id sid tid token lemma pos cord-015922-5wwy0m2k 1 1 key key JJ cord-015922-5wwy0m2k 1 2 : : : cord-015922-5wwy0m2k 1 3 cord-015922 cord-015922 NNP cord-015922-5wwy0m2k 1 4 - - HYPH cord-015922-5wwy0m2k 1 5 5wwy0m2k 5wwy0m2k CD cord-015922-5wwy0m2k 1 6 authors author NNS cord-015922-5wwy0m2k 1 7 : : : cord-015922-5wwy0m2k 1 8 Marty Marty NNP cord-015922-5wwy0m2k 1 9 , , , cord-015922-5wwy0m2k 1 10 Francisco Francisco NNP cord-015922-5wwy0m2k 1 11 M. M. NNP cord-015922-5wwy0m2k 1 12 ; ; : cord-015922-5wwy0m2k 1 13 Baden Baden NNP cord-015922-5wwy0m2k 1 14 , , , cord-015922-5wwy0m2k 1 15 Lindsey Lindsey NNP cord-015922-5wwy0m2k 1 16 R. R. NNP cord-015922-5wwy0m2k 1 17 title title NN cord-015922-5wwy0m2k 1 18 : : : cord-015922-5wwy0m2k 1 19 Infection infection NN cord-015922-5wwy0m2k 1 20 in in IN cord-015922-5wwy0m2k 1 21 the the DT cord-015922-5wwy0m2k 1 22 Hematopoietic Hematopoietic NNP cord-015922-5wwy0m2k 1 23 Stem Stem NNP cord-015922-5wwy0m2k 1 24 Cell Cell NNP cord-015922-5wwy0m2k 1 25 Transplant Transplant NNP cord-015922-5wwy0m2k 1 26 Recipient Recipient NNP cord-015922-5wwy0m2k 1 27 date date NN cord-015922-5wwy0m2k 1 28 : : : cord-015922-5wwy0m2k 1 29 2008 2008 CD cord-015922-5wwy0m2k 1 30 journal journal NN cord-015922-5wwy0m2k 1 31 : : : cord-015922-5wwy0m2k 2 1 Hematopoietic Hematopoietic NNP cord-015922-5wwy0m2k 2 2 Stem Stem NNP cord-015922-5wwy0m2k 2 3 Cell cell NN cord-015922-5wwy0m2k 2 4 Transplantation transplantation NN cord-015922-5wwy0m2k 2 5 DOI doi NN cord-015922-5wwy0m2k 2 6 : : : cord-015922-5wwy0m2k 3 1 10.1007/978 10.1007/978 LS cord-015922-5wwy0m2k 3 2 - - HYPH cord-015922-5wwy0m2k 3 3 1 1 CD cord-015922-5wwy0m2k 3 4 - - HYPH cord-015922-5wwy0m2k 3 5 59745 59745 CD cord-015922-5wwy0m2k 3 6 - - HYPH cord-015922-5wwy0m2k 3 7 438 438 CD cord-015922-5wwy0m2k 3 8 - - HYPH cord-015922-5wwy0m2k 3 9 4_19 4_19 CD cord-015922-5wwy0m2k 3 10 sha sha NNP cord-015922-5wwy0m2k 3 11 : : : cord-015922-5wwy0m2k 3 12 08c166a51c492af21571f14789db44b27ebe53ae 08c166a51c492af21571f14789db44b27ebe53ae CD cord-015922-5wwy0m2k 4 1 doc_id doc_id CD cord-015922-5wwy0m2k 4 2 : : : cord-015922-5wwy0m2k 4 3 15922 15922 CD cord-015922-5wwy0m2k 4 4 cord_uid cord_uid NNS cord-015922-5wwy0m2k 4 5 : : : cord-015922-5wwy0m2k 4 6 5wwy0m2k 5wwy0m2k CD cord-015922-5wwy0m2k 5 1 nan nan NNP cord-015922-5wwy0m2k 5 2 There there EX cord-015922-5wwy0m2k 5 3 are be VBP cord-015922-5wwy0m2k 5 4 three three CD cord-015922-5wwy0m2k 5 5 key key JJ cord-015922-5wwy0m2k 5 6 elements element NNS cord-015922-5wwy0m2k 5 7 of of IN cord-015922-5wwy0m2k 5 8 the the DT cord-015922-5wwy0m2k 5 9 HSCT HSCT NNP cord-015922-5wwy0m2k 5 10 procedure procedure NN cord-015922-5wwy0m2k 5 11 that that WDT cord-015922-5wwy0m2k 5 12 determine determine VBP cord-015922-5wwy0m2k 5 13 the the DT cord-015922-5wwy0m2k 5 14 type type NN cord-015922-5wwy0m2k 5 15 and and CC cord-015922-5wwy0m2k 5 16 timing timing NN cord-015922-5wwy0m2k 5 17 of of IN cord-015922-5wwy0m2k 5 18 the the DT cord-015922-5wwy0m2k 5 19 infectious infectious JJ cord-015922-5wwy0m2k 5 20 risk risk NN cord-015922-5wwy0m2k 5 21 profile profile NN cord-015922-5wwy0m2k 5 22 after after IN cord-015922-5wwy0m2k 5 23 transplantation transplantation NN cord-015922-5wwy0m2k 5 24 [ [ -LRB- cord-015922-5wwy0m2k 5 25 1 1 CD cord-015922-5wwy0m2k 5 26 , , , cord-015922-5wwy0m2k 5 27 7 7 CD cord-015922-5wwy0m2k 5 28 ] ] -RRB- cord-015922-5wwy0m2k 5 29 : : : cord-015922-5wwy0m2k 5 30 1 1 CD cord-015922-5wwy0m2k 5 31 , , , cord-015922-5wwy0m2k 5 32 7 7 CD cord-015922-5wwy0m2k 5 33 a. a. NN cord-015922-5wwy0m2k 6 1 The the DT cord-015922-5wwy0m2k 6 2 duration duration NN cord-015922-5wwy0m2k 6 3 of of IN cord-015922-5wwy0m2k 6 4 neutropenia neutropenia NN cord-015922-5wwy0m2k 6 5 and and CC cord-015922-5wwy0m2k 6 6 mucosal mucosal JJ cord-015922-5wwy0m2k 6 7 injury injury NN cord-015922-5wwy0m2k 6 8 which which WDT cord-015922-5wwy0m2k 6 9 is be VBZ cord-015922-5wwy0m2k 6 10 a a DT cord-015922-5wwy0m2k 6 11 function function NN cord-015922-5wwy0m2k 6 12 of of IN cord-015922-5wwy0m2k 6 13 the the DT cord-015922-5wwy0m2k 6 14 conditioning conditioning NN cord-015922-5wwy0m2k 6 15 regimen regimen NN cord-015922-5wwy0m2k 6 16 selected select VBN cord-015922-5wwy0m2k 6 17 ( ( -LRB- cord-015922-5wwy0m2k 6 18 myeloablative myeloablative NNP cord-015922-5wwy0m2k 6 19 or or CC cord-015922-5wwy0m2k 6 20 not not RB cord-015922-5wwy0m2k 6 21 ) ) -RRB- cord-015922-5wwy0m2k 6 22 and and CC cord-015922-5wwy0m2k 6 23 the the DT cord-015922-5wwy0m2k 6 24 stem stem NN cord-015922-5wwy0m2k 6 25 cells cell NNS cord-015922-5wwy0m2k 6 26 ' ' POS cord-015922-5wwy0m2k 6 27 procurement procurement NN cord-015922-5wwy0m2k 6 28 ( ( -LRB- cord-015922-5wwy0m2k 6 29 cord cord NN cord-015922-5wwy0m2k 6 30 or or CC cord-015922-5wwy0m2k 6 31 adult adult NN cord-015922-5wwy0m2k 6 32 ; ; , cord-015922-5wwy0m2k 6 33 peripheral peripheral JJ cord-015922-5wwy0m2k 6 34 or or CC cord-015922-5wwy0m2k 6 35 bone bone NN cord-015922-5wwy0m2k 6 36 marrow marrow NN cord-015922-5wwy0m2k 6 37 acquisition acquisition NN cord-015922-5wwy0m2k 6 38 among among IN cord-015922-5wwy0m2k 6 39 adult adult NN cord-015922-5wwy0m2k 6 40 donors donor NNS cord-015922-5wwy0m2k 6 41 ) ) -RRB- cord-015922-5wwy0m2k 6 42 . . . cord-015922-5wwy0m2k 7 1 b. b. NNP cord-015922-5wwy0m2k 8 1 The the DT cord-015922-5wwy0m2k 8 2 strategy strategy NN cord-015922-5wwy0m2k 8 3 chosen choose VBN cord-015922-5wwy0m2k 8 4 to to TO cord-015922-5wwy0m2k 8 5 prevent prevent VB cord-015922-5wwy0m2k 8 6 GVHD gvhd NN cord-015922-5wwy0m2k 8 7 among among IN cord-015922-5wwy0m2k 8 8 allogeneic allogeneic NN cord-015922-5wwy0m2k 8 9 recipients recipient NNS cord-015922-5wwy0m2k 8 10 . . . cord-015922-5wwy0m2k 9 1 T T NNP cord-015922-5wwy0m2k 9 2 cell cell NN cord-015922-5wwy0m2k 9 3 depletion depletion NN cord-015922-5wwy0m2k 9 4 and and CC cord-015922-5wwy0m2k 9 5 other other JJ cord-015922-5wwy0m2k 9 6 T T NNP cord-015922-5wwy0m2k 9 7 cell cell NN cord-015922-5wwy0m2k 9 8 manipulation manipulation NN cord-015922-5wwy0m2k 9 9 procedures procedure NNS cord-015922-5wwy0m2k 9 10 lead lead VBP cord-015922-5wwy0m2k 9 11 to to IN cord-015922-5wwy0m2k 9 12 delayed delay VBN cord-015922-5wwy0m2k 9 13 recovery recovery NN cord-015922-5wwy0m2k 9 14 of of IN cord-015922-5wwy0m2k 9 15 lymphocyte lymphocyte NN cord-015922-5wwy0m2k 9 16 function function NN cord-015922-5wwy0m2k 9 17 and and CC cord-015922-5wwy0m2k 9 18 provide provide VB cord-015922-5wwy0m2k 9 19 a a DT cord-015922-5wwy0m2k 9 20 specific specific JJ cord-015922-5wwy0m2k 9 21 immune immune JJ cord-015922-5wwy0m2k 9 22 deficiency deficiency NN cord-015922-5wwy0m2k 9 23 profile profile NN cord-015922-5wwy0m2k 9 24 . . . cord-015922-5wwy0m2k 10 1 c. c. NNP cord-015922-5wwy0m2k 11 1 The the DT cord-015922-5wwy0m2k 11 2 occurrence occurrence NN cord-015922-5wwy0m2k 11 3 and and CC cord-015922-5wwy0m2k 11 4 severity severity NN cord-015922-5wwy0m2k 11 5 of of IN cord-015922-5wwy0m2k 11 6 acute acute JJ cord-015922-5wwy0m2k 11 7 and and CC cord-015922-5wwy0m2k 11 8 chronic chronic JJ cord-015922-5wwy0m2k 11 9 GVHD GVHD NNP cord-015922-5wwy0m2k 11 10 and and CC cord-015922-5wwy0m2k 11 11 its -PRON- PRP$ cord-015922-5wwy0m2k 11 12 treatment treatment NN cord-015922-5wwy0m2k 11 13 [ [ -LRB- cord-015922-5wwy0m2k 11 14 1 1 CD cord-015922-5wwy0m2k 11 15 , , , cord-015922-5wwy0m2k 11 16 7 7 CD cord-015922-5wwy0m2k 11 17 ] ] -RRB- cord-015922-5wwy0m2k 11 18 . . . cord-015922-5wwy0m2k 12 1 The the DT cord-015922-5wwy0m2k 12 2 temporal temporal JJ cord-015922-5wwy0m2k 12 3 course course NN cord-015922-5wwy0m2k 12 4 of of IN cord-015922-5wwy0m2k 12 5 infection infection NN cord-015922-5wwy0m2k 12 6 following follow VBG cord-015922-5wwy0m2k 12 7 HSCT HSCT NNP cord-015922-5wwy0m2k 12 8 can can MD cord-015922-5wwy0m2k 12 9 be be VB cord-015922-5wwy0m2k 12 10 divided divide VBN cord-015922-5wwy0m2k 12 11 into into IN cord-015922-5wwy0m2k 12 12 three three CD cord-015922-5wwy0m2k 12 13 time time NN cord-015922-5wwy0m2k 12 14 periods period NNS cord-015922-5wwy0m2k 12 15 ( ( -LRB- cord-015922-5wwy0m2k 12 16 Fig Fig NNP cord-015922-5wwy0m2k 12 17 . . . cord-015922-5wwy0m2k 12 18 19 19 CD cord-015922-5wwy0m2k 12 19 - - SYM cord-015922-5wwy0m2k 12 20 1 1 CD cord-015922-5wwy0m2k 12 21 ) ) -RRB- cord-015922-5wwy0m2k 12 22 [ [ -LRB- cord-015922-5wwy0m2k 12 23 1 1 CD cord-015922-5wwy0m2k 12 24 , , , cord-015922-5wwy0m2k 12 25 3 3 CD cord-015922-5wwy0m2k 12 26 , , , cord-015922-5wwy0m2k 12 27 4 4 CD cord-015922-5wwy0m2k 12 28 , , , cord-015922-5wwy0m2k 12 29 7 7 CD cord-015922-5wwy0m2k 12 30 ] ] -RRB- cord-015922-5wwy0m2k 12 31 : : : cord-015922-5wwy0m2k 12 32 1 1 LS cord-015922-5wwy0m2k 12 33 . . . cord-015922-5wwy0m2k 13 1 Conditioning conditioning NN cord-015922-5wwy0m2k 13 2 to to IN cord-015922-5wwy0m2k 13 3 Engraftment Engraftment NNP cord-015922-5wwy0m2k 14 1 The the DT cord-015922-5wwy0m2k 14 2 duration duration NN cord-015922-5wwy0m2k 14 3 of of IN cord-015922-5wwy0m2k 14 4 this this DT cord-015922-5wwy0m2k 14 5 period period NN cord-015922-5wwy0m2k 14 6 has have VBZ cord-015922-5wwy0m2k 14 7 become become VBN cord-015922-5wwy0m2k 14 8 dynamic dynamic JJ cord-015922-5wwy0m2k 14 9 and and CC cord-015922-5wwy0m2k 14 10 depends depend VBZ cord-015922-5wwy0m2k 14 11 on on IN cord-015922-5wwy0m2k 14 12 the the DT cord-015922-5wwy0m2k 14 13 conditioning conditioning NN cord-015922-5wwy0m2k 14 14 regimen regimen NN cord-015922-5wwy0m2k 14 15 itself -PRON- PRP cord-015922-5wwy0m2k 14 16 , , , cord-015922-5wwy0m2k 14 17 the the DT cord-015922-5wwy0m2k 14 18 source source NN cord-015922-5wwy0m2k 14 19 and and CC cord-015922-5wwy0m2k 14 20 dose dose NN cord-015922-5wwy0m2k 14 21 of of IN cord-015922-5wwy0m2k 14 22 stem stem NN cord-015922-5wwy0m2k 14 23 cells cell NNS cord-015922-5wwy0m2k 14 24 infused infuse VBN cord-015922-5wwy0m2k 14 25 and and CC cord-015922-5wwy0m2k 14 26 whether whether IN cord-015922-5wwy0m2k 14 27 growth growth NN cord-015922-5wwy0m2k 14 28 factors factor NNS cord-015922-5wwy0m2k 14 29 are be VBP cord-015922-5wwy0m2k 14 30 used use VBN cord-015922-5wwy0m2k 14 31 . . . cord-015922-5wwy0m2k 15 1 It -PRON- PRP cord-015922-5wwy0m2k 15 2 usually usually RB cord-015922-5wwy0m2k 15 3 ranges range VBZ cord-015922-5wwy0m2k 15 4 from from IN cord-015922-5wwy0m2k 15 5 five five CD cord-015922-5wwy0m2k 15 6 ( ( -LRB- cord-015922-5wwy0m2k 15 7 with with IN cord-015922-5wwy0m2k 15 8 nonmyeloablative nonmyeloablative JJ cord-015922-5wwy0m2k 15 9 transplants transplant NNS cord-015922-5wwy0m2k 15 10 ) ) -RRB- cord-015922-5wwy0m2k 15 11 to to IN cord-015922-5wwy0m2k 15 12 30 30 CD cord-015922-5wwy0m2k 15 13 days day NNS cord-015922-5wwy0m2k 15 14 ( ( -LRB- cord-015922-5wwy0m2k 15 15 with with IN cord-015922-5wwy0m2k 15 16 bone bone NN cord-015922-5wwy0m2k 15 17 marrow marrow NN cord-015922-5wwy0m2k 15 18 or or CC cord-015922-5wwy0m2k 15 19 umbilical umbilical JJ cord-015922-5wwy0m2k 15 20 cord cord NN cord-015922-5wwy0m2k 15 21 blood blood NN cord-015922-5wwy0m2k 15 22 transplants transplant NNS cord-015922-5wwy0m2k 15 23 ) ) -RRB- cord-015922-5wwy0m2k 15 24 . . . cord-015922-5wwy0m2k 16 1 The the DT cord-015922-5wwy0m2k 16 2 combination combination NN cord-015922-5wwy0m2k 16 3 of of IN cord-015922-5wwy0m2k 16 4 profound profound JJ cord-015922-5wwy0m2k 16 5 granulocytopenia granulocytopenia NNP cord-015922-5wwy0m2k 16 6 and and CC cord-015922-5wwy0m2k 16 7 mucositis mucositis NNP cord-015922-5wwy0m2k 16 8 with with IN cord-015922-5wwy0m2k 16 9 myeloablative myeloablative NNP cord-015922-5wwy0m2k 16 10 conditioning conditioning NN cord-015922-5wwy0m2k 16 11 makes make VBZ cord-015922-5wwy0m2k 16 12 the the DT cord-015922-5wwy0m2k 16 13 patient patient NN cord-015922-5wwy0m2k 16 14 particularly particularly RB cord-015922-5wwy0m2k 16 15 vulnerable vulnerable JJ cord-015922-5wwy0m2k 16 16 to to IN cord-015922-5wwy0m2k 16 17 bacterial bacterial JJ cord-015922-5wwy0m2k 16 18 and and CC cord-015922-5wwy0m2k 16 19 candidal candidal JJ cord-015922-5wwy0m2k 16 20 infections infection NNS cord-015922-5wwy0m2k 16 21 . . . cord-015922-5wwy0m2k 17 1 In in IN cord-015922-5wwy0m2k 17 2 addition addition NN cord-015922-5wwy0m2k 17 3 , , , cord-015922-5wwy0m2k 17 4 infection infection NN cord-015922-5wwy0m2k 17 5 present present JJ cord-015922-5wwy0m2k 17 6 in in IN cord-015922-5wwy0m2k 17 7 the the DT cord-015922-5wwy0m2k 17 8 transplant transplant NN cord-015922-5wwy0m2k 17 9 recipient recipient NN cord-015922-5wwy0m2k 17 10 pre pre JJ cord-015922-5wwy0m2k 17 11 - - NN cord-015922-5wwy0m2k 17 12 transplant transplant NN cord-015922-5wwy0m2k 17 13 may may MD cord-015922-5wwy0m2k 17 14 be be VB cord-015922-5wwy0m2k 17 15 amplified amplify VBN cord-015922-5wwy0m2k 17 16 by by IN cord-015922-5wwy0m2k 17 17 the the DT cord-015922-5wwy0m2k 17 18 granulocytopenic granulocytopenic NNP cord-015922-5wwy0m2k 17 19 state state NN cord-015922-5wwy0m2k 17 20 and and CC cord-015922-5wwy0m2k 17 21 deficiencies deficiency NNS cord-015922-5wwy0m2k 17 22 of of IN cord-015922-5wwy0m2k 17 23 T T NNP cord-015922-5wwy0m2k 17 24 and and CC cord-015922-5wwy0m2k 17 25 B b NN cord-015922-5wwy0m2k 17 26 - - HYPH cord-015922-5wwy0m2k 17 27 cell cell NN cord-015922-5wwy0m2k 17 28 numbers number NNS cord-015922-5wwy0m2k 17 29 and and CC cord-015922-5wwy0m2k 17 30 function function NN cord-015922-5wwy0m2k 17 31 . . . cord-015922-5wwy0m2k 18 1 Thus thus RB cord-015922-5wwy0m2k 18 2 , , , cord-015922-5wwy0m2k 18 3 control control NN cord-015922-5wwy0m2k 18 4 of of IN cord-015922-5wwy0m2k 18 5 pre pre JJ cord-015922-5wwy0m2k 18 6 - - JJ cord-015922-5wwy0m2k 18 7 transplant transplant JJ cord-015922-5wwy0m2k 18 8 infection infection NN cord-015922-5wwy0m2k 18 9 is be VBZ cord-015922-5wwy0m2k 18 10 needed need VBN cord-015922-5wwy0m2k 18 11 before before IN cord-015922-5wwy0m2k 18 12 initiating initiate VBG cord-015922-5wwy0m2k 18 13 the the DT cord-015922-5wwy0m2k 18 14 conditioning conditioning NN cord-015922-5wwy0m2k 18 15 regimen regimen NN cord-015922-5wwy0m2k 18 16 . . . cord-015922-5wwy0m2k 19 1 Prior prior RB cord-015922-5wwy0m2k 19 2 to to IN cord-015922-5wwy0m2k 19 3 engraftment engraftment NN cord-015922-5wwy0m2k 19 4 ( ( -LRB- cord-015922-5wwy0m2k 19 5 both both DT cord-015922-5wwy0m2k 19 6 with with IN cord-015922-5wwy0m2k 19 7 autologous autologous JJ cord-015922-5wwy0m2k 19 8 and and CC cord-015922-5wwy0m2k 19 9 allogeneic allogeneic JJ cord-015922-5wwy0m2k 19 10 transplants transplant NNS cord-015922-5wwy0m2k 19 11 ) ) -RRB- cord-015922-5wwy0m2k 19 12 , , , cord-015922-5wwy0m2k 19 13 approximately approximately RB cord-015922-5wwy0m2k 19 14 50 50 CD cord-015922-5wwy0m2k 19 15 percent percent NN cord-015922-5wwy0m2k 19 16 of of IN cord-015922-5wwy0m2k 19 17 patients patient NNS cord-015922-5wwy0m2k 19 18 will will MD cord-015922-5wwy0m2k 19 19 have have VB cord-015922-5wwy0m2k 19 20 fever fever NN cord-015922-5wwy0m2k 19 21 of of IN cord-015922-5wwy0m2k 19 22 unknown unknown JJ cord-015922-5wwy0m2k 19 23 origin origin NN cord-015922-5wwy0m2k 19 24 , , , cord-015922-5wwy0m2k 19 25 with with IN cord-015922-5wwy0m2k 19 26 bloodstream bloodstream NN cord-015922-5wwy0m2k 19 27 infection infection NN cord-015922-5wwy0m2k 19 28 in in IN cord-015922-5wwy0m2k 19 29 ~12.5 ~12.5 CD cord-015922-5wwy0m2k 19 30 percent percent NN cord-015922-5wwy0m2k 19 31 and and CC cord-015922-5wwy0m2k 19 32 pneumonia pneumonia NN cord-015922-5wwy0m2k 19 33 in in IN cord-015922-5wwy0m2k 19 34 ∼10 ∼10 NNP cord-015922-5wwy0m2k 19 35 percent percent NN cord-015922-5wwy0m2k 19 36 . . . cord-015922-5wwy0m2k 20 1 The the DT cord-015922-5wwy0m2k 20 2 risk risk NN cord-015922-5wwy0m2k 20 3 of of IN cord-015922-5wwy0m2k 20 4 an an DT cord-015922-5wwy0m2k 20 5 invasive invasive JJ cord-015922-5wwy0m2k 20 6 mold mold NN cord-015922-5wwy0m2k 20 7 infection infection NN cord-015922-5wwy0m2k 20 8 is be VBZ cord-015922-5wwy0m2k 20 9 related relate VBN cord-015922-5wwy0m2k 20 10 to to IN cord-015922-5wwy0m2k 20 11 the the DT cord-015922-5wwy0m2k 20 12 duration duration NN cord-015922-5wwy0m2k 20 13 of of IN cord-015922-5wwy0m2k 20 14 neutropenia neutropenia NN cord-015922-5wwy0m2k 20 15 and and CC cord-015922-5wwy0m2k 20 16 the the DT cord-015922-5wwy0m2k 20 17 environmental environmental JJ cord-015922-5wwy0m2k 20 18 strategy strategy NN cord-015922-5wwy0m2k 20 19 used use VBN cord-015922-5wwy0m2k 20 20 in in IN cord-015922-5wwy0m2k 20 21 a a DT cord-015922-5wwy0m2k 20 22 transplant transplant NN cord-015922-5wwy0m2k 20 23 center center NN cord-015922-5wwy0m2k 20 24 . . . cord-015922-5wwy0m2k 21 1 2 2 LS cord-015922-5wwy0m2k 21 2 . . . cord-015922-5wwy0m2k 22 1 Engraftment Engraftment NNP cord-015922-5wwy0m2k 22 2 to to IN cord-015922-5wwy0m2k 22 3 Post Post NNP cord-015922-5wwy0m2k 22 4 - - NNP cord-015922-5wwy0m2k 22 5 Transplant Transplant NNP cord-015922-5wwy0m2k 22 6 Day Day NNP cord-015922-5wwy0m2k 22 7 100 100 CD cord-015922-5wwy0m2k 22 8 During during IN cord-015922-5wwy0m2k 22 9 this this DT cord-015922-5wwy0m2k 22 10 time time NN cord-015922-5wwy0m2k 22 11 period period NN cord-015922-5wwy0m2k 22 12 viral viral JJ cord-015922-5wwy0m2k 22 13 infections infection NNS cord-015922-5wwy0m2k 22 14 , , , cord-015922-5wwy0m2k 22 15 particularly particularly RB cord-015922-5wwy0m2k 22 16 cytomegalovirus cytomegalovirus NNP cord-015922-5wwy0m2k 22 17 ( ( -LRB- cord-015922-5wwy0m2k 22 18 CMV CMV NNP cord-015922-5wwy0m2k 22 19 ) ) -RRB- cord-015922-5wwy0m2k 22 20 and and CC cord-015922-5wwy0m2k 22 21 the the DT cord-015922-5wwy0m2k 22 22 other other JJ cord-015922-5wwy0m2k 22 23 herpes herpes NN cord-015922-5wwy0m2k 22 24 group group NN cord-015922-5wwy0m2k 22 25 viruses virus NNS cord-015922-5wwy0m2k 22 26 , , , cord-015922-5wwy0m2k 22 27 are be VBP cord-015922-5wwy0m2k 22 28 the the DT cord-015922-5wwy0m2k 22 29 major major JJ cord-015922-5wwy0m2k 22 30 concerns concern NNS cord-015922-5wwy0m2k 22 31 . . . cord-015922-5wwy0m2k 23 1 The the DT cord-015922-5wwy0m2k 23 2 occurrence occurrence NN cord-015922-5wwy0m2k 23 3 , , , cord-015922-5wwy0m2k 23 4 severity severity NN cord-015922-5wwy0m2k 23 5 and and CC cord-015922-5wwy0m2k 23 6 treatment treatment NN cord-015922-5wwy0m2k 23 7 modalities modality NNS cord-015922-5wwy0m2k 23 8 selected select VBN cord-015922-5wwy0m2k 23 9 for for IN cord-015922-5wwy0m2k 23 10 acute acute JJ cord-015922-5wwy0m2k 23 11 GVHD GVHD NNP cord-015922-5wwy0m2k 23 12 further further RB cord-015922-5wwy0m2k 23 13 modulates modulate VBZ cord-015922-5wwy0m2k 23 14 and and CC cord-015922-5wwy0m2k 23 15 increases increase VBZ cord-015922-5wwy0m2k 23 16 the the DT cord-015922-5wwy0m2k 23 17 risk risk NN cord-015922-5wwy0m2k 23 18 of of IN cord-015922-5wwy0m2k 23 19 herpesvirus herpesvirus NN cord-015922-5wwy0m2k 23 20 infections infection NNS cord-015922-5wwy0m2k 23 21 , , , cord-015922-5wwy0m2k 23 22 especially especially RB cord-015922-5wwy0m2k 23 23 CMV CMV NNP cord-015922-5wwy0m2k 23 24 and and CC cord-015922-5wwy0m2k 23 25 Epstein Epstein NNP cord-015922-5wwy0m2k 23 26 - - HYPH cord-015922-5wwy0m2k 23 27 Barr Barr NNP cord-015922-5wwy0m2k 23 28 virus virus NN cord-015922-5wwy0m2k 23 29 ( ( -LRB- cord-015922-5wwy0m2k 23 30 EBV EBV NNP cord-015922-5wwy0m2k 23 31 ) ) -RRB- cord-015922-5wwy0m2k 23 32 , , , cord-015922-5wwy0m2k 23 33 and and CC cord-015922-5wwy0m2k 23 34 invasive invasive JJ cord-015922-5wwy0m2k 23 35 mold mold NN cord-015922-5wwy0m2k 23 36 infections infection NNS cord-015922-5wwy0m2k 23 37 [ [ -LRB- cord-015922-5wwy0m2k 23 38 8 8 CD cord-015922-5wwy0m2k 23 39 ] ] -RRB- cord-015922-5wwy0m2k 24 1 [ [ -LRB- cord-015922-5wwy0m2k 24 2 9 9 CD cord-015922-5wwy0m2k 24 3 ] ] -RRB- cord-015922-5wwy0m2k 24 4 [ [ -LRB- cord-015922-5wwy0m2k 24 5 10 10 CD cord-015922-5wwy0m2k 24 6 ] ] -RRB- cord-015922-5wwy0m2k 24 7 [ [ -LRB- cord-015922-5wwy0m2k 24 8 11 11 CD cord-015922-5wwy0m2k 24 9 ] ] -RRB- cord-015922-5wwy0m2k 24 10 . . . cord-015922-5wwy0m2k 25 1 3 3 LS cord-015922-5wwy0m2k 25 2 . . . cord-015922-5wwy0m2k 26 1 More More JJR cord-015922-5wwy0m2k 26 2 than than IN cord-015922-5wwy0m2k 26 3 100 100 CD cord-015922-5wwy0m2k 26 4 Days day NNS cord-015922-5wwy0m2k 26 5 Post Post NNP cord-015922-5wwy0m2k 26 6 - - NN cord-015922-5wwy0m2k 26 7 Transplant transplant NN cord-015922-5wwy0m2k 27 1 In in IN cord-015922-5wwy0m2k 27 2 the the DT cord-015922-5wwy0m2k 27 3 absence absence NN cord-015922-5wwy0m2k 27 4 of of IN cord-015922-5wwy0m2k 27 5 GVHD GVHD NNP cord-015922-5wwy0m2k 27 6 , , , cord-015922-5wwy0m2k 27 7 the the DT cord-015922-5wwy0m2k 27 8 incidence incidence NN cord-015922-5wwy0m2k 27 9 of of IN cord-015922-5wwy0m2k 27 10 infection infection NN cord-015922-5wwy0m2k 27 11 decreases decrease VBZ cord-015922-5wwy0m2k 27 12 significantly significantly RB cord-015922-5wwy0m2k 27 13 , , , cord-015922-5wwy0m2k 27 14 with with IN cord-015922-5wwy0m2k 27 15 varicella varicella NN cord-015922-5wwy0m2k 27 16 zoster zoster NNP cord-015922-5wwy0m2k 27 17 virus virus NN cord-015922-5wwy0m2k 27 18 ( ( -LRB- cord-015922-5wwy0m2k 27 19 VZV VZV NNP cord-015922-5wwy0m2k 27 20 ) ) -RRB- cord-015922-5wwy0m2k 27 21 , , , cord-015922-5wwy0m2k 27 22 Pneumocystis Pneumocystis NNP cord-015922-5wwy0m2k 27 23 jiroveci jiroveci NNP cord-015922-5wwy0m2k 27 24 ( ( -LRB- cord-015922-5wwy0m2k 27 25 formerly formerly RB cord-015922-5wwy0m2k 27 26 carinii carinii FW cord-015922-5wwy0m2k 27 27 ) ) -RRB- cord-015922-5wwy0m2k 27 28 pneumonia pneumonia NN cord-015922-5wwy0m2k 27 29 ( ( -LRB- cord-015922-5wwy0m2k 27 30 PCP PCP NNP cord-015922-5wwy0m2k 27 31 ) ) -RRB- cord-015922-5wwy0m2k 27 32 and and CC cord-015922-5wwy0m2k 27 33 pneumococcal pneumococcal JJ cord-015922-5wwy0m2k 27 34 infection infection NN cord-015922-5wwy0m2k 27 35 being be VBG cord-015922-5wwy0m2k 27 36 the the DT cord-015922-5wwy0m2k 27 37 primary primary JJ cord-015922-5wwy0m2k 27 38 problems problem NNS cord-015922-5wwy0m2k 27 39 of of IN cord-015922-5wwy0m2k 27 40 this this DT cord-015922-5wwy0m2k 27 41 time time NN cord-015922-5wwy0m2k 27 42 period period NN cord-015922-5wwy0m2k 27 43 . . . cord-015922-5wwy0m2k 28 1 Routine routine JJ cord-015922-5wwy0m2k 28 2 use use NN cord-015922-5wwy0m2k 28 3 of of IN cord-015922-5wwy0m2k 28 4 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 28 5 , , , cord-015922-5wwy0m2k 28 6 such such JJ cord-015922-5wwy0m2k 28 7 as as IN cord-015922-5wwy0m2k 28 8 with with IN cord-015922-5wwy0m2k 28 9 trimethoprim trimethoprim NNP cord-015922-5wwy0m2k 28 10 / / SYM cord-015922-5wwy0m2k 28 11 sulfamethoxazole sulfamethoxazole NNP cord-015922-5wwy0m2k 28 12 and and CC cord-015922-5wwy0m2k 28 13 acyclovir acyclovir NNP cord-015922-5wwy0m2k 28 14 , , , cord-015922-5wwy0m2k 28 15 significantly significantly RB cord-015922-5wwy0m2k 28 16 decreases decrease VBZ cord-015922-5wwy0m2k 28 17 the the DT cord-015922-5wwy0m2k 28 18 occurrence occurrence NN cord-015922-5wwy0m2k 28 19 of of IN cord-015922-5wwy0m2k 28 20 PCP PCP NNP cord-015922-5wwy0m2k 28 21 and and CC cord-015922-5wwy0m2k 28 22 herpesvirus herpesvirus NN cord-015922-5wwy0m2k 28 23 infections infection NNS cord-015922-5wwy0m2k 28 24 , , , cord-015922-5wwy0m2k 28 25 respectively respectively RB cord-015922-5wwy0m2k 28 26 . . . cord-015922-5wwy0m2k 29 1 In in IN cord-015922-5wwy0m2k 29 2 addition addition NN cord-015922-5wwy0m2k 29 3 , , , cord-015922-5wwy0m2k 29 4 late late JJ cord-015922-5wwy0m2k 29 5 or or CC cord-015922-5wwy0m2k 29 6 relapsing relapse VBG cord-015922-5wwy0m2k 29 7 CMV CMV NNP cord-015922-5wwy0m2k 29 8 infection infection NN cord-015922-5wwy0m2k 29 9 may may MD cord-015922-5wwy0m2k 29 10 manifest manifest VB cord-015922-5wwy0m2k 29 11 during during IN cord-015922-5wwy0m2k 29 12 this this DT cord-015922-5wwy0m2k 29 13 time time NN cord-015922-5wwy0m2k 29 14 . . . cord-015922-5wwy0m2k 30 1 If if IN cord-015922-5wwy0m2k 30 2 GVHD GVHD NNP cord-015922-5wwy0m2k 30 3 is be VBZ cord-015922-5wwy0m2k 30 4 present present JJ cord-015922-5wwy0m2k 30 5 , , , cord-015922-5wwy0m2k 30 6 it -PRON- PRP cord-015922-5wwy0m2k 30 7 is be VBZ cord-015922-5wwy0m2k 30 8 typically typically RB cord-015922-5wwy0m2k 30 9 treated treat VBN cord-015922-5wwy0m2k 30 10 with with IN cord-015922-5wwy0m2k 30 11 significant significant JJ cord-015922-5wwy0m2k 30 12 augmentation augmentation NN cord-015922-5wwy0m2k 30 13 of of IN cord-015922-5wwy0m2k 30 14 immunosuppressive immunosuppressive JJ cord-015922-5wwy0m2k 30 15 therapy therapy NN cord-015922-5wwy0m2k 30 16 such such JJ cord-015922-5wwy0m2k 30 17 as as IN cord-015922-5wwy0m2k 30 18 with with IN cord-015922-5wwy0m2k 30 19 high high JJ cord-015922-5wwy0m2k 30 20 - - HYPH cord-015922-5wwy0m2k 30 21 dose dose NN cord-015922-5wwy0m2k 30 22 corticosteroids corticosteroid NNS cord-015922-5wwy0m2k 30 23 and and CC cord-015922-5wwy0m2k 30 24 monoclonal monoclonal JJ cord-015922-5wwy0m2k 30 25 antibodies antibody NNS cord-015922-5wwy0m2k 30 26 . . . cord-015922-5wwy0m2k 31 1 Patients patient NNS cord-015922-5wwy0m2k 31 2 in in IN cord-015922-5wwy0m2k 31 3 this this DT cord-015922-5wwy0m2k 31 4 last last JJ cord-015922-5wwy0m2k 31 5 category category NN cord-015922-5wwy0m2k 31 6 ( ( -LRB- cord-015922-5wwy0m2k 31 7 GVHD GVHD NNP cord-015922-5wwy0m2k 31 8 under under IN cord-015922-5wwy0m2k 31 9 treatment treatment NN cord-015922-5wwy0m2k 31 10 ) ) -RRB- cord-015922-5wwy0m2k 31 11 are be VBP cord-015922-5wwy0m2k 31 12 at at IN cord-015922-5wwy0m2k 31 13 particular particular JJ cord-015922-5wwy0m2k 31 14 risk risk NN cord-015922-5wwy0m2k 31 