-ot1wi3xi 180 7 several several JJ cord-016990-ot1wi3xi 180 8 previously previously RB cord-016990-ot1wi3xi 180 9 healthy healthy JJ cord-016990-ot1wi3xi 180 10 individuals individual NNS cord-016990-ot1wi3xi 180 11 due due JJ cord-016990-ot1wi3xi 180 12 to to IN cord-016990-ot1wi3xi 180 13 a a DT cord-016990-ot1wi3xi 180 14 rapidly rapidly RB cord-016990-ot1wi3xi 180 15 progressive progressive JJ cord-016990-ot1wi3xi 180 16 respiratory respiratory JJ cord-016990-ot1wi3xi 180 17 disease disease NN cord-016990-ot1wi3xi 180 18 in in IN cord-016990-ot1wi3xi 180 19 the the DT cord-016990-ot1wi3xi 180 20 southwestern southwestern JJ cord-016990-ot1wi3xi 180 21 United United NNP cord-016990-ot1wi3xi 180 22 States States NNP cord-016990-ot1wi3xi 180 23 were be VBD cord-016990-ot1wi3xi 180 24 etiologically etiologically RB cord-016990-ot1wi3xi 180 25 linked link VBN cord-016990-ot1wi3xi 180 26 to to IN cord-016990-ot1wi3xi 180 27 a a DT cord-016990-ot1wi3xi 180 28 previously previously RB cord-016990-ot1wi3xi 180 29 unrecognized unrecognized JJ cord-016990-ot1wi3xi 180 30 hantavirus hantavirus NN cord-016990-ot1wi3xi 180 31 . . . cord-016990-ot1wi3xi 181 1 Clinically clinically RB cord-016990-ot1wi3xi 181 2 , , , cord-016990-ot1wi3xi 181 3 the the DT cord-016990-ot1wi3xi 181 4 disease disease NN cord-016990-ot1wi3xi 181 5 differs differ VBZ cord-016990-ot1wi3xi 181 6 from from IN cord-016990-ot1wi3xi 181 7 HFRS HFRS NNP cord-016990-ot1wi3xi 181 8 in in IN cord-016990-ot1wi3xi 181 9 its -PRON- PRP$ cord-016990-ot1wi3xi 181 10 pronounced pronounced JJ cord-016990-ot1wi3xi 181 11 pulmonary pulmonary JJ cord-016990-ot1wi3xi 181 12 involvement involvement NN cord-016990-ot1wi3xi 181 13 and and CC cord-016990-ot1wi3xi 181 14 higher high JJR cord-016990-ot1wi3xi 181 15 mortality mortality NN cord-016990-ot1wi3xi 181 16 rates rate NNS cord-016990-ot1wi3xi 181 17 and and CC cord-016990-ot1wi3xi 181 18 is be VBZ cord-016990-ot1wi3xi 181 19 known know VBN cord-016990-ot1wi3xi 181 20 as as IN cord-016990-ot1wi3xi 181 21 HPS HPS NNP cord-016990-ot1wi3xi 181 22 . . . cord-016990-ot1wi3xi 182 1 23.69,71.72 23.69,71.72 LS cord-016990-ot1wi3xi 182 2 Hantavirus Hantavirus NNP cord-016990-ot1wi3xi 182 3 - - HYPH cord-016990-ot1wi3xi 182 4 associated associate VBN cord-016990-ot1wi3xi 182 5 diseases disease NNS cord-016990-ot1wi3xi 182 6 primarily primarily RB cord-016990-ot1wi3xi 182 7 affect affect VBP cord-016990-ot1wi3xi 182 8 blood blood NN cord-016990-ot1wi3xi 182 9 vessels vessel NNS cord-016990-ot1wi3xi 182 10 and and CC cord-016990-ot1wi3xi 182 11 result result VB cord-016990-ot1wi3xi 182 12 in in IN cord-016990-ot1wi3xi 182 13 different different JJ cord-016990-ot1wi3xi 182 14 degrees degree NNS cord-016990-ot1wi3xi 182 15 of of IN cord-016990-ot1wi3xi 182 16 generalized generalized JJ cord-016990-ot1wi3xi 182 17 capillary capillary JJ cord-016990-ot1wi3xi 182 18 dilatation dilatation NN cord-016990-ot1wi3xi 182 19 and and CC cord-016990-ot1wi3xi 182 20 edema edema NN cord-016990-ot1wi3xi 182 21 . . . cord-016990-ot1wi3xi 183 1 73 73 CD cord-016990-ot1wi3xi 184 1 In in IN cord-016990-ot1wi3xi 184 2 contrast contrast NN cord-016990-ot1wi3xi 184 3 to to IN cord-016990-ot1wi3xi 184 4 severe severe JJ cord-016990-ot1wi3xi 184 5 HFRS HFRS NNP cord-016990-ot1wi3xi 184 6 where where WRB cord-016990-ot1wi3xi 184 7 abundant abundant JJ cord-016990-ot1wi3xi 184 8 protein protein NN cord-016990-ot1wi3xi 184 9 - - HYPH cord-016990-ot1wi3xi 184 10 rich rich JJ cord-016990-ot1wi3xi 184 11 , , , cord-016990-ot1wi3xi 184 12 gelatinous gelatinous JJ cord-016990-ot1wi3xi 184 13 retroperitoneal retroperitoneal JJ cord-016990-ot1wi3xi 184 14 edema edema NN cord-016990-ot1wi3xi 184 15 fluid fluid NN cord-016990-ot1wi3xi 184 16 is be VBZ cord-016990-ot1wi3xi 184 17 found find VBN cord-016990-ot1wi3xi 184 18 , , , cord-016990-ot1wi3xi 184 19 all all DT cord-016990-ot1wi3xi 184 20 HPS hps NN cord-016990-ot1wi3xi 184 21 patients patient NNS cord-016990-ot1wi3xi 184 22 have have VBP cord-016990-ot1wi3xi 184 23 large large JJ cord-016990-ot1wi3xi 184 24 bilateral bilateral JJ cord-016990-ot1wi3xi 184 25 pleural pleural JJ cord-016990-ot1wi3xi 184 26 effusions effusion NNS cord-016990-ot1wi3xi 184 27 and and CC cord-016990-ot1wi3xi 184 28 heavy heavy JJ cord-016990-ot1wi3xi 184 29 edematous edematous JJ cord-016990-ot1wi3xi 184 30 lungs lung NNS cord-016990-ot1wi3xi 184 31 . . . cord-016990-ot1wi3xi 185 1 7 7 CD cord-016990-ot1wi3xi 186 1 In in IN cord-016990-ot1wi3xi 186 2 fatal fatal JJ cord-016990-ot1wi3xi 186 3 Far far JJ cord-016990-ot1wi3xi 186 4 Eastern Eastern NNP cord-016990-ot1wi3xi 186 5 HFRS HFRS NNP cord-016990-ot1wi3xi 186 6 , , , cord-016990-ot1wi3xi 186 7 a a DT cord-016990-ot1wi3xi 186 8 distinctive distinctive JJ cord-016990-ot1wi3xi 186 9 triad triad NN cord-016990-ot1wi3xi 186 10 of of IN cord-016990-ot1wi3xi 186 11 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 186 12 necrosis necrosis NN cord-016990-ot1wi3xi 186 13 can can MD cord-016990-ot1wi3xi 186 14 be be VB cord-016990-ot1wi3xi 186 15 seen see VBN cord-016990-ot1wi3xi 186 16 in in IN cord-016990-ot1wi3xi 186 17 the the DT cord-016990-ot1wi3xi 186 18 renal renal JJ cord-016990-ot1wi3xi 186 19 medullary medullary JJ cord-016990-ot1wi3xi 186 20 junctional junctional JJ cord-016990-ot1wi3xi 186 21 zone zone NN cord-016990-ot1wi3xi 186 22 , , , cord-016990-ot1wi3xi 186 23 cardiac cardiac NNP cord-016990-ot1wi3xi 186 24 right right NNP cord-016990-ot1wi3xi 186 25 atrium atrium NN cord-016990-ot1wi3xi 186 26 , , , cord-016990-ot1wi3xi 186 27 and and CC cord-016990-ot1wi3xi 186 28 anterior anterior JJ cord-016990-ot1wi3xi 186 29 pituitary pituitary NN cord-016990-ot1wi3xi 186 30 . . . cord-016990-ot1wi3xi 187 1 75 75 CD cord-016990-ot1wi3xi 187 2 , , , cord-016990-ot1wi3xi 187 3 78 78 CD cord-016990-ot1wi3xi 188 1 However however RB cord-016990-ot1wi3xi 188 2 , , , cord-016990-ot1wi3xi 188 3 in in IN cord-016990-ot1wi3xi 188 4 patients patient NNS cord-016990-ot1wi3xi 188 5 with with IN cord-016990-ot1wi3xi 188 6 HPS hps NN cord-016990-ot1wi3xi 188 7 , , , cord-016990-ot1wi3xi 188 8 hemorrhages hemorrhage NNS cord-016990-ot1wi3xi 188 9 are be VBP cord-016990-ot1wi3xi 188 10 rare rare JJ cord-016990-ot1wi3xi 188 11 , , , cord-016990-ot1wi3xi 188 12 and and CC cord-016990-ot1wi3xi 188 13 ischemic ischemic JJ cord-016990-ot1wi3xi 188 14 necrotic necrotic JJ cord-016990-ot1wi3xi 188 15 lesions lesion NNS cord-016990-ot1wi3xi 188 16 , , , cord-016990-ot1wi3xi 188 17 except except IN cord-016990-ot1wi3xi 188 18 those those DT cord-016990-ot1wi3xi 188 19 attributed attribute VBN cord-016990-ot1wi3xi 188 20 to to IN cord-016990-ot1wi3xi 188 21 shock shock NN cord-016990-ot1wi3xi 188 22 , , , cord-016990-ot1wi3xi 188 23 are be VBP cord-016990-ot1wi3xi 188 24 not not RB cord-016990-ot1wi3xi 188 25 seen see VBN cord-016990-ot1wi3xi 188 26 . . . cord-016990-ot1wi3xi 189 1 72 72 CD cord-016990-ot1wi3xi 189 2 , , , cord-016990-ot1wi3xi 189 3 74 74 CD cord-016990-ot1wi3xi 189 4 Histologically Histologically NNP cord-016990-ot1wi3xi 189 5 , , , cord-016990-ot1wi3xi 189 6 morphologic morphologic JJ cord-016990-ot1wi3xi 189 7 changes change NNS cord-016990-ot1wi3xi 189 8 of of IN cord-016990-ot1wi3xi 189 9 the the DT cord-016990-ot1wi3xi 189 10 endothelium endothelium NN cord-016990-ot1wi3xi 189 11 are be VBP cord-016990-ot1wi3xi 189 12 uncommon uncommon JJ cord-016990-ot1wi3xi 189 13 but but CC cord-016990-ot1wi3xi 189 14 , , , cord-016990-ot1wi3xi 189 15 when when WRB cord-016990-ot1wi3xi 189 16 seen see VBN cord-016990-ot1wi3xi 189 17 , , , cord-016990-ot1wi3xi 189 18 consist consist VBP cord-016990-ot1wi3xi 189 19 of of IN cord-016990-ot1wi3xi 189 20 prominent prominent JJ cord-016990-ot1wi3xi 189 21 and and CC cord-016990-ot1wi3xi 189 22 swollen swollen JJ cord-016990-ot1wi3xi 189 23 endothelial endothelial JJ cord-016990-ot1wi3xi 189 24 cells cell NNS cord-016990-ot1wi3xi 189 25 . . . cord-016990-ot1wi3xi 190 1 Vascular vascular JJ cord-016990-ot1wi3xi 190 2 thrombi thrombi NN cord-016990-ot1wi3xi 190 3 and and CC cord-016990-ot1wi3xi 190 4 endothelial endothelial JJ cord-016990-ot1wi3xi 190 5 cell cell NN cord-016990-ot1wi3xi 190 6 necrosis necrosis NN cord-016990-ot1wi3xi 190 7 are be VBP cord-016990-ot1wi3xi 190 8 rare rare JJ cord-016990-ot1wi3xi 190 9 . . . cord-016990-ot1wi3xi 191 1 In in IN cord-016990-ot1wi3xi 191 2 HFRS HFRS NNP cord-016990-ot1wi3xi 191 3 , , , cord-016990-ot1wi3xi 191 4 the the DT cord-016990-ot1wi3xi 191 5 most most RBS cord-016990-ot1wi3xi 191 6 severe severe JJ cord-016990-ot1wi3xi 191 7 and and CC cord-016990-ot1wi3xi 191 8 characteristic characteristic JJ cord-016990-ot1wi3xi 191 9 microscopic microscopic JJ cord-016990-ot1wi3xi 191 10 lesions lesion NNS cord-016990-ot1wi3xi 191 11 involve involve VBP cord-016990-ot1wi3xi 191 12 the the DT cord-016990-ot1wi3xi 191 13 kidney kidney NN cord-016990-ot1wi3xi 191 14 ; ; : cord-016990-ot1wi3xi 191 15 however however RB cord-016990-ot1wi3xi 191 16 , , , cord-016990-ot1wi3xi 191 17 an an DT cord-016990-ot1wi3xi 191 18 interstitial interstitial JJ cord-016990-ot1wi3xi 191 19 pneumonitis pneumonitis NN cord-016990-ot1wi3xi 191 20 can can MD cord-016990-ot1wi3xi 191 21 also also RB cord-016990-ot1wi3xi 191 22 be be VB cord-016990-ot1wi3xi 191 23 seen see VBN cord-016990-ot1wi3xi 191 24 in in IN cord-016990-ot1wi3xi 191 25 some some DT cord-016990-ot1wi3xi 191 26 fatal fatal JJ cord-016990-ot1wi3xi 191 27 cases case NNS cord-016990-ot1wi3xi 191 28 . . . cord-016990-ot1wi3xi 192 1 In in IN cord-016990-ot1wi3xi 192 2 contrast contrast NN cord-016990-ot1wi3xi 192 3 , , , cord-016990-ot1wi3xi 192 4 the the DT cord-016990-ot1wi3xi 192 5 microscopic microscopic JJ cord-016990-ot1wi3xi 192 6 changes change NNS cord-016990-ot1wi3xi 192 7 of of IN cord-016990-ot1wi3xi 192 8 North North NNP cord-016990-ot1wi3xi 192 9 and and CC cord-016990-ot1wi3xi 192 10 South south JJ cord-016990-ot1wi3xi 192 11 American american JJ cord-016990-ot1wi3xi 192 12 HPS HPS NNP cord-016990-ot1wi3xi 192 13 are be VBP cord-016990-ot1wi3xi 192 14 principally principally RB cord-016990-ot1wi3xi 192 15 seen see VBN cord-016990-ot1wi3xi 192 16 in in IN cord-016990-ot1wi3xi 192 17 the the DT cord-016990-ot1wi3xi 192 18 lung lung NN cord-016990-ot1wi3xi 192 19 and and CC cord-016990-ot1wi3xi 192 20 spleen spleen NNS cord-016990-ot1wi3xi 192 21 . . . cord-016990-ot1wi3xi 193 1 72 72 CD cord-016990-ot1wi3xi 193 2 , , , cord-016990-ot1wi3xi 193 3 74 74 CD cord-016990-ot1wi3xi 194 1 The the DT cord-016990-ot1wi3xi 194 2 lungs lung NNS cord-016990-ot1wi3xi 194 3 show show VBP cord-016990-ot1wi3xi 194 4 a a DT cord-016990-ot1wi3xi 194 5 mild mild JJ cord-016990-ot1wi3xi 194 6 to to TO cord-016990-ot1wi3xi 194 7 moderate moderate JJ cord-016990-ot1wi3xi 194 8 interstitial interstitial JJ cord-016990-ot1wi3xi 194 9 pneumonitis pneumonitis NN cord-016990-ot1wi3xi 194 10 characterized characterize VBN cord-016990-ot1wi3xi 194 11 by by IN cord-016990-ot1wi3xi 194 12 variable variable JJ cord-016990-ot1wi3xi 194 13 degrees degree NNS cord-016990-ot1wi3xi 194 14 of of IN cord-016990-ot1wi3xi 194 15 edema edema NN cord-016990-ot1wi3xi 194 16 and and CC cord-016990-ot1wi3xi 194 17 an an DT cord-016990-ot1wi3xi 194 18 interstitial interstitial JJ cord-016990-ot1wi3xi 194 19 mononuclear mononuclear JJ cord-016990-ot1wi3xi 194 20 cell cell NN cord-016990-ot1wi3xi 194 21 infiltrate infiltrate NN cord-016990-ot1wi3xi 194 22 comprised comprise VBN cord-016990-ot1wi3xi 194 23 of of IN cord-016990-ot1wi3xi 194 24 a a DT cord-016990-ot1wi3xi 194 25 mixture mixture NN cord-016990-ot1wi3xi 194 26 of of IN cord-016990-ot1wi3xi 194 27 small small JJ cord-016990-ot1wi3xi 194 28 and and CC cord-016990-ot1wi3xi 194 29 enlarged enlarged JJ cord-016990-ot1wi3xi 194 30 mononuclear mononuclear JJ cord-016990-ot1wi3xi 194 31 cells cell NNS cord-016990-ot1wi3xi 194 32 with with IN cord-016990-ot1wi3xi 194 33 the the DT cord-016990-ot1wi3xi 194 34 appearance appearance NN cord-016990-ot1wi3xi 194 35 of of IN cord-016990-ot1wi3xi 194 36 immunoblasts immunoblast NNS cord-016990-ot1wi3xi 194 37 ( ( -LRB- cord-016990-ot1wi3xi 194 38 Fig.11 fig.11 NN cord-016990-ot1wi3xi 194 39 .3A .3A . cord-016990-ot1wi3xi 194 40 ) ) -RRB- cord-016990-ot1wi3xi 194 41 . . . cord-016990-ot1wi3xi 195 1 Focal focal JJ cord-016990-ot1wi3xi 195 2 hyaline hyaline JJ cord-016990-ot1wi3xi 195 3 membranes membrane NNS cord-016990-ot1wi3xi 195 4 composed compose VBN cord-016990-ot1wi3xi 195 5 of of IN cord-016990-ot1wi3xi 195 6 condensed condense VBN cord-016990-ot1wi3xi 195 7 proteinaceous proteinaceous JJ cord-016990-ot1wi3xi 195 8 intraalveolar intraalveolar NN cord-016990-ot1wi3xi 195 9 edema edema NN cord-016990-ot1wi3xi 195 10 fluid fluid NN cord-016990-ot1wi3xi 195 11 , , , cord-016990-ot1wi3xi 195 12 fibrin fibrin NN cord-016990-ot1wi3xi 195 13 , , , cord-016990-ot1wi3xi 195 14 and and CC cord-016990-ot1wi3xi 195 15 variable variable JJ cord-016990-ot1wi3xi 195 16 numbers number NNS cord-016990-ot1wi3xi 195 17 of of IN cord-016990-ot1wi3xi 195 18 inflammatory inflammatory JJ cord-016990-ot1wi3xi 195 19 cells cell NNS cord-016990-ot1wi3xi 195 20 are be VBP cord-016990-ot1wi3xi 195 21 observed observe VBN cord-016990-ot1wi3xi 195 22 ( ( -LRB- cord-016990-ot1wi3xi 195 23 Fig Fig NNP cord-016990-ot1wi3xi 195 24 . . . cord-016990-ot1wi3xi 195 25 11 11 CD cord-016990-ot1wi3xi 195 26 .3B .3b CD cord-016990-ot1wi3xi 195 27 ) ) -RRB- cord-016990-ot1wi3xi 195 28 . . . cord-016990-ot1wi3xi 196 1 Typically typically RB cord-016990-ot1wi3xi 196 2 , , , cord-016990-ot1wi3xi 196 3 neutrophils neutrophil NNS cord-016990-ot1wi3xi 196 4 are be VBP cord-016990-ot1wi3xi 196 5 scanty scanty JJ cord-016990-ot1wi3xi 196 6 and and CC cord-016990-ot1wi3xi 196 7 the the DT cord-016990-ot1wi3xi 196 8 alveolar alveolar NN cord-016990-ot1wi3xi 196 9 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 196 10 are be VBP cord-016990-ot1wi3xi 196 11 intact intact JJ cord-016990-ot1wi3xi 196 12 with with IN cord-016990-ot1wi3xi 196 13 no no DT cord-016990-ot1wi3xi 196 14 evidence evidence NN cord-016990-ot1wi3xi 196 15 of of IN cord-016990-ot1wi3xi 196 16 cellular cellular JJ cord-016990-ot1wi3xi 196 17 debris debris NN cord-016990-ot1wi3xi 196 18 , , , cord-016990-ot1wi3xi 196 19 nuclear nuclear JJ cord-016990-ot1wi3xi 196 20 fragmentation fragmentation NN cord-016990-ot1wi3xi 196 21 , , , cord-016990-ot1wi3xi 196 22 or or CC cord-016990-ot1wi3xi 196 23 hyperplasia hyperplasia NN cord-016990-ot1wi3xi 196 24 . . . cord-016990-ot1wi3xi 197 1 In in IN cord-016990-ot1wi3xi 197 2 fatal fatal JJ cord-016990-ot1wi3xi 197 3 cases case NNS cord-016990-ot1wi3xi 197 4 , , , cord-016990-ot1wi3xi 197 5 with with IN cord-016990-ot1wi3xi 197 6 a a DT cord-016990-ot1wi3xi 197 7 prolonged prolong VBN cord-016990-ot1wi3xi 197 8 survival survival NN cord-016990-ot1wi3xi 197 9 interval interval NN cord-016990-ot1wi3xi 197 10 , , , cord-016990-ot1wi3xi 197 11 tissues tissue NNS cord-016990-ot1wi3xi 197 12 show show VBP cord-016990-ot1wi3xi 197 13 features feature VBZ cord-016990-ot1wi3xi 197 14 more more RBR cord-016990-ot1wi3xi 197 15 characteristic characteristic JJ cord-016990-ot1wi3xi 197 16 of of IN cord-016990-ot1wi3xi 197 17 the the DT cord-016990-ot1wi3xi 197 18 exudative exudative JJ cord-016990-ot1wi3xi 197 19 and and CC cord-016990-ot1wi3xi 197 20 proliferative proliferative JJ cord-016990-ot1wi3xi 197 21 stages stage NNS cord-016990-ot1wi3xi 197 22 of of IN cord-016990-ot1wi3xi 197 23 diffuse diffuse JJ cord-016990-ot1wi3xi 197 24 alveolar alveolar JJ cord-016990-ot1wi3xi 197 25 damage damage NN cord-016990-ot1wi3xi 197 26 . . . cord-016990-ot1wi3xi 198 1 Lung lung NN cord-016990-ot1wi3xi 198 2 biopsies biopsy NNS cord-016990-ot1wi3xi 198 3 taken take VBN cord-016990-ot1wi3xi 198 4 from from IN cord-016990-ot1wi3xi 198 5 patients patient NNS cord-016990-ot1wi3xi 198 6 who who WP cord-016990-ot1wi3xi 198 7 survive survive VBP cord-016990-ot1wi3xi 198 8 their -PRON- PRP$ cord-016990-ot1wi3xi 198 9 illness illness NN cord-016990-ot1wi3xi 198 10 appear appear VBP cord-016990-ot1wi3xi 198 11 similar similar JJ cord-016990-ot1wi3xi 198 12 with with IN cord-016990-ot1wi3xi 198 13 proliferated proliferated JJ cord-016990-ot1wi3xi 198 14 reparative reparative JJ cord-016990-ot1wi3xi 198 15 type type NN cord-016990-ot1wi3xi 198 16 II II NNP cord-016990-ot1wi3xi 198 17 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 198 18 , , , cord-016990-ot1wi3xi 198 19 severe severe JJ cord-016990-ot1wi3xi 198 20 edematous edematous JJ cord-016990-ot1wi3xi 198 21 and and CC cord-016990-ot1wi3xi 198 22 fibroblastic fibroblastic JJ cord-016990-ot1wi3xi 198 23 thickening thickening NN cord-016990-ot1wi3xi 198 24 of of IN cord-016990-ot1wi3xi 198 25 the the DT cord-016990-ot1wi3xi 198 26 alveolar alveolar JJ cord-016990-ot1wi3xi 198 27 septa septa NN cord-016990-ot1wi3xi 198 28 , , , cord-016990-ot1wi3xi 198 29 and and CC cord-016990-ot1wi3xi 198 30 severe severe JJ cord-016990-ot1wi3xi 198 31 air air NN cord-016990-ot1wi3xi 198 32 - - HYPH cord-016990-ot1wi3xi 198 33 space space NN cord-016990-ot1wi3xi 198 34 disorganization disorganization NN cord-016990-ot1wi3xi 198 35 with with IN cord-016990-ot1wi3xi 198 36 distorted distorted JJ cord-016990-ot1wi3xi 198 37 lung lung NN cord-016990-ot1wi3xi 198 38 architecture architecture NN cord-016990-ot1wi3xi 198 39 ( ( -LRB- cord-016990-ot1wi3xi 198 40 see see VB cord-016990-ot1wi3xi 198 41 Chapter chapter NN cord-016990-ot1wi3xi 198 42 4 4 CD cord-016990-ot1wi3xi 198 43 ) ) -RRB- cord-016990-ot1wi3xi 198 44 . . . cord-016990-ot1wi3xi 199 1 Other other JJ cord-016990-ot1wi3xi 199 2 characteristic characteristic JJ cord-016990-ot1wi3xi 199 3 microscopic microscopic JJ cord-016990-ot1wi3xi 199 4 findings finding NNS cord-016990-ot1wi3xi 199 5 in in IN cord-016990-ot1wi3xi 199 6 HPS hps NN cord-016990-ot1wi3xi 199 7 cases case NNS cord-016990-ot1wi3xi 199 8 include include VBP cord-016990-ot1wi3xi 199 9 variable variable JJ cord-016990-ot1wi3xi 199 10 numbers number NNS cord-016990-ot1wi3xi 199 11 of of IN cord-016990-ot1wi3xi 199 12 immunoblasts immunoblast NNS cord-016990-ot1wi3xi 199 13 within within IN cord-016990-ot1wi3xi 199 14 the the DT cord-016990-ot1wi3xi 199 15 splenic splenic JJ cord-016990-ot1wi3xi 199 16 red red JJ cord-016990-ot1wi3xi 199 17 pulp pulp NN cord-016990-ot1wi3xi 199 18 and and CC cord-016990-ot1wi3xi 199 19 periarteriolar periarteriolar JJ cord-016990-ot1wi3xi 199 20 white white JJ cord-016990-ot1wi3xi 199 21 pulp pulp NN cord-016990-ot1wi3xi 199 22 , , , cord-016990-ot1wi3xi 199 23 lymph lymph NN cord-016990-ot1wi3xi 199 24 nodal nodal JJ cord-016990-ot1wi3xi 199 25 paracortical paracortical JJ cord-016990-ot1wi3xi 199 26 zones zone NNS cord-016990-ot1wi3xi 199 27 , , , cord-016990-ot1wi3xi 199 28 hepatic hepatic JJ cord-016990-ot1wi3xi 199 29 portal portal JJ cord-016990-ot1wi3xi 199 30 triads triad NNS cord-016990-ot1wi3xi 199 31 , , , cord-016990-ot1wi3xi 199 32 and and CC cord-016990-ot1wi3xi 199 33 peripheral peripheral JJ cord-016990-ot1wi3xi 199 34 blood blood NN cord-016990-ot1wi3xi 199 35 ( ( -LRB- cord-016990-ot1wi3xi 199 36 Fig Fig NNP cord-016990-ot1wi3xi 199 37 . . . cord-016990-ot1wi3xi 199 38 11.3D 11.3d CD cord-016990-ot1wi3xi 199 39 , , , cord-016990-ot1wi3xi 199 40 E E NNP cord-016990-ot1wi3xi 199 41 ) ) -RRB- cord-016990-ot1wi3xi 199 42 . . . cord-016990-ot1wi3xi 200 1 Similarly similarly RB cord-016990-ot1wi3xi 200 2 , , , cord-016990-ot1wi3xi 200 3 in in IN cord-016990-ot1wi3xi 200 4 severe severe JJ cord-016990-ot1wi3xi 200 5 HFRS HFRS NNP cord-016990-ot1wi3xi 200 6 cases case NNS cord-016990-ot1wi3xi 200 7 , , , cord-016990-ot1wi3xi 200 8 large large JJ cord-016990-ot1wi3xi 200 9 mononuclear mononuclear JJ cord-016990-ot1wi3xi 200 10 cells cell NNS cord-016990-ot1wi3xi 200 11 can can MD cord-016990-ot1wi3xi 200 12 be be VB cord-016990-ot1wi3xi 200 13 present present JJ cord-016990-ot1wi3xi 200 14 in in IN cord-016990-ot1wi3xi 200 15 the the DT cord-016990-ot1wi3xi 200 16 spleen spleen NN cord-016990-ot1wi3xi 200 17 , , , cord-016990-ot1wi3xi 200 18 lymph lymph NN cord-016990-ot1wi3xi 200 19 nodes node NNS cord-016990-ot1wi3xi 200 20 , , , cord-016990-ot1wi3xi 200 21 blood blood NN cord-016990-ot1wi3xi 200 22 , , , cord-016990-ot1wi3xi 200 23 and and CC cord-016990-ot1wi3xi 200 24 hepatic hepatic JJ cord-016990-ot1wi3xi 200 25 portal portal JJ cord-016990-ot1wi3xi 200 26 triads triad NNS cord-016990-ot1wi3xi 200 27 . . . cord-016990-ot1wi3xi 201 1 75 75 CD cord-016990-ot1wi3xi 201 2 . . . cord-016990-ot1wi3xi 202 1 76 76 CD cord-016990-ot1wi3xi 203 1 Electron electron NN cord-016990-ot1wi3xi 203 2 microscopic microscopic JJ cord-016990-ot1wi3xi 203 3 studies study NNS cord-016990-ot1wi3xi 203 4 of of IN cord-016990-ot1wi3xi 203 5 HPS hps NN cord-016990-ot1wi3xi 203 6 lung lung NN cord-016990-ot1wi3xi 203 7 tissue tissue NN cord-016990-ot1wi3xi 203 8 demonstrate demonstrate VBP cord-016990-ot1wi3xi 203 9 infection infection NN cord-016990-ot1wi3xi 203 10 of of IN cord-016990-ot1wi3xi 203 11 endothelial endothelial JJ cord-016990-ot1wi3xi 203 12 cells cell NNS cord-016990-ot1wi3xi 203 13 and and CC cord-016990-ot1wi3xi 203 14 macrophages macrophage NNS cord-016990-ot1wi3xi 203 15 . . . cord-016990-ot1wi3xi 204 1 69 69 CD cord-016990-ot1wi3xi 204 2 . . . cord-016990-ot1wi3xi 205 1 72 72 CD cord-016990-ot1wi3xi 206 1 The the DT cord-016990-ot1wi3xi 206 2 virus virus NN cord-016990-ot1wi3xi 206 3 or or CC cord-016990-ot1wi3xi 206 4 virus virus NN cord-016990-ot1wi3xi 206 5 - - HYPH cord-016990-ot1wi3xi 206 6 like like JJ cord-016990-ot1wi3xi 206 7 particles particle NNS cord-016990-ot1wi3xi 206 8 observed observe VBN cord-016990-ot1wi3xi 206 9 are be VBP cord-016990-ot1wi3xi 206 10 infrequent infrequent JJ cord-016990-ot1wi3xi 206 11 and and CC cord-016990-ot1wi3xi 206 12 extremely extremely RB cord-016990-ot1wi3xi 206 13 difficult difficult JJ cord-016990-ot1wi3xi 206 14 to to TO cord-016990-ot1wi3xi 206 15 identify identify VB cord-016990-ot1wi3xi 206 16 in in IN cord-016990-ot1wi3xi 206 17 autopsy autopsy JJ cord-016990-ot1wi3xi 206 18 tissues tissue NNS cord-016990-ot1wi3xi 206 19 because because IN cord-016990-ot1wi3xi 206 20 of of IN cord-016990-ot1wi3xi 206 21 the the DT cord-016990-ot1wi3xi 206 22 considerable considerable JJ cord-016990-ot1wi3xi 206 23 degree degree NN cord-016990-ot1wi3xi 206 24 of of IN cord-016990-ot1wi3xi 206 25 viral viral JJ cord-016990-ot1wi3xi 206 26 pleomorphism pleomorphism NN cord-016990-ot1wi3xi 206 27 and and CC cord-016990-ot1wi3xi 206 28 the the DT cord-016990-ot1wi3xi 206 29 postmortem postmortem JJ cord-016990-ot1wi3xi 206 30 deterioration deterioration NN cord-016990-ot1wi3xi 206 31 of of IN cord-016990-ot1wi3xi 206 32 tissues tissue NNS cord-016990-ot1wi3xi 206 33 . . . cord-016990-ot1wi3xi 207 1 However however RB cord-016990-ot1wi3xi 207 2 , , , cord-016990-ot1wi3xi 207 3 typical typical JJ cord-016990-ot1wi3xi 207 4 hantaviral hantaviral JJ cord-016990-ot1wi3xi 207 5 inclusions inclusion NNS cord-016990-ot1wi3xi 207 6 are be VBP cord-016990-ot1wi3xi 207 7 seen see VBN cord-016990-ot1wi3xi 207 8 more more RBR cord-016990-ot1wi3xi 207 9 frequently frequently RB cord-016990-ot1wi3xi 207 10 and and CC cord-016990-ot1wi3xi 207 11 their -PRON- PRP$ cord-016990-ot1wi3xi 207 12 identity identity NN cord-016990-ot1wi3xi 207 13 can can MD cord-016990-ot1wi3xi 207 14 be be VB cord-016990-ot1wi3xi 207 15 confirmed confirm VBN cord-016990-ot1wi3xi 207 16 by by IN cord-016990-ot1wi3xi 207 17 immunolabeling immunolabele VBG cord-016990-ot1wi3xi 207 18 ( ( -LRB- cord-016990-ot1wi3xi 207 19 Fig fig NN cord-016990-ot1wi3xi 207 20 . . . cord-016990-ot1wi3xi 208 1 11 11 CD cord-016990-ot1wi3xi 208 2 .3F .3F NNP cord-016990-ot1wi3xi 208 3 , , , cord-016990-ot1wi3xi 208 4 G G NNP cord-016990-ot1wi3xi 208 5 ) ) -RRB- cord-016990-ot1wi3xi 208 6 . . . cord-016990-ot1wi3xi 209 1 Similar similar JJ cord-016990-ot1wi3xi 209 2 inclusions inclusion NNS cord-016990-ot1wi3xi 209 3 are be VBP cord-016990-ot1wi3xi 209 4 observed observe VBN cord-016990-ot1wi3xi 209 5 in in IN cord-016990-ot1wi3xi 209 6 epithelial epithelial JJ cord-016990-ot1wi3xi 209 7 cells cell NNS cord-016990-ot1wi3xi 209 8 in in IN cord-016990-ot1wi3xi 209 9 HFRS HFRS NNP cord-016990-ot1wi3xi 209 10 and and CC cord-016990-ot1wi3xi 209 11 are be VBP cord-016990-ot1wi3xi 209 12 considered consider VBN cord-016990-ot1wi3xi 209 13 to to TO cord-016990-ot1wi3xi 209 14 be be VB cord-016990-ot1wi3xi 209 15 ultrastructural ultrastructural JJ cord-016990-ot1wi3xi 209 16 markers marker NNS cord-016990-ot1wi3xi 209 17 of of IN cord-016990-ot1wi3xi 209 18 hantavirus hantavirus NN cord-016990-ot1wi3xi 209 19 - - HYPH cord-016990-ot1wi3xi 209 20 infected infect VBN cord-016990-ot1wi3xi 209 21 cells cell NNS cord-016990-ot1wi3xi 209 22 . . . cord-016990-ot1wi3xi 210 1 63 63 CD cord-016990-ot1wi3xi 210 2 .79.8o .79.8o . cord-016990-ot1wi3xi 211 1 Using use VBG cord-016990-ot1wi3xi 211 2 immunohistochemistry immunohistochemistry NN cord-016990-ot1wi3xi 211 3 , , , cord-016990-ot1wi3xi 211 4 viral viral JJ cord-016990-ot1wi3xi 211 5 antigens antigen NNS cord-016990-ot1wi3xi 211 6 are be VBP cord-016990-ot1wi3xi 211 7 found find VBN cord-016990-ot1wi3xi 211 8 primarily primarily RB cord-016990-ot1wi3xi 211 9 within within IN cord-016990-ot1wi3xi 211 10 capillary capillary JJ cord-016990-ot1wi3xi 211 11 endothelium endothelium NN cord-016990-ot1wi3xi 211 12 throughout throughout IN cord-016990-ot1wi3xi 211 13 various various JJ cord-016990-ot1wi3xi 211 14 tissues tissue NNS cord-016990-ot1wi3xi 211 15 in in IN cord-016990-ot1wi3xi 211 16 both both CC cord-016990-ot1wi3xi 211 17 HPS HPS NNP cord-016990-ot1wi3xi 211 18 and and CC cord-016990-ot1wi3xi 211 19 HFRS HFRS NNP cord-016990-ot1wi3xi 211 20 . . . cord-016990-ot1wi3xi 212 1 In in IN cord-016990-ot1wi3xi 212 2 HPS HPS NNP cord-016990-ot1wi3xi 212 3 , , , cord-016990-ot1wi3xi 212 4 marked marked JJ cord-016990-ot1wi3xi 212 5 accumulations accumulation NNS cord-016990-ot1wi3xi 212 6 of of IN cord-016990-ot1wi3xi 212 7 hantaviral hantaviral JJ cord-016990-ot1wi3xi 212 8 antigens antigen NNS cord-016990-ot1wi3xi 212 9 are be VBP cord-016990-ot1wi3xi 212 10 in in IN cord-016990-ot1wi3xi 212 11 the the DT cord-016990-ot1wi3xi 212 12 pulmonary pulmonary JJ cord-016990-ot1wi3xi 212 13 microvasculature microvasculature NN cord-016990-ot1wi3xi 212 14 and and CC cord-016990-ot1wi3xi 212 15 in in IN cord-016990-ot1wi3xi 212 16 splenic splenic JJ cord-016990-ot1wi3xi 212 17 and and CC cord-016990-ot1wi3xi 212 18 lymph lymph NN cord-016990-ot1wi3xi 212 19 nodal nodal JJ cord-016990-ot1wi3xi 212 20 follicular follicular JJ cord-016990-ot1wi3xi 212 21 dendritic dendritic JJ cord-016990-ot1wi3xi 212 22 cells cell NNS cord-016990-ot1wi3xi 212 23 ( ( -LRB- cord-016990-ot1wi3xi 212 24 Fig Fig NNP cord-016990-ot1wi3xi 212 25 . . . cord-016990-ot1wi3xi 212 26 11 11 CD cord-016990-ot1wi3xi 212 27 .3C).72 .3C).72 . cord-016990-ot1wi3xi 213 1 Despite despite IN cord-016990-ot1wi3xi 213 2 the the DT cord-016990-ot1wi3xi 213 3 extensive extensive JJ cord-016990-ot1wi3xi 213 4 endothelial endothelial JJ cord-016990-ot1wi3xi 213 5 cell cell NN cord-016990-ot1wi3xi 213 6 accumulations accumulation NNS cord-016990-ot1wi3xi 213 7 of of IN cord-016990-ot1wi3xi 213 8 hantaviral hantaviral JJ cord-016990-ot1wi3xi 213 9 antigens antigen NNS cord-016990-ot1wi3xi 213 10 , , , cord-016990-ot1wi3xi 213 11 there there EX cord-016990-ot1wi3xi 213 12 is be VBZ cord-016990-ot1wi3xi 213 13 little little JJ cord-016990-ot1wi3xi 213 14 ultrastructural ultrastructural JJ cord-016990-ot1wi3xi 213 15 evidence evidence NN cord-016990-ot1wi3xi 213 16 of of IN cord-016990-ot1wi3xi 213 17 cytopathic cytopathic JJ cord-016990-ot1wi3xi 213 18 effect effect NN cord-016990-ot1wi3xi 213 19 . . . cord-016990-ot1wi3xi 214 1 Hantavirus Hantavirus NNP cord-016990-ot1wi3xi 214 2 pulmonary pulmonary JJ cord-016990-ot1wi3xi 214 3 syndrome syndrome NN cord-016990-ot1wi3xi 214 4 should should MD cord-016990-ot1wi3xi 214 5 be be VB cord-016990-ot1wi3xi 214 6 suspected suspect VBN cord-016990-ot1wi3xi 214 7 in in IN cord-016990-ot1wi3xi 214 8 cases case NNS cord-016990-ot1wi3xi 214 9 of of IN cord-016990-ot1wi3xi 214 10 adult adult JJ cord-016990-ot1wi3xi 214 11 respiratory respiratory JJ cord-016990-ot1wi3xi 214 12 distress distress NN cord-016990-ot1wi3xi 214 13 syndrome syndrome NN cord-016990-ot1wi3xi 214 14 ( ( -LRB- cord-016990-ot1wi3xi 214 15 ARDS ARDS NNP cord-016990-ot1wi3xi 214 16 ) ) -RRB- cord-016990-ot1wi3xi 214 17 without without IN cord-016990-ot1wi3xi 214 18 a a DT cord-016990-ot1wi3xi 214 19 known know VBN cord-016990-ot1wi3xi 214 20 precipitating precipitating NN cord-016990-ot1wi3xi 214 21 cause cause NN cord-016990-ot1wi3xi 214 22 among among IN cord-016990-ot1wi3xi 214 23 previously previously RB cord-016990-ot1wi3xi 214 24 healthy healthy JJ cord-016990-ot1wi3xi 214 25 individuals individual NNS cord-016990-ot1wi3xi 214 26 . . . cord-016990-ot1wi3xi 215 1 The the DT cord-016990-ot1wi3xi 215 2 level level NN cord-016990-ot1wi3xi 215 3 of of IN cord-016990-ot1wi3xi 215 4 suspicion suspicion NN cord-016990-ot1wi3xi 215 5 should should MD cord-016990-ot1wi3xi 215 6 be be VB cord-016990-ot1wi3xi 215 7 particularly particularly RB cord-016990-ot1wi3xi 215 8 high high JJ cord-016990-ot1wi3xi 215 9 when when WRB cord-016990-ot1wi3xi 215 10 patients patient NNS cord-016990-ot1wi3xi 215 11 have have VBP cord-016990-ot1wi3xi 215 12 a a DT cord-016990-ot1wi3xi 215 13 known know VBN cord-016990-ot1wi3xi 215 14 exposure exposure NN cord-016990-ot1wi3xi 215 15 to to IN cord-016990-ot1wi3xi 215 16 rodents rodent NNS cord-016990-ot1wi3xi 215 17 in in IN cord-016990-ot1wi3xi 215 18 areas area NNS cord-016990-ot1wi3xi 215 19 where where WRB cord-016990-ot1wi3xi 215 20 Peromyscus Peromyscus NNP cord-016990-ot1wi3xi 215 21 maniculatus maniculatus NN cord-016990-ot1wi3xi 215 22 or or CC cord-016990-ot1wi3xi 215 23 other other JJ cord-016990-ot1wi3xi 215 24 reservoirs reservoir NNS cord-016990-ot1wi3xi 215 25 of of IN cord-016990-ot1wi3xi 215 26 hantavirus hantavirus NN cord-016990-ot1wi3xi 215 27 are be VBP cord-016990-ot1wi3xi 215 28 found find VBN cord-016990-ot1wi3xi 215 29 . . . cord-016990-ot1wi3xi 216 1 Physicians physician NNS cord-016990-ot1wi3xi 216 2 need need VBP cord-016990-ot1wi3xi 216 3 to to TO cord-016990-ot1wi3xi 216 4 differentiate differentiate VB cord-016990-ot1wi3xi 216 5 HPS hps NN cord-016990-ot1wi3xi 216 6 from from IN cord-016990-ot1wi3xi 216 7 other other JJ cord-016990-ot1wi3xi 216 8 common common JJ cord-016990-ot1wi3xi 216 9 acute acute JJ cord-016990-ot1wi3xi 216 10 respiratory respiratory JJ cord-016990-ot1wi3xi 216 11 diseases disease NNS cord-016990-ot1wi3xi 216 12 , , , cord-016990-ot1wi3xi 216 13 such such JJ cord-016990-ot1wi3xi 216 14 as as IN cord-016990-ot1wi3xi 216 15 pneumococcal pneumococcal JJ cord-016990-ot1wi3xi 216 16 pneumonia pneumonia NN cord-016990-ot1wi3xi 216 17 , , , cord-016990-ot1wi3xi 216 18 influenza influenza NN cord-016990-ot1wi3xi 216 19 virus virus NN cord-016990-ot1wi3xi 216 20 , , , cord-016990-ot1wi3xi 216 21 and and CC cord-016990-ot1wi3xi 216 22 unexplained unexplained JJ cord-016990-ot1wi3xi 216 23 ARDS ARDS NNP cord-016990-ot1wi3xi 216 24 . . . cord-016990-ot1wi3xi 217 1 The the DT cord-016990-ot1wi3xi 217 2 diagnosis diagnosis NN cord-016990-ot1wi3xi 217 3 of of IN cord-016990-ot1wi3xi 217 4 HPS HPS NNP cord-016990-ot1wi3xi 217 5 , , , cord-016990-ot1wi3xi 217 6 suspected suspect VBN cord-016990-ot1wi3xi 217 7 by by IN cord-016990-ot1wi3xi 217 8 patient patient JJ cord-016990-ot1wi3xi 217 9 history history NN cord-016990-ot1wi3xi 217 10 and and CC cord-016990-ot1wi3xi 217 11 clinical clinical JJ cord-016990-ot1wi3xi 217 12 manifestations manifestation NNS cord-016990-ot1wi3xi 217 13 , , , cord-016990-ot1wi3xi 217 14 can can MD cord-016990-ot1wi3xi 217 15 also also RB cord-016990-ot1wi3xi 217 16 be be VB cord-016990-ot1wi3xi 217 17 supported support VBN cord-016990-ot1wi3xi 217 18 histopathologically histopathologically RB cord-016990-ot1wi3xi 217 19 . . . cord-016990-ot1wi3xi 218 1 Although although IN cord-016990-ot1wi3xi 218 2 there there EX cord-016990-ot1wi3xi 218 3 is be VBZ cord-016990-ot1wi3xi 218 4 no no DT cord-016990-ot1wi3xi 218 5 single single JJ cord-016990-ot1wi3xi 218 6 pathognomonic pathognomonic JJ cord-016990-ot1wi3xi 218 7 lesion lesion NN cord-016990-ot1wi3xi 218 8 that that WDT cord-016990-ot1wi3xi 218 9 would would MD cord-016990-ot1wi3xi 218 10 permit permit VB cord-016990-ot1wi3xi 218 11 certain certain JJ cord-016990-ot1wi3xi 218 12 histopathologic histopathologic JJ cord-016990-ot1wi3xi 218 13 diagnosis diagnosis NN cord-016990-ot1wi3xi 218 14 of of IN cord-016990-ot1wi3xi 218 15 HPS HPS NNP cord-016990-ot1wi3xi 218 16 , , , cord-016990-ot1wi3xi 219 1 the the DT cord-016990-ot1wi3xi 219 2 overall overall JJ cord-016990-ot1wi3xi 219 3 constellation constellation NN cord-016990-ot1wi3xi 219 4 of of IN cord-016990-ot1wi3xi 219 5 histopathologic histopathologic JJ cord-016990-ot1wi3xi 219 6 hematologic hematologic JJ cord-016990-ot1wi3xi 219 7 findings finding NNS cord-016990-ot1wi3xi 219 8 suggests suggest VBZ cord-016990-ot1wi3xi 219 9 the the DT cord-016990-ot1wi3xi 219 10 diagnosis.72.7 diagnosis.72.7 NNP cord-016990-ot1wi3xi 219 11 4 4 CD cord-016990-ot1wi3xi 219 12 Diseases disease NNS cord-016990-ot1wi3xi 219 13 that that WDT cord-016990-ot1wi3xi 219 14 need need VBP cord-016990-ot1wi3xi 219 15 to to TO cord-016990-ot1wi3xi 219 16 be be VB cord-016990-ot1wi3xi 219 17 distinguished distinguish VBN cord-016990-ot1wi3xi 219 18 pathologically pathologically RB cord-016990-ot1wi3xi 219 19 from from IN cord-016990-ot1wi3xi 219 20 HPS hps NN cord-016990-ot1wi3xi 219 21 include include VBP cord-016990-ot1wi3xi 219 22 a a DT cord-016990-ot1wi3xi 219 23 relatively relatively RB cord-016990-ot1wi3xi 219 24 large large JJ cord-016990-ot1wi3xi 219 25 number number NN cord-016990-ot1wi3xi 219 26 of of IN cord-016990-ot1wi3xi 219 27 different different JJ cord-016990-ot1wi3xi 219 28 viral viral JJ cord-016990-ot1wi3xi 219 29 , , , cord-016990-ot1wi3xi 219 30 rickettsial rickettsial JJ cord-016990-ot1wi3xi 219 31 , , , cord-016990-ot1wi3xi 219 32 and and CC cord-016990-ot1wi3xi 219 33 bacterial bacterial JJ cord-016990-ot1wi3xi 219 34 infections infection NNS cord-016990-ot1wi3xi 219 35 , , , cord-016990-ot1wi3xi 219 36 as as RB cord-016990-ot1wi3xi 219 37 well well RB cord-016990-ot1wi3xi 219 38 as as IN cord-016990-ot1wi3xi 219 39 various various JJ cord-016990-ot1wi3xi 219 40 noninfectious noninfectious JJ cord-016990-ot1wi3xi 219 41 disease disease NN cord-016990-ot1wi3xi 219 42 processes process NNS cord-016990-ot1wi3xi 219 43 . . . cord-016990-ot1wi3xi 220 1 Virus virus NN cord-016990-ot1wi3xi 220 2 - - HYPH cord-016990-ot1wi3xi 220 3 specific specific JJ cord-016990-ot1wi3xi 220 4 diagnosis diagnosis NN cord-016990-ot1wi3xi 220 5 and and CC cord-016990-ot1wi3xi 220 6 confirmation confirmation NN cord-016990-ot1wi3xi 220 7 can can MD cord-016990-ot1wi3xi 220 8 be be VB cord-016990-ot1wi3xi 220 9 achieved achieve VBN cord-016990-ot1wi3xi 220 10 through through IN cord-016990-ot1wi3xi 220 11 serology serology NN cord-016990-ot1wi3xi 220 12 , , , cord-016990-ot1wi3xi 220 13 PCR PCR NNP cord-016990-ot1wi3xi 220 14 for for IN cord-016990-ot1wi3xi 220 15 hantavirus hantavirus NN cord-016990-ot1wi3xi 220 16 RNA RNA NNP cord-016990-ot1wi3xi 220 17 , , , cord-016990-ot1wi3xi 220 18 or or CC cord-016990-ot1wi3xi 220 19 IHC IHC NNP cord-016990-ot1wi3xi 220 20 for for IN cord-016990-ot1wi3xi 220 21 hantaviral hantaviral JJ cord-016990-ot1wi3xi 220 22 antigens antigen NNS cord-016990-ot1wi3xi 220 23 . . . cord-016990-ot1wi3xi 221 1 2 2 LS cord-016990-ot1wi3xi 221 2 1,72 1,72 CD cord-016990-ot1wi3xi 221 3 Serologic Serologic NNP cord-016990-ot1wi3xi 221 4 testing testing NN cord-016990-ot1wi3xi 221 5 can can MD cord-016990-ot1wi3xi 221 6 detect detect VB cord-016990-ot1wi3xi 221 7 hantavirus hantavirus NN cord-016990-ot1wi3xi 221 8 - - HYPH cord-016990-ot1wi3xi 221 9 specific specific JJ cord-016990-ot1wi3xi 221 10 immunoglobulin immunoglobulin NN cord-016990-ot1wi3xi 221 11 M m NN cord-016990-ot1wi3xi 221 12 or or CC cord-016990-ot1wi3xi 221 13 rising rise VBG cord-016990-ot1wi3xi 221 14 S.R. S.R. NNP cord-016990-ot1wi3xi 221 15 Zaki Zaki NNP cord-016990-ot1wi3xi 221 16 and and CC cord-016990-ot1wi3xi 221 17 CD CD NNP cord-016990-ot1wi3xi 221 18 . . . cord-016990-ot1wi3xi 222 1 Paddock paddock NN cord-016990-ot1wi3xi 222 2 titers titer NNS cord-016990-ot1wi3xi 222 3 of of IN cord-016990-ot1wi3xi 222 4 immunoglobulin immunoglobulin NN cord-016990-ot1wi3xi 222 5 G g NN cord-016990-ot1wi3xi 222 6 in in IN cord-016990-ot1wi3xi 222 7 patient patient NN cord-016990-ot1wi3xi 222 8 sera sera NNP cord-016990-ot1wi3xi 222 9 and and CC cord-016990-ot1wi3xi 222 10 is be VBZ cord-016990-ot1wi3xi 222 11 considered consider VBN cord-016990-ot1wi3xi 222 12 the the DT cord-016990-ot1wi3xi 222 13 method method NN cord-016990-ot1wi3xi 222 14 of of IN cord-016990-ot1wi3xi 222 15 choice choice NN cord-016990-ot1wi3xi 222 16 for for IN cord-016990-ot1wi3xi 222 17 laboratory laboratory NN cord-016990-ot1wi3xi 222 18 confirmation confirmation NN cord-016990-ot1wi3xi 222 19 of of IN cord-016990-ot1wi3xi 222 20 HPS HPS NNP cord-016990-ot1wi3xi 222 21 . . . cord-016990-ot1wi3xi 223 1 Immunofluorescent Immunofluorescent NNP cord-016990-ot1wi3xi 223 2 assays assay NNS cord-016990-ot1wi3xi 223 3 and and CC cord-016990-ot1wi3xi 223 4 enzyme enzyme NN cord-016990-ot1wi3xi 223 5 - - HYPH cord-016990-ot1wi3xi 223 6 linked link VBN cord-016990-ot1wi3xi 223 7 immunosorbent immunosorbent JJ cord-016990-ot1wi3xi 223 8 assays assay NNS cord-016990-ot1wi3xi 223 9 ( ( -LRB- cord-016990-ot1wi3xi 223 10 ELISAs elisa NNS cord-016990-ot1wi3xi 223 11 ) ) -RRB- cord-016990-ot1wi3xi 223 12 , , , cord-016990-ot1wi3xi 223 13 which which WDT cord-016990-ot1wi3xi 223 14 demonstrate demonstrate VBP cord-016990-ot1wi3xi 223 15 the the DT cord-016990-ot1wi3xi 223 16 presence presence NN cord-016990-ot1wi3xi 223 17 of of IN cord-016990-ot1wi3xi 223 18 specific specific JJ cord-016990-ot1wi3xi 223 19 antihantaviral antihantaviral JJ cord-016990-ot1wi3xi 223 20 antibodies antibody NNS cord-016990-ot1wi3xi 223 21 , , , cord-016990-ot1wi3xi 223 22 are be VBP cord-016990-ot1wi3xi 223 23 currently currently RB cord-016990-ot1wi3xi 223 24 used use VBN cord-016990-ot1wi3xi 223 25 as as IN cord-016990-ot1wi3xi 223 26 rapid rapid JJ cord-016990-ot1wi3xi 223 27 diagnostic diagnostic JJ cord-016990-ot1wi3xi 223 28 tests test NNS cord-016990-ot1wi3xi 223 29 and and CC cord-016990-ot1wi3xi 223 30 provide provide VB cord-016990-ot1wi3xi 223 31 results result NNS cord-016990-ot1wi3xi 223 32 within within IN cord-016990-ot1wi3xi 223 33 a a DT cord-016990-ot1wi3xi 223 34 few few JJ cord-016990-ot1wi3xi 223 35 hours hour NNS cord-016990-ot1wi3xi 223 36 . . . cord-016990-ot1wi3xi 224 1 Recently recently RB cord-016990-ot1wi3xi 224 2 , , , cord-016990-ot1wi3xi 224 3 synthetic synthetic JJ cord-016990-ot1wi3xi 224 4 hantaviral hantaviral NNP cord-016990-ot1wi3xi 224 5 nucleocapsid nucleocapsid NN cord-016990-ot1wi3xi 224 6 proteins protein NNS cord-016990-ot1wi3xi 224 7 have have VBP cord-016990-ot1wi3xi 224 8 been be VBN cord-016990-ot1wi3xi 224 9 used use VBN cord-016990-ot1wi3xi 224 10 to to TO cord-016990-ot1wi3xi 224 11 improve improve VB cord-016990-ot1wi3xi 224 12 the the DT cord-016990-ot1wi3xi 224 13 sensitivity sensitivity NN cord-016990-ot1wi3xi 224 14 and and CC cord-016990-ot1wi3xi 224 15 specificity specificity NN cord-016990-ot1wi3xi 224 16 of of IN cord-016990-ot1wi3xi 224 17 serologic serologic JJ cord-016990-ot1wi3xi 224 18 assays assay NNS cord-016990-ot1wi3xi 224 19 . . . cord-016990-ot1wi3xi 225 1 These these DT cord-016990-ot1wi3xi 225 2 proteins protein NNS cord-016990-ot1wi3xi 225 3 are be VBP cord-016990-ot1wi3xi 225 4 more more RBR cord-016990-ot1wi3xi 225 5 available available JJ cord-016990-ot1wi3xi 225 6 than than IN cord-016990-ot1wi3xi 225 7 inactivated inactivate VBN cord-016990-ot1wi3xi 225 8 hantaviral hantaviral JJ cord-016990-ot1wi3xi 225 9 antigens antigen NNS cord-016990-ot1wi3xi 225 10 . . . cord-016990-ot1wi3xi 226 1 81 81 CD cord-016990-ot1wi3xi 226 2 . . . cord-016990-ot1wi3xi 227 1 82 82 CD cord-016990-ot1wi3xi 227 2 Polymerase polymerase NN cord-016990-ot1wi3xi 227 3 chain chain NN cord-016990-ot1wi3xi 227 4 reaction reaction NN cord-016990-ot1wi3xi 227 5 detects detect VBZ cord-016990-ot1wi3xi 227 6 viral viral JJ cord-016990-ot1wi3xi 227 7 RNA rna NN cord-016990-ot1wi3xi 227 8 in in IN cord-016990-ot1wi3xi 227 9 blood blood NN cord-016990-ot1wi3xi 227 10 and and CC cord-016990-ot1wi3xi 227 11 tissues tissue NNS cord-016990-ot1wi3xi 227 12 and and CC cord-016990-ot1wi3xi 227 13 is be VBZ cord-016990-ot1wi3xi 227 14 extremely extremely RB cord-016990-ot1wi3xi 227 15 useful useful JJ cord-016990-ot1wi3xi 227 16 for for IN cord-016990-ot1wi3xi 227 17 diagnostic diagnostic JJ cord-016990-ot1wi3xi 227 18 and and CC cord-016990-ot1wi3xi 227 19 epidemiologic epidemiologic JJ cord-016990-ot1wi3xi 227 20 purposes purpose NNS cord-016990-ot1wi3xi 227 21 . . . cord-016990-ot1wi3xi 228 1 Hantaviral Hantaviral NNP cord-016990-ot1wi3xi 228 2 RNA RNA NNP cord-016990-ot1wi3xi 228 3 can can MD cord-016990-ot1wi3xi 228 4 also also RB cord-016990-ot1wi3xi 228 5 be be VB cord-016990-ot1wi3xi 228 6 detected detect VBN cord-016990-ot1wi3xi 228 7 in in IN cord-016990-ot1wi3xi 228 8 formalin formalin NN cord-016990-ot1wi3xi 228 9 - - HYPH cord-016990-ot1wi3xi 228 10 fixed fix VBN cord-016990-ot1wi3xi 228 11 , , , cord-016990-ot1wi3xi 228 12 paraffin paraffin NN cord-016990-ot1wi3xi 228 13 - - HYPH cord-016990-ot1wi3xi 228 14 embedded embed VBN cord-016990-ot1wi3xi 228 15 archival archival JJ cord-016990-ot1wi3xi 228 16 tissue tissue NN cord-016990-ot1wi3xi 228 17 by by IN cord-016990-ot1wi3xi 228 18 reverse reverse NN cord-016990-ot1wi3xi 228 19 - - HYPH cord-016990-ot1wi3xi 228 20 transcriptase transcriptase NN cord-016990-ot1wi3xi 228 21 ( ( -LRB- cord-016990-ot1wi3xi 228 22 RT)-PCR.83 RT)-PCR.83 NNP cord-016990-ot1wi3xi 228 23 Immunohistochemistry Immunohistochemistry NNP cord-016990-ot1wi3xi 228 24 testing testing NN cord-016990-ot1wi3xi 228 25 of of IN cord-016990-ot1wi3xi 228 26 formalin formalin NN cord-016990-ot1wi3xi 228 27 - - HYPH cord-016990-ot1wi3xi 228 28 fixed fix VBN cord-016990-ot1wi3xi 228 29 tissues tissue NNS cord-016990-ot1wi3xi 228 30 can can MD cord-016990-ot1wi3xi 228 31 be be VB cord-016990-ot1wi3xi 228 32 used use VBN cord-016990-ot1wi3xi 228 33 to to TO cord-016990-ot1wi3xi 228 34 detect detect VB cord-016990-ot1wi3xi 228 35 hantavirus hantavirus NN cord-016990-ot1wi3xi 228 36 antigens antigen NNS cord-016990-ot1wi3xi 228 37 , , , cord-016990-ot1wi3xi 228 38 and and CC cord-016990-ot1wi3xi 228 39 is be VBZ cord-016990-ot1wi3xi 228 40 a a DT cord-016990-ot1wi3xi 228 41 sensitive sensitive JJ cord-016990-ot1wi3xi 228 42 method method NN cord-016990-ot1wi3xi 228 43 to to TO cord-016990-ot1wi3xi 228 44 confirm confirm VB cord-016990-ot1wi3xi 228 45 hantaviral hantaviral JJ cord-016990-ot1wi3xi 228 46 infections infection NNS cord-016990-ot1wi3xi 228 47 . . . cord-016990-ot1wi3xi 229 1 72 72 CD cord-016990-ot1wi3xi 230 1 It -PRON- PRP cord-016990-ot1wi3xi 230 2 has have VBZ cord-016990-ot1wi3xi 230 3 a a DT cord-016990-ot1wi3xi 230 4 unique unique JJ cord-016990-ot1wi3xi 230 5 role role NN cord-016990-ot1wi3xi 230 6 in in IN cord-016990-ot1wi3xi 230 7 the the DT cord-016990-ot1wi3xi 230 8 diagnosis diagnosis NN cord-016990-ot1wi3xi 230 9 of of IN cord-016990-ot1wi3xi 230 10 fatal fatal JJ cord-016990-ot1wi3xi 230 11 HPS hps NN cord-016990-ot1wi3xi 230 12 cases case NNS cord-016990-ot1wi3xi 230 13 when when WRB cord-016990-ot1wi3xi 230 14 serum serum NN cord-016990-ot1wi3xi 230 15 samples sample NNS cord-016990-ot1wi3xi 230 16 and and CC cord-016990-ot1wi3xi 230 17 frozen frozen JJ cord-016990-ot1wi3xi 230 18 tissues tissue NNS cord-016990-ot1wi3xi 230 19 are be VBP cord-016990-ot1wi3xi 230 20 unavailable unavailable JJ cord-016990-ot1wi3xi 230 21 but but CC cord-016990-ot1wi3xi 230 22 formalinfixed formalinfixed JJ cord-016990-ot1wi3xi 230 23 autopsy autopsy JJ cord-016990-ot1wi3xi 230 24 tissues tissue NNS cord-016990-ot1wi3xi 230 25 are be VBP cord-016990-ot1wi3xi 230 26 obtainable obtainable JJ cord-016990-ot1wi3xi 230 27 . . . cord-016990-ot1wi3xi 231 1 84 84 CD cord-016990-ot1wi3xi 232 1 • • NNP cord-016990-ot1wi3xi 232 2 85 85 CD cord-016990-ot1wi3xi 232 3 Severe severe JJ cord-016990-ot1wi3xi 232 4 Acute acute JJ cord-016990-ot1wi3xi 232 5 Respiratory respiratory JJ cord-016990-ot1wi3xi 232 6 Syndrome syndrome NN cord-016990-ot1wi3xi 233 1 The the DT cord-016990-ot1wi3xi 233 2 causative causative JJ cord-016990-ot1wi3xi 233 3 agent agent NN cord-016990-ot1wi3xi 233 4 of of IN cord-016990-ot1wi3xi 233 5 SARS SARS NNP cord-016990-ot1wi3xi 233 6 is be VBZ cord-016990-ot1wi3xi 233 7 an an DT cord-016990-ot1wi3xi 233 8 enveloped envelop VBN cord-016990-ot1wi3xi 233 9 , , , cord-016990-ot1wi3xi 233 10 positivestranded positivestranded JJ cord-016990-ot1wi3xi 233 11 RNA RNA NNP cord-016990-ot1wi3xi 233 12 virus virus NN cord-016990-ot1wi3xi 233 13 that that WDT cord-016990-ot1wi3xi 233 14 is be VBZ cord-016990-ot1wi3xi 233 15 a a DT cord-016990-ot1wi3xi 233 16 member member NN cord-016990-ot1wi3xi 233 17 of of IN cord-016990-ot1wi3xi 233 18 the the DT cord-016990-ot1wi3xi 233 19 genus genus JJ cord-016990-ot1wi3xi 233 20 Coronavirus Coronavirus NNP cord-016990-ot1wi3xi 233 21 , , , cord-016990-ot1wi3xi 233 22 of of IN cord-016990-ot1wi3xi 233 23 the the DT cord-016990-ot1wi3xi 233 24 family family NN cord-016990-ot1wi3xi 233 25 Coronaviridae Coronaviridae NNP cord-016990-ot1wi3xi 233 26 . . . cord-016990-ot1wi3xi 234 1 Corona corona NN cord-016990-ot1wi3xi 234 2 viruses virus NNS cord-016990-ot1wi3xi 234 3 have have VBP cord-016990-ot1wi3xi 234 4 the the DT cord-016990-ot1wi3xi 234 5 largest large JJS cord-016990-ot1wi3xi 234 6 genomes genome NNS cord-016990-ot1wi3xi 234 7 of of IN cord-016990-ot1wi3xi 234 8 all all DT cord-016990-ot1wi3xi 234 9 RNA RNA NNP cord-016990-ot1wi3xi 234 10 viruses virus NNS cord-016990-ot1wi3xi 234 11 and and CC cord-016990-ot1wi3xi 234 12 replicate replicate VB cord-016990-ot1wi3xi 234 13 by by IN cord-016990-ot1wi3xi 234 14 a a DT cord-016990-ot1wi3xi 234 15 unique unique JJ cord-016990-ot1wi3xi 234 16 mechanism mechanism NN cord-016990-ot1wi3xi 234 17 that that WDT cord-016990-ot1wi3xi 234 18 results result VBZ cord-016990-ot1wi3xi 234 19 in in IN cord-016990-ot1wi3xi 234 20 a a DT cord-016990-ot1wi3xi 234 21 high high JJ cord-016990-ot1wi3xi 234 22 frequency frequency NN cord-016990-ot1wi3xi 234 23 of of IN cord-016990-ot1wi3xi 234 24 recombination recombination NN cord-016990-ot1wi3xi 234 25 . . . cord-016990-ot1wi3xi 235 1 Maturation maturation NN cord-016990-ot1wi3xi 235 2 of of IN cord-016990-ot1wi3xi 235 3 SARS SARS NNP cord-016990-ot1wi3xi 235 4 coronavirus coronavirus NN cord-016990-ot1wi3xi 235 5 ( ( -LRB- cord-016990-ot1wi3xi 235 6 SARS SARS NNP cord-016990-ot1wi3xi 235 7 - - HYPH cord-016990-ot1wi3xi 235 8 Co Co NNP cord-016990-ot1wi3xi 235 9 V V NNP cord-016990-ot1wi3xi 235 10 ) ) -RRB- cord-016990-ot1wi3xi 235 11 is be VBZ cord-016990-ot1wi3xi 235 12 similar similar JJ cord-016990-ot1wi3xi 235 13 to to IN cord-016990-ot1wi3xi 235 14 features feature NNS cord-016990-ot1wi3xi 235 15 previously previously RB cord-016990-ot1wi3xi 235 16 described describe VBN cord-016990-ot1wi3xi 235 17 for for IN cord-016990-ot1wi3xi 235 18 other other JJ cord-016990-ot1wi3xi 235 19 coronaviruses coronaviruse NNS cord-016990-ot1wi3xi 235 20 . . . cord-016990-ot1wi3xi 236 1 8 8 CD cord-016990-ot1wi3xi 236 2 6 6 CD cord-016990-ot1wi3xi 236 3 - - SYM cord-016990-ot1wi3xi 236 4 9 9 CD cord-016990-ot1wi3xi 236 5 0Virions 0virions CD cord-016990-ot1wi3xi 236 6 form form NN cord-016990-ot1wi3xi 236 7 by by IN cord-016990-ot1wi3xi 236 8 alignment alignment NN cord-016990-ot1wi3xi 236 9 of of IN cord-016990-ot1wi3xi 236 10 the the DT cord-016990-ot1wi3xi 236 11 helical helical JJ cord-016990-ot1wi3xi 236 12 nucleocapsids nucleocapsid NNS cord-016990-ot1wi3xi 236 13 along along IN cord-016990-ot1wi3xi 236 14 the the DT cord-016990-ot1wi3xi 236 15 membranes membrane NNS cord-016990-ot1wi3xi 236 16 of of IN cord-016990-ot1wi3xi 236 17 the the DT cord-016990-ot1wi3xi 236 18 endoplasmic endoplasmic NN cord-016990-ot1wi3xi 236 19 reticulum reticulum NN cord-016990-ot1wi3xi 236 20 or or CC cord-016990-ot1wi3xi 236 21 Golgi Golgi NNP cord-016990-ot1wi3xi 236 22 complex complex NN cord-016990-ot1wi3xi 236 23 and and CC cord-016990-ot1wi3xi 236 24 acquire acquire VB cord-016990-ot1wi3xi 236 25 an an DT cord-016990-ot1wi3xi 236 26 envelope envelope NN cord-016990-ot1wi3xi 236 27 by by IN cord-016990-ot1wi3xi 236 28 budding bud VBG cord-016990-ot1wi3xi 236 29 into into IN cord-016990-ot1wi3xi 236 30 the the DT cord-016990-ot1wi3xi 236 31 cisternae cisternae NN cord-016990-ot1wi3xi 236 32 . . . cord-016990-ot1wi3xi 237 1 The the DT cord-016990-ot1wi3xi 237 2 cellular cellular JJ cord-016990-ot1wi3xi 237 3 vesicles vesicle NNS cord-016990-ot1wi3xi 237 4 become become VBP cord-016990-ot1wi3xi 237 5 filled fill VBN cord-016990-ot1wi3xi 237 6 with with IN cord-016990-ot1wi3xi 237 7 virions virion NNS cord-016990-ot1wi3xi 237 8 and and CC cord-016990-ot1wi3xi 237 9 progress progress NN cord-016990-ot1wi3xi 237 10 to to IN cord-016990-ot1wi3xi 237 11 the the DT cord-016990-ot1wi3xi 237 12 cell cell NN cord-016990-ot1wi3xi 237 13 surface surface NN cord-016990-ot1wi3xi 237 14 for for IN cord-016990-ot1wi3xi 237 15 release release NN cord-016990-ot1wi3xi 237 16 of of IN cord-016990-ot1wi3xi 237 17 the the DT cord-016990-ot1wi3xi 237 18 virus virus NN cord-016990-ot1wi3xi 237 19 particles particle NNS cord-016990-ot1wi3xi 237 20 ; ; : cord-016990-ot1wi3xi 237 21 large large JJ cord-016990-ot1wi3xi 237 22 numbers number NNS cord-016990-ot1wi3xi 237 23 of of IN cord-016990-ot1wi3xi 237 24 particles particle NNS cord-016990-ot1wi3xi 237 25 remain remain VBP cord-016990-ot1wi3xi 237 26 adherent adherent JJ cord-016990-ot1wi3xi 237 27 to to IN cord-016990-ot1wi3xi 237 28 the the DT cord-016990-ot1wi3xi 237 29 plasma plasma NN cord-016990-ot1wi3xi 237 30 membrane membrane NN cord-016990-ot1wi3xi 237 31 at at IN cord-016990-ot1wi3xi 237 32 the the DT cord-016990-ot1wi3xi 237 33 cell cell NN cord-016990-ot1wi3xi 237 34 surface surface NN cord-016990-ot1wi3xi 237 35 . . . cord-016990-ot1wi3xi 238 1 Severe severe JJ cord-016990-ot1wi3xi 238 2 acute acute JJ cord-016990-ot1wi3xi 238 3 respiratory respiratory JJ cord-016990-ot1wi3xi 238 4 syndrome syndrome NN cord-016990-ot1wi3xi 238 5 was be VBD cord-016990-ot1wi3xi 238 6 recognized recognize VBN cord-016990-ot1wi3xi 238 7 during during IN cord-016990-ot1wi3xi 238 8 a a DT cord-016990-ot1wi3xi 238 9 global global JJ cord-016990-ot1wi3xi 238 10 outbreak outbreak NN cord-016990-ot1wi3xi 238 11 of of IN cord-016990-ot1wi3xi 238 12 severe severe JJ cord-016990-ot1wi3xi 238 13 pneumonia pneumonia NN cord-016990-ot1wi3xi 238 14 that that WDT cord-016990-ot1wi3xi 238 15 began begin VBD cord-016990-ot1wi3xi 238 16 in in IN cord-016990-ot1wi3xi 238 17 late late JJ cord-016990-ot1wi3xi 238 18 2002 2002 CD cord-016990-ot1wi3xi 238 19 in in IN cord-016990-ot1wi3xi 238 20 Guangdong Guangdong NNP cord-016990-ot1wi3xi 238 21 Province Province NNP cord-016990-ot1wi3xi 238 22 , , , cord-016990-ot1wi3xi 238 23 China China NNP cord-016990-ot1wi3xi 238 24 , , , cord-016990-ot1wi3xi 238 25 and and CC cord-016990-ot1wi3xi 238 26 gained gain VBD cord-016990-ot1wi3xi 238 27 prominence prominence NN cord-016990-ot1wi3xi 238 28 in in IN cord-016990-ot1wi3xi 238 29 early early JJ cord-016990-ot1wi3xi 238 30 2003 2003 CD cord-016990-ot1wi3xi 238 31 as as IN cord-016990-ot1wi3xi 238 32 cases case NNS cord-016990-ot1wi3xi 238 33 were be VBD cord-016990-ot1wi3xi 238 34 identified identify VBN cord-016990-ot1wi3xi 238 35 in in IN cord-016990-ot1wi3xi 238 36 more more JJR cord-016990-ot1wi3xi 238 37 than than IN cord-016990-ot1wi3xi 238 38 two two CD cord-016990-ot1wi3xi 238 39 dozen dozen NN cord-016990-ot1wi3xi 238 40 countries country NNS cord-016990-ot1wi3xi 238 41 in in IN cord-016990-ot1wi3xi 238 42 Asia Asia NNP cord-016990-ot1wi3xi 238 43 , , , cord-016990-ot1wi3xi 238 44 Europe Europe NNP cord-016990-ot1wi3xi 238 45 , , , cord-016990-ot1wi3xi 238 46 North North NNP cord-016990-ot1wi3xi 238 47 America America NNP cord-016990-ot1wi3xi 238 48 , , , cord-016990-ot1wi3xi 238 49 and and CC cord-016990-ot1wi3xi 238 50 South South NNP cord-016990-ot1wi3xi 238 51 America America NNP cord-016990-ot1wi3xi 238 52 . . . cord-016990-ot1wi3xi 239 1 The the DT cord-016990-ot1wi3xi 239 2 disease disease NN cord-016990-ot1wi3xi 239 3 causes cause VBZ cord-016990-ot1wi3xi 239 4 an an DT cord-016990-ot1wi3xi 239 5 influenza influenza NN cord-016990-ot1wi3xi 239 6 - - HYPH cord-016990-ot1wi3xi 239 7 like like JJ cord-016990-ot1wi3xi 239 8 illness illness NN cord-016990-ot1wi3xi 239 9 with with IN cord-016990-ot1wi3xi 239 10 fever fever NN cord-016990-ot1wi3xi 239 11 , , , cord-016990-ot1wi3xi 239 12 cough cough NN cord-016990-ot1wi3xi 239 13 , , , cord-016990-ot1wi3xi 239 14 dyspnea dyspnea NN cord-016990-ot1wi3xi 239 15 , , , cord-016990-ot1wi3xi 239 16 and and CC cord-016990-ot1wi3xi 239 17 headache headache NN cord-016990-ot1wi3xi 239 18 , , , cord-016990-ot1wi3xi 239 19 and and CC cord-016990-ot1wi3xi 239 20 in in IN cord-016990-ot1wi3xi 239 21 severe severe JJ cord-016990-ot1wi3xi 239 22 cases case NNS cord-016990-ot1wi3xi 239 23 it -PRON- PRP cord-016990-ot1wi3xi 239 24 can can MD cord-016990-ot1wi3xi 239 25 cause cause VB cord-016990-ot1wi3xi 239 26 death death NN cord-016990-ot1wi3xi 239 27 in in IN cord-016990-ot1wi3xi 239 28 humans human NNS cord-016990-ot1wi3xi 239 29 . . . cord-016990-ot1wi3xi 240 1 Person person NN cord-016990-ot1wi3xi 240 2 - - HYPH cord-016990-ot1wi3xi 240 3 toperson toperson NN cord-016990-ot1wi3xi 240 4 transmission transmission NN cord-016990-ot1wi3xi 240 5 , , , cord-016990-ot1wi3xi 240 6 combined combine VBN cord-016990-ot1wi3xi 240 7 with with IN cord-016990-ot1wi3xi 240 8 international international JJ cord-016990-ot1wi3xi 240 9 travel travel NN cord-016990-ot1wi3xi 240 10 of of IN cord-016990-ot1wi3xi 240 11 infected infected JJ cord-016990-ot1wi3xi 240 12 persons person NNS cord-016990-ot1wi3xi 240 13 , , , cord-016990-ot1wi3xi 240 14 accelerated accelerate VBD cord-016990-ot1wi3xi 240 15 the the DT cord-016990-ot1wi3xi 240 16 worldwide worldwide JJ cord-016990-ot1wi3xi 240 17 spread spread NN cord-016990-ot1wi3xi 240 18 of of IN cord-016990-ot1wi3xi 240 19 the the DT cord-016990-ot1wi3xi 240 20 illness illness NN cord-016990-ot1wi3xi 240 21 . . . cord-016990-ot1wi3xi 241 1 5 5 LS cord-016990-ot1wi3xi 242 1 • • NNP cord-016990-ot1wi3xi 242 2 13 13 CD cord-016990-ot1wi3xi 242 3 . . . cord-016990-ot1wi3xi 243 1 91 91 CD cord-016990-ot1wi3xi 244 1 Several several JJ cord-016990-ot1wi3xi 244 2 reports report NNS cord-016990-ot1wi3xi 244 3 have have VBP cord-016990-ot1wi3xi 244 4 described describe VBN cord-016990-ot1wi3xi 244 5 diffuse diffuse JJ cord-016990-ot1wi3xi 244 6 alveolar alveolar NN cord-016990-ot1wi3xi 244 7 damage damage NN cord-016990-ot1wi3xi 244 8 with with IN cord-016990-ot1wi3xi 244 9 various various JJ cord-016990-ot1wi3xi 244 10 levels level NNS cord-016990-ot1wi3xi 244 11 of of IN cord-016990-ot1wi3xi 244 12 progression progression NN cord-016990-ot1wi3xi 244 13 and and CC cord-016990-ot1wi3xi 244 14 severity severity NN cord-016990-ot1wi3xi 244 15 as as IN cord-016990-ot1wi3xi 244 16 the the DT cord-016990-ot1wi3xi 244 17 main main JJ cord-016990-ot1wi3xi 244 18 histopathologic histopathologic JJ cord-016990-ot1wi3xi 244 19 findings finding NNS cord-016990-ot1wi3xi 244 20 in in IN cord-016990-ot1wi3xi 244 21 SARS SARS NNP cord-016990-ot1wi3xi 244 22 patients patient NNS cord-016990-ot1wi3xi 244 23 ( ( -LRB- cord-016990-ot1wi3xi 244 24 Fig Fig NNP cord-016990-ot1wi3xi 244 25 . . . cord-016990-ot1wi3xi 245 1 11 11 CD cord-016990-ot1wi3xi 246 1 .4A .4A . cord-016990-ot1wi3xi 247 1 , , , cord-016990-ot1wi3xi 248 1 B)Y·92 B)Y·92 NNP cord-016990-ot1wi3xi 248 2 - - HYPH cord-016990-ot1wi3xi 248 3 98 98 CD cord-016990-ot1wi3xi 248 4 Lungs lung NNS cord-016990-ot1wi3xi 248 5 typically typically RB cord-016990-ot1wi3xi 248 6 show show VBP cord-016990-ot1wi3xi 248 7 changes change NNS cord-016990-ot1wi3xi 248 8 described describe VBN cord-016990-ot1wi3xi 248 9 for for IN cord-016990-ot1wi3xi 248 10 the the DT cord-016990-ot1wi3xi 248 11 proliferative proliferative JJ cord-016990-ot1wi3xi 248 12 phase phase NN cord-016990-ot1wi3xi 248 13 of of IN cord-016990-ot1wi3xi 248 14 diffuse diffuse JJ cord-016990-ot1wi3xi 248 15 alveolar alveolar NN cord-016990-ot1wi3xi 248 16 damage damage NN cord-016990-ot1wi3xi 248 17 , , , cord-016990-ot1wi3xi 248 18 with with IN cord-016990-ot1wi3xi 248 19 hyaline hyaline JJ cord-016990-ot1wi3xi 248 20 - - HYPH cord-016990-ot1wi3xi 248 21 membrane membrane NN cord-016990-ot1wi3xi 248 22 formation formation NN cord-016990-ot1wi3xi 248 23 , , , cord-016990-ot1wi3xi 248 24 desquamation desquamation NN cord-016990-ot1wi3xi 248 25 of of IN cord-016990-ot1wi3xi 248 26 epithelial epithelial JJ cord-016990-ot1wi3xi 248 27 cells cell NNS cord-016990-ot1wi3xi 248 28 , , , cord-016990-ot1wi3xi 248 29 fibrin fibrin NN cord-016990-ot1wi3xi 248 30 deposit deposit NN cord-016990-ot1wi3xi 248 31 in in IN cord-016990-ot1wi3xi 248 32 the the DT cord-016990-ot1wi3xi 248 33 alveolar alveolar JJ cord-016990-ot1wi3xi 248 34 space space NN cord-016990-ot1wi3xi 248 35 , , , cord-016990-ot1wi3xi 248 36 and and CC cord-016990-ot1wi3xi 248 37 hyperplasia hyperplasia NN cord-016990-ot1wi3xi 248 38 of of IN cord-016990-ot1wi3xi 248 39 type type NN cord-016990-ot1wi3xi 248 40 2 2 CD cord-016990-ot1wi3xi 248 41 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 248 42 . . . cord-016990-ot1wi3xi 249 1 Increased increase VBN cord-016990-ot1wi3xi 249 2 mononuclear mononuclear NN cord-016990-ot1wi3xi 249 3 infiltrate infiltrate NN cord-016990-ot1wi3xi 249 4 in in IN cord-016990-ot1wi3xi 249 5 the the DT cord-016990-ot1wi3xi 249 6 interstitium interstitium NN cord-016990-ot1wi3xi 249 7 can can MD cord-016990-ot1wi3xi 249 8 be be VB cord-016990-ot1wi3xi 249 9 seen see VBN cord-016990-ot1wi3xi 249 10 in in IN cord-016990-ot1wi3xi 249 11 some some DT cord-016990-ot1wi3xi 249 12 cases case NNS cord-016990-ot1wi3xi 249 13 . . . cord-016990-ot1wi3xi 250 1 Other other JJ cord-016990-ot1wi3xi 250 2 findings finding NNS cord-016990-ot1wi3xi 250 3 identified identify VBN cord-016990-ot1wi3xi 250 4 in in IN cord-016990-ot1wi3xi 250 5 some some DT cord-016990-ot1wi3xi 250 6 patients patient NNS cord-016990-ot1wi3xi 250 7 included include VBD cord-016990-ot1wi3xi 250 8 focal focal JJ cord-016990-ot1wi3xi 250 9 intra intra JJ cord-016990-ot1wi3xi 250 10 alveolar alveolar NN cord-016990-ot1wi3xi 250 11 hemorrhage hemorrhage NN cord-016990-ot1wi3xi 250 12 , , , cord-016990-ot1wi3xi 250 13 necrotic necrotic JJ cord-016990-ot1wi3xi 250 14 inflammatory inflammatory JJ cord-016990-ot1wi3xi 250 15 debris debris NN cord-016990-ot1wi3xi 250 16 in in IN cord-016990-ot1wi3xi 250 17 small small JJ cord-016990-ot1wi3xi 250 18 airways airway NNS cord-016990-ot1wi3xi 250 19 , , , cord-016990-ot1wi3xi 250 20 and and CC cord-016990-ot1wi3xi 250 21 organizing organize VBG cord-016990-ot1wi3xi 250 22 pneumonia pneumonia NN cord-016990-ot1wi3xi 250 23 . . . cord-016990-ot1wi3xi 251 1 In in IN cord-016990-ot1wi3xi 251 2 addition addition NN cord-016990-ot1wi3xi 251 3 , , , cord-016990-ot1wi3xi 251 4 multinucleated multinucleate VBN cord-016990-ot1wi3xi 251 5 syncytial syncytial JJ cord-016990-ot1wi3xi 251 6 cells cell NNS cord-016990-ot1wi3xi 251 7 may may MD cord-016990-ot1wi3xi 251 8 be be VB cord-016990-ot1wi3xi 251 9 seen see VBN cord-016990-ot1wi3xi 251 10 in in IN cord-016990-ot1wi3xi 251 11 the the DT cord-016990-ot1wi3xi 251 12 intraalveolar intraalveolar NNP cord-016990-ot1wi3xi 251 13 spaces space NNS cord-016990-ot1wi3xi 251 14 of of IN cord-016990-ot1wi3xi 251 15 some some DT cord-016990-ot1wi3xi 251 16 patients patient NNS cord-016990-ot1wi3xi 251 17 who who WP cord-016990-ot1wi3xi 251 18 died die VBD cord-016990-ot1wi3xi 251 19 14 14 CD cord-016990-ot1wi3xi 251 20 days day NNS cord-016990-ot1wi3xi 251 21 or or CC cord-016990-ot1wi3xi 251 22 more more JJR cord-016990-ot1wi3xi 251 23 after after IN cord-016990-ot1wi3xi 251 24 onset onset NN cord-016990-ot1wi3xi 251 25 of of IN cord-016990-ot1wi3xi 251 26 illness illness NN cord-016990-ot1wi3xi 251 27 ( ( -LRB- cord-016990-ot1wi3xi 251 28 Fig fig NN cord-016990-ot1wi3xi 251 29 . . . cord-016990-ot1wi3xi 251 30 1l 1l CD cord-016990-ot1wi3xi 251 31 .4C .4C . cord-016990-ot1wi3xi 251 32 ) ) -RRB- cord-016990-ot1wi3xi 251 33 . . . cord-016990-ot1wi3xi 252 1 Infection infection NN cord-016990-ot1wi3xi 252 2 with with IN cord-016990-ot1wi3xi 252 3 some some DT cord-016990-ot1wi3xi 252 4 coronaviruses coronaviruse NNS cord-016990-ot1wi3xi 252 5 , , , cord-016990-ot1wi3xi 252 6 including include VBG cord-016990-ot1wi3xi 252 7 SARS SARS NNP cord-016990-ot1wi3xi 252 8 - - HYPH cord-016990-ot1wi3xi 252 9 Co Co NNP cord-016990-ot1wi3xi 252 10 V V NNP cord-016990-ot1wi3xi 252 11 , , , cord-016990-ot1wi3xi 252 12 is be VBZ cord-016990-ot1wi3xi 252 13 known know VBN cord-016990-ot1wi3xi 252 14 to to TO cord-016990-ot1wi3xi 252 15 induce induce VB cord-016990-ot1wi3xi 252 16 cell cell NN cord-016990-ot1wi3xi 252 17 fusion fusion NN cord-016990-ot1wi3xi 252 18 in in IN cord-016990-ot1wi3xi 252 19 culture culture NN cord-016990-ot1wi3xi 252 20 producing produce VBG cord-016990-ot1wi3xi 252 21 syncytial syncytial JJ cord-016990-ot1wi3xi 252 22 cells cell NNS cord-016990-ot1wi3xi 252 23 similar similar JJ cord-016990-ot1wi3xi 252 24 to to IN cord-016990-ot1wi3xi 252 25 those those DT cord-016990-ot1wi3xi 252 26 sometimes sometimes RB cord-016990-ot1wi3xi 252 27 observed observe VBN cord-016990-ot1wi3xi 252 28 in in IN cord-016990-ot1wi3xi 252 29 lungs lung NNS cord-016990-ot1wi3xi 252 30 of of IN cord-016990-ot1wi3xi 252 31 patients patient NNS cord-016990-ot1wi3xi 252 32 who who WP cord-016990-ot1wi3xi 252 33 die die VBP cord-016990-ot1wi3xi 252 34 from from IN cord-016990-ot1wi3xi 252 35 SARS SARS NNP cord-016990-ot1wi3xi 252 36 . . . cord-016990-ot1wi3xi 253 1 These these DT cord-016990-ot1wi3xi 253 2 cells cell NNS cord-016990-ot1wi3xi 253 3 contain contain VBP cord-016990-ot1wi3xi 253 4 abundant abundant JJ cord-016990-ot1wi3xi 253 5 vacuolated vacuolate VBN cord-016990-ot1wi3xi 253 6 cytoplasm cytoplasm NN cord-016990-ot1wi3xi 253 7 with with IN cord-016990-ot1wi3xi 253 8 cleaved cleaved JJ cord-016990-ot1wi3xi 253 9 and and CC cord-016990-ot1wi3xi 253 10 convoluted convoluted JJ cord-016990-ot1wi3xi 253 11 nuclei nucleus NNS cord-016990-ot1wi3xi 253 12 , , , cord-016990-ot1wi3xi 253 13 but but CC cord-016990-ot1wi3xi 253 14 without without IN cord-016990-ot1wi3xi 253 15 obvious obvious JJ cord-016990-ot1wi3xi 253 16 intranuclear intranuclear NN cord-016990-ot1wi3xi 253 17 or or CC cord-016990-ot1wi3xi 253 18 intracytoplasmic intracytoplasmic JJ cord-016990-ot1wi3xi 253 19 viral viral JJ cord-016990-ot1wi3xi 253 20 inclusions inclusion NNS cord-016990-ot1wi3xi 253 21 . . . cord-016990-ot1wi3xi 254 1 The the DT cord-016990-ot1wi3xi 254 2 ISH ISH NNP cord-016990-ot1wi3xi 254 3 and and CC cord-016990-ot1wi3xi 254 4 IHC IHC NNP cord-016990-ot1wi3xi 254 5 studies study NNS cord-016990-ot1wi3xi 254 6 of of IN cord-016990-ot1wi3xi 254 7 tissues tissue NNS cord-016990-ot1wi3xi 254 8 from from IN cord-016990-ot1wi3xi 254 9 SARS SARS NNP cord-016990-ot1wi3xi 254 10 patients patient NNS cord-016990-ot1wi3xi 254 11 have have VBP cord-016990-ot1wi3xi 254 12 identified identify VBN cord-016990-ot1wi3xi 254 13 corona corona NN cord-016990-ot1wi3xi 254 14 virus virus NN cord-016990-ot1wi3xi 254 15 infection infection NN cord-016990-ot1wi3xi 254 16 of of IN cord-016990-ot1wi3xi 254 17 upper upper JJ cord-016990-ot1wi3xi 254 18 airway airway NN cord-016990-ot1wi3xi 254 19 bronchiolar bronchiolar JJ cord-016990-ot1wi3xi 254 20 epithelium epithelium NN cord-016990-ot1wi3xi 254 21 ( ( -LRB- cord-016990-ot1wi3xi 254 22 Fig fig NN cord-016990-ot1wi3xi 254 23 . . . cord-016990-ot1wi3xi 255 1 11 11 CD cord-016990-ot1wi3xi 255 2 .4D_F).92,99 .4D_F).92,99 . cord-016990-ot1wi3xi 256 1 -101 -101 NN cord-016990-ot1wi3xi 256 2 Infected infected JJ cord-016990-ot1wi3xi 256 3 ciliated ciliated JJ cord-016990-ot1wi3xi 256 4 columnar columnar JJ cord-016990-ot1wi3xi 256 5 epithelial epithelial JJ cord-016990-ot1wi3xi 256 6 cells cell NNS cord-016990-ot1wi3xi 256 7 can can MD cord-016990-ot1wi3xi 256 8 be be VB cord-016990-ot1wi3xi 256 9 seen see VBN cord-016990-ot1wi3xi 256 10 focally focally RB cord-016990-ot1wi3xi 256 11 in in IN cord-016990-ot1wi3xi 256 12 lining line VBG cord-016990-ot1wi3xi 256 13 epithelium epithelium NN cord-016990-ot1wi3xi 256 14 of of IN cord-016990-ot1wi3xi 256 15 trachea trachea NN cord-016990-ot1wi3xi 256 16 and and CC cord-016990-ot1wi3xi 256 17 larger large JJR cord-016990-ot1wi3xi 256 18 bronchi bronchus NNS cord-016990-ot1wi3xi 256 19 ( ( -LRB- cord-016990-ot1wi3xi 256 20 Fig fig NN cord-016990-ot1wi3xi 256 21 . . . cord-016990-ot1wi3xi 257 1 11 11 CD cord-016990-ot1wi3xi 257 2 .4E .4E . cord-016990-ot1wi3xi 257 3 ) ) -RRB- cord-016990-ot1wi3xi 257 4 . . . cord-016990-ot1wi3xi 258 1 Many many JJ cord-016990-ot1wi3xi 258 2 of of IN cord-016990-ot1wi3xi 258 3 these these DT cord-016990-ot1wi3xi 258 4 infected infected JJ cord-016990-ot1wi3xi 258 5 cells cell NNS cord-016990-ot1wi3xi 258 6 slough slough VBP cord-016990-ot1wi3xi 258 7 from from IN cord-016990-ot1wi3xi 258 8 the the DT cord-016990-ot1wi3xi 258 9 epithelium epithelium NN cord-016990-ot1wi3xi 258 10 and and CC cord-016990-ot1wi3xi 258 11 can can MD cord-016990-ot1wi3xi 258 12 be be VB cord-016990-ot1wi3xi 258 13 observed observe VBN cord-016990-ot1wi3xi 258 14 by by IN cord-016990-ot1wi3xi 258 15 using use VBG cord-016990-ot1wi3xi 258 16 ISH ISH NNP cord-016990-ot1wi3xi 258 17 within within IN cord-016990-ot1wi3xi 258 18 the the DT cord-016990-ot1wi3xi 258 19 bronchial bronchial JJ cord-016990-ot1wi3xi 258 20 lumen lumen NN cord-016990-ot1wi3xi 258 21 . . . cord-016990-ot1wi3xi 259 1 Abundant abundant JJ cord-016990-ot1wi3xi 259 2 viral viral JJ cord-016990-ot1wi3xi 259 3 antigens antigen NNS cord-016990-ot1wi3xi 259 4 can can MD cord-016990-ot1wi3xi 259 5 also also RB cord-016990-ot1wi3xi 259 6 be be VB cord-016990-ot1wi3xi 259 7 found find VBN cord-016990-ot1wi3xi 259 8 distributed distribute VBN cord-016990-ot1wi3xi 259 9 focally focally RB cord-016990-ot1wi3xi 259 10 in in IN cord-016990-ot1wi3xi 259 11 parenchyma parenchyma NN cord-016990-ot1wi3xi 259 12 of of IN cord-016990-ot1wi3xi 259 13 lungs lung NNS cord-016990-ot1wi3xi 259 14 of of IN cord-016990-ot1wi3xi 259 15 some some DT cord-016990-ot1wi3xi 259 16 patients patient NNS cord-016990-ot1wi3xi 259 17 and and CC cord-016990-ot1wi3xi 259 18 are be VBP cord-016990-ot1wi3xi 259 19 seen see VBN cord-016990-ot1wi3xi 259 20 predominantly predominantly RB cord-016990-ot1wi3xi 259 21 in in IN cord-016990-ot1wi3xi 259 22 the the DT cord-016990-ot1wi3xi 259 23 cytoplasm cytoplasm NN cord-016990-ot1wi3xi 259 24 of of IN cord-016990-ot1wi3xi 259 25 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 259 26 , , , cord-016990-ot1wi3xi 259 27 in in IN cord-016990-ot1wi3xi 259 28 occasional occasional JJ cord-016990-ot1wi3xi 259 29 macrophages macrophage NNS cord-016990-ot1wi3xi 259 30 , , , cord-016990-ot1wi3xi 259 31 and and CC cord-016990-ot1wi3xi 259 32 in in IN cord-016990-ot1wi3xi 259 33 association association NN cord-016990-ot1wi3xi 259 34 with with IN cord-016990-ot1wi3xi 259 35 intra intra JJ cord-016990-ot1wi3xi 259 36 alveolar alveolar JJ cord-016990-ot1wi3xi 259 37 necrotic necrotic JJ cord-016990-ot1wi3xi 259 38 debris debris NN cord-016990-ot1wi3xi 259 39 and and CC cord-016990-ot1wi3xi 259 40 fibrin fibrin NN cord-016990-ot1wi3xi 259 41 ( ( -LRB- cord-016990-ot1wi3xi 259 42 Fig Fig NNP cord-016990-ot1wi3xi 259 43 . . . cord-016990-ot1wi3xi 259 44 ll.4D ll.4d CD cord-016990-ot1wi3xi 259 45 ) ) -RRB- cord-016990-ot1wi3xi 259 46 . . . cord-016990-ot1wi3xi 260 1 Double double JJ cord-016990-ot1wi3xi 260 2 - - HYPH cord-016990-ot1wi3xi 260 3 stain stain NN cord-016990-ot1wi3xi 260 4 studies study NNS cord-016990-ot1wi3xi 260 5 indicate indicate VBP cord-016990-ot1wi3xi 260 6 that that IN cord-016990-ot1wi3xi 260 7 most most JJS cord-016990-ot1wi3xi 260 8 SARS SARS NNP cord-016990-ot1wi3xi 260 9 - - HYPH cord-016990-ot1wi3xi 260 10 Co Co NNP cord-016990-ot1wi3xi 260 11 V v NN cord-016990-ot1wi3xi 260 12 - - HYPH cord-016990-ot1wi3xi 260 13 infected infect VBN cord-016990-ot1wi3xi 260 14 cells cell NNS cord-016990-ot1wi3xi 260 15 are be VBP cord-016990-ot1wi3xi 260 16 type type NN cord-016990-ot1wi3xi 260 17 2 2 CD cord-016990-ot1wi3xi 260 18 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 260 19 . . . cord-016990-ot1wi3xi 261 1 Double double JJ cord-016990-ot1wi3xi 261 2 - - HYPH cord-016990-ot1wi3xi 261 3 stain stain NN cord-016990-ot1wi3xi 261 4 studies study NNS cord-016990-ot1wi3xi 261 5 also also RB cord-016990-ot1wi3xi 261 6 detected detect VBD cord-016990-ot1wi3xi 261 7 viral viral JJ cord-016990-ot1wi3xi 261 8 nucleic nucleic JJ cord-016990-ot1wi3xi 261 9 acids acid NNS cord-016990-ot1wi3xi 261 10 with with IN cord-016990-ot1wi3xi 261 11 a a DT cord-016990-ot1wi3xi 261 12 distribution distribution NN cord-016990-ot1wi3xi 261 13 similar similar JJ cord-016990-ot1wi3xi 261 14 to to IN cord-016990-ot1wi3xi 261 15 that that DT cord-016990-ot1wi3xi 261 16 seen see VBN cord-016990-ot1wi3xi 261 17 in in IN cord-016990-ot1wi3xi 261 18 IHC IHC NNP cord-016990-ot1wi3xi 261 19 studies study NNS cord-016990-ot1wi3xi 261 20 , , , cord-016990-ot1wi3xi 261 21 mainly mainly RB cord-016990-ot1wi3xi 261 22 in in IN cord-016990-ot1wi3xi 261 23 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 261 24 and and CC cord-016990-ot1wi3xi 261 25 in in IN cord-016990-ot1wi3xi 261 26 some some DT cord-016990-ot1wi3xi 261 27 macrophages.lOoElectron macrophages.lOoElectron NNP cord-016990-ot1wi3xi 261 28 microscopic microscopic JJ cord-016990-ot1wi3xi 261 29 examination examination NN cord-016990-ot1wi3xi 261 30 of of IN cord-016990-ot1wi3xi 261 31 lung lung NN cord-016990-ot1wi3xi 261 32 tissues tissue NNS cord-016990-ot1wi3xi 261 33 selected select VBN cord-016990-ot1wi3xi 261 34 from from IN cord-016990-ot1wi3xi 261 35 areas area NNS cord-016990-ot1wi3xi 261 36 with with IN cord-016990-ot1wi3xi 261 37 abundant abundant JJ cord-016990-ot1wi3xi 261 38 IHC IHC NNP cord-016990-ot1wi3xi 261 39 staining staining NN cord-016990-ot1wi3xi 261 40 shows show VBZ cord-016990-ot1wi3xi 261 41 numerous numerous JJ cord-016990-ot1wi3xi 261 42 coronavirus coronavirus NN cord-016990-ot1wi3xi 261 43 particles particle NNS cord-016990-ot1wi3xi 261 44 and and CC cord-016990-ot1wi3xi 261 45 nucleocapsid nucleocapsid NN cord-016990-ot1wi3xi 261 46 inclusions inclusion NNS cord-016990-ot1wi3xi 261 47 . . . cord-016990-ot1wi3xi 262 1 Virions virion NNS cord-016990-ot1wi3xi 262 2 are be VBP cord-016990-ot1wi3xi 262 3 seen see VBN cord-016990-ot1wi3xi 262 4 in in IN cord-016990-ot1wi3xi 262 5 cytoplasmic cytoplasmic JJ cord-016990-ot1wi3xi 262 6 vesicles vesicle NNS cord-016990-ot1wi3xi 262 7 and and CC cord-016990-ot1wi3xi 262 8 along along IN cord-016990-ot1wi3xi 262 9 the the DT cord-016990-ot1wi3xi 262 10 cell cell NN cord-016990-ot1wi3xi 262 11 membranes membrane NNS cord-016990-ot1wi3xi 262 12 of of IN cord-016990-ot1wi3xi 262 13 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 262 14 , , , cord-016990-ot1wi3xi 262 15 in in IN cord-016990-ot1wi3xi 262 16 phagosomes phagosome NNS cord-016990-ot1wi3xi 262 17 of of IN cord-016990-ot1wi3xi 262 18 macrophages macrophage NNS cord-016990-ot1wi3xi 262 19 , , , cord-016990-ot1wi3xi 262 20 and and CC cord-016990-ot1wi3xi 262 21 associated associate VBN cord-016990-ot1wi3xi 262 22 with with IN cord-016990-ot1wi3xi 262 23 fibrin fibrin NN cord-016990-ot1wi3xi 262 24 in in IN cord-016990-ot1wi3xi 262 25 alveolar alveolar NN cord-016990-ot1wi3xi 262 26 spaces space NNS cord-016990-ot1wi3xi 262 27 ( ( -LRB- cord-016990-ot1wi3xi 262 28 Fig.ll.4G fig.ll.4g NN cord-016990-ot1wi3xi 262 29 - - HYPH cord-016990-ot1wi3xi 262 30 I I NNP cord-016990-ot1wi3xi 262 31 ) ) -RRB- cord-016990-ot1wi3xi 262 32 . . . cord-016990-ot1wi3xi 263 1 Because because IN cord-016990-ot1wi3xi 263 2 corona corona NN cord-016990-ot1wi3xi 263 3 virus virus NN cord-016990-ot1wi3xi 263 4 particles particle NNS cord-016990-ot1wi3xi 263 5 may may MD cord-016990-ot1wi3xi 263 6 be be VB cord-016990-ot1wi3xi 263 7 confused confuse VBN cord-016990-ot1wi3xi 263 8 morphologically morphologically RB cord-016990-ot1wi3xi 263 9 with with IN cord-016990-ot1wi3xi 263 10 other other JJ cord-016990-ot1wi3xi 263 11 non non JJ cord-016990-ot1wi3xi 263 12 viral viral JJ cord-016990-ot1wi3xi 263 13 cellular cellular JJ cord-016990-ot1wi3xi 263 14 components component NNS cord-016990-ot1wi3xi 263 15 , , , cord-016990-ot1wi3xi 263 16 definitive definitive JJ cord-016990-ot1wi3xi 263 17 ultrastructural ultrastructural JJ cord-016990-ot1wi3xi 263 18 identification identification NN cord-016990-ot1wi3xi 263 19 can can MD cord-016990-ot1wi3xi 263 20 be be VB cord-016990-ot1wi3xi 263 21 achieved achieve VBN cord-016990-ot1wi3xi 263 22 by by IN cord-016990-ot1wi3xi 263 23 using use VBG cord-016990-ot1wi3xi 263 24 immunogold immunogold JJ cord-016990-ot1wi3xi 263 25 labeling labeling NN cord-016990-ot1wi3xi 263 26 electron electron NN cord-016990-ot1wi3xi 263 27 microscopy microscopy NN cord-016990-ot1wi3xi 263 28 . . . cord-016990-ot1wi3xi 264 1 The the DT cord-016990-ot1wi3xi 264 2 primary primary JJ cord-016990-ot1wi3xi 264 3 histopathologic histopathologic JJ cord-016990-ot1wi3xi 264 4 lesions lesion NNS cord-016990-ot1wi3xi 264 5 seen see VBN cord-016990-ot1wi3xi 264 6 in in IN cord-016990-ot1wi3xi 264 7 the the DT cord-016990-ot1wi3xi 264 8 lungs lung NNS cord-016990-ot1wi3xi 264 9 of of IN cord-016990-ot1wi3xi 264 10 patients patient NNS cord-016990-ot1wi3xi 264 11 who who WP cord-016990-ot1wi3xi 264 12 die die VBP cord-016990-ot1wi3xi 264 13 from from IN cord-016990-ot1wi3xi 264 14 SARS SARS NNP cord-016990-ot1wi3xi 264 15 are be VBP cord-016990-ot1wi3xi 264 16 somewhat somewhat RB cord-016990-ot1wi3xi 264 17 nonspecific nonspecific JJ cord-016990-ot1wi3xi 264 18 and and CC cord-016990-ot1wi3xi 264 19 can can MD cord-016990-ot1wi3xi 264 20 also also RB cord-016990-ot1wi3xi 264 21 be be VB cord-016990-ot1wi3xi 264 22 seen see VBN cord-016990-ot1wi3xi 264 23 in in IN cord-016990-ot1wi3xi 264 24 acute acute JJ cord-016990-ot1wi3xi 264 25 lung lung NN cord-016990-ot1wi3xi 264 26 injury injury NN cord-016990-ot1wi3xi 264 27 cases case NNS cord-016990-ot1wi3xi 264 28 caused cause VBN cord-016990-ot1wi3xi 264 29 by by IN cord-016990-ot1wi3xi 264 30 infectious infectious JJ cord-016990-ot1wi3xi 264 31 agents agent NNS cord-016990-ot1wi3xi 264 32 , , , cord-016990-ot1wi3xi 264 33 trauma trauma NN cord-016990-ot1wi3xi 264 34 , , , cord-016990-ot1wi3xi 264 35 drugs drug NNS cord-016990-ot1wi3xi 264 36 , , , cord-016990-ot1wi3xi 264 37 or or CC cord-016990-ot1wi3xi 264 38 toxic toxic JJ cord-016990-ot1wi3xi 264 39 chemicals chemical NNS cord-016990-ot1wi3xi 264 40 . . . cord-016990-ot1wi3xi 265 1 102 102 CD cord-016990-ot1wi3xi 265 2 Multinucleated multinucleated JJ cord-016990-ot1wi3xi 265 3 syncytial syncytial JJ cord-016990-ot1wi3xi 265 4 cells cell NNS cord-016990-ot1wi3xi 265 5 similar similar JJ cord-016990-ot1wi3xi 265 6 to to IN cord-016990-ot1wi3xi 265 7 those those DT cord-016990-ot1wi3xi 265 8 seen see VBN cord-016990-ot1wi3xi 265 9 in in IN cord-016990-ot1wi3xi 265 10 some some DT cord-016990-ot1wi3xi 265 11 SARS SARS NNP cord-016990-ot1wi3xi 265 12 patients patient NNS cord-016990-ot1wi3xi 265 13 can can MD cord-016990-ot1wi3xi 265 14 also also RB cord-016990-ot1wi3xi 265 15 be be VB cord-016990-ot1wi3xi 265 16 found find VBN cord-016990-ot1wi3xi 265 17 in in IN cord-016990-ot1wi3xi 265 18 a a DT cord-016990-ot1wi3xi 265 19 number number NN cord-016990-ot1wi3xi 265 20 of of IN cord-016990-ot1wi3xi 265 21 virus virus NN cord-016990-ot1wi3xi 265 22 infections infection NNS cord-016990-ot1wi3xi 265 23 , , , cord-016990-ot1wi3xi 265 24 including include VBG cord-016990-ot1wi3xi 265 25 measles measle NNS cord-016990-ot1wi3xi 265 26 , , , cord-016990-ot1wi3xi 265 27 parainfluenza parainfluenza NNP cord-016990-ot1wi3xi 265 28 viruses virus NNS cord-016990-ot1wi3xi 265 29 , , , cord-016990-ot1wi3xi 265 30 RSV RSV NNP cord-016990-ot1wi3xi 265 31 , , , cord-016990-ot1wi3xi 265 32 and and CC cord-016990-ot1wi3xi 265 33 Nipah Nipah NNP cord-016990-ot1wi3xi 265 34 virus virus NN cord-016990-ot1wi3xi 265 35 infections infection NNS cord-016990-ot1wi3xi 265 36 . . . cord-016990-ot1wi3xi 266 1 102 102 CD cord-016990-ot1wi3xi 267 1 -104 -104 NN cord-016990-ot1wi3xi 268 1 In in IN cord-016990-ot1wi3xi 268 2 an an DT cord-016990-ot1wi3xi 268 3 early early JJ cord-016990-ot1wi3xi 268 4 study study NN cord-016990-ot1wi3xi 268 5 of of IN cord-016990-ot1wi3xi 268 6 four four CD cord-016990-ot1wi3xi 268 7 human human JJ cord-016990-ot1wi3xi 268 8 SARS SARS NNP cord-016990-ot1wi3xi 268 9 patients,13 patients,13 NNP cord-016990-ot1wi3xi 268 10 viral viral JJ cord-016990-ot1wi3xi 268 11 antigens antigen NNS cord-016990-ot1wi3xi 268 12 were be VBD cord-016990-ot1wi3xi 268 13 not not RB cord-016990-ot1wi3xi 268 14 detected detect VBN cord-016990-ot1wi3xi 268 15 in in IN cord-016990-ot1wi3xi 268 16 the the DT cord-016990-ot1wi3xi 268 17 lung lung NN cord-016990-ot1wi3xi 268 18 by by IN cord-016990-ot1wi3xi 268 19 IHe ihe PRP cord-016990-ot1wi3xi 268 20 . . . cord-016990-ot1wi3xi 269 1 The the DT cord-016990-ot1wi3xi 269 2 most most RBS cord-016990-ot1wi3xi 269 3 likely likely JJ cord-016990-ot1wi3xi 269 4 explanation explanation NN cord-016990-ot1wi3xi 269 5 is be VBZ cord-016990-ot1wi3xi 269 6 that that IN cord-016990-ot1wi3xi 269 7 all all DT cord-016990-ot1wi3xi 269 8 patients patient NNS cord-016990-ot1wi3xi 269 9 in in IN cord-016990-ot1wi3xi 269 10 the the DT cord-016990-ot1wi3xi 269 11 study study NN cord-016990-ot1wi3xi 269 12 had have VBD cord-016990-ot1wi3xi 269 13 a a DT cord-016990-ot1wi3xi 269 14 clinical clinical JJ cord-016990-ot1wi3xi 269 15 course course NN cord-016990-ot1wi3xi 269 16 aver aver NNP cord-016990-ot1wi3xi 269 17 - - HYPH cord-016990-ot1wi3xi 269 18 S.R. S.R. NNP cord-016990-ot1wi3xi 269 19 Zaki Zaki NNP cord-016990-ot1wi3xi 269 20 and and CC cord-016990-ot1wi3xi 269 21 CD CD NNP cord-016990-ot1wi3xi 269 22 . . . cord-016990-ot1wi3xi 270 1 Paddock paddock NN cord-016990-ot1wi3xi 270 2 aging age VBG cord-016990-ot1wi3xi 270 3 more more JJR cord-016990-ot1wi3xi 270 4 than than IN cord-016990-ot1wi3xi 270 5 2 2 CD cord-016990-ot1wi3xi 270 6 weeks week NNS cord-016990-ot1wi3xi 270 7 . . . cord-016990-ot1wi3xi 271 1 For for IN cord-016990-ot1wi3xi 271 2 many many JJ cord-016990-ot1wi3xi 271 3 virus virus NN cord-016990-ot1wi3xi 271 4 infections infection NNS cord-016990-ot1wi3xi 271 5 , , , cord-016990-ot1wi3xi 271 6 viral viral JJ cord-016990-ot1wi3xi 271 7 antigens antigen NNS cord-016990-ot1wi3xi 271 8 and and CC cord-016990-ot1wi3xi 271 9 nucleic nucleic JJ cord-016990-ot1wi3xi 271 10 acids acid NNS cord-016990-ot1wi3xi 271 11 are be VBP cord-016990-ot1wi3xi 271 12 cleared clear VBN cord-016990-ot1wi3xi 271 13 within within IN cord-016990-ot1wi3xi 271 14 2 2 CD cord-016990-ot1wi3xi 271 15 weeks week NNS cord-016990-ot1wi3xi 271 16 of of IN cord-016990-ot1wi3xi 271 17 disease disease NN cord-016990-ot1wi3xi 271 18 onset onset NN cord-016990-ot1wi3xi 271 19 by by IN cord-016990-ot1wi3xi 271 20 the the DT cord-016990-ot1wi3xi 271 21 host host NN cord-016990-ot1wi3xi 271 22 immune immune JJ cord-016990-ot1wi3xi 271 23 response response NN cord-016990-ot1wi3xi 271 24 . . . cord-016990-ot1wi3xi 272 1 It -PRON- PRP cord-016990-ot1wi3xi 272 2 is be VBZ cord-016990-ot1wi3xi 272 3 also also RB cord-016990-ot1wi3xi 272 4 possible possible JJ cord-016990-ot1wi3xi 272 5 that that IN cord-016990-ot1wi3xi 272 6 the the DT cord-016990-ot1wi3xi 272 7 pulmonary pulmonary JJ cord-016990-ot1wi3xi 272 8 damage damage NN cord-016990-ot1wi3xi 272 9 associated associate VBN cord-016990-ot1wi3xi 272 10 with with IN cord-016990-ot1wi3xi 272 11 SARS SARS NNP cord-016990-ot1wi3xi 272 12 is be VBZ cord-016990-ot1wi3xi 272 13 not not RB cord-016990-ot1wi3xi 272 14 caused cause VBN cord-016990-ot1wi3xi 272 15 directly directly RB cord-016990-ot1wi3xi 272 16 by by IN cord-016990-ot1wi3xi 272 17 the the DT cord-016990-ot1wi3xi 272 18 virus virus NN cord-016990-ot1wi3xi 272 19 , , , cord-016990-ot1wi3xi 272 20 but but CC cord-016990-ot1wi3xi 272 21 represents represent VBZ cord-016990-ot1wi3xi 272 22 a a DT cord-016990-ot1wi3xi 272 23 secondary secondary JJ cord-016990-ot1wi3xi 272 24 effect effect NN cord-016990-ot1wi3xi 272 25 of of IN cord-016990-ot1wi3xi 272 26 cytokines cytokine NNS cord-016990-ot1wi3xi 272 27 or or CC cord-016990-ot1wi3xi 272 28 other other JJ cord-016990-ot1wi3xi 272 29 factors factor NNS cord-016990-ot1wi3xi 272 30 induced induce VBN cord-016990-ot1wi3xi 272 31 by by IN cord-016990-ot1wi3xi 272 32 the the DT cord-016990-ot1wi3xi 272 33 virus virus NN cord-016990-ot1wi3xi 272 34 infection infection NN cord-016990-ot1wi3xi 272 35 . . . cord-016990-ot1wi3xi 273 1 Similarly similarly RB cord-016990-ot1wi3xi 273 2 , , , cord-016990-ot1wi3xi 273 3 in in IN cord-016990-ot1wi3xi 273 4 influenza influenza NN cord-016990-ot1wi3xi 273 5 virus virus NN cord-016990-ot1wi3xi 273 6 infections infection NNS cord-016990-ot1wi3xi 273 7 , , , cord-016990-ot1wi3xi 273 8 viral viral JJ cord-016990-ot1wi3xi 273 9 antigens antigen NNS cord-016990-ot1wi3xi 273 10 are be VBP cord-016990-ot1wi3xi 273 11 seen see VBN cord-016990-ot1wi3xi 273 12 predominantly predominantly RB cord-016990-ot1wi3xi 273 13 in in IN cord-016990-ot1wi3xi 273 14 respiratory respiratory JJ cord-016990-ot1wi3xi 273 15 epithelial epithelial JJ cord-016990-ot1wi3xi 273 16 cells cell NNS cord-016990-ot1wi3xi 273 17 of of IN cord-016990-ot1wi3xi 273 18 large large JJ cord-016990-ot1wi3xi 273 19 airways airway NNS cord-016990-ot1wi3xi 273 20 and and CC cord-016990-ot1wi3xi 273 21 are be VBP cord-016990-ot1wi3xi 273 22 only only RB cord-016990-ot1wi3xi 273 23 rarely rarely RB cord-016990-ot1wi3xi 273 24 identified identify VBN cord-016990-ot1wi3xi 273 25 in in IN cord-016990-ot1wi3xi 273 26 pulmonary pulmonary JJ cord-016990-ot1wi3xi 273 27 parenchyma parenchyma NN cord-016990-ot1wi3xi 273 28 despite despite IN cord-016990-ot1wi3xi 273 29 concomitant concomitant JJ cord-016990-ot1wi3xi 273 30 and and CC cord-016990-ot1wi3xi 273 31 occasionally occasionally RB cord-016990-ot1wi3xi 273 32 severe severe JJ cord-016990-ot1wi3xi 273 33 interstitial interstitial JJ cord-016990-ot1wi3xi 273 34 pneumonitis pneumonitis NN cord-016990-ot1wi3xi 273 35 . . . cord-016990-ot1wi3xi 273 36 ! ! . cord-016990-ot1wi3xi 274 1 Os Os NNP cord-016990-ot1wi3xi 275 1 In in IN cord-016990-ot1wi3xi 275 2 recent recent JJ cord-016990-ot1wi3xi 275 3 reports report NNS cord-016990-ot1wi3xi 275 4 by by IN cord-016990-ot1wi3xi 275 5 Shieh Shieh NNP cord-016990-ot1wi3xi 275 6 et et NNP cord-016990-ot1wi3xi 275 7 al al NNP cord-016990-ot1wi3xi 275 8 . . . cord-016990-ot1wi3xi 276 1 100 100 CD cord-016990-ot1wi3xi 276 2 and and CC cord-016990-ot1wi3xi 276 3 Chong Chong NNP cord-016990-ot1wi3xi 276 4 et et NNP cord-016990-ot1wi3xi 276 5 al al NNP cord-016990-ot1wi3xi 276 6 . . . cord-016990-ot1wi3xi 277 1 , , , cord-016990-ot1wi3xi 277 2 92 92 CD cord-016990-ot1wi3xi 277 3 the the DT cord-016990-ot1wi3xi 277 4 temporal temporal JJ cord-016990-ot1wi3xi 277 5 relationship relationship NN cord-016990-ot1wi3xi 277 6 between between IN cord-016990-ot1wi3xi 277 7 the the DT cord-016990-ot1wi3xi 277 8 duration duration NN cord-016990-ot1wi3xi 277 9 of of IN cord-016990-ot1wi3xi 277 10 illness illness NN cord-016990-ot1wi3xi 277 11 and and CC cord-016990-ot1wi3xi 277 12 clearance clearance NN cord-016990-ot1wi3xi 277 13 of of IN cord-016990-ot1wi3xi 277 14 SARS SARS NNP cord-016990-ot1wi3xi 277 15 - - HYPH cord-016990-ot1wi3xi 277 16 Co Co NNP cord-016990-ot1wi3xi 277 17 V v NN cord-016990-ot1wi3xi 277 18 in in IN cord-016990-ot1wi3xi 277 19 human human JJ cord-016990-ot1wi3xi 277 20 lung lung NN cord-016990-ot1wi3xi 277 21 tissue tissue NN cord-016990-ot1wi3xi 277 22 was be VBD cord-016990-ot1wi3xi 277 23 examined examine VBN cord-016990-ot1wi3xi 277 24 . . . cord-016990-ot1wi3xi 278 1 Viral viral JJ cord-016990-ot1wi3xi 278 2 antigens antigen NNS cord-016990-ot1wi3xi 278 3 and and CC cord-016990-ot1wi3xi 278 4 nucleic nucleic JJ cord-016990-ot1wi3xi 278 5 acids acid NNS cord-016990-ot1wi3xi 278 6 were be VBD cord-016990-ot1wi3xi 278 7 detected detect VBN cord-016990-ot1wi3xi 278 8 only only RB cord-016990-ot1wi3xi 278 9 in in IN cord-016990-ot1wi3xi 278 10 pulmonary pulmonary JJ cord-016990-ot1wi3xi 278 11 tissues tissue NNS cord-016990-ot1wi3xi 278 12 of of IN cord-016990-ot1wi3xi 278 13 patients patient NNS cord-016990-ot1wi3xi 278 14 who who WP cord-016990-ot1wi3xi 278 15 died die VBD cord-016990-ot1wi3xi 278 16 early early RB cord-016990-ot1wi3xi 278 17 in in IN cord-016990-ot1wi3xi 278 18 the the DT cord-016990-ot1wi3xi 278 19 disease disease NN cord-016990-ot1wi3xi 278 20 . . . cord-016990-ot1wi3xi 279 1 The the DT cord-016990-ot1wi3xi 279 2 development development NN cord-016990-ot1wi3xi 279 3 of of IN cord-016990-ot1wi3xi 279 4 specific specific JJ cord-016990-ot1wi3xi 279 5 IHC IHC NNP cord-016990-ot1wi3xi 279 6 , , , cord-016990-ot1wi3xi 279 7 ISH ISH NNP cord-016990-ot1wi3xi 279 8 , , , cord-016990-ot1wi3xi 279 9 and and CC cord-016990-ot1wi3xi 279 10 immunoelectron immunoelectron NNP cord-016990-ot1wi3xi 279 11 microscopy microscopy NNP cord-016990-ot1wi3xi 279 12 ( ( -LRB- cord-016990-ot1wi3xi 279 13 IEM IEM NNP cord-016990-ot1wi3xi 279 14 ) ) -RRB- cord-016990-ot1wi3xi 279 15 assays assay NNS cord-016990-ot1wi3xi 279 16 to to TO cord-016990-ot1wi3xi 279 17 identify identify VB cord-016990-ot1wi3xi 279 18 SARS SARS NNP cord-016990-ot1wi3xi 279 19 - - HYPH cord-016990-ot1wi3xi 279 20 Co Co NNP cord-016990-ot1wi3xi 279 21 V v NN cord-016990-ot1wi3xi 279 22 in in IN cord-016990-ot1wi3xi 279 23 formalin formalin NN cord-016990-ot1wi3xi 279 24 - - HYPH cord-016990-ot1wi3xi 279 25 fixed fix VBN cord-016990-ot1wi3xi 279 26 , , , cord-016990-ot1wi3xi 279 27 paraffin paraffin NN cord-016990-ot1wi3xi 279 28 - - HYPH cord-016990-ot1wi3xi 279 29 embedded embed VBN cord-016990-ot1wi3xi 279 30 samples sample NNS cord-016990-ot1wi3xi 279 31 has have VBZ cord-016990-ot1wi3xi 279 32 facilitated facilitate VBN cord-016990-ot1wi3xi 279 33 the the DT cord-016990-ot1wi3xi 279 34 assessment assessment NN cord-016990-ot1wi3xi 279 35 of of IN cord-016990-ot1wi3xi 279 36 the the DT cord-016990-ot1wi3xi 279 37 cellular cellular JJ cord-016990-ot1wi3xi 279 38 tropism tropism NN cord-016990-ot1wi3xi 279 39 of of IN cord-016990-ot1wi3xi 279 40 SARS SARS NNP cord-016990-ot1wi3xi 279 41 - - HYPH cord-016990-ot1wi3xi 279 42 Co Co NNP cord-016990-ot1wi3xi 279 43 V v NN cord-016990-ot1wi3xi 279 44 infection infection NN cord-016990-ot1wi3xi 279 45 in in IN cord-016990-ot1wi3xi 279 46 human human JJ cord-016990-ot1wi3xi 279 47 lung lung NN cord-016990-ot1wi3xi 279 48 tissues tissue NNS cord-016990-ot1wi3xi 279 49 . . . cord-016990-ot1wi3xi 280 1 Localization localization NN cord-016990-ot1wi3xi 280 2 of of IN cord-016990-ot1wi3xi 280 3 SARS SARS NNP cord-016990-ot1wi3xi 280 4 - - HYPH cord-016990-ot1wi3xi 280 5 Co Co NNP cord-016990-ot1wi3xi 280 6 V v NN cord-016990-ot1wi3xi 280 7 in in IN cord-016990-ot1wi3xi 280 8 the the DT cord-016990-ot1wi3xi 280 9 lung lung NN cord-016990-ot1wi3xi 280 10 occurs occur VBZ cord-016990-ot1wi3xi 280 11 mainly mainly RB cord-016990-ot1wi3xi 280 12 in in IN cord-016990-ot1wi3xi 280 13 the the DT cord-016990-ot1wi3xi 280 14 cytoplasm cytoplasm NN cord-016990-ot1wi3xi 280 15 of of IN cord-016990-ot1wi3xi 280 16 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 280 17 , , , cord-016990-ot1wi3xi 280 18 primarily primarily RB cord-016990-ot1wi3xi 280 19 type type NN cord-016990-ot1wi3xi 280 20 2 2 CD cord-016990-ot1wi3xi 280 21 , , , cord-016990-ot1wi3xi 280 22 and and CC cord-016990-ot1wi3xi 280 23 occasionally occasionally RB cord-016990-ot1wi3xi 280 24 in in IN cord-016990-ot1wi3xi 280 25 alveolar alveolar JJ cord-016990-ot1wi3xi 280 26 macrophages macrophage NNS cord-016990-ot1wi3xi 280 27 ( ( -LRB- cord-016990-ot1wi3xi 280 28 Fig Fig NNP cord-016990-ot1wi3xi 280 29 . . . cord-016990-ot1wi3xi 280 30 ll.4F ll.4F NFP cord-016990-ot1wi3xi 280 31 ) ) -RRB- cord-016990-ot1wi3xi 280 32 . . . cord-016990-ot1wi3xi 281 1 Type type NN cord-016990-ot1wi3xi 281 2 2 2 CD cord-016990-ot1wi3xi 281 3 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 281 4 are be VBP cord-016990-ot1wi3xi 281 5 known know VBN cord-016990-ot1wi3xi 281 6 to to TO cord-016990-ot1wi3xi 281 7 secrete secrete VB cord-016990-ot1wi3xi 281 8 pulmonary pulmonary JJ cord-016990-ot1wi3xi 281 9 surfactant surfactant NN cord-016990-ot1wi3xi 281 10 , , , cord-016990-ot1wi3xi 281 11 resulting result VBG cord-016990-ot1wi3xi 281 12 in in IN cord-016990-ot1wi3xi 281 13 reduced reduce VBN cord-016990-ot1wi3xi 281 14 surface surface NN cord-016990-ot1wi3xi 281 15 tension tension NN cord-016990-ot1wi3xi 281 16 and and CC cord-016990-ot1wi3xi 281 17 preservation preservation NN cord-016990-ot1wi3xi 281 18 of of IN cord-016990-ot1wi3xi 281 19 the the DT cord-016990-ot1wi3xi 281 20 integrity integrity NN cord-016990-ot1wi3xi 281 21 of of IN cord-016990-ot1wi3xi 281 22 the the DT cord-016990-ot1wi3xi 281 23 alveolar alveolar JJ cord-016990-ot1wi3xi 281 24 space space NN cord-016990-ot1wi3xi 281 25 . . . cord-016990-ot1wi3xi 282 1 These these DT cord-016990-ot1wi3xi 282 2 cells cell NNS cord-016990-ot1wi3xi 282 3 also also RB cord-016990-ot1wi3xi 282 4 play play VBP cord-016990-ot1wi3xi 282 5 an an DT cord-016990-ot1wi3xi 282 6 important important JJ cord-016990-ot1wi3xi 282 7 role role NN cord-016990-ot1wi3xi 282 8 in in IN cord-016990-ot1wi3xi 282 9 tissue tissue NN cord-016990-ot1wi3xi 282 10 restitution restitution NN cord-016990-ot1wi3xi 282 11 following follow VBG cord-016990-ot1wi3xi 282 12 lung lung NN cord-016990-ot1wi3xi 282 13 damage damage NN cord-016990-ot1wi3xi 282 14 . . . cord-016990-ot1wi3xi 283 1 Moreover moreover RB cord-016990-ot1wi3xi 283 2 , , , cord-016990-ot1wi3xi 283 3 there there EX cord-016990-ot1wi3xi 283 4 is be VBZ cord-016990-ot1wi3xi 283 5 mounting mount VBG cord-016990-ot1wi3xi 283 6 evidence evidence NN cord-016990-ot1wi3xi 283 7 to to TO cord-016990-ot1wi3xi 283 8 support support VB cord-016990-ot1wi3xi 283 9 their -PRON- PRP$ cord-016990-ot1wi3xi 283 10 contribution contribution NN cord-016990-ot1wi3xi 283 11 to to IN cord-016990-ot1wi3xi 283 12 the the DT cord-016990-ot1wi3xi 283 13 development development NN cord-016990-ot1wi3xi 283 14 of of IN cord-016990-ot1wi3xi 283 15 acute acute JJ cord-016990-ot1wi3xi 283 16 inflammatory inflammatory JJ cord-016990-ot1wi3xi 283 17 lung lung NN cord-016990-ot1wi3xi 283 18 injury injury NN cord-016990-ot1wi3xi 283 19 following follow VBG cord-016990-ot1wi3xi 283 20 exposure exposure NN cord-016990-ot1wi3xi 283 21 to to IN cord-016990-ot1wi3xi 283 22 biological biological JJ cord-016990-ot1wi3xi 283 23 or or CC cord-016990-ot1wi3xi 283 24 chemical chemical JJ cord-016990-ot1wi3xi 283 25 agents agent NNS cord-016990-ot1wi3xi 283 26 . . . cord-016990-ot1wi3xi 284 1 Additional additional JJ cord-016990-ot1wi3xi 284 2 studies study NNS cord-016990-ot1wi3xi 284 3 are be VBP cord-016990-ot1wi3xi 284 4 needed need VBN cord-016990-ot1wi3xi 284 5 to to TO cord-016990-ot1wi3xi 284 6 further further RB cord-016990-ot1wi3xi 284 7 define define VB cord-016990-ot1wi3xi 284 8 the the DT cord-016990-ot1wi3xi 284 9 role role NN cord-016990-ot1wi3xi 284 10 of of IN cord-016990-ot1wi3xi 284 11 type type NN cord-016990-ot1wi3xi 284 12 2 2 CD cord-016990-ot1wi3xi 284 13 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 284 14 and and CC cord-016990-ot1wi3xi 284 15 alveolar alveolar JJ cord-016990-ot1wi3xi 284 16 macrophages macrophage NNS cord-016990-ot1wi3xi 284 17 in in IN cord-016990-ot1wi3xi 284 18 SARS SARS NNP cord-016990-ot1wi3xi 284 19 - - HYPH cord-016990-ot1wi3xi 284 20 Co Co NNP cord-016990-ot1wi3xi 284 21 V v NN cord-016990-ot1wi3xi 284 22 infection infection NN cord-016990-ot1wi3xi 284 23 . . . cord-016990-ot1wi3xi 285 1 Cynomolgus cynomolgus JJ cord-016990-ot1wi3xi 285 2 macaques macaque NNS cord-016990-ot1wi3xi 285 3 inoculated inoculate VBN cord-016990-ot1wi3xi 285 4 with with IN cord-016990-ot1wi3xi 285 5 SARS SARS NNP cord-016990-ot1wi3xi 285 6 - - HYPH cord-016990-ot1wi3xi 285 7 CoV CoV NNP cord-016990-ot1wi3xi 286 1 develop develop VB cord-016990-ot1wi3xi 286 2 pathologic pathologic JJ cord-016990-ot1wi3xi 286 3 findings finding NNS cord-016990-ot1wi3xi 286 4 of of IN cord-016990-ot1wi3xi 286 5 pneumonia pneumonia NN cord-016990-ot1wi3xi 286 6 and and CC cord-016990-ot1wi3xi 286 7 have have VBP cord-016990-ot1wi3xi 286 8 been be VBN cord-016990-ot1wi3xi 286 9 proposed propose VBN cord-016990-ot1wi3xi 286 10 as as IN cord-016990-ot1wi3xi 286 11 an an DT cord-016990-ot1wi3xi 286 12 animal animal NN cord-016990-ot1wi3xi 286 13 model model NN cord-016990-ot1wi3xi 286 14 . . . cord-016990-ot1wi3xi 287 1 106 106 CD cord-016990-ot1wi3xi 287 2 Haagmans Haagmans NNPS cord-016990-ot1wi3xi 287 3 et et NNP cord-016990-ot1wi3xi 287 4 a1 a1 NN cord-016990-ot1wi3xi 287 5 . . . cord-016990-ot1wi3xi 288 1 107 107 CD cord-016990-ot1wi3xi 288 2 showed show VBD cord-016990-ot1wi3xi 288 3 extensive extensive JJ cord-016990-ot1wi3xi 288 4 SARS SARS NNP cord-016990-ot1wi3xi 288 5 - - HYPH cord-016990-ot1wi3xi 288 6 Co Co NNP cord-016990-ot1wi3xi 288 7 V V NNP cord-016990-ot1wi3xi 288 8 antigen antigen NN cord-016990-ot1wi3xi 288 9 expression expression NN cord-016990-ot1wi3xi 288 10 in in IN cord-016990-ot1wi3xi 288 11 experimentally experimentally RB cord-016990-ot1wi3xi 288 12 infected infect VBN cord-016990-ot1wi3xi 288 13 macaques macaque NNS cord-016990-ot1wi3xi 288 14 4 4 CD cord-016990-ot1wi3xi 288 15 days day NNS cord-016990-ot1wi3xi 288 16 after after IN cord-016990-ot1wi3xi 288 17 infection infection NN cord-016990-ot1wi3xi 288 18 . . . cord-016990-ot1wi3xi 289 1 The the DT cord-016990-ot1wi3xi 289 2 antigens antigen NNS cord-016990-ot1wi3xi 289 3 were be VBD cord-016990-ot1wi3xi 289 4 mainly mainly RB cord-016990-ot1wi3xi 289 5 in in IN cord-016990-ot1wi3xi 289 6 alveolar alveolar JJ cord-016990-ot1wi3xi 289 7 lining line VBG cord-016990-ot1wi3xi 289 8 epithelial epithelial JJ cord-016990-ot1wi3xi 289 9 cells cell NNS cord-016990-ot1wi3xi 289 10 with with IN cord-016990-ot1wi3xi 289 11 morphologic morphologic JJ cord-016990-ot1wi3xi 289 12 characteristics characteristic NNS cord-016990-ot1wi3xi 289 13 of of IN cord-016990-ot1wi3xi 289 14 type type NN cord-016990-ot1wi3xi 289 15 1 1 CD cord-016990-ot1wi3xi 289 16 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 289 17 , , , cord-016990-ot1wi3xi 289 18 indicating indicate VBG cord-016990-ot1wi3xi 289 19 type type NN cord-016990-ot1wi3xi 289 20 1 1 CD cord-016990-ot1wi3xi 289 21 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 289 22 are be VBP cord-016990-ot1wi3xi 289 23 the the DT cord-016990-ot1wi3xi 289 24 primary primary JJ cord-016990-ot1wi3xi 289 25 target target NN cord-016990-ot1wi3xi 289 26 for for IN cord-016990-ot1wi3xi 289 27 SARS SARS NNP cord-016990-ot1wi3xi 289 28 - - HYPH cord-016990-ot1wi3xi 289 29 Co Co NNP cord-016990-ot1wi3xi 289 30 V v NN cord-016990-ot1wi3xi 289 31 infection infection NN cord-016990-ot1wi3xi 289 32 early early RB cord-016990-ot1wi3xi 289 33 in in IN cord-016990-ot1wi3xi 289 34 the the DT cord-016990-ot1wi3xi 289 35 disease disease NN cord-016990-ot1wi3xi 289 36 . . . cord-016990-ot1wi3xi 290 1 Type type NN cord-016990-ot1wi3xi 290 2 1 1 CD cord-016990-ot1wi3xi 290 3 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 290 4 normally normally RB cord-016990-ot1wi3xi 290 5 represent represent VBP cord-016990-ot1wi3xi 290 6 90 90 CD cord-016990-ot1wi3xi 290 7 % % NN cord-016990-ot1wi3xi 290 8 of of IN cord-016990-ot1wi3xi 290 9 the the DT cord-016990-ot1wi3xi 290 10 alveolar alveolar JJ cord-016990-ot1wi3xi 290 11 epithelial epithelial JJ cord-016990-ot1wi3xi 290 12 cell cell NN cord-016990-ot1wi3xi 290 13 volume volume NN cord-016990-ot1wi3xi 290 14 and and CC cord-016990-ot1wi3xi 290 15 are be VBP cord-016990-ot1wi3xi 290 16 easily easily RB cord-016990-ot1wi3xi 290 17 damaged damage VBN cord-016990-ot1wi3xi 290 18 during during IN cord-016990-ot1wi3xi 290 19 pulmonary pulmonary JJ cord-016990-ot1wi3xi 290 20 infections infection NNS cord-016990-ot1wi3xi 290 21 or or CC cord-016990-ot1wi3xi 290 22 other other JJ cord-016990-ot1wi3xi 290 23 types type NNS cord-016990-ot1wi3xi 290 24 of of IN cord-016990-ot1wi3xi 290 25 injury injury NN cord-016990-ot1wi3xi 290 26 . . . cord-016990-ot1wi3xi 291 1 In in IN cord-016990-ot1wi3xi 291 2 a a DT cord-016990-ot1wi3xi 291 3 more more RBR cord-016990-ot1wi3xi 291 4 recent recent JJ cord-016990-ot1wi3xi 291 5 study study NN cord-016990-ot1wi3xi 291 6 on on IN cord-016990-ot1wi3xi 291 7 nonhuman nonhuman NNS cord-016990-ot1wi3xi 291 8 primates,108 primates,108 NN cord-016990-ot1wi3xi 291 9 evidence evidence NN cord-016990-ot1wi3xi 291 10 of of IN cord-016990-ot1wi3xi 291 11 infection infection NN cord-016990-ot1wi3xi 291 12 of of IN cord-016990-ot1wi3xi 291 13 type type NN cord-016990-ot1wi3xi 291 14 1 1 CD cord-016990-ot1wi3xi 291 15 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 291 16 in in IN cord-016990-ot1wi3xi 291 17 addition addition NN cord-016990-ot1wi3xi 291 18 to to IN cord-016990-ot1wi3xi 291 19 some some DT cord-016990-ot1wi3xi 291 20 type type NN cord-016990-ot1wi3xi 291 21 2 2 CD cord-016990-ot1wi3xi 291 22 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 291 23 and and CC cord-016990-ot1wi3xi 291 24 macrophages macrophage NNS cord-016990-ot1wi3xi 291 25 was be VBD cord-016990-ot1wi3xi 291 26 found find VBN cord-016990-ot1wi3xi 291 27 . . . cord-016990-ot1wi3xi 292 1 Small small JJ cord-016990-ot1wi3xi 292 2 animal animal NN cord-016990-ot1wi3xi 292 3 models model NNS cord-016990-ot1wi3xi 292 4 , , , cord-016990-ot1wi3xi 292 5 such such JJ cord-016990-ot1wi3xi 292 6 as as IN cord-016990-ot1wi3xi 292 7 rodents rodent NNS cord-016990-ot1wi3xi 292 8 , , , cord-016990-ot1wi3xi 292 9 would would MD cord-016990-ot1wi3xi 292 10 be be VB cord-016990-ot1wi3xi 292 11 very very RB cord-016990-ot1wi3xi 292 12 useful useful JJ cord-016990-ot1wi3xi 292 13 for for IN cord-016990-ot1wi3xi 292 14 evaluating evaluate VBG cord-016990-ot1wi3xi 292 15 vaccines vaccine NNS cord-016990-ot1wi3xi 292 16 , , , cord-016990-ot1wi3xi 292 17 immunotherapies immunotherapy NNS cord-016990-ot1wi3xi 292 18 , , , cord-016990-ot1wi3xi 292 19 and and CC cord-016990-ot1wi3xi 292 20 antiviral antiviral JJ cord-016990-ot1wi3xi 292 21 drugs drug NNS cord-016990-ot1wi3xi 292 22 , , , cord-016990-ot1wi3xi 292 23 and and CC cord-016990-ot1wi3xi 292 24 we -PRON- PRP cord-016990-ot1wi3xi 292 25 have have VBP cord-016990-ot1wi3xi 292 26 recently recently RB cord-016990-ot1wi3xi 292 27 identified identify VBN cord-016990-ot1wi3xi 292 28 the the DT cord-016990-ot1wi3xi 292 29 mouse mouse NN cord-016990-ot1wi3xi 292 30 as as IN cord-016990-ot1wi3xi 292 31 an an DT cord-016990-ot1wi3xi 292 32 animal animal NN cord-016990-ot1wi3xi 292 33 model model NN cord-016990-ot1wi3xi 292 34 for for IN cord-016990-ot1wi3xi 292 35 this this DT cord-016990-ot1wi3xi 292 36 purpose purpose NN cord-016990-ot1wi3xi 292 37 . . . cord-016990-ot1wi3xi 293 1 10 10 CD cord-016990-ot1wi3xi 293 2 9 9 CD cord-016990-ot1wi3xi 294 1 In in IN cord-016990-ot1wi3xi 294 2 those those DT cord-016990-ot1wi3xi 294 3 studies study NNS cord-016990-ot1wi3xi 294 4 , , , cord-016990-ot1wi3xi 294 5 microscopic microscopic JJ cord-016990-ot1wi3xi 294 6 examination examination NN cord-016990-ot1wi3xi 294 7 of of IN cord-016990-ot1wi3xi 294 8 trachea trachea NN cord-016990-ot1wi3xi 294 9 , , , cord-016990-ot1wi3xi 