15 for for IN cord-015922-5wwy0m2k 31 16 invasive invasive JJ cord-015922-5wwy0m2k 31 17 mold mold NN cord-015922-5wwy0m2k 31 18 infection infection NN cord-015922-5wwy0m2k 31 19 , , , cord-015922-5wwy0m2k 31 20 CMV CMV NNP cord-015922-5wwy0m2k 31 21 reactivation reactivation NN cord-015922-5wwy0m2k 31 22 , , , cord-015922-5wwy0m2k 31 23 PCP PCP NNP cord-015922-5wwy0m2k 31 24 and and CC cord-015922-5wwy0m2k 31 25 other other JJ cord-015922-5wwy0m2k 31 26 common common JJ cord-015922-5wwy0m2k 31 27 and and CC cord-015922-5wwy0m2k 31 28 opportunistic opportunistic JJ cord-015922-5wwy0m2k 31 29 pathogens pathogen NNS cord-015922-5wwy0m2k 31 30 . . . cord-015922-5wwy0m2k 32 1 There there EX cord-015922-5wwy0m2k 32 2 are be VBP cord-015922-5wwy0m2k 32 3 four four CD cord-015922-5wwy0m2k 32 4 modes mode NNS cord-015922-5wwy0m2k 32 5 in in IN cord-015922-5wwy0m2k 32 6 which which WDT cord-015922-5wwy0m2k 32 7 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 32 8 therapy therapy NN cord-015922-5wwy0m2k 32 9 can can MD cord-015922-5wwy0m2k 32 10 be be VB cord-015922-5wwy0m2k 32 11 administered administer VBN cord-015922-5wwy0m2k 32 12 to to IN cord-015922-5wwy0m2k 32 13 the the DT cord-015922-5wwy0m2k 32 14 HSCT HSCT NNP cord-015922-5wwy0m2k 32 15 patient patient NN cord-015922-5wwy0m2k 32 16 [ [ -LRB- cord-015922-5wwy0m2k 32 17 4 4 CD cord-015922-5wwy0m2k 32 18 ] ] -RRB- cord-015922-5wwy0m2k 32 19 : : : cord-015922-5wwy0m2k 33 1 1 1 LS cord-015922-5wwy0m2k 33 2 . . . cord-015922-5wwy0m2k 34 1 A a DT cord-015922-5wwy0m2k 34 2 therapeutic therapeutic JJ cord-015922-5wwy0m2k 34 3 mode mode NN cord-015922-5wwy0m2k 34 4 , , , cord-015922-5wwy0m2k 34 5 in in IN cord-015922-5wwy0m2k 34 6 which which WDT cord-015922-5wwy0m2k 34 7 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 34 8 therapy therapy NN cord-015922-5wwy0m2k 34 9 is be VBZ cord-015922-5wwy0m2k 34 10 prescribed prescribe VBN cord-015922-5wwy0m2k 34 11 for for IN cord-015922-5wwy0m2k 34 12 the the DT cord-015922-5wwy0m2k 34 13 treatment treatment NN cord-015922-5wwy0m2k 34 14 and and CC cord-015922-5wwy0m2k 34 15 eradication eradication NN cord-015922-5wwy0m2k 34 16 of of IN cord-015922-5wwy0m2k 34 17 identified identify VBN cord-015922-5wwy0m2k 34 18 microbes microbe NNS cord-015922-5wwy0m2k 34 19 causing cause VBG cord-015922-5wwy0m2k 34 20 clinical clinical JJ cord-015922-5wwy0m2k 34 21 illness illness NN cord-015922-5wwy0m2k 34 22 . . . cord-015922-5wwy0m2k 35 1 2 2 LS cord-015922-5wwy0m2k 35 2 . . . cord-015922-5wwy0m2k 36 1 A a DT cord-015922-5wwy0m2k 36 2 prophylactic prophylactic JJ cord-015922-5wwy0m2k 36 3 mode mode NN cord-015922-5wwy0m2k 36 4 , , , cord-015922-5wwy0m2k 36 5 in in IN cord-015922-5wwy0m2k 36 6 which which WDT cord-015922-5wwy0m2k 36 7 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 36 8 therapy therapy NN cord-015922-5wwy0m2k 36 9 is be VBZ cord-015922-5wwy0m2k 36 10 prescribed prescribe VBN cord-015922-5wwy0m2k 36 11 to to IN cord-015922-5wwy0m2k 36 12 an an DT cord-015922-5wwy0m2k 36 13 entire entire JJ cord-015922-5wwy0m2k 36 14 population population NN cord-015922-5wwy0m2k 36 15 before before IN cord-015922-5wwy0m2k 36 16 an an DT cord-015922-5wwy0m2k 36 17 event event NN cord-015922-5wwy0m2k 36 18 to to TO cord-015922-5wwy0m2k 36 19 prevent prevent VB cord-015922-5wwy0m2k 36 20 clinically clinically RB cord-015922-5wwy0m2k 36 21 important important JJ cord-015922-5wwy0m2k 36 22 infection infection NN cord-015922-5wwy0m2k 36 23 . . . cord-015922-5wwy0m2k 37 1 For for IN cord-015922-5wwy0m2k 37 2 such such PDT cord-015922-5wwy0m2k 37 3 a a DT cord-015922-5wwy0m2k 37 4 strategy strategy NN cord-015922-5wwy0m2k 37 5 to to TO cord-015922-5wwy0m2k 37 6 be be VB cord-015922-5wwy0m2k 37 7 successful successful JJ cord-015922-5wwy0m2k 37 8 , , , cord-015922-5wwy0m2k 37 9 the the DT cord-015922-5wwy0m2k 37 10 infection(s infection(s NNP cord-015922-5wwy0m2k 37 11 ) ) -RRB- cord-015922-5wwy0m2k 37 12 being be VBG cord-015922-5wwy0m2k 37 13 targeted target VBN cord-015922-5wwy0m2k 37 14 must must MD cord-015922-5wwy0m2k 37 15 be be VB cord-015922-5wwy0m2k 37 16 important important JJ cord-015922-5wwy0m2k 37 17 enough enough RB cord-015922-5wwy0m2k 37 18 to to TO cord-015922-5wwy0m2k 37 19 justify justify VB cord-015922-5wwy0m2k 37 20 the the DT cord-015922-5wwy0m2k 37 21 intervention intervention NN cord-015922-5wwy0m2k 37 22 , , , cord-015922-5wwy0m2k 37 23 and and CC cord-015922-5wwy0m2k 37 24 the the DT cord-015922-5wwy0m2k 37 25 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 37 26 therapy therapy NN cord-015922-5wwy0m2k 37 27 prescribed prescribe VBN cord-015922-5wwy0m2k 37 28 must must MD cord-015922-5wwy0m2k 37 29 be be VB cord-015922-5wwy0m2k 37 30 nontoxic nontoxic JJ cord-015922-5wwy0m2k 37 31 and and CC cord-015922-5wwy0m2k 37 32 inexpensive inexpensive JJ cord-015922-5wwy0m2k 37 33 enough enough RB cord-015922-5wwy0m2k 37 34 to to TO cord-015922-5wwy0m2k 37 35 justify justify VB cord-015922-5wwy0m2k 37 36 the the DT cord-015922-5wwy0m2k 37 37 intervention intervention NN cord-015922-5wwy0m2k 37 38 . . . cord-015922-5wwy0m2k 38 1 By by IN cord-015922-5wwy0m2k 38 2 far far RB cord-015922-5wwy0m2k 38 3 the the DT cord-015922-5wwy0m2k 38 4 most most RBS cord-015922-5wwy0m2k 38 5 effective effective JJ cord-015922-5wwy0m2k 38 6 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 38 7 prophylactic prophylactic JJ cord-015922-5wwy0m2k 38 8 strategy strategy NN cord-015922-5wwy0m2k 38 9 is be VBZ cord-015922-5wwy0m2k 38 10 low low JJ cord-015922-5wwy0m2k 38 11 - - HYPH cord-015922-5wwy0m2k 38 12 dose dose NN cord-015922-5wwy0m2k 38 13 trimethoprim trimethoprim NNP cord-015922-5wwy0m2k 38 14 - - HYPH cord-015922-5wwy0m2k 38 15 sulfamethoxazole sulfamethoxazole NNP cord-015922-5wwy0m2k 38 16 , , , cord-015922-5wwy0m2k 38 17 which which WDT cord-015922-5wwy0m2k 38 18 has have VBZ cord-015922-5wwy0m2k 38 19 virtually virtually RB cord-015922-5wwy0m2k 38 20 eliminated eliminate VBN cord-015922-5wwy0m2k 38 21 the the DT cord-015922-5wwy0m2k 38 22 occurrence occurrence NN cord-015922-5wwy0m2k 38 23 of of IN cord-015922-5wwy0m2k 38 24 Pneumocystis Pneumocystis NNP cord-015922-5wwy0m2k 38 25 jiroveci jiroveci NNP cord-015922-5wwy0m2k 38 26 , , , cord-015922-5wwy0m2k 38 27 Listeria Listeria NNP cord-015922-5wwy0m2k 38 28 monocytogenes monocytogenes NN cord-015922-5wwy0m2k 38 29 , , , cord-015922-5wwy0m2k 38 30 Nocardia Nocardia NNP cord-015922-5wwy0m2k 38 31 sp sp NN cord-015922-5wwy0m2k 38 32 , , , cord-015922-5wwy0m2k 38 33 and and CC cord-015922-5wwy0m2k 38 34 Toxoplasma toxoplasma NN cord-015922-5wwy0m2k 38 35 gondii gondii NN cord-015922-5wwy0m2k 38 36 in in IN cord-015922-5wwy0m2k 38 37 patients patient NNS cord-015922-5wwy0m2k 38 38 who who WP cord-015922-5wwy0m2k 38 39 adhere adhere VBP cord-015922-5wwy0m2k 38 40 to to IN cord-015922-5wwy0m2k 38 41 the the DT cord-015922-5wwy0m2k 38 42 regimen regimen NN cord-015922-5wwy0m2k 38 43 . . . cord-015922-5wwy0m2k 39 1 Other other JJ cord-015922-5wwy0m2k 39 2 prophylactic prophylactic JJ cord-015922-5wwy0m2k 39 3 strategies strategy NNS cord-015922-5wwy0m2k 39 4 commonly commonly RB cord-015922-5wwy0m2k 39 5 utilized utilize VBN cord-015922-5wwy0m2k 39 6 in in IN cord-015922-5wwy0m2k 39 7 HSCT HSCT NNP cord-015922-5wwy0m2k 39 8 patients patient NNS cord-015922-5wwy0m2k 39 9 include include VBP cord-015922-5wwy0m2k 39 10 acyclovir acyclovir NNP cord-015922-5wwy0m2k 39 11 to to TO cord-015922-5wwy0m2k 39 12 prevent prevent VB cord-015922-5wwy0m2k 39 13 herpes herpes NN cord-015922-5wwy0m2k 39 14 simplex simplex NN cord-015922-5wwy0m2k 39 15 virus virus NN cord-015922-5wwy0m2k 39 16 ( ( -LRB- cord-015922-5wwy0m2k 39 17 HSV HSV NNP cord-015922-5wwy0m2k 39 18 ) ) -RRB- cord-015922-5wwy0m2k 39 19 and and CC cord-015922-5wwy0m2k 39 20 VZV VZV NNP cord-015922-5wwy0m2k 39 21 reactivation reactivation NN cord-015922-5wwy0m2k 39 22 , , , cord-015922-5wwy0m2k 39 23 fluoroquinolones fluoroquinolone NNS cord-015922-5wwy0m2k 39 24 [ [ -LRB- cord-015922-5wwy0m2k 39 25 5 5 CD cord-015922-5wwy0m2k 39 26 ] ] -RRB- cord-015922-5wwy0m2k 39 27 to to TO cord-015922-5wwy0m2k 39 28 prevent prevent VB cord-015922-5wwy0m2k 39 29 gram gram NN cord-015922-5wwy0m2k 39 30 - - HYPH cord-015922-5wwy0m2k 39 31 negative negative JJ cord-015922-5wwy0m2k 39 32 sepsis sepsis NN cord-015922-5wwy0m2k 39 33 and and CC cord-015922-5wwy0m2k 39 34 fluconazole fluconazole NN cord-015922-5wwy0m2k 39 35 to to TO cord-015922-5wwy0m2k 39 36 prevent prevent VB cord-015922-5wwy0m2k 39 37 yeast yeast NN cord-015922-5wwy0m2k 39 38 infection infection NN cord-015922-5wwy0m2k 39 39 . . . cord-015922-5wwy0m2k 40 1 3 3 LS cord-015922-5wwy0m2k 40 2 . . . cord-015922-5wwy0m2k 41 1 An an DT cord-015922-5wwy0m2k 41 2 empiric empiric JJ cord-015922-5wwy0m2k 41 3 mode mode NN cord-015922-5wwy0m2k 41 4 , , , cord-015922-5wwy0m2k 41 5 in in IN cord-015922-5wwy0m2k 41 6 which which WDT cord-015922-5wwy0m2k 41 7 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 41 8 therapy therapy NN cord-015922-5wwy0m2k 41 9 is be VBZ cord-015922-5wwy0m2k 41 10 administered administer VBN cord-015922-5wwy0m2k 41 11 in in IN cord-015922-5wwy0m2k 41 12 response response NN cord-015922-5wwy0m2k 41 13 to to IN cord-015922-5wwy0m2k 41 14 a a DT cord-015922-5wwy0m2k 41 15 symptom symptom NN cord-015922-5wwy0m2k 41 16 complex complex NN cord-015922-5wwy0m2k 41 17 . . . cord-015922-5wwy0m2k 42 1 In in IN cord-015922-5wwy0m2k 42 2 this this DT cord-015922-5wwy0m2k 42 3 context context NN cord-015922-5wwy0m2k 42 4 , , , cord-015922-5wwy0m2k 42 5 empiric empiric JJ cord-015922-5wwy0m2k 42 6 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 42 7 therapy therapy NN cord-015922-5wwy0m2k 42 8 is be VBZ cord-015922-5wwy0m2k 42 9 initiated initiate VBN cord-015922-5wwy0m2k 42 10 during during IN cord-015922-5wwy0m2k 42 11 the the DT cord-015922-5wwy0m2k 42 12 period period NN cord-015922-5wwy0m2k 42 13 of of IN cord-015922-5wwy0m2k 42 14 profound profound JJ cord-015922-5wwy0m2k 42 15 granulocytopenia granulocytopenia NNP cord-015922-5wwy0m2k 42 16 in in IN cord-015922-5wwy0m2k 42 17 response response NN cord-015922-5wwy0m2k 42 18 to to IN cord-015922-5wwy0m2k 42 19 fever fever NN cord-015922-5wwy0m2k 42 20 + + . cord-015922-5wwy0m2k 43 1 /− /− . cord-015922-5wwy0m2k 43 2 rigors rigor NNS cord-015922-5wwy0m2k 43 3 or or CC cord-015922-5wwy0m2k 43 4 subtle subtle JJ cord-015922-5wwy0m2k 43 5 signs sign NNS cord-015922-5wwy0m2k 43 6 of of IN cord-015922-5wwy0m2k 43 7 sepsis sepsis NN cord-015922-5wwy0m2k 44 1 ( ( -LRB- cord-015922-5wwy0m2k 44 2 unexplained unexplained JJ cord-015922-5wwy0m2k 44 3 hypotension hypotension NN cord-015922-5wwy0m2k 44 4 , , , cord-015922-5wwy0m2k 44 5 tachypnea tachypnea NNP cord-015922-5wwy0m2k 44 6 , , , cord-015922-5wwy0m2k 44 7 an an DT cord-015922-5wwy0m2k 44 8 ongoing ongoing JJ cord-015922-5wwy0m2k 44 9 volume volume NN cord-015922-5wwy0m2k 44 10 requirement requirement NN cord-015922-5wwy0m2k 44 11 , , , cord-015922-5wwy0m2k 44 12 or or CC cord-015922-5wwy0m2k 44 13 acidosis acidosis NN cord-015922-5wwy0m2k 44 14 ) ) -RRB- cord-015922-5wwy0m2k 44 15 . . . cord-015922-5wwy0m2k 45 1 In in IN cord-015922-5wwy0m2k 45 2 the the DT cord-015922-5wwy0m2k 45 3 patient patient NN cord-015922-5wwy0m2k 45 4 deemed deem VBN cord-015922-5wwy0m2k 45 5 not not RB cord-015922-5wwy0m2k 45 6 to to TO cord-015922-5wwy0m2k 45 7 be be VB cord-015922-5wwy0m2k 45 8 a a DT cord-015922-5wwy0m2k 45 9 therapeutic therapeutic JJ cord-015922-5wwy0m2k 45 10 emergency emergency NN cord-015922-5wwy0m2k 45 11 , , , cord-015922-5wwy0m2k 45 12 initial initial JJ cord-015922-5wwy0m2k 45 13 therapy therapy NN cord-015922-5wwy0m2k 45 14 is be VBZ cord-015922-5wwy0m2k 45 15 usually usually RB cord-015922-5wwy0m2k 45 16 aimed aim VBN cord-015922-5wwy0m2k 45 17 at at IN cord-015922-5wwy0m2k 45 18 aerobic aerobic JJ cord-015922-5wwy0m2k 45 19 gramnegative gramnegative NNP cord-015922-5wwy0m2k 45 20 bacilli bacilli NN cord-015922-5wwy0m2k 45 21 ( ( -LRB- cord-015922-5wwy0m2k 45 22 e.g. e.g. RB cord-015922-5wwy0m2k 45 23 , , , cord-015922-5wwy0m2k 45 24 the the DT cord-015922-5wwy0m2k 45 25 Enterobacteriaceae Enterobacteriaceae NNP cord-015922-5wwy0m2k 45 26 and and CC cord-015922-5wwy0m2k 45 27 Pseudomonas Pseudomonas NNP cord-015922-5wwy0m2k 45 28 aeruginosa aeruginosa NN cord-015922-5wwy0m2k 45 29 ) ) -RRB- cord-015922-5wwy0m2k 45 30 . . . cord-015922-5wwy0m2k 46 1 A a DT cord-015922-5wwy0m2k 46 2 variety variety NN cord-015922-5wwy0m2k 46 3 of of IN cord-015922-5wwy0m2k 46 4 drugs drug NNS cord-015922-5wwy0m2k 46 5 have have VBP cord-015922-5wwy0m2k 46 6 been be VBN cord-015922-5wwy0m2k 46 7 utilized utilize VBN cord-015922-5wwy0m2k 46 8 for for IN cord-015922-5wwy0m2k 46 9 this this DT cord-015922-5wwy0m2k 46 10 purpose purpose NN cord-015922-5wwy0m2k 46 11 , , , cord-015922-5wwy0m2k 46 12 depending depend VBG cord-015922-5wwy0m2k 46 13 in in IN cord-015922-5wwy0m2k 46 14 part part NN cord-015922-5wwy0m2k 46 15 on on IN cord-015922-5wwy0m2k 46 16 the the DT cord-015922-5wwy0m2k 46 17 nature nature NN cord-015922-5wwy0m2k 46 18 of of IN cord-015922-5wwy0m2k 46 19 particular particular JJ cord-015922-5wwy0m2k 46 20 problem problem NN cord-015922-5wwy0m2k 46 21 organisms organism NNS cord-015922-5wwy0m2k 46 22 found find VBD cord-015922-5wwy0m2k 46 23 at at IN cord-015922-5wwy0m2k 46 24 a a DT cord-015922-5wwy0m2k 46 25 given give VBN cord-015922-5wwy0m2k 46 26 medical medical JJ cord-015922-5wwy0m2k 46 27 center center NN cord-015922-5wwy0m2k 46 28 . . . cord-015922-5wwy0m2k 47 1 Advanced advanced JJ cord-015922-5wwy0m2k 47 2 spectrum spectrum NN cord-015922-5wwy0m2k 47 3 beta beta NN cord-015922-5wwy0m2k 47 4 - - HYPH cord-015922-5wwy0m2k 47 5 lactams lactam NNS cord-015922-5wwy0m2k 47 6 ( ( -LRB- cord-015922-5wwy0m2k 47 7 e.g. e.g. RB cord-015922-5wwy0m2k 47 8 , , , cord-015922-5wwy0m2k 47 9 ceftazidime ceftazidime NN cord-015922-5wwy0m2k 47 10 , , , cord-015922-5wwy0m2k 47 11 piperacillin piperacillin NNP cord-015922-5wwy0m2k 47 12 or or CC cord-015922-5wwy0m2k 47 13 imipenem imipenem NNP cord-015922-5wwy0m2k 47 14 ) ) -RRB- cord-015922-5wwy0m2k 47 15 , , , cord-015922-5wwy0m2k 48 1 either either CC cord-015922-5wwy0m2k 48 2 alone alone RB cord-015922-5wwy0m2k 48 3 or or CC cord-015922-5wwy0m2k 48 4 together together RB cord-015922-5wwy0m2k 48 5 with with IN cord-015922-5wwy0m2k 48 6 an an DT cord-015922-5wwy0m2k 48 7 aminoglycoside aminoglycoside NN cord-015922-5wwy0m2k 48 8 or or CC cord-015922-5wwy0m2k 48 9 a a DT cord-015922-5wwy0m2k 48 10 fluoroquinolone fluoroquinolone NN cord-015922-5wwy0m2k 48 11 , , , cord-015922-5wwy0m2k 48 12 are be VBP cord-015922-5wwy0m2k 48 13 the the DT cord-015922-5wwy0m2k 48 14 mainstays mainstay NNS cord-015922-5wwy0m2k 48 15 of of IN cord-015922-5wwy0m2k 48 16 this this DT cord-015922-5wwy0m2k 48 17 approach approach NN cord-015922-5wwy0m2k 48 18 . . . cord-015922-5wwy0m2k 49 1 Thus thus RB cord-015922-5wwy0m2k 49 2 , , , cord-015922-5wwy0m2k 49 3 empiric empiric JJ cord-015922-5wwy0m2k 49 4 therapy therapy NN cord-015922-5wwy0m2k 49 5 is be VBZ cord-015922-5wwy0m2k 49 6 based base VBN cord-015922-5wwy0m2k 49 7 on on IN cord-015922-5wwy0m2k 49 8 an an DT cord-015922-5wwy0m2k 49 9 algorithm algorithm NN cord-015922-5wwy0m2k 49 10 rather rather RB cord-015922-5wwy0m2k 49 11 than than IN cord-015922-5wwy0m2k 49 12 on on IN cord-015922-5wwy0m2k 49 13 microbiologic microbiologic NNP cord-015922-5wwy0m2k 49 14 or or CC cord-015922-5wwy0m2k 49 15 other other JJ cord-015922-5wwy0m2k 49 16 studies study NNS cord-015922-5wwy0m2k 49 17 . . . cord-015922-5wwy0m2k 50 1 4 4 LS cord-015922-5wwy0m2k 50 2 . . . cord-015922-5wwy0m2k 51 1 A a DT cord-015922-5wwy0m2k 51 2 preemptive preemptive JJ cord-015922-5wwy0m2k 51 3 mode mode NN cord-015922-5wwy0m2k 51 4 , , , cord-015922-5wwy0m2k 51 5 in in IN cord-015922-5wwy0m2k 51 6 which which WDT cord-015922-5wwy0m2k 51 7 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 51 8 therapy therapy NN cord-015922-5wwy0m2k 51 9 is be VBZ cord-015922-5wwy0m2k 51 10 prescribed prescribe VBN cord-015922-5wwy0m2k 51 11 to to IN cord-015922-5wwy0m2k 51 12 a a DT cord-015922-5wwy0m2k 51 13 proportion proportion NN cord-015922-5wwy0m2k 51 14 of of IN cord-015922-5wwy0m2k 51 15 patients patient NNS cord-015922-5wwy0m2k 51 16 deemed deem VBN cord-015922-5wwy0m2k 51 17 to to TO cord-015922-5wwy0m2k 51 18 be be VB cord-015922-5wwy0m2k 51 19 at at IN cord-015922-5wwy0m2k 51 20 particularly particularly RB cord-015922-5wwy0m2k 51 21 high high JJ cord-015922-5wwy0m2k 51 22 risk risk NN cord-015922-5wwy0m2k 51 23 because because IN cord-015922-5wwy0m2k 51 24 of of IN cord-015922-5wwy0m2k 51 25 clinical clinical JJ cord-015922-5wwy0m2k 51 26 / / SYM cord-015922-5wwy0m2k 51 27 epidemiologic epidemiologic JJ cord-015922-5wwy0m2k 51 28 information information NN cord-015922-5wwy0m2k 51 29 or or CC cord-015922-5wwy0m2k 51 30 the the DT cord-015922-5wwy0m2k 51 31 isolation isolation NN cord-015922-5wwy0m2k 51 32 of of IN cord-015922-5wwy0m2k 51 33 microbial microbial JJ cord-015922-5wwy0m2k 51 34 pathogens pathogen NNS cord-015922-5wwy0m2k 51 35 . . . cord-015922-5wwy0m2k 52 1 Examples example NNS cord-015922-5wwy0m2k 52 2 of of IN cord-015922-5wwy0m2k 52 3 preemptive preemptive JJ cord-015922-5wwy0m2k 52 4 therapy therapy NN cord-015922-5wwy0m2k 52 5 in in IN cord-015922-5wwy0m2k 52 6 HSCT HSCT NNP cord-015922-5wwy0m2k 52 7 are be VBP cord-015922-5wwy0m2k 52 8 the the DT cord-015922-5wwy0m2k 52 9 molecular molecular JJ cord-015922-5wwy0m2k 52 10 surveillance surveillance NN cord-015922-5wwy0m2k 52 11 of of IN cord-015922-5wwy0m2k 52 12 CMV CMV NNP cord-015922-5wwy0m2k 52 13 linked link VBN cord-015922-5wwy0m2k 52 14 to to IN cord-015922-5wwy0m2k 52 15 deployment deployment NN cord-015922-5wwy0m2k 52 16 of of IN cord-015922-5wwy0m2k 52 17 ganciclovir ganciclovir NNP cord-015922-5wwy0m2k 52 18 or or CC cord-015922-5wwy0m2k 52 19 , , , cord-015922-5wwy0m2k 52 20 more more RBR cord-015922-5wwy0m2k 52 21 recently recently RB cord-015922-5wwy0m2k 52 22 , , , cord-015922-5wwy0m2k 52 23 the the DT cord-015922-5wwy0m2k 52 24 use use NN cord-015922-5wwy0m2k 52 25 of of IN cord-015922-5wwy0m2k 52 26 galactomannan galactomannan NNP cord-015922-5wwy0m2k 52 27 monitoring monitoring NN cord-015922-5wwy0m2k 52 28 for for IN cord-015922-5wwy0m2k 52 29 initiation initiation NN cord-015922-5wwy0m2k 52 30 of of IN cord-015922-5wwy0m2k 52 31 anti anti JJ cord-015922-5wwy0m2k 52 32 - - JJ cord-015922-5wwy0m2k 52 33 Aspergillus aspergillus JJ cord-015922-5wwy0m2k 52 34 antifungal antifungal NN cord-015922-5wwy0m2k 52 35 treatment treatment NN cord-015922-5wwy0m2k 52 36 [ [ -LRB- cord-015922-5wwy0m2k 52 37 12 12 CD cord-015922-5wwy0m2k 52 38 ] ] -RRB- cord-015922-5wwy0m2k 52 39 . . . cord-015922-5wwy0m2k 53 1 Given give VBN cord-015922-5wwy0m2k 53 2 the the DT cord-015922-5wwy0m2k 53 3 nature nature NN cord-015922-5wwy0m2k 53 4 , , , cord-015922-5wwy0m2k 53 5 duration duration NN cord-015922-5wwy0m2k 53 6 and and CC cord-015922-5wwy0m2k 53 7 severity severity NN cord-015922-5wwy0m2k 53 8 of of IN cord-015922-5wwy0m2k 53 9 host host NN cord-015922-5wwy0m2k 53 10 defense defense NN cord-015922-5wwy0m2k 53 11 defects defect NNS cord-015922-5wwy0m2k 53 12 present present JJ cord-015922-5wwy0m2k 53 13 in in IN cord-015922-5wwy0m2k 53 14 HSCT HSCT NNP cord-015922-5wwy0m2k 53 15 patients patient NNS cord-015922-5wwy0m2k 53 16 , , , cord-015922-5wwy0m2k 53 17 it -PRON- PRP cord-015922-5wwy0m2k 53 18 is be VBZ cord-015922-5wwy0m2k 53 19 not not RB cord-015922-5wwy0m2k 53 20 surprising surprising JJ cord-015922-5wwy0m2k 53 21 that that IN cord-015922-5wwy0m2k 53 22 bacterial bacterial JJ cord-015922-5wwy0m2k 53 23 infection infection NN cord-015922-5wwy0m2k 53 24 is be VBZ cord-015922-5wwy0m2k 53 25 a a DT cord-015922-5wwy0m2k 53 26 regular regular JJ cord-015922-5wwy0m2k 53 27 feature feature NN cord-015922-5wwy0m2k 53 28 of of IN cord-015922-5wwy0m2k 53 29 the the DT cord-015922-5wwy0m2k 53 30 post post JJ cord-015922-5wwy0m2k 53 31 - - JJ cord-015922-5wwy0m2k 53 32 transplant transplant JJ cord-015922-5wwy0m2k 53 33 course course NN cord-015922-5wwy0m2k 53 34 . . . cord-015922-5wwy0m2k 54 1 The the DT cord-015922-5wwy0m2k 54 2 most most RBS cord-015922-5wwy0m2k 54 3 common common JJ cord-015922-5wwy0m2k 54 4 involved involved JJ cord-015922-5wwy0m2k 54 5 sites site NNS cord-015922-5wwy0m2k 54 6 include include VBP cord-015922-5wwy0m2k 54 7 blood blood NN cord-015922-5wwy0m2k 54 8 stream stream NN cord-015922-5wwy0m2k 54 9 ( ( -LRB- cord-015922-5wwy0m2k 54 10 often often RB cord-015922-5wwy0m2k 54 11 catheter catheter NN cord-015922-5wwy0m2k 54 12 - - HYPH cord-015922-5wwy0m2k 54 13 related relate VBN cord-015922-5wwy0m2k 54 14 ) ) -RRB- cord-015922-5wwy0m2k 54 15 , , , cord-015922-5wwy0m2k 54 16 lung lung NN cord-015922-5wwy0m2k 54 17 , , , cord-015922-5wwy0m2k 54 18 gastrointestinal gastrointestinal JJ cord-015922-5wwy0m2k 54 19 tract tract NN cord-015922-5wwy0m2k 54 20 and and CC cord-015922-5wwy0m2k 54 21 skin skin NN cord-015922-5wwy0m2k 54 22 / / SYM cord-015922-5wwy0m2k 54 23 soft soft JJ cord-015922-5wwy0m2k 54 24 tissue tissue NN cord-015922-5wwy0m2k 54 25 . . . cord-015922-5wwy0m2k 55 1 The the DT cord-015922-5wwy0m2k 55 2 greatest great JJS cord-015922-5wwy0m2k 55 3 rate rate NN cord-015922-5wwy0m2k 55 4 of of IN cord-015922-5wwy0m2k 55 5 bacterial bacterial JJ cord-015922-5wwy0m2k 55 6 infections infection NNS cord-015922-5wwy0m2k 55 7 occur occur VBP cord-015922-5wwy0m2k 55 8 during during IN cord-015922-5wwy0m2k 55 9 the the DT cord-015922-5wwy0m2k 55 10 period period NN cord-015922-5wwy0m2k 55 11 prior prior RB cord-015922-5wwy0m2k 55 12 to to IN cord-015922-5wwy0m2k 55 13 engraftment engraftment NN cord-015922-5wwy0m2k 55 14 ; ; : cord-015922-5wwy0m2k 55 15 this this DT cord-015922-5wwy0m2k 55 16 rate rate NN cord-015922-5wwy0m2k 55 17 is be VBZ cord-015922-5wwy0m2k 55 18 a a DT cord-015922-5wwy0m2k 55 19 product product NN cord-015922-5wwy0m2k 55 20 of of IN cord-015922-5wwy0m2k 55 21 granulocytopenia granulocytopenia NNP cord-015922-5wwy0m2k 55 22 , , , cord-015922-5wwy0m2k 55 23 mucositis mucositis NNP cord-015922-5wwy0m2k 55 24 that that WDT cord-015922-5wwy0m2k 55 25 permits permit VBZ cord-015922-5wwy0m2k 55 26 the the DT cord-015922-5wwy0m2k 55 27 translocation translocation NN cord-015922-5wwy0m2k 55 28 of of IN cord-015922-5wwy0m2k 55 29 bacteria bacteria NNS cord-015922-5wwy0m2k 55 30 and and CC cord-015922-5wwy0m2k 55 31 yeast yeast NN cord-015922-5wwy0m2k 55 32 from from IN cord-015922-5wwy0m2k 55 33 the the DT cord-015922-5wwy0m2k 55 34 oral oral JJ cord-015922-5wwy0m2k 55 35 cavity cavity NN cord-015922-5wwy0m2k 55 36 and and CC cord-015922-5wwy0m2k 55 37 gut gut NN cord-015922-5wwy0m2k 55 38 into into IN cord-015922-5wwy0m2k 55 39 circulation circulation NN cord-015922-5wwy0m2k 55 40 , , , cord-015922-5wwy0m2k 55 41 and and CC cord-015922-5wwy0m2k 55 42 the the DT cord-015922-5wwy0m2k 55 43 presence presence NN cord-015922-5wwy0m2k 55 44 of of IN cord-015922-5wwy0m2k 55 45 vascular vascular JJ cord-015922-5wwy0m2k 55 46 access access NN cord-015922-5wwy0m2k 55 47 devices device NNS cord-015922-5wwy0m2k 55 48 that that WDT cord-015922-5wwy0m2k 55 49 traverse traverse VBP cord-015922-5wwy0m2k 55 50 the the DT cord-015922-5wwy0m2k 55 51 skin skin NN cord-015922-5wwy0m2k 55 52 and and CC cord-015922-5wwy0m2k 55 53 serve serve VB cord-015922-5wwy0m2k 55 54 as as IN cord-015922-5wwy0m2k 55 55 direct direct JJ cord-015922-5wwy0m2k 55 56 conduits conduit NNS cord-015922-5wwy0m2k 55 57 into into IN cord-015922-5wwy0m2k 55 58 the the DT cord-015922-5wwy0m2k 55 59 systemic systemic JJ cord-015922-5wwy0m2k 55 60 circulation circulation NN cord-015922-5wwy0m2k 55 61 . . . cord-015922-5wwy0m2k 56 1 Thus thus RB cord-015922-5wwy0m2k 56 2 , , , cord-015922-5wwy0m2k 56 3 the the DT cord-015922-5wwy0m2k 56 4 primary primary JJ cord-015922-5wwy0m2k 56 5 mucocutaneous mucocutaneous JJ cord-015922-5wwy0m2k 56 6 barriers barrier NNS cord-015922-5wwy0m2k 56 7 to to IN cord-015922-5wwy0m2k 56 8 infection infection NN cord-015922-5wwy0m2k 56 9 are be VBP cord-015922-5wwy0m2k 56 10 compromised compromise VBN cord-015922-5wwy0m2k 56 11 , , , cord-015922-5wwy0m2k 56 12 and and CC cord-015922-5wwy0m2k 56 13 the the DT cord-015922-5wwy0m2k 56 14 absence absence NN cord-015922-5wwy0m2k 56 15 of of IN cord-015922-5wwy0m2k 56 16 granulocytes granulocyte NNS cord-015922-5wwy0m2k 56 17 only only RB cord-015922-5wwy0m2k 56 18 amplifies amplify VBZ cord-015922-5wwy0m2k 56 19 the the DT cord-015922-5wwy0m2k 56 20 susceptibility susceptibility NN cord-015922-5wwy0m2k 56 21 of of IN cord-015922-5wwy0m2k 56 22 the the DT cord-015922-5wwy0m2k 56 23 patient patient NN cord-015922-5wwy0m2k 56 24 [ [ -LRB- cord-015922-5wwy0m2k 56 25 1 1 CD cord-015922-5wwy0m2k 56 26 , , , cord-015922-5wwy0m2k 56 27 4 4 CD cord-015922-5wwy0m2k 56 28 , , , cord-015922-5wwy0m2k 56 29 7 7 CD cord-015922-5wwy0m2k 56 30 ] ] -RRB- cord-015922-5wwy0m2k 56 31 . . . cord-015922-5wwy0m2k 57 1 In in IN cord-015922-5wwy0m2k 57 2 an an DT cord-015922-5wwy0m2k 57 3 attempt attempt NN cord-015922-5wwy0m2k 57 4 to to TO cord-015922-5wwy0m2k 57 5 decrease decrease VB cord-015922-5wwy0m2k 57 6 bacterial bacterial JJ cord-015922-5wwy0m2k 57 7 infections infection NNS cord-015922-5wwy0m2k 57 8 during during IN cord-015922-5wwy0m2k 57 9 the the DT cord-015922-5wwy0m2k 57 10 neutropenic neutropenic JJ cord-015922-5wwy0m2k 57 11 period period NN cord-015922-5wwy0m2k 57 12 , , , cord-015922-5wwy0m2k 57 13 especially especially RB cord-015922-5wwy0m2k 57 14 those those DT cord-015922-5wwy0m2k 57 15 due due JJ cord-015922-5wwy0m2k 57 16 to to IN cord-015922-5wwy0m2k 57 17 gram gram NN cord-015922-5wwy0m2k 57 18 - - HYPH cord-015922-5wwy0m2k 57 19 negative negative JJ cord-015922-5wwy0m2k 57 20 bacilli bacilli NN cord-015922-5wwy0m2k 57 21 , , , cord-015922-5wwy0m2k 57 22 strategies strategy NNS cord-015922-5wwy0m2k 57 23 of of IN cord-015922-5wwy0m2k 57 24 prophylactic prophylactic JJ cord-015922-5wwy0m2k 57 25 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 57 26 use use NN cord-015922-5wwy0m2k 57 27 have have VBP cord-015922-5wwy0m2k 57 28 been be VBN cord-015922-5wwy0m2k 57 29 studied study VBN cord-015922-5wwy0m2k 57 30 , , , cord-015922-5wwy0m2k 57 31 including include VBG cord-015922-5wwy0m2k 57 32 the the DT cord-015922-5wwy0m2k 57 33 use use NN cord-015922-5wwy0m2k 57 34 of of IN cord-015922-5wwy0m2k 57 35 trimethoprimsulfamethoxazole trimethoprimsulfamethoxazole NN cord-015922-5wwy0m2k 57 36 and and CC cord-015922-5wwy0m2k 57 37 fluoroquinolones fluoroquinolone NNS cord-015922-5wwy0m2k 57 38 . . . cord-015922-5wwy0m2k 58 1 Some some DT cord-015922-5wwy0m2k 58 2 studies study NNS cord-015922-5wwy0m2k 58 3 , , , cord-015922-5wwy0m2k 58 4 most most RBS cord-015922-5wwy0m2k 58 5 recently recently RB cord-015922-5wwy0m2k 58 6 with with IN cord-015922-5wwy0m2k 58 7 levofloxacin levofloxacin NNS cord-015922-5wwy0m2k 58 8 , , , cord-015922-5wwy0m2k 58 9 have have VBP cord-015922-5wwy0m2k 58 10 demonstrated demonstrate VBN cord-015922-5wwy0m2k 58 11 benefit benefit NN cord-015922-5wwy0m2k 58 12 in in IN cord-015922-5wwy0m2k 58 13 decreasing decrease VBG cord-015922-5wwy0m2k 58 14 the the DT cord-015922-5wwy0m2k 58 15 occurrence occurrence NN cord-015922-5wwy0m2k 58 16 of of IN cord-015922-5wwy0m2k 58 17 fever fever NN cord-015922-5wwy0m2k 58 18 and and CC cord-015922-5wwy0m2k 58 19 microbiologically microbiologically RB cord-015922-5wwy0m2k 58 20 - - HYPH cord-015922-5wwy0m2k 58 21 confirmed confirm VBN cord-015922-5wwy0m2k 58 22 bacterial bacterial JJ cord-015922-5wwy0m2k 58 23 infections infection NNS cord-015922-5wwy0m2k 58 24 [ [ -LRB- cord-015922-5wwy0m2k 58 25 13 13 CD cord-015922-5wwy0m2k 58 26 ] ] -RRB- cord-015922-5wwy0m2k 58 27 [ [ -LRB- cord-015922-5wwy0m2k 58 28 14 14 CD cord-015922-5wwy0m2k 58 29 ] ] -RRB- cord-015922-5wwy0m2k 58 30 [ [ -LRB- cord-015922-5wwy0m2k 58 31 15 15 CD cord-015922-5wwy0m2k 58 32 ] ] -RRB- cord-015922-5wwy0m2k 58 33 . . . cord-015922-5wwy0m2k 59 1 However however RB cord-015922-5wwy0m2k 59 2 , , , cord-015922-5wwy0m2k 59 3 significant significant JJ cord-015922-5wwy0m2k 59 4 concerns concern NNS cord-015922-5wwy0m2k 59 5 regarding regard VBG cord-015922-5wwy0m2k 59 6 this this DT cord-015922-5wwy0m2k 59 7 approach approach NN cord-015922-5wwy0m2k 59 8 have have VBP cord-015922-5wwy0m2k 59 9 been be VBN cord-015922-5wwy0m2k 59 10 raised raise VBN cord-015922-5wwy0m2k 59 11 given give VBN cord-015922-5wwy0m2k 59 12 that that IN cord-015922-5wwy0m2k 59 13 no no DT cord-015922-5wwy0m2k 59 14 mortality mortality NN cord-015922-5wwy0m2k 59 15 benefit benefit NN cord-015922-5wwy0m2k 59 16 has have VBZ cord-015922-5wwy0m2k 59 17 been be VBN cord-015922-5wwy0m2k 59 18 demonstrated demonstrate VBN cord-015922-5wwy0m2k 59 19 , , , cord-015922-5wwy0m2k 59 20 the the DT cord-015922-5wwy0m2k 59 21 emergence emergence NN cord-015922-5wwy0m2k 59 22 of of IN cord-015922-5wwy0m2k 59 23 resistant resistant JJ cord-015922-5wwy0m2k 59 24 organisms organism NNS cord-015922-5wwy0m2k 59 25 , , , cord-015922-5wwy0m2k 59 26 and and CC cord-015922-5wwy0m2k 59 27 the the DT cord-015922-5wwy0m2k 59 28 impairment impairment NN cord-015922-5wwy0m2k 59 29 this this DT cord-015922-5wwy0m2k 59 30 widespread widespread JJ cord-015922-5wwy0m2k 59 31 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 59 32 approach approach NN cord-015922-5wwy0m2k 59 33 has have VBZ cord-015922-5wwy0m2k 59 34 on on IN cord-015922-5wwy0m2k 59 35 the the DT cord-015922-5wwy0m2k 59 36 use use NN cord-015922-5wwy0m2k 59 37 of of IN cord-015922-5wwy0m2k 59 38 quinolones quinolone NNS cord-015922-5wwy0m2k 59 39 in in IN cord-015922-5wwy0m2k 59 40 future future JJ cord-015922-5wwy0m2k 59 41 oral oral JJ cord-015922-5wwy0m2k 59 42 outpatient outpatient NN cord-015922-5wwy0m2k 59 43 management management NN cord-015922-5wwy0m2k 59 44 . . . cord-015922-5wwy0m2k 60 1 Thus thus RB cord-015922-5wwy0m2k 60 2 , , , cord-015922-5wwy0m2k 60 3 in in IN cord-015922-5wwy0m2k 60 4 many many JJ cord-015922-5wwy0m2k 60 5 transplant transplant NN cord-015922-5wwy0m2k 60 6 centers center NNS cord-015922-5wwy0m2k 60 7 , , , cord-015922-5wwy0m2k 60 8 an an DT cord-015922-5wwy0m2k 60 9 empiric empiric JJ cord-015922-5wwy0m2k 60 10 antibacterial antibacterial JJ cord-015922-5wwy0m2k 60 11 regimen regimen NN cord-015922-5wwy0m2k 60 12 targeting target VBG cord-015922-5wwy0m2k 60 13 Pseudomonas Pseudomonas NNP cord-015922-5wwy0m2k 60 14 and and CC cord-015922-5wwy0m2k 60 15 other other JJ cord-015922-5wwy0m2k 60 16 Enterobacteriaceae Enterobacteriaceae NNP cord-015922-5wwy0m2k 60 17 in in IN cord-015922-5wwy0m2k 60 18 response response NN cord-015922-5wwy0m2k 60 19 to to IN cord-015922-5wwy0m2k 60 20 fever fever NN cord-015922-5wwy0m2k 60 21 or or CC cord-015922-5wwy0m2k 60 22 other other JJ cord-015922-5wwy0m2k 60 23 infectious infectious JJ cord-015922-5wwy0m2k 60 24 syndromes syndrome NNS cord-015922-5wwy0m2k 60 25 remains remain VBZ cord-015922-5wwy0m2k 60 26 a a DT cord-015922-5wwy0m2k 60 27 preferred preferred JJ cord-015922-5wwy0m2k 60 28 approach approach NN cord-015922-5wwy0m2k 60 29 . . . cord-015922-5wwy0m2k 61 1 Whereas whereas IN cord-015922-5wwy0m2k 61 2 gram gram NN cord-015922-5wwy0m2k 61 3 - - HYPH cord-015922-5wwy0m2k 61 4 negative negative JJ cord-015922-5wwy0m2k 61 5 bacteremia bacteremia NN cord-015922-5wwy0m2k 61 6 was be VBD cord-015922-5wwy0m2k 61 7 the the DT cord-015922-5wwy0m2k 61 8 major major JJ cord-015922-5wwy0m2k 61 9 cause cause NN cord-015922-5wwy0m2k 61 10 of of IN cord-015922-5wwy0m2k 61 11 blood blood NN cord-015922-5wwy0m2k 61 12 stream stream NN cord-015922-5wwy0m2k 61 13 infection infection NN cord-015922-5wwy0m2k 61 14 15 15 CD cord-015922-5wwy0m2k 61 15 to to TO cord-015922-5wwy0m2k 61 16 30 30 CD cord-015922-5wwy0m2k 61 17 years year NNS cord-015922-5wwy0m2k 61 18 ago ago RB cord-015922-5wwy0m2k 61 19 , , , cord-015922-5wwy0m2k 61 20 today today NN cord-015922-5wwy0m2k 61 21 gram gram NN cord-015922-5wwy0m2k 61 22 - - HYPH cord-015922-5wwy0m2k 61 23 positive positive JJ cord-015922-5wwy0m2k 61 24 organisms organism NNS cord-015922-5wwy0m2k 61 25 are be VBP cord-015922-5wwy0m2k 61 26 the the DT cord-015922-5wwy0m2k 61 27 most most RBS cord-015922-5wwy0m2k 61 28 frequent frequent JJ cord-015922-5wwy0m2k 61 29 cause cause NN cord-015922-5wwy0m2k 61 30 of of IN cord-015922-5wwy0m2k 61 31 positive positive JJ cord-015922-5wwy0m2k 61 32 blood blood NN cord-015922-5wwy0m2k 61 33 cultures culture NNS cord-015922-5wwy0m2k 61 34 . . . cord-015922-5wwy0m2k 62 1 The the DT cord-015922-5wwy0m2k 62 2 possible possible JJ cord-015922-5wwy0m2k 62 3 reasons reason NNS cord-015922-5wwy0m2k 62 4 for for IN cord-015922-5wwy0m2k 62 5 this this DT cord-015922-5wwy0m2k 62 6 shift shift NN cord-015922-5wwy0m2k 62 7 are be VBP cord-015922-5wwy0m2k 62 8 many many JJ cord-015922-5wwy0m2k 62 9 : : : cord-015922-5wwy0m2k 62 10 the the DT cord-015922-5wwy0m2k 62 11 widespread widespread JJ cord-015922-5wwy0m2k 62 12 use use NN cord-015922-5wwy0m2k 62 13 of of IN cord-015922-5wwy0m2k 62 14 fluoroquinolones fluoroquinolone NNS cord-015922-5wwy0m2k 62 15 , , , cord-015922-5wwy0m2k 62 16 with with IN cord-015922-5wwy0m2k 62 17 their -PRON- PRP$ cord-015922-5wwy0m2k 62 18 potent potent JJ cord-015922-5wwy0m2k 62 19 activity activity NN cord-015922-5wwy0m2k 62 20 against against IN cord-015922-5wwy0m2k 62 21 gram gram NN cord-015922-5wwy0m2k 62 22 - - HYPH cord-015922-5wwy0m2k 62 23 negative negative JJ cord-015922-5wwy0m2k 62 24 bacteria bacteria NNS cord-015922-5wwy0m2k 62 25 , , , cord-015922-5wwy0m2k 62 26 as as IN cord-015922-5wwy0m2k 62 27 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 62 28 during during IN cord-015922-5wwy0m2k 62 29 this this DT cord-015922-5wwy0m2k 62 30 period period NN cord-015922-5wwy0m2k 62 31 ; ; : cord-015922-5wwy0m2k 62 32 the the DT cord-015922-5wwy0m2k 62 33 presence presence NN cord-015922-5wwy0m2k 62 34 of of IN cord-015922-5wwy0m2k 62 35 indwelling indwell VBG cord-015922-5wwy0m2k 62 36 central central JJ cord-015922-5wwy0m2k 62 37 venous venous JJ cord-015922-5wwy0m2k 62 38 catheters catheter NNS cord-015922-5wwy0m2k 62 39 for for IN cord-015922-5wwy0m2k 62 40 prolonged prolonged JJ cord-015922-5wwy0m2k 62 41 periods period NNS cord-015922-5wwy0m2k 62 42 ; ; : cord-015922-5wwy0m2k 62 43 and and CC cord-015922-5wwy0m2k 62 44 the the DT cord-015922-5wwy0m2k 62 45 widespread widespread JJ cord-015922-5wwy0m2k 62 46 use use NN cord-015922-5wwy0m2k 62 47 of of IN cord-015922-5wwy0m2k 62 48 systemic systemic JJ cord-015922-5wwy0m2k 62 49 anti anti JJ cord-015922-5wwy0m2k 62 50 - - JJ cord-015922-5wwy0m2k 62 51 gram gram JJ cord-015922-5wwy0m2k 62 52 - - HYPH cord-015922-5wwy0m2k 62 53 negative negative JJ cord-015922-5wwy0m2k 62 54 therapy therapy NN cord-015922-5wwy0m2k 62 55 all all DT cord-015922-5wwy0m2k 62 56 contribute contribute VBP cord-015922-5wwy0m2k 62 57 to to IN cord-015922-5wwy0m2k 62 58 the the DT cord-015922-5wwy0m2k 62 59 gram gram NN cord-015922-5wwy0m2k 62 60 - - HYPH cord-015922-5wwy0m2k 62 61 positive positive JJ cord-015922-5wwy0m2k 62 62 predominance predominance NN cord-015922-5wwy0m2k 62 63 . . . cord-015922-5wwy0m2k 63 1 The the DT cord-015922-5wwy0m2k 63 2 bacteria bacteria NNS cord-015922-5wwy0m2k 63 3 isolated isolate VBN cord-015922-5wwy0m2k 63 4 during during IN cord-015922-5wwy0m2k 63 5 the the DT cord-015922-5wwy0m2k 63 6 preengraftment preengraftment JJ cord-015922-5wwy0m2k 63 7 period period NN cord-015922-5wwy0m2k 63 8 , , , cord-015922-5wwy0m2k 63 9 then then RB cord-015922-5wwy0m2k 63 10 , , , cord-015922-5wwy0m2k 63 11 include include VBP cord-015922-5wwy0m2k 63 12 staphylococci staphylococcus NNS cord-015922-5wwy0m2k 63 13 ( ( -LRB- cord-015922-5wwy0m2k 63 14 especially especially RB cord-015922-5wwy0m2k 63 15 coagulase coagulase NN cord-015922-5wwy0m2k 63 16 - - HYPH cord-015922-5wwy0m2k 63 17 negative negative JJ cord-015922-5wwy0m2k 63 18 Staphylococcus Staphylococcus NNP cord-015922-5wwy0m2k 63 19 ) ) -RRB- cord-015922-5wwy0m2k 63 20 , , , cord-015922-5wwy0m2k 63 21 viridans viridans NNP cord-015922-5wwy0m2k 63 22 streptococci streptococcus NNS cord-015922-5wwy0m2k 63 23 , , , cord-015922-5wwy0m2k 63 24 enterococci enterococci NNP cord-015922-5wwy0m2k 63 25 and and CC cord-015922-5wwy0m2k 63 26 corynebacteria corynebacteria NNP cord-015922-5wwy0m2k 63 27 , , , cord-015922-5wwy0m2k 63 28 with with IN cord-015922-5wwy0m2k 63 29 fewer few JJR cord-015922-5wwy0m2k 63 30 isolates isolate NNS cord-015922-5wwy0m2k 63 31 of of IN cord-015922-5wwy0m2k 63 32 Enterobacteriaceae Enterobacteriaceae NNP cord-015922-5wwy0m2k 63 33 or or CC cord-015922-5wwy0m2k 63 34 Pseudomonas Pseudomonas NNP cord-015922-5wwy0m2k 63 35 aeruginosa aeruginosa NN cord-015922-5wwy0m2k 63 36 being be VBG cord-015922-5wwy0m2k 63 37 identified identify VBN cord-015922-5wwy0m2k 63 38 . . . cord-015922-5wwy0m2k 64 1 An an DT cord-015922-5wwy0m2k 64 2 increasing increase VBG cord-015922-5wwy0m2k 64 3 problem problem NN cord-015922-5wwy0m2k 64 4 in in IN cord-015922-5wwy0m2k 64 5 the the DT cord-015922-5wwy0m2k 64 6 HSCT HSCT NNP cord-015922-5wwy0m2k 64 7 population population NN cord-015922-5wwy0m2k 64 8 is be VBZ cord-015922-5wwy0m2k 64 9 antibiotic antibiotic JJ cord-015922-5wwy0m2k 64 10 resistant resistant JJ cord-015922-5wwy0m2k 64 11 organisms organism NNS cord-015922-5wwy0m2k 64 12 , , , cord-015922-5wwy0m2k 64 13 particularly particularly RB cord-015922-5wwy0m2k 64 14 vancomycin vancomycin NN cord-015922-5wwy0m2k 64 15 - - HYPH cord-015922-5wwy0m2k 64 16 resistant resistant JJ cord-015922-5wwy0m2k 64 17 enterococci enterococci NNS cord-015922-5wwy0m2k 64 18 , , , cord-015922-5wwy0m2k 64 19 methicillin methicillin NN cord-015922-5wwy0m2k 64 20 - - HYPH cord-015922-5wwy0m2k 64 21 resistant resistant JJ cord-015922-5wwy0m2k 64 22 Staphylococcus Staphylococcus NNP cord-015922-5wwy0m2k 64 23 aureus aureus NN cord-015922-5wwy0m2k 64 24 , , , cord-015922-5wwy0m2k 64 25 and and CC cord-015922-5wwy0m2k 64 26 resistant resistant JJ cord-015922-5wwy0m2k 64 27 gram gram NN cord-015922-5wwy0m2k 64 28 - - HYPH cord-015922-5wwy0m2k 64 29 negative negative JJ cord-015922-5wwy0m2k 64 30 bacilli bacilli NN cord-015922-5wwy0m2k 64 31 ( ( -LRB- cord-015922-5wwy0m2k 64 32 such such JJ cord-015922-5wwy0m2k 64 33 as as IN cord-015922-5wwy0m2k 64 34 extended extended JJ cord-015922-5wwy0m2k 64 35 spectrum spectrum NN cord-015922-5wwy0m2k 64 36 β β NN cord-015922-5wwy0m2k 64 37 - - HYPH cord-015922-5wwy0m2k 64 38 lactamase lactamase NN cord-015922-5wwy0m2k 64 39 producing produce VBG cord-015922-5wwy0m2k 64 40 Klebsiella Klebsiella NNP cord-015922-5wwy0m2k 64 41 and and CC cord-015922-5wwy0m2k 64 42 chromosomal chromosomal JJ cord-015922-5wwy0m2k 64 43 inducible inducible JJ cord-015922-5wwy0m2k 64 44 βlactamase βlactamase NN cord-015922-5wwy0m2k 64 45 producing produce VBG cord-015922-5wwy0m2k 64 46 Enterobacter Enterobacter NNP cord-015922-5wwy0m2k 64 47 species specie NNS cord-015922-5wwy0m2k 64 48 ) ) -RRB- cord-015922-5wwy0m2k 64 49 [ [ -LRB- cord-015922-5wwy0m2k 64 50 1 1 CD cord-015922-5wwy0m2k 64 51 , , , cord-015922-5wwy0m2k 64 52 4 4 CD cord-015922-5wwy0m2k 64 53 , , , cord-015922-5wwy0m2k 64 54 6 6 CD cord-015922-5wwy0m2k 64 55 , , , cord-015922-5wwy0m2k 64 56 7 7 CD cord-015922-5wwy0m2k 64 57 , , , cord-015922-5wwy0m2k 64 58 [ [ -LRB- cord-015922-5wwy0m2k 64 59 16 16 CD cord-015922-5wwy0m2k 64 60 ] ] -RRB- cord-015922-5wwy0m2k 64 61 [ [ -LRB- cord-015922-5wwy0m2k 64 62 17 17 CD cord-015922-5wwy0m2k 64 63 ] ] -RRB- cord-015922-5wwy0m2k 64 64 [ [ -LRB- cord-015922-5wwy0m2k 64 65 18 18 CD cord-015922-5wwy0m2k 64 66 ] ] -RRB- cord-015922-5wwy0m2k 64 67 [ [ -LRB- cord-015922-5wwy0m2k 64 68 19 19 CD cord-015922-5wwy0m2k 64 69 ] ] -RRB- cord-015922-5wwy0m2k 64 70 [ [ -LRB- cord-015922-5wwy0m2k 64 71 20 20 CD cord-015922-5wwy0m2k 64 72 ] ] -RRB- cord-015922-5wwy0m2k 64 73 . . . cord-015922-5wwy0m2k 65 1 The the DT cord-015922-5wwy0m2k 65 2 typical typical JJ cord-015922-5wwy0m2k 65 3 approach approach NN cord-015922-5wwy0m2k 65 4 for for IN cord-015922-5wwy0m2k 65 5 the the DT cord-015922-5wwy0m2k 65 6 severely severely RB cord-015922-5wwy0m2k 65 7 granulocytopenic granulocytopenic JJ cord-015922-5wwy0m2k 65 8 patient patient NN cord-015922-5wwy0m2k 65 9 at at IN cord-015922-5wwy0m2k 65 10 present present NN cord-015922-5wwy0m2k 65 11 is be VBZ cord-015922-5wwy0m2k 65 12 the the DT cord-015922-5wwy0m2k 65 13 initiation initiation NN cord-015922-5wwy0m2k 65 14 of of IN cord-015922-5wwy0m2k 65 15 empiric empiric JJ cord-015922-5wwy0m2k 65 16 antibacterial antibacterial JJ cord-015922-5wwy0m2k 65 17 therapy therapy NN cord-015922-5wwy0m2k 65 18 in in IN cord-015922-5wwy0m2k 65 19 response response NN cord-015922-5wwy0m2k 65 20 to to IN cord-015922-5wwy0m2k 65 21 an an DT cord-015922-5wwy0m2k 65 22 unexplained unexplained JJ cord-015922-5wwy0m2k 65 23 fever fever NN cord-015922-5wwy0m2k 65 24 or or CC cord-015922-5wwy0m2k 65 25 other other JJ cord-015922-5wwy0m2k 65 26 signs sign NNS cord-015922-5wwy0m2k 65 27 of of IN cord-015922-5wwy0m2k 65 28 sepsis sepsis NN cord-015922-5wwy0m2k 65 29 . . . cord-015922-5wwy0m2k 66 1 What what WP cord-015922-5wwy0m2k 66 2 remains remain VBZ cord-015922-5wwy0m2k 66 3 controversial controversial JJ cord-015922-5wwy0m2k 66 4 is be VBZ cord-015922-5wwy0m2k 66 5 what what WP cord-015922-5wwy0m2k 66 6 the the DT cord-015922-5wwy0m2k 66 7 regimen regimen NN cord-015922-5wwy0m2k 66 8 should should MD cord-015922-5wwy0m2k 66 9 be be VB cord-015922-5wwy0m2k 66 10 . . . cord-015922-5wwy0m2k 67 1 Since since IN cord-015922-5wwy0m2k 67 2 clinical clinical JJ cord-015922-5wwy0m2k 67 3 deterioration deterioration NN cord-015922-5wwy0m2k 67 4 can can MD cord-015922-5wwy0m2k 67 5 occur occur VB cord-015922-5wwy0m2k 67 6 rapidly rapidly RB cord-015922-5wwy0m2k 67 7 with with IN cord-015922-5wwy0m2k 67 8 untreated untreated JJ cord-015922-5wwy0m2k 67 9 gram gram NN cord-015922-5wwy0m2k 67 10 - - HYPH cord-015922-5wwy0m2k 67 11 negative negative JJ cord-015922-5wwy0m2k 67 12 sepsis sepsis NN cord-015922-5wwy0m2k 67 13 in in IN cord-015922-5wwy0m2k 67 14 the the DT cord-015922-5wwy0m2k 67 15 granulocytopenic granulocytopenic NNP cord-015922-5wwy0m2k 67 16 patient patient NN cord-015922-5wwy0m2k 67 17 , , , cord-015922-5wwy0m2k 67 18 anti anti JJ cord-015922-5wwy0m2k 67 19 - - JJ cord-015922-5wwy0m2k 67 20 gramnegative gramnegative JJ cord-015922-5wwy0m2k 67 21 therapy therapy NN cord-015922-5wwy0m2k 67 22 is be VBZ cord-015922-5wwy0m2k 67 23 always always RB cord-015922-5wwy0m2k 67 24 employed employ VBN cord-015922-5wwy0m2k 67 25 . . . cord-015922-5wwy0m2k 68 1 The the DT cord-015922-5wwy0m2k 68 2 traditional traditional JJ cord-015922-5wwy0m2k 68 3 approach approach NN cord-015922-5wwy0m2k 68 4 of of IN cord-015922-5wwy0m2k 68 5 a a DT cord-015922-5wwy0m2k 68 6 β β NN cord-015922-5wwy0m2k 68 7 - - HYPH cord-015922-5wwy0m2k 68 8 lactam lactam NNP cord-015922-5wwy0m2k 68 9 ( ( -LRB- cord-015922-5wwy0m2k 68 10 e.g. e.g. RB cord-015922-5wwy0m2k 68 11 , , , cord-015922-5wwy0m2k 68 12 piperacillin piperacillin NNP cord-015922-5wwy0m2k 68 13 ) ) -RRB- cord-015922-5wwy0m2k 68 14 plus plus CC cord-015922-5wwy0m2k 68 15 an an DT cord-015922-5wwy0m2k 68 16 aminoglycoside aminoglycoside NN cord-015922-5wwy0m2k 68 17 is be VBZ cord-015922-5wwy0m2k 68 18 still still RB cord-015922-5wwy0m2k 68 19 favored favor VBN cord-015922-5wwy0m2k 68 20 by by IN cord-015922-5wwy0m2k 68 21 some some DT cord-015922-5wwy0m2k 68 22 experts expert NNS cord-015922-5wwy0m2k 68 23 , , , cord-015922-5wwy0m2k 68 24 although although IN cord-015922-5wwy0m2k 68 25 nephrotoxicity nephrotoxicity NN cord-015922-5wwy0m2k 68 26 from from IN cord-015922-5wwy0m2k 68 27 the the DT cord-015922-5wwy0m2k 68 28 aminoglycoside aminoglycoside NNP cord-015922-5wwy0m2k 68 29 has have VBZ cord-015922-5wwy0m2k 68 30 led lead VBN cord-015922-5wwy0m2k 68 31 to to IN cord-015922-5wwy0m2k 68 32 the the DT cord-015922-5wwy0m2k 68 33 trial trial NN cord-015922-5wwy0m2k 68 34 of of IN cord-015922-5wwy0m2k 68 35 other other JJ cord-015922-5wwy0m2k 68 36 approaches approach NNS cord-015922-5wwy0m2k 68 37 , , , cord-015922-5wwy0m2k 68 38 including include VBG cord-015922-5wwy0m2k 68 39 the the DT cord-015922-5wwy0m2k 68 40 substitution substitution NN cord-015922-5wwy0m2k 68 41 of of IN cord-015922-5wwy0m2k 68 42 a a DT cord-015922-5wwy0m2k 68 43 fluoroquinolone fluoroquinolone NN cord-015922-5wwy0m2k 68 44 for for IN cord-015922-5wwy0m2k 68 45 the the DT cord-015922-5wwy0m2k 68 46 aminoglycoside aminoglycoside NN cord-015922-5wwy0m2k 68 47 , , , cord-015922-5wwy0m2k 68 48 or or CC cord-015922-5wwy0m2k 68 49 the the DT cord-015922-5wwy0m2k 68 50 prescription prescription NN cord-015922-5wwy0m2k 68 51 of of IN cord-015922-5wwy0m2k 68 52 a a DT cord-015922-5wwy0m2k 68 53 single single JJ cord-015922-5wwy0m2k 68 54 advanced advanced JJ cord-015922-5wwy0m2k 68 55 spectrum spectrum NN cord-015922-5wwy0m2k 68 56 drug drug NN cord-015922-5wwy0m2k 68 57 such such JJ cord-015922-5wwy0m2k 68 58 as as IN cord-015922-5wwy0m2k 68 59 ceftazidime ceftazidime NNP cord-015922-5wwy0m2k 68 60 , , , cord-015922-5wwy0m2k 68 61 cefepime cefepime NNP cord-015922-5wwy0m2k 68 62 , , , cord-015922-5wwy0m2k 68 63 imipenem imipenem NNP cord-015922-5wwy0m2k 68 64 or or CC cord-015922-5wwy0m2k 68 65 meropenem meropenem NNP cord-015922-5wwy0m2k 68 66 . . . cord-015922-5wwy0m2k 69 1 If if IN cord-015922-5wwy0m2k 69 2 fluoroquinolone fluoroquinolone NN cord-015922-5wwy0m2k 69 3 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 69 4 has have VBZ cord-015922-5wwy0m2k 69 5 been be VBN cord-015922-5wwy0m2k 69 6 utilized utilize VBN cord-015922-5wwy0m2k 69 7 , , , cord-015922-5wwy0m2k 69 8 then then RB cord-015922-5wwy0m2k 69 9 its -PRON- PRP$ cord-015922-5wwy0m2k 69 10 use use NN cord-015922-5wwy0m2k 69 11 as as IN cord-015922-5wwy0m2k 69 12 a a DT cord-015922-5wwy0m2k 69 13 therapeutic therapeutic JJ cord-015922-5wwy0m2k 69 14 agent agent NN cord-015922-5wwy0m2k 69 15 may may MD cord-015922-5wwy0m2k 69 16 be be VB cord-015922-5wwy0m2k 69 17 diminished diminish VBN cord-015922-5wwy0m2k 69 18 . . . cord-015922-5wwy0m2k 70 1 Empiric empiric NN cord-015922-5wwy0m2k 70 2 fluoroquinolone fluoroquinolone NN cord-015922-5wwy0m2k 70 3 monotherapy monotherapy NN cord-015922-5wwy0m2k 70 4 is be VBZ cord-015922-5wwy0m2k 70 5 inferior inferior JJ cord-015922-5wwy0m2k 70 6 to to IN cord-015922-5wwy0m2k 70 7 other other JJ cord-015922-5wwy0m2k 70 8 regimens regimen NNS cord-015922-5wwy0m2k 70 9 , , , cord-015922-5wwy0m2k 70 10 and and CC cord-015922-5wwy0m2k 70 11 if if IN cord-015922-5wwy0m2k 70 12 pure pure JJ cord-015922-5wwy0m2k 70 13 aerobic aerobic JJ cord-015922-5wwy0m2k 70 14 gram gram NN cord-015922-5wwy0m2k 70 15 - - HYPH cord-015922-5wwy0m2k 70 16 negative negative JJ cord-015922-5wwy0m2k 70 17 agents agent NNS cord-015922-5wwy0m2k 70 18 are be VBP cord-015922-5wwy0m2k 70 19 utilized utilize VBN cord-015922-5wwy0m2k 70 20 , , , cord-015922-5wwy0m2k 70 21 ( ( -LRB- cord-015922-5wwy0m2k 70 22 e.g. e.g. RB cord-015922-5wwy0m2k 70 23 , , , cord-015922-5wwy0m2k 70 24 aztreonam aztreonam NN cord-015922-5wwy0m2k 70 25 , , , cord-015922-5wwy0m2k 70 26 aminoglycosides aminoglycoside NNS cord-015922-5wwy0m2k 70 27 ) ) -RRB- cord-015922-5wwy0m2k 70 28 due due JJ cord-015922-5wwy0m2k 70 29 to to IN cord-015922-5wwy0m2k 70 30 confirmed confirm VBN cord-015922-5wwy0m2k 70 31 severe severe JJ cord-015922-5wwy0m2k 70 32 beta beta NN cord-015922-5wwy0m2k 70 33 - - HYPH cord-015922-5wwy0m2k 70 34 lactam lactam NN cord-015922-5wwy0m2k 70 35 hypersensitivity hypersensitivity NN cord-015922-5wwy0m2k 70 36 , , , cord-015922-5wwy0m2k 70 37 then then RB cord-015922-5wwy0m2k 70 38 the the DT cord-015922-5wwy0m2k 70 39 addition addition NN cord-015922-5wwy0m2k 70 40 of of IN cord-015922-5wwy0m2k 70 41 empiric empiric JJ cord-015922-5wwy0m2k 70 42 gram gram NN cord-015922-5wwy0m2k 70 43 - - HYPH cord-015922-5wwy0m2k 70 44 positive positive JJ cord-015922-5wwy0m2k 70 45 coverage coverage NN cord-015922-5wwy0m2k 70 46 that that WDT cord-015922-5wwy0m2k 70 47 targets target VBZ cord-015922-5wwy0m2k 70 48 aerobic aerobic JJ cord-015922-5wwy0m2k 70 49 and and CC cord-015922-5wwy0m2k 70 50 anaerobic anaerobic JJ cord-015922-5wwy0m2k 70 51 streptococci streptococcus NNS cord-015922-5wwy0m2k 70 52 of of IN cord-015922-5wwy0m2k 70 53 the the DT cord-015922-5wwy0m2k 70 54 gastrointestinal gastrointestinal JJ cord-015922-5wwy0m2k 70 55 tract tract NN cord-015922-5wwy0m2k 70 56 should should MD cord-015922-5wwy0m2k 70 57 be be VB cord-015922-5wwy0m2k 70 58 considered consider VBN cord-015922-5wwy0m2k 70 59 . . . cord-015922-5wwy0m2k 71 1 Use use NN cord-015922-5wwy0m2k 71 2 of of IN cord-015922-5wwy0m2k 71 3 extended extended JJ cord-015922-5wwy0m2k 71 4 interval interval NN cord-015922-5wwy0m2k 71 5 ( ( -LRB- cord-015922-5wwy0m2k 71 6 once once RB cord-015922-5wwy0m2k 71 7 - - HYPH cord-015922-5wwy0m2k 71 8 daily daily NN cord-015922-5wwy0m2k 71 9 dosing dosing NN cord-015922-5wwy0m2k 71 10 ) ) -RRB- cord-015922-5wwy0m2k 72 1 aminoglycoside aminoglycoside NNP cord-015922-5wwy0m2k 72 2 administration administration NN cord-015922-5wwy0m2k 72 3 may may MD cord-015922-5wwy0m2k 72 4 be be VB cord-015922-5wwy0m2k 72 5 safer safe JJR cord-015922-5wwy0m2k 72 6 and and CC cord-015922-5wwy0m2k 72 7 as as IN cord-015922-5wwy0m2k 72 8 effective effective JJ cord-015922-5wwy0m2k 72 9 . . . cord-015922-5wwy0m2k 73 1 The the DT cord-015922-5wwy0m2k 73 2 second second JJ cord-015922-5wwy0m2k 73 3 area area NN cord-015922-5wwy0m2k 73 4 of of IN cord-015922-5wwy0m2k 73 5 controversy controversy NN cord-015922-5wwy0m2k 73 6 is be VBZ cord-015922-5wwy0m2k 73 7 whether whether IN cord-015922-5wwy0m2k 73 8 empiric empiric JJ cord-015922-5wwy0m2k 73 9 gram gram NN cord-015922-5wwy0m2k 73 10 - - HYPH cord-015922-5wwy0m2k 73 11 positive positive JJ cord-015922-5wwy0m2k 73 12 treatment treatment NN cord-015922-5wwy0m2k 73 13 should should MD cord-015922-5wwy0m2k 73 14 be be VB cord-015922-5wwy0m2k 73 15 initiated initiate VBN cord-015922-5wwy0m2k 73 16 at at IN cord-015922-5wwy0m2k 73 17 the the DT cord-015922-5wwy0m2k 73 18 same same JJ cord-015922-5wwy0m2k 73 19 time time NN cord-015922-5wwy0m2k 73 20 , , , cord-015922-5wwy0m2k 73 21 given give VBN cord-015922-5wwy0m2k 73 22 the the DT cord-015922-5wwy0m2k 73 23 preponderance preponderance NN cord-015922-5wwy0m2k 73 24 of of IN cord-015922-5wwy0m2k 73 25 grampositive grampositive JJ cord-015922-5wwy0m2k 73 26 infection infection NN cord-015922-5wwy0m2k 73 27 . . . cord-015922-5wwy0m2k 74 1 As as IN cord-015922-5wwy0m2k 74 2 there there EX cord-015922-5wwy0m2k 74 3 is be VBZ cord-015922-5wwy0m2k 74 4 typically typically RB cord-015922-5wwy0m2k 74 5 time time NN cord-015922-5wwy0m2k 74 