294 10 bronchus bronchus NN cord-016990-ot1wi3xi 294 11 , , , cord-016990-ot1wi3xi 294 12 lung lung NN cord-016990-ot1wi3xi 294 13 , , , cord-016990-ot1wi3xi 294 14 thymus thymus NN cord-016990-ot1wi3xi 294 15 , , , cord-016990-ot1wi3xi 294 16 and and CC cord-016990-ot1wi3xi 294 17 heart heart NN cord-016990-ot1wi3xi 294 18 on on IN cord-016990-ot1wi3xi 294 19 day day NN cord-016990-ot1wi3xi 294 20 2 2 CD cord-016990-ot1wi3xi 294 21 after after IN cord-016990-ot1wi3xi 294 22 infection infection NN cord-016990-ot1wi3xi 294 23 revealed reveal VBD cord-016990-ot1wi3xi 294 24 mild mild JJ cord-016990-ot1wi3xi 294 25 and and CC cord-016990-ot1wi3xi 294 26 focal focal JJ cord-016990-ot1wi3xi 294 27 peri peri FW cord-016990-ot1wi3xi 294 28 bronchiolar bronchiolar JJ cord-016990-ot1wi3xi 294 29 mononuclear mononuclear JJ cord-016990-ot1wi3xi 294 30 inflammatory inflammatory JJ cord-016990-ot1wi3xi 294 31 infiltrates infiltrate VBZ cord-016990-ot1wi3xi 294 32 with with IN cord-016990-ot1wi3xi 294 33 no no DT cord-016990-ot1wi3xi 294 34 significant significant JJ cord-016990-ot1wi3xi 294 35 histopathologic histopathologic JJ cord-016990-ot1wi3xi 294 36 change change NN cord-016990-ot1wi3xi 294 37 in in IN cord-016990-ot1wi3xi 294 38 other other JJ cord-016990-ot1wi3xi 294 39 organs organ NNS cord-016990-ot1wi3xi 294 40 . . . cord-016990-ot1wi3xi 295 1 Viral viral JJ cord-016990-ot1wi3xi 295 2 antigens antigen NNS cord-016990-ot1wi3xi 295 3 and and CC cord-016990-ot1wi3xi 295 4 nucleic nucleic JJ cord-016990-ot1wi3xi 295 5 acids acid NNS cord-016990-ot1wi3xi 295 6 were be VBD cord-016990-ot1wi3xi 295 7 focally focally RB cord-016990-ot1wi3xi 295 8 distributed distribute VBN cord-016990-ot1wi3xi 295 9 in in IN cord-016990-ot1wi3xi 295 10 bronchiolar bronchiolar JJ cord-016990-ot1wi3xi 295 11 epithelial epithelial JJ cord-016990-ot1wi3xi 295 12 cells cell NNS cord-016990-ot1wi3xi 295 13 , , , cord-016990-ot1wi3xi 295 14 and and CC cord-016990-ot1wi3xi 295 15 virions virion NNS cord-016990-ot1wi3xi 295 16 were be VBD cord-016990-ot1wi3xi 295 17 found find VBN cord-016990-ot1wi3xi 295 18 in in IN cord-016990-ot1wi3xi 295 19 these these DT cord-016990-ot1wi3xi 295 20 same same JJ cord-016990-ot1wi3xi 295 21 areas area NNS cord-016990-ot1wi3xi 295 22 by by IN cord-016990-ot1wi3xi 295 23 ultrastructural ultrastructural JJ cord-016990-ot1wi3xi 295 24 analysis analysis NN cord-016990-ot1wi3xi 295 25 . . . cord-016990-ot1wi3xi 296 1 Data datum NNS cord-016990-ot1wi3xi 296 2 suggest suggest VBP cord-016990-ot1wi3xi 296 3 that that IN cord-016990-ot1wi3xi 296 4 SARS SARS NNP cord-016990-ot1wi3xi 296 5 - - HYPH cord-016990-ot1wi3xi 296 6 Co Co NNP cord-016990-ot1wi3xi 296 7 V V NNP cord-016990-ot1wi3xi 296 8 replicates replicate VBZ cord-016990-ot1wi3xi 296 9 in in IN cord-016990-ot1wi3xi 296 10 mice mouse NNS cord-016990-ot1wi3xi 296 11 to to IN cord-016990-ot1wi3xi 296 12 a a DT cord-016990-ot1wi3xi 296 13 titer titer NN cord-016990-ot1wi3xi 296 14 sufficient sufficient JJ cord-016990-ot1wi3xi 296 15 to to TO cord-016990-ot1wi3xi 296 16 evaluate evaluate VB cord-016990-ot1wi3xi 296 17 vaccines vaccine NNS cord-016990-ot1wi3xi 296 18 and and CC cord-016990-ot1wi3xi 296 19 antiviral antiviral JJ cord-016990-ot1wi3xi 296 20 agents agent NNS cord-016990-ot1wi3xi 296 21 . . . cord-016990-ot1wi3xi 297 1 The the DT cord-016990-ot1wi3xi 297 2 mouse mouse NN cord-016990-ot1wi3xi 297 3 and and CC cord-016990-ot1wi3xi 297 4 other other JJ cord-016990-ot1wi3xi 297 5 small small JJ cord-016990-ot1wi3xi 297 6 animal animal NN cord-016990-ot1wi3xi 297 7 models model NNS cord-016990-ot1wi3xi 297 8 l1O l1O NNP cord-016990-ot1wi3xi 297 9 might may MD cord-016990-ot1wi3xi 297 10 also also RB cord-016990-ot1wi3xi 297 11 be be VB cord-016990-ot1wi3xi 297 12 used use VBN cord-016990-ot1wi3xi 297 13 to to TO cord-016990-ot1wi3xi 297 14 test test VB cord-016990-ot1wi3xi 297 15 the the DT cord-016990-ot1wi3xi 297 16 ability ability NN cord-016990-ot1wi3xi 297 17 of of IN cord-016990-ot1wi3xi 297 18 the the DT cord-016990-ot1wi3xi 297 19 virus virus NN cord-016990-ot1wi3xi 297 20 to to TO cord-016990-ot1wi3xi 297 21 replicate replicate VB cord-016990-ot1wi3xi 297 22 and and CC cord-016990-ot1wi3xi 297 23 cause cause VB cord-016990-ot1wi3xi 297 24 disease disease NN cord-016990-ot1wi3xi 297 25 and and CC cord-016990-ot1wi3xi 297 26 facilitate facilitate VB cord-016990-ot1wi3xi 297 27 identification identification NN cord-016990-ot1wi3xi 297 28 of of IN cord-016990-ot1wi3xi 297 29 host host NN cord-016990-ot1wi3xi 297 30 - - HYPH cord-016990-ot1wi3xi 297 31 immune immune JJ cord-016990-ot1wi3xi 297 32 mechanisms mechanism NNS cord-016990-ot1wi3xi 297 33 that that WDT cord-016990-ot1wi3xi 297 34 contribute contribute VBP cord-016990-ot1wi3xi 297 35 to to IN cord-016990-ot1wi3xi 297 36 the the DT cord-016990-ot1wi3xi 297 37 resolution resolution NN cord-016990-ot1wi3xi 297 38 of of IN cord-016990-ot1wi3xi 297 39 SARS SARS NNP cord-016990-ot1wi3xi 297 40 - - HYPH cord-016990-ot1wi3xi 297 41 Co Co NNP cord-016990-ot1wi3xi 297 42 V v NN cord-016990-ot1wi3xi 297 43 infection infection NN cord-016990-ot1wi3xi 297 44 . . . cord-016990-ot1wi3xi 298 1 Cytomegaloviruses Cytomegaloviruses NNP cord-016990-ot1wi3xi 298 2 ( ( -LRB- cord-016990-ot1wi3xi 298 3 CMV CMV NNP cord-016990-ot1wi3xi 298 4 ) ) -RRB- cord-016990-ot1wi3xi 298 5 comprise comprise VBP cord-016990-ot1wi3xi 298 6 a a DT cord-016990-ot1wi3xi 298 7 distinct distinct JJ cord-016990-ot1wi3xi 298 8 and and CC cord-016990-ot1wi3xi 298 9 ancient ancient JJ cord-016990-ot1wi3xi 298 10 group group NN cord-016990-ot1wi3xi 298 11 of of IN cord-016990-ot1wi3xi 298 12 herpesviruses herpesviruses NNP cord-016990-ot1wi3xi 298 13 that that WDT cord-016990-ot1wi3xi 298 14 are be VBP cord-016990-ot1wi3xi 298 15 widely widely RB cord-016990-ot1wi3xi 298 16 distributed distribute VBN cord-016990-ot1wi3xi 298 17 in in IN cord-016990-ot1wi3xi 298 18 nature nature NN cord-016990-ot1wi3xi 298 19 , , , cord-016990-ot1wi3xi 298 20 share share VB cord-016990-ot1wi3xi 298 21 similar similar JJ cord-016990-ot1wi3xi 298 22 growth growth NN cord-016990-ot1wi3xi 298 23 characteristics characteristic NNS cord-016990-ot1wi3xi 298 24 in in IN cord-016990-ot1wi3xi 298 25 cell cell NN cord-016990-ot1wi3xi 298 26 culture culture NN cord-016990-ot1wi3xi 298 27 , , , cord-016990-ot1wi3xi 298 28 and and CC cord-016990-ot1wi3xi 298 29 cause cause VB cord-016990-ot1wi3xi 298 30 cellular cellular JJ cord-016990-ot1wi3xi 298 31 enlargement enlargement NN cord-016990-ot1wi3xi 298 32 and and CC cord-016990-ot1wi3xi 298 33 form form VB cord-016990-ot1wi3xi 298 34 distinctive distinctive JJ cord-016990-ot1wi3xi 298 35 inclusions inclusion NNS cord-016990-ot1wi3xi 298 36 in in IN cord-016990-ot1wi3xi 298 37 infected infected JJ cord-016990-ot1wi3xi 298 38 cells cell NNS cord-016990-ot1wi3xi 298 39 . . . cord-016990-ot1wi3xi 299 1 These these DT cord-016990-ot1wi3xi 299 2 cytopathic cytopathic JJ cord-016990-ot1wi3xi 299 3 changes change NNS cord-016990-ot1wi3xi 299 4 , , , cord-016990-ot1wi3xi 299 5 identified identify VBN cord-016990-ot1wi3xi 299 6 by by IN cord-016990-ot1wi3xi 299 7 early early JJ cord-016990-ot1wi3xi 299 8 pathologists pathologist NNS cord-016990-ot1wi3xi 299 9 in in IN cord-016990-ot1wi3xi 299 10 the the DT cord-016990-ot1wi3xi 299 11 salivary salivary JJ cord-016990-ot1wi3xi 299 12 glands gland NNS cord-016990-ot1wi3xi 299 13 of of IN cord-016990-ot1wi3xi 299 14 children child NNS cord-016990-ot1wi3xi 299 15 dying die VBG cord-016990-ot1wi3xi 299 16 from from IN cord-016990-ot1wi3xi 299 17 various various JJ cord-016990-ot1wi3xi 299 18 unrelated unrelated JJ cord-016990-ot1wi3xi 299 19 diseases,111 diseases,111 NN cord-016990-ot1wi3xi 299 20 - - HYPH cord-016990-ot1wi3xi 299 21 113 113 CD cord-016990-ot1wi3xi 299 22 led lead VBD cord-016990-ot1wi3xi 299 23 to to IN cord-016990-ot1wi3xi 299 24 the the DT cord-016990-ot1wi3xi 299 25 early early JJ cord-016990-ot1wi3xi 299 26 designation designation NN cord-016990-ot1wi3xi 299 27 of of IN cord-016990-ot1wi3xi 299 28 cytomegalic cytomegalic NNP cord-016990-ot1wi3xi 299 29 inclusion inclusion NN cord-016990-ot1wi3xi 299 30 disease disease NN cord-016990-ot1wi3xi 299 31 many many JJ cord-016990-ot1wi3xi 299 32 years year NNS cord-016990-ot1wi3xi 299 33 before before IN cord-016990-ot1wi3xi 299 34 the the DT cord-016990-ot1wi3xi 299 35 causative causative JJ cord-016990-ot1wi3xi 299 36 agent agent NN cord-016990-ot1wi3xi 299 37 was be VBD cord-016990-ot1wi3xi 299 38 isolated isolate VBN cord-016990-ot1wi3xi 299 39 in in IN cord-016990-ot1wi3xi 299 40 the the DT cord-016990-ot1wi3xi 299 41 mid-1950s mid-1950 NNS cord-016990-ot1wi3xi 299 42 . . . cord-016990-ot1wi3xi 300 1 The the DT cord-016990-ot1wi3xi 300 2 name name NN cord-016990-ot1wi3xi 300 3 cytomegalovirus cytomegalovirus NN cord-016990-ot1wi3xi 300 4 was be VBD cord-016990-ot1wi3xi 300 5 proposed propose VBN cord-016990-ot1wi3xi 300 6 in in IN cord-016990-ot1wi3xi 300 7 1960 1960 CD cord-016990-ot1wi3xi 300 8 to to TO cord-016990-ot1wi3xi 300 9 reflect reflect VB cord-016990-ot1wi3xi 300 10 the the DT cord-016990-ot1wi3xi 300 11 cytopathic cytopathic JJ cord-016990-ot1wi3xi 300 12 changes change NNS cord-016990-ot1wi3xi 300 13 caused cause VBN cord-016990-ot1wi3xi 300 14 by by IN cord-016990-ot1wi3xi 300 15 these these DT cord-016990-ot1wi3xi 300 16 viruses virus NNS cord-016990-ot1wi3xi 300 17 . . . cord-016990-ot1wi3xi 301 1 114 114 CD cord-016990-ot1wi3xi 302 1 Cytomegaloviruses cytomegalovirus NNS cord-016990-ot1wi3xi 302 2 are be VBP cord-016990-ot1wi3xi 302 3 highly highly RB cord-016990-ot1wi3xi 302 4 host host NN cord-016990-ot1wi3xi 302 5 - - HYPH cord-016990-ot1wi3xi 302 6 specific specific JJ cord-016990-ot1wi3xi 302 7 , , , cord-016990-ot1wi3xi 302 8 and and CC cord-016990-ot1wi3xi 302 9 various various JJ cord-016990-ot1wi3xi 302 10 mammalian mammalian JJ cord-016990-ot1wi3xi 302 11 hosts host NNS cord-016990-ot1wi3xi 302 12 , , , cord-016990-ot1wi3xi 302 13 including include VBG cord-016990-ot1wi3xi 302 14 nonhuman nonhuman NN cord-016990-ot1wi3xi 302 15 primates primate NNS cord-016990-ot1wi3xi 302 16 , , , cord-016990-ot1wi3xi 302 17 rodents rodent NNS cord-016990-ot1wi3xi 302 18 , , , cord-016990-ot1wi3xi 302 19 and and CC cord-016990-ot1wi3xi 302 20 domesticated domesticated JJ cord-016990-ot1wi3xi 302 21 animals animal NNS cord-016990-ot1wi3xi 302 22 , , , cord-016990-ot1wi3xi 302 23 are be VBP cord-016990-ot1wi3xi 302 24 infected infect VBN cord-016990-ot1wi3xi 302 25 with with IN cord-016990-ot1wi3xi 302 26 their -PRON- PRP$ cord-016990-ot1wi3xi 302 27 own own JJ cord-016990-ot1wi3xi 302 28 distinct distinct JJ cord-016990-ot1wi3xi 302 29 CMY CMY NNP cord-016990-ot1wi3xi 302 30 . . . cord-016990-ot1wi3xi 303 1 In in IN cord-016990-ot1wi3xi 303 2 this this DT cord-016990-ot1wi3xi 303 3 context context NN cord-016990-ot1wi3xi 303 4 , , , cord-016990-ot1wi3xi 303 5 human human JJ cord-016990-ot1wi3xi 303 6 CMV CMV NNP cord-016990-ot1wi3xi 303 7 is be VBZ cord-016990-ot1wi3xi 303 8 stringently stringently RB cord-016990-ot1wi3xi 303 9 species species NN cord-016990-ot1wi3xi 303 10 - - HYPH cord-016990-ot1wi3xi 303 11 specific specific JJ cord-016990-ot1wi3xi 303 12 and and CC cord-016990-ot1wi3xi 303 13 , , , cord-016990-ot1wi3xi 303 14 with with IN cord-016990-ot1wi3xi 303 15 rare rare JJ cord-016990-ot1wi3xi 303 16 exception exception NN cord-016990-ot1wi3xi 303 17 , , , cord-016990-ot1wi3xi 303 18 only only RB cord-016990-ot1wi3xi 303 19 infects infect VBZ cord-016990-ot1wi3xi 303 20 cells cell NNS cord-016990-ot1wi3xi 303 21 of of IN cord-016990-ot1wi3xi 303 22 human human JJ cord-016990-ot1wi3xi 303 23 origin origin NN cord-016990-ot1wi3xi 303 24 . . . cord-016990-ot1wi3xi 304 1 ll5 ll5 NNP cord-016990-ot1wi3xi 304 2 Several several JJ cord-016990-ot1wi3xi 304 3 cell cell NN cord-016990-ot1wi3xi 304 4 types type NNS cord-016990-ot1wi3xi 304 5 are be VBP cord-016990-ot1wi3xi 304 6 permissive permissive JJ cord-016990-ot1wi3xi 304 7 for for IN cord-016990-ot1wi3xi 304 8 CMV CMV NNP cord-016990-ot1wi3xi 304 9 replication replication NN cord-016990-ot1wi3xi 304 10 , , , cord-016990-ot1wi3xi 304 11 including include VBG cord-016990-ot1wi3xi 304 12 alveolar alveolar NN cord-016990-ot1wi3xi 304 13 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 304 14 , , , cord-016990-ot1wi3xi 304 15 vascular vascular JJ cord-016990-ot1wi3xi 304 16 endothelium endothelium NN cord-016990-ot1wi3xi 304 17 , , , cord-016990-ot1wi3xi 304 18 fibroblasts fibroblast NNS cord-016990-ot1wi3xi 304 19 , , , cord-016990-ot1wi3xi 304 20 monocytes monocyte NNS cord-016990-ot1wi3xi 304 21 , , , cord-016990-ot1wi3xi 304 22 dendritic dendritic JJ cord-016990-ot1wi3xi 304 23 cells cell NNS cord-016990-ot1wi3xi 304 24 , , , cord-016990-ot1wi3xi 304 25 and and CC cord-016990-ot1wi3xi 304 26 exocrine exocrine JJ cord-016990-ot1wi3xi 304 27 and and CC cord-016990-ot1wi3xi 304 28 endocrine endocrine JJ cord-016990-ot1wi3xi 304 29 glandular glandular JJ cord-016990-ot1wi3xi 304 30 epithelial epithelial NN cord-016990-ot1wi3xi 304 31 cells.ll6 cells.ll6 NFP cord-016990-ot1wi3xi 304 32 Cytomegalovirus Cytomegalovirus NNP cord-016990-ot1wi3xi 304 33 is be VBZ cord-016990-ot1wi3xi 304 34 a a DT cord-016990-ot1wi3xi 304 35 ~-herpesvirus ~-herpesvirus XX cord-016990-ot1wi3xi 305 1 with with IN cord-016990-ot1wi3xi 305 2 the the DT cord-016990-ot1wi3xi 305 3 largest large JJS cord-016990-ot1wi3xi 305 4 genome genome NN cord-016990-ot1wi3xi 305 5 ( ( -LRB- cord-016990-ot1wi3xi 305 6 230 230 CD cord-016990-ot1wi3xi 305 7 kilobase kilobase NNP cord-016990-ot1wi3xi 305 8 pair pair NN cord-016990-ot1wi3xi 305 9 [ [ -LRB- cord-016990-ot1wi3xi 305 10 kbp kbp NNP cord-016990-ot1wi3xi 305 11 ] ] -RRB- cord-016990-ot1wi3xi 305 12 ) ) -RRB- cord-016990-ot1wi3xi 305 13 of of IN cord-016990-ot1wi3xi 305 14 all all PDT cord-016990-ot1wi3xi 305 15 the the DT cord-016990-ot1wi3xi 305 16 herpesviruses herpesviruse NNS cord-016990-ot1wi3xi 305 17 known know VBN cord-016990-ot1wi3xi 305 18 to to TO cord-016990-ot1wi3xi 305 19 infect infect VB cord-016990-ot1wi3xi 305 20 humans human NNS cord-016990-ot1wi3xi 305 21 . . . cord-016990-ot1wi3xi 306 1 The the DT cord-016990-ot1wi3xi 306 2 double double RB cord-016990-ot1wi3xi 306 3 - - HYPH cord-016990-ot1wi3xi 306 4 stranded stranded JJ cord-016990-ot1wi3xi 306 5 linear linear JJ cord-016990-ot1wi3xi 306 6 DNA dna NN cord-016990-ot1wi3xi 306 7 genome genome NN cord-016990-ot1wi3xi 306 8 is be VBZ cord-016990-ot1wi3xi 306 9 contained contain VBN cord-016990-ot1wi3xi 306 10 within within IN cord-016990-ot1wi3xi 306 11 a a DT cord-016990-ot1wi3xi 306 12 90 90 CD cord-016990-ot1wi3xi 306 13 to to TO cord-016990-ot1wi3xi 306 14 100 100 CD cord-016990-ot1wi3xi 306 15 nm nm NN cord-016990-ot1wi3xi 306 16 icosahedral icosahedral JJ cord-016990-ot1wi3xi 306 17 capsid capsid NN cord-016990-ot1wi3xi 306 18 and and CC cord-016990-ot1wi3xi 306 19 is be VBZ cord-016990-ot1wi3xi 306 20 surrounded surround VBN cord-016990-ot1wi3xi 306 21 by by IN cord-016990-ot1wi3xi 306 22 an an DT cord-016990-ot1wi3xi 306 23 amorphous amorphous JJ cord-016990-ot1wi3xi 306 24 material material NN cord-016990-ot1wi3xi 306 25 known know VBN cord-016990-ot1wi3xi 306 26 as as IN cord-016990-ot1wi3xi 306 27 the the DT cord-016990-ot1wi3xi 306 28 tegument tegument NN cord-016990-ot1wi3xi 306 29 . . . cord-016990-ot1wi3xi 307 1 These these DT cord-016990-ot1wi3xi 307 2 components component NNS cord-016990-ot1wi3xi 307 3 are be VBP cord-016990-ot1wi3xi 307 4 enclosed enclose VBN cord-016990-ot1wi3xi 307 5 in in IN cord-016990-ot1wi3xi 307 6 a a DT cord-016990-ot1wi3xi 307 7 lipid lipid NN cord-016990-ot1wi3xi 307 8 bilayer bilayer NN cord-016990-ot1wi3xi 307 9 envelope envelope NN cord-016990-ot1wi3xi 307 10 that that WDT cord-016990-ot1wi3xi 307 11 is be VBZ cord-016990-ot1wi3xi 307 12 derived derive VBN cord-016990-ot1wi3xi 307 13 from from IN cord-016990-ot1wi3xi 307 14 the the DT cord-016990-ot1wi3xi 307 15 host host NN cord-016990-ot1wi3xi 307 16 cell cell NN cord-016990-ot1wi3xi 307 17 nuclear nuclear NN cord-016990-ot1wi3xi 307 18 or or CC cord-016990-ot1wi3xi 307 19 Golgi Golgi NNP cord-016990-ot1wi3xi 307 20 membranes membrane NNS cord-016990-ot1wi3xi 307 21 and and CC cord-016990-ot1wi3xi 307 22 contains contain VBZ cord-016990-ot1wi3xi 307 23 several several JJ cord-016990-ot1wi3xi 307 24 vir vir NNP cord-016990-ot1wi3xi 307 25 ally ally NN cord-016990-ot1wi3xi 307 26 encoded encode VBD cord-016990-ot1wi3xi 307 27 glycoproteins glycoprotein NNS cord-016990-ot1wi3xi 307 28 necessary necessary JJ cord-016990-ot1wi3xi 307 29 for for IN cord-016990-ot1wi3xi 307 30 infection infection NN cord-016990-ot1wi3xi 307 31 of of IN cord-016990-ot1wi3xi 307 32 other other JJ cord-016990-ot1wi3xi 307 33 cells cell NNS cord-016990-ot1wi3xi 307 34 . . . cord-016990-ot1wi3xi 308 1 Mature mature JJ cord-016990-ot1wi3xi 308 2 enveloped envelop VBN cord-016990-ot1wi3xi 308 3 virions virion NNS cord-016990-ot1wi3xi 308 4 range range VBP cord-016990-ot1wi3xi 308 5 from from IN cord-016990-ot1wi3xi 308 6 150 150 CD cord-016990-ot1wi3xi 308 7 to to IN cord-016990-ot1wi3xi 308 8 200 200 CD cord-016990-ot1wi3xi 308 9 nm nm NN cord-016990-ot1wi3xi 308 10 , , , cord-016990-ot1wi3xi 308 11 making make VBG cord-016990-ot1wi3xi 308 12 CMV CMV NNP cord-016990-ot1wi3xi 308 13 one one CD cord-016990-ot1wi3xi 308 14 of of IN cord-016990-ot1wi3xi 308 15 the the DT cord-016990-ot1wi3xi 308 16 largest large JJS cord-016990-ot1wi3xi 308 17 viruses virus NNS cord-016990-ot1wi3xi 308 18 that that WDT cord-016990-ot1wi3xi 308 19 infect infect VBP cord-016990-ot1wi3xi 308 20 humans human NNS cord-016990-ot1wi3xi 308 21 ( ( -LRB- cord-016990-ot1wi3xi 308 22 Fig fig NN cord-016990-ot1wi3xi 308 23 . . . cord-016990-ot1wi3xi 308 24 I1.1D i1.1d NN cord-016990-ot1wi3xi 308 25 ) ) -RRB- cord-016990-ot1wi3xi 308 26 .ll7 .ll7 . cord-016990-ot1wi3xi 309 1 The the DT cord-016990-ot1wi3xi 309 2 structure structure NN cord-016990-ot1wi3xi 309 3 of of IN cord-016990-ot1wi3xi 309 4 CMV CMV NNP cord-016990-ot1wi3xi 309 5 is be VBZ cord-016990-ot1wi3xi 309 6 typical typical JJ cord-016990-ot1wi3xi 309 7 of of IN cord-016990-ot1wi3xi 309 8 other other JJ cord-016990-ot1wi3xi 309 9 human human JJ cord-016990-ot1wi3xi 309 10 herpesviruses herpesviruse NNS cord-016990-ot1wi3xi 309 11 , , , cord-016990-ot1wi3xi 309 12 but but CC cord-016990-ot1wi3xi 309 13 demonstrates demonstrate VBZ cord-016990-ot1wi3xi 309 14 some some DT cord-016990-ot1wi3xi 309 15 subtle subtle JJ cord-016990-ot1wi3xi 309 16 ultrastructural ultrastructural JJ cord-016990-ot1wi3xi 309 17 differences difference NNS cord-016990-ot1wi3xi 309 18 from from IN cord-016990-ot1wi3xi 309 19 other other JJ cord-016990-ot1wi3xi 309 20 viruses virus NNS cord-016990-ot1wi3xi 309 21 in in IN cord-016990-ot1wi3xi 309 22 this this DT cord-016990-ot1wi3xi 309 23 group group NN cord-016990-ot1wi3xi 309 24 including include VBG cord-016990-ot1wi3xi 309 25 greater great JJR cord-016990-ot1wi3xi 309 26 pleomorphism pleomorphism NN cord-016990-ot1wi3xi 309 27 of of IN cord-016990-ot1wi3xi 309 28 the the DT cord-016990-ot1wi3xi 309 29 lipid lipid NN cord-016990-ot1wi3xi 309 30 envelope envelope NN cord-016990-ot1wi3xi 309 31 and and CC cord-016990-ot1wi3xi 309 32 dense dense JJ cord-016990-ot1wi3xi 309 33 body body NN cord-016990-ot1wi3xi 309 34 inclusions inclusion NNS cord-016990-ot1wi3xi 309 35 in in IN cord-016990-ot1wi3xi 309 36 the the DT cord-016990-ot1wi3xi 309 37 cytoplasm cytoplasm NN cord-016990-ot1wi3xi 309 38 of of IN cord-016990-ot1wi3xi 309 39 infected infect VBN cord-016990-ot1wi3xi 309 40 cells.ll8 cells.ll8 CD cord-016990-ot1wi3xi 309 41 437 437 CD cord-016990-ot1wi3xi 309 42 Cytomegalovirus Cytomegalovirus NNP cord-016990-ot1wi3xi 309 43 is be VBZ cord-016990-ot1wi3xi 309 44 a a DT cord-016990-ot1wi3xi 309 45 ubiquitous ubiquitous JJ cord-016990-ot1wi3xi 309 46 human human JJ cord-016990-ot1wi3xi 309 47 pathogen pathogen NN cord-016990-ot1wi3xi 309 48 , , , cord-016990-ot1wi3xi 309 49 and and CC cord-016990-ot1wi3xi 309 50 in in IN cord-016990-ot1wi3xi 309 51 North North NNP cord-016990-ot1wi3xi 309 52 America America NNP cord-016990-ot1wi3xi 309 53 infects infect VBZ cord-016990-ot1wi3xi 309 54 approximately approximately RB cord-016990-ot1wi3xi 309 55 50 50 CD cord-016990-ot1wi3xi 309 56 % % NN cord-016990-ot1wi3xi 309 57 to to TO cord-016990-ot1wi3xi 309 58 90 90 CD cord-016990-ot1wi3xi 309 59 % % NN cord-016990-ot1wi3xi 309 60 of of IN cord-016990-ot1wi3xi 309 61 the the DT cord-016990-ot1wi3xi 309 62 population.ll7 population.ll7 NNPS cord-016990-ot1wi3xi 309 63 Most Most JJS cord-016990-ot1wi3xi 309 64 of of IN cord-016990-ot1wi3xi 309 65 these these DT cord-016990-ot1wi3xi 309 66 infections infection NNS cord-016990-ot1wi3xi 309 67 are be VBP cord-016990-ot1wi3xi 309 68 inapparent inapparent JJ cord-016990-ot1wi3xi 309 69 , , , cord-016990-ot1wi3xi 309 70 although although IN cord-016990-ot1wi3xi 309 71 some some DT cord-016990-ot1wi3xi 309 72 cases case NNS cord-016990-ot1wi3xi 309 73 of of IN cord-016990-ot1wi3xi 309 74 primary primary JJ cord-016990-ot1wi3xi 309 75 infection infection NN cord-016990-ot1wi3xi 309 76 in in IN cord-016990-ot1wi3xi 309 77 otherwise otherwise RB cord-016990-ot1wi3xi 309 78 healthy healthy JJ cord-016990-ot1wi3xi 309 79 individuals individual NNS cord-016990-ot1wi3xi 309 80 result result VBP cord-016990-ot1wi3xi 309 81 in in IN cord-016990-ot1wi3xi 309 82 a a DT cord-016990-ot1wi3xi 309 83 self self NN cord-016990-ot1wi3xi 309 84 - - HYPH cord-016990-ot1wi3xi 309 85 limited limit VBN cord-016990-ot1wi3xi 309 86 mononucleosis mononucleosis NN cord-016990-ot1wi3xi 309 87 syndrome syndrome NN cord-016990-ot1wi3xi 309 88 similar similar JJ cord-016990-ot1wi3xi 309 89 to to IN cord-016990-ot1wi3xi 309 90 that that DT cord-016990-ot1wi3xi 309 91 caused cause VBN cord-016990-ot1wi3xi 309 92 by by IN cord-016990-ot1wi3xi 309 93 Epstein Epstein NNP cord-016990-ot1wi3xi 309 94 - - HYPH cord-016990-ot1wi3xi 309 95 Barr Barr NNP cord-016990-ot1wi3xi 309 96 virus virus NN cord-016990-ot1wi3xi 309 97 ; ; : cord-016990-ot1wi3xi 309 98 it -PRON- PRP cord-016990-ot1wi3xi 309 99 is be VBZ cord-016990-ot1wi3xi 309 100 estimated estimate VBN cord-016990-ot1wi3xi 309 101 that that IN cord-016990-ot1wi3xi 309 102 20 20 CD cord-016990-ot1wi3xi 309 103 % % NN cord-016990-ot1wi3xi 309 104 to to TO cord-016990-ot1wi3xi 309 105 50 50 CD cord-016990-ot1wi3xi 309 106 % % NN cord-016990-ot1wi3xi 309 107 of of IN cord-016990-ot1wi3xi 309 108 cases case NNS cord-016990-ot1wi3xi 309 109 of of IN cord-016990-ot1wi3xi 309 110 heterophile heterophile NN cord-016990-ot1wi3xi 309 111 - - HYPH cord-016990-ot1wi3xi 309 112 negative negative JJ cord-016990-ot1wi3xi 309 113 mononucleosis mononucleosis NN cord-016990-ot1wi3xi 309 114 , , , cord-016990-ot1wi3xi 309 115 and and CC cord-016990-ot1wi3xi 309 116 8 8 CD cord-016990-ot1wi3xi 309 117 % % NN cord-016990-ot1wi3xi 309 118 of of IN cord-016990-ot1wi3xi 309 119 all all DT cord-016990-ot1wi3xi 309 120 cases case NNS cord-016990-ot1wi3xi 309 121 of of IN cord-016990-ot1wi3xi 309 122 mononucleosis mononucleosis NN cord-016990-ot1wi3xi 309 123 , , , cord-016990-ot1wi3xi 309 124 are be VBP cord-016990-ot1wi3xi 309 125 caused cause VBN cord-016990-ot1wi3xi 309 126 by by IN cord-016990-ot1wi3xi 309 127 CMy CMy NNS cord-016990-ot1wi3xi 309 128 ' ' POS cord-016990-ot1wi3xi 309 129 119 119 CD cord-016990-ot1wi3xi 309 130 Pulmonary pulmonary JJ cord-016990-ot1wi3xi 309 131 involvement involvement NN cord-016990-ot1wi3xi 309 132 in in IN cord-016990-ot1wi3xi 309 133 CMV CMV NNP cord-016990-ot1wi3xi 309 134 mononucleosis mononucleosis NN cord-016990-ot1wi3xi 309 135 is be VBZ cord-016990-ot1wi3xi 309 136 infrequent infrequent JJ cord-016990-ot1wi3xi 309 137 and and CC cord-016990-ot1wi3xi 309 138 occurs occur VBZ cord-016990-ot1wi3xi 309 139 in in IN cord-016990-ot1wi3xi 309 140 approximately approximately RB cord-016990-ot1wi3xi 309 141 6 6 CD cord-016990-ot1wi3xi 309 142 % % NN cord-016990-ot1wi3xi 309 143 of of IN cord-016990-ot1wi3xi 309 144 these these DT cord-016990-ot1wi3xi 309 145 casesYo casesyo CD cord-016990-ot1wi3xi 309 146 Congenitally congenitally RB cord-016990-ot1wi3xi 310 1 acquired acquire VBD cord-016990-ot1wi3xi 310 2 CMV CMV NNP cord-016990-ot1wi3xi 310 3 infection infection NN cord-016990-ot1wi3xi 310 4 has have VBZ cord-016990-ot1wi3xi 310 5 various various JJ cord-016990-ot1wi3xi 310 6 deleterious deleterious JJ cord-016990-ot1wi3xi 310 7 effects effect NNS cord-016990-ot1wi3xi 310 8 on on IN cord-016990-ot1wi3xi 310 9 the the DT cord-016990-ot1wi3xi 310 10 fetus fetus NN cord-016990-ot1wi3xi 310 11 , , , cord-016990-ot1wi3xi 310 12 including include VBG cord-016990-ot1wi3xi 310 13 mental mental JJ cord-016990-ot1wi3xi 310 14 retardation retardation NN cord-016990-ot1wi3xi 310 15 , , , cord-016990-ot1wi3xi 310 16 neurologic neurologic JJ cord-016990-ot1wi3xi 310 17 abnormalities abnormality NNS cord-016990-ot1wi3xi 310 18 , , , cord-016990-ot1wi3xi 310 19 sensorineural sensorineural JJ cord-016990-ot1wi3xi 310 20 hearing hearing NN cord-016990-ot1wi3xi 310 21 loss loss NN cord-016990-ot1wi3xi 310 22 , , , cord-016990-ot1wi3xi 310 23 and and CC cord-016990-ot1wi3xi 310 24 retinitis retinitis NN cord-016990-ot1wi3xi 310 25 , , , cord-016990-ot1wi3xi 310 26 and and CC cord-016990-ot1wi3xi 310 27 in in IN cord-016990-ot1wi3xi 310 28 one one CD cord-016990-ot1wi3xi 310 29 series series NN cord-016990-ot1wi3xi 310 30 pulmonary pulmonary JJ cord-016990-ot1wi3xi 310 31 involvement involvement NN cord-016990-ot1wi3xi 310 32 occurred occur VBD cord-016990-ot1wi3xi 310 33 in in IN cord-016990-ot1wi3xi 310 34 64 64 CD cord-016990-ot1wi3xi 310 35 % % NN cord-016990-ot1wi3xi 310 36 of of IN cord-016990-ot1wi3xi 310 37 symptomatic symptomatic JJ cord-016990-ot1wi3xi 310 38 infants infant NNS cord-016990-ot1wi3xi 310 39 . . . cord-016990-ot1wi3xi 311 1 121 121 CD cord-016990-ot1wi3xi 312 1 Like like IN cord-016990-ot1wi3xi 312 2 all all DT cord-016990-ot1wi3xi 312 3 herpesviruses herpesviruse NNS cord-016990-ot1wi3xi 312 4 , , , cord-016990-ot1wi3xi 312 5 CMV CMV NNP cord-016990-ot1wi3xi 312 6 remains remain VBZ cord-016990-ot1wi3xi 312 7 with with IN cord-016990-ot1wi3xi 312 8 its -PRON- PRP$ cord-016990-ot1wi3xi 312 9 host host NN cord-016990-ot1wi3xi 312 10 for for IN cord-016990-ot1wi3xi 312 11 life life NN cord-016990-ot1wi3xi 312 12 after after IN cord-016990-ot1wi3xi 312 13 primary primary JJ cord-016990-ot1wi3xi 312 14 infection infection NN cord-016990-ot1wi3xi 312 15 and and CC cord-016990-ot1wi3xi 312 16 establishes establish VBZ cord-016990-ot1wi3xi 312 17 latency latency NN cord-016990-ot1wi3xi 312 18 in in IN cord-016990-ot1wi3xi 312 19 various various JJ cord-016990-ot1wi3xi 312 20 cell cell NN cord-016990-ot1wi3xi 312 21 types type NNS cord-016990-ot1wi3xi 312 22 , , , cord-016990-ot1wi3xi 312 23 including include VBG cord-016990-ot1wi3xi 312 24 vascular vascular JJ cord-016990-ot1wi3xi 312 25 endothelial endothelial JJ cord-016990-ot1wi3xi 312 26 cells cell NNS cord-016990-ot1wi3xi 312 27 , , , cord-016990-ot1wi3xi 312 28 monocytes monocyte NNS cord-016990-ot1wi3xi 312 29 and and CC cord-016990-ot1wi3xi 312 30 macrophages macrophage NNS cord-016990-ot1wi3xi 312 31 , , , cord-016990-ot1wi3xi 312 32 neutrophils neutrophil NNS cord-016990-ot1wi3xi 312 33 , , , cord-016990-ot1wi3xi 312 34 and and CC cord-016990-ot1wi3xi 312 35 renal renal JJ cord-016990-ot1wi3xi 312 36 and and CC cord-016990-ot1wi3xi 312 37 pulmonary pulmonary JJ cord-016990-ot1wi3xi 312 38 epithelial epithelial JJ cord-016990-ot1wi3xi 312 39 cells cell NNS cord-016990-ot1wi3xi 312 40 . . . cord-016990-ot1wi3xi 313 1 122 122 CD cord-016990-ot1wi3xi 313 2 Activation activation NN cord-016990-ot1wi3xi 313 3 of of IN cord-016990-ot1wi3xi 313 4 viral viral JJ cord-016990-ot1wi3xi 313 5 replication replication NN cord-016990-ot1wi3xi 313 6 occurs occur VBZ cord-016990-ot1wi3xi 313 7 in in IN cord-016990-ot1wi3xi 313 8 persons person NNS cord-016990-ot1wi3xi 313 9 with with IN cord-016990-ot1wi3xi 313 10 severely severely RB cord-016990-ot1wi3xi 313 11 compromised compromise VBN cord-016990-ot1wi3xi 313 12 immunity immunity NN cord-016990-ot1wi3xi 313 13 . . . cord-016990-ot1wi3xi 314 1 Patients patient NNS cord-016990-ot1wi3xi 314 2 with with IN cord-016990-ot1wi3xi 314 3 advanced advanced JJ cord-016990-ot1wi3xi 314 4 HIV HIV NNP cord-016990-ot1wi3xi 314 5 disease disease NN cord-016990-ot1wi3xi 314 6 and and CC cord-016990-ot1wi3xi 314 7 recipients recipient NNS cord-016990-ot1wi3xi 314 8 of of IN cord-016990-ot1wi3xi 314 9 hematopoietic hematopoietic JJ cord-016990-ot1wi3xi 314 10 stem stem NN cord-016990-ot1wi3xi 314 11 cell cell NN cord-016990-ot1wi3xi 314 12 or or CC cord-016990-ot1wi3xi 314 13 lung lung NN cord-016990-ot1wi3xi 314 14 transplants transplant NNS cord-016990-ot1wi3xi 314 15 are be VBP cord-016990-ot1wi3xi 314 16 particularly particularly RB cord-016990-ot1wi3xi 314 17 at at IN cord-016990-ot1wi3xi 314 18 risk risk NN cord-016990-ot1wi3xi 314 19 of of IN cord-016990-ot1wi3xi 314 20 developing develop VBG cord-016990-ot1wi3xi 314 21 CMV CMV NNP cord-016990-ot1wi3xi 314 22 pneumonia pneumonia NN cord-016990-ot1wi3xi 314 23 . . . cord-016990-ot1wi3xi 315 1 Before before IN cord-016990-ot1wi3xi 315 2 the the DT cord-016990-ot1wi3xi 315 3 use use NN cord-016990-ot1wi3xi 315 4 of of IN cord-016990-ot1wi3xi 315 5 CMV CMV NNP cord-016990-ot1wi3xi 315 6 screening screening NN cord-016990-ot1wi3xi 315 7 and and CC cord-016990-ot1wi3xi 315 8 effective effective JJ cord-016990-ot1wi3xi 315 9 antiviral antiviral JJ cord-016990-ot1wi3xi 315 10 prophylaxis prophylaxis NN cord-016990-ot1wi3xi 315 11 regimens regimen NNS cord-016990-ot1wi3xi 315 12 , , , cord-016990-ot1wi3xi 315 13 10 10 CD cord-016990-ot1wi3xi 315 14 % % NN cord-016990-ot1wi3xi 315 15 to to TO cord-016990-ot1wi3xi 315 16 30 30 CD cord-016990-ot1wi3xi 315 17 % % NN cord-016990-ot1wi3xi 315 18 of of IN cord-016990-ot1wi3xi 315 19 all all DT cord-016990-ot1wi3xi 315 20 patients patient NNS cord-016990-ot1wi3xi 315 21 undergoing undergo VBG cord-016990-ot1wi3xi 315 22 allogeneic allogeneic IN cord-016990-ot1wi3xi 315 23 bone bone NN cord-016990-ot1wi3xi 315 24 marrow marrow NN cord-016990-ot1wi3xi 315 25 transplantation transplantation NN cord-016990-ot1wi3xi 315 26 for for IN cord-016990-ot1wi3xi 315 27 leukemia leukemia NN cord-016990-ot1wi3xi 315 28 , , , cord-016990-ot1wi3xi 315 29 and and CC cord-016990-ot1wi3xi 315 30 15 15 CD cord-016990-ot1wi3xi 315 31 % % NN cord-016990-ot1wi3xi 315 32 to to TO cord-016990-ot1wi3xi 315 33 55 55 CD cord-016990-ot1wi3xi 315 34 % % NN cord-016990-ot1wi3xi 315 35 of of IN cord-016990-ot1wi3xi 315 36 solid solid JJ cord-016990-ot1wi3xi 315 37 organ organ NN cord-016990-ot1wi3xi 315 38 transplants transplant NNS cord-016990-ot1wi3xi 315 39 , , , cord-016990-ot1wi3xi 315 40 developed develop VBD cord-016990-ot1wi3xi 315 41 CMV CMV NNP cord-016990-ot1wi3xi 315 42 pneumonia pneumonia NN cord-016990-ot1wi3xi 315 43 with with IN cord-016990-ot1wi3xi 315 44 case case NN cord-016990-ot1wi3xi 315 45 fatality fatality NN cord-016990-ot1wi3xi 315 46 rates rate NNS cord-016990-ot1wi3xi 315 47 of of IN cord-016990-ot1wi3xi 315 48 greater great JJR cord-016990-ot1wi3xi 315 49 than than IN cord-016990-ot1wi3xi 315 50 80 80 CD cord-016990-ot1wi3xi 315 51 % % NN cord-016990-ot1wi3xi 315 52 in in IN cord-016990-ot1wi3xi 315 53 some some DT cord-016990-ot1wi3xi 315 54 series series NN cord-016990-ot1wi3xi 315 55 . . . cord-016990-ot1wi3xi 316 1 26 26 CD cord-016990-ot1wi3xi 316 2 , , , cord-016990-ot1wi3xi 316 3 123,124 123,124 CD cord-016990-ot1wi3xi 317 1 The the DT cord-016990-ot1wi3xi 317 2 relatively relatively RB cord-016990-ot1wi3xi 317 3 high high JJ cord-016990-ot1wi3xi 317 4 frequency frequency NN cord-016990-ot1wi3xi 317 5 of of IN cord-016990-ot1wi3xi 317 6 CMV CMV NNP cord-016990-ot1wi3xi 317 7 pneumonia pneumonia NN cord-016990-ot1wi3xi 317 8 in in IN cord-016990-ot1wi3xi 317 9 lung lung NN cord-016990-ot1wi3xi 317 10 transplant transplant NN cord-016990-ot1wi3xi 317 11 recipients recipient NNS cord-016990-ot1wi3xi 317 12 may may MD cord-016990-ot1wi3xi 317 13 be be VB cord-016990-ot1wi3xi 317 14 a a DT cord-016990-ot1wi3xi 317 15 correlate correlate NN cord-016990-ot1wi3xi 317 16 of of IN cord-016990-ot1wi3xi 317 17 animal animal NN cord-016990-ot1wi3xi 317 18 model model NN cord-016990-ot1wi3xi 317 19 data datum NNS cord-016990-ot1wi3xi 317 20 that that WDT cord-016990-ot1wi3xi 317 21 indicate indicate VBP cord-016990-ot1wi3xi 317 22 the the DT cord-016990-ot1wi3xi 317 23 lungs lung NNS cord-016990-ot1wi3xi 317 24 are be VBP cord-016990-ot1wi3xi 317 25 a a DT cord-016990-ot1wi3xi 317 26 major major JJ cord-016990-ot1wi3xi 317 27 site site NN cord-016990-ot1wi3xi 317 28 of of IN cord-016990-ot1wi3xi 317 29 latent latent JJ cord-016990-ot1wi3xi 317 30 CMV CMV NNP cord-016990-ot1wi3xi 317 31 infection infection NN cord-016990-ot1wi3xi 317 32 . . . cord-016990-ot1wi3xi 318 1 125 125 CD cord-016990-ot1wi3xi 319 1 Before before IN cord-016990-ot1wi3xi 319 2 the the DT cord-016990-ot1wi3xi 319 3 use use NN cord-016990-ot1wi3xi 319 4 of of IN cord-016990-ot1wi3xi 319 5 ganciclovir ganciclovir NNP cord-016990-ot1wi3xi 319 6 as as IN cord-016990-ot1wi3xi 319 7 therapy therapy NN cord-016990-ot1wi3xi 319 8 for for IN cord-016990-ot1wi3xi 319 9 CMV CMV NNP cord-016990-ot1wi3xi 319 10 disease disease NN cord-016990-ot1wi3xi 319 11 in in IN cord-016990-ot1wi3xi 319 12 AIDS AIDS NNP cord-016990-ot1wi3xi 319 13 patients patient NNS cord-016990-ot1wi3xi 319 14 , , , cord-016990-ot1wi3xi 319 15 the the DT cord-016990-ot1wi3xi 319 16 case case NN cord-016990-ot1wi3xi 319 17 fatality fatality NN cord-016990-ot1wi3xi 319 18 rate rate NN cord-016990-ot1wi3xi 319 19 for for IN cord-016990-ot1wi3xi 319 20 CMV CMV NNP cord-016990-ot1wi3xi 319 21 pneumonia pneumonia NN cord-016990-ot1wi3xi 319 22 in in IN cord-016990-ot1wi3xi 319 23 this this DT cord-016990-ot1wi3xi 319 24 patient patient JJ cord-016990-ot1wi3xi 319 25 cohort cohort NN cord-016990-ot1wi3xi 319 26 was be VBD cord-016990-ot1wi3xi 319 27 75 75 CD cord-016990-ot1wi3xi 319 28 % % NN cord-016990-ot1wi3xi 319 29 when when WRB cord-016990-ot1wi3xi 319 30 CMV CMV NNP cord-016990-ot1wi3xi 319 31 was be VBD cord-016990-ot1wi3xi 319 32 the the DT cord-016990-ot1wi3xi 319 33 only only JJ cord-016990-ot1wi3xi 319 34 pathogen pathogen NN cord-016990-ot1wi3xi 319 35 identified identify VBN cord-016990-ot1wi3xi 319 36 . . . cord-016990-ot1wi3xi 320 1 Mixed mixed JJ cord-016990-ot1wi3xi 320 2 infections infection NNS cord-016990-ot1wi3xi 320 3 with with IN cord-016990-ot1wi3xi 320 4 CMV CMV NNP cord-016990-ot1wi3xi 320 5 and and CC cord-016990-ot1wi3xi 320 6 another another DT cord-016990-ot1wi3xi 320 7 pathogen pathogen NN cord-016990-ot1wi3xi 320 8 had have VBD cord-016990-ot1wi3xi 320 9 an an DT cord-016990-ot1wi3xi 320 10 even even RB cord-016990-ot1wi3xi 320 11 worse bad JJR cord-016990-ot1wi3xi 320 12 prognosis prognosis NN cord-016990-ot1wi3xi 320 13 , , , cord-016990-ot1wi3xi 320 14 and and CC cord-016990-ot1wi3xi 320 15 the the DT cord-016990-ot1wi3xi 320 16 case case NN cord-016990-ot1wi3xi 320 17 fatality fatality NN cord-016990-ot1wi3xi 320 18 rate rate NN cord-016990-ot1wi3xi 320 19 for for IN cord-016990-ot1wi3xi 320 20 patients patient NNS cord-016990-ot1wi3xi 320 21 with with IN cord-016990-ot1wi3xi 320 22 pulmonary pulmonary JJ cord-016990-ot1wi3xi 320 23 disease disease NN cord-016990-ot1wi3xi 320 24 caused cause VBN cord-016990-ot1wi3xi 320 25 by by IN cord-016990-ot1wi3xi 320 26 CMV CMV NNP cord-016990-ot1wi3xi 320 27 and and CC cord-016990-ot1wi3xi 320 28 Pneumocystis Pneumocystis NNP cord-016990-ot1wi3xi 320 29 jiroveci jiroveci NNP cord-016990-ot1wi3xi 320 30 ( ( -LRB- cord-016990-ot1wi3xi 320 31 formerly formerly RB cord-016990-ot1wi3xi 320 32 carinii carinii FW cord-016990-ot1wi3xi 320 33 ) ) -RRB- cord-016990-ot1wi3xi 320 34 was be VBD cord-016990-ot1wi3xi 320 35 92 92 CD cord-016990-ot1wi3xi 320 36 % % NN cord-016990-ot1wi3xi 320 37 . . . cord-016990-ot1wi3xi 321 1 126 126 CD cord-016990-ot1wi3xi 321 2 Cytomegalovirus Cytomegalovirus NNP cord-016990-ot1wi3xi 321 3 pneumonia pneumonia NN cord-016990-ot1wi3xi 321 4 can can MD cord-016990-ot1wi3xi 321 5 show show VB cord-016990-ot1wi3xi 321 6 various various JJ cord-016990-ot1wi3xi 321 7 histopathologic histopathologic JJ cord-016990-ot1wi3xi 321 8 patterns pattern NNS cord-016990-ot1wi3xi 321 9 ( ( -LRB- cord-016990-ot1wi3xi 321 10 Fig Fig NNP cord-016990-ot1wi3xi 321 11 . . . cord-016990-ot1wi3xi 321 12 11 11 CD cord-016990-ot1wi3xi 321 13 .5 .5 CD cord-016990-ot1wi3xi 321 14 ) ) -RRB- cord-016990-ot1wi3xi 321 15 . . . cord-016990-ot1wi3xi 322 1 Extensive extensive JJ cord-016990-ot1wi3xi 322 2 intra intra JJ cord-016990-ot1wi3xi 322 3 alveolar alveolar NN cord-016990-ot1wi3xi 322 4 hemorrhage hemorrhage NN cord-016990-ot1wi3xi 322 5 with with IN cord-016990-ot1wi3xi 322 6 scattered scatter VBN cord-016990-ot1wi3xi 322 7 cytomegalic cytomegalic NN cord-016990-ot1wi3xi 322 8 cells cell NNS cord-016990-ot1wi3xi 322 9 and and CC cord-016990-ot1wi3xi 322 10 relatively relatively RB cord-016990-ot1wi3xi 322 11 few few JJ cord-016990-ot1wi3xi 322 12 inflammatory inflammatory JJ cord-016990-ot1wi3xi 322 13 cell cell NN cord-016990-ot1wi3xi 322 14 infiltrates infiltrate NNS cord-016990-ot1wi3xi 322 15 may may MD cord-016990-ot1wi3xi 322 16 occur occur VB cord-016990-ot1wi3xi 322 17 ( ( -LRB- cord-016990-ot1wi3xi 322 18 Fig fig NN cord-016990-ot1wi3xi 322 19 . . . cord-016990-ot1wi3xi 322 20 _SP cord-016990-ot1wi3xi 323 1 11 11 CD cord-016990-ot1wi3xi 323 2 .5A).127 .5A).127 . cord-016990-ot1wi3xi 324 1 In in IN cord-016990-ot1wi3xi 324 2 a a DT cord-016990-ot1wi3xi 324 3 similar similar JJ cord-016990-ot1wi3xi 324 4 manner manner NN cord-016990-ot1wi3xi 324 5 , , , cord-016990-ot1wi3xi 324 6 extensive extensive JJ cord-016990-ot1wi3xi 324 7 involvement involvement NN cord-016990-ot1wi3xi 324 8 of of IN cord-016990-ot1wi3xi 324 9 the the DT cord-016990-ot1wi3xi 324 10 alveolar alveolar JJ cord-016990-ot1wi3xi 324 11 epithelium epithelium NN cord-016990-ot1wi3xi 324 12 with with IN cord-016990-ot1wi3xi 324 13 minimal minimal JJ cord-016990-ot1wi3xi 324 14 inflammation inflammation NN cord-016990-ot1wi3xi 324 15 or or CC cord-016990-ot1wi3xi 324 16 overt overt JJ cord-016990-ot1wi3xi 324 17 evidence evidence NN cord-016990-ot1wi3xi 324 18 of of IN cord-016990-ot1wi3xi 324 19 parenchymal parenchymal JJ cord-016990-ot1wi3xi 324 20 injury injury NN cord-016990-ot1wi3xi 324 21 has have VBZ cord-016990-ot1wi3xi 324 22 also also RB cord-016990-ot1wi3xi 324 23 been be VBN cord-016990-ot1wi3xi 324 24 described describe VBN cord-016990-ot1wi3xi 324 25 . . . cord-016990-ot1wi3xi 325 1 128 128 CD cord-016990-ot1wi3xi 325 2 Other other JJ cord-016990-ot1wi3xi 325 3 patterns pattern NNS cord-016990-ot1wi3xi 325 4 include include VBP cord-016990-ot1wi3xi 325 5 multifocal multifocal JJ cord-016990-ot1wi3xi 325 6 lesions lesion NNS cord-016990-ot1wi3xi 325 7 with with IN cord-016990-ot1wi3xi 325 8 mixed mixed JJ cord-016990-ot1wi3xi 325 9 inflammatory inflammatory JJ cord-016990-ot1wi3xi 325 10 cell cell NN cord-016990-ot1wi3xi 325 11 infiltrates infiltrate VBZ cord-016990-ot1wi3xi 325 12 , , , cord-016990-ot1wi3xi 325 13 hemorrhage hemorrhage NN cord-016990-ot1wi3xi 325 14 , , , cord-016990-ot1wi3xi 325 15 necrosis necrosis NN cord-016990-ot1wi3xi 325 16 , , , cord-016990-ot1wi3xi 325 17 and and CC cord-016990-ot1wi3xi 325 18 cytomegalic cytomegalic NN cord-016990-ot1wi3xi 325 19 cells cell NNS cord-016990-ot1wi3xi 325 20 , , , cord-016990-ot1wi3xi 325 21 or or CC cord-016990-ot1wi3xi 325 22 a a DT cord-016990-ot1wi3xi 325 23 diffuse diffuse NN cord-016990-ot1wi3xi 325 24 , , , cord-016990-ot1wi3xi 325 25 predominantly predominantly RB cord-016990-ot1wi3xi 325 26 mononuclear mononuclear JJ cord-016990-ot1wi3xi 325 27 cell cell NN cord-016990-ot1wi3xi 325 28 infiltrate infiltrate NN cord-016990-ot1wi3xi 325 29 , , , cord-016990-ot1wi3xi 325 30 interstitial interstitial JJ cord-016990-ot1wi3xi 325 31 pneumonitis pneumonitis NN cord-016990-ot1wi3xi 325 32 with with IN cord-016990-ot1wi3xi 325 33 intraalveolar intraalveolar NNP cord-016990-ot1wi3xi 325 34 edema edema NN cord-016990-ot1wi3xi 325 35 and and CC cord-016990-ot1wi3xi 325 36 fibrin fibrin NN cord-016990-ot1wi3xi 325 37 deposition deposition NN cord-016990-ot1wi3xi 325 38 , , , cord-016990-ot1wi3xi 325 39 and and CC cord-016990-ot1wi3xi 325 40 diffusely diffusely RB cord-016990-ot1wi3xi 325 41 distributed distribute VBN cord-016990-ot1wi3xi 325 42 cytomegalic cytomegalic NN cord-016990-ot1wi3xi 325 43 cells cell NNS cord-016990-ot1wi3xi 325 44 ( ( -LRB- cord-016990-ot1wi3xi 325 45 Fig Fig NNP cord-016990-ot1wi3xi 325 46 . . . cord-016990-ot1wi3xi 325 47 11 11 CD cord-016990-ot1wi3xi 325 48 .5E).129 .5E).129 NNS cord-016990-ot1wi3xi 325 49 - - : cord-016990-ot1wi3xi 325 50 131 131 CD cord-016990-ot1wi3xi 326 1 The the DT cord-016990-ot1wi3xi 326 2 cytomegalic cytomegalic NN cord-016990-ot1wi3xi 326 3 changes change NNS cord-016990-ot1wi3xi 326 4 of of IN cord-016990-ot1wi3xi 326 5 CMV CMV NNP cord-016990-ot1wi3xi 326 6 - - HYPH cord-016990-ot1wi3xi 326 7 infected infect VBN cord-016990-ot1wi3xi 326 8 cells cell NNS cord-016990-ot1wi3xi 326 9 are be VBP cord-016990-ot1wi3xi 326 10 evident evident JJ cord-016990-ot1wi3xi 326 11 by by IN cord-016990-ot1wi3xi 326 12 standard standard JJ cord-016990-ot1wi3xi 326 13 H&E H&E NNP cord-016990-ot1wi3xi 326 14 staining stain VBG cord-016990-ot1wi3xi 326 15 and and CC cord-016990-ot1wi3xi 326 16 are be VBP cord-016990-ot1wi3xi 326 17 virtually virtually RB cord-016990-ot1wi3xi 326 18 pathognomonic pathognomonic JJ cord-016990-ot1wi3xi 326 19 of of IN cord-016990-ot1wi3xi 326 20 active active JJ cord-016990-ot1wi3xi 326 21 CMV CMV NNP cord-016990-ot1wi3xi 326 22 infection infection NN cord-016990-ot1wi3xi 326 23 . . . cord-016990-ot1wi3xi 327 1 The the DT cord-016990-ot1wi3xi 327 2 cells cell NNS cord-016990-ot1wi3xi 327 3 are be VBP cord-016990-ot1wi3xi 327 4 enlarged enlarge VBN cord-016990-ot1wi3xi 327 5 ( ( -LRB- cord-016990-ot1wi3xi 327 6 25 25 CD cord-016990-ot1wi3xi 327 7 to to IN cord-016990-ot1wi3xi 327 8 40!J 40!j CD cord-016990-ot1wi3xi 327 9 , , , cord-016990-ot1wi3xi 327 10 m m LS cord-016990-ot1wi3xi 327 11 ) ) -RRB- cord-016990-ot1wi3xi 327 12 and and CC cord-016990-ot1wi3xi 327 13 contain contain VBP cord-016990-ot1wi3xi 327 14 amphophilic amphophilic JJ cord-016990-ot1wi3xi 327 15 to to TO cord-016990-ot1wi3xi 327 16 deeply deeply RB cord-016990-ot1wi3xi 327 17 basophilic basophilic NNP cord-016990-ot1wi3xi 327 18 intranuclear intranuclear NNP cord-016990-ot1wi3xi 327 19 and and CC cord-016990-ot1wi3xi 327 20 intracytoplasmic intracytoplasmic JJ cord-016990-ot1wi3xi 327 21 inclusions inclusion NNS cord-016990-ot1wi3xi 327 22 ( ( -LRB- cord-016990-ot1wi3xi 327 23 Fig fig NN cord-016990-ot1wi3xi 327 24 . . . cord-016990-ot1wi3xi 328 1 11 11 CD cord-016990-ot1wi3xi 328 2 .5B .5B NNPS cord-016990-ot1wi3xi 328 3 , , , cord-016990-ot1wi3xi 328 4 E E NNP cord-016990-ot1wi3xi 328 5 ) ) -RRB- cord-016990-ot1wi3xi 328 6 . . . cord-016990-ot1wi3xi 329 1 The the DT cord-016990-ot1wi3xi 329 2 single single JJ cord-016990-ot1wi3xi 329 3 intranuclear intranuclear NN cord-016990-ot1wi3xi 329 4 inclusion inclusion NN cord-016990-ot1wi3xi 329 5 is be VBZ cord-016990-ot1wi3xi 329 6 composed compose VBN cord-016990-ot1wi3xi 329 7 of of IN cord-016990-ot1wi3xi 329 8 viral viral JJ cord-016990-ot1wi3xi 329 9 nucleoprotein nucleoprotein NNP cord-016990-ot1wi3xi 329 10 and and CC cord-016990-ot1wi3xi 329 11 assembled assemble VBN cord-016990-ot1wi3xi 329 12 caps cap NNS cord-016990-ot1wi3xi 329 13 ids id NNS cord-016990-ot1wi3xi 329 14 , , , cord-016990-ot1wi3xi 329 15 and and CC cord-016990-ot1wi3xi 329 16 is be VBZ cord-016990-ot1wi3xi 329 17 a a DT cord-016990-ot1wi3xi 329 18 large large JJ cord-016990-ot1wi3xi 329 19 ( ( -LRB- cord-016990-ot1wi3xi 329 20 up up IN cord-016990-ot1wi3xi 329 21 to to TO cord-016990-ot1wi3xi 329 22 20 20 CD cord-016990-ot1wi3xi 329 23 ! ! . cord-016990-ot1wi3xi 330 1 J J NNP cord-016990-ot1wi3xi 330 2 , , , cord-016990-ot1wi3xi 330 3 m m NNP cord-016990-ot1wi3xi 330 4 ) ) -RRB- cord-016990-ot1wi3xi 330 5 , , , cord-016990-ot1wi3xi 330 6 round round JJ cord-016990-ot1wi3xi 330 7 to to IN cord-016990-ot1wi3xi 330 8 ovoid ovoid JJ cord-016990-ot1wi3xi 330 9 body body NN cord-016990-ot1wi3xi 330 10 with with IN cord-016990-ot1wi3xi 330 11 a a DT cord-016990-ot1wi3xi 330 12 smoothly smoothly RB cord-016990-ot1wi3xi 330 13 contoured contour VBN cord-016990-ot1wi3xi 330 14 border border NN cord-016990-ot1wi3xi 330 15 that that WDT cord-016990-ot1wi3xi 330 16 is be VBZ cord-016990-ot1wi3xi 330 17 generally generally RB cord-016990-ot1wi3xi 330 18 surrounded surround VBN cord-016990-ot1wi3xi 330 19 by by IN cord-016990-ot1wi3xi 330 20 a a DT cord-016990-ot1wi3xi 330 21 clear clear JJ cord-016990-ot1wi3xi 330 22 halo halo NN cord-016990-ot1wi3xi 330 23 that that WDT cord-016990-ot1wi3xi 330 24 gives give VBZ cord-016990-ot1wi3xi 330 25 the the DT cord-016990-ot1wi3xi 330 26 inclusion inclusion NN cord-016990-ot1wi3xi 330 27 a a DT cord-016990-ot1wi3xi 330 28 distinctive distinctive JJ cord-016990-ot1wi3xi 330 29 owl'seye owl'seye CD cord-016990-ot1wi3xi 330 30 appearance appearance NN cord-016990-ot1wi3xi 330 31 . . . cord-016990-ot1wi3xi 331 1 The the DT cord-016990-ot1wi3xi 331 2 host host NN cord-016990-ot1wi3xi 331 3 cell cell NN cord-016990-ot1wi3xi 331 4 nucleolus nucleolus NN cord-016990-ot1wi3xi 331 5 is be VBZ cord-016990-ot1wi3xi 331 6 often often RB cord-016990-ot1wi3xi 331 7 retained retain VBN cord-016990-ot1wi3xi 331 8 in in IN cord-016990-ot1wi3xi 331 9 the the DT cord-016990-ot1wi3xi 331 10 inclusion inclusion NN cord-016990-ot1wi3xi 331 11 . . . cord-016990-ot1wi3xi 332 1 131 131 CD cord-016990-ot1wi3xi 332 2 Cytoplasmic Cytoplasmic NNP cord-016990-ot1wi3xi 332 3 inclusions inclusion NNS cord-016990-ot1wi3xi 332 4 are be VBP cord-016990-ot1wi3xi 332 5 small small JJ cord-016990-ot1wi3xi 332 6 ( ( -LRB- cord-016990-ot1wi3xi 332 7 1 1 CD cord-016990-ot1wi3xi 332 8 to to IN cord-016990-ot1wi3xi 332 9 3!J 3!j CD cord-016990-ot1wi3xi 332 10 , , , cord-016990-ot1wi3xi 332 11 m m NNP cord-016990-ot1wi3xi 332 12 ) ) -RRB- cord-016990-ot1wi3xi 332 13 , , , cord-016990-ot1wi3xi 332 14 granular granular JJ cord-016990-ot1wi3xi 332 15 bodies body NNS cord-016990-ot1wi3xi 332 16 that that WDT cord-016990-ot1wi3xi 332 17 appear appear VBP cord-016990-ot1wi3xi 332 18 after after IN cord-016990-ot1wi3xi 332 19 the the DT cord-016990-ot1wi3xi 332 20 intranuclear intranuclear NN cord-016990-ot1wi3xi 332 21 inclusion inclusion NN cord-016990-ot1wi3xi 332 22 is be VBZ cord-016990-ot1wi3xi 332 23 well well RB cord-016990-ot1wi3xi 332 24 developed developed JJ cord-016990-ot1wi3xi 332 25 and and CC cord-016990-ot1wi3xi 332 26 are be VBP cord-016990-ot1wi3xi 332 27 not not RB cord-016990-ot1wi3xi 332 28 uniformly uniformly RB cord-016990-ot1wi3xi 332 29 present present JJ cord-016990-ot1wi3xi 332 30 in in IN cord-016990-ot1wi3xi 332 31 all all DT cord-016990-ot1wi3xi 332 32 CMV CMV NNP cord-016990-ot1wi3xi 332 33 - - HYPH cord-016990-ot1wi3xi 332 34 infected infect VBN cord-016990-ot1wi3xi 332 35 cells cell NNS cord-016990-ot1wi3xi 332 36 ( ( -LRB- cord-016990-ot1wi3xi 332 37 Fig fig NN cord-016990-ot1wi3xi 332 38 . . . cord-016990-ot1wi3xi 332 39 11 11 CD cord-016990-ot1wi3xi 332 40 .5B .5B . cord-016990-ot1wi3xi 332 41 ) ) -RRB- cord-016990-ot1wi3xi 332 42 . . . cord-016990-ot1wi3xi 333 1 These these DT cord-016990-ot1wi3xi 333 2 inclusions inclusion NNS cord-016990-ot1wi3xi 333 3 represent represent VBP cord-016990-ot1wi3xi 333 4 a a DT cord-016990-ot1wi3xi 333 5 mixture mixture NN cord-016990-ot1wi3xi 333 6 of of IN cord-016990-ot1wi3xi 333 7 virions virion NNS cord-016990-ot1wi3xi 333 8 and and CC cord-016990-ot1wi3xi 333 9 various various JJ cord-016990-ot1wi3xi 333 10 cellular cellular JJ cord-016990-ot1wi3xi 333 11 organelles organelle NNS cord-016990-ot1wi3xi 333 12 , , , cord-016990-ot1wi3xi 333 13 and and CC cord-016990-ot1wi3xi 333 14 increase increase VB cord-016990-ot1wi3xi 333 15 in in IN cord-016990-ot1wi3xi 333 16 size size NN cord-016990-ot1wi3xi 333 17 and and CC cord-016990-ot1wi3xi 333 18 number number NN cord-016990-ot1wi3xi 333 19 as as IN cord-016990-ot1wi3xi 333 20 the the DT cord-016990-ot1wi3xi 333 21 infection infection NN cord-016990-ot1wi3xi 333 22 progresses progress VBZ cord-016990-ot1wi3xi 333 23 . . . cord-016990-ot1wi3xi 334 1 132 132 CD cord-016990-ot1wi3xi 335 1 Unlike unlike IN cord-016990-ot1wi3xi 335 2 the the DT cord-016990-ot1wi3xi 335 3 intranuclear intranuclear NN cord-016990-ot1wi3xi 335 4 inclusion inclusion NN cord-016990-ot1wi3xi 335 5 , , , cord-016990-ot1wi3xi 335 6 the the DT cord-016990-ot1wi3xi 335 7 cytoplasmic cytoplasmic JJ cord-016990-ot1wi3xi 335 8 inclusions inclusion NNS cord-016990-ot1wi3xi 335 9 stain stain VBP cord-016990-ot1wi3xi 335 10 with with IN cord-016990-ot1wi3xi 335 11 periodic periodic JJ cord-016990-ot1wi3xi 335 12 acid acid NN cord-016990-ot1wi3xi 335 13 - - HYPH cord-016990-ot1wi3xi 335 14 Schiff Schiff NNP cord-016990-ot1wi3xi 335 15 stain stain NN cord-016990-ot1wi3xi 335 16 and and CC cord-016990-ot1wi3xi 335 17 are be VBP cord-016990-ot1wi3xi 335 18 deeply deeply RB cord-016990-ot1wi3xi 335 19 argyrophilic argyrophilic JJ cord-016990-ot1wi3xi 335 20 with with IN cord-016990-ot1wi3xi 335 21 Gomori Gomori NNP cord-016990-ot1wi3xi 335 22 's 's POS cord-016990-ot1wi3xi 335 23 methenamine methenamine JJ cord-016990-ot1wi3xi 335 24 silver silver NNP cord-016990-ot1wi3xi 335 25 stain.!33 stain.!33 CD cord-016990-ot1wi3xi 336 1 Cytomegalovirus Cytomegalovirus NNP cord-016990-ot1wi3xi 336 2 pneumonia pneumonia NN cord-016990-ot1wi3xi 336 3 is be VBZ cord-016990-ot1wi3xi 336 4 defined define VBN cord-016990-ot1wi3xi 336 5 by by IN cord-016990-ot1wi3xi 336 6 the the DT cord-016990-ot1wi3xi 336 7 presence presence NN cord-016990-ot1wi3xi 336 8 of of IN cord-016990-ot1wi3xi 336 9 signs sign NNS cord-016990-ot1wi3xi 336 10 or or CC cord-016990-ot1wi3xi 336 11 symptoms symptom NNS cord-016990-ot1wi3xi 336 12 of of IN cord-016990-ot1wi3xi 336 13 pulmonary pulmonary JJ cord-016990-ot1wi3xi 336 14 disease disease NN cord-016990-ot1wi3xi 336 15 combined combine VBN cord-016990-ot1wi3xi 336 16 with with IN cord-016990-ot1wi3xi 336 17 the the DT cord-016990-ot1wi3xi 336 18 detection detection NN cord-016990-ot1wi3xi 336 19 of of IN cord-016990-ot1wi3xi 336 20 CMV CMV NNP cord-016990-ot1wi3xi 336 21 in in IN cord-016990-ot1wi3xi 336 22 bronchoalveolar bronchoalveolar NNP cord-016990-ot1wi3xi 336 23 lavage lavage NNP cord-016990-ot1wi3xi 336 24 ( ( -LRB- cord-016990-ot1wi3xi 336 25 BAL BAL NNP cord-016990-ot1wi3xi 336 26 ) ) -RRB- cord-016990-ot1wi3xi 336 27 fluid fluid NN cord-016990-ot1wi3xi 336 28 or or CC cord-016990-ot1wi3xi 336 29 lung lung NN cord-016990-ot1wi3xi 336 30 tissue tissue NN cord-016990-ot1wi3xi 336 31 samples sample NNS cord-016990-ot1wi3xi 336 32 . . . cord-016990-ot1wi3xi 337 1 In in IN cord-016990-ot1wi3xi 337 2 this this DT cord-016990-ot1wi3xi 337 3 context context NN cord-016990-ot1wi3xi 337 4 , , , cord-016990-ot1wi3xi 337 5 detection detection NN cord-016990-ot1wi3xi 337 6 methods method NNS cord-016990-ot1wi3xi 337 7 that that WDT cord-016990-ot1wi3xi 337 8 support support VBP cord-016990-ot1wi3xi 337 9 this this DT cord-016990-ot1wi3xi 337 10 definition definition NN cord-016990-ot1wi3xi 337 11 include include VBP cord-016990-ot1wi3xi 337 12 virus virus NN cord-016990-ot1wi3xi 337 13 isolation isolation NN cord-016990-ot1wi3xi 337 14 , , , cord-016990-ot1wi3xi 337 15 histopathologic histopathologic NNP cord-016990-ot1wi3xi 337 16 observation observation NN cord-016990-ot1wi3xi 337 17 of of IN cord-016990-ot1wi3xi 337 18 cytomegalic cytomegalic NNP cord-016990-ot1wi3xi 337 19 cells cell NNS cord-016990-ot1wi3xi 337 20 , , , cord-016990-ot1wi3xi 337 21 ISH ISH NNP cord-016990-ot1wi3xi 337 22 , , , cord-016990-ot1wi3xi 337 23 or or CC cord-016990-ot1wi3xi 337 24 IHC IHC NNP cord-016990-ot1wi3xi 337 25 stains stain NNS cord-016990-ot1wi3xi 337 26 ( ( -LRB- cord-016990-ot1wi3xi 337 27 Fig Fig NNP cord-016990-ot1wi3xi 337 28 . . . cord-016990-ot1wi3xi 337 29 11 11 CD cord-016990-ot1wi3xi 337 30 .5F .5F NFP cord-016990-ot1wi3xi 337 31 ) ) -RRB- cord-016990-ot1wi3xi 337 32 . . . cord-016990-ot1wi3xi 338 1 Detection detection NN cord-016990-ot1wi3xi 338 2 by by IN cord-016990-ot1wi3xi 338 3 PCR PCR NNP cord-016990-ot1wi3xi 338 4 alone alone RB cord-016990-ot1wi3xi 338 5 is be VBZ cord-016990-ot1wi3xi 338 6 considered consider VBN cord-016990-ot1wi3xi 338 7 too too RB cord-016990-ot1wi3xi 338 8 sensitive sensitive JJ cord-016990-ot1wi3xi 338 9 for for IN cord-016990-ot1wi3xi 338 10 the the DT cord-016990-ot1wi3xi 338 11 diagnosis diagnosis NN cord-016990-ot1wi3xi 338 12 of of IN cord-016990-ot1wi3xi 338 13 CMV CMV NNP cord-016990-ot1wi3xi 338 14 pneumonia pneumonia NN cord-016990-ot1wi3xi 338 15 and and CC cord-016990-ot1wi3xi 338 16 is be VBZ cord-016990-ot1wi3xi 338 17 insufficient insufficient JJ cord-016990-ot1wi3xi 338 18 for for IN cord-016990-ot1wi3xi 338 19 this this DT cord-016990-ot1wi3xi 338 20 purpose purpose NN cord-016990-ot1wi3xi 338 21 . . . cord-016990-ot1wi3xi 339 1 134 134 CD cord-016990-ot1wi3xi 339 2 Cytomegalovirus Cytomegalovirus NNP cord-016990-ot1wi3xi 339 3 is be VBZ cord-016990-ot1wi3xi 339 4 most most RBS cord-016990-ot1wi3xi 339 5 often often RB cord-016990-ot1wi3xi 339 6 cultured culture VBN cord-016990-ot1wi3xi 339 7 in in IN cord-016990-ot1wi3xi 339 8 human human JJ cord-016990-ot1wi3xi 339 9 diploid diploid JJ cord-016990-ot1wi3xi 339 10 fibroblasts fibroblast NNS cord-016990-ot1wi3xi 339 11 such such JJ cord-016990-ot1wi3xi 339 12 as as IN cord-016990-ot1wi3xi 339 13 human human JJ cord-016990-ot1wi3xi 339 14 embryonic embryonic JJ cord-016990-ot1wi3xi 339 15 lung lung NN cord-016990-ot1wi3xi 339 16 and and CC cord-016990-ot1wi3xi 339 17 human human NN cord-016990-ot1wi3xi 339 18 foreskin foreskin NN cord-016990-ot1wi3xi 339 19 fibroblasts fibroblast NNS cord-016990-ot1wi3xi 339 20 . . . cord-016990-ot1wi3xi 340 1 It -PRON- PRP cord-016990-ot1wi3xi 340 2 grows grow VBZ cord-016990-ot1wi3xi 340 3 slowly slowly RB cord-016990-ot1wi3xi 340 4 in in IN cord-016990-ot1wi3xi 340 5 conventional conventional JJ cord-016990-ot1wi3xi 340 6 cell cell NN cord-016990-ot1wi3xi 340 7 culture culture NN cord-016990-ot1wi3xi 340 8 , , , cord-016990-ot1wi3xi 340 9 and and CC cord-016990-ot1wi3xi 340 10 the the DT cord-016990-ot1wi3xi 340 11 cytopathic cytopathic JJ cord-016990-ot1wi3xi 340 12 effect effect NN cord-016990-ot1wi3xi 340 13 is be VBZ cord-016990-ot1wi3xi 340 14 generally generally RB cord-016990-ot1wi3xi 340 15 not not RB cord-016990-ot1wi3xi 340 16 detected detect VBN cord-016990-ot1wi3xi 340 17 until until IN cord-016990-ot1wi3xi 340 18 the the DT cord-016990-ot1wi3xi 340 19 second second JJ cord-016990-ot1wi3xi 340 20 week week NN cord-016990-ot1wi3xi 340 21 or or CC cord-016990-ot1wi3xi 340 22 longer long JJR cord-016990-ot1wi3xi 340 23 after after IN cord-016990-ot1wi3xi 340 24 inoculation inoculation NN cord-016990-ot1wi3xi 340 25 . . . cord-016990-ot1wi3xi 341 1 For for IN cord-016990-ot1wi3xi 341 2 this this DT cord-016990-ot1wi3xi 341 3 reason reason NN cord-016990-ot1wi3xi 341 4 , , , cord-016990-ot1wi3xi 341 5 a a DT cord-016990-ot1wi3xi 341 6 shell shell NN cord-016990-ot1wi3xi 341 7 vial vial NN cord-016990-ot1wi3xi 341 8 method method NN cord-016990-ot1wi3xi 341 9 using use VBG cord-016990-ot1wi3xi 341 10 centrifugation centrifugation NN cord-016990-ot1wi3xi 341 11 to to TO cord-016990-ot1wi3xi 341 12 enhance enhance VB cord-016990-ot1wi3xi 341 13 infectivity infectivity NN cord-016990-ot1wi3xi 341 14 has have VBZ cord-016990-ot1wi3xi 341 15 become become VBN cord-016990-ot1wi3xi 341 16 the the DT cord-016990-ot1wi3xi 341 17 standard standard JJ cord-016990-ot1wi3xi 341 18 isolation isolation NN cord-016990-ot1wi3xi 341 19 technique technique NN cord-016990-ot1wi3xi 341 20 and and CC cord-016990-ot1wi3xi 341 21 can can MD cord-016990-ot1wi3xi 341 22 usually usually RB cord-016990-ot1wi3xi 341 23 yield yield VB cord-016990-ot1wi3xi 341 24 diagnostic diagnostic JJ cord-016990-ot1wi3xi 341 25 results result NNS cord-016990-ot1wi3xi 341 26 within within IN cord-016990-ot1wi3xi 341 27 48 48 CD cord-016990-ot1wi3xi 341 28 hours hour NNS cord-016990-ot1wi3xi 341 29 . . . cord-016990-ot1wi3xi 342 1 135 135 CD cord-016990-ot1wi3xi 343 1 For for IN cord-016990-ot1wi3xi 343 2 centuries century NNS cord-016990-ot1wi3xi 343 3 , , , cord-016990-ot1wi3xi 343 4 the the DT cord-016990-ot1wi3xi 343 5 term term NN cord-016990-ot1wi3xi 343 6 herpes herpe NNS cord-016990-ot1wi3xi 343 7 , , , cord-016990-ot1wi3xi 343 8 derived derive VBN cord-016990-ot1wi3xi 343 9 from from IN cord-016990-ot1wi3xi 343 10 the the DT cord-016990-ot1wi3xi 343 11 Greek Greek NNP cord-016990-ot1wi3xi 343 12 erpein erpein NN cord-016990-ot1wi3xi 343 13 ( ( -LRB- cord-016990-ot1wi3xi 343 14 to to TO cord-016990-ot1wi3xi 343 15 crawl crawl VB cord-016990-ot1wi3xi 343 16 ) ) -RRB- cord-016990-ot1wi3xi 343 17 , , , cord-016990-ot1wi3xi 343 18 was be VBD cord-016990-ot1wi3xi 343 19 used use VBN cord-016990-ot1wi3xi 343 20 in in IN cord-016990-ot1wi3xi 343 21 medicine medicine NN cord-016990-ot1wi3xi 343 22 to to TO cord-016990-ot1wi3xi 343 23 describe describe VB cord-016990-ot1wi3xi 343 24 any any DT cord-016990-ot1wi3xi 343 25 spreading spread VBG cord-016990-ot1wi3xi 343 26 cutaneous cutaneous JJ cord-016990-ot1wi3xi 343 27 lesion lesion NN cord-016990-ot1wi3xi 343 28 . . . cord-016990-ot1wi3xi 344 1 By by IN cord-016990-ot1wi3xi 344 2 the the DT cord-016990-ot1wi3xi 344 3 end end NN cord-016990-ot1wi3xi 344 4 of of IN cord-016990-ot1wi3xi 344 5 the the DT cord-016990-ot1wi3xi 344 6 19th 19th JJ cord-016990-ot1wi3xi 344 7 century century NN cord-016990-ot1wi3xi 344 8 , , , cord-016990-ot1wi3xi 344 9 investigators investigator NNS cord-016990-ot1wi3xi 344 10 surmised surmise VBD cord-016990-ot1wi3xi 344 11 that that IN cord-016990-ot1wi3xi 344 12 the the DT cord-016990-ot1wi3xi 344 13 herpetic herpetic JJ cord-016990-ot1wi3xi 344 14 lesions lesion NNS cord-016990-ot1wi3xi 344 15 of of IN cord-016990-ot1wi3xi 344 16 the the DT cord-016990-ot1wi3xi 344 17 lips lip NNS cord-016990-ot1wi3xi 344 18 and and CC cord-016990-ot1wi3xi 344 19 genitalia genitalia NNS cord-016990-ot1wi3xi 344 20 were be VBD cord-016990-ot1wi3xi 344 21 manifestations manifestation NNS cord-016990-ot1wi3xi 344 22 of of IN cord-016990-ot1wi3xi 344 23 a a DT cord-016990-ot1wi3xi 344 24 single single JJ cord-016990-ot1wi3xi 344 25 infectious infectious JJ cord-016990-ot1wi3xi 344 26 agent agent NN cord-016990-ot1wi3xi 344 27 , , , cord-016990-ot1wi3xi 344 28 and and CC cord-016990-ot1wi3xi 344 29 recognized recognize VBD cord-016990-ot1wi3xi 344 30 that that IN cord-016990-ot1wi3xi 344 31 it -PRON- PRP cord-016990-ot1wi3xi 344 32 was be VBD cord-016990-ot1wi3xi 344 33 a a DT cord-016990-ot1wi3xi 344 34 disease disease NN cord-016990-ot1wi3xi 344 35 distinct distinct JJ cord-016990-ot1wi3xi 344 36 from from IN cord-016990-ot1wi3xi 344 37 herpes herpes NNP cord-016990-ot1wi3xi 344 38 zoster zoster NNP cord-016990-ot1wi3xi 344 39 . . . cord-016990-ot1wi3xi 345 1 136.137 136.137 CD cord-016990-ot1wi3xi 346 1 As as IN cord-016990-ot1wi3xi 346 2 with with IN cord-016990-ot1wi3xi 346 3 all all DT cord-016990-ot1wi3xi 346 4 human human JJ cord-016990-ot1wi3xi 346 5 herpesviruses herpesviruse NNS cord-016990-ot1wi3xi 346 6 , , , cord-016990-ot1wi3xi 346 7 HSV HSV NNP cord-016990-ot1wi3xi 346 8 is be VBZ cord-016990-ot1wi3xi 346 9 a a DT cord-016990-ot1wi3xi 346 10 large large JJ cord-016990-ot1wi3xi 346 11 , , , cord-016990-ot1wi3xi 346 12 enveloped envelop VBN cord-016990-ot1wi3xi 346 13 , , , cord-016990-ot1wi3xi 346 14 double double RB cord-016990-ot1wi3xi 346 15 - - HYPH cord-016990-ot1wi3xi 346 16 stranded strand VBN cord-016990-ot1wi3xi 346 17 DNA dna NN cord-016990-ot1wi3xi 346 18 - - HYPH cord-016990-ot1wi3xi 346 19 containing contain VBG cord-016990-ot1wi3xi 346 20 virion virion NN cord-016990-ot1wi3xi 346 21 with with IN cord-016990-ot1wi3xi 346 22 an an DT cord-016990-ot1wi3xi 346 23 icoshedral icoshedral JJ cord-016990-ot1wi3xi 346 24 nucleocapsid nucleocapsid NN cord-016990-ot1wi3xi 346 25 approximately approximately RB cord-016990-ot1wi3xi 346 26 100 100 CD cord-016990-ot1wi3xi 346 27 to to TO cord-016990-ot1wi3xi 346 28 1l0 1l0 CD cord-016990-ot1wi3xi 346 29 nm nm NN cord-016990-ot1wi3xi 346 30 in in IN cord-016990-ot1wi3xi 346 31 diameter diameter NN cord-016990-ot1wi3xi 346 32 , , , cord-016990-ot1wi3xi 346 33 composed compose VBN cord-016990-ot1wi3xi 346 34 of of IN cord-016990-ot1wi3xi 346 35 162 162 CD cord-016990-ot1wi3xi 346 36 cap cap NN cord-016990-ot1wi3xi 346 37 somers somers NNP cord-016990-ot1wi3xi 346 38 . . . cord-016990-ot1wi3xi 347 1 The the DT cord-016990-ot1wi3xi 347 2 nucleocapsid nucleocapsid NN cord-016990-ot1wi3xi 347 3 is be VBZ cord-016990-ot1wi3xi 347 4 surrounded surround VBN cord-016990-ot1wi3xi 347 5 by by IN cord-016990-ot1wi3xi 347 6 an an DT cord-016990-ot1wi3xi 347 7 amorphous amorphous JJ cord-016990-ot1wi3xi 347 8 , , , cord-016990-ot1wi3xi 347 9 sometimes sometimes RB cord-016990-ot1wi3xi 347 10 asymmetric asymmetric JJ cord-016990-ot1wi3xi 347 11 material material NN cord-016990-ot1wi3xi 347 12 ( ( -LRB- cord-016990-ot1wi3xi 347 13 the the DT cord-016990-ot1wi3xi 347 14 tegument tegument NN cord-016990-ot1wi3xi 347 15 ) ) -RRB- cord-016990-ot1wi3xi 347 16 that that WDT cord-016990-ot1wi3xi 347 17 is be VBZ cord-016990-ot1wi3xi 347 18 surrounded surround VBN cord-016990-ot1wi3xi 347 19 by by IN cord-016990-ot1wi3xi 347 20 a a DT cord-016990-ot1wi3xi 347 21 thin thin JJ cord-016990-ot1wi3xi 347 22 , , , cord-016990-ot1wi3xi 347 23 trilaminar trilaminar NN cord-016990-ot1wi3xi 347 24 envelope envelope NN cord-016990-ot1wi3xi 347 25 that that WDT cord-016990-ot1wi3xi 347 26 contains contain VBZ cord-016990-ot1wi3xi 347 27 numerous numerous JJ cord-016990-ot1wi3xi 347 28 glycoprotein glycoprotein NN cord-016990-ot1wi3xi 347 29 spikes spike NNS cord-016990-ot1wi3xi 347 30 ( ( -LRB- cord-016990-ot1wi3xi 347 31 Fig fig NN cord-016990-ot1wi3xi 347 32 . . . cord-016990-ot1wi3xi 347 33 11.1C 11.1c CD cord-016990-ot1wi3xi 347 34 ) ) -RRB- cord-016990-ot1wi3xi 347 35 . . . cord-016990-ot1wi3xi 348 1 The the DT cord-016990-ot1wi3xi 348 2 assembly assembly NN cord-016990-ot1wi3xi 348 3 of of IN cord-016990-ot1wi3xi 348 4 HSV HSV NNP cord-016990-ot1wi3xi 348 5 begins begin VBZ cord-016990-ot1wi3xi 348 6 in in IN cord-016990-ot1wi3xi 348 7 the the DT cord-016990-ot1wi3xi 348 8 nucleus nucleus NN cord-016990-ot1wi3xi 348 9 of of IN cord-016990-ot1wi3xi 348 10 its -PRON- PRP$ cord-016990-ot1wi3xi 348 11 host host NN cord-016990-ot1wi3xi 348 12 cell cell NN cord-016990-ot1wi3xi 348 13 and and CC cord-016990-ot1wi3xi 348 14 the the DT cord-016990-ot1wi3xi 348 15 virus virus NN cord-016990-ot1wi3xi 348 16 acquires acquire VBZ cord-016990-ot1wi3xi 348 17 its -PRON- PRP$ cord-016990-ot1wi3xi 348 18 envelope envelope NN cord-016990-ot1wi3xi 348 19 as as IN cord-016990-ot1wi3xi 348 20 the the DT cord-016990-ot1wi3xi 348 21 capsid capsid NN cord-016990-ot1wi3xi 348 22 buds bud NNS cord-016990-ot1wi3xi 348 23 through through IN cord-016990-ot1wi3xi 348 24 the the DT cord-016990-ot1wi3xi 348 25 inner inner JJ cord-016990-ot1wi3xi 348 26 lamella lamella NN cord-016990-ot1wi3xi 348 27 of of IN cord-016990-ot1wi3xi 348 28 the the DT cord-016990-ot1wi3xi 348 29 nuclear nuclear JJ cord-016990-ot1wi3xi 348 30 membrane.120.l38 membrane.120.l38 NNP cord-016990-ot1wi3xi 348 31 Two two CD cord-016990-ot1wi3xi 348 32 serologic serologic JJ cord-016990-ot1wi3xi 348 33 types type NNS cord-016990-ot1wi3xi 348 34 are be VBP cord-016990-ot1wi3xi 348 35 recognized recognize VBN cord-016990-ot1wi3xi 348 36 and and CC cord-016990-ot1wi3xi 348 37 each each DT cord-016990-ot1wi3xi 348 38 is be VBZ cord-016990-ot1wi3xi 348 39 most most RBS cord-016990-ot1wi3xi 348 40 frequently frequently RB cord-016990-ot1wi3xi 348 41 associated associate VBN cord-016990-ot1wi3xi 348 42 with with IN cord-016990-ot1wi3xi 348 43 particular particular JJ cord-016990-ot1wi3xi 348 44 disease disease NN cord-016990-ot1wi3xi 348 45 syndromes syndrome NNS cord-016990-ot1wi3xi 348 46 ; ; : cord-016990-ot1wi3xi 348 47 however however RB cord-016990-ot1wi3xi 348 48 , , , cord-016990-ot1wi3xi 348 49 either either DT cord-016990-ot1wi3xi 348 50 serotype serotype NN cord-016990-ot1wi3xi 348 51 may may MD cord-016990-ot1wi3xi 348 52 cause cause VB cord-016990-ot1wi3xi 348 53 any any DT cord-016990-ot1wi3xi 348 54 of of IN cord-016990-ot1wi3xi 348 55 the the DT cord-016990-ot1wi3xi 348 56 aggregate aggregate JJ cord-016990-ot1wi3xi 348 57 clinical clinical JJ cord-016990-ot1wi3xi 348 58 syndromes syndrome NNS cord-016990-ot1wi3xi 348 59 . . . cord-016990-ot1wi3xi 349 1 Herpes herpes NN cord-016990-ot1wi3xi 349 2 simplex simplex NN cord-016990-ot1wi3xi 349 3 virus-1 virus-1 NN cord-016990-ot1wi3xi 349 4 causes cause VBZ cord-016990-ot1wi3xi 349 5 gingivostomatitis gingivostomatitis NN cord-016990-ot1wi3xi 349 6 , , , cord-016990-ot1wi3xi 349 7 pharyngitis pharyngitis NN cord-016990-ot1wi3xi 349 8 , , , cord-016990-ot1wi3xi 349 9 esophagitis esophagitis NN cord-016990-ot1wi3xi 349 10 , , , cord-016990-ot1wi3xi 349 11 keratoconjunctivitis keratoconjunctivitis NNP cord-016990-ot1wi3xi 349 12 , , , cord-016990-ot1wi3xi 349 13 and and CC cord-016990-ot1wi3xi 349 14 encephalitis encephalitis NN cord-016990-ot1wi3xi 349 15 , , , cord-016990-ot1wi3xi 349 16 and and CC cord-016990-ot1wi3xi 349 17 is be VBZ cord-016990-ot1wi3xi 349 18 the the DT cord-016990-ot1wi3xi 349 19 serotype serotype NN cord-016990-ot1wi3xi 349 20 most most RBS cord-016990-ot1wi3xi 349 21 commonly commonly RB cord-016990-ot1wi3xi 349 22 associated associate VBN cord-016990-ot1wi3xi 349 23 with with IN cord-016990-ot1wi3xi 349 24 adult adult NN cord-016990-ot1wi3xi 349 25 HSV HSV NNP cord-016990-ot1wi3xi 349 26 pneumonia pneumonia NN cord-016990-ot1wi3xi 349 27 . . . cord-016990-ot1wi3xi 350 1 Herpes Herpes NNP cord-016990-ot1wi3xi 350 2 simplex simplex NNP cord-016990-ot1wi3xi 350 3 virus-2 virus-2 NNP cord-016990-ot1wi3xi 350 4 typically typically RB cord-016990-ot1wi3xi 350 5 infects infect VBZ cord-016990-ot1wi3xi 350 6 genital genital JJ cord-016990-ot1wi3xi 350 7 sites site NNS cord-016990-ot1wi3xi 350 8 such such JJ cord-016990-ot1wi3xi 350 9 as as IN cord-016990-ot1wi3xi 350 10 the the DT cord-016990-ot1wi3xi 350 11 penis penis NN cord-016990-ot1wi3xi 350 12 , , , cord-016990-ot1wi3xi 350 13 urethra urethra NN cord-016990-ot1wi3xi 350 14 , , , cord-016990-ot1wi3xi 350 15 vulva vulva NN cord-016990-ot1wi3xi 350 16 , , , cord-016990-ot1wi3xi 350 17 vagina vagina NN cord-016990-ot1wi3xi 350 18 , , , cord-016990-ot1wi3xi 350 19 and and CC cord-016990-ot1wi3xi 350 20 cervix cervix NN cord-016990-ot1wi3xi 350 21 , , , cord-016990-ot1wi3xi 350 22 and and CC cord-016990-ot1wi3xi 350 23 is be VBZ cord-016990-ot1wi3xi 350 24 the the DT cord-016990-ot1wi3xi 350 25 serotype serotype NN cord-016990-ot1wi3xi 350 26 associated associate VBN cord-016990-ot1wi3xi 350 27 with with IN cord-016990-ot1wi3xi 350 28 approximately approximately RB cord-016990-ot1wi3xi 350 29 80 80 CD cord-016990-ot1wi3xi 350 30 % % NN cord-016990-ot1wi3xi 350 31 of of IN cord-016990-ot1wi3xi 350 32 disseminated disseminate VBN cord-016990-ot1wi3xi 350 33 disease disease NN cord-016990-ot1wi3xi 350 34 and and CC cord-016990-ot1wi3xi 350 35 pulmonary pulmonary JJ cord-016990-ot1wi3xi 350 36 infections infection NNS cord-016990-ot1wi3xi 350 37 in in IN cord-016990-ot1wi3xi 350 38 newborn newborn JJ cord-016990-ot1wi3xi 350 39 infants infant NNS cord-016990-ot1wi3xi 350 40 . . . cord-016990-ot1wi3xi 351 1 136 136 CD cord-016990-ot1wi3xi 352 1 All all DT cord-016990-ot1wi3xi 352 2 herpesviruses herpesviruse NNS cord-016990-ot1wi3xi 352 3 have have VBP cord-016990-ot1wi3xi 352 4 the the DT cord-016990-ot1wi3xi 352 5 ability ability NN cord-016990-ot1wi3xi 352 6 to to TO cord-016990-ot1wi3xi 352 7 persist persist VB cord-016990-ot1wi3xi 352 8 in in IN cord-016990-ot1wi3xi 352 9 an an DT cord-016990-ot1wi3xi 352 10 inactive inactive JJ cord-016990-ot1wi3xi 352 11 state state NN cord-016990-ot1wi3xi 352 12 for for IN cord-016990-ot1wi3xi 352 13 varying vary VBG cord-016990-ot1wi3xi 352 14 periods period NNS cord-016990-ot1wi3xi 352 15 of of IN cord-016990-ot1wi3xi 352 16 time time NN cord-016990-ot1wi3xi 352 17 and and CC cord-016990-ot1wi3xi 352 18 then then RB cord-016990-ot1wi3xi 352 19 recur recur VB cord-016990-ot1wi3xi 352 20 spontaneously spontaneously RB cord-016990-ot1wi3xi 352 21 following follow VBG cord-016990-ot1wi3xi 352 22 undefined undefined JJ cord-016990-ot1wi3xi 352 23 stimuli stimulus NNS cord-016990-ot1wi3xi 352 24 associated associate VBN cord-016990-ot1wi3xi 352 25 with with IN cord-016990-ot1wi3xi 352 26 physical physical JJ cord-016990-ot1wi3xi 352 27 or or CC cord-016990-ot1wi3xi 352 28 emotional emotional JJ cord-016990-ot1wi3xi 352 29 stress stress NN cord-016990-ot1wi3xi 352 30 , , , cord-016990-ot1wi3xi 352 31 trauma trauma NN cord-016990-ot1wi3xi 352 32 to to IN cord-016990-ot1wi3xi 352 33 nerve nerve NN cord-016990-ot1wi3xi 352 34 roots root NNS cord-016990-ot1wi3xi 352 35 or or CC cord-016990-ot1wi3xi 352 36 ganglia ganglion NNS cord-016990-ot1wi3xi 352 37 , , , cord-016990-ot1wi3xi 352 38 fever fever NN cord-016990-ot1wi3xi 352 39 , , , cord-016990-ot1wi3xi 352 40 immunosuppression immunosuppression NN cord-016990-ot1wi3xi 352 41 , , , cord-016990-ot1wi3xi 352 42 or or CC cord-016990-ot1wi3xi 352 43 exposure exposure NN cord-016990-ot1wi3xi 352 44 to to IN cord-016990-ot1wi3xi 352 45 ultraviolet ultraviolet JJ cord-016990-ot1wi3xi 352 46 radiation radiation NN cord-016990-ot1wi3xi 352 47 . . . cord-016990-ot1wi3xi 353 1 138 138 CD cord-016990-ot1wi3xi 354 1 During during IN cord-016990-ot1wi3xi 354 2 the the DT cord-016990-ot1wi3xi 354 3 primary primary JJ cord-016990-ot1wi3xi 354 4 infection infection NN cord-016990-ot1wi3xi 354 5 , , , cord-016990-ot1wi3xi 354 6 HSV HSV NNP cord-016990-ot1wi3xi 354 7 replicates replicate VBZ cord-016990-ot1wi3xi 354 8 at at IN cord-016990-ot1wi3xi 354 9 the the DT cord-016990-ot1wi3xi 354 10 portal portal NN cord-016990-ot1wi3xi 354 11 of of IN cord-016990-ot1wi3xi 354 12 entry entry NN cord-016990-ot1wi3xi 354 13 ( ( -LRB- cord-016990-ot1wi3xi 354 14 typically typically RB cord-016990-ot1wi3xi 354 15 oral oral JJ cord-016990-ot1wi3xi 354 16 or or CC cord-016990-ot1wi3xi 354 17 genital genital JJ cord-016990-ot1wi3xi 354 18 mucosae mucosae NN cord-016990-ot1wi3xi 354 19 ) ) -RRB- cord-016990-ot1wi3xi 354 20 , , , cord-016990-ot1wi3xi 354 21 and and CC cord-016990-ot1wi3xi 354 22 infects infect VBZ cord-016990-ot1wi3xi 354 23 sensory sensory JJ cord-016990-ot1wi3xi 354 24 nerve nerve NN cord-016990-ot1wi3xi 354 25 endings ending NNS cord-016990-ot1wi3xi 354 26 . . . cord-016990-ot1wi3xi 355 1 The the DT cord-016990-ot1wi3xi 355 2 virus virus NN cord-016990-ot1wi3xi 355 3 is be VBZ cord-016990-ot1wi3xi 355 4 transported transport VBN cord-016990-ot1wi3xi 355 5 centripetally centripetally RB cord-016990-ot1wi3xi 355 6 along along IN cord-016990-ot1wi3xi 355 7 peripheral peripheral JJ cord-016990-ot1wi3xi 355 8 sensory sensory JJ cord-016990-ot1wi3xi 355 9 nerves nerve NNS cord-016990-ot1wi3xi 355 10 to to IN cord-016990-ot1wi3xi 355 11 central central JJ cord-016990-ot1wi3xi 355 12 axons axon NNS cord-016990-ot1wi3xi 355 13 and and CC cord-016990-ot1wi3xi 355 14 finally finally RB cord-016990-ot1wi3xi 355 15 to to TO cord-016990-ot1wi3xi 355 16 nerve nerve VB cord-016990-ot1wi3xi 355 17 cell cell NN cord-016990-ot1wi3xi 355 18 bodies body NNS cord-016990-ot1wi3xi 355 19 in in IN cord-016990-ot1wi3xi 355 20 the the DT cord-016990-ot1wi3xi 355 21 trigeminal trigeminal JJ cord-016990-ot1wi3xi 355 22 , , , cord-016990-ot1wi3xi 355 23 sacral sacral JJ cord-016990-ot1wi3xi 355 24 , , , cord-016990-ot1wi3xi 355 25 and and CC cord-016990-ot1wi3xi 355 26 vagal vagal JJ cord-016990-ot1wi3xi 355 27 ganglia ganglion NNS cord-016990-ot1wi3xi 355 28 , , , cord-016990-ot1wi3xi 355 29 where where WRB cord-016990-ot1wi3xi 355 30 it -PRON- PRP cord-016990-ot1wi3xi 355 31 replicates replicate VBZ cord-016990-ot1wi3xi 355 32 briefly briefly RB cord-016990-ot1wi3xi 355 33 before before IN cord-016990-ot1wi3xi 355 34 becoming become VBG cord-016990-ot1wi3xi 355 35 latent.139 latent.139 NNP cord-016990-ot1wi3xi 356 1 -141 -141 : cord-016990-ot1wi3xi 356 2 Antiviral antiviral JJ cord-016990-ot1wi3xi 356 3 drugs drug NNS cord-016990-ot1wi3xi 356 4 have have VBP cord-016990-ot1wi3xi 356 5 no no DT cord-016990-ot1wi3xi 356 6 effect effect NN cord-016990-ot1wi3xi 356 7 on on IN cord-016990-ot1wi3xi 356 8 latent latent JJ cord-016990-ot1wi3xi 356 9 infection infection NN cord-016990-ot1wi3xi 356 10 with with IN cord-016990-ot1wi3xi 356 11 HSV HSV NNP cord-016990-ot1wi3xi 356 12 . . . cord-016990-ot1wi3xi 357 1 Following follow VBG cord-016990-ot1wi3xi 357 2 cues cue NNS cord-016990-ot1wi3xi 357 3 that that WDT cord-016990-ot1wi3xi 357 4 initiate initiate VBP cord-016990-ot1wi3xi 357 5 viral viral JJ cord-016990-ot1wi3xi 357 6 reactivation reactivation NN cord-016990-ot1wi3xi 357 7 , , , cord-016990-ot1wi3xi 357 8 HSV HSV NNP cord-016990-ot1wi3xi 357 9 replicates replicate VBZ cord-016990-ot1wi3xi 357 10 in in IN cord-016990-ot1wi3xi 357 11 sensory sensory JJ cord-016990-ot1wi3xi 357 12 ganglia ganglion NNS cord-016990-ot1wi3xi 357 13 and and CC cord-016990-ot1wi3xi 357 14 is be VBZ cord-016990-ot1wi3xi 357 15 transported transport VBN cord-016990-ot1wi3xi 357 16 centrifugally centrifugally RB cord-016990-ot1wi3xi 357 17 along along IN cord-016990-ot1wi3xi 357 18 sensory sensory JJ cord-016990-ot1wi3xi 357 19 nerves nerve NNS cord-016990-ot1wi3xi 357 20 to to IN cord-016990-ot1wi3xi 357 21 epithelial epithelial JJ cord-016990-ot1wi3xi 357 22 cells cell NNS cord-016990-ot1wi3xi 357 23 on on IN cord-016990-ot1wi3xi 357 24 mucosal mucosal JJ cord-016990-ot1wi3xi 357 25 surfaces surface NNS cord-016990-ot1wi3xi 357 26 . . . cord-016990-ot1wi3xi 358 1 138 138 CD cord-016990-ot1wi3xi 358 2 Reactivation reactivation NN cord-016990-ot1wi3xi 358 3 of of IN cord-016990-ot1wi3xi 358 4 HSV HSV NNP cord-016990-ot1wi3xi 358 5 from from IN cord-016990-ot1wi3xi 358 6 the the DT cord-016990-ot1wi3xi 358 7 trigeminal trigeminal JJ cord-016990-ot1wi3xi 358 8 ganglion ganglion NN cord-016990-ot1wi3xi 358 9 is be VBZ cord-016990-ot1wi3xi 358 10 associated associate VBN cord-016990-ot1wi3xi 358 11 with with IN cord-016990-ot1wi3xi 358 12 asymptomatic asymptomatic JJ cord-016990-ot1wi3xi 358 13 excretion excretion NN cord-016990-ot1wi3xi 358 14 of of IN cord-016990-ot1wi3xi 358 15 virus virus NN cord-016990-ot1wi3xi 358 16 in in IN cord-016990-ot1wi3xi 358 17 saliva saliva NN cord-016990-ot1wi3xi 358 18 , , , cord-016990-ot1wi3xi 358 19 and and CC cord-016990-ot1wi3xi 358 20 with with IN cord-016990-ot1wi3xi 358 21 the the DT cord-016990-ot1wi3xi 358 22 development development NN cord-016990-ot1wi3xi 358 23 of of IN cord-016990-ot1wi3xi 358 24 herpetic herpetic JJ cord-016990-ot1wi3xi 358 25 ulcers ulcer NNS cord-016990-ot1wi3xi 358 26 on on IN cord-016990-ot1wi3xi 358 27 the the DT cord-016990-ot1wi3xi 358 28 vermillion vermillion NN cord-016990-ot1wi3xi 358 29 border border NN cord-016990-ot1wi3xi 358 30 of of IN cord-016990-ot1wi3xi 358 31 the the DT cord-016990-ot1wi3xi 358 32 lip lip NN cord-016990-ot1wi3xi 358 33 , , , cord-016990-ot1wi3xi 358 34 oral oral JJ cord-016990-ot1wi3xi 358 35 mucosa mucosa NN cord-016990-ot1wi3xi 358 36 , , , cord-016990-ot1wi3xi 358 37 or or CC cord-016990-ot1wi3xi 358 38 external external JJ cord-016990-ot1wi3xi 358 39 facial facial JJ cord-016990-ot1wi3xi 358 40 skin skin NN cord-016990-ot1wi3xi 358 41 . . . cord-016990-ot1wi3xi 359 1 142 142 CD cord-016990-ot1wi3xi 359 2 Newborn newborn JJ cord-016990-ot1wi3xi 359 3 infants infant NNS cord-016990-ot1wi3xi 359 4 , , , cord-016990-ot1wi3xi 359 5 severely severely RB cord-016990-ot1wi3xi 359 6 immunosuppressed immunosuppressed JJ cord-016990-ot1wi3xi 359 7 or or CC cord-016990-ot1wi3xi 359 8 burned burn VBD cord-016990-ot1wi3xi 359 9 patients patient NNS cord-016990-ot1wi3xi 359 10 , , , cord-016990-ot1wi3xi 359 11 and and CC cord-016990-ot1wi3xi 359 12 patients patient NNS cord-016990-ot1wi3xi 359 13 with with IN cord-016990-ot1wi3xi 359 14 severe severe JJ cord-016990-ot1wi3xi 359 15 trauma trauma NN cord-016990-ot1wi3xi 359 16 are be VBP cord-016990-ot1wi3xi 359 17 at at IN cord-016990-ot1wi3xi 359 18 greatest great JJS cord-016990-ot1wi3xi 359 19 risk risk NN cord-016990-ot1wi3xi 359 20 of of IN cord-016990-ot1wi3xi 359 21 developing develop VBG cord-016990-ot1wi3xi 359 22 HSV HSV NNP cord-016990-ot1wi3xi 359 23 pneumonia.143 pneumonia.143 NNP cord-016990-ot1wi3xi 359 24 - - : cord-016990-ot1wi3xi 359 25 146 146 CD cord-016990-ot1wi3xi 359 26 Lower lower JJ cord-016990-ot1wi3xi 359 27 respiratory respiratory JJ cord-016990-ot1wi3xi 359 28 tract tract NN cord-016990-ot1wi3xi 359 29 disease disease NN cord-016990-ot1wi3xi 359 30 in in IN cord-016990-ot1wi3xi 359 31 neonates neonate NNS cord-016990-ot1wi3xi 359 32 is be VBZ cord-016990-ot1wi3xi 359 33 most most RBS cord-016990-ot1wi3xi 359 34 commonly commonly RB cord-016990-ot1wi3xi 359 35 associated associate VBN cord-016990-ot1wi3xi 359 36 with with IN cord-016990-ot1wi3xi 359 37 disseminated disseminate VBN cord-016990-ot1wi3xi 359 38 herpetic herpetic JJ cord-016990-ot1wi3xi 359 39 infections infection NNS cord-016990-ot1wi3xi 359 40 . . . cord-016990-ot1wi3xi 360 1 Disseminated disseminate VBN cord-016990-ot1wi3xi 360 2 HSV HSV NNP cord-016990-ot1wi3xi 360 3 infection infection NN cord-016990-ot1wi3xi 360 4 in in IN cord-016990-ot1wi3xi 360 5 the the DT cord-016990-ot1wi3xi 360 6 newborn newborn NN cord-016990-ot1wi3xi 360 7 was be VBD cord-016990-ot1wi3xi 360 8 first first RB cord-016990-ot1wi3xi 360 9 described describe VBN cord-016990-ot1wi3xi 360 10 in in IN cord-016990-ot1wi3xi 360 11 1935 1935 CD cord-016990-ot1wi3xi 360 12 as as IN cord-016990-ot1wi3xi 360 13 " " `` cord-016990-ot1wi3xi 360 14 hepatoadrenal hepatoadrenal JJ cord-016990-ot1wi3xi 360 15 necrosis"147 necrosis"147 NNP cord-016990-ot1wi3xi 360 16 because because IN cord-016990-ot1wi3xi 360 17 of of IN cord-016990-ot1wi3xi 360 18 the the DT cord-016990-ot1wi3xi 360 19 prominent prominent JJ cord-016990-ot1wi3xi 360 20 and and CC cord-016990-ot1wi3xi 360 21 frequent frequent JJ cord-016990-ot1wi3xi 360 22 necroses necrose NNS cord-016990-ot1wi3xi 360 23 that that WDT cord-016990-ot1wi3xi 360 24 occur occur VBP cord-016990-ot1wi3xi 360 25 in in IN cord-016990-ot1wi3xi 360 26 the the DT cord-016990-ot1wi3xi 360 27 livers liver NNS cord-016990-ot1wi3xi 360 28 and and CC cord-016990-ot1wi3xi 360 29 adrenal adrenal JJ cord-016990-ot1wi3xi 360 30 glands gland NNS cord-016990-ot1wi3xi 360 31 of of IN cord-016990-ot1wi3xi 360 32 affected affected JJ cord-016990-ot1wi3xi 360 33 neonates neonate NNS cord-016990-ot1wi3xi 360 34 . . . cord-016990-ot1wi3xi 361 1 148 148 CD cord-016990-ot1wi3xi 361 2 Most Most JJS cord-016990-ot1wi3xi 361 3 cases case NNS cord-016990-ot1wi3xi 361 4 of of IN cord-016990-ot1wi3xi 361 5 neonatal neonatal JJ cord-016990-ot1wi3xi 361 6 disease disease NN cord-016990-ot1wi3xi 361 7 represent represent VBP cord-016990-ot1wi3xi 361 8 primary primary JJ cord-016990-ot1wi3xi 361 9 HSV HSV NNP cord-016990-ot1wi3xi 361 10 infections infection NNS cord-016990-ot1wi3xi 361 11 and and CC cord-016990-ot1wi3xi 361 12 are be VBP cord-016990-ot1wi3xi 361 13 acquired acquire VBN cord-016990-ot1wi3xi 361 14 during during IN cord-016990-ot1wi3xi 361 15 parturition parturition NN cord-016990-ot1wi3xi 361 16 from from IN cord-016990-ot1wi3xi 361 17 HSVinfected hsvinfecte VBN cord-016990-ot1wi3xi 361 18 mothers mother NNS cord-016990-ot1wi3xi 361 19 . . . cord-016990-ot1wi3xi 362 1 The the DT cord-016990-ot1wi3xi 362 2 incidence incidence NN cord-016990-ot1wi3xi 362 3 of of IN cord-016990-ot1wi3xi 362 4 neonatal neonatal JJ cord-016990-ot1wi3xi 362 5 HSV HSV NNP cord-016990-ot1wi3xi 362 6 infection infection NN cord-016990-ot1wi3xi 362 7 is be VBZ cord-016990-ot1wi3xi 362 8 approximately approximately RB cord-016990-ot1wi3xi 362 9 1 1 CD cord-016990-ot1wi3xi 362 10 in in IN cord-016990-ot1wi3xi 362 11 3200 3200 CD cord-016990-ot1wi3xi 362 12 deliveries delivery NNS cord-016990-ot1wi3xi 362 13 , , , cord-016990-ot1wi3xi 362 14 and and CC cord-016990-ot1wi3xi 362 15 disseminated disseminate VBN cord-016990-ot1wi3xi 362 16 disease disease NN cord-016990-ot1wi3xi 362 17 develops develop VBZ cord-016990-ot1wi3xi 362 18 in in IN cord-016990-ot1wi3xi 362 19 approximately approximately RB cord-016990-ot1wi3xi 362 20 25 25 CD cord-016990-ot1wi3xi 362 21 % % NN cord-016990-ot1wi3xi 362 22 of of IN cord-016990-ot1wi3xi 362 23 infected infected JJ cord-016990-ot1wi3xi 362 24 neonates neonate NNS cord-016990-ot1wi3xi 362 25 . . . cord-016990-ot1wi3xi 363 1 149 149 CD cord-016990-ot1wi3xi 364 1 In in IN cord-016990-ot1wi3xi 364 2 disseminated disseminate VBN cord-016990-ot1wi3xi 364 3 infections infection NNS cord-016990-ot1wi3xi 364 4 , , , cord-016990-ot1wi3xi 364 5 signs sign NNS cord-016990-ot1wi3xi 364 6 and and CC cord-016990-ot1wi3xi 364 7 symptoms symptom NNS cord-016990-ot1wi3xi 364 8 appear appear VBP cord-016990-ot1wi3xi 364 9 a a DT cord-016990-ot1wi3xi 364 10 mean mean NN cord-016990-ot1wi3xi 364 11 of of IN cord-016990-ot1wi3xi 364 12 5 5 CD cord-016990-ot1wi3xi 364 13 days day NNS cord-016990-ot1wi3xi 364 14 after after IN cord-016990-ot1wi3xi 364 15 birth birth NN cord-016990-ot1wi3xi 364 16 ( ( -LRB- cord-016990-ot1wi3xi 364 17 range range NN cord-016990-ot1wi3xi 364 18 , , , cord-016990-ot1wi3xi 364 19 0 0 CD cord-016990-ot1wi3xi 364 20 to to TO cord-016990-ot1wi3xi 364 21 12 12 CD cord-016990-ot1wi3xi 364 22 days day NNS cord-016990-ot1wi3xi 364 23 ) ) -RRB- cord-016990-ot1wi3xi 364 24 , , , cord-016990-ot1wi3xi 364 25 and and CC cord-016990-ot1wi3xi 364 26 approximately approximately RB cord-016990-ot1wi3xi 364 27 40 40 CD cord-016990-ot1wi3xi 364 28 % % NN cord-016990-ot1wi3xi 364 29 to to IN cord-016990-ot1wi3xi 364 30 50 50 CD cord-016990-ot1wi3xi 364 31 % % NN cord-016990-ot1wi3xi 364 32 of of IN cord-016990-ot1wi3xi 364 33 these these DT cord-016990-ot1wi3xi 364 34 patients patient NNS cord-016990-ot1wi3xi 364 35 develop develop VBP cord-016990-ot1wi3xi 364 36 pneumonia pneumonia NN cord-016990-ot1wi3xi 364 37 . . . cord-016990-ot1wi3xi 365 1 In in IN cord-016990-ot1wi3xi 365 2 the the DT cord-016990-ot1wi3xi 365 3 pre pre JJ cord-016990-ot1wi3xi 365 4 antiviral antiviral JJ cord-016990-ot1wi3xi 365 5 era era NN cord-016990-ot1wi3xi 365 6 , , , cord-016990-ot1wi3xi 365 7 85 85 CD cord-016990-ot1wi3xi 365 8 % % NN cord-016990-ot1wi3xi 365 9 of of IN cord-016990-ot1wi3xi 365 10 neonates neonate NNS cord-016990-ot1wi3xi 365 11 with with IN cord-016990-ot1wi3xi 365 12 disseminated disseminate VBN cord-016990-ot1wi3xi 365 13 disease disease NN cord-016990-ot1wi3xi 365 14 died die VBD cord-016990-ot1wi3xi 365 15 from from IN cord-016990-ot1wi3xi 365 16 the the DT cord-016990-ot1wi3xi 365 17 infection infection NN cord-016990-ot1wi3xi 365 18 . . . cord-016990-ot1wi3xi 366 1 With with IN cord-016990-ot1wi3xi 366 2 early early JJ cord-016990-ot1wi3xi 366 3 diagnosis diagnosis NN cord-016990-ot1wi3xi 366 4 and and CC cord-016990-ot1wi3xi 366 5 high high JJ cord-016990-ot1wi3xi 366 6 - - HYPH cord-016990-ot1wi3xi 366 7 dose dose NN cord-016990-ot1wi3xi 366 8 acyclovir acyclovir NNP cord-016990-ot1wi3xi 366 9 therapy therapy NN cord-016990-ot1wi3xi 366 10 , , , cord-016990-ot1wi3xi 366 11 mortality mortality NN cord-016990-ot1wi3xi 366 12 has have VBZ cord-016990-ot1wi3xi 366 13 been be VBN cord-016990-ot1wi3xi 366 14 reduced reduce VBN cord-016990-ot1wi3xi 366 15 to to IN cord-016990-ot1wi3xi 366 16 approximately approximately RB cord-016990-ot1wi3xi 366 17 30%?6,138,149 30%?6,138,149 . cord-016990-ot1wi3xi 366 18 The the DT cord-016990-ot1wi3xi 366 19 disease disease NN cord-016990-ot1wi3xi 366 20 can can MD cord-016990-ot1wi3xi 366 21 be be VB cord-016990-ot1wi3xi 366 22 exceedingly exceedingly RB cord-016990-ot1wi3xi 366 23 difficult difficult JJ cord-016990-ot1wi3xi 366 24 to to TO cord-016990-ot1wi3xi 366 25 diagnose diagnose VB cord-016990-ot1wi3xi 366 26 in in IN cord-016990-ot1wi3xi 366 27 a a DT cord-016990-ot1wi3xi 366 28 timely timely JJ cord-016990-ot1wi3xi 366 29 manner manner NN cord-016990-ot1wi3xi 366 30 as as IN cord-016990-ot1wi3xi 366 31 only only RB cord-016990-ot1wi3xi 366 32 10 10 CD cord-016990-ot1wi3xi 366 33 % % NN cord-016990-ot1wi3xi 366 34 of of IN cord-016990-ot1wi3xi 366 35 mothers mother NNS cord-016990-ot1wi3xi 366 36 of of IN cord-016990-ot1wi3xi 366 37 affected affected JJ cord-016990-ot1wi3xi 366 38 infants infant NNS cord-016990-ot1wi3xi 366 39 have have VBP cord-016990-ot1wi3xi 366 40 clinically clinically RB cord-016990-ot1wi3xi 366 41 apparent apparent JJ cord-016990-ot1wi3xi 366 42 HSV HSV NNP cord-016990-ot1wi3xi 366 43 infection infection NN cord-016990-ot1wi3xi 366 44 at at IN cord-016990-ot1wi3xi 366 45 the the DT cord-016990-ot1wi3xi 366 46 time time NN cord-016990-ot1wi3xi 366 47 of of IN cord-016990-ot1wi3xi 366 48 delivery.15o delivery.15o . cord-016990-ot1wi3xi 367 1 Neonates neonate NNS cord-016990-ot1wi3xi 367 2 that that WDT cord-016990-ot1wi3xi 367 3 survive survive VBP cord-016990-ot1wi3xi 367 4 severe severe JJ cord-016990-ot1wi3xi 367 5 disseminated disseminate VBN cord-016990-ot1wi3xi 367 6 disease disease NN cord-016990-ot1wi3xi 367 7 may may MD cord-016990-ot1wi3xi 367 8 develop develop VB cord-016990-ot1wi3xi 367 9 hepatic hepatic JJ cord-016990-ot1wi3xi 367 10 and and CC cord-016990-ot1wi3xi 367 11 adrenal adrenal JJ cord-016990-ot1wi3xi 367 12 calcifications calcification NNS cord-016990-ot1wi3xi 367 13 evident evident JJ cord-016990-ot1wi3xi 367 14 on on IN cord-016990-ot1wi3xi 367 15 abdominal abdominal JJ cord-016990-ot1wi3xi 367 16 radiographs radiograph NNS cord-016990-ot1wi3xi 367 17 . . . cord-016990-ot1wi3xi 368 1 151 151 CD cord-016990-ot1wi3xi 369 1 In in IN cord-016990-ot1wi3xi 369 2 adults adult NNS cord-016990-ot1wi3xi 369 3 , , , cord-016990-ot1wi3xi 369 4 infection infection NN cord-016990-ot1wi3xi 369 5 of of IN cord-016990-ot1wi3xi 369 6 the the DT cord-016990-ot1wi3xi 369 7 respiratory respiratory JJ cord-016990-ot1wi3xi 369 8 tract tract NN cord-016990-ot1wi3xi 369 9 with with IN cord-016990-ot1wi3xi 369 10 HSV HSV NNP cord-016990-ot1wi3xi 369 11 may may MD cord-016990-ot1wi3xi 369 12 be be VB cord-016990-ot1wi3xi 369 13 associated associate VBN cord-016990-ot1wi3xi 369 14 with with IN cord-016990-ot1wi3xi 369 15 disseminated disseminate VBN cord-016990-ot1wi3xi 369 16 herpetic herpetic JJ cord-016990-ot1wi3xi 369 17 infection infection NN cord-016990-ot1wi3xi 369 18 , , , cord-016990-ot1wi3xi 369 19 but but CC cord-016990-ot1wi3xi 369 20 is be VBZ cord-016990-ot1wi3xi 369 21 more more RBR cord-016990-ot1wi3xi 369 22 commonly commonly RB cord-016990-ot1wi3xi 369 23 identified identify VBN cord-016990-ot1wi3xi 369 24 as as IN cord-016990-ot1wi3xi 369 25 an an DT cord-016990-ot1wi3xi 369 26 isolated isolated JJ cord-016990-ot1wi3xi 369 27 disease disease NN cord-016990-ot1wi3xi 369 28 manifestation manifestation NN cord-016990-ot1wi3xi 369 29 resulting result VBG cord-016990-ot1wi3xi 369 30 from from IN cord-016990-ot1wi3xi 369 31 reactivation reactivation NN cord-016990-ot1wi3xi 369 32 of of IN cord-016990-ot1wi3xi 369 33 latent latent JJ cord-016990-ot1wi3xi 369 34 herpetic herpetic JJ cord-016990-ot1wi3xi 369 35 infections infection NNS cord-016990-ot1wi3xi 369 36 in in IN cord-016990-ot1wi3xi 369 37 the the DT cord-016990-ot1wi3xi 369 38 oropharynx oropharynx NN cord-016990-ot1wi3xi 369 39 . . . cord-016990-ot1wi3xi 370 1 Herpetic Herpetic NNP cord-016990-ot1wi3xi 370 2 tracheobronchitis tracheobronchitis NN cord-016990-ot1wi3xi 370 3 is be VBZ cord-016990-ot1wi3xi 370 4 an an DT cord-016990-ot1wi3xi 370 5 ulcerative ulcerative JJ cord-016990-ot1wi3xi 370 6 process process NN cord-016990-ot1wi3xi 370 7 characterized characterize VBN cord-016990-ot1wi3xi 370 8 by by IN cord-016990-ot1wi3xi 370 9 large large JJ cord-016990-ot1wi3xi 370 10 areas area NNS cord-016990-ot1wi3xi 370 11 of of IN cord-016990-ot1wi3xi 370 12 denuded denude VBN cord-016990-ot1wi3xi 370 13 mucosal mucosal JJ cord-016990-ot1wi3xi 370 14 epithelium epithelium NN cord-016990-ot1wi3xi 370 15 and and CC cord-016990-ot1wi3xi 370 16 fibrinopurulent fibrinopurulent NN cord-016990-ot1wi3xi 370 17 exudate exudate NN cord-016990-ot1wi3xi 370 18 containing contain VBG cord-016990-ot1wi3xi 370 19 necrotic necrotic JJ cord-016990-ot1wi3xi 370 20 cells cell NNS cord-016990-ot1wi3xi 370 21 with with IN cord-016990-ot1wi3xi 370 22 densely densely RB cord-016990-ot1wi3xi 370 23 eosinophilic eosinophilic JJ cord-016990-ot1wi3xi 370 24 cytoplasm cytoplasm NN cord-016990-ot1wi3xi 370 25 . . . cord-016990-ot1wi3xi 371 1 Despite despite IN cord-016990-ot1wi3xi 371 2 extensive extensive JJ cord-016990-ot1wi3xi 371 3 tissue tissue NN cord-016990-ot1wi3xi 371 4 damage damage NN cord-016990-ot1wi3xi 371 5 , , , cord-016990-ot1wi3xi 371 6 cells cell NNS cord-016990-ot1wi3xi 371 7 with with IN cord-016990-ot1wi3xi 371 8 intranuclear intranuclear NN cord-016990-ot1wi3xi 371 9 inclusions inclusion NNS cord-016990-ot1wi3xi 371 10 may may MD cord-016990-ot1wi3xi 371 11 be be VB cord-016990-ot1wi3xi 371 12 sparse sparse JJ cord-016990-ot1wi3xi 371 13 , , , cord-016990-ot1wi3xi 371 14 and and CC cord-016990-ot1wi3xi 371 15 , , , cord-016990-ot1wi3xi 371 16 when when WRB cord-016990-ot1wi3xi 371 17 identified identify VBN cord-016990-ot1wi3xi 371 18 , , , cord-016990-ot1wi3xi 371 19 are be VBP cord-016990-ot1wi3xi 371 20 found find VBN cord-016990-ot1wi3xi 371 21 most most RBS cord-016990-ot1wi3xi 371 22 often often RB cord-016990-ot1wi3xi 371 23 at at IN cord-016990-ot1wi3xi 371 24 the the DT cord-016990-ot1wi3xi 371 25 margins margin NNS cord-016990-ot1wi3xi 371 26 of of IN cord-016990-ot1wi3xi 371 27 the the DT cord-016990-ot1wi3xi 371 28 ulcerated ulcerated JJ cord-016990-ot1wi3xi 371 29 epithelium epithelium NN cord-016990-ot1wi3xi 371 30 or or CC cord-016990-ot1wi3xi 371 31 occasionally occasionally RB cord-016990-ot1wi3xi 371 32 in in IN cord-016990-ot1wi3xi 371 33 the the DT cord-016990-ot1wi3xi 371 34 mucous mucous JJ cord-016990-ot1wi3xi 371 35 glands gland NNS cord-016990-ot1wi3xi 371 36 subjacent subjacent VBP cord-016990-ot1wi3xi 371 37 to to IN cord-016990-ot1wi3xi 371 38 ulcerated ulcerated JJ cord-016990-ot1wi3xi 371 39 surfaces surface NNS cord-016990-ot1wi3xi 371 40 . . . cord-016990-ot1wi3xi 372 1 ls2 ls2 NNP cord-016990-ot1wi3xi 372 2 Aspiration Aspiration NNP cord-016990-ot1wi3xi 372 3 of of IN cord-016990-ot1wi3xi 372 4 viruscontaining viruscontaine VBG cord-016990-ot1wi3xi 372 5 secretions secretion NNS cord-016990-ot1wi3xi 372 6 into into IN cord-016990-ot1wi3xi 372 7 the the DT cord-016990-ot1wi3xi 372 8 lower low JJR cord-016990-ot1wi3xi 372 9 respiratory respiratory JJ cord-016990-ot1wi3xi 372 10 tract tract NN cord-016990-ot1wi3xi 372 11 is be VBZ cord-016990-ot1wi3xi 372 12 believed believe VBN cord-016990-ot1wi3xi 372 13 to to TO cord-016990-ot1wi3xi 372 14 be be VB cord-016990-ot1wi3xi 372 15 the the DT cord-016990-ot1wi3xi 372 16 most most RBS cord-016990-ot1wi3xi 372 17 frequent frequent JJ cord-016990-ot1wi3xi 372 18 cause cause NN cord-016990-ot1wi3xi 372 19 of of IN cord-016990-ot1wi3xi 372 20 pulmonary pulmonary JJ cord-016990-ot1wi3xi 372 21 infection infection NN cord-016990-ot1wi3xi 372 22 with with IN cord-016990-ot1wi3xi 372 23 HSV HSV NNP cord-016990-ot1wi3xi 372 24 ; ; : cord-016990-ot1wi3xi 372 25 however however RB cord-016990-ot1wi3xi 372 26 , , , cord-016990-ot1wi3xi 372 27 oral oral JJ cord-016990-ot1wi3xi 372 28 lesions lesion NNS cord-016990-ot1wi3xi 372 29 may may MD cord-016990-ot1wi3xi 372 30 be be VB cord-016990-ot1wi3xi 372 31 absent absent JJ cord-016990-ot1wi3xi 372 32 in in IN cord-016990-ot1wi3xi 372 33 patients patient NNS cord-016990-ot1wi3xi 372 34 with with IN cord-016990-ot1wi3xi 372 35 herpetic herpetic JJ cord-016990-ot1wi3xi 372 36 laryngotracheobronchitis laryngotracheobronchitis NNP cord-016990-ot1wi3xi 372 37 and and CC cord-016990-ot1wi3xi 372 38 bronchopneumonia bronchopneumonia NN cord-016990-ot1wi3xi 372 39 . . . cord-016990-ot1wi3xi 373 1 153 153 CD cord-016990-ot1wi3xi 373 2 Disease Disease NNP cord-016990-ot1wi3xi 373 3 can can MD cord-016990-ot1wi3xi 373 4 be be VB cord-016990-ot1wi3xi 373 5 also also RB cord-016990-ot1wi3xi 373 6 associated associate VBN cord-016990-ot1wi3xi 373 7 with with IN cord-016990-ot1wi3xi 373 8 airway airway NN cord-016990-ot1wi3xi 373 9 trauma trauma NN cord-016990-ot1wi3xi 373 10 caused cause VBN cord-016990-ot1wi3xi 373 11 by by IN cord-016990-ot1wi3xi 373 12 tracheal tracheal JJ cord-016990-ot1wi3xi 373 13 intubation intubation NN cord-016990-ot1wi3xi 373 14 or or CC cord-016990-ot1wi3xi 373 15 from from IN cord-016990-ot1wi3xi 373 16 hematogenous hematogenous JJ cord-016990-ot1wi3xi 373 17 dissemination dissemination NN cord-016990-ot1wi3xi 373 18 of of IN cord-016990-ot1wi3xi 373 19 HSV HSV NNP cord-016990-ot1wi3xi 373 20 . . . cord-016990-ot1wi3xi 374 1 144 144 CD cord-016990-ot1wi3xi 374 2 , , , cord-016990-ot1wi3xi 374 3 1S2,1S4 1S2,1S4 NNP cord-016990-ot1wi3xi 374 4 Chest chest NN cord-016990-ot1wi3xi 374 5 radiographs radiograph NNS cord-016990-ot1wi3xi 374 6 of of IN cord-016990-ot1wi3xi 374 7 HSV HSV NNP cord-016990-ot1wi3xi 374 8 pneumonia pneumonia NN cord-016990-ot1wi3xi 374 9 generally generally RB cord-016990-ot1wi3xi 374 10 show show VBP cord-016990-ot1wi3xi 374 11 ill ill RB cord-016990-ot1wi3xi 374 12 - - HYPH cord-016990-ot1wi3xi 374 13 defined define VBN cord-016990-ot1wi3xi 374 14 nodular nodular JJ cord-016990-ot1wi3xi 374 15 or or CC cord-016990-ot1wi3xi 374 16 reticular reticular JJ cord-016990-ot1wi3xi 374 17 densities density NNS cord-016990-ot1wi3xi 374 18 of of IN cord-016990-ot1wi3xi 374 19 various various JJ cord-016990-ot1wi3xi 374 20 sizes size NNS cord-016990-ot1wi3xi 374 21 scattered scatter VBN cord-016990-ot1wi3xi 374 22 in in IN cord-016990-ot1wi3xi 374 23 both both DT cord-016990-ot1wi3xi 374 24 lung lung NN cord-016990-ot1wi3xi 374 25 fields field NNS cord-016990-ot1wi3xi 374 26 . . . cord-016990-ot1wi3xi 375 1 During during IN cord-016990-ot1wi3xi 375 2 the the DT cord-016990-ot1wi3xi 375 3 early early JJ cord-016990-ot1wi3xi 375 4 stages stage NNS cord-016990-ot1wi3xi 375 5 of of IN cord-016990-ot1wi3xi 375 6 disease disease NN cord-016990-ot1wi3xi 375 7 , , , cord-016990-ot1wi3xi 375 8 these these DT cord-016990-ot1wi3xi 375 9 nodules nodule NNS cord-016990-ot1wi3xi 375 10 measure measure VBP cord-016990-ot1wi3xi 375 11 2 2 CD cord-016990-ot1wi3xi 375 12 to to TO cord-016990-ot1wi3xi 375 13 5 5 CD cord-016990-ot1wi3xi 375 14 mm mm NNS cord-016990-ot1wi3xi 375 15 and and CC cord-016990-ot1wi3xi 375 16 are be VBP cord-016990-ot1wi3xi 375 17 best well RBS cord-016990-ot1wi3xi 375 18 seen see VBN cord-016990-ot1wi3xi 375 19 in in IN cord-016990-ot1wi3xi 375 20 the the DT cord-016990-ot1wi3xi 375 21 periphery periphery NN cord-016990-ot1wi3xi 375 22 of of IN cord-016990-ot1wi3xi 375 23 the the DT cord-016990-ot1wi3xi 375 24 lungs lung NNS cord-016990-ot1wi3xi 375 25 . . . cord-016990-ot1wi3xi 376 1 As as IN cord-016990-ot1wi3xi 376 2 the the DT cord-016990-ot1wi3xi 376 3 disease disease NN cord-016990-ot1wi3xi 376 4 progresses progress VBZ cord-016990-ot1wi3xi 376 5 , , , cord-016990-ot1wi3xi 376 6 these these DT cord-016990-ot1wi3xi 376 7 lesions lesion NNS cord-016990-ot1wi3xi 376 8 coalesce coalesce VBP cord-016990-ot1wi3xi 376 9 and and CC cord-016990-ot1wi3xi 376 10 enlarge enlarge VB cord-016990-ot1wi3xi 376 11 to to TO cord-016990-ot1wi3xi 376 12 form form VB cord-016990-ot1wi3xi 376 13 more more RBR cord-016990-ot1wi3xi 376 14 extensive extensive JJ cord-016990-ot1wi3xi 376 15 infiltrates infiltrate NNS cord-016990-ot1wi3xi 376 16 . . . cord-016990-ot1wi3xi 377 1 137 137 CD cord-016990-ot1wi3xi 377 2 Herpetic Herpetic NNP cord-016990-ot1wi3xi 377 3 infections infection NNS cord-016990-ot1wi3xi 377 4 of of IN cord-016990-ot1wi3xi 377 5 the the DT cord-016990-ot1wi3xi 377 6 airways airway NNS cord-016990-ot1wi3xi 377 7 and and CC cord-016990-ot1wi3xi 377 8 lung lung NN cord-016990-ot1wi3xi 377 9 are be VBP cord-016990-ot1wi3xi 377 10 characteristically characteristically RB cord-016990-ot1wi3xi 377 11 difficult difficult JJ cord-016990-ot1wi3xi 377 12 to to TO cord-016990-ot1wi3xi 377 13 diagnose diagnose VB cord-016990-ot1wi3xi 377 14 clinically clinically RB cord-016990-ot1wi3xi 377 15 and and CC cord-016990-ot1wi3xi 377 16 HSV HSV NNP cord-016990-ot1wi3xi 377 17 pneumonia pneumonia NN cord-016990-ot1wi3xi 377 18 was be VBD cord-016990-ot1wi3xi 377 19 not not RB cord-016990-ot1wi3xi 377 20 described describe VBN cord-016990-ot1wi3xi 377 21 as as IN cord-016990-ot1wi3xi 377 22 a a DT cord-016990-ot1wi3xi 377 23 distinct distinct JJ cord-016990-ot1wi3xi 377 24 clinical clinical JJ cord-016990-ot1wi3xi 377 25 entity entity NN cord-016990-ot1wi3xi 377 26 until until IN cord-016990-ot1wi3xi 377 27 1949.155 1949.155 CD cord-016990-ot1wi3xi 377 28 Several several JJ cord-016990-ot1wi3xi 377 29 studies study NNS cord-016990-ot1wi3xi 377 30 attest attest VBP cord-016990-ot1wi3xi 377 31 to to IN cord-016990-ot1wi3xi 377 32 the the DT cord-016990-ot1wi3xi 377 33 relative relative JJ cord-016990-ot1wi3xi 377 34 infrequency infrequency NN cord-016990-ot1wi3xi 377 35 with with IN cord-016990-ot1wi3xi 377 36 which which WDT cord-016990-ot1wi3xi 377 37 this this DT cord-016990-ot1wi3xi 377 38 diagnosis diagnosis NN cord-016990-ot1wi3xi 377 39 is be VBZ cord-016990-ot1wi3xi 377 40 considered consider VBN cord-016990-ot1wi3xi 377 41 in in IN cord-016990-ot1wi3xi 377 42 patients patient NNS cord-016990-ot1wi3xi 377 43 with with IN cord-016990-ot1wi3xi 377 44 respiratory respiratory JJ cord-016990-ot1wi3xi 377 45 disease disease NN cord-016990-ot1wi3xi 377 46 . . . cord-016990-ot1wi3xi 378 1 For for IN cord-016990-ot1wi3xi 378 2 example example NN cord-016990-ot1wi3xi 378 3 , , , cord-016990-ot1wi3xi 378 4 none none NN cord-016990-ot1wi3xi 378 5 of of IN cord-016990-ot1wi3xi 378 6 the the DT cord-016990-ot1wi3xi 378 7 15 15 CD cord-016990-ot1wi3xi 378 8 cases case NNS cord-016990-ot1wi3xi 378 9 of of IN cord-016990-ot1wi3xi 378 10 HSV HSV NNP cord-016990-ot1wi3xi 378 11 disease disease NN cord-016990-ot1wi3xi 378 12 of of IN cord-016990-ot1wi3xi 378 13 the the DT cord-016990-ot1wi3xi 378 14 middle middle NN cord-016990-ot1wi3xi 378 15 and and CC cord-016990-ot1wi3xi 378 16 lower low JJR cord-016990-ot1wi3xi 378 17 respiratory respiratory JJ cord-016990-ot1wi3xi 378 18 tract tract NN cord-016990-ot1wi3xi 378 19 identified identify VBN cord-016990-ot1wi3xi 378 20 in in IN cord-016990-ot1wi3xi 378 21 a a DT cord-016990-ot1wi3xi 378 22 review review NN cord-016990-ot1wi3xi 378 23 of of IN cord-016990-ot1wi3xi 378 24 autopsies autopsy NNS cord-016990-ot1wi3xi 378 25 at at IN cord-016990-ot1wi3xi 378 26 Brooke Brooke NNP cord-016990-ot1wi3xi 378 27 Army Army NNP cord-016990-ot1wi3xi 378 28 Medical Medical NNP cord-016990-ot1wi3xi 378 29 Center Center NNP cord-016990-ot1wi3xi 378 30 during during IN cord-016990-ot1wi3xi 378 31 1965 1965 CD cord-016990-ot1wi3xi 378 32 to to IN cord-016990-ot1wi3xi 378 33 1968 1968 CD cord-016990-ot1wi3xi 378 34 were be VBD cord-016990-ot1wi3xi 378 35 suspected suspect VBN cord-016990-ot1wi3xi 378 36 prior prior RB cord-016990-ot1wi3xi 378 37 to to IN cord-016990-ot1wi3xi 378 38 autopsy autopsy NN cord-016990-ot1wi3xi 378 39 . . . cord-016990-ot1wi3xi 379 1 143 143 CD cord-016990-ot1wi3xi 380 1 In in IN cord-016990-ot1wi3xi 380 2 a a DT cord-016990-ot1wi3xi 380 3 1982 1982 CD cord-016990-ot1wi3xi 380 4 review review NN cord-016990-ot1wi3xi 380 5 of of IN cord-016990-ot1wi3xi 380 6 20 20 CD cord-016990-ot1wi3xi 380 7 culture culture NN cord-016990-ot1wi3xi 380 8 - - HYPH cord-016990-ot1wi3xi 380 9 confirmed confirm VBN cord-016990-ot1wi3xi 380 10 cases case