6 to to TO cord-015922-5wwy0m2k 74 7 evaluate evaluate VB cord-015922-5wwy0m2k 74 8 culture culture NN cord-015922-5wwy0m2k 74 9 data datum NNS cord-015922-5wwy0m2k 74 10 and and CC cord-015922-5wwy0m2k 74 11 deploy deploy VB cord-015922-5wwy0m2k 74 12 targeted target VBN cord-015922-5wwy0m2k 74 13 gram gram NN cord-015922-5wwy0m2k 74 14 - - HYPH cord-015922-5wwy0m2k 74 15 positive positive JJ cord-015922-5wwy0m2k 74 16 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 74 17 therapy therapy NN cord-015922-5wwy0m2k 74 18 rather rather RB cord-015922-5wwy0m2k 74 19 than than IN cord-015922-5wwy0m2k 74 20 empiricism empiricism NN cord-015922-5wwy0m2k 74 21 , , , cord-015922-5wwy0m2k 74 22 vancomycin vancomycin NN cord-015922-5wwy0m2k 74 23 should should MD cord-015922-5wwy0m2k 74 24 rarely rarely RB cord-015922-5wwy0m2k 74 25 be be VB cord-015922-5wwy0m2k 74 26 required require VBN cord-015922-5wwy0m2k 74 27 empirically empirically RB cord-015922-5wwy0m2k 74 28 . . . cord-015922-5wwy0m2k 75 1 Furthermore furthermore RB cord-015922-5wwy0m2k 75 2 , , , cord-015922-5wwy0m2k 75 3 empiric empiric JJ cord-015922-5wwy0m2k 75 4 gram gram NN cord-015922-5wwy0m2k 75 5 - - HYPH cord-015922-5wwy0m2k 75 6 positive positive JJ cord-015922-5wwy0m2k 75 7 coverage coverage NN cord-015922-5wwy0m2k 75 8 is be VBZ cord-015922-5wwy0m2k 75 9 not not RB cord-015922-5wwy0m2k 75 10 associated associate VBN cord-015922-5wwy0m2k 75 11 with with IN cord-015922-5wwy0m2k 75 12 better well JJR cord-015922-5wwy0m2k 75 13 outcomes outcome NNS cord-015922-5wwy0m2k 75 14 [ [ -LRB- cord-015922-5wwy0m2k 75 15 21 21 CD cord-015922-5wwy0m2k 75 16 ] ] -RRB- cord-015922-5wwy0m2k 75 17 . . . cord-015922-5wwy0m2k 76 1 Indications indication NNS cord-015922-5wwy0m2k 76 2 for for IN cord-015922-5wwy0m2k 76 3 the the DT cord-015922-5wwy0m2k 76 4 immediate immediate JJ cord-015922-5wwy0m2k 76 5 initiation initiation NN cord-015922-5wwy0m2k 76 6 of of IN cord-015922-5wwy0m2k 76 7 vancomycin vancomycin NN cord-015922-5wwy0m2k 76 8 as as IN cord-015922-5wwy0m2k 76 9 part part NN cord-015922-5wwy0m2k 76 10 of of IN cord-015922-5wwy0m2k 76 11 the the DT cord-015922-5wwy0m2k 76 12 empiric empiric JJ cord-015922-5wwy0m2k 76 13 therapy therapy NN cord-015922-5wwy0m2k 76 14 regimen regimen NN cord-015922-5wwy0m2k 76 15 include include VBP cord-015922-5wwy0m2k 76 16 the the DT cord-015922-5wwy0m2k 76 17 following follow VBG cord-015922-5wwy0m2k 76 18 [ [ -LRB- cord-015922-5wwy0m2k 76 19 6 6 CD cord-015922-5wwy0m2k 76 20 , , , cord-015922-5wwy0m2k 76 21 16 16 CD cord-015922-5wwy0m2k 76 22 , , , cord-015922-5wwy0m2k 76 23 [ [ -LRB- cord-015922-5wwy0m2k 76 24 18 18 CD cord-015922-5wwy0m2k 76 25 ] ] -RRB- cord-015922-5wwy0m2k 76 26 [ [ -LRB- cord-015922-5wwy0m2k 76 27 19 19 CD cord-015922-5wwy0m2k 76 28 ] ] -RRB- cord-015922-5wwy0m2k 76 29 [ [ -LRB- cord-015922-5wwy0m2k 76 30 20 20 CD cord-015922-5wwy0m2k 76 31 ] ] -RRB- cord-015922-5wwy0m2k 76 32 [ [ -LRB- cord-015922-5wwy0m2k 76 33 21 21 CD cord-015922-5wwy0m2k 76 34 ] ] -RRB- cord-015922-5wwy0m2k 76 35 : : : cord-015922-5wwy0m2k 76 36 catheter catheter NN cord-015922-5wwy0m2k 76 37 - - HYPH cord-015922-5wwy0m2k 76 38 related relate VBN cord-015922-5wwy0m2k 76 39 sepsis sepsis NN cord-015922-5wwy0m2k 76 40 is be VBZ cord-015922-5wwy0m2k 76 41 likely likely JJ cord-015922-5wwy0m2k 76 42 because because IN cord-015922-5wwy0m2k 76 43 of of IN cord-015922-5wwy0m2k 76 44 evidence evidence NN cord-015922-5wwy0m2k 76 45 of of IN cord-015922-5wwy0m2k 76 46 infection infection NN cord-015922-5wwy0m2k 76 47 at at IN cord-015922-5wwy0m2k 76 48 the the DT cord-015922-5wwy0m2k 76 49 insertion insertion NN cord-015922-5wwy0m2k 76 50 site site NN cord-015922-5wwy0m2k 76 51 ( ( -LRB- cord-015922-5wwy0m2k 76 52 or or CC cord-015922-5wwy0m2k 76 53 within within IN cord-015922-5wwy0m2k 76 54 the the DT cord-015922-5wwy0m2k 76 55 tunnel tunnel NN cord-015922-5wwy0m2k 76 56 ) ) -RRB- cord-015922-5wwy0m2k 76 57 , , , cord-015922-5wwy0m2k 76 58 severe severe JJ cord-015922-5wwy0m2k 76 59 illness illness NN cord-015922-5wwy0m2k 76 60 such such JJ cord-015922-5wwy0m2k 76 61 as as IN cord-015922-5wwy0m2k 76 62 shock shock NN cord-015922-5wwy0m2k 76 63 and/or and/or CC cord-015922-5wwy0m2k 76 64 respiratory respiratory JJ cord-015922-5wwy0m2k 76 65 distress distress NN cord-015922-5wwy0m2k 76 66 are be VBP cord-015922-5wwy0m2k 76 67 present present JJ cord-015922-5wwy0m2k 76 68 , , , cord-015922-5wwy0m2k 76 69 the the DT cord-015922-5wwy0m2k 76 70 patient patient NN cord-015922-5wwy0m2k 76 71 is be VBZ cord-015922-5wwy0m2k 76 72 at at IN cord-015922-5wwy0m2k 76 73 particular particular JJ cord-015922-5wwy0m2k 76 74 risk risk NN cord-015922-5wwy0m2k 76 75 for for IN cord-015922-5wwy0m2k 76 76 seeding seeding NN cord-015922-5wwy0m2k 76 77 of of IN cord-015922-5wwy0m2k 76 78 a a DT cord-015922-5wwy0m2k 76 79 prosthetic prosthetic JJ cord-015922-5wwy0m2k 76 80 device device NN cord-015922-5wwy0m2k 76 81 ( ( -LRB- cord-015922-5wwy0m2k 76 82 e.g. e.g. RB cord-015922-5wwy0m2k 76 83 , , , cord-015922-5wwy0m2k 76 84 a a DT cord-015922-5wwy0m2k 76 85 prosthetic prosthetic JJ cord-015922-5wwy0m2k 76 86 valve valve NN cord-015922-5wwy0m2k 76 87 , , , cord-015922-5wwy0m2k 76 88 a a DT cord-015922-5wwy0m2k 76 89 hip hip NN cord-015922-5wwy0m2k 76 90 prosthesis prosthesis NN cord-015922-5wwy0m2k 76 91 , , , cord-015922-5wwy0m2k 76 92 etc etc FW cord-015922-5wwy0m2k 76 93 . . . cord-015922-5wwy0m2k 76 94 ) ) -RRB- cord-015922-5wwy0m2k 76 95 , , , cord-015922-5wwy0m2k 76 96 or or CC cord-015922-5wwy0m2k 76 97 the the DT cord-015922-5wwy0m2k 76 98 empiric empiric JJ cord-015922-5wwy0m2k 76 99 gram gram NN cord-015922-5wwy0m2k 76 100 - - HYPH cord-015922-5wwy0m2k 76 101 negative negative JJ cord-015922-5wwy0m2k 76 102 coverage coverage NN cord-015922-5wwy0m2k 76 103 exclusively exclusively RB cord-015922-5wwy0m2k 76 104 covers cover VBZ cord-015922-5wwy0m2k 76 105 aerobic aerobic JJ cord-015922-5wwy0m2k 76 106 gram gram NN cord-015922-5wwy0m2k 76 107 - - HYPH cord-015922-5wwy0m2k 76 108 negative negative JJ cord-015922-5wwy0m2k 76 109 rods rod NNS cord-015922-5wwy0m2k 76 110 -such -such : cord-015922-5wwy0m2k 76 111 as as IN cord-015922-5wwy0m2k 76 112 the the DT cord-015922-5wwy0m2k 76 113 combination combination NN cord-015922-5wwy0m2k 76 114 of of IN cord-015922-5wwy0m2k 76 115 aztreonam aztreonam NN cord-015922-5wwy0m2k 76 116 and and CC cord-015922-5wwy0m2k 76 117 gentamicin gentamicin NNP cord-015922-5wwy0m2k 76 118 . . . cord-015922-5wwy0m2k 77 1 Vancomycin Vancomycin NNP cord-015922-5wwy0m2k 77 2 or or CC cord-015922-5wwy0m2k 77 3 other other JJ cord-015922-5wwy0m2k 77 4 anti anti JJ cord-015922-5wwy0m2k 77 5 - - JJ cord-015922-5wwy0m2k 77 6 staphylococcal staphylococcal JJ cord-015922-5wwy0m2k 77 7 agents agent NNS cord-015922-5wwy0m2k 77 8 should should MD cord-015922-5wwy0m2k 77 9 be be VB cord-015922-5wwy0m2k 77 10 started start VBN cord-015922-5wwy0m2k 77 11 if if IN cord-015922-5wwy0m2k 77 12 cultures culture NNS cord-015922-5wwy0m2k 77 13 become become VBP cord-015922-5wwy0m2k 77 14 positive positive JJ cord-015922-5wwy0m2k 77 15 for for IN cord-015922-5wwy0m2k 77 16 gram gram NN cord-015922-5wwy0m2k 77 17 - - HYPH cord-015922-5wwy0m2k 77 18 positive positive JJ cord-015922-5wwy0m2k 77 19 cocci coccus NNS cord-015922-5wwy0m2k 77 20 . . . cord-015922-5wwy0m2k 78 1 In in IN cord-015922-5wwy0m2k 78 2 our -PRON- PRP$ cord-015922-5wwy0m2k 78 3 experience experience NN cord-015922-5wwy0m2k 78 4 , , , cord-015922-5wwy0m2k 78 5 vancomycin vancomycin FW cord-015922-5wwy0m2k 78 6 can can MD cord-015922-5wwy0m2k 78 7 be be VB cord-015922-5wwy0m2k 78 8 discontinued discontinue VBN cord-015922-5wwy0m2k 78 9 safely safely RB cord-015922-5wwy0m2k 78 10 in in IN cord-015922-5wwy0m2k 78 11 patients patient NNS cord-015922-5wwy0m2k 78 12 in in IN cord-015922-5wwy0m2k 78 13 whom whom WP cord-015922-5wwy0m2k 78 14 vancomycin vancomycin NNP cord-015922-5wwy0m2k 78 15 was be VBD cord-015922-5wwy0m2k 78 16 started start VBN cord-015922-5wwy0m2k 78 17 empirically empirically RB cord-015922-5wwy0m2k 78 18 , , , cord-015922-5wwy0m2k 78 19 but but CC cord-015922-5wwy0m2k 78 20 in in IN cord-015922-5wwy0m2k 78 21 whom whom WP cord-015922-5wwy0m2k 78 22 blood blood NN cord-015922-5wwy0m2k 78 23 cultures culture NNS cord-015922-5wwy0m2k 78 24 remain remain VBP cord-015922-5wwy0m2k 78 25 negative negative JJ cord-015922-5wwy0m2k 78 26 after after IN cord-015922-5wwy0m2k 78 27 48 48 CD cord-015922-5wwy0m2k 78 28 to to TO cord-015922-5wwy0m2k 78 29 72 72 CD cord-015922-5wwy0m2k 78 30 hours hour NNS cord-015922-5wwy0m2k 78 31 and and CC cord-015922-5wwy0m2k 78 32 there there EX cord-015922-5wwy0m2k 78 33 is be VBZ cord-015922-5wwy0m2k 78 34 no no DT cord-015922-5wwy0m2k 78 35 specific specific JJ cord-015922-5wwy0m2k 78 36 syndrome syndrome NN cord-015922-5wwy0m2k 78 37 , , , cord-015922-5wwy0m2k 78 38 such such JJ cord-015922-5wwy0m2k 78 39 as as IN cord-015922-5wwy0m2k 78 40 cellulitis cellulitis NN cord-015922-5wwy0m2k 78 41 , , , cord-015922-5wwy0m2k 78 42 that that WDT cord-015922-5wwy0m2k 78 43 requires require VBZ cord-015922-5wwy0m2k 78 44 treatment treatment NN cord-015922-5wwy0m2k 78 45 with with IN cord-015922-5wwy0m2k 78 46 vancomycin vancomycin NNS cord-015922-5wwy0m2k 78 47 . . . cord-015922-5wwy0m2k 79 1 On on IN cord-015922-5wwy0m2k 79 2 the the DT cord-015922-5wwy0m2k 79 3 other other JJ cord-015922-5wwy0m2k 79 4 hand hand NN cord-015922-5wwy0m2k 79 5 , , , cord-015922-5wwy0m2k 79 6 empirical empirical JJ cord-015922-5wwy0m2k 79 7 treatment treatment NN cord-015922-5wwy0m2k 79 8 against against IN cord-015922-5wwy0m2k 79 9 gram gram NN cord-015922-5wwy0m2k 79 10 - - HYPH cord-015922-5wwy0m2k 79 11 negative negative JJ cord-015922-5wwy0m2k 79 12 organisms organism NNS cord-015922-5wwy0m2k 79 13 should should MD cord-015922-5wwy0m2k 79 14 be be VB cord-015922-5wwy0m2k 79 15 continued continue VBN cord-015922-5wwy0m2k 79 16 until until IN cord-015922-5wwy0m2k 79 17 resolution resolution NN cord-015922-5wwy0m2k 79 18 of of IN cord-015922-5wwy0m2k 79 19 neutropenia neutropenia NN cord-015922-5wwy0m2k 79 20 , , , cord-015922-5wwy0m2k 79 21 whether whether IN cord-015922-5wwy0m2k 79 22 fevers fever NNS cord-015922-5wwy0m2k 79 23 resolve resolve VBP cord-015922-5wwy0m2k 79 24 or or CC cord-015922-5wwy0m2k 79 25 not not RB cord-015922-5wwy0m2k 79 26 [ [ -LRB- cord-015922-5wwy0m2k 79 27 22 22 CD cord-015922-5wwy0m2k 79 28 ] ] -RRB- cord-015922-5wwy0m2k 79 29 . . . cord-015922-5wwy0m2k 80 1 The the DT cord-015922-5wwy0m2k 80 2 emergence emergence NN cord-015922-5wwy0m2k 80 3 and and CC cord-015922-5wwy0m2k 80 4 persistence persistence NN cord-015922-5wwy0m2k 80 5 of of IN cord-015922-5wwy0m2k 80 6 multidrug multidrug NN cord-015922-5wwy0m2k 80 7 - - HYPH cord-015922-5wwy0m2k 80 8 resistant resistant JJ cord-015922-5wwy0m2k 80 9 organisms organism NNS cord-015922-5wwy0m2k 80 10 should should MD cord-015922-5wwy0m2k 80 11 guide guide VB cord-015922-5wwy0m2k 80 12 local local JJ cord-015922-5wwy0m2k 80 13 practice practice NN cord-015922-5wwy0m2k 80 14 in in IN cord-015922-5wwy0m2k 80 15 a a DT cord-015922-5wwy0m2k 80 16 dynamic dynamic JJ cord-015922-5wwy0m2k 80 17 fashion fashion NN cord-015922-5wwy0m2k 80 18 . . . cord-015922-5wwy0m2k 81 1 Indwelling indwell VBG cord-015922-5wwy0m2k 81 2 long long JJ cord-015922-5wwy0m2k 81 3 - - HYPH cord-015922-5wwy0m2k 81 4 term term NN cord-015922-5wwy0m2k 81 5 catheters catheter NNS cord-015922-5wwy0m2k 81 6 remain remain VBP cord-015922-5wwy0m2k 81 7 a a DT cord-015922-5wwy0m2k 81 8 feature feature NN cord-015922-5wwy0m2k 81 9 of of IN cord-015922-5wwy0m2k 81 10 the the DT cord-015922-5wwy0m2k 81 11 early early JJ cord-015922-5wwy0m2k 81 12 post post JJ cord-015922-5wwy0m2k 81 13 - - JJ cord-015922-5wwy0m2k 81 14 transplant transplant JJ cord-015922-5wwy0m2k 81 15 period period NN cord-015922-5wwy0m2k 81 16 to to TO cord-015922-5wwy0m2k 81 17 provide provide VB cord-015922-5wwy0m2k 81 18 chemotherapy chemotherapy NN cord-015922-5wwy0m2k 81 19 , , , cord-015922-5wwy0m2k 81 20 nutritional nutritional JJ cord-015922-5wwy0m2k 81 21 and and CC cord-015922-5wwy0m2k 81 22 blood blood NN cord-015922-5wwy0m2k 81 23 product product NN cord-015922-5wwy0m2k 81 24 support support NN cord-015922-5wwy0m2k 81 25 until until IN cord-015922-5wwy0m2k 81 26 stable stable JJ cord-015922-5wwy0m2k 81 27 engraftment engraftment NN cord-015922-5wwy0m2k 81 28 . . . cord-015922-5wwy0m2k 82 1 Routine routine JJ cord-015922-5wwy0m2k 82 2 anti anti JJ cord-015922-5wwy0m2k 82 3 - - JJ cord-015922-5wwy0m2k 82 4 gram gram JJ cord-015922-5wwy0m2k 82 5 - - HYPH cord-015922-5wwy0m2k 82 6 positive positive JJ cord-015922-5wwy0m2k 82 7 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 82 8 therapy therapy NN cord-015922-5wwy0m2k 82 9 is be VBZ cord-015922-5wwy0m2k 82 10 not not RB cord-015922-5wwy0m2k 82 11 required require VBN cord-015922-5wwy0m2k 82 12 just just RB cord-015922-5wwy0m2k 82 13 because because IN cord-015922-5wwy0m2k 82 14 a a DT cord-015922-5wwy0m2k 82 15 central central JJ cord-015922-5wwy0m2k 82 16 catheter catheter NN cord-015922-5wwy0m2k 82 17 is be VBZ cord-015922-5wwy0m2k 82 18 in in IN cord-015922-5wwy0m2k 82 19 place place NN cord-015922-5wwy0m2k 82 20 for for IN cord-015922-5wwy0m2k 82 21 the the DT cord-015922-5wwy0m2k 82 22 prevention prevention NN cord-015922-5wwy0m2k 82 23 and and CC cord-015922-5wwy0m2k 82 24 management management NN cord-015922-5wwy0m2k 82 25 of of IN cord-015922-5wwy0m2k 82 26 catheter catheter NN cord-015922-5wwy0m2k 82 27 - - HYPH cord-015922-5wwy0m2k 82 28 related relate VBN cord-015922-5wwy0m2k 82 29 infections infection NNS cord-015922-5wwy0m2k 82 30 [ [ -LRB- cord-015922-5wwy0m2k 82 31 21 21 CD cord-015922-5wwy0m2k 82 32 , , , cord-015922-5wwy0m2k 82 33 23 23 CD cord-015922-5wwy0m2k 82 34 ] ] -RRB- cord-015922-5wwy0m2k 82 35 . . . cord-015922-5wwy0m2k 83 1 The the DT cord-015922-5wwy0m2k 83 2 use use NN cord-015922-5wwy0m2k 83 3 of of IN cord-015922-5wwy0m2k 83 4 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 83 5 - - HYPH cord-015922-5wwy0m2k 83 6 coated coated JJ cord-015922-5wwy0m2k 83 7 catheters catheter NNS cord-015922-5wwy0m2k 83 8 should should MD cord-015922-5wwy0m2k 83 9 be be VB cord-015922-5wwy0m2k 83 10 studied study VBN cord-015922-5wwy0m2k 83 11 in in IN cord-015922-5wwy0m2k 83 12 this this DT cord-015922-5wwy0m2k 83 13 population population NN cord-015922-5wwy0m2k 83 14 , , , cord-015922-5wwy0m2k 83 15 especially especially RB cord-015922-5wwy0m2k 83 16 when when WRB cord-015922-5wwy0m2k 83 17 non non JJ cord-015922-5wwy0m2k 83 18 - - JJ cord-015922-5wwy0m2k 83 19 tunneled tunnel VBN cord-015922-5wwy0m2k 83 20 catheters catheter NNS cord-015922-5wwy0m2k 83 21 need need VBP cord-015922-5wwy0m2k 83 22 to to TO cord-015922-5wwy0m2k 83 23 be be VB cord-015922-5wwy0m2k 83 24 used use VBN cord-015922-5wwy0m2k 83 25 . . . cord-015922-5wwy0m2k 84 1 Nonantimicrobial Nonantimicrobial NNP cord-015922-5wwy0m2k 84 2 - - HYPH cord-015922-5wwy0m2k 84 3 based base VBN cord-015922-5wwy0m2k 84 4 strategies strategy NNS cord-015922-5wwy0m2k 84 5 to to TO cord-015922-5wwy0m2k 84 6 prevent prevent VB cord-015922-5wwy0m2k 84 7 bacterial bacterial JJ cord-015922-5wwy0m2k 84 8 infections infection NNS cord-015922-5wwy0m2k 84 9 during during IN cord-015922-5wwy0m2k 84 10 the the DT cord-015922-5wwy0m2k 84 11 neutropenic neutropenic JJ cord-015922-5wwy0m2k 84 12 period period NN cord-015922-5wwy0m2k 84 13 include include VBP cord-015922-5wwy0m2k 84 14 the the DT cord-015922-5wwy0m2k 84 15 systematic systematic JJ cord-015922-5wwy0m2k 84 16 use use NN cord-015922-5wwy0m2k 84 17 of of IN cord-015922-5wwy0m2k 84 18 hand hand NN cord-015922-5wwy0m2k 84 19 hygiene hygiene NN cord-015922-5wwy0m2k 84 20 and and CC cord-015922-5wwy0m2k 84 21 the the DT cord-015922-5wwy0m2k 84 22 use use NN cord-015922-5wwy0m2k 84 23 of of IN cord-015922-5wwy0m2k 84 24 mask mask NN cord-015922-5wwy0m2k 84 25 and and CC cord-015922-5wwy0m2k 84 26 gloves glove NNS cord-015922-5wwy0m2k 84 27 by by IN cord-015922-5wwy0m2k 84 28 health health NN cord-015922-5wwy0m2k 84 29 care care NN cord-015922-5wwy0m2k 84 30 personnel personnel NNS cord-015922-5wwy0m2k 84 31 and and CC cord-015922-5wwy0m2k 84 32 family family NN cord-015922-5wwy0m2k 84 33 members member NNS cord-015922-5wwy0m2k 84 34 . . . cord-015922-5wwy0m2k 85 1 Other other JJ cord-015922-5wwy0m2k 85 2 nonantimicrobial nonantimicrobial JJ cord-015922-5wwy0m2k 85 3 strategies strategy NNS cord-015922-5wwy0m2k 85 4 which which WDT cord-015922-5wwy0m2k 85 5 may may MD cord-015922-5wwy0m2k 85 6 be be VB cord-015922-5wwy0m2k 85 7 beneficial beneficial JJ cord-015922-5wwy0m2k 85 8 in in IN cord-015922-5wwy0m2k 85 9 preventing prevent VBG cord-015922-5wwy0m2k 85 10 infections infection NNS cord-015922-5wwy0m2k 85 11 , , , cord-015922-5wwy0m2k 85 12 but but CC cord-015922-5wwy0m2k 85 13 have have VBP cord-015922-5wwy0m2k 85 14 not not RB cord-015922-5wwy0m2k 85 15 been be VBN cord-015922-5wwy0m2k 85 16 tested test VBN cord-015922-5wwy0m2k 85 17 in in IN cord-015922-5wwy0m2k 85 18 HSCT HSCT NNP cord-015922-5wwy0m2k 85 19 , , , cord-015922-5wwy0m2k 85 20 include include VBP cord-015922-5wwy0m2k 85 21 the the DT cord-015922-5wwy0m2k 85 22 use use NN cord-015922-5wwy0m2k 85 23 of of IN cord-015922-5wwy0m2k 85 24 palifermin palifermin NNP cord-015922-5wwy0m2k 85 25 to to TO cord-015922-5wwy0m2k 85 26 prevent prevent VB cord-015922-5wwy0m2k 85 27 mucositis mucositis NNP cord-015922-5wwy0m2k 85 28 [ [ -LRB- cord-015922-5wwy0m2k 85 29 24 24 CD cord-015922-5wwy0m2k 85 30 ] ] -RRB- cord-015922-5wwy0m2k 85 31 in in IN cord-015922-5wwy0m2k 85 32 patients patient NNS cord-015922-5wwy0m2k 85 33 undergoing undergo VBG cord-015922-5wwy0m2k 85 34 myeloablative myeloablative JJ cord-015922-5wwy0m2k 85 35 conditioning conditioning NN cord-015922-5wwy0m2k 85 36 . . . cord-015922-5wwy0m2k 86 1 After after IN cord-015922-5wwy0m2k 86 2 engraftment engraftment NN cord-015922-5wwy0m2k 86 3 , , , cord-015922-5wwy0m2k 86 4 the the DT cord-015922-5wwy0m2k 86 5 risk risk NN cord-015922-5wwy0m2k 86 6 of of IN cord-015922-5wwy0m2k 86 7 bacterial bacterial JJ cord-015922-5wwy0m2k 86 8 infections infection NNS cord-015922-5wwy0m2k 86 9 depend depend VBP cord-015922-5wwy0m2k 86 10 on on IN cord-015922-5wwy0m2k 86 11 the the DT cord-015922-5wwy0m2k 86 12 community community NN cord-015922-5wwy0m2k 86 13 exposures exposure NNS cord-015922-5wwy0m2k 86 14 to to IN cord-015922-5wwy0m2k 86 15 common common JJ cord-015922-5wwy0m2k 86 16 and and CC cord-015922-5wwy0m2k 86 17 opportunistic opportunistic JJ cord-015922-5wwy0m2k 86 18 bacteria bacteria NNS cord-015922-5wwy0m2k 86 19 ( ( -LRB- cord-015922-5wwy0m2k 86 20 e.g. e.g. RB cord-015922-5wwy0m2k 86 21 , , , cord-015922-5wwy0m2k 86 22 Nocardia Nocardia NNP cord-015922-5wwy0m2k 86 23 , , , cord-015922-5wwy0m2k 86 24 Rhodococcus Rhodococcus NNP cord-015922-5wwy0m2k 86 25 , , , cord-015922-5wwy0m2k 86 26 Listeria Listeria NNP cord-015922-5wwy0m2k 86 27 ) ) -RRB- cord-015922-5wwy0m2k 86 28 , , , cord-015922-5wwy0m2k 86 29 the the DT cord-015922-5wwy0m2k 86 30 presence presence NN cord-015922-5wwy0m2k 86 31 of of IN cord-015922-5wwy0m2k 86 32 acute acute JJ cord-015922-5wwy0m2k 86 33 and and CC cord-015922-5wwy0m2k 86 34 chronic chronic JJ cord-015922-5wwy0m2k 86 35 GVHD GVHD NNP cord-015922-5wwy0m2k 86 36 , , , cord-015922-5wwy0m2k 86 37 the the DT cord-015922-5wwy0m2k 86 38 degree degree NN cord-015922-5wwy0m2k 86 39 of of IN cord-015922-5wwy0m2k 86 40 B b NN cord-015922-5wwy0m2k 86 41 - - HYPH cord-015922-5wwy0m2k 86 42 cell cell NN cord-015922-5wwy0m2k 86 43 reconstitution reconstitution NN cord-015922-5wwy0m2k 86 44 and and CC cord-015922-5wwy0m2k 86 45 the the DT cord-015922-5wwy0m2k 86 46 use use NN cord-015922-5wwy0m2k 86 47 of of IN cord-015922-5wwy0m2k 86 48 trimethoprim trimethoprim NNP cord-015922-5wwy0m2k 86 49 - - HYPH cord-015922-5wwy0m2k 86 50 sulfamethoxazole sulfamethoxazole NNP cord-015922-5wwy0m2k 86 51 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 86 52 . . . cord-015922-5wwy0m2k 87 1 Patients patient NNS cord-015922-5wwy0m2k 87 2 with with IN cord-015922-5wwy0m2k 87 3 chronic chronic JJ cord-015922-5wwy0m2k 87 4 GVHD GVHD NNP cord-015922-5wwy0m2k 87 5 are be VBP cord-015922-5wwy0m2k 87 6 at at IN cord-015922-5wwy0m2k 87 7 risk risk NN cord-015922-5wwy0m2k 87 8 for for IN cord-015922-5wwy0m2k 87 9 invasive invasive JJ cord-015922-5wwy0m2k 87 10 infection infection NN cord-015922-5wwy0m2k 87 11 from from IN cord-015922-5wwy0m2k 87 12 encapsulated encapsulate VBN cord-015922-5wwy0m2k 87 13 organisms organism NNS cord-015922-5wwy0m2k 87 14 , , , cord-015922-5wwy0m2k 87 15 particularly particularly RB cord-015922-5wwy0m2k 87 16 Streptococcus streptococcus NN cord-015922-5wwy0m2k 87 17 pneumoniae pneumoniae NN cord-015922-5wwy0m2k 87 18 , , , cord-015922-5wwy0m2k 87 19 Haemophilus haemophilus JJ cord-015922-5wwy0m2k 87 20 influenzae influenzae NN cord-015922-5wwy0m2k 87 21 and and CC cord-015922-5wwy0m2k 87 22 Neisseria Neisseria NNP cord-015922-5wwy0m2k 87 23 meningitidis meningitidis NN cord-015922-5wwy0m2k 87 24 . . . cord-015922-5wwy0m2k 88 1 It -PRON- PRP cord-015922-5wwy0m2k 88 2 is be VBZ cord-015922-5wwy0m2k 88 3 postulated postulate VBN cord-015922-5wwy0m2k 88 4 that that IN cord-015922-5wwy0m2k 88 5 the the DT cord-015922-5wwy0m2k 88 6 combination combination NN cord-015922-5wwy0m2k 88 7 of of IN cord-015922-5wwy0m2k 88 8 B b NN cord-015922-5wwy0m2k 88 9 lymphocyte lymphocyte NN cord-015922-5wwy0m2k 88 10 dysfunction dysfunction NN cord-015922-5wwy0m2k 88 11 secondary secondary JJ cord-015922-5wwy0m2k 88 12 to to IN cord-015922-5wwy0m2k 88 13 the the DT cord-015922-5wwy0m2k 88 14 conditioning conditioning NN cord-015922-5wwy0m2k 88 15 regimen regimen NN cord-015922-5wwy0m2k 88 16 and and CC cord-015922-5wwy0m2k 88 17 the the DT cord-015922-5wwy0m2k 88 18 effects effect NNS cord-015922-5wwy0m2k 88 19 of of IN cord-015922-5wwy0m2k 88 20 GVHD GVHD NNP cord-015922-5wwy0m2k 88 21 and and CC cord-015922-5wwy0m2k 88 22 its -PRON- PRP$ cord-015922-5wwy0m2k 88 23 treatment treatment NN cord-015922-5wwy0m2k 88 24 have have VBP cord-015922-5wwy0m2k 88 25 resulted result VBN cord-015922-5wwy0m2k 88 26 in in IN cord-015922-5wwy0m2k 88 27 the the DT cord-015922-5wwy0m2k 88 28 loss loss NN cord-015922-5wwy0m2k 88 29 and and CC cord-015922-5wwy0m2k 88 30 failure failure NN cord-015922-5wwy0m2k 88 31 to to TO cord-015922-5wwy0m2k 88 32 develop develop VB cord-015922-5wwy0m2k 88 33 an an DT cord-015922-5wwy0m2k 88 34 opsonizing opsonize VBG cord-015922-5wwy0m2k 88 35 antibody antibody NN cord-015922-5wwy0m2k 88 36 to to IN cord-015922-5wwy0m2k 88 37 these these DT cord-015922-5wwy0m2k 88 38 organisms organism NNS cord-015922-5wwy0m2k 88 39 , , , cord-015922-5wwy0m2k 88 40 particularly particularly RB cord-015922-5wwy0m2k 88 41 Streptococcus streptococcus NN cord-015922-5wwy0m2k 88 42 pneumoniae pneumoniae NN cord-015922-5wwy0m2k 88 43 . . . cord-015922-5wwy0m2k 89 1 In in IN cord-015922-5wwy0m2k 89 2 addition addition NN cord-015922-5wwy0m2k 89 3 , , , cord-015922-5wwy0m2k 89 4 for for IN cord-015922-5wwy0m2k 89 5 at at RB cord-015922-5wwy0m2k 89 6 least least RBS cord-015922-5wwy0m2k 89 7 one one CD cord-015922-5wwy0m2k 89 8 to to TO cord-015922-5wwy0m2k 89 9 two two CD cord-015922-5wwy0m2k 89 10 years year NNS cord-015922-5wwy0m2k 89 11 post post NN cord-015922-5wwy0m2k 89 12 - - NN cord-015922-5wwy0m2k 89 13 transplant transplant NN cord-015922-5wwy0m2k 89 14 , , , cord-015922-5wwy0m2k 89 15 HSCT HSCT NNP cord-015922-5wwy0m2k 89 16 patients patient NNS cord-015922-5wwy0m2k 89 17 have have VBP cord-015922-5wwy0m2k 89 18 an an DT cord-015922-5wwy0m2k 89 19 inadequate inadequate JJ cord-015922-5wwy0m2k 89 20 response response NN cord-015922-5wwy0m2k 89 21 to to IN cord-015922-5wwy0m2k 89 22 pneumococcal pneumococcal JJ cord-015922-5wwy0m2k 89 23 vaccine vaccine NN cord-015922-5wwy0m2k 89 24 . . . cord-015922-5wwy0m2k 90 1 As as IN cord-015922-5wwy0m2k 90 2 IgG igg NN cord-015922-5wwy0m2k 90 3 levels level NNS cord-015922-5wwy0m2k 90 4 are be VBP cord-015922-5wwy0m2k 90 5 often often RB cord-015922-5wwy0m2k 90 6 low low JJ cord-015922-5wwy0m2k 90 7 for for IN cord-015922-5wwy0m2k 90 8 some some DT cord-015922-5wwy0m2k 90 9 time time NN cord-015922-5wwy0m2k 90 10 after after IN cord-015922-5wwy0m2k 90 11 HSCT HSCT NNP cord-015922-5wwy0m2k 90 12 , , , cord-015922-5wwy0m2k 90 13 they -PRON- PRP cord-015922-5wwy0m2k 90 14 should should MD cord-015922-5wwy0m2k 90 15 be be VB cord-015922-5wwy0m2k 90 16 routinely routinely RB cord-015922-5wwy0m2k 90 17 monitored monitor VBN cord-015922-5wwy0m2k 90 18 , , , cord-015922-5wwy0m2k 90 19 with with IN cord-015922-5wwy0m2k 90 20 replacement replacement NN cord-015922-5wwy0m2k 90 21 being be VBG cord-015922-5wwy0m2k 90 22 considered consider VBN cord-015922-5wwy0m2k 90 23 when when WRB cord-015922-5wwy0m2k 90 24 the the DT cord-015922-5wwy0m2k 90 25 IgG igg NN cord-015922-5wwy0m2k 90 26 level level NN cord-015922-5wwy0m2k 90 27 falls fall VBZ cord-015922-5wwy0m2k 90 28 below below IN cord-015922-5wwy0m2k 90 29 500 500 CD cord-015922-5wwy0m2k 90 30 mg mg NNP cord-015922-5wwy0m2k 90 31 / / SYM cord-015922-5wwy0m2k 90 32 ml ml NNP cord-015922-5wwy0m2k 90 33 [ [ -LRB- cord-015922-5wwy0m2k 90 34 25 25 CD cord-015922-5wwy0m2k 90 35 , , , cord-015922-5wwy0m2k 90 36 26 26 CD cord-015922-5wwy0m2k 90 37 ] ] -RRB- cord-015922-5wwy0m2k 90 38 . . . cord-015922-5wwy0m2k 91 1 In in IN cord-015922-5wwy0m2k 91 2 addition addition NN cord-015922-5wwy0m2k 91 3 , , , cord-015922-5wwy0m2k 91 4 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 91 5 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 91 6 , , , cord-015922-5wwy0m2k 91 7 such such JJ cord-015922-5wwy0m2k 91 8 as as IN cord-015922-5wwy0m2k 91 9 with with IN cord-015922-5wwy0m2k 91 10 low low JJ cord-015922-5wwy0m2k 91 11 - - HYPH cord-015922-5wwy0m2k 91 12 dose dose NN cord-015922-5wwy0m2k 91 13 trimethoprimsulfamethoxazole trimethoprimsulfamethoxazole NN cord-015922-5wwy0m2k 91 14 ( ( -LRB- cord-015922-5wwy0m2k 91 15 one one CD cord-015922-5wwy0m2k 91 16 single single JJ cord-015922-5wwy0m2k 91 17 strength strength NN cord-015922-5wwy0m2k 91 18 tablet tablet NN cord-015922-5wwy0m2k 91 19 daily daily RB cord-015922-5wwy0m2k 91 20 for for IN cord-015922-5wwy0m2k 91 21 PCP PCP NNP cord-015922-5wwy0m2k 91 22 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 91 23 ) ) -RRB- cord-015922-5wwy0m2k 91 24 , , , cord-015922-5wwy0m2k 91 25 may may MD cord-015922-5wwy0m2k 91 26 afford afford VB cord-015922-5wwy0m2k 91 27 further further JJ cord-015922-5wwy0m2k 91 28 protection protection NN cord-015922-5wwy0m2k 91 29 against against IN cord-015922-5wwy0m2k 91 30 this this DT cord-015922-5wwy0m2k 91 31 problem problem NN cord-015922-5wwy0m2k 91 32 [ [ -LRB- cord-015922-5wwy0m2k 91 33 1 1 CD cord-015922-5wwy0m2k 91 34 , , , cord-015922-5wwy0m2k 91 35 3 3 CD cord-015922-5wwy0m2k 91 36 ] ] -RRB- cord-015922-5wwy0m2k 91 37 . . . cord-015922-5wwy0m2k 92 1 There there EX cord-015922-5wwy0m2k 92 2 are be VBP cord-015922-5wwy0m2k 92 3 several several JJ cord-015922-5wwy0m2k 92 4 classes class NNS cord-015922-5wwy0m2k 92 5 of of IN cord-015922-5wwy0m2k 92 6 viral viral JJ cord-015922-5wwy0m2k 92 7 infection infection NN cord-015922-5wwy0m2k 92 8 of of IN cord-015922-5wwy0m2k 92 9 particular particular JJ cord-015922-5wwy0m2k 92 10 importance importance NN cord-015922-5wwy0m2k 92 11 in in IN cord-015922-5wwy0m2k 92 12 the the DT cord-015922-5wwy0m2k 92 13 HSCT HSCT NNP cord-015922-5wwy0m2k 92 14 recipient recipient NN cord-015922-5wwy0m2k 92 15 : : : cord-015922-5wwy0m2k 92 16 those those DT cord-015922-5wwy0m2k 92 17 due due JJ cord-015922-5wwy0m2k 92 18 to to IN cord-015922-5wwy0m2k 92 19 herpesviruses herpesviruses NNP cord-015922-5wwy0m2k 92 20 ( ( -LRB- cord-015922-5wwy0m2k 92 21 CMV CMV NNP cord-015922-5wwy0m2k 92 22 , , , cord-015922-5wwy0m2k 92 23 EBV EBV NNP cord-015922-5wwy0m2k 92 24 , , , cord-015922-5wwy0m2k 92 25 HSV HSV NNP cord-015922-5wwy0m2k 92 26 , , , cord-015922-5wwy0m2k 92 27 VZV VZV NNP cord-015922-5wwy0m2k 92 28 and and CC cord-015922-5wwy0m2k 92 29 human human JJ cord-015922-5wwy0m2k 92 30 herpesvirus-6 herpesvirus-6 NNP cord-015922-5wwy0m2k 92 31 [ [ -LRB- cord-015922-5wwy0m2k 92 32 HHV-6 HHV-6 NNP cord-015922-5wwy0m2k 92 33 ] ] -RRB- cord-015922-5wwy0m2k 92 34 ) ) -RRB- cord-015922-5wwy0m2k 92 35 ; ; : cord-015922-5wwy0m2k 92 36 those those DT cord-015922-5wwy0m2k 92 37 due due JJ cord-015922-5wwy0m2k 92 38 to to IN cord-015922-5wwy0m2k 92 39 hepatitis hepatitis NN cord-015922-5wwy0m2k 92 40 viruses virus NNS cord-015922-5wwy0m2k 92 41 ( ( -LRB- cord-015922-5wwy0m2k 92 42 e.g. e.g. RB cord-015922-5wwy0m2k 92 43 , , , cord-015922-5wwy0m2k 92 44 hepatitis hepatitis NN cord-015922-5wwy0m2k 92 45 B B NNP cord-015922-5wwy0m2k 92 46 [ [ -LRB- cord-015922-5wwy0m2k 92 47 HBV HBV NNP cord-015922-5wwy0m2k 92 48 ] ] -RRB- cord-015922-5wwy0m2k 92 49 ) ) -RRB- cord-015922-5wwy0m2k 92 50 ; ; : cord-015922-5wwy0m2k 92 51 those those DT cord-015922-5wwy0m2k 92 52 due due JJ cord-015922-5wwy0m2k 92 53 to to IN cord-015922-5wwy0m2k 92 54 respiratory respiratory JJ cord-015922-5wwy0m2k 92 55 viruses virus NNS cord-015922-5wwy0m2k 92 56 ( ( -LRB- cord-015922-5wwy0m2k 92 57 e.g. e.g. RB cord-015922-5wwy0m2k 92 58 , , , cord-015922-5wwy0m2k 92 59 influenza influenza NN cord-015922-5wwy0m2k 92 60 , , , cord-015922-5wwy0m2k 92 61 RSV RSV NNP cord-015922-5wwy0m2k 92 62 , , , cord-015922-5wwy0m2k 92 63 parainfluenza parainfluenza NNP cord-015922-5wwy0m2k 92 64 , , , cord-015922-5wwy0m2k 92 65 adenoviruses adenovirus NNS cord-015922-5wwy0m2k 92 66 , , , cord-015922-5wwy0m2k 92 67 and and CC cord-015922-5wwy0m2k 92 68 others other NNS cord-015922-5wwy0m2k 92 69 ) ) -RRB- cord-015922-5wwy0m2k 92 70 , , , cord-015922-5wwy0m2k 92 71 and and CC cord-015922-5wwy0m2k 92 72 those those DT cord-015922-5wwy0m2k 92 73 due due JJ cord-015922-5wwy0m2k 92 74 to to IN cord-015922-5wwy0m2k 92 75 polyoma polyoma NN cord-015922-5wwy0m2k 92 76 viruses virus NNS cord-015922-5wwy0m2k 92 77 . . . cord-015922-5wwy0m2k 93 1 The the DT cord-015922-5wwy0m2k 93 2 human human JJ cord-015922-5wwy0m2k 93 3 herpesviruses herpesviruse NNS cord-015922-5wwy0m2k 93 4 share share VBP cord-015922-5wwy0m2k 93 5 a a DT cord-015922-5wwy0m2k 93 6 number number NN cord-015922-5wwy0m2k 93 7 of of IN cord-015922-5wwy0m2k 93 8 characteristics characteristic NNS cord-015922-5wwy0m2k 93 9 that that WDT cord-015922-5wwy0m2k 93 10 make make VBP cord-015922-5wwy0m2k 93 11 them -PRON- PRP cord-015922-5wwy0m2k 93 12 particularly particularly RB cord-015922-5wwy0m2k 93 13 successful successful JJ cord-015922-5wwy0m2k 93 14 pathogens pathogen NNS cord-015922-5wwy0m2k 93 15 in in IN cord-015922-5wwy0m2k 93 16 HSCT HSCT NNP cord-015922-5wwy0m2k 93 17 recipients recipient NNS cord-015922-5wwy0m2k 93 18 [ [ -LRB- cord-015922-5wwy0m2k 93 19 1 1 CD cord-015922-5wwy0m2k 93 20 , , , cord-015922-5wwy0m2k 93 21 4 4 CD cord-015922-5wwy0m2k 93 22 , , , cord-015922-5wwy0m2k 93 23 27 27 CD cord-015922-5wwy0m2k 93 24 ] ] -RRB- cord-015922-5wwy0m2k 93 25 : : : cord-015922-5wwy0m2k 94 1 1 1 LS cord-015922-5wwy0m2k 94 2 . . . cord-015922-5wwy0m2k 95 1 Latency Latency NNP cord-015922-5wwy0m2k 96 1 Once once IN cord-015922-5wwy0m2k 96 2 infected infect VBN cord-015922-5wwy0m2k 96 3 with with IN cord-015922-5wwy0m2k 96 4 a a DT cord-015922-5wwy0m2k 96 5 herpesvirus herpesvirus NN cord-015922-5wwy0m2k 96 6 , , , cord-015922-5wwy0m2k 96 7 one one CD cord-015922-5wwy0m2k 96 8 is be VBZ cord-015922-5wwy0m2k 96 9 infected infect VBN cord-015922-5wwy0m2k 96 10 for for IN cord-015922-5wwy0m2k 96 11 life life NN cord-015922-5wwy0m2k 96 12 , , , cord-015922-5wwy0m2k 96 13 with with IN cord-015922-5wwy0m2k 96 14 a a DT cord-015922-5wwy0m2k 96 15 circulating circulate VBG cord-015922-5wwy0m2k 96 16 antibody antibody NN cord-015922-5wwy0m2k 96 17 ( ( -LRB- cord-015922-5wwy0m2k 96 18 seropositivity seropositivity NN cord-015922-5wwy0m2k 96 19 ) ) -RRB- cord-015922-5wwy0m2k 96 20 in in IN cord-015922-5wwy0m2k 96 21 the the DT cord-015922-5wwy0m2k 96 22 absence absence NN cord-015922-5wwy0m2k 96 23 of of IN cord-015922-5wwy0m2k 96 24 active active JJ cord-015922-5wwy0m2k 96 25 viral viral JJ cord-015922-5wwy0m2k 96 26 replication replication NN cord-015922-5wwy0m2k 96 27 being be VBG cord-015922-5wwy0m2k 96 28 the the DT cord-015922-5wwy0m2k 96 29 classic classic JJ cord-015922-5wwy0m2k 96 30 marker marker NN cord-015922-5wwy0m2k 96 31 for for IN cord-015922-5wwy0m2k 96 32 latent latent JJ cord-015922-5wwy0m2k 96 33 infection infection NN cord-015922-5wwy0m2k 96 34 . . . cord-015922-5wwy0m2k 97 1 Reactivation reactivation NN cord-015922-5wwy0m2k 97 2 from from IN cord-015922-5wwy0m2k 97 3 latency latency NN cord-015922-5wwy0m2k 97 4 may may MD cord-015922-5wwy0m2k 97 5 be be VB cord-015922-5wwy0m2k 97 6 triggered trigger VBN cord-015922-5wwy0m2k 97 7 by by IN cord-015922-5wwy0m2k 97 8 tumor tumor NN cord-015922-5wwy0m2k 97 9 necrosis necrosis NN cord-015922-5wwy0m2k 97 10 factor factor NN cord-015922-5wwy0m2k 97 11 ( ( -LRB- cord-015922-5wwy0m2k 97 12 TNF TNF NNP cord-015922-5wwy0m2k 97 13 ) ) -RRB- cord-015922-5wwy0m2k 97 14 , , , cord-015922-5wwy0m2k 97 15 with with IN cord-015922-5wwy0m2k 97 16 the the DT cord-015922-5wwy0m2k 97 17 catecholamines catecholamine NNS cord-015922-5wwy0m2k 97 18 epinephrine epinephrine NN cord-015922-5wwy0m2k 97 19 and and CC cord-015922-5wwy0m2k 97 20 norepinephrine norepinephrine NN cord-015922-5wwy0m2k 97 21 and and CC cord-015922-5wwy0m2k 97 22 proinflammatory proinflammatory JJ cord-015922-5wwy0m2k 97 23 prostaglandins prostaglandin NNS cord-015922-5wwy0m2k 97 24 also also RB cord-015922-5wwy0m2k 97 25 playing play VBG cord-015922-5wwy0m2k 97 26 a a DT cord-015922-5wwy0m2k 97 27 role role NN cord-015922-5wwy0m2k 97 28 . . . cord-015922-5wwy0m2k 98 1 Thus thus RB cord-015922-5wwy0m2k 98 2 , , , cord-015922-5wwy0m2k 98 3 the the DT cord-015922-5wwy0m2k 98 4 virus virus NN cord-015922-5wwy0m2k 98 5 may may MD cord-015922-5wwy0m2k 98 6 be be VB cord-015922-5wwy0m2k 98 7 reactivated reactivate VBN cord-015922-5wwy0m2k 98 8 by by IN cord-015922-5wwy0m2k 98 9 such such JJ cord-015922-5wwy0m2k 98 10 processes process NNS cord-015922-5wwy0m2k 98 11 as as IN cord-015922-5wwy0m2k 98 12 sepsis sepsis NN cord-015922-5wwy0m2k 98 13 , , , cord-015922-5wwy0m2k 98 14 GVHD GVHD NNP cord-015922-5wwy0m2k 98 15 , , , cord-015922-5wwy0m2k 98 16 allogeneic allogeneic NN cord-015922-5wwy0m2k 98 17 reactions reaction NNS cord-015922-5wwy0m2k 98 18 , , , cord-015922-5wwy0m2k 98 19 OKT3 OKT3 NNP cord-015922-5wwy0m2k 98 20 and and CC cord-015922-5wwy0m2k 98 21 antilymphocyte antilymphocyte NNP cord-015922-5wwy0m2k 98 22 globulin globulin NNP cord-015922-5wwy0m2k 98 23 . . . cord-015922-5wwy0m2k 99 1 Once once IN cord-015922-5wwy0m2k 99 2 a a DT cord-015922-5wwy0m2k 99 3 replicating replicate VBG cord-015922-5wwy0m2k 99 4 virus virus NN cord-015922-5wwy0m2k 99 5 is be VBZ cord-015922-5wwy0m2k 99 6 present present JJ cord-015922-5wwy0m2k 99 7 , , , cord-015922-5wwy0m2k 99 8 medications medication NNS cord-015922-5wwy0m2k 99 9 such such JJ cord-015922-5wwy0m2k 99 10 as as IN cord-015922-5wwy0m2k 99 11 cyclosporine cyclosporine NN cord-015922-5wwy0m2k 99 12 , , , cord-015922-5wwy0m2k 99 13 tacrolimus tacrolimus NN cord-015922-5wwy0m2k 99 14 and and CC cord-015922-5wwy0m2k 99 15 prednisone prednisone NNP cord-015922-5wwy0m2k 99 16 may may MD cord-015922-5wwy0m2k 99 17 significantly significantly RB cord-015922-5wwy0m2k 99 18 amplify amplify VB cord-015922-5wwy0m2k 99 19 the the DT cord-015922-5wwy0m2k 99 20 viral viral JJ cord-015922-5wwy0m2k 99 21 replication replication NN cord-015922-5wwy0m2k 99 22 . . . cord-015922-5wwy0m2k 100 1 2 2 LS cord-015922-5wwy0m2k 100 2 . . . cord-015922-5wwy0m2k 101 1 Cell Cell NNP cord-015922-5wwy0m2k 101 2 Association Association NNP cord-015922-5wwy0m2k 102 1 These these DT cord-015922-5wwy0m2k 102 2 viruses virus NNS cord-015922-5wwy0m2k 102 3 are be VBP cord-015922-5wwy0m2k 102 4 highly highly RB cord-015922-5wwy0m2k 102 5 cell cell NN cord-015922-5wwy0m2k 102 6 - - HYPH cord-015922-5wwy0m2k 102 7 associated associate VBN cord-015922-5wwy0m2k 102 8 , , , cord-015922-5wwy0m2k 102 9 meaning mean VBG cord-015922-5wwy0m2k 102 10 that that IN cord-015922-5wwy0m2k 102 11 transmission transmission NN cord-015922-5wwy0m2k 102 12 occurs occur VBZ cord-015922-5wwy0m2k 102 13 through through IN cord-015922-5wwy0m2k 102 14 intimate intimate JJ cord-015922-5wwy0m2k 102 15 person person NN cord-015922-5wwy0m2k 102 16 - - HYPH cord-015922-5wwy0m2k 102 17 to to IN cord-015922-5wwy0m2k 102 18 - - HYPH cord-015922-5wwy0m2k 102 19 person person NN cord-015922-5wwy0m2k 102 20 contact contact NN cord-015922-5wwy0m2k 102 21 , , , cord-015922-5wwy0m2k 102 22 or or CC cord-015922-5wwy0m2k 102 23 transfusion transfusion NN cord-015922-5wwy0m2k 102 24 or or CC cord-015922-5wwy0m2k 102 25 transplantation transplantation NN cord-015922-5wwy0m2k 102 26 of of IN cord-015922-5wwy0m2k 102 27 latently latently RB cord-015922-5wwy0m2k 102 28 or or CC cord-015922-5wwy0m2k 102 29 actively actively RB cord-015922-5wwy0m2k 102 30 replicating replicate VBG cord-015922-5wwy0m2k 102 31 cells cell NNS cord-015922-5wwy0m2k 102 32 from from IN cord-015922-5wwy0m2k 102 33 a a DT cord-015922-5wwy0m2k 102 34 seropositive seropositive JJ cord-015922-5wwy0m2k 102 35 donor donor NN cord-015922-5wwy0m2k 102 36 . . . cord-015922-5wwy0m2k 103 1 Humoral humoral JJ cord-015922-5wwy0m2k 103 2 immunity immunity NN cord-015922-5wwy0m2k 103 3 is be VBZ cord-015922-5wwy0m2k 103 4 , , , cord-015922-5wwy0m2k 103 5 hence hence RB cord-015922-5wwy0m2k 103 6 , , , cord-015922-5wwy0m2k 103 7 less less RBR cord-015922-5wwy0m2k 103 8 important important JJ cord-015922-5wwy0m2k 103 9 than than IN cord-015922-5wwy0m2k 103 10 cell cell NN cord-015922-5wwy0m2k 103 11 - - HYPH cord-015922-5wwy0m2k 103 12 mediated mediate VBN cord-015922-5wwy0m2k 103 13 immunity immunity NN cord-015922-5wwy0m2k 103 14 . . . cord-015922-5wwy0m2k 104 1 Indeed indeed RB cord-015922-5wwy0m2k 104 2 , , , cord-015922-5wwy0m2k 104 3 the the DT cord-015922-5wwy0m2k 104 4 key key JJ cord-015922-5wwy0m2k 104 5 host host NN cord-015922-5wwy0m2k 104 6 defense defense NN cord-015922-5wwy0m2k 104 7 is be VBZ cord-015922-5wwy0m2k 104 8 accomplished accomplish VBN cord-015922-5wwy0m2k 104 9 by by IN cord-015922-5wwy0m2k 104 10 major major JJ cord-015922-5wwy0m2k 104 11 histocompatibility histocompatibility NN cord-015922-5wwy0m2k 104 12 complex complex NN cord-015922-5wwy0m2k 104 13 ( ( -LRB- cord-015922-5wwy0m2k 104 14 MHC)-restricted mhc)-restricte VBN cord-015922-5wwy0m2k 104 15 , , , cord-015922-5wwy0m2k 104 16 virus virus NN cord-015922-5wwy0m2k 104 17 - - HYPH cord-015922-5wwy0m2k 104 18 specific specific JJ cord-015922-5wwy0m2k 104 19 , , , cord-015922-5wwy0m2k 104 20 cytotoxic cytotoxic JJ cord-015922-5wwy0m2k 104 21 T t NN cord-015922-5wwy0m2k 104 22 cells cell NNS cord-015922-5wwy0m2k 104 23 , , , cord-015922-5wwy0m2k 104 24 just just RB cord-015922-5wwy0m2k 104 25 that that DT cord-015922-5wwy0m2k 104 26 component component NN cord-015922-5wwy0m2k 104 27 of of IN cord-015922-5wwy0m2k 104 28 host host NN cord-015922-5wwy0m2k 104 29 defense defense NN cord-015922-5wwy0m2k 104 30 most most RBS cord-015922-5wwy0m2k 104 31 affected affect VBN cord-015922-5wwy0m2k 104 32 by by IN cord-015922-5wwy0m2k 104 33 GVHD GVHD NNP cord-015922-5wwy0m2k 104 34 and and CC cord-015922-5wwy0m2k 104 35 its -PRON- PRP$ cord-015922-5wwy0m2k 104 36 treatment treatment NN cord-015922-5wwy0m2k 104 37 . . . cord-015922-5wwy0m2k 105 1 3 3 LS cord-015922-5wwy0m2k 105 2 . . . cord-015922-5wwy0m2k 106 1 Oncogenesis Oncogenesis NNP cord-015922-5wwy0m2k 106 2 Herpesviruses Herpesviruses NNP cord-015922-5wwy0m2k 106 3 , , , cord-015922-5wwy0m2k 106 4 such such JJ cord-015922-5wwy0m2k 106 5 as as IN cord-015922-5wwy0m2k 106 6 EBV EBV NNP cord-015922-5wwy0m2k 106 7 and and CC cord-015922-5wwy0m2k 106 8 HHV-8 HHV-8 NNP cord-015922-5wwy0m2k 106 9 , , , cord-015922-5wwy0m2k 106 10 play play VB cord-015922-5wwy0m2k 106 11 a a DT cord-015922-5wwy0m2k 106 12 direct direct JJ cord-015922-5wwy0m2k 106 13 role role NN cord-015922-5wwy0m2k 106 14 in in IN cord-015922-5wwy0m2k 106 15 oncogenesis oncogenesis NN cord-015922-5wwy0m2k 106 16 - - HYPH cord-015922-5wwy0m2k 106 17 causing cause VBG cord-015922-5wwy0m2k 106 18 post post JJ cord-015922-5wwy0m2k 106 19 - - JJ cord-015922-5wwy0m2k 106 20 transplant transplant JJ cord-015922-5wwy0m2k 106 21 lymphoproliferative lymphoproliferative JJ cord-015922-5wwy0m2k 106 22 disease disease NN cord-015922-5wwy0m2k 106 23 ( ( -LRB- cord-015922-5wwy0m2k 106 24 PTLD PTLD NNP cord-015922-5wwy0m2k 106 25 ) ) -RRB- cord-015922-5wwy0m2k 106 26 and and CC cord-015922-5wwy0m2k 106 27 Kaposi Kaposi NNP cord-015922-5wwy0m2k 106 28 's 's POS cord-015922-5wwy0m2k 106 29 sarcoma sarcoma NN cord-015922-5wwy0m2k 106 30 , , , cord-015922-5wwy0m2k 106 31 respectively respectively RB cord-015922-5wwy0m2k 106 32 . . . cord-015922-5wwy0m2k 107 1 Herpesviruses Herpesviruses NNP cord-015922-5wwy0m2k 107 2 may may MD cord-015922-5wwy0m2k 107 3 also also RB cord-015922-5wwy0m2k 107 4 play play VB cord-015922-5wwy0m2k 107 5 an an DT cord-015922-5wwy0m2k 107 6 indirect indirect JJ cord-015922-5wwy0m2k 107 7 role role NN cord-015922-5wwy0m2k 107 8 in in IN cord-015922-5wwy0m2k 107 9 oncogenesis oncogenesis NN cord-015922-5wwy0m2k 107 10 with with IN cord-015922-5wwy0m2k 107 11 symptomatic symptomatic JJ cord-015922-5wwy0m2k 107 12 CMV CMV NNP cord-015922-5wwy0m2k 107 13 disease disease NN cord-015922-5wwy0m2k 107 14 , , , cord-015922-5wwy0m2k 107 15 increasing increase VBG cord-015922-5wwy0m2k 107 16 the the DT cord-015922-5wwy0m2k 107 17 incidence incidence NN cord-015922-5wwy0m2k 107 18 of of IN cord-015922-5wwy0m2k 107 19 EBV EBV NNP cord-015922-5wwy0m2k 107 20 - - HYPH cord-015922-5wwy0m2k 107 21 associated associate VBN cord-015922-5wwy0m2k 107 22 PTLD PTLD NNP cord-015922-5wwy0m2k 107 23 severalfold severalfold RB cord-015922-5wwy0m2k 107 24 . . . cord-015922-5wwy0m2k 108 1 4 4 LS cord-015922-5wwy0m2k 108 2 . . . cord-015922-5wwy0m2k 109 1 Indirect indirect JJ cord-015922-5wwy0m2k 109 2 Effects effect NNS cord-015922-5wwy0m2k 110 1 In in IN cord-015922-5wwy0m2k 110 2 addition addition NN cord-015922-5wwy0m2k 110 3 to to IN cord-015922-5wwy0m2k 110 4 the the DT cord-015922-5wwy0m2k 110 5 direct direct JJ cord-015922-5wwy0m2k 110 6 causation causation NN cord-015922-5wwy0m2k 110 7 of of IN cord-015922-5wwy0m2k 110 8 infectious infectious JJ cord-015922-5wwy0m2k 110 9 disease disease NN cord-015922-5wwy0m2k 110 10 syndromes syndrome NNS cord-015922-5wwy0m2k 110 11 , , , cord-015922-5wwy0m2k 110 12 human human JJ cord-015922-5wwy0m2k 110 13 herpesviruses herpesviruse NNS cord-015922-5wwy0m2k 110 14 , , , cord-015922-5wwy0m2k 110 15 particularly particularly RB cord-015922-5wwy0m2k 110 16 CMV CMV NNP cord-015922-5wwy0m2k 110 17 , , , cord-015922-5wwy0m2k 110 18 have have VBP cord-015922-5wwy0m2k 110 19 indirect indirect JJ cord-015922-5wwy0m2k 110 20 effects effect NNS cord-015922-5wwy0m2k 110 21 that that WDT cord-015922-5wwy0m2k 110 22 are be VBP cord-015922-5wwy0m2k 110 23 clinically clinically RB cord-015922-5wwy0m2k 110 24 important important JJ cord-015922-5wwy0m2k 110 25 . . . cord-015922-5wwy0m2k 111 1 It -PRON- PRP cord-015922-5wwy0m2k 111 2 is be VBZ cord-015922-5wwy0m2k 111 3 believed believe VBN cord-015922-5wwy0m2k 111 4 that that IN cord-015922-5wwy0m2k 111 5 cytokines cytokine NNS cord-015922-5wwy0m2k 111 6 , , , cord-015922-5wwy0m2k 111 7 chemokines chemokine NNS cord-015922-5wwy0m2k 111 8 and and CC cord-015922-5wwy0m2k 111 9 growth growth NN cord-015922-5wwy0m2k 111 10 factors factor NNS cord-015922-5wwy0m2k 111 11 produced produce VBN cord-015922-5wwy0m2k 111 12 in in IN cord-015922-5wwy0m2k 111 13 response response NN cord-015922-5wwy0m2k 111 14 to to IN cord-015922-5wwy0m2k 111 15 viral viral JJ cord-015922-5wwy0m2k 111 16 replication replication NN cord-015922-5wwy0m2k 111 17 may may MD cord-015922-5wwy0m2k 111 18 be be VB cord-015922-5wwy0m2k 111 19 responsible responsible JJ cord-015922-5wwy0m2k 111 20 for for IN cord-015922-5wwy0m2k 111 21 these these DT cord-015922-5wwy0m2k 111 22 effects effect NNS cord-015922-5wwy0m2k 111 23 . . . cord-015922-5wwy0m2k 112 1 They -PRON- PRP cord-015922-5wwy0m2k 112 2 include include VBP cord-015922-5wwy0m2k 112 3 , , , cord-015922-5wwy0m2k 112 4 in in IN cord-015922-5wwy0m2k 112 5 addition addition NN cord-015922-5wwy0m2k 112 6 to to IN cord-015922-5wwy0m2k 112 7 the the DT cord-015922-5wwy0m2k 112 8 modulation modulation NN cord-015922-5wwy0m2k 112 9 of of IN cord-015922-5wwy0m2k 112 10 oncogenesis oncogenesis NN cord-015922-5wwy0m2k 112 11 , , , cord-015922-5wwy0m2k 112 12 increasing increase VBG cord-015922-5wwy0m2k 112 13 the the DT cord-015922-5wwy0m2k 112 14 net net JJ cord-015922-5wwy0m2k 112 15 state state NN cord-015922-5wwy0m2k 112 16 of of IN cord-015922-5wwy0m2k 112 17 immunosuppression immunosuppression NN cord-015922-5wwy0m2k 112 18 so so IN cord-015922-5wwy0m2k 112 19 that that IN cord-015922-5wwy0m2k 112 20 the the DT cord-015922-5wwy0m2k 112 21 risk risk NN cord-015922-5wwy0m2k 112 22 of of IN cord-015922-5wwy0m2k 112 23 opportunistic opportunistic JJ cord-015922-5wwy0m2k 112 24 infection infection NN cord-015922-5wwy0m2k 112 25 is be VBZ cord-015922-5wwy0m2k 112 26 increased increase VBN cord-015922-5wwy0m2k 112 27 . . . cord-015922-5wwy0m2k 113 1 This this DT cord-015922-5wwy0m2k 113 2 last last JJ cord-015922-5wwy0m2k 113 3 point point NN cord-015922-5wwy0m2k 113 4 is be VBZ cord-015922-5wwy0m2k 113 5 particularly particularly RB cord-015922-5wwy0m2k 113 6 important important JJ cord-015922-5wwy0m2k 113 7 , , , cord-015922-5wwy0m2k 113 8 as as IN cord-015922-5wwy0m2k 113 9 a a DT cord-015922-5wwy0m2k 113 10 variety variety NN cord-015922-5wwy0m2k 113 11 of of IN cord-015922-5wwy0m2k 113 12 experiments experiment NNS cord-015922-5wwy0m2k 113 13 have have VBP cord-015922-5wwy0m2k 113 14 shown show VBN cord-015922-5wwy0m2k 113 15 that that IN cord-015922-5wwy0m2k 113 16 GVHD GVHD NNP cord-015922-5wwy0m2k 113 17 and and CC cord-015922-5wwy0m2k 113 18 infection infection NN cord-015922-5wwy0m2k 113 19 are be VBP cord-015922-5wwy0m2k 113 20 closely closely RB cord-015922-5wwy0m2k 113 21 linked link VBN cord-015922-5wwy0m2k 113 22 by by IN cord-015922-5wwy0m2k 113 23 the the DT cord-015922-5wwy0m2k 113 24 production production NN cord-015922-5wwy0m2k 113 25 of of IN cord-015922-5wwy0m2k 113 26 these these DT cord-015922-5wwy0m2k 113 27 mediators mediator NNS cord-015922-5wwy0m2k 113 28 . . . cord-015922-5wwy0m2k 114 1 That that RB cord-015922-5wwy0m2k 114 2 is is RB cord-015922-5wwy0m2k 114 3 , , , cord-015922-5wwy0m2k 114 4 there there EX cord-015922-5wwy0m2k 114 5 is be VBZ cord-015922-5wwy0m2k 114 6 a a DT cord-015922-5wwy0m2k 114 7 bidirectional bidirectional JJ cord-015922-5wwy0m2k 114 8 trafficking trafficking NN cord-015922-5wwy0m2k 114 9 of of IN cord-015922-5wwy0m2k 114 10 mediators mediator NNS cord-015922-5wwy0m2k 114 11 between between IN cord-015922-5wwy0m2k 114 12 these these DT cord-015922-5wwy0m2k 114 13 two two CD cord-015922-5wwy0m2k 114 14 processes process NNS cord-015922-5wwy0m2k 114 15 . . . cord-015922-5wwy0m2k 115 1 The the DT cord-015922-5wwy0m2k 115 2 clinically clinically RB cord-015922-5wwy0m2k 115 3 most most RBS cord-015922-5wwy0m2k 115 4 important important JJ cord-015922-5wwy0m2k 115 5 direct direct JJ cord-015922-5wwy0m2k 115 6 effects effect NNS cord-015922-5wwy0m2k 115 7 of of IN cord-015922-5wwy0m2k 115 8 CMV CMV NNP cord-015922-5wwy0m2k 115 9 in in IN cord-015922-5wwy0m2k 115 10 the the DT cord-015922-5wwy0m2k 115 11 HSCT HSCT NNP cord-015922-5wwy0m2k 115 12 recipient recipient NN cord-015922-5wwy0m2k 115 13 are be VBP cord-015922-5wwy0m2k 115 14 pneumonia pneumonia NN cord-015922-5wwy0m2k 115 15 and and CC cord-015922-5wwy0m2k 115 16 gastrointestinal gastrointestinal JJ cord-015922-5wwy0m2k 115 17 disease disease NN cord-015922-5wwy0m2k 115 18 . . . cord-015922-5wwy0m2k 116 1 Before before IN cord-015922-5wwy0m2k 116 2 effective effective JJ cord-015922-5wwy0m2k 116 3 antiviral antiviral JJ cord-015922-5wwy0m2k 116 4 treatment treatment NN cord-015922-5wwy0m2k 116 5 became become VBD cord-015922-5wwy0m2k 116 6 available available JJ cord-015922-5wwy0m2k 116 7 , , , cord-015922-5wwy0m2k 116 8 CMV CMV NNP cord-015922-5wwy0m2k 116 9 pneumonia pneumonia NN cord-015922-5wwy0m2k 116 10 occurred occur VBD cord-015922-5wwy0m2k 116 11 in in IN cord-015922-5wwy0m2k 116 12 20 20 CD cord-015922-5wwy0m2k 116 13 to to TO cord-015922-5wwy0m2k 116 14 30 30 CD cord-015922-5wwy0m2k 116 15 percent percent NN cord-015922-5wwy0m2k 116 16 of of IN cord-015922-5wwy0m2k 116 17 seropositive seropositive JJ cord-015922-5wwy0m2k 116 18 recipients recipient NNS cord-015922-5wwy0m2k 116 19 and and CC cord-015922-5wwy0m2k 116 20 had have VBD cord-015922-5wwy0m2k 116 21 an an DT cord-015922-5wwy0m2k 116 22 associated associate VBN cord-015922-5wwy0m2k 116 23 mortality mortality NN cord-015922-5wwy0m2k 116 24 around around IN cord-015922-5wwy0m2k 116 25 80 80 CD cord-015922-5wwy0m2k 116 26 percent percent NN cord-015922-5wwy0m2k 116 27 [ [ -LRB- cord-015922-5wwy0m2k 116 28 28 28 CD cord-015922-5wwy0m2k 116 29 ] ] -RRB- cord-015922-5wwy0m2k 116 30 . . . cord-015922-5wwy0m2k 117 1 CMV CMV NNP cord-015922-5wwy0m2k 117 2 commonly commonly RB cord-015922-5wwy0m2k 117 3 causes cause VBZ cord-015922-5wwy0m2k 117 4 fever fever NN cord-015922-5wwy0m2k 117 5 in in IN cord-015922-5wwy0m2k 117 6 the the DT cord-015922-5wwy0m2k 117 7 absence absence NN cord-015922-5wwy0m2k 117 8 of of IN cord-015922-5wwy0m2k 117 9 preemptive preemptive JJ cord-015922-5wwy0m2k 117 10 treatment treatment NN cord-015922-5wwy0m2k 117 11 , , , cord-015922-5wwy0m2k 117 12 and and CC cord-015922-5wwy0m2k 117 13 end end NN cord-015922-5wwy0m2k 117 14 - - HYPH cord-015922-5wwy0m2k 117 15 organ organ NN cord-015922-5wwy0m2k 117 16 disease disease NN cord-015922-5wwy0m2k 117 17 ( ( -LRB- cord-015922-5wwy0m2k 117 18 hepatitis hepatitis NN cord-015922-5wwy0m2k 117 19 , , , cord-015922-5wwy0m2k 117 20 bone bone NN cord-015922-5wwy0m2k 117 21 marrow marrow NN cord-015922-5wwy0m2k 117 22 dysfunction dysfunction NN cord-015922-5wwy0m2k 117 23 , , , cord-015922-5wwy0m2k 117 24 retinitis retinitis NN cord-015922-5wwy0m2k 117 25 , , , cord-015922-5wwy0m2k 117 26 and and CC cord-015922-5wwy0m2k 117 27 encephalitis encephalitis NN cord-015922-5wwy0m2k 117 28 ) ) -RRB- cord-015922-5wwy0m2k 117 29 may may MD cord-015922-5wwy0m2k 117 30 occur occur VB cord-015922-5wwy0m2k 117 31 . . . cord-015922-5wwy0m2k 118 1 Among among IN cord-015922-5wwy0m2k 118 2 allogeneic allogeneic JJ cord-015922-5wwy0m2k 118 3 HSCT HSCT NNP cord-015922-5wwy0m2k 