NNS cord-016990-ot1wi3xi 380 11 of of IN cord-016990-ot1wi3xi 380 12 HSV HSV NNP cord-016990-ot1wi3xi 380 13 pneumonia pneumonia NN cord-016990-ot1wi3xi 380 14 , , , cord-016990-ot1wi3xi 380 15 none none NN cord-016990-ot1wi3xi 380 16 of of IN cord-016990-ot1wi3xi 380 17 the the DT cord-016990-ot1wi3xi 380 18 patients patient NNS cord-016990-ot1wi3xi 380 19 had have VBD cord-016990-ot1wi3xi 380 20 been be VBN cord-016990-ot1wi3xi 380 21 diagnosed diagnose VBN cord-016990-ot1wi3xi 380 22 prior prior RB cord-016990-ot1wi3xi 380 23 to to IN cord-016990-ot1wi3xi 380 24 death death NN cord-016990-ot1wi3xi 380 25 and and CC cord-016990-ot1wi3xi 380 26 all all DT cord-016990-ot1wi3xi 380 27 16 16 CD cord-016990-ot1wi3xi 380 28 had have VBD cord-016990-ot1wi3xi 380 29 oral oral JJ cord-016990-ot1wi3xi 380 30 herpetic herpetic JJ cord-016990-ot1wi3xi 380 31 lesions lesion NNS cord-016990-ot1wi3xi 380 32 at at IN cord-016990-ot1wi3xi 380 33 the the DT cord-016990-ot1wi3xi 380 34 time time NN cord-016990-ot1wi3xi 380 35 of of IN cord-016990-ot1wi3xi 380 36 death.144 death.144 NN cord-016990-ot1wi3xi 381 1 Recent recent JJ cord-016990-ot1wi3xi 381 2 investigations investigation NNS cord-016990-ot1wi3xi 381 3 also also RB cord-016990-ot1wi3xi 381 4 suggest suggest VBP cord-016990-ot1wi3xi 381 5 that that IN cord-016990-ot1wi3xi 381 6 lower low JJR cord-016990-ot1wi3xi 381 7 respiratory respiratory JJ cord-016990-ot1wi3xi 381 8 tract tract NN cord-016990-ot1wi3xi 381 9 disease disease NN cord-016990-ot1wi3xi 381 10 caused cause VBN cord-016990-ot1wi3xi 381 11 by by IN cord-016990-ot1wi3xi 381 12 HSV HSV NNP cord-016990-ot1wi3xi 381 13 may may MD cord-016990-ot1wi3xi 381 14 be be VB cord-016990-ot1wi3xi 381 15 more more RBR cord-016990-ot1wi3xi 381 16 common common JJ cord-016990-ot1wi3xi 381 17 than than IN cord-016990-ot1wi3xi 381 18 currently currently RB cord-016990-ot1wi3xi 381 19 appreciated appreciate VBN cord-016990-ot1wi3xi 381 20 . . . cord-016990-ot1wi3xi 382 1 In in IN cord-016990-ot1wi3xi 382 2 a a DT cord-016990-ot1wi3xi 382 3 study study NN cord-016990-ot1wi3xi 382 4 from from IN cord-016990-ot1wi3xi 382 5 Sweden Sweden NNP cord-016990-ot1wi3xi 382 6 , , , cord-016990-ot1wi3xi 382 7 HSV HSV NNP cord-016990-ot1wi3xi 382 8 was be VBD cord-016990-ot1wi3xi 382 9 cultured culture VBN cord-016990-ot1wi3xi 382 10 from from IN cord-016990-ot1wi3xi 382 11 pro- pro- NN cord-016990-ot1wi3xi 383 1 A a DT cord-016990-ot1wi3xi 383 2 diagnosis diagnosis NN cord-016990-ot1wi3xi 383 3 of of IN cord-016990-ot1wi3xi 383 4 tracheobronchitis tracheobronchitis NN cord-016990-ot1wi3xi 383 5 and and CC cord-016990-ot1wi3xi 383 6 pneumonia pneumonia NN cord-016990-ot1wi3xi 383 7 is be VBZ cord-016990-ot1wi3xi 383 8 best well RBS cord-016990-ot1wi3xi 383 9 established establish VBN cord-016990-ot1wi3xi 383 10 histologically histologically RB cord-016990-ot1wi3xi 383 11 ( ( -LRB- cord-016990-ot1wi3xi 383 12 Fig Fig NNP cord-016990-ot1wi3xi 383 13 . . . cord-016990-ot1wi3xi 383 14 11.6 11.6 CD cord-016990-ot1wi3xi 383 15 ) ) -RRB- cord-016990-ot1wi3xi 383 16 . . . cord-016990-ot1wi3xi 384 1 Because because IN cord-016990-ot1wi3xi 384 2 lower low JJR cord-016990-ot1wi3xi 384 3 respiratory respiratory JJ cord-016990-ot1wi3xi 384 4 tract tract NN cord-016990-ot1wi3xi 384 5 HSV HSV NNP cord-016990-ot1wi3xi 384 6 infections infection NNS cord-016990-ot1wi3xi 384 7 are be VBP cord-016990-ot1wi3xi 384 8 often often RB cord-016990-ot1wi3xi 384 9 focused focus VBN cord-016990-ot1wi3xi 384 10 in in IN cord-016990-ot1wi3xi 384 11 the the DT cord-016990-ot1wi3xi 384 12 tracheobronchial tracheobronchial JJ cord-016990-ot1wi3xi 384 13 tree tree NN cord-016990-ot1wi3xi 384 14 , , , cord-016990-ot1wi3xi 384 15 open open JJ cord-016990-ot1wi3xi 384 16 lung lung NN cord-016990-ot1wi3xi 384 17 biopsy biopsy NN cord-016990-ot1wi3xi 384 18 may may MD cord-016990-ot1wi3xi 384 19 be be VB cord-016990-ot1wi3xi 384 20 less less RBR cord-016990-ot1wi3xi 384 21 sensitive sensitive JJ cord-016990-ot1wi3xi 384 22 than than IN cord-016990-ot1wi3xi 384 23 bronchoscopy.154 bronchoscopy.154 JJ cord-016990-ot1wi3xi 384 24 Herpetic herpetic JJ cord-016990-ot1wi3xi 384 25 lesions lesion NNS cord-016990-ot1wi3xi 384 26 show show VBP cord-016990-ot1wi3xi 384 27 extensive extensive JJ cord-016990-ot1wi3xi 384 28 necrosis necrosis NN cord-016990-ot1wi3xi 384 29 and and CC cord-016990-ot1wi3xi 384 30 karyorrhectic karyorrhectic JJ cord-016990-ot1wi3xi 384 31 debris debris NN cord-016990-ot1wi3xi 384 32 and and CC cord-016990-ot1wi3xi 384 33 are be VBP cord-016990-ot1wi3xi 384 34 associated associate VBN cord-016990-ot1wi3xi 384 35 with with IN cord-016990-ot1wi3xi 384 36 hemorrhage hemorrhage NN cord-016990-ot1wi3xi 384 37 and and CC cord-016990-ot1wi3xi 384 38 a a DT cord-016990-ot1wi3xi 384 39 sparse sparse JJ cord-016990-ot1wi3xi 384 40 - - HYPH cord-016990-ot1wi3xi 384 41 to to IN cord-016990-ot1wi3xi 384 42 - - HYPH cord-016990-ot1wi3xi 384 43 moderate moderate JJ cord-016990-ot1wi3xi 384 44 neutrophilic neutrophilic NN cord-016990-ot1wi3xi 384 45 infiltrate infiltrate NN cord-016990-ot1wi3xi 384 46 ( ( -LRB- cord-016990-ot1wi3xi 384 47 Fig Fig NNP cord-016990-ot1wi3xi 384 48 . . . cord-016990-ot1wi3xi 384 49 11.6A 11.6a CD cord-016990-ot1wi3xi 384 50 , , , cord-016990-ot1wi3xi 384 51 B B NNP cord-016990-ot1wi3xi 384 52 ) ) -RRB- cord-016990-ot1wi3xi 384 53 . . . cord-016990-ot1wi3xi 385 1 Intranuclear intranuclear NN cord-016990-ot1wi3xi 385 2 inclusions inclusion NNS cord-016990-ot1wi3xi 385 3 are be VBP cord-016990-ot1wi3xi 385 4 best best RB cord-016990-ot1wi3xi 385 5 appreciated appreciate VBN cord-016990-ot1wi3xi 385 6 in in IN cord-016990-ot1wi3xi 385 7 cells cell NNS cord-016990-ot1wi3xi 385 8 at at IN cord-016990-ot1wi3xi 385 9 the the DT cord-016990-ot1wi3xi 385 10 leading leading JJ cord-016990-ot1wi3xi 385 11 edge edge NN cord-016990-ot1wi3xi 385 12 of of IN cord-016990-ot1wi3xi 385 13 necrotic necrotic JJ cord-016990-ot1wi3xi 385 14 foci focus NNS cord-016990-ot1wi3xi 385 15 ( ( -LRB- cord-016990-ot1wi3xi 385 16 Fig fig NN cord-016990-ot1wi3xi 385 17 . . . cord-016990-ot1wi3xi 385 18 11 11 CD cord-016990-ot1wi3xi 385 19 .6B .6B NNS cord-016990-ot1wi3xi 385 20 , , , cord-016990-ot1wi3xi 385 21 C C NNP cord-016990-ot1wi3xi 385 22 ) ) -RRB- cord-016990-ot1wi3xi 385 23 . . . cord-016990-ot1wi3xi 386 1 Inclusions inclusion NNS cord-016990-ot1wi3xi 386 2 appear appear VBP cord-016990-ot1wi3xi 386 3 either either CC cord-016990-ot1wi3xi 386 4 as as RB cord-016990-ot1wi3xi 386 5 homogeneous homogeneous JJ cord-016990-ot1wi3xi 386 6 , , , cord-016990-ot1wi3xi 386 7 amphophilic amphophilic JJ cord-016990-ot1wi3xi 386 8 , , , cord-016990-ot1wi3xi 386 9 and and CC cord-016990-ot1wi3xi 386 10 glassy glassy JJ cord-016990-ot1wi3xi 386 11 ( ( -LRB- cord-016990-ot1wi3xi 386 12 Cowdry cowdry JJ cord-016990-ot1wi3xi 386 13 type type NN cord-016990-ot1wi3xi 386 14 B b NN cord-016990-ot1wi3xi 386 15 inclusions inclusion NNS cord-016990-ot1wi3xi 386 16 ) ) -RRB- cord-016990-ot1wi3xi 386 17 , , , cord-016990-ot1wi3xi 386 18 or or CC cord-016990-ot1wi3xi 386 19 as as RB cord-016990-ot1wi3xi 386 20 eosinophilic eosinophilic JJ cord-016990-ot1wi3xi 386 21 with with IN cord-016990-ot1wi3xi 386 22 a a DT cord-016990-ot1wi3xi 386 23 halo halo NN cord-016990-ot1wi3xi 386 24 separating separate VBG cord-016990-ot1wi3xi 386 25 the the DT cord-016990-ot1wi3xi 386 26 inclusion inclusion NN cord-016990-ot1wi3xi 386 27 from from IN cord-016990-ot1wi3xi 386 28 the the DT cord-016990-ot1wi3xi 386 29 nuclear nuclear JJ cord-016990-ot1wi3xi 386 30 membrane membrane NN cord-016990-ot1wi3xi 386 31 ( ( -LRB- cord-016990-ot1wi3xi 387 1 i.e. i.e. FW cord-016990-ot1wi3xi 387 2 , , , cord-016990-ot1wi3xi 387 3 Cow cow NN cord-016990-ot1wi3xi 387 4 dry dry JJ cord-016990-ot1wi3xi 387 5 type type NN cord-016990-ot1wi3xi 387 6 A a NN cord-016990-ot1wi3xi 387 7 inclusions inclusion NNS cord-016990-ot1wi3xi 387 8 ) ) -RRB- cord-016990-ot1wi3xi 387 9 . . . cord-016990-ot1wi3xi 388 1 158 158 CD cord-016990-ot1wi3xi 389 1 Cowdry cowdry JJ cord-016990-ot1wi3xi 389 2 type type NN cord-016990-ot1wi3xi 389 3 B b NN cord-016990-ot1wi3xi 389 4 inclusions inclusion NNS cord-016990-ot1wi3xi 389 5 contain contain VBP cord-016990-ot1wi3xi 389 6 actively actively RB cord-016990-ot1wi3xi 389 7 replicating replicate VBG cord-016990-ot1wi3xi 389 8 virus virus NN cord-016990-ot1wi3xi 389 9 . . . cord-016990-ot1wi3xi 390 1 Type type VB cord-016990-ot1wi3xi 390 2 A a DT cord-016990-ot1wi3xi 390 3 inclusions inclusion NNS cord-016990-ot1wi3xi 390 4 , , , cord-016990-ot1wi3xi 390 5 considered consider VBN cord-016990-ot1wi3xi 390 6 noninfectious noninfectious JJ cord-016990-ot1wi3xi 390 7 and and CC cord-016990-ot1wi3xi 390 8 devoid devoid JJ cord-016990-ot1wi3xi 390 9 of of IN cord-016990-ot1wi3xi 390 10 viral viral JJ cord-016990-ot1wi3xi 390 11 nucleic nucleic JJ cord-016990-ot1wi3xi 390 12 acid acid NN cord-016990-ot1wi3xi 390 13 or or CC cord-016990-ot1wi3xi 390 14 protein protein NN cord-016990-ot1wi3xi 390 15 , , , cord-016990-ot1wi3xi 390 16 represent represent VBP cord-016990-ot1wi3xi 390 17 the the DT cord-016990-ot1wi3xi 390 18 nuclear nuclear JJ cord-016990-ot1wi3xi 390 19 " " `` cord-016990-ot1wi3xi 390 20 scar scar NN cord-016990-ot1wi3xi 390 21 " " '' cord-016990-ot1wi3xi 390 22 of of IN cord-016990-ot1wi3xi 390 23 HSV HSV NNP cord-016990-ot1wi3xi 390 24 infection infection NN cord-016990-ot1wi3xi 390 25 . . . cord-016990-ot1wi3xi 391 1 136 136 CD cord-016990-ot1wi3xi 391 2 , , , cord-016990-ot1wi3xi 391 3 141 141 CD cord-016990-ot1wi3xi 391 4 Other other JJ cord-016990-ot1wi3xi 391 5 changes change NNS cord-016990-ot1wi3xi 391 6 associated associate VBN cord-016990-ot1wi3xi 391 7 with with IN cord-016990-ot1wi3xi 391 8 HSV HSV NNP cord-016990-ot1wi3xi 391 9 , , , cord-016990-ot1wi3xi 391 10 including include VBG cord-016990-ot1wi3xi 391 11 multi multi JJ cord-016990-ot1wi3xi 391 12 nucleation nucleation NN cord-016990-ot1wi3xi 391 13 and and CC cord-016990-ot1wi3xi 391 14 nuclear nuclear JJ cord-016990-ot1wi3xi 391 15 molding molding NN cord-016990-ot1wi3xi 391 16 , , , cord-016990-ot1wi3xi 391 17 and and CC cord-016990-ot1wi3xi 391 18 ballooning balloon VBG cord-016990-ot1wi3xi 391 19 degeneration degeneration NN cord-016990-ot1wi3xi 391 20 of of IN cord-016990-ot1wi3xi 391 21 the the DT cord-016990-ot1wi3xi 391 22 cytoplasm cytoplasm NN cord-016990-ot1wi3xi 391 23 , , , cord-016990-ot1wi3xi 391 24 are be VBP cord-016990-ot1wi3xi 391 25 more more RBR cord-016990-ot1wi3xi 391 26 frequently frequently RB cord-016990-ot1wi3xi 391 27 associated associate VBN cord-016990-ot1wi3xi 391 28 with with IN cord-016990-ot1wi3xi 391 29 squamous squamous JJ cord-016990-ot1wi3xi 391 30 epithelium epithelium NN cord-016990-ot1wi3xi 391 31 and and CC cord-016990-ot1wi3xi 391 32 are be VBP cord-016990-ot1wi3xi 391 33 seldom seldom RB cord-016990-ot1wi3xi 391 34 encountered encounter VBN cord-016990-ot1wi3xi 391 35 in in IN cord-016990-ot1wi3xi 391 36 the the DT cord-016990-ot1wi3xi 391 37 lung lung NN cord-016990-ot1wi3xi 391 38 . . . cord-016990-ot1wi3xi 392 1 Because because IN cord-016990-ot1wi3xi 392 2 of of IN cord-016990-ot1wi3xi 392 3 the the DT cord-016990-ot1wi3xi 392 4 high high JJ cord-016990-ot1wi3xi 392 5 frequency frequency NN cord-016990-ot1wi3xi 392 6 of of IN cord-016990-ot1wi3xi 392 7 hepatic hepatic JJ cord-016990-ot1wi3xi 392 8 and and CC cord-016990-ot1wi3xi 392 9 adrenal adrenal JJ cord-016990-ot1wi3xi 392 10 involvement involvement NN cord-016990-ot1wi3xi 392 11 with with IN cord-016990-ot1wi3xi 392 12 disseminated disseminate VBN cord-016990-ot1wi3xi 392 13 HSV HSV NNP cord-016990-ot1wi3xi 392 14 infection infection NN cord-016990-ot1wi3xi 392 15 in in IN cord-016990-ot1wi3xi 392 16 young young JJ cord-016990-ot1wi3xi 392 17 children child NNS cord-016990-ot1wi3xi 392 18 ( ( -LRB- cord-016990-ot1wi3xi 392 19 Fig Fig NNP cord-016990-ot1wi3xi 392 20 . . . cord-016990-ot1wi3xi 392 21 11 11 CD cord-016990-ot1wi3xi 392 22 .6F .6F NNP cord-016990-ot1wi3xi 392 23 , , , cord-016990-ot1wi3xi 392 24 G G NNP cord-016990-ot1wi3xi 392 25 ) ) -RRB- cord-016990-ot1wi3xi 392 26 , , , cord-016990-ot1wi3xi 392 27 liver liver NN cord-016990-ot1wi3xi 392 28 biopsy biopsy NN cord-016990-ot1wi3xi 392 29 has have VBZ cord-016990-ot1wi3xi 392 30 been be VBN cord-016990-ot1wi3xi 392 31 suggested suggest VBN cord-016990-ot1wi3xi 392 32 as as IN cord-016990-ot1wi3xi 392 33 a a DT cord-016990-ot1wi3xi 392 34 diagnostic diagnostic JJ cord-016990-ot1wi3xi 392 35 technique technique NN cord-016990-ot1wi3xi 392 36 in in IN cord-016990-ot1wi3xi 392 37 this this DT cord-016990-ot1wi3xi 392 38 patient patient JJ cord-016990-ot1wi3xi 392 39 cohort cohort NN cord-016990-ot1wi3xi 392 40 . . . cord-016990-ot1wi3xi 393 1 148 148 CD cord-016990-ot1wi3xi 394 1 Commercially commercially RB cord-016990-ot1wi3xi 394 2 available available JJ cord-016990-ot1wi3xi 394 3 antibodies antibody NNS cord-016990-ot1wi3xi 394 4 exist exist VBP cord-016990-ot1wi3xi 394 5 for for IN cord-016990-ot1wi3xi 394 6 IHC IHC NNP cord-016990-ot1wi3xi 394 7 detection detection NN cord-016990-ot1wi3xi 394 8 of of IN cord-016990-ot1wi3xi 394 9 HSV HSV NNP cord-016990-ot1wi3xi 394 10 in in IN cord-016990-ot1wi3xi 394 11 tissues tissue NNS cord-016990-ot1wi3xi 394 12 ( ( -LRB- cord-016990-ot1wi3xi 394 13 Fig Fig NNP cord-016990-ot1wi3xi 394 14 . . . cord-016990-ot1wi3xi 394 15 11.6D 11.6d LS cord-016990-ot1wi3xi 394 16 ) ) -RRB- cord-016990-ot1wi3xi 394 17 .ls9 .ls9 . cord-016990-ot1wi3xi 395 1 Virus virus NN cord-016990-ot1wi3xi 395 2 isolation isolation NN cord-016990-ot1wi3xi 395 3 remains remain VBZ cord-016990-ot1wi3xi 395 4 an an DT cord-016990-ot1wi3xi 395 5 important important JJ cord-016990-ot1wi3xi 395 6 diagnostic diagnostic JJ cord-016990-ot1wi3xi 395 7 method method NN cord-016990-ot1wi3xi 395 8 ; ; : cord-016990-ot1wi3xi 395 9 however however RB cord-016990-ot1wi3xi 395 10 , , , cord-016990-ot1wi3xi 395 11 because because IN cord-016990-ot1wi3xi 395 12 HSV HSV NNP cord-016990-ot1wi3xi 395 13 can can MD cord-016990-ot1wi3xi 395 14 be be VB cord-016990-ot1wi3xi 395 15 isolated isolate VBN cord-016990-ot1wi3xi 395 16 from from IN cord-016990-ot1wi3xi 395 17 oropharyngeal oropharyngeal JJ cord-016990-ot1wi3xi 395 18 secretions secretion NNS cord-016990-ot1wi3xi 395 19 and and CC cord-016990-ot1wi3xi 395 20 occasionally occasionally RB cord-016990-ot1wi3xi 395 21 from from IN cord-016990-ot1wi3xi 395 22 the the DT cord-016990-ot1wi3xi 395 23 lower low JJR cord-016990-ot1wi3xi 395 24 respiratory respiratory JJ cord-016990-ot1wi3xi 395 25 tract tract NN cord-016990-ot1wi3xi 395 26 of of IN cord-016990-ot1wi3xi 395 27 patients patient NNS cord-016990-ot1wi3xi 395 28 who who WP cord-016990-ot1wi3xi 395 29 lack lack VBP cord-016990-ot1wi3xi 395 30 overt overt JJ cord-016990-ot1wi3xi 395 31 pulmonary pulmonary JJ cord-016990-ot1wi3xi 395 32 disease disease NN cord-016990-ot1wi3xi 395 33 , , , cord-016990-ot1wi3xi 395 34 virologic virologic NNP cord-016990-ot1wi3xi 395 35 cultures culture NNS cord-016990-ot1wi3xi 395 36 must must MD cord-016990-ot1wi3xi 395 37 be be VB cord-016990-ot1wi3xi 395 38 interpreted interpret VBN cord-016990-ot1wi3xi 395 39 in in IN cord-016990-ot1wi3xi 395 40 the the DT cord-016990-ot1wi3xi 395 41 context context NN cord-016990-ot1wi3xi 395 42 of of IN cord-016990-ot1wi3xi 395 43 complementary complementary JJ cord-016990-ot1wi3xi 395 44 clinical clinical JJ cord-016990-ot1wi3xi 395 45 , , , cord-016990-ot1wi3xi 395 46 radiographic radiographic JJ cord-016990-ot1wi3xi 395 47 , , , cord-016990-ot1wi3xi 395 48 and and CC cord-016990-ot1wi3xi 395 49 histopathologic histopathologic JJ cord-016990-ot1wi3xi 395 50 findings finding NNS cord-016990-ot1wi3xi 395 51 as as RB cord-016990-ot1wi3xi 395 52 much much RB cord-016990-ot1wi3xi 395 53 as as IN cord-016990-ot1wi3xi 395 54 possible possible JJ cord-016990-ot1wi3xi 395 55 . . . cord-016990-ot1wi3xi 396 1 Cell cell NN cord-016990-ot1wi3xi 396 2 culture culture NN cord-016990-ot1wi3xi 396 3 systems system NNS cord-016990-ot1wi3xi 396 4 susceptible susceptible JJ cord-016990-ot1wi3xi 396 5 to to IN cord-016990-ot1wi3xi 396 6 HSV HSV NNP cord-016990-ot1wi3xi 396 7 include include VBP cord-016990-ot1wi3xi 396 8 Vero Vero NNP cord-016990-ot1wi3xi 396 9 cells cell NNS cord-016990-ot1wi3xi 396 10 and and CC cord-016990-ot1wi3xi 396 11 foreskin foreskin NN cord-016990-ot1wi3xi 396 12 fibroblasts fibroblast NNS cord-016990-ot1wi3xi 396 13 . . . cord-016990-ot1wi3xi 397 1 Cytopathic cytopathic JJ cord-016990-ot1wi3xi 397 2 effects effect NNS cord-016990-ot1wi3xi 397 3 generally generally RB cord-016990-ot1wi3xi 397 4 develop develop VBP cord-016990-ot1wi3xi 397 5 within within IN cord-016990-ot1wi3xi 397 6 24 24 CD cord-016990-ot1wi3xi 397 7 to to TO cord-016990-ot1wi3xi 397 8 48 48 CD cord-016990-ot1wi3xi 397 9 hours hour NNS cord-016990-ot1wi3xi 397 10 after after IN cord-016990-ot1wi3xi 397 11 cultures culture NNS cord-016990-ot1wi3xi 397 12 are be VBP cord-016990-ot1wi3xi 397 13 inoculated inoculate VBN cord-016990-ot1wi3xi 397 14 with with IN cord-016990-ot1wi3xi 397 15 infectious infectious JJ cord-016990-ot1wi3xi 397 16 specimens specimen NNS cord-016990-ot1wi3xi 397 17 . . . cord-016990-ot1wi3xi 398 1 Suitable suitable JJ cord-016990-ot1wi3xi 398 2 specimens specimen NNS cord-016990-ot1wi3xi 398 3 include include VBP cord-016990-ot1wi3xi 398 4 scrapings scraping NNS cord-016990-ot1wi3xi 398 5 made make VBN cord-016990-ot1wi3xi 398 6 from from IN cord-016990-ot1wi3xi 398 7 mucocutaneous mucocutaneous JJ cord-016990-ot1wi3xi 398 8 lesions lesion NNS cord-016990-ot1wi3xi 398 9 , , , cord-016990-ot1wi3xi 398 10 tracheobronchial tracheobronchial JJ cord-016990-ot1wi3xi 398 11 aspirates aspirate NNS cord-016990-ot1wi3xi 398 12 , , , cord-016990-ot1wi3xi 398 13 or or CC cord-016990-ot1wi3xi 398 14 BAL bal NN cord-016990-ot1wi3xi 398 15 specimens specimen NNS cord-016990-ot1wi3xi 398 16 . . . cord-016990-ot1wi3xi 399 1 In in IN cord-016990-ot1wi3xi 399 2 infants infant NNS cord-016990-ot1wi3xi 399 3 with with IN cord-016990-ot1wi3xi 399 4 evidence evidence NN cord-016990-ot1wi3xi 399 5 of of IN cord-016990-ot1wi3xi 399 6 hepatitis hepatitis NN cord-016990-ot1wi3xi 399 7 , , , cord-016990-ot1wi3xi 399 8 it -PRON- PRP cord-016990-ot1wi3xi 399 9 may may MD cord-016990-ot1wi3xi 399 10 also also RB cord-016990-ot1wi3xi 399 11 be be VB cord-016990-ot1wi3xi 399 12 useful useful JJ cord-016990-ot1wi3xi 399 13 to to TO cord-016990-ot1wi3xi 399 14 obtain obtain VB cord-016990-ot1wi3xi 399 15 duodenal duodenal JJ cord-016990-ot1wi3xi 399 16 aspirates aspirate NNS cord-016990-ot1wi3xi 399 17 for for IN cord-016990-ot1wi3xi 399 18 HSV HSV NNP cord-016990-ot1wi3xi 399 19 isolation isolation NN cord-016990-ot1wi3xi 399 20 . . . cord-016990-ot1wi3xi 400 1 138 138 CD cord-016990-ot1wi3xi 400 2 Polymerase Polymerase NNP cord-016990-ot1wi3xi 400 3 chain chain NN cord-016990-ot1wi3xi 400 4 reaction reaction NN cord-016990-ot1wi3xi 400 5 methods method NNS cord-016990-ot1wi3xi 400 6 that that WDT cord-016990-ot1wi3xi 400 7 amplify amplify VBP cord-016990-ot1wi3xi 400 8 HSV HSV NNP cord-016990-ot1wi3xi 400 9 DNA dna NN cord-016990-ot1wi3xi 400 10 from from IN cord-016990-ot1wi3xi 400 11 clinical clinical JJ cord-016990-ot1wi3xi 400 12 specimens specimen NNS cord-016990-ot1wi3xi 400 13 , , , cord-016990-ot1wi3xi 400 14 including include VBG cord-016990-ot1wi3xi 400 15 tissue tissue NN cord-016990-ot1wi3xi 400 16 and and CC cord-016990-ot1wi3xi 400 17 blood blood NN cord-016990-ot1wi3xi 400 18 , , , cord-016990-ot1wi3xi 400 19 can can MD cord-016990-ot1wi3xi 400 20 be be VB cord-016990-ot1wi3xi 400 21 particularly particularly RB cord-016990-ot1wi3xi 400 22 useful useful JJ cord-016990-ot1wi3xi 400 23 by by IN cord-016990-ot1wi3xi 400 24 specifically specifically RB cord-016990-ot1wi3xi 400 25 distinguishing distinguish VBG cord-016990-ot1wi3xi 400 26 between between IN cord-016990-ot1wi3xi 400 27 HSV HSV NNP cord-016990-ot1wi3xi 400 28 - - HYPH cord-016990-ot1wi3xi 400 29 l l NN cord-016990-ot1wi3xi 400 30 or or CC cord-016990-ot1wi3xi 400 31 HSV-2 HSV-2 NNP cord-016990-ot1wi3xi 400 32 infections.138,149 infections.138,149 JJ cord-016990-ot1wi3xi 400 33 _SP cord-016990-ot1wi3xi 401 1 Varicella varicella NN cord-016990-ot1wi3xi 401 2 - - HYPH cord-016990-ot1wi3xi 401 3 zoster zoster NN cord-016990-ot1wi3xi 401 4 virus virus NN cord-016990-ot1wi3xi 401 5 ( ( -LRB- cord-016990-ot1wi3xi 401 6 VZV VZV NNP cord-016990-ot1wi3xi 401 7 ) ) -RRB- cord-016990-ot1wi3xi 401 8 , , , cord-016990-ot1wi3xi 401 9 also also RB cord-016990-ot1wi3xi 401 10 known know VBN cord-016990-ot1wi3xi 401 11 as as IN cord-016990-ot1wi3xi 401 12 human human JJ cord-016990-ot1wi3xi 401 13 herpesvirus herpesvirus NN cord-016990-ot1wi3xi 401 14 3 3 CD cord-016990-ot1wi3xi 401 15 ( ( -LRB- cord-016990-ot1wi3xi 401 16 HHV-3 HHV-3 NNP cord-016990-ot1wi3xi 401 17 ) ) -RRB- cord-016990-ot1wi3xi 401 18 , , , cord-016990-ot1wi3xi 401 19 is be VBZ cord-016990-ot1wi3xi 401 20 a a DT cord-016990-ot1wi3xi 401 21 human human JJ cord-016990-ot1wi3xi 401 22 a a DT cord-016990-ot1wi3xi 401 23 - - HYPH cord-016990-ot1wi3xi 401 24 herpesvirus herpesvirus NN cord-016990-ot1wi3xi 401 25 most most RBS cord-016990-ot1wi3xi 401 26 closely closely RB cord-016990-ot1wi3xi 401 27 related related JJ cord-016990-ot1wi3xi 401 28 to to IN cord-016990-ot1wi3xi 401 29 HSV HSV NNP cord-016990-ot1wi3xi 401 30 . . . cord-016990-ot1wi3xi 402 1 It -PRON- PRP cord-016990-ot1wi3xi 402 2 has have VBZ cord-016990-ot1wi3xi 402 3 a a DT cord-016990-ot1wi3xi 402 4 linear linear JJ cord-016990-ot1wi3xi 402 5 , , , cord-016990-ot1wi3xi 402 6 double double RB cord-016990-ot1wi3xi 402 7 - - HYPH cord-016990-ot1wi3xi 402 8 stranded strand VBN cord-016990-ot1wi3xi 402 9 DNA dna NN cord-016990-ot1wi3xi 402 10 genome genome NN cord-016990-ot1wi3xi 402 11 with with IN cord-016990-ot1wi3xi 402 12 approximately approximately RB cord-016990-ot1wi3xi 402 13 125 125 CD cord-016990-ot1wi3xi 402 14 kbp kbp NNS cord-016990-ot1wi3xi 402 15 that that WDT cord-016990-ot1wi3xi 402 16 encodes encode VBZ cord-016990-ot1wi3xi 402 17 more more JJR cord-016990-ot1wi3xi 402 18 than than IN cord-016990-ot1wi3xi 402 19 70 70 CD cord-016990-ot1wi3xi 402 20 proteins protein NNS cord-016990-ot1wi3xi 402 21 . . . cord-016990-ot1wi3xi 403 1 The the DT cord-016990-ot1wi3xi 403 2 icosahedral icosahedral JJ cord-016990-ot1wi3xi 403 3 nucleocapsid nucleocapsid NN cord-016990-ot1wi3xi 403 4 is be VBZ cord-016990-ot1wi3xi 403 5 indistinguishable indistinguishable JJ cord-016990-ot1wi3xi 403 6 in in IN cord-016990-ot1wi3xi 403 7 appearance appearance NN cord-016990-ot1wi3xi 403 8 from from IN cord-016990-ot1wi3xi 403 9 other other JJ cord-016990-ot1wi3xi 403 10 herpes herpes NN cord-016990-ot1wi3xi 403 11 viruses virus NNS cord-016990-ot1wi3xi 403 12 . . . cord-016990-ot1wi3xi 404 1 The the DT cord-016990-ot1wi3xi 404 2 nucleocapsid nucleocapsid NN cord-016990-ot1wi3xi 404 3 and and CC cord-016990-ot1wi3xi 404 4 the the DT cord-016990-ot1wi3xi 404 5 tegument tegument NN cord-016990-ot1wi3xi 404 6 are be VBP cord-016990-ot1wi3xi 404 7 surrounded surround VBN cord-016990-ot1wi3xi 404 8 by by IN cord-016990-ot1wi3xi 404 9 a a DT cord-016990-ot1wi3xi 404 10 lipoprotein lipoprotein NN cord-016990-ot1wi3xi 404 11 envelope envelope NN cord-016990-ot1wi3xi 404 12 derived derive VBN cord-016990-ot1wi3xi 404 13 from from IN cord-016990-ot1wi3xi 404 14 the the DT cord-016990-ot1wi3xi 404 15 host host NN cord-016990-ot1wi3xi 404 16 cytoplasmic cytoplasmic JJ cord-016990-ot1wi3xi 404 17 membranes membrane NNS cord-016990-ot1wi3xi 404 18 . . . cord-016990-ot1wi3xi 405 1 The the DT cord-016990-ot1wi3xi 405 2 enveloped envelop VBN cord-016990-ot1wi3xi 405 3 viral viral JJ cord-016990-ot1wi3xi 405 4 particle particle NN cord-016990-ot1wi3xi 405 5 is be VBZ cord-016990-ot1wi3xi 405 6 pleomorphic pleomorphic JJ cord-016990-ot1wi3xi 405 7 to to TO cord-016990-ot1wi3xi 405 8 spherical spherical JJ cord-016990-ot1wi3xi 405 9 in in IN cord-016990-ot1wi3xi 405 10 shape shape NN cord-016990-ot1wi3xi 405 11 and and CC cord-016990-ot1wi3xi 405 12 180 180 CD cord-016990-ot1wi3xi 405 13 to to TO cord-016990-ot1wi3xi 405 14 200 200 CD cord-016990-ot1wi3xi 405 15 nm nm NN cord-016990-ot1wi3xi 405 16 in in IN cord-016990-ot1wi3xi 405 17 diameter diameter NN cord-016990-ot1wi3xi 405 18 . . . cord-016990-ot1wi3xi 406 1 16o 16o CD cord-016990-ot1wi3xi 407 1 The the DT cord-016990-ot1wi3xi 407 2 primary primary JJ cord-016990-ot1wi3xi 407 3 infection infection NN cord-016990-ot1wi3xi 407 4 is be VBZ cord-016990-ot1wi3xi 407 5 initiated initiate VBN cord-016990-ot1wi3xi 407 6 by by IN cord-016990-ot1wi3xi 407 7 inoculation inoculation NN cord-016990-ot1wi3xi 407 8 of of IN cord-016990-ot1wi3xi 407 9 respiratory respiratory JJ cord-016990-ot1wi3xi 407 10 mucosa mucosa NN cord-016990-ot1wi3xi 407 11 by by IN cord-016990-ot1wi3xi 407 12 the the DT cord-016990-ot1wi3xi 407 13 virus virus NN cord-016990-ot1wi3xi 407 14 through through IN cord-016990-ot1wi3xi 407 15 infectious infectious JJ cord-016990-ot1wi3xi 407 16 aerosols aerosol NNS cord-016990-ot1wi3xi 407 17 or or CC cord-016990-ot1wi3xi 407 18 by by IN cord-016990-ot1wi3xi 407 19 direct direct JJ cord-016990-ot1wi3xi 407 20 contact contact NN cord-016990-ot1wi3xi 407 21 of of IN cord-016990-ot1wi3xi 407 22 skin skin NN cord-016990-ot1wi3xi 407 23 lesions lesion NNS cord-016990-ot1wi3xi 407 24 of of IN cord-016990-ot1wi3xi 407 25 patients patient NNS cord-016990-ot1wi3xi 407 26 with with IN cord-016990-ot1wi3xi 407 27 varicella varicella NN cord-016990-ot1wi3xi 407 28 or or CC cord-016990-ot1wi3xi 407 29 herpes herpes NN cord-016990-ot1wi3xi 407 30 zoster zoster NN cord-016990-ot1wi3xi 407 31 . . . cord-016990-ot1wi3xi 408 1 After after IN cord-016990-ot1wi3xi 408 2 a a DT cord-016990-ot1wi3xi 408 3 primary primary JJ cord-016990-ot1wi3xi 408 4 viremia viremia NN cord-016990-ot1wi3xi 408 5 in in IN cord-016990-ot1wi3xi 408 6 the the DT cord-016990-ot1wi3xi 408 7 reticuloendothelial reticuloendothelial JJ cord-016990-ot1wi3xi 408 8 system system NN cord-016990-ot1wi3xi 408 9 , , , cord-016990-ot1wi3xi 408 10 and and CC cord-016990-ot1wi3xi 408 11 secondary secondary JJ cord-016990-ot1wi3xi 408 12 viremia viremia NN cord-016990-ot1wi3xi 408 13 in in IN cord-016990-ot1wi3xi 408 14 circulating circulate VBG cord-016990-ot1wi3xi 408 15 mononuclear mononuclear JJ cord-016990-ot1wi3xi 408 16 cells cell NNS cord-016990-ot1wi3xi 408 17 , , , cord-016990-ot1wi3xi 408 18 the the DT cord-016990-ot1wi3xi 408 19 virus virus NN cord-016990-ot1wi3xi 408 20 is be VBZ cord-016990-ot1wi3xi 408 21 disseminated disseminate VBN cord-016990-ot1wi3xi 408 22 to to IN cord-016990-ot1wi3xi 408 23 the the DT cord-016990-ot1wi3xi 408 24 skin skin NN cord-016990-ot1wi3xi 408 25 , , , cord-016990-ot1wi3xi 408 26 where where WRB cord-016990-ot1wi3xi 408 27 it -PRON- PRP cord-016990-ot1wi3xi 408 28 initiates initiate VBZ cord-016990-ot1wi3xi 408 29 a a DT cord-016990-ot1wi3xi 408 30 vesicular vesicular JJ cord-016990-ot1wi3xi 408 31 rash rash NN cord-016990-ot1wi3xi 408 32 , , , cord-016990-ot1wi3xi 408 33 and and CC cord-016990-ot1wi3xi 408 34 back back RB cord-016990-ot1wi3xi 408 35 to to IN cord-016990-ot1wi3xi 408 36 mucosal mucosal JJ cord-016990-ot1wi3xi 408 37 sites site NNS cord-016990-ot1wi3xi 408 38 in in IN cord-016990-ot1wi3xi 408 39 the the DT cord-016990-ot1wi3xi 408 40 lungs lung NNS cord-016990-ot1wi3xi 408 41 . . . cord-016990-ot1wi3xi 409 1 The the DT cord-016990-ot1wi3xi 409 2 release release NN cord-016990-ot1wi3xi 409 3 of of IN cord-016990-ot1wi3xi 409 4 infectious infectious JJ cord-016990-ot1wi3xi 409 5 virus virus NN cord-016990-ot1wi3xi 409 6 into into IN cord-016990-ot1wi3xi 409 7 respiratory respiratory JJ cord-016990-ot1wi3xi 409 8 droplets droplet NNS cord-016990-ot1wi3xi 409 9 is be VBZ cord-016990-ot1wi3xi 409 10 a a DT cord-016990-ot1wi3xi 409 11 pathogenic pathogenic JJ cord-016990-ot1wi3xi 409 12 characteristic characteristic NN cord-016990-ot1wi3xi 409 13 that that WDT cord-016990-ot1wi3xi 409 14 distinguishes distinguish VBZ cord-016990-ot1wi3xi 409 15 VZV VZV NNP cord-016990-ot1wi3xi 409 16 from from IN cord-016990-ot1wi3xi 409 17 other other JJ cord-016990-ot1wi3xi 409 18 human human JJ cord-016990-ot1wi3xi 409 19 herpesviruses herpesviruse NNS cord-016990-ot1wi3xi 409 20 . . . cord-016990-ot1wi3xi 410 1 The the DT cord-016990-ot1wi3xi 410 2 attack attack NN cord-016990-ot1wi3xi 410 3 rate rate NN cord-016990-ot1wi3xi 410 4 for for IN cord-016990-ot1wi3xi 410 5 previously previously RB cord-016990-ot1wi3xi 410 6 uninfected uninfected JJ cord-016990-ot1wi3xi 410 7 household household NN cord-016990-ot1wi3xi 410 8 contacts contact NNS cord-016990-ot1wi3xi 410 9 exposed expose VBN cord-016990-ot1wi3xi 410 10 to to IN cord-016990-ot1wi3xi 410 11 varicella varicella NN cord-016990-ot1wi3xi 410 12 is be VBZ cord-016990-ot1wi3xi 410 13 approximately approximately RB cord-016990-ot1wi3xi 410 14 90 90 CD cord-016990-ot1wi3xi 410 15 % % NN cord-016990-ot1wi3xi 410 16 . . . cord-016990-ot1wi3xi 411 1 For for IN cord-016990-ot1wi3xi 411 2 less less RBR cord-016990-ot1wi3xi 411 3 sustained sustained JJ cord-016990-ot1wi3xi 411 4 exposure exposure NN cord-016990-ot1wi3xi 411 5 , , , cord-016990-ot1wi3xi 411 6 it -PRON- PRP cord-016990-ot1wi3xi 411 7 is be VBZ cord-016990-ot1wi3xi 411 8 estimated estimate VBN cord-016990-ot1wi3xi 411 9 to to TO cord-016990-ot1wi3xi 411 10 be be VB cord-016990-ot1wi3xi 411 11 approximately approximately RB cord-016990-ot1wi3xi 411 12 10 10 CD cord-016990-ot1wi3xi 411 13 % % NN cord-016990-ot1wi3xi 411 14 to to TO cord-016990-ot1wi3xi 411 15 30 30 CD cord-016990-ot1wi3xi 411 16 % % NN cord-016990-ot1wi3xi 411 17 . . . cord-016990-ot1wi3xi 412 1 160 160 CD cord-016990-ot1wi3xi 413 1 During during IN cord-016990-ot1wi3xi 413 2 primary primary JJ cord-016990-ot1wi3xi 413 3 infection infection NN cord-016990-ot1wi3xi 413 4 with with IN cord-016990-ot1wi3xi 413 5 VZV VZV NNP cord-016990-ot1wi3xi 413 6 , , , cord-016990-ot1wi3xi 413 7 viral viral JJ cord-016990-ot1wi3xi 413 8 replication replication NN cord-016990-ot1wi3xi 413 9 in in IN cord-016990-ot1wi3xi 413 10 keratinocytes keratinocyte NNS cord-016990-ot1wi3xi 413 11 ( ( -LRB- cord-016990-ot1wi3xi 413 12 Fig Fig NNP cord-016990-ot1wi3xi 413 13 . . . cord-016990-ot1wi3xi 413 14 11.7 11.7 CD cord-016990-ot1wi3xi 413 15 A A NNP cord-016990-ot1wi3xi 413 16 ) ) -RRB- cord-016990-ot1wi3xi 413 17 and and CC cord-016990-ot1wi3xi 413 18 vascular vascular JJ cord-016990-ot1wi3xi 413 19 and and CC cord-016990-ot1wi3xi 413 20 lymphatic lymphatic JJ cord-016990-ot1wi3xi 413 21 endothelial endothelial JJ cord-016990-ot1wi3xi 413 22 cells cell NNS cord-016990-ot1wi3xi 413 23 of of IN cord-016990-ot1wi3xi 413 24 the the DT cord-016990-ot1wi3xi 413 25 superficial superficial JJ cord-016990-ot1wi3xi 413 26 dermis dermis NN cord-016990-ot1wi3xi 413 27 produces produce VBZ cord-016990-ot1wi3xi 413 28 the the DT cord-016990-ot1wi3xi 413 29 generalized generalized JJ cord-016990-ot1wi3xi 413 30 , , , cord-016990-ot1wi3xi 413 31 pruritic pruritic JJ cord-016990-ot1wi3xi 413 32 , , , cord-016990-ot1wi3xi 413 33 vesicular vesicular JJ cord-016990-ot1wi3xi 413 34 rash rash NN cord-016990-ot1wi3xi 413 35 of of IN cord-016990-ot1wi3xi 413 36 varicella varicella NN cord-016990-ot1wi3xi 413 37 commonly commonly RB cord-016990-ot1wi3xi 413 38 known know VBN cord-016990-ot1wi3xi 413 39 as as IN cord-016990-ot1wi3xi 413 40 chickenpox chickenpox NN cord-016990-ot1wi3xi 413 41 . . . cord-016990-ot1wi3xi 414 1 Varicella varicella NN cord-016990-ot1wi3xi 414 2 - - HYPH cord-016990-ot1wi3xi 414 3 zoster zoster NN cord-016990-ot1wi3xi 414 4 virus virus NN cord-016990-ot1wi3xi 414 5 also also RB cord-016990-ot1wi3xi 414 6 establishes establish VBZ cord-016990-ot1wi3xi 414 7 latent latent JJ cord-016990-ot1wi3xi 414 8 infection infection NN cord-016990-ot1wi3xi 414 9 within within IN cord-016990-ot1wi3xi 414 10 satellite satellite NN cord-016990-ot1wi3xi 414 11 cells cell NNS cord-016990-ot1wi3xi 414 12 and and CC cord-016990-ot1wi3xi 414 13 neurons neuron NNS cord-016990-ot1wi3xi 414 14 of of IN cord-016990-ot1wi3xi 414 15 the the DT cord-016990-ot1wi3xi 414 16 trigeminal trigeminal JJ cord-016990-ot1wi3xi 414 17 and and CC cord-016990-ot1wi3xi 414 18 dorsal dorsal JJ cord-016990-ot1wi3xi 414 19 root root NN cord-016990-ot1wi3xi 414 20 ganglia ganglion NNS cord-016990-ot1wi3xi 414 21 and and CC cord-016990-ot1wi3xi 414 22 can can MD cord-016990-ot1wi3xi 414 23 reactivate reactivate VB cord-016990-ot1wi3xi 414 24 under under IN cord-016990-ot1wi3xi 414 25 various various JJ cord-016990-ot1wi3xi 414 26 conditions condition NNS cord-016990-ot1wi3xi 414 27 to to TO cord-016990-ot1wi3xi 414 28 cause cause VB cord-016990-ot1wi3xi 414 29 herpes herpes NNP cord-016990-ot1wi3xi 414 30 zoster zoster NN cord-016990-ot1wi3xi 414 31 , , , cord-016990-ot1wi3xi 414 32 a a DT cord-016990-ot1wi3xi 414 33 painful painful JJ cord-016990-ot1wi3xi 414 34 vesicular vesicular JJ cord-016990-ot1wi3xi 414 35 rash rash NN cord-016990-ot1wi3xi 414 36 commonly commonly RB cord-016990-ot1wi3xi 414 37 referred refer VBD cord-016990-ot1wi3xi 414 38 to to IN cord-016990-ot1wi3xi 414 39 as as IN cord-016990-ot1wi3xi 414 40 shingles shingle NNS cord-016990-ot1wi3xi 414 41 . . . cord-016990-ot1wi3xi 415 1 161 161 CD cord-016990-ot1wi3xi 416 1 The the DT cord-016990-ot1wi3xi 416 2 origin origin NN cord-016990-ot1wi3xi 416 3 of of IN cord-016990-ot1wi3xi 416 4 the the DT cord-016990-ot1wi3xi 416 5 term term NN cord-016990-ot1wi3xi 416 6 chickenpox chickenpox NN cord-016990-ot1wi3xi 416 7 is be VBZ cord-016990-ot1wi3xi 416 8 speCUlative speculative CD cord-016990-ot1wi3xi 416 9 , , , cord-016990-ot1wi3xi 416 10 but but CC cord-016990-ot1wi3xi 416 11 believed believe VBD cord-016990-ot1wi3xi 416 12 to to TO cord-016990-ot1wi3xi 416 13 derive derive VB cord-016990-ot1wi3xi 416 14 from from IN cord-016990-ot1wi3xi 416 15 gican gican NNP cord-016990-ot1wi3xi 416 16 , , , cord-016990-ot1wi3xi 416 17 an an DT cord-016990-ot1wi3xi 416 18 Old Old NNP cord-016990-ot1wi3xi 416 19 English english JJ cord-016990-ot1wi3xi 416 20 term term NN cord-016990-ot1wi3xi 416 21 for for IN cord-016990-ot1wi3xi 416 22 itching itch VBG cord-016990-ot1wi3xi 416 23 . . . cord-016990-ot1wi3xi 417 1 The the DT cord-016990-ot1wi3xi 417 2 term term NN cord-016990-ot1wi3xi 417 3 shingles shingle NNS cord-016990-ot1wi3xi 417 4 originates originate VBZ cord-016990-ot1wi3xi 417 5 from from IN cord-016990-ot1wi3xi 417 6 the the DT cord-016990-ot1wi3xi 417 7 medieval medieval JJ cord-016990-ot1wi3xi 417 8 Latin Latin NNP cord-016990-ot1wi3xi 417 9 cinguls cinguls NN cord-016990-ot1wi3xi 417 10 , , , cord-016990-ot1wi3xi 417 11 or or CC cord-016990-ot1wi3xi 417 12 girdle girdle NN cord-016990-ot1wi3xi 417 13 , , , cord-016990-ot1wi3xi 417 14 and and CC cord-016990-ot1wi3xi 417 15 alludes allude VBZ cord-016990-ot1wi3xi 417 16 to to IN cord-016990-ot1wi3xi 417 17 the the DT cord-016990-ot1wi3xi 417 18 partial partial JJ cord-016990-ot1wi3xi 417 19 encircling encircling NN cord-016990-ot1wi3xi 417 20 of of IN cord-016990-ot1wi3xi 417 21 the the DT cord-016990-ot1wi3xi 417 22 trunk trunk NN cord-016990-ot1wi3xi 417 23 by by IN cord-016990-ot1wi3xi 417 24 the the DT cord-016990-ot1wi3xi 417 25 rash rash NN cord-016990-ot1wi3xi 417 26 of of IN cord-016990-ot1wi3xi 417 27 herpes herpes NNP cord-016990-ot1wi3xi 417 28 zoster zoster NNP cord-016990-ot1wi3xi 417 29 . . . cord-016990-ot1wi3xi 418 1 137 137 CD cord-016990-ot1wi3xi 418 2 , , , cord-016990-ot1wi3xi 418 3 160 160 CD cord-016990-ot1wi3xi 418 4 Varicella varicella NN cord-016990-ot1wi3xi 418 5 - - HYPH cord-016990-ot1wi3xi 418 6 zoster zoster NN cord-016990-ot1wi3xi 418 7 virus virus NN cord-016990-ot1wi3xi 418 8 is be VBZ cord-016990-ot1wi3xi 418 9 ubiquitous ubiquitous JJ cord-016990-ot1wi3xi 418 10 in in IN cord-016990-ot1wi3xi 418 11 human human JJ cord-016990-ot1wi3xi 418 12 populations population NNS cord-016990-ot1wi3xi 418 13 around around IN cord-016990-ot1wi3xi 418 14 the the DT cord-016990-ot1wi3xi 418 15 world world NN cord-016990-ot1wi3xi 418 16 , , , cord-016990-ot1wi3xi 418 17 and and CC cord-016990-ot1wi3xi 418 18 humans human NNS cord-016990-ot1wi3xi 418 19 are be VBP cord-016990-ot1wi3xi 418 20 the the DT cord-016990-ot1wi3xi 418 21 only only RB cord-016990-ot1wi3xi 418 22 known know VBN cord-016990-ot1wi3xi 418 23 host host NN cord-016990-ot1wi3xi 418 24 . . . cord-016990-ot1wi3xi 419 1 During during IN cord-016990-ot1wi3xi 419 2 the the DT cord-016990-ot1wi3xi 419 3 prevaccine prevaccine NN cord-016990-ot1wi3xi 419 4 era era NN cord-016990-ot1wi3xi 419 5 in in IN cord-016990-ot1wi3xi 419 6 the the DT cord-016990-ot1wi3xi 419 7 U.S. U.S. NNP cord-016990-ot1wi3xi 419 8 , , , cord-016990-ot1wi3xi 419 9 approximately approximately RB cord-016990-ot1wi3xi 419 10 4 4 CD cord-016990-ot1wi3xi 419 11 million million CD cord-016990-ot1wi3xi 419 12 cases case NNS cord-016990-ot1wi3xi 419 13 , , , cord-016990-ot1wi3xi 419 14 4000 4000 CD cord-016990-ot1wi3xi 419 15 to to TO cord-016990-ot1wi3xi 419 16 9000 9000 CD cord-016990-ot1wi3xi 419 17 hospitalizations hospitalization NNS cord-016990-ot1wi3xi 419 18 , , , cord-016990-ot1wi3xi 419 19 and and CC cord-016990-ot1wi3xi 419 20 50 50 CD cord-016990-ot1wi3xi 419 21 to to TO cord-016990-ot1wi3xi 419 22 140 140 CD cord-016990-ot1wi3xi 419 23 deaths death NNS cord-016990-ot1wi3xi 419 24 were be VBD cord-016990-ot1wi3xi 419 25 reported report VBN cord-016990-ot1wi3xi 419 26 annually.25.162 annually.25.162 NNP cord-016990-ot1wi3xi 420 1 The the DT cord-016990-ot1wi3xi 420 2 risk risk NN cord-016990-ot1wi3xi 420 3 of of IN cord-016990-ot1wi3xi 420 4 severe severe JJ cord-016990-ot1wi3xi 420 5 illness illness NN cord-016990-ot1wi3xi 420 6 during during IN cord-016990-ot1wi3xi 420 7 primary primary JJ cord-016990-ot1wi3xi 420 8 or or CC cord-016990-ot1wi3xi 420 9 recurrent recurrent JJ cord-016990-ot1wi3xi 420 10 VZV VZV NNP cord-016990-ot1wi3xi 420 11 infection infection NN cord-016990-ot1wi3xi 420 12 appears appear VBZ cord-016990-ot1wi3xi 420 13 to to TO cord-016990-ot1wi3xi 420 14 depend depend VB cord-016990-ot1wi3xi 420 15 more more RBR cord-016990-ot1wi3xi 420 16 on on IN cord-016990-ot1wi3xi 420 17 host host NN cord-016990-ot1wi3xi 420 18 factors factor NNS cord-016990-ot1wi3xi 420 19 rather rather RB cord-016990-ot1wi3xi 420 20 than than IN cord-016990-ot1wi3xi 420 21 a a DT cord-016990-ot1wi3xi 420 22 particular particular JJ cord-016990-ot1wi3xi 420 23 viral viral JJ cord-016990-ot1wi3xi 420 24 strain strain NN cord-016990-ot1wi3xi 420 25 . . . cord-016990-ot1wi3xi 421 1 Chickenpox chickenpox NN cord-016990-ot1wi3xi 421 2 is be VBZ cord-016990-ot1wi3xi 421 3 considered consider VBN cord-016990-ot1wi3xi 421 4 a a DT cord-016990-ot1wi3xi 421 5 relatively relatively RB cord-016990-ot1wi3xi 421 6 benign benign JJ cord-016990-ot1wi3xi 421 7 infection infection NN cord-016990-ot1wi3xi 421 8 in in IN cord-016990-ot1wi3xi 421 9 children child NNS cord-016990-ot1wi3xi 421 10 , , , cord-016990-ot1wi3xi 421 11 but but CC cord-016990-ot1wi3xi 421 12 adult adult NN cord-016990-ot1wi3xi 421 13 patients patient NNS cord-016990-ot1wi3xi 421 14 are be VBP cord-016990-ot1wi3xi 421 15 approximately approximately RB cord-016990-ot1wi3xi 421 16 25 25 CD cord-016990-ot1wi3xi 421 17 times time NNS cord-016990-ot1wi3xi 421 18 more more RBR cord-016990-ot1wi3xi 421 19 likely likely JJ cord-016990-ot1wi3xi 421 20 than than IN cord-016990-ot1wi3xi 421 21 children child NNS cord-016990-ot1wi3xi 421 22 to to TO cord-016990-ot1wi3xi 421 23 develop develop VB cord-016990-ot1wi3xi 421 24 pneumonia pneumonia NN cord-016990-ot1wi3xi 421 25 . . . cord-016990-ot1wi3xi 422 1 The the DT cord-016990-ot1wi3xi 422 2 greatest great JJS cord-016990-ot1wi3xi 422 3 risk risk NN cord-016990-ot1wi3xi 422 4 of of IN cord-016990-ot1wi3xi 422 5 severe severe JJ cord-016990-ot1wi3xi 422 6 disease disease NN cord-016990-ot1wi3xi 422 7 and and CC cord-016990-ot1wi3xi 422 8 pneumonia pneumonia NN cord-016990-ot1wi3xi 422 9 occurs occur VBZ cord-016990-ot1wi3xi 422 10 in in IN cord-016990-ot1wi3xi 422 11 those those DT cord-016990-ot1wi3xi 422 12 patients patient NNS cord-016990-ot1wi3xi 422 13 with with IN cord-016990-ot1wi3xi 422 14 chronic chronic JJ cord-016990-ot1wi3xi 422 15 lung lung NN cord-016990-ot1wi3xi 422 16 disease disease NN cord-016990-ot1wi3xi 422 17 , , , cord-016990-ot1wi3xi 422 18 immunesuppressing immunesuppressing NN cord-016990-ot1wi3xi 422 19 conditions condition NNS cord-016990-ot1wi3xi 422 20 , , , cord-016990-ot1wi3xi 422 21 neonates neonate NNS cord-016990-ot1wi3xi 422 22 , , , cord-016990-ot1wi3xi 422 23 and and CC cord-016990-ot1wi3xi 422 24 pregnant pregnant JJ cord-016990-ot1wi3xi 422 25 women woman NNS cord-016990-ot1wi3xi 422 26 . . . cord-016990-ot1wi3xi 423 1 163 163 CD cord-016990-ot1wi3xi 423 2 Varicella varicella NN cord-016990-ot1wi3xi 423 3 - - HYPH cord-016990-ot1wi3xi 423 4 zoster zoster NN cord-016990-ot1wi3xi 423 5 virus virus NN cord-016990-ot1wi3xi 423 6 - - HYPH cord-016990-ot1wi3xi 423 7 related relate VBN cord-016990-ot1wi3xi 423 8 deaths death NNS cord-016990-ot1wi3xi 423 9 have have VBP cord-016990-ot1wi3xi 423 10 declined decline VBN cord-016990-ot1wi3xi 423 11 sharply sharply RB cord-016990-ot1wi3xi 423 12 in in IN cord-016990-ot1wi3xi 423 13 the the DT cord-016990-ot1wi3xi 423 14 U.S. U.S. NNP cord-016990-ot1wi3xi 423 15 since since IN cord-016990-ot1wi3xi 423 16 universal universal JJ cord-016990-ot1wi3xi 423 17 childhood childhood NN cord-016990-ot1wi3xi 423 18 vaccination vaccination NN cord-016990-ot1wi3xi 423 19 was be VBD cord-016990-ot1wi3xi 423 20 implemented implement VBN cord-016990-ot1wi3xi 423 21 in in IN cord-016990-ot1wi3xi 423 22 1995 1995 CD cord-016990-ot1wi3xi 423 23 . . . cord-016990-ot1wi3xi 424 1 24 24 CD cord-016990-ot1wi3xi 424 2 , , , cord-016990-ot1wi3xi 424 3 25 25 CD cord-016990-ot1wi3xi 424 4 S.R. S.R. NNP cord-016990-ot1wi3xi 424 5 Zaki Zaki NNP cord-016990-ot1wi3xi 424 6 and and CC cord-016990-ot1wi3xi 424 7 CD CD NNP cord-016990-ot1wi3xi 424 8 . . . cord-016990-ot1wi3xi 425 1 Paddock Paddock NNP cord-016990-ot1wi3xi 425 2 Varicella Varicella NNP cord-016990-ot1wi3xi 425 3 pneumonia pneumonia NN cord-016990-ot1wi3xi 425 4 was be VBD cord-016990-ot1wi3xi 425 5 first first RB cord-016990-ot1wi3xi 425 6 described describe VBN cord-016990-ot1wi3xi 425 7 in in IN cord-016990-ot1wi3xi 425 8 the the DT cord-016990-ot1wi3xi 425 9 medical medical JJ cord-016990-ot1wi3xi 425 10 literature literature NN cord-016990-ot1wi3xi 425 11 in in IN cord-016990-ot1wi3xi 425 12 1942 1942 CD cord-016990-ot1wi3xi 425 13 164 164 CD cord-016990-ot1wi3xi 425 14 and and CC cord-016990-ot1wi3xi 425 15 is be VBZ cord-016990-ot1wi3xi 425 16 the the DT cord-016990-ot1wi3xi 425 17 most most RBS cord-016990-ot1wi3xi 425 18 frequently frequently RB cord-016990-ot1wi3xi 425 19 reported report VBN cord-016990-ot1wi3xi 425 20 complication complication NN cord-016990-ot1wi3xi 425 21 of of IN cord-016990-ot1wi3xi 425 22 chickenpox chickenpox NN cord-016990-ot1wi3xi 425 23 in in IN cord-016990-ot1wi3xi 425 24 adult adult NN cord-016990-ot1wi3xi 425 25 patients patient NNS cord-016990-ot1wi3xi 425 26 . . . cord-016990-ot1wi3xi 426 1 24 24 CD cord-016990-ot1wi3xi 426 2 , , , cord-016990-ot1wi3xi 426 3 165 165 CD cord-016990-ot1wi3xi 426 4 Pneumonia pneumonia NN cord-016990-ot1wi3xi 426 5 occurs occur VBZ cord-016990-ot1wi3xi 426 6 in in IN cord-016990-ot1wi3xi 426 7 approximately approximately RB cord-016990-ot1wi3xi 426 8 10 10 CD cord-016990-ot1wi3xi 426 9 % % NN cord-016990-ot1wi3xi 426 10 to to TO cord-016990-ot1wi3xi 426 11 15 15 CD cord-016990-ot1wi3xi 426 12 % % NN cord-016990-ot1wi3xi 426 13 of of IN cord-016990-ot1wi3xi 426 14 adults adult NNS cord-016990-ot1wi3xi 426 15 infected infect VBN cord-016990-ot1wi3xi 426 16 with with IN cord-016990-ot1wi3xi 426 17 VZv VZv NNS cord-016990-ot1wi3xi 426 18 . . . cord-016990-ot1wi3xi 427 1 166 166 CD cord-016990-ot1wi3xi 427 2 , , , cord-016990-ot1wi3xi 427 3 167 167 CD cord-016990-ot1wi3xi 428 1 The the DT cord-016990-ot1wi3xi 428 2 occurrence occurrence NN cord-016990-ot1wi3xi 428 3 of of IN cord-016990-ot1wi3xi 428 4 pneumonia pneumonia NN cord-016990-ot1wi3xi 428 5 during during IN cord-016990-ot1wi3xi 428 6 herpes herpes NNP cord-016990-ot1wi3xi 428 7 zoster zoster NNP cord-016990-ot1wi3xi 428 8 is be VBZ cord-016990-ot1wi3xi 428 9 rare rare JJ cord-016990-ot1wi3xi 428 10 , , , cord-016990-ot1wi3xi 428 11 and and CC cord-016990-ot1wi3xi 428 12 limited limit VBN cord-016990-ot1wi3xi 428 13 primarily primarily RB cord-016990-ot1wi3xi 428 14 to to IN cord-016990-ot1wi3xi 428 15 profoundly profoundly RB cord-016990-ot1wi3xi 428 16 immunosuppressed immunosuppressed JJ cord-016990-ot1wi3xi 428 17 patients patient NNS cord-016990-ot1wi3xi 428 18 , , , cord-016990-ot1wi3xi 428 19 particularly particularly RB cord-016990-ot1wi3xi 428 20 bone bone NN cord-016990-ot1wi3xi 428 21 marrow marrow NN cord-016990-ot1wi3xi 428 22 transplant transplant NN cord-016990-ot1wi3xi 428 23 recipients recipient NNS cord-016990-ot1wi3xi 428 24 . . . cord-016990-ot1wi3xi 429 1 m m NNP cord-016990-ot1wi3xi 429 2 Varicella Varicella NNP cord-016990-ot1wi3xi 429 3 - - HYPH cord-016990-ot1wi3xi 429 4 zoster zoster NN cord-016990-ot1wi3xi 429 5 virus virus NN cord-016990-ot1wi3xi 429 6 pneumonia pneumonia NN cord-016990-ot1wi3xi 429 7 generally generally RB cord-016990-ot1wi3xi 429 8 develops develop VBZ cord-016990-ot1wi3xi 429 9 within within IN cord-016990-ot1wi3xi 429 10 2 2 CD cord-016990-ot1wi3xi 429 11 to to TO cord-016990-ot1wi3xi 429 12 7 7 CD cord-016990-ot1wi3xi 429 13 days day NNS cord-016990-ot1wi3xi 429 14 following follow VBG cord-016990-ot1wi3xi 429 15 the the DT cord-016990-ot1wi3xi 429 16 onset onset NN cord-016990-ot1wi3xi 429 17 of of IN cord-016990-ot1wi3xi 429 18 rash rash NN cord-016990-ot1wi3xi 429 19 and and CC cord-016990-ot1wi3xi 429 20 may may MD cord-016990-ot1wi3xi 429 21 be be VB cord-016990-ot1wi3xi 429 22 characterized characterize VBN cord-016990-ot1wi3xi 429 23 by by IN cord-016990-ot1wi3xi 429 24 fever fever NN cord-016990-ot1wi3xi 429 25 , , , cord-016990-ot1wi3xi 429 26 cough cough NN cord-016990-ot1wi3xi 429 27 , , , cord-016990-ot1wi3xi 429 28 tachypnea tachypnea NNP cord-016990-ot1wi3xi 429 29 , , , cord-016990-ot1wi3xi 429 30 chest chest NN cord-016990-ot1wi3xi 429 31 pain pain NN cord-016990-ot1wi3xi 429 32 , , , cord-016990-ot1wi3xi 429 33 and and CC cord-016990-ot1wi3xi 429 34 hemoptysis hemoptysis NN cord-016990-ot1wi3xi 429 35 . . . cord-016990-ot1wi3xi 430 1 26 26 CD cord-016990-ot1wi3xi 430 2 .168 .168 NFP cord-016990-ot1wi3xi 430 3 Hypoxemia Hypoxemia NNP cord-016990-ot1wi3xi 430 4 is be VBZ cord-016990-ot1wi3xi 430 5 common common JJ cord-016990-ot1wi3xi 430 6 and and CC cord-016990-ot1wi3xi 430 7 may may MD cord-016990-ot1wi3xi 430 8 be be VB cord-016990-ot1wi3xi 430 9 severe severe JJ cord-016990-ot1wi3xi 430 10 . . . cord-016990-ot1wi3xi 431 1 Radiographically Radiographically NNP cord-016990-ot1wi3xi 431 2 , , , cord-016990-ot1wi3xi 431 3 the the DT cord-016990-ot1wi3xi 431 4 lungs lung NNS cord-016990-ot1wi3xi 431 5 show show VBP cord-016990-ot1wi3xi 431 6 multiple multiple JJ cord-016990-ot1wi3xi 431 7 , , , cord-016990-ot1wi3xi 431 8 scattered scatter VBN cord-016990-ot1wi3xi 431 9 , , , cord-016990-ot1wi3xi 431 10 defined define VBN cord-016990-ot1wi3xi 431 11 , , , cord-016990-ot1wi3xi 431 12 nodular nodular JJ cord-016990-ot1wi3xi 431 13 densities density NNS cord-016990-ot1wi3xi 431 14 . . . cord-016990-ot1wi3xi 432 1 Untreated untreated JJ cord-016990-ot1wi3xi 432 2 adult adult NN cord-016990-ot1wi3xi 432 3 varicella varicella NN cord-016990-ot1wi3xi 432 4 pneumonia pneumonia NN cord-016990-ot1wi3xi 432 5 is be VBZ cord-016990-ot1wi3xi 432 6 fatal fatal JJ cord-016990-ot1wi3xi 432 7 in in IN cord-016990-ot1wi3xi 432 8 approximately approximately RB cord-016990-ot1wi3xi 432 9 10 10 CD cord-016990-ot1wi3xi 432 10 % % NN cord-016990-ot1wi3xi 432 11 of of IN cord-016990-ot1wi3xi 432 12 cases case NNS cord-016990-ot1wi3xi 432 13 , , , cord-016990-ot1wi3xi 432 14 but but CC cord-016990-ot1wi3xi 432 15 mortality mortality NN cord-016990-ot1wi3xi 432 16 is be VBZ cord-016990-ot1wi3xi 432 17 as as RB cord-016990-ot1wi3xi 432 18 high high JJ cord-016990-ot1wi3xi 432 19 as as IN cord-016990-ot1wi3xi 432 20 25 25 CD cord-016990-ot1wi3xi 432 21 % % NN cord-016990-ot1wi3xi 432 22 to to IN cord-016990-ot1wi3xi 432 23 40 40 CD cord-016990-ot1wi3xi 432 24 % % NN cord-016990-ot1wi3xi 432 25 in in IN cord-016990-ot1wi3xi 432 26 certain certain JJ cord-016990-ot1wi3xi 432 27 high high JJ cord-016990-ot1wi3xi 432 28 - - HYPH cord-016990-ot1wi3xi 432 29 risk risk NN cord-016990-ot1wi3xi 432 30 cohorts cohort NNS cord-016990-ot1wi3xi 432 31 , , , cord-016990-ot1wi3xi 432 32 including include VBG cord-016990-ot1wi3xi 432 33 pregnant pregnant JJ cord-016990-ot1wi3xi 432 34 women woman NNS cord-016990-ot1wi3xi 432 35 , , , cord-016990-ot1wi3xi 432 36 transplant transplant NN cord-016990-ot1wi3xi 432 37 recipients recipient NNS cord-016990-ot1wi3xi 432 38 , , , cord-016990-ot1wi3xi 432 39 and and CC cord-016990-ot1wi3xi 432 40 neonates neonate NNS cord-016990-ot1wi3xi 432 41 . . . cord-016990-ot1wi3xi 433 1 137 137 CD cord-016990-ot1wi3xi 433 2 , , , cord-016990-ot1wi3xi 433 3 lfJ9 lfj9 NN cord-016990-ot1wi3xi 433 4 - - : cord-016990-ot1wi3xi 433 5 171 171 CD cord-016990-ot1wi3xi 433 6 Massive massive JJ cord-016990-ot1wi3xi 433 7 pulmonary pulmonary JJ cord-016990-ot1wi3xi 433 8 hemorrhage hemorrhage NN cord-016990-ot1wi3xi 433 9 is be VBZ cord-016990-ot1wi3xi 433 10 a a DT cord-016990-ot1wi3xi 433 11 frequent frequent JJ cord-016990-ot1wi3xi 433 12 terminal terminal NN cord-016990-ot1wi3xi 433 13 event event NN cord-016990-ot1wi3xi 433 14 . . . cord-016990-ot1wi3xi 434 1 Gross gross JJ cord-016990-ot1wi3xi 434 2 examination examination NN cord-016990-ot1wi3xi 434 3 reveals reveal VBZ cord-016990-ot1wi3xi 434 4 lungs lung NNS cord-016990-ot1wi3xi 434 5 that that WDT cord-016990-ot1wi3xi 434 6 are be VBP cord-016990-ot1wi3xi 434 7 generally generally RB cord-016990-ot1wi3xi 434 8 two two CD cord-016990-ot1wi3xi 434 9 to to TO cord-016990-ot1wi3xi 434 10 three three CD cord-016990-ot1wi3xi 434 11 times time NNS cord-016990-ot1wi3xi 434 12 heavier heavy JJR cord-016990-ot1wi3xi 434 13 than than IN cord-016990-ot1wi3xi 434 14 normal normal JJ cord-016990-ot1wi3xi 434 15 , , , cord-016990-ot1wi3xi 434 16 firm firm JJ cord-016990-ot1wi3xi 434 17 , , , cord-016990-ot1wi3xi 434 18 and and CC cord-016990-ot1wi3xi 434 19 plumcolored plumcolore VBD cord-016990-ot1wi3xi 434 20 . . . cord-016990-ot1wi3xi 435 1 There there EX cord-016990-ot1wi3xi 435 2 are be VBP cord-016990-ot1wi3xi 435 3 often often RB cord-016990-ot1wi3xi 435 4 multiple multiple JJ cord-016990-ot1wi3xi 435 5 necrotic necrotic JJ cord-016990-ot1wi3xi 435 6 and and CC cord-016990-ot1wi3xi 435 7 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 435 8 lesions lesion NNS cord-016990-ot1wi3xi 435 9 on on IN cord-016990-ot1wi3xi 435 10 the the DT cord-016990-ot1wi3xi 435 11 visceral visceral JJ cord-016990-ot1wi3xi 435 12 pleura pleura NN cord-016990-ot1wi3xi 435 13 that that WDT cord-016990-ot1wi3xi 435 14 resemble resemble VBP cord-016990-ot1wi3xi 435 15 the the DT cord-016990-ot1wi3xi 435 16 pox pox NN cord-016990-ot1wi3xi 435 17 lesions lesion NNS cord-016990-ot1wi3xi 435 18 of of IN cord-016990-ot1wi3xi 435 19 skin skin NN cord-016990-ot1wi3xi 435 20 . . . cord-016990-ot1wi3xi 436 1 169 169 CD cord-016990-ot1wi3xi 437 1 , , , cord-016990-ot1wi3xi 437 2 172,173 172,173 CD cord-016990-ot1wi3xi 437 3 Pox Pox NNP cord-016990-ot1wi3xi 437 4 may may MD cord-016990-ot1wi3xi 437 5 also also RB cord-016990-ot1wi3xi 437 6 be be VB cord-016990-ot1wi3xi 437 7 seen see VBN cord-016990-ot1wi3xi 437 8 on on IN cord-016990-ot1wi3xi 437 9 the the DT cord-016990-ot1wi3xi 437 10 parietal parietal JJ cord-016990-ot1wi3xi 437 11 pleura pleura NN cord-016990-ot1wi3xi 437 12 , , , cord-016990-ot1wi3xi 437 13 although although IN cord-016990-ot1wi3xi 437 14 pleural pleural JJ cord-016990-ot1wi3xi 437 15 effusions effusion NNS cord-016990-ot1wi3xi 437 16 are be VBP cord-016990-ot1wi3xi 437 17 uncommon uncommon JJ cord-016990-ot1wi3xi 437 18 and and CC cord-016990-ot1wi3xi 437 19 rarely rarely RB cord-016990-ot1wi3xi 437 20 prominent prominent JJ cord-016990-ot1wi3xi 437 21 . . . cord-016990-ot1wi3xi 438 1 163 163 CD cord-016990-ot1wi3xi 438 2 , , , cord-016990-ot1wi3xi 438 3 173 173 CD cord-016990-ot1wi3xi 439 1 The the DT cord-016990-ot1wi3xi 439 2 trachea trachea NN cord-016990-ot1wi3xi 439 3 and and CC cord-016990-ot1wi3xi 439 4 bronchi bronchi NN cord-016990-ot1wi3xi 439 5 are be VBP cord-016990-ot1wi3xi 439 6 generally generally RB cord-016990-ot1wi3xi 439 7 edematous edematous JJ cord-016990-ot1wi3xi 439 8 and and CC cord-016990-ot1wi3xi 439 9 erythematous erythematous JJ cord-016990-ot1wi3xi 439 10 with with IN cord-016990-ot1wi3xi 439 11 occasional occasional JJ cord-016990-ot1wi3xi 439 12 vesicles vesicle NNS cord-016990-ot1wi3xi 439 13 on on IN cord-016990-ot1wi3xi 439 14 the the DT cord-016990-ot1wi3xi 439 15 mucosal mucosal JJ cord-016990-ot1wi3xi 439 16 surfaces surface NNS cord-016990-ot1wi3xi 439 17 , , , cord-016990-ot1wi3xi 439 18 and and CC cord-016990-ot1wi3xi 439 19 there there EX cord-016990-ot1wi3xi 439 20 may may MD cord-016990-ot1wi3xi 439 21 be be VB cord-016990-ot1wi3xi 439 22 lobular lobular JJ cord-016990-ot1wi3xi 439 23 consolidation consolidation NN cord-016990-ot1wi3xi 439 24 of of IN cord-016990-ot1wi3xi 439 25 the the DT cord-016990-ot1wi3xi 439 26 lungs lung NNS cord-016990-ot1wi3xi 439 27 . . . cord-016990-ot1wi3xi 440 1 Microscopically microscopically RB cord-016990-ot1wi3xi 440 2 , , , cord-016990-ot1wi3xi 440 3 pulmonary pulmonary JJ cord-016990-ot1wi3xi 440 4 involvement involvement NN cord-016990-ot1wi3xi 440 5 consists consist VBZ cord-016990-ot1wi3xi 440 6 primarily primarily RB cord-016990-ot1wi3xi 440 7 of of IN cord-016990-ot1wi3xi 440 8 interstitial interstitial JJ cord-016990-ot1wi3xi 440 9 pneumonitis pneumonitis NN cord-016990-ot1wi3xi 440 10 and and CC cord-016990-ot1wi3xi 440 11 diffuse diffuse VB cord-016990-ot1wi3xi 440 12 miliary miliary JJ cord-016990-ot1wi3xi 440 13 foci foci NN cord-016990-ot1wi3xi 440 14 of of IN cord-016990-ot1wi3xi 440 15 necrosis necrosis NN cord-016990-ot1wi3xi 440 16 and and CC cord-016990-ot1wi3xi 440 17 hemorrhage hemorrhage NN cord-016990-ot1wi3xi 440 18 in in IN cord-016990-ot1wi3xi 440 19 the the DT cord-016990-ot1wi3xi 440 20 pulmonary pulmonary JJ cord-016990-ot1wi3xi 440 21 parenchyma parenchyma NNS cord-016990-ot1wi3xi 440 22 that that WDT cord-016990-ot1wi3xi 440 23 involve involve VBP cord-016990-ot1wi3xi 440 24 alveolar alveolar JJ cord-016990-ot1wi3xi 440 25 walls wall NNS cord-016990-ot1wi3xi 440 26 , , , cord-016990-ot1wi3xi 440 27 blood blood NN cord-016990-ot1wi3xi 440 28 vessels vessel NNS cord-016990-ot1wi3xi 440 29 , , , cord-016990-ot1wi3xi 440 30 and and CC cord-016990-ot1wi3xi 440 31 bronchioles bronchiole NNS cord-016990-ot1wi3xi 440 32 ( ( -LRB- cord-016990-ot1wi3xi 440 33 Fig Fig NNP cord-016990-ot1wi3xi 440 34 . . . cord-016990-ot1wi3xi 440 35 11.7B 11.7b CD cord-016990-ot1wi3xi 440 36 , , , cord-016990-ot1wi3xi 440 37 D D NNP cord-016990-ot1wi3xi 440 38 ) ) -RRB- cord-016990-ot1wi3xi 440 39 . . . cord-016990-ot1wi3xi 441 1 172 172 CD cord-016990-ot1wi3xi 441 2 Other other JJ cord-016990-ot1wi3xi 441 3 findings finding NNS cord-016990-ot1wi3xi 441 4 may may MD cord-016990-ot1wi3xi 441 5 include include VB cord-016990-ot1wi3xi 441 6 intraalveolar intraalveolar NN cord-016990-ot1wi3xi 441 7 collections collection NNS cord-016990-ot1wi3xi 441 8 of of IN cord-016990-ot1wi3xi 441 9 edema edema NN cord-016990-ot1wi3xi 441 10 , , , cord-016990-ot1wi3xi 441 11 fibrin fibrin NN cord-016990-ot1wi3xi 441 12 , , , cord-016990-ot1wi3xi 441 13 or or CC cord-016990-ot1wi3xi 441 14 hemorrhage hemorrhage NN cord-016990-ot1wi3xi 441 15 , , , cord-016990-ot1wi3xi 441 16 diffuse diffuse VB cord-016990-ot1wi3xi 441 17 alveolar alveolar JJ cord-016990-ot1wi3xi 441 18 damage damage NN cord-016990-ot1wi3xi 441 19 , , , cord-016990-ot1wi3xi 441 20 and and CC cord-016990-ot1wi3xi 441 21 septal septal JJ cord-016990-ot1wi3xi 441 22 edema edema NN cord-016990-ot1wi3xi 441 23 . . . cord-016990-ot1wi3xi 442 1 1 1 LS cord-016990-ot1wi3xi 442 2 M M NNP cord-016990-ot1wi3xi 442 3 , , , cord-016990-ot1wi3xi 442 4 168.173 168.173 CD cord-016990-ot1wi3xi 442 5 Virally Virally NNP cord-016990-ot1wi3xi 442 6 infected infect VBN cord-016990-ot1wi3xi 442 7 cells cell NNS cord-016990-ot1wi3xi 442 8 with with IN cord-016990-ot1wi3xi 442 9 intranuclear intranuclear NN cord-016990-ot1wi3xi 442 10 inclusions inclusion NNS cord-016990-ot1wi3xi 442 11 may may MD cord-016990-ot1wi3xi 442 12 be be VB cord-016990-ot1wi3xi 442 13 identified identify VBN cord-016990-ot1wi3xi 442 14 in in IN cord-016990-ot1wi3xi 442 15 respiratory respiratory JJ cord-016990-ot1wi3xi 442 16 epithelial epithelial JJ cord-016990-ot1wi3xi 442 17 cells cell NNS cord-016990-ot1wi3xi 442 18 , , , cord-016990-ot1wi3xi 442 19 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 442 20 , , , cord-016990-ot1wi3xi 442 21 interstitial interstitial JJ cord-016990-ot1wi3xi 442 22 fibroblasts fibroblast NNS cord-016990-ot1wi3xi 442 23 , , , cord-016990-ot1wi3xi 442 24 or or CC cord-016990-ot1wi3xi 442 25 capillary capillary JJ cord-016990-ot1wi3xi 442 26 endothelium endothelium NN cord-016990-ot1wi3xi 442 27 ( ( -LRB- cord-016990-ot1wi3xi 442 28 Fig fig NN cord-016990-ot1wi3xi 442 29 . . . cord-016990-ot1wi3xi 443 1 11 11 CD cord-016990-ot1wi3xi 443 2 .7E .7e UH cord-016990-ot1wi3xi 443 3 , , , cord-016990-ot1wi3xi 443 4 F).167 F).167 NNP cord-016990-ot1wi3xi 443 5 Eosinophilic eosinophilic JJ cord-016990-ot1wi3xi 443 6 intranuclear intranuclear NN cord-016990-ot1wi3xi 443 7 inclusions inclusion NNS cord-016990-ot1wi3xi 443 8 and and CC cord-016990-ot1wi3xi 443 9 multinucleated multinucleate VBN cord-016990-ot1wi3xi 443 10 syncytial syncytial JJ cord-016990-ot1wi3xi 443 11 cells cell NNS cord-016990-ot1wi3xi 443 12 may may MD cord-016990-ot1wi3xi 443 13 be be VB cord-016990-ot1wi3xi 443 14 difficult difficult JJ cord-016990-ot1wi3xi 443 15 to to TO cord-016990-ot1wi3xi 443 16 locate locate VB cord-016990-ot1wi3xi 443 17 but but CC cord-016990-ot1wi3xi 443 18 are be VBP cord-016990-ot1wi3xi 443 19 best well RBS cord-016990-ot1wi3xi 443 20 identified identify VBN cord-016990-ot1wi3xi 443 21 at at IN cord-016990-ot1wi3xi 443 22 the the DT cord-016990-ot1wi3xi 443 23 edges edge NNS cord-016990-ot1wi3xi 443 24 of of IN cord-016990-ot1wi3xi 443 25 necrotic necrotic JJ cord-016990-ot1wi3xi 443 26 foci focus NNS cord-016990-ot1wi3xi 443 27 ( ( -LRB- cord-016990-ot1wi3xi 443 28 Fig fig NN cord-016990-ot1wi3xi 443 29 . . . cord-016990-ot1wi3xi 443 30 11.7C 11.7c CD cord-016990-ot1wi3xi 443 31 ) ) -RRB- cord-016990-ot1wi3xi 443 32 . . . cord-016990-ot1wi3xi 444 1 In in IN cord-016990-ot1wi3xi 444 2 cases case NNS cord-016990-ot1wi3xi 444 3 of of IN cord-016990-ot1wi3xi 444 4 disseminated disseminate VBN cord-016990-ot1wi3xi 444 5 disease disease NN cord-016990-ot1wi3xi 444 6 , , , cord-016990-ot1wi3xi 444 7 similar similar JJ cord-016990-ot1wi3xi 444 8 necrotizing necrotize VBG cord-016990-ot1wi3xi 444 9 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 444 10 lesions lesion NNS cord-016990-ot1wi3xi 444 11 and and CC cord-016990-ot1wi3xi 444 12 occasional occasional JJ cord-016990-ot1wi3xi 444 13 viral viral JJ cord-016990-ot1wi3xi 444 14 cytopathic cytopathic JJ cord-016990-ot1wi3xi 444 15 changes change NNS cord-016990-ot1wi3xi 444 16 in in IN cord-016990-ot1wi3xi 444 17 epithelial epithelial JJ cord-016990-ot1wi3xi 444 18 cells cell NNS cord-016990-ot1wi3xi 444 19 or or CC cord-016990-ot1wi3xi 444 20 fibroblasts fibroblast NNS cord-016990-ot1wi3xi 444 21 may may MD cord-016990-ot1wi3xi 444 22 be be VB cord-016990-ot1wi3xi 444 23 observed observe VBN cord-016990-ot1wi3xi 444 24 in in IN cord-016990-ot1wi3xi 444 25 other other JJ cord-016990-ot1wi3xi 444 26 tissues tissue NNS cord-016990-ot1wi3xi 444 27 and and CC cord-016990-ot1wi3xi 444 28 organs organ NNS cord-016990-ot1wi3xi 444 29 , , , cord-016990-ot1wi3xi 444 30 including include VBG cord-016990-ot1wi3xi 444 31 esophagus esophagus NN cord-016990-ot1wi3xi 444 32 , , , cord-016990-ot1wi3xi 444 33 pancreas pancrea NNS cord-016990-ot1wi3xi 444 34 , , , cord-016990-ot1wi3xi 444 35 liver liver NN cord-016990-ot1wi3xi 444 36 , , , cord-016990-ot1wi3xi 444 37 renal renal JJ cord-016990-ot1wi3xi 444 38 pelves pelvis NNS cord-016990-ot1wi3xi 444 39 , , , cord-016990-ot1wi3xi 444 40 ureters ureter NNS cord-016990-ot1wi3xi 444 41 , , , cord-016990-ot1wi3xi 444 42 urinary urinary JJ cord-016990-ot1wi3xi 444 43 bladder bladder NN cord-016990-ot1wi3xi 444 44 , , , cord-016990-ot1wi3xi 444 45 spleen spleen NN cord-016990-ot1wi3xi 444 46 , , , cord-016990-ot1wi3xi 444 47 bone bone NN cord-016990-ot1wi3xi 444 48 marrow marrow NN cord-016990-ot1wi3xi 444 49 , , , cord-016990-ot1wi3xi 444 50 thymus thymus NN cord-016990-ot1wi3xi 444 51 , , , cord-016990-ot1wi3xi 444 52 lymph lymph NN cord-016990-ot1wi3xi 444 53 nodes node NNS cord-016990-ot1wi3xi 444 54 , , , cord-016990-ot1wi3xi 444 55 adrenal adrenal JJ cord-016990-ot1wi3xi 444 56 glands gland NNS cord-016990-ot1wi3xi 444 57 , , , cord-016990-ot1wi3xi 444 58 and and CC cord-016990-ot1wi3xi 444 59 brain brain NN cord-016990-ot1wi3xi 444 60 . . . cord-016990-ot1wi3xi 445 1 172,174 172,174 CD cord-016990-ot1wi3xi 446 1 In in IN cord-016990-ot1wi3xi 446 2 those those DT cord-016990-ot1wi3xi 446 3 patients patient NNS cord-016990-ot1wi3xi 446 4 who who WP cord-016990-ot1wi3xi 446 5 recover recover VBP cord-016990-ot1wi3xi 446 6 from from IN cord-016990-ot1wi3xi 446 7 severe severe JJ cord-016990-ot1wi3xi 446 8 VZV VZV NNP cord-016990-ot1wi3xi 446 9 pneumonia pneumonia NN cord-016990-ot1wi3xi 446 10 , , , cord-016990-ot1wi3xi 446 11 some some DT cord-016990-ot1wi3xi 446 12 necrotic necrotic JJ cord-016990-ot1wi3xi 446 13 parenchymal parenchymal NN cord-016990-ot1wi3xi 446 14 foci foci NN cord-016990-ot1wi3xi 446 15 may may MD cord-016990-ot1wi3xi 446 16 mineralize mineralize VB cord-016990-ot1wi3xi 446 17 , , , cord-016990-ot1wi3xi 446 18 and and CC cord-016990-ot1wi3xi 446 19 can can MD cord-016990-ot1wi3xi 446 20 be be VB cord-016990-ot1wi3xi 446 21 identified identify VBN cord-016990-ot1wi3xi 446 22 by by IN cord-016990-ot1wi3xi 446 23 chest chest NN cord-016990-ot1wi3xi 446 24 radiograph radiograph NN cord-016990-ot1wi3xi 446 25 years year NNS cord-016990-ot1wi3xi 446 26 later later RB cord-016990-ot1wi3xi 446 27 as as IN cord-016990-ot1wi3xi 446 28 miliary miliary JJ cord-016990-ot1wi3xi 446 29 , , , cord-016990-ot1wi3xi 446 30 1 1 CD cord-016990-ot1wi3xi 446 31 to to IN cord-016990-ot1wi3xi 446 32 5 5 CD cord-016990-ot1wi3xi 446 33 mm mm NN cord-016990-ot1wi3xi 446 34 , , , cord-016990-ot1wi3xi 446 35 nodular nodular JJ cord-016990-ot1wi3xi 446 36 opacities opacity NNS cord-016990-ot1wi3xi 446 37 . . . cord-016990-ot1wi3xi 447 1 Microscopically microscopically RB cord-016990-ot1wi3xi 447 2 , , , cord-016990-ot1wi3xi 447 3 the the DT cord-016990-ot1wi3xi 447 4 lesions lesion NNS cord-016990-ot1wi3xi 447 5 are be VBP cord-016990-ot1wi3xi 447 6 characterized characterize VBN cord-016990-ot1wi3xi 447 7 as as IN cord-016990-ot1wi3xi 447 8 discrete discrete JJ cord-016990-ot1wi3xi 447 9 collections collection NNS cord-016990-ot1wi3xi 447 10 of of IN cord-016990-ot1wi3xi 447 11 dense dense JJ cord-016990-ot1wi3xi 447 12 fibrous fibrous JJ cord-016990-ot1wi3xi 447 13 connective connective JJ cord-016990-ot1wi3xi 447 14 tissue tissue NN cord-016990-ot1wi3xi 447 15 that that WDT cord-016990-ot1wi3xi 447 16 surround surround VBP cord-016990-ot1wi3xi 447 17 multiple multiple JJ cord-016990-ot1wi3xi 447 18 , , , cord-016990-ot1wi3xi 447 19 small small JJ cord-016990-ot1wi3xi 447 20 , , , cord-016990-ot1wi3xi 447 21 calcified calcified JJ cord-016990-ot1wi3xi 447 22 bodies body NNS cord-016990-ot1wi3xi 447 23 . . . cord-016990-ot1wi3xi 448 1 The the DT cord-016990-ot1wi3xi 448 2 periphery periphery NN cord-016990-ot1wi3xi 448 3 may may MD cord-016990-ot1wi3xi 448 4 include include VB cord-016990-ot1wi3xi 448 5 a a DT cord-016990-ot1wi3xi 448 6 cellular cellular JJ cord-016990-ot1wi3xi 448 7 zone zone NN cord-016990-ot1wi3xi 448 8 of of IN cord-016990-ot1wi3xi 448 9 fibroblasts fibroblast NNS cord-016990-ot1wi3xi 448 10 and and CC cord-016990-ot1wi3xi 448 11 occasional occasional JJ cord-016990-ot1wi3xi 448 12 giant giant NN cord-016990-ot1wi3xi 449 1 cells.175 cells.175 NNP cord-016990-ot1wi3xi 449 2 A a DT cord-016990-ot1wi3xi 449 3 radiographic radiographic JJ cord-016990-ot1wi3xi 449 4 survey survey NN cord-016990-ot1wi3xi 449 5 of of IN cord-016990-ot1wi3xi 449 6 16,894 16,894 CD cord-016990-ot1wi3xi 449 7 persons person NNS cord-016990-ot1wi3xi 449 8 identified identify VBD cord-016990-ot1wi3xi 449 9 pulmonary pulmonary JJ cord-016990-ot1wi3xi 449 10 calcifications calcification NNS cord-016990-ot1wi3xi 449 11 in in IN cord-016990-ot1wi3xi 449 12 eight eight CD cord-016990-ot1wi3xi 449 13 ( ( -LRB- cord-016990-ot1wi3xi 449 14 1.7 1.7 CD cord-016990-ot1wi3xi 449 15 % % NN cord-016990-ot1wi3xi 449 16 ) ) -RRB- cord-016990-ot1wi3xi 449 17 of of IN cord-016990-ot1wi3xi 449 18 463 463 CD cord-016990-ot1wi3xi 449 19 patients patient NNS cord-016990-ot1wi3xi 449 20 who who WP cord-016990-ot1wi3xi 449 21 had have VBD cord-016990-ot1wi3xi 449 22 chickenpox chickenpox NN cord-016990-ot1wi3xi 449 23 during during IN cord-016990-ot1wi3xi 449 24 adulthood adulthood NN cord-016990-ot1wi3xi 449 25 compared compare VBN cord-016990-ot1wi3xi 449 26 with with IN cord-016990-ot1wi3xi 449 27 only only RB cord-016990-ot1wi3xi 449 28 eight eight CD cord-016990-ot1wi3xi 449 29 ( ( -LRB- cord-016990-ot1wi3xi 449 30 0.05 0.05 CD cord-016990-ot1wi3xi 449 31 % % NN cord-016990-ot1wi3xi 449 32 ) ) -RRB- cord-016990-ot1wi3xi 449 33 of of IN cord-016990-ot1wi3xi 449 34 the the DT cord-016990-ot1wi3xi 449 35 remaining remain VBG cord-016990-ot1wi3xi 449 36 16,431 16,431 CD cord-016990-ot1wi3xi 449 37 who who WP cord-016990-ot1wi3xi 449 38 did do VBD cord-016990-ot1wi3xi 449 39 not not RB cord-016990-ot1wi3xi 449 40 report report VB cord-016990-ot1wi3xi 449 41 having have VBG cord-016990-ot1wi3xi 449 42 varicella varicella NN cord-016990-ot1wi3xi 449 43 as as IN cord-016990-ot1wi3xi 449 44 an an DT cord-016990-ot1wi3xi 449 45 adult adult NN cord-016990-ot1wi3xi 449 46 . . . cord-016990-ot1wi3xi 450 1 176 176 CD cord-016990-ot1wi3xi 451 1 A a DT cord-016990-ot1wi3xi 451 2 positive positive JJ cord-016990-ot1wi3xi 451 3 history history NN cord-016990-ot1wi3xi 451 4 of of IN cord-016990-ot1wi3xi 451 5 varicella varicella NN cord-016990-ot1wi3xi 451 6 predicts predict VBZ cord-016990-ot1wi3xi 451 7 immunity immunity NN cord-016990-ot1wi3xi 451 8 in in IN cord-016990-ot1wi3xi 451 9 > > $ cord-016990-ot1wi3xi 451 10 95 95 CD cord-016990-ot1wi3xi 451 11 % % NN cord-016990-ot1wi3xi 451 12 of of IN cord-016990-ot1wi3xi 451 13 persons person NNS cord-016990-ot1wi3xi 451 14 . . . cord-016990-ot1wi3xi 452 1 160 160 CD cord-016990-ot1wi3xi 453 1 Because because IN cord-016990-ot1wi3xi 453 2 pulmonary pulmonary JJ cord-016990-ot1wi3xi 453 3 symptoms symptom NNS cord-016990-ot1wi3xi 453 4 most most RBS cord-016990-ot1wi3xi 453 5 often often RB cord-016990-ot1wi3xi 453 6 occur occur VBP cord-016990-ot1wi3xi 453 7 several several JJ cord-016990-ot1wi3xi 453 8 days day NNS cord-016990-ot1wi3xi 453 9 following follow VBG cord-016990-ot1wi3xi 453 10 the the DT cord-016990-ot1wi3xi 453 11 onset onset NN cord-016990-ot1wi3xi 453 12 of of IN cord-016990-ot1wi3xi 453 13 the the DT cord-016990-ot1wi3xi 453 14 characteristic characteristic JJ cord-016990-ot1wi3xi 453 15 rash rash NN cord-016990-ot1wi3xi 453 16 of of IN cord-016990-ot1wi3xi 453 17 varicella varicella NN cord-016990-ot1wi3xi 453 18 , , , cord-016990-ot1wi3xi 453 19 a a DT cord-016990-ot1wi3xi 453 20 pathologic pathologic JJ cord-016990-ot1wi3xi 453 21 diagnosis diagnosis NN cord-016990-ot1wi3xi 453 22 is be VBZ cord-016990-ot1wi3xi 453 23 seldom seldom RB cord-016990-ot1wi3xi 453 24 required require VBN cord-016990-ot1wi3xi 453 25 for for IN cord-016990-ot1wi3xi 453 26 a a DT cord-016990-ot1wi3xi 453 27 real real JJ cord-016990-ot1wi3xi 453 28 - - HYPH cord-016990-ot1wi3xi 453 29 time time NN cord-016990-ot1wi3xi 453 30 diagnosis diagnosis NN cord-016990-ot1wi3xi 453 31 of of IN cord-016990-ot1wi3xi 453 32 VZV VZV NNP cord-016990-ot1wi3xi 453 33 pneumonia pneumonia NN cord-016990-ot1wi3xi 453 34 . . . cord-016990-ot1wi3xi 454 1 However however RB cord-016990-ot1wi3xi 454 2 , , , cord-016990-ot1wi3xi 454 3 hematopoietic hematopoietic JJ cord-016990-ot1wi3xi 454 4 cell cell NN cord-016990-ot1wi3xi 454 5 transplant transplant NN cord-016990-ot1wi3xi 454 6 recipients recipient NNS cord-016990-ot1wi3xi 454 7 may may MD cord-016990-ot1wi3xi 454 8 present present VB cord-016990-ot1wi3xi 454 9 with with IN cord-016990-ot1wi3xi 454 10 signs sign NNS cord-016990-ot1wi3xi 454 11 of of IN cord-016990-ot1wi3xi 454 12 visceral visceral JJ cord-016990-ot1wi3xi 454 13 dissemination dissemination NN cord-016990-ot1wi3xi 454 14 and and CC cord-016990-ot1wi3xi 454 15 pneumonia pneumonia NN cord-016990-ot1wi3xi 454 16 1 1 CD cord-016990-ot1wi3xi 454 17 to to IN cord-016990-ot1wi3xi 454 18 4 4 CD cord-016990-ot1wi3xi 454 19 days day NNS cord-016990-ot1wi3xi 454 20 before before IN cord-016990-ot1wi3xi 454 21 the the DT cord-016990-ot1wi3xi 454 22 localized localize VBN cord-016990-ot1wi3xi 454 23 cutaneous cutaneous JJ cord-016990-ot1wi3xi 454 24 eruption eruption NN cord-016990-ot1wi3xi 454 25 of of IN cord-016990-ot1wi3xi 454 26 herpes herpes NNP cord-016990-ot1wi3xi 454 27 zoster zoster NNP cord-016990-ot1wi3xi 454 28 appears appear VBZ cord-016990-ot1wi3xi 454 29 , , , cord-016990-ot1wi3xi 454 30 and and CC cord-016990-ot1wi3xi 454 31 lower low JJR cord-016990-ot1wi3xi 454 32 respiratory respiratory JJ cord-016990-ot1wi3xi 454 33 tract tract NN cord-016990-ot1wi3xi 454 34 disease disease NN cord-016990-ot1wi3xi 454 35 has have VBZ cord-016990-ot1wi3xi 454 36 been be VBN cord-016990-ot1wi3xi 454 37 described describe VBN cord-016990-ot1wi3xi 454 38 in in IN cord-016990-ot1wi3xi 454 39 the the DT cord-016990-ot1wi3xi 454 40 absence absence NN cord-016990-ot1wi3xi 454 41 of of IN cord-016990-ot1wi3xi 454 42 skin skin NN cord-016990-ot1wi3xi 454 43 lesions lesion NNS cord-016990-ot1wi3xi 454 44 , , , cord-016990-ot1wi3xi 454 45 particularly particularly RB cord-016990-ot1wi3xi 454 46 in in IN cord-016990-ot1wi3xi 454 47 neonates neonate NNS cord-016990-ot1wi3xi 454 48 and and CC cord-016990-ot1wi3xi 454 49 bone bone NN cord-016990-ot1wi3xi 454 50 marrow marrow NN cord-016990-ot1wi3xi 454 51 transplant transplant NN cord-016990-ot1wi3xi 454 52 recipients recipient NNS cord-016990-ot1wi3xi 454 53 . . . cord-016990-ot1wi3xi 455 1 26 26 CD cord-016990-ot1wi3xi 455 2 , , , cord-016990-ot1wi3xi 455 3 137,177 137,177 CD cord-016990-ot1wi3xi 455 4 Commercially commercially RB cord-016990-ot1wi3xi 455 5 available available JJ cord-016990-ot1wi3xi 455 6 antigen antigen NN cord-016990-ot1wi3xi 455 7 detection detection NN cord-016990-ot1wi3xi 455 8 kits kit NNS cord-016990-ot1wi3xi 455 9 can can MD cord-016990-ot1wi3xi 455 10 be be VB cord-016990-ot1wi3xi 455 11 used use VBN cord-016990-ot1wi3xi 455 12 for for IN cord-016990-ot1wi3xi 455 13 rapid rapid JJ cord-016990-ot1wi3xi 455 14 diagnosis diagnosis NN cord-016990-ot1wi3xi 455 15 of of IN cord-016990-ot1wi3xi 455 16 cutaneous cutaneous JJ cord-016990-ot1wi3xi 455 17 VZV VZV NNP cord-016990-ot1wi3xi 455 18 infection infection NN cord-016990-ot1wi3xi 455 19 . . . cord-016990-ot1wi3xi 456 1 Epithelial epithelial JJ cord-016990-ot1wi3xi 456 2 cells cell NNS cord-016990-ot1wi3xi 456 3 are be VBP cord-016990-ot1wi3xi 456 4 scraped scrape VBN cord-016990-ot1wi3xi 456 5 from from IN cord-016990-ot1wi3xi 456 6 the the DT cord-016990-ot1wi3xi 456 7 base base NN cord-016990-ot1wi3xi 456 8 of of IN cord-016990-ot1wi3xi 456 9 a a DT cord-016990-ot1wi3xi 456 10 newly newly RB cord-016990-ot1wi3xi 456 11 formed form VBN cord-016990-ot1wi3xi 456 12 vesicle vesicle NN cord-016990-ot1wi3xi 456 13 , , , cord-016990-ot1wi3xi 456 14 applied apply VBD cord-016990-ot1wi3xi 456 15 to to IN cord-016990-ot1wi3xi 456 16 a a DT cord-016990-ot1wi3xi 456 17 slide slide NN cord-016990-ot1wi3xi 456 18 , , , cord-016990-ot1wi3xi 456 19 and and CC cord-016990-ot1wi3xi 456 20 stained stain VBN cord-016990-ot1wi3xi 456 21 by by IN cord-016990-ot1wi3xi 456 22 using use VBG cord-016990-ot1wi3xi 456 23 fluorescein fluorescein NN cord-016990-ot1wi3xi 456 24 - - HYPH cord-016990-ot1wi3xi 456 25 conjugated conjugate VBN cord-016990-ot1wi3xi 456 26 VZV VZV NNP cord-016990-ot1wi3xi 456 27 monoclonal monoclonal JJ cord-016990-ot1wi3xi 456 28 antibodies antibody NNS cord-016990-ot1wi3xi 456 29 to to TO cord-016990-ot1wi3xi 456 30 detect detect VB cord-016990-ot1wi3xi 456 31 specific specific JJ cord-016990-ot1wi3xi 456 32 viral viral JJ cord-016990-ot1wi3xi 456 33 proteins protein NNS cord-016990-ot1wi3xi 456 34 in in IN cord-016990-ot1wi3xi 456 35 the the DT cord-016990-ot1wi3xi 456 36 specimen specimen NN cord-016990-ot1wi3xi 456 37 . . . cord-016990-ot1wi3xi 457 1 In in IN cord-016990-ot1wi3xi 457 2 a a DT cord-016990-ot1wi3xi 457 3 similar similar JJ cord-016990-ot1wi3xi 457 4 manner manner NN cord-016990-ot1wi3xi 457 5 , , , cord-016990-ot1wi3xi 457 6 the the DT cord-016990-ot1wi3xi 457 7 Tzanck Tzanck NNP cord-016990-ot1wi3xi 457 8 test test NN cord-016990-ot1wi3xi 457 9 uses use VBZ cord-016990-ot1wi3xi 457 10 Wright Wright NNP cord-016990-ot1wi3xi 457 11 - - HYPH cord-016990-ot1wi3xi 457 12 Giemsa Giemsa NNP cord-016990-ot1wi3xi 457 13 stain stain NN cord-016990-ot1wi3xi 457 14 to to TO cord-016990-ot1wi3xi 457 15 demonstrate demonstrate VB cord-016990-ot1wi3xi 457 16 multinucleated multinucleated JJ cord-016990-ot1wi3xi 457 17 giant giant JJ cord-016990-ot1wi3xi 457 18 cells cell NNS cord-016990-ot1wi3xi 457 19 in in IN cord-016990-ot1wi3xi 457 20 these these DT cord-016990-ot1wi3xi 457 21 specimens specimen NNS cord-016990-ot1wi3xi 457 22 ; ; : cord-016990-ot1wi3xi 457 23 however however RB cord-016990-ot1wi3xi 457 24 , , , cord-016990-ot1wi3xi 457 25 this this DT cord-016990-ot1wi3xi 457 26 test test NN cord-016990-ot1wi3xi 457 27 does do VBZ cord-016990-ot1wi3xi 457 28 not not RB cord-016990-ot1wi3xi 457 29 differentiate differentiate VB cord-016990-ot1wi3xi 457 30 between between IN cord-016990-ot1wi3xi 457 31 HSV HSV NNP cord-016990-ot1wi3xi 457 32 and and CC cord-016990-ot1wi3xi 457 33 VZV VZV NNP cord-016990-ot1wi3xi 457 34 , , , cord-016990-ot1wi3xi 457 35 and and CC cord-016990-ot1wi3xi 457 36 false false JJ cord-016990-ot1wi3xi 457 37 - - HYPH cord-016990-ot1wi3xi 457 38 negative negative JJ cord-016990-ot1wi3xi 457 39 results result NNS cord-016990-ot1wi3xi 457 40 are be VBP cord-016990-ot1wi3xi 457 41 common common JJ cord-016990-ot1wi3xi 457 42 . . . cord-016990-ot1wi3xi 458 1 Commercially commercially RB cord-016990-ot1wi3xi 458 2 available available JJ cord-016990-ot1wi3xi 458 3 antibodies antibody NNS cord-016990-ot1wi3xi 458 4 are be VBP cord-016990-ot1wi3xi 458 5 also also RB cord-016990-ot1wi3xi 458 6 available available JJ cord-016990-ot1wi3xi 458 7 for for IN cord-016990-ot1wi3xi 458 8 IHC IHC NNP cord-016990-ot1wi3xi 458 9 detection detection NN cord-016990-ot1wi3xi 458 10 of of IN cord-016990-ot1wi3xi 458 11 VZV VZV NNP cord-016990-ot1wi3xi 458 12 in in IN cord-016990-ot1wi3xi 458 13 tissue tissue NN cord-016990-ot1wi3xi 458 14 specimens specimen NNS cord-016990-ot1wi3xi 458 15 ( ( -LRB- cord-016990-ot1wi3xi 459 1 Fig fig NN cord-016990-ot1wi3xi 459 2 . . . cord-016990-ot1wi3xi 459 3 11 11 CD cord-016990-ot1wi3xi 459 4 .7E .7e XX cord-016990-ot1wi3xi 459 5 , , , cord-016990-ot1wi3xi 459 6 F F NNP cord-016990-ot1wi3xi 459 7 ) ) -RRB- cord-016990-ot1wi3xi 459 8 ; ; : cord-016990-ot1wi3xi 459 9 however however RB cord-016990-ot1wi3xi 459 10 , , , cord-016990-ot1wi3xi 459 11 relatively relatively RB cord-016990-ot1wi3xi 459 12 few few JJ cord-016990-ot1wi3xi 459 13 laboratories laboratory NNS cord-016990-ot1wi3xi 459 14 are be VBP cord-016990-ot1wi3xi 459 15 able able JJ cord-016990-ot1wi3xi 459 16 to to TO cord-016990-ot1wi3xi 459 17 provide provide VB cord-016990-ot1wi3xi 459 18 well well RB cord-016990-ot1wi3xi 459 19 - - HYPH cord-016990-ot1wi3xi 459 20 validated validate VBN cord-016990-ot1wi3xi 459 21 assays assay NNS cord-016990-ot1wi3xi 459 22 . . . cord-016990-ot1wi3xi 460 1 Some some DT cord-016990-ot1wi3xi 460 2 commercial commercial JJ cord-016990-ot1wi3xi 460 3 laboratories laboratory NNS cord-016990-ot1wi3xi 460 4 offer offer VBP cord-016990-ot1wi3xi 460 5 PCR PCR NNP cord-016990-ot1wi3xi 460 6 amplification amplification NN cord-016990-ot1wi3xi 460 7 to to TO cord-016990-ot1wi3xi 460 8 detect detect VB cord-016990-ot1wi3xi 460 9 viral viral JJ cord-016990-ot1wi3xi 460 10 nucleic nucleic JJ cord-016990-ot1wi3xi 460 11 acid acid NN cord-016990-ot1wi3xi 460 12 in in IN cord-016990-ot1wi3xi 460 13 clinical clinical JJ cord-016990-ot1wi3xi 460 14 specimens specimen NNS cord-016990-ot1wi3xi 460 15 . . . cord-016990-ot1wi3xi 461 1 Isolation isolation NN cord-016990-ot1wi3xi 461 2 of of IN cord-016990-ot1wi3xi 461 3 the the DT cord-016990-ot1wi3xi 461 4 virus virus NN cord-016990-ot1wi3xi 461 5 in in IN cord-016990-ot1wi3xi 461 6 cell cell NN cord-016990-ot1wi3xi 461 7 culture culture NN cord-016990-ot1wi3xi 461 8 remains remain VBZ cord-016990-ot1wi3xi 461 9 the the DT cord-016990-ot1wi3xi 461 10 reference reference NN cord-016990-ot1wi3xi 461 11 standard standard NN cord-016990-ot1wi3xi 461 12 for for IN cord-016990-ot1wi3xi 461 13 the the DT cord-016990-ot1wi3xi 461 14 diagnosis diagnosis NN cord-016990-ot1wi3xi 461 15 of of IN cord-016990-ot1wi3xi 461 16 VZv VZv NNS cord-016990-ot1wi3xi 461 17 . . . cord-016990-ot1wi3xi 462 1 In in IN cord-016990-ot1wi3xi 462 2 human human JJ cord-016990-ot1wi3xi 462 3 melanoma melanoma NN cord-016990-ot1wi3xi 462 4 cells cell NNS cord-016990-ot1wi3xi 462 5 , , , cord-016990-ot1wi3xi 462 6 an an DT cord-016990-ot1wi3xi 462 7 excellent excellent JJ cord-016990-ot1wi3xi 462 8 substrate substrate NN cord-016990-ot1wi3xi 462 9 for for IN cord-016990-ot1wi3xi 462 10 VZV VZV NNP cord-016990-ot1wi3xi 462 11 isolation isolation NN cord-016990-ot1wi3xi 462 12 , , , cord-016990-ot1wi3xi 462 13 the the DT cord-016990-ot1wi3xi 462 14 average average JJ cord-016990-ot1wi3xi 462 15 time time NN cord-016990-ot1wi3xi 462 16 for for IN cord-016990-ot1wi3xi 462 17 visible visible JJ cord-016990-ot1wi3xi 462 18 cytopathic cytopathic JJ cord-016990-ot1wi3xi 462 19 effect effect NN cord-016990-ot1wi3xi 462 20 from from IN cord-016990-ot1wi3xi 462 21 the the DT cord-016990-ot1wi3xi 462 22 virus virus NN cord-016990-ot1wi3xi 462 23 is be VBZ cord-016990-ot1wi3xi 462 24 3 3 CD cord-016990-ot1wi3xi 462 25 to to TO cord-016990-ot1wi3xi 462 26 5 5 CD cord-016990-ot1wi3xi 462 27 days.178 days.178 JJ cord-016990-ot1wi3xi 462 28 Infectious infectious JJ cord-016990-ot1wi3xi 462 29 VZV VZV NNP cord-016990-ot1wi3xi 462 30 is be VBZ cord-016990-ot1wi3xi 462 31 usually usually RB cord-016990-ot1wi3xi 462 32 recoverable recoverable JJ cord-016990-ot1wi3xi 462 33 from from IN cord-016990-ot1wi3xi 462 34 the the DT cord-016990-ot1wi3xi 462 35 clear clear JJ cord-016990-ot1wi3xi 462 36 fluid fluid NN cord-016990-ot1wi3xi 462 37 of of IN cord-016990-ot1wi3xi 462 38 cutaneous cutaneous JJ cord-016990-ot1wi3xi 462 39 vesicles vesicle NNS cord-016990-ot1wi3xi 462 40 of of IN cord-016990-ot1wi3xi 462 41 varicella varicella NN cord-016990-ot1wi3xi 462 42 for for IN cord-016990-ot1wi3xi 462 43 approximately approximately RB cord-016990-ot1wi3xi 462 44 3 3 CD cord-016990-ot1wi3xi 462 45 days day NNS cord-016990-ot1wi3xi 462 46 after after IN cord-016990-ot1wi3xi 462 47 the the DT cord-016990-ot1wi3xi 462 48 appearance appearance NN cord-016990-ot1wi3xi 462 49 of of IN cord-016990-ot1wi3xi 462 50 these these DT cord-016990-ot1wi3xi 462 51 lesions lesion NNS cord-016990-ot1wi3xi 462 52 and and CC cord-016990-ot1wi3xi 462 53 for for IN cord-016990-ot1wi3xi 462 54 approximately approximately RB cord-016990-ot1wi3xi 462 55 1 1 CD cord-016990-ot1wi3xi 462 56 week week NN cord-016990-ot1wi3xi 462 57 from from IN cord-016990-ot1wi3xi 462 58 herpes herpes NNP cord-016990-ot1wi3xi 462 59 zoster zoster NN cord-016990-ot1wi3xi 462 60 lesions lesion NNS cord-016990-ot1wi3xi 462 61 . . . cord-016990-ot1wi3xi 463 1 The the DT cord-016990-ot1wi3xi 463 2 lungs lung NNS cord-016990-ot1wi3xi 463 3 are be VBP cord-016990-ot1wi3xi 463 4 the the DT cord-016990-ot1wi3xi 463 5 most most RBS cord-016990-ot1wi3xi 463 6 common common JJ cord-016990-ot1wi3xi 463 7 organ organ NN cord-016990-ot1wi3xi 463 8 from from IN cord-016990-ot1wi3xi 463 9 which which WDT cord-016990-ot1wi3xi 463 10 VZV VZV NNP cord-016990-ot1wi3xi 463 11 is be VBZ cord-016990-ot1wi3xi 463 12 isolated isolate VBN cord-016990-ot1wi3xi 463 13 at at IN cord-016990-ot1wi3xi 463 14 autopsy autopsy NN cord-016990-ot1wi3xi 463 15 , , , cord-016990-ot1wi3xi 463 16 but but CC cord-016990-ot1wi3xi 463 17 isolates isolate NNS cord-016990-ot1wi3xi 463 18 have have VBP cord-016990-ot1wi3xi 463 19 also also RB cord-016990-ot1wi3xi 463 20 been be VBN cord-016990-ot1wi3xi 463 21 obtained obtain VBN cord-016990-ot1wi3xi 463 22 from from IN cord-016990-ot1wi3xi 463 23 heart heart NN cord-016990-ot1wi3xi 463 24 , , , cord-016990-ot1wi3xi 463 25 liver liver NN cord-016990-ot1wi3xi 463 26 , , , cord-016990-ot1wi3xi 463 27 pancreas pancrea NNS cord-016990-ot1wi3xi 463 28 , , , cord-016990-ot1wi3xi 463 29 gastrointestinal gastrointestinal JJ cord-016990-ot1wi3xi 463 30 tract tract NN cord-016990-ot1wi3xi 463 31 , , , cord-016990-ot1wi3xi 463 32 brain brain NN cord-016990-ot1wi3xi 463 33 , , , cord-016990-ot1wi3xi 463 34 and and CC cord-016990-ot1wi3xi 463 35 eyes eye NNS cord-016990-ot1wi3xi 463 36 . . . cord-016990-ot1wi3xi 464 1 160 160 CD cord-016990-ot1wi3xi 464 2 _SP cord-016990-ot1wi3xi 465 1 Influenza influenza NN cord-016990-ot1wi3xi 465 2 is be VBZ cord-016990-ot1wi3xi 465 3 derived derive VBN cord-016990-ot1wi3xi 465 4 from from IN cord-016990-ot1wi3xi 465 5 the the DT cord-016990-ot1wi3xi 465 6 term term NN cord-016990-ot1wi3xi 465 7 influentia influentia NN cord-016990-ot1wi3xi 465 8 , , , cord-016990-ot1wi3xi 465 9 meaning mean VBG cord-016990-ot1wi3xi 465 10 epidemic epidemic NN cord-016990-ot1wi3xi 465 11 in in IN cord-016990-ot1wi3xi 465 12 the the DT cord-016990-ot1wi3xi 465 13 Italian italian JJ cord-016990-ot1wi3xi 465 14 form form NN cord-016990-ot1wi3xi 465 15 of of IN cord-016990-ot1wi3xi 465 16 Latin Latin NNP cord-016990-ot1wi3xi 465 17 , , , cord-016990-ot1wi3xi 465 18 originally originally RB cord-016990-ot1wi3xi 465 19 used use VBN cord-016990-ot1wi3xi 465 20 because because IN cord-016990-ot1wi3xi 465 21 epidemics epidemic NNS cord-016990-ot1wi3xi 465 22 were be VBD cord-016990-ot1wi3xi 465 23 thought think VBN cord-016990-ot1wi3xi 465 24 to to TO cord-016990-ot1wi3xi 465 25 result result VB cord-016990-ot1wi3xi 465 26 from from IN cord-016990-ot1wi3xi 465 27 astrologic astrologic JJ cord-016990-ot1wi3xi 465 28 or or CC cord-016990-ot1wi3xi 465 29 other other JJ cord-016990-ot1wi3xi 465 30 occult occult JJ cord-016990-ot1wi3xi 465 31 influences influence NNS cord-016990-ot1wi3xi 465 32 . . . cord-016990-ot1wi3xi 466 1 Influenza influenza NN cord-016990-ot1wi3xi 466 2 is be VBZ cord-016990-ot1wi3xi 466 3 a a DT cord-016990-ot1wi3xi 466 4 highly highly RB cord-016990-ot1wi3xi 466 5 contagious contagious JJ cord-016990-ot1wi3xi 466 6 , , , cord-016990-ot1wi3xi 466 7 acute acute JJ cord-016990-ot1wi3xi 466 8 respiratory respiratory JJ cord-016990-ot1wi3xi 466 9 illness illness NN cord-016990-ot1wi3xi 466 10 with with IN cord-016990-ot1wi3xi 466 11 a a DT cord-016990-ot1wi3xi 466 12 spectrum spectrum NN cord-016990-ot1wi3xi 466 13 of of IN cord-016990-ot1wi3xi 466 14 clinical clinical JJ cord-016990-ot1wi3xi 466 15 illness illness NN cord-016990-ot1wi3xi 466 16 ranging range VBG cord-016990-ot1wi3xi 466 17 from from IN cord-016990-ot1wi3xi 466 18 asymptomatic asymptomatic JJ cord-016990-ot1wi3xi 466 19 or or CC cord-016990-ot1wi3xi 466 20 mild mild JJ cord-016990-ot1wi3xi 466 21 disease disease NN cord-016990-ot1wi3xi 466 22 with with IN cord-016990-ot1wi3xi 466 23 rhinitis rhinitis NN cord-016990-ot1wi3xi 466 24 or or CC cord-016990-ot1wi3xi 466 25 pharyngitis pharyngitis NN cord-016990-ot1wi3xi 466 26 to to IN cord-016990-ot1wi3xi 466 27 primary primary JJ cord-016990-ot1wi3xi 466 28 viral viral JJ cord-016990-ot1wi3xi 466 29 pneumonia pneumonia NN cord-016990-ot1wi3xi 466 30 with with IN cord-016990-ot1wi3xi 466 31 S.R. S.R. NNP cord-016990-ot1wi3xi 466 32 Zaki Zaki NNP cord-016990-ot1wi3xi 466 33 and and CC cord-016990-ot1wi3xi 466 34 CD CD NNP cord-016990-ot1wi3xi 466 35 . . . cord-016990-ot1wi3xi 467 1 Paddock paddock NN cord-016990-ot1wi3xi 467 2 fatal fatal JJ cord-016990-ot1wi3xi 467 3 outcome outcome NN cord-016990-ot1wi3xi 467 4 . . . cord-016990-ot1wi3xi 468 1 Influenza Influenza NNP cord-016990-ot1wi3xi 468 2 may may MD cord-016990-ot1wi3xi 468 3 also also RB cord-016990-ot1wi3xi 468 4 be be VB cord-016990-ot1wi3xi 468 5 associated associate VBN cord-016990-ot1wi3xi 468 6 with with IN cord-016990-ot1wi3xi 468 7 a a DT cord-016990-ot1wi3xi 468 8 broad broad JJ cord-016990-ot1wi3xi 468 9 range range NN cord-016990-ot1wi3xi 468 10 of of IN cord-016990-ot1wi3xi 468 11 other other JJ cord-016990-ot1wi3xi 468 12 disorders disorder NNS cord-016990-ot1wi3xi 468 13 affecting affect VBG cord-016990-ot1wi3xi 468 14 the the DT cord-016990-ot1wi3xi 468 15 heart heart NN cord-016990-ot1wi3xi 468 16 , , , cord-016990-ot1wi3xi 468 17 brain brain NN cord-016990-ot1wi3xi 468 18 , , , cord-016990-ot1wi3xi 468 19 kidneys kidney NNS cord-016990-ot1wi3xi 468 20 , , , cord-016990-ot1wi3xi 468 21 and and CC cord-016990-ot1wi3xi 468 22 muscle muscle NN cord-016990-ot1wi3xi 468 23 . . . cord-016990-ot1wi3xi 469 1 Influenzaviruses influenzaviruse NNS cord-016990-ot1wi3xi 469 2 belong belong VBP cord-016990-ot1wi3xi 469 3 to to IN cord-016990-ot1wi3xi 469 4 the the DT cord-016990-ot1wi3xi 469 5 Orthomyxoviridae Orthomyxoviridae NNP cord-016990-ot1wi3xi 469 6 family family NN cord-016990-ot1wi3xi 469 7 , , , cord-016990-ot1wi3xi 469 8 which which WDT cord-016990-ot1wi3xi 469 9 consists consist VBZ cord-016990-ot1wi3xi 469 10 of of IN cord-016990-ot1wi3xi 469 11 four four CD cord-016990-ot1wi3xi 469 12 genera genus NNS cord-016990-ot1wi3xi 469 13 that that WDT cord-016990-ot1wi3xi 469 14 include include VBP cord-016990-ot1wi3xi 469 15 the the DT cord-016990-ot1wi3xi 469 16 two two CD cord-016990-ot1wi3xi 469 17 important important JJ cord-016990-ot1wi3xi 469 18 influenza influenza NN cord-016990-ot1wi3xi 469 19 viruses viruse VBZ cord-016990-ot1wi3xi 469 20 types type NNS cord-016990-ot1wi3xi 469 21 A a VBP cord-016990-ot1wi3xi 469 22 and and CC cord-016990-ot1wi3xi 469 23 B b NN cord-016990-ot1wi3xi 469 24 associated associate VBN cord-016990-ot1wi3xi 469 25 with with IN cord-016990-ot1wi3xi 469 26 significant significant JJ cord-016990-ot1wi3xi 469 27 human human JJ cord-016990-ot1wi3xi 469 28 disease disease NN cord-016990-ot1wi3xi 469 29 . . . cord-016990-ot1wi3xi 470 1 179 179 CD cord-016990-ot1wi3xi 470 2 , , , cord-016990-ot1wi3xi 470 3 180 180 CD cord-016990-ot1wi3xi 470 4 Influenza Influenza NNP cord-016990-ot1wi3xi 470 5 A a DT cord-016990-ot1wi3xi 470 6 viruses virus NNS cord-016990-ot1wi3xi 470 7 are be VBP cord-016990-ot1wi3xi 470 8 further further RB cord-016990-ot1wi3xi 470 9 classified classify VBN cord-016990-ot1wi3xi 470 10 into into IN cord-016990-ot1wi3xi 470 11 subtypes subtype NNS cord-016990-ot1wi3xi 470 12 based base VBN cord-016990-ot1wi3xi 470 13 on on IN cord-016990-ot1wi3xi 470 14 the the DT cord-016990-ot1wi3xi 470 15 antigenicity antigenicity NN cord-016990-ot1wi3xi 470 16 of of IN cord-016990-ot1wi3xi 470 17 their -PRON- PRP$ cord-016990-ot1wi3xi 470 18 hemagglutinin hemagglutinin NNS cord-016990-ot1wi3xi 470 19 ( ( -LRB- cord-016990-ot1wi3xi 470 20 HA HA NNP cord-016990-ot1wi3xi 470 21 ) ) -RRB- cord-016990-ot1wi3xi 470 22 and and CC cord-016990-ot1wi3xi 470 23 neuraminidase neuraminidase NN cord-016990-ot1wi3xi 470 24 ( ( -LRB- cord-016990-ot1wi3xi 470 25 NA NA NNP cord-016990-ot1wi3xi 470 26 ) ) -RRB- cord-016990-ot1wi3xi 470 27 surface surface NN cord-016990-ot1wi3xi 470 28 glycoproteins glycoprotein NNS cord-016990-ot1wi3xi 470 29 . . . cord-016990-ot1wi3xi 471 1 Only only RB cord-016990-ot1wi3xi 471 2 one one CD cord-016990-ot1wi3xi 471 3 type type NN cord-016990-ot1wi3xi 471 4 of of IN cord-016990-ot1wi3xi 471 5 HA HA NNP cord-016990-ot1wi3xi 471 6 and and CC cord-016990-ot1wi3xi 471 7 one one CD cord-016990-ot1wi3xi 471 8 type type NN cord-016990-ot1wi3xi 471 9 of of IN cord-016990-ot1wi3xi 471 10 NA NA NNP cord-016990-ot1wi3xi 471 11 are be VBP cord-016990-ot1wi3xi 471 12 recognized recognize VBN cord-016990-ot1wi3xi 471 13 for for IN cord-016990-ot1wi3xi 471 14 influenza influenza NN cord-016990-ot1wi3xi 471 15 B. B. NNP cord-016990-ot1wi3xi 471 16 Influenza Influenza NNP cord-016990-ot1wi3xi 471 17 A A NNP cord-016990-ot1wi3xi 471 18 occurs occur VBZ cord-016990-ot1wi3xi 471 19 in in IN cord-016990-ot1wi3xi 471 20 both both DT cord-016990-ot1wi3xi 471 21 pandemic pandemic NN cord-016990-ot1wi3xi 471 22 and and CC cord-016990-ot1wi3xi 471 23 interpandemic interpandemic JJ cord-016990-ot1wi3xi 471 24 forms form NNS cord-016990-ot1wi3xi 471 25 . . . cord-016990-ot1wi3xi 472 1 Fortunately fortunately RB cord-016990-ot1wi3xi 472 2 , , , cord-016990-ot1wi3xi 472 3 pandemics pandemic NNS cord-016990-ot1wi3xi 472 4 , , , cord-016990-ot1wi3xi 472 5 defined define VBN cord-016990-ot1wi3xi 472 6 as as IN cord-016990-ot1wi3xi 472 7 worldwide worldwide JJ cord-016990-ot1wi3xi 472 8 outbreaks outbreak NNS cord-016990-ot1wi3xi 472 9 of of IN cord-016990-ot1wi3xi 472 10 severe severe JJ cord-016990-ot1wi3xi 472 11 disease disease NN cord-016990-ot1wi3xi 472 12 , , , cord-016990-ot1wi3xi 472 13 occur occur VBP cord-016990-ot1wi3xi 472 14 infrequently infrequently RB cord-016990-ot1wi3xi 472 15 . . . cord-016990-ot1wi3xi 473 1 Interpandemic Interpandemic NNP cord-016990-ot1wi3xi 473 2 influenza influenza NN cord-016990-ot1wi3xi 473 3 , , , cord-016990-ot1wi3xi 473 4 although although IN cord-016990-ot1wi3xi 473 5 less less RBR cord-016990-ot1wi3xi 473 6 extensive extensive JJ cord-016990-ot1wi3xi 473 7 in in IN cord-016990-ot1wi3xi 473 8 its -PRON- PRP$ cord-016990-ot1wi3xi 473 9 impact impact NN cord-016990-ot1wi3xi 473 10 , , , cord-016990-ot1wi3xi 473 11 occurs occur VBZ cord-016990-ot1wi3xi 473 12 virtually virtually RB cord-016990-ot1wi3xi 473 13 every every DT cord-016990-ot1wi3xi 473 14 year year NN cord-016990-ot1wi3xi 473 15 . . . cord-016990-ot1wi3xi 474 1 The the DT cord-016990-ot1wi3xi 474 2 epidemiologic epidemiologic JJ cord-016990-ot1wi3xi 474 3 pattern pattern NN cord-016990-ot1wi3xi 474 4 of of IN cord-016990-ot1wi3xi 474 5 influenza influenza NN cord-016990-ot1wi3xi 474 6 in in IN cord-016990-ot1wi3xi 474 7 humans human NNS cord-016990-ot1wi3xi 474 8 is be VBZ cord-016990-ot1wi3xi 474 9 related relate VBN cord-016990-ot1wi3xi 474 10 to to IN cord-016990-ot1wi3xi 474 11 two two CD cord-016990-ot1wi3xi 474 12 types type NNS cord-016990-ot1wi3xi 474 13 of of IN cord-016990-ot1wi3xi 474 14 antigenic antigenic JJ cord-016990-ot1wi3xi 474 15 variation variation NN cord-016990-ot1wi3xi 474 16 of of IN cord-016990-ot1wi3xi 474 17 its -PRON- PRP$ cord-016990-ot1wi3xi 474 18 envelope envelope NN cord-016990-ot1wi3xi 474 19 glycoproteins glycoprotein NNS cord-016990-ot1wi3xi 474 20 , , , cord-016990-ot1wi3xi 474 21 namely namely RB cord-016990-ot1wi3xi 474 22 antigenic antigenic JJ cord-016990-ot1wi3xi 474 23 drift drift NN cord-016990-ot1wi3xi 474 24 and and CC cord-016990-ot1wi3xi 474 25 antigenic antigenic JJ cord-016990-ot1wi3xi 474 26 shift shift NN cord-016990-ot1wi3xi 474 27 . . . cord-016990-ot1wi3xi 475 1 During during IN cord-016990-ot1wi3xi 475 2 antigenic antigenic JJ cord-016990-ot1wi3xi 475 3 drift drift NN cord-016990-ot1wi3xi 475 4 , , , cord-016990-ot1wi3xi 475 5 new new JJ cord-016990-ot1wi3xi 475 6 strains strain NNS cord-016990-ot1wi3xi 475 7 related relate VBN cord-016990-ot1wi3xi 475 8 to to IN cord-016990-ot1wi3xi 475 9 those those DT cord-016990-ot1wi3xi 475 10 circulating circulate VBG cord-016990-ot1wi3xi 475 11 in in IN cord-016990-ot1wi3xi 475 12 previous previous JJ cord-016990-ot1wi3xi 475 13 epidemics epidemic NNS cord-016990-ot1wi3xi 475 14 evolve evolve VBP cord-016990-ot1wi3xi 475 15 by by IN cord-016990-ot1wi3xi 475 16 accumulation accumulation NN cord-016990-ot1wi3xi 475 17 of of IN cord-016990-ot1wi3xi 475 18 point point NN cord-016990-ot1wi3xi 475 19 mutations mutation NNS cord-016990-ot1wi3xi 475 20 in in IN cord-016990-ot1wi3xi 475 21 the the DT cord-016990-ot1wi3xi 475 22 surface surface NN cord-016990-ot1wi3xi 475 23 glycoproteins glycoprotein NNS cord-016990-ot1wi3xi 475 24 . . . cord-016990-ot1wi3xi 476 1 This this DT cord-016990-ot1wi3xi 476 2 enables enable VBZ cord-016990-ot1wi3xi 476 3 the the DT cord-016990-ot1wi3xi 476 4 virus virus NN cord-016990-ot1wi3xi 476 5 to to TO cord-016990-ot1wi3xi 476 6 evade evade VB cord-016990-ot1wi3xi 476 7 the the DT cord-016990-ot1wi3xi 476 8 immune immune JJ cord-016990-ot1wi3xi 476 9 system system NN cord-016990-ot1wi3xi 476 10 leading lead VBG cord-016990-ot1wi3xi 476 11 to to IN cord-016990-ot1wi3xi 476 12 repeated repeat VBN cord-016990-ot1wi3xi 476 13 outbreaks outbreak NNS cord-016990-ot1wi3xi 476 14 during during IN cord-016990-ot1wi3xi 476 15 interpandemic interpandemic JJ cord-016990-ot1wi3xi 476 16 years year NNS cord-016990-ot1wi3xi 476 17 . . . cord-016990-ot1wi3xi 477 1 Antigenic antigenic JJ cord-016990-ot1wi3xi 477 2 shift shift NN cord-016990-ot1wi3xi 477 3 occurs occur VBZ cord-016990-ot1wi3xi 477 4 with with IN cord-016990-ot1wi3xi 477 5 the the DT cord-016990-ot1wi3xi 477 6 emergence emergence NN cord-016990-ot1wi3xi 477 7 of of IN cord-016990-ot1wi3xi 477 8 a a DT cord-016990-ot1wi3xi 477 9 " " `` cord-016990-ot1wi3xi 477 10 new new JJ cord-016990-ot1wi3xi 477 11 " " '' cord-016990-ot1wi3xi 477 12 potentially potentially RB cord-016990-ot1wi3xi 477 13 pandemic pandemic JJ cord-016990-ot1wi3xi 477 14 , , , cord-016990-ot1wi3xi 477 15 influenza influenza NN cord-016990-ot1wi3xi 477 16 A a DT cord-016990-ot1wi3xi 477 17 virus virus NN cord-016990-ot1wi3xi 477 18 that that WDT cord-016990-ot1wi3xi 477 19 possesses possess VBZ cord-016990-ot1wi3xi 477 20 a a DT cord-016990-ot1wi3xi 477 21 novel novel NN cord-016990-ot1wi3xi 477 22 HA HA NNP cord-016990-ot1wi3xi 477 23 alone alone RB cord-016990-ot1wi3xi 477 24 or or CC cord-016990-ot1wi3xi 477 25 in in IN cord-016990-ot1wi3xi 477 26 combination combination NN cord-016990-ot1wi3xi 477 27 with with IN cord-016990-ot1wi3xi 477 28 a a DT cord-016990-ot1wi3xi 477 29 novel novel JJ cord-016990-ot1wi3xi 477 30 NA NA NNP cord-016990-ot1wi3xi 477 31 . . . cord-016990-ot1wi3xi 478 1 There there EX cord-016990-ot1wi3xi 478 2 are be VBP cord-016990-ot1wi3xi 478 3 16 16 CD cord-016990-ot1wi3xi 478 4 recognized recognize VBN cord-016990-ot1wi3xi 478 5 HA HA NNP cord-016990-ot1wi3xi 478 6 subtypes subtype NNS cord-016990-ot1wi3xi 478 7 and and CC cord-016990-ot1wi3xi 478 8 nine nine CD cord-016990-ot1wi3xi 478 9 NA NA NNP cord-016990-ot1wi3xi 478 10 SUbtypes SUbtypes NNPS cord-016990-ot1wi3xi 478 11 of of IN cord-016990-ot1wi3xi 478 12 influenza influenza NN cord-016990-ot1wi3xi 478 13 A a DT cord-016990-ot1wi3xi 478 14 virus virus NN cord-016990-ot1wi3xi 478 15 . . . cord-016990-ot1wi3xi 479 1 Viruses virus NNS cord-016990-ot1wi3xi 479 2 from from IN cord-016990-ot1wi3xi 479 3 all all DT cord-016990-ot1wi3xi 479 4 HA HA NNP cord-016990-ot1wi3xi 479 5 and and CC cord-016990-ot1wi3xi 479 6 NA NA NNP cord-016990-ot1wi3xi 479 7 SUbtypes SUbtypes NNPS cord-016990-ot1wi3xi 479 8 have have VBP cord-016990-ot1wi3xi 479 9 been be VBN cord-016990-ot1wi3xi 479 10 recovered recover VBN cord-016990-ot1wi3xi 479 11 from from IN cord-016990-ot1wi3xi 479 12 aquatic aquatic JJ cord-016990-ot1wi3xi 479 13 birds bird NNS cord-016990-ot1wi3xi 479 14 , , , cord-016990-ot1wi3xi 479 15 but but CC cord-016990-ot1wi3xi 479 16 only only RB cord-016990-ot1wi3xi 479 17 three three CD cord-016990-ot1wi3xi 479 18 HA HA NNP cord-016990-ot1wi3xi 479 19 subtypes subtype NNS cord-016990-ot1wi3xi 479 20 ( ( -LRB- cord-016990-ot1wi3xi 479 21 HI hi UH cord-016990-ot1wi3xi 479 22 , , , cord-016990-ot1wi3xi 479 23 H2 H2 NNP cord-016990-ot1wi3xi 479 24 , , , cord-016990-ot1wi3xi 479 25 and and CC cord-016990-ot1wi3xi 479 26 H3 H3 NNP cord-016990-ot1wi3xi 479 27 ) ) -RRB- cord-016990-ot1wi3xi 479 28 and and CC cord-016990-ot1wi3xi 479 29 two two CD cord-016990-ot1wi3xi 479 30 NA NA NNP cord-016990-ot1wi3xi 479 31 SUbtypes SUbtypes NNPS cord-016990-ot1wi3xi 479 32 ( ( -LRB- cord-016990-ot1wi3xi 479 33 Nl Nl NNP cord-016990-ot1wi3xi 479 34 and and CC cord-016990-ot1wi3xi 479 35 N2 N2 NNP cord-016990-ot1wi3xi 479 36 ) ) -RRB- cord-016990-ot1wi3xi 479 37 have have VBP cord-016990-ot1wi3xi 479 38 established establish VBN cord-016990-ot1wi3xi 479 39 stable stable JJ cord-016990-ot1wi3xi 479 40 lineages lineage NNS cord-016990-ot1wi3xi 479 41 in in IN cord-016990-ot1wi3xi 479 42 the the DT cord-016990-ot1wi3xi 479 43 human human JJ cord-016990-ot1wi3xi 479 44 population population NN cord-016990-ot1wi3xi 479 45 since since IN cord-016990-ot1wi3xi 479 46 1918 1918 CD cord-016990-ot1wi3xi 479 47 . . . cord-016990-ot1wi3xi 480 1 Since since IN cord-016990-ot1wi3xi 480 2 1997 1997 CD cord-016990-ot1wi3xi 480 3 , , , cord-016990-ot1wi3xi 480 4 widespread widespread JJ cord-016990-ot1wi3xi 480 5 avian avian JJ cord-016990-ot1wi3xi 480 6 infection infection NN cord-016990-ot1wi3xi 480 7 with with IN cord-016990-ot1wi3xi 480 8 influenza influenza NN cord-016990-ot1wi3xi 480 9 A a NN cord-016990-ot1wi3xi 480 10 ( ( -LRB- cord-016990-ot1wi3xi 480 11 H5N1 H5N1 NNP cord-016990-ot1wi3xi 480 12 ) ) -RRB- cord-016990-ot1wi3xi 480 13 and and CC cord-016990-ot1wi3xi 480 14 associated associate VBN cord-016990-ot1wi3xi 480 15 clusters cluster NNS cord-016990-ot1wi3xi 480 16 of of IN cord-016990-ot1wi3xi 480 17 human human JJ cord-016990-ot1wi3xi 480 18 disease disease NN cord-016990-ot1wi3xi 480 19 have have VBP cord-016990-ot1wi3xi 480 20 aroused arouse VBN cord-016990-ot1wi3xi 480 21 concern concern NN cord-016990-ot1wi3xi 480 22 about about IN cord-016990-ot1wi3xi 480 23 the the DT cord-016990-ot1wi3xi 480 24 threat threat NN cord-016990-ot1wi3xi 480 25 of of IN cord-016990-ot1wi3xi 480 26 a a DT cord-016990-ot1wi3xi 480 27 pandemic pandemic NN cord-016990-ot1wi3xi 480 28 , , , cord-016990-ot1wi3xi 480 29 and and CC cord-016990-ot1wi3xi 480 30 attention attention NN cord-016990-ot1wi3xi 480 31 has have VBZ cord-016990-ot1wi3xi 480 32 been be VBN cord-016990-ot1wi3xi 480 33 appropriately appropriately RB cord-016990-ot1wi3xi 480 34 focused focus VBN cord-016990-ot1wi3xi 480 35 on on IN cord-016990-ot1wi3xi 480 36 control control NN cord-016990-ot1wi3xi 480 37 measures measure NNS cord-016990-ot1wi3xi 480 38 to to TO cord-016990-ot1wi3xi 480 39 deal deal VB cord-016990-ot1wi3xi 480 40 with with IN cord-016990-ot1wi3xi 480 41 such such PDT cord-016990-ot1wi3xi 480 42 an an DT cord-016990-ot1wi3xi 480 43 event event NN cord-016990-ot1wi3xi 480 44 . . . cord-016990-ot1wi3xi 481 1 All all DT cord-016990-ot1wi3xi 481 2 Influenzaviruses Influenzaviruses NNPS cord-016990-ot1wi3xi 481 3 have have VBP cord-016990-ot1wi3xi 481 4 a a DT cord-016990-ot1wi3xi 481 5 segmented segmented JJ cord-016990-ot1wi3xi 481 6 , , , cord-016990-ot1wi3xi 481 7 negative negative JJ cord-016990-ot1wi3xi 481 8 - - HYPH cord-016990-ot1wi3xi 481 9 sense sense NN cord-016990-ot1wi3xi 481 10 RNA RNA NNP cord-016990-ot1wi3xi 481 11 core core NN cord-016990-ot1wi3xi 481 12 surrounded surround VBN cord-016990-ot1wi3xi 481 13 by by IN cord-016990-ot1wi3xi 481 14 a a DT cord-016990-ot1wi3xi 481 15 lipid lipid NN cord-016990-ot1wi3xi 481 16 envelope envelope NN cord-016990-ot1wi3xi 481 17 . . . cord-016990-ot1wi3xi 482 1 Influenzavirus influenzavirus NN cord-016990-ot1wi3xi 482 2 particles particle NNS cord-016990-ot1wi3xi 482 3 are be VBP cord-016990-ot1wi3xi 482 4 pleomorphic pleomorphic JJ cord-016990-ot1wi3xi 482 5 . . . cord-016990-ot1wi3xi 483 1 Among among IN cord-016990-ot1wi3xi 483 2 isolates isolate NNS cord-016990-ot1wi3xi 483 3 that that WDT cord-016990-ot1wi3xi 483 4 have have VBP cord-016990-ot1wi3xi 483 5 undergone undergo VBN cord-016990-ot1wi3xi 483 6 a a DT cord-016990-ot1wi3xi 483 7 limited limited JJ cord-016990-ot1wi3xi 483 8 number number NN cord-016990-ot1wi3xi 483 9 of of IN cord-016990-ot1wi3xi 483 10 passages passage NNS cord-016990-ot1wi3xi 483 11 in in IN cord-016990-ot1wi3xi 483 12 cell cell NN cord-016990-ot1wi3xi 483 13 culture culture NN cord-016990-ot1wi3xi 483 14 or or CC cord-016990-ot1wi3xi 483 15 eggs egg NNS cord-016990-ot1wi3xi 483 16 , , , cord-016990-ot1wi3xi 483 17 more more RBR cord-016990-ot1wi3xi 483 18 filamentous filamentous JJ cord-016990-ot1wi3xi 483 19 than than IN cord-016990-ot1wi3xi 483 20 spherical spherical JJ cord-016990-ot1wi3xi 483 21 particles particle NNS cord-016990-ot1wi3xi 483 22 are be VBP cord-016990-ot1wi3xi 483 23 seen see VBN cord-016990-ot1wi3xi 483 24 . . . cord-016990-ot1wi3xi 484 1 Spherical spherical JJ cord-016990-ot1wi3xi 484 2 morphology morphology NN cord-016990-ot1wi3xi 484 3 becomes become VBZ cord-016990-ot1wi3xi 484 4 dominant dominant JJ cord-016990-ot1wi3xi 484 5 when when WRB cord-016990-ot1wi3xi 484 6 the the DT cord-016990-ot1wi3xi 484 7 virus virus NN cord-016990-ot1wi3xi 484 8 is be VBZ cord-016990-ot1wi3xi 484 9 extensively extensively RB cord-016990-ot1wi3xi 484 10 passaged passage VBN cord-016990-ot1wi3xi 484 11 in in IN cord-016990-ot1wi3xi 484 12 the the DT cord-016990-ot1wi3xi 484 13 laboratory laboratory NN cord-016990-ot1wi3xi 484 14 . . . cord-016990-ot1wi3xi 485 1 A a DT cord-016990-ot1wi3xi 485 2 10-to 10-to CD cord-016990-ot1wi3xi 485 3 12-nm 12-nm CD cord-016990-ot1wi3xi 485 4 layer layer NN cord-016990-ot1wi3xi 485 5 of of IN cord-016990-ot1wi3xi 485 6 HA HA NNP cord-016990-ot1wi3xi 485 7 ( ( -LRB- cord-016990-ot1wi3xi 485 8 rod rod NN cord-016990-ot1wi3xi 485 9 - - HYPH cord-016990-ot1wi3xi 485 10 shaped shape VBN cord-016990-ot1wi3xi 485 11 ) ) -RRB- cord-016990-ot1wi3xi 485 12 and and CC cord-016990-ot1wi3xi 485 13 NA NA NNP cord-016990-ot1wi3xi 485 14 ( ( -LRB- cord-016990-ot1wi3xi 485 15 mushroomshaped mushroomshaped NNP cord-016990-ot1wi3xi 485 16 ) ) -RRB- cord-016990-ot1wi3xi 485 17 spikes spike NNS cord-016990-ot1wi3xi 485 18 project project NN cord-016990-ot1wi3xi 485 19 radially radially RB cord-016990-ot1wi3xi 485 20 on on IN cord-016990-ot1wi3xi 485 21 the the DT cord-016990-ot1wi3xi 485 22 surface surface NN cord-016990-ot1wi3xi 485 23 of of IN cord-016990-ot1wi3xi 485 24 the the DT cord-016990-ot1wi3xi 485 25 influenza influenza NN cord-016990-ot1wi3xi 485 26 A a NN cord-016990-ot1wi3xi 485 27 and and CC cord-016990-ot1wi3xi 485 28 B b NN cord-016990-ot1wi3xi 485 29 viruses virus NNS cord-016990-ot1wi3xi 485 30 . . . cord-016990-ot1wi3xi 486 1 Hemagglutinin Hemagglutinin NNP cord-016990-ot1wi3xi 486 2 facilitates facilitate VBZ cord-016990-ot1wi3xi 486 3 entry entry NN cord-016990-ot1wi3xi 486 4 of of IN cord-016990-ot1wi3xi 486 5 virus virus NN cord-016990-ot1wi3xi 486 6 into into IN cord-016990-ot1wi3xi 486 7 host host NN cord-016990-ot1wi3xi 486 8 cells cell NNS cord-016990-ot1wi3xi 486 9 through through IN cord-016990-ot1wi3xi 486 10 its -PRON- PRP$ cord-016990-ot1wi3xi 486 11 attachment attachment NN cord-016990-ot1wi3xi 486 12 to to IN cord-016990-ot1wi3xi 486 13 sialic sialic JJ cord-016990-ot1wi3xi 486 14 - - HYPH cord-016990-ot1wi3xi 486 15 acid acid NN cord-016990-ot1wi3xi 486 16 receptors receptor NNS cord-016990-ot1wi3xi 486 17 . . . cord-016990-ot1wi3xi 487 1 Because because IN cord-016990-ot1wi3xi 487 2 neutralizing neutralize VBG cord-016990-ot1wi3xi 487 3 antibodies antibody NNS cord-016990-ot1wi3xi 487 4 are be VBP cord-016990-ot1wi3xi 487 5 directed direct VBN cord-016990-ot1wi3xi 487 6 against against IN cord-016990-ot1wi3xi 487 7 this this DT cord-016990-ot1wi3xi 487 8 antigen antigen NN cord-016990-ot1wi3xi 487 9 , , , cord-016990-ot1wi3xi 487 10 it -PRON- PRP cord-016990-ot1wi3xi 487 11 is be VBZ cord-016990-ot1wi3xi 487 12 a a DT cord-016990-ot1wi3xi 487 13 critical critical JJ cord-016990-ot1wi3xi 487 14 component component NN cord-016990-ot1wi3xi 487 15 of of IN cord-016990-ot1wi3xi 487 16 current current JJ cord-016990-ot1wi3xi 487 17 influenza influenza NN cord-016990-ot1wi3xi 487 18 vaccines vaccine NNS cord-016990-ot1wi3xi 487 19 . . . cord-016990-ot1wi3xi 488 1 Neuraminidase Neuraminidase NNP cord-016990-ot1wi3xi 488 2 , , , cord-016990-ot1wi3xi 488 3 the the DT cord-016990-ot1wi3xi 488 4 second second JJ cord-016990-ot1wi3xi 488 5 major major JJ cord-016990-ot1wi3xi 488 6 antigenic antigenic JJ cord-016990-ot1wi3xi 488 7 determinant determinant NN cord-016990-ot1wi3xi 488 8 , , , cord-016990-ot1wi3xi 488 9 catalyzes catalyze VBZ cord-016990-ot1wi3xi 488 10 the the DT cord-016990-ot1wi3xi 488 11 cleavage cleavage NN cord-016990-ot1wi3xi 488 12 of of IN cord-016990-ot1wi3xi 488 13 glycosidic glycosidic JJ cord-016990-ot1wi3xi 488 14 linkages linkage NNS cord-016990-ot1wi3xi 488 15 to to IN cord-016990-ot1wi3xi 488 16 sialic sialic JJ cord-016990-ot1wi3xi 488 17 acid acid NN cord-016990-ot1wi3xi 488 18 and and CC cord-016990-ot1wi3xi 488 19 the the DT cord-016990-ot1wi3xi 488 20 release release NN cord-016990-ot1wi3xi 488 21 of of IN cord-016990-ot1wi3xi 488 22 progeny progeny JJ cord-016990-ot1wi3xi 488 23 virions virion NNS cord-016990-ot1wi3xi 488 24 from from IN cord-016990-ot1wi3xi 488 25 infected infected JJ cord-016990-ot1wi3xi 488 26 cells cell NNS cord-016990-ot1wi3xi 488 27 . . . cord-016990-ot1wi3xi 489 1 Accordingly accordingly RB cord-016990-ot1wi3xi 489 2 , , , cord-016990-ot1wi3xi 489 3 it -PRON- PRP cord-016990-ot1wi3xi 489 4 has have VBZ cord-016990-ot1wi3xi 489 5 become become VBN cord-016990-ot1wi3xi 489 6 an an DT cord-016990-ot1wi3xi 489 7 important important JJ cord-016990-ot1wi3xi 489 8 target target NN cord-016990-ot1wi3xi 489 9 for for IN cord-016990-ot1wi3xi 489 10 drug drug NN cord-016990-ot1wi3xi 489 11 inhibitors inhibitor NNS cord-016990-ot1wi3xi 489 12 such such JJ cord-016990-ot1wi3xi 489 13 as as IN cord-016990-ot1wi3xi 489 14 oseltamivir oseltamivir NNP cord-016990-ot1wi3xi 489 15 and and CC cord-016990-ot1wi3xi 489 16 zanamivir zanamivir NNP cord-016990-ot1wi3xi 489 17 . . . cord-016990-ot1wi3xi 490 1 The the DT cord-016990-ot1wi3xi 490 2 M2 M2 NNP cord-016990-ot1wi3xi 490 3 surface surface NN cord-016990-ot1wi3xi 490 4 component component NN cord-016990-ot1wi3xi 490 5 and and CC cord-016990-ot1wi3xi 490 6 channel channel NN cord-016990-ot1wi3xi 490 7 of of IN cord-016990-ot1wi3xi 490 8 influenza influenza NN cord-016990-ot1wi3xi 490 9 A A NNP cord-016990-ot1wi3xi 490 10 ( ( -LRB- cord-016990-ot1wi3xi 490 11 not not RB cord-016990-ot1wi3xi 490 12 present present JJ cord-016990-ot1wi3xi 490 13 in in IN cord-016990-ot1wi3xi 490 14 influenza influenza NN cord-016990-ot1wi3xi 490 15 B B NNP cord-016990-ot1wi3xi 490 16 virus virus NN cord-016990-ot1wi3xi 490 17 ) ) -RRB- cord-016990-ot1wi3xi 490 18 regulates regulate VBZ cord-016990-ot1wi3xi 490 19 the the DT cord-016990-ot1wi3xi 490 20 internal internal JJ cord-016990-ot1wi3xi 490 21 pH ph NN cord-016990-ot1wi3xi 490 22 of of IN cord-016990-ot1wi3xi 490 23 the the DT cord-016990-ot1wi3xi 490 24 virus virus NN cord-016990-ot1wi3xi 490 25 and and CC cord-016990-ot1wi3xi 490 26 is be VBZ cord-016990-ot1wi3xi 490 27 blocked block VBN cord-016990-ot1wi3xi 490 28 by by IN cord-016990-ot1wi3xi 490 29 the the DT cord-016990-ot1wi3xi 490 30 antiviral antiviral JJ cord-016990-ot1wi3xi 490 31 drug drug NN cord-016990-ot1wi3xi 490 32 amantadine amantadine NNP cord-016990-ot1wi3xi 490 33 . . . cord-016990-ot1wi3xi 491 1 Influenzaviruses Influenzaviruses NNP cord-016990-ot1wi3xi 491 2 are be VBP cord-016990-ot1wi3xi 491 3 spread spread VBN cord-016990-ot1wi3xi 491 4 person person NN cord-016990-ot1wi3xi 491 5 - - HYPH cord-016990-ot1wi3xi 491 6 to to IN cord-016990-ot1wi3xi 491 7 - - HYPH cord-016990-ot1wi3xi 491 8 person person NN cord-016990-ot1wi3xi 491 9 primarily primarily RB cord-016990-ot1wi3xi 491 10 through through IN cord-016990-ot1wi3xi 491 11 the the DT cord-016990-ot1wi3xi 491 12 coughing coughing NN cord-016990-ot1wi3xi 491 13 and and CC cord-016990-ot1wi3xi 491 14 sneezing sneezing NN cord-016990-ot1wi3xi 491 15 of of IN cord-016990-ot1wi3xi 491 16 infected infected JJ cord-016990-ot1wi3xi 491 17 persons person NNS cord-016990-ot1wi3xi 491 18 . . . cord-016990-ot1wi3xi 492 1 The the DT cord-016990-ot1wi3xi 492 2 typical typical JJ cord-016990-ot1wi3xi 492 3 incubation incubation NN cord-016990-ot1wi3xi 492 4 period period NN cord-016990-ot1wi3xi 492 5 for for IN cord-016990-ot1wi3xi 492 6 influenza influenza NN cord-016990-ot1wi3xi 492 7 is be VBZ cord-016990-ot1wi3xi 492 8 1 1 CD cord-016990-ot1wi3xi 492 9 to to IN cord-016990-ot1wi3xi 492 10 4 4 CD cord-016990-ot1wi3xi 492 11 days day NNS cord-016990-ot1wi3xi 492 12 , , , cord-016990-ot1wi3xi 492 13 with with IN cord-016990-ot1wi3xi 492 14 an an DT cord-016990-ot1wi3xi 492 15 average average NN cord-016990-ot1wi3xi 492 16 of of IN cord-016990-ot1wi3xi 492 17 2 2 CD cord-016990-ot1wi3xi 492 18 days day NNS cord-016990-ot1wi3xi 492 19 . . . cord-016990-ot1wi3xi 493 1 Adults adult NNS cord-016990-ot1wi3xi 493 2 can can MD cord-016990-ot1wi3xi 493 3 be be VB cord-016990-ot1wi3xi 493 4 infectious infectious JJ cord-016990-ot1wi3xi 493 5 from from IN cord-016990-ot1wi3xi 493 6 the the DT cord-016990-ot1wi3xi 493 7 day day NN cord-016990-ot1wi3xi 493 8 before before IN cord-016990-ot1wi3xi 493 9 symptoms symptom NNS cord-016990-ot1wi3xi 493 10 begin begin VBP cord-016990-ot1wi3xi 493 11 through through IN cord-016990-ot1wi3xi 493 12 approximately approximately RB cord-016990-ot1wi3xi 493 13 5 5 CD cord-016990-ot1wi3xi 493 14 days day NNS cord-016990-ot1wi3xi 493 15 after after IN cord-016990-ot1wi3xi 493 16 illness illness NN cord-016990-ot1wi3xi 493 17 onset onset NN cord-016990-ot1wi3xi 493 18 . . . cord-016990-ot1wi3xi 494 1 Children child NNS cord-016990-ot1wi3xi 494 2 can can MD cord-016990-ot1wi3xi 494 3 be be VB cord-016990-ot1wi3xi 494 4 infectious infectious JJ cord-016990-ot1wi3xi 494 5 for for IN cord-016990-ot1wi3xi 494 6 ~1O ~1o JJ cord-016990-ot1wi3xi 494 7 days day NNS cord-016990-ot1wi3xi 494 8 , , , cord-016990-ot1wi3xi 494 9 and and CC cord-016990-ot1wi3xi 494 10 young young JJ cord-016990-ot1wi3xi 494 11 children child NNS cord-016990-ot1wi3xi 494 12 can can MD cord-016990-ot1wi3xi 494 13 shed shed VB cord-016990-ot1wi3xi 494 14 virus virus NN cord-016990-ot1wi3xi 494 15 for for IN cord-016990-ot1wi3xi 494 16 several several JJ cord-016990-ot1wi3xi 494 17 days day NNS cord-016990-ot1wi3xi 494 18 before before IN cord-016990-ot1wi3xi 494 19 their -PRON- PRP$ cord-016990-ot1wi3xi 494 20 illness illness NN cord-016990-ot1wi3xi 494 21 onset onset NN cord-016990-ot1wi3xi 494 22 . . . cord-016990-ot1wi3xi 495 1 Severely severely RB cord-016990-ot1wi3xi 495 2 immunocompromised immunocompromised JJ cord-016990-ot1wi3xi 495 3 persons person NNS cord-016990-ot1wi3xi 495 4 can can MD cord-016990-ot1wi3xi 495 5 shed shed VB cord-016990-ot1wi3xi 495 6 virus virus NN cord-016990-ot1wi3xi 495 7 for for IN cord-016990-ot1wi3xi 495 8 weeks week NNS cord-016990-ot1wi3xi 495 9 or or CC cord-016990-ot1wi3xi 495 10 months month NNS cord-016990-ot1wi3xi 495 11 . . . cord-016990-ot1wi3xi 496 1 Uncomplicated uncomplicated JJ cord-016990-ot1wi3xi 496 2 influenza influenza NN cord-016990-ot1wi3xi 496 3 illness illness NN cord-016990-ot1wi3xi 496 4 is be VBZ cord-016990-ot1wi3xi 496 5 characterized characterize VBN cord-016990-ot1wi3xi 496 6 by by IN cord-016990-ot1wi3xi 496 7 the the DT cord-016990-ot1wi3xi 496 8 abrupt abrupt JJ cord-016990-ot1wi3xi 496 9 onset onset NN cord-016990-ot1wi3xi 496 10 of of IN cord-016990-ot1wi3xi 496 11 constitutional constitutional JJ cord-016990-ot1wi3xi 496 12 and and CC cord-016990-ot1wi3xi 496 13 respiratory respiratory JJ cord-016990-ot1wi3xi 496 14 signs sign NNS cord-016990-ot1wi3xi 496 15 and and CC cord-016990-ot1wi3xi 496 16 symptoms symptom NNS cord-016990-ot1wi3xi 496 17 ( ( -LRB- cord-016990-ot1wi3xi 496 18 e.g. e.g. RB cord-016990-ot1wi3xi 496 19 , , , cord-016990-ot1wi3xi 496 20 fever fever NN cord-016990-ot1wi3xi 496 21 , , , cord-016990-ot1wi3xi 496 22 myalgia myalgia NN cord-016990-ot1wi3xi 496 23 , , , cord-016990-ot1wi3xi 496 24 headache headache NN cord-016990-ot1wi3xi 496 25 , , , cord-016990-ot1wi3xi 496 26 malaise malaise NN cord-016990-ot1wi3xi 496 27 , , , cord-016990-ot1wi3xi 496 28 nonproductive nonproductive JJ cord-016990-ot1wi3xi 496 29 cough cough NN cord-016990-ot1wi3xi 496 30 , , , cord-016990-ot1wi3xi 496 31 sore sore JJ cord-016990-ot1wi3xi 496 32 throat throat NN cord-016990-ot1wi3xi 496 33 , , , cord-016990-ot1wi3xi 496 34 and and CC cord-016990-ot1wi3xi 496 35 rhinitis rhinitis NN cord-016990-ot1wi3xi 496 36 ) ) -RRB- cord-016990-ot1wi3xi 496 37 . . . cord-016990-ot1wi3xi 497 1 Among among IN cord-016990-ot1wi3xi 497 2 children child NNS cord-016990-ot1wi3xi 497 3 , , , cord-016990-ot1wi3xi 497 4 otitis otitis NN cord-016990-ot1wi3xi 497 5 media medium NNS cord-016990-ot1wi3xi 497 6 , , , cord-016990-ot1wi3xi 497 7 nausea nausea NN cord-016990-ot1wi3xi 497 8 , , , cord-016990-ot1wi3xi 497 9 and and CC cord-016990-ot1wi3xi 497 10 vomiting vomiting NN cord-016990-ot1wi3xi 497 11 are be VBP cord-016990-ot1wi3xi 497 12 also also RB cord-016990-ot1wi3xi 497 13 commonly commonly RB cord-016990-ot1wi3xi 497 14 reported report VBN cord-016990-ot1wi3xi 497 15 with with IN cord-016990-ot1wi3xi 497 16 influenza influenza NN cord-016990-ot1wi3xi 497 17 illness illness NN cord-016990-ot1wi3xi 497 18 . . . cord-016990-ot1wi3xi 498 1 Respiratory respiratory JJ cord-016990-ot1wi3xi 498 2 illness illness NN cord-016990-ot1wi3xi 498 3 caused cause VBN cord-016990-ot1wi3xi 498 4 by by IN cord-016990-ot1wi3xi 498 5 influenza influenza NN cord-016990-ot1wi3xi 498 6 is be VBZ cord-016990-ot1wi3xi 498 7 difficult difficult JJ cord-016990-ot1wi3xi 498 8 to to TO cord-016990-ot1wi3xi 498 9 distinguish distinguish VB cord-016990-ot1wi3xi 498 10 from from IN cord-016990-ot1wi3xi 498 11 illnesses illness NNS cord-016990-ot1wi3xi 498 12 caused cause VBN cord-016990-ot1wi3xi 498 13 by by IN cord-016990-ot1wi3xi 498 14 other other JJ cord-016990-ot1wi3xi 498 15 respiratory respiratory JJ cord-016990-ot1wi3xi 498 16 pathogens pathogen NNS cord-016990-ot1wi3xi 498 17 on on IN cord-016990-ot1wi3xi 498 18 the the DT cord-016990-ot1wi3xi 498 19 basis basis NN cord-016990-ot1wi3xi 498 20 of of IN cord-016990-ot1wi3xi 498 21 symptoms symptom NNS cord-016990-ot1wi3xi 498 22 alone alone RB cord-016990-ot1wi3xi 498 23 . . . cord-016990-ot1wi3xi 499 1 Influenza Influenza NNP cord-016990-ot1wi3xi 499 2 typically typically RB cord-016990-ot1wi3xi 499 3 resolves resolve VBZ cord-016990-ot1wi3xi 499 4 after after IN cord-016990-ot1wi3xi 499 5 3 3 CD cord-016990-ot1wi3xi 499 6 to to TO cord-016990-ot1wi3xi 499 7 7 7 CD cord-016990-ot1wi3xi 499 8 days day NNS cord-016990-ot1wi3xi 499 9 in in IN cord-016990-ot1wi3xi 499 10 most most JJS cord-016990-ot1wi3xi 499 11 patients patient NNS cord-016990-ot1wi3xi 499 12 , , , cord-016990-ot1wi3xi 499 13 although although IN cord-016990-ot1wi3xi 499 14 cough cough NN cord-016990-ot1wi3xi 499 15 and and CC cord-016990-ot1wi3xi 499 16 malaise malaise NN cord-016990-ot1wi3xi 499 17 can can MD cord-016990-ot1wi3xi 499 18 persist persist VB cord-016990-ot1wi3xi 499 19 for for IN cord-016990-ot1wi3xi 499 20 > > $ cord-016990-ot1wi3xi 499 21 2 2 CD cord-016990-ot1wi3xi 499 22 weeks week NNS cord-016990-ot1wi3xi 499 23 . . . cord-016990-ot1wi3xi 500 1 Among among IN cord-016990-ot1wi3xi 500 2 certain certain JJ cord-016990-ot1wi3xi 500 3 persons person NNS cord-016990-ot1wi3xi 500 4 , , , cord-016990-ot1wi3xi 500 5 influenza influenza NN cord-016990-ot1wi3xi 500 6 can can MD cord-016990-ot1wi3xi 500 7 exacerbate exacerbate VB cord-016990-ot1wi3xi 500 8 underlying underlying JJ cord-016990-ot1wi3xi 500 9 medical medical JJ cord-016990-ot1wi3xi 500 10 conditions condition NNS cord-016990-ot1wi3xi 500 11 ( ( -LRB- cord-016990-ot1wi3xi 500 12 e.g. e.g. RB cord-016990-ot1wi3xi 500 13 , , , cord-016990-ot1wi3xi 500 14 pulmonary pulmonary JJ cord-016990-ot1wi3xi 500 15 or or CC cord-016990-ot1wi3xi 500 16 cardiac cardiac JJ cord-016990-ot1wi3xi 500 17 disease disease NN cord-016990-ot1wi3xi 500 18 ) ) -RRB- cord-016990-ot1wi3xi 500 19 , , , cord-016990-ot1wi3xi 500 20 lead lead VBP cord-016990-ot1wi3xi 500 21 to to IN cord-016990-ot1wi3xi 500 22 secondary secondary JJ cord-016990-ot1wi3xi 500 23 bacterial bacterial JJ cord-016990-ot1wi3xi 500 24 pneumonia pneumonia NN cord-016990-ot1wi3xi 500 25 or or CC cord-016990-ot1wi3xi 500 26 primary primary JJ cord-016990-ot1wi3xi 500 27 influenza influenza NN cord-016990-ot1wi3xi 500 28 viral viral JJ cord-016990-ot1wi3xi 500 29 pneumonia pneumonia NN cord-016990-ot1wi3xi 500 30 , , , cord-016990-ot1wi3xi 500 31 or or CC cord-016990-ot1wi3xi 500 32 occur occur VBP cord-016990-ot1wi3xi 500 33 as as IN cord-016990-ot1wi3xi 500 34 part part NN cord-016990-ot1wi3xi 500 35 of of IN cord-016990-ot1wi3xi 500 36 a a DT cord-016990-ot1wi3xi 500 37 co co NN cord-016990-ot1wi3xi 500 38 - - NN cord-016990-ot1wi3xi 500 39 infection infection NN cord-016990-ot1wi3xi 500 40 with with IN cord-016990-ot1wi3xi 500 41 other other JJ cord-016990-ot1wi3xi 500 42 viral viral JJ cord-016990-ot1wi3xi 500 43 or or CC cord-016990-ot1wi3xi 500 44 bacterial bacterial JJ cord-016990-ot1wi3xi 500 45 pathogens pathogen NNS cord-016990-ot1wi3xi 500 46 . . . cord-016990-ot1wi3xi 501 1 Young young JJ cord-016990-ot1wi3xi 501 2 children child NNS cord-016990-ot1wi3xi 501 3 with with IN cord-016990-ot1wi3xi 501 4 influenza influenza NN cord-016990-ot1wi3xi 501 5 infection infection NN cord-016990-ot1wi3xi 501 6 can can MD cord-016990-ot1wi3xi 501 7 have have VB cord-016990-ot1wi3xi 501 8 initial initial JJ cord-016990-ot1wi3xi 501 9 symptoms symptom NNS cord-016990-ot1wi3xi 501 10 that that WDT cord-016990-ot1wi3xi 501 11 mimic mimic VBP cord-016990-ot1wi3xi 501 12 bacterial bacterial JJ cord-016990-ot1wi3xi 501 13 sepsis sepsis NN cord-016990-ot1wi3xi 501 14 . . . cord-016990-ot1wi3xi 502 1 More More JJR cord-016990-ot1wi3xi 502 2 than than IN cord-016990-ot1wi3xi 502 3 20 20 CD cord-016990-ot1wi3xi 502 4 % % NN cord-016990-ot1wi3xi 502 5 of of IN cord-016990-ot1wi3xi 502 6 children child NNS cord-016990-ot1wi3xi 502 7 hospitalized hospitalize VBN cord-016990-ot1wi3xi 502 8 with with IN cord-016990-ot1wi3xi 502 9 influenza influenza NN cord-016990-ot1wi3xi 502 10 can can MD cord-016990-ot1wi3xi 502 11 have have VB cord-016990-ot1wi3xi 502 12 febrile febrile JJ cord-016990-ot1wi3xi 502 13 seizures seizure NNS cord-016990-ot1wi3xi 502 14 . . . cord-016990-ot1wi3xi 503 1 Influenza influenza NN cord-016990-ot1wi3xi 503 2 has have VBZ cord-016990-ot1wi3xi 503 3 also also RB cord-016990-ot1wi3xi 503 4 been be VBN cord-016990-ot1wi3xi 503 5 associated associate VBN cord-016990-ot1wi3xi 503 6 with with IN cord-016990-ot1wi3xi 503 7 encephalopathy encephalopathy NN cord-016990-ot1wi3xi 503 8 , , , cord-016990-ot1wi3xi 503 9 transverse transverse JJ cord-016990-ot1wi3xi 503 10 myelitis myelitis NN cord-016990-ot1wi3xi 503 11 , , , cord-016990-ot1wi3xi 503 12 Reye Reye NNP cord-016990-ot1wi3xi 503 13 syndrome syndrome NN cord-016990-ot1wi3xi 503 14 , , , cord-016990-ot1wi3xi 503 15 myositis myositis NN cord-016990-ot1wi3xi 503 16 , , , cord-016990-ot1wi3xi 503 17 myocarditis myocarditis NN cord-016990-ot1wi3xi 503 18 , , , cord-016990-ot1wi3xi 503 19 and and CC cord-016990-ot1wi3xi 503 20 pericarditis pericarditis NN cord-016990-ot1wi3xi 503 21 . . . cord-016990-ot1wi3xi 504 1 The the DT cord-016990-ot1wi3xi 504 2 risks risk NNS cord-016990-ot1wi3xi 504 3 for for IN cord-016990-ot1wi3xi 504 4 complications complication NNS cord-016990-ot1wi3xi 504 5 , , , cord-016990-ot1wi3xi 504 6 hospitalizations hospitalization NNS cord-016990-ot1wi3xi 504 7 , , , cord-016990-ot1wi3xi 504 8 and and CC cord-016990-ot1wi3xi 504 9 deaths death NNS cord-016990-ot1wi3xi 504 10 from from IN cord-016990-ot1wi3xi 504 11 influenza influenza NN cord-016990-ot1wi3xi 504 12 are be VBP cord-016990-ot1wi3xi 504 13 higher high JJR cord-016990-ot1wi3xi 504 14 among among IN cord-016990-ot1wi3xi 504 15 persons person NNS cord-016990-ot1wi3xi 504 16 aged age VBN cord-016990-ot1wi3xi 504 17 ~65 ~65 CD cord-016990-ot1wi3xi 504 18 years year NNS cord-016990-ot1wi3xi 504 19 , , , cord-016990-ot1wi3xi 504 20 young young JJ cord-016990-ot1wi3xi 504 21 children child NNS cord-016990-ot1wi3xi 504 22 , , , cord-016990-ot1wi3xi 504 23 and and CC cord-016990-ot1wi3xi 504 24 persons person NNS cord-016990-ot1wi3xi 504 25 of of IN cord-016990-ot1wi3xi 504 26 any any DT cord-016990-ot1wi3xi 504 27 age age NN cord-016990-ot1wi3xi 504 28 with with IN cord-016990-ot1wi3xi 504 29 certain certain JJ cord-016990-ot1wi3xi 504 30 underlying underlying JJ cord-016990-ot1wi3xi 504 31 health health NN cord-016990-ot1wi3xi 504 32 conditions condition NNS cord-016990-ot1wi3xi 504 33 than than IN cord-016990-ot1wi3xi 504 34 among among IN cord-016990-ot1wi3xi 504 35 healthy healthy JJ cord-016990-ot1wi3xi 504 36 older old JJR cord-016990-ot1wi3xi 504 37 children child NNS cord-016990-ot1wi3xi 504 38 and and CC cord-016990-ot1wi3xi 504 39 younger young JJR cord-016990-ot1wi3xi 504 40 adults adult NNS cord-016990-ot1wi3xi 504 41 . . . cord-016990-ot1wi3xi 505 1 Influenza influenza NN cord-016990-ot1wi3xi 505 2 - - HYPH cord-016990-ot1wi3xi 505 3 related relate VBN cord-016990-ot1wi3xi 505 4 deaths death NNS cord-016990-ot1wi3xi 505 5 can can MD cord-016990-ot1wi3xi 505 6 result result VB cord-016990-ot1wi3xi 505 7 from from IN cord-016990-ot1wi3xi 505 8 pneumonia pneumonia NN cord-016990-ot1wi3xi 505 9 or or CC cord-016990-ot1wi3xi 505 10 from from IN cord-016990-ot1wi3xi 505 11 exacerbations exacerbation NNS cord-016990-ot1wi3xi 505 12 of of IN cord-016990-ot1wi3xi 505 13 cardiopulmonary cardiopulmonary JJ cord-016990-ot1wi3xi 505 14 conditions condition NNS cord-016990-ot1wi3xi 505 15 and and CC cord-016990-ot1wi3xi 505 16 other other JJ cord-016990-ot1wi3xi 505 17 chronic chronic JJ cord-016990-ot1wi3xi 505 18 diseases disease NNS cord-016990-ot1wi3xi 505 19 . . . cord-016990-ot1wi3xi 506 1 The the DT cord-016990-ot1wi3xi 506 2 histopathologic histopathologic JJ cord-016990-ot1wi3xi 506 3 features feature NNS cord-016990-ot1wi3xi 506 4 of of IN cord-016990-ot1wi3xi 506 5 nonfatal nonfatal JJ cord-016990-ot1wi3xi 506 6 and and CC cord-016990-ot1wi3xi 506 7 fatal fatal JJ cord-016990-ot1wi3xi 506 8 influenza influenza NN cord-016990-ot1wi3xi 506 9 have have VBP cord-016990-ot1wi3xi 506 10 been be VBN cord-016990-ot1wi3xi 506 11 well well RB cord-016990-ot1wi3xi 506 12 described describe VBN cord-016990-ot1wi3xi 506 13 and and CC cord-016990-ot1wi3xi 506 14 include include VBP cord-016990-ot1wi3xi 506 15 necrotizing necrotize VBG cord-016990-ot1wi3xi 506 16 bronchitis bronchitis NN cord-016990-ot1wi3xi 506 17 , , , cord-016990-ot1wi3xi 506 18 thrombosis thrombosis NN cord-016990-ot1wi3xi 506 19 , , , cord-016990-ot1wi3xi 506 20 interstitial interstitial JJ cord-016990-ot1wi3xi 506 21 inflammation inflammation NN cord-016990-ot1wi3xi 506 22 , , , cord-016990-ot1wi3xi 506 23 hemorrhage hemorrhage NN cord-016990-ot1wi3xi 506 24 , , , cord-016990-ot1wi3xi 506 25 hyaline hyaline JJ cord-016990-ot1wi3xi 506 26 membrane membrane NN cord-016990-ot1wi3xi 506 27 formation formation NN cord-016990-ot1wi3xi 506 28 , , , cord-016990-ot1wi3xi 506 29 and and CC cord-016990-ot1wi3xi 506 30 intra intra JJ cord-016990-ot1wi3xi 506 31 alveolar alveolar NN cord-016990-ot1wi3xi 506 32 edema edema NN cord-016990-ot1wi3xi 506 33 ( ( -LRB- cord-016990-ot1wi3xi 506 34 Figs Figs NNP cord-016990-ot1wi3xi 506 35 . . . cord-016990-ot1wi3xi 506 36 11.8A 11.8a CD cord-016990-ot1wi3xi 506 37 , , , cord-016990-ot1wi3xi 506 38 B B NNP cord-016990-ot1wi3xi 506 39 , , , cord-016990-ot1wi3xi 506 40 11 11 CD cord-016990-ot1wi3xi 506 41 .9A .9A NFP cord-016990-ot1wi3xi 506 42 , , , cord-016990-ot1wi3xi 506 43 C C NNP cord-016990-ot1wi3xi 506 44 , , , cord-016990-ot1wi3xi 506 45 and and CC cord-016990-ot1wi3xi 506 46 11.10A 11.10a CD cord-016990-ot1wi3xi 506 47 ) ) -RRB- cord-016990-ot1wi3xi 506 48 . . . cord-016990-ot1wi3xi 507 1 105 105 CD cord-016990-ot1wi3xi 507 2 , , , cord-016990-ot1wi3xi 507 3 [ [ -LRB- cord-016990-ot1wi3xi 507 4 181 181 CD cord-016990-ot1wi3xi 507 5 ] ] -RRB- cord-016990-ot1wi3xi 507 6 [ [ -LRB- cord-016990-ot1wi3xi 507 7 182 182 CD cord-016990-ot1wi3xi 507 8 ] ] -RRB- cord-016990-ot1wi3xi 507 9 [ [ -LRB- cord-016990-ot1wi3xi 507 10 183 183 CD cord-016990-ot1wi3xi 507 11 ] ] -RRB- cord-016990-ot1wi3xi 507 12 [ [ -LRB- cord-016990-ot1wi3xi 507 13 184 184 CD cord-016990-ot1wi3xi 507 14 ] ] -RRB- cord-016990-ot1wi3xi 507 15 [ [ -LRB- cord-016990-ot1wi3xi 507 16 185 185 CD cord-016990-ot1wi3xi 507 17 ] ] -RRB- cord-016990-ot1wi3xi 507 18 [ [ -LRB- cord-016990-ot1wi3xi 507 19 186 186 CD cord-016990-ot1wi3xi 507 20 ] ] -RRB- cord-016990-ot1wi3xi 507 21 [ [ -LRB- cord-016990-ot1wi3xi 507 22 187 187 CD cord-016990-ot1wi3xi 507 23 ] ] -RRB- cord-016990-ot1wi3xi 507 24 [ [ -LRB- cord-016990-ot1wi3xi 507 25 188 188 CD cord-016990-ot1wi3xi 507 26 ] ] -RRB- cord-016990-ot1wi3xi 507 27 [ [ -LRB- cord-016990-ot1wi3xi 507 28 189 189 CD cord-016990-ot1wi3xi 507 29 ] ] -RRB- cord-016990-ot1wi3xi 507 30 [ [ -LRB- cord-016990-ot1wi3xi 507 31 190 190 CD cord-016990-ot1wi3xi 507 32 ] ] -RRB- cord-016990-ot1wi3xi 507 33 [ [ -LRB- cord-016990-ot1wi3xi 507 34 191 191 CD cord-016990-ot1wi3xi 507 35 ] ] -RRB- cord-016990-ot1wi3xi 508 1 The the DT cord-016990-ot1wi3xi 508 2 pathology pathology NN cord-016990-ot1wi3xi 508 3 is be VBZ cord-016990-ot1wi3xi 508 4 more more RBR cord-016990-ot1wi3xi 508 5 prominent prominent JJ cord-016990-ot1wi3xi 508 6 in in IN cord-016990-ot1wi3xi 508 7 larger large JJR cord-016990-ot1wi3xi 508 8 bronchi bronchi NN cord-016990-ot1wi3xi 508 9 , , , cord-016990-ot1wi3xi 508 10 and and CC cord-016990-ot1wi3xi 508 11 inflammation inflammation NN cord-016990-ot1wi3xi 508 12 may may MD cord-016990-ot1wi3xi 508 13 vary vary VB cord-016990-ot1wi3xi 508 14 in in IN cord-016990-ot1wi3xi 508 15 intensity intensity NN cord-016990-ot1wi3xi 508 16 in in IN cord-016990-ot1wi3xi 508 17 individual individual JJ cord-016990-ot1wi3xi 508 18 patients patient NNS cord-016990-ot1wi3xi 508 19 , , , cord-016990-ot1wi3xi 508 20 Viral viral JJ cord-016990-ot1wi3xi 508 21 inclusions inclusion NNS cord-016990-ot1wi3xi 508 22 can can MD cord-016990-ot1wi3xi 508 23 not not RB cord-016990-ot1wi3xi 508 24 be be VB cord-016990-ot1wi3xi 508 25 identified identify VBN cord-016990-ot1wi3xi 508 26 by by IN cord-016990-ot1wi3xi 508 27 light light JJ cord-016990-ot1wi3xi 508 28 microscopy microscopy NNS cord-016990-ot1wi3xi 508 29 ( ( -LRB- cord-016990-ot1wi3xi 508 30 Fig Fig NNP cord-016990-ot1wi3xi 508 31 , , , cord-016990-ot1wi3xi 508 32 _SP cord-016990-ot1wi3xi 508 33 11 11 CD cord-016990-ot1wi3xi 508 34 .8D .8D NNP cord-016990-ot1wi3xi 508 35 ) ) -RRB- cord-016990-ot1wi3xi 508 36 , , , cord-016990-ot1wi3xi 508 37 Secondary secondary JJ cord-016990-ot1wi3xi 508 38 bacterial bacterial JJ cord-016990-ot1wi3xi 508 39 infections infection NNS cord-016990-ot1wi3xi 508 40 with with IN cord-016990-ot1wi3xi 508 41 organisms organism NNS cord-016990-ot1wi3xi 508 42 such such JJ cord-016990-ot1wi3xi 508 43 as as IN cord-016990-ot1wi3xi 508 44 Streptococcus streptococcus NN cord-016990-ot1wi3xi 508 45 pneumoniae pneumoniae NN cord-016990-ot1wi3xi 508 46 ( ( -LRB- cord-016990-ot1wi3xi 508 47 group group NN cord-016990-ot1wi3xi 508 48 A a DT cord-016990-ot1wi3xi 508 49 streptococcus streptococcus NN cord-016990-ot1wi3xi 508 50 [ [ -LRB- cord-016990-ot1wi3xi 508 51 GAS gas NN cord-016990-ot1wi3xi 508 52 ] ] -RRB- cord-016990-ot1wi3xi 508 53 ) ) -RRB- cord-016990-ot1wi3xi 508 54 , , , cord-016990-ot1wi3xi 508 55 Staphylococcus Staphylococcus NNP cord-016990-ot1wi3xi 508 56 aureus aureus NN cord-016990-ot1wi3xi 508 57 , , , cord-016990-ot1wi3xi 508 58 and and CC cord-016990-ot1wi3xi 508 59 Haemophilus haemophilus JJ cord-016990-ot1wi3xi 508 60 influenzae influenzae NN cord-016990-ot1wi3xi 508 61 may may MD cord-016990-ot1wi3xi 508 62 occur occur VB cord-016990-ot1wi3xi 508 63 as as IN cord-016990-ot1wi3xi 508 64 a a DT cord-016990-ot1wi3xi 508 65 complication complication NN cord-016990-ot1wi3xi 508 66 in in IN cord-016990-ot1wi3xi 508 67 about about RB cord-016990-ot1wi3xi 508 68 50 50 CD cord-016990-ot1wi3xi 508 69 % % NN cord-016990-ot1wi3xi 508 70 to to TO cord-016990-ot1wi3xi 508 71 75 75 CD cord-016990-ot1wi3xi 508 72 % % NN cord-016990-ot1wi3xi 508 73 of of IN cord-016990-ot1wi3xi 508 74 fatal fatal JJ cord-016990-ot1wi3xi 508 75 cases case NNS cord-016990-ot1wi3xi 508 76 and and CC cord-016990-ot1wi3xi 508 77 make make VB cord-016990-ot1wi3xi 508 78 it -PRON- PRP cord-016990-ot1wi3xi 508 79 difficult difficult JJ cord-016990-ot1wi3xi 508 80 to to TO cord-016990-ot1wi3xi 508 81 recognize recognize VB cord-016990-ot1wi3xi 508 82 the the DT cord-016990-ot1wi3xi 508 83 pathologic pathologic JJ cord-016990-ot1wi3xi 508 84 changes change NNS cord-016990-ot1wi3xi 508 85 associated associate VBN cord-016990-ot1wi3xi 508 86 with with IN cord-016990-ot1wi3xi 508 87 the the DT cord-016990-ot1wi3xi 508 88 primary primary JJ cord-016990-ot1wi3xi 508 89 viral viral JJ cord-016990-ot1wi3xi 508 90 infec-445 infec-445 CD cord-016990-ot1wi3xi 508 91 tion tion NN cord-016990-ot1wi3xi 508 92 , , , cord-016990-ot1wi3xi 508 93 190,192,193 190,192,193 CD cord-016990-ot1wi3xi 508 94 The the DT cord-016990-ot1wi3xi 508 95 histopathologic histopathologic JJ cord-016990-ot1wi3xi 508 96 features feature NNS cord-016990-ot1wi3xi 508 97 in in IN cord-016990-ot1wi3xi 508 98 other other JJ cord-016990-ot1wi3xi 508 99 organs organ NNS cord-016990-ot1wi3xi 508 100 may may MD cord-016990-ot1wi3xi 508 101 include include VB cord-016990-ot1wi3xi 508 102 myocarditis myocarditis NN cord-016990-ot1wi3xi 508 103 , , , cord-016990-ot1wi3xi 508 104 cerebral cerebral JJ cord-016990-ot1wi3xi 508 105 edema edema NN cord-016990-ot1wi3xi 508 106 , , , cord-016990-ot1wi3xi 508 107 rhabdomyolysis rhabdomyolysis NN cord-016990-ot1wi3xi 508 108 , , , cord-016990-ot1wi3xi 508 109 and and CC cord-016990-ot1wi3xi 508 110 hemophagocytosis hemophagocytosis FW cord-016990-ot1wi3xi 508 111 ( ( -LRB- cord-016990-ot1wi3xi 508 112 Figs Figs NNP cord-016990-ot1wi3xi 508 113 , , , cord-016990-ot1wi3xi 508 114 11.8H 11.8h CD cord-016990-ot1wi3xi 508 115 and and CC cord-016990-ot1wi3xi 508 116 11.9E 11.9e CD cord-016990-ot1wi3xi 508 117 , , , cord-016990-ot1wi3xi 508 118 F F NNP cord-016990-ot1wi3xi 508 119 ) ) -RRB- cord-016990-ot1wi3xi 508 120 , , , cord-016990-ot1wi3xi 508 121 Immunohistochemistry Immunohistochemistry NNP cord-016990-ot1wi3xi 508 122 and and CC cord-016990-ot1wi3xi 508 123 ISH ISH NNP cord-016990-ot1wi3xi 508 124 assays assay NNS cord-016990-ot1wi3xi 508 125 demonstrate demonstrate VBP cord-016990-ot1wi3xi 508 126 that that IN cord-016990-ot1wi3xi 508 127 viral viral JJ cord-016990-ot1wi3xi 508 128 antigens antigen NNS cord-016990-ot1wi3xi 508 129 and and CC cord-016990-ot1wi3xi 508 130 nucleic nucleic JJ cord-016990-ot1wi3xi 508 131 acids acid NNS cord-016990-ot1wi3xi 508 132 are be VBP cord-016990-ot1wi3xi 508 133 usually usually RB cord-016990-ot1wi3xi 508 134 sparse sparse JJ cord-016990-ot1wi3xi 508 135 and and CC cord-016990-ot1wi3xi 508 136 are be VBP cord-016990-ot1wi3xi 508 137 primarily primarily RB cord-016990-ot1wi3xi 508 138 seen see VBN cord-016990-ot1wi3xi 508 139 in in IN cord-016990-ot1wi3xi 508 140 the the DT cord-016990-ot1wi3xi 508 141 bronchioepithelial bronchioepithelial JJ cord-016990-ot1wi3xi 508 142 cells cell NNS cord-016990-ot1wi3xi 508 143 of of IN cord-016990-ot1wi3xi 508 144 larger large JJR cord-016990-ot1wi3xi 508 145 bronchioles bronchiole NNS cord-016990-ot1wi3xi 508 146 ( ( -LRB- cord-016990-ot1wi3xi 508 147 Figs fig NNS cord-016990-ot1wi3xi 508 148 . . . cord-016990-ot1wi3xi 508 149 11.8C 11.8c CD cord-016990-ot1wi3xi 508 150 , , , cord-016990-ot1wi3xi 508 151 E E NNP cord-016990-ot1wi3xi 508 152 , , , cord-016990-ot1wi3xi 508 153 F F NNP cord-016990-ot1wi3xi 508 154 and and CC cord-016990-ot1wi3xi 508 155 11.9D 11.9d CD cord-016990-ot1wi3xi 508 156 ) ) -RRB- cord-016990-ot1wi3xi 508 157 . . . cord-016990-ot1wi3xi 509 1 105.189,190 105.189,190 CD cord-016990-ot1wi3xi 510 1 Antigens antigen NNS cord-016990-ot1wi3xi 510 2 are be VBP cord-016990-ot1wi3xi 510 3 more more RBR cord-016990-ot1wi3xi 510 4 readily readily RB cord-016990-ot1wi3xi 510 5 identified identify VBN cord-016990-ot1wi3xi 510 6 in in IN cord-016990-ot1wi3xi 510 7 patients patient NNS cord-016990-ot1wi3xi 510 8 who who WP cord-016990-ot1wi3xi 510 9 die die VBP cord-016990-ot1wi3xi 510 10 within within IN cord-016990-ot1wi3xi 510 11 3 3 CD cord-016990-ot1wi3xi 510 12 to to TO cord-016990-ot1wi3xi 510 13 4 4 CD cord-016990-ot1wi3xi 510 14 days day NNS cord-016990-ot1wi3xi 510 15 of of IN cord-016990-ot1wi3xi 510 16 onset onset NN cord-016990-ot1wi3xi 510 17 of of IN cord-016990-ot1wi3xi 510 18 illness illness NN cord-016990-ot1wi3xi 510 19 . . . cord-016990-ot1wi3xi 511 1 Recent recent JJ cord-016990-ot1wi3xi 511 2 studies study NNS cord-016990-ot1wi3xi 511 3 suggest suggest VBP cord-016990-ot1wi3xi 511 4 that that IN cord-016990-ot1wi3xi 511 5 unlike unlike IN cord-016990-ot1wi3xi 511 6 human human JJ cord-016990-ot1wi3xi 511 7 influenza influenza NN cord-016990-ot1wi3xi 511 8 viruses virus NNS cord-016990-ot1wi3xi 511 9 , , , cord-016990-ot1wi3xi 511 10 avian avian JJ cord-016990-ot1wi3xi 511 11 virus virus NN cord-016990-ot1wi3xi 511 12 H5N1 H5N1 NNP cord-016990-ot1wi3xi 511 13 preferentially preferentially RB cord-016990-ot1wi3xi 511 14 infects infect VBZ cord-016990-ot1wi3xi 511 15 cells cell NNS cord-016990-ot1wi3xi 511 16 in in IN cord-016990-ot1wi3xi 511 17 the the DT cord-016990-ot1wi3xi 511 18 lower low JJR cord-016990-ot1wi3xi 511 19 respiratory respiratory JJ cord-016990-ot1wi3xi 511 20 tract tract NN cord-016990-ot1wi3xi 511 21 of of IN cord-016990-ot1wi3xi 511 22 humans human NNS cord-016990-ot1wi3xi 511 23 , , , cord-016990-ot1wi3xi 511 24 resulting result VBG cord-016990-ot1wi3xi 511 25 in in IN cord-016990-ot1wi3xi 511 26 extensive extensive JJ cord-016990-ot1wi3xi 511 27 damage damage NN cord-016990-ot1wi3xi 511 28 of of IN cord-016990-ot1wi3xi 511 29 the the DT cord-016990-ot1wi3xi 511 30 lungs lung NNS cord-016990-ot1wi3xi 511 31 with with IN cord-016990-ot1wi3xi 511 32 minimal minimal JJ cord-016990-ot1wi3xi 511 33 pathology pathology NN cord-016990-ot1wi3xi 511 34 in in IN cord-016990-ot1wi3xi 511 35 the the DT cord-016990-ot1wi3xi 511 36 upper upper JJ cord-016990-ot1wi3xi 511 37 respiratory respiratory JJ cord-016990-ot1wi3xi 511 38 tract tract NN cord-016990-ot1wi3xi 511 39 ( ( -LRB- cord-016990-ot1wi3xi 511 40 Fig fig NN cord-016990-ot1wi3xi 511 41 . . . cord-016990-ot1wi3xi 512 1 11.10A 11.10A NNP cord-016990-ot1wi3xi 512 2 , , , cord-016990-ot1wi3xi 512 3 C C NNP cord-016990-ot1wi3xi 512 4 ) ) -RRB- cord-016990-ot1wi3xi 512 5 . . . cord-016990-ot1wi3xi 513 1 This this DT cord-016990-ot1wi3xi 513 2 may may MD cord-016990-ot1wi3xi 513 3 help help VB cord-016990-ot1wi3xi 513 4 explain explain VB cord-016990-ot1wi3xi 513 5 why why WRB cord-016990-ot1wi3xi 513 6 the the DT cord-016990-ot1wi3xi 513 7 H5N1 H5N1 NNP cord-016990-ot1wi3xi 513 8 avian avian JJ cord-016990-ot1wi3xi 513 9 influenza influenza NN cord-016990-ot1wi3xi 513 10 virus virus NN cord-016990-ot1wi3xi 513 11 is be VBZ cord-016990-ot1wi3xi 513 12 so so RB cord-016990-ot1wi3xi 513 13 lethal lethal JJ cord-016990-ot1wi3xi 513 14 to to IN cord-016990-ot1wi3xi 513 15 humans human NNS cord-016990-ot1wi3xi 513 16 but but CC cord-016990-ot1wi3xi 513 17 so so RB cord-016990-ot1wi3xi 513 18 difficult difficult JJ cord-016990-ot1wi3xi 513 19 to to TO cord-016990-ot1wi3xi 513 20 spread spread VB cord-016990-ot1wi3xi 513 21 from from IN cord-016990-ot1wi3xi 513 22 person person NN cord-016990-ot1wi3xi 513 23 to to IN cord-016990-ot1wi3xi 513 24 person person NN cord-016990-ot1wi3xi 513 25 . . . cord-016990-ot1wi3xi 514 1 These these DT cord-016990-ot1wi3xi 514 2 studies study NNS cord-016990-ot1wi3xi 514 3 show show VBP cord-016990-ot1wi3xi 514 4 that that IN cord-016990-ot1wi3xi 514 5 the the DT cord-016990-ot1wi3xi 514 6 avian avian JJ cord-016990-ot1wi3xi 514 7 virus virus NN cord-016990-ot1wi3xi 514 8 preferentially preferentially RB cord-016990-ot1wi3xi 514 9 binds bind VBZ cord-016990-ot1wi3xi 514 10 to to IN cord-016990-ot1wi3xi 514 11 the the DT cord-016990-ot1wi3xi 514 12 a-2,3-galactose a-2,3-galactose NNP cord-016990-ot1wi3xi 514 13 receptors receptor NNS cord-016990-ot1wi3xi 514 14 , , , cord-016990-ot1wi3xi 514 15 which which WDT cord-016990-ot1wi3xi 514 16 are be VBP cord-016990-ot1wi3xi 514 17 found find VBN cord-016990-ot1wi3xi 514 18 only only RB cord-016990-ot1wi3xi 514 19 in in IN cord-016990-ot1wi3xi 514 20 and and CC cord-016990-ot1wi3xi 514 21 around around IN cord-016990-ot1wi3xi 514 22 the the DT cord-016990-ot1wi3xi 514 23 alveoli alveolus NNS cord-016990-ot1wi3xi 514 24 . . . cord-016990-ot1wi3xi 515 1 This this DT cord-016990-ot1wi3xi 515 2 is be VBZ cord-016990-ot1wi3xi 515 3 in in IN cord-016990-ot1wi3xi 515 4 contrast contrast NN cord-016990-ot1wi3xi 515 5 to to IN cord-016990-ot1wi3xi 515 6 the the DT cord-016990-ot1wi3xi 515 7 human human JJ cord-016990-ot1wi3xi 515 8 Influenzaviruses Influenzaviruses NNPS cord-016990-ot1wi3xi 515 9 that that WDT cord-016990-ot1wi3xi 515 10 preferentially preferentially RB cord-016990-ot1wi3xi 515 11 bind bind VBP cord-016990-ot1wi3xi 515 12 to to IN cord-016990-ot1wi3xi 515 13 the the DT cord-016990-ot1wi3xi 515 14 a-2,6-receptors a-2,6-receptor NNS cord-016990-ot1wi3xi 515 15 , , , cord-016990-ot1wi3xi 515 16 which which WDT cord-016990-ot1wi3xi 515 17 are be VBP cord-016990-ot1wi3xi 515 18 found find VBN cord-016990-ot1wi3xi 515 19 throughout throughout IN cord-016990-ot1wi3xi 515 20 the the DT cord-016990-ot1wi3xi 515 21 respiratory respiratory JJ cord-016990-ot1wi3xi 515 22 tract tract NN cord-016990-ot1wi3xi 515 23 from from IN cord-016990-ot1wi3xi 515 24 the the DT cord-016990-ot1wi3xi 515 25 nose nose NN cord-016990-ot1wi3xi 515 26 to to IN cord-016990-ot1wi3xi 515 27 the the DT cord-016990-ot1wi3xi 515 28 lungs lung NNS cord-016990-ot1wi3xi 515 29 . . . cord-016990-ot1wi3xi 516 1 194.195 194.195 CD cord-016990-ot1wi3xi 517 1 In in IN cord-016990-ot1wi3xi 517 2 birds bird NNS cord-016990-ot1wi3xi 517 3 and and CC cord-016990-ot1wi3xi 517 4 other other JJ cord-016990-ot1wi3xi 517 5 animals animal NNS cord-016990-ot1wi3xi 517 6 , , , cord-016990-ot1wi3xi 517 7 viral viral JJ cord-016990-ot1wi3xi 517 8 antigens antigen NNS cord-016990-ot1wi3xi 517 9 can can MD cord-016990-ot1wi3xi 517 10 be be VB cord-016990-ot1wi3xi 517 11 detected detect VBN cord-016990-ot1wi3xi 517 12 in in IN cord-016990-ot1wi3xi 517 13 the the DT cord-016990-ot1wi3xi 517 14 lung lung NN cord-016990-ot1wi3xi 517 15 as as RB cord-016990-ot1wi3xi 517 16 well well RB cord-016990-ot1wi3xi 517 17 as as IN cord-016990-ot1wi3xi 517 18 a a DT cord-016990-ot1wi3xi 517 19 variety variety NN cord-016990-ot1wi3xi 517 20 of of IN cord-016990-ot1wi3xi 517 21 extrapulmonary extrapulmonary JJ cord-016990-ot1wi3xi 517 22 tissues tissue NNS cord-016990-ot1wi3xi 517 23 ( ( -LRB- cord-016990-ot1wi3xi 517 24 Fig Fig NNP cord-016990-ot1wi3xi 517 25 . . . cord-016990-ot1wi3xi 517 26 _SP cord-016990-ot1wi3xi 517 27 11.10B 11.10b CD cord-016990-ot1wi3xi 517 28 ) ) -RRB- cord-016990-ot1wi3xi 517 29 . . . cord-016990-ot1wi3xi 518 1 The the DT cord-016990-ot1wi3xi 518 2 diagnosis diagnosis NN cord-016990-ot1wi3xi 518 3 of of IN cord-016990-ot1wi3xi 518 4 influenza influenza NN cord-016990-ot1wi3xi 518 5 , , , cord-016990-ot1wi3xi 518 6 suspected suspect VBN cord-016990-ot1wi3xi 518 7 by by IN cord-016990-ot1wi3xi 518 8 history history NN cord-016990-ot1wi3xi 518 9 and and CC cord-016990-ot1wi3xi 518 10 clinical clinical JJ cord-016990-ot1wi3xi 518 11 manifestations manifestation NNS cord-016990-ot1wi3xi 518 12 , , , cord-016990-ot1wi3xi 518 13 can can MD cord-016990-ot1wi3xi 518 14 also also RB cord-016990-ot1wi3xi 518 15 be be VB cord-016990-ot1wi3xi 518 16 supported support VBN cord-016990-ot1wi3xi 518 17 histopathologically histopathologically RB cord-016990-ot1wi3xi 518 18 . . . cord-016990-ot1wi3xi 519 1 However however RB cord-016990-ot1wi3xi 519 2 , , , cord-016990-ot1wi3xi 519 3 because because IN cord-016990-ot1wi3xi 519 4 of of IN cord-016990-ot1wi3xi 519 5 the the DT cord-016990-ot1wi3xi 519 6 absence absence NN cord-016990-ot1wi3xi 519 7 of of IN cord-016990-ot1wi3xi 519 8 any any DT cord-016990-ot1wi3xi 519 9 characteristic characteristic JJ cord-016990-ot1wi3xi 519 10 viral viral JJ cord-016990-ot1wi3xi 519 11 inclusions inclusion NNS cord-016990-ot1wi3xi 519 12 and and CC cord-016990-ot1wi3xi 519 13 because because IN cord-016990-ot1wi3xi 519 14 the the DT cord-016990-ot1wi3xi 519 15 overall overall JJ cord-016990-ot1wi3xi 519 16 pathologic pathologic JJ cord-016990-ot1wi3xi 519 17 features feature NNS cord-016990-ot1wi3xi 519 18 of of IN cord-016990-ot1wi3xi 519 19 influenza influenza NN cord-016990-ot1wi3xi 519 20 may may MD cord-016990-ot1wi3xi 519 21 resemble resemble VB cord-016990-ot1wi3xi 519 22 other other JJ cord-016990-ot1wi3xi 519 23 viral viral JJ cord-016990-ot1wi3xi 519 24 , , , cord-016990-ot1wi3xi 519 25 rickettsial rickettsial JJ cord-016990-ot1wi3xi 519 26 , , , cord-016990-ot1wi3xi 519 27 and and CC cord-016990-ot1wi3xi 519 28 certain certain JJ cord-016990-ot1wi3xi 519 29 bacterial bacterial JJ cord-016990-ot1wi3xi 519 30 infections infection NNS cord-016990-ot1wi3xi 519 31 , , , cord-016990-ot1wi3xi 519 32 an an DT cord-016990-ot1wi3xi 519 33 unequivocal unequivocal JJ cord-016990-ot1wi3xi 519 34 diagnosis diagnosis NN cord-016990-ot1wi3xi 519 35 can can MD cord-016990-ot1wi3xi 519 36 be be VB cord-016990-ot1wi3xi 519 37 made make VBN cord-016990-ot1wi3xi 519 38 only only RB cord-016990-ot1wi3xi 519 39 by by IN cord-016990-ot1wi3xi 519 40 laboratory laboratory NN cord-016990-ot1wi3xi 519 41 tests test NNS cord-016990-ot1wi3xi 519 42 such such JJ cord-016990-ot1wi3xi 519 43 as as IN cord-016990-ot1wi3xi 519 44 viral viral JJ cord-016990-ot1wi3xi 519 45 culture culture NN cord-016990-ot1wi3xi 519 46 , , , cord-016990-ot1wi3xi 519 47 direct direct JJ cord-016990-ot1wi3xi 519 48 fluorescent fluorescent JJ cord-016990-ot1wi3xi 519 49 antibody antibody NN cord-016990-ot1wi3xi 519 50 and and CC cord-016990-ot1wi3xi 519 51 rapid rapid JJ cord-016990-ot1wi3xi 519 52 antigen antigen NN cord-016990-ot1wi3xi 519 53 assays assay NNS cord-016990-ot1wi3xi 519 54 , , , cord-016990-ot1wi3xi 519 55 serology serology NN cord-016990-ot1wi3xi 519 56 , , , cord-016990-ot1wi3xi 519 57 and and CC cord-016990-ot1wi3xi 519 58 IHC IHC NNP cord-016990-ot1wi3xi 519 59 . . . cord-016990-ot1wi3xi 520 1 190 190 CD cord-016990-ot1wi3xi 520 2 , , , cord-016990-ot1wi3xi 520 3 196,197 196,197 CD cord-016990-ot1wi3xi 520 4 Measles Measles NNP cord-016990-ot1wi3xi 520 5 Measles Measles NNP cord-016990-ot1wi3xi 520 6 ( ( -LRB- cord-016990-ot1wi3xi 520 7 rubeola rubeola NNP cord-016990-ot1wi3xi 520 8 ) ) -RRB- cord-016990-ot1wi3xi 520 9 is be VBZ cord-016990-ot1wi3xi 520 10 an an DT cord-016990-ot1wi3xi 520 11 infectious infectious JJ cord-016990-ot1wi3xi 520 12 , , , cord-016990-ot1wi3xi 520 13 acute acute JJ cord-016990-ot1wi3xi 520 14 febrile febrile JJ cord-016990-ot1wi3xi 520 15 viral viral JJ cord-016990-ot1wi3xi 520 16 illness illness NN cord-016990-ot1wi3xi 520 17 characterized characterize VBN cord-016990-ot1wi3xi 520 18 by by IN cord-016990-ot1wi3xi 520 19 upper upper JJ cord-016990-ot1wi3xi 520 20 respiratory respiratory JJ cord-016990-ot1wi3xi 520 21 tract tract NN cord-016990-ot1wi3xi 520 22 symptoms symptom NNS cord-016990-ot1wi3xi 520 23 , , , cord-016990-ot1wi3xi 520 24 fever fever NN cord-016990-ot1wi3xi 520 25 , , , cord-016990-ot1wi3xi 520 26 and and CC cord-016990-ot1wi3xi 520 27 a a DT cord-016990-ot1wi3xi 520 28 maculopapular maculopapular JJ cord-016990-ot1wi3xi 520 29 rash rash JJ cord-016990-ot1wi3xi 520 30 . . . cord-016990-ot1wi3xi 521 1 The the DT cord-016990-ot1wi3xi 521 2 causative causative JJ cord-016990-ot1wi3xi 521 3 agent agent NN cord-016990-ot1wi3xi 521 4 , , , cord-016990-ot1wi3xi 521 5 a a DT cord-016990-ot1wi3xi 521 6 member member NN cord-016990-ot1wi3xi 521 7 of of IN cord-016990-ot1wi3xi 521 8 the the DT cord-016990-ot1wi3xi 521 9 genus genus NN cord-016990-ot1wi3xi 521 10 Morbillivirus Morbillivirus NNP cord-016990-ot1wi3xi 521 11 , , , cord-016990-ot1wi3xi 521 12 of of IN cord-016990-ot1wi3xi 521 13 the the DT cord-016990-ot1wi3xi 521 14 family family NN cord-016990-ot1wi3xi 522 1 Paramyxoviridae,198,199 Paramyxoviridae,198,199 NNP cord-016990-ot1wi3xi 522 2 is be VBZ cord-016990-ot1wi3xi 522 3 an an DT cord-016990-ot1wi3xi 522 4 enveloped envelop VBN cord-016990-ot1wi3xi 522 5 virus virus NN cord-016990-ot1wi3xi 522 6 that that WDT cord-016990-ot1wi3xi 522 7 contains contain VBZ cord-016990-ot1wi3xi 522 8 a a DT cord-016990-ot1wi3xi 522 9 negative negative JJ cord-016990-ot1wi3xi 522 10 sense sense NN cord-016990-ot1wi3xi 522 11 , , , cord-016990-ot1wi3xi 522 12 single single RB cord-016990-ot1wi3xi 522 13 - - HYPH cord-016990-ot1wi3xi 522 14 stranded strand VBN cord-016990-ot1wi3xi 522 15 RNA RNA NNP cord-016990-ot1wi3xi 522 16 genome genome NN cord-016990-ot1wi3xi 522 17 of of IN cord-016990-ot1wi3xi 522 18 16,000 16,000 CD cord-016990-ot1wi3xi 522 19 nucleotides nucleotide NNS cord-016990-ot1wi3xi 522 20 . . . cord-016990-ot1wi3xi 523 1 Other other JJ cord-016990-ot1wi3xi 523 2 human human JJ cord-016990-ot1wi3xi 523 3 pathogens pathogen NNS cord-016990-ot1wi3xi 523 4 in in IN cord-016990-ot1wi3xi 523 5 this this DT cord-016990-ot1wi3xi 523 6 family family NN cord-016990-ot1wi3xi 523 7 include include VBP cord-016990-ot1wi3xi 523 8 parainfluenza parainfluenza NNP cord-016990-ot1wi3xi 523 9 , , , cord-016990-ot1wi3xi 523 10 mumps mumps NN cord-016990-ot1wi3xi 523 11 , , , cord-016990-ot1wi3xi 523 12 and and CC cord-016990-ot1wi3xi 523 13 respiratory respiratory JJ cord-016990-ot1wi3xi 523 14 syncytial syncytial JJ cord-016990-ot1wi3xi 523 15 viruses virus NNS cord-016990-ot1wi3xi 523 16 . . . cord-016990-ot1wi3xi 524 1 Measles measles NN cord-016990-ot1wi3xi 524 2 virions virion NNS cord-016990-ot1wi3xi 524 3 are be VBP cord-016990-ot1wi3xi 524 4 pleomorphic pleomorphic JJ cord-016990-ot1wi3xi 524 5 , , , cord-016990-ot1wi3xi 524 6 generally generally RB cord-016990-ot1wi3xi 524 7 spherical spherical JJ cord-016990-ot1wi3xi 524 8 , , , cord-016990-ot1wi3xi 524 9 enveloped envelop VBD cord-016990-ot1wi3xi 524 10 particles particle NNS cord-016990-ot1wi3xi 524 11 from from IN cord-016990-ot1wi3xi 524 12 120 120 CD cord-016990-ot1wi3xi 524 13 to to TO cord-016990-ot1wi3xi 524 14 250 250 CD cord-016990-ot1wi3xi 524 15 nm nm NN cord-016990-ot1wi3xi 524 16 in in IN cord-016990-ot1wi3xi 524 17 diameter diameter NN cord-016990-ot1wi3xi 524 18 . . . cord-016990-ot1wi3xi 525 1 The the DT cord-016990-ot1wi3xi 525 2 virus virus NN cord-016990-ot1wi3xi 525 3 is be VBZ cord-016990-ot1wi3xi 525 4 morphologically morphologically RB cord-016990-ot1wi3xi 525 5 indistinguishable indistinguishable JJ cord-016990-ot1wi3xi 525 6 from from IN cord-016990-ot1wi3xi 525 7 other other JJ cord-016990-ot1wi3xi 525 8 members member NNS cord-016990-ot1wi3xi 525 9 of of IN cord-016990-ot1wi3xi 525 10 the the DT cord-016990-ot1wi3xi 525 11 Paramyxoviridae Paramyxoviridae NNP cord-016990-ot1wi3xi 525 12 family family NN cord-016990-ot1wi3xi 525 13 when when WRB cord-016990-ot1wi3xi 525 14 viewed view VBN cord-016990-ot1wi3xi 525 15 by by IN cord-016990-ot1wi3xi 525 16 negative negative JJ cord-016990-ot1wi3xi 525 17 contrast contrast NN cord-016990-ot1wi3xi 525 18 electron electron NN cord-016990-ot1wi3xi 525 19 microscopy microscopy NN cord-016990-ot1wi3xi 525 20 . . . cord-016990-ot1wi3xi 526 1 A a DT cord-016990-ot1wi3xi 526 2 lipid lipid NN cord-016990-ot1wi3xi 526 3 envelope envelope NN cord-016990-ot1wi3xi 526 4 surrounds surround VBZ cord-016990-ot1wi3xi 526 5 a a DT cord-016990-ot1wi3xi 526 6 helical helical JJ cord-016990-ot1wi3xi 526 7 nucleocapsid nucleocapsid NN cord-016990-ot1wi3xi 526 8 composed compose VBN cord-016990-ot1wi3xi 526 9 of of IN cord-016990-ot1wi3xi 526 10 RNA RNA NNP cord-016990-ot1wi3xi 526 11 and and CC cord-016990-ot1wi3xi 526 12 protein protein NN cord-016990-ot1wi3xi 526 13 . . . cord-016990-ot1wi3xi 527 1 Two two CD cord-016990-ot1wi3xi 527 2 transmembrane transmembrane NN cord-016990-ot1wi3xi 527 3 glycoproteins glycoprotein NNS cord-016990-ot1wi3xi 527 4 , , , cord-016990-ot1wi3xi 527 5 hemagglutinin hemagglutinin NN cord-016990-ot1wi3xi 527 6 ( ( -LRB- cord-016990-ot1wi3xi 527 7 H H NNP cord-016990-ot1wi3xi 527 8 ) ) -RRB- cord-016990-ot1wi3xi 527 9 and and CC cord-016990-ot1wi3xi 527 10 fusion fusion NN cord-016990-ot1wi3xi 527 11 ( ( -LRB- cord-016990-ot1wi3xi 527 12 F F NNP cord-016990-ot1wi3xi 527 13 ) ) -RRB- cord-016990-ot1wi3xi 527 14 , , , cord-016990-ot1wi3xi 527 15 are be VBP cord-016990-ot1wi3xi 527 16 present present JJ cord-016990-ot1wi3xi 527 17 in in IN cord-016990-ot1wi3xi 527 18 the the DT cord-016990-ot1wi3xi 527 19 envelope envelope NN cord-016990-ot1wi3xi 527 20 and and CC cord-016990-ot1wi3xi 527 21 appear appear VBP cord-016990-ot1wi3xi 527 22 as as IN cord-016990-ot1wi3xi 527 23 surface surface NN cord-016990-ot1wi3xi 527 24 projections projection NNS cord-016990-ot1wi3xi 527 25 . . . cord-016990-ot1wi3xi 528 1 These these DT cord-016990-ot1wi3xi 528 2 proteins protein NNS cord-016990-ot1wi3xi 528 3 mediate mediate VBP cord-016990-ot1wi3xi 528 4 viral viral JJ cord-016990-ot1wi3xi 528 5 attachment attachment NN cord-016990-ot1wi3xi 528 6 and and CC cord-016990-ot1wi3xi 528 7 FIGURE figure NN cord-016990-ot1wi3xi 528 8 11.8 11.8 CD cord-016990-ot1wi3xi 528 9 . . . cord-016990-ot1wi3xi 529 1 Influenza influenza NN cord-016990-ot1wi3xi 529 2 A. a. NN cord-016990-ot1wi3xi 529 3 A. a. NN cord-016990-ot1wi3xi 529 4 Alveolar alveolar NN cord-016990-ot1wi3xi 529 5 damage damage NN cord-016990-ot1wi3xi 529 6 in in IN cord-016990-ot1wi3xi 529 7 a a DT cord-016990-ot1wi3xi 529 8 patient patient NN cord-016990-ot1wi3xi 529 9 with with IN cord-016990-ot1wi3xi 529 10 fatal fatal JJ cord-016990-ot1wi3xi 529 11 influenza influenza NN cord-016990-ot1wi3xi 529 12 A a DT cord-016990-ot1wi3xi 529 13 showing show VBG cord-016990-ot1wi3xi 529 14 prominent prominent JJ cord-016990-ot1wi3xi 529 15 congestion congestion NN cord-016990-ot1wi3xi 529 16 with with IN cord-016990-ot1wi3xi 529 17 intraalveolar intraalveolar NNP cord-016990-ot1wi3xi 529 18 macrophages macrophage NNS cord-016990-ot1wi3xi 529 19 and and CC cord-016990-ot1wi3xi 529 20 fibrin fibrin NN cord-016990-ot1wi3xi 529 21 deposits deposit NNS cord-016990-ot1wi3xi 529 22 . . . cord-016990-ot1wi3xi 530 1 B. B. NNP cord-016990-ot1wi3xi 530 2 Extensive extensive JJ cord-016990-ot1wi3xi 530 3 ulceration ulceration NN cord-016990-ot1wi3xi 530 4 of of IN cord-016990-ot1wi3xi 530 5 respiratory respiratory JJ cord-016990-ot1wi3xi 530 6 epithelium epithelium NN cord-016990-ot1wi3xi 530 7 in in IN cord-016990-ot1wi3xi 530 8 a a DT cord-016990-ot1wi3xi 530 9 large large JJ cord-016990-ot1wi3xi 530 10 airway airway NN cord-016990-ot1wi3xi 530 11 of of IN cord-016990-ot1wi3xi 530 12 a a DT cord-016990-ot1wi3xi 530 13 patient patient NN cord-016990-ot1wi3xi 530 14 with with IN cord-016990-ot1wi3xi 530 15 fatal fatal JJ cord-016990-ot1wi3xi 530 16 influenza influenza NN cord-016990-ot1wi3xi 530 17 A. a. NN cord-016990-ot1wi3xi 531 1 The the DT cord-016990-ot1wi3xi 531 2 lamina lamina JJ cord-016990-ot1wi3xi 531 3 propria propria NN cord-016990-ot1wi3xi 531 4 shows show VBZ cord-016990-ot1wi3xi 531 5 florid florid JJ cord-016990-ot1wi3xi 531 6 vascular vascular JJ cord-016990-ot1wi3xi 531 7 congestion congestion NN cord-016990-ot1wi3xi 531 8 and and CC cord-016990-ot1wi3xi 531 9 focal focal JJ cord-016990-ot1wi3xi 531 10 hemorrhage hemorrhage NN cord-016990-ot1wi3xi 531 11 , , , cord-016990-ot1wi3xi 531 12 and and CC cord-016990-ot1wi3xi 531 13 predominantly predominantly RB cord-016990-ot1wi3xi 531 14 mononuclear mononuclear JJ cord-016990-ot1wi3xi 531 15 inflammatory inflammatory JJ cord-016990-ot1wi3xi 531 16 cell cell NN cord-016990-ot1wi3xi 531 17 infiltrates infiltrate VBZ cord-016990-ot1wi3xi 531 18 . . . cord-016990-ot1wi3xi 532 1 C C NNP cord-016990-ot1wi3xi 532 2 - - HYPH cord-016990-ot1wi3xi 532 3 E. E. NNP cord-016990-ot1wi3xi 532 4 Immunohistochemical Immunohistochemical NNP cord-016990-ot1wi3xi 532 5 staining stain VBG cord-016990-ot1wi3xi 532 6 ( ( -LRB- cord-016990-ot1wi3xi 532 7 C C NNP cord-016990-ot1wi3xi 532 8 , , , cord-016990-ot1wi3xi 532 9 E E NNP cord-016990-ot1wi3xi 532 10 ) ) -RRB- cord-016990-ot1wi3xi 532 11 of of IN cord-016990-ot1wi3xi 532 12 influenza influenza NN cord-016990-ot1wi3xi 532 13 virus virus NN cord-016990-ot1wi3xi 533 1 A a DT cord-016990-ot1wi3xi 533 2 hemagglutinin hemagglutinin NN cord-016990-ot1wi3xi 533 3 antigens antigen NNS cord-016990-ot1wi3xi 533 4 in in IN cord-016990-ot1wi3xi 533 5 the the DT cord-016990-ot1wi3xi 533 6 cytoplasm cytoplasm NN cord-016990-ot1wi3xi 533 7 of of IN cord-016990-ot1wi3xi 533 8 residual residual JJ cord-016990-ot1wi3xi 533 9 respiratory respiratory JJ cord-016990-ot1wi3xi 533 10 epithelial epithelial JJ cord-016990-ot1wi3xi 533 11 cells cell NNS cord-016990-ot1wi3xi 533 12 of of IN cord-016990-ot1wi3xi 533 13 a a DT cord-016990-ot1wi3xi 533 14 large large JJ cord-016990-ot1wi3xi 533 15 airway airway NN cord-016990-ot1wi3xi 533 16 . . . cord-016990-ot1wi3xi 534 1 This this DT cord-016990-ot1wi3xi 534 2 same same JJ cord-016990-ot1wi3xi 534 3 focus focus NN cord-016990-ot1wi3xi 534 4 of of IN cord-016990-ot1wi3xi 534 5 extensively extensively RB cord-016990-ot1wi3xi 534 6 infected infect VBN cord-016990-ot1wi3xi 534 7 respiratory respiratory JJ cord-016990-ot1wi3xi 534 8 epithelium epithelium NN cord-016990-ot1wi3xi 534 9 ( ( -LRB- cord-016990-ot1wi3xi 534 10 D d NN cord-016990-ot1wi3xi 534 11 ) ) -RRB- cord-016990-ot1wi3xi 534 12 demonstrates demonstrate VBZ cord-016990-ot1wi3xi 534 13 that that IN cord-016990-ot1wi3xi 534 14 , , , cord-016990-ot1wi3xi 534 15 unlike unlike IN cord-016990-ot1wi3xi 534 16 many many JJ cord-016990-ot1wi3xi 534 17 other other JJ cord-016990-ot1wi3xi 534 18 viral viral JJ cord-016990-ot1wi3xi 534 19 respiratory respiratory JJ cord-016990-ot1wi3xi 534 20 pathogens pathogen NNS cord-016990-ot1wi3xi 534 21 , , , cord-016990-ot1wi3xi 534 22 influenza influenza NN cord-016990-ot1wi3xi 534 23 viruses virus NNS cord-016990-ot1wi3xi 534 24 do do VBP cord-016990-ot1wi3xi 534 25 not not RB cord-016990-ot1wi3xi 534 26 elicit elicit VB cord-016990-ot1wi3xi 534 27 specific specific JJ cord-016990-ot1wi3xi 534 28 cytopathic cytopathic JJ cord-016990-ot1wi3xi 534 29 effects effect NNS cord-016990-ot1wi3xi 534 30 in in IN cord-016990-ot1wi3xi 534 31 infected infected JJ cord-016990-ot1wi3xi 534 32 cells cell NNS cord-016990-ot1wi3xi 534 33 . . . cord-016990-ot1wi3xi 535 1 F. F. NNP cord-016990-ot1wi3xi 535 2 In in IN cord-016990-ot1wi3xi 535 3 - - HYPH cord-016990-ot1wi3xi 535 4 situ situ NN cord-016990-ot1wi3xi 535 5 hybridization hybridization NN cord-016990-ot1wi3xi 535 6 assay assay NN cord-016990-ot1wi3xi 535 7 demon-• demon-• CD cord-016990-ot1wi3xi 535 8 fusion fusion NN cord-016990-ot1wi3xi 535 9 with with IN cord-016990-ot1wi3xi 535 10 respiratory respiratory JJ cord-016990-ot1wi3xi 535 11 epithelium epithelium NN cord-016990-ot1wi3xi 535 12 . . . cord-016990-ot1wi3xi 536 1 They -PRON- PRP cord-016990-ot1wi3xi 536 2 are be VBP cord-016990-ot1wi3xi 536 3 also also RB cord-016990-ot1wi3xi 536 4 believed believe VBN cord-016990-ot1wi3xi 536 5 to to IN cord-016990-ot1wi3xi 536 6 playa playa NNP cord-016990-ot1wi3xi 536 7 role role NN cord-016990-ot1wi3xi 536 8 in in IN cord-016990-ot1wi3xi 536 9 virus virus NN cord-016990-ot1wi3xi 536 10 maturation maturation NN cord-016990-ot1wi3xi 536 11 through through IN cord-016990-ot1wi3xi 536 12 their -PRON- PRP$ cord-016990-ot1wi3xi 536 13 interaction interaction NN cord-016990-ot1wi3xi 536 14 with with IN cord-016990-ot1wi3xi 536 15 the the DT cord-016990-ot1wi3xi 536 16 matrix matrix NN cord-016990-ot1wi3xi 536 17 ( ( -LRB- cord-016990-ot1wi3xi 536 18 M M NNP cord-016990-ot1wi3xi 536 19 ) ) -RRB- cord-016990-ot1wi3xi 536 20 protein protein NN cord-016990-ot1wi3xi 536 21 , , , cord-016990-ot1wi3xi 536 22 which which WDT cord-016990-ot1wi3xi 536 23 , , , cord-016990-ot1wi3xi 536 24 in in IN cord-016990-ot1wi3xi 536 25 turn turn NN cord-016990-ot1wi3xi 536 26 , , , cord-016990-ot1wi3xi 536 27 is be VBZ cord-016990-ot1wi3xi 536 28 thought think VBN cord-016990-ot1wi3xi 536 29 to to TO cord-016990-ot1wi3xi 536 30 interact interact VB cord-016990-ot1wi3xi 536 31 with with IN cord-016990-ot1wi3xi 536 32 the the DT cord-016990-ot1wi3xi 536 33 nucleocapsid nucleocapsid NNP cord-016990-ot1wi3xi 536 34 structure structure NN cord-016990-ot1wi3xi 536 35 . . . cord-016990-ot1wi3xi 537 1 2OO 2oo CD cord-016990-ot1wi3xi 537 2 Measles Measles NNP cord-016990-ot1wi3xi 537 3 is be VBZ cord-016990-ot1wi3xi 537 4 a a DT cord-016990-ot1wi3xi 537 5 highly highly RB cord-016990-ot1wi3xi 537 6 communicable communicable JJ cord-016990-ot1wi3xi 537 7 disease disease NN cord-016990-ot1wi3xi 537 8 of of IN cord-016990-ot1wi3xi 537 9 worldwide worldwide JJ cord-016990-ot1wi3xi 537 10 distribution distribution NN cord-016990-ot1wi3xi 537 11 . . . cord-016990-ot1wi3xi 538 1 Before before IN cord-016990-ot1wi3xi 538 2 the the DT cord-016990-ot1wi3xi 538 3 introduction introduction NN cord-016990-ot1wi3xi 538 4 of of IN cord-016990-ot1wi3xi 538 5 measles measle NNS cord-016990-ot1wi3xi 538 6 vaccines vaccine NNS cord-016990-ot1wi3xi 538 7 , , , cord-016990-ot1wi3xi 538 8 epidemics epidemic NNS cord-016990-ot1wi3xi 538 9 occurred occur VBD cord-016990-ot1wi3xi 538 10 about about RB cord-016990-ot1wi3xi 538 11 every every DT cord-016990-ot1wi3xi 538 12 2 2 CD cord-016990-ot1wi3xi 538 13 to to TO cord-016990-ot1wi3xi 538 14 5 5 CD cord-016990-ot1wi3xi 538 15 years year NNS cord-016990-ot1wi3xi 538 16 when when WRB cord-016990-ot1wi3xi 538 17 the the DT cord-016990-ot1wi3xi 538 18 percentage percentage NN cord-016990-ot1wi3xi 538 19 of of IN cord-016990-ot1wi3xi 538 20 nonimmune nonimmune JJ cord-016990-ot1wi3xi 538 21 members member NNS cord-016990-ot1wi3xi 538 22 of of IN cord-016990-ot1wi3xi 538 23 a a DT cord-016990-ot1wi3xi 538 24 population population NN cord-016990-ot1wi3xi 538 25 reached reach VBD cord-016990-ot1wi3xi 538 26 critical critical JJ cord-016990-ot1wi3xi 538 27 levels level NNS cord-016990-ot1wi3xi 538 28 . . . cord-016990-ot1wi3xi 539 1 Recently recently RB cord-016990-ot1wi3xi 539 2 , , , cord-016990-ot1wi3xi 539 3 epidemics epidemic NNS cord-016990-ot1wi3xi 539 4 have have VBP cord-016990-ot1wi3xi 539 5 occurred occur VBN cord-016990-ot1wi3xi 539 6 in in IN cord-016990-ot1wi3xi 539 7 cycles cycle NNS cord-016990-ot1wi3xi 539 8 of of IN cord-016990-ot1wi3xi 539 9 about about IN cord-016990-ot1wi3xi 539 10 10 10 CD cord-016990-ot1wi3xi 539 11 years year NNS cord-016990-ot1wi3xi 539 12 . . . cord-016990-ot1wi3xi 540 1 In in IN cord-016990-ot1wi3xi 540 2 small small JJ cord-016990-ot1wi3xi 540 3 and and CC cord-016990-ot1wi3xi 540 4 isolated isolated JJ cord-016990-ot1wi3xi 540 5 communities community NNS cord-016990-ot1wi3xi 540 6 , , , cord-016990-ot1wi3xi 540 7 measles measle NNS cord-016990-ot1wi3xi 540 8 circulation circulation NN cord-016990-ot1wi3xi 540 9 may may MD cord-016990-ot1wi3xi 540 10 cease cease VB cord-016990-ot1wi3xi 540 11 altogether altogether RB cord-016990-ot1wi3xi 540 12 unless unless IN cord-016990-ot1wi3xi 540 13 it -PRON- PRP cord-016990-ot1wi3xi 540 14 is be VBZ cord-016990-ot1wi3xi 540 15 reintroduced reintroduce VBN cord-016990-ot1wi3xi 540 16 . . . cord-016990-ot1wi3xi 541 1 If if IN cord-016990-ot1wi3xi 541 2 introduced introduce VBN cord-016990-ot1wi3xi 541 3 in in IN cord-016990-ot1wi3xi 541 4 non non JJ cord-016990-ot1wi3xi 541 5 immune immune JJ cord-016990-ot1wi3xi 541 6 populations population NNS cord-016990-ot1wi3xi 541 7 , , , cord-016990-ot1wi3xi 541 8 the the DT cord-016990-ot1wi3xi 541 9 disease disease NN cord-016990-ot1wi3xi 541 10 tends tend VBZ cord-016990-ot1wi3xi 541 11 to to TO cord-016990-ot1wi3xi 541 12 be be VB cord-016990-ot1wi3xi 541 13 more more RBR cord-016990-ot1wi3xi 541 14 severe severe JJ cord-016990-ot1wi3xi 541 15 and and CC cord-016990-ot1wi3xi 541 16 may may MD cord-016990-ot1wi3xi 541 17 involve involve VB cord-016990-ot1wi3xi 541 18 more more JJR cord-016990-ot1wi3xi 541 19 than than IN cord-016990-ot1wi3xi 541 20 90 90 CD cord-016990-ot1wi3xi 541 21 % % NN cord-016990-ot1wi3xi 541 22 of of IN cord-016990-ot1wi3xi 541 23 the the DT cord-016990-ot1wi3xi 541 24 population population NN cord-016990-ot1wi3xi 541 25 because because IN cord-016990-ot1wi3xi 541 26 of of IN cord-016990-ot1wi3xi 541 27 the the DT cord-016990-ot1wi3xi 541 28 highly highly RB cord-016990-ot1wi3xi 541 29 infectious infectious JJ cord-016990-ot1wi3xi 541 30 nature nature NN cord-016990-ot1wi3xi 541 31 of of IN cord-016990-ot1wi3xi 541 32 the the DT cord-016990-ot1wi3xi 541 33 virus virus NN cord-016990-ot1wi3xi 541 34 . . . cord-016990-ot1wi3xi 542 1 Although although IN cord-016990-ot1wi3xi 542 2 still still RB cord-016990-ot1wi3xi 542 3 a a DT cord-016990-ot1wi3xi 542 4 significant significant JJ cord-016990-ot1wi3xi 542 5 problem problem NN cord-016990-ot1wi3xi 542 6 in in IN cord-016990-ot1wi3xi 542 7 underdeveloped underdeveloped JJ cord-016990-ot1wi3xi 542 8 countries country NNS cord-016990-ot1wi3xi 542 9 , , , cord-016990-ot1wi3xi 542 10 measles measle NNS cord-016990-ot1wi3xi 542 11 infection infection NN cord-016990-ot1wi3xi 542 12 became become VBD cord-016990-ot1wi3xi 542 13 uncommon uncommon JJ cord-016990-ot1wi3xi 542 14 in in IN cord-016990-ot1wi3xi 542 15 the the DT cord-016990-ot1wi3xi 542 16 US US NNP cord-016990-ot1wi3xi 542 17 . . . cord-016990-ot1wi3xi 543 1 after after IN cord-016990-ot1wi3xi 543 2 the the DT cord-016990-ot1wi3xi 543 3 development development NN cord-016990-ot1wi3xi 543 4 and and CC cord-016990-ot1wi3xi 543 5 widespread widespread JJ cord-016990-ot1wi3xi 543 6 use use NN cord-016990-ot1wi3xi 543 7 of of IN cord-016990-ot1wi3xi 543 8 an an DT cord-016990-ot1wi3xi 543 9 effective effective JJ cord-016990-ot1wi3xi 543 10 measles measle NNS cord-016990-ot1wi3xi 543 11 vaccine vaccine NN cord-016990-ot1wi3xi 543 12 . . . cord-016990-ot1wi3xi 544 1 However however RB cord-016990-ot1wi3xi 544 2 , , , cord-016990-ot1wi3xi 544 3 a a DT cord-016990-ot1wi3xi 544 4 recrudescence recrudescence NN cord-016990-ot1wi3xi 544 5 of of IN cord-016990-ot1wi3xi 544 6 measles measle NNS cord-016990-ot1wi3xi 544 7 infection infection NN cord-016990-ot1wi3xi 544 8 occurred occur VBD cord-016990-ot1wi3xi 544 9 in in IN cord-016990-ot1wi3xi 544 10 several several JJ cord-016990-ot1wi3xi 544 11 large large JJ cord-016990-ot1wi3xi 544 12 US US NNP cord-016990-ot1wi3xi 544 13 . . . cord-016990-ot1wi3xi 545 1 urban urban JJ cord-016990-ot1wi3xi 545 2 centers center NNS cord-016990-ot1wi3xi 545 3 in in IN cord-016990-ot1wi3xi 545 4 recent recent JJ cord-016990-ot1wi3xi 545 5 years year NNS cord-016990-ot1wi3xi 545 6 , , , cord-016990-ot1wi3xi 545 7 associated associate VBN cord-016990-ot1wi3xi 545 8 with with IN cord-016990-ot1wi3xi 545 9 reduced reduce VBN cord-016990-ot1wi3xi 545 10 use use NN cord-016990-ot1wi3xi 545 11 of of IN cord-016990-ot1wi3xi 545 12 the the DT cord-016990-ot1wi3xi 545 13 vaccine vaccine NN cord-016990-ot1wi3xi 545 14 among among IN cord-016990-ot1wi3xi 545 15 children child NNS cord-016990-ot1wi3xi 545 16 and and CC cord-016990-ot1wi3xi 545 17 young young JJ cord-016990-ot1wi3xi 545 18 adults adult NNS cord-016990-ot1wi3xi 545 19 . . . cord-016990-ot1wi3xi 546 1 During during IN cord-016990-ot1wi3xi 546 2 the the DT cord-016990-ot1wi3xi 546 3 peak peak NN cord-016990-ot1wi3xi 546 4 of of IN cord-016990-ot1wi3xi 546 5 this this DT cord-016990-ot1wi3xi 546 6 activity activity NN cord-016990-ot1wi3xi 546 7 ( ( -LRB- cord-016990-ot1wi3xi 546 8 i.e. i.e. FW cord-016990-ot1wi3xi 546 9 , , , cord-016990-ot1wi3xi 546 10 between between IN cord-016990-ot1wi3xi 546 11 1989 1989 CD cord-016990-ot1wi3xi 546 12 and and CC cord-016990-ot1wi3xi 546 13 1991 1991 CD cord-016990-ot1wi3xi 546 14 ) ) -RRB- cord-016990-ot1wi3xi 546 15 , , , cord-016990-ot1wi3xi 546 16 greater great JJR cord-016990-ot1wi3xi 546 17 than than IN cord-016990-ot1wi3xi 546 18 50,000 50,000 CD cord-016990-ot1wi3xi 546 19 measles measles NN cord-016990-ot1wi3xi 546 20 cases case NNS cord-016990-ot1wi3xi 546 21 and and CC cord-016990-ot1wi3xi 546 22 approximately approximately RB cord-016990-ot1wi3xi 546 23 150 150 CD cord-016990-ot1wi3xi 546 24 measlesassociated measlesassociate VBN cord-016990-ot1wi3xi 546 25 deaths death NNS cord-016990-ot1wi3xi 546 26 were be VBD cord-016990-ot1wi3xi 546 27 reported report VBN cord-016990-ot1wi3xi 546 28 . . . cord-016990-ot1wi3xi 547 1 20l 20l NNP cord-016990-ot1wi3xi 547 2 Measles Measles NNP cord-016990-ot1wi3xi 547 3 virus virus NN cord-016990-ot1wi3xi 547 4 is be VBZ cord-016990-ot1wi3xi 547 5 highly highly RB cord-016990-ot1wi3xi 547 6 contagious contagious JJ cord-016990-ot1wi3xi 547 7 , , , cord-016990-ot1wi3xi 547 8 spread spread VBN cord-016990-ot1wi3xi 547 9 by by IN cord-016990-ot1wi3xi 547 10 aerosols aerosol NNS cord-016990-ot1wi3xi 547 11 and and CC cord-016990-ot1wi3xi 547 12 droplets droplet NNS cord-016990-ot1wi3xi 547 13 from from IN cord-016990-ot1wi3xi 547 14 respiratory respiratory JJ cord-016990-ot1wi3xi 547 15 secretions secretion NNS cord-016990-ot1wi3xi 547 16 of of IN cord-016990-ot1wi3xi 547 17 acute acute JJ cord-016990-ot1wi3xi 547 18 cases.202 cases.202 NNS cord-016990-ot1wi3xi 547 19 - - : cord-016990-ot1wi3xi 547 20 204 204 CD cord-016990-ot1wi3xi 547 21 Less less RBR cord-016990-ot1wi3xi 547 22 frequently frequently RB cord-016990-ot1wi3xi 547 23 , , , cord-016990-ot1wi3xi 547 24 contaminated contaminated JJ cord-016990-ot1wi3xi 547 25 fomites fomite NNS cord-016990-ot1wi3xi 547 26 are be VBP cord-016990-ot1wi3xi 547 27 involved involve VBN cord-016990-ot1wi3xi 547 28 in in IN cord-016990-ot1wi3xi 547 29 transmission transmission NN cord-016990-ot1wi3xi 547 30 . . . cord-016990-ot1wi3xi 548 1 A a DT cord-016990-ot1wi3xi 548 2 person person NN cord-016990-ot1wi3xi 548 3 with with IN cord-016990-ot1wi3xi 548 4 acute acute JJ cord-016990-ot1wi3xi 548 5 measles measle NNS cord-016990-ot1wi3xi 548 6 is be VBZ cord-016990-ot1wi3xi 548 7 infective infective JJ cord-016990-ot1wi3xi 548 8 from from IN cord-016990-ot1wi3xi 548 9 just just RB cord-016990-ot1wi3xi 548 10 before before IN cord-016990-ot1wi3xi 548 11 onset onset NN cord-016990-ot1wi3xi 548 12 of of IN cord-016990-ot1wi3xi 548 13 symptoms symptom NNS cord-016990-ot1wi3xi 548 14 to to IN cord-016990-ot1wi3xi 548 15 defervescence defervescence NN cord-016990-ot1wi3xi 548 16 of of IN cord-016990-ot1wi3xi 548 17 fever fever NN cord-016990-ot1wi3xi 548 18 . . . cord-016990-ot1wi3xi 549 1 In in IN cord-016990-ot1wi3xi 549 2 developed develop VBN cord-016990-ot1wi3xi 549 3 countries country NNS cord-016990-ot1wi3xi 549 4 , , , cord-016990-ot1wi3xi 549 5 likely likely JJ cord-016990-ot1wi3xi 549 6 settings setting NNS cord-016990-ot1wi3xi 549 7 for for IN cord-016990-ot1wi3xi 549 8 exposure exposure NN cord-016990-ot1wi3xi 549 9 to to IN cord-016990-ot1wi3xi 549 10 measles measle NNS cord-016990-ot1wi3xi 549 11 virus virus NN cord-016990-ot1wi3xi 549 12 are be VBP cord-016990-ot1wi3xi 549 13 infectious infectious JJ cord-016990-ot1wi3xi 549 14 disease disease NN cord-016990-ot1wi3xi 549 15 clinics clinic NNS cord-016990-ot1wi3xi 549 16 , , , cord-016990-ot1wi3xi 549 17 pediatric pediatric JJ cord-016990-ot1wi3xi 549 18 emergency emergency NN cord-016990-ot1wi3xi 549 19 rooms room NNS cord-016990-ot1wi3xi 549 20 , , , cord-016990-ot1wi3xi 549 21 and and CC cord-016990-ot1wi3xi 549 22 physicians physician NNS cord-016990-ot1wi3xi 549 23 ' ' POS cord-016990-ot1wi3xi 549 24 offices office NNS cord-016990-ot1wi3xi 549 25 . . . cord-016990-ot1wi3xi 550 1 20s 20 NNS cord-016990-ot1wi3xi 551 1 Children child NNS cord-016990-ot1wi3xi 551 2 are be VBP cord-016990-ot1wi3xi 551 3 usually usually RB cord-016990-ot1wi3xi 551 4 infected infect VBN cord-016990-ot1wi3xi 551 5 by by IN cord-016990-ot1wi3xi 551 6 6 6 CD cord-016990-ot1wi3xi 551 7 years year NNS cord-016990-ot1wi3xi 551 8 of of IN cord-016990-ot1wi3xi 551 9 age age NN cord-016990-ot1wi3xi 551 10 , , , cord-016990-ot1wi3xi 551 11 resulting result VBG cord-016990-ot1wi3xi 551 12 in in IN cord-016990-ot1wi3xi 551 13 lifelong lifelong JJ cord-016990-ot1wi3xi 551 14 immunity immunity NN cord-016990-ot1wi3xi 551 15 , , , cord-016990-ot1wi3xi 551 16 and and CC cord-016990-ot1wi3xi 551 17 almost almost RB cord-016990-ot1wi3xi 551 18 all all DT cord-016990-ot1wi3xi 551 19 adults adult NNS cord-016990-ot1wi3xi 551 20 are be VBP cord-016990-ot1wi3xi 551 21 immune immune JJ cord-016990-ot1wi3xi 551 22 . . . cord-016990-ot1wi3xi 552 1 Clinical clinical JJ cord-016990-ot1wi3xi 552 2 infection infection NN cord-016990-ot1wi3xi 552 3 in in IN cord-016990-ot1wi3xi 552 4 children child NNS cord-016990-ot1wi3xi 552 5 younger young JJR cord-016990-ot1wi3xi 552 6 than than IN cord-016990-ot1wi3xi 552 7 9 9 CD cord-016990-ot1wi3xi 552 8 months month NNS cord-016990-ot1wi3xi 552 9 of of IN cord-016990-ot1wi3xi 552 10 age age NN cord-016990-ot1wi3xi 552 11 is be VBZ cord-016990-ot1wi3xi 552 12 generally generally RB cord-016990-ot1wi3xi 552 13 uncommon uncommon JJ cord-016990-ot1wi3xi 552 14 because because IN cord-016990-ot1wi3xi 552 15 of of IN cord-016990-ot1wi3xi 552 16 passive passive JJ cord-016990-ot1wi3xi 552 17 protection protection NN cord-016990-ot1wi3xi 552 18 afforded afford VBD cord-016990-ot1wi3xi 552 19 the the DT cord-016990-ot1wi3xi 552 20 infant infant NN cord-016990-ot1wi3xi 552 21 by by IN cord-016990-ot1wi3xi 552 22 the the DT cord-016990-ot1wi3xi 552 23 transfer transfer NN cord-016990-ot1wi3xi 552 24 of of IN cord-016990-ot1wi3xi 552 25 maternal maternal JJ cord-016990-ot1wi3xi 552 26 antibodies antibody NNS cord-016990-ot1wi3xi 552 27 . . . cord-016990-ot1wi3xi 553 1 However however RB cord-016990-ot1wi3xi 553 2 , , , cord-016990-ot1wi3xi 553 3 with with IN cord-016990-ot1wi3xi 553 4 the the DT cord-016990-ot1wi3xi 553 5 resurgence resurgence NN cord-016990-ot1wi3xi 553 6 of of IN cord-016990-ot1wi3xi 553 7 measles measle NNS cord-016990-ot1wi3xi 553 8 in in IN cord-016990-ot1wi3xi 553 9 the the DT cord-016990-ot1wi3xi 553 10 US US NNP cord-016990-ot1wi3xi 553 11 . . . cord-016990-ot1wi3xi 554 1 came come VBD cord-016990-ot1wi3xi 554 2 the the DT cord-016990-ot1wi3xi 554 3 realization realization NN cord-016990-ot1wi3xi 554 4 that that IN cord-016990-ot1wi3xi 554 5 most most JJS cord-016990-ot1wi3xi 554 6 women woman NNS cord-016990-ot1wi3xi 554 7 of of IN cord-016990-ot1wi3xi 554 8 childbearing childbeare VBG cord-016990-ot1wi3xi 554 9 age age NN cord-016990-ot1wi3xi 554 10 447 447 CD cord-016990-ot1wi3xi 554 11 strating strate VBG cord-016990-ot1wi3xi 554 12 active active JJ cord-016990-ot1wi3xi 554 13 replication replication NN cord-016990-ot1wi3xi 554 14 of of IN cord-016990-ot1wi3xi 554 15 influenza influenza NN cord-016990-ot1wi3xi 554 16 A a NN cord-016990-ot1wi3xi 554 17 in in IN cord-016990-ot1wi3xi 554 18 respiratory respiratory JJ cord-016990-ot1wi3xi 554 19 epithelium epithelium NN cord-016990-ot1wi3xi 554 20 in in IN cord-016990-ot1wi3xi 554 21 a a DT cord-016990-ot1wi3xi 554 22 large large JJ cord-016990-ot1wi3xi 554 23 airway airway NN cord-016990-ot1wi3xi 554 24 . . . cord-016990-ot1wi3xi 555 1 G. G. NNP cord-016990-ot1wi3xi 555 2 Electron Electron NNP cord-016990-ot1wi3xi 555 3 micrograph micrograph NN cord-016990-ot1wi3xi 555 4 of of IN cord-016990-ot1wi3xi 555 5 influenza influenza NN cord-016990-ot1wi3xi 555 6 A a DT cord-016990-ot1wi3xi 555 7 particles particle NNS cord-016990-ot1wi3xi 555 8 ( ( -LRB- cord-016990-ot1wi3xi 555 9 arrows arrow NNS cord-016990-ot1wi3xi 555 10 ) ) -RRB- cord-016990-ot1wi3xi 555 11 attached attach VBN cord-016990-ot1wi3xi 555 12 to to IN cord-016990-ot1wi3xi 555 13 the the DT cord-016990-ot1wi3xi 555 14 cilia cilia NN cord-016990-ot1wi3xi 555 15 of of IN cord-016990-ot1wi3xi 555 16 a a DT cord-016990-ot1wi3xi 555 17 rodent rodent NN cord-016990-ot1wi3xi 555 18 tracheal tracheal NN cord-016990-ot1wi3xi 555 19 epithelial epithelial JJ cord-016990-ot1wi3xi 555 20 cell cell NN cord-016990-ot1wi3xi 555 21 . . . cord-016990-ot1wi3xi 556 1 Viral viral JJ cord-016990-ot1wi3xi 556 2 ribonucleoproteins ribonucleoprotein NNS cord-016990-ot1wi3xi 556 3 are be VBP cord-016990-ot1wi3xi 556 4 evident evident JJ cord-016990-ot1wi3xi 556 5 in in IN cord-016990-ot1wi3xi 556 6 the the DT cord-016990-ot1wi3xi 556 7 central central JJ cord-016990-ot1wi3xi 556 8 aspect aspect NN cord-016990-ot1wi3xi 556 9 of of IN cord-016990-ot1wi3xi 556 10 the the DT cord-016990-ot1wi3xi 556 11 particles particle NNS cord-016990-ot1wi3xi 556 12 . . . cord-016990-ot1wi3xi 557 1 The the DT cord-016990-ot1wi3xi 557 2 hemagglutinin hemagglutinin NN cord-016990-ot1wi3xi 557 3 and and CC cord-016990-ot1wi3xi 557 4 neuraminidase neuraminidase NN cord-016990-ot1wi3xi 557 5 surface surface NN cord-016990-ot1wi3xi 557 6 glycoproteins glycoprotein NNS cord-016990-ot1wi3xi 557 7 make make VBP cord-016990-ot1wi3xi 557 8 up up RP cord-016990-ot1wi3xi 557 9 the the DT cord-016990-ot1wi3xi 557 10 peripheral peripheral JJ cord-016990-ot1wi3xi 557 11 spike spike NN cord-016990-ot1wi3xi 557 12 layer layer NN cord-016990-ot1wi3xi 557 13 . . . cord-016990-ot1wi3xi 558 1 ( ( -LRB- cord-016990-ot1wi3xi 558 2 Courtesy Courtesy NNP cord-016990-ot1wi3xi 558 3 of of IN cord-016990-ot1wi3xi 558 4 F.A. F.A. NNP cord-016990-ot1wi3xi 558 5 Murphy Murphy NNP cord-016990-ot1wi3xi 558 6 . . . cord-016990-ot1wi3xi 558 7 ) ) -RRB- cord-016990-ot1wi3xi 559 1 H. H. NNP cord-016990-ot1wi3xi 559 2 Rhabdomyolysis rhabdomyolysis NN cord-016990-ot1wi3xi 559 3 in in IN cord-016990-ot1wi3xi 559 4 a a DT cord-016990-ot1wi3xi 559 5 patient patient NN cord-016990-ot1wi3xi 559 6 with with IN cord-016990-ot1wi3xi 559 7 fatal fatal JJ cord-016990-ot1wi3xi 559 8 influenza influenza NN cord-016990-ot1wi3xi 559 9 A. a. NN cord-016990-ot1wi3xi 559 10 Bar Bar NNP cord-016990-ot1wi3xi 559 11 , , , cord-016990-ot1wi3xi 559 12 100 100 CD cord-016990-ot1wi3xi 559 13 nm nm NN cord-016990-ot1wi3xi 559 14 . . . cord-016990-ot1wi3xi 560 1 A a LS cord-016990-ot1wi3xi 560 2 , , , cord-016990-ot1wi3xi 560 3 B b NN cord-016990-ot1wi3xi 560 4 , , , cord-016990-ot1wi3xi 560 5 D D NNP cord-016990-ot1wi3xi 560 6 , , , cord-016990-ot1wi3xi 560 7 H H NNP cord-016990-ot1wi3xi 560 8 , , , cord-016990-ot1wi3xi 560 9 H&E H&E NNP cord-016990-ot1wi3xi 560 10 ; ; : cord-016990-ot1wi3xi 560 11 C C NNP cord-016990-ot1wi3xi 560 12 , , , cord-016990-ot1wi3xi 560 13 E E NNP cord-016990-ot1wi3xi 560 14 , , , cord-016990-ot1wi3xi 560 15 immunoalkaline immunoalkaline JJ cord-016990-ot1wi3xi 560 16 phosphatase phosphatase NN cord-016990-ot1wi3xi 560 17 stain stain NN cord-016990-ot1wi3xi 560 18 , , , cord-016990-ot1wi3xi 560 19 naphthol naphthol NNP cord-016990-ot1wi3xi 560 20 fast fast JJ cord-016990-ot1wi3xi 560 21 - - HYPH cord-016990-ot1wi3xi 560 22 red red NN cord-016990-ot1wi3xi 560 23 , , , cord-016990-ot1wi3xi 560 24 and and CC cord-016990-ot1wi3xi 560 25 hematoxylin hematoxylin NNP cord-016990-ot1wi3xi 560 26 counterstain counterstain NNP cord-016990-ot1wi3xi 560 27 ; ; : cord-016990-ot1wi3xi 560 28 F F NNP cord-016990-ot1wi3xi 560 29 , , , cord-016990-ot1wi3xi 560 30 digoxigenin digoxigenin NNP cord-016990-ot1wi3xi 560 31 - - HYPH cord-016990-ot1wi3xi 560 32 Iabeled Iabeled NNP cord-016990-ot1wi3xi 560 33 probe probe NN cord-016990-ot1wi3xi 560 34 followed follow VBN cord-016990-ot1wi3xi 560 35 by by IN cord-016990-ot1wi3xi 560 36 immunoalkaline immunoalkaline JJ cord-016990-ot1wi3xi 560 37 phosphatase phosphatase NN cord-016990-ot1wi3xi 560 38 staining staining NN cord-016990-ot1wi3xi 560 39 , , , cord-016990-ot1wi3xi 560 40 naphthol naphthol NNP cord-016990-ot1wi3xi 560 41 fast fast JJ cord-016990-ot1wi3xi 560 42 - - HYPH cord-016990-ot1wi3xi 560 43 red red NN cord-016990-ot1wi3xi 560 44 . . . cord-016990-ot1wi3xi 561 1 and and CC cord-016990-ot1wi3xi 561 2 hematoxylin hematoxylin NNP cord-016990-ot1wi3xi 561 3 counterstain counterstain NNP cord-016990-ot1wi3xi 561 4 ; ; : cord-016990-ot1wi3xi 561 5 G G NNP cord-016990-ot1wi3xi 561 6 , , , cord-016990-ot1wi3xi 561 7 uranyl uranyl NN cord-016990-ot1wi3xi 561 8 acetate acetate NN cord-016990-ot1wi3xi 561 9 , , , cord-016990-ot1wi3xi 561 10 lead lead JJ cord-016990-ot1wi3xi 561 11 citrate citrate NN cord-016990-ot1wi3xi 561 12 stain stain NN cord-016990-ot1wi3xi 561 13 . . . cord-016990-ot1wi3xi 562 1 acquired acquire VBN cord-016990-ot1wi3xi 562 2 immunity immunity NN cord-016990-ot1wi3xi 562 3 to to IN cord-016990-ot1wi3xi 562 4 measles measle NNS cord-016990-ot1wi3xi 562 5 through through IN cord-016990-ot1wi3xi 562 6 vaccination vaccination NN cord-016990-ot1wi3xi 562 7 and and CC cord-016990-ot1wi3xi 562 8 not not RB cord-016990-ot1wi3xi 562 9 through through IN cord-016990-ot1wi3xi 562 10 natural natural JJ cord-016990-ot1wi3xi 562 11 infection infection NN cord-016990-ot1wi3xi 562 12 . . . cord-016990-ot1wi3xi 563 1 Lower low JJR cord-016990-ot1wi3xi 563 2 levels level NNS cord-016990-ot1wi3xi 563 3 of of IN cord-016990-ot1wi3xi 563 4 maternal maternal JJ cord-016990-ot1wi3xi 563 5 antibodies antibody NNS cord-016990-ot1wi3xi 563 6 were be VBD cord-016990-ot1wi3xi 563 7 found find VBN cord-016990-ot1wi3xi 563 8 to to TO cord-016990-ot1wi3xi 563 9 be be VB cord-016990-ot1wi3xi 563 10 transferred transfer VBN cord-016990-ot1wi3xi 563 11 from from IN cord-016990-ot1wi3xi 563 12 an an DT cord-016990-ot1wi3xi 563 13 immunized immunize VBN cord-016990-ot1wi3xi 563 14 mother mother NN cord-016990-ot1wi3xi 563 15 to to IN cord-016990-ot1wi3xi 563 16 her -PRON- PRP$ cord-016990-ot1wi3xi 563 17 infant infant NN cord-016990-ot1wi3xi 563 18 ; ; : cord-016990-ot1wi3xi 563 19 thus thus RB cord-016990-ot1wi3xi 563 20 , , , cord-016990-ot1wi3xi 563 21 a a DT cord-016990-ot1wi3xi 563 22 substantial substantial JJ cord-016990-ot1wi3xi 563 23 number number NN cord-016990-ot1wi3xi 563 24 of of IN cord-016990-ot1wi3xi 563 25 measles measles NN cord-016990-ot1wi3xi 563 26 cases case NNS cord-016990-ot1wi3xi 563 27 occurred occur VBD cord-016990-ot1wi3xi 563 28 in in IN cord-016990-ot1wi3xi 563 29 children child NNS cord-016990-ot1wi3xi 563 30 younger young JJR cord-016990-ot1wi3xi 563 31 than than IN cord-016990-ot1wi3xi 563 32 1 1 CD cord-016990-ot1wi3xi 563 33 year year NN cord-016990-ot1wi3xi 563 34 of of IN cord-016990-ot1wi3xi 563 35 age age NN cord-016990-ot1wi3xi 563 36 in in IN cord-016990-ot1wi3xi 563 37 the the DT cord-016990-ot1wi3xi 563 38 US US NNP cord-016990-ot1wi3xi 563 39 . . . cord-016990-ot1wi3xi 564 1 in in IN cord-016990-ot1wi3xi 564 2 recent recent JJ cord-016990-ot1wi3xi 564 3 years year NNS cord-016990-ot1wi3xi 564 4 . . . cord-016990-ot1wi3xi 565 1 After after IN cord-016990-ot1wi3xi 565 2 an an DT cord-016990-ot1wi3xi 565 3 incubation incubation NN cord-016990-ot1wi3xi 565 4 period period NN cord-016990-ot1wi3xi 565 5 of of IN cord-016990-ot1wi3xi 565 6 about about RB cord-016990-ot1wi3xi 565 7 1 1 CD cord-016990-ot1wi3xi 565 8 to to TO cord-016990-ot1wi3xi 565 9 2 2 CD cord-016990-ot1wi3xi 565 10 weeks week NNS cord-016990-ot1wi3xi 565 11 , , , cord-016990-ot1wi3xi 565 12 the the DT cord-016990-ot1wi3xi 565 13 prodromal prodromal JJ cord-016990-ot1wi3xi 565 14 phase phase NN cord-016990-ot1wi3xi 565 15 of of IN cord-016990-ot1wi3xi 565 16 measles measle NNS cord-016990-ot1wi3xi 565 17 begins begin VBZ cord-016990-ot1wi3xi 565 18 with with IN cord-016990-ot1wi3xi 565 19 fever fever NN cord-016990-ot1wi3xi 565 20 , , , cord-016990-ot1wi3xi 565 21 rhinorrhea rhinorrhea NN cord-016990-ot1wi3xi 565 22 , , , cord-016990-ot1wi3xi 565 23 cough cough NN cord-016990-ot1wi3xi 565 24 , , , cord-016990-ot1wi3xi 565 25 and and CC cord-016990-ot1wi3xi 565 26 conjunctivitis conjunctivitis NN cord-016990-ot1wi3xi 565 27 . . . cord-016990-ot1wi3xi 566 1 Koplik Koplik NNP cord-016990-ot1wi3xi 566 2 's 's POS cord-016990-ot1wi3xi 566 3 spots spot NNS cord-016990-ot1wi3xi 566 4 , , , cord-016990-ot1wi3xi 566 5 which which WDT cord-016990-ot1wi3xi 566 6 are be VBP cord-016990-ot1wi3xi 566 7 small small JJ cord-016990-ot1wi3xi 566 8 , , , cord-016990-ot1wi3xi 566 9 irregular irregular JJ cord-016990-ot1wi3xi 566 10 red red JJ cord-016990-ot1wi3xi 566 11 spots spot NNS cord-016990-ot1wi3xi 566 12 with with IN cord-016990-ot1wi3xi 566 13 a a DT cord-016990-ot1wi3xi 566 14 bluish bluish JJ cord-016990-ot1wi3xi 566 15 - - HYPH cord-016990-ot1wi3xi 566 16 white white JJ cord-016990-ot1wi3xi 566 17 speck speck NN cord-016990-ot1wi3xi 566 18 in in IN cord-016990-ot1wi3xi 566 19 the the DT cord-016990-ot1wi3xi 566 20 center center NN cord-016990-ot1wi3xi 566 21 , , , cord-016990-ot1wi3xi 566 22 appear appear VB cord-016990-ot1wi3xi 566 23 on on IN cord-016990-ot1wi3xi 566 24 the the DT cord-016990-ot1wi3xi 566 25 buccal buccal JJ cord-016990-ot1wi3xi 566 26 mucosa mucosa NN cord-016990-ot1wi3xi 566 27 in in IN cord-016990-ot1wi3xi 566 28 50 50 CD cord-016990-ot1wi3xi 566 29 % % NN cord-016990-ot1wi3xi 566 30 to to TO cord-016990-ot1wi3xi 566 31 90 90 CD cord-016990-ot1wi3xi 566 32 % % NN cord-016990-ot1wi3xi 566 33 of of IN cord-016990-ot1wi3xi 566 34 cases case NNS cord-016990-ot1wi3xi 566 35 shortly shortly RB cord-016990-ot1wi3xi 566 36 before before IN cord-016990-ot1wi3xi 566 37 rash rash JJ cord-016990-ot1wi3xi 566 38 onset onset NN cord-016990-ot1wi3xi 566 39 . . . cord-016990-ot1wi3xi 567 1 An an DT cord-016990-ot1wi3xi 567 2 erythematous erythematous JJ cord-016990-ot1wi3xi 567 3 maculopapular maculopapular JJ cord-016990-ot1wi3xi 567 4 rash rash JJ cord-016990-ot1wi3xi 567 5 begins begin VBZ cord-016990-ot1wi3xi 567 6 on on IN cord-016990-ot1wi3xi 567 7 the the DT cord-016990-ot1wi3xi 567 8 face face NN cord-016990-ot1wi3xi 567 9 3 3 CD cord-016990-ot1wi3xi 567 10 to to TO cord-016990-ot1wi3xi 567 11 4 4 CD cord-016990-ot1wi3xi 567 12 days day NNS cord-016990-ot1wi3xi 567 13 after after IN cord-016990-ot1wi3xi 567 14 prodromal prodromal JJ cord-016990-ot1wi3xi 567 15 symptoms symptom NNS cord-016990-ot1wi3xi 567 16 and and CC cord-016990-ot1wi3xi 567 17 usually usually RB cord-016990-ot1wi3xi 567 18 spreads spread VBZ cord-016990-ot1wi3xi 567 19 to to IN cord-016990-ot1wi3xi 567 20 the the DT cord-016990-ot1wi3xi 567 21 trunk trunk NN cord-016990-ot1wi3xi 567 22 and and CC cord-016990-ot1wi3xi 567 23 extremities extremity NNS cord-016990-ot1wi3xi 567 24 . . . cord-016990-ot1wi3xi 568 1 The the DT cord-016990-ot1wi3xi 568 2 symptoms symptom NNS cord-016990-ot1wi3xi 568 3 gradually gradually RB cord-016990-ot1wi3xi 568 4 resolve resolve VBP cord-016990-ot1wi3xi 568 5 , , , cord-016990-ot1wi3xi 568 6 with with IN cord-016990-ot1wi3xi 568 7 the the DT cord-016990-ot1wi3xi 568 8 rash rash JJ cord-016990-ot1wi3xi 568 9 lasting last VBG cord-016990-ot1wi3xi 568 10 for for IN cord-016990-ot1wi3xi 568 11 approximately approximately RB cord-016990-ot1wi3xi 568 12 6 6 CD cord-016990-ot1wi3xi 568 13 days day NNS cord-016990-ot1wi3xi 568 14 , , , cord-016990-ot1wi3xi 568 15 fading fade VBG cord-016990-ot1wi3xi 568 16 in in IN cord-016990-ot1wi3xi 568 17 the the DT cord-016990-ot1wi3xi 568 18 same same JJ cord-016990-ot1wi3xi 568 19 order order NN cord-016990-ot1wi3xi 568 20 as as IN cord-016990-ot1wi3xi 568 21 it -PRON- PRP cord-016990-ot1wi3xi 568 22 appeared appear VBD cord-016990-ot1wi3xi 568 23 . . . cord-016990-ot1wi3xi 569 1 Although although IN cord-016990-ot1wi3xi 569 2 recovery recovery NN cord-016990-ot1wi3xi 569 3 is be VBZ cord-016990-ot1wi3xi 569 4 rapid rapid JJ cord-016990-ot1wi3xi 569 5 and and CC cord-016990-ot1wi3xi 569 6 complete complete JJ cord-016990-ot1wi3xi 569 7 in in IN cord-016990-ot1wi3xi 569 8 most most JJS cord-016990-ot1wi3xi 569 9 cases case NNS cord-016990-ot1wi3xi 569 10 , , , cord-016990-ot1wi3xi 569 11 complications complication NNS cord-016990-ot1wi3xi 569 12 can can MD cord-016990-ot1wi3xi 569 13 arise arise VB cord-016990-ot1wi3xi 569 14 as as IN cord-016990-ot1wi3xi 569 15 a a DT cord-016990-ot1wi3xi 569 16 result result NN cord-016990-ot1wi3xi 569 17 of of IN cord-016990-ot1wi3xi 569 18 continued continued JJ cord-016990-ot1wi3xi 569 19 and and CC cord-016990-ot1wi3xi 569 20 progressive progressive JJ cord-016990-ot1wi3xi 569 21 virus virus NN cord-016990-ot1wi3xi 569 22 replication replication NN cord-016990-ot1wi3xi 569 23 , , , cord-016990-ot1wi3xi 569 24 bacterial bacterial JJ cord-016990-ot1wi3xi 569 25 or or CC cord-016990-ot1wi3xi 569 26 viral viral JJ cord-016990-ot1wi3xi 569 27 superinfections superinfection NNS cord-016990-ot1wi3xi 569 28 , , , cord-016990-ot1wi3xi 569 29 or or CC cord-016990-ot1wi3xi 569 30 abnormal abnormal JJ cord-016990-ot1wi3xi 569 31 host host NN cord-016990-ot1wi3xi 569 32 immune immune JJ cord-016990-ot1wi3xi 569 33 response response NN cord-016990-ot1wi3xi 569 34 . . . cord-016990-ot1wi3xi 570 1 204.206.207 204.206.207 CD cord-016990-ot1wi3xi 571 1 The the DT cord-016990-ot1wi3xi 571 2 most most RBS cord-016990-ot1wi3xi 571 3 common common JJ cord-016990-ot1wi3xi 571 4 complications complication NNS cord-016990-ot1wi3xi 571 5 are be VBP cord-016990-ot1wi3xi 571 6 secondary secondary JJ cord-016990-ot1wi3xi 571 7 bacterial bacterial JJ cord-016990-ot1wi3xi 571 8 pneumonia pneumonia NN cord-016990-ot1wi3xi 571 9 and and CC cord-016990-ot1wi3xi 571 10 otitis otitis NN cord-016990-ot1wi3xi 571 11 media medium NNS cord-016990-ot1wi3xi 571 12 . . . cord-016990-ot1wi3xi 572 1 206 206 CD cord-016990-ot1wi3xi 572 2 Other other JJ cord-016990-ot1wi3xi 572 3 complications complication NNS cord-016990-ot1wi3xi 572 4 include include VBP cord-016990-ot1wi3xi 572 5 febrile febrile JJ cord-016990-ot1wi3xi 572 6 convulsions convulsion NNS cord-016990-ot1wi3xi 572 7 , , , cord-016990-ot1wi3xi 572 8 encephalitis encephalitis RB cord-016990-ot1wi3xi 572 9 , , , cord-016990-ot1wi3xi 572 10 liver liver NN cord-016990-ot1wi3xi 572 11 function function NN cord-016990-ot1wi3xi 572 12 abnormalities abnormality NNS cord-016990-ot1wi3xi 572 13 , , , cord-016990-ot1wi3xi 572 14 chronic chronic JJ cord-016990-ot1wi3xi 572 15 diarrhea diarrhea NN cord-016990-ot1wi3xi 572 16 , , , cord-016990-ot1wi3xi 572 17 and and CC cord-016990-ot1wi3xi 572 18 sinusitis sinusitis NN cord-016990-ot1wi3xi 572 19 . . . cord-016990-ot1wi3xi 573 1 Several several JJ cord-016990-ot1wi3xi 573 2 pulmonary pulmonary JJ cord-016990-ot1wi3xi 573 3 and and CC cord-016990-ot1wi3xi 573 4 central central JJ cord-016990-ot1wi3xi 573 5 nervous nervous JJ cord-016990-ot1wi3xi 573 6 system system NN cord-016990-ot1wi3xi 573 7 ( ( -LRB- cord-016990-ot1wi3xi 573 8 CNS CNS NNP cord-016990-ot1wi3xi 573 9 ) ) -RRB- cord-016990-ot1wi3xi 573 10 syndromes syndrome NNS cord-016990-ot1wi3xi 573 11 that that WDT cord-016990-ot1wi3xi 573 12 are be VBP cord-016990-ot1wi3xi 573 13 often often RB cord-016990-ot1wi3xi 573 14 fatal fatal JJ cord-016990-ot1wi3xi 573 15 have have VBP cord-016990-ot1wi3xi 573 16 been be VBN cord-016990-ot1wi3xi 573 17 described describe VBN cord-016990-ot1wi3xi 573 18 . . . cord-016990-ot1wi3xi 574 1 Death death NN cord-016990-ot1wi3xi 574 2 occurs occur VBZ cord-016990-ot1wi3xi 574 3 in in IN cord-016990-ot1wi3xi 574 4 about about RB cord-016990-ot1wi3xi 574 5 1 1 CD cord-016990-ot1wi3xi 574 6 of of IN cord-016990-ot1wi3xi 574 7 every every DT cord-016990-ot1wi3xi 574 8 1000 1000 CD cord-016990-ot1wi3xi 574 9 measles measles NN cord-016990-ot1wi3xi 574 10 cases case NNS cord-016990-ot1wi3xi 574 11 ; ; : cord-016990-ot1wi3xi 574 12 however however RB cord-016990-ot1wi3xi 574 13 , , , cord-016990-ot1wi3xi 574 14 the the DT cord-016990-ot1wi3xi 574 15 risk risk NN cord-016990-ot1wi3xi 574 16 of of IN cord-016990-ot1wi3xi 574 17 death death NN cord-016990-ot1wi3xi 574 18 and and CC cord-016990-ot1wi3xi 574 19 other other JJ cord-016990-ot1wi3xi 574 20 complications complication NNS cord-016990-ot1wi3xi 574 21 is be VBZ cord-016990-ot1wi3xi 574 22 substantially substantially RB cord-016990-ot1wi3xi 574 23 increased increase VBN cord-016990-ot1wi3xi 574 24 in in IN cord-016990-ot1wi3xi 574 25 infants infant NNS cord-016990-ot1wi3xi 574 26 , , , cord-016990-ot1wi3xi 574 27 adults adult NNS cord-016990-ot1wi3xi 574 28 , , , cord-016990-ot1wi3xi 574 29 malnourished malnourished JJ cord-016990-ot1wi3xi 574 30 and and CC cord-016990-ot1wi3xi 574 31 immunocompromised immunocompromised JJ cord-016990-ot1wi3xi 574 32 individuals individual NNS cord-016990-ot1wi3xi 574 33 , , , cord-016990-ot1wi3xi 574 34 persons person NNS cord-016990-ot1wi3xi 574 35 with with IN cord-016990-ot1wi3xi 574 36 underlying underlie VBG cord-016990-ot1wi3xi 574 37 illnesses illness NNS cord-016990-ot1wi3xi 574 38 , , , cord-016990-ot1wi3xi 574 39 and and CC cord-016990-ot1wi3xi 574 40 nonimmunized nonimmunized JJ cord-016990-ot1wi3xi 574 41 populations population NNS cord-016990-ot1wi3xi 574 42 in in IN cord-016990-ot1wi3xi 574 43 underdeveloped underdeveloped JJ cord-016990-ot1wi3xi 574 44 countries.208 countries.208 NNS cord-016990-ot1wi3xi 574 45 - - HYPH cord-016990-ot1wi3xi 574 46 212 212 CD cord-016990-ot1wi3xi 575 1 The the DT cord-016990-ot1wi3xi 575 2 first first JJ cord-016990-ot1wi3xi 575 3 step step NN cord-016990-ot1wi3xi 575 4 in in IN cord-016990-ot1wi3xi 575 5 measles measles NN cord-016990-ot1wi3xi 575 6 infection infection NN cord-016990-ot1wi3xi 575 7 is be VBZ cord-016990-ot1wi3xi 575 8 attachment attachment NN cord-016990-ot1wi3xi 575 9 of of IN cord-016990-ot1wi3xi 575 10 the the DT cord-016990-ot1wi3xi 575 11 virus virus NN cord-016990-ot1wi3xi 575 12 to to IN cord-016990-ot1wi3xi 575 13 CD46 CD46 NNP cord-016990-ot1wi3xi 575 14 cell cell NN cord-016990-ot1wi3xi 575 15 surface surface NN cord-016990-ot1wi3xi 575 16 receptors receptor NNS cord-016990-ot1wi3xi 575 17 on on IN cord-016990-ot1wi3xi 575 18 the the DT cord-016990-ot1wi3xi 575 19 respiratory respiratory NN cord-016990-ot1wi3xi 576 1 epithelium.213 epithelium.213 NNP cord-016990-ot1wi3xi 576 2 Adhesion adhesion NN cord-016990-ot1wi3xi 576 3 and and CC cord-016990-ot1wi3xi 576 4 fusion fusion NN cord-016990-ot1wi3xi 576 5 of of IN cord-016990-ot1wi3xi 576 6 the the DT cord-016990-ot1wi3xi 576 7 virus virus NN cord-016990-ot1wi3xi 576 8 to to IN cord-016990-ot1wi3xi 576 9 the the DT cord-016990-ot1wi3xi 576 10 respiratory respiratory JJ cord-016990-ot1wi3xi 576 11 epithelium epithelium NN cord-016990-ot1wi3xi 576 12 is be VBZ cord-016990-ot1wi3xi 576 13 mediated mediate VBN cord-016990-ot1wi3xi 576 14 by by IN cord-016990-ot1wi3xi 576 15 both both DT cord-016990-ot1wi3xi 576 16 the the DT cord-016990-ot1wi3xi 576 17 Hand Hand NNP cord-016990-ot1wi3xi 576 18 F F NNP cord-016990-ot1wi3xi 576 19 viral viral JJ cord-016990-ot1wi3xi 576 20 glycoproteins glycoprotein NNS cord-016990-ot1wi3xi 576 21 . . . cord-016990-ot1wi3xi 577 1 214 214 CD cord-016990-ot1wi3xi 578 1 This this DT cord-016990-ot1wi3xi 578 2 stage stage NN cord-016990-ot1wi3xi 578 3 is be VBZ cord-016990-ot1wi3xi 578 4 followed follow VBN cord-016990-ot1wi3xi 578 5 by by IN cord-016990-ot1wi3xi 578 6 local local JJ cord-016990-ot1wi3xi 578 7 replication replication NN cord-016990-ot1wi3xi 578 8 in in IN cord-016990-ot1wi3xi 578 9 respiratory respiratory JJ cord-016990-ot1wi3xi 578 10 mucosa mucosa NN cord-016990-ot1wi3xi 578 11 and and CC cord-016990-ot1wi3xi 578 12 draining drain VBG cord-016990-ot1wi3xi 578 13 lymph lymph NN cord-016990-ot1wi3xi 578 14 nodes node NNS cord-016990-ot1wi3xi 578 15 . . . cord-016990-ot1wi3xi 579 1 A a DT cord-016990-ot1wi3xi 579 2 primary primary JJ cord-016990-ot1wi3xi 579 3 viremia viremia NN cord-016990-ot1wi3xi 579 4 follows follow VBZ cord-016990-ot1wi3xi 579 5 , , , cord-016990-ot1wi3xi 579 6 with with IN cord-016990-ot1wi3xi 579 7 dissemination dissemination NN cord-016990-ot1wi3xi 579 8 Two two CD cord-016990-ot1wi3xi 579 9 types type NNS cord-016990-ot1wi3xi 579 10 of of IN cord-016990-ot1wi3xi 579 11 multinucleated multinucleated JJ cord-016990-ot1wi3xi 579 12 giant giant JJ cord-016990-ot1wi3xi 579 13 cells cell NNS cord-016990-ot1wi3xi 579 14 have have VBP cord-016990-ot1wi3xi 579 15 been be VBN cord-016990-ot1wi3xi 579 16 described describe VBN cord-016990-ot1wi3xi 579 17 in in IN cord-016990-ot1wi3xi 579 18 patient patient JJ cord-016990-ot1wi3xi 579 19 tissues tissue NNS cord-016990-ot1wi3xi 579 20 during during IN cord-016990-ot1wi3xi 579 21 measles measle NNS cord-016990-ot1wi3xi 579 22 infection infection NN cord-016990-ot1wi3xi 579 23 . . . cord-016990-ot1wi3xi 580 1 215 215 CD cord-016990-ot1wi3xi 580 2 , , , cord-016990-ot1wi3xi 580 3 216 216 CD cord-016990-ot1wi3xi 581 1 The the DT cord-016990-ot1wi3xi 581 2 reticuloendothelial reticuloendothelial JJ cord-016990-ot1wi3xi 581 3 giant giant JJ cord-016990-ot1wi3xi 581 4 cell cell NN cord-016990-ot1wi3xi 581 5 ( ( -LRB- cord-016990-ot1wi3xi 581 6 Warthin Warthin NNP cord-016990-ot1wi3xi 581 7 - - HYPH cord-016990-ot1wi3xi 581 8 Finkeldey Finkeldey NNP cord-016990-ot1wi3xi 581 9 ) ) -RRB- cord-016990-ot1wi3xi 581 10 appears appear VBZ cord-016990-ot1wi3xi 581 11 first first RB cord-016990-ot1wi3xi 581 12 during during IN cord-016990-ot1wi3xi 581 13 the the DT cord-016990-ot1wi3xi 581 14 incubation incubation NN cord-016990-ot1wi3xi 581 15 period period NN cord-016990-ot1wi3xi 581 16 and and CC cord-016990-ot1wi3xi 581 17 is be VBZ cord-016990-ot1wi3xi 581 18 seen see VBN cord-016990-ot1wi3xi 581 19 in in IN cord-016990-ot1wi3xi 581 20 449 449 CD cord-016990-ot1wi3xi 581 21 the the DT cord-016990-ot1wi3xi 581 22 nucleus nucleus NN cord-016990-ot1wi3xi 581 23 of of IN cord-016990-ot1wi3xi 581 24 a a DT cord-016990-ot1wi3xi 581 25 pneumocyte pneumocyte NN cord-016990-ot1wi3xi 581 26 in in IN cord-016990-ot1wi3xi 581 27 the the DT cord-016990-ot1wi3xi 581 28 lung lung NN cord-016990-ot1wi3xi 581 29 of of IN cord-016990-ot1wi3xi 581 30 a a DT cord-016990-ot1wi3xi 581 31 patient patient NN cord-016990-ot1wi3xi 581 32 with with IN cord-016990-ot1wi3xi 581 33 fatal fatal JJ cord-016990-ot1wi3xi 581 34 avian avian JJ cord-016990-ot1wi3xi 581 35 influenza influenza NN cord-016990-ot1wi3xi 581 36 . . . cord-016990-ot1wi3xi 582 1 Unlike unlike IN cord-016990-ot1wi3xi 582 2 other other JJ cord-016990-ot1wi3xi 582 3 influenza influenza NN cord-016990-ot1wi3xi 582 4 viruses virus NNS cord-016990-ot1wi3xi 582 5 that that WDT cord-016990-ot1wi3xi 582 6 cause cause VBP cord-016990-ot1wi3xi 582 7 disease disease NN cord-016990-ot1wi3xi 582 8 in in IN cord-016990-ot1wi3xi 582 9 humans human NNS cord-016990-ot1wi3xi 582 10 , , , cord-016990-ot1wi3xi 582 11 H5N1 H5N1 NNP cord-016990-ot1wi3xi 582 12 preferentially preferentially RB cord-016990-ot1wi3xi 582 13 infects infect VBZ cord-016990-ot1wi3xi 582 14 alveolar alveolar JJ cord-016990-ot1wi3xi 582 15 epithelial epithelial JJ cord-016990-ot1wi3xi 582 16 cells cell NNS cord-016990-ot1wi3xi 582 17 , , , cord-016990-ot1wi3xi 582 18 and and CC cord-016990-ot1wi3xi 582 19 causes cause VBZ cord-016990-ot1wi3xi 582 20 relatively relatively RB cord-016990-ot1wi3xi 582 21 minimal minimal JJ cord-016990-ot1wi3xi 582 22 pathology pathology NN cord-016990-ot1wi3xi 582 23 in in IN cord-016990-ot1wi3xi 582 24 the the DT cord-016990-ot1wi3xi 582 25 upper upper JJ cord-016990-ot1wi3xi 582 26 airway airway NN cord-016990-ot1wi3xi 582 27 . . . cord-016990-ot1wi3xi 583 1 A a DT cord-016990-ot1wi3xi 583 2 , , , cord-016990-ot1wi3xi 583 3 H&E H&E NNP cord-016990-ot1wi3xi 583 4 ; ; : cord-016990-ot1wi3xi 583 5 B B NNP cord-016990-ot1wi3xi 583 6 , , , cord-016990-ot1wi3xi 583 7 C C NNP cord-016990-ot1wi3xi 583 8 , , , cord-016990-ot1wi3xi 584 1 immunoalkaline immunoalkaline JJ cord-016990-ot1wi3xi 584 2 phosphatase phosphatase NN cord-016990-ot1wi3xi 584 3 stain stain NN cord-016990-ot1wi3xi 584 4 , , , cord-016990-ot1wi3xi 584 5 naphthol naphthol NNP cord-016990-ot1wi3xi 584 6 fast fast JJ cord-016990-ot1wi3xi 584 7 - - HYPH cord-016990-ot1wi3xi 584 8 red red NN cord-016990-ot1wi3xi 584 9 , , , cord-016990-ot1wi3xi 584 10 and and CC cord-016990-ot1wi3xi 584 11 hematoxylin hematoxylin NNP cord-016990-ot1wi3xi 584 12 counterstain counterstain NNP cord-016990-ot1wi3xi 584 13 . . . cord-016990-ot1wi3xi 585 1 different different JJ cord-016990-ot1wi3xi 585 2 lymphoid lymphoid JJ cord-016990-ot1wi3xi 585 3 tissues tissue NNS cord-016990-ot1wi3xi 585 4 throughout throughout IN cord-016990-ot1wi3xi 585 5 the the DT cord-016990-ot1wi3xi 585 6 body body NN cord-016990-ot1wi3xi 585 7 . . . cord-016990-ot1wi3xi 586 1 The the DT cord-016990-ot1wi3xi 586 2 second second JJ cord-016990-ot1wi3xi 586 3 type type NN cord-016990-ot1wi3xi 586 4 is be VBZ cord-016990-ot1wi3xi 586 5 the the DT cord-016990-ot1wi3xi 586 6 epithelial epithelial JJ cord-016990-ot1wi3xi 586 7 giant giant JJ cord-016990-ot1wi3xi 586 8 cell cell NN cord-016990-ot1wi3xi 586 9 , , , cord-016990-ot1wi3xi 586 10 which which WDT cord-016990-ot1wi3xi 586 11 has have VBZ cord-016990-ot1wi3xi 586 12 been be VBN cord-016990-ot1wi3xi 586 13 observed observe VBN cord-016990-ot1wi3xi 586 14 in in IN cord-016990-ot1wi3xi 586 15 the the DT cord-016990-ot1wi3xi 586 16 epithelium epithelium NN cord-016990-ot1wi3xi 586 17 of of IN cord-016990-ot1wi3xi 586 18 essentially essentially RB cord-016990-ot1wi3xi 586 19 every every DT cord-016990-ot1wi3xi 586 20 major major JJ cord-016990-ot1wi3xi 586 21 organ organ NN cord-016990-ot1wi3xi 586 22 . . . cord-016990-ot1wi3xi 587 1 The the DT cord-016990-ot1wi3xi 587 2 onset onset NN cord-016990-ot1wi3xi 587 3 of of IN cord-016990-ot1wi3xi 587 4 the the DT cord-016990-ot1wi3xi 587 5 rash rash NN cord-016990-ot1wi3xi 587 6 temporally temporally RB cord-016990-ot1wi3xi 587 7 coincides coincide VBZ cord-016990-ot1wi3xi 587 8 with with IN cord-016990-ot1wi3xi 587 9 the the DT cord-016990-ot1wi3xi 587 10 appearance appearance NN cord-016990-ot1wi3xi 587 11 of of IN cord-016990-ot1wi3xi 587 12 detectable detectable JJ cord-016990-ot1wi3xi 587 13 serum serum NN cord-016990-ot1wi3xi 587 14 antibody antibody NN cord-016990-ot1wi3xi 587 15 to to IN cord-016990-ot1wi3xi 587 16 measles measles NN cord-016990-ot1wi3xi 587 17 virus virus NN cord-016990-ot1wi3xi 587 18 . . . cord-016990-ot1wi3xi 588 1 Interestingly interestingly RB cord-016990-ot1wi3xi 588 2 , , , cord-016990-ot1wi3xi 588 3 virus virus NN cord-016990-ot1wi3xi 588 4 replication replication NN cord-016990-ot1wi3xi 588 5 and and CC cord-016990-ot1wi3xi 588 6 giant giant JJ cord-016990-ot1wi3xi 588 7 cell cell NN cord-016990-ot1wi3xi 588 8 formation formation NN cord-016990-ot1wi3xi 588 9 cease cease VBP cord-016990-ot1wi3xi 588 10 with with IN cord-016990-ot1wi3xi 588 11 the the DT cord-016990-ot1wi3xi 588 12 appearance appearance NN cord-016990-ot1wi3xi 588 13 of of IN cord-016990-ot1wi3xi 588 14 rash rash NN cord-016990-ot1wi3xi 588 15 . . . cord-016990-ot1wi3xi 589 1 T t NN cord-016990-ot1wi3xi 589 2 - - HYPH cord-016990-ot1wi3xi 589 3 cell cell NN cord-016990-ot1wi3xi 589 4 immunity immunity NN cord-016990-ot1wi3xi 589 5 is be VBZ cord-016990-ot1wi3xi 589 6 essential essential JJ cord-016990-ot1wi3xi 589 7 in in IN cord-016990-ot1wi3xi 589 8 the the DT cord-016990-ot1wi3xi 589 9 process process NN cord-016990-ot1wi3xi 589 10 of of IN cord-016990-ot1wi3xi 589 11 viral viral JJ cord-016990-ot1wi3xi 589 12 clearance clearance NN cord-016990-ot1wi3xi 589 13 from from IN cord-016990-ot1wi3xi 589 14 lymphoid lymphoid JJ cord-016990-ot1wi3xi 589 15 tissue tissue NN cord-016990-ot1wi3xi 589 16 and and CC cord-016990-ot1wi3xi 589 17 respiratory respiratory JJ cord-016990-ot1wi3xi 589 18 tract tract NN cord-016990-ot1wi3xi 589 19 . . . cord-016990-ot1wi3xi 590 1 