118 4 recipients recipient NNS cord-015922-5wwy0m2k 118 5 , , , cord-015922-5wwy0m2k 118 6 the the DT cord-015922-5wwy0m2k 118 7 risk risk NN cord-015922-5wwy0m2k 118 8 of of IN cord-015922-5wwy0m2k 118 9 CMV CMV NNP cord-015922-5wwy0m2k 118 10 reactivation reactivation NN cord-015922-5wwy0m2k 118 11 ( ( -LRB- cord-015922-5wwy0m2k 118 12 60 60 CD cord-015922-5wwy0m2k 118 13 - - SYM cord-015922-5wwy0m2k 118 14 80 80 CD cord-015922-5wwy0m2k 118 15 % % NN cord-015922-5wwy0m2k 118 16 ) ) -RRB- cord-015922-5wwy0m2k 118 17 and and CC cord-015922-5wwy0m2k 118 18 end end NN cord-015922-5wwy0m2k 118 19 - - HYPH cord-015922-5wwy0m2k 118 20 organ organ NN cord-015922-5wwy0m2k 118 21 disease disease NN cord-015922-5wwy0m2k 118 22 is be VBZ cord-015922-5wwy0m2k 118 23 greatest great JJS cord-015922-5wwy0m2k 118 24 in in IN cord-015922-5wwy0m2k 118 25 the the DT cord-015922-5wwy0m2k 118 26 seropositive seropositive JJ cord-015922-5wwy0m2k 118 27 recipient recipient NN cord-015922-5wwy0m2k 118 28 who who WP cord-015922-5wwy0m2k 118 29 receives receive VBZ cord-015922-5wwy0m2k 118 30 a a DT cord-015922-5wwy0m2k 118 31 graft graft NN cord-015922-5wwy0m2k 118 32 from from IN cord-015922-5wwy0m2k 118 33 a a DT cord-015922-5wwy0m2k 118 34 CMV CMV NNP cord-015922-5wwy0m2k 118 35 seronegative seronegative JJ cord-015922-5wwy0m2k 118 36 donor donor NN cord-015922-5wwy0m2k 118 37 ( ( -LRB- cord-015922-5wwy0m2k 118 38 CMV CMV NNP cord-015922-5wwy0m2k 118 39 D−/R+ D−/R+ NNP cord-015922-5wwy0m2k 118 40 ) ) -RRB- cord-015922-5wwy0m2k 118 41 , , , cord-015922-5wwy0m2k 118 42 likely likely RB cord-015922-5wwy0m2k 118 43 due due IN cord-015922-5wwy0m2k 118 44 to to IN cord-015922-5wwy0m2k 118 45 the the DT cord-015922-5wwy0m2k 118 46 loss loss NN cord-015922-5wwy0m2k 118 47 of of IN cord-015922-5wwy0m2k 118 48 native native JJ cord-015922-5wwy0m2k 118 49 immunity immunity NN cord-015922-5wwy0m2k 118 50 during during IN cord-015922-5wwy0m2k 118 51 the the DT cord-015922-5wwy0m2k 118 52 transplant transplant NN cord-015922-5wwy0m2k 118 53 process process NN cord-015922-5wwy0m2k 118 54 and and CC cord-015922-5wwy0m2k 118 55 immune immune JJ cord-015922-5wwy0m2k 118 56 reconstitution reconstitution NN cord-015922-5wwy0m2k 118 57 with with IN cord-015922-5wwy0m2k 118 58 a a DT cord-015922-5wwy0m2k 118 59 CMV CMV NNP cord-015922-5wwy0m2k 118 60 naïve naïve JJ cord-015922-5wwy0m2k 118 61 allograft allograft NN cord-015922-5wwy0m2k 118 62 [ [ -LRB- cord-015922-5wwy0m2k 118 63 29 29 CD cord-015922-5wwy0m2k 118 64 , , , cord-015922-5wwy0m2k 118 65 30 30 CD cord-015922-5wwy0m2k 118 66 ] ] -RRB- cord-015922-5wwy0m2k 118 67 . . . cord-015922-5wwy0m2k 119 1 Patients patient NNS cord-015922-5wwy0m2k 119 2 who who WP cord-015922-5wwy0m2k 119 3 are be VBP cord-015922-5wwy0m2k 119 4 CMV CMV NNP cord-015922-5wwy0m2k 119 5 D+/R+ D+/R+ NNP cord-015922-5wwy0m2k 119 6 have have VBP cord-015922-5wwy0m2k 119 7 CMV CMV NNP cord-015922-5wwy0m2k 119 8 reactivation reactivation NN cord-015922-5wwy0m2k 119 9 ( ( -LRB- cord-015922-5wwy0m2k 119 10 50 50 CD cord-015922-5wwy0m2k 119 11 - - SYM cord-015922-5wwy0m2k 119 12 60 60 CD cord-015922-5wwy0m2k 119 13 % % NN cord-015922-5wwy0m2k 119 14 ) ) -RRB- cord-015922-5wwy0m2k 119 15 and and CC cord-015922-5wwy0m2k 119 16 disease disease NN cord-015922-5wwy0m2k 119 17 risk risk NN cord-015922-5wwy0m2k 119 18 that that WDT cord-015922-5wwy0m2k 119 19 is be VBZ cord-015922-5wwy0m2k 119 20 similar similar JJ cord-015922-5wwy0m2k 119 21 to to IN cord-015922-5wwy0m2k 119 22 or or CC cord-015922-5wwy0m2k 119 23 slightly slightly RB cord-015922-5wwy0m2k 119 24 lower low JJR cord-015922-5wwy0m2k 119 25 than than IN cord-015922-5wwy0m2k 119 26 that that DT cord-015922-5wwy0m2k 119 27 of of IN cord-015922-5wwy0m2k 119 28 the the DT cord-015922-5wwy0m2k 119 29 CMV CMV NNP cord-015922-5wwy0m2k 119 30 D−/R+ D−/R+ NNP cord-015922-5wwy0m2k 119 31 patient patient NN cord-015922-5wwy0m2k 119 32 . . . cord-015922-5wwy0m2k 120 1 Patients patient NNS cord-015922-5wwy0m2k 120 2 who who WP cord-015922-5wwy0m2k 120 3 are be VBP cord-015922-5wwy0m2k 120 4 CMV CMV NNP cord-015922-5wwy0m2k 120 5 D+/ D+/ NNP cord-015922-5wwy0m2k 120 6 R− R− NNP cord-015922-5wwy0m2k 120 7 have have VBP cord-015922-5wwy0m2k 120 8 a a DT cord-015922-5wwy0m2k 120 9 lower low JJR cord-015922-5wwy0m2k 120 10 risk risk NN cord-015922-5wwy0m2k 120 11 of of IN cord-015922-5wwy0m2k 120 12 CMV CMV NNP cord-015922-5wwy0m2k 120 13 infection infection NN cord-015922-5wwy0m2k 120 14 ( ( -LRB- cord-015922-5wwy0m2k 120 15 10 10 CD cord-015922-5wwy0m2k 120 16 - - SYM cord-015922-5wwy0m2k 120 17 30 30 CD cord-015922-5wwy0m2k 120 18 % % NN cord-015922-5wwy0m2k 120 19 ) ) -RRB- cord-015922-5wwy0m2k 120 20 and and CC cord-015922-5wwy0m2k 120 21 disease disease NN cord-015922-5wwy0m2k 120 22 , , , cord-015922-5wwy0m2k 120 23 but but CC cord-015922-5wwy0m2k 120 24 higher high JJR cord-015922-5wwy0m2k 120 25 than than IN cord-015922-5wwy0m2k 120 26 CMV CMV NNP cord-015922-5wwy0m2k 120 27 D−/R− D−/R− NNP cord-015922-5wwy0m2k 120 28 patients patient NNS cord-015922-5wwy0m2k 120 29 ( ( -LRB- cord-015922-5wwy0m2k 120 30 < < XX cord-015922-5wwy0m2k 120 31 5 5 CD cord-015922-5wwy0m2k 120 32 % % NN cord-015922-5wwy0m2k 120 33 ) ) -RRB- cord-015922-5wwy0m2k 120 34 . . . cord-015922-5wwy0m2k 121 1 The the DT cord-015922-5wwy0m2k 121 2 risk risk NN cord-015922-5wwy0m2k 121 3 of of IN cord-015922-5wwy0m2k 121 4 CMV CMV NNP cord-015922-5wwy0m2k 121 5 infection infection NN cord-015922-5wwy0m2k 121 6 in in IN cord-015922-5wwy0m2k 121 7 this this DT cord-015922-5wwy0m2k 121 8 latter latter JJ cord-015922-5wwy0m2k 121 9 group group NN cord-015922-5wwy0m2k 121 10 has have VBZ cord-015922-5wwy0m2k 121 11 been be VBN cord-015922-5wwy0m2k 121 12 greatly greatly RB cord-015922-5wwy0m2k 121 13 decreased decrease VBN cord-015922-5wwy0m2k 121 14 by by IN cord-015922-5wwy0m2k 121 15 use use NN cord-015922-5wwy0m2k 121 16 of of IN cord-015922-5wwy0m2k 121 17 leukoreduced leukoreduced JJ cord-015922-5wwy0m2k 121 18 blood blood NN cord-015922-5wwy0m2k 121 19 products product NNS cord-015922-5wwy0m2k 121 20 or or CC cord-015922-5wwy0m2k 121 21 by by IN cord-015922-5wwy0m2k 121 22 exclusive exclusive JJ cord-015922-5wwy0m2k 121 23 use use NN cord-015922-5wwy0m2k 121 24 of of IN cord-015922-5wwy0m2k 121 25 CMV CMV NNP cord-015922-5wwy0m2k 121 26 negative negative JJ cord-015922-5wwy0m2k 121 27 products product NNS cord-015922-5wwy0m2k 121 28 when when WRB cord-015922-5wwy0m2k 121 29 available available JJ cord-015922-5wwy0m2k 121 30 [ [ -LRB- cord-015922-5wwy0m2k 121 31 31 31 CD cord-015922-5wwy0m2k 121 32 ] ] -RRB- cord-015922-5wwy0m2k 121 33 . . . cord-015922-5wwy0m2k 122 1 The the DT cord-015922-5wwy0m2k 122 2 risks risk NNS cord-015922-5wwy0m2k 122 3 of of IN cord-015922-5wwy0m2k 122 4 CMV CMV NNP cord-015922-5wwy0m2k 122 5 reactivation reactivation NN cord-015922-5wwy0m2k 122 6 and and CC cord-015922-5wwy0m2k 122 7 disease disease NN cord-015922-5wwy0m2k 122 8 among among IN cord-015922-5wwy0m2k 122 9 autologous autologous JJ cord-015922-5wwy0m2k 122 10 HSCT HSCT NNP cord-015922-5wwy0m2k 122 11 recipients recipient NNS cord-015922-5wwy0m2k 122 12 is be VBZ cord-015922-5wwy0m2k 122 13 minimal minimal JJ cord-015922-5wwy0m2k 122 14 ( ( -LRB- cord-015922-5wwy0m2k 122 15 < < NNP cord-015922-5wwy0m2k 122 16 1 1 CD cord-015922-5wwy0m2k 122 17 % % NN cord-015922-5wwy0m2k 122 18 ) ) -RRB- cord-015922-5wwy0m2k 122 19 [ [ -LRB- cord-015922-5wwy0m2k 122 20 1 1 CD cord-015922-5wwy0m2k 122 21 , , , cord-015922-5wwy0m2k 122 22 4 4 CD cord-015922-5wwy0m2k 122 23 ] ] -RRB- cord-015922-5wwy0m2k 122 24 . . . cord-015922-5wwy0m2k 123 1 Another another DT cord-015922-5wwy0m2k 123 2 major major JJ cord-015922-5wwy0m2k 123 3 risk risk NN cord-015922-5wwy0m2k 123 4 factor factor NN cord-015922-5wwy0m2k 123 5 for for IN cord-015922-5wwy0m2k 123 6 the the DT cord-015922-5wwy0m2k 123 7 development development NN cord-015922-5wwy0m2k 123 8 of of IN cord-015922-5wwy0m2k 123 9 CMV CMV NNP cord-015922-5wwy0m2k 123 10 reactivation reactivation NN cord-015922-5wwy0m2k 123 11 and and CC cord-015922-5wwy0m2k 123 12 disease disease NN cord-015922-5wwy0m2k 123 13 is be VBZ cord-015922-5wwy0m2k 123 14 the the DT cord-015922-5wwy0m2k 123 15 occurrence occurrence NN cord-015922-5wwy0m2k 123 16 , , , cord-015922-5wwy0m2k 123 17 severity severity NN cord-015922-5wwy0m2k 123 18 and and CC cord-015922-5wwy0m2k 123 19 treatment treatment NN cord-015922-5wwy0m2k 123 20 of of IN cord-015922-5wwy0m2k 123 21 acute acute JJ cord-015922-5wwy0m2k 123 22 GVHD GVHD NNP cord-015922-5wwy0m2k 123 23 [ [ -LRB- cord-015922-5wwy0m2k 123 24 29 29 CD cord-015922-5wwy0m2k 123 25 , , , cord-015922-5wwy0m2k 123 26 30 30 CD cord-015922-5wwy0m2k 123 27 ] ] -RRB- cord-015922-5wwy0m2k 123 28 . . . cord-015922-5wwy0m2k 124 1 Other other JJ cord-015922-5wwy0m2k 124 2 potential potential JJ cord-015922-5wwy0m2k 124 3 factors factor NNS cord-015922-5wwy0m2k 124 4 associated associate VBN cord-015922-5wwy0m2k 124 5 with with IN cord-015922-5wwy0m2k 124 6 an an DT cord-015922-5wwy0m2k 124 7 increased increase VBN cord-015922-5wwy0m2k 124 8 risk risk NN cord-015922-5wwy0m2k 124 9 of of IN cord-015922-5wwy0m2k 124 10 CMV CMV NNP cord-015922-5wwy0m2k 124 11 reactivation reactivation NN cord-015922-5wwy0m2k 124 12 and and CC cord-015922-5wwy0m2k 124 13 disease disease NN cord-015922-5wwy0m2k 124 14 are be VBP cord-015922-5wwy0m2k 124 15 reception reception NN cord-015922-5wwy0m2k 124 16 of of IN cord-015922-5wwy0m2k 124 17 T T NNP cord-015922-5wwy0m2k 124 18 cell cell NN cord-015922-5wwy0m2k 124 19 - - HYPH cord-015922-5wwy0m2k 124 20 depleted deplete VBN cord-015922-5wwy0m2k 124 21 or or CC cord-015922-5wwy0m2k 124 22 cord cord NN cord-015922-5wwy0m2k 124 23 blood blood NN cord-015922-5wwy0m2k 124 24 allograft allograft NN cord-015922-5wwy0m2k 124 25 , , , cord-015922-5wwy0m2k 124 26 whether whether IN cord-015922-5wwy0m2k 124 27 the the DT cord-015922-5wwy0m2k 124 28 donor donor NN cord-015922-5wwy0m2k 124 29 is be VBZ cord-015922-5wwy0m2k 124 30 unrelated unrelated JJ cord-015922-5wwy0m2k 124 31 or or CC cord-015922-5wwy0m2k 124 32 mismatched mismatched JJ cord-015922-5wwy0m2k 124 33 , , , cord-015922-5wwy0m2k 124 34 or or CC cord-015922-5wwy0m2k 124 35 donated donate VBN cord-015922-5wwy0m2k 124 36 bone bone NN cord-015922-5wwy0m2k 124 37 marrow marrow NN cord-015922-5wwy0m2k 124 38 ( ( -LRB- cord-015922-5wwy0m2k 124 39 instead instead RB cord-015922-5wwy0m2k 124 40 of of IN cord-015922-5wwy0m2k 124 41 peripheral peripheral JJ cord-015922-5wwy0m2k 124 42 stem stem NN cord-015922-5wwy0m2k 124 43 cells cell NNS cord-015922-5wwy0m2k 124 44 ) ) -RRB- cord-015922-5wwy0m2k 124 45 , , , cord-015922-5wwy0m2k 124 46 and and CC cord-015922-5wwy0m2k 124 47 whether whether IN cord-015922-5wwy0m2k 124 48 the the DT cord-015922-5wwy0m2k 124 49 conditioning conditioning NN cord-015922-5wwy0m2k 124 50 regimen regimen NN cord-015922-5wwy0m2k 124 51 was be VBD cord-015922-5wwy0m2k 124 52 myeloablative myeloablative NNP cord-015922-5wwy0m2k 124 53 [ [ -LRB- cord-015922-5wwy0m2k 124 54 29 29 CD cord-015922-5wwy0m2k 124 55 , , , cord-015922-5wwy0m2k 124 56 32 32 CD cord-015922-5wwy0m2k 124 57 ] ] -RRB- cord-015922-5wwy0m2k 124 58 . . . cord-015922-5wwy0m2k 125 1 The the DT cord-015922-5wwy0m2k 125 2 most most RBS cord-015922-5wwy0m2k 125 3 widely widely RB cord-015922-5wwy0m2k 125 4 used use VBN cord-015922-5wwy0m2k 125 5 therapy therapy NN cord-015922-5wwy0m2k 125 6 for for IN cord-015922-5wwy0m2k 125 7 clinical clinical JJ cord-015922-5wwy0m2k 125 8 CMV CMV NNP cord-015922-5wwy0m2k 125 9 disease disease NN cord-015922-5wwy0m2k 125 10 is be VBZ cord-015922-5wwy0m2k 125 11 ganciclovir ganciclovir NNP cord-015922-5wwy0m2k 125 12 , , , cord-015922-5wwy0m2k 125 13 which which WDT cord-015922-5wwy0m2k 125 14 can can MD cord-015922-5wwy0m2k 125 15 be be VB cord-015922-5wwy0m2k 125 16 administered administer VBN cord-015922-5wwy0m2k 125 17 either either CC cord-015922-5wwy0m2k 125 18 intravenously intravenously RB cord-015922-5wwy0m2k 125 19 or or CC cord-015922-5wwy0m2k 125 20 orally orally RB cord-015922-5wwy0m2k 125 21 in in IN cord-015922-5wwy0m2k 125 22 the the DT cord-015922-5wwy0m2k 125 23 form form NN cord-015922-5wwy0m2k 125 24 of of IN cord-015922-5wwy0m2k 125 25 a a DT cord-015922-5wwy0m2k 125 26 prodrug prodrug NN cord-015922-5wwy0m2k 125 27 , , , cord-015922-5wwy0m2k 125 28 valganciclovir valganciclovir NNP cord-015922-5wwy0m2k 125 29 , , , cord-015922-5wwy0m2k 125 30 with with IN cord-015922-5wwy0m2k 125 31 an an DT cord-015922-5wwy0m2k 125 32 acceptable acceptable JJ cord-015922-5wwy0m2k 125 33 bioavailability bioavailability NN cord-015922-5wwy0m2k 125 34 profile profile NN cord-015922-5wwy0m2k 125 35 ( ( -LRB- cord-015922-5wwy0m2k 125 36 ~50 ~50 NFP cord-015922-5wwy0m2k 125 37 - - SYM cord-015922-5wwy0m2k 125 38 60 60 CD cord-015922-5wwy0m2k 125 39 % % NN cord-015922-5wwy0m2k 125 40 ) ) -RRB- cord-015922-5wwy0m2k 125 41 . . . cord-015922-5wwy0m2k 126 1 Typically typically RB cord-015922-5wwy0m2k 126 2 , , , cord-015922-5wwy0m2k 126 3 the the DT cord-015922-5wwy0m2k 126 4 parenteral parenteral JJ cord-015922-5wwy0m2k 126 5 form form NN cord-015922-5wwy0m2k 126 6 is be VBZ cord-015922-5wwy0m2k 126 7 administered administer VBN cord-015922-5wwy0m2k 126 8 until until IN cord-015922-5wwy0m2k 126 9 the the DT cord-015922-5wwy0m2k 126 10 patient patient NN cord-015922-5wwy0m2k 126 11 is be VBZ cord-015922-5wwy0m2k 126 12 able able JJ cord-015922-5wwy0m2k 126 13 to to TO cord-015922-5wwy0m2k 126 14 tolerate tolerate VB cord-015922-5wwy0m2k 126 15 oral oral JJ cord-015922-5wwy0m2k 126 16 therapy therapy NN cord-015922-5wwy0m2k 126 17 . . . cord-015922-5wwy0m2k 127 1 Gastrointestinal gastrointestinal JJ cord-015922-5wwy0m2k 127 2 absorption absorption NN cord-015922-5wwy0m2k 127 3 of of IN cord-015922-5wwy0m2k 127 4 valganciclovir valganciclovir NNS cord-015922-5wwy0m2k 127 5 , , , cord-015922-5wwy0m2k 127 6 even even RB cord-015922-5wwy0m2k 127 7 in in IN cord-015922-5wwy0m2k 127 8 the the DT cord-015922-5wwy0m2k 127 9 setting setting NN cord-015922-5wwy0m2k 127 10 of of IN cord-015922-5wwy0m2k 127 11 mild mild JJ cord-015922-5wwy0m2k 127 12 to to TO cord-015922-5wwy0m2k 127 13 moderate moderate JJ cord-015922-5wwy0m2k 127 14 GI GI NNP cord-015922-5wwy0m2k 127 15 GVHD GVHD NNP cord-015922-5wwy0m2k 127 16 , , , cord-015922-5wwy0m2k 127 17 has have VBZ cord-015922-5wwy0m2k 127 18 been be VBN cord-015922-5wwy0m2k 127 19 demonstrated demonstrate VBN cord-015922-5wwy0m2k 127 20 to to TO cord-015922-5wwy0m2k 127 21 be be VB cord-015922-5wwy0m2k 127 22 adequate adequate JJ cord-015922-5wwy0m2k 127 23 [ [ -LRB- cord-015922-5wwy0m2k 127 24 33 33 CD cord-015922-5wwy0m2k 127 25 , , , cord-015922-5wwy0m2k 127 26 34 34 CD cord-015922-5wwy0m2k 127 27 ] ] -RRB- cord-015922-5wwy0m2k 127 28 . . . cord-015922-5wwy0m2k 128 1 Duration duration NN cord-015922-5wwy0m2k 128 2 of of IN cord-015922-5wwy0m2k 128 3 treatment treatment NN cord-015922-5wwy0m2k 128 4 depends depend VBZ cord-015922-5wwy0m2k 128 5 on on IN cord-015922-5wwy0m2k 128 6 the the DT cord-015922-5wwy0m2k 128 7 clinical clinical JJ cord-015922-5wwy0m2k 128 8 response response NN cord-015922-5wwy0m2k 128 9 and and CC cord-015922-5wwy0m2k 128 10 the the DT cord-015922-5wwy0m2k 128 11 nature nature NN cord-015922-5wwy0m2k 128 12 of of IN cord-015922-5wwy0m2k 128 13 the the DT cord-015922-5wwy0m2k 128 14 recovery recovery NN cord-015922-5wwy0m2k 128 15 of of IN cord-015922-5wwy0m2k 128 16 native native JJ cord-015922-5wwy0m2k 128 17 immune immune JJ cord-015922-5wwy0m2k 128 18 function function NN cord-015922-5wwy0m2k 128 19 . . . cord-015922-5wwy0m2k 129 1 In in IN cord-015922-5wwy0m2k 129 2 the the DT cord-015922-5wwy0m2k 129 3 case case NN cord-015922-5wwy0m2k 129 4 of of IN cord-015922-5wwy0m2k 129 5 serious serious JJ cord-015922-5wwy0m2k 129 6 illness illness NN cord-015922-5wwy0m2k 129 7 , , , cord-015922-5wwy0m2k 129 8 particularly particularly RB cord-015922-5wwy0m2k 129 9 pneumonia pneumonia NN cord-015922-5wwy0m2k 129 10 , , , cord-015922-5wwy0m2k 129 11 anti anti JJ cord-015922-5wwy0m2k 129 12 - - JJ cord-015922-5wwy0m2k 129 13 CMV cmv JJ cord-015922-5wwy0m2k 129 14 hyperimmune hyperimmune NN cord-015922-5wwy0m2k 129 15 globulin globulin NN cord-015922-5wwy0m2k 129 16 can can MD cord-015922-5wwy0m2k 129 17 be be VB cord-015922-5wwy0m2k 129 18 considered consider VBN cord-015922-5wwy0m2k 129 19 as as IN cord-015922-5wwy0m2k 129 20 adjunctive adjunctive JJ cord-015922-5wwy0m2k 129 21 therapy therapy NN cord-015922-5wwy0m2k 129 22 . . . cord-015922-5wwy0m2k 130 1 Despite despite IN cord-015922-5wwy0m2k 130 2 these these DT cord-015922-5wwy0m2k 130 3 efforts effort NNS cord-015922-5wwy0m2k 130 4 , , , cord-015922-5wwy0m2k 130 5 the the DT cord-015922-5wwy0m2k 130 6 mortality mortality NN cord-015922-5wwy0m2k 130 7 from from IN cord-015922-5wwy0m2k 130 8 CMV CMV NNP cord-015922-5wwy0m2k 130 9 pneumonia pneumonia NN cord-015922-5wwy0m2k 130 10 remains remain VBZ cord-015922-5wwy0m2k 130 11 high high JJ cord-015922-5wwy0m2k 130 12 . . . cord-015922-5wwy0m2k 131 1 The the DT cord-015922-5wwy0m2k 131 2 major major JJ cord-015922-5wwy0m2k 131 3 toxicity toxicity NN cord-015922-5wwy0m2k 131 4 of of IN cord-015922-5wwy0m2k 131 5 ganciclovir ganciclovir NNP cord-015922-5wwy0m2k 131 6 is be VBZ cord-015922-5wwy0m2k 131 7 myelosuppression myelosuppression NNP cord-015922-5wwy0m2k 131 8 , , , cord-015922-5wwy0m2k 131 9 so so IN cord-015922-5wwy0m2k 131 10 that that DT cord-015922-5wwy0m2k 131 11 great great JJ cord-015922-5wwy0m2k 131 12 effort effort NN cord-015922-5wwy0m2k 131 13 is be VBZ cord-015922-5wwy0m2k 131 14 placed place VBN cord-015922-5wwy0m2k 131 15 in in IN cord-015922-5wwy0m2k 131 16 monitoring monitor VBG cord-015922-5wwy0m2k 131 17 these these DT cord-015922-5wwy0m2k 131 18 patients patient NNS cord-015922-5wwy0m2k 131 19 closely closely RB cord-015922-5wwy0m2k 131 20 and and CC cord-015922-5wwy0m2k 131 21 adjusting adjust VBG cord-015922-5wwy0m2k 131 22 doses dose NNS cord-015922-5wwy0m2k 131 23 appropriately appropriately RB cord-015922-5wwy0m2k 131 24 [ [ -LRB- cord-015922-5wwy0m2k 131 25 1 1 CD cord-015922-5wwy0m2k 131 26 , , , cord-015922-5wwy0m2k 131 27 4 4 CD cord-015922-5wwy0m2k 131 28 ] ] -RRB- cord-015922-5wwy0m2k 131 29 . . . cord-015922-5wwy0m2k 132 1 Occasionally occasionally RB cord-015922-5wwy0m2k 132 2 , , , cord-015922-5wwy0m2k 132 3 G G NNP cord-015922-5wwy0m2k 132 4 - - HYPH cord-015922-5wwy0m2k 132 5 CSF CSF NNP cord-015922-5wwy0m2k 132 6 support support NN cord-015922-5wwy0m2k 132 7 may may MD cord-015922-5wwy0m2k 132 8 be be VB cord-015922-5wwy0m2k 132 9 required require VBN cord-015922-5wwy0m2k 132 10 to to TO cord-015922-5wwy0m2k 132 11 preserve preserve VB cord-015922-5wwy0m2k 132 12 an an DT cord-015922-5wwy0m2k 132 13 acceptable acceptable JJ cord-015922-5wwy0m2k 132 14 neutrophil neutrophil NN cord-015922-5wwy0m2k 132 15 count count NN cord-015922-5wwy0m2k 132 16 and and CC cord-015922-5wwy0m2k 132 17 to to TO cord-015922-5wwy0m2k 132 18 allow allow VB cord-015922-5wwy0m2k 132 19 adequate adequate JJ cord-015922-5wwy0m2k 132 20 therapy therapy NN cord-015922-5wwy0m2k 132 21 of of IN cord-015922-5wwy0m2k 132 22 a a DT cord-015922-5wwy0m2k 132 23 serious serious JJ cord-015922-5wwy0m2k 132 24 CMV CMV NNP cord-015922-5wwy0m2k 132 25 infection infection NN cord-015922-5wwy0m2k 132 26 . . . cord-015922-5wwy0m2k 133 1 While while IN cord-015922-5wwy0m2k 133 2 certain certain JJ cord-015922-5wwy0m2k 133 3 medications medication NNS cord-015922-5wwy0m2k 133 4 , , , cord-015922-5wwy0m2k 133 5 such such JJ cord-015922-5wwy0m2k 133 6 as as IN cord-015922-5wwy0m2k 133 7 ATG ATG NNP cord-015922-5wwy0m2k 133 8 and and CC cord-015922-5wwy0m2k 133 9 OKT3 OKT3 NNP cord-015922-5wwy0m2k 133 10 , , , cord-015922-5wwy0m2k 133 11 are be VBP cord-015922-5wwy0m2k 133 12 likely likely JJ cord-015922-5wwy0m2k 133 13 to to TO cord-015922-5wwy0m2k 133 14 induce induce VB cord-015922-5wwy0m2k 133 15 CMV CMV NNP cord-015922-5wwy0m2k 133 16 reactivation reactivation NN cord-015922-5wwy0m2k 133 17 , , , cord-015922-5wwy0m2k 133 18 others other NNS cord-015922-5wwy0m2k 133 19 like like IN cord-015922-5wwy0m2k 133 20 sirolimus sirolimus NNP cord-015922-5wwy0m2k 133 21 may may MD cord-015922-5wwy0m2k 133 22 inhibit inhibit VB cord-015922-5wwy0m2k 133 23 this this DT cord-015922-5wwy0m2k 133 24 [ [ -LRB- cord-015922-5wwy0m2k 133 25 29 29 CD cord-015922-5wwy0m2k 133 26 ] ] -RRB- cord-015922-5wwy0m2k 133 27 . . . cord-015922-5wwy0m2k 134 1 Current current JJ cord-015922-5wwy0m2k 134 2 strategies strategy NNS cord-015922-5wwy0m2k 134 3 are be VBP cord-015922-5wwy0m2k 134 4 based base VBN cord-015922-5wwy0m2k 134 5 on on IN cord-015922-5wwy0m2k 134 6 preventing prevent VBG cord-015922-5wwy0m2k 134 7 CMV CMV NNP cord-015922-5wwy0m2k 134 8 disease disease NN cord-015922-5wwy0m2k 134 9 through through IN cord-015922-5wwy0m2k 134 10 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 134 11 or or CC cord-015922-5wwy0m2k 134 12 preemption preemption NN cord-015922-5wwy0m2k 134 13 . . . cord-015922-5wwy0m2k 135 1 Prophylaxis prophylaxis NN cord-015922-5wwy0m2k 135 2 with with IN cord-015922-5wwy0m2k 135 3 ganciclovir ganciclovir NNS cord-015922-5wwy0m2k 135 4 from from IN cord-015922-5wwy0m2k 135 5 the the DT cord-015922-5wwy0m2k 135 6 time time NN cord-015922-5wwy0m2k 135 7 of of IN cord-015922-5wwy0m2k 135 8 engraftment engraftment NN cord-015922-5wwy0m2k 135 9 until until IN cord-015922-5wwy0m2k 135 10 at at IN cord-015922-5wwy0m2k 135 11 least least JJS cord-015922-5wwy0m2k 135 12 day day NN cord-015922-5wwy0m2k 135 13 100 100 CD cord-015922-5wwy0m2k 135 14 post post JJ cord-015922-5wwy0m2k 135 15 - - NN cord-015922-5wwy0m2k 135 16 transplant transplant NN cord-015922-5wwy0m2k 135 17 has have VBZ cord-015922-5wwy0m2k 135 18 been be VBN cord-015922-5wwy0m2k 135 19 studied study VBN cord-015922-5wwy0m2k 135 20 in in IN cord-015922-5wwy0m2k 135 21 randomized randomized JJ cord-015922-5wwy0m2k 135 22 trials trial NNS cord-015922-5wwy0m2k 135 23 [ [ -LRB- cord-015922-5wwy0m2k 135 24 35 35 CD cord-015922-5wwy0m2k 135 25 , , , cord-015922-5wwy0m2k 135 26 36 36 CD cord-015922-5wwy0m2k 135 27 ] ] -RRB- cord-015922-5wwy0m2k 135 28 . . . cord-015922-5wwy0m2k 136 1 Although although IN cord-015922-5wwy0m2k 136 2 CMV CMV NNP cord-015922-5wwy0m2k 136 3 viremia viremia NN cord-015922-5wwy0m2k 136 4 and and CC cord-015922-5wwy0m2k 136 5 disease disease NN cord-015922-5wwy0m2k 136 6 were be VBD cord-015922-5wwy0m2k 136 7 prevented prevent VBN cord-015922-5wwy0m2k 136 8 , , , cord-015922-5wwy0m2k 136 9 there there EX cord-015922-5wwy0m2k 136 10 was be VBD cord-015922-5wwy0m2k 136 11 no no DT cord-015922-5wwy0m2k 136 12 overall overall JJ cord-015922-5wwy0m2k 136 13 benefit benefit NN cord-015922-5wwy0m2k 136 14 of of IN cord-015922-5wwy0m2k 136 15 this this DT cord-015922-5wwy0m2k 136 16 strategy strategy NN cord-015922-5wwy0m2k 136 17 due due IN cord-015922-5wwy0m2k 136 18 to to IN cord-015922-5wwy0m2k 136 19 secondary secondary JJ cord-015922-5wwy0m2k 136 20 bacterial bacterial NN cord-015922-5wwy0m2k 136 21 and and CC cord-015922-5wwy0m2k 136 22 fungal fungal JJ cord-015922-5wwy0m2k 136 23 infections infection NNS cord-015922-5wwy0m2k 136 24 related relate VBN cord-015922-5wwy0m2k 136 25 to to IN cord-015922-5wwy0m2k 136 26 ganciclovir ganciclovir NN cord-015922-5wwy0m2k 136 27 - - HYPH cord-015922-5wwy0m2k 136 28 induced induce VBN cord-015922-5wwy0m2k 136 29 neutropenia neutropenia NN cord-015922-5wwy0m2k 136 30 . . . cord-015922-5wwy0m2k 137 1 Alternatively alternatively RB cord-015922-5wwy0m2k 137 2 , , , cord-015922-5wwy0m2k 137 3 a a DT cord-015922-5wwy0m2k 137 4 preemptive preemptive JJ cord-015922-5wwy0m2k 137 5 strategy strategy NN cord-015922-5wwy0m2k 137 6 is be VBZ cord-015922-5wwy0m2k 137 7 employed employ VBN cord-015922-5wwy0m2k 137 8 in in IN cord-015922-5wwy0m2k 137 9 which which WDT cord-015922-5wwy0m2k 137 10 patients patient NNS cord-015922-5wwy0m2k 137 11 are be VBP cord-015922-5wwy0m2k 137 12 monitored monitor VBN cord-015922-5wwy0m2k 137 13 weekly weekly RB cord-015922-5wwy0m2k 137 14 for for IN cord-015922-5wwy0m2k 137 15 viremia viremia NN cord-015922-5wwy0m2k 137 16 through through IN cord-015922-5wwy0m2k 137 17 either either CC cord-015922-5wwy0m2k 137 18 a a DT cord-015922-5wwy0m2k 137 19 PCR PCR NNP cord-015922-5wwy0m2k 137 20 assay assay NN cord-015922-5wwy0m2k 137 21 for for IN cord-015922-5wwy0m2k 137 22 CMV CMV NNP cord-015922-5wwy0m2k 137 23 DNA DNA NNP cord-015922-5wwy0m2k 137 24 or or CC cord-015922-5wwy0m2k 137 25 an an DT cord-015922-5wwy0m2k 137 26 antigenemia antigenemia NN cord-015922-5wwy0m2k 137 27 assay assay NN cord-015922-5wwy0m2k 137 28 . . . cord-015922-5wwy0m2k 138 1 Positive positive JJ cord-015922-5wwy0m2k 138 2 results result NNS cord-015922-5wwy0m2k 138 3 are be VBP cord-015922-5wwy0m2k 138 4 linked link VBN cord-015922-5wwy0m2k 138 5 to to IN cord-015922-5wwy0m2k 138 6 initiating initiate VBG cord-015922-5wwy0m2k 138 7 ganciclovir ganciclovir NNS cord-015922-5wwy0m2k 138 8 or or CC cord-015922-5wwy0m2k 138 9 other other JJ cord-015922-5wwy0m2k 138 10 antiviral antiviral JJ cord-015922-5wwy0m2k 138 11 drugs drug NNS cord-015922-5wwy0m2k 138 12 active active JJ cord-015922-5wwy0m2k 138 13 against against IN cord-015922-5wwy0m2k 138 14 CMV CMV NNP cord-015922-5wwy0m2k 138 15 . . . cord-015922-5wwy0m2k 