While while IN cord-016990-ot1wi3xi 590 2 children child NNS cord-016990-ot1wi3xi 590 3 with with IN cord-016990-ot1wi3xi 590 4 congenital congenital JJ cord-016990-ot1wi3xi 590 5 agammaglobulinemia agammaglobulinemia NN cord-016990-ot1wi3xi 590 6 respond respond VBP cord-016990-ot1wi3xi 590 7 normally normally RB cord-016990-ot1wi3xi 590 8 to to IN cord-016990-ot1wi3xi 590 9 measles measles VB cord-016990-ot1wi3xi 590 10 virus virus NN cord-016990-ot1wi3xi 590 11 infection infection NN cord-016990-ot1wi3xi 590 12 , , , cord-016990-ot1wi3xi 590 13 patients patient NNS cord-016990-ot1wi3xi 590 14 with with IN cord-016990-ot1wi3xi 590 15 cell cell NN cord-016990-ot1wi3xi 590 16 - - HYPH cord-016990-ot1wi3xi 590 17 mediated mediate VBN cord-016990-ot1wi3xi 590 18 immunodeficiency immunodeficiency NN cord-016990-ot1wi3xi 590 19 develop develop VB cord-016990-ot1wi3xi 590 20 severe severe JJ cord-016990-ot1wi3xi 590 21 disease disease NN cord-016990-ot1wi3xi 590 22 that that WDT cord-016990-ot1wi3xi 590 23 presents present VBZ cord-016990-ot1wi3xi 590 24 as as IN cord-016990-ot1wi3xi 590 25 giant giant JJ cord-016990-ot1wi3xi 590 26 - - HYPH cord-016990-ot1wi3xi 590 27 cell cell NN cord-016990-ot1wi3xi 590 28 pneumonia pneumonia NN cord-016990-ot1wi3xi 590 29 or or CC cord-016990-ot1wi3xi 590 30 encephalopathy encephalopathy NN cord-016990-ot1wi3xi 590 31 in in IN cord-016990-ot1wi3xi 590 32 the the DT cord-016990-ot1wi3xi 590 33 absence absence NN cord-016990-ot1wi3xi 590 34 of of IN cord-016990-ot1wi3xi 590 35 an an DT cord-016990-ot1wi3xi 590 36 exanthem exanthem NN cord-016990-ot1wi3xi 590 37 . . . cord-016990-ot1wi3xi 591 1 [ [ -LRB- cord-016990-ot1wi3xi 591 2 208 208 CD cord-016990-ot1wi3xi 591 3 ] ] -RRB- cord-016990-ot1wi3xi 591 4 [ [ -LRB- cord-016990-ot1wi3xi 591 5 209 209 CD cord-016990-ot1wi3xi 591 6 ] ] -RRB- cord-016990-ot1wi3xi 591 7 [ [ -LRB- cord-016990-ot1wi3xi 591 8 210 210 CD cord-016990-ot1wi3xi 591 9 ] ] -RRB- cord-016990-ot1wi3xi 591 10 [ [ -LRB- cord-016990-ot1wi3xi 591 11 211 211 CD cord-016990-ot1wi3xi 591 12 ] ] -RRB- cord-016990-ot1wi3xi 591 13 217 217 CD cord-016990-ot1wi3xi 591 14 , , , cord-016990-ot1wi3xi 591 15 218 218 CD cord-016990-ot1wi3xi 591 16 Immunity immunity NN cord-016990-ot1wi3xi 591 17 to to IN cord-016990-ot1wi3xi 591 18 the the DT cord-016990-ot1wi3xi 591 19 F F NNP cord-016990-ot1wi3xi 591 20 surface surface NN cord-016990-ot1wi3xi 591 21 glycoprotein glycoprotein NN cord-016990-ot1wi3xi 591 22 is be VBZ cord-016990-ot1wi3xi 591 23 necessary necessary JJ cord-016990-ot1wi3xi 591 24 to to TO cord-016990-ot1wi3xi 591 25 prevent prevent VB cord-016990-ot1wi3xi 591 26 the the DT cord-016990-ot1wi3xi 591 27 spread spread NN cord-016990-ot1wi3xi 591 28 of of IN cord-016990-ot1wi3xi 591 29 measles measle NNS cord-016990-ot1wi3xi 591 30 infection infection NN cord-016990-ot1wi3xi 591 31 . . . cord-016990-ot1wi3xi 592 1 219 219 CD cord-016990-ot1wi3xi 593 1 An an DT cord-016990-ot1wi3xi 593 2 atypical atypical JJ cord-016990-ot1wi3xi 593 3 measles measle NNS cord-016990-ot1wi3xi 593 4 syndrome syndrome NN cord-016990-ot1wi3xi 593 5 characterized characterize VBN cord-016990-ot1wi3xi 593 6 by by IN cord-016990-ot1wi3xi 593 7 pulmonary pulmonary JJ cord-016990-ot1wi3xi 593 8 consolidation consolidation NN cord-016990-ot1wi3xi 593 9 with with IN cord-016990-ot1wi3xi 593 10 pleural pleural JJ cord-016990-ot1wi3xi 593 11 effusions effusion NNS cord-016990-ot1wi3xi 593 12 and and CC cord-016990-ot1wi3xi 593 13 hilar hilar JJ cord-016990-ot1wi3xi 593 14 adenopathy adenopathy NN cord-016990-ot1wi3xi 593 15 has have VBZ cord-016990-ot1wi3xi 593 16 been be VBN cord-016990-ot1wi3xi 593 17 reported report VBN cord-016990-ot1wi3xi 593 18 in in IN cord-016990-ot1wi3xi 593 19 children child NNS cord-016990-ot1wi3xi 593 20 exposed expose VBN cord-016990-ot1wi3xi 593 21 to to IN cord-016990-ot1wi3xi 593 22 wild wild JJ cord-016990-ot1wi3xi 593 23 - - HYPH cord-016990-ot1wi3xi 593 24 type type NN cord-016990-ot1wi3xi 593 25 measles measle NNS cord-016990-ot1wi3xi 593 26 virus virus NN cord-016990-ot1wi3xi 593 27 who who WP cord-016990-ot1wi3xi 593 28 had have VBD cord-016990-ot1wi3xi 593 29 previously previously RB cord-016990-ot1wi3xi 593 30 received receive VBN cord-016990-ot1wi3xi 593 31 the the DT cord-016990-ot1wi3xi 593 32 killed kill VBN cord-016990-ot1wi3xi 593 33 - - HYPH cord-016990-ot1wi3xi 593 34 measles measles NN cord-016990-ot1wi3xi 593 35 virus virus NN cord-016990-ot1wi3xi 593 36 vaccine.220 vaccine.220 RB cord-016990-ot1wi3xi 593 37 - - : cord-016990-ot1wi3xi 593 38 222 222 CD cord-016990-ot1wi3xi 593 39 Recipients recipient NNS cord-016990-ot1wi3xi 593 40 of of IN cord-016990-ot1wi3xi 593 41 the the DT cord-016990-ot1wi3xi 593 42 formalin formalin NN cord-016990-ot1wi3xi 593 43 - - HYPH cord-016990-ot1wi3xi 593 44 inactivated inactivate VBN cord-016990-ot1wi3xi 593 45 vaccine vaccine NN cord-016990-ot1wi3xi 593 46 have have VBP cord-016990-ot1wi3xi 593 47 a a DT cord-016990-ot1wi3xi 593 48 good good JJ cord-016990-ot1wi3xi 593 49 antibody antibody NN cord-016990-ot1wi3xi 593 50 response response NN cord-016990-ot1wi3xi 593 51 to to IN cord-016990-ot1wi3xi 593 52 the the DT cord-016990-ot1wi3xi 593 53 H h NN cord-016990-ot1wi3xi 593 54 protein protein NN cord-016990-ot1wi3xi 593 55 , , , cord-016990-ot1wi3xi 593 56 but but CC cord-016990-ot1wi3xi 593 57 antibodies antibody NNS cord-016990-ot1wi3xi 593 58 to to IN cord-016990-ot1wi3xi 593 59 the the DT cord-016990-ot1wi3xi 593 60 functional functional JJ cord-016990-ot1wi3xi 593 61 region region NN cord-016990-ot1wi3xi 593 62 of of IN cord-016990-ot1wi3xi 593 63 the the DT cord-016990-ot1wi3xi 593 64 F F NNP cord-016990-ot1wi3xi 593 65 protein protein NN cord-016990-ot1wi3xi 593 66 and and CC cord-016990-ot1wi3xi 593 67 to to IN cord-016990-ot1wi3xi 593 68 the the DT cord-016990-ot1wi3xi 593 69 nucleoprotein nucleoprotein NNP cord-016990-ot1wi3xi 593 70 are be VBP cord-016990-ot1wi3xi 593 71 weak weak JJ cord-016990-ot1wi3xi 593 72 or or CC cord-016990-ot1wi3xi 593 73 absent absent JJ cord-016990-ot1wi3xi 593 74 . . . cord-016990-ot1wi3xi 594 1 It -PRON- PRP cord-016990-ot1wi3xi 594 2 has have VBZ cord-016990-ot1wi3xi 594 3 been be VBN cord-016990-ot1wi3xi 594 4 suggested suggest VBN cord-016990-ot1wi3xi 594 5 that that IN cord-016990-ot1wi3xi 594 6 the the DT cord-016990-ot1wi3xi 594 7 lack lack NN cord-016990-ot1wi3xi 594 8 of of IN cord-016990-ot1wi3xi 594 9 a a DT cord-016990-ot1wi3xi 594 10 functional functional JJ cord-016990-ot1wi3xi 594 11 F F NNP cord-016990-ot1wi3xi 594 12 antibody antibody NN cord-016990-ot1wi3xi 594 13 response response NN cord-016990-ot1wi3xi 594 14 may may MD cord-016990-ot1wi3xi 594 15 playa playa NNP cord-016990-ot1wi3xi 594 16 role role NN cord-016990-ot1wi3xi 594 17 in in IN cord-016990-ot1wi3xi 594 18 virus virus NN cord-016990-ot1wi3xi 594 19 spread spread NN cord-016990-ot1wi3xi 594 20 . . . cord-016990-ot1wi3xi 595 1 223 223 CD cord-016990-ot1wi3xi 596 1 The the DT cord-016990-ot1wi3xi 596 2 pathologic pathologic JJ cord-016990-ot1wi3xi 596 3 features feature NNS cord-016990-ot1wi3xi 596 4 of of IN cord-016990-ot1wi3xi 596 5 measles measle NNS cord-016990-ot1wi3xi 596 6 have have VBP cord-016990-ot1wi3xi 596 7 been be VBN cord-016990-ot1wi3xi 596 8 well well RB cord-016990-ot1wi3xi 596 9 described describe VBN cord-016990-ot1wi3xi 596 10 and and CC cord-016990-ot1wi3xi 596 11 several several JJ cord-016990-ot1wi3xi 596 12 references reference NNS cord-016990-ot1wi3xi 596 13 containing contain VBG cord-016990-ot1wi3xi 596 14 detailed detailed JJ cord-016990-ot1wi3xi 596 15 morphologic morphologic JJ cord-016990-ot1wi3xi 596 16 descriptions description NNS cord-016990-ot1wi3xi 596 17 are be VBP cord-016990-ot1wi3xi 596 18 recommended recommend VBN cord-016990-ot1wi3xi 596 19 . . . cord-016990-ot1wi3xi 597 1 13 13 CD cord-016990-ot1wi3xi 597 2 1,209.224 1,209.224 CD cord-016990-ot1wi3xi 597 3 - - SYM cord-016990-ot1wi3xi 597 4 230 230 CD cord-016990-ot1wi3xi 598 1 The the DT cord-016990-ot1wi3xi 598 2 typical typical JJ cord-016990-ot1wi3xi 598 3 morbilliform morbilliform NN cord-016990-ot1wi3xi 598 4 skin skin NN cord-016990-ot1wi3xi 598 5 lesions lesion NNS cord-016990-ot1wi3xi 598 6 , , , cord-016990-ot1wi3xi 598 7 Koplik Koplik NNP cord-016990-ot1wi3xi 598 8 's 's POS cord-016990-ot1wi3xi 598 9 spots spot NNS cord-016990-ot1wi3xi 598 10 , , , cord-016990-ot1wi3xi 598 11 and and CC cord-016990-ot1wi3xi 598 12 measles measles NNP cord-016990-ot1wi3xi 598 13 lymphadenitis lymphadenitis NNP cord-016990-ot1wi3xi 598 14 are be VBP cord-016990-ot1wi3xi 598 15 seldom seldom RB cord-016990-ot1wi3xi 598 16 seen see VBN cord-016990-ot1wi3xi 598 17 by by IN cord-016990-ot1wi3xi 598 18 the the DT cord-016990-ot1wi3xi 598 19 surgical surgical JJ cord-016990-ot1wi3xi 598 20 pathologist pathologist NN cord-016990-ot1wi3xi 598 21 since since IN cord-016990-ot1wi3xi 598 22 the the DT cord-016990-ot1wi3xi 598 23 clinical clinical JJ cord-016990-ot1wi3xi 598 24 diagnosis diagnosis NN cord-016990-ot1wi3xi 598 25 is be VBZ cord-016990-ot1wi3xi 598 26 usually usually RB cord-016990-ot1wi3xi 598 27 apparent apparent JJ cord-016990-ot1wi3xi 598 28 . . . cord-016990-ot1wi3xi 599 1 Histopathologic Histopathologic NNP cord-016990-ot1wi3xi 599 2 changes change NNS cord-016990-ot1wi3xi 599 3 in in IN cord-016990-ot1wi3xi 599 4 the the DT cord-016990-ot1wi3xi 599 5 skin skin NN cord-016990-ot1wi3xi 599 6 include include VBP cord-016990-ot1wi3xi 599 7 mild mild JJ cord-016990-ot1wi3xi 599 8 congestion congestion NN cord-016990-ot1wi3xi 599 9 , , , cord-016990-ot1wi3xi 599 10 edema edema NN cord-016990-ot1wi3xi 599 11 , , , cord-016990-ot1wi3xi 599 12 and and CC cord-016990-ot1wi3xi 599 13 a a DT cord-016990-ot1wi3xi 599 14 predominantly predominantly RB cord-016990-ot1wi3xi 599 15 mononuclear mononuclear JJ cord-016990-ot1wi3xi 599 16 infiltrate infiltrate NN cord-016990-ot1wi3xi 599 17 surrounding surround VBG cord-016990-ot1wi3xi 599 18 small small JJ cord-016990-ot1wi3xi 599 19 vessels vessel NNS cord-016990-ot1wi3xi 599 20 of of IN cord-016990-ot1wi3xi 599 21 the the DT cord-016990-ot1wi3xi 599 22 dermis dermis NN cord-016990-ot1wi3xi 599 23 , , , cord-016990-ot1wi3xi 599 24 as as RB cord-016990-ot1wi3xi 599 25 well well RB cord-016990-ot1wi3xi 599 26 as as IN cord-016990-ot1wi3xi 599 27 other other JJ cord-016990-ot1wi3xi 599 28 nonspecific nonspecific JJ cord-016990-ot1wi3xi 599 29 features feature NNS cord-016990-ot1wi3xi 599 30 . . . cord-016990-ot1wi3xi 600 1 Occasional occasional JJ cord-016990-ot1wi3xi 600 2 diagnostic diagnostic JJ cord-016990-ot1wi3xi 600 3 multinucleated multinucleate VBN cord-016990-ot1wi3xi 600 4 epithelial epithelial JJ cord-016990-ot1wi3xi 600 5 giant giant JJ cord-016990-ot1wi3xi 600 6 cells cell NNS cord-016990-ot1wi3xi 600 7 with with IN cord-016990-ot1wi3xi 600 8 eosinophilic eosinophilic JJ cord-016990-ot1wi3xi 600 9 cytoplasmic cytoplasmic JJ cord-016990-ot1wi3xi 600 10 and and CC cord-016990-ot1wi3xi 600 11 nuclear nuclear JJ cord-016990-ot1wi3xi 600 12 inclusions inclusion NNS cord-016990-ot1wi3xi 600 13 are be VBP cord-016990-ot1wi3xi 600 14 observed observe VBN cord-016990-ot1wi3xi 600 15 . . . cord-016990-ot1wi3xi 601 1 228 228 CD cord-016990-ot1wi3xi 601 2 .231 .231 CD cord-016990-ot1wi3xi 601 3 Pathognomonic Pathognomonic NNP cord-016990-ot1wi3xi 601 4 reticuloendothelial reticuloendothelial JJ cord-016990-ot1wi3xi 601 5 multinucleated multinucleate VBD cord-016990-ot1wi3xi 601 6 giant giant JJ cord-016990-ot1wi3xi 601 7 cells cell NNS cord-016990-ot1wi3xi 601 8 can can MD cord-016990-ot1wi3xi 601 9 be be VB cord-016990-ot1wi3xi 601 10 observed observe VBN cord-016990-ot1wi3xi 601 11 in in IN cord-016990-ot1wi3xi 601 12 appendix appendix NN cord-016990-ot1wi3xi 601 13 specimens specimen NNS cord-016990-ot1wi3xi 601 14 from from IN cord-016990-ot1wi3xi 601 15 patients patient NNS cord-016990-ot1wi3xi 601 16 mistakenly mistakenly RB cord-016990-ot1wi3xi 601 17 operated operate VBD cord-016990-ot1wi3xi 601 18 on on IN cord-016990-ot1wi3xi 601 19 for for IN cord-016990-ot1wi3xi 601 20 acute acute JJ cord-016990-ot1wi3xi 601 21 appendicitis appendicitis NN cord-016990-ot1wi3xi 601 22 before before IN cord-016990-ot1wi3xi 601 23 the the DT cord-016990-ot1wi3xi 601 24 emergence emergence NN cord-016990-ot1wi3xi 601 25 of of IN cord-016990-ot1wi3xi 601 26 diagnostic diagnostic JJ cord-016990-ot1wi3xi 601 27 Koplik Koplik NNP cord-016990-ot1wi3xi 601 28 's 's POS cord-016990-ot1wi3xi 601 29 spots spot NNS cord-016990-ot1wi3xi 601 30 and and CC cord-016990-ot1wi3xi 601 31 rash rash JJ cord-016990-ot1wi3xi 601 32 . . . cord-016990-ot1wi3xi 602 1 These these DT cord-016990-ot1wi3xi 602 2 cells cell NNS cord-016990-ot1wi3xi 602 3 , , , cord-016990-ot1wi3xi 602 4 which which WDT cord-016990-ot1wi3xi 602 5 have have VBP cord-016990-ot1wi3xi 602 6 been be VBN cord-016990-ot1wi3xi 602 7 reported report VBN cord-016990-ot1wi3xi 602 8 in in IN cord-016990-ot1wi3xi 602 9 various various JJ cord-016990-ot1wi3xi 602 10 lymphoreticular lymphoreticular JJ cord-016990-ot1wi3xi 602 11 tissues tissue NNS cord-016990-ot1wi3xi 602 12 throughout throughout IN cord-016990-ot1wi3xi 602 13 the the DT cord-016990-ot1wi3xi 602 14 body body NN cord-016990-ot1wi3xi 602 15 , , , cord-016990-ot1wi3xi 602 16 are be VBP cord-016990-ot1wi3xi 602 17 typically typically RB cord-016990-ot1wi3xi 602 18 large large JJ cord-016990-ot1wi3xi 602 19 and and CC cord-016990-ot1wi3xi 602 20 contain contain VBP cord-016990-ot1wi3xi 602 21 from from IN cord-016990-ot1wi3xi 602 22 a a DT cord-016990-ot1wi3xi 602 23 few few JJ cord-016990-ot1wi3xi 602 24 to to TO cord-016990-ot1wi3xi 602 25 occasionally occasionally RB cord-016990-ot1wi3xi 602 26 up up IN cord-016990-ot1wi3xi 602 27 to to TO cord-016990-ot1wi3xi 602 28 100 100 CD cord-016990-ot1wi3xi 602 29 nuclei nucleus NNS cord-016990-ot1wi3xi 602 30 . . . cord-016990-ot1wi3xi 603 1 These these DT cord-016990-ot1wi3xi 603 2 cells cell NNS cord-016990-ot1wi3xi 603 3 do do VBP cord-016990-ot1wi3xi 603 4 not not RB cord-016990-ot1wi3xi 603 5 usually usually RB cord-016990-ot1wi3xi 603 6 contain contain VB cord-016990-ot1wi3xi 603 7 viral viral JJ cord-016990-ot1wi3xi 603 8 inclusions inclusion NNS cord-016990-ot1wi3xi 603 9 . . . cord-016990-ot1wi3xi 604 1 The the DT cord-016990-ot1wi3xi 604 2 lymphoid lymphoid JJ cord-016990-ot1wi3xi 604 3 tissues tissue NNS cord-016990-ot1wi3xi 604 4 are be VBP cord-016990-ot1wi3xi 604 5 typically typically RB cord-016990-ot1wi3xi 604 6 hyperplastic hyperplastic JJ cord-016990-ot1wi3xi 604 7 , , , cord-016990-ot1wi3xi 604 8 and and CC cord-016990-ot1wi3xi 604 9 the the DT cord-016990-ot1wi3xi 604 10 architecture architecture NN cord-016990-ot1wi3xi 604 11 is be VBZ cord-016990-ot1wi3xi 604 12 partially partially RB cord-016990-ot1wi3xi 604 13 or or CC cord-016990-ot1wi3xi 604 14 totally totally RB cord-016990-ot1wi3xi 604 15 obliterated obliterate VBN cord-016990-ot1wi3xi 604 16 by by IN cord-016990-ot1wi3xi 604 17 diffuse diffuse JJ cord-016990-ot1wi3xi 604 18 proliferation proliferation NN cord-016990-ot1wi3xi 604 19 of of IN cord-016990-ot1wi3xi 604 20 immunoblasts immunoblast NNS cord-016990-ot1wi3xi 604 21 . . . cord-016990-ot1wi3xi 605 1 [ [ -LRB- cord-016990-ot1wi3xi 605 2 232 232 CD cord-016990-ot1wi3xi 605 3 ] ] -RRB- cord-016990-ot1wi3xi 605 4 [ [ -LRB- cord-016990-ot1wi3xi 605 5 233 233 CD cord-016990-ot1wi3xi 605 6 ] ] -RRB- cord-016990-ot1wi3xi 606 1 [ [ -LRB- cord-016990-ot1wi3xi 606 2 234 234 CD cord-016990-ot1wi3xi 606 3 ] ] -RRB- cord-016990-ot1wi3xi 606 4 A a DT cord-016990-ot1wi3xi 606 5 focal focal JJ cord-016990-ot1wi3xi 606 6 or or CC cord-016990-ot1wi3xi 606 7 generalized generalize VBN cord-016990-ot1wi3xi 606 8 interstitial interstitial JJ cord-016990-ot1wi3xi 606 9 pneumonitis pneumonitis NN cord-016990-ot1wi3xi 606 10 , , , cord-016990-ot1wi3xi 606 11 similar similar JJ cord-016990-ot1wi3xi 606 12 to to IN cord-016990-ot1wi3xi 606 13 that that DT cord-016990-ot1wi3xi 606 14 seen see VBN cord-016990-ot1wi3xi 606 15 in in IN cord-016990-ot1wi3xi 606 16 many many JJ cord-016990-ot1wi3xi 606 17 other other JJ cord-016990-ot1wi3xi 606 18 viral viral JJ cord-016990-ot1wi3xi 606 19 infections infection NNS cord-016990-ot1wi3xi 606 20 , , , cord-016990-ot1wi3xi 606 21 is be VBZ cord-016990-ot1wi3xi 606 22 seen see VBN cord-016990-ot1wi3xi 606 23 in in IN cord-016990-ot1wi3xi 606 24 the the DT cord-016990-ot1wi3xi 606 25 lungs lung NNS cord-016990-ot1wi3xi 606 26 of of IN cord-016990-ot1wi3xi 606 27 measles measles NN cord-016990-ot1wi3xi 606 28 patients patient NNS cord-016990-ot1wi3xi 606 29 . . . cord-016990-ot1wi3xi 607 1 Histopathologic Histopathologic NNP cord-016990-ot1wi3xi 607 2 features feature VBZ cord-016990-ot1wi3xi 607 3 seen see VBN cord-016990-ot1wi3xi 607 4 include include VBP cord-016990-ot1wi3xi 607 5 various various JJ cord-016990-ot1wi3xi 607 6 degrees degree NNS cord-016990-ot1wi3xi 607 7 of of IN cord-016990-ot1wi3xi 607 8 peribronchial peribronchial JJ cord-016990-ot1wi3xi 607 9 and and CC cord-016990-ot1wi3xi 607 10 interstitial interstitial JJ cord-016990-ot1wi3xi 607 11 mononuclear mononuclear JJ cord-016990-ot1wi3xi 607 12 cell cell NN cord-016990-ot1wi3xi 607 13 infiltrates infiltrate VBZ cord-016990-ot1wi3xi 607 14 , , , cord-016990-ot1wi3xi 607 15 squamous squamous JJ cord-016990-ot1wi3xi 607 16 metaplasia metaplasia NN cord-016990-ot1wi3xi 607 17 of of IN cord-016990-ot1wi3xi 607 18 bronchial bronchial JJ cord-016990-ot1wi3xi 607 19 endothelium endothelium NN cord-016990-ot1wi3xi 607 20 , , , cord-016990-ot1wi3xi 607 21 proliferation proliferation NN cord-016990-ot1wi3xi 607 22 of of IN cord-016990-ot1wi3xi 607 23 type type NN cord-016990-ot1wi3xi 607 24 II II NNP cord-016990-ot1wi3xi 607 25 pneumocyte pneumocyte NNP cord-016990-ot1wi3xi 607 26 alveolar alveolar NN cord-016990-ot1wi3xi 607 27 lining lining NN cord-016990-ot1wi3xi 607 28 cells cell NNS cord-016990-ot1wi3xi 607 29 , , , cord-016990-ot1wi3xi 607 30 and and CC cord-016990-ot1wi3xi 607 31 intraalveolar intraalveolar NN cord-016990-ot1wi3xi 607 32 edema edema NN cord-016990-ot1wi3xi 607 33 with with IN cord-016990-ot1wi3xi 607 34 or or CC cord-016990-ot1wi3xi 607 35 without without IN cord-016990-ot1wi3xi 607 36 mononuclear mononuclear JJ cord-016990-ot1wi3xi 607 37 cell cell NN cord-016990-ot1wi3xi 607 38 exudates exudate NNS cord-016990-ot1wi3xi 607 39 and and CC cord-016990-ot1wi3xi 607 40 hyaline hyaline JJ cord-016990-ot1wi3xi 607 41 membranes membrane NNS cord-016990-ot1wi3xi 607 42 . . . cord-016990-ot1wi3xi 608 1 Secondary secondary JJ cord-016990-ot1wi3xi 608 2 changes change NNS cord-016990-ot1wi3xi 608 3 , , , cord-016990-ot1wi3xi 608 4 such such JJ cord-016990-ot1wi3xi 608 5 as as IN cord-016990-ot1wi3xi 608 6 bacterial bacterial JJ cord-016990-ot1wi3xi 608 7 or or CC cord-016990-ot1wi3xi 608 8 viral viral JJ cord-016990-ot1wi3xi 608 9 superinfection superinfection NN cord-016990-ot1wi3xi 608 10 , , , cord-016990-ot1wi3xi 608 11 or or CC cord-016990-ot1wi3xi 608 12 organizational organizational JJ cord-016990-ot1wi3xi 608 13 changes change NNS cord-016990-ot1wi3xi 608 14 may may MD cord-016990-ot1wi3xi 608 15 alter alter VB cord-016990-ot1wi3xi 608 16 the the DT cord-016990-ot1wi3xi 608 17 original original JJ cord-016990-ot1wi3xi 608 18 pathology pathology NN cord-016990-ot1wi3xi 608 19 . . . cord-016990-ot1wi3xi 609 1 The the DT cord-016990-ot1wi3xi 609 2 hallmark hallmark NN cord-016990-ot1wi3xi 609 3 of of IN cord-016990-ot1wi3xi 609 4 the the DT cord-016990-ot1wi3xi 609 5 disease disease NN cord-016990-ot1wi3xi 609 6 is be VBZ cord-016990-ot1wi3xi 609 7 the the DT cord-016990-ot1wi3xi 609 8 formation formation NN cord-016990-ot1wi3xi 609 9 of of IN cord-016990-ot1wi3xi 609 10 multinucleated multinucleated JJ cord-016990-ot1wi3xi 609 11 epithelial epithelial JJ cord-016990-ot1wi3xi 609 12 giant giant JJ cord-016990-ot1wi3xi 609 13 cells cell NNS cord-016990-ot1wi3xi 609 14 ( ( -LRB- cord-016990-ot1wi3xi 609 15 Fig Fig NNP cord-016990-ot1wi3xi 609 16 . . . cord-016990-ot1wi3xi 609 17 ll.llA ll.llA JJS cord-016990-ot1wi3xi 609 18 , , , cord-016990-ot1wi3xi 609 19 B b NN cord-016990-ot1wi3xi 609 20 ) ) -RRB- cord-016990-ot1wi3xi 609 21 . . . cord-016990-ot1wi3xi 610 1 These these DT cord-016990-ot1wi3xi 610 2 cells cell NNS cord-016990-ot1wi3xi 610 3 , , , cord-016990-ot1wi3xi 610 4 which which WDT cord-016990-ot1wi3xi 610 5 are be VBP cord-016990-ot1wi3xi 610 6 often often RB cord-016990-ot1wi3xi 610 7 numerous numerous JJ cord-016990-ot1wi3xi 610 8 , , , cord-016990-ot1wi3xi 610 9 are be VBP cord-016990-ot1wi3xi 610 10 formed form VBN cord-016990-ot1wi3xi 610 11 by by IN cord-016990-ot1wi3xi 610 12 fusion fusion NN cord-016990-ot1wi3xi 610 13 of of IN cord-016990-ot1wi3xi 610 14 bronchiolar bronchiolar JJ cord-016990-ot1wi3xi 610 15 or or CC cord-016990-ot1wi3xi 610 16 alveolar alveolar JJ cord-016990-ot1wi3xi 610 17 lining line VBG cord-016990-ot1wi3xi 610 18 epithelial epithelial JJ cord-016990-ot1wi3xi 610 19 cells cell NNS cord-016990-ot1wi3xi 610 20 ( ( -LRB- cord-016990-ot1wi3xi 610 21 Fig.ll.l1A Fig.ll.l1A NNP cord-016990-ot1wi3xi 610 22 ) ) -RRB- cord-016990-ot1wi3xi 610 23 . . . cord-016990-ot1wi3xi 611 1 In in IN cord-016990-ot1wi3xi 611 2 contrast contrast NN cord-016990-ot1wi3xi 611 3 to to IN cord-016990-ot1wi3xi 611 4 the the DT cord-016990-ot1wi3xi 611 5 reticuloendothelial reticuloendothelial JJ cord-016990-ot1wi3xi 611 6 giant giant JJ cord-016990-ot1wi3xi 611 7 cells cell NNS cord-016990-ot1wi3xi 611 8 , , , cord-016990-ot1wi3xi 611 9 these these DT cord-016990-ot1wi3xi 611 10 cells cell NNS cord-016990-ot1wi3xi 611 11 generally generally RB cord-016990-ot1wi3xi 611 12 contain contain VBP cord-016990-ot1wi3xi 611 13 characteristic characteristic JJ cord-016990-ot1wi3xi 611 14 nuclear nuclear JJ cord-016990-ot1wi3xi 611 15 and and CC cord-016990-ot1wi3xi 611 16 cytoplasmic cytoplasmic JJ cord-016990-ot1wi3xi 611 17 inclusions inclusion NNS cord-016990-ot1wi3xi 611 18 . . . cord-016990-ot1wi3xi 612 1 The the DT cord-016990-ot1wi3xi 612 2 intranuclear intranuclear NN cord-016990-ot1wi3xi 612 3 inclusions inclusion NNS cord-016990-ot1wi3xi 612 4 are be VBP cord-016990-ot1wi3xi 612 5 homogeneous homogeneous JJ cord-016990-ot1wi3xi 612 6 , , , cord-016990-ot1wi3xi 612 7 eosinophilic eosinophilic JJ cord-016990-ot1wi3xi 612 8 , , , cord-016990-ot1wi3xi 612 9 and and CC cord-016990-ot1wi3xi 612 10 surrounded surround VBN cord-016990-ot1wi3xi 612 11 by by IN cord-016990-ot1wi3xi 612 12 a a DT cord-016990-ot1wi3xi 612 13 slight slight JJ cord-016990-ot1wi3xi 612 14 indistinct indistinct JJ cord-016990-ot1wi3xi 612 15 halo halo NN cord-016990-ot1wi3xi 612 16 ( ( -LRB- cord-016990-ot1wi3xi 612 17 Fig Fig NNP cord-016990-ot1wi3xi 612 18 . . . cord-016990-ot1wi3xi 612 19 11.11C 11.11c CD cord-016990-ot1wi3xi 612 20 , , , cord-016990-ot1wi3xi 612 21 D D NNP cord-016990-ot1wi3xi 612 22 ) ) -RRB- cord-016990-ot1wi3xi 612 23 . . . cord-016990-ot1wi3xi 613 1 The the DT cord-016990-ot1wi3xi 613 2 cytoplasmic cytoplasmic JJ cord-016990-ot1wi3xi 613 3 inclusions inclusion NNS cord-016990-ot1wi3xi 613 4 are be VBP cord-016990-ot1wi3xi 613 5 deeply deeply RB cord-016990-ot1wi3xi 613 6 eosinophilic eosinophilic JJ cord-016990-ot1wi3xi 613 7 , , , cord-016990-ot1wi3xi 613 8 vary vary VBP cord-016990-ot1wi3xi 613 9 in in IN cord-016990-ot1wi3xi 613 10 size size NN cord-016990-ot1wi3xi 613 11 , , , cord-016990-ot1wi3xi 613 12 and and CC cord-016990-ot1wi3xi 613 13 some some DT cord-016990-ot1wi3xi 613 14 form form VBP cord-016990-ot1wi3xi 613 15 large large JJ cord-016990-ot1wi3xi 613 16 masses masse NNS cord-016990-ot1wi3xi 613 17 with with IN cord-016990-ot1wi3xi 613 18 a a DT cord-016990-ot1wi3xi 613 19 " " `` cord-016990-ot1wi3xi 613 20 melted melt VBN cord-016990-ot1wi3xi 613 21 tallow tallow NN cord-016990-ot1wi3xi 613 22 " " `` cord-016990-ot1wi3xi 613 23 appearance appearance NN cord-016990-ot1wi3xi 613 24 ( ( -LRB- cord-016990-ot1wi3xi 613 25 Fig Fig NNP cord-016990-ot1wi3xi 613 26 . . . cord-016990-ot1wi3xi 613 27 11.11D 11.11d CD cord-016990-ot1wi3xi 613 28 ) ) -RRB- cord-016990-ot1wi3xi 613 29 . . . cord-016990-ot1wi3xi 614 1 These these DT cord-016990-ot1wi3xi 614 2 giant giant JJ cord-016990-ot1wi3xi 614 3 cells cell NNS cord-016990-ot1wi3xi 614 4 may may MD cord-016990-ot1wi3xi 614 5 undergo undergo VB cord-016990-ot1wi3xi 614 6 degenerative degenerative JJ cord-016990-ot1wi3xi 614 7 changes change NNS cord-016990-ot1wi3xi 614 8 with with IN cord-016990-ot1wi3xi 614 9 progressive progressive JJ cord-016990-ot1wi3xi 614 10 loss loss NN cord-016990-ot1wi3xi 614 11 of of IN cord-016990-ot1wi3xi 614 12 cytoplasm cytoplasm NN cord-016990-ot1wi3xi 614 13 , , , cord-016990-ot1wi3xi 614 14 increasing increase VBG cord-016990-ot1wi3xi 614 15 basophilia basophilia NN cord-016990-ot1wi3xi 614 16 , , , cord-016990-ot1wi3xi 614 17 and and CC cord-016990-ot1wi3xi 614 18 shrinkage shrinkage NN cord-016990-ot1wi3xi 614 19 of of IN cord-016990-ot1wi3xi 614 20 nuclei nucleus NNS cord-016990-ot1wi3xi 614 21 . . . cord-016990-ot1wi3xi 615 1 The the DT cord-016990-ot1wi3xi 615 2 presence presence NN cord-016990-ot1wi3xi 615 3 of of IN cord-016990-ot1wi3xi 615 4 measles measle NNS cord-016990-ot1wi3xi 615 5 virus virus NN cord-016990-ot1wi3xi 615 6 in in IN cord-016990-ot1wi3xi 615 7 these these DT cord-016990-ot1wi3xi 615 8 giant giant JJ cord-016990-ot1wi3xi 615 9 cells cell NNS cord-016990-ot1wi3xi 615 10 may may MD cord-016990-ot1wi3xi 615 11 be be VB cord-016990-ot1wi3xi 615 12 demonstrated demonstrate VBN cord-016990-ot1wi3xi 615 13 by by IN cord-016990-ot1wi3xi 615 14 immunofluorescent,235.236 immunofluorescent,235.236 JJ cord-016990-ot1wi3xi 615 15 IHC,21o.237 IHC,21o.237 NNP cord-016990-ot1wi3xi 615 16 and and CC cord-016990-ot1wi3xi 615 17 ISH ISH NNP cord-016990-ot1wi3xi 615 18 techniques technique NNS cord-016990-ot1wi3xi 615 19 ( ( -LRB- cord-016990-ot1wi3xi 615 20 Fig.ll.llE Fig.ll.llE NNP cord-016990-ot1wi3xi 615 21 , , , cord-016990-ot1wi3xi 615 22 F F NNP cord-016990-ot1wi3xi 615 23 ) ) -RRB- cord-016990-ot1wi3xi 615 24 . . . cord-016990-ot1wi3xi 616 1 These these DT cord-016990-ot1wi3xi 616 2 giant giant JJ cord-016990-ot1wi3xi 616 3 cells cell NNS cord-016990-ot1wi3xi 616 4 can can MD cord-016990-ot1wi3xi 616 5 also also RB cord-016990-ot1wi3xi 616 6 be be VB cord-016990-ot1wi3xi 616 7 seen see VBN cord-016990-ot1wi3xi 616 8 in in IN cord-016990-ot1wi3xi 616 9 extra extra JJ cord-016990-ot1wi3xi 616 10 pulmonary pulmonary JJ cord-016990-ot1wi3xi 616 11 tissues tissue NNS cord-016990-ot1wi3xi 616 12 ( ( -LRB- cord-016990-ot1wi3xi 616 13 Fig Fig NNP cord-016990-ot1wi3xi 616 14 . . . cord-016990-ot1wi3xi 616 15 11.11 11.11 CD cord-016990-ot1wi3xi 616 16 G g NN cord-016990-ot1wi3xi 616 17 , , , cord-016990-ot1wi3xi 616 18 H H NNP cord-016990-ot1wi3xi 616 19 ) ) -RRB- cord-016990-ot1wi3xi 616 20 . . . cord-016990-ot1wi3xi 617 1 The the DT cord-016990-ot1wi3xi 617 2 diagnosis diagnosis NN cord-016990-ot1wi3xi 617 3 of of IN cord-016990-ot1wi3xi 617 4 typical typical JJ cord-016990-ot1wi3xi 617 5 cases case NNS cord-016990-ot1wi3xi 617 6 of of IN cord-016990-ot1wi3xi 617 7 measles measle NNS cord-016990-ot1wi3xi 617 8 can can MD cord-016990-ot1wi3xi 617 9 usually usually RB cord-016990-ot1wi3xi 617 10 be be VB cord-016990-ot1wi3xi 617 11 made make VBN cord-016990-ot1wi3xi 617 12 on on IN cord-016990-ot1wi3xi 617 13 the the DT cord-016990-ot1wi3xi 617 14 basis basis NN cord-016990-ot1wi3xi 617 15 of of IN cord-016990-ot1wi3xi 617 16 clinical clinical JJ cord-016990-ot1wi3xi 617 17 signs sign NNS cord-016990-ot1wi3xi 617 18 and and CC cord-016990-ot1wi3xi 617 19 symptoms symptom NNS cord-016990-ot1wi3xi 617 20 . . . cord-016990-ot1wi3xi 618 1 Other other JJ cord-016990-ot1wi3xi 618 2 causes cause NNS cord-016990-ot1wi3xi 618 3 of of IN cord-016990-ot1wi3xi 618 4 a a DT cord-016990-ot1wi3xi 618 5 similar similar JJ cord-016990-ot1wi3xi 618 6 rash rash NN cord-016990-ot1wi3xi 618 7 , , , cord-016990-ot1wi3xi 618 8 but but CC cord-016990-ot1wi3xi 618 9 without without IN cord-016990-ot1wi3xi 618 10 other other JJ cord-016990-ot1wi3xi 618 11 features feature NNS cord-016990-ot1wi3xi 618 12 of of IN cord-016990-ot1wi3xi 618 13 measles measle NNS cord-016990-ot1wi3xi 618 14 , , , cord-016990-ot1wi3xi 618 15 include include VBP cord-016990-ot1wi3xi 618 16 rubella rubella NN cord-016990-ot1wi3xi 618 17 , , , cord-016990-ot1wi3xi 618 18 dengue dengue NN cord-016990-ot1wi3xi 618 19 virus virus NN cord-016990-ot1wi3xi 618 20 , , , cord-016990-ot1wi3xi 618 21 enteroviruses enteroviruses NNP cord-016990-ot1wi3xi 618 22 , , , cord-016990-ot1wi3xi 618 23 and and CC cord-016990-ot1wi3xi 618 24 drug drug NN cord-016990-ot1wi3xi 618 25 reactions reaction NNS cord-016990-ot1wi3xi 618 26 , , , cord-016990-ot1wi3xi 618 27 especially especially RB cord-016990-ot1wi3xi 618 28 to to IN cord-016990-ot1wi3xi 618 29 ampicillin ampicillin NN cord-016990-ot1wi3xi 618 30 . . . cord-016990-ot1wi3xi 619 1 The the DT cord-016990-ot1wi3xi 619 2 typical typical JJ cord-016990-ot1wi3xi 619 3 case case NN cord-016990-ot1wi3xi 619 4 of of IN cord-016990-ot1wi3xi 619 5 measles measle NNS cord-016990-ot1wi3xi 619 6 giant giant JJ cord-016990-ot1wi3xi 619 7 - - HYPH cord-016990-ot1wi3xi 619 8 cell cell NN cord-016990-ot1wi3xi 619 9 pneumonia pneumonia NN cord-016990-ot1wi3xi 619 10 generally generally RB cord-016990-ot1wi3xi 619 11 presents present VBZ cord-016990-ot1wi3xi 619 12 little little JJ cord-016990-ot1wi3xi 619 13 diagnostic diagnostic JJ cord-016990-ot1wi3xi 619 14 difficulty difficulty NN cord-016990-ot1wi3xi 619 15 for for IN cord-016990-ot1wi3xi 619 16 the the DT cord-016990-ot1wi3xi 619 17 surgical surgical JJ cord-016990-ot1wi3xi 619 18 pathologist pathologist NN cord-016990-ot1wi3xi 619 19 . . . cord-016990-ot1wi3xi 620 1 The the DT cord-016990-ot1wi3xi 620 2 presence presence NN cord-016990-ot1wi3xi 620 3 of of IN cord-016990-ot1wi3xi 620 4 giant giant JJ cord-016990-ot1wi3xi 620 5 cells cell NNS cord-016990-ot1wi3xi 620 6 with with IN cord-016990-ot1wi3xi 620 7 both both DT cord-016990-ot1wi3xi 620 8 intranuclear intranuclear NNP cord-016990-ot1wi3xi 620 9 and and CC cord-016990-ot1wi3xi 620 10 intracytoplasmic intracytoplasmic JJ cord-016990-ot1wi3xi 620 11 inclusions inclusion NNS cord-016990-ot1wi3xi 620 12 in in IN cord-016990-ot1wi3xi 620 13 a a DT cord-016990-ot1wi3xi 620 14 setting setting NN cord-016990-ot1wi3xi 620 15 of of IN cord-016990-ot1wi3xi 620 16 interstitial interstitial JJ cord-016990-ot1wi3xi 620 17 pneumonitis pneumonitis NN cord-016990-ot1wi3xi 620 18 is be VBZ cord-016990-ot1wi3xi 620 19 highly highly RB cord-016990-ot1wi3xi 620 20 specific specific JJ cord-016990-ot1wi3xi 620 21 for for IN cord-016990-ot1wi3xi 620 22 measles measle NNS cord-016990-ot1wi3xi 620 23 infection infection NN cord-016990-ot1wi3xi 620 24 . . . cord-016990-ot1wi3xi 621 1 However however RB cord-016990-ot1wi3xi 621 2 , , , cord-016990-ot1wi3xi 621 3 multinucleated multinucleated JJ cord-016990-ot1wi3xi 621 4 giant giant JJ cord-016990-ot1wi3xi 621 5 cells cell NNS cord-016990-ot1wi3xi 621 6 are be VBP cord-016990-ot1wi3xi 621 7 not not RB cord-016990-ot1wi3xi 621 8 seen see VBN cord-016990-ot1wi3xi 621 9 in in IN cord-016990-ot1wi3xi 621 10 all all DT cord-016990-ot1wi3xi 621 11 cases case NNS cord-016990-ot1wi3xi 621 12 of of IN cord-016990-ot1wi3xi 621 13 measles measles JJ cord-016990-ot1wi3xi 621 14 pneumonia pneumonia NN cord-016990-ot1wi3xi 621 15 and and CC cord-016990-ot1wi3xi 621 16 their -PRON- PRP$ cord-016990-ot1wi3xi 621 17 absence absence NN cord-016990-ot1wi3xi 621 18 should should MD cord-016990-ot1wi3xi 621 19 not not RB cord-016990-ot1wi3xi 621 20 exclude exclude VB cord-016990-ot1wi3xi 621 21 the the DT cord-016990-ot1wi3xi 621 22 J J NNP cord-016990-ot1wi3xi 621 23 diagnosis diagnosis NN cord-016990-ot1wi3xi 621 24 . . . cord-016990-ot1wi3xi 622 1 Other other JJ cord-016990-ot1wi3xi 622 2 viral viral JJ cord-016990-ot1wi3xi 622 3 and and CC cord-016990-ot1wi3xi 622 4 rickettsial rickettsial JJ cord-016990-ot1wi3xi 622 5 agents agent NNS cord-016990-ot1wi3xi 622 6 may may MD cord-016990-ot1wi3xi 622 7 also also RB cord-016990-ot1wi3xi 622 8 cause cause VB cord-016990-ot1wi3xi 622 9 a a DT cord-016990-ot1wi3xi 622 10 similar similar JJ cord-016990-ot1wi3xi 622 11 interstitial interstitial JJ cord-016990-ot1wi3xi 622 12 pneumonitis pneumonitis NN cord-016990-ot1wi3xi 622 13 , , , cord-016990-ot1wi3xi 622 14 but but CC cord-016990-ot1wi3xi 622 15 without without IN cord-016990-ot1wi3xi 622 16 the the DT cord-016990-ot1wi3xi 622 17 typical typical JJ cord-016990-ot1wi3xi 622 18 giant giant JJ cord-016990-ot1wi3xi 622 19 cells cell NNS cord-016990-ot1wi3xi 622 20 , , , cord-016990-ot1wi3xi 622 21 and and CC cord-016990-ot1wi3xi 622 22 should should MD cord-016990-ot1wi3xi 622 23 be be VB cord-016990-ot1wi3xi 622 24 differentiated differentiate VBN cord-016990-ot1wi3xi 622 25 . . . cord-016990-ot1wi3xi 623 1 229 229 CD cord-016990-ot1wi3xi 624 1 As as IN cord-016990-ot1wi3xi 624 2 previously previously RB cord-016990-ot1wi3xi 624 3 noted note VBN cord-016990-ot1wi3xi 624 4 , , , cord-016990-ot1wi3xi 624 5 the the DT cord-016990-ot1wi3xi 624 6 histopathologic histopathologic NNP cord-016990-ot1wi3xi 624 7 features feature NNS cord-016990-ot1wi3xi 624 8 in in IN cord-016990-ot1wi3xi 624 9 measles measles NN cord-016990-ot1wi3xi 624 10 pneumonia pneumonia NN cord-016990-ot1wi3xi 624 11 can can MD cord-016990-ot1wi3xi 624 12 be be VB cord-016990-ot1wi3xi 624 13 somewhat somewhat RB cord-016990-ot1wi3xi 624 14 variable,226 variable,226 JJ cord-016990-ot1wi3xi 624 15 and and CC cord-016990-ot1wi3xi 624 16 secondary secondary JJ cord-016990-ot1wi3xi 624 17 bacterial bacterial JJ cord-016990-ot1wi3xi 624 18 and and CC cord-016990-ot1wi3xi 624 19 viral viral JJ cord-016990-ot1wi3xi 624 20 infections infection NNS cord-016990-ot1wi3xi 624 21 may may MD cord-016990-ot1wi3xi 624 22 modify modify VB cord-016990-ot1wi3xi 624 23 the the DT cord-016990-ot1wi3xi 624 24 histology histology NN cord-016990-ot1wi3xi 624 25 , , , cord-016990-ot1wi3xi 624 26 further further RB cord-016990-ot1wi3xi 624 27 complicating complicate VBG cord-016990-ot1wi3xi 624 28 the the DT cord-016990-ot1wi3xi 624 29 pathologic pathologic JJ cord-016990-ot1wi3xi 624 30 diagnosis diagnosis NN cord-016990-ot1wi3xi 624 31 ( ( -LRB- cord-016990-ot1wi3xi 624 32 Fig Fig NNP cord-016990-ot1wi3xi 624 33 . . . cord-016990-ot1wi3xi 624 34 _SP cord-016990-ot1wi3xi 624 35 11.5D 11.5d CD cord-016990-ot1wi3xi 624 36 ) ) -RRB- cord-016990-ot1wi3xi 625 1 .207.229 .207.229 . cord-016990-ot1wi3xi 626 1 Other other JJ cord-016990-ot1wi3xi 626 2 viral viral JJ cord-016990-ot1wi3xi 626 3 pathogens pathogen NNS cord-016990-ot1wi3xi 626 4 , , , cord-016990-ot1wi3xi 626 5 such such JJ cord-016990-ot1wi3xi 626 6 as as IN cord-016990-ot1wi3xi 626 7 respiratory respiratory JJ cord-016990-ot1wi3xi 626 8 syncytial syncytial NN cord-016990-ot1wi3xi 626 9 virus,238 virus,238 NN cord-016990-ot1wi3xi 626 10 parainfluenza,239.240 parainfluenza,239.240 NNP cord-016990-ot1wi3xi 626 11 VZV,241 VZV,241 NNPS cord-016990-ot1wi3xi 626 12 and and CC cord-016990-ot1wi3xi 626 13 a a DT cord-016990-ot1wi3xi 626 14 recently recently RB cord-016990-ot1wi3xi 626 15 discovered discover VBN cord-016990-ot1wi3xi 626 16 Hendra Hendra NNP cord-016990-ot1wi3xi 626 17 virus,242 virus,242 NNP cord-016990-ot1wi3xi 626 18 as as RB cord-016990-ot1wi3xi 626 19 well well RB cord-016990-ot1wi3xi 626 20 as as IN cord-016990-ot1wi3xi 626 21 granulomatous granulomatous JJ cord-016990-ot1wi3xi 626 22 diseases disease NNS cord-016990-ot1wi3xi 626 23 of of IN cord-016990-ot1wi3xi 626 24 the the DT cord-016990-ot1wi3xi 626 25 lung lung NN cord-016990-ot1wi3xi 626 26 , , , cord-016990-ot1wi3xi 626 27 may may MD cord-016990-ot1wi3xi 626 28 give give VB cord-016990-ot1wi3xi 626 29 rise rise NN cord-016990-ot1wi3xi 626 30 to to IN cord-016990-ot1wi3xi 626 31 pneumonia pneumonia NN cord-016990-ot1wi3xi 626 32 with with IN cord-016990-ot1wi3xi 626 33 giant giant JJ cord-016990-ot1wi3xi 626 34 cells cell NNS cord-016990-ot1wi3xi 626 35 and and CC cord-016990-ot1wi3xi 626 36 should should MD cord-016990-ot1wi3xi 626 37 also also RB cord-016990-ot1wi3xi 626 38 be be VB cord-016990-ot1wi3xi 626 39 considered consider VBN cord-016990-ot1wi3xi 626 40 in in IN cord-016990-ot1wi3xi 626 41 the the DT cord-016990-ot1wi3xi 626 42 differential differential JJ cord-016990-ot1wi3xi 626 43 diagnosis diagnosis NN cord-016990-ot1wi3xi 626 44 . . . cord-016990-ot1wi3xi 627 1 However however RB cord-016990-ot1wi3xi 627 2 , , , cord-016990-ot1wi3xi 627 3 these these DT cord-016990-ot1wi3xi 627 4 clinical clinical JJ cord-016990-ot1wi3xi 627 5 entities entity NNS cord-016990-ot1wi3xi 627 6 can can MD cord-016990-ot1wi3xi 627 7 be be VB cord-016990-ot1wi3xi 627 8 distinguished distinguish VBN cord-016990-ot1wi3xi 627 9 by by IN cord-016990-ot1wi3xi 627 10 history history NN cord-016990-ot1wi3xi 627 11 , , , cord-016990-ot1wi3xi 627 12 histopathologic histopathologic NNP cord-016990-ot1wi3xi 627 13 features feature NNS cord-016990-ot1wi3xi 627 14 , , , cord-016990-ot1wi3xi 627 15 and and CC cord-016990-ot1wi3xi 627 16 laboratory laboratory NN cord-016990-ot1wi3xi 627 17 tests test NNS cord-016990-ot1wi3xi 627 18 . . . cord-016990-ot1wi3xi 628 1 Immunohistochemistry237.243,244 immunohistochemistry237.243,244 IN cord-016990-ot1wi3xi 629 1 or or CC cord-016990-ot1wi3xi 629 2 ISH ISH NNP cord-016990-ot1wi3xi 629 3 243 243 CD cord-016990-ot1wi3xi 630 1 , , , cord-016990-ot1wi3xi 630 2 244 244 CD cord-016990-ot1wi3xi 630 3 tests test NNS cord-016990-ot1wi3xi 630 4 demonstrate demonstrate VBP cord-016990-ot1wi3xi 630 5 viral viral JJ cord-016990-ot1wi3xi 630 6 antigens antigen NNS cord-016990-ot1wi3xi 630 7 or or CC cord-016990-ot1wi3xi 630 8 nucleic nucleic JJ cord-016990-ot1wi3xi 630 9 acids acid NNS cord-016990-ot1wi3xi 630 10 in in IN cord-016990-ot1wi3xi 630 11 the the DT cord-016990-ot1wi3xi 630 12 majority majority NN cord-016990-ot1wi3xi 630 13 of of IN cord-016990-ot1wi3xi 630 14 cases case NNS cord-016990-ot1wi3xi 630 15 . . . cord-016990-ot1wi3xi 631 1 Laboratory laboratory NN cord-016990-ot1wi3xi 631 2 confirmation confirmation NN cord-016990-ot1wi3xi 631 3 is be VBZ cord-016990-ot1wi3xi 631 4 useful useful JJ cord-016990-ot1wi3xi 631 5 to to TO cord-016990-ot1wi3xi 631 6 avoid avoid VB cord-016990-ot1wi3xi 631 7 possible possible JJ cord-016990-ot1wi3xi 631 8 confusion confusion NN cord-016990-ot1wi3xi 631 9 with with IN cord-016990-ot1wi3xi 631 10 other other JJ cord-016990-ot1wi3xi 631 11 rash rash NN cord-016990-ot1wi3xi 631 12 - - HYPH cord-016990-ot1wi3xi 631 13 causing cause VBG cord-016990-ot1wi3xi 631 14 illnesses illness NNS cord-016990-ot1wi3xi 631 15 . . . cord-016990-ot1wi3xi 632 1 Diagnostic diagnostic JJ cord-016990-ot1wi3xi 632 2 laboratory laboratory NN cord-016990-ot1wi3xi 632 3 procedures procedure NNS cord-016990-ot1wi3xi 632 4 consist consist VBP cord-016990-ot1wi3xi 632 5 of of IN cord-016990-ot1wi3xi 632 6 direct direct JJ cord-016990-ot1wi3xi 632 7 detection detection NN cord-016990-ot1wi3xi 632 8 of of IN cord-016990-ot1wi3xi 632 9 either either CC cord-016990-ot1wi3xi 632 10 the the DT cord-016990-ot1wi3xi 632 11 virus virus NN cord-016990-ot1wi3xi 632 12 or or CC cord-016990-ot1wi3xi 632 13 the the DT cord-016990-ot1wi3xi 632 14 viral viral JJ cord-016990-ot1wi3xi 632 15 antigens antigen NNS cord-016990-ot1wi3xi 632 16 , , , cord-016990-ot1wi3xi 632 17 usually usually RB cord-016990-ot1wi3xi 632 18 by by IN cord-016990-ot1wi3xi 632 19 indirect indirect JJ cord-016990-ot1wi3xi 632 20 immunofluorescence immunofluorescence NN cord-016990-ot1wi3xi 632 21 or or CC cord-016990-ot1wi3xi 632 22 by by IN cord-016990-ot1wi3xi 632 23 serologic serologic JJ cord-016990-ot1wi3xi 632 24 methods method NNS cord-016990-ot1wi3xi 632 25 using use VBG cord-016990-ot1wi3xi 632 26 hemagglutination hemagglutination NN cord-016990-ot1wi3xi 632 27 inhibition inhibition NN cord-016990-ot1wi3xi 632 28 , , , cord-016990-ot1wi3xi 632 29 neutralization neutralization NN cord-016990-ot1wi3xi 632 30 , , , cord-016990-ot1wi3xi 632 31 or or CC cord-016990-ot1wi3xi 632 32 enzyme enzyme NN cord-016990-ot1wi3xi 632 33 immunoassay immunoassay NN cord-016990-ot1wi3xi 632 34 . . . cord-016990-ot1wi3xi 633 1 Specimens specimen NNS cord-016990-ot1wi3xi 633 2 for for IN cord-016990-ot1wi3xi 633 3 serologic serologic NN cord-016990-ot1wi3xi 633 4 testing testing NN cord-016990-ot1wi3xi 633 5 consist consist VBP cord-016990-ot1wi3xi 633 6 of of IN cord-016990-ot1wi3xi 633 7 acute acute JJ cord-016990-ot1wi3xi 633 8 - - : cord-016990-ot1wi3xi 633 9 and and CC cord-016990-ot1wi3xi 633 10 convalescent convalescent JJ cord-016990-ot1wi3xi 633 11 - - HYPH cord-016990-ot1wi3xi 633 12 phase phase NN cord-016990-ot1wi3xi 633 13 serum serum NN cord-016990-ot1wi3xi 633 14 pairs pair NNS cord-016990-ot1wi3xi 633 15 . . . cord-016990-ot1wi3xi 634 1 Antibody antibody NN cord-016990-ot1wi3xi 634 2 appears appear VBZ cord-016990-ot1wi3xi 634 3 within within IN cord-016990-ot1wi3xi 634 4 1 1 CD cord-016990-ot1wi3xi 634 5 to to IN cord-016990-ot1wi3xi 634 6 2 2 CD cord-016990-ot1wi3xi 634 7 days day NNS cord-016990-ot1wi3xi 634 8 after after IN cord-016990-ot1wi3xi 634 9 onset onset NN cord-016990-ot1wi3xi 634 10 of of IN cord-016990-ot1wi3xi 634 11 rash rash NN cord-016990-ot1wi3xi 634 12 , , , cord-016990-ot1wi3xi 634 13 and and CC cord-016990-ot1wi3xi 634 14 titers titer NNS cord-016990-ot1wi3xi 634 15 peak peak VBP cord-016990-ot1wi3xi 634 16 approximately approximately RB cord-016990-ot1wi3xi 634 17 2 2 CD cord-016990-ot1wi3xi 634 18 weeks week NNS cord-016990-ot1wi3xi 634 19 later later RB cord-016990-ot1wi3xi 634 20 . . . cord-016990-ot1wi3xi 635 1 Alternatively alternatively RB cord-016990-ot1wi3xi 635 2 , , , cord-016990-ot1wi3xi 635 3 the the DT cord-016990-ot1wi3xi 635 4 presence presence NN cord-016990-ot1wi3xi 635 5 of of IN cord-016990-ot1wi3xi 635 6 specific specific JJ cord-016990-ot1wi3xi 635 7 immunoglobulin immunoglobulin NN cord-016990-ot1wi3xi 635 8 M M NNP cord-016990-ot1wi3xi 635 9 ( ( -LRB- cord-016990-ot1wi3xi 635 10 IgM IgM NNP cord-016990-ot1wi3xi 635 11 ) ) -RRB- cord-016990-ot1wi3xi 635 12 antibody antibody NN cord-016990-ot1wi3xi 635 13 can can MD cord-016990-ot1wi3xi 635 14 be be VB cord-016990-ot1wi3xi 635 15 used use VBN cord-016990-ot1wi3xi 635 16 to to TO cord-016990-ot1wi3xi 635 17 diagnose diagnose VB cord-016990-ot1wi3xi 635 18 recent recent JJ cord-016990-ot1wi3xi 635 19 infection infection NN cord-016990-ot1wi3xi 635 20 . . . cord-016990-ot1wi3xi 636 1 245 245 CD cord-016990-ot1wi3xi 636 2 Human human JJ cord-016990-ot1wi3xi 636 3 parainfluenza parainfluenza NN cord-016990-ot1wi3xi 636 4 viruses virus NNS cord-016990-ot1wi3xi 636 5 ( ( -LRB- cord-016990-ot1wi3xi 636 6 HPIVs HPIVs NNP cord-016990-ot1wi3xi 636 7 ) ) -RRB- cord-016990-ot1wi3xi 636 8 are be VBP cord-016990-ot1wi3xi 636 9 second second JJ cord-016990-ot1wi3xi 636 10 only only RB cord-016990-ot1wi3xi 636 11 to to IN cord-016990-ot1wi3xi 636 12 RSV RSV NNP cord-016990-ot1wi3xi 636 13 as as IN cord-016990-ot1wi3xi 636 14 a a DT cord-016990-ot1wi3xi 636 15 cause cause NN cord-016990-ot1wi3xi 636 16 of of IN cord-016990-ot1wi3xi 636 17 lower low JJR cord-016990-ot1wi3xi 636 18 respiratory respiratory JJ cord-016990-ot1wi3xi 636 19 tract tract NN cord-016990-ot1wi3xi 636 20 disease disease NN cord-016990-ot1wi3xi 636 21 in in IN cord-016990-ot1wi3xi 636 22 young young JJ cord-016990-ot1wi3xi 636 23 children child NNS cord-016990-ot1wi3xi 636 24 . . . cord-016990-ot1wi3xi 637 1 Human human JJ cord-016990-ot1wi3xi 637 2 parainfluenza parainfluenza NN cord-016990-ot1wi3xi 637 3 viruses virus NNS cord-016990-ot1wi3xi 637 4 are be VBP cord-016990-ot1wi3xi 637 5 negative negative JJ cord-016990-ot1wi3xi 637 6 - - HYPH cord-016990-ot1wi3xi 637 7 sense sense NN cord-016990-ot1wi3xi 637 8 , , , cord-016990-ot1wi3xi 637 9 nonsegmented nonsegmente VBN cord-016990-ot1wi3xi 637 10 , , , cord-016990-ot1wi3xi 637 11 single single RB cord-016990-ot1wi3xi 637 12 - - HYPH cord-016990-ot1wi3xi 637 13 stranded stranded JJ cord-016990-ot1wi3xi 637 14 , , , cord-016990-ot1wi3xi 637 15 enveloped envelop VBD cord-016990-ot1wi3xi 637 16 RNA RNA NNP cord-016990-ot1wi3xi 637 17 viruses virus NNS cord-016990-ot1wi3xi 637 18 that that WDT cord-016990-ot1wi3xi 637 19 possess possess VBP cord-016990-ot1wi3xi 637 20 fusion fusion NN cord-016990-ot1wi3xi 637 21 and and CC cord-016990-ot1wi3xi 637 22 hemagglutinin hemagglutinin NN cord-016990-ot1wi3xi 637 23 - - HYPH cord-016990-ot1wi3xi 637 24 neuraminidase neuraminidase NN cord-016990-ot1wi3xi 637 25 glycoprotein glycoprotein NN cord-016990-ot1wi3xi 637 26 " " `` cord-016990-ot1wi3xi 637 27 spikes spike NNS cord-016990-ot1wi3xi 637 28 " " '' cord-016990-ot1wi3xi 637 29 on on IN cord-016990-ot1wi3xi 637 30 their -PRON- PRP$ cord-016990-ot1wi3xi 637 31 surface surface NN cord-016990-ot1wi3xi 637 32 ( ( -LRB- cord-016990-ot1wi3xi 637 33 Fig Fig NNP cord-016990-ot1wi3xi 637 34 . . . cord-016990-ot1wi3xi 637 35 11 11 CD cord-016990-ot1wi3xi 637 36 .IG .IG NFP cord-016990-ot1wi3xi 637 37 ) ) -RRB- cord-016990-ot1wi3xi 637 38 . . . cord-016990-ot1wi3xi 638 1 The the DT cord-016990-ot1wi3xi 638 2 four four CD cord-016990-ot1wi3xi 638 3 serotypes serotype NNS cord-016990-ot1wi3xi 638 4 of of IN cord-016990-ot1wi3xi 638 5 HPIV HPIV NNP cord-016990-ot1wi3xi 638 6 belong belong VBP cord-016990-ot1wi3xi 638 7 in in IN cord-016990-ot1wi3xi 638 8 the the DT cord-016990-ot1wi3xi 638 9 family family NN cord-016990-ot1wi3xi 638 10 Paramyxoviridae Paramyxoviridae NNP cord-016990-ot1wi3xi 638 11 , , , cord-016990-ot1wi3xi 638 12 subfamily subfamily NN cord-016990-ot1wi3xi 638 13 Paramyxovirinae Paramyxovirinae NNP cord-016990-ot1wi3xi 638 14 , , , cord-016990-ot1wi3xi 638 15 and and CC cord-016990-ot1wi3xi 638 16 genera genera NNP cord-016990-ot1wi3xi 638 17 Respirovirus Respirovirus NNP cord-016990-ot1wi3xi 638 18 ( ( -LRB- cord-016990-ot1wi3xi 638 19 HPIV HPIV NNP cord-016990-ot1wi3xi 638 20 - - HYPH cord-016990-ot1wi3xi 638 21 l l NNP cord-016990-ot1wi3xi 638 22 and and CC cord-016990-ot1wi3xi 638 23 -3 -3 NNP cord-016990-ot1wi3xi 638 24 ) ) -RRB- cord-016990-ot1wi3xi 638 25 and and CC cord-016990-ot1wi3xi 638 26 Rubulavirus Rubulavirus NNP cord-016990-ot1wi3xi 638 27 ( ( -LRB- cord-016990-ot1wi3xi 638 28 HPIV-2 hpiv-2 NN cord-016990-ot1wi3xi 638 29 and and CC cord-016990-ot1wi3xi 638 30 -4 -4 NNP cord-016990-ot1wi3xi 638 31 ) ) -RRB- cord-016990-ot1wi3xi 638 32 . . . cord-016990-ot1wi3xi 639 1 The the DT cord-016990-ot1wi3xi 639 2 virions virion NNS cord-016990-ot1wi3xi 639 3 are be VBP cord-016990-ot1wi3xi 639 4 variable variable JJ cord-016990-ot1wi3xi 639 5 in in IN cord-016990-ot1wi3xi 639 6 shape shape NN cord-016990-ot1wi3xi 639 7 and and CC cord-016990-ot1wi3xi 639 8 size size NN cord-016990-ot1wi3xi 639 9 , , , cord-016990-ot1wi3xi 639 10 ranging range VBG cord-016990-ot1wi3xi 639 11 from from IN cord-016990-ot1wi3xi 639 12 150 150 CD cord-016990-ot1wi3xi 639 13 to to TO cord-016990-ot1wi3xi 639 14 300 300 CD cord-016990-ot1wi3xi 639 15 nm nm NN cord-016990-ot1wi3xi 639 16 . . . cord-016990-ot1wi3xi 640 1 246 246 CD cord-016990-ot1wi3xi 640 2 Human human JJ cord-016990-ot1wi3xi 640 3 parainfluenza parainfluenza NN cord-016990-ot1wi3xi 640 4 viruses virus NNS cord-016990-ot1wi3xi 640 5 are be VBP cord-016990-ot1wi3xi 640 6 spread spread VBN cord-016990-ot1wi3xi 640 7 from from IN cord-016990-ot1wi3xi 640 8 respiratory respiratory JJ cord-016990-ot1wi3xi 640 9 secretions secretion NNS cord-016990-ot1wi3xi 640 10 through through IN cord-016990-ot1wi3xi 640 11 close close JJ cord-016990-ot1wi3xi 640 12 contact contact NN cord-016990-ot1wi3xi 640 13 with with IN cord-016990-ot1wi3xi 640 14 infected infected JJ cord-016990-ot1wi3xi 640 15 persons person NNS cord-016990-ot1wi3xi 640 16 or or CC cord-016990-ot1wi3xi 640 17 contact contact NN cord-016990-ot1wi3xi 640 18 with with IN cord-016990-ot1wi3xi 640 19 contaminated contaminated JJ cord-016990-ot1wi3xi 640 20 surfaces surface NNS cord-016990-ot1wi3xi 640 21 or or CC cord-016990-ot1wi3xi 640 22 objects object NNS cord-016990-ot1wi3xi 640 23 . . . cord-016990-ot1wi3xi 641 1 Infection infection NN cord-016990-ot1wi3xi 641 2 can can MD cord-016990-ot1wi3xi 641 3 occur occur VB cord-016990-ot1wi3xi 641 4 when when WRB cord-016990-ot1wi3xi 641 5 infectious infectious JJ cord-016990-ot1wi3xi 641 6 material material NN cord-016990-ot1wi3xi 641 7 contacts contact NNS cord-016990-ot1wi3xi 641 8 mucous mucous JJ cord-016990-ot1wi3xi 641 9 membranes membrane NNS cord-016990-ot1wi3xi 641 10 of of IN cord-016990-ot1wi3xi 641 11 the the DT cord-016990-ot1wi3xi 641 12 eyes eye NNS cord-016990-ot1wi3xi 641 13 , , , cord-016990-ot1wi3xi 641 14 mouth mouth NN cord-016990-ot1wi3xi 641 15 , , , cord-016990-ot1wi3xi 641 16 or or CC cord-016990-ot1wi3xi 641 17 nose nose NN cord-016990-ot1wi3xi 641 18 , , , cord-016990-ot1wi3xi 641 19 and and CC cord-016990-ot1wi3xi 641 20 possibly possibly RB cord-016990-ot1wi3xi 641 21 through through IN cord-016990-ot1wi3xi 641 22 the the DT cord-016990-ot1wi3xi 641 23 inhalation inhalation NN cord-016990-ot1wi3xi 641 24 of of IN cord-016990-ot1wi3xi 641 25 droplets droplet NNS cord-016990-ot1wi3xi 641 26 generated generate VBN cord-016990-ot1wi3xi 641 27 by by IN cord-016990-ot1wi3xi 641 28 a a DT cord-016990-ot1wi3xi 641 29 sneeze sneeze NN cord-016990-ot1wi3xi 641 30 or or CC cord-016990-ot1wi3xi 641 31 cough cough NN cord-016990-ot1wi3xi 641 32 . . . cord-016990-ot1wi3xi 642 1 Human human JJ cord-016990-ot1wi3xi 642 2 parainfluenza parainfluenza NN cord-016990-ot1wi3xi 642 3 viruses virus NNS cord-016990-ot1wi3xi 642 4 are be VBP cord-016990-ot1wi3xi 642 5 unstable unstable JJ cord-016990-ot1wi3xi 642 6 in in IN cord-016990-ot1wi3xi 642 7 the the DT cord-016990-ot1wi3xi 642 8 environment environment NN cord-016990-ot1wi3xi 642 9 ( ( -LRB- cord-016990-ot1wi3xi 642 10 surviving survive VBG cord-016990-ot1wi3xi 642 11 a a DT cord-016990-ot1wi3xi 642 12 few few JJ cord-016990-ot1wi3xi 642 13 hours hour NNS cord-016990-ot1wi3xi 642 14 on on IN cord-016990-ot1wi3xi 642 15 environmental environmental JJ cord-016990-ot1wi3xi 642 16 surfaces surface NNS cord-016990-ot1wi3xi 642 17 ) ) -RRB- cord-016990-ot1wi3xi 642 18 , , , cord-016990-ot1wi3xi 642 19 and and CC cord-016990-ot1wi3xi 642 20 are be VBP cord-016990-ot1wi3xi 642 21 readily readily RB cord-016990-ot1wi3xi 642 22 inactivated inactivate VBN cord-016990-ot1wi3xi 642 23 with with IN cord-016990-ot1wi3xi 642 24 soap soap NN cord-016990-ot1wi3xi 642 25 and and CC cord-016990-ot1wi3xi 642 26 water water NN cord-016990-ot1wi3xi 642 27 . . . cord-016990-ot1wi3xi 643 1 They -PRON- PRP cord-016990-ot1wi3xi 643 2 are be VBP cord-016990-ot1wi3xi 643 3 ubiquitous ubiquitous JJ cord-016990-ot1wi3xi 643 4 , , , cord-016990-ot1wi3xi 643 5 and and CC cord-016990-ot1wi3xi 643 6 infect infect VB cord-016990-ot1wi3xi 643 7 most most JJS cord-016990-ot1wi3xi 643 8 S S NNP cord-016990-ot1wi3xi 643 9 , , , cord-016990-ot1wi3xi 643 10 R. R. NNP cord-016990-ot1wi3xi 643 11 Zaki Zaki NNP cord-016990-ot1wi3xi 643 12 and and CC cord-016990-ot1wi3xi 643 13 CD CD NNP cord-016990-ot1wi3xi 643 14 . . . cord-016990-ot1wi3xi 644 1 Paddock paddock NN cord-016990-ot1wi3xi 644 2 people people NNS cord-016990-ot1wi3xi 644 3 during during IN cord-016990-ot1wi3xi 644 4 childhood childhood NN cord-016990-ot1wi3xi 644 5 . . . cord-016990-ot1wi3xi 645 1 The the DT cord-016990-ot1wi3xi 645 2 highest high JJS cord-016990-ot1wi3xi 645 3 rates rate NNS cord-016990-ot1wi3xi 645 4 of of IN cord-016990-ot1wi3xi 645 5 serious serious JJ cord-016990-ot1wi3xi 645 6 HPIV HPIV NNP cord-016990-ot1wi3xi 645 7 illnesses illness NNS cord-016990-ot1wi3xi 645 8 occur occur VBP cord-016990-ot1wi3xi 645 9 among among IN cord-016990-ot1wi3xi 645 10 young young JJ cord-016990-ot1wi3xi 645 11 children child NNS cord-016990-ot1wi3xi 645 12 . . . cord-016990-ot1wi3xi 646 1 Serologic Serologic NNP cord-016990-ot1wi3xi 646 2 surveys survey NNS cord-016990-ot1wi3xi 646 3 have have VBP cord-016990-ot1wi3xi 646 4 shown show VBN cord-016990-ot1wi3xi 646 5 that that IN cord-016990-ot1wi3xi 646 6 90 90 CD cord-016990-ot1wi3xi 646 7 % % NN cord-016990-ot1wi3xi 646 8 to to IN cord-016990-ot1wi3xi 646 9 100 100 CD cord-016990-ot1wi3xi 646 10 % % NN cord-016990-ot1wi3xi 646 11 of of IN cord-016990-ot1wi3xi 646 12 children child NNS cord-016990-ot1wi3xi 646 13 aged age VBN cord-016990-ot1wi3xi 646 14 5 5 CD cord-016990-ot1wi3xi 646 15 years year NNS cord-016990-ot1wi3xi 646 16 and and CC cord-016990-ot1wi3xi 646 17 older old JJR cord-016990-ot1wi3xi 646 18 have have VBP cord-016990-ot1wi3xi 646 19 antibodies antibody NNS cord-016990-ot1wi3xi 646 20 to to IN cord-016990-ot1wi3xi 646 21 HPIV-3 HPIV-3 NNP cord-016990-ot1wi3xi 646 22 , , , cord-016990-ot1wi3xi 646 23 and and CC cord-016990-ot1wi3xi 646 24 about about RB cord-016990-ot1wi3xi 646 25 75 75 CD cord-016990-ot1wi3xi 646 26 % % NN cord-016990-ot1wi3xi 646 27 have have VBP cord-016990-ot1wi3xi 646 28 antibodies antibody NNS cord-016990-ot1wi3xi 646 29 to to IN cord-016990-ot1wi3xi 646 30 HPIV HPIV NNP cord-016990-ot1wi3xi 646 31 - - HYPH cord-016990-ot1wi3xi 646 32 l l NNP cord-016990-ot1wi3xi 646 33 and and CC cord-016990-ot1wi3xi 646 34 -2 -2 NNP cord-016990-ot1wi3xi 646 35 . . . cord-016990-ot1wi3xi 647 1 The the DT cord-016990-ot1wi3xi 647 2 different different JJ cord-016990-ot1wi3xi 647 3 HPIV HPIV NNP cord-016990-ot1wi3xi 647 4 serotypes serotype NNS cord-016990-ot1wi3xi 647 5 differ differ VBP cord-016990-ot1wi3xi 647 6 in in IN cord-016990-ot1wi3xi 647 7 their -PRON- PRP$ cord-016990-ot1wi3xi 647 8 seasonality seasonality NN cord-016990-ot1wi3xi 647 9 , , , cord-016990-ot1wi3xi 647 10 with with IN cord-016990-ot1wi3xi 647 11 HPIV HPIV NNP cord-016990-ot1wi3xi 647 12 - - HYPH cord-016990-ot1wi3xi 647 13 l l NN cord-016990-ot1wi3xi 647 14 causing cause VBG cord-016990-ot1wi3xi 647 15 biennial biennial JJ cord-016990-ot1wi3xi 647 16 outbreaks outbreak NNS cord-016990-ot1wi3xi 647 17 of of IN cord-016990-ot1wi3xi 647 18 croup croup NN cord-016990-ot1wi3xi 647 19 in in IN cord-016990-ot1wi3xi 647 20 the the DT cord-016990-ot1wi3xi 647 21 fall fall NN cord-016990-ot1wi3xi 647 22 and and CC cord-016990-ot1wi3xi 647 23 HPIV-2 hpiv-2 CC cord-016990-ot1wi3xi 647 24 causing cause VBG cord-016990-ot1wi3xi 647 25 annual annual JJ cord-016990-ot1wi3xi 647 26 or or CC cord-016990-ot1wi3xi 647 27 biennial biennial JJ cord-016990-ot1wi3xi 647 28 fall fall NN cord-016990-ot1wi3xi 647 29 outbreaks outbreak NNS cord-016990-ot1wi3xi 647 30 . . . cord-016990-ot1wi3xi 648 1 Human human JJ cord-016990-ot1wi3xi 648 2 parainfluenza parainfluenza NN cord-016990-ot1wi3xi 648 3 virus-3 virus-3 NNP cord-016990-ot1wi3xi 648 4 peak peak NN cord-016990-ot1wi3xi 648 5 activity activity NN cord-016990-ot1wi3xi 648 6 occurs occur VBZ cord-016990-ot1wi3xi 648 7 during during IN cord-016990-ot1wi3xi 648 8 the the DT cord-016990-ot1wi3xi 648 9 spring spring NN cord-016990-ot1wi3xi 648 10 and and CC cord-016990-ot1wi3xi 648 11 early early JJ cord-016990-ot1wi3xi 648 12 summer summer NN cord-016990-ot1wi3xi 648 13 months month NNS cord-016990-ot1wi3xi 648 14 each each DT cord-016990-ot1wi3xi 648 15 year year NN cord-016990-ot1wi3xi 648 16 , , , cord-016990-ot1wi3xi 648 17 but but CC cord-016990-ot1wi3xi 648 18 the the DT cord-016990-ot1wi3xi 648 19 virus virus NN cord-016990-ot1wi3xi 648 20 can can MD cord-016990-ot1wi3xi 648 21 be be VB cord-016990-ot1wi3xi 648 22 isolated isolate VBN cord-016990-ot1wi3xi 648 23 throughout throughout IN cord-016990-ot1wi3xi 648 24 the the DT cord-016990-ot1wi3xi 648 25 year year NN cord-016990-ot1wi3xi 648 26 . . . cord-016990-ot1wi3xi 649 1 Similar similar JJ cord-016990-ot1wi3xi 649 2 to to IN cord-016990-ot1wi3xi 649 3 RSV RSV NNP cord-016990-ot1wi3xi 649 4 , , , cord-016990-ot1wi3xi 649 5 HPIVs HPIVs NNP cord-016990-ot1wi3xi 649 6 can can MD cord-016990-ot1wi3xi 649 7 cause cause VB cord-016990-ot1wi3xi 649 8 repeated repeat VBN cord-016990-ot1wi3xi 649 9 infections infection NNS cord-016990-ot1wi3xi 649 10 throughout throughout IN cord-016990-ot1wi3xi 649 11 life life NN cord-016990-ot1wi3xi 649 12 , , , cord-016990-ot1wi3xi 649 13 usually usually RB cord-016990-ot1wi3xi 649 14 manifested manifest VBN cord-016990-ot1wi3xi 649 15 by by IN cord-016990-ot1wi3xi 649 16 an an DT cord-016990-ot1wi3xi 649 17 upper upper JJ cord-016990-ot1wi3xi 649 18 respiratory respiratory JJ cord-016990-ot1wi3xi 649 19 tract tract NN cord-016990-ot1wi3xi 649 20 illness illness NN cord-016990-ot1wi3xi 649 21 ( ( -LRB- cord-016990-ot1wi3xi 649 22 e.g. e.g. RB cord-016990-ot1wi3xi 649 23 , , , cord-016990-ot1wi3xi 649 24 cold cold JJ cord-016990-ot1wi3xi 649 25 and and CC cord-016990-ot1wi3xi 649 26 sore sore JJ cord-016990-ot1wi3xi 649 27 throat throat NN cord-016990-ot1wi3xi 649 28 ) ) -RRB- cord-016990-ot1wi3xi 649 29 . . . cord-016990-ot1wi3xi 650 1 Human human JJ cord-016990-ot1wi3xi 650 2 parainfluenza parainfluenza NN cord-016990-ot1wi3xi 650 3 viruses virus NNS cord-016990-ot1wi3xi 650 4 can can MD cord-016990-ot1wi3xi 650 5 also also RB cord-016990-ot1wi3xi 650 6 cause cause VB cord-016990-ot1wi3xi 650 7 serious serious JJ cord-016990-ot1wi3xi 650 8 lower low JJR cord-016990-ot1wi3xi 650 9 respiratory respiratory JJ cord-016990-ot1wi3xi 650 10 tract tract NN cord-016990-ot1wi3xi 650 11 disease disease NN cord-016990-ot1wi3xi 650 12 with with IN cord-016990-ot1wi3xi 650 13 repeat repeat NN cord-016990-ot1wi3xi 650 14 infection infection NN cord-016990-ot1wi3xi 650 15 ( ( -LRB- cord-016990-ot1wi3xi 650 16 e.g. e.g. RB cord-016990-ot1wi3xi 650 17 , , , cord-016990-ot1wi3xi 650 18 pneumonia pneumonia NN cord-016990-ot1wi3xi 650 19 , , , cord-016990-ot1wi3xi 650 20 bronchitis bronchitis NN cord-016990-ot1wi3xi 650 21 , , , cord-016990-ot1wi3xi 650 22 and and CC cord-016990-ot1wi3xi 650 23 bronchiolitis bronchiolitis NNP cord-016990-ot1wi3xi 650 24 ) ) -RRB- cord-016990-ot1wi3xi 650 25 , , , cord-016990-ot1wi3xi 650 26 especially especially RB cord-016990-ot1wi3xi 650 27 among among IN cord-016990-ot1wi3xi 650 28 the the DT cord-016990-ot1wi3xi 650 29 elderly elderly JJ cord-016990-ot1wi3xi 650 30 , , , cord-016990-ot1wi3xi 650 31 and and CC cord-016990-ot1wi3xi 650 32 among among IN cord-016990-ot1wi3xi 650 33 patients patient NNS cord-016990-ot1wi3xi 650 34 with with IN cord-016990-ot1wi3xi 650 35 compromised compromised JJ cord-016990-ot1wi3xi 650 36 immune immune JJ cord-016990-ot1wi3xi 650 37 systems system NNS cord-016990-ot1wi3xi 650 38 . . . cord-016990-ot1wi3xi 651 1 Each each DT cord-016990-ot1wi3xi 651 2 of of IN cord-016990-ot1wi3xi 651 3 the the DT cord-016990-ot1wi3xi 651 4 four four CD cord-016990-ot1wi3xi 651 5 HPIVs hpiv NNS cord-016990-ot1wi3xi 651 6 has have VBZ cord-016990-ot1wi3xi 651 7 different different JJ cord-016990-ot1wi3xi 651 8 clinical clinical JJ cord-016990-ot1wi3xi 651 9 and and CC cord-016990-ot1wi3xi 651 10 epidemiologic epidemiologic JJ cord-016990-ot1wi3xi 651 11 features feature NNS cord-016990-ot1wi3xi 651 12 . . . cord-016990-ot1wi3xi 652 1 The the DT cord-016990-ot1wi3xi 652 2 most most RBS cord-016990-ot1wi3xi 652 3 distinctive distinctive JJ cord-016990-ot1wi3xi 652 4 clinical clinical JJ cord-016990-ot1wi3xi 652 5 feature feature NN cord-016990-ot1wi3xi 652 6 of of IN cord-016990-ot1wi3xi 652 7 HPIV HPIV NNP cord-016990-ot1wi3xi 652 8 - - HYPH cord-016990-ot1wi3xi 652 9 l l NNP cord-016990-ot1wi3xi 652 10 and and CC cord-016990-ot1wi3xi 652 11 HPIV-2 HPIV-2 NNP cord-016990-ot1wi3xi 652 12 is be VBZ cord-016990-ot1wi3xi 652 13 croup croup NN cord-016990-ot1wi3xi 652 14 ( ( -LRB- cord-016990-ot1wi3xi 652 15 i.e. i.e. FW cord-016990-ot1wi3xi 652 16 , , , cord-016990-ot1wi3xi 652 17 laryngotracheobronchit laryngotracheobronchit NNP cord-016990-ot1wi3xi 652 18 is be VBZ cord-016990-ot1wi3xi 652 19 ) ) -RRB- cord-016990-ot1wi3xi 652 20 ; ; : cord-016990-ot1wi3xi 652 21 HPIV HPIV NNP cord-016990-ot1wi3xi 652 22 - - HYPH cord-016990-ot1wi3xi 652 23 l l NNP cord-016990-ot1wi3xi 652 24 is be VBZ cord-016990-ot1wi3xi 652 25 the the DT cord-016990-ot1wi3xi 652 26 leading leading JJ cord-016990-ot1wi3xi 652 27 cause cause NN cord-016990-ot1wi3xi 652 28 of of IN cord-016990-ot1wi3xi 652 29 croup croup NN cord-016990-ot1wi3xi 652 30 in in IN cord-016990-ot1wi3xi 652 31 children child NNS cord-016990-ot1wi3xi 652 32 , , , cord-016990-ot1wi3xi 652 33 whereas whereas IN cord-016990-ot1wi3xi 652 34 HPIV-2 HPIV-2 NNP cord-016990-ot1wi3xi 652 35 is be VBZ cord-016990-ot1wi3xi 652 36 less less RBR cord-016990-ot1wi3xi 652 37 frequently frequently RB cord-016990-ot1wi3xi 652 38 detected detect VBN cord-016990-ot1wi3xi 652 39 . . . cord-016990-ot1wi3xi 653 1 Both both DT cord-016990-ot1wi3xi 653 2 HPIV HPIV NNP cord-016990-ot1wi3xi 653 3 - - HYPH cord-016990-ot1wi3xi 653 4 l l NNP cord-016990-ot1wi3xi 653 5 and and CC cord-016990-ot1wi3xi 653 6 -2 -2 NNP cord-016990-ot1wi3xi 653 7 can can MD cord-016990-ot1wi3xi 653 8 cause cause VB cord-016990-ot1wi3xi 653 9 other other JJ cord-016990-ot1wi3xi 653 10 upper upper JJ cord-016990-ot1wi3xi 653 11 and and CC cord-016990-ot1wi3xi 653 12 lower low JJR cord-016990-ot1wi3xi 653 13 respiratory respiratory JJ cord-016990-ot1wi3xi 653 14 tract tract NN cord-016990-ot1wi3xi 653 15 illnesses illness NNS cord-016990-ot1wi3xi 653 16 . . . cord-016990-ot1wi3xi 654 1 Human human JJ cord-016990-ot1wi3xi 654 2 parainfluenza parainfluenza NN cord-016990-ot1wi3xi 654 3 virus-3 virus-3 NNP cord-016990-ot1wi3xi 654 4 is be VBZ cord-016990-ot1wi3xi 654 5 more more RBR cord-016990-ot1wi3xi 654 6 often often RB cord-016990-ot1wi3xi 654 7 associated associate VBN cord-016990-ot1wi3xi 654 8 with with IN cord-016990-ot1wi3xi 654 9 bronchiolitis bronchiolitis NN cord-016990-ot1wi3xi 654 10 and and CC cord-016990-ot1wi3xi 654 11 pneumonia pneumonia NN cord-016990-ot1wi3xi 654 12 . . . cord-016990-ot1wi3xi 655 1 Human human JJ cord-016990-ot1wi3xi 655 2 parainfluenza parainfluenza NN cord-016990-ot1wi3xi 655 3 virus-4 virus-4 NNP cord-016990-ot1wi3xi 655 4 is be VBZ cord-016990-ot1wi3xi 655 5 infrequently infrequently RB cord-016990-ot1wi3xi 655 6 detected detect VBN cord-016990-ot1wi3xi 655 7 , , , cord-016990-ot1wi3xi 655 8 possibly possibly RB cord-016990-ot1wi3xi 655 9 because because IN cord-016990-ot1wi3xi 655 10 it -PRON- PRP cord-016990-ot1wi3xi 655 11 is be VBZ cord-016990-ot1wi3xi 655 12 less less RBR cord-016990-ot1wi3xi 655 13 likely likely JJ cord-016990-ot1wi3xi 655 14 to to TO cord-016990-ot1wi3xi 655 15 cause cause VB cord-016990-ot1wi3xi 655 16 severe severe JJ cord-016990-ot1wi3xi 655 17 disease disease NN cord-016990-ot1wi3xi 655 18 . . . cord-016990-ot1wi3xi 656 1 The the DT cord-016990-ot1wi3xi 656 2 incubation incubation NN cord-016990-ot1wi3xi 656 3 period period NN cord-016990-ot1wi3xi 656 4 for for IN cord-016990-ot1wi3xi 656 5 HPIVs hpiv NNS cord-016990-ot1wi3xi 656 6 is be VBZ cord-016990-ot1wi3xi 656 7 generally generally RB cord-016990-ot1wi3xi 656 8 from from IN cord-016990-ot1wi3xi 656 9 1 1 CD cord-016990-ot1wi3xi 656 10 to to TO cord-016990-ot1wi3xi 656 11 7 7 CD cord-016990-ot1wi3xi 656 12 days day NNS cord-016990-ot1wi3xi 656 13 . . . cord-016990-ot1wi3xi 657 1 247 247 CD cord-016990-ot1wi3xi 658 1 Most Most JJS cord-016990-ot1wi3xi 658 2 HPIV HPIV NNP cord-016990-ot1wi3xi 658 3 infections infection NNS cord-016990-ot1wi3xi 658 4 cause cause VBP cord-016990-ot1wi3xi 658 5 a a DT cord-016990-ot1wi3xi 658 6 mild mild JJ cord-016990-ot1wi3xi 658 7 , , , cord-016990-ot1wi3xi 658 8 self self NN cord-016990-ot1wi3xi 658 9 - - HYPH cord-016990-ot1wi3xi 658 10 limited limit VBN cord-016990-ot1wi3xi 658 11 illness illness NN cord-016990-ot1wi3xi 658 12 ; ; : cord-016990-ot1wi3xi 658 13 however however RB cord-016990-ot1wi3xi 658 14 , , , cord-016990-ot1wi3xi 658 15 HPIV-3 HPIV-3 NNP cord-016990-ot1wi3xi 658 16 infections infection NNS cord-016990-ot1wi3xi 658 17 are be VBP cord-016990-ot1wi3xi 658 18 an an DT cord-016990-ot1wi3xi 658 19 important important JJ cord-016990-ot1wi3xi 658 20 cause cause NN cord-016990-ot1wi3xi 658 21 of of IN cord-016990-ot1wi3xi 658 22 bronchiolitis bronchiolitis NN cord-016990-ot1wi3xi 658 23 , , , cord-016990-ot1wi3xi 658 24 croup croup NN cord-016990-ot1wi3xi 658 25 , , , cord-016990-ot1wi3xi 658 26 and and CC cord-016990-ot1wi3xi 658 27 pneumonia pneumonia NN cord-016990-ot1wi3xi 658 28 that that WDT cord-016990-ot1wi3xi 658 29 may may MD cord-016990-ot1wi3xi 658 30 be be VB cord-016990-ot1wi3xi 658 31 lifethreatening lifethreatene VBG cord-016990-ot1wi3xi 658 32 in in IN cord-016990-ot1wi3xi 658 33 infants infant NNS cord-016990-ot1wi3xi 658 34 and and CC cord-016990-ot1wi3xi 658 35 newborns newborn NNS cord-016990-ot1wi3xi 658 36 . . . cord-016990-ot1wi3xi 659 1 247 247 CD cord-016990-ot1wi3xi 659 2 Human Human NNP cord-016990-ot1wi3xi 659 3 parainfluenza parainfluenza NN cord-016990-ot1wi3xi 659 4 virus virus NN cord-016990-ot1wi3xi 659 5 infections infection NNS cord-016990-ot1wi3xi 659 6 are be VBP cord-016990-ot1wi3xi 659 7 also also RB cord-016990-ot1wi3xi 659 8 increasingly increasingly RB cord-016990-ot1wi3xi 659 9 being be VBG cord-016990-ot1wi3xi 659 10 recognized recognize VBN cord-016990-ot1wi3xi 659 11 as as IN cord-016990-ot1wi3xi 659 12 an an DT cord-016990-ot1wi3xi 659 13 important important JJ cord-016990-ot1wi3xi 659 14 cause cause NN cord-016990-ot1wi3xi 659 15 of of IN cord-016990-ot1wi3xi 659 16 severe severe JJ cord-016990-ot1wi3xi 659 17 morbidity morbidity NN cord-016990-ot1wi3xi 659 18 and and CC cord-016990-ot1wi3xi 659 19 mortality mortality NN cord-016990-ot1wi3xi 659 20 in in IN cord-016990-ot1wi3xi 659 21 immunocompromised immunocompromised JJ cord-016990-ot1wi3xi 659 22 patients patient NNS cord-016990-ot1wi3xi 659 23 . . . cord-016990-ot1wi3xi 660 1 20 20 CD cord-016990-ot1wi3xi 660 2 , , , cord-016990-ot1wi3xi 660 3 248 248 CD cord-016990-ot1wi3xi 660 4 - - HYPH cord-016990-ot1wi3xi 660 5 -252 -252 NN cord-016990-ot1wi3xi 661 1 The the DT cord-016990-ot1wi3xi 661 2 mortality mortality NN cord-016990-ot1wi3xi 661 3 of of IN cord-016990-ot1wi3xi 661 4 bone bone NN cord-016990-ot1wi3xi 661 5 marrow marrow NN cord-016990-ot1wi3xi 661 6 transplant transplant NN cord-016990-ot1wi3xi 661 7 patients patient NNS cord-016990-ot1wi3xi 661 8 with with IN cord-016990-ot1wi3xi 661 9 HPIV-3 HPIV-3 NNP cord-016990-ot1wi3xi 661 10 infection infection NN cord-016990-ot1wi3xi 661 11 has have VBZ cord-016990-ot1wi3xi 661 12 been be VBN cord-016990-ot1wi3xi 661 13 reported report VBN cord-016990-ot1wi3xi 661 14 to to TO cord-016990-ot1wi3xi 661 15 be be VB cord-016990-ot1wi3xi 661 16 as as RB cord-016990-ot1wi3xi 661 17 high high JJ cord-016990-ot1wi3xi 661 18 as as IN cord-016990-ot1wi3xi 661 19 60 60 CD cord-016990-ot1wi3xi 661 20 % % NN cord-016990-ot1wi3xi 661 21 . . . cord-016990-ot1wi3xi 662 1 249 249 CD cord-016990-ot1wi3xi 662 2 , , , cord-016990-ot1wi3xi 662 3 253 253 CD cord-016990-ot1wi3xi 663 1 , , , cord-016990-ot1wi3xi 663 2 254 254 CD cord-016990-ot1wi3xi 663 3 In in IN cord-016990-ot1wi3xi 663 4 patients patient NNS cord-016990-ot1wi3xi 663 5 with with IN cord-016990-ot1wi3xi 663 6 severe severe JJ cord-016990-ot1wi3xi 663 7 HPIV HPIV NNP cord-016990-ot1wi3xi 663 8 infection infection NN cord-016990-ot1wi3xi 663 9 , , , cord-016990-ot1wi3xi 663 10 multinucleated multinucleate VBN cord-016990-ot1wi3xi 663 11 giant giant JJ cord-016990-ot1wi3xi 663 12 cells cell NNS cord-016990-ot1wi3xi 663 13 derived derive VBN cord-016990-ot1wi3xi 663 14 from from IN cord-016990-ot1wi3xi 663 15 the the DT cord-016990-ot1wi3xi 663 16 respiratory respiratory JJ cord-016990-ot1wi3xi 663 17 epithelium epithelium NN cord-016990-ot1wi3xi 663 18 may may MD cord-016990-ot1wi3xi 663 19 be be VB cord-016990-ot1wi3xi 663 20 seen see VBN cord-016990-ot1wi3xi 663 21 in in IN cord-016990-ot1wi3xi 663 22 association association NN cord-016990-ot1wi3xi 663 23 with with IN cord-016990-ot1wi3xi 663 24 an an DT cord-016990-ot1wi3xi 663 25 interstitial interstitial JJ cord-016990-ot1wi3xi 663 26 pneumonitis pneumonitis NN cord-016990-ot1wi3xi 663 27 and and CC cord-016990-ot1wi3xi 663 28 organizing organizing NN cord-016990-ot1wi3xi 663 29 changes change NNS cord-016990-ot1wi3xi 663 30 ( ( -LRB- cord-016990-ot1wi3xi 663 31 Fig Fig NNP cord-016990-ot1wi3xi 663 32 . . . cord-016990-ot1wi3xi 664 1 11.12A 11.12a CD cord-016990-ot1wi3xi 664 2 , , , cord-016990-ot1wi3xi 664 3 B B NNP cord-016990-ot1wi3xi 664 4 ) ) -RRB- cord-016990-ot1wi3xi 664 5 . . . cord-016990-ot1wi3xi 665 1 239,240.249,255 239,240.249,255 CD cord-016990-ot1wi3xi 665 2 - - SYM cord-016990-ot1wi3xi 665 3 260 260 CD cord-016990-ot1wi3xi 666 1 These these DT cord-016990-ot1wi3xi 666 2 giant giant JJ cord-016990-ot1wi3xi 666 3 cells cell NNS cord-016990-ot1wi3xi 666 4 , , , cord-016990-ot1wi3xi 666 5 which which WDT cord-016990-ot1wi3xi 666 6 may may MD cord-016990-ot1wi3xi 666 7 contain contain VB cord-016990-ot1wi3xi 666 8 intracytoplasmic intracytoplasmic JJ cord-016990-ot1wi3xi 666 9 eosinophilic eosinophilic JJ cord-016990-ot1wi3xi 666 10 inclusions inclusion NNS cord-016990-ot1wi3xi 666 11 , , , cord-016990-ot1wi3xi 666 12 ( ( -LRB- cord-016990-ot1wi3xi 666 13 Fig Fig NNP cord-016990-ot1wi3xi 666 14 . . . cord-016990-ot1wi3xi 666 15 11.12C 11.12c CD cord-016990-ot1wi3xi 666 16 ) ) -RRB- cord-016990-ot1wi3xi 666 17 , , , cord-016990-ot1wi3xi 666 18 have have VBP cord-016990-ot1wi3xi 666 19 also also RB cord-016990-ot1wi3xi 666 20 been be VBN cord-016990-ot1wi3xi 666 21 reported report VBN cord-016990-ot1wi3xi 666 22 in in IN cord-016990-ot1wi3xi 666 23 extrapulmonary extrapulmonary JJ cord-016990-ot1wi3xi 666 24 tissues tissue NNS cord-016990-ot1wi3xi 666 25 such such JJ cord-016990-ot1wi3xi 666 26 as as IN cord-016990-ot1wi3xi 666 27 kidney kidney NN cord-016990-ot1wi3xi 666 28 , , , cord-016990-ot1wi3xi 666 29 bladder bladder NN cord-016990-ot1wi3xi 666 30 , , , cord-016990-ot1wi3xi 666 31 and and CC cord-016990-ot1wi3xi 666 32 pancreas pancreas NN cord-016990-ot1wi3xi 666 33 . . . cord-016990-ot1wi3xi 667 1 258 258 CD cord-016990-ot1wi3xi 667 2 Other other JJ cord-016990-ot1wi3xi 667 3 viral viral JJ cord-016990-ot1wi3xi 667 4 causes cause NNS cord-016990-ot1wi3xi 667 5 of of IN cord-016990-ot1wi3xi 667 6 giant giant JJ cord-016990-ot1wi3xi 667 7 cell cell NN cord-016990-ot1wi3xi 667 8 pneumonia pneumonia NN cord-016990-ot1wi3xi 667 9 , , , cord-016990-ot1wi3xi 667 10 including include VBG cord-016990-ot1wi3xi 667 11 measks measks NNP cord-016990-ot1wi3xi 667 12 , , , cord-016990-ot1wi3xi 667 13 RSV RSV NNP cord-016990-ot1wi3xi 667 14 , , , cord-016990-ot1wi3xi 667 15 VZV VZV NNP cord-016990-ot1wi3xi 667 16 , , , cord-016990-ot1wi3xi 667 17 and and CC cord-016990-ot1wi3xi 667 18 HSV HSV NNP cord-016990-ot1wi3xi 667 19 , , , cord-016990-ot1wi3xi 667 20 should should MD cord-016990-ot1wi3xi 667 21 be be VB cord-016990-ot1wi3xi 667 22 considered consider VBN cord-016990-ot1wi3xi 667 23 in in IN cord-016990-ot1wi3xi 667 24 the the DT cord-016990-ot1wi3xi 667 25 histopathologic histopathologic JJ cord-016990-ot1wi3xi 667 26 differential differential NN cord-016990-ot1wi3xi 667 27 and and CC cord-016990-ot1wi3xi 667 28 laboratory laboratory NN cord-016990-ot1wi3xi 667 29 testing testing NN cord-016990-ot1wi3xi 667 30 , , , cord-016990-ot1wi3xi 667 31 including include VBG cord-016990-ot1wi3xi 667 32 IHe ihe NN cord-016990-ot1wi3xi 667 33 , , , cord-016990-ot1wi3xi 667 34 can can MD cord-016990-ot1wi3xi 667 35 be be VB cord-016990-ot1wi3xi 667 36 useful useful JJ cord-016990-ot1wi3xi 667 37 in in IN cord-016990-ot1wi3xi 667 38 making make VBG cord-016990-ot1wi3xi 667 39 this this DT cord-016990-ot1wi3xi 667 40 differentiation differentiation NN cord-016990-ot1wi3xi 667 41 possible possible JJ cord-016990-ot1wi3xi 667 42 ( ( -LRB- cord-016990-ot1wi3xi 667 43 Fig Fig NNP cord-016990-ot1wi3xi 667 44 . . . cord-016990-ot1wi3xi 667 45 11.12D 11.12d CD cord-016990-ot1wi3xi 667 46 ) ) -RRB- cord-016990-ot1wi3xi 667 47 . . . cord-016990-ot1wi3xi 668 1 Diagnosis diagnosis NN cord-016990-ot1wi3xi 668 2 of of IN cord-016990-ot1wi3xi 668 3 infection infection NN cord-016990-ot1wi3xi 668 4 with with IN cord-016990-ot1wi3xi 668 5 HPIV HPIV NNP cord-016990-ot1wi3xi 668 6 scan scan NNP cord-016990-ot1wi3xi 668 7 also also RB cord-016990-ot1wi3xi 668 8 be be VB cord-016990-ot1wi3xi 668 9 made make VBN cord-016990-ot1wi3xi 668 10 by by IN cord-016990-ot1wi3xi 668 11 virus virus NN cord-016990-ot1wi3xi 668 12 isolation isolation NN cord-016990-ot1wi3xi 668 13 , , , cord-016990-ot1wi3xi 668 14 direct direct JJ cord-016990-ot1wi3xi 668 15 detection detection NN cord-016990-ot1wi3xi 668 16 of of IN cord-016990-ot1wi3xi 668 17 viral viral JJ cord-016990-ot1wi3xi 668 18 antigens antigen NNS cord-016990-ot1wi3xi 668 19 py py NN cord-016990-ot1wi3xi 668 20 enzyme enzyme NN cord-016990-ot1wi3xi 668 21 - - HYPH cord-016990-ot1wi3xi 668 22 linked link VBN cord-016990-ot1wi3xi 668 23 immunoassay immunoassay NN cord-016990-ot1wi3xi 668 24 ( ( -LRB- cord-016990-ot1wi3xi 668 25 EIA EIA NNP cord-016990-ot1wi3xi 668 26 ) ) -RRB- cord-016990-ot1wi3xi 668 27 or or CC cord-016990-ot1wi3xi 668 28 immunofluorescent immunofluorescent JJ cord-016990-ot1wi3xi 668 29 assay assay NN cord-016990-ot1wi3xi 668 30 ( ( -LRB- cord-016990-ot1wi3xi 668 31 IFA IFA NNP cord-016990-ot1wi3xi 668 32 ) ) -RRB- cord-016990-ot1wi3xi 668 33 in in IN cord-016990-ot1wi3xi 668 34 clinical clinical JJ cord-016990-ot1wi3xi 668 35 specimens specimen NNS cord-016990-ot1wi3xi 668 36 , , , cord-016990-ot1wi3xi 668 37 detection detection NN cord-016990-ot1wi3xi 668 38 of of IN cord-016990-ot1wi3xi 668 39 viral viral JJ cord-016990-ot1wi3xi 668 40 RNA RNA NNP cord-016990-ot1wi3xi 668 41 by by IN cord-016990-ot1wi3xi 668 42 RT RT NNP cord-016990-ot1wi3xi 668 43 - - HYPH cord-016990-ot1wi3xi 668 44 PCR PCR NNP cord-016990-ot1wi3xi 668 45 , , , cord-016990-ot1wi3xi 668 46 demonstration demonstration NN cord-016990-ot1wi3xi 668 47 of of IN cord-016990-ot1wi3xi 668 48 a a DT cord-016990-ot1wi3xi 668 49 rise rise NN cord-016990-ot1wi3xi 668 50 in in IN cord-016990-ot1wi3xi 668 51 _SP cord-016990-ot1wi3xi 668 52 Respiratory respiratory JJ cord-016990-ot1wi3xi 668 53 syncytial syncytial JJ cord-016990-ot1wi3xi 668 54 virus virus NN cord-016990-ot1wi3xi 668 55 ( ( -LRB- cord-016990-ot1wi3xi 668 56 RSV RSV NNP cord-016990-ot1wi3xi 668 57 ) ) -RRB- cord-016990-ot1wi3xi 669 1 is be VBZ cord-016990-ot1wi3xi 669 2 the the DT cord-016990-ot1wi3xi 669 3 most most RBS cord-016990-ot1wi3xi 669 4 common common JJ cord-016990-ot1wi3xi 669 5 cause cause NN cord-016990-ot1wi3xi 669 6 of of IN cord-016990-ot1wi3xi 669 7 bronchiolitis bronchiolitis NN cord-016990-ot1wi3xi 669 8 and and CC cord-016990-ot1wi3xi 669 9 pneumonia pneumonia NN cord-016990-ot1wi3xi 669 10 among among IN cord-016990-ot1wi3xi 669 11 infants infant NNS cord-016990-ot1wi3xi 669 12 and and CC cord-016990-ot1wi3xi 669 13 children child NNS cord-016990-ot1wi3xi 669 14 under under IN cord-016990-ot1wi3xi 669 15 1 1 CD cord-016990-ot1wi3xi 669 16 year year NN cord-016990-ot1wi3xi 669 17 of of IN cord-016990-ot1wi3xi 669 18 age age NN cord-016990-ot1wi3xi 669 19 . . . cord-016990-ot1wi3xi 670 1 The the DT cord-016990-ot1wi3xi 670 2 causative causative JJ cord-016990-ot1wi3xi 670 3 agent agent NN cord-016990-ot1wi3xi 670 4 is be VBZ cord-016990-ot1wi3xi 670 5 a a DT cord-016990-ot1wi3xi 670 6 negative negative JJ cord-016990-ot1wi3xi 670 7 - - HYPH cord-016990-ot1wi3xi 670 8 sense sense NN cord-016990-ot1wi3xi 670 9 , , , cord-016990-ot1wi3xi 670 10 nonsegmented nonsegmente VBN cord-016990-ot1wi3xi 670 11 , , , cord-016990-ot1wi3xi 670 12 single single RB cord-016990-ot1wi3xi 670 13 - - HYPH cord-016990-ot1wi3xi 670 14 stranded stranded JJ cord-016990-ot1wi3xi 670 15 , , , cord-016990-ot1wi3xi 670 16 enveloped envelop VBD cord-016990-ot1wi3xi 670 17 RNA RNA NNP cord-016990-ot1wi3xi 670 18 virus virus NN cord-016990-ot1wi3xi 670 19 . . . cord-016990-ot1wi3xi 671 1 The the DT cord-016990-ot1wi3xi 671 2 virion virion NN cord-016990-ot1wi3xi 671 3 is be VBZ cord-016990-ot1wi3xi 671 4 variable variable JJ cord-016990-ot1wi3xi 671 5 in in IN cord-016990-ot1wi3xi 671 6 shape shape NN cord-016990-ot1wi3xi 671 7 and and CC cord-016990-ot1wi3xi 671 8 size size NN cord-016990-ot1wi3xi 671 9 and and CC cord-016990-ot1wi3xi 671 10 ranges range VBZ cord-016990-ot1wi3xi 671 11 from from IN cord-016990-ot1wi3xi 671 12 120 120 CD cord-016990-ot1wi3xi 671 13 to to TO cord-016990-ot1wi3xi 671 14 300 300 CD cord-016990-ot1wi3xi 671 15 nm nm NN cord-016990-ot1wi3xi 671 16 . . . cord-016990-ot1wi3xi 672 1 Respiratory respiratory JJ cord-016990-ot1wi3xi 672 2 syncytial syncytial JJ cord-016990-ot1wi3xi 672 3 virus virus NN cord-016990-ot1wi3xi 672 4 is be VBZ cord-016990-ot1wi3xi 672 5 a a DT cord-016990-ot1wi3xi 672 6 member member NN cord-016990-ot1wi3xi 672 7 of of IN cord-016990-ot1wi3xi 672 8 the the DT cord-016990-ot1wi3xi 672 9 family family NN cord-016990-ot1wi3xi 672 10 Paramyxoviridae Paramyxoviridae NNP cord-016990-ot1wi3xi 672 11 , , , cord-016990-ot1wi3xi 672 12 subfamily subfamily NN cord-016990-ot1wi3xi 672 13 Pneumovirinae Pneumovirinae NNP cord-016990-ot1wi3xi 672 14 , , , cord-016990-ot1wi3xi 672 15 in in IN cord-016990-ot1wi3xi 672 16 the the DT cord-016990-ot1wi3xi 672 17 genus genus NN cord-016990-ot1wi3xi 672 18 Pneumovirus Pneumovirus NNP cord-016990-ot1wi3xi 672 19 , , , cord-016990-ot1wi3xi 672 20 and and CC cord-016990-ot1wi3xi 672 21 can can MD cord-016990-ot1wi3xi 672 22 be be VB cord-016990-ot1wi3xi 672 23 453 453 CD cord-016990-ot1wi3xi 672 24 ing e VBG cord-016990-ot1wi3xi 672 25 poorly poorly RB cord-016990-ot1wi3xi 672 26 defined define VBN cord-016990-ot1wi3xi 672 27 cytoplasmic cytoplasmic JJ cord-016990-ot1wi3xi 672 28 eosinophilic eosinophilic JJ cord-016990-ot1wi3xi 672 29 inclusions inclusion NNS cord-016990-ot1wi3xi 672 30 . . . cord-016990-ot1wi3xi 673 1 D. D. NNP cord-016990-ot1wi3xi 673 2 Parainfluenza Parainfluenza NNP cord-016990-ot1wi3xi 673 3 virus virus NN cord-016990-ot1wi3xi 673 4 antigens antigen NNS cord-016990-ot1wi3xi 673 5 in in IN cord-016990-ot1wi3xi 673 6 giant giant JJ cord-016990-ot1wi3xi 673 7 cells cell NNS cord-016990-ot1wi3xi 673 8 localized localize VBN cord-016990-ot1wi3xi 673 9 by by IN cord-016990-ot1wi3xi 673 10 using use VBG cord-016990-ot1wi3xi 673 11 immunohistochemistry immunohistochemistry NN cord-016990-ot1wi3xi 673 12 . . . cord-016990-ot1wi3xi 674 1 A a LS cord-016990-ot1wi3xi 674 2 - - HYPH cord-016990-ot1wi3xi 674 3 C C NNP cord-016990-ot1wi3xi 674 4 , , , cord-016990-ot1wi3xi 674 5 H&E H&E NNP cord-016990-ot1wi3xi 674 6 ; ; : cord-016990-ot1wi3xi 674 7 D D NNP cord-016990-ot1wi3xi 674 8 , , , cord-016990-ot1wi3xi 674 9 immunoalkaline immunoalkaline JJ cord-016990-ot1wi3xi 674 10 phosphatase phosphatase NN cord-016990-ot1wi3xi 674 11 staining staining NN cord-016990-ot1wi3xi 674 12 , , , cord-016990-ot1wi3xi 674 13 naphthol naphthol NNP cord-016990-ot1wi3xi 674 14 fast fast JJ cord-016990-ot1wi3xi 674 15 - - HYPH cord-016990-ot1wi3xi 674 16 red red NN cord-016990-ot1wi3xi 674 17 , , , cord-016990-ot1wi3xi 674 18 and and CC cord-016990-ot1wi3xi 674 19 hematoxylin hematoxylin NNP cord-016990-ot1wi3xi 674 20 counterstain counterstain NNP cord-016990-ot1wi3xi 674 21 . . . cord-016990-ot1wi3xi 675 1 further further RB cord-016990-ot1wi3xi 675 2 distinguished distinguish VBN cord-016990-ot1wi3xi 675 3 genetically genetically RB cord-016990-ot1wi3xi 675 4 and and CC cord-016990-ot1wi3xi 675 5 antigenically antigenically RB cord-016990-ot1wi3xi 675 6 into into IN cord-016990-ot1wi3xi 675 7 two two CD cord-016990-ot1wi3xi 675 8 subgroups subgroup NNS cord-016990-ot1wi3xi 675 9 , , , cord-016990-ot1wi3xi 675 10 A A NNP cord-016990-ot1wi3xi 675 11 and and CC cord-016990-ot1wi3xi 676 1 B. B. NNP cord-016990-ot1wi3xi 676 2 The the DT cord-016990-ot1wi3xi 676 3 subgroup subgroup NN cord-016990-ot1wi3xi 676 4 A a DT cord-016990-ot1wi3xi 676 5 strains strain NNS cord-016990-ot1wi3xi 676 6 are be VBP cord-016990-ot1wi3xi 676 7 usually usually RB cord-016990-ot1wi3xi 676 8 associated associate VBN cord-016990-ot1wi3xi 676 9 with with IN cord-016990-ot1wi3xi 676 10 more more JJR cord-016990-ot1wi3xi 676 11 severe severe JJ cord-016990-ot1wi3xi 676 12 infections infection NNS cord-016990-ot1wi3xi 676 13 . . . cord-016990-ot1wi3xi 677 1 Two two CD cord-016990-ot1wi3xi 677 2 surface surface NN cord-016990-ot1wi3xi 677 3 glycoproteins glycoprotein NNS cord-016990-ot1wi3xi 677 4 , , , cord-016990-ot1wi3xi 677 5 G G NNP cord-016990-ot1wi3xi 677 6 and and CC cord-016990-ot1wi3xi 677 7 F F NNP cord-016990-ot1wi3xi 677 8 , , , cord-016990-ot1wi3xi 677 9 are be VBP cord-016990-ot1wi3xi 677 10 present present JJ cord-016990-ot1wi3xi 677 11 in in IN cord-016990-ot1wi3xi 677 12 the the DT cord-016990-ot1wi3xi 677 13 envelope envelope NN cord-016990-ot1wi3xi 677 14 and and CC cord-016990-ot1wi3xi 677 15 mediate mediate VB cord-016990-ot1wi3xi 677 16 attachment attachment NN cord-016990-ot1wi3xi 677 17 and and CC cord-016990-ot1wi3xi 677 18 fusion fusion NN cord-016990-ot1wi3xi 677 19 with with IN cord-016990-ot1wi3xi 677 20 respiratory respiratory JJ cord-016990-ot1wi3xi 677 21 epithelium epithelium NN cord-016990-ot1wi3xi 677 22 . . . cord-016990-ot1wi3xi 678 1 The the DT cord-016990-ot1wi3xi 678 2 F F NNP cord-016990-ot1wi3xi 678 3 protein protein NN cord-016990-ot1wi3xi 678 4 also also RB cord-016990-ot1wi3xi 678 5 mediates mediate VBZ cord-016990-ot1wi3xi 678 6 coalescence coalescence NN cord-016990-ot1wi3xi 678 7 of of IN cord-016990-ot1wi3xi 678 8 neighboring neighboring NN cord-016990-ot1wi3xi 678 9 cells cell NNS cord-016990-ot1wi3xi 678 10 to to TO cord-016990-ot1wi3xi 678 11 form form VB cord-016990-ot1wi3xi 678 12 the the DT cord-016990-ot1wi3xi 678 13 characteristic characteristic JJ cord-016990-ot1wi3xi 678 14 multinucleated multinucleate VBN cord-016990-ot1wi3xi 678 15 syncytial syncytial JJ cord-016990-ot1wi3xi 678 16 giant giant JJ cord-016990-ot1wi3xi 678 17 cells cell NNS cord-016990-ot1wi3xi 678 18 for for IN cord-016990-ot1wi3xi 678 19 which which WDT cord-016990-ot1wi3xi 678 20 the the DT cord-016990-ot1wi3xi 678 21 virus virus NN cord-016990-ot1wi3xi 678 22 name name NN cord-016990-ot1wi3xi 678 23 is be VBZ cord-016990-ot1wi3xi 678 24 derived derive VBN cord-016990-ot1wi3xi 678 25 . . . cord-016990-ot1wi3xi 679 1 265 265 CD cord-016990-ot1wi3xi 679 2 Respiratory respiratory JJ cord-016990-ot1wi3xi 679 3 syncytial syncytial JJ cord-016990-ot1wi3xi 679 4 virus virus NN cord-016990-ot1wi3xi 679 5 is be VBZ cord-016990-ot1wi3xi 679 6 spread spread VBN cord-016990-ot1wi3xi 679 7 from from IN cord-016990-ot1wi3xi 679 8 respiratory respiratory JJ cord-016990-ot1wi3xi 679 9 secretions secretion NNS cord-016990-ot1wi3xi 679 10 through through IN cord-016990-ot1wi3xi 679 11 close close JJ cord-016990-ot1wi3xi 679 12 contact contact NN cord-016990-ot1wi3xi 679 13 with with IN cord-016990-ot1wi3xi 679 14 infected infected JJ cord-016990-ot1wi3xi 679 15 persons person NNS cord-016990-ot1wi3xi 679 16 or or CC cord-016990-ot1wi3xi 679 17 contact contact NN cord-016990-ot1wi3xi 679 18 with with IN cord-016990-ot1wi3xi 679 19 contaminated contaminated JJ cord-016990-ot1wi3xi 679 20 surfaces surface NNS cord-016990-ot1wi3xi 679 21 or or CC cord-016990-ot1wi3xi 679 22 objects?66 objects?66 NNP cord-016990-ot1wi3xi 679 23 Infection infection NN cord-016990-ot1wi3xi 679 24 can can MD cord-016990-ot1wi3xi 679 25 occur occur VB cord-016990-ot1wi3xi 679 26 when when WRB cord-016990-ot1wi3xi 679 27 infectious infectious JJ cord-016990-ot1wi3xi 679 28 material material NN cord-016990-ot1wi3xi 679 29 contacts contact NNS cord-016990-ot1wi3xi 679 30 mucous mucous JJ cord-016990-ot1wi3xi 679 31 membranes membrane NNS cord-016990-ot1wi3xi 679 32 of of IN cord-016990-ot1wi3xi 679 33 the the DT cord-016990-ot1wi3xi 679 34 eyes eye NNS cord-016990-ot1wi3xi 679 35 , , , cord-016990-ot1wi3xi 679 36 mouth mouth NN cord-016990-ot1wi3xi 679 37 , , , cord-016990-ot1wi3xi 679 38 or or CC cord-016990-ot1wi3xi 679 39 nose nose NN cord-016990-ot1wi3xi 679 40 , , , cord-016990-ot1wi3xi 679 41 and and CC cord-016990-ot1wi3xi 679 42 possibly possibly RB cord-016990-ot1wi3xi 679 43 through through IN cord-016990-ot1wi3xi 679 44 the the DT cord-016990-ot1wi3xi 679 45 inhalation inhalation NN cord-016990-ot1wi3xi 679 46 of of IN cord-016990-ot1wi3xi 679 47 droplets droplet NNS cord-016990-ot1wi3xi 679 48 generated generate VBN cord-016990-ot1wi3xi 679 49 by by IN cord-016990-ot1wi3xi 679 50 a a DT cord-016990-ot1wi3xi 679 51 sneeze sneeze NN cord-016990-ot1wi3xi 679 52 or or CC cord-016990-ot1wi3xi 679 53 cough cough NN cord-016990-ot1wi3xi 679 54 . . . cord-016990-ot1wi3xi 680 1 Respiratory respiratory JJ cord-016990-ot1wi3xi 680 2 syncytial syncytial JJ cord-016990-ot1wi3xi 680 3 virus virus NN cord-016990-ot1wi3xi 680 4 is be VBZ cord-016990-ot1wi3xi 680 5 unstable unstable JJ cord-016990-ot1wi3xi 680 6 in in IN cord-016990-ot1wi3xi 680 7 the the DT cord-016990-ot1wi3xi 680 8 environment environment NN cord-016990-ot1wi3xi 680 9 , , , cord-016990-ot1wi3xi 680 10 surviving survive VBG cord-016990-ot1wi3xi 680 11 a a DT cord-016990-ot1wi3xi 680 12 few few JJ cord-016990-ot1wi3xi 680 13 hours hour NNS cord-016990-ot1wi3xi 680 14 on on IN cord-016990-ot1wi3xi 680 15 environmental environmental JJ cord-016990-ot1wi3xi 680 16 surfaces surface NNS cord-016990-ot1wi3xi 680 17 , , , cord-016990-ot1wi3xi 680 18 and and CC cord-016990-ot1wi3xi 680 19 is be VBZ cord-016990-ot1wi3xi 680 20 readily readily RB cord-016990-ot1wi3xi 680 21 inactivated inactivate VBN cord-016990-ot1wi3xi 680 22 with with IN cord-016990-ot1wi3xi 680 23 soap soap NN cord-016990-ot1wi3xi 680 24 and and CC cord-016990-ot1wi3xi 680 25 water water NN cord-016990-ot1wi3xi 680 26 . . . cord-016990-ot1wi3xi 681 1 In in IN cord-016990-ot1wi3xi 681 2 temperate temperate JJ cord-016990-ot1wi3xi 681 3 climates climate NNS cord-016990-ot1wi3xi 681 4 , , , cord-016990-ot1wi3xi 681 5 RSV RSV NNP cord-016990-ot1wi3xi 681 6 infections infection NNS cord-016990-ot1wi3xi 681 7 usually usually RB cord-016990-ot1wi3xi 681 8 occur occur VBP cord-016990-ot1wi3xi 681 9 during during IN cord-016990-ot1wi3xi 681 10 annual annual JJ cord-016990-ot1wi3xi 681 11 community community NN cord-016990-ot1wi3xi 681 12 outbreaks outbreak NNS cord-016990-ot1wi3xi 681 13 , , , cord-016990-ot1wi3xi 681 14 often often RB cord-016990-ot1wi3xi 681 15 lasting last VBG cord-016990-ot1wi3xi 681 16 several several JJ cord-016990-ot1wi3xi 681 17 months month NNS cord-016990-ot1wi3xi 681 18 , , , cord-016990-ot1wi3xi 681 19 during during IN cord-016990-ot1wi3xi 681 20 the the DT cord-016990-ot1wi3xi 681 21 late late JJ cord-016990-ot1wi3xi 681 22 fall fall NN cord-016990-ot1wi3xi 681 23 , , , cord-016990-ot1wi3xi 681 24 winter winter NN cord-016990-ot1wi3xi 681 25 , , , cord-016990-ot1wi3xi 681 26 or or CC cord-016990-ot1wi3xi 681 27 early early JJ cord-016990-ot1wi3xi 681 28 spring spring NN cord-016990-ot1wi3xi 681 29 months month NNS cord-016990-ot1wi3xi 681 30 . . . cord-016990-ot1wi3xi 682 1 The the DT cord-016990-ot1wi3xi 682 2 timing timing NN cord-016990-ot1wi3xi 682 3 and and CC cord-016990-ot1wi3xi 682 4 severity severity NN cord-016990-ot1wi3xi 682 5 of of IN cord-016990-ot1wi3xi 682 6 outbreaks outbreak NNS cord-016990-ot1wi3xi 682 7 in in IN cord-016990-ot1wi3xi 682 8 a a DT cord-016990-ot1wi3xi 682 9 community community NN cord-016990-ot1wi3xi 682 10 vary vary VBP cord-016990-ot1wi3xi 682 11 from from IN cord-016990-ot1wi3xi 682 12 year year NN cord-016990-ot1wi3xi 682 13 to to IN cord-016990-ot1wi3xi 682 14 year year NN cord-016990-ot1wi3xi 682 15 . . . cord-016990-ot1wi3xi 683 1 Respiratory respiratory JJ cord-016990-ot1wi3xi 683 2 syncytial syncytial JJ cord-016990-ot1wi3xi 683 3 virus virus NN cord-016990-ot1wi3xi 683 4 spreads spread VBZ cord-016990-ot1wi3xi 683 5 efficiently efficiently RB cord-016990-ot1wi3xi 683 6 among among IN cord-016990-ot1wi3xi 683 7 children child NNS cord-016990-ot1wi3xi 683 8 during during IN cord-016990-ot1wi3xi 683 9 the the DT cord-016990-ot1wi3xi 683 10 annual annual JJ cord-016990-ot1wi3xi 683 11 outbreaks outbreak NNS cord-016990-ot1wi3xi 683 12 , , , cord-016990-ot1wi3xi 683 13 and and CC cord-016990-ot1wi3xi 683 14 most most JJS cord-016990-ot1wi3xi 683 15 children child NNS cord-016990-ot1wi3xi 683 16 will will MD cord-016990-ot1wi3xi 683 17 have have VB cord-016990-ot1wi3xi 683 18 serologic serologic JJ cord-016990-ot1wi3xi 683 19 evidence evidence NN cord-016990-ot1wi3xi 683 20 of of IN cord-016990-ot1wi3xi 683 21 RSV RSV NNP cord-016990-ot1wi3xi 683 22 infection infection NN cord-016990-ot1wi3xi 683 23 by by IN cord-016990-ot1wi3xi 683 24 2 2 CD cord-016990-ot1wi3xi 683 25 years year NNS cord-016990-ot1wi3xi 683 26 of of IN cord-016990-ot1wi3xi 683 27 age age NN cord-016990-ot1wi3xi 683 28 . . . cord-016990-ot1wi3xi 684 1 Illness illness NN cord-016990-ot1wi3xi 684 2 begins begin VBZ cord-016990-ot1wi3xi 684 3 most most RBS cord-016990-ot1wi3xi 684 4 frequently frequently RB cord-016990-ot1wi3xi 684 5 with with IN cord-016990-ot1wi3xi 684 6 fever fever NN cord-016990-ot1wi3xi 684 7 , , , cord-016990-ot1wi3xi 684 8 runny runny JJ cord-016990-ot1wi3xi 684 9 nose nose NN cord-016990-ot1wi3xi 684 10 , , , cord-016990-ot1wi3xi 684 11 cough cough NN cord-016990-ot1wi3xi 684 12 , , , cord-016990-ot1wi3xi 684 13 and and CC cord-016990-ot1wi3xi 684 14 sometimes sometimes RB cord-016990-ot1wi3xi 684 15 wheezing wheeze VBG cord-016990-ot1wi3xi 684 16 . . . cord-016990-ot1wi3xi 685 1 During during IN cord-016990-ot1wi3xi 685 2 their -PRON- PRP$ cord-016990-ot1wi3xi 685 3 first first JJ cord-016990-ot1wi3xi 685 4 RSV RSV NNP cord-016990-ot1wi3xi 685 5 infection infection NN cord-016990-ot1wi3xi 685 6 , , , cord-016990-ot1wi3xi 685 7 between between IN cord-016990-ot1wi3xi 685 8 25 25 CD cord-016990-ot1wi3xi 685 9 % % NN cord-016990-ot1wi3xi 685 10 and and CC cord-016990-ot1wi3xi 685 11 40 40 CD cord-016990-ot1wi3xi 685 12 % % NN cord-016990-ot1wi3xi 685 13 of of IN cord-016990-ot1wi3xi 685 14 infants infant NNS cord-016990-ot1wi3xi 685 15 and and CC cord-016990-ot1wi3xi 685 16 young young JJ cord-016990-ot1wi3xi 685 17 children child NNS cord-016990-ot1wi3xi 685 18 have have VBP cord-016990-ot1wi3xi 685 19 signs sign NNS cord-016990-ot1wi3xi 685 20 or or CC cord-016990-ot1wi3xi 685 21 symptoms symptom NNS cord-016990-ot1wi3xi 685 22 of of IN cord-016990-ot1wi3xi 685 23 bronchiolitis bronchiolitis NN cord-016990-ot1wi3xi 685 24 or or CC cord-016990-ot1wi3xi 685 25 pneumonia pneumonia NN cord-016990-ot1wi3xi 685 26 , , , cord-016990-ot1wi3xi 685 27 and and CC cord-016990-ot1wi3xi 685 28 0.5 0.5 CD cord-016990-ot1wi3xi 685 29 % % NN cord-016990-ot1wi3xi 685 30 to to TO cord-016990-ot1wi3xi 685 31 2 2 CD cord-016990-ot1wi3xi 685 32 % % NN cord-016990-ot1wi3xi 685 33 require require VBP cord-016990-ot1wi3xi 685 34 hospitalization hospitalization NN cord-016990-ot1wi3xi 685 35 . . . cord-016990-ot1wi3xi 686 1 Most Most JJS cord-016990-ot1wi3xi 686 2 children child NNS cord-016990-ot1wi3xi 686 3 recover recover VBP cord-016990-ot1wi3xi 686 4 from from IN cord-016990-ot1wi3xi 686 5 illness illness NN cord-016990-ot1wi3xi 686 6 in in IN cord-016990-ot1wi3xi 686 7 8 8 CD cord-016990-ot1wi3xi 686 8 to to TO cord-016990-ot1wi3xi 686 9 15 15 CD cord-016990-ot1wi3xi 686 10 days day NNS cord-016990-ot1wi3xi 686 11 . . . cord-016990-ot1wi3xi 687 1 The the DT cord-016990-ot1wi3xi 687 2 majority majority NN cord-016990-ot1wi3xi 687 3 of of IN cord-016990-ot1wi3xi 687 4 children child NNS cord-016990-ot1wi3xi 687 5 hospitalized hospitalize VBN cord-016990-ot1wi3xi 687 6 for for IN cord-016990-ot1wi3xi 687 7 RSV RSV NNP cord-016990-ot1wi3xi 687 8 infection infection NN cord-016990-ot1wi3xi 687 9 are be VBP cord-016990-ot1wi3xi 687 10 under under IN cord-016990-ot1wi3xi 687 11 6 6 CD cord-016990-ot1wi3xi 687 12 months month NNS cord-016990-ot1wi3xi 687 13 of of IN cord-016990-ot1wi3xi 687 14 age age NN cord-016990-ot1wi3xi 687 15 . . . cord-016990-ot1wi3xi 688 1 Respiratory respiratory JJ cord-016990-ot1wi3xi 688 2 syncytial syncytial JJ cord-016990-ot1wi3xi 688 3 virus virus NN cord-016990-ot1wi3xi 688 4 also also RB cord-016990-ot1wi3xi 688 5 causes cause VBZ cord-016990-ot1wi3xi 688 6 repeated repeat VBN cord-016990-ot1wi3xi 688 7 infections infection NNS cord-016990-ot1wi3xi 688 8 throughout throughout IN cord-016990-ot1wi3xi 688 9 life life NN cord-016990-ot1wi3xi 688 10 , , , cord-016990-ot1wi3xi 688 11 usually usually RB cord-016990-ot1wi3xi 688 12 associated associate VBN cord-016990-ot1wi3xi 688 13 with with IN cord-016990-ot1wi3xi 688 14 moderate moderate JJ cord-016990-ot1wi3xi 688 15 - - HYPH cord-016990-ot1wi3xi 688 16 to to IN cord-016990-ot1wi3xi 688 17 - - HYPH cord-016990-ot1wi3xi 688 18 severe severe JJ cord-016990-ot1wi3xi 688 19 cold cold JJ cord-016990-ot1wi3xi 688 20 - - HYPH cord-016990-ot1wi3xi 688 21 like like JJ cord-016990-ot1wi3xi 688 22 symptoms symptom NNS cord-016990-ot1wi3xi 688 23 ; ; : cord-016990-ot1wi3xi 688 24 however however RB cord-016990-ot1wi3xi 688 25 , , , cord-016990-ot1wi3xi 688 26 severe severe JJ cord-016990-ot1wi3xi 688 27 lower low JJR cord-016990-ot1wi3xi 688 28 respiratory respiratory JJ cord-016990-ot1wi3xi 688 29 tract tract NN cord-016990-ot1wi3xi 688 30 disease disease NN cord-016990-ot1wi3xi 688 31 may may MD cord-016990-ot1wi3xi 688 32 occur occur VB cord-016990-ot1wi3xi 688 33 at at IN cord-016990-ot1wi3xi 688 34 any any DT cord-016990-ot1wi3xi 688 35 age age NN cord-016990-ot1wi3xi 688 36 , , , cord-016990-ot1wi3xi 688 37 especially especially RB cord-016990-ot1wi3xi 688 38 among among IN cord-016990-ot1wi3xi 688 39 the the DT cord-016990-ot1wi3xi 688 40 elderly elderly JJ cord-016990-ot1wi3xi 688 41 or or CC cord-016990-ot1wi3xi 688 42 among among IN cord-016990-ot1wi3xi 688 43 those those DT cord-016990-ot1wi3xi 688 44 with with IN cord-016990-ot1wi3xi 688 45 compromised compromised JJ cord-016990-ot1wi3xi 688 46 cardiac cardiac JJ cord-016990-ot1wi3xi 688 47 , , , cord-016990-ot1wi3xi 688 48 pulmonary pulmonary JJ cord-016990-ot1wi3xi 688 49 , , , cord-016990-ot1wi3xi 688 50 or or CC cord-016990-ot1wi3xi 688 51 immune immune JJ cord-016990-ot1wi3xi 688 52 systems system NNS cord-016990-ot1wi3xi 688 53 . . . cord-016990-ot1wi3xi 689 1 The the DT cord-016990-ot1wi3xi 689 2 major major JJ cord-016990-ot1wi3xi 689 3 histopathologic histopathologic JJ cord-016990-ot1wi3xi 689 4 changes change NNS cord-016990-ot1wi3xi 689 5 described describe VBN cord-016990-ot1wi3xi 689 6 in in IN cord-016990-ot1wi3xi 689 7 fatal fatal JJ cord-016990-ot1wi3xi 689 8 RSV RSV NNP cord-016990-ot1wi3xi 689 9 infections infection NNS cord-016990-ot1wi3xi 689 10 include include VBP cord-016990-ot1wi3xi 689 11 necrotizing necrotize VBG cord-016990-ot1wi3xi 689 12 bronchiolitis bronchiolitis NN cord-016990-ot1wi3xi 689 13 and and CC cord-016990-ot1wi3xi 689 14 interstitial interstitial JJ cord-016990-ot1wi3xi 689 15 pneumonia pneumonia NN cord-016990-ot1wi3xi 689 16 ( ( -LRB- cord-016990-ot1wi3xi 689 17 Fig Fig NNP cord-016990-ot1wi3xi 689 18 . . . cord-016990-ot1wi3xi 689 19 11.13A 11.13a CD cord-016990-ot1wi3xi 689 20 , , , cord-016990-ot1wi3xi 689 21 B b NN cord-016990-ot1wi3xi 689 22 ) ) -RRB- cord-016990-ot1wi3xi 689 23 .238,267 .238,267 . cord-016990-ot1wi3xi 689 24 - - : cord-016990-ot1wi3xi 689 25 272 272 CD cord-016990-ot1wi3xi 689 26 Bronchiallumina Bronchiallumina NNP cord-016990-ot1wi3xi 689 27 and and CC cord-016990-ot1wi3xi 689 28 airways airway NNS cord-016990-ot1wi3xi 689 29 are be VBP cord-016990-ot1wi3xi 689 30 usually usually RB cord-016990-ot1wi3xi 689 31 filled fill VBN cord-016990-ot1wi3xi 689 32 with with IN cord-016990-ot1wi3xi 689 33 necrotic necrotic JJ cord-016990-ot1wi3xi 689 34 debris debris NN cord-016990-ot1wi3xi 689 35 and and CC cord-016990-ot1wi3xi 689 36 inflammatory inflammatory JJ cord-016990-ot1wi3xi 689 37 cells cell NNS cord-016990-ot1wi3xi 689 38 . . . cord-016990-ot1wi3xi 690 1 These these DT cord-016990-ot1wi3xi 690 2 findings finding NNS cord-016990-ot1wi3xi 690 3 may may MD cord-016990-ot1wi3xi 690 4 be be VB cord-016990-ot1wi3xi 690 5 accompanied accompany VBN cord-016990-ot1wi3xi 690 6 by by IN cord-016990-ot1wi3xi 690 7 various various JJ cord-016990-ot1wi3xi 690 8 degrees degree NNS cord-016990-ot1wi3xi 690 9 of of IN cord-016990-ot1wi3xi 690 10 diffuse diffuse JJ cord-016990-ot1wi3xi 690 11 alveolar alveolar NN cord-016990-ot1wi3xi 690 12 damage damage NN cord-016990-ot1wi3xi 691 1 ( ( -LRB- cord-016990-ot1wi3xi 691 2 Fig Fig NNP cord-016990-ot1wi3xi 691 3 . . . cord-016990-ot1wi3xi 691 4 11.13E 11.13e CD cord-016990-ot1wi3xi 691 5 ) ) -RRB- cord-016990-ot1wi3xi 691 6 , , , cord-016990-ot1wi3xi 691 7 organizational organizational JJ cord-016990-ot1wi3xi 691 8 changes change NNS cord-016990-ot1wi3xi 691 9 , , , cord-016990-ot1wi3xi 691 10 and and CC cord-016990-ot1wi3xi 691 11 secondary secondary JJ cord-016990-ot1wi3xi 691 12 bacterial bacterial JJ cord-016990-ot1wi3xi 691 13 superinfection superinfection NN cord-016990-ot1wi3xi 691 14 . . . cord-016990-ot1wi3xi 692 1 Giant giant JJ cord-016990-ot1wi3xi 692 2 cell cell NN cord-016990-ot1wi3xi 692 3 pneumonia pneumonia NN cord-016990-ot1wi3xi 692 4 is be VBZ cord-016990-ot1wi3xi 692 5 a a DT cord-016990-ot1wi3xi 692 6 feature feature NN cord-016990-ot1wi3xi 692 7 seen see VBN cord-016990-ot1wi3xi 692 8 in in IN cord-016990-ot1wi3xi 692 9 some some DT cord-016990-ot1wi3xi 692 10 cases case NNS cord-016990-ot1wi3xi 692 11 ( ( -LRB- cord-016990-ot1wi3xi 692 12 Fig fig NN cord-016990-ot1wi3xi 692 13 . . . cord-016990-ot1wi3xi 693 1 11.13C 11.13c CD cord-016990-ot1wi3xi 693 2 , , , cord-016990-ot1wi3xi 693 3 D D NNP cord-016990-ot1wi3xi 693 4 ) ) -RRB- cord-016990-ot1wi3xi 693 5 . . . cord-016990-ot1wi3xi 694 1 The the DT cord-016990-ot1wi3xi 694 2 multinucleated multinucleated JJ cord-016990-ot1wi3xi 694 3 giant giant JJ cord-016990-ot1wi3xi 694 4 cells cell NNS cord-016990-ot1wi3xi 694 5 contain contain VBP cord-016990-ot1wi3xi 694 6 irregular irregular JJ cord-016990-ot1wi3xi 694 7 , , , cord-016990-ot1wi3xi 694 8 intracytoplasmic intracytoplasmic JJ cord-016990-ot1wi3xi 694 9 , , , cord-016990-ot1wi3xi 694 10 eosinophilic eosinophilic JJ cord-016990-ot1wi3xi 694 11 inclusions inclusion NNS cord-016990-ot1wi3xi 694 12 surrounded surround VBN cord-016990-ot1wi3xi 694 13 by by IN cord-016990-ot1wi3xi 694 14 a a DT cord-016990-ot1wi3xi 694 15 clear clear JJ cord-016990-ot1wi3xi 694 16 halo halo NN cord-016990-ot1wi3xi 694 17 . . . cord-016990-ot1wi3xi 695 1 These these DT cord-016990-ot1wi3xi 695 2 inclusions inclusion NNS cord-016990-ot1wi3xi 695 3 are be VBP cord-016990-ot1wi3xi 695 4 extremely extremely RB cord-016990-ot1wi3xi 695 5 difficult difficult JJ cord-016990-ot1wi3xi 695 6 to to TO cord-016990-ot1wi3xi 695 7 identify identify VB cord-016990-ot1wi3xi 695 8 with with IN cord-016990-ot1wi3xi 695 9 any any DT cord-016990-ot1wi3xi 695 10 degree degree NN cord-016990-ot1wi3xi 695 11 of of IN cord-016990-ot1wi3xi 695 12 certainty certainty NN cord-016990-ot1wi3xi 695 13 and and CC cord-016990-ot1wi3xi 695 14 are be VBP cord-016990-ot1wi3xi 695 15 only only RB cord-016990-ot1wi3xi 695 16 seen see VBN cord-016990-ot1wi3xi 695 17 in in IN cord-016990-ot1wi3xi 695 18 about about IN cord-016990-ot1wi3xi 695 19 half half PDT cord-016990-ot1wi3xi 695 20 the the DT cord-016990-ot1wi3xi 695 21 cases case NNS cord-016990-ot1wi3xi 695 22 ( ( -LRB- cord-016990-ot1wi3xi 695 23 Fig Fig NNP cord-016990-ot1wi3xi 695 24 . . . cord-016990-ot1wi3xi 695 25 11.13D 11.13d CD cord-016990-ot1wi3xi 695 26 ) ) -RRB- cord-016990-ot1wi3xi 695 27 . . . cord-016990-ot1wi3xi 696 1 Other other JJ cord-016990-ot1wi3xi 696 2 viral viral JJ cord-016990-ot1wi3xi 696 3 causes cause NNS cord-016990-ot1wi3xi 696 4 of of IN cord-016990-ot1wi3xi 696 5 giant giant JJ cord-016990-ot1wi3xi 696 6 cell cell NN cord-016990-ot1wi3xi 696 7 pneumonia pneumonia NN cord-016990-ot1wi3xi 696 8 should should MD cord-016990-ot1wi3xi 696 9 be be VB cord-016990-ot1wi3xi 696 10 considered consider VBN cord-016990-ot1wi3xi 696 11 in in IN cord-016990-ot1wi3xi 696 12 the the DT cord-016990-ot1wi3xi 696 13 histopathologic histopathologic JJ cord-016990-ot1wi3xi 696 14 differential differential NN cord-016990-ot1wi3xi 696 15 and and CC cord-016990-ot1wi3xi 696 16 laboratory laboratory NN cord-016990-ot1wi3xi 696 17 testing testing NN cord-016990-ot1wi3xi 696 18 , , , cord-016990-ot1wi3xi 696 19 including include VBG cord-016990-ot1wi3xi 696 20 IHC,271,273,274 IHC,271,273,274 NNP cord-016990-ot1wi3xi 696 21 can can MD cord-016990-ot1wi3xi 696 22 be be VB cord-016990-ot1wi3xi 696 23 useful useful JJ cord-016990-ot1wi3xi 696 24 in in IN cord-016990-ot1wi3xi 696 25 making make VBG cord-016990-ot1wi3xi 696 26 this this DT cord-016990-ot1wi3xi 696 27 differentiation differentiation NN cord-016990-ot1wi3xi 696 28 possible possible JJ cord-016990-ot1wi3xi 696 29 ( ( -LRB- cord-016990-ot1wi3xi 696 30 Fig Fig NNP cord-016990-ot1wi3xi 696 31 . . . cord-016990-ot1wi3xi 696 32 11.13B 11.13b CD cord-016990-ot1wi3xi 696 33 , , , cord-016990-ot1wi3xi 696 34 F F NNP cord-016990-ot1wi3xi 696 35 ) ) -RRB- cord-016990-ot1wi3xi 696 36 . . . cord-016990-ot1wi3xi 697 1 Diagnosis diagnosis NN cord-016990-ot1wi3xi 697 2 of of IN cord-016990-ot1wi3xi 697 3 RSV RSV NNP cord-016990-ot1wi3xi 697 4 infection infection NN cord-016990-ot1wi3xi 697 5 can can MD cord-016990-ot1wi3xi 697 6 also also RB cord-016990-ot1wi3xi 697 7 be be VB cord-016990-ot1wi3xi 697 8 made make VBN cord-016990-ot1wi3xi 697 9 by by IN cord-016990-ot1wi3xi 697 10 virus virus NN cord-016990-ot1wi3xi 697 11 isolation isolation NN cord-016990-ot1wi3xi 697 12 , , , cord-016990-ot1wi3xi 697 13 direct direct JJ cord-016990-ot1wi3xi 697 14 detection detection NN cord-016990-ot1wi3xi 697 15 of of IN cord-016990-ot1wi3xi 697 16 viral viral JJ cord-016990-ot1wi3xi 697 17 antigens antigen NNS cord-016990-ot1wi3xi 697 18 in in IN cord-016990-ot1wi3xi 697 19 clinical clinical JJ cord-016990-ot1wi3xi 697 20 specimens specimen NNS cord-016990-ot1wi3xi 697 21 by by IN cord-016990-ot1wi3xi 697 22 EIA EIA NNP cord-016990-ot1wi3xi 697 23 or or CC cord-016990-ot1wi3xi 697 24 IFA IFA NNP cord-016990-ot1wi3xi 697 25 , , , cord-016990-ot1wi3xi 697 26 detection detection NN cord-016990-ot1wi3xi 697 27 of of IN cord-016990-ot1wi3xi 697 28 viral viral JJ cord-016990-ot1wi3xi 697 29 RNA RNA NNP cord-016990-ot1wi3xi 697 30 by by IN cord-016990-ot1wi3xi 697 31 RT RT NNP cord-016990-ot1wi3xi 697 32 - - HYPH cord-016990-ot1wi3xi 697 33 PCR PCR NNP cord-016990-ot1wi3xi 697 34 , , , cord-016990-ot1wi3xi 697 35 demonstration demonstration NN cord-016990-ot1wi3xi 697 36 of of IN cord-016990-ot1wi3xi 697 37 a a DT cord-016990-ot1wi3xi 697 38 rise rise NN cord-016990-ot1wi3xi 697 39 in in IN cord-016990-ot1wi3xi 697 40 RSVspecific rsvspecific NN cord-016990-ot1wi3xi 697 41 serum serum NN cord-016990-ot1wi3xi 697 42 antibodies antibody NNS cord-016990-ot1wi3xi 697 43 , , , cord-016990-ot1wi3xi 697 44 or or CC cord-016990-ot1wi3xi 697 45 a a DT cord-016990-ot1wi3xi 697 46 combination combination NN cord-016990-ot1wi3xi 697 47 of of IN cord-016990-ot1wi3xi 697 48 these these DT cord-016990-ot1wi3xi 697 49 approaches approach NNS cord-016990-ot1wi3xi 697 50 ( ( -LRB- cord-016990-ot1wi3xi 697 51 see see VB cord-016990-ot1wi3xi 697 52 also also RB cord-016990-ot1wi3xi 697 53 Fig Fig NNP cord-016990-ot1wi3xi 697 54 . . . cord-016990-ot1wi3xi 698 1 7.43 7.43 CD cord-016990-ot1wi3xi 698 2 , , , cord-016990-ot1wi3xi 698 3 Chapter chapter NN cord-016990-ot1wi3xi 698 4 7 7 CD cord-016990-ot1wi3xi 698 5 ) ) -RRB- cord-016990-ot1wi3xi 699 1 .264,275 .264,275 . cord-016990-ot1wi3xi 700 1 -281 -281 NNP cord-016990-ot1wi3xi 701 1 In in IN cord-016990-ot1wi3xi 701 2 2001 2001 CD cord-016990-ot1wi3xi 701 3 , , , cord-016990-ot1wi3xi 701 4 van van NNP cord-016990-ot1wi3xi 701 5 den den NNP cord-016990-ot1wi3xi 701 6 Hoogen Hoogen NNP cord-016990-ot1wi3xi 701 7 et et NNP cord-016990-ot1wi3xi 701 8 a1 a1 NNP cord-016990-ot1wi3xi 701 9 . . . cord-016990-ot1wi3xi 702 1 282 282 CD cord-016990-ot1wi3xi 702 2 described describe VBD cord-016990-ot1wi3xi 702 3 the the DT cord-016990-ot1wi3xi 702 4 identification identification NN cord-016990-ot1wi3xi 702 5 of of IN cord-016990-ot1wi3xi 702 6 this this DT cord-016990-ot1wi3xi 702 7 new new JJ cord-016990-ot1wi3xi 702 8 viral viral JJ cord-016990-ot1wi3xi 702 9 agent agent NN cord-016990-ot1wi3xi 702 10 from from IN cord-016990-ot1wi3xi 702 11 clinical clinical JJ cord-016990-ot1wi3xi 702 12 specimens specimen NNS cord-016990-ot1wi3xi 702 13 obtained obtain VBN cord-016990-ot1wi3xi 702 14 from from IN cord-016990-ot1wi3xi 702 15 patients patient NNS cord-016990-ot1wi3xi 702 16 with with IN cord-016990-ot1wi3xi 702 17 respiratory respiratory JJ cord-016990-ot1wi3xi 702 18 illness illness NN cord-016990-ot1wi3xi 702 19 , , , cord-016990-ot1wi3xi 702 20 which which WDT cord-016990-ot1wi3xi 702 21 455 455 CD cord-016990-ot1wi3xi 702 22 they -PRON- PRP cord-016990-ot1wi3xi 702 23 designated designate VBD cord-016990-ot1wi3xi 702 24 human human JJ cord-016990-ot1wi3xi 702 25 metapneumovirus metapneumovirus NNP cord-016990-ot1wi3xi 702 26 ( ( -LRB- cord-016990-ot1wi3xi 702 27 HMPV HMPV NNP cord-016990-ot1wi3xi 702 28 ) ) -RRB- cord-016990-ot1wi3xi 702 29 . . . cord-016990-ot1wi3xi 703 1 It -PRON- PRP cord-016990-ot1wi3xi 703 2 is be VBZ cord-016990-ot1wi3xi 703 3 a a DT cord-016990-ot1wi3xi 703 4 negative negative JJ cord-016990-ot1wi3xi 703 5 - - HYPH cord-016990-ot1wi3xi 703 6 sense sense NN cord-016990-ot1wi3xi 703 7 , , , cord-016990-ot1wi3xi 703 8 nonsegmented nonsegmente VBN cord-016990-ot1wi3xi 703 9 , , , cord-016990-ot1wi3xi 703 10 single single RB cord-016990-ot1wi3xi 703 11 - - HYPH cord-016990-ot1wi3xi 703 12 stranded stranded JJ cord-016990-ot1wi3xi 703 13 , , , cord-016990-ot1wi3xi 703 14 enveloped envelop VBD cord-016990-ot1wi3xi 703 15 RNA RNA NNP cord-016990-ot1wi3xi 703 16 virus virus NN cord-016990-ot1wi3xi 703 17 . . . cord-016990-ot1wi3xi 704 1 The the DT cord-016990-ot1wi3xi 704 2 virion virion NN cord-016990-ot1wi3xi 704 3 is be VBZ cord-016990-ot1wi3xi 704 4 variable variable JJ cord-016990-ot1wi3xi 704 5 in in IN cord-016990-ot1wi3xi 704 6 shape shape NN cord-016990-ot1wi3xi 704 7 and and CC cord-016990-ot1wi3xi 704 8 size size NN cord-016990-ot1wi3xi 704 9 , , , cord-016990-ot1wi3xi 704 10 ranging range VBG cord-016990-ot1wi3xi 704 11 from from IN cord-016990-ot1wi3xi 704 12 150 150 CD cord-016990-ot1wi3xi 704 13 to to TO cord-016990-ot1wi3xi 704 14 300 300 CD cord-016990-ot1wi3xi 704 15 nm nm NN cord-016990-ot1wi3xi 704 16 ( ( -LRB- cord-016990-ot1wi3xi 704 17 Fig Fig NNP cord-016990-ot1wi3xi 704 18 . . . cord-016990-ot1wi3xi 704 19 11.1F 11.1f CD cord-016990-ot1wi3xi 704 20 ) ) -RRB- cord-016990-ot1wi3xi 704 21 . . . cord-016990-ot1wi3xi 705 1 It -PRON- PRP cord-016990-ot1wi3xi 705 2 has have VBZ cord-016990-ot1wi3xi 705 3 been be VBN cord-016990-ot1wi3xi 705 4 categorized categorize VBN cord-016990-ot1wi3xi 705 5 in in IN cord-016990-ot1wi3xi 705 6 the the DT cord-016990-ot1wi3xi 705 7 family family NN cord-016990-ot1wi3xi 705 8 Paramyxoviridae Paramyxoviridae NNP cord-016990-ot1wi3xi 705 9 , , , cord-016990-ot1wi3xi 705 10 subfamily subfamily NN cord-016990-ot1wi3xi 705 11 Pneumovirinae Pneumovirinae NNP cord-016990-ot1wi3xi 705 12 , , , cord-016990-ot1wi3xi 705 13 genus genus NN cord-016990-ot1wi3xi 705 14 Metapneumovirus Metapneumovirus NNP cord-016990-ot1wi3xi 705 15 , , , cord-016990-ot1wi3xi 705 16 based base VBN cord-016990-ot1wi3xi 705 17 on on IN cord-016990-ot1wi3xi 705 18 genomic genomic JJ cord-016990-ot1wi3xi 705 19 sequence sequence NN cord-016990-ot1wi3xi 705 20 and and CC cord-016990-ot1wi3xi 705 21 gene gene NN cord-016990-ot1wi3xi 705 22 constellation constellation NN cord-016990-ot1wi3xi 705 23 . . . cord-016990-ot1wi3xi 706 1 Human human JJ cord-016990-ot1wi3xi 706 2 metapneumovirus metapneumovirus NN cord-016990-ot1wi3xi 706 3 can can MD cord-016990-ot1wi3xi 706 4 be be VB cord-016990-ot1wi3xi 706 5 further further RB cord-016990-ot1wi3xi 706 6 distinguished distinguish VBN cord-016990-ot1wi3xi 706 7 genetically genetically RB cord-016990-ot1wi3xi 706 8 and and CC cord-016990-ot1wi3xi 706 9 antigenically antigenically RB cord-016990-ot1wi3xi 706 10 into into IN cord-016990-ot1wi3xi 706 11 two two CD cord-016990-ot1wi3xi 706 12 subgroups subgroup NNS cord-016990-ot1wi3xi 706 13 , , , cord-016990-ot1wi3xi 706 14 A A NNP cord-016990-ot1wi3xi 706 15 and and CC cord-016990-ot1wi3xi 706 16 B. B. NNP cord-016990-ot1wi3xi 706 17 Similar Similar NNP cord-016990-ot1wi3xi 706 18 to to IN cord-016990-ot1wi3xi 706 19 RSV RSV NNP cord-016990-ot1wi3xi 706 20 , , , cord-016990-ot1wi3xi 706 21 HMPV HMPV NNP cord-016990-ot1wi3xi 706 22 infection infection NN cord-016990-ot1wi3xi 706 23 is be VBZ cord-016990-ot1wi3xi 706 24 ubiquitous ubiquitous JJ cord-016990-ot1wi3xi 706 25 and and CC cord-016990-ot1wi3xi 706 26 occurs occur VBZ cord-016990-ot1wi3xi 706 27 during during IN cord-016990-ot1wi3xi 706 28 infancy infancy NN cord-016990-ot1wi3xi 706 29 and and CC cord-016990-ot1wi3xi 706 30 early early JJ cord-016990-ot1wi3xi 706 31 childhood childhood NN cord-016990-ot1wi3xi 706 32 , , , cord-016990-ot1wi3xi 706 33 with with IN cord-016990-ot1wi3xi 706 34 annual annual JJ cord-016990-ot1wi3xi 706 35 epidemic epidemic NN cord-016990-ot1wi3xi 706 36 peaks peak NNS cord-016990-ot1wi3xi 706 37 occurring occur VBG cord-016990-ot1wi3xi 706 38 in in IN cord-016990-ot1wi3xi 706 39 the the DT cord-016990-ot1wi3xi 706 40 winter winter NN cord-016990-ot1wi3xi 706 41 and and CC cord-016990-ot1wi3xi 706 42 spring spring NN cord-016990-ot1wi3xi 706 43 months month NNS cord-016990-ot1wi3xi 706 44 in in IN cord-016990-ot1wi3xi 706 45 temperate temperate JJ cord-016990-ot1wi3xi 706 46 regions region NNS cord-016990-ot1wi3xi 706 47 . . . cord-016990-ot1wi3xi 707 1 Seroprevalence Seroprevalence NNP cord-016990-ot1wi3xi 707 2 studies study NNS cord-016990-ot1wi3xi 707 3 reveal reveal VBP cord-016990-ot1wi3xi 707 4 that that IN cord-016990-ot1wi3xi 707 5 25 25 CD cord-016990-ot1wi3xi 707 6 % % NN cord-016990-ot1wi3xi 707 7 of of IN cord-016990-ot1wi3xi 707 8 all all DT cord-016990-ot1wi3xi 707 9 children child NNS cord-016990-ot1wi3xi 707 10 aged age VBN cord-016990-ot1wi3xi 707 11 6 6 CD cord-016990-ot1wi3xi 707 12 to to TO cord-016990-ot1wi3xi 707 13 12 12 CD cord-016990-ot1wi3xi 707 14 months month NNS cord-016990-ot1wi3xi 707 15 have have VBP cord-016990-ot1wi3xi 707 16 antibodies antibody NNS cord-016990-ot1wi3xi 707 17 to to IN cord-016990-ot1wi3xi 707 18 HMPV HMPV NNP cord-016990-ot1wi3xi 707 19 ; ; : cord-016990-ot1wi3xi 707 20 by by IN cord-016990-ot1wi3xi 707 21 age age NN cord-016990-ot1wi3xi 707 22 5 5 CD cord-016990-ot1wi3xi 707 23 years year NNS cord-016990-ot1wi3xi 707 24 , , , cord-016990-ot1wi3xi 707 25 100 100 CD cord-016990-ot1wi3xi 707 26 % % NN cord-016990-ot1wi3xi 707 27 of of IN cord-016990-ot1wi3xi 707 28 patients patient NNS cord-016990-ot1wi3xi 707 29 have have VBP cord-016990-ot1wi3xi 707 30 evidence evidence NN cord-016990-ot1wi3xi 707 31 of of IN cord-016990-ot1wi3xi 707 32 past past JJ cord-016990-ot1wi3xi 707 33 infection infection NN cord-016990-ot1wi3xi 707 34 . . . cord-016990-ot1wi3xi 708 1 Like like IN cord-016990-ot1wi3xi 708 2 RSV RSV NNP cord-016990-ot1wi3xi 708 3 , , , cord-016990-ot1wi3xi 708 4 HMPV HMPV NNP cord-016990-ot1wi3xi 708 5 has have VBZ cord-016990-ot1wi3xi 708 6 been be VBN cord-016990-ot1wi3xi 708 7 associated associate VBN cord-016990-ot1wi3xi 708 8 with with IN cord-016990-ot1wi3xi 708 9 a a DT cord-016990-ot1wi3xi 708 10 wide wide JJ cord-016990-ot1wi3xi 708 11 spectrum spectrum NN cord-016990-ot1wi3xi 708 12 of of IN cord-016990-ot1wi3xi 708 13 respiratory respiratory JJ cord-016990-ot1wi3xi 708 14 illnesses.283 illnesses.283 NNP cord-016990-ot1wi3xi 708 15 - - HYPH cord-016990-ot1wi3xi 708 16 287 287 CD cord-016990-ot1wi3xi 708 17 The the DT cord-016990-ot1wi3xi 708 18 patient patient NN cord-016990-ot1wi3xi 708 19 may may MD cord-016990-ot1wi3xi 708 20 be be VB cord-016990-ot1wi3xi 708 21 asymptomatic asymptomatic JJ cord-016990-ot1wi3xi 708 22 , , , cord-016990-ot1wi3xi 708 23 or or CC cord-016990-ot1wi3xi 708 24 symptoms symptom NNS cord-016990-ot1wi3xi 708 25 may may MD cord-016990-ot1wi3xi 708 26 range range VB cord-016990-ot1wi3xi 708 27 from from IN cord-016990-ot1wi3xi 708 28 mild mild JJ cord-016990-ot1wi3xi 708 29 upper upper JJ cord-016990-ot1wi3xi 708 30 respiratory respiratory JJ cord-016990-ot1wi3xi 708 31 tract tract NN cord-016990-ot1wi3xi 708 32 illness illness NN cord-016990-ot1wi3xi 708 33 to to IN cord-016990-ot1wi3xi 708 34 severe severe JJ cord-016990-ot1wi3xi 708 35 bronchiolitis bronchiolitis NN cord-016990-ot1wi3xi 708 36 and and CC cord-016990-ot1wi3xi 708 37 pneumonia pneumonia NN cord-016990-ot1wi3xi 708 38 . . . cord-016990-ot1wi3xi 709 1 Although although IN cord-016990-ot1wi3xi 709 2 RSV RSV NNP cord-016990-ot1wi3xi 709 3 , , , cord-016990-ot1wi3xi 709 4 HPIV HPIV NNP cord-016990-ot1wi3xi 709 5 - - HYPH cord-016990-ot1wi3xi 709 6 l l NNP cord-016990-ot1wi3xi 709 7 , , , cord-016990-ot1wi3xi 709 8 and and CC cord-016990-ot1wi3xi 709 9 HPIV-3 HPIV-3 NNP cord-016990-ot1wi3xi 709 10 have have VBP cord-016990-ot1wi3xi 709 11 been be VBN cord-016990-ot1wi3xi 709 12 definitively definitively RB cord-016990-ot1wi3xi 709 13 linked link VBN cord-016990-ot1wi3xi 709 14 to to IN cord-016990-ot1wi3xi 709 15 cases case NNS cord-016990-ot1wi3xi 709 16 of of IN cord-016990-ot1wi3xi 709 17 lower low JJR cord-016990-ot1wi3xi 709 18 respiratory respiratory JJ cord-016990-ot1wi3xi 709 19 tract tract NN cord-016990-ot1wi3xi 709 20 disease disease NN cord-016990-ot1wi3xi 709 21 in in IN cord-016990-ot1wi3xi 709 22 infants infant NNS cord-016990-ot1wi3xi 709 23 and and CC cord-016990-ot1wi3xi 709 24 young young JJ cord-016990-ot1wi3xi 709 25 children child NNS cord-016990-ot1wi3xi 709 26 , , , cord-016990-ot1wi3xi 709 27 the the DT cord-016990-ot1wi3xi 709 28 relative relative JJ cord-016990-ot1wi3xi 709 29 contribution contribution NN cord-016990-ot1wi3xi 709 30 of of IN cord-016990-ot1wi3xi 709 31 HMPV HMPV NNP cord-016990-ot1wi3xi 709 32 remains remain VBZ cord-016990-ot1wi3xi 709 33 undetermined undetermined JJ cord-016990-ot1wi3xi 709 34 . . . cord-016990-ot1wi3xi 710 1 Like like IN cord-016990-ot1wi3xi 710 2 RSV RSV NNP cord-016990-ot1wi3xi 710 3 and and CC cord-016990-ot1wi3xi 710 4 the the DT cord-016990-ot1wi3xi 710 5 HPIVs hpiv NNS cord-016990-ot1wi3xi 710 6 , , , cord-016990-ot1wi3xi 710 7 studies study NNS cord-016990-ot1wi3xi 710 8 suggest suggest VBP cord-016990-ot1wi3xi 710 9 that that IN cord-016990-ot1wi3xi 710 10 HMPV HMPV NNP cord-016990-ot1wi3xi 710 11 may may MD cord-016990-ot1wi3xi 710 12 also also RB cord-016990-ot1wi3xi 710 13 contribute contribute VB cord-016990-ot1wi3xi 710 14 to to IN cord-016990-ot1wi3xi 710 15 respiratory respiratory JJ cord-016990-ot1wi3xi 710 16 disease disease NN cord-016990-ot1wi3xi 710 17 in in IN cord-016990-ot1wi3xi 710 18 elderly elderly JJ cord-016990-ot1wi3xi 710 19 adults adult NNS cord-016990-ot1wi3xi 710 20 and and CC cord-016990-ot1wi3xi 710 21 the the DT cord-016990-ot1wi3xi 710 22 immunocompromised immunocompromised JJ cord-016990-ot1wi3xi 710 23 . . . cord-016990-ot1wi3xi 711 1 288 288 CD cord-016990-ot1wi3xi 711 2 - - HYPH cord-016990-ot1wi3xi 711 3 29o 29o CD cord-016990-ot1wi3xi 711 4 Histopathologic Histopathologic NNP cord-016990-ot1wi3xi 711 5 descriptions description NNS cord-016990-ot1wi3xi 711 6 of of IN cord-016990-ot1wi3xi 711 7 features feature NNS cord-016990-ot1wi3xi 711 8 of of IN cord-016990-ot1wi3xi 711 9 HMPV hmpv NN cord-016990-ot1wi3xi 711 10 infections infection NNS cord-016990-ot1wi3xi 711 11 are be VBP cord-016990-ot1wi3xi 711 12 few few JJ cord-016990-ot1wi3xi 711 13 and and CC cord-016990-ot1wi3xi 711 14 have have VBP cord-016990-ot1wi3xi 711 15 not not RB cord-016990-ot1wi3xi 711 16 been be VBN cord-016990-ot1wi3xi 711 17 well well RB cord-016990-ot1wi3xi 711 18 described describe VBN cord-016990-ot1wi3xi 711 19 . . . cord-016990-ot1wi3xi 712 1 [ [ -LRB- cord-016990-ot1wi3xi 712 2 291 291 CD cord-016990-ot1wi3xi 712 3 ] ] -RRB- cord-016990-ot1wi3xi 712 4 [ [ -LRB- cord-016990-ot1wi3xi 712 5 292 292 CD cord-016990-ot1wi3xi 712 6 ] ] -RRB- cord-016990-ot1wi3xi 712 7 [ [ -LRB- cord-016990-ot1wi3xi 712 8 293 293 CD cord-016990-ot1wi3xi 712 9 ] ] -RRB- cord-016990-ot1wi3xi 712 10 [ [ -LRB- cord-016990-ot1wi3xi 712 11 294 294 CD cord-016990-ot1wi3xi 712 12 ] ] -RRB- cord-016990-ot1wi3xi 713 1 This this DT cord-016990-ot1wi3xi 713 2 is be VBZ cord-016990-ot1wi3xi 713 3 partly partly RB cord-016990-ot1wi3xi 713 4 related relate VBN cord-016990-ot1wi3xi 713 5 to to IN cord-016990-ot1wi3xi 713 6 interpreting interpret VBG cord-016990-ot1wi3xi 713 7 the the DT cord-016990-ot1wi3xi 713 8 clinical clinical JJ cord-016990-ot1wi3xi 713 9 significance significance NN cord-016990-ot1wi3xi 713 10 of of IN cord-016990-ot1wi3xi 713 11 virus virus NN cord-016990-ot1wi3xi 713 12 detection detection NN cord-016990-ot1wi3xi 713 13 in in IN cord-016990-ot1wi3xi 713 14 context context NN cord-016990-ot1wi3xi 713 15 with with IN cord-016990-ot1wi3xi 713 16 the the DT cord-016990-ot1wi3xi 713 17 ubiquitous ubiquitous JJ cord-016990-ot1wi3xi 713 18 nature nature NN cord-016990-ot1wi3xi 713 19 of of IN cord-016990-ot1wi3xi 713 20 the the DT cord-016990-ot1wi3xi 713 21 virus virus NN cord-016990-ot1wi3xi 713 22 . . . cord-016990-ot1wi3xi 714 1 Virus virus NN cord-016990-ot1wi3xi 714 2 detection detection NN cord-016990-ot1wi3xi 714 3 in in IN cord-016990-ot1wi3xi 714 4 such such JJ cord-016990-ot1wi3xi 714 5 cases case NNS cord-016990-ot1wi3xi 714 6 is be VBZ cord-016990-ot1wi3xi 714 7 usually usually RB cord-016990-ot1wi3xi 714 8 made make VBN cord-016990-ot1wi3xi 714 9 by by IN cord-016990-ot1wi3xi 714 10 culture culture NN cord-016990-ot1wi3xi 714 11 isolation isolation NN cord-016990-ot1wi3xi 714 12 of of IN cord-016990-ot1wi3xi 714 13 the the DT cord-016990-ot1wi3xi 714 14 virus virus NN cord-016990-ot1wi3xi 714 15 from from IN cord-016990-ot1wi3xi 714 16 upper upper JJ cord-016990-ot1wi3xi 714 17 airways airway NNS cord-016990-ot1wi3xi 714 18 or or CC cord-016990-ot1wi3xi 714 19 by by IN cord-016990-ot1wi3xi 714 20 PCR PCR NNP cord-016990-ot1wi3xi 714 21 assays assay NNS cord-016990-ot1wi3xi 714 22 performed perform VBN cord-016990-ot1wi3xi 714 23 on on IN cord-016990-ot1wi3xi 714 24 nasopharyngeal nasopharyngeal JJ cord-016990-ot1wi3xi 714 25 aspirates aspirate NNS cord-016990-ot1wi3xi 714 26 or or CC cord-016990-ot1wi3xi 714 27 BAL bal NN cord-016990-ot1wi3xi 714 28 washings washing NNS cord-016990-ot1wi3xi 714 29 . . . cord-016990-ot1wi3xi 715 1 In in IN cord-016990-ot1wi3xi 715 2 nonhuman nonhuman NN cord-016990-ot1wi3xi 715 3 primates primate NNS cord-016990-ot1wi3xi 715 4 viral viral JJ cord-016990-ot1wi3xi 715 5 antigens antigen NNS cord-016990-ot1wi3xi 715 6 are be VBP cord-016990-ot1wi3xi 715 7 observed observe VBN cord-016990-ot1wi3xi 715 8 in in IN cord-016990-ot1wi3xi 715 9 ciliated ciliated JJ cord-016990-ot1wi3xi 715 10 epithelial epithelial JJ cord-016990-ot1wi3xi 715 11 cells cell NNS cord-016990-ot1wi3xi 715 12 , , , cord-016990-ot1wi3xi 715 13 type type NN cord-016990-ot1wi3xi 715 14 1 1 CD cord-016990-ot1wi3xi 715 15 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 715 16 , , , cord-016990-ot1wi3xi 715 17 and and CC cord-016990-ot1wi3xi 715 18 alveolar alveolar JJ cord-016990-ot1wi3xi 715 19 macrophages macrophage NNS cord-016990-ot1wi3xi 715 20 . . . cord-016990-ot1wi3xi 716 1 This this DT cord-016990-ot1wi3xi 716 2 distribution distribution NN cord-016990-ot1wi3xi 716 3 is be VBZ cord-016990-ot1wi3xi 716 4 associated associate VBN cord-016990-ot1wi3xi 716 5 with with IN cord-016990-ot1wi3xi 716 6 mild mild JJ cord-016990-ot1wi3xi 716 7 , , , cord-016990-ot1wi3xi 716 8 multifocal multifocal JJ cord-016990-ot1wi3xi 716 9 , , , cord-016990-ot1wi3xi 716 10 erosive erosive JJ cord-016990-ot1wi3xi 716 11 , , , cord-016990-ot1wi3xi 716 12 and and CC cord-016990-ot1wi3xi 716 13 inflammatory inflammatory JJ cord-016990-ot1wi3xi 716 14 changes change NNS cord-016990-ot1wi3xi 716 15 in in IN cord-016990-ot1wi3xi 716 16 airways airways NNP cord-016990-ot1wi3xi 716 17 , , , cord-016990-ot1wi3xi 716 18 and and CC cord-016990-ot1wi3xi 716 19 an an DT cord-016990-ot1wi3xi 716 20 increased increase VBN cord-016990-ot1wi3xi 716 21 number number NN cord-016990-ot1wi3xi 716 22 of of IN cord-016990-ot1wi3xi 716 23 foamy foamy JJ cord-016990-ot1wi3xi 716 24 macrophages macrophage NNS cord-016990-ot1wi3xi 716 25 in in IN cord-016990-ot1wi3xi 716 26 alveoli alveolus NNS cord-016990-ot1wi3xi 716 27 . . . cord-016990-ot1wi3xi 717 1 291 291 CD cord-016990-ot1wi3xi 718 1 The the DT cord-016990-ot1wi3xi 718 2 BAL bal NN cord-016990-ot1wi3xi 718 3 specimens specimen NNS cord-016990-ot1wi3xi 718 4 collected collect VBN cord-016990-ot1wi3xi 718 5 from from IN cord-016990-ot1wi3xi 718 6 patients patient NNS cord-016990-ot1wi3xi 718 7 within within IN cord-016990-ot1wi3xi 718 8 a a DT cord-016990-ot1wi3xi 718 9 few few JJ cord-016990-ot1wi3xi 718 10 days day NNS cord-016990-ot1wi3xi 718 11 of of IN cord-016990-ot1wi3xi 718 12 a a DT cord-016990-ot1wi3xi 718 13 positive positive JJ cord-016990-ot1wi3xi 718 14 HMPV hmpv NN cord-016990-ot1wi3xi 718 15 assay assay NN cord-016990-ot1wi3xi 718 16 show show VBP cord-016990-ot1wi3xi 718 17 degenerative degenerative JJ cord-016990-ot1wi3xi 718 18 changes change NNS cord-016990-ot1wi3xi 718 19 and and CC cord-016990-ot1wi3xi 718 20 cytoplasmic cytoplasmic JJ cord-016990-ot1wi3xi 718 21 inclusions inclusion NNS cord-016990-ot1wi3xi 718 22 within within IN cord-016990-ot1wi3xi 718 23 epithelial epithelial JJ cord-016990-ot1wi3xi 718 24 cells cell NNS cord-016990-ot1wi3xi 718 25 , , , cord-016990-ot1wi3xi 718 26 multinucleated multinucleate VBN cord-016990-ot1wi3xi 718 27 giant giant JJ cord-016990-ot1wi3xi 718 28 cells cell NNS cord-016990-ot1wi3xi 718 29 , , , cord-016990-ot1wi3xi 718 30 and and CC cord-016990-ot1wi3xi 718 31 histiocytes histiocyte NNS cord-016990-ot1wi3xi 718 32 . . . cord-016990-ot1wi3xi 719 1 The the DT cord-016990-ot1wi3xi 719 2 intracytoplasmic intracytoplasmic JJ cord-016990-ot1wi3xi 719 3 inclusions inclusion NNS cord-016990-ot1wi3xi 719 4 are be VBP cord-016990-ot1wi3xi 719 5 ill ill RB cord-016990-ot1wi3xi 719 6 - - HYPH cord-016990-ot1wi3xi 719 7 defined define VBN cord-016990-ot1wi3xi 719 8 , , , cord-016990-ot1wi3xi 719 9 eosinophilic eosinophilic JJ cord-016990-ot1wi3xi 719 10 structures structure NNS cord-016990-ot1wi3xi 719 11 that that WDT cord-016990-ot1wi3xi 719 12 measure measure VBP cord-016990-ot1wi3xi 719 13 3 3 CD cord-016990-ot1wi3xi 719 14 to to IN cord-016990-ot1wi3xi 719 15 4 4 CD cord-016990-ot1wi3xi 720 1 ~m ~m JJ cord-016990-ot1wi3xi 720 2 . . . cord-016990-ot1wi3xi 721 1 293 293 CD cord-016990-ot1wi3xi 721 2 Lung Lung NNP cord-016990-ot1wi3xi 721 3 biopsy biopsy NN cord-016990-ot1wi3xi 721 4 or or CC cord-016990-ot1wi3xi 721 5 autopsy autopsy JJ cord-016990-ot1wi3xi 721 6 tissue tissue NN cord-016990-ot1wi3xi 721 7 obtained obtain VBD cord-016990-ot1wi3xi 721 8 and and CC cord-016990-ot1wi3xi 721 9 examined examine VBN cord-016990-ot1wi3xi 721 10 later later RB cord-016990-ot1wi3xi 721 11 in in IN cord-016990-ot1wi3xi 721 12 the the DT cord-016990-ot1wi3xi 721 13 disease disease NN cord-016990-ot1wi3xi 721 14 show show VBP cord-016990-ot1wi3xi 721 15 chronic chronic JJ cord-016990-ot1wi3xi 721 16 airway airway NN cord-016990-ot1wi3xi 721 17 inflammation inflammation NN cord-016990-ot1wi3xi 721 18 , , , cord-016990-ot1wi3xi 721 19 intraalveolar intraalveolar NN cord-016990-ot1wi3xi 721 20 foamy foamy NN cord-016990-ot1wi3xi 721 21 and and CC cord-016990-ot1wi3xi 721 22 hemosiderin hemosiderin NNP cord-016990-ot1wi3xi 721 23 - - HYPH cord-016990-ot1wi3xi 721 24 laden laden JJ cord-016990-ot1wi3xi 721 25 macrophages macrophage NNS cord-016990-ot1wi3xi 721 26 , , , cord-016990-ot1wi3xi 721 27 and and CC cord-016990-ot1wi3xi 721 28 acute acute JJ cord-016990-ot1wi3xi 721 29 and and CC cord-016990-ot1wi3xi 721 30 organizing organize VBG cord-016990-ot1wi3xi 721 31 lung lung NN cord-016990-ot1wi3xi 721 32 injury injury NN cord-016990-ot1wi3xi 721 33 including include VBG cord-016990-ot1wi3xi 721 34 areas area NNS cord-016990-ot1wi3xi 721 35 of of IN cord-016990-ot1wi3xi 721 36 diffuse diffuse JJ cord-016990-ot1wi3xi 721 37 alveolar alveolar NN cord-016990-ot1wi3xi 721 38 damage damage NN cord-016990-ot1wi3xi 721 39 with with IN cord-016990-ot1wi3xi 721 40 hyaline hyaline JJ cord-016990-ot1wi3xi 721 41 membrane membrane NN cord-016990-ot1wi3xi 721 42 formation formation NN cord-016990-ot1wi3xi 721 43 and and CC cord-016990-ot1wi3xi 721 44 foci foci NN cord-016990-ot1wi3xi 721 45 of of IN cord-016990-ot1wi3xi 721 46 a a DT cord-016990-ot1wi3xi 721 47 bronchiolitis bronchiolitis NN cord-016990-ot1wi3xi 721 48 obliterans obliterans NNP cord-016990-ot1wi3xi 721 49 / / SYM cord-016990-ot1wi3xi 721 50 organizing organize VBG cord-016990-ot1wi3xi 721 51 pneumonia pneumonia NN cord-016990-ot1wi3xi 721 52 like like IN cord-016990-ot1wi3xi 721 53 reaction reaction NN cord-016990-ot1wi3xi 721 54 ( ( -LRB- cord-016990-ot1wi3xi 721 55 Fig fig NN cord-016990-ot1wi3xi 721 56 . . . cord-016990-ot1wi3xi 721 57 _SP cord-016990-ot1wi3xi 721 58 11 11 CD cord-016990-ot1wi3xi 721 59 .14 .14 NFP cord-016990-ot1wi3xi 721 60 ) ) -RRB- cord-016990-ot1wi3xi 721 61 . . . cord-016990-ot1wi3xi 722 1 In in IN cord-016990-ot1wi3xi 722 2 such such JJ cord-016990-ot1wi3xi 722 3 cases case NNS cord-016990-ot1wi3xi 722 4 , , , cord-016990-ot1wi3xi 722 5 typical typical JJ cord-016990-ot1wi3xi 722 6 multinucleated multinucleated JJ cord-016990-ot1wi3xi 722 7 giant giant JJ cord-016990-ot1wi3xi 722 8 cells cell NNS cord-016990-ot1wi3xi 722 9 or or CC cord-016990-ot1wi3xi 722 10 viral viral JJ cord-016990-ot1wi3xi 722 11 inclusion inclusion NN cord-016990-ot1wi3xi 722 12 can can MD cord-016990-ot1wi3xi 722 13 not not RB cord-016990-ot1wi3xi 722 14 be be VB cord-016990-ot1wi3xi 722 15 identified identify VBN cord-016990-ot1wi3xi 722 16 . . . cord-016990-ot1wi3xi 723 1 292 292 CD cord-016990-ot1wi3xi 723 2 -294 -294 NN cord-016990-ot1wi3xi 724 1 In in IN cord-016990-ot1wi3xi 724 2 - - HYPH cord-016990-ot1wi3xi 724 3 situ situ NN cord-016990-ot1wi3xi 724 4 hybridization hybridization NN cord-016990-ot1wi3xi 724 5 studies study NNS cord-016990-ot1wi3xi 724 6 on on IN cord-016990-ot1wi3xi 724 7 limited limited JJ cord-016990-ot1wi3xi 724 8 number number NN cord-016990-ot1wi3xi 724 9 of of IN cord-016990-ot1wi3xi 724 10 human human JJ cord-016990-ot1wi3xi 724 11 cases case NNS cord-016990-ot1wi3xi 724 12 Human Human NNP cord-016990-ot1wi3xi 724 13 metapneumovirus metapneumovirus NNP cord-016990-ot1wi3xi 724 14 is be VBZ cord-016990-ot1wi3xi 724 15 difficult difficult JJ cord-016990-ot1wi3xi 724 16 to to TO cord-016990-ot1wi3xi 724 17 identify identify VB cord-016990-ot1wi3xi 724 18 with with IN cord-016990-ot1wi3xi 724 19 commonly commonly RB cord-016990-ot1wi3xi 724 20 used use VBN cord-016990-ot1wi3xi 724 21 viral viral JJ cord-016990-ot1wi3xi 724 22 diagnostic diagnostic JJ cord-016990-ot1wi3xi 724 23 procedures procedure NNS cord-016990-ot1wi3xi 724 24 . . . cord-016990-ot1wi3xi 725 1 The the DT cord-016990-ot1wi3xi 725 2 virus virus NN cord-016990-ot1wi3xi 725 3 replicates replicate VBZ cord-016990-ot1wi3xi 725 4 slowly slowly RB cord-016990-ot1wi3xi 725 5 in in IN cord-016990-ot1wi3xi 725 6 primary primary JJ cord-016990-ot1wi3xi 725 7 and and CC cord-016990-ot1wi3xi 725 8 tertiary tertiary JJ cord-016990-ot1wi3xi 725 9 monkey monkey NN cord-016990-ot1wi3xi 725 10 kidney kidney NN cord-016990-ot1wi3xi 725 11 cell cell NN cord-016990-ot1wi3xi 725 12 lines line NNS cord-016990-ot1wi3xi 725 13 , , , cord-016990-ot1wi3xi 725 14 and and CC cord-016990-ot1wi3xi 725 15 the the DT cord-016990-ot1wi3xi 725 16 cytopathic cytopathic JJ cord-016990-ot1wi3xi 725 17 effect effect NN cord-016990-ot1wi3xi 725 18 can can MD cord-016990-ot1wi3xi 725 19 be be VB cord-016990-ot1wi3xi 725 20 difficult difficult JJ cord-016990-ot1wi3xi 725 21 to to TO cord-016990-ot1wi3xi 725 22 discern discern VB cord-016990-ot1wi3xi 725 23 . . . cord-016990-ot1wi3xi 726 1 Commercial commercial JJ cord-016990-ot1wi3xi 726 2 monoclonal monoclonal JJ cord-016990-ot1wi3xi 726 3 antibody antibody NN cord-016990-ot1wi3xi 726 4 reagents reagent NNS cord-016990-ot1wi3xi 726 5 to to IN cord-016990-ot1wi3xi 726 6 HMPV HMPV NNP cord-016990-ot1wi3xi 726 7 are be VBP cord-016990-ot1wi3xi 726 8 not not RB cord-016990-ot1wi3xi 726 9 widely widely RB cord-016990-ot1wi3xi 726 10 available available JJ cord-016990-ot1wi3xi 726 11 . . . cord-016990-ot1wi3xi 727 1 Most Most JJS cord-016990-ot1wi3xi 727 2 HMPV hmpv NN cord-016990-ot1wi3xi 727 3 studies study NNS cord-016990-ot1wi3xi 727 4 have have VBP cord-016990-ot1wi3xi 727 5 been be VBN cord-016990-ot1wi3xi 727 6 conducted conduct VBN cord-016990-ot1wi3xi 727 7 using use VBG cord-016990-ot1wi3xi 727 8 RT RT NNP cord-016990-ot1wi3xi 727 9 - - HYPH cord-016990-ot1wi3xi 727 10 PCR PCR NNP cord-016990-ot1wi3xi 727 11 assays assay NNS cord-016990-ot1wi3xi 727 12 or or CC cord-016990-ot1wi3xi 727 13 by by IN cord-016990-ot1wi3xi 727 14 demonstration demonstration NN cord-016990-ot1wi3xi 727 15 of of IN cord-016990-ot1wi3xi 727 16 a a DT cord-016990-ot1wi3xi 727 17 rise rise NN cord-016990-ot1wi3xi 727 18 in in IN cord-016990-ot1wi3xi 727 19 HMPV hmpv NN cord-016990-ot1wi3xi 727 20 - - HYPH cord-016990-ot1wi3xi 727 21 specific specific JJ cord-016990-ot1wi3xi 727 22 serum serum NN cord-016990-ot1wi3xi 727 23 antibodies antibody NNS cord-016990-ot1wi3xi 727 24 . . . cord-016990-ot1wi3xi 727 25 _SP cord-016990-ot1wi3xi 728 1 Two two CD cord-016990-ot1wi3xi 728 2 novel novel NN cord-016990-ot1wi3xi 728 3 paramyxoviruses paramyxovirus NNS cord-016990-ot1wi3xi 728 4 , , , cord-016990-ot1wi3xi 728 5 Hendra Hendra NNP cord-016990-ot1wi3xi 728 6 and and CC cord-016990-ot1wi3xi 728 7 Nipah Nipah NNP cord-016990-ot1wi3xi 728 8 , , , cord-016990-ot1wi3xi 728 9 have have VBP cord-016990-ot1wi3xi 728 10 been be VBN cord-016990-ot1wi3xi 728 11 recently recently RB cord-016990-ot1wi3xi 728 12 identified identify VBN cord-016990-ot1wi3xi 728 13 in in IN cord-016990-ot1wi3xi 728 14 Australia Australia NNP cord-016990-ot1wi3xi 728 15 and and CC cord-016990-ot1wi3xi 728 16 Malaysia Malaysia NNP cord-016990-ot1wi3xi 728 17 ; ; : cord-016990-ot1wi3xi 728 18 these these DT cord-016990-ot1wi3xi 728 19 viruses virus NNS cord-016990-ot1wi3xi 728 20 have have VBP cord-016990-ot1wi3xi 728 21 been be VBN cord-016990-ot1wi3xi 728 22 associated associate VBN cord-016990-ot1wi3xi 728 23 with with IN cord-016990-ot1wi3xi 728 24 acute acute JJ cord-016990-ot1wi3xi 728 25 febrile febrile JJ cord-016990-ot1wi3xi 728 26 encephalitis encephalitis NN cord-016990-ot1wi3xi 728 27 and and CC cord-016990-ot1wi3xi 728 28 respiratory respiratory JJ cord-016990-ot1wi3xi 728 29 tract tract NN cord-016990-ot1wi3xi 728 30 disease disease NN cord-016990-ot1wi3xi 728 31 . . . cord-016990-ot1wi3xi 729 1 Both both DT cord-016990-ot1wi3xi 729 2 infections infection NNS cord-016990-ot1wi3xi 729 3 are be VBP cord-016990-ot1wi3xi 729 4 zoonotic zoonotic JJ cord-016990-ot1wi3xi 729 5 . . . cord-016990-ot1wi3xi 730 1 Hendra Hendra NNP cord-016990-ot1wi3xi 730 2 was be VBD cord-016990-ot1wi3xi 730 3 first first RB cord-016990-ot1wi3xi 730 4 identified identify VBN cord-016990-ot1wi3xi 730 5 in in IN cord-016990-ot1wi3xi 730 6 1994 1994 CD cord-016990-ot1wi3xi 730 7 when when WRB cord-016990-ot1wi3xi 730 8 patients patient NNS cord-016990-ot1wi3xi 730 9 who who WP cord-016990-ot1wi3xi 730 10 came come VBD cord-016990-ot1wi3xi 730 11 in in IN cord-016990-ot1wi3xi 730 12 close close JJ cord-016990-ot1wi3xi 730 13 contact contact NN cord-016990-ot1wi3xi 730 14 with with IN cord-016990-ot1wi3xi 730 15 sick sick JJ cord-016990-ot1wi3xi 730 16 horses horse NNS cord-016990-ot1wi3xi 730 17 developed develop VBD cord-016990-ot1wi3xi 730 18 an an DT cord-016990-ot1wi3xi 730 19 influenza influenza NN cord-016990-ot1wi3xi 730 20 - - HYPH cord-016990-ot1wi3xi 730 21 like like JJ cord-016990-ot1wi3xi 730 22 illness illness NN cord-016990-ot1wi3xi 730 23 . . . cord-016990-ot1wi3xi 731 1 Two two CD cord-016990-ot1wi3xi 731 2 patients patient NNS cord-016990-ot1wi3xi 731 3 died die VBD cord-016990-ot1wi3xi 731 4 with with IN cord-016990-ot1wi3xi 731 5 pneumonitis pneumonitis NN cord-016990-ot1wi3xi 731 6 and and CC cord-016990-ot1wi3xi 731 7 multiorgan multiorgan NNP cord-016990-ot1wi3xi 731 8 failure failure NN cord-016990-ot1wi3xi 731 9 . . . cord-016990-ot1wi3xi 732 1 30 30 CD cord-016990-ot1wi3xi 733 1 The the DT cord-016990-ot1wi3xi 733 2 closely closely RB cord-016990-ot1wi3xi 733 3 related relate VBN cord-016990-ot1wi3xi 733 4 Nipah Nipah NNP cord-016990-ot1wi3xi 733 5 virus virus NN cord-016990-ot1wi3xi 733 6 was be VBD cord-016990-ot1wi3xi 733 7 identified identify VBN cord-016990-ot1wi3xi 733 8 during during IN cord-016990-ot1wi3xi 733 9 an an DT cord-016990-ot1wi3xi 733 10 outbreak outbreak NN cord-016990-ot1wi3xi 733 11 in in IN cord-016990-ot1wi3xi 733 12 Malaysia Malaysia NNP cord-016990-ot1wi3xi 733 13 and and CC cord-016990-ot1wi3xi 733 14 Singapore Singapore NNP cord-016990-ot1wi3xi 733 15 during during IN cord-016990-ot1wi3xi 733 16 1998 1998 CD cord-016990-ot1wi3xi 733 17 - - SYM cord-016990-ot1wi3xi 733 18 1999 1999 CD cord-016990-ot1wi3xi 733 19 that that WDT cord-016990-ot1wi3xi 733 20 included include VBD cord-016990-ot1wi3xi 733 21 more more JJR cord-016990-ot1wi3xi 733 22 than than IN cord-016990-ot1wi3xi 733 23 250 250 CD cord-016990-ot1wi3xi 733 24 patients patient NNS cord-016990-ot1wi3xi 733 25 . . . cord-016990-ot1wi3xi 734 1 Patients patient NNS cord-016990-ot1wi3xi 734 2 presented present VBN cord-016990-ot1wi3xi 734 3 with with IN cord-016990-ot1wi3xi 734 4 a a DT cord-016990-ot1wi3xi 734 5 severe severe JJ cord-016990-ot1wi3xi 734 6 acute acute JJ cord-016990-ot1wi3xi 734 7 encephalitic encephalitic JJ cord-016990-ot1wi3xi 734 8 syndrome syndrome NN cord-016990-ot1wi3xi 734 9 , , , cord-016990-ot1wi3xi 734 10 but but CC cord-016990-ot1wi3xi 734 11 some some DT cord-016990-ot1wi3xi 734 12 also also RB cord-016990-ot1wi3xi 734 13 had have VBD cord-016990-ot1wi3xi 734 14 significant significant JJ cord-016990-ot1wi3xi 734 15 pulmonary pulmonary JJ cord-016990-ot1wi3xi 734 16 manifestations manifestation NNS cord-016990-ot1wi3xi 734 17 . . . cord-016990-ot1wi3xi 735 1 22 22 CD cord-016990-ot1wi3xi 735 2 , , , cord-016990-ot1wi3xi 735 3 295 295 CD cord-016990-ot1wi3xi 735 4 - - SYM cord-016990-ot1wi3xi 735 5 302 302 CD cord-016990-ot1wi3xi 735 6 Most Most JJS cord-016990-ot1wi3xi 735 7 of of IN cord-016990-ot1wi3xi 735 8 the the DT cord-016990-ot1wi3xi 735 9 patients patient NNS cord-016990-ot1wi3xi 735 10 had have VBD cord-016990-ot1wi3xi 735 11 a a DT cord-016990-ot1wi3xi 735 12 history history NN cord-016990-ot1wi3xi 735 13 of of IN cord-016990-ot1wi3xi 735 14 contact contact NN cord-016990-ot1wi3xi 735 15 with with IN cord-016990-ot1wi3xi 735 16 pigs pig NNS cord-016990-ot1wi3xi 735 17 , , , cord-016990-ot1wi3xi 735 18 most most JJS cord-016990-ot1wi3xi 735 19 of of IN cord-016990-ot1wi3xi 735 20 them -PRON- PRP cord-016990-ot1wi3xi 735 21 being be VBG cord-016990-ot1wi3xi 735 22 pig pig NN cord-016990-ot1wi3xi 735 23 farmers farmer NNS cord-016990-ot1wi3xi 735 24 . . . cord-016990-ot1wi3xi 736 1 In in IN cord-016990-ot1wi3xi 736 2 Bangladesh Bangladesh NNP cord-016990-ot1wi3xi 736 3 in in IN cord-016990-ot1wi3xi 736 4 2001 2001 CD cord-016990-ot1wi3xi 736 5 and and CC cord-016990-ot1wi3xi 736 6 2003 2003 CD cord-016990-ot1wi3xi 736 7 , , , cord-016990-ot1wi3xi 736 8 outbreaks outbreak NNS cord-016990-ot1wi3xi 736 9 of of IN cord-016990-ot1wi3xi 736 10 Nipah Nipah NNP cord-016990-ot1wi3xi 736 11 encephalitis encephalitis RB cord-016990-ot1wi3xi 736 12 occurred occur VBD cord-016990-ot1wi3xi 736 13 . . . cord-016990-ot1wi3xi 737 1 303 303 CD cord-016990-ot1wi3xi 737 2 , , , cord-016990-ot1wi3xi 737 3 304 304 CD cord-016990-ot1wi3xi 737 4 Similar similar JJ cord-016990-ot1wi3xi 737 5 to to IN cord-016990-ot1wi3xi 737 6 the the DT cord-016990-ot1wi3xi 737 7 Malaysian malaysian JJ cord-016990-ot1wi3xi 737 8 outbreak outbreak NN cord-016990-ot1wi3xi 737 9 , , , cord-016990-ot1wi3xi 737 10 the the DT cord-016990-ot1wi3xi 737 11 most most RBS cord-016990-ot1wi3xi 737 12 prominent prominent JJ cord-016990-ot1wi3xi 737 13 symptoms symptom NNS cord-016990-ot1wi3xi 737 14 were be VBD cord-016990-ot1wi3xi 737 15 fever fever NN cord-016990-ot1wi3xi 737 16 , , , cord-016990-ot1wi3xi 737 17 headache headache NN cord-016990-ot1wi3xi 737 18 , , , cord-016990-ot1wi3xi 737 19 vomiting vomit VBG cord-016990-ot1wi3xi 737 20 , , , cord-016990-ot1wi3xi 737 21 and and CC cord-016990-ot1wi3xi 737 22 an an DT cord-016990-ot1wi3xi 737 23 altered altered JJ cord-016990-ot1wi3xi 737 24 level level NN cord-016990-ot1wi3xi 737 25 of of IN cord-016990-ot1wi3xi 737 26 consciousness consciousness NN cord-016990-ot1wi3xi 737 27 . . . cord-016990-ot1wi3xi 738 1 Respiratory respiratory JJ cord-016990-ot1wi3xi 738 2 illness illness NN cord-016990-ot1wi3xi 738 3 was be VBD cord-016990-ot1wi3xi 738 4 much much RB cord-016990-ot1wi3xi 738 5 more more RBR cord-016990-ot1wi3xi 738 6 common common JJ cord-016990-ot1wi3xi 738 7 in in IN cord-016990-ot1wi3xi 738 8 the the DT cord-016990-ot1wi3xi 738 9 Bangladesh Bangladesh NNP cord-016990-ot1wi3xi 738 10 cases case NNS cord-016990-ot1wi3xi 738 11 , , , cord-016990-ot1wi3xi 738 12 however however RB cord-016990-ot1wi3xi 738 13 , , , cord-016990-ot1wi3xi 738 14 with with IN cord-016990-ot1wi3xi 738 15 64 64 CD cord-016990-ot1wi3xi 738 16 % % NN cord-016990-ot1wi3xi 738 17 having have VBG cord-016990-ot1wi3xi 738 18 cough cough NN cord-016990-ot1wi3xi 738 19 and and CC cord-016990-ot1wi3xi 738 20 dyspnea dyspnea NN cord-016990-ot1wi3xi 738 21 . . . cord-016990-ot1wi3xi 739 1 The the DT cord-016990-ot1wi3xi 739 2 reason reason NN cord-016990-ot1wi3xi 739 3 for for IN cord-016990-ot1wi3xi 739 4 increased increase VBN cord-016990-ot1wi3xi 739 5 involvement involvement NN cord-016990-ot1wi3xi 739 6 of of IN cord-016990-ot1wi3xi 739 7 the the DT cord-016990-ot1wi3xi 739 8 respiratory respiratory JJ cord-016990-ot1wi3xi 739 9 tract tract NN cord-016990-ot1wi3xi 739 10 in in IN cord-016990-ot1wi3xi 739 11 this this DT cord-016990-ot1wi3xi 739 12 outbreak outbreak NN cord-016990-ot1wi3xi 739 13 is be VBZ cord-016990-ot1wi3xi 739 14 not not RB cord-016990-ot1wi3xi 739 15 known know VBN cord-016990-ot1wi3xi 739 16 . . . cord-016990-ot1wi3xi 740 1 Epidemiologic epidemiologic JJ cord-016990-ot1wi3xi 740 2 and and CC cord-016990-ot1wi3xi 740 3 laboratory laboratory NN cord-016990-ot1wi3xi 740 4 investigations investigation NNS cord-016990-ot1wi3xi 740 5 identified identify VBD cord-016990-ot1wi3xi 740 6 fruit fruit NN cord-016990-ot1wi3xi 740 7 bats bat NNS cord-016990-ot1wi3xi 740 8 of of IN cord-016990-ot1wi3xi 740 9 the the DT cord-016990-ot1wi3xi 740 10 Pteropus Pteropus NNP cord-016990-ot1wi3xi 740 11 genus genus NN cord-016990-ot1wi3xi 740 12 as as IN cord-016990-ot1wi3xi 740 13 asymptomatic asymptomatic JJ cord-016990-ot1wi3xi 740 14 carriers carrier NNS cord-016990-ot1wi3xi 740 15 of of IN cord-016990-ot1wi3xi 740 16 Hendra Hendra NNP cord-016990-ot1wi3xi 740 17 and and CC cord-016990-ot1wi3xi 740 18 Nipah Nipah NNP cord-016990-ot1wi3xi 740 19 viruses virus NNS cord-016990-ot1wi3xi 740 20 and and CC cord-016990-ot1wi3xi 740 21 possible possible JJ cord-016990-ot1wi3xi 740 22 animal animal NN cord-016990-ot1wi3xi 740 23 reservoirs reservoir NNS cord-016990-ot1wi3xi 740 24 . . . cord-016990-ot1wi3xi 741 1 [ [ -LRB- cord-016990-ot1wi3xi 741 2 305 305 CD cord-016990-ot1wi3xi 741 3 ] ] -RRB- cord-016990-ot1wi3xi 741 4 [ [ -LRB- cord-016990-ot1wi3xi 741 5 306 306 CD cord-016990-ot1wi3xi 741 6 ] ] -RRB- cord-016990-ot1wi3xi 741 7 [ [ -LRB- cord-016990-ot1wi3xi 741 8 307 307 CD cord-016990-ot1wi3xi 741 9 ] ] -RRB- cord-016990-ot1wi3xi 741 10 [ [ -LRB- cord-016990-ot1wi3xi 741 11 308 308 CD cord-016990-ot1wi3xi 741 12 ] ] -RRB- cord-016990-ot1wi3xi 741 13 [ [ -LRB- cord-016990-ot1wi3xi 741 14 309 309 CD cord-016990-ot1wi3xi 741 15 ] ] -RRB- cord-016990-ot1wi3xi 742 1 Hendra Hendra NNP cord-016990-ot1wi3xi 742 2 and and CC cord-016990-ot1wi3xi 742 3 Nipah Nipah NNP cord-016990-ot1wi3xi 742 4 viruses virus NNS cord-016990-ot1wi3xi 742 5 belong belong VBP cord-016990-ot1wi3xi 742 6 to to IN cord-016990-ot1wi3xi 742 7 the the DT cord-016990-ot1wi3xi 742 8 recently recently RB cord-016990-ot1wi3xi 742 9 designated designate VBN cord-016990-ot1wi3xi 742 10 genus genus NN cord-016990-ot1wi3xi 742 11 Henipavirus Henipavirus NNP cord-016990-ot1wi3xi 742 12 within within IN cord-016990-ot1wi3xi 742 13 the the DT cord-016990-ot1wi3xi 742 14 family family NN cord-016990-ot1wi3xi 742 15 Paramyxoviridae Paramyxoviridae NNP cord-016990-ot1wi3xi 742 16 , , , cord-016990-ot1wi3xi 742 17 subfamily subfamily NN cord-016990-ot1wi3xi 742 18 Paramyxovirinae Paramyxovirinae NNP cord-016990-ot1wi3xi 742 19 . . . cord-016990-ot1wi3xi 743 1 Both both DT cord-016990-ot1wi3xi 743 2 viruses virus NNS cord-016990-ot1wi3xi 743 3 are be VBP cord-016990-ot1wi3xi 743 4 nonsegmented nonsegmente VBN cord-016990-ot1wi3xi 743 5 , , , cord-016990-ot1wi3xi 743 6 negative negative JJ cord-016990-ot1wi3xi 743 7 - - HYPH cord-016990-ot1wi3xi 743 8 stranded strand VBN cord-016990-ot1wi3xi 743 9 RNA RNA NNP cord-016990-ot1wi3xi 743 10 viruses virus NNS cord-016990-ot1wi3xi 743 11 composed compose VBN cord-016990-ot1wi3xi 743 12 of of IN cord-016990-ot1wi3xi 743 13 helical helical JJ cord-016990-ot1wi3xi 743 14 nucleocapsids nucleocapsid NNS cord-016990-ot1wi3xi 743 15 enclosed enclose VBN cord-016990-ot1wi3xi 743 16 within within IN cord-016990-ot1wi3xi 743 17 an an DT cord-016990-ot1wi3xi 743 18 envelope envelope NN cord-016990-ot1wi3xi 743 19 to to TO cord-016990-ot1wi3xi 743 20 form form VB cord-016990-ot1wi3xi 743 21 roughly roughly RB cord-016990-ot1wi3xi 743 22 spherical spherical JJ cord-016990-ot1wi3xi 743 23 , , , cord-016990-ot1wi3xi 743 24 pleomorphic pleomorphic JJ cord-016990-ot1wi3xi 743 25 virus virus NN cord-016990-ot1wi3xi 743 26 particles.3IO-312 particles.3io-312 NN cord-016990-ot1wi3xi 744 1 The the DT cord-016990-ot1wi3xi 744 2 structure structure NN cord-016990-ot1wi3xi 744 3 of of IN cord-016990-ot1wi3xi 744 4 their -PRON- PRP$ cord-016990-ot1wi3xi 744 5 genome genome NN cord-016990-ot1wi3xi 744 6 is be VBZ cord-016990-ot1wi3xi 744 7 consistent consistent JJ cord-016990-ot1wi3xi 744 8 with with IN cord-016990-ot1wi3xi 744 9 the the DT cord-016990-ot1wi3xi 744 10 other other JJ cord-016990-ot1wi3xi 744 11 members member NNS cord-016990-ot1wi3xi 744 12 of of IN cord-016990-ot1wi3xi 744 13 the the DT cord-016990-ot1wi3xi 744 14 subfamily subfamily NN cord-016990-ot1wi3xi 744 15 . . . cord-016990-ot1wi3xi 745 1 30 30 CD cord-016990-ot1wi3xi 745 2 Histopathologic Histopathologic NNP cord-016990-ot1wi3xi 745 3 findings finding NNS cord-016990-ot1wi3xi 745 4 in in IN cord-016990-ot1wi3xi 745 5 fatal fatal JJ cord-016990-ot1wi3xi 745 6 cases case NNS cord-016990-ot1wi3xi 745 7 of of IN cord-016990-ot1wi3xi 745 8 Hendra Hendra NNP cord-016990-ot1wi3xi 745 9 and and CC cord-016990-ot1wi3xi 745 10 Nipah Nipah NNP cord-016990-ot1wi3xi 745 11 infections infection NNS cord-016990-ot1wi3xi 745 12 are be VBP cord-016990-ot1wi3xi 745 13 similar similar JJ cord-016990-ot1wi3xi 745 14 with with IN cord-016990-ot1wi3xi 745 15 varying vary VBG cord-016990-ot1wi3xi 745 16 degrees degree NNS cord-016990-ot1wi3xi 745 17 of of IN cord-016990-ot1wi3xi 745 18 CNS CNS NNP cord-016990-ot1wi3xi 745 19 and and CC cord-016990-ot1wi3xi 745 20 respiratory respiratory JJ cord-016990-ot1wi3xi 745 21 tract tract NN cord-016990-ot1wi3xi 745 22 involvement involvement NN cord-016990-ot1wi3xi 745 23 . . . cord-016990-ot1wi3xi 746 1 104 104 CD cord-016990-ot1wi3xi 746 2 , , , cord-016990-ot1wi3xi 746 3 313 313 CD cord-016990-ot1wi3xi 746 4 - - SYM cord-016990-ot1wi3xi 746 5 315 315 CD cord-016990-ot1wi3xi 746 6 Findings finding NNS cord-016990-ot1wi3xi 746 7 include include VBP cord-016990-ot1wi3xi 746 8 a a DT cord-016990-ot1wi3xi 746 9 systemic systemic JJ cord-016990-ot1wi3xi 746 10 vasculitis vasculitis NN cord-016990-ot1wi3xi 746 11 with with IN cord-016990-ot1wi3xi 746 12 extensive extensive JJ cord-016990-ot1wi3xi 746 13 thrombosis thrombosis NN cord-016990-ot1wi3xi 746 14 , , , cord-016990-ot1wi3xi 746 15 endothelial endothelial JJ cord-016990-ot1wi3xi 746 16 cell cell NN cord-016990-ot1wi3xi 746 17 damage damage NN cord-016990-ot1wi3xi 746 18 , , , cord-016990-ot1wi3xi 746 19 necrosis necrosis NN cord-016990-ot1wi3xi 746 20 , , , cord-016990-ot1wi3xi 746 21 and and CC cord-016990-ot1wi3xi 746 22 syncytial syncytial JJ cord-016990-ot1wi3xi 746 23 giant giant JJ cord-016990-ot1wi3xi 746 24 cell cell NN cord-016990-ot1wi3xi 746 25 formation formation NN cord-016990-ot1wi3xi 746 26 in in IN cord-016990-ot1wi3xi 746 27 affected affected JJ cord-016990-ot1wi3xi 746 28 vessels vessel NNS cord-016990-ot1wi3xi 746 29 ( ( -LRB- cord-016990-ot1wi3xi 746 30 Fig Fig NNP cord-016990-ot1wi3xi 746 31 . . . cord-016990-ot1wi3xi 746 32 11.15A 11.15a CD cord-016990-ot1wi3xi 746 33 , , , cord-016990-ot1wi3xi 746 34 B B NNP cord-016990-ot1wi3xi 746 35 , , , cord-016990-ot1wi3xi 746 36 F F NNP cord-016990-ot1wi3xi 746 37 ) ) -RRB- cord-016990-ot1wi3xi 746 38 . . . cord-016990-ot1wi3xi 747 1 Plaques plaque NNS cord-016990-ot1wi3xi 747 2 with with IN cord-016990-ot1wi3xi 747 3 various various JJ cord-016990-ot1wi3xi 747 4 degrees degree NNS cord-016990-ot1wi3xi 747 5 of of IN cord-016990-ot1wi3xi 747 6 necrosis necrosis NN cord-016990-ot1wi3xi 747 7 , , , cord-016990-ot1wi3xi 747 8 in in IN cord-016990-ot1wi3xi 747 9 association association NN cord-016990-ot1wi3xi 747 10 with with IN cord-016990-ot1wi3xi 747 11 inclusion inclusion NN cord-016990-ot1wi3xi 747 12 - - HYPH cord-016990-ot1wi3xi 747 13 bearing bear VBG cord-016990-ot1wi3xi 747 14 neurons neuron NNS cord-016990-ot1wi3xi 747 15 , , , cord-016990-ot1wi3xi 747 16 can can MD cord-016990-ot1wi3xi 747 17 be be VB cord-016990-ot1wi3xi 747 18 found find VBN cord-016990-ot1wi3xi 747 19 in in IN cord-016990-ot1wi3xi 747 20 both both CC cord-016990-ot1wi3xi 747 21 the the DT cord-016990-ot1wi3xi 747 22 gray gray JJ cord-016990-ot1wi3xi 747 23 and and CC cord-016990-ot1wi3xi 747 24 white white JJ cord-016990-ot1wi3xi 747 25 matter matter NN cord-016990-ot1wi3xi 747 26 of of IN cord-016990-ot1wi3xi 747 27 the the DT cord-016990-ot1wi3xi 747 28 CNS CNS NNP cord-016990-ot1wi3xi 747 29 ( ( -LRB- cord-016990-ot1wi3xi 747 30 Fig Fig NNP cord-016990-ot1wi3xi 747 31 . . . cord-016990-ot1wi3xi 747 32 11.15E 11.15e CD cord-016990-ot1wi3xi 747 33 ) ) -RRB- cord-016990-ot1wi3xi 747 34 . . . cord-016990-ot1wi3xi 748 1 Multinucleated multinucleated JJ cord-016990-ot1wi3xi 748 2 giant giant JJ cord-016990-ot1wi3xi 748 3 cells cell NNS cord-016990-ot1wi3xi 748 4 with with IN cord-016990-ot1wi3xi 748 5 intranuclear intranuclear NN cord-016990-ot1wi3xi 748 6 inclusions inclusion NNS cord-016990-ot1wi3xi 748 7 can can MD cord-016990-ot1wi3xi 748 8 occasionally occasionally RB cord-016990-ot1wi3xi 748 9 be be VB cord-016990-ot1wi3xi 748 10 seen see VBN cord-016990-ot1wi3xi 748 11 in in IN cord-016990-ot1wi3xi 748 12 lung lung NN cord-016990-ot1wi3xi 748 13 , , , cord-016990-ot1wi3xi 748 14 spleen spleen NNS cord-016990-ot1wi3xi 748 15 , , , cord-016990-ot1wi3xi 748 16 lymph lymph NN cord-016990-ot1wi3xi 748 17 nodes node NNS cord-016990-ot1wi3xi 748 18 , , , cord-016990-ot1wi3xi 748 19 and and CC cord-016990-ot1wi3xi 748 20 kidneys kidney NNS cord-016990-ot1wi3xi 748 21 ( ( -LRB- cord-016990-ot1wi3xi 748 22 Fig fig NN cord-016990-ot1wi3xi 748 23 . . . cord-016990-ot1wi3xi 748 24 _SP cord-016990-ot1wi3xi 749 1 11 11 CD cord-016990-ot1wi3xi 749 2 .15C .15C NFP cord-016990-ot1wi3xi 749 3 , , , cord-016990-ot1wi3xi 749 4 G G NNP cord-016990-ot1wi3xi 749 5 ) ) -RRB- cord-016990-ot1wi3xi 749 6 . . . cord-016990-ot1wi3xi 750 1 In in IN cord-016990-ot1wi3xi 750 2 the the DT cord-016990-ot1wi3xi 750 3 lung lung NN cord-016990-ot1wi3xi 750 4 , , , cord-016990-ot1wi3xi 750 5 vasculitis vasculitis NN cord-016990-ot1wi3xi 750 6 and and CC cord-016990-ot1wi3xi 750 7 fibrinoid fibrinoid JJ cord-016990-ot1wi3xi 750 8 necrosis necrosis NN cord-016990-ot1wi3xi 750 9 can can MD cord-016990-ot1wi3xi 750 10 be be VB cord-016990-ot1wi3xi 750 11 seen see VBN cord-016990-ot1wi3xi 750 12 in in IN cord-016990-ot1wi3xi 750 13 majority majority NN cord-016990-ot1wi3xi 750 14 of of IN cord-016990-ot1wi3xi 750 15 cases case NNS cord-016990-ot1wi3xi 750 16 . . . cord-016990-ot1wi3xi 751 1 Fibrinoid fibrinoid JJ cord-016990-ot1wi3xi 751 2 necrosis necrosis NN cord-016990-ot1wi3xi 751 3 often often RB cord-016990-ot1wi3xi 751 4 involves involve VBZ cord-016990-ot1wi3xi 751 5 several several JJ cord-016990-ot1wi3xi 751 6 adjacent adjacent JJ cord-016990-ot1wi3xi 751 7 alveoli alveolus NNS cord-016990-ot1wi3xi 751 8 and and CC cord-016990-ot1wi3xi 751 9 is be VBZ cord-016990-ot1wi3xi 751 10 frequently frequently RB cord-016990-ot1wi3xi 751 11 associated associate VBN cord-016990-ot1wi3xi 751 12 with with IN cord-016990-ot1wi3xi 751 13 small small JJ cord-016990-ot1wi3xi 751 14 vessel vessel NN cord-016990-ot1wi3xi 751 15 vasculitis vasculitis NN cord-016990-ot1wi3xi 751 16 . . . cord-016990-ot1wi3xi 752 1 The the DT cord-016990-ot1wi3xi 752 2 multinucleated multinucleated JJ cord-016990-ot1wi3xi 752 3 giant giant JJ cord-016990-ot1wi3xi 752 4 cells cell NNS cord-016990-ot1wi3xi 752 5 with with IN cord-016990-ot1wi3xi 752 6 intranuclear intranuclear NN cord-016990-ot1wi3xi 752 7 inclusions inclusion NNS cord-016990-ot1wi3xi 752 8 are be VBP cord-016990-ot1wi3xi 752 9 usually usually RB cord-016990-ot1wi3xi 752 10 noted note VBN cord-016990-ot1wi3xi 752 11 in in IN cord-016990-ot1wi3xi 752 12 alveolar alveolar JJ cord-016990-ot1wi3xi 752 13 spaces space NNS cord-016990-ot1wi3xi 752 14 adjacent adjacent JJ cord-016990-ot1wi3xi 752 15 to to IN cord-016990-ot1wi3xi 752 16 necrotic necrotic JJ cord-016990-ot1wi3xi 752 17 areas area NNS cord-016990-ot1wi3xi 752 18 . . . cord-016990-ot1wi3xi 753 1 Histopathologic Histopathologic NNP cord-016990-ot1wi3xi 753 2 changes change NNS cord-016990-ot1wi3xi 753 3 of of IN cord-016990-ot1wi3xi 753 4 bronchiolar bronchiolar JJ cord-016990-ot1wi3xi 753 5 epithelium epithelium NN cord-016990-ot1wi3xi 753 6 are be VBP cord-016990-ot1wi3xi 753 7 uncommon uncommon JJ cord-016990-ot1wi3xi 753 8 ; ; : cord-016990-ot1wi3xi 753 9 rarely rarely RB cord-016990-ot1wi3xi 753 10 , , , cord-016990-ot1wi3xi 753 11 the the DT cord-016990-ot1wi3xi 753 12 large large JJ cord-016990-ot1wi3xi 753 13 bronchi bronchi NN cord-016990-ot1wi3xi 753 14 may may MD cord-016990-ot1wi3xi 753 15 show show VB cord-016990-ot1wi3xi 753 16 transmural transmural JJ cord-016990-ot1wi3xi 753 17 inflammation inflammation NN cord-016990-ot1wi3xi 753 18 and and CC cord-016990-ot1wi3xi 753 19 ulceration ulceration NN cord-016990-ot1wi3xi 753 20 . . . cord-016990-ot1wi3xi 754 1 Widespread widespread JJ cord-016990-ot1wi3xi 754 2 presence presence NN cord-016990-ot1wi3xi 754 3 of of IN cord-016990-ot1wi3xi 754 4 Nipah Nipah NNP cord-016990-ot1wi3xi 754 5 virus virus NN cord-016990-ot1wi3xi 754 6 antigens antigen NNS cord-016990-ot1wi3xi 754 7 can can MD cord-016990-ot1wi3xi 754 8 be be VB cord-016990-ot1wi3xi 754 9 seen see VBN cord-016990-ot1wi3xi 754 10 by by IN cord-016990-ot1wi3xi 754 11 IHC IHC NNP cord-016990-ot1wi3xi 754 12 in in IN cord-016990-ot1wi3xi 754 13 endothelial endothelial JJ cord-016990-ot1wi3xi 754 14 and and CC cord-016990-ot1wi3xi 754 15 smooth smooth JJ cord-016990-ot1wi3xi 754 16 muscle muscle NN cord-016990-ot1wi3xi 754 17 cells cell NNS cord-016990-ot1wi3xi 754 18 of of IN cord-016990-ot1wi3xi 754 19 blood blood NN cord-016990-ot1wi3xi 754 20 vessels vessel NNS cord-016990-ot1wi3xi 754 21 as as RB cord-016990-ot1wi3xi 754 22 well well RB cord-016990-ot1wi3xi 754 23 as as IN cord-016990-ot1wi3xi 754 24 in in IN cord-016990-ot1wi3xi 754 25 various various JJ cord-016990-ot1wi3xi 754 26 parenchymal parenchymal NN cord-016990-ot1wi3xi 754 27 cells cell NNS cord-016990-ot1wi3xi 754 28 ( ( -LRB- cord-016990-ot1wi3xi 754 29 Fig fig NN cord-016990-ot1wi3xi 754 30 . . . cord-016990-ot1wi3xi 754 31 11.15D 11.15d CD cord-016990-ot1wi3xi 754 32 ) ) -RRB- cord-016990-ot1wi3xi 754 33 . . . cord-016990-ot1wi3xi 755 1 The the DT cord-016990-ot1wi3xi 755 2 diagnosis diagnosis NN cord-016990-ot1wi3xi 755 3 of of IN cord-016990-ot1wi3xi 755 4 Nipah Nipah NNP cord-016990-ot1wi3xi 755 5 virus virus NN cord-016990-ot1wi3xi 755 6 infection infection NN cord-016990-ot1wi3xi 755 7 , , , cord-016990-ot1wi3xi 755 8 suspected suspect VBN cord-016990-ot1wi3xi 755 9 by by IN cord-016990-ot1wi3xi 755 10 patient patient JJ cord-016990-ot1wi3xi 755 11 history history NN cord-016990-ot1wi3xi 755 12 and and CC cord-016990-ot1wi3xi 755 13 clinical clinical JJ cord-016990-ot1wi3xi 755 14 manifestations manifestation NNS cord-016990-ot1wi3xi 755 15 , , , cord-016990-ot1wi3xi 755 16 can can MD cord-016990-ot1wi3xi 755 17 be be VB cord-016990-ot1wi3xi 755 18 supported support VBN cord-016990-ot1wi3xi 755 19 by by IN cord-016990-ot1wi3xi 755 20 characteristic characteristic JJ cord-016990-ot1wi3xi 755 21 histopathologic histopathologic JJ cord-016990-ot1wi3xi 755 22 findings finding NNS cord-016990-ot1wi3xi 755 23 . . . cord-016990-ot1wi3xi 756 1 From from IN cord-016990-ot1wi3xi 756 2 a a DT cord-016990-ot1wi3xi 756 3 diagnostic diagnostic JJ cord-016990-ot1wi3xi 756 4 standpoint standpoint NN cord-016990-ot1wi3xi 756 5 , , , cord-016990-ot1wi3xi 756 6 perhaps perhaps RB cord-016990-ot1wi3xi 756 7 the the DT cord-016990-ot1wi3xi 756 8 most most RBS cord-016990-ot1wi3xi 756 9 unique unique JJ cord-016990-ot1wi3xi 756 10 histopathologic histopathologic JJ cord-016990-ot1wi3xi 756 11 finding finding NN cord-016990-ot1wi3xi 756 12 is be VBZ cord-016990-ot1wi3xi 756 13 the the DT cord-016990-ot1wi3xi 756 14 presence presence NN cord-016990-ot1wi3xi 756 15 of of IN cord-016990-ot1wi3xi 756 16 syncytial syncytial JJ cord-016990-ot1wi3xi 756 17 and and CC cord-016990-ot1wi3xi 756 18 parenchymal parenchymal JJ cord-016990-ot1wi3xi 756 19 multinucleated multinucleate VBD cord-016990-ot1wi3xi 756 20 endothelial endothelial JJ cord-016990-ot1wi3xi 756 21 cells cell NNS cord-016990-ot1wi3xi 756 22 . . . cord-016990-ot1wi3xi 757 1 This this DT cord-016990-ot1wi3xi 757 2 feature feature NN cord-016990-ot1wi3xi 757 3 457 457 CD cord-016990-ot1wi3xi 757 4 occurs occur NNS cord-016990-ot1wi3xi 757 5 in in IN cord-016990-ot1wi3xi 757 6 only only RB cord-016990-ot1wi3xi 757 7 approximately approximately RB cord-016990-ot1wi3xi 757 8 one one CD cord-016990-ot1wi3xi 757 9 fourth fourth NN cord-016990-ot1wi3xi 757 10 of of IN cord-016990-ot1wi3xi 757 11 the the DT cord-016990-ot1wi3xi 757 12 cases case NNS cord-016990-ot1wi3xi 757 13 and and CC cord-016990-ot1wi3xi 757 14 can can MD cord-016990-ot1wi3xi 757 15 not not RB cord-016990-ot1wi3xi 757 16 be be VB cord-016990-ot1wi3xi 757 17 used use VBN cord-016990-ot1wi3xi 757 18 as as IN cord-016990-ot1wi3xi 757 19 a a DT cord-016990-ot1wi3xi 757 20 sensitive sensitive JJ cord-016990-ot1wi3xi 757 21 criterion criterion NN cord-016990-ot1wi3xi 757 22 for for IN cord-016990-ot1wi3xi 757 23 the the DT cord-016990-ot1wi3xi 757 24 diagnosis diagnosis NN cord-016990-ot1wi3xi 757 25 of of IN cord-016990-ot1wi3xi 757 26 Henipah Henipah NNP cord-016990-ot1wi3xi 757 27 virus virus NN cord-016990-ot1wi3xi 757 28 infections infection NNS cord-016990-ot1wi3xi 757 29 ; ; : cord-016990-ot1wi3xi 757 30 furthermore furthermore RB cord-016990-ot1wi3xi 757 31 , , , cord-016990-ot1wi3xi 757 32 these these DT cord-016990-ot1wi3xi 757 33 cells cell NNS cord-016990-ot1wi3xi 757 34 can can MD cord-016990-ot1wi3xi 757 35 also also RB cord-016990-ot1wi3xi 757 36 be be VB cord-016990-ot1wi3xi 757 37 seen see VBN cord-016990-ot1wi3xi 757 38 in in IN cord-016990-ot1wi3xi 757 39 measles measles NN cord-016990-ot1wi3xi 757 40 virus virus NN cord-016990-ot1wi3xi 757 41 , , , cord-016990-ot1wi3xi 757 42 RSV RSV NNP cord-016990-ot1wi3xi 757 43 , , , cord-016990-ot1wi3xi 757 44 HPIV HPIV NNP cord-016990-ot1wi3xi 757 45 , , , cord-016990-ot1wi3xi 757 46 herpesviruses herpesviruses NNP cord-016990-ot1wi3xi 757 47 , , , cord-016990-ot1wi3xi 757 48 and and CC cord-016990-ot1wi3xi 757 49 other other JJ cord-016990-ot1wi3xi 757 50 infections infection NNS cord-016990-ot1wi3xi 757 51 . . . cord-016990-ot1wi3xi 758 1 Unequivocal unequivocal JJ cord-016990-ot1wi3xi 758 2 diagnosis diagnosis NN cord-016990-ot1wi3xi 758 3 can can MD cord-016990-ot1wi3xi 758 4 be be VB cord-016990-ot1wi3xi 758 5 made make VBN cord-016990-ot1wi3xi 758 6 only only RB cord-016990-ot1wi3xi 758 7 by by IN cord-016990-ot1wi3xi 758 8 laboratory laboratory NN cord-016990-ot1wi3xi 758 9 tests test NNS cord-016990-ot1wi3xi 758 10 such such JJ cord-016990-ot1wi3xi 758 11 as as IN cord-016990-ot1wi3xi 758 12 IHC IHC NNP cord-016990-ot1wi3xi 758 13 , , , cord-016990-ot1wi3xi 758 14 cell cell NN cord-016990-ot1wi3xi 758 15 culture culture NN cord-016990-ot1wi3xi 758 16 isolation isolation NN cord-016990-ot1wi3xi 758 17 , , , cord-016990-ot1wi3xi 758 18 PCR PCR NNP cord-016990-ot1wi3xi 758 19 , , , cord-016990-ot1wi3xi 758 20 or or CC cord-016990-ot1wi3xi 758 21 serology.l04,304,316 serology.l04,304,316 NNP cord-016990-ot1wi3xi 758 22 - - SYM cord-016990-ot1wi3xi 758 23 319 319 CD cord-016990-ot1wi3xi 759 1 The the DT cord-016990-ot1wi3xi 759 2 parvoviruses parvovirus NNS cord-016990-ot1wi3xi 759 3 are be VBP cord-016990-ot1wi3xi 759 4 small small JJ cord-016990-ot1wi3xi 759 5 ( ( -LRB- cord-016990-ot1wi3xi 759 6 18 18 CD cord-016990-ot1wi3xi 759 7 to to TO cord-016990-ot1wi3xi 759 8 26 26 CD cord-016990-ot1wi3xi 759 9 nm nm NN cord-016990-ot1wi3xi 759 10 ) ) -RRB- cord-016990-ot1wi3xi 759 11 naked naked JJ cord-016990-ot1wi3xi 759 12 viruses virus NNS cord-016990-ot1wi3xi 759 13 that that WDT cord-016990-ot1wi3xi 759 14 possess possess VBP cord-016990-ot1wi3xi 759 15 a a DT cord-016990-ot1wi3xi 759 16 single single RB cord-016990-ot1wi3xi 759 17 - - HYPH cord-016990-ot1wi3xi 759 18 stranded strand VBN cord-016990-ot1wi3xi 759 19 DNA dna NN cord-016990-ot1wi3xi 759 20 genome genome NN cord-016990-ot1wi3xi 759 21 and and CC cord-016990-ot1wi3xi 759 22 require require VBP cord-016990-ot1wi3xi 759 23 actively actively RB cord-016990-ot1wi3xi 759 24 dividing divide VBG cord-016990-ot1wi3xi 759 25 cells cell NNS cord-016990-ot1wi3xi 759 26 to to TO cord-016990-ot1wi3xi 759 27 complete complete VB cord-016990-ot1wi3xi 759 28 the the DT cord-016990-ot1wi3xi 759 29 viral viral JJ cord-016990-ot1wi3xi 759 30 replication replication NN cord-016990-ot1wi3xi 759 31 cycle cycle NN cord-016990-ot1wi3xi 759 32 . . . cord-016990-ot1wi3xi 760 1 In in IN cord-016990-ot1wi3xi 760 2 2005 2005 CD cord-016990-ot1wi3xi 760 3 , , , cord-016990-ot1wi3xi 760 4 Allander Allander NNP cord-016990-ot1wi3xi 760 5 et et NNP cord-016990-ot1wi3xi 760 6 a1 a1 NNP cord-016990-ot1wi3xi 760 7 . . . cord-016990-ot1wi3xi 761 1 320 320 CD cord-016990-ot1wi3xi 761 2 identified identify VBD cord-016990-ot1wi3xi 761 3 a a DT cord-016990-ot1wi3xi 761 4 new new JJ cord-016990-ot1wi3xi 761 5 parvovirus parvovirus NN cord-016990-ot1wi3xi 761 6 ( ( -LRB- cord-016990-ot1wi3xi 761 7 genus genus NN cord-016990-ot1wi3xi 761 8 Bocavirus Bocavirus NNP cord-016990-ot1wi3xi 761 9 ) ) -RRB- cord-016990-ot1wi3xi 761 10 associated associate VBN cord-016990-ot1wi3xi 761 11 with with IN cord-016990-ot1wi3xi 761 12 lower low JJR cord-016990-ot1wi3xi 761 13 respiratory respiratory JJ cord-016990-ot1wi3xi 761 14 tract tract NN cord-016990-ot1wi3xi 761 15 infections infection NNS cord-016990-ot1wi3xi 761 16 in in IN cord-016990-ot1wi3xi 761 17 children child NNS cord-016990-ot1wi3xi 761 18 ; ; : cord-016990-ot1wi3xi 761 19 however however RB cord-016990-ot1wi3xi 761 20 , , , cord-016990-ot1wi3xi 761 21 there there EX cord-016990-ot1wi3xi 761 22 is be VBZ cord-016990-ot1wi3xi 761 23 no no DT cord-016990-ot1wi3xi 761 24 information information NN cord-016990-ot1wi3xi 761 25 as as RB cord-016990-ot1wi3xi 761 26 yet yet RB cord-016990-ot1wi3xi 761 27 that that WDT cord-016990-ot1wi3xi 761 28 describes describe VBZ cord-016990-ot1wi3xi 761 29 specific specific JJ cord-016990-ot1wi3xi 761 30 pulmonary pulmonary JJ cord-016990-ot1wi3xi 761 31 pathology pathology NN cord-016990-ot1wi3xi 761 32 attributed attribute VBN cord-016990-ot1wi3xi 761 33 to to IN cord-016990-ot1wi3xi 761 34 this this DT cord-016990-ot1wi3xi 761 35 newly newly RB cord-016990-ot1wi3xi 761 36 identified identify VBN cord-016990-ot1wi3xi 761 37 agent agent NN cord-016990-ot1wi3xi 761 38 . . . cord-016990-ot1wi3xi 762 1 On on IN cord-016990-ot1wi3xi 762 2 the the DT cord-016990-ot1wi3xi 762 3 other other JJ cord-016990-ot1wi3xi 762 4 hand hand NN cord-016990-ot1wi3xi 762 5 , , , cord-016990-ot1wi3xi 762 6 human human JJ cord-016990-ot1wi3xi 762 7 parvovirus parvovirus NN cord-016990-ot1wi3xi 762 8 B19 B19 NNP cord-016990-ot1wi3xi 762 9 , , , cord-016990-ot1wi3xi 762 10 a a DT cord-016990-ot1wi3xi 762 11 member member NN cord-016990-ot1wi3xi 762 12 of of IN cord-016990-ot1wi3xi 762 13 the the DT cord-016990-ot1wi3xi 762 14 genus genus NN cord-016990-ot1wi3xi 762 15 Erythrovirus Erythrovirus NNP cord-016990-ot1wi3xi 762 16 , , , cord-016990-ot1wi3xi 762 17 has have VBZ cord-016990-ot1wi3xi 762 18 long long RB cord-016990-ot1wi3xi 762 19 been be VBN cord-016990-ot1wi3xi 762 20 known know VBN cord-016990-ot1wi3xi 762 21 to to TO cord-016990-ot1wi3xi 762 22 cause cause VB cord-016990-ot1wi3xi 762 23 human human JJ cord-016990-ot1wi3xi 762 24 disease disease NN cord-016990-ot1wi3xi 762 25 and and CC cord-016990-ot1wi3xi 762 26 has have VBZ cord-016990-ot1wi3xi 762 27 been be VBN cord-016990-ot1wi3xi 762 28 well well RB cord-016990-ot1wi3xi 762 29 studied study VBN cord-016990-ot1wi3xi 762 30 . . . cord-016990-ot1wi3xi 763 1 321 321 CD cord-016990-ot1wi3xi 763 2 , , , cord-016990-ot1wi3xi 763 3 322 322 CD cord-016990-ot1wi3xi 763 4 The the DT cord-016990-ot1wi3xi 763 5 most most RBS cord-016990-ot1wi3xi 763 6 commonly commonly RB cord-016990-ot1wi3xi 763 7 recognized recognize VBN cord-016990-ot1wi3xi 763 8 manifestation manifestation NN cord-016990-ot1wi3xi 763 9 of of IN cord-016990-ot1wi3xi 763 10 B19 B19 NNP cord-016990-ot1wi3xi 763 11 infections infection NNS cord-016990-ot1wi3xi 763 12 is be VBZ cord-016990-ot1wi3xi 763 13 erythema erythema JJ cord-016990-ot1wi3xi 763 14 infectiosum infectiosum NN cord-016990-ot1wi3xi 763 15 , , , cord-016990-ot1wi3xi 763 16 and and CC cord-016990-ot1wi3xi 763 17 approximately approximately RB cord-016990-ot1wi3xi 763 18 one one CD cord-016990-ot1wi3xi 763 19 third third NN cord-016990-ot1wi3xi 763 20 of of IN cord-016990-ot1wi3xi 763 21 the the DT cord-016990-ot1wi3xi 763 22 cases case NNS cord-016990-ot1wi3xi 763 23 of of IN cord-016990-ot1wi3xi 763 24 maternal maternal JJ cord-016990-ot1wi3xi 763 25 parvovirus parvovirus NN cord-016990-ot1wi3xi 763 26 infections infection NNS cord-016990-ot1wi3xi 763 27 result result VBP cord-016990-ot1wi3xi 763 28 in in IN cord-016990-ot1wi3xi 763 29 intrauterine intrauterine JJ cord-016990-ot1wi3xi 763 30 parvovirus parvovirus NN cord-016990-ot1wi3xi 763 31 B19 B19 NNP cord-016990-ot1wi3xi 763 32 infections infection NNS cord-016990-ot1wi3xi 763 33 . . . cord-016990-ot1wi3xi 764 1 This this DT cord-016990-ot1wi3xi 764 2 places place VBZ cord-016990-ot1wi3xi 764 3 the the DT cord-016990-ot1wi3xi 764 4 fetus fetus NN cord-016990-ot1wi3xi 764 5 at at IN cord-016990-ot1wi3xi 764 6 increased increase VBN cord-016990-ot1wi3xi 764 7 risk risk NN cord-016990-ot1wi3xi 764 8 for for IN cord-016990-ot1wi3xi 764 9 severe severe JJ cord-016990-ot1wi3xi 764 10 anemia anemia NN cord-016990-ot1wi3xi 764 11 , , , cord-016990-ot1wi3xi 764 12 hydrops hydrop NNS cord-016990-ot1wi3xi 764 13 , , , cord-016990-ot1wi3xi 764 14 and and CC cord-016990-ot1wi3xi 764 15 death death NN cord-016990-ot1wi3xi 764 16 . . . cord-016990-ot1wi3xi 765 1 Hydrops Hydrops NNP cord-016990-ot1wi3xi 765 2 fetalis fetalis NNP cord-016990-ot1wi3xi 765 3 is be VBZ cord-016990-ot1wi3xi 765 4 the the DT cord-016990-ot1wi3xi 765 5 most most RBS cord-016990-ot1wi3xi 765 6 commonly commonly RB cord-016990-ot1wi3xi 765 7 recognized recognize VBN cord-016990-ot1wi3xi 765 8 complication complication NN cord-016990-ot1wi3xi 765 9 of of IN cord-016990-ot1wi3xi 765 10 intrauterine intrauterine JJ cord-016990-ot1wi3xi 765 11 parvovirus parvovirus NN cord-016990-ot1wi3xi 765 12 infection infection NN cord-016990-ot1wi3xi 765 13 , , , cord-016990-ot1wi3xi 765 14 accounting account VBG cord-016990-ot1wi3xi 765 15 for for IN cord-016990-ot1wi3xi 765 16 4 4 CD cord-016990-ot1wi3xi 765 17 % % NN cord-016990-ot1wi3xi 765 18 to to TO cord-016990-ot1wi3xi 765 19 18 18 CD cord-016990-ot1wi3xi 765 20 % % NN cord-016990-ot1wi3xi 765 21 of of IN cord-016990-ot1wi3xi 765 22 all all DT cord-016990-ot1wi3xi 765 23 cases case NNS cord-016990-ot1wi3xi 765 24 of of IN cord-016990-ot1wi3xi 765 25 nonimmune nonimmune JJ cord-016990-ot1wi3xi 765 26 hydrops hydrops NNP cord-016990-ot1wi3xi 765 27 . . . cord-016990-ot1wi3xi 766 1 Cases case NNS cord-016990-ot1wi3xi 766 2 tend tend VBP cord-016990-ot1wi3xi 766 3 to to TO cord-016990-ot1wi3xi 766 4 be be VB cord-016990-ot1wi3xi 766 5 clustered cluster VBN cord-016990-ot1wi3xi 766 6 during during IN cord-016990-ot1wi3xi 766 7 community community NN cord-016990-ot1wi3xi 766 8 outbreaks outbreak NNS cord-016990-ot1wi3xi 766 9 of of IN cord-016990-ot1wi3xi 766 10 erythema erythema NN cord-016990-ot1wi3xi 766 11 infectiosum infectiosum NN cord-016990-ot1wi3xi 766 12 . . . cord-016990-ot1wi3xi 767 1 321 321 CD cord-016990-ot1wi3xi 767 2 . . . cord-016990-ot1wi3xi 768 1 3 3 CD cord-016990-ot1wi3xi 768 2 22 22 CD cord-016990-ot1wi3xi 768 3 Pathophysiologic Pathophysiologic NNP cord-016990-ot1wi3xi 768 4 effects effect NNS cord-016990-ot1wi3xi 768 5 and and CC cord-016990-ot1wi3xi 768 6 histopathologic histopathologic JJ cord-016990-ot1wi3xi 768 7 findings finding NNS cord-016990-ot1wi3xi 768 8 are be VBP cord-016990-ot1wi3xi 768 9 a a DT cord-016990-ot1wi3xi 768 10 result result NN cord-016990-ot1wi3xi 768 11 of of IN cord-016990-ot1wi3xi 768 12 the the DT cord-016990-ot1wi3xi 768 13 tropism tropism NN cord-016990-ot1wi3xi 768 14 of of IN cord-016990-ot1wi3xi 768 15 B19 B19 NNP cord-016990-ot1wi3xi 768 16 parvovirus parvovirus NN cord-016990-ot1wi3xi 768 17 for for IN cord-016990-ot1wi3xi 768 18 erythroid erythroid NN cord-016990-ot1wi3xi 768 19 precursor precursor NN cord-016990-ot1wi3xi 768 20 cells cell NNS cord-016990-ot1wi3xi 768 21 . . . cord-016990-ot1wi3xi 769 1 Villi Villi NNP cord-016990-ot1wi3xi 769 2 from from IN cord-016990-ot1wi3xi 769 3 placentas placenta NNS cord-016990-ot1wi3xi 769 4 from from IN cord-016990-ot1wi3xi 769 5 patients patient NNS cord-016990-ot1wi3xi 769 6 with with IN cord-016990-ot1wi3xi 769 7 Bl9-associated Bl9-associated NNP cord-016990-ot1wi3xi 769 8 nonimmune nonimmune JJ cord-016990-ot1wi3xi 769 9 hydrops hydrop NNS cord-016990-ot1wi3xi 769 10 are be VBP cord-016990-ot1wi3xi 769 11 edematous edematous JJ cord-016990-ot1wi3xi 769 12 , , , cord-016990-ot1wi3xi 769 13 and and CC cord-016990-ot1wi3xi 769 14 fetal fetal JJ cord-016990-ot1wi3xi 769 15 capillaries capillary NNS cord-016990-ot1wi3xi 769 16 show show VBP cord-016990-ot1wi3xi 769 17 numerous numerous JJ cord-016990-ot1wi3xi 769 18 nucleated nucleated JJ cord-016990-ot1wi3xi 769 19 erythroid erythroid JJ cord-016990-ot1wi3xi 769 20 precursors precursor NNS cord-016990-ot1wi3xi 769 21 , , , cord-016990-ot1wi3xi 769 22 some some DT cord-016990-ot1wi3xi 769 23 containing contain VBG cord-016990-ot1wi3xi 769 24 parvovirus parvovirus NN cord-016990-ot1wi3xi 769 25 inclusions inclusion NNS cord-016990-ot1wi3xi 769 26 . . . cord-016990-ot1wi3xi 770 1 The the DT cord-016990-ot1wi3xi 770 2 infected infected JJ cord-016990-ot1wi3xi 770 3 cells cell NNS cord-016990-ot1wi3xi 770 4 with with IN cord-016990-ot1wi3xi 770 5 eosinophilic eosinophilic JJ cord-016990-ot1wi3xi 770 6 " " `` cord-016990-ot1wi3xi 770 7 ground ground NN cord-016990-ot1wi3xi 770 8 glass glass NN cord-016990-ot1wi3xi 770 9 " " '' cord-016990-ot1wi3xi 770 10 intranuclear intranuclear NN cord-016990-ot1wi3xi 770 11 inclusions inclusion NNS cord-016990-ot1wi3xi 770 12 and and CC cord-016990-ot1wi3xi 770 13 ring ring NN cord-016990-ot1wi3xi 770 14 - - HYPH cord-016990-ot1wi3xi 770 15 like like JJ cord-016990-ot1wi3xi 770 16 margination margination NN cord-016990-ot1wi3xi 770 17 of of IN cord-016990-ot1wi3xi 770 18 nuclear nuclear JJ cord-016990-ot1wi3xi 770 19 chromatin chromatin NNP cord-016990-ot1wi3xi 770 20 are be VBP cord-016990-ot1wi3xi 770 21 easily easily RB cord-016990-ot1wi3xi 770 22 recognized recognize VBN cord-016990-ot1wi3xi 770 23 and and CC cord-016990-ot1wi3xi 770 24 in in IN cord-016990-ot1wi3xi 770 25 the the DT cord-016990-ot1wi3xi 770 26 context context NN cord-016990-ot1wi3xi 770 27 of of IN cord-016990-ot1wi3xi 770 28 a a DT cord-016990-ot1wi3xi 770 29 hydropic hydropic NN cord-016990-ot1wi3xi 770 30 fetus fetus NN cord-016990-ot1wi3xi 770 31 are be VBP cord-016990-ot1wi3xi 770 32 pathognomonic pathognomonic JJ cord-016990-ot1wi3xi 770 33 of of IN cord-016990-ot1wi3xi 770 34 B19 B19 NNP cord-016990-ot1wi3xi 770 35 infection infection NN cord-016990-ot1wi3xi 770 36 . . . cord-016990-ot1wi3xi 771 1 The the DT cord-016990-ot1wi3xi 771 2 liver liver NN cord-016990-ot1wi3xi 771 3 is be VBZ cord-016990-ot1wi3xi 771 4 the the DT cord-016990-ot1wi3xi 771 5 major major JJ cord-016990-ot1wi3xi 771 6 site site NN cord-016990-ot1wi3xi 771 7 of of IN cord-016990-ot1wi3xi 771 8 blood blood NN cord-016990-ot1wi3xi 771 9 production production NN cord-016990-ot1wi3xi 771 10 in in IN cord-016990-ot1wi3xi 771 11 the the DT cord-016990-ot1wi3xi 771 12 fetus fetus NN cord-016990-ot1wi3xi 771 13 and and CC cord-016990-ot1wi3xi 771 14 the the DT cord-016990-ot1wi3xi 771 15 principal principal JJ cord-016990-ot1wi3xi 771 16 organ organ NN cord-016990-ot1wi3xi 771 17 affected affect VBN cord-016990-ot1wi3xi 771 18 by by IN cord-016990-ot1wi3xi 771 19 intrauterine intrauterine JJ cord-016990-ot1wi3xi 771 20 B19 B19 NNP cord-016990-ot1wi3xi 771 21 infection infection NN cord-016990-ot1wi3xi 771 22 . . . cord-016990-ot1wi3xi 772 1 Inclusion inclusion NN cord-016990-ot1wi3xi 772 2 - - HYPH cord-016990-ot1wi3xi 772 3 bearing bear VBG cord-016990-ot1wi3xi 772 4 nucleated nucleated JJ cord-016990-ot1wi3xi 772 5 erythrocytes erythrocyte NNS cord-016990-ot1wi3xi 772 6 can can MD cord-016990-ot1wi3xi 772 7 also also RB cord-016990-ot1wi3xi 772 8 be be VB cord-016990-ot1wi3xi 772 9 frequently frequently RB cord-016990-ot1wi3xi 772 10 identified identify VBN cord-016990-ot1wi3xi 772 11 in in IN cord-016990-ot1wi3xi 772 12 the the DT cord-016990-ot1wi3xi 772 13 lung lung NN cord-016990-ot1wi3xi 772 14 , , , cord-016990-ot1wi3xi 772 15 making make VBG cord-016990-ot1wi3xi 772 16 histopathologic histopathologic JJ cord-016990-ot1wi3xi 772 17 examination examination NN cord-016990-ot1wi3xi 772 18 of of IN cord-016990-ot1wi3xi 772 19 this this DT cord-016990-ot1wi3xi 772 20 organ organ NN cord-016990-ot1wi3xi 772 21 a a DT cord-016990-ot1wi3xi 772 22 worthwhile worthwhile JJ cord-016990-ot1wi3xi 772 23 endeavor endeavor NN cord-016990-ot1wi3xi 772 24 for for IN cord-016990-ot1wi3xi 772 25 confirming confirm VBG cord-016990-ot1wi3xi 772 26 the the DT cord-016990-ot1wi3xi 772 27 diagnosis diagnosis NN cord-016990-ot1wi3xi 772 28 of of IN cord-016990-ot1wi3xi 772 29 intrauterine intrauterine JJ cord-016990-ot1wi3xi 772 30 BI9 BI9 NNP cord-016990-ot1wi3xi 772 31 infection infection NN cord-016990-ot1wi3xi 773 1 ( ( -LRB- cord-016990-ot1wi3xi 773 2 Fig Fig NNP cord-016990-ot1wi3xi 773 3 . . . cord-016990-ot1wi3xi 773 4 _SP cord-016990-ot1wi3xi 773 5 Il Il NNP cord-016990-ot1wi3xi 773 6 . . . cord-016990-ot1wi3xi 774 1 I6A i6a JJ cord-016990-ot1wi3xi 774 2 , , , cord-016990-ot1wi3xi 774 3 B B NNP cord-016990-ot1wi3xi 774 4 ) ) -RRB- cord-016990-ot1wi3xi 774 5 .323 .323 CD cord-016990-ot1wi3xi 774 6 - - SYM cord-016990-ot1wi3xi 774 7 332 332 CD cord-016990-ot1wi3xi 775 1 However however RB cord-016990-ot1wi3xi 775 2 , , , cord-016990-ot1wi3xi 775 3 these these DT cord-016990-ot1wi3xi 775 4 cells cell NNS cord-016990-ot1wi3xi 775 5 may may MD cord-016990-ot1wi3xi 775 6 be be VB cord-016990-ot1wi3xi 775 7 infrequent infrequent JJ cord-016990-ot1wi3xi 775 8 and and CC cord-016990-ot1wi3xi 775 9 irregularly irregularly RB cord-016990-ot1wi3xi 775 10 distributed distribute VBN cord-016990-ot1wi3xi 775 11 , , , cord-016990-ot1wi3xi 775 12 requiring require VBG cord-016990-ot1wi3xi 775 13 examination examination NN cord-016990-ot1wi3xi 775 14 of of IN cord-016990-ot1wi3xi 775 15 multiple multiple JJ cord-016990-ot1wi3xi 775 16 sections section NNS cord-016990-ot1wi3xi 775 17 and and CC cord-016990-ot1wi3xi 775 18 use use NN cord-016990-ot1wi3xi 775 19 of of IN cord-016990-ot1wi3xi 775 20 IHC IHC NNP cord-016990-ot1wi3xi 775 21 to to TO cord-016990-ot1wi3xi 775 22 confirm confirm VB cord-016990-ot1wi3xi 775 23 the the DT cord-016990-ot1wi3xi 775 24 diagnosis diagnosis NN cord-016990-ot1wi3xi 775 25 ( ( -LRB- cord-016990-ot1wi3xi 775 26 Fig.l1.16C fig.l1.16c NN cord-016990-ot1wi3xi 775 27 , , , cord-016990-ot1wi3xi 775 28 D D NNP cord-016990-ot1wi3xi 775 29 ) ) -RRB- cord-016990-ot1wi3xi 775 30 . . . cord-016990-ot1wi3xi 775 31 _SP cord-016990-ot1wi3xi 776 1 The the DT cord-016990-ot1wi3xi 776 2 combination combination NN cord-016990-ot1wi3xi 776 3 of of IN cord-016990-ot1wi3xi 776 4 fever fever NN cord-016990-ot1wi3xi 776 5 and and CC cord-016990-ot1wi3xi 776 6 hemorrhage hemorrhage NN cord-016990-ot1wi3xi 776 7 can can MD cord-016990-ot1wi3xi 776 8 be be VB cord-016990-ot1wi3xi 776 9 caused cause VBN cord-016990-ot1wi3xi 776 10 by by IN cord-016990-ot1wi3xi 776 11 different different JJ cord-016990-ot1wi3xi 776 12 viruses virus NNS cord-016990-ot1wi3xi 776 13 , , , cord-016990-ot1wi3xi 776 14 rickettsiae rickettsiae NN cord-016990-ot1wi3xi 776 15 , , , cord-016990-ot1wi3xi 776 16 bacteria bacteria NNS cord-016990-ot1wi3xi 776 17 , , , cord-016990-ot1wi3xi 776 18 protozoa protozoan NNS cord-016990-ot1wi3xi 776 19 , , , cord-016990-ot1wi3xi 776 20 and and CC cord-016990-ot1wi3xi 776 21 fungi fungus NNS cord-016990-ot1wi3xi 776 22 . . . cord-016990-ot1wi3xi 777 1 However however RB cord-016990-ot1wi3xi 777 2 , , , cord-016990-ot1wi3xi 777 3 the the DT cord-016990-ot1wi3xi 777 4 term term NN cord-016990-ot1wi3xi 777 5 viral viral JJ cord-016990-ot1wi3xi 777 6 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 777 7 fever fever NN cord-016990-ot1wi3xi 777 8 ( ( -LRB- cord-016990-ot1wi3xi 777 9 VHF VHF NNP cord-016990-ot1wi3xi 777 10 ) ) -RRB- cord-016990-ot1wi3xi 777 11 is be VBZ cord-016990-ot1wi3xi 777 12 usually usually RB cord-016990-ot1wi3xi 777 13 reserved reserve VBN cord-016990-ot1wi3xi 777 14 for for IN cord-016990-ot1wi3xi 777 15 systemic systemic JJ cord-016990-ot1wi3xi 777 16 infections infection NNS cord-016990-ot1wi3xi 777 17 characterized characterize VBN cord-016990-ot1wi3xi 777 18 by by IN cord-016990-ot1wi3xi 777 19 fever fever NN cord-016990-ot1wi3xi 777 20 and and CC cord-016990-ot1wi3xi 777 21 hemorrhage hemorrhage NN cord-016990-ot1wi3xi 777 22 caused cause VBN cord-016990-ot1wi3xi 777 23 by by IN cord-016990-ot1wi3xi 777 24 a a DT cord-016990-ot1wi3xi 777 25 special special JJ cord-016990-ot1wi3xi 777 26 group group NN cord-016990-ot1wi3xi 777 27 of of IN cord-016990-ot1wi3xi 777 28 viruses virus NNS cord-016990-ot1wi3xi 777 29 transmitted transmit VBN cord-016990-ot1wi3xi 777 30 to to IN cord-016990-ot1wi3xi 777 31 humans human NNS cord-016990-ot1wi3xi 777 32 by by IN cord-016990-ot1wi3xi 777 33 arthropods arthropod NNS cord-016990-ot1wi3xi 777 34 and and CC cord-016990-ot1wi3xi 777 35 rodents rodent NNS cord-016990-ot1wi3xi 777 36 . . . cord-016990-ot1wi3xi 778 1 The the DT cord-016990-ot1wi3xi 778 2 VHFs vhf NNS cord-016990-ot1wi3xi 778 3 are be VBP cord-016990-ot1wi3xi 778 4 febrile febrile JJ cord-016990-ot1wi3xi 778 5 illnesses illness NNS cord-016990-ot1wi3xi 778 6 characterized characterize VBN cord-016990-ot1wi3xi 778 7 by by IN cord-016990-ot1wi3xi 778 8 abnormal abnormal JJ cord-016990-ot1wi3xi 778 9 vascular vascular JJ cord-016990-ot1wi3xi 778 10 regulation regulation NN cord-016990-ot1wi3xi 778 11 and and CC cord-016990-ot1wi3xi 778 12 vascular vascular JJ cord-016990-ot1wi3xi 778 13 damage damage NN cord-016990-ot1wi3xi 778 14 and and CC cord-016990-ot1wi3xi 778 15 are be VBP cord-016990-ot1wi3xi 778 16 caused cause VBN cord-016990-ot1wi3xi 778 17 by by IN cord-016990-ot1wi3xi 778 18 small small JJ cord-016990-ot1wi3xi 778 19 , , , cord-016990-ot1wi3xi 778 20 lipid lipid NN cord-016990-ot1wi3xi 778 21 - - HYPH cord-016990-ot1wi3xi 778 22 enveloped envelop VBN cord-016990-ot1wi3xi 778 23 RNA RNA NNP cord-016990-ot1wi3xi 778 24 viruses virus NNS cord-016990-ot1wi3xi 778 25 . . . cord-016990-ot1wi3xi 779 1 This this DT cord-016990-ot1wi3xi 779 2 syndrome syndrome NN cord-016990-ot1wi3xi 779 3 can can MD cord-016990-ot1wi3xi 779 4 be be VB cord-016990-ot1wi3xi 779 5 caused cause VBN cord-016990-ot1wi3xi 779 6 by by IN cord-016990-ot1wi3xi 779 7 viruses virus NNS cord-016990-ot1wi3xi 779 8 belonging belong VBG cord-016990-ot1wi3xi 779 9 to to IN cord-016990-ot1wi3xi 779 10 four four CD cord-016990-ot1wi3xi 779 11 different different JJ cord-016990-ot1wi3xi 779 12 families family NNS cord-016990-ot1wi3xi 779 13 that that WDT cord-016990-ot1wi3xi 779 14 differ differ VBP cord-016990-ot1wi3xi 779 15 in in IN cord-016990-ot1wi3xi 779 16 their -PRON- PRP$ cord-016990-ot1wi3xi 779 17 genomic genomic JJ cord-016990-ot1wi3xi 779 18 structure structure NN cord-016990-ot1wi3xi 779 19 , , , cord-016990-ot1wi3xi 779 20 replication replication NN cord-016990-ot1wi3xi 779 21 strategy strategy NN cord-016990-ot1wi3xi 779 22 , , , cord-016990-ot1wi3xi 779 23 and and CC cord-016990-ot1wi3xi 779 24 morphologic morphologic JJ cord-016990-ot1wi3xi 779 25 features feature NNS cord-016990-ot1wi3xi 779 26 ( ( -LRB- cord-016990-ot1wi3xi 779 27 Table table NN cord-016990-ot1wi3xi 779 28 11 11 CD cord-016990-ot1wi3xi 779 29 .4 .4 CD cord-016990-ot1wi3xi 779 30 ) ) -RRB- cord-016990-ot1wi3xi 779 31 . . . cord-016990-ot1wi3xi 780 1 Arenaviruses Arenaviruses NNP cord-016990-ot1wi3xi 780 2 , , , cord-016990-ot1wi3xi 780 3 bunyaviruses bunyavirus NNS cord-016990-ot1wi3xi 780 4 , , , cord-016990-ot1wi3xi 780 5 and and CC cord-016990-ot1wi3xi 780 6 filoviruses filovirus NNS cord-016990-ot1wi3xi 780 7 are be VBP cord-016990-ot1wi3xi 780 8 negative negative JJ cord-016990-ot1wi3xi 780 9 - - HYPH cord-016990-ot1wi3xi 780 10 stranded stranded JJ cord-016990-ot1wi3xi 780 11 , , , cord-016990-ot1wi3xi 780 12 459 459 CD cord-016990-ot1wi3xi 780 13 in in IN cord-016990-ot1wi3xi 780 14 the the DT cord-016990-ot1wi3xi 780 15 nucleus nucleus NN cord-016990-ot1wi3xi 780 16 and and CC cord-016990-ot1wi3xi 780 17 cytoplasm cytoplasm NN cord-016990-ot1wi3xi 780 18 of of IN cord-016990-ot1wi3xi 780 19 erythroid erythroid JJ cord-016990-ot1wi3xi 780 20 precursors precursor NNS cord-016990-ot1wi3xi 780 21 by by IN cord-016990-ot1wi3xi 780 22 using use VBG cord-016990-ot1wi3xi 780 23 immunohistochemistry immunohistochemistry NN cord-016990-ot1wi3xi 780 24 ( ( -LRB- cord-016990-ot1wi3xi 780 25 IHe ihe NN cord-016990-ot1wi3xi 780 26 ) ) -RRB- cord-016990-ot1wi3xi 780 27 ( ( -LRB- cord-016990-ot1wi3xi 780 28 same same JJ cord-016990-ot1wi3xi 780 29 patient patient NN cord-016990-ot1wi3xi 780 30 as as IN cord-016990-ot1wi3xi 780 31 in in IN cord-016990-ot1wi3xi 780 32 A A NNP cord-016990-ot1wi3xi 780 33 , , , cord-016990-ot1wi3xi 780 34 B b NN cord-016990-ot1wi3xi 780 35 ) ) -RRB- cord-016990-ot1wi3xi 780 36 . . . cord-016990-ot1wi3xi 781 1 A a LS cord-016990-ot1wi3xi 781 2 , , , cord-016990-ot1wi3xi 781 3 B b NN cord-016990-ot1wi3xi 781 4 , , , cord-016990-ot1wi3xi 781 5 H&E H&E NNP cord-016990-ot1wi3xi 781 6 ; ; : cord-016990-ot1wi3xi 781 7 C C NNP cord-016990-ot1wi3xi 781 8 , , , cord-016990-ot1wi3xi 781 9 D D NNP cord-016990-ot1wi3xi 781 10 , , , cord-016990-ot1wi3xi 781 11 immunoalkaline immunoalkaline JJ cord-016990-ot1wi3xi 781 12 phosphatase phosphatase NN cord-016990-ot1wi3xi 781 13 staining staining NN cord-016990-ot1wi3xi 781 14 , , , cord-016990-ot1wi3xi 781 15 naphthol naphthol NNP cord-016990-ot1wi3xi 781 16 fast fast JJ cord-016990-ot1wi3xi 781 17 - - HYPH cord-016990-ot1wi3xi 781 18 red red NN cord-016990-ot1wi3xi 781 19 , , , cord-016990-ot1wi3xi 781 20 and and CC cord-016990-ot1wi3xi 781 21 hematoxylin hematoxylin NNP cord-016990-ot1wi3xi 781 22 counterstain counterstain NNP cord-016990-ot1wi3xi 781 23 . . . cord-016990-ot1wi3xi 782 1 whereas whereas IN cord-016990-ot1wi3xi 782 2 fiaviviruses fiaviviruses NNP cord-016990-ot1wi3xi 782 3 are be VBP cord-016990-ot1wi3xi 782 4 positive positive JJ cord-016990-ot1wi3xi 782 5 - - HYPH cord-016990-ot1wi3xi 782 6 stranded strand VBN cord-016990-ot1wi3xi 782 7 RNA RNA NNP cord-016990-ot1wi3xi 782 8 viruses virus NNS cord-016990-ot1wi3xi 782 9 . . . cord-016990-ot1wi3xi 783 1 Hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 783 2 fever fever NN cord-016990-ot1wi3xi 783 3 viruses virus NNS cord-016990-ot1wi3xi 783 4 are be VBP cord-016990-ot1wi3xi 783 5 distributed distribute VBN cord-016990-ot1wi3xi 783 6 worldwide worldwide RB cord-016990-ot1wi3xi 783 7 , , , cord-016990-ot1wi3xi 783 8 and and CC cord-016990-ot1wi3xi 783 9 the the DT cord-016990-ot1wi3xi 783 10 diseases disease NNS cord-016990-ot1wi3xi 783 11 they -PRON- PRP cord-016990-ot1wi3xi 783 12 cause cause VBP cord-016990-ot1wi3xi 783 13 are be VBP cord-016990-ot1wi3xi 783 14 traditionally traditionally RB cord-016990-ot1wi3xi 783 15 named name VBN cord-016990-ot1wi3xi 783 16 according accord VBG cord-016990-ot1wi3xi 783 17 to to IN cord-016990-ot1wi3xi 783 18 the the DT cord-016990-ot1wi3xi 783 19 location location NN cord-016990-ot1wi3xi 783 20 where where WRB cord-016990-ot1wi3xi 783 21 they -PRON- PRP cord-016990-ot1wi3xi 783 22 were be VBD cord-016990-ot1wi3xi 783 23 first first RB cord-016990-ot1wi3xi 783 24 described describe VBN cord-016990-ot1wi3xi 783 25 . . . cord-016990-ot1wi3xi 784 1 The the DT cord-016990-ot1wi3xi 784 2 oldest old JJS cord-016990-ot1wi3xi 784 3 and and CC cord-016990-ot1wi3xi 784 4 best well RBS cord-016990-ot1wi3xi 784 5 known know VBN cord-016990-ot1wi3xi 784 6 is be VBZ cord-016990-ot1wi3xi 784 7 yellow yellow JJ cord-016990-ot1wi3xi 784 8 fever fever NN cord-016990-ot1wi3xi 784 9 virus virus NN cord-016990-ot1wi3xi 784 10 ; ; : cord-016990-ot1wi3xi 784 11 others other NNS cord-016990-ot1wi3xi 784 12 include include VBP cord-016990-ot1wi3xi 784 13 Lassa Lassa NNP cord-016990-ot1wi3xi 784 14 fever fever NN cord-016990-ot1wi3xi 784 15 , , , cord-016990-ot1wi3xi 784 16 lymphocytic lymphocytic JJ cord-016990-ot1wi3xi 784 17 choriomeningitis choriomeningitis NNP cord-016990-ot1wi3xi 784 18 , , , cord-016990-ot1wi3xi 784 19 Ebola Ebola NNP cord-016990-ot1wi3xi 784 20 , , , cord-016990-ot1wi3xi 784 21 and and CC cord-016990-ot1wi3xi 784 22 Dengue dengue NN cord-016990-ot1wi3xi 784 23 viruses virus NNS cord-016990-ot1wi3xi 784 24 . . . cord-016990-ot1wi3xi 785 1 Viral viral JJ cord-016990-ot1wi3xi 785 2 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 785 3 fevers fever NNS cord-016990-ot1wi3xi 785 4 share share VBP cord-016990-ot1wi3xi 785 5 many many JJ cord-016990-ot1wi3xi 785 6 common common JJ cord-016990-ot1wi3xi 785 7 pathologic pathologic JJ cord-016990-ot1wi3xi 785 8 features feature NNS cord-016990-ot1wi3xi 785 9 , , , cord-016990-ot1wi3xi 785 10 although although IN cord-016990-ot1wi3xi 785 11 the the DT cord-016990-ot1wi3xi 785 12 overall overall JJ cord-016990-ot1wi3xi 785 13 changes change NNS cord-016990-ot1wi3xi 785 14 vary vary VBP cord-016990-ot1wi3xi 785 15 among among IN cord-016990-ot1wi3xi 785 16 the the DT cord-016990-ot1wi3xi 785 17 different different JJ cord-016990-ot1wi3xi 785 18 diseases disease NNS cord-016990-ot1wi3xi 785 19 . . . cord-016990-ot1wi3xi 786 1 The the DT cord-016990-ot1wi3xi 786 2 similar similar JJ cord-016990-ot1wi3xi 786 3 pathologic pathologic JJ cord-016990-ot1wi3xi 786 4 and and CC cord-016990-ot1wi3xi 786 5 immunopathologic immunopathologic JJ cord-016990-ot1wi3xi 786 6 findings finding NNS cord-016990-ot1wi3xi 786 7 in in IN cord-016990-ot1wi3xi 786 8 cases case NNS cord-016990-ot1wi3xi 786 9 of of IN cord-016990-ot1wi3xi 786 10 VHF VHF NNP cord-016990-ot1wi3xi 786 11 suggest suggest VBP cord-016990-ot1wi3xi 786 12 that that IN cord-016990-ot1wi3xi 786 13 microvascular microvascular JJ cord-016990-ot1wi3xi 786 14 involvement involvement NN cord-016990-ot1wi3xi 786 15 and and CC cord-016990-ot1wi3xi 786 16 instability instability NN cord-016990-ot1wi3xi 786 17 is be VBZ cord-016990-ot1wi3xi 786 18 an an DT cord-016990-ot1wi3xi 786 19 important important JJ cord-016990-ot1wi3xi 786 20 common common JJ cord-016990-ot1wi3xi 786 21 pathogenic pathogenic JJ cord-016990-ot1wi3xi 786 22 pathway pathway NN cord-016990-ot1wi3xi 786 23 leading lead VBG cord-016990-ot1wi3xi 786 24 to to IN cord-016990-ot1wi3xi 786 25 shock shock NN cord-016990-ot1wi3xi 786 26 and and CC cord-016990-ot1wi3xi 786 27 bleeding bleed VBG cord-016990-ot1wi3xi 786 28 in in IN cord-016990-ot1wi3xi 786 29 many many JJ cord-016990-ot1wi3xi 786 30 instances instance NNS cord-016990-ot1wi3xi 786 31 . . . cord-016990-ot1wi3xi 787 1 Infection infection NN cord-016990-ot1wi3xi 787 2 of of IN cord-016990-ot1wi3xi 787 3 the the DT cord-016990-ot1wi3xi 787 4 mononuclear mononuclear JJ cord-016990-ot1wi3xi 787 5 phagocytic phagocytic JJ cord-016990-ot1wi3xi 787 6 system system NN cord-016990-ot1wi3xi 787 7 and and CC cord-016990-ot1wi3xi 787 8 endothelium endothelium NN cord-016990-ot1wi3xi 787 9 are be VBP cord-016990-ot1wi3xi 787 10 thought think VBN cord-016990-ot1wi3xi 787 11 to to TO cord-016990-ot1wi3xi 787 12 play play VB cord-016990-ot1wi3xi 787 13 c c NNP cord-016990-ot1wi3xi 787 14 S.R. S.R. NNP cord-016990-ot1wi3xi 787 15 Zaki Zaki NNP cord-016990-ot1wi3xi 787 16 and and CC cord-016990-ot1wi3xi 787 17 CD CD NNP cord-016990-ot1wi3xi 787 18 . . . cord-016990-ot1wi3xi 788 1 Paddock paddock NN cord-016990-ot1wi3xi 788 2 11 11 CD cord-016990-ot1wi3xi 788 3 .17 .17 CD cord-016990-ot1wi3xi 788 4 . . . cord-016990-ot1wi3xi 789 1 Ebola Ebola NNP cord-016990-ot1wi3xi 789 2 virus virus NN cord-016990-ot1wi3xi 789 3 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 789 4 fever fever NN cord-016990-ot1wi3xi 789 5 . . . cord-016990-ot1wi3xi 790 1 A. a. JJ cord-016990-ot1wi3xi 790 2 Pulmonary pulmonary JJ cord-016990-ot1wi3xi 790 3 congestion congestion NN cord-016990-ot1wi3xi 790 4 and and CC cord-016990-ot1wi3xi 790 5 lack lack NN cord-016990-ot1wi3xi 790 6 of of IN cord-016990-ot1wi3xi 790 7 inflammation inflammation NN cord-016990-ot1wi3xi 790 8 . . . cord-016990-ot1wi3xi 791 1 B. B. NNP cord-016990-ot1wi3xi 792 1 Numerous numerous JJ cord-016990-ot1wi3xi 792 2 filamentous filamentous JJ cord-016990-ot1wi3xi 792 3 Ebola Ebola NNP cord-016990-ot1wi3xi 792 4 virus virus NN cord-016990-ot1wi3xi 792 5 inclusions inclusion NNS cord-016990-ot1wi3xi 792 6 are be VBP cord-016990-ot1wi3xi 792 7 seen see VBN cord-016990-ot1wi3xi 792 8 within within IN cord-016990-ot1wi3xi 792 9 hepatocytes hepatocyte NNS cord-016990-ot1wi3xi 792 10 in in IN cord-016990-ot1wi3xi 792 11 association association NN cord-016990-ot1wi3xi 792 12 with with IN cord-016990-ot1wi3xi 792 13 hepatocellular hepatocellular JJ cord-016990-ot1wi3xi 792 14 necrosis necrosis NN cord-016990-ot1wi3xi 792 15 . . . cord-016990-ot1wi3xi 793 1 C. C. NNP cord-016990-ot1wi3xi 793 2 Ebola Ebola NNP cord-016990-ot1wi3xi 793 3 virus virus NN cord-016990-ot1wi3xi 793 4 - - HYPH cord-016990-ot1wi3xi 793 5 infected infect VBN cord-016990-ot1wi3xi 793 6 intra intra JJ cord-016990-ot1wi3xi 793 7 alveolar alveolar NN cord-016990-ot1wi3xi 793 8 macrophages macrophage NNS cord-016990-ot1wi3xi 793 9 as as IN cord-016990-ot1wi3xi 793 10 seen see VBN cord-016990-ot1wi3xi 793 11 by by IN cord-016990-ot1wi3xi 793 12 colorimetric colorimetric JJ cord-016990-ot1wi3xi 793 13 in in NN cord-016990-ot1wi3xi 793 14 - - HYPH cord-016990-ot1wi3xi 793 15 situ situ NN cord-016990-ot1wi3xi 793 16 hybridization hybridization NN cord-016990-ot1wi3xi 793 17 using use VBG cord-016990-ot1wi3xi 793 18 digoxigenin digoxigenin NNP cord-016990-ot1wi3xi 793 19 - - HYPH cord-016990-ot1wi3xi 793 20 labeled label VBN cord-016990-ot1wi3xi 793 21 probes probe NNS cord-016990-ot1wi3xi 793 22 . . . cord-016990-ot1wi3xi 794 1 D. D. NNP cord-016990-ot1wi3xi 794 2 Viral Viral NNP cord-016990-ot1wi3xi 794 3 anti anti JJ cord-016990-ot1wi3xi 794 4 - - NNS cord-016990-ot1wi3xi 794 5 gens gen NNS cord-016990-ot1wi3xi 794 6 are be VBP cord-016990-ot1wi3xi 794 7 seen see VBN cord-016990-ot1wi3xi 794 8 in in IN cord-016990-ot1wi3xi 794 9 endothelial endothelial JJ cord-016990-ot1wi3xi 794 10 cells cell NNS cord-016990-ot1wi3xi 794 11 and and CC cord-016990-ot1wi3xi 794 12 other other JJ cord-016990-ot1wi3xi 794 13 interstitial interstitial JJ cord-016990-ot1wi3xi 794 14 cells cell NNS cord-016990-ot1wi3xi 794 15 in in IN cord-016990-ot1wi3xi 794 16 this this DT cord-016990-ot1wi3xi 794 17 lung lung NN cord-016990-ot1wi3xi 794 18 section section NN cord-016990-ot1wi3xi 794 19 . . . cord-016990-ot1wi3xi 795 1 A a LS cord-016990-ot1wi3xi 795 2 , , , cord-016990-ot1wi3xi 795 3 B b NN cord-016990-ot1wi3xi 795 4 , , , cord-016990-ot1wi3xi 795 5 H&E H&E NNP cord-016990-ot1wi3xi 795 6 ; ; : cord-016990-ot1wi3xi 795 7 C C NNP cord-016990-ot1wi3xi 795 8 , , , cord-016990-ot1wi3xi 795 9 digoxigenin digoxigenin NNP cord-016990-ot1wi3xi 795 10 - - HYPH cord-016990-ot1wi3xi 795 11 labeled label VBN cord-016990-ot1wi3xi 795 12 probes probe NNS cord-016990-ot1wi3xi 795 13 followed follow VBN cord-016990-ot1wi3xi 795 14 by by IN cord-016990-ot1wi3xi 795 15 immunoalkaline immunoalkaline JJ cord-016990-ot1wi3xi 795 16 phosphatase phosphatase NN cord-016990-ot1wi3xi 795 17 staining staining NN cord-016990-ot1wi3xi 795 18 , , , cord-016990-ot1wi3xi 795 19 naphthol naphthol NNP cord-016990-ot1wi3xi 795 20 fast fast JJ cord-016990-ot1wi3xi 795 21 - - HYPH cord-016990-ot1wi3xi 795 22 red red NN cord-016990-ot1wi3xi 795 23 , , , cord-016990-ot1wi3xi 795 24 and and CC cord-016990-ot1wi3xi 795 25 hematoxylin hematoxylin NNP cord-016990-ot1wi3xi 795 26 counterstain counterstain NNP cord-016990-ot1wi3xi 795 27 ; ; : cord-016990-ot1wi3xi 795 28 D D NNP cord-016990-ot1wi3xi 795 29 , , , cord-016990-ot1wi3xi 795 30 immunoalkaline immunoalkaline JJ cord-016990-ot1wi3xi 795 31 phosphatase phosphatase NN cord-016990-ot1wi3xi 795 32 staining staining NN cord-016990-ot1wi3xi 795 33 , , , cord-016990-ot1wi3xi 795 34 naphthol naphthol NNP cord-016990-ot1wi3xi 795 35 fast fast JJ cord-016990-ot1wi3xi 795 36 - - HYPH cord-016990-ot1wi3xi 795 37 red red NN cord-016990-ot1wi3xi 795 38 , , , cord-016990-ot1wi3xi 795 39 and and CC cord-016990-ot1wi3xi 795 40 hematoxylin hematoxylin NNP cord-016990-ot1wi3xi 795 41 counterstain counterstain NNP cord-016990-ot1wi3xi 795 42 . . . cord-016990-ot1wi3xi 796 1 FIGURE figure NN cord-016990-ot1wi3xi 796 2 11.18 11.18 CD cord-016990-ot1wi3xi 796 3 . . . cord-016990-ot1wi3xi 797 1 Yellow yellow JJ cord-016990-ot1wi3xi 797 2 fever fever NN cord-016990-ot1wi3xi 797 3 . . . cord-016990-ot1wi3xi 798 1 A. a. JJ cord-016990-ot1wi3xi 798 2 Pulmonary pulmonary JJ cord-016990-ot1wi3xi 798 3 congestion congestion NN cord-016990-ot1wi3xi 798 4 in in IN cord-016990-ot1wi3xi 798 5 fatal fatal JJ cord-016990-ot1wi3xi 798 6 case case NN cord-016990-ot1wi3xi 798 7 of of IN cord-016990-ot1wi3xi 798 8 yellow yellow JJ cord-016990-ot1wi3xi 798 9 fever fever NN cord-016990-ot1wi3xi 798 10 associated associate VBN cord-016990-ot1wi3xi 798 11 with with IN cord-016990-ot1wi3xi 798 12 vaccination vaccination NN cord-016990-ot1wi3xi 798 13 . . . cord-016990-ot1wi3xi 799 1 B. B. NNP cord-016990-ot1wi3xi 799 2 Yellow Yellow NNP cord-016990-ot1wi3xi 799 3 fever fever NN cord-016990-ot1wi3xi 799 4 antigens antigen NNS cord-016990-ot1wi3xi 799 5 in in IN cord-016990-ot1wi3xi 799 6 the the DT cord-016990-ot1wi3xi 799 7 pulmonary pulmonary JJ cord-016990-ot1wi3xi 799 8 interstitium interstitium NN cord-016990-ot1wi3xi 799 9 of of IN cord-016990-ot1wi3xi 799 10 the the DT cord-016990-ot1wi3xi 799 11 same same JJ cord-016990-ot1wi3xi 799 12 patient patient NN cord-016990-ot1wi3xi 799 13 . . . cord-016990-ot1wi3xi 800 1 In in IN cord-016990-ot1wi3xi 800 2 natural natural JJ cord-016990-ot1wi3xi 800 3 infections infection NNS cord-016990-ot1wi3xi 800 4 , , , cord-016990-ot1wi3xi 800 5 yellow yellow JJ cord-016990-ot1wi3xi 800 6 fever fever NN cord-016990-ot1wi3xi 800 7 antigens antigen NNS cord-016990-ot1wi3xi 800 8 are be VBP cord-016990-ot1wi3xi 800 9 usually usually RB cord-016990-ot1wi3xi 800 10 not not RB cord-016990-ot1wi3xi 800 11 seen see VBN cord-016990-ot1wi3xi 800 12 outside outside IN cord-016990-ot1wi3xi 800 13 the the DT cord-016990-ot1wi3xi 800 14 liver liver NN cord-016990-ot1wi3xi 800 15 in in IN cord-016990-ot1wi3xi 800 16 fatal fatal JJ cord-016990-ot1wi3xi 800 17 cases case NNS cord-016990-ot1wi3xi 800 18 . . . cord-016990-ot1wi3xi 801 1 In in IN cord-016990-ot1wi3xi 801 2 contrast contrast NN cord-016990-ot1wi3xi 801 3 , , , cord-016990-ot1wi3xi 801 4 in in IN cord-016990-ot1wi3xi 801 5 vaccine vaccine NN cord-016990-ot1wi3xi 801 6 - - HYPH cord-016990-ot1wi3xi 801 7 associated associate VBN cord-016990-ot1wi3xi 801 8 cases case NNS cord-016990-ot1wi3xi 801 9 viral viral JJ cord-016990-ot1wi3xi 801 10 antigens antigen NNS cord-016990-ot1wi3xi 801 11 can can MD cord-016990-ot1wi3xi 801 12 be be VB cord-016990-ot1wi3xi 801 13 found find VBN cord-016990-ot1wi3xi 801 14 in in IN cord-016990-ot1wi3xi 801 15 a a DT cord-016990-ot1wi3xi 801 16 variety variety NN cord-016990-ot1wi3xi 801 17 of of IN cord-016990-ot1wi3xi 801 18 extrapulmonary extrapulmonary NNP cord-016990-ot1wi3xi 801 19 a a DT cord-016990-ot1wi3xi 801 20 critical critical JJ cord-016990-ot1wi3xi 801 21 role role NN cord-016990-ot1wi3xi 801 22 in in IN cord-016990-ot1wi3xi 801 23 the the DT cord-016990-ot1wi3xi 801 24 pathogenesis pathogenesis NN cord-016990-ot1wi3xi 801 25 of of IN cord-016990-ot1wi3xi 801 26 VHFs vhf NNS cord-016990-ot1wi3xi 801 27 through through IN cord-016990-ot1wi3xi 801 28 the the DT cord-016990-ot1wi3xi 801 29 secretion secretion NN cord-016990-ot1wi3xi 801 30 of of IN cord-016990-ot1wi3xi 801 31 physiologically physiologically RB cord-016990-ot1wi3xi 801 32 active active JJ cord-016990-ot1wi3xi 801 33 substances substance NNS cord-016990-ot1wi3xi 801 34 , , , cord-016990-ot1wi3xi 801 35 including include VBG cord-016990-ot1wi3xi 801 36 cytokines cytokine NNS cord-016990-ot1wi3xi 801 37 and and CC cord-016990-ot1wi3xi 801 38 other other JJ cord-016990-ot1wi3xi 801 39 inflammatory inflammatory JJ cord-016990-ot1wi3xi 801 40 mediators mediator NNS cord-016990-ot1wi3xi 801 41 ( ( -LRB- cord-016990-ot1wi3xi 801 42 Figs fig NNS cord-016990-ot1wi3xi 801 43 . . . cord-016990-ot1wi3xi 802 1 11.17C 11.17c CD cord-016990-ot1wi3xi 802 2 , , , cord-016990-ot1wi3xi 802 3 D D NNP cord-016990-ot1wi3xi 802 4 , , , cord-016990-ot1wi3xi 802 5 11.18B 11.18b CD cord-016990-ot1wi3xi 802 6 , , , cord-016990-ot1wi3xi 802 7 11.19B 11.19b CD cord-016990-ot1wi3xi 802 8 , , , cord-016990-ot1wi3xi 802 9 C C NNP cord-016990-ot1wi3xi 802 10 , , , cord-016990-ot1wi3xi 802 11 and and CC cord-016990-ot1wi3xi 802 12 11.20B 11.20b CD cord-016990-ot1wi3xi 802 13 ) ) -RRB- cord-016990-ot1wi3xi 802 14 . . . cord-016990-ot1wi3xi 803 1 At at IN cord-016990-ot1wi3xi 803 2 autopsy autopsy JJ cord-016990-ot1wi3xi 803 3 common common JJ cord-016990-ot1wi3xi 803 4 findings finding NNS cord-016990-ot1wi3xi 803 5 include include VBP cord-016990-ot1wi3xi 803 6 widespread widespread JJ cord-016990-ot1wi3xi 803 7 petechial petechial JJ cord-016990-ot1wi3xi 803 8 hemorrhages hemorrhage NNS cord-016990-ot1wi3xi 803 9 and and CC cord-016990-ot1wi3xi 803 10 ecchymoses ecchymosis NNS cord-016990-ot1wi3xi 803 11 involving involve VBG cord-016990-ot1wi3xi 803 12 skin skin NN cord-016990-ot1wi3xi 803 13 , , , cord-016990-ot1wi3xi 803 14 mucous mucous JJ cord-016990-ot1wi3xi 803 15 membranes membrane NNS cord-016990-ot1wi3xi 803 16 , , , cord-016990-ot1wi3xi 803 17 and and CC cord-016990-ot1wi3xi 803 18 internal internal JJ cord-016990-ot1wi3xi 803 19 organs organ NNS cord-016990-ot1wi3xi 803 20 . . . cord-016990-ot1wi3xi 804 1 However however RB cord-016990-ot1wi3xi 804 2 , , , cord-016990-ot1wi3xi 804 3 in in IN cord-016990-ot1wi3xi 804 4 many many JJ cord-016990-ot1wi3xi 804 5 HF HF NNP cord-016990-ot1wi3xi 804 6 patients patient NNS cord-016990-ot1wi3xi 804 7 manifestations manifestation NNS cord-016990-ot1wi3xi 804 8 of of IN cord-016990-ot1wi3xi 804 9 bleeding bleed VBG cord-016990-ot1wi3xi 804 10 may may MD cord-016990-ot1wi3xi 804 11 be be VB cord-016990-ot1wi3xi 804 12 minimal minimal JJ cord-016990-ot1wi3xi 804 13 or or CC cord-016990-ot1wi3xi 804 14 absent absent JJ cord-016990-ot1wi3xi 804 15 . . . cord-016990-ot1wi3xi 805 1 Effusions effusion NNS cord-016990-ot1wi3xi 805 2 , , , cord-016990-ot1wi3xi 805 3 occasionally occasionally RB cord-016990-ot1wi3xi 805 4 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 805 5 , , , cord-016990-ot1wi3xi 805 6 are be VBP cord-016990-ot1wi3xi 805 7 also also RB cord-016990-ot1wi3xi 805 8 frequently frequently RB cord-016990-ot1wi3xi 805 9 seen see VBN cord-016990-ot1wi3xi 805 10 . . . cord-016990-ot1wi3xi 806 1 Widespread widespread JJ cord-016990-ot1wi3xi 806 2 , , , cord-016990-ot1wi3xi 806 3 focal focal JJ cord-016990-ot1wi3xi 806 4 , , , cord-016990-ot1wi3xi 806 5 and and CC cord-016990-ot1wi3xi 806 6 sometimes sometimes RB cord-016990-ot1wi3xi 807 1 massive massive JJ cord-016990-ot1wi3xi 807 2 necrosis necrosis NN cord-016990-ot1wi3xi 807 3 can can MD cord-016990-ot1wi3xi 807 4 be be VB cord-016990-ot1wi3xi 807 5 commonly commonly RB cord-016990-ot1wi3xi 807 6 observed observe VBN cord-016990-ot1wi3xi 807 7 in in IN cord-016990-ot1wi3xi 807 8 all all DT cord-016990-ot1wi3xi 807 9 organ organ NN cord-016990-ot1wi3xi 807 10 systems system NNS cord-016990-ot1wi3xi 807 11 and and CC cord-016990-ot1wi3xi 807 12 is be VBZ cord-016990-ot1wi3xi 807 13 often often RB cord-016990-ot1wi3xi 807 14 ischemic ischemic JJ cord-016990-ot1wi3xi 807 15 in in IN cord-016990-ot1wi3xi 807 16 nature nature NN cord-016990-ot1wi3xi 807 17 . . . cord-016990-ot1wi3xi 808 1 Necrosis necrosis NN cord-016990-ot1wi3xi 808 2 is be VBZ cord-016990-ot1wi3xi 808 3 usually usually RB cord-016990-ot1wi3xi 808 4 most most RBS cord-016990-ot1wi3xi 808 5 prominent prominent JJ cord-016990-ot1wi3xi 808 6 in in IN cord-016990-ot1wi3xi 808 7 the the DT cord-016990-ot1wi3xi 808 8 liver liver NN cord-016990-ot1wi3xi 808 9 and and CC cord-016990-ot1wi3xi 808 10 lymphoid lymphoid JJ cord-016990-ot1wi3xi 808 11 tissues tissue NNS cord-016990-ot1wi3xi 808 12 . . . cord-016990-ot1wi3xi 809 1 The the DT cord-016990-ot1wi3xi 809 2 most most JJS cord-016990-ot1wi3xi 809 3 con-461 con-461 JJ cord-016990-ot1wi3xi 809 4 organs organ NNS cord-016990-ot1wi3xi 809 5 , , , cord-016990-ot1wi3xi 809 6 including include VBG cord-016990-ot1wi3xi 809 7 heart heart NN cord-016990-ot1wi3xi 809 8 , , , cord-016990-ot1wi3xi 809 9 lung lung NN cord-016990-ot1wi3xi 809 10 , , , cord-016990-ot1wi3xi 809 11 and and CC cord-016990-ot1wi3xi 809 12 spleen spleen NNS cord-016990-ot1wi3xi 809 13 . . . cord-016990-ot1wi3xi 810 1 C. C. NNP cord-016990-ot1wi3xi 811 1 Extensive extensive JJ cord-016990-ot1wi3xi 811 2 midzonal midzonal JJ cord-016990-ot1wi3xi 811 3 hepatic hepatic JJ cord-016990-ot1wi3xi 811 4 necrosis necrosis NN cord-016990-ot1wi3xi 811 5 characteristic characteristic NN cord-016990-ot1wi3xi 811 6 of of IN cord-016990-ot1wi3xi 811 7 yellow yellow JJ cord-016990-ot1wi3xi 811 8 fever fever NN cord-016990-ot1wi3xi 811 9 . . . cord-016990-ot1wi3xi 812 1 D. D. NNP cord-016990-ot1wi3xi 813 1 Abundant abundant JJ cord-016990-ot1wi3xi 813 2 antigens antigen NNS cord-016990-ot1wi3xi 813 3 of of IN cord-016990-ot1wi3xi 813 4 yellow yellow JJ cord-016990-ot1wi3xi 813 5 fever fever NN cord-016990-ot1wi3xi 813 6 virus virus NN cord-016990-ot1wi3xi 813 7 are be VBP cord-016990-ot1wi3xi 813 8 observed observe VBN cord-016990-ot1wi3xi 813 9 in in IN cord-016990-ot1wi3xi 813 10 midzonal midzonal JJ cord-016990-ot1wi3xi 813 11 area area NN cord-016990-ot1wi3xi 813 12 of of IN cord-016990-ot1wi3xi 