139 1 Typically typically RB cord-015922-5wwy0m2k 139 2 , , , cord-015922-5wwy0m2k 139 3 these these DT cord-015922-5wwy0m2k 139 4 assays assay NNS cord-015922-5wwy0m2k 139 5 turn turn VBP cord-015922-5wwy0m2k 139 6 positive positive JJ cord-015922-5wwy0m2k 139 7 several several JJ cord-015922-5wwy0m2k 139 8 days day NNS cord-015922-5wwy0m2k 139 9 to to IN cord-015922-5wwy0m2k 139 10 weeks week NNS cord-015922-5wwy0m2k 139 11 prior prior RB cord-015922-5wwy0m2k 139 12 to to IN cord-015922-5wwy0m2k 139 13 the the DT cord-015922-5wwy0m2k 139 14 onset onset NN cord-015922-5wwy0m2k 139 15 of of IN cord-015922-5wwy0m2k 139 16 clinical clinical JJ cord-015922-5wwy0m2k 139 17 disease disease NN cord-015922-5wwy0m2k 139 18 , , , cord-015922-5wwy0m2k 139 19 permitting permit VBG cord-015922-5wwy0m2k 139 20 the the DT cord-015922-5wwy0m2k 139 21 use use NN cord-015922-5wwy0m2k 139 22 of of IN cord-015922-5wwy0m2k 139 23 effective effective JJ cord-015922-5wwy0m2k 139 24 preemptive preemptive JJ cord-015922-5wwy0m2k 139 25 therapy therapy NN cord-015922-5wwy0m2k 139 26 [ [ -LRB- cord-015922-5wwy0m2k 139 27 1 1 CD cord-015922-5wwy0m2k 139 28 , , , cord-015922-5wwy0m2k 139 29 4 4 CD cord-015922-5wwy0m2k 139 30 , , , cord-015922-5wwy0m2k 139 31 29 29 CD cord-015922-5wwy0m2k 139 32 , , , cord-015922-5wwy0m2k 139 33 33 33 CD cord-015922-5wwy0m2k 139 34 , , , cord-015922-5wwy0m2k 139 35 [ [ -LRB- cord-015922-5wwy0m2k 139 36 37 37 CD cord-015922-5wwy0m2k 139 37 ] ] -RRB- cord-015922-5wwy0m2k 139 38 [ [ -LRB- cord-015922-5wwy0m2k 139 39 38 38 CD cord-015922-5wwy0m2k 139 40 ] ] -RRB- cord-015922-5wwy0m2k 139 41 [ [ -LRB- cord-015922-5wwy0m2k 139 42 39 39 CD cord-015922-5wwy0m2k 139 43 ] ] -RRB- cord-015922-5wwy0m2k 139 44 [ [ -LRB- cord-015922-5wwy0m2k 139 45 40 40 CD cord-015922-5wwy0m2k 139 46 ] ] -RRB- cord-015922-5wwy0m2k 139 47 [ [ -LRB- cord-015922-5wwy0m2k 139 48 41 41 CD cord-015922-5wwy0m2k 139 49 ] ] -RRB- cord-015922-5wwy0m2k 139 50 . . . cord-015922-5wwy0m2k 140 1 A a DT cord-015922-5wwy0m2k 140 2 preemptive preemptive JJ cord-015922-5wwy0m2k 140 3 approach approach NN cord-015922-5wwy0m2k 140 4 significantly significantly RB cord-015922-5wwy0m2k 140 5 decreases decrease VBZ cord-015922-5wwy0m2k 140 6 the the DT cord-015922-5wwy0m2k 140 7 amount amount NN cord-015922-5wwy0m2k 140 8 of of IN cord-015922-5wwy0m2k 140 9 prophylactic prophylactic JJ cord-015922-5wwy0m2k 140 10 medication medication NN cord-015922-5wwy0m2k 140 11 used use VBN cord-015922-5wwy0m2k 140 12 , , , cord-015922-5wwy0m2k 140 13 thus thus RB cord-015922-5wwy0m2k 140 14 minimizing minimize VBG cord-015922-5wwy0m2k 140 15 medication medication NN cord-015922-5wwy0m2k 140 16 - - HYPH cord-015922-5wwy0m2k 140 17 associated associate VBN cord-015922-5wwy0m2k 140 18 toxicity toxicity NN cord-015922-5wwy0m2k 140 19 . . . cord-015922-5wwy0m2k 141 1 In in IN cord-015922-5wwy0m2k 141 2 the the DT cord-015922-5wwy0m2k 141 3 pre pre JJ cord-015922-5wwy0m2k 141 4 - - JJ cord-015922-5wwy0m2k 141 5 ganciclovir ganciclovir JJ cord-015922-5wwy0m2k 141 6 era era NN cord-015922-5wwy0m2k 141 7 , , , cord-015922-5wwy0m2k 141 8 CMV CMV NNP cord-015922-5wwy0m2k 141 9 disease disease NN cord-015922-5wwy0m2k 141 10 typically typically RB cord-015922-5wwy0m2k 141 11 occurred occur VBD cord-015922-5wwy0m2k 141 12 during during IN cord-015922-5wwy0m2k 141 13 the the DT cord-015922-5wwy0m2k 141 14 first first JJ cord-015922-5wwy0m2k 141 15 three three CD cord-015922-5wwy0m2k 141 16 months month NNS cord-015922-5wwy0m2k 141 17 post post NN cord-015922-5wwy0m2k 141 18 - - NN cord-015922-5wwy0m2k 141 19 transplant transplant NN cord-015922-5wwy0m2k 141 20 . . . cord-015922-5wwy0m2k 142 1 Increasingly increasingly RB cord-015922-5wwy0m2k 142 2 , , , cord-015922-5wwy0m2k 142 3 with with IN cord-015922-5wwy0m2k 142 4 the the DT cord-015922-5wwy0m2k 142 5 widespread widespread JJ cord-015922-5wwy0m2k 142 6 use use NN cord-015922-5wwy0m2k 142 7 of of IN cord-015922-5wwy0m2k 142 8 a a DT cord-015922-5wwy0m2k 142 9 prophylactic prophylactic JJ cord-015922-5wwy0m2k 142 10 or or CC cord-015922-5wwy0m2k 142 11 preemptive preemptive JJ cord-015922-5wwy0m2k 142 12 antiviral antiviral JJ cord-015922-5wwy0m2k 142 13 strategy strategy NN cord-015922-5wwy0m2k 142 14 , , , cord-015922-5wwy0m2k 142 15 breakthrough breakthrough NN cord-015922-5wwy0m2k 142 16 occurs occur VBZ cord-015922-5wwy0m2k 142 17 much much RB cord-015922-5wwy0m2k 142 18 later later RB cord-015922-5wwy0m2k 142 19 , , , cord-015922-5wwy0m2k 142 20 typically typically RB cord-015922-5wwy0m2k 142 21 one one CD cord-015922-5wwy0m2k 142 22 to to TO cord-015922-5wwy0m2k 142 23 three three CD cord-015922-5wwy0m2k 142 24 months month NNS cord-015922-5wwy0m2k 142 25 after after IN cord-015922-5wwy0m2k 142 26 the the DT cord-015922-5wwy0m2k 142 27 cessation cessation NN cord-015922-5wwy0m2k 142 28 of of IN cord-015922-5wwy0m2k 142 29 the the DT cord-015922-5wwy0m2k 142 30 antiviral antiviral JJ cord-015922-5wwy0m2k 142 31 therapy therapy NN cord-015922-5wwy0m2k 142 32 . . . cord-015922-5wwy0m2k 143 1 Risk risk NN cord-015922-5wwy0m2k 143 2 factors factor NNS cord-015922-5wwy0m2k 143 3 for for IN cord-015922-5wwy0m2k 143 4 late late JJ cord-015922-5wwy0m2k 143 5 CMV CMV NNP cord-015922-5wwy0m2k 143 6 disease disease NN cord-015922-5wwy0m2k 143 7 include include VBP cord-015922-5wwy0m2k 143 8 chronic chronic JJ cord-015922-5wwy0m2k 143 9 GVHD GVHD NNP cord-015922-5wwy0m2k 143 10 , , , cord-015922-5wwy0m2k 143 11 low low JJ cord-015922-5wwy0m2k 143 12 CD4-T CD4-T NNP cord-015922-5wwy0m2k 143 13 cell cell NN cord-015922-5wwy0m2k 143 14 counts count NNS cord-015922-5wwy0m2k 143 15 , , , cord-015922-5wwy0m2k 143 16 and and CC cord-015922-5wwy0m2k 143 17 CMV CMV NNP cord-015922-5wwy0m2k 143 18 infection infection NN cord-015922-5wwy0m2k 143 19 before before IN cord-015922-5wwy0m2k 143 20 day day NN cord-015922-5wwy0m2k 143 21 100 100 CD cord-015922-5wwy0m2k 143 22 . . . cord-015922-5wwy0m2k 144 1 Relapse relapse VB cord-015922-5wwy0m2k 144 2 or or CC cord-015922-5wwy0m2k 144 3 the the DT cord-015922-5wwy0m2k 144 4 emergence emergence NN cord-015922-5wwy0m2k 144 5 of of IN cord-015922-5wwy0m2k 144 6 ganciclovirresistant ganciclovirresistant JJ cord-015922-5wwy0m2k 144 7 virus virus NN cord-015922-5wwy0m2k 144 8 also also RB cord-015922-5wwy0m2k 144 9 can can MD cord-015922-5wwy0m2k 144 10 occur occur VB cord-015922-5wwy0m2k 144 11 , , , cord-015922-5wwy0m2k 144 12 particularly particularly RB cord-015922-5wwy0m2k 144 13 in in IN cord-015922-5wwy0m2k 144 14 the the DT cord-015922-5wwy0m2k 144 15 face face NN cord-015922-5wwy0m2k 144 16 of of IN cord-015922-5wwy0m2k 144 17 high high JJ cord-015922-5wwy0m2k 144 18 viral viral JJ cord-015922-5wwy0m2k 144 19 loads load NNS cord-015922-5wwy0m2k 144 20 and and CC cord-015922-5wwy0m2k 144 21 inadequate inadequate JJ cord-015922-5wwy0m2k 144 22 courses course NNS cord-015922-5wwy0m2k 144 23 or or CC cord-015922-5wwy0m2k 144 24 dosing dosing NN cord-015922-5wwy0m2k 144 25 of of IN cord-015922-5wwy0m2k 144 26 ganciclovir ganciclovir NNS cord-015922-5wwy0m2k 144 27 . . . cord-015922-5wwy0m2k 145 1 Foscarnet foscarnet NN cord-015922-5wwy0m2k 145 2 is be VBZ cord-015922-5wwy0m2k 145 3 the the DT cord-015922-5wwy0m2k 145 4 preferred preferred JJ cord-015922-5wwy0m2k 145 5 drug drug NN cord-015922-5wwy0m2k 145 6 in in IN cord-015922-5wwy0m2k 145 7 this this DT cord-015922-5wwy0m2k 145 8 setting setting NN cord-015922-5wwy0m2k 145 9 or or CC cord-015922-5wwy0m2k 145 10 when when WRB cord-015922-5wwy0m2k 145 11 further further JJ cord-015922-5wwy0m2k 145 12 potential potential JJ cord-015922-5wwy0m2k 145 13 myelosuppression myelosuppression NN cord-015922-5wwy0m2k 145 14 with with IN cord-015922-5wwy0m2k 145 15 ganciclovir ganciclovir NNP cord-015922-5wwy0m2k 145 16 is be VBZ cord-015922-5wwy0m2k 145 17 not not RB cord-015922-5wwy0m2k 145 18 advisable advisable JJ cord-015922-5wwy0m2k 145 19 . . . cord-015922-5wwy0m2k 146 1 The the DT cord-015922-5wwy0m2k 146 2 experience experience NN cord-015922-5wwy0m2k 146 3 with with IN cord-015922-5wwy0m2k 146 4 cidofovir cidofovir NNS cord-015922-5wwy0m2k 146 5 use use VBP cord-015922-5wwy0m2k 146 6 in in IN cord-015922-5wwy0m2k 146 7 the the DT cord-015922-5wwy0m2k 146 8 HSCT HSCT NNP cord-015922-5wwy0m2k 146 9 population population NN cord-015922-5wwy0m2k 146 10 is be VBZ cord-015922-5wwy0m2k 146 11 limited limited JJ cord-015922-5wwy0m2k 146 12 . . . cord-015922-5wwy0m2k 147 1 Both both DT cord-015922-5wwy0m2k 147 2 foscarnet foscarnet NN cord-015922-5wwy0m2k 147 3 and and CC cord-015922-5wwy0m2k 147 4 cidofovir cidofovir NNS cord-015922-5wwy0m2k 147 5 are be VBP cord-015922-5wwy0m2k 147 6 potentially potentially RB cord-015922-5wwy0m2k 147 7 nephrotoxic nephrotoxic JJ cord-015922-5wwy0m2k 147 8 and and CC cord-015922-5wwy0m2k 147 9 should should MD cord-015922-5wwy0m2k 147 10 be be VB cord-015922-5wwy0m2k 147 11 administered administer VBN cord-015922-5wwy0m2k 147 12 with with IN cord-015922-5wwy0m2k 147 13 caution caution NN cord-015922-5wwy0m2k 147 14 [ [ -LRB- cord-015922-5wwy0m2k 147 15 1 1 CD cord-015922-5wwy0m2k 147 16 , , , cord-015922-5wwy0m2k 147 17 4 4 CD cord-015922-5wwy0m2k 147 18 ] ] -RRB- cord-015922-5wwy0m2k 147 19 . . . cord-015922-5wwy0m2k 148 1 Studies study NNS cord-015922-5wwy0m2k 148 2 are be VBP cord-015922-5wwy0m2k 148 3 examining examine VBG cord-015922-5wwy0m2k 148 4 the the DT cord-015922-5wwy0m2k 148 5 emerging emerge VBG cord-015922-5wwy0m2k 148 6 strategies strategy NNS cord-015922-5wwy0m2k 148 7 for for IN cord-015922-5wwy0m2k 148 8 the the DT cord-015922-5wwy0m2k 148 9 management management NN cord-015922-5wwy0m2k 148 10 of of IN cord-015922-5wwy0m2k 148 11 CMV CMV NNP cord-015922-5wwy0m2k 148 12 infection infection NN cord-015922-5wwy0m2k 148 13 and and CC cord-015922-5wwy0m2k 148 14 the the DT cord-015922-5wwy0m2k 148 15 use use NN cord-015922-5wwy0m2k 148 16 of of IN cord-015922-5wwy0m2k 148 17 CMV CMV NNP cord-015922-5wwy0m2k 148 18 vaccines vaccine NNS cord-015922-5wwy0m2k 148 19 in in IN cord-015922-5wwy0m2k 148 20 donors donor NNS cord-015922-5wwy0m2k 148 21 and and CC cord-015922-5wwy0m2k 148 22 recipients recipient NNS cord-015922-5wwy0m2k 148 23 , , , cord-015922-5wwy0m2k 148 24 adoptive adoptive JJ cord-015922-5wwy0m2k 148 25 immunotherapy immunotherapy NN cord-015922-5wwy0m2k 148 26 for for IN cord-015922-5wwy0m2k 148 27 patients patient NNS cord-015922-5wwy0m2k 148 28 with with IN cord-015922-5wwy0m2k 148 29 refractory refractory JJ cord-015922-5wwy0m2k 148 30 or or CC cord-015922-5wwy0m2k 148 31 relapsing relapse VBG cord-015922-5wwy0m2k 148 32 CMV CMV NNP cord-015922-5wwy0m2k 148 33 infection infection NN cord-015922-5wwy0m2k 148 34 and and CC cord-015922-5wwy0m2k 148 35 the the DT cord-015922-5wwy0m2k 148 36 use use NN cord-015922-5wwy0m2k 148 37 of of IN cord-015922-5wwy0m2k 148 38 maribavir maribavir NNP cord-015922-5wwy0m2k 148 39 for for IN cord-015922-5wwy0m2k 148 40 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 148 41 . . . cord-015922-5wwy0m2k 149 1 The the DT cord-015922-5wwy0m2k 149 2 major major JJ cord-015922-5wwy0m2k 149 3 recognizable recognizable JJ cord-015922-5wwy0m2k 149 4 clinical clinical JJ cord-015922-5wwy0m2k 149 5 effect effect NN cord-015922-5wwy0m2k 149 6 of of IN cord-015922-5wwy0m2k 149 7 EBV EBV NNP cord-015922-5wwy0m2k 149 8 in in IN cord-015922-5wwy0m2k 149 9 the the DT cord-015922-5wwy0m2k 149 10 HSCT HSCT NNP cord-015922-5wwy0m2k 149 11 patient patient NN cord-015922-5wwy0m2k 149 12 is be VBZ cord-015922-5wwy0m2k 149 13 in in IN cord-015922-5wwy0m2k 149 14 the the DT cord-015922-5wwy0m2k 149 15 pathogenesis pathogenesis NN cord-015922-5wwy0m2k 149 16 of of IN cord-015922-5wwy0m2k 149 17 PTLD PTLD NNP cord-015922-5wwy0m2k 149 18 . . . cord-015922-5wwy0m2k 150 1 Following follow VBG cord-015922-5wwy0m2k 150 2 the the DT cord-015922-5wwy0m2k 150 3 recovery recovery NN cord-015922-5wwy0m2k 150 4 from from IN cord-015922-5wwy0m2k 150 5 primary primary JJ cord-015922-5wwy0m2k 150 6 EBV EBV NNP cord-015922-5wwy0m2k 150 7 infection infection NN cord-015922-5wwy0m2k 150 8 ( ( -LRB- cord-015922-5wwy0m2k 150 9 > > NFP cord-015922-5wwy0m2k 150 10 95 95 CD cord-015922-5wwy0m2k 150 11 % % NN cord-015922-5wwy0m2k 150 12 of of IN cord-015922-5wwy0m2k 150 13 the the DT cord-015922-5wwy0m2k 150 14 adult adult NN cord-015922-5wwy0m2k 150 15 population population NN cord-015922-5wwy0m2k 150 16 ) ) -RRB- cord-015922-5wwy0m2k 150 17 , , , cord-015922-5wwy0m2k 150 18 ongoing ongoing JJ cord-015922-5wwy0m2k 150 19 lytic lytic JJ cord-015922-5wwy0m2k 150 20 infection infection NN cord-015922-5wwy0m2k 150 21 of of IN cord-015922-5wwy0m2k 150 22 B b NN cord-015922-5wwy0m2k 150 23 - - HYPH cord-015922-5wwy0m2k 150 24 cells cell NNS cord-015922-5wwy0m2k 150 25 occurs occur VBZ cord-015922-5wwy0m2k 150 26 in in IN cord-015922-5wwy0m2k 150 27 the the DT cord-015922-5wwy0m2k 150 28 oropharynx oropharynx NN cord-015922-5wwy0m2k 150 29 , , , cord-015922-5wwy0m2k 150 30 with with IN cord-015922-5wwy0m2k 150 31 latent latent JJ cord-015922-5wwy0m2k 150 32 infection infection NN cord-015922-5wwy0m2k 150 33 of of IN cord-015922-5wwy0m2k 150 34 B b NN cord-015922-5wwy0m2k 150 35 - - HYPH cord-015922-5wwy0m2k 150 36 cells cell NNS cord-015922-5wwy0m2k 150 37 in in IN cord-015922-5wwy0m2k 150 38 the the DT cord-015922-5wwy0m2k 150 39 peripheral peripheral JJ cord-015922-5wwy0m2k 150 40 blood blood NN cord-015922-5wwy0m2k 150 41 and and CC cord-015922-5wwy0m2k 150 42 lymphoid lymphoid JJ cord-015922-5wwy0m2k 150 43 tissues tissue NNS cord-015922-5wwy0m2k 150 44 . . . cord-015922-5wwy0m2k 151 1 These these DT cord-015922-5wwy0m2k 151 2 latently latently RB cord-015922-5wwy0m2k 151 3 infected infected JJ cord-015922-5wwy0m2k 151 4 cells cell NNS cord-015922-5wwy0m2k 151 5 can can MD cord-015922-5wwy0m2k 151 6 be be VB cord-015922-5wwy0m2k 151 7 transformed transform VBN cord-015922-5wwy0m2k 151 8 and and CC cord-015922-5wwy0m2k 151 9 immortalized immortalize VBN cord-015922-5wwy0m2k 151 10 , , , cord-015922-5wwy0m2k 151 11 resulting result VBG cord-015922-5wwy0m2k 151 12 in in IN cord-015922-5wwy0m2k 151 13 polyclonal polyclonal JJ cord-015922-5wwy0m2k 151 14 proliferation proliferation NN cord-015922-5wwy0m2k 151 15 . . . cord-015922-5wwy0m2k 152 1 In in IN cord-015922-5wwy0m2k 152 2 the the DT cord-015922-5wwy0m2k 152 3 normal normal JJ cord-015922-5wwy0m2k 152 4 seropositive seropositive JJ cord-015922-5wwy0m2k 152 5 individual individual NN cord-015922-5wwy0m2k 152 6 , , , cord-015922-5wwy0m2k 152 7 these these DT cord-015922-5wwy0m2k 152 8 cells cell NNS cord-015922-5wwy0m2k 152 9 are be VBP cord-015922-5wwy0m2k 152 10 kept keep VBN cord-015922-5wwy0m2k 152 11 in in IN cord-015922-5wwy0m2k 152 12 check check NN cord-015922-5wwy0m2k 152 13 by by IN cord-015922-5wwy0m2k 152 14 a a DT cord-015922-5wwy0m2k 152 15 specific specific JJ cord-015922-5wwy0m2k 152 16 cytotoxic cytotoxic JJ cord-015922-5wwy0m2k 152 17 T t NN cord-015922-5wwy0m2k 152 18 cell cell NN cord-015922-5wwy0m2k 152 19 response response NN cord-015922-5wwy0m2k 152 20 . . . cord-015922-5wwy0m2k 153 1 In in IN cord-015922-5wwy0m2k 153 2 the the DT cord-015922-5wwy0m2k 153 3 presence presence NN cord-015922-5wwy0m2k 153 4 of of IN cord-015922-5wwy0m2k 153 5 immunosuppressive immunosuppressive JJ cord-015922-5wwy0m2k 153 6 therapy therapy NN cord-015922-5wwy0m2k 153 7 , , , cord-015922-5wwy0m2k 153 8 this this DT cord-015922-5wwy0m2k 153 9 surveillance surveillance NN cord-015922-5wwy0m2k 153 10 system system NN cord-015922-5wwy0m2k 153 11 is be VBZ cord-015922-5wwy0m2k 153 12 inhibited inhibit VBN cord-015922-5wwy0m2k 153 13 in in IN cord-015922-5wwy0m2k 153 14 a a DT cord-015922-5wwy0m2k 153 15 dose dose RB cord-015922-5wwy0m2k 153 16 - - HYPH cord-015922-5wwy0m2k 153 17 related relate VBN cord-015922-5wwy0m2k 153 18 fashion fashion NN cord-015922-5wwy0m2k 153 19 , , , cord-015922-5wwy0m2k 153 20 thus thus RB cord-015922-5wwy0m2k 153 21 permitting permit VBG cord-015922-5wwy0m2k 153 22 continued continue VBN cord-015922-5wwy0m2k 153 23 B b NN cord-015922-5wwy0m2k 153 24 - - HYPH cord-015922-5wwy0m2k 153 25 cell cell NN cord-015922-5wwy0m2k 153 26 proliferation proliferation NN cord-015922-5wwy0m2k 153 27 . . . cord-015922-5wwy0m2k 154 1 Such such JJ cord-015922-5wwy0m2k 154 2 ongoing ongoing JJ cord-015922-5wwy0m2k 154 3 proliferation proliferation NN cord-015922-5wwy0m2k 154 4 results result NNS cord-015922-5wwy0m2k 154 5 in in IN cord-015922-5wwy0m2k 154 6 particular particular JJ cord-015922-5wwy0m2k 154 7 clones clone NNS cord-015922-5wwy0m2k 154 8 being be VBG cord-015922-5wwy0m2k 154 9 favored favor VBN cord-015922-5wwy0m2k 154 10 and and CC cord-015922-5wwy0m2k 154 11 the the DT cord-015922-5wwy0m2k 154 12 potential potential NN cord-015922-5wwy0m2k 154 13 for for IN cord-015922-5wwy0m2k 154 14 developing develop VBG cord-015922-5wwy0m2k 154 15 cytogenetic cytogenetic JJ cord-015922-5wwy0m2k 154 16 abnormalities abnormality NNS cord-015922-5wwy0m2k 154 17 , , , cord-015922-5wwy0m2k 154 18 which which WDT cord-015922-5wwy0m2k 154 19 leads lead VBZ cord-015922-5wwy0m2k 154 20 to to IN cord-015922-5wwy0m2k 154 21 the the DT cord-015922-5wwy0m2k 154 22 development development NN cord-015922-5wwy0m2k 154 23 of of IN cord-015922-5wwy0m2k 154 24 a a DT cord-015922-5wwy0m2k 154 25 truly truly RB cord-015922-5wwy0m2k 154 26 malignant malignant JJ cord-015922-5wwy0m2k 154 27 process process NN cord-015922-5wwy0m2k 154 28 - - : cord-015922-5wwy0m2k 154 29 PTLD PTLD NNP cord-015922-5wwy0m2k 154 30 [ [ -LRB- cord-015922-5wwy0m2k 154 31 1 1 CD cord-015922-5wwy0m2k 154 32 , , , cord-015922-5wwy0m2k 154 33 4 4 CD cord-015922-5wwy0m2k 154 34 , , , cord-015922-5wwy0m2k 154 35 27 27 CD cord-015922-5wwy0m2k 154 36 , , , cord-015922-5wwy0m2k 154 37 42 42 CD cord-015922-5wwy0m2k 154 38 ] ] -RRB- cord-015922-5wwy0m2k 154 39 . . . cord-015922-5wwy0m2k 155 1 The the DT cord-015922-5wwy0m2k 155 2 spectrum spectrum NN cord-015922-5wwy0m2k 155 3 of of IN cord-015922-5wwy0m2k 155 4 clinical clinical JJ cord-015922-5wwy0m2k 155 5 disease disease NN cord-015922-5wwy0m2k 155 6 seen see VBN cord-015922-5wwy0m2k 155 7 with with IN cord-015922-5wwy0m2k 155 8 PTLD PTLD NNP cord-015922-5wwy0m2k 155 9 is be VBZ cord-015922-5wwy0m2k 155 10 quite quite RB cord-015922-5wwy0m2k 155 11 broad broad JJ cord-015922-5wwy0m2k 155 12 , , , cord-015922-5wwy0m2k 155 13 ranging range VBG cord-015922-5wwy0m2k 155 14 from from IN cord-015922-5wwy0m2k 155 15 a a DT cord-015922-5wwy0m2k 155 16 mononucleosis mononucleosis NN cord-015922-5wwy0m2k 155 17 - - HYPH cord-015922-5wwy0m2k 155 18 like like JJ cord-015922-5wwy0m2k 155 19 process process NN cord-015922-5wwy0m2k 155 20 or or CC cord-015922-5wwy0m2k 155 21 a a DT cord-015922-5wwy0m2k 155 22 polyclonal polyclonal JJ cord-015922-5wwy0m2k 155 23 proliferation proliferation NN cord-015922-5wwy0m2k 155 24 of of IN cord-015922-5wwy0m2k 155 25 lymphocytes lymphocyte NNS cord-015922-5wwy0m2k 155 26 that that WDT cord-015922-5wwy0m2k 155 27 usually usually RB cord-015922-5wwy0m2k 155 28 responds respond VBZ cord-015922-5wwy0m2k 155 29 to to IN cord-015922-5wwy0m2k 155 30 decreasing decrease VBG cord-015922-5wwy0m2k 155 31 immunosuppressive immunosuppressive JJ cord-015922-5wwy0m2k 155 32 therapy therapy NN cord-015922-5wwy0m2k 155 33 , , , cord-015922-5wwy0m2k 155 34 to to IN cord-015922-5wwy0m2k 155 35 a a DT cord-015922-5wwy0m2k 155 36 monoclonal monoclonal JJ cord-015922-5wwy0m2k 155 37 , , , cord-015922-5wwy0m2k 155 38 highly highly RB cord-015922-5wwy0m2k 155 39 malignant malignant JJ cord-015922-5wwy0m2k 155 40 B b NN cord-015922-5wwy0m2k 155 41 - - HYPH cord-015922-5wwy0m2k 155 42 cell cell NN cord-015922-5wwy0m2k 155 43 lymphoma lymphoma NN cord-015922-5wwy0m2k 155 44 . . . cord-015922-5wwy0m2k 156 1 The the DT cord-015922-5wwy0m2k 156 2 mononucleosis mononucleosis NN cord-015922-5wwy0m2k 156 3 - - HYPH cord-015922-5wwy0m2k 156 4 like like JJ cord-015922-5wwy0m2k 156 5 process process NN cord-015922-5wwy0m2k 156 6 is be VBZ cord-015922-5wwy0m2k 156 7 seen see VBN cord-015922-5wwy0m2k 156 8 particularly particularly RB cord-015922-5wwy0m2k 156 9 in in IN cord-015922-5wwy0m2k 156 10 children child NNS cord-015922-5wwy0m2k 156 11 with with IN cord-015922-5wwy0m2k 156 12 primary primary JJ cord-015922-5wwy0m2k 156 13 post post JJ cord-015922-5wwy0m2k 156 14 - - JJ cord-015922-5wwy0m2k 156 15 transplant transplant JJ cord-015922-5wwy0m2k 156 16 EBV EBV NNP cord-015922-5wwy0m2k 156 17 infection infection NN cord-015922-5wwy0m2k 156 18 . . . cord-015922-5wwy0m2k 157 1 The the DT cord-015922-5wwy0m2k 157 2 clinical clinical JJ cord-015922-5wwy0m2k 157 3 presentation presentation NN cord-015922-5wwy0m2k 157 4 is be VBZ cord-015922-5wwy0m2k 157 5 one one CD cord-015922-5wwy0m2k 157 6 of of IN cord-015922-5wwy0m2k 157 7 fever fever NN cord-015922-5wwy0m2k 157 8 , , , cord-015922-5wwy0m2k 157 9 sore sore JJ cord-015922-5wwy0m2k 157 10 throat throat NN cord-015922-5wwy0m2k 157 11 , , , cord-015922-5wwy0m2k 157 12 cervical cervical JJ cord-015922-5wwy0m2k 157 13 adenopathy adenopathy NN cord-015922-5wwy0m2k 157 14 and and CC cord-015922-5wwy0m2k 157 15 tonsillar tonsillar JJ cord-015922-5wwy0m2k 157 16 hypertrophy hypertrophy NN cord-015922-5wwy0m2k 157 17 and and CC cord-015922-5wwy0m2k 157 18 inflammation inflammation NN cord-015922-5wwy0m2k 157 19 . . . cord-015922-5wwy0m2k 158 1 Unlike unlike IN cord-015922-5wwy0m2k 158 2 B b NN cord-015922-5wwy0m2k 158 3 - - HYPH cord-015922-5wwy0m2k 158 4 cell cell NN cord-015922-5wwy0m2k 158 5 lymphoma lymphoma NN cord-015922-5wwy0m2k 158 6 in in IN cord-015922-5wwy0m2k 158 7 the the DT cord-015922-5wwy0m2k 158 8 normal normal JJ cord-015922-5wwy0m2k 158 9 host host NN cord-015922-5wwy0m2k 158 10 , , , cord-015922-5wwy0m2k 158 11 in in IN cord-015922-5wwy0m2k 158 12 the the DT cord-015922-5wwy0m2k 158 13 transplant transplant NN cord-015922-5wwy0m2k 158 14 patient patient NN cord-015922-5wwy0m2k 158 15 , , , cord-015922-5wwy0m2k 158 16 particularly particularly RB cord-015922-5wwy0m2k 158 17 the the DT cord-015922-5wwy0m2k 158 18 adult adult NN cord-015922-5wwy0m2k 158 19 , , , cord-015922-5wwy0m2k 158 20 the the DT cord-015922-5wwy0m2k 158 21 process process NN cord-015922-5wwy0m2k 158 22 can can MD cord-015922-5wwy0m2k 158 23 be be VB cord-015922-5wwy0m2k 158 24 extranodal extranodal NNP cord-015922-5wwy0m2k 158 25 . . . cord-015922-5wwy0m2k 159 1 Thus thus RB cord-015922-5wwy0m2k 159 2 , , , cord-015922-5wwy0m2k 159 3 presentations presentation NNS cord-015922-5wwy0m2k 159 4 may may MD cord-015922-5wwy0m2k 159 5 include include VB cord-015922-5wwy0m2k 159 6 central central JJ cord-015922-5wwy0m2k 159 7 nervous nervous JJ cord-015922-5wwy0m2k 159 8 system system NN cord-015922-5wwy0m2k 159 9 ( ( -LRB- cord-015922-5wwy0m2k 159 10 CNS CNS NNP cord-015922-5wwy0m2k 159 11 ) ) -RRB- cord-015922-5wwy0m2k 159 12 invasion invasion NN cord-015922-5wwy0m2k 159 13 ( ( -LRB- cord-015922-5wwy0m2k 159 14 from from IN cord-015922-5wwy0m2k 159 15 involvement involvement NN cord-015922-5wwy0m2k 159 16 of of IN cord-015922-5wwy0m2k 159 17 the the DT cord-015922-5wwy0m2k 159 18 meninges meninge NNS cord-015922-5wwy0m2k 159 19 to to IN cord-015922-5wwy0m2k 159 20 focal focal JJ cord-015922-5wwy0m2k 159 21 cerebral cerebral JJ cord-015922-5wwy0m2k 159 22 lesions lesion NNS cord-015922-5wwy0m2k 159 23 ) ) -RRB- cord-015922-5wwy0m2k 159 24 , , , cord-015922-5wwy0m2k 159 25 liver liver NN cord-015922-5wwy0m2k 159 26 , , , cord-015922-5wwy0m2k 159 27 lung lung NN cord-015922-5wwy0m2k 159 28 and and CC cord-015922-5wwy0m2k 159 29 bone bone NN cord-015922-5wwy0m2k 159 30 marrow marrow NN cord-015922-5wwy0m2k 159 31 diseases disease NNS cord-015922-5wwy0m2k 159 32 . . . cord-015922-5wwy0m2k 160 1 Not not RB cord-015922-5wwy0m2k 160 2 uncommonly uncommonly RB cord-015922-5wwy0m2k 160 3 , , , cord-015922-5wwy0m2k 160 4 involvement involvement NN cord-015922-5wwy0m2k 160 5 of of IN cord-015922-5wwy0m2k 160 6 the the DT cord-015922-5wwy0m2k 160 7 gut gut NN cord-015922-5wwy0m2k 160 8 ( ( -LRB- cord-015922-5wwy0m2k 160 9 particularly particularly RB cord-015922-5wwy0m2k 160 10 the the DT cord-015922-5wwy0m2k 160 11 small small JJ cord-015922-5wwy0m2k 160 12 bowel bowel NN cord-015922-5wwy0m2k 160 13 ) ) -RRB- cord-015922-5wwy0m2k 160 14 may may MD cord-015922-5wwy0m2k 160 15 lead lead VB cord-015922-5wwy0m2k 160 16 to to IN cord-015922-5wwy0m2k 160 17 recognition recognition NN cord-015922-5wwy0m2k 160 18 of of IN cord-015922-5wwy0m2k 160 19 the the DT cord-015922-5wwy0m2k 160 20 PTLD PTLD NNP cord-015922-5wwy0m2k 160 21 , , , cord-015922-5wwy0m2k 160 22 with with IN cord-015922-5wwy0m2k 160 23 a a DT cord-015922-5wwy0m2k 160 24 clinical clinical JJ cord-015922-5wwy0m2k 160 25 presentation presentation NN cord-015922-5wwy0m2k 160 26 of of IN cord-015922-5wwy0m2k 160 27 small small JJ cord-015922-5wwy0m2k 160 28 bowel bowel NN cord-015922-5wwy0m2k 160 29 obstruction obstruction NN cord-015922-5wwy0m2k 160 30 , , , cord-015922-5wwy0m2k 160 31 perforation perforation NN cord-015922-5wwy0m2k 160 32 , , , cord-015922-5wwy0m2k 160 33 or or CC cord-015922-5wwy0m2k 160 34 occult occult JJ cord-015922-5wwy0m2k 160 35 gastrointestinal gastrointestinal JJ cord-015922-5wwy0m2k 160 36 bleeding bleeding NN cord-015922-5wwy0m2k 160 37 . . . cord-015922-5wwy0m2k 161 1 Disseminated disseminate VBN cord-015922-5wwy0m2k 161 2 , , , cord-015922-5wwy0m2k 161 3 