813 13 hepatic hepatic JJ cord-016990-ot1wi3xi 813 14 lobule lobule NN cord-016990-ot1wi3xi 813 15 in in IN cord-016990-ot1wi3xi 813 16 this this DT cord-016990-ot1wi3xi 813 17 immunohistochemical immunohistochemical JJ cord-016990-ot1wi3xi 813 18 preparation preparation NN cord-016990-ot1wi3xi 813 19 . . . cord-016990-ot1wi3xi 814 1 A A NNP cord-016990-ot1wi3xi 814 2 , , , cord-016990-ot1wi3xi 814 3 C C NNP cord-016990-ot1wi3xi 814 4 , , , cord-016990-ot1wi3xi 814 5 H&E H&E NNP cord-016990-ot1wi3xi 814 6 ; ; : cord-016990-ot1wi3xi 814 7 B b NN cord-016990-ot1wi3xi 814 8 , , , cord-016990-ot1wi3xi 814 9 D D NNP cord-016990-ot1wi3xi 814 10 , , , cord-016990-ot1wi3xi 814 11 immunoalkaline immunoalkaline JJ cord-016990-ot1wi3xi 814 12 phosphatase phosphatase NN cord-016990-ot1wi3xi 814 13 staining staining NN cord-016990-ot1wi3xi 814 14 , , , cord-016990-ot1wi3xi 814 15 naphthol naphthol NNP cord-016990-ot1wi3xi 814 16 fast fast JJ cord-016990-ot1wi3xi 814 17 - - HYPH cord-016990-ot1wi3xi 814 18 red red NN cord-016990-ot1wi3xi 814 19 , , , cord-016990-ot1wi3xi 814 20 and and CC cord-016990-ot1wi3xi 814 21 hematoxylin hematoxylin NNP cord-016990-ot1wi3xi 814 22 counterstain counterstain NNP cord-016990-ot1wi3xi 814 23 . . . cord-016990-ot1wi3xi 815 1 sistent sistent NNP cord-016990-ot1wi3xi 815 2 microscopic microscopic JJ cord-016990-ot1wi3xi 815 3 feature feature NN cord-016990-ot1wi3xi 815 4 is be VBZ cord-016990-ot1wi3xi 815 5 found find VBN cord-016990-ot1wi3xi 815 6 in in IN cord-016990-ot1wi3xi 815 7 the the DT cord-016990-ot1wi3xi 815 8 liver liver NN cord-016990-ot1wi3xi 815 9 and and CC cord-016990-ot1wi3xi 815 10 consists consist VBZ cord-016990-ot1wi3xi 815 11 of of IN cord-016990-ot1wi3xi 815 12 multifocal multifocal JJ cord-016990-ot1wi3xi 815 13 hepatocellular hepatocellular JJ cord-016990-ot1wi3xi 815 14 necrosis necrosis NN cord-016990-ot1wi3xi 815 15 with with IN cord-016990-ot1wi3xi 815 16 cytoplasmic cytoplasmic JJ cord-016990-ot1wi3xi 815 17 eosinophilia eosinophilia NN cord-016990-ot1wi3xi 815 18 , , , cord-016990-ot1wi3xi 815 19 Councilman councilman NN cord-016990-ot1wi3xi 815 20 bodies body NNS cord-016990-ot1wi3xi 815 21 , , , cord-016990-ot1wi3xi 815 22 nuclear nuclear JJ cord-016990-ot1wi3xi 815 23 pyknosis pyknosis NN cord-016990-ot1wi3xi 815 24 , , , cord-016990-ot1wi3xi 815 25 and and CC cord-016990-ot1wi3xi 815 26 cytolysis cytolysis NNP cord-016990-ot1wi3xi 815 27 ( ( -LRB- cord-016990-ot1wi3xi 815 28 Figs fig NNS cord-016990-ot1wi3xi 815 29 . . . cord-016990-ot1wi3xi 816 1 11.17B 11.17b CD cord-016990-ot1wi3xi 816 2 and and CC cord-016990-ot1wi3xi 816 3 11.18C 11.18c CD cord-016990-ot1wi3xi 816 4 ) ) -RRB- cord-016990-ot1wi3xi 816 5 . . . cord-016990-ot1wi3xi 817 1 Inflammatory inflammatory JJ cord-016990-ot1wi3xi 817 2 cell cell NN cord-016990-ot1wi3xi 817 3 infiltrates infiltrate VBZ cord-016990-ot1wi3xi 817 4 and and CC cord-016990-ot1wi3xi 817 5 necrotic necrotic JJ cord-016990-ot1wi3xi 817 6 areas area NNS cord-016990-ot1wi3xi 817 7 are be VBP cord-016990-ot1wi3xi 817 8 usually usually RB cord-016990-ot1wi3xi 817 9 mild mild JJ cord-016990-ot1wi3xi 817 10 and and CC cord-016990-ot1wi3xi 817 11 , , , cord-016990-ot1wi3xi 817 12 when when WRB cord-016990-ot1wi3xi 817 13 present present JJ cord-016990-ot1wi3xi 817 14 , , , cord-016990-ot1wi3xi 817 15 consist consist VBP cord-016990-ot1wi3xi 817 16 of of IN cord-016990-ot1wi3xi 817 17 neutrophils neutrophil NNS cord-016990-ot1wi3xi 817 18 and and CC cord-016990-ot1wi3xi 817 19 mononuclear mononuclear NN cord-016990-ot1wi3xi 817 20 cells cell NNS cord-016990-ot1wi3xi 817 21 . . . cord-016990-ot1wi3xi 818 1 Commonly commonly RB cord-016990-ot1wi3xi 818 2 observed observe VBN cord-016990-ot1wi3xi 818 3 histopathologic histopathologic JJ cord-016990-ot1wi3xi 818 4 changes change NNS cord-016990-ot1wi3xi 818 5 in in IN cord-016990-ot1wi3xi 818 6 the the DT cord-016990-ot1wi3xi 818 7 lung lung NN cord-016990-ot1wi3xi 818 8 include include VBP cord-016990-ot1wi3xi 818 9 various various JJ cord-016990-ot1wi3xi 818 10 degrees degree NNS cord-016990-ot1wi3xi 818 11 of of IN cord-016990-ot1wi3xi 818 12 hemorrhage hemorrhage NN cord-016990-ot1wi3xi 818 13 , , , cord-016990-ot1wi3xi 818 14 intra intra JJ cord-016990-ot1wi3xi 818 15 alveolar alveolar NN cord-016990-ot1wi3xi 818 16 edema edema NN cord-016990-ot1wi3xi 818 17 , , , cord-016990-ot1wi3xi 818 18 interstitial interstitial JJ cord-016990-ot1wi3xi 818 19 pneumonitis pneumonitis NN cord-016990-ot1wi3xi 818 20 , , , cord-016990-ot1wi3xi 818 21 and and CC cord-016990-ot1wi3xi 818 22 diffuse diffuse VB cord-016990-ot1wi3xi 818 23 alveolar alveolar NN cord-016990-ot1wi3xi 818 24 damage damage NN cord-016990-ot1wi3xi 819 1 ( ( -LRB- cord-016990-ot1wi3xi 819 2 Figs fig NNS cord-016990-ot1wi3xi 819 3 . . . cord-016990-ot1wi3xi 820 1 11.17 11.17 CD cord-016990-ot1wi3xi 820 2 A a DT cord-016990-ot1wi3xi 820 3 , , , cord-016990-ot1wi3xi 820 4 11.18A 11.18a CD cord-016990-ot1wi3xi 820 5 , , , cord-016990-ot1wi3xi 820 6 11.19A 11.19a CD cord-016990-ot1wi3xi 820 7 , , , cord-016990-ot1wi3xi 820 8 11.20A 11.20a CD cord-016990-ot1wi3xi 820 9 , , , cord-016990-ot1wi3xi 820 10 and and CC cord-016990-ot1wi3xi 820 11 11.21A 11.21a CD cord-016990-ot1wi3xi 820 12 ) ) -RRB- cord-016990-ot1wi3xi 820 13 . . . cord-016990-ot1wi3xi 821 1 Several several JJ cord-016990-ot1wi3xi 821 2 references reference NNS cord-016990-ot1wi3xi 821 3 containing contain VBG cord-016990-ot1wi3xi 821 4 detailed detailed JJ cord-016990-ot1wi3xi 821 5 pathologic pathologic JJ cord-016990-ot1wi3xi 821 6 descriptions description NNS cord-016990-ot1wi3xi 821 7 in in IN cord-016990-ot1wi3xi 821 8 human human JJ cord-016990-ot1wi3xi 821 9 cases case NNS cord-016990-ot1wi3xi 821 10 are be VBP cord-016990-ot1wi3xi 821 11 recommended recommend VBN cord-016990-ot1wi3xi 821 12 . . . cord-016990-ot1wi3xi 822 1 29.72.333 29.72.333 NNP cord-016990-ot1wi3xi 822 2 - - HYPH cord-016990-ot1wi3xi 822 3 35o 35o NNS cord-016990-ot1wi3xi 822 4 . . . cord-016990-ot1wi3xi 822 5 ' ' '' cord-016990-ot1wi3xi 823 1 A. a. JJ cord-016990-ot1wi3xi 823 2 Pulmonary pulmonary JJ cord-016990-ot1wi3xi 823 3 hemorrhage hemorrhage NN cord-016990-ot1wi3xi 823 4 and and CC cord-016990-ot1wi3xi 823 5 diffuse diffuse VB cord-016990-ot1wi3xi 823 6 alveolar alveolar JJ cord-016990-ot1wi3xi 823 7 damage damage NN cord-016990-ot1wi3xi 823 8 in in IN cord-016990-ot1wi3xi 823 9 a a DT cord-016990-ot1wi3xi 823 10 patient patient NN cord-016990-ot1wi3xi 823 11 who who WP cord-016990-ot1wi3xi 823 12 was be VBD cord-016990-ot1wi3xi 823 13 infected infect VBN cord-016990-ot1wi3xi 823 14 through through IN cord-016990-ot1wi3xi 823 15 organ organ NN cord-016990-ot1wi3xi 823 16 transplantation transplantation NN cord-016990-ot1wi3xi 823 17 . . . cord-016990-ot1wi3xi 824 1 Note note VB cord-016990-ot1wi3xi 824 2 that that IN cord-016990-ot1wi3xi 824 3 , , , cord-016990-ot1wi3xi 824 4 unlike unlike IN cord-016990-ot1wi3xi 824 5 this this DT cord-016990-ot1wi3xi 824 6 case case NN cord-016990-ot1wi3xi 824 7 , , , cord-016990-ot1wi3xi 824 8 which which WDT cord-016990-ot1wi3xi 824 9 occurred occur VBD cord-016990-ot1wi3xi 824 10 due due IN cord-016990-ot1wi3xi 824 11 to to IN cord-016990-ot1wi3xi 824 12 immunosuppression immunosuppression NN cord-016990-ot1wi3xi 824 13 , , , cord-016990-ot1wi3xi 824 14 LCMV LCMV NNP cord-016990-ot1wi3xi 824 15 infections infection NNS cord-016990-ot1wi3xi 824 16 are be VBP cord-016990-ot1wi3xi 824 17 rarely rarely RB cord-016990-ot1wi3xi 824 18 fatal fatal JJ cord-016990-ot1wi3xi 824 19 and and CC cord-016990-ot1wi3xi 824 20 usually usually RB cord-016990-ot1wi3xi 824 21 resolve resolve VB cord-016990-ot1wi3xi 824 22 with with IN cord-016990-ot1wi3xi 824 23 no no DT cord-016990-ot1wi3xi 824 24 specific specific JJ cord-016990-ot1wi3xi 824 25 treatment treatment NN cord-016990-ot1wi3xi 824 26 . . . cord-016990-ot1wi3xi 825 1 B. B. NNP cord-016990-ot1wi3xi 825 2 Abundant Abundant NNP cord-016990-ot1wi3xi 825 3 LCMV LCMV NNP cord-016990-ot1wi3xi 825 4 antigens antigen NNS cord-016990-ot1wi3xi 825 5 in in IN cord-016990-ot1wi3xi 825 6 areas area NNS cord-016990-ot1wi3xi 825 7 of of IN cord-016990-ot1wi3xi 825 8 The the DT cord-016990-ot1wi3xi 825 9 diagnosis diagnosis NN cord-016990-ot1wi3xi 825 10 of of IN cord-016990-ot1wi3xi 825 11 VHF VHF NNP cord-016990-ot1wi3xi 825 12 should should MD cord-016990-ot1wi3xi 825 13 be be VB cord-016990-ot1wi3xi 825 14 suspected suspect VBN cord-016990-ot1wi3xi 825 15 in in IN cord-016990-ot1wi3xi 825 16 patients patient NNS cord-016990-ot1wi3xi 825 17 with with IN cord-016990-ot1wi3xi 825 18 appropriate appropriate JJ cord-016990-ot1wi3xi 825 19 clinical clinical JJ cord-016990-ot1wi3xi 825 20 manifestations manifestation NNS cord-016990-ot1wi3xi 825 21 returning return VBG cord-016990-ot1wi3xi 825 22 from from IN cord-016990-ot1wi3xi 825 23 an an DT cord-016990-ot1wi3xi 825 24 endemic endemic JJ cord-016990-ot1wi3xi 825 25 area area NN cord-016990-ot1wi3xi 825 26 , , , cord-016990-ot1wi3xi 825 27 particularly particularly RB cord-016990-ot1wi3xi 825 28 if if IN cord-016990-ot1wi3xi 825 29 there there EX cord-016990-ot1wi3xi 825 30 is be VBZ cord-016990-ot1wi3xi 825 31 travel travel NN cord-016990-ot1wi3xi 825 32 to to IN cord-016990-ot1wi3xi 825 33 rural rural JJ cord-016990-ot1wi3xi 825 34 areas area NNS cord-016990-ot1wi3xi 825 35 during during IN cord-016990-ot1wi3xi 825 36 seasonal seasonal JJ cord-016990-ot1wi3xi 825 37 or or CC cord-016990-ot1wi3xi 825 38 epidemic epidemic JJ cord-016990-ot1wi3xi 825 39 disease disease NN cord-016990-ot1wi3xi 825 40 activity activity NN cord-016990-ot1wi3xi 825 41 . . . cord-016990-ot1wi3xi 826 1 The the DT cord-016990-ot1wi3xi 826 2 diagnosis diagnosis NN cord-016990-ot1wi3xi 826 3 suspected suspect VBN cord-016990-ot1wi3xi 826 4 by by IN cord-016990-ot1wi3xi 826 5 history history NN cord-016990-ot1wi3xi 826 6 and and CC cord-016990-ot1wi3xi 826 7 clinical clinical JJ cord-016990-ot1wi3xi 826 8 manifestations manifestation NNS cord-016990-ot1wi3xi 826 9 can can MD cord-016990-ot1wi3xi 826 10 also also RB cord-016990-ot1wi3xi 826 11 be be VB cord-016990-ot1wi3xi 826 12 supported support VBN cord-016990-ot1wi3xi 826 13 histopathologically histopathologically RB cord-016990-ot1wi3xi 826 14 , , , cord-016990-ot1wi3xi 826 15 and and CC cord-016990-ot1wi3xi 826 16 the the DT cord-016990-ot1wi3xi 826 17 overall overall JJ cord-016990-ot1wi3xi 826 18 pattern pattern NN cord-016990-ot1wi3xi 826 19 of of IN cord-016990-ot1wi3xi 826 20 histopathologic histopathologic JJ cord-016990-ot1wi3xi 826 21 lesions lesion NNS cord-016990-ot1wi3xi 826 22 may may MD cord-016990-ot1wi3xi 826 23 suggest suggest VB cord-016990-ot1wi3xi 826 24 a a DT cord-016990-ot1wi3xi 826 25 specific specific JJ cord-016990-ot1wi3xi 826 26 diagnosis diagnosis NN cord-016990-ot1wi3xi 826 27 . . . cord-016990-ot1wi3xi 827 1 However however RB cord-016990-ot1wi3xi 827 2 , , , cord-016990-ot1wi3xi 827 3 because because IN cord-016990-ot1wi3xi 827 4 of of IN cord-016990-ot1wi3xi 827 5 similar similar JJ cord-016990-ot1wi3xi 827 6 pathologic pathologic JJ cord-016990-ot1wi3xi 827 7 features feature NNS cord-016990-ot1wi3xi 827 8 seen see VBN cord-016990-ot1wi3xi 827 9 in in IN cord-016990-ot1wi3xi 827 10 VHF VHF NNP cord-016990-ot1wi3xi 827 11 and and CC cord-016990-ot1wi3xi 827 12 a a DT cord-016990-ot1wi3xi 827 13 variety variety NN cord-016990-ot1wi3xi 827 14 of of IN cord-016990-ot1wi3xi 827 15 other other JJ cord-016990-ot1wi3xi 827 16 viral viral JJ cord-016990-ot1wi3xi 827 17 , , , cord-016990-ot1wi3xi 827 18 rickettsial rickettsial JJ cord-016990-ot1wi3xi 827 19 , , , cord-016990-ot1wi3xi 827 20 and and CC cord-016990-ot1wi3xi 827 21 bacterial bacterial JJ cord-016990-ot1wi3xi 827 22 infections infection NNS cord-016990-ot1wi3xi 827 23 , , , cord-016990-ot1wi3xi 827 24 unequivocal unequivocal JJ cord-016990-ot1wi3xi 827 25 diagnosis diagnosis NN cord-016990-ot1wi3xi 827 26 can can MD cord-016990-ot1wi3xi 827 27 only only RB cord-016990-ot1wi3xi 827 28 be be VB cord-016990-ot1wi3xi 827 29 made make VBN cord-016990-ot1wi3xi 827 30 by by IN cord-016990-ot1wi3xi 827 31 S.R. S.R. NNP cord-016990-ot1wi3xi 827 32 Zaki Zaki NNP cord-016990-ot1wi3xi 827 33 and and CC cord-016990-ot1wi3xi 827 34 CD CD NNP cord-016990-ot1wi3xi 827 35 . . . cord-016990-ot1wi3xi 828 1 Paddock paddock NN cord-016990-ot1wi3xi 828 2 lung lung NN cord-016990-ot1wi3xi 828 3 showing show VBG cord-016990-ot1wi3xi 828 4 diffuse diffuse JJ cord-016990-ot1wi3xi 828 5 alveolar alveolar NN cord-016990-ot1wi3xi 828 6 damage damage NN cord-016990-ot1wi3xi 828 7 . . . cord-016990-ot1wi3xi 829 1 C. C. NNP cord-016990-ot1wi3xi 829 2 Using use VBG cord-016990-ot1wi3xi 829 3 immunohistochemistry immunohistochemistry NN cord-016990-ot1wi3xi 829 4 , , , cord-016990-ot1wi3xi 829 5 abundant abundant JJ cord-016990-ot1wi3xi 829 6 LCMV LCMV NNP cord-016990-ot1wi3xi 829 7 antigens antigen NNS cord-016990-ot1wi3xi 829 8 are be VBP cord-016990-ot1wi3xi 829 9 seen see VBN cord-016990-ot1wi3xi 829 10 within within IN cord-016990-ot1wi3xi 829 11 cytoplasm cytoplasm NN cord-016990-ot1wi3xi 829 12 of of IN cord-016990-ot1wi3xi 829 13 hepatocytes hepatocyte NNS cord-016990-ot1wi3xi 829 14 and and CC cord-016990-ot1wi3xi 829 15 sinusoidal sinusoidal JJ cord-016990-ot1wi3xi 829 16 lining lining NN cord-016990-ot1wi3xi 829 17 cells cell NNS cord-016990-ot1wi3xi 829 18 in in IN cord-016990-ot1wi3xi 829 19 association association NN cord-016990-ot1wi3xi 829 20 with with IN cord-016990-ot1wi3xi 829 21 areas area NNS cord-016990-ot1wi3xi 829 22 of of IN cord-016990-ot1wi3xi 829 23 hepatocellular hepatocellular JJ cord-016990-ot1wi3xi 829 24 necrosis necrosis NN cord-016990-ot1wi3xi 829 25 . . . cord-016990-ot1wi3xi 830 1 A a DT cord-016990-ot1wi3xi 830 2 , , , cord-016990-ot1wi3xi 830 3 H&E H&E NNP cord-016990-ot1wi3xi 830 4 ; ; : cord-016990-ot1wi3xi 830 5 B B NNP cord-016990-ot1wi3xi 830 6 , , , cord-016990-ot1wi3xi 830 7 C C NNP cord-016990-ot1wi3xi 830 8 , , , cord-016990-ot1wi3xi 831 1 immunoalkaline immunoalkaline JJ cord-016990-ot1wi3xi 831 2 phosphatase phosphatase NN cord-016990-ot1wi3xi 831 3 staining stain VBG cord-016990-ot1wi3xi 831 4 , , , cord-016990-ot1wi3xi 831 5 naphthol naphthol NNP cord-016990-ot1wi3xi 831 6 fast fast JJ cord-016990-ot1wi3xi 831 7 - - HYPH cord-016990-ot1wi3xi 831 8 red red NN cord-016990-ot1wi3xi 831 9 , , , cord-016990-ot1wi3xi 831 10 and and CC cord-016990-ot1wi3xi 831 11 hematoxylin hematoxylin NNP cord-016990-ot1wi3xi 831 12 counterstain counterstain NNP cord-016990-ot1wi3xi 831 13 . . . cord-016990-ot1wi3xi 832 1 laboratory laboratory NN cord-016990-ot1wi3xi 832 2 tests test NNS cord-016990-ot1wi3xi 832 3 such such JJ cord-016990-ot1wi3xi 832 4 as as IN cord-016990-ot1wi3xi 832 5 cell cell NN cord-016990-ot1wi3xi 832 6 culture culture NN cord-016990-ot1wi3xi 832 7 isolation isolation NN cord-016990-ot1wi3xi 832 8 , , , cord-016990-ot1wi3xi 832 9 serology serology NN cord-016990-ot1wi3xi 832 10 , , , cord-016990-ot1wi3xi 832 11 PCR PCR NNP cord-016990-ot1wi3xi 832 12 , , , cord-016990-ot1wi3xi 832 13 and and CC cord-016990-ot1wi3xi 832 14 lHC lHC NNS cord-016990-ot1wi3xi 832 15 ( ( -LRB- cord-016990-ot1wi3xi 832 16 Figs fig NNS cord-016990-ot1wi3xi 832 17 . . . cord-016990-ot1wi3xi 833 1 11.18D 11.18d CD cord-016990-ot1wi3xi 833 2 , , , cord-016990-ot1wi3xi 833 3 11.20C 11.20c CD cord-016990-ot1wi3xi 833 4 , , , cord-016990-ot1wi3xi 833 5 and and CC cord-016990-ot1wi3xi 833 6 11.2IB 11.2IB NNS cord-016990-ot1wi3xi 833 7 , , , cord-016990-ot1wi3xi 833 8 C C NNP cord-016990-ot1wi3xi 833 9 ) ) -RRB- cord-016990-ot1wi3xi 833 10 . . . cord-016990-ot1wi3xi 834 1 The the DT cord-016990-ot1wi3xi 834 2 principles principle NNS cord-016990-ot1wi3xi 834 3 and and CC cord-016990-ot1wi3xi 834 4 practice practice NN cord-016990-ot1wi3xi 834 5 of of IN cord-016990-ot1wi3xi 834 6 medicine medicine NN cord-016990-ot1wi3xi 834 7 Unexplained unexplained JJ cord-016990-ot1wi3xi 834 8 deaths death NNS cord-016990-ot1wi3xi 834 9 due due JJ cord-016990-ot1wi3xi 834 10 to to IN cord-016990-ot1wi3xi 834 11 possibly possibly RB cord-016990-ot1wi3xi 834 12 infectious infectious JJ cord-016990-ot1wi3xi 834 13 causes cause NNS cord-016990-ot1wi3xi 834 14 in in IN cord-016990-ot1wi3xi 834 15 the the DT cord-016990-ot1wi3xi 834 16 United United NNP cord-016990-ot1wi3xi 834 17 States States NNP cord-016990-ot1wi3xi 834 18 : : : cord-016990-ot1wi3xi 834 19 defining define VBG cord-016990-ot1wi3xi 834 20 the the DT cord-016990-ot1wi3xi 834 21 problem problem NN cord-016990-ot1wi3xi 834 22 and and CC cord-016990-ot1wi3xi 834 23 designing design VBG cord-016990-ot1wi3xi 834 24 surveillance surveillance NN cord-016990-ot1wi3xi 834 25 and and CC cord-016990-ot1wi3xi 834 26 laboratory laboratory NN cord-016990-ot1wi3xi 834 27 approaches approach NNS cord-016990-ot1wi3xi 834 28 . . . cord-016990-ot1wi3xi 835 1 The the DT cord-016990-ot1wi3xi 835 2 Unexplained unexplained JJ cord-016990-ot1wi3xi 835 3 Deaths Deaths NNPS cord-016990-ot1wi3xi 835 4 Working Working NNP cord-016990-ot1wi3xi 835 5 Group Group NNP cord-016990-ot1wi3xi 835 6 Deaths Deaths NNPS cord-016990-ot1wi3xi 835 7 : : : cord-016990-ot1wi3xi 835 8 preliminary preliminary JJ cord-016990-ot1wi3xi 835 9 data datum NNS cord-016990-ot1wi3xi 835 10 for for IN cord-016990-ot1wi3xi 835 11 The the DT cord-016990-ot1wi3xi 835 12 origin origin NN cord-016990-ot1wi3xi 835 13 of of IN cord-016990-ot1wi3xi 835 14 the the DT cord-016990-ot1wi3xi 835 15 1918 1918 CD cord-016990-ot1wi3xi 835 16 pandemic pandemic NNP cord-016990-ot1wi3xi 835 17 influenza influenza NN cord-016990-ot1wi3xi 835 18 virus virus NN cord-016990-ot1wi3xi 835 19 : : : cord-016990-ot1wi3xi 835 20 a a DT cord-016990-ot1wi3xi 835 21 continuing continue VBG cord-016990-ot1wi3xi 835 22 enigma enigma NN cord-016990-ot1wi3xi 835 23 Update update NN cord-016990-ot1wi3xi 835 24 : : : cord-016990-ot1wi3xi 835 25 Outbreak outbreak NN cord-016990-ot1wi3xi 835 26 of of IN cord-016990-ot1wi3xi 835 27 severe severe JJ cord-016990-ot1wi3xi 835 28 acute acute JJ cord-016990-ot1wi3xi 835 29 respiratory respiratory JJ cord-016990-ot1wi3xi 835 30 syndromeworldwide syndromeworldwide NN cord-016990-ot1wi3xi 835 31 Viral viral JJ cord-016990-ot1wi3xi 835 32 pneumonia pneumonia NN cord-016990-ot1wi3xi 835 33 outcome outcome NN cord-016990-ot1wi3xi 835 34 and and CC cord-016990-ot1wi3xi 835 35 prognostic prognostic JJ cord-016990-ot1wi3xi 835 36 factors factor NNS cord-016990-ot1wi3xi 835 37 in in IN cord-016990-ot1wi3xi 835 38 community community NN cord-016990-ot1wi3xi 835 39 - - HYPH cord-016990-ot1wi3xi 835 40 acquired acquire VBN cord-016990-ot1wi3xi 835 41 pneumonia pneumonia NN cord-016990-ot1wi3xi 835 42 requiring require VBG cord-016990-ot1wi3xi 835 43 hospitalization hospitalization NN cord-016990-ot1wi3xi 835 44 Hospital Hospital NNP cord-016990-ot1wi3xi 835 45 study study NN cord-016990-ot1wi3xi 835 46 of of IN cord-016990-ot1wi3xi 835 47 adult adult NN cord-016990-ot1wi3xi 835 48 community community NN cord-016990-ot1wi3xi 835 49 - - HYPH cord-016990-ot1wi3xi 835 50 acquired acquire VBN cord-016990-ot1wi3xi 835 51 pneumonia pneumonia NN cord-016990-ot1wi3xi 835 52 Adult adult NN cord-016990-ot1wi3xi 835 53 pneumonia pneumonia NN cord-016990-ot1wi3xi 835 54 in in IN cord-016990-ot1wi3xi 835 55 a a DT cord-016990-ot1wi3xi 835 56 general general JJ cord-016990-ot1wi3xi 835 57 hospital hospital NN cord-016990-ot1wi3xi 835 58 . . . cord-016990-ot1wi3xi 836 1 Etiology etiology NN cord-016990-ot1wi3xi 836 2 and and CC cord-016990-ot1wi3xi 836 3 host host NN cord-016990-ot1wi3xi 836 4 risk risk NN cord-016990-ot1wi3xi 836 5 factors factor NNS cord-016990-ot1wi3xi 837 1 Prospective prospective JJ cord-016990-ot1wi3xi 837 2 study study NN cord-016990-ot1wi3xi 837 3 of of IN cord-016990-ot1wi3xi 837 4 the the DT cord-016990-ot1wi3xi 837 5 aetiology aetiology NN cord-016990-ot1wi3xi 837 6 and and CC cord-016990-ot1wi3xi 837 7 outcome outcome NN cord-016990-ot1wi3xi 837 8 of of IN cord-016990-ot1wi3xi 837 9 pneumonia pneumonia NN cord-016990-ot1wi3xi 837 10 in in IN cord-016990-ot1wi3xi 837 11 the the DT cord-016990-ot1wi3xi 837 12 community community NN cord-016990-ot1wi3xi 837 13 Bacteria Bacteria NNS cord-016990-ot1wi3xi 837 14 , , , cord-016990-ot1wi3xi 837 15 viruses virus NNS cord-016990-ot1wi3xi 837 16 , , , cord-016990-ot1wi3xi 837 17 and and CC cord-016990-ot1wi3xi 837 18 mycoplasmas mycoplasmas NN cord-016990-ot1wi3xi 837 19 in in IN cord-016990-ot1wi3xi 837 20 acute acute JJ cord-016990-ot1wi3xi 837 21 pneumonia pneumonia NN cord-016990-ot1wi3xi 837 22 in in IN cord-016990-ot1wi3xi 837 23 adults adult NNS cord-016990-ot1wi3xi 838 1 Viral viral JJ cord-016990-ot1wi3xi 838 2 communityacquired communityacquired JJ cord-016990-ot1wi3xi 838 3 pneumonia pneumonia NN cord-016990-ot1wi3xi 838 4 in in IN cord-016990-ot1wi3xi 838 5 nonimmunocompromised nonimmunocompromise VBN cord-016990-ot1wi3xi 838 6 adults adult NNS cord-016990-ot1wi3xi 839 1 A a DT cord-016990-ot1wi3xi 839 2 novel novel JJ cord-016990-ot1wi3xi 839 3 coronavirus coronavirus NN cord-016990-ot1wi3xi 839 4 associated associate VBN cord-016990-ot1wi3xi 839 5 with with IN cord-016990-ot1wi3xi 839 6 severe severe JJ cord-016990-ot1wi3xi 839 7 acute acute JJ cord-016990-ot1wi3xi 839 8 respiratory respiratory JJ cord-016990-ot1wi3xi 839 9 syndrome syndrome NN cord-016990-ot1wi3xi 839 10 Approach Approach NNP cord-016990-ot1wi3xi 839 11 to to IN cord-016990-ot1wi3xi 839 12 the the DT cord-016990-ot1wi3xi 839 13 patient patient NN cord-016990-ot1wi3xi 839 14 with with IN cord-016990-ot1wi3xi 839 15 pneumonia pneumonia NN cord-016990-ot1wi3xi 840 1 How how WRB cord-016990-ot1wi3xi 840 2 do do VBP cord-016990-ot1wi3xi 840 3 viral viral JJ cord-016990-ot1wi3xi 840 4 infections infection NNS cord-016990-ot1wi3xi 840 5 predispose predispose VBP cord-016990-ot1wi3xi 840 6 patients patient NNS cord-016990-ot1wi3xi 840 7 to to IN cord-016990-ot1wi3xi 840 8 bacterial bacterial JJ cord-016990-ot1wi3xi 840 9 infections infection NNS cord-016990-ot1wi3xi 840 10 ? ? . cord-016990-ot1wi3xi 841 1 Preceding precede VBG cord-016990-ot1wi3xi 841 2 respiratory respiratory JJ cord-016990-ot1wi3xi 841 3 infection infection NN cord-016990-ot1wi3xi 841 4 predisposing predispose VBG cord-016990-ot1wi3xi 841 5 for for IN cord-016990-ot1wi3xi 841 6 primary primary JJ cord-016990-ot1wi3xi 841 7 and and CC cord-016990-ot1wi3xi 841 8 secondary secondary JJ cord-016990-ot1wi3xi 841 9 invasive invasive JJ cord-016990-ot1wi3xi 841 10 Haemophilus haemophilus NN cord-016990-ot1wi3xi 841 11 influenzae influenzae NN cord-016990-ot1wi3xi 841 12 type type NN cord-016990-ot1wi3xi 841 13 b b NN cord-016990-ot1wi3xi 841 14 disease disease NN cord-016990-ot1wi3xi 841 15 Viral viral JJ cord-016990-ot1wi3xi 841 16 - - HYPH cord-016990-ot1wi3xi 841 17 bacterial bacterial JJ cord-016990-ot1wi3xi 841 18 synergistic synergistic JJ cord-016990-ot1wi3xi 841 19 interaction interaction NN cord-016990-ot1wi3xi 841 20 in in IN cord-016990-ot1wi3xi 841 21 respiratory respiratory JJ cord-016990-ot1wi3xi 841 22 disease disease NN cord-016990-ot1wi3xi 841 23 Immune immune JJ cord-016990-ot1wi3xi 841 24 impairment impairment NN cord-016990-ot1wi3xi 841 25 of of IN cord-016990-ot1wi3xi 841 26 alveolar alveolar JJ cord-016990-ot1wi3xi 841 27 macrophage macrophage NN cord-016990-ot1wi3xi 841 28 phagocytosis phagocytosis NN cord-016990-ot1wi3xi 841 29 during during IN cord-016990-ot1wi3xi 841 30 influenza influenza NN cord-016990-ot1wi3xi 841 31 virus virus NN cord-016990-ot1wi3xi 841 32 pneumonia pneumonia NN cord-016990-ot1wi3xi 841 33 Mechanisms Mechanisms NNPS cord-016990-ot1wi3xi 841 34 of of IN cord-016990-ot1wi3xi 841 35 bacterial bacterial JJ cord-016990-ot1wi3xi 841 36 superinfect superinfect NN cord-016990-ot1wi3xi 841 37 ions ion NNS cord-016990-ot1wi3xi 841 38 in in IN cord-016990-ot1wi3xi 841 39 viral viral JJ cord-016990-ot1wi3xi 841 40 pneumonias pneumonia NNS cord-016990-ot1wi3xi 841 41 Impact impact NN cord-016990-ot1wi3xi 841 42 of of IN cord-016990-ot1wi3xi 841 43 respiratory respiratory JJ cord-016990-ot1wi3xi 841 44 virus virus NN cord-016990-ot1wi3xi 841 45 infections infection NNS cord-016990-ot1wi3xi 841 46 on on IN cord-016990-ot1wi3xi 841 47 persons person NNS cord-016990-ot1wi3xi 841 48 with with IN cord-016990-ot1wi3xi 841 49 chronic chronic JJ cord-016990-ot1wi3xi 841 50 underlying underlying JJ cord-016990-ot1wi3xi 841 51 conditions condition NNS cord-016990-ot1wi3xi 841 52 Identification identification NN cord-016990-ot1wi3xi 841 53 of of IN cord-016990-ot1wi3xi 841 54 a a DT cord-016990-ot1wi3xi 841 55 new new JJ cord-016990-ot1wi3xi 841 56 North north JJ cord-016990-ot1wi3xi 841 57 American american JJ cord-016990-ot1wi3xi 841 58 hantavirus hantavirus NN cord-016990-ot1wi3xi 841 59 that that WDT cord-016990-ot1wi3xi 841 60 causes cause VBZ cord-016990-ot1wi3xi 841 61 acute acute JJ cord-016990-ot1wi3xi 841 62 pulmonary pulmonary JJ cord-016990-ot1wi3xi 841 63 insufficiency insufficiency NN cord-016990-ot1wi3xi 842 1 Nipah Nipah NNP cord-016990-ot1wi3xi 842 2 virus virus NN cord-016990-ot1wi3xi 842 3 : : : cord-016990-ot1wi3xi 842 4 a a DT cord-016990-ot1wi3xi 842 5 recently recently RB cord-016990-ot1wi3xi 842 6 emergent emergent JJ cord-016990-ot1wi3xi 842 7 deadly deadly JJ cord-016990-ot1wi3xi 842 8 paramyxovirus paramyxovirus JJ cord-016990-ot1wi3xi 842 9 Genetic genetic JJ cord-016990-ot1wi3xi 842 10 identification identification NN cord-016990-ot1wi3xi 842 11 of of IN cord-016990-ot1wi3xi 842 12 a a DT cord-016990-ot1wi3xi 842 13 hantavirus hantavirus NN cord-016990-ot1wi3xi 842 14 associated associate VBN cord-016990-ot1wi3xi 842 15 with with IN cord-016990-ot1wi3xi 842 16 an an DT cord-016990-ot1wi3xi 842 17 outbreak outbreak NN cord-016990-ot1wi3xi 842 18 of of IN cord-016990-ot1wi3xi 842 19 acute acute JJ cord-016990-ot1wi3xi 842 20 respiratory respiratory JJ cord-016990-ot1wi3xi 842 21 illness illness NN cord-016990-ot1wi3xi 842 22 Varicella varicella NN cord-016990-ot1wi3xi 842 23 - - HYPH cord-016990-ot1wi3xi 842 24 related relate VBN cord-016990-ot1wi3xi 842 25 mortality mortality NN cord-016990-ot1wi3xi 842 26 in in IN cord-016990-ot1wi3xi 842 27 California California NNP cord-016990-ot1wi3xi 842 28 Decline decline VBP cord-016990-ot1wi3xi 842 29 in in IN cord-016990-ot1wi3xi 842 30 mortality mortality NN cord-016990-ot1wi3xi 842 31 due due IN cord-016990-ot1wi3xi 842 32 to to IN cord-016990-ot1wi3xi 842 33 varicella varicella NN cord-016990-ot1wi3xi 842 34 after after IN cord-016990-ot1wi3xi 842 35 implementation implementation NN cord-016990-ot1wi3xi 842 36 of of IN cord-016990-ot1wi3xi 842 37 varicella varicella NN cord-016990-ot1wi3xi 842 38 vaccination vaccination NN cord-016990-ot1wi3xi 842 39 in in IN cord-016990-ot1wi3xi 842 40 the the DT cord-016990-ot1wi3xi 842 41 United United NNP cord-016990-ot1wi3xi 842 42 States States NNP cord-016990-ot1wi3xi 842 43 Pneumonia Pneumonia NNP cord-016990-ot1wi3xi 842 44 caused cause VBN cord-016990-ot1wi3xi 842 45 by by IN cord-016990-ot1wi3xi 842 46 herpesviruses herpesviruses NNP cord-016990-ot1wi3xi 842 47 in in IN cord-016990-ot1wi3xi 842 48 recipients recipient NNS cord-016990-ot1wi3xi 842 49 of of IN cord-016990-ot1wi3xi 842 50 hematopoietic hematopoietic JJ cord-016990-ot1wi3xi 842 51 cell cell NN cord-016990-ot1wi3xi 842 52 transplants transplant NNS cord-016990-ot1wi3xi 843 1 Initial initial JJ cord-016990-ot1wi3xi 843 2 genetic genetic JJ cord-016990-ot1wi3xi 843 3 characterization characterization NN cord-016990-ot1wi3xi 843 4 of of IN cord-016990-ot1wi3xi 843 5 the the DT cord-016990-ot1wi3xi 843 6 1918 1918 CD cord-016990-ot1wi3xi 843 7 " " `` cord-016990-ot1wi3xi 843 8 Spanish spanish JJ cord-016990-ot1wi3xi 843 9 " " '' cord-016990-ot1wi3xi 843 10 influenza influenza NN cord-016990-ot1wi3xi 843 11 virus virus NN cord-016990-ot1wi3xi 843 12 Characterization characterization NN cord-016990-ot1wi3xi 843 13 of of IN cord-016990-ot1wi3xi 843 14 the the DT cord-016990-ot1wi3xi 843 15 reconstructed reconstruct VBN cord-016990-ot1wi3xi 843 16 1918 1918 CD cord-016990-ot1wi3xi 843 17 Spanish spanish JJ cord-016990-ot1wi3xi 843 18 influenza influenza NN cord-016990-ot1wi3xi 843 19 pandemic pandemic NN cord-016990-ot1wi3xi 843 20 virus virus NN cord-016990-ot1wi3xi 843 21 Transmission transmission NN cord-016990-ot1wi3xi 843 22 of of IN cord-016990-ot1wi3xi 843 23 lymphocytic lymphocytic JJ cord-016990-ot1wi3xi 843 24 choriomeningitis choriomeningitis NNP cord-016990-ot1wi3xi 843 25 virus virus NN cord-016990-ot1wi3xi 843 26 by by IN cord-016990-ot1wi3xi 843 27 organ organ NN cord-016990-ot1wi3xi 843 28 transplantation transplantation NN cord-016990-ot1wi3xi 844 1 A a DT cord-016990-ot1wi3xi 844 2 morbillivirus morbillivirus NNP cord-016990-ot1wi3xi 844 3 that that WDT cord-016990-ot1wi3xi 844 4 caused cause VBD cord-016990-ot1wi3xi 844 5 fatal fatal JJ cord-016990-ot1wi3xi 844 6 disease disease NN cord-016990-ot1wi3xi 844 7 in in IN cord-016990-ot1wi3xi 844 8 horses horse NNS cord-016990-ot1wi3xi 844 9 and and CC cord-016990-ot1wi3xi 844 10 humans human NNS cord-016990-ot1wi3xi 844 11 Fatal fatal JJ cord-016990-ot1wi3xi 844 12 West West NNP cord-016990-ot1wi3xi 844 13 Nile Nile NNP cord-016990-ot1wi3xi 844 14 virus virus NN cord-016990-ot1wi3xi 844 15 encephalitis encephalitis RB cord-016990-ot1wi3xi 844 16 in in IN cord-016990-ot1wi3xi 844 17 a a DT cord-016990-ot1wi3xi 844 18 renal renal JJ cord-016990-ot1wi3xi 844 19 transplant transplant NN cord-016990-ot1wi3xi 844 20 recipient recipient NN cord-016990-ot1wi3xi 844 21 Transmission Transmission NNP cord-016990-ot1wi3xi 844 22 of of IN cord-016990-ot1wi3xi 844 23 West West NNP cord-016990-ot1wi3xi 844 24 Nile Nile NNP cord-016990-ot1wi3xi 844 25 virus virus NN cord-016990-ot1wi3xi 844 26 from from IN cord-016990-ot1wi3xi 844 27 an an DT cord-016990-ot1wi3xi 844 28 organ organ NN cord-016990-ot1wi3xi 844 29 donor donor NN cord-016990-ot1wi3xi 844 30 to to IN cord-016990-ot1wi3xi 844 31 four four CD cord-016990-ot1wi3xi 844 32 transplant transplant NN cord-016990-ot1wi3xi 844 33 recipients recipient NNS cord-016990-ot1wi3xi 844 34 Transmission Transmission NNP cord-016990-ot1wi3xi 844 35 of of IN cord-016990-ot1wi3xi 844 36 rabies rabies NN cord-016990-ot1wi3xi 844 37 virus virus NN cord-016990-ot1wi3xi 844 38 from from IN cord-016990-ot1wi3xi 844 39 an an DT cord-016990-ot1wi3xi 844 40 organ organ NN cord-016990-ot1wi3xi 844 41 donor donor NN cord-016990-ot1wi3xi 844 42 to to IN cord-016990-ot1wi3xi 844 43 four four CD cord-016990-ot1wi3xi 844 44 transplant transplant NN cord-016990-ot1wi3xi 844 45 recipients recipient NNS cord-016990-ot1wi3xi 844 46 Isolation isolation NN cord-016990-ot1wi3xi 844 47 of of IN cord-016990-ot1wi3xi 844 48 a a DT cord-016990-ot1wi3xi 844 49 cytopathogenic cytopathogenic JJ cord-016990-ot1wi3xi 844 50 agent agent NN cord-016990-ot1wi3xi 844 51 from from IN cord-016990-ot1wi3xi 844 52 human human JJ cord-016990-ot1wi3xi 844 53 adenoids adenoid NNS cord-016990-ot1wi3xi 844 54 undergoing undergo VBG cord-016990-ot1wi3xi 844 55 spontaneous spontaneous JJ cord-016990-ot1wi3xi 844 56 degeneration degeneration NN cord-016990-ot1wi3xi 844 57 in in IN cord-016990-ot1wi3xi 844 58 tissue tissue NN cord-016990-ot1wi3xi 844 59 culture culture NN cord-016990-ot1wi3xi 844 60 Recovery recovery NN cord-016990-ot1wi3xi 844 61 of of IN cord-016990-ot1wi3xi 844 62 new new JJ cord-016990-ot1wi3xi 844 63 agent agent NN cord-016990-ot1wi3xi 844 64 from from IN cord-016990-ot1wi3xi 844 65 patients patient NNS cord-016990-ot1wi3xi 844 66 with with IN cord-016990-ot1wi3xi 844 67 acute acute JJ cord-016990-ot1wi3xi 844 68 respiratory respiratory JJ cord-016990-ot1wi3xi 844 69 illness illness NN cord-016990-ot1wi3xi 844 70 Adenoviruses adenovirus NNS cord-016990-ot1wi3xi 844 71 : : : cord-016990-ot1wi3xi 844 72 group group NN cord-016990-ot1wi3xi 844 73 name name NN cord-016990-ot1wi3xi 844 74 proposed propose VBN cord-016990-ot1wi3xi 844 75 for for IN cord-016990-ot1wi3xi 844 76 new new JJ cord-016990-ot1wi3xi 844 77 respiratory respiratory JJ cord-016990-ot1wi3xi 844 78 - - HYPH cord-016990-ot1wi3xi 844 79 tract tract NN cord-016990-ot1wi3xi 844 80 viruses virus NNS cord-016990-ot1wi3xi 844 81 Adenoviruses adenovirus NNS cord-016990-ot1wi3xi 844 82 in in IN cord-016990-ot1wi3xi 844 83 the the DT cord-016990-ot1wi3xi 844 84 immunocompromised immunocompromised JJ cord-016990-ot1wi3xi 844 85 host host NN cord-016990-ot1wi3xi 844 86 Fatal fatal JJ cord-016990-ot1wi3xi 844 87 disseminated disseminate VBD cord-016990-ot1wi3xi 844 88 adenovirus adenovirus NN cord-016990-ot1wi3xi 844 89 infections infection NNS cord-016990-ot1wi3xi 844 90 in in IN cord-016990-ot1wi3xi 844 91 immunocompromised immunocompromised JJ cord-016990-ot1wi3xi 844 92 patients patient NNS cord-016990-ot1wi3xi 844 93 Respiratory respiratory JJ cord-016990-ot1wi3xi 844 94 disease disease NN cord-016990-ot1wi3xi 844 95 and and CC cord-016990-ot1wi3xi 844 96 the the DT cord-016990-ot1wi3xi 844 97 adenoviruses adenovirus NNS cord-016990-ot1wi3xi 844 98 Adenoviruses adenovirus NNS cord-016990-ot1wi3xi 844 99 from from IN cord-016990-ot1wi3xi 844 100 human human JJ cord-016990-ot1wi3xi 844 101 immunodeficiency immunodeficiency NN cord-016990-ot1wi3xi 844 102 virus virus NN cord-016990-ot1wi3xi 844 103 - - HYPH cord-016990-ot1wi3xi 844 104 infected infect VBN cord-016990-ot1wi3xi 844 105 individuals individual NNS cord-016990-ot1wi3xi 844 106 , , , cord-016990-ot1wi3xi 844 107 including include VBG cord-016990-ot1wi3xi 844 108 two two CD cord-016990-ot1wi3xi 844 109 strains strain NNS cord-016990-ot1wi3xi 844 110 that that WDT cord-016990-ot1wi3xi 844 111 represent represent VBP cord-016990-ot1wi3xi 844 112 new new JJ cord-016990-ot1wi3xi 844 113 candidate candidate NN cord-016990-ot1wi3xi 844 114 serotypes serotype NNS cord-016990-ot1wi3xi 844 115 Ad50 ad50 NN cord-016990-ot1wi3xi 844 116 and and CC cord-016990-ot1wi3xi 844 117 Ad51 Ad51 NNP cord-016990-ot1wi3xi 844 118 of of IN cord-016990-ot1wi3xi 844 119 species specie NNS cord-016990-ot1wi3xi 844 120 Bl Bl NNP cord-016990-ot1wi3xi 844 121 and and CC cord-016990-ot1wi3xi 844 122 D d NN cord-016990-ot1wi3xi 844 123 , , , cord-016990-ot1wi3xi 844 124 respectively respectively RB cord-016990-ot1wi3xi 844 125 Infections infection NNS cord-016990-ot1wi3xi 844 126 in in IN cord-016990-ot1wi3xi 844 127 18,000 18,000 CD cord-016990-ot1wi3xi 844 128 infants infant NNS cord-016990-ot1wi3xi 844 129 and and CC cord-016990-ot1wi3xi 844 130 children child NNS cord-016990-ot1wi3xi 844 131 in in IN cord-016990-ot1wi3xi 844 132 a a DT cord-016990-ot1wi3xi 844 133 controlled control VBN cord-016990-ot1wi3xi 844 134 study study NN cord-016990-ot1wi3xi 844 135 of of IN cord-016990-ot1wi3xi 844 136 respiratory respiratory JJ cord-016990-ot1wi3xi 844 137 tract tract NN cord-016990-ot1wi3xi 844 138 disease disease NN cord-016990-ot1wi3xi 844 139 . . . cord-016990-ot1wi3xi 845 1 1 1 LS cord-016990-ot1wi3xi 845 2 . . . cord-016990-ot1wi3xi 846 1 Adenovirus Adenovirus NNP cord-016990-ot1wi3xi 846 2 pathogenicity pathogenicity NN cord-016990-ot1wi3xi 846 3 in in IN cord-016990-ot1wi3xi 846 4 relation relation NN cord-016990-ot1wi3xi 846 5 to to IN cord-016990-ot1wi3xi 846 6 serologic serologic JJ cord-016990-ot1wi3xi 846 7 type type NN cord-016990-ot1wi3xi 846 8 and and CC cord-016990-ot1wi3xi 846 9 illness illness NN cord-016990-ot1wi3xi 846 10 syndrome syndrome NN cord-016990-ot1wi3xi 846 11 Adenoviral Adenoviral NNP cord-016990-ot1wi3xi 846 12 diseases disease NNS cord-016990-ot1wi3xi 846 13 in in IN cord-016990-ot1wi3xi 846 14 children child NNS cord-016990-ot1wi3xi 846 15 : : : cord-016990-ot1wi3xi 846 16 a a DT cord-016990-ot1wi3xi 846 17 study study NN cord-016990-ot1wi3xi 846 18 of of IN cord-016990-ot1wi3xi 846 19 105 105 CD cord-016990-ot1wi3xi 846 20 hospital hospital NN cord-016990-ot1wi3xi 846 21 cases case NNS cord-016990-ot1wi3xi 846 22 Adenovirus Adenovirus NNP cord-016990-ot1wi3xi 846 23 type type NN cord-016990-ot1wi3xi 846 24 7 7 CD cord-016990-ot1wi3xi 846 25 associated associate VBN cord-016990-ot1wi3xi 846 26 with with IN cord-016990-ot1wi3xi 846 27 severe severe JJ cord-016990-ot1wi3xi 846 28 and and CC cord-016990-ot1wi3xi 846 29 fatal fatal JJ cord-016990-ot1wi3xi 846 30 acute acute JJ cord-016990-ot1wi3xi 846 31 lower low JJR cord-016990-ot1wi3xi 846 32 respiratory respiratory JJ cord-016990-ot1wi3xi 846 33 infections infection NNS cord-016990-ot1wi3xi 846 34 in in IN cord-016990-ot1wi3xi 846 35 Argentine argentine JJ cord-016990-ot1wi3xi 846 36 children child NNS cord-016990-ot1wi3xi 846 37 Wasz Wasz NNP cord-016990-ot1wi3xi 846 38 - - HYPH cord-016990-ot1wi3xi 846 39 Hockert Hockert NNP cord-016990-ot1wi3xi 846 40 0 0 CD cord-016990-ot1wi3xi 846 41 . . . cord-016990-ot1wi3xi 847 1 Type type NN cord-016990-ot1wi3xi 847 2 7 7 CD cord-016990-ot1wi3xi 847 3 adenovirus adenovirus NN cord-016990-ot1wi3xi 847 4 pneumonia pneumonia NN cord-016990-ot1wi3xi 847 5 Bronchopneumonia Bronchopneumonia NNP cord-016990-ot1wi3xi 847 6 with with IN cord-016990-ot1wi3xi 847 7 serious serious JJ cord-016990-ot1wi3xi 847 8 sequelae sequela NNS cord-016990-ot1wi3xi 847 9 in in IN cord-016990-ot1wi3xi 847 10 children child NNS cord-016990-ot1wi3xi 847 11 with with IN cord-016990-ot1wi3xi 847 12 evidence evidence NN cord-016990-ot1wi3xi 847 13 of of IN cord-016990-ot1wi3xi 847 14 adenovirus adenovirus NN cord-016990-ot1wi3xi 847 15 type type NN cord-016990-ot1wi3xi 847 16 21 21 CD cord-016990-ot1wi3xi 847 17 infection infection NN cord-016990-ot1wi3xi 847 18 Disseminated disseminate VBD cord-016990-ot1wi3xi 847 19 adenovirus adenovirus NN cord-016990-ot1wi3xi 847 20 disease disease NN cord-016990-ot1wi3xi 847 21 in in IN cord-016990-ot1wi3xi 847 22 immunocompromised immunocompromised JJ cord-016990-ot1wi3xi 847 23 and and CC cord-016990-ot1wi3xi 847 24 immunocompetent immunocompetent JJ cord-016990-ot1wi3xi 847 25 children child NNS cord-016990-ot1wi3xi 847 26 Adenovirus Adenovirus NNP cord-016990-ot1wi3xi 847 27 pneumonia pneumonia NN cord-016990-ot1wi3xi 847 28 Fatal fatal JJ cord-016990-ot1wi3xi 847 29 pneumonia pneumonia NN cord-016990-ot1wi3xi 847 30 associated associate VBN cord-016990-ot1wi3xi 847 31 with with IN cord-016990-ot1wi3xi 847 32 adenovirus adenovirus NN cord-016990-ot1wi3xi 847 33 type type NN cord-016990-ot1wi3xi 847 34 7 7 CD cord-016990-ot1wi3xi 847 35 in in IN cord-016990-ot1wi3xi 847 36 three three CD cord-016990-ot1wi3xi 847 37 military military JJ cord-016990-ot1wi3xi 847 38 trainees trainee NNS cord-016990-ot1wi3xi 847 39 Two two CD cord-016990-ot1wi3xi 847 40 fatal fatal JJ cord-016990-ot1wi3xi 847 41 cases case NNS cord-016990-ot1wi3xi 847 42 of of IN cord-016990-ot1wi3xi 847 43 adenovirus adenovirus NN cord-016990-ot1wi3xi 847 44 - - HYPH cord-016990-ot1wi3xi 847 45 related relate VBN cord-016990-ot1wi3xi 847 46 illness illness NN cord-016990-ot1wi3xi 847 47 in in IN cord-016990-ot1wi3xi 847 48 previously previously RB cord-016990-ot1wi3xi 847 49 healthy healthy JJ cord-016990-ot1wi3xi 847 50 young young JJ cord-016990-ot1wi3xi 847 51 adults adult NNS cord-016990-ot1wi3xi 847 52 - - : cord-016990-ot1wi3xi 847 53 Illinois Illinois NNP cord-016990-ot1wi3xi 847 54 Histopathology Histopathology NNP cord-016990-ot1wi3xi 847 55 of of IN cord-016990-ot1wi3xi 847 56 fatal fatal JJ cord-016990-ot1wi3xi 847 57 adenovirus adenovirus NN cord-016990-ot1wi3xi 847 58 infection infection NN cord-016990-ot1wi3xi 847 59 of of IN cord-016990-ot1wi3xi 847 60 the the DT cord-016990-ot1wi3xi 847 61 respiratory respiratory JJ cord-016990-ot1wi3xi 847 62 tract tract NN cord-016990-ot1wi3xi 847 63 in in IN cord-016990-ot1wi3xi 847 64 young young JJ cord-016990-ot1wi3xi 847 65 children child NNS cord-016990-ot1wi3xi 848 1 Adenovirus Adenovirus NNP cord-016990-ot1wi3xi 848 2 pneumonia pneumonia NN cord-016990-ot1wi3xi 848 3 in in IN cord-016990-ot1wi3xi 848 4 lung lung NN cord-016990-ot1wi3xi 848 5 transplant transplant NN cord-016990-ot1wi3xi 848 6 recipients recipient NNS cord-016990-ot1wi3xi 848 7 Cytologic Cytologic NNP cord-016990-ot1wi3xi 848 8 diagnosis diagnosis NN cord-016990-ot1wi3xi 848 9 of of IN cord-016990-ot1wi3xi 848 10 adenovirus adenovirus NN cord-016990-ot1wi3xi 848 11 bronchopneumonia bronchopneumonia NN cord-016990-ot1wi3xi 848 12 Adenoviral Adenoviral NNP cord-016990-ot1wi3xi 848 13 infections infection NNS cord-016990-ot1wi3xi 848 14 in in IN cord-016990-ot1wi3xi 848 15 children child NNS cord-016990-ot1wi3xi 848 16 : : : cord-016990-ot1wi3xi 848 17 the the DT cord-016990-ot1wi3xi 848 18 impact impact NN cord-016990-ot1wi3xi 848 19 of of IN cord-016990-ot1wi3xi 848 20 rapid rapid JJ cord-016990-ot1wi3xi 848 21 diagnosis diagnosis NN cord-016990-ot1wi3xi 848 22 Report Report NNP cord-016990-ot1wi3xi 848 23 of of IN cord-016990-ot1wi3xi 848 24 one one CD cord-016990-ot1wi3xi 848 25 case case NN cord-016990-ot1wi3xi 848 26 and and CC cord-016990-ot1wi3xi 848 27 S.R. S.R. NNP cord-016990-ot1wi3xi 848 28 Zaki Zaki NNP cord-016990-ot1wi3xi 848 29 and and CC cord-016990-ot1wi3xi 848 30 c. c. NNP cord-016990-ot1wi3xi 849 1 D. D. NNP cord-016990-ot1wi3xi 849 2 Paddock Paddock NNP cord-016990-ot1wi3xi 849 3 review review NN cord-016990-ot1wi3xi 849 4 of of IN cord-016990-ot1wi3xi 849 5 the the DT cord-016990-ot1wi3xi 849 6 literature literature NN cord-016990-ot1wi3xi 849 7 Morphological morphological JJ cord-016990-ot1wi3xi 849 8 and and CC cord-016990-ot1wi3xi 849 9 virological virological JJ cord-016990-ot1wi3xi 849 10 studies study NNS cord-016990-ot1wi3xi 849 11 in in IN cord-016990-ot1wi3xi 849 12 six six CD cord-016990-ot1wi3xi 849 13 autopsies autopsy NNS cord-016990-ot1wi3xi 849 14 of of IN cord-016990-ot1wi3xi 849 15 children child NNS cord-016990-ot1wi3xi 849 16 with with IN cord-016990-ot1wi3xi 849 17 adenovirus adenovirus NN cord-016990-ot1wi3xi 849 18 pneumonia pneumonia NN cord-016990-ot1wi3xi 849 19 Antigenic antigenic JJ cord-016990-ot1wi3xi 849 20 relationships relationship NNS cord-016990-ot1wi3xi 849 21 among among IN cord-016990-ot1wi3xi 849 22 the the DT cord-016990-ot1wi3xi 849 23 47 47 CD cord-016990-ot1wi3xi 849 24 human human JJ cord-016990-ot1wi3xi 849 25 adenoviruses adenovirus NNS cord-016990-ot1wi3xi 849 26 determined determine VBN cord-016990-ot1wi3xi 849 27 in in IN cord-016990-ot1wi3xi 849 28 reference reference NN cord-016990-ot1wi3xi 849 29 horse horse NN cord-016990-ot1wi3xi 849 30 antisera antisera NNP cord-016990-ot1wi3xi 850 1 The the DT cord-016990-ot1wi3xi 850 2 polymerase polymerase NN cord-016990-ot1wi3xi 850 3 chain chain NN cord-016990-ot1wi3xi 850 4 reaction reaction NN cord-016990-ot1wi3xi 850 5 for for IN cord-016990-ot1wi3xi 850 6 detecting detect VBG cord-016990-ot1wi3xi 850 7 adenovirus adenovirus NN cord-016990-ot1wi3xi 850 8 DNA dna NN cord-016990-ot1wi3xi 850 9 in in IN cord-016990-ot1wi3xi 850 10 formalin formalin NN cord-016990-ot1wi3xi 850 11 - - HYPH cord-016990-ot1wi3xi 850 12 fixed fix VBN cord-016990-ot1wi3xi 850 13 , , , cord-016990-ot1wi3xi 850 14 paraffin paraffin NN cord-016990-ot1wi3xi 850 15 - - HYPH cord-016990-ot1wi3xi 850 16 embedded embed VBN cord-016990-ot1wi3xi 850 17 tissue tissue NN cord-016990-ot1wi3xi 850 18 obtained obtain VBN cord-016990-ot1wi3xi 850 19 post post FW cord-016990-ot1wi3xi 850 20 mortem mortem NN cord-016990-ot1wi3xi 850 21 Prevention prevention NN cord-016990-ot1wi3xi 850 22 of of IN cord-016990-ot1wi3xi 850 23 bleomycin bleomycin NN cord-016990-ot1wi3xi 850 24 - - HYPH cord-016990-ot1wi3xi 850 25 induced induce VBN cord-016990-ot1wi3xi 850 26 pulmonary pulmonary JJ cord-016990-ot1wi3xi 850 27 fibrosis fibrosis NN cord-016990-ot1wi3xi 850 28 after after IN cord-016990-ot1wi3xi 850 29 adenovirusmediated adenovirusmediated JJ cord-016990-ot1wi3xi 850 30 transfer transfer NN cord-016990-ot1wi3xi 850 31 of of IN cord-016990-ot1wi3xi 850 32 the the DT cord-016990-ot1wi3xi 850 33 bacterial bacterial JJ cord-016990-ot1wi3xi 850 34 bleomycin bleomycin NN cord-016990-ot1wi3xi 850 35 resistance resistance NN cord-016990-ot1wi3xi 850 36 gene gene NN cord-016990-ot1wi3xi 850 37 Manual Manual NNP cord-016990-ot1wi3xi 850 38 of of IN cord-016990-ot1wi3xi 850 39 clinical clinical JJ cord-016990-ot1wi3xi 850 40 microbiology microbiology NN cord-016990-ot1wi3xi 850 41 Nucleotide Nucleotide NNP cord-016990-ot1wi3xi 850 42 sequence sequence NN cord-016990-ot1wi3xi 850 43 of of IN cord-016990-ot1wi3xi 850 44 the the DT cord-016990-ot1wi3xi 850 45 L L NNP cord-016990-ot1wi3xi 850 46 genome genome NN cord-016990-ot1wi3xi 850 47 segment segment NN cord-016990-ot1wi3xi 850 48 of of IN cord-016990-ot1wi3xi 850 49 Hantaan Hantaan NNP cord-016990-ot1wi3xi 850 50 virus virus NN cord-016990-ot1wi3xi 850 51 Analysis Analysis NNP cord-016990-ot1wi3xi 850 52 of of IN cord-016990-ot1wi3xi 850 53 Hantaan Hantaan NNP cord-016990-ot1wi3xi 850 54 virus virus NN cord-016990-ot1wi3xi 850 55 RNA rna NN cord-016990-ot1wi3xi 850 56 : : : cord-016990-ot1wi3xi 850 57 evidence evidence NN cord-016990-ot1wi3xi 850 58 for for IN cord-016990-ot1wi3xi 850 59 a a DT cord-016990-ot1wi3xi 850 60 new new JJ cord-016990-ot1wi3xi 850 61 genus genus NN cord-016990-ot1wi3xi 850 62 of of IN cord-016990-ot1wi3xi 850 63 bunyaviridae bunyaviridae VBN cord-016990-ot1wi3xi 850 64 Phylogenetic phylogenetic JJ cord-016990-ot1wi3xi 850 65 analyses analysis NNS cord-016990-ot1wi3xi 850 66 of of IN cord-016990-ot1wi3xi 850 67 virus virus NN cord-016990-ot1wi3xi 850 68 isolates isolate VBZ cord-016990-ot1wi3xi 850 69 in in IN cord-016990-ot1wi3xi 850 70 the the DT cord-016990-ot1wi3xi 850 71 genus genus NN cord-016990-ot1wi3xi 850 72 Hantavirus Hantavirus NNP cord-016990-ot1wi3xi 850 73 , , , cord-016990-ot1wi3xi 850 74 family family NN cord-016990-ot1wi3xi 850 75 Bunyaviridae Bunyaviridae NNP cord-016990-ot1wi3xi 850 76 Morphology morphology NN cord-016990-ot1wi3xi 850 77 and and CC cord-016990-ot1wi3xi 850 78 morphogenesis morphogenesis NN cord-016990-ot1wi3xi 850 79 of of IN cord-016990-ot1wi3xi 850 80 viruses virus NNS cord-016990-ot1wi3xi 850 81 of of IN cord-016990-ot1wi3xi 850 82 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 850 83 fever fever NN cord-016990-ot1wi3xi 850 84 with with IN cord-016990-ot1wi3xi 850 85 renal renal JJ cord-016990-ot1wi3xi 850 86 syndrome syndrome NN cord-016990-ot1wi3xi 850 87 : : : cord-016990-ot1wi3xi 850 88 inclusion inclusion NN cord-016990-ot1wi3xi 850 89 bodies body NNS cord-016990-ot1wi3xi 850 90 - - : cord-016990-ot1wi3xi 850 91 ultrastructure ultrastructure NN cord-016990-ot1wi3xi 850 92 marker marker NN cord-016990-ot1wi3xi 850 93 of of IN cord-016990-ot1wi3xi 850 94 hantavirus hantavirus NN cord-016990-ot1wi3xi 850 95 - - HYPH cord-016990-ot1wi3xi 850 96 infected infect VBN cord-016990-ot1wi3xi 850 97 cells cell NNS cord-016990-ot1wi3xi 851 1 Ultrastructural ultrastructural JJ cord-016990-ot1wi3xi 851 2 characteristics characteristic NNS cord-016990-ot1wi3xi 851 3 of of IN cord-016990-ot1wi3xi 851 4 Sin Sin NNP cord-016990-ot1wi3xi 851 5 Nombre Nombre NNP cord-016990-ot1wi3xi 851 6 virus virus NN cord-016990-ot1wi3xi 851 7 , , , cord-016990-ot1wi3xi 851 8 causative causative JJ cord-016990-ot1wi3xi 851 9 agent agent NN cord-016990-ot1wi3xi 851 10 of of IN cord-016990-ot1wi3xi 851 11 hantavirus hantavirus NNP cord-016990-ot1wi3xi 851 12 pulmonary pulmonary JJ cord-016990-ot1wi3xi 851 13 syndrome syndrome NN cord-016990-ot1wi3xi 851 14 Distinction Distinction NNP cord-016990-ot1wi3xi 851 15 between between IN cord-016990-ot1wi3xi 851 16 Bunyaviridae Bunyaviridae NNP cord-016990-ot1wi3xi 851 17 genera genus NNS cord-016990-ot1wi3xi 851 18 by by IN cord-016990-ot1wi3xi 851 19 surface surface NN cord-016990-ot1wi3xi 851 20 structure structure NN cord-016990-ot1wi3xi 851 21 and and CC cord-016990-ot1wi3xi 851 22 comparison comparison NN cord-016990-ot1wi3xi 851 23 with with IN cord-016990-ot1wi3xi 851 24 Hantaan Hantaan NNP cord-016990-ot1wi3xi 851 25 virus virus NN cord-016990-ot1wi3xi 851 26 using use VBG cord-016990-ot1wi3xi 851 27 negative negative JJ cord-016990-ot1wi3xi 851 28 stain stain NN cord-016990-ot1wi3xi 851 29 electron electron NN cord-016990-ot1wi3xi 851 30 microscopy microscopy NN cord-016990-ot1wi3xi 851 31 Isolation isolation NN cord-016990-ot1wi3xi 851 32 of of IN cord-016990-ot1wi3xi 851 33 the the DT cord-016990-ot1wi3xi 851 34 causative causative JJ cord-016990-ot1wi3xi 851 35 agent agent NN cord-016990-ot1wi3xi 851 36 of of IN cord-016990-ot1wi3xi 851 37 hantavirus hantavirus NNP cord-016990-ot1wi3xi 851 38 pulmonary pulmonary JJ cord-016990-ot1wi3xi 851 39 syndrome syndrome NN cord-016990-ot1wi3xi 851 40 Update update NN cord-016990-ot1wi3xi 851 41 : : : cord-016990-ot1wi3xi 851 42 hantavirus hantavirus NN cord-016990-ot1wi3xi 851 43 pulmonary pulmonary JJ cord-016990-ot1wi3xi 851 44 syndrome syndrome NN cord-016990-ot1wi3xi 851 45 - - : cord-016990-ot1wi3xi 851 46 United United NNP cord-016990-ot1wi3xi 851 47 States States NNP cord-016990-ot1wi3xi 851 48 World World NNP cord-016990-ot1wi3xi 851 49 Health Health NNP cord-016990-ot1wi3xi 851 50 Organization Organization NNP cord-016990-ot1wi3xi 851 51 ( ( -LRB- cord-016990-ot1wi3xi 851 52 WHO who WP cord-016990-ot1wi3xi 851 53 ) ) -RRB- cord-016990-ot1wi3xi 851 54 collaborating collaborate VBG cord-016990-ot1wi3xi 851 55 center center NN cord-016990-ot1wi3xi 851 56 for for IN cord-016990-ot1wi3xi 851 57 virus virus NN cord-016990-ot1wi3xi 851 58 reference reference NN cord-016990-ot1wi3xi 851 59 and and CC cord-016990-ot1wi3xi 851 60 research research NN cord-016990-ot1wi3xi 851 61 Hantavirus Hantavirus NNP cord-016990-ot1wi3xi 851 62 pulmonary pulmonary JJ cord-016990-ot1wi3xi 851 63 syndrome syndrome NN cord-016990-ot1wi3xi 851 64 : : : cord-016990-ot1wi3xi 851 65 a a DT cord-016990-ot1wi3xi 851 66 clinical clinical JJ cord-016990-ot1wi3xi 851 67 description description NN cord-016990-ot1wi3xi 851 68 of of IN cord-016990-ot1wi3xi 851 69 17 17 CD cord-016990-ot1wi3xi 851 70 patients patient NNS cord-016990-ot1wi3xi 851 71 with with IN cord-016990-ot1wi3xi 851 72 a a DT cord-016990-ot1wi3xi 851 73 newly newly RB cord-016990-ot1wi3xi 851 74 recognized recognize VBN cord-016990-ot1wi3xi 851 75 disease disease NN cord-016990-ot1wi3xi 851 76 . . . cord-016990-ot1wi3xi 852 1 The the DT cord-016990-ot1wi3xi 852 2 Hantavirus Hantavirus NNP cord-016990-ot1wi3xi 852 3 Study Study NNP cord-016990-ot1wi3xi 852 4 Group Group NNP cord-016990-ot1wi3xi 852 5 Isolation Isolation NNP cord-016990-ot1wi3xi 852 6 of of IN cord-016990-ot1wi3xi 852 7 the the DT cord-016990-ot1wi3xi 852 8 etiologic etiologic JJ cord-016990-ot1wi3xi 852 9 agent agent NN cord-016990-ot1wi3xi 852 10 of of IN cord-016990-ot1wi3xi 852 11 Korean korean JJ cord-016990-ot1wi3xi 852 12 Hemorrhagic Hemorrhagic NNP cord-016990-ot1wi3xi 852 13 fever fever NN cord-016990-ot1wi3xi 852 14 Centers Centers NNPS cord-016990-ot1wi3xi 852 15 for for IN cord-016990-ot1wi3xi 852 16 Disease Disease NNP cord-016990-ot1wi3xi 852 17 Control Control NNP cord-016990-ot1wi3xi 852 18 and and CC cord-016990-ot1wi3xi 852 19 Prevention Prevention NNP cord-016990-ot1wi3xi 852 20 . . . cord-016990-ot1wi3xi 853 1 Outbreak outbreak NN cord-016990-ot1wi3xi 853 2 of of IN cord-016990-ot1wi3xi 853 3 acute acute JJ cord-016990-ot1wi3xi 853 4 illness illness NN cord-016990-ot1wi3xi 853 5 - - HYPH cord-016990-ot1wi3xi 853 6 southwestern southwestern JJ cord-016990-ot1wi3xi 853 7 United United NNP cord-016990-ot1wi3xi 853 8 States States NNP cord-016990-ot1wi3xi 853 9 Hantavirus Hantavirus NNP cord-016990-ot1wi3xi 853 10 pulmonary pulmonary JJ cord-016990-ot1wi3xi 853 11 syndrome syndrome NN cord-016990-ot1wi3xi 853 12 . . . cord-016990-ot1wi3xi 854 1 Pathogenesis pathogenesis NN cord-016990-ot1wi3xi 854 2 of of IN cord-016990-ot1wi3xi 854 3 an an DT cord-016990-ot1wi3xi 854 4 emerging emerge VBG cord-016990-ot1wi3xi 854 5 infectious infectious JJ cord-016990-ot1wi3xi 854 6 disease disease NN cord-016990-ot1wi3xi 854 7 Hantavirus Hantavirus NNP cord-016990-ot1wi3xi 854 8 - - HYPH cord-016990-ot1wi3xi 854 9 associated associate VBN cord-016990-ot1wi3xi 854 10 diseases disease NNS cord-016990-ot1wi3xi 855 1 Hantavirus Hantavirus NNP cord-016990-ot1wi3xi 855 2 pulmonary pulmonary JJ cord-016990-ot1wi3xi 855 3 syndrome syndrome NN cord-016990-ot1wi3xi 855 4 in in IN cord-016990-ot1wi3xi 855 5 the the DT cord-016990-ot1wi3xi 855 6 United United NNP cord-016990-ot1wi3xi 855 7 States States NNP cord-016990-ot1wi3xi 855 8 : : : cord-016990-ot1wi3xi 855 9 a a DT cord-016990-ot1wi3xi 855 10 pathological pathological JJ cord-016990-ot1wi3xi 855 11 description description NN cord-016990-ot1wi3xi 855 12 of of IN cord-016990-ot1wi3xi 855 13 a a DT cord-016990-ot1wi3xi 855 14 disease disease NN cord-016990-ot1wi3xi 855 15 caused cause VBN cord-016990-ot1wi3xi 855 16 by by IN cord-016990-ot1wi3xi 855 17 a a DT cord-016990-ot1wi3xi 855 18 new new JJ cord-016990-ot1wi3xi 855 19 agent agent NN cord-016990-ot1wi3xi 856 1 The the DT cord-016990-ot1wi3xi 856 2 pathology pathology NN cord-016990-ot1wi3xi 856 3 of of IN cord-016990-ot1wi3xi 856 4 thirty thirty CD cord-016990-ot1wi3xi 856 5 - - HYPH cord-016990-ot1wi3xi 856 6 nine nine CD cord-016990-ot1wi3xi 856 7 fatal fatal JJ cord-016990-ot1wi3xi 856 8 cases case NNS cord-016990-ot1wi3xi 856 9 of of IN cord-016990-ot1wi3xi 856 10 epidemic epidemic JJ cord-016990-ot1wi3xi 856 11 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 856 12 fever fever NN cord-016990-ot1wi3xi 856 13 Pathology pathology NN cord-016990-ot1wi3xi 856 14 of of IN cord-016990-ot1wi3xi 856 15 epidemic epidemic JJ cord-016990-ot1wi3xi 856 16 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 856 17 fever fever NN cord-016990-ot1wi3xi 856 18 Kessler Kessler NNP cord-016990-ot1wi3xi 856 19 WHo who WP cord-016990-ot1wi3xi 857 1 Gross gross JJ cord-016990-ot1wi3xi 857 2 anatomic anatomic JJ cord-016990-ot1wi3xi 857 3 features feature NNS cord-016990-ot1wi3xi 857 4 found find VBN cord-016990-ot1wi3xi 857 5 in in IN cord-016990-ot1wi3xi 857 6 27 27 CD cord-016990-ot1wi3xi 857 7 autopsies autopsy NNS cord-016990-ot1wi3xi 857 8 of of IN cord-016990-ot1wi3xi 857 9 epidemic epidemic JJ cord-016990-ot1wi3xi 857 10 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 857 11 fever fever NN cord-016990-ot1wi3xi 857 12 Pathology pathology NN cord-016990-ot1wi3xi 857 13 of of IN cord-016990-ot1wi3xi 857 14 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 857 15 fever fever NN cord-016990-ot1wi3xi 857 16 : : : cord-016990-ot1wi3xi 857 17 a a DT cord-016990-ot1wi3xi 857 18 comparison comparison NN cord-016990-ot1wi3xi 857 19 of of IN cord-016990-ot1wi3xi 857 20 the the DT cord-016990-ot1wi3xi 857 21 findings finding NNS cord-016990-ot1wi3xi 857 22 , , , cord-016990-ot1wi3xi 857 23 1951 1951 CD cord-016990-ot1wi3xi 857 24 and and CC cord-016990-ot1wi3xi 857 25 1952 1952 CD cord-016990-ot1wi3xi 857 26 Identification identification NN cord-016990-ot1wi3xi 857 27 of of IN cord-016990-ot1wi3xi 857 28 Hantaan Hantaan NNP cord-016990-ot1wi3xi 857 29 virus virus NN cord-016990-ot1wi3xi 857 30 - - HYPH cord-016990-ot1wi3xi 857 31 related relate VBN cord-016990-ot1wi3xi 857 32 structures structure NNS cord-016990-ot1wi3xi 857 33 in in IN cord-016990-ot1wi3xi 857 34 kidneys kidney NNS cord-016990-ot1wi3xi 857 35 of of IN cord-016990-ot1wi3xi 857 36 cadavers cadaver NNS cord-016990-ot1wi3xi 857 37 with with IN cord-016990-ot1wi3xi 857 38 haemorrhagic haemorrhagic JJ cord-016990-ot1wi3xi 857 39 fever fever NN cord-016990-ot1wi3xi 857 40 with with IN cord-016990-ot1wi3xi 857 41 renal renal JJ cord-016990-ot1wi3xi 857 42 syndrome syndrome NN cord-016990-ot1wi3xi 858 1 An an DT cord-016990-ot1wi3xi 858 2 autopsy autopsy JJ cord-016990-ot1wi3xi 858 3 case case NN cord-016990-ot1wi3xi 858 4 of of IN cord-016990-ot1wi3xi 858 5 epidemic epidemic JJ cord-016990-ot1wi3xi 858 6 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 858 7 fever fever NN cord-016990-ot1wi3xi 858 8 ( ( -LRB- cord-016990-ot1wi3xi 858 9 Korean korean JJ cord-016990-ot1wi3xi 858 10 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 858 11 fever fever NN cord-016990-ot1wi3xi 858 12 ) ) -RRB- cord-016990-ot1wi3xi 859 1 Baculovirus Baculovirus NNP cord-016990-ot1wi3xi 859 2 expression expression NN cord-016990-ot1wi3xi 859 3 of of IN cord-016990-ot1wi3xi 859 4 the the DT cord-016990-ot1wi3xi 859 5 small small JJ cord-016990-ot1wi3xi 859 6 genome genome NN cord-016990-ot1wi3xi 859 7 segment segment NN cord-016990-ot1wi3xi 859 8 of of IN cord-016990-ot1wi3xi 859 9 Hantaan Hantaan NNP cord-016990-ot1wi3xi 859 10 virus virus NN cord-016990-ot1wi3xi 859 11 and and CC cord-016990-ot1wi3xi 859 12 potential potential JJ cord-016990-ot1wi3xi 859 13 use use NN cord-016990-ot1wi3xi 859 14 of of IN cord-016990-ot1wi3xi 859 15 the the DT cord-016990-ot1wi3xi 859 16 expressed express VBN cord-016990-ot1wi3xi 859 17 nucleocapsid nucleocapsid NN cord-016990-ot1wi3xi 859 18 protein protein NN cord-016990-ot1wi3xi 859 19 as as IN cord-016990-ot1wi3xi 859 20 a a DT cord-016990-ot1wi3xi 859 21 diagnostic diagnostic JJ cord-016990-ot1wi3xi 859 22 antigen antigen NN cord-016990-ot1wi3xi 859 23 Utilization utilization NN cord-016990-ot1wi3xi 859 24 of of IN cord-016990-ot1wi3xi 859 25 autopsy autopsy JJ cord-016990-ot1wi3xi 859 26 RNA RNA NNP cord-016990-ot1wi3xi 859 27 for for IN cord-016990-ot1wi3xi 859 28 the the DT cord-016990-ot1wi3xi 859 29 synthesis synthesis NN cord-016990-ot1wi3xi 859 30 of of IN cord-016990-ot1wi3xi 859 31 the the DT cord-016990-ot1wi3xi 859 32 nucleocapsid nucleocapsid NNP cord-016990-ot1wi3xi 859 33 antigen antigen NNP cord-016990-ot1wi3xi 859 34 of of IN cord-016990-ot1wi3xi 859 35 a a DT cord-016990-ot1wi3xi 859 36 newly newly RB cord-016990-ot1wi3xi 859 37 recognized recognize VBN cord-016990-ot1wi3xi 859 38 virus virus NN cord-016990-ot1wi3xi 859 39 associated associate VBN cord-016990-ot1wi3xi 859 40 with with IN cord-016990-ot1wi3xi 859 41 hantavirus hantavirus NN cord-016990-ot1wi3xi 859 42 pulmonary pulmonary JJ cord-016990-ot1wi3xi 859 43 syndrome syndrome NN cord-016990-ot1wi3xi 859 44 Detection detection NN cord-016990-ot1wi3xi 859 45 and and CC cord-016990-ot1wi3xi 859 46 sequence sequence NN cord-016990-ot1wi3xi 859 47 confirmation confirmation NN cord-016990-ot1wi3xi 859 48 of of IN cord-016990-ot1wi3xi 859 49 Sin Sin NNP cord-016990-ot1wi3xi 859 50 Nombre Nombre NNP cord-016990-ot1wi3xi 859 51 virus virus NN cord-016990-ot1wi3xi 859 52 RNA RNA NNP cord-016990-ot1wi3xi 859 53 in in IN cord-016990-ot1wi3xi 859 54 paraffin paraffin NN cord-016990-ot1wi3xi 859 55 - - HYPH cord-016990-ot1wi3xi 859 56 embedded embed VBN cord-016990-ot1wi3xi 859 57 human human JJ cord-016990-ot1wi3xi 859 58 tissues tissue NNS cord-016990-ot1wi3xi 859 59 using use VBG cord-016990-ot1wi3xi 859 60 one one CD cord-016990-ot1wi3xi 859 61 - - HYPH cord-016990-ot1wi3xi 859 62 step step NN cord-016990-ot1wi3xi 859 63 RT RT NNP cord-016990-ot1wi3xi 859 64 - - HYPH cord-016990-ot1wi3xi 859 65 PCR PCR NNP cord-016990-ot1wi3xi 859 66 Retrospective retrospective JJ cord-016990-ot1wi3xi 859 67 diagnosis diagnosis NN cord-016990-ot1wi3xi 859 68 of of IN cord-016990-ot1wi3xi 859 69 hantavirus hantavirus NN cord-016990-ot1wi3xi 859 70 pulmonary pulmonary JJ cord-016990-ot1wi3xi 859 71 syndrome syndrome NN cord-016990-ot1wi3xi 859 72 , , , cord-016990-ot1wi3xi 859 73 1978 1978 CD cord-016990-ot1wi3xi 859 74 - - SYM cord-016990-ot1wi3xi 859 75 1993 1993 CD cord-016990-ot1wi3xi 859 76 : : : cord-016990-ot1wi3xi 859 77 implications implication NNS cord-016990-ot1wi3xi 859 78 for for IN cord-016990-ot1wi3xi 859 79 emerging emerge VBG cord-016990-ot1wi3xi 859 80 infectious infectious JJ cord-016990-ot1wi3xi 859 81 diseases disease NNS cord-016990-ot1wi3xi 859 82 Retrospective retrospective JJ cord-016990-ot1wi3xi 859 83 diagnosis diagnosis NN cord-016990-ot1wi3xi 859 84 of of IN cord-016990-ot1wi3xi 859 85 a a DT cord-016990-ot1wi3xi 859 86 1983 1983 CD cord-016990-ot1wi3xi 859 87 case case NN cord-016990-ot1wi3xi 859 88 of of IN cord-016990-ot1wi3xi 859 89 fatal fatal JJ cord-016990-ot1wi3xi 859 90 hantavirus hantavirus NN cord-016990-ot1wi3xi 859 91 pulmonary pulmonary JJ cord-016990-ot1wi3xi 859 92 syndrome syndrome NN cord-016990-ot1wi3xi 859 93 Ultrastructural ultrastructural JJ cord-016990-ot1wi3xi 859 94 characterization characterization NN cord-016990-ot1wi3xi 859 95 of of IN cord-016990-ot1wi3xi 859 96 SARS SARS NNP cord-016990-ot1wi3xi 859 97 coronavirus coronavirus NN cord-016990-ot1wi3xi 859 98 Proliferative Proliferative NNP cord-016990-ot1wi3xi 859 99 growth growth NN cord-016990-ot1wi3xi 859 100 of of IN cord-016990-ot1wi3xi 859 101 SARS SARS NNP cord-016990-ot1wi3xi 859 102 corona corona NNP cord-016990-ot1wi3xi 859 103 virus virus NN cord-016990-ot1wi3xi 859 104 in in IN cord-016990-ot1wi3xi 859 105 Vero Vero NNP cord-016990-ot1wi3xi 859 106 E6 E6 NNP cord-016990-ot1wi3xi 859 107 cells cell NNS cord-016990-ot1wi3xi 859 108 Morphogenesis Morphogenesis NNP cord-016990-ot1wi3xi 859 109 of of IN cord-016990-ot1wi3xi 859 110 avian avian JJ cord-016990-ot1wi3xi 859 111 infectious infectious JJ cord-016990-ot1wi3xi 859 112 bronchitis bronchitis NN cord-016990-ot1wi3xi 859 113 virus virus NN cord-016990-ot1wi3xi 859 114 and and CC cord-016990-ot1wi3xi 859 115 a a DT cord-016990-ot1wi3xi 859 116 related relate VBN cord-016990-ot1wi3xi 859 117 human human JJ cord-016990-ot1wi3xi 859 118 virus virus NN cord-016990-ot1wi3xi 859 119 ( ( -LRB- cord-016990-ot1wi3xi 859 120 strain strain NN cord-016990-ot1wi3xi 859 121 229E 229e CD cord-016990-ot1wi3xi 859 122 ) ) -RRB- cord-016990-ot1wi3xi 860 1 Assembly Assembly NNP cord-016990-ot1wi3xi 860 2 of of IN cord-016990-ot1wi3xi 860 3 enveloped envelop VBN cord-016990-ot1wi3xi 860 4 RNA RNA NNP cord-016990-ot1wi3xi 860 5 viruses virus NNS cord-016990-ot1wi3xi 860 6 Electron Electron NNP cord-016990-ot1wi3xi 860 7 microscopic microscopic JJ cord-016990-ot1wi3xi 860 8 studies study NNS cord-016990-ot1wi3xi 860 9 of of IN cord-016990-ot1wi3xi 860 10 coronavirus coronavirus NN cord-016990-ot1wi3xi 860 11 Coronavirus Coronavirus NNP cord-016990-ot1wi3xi 860 12 as as IN cord-016990-ot1wi3xi 860 13 a a DT cord-016990-ot1wi3xi 860 14 possible possible JJ cord-016990-ot1wi3xi 860 15 cause cause NN cord-016990-ot1wi3xi 860 16 of of IN cord-016990-ot1wi3xi 860 17 severe severe JJ cord-016990-ot1wi3xi 860 18 acute acute JJ cord-016990-ot1wi3xi 860 19 respiratory respiratory JJ cord-016990-ot1wi3xi 860 20 syndrome syndrome NN cord-016990-ot1wi3xi 860 21 Analysis analysis NN cord-016990-ot1wi3xi 860 22 of of IN cord-016990-ot1wi3xi 860 23 deaths death NNS cord-016990-ot1wi3xi 860 24 during during IN cord-016990-ot1wi3xi 860 25 the the DT cord-016990-ot1wi3xi 860 26 severe severe JJ cord-016990-ot1wi3xi 860 27 acute acute JJ cord-016990-ot1wi3xi 860 28 respiratory respiratory JJ cord-016990-ot1wi3xi 860 29 syndrome syndrome NN cord-016990-ot1wi3xi 860 30 ( ( -LRB- cord-016990-ot1wi3xi 860 31 SARS SARS NNP cord-016990-ot1wi3xi 860 32 ) ) -RRB- cord-016990-ot1wi3xi 860 33 epidemic epidemic NN cord-016990-ot1wi3xi 860 34 in in IN cord-016990-ot1wi3xi 860 35 Singapore Singapore NNP cord-016990-ot1wi3xi 860 36 : : : cord-016990-ot1wi3xi 860 37 challenges challenge NNS cord-016990-ot1wi3xi 860 38 in in IN cord-016990-ot1wi3xi 860 39 determining determine VBG cord-016990-ot1wi3xi 860 40 a a DT cord-016990-ot1wi3xi 860 41 SARS SARS NNP cord-016990-ot1wi3xi 860 42 diagnosis diagnosis NN cord-016990-ot1wi3xi 861 1 The the DT cord-016990-ot1wi3xi 861 2 clinical clinical JJ cord-016990-ot1wi3xi 861 3 pathology pathology NN cord-016990-ot1wi3xi 861 4 of of IN cord-016990-ot1wi3xi 861 5 severe severe JJ cord-016990-ot1wi3xi 861 6 acute acute JJ cord-016990-ot1wi3xi 861 7 respiratory respiratory JJ cord-016990-ot1wi3xi 861 8 syndrome syndrome NN cord-016990-ot1wi3xi 861 9 ( ( -LRB- cord-016990-ot1wi3xi 861 10 SARS SARS NNP cord-016990-ot1wi3xi 861 11 ) ) -RRB- cord-016990-ot1wi3xi 861 12 : : : cord-016990-ot1wi3xi 862 1 a a DT cord-016990-ot1wi3xi 862 2 report report NN cord-016990-ot1wi3xi 862 3 from from IN cord-016990-ot1wi3xi 862 4 China China NNP cord-016990-ot1wi3xi 862 5 Lung Lung NNP cord-016990-ot1wi3xi 862 6 pathology pathology NN cord-016990-ot1wi3xi 862 7 of of IN cord-016990-ot1wi3xi 862 8 severe severe JJ cord-016990-ot1wi3xi 862 9 acute acute JJ cord-016990-ot1wi3xi 862 10 respiratory respiratory JJ cord-016990-ot1wi3xi 862 11 syndrome syndrome NN cord-016990-ot1wi3xi 862 12 ( ( -LRB- cord-016990-ot1wi3xi 862 13 SARS SARS NNP cord-016990-ot1wi3xi 862 14 ) ) -RRB- cord-016990-ot1wi3xi 862 15 : : : cord-016990-ot1wi3xi 862 16 a a DT cord-016990-ot1wi3xi 862 17 study study NN cord-016990-ot1wi3xi 862 18 of of IN cord-016990-ot1wi3xi 862 19 8 8 CD cord-016990-ot1wi3xi 862 20 autopsy autopsy JJ cord-016990-ot1wi3xi 862 21 cases case NNS cord-016990-ot1wi3xi 862 22 from from IN cord-016990-ot1wi3xi 862 23 Singapore Singapore NNP cord-016990-ot1wi3xi 862 24 A A NNP cord-016990-ot1wi3xi 862 25 clinicopathological clinicopathological JJ cord-016990-ot1wi3xi 862 26 study study NN cord-016990-ot1wi3xi 862 27 on on IN cord-016990-ot1wi3xi 862 28 3 3 CD cord-016990-ot1wi3xi 862 29 cases case NNS cord-016990-ot1wi3xi 862 30 of of IN cord-016990-ot1wi3xi 862 31 severe severe JJ cord-016990-ot1wi3xi 862 32 acute acute JJ cord-016990-ot1wi3xi 862 33 respiratory respiratory JJ cord-016990-ot1wi3xi 862 34 syndrome syndrome NN cord-016990-ot1wi3xi 862 35 Enteric enteric JJ cord-016990-ot1wi3xi 862 36 involvement involvement NN cord-016990-ot1wi3xi 862 37 of of IN cord-016990-ot1wi3xi 862 38 severe severe JJ cord-016990-ot1wi3xi 862 39 acute acute JJ cord-016990-ot1wi3xi 862 40 respiratory respiratory JJ cord-016990-ot1wi3xi 862 41 syndrome syndrome NN cord-016990-ot1wi3xi 862 42 - - HYPH cord-016990-ot1wi3xi 862 43 associated associate VBN cord-016990-ot1wi3xi 862 44 coronavirus coronavirus NN cord-016990-ot1wi3xi 862 45 infection infection NN cord-016990-ot1wi3xi 862 46 Lung Lung NNP cord-016990-ot1wi3xi 862 47 pathology pathology NN cord-016990-ot1wi3xi 862 48 of of IN cord-016990-ot1wi3xi 862 49 fatal fatal JJ cord-016990-ot1wi3xi 862 50 severe severe JJ cord-016990-ot1wi3xi 862 51 acute acute JJ cord-016990-ot1wi3xi 862 52 respiratory respiratory JJ cord-016990-ot1wi3xi 862 53 syndrome syndrome NN cord-016990-ot1wi3xi 862 54 Butany Butany NNP cord-016990-ot1wi3xi 862 55 1 1 CD cord-016990-ot1wi3xi 862 56 . . . cord-016990-ot1wi3xi 863 1 Pulmonary pulmonary JJ cord-016990-ot1wi3xi 863 2 pathology pathology NN cord-016990-ot1wi3xi 863 3 of of IN cord-016990-ot1wi3xi 863 4 severe severe JJ cord-016990-ot1wi3xi 863 5 acute acute JJ cord-016990-ot1wi3xi 863 6 respiratory respiratory JJ cord-016990-ot1wi3xi 863 7 syndrome syndrome NN cord-016990-ot1wi3xi 863 8 in in IN cord-016990-ot1wi3xi 863 9 Toronto Toronto NNP cord-016990-ot1wi3xi 863 10 SARS SARS NNP cord-016990-ot1wi3xi 863 11 coronavirus coronavirus NN cord-016990-ot1wi3xi 863 12 - - HYPH cord-016990-ot1wi3xi 863 13 infected infect VBN cord-016990-ot1wi3xi 863 14 cells cell NNS cord-016990-ot1wi3xi 863 15 in in IN cord-016990-ot1wi3xi 863 16 lung lung NN cord-016990-ot1wi3xi 863 17 detected detect VBN cord-016990-ot1wi3xi 863 18 by by IN cord-016990-ot1wi3xi 863 19 new new JJ cord-016990-ot1wi3xi 863 20 in in IN cord-016990-ot1wi3xi 863 21 situ situ JJ cord-016990-ot1wi3xi 863 22 hybridization hybridization NN cord-016990-ot1wi3xi 863 23 technique technique NN cord-016990-ot1wi3xi 863 24 Immunohistochemical Immunohistochemical NNP cord-016990-ot1wi3xi 863 25 , , , cord-016990-ot1wi3xi 863 26 in in IN cord-016990-ot1wi3xi 863 27 situ situ NN cord-016990-ot1wi3xi 863 28 hybridization hybridization NN cord-016990-ot1wi3xi 863 29 , , , cord-016990-ot1wi3xi 863 30 and and CC cord-016990-ot1wi3xi 863 31 ultrastructurallocalization ultrastructurallocalization NN cord-016990-ot1wi3xi 863 32 of of IN cord-016990-ot1wi3xi 863 33 SARS SARS NNP cord-016990-ot1wi3xi 863 34 - - HYPH cord-016990-ot1wi3xi 863 35 associated associate VBN cord-016990-ot1wi3xi 863 36 coronavirus coronavirus NN cord-016990-ot1wi3xi 863 37 in in IN cord-016990-ot1wi3xi 863 38 lung lung NN cord-016990-ot1wi3xi 863 39 of of IN cord-016990-ot1wi3xi 863 40 a a DT cord-016990-ot1wi3xi 863 41 fatal fatal JJ cord-016990-ot1wi3xi 863 42 case case NN cord-016990-ot1wi3xi 863 43 of of IN cord-016990-ot1wi3xi 863 44 severe severe JJ cord-016990-ot1wi3xi 863 45 acute acute JJ cord-016990-ot1wi3xi 863 46 respiratory respiratory JJ cord-016990-ot1wi3xi 863 47 syndrome syndrome NN cord-016990-ot1wi3xi 863 48 in in IN cord-016990-ot1wi3xi 863 49 Taiwan Taiwan NNP cord-016990-ot1wi3xi 863 50 Tissue Tissue NNP cord-016990-ot1wi3xi 863 51 and and CC cord-016990-ot1wi3xi 863 52 cellular cellular JJ cord-016990-ot1wi3xi 863 53 tropism tropism NN cord-016990-ot1wi3xi 863 54 of of IN cord-016990-ot1wi3xi 863 55 the the DT cord-016990-ot1wi3xi 863 56 coronavirus coronavirus NN cord-016990-ot1wi3xi 863 57 associated associate VBN cord-016990-ot1wi3xi 863 58 with with IN cord-016990-ot1wi3xi 863 59 severe severe JJ cord-016990-ot1wi3xi 863 60 acute acute JJ cord-016990-ot1wi3xi 863 61 respiratory respiratory JJ cord-016990-ot1wi3xi 863 62 syndrome syndrome NN cord-016990-ot1wi3xi 863 63 : : : cord-016990-ot1wi3xi 863 64 an an DT cord-016990-ot1wi3xi 863 65 in in IN cord-016990-ot1wi3xi 863 66 - - HYPH cord-016990-ot1wi3xi 863 67 situ situ NN cord-016990-ot1wi3xi 863 68 hybridization hybridization NN cord-016990-ot1wi3xi 863 69 study study NN cord-016990-ot1wi3xi 863 70 of of IN cord-016990-ot1wi3xi 863 71 fatal fatal JJ cord-016990-ot1wi3xi 863 72 cases case NNS cord-016990-ot1wi3xi 863 73 Acute acute JJ cord-016990-ot1wi3xi 863 74 lung lung NN cord-016990-ot1wi3xi 863 75 injury injury NN cord-016990-ot1wi3xi 863 76 patterns pattern NNS cord-016990-ot1wi3xi 863 77 : : : cord-016990-ot1wi3xi 863 78 diffuse diffuse VB cord-016990-ot1wi3xi 863 79 alveolar alveolar JJ cord-016990-ot1wi3xi 863 80 damage damage NN cord-016990-ot1wi3xi 863 81 and and CC cord-016990-ot1wi3xi 863 82 bronchiolitis bronchiolitis NN cord-016990-ot1wi3xi 863 83 obliterans obliterans NN cord-016990-ot1wi3xi 863 84 - - HYPH cord-016990-ot1wi3xi 863 85 organizing organize VBG cord-016990-ot1wi3xi 863 86 pneumonia pneumonia NN cord-016990-ot1wi3xi 863 87 Pathology Pathology NNP cord-016990-ot1wi3xi 863 88 of of IN cord-016990-ot1wi3xi 863 89 infectious infectious JJ cord-016990-ot1wi3xi 863 90 diseases disease NNS cord-016990-ot1wi3xi 864 1 Nipah Nipah NNP cord-016990-ot1wi3xi 864 2 virus virus NN cord-016990-ot1wi3xi 864 3 infection infection NN cord-016990-ot1wi3xi 864 4 : : : cord-016990-ot1wi3xi 864 5 pathology pathology NN cord-016990-ot1wi3xi 864 6 and and CC cord-016990-ot1wi3xi 864 7 pathogenesis pathogenesis NN cord-016990-ot1wi3xi 864 8 of of IN cord-016990-ot1wi3xi 864 9 an an DT cord-016990-ot1wi3xi 864 10 emerging emerge VBG cord-016990-ot1wi3xi 864 11 paramyxoviral paramyxoviral JJ cord-016990-ot1wi3xi 864 12 zoonosis zoonosis NN cord-016990-ot1wi3xi 864 13 Immunohistochemical Immunohistochemical NNP cord-016990-ot1wi3xi 864 14 and and CC cord-016990-ot1wi3xi 864 15 in in IN cord-016990-ot1wi3xi 864 16 situ situ JJ cord-016990-ot1wi3xi 864 17 hybridization hybridization NN cord-016990-ot1wi3xi 864 18 studies study NNS cord-016990-ot1wi3xi 864 19 of of IN cord-016990-ot1wi3xi 864 20 influenza influenza NN cord-016990-ot1wi3xi 864 21 A a DT cord-016990-ot1wi3xi 864 22 virus virus NN cord-016990-ot1wi3xi 864 23 infection infection NN cord-016990-ot1wi3xi 864 24 in in IN cord-016990-ot1wi3xi 864 25 human human JJ cord-016990-ot1wi3xi 864 26 lungs lung NNS cord-016990-ot1wi3xi 864 27 Newly newly RB cord-016990-ot1wi3xi 864 28 discovered discover VBN cord-016990-ot1wi3xi 864 29 coronavirus coronavirus NN cord-016990-ot1wi3xi 864 30 as as IN cord-016990-ot1wi3xi 864 31 the the DT cord-016990-ot1wi3xi 864 32 primary primary JJ cord-016990-ot1wi3xi 864 33 cause cause NN cord-016990-ot1wi3xi 864 34 of of IN cord-016990-ot1wi3xi 864 35 severe severe JJ cord-016990-ot1wi3xi 864 36 acute acute JJ cord-016990-ot1wi3xi 864 37 respiratory respiratory JJ cord-016990-ot1wi3xi 864 38 syndrome syndrome NN cord-016990-ot1wi3xi 865 1 Pegylated pegylate VBN cord-016990-ot1wi3xi 866 1 interferon interferon NN cord-016990-ot1wi3xi 866 2 - - HYPH cord-016990-ot1wi3xi 866 3 alpha alpha NN cord-016990-ot1wi3xi 866 4 protects protect VBZ cord-016990-ot1wi3xi 866 5 type type NN cord-016990-ot1wi3xi 866 6 1 1 CD cord-016990-ot1wi3xi 866 7 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 866 8 against against IN cord-016990-ot1wi3xi 866 9 SARS SARS NNP cord-016990-ot1wi3xi 866 10 coronavirus coronavirus NN cord-016990-ot1wi3xi 866 11 infection infection NN cord-016990-ot1wi3xi 866 12 in in IN cord-016990-ot1wi3xi 866 13 macaques macaque NNS cord-016990-ot1wi3xi 866 14 Replication Replication NNP cord-016990-ot1wi3xi 866 15 of of IN cord-016990-ot1wi3xi 866 16 SARS SARS NNP cord-016990-ot1wi3xi 866 17 corona corona NNP cord-016990-ot1wi3xi 866 18 virus virus NN cord-016990-ot1wi3xi 866 19 administered administer VBN cord-016990-ot1wi3xi 866 20 into into IN cord-016990-ot1wi3xi 866 21 the the DT cord-016990-ot1wi3xi 866 22 respiratory respiratory JJ cord-016990-ot1wi3xi 866 23 tract tract NN cord-016990-ot1wi3xi 866 24 of of IN cord-016990-ot1wi3xi 866 25 African African NNP cord-016990-ot1wi3xi 866 26 Green Green NNP cord-016990-ot1wi3xi 866 27 , , , cord-016990-ot1wi3xi 866 28 rhesus rhesu NNS cord-016990-ot1wi3xi 866 29 and and CC cord-016990-ot1wi3xi 866 30 cynomolgus cynomolgus JJ cord-016990-ot1wi3xi 866 31 monkeys monkey NNS cord-016990-ot1wi3xi 867 1 Prior prior JJ cord-016990-ot1wi3xi 867 2 infection infection NN cord-016990-ot1wi3xi 867 3 and and CC cord-016990-ot1wi3xi 867 4 passive passive JJ cord-016990-ot1wi3xi 867 5 transfer transfer NN cord-016990-ot1wi3xi 867 6 of of IN cord-016990-ot1wi3xi 867 7 neutralizing neutralize VBG cord-016990-ot1wi3xi 867 8 antibody antibody NN cord-016990-ot1wi3xi 867 9 prevent prevent VB cord-016990-ot1wi3xi 867 10 replication replication NN cord-016990-ot1wi3xi 867 11 of of IN cord-016990-ot1wi3xi 867 12 severe severe JJ cord-016990-ot1wi3xi 867 13 acute acute JJ cord-016990-ot1wi3xi 867 14 respiratory respiratory JJ cord-016990-ot1wi3xi 867 15 syndrome syndrome NN cord-016990-ot1wi3xi 867 16 coronavirus coronavirus NN cord-016990-ot1wi3xi 867 17 in in IN cord-016990-ot1wi3xi 867 18 the the DT cord-016990-ot1wi3xi 867 19 respiratory respiratory JJ cord-016990-ot1wi3xi 867 20 tract tract NN cord-016990-ot1wi3xi 867 21 of of IN cord-016990-ot1wi3xi 867 22 mice mouse NNS cord-016990-ot1wi3xi 867 23 Severe severe JJ cord-016990-ot1wi3xi 867 24 acute acute JJ cord-016990-ot1wi3xi 867 25 respiratory respiratory JJ cord-016990-ot1wi3xi 867 26 syndrome syndrome NN cord-016990-ot1wi3xi 867 27 corona corona NN cord-016990-ot1wi3xi 867 28 virus virus NN cord-016990-ot1wi3xi 867 29 infection infection NN cord-016990-ot1wi3xi 867 30 of of IN cord-016990-ot1wi3xi 867 31 golden golden JJ cord-016990-ot1wi3xi 867 32 Syrian syrian JJ cord-016990-ot1wi3xi 867 33 hamsters hamster NNS cord-016990-ot1wi3xi 867 34 Uber Uber NNP cord-016990-ot1wi3xi 867 35 protozoenartige protozoenartige NN cord-016990-ot1wi3xi 867 36 Zellen Zellen NNP cord-016990-ot1wi3xi 867 37 in in IN cord-016990-ot1wi3xi 867 38 der der NNP cord-016990-ot1wi3xi 867 39 Niere Niere NNP cord-016990-ot1wi3xi 867 40 eines eines NNP cord-016990-ot1wi3xi 868 1 syphilitischen syphilitischen NNP cord-016990-ot1wi3xi 868 2 Neugoborenen Neugoborenen NNP cord-016990-ot1wi3xi 868 3 und und IN cord-016990-ot1wi3xi 868 4 in in IN cord-016990-ot1wi3xi 868 5 der der NNP cord-016990-ot1wi3xi 868 6 Parotis Parotis NNP cord-016990-ot1wi3xi 868 7 von von NNP cord-016990-ot1wi3xi 868 8 Kindern Kindern NNP cord-016990-ot1wi3xi 869 1 Concerning concern VBG cord-016990-ot1wi3xi 869 2 the the DT cord-016990-ot1wi3xi 869 3 nature nature NN cord-016990-ot1wi3xi 869 4 of of IN cord-016990-ot1wi3xi 869 5 " " `` cord-016990-ot1wi3xi 869 6 protozoan protozoan NN cord-016990-ot1wi3xi 869 7 - - HYPH cord-016990-ot1wi3xi 869 8 like like JJ cord-016990-ot1wi3xi 869 9 " " `` cord-016990-ot1wi3xi 869 10 cells cell NNS cord-016990-ot1wi3xi 869 11 in in IN cord-016990-ot1wi3xi 869 12 certain certain JJ cord-016990-ot1wi3xi 869 13 lesions lesion NNS cord-016990-ot1wi3xi 869 14 of of IN cord-016990-ot1wi3xi 869 15 infancy infancy JJ cord-016990-ot1wi3xi 869 16 Intranuclear Intranuclear NNP cord-016990-ot1wi3xi 869 17 and and CC cord-016990-ot1wi3xi 869 18 cytoplasmic cytoplasmic JJ cord-016990-ot1wi3xi 869 19 inclusions inclusion NNS cord-016990-ot1wi3xi 869 20 ( ( -LRB- cord-016990-ot1wi3xi 869 21 " " `` cord-016990-ot1wi3xi 869 22 protozoan protozoan NN cord-016990-ot1wi3xi 869 23 - - HYPH cord-016990-ot1wi3xi 869 24 like like JJ cord-016990-ot1wi3xi 869 25 bodies body NNS cord-016990-ot1wi3xi 869 26 " " '' cord-016990-ot1wi3xi 869 27 ) ) -RRB- cord-016990-ot1wi3xi 869 28 in in IN cord-016990-ot1wi3xi 869 29 the the DT cord-016990-ot1wi3xi 869 30 salivary salivary NN cord-016990-ot1wi3xi 869 31 glands gland NNS cord-016990-ot1wi3xi 869 32 and and CC cord-016990-ot1wi3xi 869 33 other other JJ cord-016990-ot1wi3xi 869 34 organs organ NNS cord-016990-ot1wi3xi 869 35 of of IN cord-016990-ot1wi3xi 869 36 infants infant NNS cord-016990-ot1wi3xi 869 37 Serologic Serologic NNP cord-016990-ot1wi3xi 869 38 differentiation differentiation NN cord-016990-ot1wi3xi 869 39 of of IN cord-016990-ot1wi3xi 869 40 viruses virus NNS cord-016990-ot1wi3xi 869 41 responsible responsible JJ cord-016990-ot1wi3xi 869 42 for for IN cord-016990-ot1wi3xi 869 43 cytomegalic cytomegalic NNP cord-016990-ot1wi3xi 869 44 inclusion inclusion NN cord-016990-ot1wi3xi 869 45 disease disease NN cord-016990-ot1wi3xi 870 1 Primary primary JJ cord-016990-ot1wi3xi 870 2 chimpanzee chimpanzee NN cord-016990-ot1wi3xi 870 3 skin skin NN cord-016990-ot1wi3xi 870 4 fibroblast fibroblast NN cord-016990-ot1wi3xi 870 5 cells cell NNS cord-016990-ot1wi3xi 870 6 are be VBP cord-016990-ot1wi3xi 870 7 fully fully RB cord-016990-ot1wi3xi 870 8 permissive permissive JJ cord-016990-ot1wi3xi 870 9 for for IN cord-016990-ot1wi3xi 870 10 human human JJ cord-016990-ot1wi3xi 870 11 cytomegalovirus cytomegalovirus NN cord-016990-ot1wi3xi 870 12 replication replication NN cord-016990-ot1wi3xi 870 13 Monocyte Monocyte NNP cord-016990-ot1wi3xi 870 14 - - HYPH cord-016990-ot1wi3xi 870 15 derived derive VBN cord-016990-ot1wi3xi 870 16 dendritic dendritic JJ cord-016990-ot1wi3xi 870 17 cells cell NNS cord-016990-ot1wi3xi 870 18 are be VBP cord-016990-ot1wi3xi 870 19 permissive permissive JJ cord-016990-ot1wi3xi 870 20 to to IN cord-016990-ot1wi3xi 870 21 the the DT cord-016990-ot1wi3xi 870 22 complete complete JJ cord-016990-ot1wi3xi 870 23 replicative replicative JJ cord-016990-ot1wi3xi 870 24 cycle cycle NN cord-016990-ot1wi3xi 870 25 of of IN cord-016990-ot1wi3xi 870 26 human human JJ cord-016990-ot1wi3xi 870 27 cytomegalovirus cytomegalovirus NNP cord-016990-ot1wi3xi 870 28 Cytomegaloviruses Cytomegaloviruses NNPS cord-016990-ot1wi3xi 870 29 and and CC cord-016990-ot1wi3xi 870 30 their -PRON- PRP$ cord-016990-ot1wi3xi 870 31 replication replication NN cord-016990-ot1wi3xi 870 32 Human human NN cord-016990-ot1wi3xi 870 33 cytomegalovirus cytomegalovirus NN cord-016990-ot1wi3xi 870 34 . . . cord-016990-ot1wi3xi 871 1 Morphology morphology NN cord-016990-ot1wi3xi 871 2 by by IN cord-016990-ot1wi3xi 871 3 negative negative JJ cord-016990-ot1wi3xi 871 4 staining stain VBG cord-016990-ot1wi3xi 871 5 Infectiousmononucleosis Infectiousmononucleosis NNP cord-016990-ot1wi3xi 871 6 - - HYPH cord-016990-ot1wi3xi 871 7 like like JJ cord-016990-ot1wi3xi 871 8 disease disease NN cord-016990-ot1wi3xi 871 9 with with IN cord-016990-ot1wi3xi 871 10 negative negative JJ cord-016990-ot1wi3xi 871 11 heterophil heterophil NNP cord-016990-ot1wi3xi 871 12 agglutination agglutination NN cord-016990-ot1wi3xi 871 13 test test NN cord-016990-ot1wi3xi 871 14 . . . cord-016990-ot1wi3xi 872 1 Clinical clinical JJ cord-016990-ot1wi3xi 872 2 features feature NNS cord-016990-ot1wi3xi 872 3 in in IN cord-016990-ot1wi3xi 872 4 relation relation NN cord-016990-ot1wi3xi 872 5 to to IN cord-016990-ot1wi3xi 872 6 Epstein Epstein NNP cord-016990-ot1wi3xi 872 7 - - HYPH cord-016990-ot1wi3xi 872 8 Barr Barr NNP cord-016990-ot1wi3xi 872 9 virus virus NN cord-016990-ot1wi3xi 872 10 and and CC cord-016990-ot1wi3xi 872 11 cytomegalovirus cytomegalovirus NN cord-016990-ot1wi3xi 872 12 antibodies antibody NNS cord-016990-ot1wi3xi 872 13 Cytomegalovirus Cytomegalovirus NNP cord-016990-ot1wi3xi 872 14 infection infection NN cord-016990-ot1wi3xi 872 15 in in IN cord-016990-ot1wi3xi 872 16 the the DT cord-016990-ot1wi3xi 872 17 normal normal JJ cord-016990-ot1wi3xi 872 18 host host NN cord-016990-ot1wi3xi 872 19 Cytomegalic Cytomegalic NNP cord-016990-ot1wi3xi 872 20 inclusion inclusion NN cord-016990-ot1wi3xi 872 21 disease disease NN cord-016990-ot1wi3xi 872 22 ; ; : cord-016990-ot1wi3xi 872 23 an an DT cord-016990-ot1wi3xi 872 24 analysis analysis NN cord-016990-ot1wi3xi 872 25 of of IN cord-016990-ot1wi3xi 872 26 the the DT cord-016990-ot1wi3xi 872 27 clinical clinical JJ cord-016990-ot1wi3xi 872 28 features feature NNS cord-016990-ot1wi3xi 872 29 based base VBN cord-016990-ot1wi3xi 872 30 on on IN cord-016990-ot1wi3xi 872 31 the the DT cord-016990-ot1wi3xi 872 32 literature literature NN cord-016990-ot1wi3xi 872 33 and and CC cord-016990-ot1wi3xi 872 34 six six CD cord-016990-ot1wi3xi 872 35 additional additional JJ cord-016990-ot1wi3xi 872 36 cases case NNS cord-016990-ot1wi3xi 872 37 Cytomegalovirus Cytomegalovirus NNP cord-016990-ot1wi3xi 872 38 pneumonia pneumonia NN cord-016990-ot1wi3xi 872 39 in in IN cord-016990-ot1wi3xi 872 40 transplant transplant NN cord-016990-ot1wi3xi 872 41 recipients recipient NNS cord-016990-ot1wi3xi 873 1 Nonbacterial nonbacterial JJ cord-016990-ot1wi3xi 873 2 pneumonia pneumonia NN cord-016990-ot1wi3xi 873 3 after after IN cord-016990-ot1wi3xi 873 4 allogeneic allogeneic NN cord-016990-ot1wi3xi 873 5 marrow marrow NN cord-016990-ot1wi3xi 873 6 transplantation transplantation NN cord-016990-ot1wi3xi 874 1 : : : cord-016990-ot1wi3xi 874 2 a a DT cord-016990-ot1wi3xi 874 3 review review NN cord-016990-ot1wi3xi 874 4 of of IN cord-016990-ot1wi3xi 874 5 ten ten CD cord-016990-ot1wi3xi 874 6 years year NNS cord-016990-ot1wi3xi 874 7 ' ' POS cord-016990-ot1wi3xi 874 8 experience experience NN cord-016990-ot1wi3xi 874 9 Pulmonary pulmonary JJ cord-016990-ot1wi3xi 874 10 complications complication NNS cord-016990-ot1wi3xi 874 11 of of IN cord-016990-ot1wi3xi 874 12 solid solid JJ cord-016990-ot1wi3xi 874 13 organ organ NN cord-016990-ot1wi3xi 874 14 and and CC cord-016990-ot1wi3xi 874 15 hematopoietic hematopoietic JJ cord-016990-ot1wi3xi 874 16 stem stem NN cord-016990-ot1wi3xi 874 17 cell cell NN cord-016990-ot1wi3xi 874 18 transplantation transplantation NN cord-016990-ot1wi3xi 874 19 Lungs lung NNS cord-016990-ot1wi3xi 874 20 are be VBP cord-016990-ot1wi3xi 874 21 a a DT cord-016990-ot1wi3xi 874 22 major major JJ cord-016990-ot1wi3xi 874 23 organ organ NN cord-016990-ot1wi3xi 874 24 site site NN cord-016990-ot1wi3xi 874 25 of of IN cord-016990-ot1wi3xi 874 26 cytomegalovirus cytomegalovirus NN cord-016990-ot1wi3xi 874 27 latency latency NN cord-016990-ot1wi3xi 874 28 and and CC cord-016990-ot1wi3xi 874 29 recurrence recurrence NN cord-016990-ot1wi3xi 874 30 Spectrum Spectrum NNP cord-016990-ot1wi3xi 874 31 of of IN cord-016990-ot1wi3xi 874 32 pulmonary pulmonary JJ cord-016990-ot1wi3xi 874 33 diseases disease NNS cord-016990-ot1wi3xi 874 34 associated associate VBN cord-016990-ot1wi3xi 874 35 with with IN cord-016990-ot1wi3xi 874 36 the the DT cord-016990-ot1wi3xi 874 37 acquired acquire VBN cord-016990-ot1wi3xi 874 38 immune immune JJ cord-016990-ot1wi3xi 874 39 deficiency deficiency NN cord-016990-ot1wi3xi 874 40 syndrome syndrome NN cord-016990-ot1wi3xi 874 41 Cytomegalovirus Cytomegalovirus NNP cord-016990-ot1wi3xi 874 42 - - HYPH cord-016990-ot1wi3xi 874 43 induced induce VBN cord-016990-ot1wi3xi 874 44 alveolar alveolar NN cord-016990-ot1wi3xi 874 45 hemorrhage hemorrhage NN cord-016990-ot1wi3xi 874 46 in in IN cord-016990-ot1wi3xi 874 47 patients patient NNS cord-016990-ot1wi3xi 874 48 with with IN cord-016990-ot1wi3xi 874 49 AIDS AIDS NNP cord-016990-ot1wi3xi 874 50 : : : cord-016990-ot1wi3xi 874 51 a a DT cord-016990-ot1wi3xi 874 52 new new JJ cord-016990-ot1wi3xi 874 53 clinical clinical JJ cord-016990-ot1wi3xi 874 54 entity entity NN cord-016990-ot1wi3xi 874 55 ? ? . cord-016990-ot1wi3xi 875 1 Widespread widespread JJ cord-016990-ot1wi3xi 875 2 presence presence NN cord-016990-ot1wi3xi 875 3 of of IN cord-016990-ot1wi3xi 875 4 histologically histologically RB cord-016990-ot1wi3xi 875 5 occult occult JJ cord-016990-ot1wi3xi 875 6 cytomegalovirus cytomegalovirus NN cord-016990-ot1wi3xi 875 7 Cytomegalovirus Cytomegalovirus NNP cord-016990-ot1wi3xi 875 8 pneumonia pneumonia NN cord-016990-ot1wi3xi 875 9 in in IN cord-016990-ot1wi3xi 875 10 bone bone NN cord-016990-ot1wi3xi 875 11 marrow marrow NN cord-016990-ot1wi3xi 875 12 transplant transplant NN cord-016990-ot1wi3xi 875 13 recipients recipient NNS cord-016990-ot1wi3xi 875 14 : : : cord-016990-ot1wi3xi 875 15 miliary miliary JJ cord-016990-ot1wi3xi 875 16 and and CC cord-016990-ot1wi3xi 875 17 diffuse diffuse JJ cord-016990-ot1wi3xi 875 18 patterns pattern NNS cord-016990-ot1wi3xi 876 1 Cytomegalovirus Cytomegalovirus NNP cord-016990-ot1wi3xi 876 2 pneumonitis pneumonitis NN cord-016990-ot1wi3xi 876 3 in in IN cord-016990-ot1wi3xi 876 4 patients patient NNS cord-016990-ot1wi3xi 876 5 with with IN cord-016990-ot1wi3xi 876 6 AIDS AIDS NNP cord-016990-ot1wi3xi 876 7 . . . cord-016990-ot1wi3xi 877 1 Findings finding NNS cord-016990-ot1wi3xi 877 2 in in IN cord-016990-ot1wi3xi 877 3 an an DT cord-016990-ot1wi3xi 877 4 autopsy autopsy JJ cord-016990-ot1wi3xi 877 5 series series NN cord-016990-ot1wi3xi 877 6 Light Light NNP cord-016990-ot1wi3xi 877 7 microscopy microscopy NNS cord-016990-ot1wi3xi 877 8 of of IN cord-016990-ot1wi3xi 877 9 selected select VBN cord-016990-ot1wi3xi 877 10 viral viral JJ cord-016990-ot1wi3xi 877 11 diseases disease NNS cord-016990-ot1wi3xi 877 12 ( ( -LRB- cord-016990-ot1wi3xi 877 13 morphology morphology NN cord-016990-ot1wi3xi 877 14 of of IN cord-016990-ot1wi3xi 877 15 viral viral JJ cord-016990-ot1wi3xi 877 16 inclusion inclusion NN cord-016990-ot1wi3xi 877 17 bodies body NNS cord-016990-ot1wi3xi 877 18 ) ) -RRB- cord-016990-ot1wi3xi 877 19 Human human JJ cord-016990-ot1wi3xi 877 20 cytomegalovirus cytomegalovirus NN cord-016990-ot1wi3xi 877 21 infection infection NN cord-016990-ot1wi3xi 877 22 of of IN cord-016990-ot1wi3xi 877 23 cultured cultured JJ cord-016990-ot1wi3xi 877 24 fibroblasts fibroblast NNS cord-016990-ot1wi3xi 877 25 . . . cord-016990-ot1wi3xi 878 1 II II NNP cord-016990-ot1wi3xi 878 2 . . . cord-016990-ot1wi3xi 879 1 Viral viral JJ cord-016990-ot1wi3xi 879 2 replicative replicative JJ cord-016990-ot1wi3xi 879 3 sequence sequence NN cord-016990-ot1wi3xi 879 4 of of IN cord-016990-ot1wi3xi 879 5 a a DT cord-016990-ot1wi3xi 879 6 wild wild JJ cord-016990-ot1wi3xi 879 7 and and CC cord-016990-ot1wi3xi 879 8 an an DT cord-016990-ot1wi3xi 879 9 adapted adapt VBN cord-016990-ot1wi3xi 879 10 strain strain NN cord-016990-ot1wi3xi 880 1 Staining stain VBG cord-016990-ot1wi3xi 880 2 qualities quality NNS cord-016990-ot1wi3xi 880 3 of of IN cord-016990-ot1wi3xi 880 4 cytomegalovirus cytomegalovirus JJ cord-016990-ot1wi3xi 880 5 inclusions inclusion NNS cord-016990-ot1wi3xi 880 6 in in IN cord-016990-ot1wi3xi 880 7 the the DT cord-016990-ot1wi3xi 880 8 lungs lung NNS cord-016990-ot1wi3xi 880 9 of of IN cord-016990-ot1wi3xi 880 10 patients patient NNS cord-016990-ot1wi3xi 880 11 with with IN cord-016990-ot1wi3xi 880 12 the the DT cord-016990-ot1wi3xi 880 13 acquired acquire VBN cord-016990-ot1wi3xi 880 14 immunodeficiency immunodeficiency NNP cord-016990-ot1wi3xi 880 15 syndrome syndrome NN cord-016990-ot1wi3xi 880 16 : : : cord-016990-ot1wi3xi 880 17 a a DT cord-016990-ot1wi3xi 880 18 potential potential JJ cord-016990-ot1wi3xi 880 19 source source NN cord-016990-ot1wi3xi 880 20 of of IN cord-016990-ot1wi3xi 880 21 diagnostic diagnostic JJ cord-016990-ot1wi3xi 880 22 misinterpretation misinterpretation NN cord-016990-ot1wi3xi 880 23 Definitions definition NNS cord-016990-ot1wi3xi 880 24 of of IN cord-016990-ot1wi3xi 880 25 cytomegalovirus cytomegalovirus JJ cord-016990-ot1wi3xi 880 26 infection infection NN cord-016990-ot1wi3xi 880 27 and and CC cord-016990-ot1wi3xi 880 28 disease disease NN cord-016990-ot1wi3xi 880 29 in in IN cord-016990-ot1wi3xi 880 30 transplant transplant NN cord-016990-ot1wi3xi 880 31 recipients recipient NNS cord-016990-ot1wi3xi 880 32 Direct direct JJ cord-016990-ot1wi3xi 880 33 detection detection NN cord-016990-ot1wi3xi 880 34 of of IN cord-016990-ot1wi3xi 880 35 cytomegalovirus cytomegalovirus NN cord-016990-ot1wi3xi 880 36 from from IN cord-016990-ot1wi3xi 880 37 bronchoalveolar bronchoalveolar NNP cord-016990-ot1wi3xi 880 38 lavage lavage NN cord-016990-ot1wi3xi 880 39 samples sample NNS cord-016990-ot1wi3xi 880 40 by by IN cord-016990-ot1wi3xi 880 41 using use VBG cord-016990-ot1wi3xi 880 42 a a DT cord-016990-ot1wi3xi 880 43 rapid rapid JJ cord-016990-ot1wi3xi 880 44 in in IN cord-016990-ot1wi3xi 880 45 situ situ JJ cord-016990-ot1wi3xi 880 46 DNA dna NN cord-016990-ot1wi3xi 880 47 hybridization hybridization NN cord-016990-ot1wi3xi 880 48 assay assay NN cord-016990-ot1wi3xi 880 49 Pathology pathology NN cord-016990-ot1wi3xi 880 50 of of IN cord-016990-ot1wi3xi 880 51 neonatal neonatal JJ cord-016990-ot1wi3xi 880 52 Herpes Herpes NNP cord-016990-ot1wi3xi 880 53 simplex simplex NN cord-016990-ot1wi3xi 880 54 virus virus NN cord-016990-ot1wi3xi 880 55 infection infection NN cord-016990-ot1wi3xi 880 56 Varicella Varicella NNP cord-016990-ot1wi3xi 880 57 zoster zoster NN cord-016990-ot1wi3xi 880 58 and and CC cord-016990-ot1wi3xi 881 1 herpes herpes NNP cord-016990-ot1wi3xi 881 2 simplex simplex NNP cord-016990-ot1wi3xi 881 3 virus virus NN cord-016990-ot1wi3xi 881 4 pneumonias pneumonia NNS cord-016990-ot1wi3xi 881 5 Viral Viral NNP cord-016990-ot1wi3xi 881 6 Infections Infections NNPS cord-016990-ot1wi3xi 881 7 of of IN cord-016990-ot1wi3xi 881 8 the the DT cord-016990-ot1wi3xi 881 9 Lung Lung NNP cord-016990-ot1wi3xi 881 10 Herpes Herpes NNP cord-016990-ot1wi3xi 881 11 simplex simplex NN cord-016990-ot1wi3xi 882 1 viruses virus NNS cord-016990-ot1wi3xi 882 2 Recovery Recovery NNP cord-016990-ot1wi3xi 882 3 of of IN cord-016990-ot1wi3xi 882 4 herpes herpes NNP cord-016990-ot1wi3xi 882 5 simplex simplex NN cord-016990-ot1wi3xi 882 6 virus virus NN cord-016990-ot1wi3xi 882 7 from from IN cord-016990-ot1wi3xi 882 8 human human JJ cord-016990-ot1wi3xi 882 9 sacral sacral JJ cord-016990-ot1wi3xi 882 10 ganglions ganglion NNS cord-016990-ot1wi3xi 882 11 Herpesvirus Herpesvirus NNP cord-016990-ot1wi3xi 882 12 hominis hominis NN cord-016990-ot1wi3xi 882 13 : : : cord-016990-ot1wi3xi 883 1 isolation isolation NN cord-016990-ot1wi3xi 883 2 from from IN cord-016990-ot1wi3xi 883 3 human human JJ cord-016990-ot1wi3xi 883 4 trigeminal trigeminal JJ cord-016990-ot1wi3xi 883 5 ganglion ganglion NN cord-016990-ot1wi3xi 883 6 Infections Infections NNPS cord-016990-ot1wi3xi 883 7 with with IN cord-016990-ot1wi3xi 883 8 herpes herpes NN cord-016990-ot1wi3xi 883 9 simplex simplex NN cord-016990-ot1wi3xi 883 10 viruses virus NNS cord-016990-ot1wi3xi 883 11 ( ( -LRB- cord-016990-ot1wi3xi 883 12 1 1 CD cord-016990-ot1wi3xi 883 13 ) ) -RRB- cord-016990-ot1wi3xi 883 14 Infections infection NNS cord-016990-ot1wi3xi 883 15 with with IN cord-016990-ot1wi3xi 883 16 herpes herpes NN cord-016990-ot1wi3xi 883 17 simplex simplex NN cord-016990-ot1wi3xi 883 18 viruses virus NNS cord-016990-ot1wi3xi 883 19 ( ( -LRB- cord-016990-ot1wi3xi 883 20 2 2 CD cord-016990-ot1wi3xi 883 21 ) ) -RRB- cord-016990-ot1wi3xi 884 1 Herpetic herpetic JJ cord-016990-ot1wi3xi 884 2 infection infection NN cord-016990-ot1wi3xi 884 3 of of IN cord-016990-ot1wi3xi 884 4 the the DT cord-016990-ot1wi3xi 884 5 middle middle NN cord-016990-ot1wi3xi 884 6 and and CC cord-016990-ot1wi3xi 884 7 lower low JJR cord-016990-ot1wi3xi 884 8 respiratory respiratory JJ cord-016990-ot1wi3xi 884 9 tract tract NN cord-016990-ot1wi3xi 884 10 Herpes Herpes NNP cord-016990-ot1wi3xi 884 11 simplex simplex NN cord-016990-ot1wi3xi 884 12 virus virus NN cord-016990-ot1wi3xi 884 13 pneumonia pneumonia NN cord-016990-ot1wi3xi 884 14 : : : cord-016990-ot1wi3xi 884 15 clinical clinical JJ cord-016990-ot1wi3xi 884 16 , , , cord-016990-ot1wi3xi 884 17 virologic virologic NNP cord-016990-ot1wi3xi 884 18 , , , cord-016990-ot1wi3xi 884 19 and and CC cord-016990-ot1wi3xi 884 20 pathologic pathologic JJ cord-016990-ot1wi3xi 884 21 features feature NNS cord-016990-ot1wi3xi 884 22 in in IN cord-016990-ot1wi3xi 884 23 20 20 CD cord-016990-ot1wi3xi 884 24 patients patient NNS cord-016990-ot1wi3xi 885 1 Herpes Herpes NNP cord-016990-ot1wi3xi 885 2 simplex simplex NN cord-016990-ot1wi3xi 885 3 virus virus NN cord-016990-ot1wi3xi 885 4 pneumonia pneumonia NN cord-016990-ot1wi3xi 885 5 in in IN cord-016990-ot1wi3xi 885 6 trauma trauma NN cord-016990-ot1wi3xi 885 7 patients patient NNS cord-016990-ot1wi3xi 886 1 Herpes Herpes NNP cord-016990-ot1wi3xi 886 2 simplex simplex NN cord-016990-ot1wi3xi 886 3 virus virus NN cord-016990-ot1wi3xi 886 4 pneumonia pneumonia NN cord-016990-ot1wi3xi 886 5 during during IN cord-016990-ot1wi3xi 886 6 standard standard JJ cord-016990-ot1wi3xi 886 7 induction induction NN cord-016990-ot1wi3xi 886 8 chemotherapy chemotherapy NN cord-016990-ot1wi3xi 886 9 for for IN cord-016990-ot1wi3xi 886 10 acute acute JJ cord-016990-ot1wi3xi 886 11 leukemia leukemia NN cord-016990-ot1wi3xi 886 12 : : : cord-016990-ot1wi3xi 887 1 case case NNP cord-016990-ot1wi3xi 887 2 report report NN cord-016990-ot1wi3xi 887 3 and and CC cord-016990-ot1wi3xi 887 4 review review NN cord-016990-ot1wi3xi 887 5 of of IN cord-016990-ot1wi3xi 887 6 literature literature NN cord-016990-ot1wi3xi 887 7 Hepato hepato NN cord-016990-ot1wi3xi 887 8 - - HYPH cord-016990-ot1wi3xi 887 9 adrenal adrenal JJ cord-016990-ot1wi3xi 887 10 necrosis necrosis NN cord-016990-ot1wi3xi 887 11 with with IN cord-016990-ot1wi3xi 887 12 intranuclear intranuclear NN cord-016990-ot1wi3xi 887 13 inclusion inclusion NN cord-016990-ot1wi3xi 887 14 bodies body NNS cord-016990-ot1wi3xi 887 15 Usefulness Usefulness NNP cord-016990-ot1wi3xi 887 16 of of IN cord-016990-ot1wi3xi 887 17 clinical clinical JJ cord-016990-ot1wi3xi 887 18 features feature NNS cord-016990-ot1wi3xi 887 19 and and CC cord-016990-ot1wi3xi 887 20 liver liver NN cord-016990-ot1wi3xi 887 21 biopsy biopsy NN cord-016990-ot1wi3xi 887 22 in in IN cord-016990-ot1wi3xi 887 23 diagnosis diagnosis NN cord-016990-ot1wi3xi 887 24 of of IN cord-016990-ot1wi3xi 887 25 disseminated disseminate VBN cord-016990-ot1wi3xi 887 26 herpes herpes NN cord-016990-ot1wi3xi 887 27 simplex simplex NN cord-016990-ot1wi3xi 887 28 infection infection NN cord-016990-ot1wi3xi 887 29 Neonatal neonatal JJ cord-016990-ot1wi3xi 887 30 herpes herpe NNS cord-016990-ot1wi3xi 887 31 simplex simplex NN cord-016990-ot1wi3xi 887 32 infection infection NN cord-016990-ot1wi3xi 887 33 Neonatal neonatal JJ cord-016990-ot1wi3xi 887 34 herpes herpe NNS cord-016990-ot1wi3xi 887 35 simplex simplex NN cord-016990-ot1wi3xi 887 36 pneumonia pneumonia NN cord-016990-ot1wi3xi 887 37 Calcification calcification NN cord-016990-ot1wi3xi 887 38 in in IN cord-016990-ot1wi3xi 887 39 the the DT cord-016990-ot1wi3xi 887 40 adrenal adrenal JJ cord-016990-ot1wi3xi 887 41 glands gland NNS cord-016990-ot1wi3xi 887 42 associated associate VBN cord-016990-ot1wi3xi 887 43 with with IN cord-016990-ot1wi3xi 887 44 disseminated disseminate VBN cord-016990-ot1wi3xi 887 45 herpes herpes NN cord-016990-ot1wi3xi 887 46 simplex simplex NN cord-016990-ot1wi3xi 887 47 infection infection NN cord-016990-ot1wi3xi 887 48 Necrotizing necrotize VBG cord-016990-ot1wi3xi 887 49 tracheobronchitis tracheobronchitis NN cord-016990-ot1wi3xi 887 50 and and CC cord-016990-ot1wi3xi 887 51 bronchopneumonia bronchopneumonia NN cord-016990-ot1wi3xi 887 52 consistent consistent JJ cord-016990-ot1wi3xi 887 53 with with IN cord-016990-ot1wi3xi 887 54 herpetic herpetic JJ cord-016990-ot1wi3xi 887 55 infection infection NN cord-016990-ot1wi3xi 888 1 Herpetic Herpetic NNP cord-016990-ot1wi3xi 888 2 tracheobronchitis tracheobronchitis NN cord-016990-ot1wi3xi 888 3 Herpes Herpes NNP cord-016990-ot1wi3xi 888 4 simplex simplex NN cord-016990-ot1wi3xi 888 5 virus virus NN cord-016990-ot1wi3xi 888 6 infection infection NN cord-016990-ot1wi3xi 888 7 of of IN cord-016990-ot1wi3xi 888 8 the the DT cord-016990-ot1wi3xi 888 9 adult adult NN cord-016990-ot1wi3xi 888 10 lower low JJR cord-016990-ot1wi3xi 888 11 respiratory respiratory JJ cord-016990-ot1wi3xi 888 12 tract tract NN cord-016990-ot1wi3xi 888 13 Isolation isolation NN cord-016990-ot1wi3xi 888 14 of of IN cord-016990-ot1wi3xi 888 15 herpes herpe NNS cord-016990-ot1wi3xi 888 16 virus virus NN cord-016990-ot1wi3xi 888 17 from from IN cord-016990-ot1wi3xi 888 18 a a DT cord-016990-ot1wi3xi 888 19 case case NN cord-016990-ot1wi3xi 888 20 of of IN cord-016990-ot1wi3xi 888 21 atypical atypical JJ cord-016990-ot1wi3xi 888 22 pneumonia pneumonia NN cord-016990-ot1wi3xi 888 23 and and CC cord-016990-ot1wi3xi 888 24 erythema erythema NN cord-016990-ot1wi3xi 888 25 multiforme multiforme NNP cord-016990-ot1wi3xi 888 26 exudativum exudativum NNP cord-016990-ot1wi3xi 888 27 Herpes Herpes NNP cord-016990-ot1wi3xi 888 28 simplex simplex NN cord-016990-ot1wi3xi 888 29 virus virus NN cord-016990-ot1wi3xi 888 30 - - : cord-016990-ot1wi3xi 888 31 the the DT cord-016990-ot1wi3xi 888 32 most most RBS cord-016990-ot1wi3xi 888 33 frequently frequently RB cord-016990-ot1wi3xi 888 34 isolated isolate VBN cord-016990-ot1wi3xi 888 35 pathogen pathogen NN cord-016990-ot1wi3xi 888 36 in in IN cord-016990-ot1wi3xi 888 37 the the DT cord-016990-ot1wi3xi 888 38 lungs lung NNS cord-016990-ot1wi3xi 888 39 of of IN cord-016990-ot1wi3xi 888 40 patients patient NNS cord-016990-ot1wi3xi 888 41 with with IN cord-016990-ot1wi3xi 888 42 severe severe JJ cord-016990-ot1wi3xi 888 43 respiratory respiratory JJ cord-016990-ot1wi3xi 888 44 distress distress NN cord-016990-ot1wi3xi 888 45 Herpes Herpes NNP cord-016990-ot1wi3xi 888 46 simplex simplex NN cord-016990-ot1wi3xi 888 47 virus virus NN cord-016990-ot1wi3xi 888 48 from from IN cord-016990-ot1wi3xi 888 49 the the DT cord-016990-ot1wi3xi 888 50 lower low JJR cord-016990-ot1wi3xi 888 51 respiratory respiratory JJ cord-016990-ot1wi3xi 888 52 tract tract NN cord-016990-ot1wi3xi 888 53 in in IN cord-016990-ot1wi3xi 888 54 adult adult JJ cord-016990-ot1wi3xi 888 55 respiratory respiratory JJ cord-016990-ot1wi3xi 888 56 distress distress NN cord-016990-ot1wi3xi 888 57 syndrome syndrome NN cord-016990-ot1wi3xi 889 1 The the DT cord-016990-ot1wi3xi 889 2 problem problem NN cord-016990-ot1wi3xi 889 3 of of IN cord-016990-ot1wi3xi 889 4 intranuclear intranuclear NN cord-016990-ot1wi3xi 889 5 inclusions inclusion NNS cord-016990-ot1wi3xi 889 6 in in IN cord-016990-ot1wi3xi 889 7 virus virus NN cord-016990-ot1wi3xi 889 8 diseases disease NNS cord-016990-ot1wi3xi 889 9 Comparison comparison NN cord-016990-ot1wi3xi 889 10 of of IN cord-016990-ot1wi3xi 889 11 in in IN cord-016990-ot1wi3xi 889 12 situ situ NN cord-016990-ot1wi3xi 889 13 hybridization hybridization NN cord-016990-ot1wi3xi 889 14 and and CC cord-016990-ot1wi3xi 889 15 immunohistochemistry immunohistochemistry NN cord-016990-ot1wi3xi 889 16 for for IN cord-016990-ot1wi3xi 889 17 detection detection NN cord-016990-ot1wi3xi 889 18 of of IN cord-016990-ot1wi3xi 889 19 cytomegalovirus cytomegalovirus NNP cord-016990-ot1wi3xi 889 20 and and CC cord-016990-ot1wi3xi 889 21 herpes herpes NN cord-016990-ot1wi3xi 889 22 simplex simplex NNP cord-016990-ot1wi3xi 889 23 virus virus NN cord-016990-ot1wi3xi 889 24 Varicella varicella NN cord-016990-ot1wi3xi 889 25 - - HYPH cord-016990-ot1wi3xi 889 26 zoster zoster NN cord-016990-ot1wi3xi 889 27 virus virus NN cord-016990-ot1wi3xi 889 28 Varicella varicella NN cord-016990-ot1wi3xi 889 29 - - HYPH cord-016990-ot1wi3xi 889 30 zoster zoster NN cord-016990-ot1wi3xi 889 31 virus virus NN cord-016990-ot1wi3xi 889 32 : : : cord-016990-ot1wi3xi 889 33 pathogenesis pathogenesis NN cord-016990-ot1wi3xi 889 34 of of IN cord-016990-ot1wi3xi 889 35 latency latency NN cord-016990-ot1wi3xi 889 36 and and CC cord-016990-ot1wi3xi 889 37 reactivation reactivation NN cord-016990-ot1wi3xi 889 38 Varicella varicella NN cord-016990-ot1wi3xi 889 39 - - HYPH cord-016990-ot1wi3xi 889 40 related relate VBN cord-016990-ot1wi3xi 889 41 deaths death NNS cord-016990-ot1wi3xi 889 42 among among IN cord-016990-ot1wi3xi 889 43 adults adult NNS cord-016990-ot1wi3xi 889 44 - - : cord-016990-ot1wi3xi 889 45 United United NNP cord-016990-ot1wi3xi 889 46 States States NNP cord-016990-ot1wi3xi 889 47 Varicella Varicella NNP cord-016990-ot1wi3xi 889 48 pneumonia pneumonia NN cord-016990-ot1wi3xi 889 49 in in IN cord-016990-ot1wi3xi 889 50 adults adult NNS cord-016990-ot1wi3xi 890 1 Severe severe JJ cord-016990-ot1wi3xi 890 2 forms form NNS cord-016990-ot1wi3xi 890 3 of of IN cord-016990-ot1wi3xi 890 4 chickenpox chickenpox NN cord-016990-ot1wi3xi 890 5 in in IN cord-016990-ot1wi3xi 890 6 adults adult NNS cord-016990-ot1wi3xi 891 1 The the DT cord-016990-ot1wi3xi 891 2 epidemiology epidemiology NN cord-016990-ot1wi3xi 891 3 of of IN cord-016990-ot1wi3xi 891 4 varicella varicella NN cord-016990-ot1wi3xi 891 5 and and CC cord-016990-ot1wi3xi 891 6 its -PRON- PRP$ cord-016990-ot1wi3xi 891 7 complications complication NNS cord-016990-ot1wi3xi 891 8 Varicella Varicella NNP cord-016990-ot1wi3xi 891 9 pneumonia pneumonia NN cord-016990-ot1wi3xi 891 10 : : : cord-016990-ot1wi3xi 891 11 study study NN cord-016990-ot1wi3xi 891 12 of of IN cord-016990-ot1wi3xi 891 13 prevalence prevalence NN cord-016990-ot1wi3xi 891 14 in in IN cord-016990-ot1wi3xi 891 15 adult adult NN cord-016990-ot1wi3xi 891 16 men man NNS cord-016990-ot1wi3xi 891 17 Report Report NNP cord-016990-ot1wi3xi 891 18 of of IN cord-016990-ot1wi3xi 891 19 seven seven CD cord-016990-ot1wi3xi 891 20 cases case NNS cord-016990-ot1wi3xi 891 21 and and CC cord-016990-ot1wi3xi 891 22 a a DT cord-016990-ot1wi3xi 891 23 review review NN cord-016990-ot1wi3xi 891 24 of of IN cord-016990-ot1wi3xi 891 25 literature literature NN cord-016990-ot1wi3xi 891 26 Varicella varicella NN cord-016990-ot1wi3xi 891 27 - - HYPH cord-016990-ot1wi3xi 891 28 zoster zoster NN cord-016990-ot1wi3xi 891 29 virus virus NN cord-016990-ot1wi3xi 891 30 pneumonitis pneumonitis NN cord-016990-ot1wi3xi 891 31 Disseminated disseminate VBD cord-016990-ot1wi3xi 891 32 varicella varicella NN cord-016990-ot1wi3xi 891 33 infection infection NN cord-016990-ot1wi3xi 891 34 in in IN cord-016990-ot1wi3xi 891 35 adult adult NN cord-016990-ot1wi3xi 891 36 renal renal JJ cord-016990-ot1wi3xi 891 37 allograft allograft NN cord-016990-ot1wi3xi 891 38 recipients recipient NNS cord-016990-ot1wi3xi 891 39 : : : cord-016990-ot1wi3xi 891 40 four four CD cord-016990-ot1wi3xi 891 41 cases case NNS cord-016990-ot1wi3xi 891 42 and and CC cord-016990-ot1wi3xi 891 43 a a DT cord-016990-ot1wi3xi 891 44 review review NN cord-016990-ot1wi3xi 891 45 of of IN cord-016990-ot1wi3xi 891 46 the the DT cord-016990-ot1wi3xi 891 47 literature literature NN cord-016990-ot1wi3xi 891 48 Risk risk NN cord-016990-ot1wi3xi 891 49 factors factor NNS cord-016990-ot1wi3xi 891 50 and and CC cord-016990-ot1wi3xi 891 51 outcome outcome NN cord-016990-ot1wi3xi 891 52 of of IN cord-016990-ot1wi3xi 891 53 varicella varicella NN cord-016990-ot1wi3xi 891 54 - - HYPH cord-016990-ot1wi3xi 891 55 zoster zoster NN cord-016990-ot1wi3xi 891 56 virus virus NN cord-016990-ot1wi3xi 891 57 pneumonia pneumonia NN cord-016990-ot1wi3xi 891 58 in in IN cord-016990-ot1wi3xi 891 59 pregnant pregnant JJ cord-016990-ot1wi3xi 891 60 women woman NNS cord-016990-ot1wi3xi 891 61 Disseminated disseminate VBD cord-016990-ot1wi3xi 891 62 varicella varicella NN cord-016990-ot1wi3xi 891 63 at at IN cord-016990-ot1wi3xi 891 64 autopsy autopsy NN cord-016990-ot1wi3xi 891 65 in in IN cord-016990-ot1wi3xi 891 66 children child NNS cord-016990-ot1wi3xi 891 67 with with IN cord-016990-ot1wi3xi 891 68 cancer cancer NN cord-016990-ot1wi3xi 891 69 Roentgenographic roentgenographic JJ cord-016990-ot1wi3xi 891 70 manifestations manifestation NNS cord-016990-ot1wi3xi 891 71 of of IN cord-016990-ot1wi3xi 891 72 varicella varicella NN cord-016990-ot1wi3xi 891 73 pneumonia pneumonia NN cord-016990-ot1wi3xi 891 74 with with IN cord-016990-ot1wi3xi 891 75 postmortem postmortem JJ cord-016990-ot1wi3xi 891 76 correlation correlation NN cord-016990-ot1wi3xi 891 77 Visceral visceral JJ cord-016990-ot1wi3xi 891 78 lesions lesion NNS cord-016990-ot1wi3xi 891 79 associated associate VBN cord-016990-ot1wi3xi 891 80 with with IN cord-016990-ot1wi3xi 891 81 varicella varicella NN cord-016990-ot1wi3xi 891 82 Calcification calcification NN cord-016990-ot1wi3xi 891 83 in in IN cord-016990-ot1wi3xi 891 84 chickenpox chickenpox NN cord-016990-ot1wi3xi 891 85 pneumonia pneumonia NN cord-016990-ot1wi3xi 891 86 A a DT cord-016990-ot1wi3xi 891 87 survey survey NN cord-016990-ot1wi3xi 891 88 of of IN cord-016990-ot1wi3xi 891 89 pulmonary pulmonary JJ cord-016990-ot1wi3xi 891 90 calcification calcification NN cord-016990-ot1wi3xi 891 91 following follow VBG cord-016990-ot1wi3xi 891 92 adult adult NN cord-016990-ot1wi3xi 891 93 chicken chicken NN cord-016990-ot1wi3xi 891 94 - - HYPH cord-016990-ot1wi3xi 891 95 pox pox NN cord-016990-ot1wi3xi 891 96 Fulminant Fulminant NNP cord-016990-ot1wi3xi 891 97 disseminated disseminate VBD cord-016990-ot1wi3xi 891 98 varicella varicella NN cord-016990-ot1wi3xi 891 99 zoster zoster NN cord-016990-ot1wi3xi 891 100 virus virus NN cord-016990-ot1wi3xi 891 101 infection infection NN cord-016990-ot1wi3xi 891 102 without without IN cord-016990-ot1wi3xi 891 103 skin skin NN cord-016990-ot1wi3xi 891 104 involvement involvement NN cord-016990-ot1wi3xi 891 105 Cell cell NN cord-016990-ot1wi3xi 891 106 - - HYPH cord-016990-ot1wi3xi 891 107 free free JJ cord-016990-ot1wi3xi 891 108 varicella varicella NN cord-016990-ot1wi3xi 891 109 - - HYPH cord-016990-ot1wi3xi 891 110 zoster zoster NN cord-016990-ot1wi3xi 891 111 virus virus NN cord-016990-ot1wi3xi 891 112 in in IN cord-016990-ot1wi3xi 891 113 cultured cultured JJ cord-016990-ot1wi3xi 891 114 human human JJ cord-016990-ot1wi3xi 891 115 melanoma melanoma NN cord-016990-ot1wi3xi 891 116 cells cell NNS cord-016990-ot1wi3xi 891 117 Topley Topley NNP cord-016990-ot1wi3xi 891 118 and and CC cord-016990-ot1wi3xi 891 119 Wilson Wilson NNP cord-016990-ot1wi3xi 891 120 's 's POS cord-016990-ot1wi3xi 891 121 microbiology microbiology NN cord-016990-ot1wi3xi 891 122 and and CC cord-016990-ot1wi3xi 891 123 microbial microbial JJ cord-016990-ot1wi3xi 891 124 infections infection NNS cord-016990-ot1wi3xi 892 1 Changes change NNS cord-016990-ot1wi3xi 892 2 in in IN cord-016990-ot1wi3xi 892 3 the the DT cord-016990-ot1wi3xi 892 4 respiratory respiratory JJ cord-016990-ot1wi3xi 892 5 mucosa mucosa NN cord-016990-ot1wi3xi 892 6 resulting result VBG cord-016990-ot1wi3xi 892 7 from from IN cord-016990-ot1wi3xi 892 8 infection infection NN cord-016990-ot1wi3xi 892 9 with with IN cord-016990-ot1wi3xi 892 10 influenza influenza NN cord-016990-ot1wi3xi 892 11 virus virus NN cord-016990-ot1wi3xi 892 12 Bacteriology Bacteriology NNP cord-016990-ot1wi3xi 892 13 and and CC cord-016990-ot1wi3xi 892 14 histopathology histopathology NN cord-016990-ot1wi3xi 892 15 of of IN cord-016990-ot1wi3xi 892 16 the the DT cord-016990-ot1wi3xi 892 17 respiratory respiratory JJ cord-016990-ot1wi3xi 892 18 tract tract NN cord-016990-ot1wi3xi 892 19 and and CC cord-016990-ot1wi3xi 892 20 lungs lung NNS cord-016990-ot1wi3xi 892 21 in in IN cord-016990-ot1wi3xi 892 22 fatal fatal JJ cord-016990-ot1wi3xi 892 23 Asian asian JJ cord-016990-ot1wi3xi 892 24 influenza influenza NN cord-016990-ot1wi3xi 892 25 Asian asian JJ cord-016990-ot1wi3xi 892 26 influenza influenza NN cord-016990-ot1wi3xi 892 27 A a NN cord-016990-ot1wi3xi 892 28 in in IN cord-016990-ot1wi3xi 892 29 Boston Boston NNP cord-016990-ot1wi3xi 892 30 , , , cord-016990-ot1wi3xi 892 31 1957 1957 CD cord-016990-ot1wi3xi 892 32 - - SYM cord-016990-ot1wi3xi 892 33 1958 1958 CD cord-016990-ot1wi3xi 892 34 . . . cord-016990-ot1wi3xi 893 1 I. I. NNP cord-016990-ot1wi3xi 893 2 Observations Observations NNP cord-016990-ot1wi3xi 893 3 in in IN cord-016990-ot1wi3xi 893 4 thirty thirty CD cord-016990-ot1wi3xi 893 5 - - HYPH cord-016990-ot1wi3xi 893 6 two two CD cord-016990-ot1wi3xi 893 7 influenza influenza NN cord-016990-ot1wi3xi 893 8 - - HYPH cord-016990-ot1wi3xi 893 9 associated associate VBN cord-016990-ot1wi3xi 893 10 fatal fatal JJ cord-016990-ot1wi3xi 893 11 cases case NNS cord-016990-ot1wi3xi 893 12 Asian asian JJ cord-016990-ot1wi3xi 893 13 influenza influenza NN cord-016990-ot1wi3xi 893 14 A a NN cord-016990-ot1wi3xi 893 15 in in IN cord-016990-ot1wi3xi 893 16 Boston Boston NNP cord-016990-ot1wi3xi 893 17 , , , cord-016990-ot1wi3xi 893 18 1957 1957 CD cord-016990-ot1wi3xi 893 19 - - SYM cord-016990-ot1wi3xi 893 20 1958 1958 CD cord-016990-ot1wi3xi 893 21 . . . cord-016990-ot1wi3xi 894 1 II II NNP cord-016990-ot1wi3xi 894 2 . . . cord-016990-ot1wi3xi 895 1 Severe severe JJ cord-016990-ot1wi3xi 895 2 staphylococcal staphylococcal JJ cord-016990-ot1wi3xi 895 3 pneumonia pneumonia NN cord-016990-ot1wi3xi 895 4 complicating complicate VBG cord-016990-ot1wi3xi 895 5 influenza influenza NN cord-016990-ot1wi3xi 895 6 Fatal fatal JJ cord-016990-ot1wi3xi 895 7 diffuse diffuse NN cord-016990-ot1wi3xi 895 8 influenzal influenzal NN cord-016990-ot1wi3xi 895 9 pneumonia pneumonia NN cord-016990-ot1wi3xi 895 10 : : : cord-016990-ot1wi3xi 896 1 premortem premortem NNP cord-016990-ot1wi3xi 896 2 diagnosis diagnosis NN cord-016990-ot1wi3xi 896 3 by by IN cord-016990-ot1wi3xi 896 4 lung lung NN cord-016990-ot1wi3xi 896 5 biopsy biopsy NNP cord-016990-ot1wi3xi 896 6 Clinicopathologic Clinicopathologic NNP cord-016990-ot1wi3xi 896 7 study study NN cord-016990-ot1wi3xi 896 8 of of IN cord-016990-ot1wi3xi 896 9 thirty thirty CD cord-016990-ot1wi3xi 896 10 - - HYPH cord-016990-ot1wi3xi 896 11 three three CD cord-016990-ot1wi3xi 896 12 fatal fatal JJ cord-016990-ot1wi3xi 896 13 cases case NNS cord-016990-ot1wi3xi 896 14 of of IN cord-016990-ot1wi3xi 896 15 Asian asian JJ cord-016990-ot1wi3xi 896 16 influenza influenza NN cord-016990-ot1wi3xi 896 17 Pathologic pathologic JJ cord-016990-ot1wi3xi 896 18 features feature NNS cord-016990-ot1wi3xi 896 19 of of IN cord-016990-ot1wi3xi 896 20 lung lung NN cord-016990-ot1wi3xi 896 21 biopsy biopsy NN cord-016990-ot1wi3xi 896 22 specimens specimen NNS cord-016990-ot1wi3xi 896 23 from from IN cord-016990-ot1wi3xi 896 24 influenza influenza JJ cord-016990-ot1wi3xi 896 25 pneumonia pneumonia NN cord-016990-ot1wi3xi 896 26 cases case NNS cord-016990-ot1wi3xi 897 1 Bronchotracheal Bronchotracheal NNP cord-016990-ot1wi3xi 897 2 response response NN cord-016990-ot1wi3xi 897 3 in in IN cord-016990-ot1wi3xi 897 4 human human JJ cord-016990-ot1wi3xi 897 5 influenza influenza NN cord-016990-ot1wi3xi 897 6 . . . cord-016990-ot1wi3xi 898 1 Type type VB cord-016990-ot1wi3xi 898 2 A a NN cord-016990-ot1wi3xi 898 3 , , , cord-016990-ot1wi3xi 898 4 Asian asian JJ cord-016990-ot1wi3xi 898 5 strain strain NN cord-016990-ot1wi3xi 898 6 , , , cord-016990-ot1wi3xi 898 7 as as IN cord-016990-ot1wi3xi 898 8 studied study VBN cord-016990-ot1wi3xi 898 9 by by IN cord-016990-ot1wi3xi 898 10 light light NN cord-016990-ot1wi3xi 898 11 and and CC cord-016990-ot1wi3xi 898 12 electron electron NN cord-016990-ot1wi3xi 898 13 microscopic microscopic JJ cord-016990-ot1wi3xi 898 14 examination examination NN cord-016990-ot1wi3xi 898 15 of of IN cord-016990-ot1wi3xi 898 16 bronchoscopic bronchoscopic NNP cord-016990-ot1wi3xi 898 17 biopsies biopsy NNS cord-016990-ot1wi3xi 898 18 Influenza Influenza NNP cord-016990-ot1wi3xi 898 19 A a DT cord-016990-ot1wi3xi 898 20 virus virus NN cord-016990-ot1wi3xi 898 21 infection infection NN cord-016990-ot1wi3xi 898 22 complicated complicate VBN cord-016990-ot1wi3xi 898 23 by by IN cord-016990-ot1wi3xi 898 24 fatal fatal JJ cord-016990-ot1wi3xi 898 25 myocarditis myocarditis NN cord-016990-ot1wi3xi 898 26 Histopathologic Histopathologic NNP cord-016990-ot1wi3xi 898 27 and and CC cord-016990-ot1wi3xi 898 28 immunohistochemical immunohistochemical JJ cord-016990-ot1wi3xi 898 29 features feature NNS cord-016990-ot1wi3xi 898 30 of of IN cord-016990-ot1wi3xi 898 31 fatal fatal JJ cord-016990-ot1wi3xi 898 32 influenza influenza NN cord-016990-ot1wi3xi 898 33 virus virus NN cord-016990-ot1wi3xi 898 34 infections infection NNS cord-016990-ot1wi3xi 898 35 in in IN cord-016990-ot1wi3xi 898 36 children child NNS cord-016990-ot1wi3xi 898 37 during during IN cord-016990-ot1wi3xi 898 38 the the DT cord-016990-ot1wi3xi 898 39 2003 2003 CD cord-016990-ot1wi3xi 898 40 - - SYM cord-016990-ot1wi3xi 898 41 2004 2004 CD cord-016990-ot1wi3xi 898 42 season season NN cord-016990-ot1wi3xi 898 43 Probable probable JJ cord-016990-ot1wi3xi 898 44 person person NN cord-016990-ot1wi3xi 898 45 - - HYPH cord-016990-ot1wi3xi 898 46 to to IN cord-016990-ot1wi3xi 898 47 - - HYPH cord-016990-ot1wi3xi 898 48 person person NN cord-016990-ot1wi3xi 898 49 transmission transmission NN cord-016990-ot1wi3xi 898 50 of of IN cord-016990-ot1wi3xi 898 51 avian avian JJ cord-016990-ot1wi3xi 898 52 influenza influenza NN cord-016990-ot1wi3xi 898 53 A a NN cord-016990-ot1wi3xi 898 54 ( ( -LRB- cord-016990-ot1wi3xi 898 55 H5N1 H5N1 NNP cord-016990-ot1wi3xi 898 56 ) ) -RRB- cord-016990-ot1wi3xi 899 1 Influenza influenza NN cord-016990-ot1wi3xi 899 2 - - HYPH cord-016990-ot1wi3xi 899 3 associated associate VBN cord-016990-ot1wi3xi 899 4 deaths death NNS cord-016990-ot1wi3xi 899 5 among among IN cord-016990-ot1wi3xi 899 6 children child NNS cord-016990-ot1wi3xi 899 7 in in IN cord-016990-ot1wi3xi 899 8 the the DT cord-016990-ot1wi3xi 899 9 United United NNP cord-016990-ot1wi3xi 899 10 States States NNP cord-016990-ot1wi3xi 899 11 H5N1 H5N1 NNP cord-016990-ot1wi3xi 899 12 virus virus NN cord-016990-ot1wi3xi 899 13 attachment attachment NN cord-016990-ot1wi3xi 899 14 to to TO cord-016990-ot1wi3xi 899 15 lower lower VB cord-016990-ot1wi3xi 899 16 respiratory respiratory JJ cord-016990-ot1wi3xi 899 17 tract tract NN cord-016990-ot1wi3xi 899 18 Avian avian JJ cord-016990-ot1wi3xi 899 19 flu flu NN cord-016990-ot1wi3xi 899 20 : : : cord-016990-ot1wi3xi 899 21 influenza influenza NN cord-016990-ot1wi3xi 899 22 virus virus NN cord-016990-ot1wi3xi 899 23 receptors receptor NNS cord-016990-ot1wi3xi 899 24 in in IN cord-016990-ot1wi3xi 899 25 the the DT cord-016990-ot1wi3xi 899 26 human human JJ cord-016990-ot1wi3xi 899 27 airway airway NN cord-016990-ot1wi3xi 899 28 Influenza Influenza NNP cord-016990-ot1wi3xi 899 29 diagnosis diagnosis NN cord-016990-ot1wi3xi 899 30 and and CC cord-016990-ot1wi3xi 899 31 treatment treatment NN cord-016990-ot1wi3xi 899 32 in in IN cord-016990-ot1wi3xi 899 33 children child NNS cord-016990-ot1wi3xi 899 34 : : : cord-016990-ot1wi3xi 899 35 a a DT cord-016990-ot1wi3xi 899 36 review review NN cord-016990-ot1wi3xi 899 37 of of IN cord-016990-ot1wi3xi 899 38 studies study NNS cord-016990-ot1wi3xi 899 39 on on IN cord-016990-ot1wi3xi 899 40 clinically clinically RB cord-016990-ot1wi3xi 899 41 useful useful JJ cord-016990-ot1wi3xi 899 42 tests test NNS cord-016990-ot1wi3xi 899 43 and and CC cord-016990-ot1wi3xi 899 44 antiviral antiviral JJ cord-016990-ot1wi3xi 899 45 treatment treatment NN cord-016990-ot1wi3xi 899 46 for for IN cord-016990-ot1wi3xi 899 47 influenza influenza NN cord-016990-ot1wi3xi 899 48 Comparison comparison NN cord-016990-ot1wi3xi 899 49 of of IN cord-016990-ot1wi3xi 899 50 the the DT cord-016990-ot1wi3xi 899 51 Directigen Directigen NNP cord-016990-ot1wi3xi 899 52 flu flu NN cord-016990-ot1wi3xi 899 53 A+B A+B NNP cord-016990-ot1wi3xi 899 54 test test NN cord-016990-ot1wi3xi 899 55 , , , cord-016990-ot1wi3xi 899 56 the the DT cord-016990-ot1wi3xi 899 57 QuickVue QuickVue NNP cord-016990-ot1wi3xi 899 58 influenza influenza NN cord-016990-ot1wi3xi 899 59 test test NN cord-016990-ot1wi3xi 899 60 , , , cord-016990-ot1wi3xi 899 61 and and CC cord-016990-ot1wi3xi 899 62 clinical clinical JJ cord-016990-ot1wi3xi 899 63 case case NN cord-016990-ot1wi3xi 899 64 definition definition NN cord-016990-ot1wi3xi 899 65 to to IN cord-016990-ot1wi3xi 899 66 viral viral JJ cord-016990-ot1wi3xi 899 67 culture culture NN cord-016990-ot1wi3xi 899 68 and and CC cord-016990-ot1wi3xi 899 69 reverse reverse VB cord-016990-ot1wi3xi 899 70 transcription transcription NN cord-016990-ot1wi3xi 899 71 - - HYPH cord-016990-ot1wi3xi 899 72 PCR pcr NN cord-016990-ot1wi3xi 899 73 for for IN cord-016990-ot1wi3xi 899 74 rapid rapid JJ cord-016990-ot1wi3xi 899 75 diagnosis diagnosis NN cord-016990-ot1wi3xi 899 76 of of IN cord-016990-ot1wi3xi 899 77 influenza influenza NN cord-016990-ot1wi3xi 899 78 virus virus NN cord-016990-ot1wi3xi 899 79 infection infection NN cord-016990-ot1wi3xi 899 80 Paromyxoviridae Paromyxoviridae NNP cord-016990-ot1wi3xi 899 81 and and CC cord-016990-ot1wi3xi 899 82 their -PRON- PRP$ cord-016990-ot1wi3xi 899 83 replication replication NN cord-016990-ot1wi3xi 899 84 Electron electron NN cord-016990-ot1wi3xi 899 85 microscopy microscopy NN cord-016990-ot1wi3xi 899 86 in in IN cord-016990-ot1wi3xi 899 87 viral viral JJ cord-016990-ot1wi3xi 899 88 diagnosis diagnosis NN cord-016990-ot1wi3xi 899 89 Measles Measles NNP cord-016990-ot1wi3xi 899 90 surveillance surveillance NN cord-016990-ot1wi3xi 899 91 - - : cord-016990-ot1wi3xi 899 92 United United NNP cord-016990-ot1wi3xi 899 93 States States NNP cord-016990-ot1wi3xi 899 94 Modem Modem NNP cord-016990-ot1wi3xi 899 95 measles measle NNS cord-016990-ot1wi3xi 900 1 An an DT cord-016990-ot1wi3xi 900 2 experimental experimental JJ cord-016990-ot1wi3xi 900 3 demonstration demonstration NN cord-016990-ot1wi3xi 900 4 of of IN cord-016990-ot1wi3xi 900 5 the the DT cord-016990-ot1wi3xi 900 6 presence presence NN cord-016990-ot1wi3xi 900 7 of of IN cord-016990-ot1wi3xi 900 8 the the DT cord-016990-ot1wi3xi 900 9 virus virus NN cord-016990-ot1wi3xi 900 10 of of IN cord-016990-ot1wi3xi 900 11 measles measle NNS cord-016990-ot1wi3xi 900 12 in in IN cord-016990-ot1wi3xi 900 13 the the DT cord-016990-ot1wi3xi 900 14 mixed mixed JJ cord-016990-ot1wi3xi 900 15 buccal buccal JJ cord-016990-ot1wi3xi 900 16 and and CC cord-016990-ot1wi3xi 900 17 nasal nasal NN cord-016990-ot1wi3xi 900 18 secretions secretion NNS cord-016990-ot1wi3xi 900 19 Measles Measles NNP cord-016990-ot1wi3xi 900 20 virus virus NN cord-016990-ot1wi3xi 900 21 Measles Measles NNP cord-016990-ot1wi3xi 900 22 pneumonia pneumonia NN cord-016990-ot1wi3xi 900 23 in in IN cord-016990-ot1wi3xi 900 24 young young JJ cord-016990-ot1wi3xi 900 25 adults adult NNS cord-016990-ot1wi3xi 900 26 . . . cord-016990-ot1wi3xi 901 1 An an DT cord-016990-ot1wi3xi 901 2 analysis analysis NN cord-016990-ot1wi3xi 901 3 of of IN cord-016990-ot1wi3xi 901 4 106 106 CD cord-016990-ot1wi3xi 901 5 cases case NNS cord-016990-ot1wi3xi 902 1 Virus virus NN cord-016990-ot1wi3xi 902 2 pneumonia pneumonia NN cord-016990-ot1wi3xi 902 3 following follow VBG cord-016990-ot1wi3xi 902 4 measles measle NNS cord-016990-ot1wi3xi 902 5 : : : cord-016990-ot1wi3xi 902 6 a a DT cord-016990-ot1wi3xi 902 7 virological virological JJ cord-016990-ot1wi3xi 902 8 and and CC cord-016990-ot1wi3xi 902 9 histological histological JJ cord-016990-ot1wi3xi 902 10 study study NN cord-016990-ot1wi3xi 902 11 of of IN cord-016990-ot1wi3xi 902 12 autopsy autopsy JJ cord-016990-ot1wi3xi 902 13 material material NN cord-016990-ot1wi3xi 902 14 Measles Measles NNP cord-016990-ot1wi3xi 902 15 pneumonia pneumonia NN cord-016990-ot1wi3xi 902 16 and and CC cord-016990-ot1wi3xi 902 17 the the DT cord-016990-ot1wi3xi 902 18 nature nature NN cord-016990-ot1wi3xi 902 19 of of IN cord-016990-ot1wi3xi 902 20 the the DT cord-016990-ot1wi3xi 902 21 inclusion inclusion NN cord-016990-ot1wi3xi 902 22 - - HYPH cord-016990-ot1wi3xi 902 23 bearing bear VBG cord-016990-ot1wi3xi 902 24 giant giant JJ cord-016990-ot1wi3xi 902 25 cells cell NNS cord-016990-ot1wi3xi 902 26 : : : cord-016990-ot1wi3xi 902 27 a a DT cord-016990-ot1wi3xi 902 28 light light NN cord-016990-ot1wi3xi 902 29 - - HYPH cord-016990-ot1wi3xi 902 30 and and CC cord-016990-ot1wi3xi 902 31 electron electron NN cord-016990-ot1wi3xi 902 32 - - HYPH cord-016990-ot1wi3xi 902 33 microscope microscope NN cord-016990-ot1wi3xi 902 34 study study NN cord-016990-ot1wi3xi 902 35 Fatal fatal JJ cord-016990-ot1wi3xi 902 36 measles measles NN cord-016990-ot1wi3xi 902 37 infection infection NN cord-016990-ot1wi3xi 902 38 in in IN cord-016990-ot1wi3xi 902 39 children child NNS cord-016990-ot1wi3xi 902 40 with with IN cord-016990-ot1wi3xi 902 41 leukemia leukemia NN cord-016990-ot1wi3xi 902 42 Disseminated disseminate VBD cord-016990-ot1wi3xi 902 43 measles measles NN cord-016990-ot1wi3xi 902 44 infection infection NN cord-016990-ot1wi3xi 902 45 after after IN cord-016990-ot1wi3xi 902 46 vaccination vaccination NN cord-016990-ot1wi3xi 902 47 in in IN cord-016990-ot1wi3xi 902 48 a a DT cord-016990-ot1wi3xi 902 49 child child NN cord-016990-ot1wi3xi 902 50 with with IN cord-016990-ot1wi3xi 902 51 a a DT cord-016990-ot1wi3xi 902 52 congenital congenital JJ cord-016990-ot1wi3xi 902 53 immunodeficiency immunodeficiency NN cord-016990-ot1wi3xi 902 54 Measles Measles NNP cord-016990-ot1wi3xi 902 55 giant giant JJ cord-016990-ot1wi3xi 902 56 cell cell NN cord-016990-ot1wi3xi 902 57 pneumonia pneumonia NN cord-016990-ot1wi3xi 902 58 in in IN cord-016990-ot1wi3xi 902 59 an an DT cord-016990-ot1wi3xi 902 60 adult adult NN cord-016990-ot1wi3xi 902 61 following follow VBG cord-016990-ot1wi3xi 902 62 long long JJ cord-016990-ot1wi3xi 902 63 - - HYPH cord-016990-ot1wi3xi 902 64 term term NN cord-016990-ot1wi3xi 902 65 chemotherapy chemotherapy NN cord-016990-ot1wi3xi 903 1 An an DT cord-016990-ot1wi3xi 903 2 epidemic epidemic NN cord-016990-ot1wi3xi 903 3 of of IN cord-016990-ot1wi3xi 903 4 measles measle NNS cord-016990-ot1wi3xi 903 5 in in IN cord-016990-ot1wi3xi 903 6 southern southern JJ cord-016990-ot1wi3xi 903 7 Greenland Greenland NNP cord-016990-ot1wi3xi 903 8 , , , cord-016990-ot1wi3xi 903 9 1951 1951 CD cord-016990-ot1wi3xi 903 10 ; ; : cord-016990-ot1wi3xi 903 11 measles measle NNS cord-016990-ot1wi3xi 903 12 in in IN cord-016990-ot1wi3xi 903 13 virgin virgin JJ cord-016990-ot1wi3xi 903 14 soil soil NN cord-016990-ot1wi3xi 903 15 . . . cord-016990-ot1wi3xi 904 1 II II NNP cord-016990-ot1wi3xi 904 2 . . . cord-016990-ot1wi3xi 905 1 The the DT cord-016990-ot1wi3xi 905 2 epidemic epidemic NN cord-016990-ot1wi3xi 905 3 proper proper JJ cord-016990-ot1wi3xi 905 4 Human human JJ cord-016990-ot1wi3xi 905 5 membrane membrane NN cord-016990-ot1wi3xi 905 6 cofactor cofactor NN cord-016990-ot1wi3xi 905 7 protein protein NN cord-016990-ot1wi3xi 905 8 ( ( -LRB- cord-016990-ot1wi3xi 905 9 CD46 CD46 NNP cord-016990-ot1wi3xi 905 10 ) ) -RRB- cord-016990-ot1wi3xi 905 11 acts act VBZ cord-016990-ot1wi3xi 905 12 as as IN cord-016990-ot1wi3xi 905 13 a a DT cord-016990-ot1wi3xi 905 14 cellular cellular JJ cord-016990-ot1wi3xi 905 15 receptor receptor NN cord-016990-ot1wi3xi 905 16 for for IN cord-016990-ot1wi3xi 905 17 measles measle NNS cord-016990-ot1wi3xi 905 18 virus virus NN cord-016990-ot1wi3xi 905 19 Viral Viral NNP cord-016990-ot1wi3xi 905 20 Infections infection NNS cord-016990-ot1wi3xi 905 21 of of IN cord-016990-ot1wi3xi 905 22 the the DT cord-016990-ot1wi3xi 905 23 Lung Lung NNP cord-016990-ot1wi3xi 905 24 Measles Measles NNP cord-016990-ot1wi3xi 905 25 virus virus NN cord-016990-ot1wi3xi 905 26 : : : cord-016990-ot1wi3xi 905 27 both both CC cord-016990-ot1wi3xi 905 28 the the DT cord-016990-ot1wi3xi 905 29 haemagglutinin haemagglutinin NNP cord-016990-ot1wi3xi 905 30 and and CC cord-016990-ot1wi3xi 905 31 fusion fusion NN cord-016990-ot1wi3xi 905 32 glycoproteins glycoprotein NNS cord-016990-ot1wi3xi 905 33 are be VBP cord-016990-ot1wi3xi 905 34 required require VBN cord-016990-ot1wi3xi 905 35 for for IN cord-016990-ot1wi3xi 905 36 fusion fusion NN cord-016990-ot1wi3xi 905 37 Measles Measles NNP cord-016990-ot1wi3xi 905 38 : : : cord-016990-ot1wi3xi 905 39 clinical clinical JJ cord-016990-ot1wi3xi 905 40 features feature NNS cord-016990-ot1wi3xi 905 41 . . . cord-016990-ot1wi3xi 906 1 Pathogenesis pathogenesis NN cord-016990-ot1wi3xi 906 2 , , , cord-016990-ot1wi3xi 906 3 pathology pathology NN cord-016990-ot1wi3xi 906 4 and and CC cord-016990-ot1wi3xi 906 5 complications complication NNS cord-016990-ot1wi3xi 906 6 In in IN cord-016990-ot1wi3xi 906 7 vivo vivo NN cord-016990-ot1wi3xi 906 8 and and CC cord-016990-ot1wi3xi 906 9 in in IN cord-016990-ot1wi3xi 906 10 vitro vitro FW cord-016990-ot1wi3xi 906 11 cellular cellular JJ cord-016990-ot1wi3xi 906 12 changes change NNS cord-016990-ot1wi3xi 906 13 specific specific JJ cord-016990-ot1wi3xi 906 14 for for IN cord-016990-ot1wi3xi 906 15 measles measle NNS cord-016990-ot1wi3xi 906 16 Giant giant JJ cord-016990-ot1wi3xi 906 17 - - HYPH cord-016990-ot1wi3xi 906 18 cell cell NN cord-016990-ot1wi3xi 906 19 pneumonia pneumonia NN cord-016990-ot1wi3xi 906 20 caused cause VBN cord-016990-ot1wi3xi 906 21 by by IN cord-016990-ot1wi3xi 906 22 measles measle NNS cord-016990-ot1wi3xi 906 23 and and CC cord-016990-ot1wi3xi 906 24 methotrexate methotrexate NN cord-016990-ot1wi3xi 906 25 in in IN cord-016990-ot1wi3xi 906 26 childhood childhood NN cord-016990-ot1wi3xi 906 27 leukaemia leukaemia NN cord-016990-ot1wi3xi 906 28 in in IN cord-016990-ot1wi3xi 906 29 remission remission NN cord-016990-ot1wi3xi 906 30 Measles Measles NNP cord-016990-ot1wi3xi 906 31 giant giant JJ cord-016990-ot1wi3xi 906 32 cell cell NN cord-016990-ot1wi3xi 906 33 pneumonia pneumonia NN cord-016990-ot1wi3xi 906 34 without without IN cord-016990-ot1wi3xi 906 35 rash rash NN cord-016990-ot1wi3xi 906 36 in in IN cord-016990-ot1wi3xi 906 37 a a DT cord-016990-ot1wi3xi 906 38 case case NN cord-016990-ot1wi3xi 906 39 of of IN cord-016990-ot1wi3xi 906 40 lymphocytic lymphocytic JJ cord-016990-ot1wi3xi 906 41 lymphosarcoma lymphosarcoma NNP cord-016990-ot1wi3xi 906 42 . . . cord-016990-ot1wi3xi 907 1 An an DT cord-016990-ot1wi3xi 907 2 electron electron NN cord-016990-ot1wi3xi 907 3 microscopic microscopic JJ cord-016990-ot1wi3xi 907 4 study study NN cord-016990-ot1wi3xi 907 5 Importance importance NN cord-016990-ot1wi3xi 907 6 of of IN cord-016990-ot1wi3xi 907 7 antibodies antibody NNS cord-016990-ot1wi3xi 907 8 to to IN cord-016990-ot1wi3xi 907 9 the the DT cord-016990-ot1wi3xi 907 10 fusion fusion NN cord-016990-ot1wi3xi 907 11 glycoprotein glycoprotein NN cord-016990-ot1wi3xi 907 12 of of IN cord-016990-ot1wi3xi 907 13 paramyxoviruses paramyxovirus NNS cord-016990-ot1wi3xi 907 14 in in IN cord-016990-ot1wi3xi 907 15 the the DT cord-016990-ot1wi3xi 907 16 prevention prevention NN cord-016990-ot1wi3xi 907 17 of of IN cord-016990-ot1wi3xi 907 18 spread spread NN cord-016990-ot1wi3xi 907 19 of of IN cord-016990-ot1wi3xi 907 20 infection infection NN cord-016990-ot1wi3xi 907 21 Measles Measles NNP cord-016990-ot1wi3xi 907 22 immunization immunization NN cord-016990-ot1wi3xi 907 23 with with IN cord-016990-ot1wi3xi 907 24 killed kill VBN cord-016990-ot1wi3xi 907 25 virus virus NN cord-016990-ot1wi3xi 907 26 vaccine vaccine NN cord-016990-ot1wi3xi 907 27 . . . cord-016990-ot1wi3xi 908 1 Serum serum NN cord-016990-ot1wi3xi 908 2 antibody antibody NN cord-016990-ot1wi3xi 908 3 titers titer NNS cord-016990-ot1wi3xi 908 4 and and CC cord-016990-ot1wi3xi 908 5 experience experience NN cord-016990-ot1wi3xi 908 6 with with IN cord-016990-ot1wi3xi 908 7 exposure exposure NN cord-016990-ot1wi3xi 908 8 to to IN cord-016990-ot1wi3xi 908 9 measles measles NN cord-016990-ot1wi3xi 908 10 epidemic epidemic NN cord-016990-ot1wi3xi 908 11 Altered alter VBN cord-016990-ot1wi3xi 908 12 reactivity reactivity NN cord-016990-ot1wi3xi 908 13 to to IN cord-016990-ot1wi3xi 908 14 measles measle NNS cord-016990-ot1wi3xi 908 15 virus virus NN cord-016990-ot1wi3xi 908 16 . . . cord-016990-ot1wi3xi 909 1 Atypical atypical JJ cord-016990-ot1wi3xi 909 2 measles measle NNS cord-016990-ot1wi3xi 909 3 in in IN cord-016990-ot1wi3xi 909 4 children child NNS cord-016990-ot1wi3xi 909 5 previously previously RB cord-016990-ot1wi3xi 909 6 immunized immunize VBN cord-016990-ot1wi3xi 909 7 with with IN cord-016990-ot1wi3xi 909 8 inactivated inactivate VBN cord-016990-ot1wi3xi 909 9 measles measles NN cord-016990-ot1wi3xi 909 10 virus virus NN cord-016990-ot1wi3xi 909 11 vaccines vaccine VBZ cord-016990-ot1wi3xi 909 12 Pulmonary pulmonary JJ cord-016990-ot1wi3xi 909 13 lesions lesion NNS cord-016990-ot1wi3xi 909 14 in in IN cord-016990-ot1wi3xi 909 15 atypical atypical JJ cord-016990-ot1wi3xi 909 16 measles measle NNS cord-016990-ot1wi3xi 909 17 Difference Difference NNP cord-016990-ot1wi3xi 909 18 in in IN cord-016990-ot1wi3xi 909 19 the the DT cord-016990-ot1wi3xi 909 20 appearance appearance NN cord-016990-ot1wi3xi 909 21 of of IN cord-016990-ot1wi3xi 909 22 antibodies antibody NNS cord-016990-ot1wi3xi 909 23 to to IN cord-016990-ot1wi3xi 909 24 structural structural JJ cord-016990-ot1wi3xi 909 25 components component NNS cord-016990-ot1wi3xi 909 26 of of IN cord-016990-ot1wi3xi 909 27 measles measle NNS cord-016990-ot1wi3xi 909 28 virus virus NN cord-016990-ot1wi3xi 909 29 after after IN cord-016990-ot1wi3xi 909 30 immunization immunization NN cord-016990-ot1wi3xi 909 31 with with IN cord-016990-ot1wi3xi 909 32 inactivated inactivated JJ cord-016990-ot1wi3xi 909 33 and and CC cord-016990-ot1wi3xi 909 34 live live JJ cord-016990-ot1wi3xi 909 35 virus virus NN cord-016990-ot1wi3xi 910 1 The the DT cord-016990-ot1wi3xi 910 2 skin skin NN cord-016990-ot1wi3xi 910 3 lesion lesion NN cord-016990-ot1wi3xi 910 4 in in IN cord-016990-ot1wi3xi 910 5 measles measle NNS cord-016990-ot1wi3xi 910 6 Isolation isolation NN cord-016990-ot1wi3xi 910 7 of of IN cord-016990-ot1wi3xi 910 8 measles measle NNS cord-016990-ot1wi3xi 910 9 virus virus NN cord-016990-ot1wi3xi 910 10 at at IN cord-016990-ot1wi3xi 910 11 autopsy autopsy JJ cord-016990-ot1wi3xi 910 12 in in IN cord-016990-ot1wi3xi 910 13 cases case NNS cord-016990-ot1wi3xi 910 14 of of IN cord-016990-ot1wi3xi 910 15 giant giant JJ cord-016990-ot1wi3xi 910 16 - - HYPH cord-016990-ot1wi3xi 910 17 cell cell NN cord-016990-ot1wi3xi 910 18 pneumonia pneumonia NN cord-016990-ot1wi3xi 910 19 without without IN cord-016990-ot1wi3xi 910 20 rash rash JJ cord-016990-ot1wi3xi 910 21 Patterns pattern NNS cord-016990-ot1wi3xi 910 22 of of IN cord-016990-ot1wi3xi 910 23 measles measle NNS cord-016990-ot1wi3xi 910 24 pneumonitis pneumonitis NN cord-016990-ot1wi3xi 910 25 Fatal fatal JJ cord-016990-ot1wi3xi 910 26 measles measle NNS cord-016990-ot1wi3xi 910 27 ( ( -LRB- cord-016990-ot1wi3xi 910 28 rubeola rubeola NNP cord-016990-ot1wi3xi 910 29 ) ) -RRB- cord-016990-ot1wi3xi 910 30 pneumonia pneumonia NN cord-016990-ot1wi3xi 910 31 in in IN cord-016990-ot1wi3xi 910 32 adults adult NNS cord-016990-ot1wi3xi 911 1 Role role NN cord-016990-ot1wi3xi 911 2 of of IN cord-016990-ot1wi3xi 911 3 measles measle NNS cord-016990-ot1wi3xi 911 4 virus virus NN cord-016990-ot1wi3xi 911 5 in in IN cord-016990-ot1wi3xi 911 6 skin skin NN cord-016990-ot1wi3xi 911 7 lesions lesion NNS cord-016990-ot1wi3xi 911 8 and and CC cord-016990-ot1wi3xi 911 9 Koplik Koplik NNP cord-016990-ot1wi3xi 911 10 's 's POS cord-016990-ot1wi3xi 911 11 spots spot NNS cord-016990-ot1wi3xi 911 12 Pathology Pathology NNP cord-016990-ot1wi3xi 911 13 of of IN cord-016990-ot1wi3xi 911 14 tropical tropical JJ cord-016990-ot1wi3xi 911 15 and and CC cord-016990-ot1wi3xi 911 16 extraordinary extraordinary JJ cord-016990-ot1wi3xi 911 17 diseases disease NNS cord-016990-ot1wi3xi 912 1 The the DT cord-016990-ot1wi3xi 912 2 lungs lung NNS cord-016990-ot1wi3xi 912 3 in in IN cord-016990-ot1wi3xi 912 4 fatal fatal JJ cord-016990-ot1wi3xi 912 5 measles measle NNS cord-016990-ot1wi3xi 912 6 infection infection NN cord-016990-ot1wi3xi 912 7 in in IN cord-016990-ot1wi3xi 912 8 childhood childhood NN cord-016990-ot1wi3xi 912 9 : : : cord-016990-ot1wi3xi 912 10 pathological pathological JJ cord-016990-ot1wi3xi 912 11 , , , cord-016990-ot1wi3xi 912 12 radiological radiological JJ cord-016990-ot1wi3xi 912 13 and and CC cord-016990-ot1wi3xi 912 14 immunological immunological JJ cord-016990-ot1wi3xi 912 15 correlations correlation NNS cord-016990-ot1wi3xi 912 16 Measles Measles NNP cord-016990-ot1wi3xi 912 17 rash rash JJ cord-016990-ot1wi3xi 912 18 . . . cord-016990-ot1wi3xi 913 1 Light light NN cord-016990-ot1wi3xi 913 2 and and CC cord-016990-ot1wi3xi 913 3 electron electron NN cord-016990-ot1wi3xi 913 4 microscopic microscopic JJ cord-016990-ot1wi3xi 913 5 study study NN cord-016990-ot1wi3xi 913 6 of of IN cord-016990-ot1wi3xi 913 7 skin skin NN cord-016990-ot1wi3xi 913 8 eruptions eruption NNS cord-016990-ot1wi3xi 913 9 Atypical atypical JJ cord-016990-ot1wi3xi 913 10 lymphnode lymphnode NN cord-016990-ot1wi3xi 913 11 hyperplasia hyperplasia NN cord-016990-ot1wi3xi 913 12 after after IN cord-016990-ot1wi3xi 913 13 administration administration NN cord-016990-ot1wi3xi 913 14 of of IN cord-016990-ot1wi3xi 913 15 attenuated attenuate VBN cord-016990-ot1wi3xi 913 16 , , , cord-016990-ot1wi3xi 913 17 live live JJ cord-016990-ot1wi3xi 913 18 measles measle NNS cord-016990-ot1wi3xi 913 19 vaccine vaccine NN cord-016990-ot1wi3xi 913 20 Lymphadenopathy lymphadenopathy JJ cord-016990-ot1wi3xi 913 21 simulating simulate VBG cord-016990-ot1wi3xi 913 22 the the DT cord-016990-ot1wi3xi 913 23 malignant malignant JJ cord-016990-ot1wi3xi 913 24 lymphomas lymphoma NNS cord-016990-ot1wi3xi 913 25 Giant giant JJ cord-016990-ot1wi3xi 913 26 cell cell NN cord-016990-ot1wi3xi 913 27 pneumonia pneumonia NN cord-016990-ot1wi3xi 913 28 ; ; : cord-016990-ot1wi3xi 913 29 fluorescent fluorescent JJ cord-016990-ot1wi3xi 913 30 antibody antibody NN cord-016990-ot1wi3xi 913 31 and and CC cord-016990-ot1wi3xi 913 32 histochemical histochemical NNP cord-016990-ot1wi3xi 913 33 studies study NNS cord-016990-ot1wi3xi 913 34 on on IN cord-016990-ot1wi3xi 913 35 alveolar alveolar JJ cord-016990-ot1wi3xi 913 36 giant giant NN cord-016990-ot1wi3xi 913 37 cells cell NNS cord-016990-ot1wi3xi 913 38 Application Application NNP cord-016990-ot1wi3xi 913 39 of of IN cord-016990-ot1wi3xi 913 40 immunofluorescence immunofluorescence NN cord-016990-ot1wi3xi 913 41 to to IN cord-016990-ot1wi3xi 913 42 a a DT cord-016990-ot1wi3xi 913 43 study study NN cord-016990-ot1wi3xi 913 44 of of IN cord-016990-ot1wi3xi 913 45 measles measles NNP cord-016990-ot1wi3xi 913 46 Analysis Analysis NNP cord-016990-ot1wi3xi 913 47 of of IN cord-016990-ot1wi3xi 913 48 viral viral JJ cord-016990-ot1wi3xi 913 49 antigens antigen NNS cord-016990-ot1wi3xi 913 50 in in IN cord-016990-ot1wi3xi 913 51 giant giant JJ cord-016990-ot1wi3xi 913 52 cells cell NNS cord-016990-ot1wi3xi 913 53 of of IN cord-016990-ot1wi3xi 913 54 measles measle NNS cord-016990-ot1wi3xi 913 55 pneumonia pneumonia NN cord-016990-ot1wi3xi 913 56 by by IN cord-016990-ot1wi3xi 913 57 immunoperoxidase immunoperoxidase NN cord-016990-ot1wi3xi 913 58 method method NN cord-016990-ot1wi3xi 913 59 . . . cord-016990-ot1wi3xi 914 1 Virchows Virchows NNP cord-016990-ot1wi3xi 914 2 Arch Arch NNP cord-016990-ot1wi3xi 914 3 A A NNP cord-016990-ot1wi3xi 914 4 Giant giant JJ cord-016990-ot1wi3xi 914 5 cell cell NN cord-016990-ot1wi3xi 914 6 pneumonia pneumonia NN cord-016990-ot1wi3xi 914 7 due due IN cord-016990-ot1wi3xi 914 8 to to IN cord-016990-ot1wi3xi 914 9 respiratory respiratory JJ cord-016990-ot1wi3xi 914 10 syncytial syncytial JJ cord-016990-ot1wi3xi 914 11 virus virus NN cord-016990-ot1wi3xi 914 12 . . . cord-016990-ot1wi3xi 915 1 Occurrence occurrence NN cord-016990-ot1wi3xi 915 2 in in IN cord-016990-ot1wi3xi 915 3 severe severe JJ cord-016990-ot1wi3xi 915 4 combined combine VBN cord-016990-ot1wi3xi 915 5 immunodeficiency immunodeficiency NN cord-016990-ot1wi3xi 915 6 syndrome syndrome NN cord-016990-ot1wi3xi 915 7 Giant giant JJ cord-016990-ot1wi3xi 915 8 cell cell NN cord-016990-ot1wi3xi 915 9 pneumonia pneumonia NN cord-016990-ot1wi3xi 915 10 associated associate VBN cord-016990-ot1wi3xi 915 11 with with IN cord-016990-ot1wi3xi 915 12 parainfluenza parainfluenza NNP cord-016990-ot1wi3xi 915 13 virus virus NNP cord-016990-ot1wi3xi 915 14 type type NN cord-016990-ot1wi3xi 915 15 3 3 CD cord-016990-ot1wi3xi 915 16 infection infection NN cord-016990-ot1wi3xi 915 17 Giant giant JJ cord-016990-ot1wi3xi 915 18 cell cell NN cord-016990-ot1wi3xi 915 19 pneumonia pneumonia NN cord-016990-ot1wi3xi 915 20 caused cause VBN cord-016990-ot1wi3xi 915 21 by by IN cord-016990-ot1wi3xi 915 22 parainfluenza parainfluenza NNP cord-016990-ot1wi3xi 915 23 type type NNP cord-016990-ot1wi3xi 915 24 3 3 CD cord-016990-ot1wi3xi 915 25 in in IN cord-016990-ot1wi3xi 915 26 a a DT cord-016990-ot1wi3xi 915 27 patient patient NN cord-016990-ot1wi3xi 915 28 with with IN cord-016990-ot1wi3xi 915 29 acute acute JJ cord-016990-ot1wi3xi 915 30 myelomonocytic myelomonocytic JJ cord-016990-ot1wi3xi 915 31 leukemia leukemia NN cord-016990-ot1wi3xi 915 32 Giant Giant NNP cord-016990-ot1wi3xi 915 33 cell cell NN cord-016990-ot1wi3xi 915 34 pneumonia pneumonia NN cord-016990-ot1wi3xi 915 35 caused cause VBN cord-016990-ot1wi3xi 915 36 by by IN cord-016990-ot1wi3xi 915 37 varicella varicella NN cord-016990-ot1wi3xi 915 38 zoster zoster NNP cord-016990-ot1wi3xi 915 39 virus virus NN cord-016990-ot1wi3xi 915 40 in in IN cord-016990-ot1wi3xi 915 41 a a DT cord-016990-ot1wi3xi 915 42 neonate neonate NN cord-016990-ot1wi3xi 916 1 A a DT cord-016990-ot1wi3xi 916 2 novel novel JJ cord-016990-ot1wi3xi 916 3 morbilli morbilli NN cord-016990-ot1wi3xi 916 4 virus virus NN cord-016990-ot1wi3xi 916 5 pneumonia pneumonia NN cord-016990-ot1wi3xi 916 6 of of IN cord-016990-ot1wi3xi 916 7 horses horse NNS cord-016990-ot1wi3xi 916 8 and and CC cord-016990-ot1wi3xi 916 9 its -PRON- PRP$ cord-016990-ot1wi3xi 916 10 transmission transmission NN cord-016990-ot1wi3xi 916 11 to to IN cord-016990-ot1wi3xi 916 12 humans human NNS cord-016990-ot1wi3xi 916 13 Use Use NNP cord-016990-ot1wi3xi 916 14 of of IN cord-016990-ot1wi3xi 916 15 immunocytochemistry immunocytochemistry NNP cord-016990-ot1wi3xi 916 16 and and CC cord-016990-ot1wi3xi 916 17 biotinylated biotinylate VBN cord-016990-ot1wi3xi 916 18 in in IN cord-016990-ot1wi3xi 916 19 situ situ JJ cord-016990-ot1wi3xi 916 20 hybridization hybridization NN cord-016990-ot1wi3xi 916 21 for for IN cord-016990-ot1wi3xi 916 22 detecting detect VBG cord-016990-ot1wi3xi 916 23 measles measle NNS cord-016990-ot1wi3xi 916 24 virus virus NN cord-016990-ot1wi3xi 916 25 in in IN cord-016990-ot1wi3xi 916 26 central central JJ cord-016990-ot1wi3xi 916 27 nervous nervous JJ cord-016990-ot1wi3xi 916 28 system system NN cord-016990-ot1wi3xi 916 29 tissue tissue NN cord-016990-ot1wi3xi 916 30 Delayed delay VBD cord-016990-ot1wi3xi 916 31 acute acute JJ cord-016990-ot1wi3xi 916 32 measles measle NNS cord-016990-ot1wi3xi 916 33 inclusion inclusion NN cord-016990-ot1wi3xi 916 34 body body NN cord-016990-ot1wi3xi 916 35 encephalitis encephalitis RB cord-016990-ot1wi3xi 916 36 in in IN cord-016990-ot1wi3xi 916 37 a a DT cord-016990-ot1wi3xi 916 38 9-year 9-year JJ cord-016990-ot1wi3xi 916 39 - - HYPH cord-016990-ot1wi3xi 916 40 old old JJ cord-016990-ot1wi3xi 916 41 girl girl NN cord-016990-ot1wi3xi 916 42 : : : cord-016990-ot1wi3xi 916 43 ultrastructural ultrastructural JJ cord-016990-ot1wi3xi 916 44 , , , cord-016990-ot1wi3xi 916 45 immunohistochemical immunohistochemical JJ cord-016990-ot1wi3xi 916 46 , , , cord-016990-ot1wi3xi 916 47 and and CC cord-016990-ot1wi3xi 916 48 in in IN cord-016990-ot1wi3xi 916 49 situ situ JJ cord-016990-ot1wi3xi 916 50 hybridization hybridization NN cord-016990-ot1wi3xi 916 51 studies study NNS cord-016990-ot1wi3xi 917 1 Baculovirus Baculovirus NNP cord-016990-ot1wi3xi 917 2 expression expression NN cord-016990-ot1wi3xi 917 3 of of IN cord-016990-ot1wi3xi 917 4 the the DT cord-016990-ot1wi3xi 917 5 nucleoprotein nucleoprotein NNP cord-016990-ot1wi3xi 917 6 gene gene NN cord-016990-ot1wi3xi 917 7 of of IN cord-016990-ot1wi3xi 917 8 measles measles NNP cord-016990-ot1wi3xi 917 9 virus virus NN cord-016990-ot1wi3xi 917 10 and and CC cord-016990-ot1wi3xi 917 11 utility utility NN cord-016990-ot1wi3xi 917 12 of of IN cord-016990-ot1wi3xi 917 13 the the DT cord-016990-ot1wi3xi 917 14 recombinant recombinant JJ cord-016990-ot1wi3xi 917 15 protein protein NN cord-016990-ot1wi3xi 917 16 in in IN cord-016990-ot1wi3xi 917 17 diagnostic diagnostic JJ cord-016990-ot1wi3xi 917 18 enzyme enzyme NN cord-016990-ot1wi3xi 917 19 immunoassays immunoassays NNP cord-016990-ot1wi3xi 917 20 Parainfluenza Parainfluenza NNP cord-016990-ot1wi3xi 917 21 viruses virus NNS cord-016990-ot1wi3xi 918 1 Parainfluenza Parainfluenza NNP cord-016990-ot1wi3xi 918 2 viruses virus NNS cord-016990-ot1wi3xi 919 1 Parainfluenza Parainfluenza NNP cord-016990-ot1wi3xi 919 2 virus virus NN cord-016990-ot1wi3xi 919 3 respiratory respiratory JJ cord-016990-ot1wi3xi 919 4 infection infection NN cord-016990-ot1wi3xi 919 5 after after IN cord-016990-ot1wi3xi 919 6 bone bone NN cord-016990-ot1wi3xi 919 7 marrow marrow NN cord-016990-ot1wi3xi 919 8 transplantation transplantation NN cord-016990-ot1wi3xi 919 9 Respiratory respiratory JJ cord-016990-ot1wi3xi 919 10 disease disease NN cord-016990-ot1wi3xi 919 11 due due JJ cord-016990-ot1wi3xi 919 12 to to IN cord-016990-ot1wi3xi 919 13 parainfluenza parainfluenza NNP cord-016990-ot1wi3xi 919 14 virus virus NN cord-016990-ot1wi3xi 919 15 in in IN cord-016990-ot1wi3xi 919 16 adult adult NN cord-016990-ot1wi3xi 919 17 bone bone NN cord-016990-ot1wi3xi 919 18 marrow marrow NN cord-016990-ot1wi3xi 919 19 transplant transplant NN cord-016990-ot1wi3xi 919 20 recipients recipient NNS cord-016990-ot1wi3xi 919 21 Respiratory respiratory JJ cord-016990-ot1wi3xi 919 22 virus virus NN cord-016990-ot1wi3xi 919 23 infections infection NNS cord-016990-ot1wi3xi 919 24 in in IN cord-016990-ot1wi3xi 919 25 bone bone NN cord-016990-ot1wi3xi 919 26 marrow marrow NN cord-016990-ot1wi3xi 919 27 transplant transplant NN cord-016990-ot1wi3xi 919 28 recipients recipient NNS cord-016990-ot1wi3xi 919 29 : : : cord-016990-ot1wi3xi 919 30 the the DT cord-016990-ot1wi3xi 919 31 European european JJ cord-016990-ot1wi3xi 919 32 perspective perspective NN cord-016990-ot1wi3xi 919 33 Respiratory respiratory JJ cord-016990-ot1wi3xi 919 34 viral viral JJ cord-016990-ot1wi3xi 919 35 infections infection NNS cord-016990-ot1wi3xi 919 36 in in IN cord-016990-ot1wi3xi 919 37 lung lung NN cord-016990-ot1wi3xi 919 38 transplant transplant NN cord-016990-ot1wi3xi 919 39 recipients recipient NNS cord-016990-ot1wi3xi 919 40 : : : cord-016990-ot1wi3xi 919 41 radiologic radiologic JJ cord-016990-ot1wi3xi 919 42 findings finding NNS cord-016990-ot1wi3xi 919 43 with with IN cord-016990-ot1wi3xi 919 44 clinical clinical JJ cord-016990-ot1wi3xi 919 45 correlation correlation NN cord-016990-ot1wi3xi 919 46 Outbreak outbreak NN cord-016990-ot1wi3xi 919 47 of of IN cord-016990-ot1wi3xi 919 48 human human JJ cord-016990-ot1wi3xi 919 49 parainfluenza parainfluenza NNP cord-016990-ot1wi3xi 919 50 virus virus NN cord-016990-ot1wi3xi 919 51 3 3 CD cord-016990-ot1wi3xi 919 52 infections infection NNS cord-016990-ot1wi3xi 919 53 in in IN cord-016990-ot1wi3xi 919 54 a a DT cord-016990-ot1wi3xi 919 55 hematopoietic hematopoietic JJ cord-016990-ot1wi3xi 919 56 stem stem NN cord-016990-ot1wi3xi 919 57 cell cell NN cord-016990-ot1wi3xi 919 58 transplant transplant NN cord-016990-ot1wi3xi 919 59 popUlation population NN cord-016990-ot1wi3xi 920 1 Parainfluenza Parainfluenza NNP cord-016990-ot1wi3xi 920 2 virus virus NN cord-016990-ot1wi3xi 920 3 3 3 CD cord-016990-ot1wi3xi 920 4 infection infection NN cord-016990-ot1wi3xi 920 5 after after IN cord-016990-ot1wi3xi 920 6 stem stem NN cord-016990-ot1wi3xi 920 7 cell cell NN cord-016990-ot1wi3xi 920 8 transplant transplant NN cord-016990-ot1wi3xi 920 9 : : : cord-016990-ot1wi3xi 920 10 relevance relevance NN cord-016990-ot1wi3xi 920 11 to to IN cord-016990-ot1wi3xi 920 12 outcome outcome NN cord-016990-ot1wi3xi 920 13 of of IN cord-016990-ot1wi3xi 920 14 rapid rapid JJ cord-016990-ot1wi3xi 920 15 diagnosis diagnosis NN cord-016990-ot1wi3xi 920 16 and and CC cord-016990-ot1wi3xi 920 17 ribavirin ribavirin NN cord-016990-ot1wi3xi 920 18 treatment treatment NN cord-016990-ot1wi3xi 920 19 Pre pre JJ cord-016990-ot1wi3xi 920 20 - - JJ cord-016990-ot1wi3xi 920 21 emptive emptive JJ cord-016990-ot1wi3xi 920 22 oral oral JJ cord-016990-ot1wi3xi 920 23 ribavirin ribavirin NN cord-016990-ot1wi3xi 920 24 therapy therapy NN cord-016990-ot1wi3xi 920 25 of of IN cord-016990-ot1wi3xi 920 26 paramyxovirus paramyxovirus JJ cord-016990-ot1wi3xi 920 27 infections infection NNS cord-016990-ot1wi3xi 920 28 after after IN cord-016990-ot1wi3xi 920 29 haematopoietic haematopoietic JJ cord-016990-ot1wi3xi 920 30 stem stem NN cord-016990-ot1wi3xi 920 31 cell cell NN cord-016990-ot1wi3xi 920 32 transplantation transplantation NN cord-016990-ot1wi3xi 921 1 : : : cord-016990-ot1wi3xi 921 2 a a DT cord-016990-ot1wi3xi 921 3 pilot pilot NN cord-016990-ot1wi3xi 921 4 study study NN cord-016990-ot1wi3xi 921 5 Parainfluenza Parainfluenza NNP cord-016990-ot1wi3xi 921 6 virus virus NN cord-016990-ot1wi3xi 921 7 pneumonitis pneumonitis NN cord-016990-ot1wi3xi 921 8 in in IN cord-016990-ot1wi3xi 921 9 an an DT cord-016990-ot1wi3xi 921 10 adult adult NN cord-016990-ot1wi3xi 921 11 Parainfluenza Parainfluenza NNP cord-016990-ot1wi3xi 921 12 and and CC cord-016990-ot1wi3xi 921 13 influenza influenza NN cord-016990-ot1wi3xi 921 14 virus virus NN cord-016990-ot1wi3xi 921 15 infections infection NNS cord-016990-ot1wi3xi 921 16 in in IN cord-016990-ot1wi3xi 921 17 pediatric pediatric JJ cord-016990-ot1wi3xi 921 18 organ organ NN cord-016990-ot1wi3xi 921 19 transplant transplant NN cord-016990-ot1wi3xi 921 20 recipients recipient NNS cord-016990-ot1wi3xi 921 21 Human Human NNP cord-016990-ot1wi3xi 921 22 parainfluenza parainfluenza NNP cord-016990-ot1wi3xi 921 23 virus virus NN cord-016990-ot1wi3xi 921 24 giant giant JJ cord-016990-ot1wi3xi 921 25 cell cell NN cord-016990-ot1wi3xi 921 26 pneumonia pneumonia NN cord-016990-ot1wi3xi 921 27 following follow VBG cord-016990-ot1wi3xi 921 28 cord cord NN cord-016990-ot1wi3xi 921 29 blood blood NN cord-016990-ot1wi3xi 921 30 transplant transplant NN cord-016990-ot1wi3xi 921 31 associated associate VBN cord-016990-ot1wi3xi 921 32 with with IN cord-016990-ot1wi3xi 921 33 pulmonary pulmonary JJ cord-016990-ot1wi3xi 921 34 alveolar alveolar NN cord-016990-ot1wi3xi 921 35 proteinosis proteinosis NN cord-016990-ot1wi3xi 921 36 Pathology Pathology NNP cord-016990-ot1wi3xi 921 37 of of IN cord-016990-ot1wi3xi 921 38 parainfluenza parainfluenza NNP cord-016990-ot1wi3xi 921 39 virus virus NN cord-016990-ot1wi3xi 921 40 infection infection NN cord-016990-ot1wi3xi 921 41 in in IN cord-016990-ot1wi3xi 921 42 patients patient NNS cord-016990-ot1wi3xi 921 43 with with IN cord-016990-ot1wi3xi 921 44 congenital congenital JJ cord-016990-ot1wi3xi 921 45 immunodeficiency immunodeficiency NN cord-016990-ot1wi3xi 921 46 syndromes syndrome NNS cord-016990-ot1wi3xi 922 1 Parainfluenza Parainfluenza NNP cord-016990-ot1wi3xi 922 2 pneumonia pneumonia NN cord-016990-ot1wi3xi 922 3 in in IN cord-016990-ot1wi3xi 922 4 severe severe JJ cord-016990-ot1wi3xi 922 5 combined combine VBN cord-016990-ot1wi3xi 922 6 immunodeficiency immunodeficiency NN cord-016990-ot1wi3xi 922 7 disease disease NN cord-016990-ot1wi3xi 922 8 Disseminated disseminate VBD cord-016990-ot1wi3xi 922 9 parainfluenza parainfluenza JJ cord-016990-ot1wi3xi 922 10 infection infection NN cord-016990-ot1wi3xi 922 11 in in IN cord-016990-ot1wi3xi 922 12 a a DT cord-016990-ot1wi3xi 922 13 child child NN cord-016990-ot1wi3xi 922 14 with with IN cord-016990-ot1wi3xi 922 15 severe severe JJ cord-016990-ot1wi3xi 922 16 combined combine VBN cord-016990-ot1wi3xi 922 17 immunodeficiency immunodeficiency NN cord-016990-ot1wi3xi 922 18 Observations observation NNS cord-016990-ot1wi3xi 922 19 on on IN cord-016990-ot1wi3xi 922 20 clinical clinical JJ cord-016990-ot1wi3xi 922 21 and and CC cord-016990-ot1wi3xi 922 22 immunofluorescent immunofluorescent JJ cord-016990-ot1wi3xi 922 23 diagnosis diagnosis NN cord-016990-ot1wi3xi 922 24 of of IN cord-016990-ot1wi3xi 922 25 parainfluenza parainfluenza NNP cord-016990-ot1wi3xi 922 26 virus virus NN cord-016990-ot1wi3xi 922 27 infections infection NNS cord-016990-ot1wi3xi 922 28 Parainfluenza Parainfluenza NNP cord-016990-ot1wi3xi 922 29 virus virus NN cord-016990-ot1wi3xi 922 30 bronchiolitis bronchiolitis NN cord-016990-ot1wi3xi 922 31 . . . cord-016990-ot1wi3xi 923 1 Epidemiology epidemiology NN cord-016990-ot1wi3xi 923 2 and and CC cord-016990-ot1wi3xi 923 3 pathogenesis pathogenesis NN cord-016990-ot1wi3xi 923 4 Production production NN cord-016990-ot1wi3xi 923 5 of of IN cord-016990-ot1wi3xi 923 6 monoclonal monoclonal JJ cord-016990-ot1wi3xi 923 7 antibodies antibody NNS cord-016990-ot1wi3xi 923 8 against against IN cord-016990-ot1wi3xi 923 9 parainfluenza parainfluenza NNP cord-016990-ot1wi3xi 923 10 3 3 CD cord-016990-ot1wi3xi 923 11 virus virus NN cord-016990-ot1wi3xi 923 12 and and CC cord-016990-ot1wi3xi 923 13 their -PRON- PRP$ cord-016990-ot1wi3xi 923 14 use use NN cord-016990-ot1wi3xi 923 15 in in IN cord-016990-ot1wi3xi 923 16 diagnosis diagnosis NN cord-016990-ot1wi3xi 923 17 by by IN cord-016990-ot1wi3xi 923 18 immunofluorescence immunofluorescence NN cord-016990-ot1wi3xi 923 19 Comparison comparison NN cord-016990-ot1wi3xi 923 20 of of IN cord-016990-ot1wi3xi 923 21 direct direct JJ cord-016990-ot1wi3xi 923 22 immunofluorescent immunofluorescent NN cord-016990-ot1wi3xi 923 23 staining staining NN cord-016990-ot1wi3xi 923 24 of of IN cord-016990-ot1wi3xi 923 25 clinical clinical JJ cord-016990-ot1wi3xi 923 26 specimens specimen NNS cord-016990-ot1wi3xi 923 27 for for IN cord-016990-ot1wi3xi 923 28 respiratory respiratory JJ cord-016990-ot1wi3xi 923 29 virus virus NN cord-016990-ot1wi3xi 923 30 antigens antigen NNS cord-016990-ot1wi3xi 923 31 with with IN cord-016990-ot1wi3xi 923 32 conventional conventional JJ cord-016990-ot1wi3xi 923 33 isolation isolation NN cord-016990-ot1wi3xi 923 34 techniques technique NNS cord-016990-ot1wi3xi 923 35 Respiratory respiratory JJ cord-016990-ot1wi3xi 923 36 syncytial syncytial JJ cord-016990-ot1wi3xi 923 37 virus virus NN cord-016990-ot1wi3xi 923 38 Respiratory respiratory JJ cord-016990-ot1wi3xi 923 39 syncytial syncytial JJ cord-016990-ot1wi3xi 923 40 virus virus NN cord-016990-ot1wi3xi 923 41 Primary primary JJ cord-016990-ot1wi3xi 923 42 virus virus NN cord-016990-ot1wi3xi 923 43 infection infection NN cord-016990-ot1wi3xi 923 44 with with IN cord-016990-ot1wi3xi 923 45 cytoplasmic cytoplasmic JJ cord-016990-ot1wi3xi 923 46 inclusion inclusion NN cord-016990-ot1wi3xi 923 47 bodies body NNS cord-016990-ot1wi3xi 923 48 . . . cord-016990-ot1wi3xi 924 1 Study study NN cord-016990-ot1wi3xi 924 2 of of IN cord-016990-ot1wi3xi 924 3 an an DT cord-016990-ot1wi3xi 924 4 epidemic epidemic NN cord-016990-ot1wi3xi 924 5 involving involve VBG cord-016990-ot1wi3xi 924 6 thirtytwo thirtytwo NN cord-016990-ot1wi3xi 924 7 infants infant NNS cord-016990-ot1wi3xi 924 8 with with IN cord-016990-ot1wi3xi 924 9 nine nine CD cord-016990-ot1wi3xi 924 10 deaths death NNS cord-016990-ot1wi3xi 924 11 McQuillin McQuillin NNP cord-016990-ot1wi3xi 924 12 1 1 CD cord-016990-ot1wi3xi 924 13 . . . cord-016990-ot1wi3xi 925 1 Pathological pathological JJ cord-016990-ot1wi3xi 925 2 changes change NNS cord-016990-ot1wi3xi 925 3 in in IN cord-016990-ot1wi3xi 925 4 virus virus NN cord-016990-ot1wi3xi 925 5 infections infection NNS cord-016990-ot1wi3xi 925 6 of of IN cord-016990-ot1wi3xi 925 7 the the DT cord-016990-ot1wi3xi 925 8 lower low JJR cord-016990-ot1wi3xi 925 9 respiratory respiratory JJ cord-016990-ot1wi3xi 925 10 tract tract NN cord-016990-ot1wi3xi 925 11 in in IN cord-016990-ot1wi3xi 925 12 children child NNS cord-016990-ot1wi3xi 925 13 Respiratory respiratory JJ cord-016990-ot1wi3xi 925 14 syncytial syncytial JJ cord-016990-ot1wi3xi 925 15 virus virus NN cord-016990-ot1wi3xi 925 16 infection infection NN cord-016990-ot1wi3xi 925 17 in in IN cord-016990-ot1wi3xi 925 18 immunocompromised immunocompromised JJ cord-016990-ot1wi3xi 925 19 adults adult NNS cord-016990-ot1wi3xi 926 1 Neonatal neonatal JJ cord-016990-ot1wi3xi 926 2 respiratory respiratory JJ cord-016990-ot1wi3xi 926 3 syncytial syncytial JJ cord-016990-ot1wi3xi 926 4 virus virus NN cord-016990-ot1wi3xi 926 5 infection infection NN cord-016990-ot1wi3xi 926 6 Fatal fatal JJ cord-016990-ot1wi3xi 926 7 respiratory respiratory JJ cord-016990-ot1wi3xi 926 8 syncytial syncytial JJ cord-016990-ot1wi3xi 926 9 virus virus NN cord-016990-ot1wi3xi 926 10 pneumonitis pneumonitis NN cord-016990-ot1wi3xi 926 11 in in IN cord-016990-ot1wi3xi 926 12 a a DT cord-016990-ot1wi3xi 926 13 previously previously RB cord-016990-ot1wi3xi 926 14 healthy healthy JJ cord-016990-ot1wi3xi 926 15 child child NN cord-016990-ot1wi3xi 926 16 Fatal fatal JJ cord-016990-ot1wi3xi 926 17 pneumonia pneumonia NN cord-016990-ot1wi3xi 926 18 in in IN cord-016990-ot1wi3xi 926 19 an an DT cord-016990-ot1wi3xi 926 20 adult adult NN cord-016990-ot1wi3xi 926 21 due due IN cord-016990-ot1wi3xi 926 22 to to IN cord-016990-ot1wi3xi 926 23 respiratory respiratory JJ cord-016990-ot1wi3xi 926 24 syncytial syncytial JJ cord-016990-ot1wi3xi 926 25 virus virus NN cord-016990-ot1wi3xi 926 26 Demonstration demonstration NN cord-016990-ot1wi3xi 926 27 of of IN cord-016990-ot1wi3xi 926 28 respiratory respiratory JJ cord-016990-ot1wi3xi 926 29 syncytial syncytial JJ cord-016990-ot1wi3xi 926 30 virus virus NN cord-016990-ot1wi3xi 926 31 in in IN cord-016990-ot1wi3xi 926 32 an an DT cord-016990-ot1wi3xi 926 33 autopsy autopsy JJ cord-016990-ot1wi3xi 926 34 series series NN cord-016990-ot1wi3xi 926 35 Pathology pathology NN cord-016990-ot1wi3xi 926 36 of of IN cord-016990-ot1wi3xi 926 37 infectious infectious JJ cord-016990-ot1wi3xi 926 38 diseases disease NNS cord-016990-ot1wi3xi 926 39 Comparison comparison NN cord-016990-ot1wi3xi 926 40 of of IN cord-016990-ot1wi3xi 926 41 cell cell NN cord-016990-ot1wi3xi 926 42 culture culture NN cord-016990-ot1wi3xi 926 43 and and CC cord-016990-ot1wi3xi 926 44 three three CD cord-016990-ot1wi3xi 926 45 enzyme enzyme NN cord-016990-ot1wi3xi 926 46 - - HYPH cord-016990-ot1wi3xi 926 47 linked link VBN cord-016990-ot1wi3xi 926 48 immunosorbent immunosorbent JJ cord-016990-ot1wi3xi 926 49 assays assay NNS cord-016990-ot1wi3xi 926 50 for for IN cord-016990-ot1wi3xi 926 51 the the DT cord-016990-ot1wi3xi 926 52 rapid rapid JJ cord-016990-ot1wi3xi 926 53 diagnosis diagnosis NN cord-016990-ot1wi3xi 926 54 of of IN cord-016990-ot1wi3xi 926 55 respiratory respiratory JJ cord-016990-ot1wi3xi 926 56 syncytial syncytial JJ cord-016990-ot1wi3xi 926 57 virus virus NN cord-016990-ot1wi3xi 926 58 from from IN cord-016990-ot1wi3xi 926 59 nasopharyngeal nasopharyngeal JJ cord-016990-ot1wi3xi 926 60 aspirate aspirate NN cord-016990-ot1wi3xi 926 61 and and CC cord-016990-ot1wi3xi 926 62 tracheal tracheal JJ cord-016990-ot1wi3xi 926 63 secretion secretion NN cord-016990-ot1wi3xi 926 64 specimens specimen NNS cord-016990-ot1wi3xi 926 65 Molecular molecular JJ cord-016990-ot1wi3xi 926 66 detection detection NN cord-016990-ot1wi3xi 926 67 of of IN cord-016990-ot1wi3xi 926 68 respiratory respiratory JJ cord-016990-ot1wi3xi 926 69 syncytial syncytial JJ cord-016990-ot1wi3xi 926 70 virus virus NN cord-016990-ot1wi3xi 926 71 in in IN cord-016990-ot1wi3xi 926 72 postmortem postmortem JJ cord-016990-ot1wi3xi 926 73 lung lung NN cord-016990-ot1wi3xi 926 74 tissue tissue NN cord-016990-ot1wi3xi 926 75 samples sample NNS cord-016990-ot1wi3xi 926 76 from from IN cord-016990-ot1wi3xi 926 77 Mexican mexican JJ cord-016990-ot1wi3xi 926 78 children child NNS cord-016990-ot1wi3xi 926 79 deceased decease VBN cord-016990-ot1wi3xi 926 80 with with IN cord-016990-ot1wi3xi 926 81 pneumonia pneumonia NN cord-016990-ot1wi3xi 926 82 Clinically clinically RB cord-016990-ot1wi3xi 926 83 useful useful JJ cord-016990-ot1wi3xi 926 84 method method NN cord-016990-ot1wi3xi 926 85 for for IN cord-016990-ot1wi3xi 926 86 the the DT cord-016990-ot1wi3xi 926 87 isolation isolation NN cord-016990-ot1wi3xi 926 88 of of IN cord-016990-ot1wi3xi 926 89 respiratory respiratory JJ cord-016990-ot1wi3xi 926 90 syncytial syncytial JJ cord-016990-ot1wi3xi 926 91 virus virus NN cord-016990-ot1wi3xi 926 92 Respiratory respiratory JJ cord-016990-ot1wi3xi 926 93 syncytial syncytial JJ cord-016990-ot1wi3xi 926 94 virus virus NN cord-016990-ot1wi3xi 926 95 infections infection NNS cord-016990-ot1wi3xi 926 96 in in IN cord-016990-ot1wi3xi 926 97 infants infant NNS cord-016990-ot1wi3xi 926 98 : : : cord-016990-ot1wi3xi 926 99 quantitation quantitation NN cord-016990-ot1wi3xi 926 100 and and CC cord-016990-ot1wi3xi 926 101 duration duration NN cord-016990-ot1wi3xi 926 102 of of IN cord-016990-ot1wi3xi 926 103 shedding shed VBG cord-016990-ot1wi3xi 926 104 Viral Viral NNP cord-016990-ot1wi3xi 926 105 Infections Infections NNPS cord-016990-ot1wi3xi 926 106 of of IN cord-016990-ot1wi3xi 926 107 the the DT cord-016990-ot1wi3xi 926 108 Lung Lung NNP cord-016990-ot1wi3xi 926 109 Monoclonal Monoclonal NNP cord-016990-ot1wi3xi 926 110 antibodies antibody NNS cord-016990-ot1wi3xi 926 111 for for IN cord-016990-ot1wi3xi 926 112 the the DT cord-016990-ot1wi3xi 926 113 rapid rapid JJ cord-016990-ot1wi3xi 926 114 diagnosis diagnosis NN cord-016990-ot1wi3xi 926 115 of of IN cord-016990-ot1wi3xi 926 116 respiratory respiratory JJ cord-016990-ot1wi3xi 926 117 syncytial syncytial JJ cord-016990-ot1wi3xi 926 118 virus virus NN cord-016990-ot1wi3xi 926 119 infection infection NN cord-016990-ot1wi3xi 926 120 by by IN cord-016990-ot1wi3xi 926 121 immunofluorescence immunofluorescence NN cord-016990-ot1wi3xi 926 122 Respiratory respiratory JJ cord-016990-ot1wi3xi 926 123 syncytial syncytial JJ cord-016990-ot1wi3xi 926 124 virus virus NN cord-016990-ot1wi3xi 926 125 detection detection NN cord-016990-ot1wi3xi 926 126 by by IN cord-016990-ot1wi3xi 926 127 immunofluorescence immunofluorescence NN cord-016990-ot1wi3xi 926 128 in in IN cord-016990-ot1wi3xi 926 129 nasal nasal JJ cord-016990-ot1wi3xi 926 130 secretions secretion NNS cord-016990-ot1wi3xi 926 131 with with IN cord-016990-ot1wi3xi 926 132 monoclonal monoclonal JJ cord-016990-ot1wi3xi 926 133 antibodies antibody NNS cord-016990-ot1wi3xi 926 134 against against IN cord-016990-ot1wi3xi 926 135 selected select VBN cord-016990-ot1wi3xi 926 136 surface surface NN cord-016990-ot1wi3xi 926 137 and and CC cord-016990-ot1wi3xi 926 138 internal internal JJ cord-016990-ot1wi3xi 926 139 proteins protein NNS cord-016990-ot1wi3xi 926 140 Respiratory respiratory JJ cord-016990-ot1wi3xi 926 141 syncytial syncytial JJ cord-016990-ot1wi3xi 926 142 virus virus NN cord-016990-ot1wi3xi 926 143 illnesses illness NNS cord-016990-ot1wi3xi 926 144 in in IN cord-016990-ot1wi3xi 926 145 human human JJ cord-016990-ot1wi3xi 926 146 immunodeficiency immunodeficiency NN cord-016990-ot1wi3xi 926 147 virusand virusand NNP cord-016990-ot1wi3xi 926 148 noninfected noninfected NNP cord-016990-ot1wi3xi 926 149 children child NNS cord-016990-ot1wi3xi 927 1 A a DT cord-016990-ot1wi3xi 927 2 newly newly RB cord-016990-ot1wi3xi 927 3 discovered discover VBN cord-016990-ot1wi3xi 927 4 human human JJ cord-016990-ot1wi3xi 927 5 pneumovirus pneumovirus NNP cord-016990-ot1wi3xi 927 6 isolated isolate VBN cord-016990-ot1wi3xi 927 7 from from IN cord-016990-ot1wi3xi 927 8 young young JJ cord-016990-ot1wi3xi 927 9 children child NNS cord-016990-ot1wi3xi 927 10 with with IN cord-016990-ot1wi3xi 927 11 respiratory respiratory JJ cord-016990-ot1wi3xi 927 12 tract tract NN cord-016990-ot1wi3xi 927 13 disease disease NN cord-016990-ot1wi3xi 927 14 Prevalence prevalence NN cord-016990-ot1wi3xi 927 15 and and CC cord-016990-ot1wi3xi 927 16 clinical clinical JJ cord-016990-ot1wi3xi 927 17 symptoms symptom NNS cord-016990-ot1wi3xi 927 18 of of IN cord-016990-ot1wi3xi 927 19 human human JJ cord-016990-ot1wi3xi 927 20 metapneumovirus metapneumovirus JJ cord-016990-ot1wi3xi 927 21 infection infection NN cord-016990-ot1wi3xi 927 22 in in IN cord-016990-ot1wi3xi 927 23 hospitalized hospitalize VBN cord-016990-ot1wi3xi 927 24 patients patient NNS cord-016990-ot1wi3xi 927 25 Virological virological JJ cord-016990-ot1wi3xi 927 26 features feature NNS cord-016990-ot1wi3xi 927 27 and and CC cord-016990-ot1wi3xi 927 28 clinical clinical JJ cord-016990-ot1wi3xi 927 29 manifestations manifestation NNS cord-016990-ot1wi3xi 927 30 associated associate VBN cord-016990-ot1wi3xi 927 31 with with IN cord-016990-ot1wi3xi 927 32 human human JJ cord-016990-ot1wi3xi 927 33 metapneumovirus metapneumovirus NNP cord-016990-ot1wi3xi 927 34 : : : cord-016990-ot1wi3xi 927 35 a a DT cord-016990-ot1wi3xi 927 36 new new JJ cord-016990-ot1wi3xi 927 37 paramyxovirus paramyxovirus NN cord-016990-ot1wi3xi 927 38 responsible responsible JJ cord-016990-ot1wi3xi 927 39 for for IN cord-016990-ot1wi3xi 927 40 acute acute JJ cord-016990-ot1wi3xi 927 41 respiratory respiratory JJ cord-016990-ot1wi3xi 927 42 - - HYPH cord-016990-ot1wi3xi 927 43 tract tract NN cord-016990-ot1wi3xi 927 44 infections infection NNS cord-016990-ot1wi3xi 927 45 in in IN cord-016990-ot1wi3xi 927 46 all all DT cord-016990-ot1wi3xi 927 47 age age NN cord-016990-ot1wi3xi 927 48 groups group NNS cord-016990-ot1wi3xi 927 49 Human human JJ cord-016990-ot1wi3xi 927 50 metapneumovirus metapneumovirus JJ cord-016990-ot1wi3xi 927 51 infection infection NN cord-016990-ot1wi3xi 927 52 in in IN cord-016990-ot1wi3xi 927 53 the the DT cord-016990-ot1wi3xi 927 54 United United NNP cord-016990-ot1wi3xi 927 55 States States NNP cord-016990-ot1wi3xi 927 56 : : : cord-016990-ot1wi3xi 927 57 clinical clinical JJ cord-016990-ot1wi3xi 927 58 manifestations manifestation NNS cord-016990-ot1wi3xi 927 59 associated associate VBN cord-016990-ot1wi3xi 927 60 with with IN cord-016990-ot1wi3xi 927 61 a a DT cord-016990-ot1wi3xi 927 62 newly newly RB cord-016990-ot1wi3xi 927 63 emerging emerge VBG cord-016990-ot1wi3xi 927 64 respiratory respiratory JJ cord-016990-ot1wi3xi 927 65 infection infection NN cord-016990-ot1wi3xi 927 66 in in IN cord-016990-ot1wi3xi 927 67 children child NNS cord-016990-ot1wi3xi 927 68 Children child NNS cord-016990-ot1wi3xi 927 69 with with IN cord-016990-ot1wi3xi 927 70 respiratory respiratory JJ cord-016990-ot1wi3xi 927 71 disease disease NN cord-016990-ot1wi3xi 927 72 associated associate VBN cord-016990-ot1wi3xi 927 73 with with IN cord-016990-ot1wi3xi 927 74 metapneumovirus metapneumovirus NNP cord-016990-ot1wi3xi 927 75 in in IN cord-016990-ot1wi3xi 927 76 Hong Hong NNP cord-016990-ot1wi3xi 927 77 Kong Kong NNP cord-016990-ot1wi3xi 927 78 Human Human NNP cord-016990-ot1wi3xi 927 79 metapneumovirus metapneumovirus NN cord-016990-ot1wi3xi 927 80 and and CC cord-016990-ot1wi3xi 927 81 lower low JJR cord-016990-ot1wi3xi 927 82 respiratory respiratory JJ cord-016990-ot1wi3xi 927 83 tract tract NN cord-016990-ot1wi3xi 927 84 disease disease NN cord-016990-ot1wi3xi 927 85 in in IN cord-016990-ot1wi3xi 927 86 otherwise otherwise RB cord-016990-ot1wi3xi 927 87 healthy healthy JJ cord-016990-ot1wi3xi 927 88 infants infant NNS cord-016990-ot1wi3xi 927 89 and and CC cord-016990-ot1wi3xi 927 90 children child NNS cord-016990-ot1wi3xi 928 1 A a DT cord-016990-ot1wi3xi 928 2 prospective prospective JJ cord-016990-ot1wi3xi 928 3 study study NN cord-016990-ot1wi3xi 928 4 comparing compare VBG cord-016990-ot1wi3xi 928 5 human human JJ cord-016990-ot1wi3xi 928 6 metapneumovirus metapneumovirus NN cord-016990-ot1wi3xi 928 7 with with IN cord-016990-ot1wi3xi 928 8 other other JJ cord-016990-ot1wi3xi 928 9 respiratory respiratory JJ cord-016990-ot1wi3xi 928 10 viruses virus NNS cord-016990-ot1wi3xi 928 11 in in IN cord-016990-ot1wi3xi 928 12 adults adult NNS cord-016990-ot1wi3xi 928 13 with with IN cord-016990-ot1wi3xi 928 14 hematologic hematologic JJ cord-016990-ot1wi3xi 928 15 malignancies malignancy NNS cord-016990-ot1wi3xi 928 16 and and CC cord-016990-ot1wi3xi 928 17 respiratory respiratory JJ cord-016990-ot1wi3xi 928 18 tract tract NN cord-016990-ot1wi3xi 928 19 infections infection NNS cord-016990-ot1wi3xi 928 20 Human Human NNP cord-016990-ot1wi3xi 928 21 metapneumovirus metapneumovirus NN cord-016990-ot1wi3xi 928 22 in in IN cord-016990-ot1wi3xi 928 23 a a DT cord-016990-ot1wi3xi 928 24 haematopoietic haematopoietic JJ cord-016990-ot1wi3xi 928 25 stem stem NN cord-016990-ot1wi3xi 928 26 cell cell NN cord-016990-ot1wi3xi 928 27 transplant transplant NN cord-016990-ot1wi3xi 928 28 recipient recipient NN cord-016990-ot1wi3xi 928 29 with with IN cord-016990-ot1wi3xi 928 30 fatal fatal JJ cord-016990-ot1wi3xi 928 31 lower low JJR cord-016990-ot1wi3xi 928 32 respiratory respiratory JJ cord-016990-ot1wi3xi 928 33 tract tract NN cord-016990-ot1wi3xi 928 34 disease disease NN cord-016990-ot1wi3xi 928 35 Respiratory respiratory JJ cord-016990-ot1wi3xi 928 36 tract tract NN cord-016990-ot1wi3xi 928 37 reinfections reinfection NNS cord-016990-ot1wi3xi 928 38 by by IN cord-016990-ot1wi3xi 928 39 the the DT cord-016990-ot1wi3xi 928 40 new new JJ cord-016990-ot1wi3xi 928 41 human human JJ cord-016990-ot1wi3xi 928 42 Metapneumovirus Metapneumovirus NNP cord-016990-ot1wi3xi 928 43 in in IN cord-016990-ot1wi3xi 928 44 an an DT cord-016990-ot1wi3xi 928 45 immunocompromised immunocompromised JJ cord-016990-ot1wi3xi 928 46 child child NN cord-016990-ot1wi3xi 928 47 Experimental experimental JJ cord-016990-ot1wi3xi 928 48 human human JJ cord-016990-ot1wi3xi 928 49 metapneumovirus metapneumovirus NN cord-016990-ot1wi3xi 928 50 infection infection NN cord-016990-ot1wi3xi 928 51 of of IN cord-016990-ot1wi3xi 928 52 cynomolgus cynomolgus JJ cord-016990-ot1wi3xi 928 53 macaques macaque NNS cord-016990-ot1wi3xi 928 54 ( ( -LRB- cord-016990-ot1wi3xi 928 55 Macaca Macaca NNP cord-016990-ot1wi3xi 928 56 fascicularis fascicularis NNP cord-016990-ot1wi3xi 928 57 ) ) -RRB- cord-016990-ot1wi3xi 928 58 results result NNS cord-016990-ot1wi3xi 928 59 in in IN cord-016990-ot1wi3xi 928 60 virus virus NN cord-016990-ot1wi3xi 928 61 replication replication NN cord-016990-ot1wi3xi 928 62 in in IN cord-016990-ot1wi3xi 928 63 ciliated ciliated JJ cord-016990-ot1wi3xi 928 64 epithelial epithelial JJ cord-016990-ot1wi3xi 928 65 cells cell NNS cord-016990-ot1wi3xi 928 66 and and CC cord-016990-ot1wi3xi 928 67 pneumocytes pneumocyte NNS cord-016990-ot1wi3xi 928 68 with with IN cord-016990-ot1wi3xi 928 69 associated associated JJ cord-016990-ot1wi3xi 928 70 lesions lesion NNS cord-016990-ot1wi3xi 928 71 throughout throughout IN cord-016990-ot1wi3xi 928 72 the the DT cord-016990-ot1wi3xi 928 73 respiratory respiratory JJ cord-016990-ot1wi3xi 928 74 tract tract NN cord-016990-ot1wi3xi 928 75 Detection detection NN cord-016990-ot1wi3xi 928 76 of of IN cord-016990-ot1wi3xi 928 77 severe severe JJ cord-016990-ot1wi3xi 928 78 human human JJ cord-016990-ot1wi3xi 928 79 metapneumovirus metapneumovirus NN cord-016990-ot1wi3xi 928 80 infection infection NN cord-016990-ot1wi3xi 928 81 by by IN cord-016990-ot1wi3xi 928 82 real real JJ cord-016990-ot1wi3xi 928 83 - - HYPH cord-016990-ot1wi3xi 928 84 time time NN cord-016990-ot1wi3xi 928 85 473 473 CD cord-016990-ot1wi3xi 928 86 polymerase polymerase NN cord-016990-ot1wi3xi 928 87 chain chain NN cord-016990-ot1wi3xi 928 88 reaction reaction NN cord-016990-ot1wi3xi 928 89 and and CC cord-016990-ot1wi3xi 928 90 histopathological histopathological NNP cord-016990-ot1wi3xi 928 91 assessment assessment NN cord-016990-ot1wi3xi 928 92 McAdam McAdam NNP cord-016990-ot1wi3xi 928 93 Al Al NNP cord-016990-ot1wi3xi 928 94 Pathology Pathology NNP cord-016990-ot1wi3xi 928 95 of of IN cord-016990-ot1wi3xi 928 96 human human JJ cord-016990-ot1wi3xi 928 97 metapneumovirus metapneumovirus JJ cord-016990-ot1wi3xi 928 98 infection infection NN cord-016990-ot1wi3xi 928 99 : : : cord-016990-ot1wi3xi 928 100 insights insight NNS cord-016990-ot1wi3xi 928 101 into into IN cord-016990-ot1wi3xi 928 102 the the DT cord-016990-ot1wi3xi 928 103 pathogenesis pathogenesis NN cord-016990-ot1wi3xi 928 104 of of IN cord-016990-ot1wi3xi 928 105 a a DT cord-016990-ot1wi3xi 928 106 newly newly RB cord-016990-ot1wi3xi 928 107 identified identify VBN cord-016990-ot1wi3xi 928 108 respiratory respiratory JJ cord-016990-ot1wi3xi 928 109 virus virus NN cord-016990-ot1wi3xi 928 110 Human human JJ cord-016990-ot1wi3xi 928 111 metapneumovirusassociated metapneumovirusassociate VBD cord-016990-ot1wi3xi 928 112 atypical atypical JJ cord-016990-ot1wi3xi 928 113 pneumonia pneumonia NN cord-016990-ot1wi3xi 928 114 and and CC cord-016990-ot1wi3xi 928 115 SARS SARS NNP cord-016990-ot1wi3xi 928 116 From from IN cord-016990-ot1wi3xi 928 117 the the DT cord-016990-ot1wi3xi 928 118 Centers Centers NNPS cord-016990-ot1wi3xi 928 119 for for IN cord-016990-ot1wi3xi 928 120 Disease Disease NNP cord-016990-ot1wi3xi 928 121 Control Control NNP cord-016990-ot1wi3xi 928 122 and and CC cord-016990-ot1wi3xi 928 123 Prevention Prevention NNP cord-016990-ot1wi3xi 928 124 . . . cord-016990-ot1wi3xi 929 1 Outbreak outbreak NN cord-016990-ot1wi3xi 929 2 of of IN cord-016990-ot1wi3xi 929 3 Hendra Hendra NNP cord-016990-ot1wi3xi 929 4 - - HYPH cord-016990-ot1wi3xi 929 5 like like JJ cord-016990-ot1wi3xi 929 6 virus virus NN cord-016990-ot1wi3xi 929 7 - - : cord-016990-ot1wi3xi 929 8 Malaysia Malaysia NNP cord-016990-ot1wi3xi 929 9 and and CC cord-016990-ot1wi3xi 929 10 Singapore Singapore NNP cord-016990-ot1wi3xi 929 11 , , , cord-016990-ot1wi3xi 929 12 1998 1998 CD cord-016990-ot1wi3xi 929 13 - - SYM cord-016990-ot1wi3xi 929 14 1999 1999 CD cord-016990-ot1wi3xi 929 15 Fatal Fatal NNP cord-016990-ot1wi3xi 929 16 encephalitis encephalitis RB cord-016990-ot1wi3xi 929 17 due due IN cord-016990-ot1wi3xi 929 18 to to IN cord-016990-ot1wi3xi 929 19 Nipah Nipah NNP cord-016990-ot1wi3xi 929 20 virus virus NN cord-016990-ot1wi3xi 929 21 among among IN cord-016990-ot1wi3xi 929 22 pig pig NN cord-016990-ot1wi3xi 929 23 - - HYPH cord-016990-ot1wi3xi 929 24 farmers farmer NNS cord-016990-ot1wi3xi 929 25 in in IN cord-016990-ot1wi3xi 929 26 Malaysia Malaysia NNP cord-016990-ot1wi3xi 929 27 Outbreak Outbreak NNP cord-016990-ot1wi3xi 929 28 of of IN cord-016990-ot1wi3xi 929 29 Nipah Nipah NNP cord-016990-ot1wi3xi 929 30 - - HYPH cord-016990-ot1wi3xi 929 31 virus virus NN cord-016990-ot1wi3xi 929 32 infection infection NN cord-016990-ot1wi3xi 929 33 among among IN cord-016990-ot1wi3xi 929 34 abattoir abattoir NN cord-016990-ot1wi3xi 929 35 workers worker NNS cord-016990-ot1wi3xi 929 36 in in IN cord-016990-ot1wi3xi 929 37 Singapore Singapore NNP cord-016990-ot1wi3xi 929 38 First First NNP cord-016990-ot1wi3xi 929 39 case case NN cord-016990-ot1wi3xi 929 40 of of IN cord-016990-ot1wi3xi 929 41 Nipah Nipah NNP cord-016990-ot1wi3xi 929 42 virus virus NN cord-016990-ot1wi3xi 929 43 encephalitis encephalitis RB cord-016990-ot1wi3xi 929 44 in in IN cord-016990-ot1wi3xi 929 45 Singapore Singapore NNP cord-016990-ot1wi3xi 929 46 Case Case NNP cord-016990-ot1wi3xi 929 47 - - HYPH cord-016990-ot1wi3xi 929 48 control control NN cord-016990-ot1wi3xi 929 49 study study NN cord-016990-ot1wi3xi 929 50 of of IN cord-016990-ot1wi3xi 929 51 risk risk NN cord-016990-ot1wi3xi 929 52 factors factor NNS cord-016990-ot1wi3xi 929 53 for for IN cord-016990-ot1wi3xi 929 54 human human JJ cord-016990-ot1wi3xi 929 55 infection infection NN cord-016990-ot1wi3xi 929 56 with with IN cord-016990-ot1wi3xi 929 57 a a DT cord-016990-ot1wi3xi 929 58 new new JJ cord-016990-ot1wi3xi 929 59 zoonotic zoonotic JJ cord-016990-ot1wi3xi 929 60 para para NNP cord-016990-ot1wi3xi 929 61 myxovirus myxovirus NNP cord-016990-ot1wi3xi 929 62 , , , cord-016990-ot1wi3xi 929 63 Nipah Nipah NNP cord-016990-ot1wi3xi 929 64 virus virus NN cord-016990-ot1wi3xi 929 65 , , , cord-016990-ot1wi3xi 929 66 during during IN cord-016990-ot1wi3xi 929 67 a a DT cord-016990-ot1wi3xi 929 68 1998 1998 CD cord-016990-ot1wi3xi 929 69 - - SYM cord-016990-ot1wi3xi 929 70 1999 1999 CD cord-016990-ot1wi3xi 929 71 outbreak outbreak NN cord-016990-ot1wi3xi 929 72 of of IN cord-016990-ot1wi3xi 929 73 severe severe JJ cord-016990-ot1wi3xi 929 74 encephalitis encephalitis RB cord-016990-ot1wi3xi 929 75 in in IN cord-016990-ot1wi3xi 929 76 Malaysia Malaysia NNP cord-016990-ot1wi3xi 929 77 Clinical clinical JJ cord-016990-ot1wi3xi 929 78 features feature NNS cord-016990-ot1wi3xi 929 79 of of IN cord-016990-ot1wi3xi 929 80 Nipah Nipah NNP cord-016990-ot1wi3xi 929 81 virus virus NN cord-016990-ot1wi3xi 929 82 encephalitis encephalitis RB cord-016990-ot1wi3xi 929 83 among among IN cord-016990-ot1wi3xi 929 84 pig pig NN cord-016990-ot1wi3xi 929 85 farmers farmer NNS cord-016990-ot1wi3xi 929 86 in in IN cord-016990-ot1wi3xi 929 87 Malaysia Malaysia NNP cord-016990-ot1wi3xi 930 1 The the DT cord-016990-ot1wi3xi 930 2 neurological neurological JJ cord-016990-ot1wi3xi 930 3 manifestations manifestation NNS cord-016990-ot1wi3xi 930 4 of of IN cord-016990-ot1wi3xi 930 5 Nipah Nipah NNP cord-016990-ot1wi3xi 930 6 virus virus NN cord-016990-ot1wi3xi 930 7 encephalitis encephalitis RB cord-016990-ot1wi3xi 930 8 , , , cord-016990-ot1wi3xi 930 9 a a DT cord-016990-ot1wi3xi 930 10 novel novel NN cord-016990-ot1wi3xi 930 11 paramyxovirus paramyxovirus NNP cord-016990-ot1wi3xi 930 12 Molecular molecular JJ cord-016990-ot1wi3xi 930 13 characterization characterization NN cord-016990-ot1wi3xi 930 14 of of IN cord-016990-ot1wi3xi 930 15 Nipah Nipah NNP cord-016990-ot1wi3xi 930 16 virus virus NN cord-016990-ot1wi3xi 930 17 , , , cord-016990-ot1wi3xi 930 18 a a DT cord-016990-ot1wi3xi 930 19 newly newly RB cord-016990-ot1wi3xi 930 20 emergent emergent JJ cord-016990-ot1wi3xi 930 21 paramyxovirus paramyxovirus NNP cord-016990-ot1wi3xi 930 22 Nipah Nipah NNP cord-016990-ot1wi3xi 930 23 virus virus NN cord-016990-ot1wi3xi 930 24 encephalitis encephalitis RB cord-016990-ot1wi3xi 931 1 reemergence reemergence NN cord-016990-ot1wi3xi 932 1 Nipah Nipah NNP cord-016990-ot1wi3xi 932 2 virusassociated virusassociate VBD cord-016990-ot1wi3xi 932 3 encephalitis encephalitis JJ cord-016990-ot1wi3xi 932 4 outbreak outbreak NN cord-016990-ot1wi3xi 933 1 Nipah Nipah NNP cord-016990-ot1wi3xi 933 2 virus virus NN cord-016990-ot1wi3xi 933 3 infection infection NN cord-016990-ot1wi3xi 933 4 in in IN cord-016990-ot1wi3xi 933 5 bats bat NNS cord-016990-ot1wi3xi 933 6 ( ( -LRB- cord-016990-ot1wi3xi 933 7 order order NN cord-016990-ot1wi3xi 933 8 Chiroptera Chiroptera NNP cord-016990-ot1wi3xi 933 9 ) ) -RRB- cord-016990-ot1wi3xi 933 10 in in IN cord-016990-ot1wi3xi 933 11 peninsular peninsular JJ cord-016990-ot1wi3xi 933 12 Malaysia Malaysia NNP cord-016990-ot1wi3xi 933 13 Isolation Isolation NNP cord-016990-ot1wi3xi 933 14 of of IN cord-016990-ot1wi3xi 933 15 Hendra Hendra NNP cord-016990-ot1wi3xi 933 16 virus virus NN cord-016990-ot1wi3xi 933 17 from from IN cord-016990-ot1wi3xi 933 18 pteropid pteropid NN cord-016990-ot1wi3xi 933 19 bats bat NNS cord-016990-ot1wi3xi 933 20 : : : cord-016990-ot1wi3xi 933 21 a a DT cord-016990-ot1wi3xi 933 22 natural natural JJ cord-016990-ot1wi3xi 933 23 reservoir reservoir NN cord-016990-ot1wi3xi 933 24 of of IN cord-016990-ot1wi3xi 933 25 Hendra Hendra NNP cord-016990-ot1wi3xi 933 26 virus virus NN cord-016990-ot1wi3xi 933 27 Antibodies Antibodies NNP cord-016990-ot1wi3xi 933 28 to to IN cord-016990-ot1wi3xi 933 29 Nipah Nipah NNP cord-016990-ot1wi3xi 933 30 - - HYPH cord-016990-ot1wi3xi 933 31 like like JJ cord-016990-ot1wi3xi 933 32 virus virus NN cord-016990-ot1wi3xi 933 33 in in IN cord-016990-ot1wi3xi 933 34 bats bat NNS cord-016990-ot1wi3xi 934 1 Nipah Nipah NNP cord-016990-ot1wi3xi 934 2 virus virus NN cord-016990-ot1wi3xi 934 3 in in IN cord-016990-ot1wi3xi 934 4 Lyle Lyle NNP cord-016990-ot1wi3xi 934 5 's 's POS cord-016990-ot1wi3xi 934 6 fiying fiye VBG cord-016990-ot1wi3xi 934 7 foxes fox NNS cord-016990-ot1wi3xi 935 1 The the DT cord-016990-ot1wi3xi 935 2 natural natural JJ cord-016990-ot1wi3xi 935 3 history history NN cord-016990-ot1wi3xi 935 4 of of IN cord-016990-ot1wi3xi 935 5 Hendra Hendra NNP cord-016990-ot1wi3xi 935 6 and and CC cord-016990-ot1wi3xi 935 7 Nipah Nipah NNP cord-016990-ot1wi3xi 935 8 viruses virus NNS cord-016990-ot1wi3xi 936 1 Elucidation elucidation NN cord-016990-ot1wi3xi 936 2 of of IN cord-016990-ot1wi3xi 936 3 Nipah Nipah NNP cord-016990-ot1wi3xi 936 4 virus virus NN cord-016990-ot1wi3xi 936 5 morphogenesis morphogenesis NN cord-016990-ot1wi3xi 936 6 and and CC cord-016990-ot1wi3xi 936 7 replication replication NN cord-016990-ot1wi3xi 936 8 using use VBG cord-016990-ot1wi3xi 936 9 ultrastructural ultrastructural JJ cord-016990-ot1wi3xi 936 10 and and CC cord-016990-ot1wi3xi 936 11 molecular molecular JJ cord-016990-ot1wi3xi 936 12 approaches approach VBZ cord-016990-ot1wi3xi 936 13 Ultrastructure Ultrastructure NNP cord-016990-ot1wi3xi 936 14 of of IN cord-016990-ot1wi3xi 936 15 Hendra Hendra NNP cord-016990-ot1wi3xi 936 16 virus virus NN cord-016990-ot1wi3xi 936 17 and and CC cord-016990-ot1wi3xi 936 18 Nipah Nipah NNP cord-016990-ot1wi3xi 936 19 virus virus NN cord-016990-ot1wi3xi 936 20 within within IN cord-016990-ot1wi3xi 936 21 cultured cultured JJ cord-016990-ot1wi3xi 936 22 cells cell NNS cord-016990-ot1wi3xi 936 23 and and CC cord-016990-ot1wi3xi 936 24 host host NN cord-016990-ot1wi3xi 936 25 animals animal NNS cord-016990-ot1wi3xi 936 26 Infection infection NN cord-016990-ot1wi3xi 936 27 of of IN cord-016990-ot1wi3xi 936 28 humans human NNS cord-016990-ot1wi3xi 936 29 and and CC cord-016990-ot1wi3xi 936 30 horses horse NNS cord-016990-ot1wi3xi 936 31 by by IN cord-016990-ot1wi3xi 936 32 a a DT cord-016990-ot1wi3xi 936 33 newly newly RB cord-016990-ot1wi3xi 936 34 described describe VBN cord-016990-ot1wi3xi 936 35 morbillivirus morbillivirus NNP cord-016990-ot1wi3xi 936 36 Fatal Fatal NNP cord-016990-ot1wi3xi 936 37 encephalitis encephalitis RB cord-016990-ot1wi3xi 936 38 due due JJ cord-016990-ot1wi3xi 936 39 to to IN cord-016990-ot1wi3xi 936 40 novel novel NN cord-016990-ot1wi3xi 936 41 paramyxovirus paramyxovirus NNP cord-016990-ot1wi3xi 936 42 transmitted transmit VBN cord-016990-ot1wi3xi 936 43 from from IN cord-016990-ot1wi3xi 936 44 horses horse NNS cord-016990-ot1wi3xi 937 1 Comparative comparative JJ cord-016990-ot1wi3xi 937 2 pathology pathology NN cord-016990-ot1wi3xi 937 3 of of IN cord-016990-ot1wi3xi 937 4 the the DT cord-016990-ot1wi3xi 937 5 diseases disease NNS cord-016990-ot1wi3xi 937 6 caused cause VBN cord-016990-ot1wi3xi 937 7 by by IN cord-016990-ot1wi3xi 937 8 Hendra Hendra NNP cord-016990-ot1wi3xi 937 9 and and CC cord-016990-ot1wi3xi 937 10 Nipah Nipah NNP cord-016990-ot1wi3xi 937 11 viruses virus NNS cord-016990-ot1wi3xi 938 1 Reactivity reactivity NN cord-016990-ot1wi3xi 938 2 of of IN cord-016990-ot1wi3xi 938 3 anti anti JJ cord-016990-ot1wi3xi 938 4 - - JJ cord-016990-ot1wi3xi 938 5 Nipah Nipah NNP cord-016990-ot1wi3xi 938 6 virus virus NN cord-016990-ot1wi3xi 938 7 monoclonal monoclonal JJ cord-016990-ot1wi3xi 938 8 antibodies antibody NNS cord-016990-ot1wi3xi 938 9 to to IN cord-016990-ot1wi3xi 938 10 formalin formalin NN cord-016990-ot1wi3xi 938 11 - - HYPH cord-016990-ot1wi3xi 938 12 fixed fix VBN cord-016990-ot1wi3xi 938 13 , , , cord-016990-ot1wi3xi 938 14 paraffin paraffin NN cord-016990-ot1wi3xi 938 15 - - HYPH cord-016990-ot1wi3xi 938 16 embedded embed VBN cord-016990-ot1wi3xi 938 17 lung lung NN cord-016990-ot1wi3xi 938 18 tissues tissue NNS cord-016990-ot1wi3xi 938 19 from from IN cord-016990-ot1wi3xi 938 20 experimental experimental JJ cord-016990-ot1wi3xi 938 21 Nipah Nipah NNP cord-016990-ot1wi3xi 938 22 and and CC cord-016990-ot1wi3xi 938 23 Hendra Hendra NNP cord-016990-ot1wi3xi 938 24 virus virus NN cord-016990-ot1wi3xi 938 25 infections infection NNS cord-016990-ot1wi3xi 938 26 Genetic genetic JJ cord-016990-ot1wi3xi 938 27 characterization characterization NN cord-016990-ot1wi3xi 938 28 of of IN cord-016990-ot1wi3xi 938 29 Nipah Nipah NNP cord-016990-ot1wi3xi 938 30 virus virus NN cord-016990-ot1wi3xi 938 31 Development Development NNP cord-016990-ot1wi3xi 938 32 of of IN cord-016990-ot1wi3xi 938 33 a a DT cord-016990-ot1wi3xi 938 34 fluorogenic fluorogenic JJ cord-016990-ot1wi3xi 938 35 RT RT NNP cord-016990-ot1wi3xi 938 36 - - HYPH cord-016990-ot1wi3xi 938 37 PCR PCR NNP cord-016990-ot1wi3xi 938 38 assay assay NN cord-016990-ot1wi3xi 938 39 ( ( -LRB- cord-016990-ot1wi3xi 938 40 TaqMan TaqMan NNP cord-016990-ot1wi3xi 938 41 ) ) -RRB- cord-016990-ot1wi3xi 938 42 for for IN cord-016990-ot1wi3xi 938 43 the the DT cord-016990-ot1wi3xi 938 44 detection detection NN cord-016990-ot1wi3xi 938 45 of of IN cord-016990-ot1wi3xi 938 46 Hendra Hendra NNP cord-016990-ot1wi3xi 938 47 virus virus NN cord-016990-ot1wi3xi 938 48 Specific specific JJ cord-016990-ot1wi3xi 938 49 detection detection NN cord-016990-ot1wi3xi 938 50 of of IN cord-016990-ot1wi3xi 938 51 Nipah Nipah NNP cord-016990-ot1wi3xi 938 52 virus virus NN cord-016990-ot1wi3xi 938 53 using use VBG cord-016990-ot1wi3xi 938 54 real real JJ cord-016990-ot1wi3xi 938 55 - - HYPH cord-016990-ot1wi3xi 938 56 time time NN cord-016990-ot1wi3xi 938 57 RT rt NN cord-016990-ot1wi3xi 938 58 - - HYPH cord-016990-ot1wi3xi 938 59 PCR PCR NNP cord-016990-ot1wi3xi 938 60 ( ( -LRB- cord-016990-ot1wi3xi 938 61 TaqMan TaqMan NNP cord-016990-ot1wi3xi 938 62 ) ) -RRB- cord-016990-ot1wi3xi 938 63 Cloning cloning NN cord-016990-ot1wi3xi 938 64 of of IN cord-016990-ot1wi3xi 938 65 a a DT cord-016990-ot1wi3xi 938 66 human human JJ cord-016990-ot1wi3xi 938 67 parvovirus parvovirus NN cord-016990-ot1wi3xi 938 68 by by IN cord-016990-ot1wi3xi 938 69 molecular molecular JJ cord-016990-ot1wi3xi 938 70 screening screening NN cord-016990-ot1wi3xi 938 71 of of IN cord-016990-ot1wi3xi 938 72 respiratory respiratory JJ cord-016990-ot1wi3xi 938 73 tract tract NN cord-016990-ot1wi3xi 938 74 samples sample NNS cord-016990-ot1wi3xi 938 75 Human human JJ cord-016990-ot1wi3xi 938 76 parvovirus parvovirus NN cord-016990-ot1wi3xi 938 77 B19 B19 NNP cord-016990-ot1wi3xi 938 78 Torok Torok NNP cord-016990-ot1wi3xi 938 79 TI TI NNP cord-016990-ot1wi3xi 938 80 Parvovirus Parvovirus NNP cord-016990-ot1wi3xi 938 81 infections infection NNS cord-016990-ot1wi3xi 938 82 ( ( -LRB- cord-016990-ot1wi3xi 938 83 Erythema Erythema NNP cord-016990-ot1wi3xi 938 84 infectiosum infectiosum NN cord-016990-ot1wi3xi 938 85 ) ) -RRB- cord-016990-ot1wi3xi 938 86 . . . cord-016990-ot1wi3xi 939 1 In in IN cord-016990-ot1wi3xi 939 2 : : : cord-016990-ot1wi3xi 939 3 Wilfert Wilfert NNP cord-016990-ot1wi3xi 939 4 CM CM NNP cord-016990-ot1wi3xi 939 5 Parvovirus Parvovirus NNP cord-016990-ot1wi3xi 939 6 B19 B19 NNP cord-016990-ot1wi3xi 939 7 infection infection NN cord-016990-ot1wi3xi 939 8 of of IN cord-016990-ot1wi3xi 939 9 the the DT cord-016990-ot1wi3xi 939 10 fetus fetus NN cord-016990-ot1wi3xi 939 11 . . . cord-016990-ot1wi3xi 940 1 Histology histology NN cord-016990-ot1wi3xi 940 2 and and CC cord-016990-ot1wi3xi 940 3 in in IN cord-016990-ot1wi3xi 940 4 situ situ JJ cord-016990-ot1wi3xi 940 5 hybridization hybridization NN cord-016990-ot1wi3xi 940 6 Cohen Cohen NNP cord-016990-ot1wi3xi 940 7 BI BI NNP cord-016990-ot1wi3xi 940 8 Human human JJ cord-016990-ot1wi3xi 940 9 parvovirus parvovirus NN cord-016990-ot1wi3xi 940 10 infection infection NN cord-016990-ot1wi3xi 940 11 in in IN cord-016990-ot1wi3xi 940 12 pregnancy pregnancy NN cord-016990-ot1wi3xi 940 13 and and CC cord-016990-ot1wi3xi 940 14 hydrops hydrops NNP cord-016990-ot1wi3xi 940 15 fetalis fetali VBD cord-016990-ot1wi3xi 940 16 Intrauterine intrauterine JJ cord-016990-ot1wi3xi 940 17 infection infection NN cord-016990-ot1wi3xi 940 18 with with IN cord-016990-ot1wi3xi 940 19 human human JJ cord-016990-ot1wi3xi 940 20 parvovirus parvovirus NN cord-016990-ot1wi3xi 940 21 B19 B19 NNP cord-016990-ot1wi3xi 940 22 : : : cord-016990-ot1wi3xi 940 23 a a DT cord-016990-ot1wi3xi 940 24 light light NN cord-016990-ot1wi3xi 940 25 and and CC cord-016990-ot1wi3xi 940 26 electron electron NN cord-016990-ot1wi3xi 940 27 microscopy microscopy NN cord-016990-ot1wi3xi 940 28 study study NN cord-016990-ot1wi3xi 940 29 Morphological morphological JJ cord-016990-ot1wi3xi 940 30 diagnosis diagnosis NN cord-016990-ot1wi3xi 940 31 of of IN cord-016990-ot1wi3xi 940 32 parvovirus parvovirus NN cord-016990-ot1wi3xi 940 33 B19 B19 NNP cord-016990-ot1wi3xi 940 34 infection infection NN cord-016990-ot1wi3xi 940 35 . . . cord-016990-ot1wi3xi 941 1 A a DT cord-016990-ot1wi3xi 941 2 cytopathic cytopathic JJ cord-016990-ot1wi3xi 941 3 effect effect NN cord-016990-ot1wi3xi 941 4 easily easily RB cord-016990-ot1wi3xi 941 5 recognized recognize VBN cord-016990-ot1wi3xi 941 6 in in IN cord-016990-ot1wi3xi 941 7 air air NN cord-016990-ot1wi3xi 941 8 - - HYPH cord-016990-ot1wi3xi 941 9 dried dry VBN cord-016990-ot1wi3xi 941 10 , , , cord-016990-ot1wi3xi 941 11 formalin formalin NN cord-016990-ot1wi3xi 941 12 - - HYPH cord-016990-ot1wi3xi 941 13 fixed fix VBN cord-016990-ot1wi3xi 941 14 bone bone NN cord-016990-ot1wi3xi 941 15 marrow marrow NN cord-016990-ot1wi3xi 941 16 smears smear NNS cord-016990-ot1wi3xi 941 17 stained stain VBN cord-016990-ot1wi3xi 941 18 with with IN cord-016990-ot1wi3xi 941 19 hematoxylin hematoxylin NNP cord-016990-ot1wi3xi 941 20 - - HYPH cord-016990-ot1wi3xi 941 21 eosin eosin NNP cord-016990-ot1wi3xi 941 22 or or CC cord-016990-ot1wi3xi 941 23 Wright Wright NNP cord-016990-ot1wi3xi 941 24 - - HYPH cord-016990-ot1wi3xi 941 25 Giemsa Giemsa NNP cord-016990-ot1wi3xi 941 26 Clinical clinical JJ cord-016990-ot1wi3xi 941 27 and and CC cord-016990-ot1wi3xi 941 28 histopathological histopathological JJ cord-016990-ot1wi3xi 941 29 features feature NNS cord-016990-ot1wi3xi 941 30 of of IN cord-016990-ot1wi3xi 941 31 parvovirus parvovirus NN cord-016990-ot1wi3xi 941 32 B19 B19 NNP cord-016990-ot1wi3xi 941 33 infection infection NN cord-016990-ot1wi3xi 941 34 in in IN cord-016990-ot1wi3xi 941 35 the the DT cord-016990-ot1wi3xi 941 36 human human JJ cord-016990-ot1wi3xi 941 37 fetus fetus NN cord-016990-ot1wi3xi 941 38 Detection detection NN cord-016990-ot1wi3xi 941 39 of of IN cord-016990-ot1wi3xi 941 40 parvovirus parvovirus NN cord-016990-ot1wi3xi 941 41 B19 B19 NNP cord-016990-ot1wi3xi 941 42 DNA dna NN cord-016990-ot1wi3xi 941 43 in in IN cord-016990-ot1wi3xi 941 44 fetal fetal JJ cord-016990-ot1wi3xi 941 45 tissues tissue NNS cord-016990-ot1wi3xi 941 46 by by IN cord-016990-ot1wi3xi 941 47 in in IN cord-016990-ot1wi3xi 941 48 situ situ NN cord-016990-ot1wi3xi 941 49 hybridisation hybridisation NN cord-016990-ot1wi3xi 941 50 and and CC cord-016990-ot1wi3xi 941 51 polymerase polymerase NN cord-016990-ot1wi3xi 941 52 chain chain NN cord-016990-ot1wi3xi 941 53 reaction reaction NN cord-016990-ot1wi3xi 941 54 Immunohistological Immunohistological NNP cord-016990-ot1wi3xi 941 55 detection detection NN cord-016990-ot1wi3xi 941 56 of of IN cord-016990-ot1wi3xi 941 57 human human JJ cord-016990-ot1wi3xi 941 58 parvovirus parvovirus NN cord-016990-ot1wi3xi 941 59 B19 B19 NNP cord-016990-ot1wi3xi 941 60 in in IN cord-016990-ot1wi3xi 941 61 formalin formalin NN cord-016990-ot1wi3xi 941 62 - - HYPH cord-016990-ot1wi3xi 941 63 fixed fix VBN cord-016990-ot1wi3xi 941 64 , , , cord-016990-ot1wi3xi 941 65 paraffin paraffin NN cord-016990-ot1wi3xi 941 66 - - HYPH cord-016990-ot1wi3xi 941 67 embedded embed VBN cord-016990-ot1wi3xi 941 68 tissues tissue NNS cord-016990-ot1wi3xi 942 1 Combined combine VBN cord-016990-ot1wi3xi 942 2 immunocytochemistry immunocytochemistry NN cord-016990-ot1wi3xi 942 3 and and CC cord-016990-ot1wi3xi 942 4 non non JJ cord-016990-ot1wi3xi 942 5 - - JJ cord-016990-ot1wi3xi 942 6 isotopic isotopic JJ cord-016990-ot1wi3xi 942 7 in in IN cord-016990-ot1wi3xi 942 8 situ situ JJ cord-016990-ot1wi3xi 942 9 hybridization hybridization NN cord-016990-ot1wi3xi 942 10 for for IN cord-016990-ot1wi3xi 942 11 the the DT cord-016990-ot1wi3xi 942 12 ultrastructural ultrastructural JJ cord-016990-ot1wi3xi 942 13 investigation investigation NN cord-016990-ot1wi3xi 942 14 of of IN cord-016990-ot1wi3xi 942 15 human human JJ cord-016990-ot1wi3xi 942 16 parvovirus parvovirus NN cord-016990-ot1wi3xi 942 17 B19 B19 NNP cord-016990-ot1wi3xi 942 18 infection infection NN cord-016990-ot1wi3xi 943 1 Intracellular Intracellular NNP cord-016990-ot1wi3xi 943 2 localization localization NN cord-016990-ot1wi3xi 943 3 of of IN cord-016990-ot1wi3xi 943 4 parvovirus parvovirus NN cord-016990-ot1wi3xi 943 5 B19 b19 NN cord-016990-ot1wi3xi 943 6 nucleic nucleic JJ cord-016990-ot1wi3xi 943 7 acid acid NN cord-016990-ot1wi3xi 943 8 at at IN cord-016990-ot1wi3xi 943 9 the the DT cord-016990-ot1wi3xi 943 10 ultrastructural ultrastructural JJ cord-016990-ot1wi3xi 943 11 level level NN cord-016990-ot1wi3xi 943 12 by by IN cord-016990-ot1wi3xi 943 13 in in IN cord-016990-ot1wi3xi 943 14 situ situ NN cord-016990-ot1wi3xi 943 15 hybridization hybridization NN cord-016990-ot1wi3xi 943 16 with with IN cord-016990-ot1wi3xi 943 17 digoxigenin digoxigenin NNP cord-016990-ot1wi3xi 943 18 - - HYPH cord-016990-ot1wi3xi 943 19 labelled label VBN cord-016990-ot1wi3xi 943 20 probes probe NNS cord-016990-ot1wi3xi 943 21 Detection detection NN cord-016990-ot1wi3xi 943 22 of of IN cord-016990-ot1wi3xi 943 23 parvovirus parvovirus NN cord-016990-ot1wi3xi 943 24 B19 B19 NNP cord-016990-ot1wi3xi 943 25 DNA DNA NNP cord-016990-ot1wi3xi 943 26 in in IN cord-016990-ot1wi3xi 943 27 bone bone NN cord-016990-ot1wi3xi 943 28 marrow marrow NN cord-016990-ot1wi3xi 943 29 cells cell NNS cord-016990-ot1wi3xi 943 30 by by IN cord-016990-ot1wi3xi 943 31 chemiluminescence chemiluminescence NN cord-016990-ot1wi3xi 943 32 in in IN cord-016990-ot1wi3xi 943 33 situ situ NN cord-016990-ot1wi3xi 943 34 hybridization hybridization NN cord-016990-ot1wi3xi 944 1 Viral viral JJ cord-016990-ot1wi3xi 944 2 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 944 3 fevers fever NNS cord-016990-ot1wi3xi 945 1 The the DT cord-016990-ot1wi3xi 945 2 pathology pathology NN cord-016990-ot1wi3xi 945 3 of of IN cord-016990-ot1wi3xi 945 4 Lassa Lassa NNP cord-016990-ot1wi3xi 945 5 fever fever NN cord-016990-ot1wi3xi 945 6 Lassa Lassa NNP cord-016990-ot1wi3xi 945 7 virus virus NN cord-016990-ot1wi3xi 945 8 hepatitis hepatitis NN cord-016990-ot1wi3xi 945 9 : : : cord-016990-ot1wi3xi 945 10 a a DT cord-016990-ot1wi3xi 945 11 study study NN cord-016990-ot1wi3xi 945 12 of of IN cord-016990-ot1wi3xi 945 13 fatal fatal JJ cord-016990-ot1wi3xi 945 14 Lassa Lassa NNP cord-016990-ot1wi3xi 945 15 fever fever NN cord-016990-ot1wi3xi 945 16 in in IN cord-016990-ot1wi3xi 945 17 humans human NNS cord-016990-ot1wi3xi 945 18 Pathologic pathologic JJ cord-016990-ot1wi3xi 945 19 and and CC cord-016990-ot1wi3xi 945 20 virologic virologic JJ cord-016990-ot1wi3xi 945 21 study study NN cord-016990-ot1wi3xi 945 22 of of IN cord-016990-ot1wi3xi 945 23 fatal fatal JJ cord-016990-ot1wi3xi 945 24 Lassa Lassa NNP cord-016990-ot1wi3xi 945 25 fever fever NN cord-016990-ot1wi3xi 945 26 in in IN cord-016990-ot1wi3xi 945 27 man man NN cord-016990-ot1wi3xi 945 28 Pathology Pathology NNP cord-016990-ot1wi3xi 945 29 of of IN cord-016990-ot1wi3xi 945 30 12 12 CD cord-016990-ot1wi3xi 945 31 fatal fatal JJ cord-016990-ot1wi3xi 945 32 cases case NNS cord-016990-ot1wi3xi 945 33 of of IN cord-016990-ot1wi3xi 945 34 Argentine argentine JJ cord-016990-ot1wi3xi 945 35 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 945 36 fever fever NN cord-016990-ot1wi3xi 945 37 Bolivian bolivian JJ cord-016990-ot1wi3xi 945 38 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 945 39 fever fever NN cord-016990-ot1wi3xi 945 40 . . . cord-016990-ot1wi3xi 946 1 A a DT cord-016990-ot1wi3xi 946 2 pathologic pathologic JJ cord-016990-ot1wi3xi 946 3 description description NN cord-016990-ot1wi3xi 946 4 Congo Congo NNP cord-016990-ot1wi3xi 946 5 - - HYPH cord-016990-ot1wi3xi 946 6 Crimean crimean JJ cord-016990-ot1wi3xi 946 7 haemorrhagic haemorrhagic JJ cord-016990-ot1wi3xi 946 8 fever fever NN cord-016990-ot1wi3xi 946 9 in in IN cord-016990-ot1wi3xi 946 10 Dubai Dubai NNP cord-016990-ot1wi3xi 946 11 : : : cord-016990-ot1wi3xi 947 1 histopathological histopathological NNP cord-016990-ot1wi3xi 947 2 studies studies NNPS cord-016990-ot1wi3xi 948 1 A a DT cord-016990-ot1wi3xi 948 2 nosocomial nosocomial JJ cord-016990-ot1wi3xi 948 3 outbreak outbreak NN cord-016990-ot1wi3xi 948 4 of of IN cord-016990-ot1wi3xi 948 5 Crimean Crimean NNP cord-016990-ot1wi3xi 948 6 - - HYPH cord-016990-ot1wi3xi 948 7 Congo Congo NNP cord-016990-ot1wi3xi 948 8 haemorrhagic haemorrhagic JJ cord-016990-ot1wi3xi 948 9 fever fever NN cord-016990-ot1wi3xi 948 10 at at IN cord-016990-ot1wi3xi 948 11 Tygerberg Tygerberg NNP cord-016990-ot1wi3xi 948 12 Hospital Hospital NNP cord-016990-ot1wi3xi 948 13 . . . cord-016990-ot1wi3xi 949 1 Part part NN cord-016990-ot1wi3xi 949 2 III III NNP cord-016990-ot1wi3xi 949 3 . . . cord-016990-ot1wi3xi 950 1 Clinical clinical JJ cord-016990-ot1wi3xi 950 2 pathology pathology NN cord-016990-ot1wi3xi 950 3 and and CC cord-016990-ot1wi3xi 950 4 pathogenesis pathogenesis NN cord-016990-ot1wi3xi 950 5 Rift Rift NNP cord-016990-ot1wi3xi 950 6 Valley Valley NNP cord-016990-ot1wi3xi 950 7 Fever Fever NNP cord-016990-ot1wi3xi 950 8 virus virus NN cord-016990-ot1wi3xi 950 9 infections infection NNS cord-016990-ot1wi3xi 950 10 in in IN cord-016990-ot1wi3xi 950 11 Egypt Egypt NNP cord-016990-ot1wi3xi 950 12 : : : cord-016990-ot1wi3xi 950 13 pathological pathological JJ cord-016990-ot1wi3xi 950 14 and and CC cord-016990-ot1wi3xi 950 15 virological virological JJ cord-016990-ot1wi3xi 950 16 findings finding NNS cord-016990-ot1wi3xi 950 17 in in IN cord-016990-ot1wi3xi 950 18 man man NN cord-016990-ot1wi3xi 950 19 Immunohistochemical Immunohistochemical NNP cord-016990-ot1wi3xi 950 20 and and CC cord-016990-ot1wi3xi 950 21 in in IN cord-016990-ot1wi3xi 950 22 situ situ JJ cord-016990-ot1wi3xi 950 23 localization localization NN cord-016990-ot1wi3xi 950 24 of of IN cord-016990-ot1wi3xi 950 25 Crimean Crimean NNP cord-016990-ot1wi3xi 950 26 - - HYPH cord-016990-ot1wi3xi 950 27 Congo Congo NNP cord-016990-ot1wi3xi 950 28 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 950 29 fever fever NN cord-016990-ot1wi3xi 950 30 ( ( -LRB- cord-016990-ot1wi3xi 950 31 CCHF CCHF NNP cord-016990-ot1wi3xi 950 32 ) ) -RRB- cord-016990-ot1wi3xi 950 33 virus virus NN cord-016990-ot1wi3xi 950 34 in in IN cord-016990-ot1wi3xi 950 35 human human JJ cord-016990-ot1wi3xi 950 36 tissues tissue NNS cord-016990-ot1wi3xi 950 37 and and CC cord-016990-ot1wi3xi 950 38 implications implication NNS cord-016990-ot1wi3xi 950 39 for for IN cord-016990-ot1wi3xi 950 40 CCHF CCHF NNP cord-016990-ot1wi3xi 950 41 pathogenesis pathogenesis NN cord-016990-ot1wi3xi 951 1 Strano Strano NNP cord-016990-ot1wi3xi 951 2 Al Al NNP cord-016990-ot1wi3xi 951 3 Yellow Yellow NNP cord-016990-ot1wi3xi 951 4 fever fever NN cord-016990-ot1wi3xi 951 5 Viral Viral NNP cord-016990-ot1wi3xi 951 6 Infections infection NNS cord-016990-ot1wi3xi 951 7 of of IN cord-016990-ot1wi3xi 951 8 the the DT cord-016990-ot1wi3xi 951 9 Lung Lung NNP cord-016990-ot1wi3xi 951 10 Dengue Dengue NNP cord-016990-ot1wi3xi 951 11 haemorrhagic haemorrhagic JJ cord-016990-ot1wi3xi 951 12 fever fever NN cord-016990-ot1wi3xi 951 13 : : : cord-016990-ot1wi3xi 951 14 a a DT cord-016990-ot1wi3xi 951 15 pathological pathological JJ cord-016990-ot1wi3xi 951 16 study study NN cord-016990-ot1wi3xi 951 17 Ultrastructural Ultrastructural NNP cord-016990-ot1wi3xi 951 18 and and CC cord-016990-ot1wi3xi 951 19 immunohistochemical immunohistochemical JJ cord-016990-ot1wi3xi 951 20 studies study NNS cord-016990-ot1wi3xi 951 21 in in IN cord-016990-ot1wi3xi 951 22 five five CD cord-016990-ot1wi3xi 951 23 cases case NNS cord-016990-ot1wi3xi 951 24 of of IN cord-016990-ot1wi3xi 951 25 Argentine argentine JJ cord-016990-ot1wi3xi 951 26 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 951 27 fever fever NN cord-016990-ot1wi3xi 951 28 Venezuelan venezuelan JJ cord-016990-ot1wi3xi 951 29 haemorrhagic haemorrhagic JJ cord-016990-ot1wi3xi 951 30 fever fever NN cord-016990-ot1wi3xi 951 31 Rift Rift NNP cord-016990-ot1wi3xi 951 32 Valley Valley NNP cord-016990-ot1wi3xi 951 33 fever fever NN cord-016990-ot1wi3xi 951 34 affecting affect VBG cord-016990-ot1wi3xi 951 35 humans human NNS cord-016990-ot1wi3xi 951 36 in in IN cord-016990-ot1wi3xi 951 37 South South NNP cord-016990-ot1wi3xi 951 38 Africa Africa NNP cord-016990-ot1wi3xi 951 39 : : : cord-016990-ot1wi3xi 951 40 a a DT cord-016990-ot1wi3xi 951 41 clinicopathological clinicopathological JJ cord-016990-ot1wi3xi 951 42 study study NN cord-016990-ot1wi3xi 951 43 Pathology Pathology NNP cord-016990-ot1wi3xi 951 44 of of IN cord-016990-ot1wi3xi 951 45 Thailand Thailand NNP cord-016990-ot1wi3xi 951 46 haemorrhagic haemorrhagic JJ cord-016990-ot1wi3xi 951 47 fever fever NN cord-016990-ot1wi3xi 951 48 : : : cord-016990-ot1wi3xi 951 49 a a DT cord-016990-ot1wi3xi 951 50 study study NN cord-016990-ot1wi3xi 951 51 of of IN cord-016990-ot1wi3xi 951 52 100 100 CD cord-016990-ot1wi3xi 951 53 autopsy autopsy JJ cord-016990-ot1wi3xi 951 54 cases case NNS cord-016990-ot1wi3xi 951 55 Dengue dengue NN cord-016990-ot1wi3xi 951 56 and and CC cord-016990-ot1wi3xi 951 57 other other JJ cord-016990-ot1wi3xi 951 58 viral viral JJ cord-016990-ot1wi3xi 951 59 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 951 60 fevers fever NNS cord-016990-ot1wi3xi 951 61 Fatal fatal JJ cord-016990-ot1wi3xi 951 62 hemorrhagic hemorrhagic JJ cord-016990-ot1wi3xi 951 63 fever fever NN cord-016990-ot1wi3xi 951 64 caused cause VBN cord-016990-ot1wi3xi 951 65 by by IN cord-016990-ot1wi3xi 951 66 West West NNP cord-016990-ot1wi3xi 951 67 Nile Nile NNP cord-016990-ot1wi3xi 951 68 virus virus NN cord-016990-ot1wi3xi 951 69 in in IN cord-016990-ot1wi3xi 951 70 the the DT cord-016990-ot1wi3xi 951 71 United United NNP cord-016990-ot1wi3xi 951 72 States States NNP cord-016990-ot1wi3xi 951 73 Acknowledgments Acknowledgments NNPS cord-016990-ot1wi3xi 951 74 . . . cord-016990-ot1wi3xi 952 1 The the DT cord-016990-ot1wi3xi 952 2 authors author NNS cord-016990-ot1wi3xi 952 3 gratefully gratefully RB cord-016990-ot1wi3xi 952 4 acknowledge acknowledge VBP cord-016990-ot1wi3xi 952 5 the the DT cord-016990-ot1wi3xi 952 6 invaluable invaluable JJ cord-016990-ot1wi3xi 952 7 assistance assistance NN cord-016990-ot1wi3xi 952 8 of of IN cord-016990-ot1wi3xi 952 9 Gillian Gillian NNP cord-016990-ot1wi3xi 952 10 Genrich Genrich NNP cord-016990-ot1wi3xi 952 11 , , , cord-016990-ot1wi3xi 952 12 of of IN cord-016990-ot1wi3xi 952 13 the the DT cord-016990-ot1wi3xi 952 14 CDC CDC NNP cord-016990-ot1wi3xi 952 15 , , , cord-016990-ot1wi3xi 952 16 for for IN cord-016990-ot1wi3xi 952 17 her -PRON- PRP$ cord-016990-ot1wi3xi 952 18 comments comment NNS cord-016990-ot1wi3xi 952 19 and and CC cord-016990-ot1wi3xi 952 20 help help NN cord-016990-ot1wi3xi 952 21 with with IN cord-016990-ot1wi3xi 952 22 organization organization NN cord-016990-ot1wi3xi 952 23 of of IN cord-016990-ot1wi3xi 952 24 the the DT cord-016990-ot1wi3xi 952 25 references reference NNS cord-016990-ot1wi3xi 952 26 , , , cord-016990-ot1wi3xi 952 27 Cynthia Cynthia NNP cord-016990-ot1wi3xi 952 28 Goldsmith Goldsmith NNP cord-016990-ot1wi3xi 952 29 for for IN cord-016990-ot1wi3xi 952 30 her -PRON- PRP$ cord-016990-ot1wi3xi 952 31 comments comment NNS cord-016990-ot1wi3xi 952 32 , , , cord-016990-ot1wi3xi 952 33 and and CC cord-016990-ot1wi3xi 952 34 Mitesh Mitesh NNP cord-016990-ot1wi3xi 952 35 Patel Patel NNP cord-016990-ot1wi3xi 952 36 , , , cord-016990-ot1wi3xi 952 37 of of IN cord-016990-ot1wi3xi 952 38 the the DT cord-016990-ot1wi3xi 952 39 CDC CDC NNP cord-016990-ot1wi3xi 952 40 , , , cord-016990-ot1wi3xi 952 41 for for IN cord-016990-ot1wi3xi 952 42 his -PRON- PRP$ cord-016990-ot1wi3xi 952 43 help help NN cord-016990-ot1wi3xi 952 44 with with IN cord-016990-ot1wi3xi 952 45 preparation preparation NN cord-016990-ot1wi3xi 952 46 and and CC cord-016990-ot1wi3xi 952 47 assembly assembly NN cord-016990-ot1wi3xi 952 48 of of IN cord-016990-ot1wi3xi 952 49 the the DT cord-016990-ot1wi3xi 952 50 images image NNS cord-016990-ot1wi3xi 952 51 . . .