multi multi JJ cord-015922-5wwy0m2k 161 4 - - JJ cord-015922-5wwy0m2k 161 5 organ organ JJ cord-015922-5wwy0m2k 161 6 disease disease NN cord-015922-5wwy0m2k 161 7 is be VBZ cord-015922-5wwy0m2k 161 8 quite quite RB cord-015922-5wwy0m2k 161 9 common common JJ cord-015922-5wwy0m2k 161 10 in in IN cord-015922-5wwy0m2k 161 11 the the DT cord-015922-5wwy0m2k 161 12 HSCT HSCT NNP cord-015922-5wwy0m2k 161 13 patient patient NN cord-015922-5wwy0m2k 161 14 [ [ -LRB- cord-015922-5wwy0m2k 161 15 1 1 CD cord-015922-5wwy0m2k 161 16 , , , cord-015922-5wwy0m2k 161 17 4 4 CD cord-015922-5wwy0m2k 161 18 , , , cord-015922-5wwy0m2k 161 19 41 41 CD cord-015922-5wwy0m2k 161 20 , , , cord-015922-5wwy0m2k 161 21 42 42 CD cord-015922-5wwy0m2k 161 22 ] ] -RRB- cord-015922-5wwy0m2k 161 23 . . . cord-015922-5wwy0m2k 162 1 Risk risk NN cord-015922-5wwy0m2k 162 2 factors factor NNS cord-015922-5wwy0m2k 162 3 for for IN cord-015922-5wwy0m2k 162 4 developing develop VBG cord-015922-5wwy0m2k 162 5 PTLD PTLD NNP cord-015922-5wwy0m2k 162 6 include include VBP cord-015922-5wwy0m2k 162 7 : : : cord-015922-5wwy0m2k 162 8 primary primary JJ cord-015922-5wwy0m2k 162 9 EBV EBV NNP cord-015922-5wwy0m2k 162 10 infection infection NN cord-015922-5wwy0m2k 162 11 in in IN cord-015922-5wwy0m2k 162 12 association association NN cord-015922-5wwy0m2k 162 13 with with IN cord-015922-5wwy0m2k 162 14 high high JJ cord-015922-5wwy0m2k 162 15 - - HYPH cord-015922-5wwy0m2k 162 16 dose dose NN cord-015922-5wwy0m2k 162 17 immunosuppression immunosuppression NN cord-015922-5wwy0m2k 162 18 ; ; : cord-015922-5wwy0m2k 162 19 interventions intervention NNS cord-015922-5wwy0m2k 162 20 such such JJ cord-015922-5wwy0m2k 162 21 as as IN cord-015922-5wwy0m2k 162 22 T T NNP cord-015922-5wwy0m2k 162 23 cell cell NN cord-015922-5wwy0m2k 162 24 depletion depletion NN cord-015922-5wwy0m2k 162 25 , , , cord-015922-5wwy0m2k 162 26 umbilical umbilical JJ cord-015922-5wwy0m2k 162 27 cord cord NN cord-015922-5wwy0m2k 162 28 blood blood NN cord-015922-5wwy0m2k 162 29 transplant transplant NN cord-015922-5wwy0m2k 162 30 and and CC cord-015922-5wwy0m2k 162 31 the the DT cord-015922-5wwy0m2k 162 32 systemic systemic JJ cord-015922-5wwy0m2k 162 33 administration administration NN cord-015922-5wwy0m2k 162 34 of of IN cord-015922-5wwy0m2k 162 35 anti anti JJ cord-015922-5wwy0m2k 162 36 - - JJ cord-015922-5wwy0m2k 162 37 thymocyte thymocyte JJ cord-015922-5wwy0m2k 162 38 globulin globulin NN cord-015922-5wwy0m2k 162 39 increase increase VBP cord-015922-5wwy0m2k 162 40 the the DT cord-015922-5wwy0m2k 162 41 risk risk NN cord-015922-5wwy0m2k 162 42 significantly significantly RB cord-015922-5wwy0m2k 162 43 ; ; : cord-015922-5wwy0m2k 162 44 and and CC cord-015922-5wwy0m2k 162 45 intensive intensive JJ cord-015922-5wwy0m2k 162 46 immunosuppression immunosuppression NN cord-015922-5wwy0m2k 162 47 that that WDT cord-015922-5wwy0m2k 162 48 results result VBZ cord-015922-5wwy0m2k 162 49 in in IN cord-015922-5wwy0m2k 162 50 suppression suppression NN cord-015922-5wwy0m2k 162 51 of of IN cord-015922-5wwy0m2k 162 52 the the DT cord-015922-5wwy0m2k 162 53 key key JJ cord-015922-5wwy0m2k 162 54 host host NN cord-015922-5wwy0m2k 162 55 defense defense NN cord-015922-5wwy0m2k 162 56 against against IN cord-015922-5wwy0m2k 162 57 EBV EBV NNP cord-015922-5wwy0m2k 162 58 - - HYPH cord-015922-5wwy0m2k 162 59 transformed transform VBN cord-015922-5wwy0m2k 162 60 cells cell NNS cord-015922-5wwy0m2k 163 1 ( ( -LRB- cord-015922-5wwy0m2k 163 2 MHC MHC NNP cord-015922-5wwy0m2k 163 3 - - HYPH cord-015922-5wwy0m2k 163 4 restricted restrict VBN cord-015922-5wwy0m2k 163 5 , , , cord-015922-5wwy0m2k 163 6 EBV EBV NNP cord-015922-5wwy0m2k 163 7 - - HYPH cord-015922-5wwy0m2k 163 8 specific specific JJ cord-015922-5wwy0m2k 163 9 , , , cord-015922-5wwy0m2k 163 10 cytotoxic cytotoxic JJ cord-015922-5wwy0m2k 163 11 T t NN cord-015922-5wwy0m2k 163 12 cells cell NNS cord-015922-5wwy0m2k 163 13 ) ) -RRB- cord-015922-5wwy0m2k 163 14 significantly significantly RB cord-015922-5wwy0m2k 163 15 increases increase VBZ cord-015922-5wwy0m2k 163 16 the the DT cord-015922-5wwy0m2k 163 17 risk risk NN cord-015922-5wwy0m2k 163 18 of of IN cord-015922-5wwy0m2k 163 19 PTLD PTLD NNP cord-015922-5wwy0m2k 163 20 . . . cord-015922-5wwy0m2k 164 1 In in IN cord-015922-5wwy0m2k 164 2 addition addition NN cord-015922-5wwy0m2k 164 3 to to IN cord-015922-5wwy0m2k 164 4 the the DT cord-015922-5wwy0m2k 164 5 host host NN cord-015922-5wwy0m2k 164 6 characteristics characteristic NNS cord-015922-5wwy0m2k 164 7 mentioned mention VBN cord-015922-5wwy0m2k 164 8 , , , cord-015922-5wwy0m2k 164 9 high high JJ cord-015922-5wwy0m2k 164 10 EBV EBV NNP cord-015922-5wwy0m2k 164 11 viral viral JJ cord-015922-5wwy0m2k 164 12 loads load NNS cord-015922-5wwy0m2k 164 13 correlate correlate VBP cord-015922-5wwy0m2k 164 14 with with IN cord-015922-5wwy0m2k 164 15 an an DT cord-015922-5wwy0m2k 164 16 increased increase VBN cord-015922-5wwy0m2k 164 17 risk risk NN cord-015922-5wwy0m2k 164 18 of of IN cord-015922-5wwy0m2k 164 19 PTLD PTLD NNP cord-015922-5wwy0m2k 164 20 . . . cord-015922-5wwy0m2k 165 1 It -PRON- PRP cord-015922-5wwy0m2k 165 2 has have VBZ cord-015922-5wwy0m2k 165 3 been be VBN cord-015922-5wwy0m2k 165 4 suggested suggest VBN cord-015922-5wwy0m2k 165 5 that that IN cord-015922-5wwy0m2k 165 6 EBV EBV NNP cord-015922-5wwy0m2k 165 7 viral viral JJ cord-015922-5wwy0m2k 165 8 load load NN cord-015922-5wwy0m2k 165 9 surveillance surveillance NN cord-015922-5wwy0m2k 165 10 in in IN cord-015922-5wwy0m2k 165 11 peripheral peripheral JJ cord-015922-5wwy0m2k 165 12 blood blood NN cord-015922-5wwy0m2k 165 13 be be VB cord-015922-5wwy0m2k 165 14 carried carry VBN cord-015922-5wwy0m2k 165 15 out out RP cord-015922-5wwy0m2k 165 16 in in IN cord-015922-5wwy0m2k 165 17 high high JJ cord-015922-5wwy0m2k 165 18 risk risk NN cord-015922-5wwy0m2k 165 19 patients patient NNS cord-015922-5wwy0m2k 165 20 ( ( -LRB- cord-015922-5wwy0m2k 165 21 those those DT cord-015922-5wwy0m2k 165 22 with with IN cord-015922-5wwy0m2k 165 23 primary primary JJ cord-015922-5wwy0m2k 165 24 EBV EBV NNP cord-015922-5wwy0m2k 165 25 infection infection NN cord-015922-5wwy0m2k 165 26 , , , cord-015922-5wwy0m2k 165 27 anti anti JJ cord-015922-5wwy0m2k 165 28 - - JJ cord-015922-5wwy0m2k 165 29 T t JJ cord-015922-5wwy0m2k 165 30 cell cell NN cord-015922-5wwy0m2k 165 31 antibody antibody NN cord-015922-5wwy0m2k 165 32 therapy therapy NN cord-015922-5wwy0m2k 165 33 for for IN cord-015922-5wwy0m2k 165 34 GVHD GVHD NNP cord-015922-5wwy0m2k 165 35 , , , cord-015922-5wwy0m2k 165 36 HLA HLA NNP cord-015922-5wwy0m2k 165 37 - - HYPH cord-015922-5wwy0m2k 165 38 mismatched mismatch VBN cord-015922-5wwy0m2k 165 39 or or CC cord-015922-5wwy0m2k 165 40 T t NN cord-015922-5wwy0m2k 165 41 cell cell NN cord-015922-5wwy0m2k 165 42 - - HYPH cord-015922-5wwy0m2k 165 43 depleted deplete VBN cord-015922-5wwy0m2k 165 44 HSCT HSCT NNP cord-015922-5wwy0m2k 165 45 recipients recipient NNS cord-015922-5wwy0m2k 165 46 ) ) -RRB- cord-015922-5wwy0m2k 165 47 , , , cord-015922-5wwy0m2k 165 48 with with IN cord-015922-5wwy0m2k 165 49 decreased decrease VBN cord-015922-5wwy0m2k 165 50 immunosuppression immunosuppression NN cord-015922-5wwy0m2k 165 51 + + CC cord-015922-5wwy0m2k 165 52 /− /− . cord-015922-5wwy0m2k 165 53 antiviral antiviral JJ cord-015922-5wwy0m2k 165 54 therapy therapy NN cord-015922-5wwy0m2k 165 55 ( ( -LRB- cord-015922-5wwy0m2k 165 56 acyclovir acyclovir NNP cord-015922-5wwy0m2k 165 57 or or CC cord-015922-5wwy0m2k 165 58 ganciclovir ganciclovir NNP cord-015922-5wwy0m2k 165 59 ) ) -RRB- cord-015922-5wwy0m2k 165 60 carried carry VBN cord-015922-5wwy0m2k 165 61 out out RP cord-015922-5wwy0m2k 165 62 in in IN cord-015922-5wwy0m2k 165 63 the the DT cord-015922-5wwy0m2k 165 64 setting setting NN cord-015922-5wwy0m2k 165 65 of of IN cord-015922-5wwy0m2k 165 66 high high JJ cord-015922-5wwy0m2k 165 67 viral viral JJ cord-015922-5wwy0m2k 165 68 loads load NNS cord-015922-5wwy0m2k 165 69 [ [ -LRB- cord-015922-5wwy0m2k 165 70 1 1 CD cord-015922-5wwy0m2k 165 71 , , , cord-015922-5wwy0m2k 165 72 4 4 CD cord-015922-5wwy0m2k 165 73 , , , cord-015922-5wwy0m2k 165 74 41 41 CD cord-015922-5wwy0m2k 165 75 , , , cord-015922-5wwy0m2k 165 76 42 42 CD cord-015922-5wwy0m2k 165 77 ] ] -RRB- cord-015922-5wwy0m2k 165 78 . . . cord-015922-5wwy0m2k 166 1 Treatment treatment NN cord-015922-5wwy0m2k 166 2 of of IN cord-015922-5wwy0m2k 166 3 PTLD PTLD NNP cord-015922-5wwy0m2k 166 4 remains remain VBZ cord-015922-5wwy0m2k 166 5 controversial controversial JJ cord-015922-5wwy0m2k 166 6 . . . cord-015922-5wwy0m2k 167 1 All all DT cord-015922-5wwy0m2k 167 2 patients patient NNS cord-015922-5wwy0m2k 167 3 with with IN cord-015922-5wwy0m2k 167 4 diagnosed diagnosed JJ cord-015922-5wwy0m2k 167 5 PTLD PTLD NNP cord-015922-5wwy0m2k 167 6 should should MD cord-015922-5wwy0m2k 167 7 have have VB cord-015922-5wwy0m2k 167 8 a a DT cord-015922-5wwy0m2k 167 9 significant significant JJ cord-015922-5wwy0m2k 167 10 decrease decrease NN cord-015922-5wwy0m2k 167 11 in in IN cord-015922-5wwy0m2k 167 12 immunosuppressive immunosuppressive JJ cord-015922-5wwy0m2k 167 13 medications medication NNS cord-015922-5wwy0m2k 167 14 . . . cord-015922-5wwy0m2k 168 1 Many many JJ cord-015922-5wwy0m2k 168 2 centers center NNS cord-015922-5wwy0m2k 168 3 also also RB cord-015922-5wwy0m2k 168 4 prescribe prescribe VBP cord-015922-5wwy0m2k 168 5 antiviral antiviral JJ cord-015922-5wwy0m2k 168 6 therapy therapy NN cord-015922-5wwy0m2k 168 7 . . . cord-015922-5wwy0m2k 169 1 Patients patient NNS cord-015922-5wwy0m2k 169 2 not not RB cord-015922-5wwy0m2k 169 3 responding respond VBG cord-015922-5wwy0m2k 169 4 to to IN cord-015922-5wwy0m2k 169 5 these these DT cord-015922-5wwy0m2k 169 6 measures measure NNS cord-015922-5wwy0m2k 169 7 are be VBP cord-015922-5wwy0m2k 169 8 usually usually RB cord-015922-5wwy0m2k 169 9 treated treat VBN cord-015922-5wwy0m2k 169 10 with with IN cord-015922-5wwy0m2k 169 11 an an DT cord-015922-5wwy0m2k 169 12 anti anti JJ cord-015922-5wwy0m2k 169 13 - - JJ cord-015922-5wwy0m2k 169 14 B b NN cord-015922-5wwy0m2k 169 15 - - HYPH cord-015922-5wwy0m2k 169 16 cell cell NN cord-015922-5wwy0m2k 169 17 monoclonal monoclonal JJ cord-015922-5wwy0m2k 169 18 antibody antibody NN cord-015922-5wwy0m2k 169 19 ( ( -LRB- cord-015922-5wwy0m2k 169 20 rituximab rituximab NNP cord-015922-5wwy0m2k 169 21 , , , cord-015922-5wwy0m2k 169 22 an an DT cord-015922-5wwy0m2k 169 23 anti anti JJ cord-015922-5wwy0m2k 169 24 - - JJ cord-015922-5wwy0m2k 169 25 CD20 cd20 JJ cord-015922-5wwy0m2k 169 26 monoclonal monoclonal JJ cord-015922-5wwy0m2k 169 27 antibody antibody NN cord-015922-5wwy0m2k 169 28 ) ) -RRB- cord-015922-5wwy0m2k 169 29 [ [ -LRB- cord-015922-5wwy0m2k 169 30 43 43 CD cord-015922-5wwy0m2k 169 31 , , , cord-015922-5wwy0m2k 169 32 44 44 CD cord-015922-5wwy0m2k 169 33 ] ] -RRB- cord-015922-5wwy0m2k 169 34 . . . cord-015922-5wwy0m2k 170 1 After after IN cord-015922-5wwy0m2k 170 2 that that DT cord-015922-5wwy0m2k 170 3 , , , cord-015922-5wwy0m2k 170 4 therapies therapy NNS cord-015922-5wwy0m2k 170 5 have have VBP cord-015922-5wwy0m2k 170 6 ranged range VBN cord-015922-5wwy0m2k 170 7 from from IN cord-015922-5wwy0m2k 170 8 anti anti JJ cord-015922-5wwy0m2k 170 9 - - JJ cord-015922-5wwy0m2k 170 10 lymphoma lymphoma JJ cord-015922-5wwy0m2k 170 11 chemotherapy chemotherapy NN cord-015922-5wwy0m2k 170 12 to to IN cord-015922-5wwy0m2k 170 13 alpha alpha NN cord-015922-5wwy0m2k 170 14 - - HYPH cord-015922-5wwy0m2k 170 15 interferon interferon JJ cord-015922-5wwy0m2k 170 16 and and CC cord-015922-5wwy0m2k 170 17 intravenous intravenous JJ cord-015922-5wwy0m2k 170 18 gamma gamma NN cord-015922-5wwy0m2k 170 19 globulin globulin NN cord-015922-5wwy0m2k 170 20 . . . cord-015922-5wwy0m2k 171 1 HSV HSV NNP cord-015922-5wwy0m2k 171 2 infection infection NN cord-015922-5wwy0m2k 171 3 prior prior RB cord-015922-5wwy0m2k 171 4 to to IN cord-015922-5wwy0m2k 171 5 the the DT cord-015922-5wwy0m2k 171 6 introduction introduction NN cord-015922-5wwy0m2k 171 7 of of IN cord-015922-5wwy0m2k 171 8 acyclovir acyclovir NNP cord-015922-5wwy0m2k 171 9 was be VBD cord-015922-5wwy0m2k 171 10 a a DT cord-015922-5wwy0m2k 171 11 major major JJ cord-015922-5wwy0m2k 171 12 problem problem NN cord-015922-5wwy0m2k 171 13 in in IN cord-015922-5wwy0m2k 171 14 the the DT cord-015922-5wwy0m2k 171 15 HSCT HSCT NNP cord-015922-5wwy0m2k 171 16 recipient recipient NN cord-015922-5wwy0m2k 171 17 . . . cord-015922-5wwy0m2k 172 1 Occurring occur VBG cord-015922-5wwy0m2k 172 2 in in IN cord-015922-5wwy0m2k 172 3 the the DT cord-015922-5wwy0m2k 172 4 preengraftment preengraftment JJ cord-015922-5wwy0m2k 172 5 period period NN cord-015922-5wwy0m2k 172 6 , , , cord-015922-5wwy0m2k 172 7 HSV HSV NNP cord-015922-5wwy0m2k 172 8 infection infection NN cord-015922-5wwy0m2k 172 9 greatly greatly RB cord-015922-5wwy0m2k 172 10 exacerbated exacerbate VBD cord-015922-5wwy0m2k 172 11 the the DT cord-015922-5wwy0m2k 172 12 severity severity NN cord-015922-5wwy0m2k 172 13 of of IN cord-015922-5wwy0m2k 172 14 mucositis mucositis NNP cord-015922-5wwy0m2k 172 15 . . . cord-015922-5wwy0m2k 173 1 Not not RB cord-015922-5wwy0m2k 173 2 only only RB cord-015922-5wwy0m2k 173 3 were be VBD cord-015922-5wwy0m2k 173 4 ulcers ulcer NNS cord-015922-5wwy0m2k 173 5 observed observe VBN cord-015922-5wwy0m2k 173 6 in in IN cord-015922-5wwy0m2k 173 7 the the DT cord-015922-5wwy0m2k 173 8 oral oral JJ cord-015922-5wwy0m2k 173 9 cavity cavity NN cord-015922-5wwy0m2k 173 10 and and CC cord-015922-5wwy0m2k 173 11 anogenital anogenital JJ cord-015922-5wwy0m2k 173 12 areas area NNS cord-015922-5wwy0m2k 173 13 , , , cord-015922-5wwy0m2k 173 14 ulcerations ulceration NNS cord-015922-5wwy0m2k 173 15 of of IN cord-015922-5wwy0m2k 173 16 the the DT cord-015922-5wwy0m2k 173 17 esophagus esophagus NN cord-015922-5wwy0m2k 173 18 , , , cord-015922-5wwy0m2k 173 19 stomach stomach NN cord-015922-5wwy0m2k 173 20 and and CC cord-015922-5wwy0m2k 173 21 intestine intestine NN cord-015922-5wwy0m2k 173 22 were be VBD cord-015922-5wwy0m2k 173 23 also also RB cord-015922-5wwy0m2k 173 24 observed observe VBN cord-015922-5wwy0m2k 173 25 . . . cord-015922-5wwy0m2k 174 1 HSV HSV NNP cord-015922-5wwy0m2k 174 2 pneumonia pneumonia NN cord-015922-5wwy0m2k 174 3 was be VBD cord-015922-5wwy0m2k 174 4 also also RB cord-015922-5wwy0m2k 174 5 noted note VBN cord-015922-5wwy0m2k 174 6 , , , cord-015922-5wwy0m2k 174 7 with with IN cord-015922-5wwy0m2k 174 8 rare rare JJ cord-015922-5wwy0m2k 174 9 cases case NNS cord-015922-5wwy0m2k 174 10 of of IN cord-015922-5wwy0m2k 174 11 cutaneous cutaneous JJ cord-015922-5wwy0m2k 174 12 dissemination dissemination NN cord-015922-5wwy0m2k 174 13 and and CC cord-015922-5wwy0m2k 174 14 encephalitis encephalitis NN cord-015922-5wwy0m2k 174 15 . . . cord-015922-5wwy0m2k 175 1 The the DT cord-015922-5wwy0m2k 175 2 current current JJ cord-015922-5wwy0m2k 175 3 standard standard NN cord-015922-5wwy0m2k 175 4 of of IN cord-015922-5wwy0m2k 175 5 care care NN cord-015922-5wwy0m2k 175 6 is be VBZ cord-015922-5wwy0m2k 175 7 to to TO cord-015922-5wwy0m2k 175 8 test test VB cord-015922-5wwy0m2k 175 9 all all DT cord-015922-5wwy0m2k 175 10 candidates candidate NNS cord-015922-5wwy0m2k 175 11 for for IN cord-015922-5wwy0m2k 175 12 HSCT HSCT NNP cord-015922-5wwy0m2k 175 13 for for IN cord-015922-5wwy0m2k 175 14 an an DT cord-015922-5wwy0m2k 175 15 antibody antibody NN cord-015922-5wwy0m2k 175 16 to to IN cord-015922-5wwy0m2k 175 17 HSV HSV NNP cord-015922-5wwy0m2k 175 18 , , , cord-015922-5wwy0m2k 175 19 with with IN cord-015922-5wwy0m2k 175 20 seropositive seropositive JJ cord-015922-5wwy0m2k 175 21 individuals individual NNS cord-015922-5wwy0m2k 175 22 then then RB cord-015922-5wwy0m2k 175 23 placed place VBD cord-015922-5wwy0m2k 175 24 on on IN cord-015922-5wwy0m2k 175 25 antiviral antiviral JJ cord-015922-5wwy0m2k 175 26 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 175 27 , , , cord-015922-5wwy0m2k 175 28 beginning begin VBG cord-015922-5wwy0m2k 175 29 prior prior RB cord-015922-5wwy0m2k 175 30 to to IN cord-015922-5wwy0m2k 175 31 HSCT HSCT NNP cord-015922-5wwy0m2k 175 32 . . . cord-015922-5wwy0m2k 176 1 Effective effective JJ cord-015922-5wwy0m2k 176 2 agents agent NNS cord-015922-5wwy0m2k 176 3 for for IN cord-015922-5wwy0m2k 176 4 HSV HSV NNP cord-015922-5wwy0m2k 176 5 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 176 6 include include VBP cord-015922-5wwy0m2k 176 7 acyclovir acyclovir NNP cord-015922-5wwy0m2k 176 8 ( ( -LRB- cord-015922-5wwy0m2k 176 9 intravenous intravenous JJ cord-015922-5wwy0m2k 176 10 or or CC cord-015922-5wwy0m2k 176 11 oral oral JJ cord-015922-5wwy0m2k 176 12 ) ) -RRB- cord-015922-5wwy0m2k 176 13 , , , cord-015922-5wwy0m2k 176 14 valacyclovir valacyclovir NNP cord-015922-5wwy0m2k 176 15 or or CC cord-015922-5wwy0m2k 176 16 famciclovir famciclovir NNP cord-015922-5wwy0m2k 176 17 . . . cord-015922-5wwy0m2k 177 1 Recurrence recurrence NN cord-015922-5wwy0m2k 177 2 of of IN cord-015922-5wwy0m2k 177 3 HSV HSV NNP cord-015922-5wwy0m2k 177 4 may may MD cord-015922-5wwy0m2k 177 5 occur occur VB cord-015922-5wwy0m2k 177 6 later later RB cord-015922-5wwy0m2k 177 7 in in IN cord-015922-5wwy0m2k 177 8 the the DT cord-015922-5wwy0m2k 177 9 course course NN cord-015922-5wwy0m2k 177 10 , , , cord-015922-5wwy0m2k 177 11 and and CC cord-015922-5wwy0m2k 177 12 should should MD cord-015922-5wwy0m2k 177 13 again again RB cord-015922-5wwy0m2k 177 14 be be VB cord-015922-5wwy0m2k 177 15 treated treat VBN cord-015922-5wwy0m2k 177 16 with with IN cord-015922-5wwy0m2k 177 17 an an DT cord-015922-5wwy0m2k 177 18 acyclovir acyclovir NNP cord-015922-5wwy0m2k 177 19 regimen regimen NN cord-015922-5wwy0m2k 177 20 , , , cord-015922-5wwy0m2k 177 21 with with IN cord-015922-5wwy0m2k 177 22 repeated repeat VBN cord-015922-5wwy0m2k 177 23 episodes episode NNS cord-015922-5wwy0m2k 177 24 justifying justify VBG cord-015922-5wwy0m2k 177 25 long long JJ cord-015922-5wwy0m2k 177 26 - - HYPH cord-015922-5wwy0m2k 177 27 term term NN cord-015922-5wwy0m2k 177 28 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 177 29 . . . cord-015922-5wwy0m2k 178 1 Acyclovir Acyclovir NNP cord-015922-5wwy0m2k 178 2 resistance resistance NN cord-015922-5wwy0m2k 178 3 is be VBZ cord-015922-5wwy0m2k 178 4 uncommon uncommon JJ cord-015922-5wwy0m2k 178 5 in in IN cord-015922-5wwy0m2k 178 6 this this DT cord-015922-5wwy0m2k 178 7 situation situation NN cord-015922-5wwy0m2k 178 8 , , , cord-015922-5wwy0m2k 178 9 but but CC cord-015922-5wwy0m2k 178 10 can can MD cord-015922-5wwy0m2k 178 11 occur occur VB cord-015922-5wwy0m2k 178 12 , , , cord-015922-5wwy0m2k 178 13 and and CC cord-015922-5wwy0m2k 178 14 requires require VBZ cord-015922-5wwy0m2k 178 15 treatment treatment NN cord-015922-5wwy0m2k 178 16 with with IN cord-015922-5wwy0m2k 178 17 foscarnet foscarnet NN cord-015922-5wwy0m2k 178 18 [ [ -LRB- cord-015922-5wwy0m2k 178 19 1 1 CD cord-015922-5wwy0m2k 178 20 , , , cord-015922-5wwy0m2k 178 21 4 4 CD cord-015922-5wwy0m2k 178 22 ] ] -RRB- cord-015922-5wwy0m2k 178 23 . . . cord-015922-5wwy0m2k 179 1 All all DT cord-015922-5wwy0m2k 179 2 patients patient NNS cord-015922-5wwy0m2k 179 3 and and CC cord-015922-5wwy0m2k 179 4 donors donor NNS cord-015922-5wwy0m2k 179 5 should should MD cord-015922-5wwy0m2k 179 6 have have VB cord-015922-5wwy0m2k 179 7 serologic serologic JJ cord-015922-5wwy0m2k 179 8 testing testing NN cord-015922-5wwy0m2k 179 9 for for IN cord-015922-5wwy0m2k 179 10 VZV VZV NNP cord-015922-5wwy0m2k 179 11 prior prior RB cord-015922-5wwy0m2k 179 12 to to IN cord-015922-5wwy0m2k 179 13 transplant transplant NN cord-015922-5wwy0m2k 179 14 . . . cord-015922-5wwy0m2k 180 1 Seronegative seronegative JJ cord-015922-5wwy0m2k 180 2 individuals individual NNS cord-015922-5wwy0m2k 180 3 post post VBP cord-015922-5wwy0m2k 180 4 - - NN cord-015922-5wwy0m2k 180 5 transplant transplant NN cord-015922-5wwy0m2k 180 6 should should MD cord-015922-5wwy0m2k 180 7 avoid avoid VB cord-015922-5wwy0m2k 180 8 exposures exposure NNS cord-015922-5wwy0m2k 180 9 to to IN cord-015922-5wwy0m2k 180 10 VZV VZV NNP cord-015922-5wwy0m2k 180 11 , , , cord-015922-5wwy0m2k 180 12 but but CC cord-015922-5wwy0m2k 180 13 if if IN cord-015922-5wwy0m2k 180 14 such such PDT cord-015922-5wwy0m2k 180 15 an an DT cord-015922-5wwy0m2k 180 16 exposure exposure NN cord-015922-5wwy0m2k 180 17 occurs occur VBZ cord-015922-5wwy0m2k 180 18 , , , cord-015922-5wwy0m2k 180 19 valacyclovir valacyclovir NNP cord-015922-5wwy0m2k 180 20 or or CC cord-015922-5wwy0m2k 180 21 varicella varicella NNP cord-015922-5wwy0m2k 180 22 hyperimmune hyperimmune NNP cord-015922-5wwy0m2k 180 23 globulin globulin NNP cord-015922-5wwy0m2k 180 24 should should MD cord-015922-5wwy0m2k 180 25 be be VB cord-015922-5wwy0m2k 180 26 promptly promptly RB cord-015922-5wwy0m2k 180 27 initiated initiate VBN cord-015922-5wwy0m2k 180 28 . . . cord-015922-5wwy0m2k 181 1 Before before IN cord-015922-5wwy0m2k 181 2 universal universal JJ cord-015922-5wwy0m2k 181 3 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 181 4 with with IN cord-015922-5wwy0m2k 181 5 acyclovir acyclovir NNP cord-015922-5wwy0m2k 181 6 became become VBD cord-015922-5wwy0m2k 181 7 standard standard JJ cord-015922-5wwy0m2k 181 8 , , , cord-015922-5wwy0m2k 181 9 an an DT cord-015922-5wwy0m2k 181 10 estimated estimate VBN cord-015922-5wwy0m2k 181 11 40 40 CD cord-015922-5wwy0m2k 181 12 percent percent NN cord-015922-5wwy0m2k 181 13 of of IN cord-015922-5wwy0m2k 181 14 HSCT HSCT NNP cord-015922-5wwy0m2k 181 15 patients patient NNS cord-015922-5wwy0m2k 181 16 developed develop VBD cord-015922-5wwy0m2k 181 17 active active JJ cord-015922-5wwy0m2k 181 18 VZV VZV NNP cord-015922-5wwy0m2k 181 19 , , , cord-015922-5wwy0m2k 181 20 with with IN cord-015922-5wwy0m2k 181 21 a a DT cord-015922-5wwy0m2k 181 22 median median JJ cord-015922-5wwy0m2k 181 23 time time NN cord-015922-5wwy0m2k 181 24 of of IN cord-015922-5wwy0m2k 181 25 onset onset NN cord-015922-5wwy0m2k 181 26 being be VBG cord-015922-5wwy0m2k 181 27 five five CD cord-015922-5wwy0m2k 181 28 months month NNS cord-015922-5wwy0m2k 181 29 post post NN cord-015922-5wwy0m2k 181 30 - - NN cord-015922-5wwy0m2k 181 31 transplant transplant NN cord-015922-5wwy0m2k 181 32 . . . cord-015922-5wwy0m2k 182 1 The the DT cord-015922-5wwy0m2k 182 2 great great JJ cord-015922-5wwy0m2k 182 3 majority majority NN cord-015922-5wwy0m2k 182 4 of of IN cord-015922-5wwy0m2k 182 5 these these DT cord-015922-5wwy0m2k 182 6 patients patient NNS cord-015922-5wwy0m2k 182 7 had have VBD cord-015922-5wwy0m2k 182 8 zoster zoster NN cord-015922-5wwy0m2k 182 9 , , , cord-015922-5wwy0m2k 182 10 but but CC cord-015922-5wwy0m2k 182 11 approximately approximately RB cord-015922-5wwy0m2k 182 12 20 20 CD cord-015922-5wwy0m2k 182 13 percent percent NN cord-015922-5wwy0m2k 182 14 had have VBD cord-015922-5wwy0m2k 182 15 a a DT cord-015922-5wwy0m2k 182 16 more more RBR cord-015922-5wwy0m2k 182 17 generalized generalized JJ cord-015922-5wwy0m2k 182 18 process process NN cord-015922-5wwy0m2k 182 19 resembling resemble VBG cord-015922-5wwy0m2k 182 20 primary primary JJ cord-015922-5wwy0m2k 182 21 varicella varicella NN cord-015922-5wwy0m2k 182 22 . . . cord-015922-5wwy0m2k 183 1 A a DT cord-015922-5wwy0m2k 183 2 significant significant JJ cord-015922-5wwy0m2k 183 3 concern concern NN cord-015922-5wwy0m2k 183 4 was be VBD cord-015922-5wwy0m2k 183 5 visceral visceral JJ cord-015922-5wwy0m2k 183 6 involvement involvement NN cord-015922-5wwy0m2k 183 7 in in IN cord-015922-5wwy0m2k 183 8 the the DT cord-015922-5wwy0m2k 183 9 setting setting NN cord-015922-5wwy0m2k 183 10 of of IN cord-015922-5wwy0m2k 183 11 disseminated disseminate VBN cord-015922-5wwy0m2k 183 12 disease disease NN cord-015922-5wwy0m2k 183 13 as as RB cord-015922-5wwy0m2k 183 14 well well RB cord-015922-5wwy0m2k 183 15 as as IN cord-015922-5wwy0m2k 183 16 neurologic neurologic JJ cord-015922-5wwy0m2k 183 17 complications complication NNS cord-015922-5wwy0m2k 183 18 such such JJ cord-015922-5wwy0m2k 183 19 as as IN cord-015922-5wwy0m2k 183 20 myelitis myelitis NNP cord-015922-5wwy0m2k 183 21 or or CC cord-015922-5wwy0m2k 183 22 encephalitis encephalitis JJ cord-015922-5wwy0m2k 183 23 [ [ -LRB- cord-015922-5wwy0m2k 183 24 1 1 CD cord-015922-5wwy0m2k 183 25 , , , cord-015922-5wwy0m2k 183 26 [ [ -LRB- cord-015922-5wwy0m2k 183 27 45 45 CD cord-015922-5wwy0m2k 183 28 ] ] -RRB- cord-015922-5wwy0m2k 183 29 [ [ -LRB- cord-015922-5wwy0m2k 183 30 46 46 CD cord-015922-5wwy0m2k 183 31 ] ] -RRB- cord-015922-5wwy0m2k 183 32 [ [ -LRB- cord-015922-5wwy0m2k 183 33 47 47 CD cord-015922-5wwy0m2k 183 34 ] ] -RRB- cord-015922-5wwy0m2k 183 35 [ [ -LRB- cord-015922-5wwy0m2k 183 36 48 48 CD cord-015922-5wwy0m2k 183 37 ] ] -RRB- cord-015922-5wwy0m2k 183 38 . . . cord-015922-5wwy0m2k 184 1 Prophylaxis Prophylaxis NNP cord-015922-5wwy0m2k 184 2 with with IN cord-015922-5wwy0m2k 184 3 acyclovir acyclovir NNP cord-015922-5wwy0m2k 184 4 in in IN cord-015922-5wwy0m2k 184 5 the the DT cord-015922-5wwy0m2k 184 6 early early JJ cord-015922-5wwy0m2k 184 7 period period NN cord-015922-5wwy0m2k 184 8 post post NN cord-015922-5wwy0m2k 184 9 - - NN cord-015922-5wwy0m2k 184 10 transplantation transplantation NN cord-015922-5wwy0m2k 184 11 substantially substantially RB cord-015922-5wwy0m2k 184 12 decreases decrease VBZ cord-015922-5wwy0m2k 184 13 the the DT cord-015922-5wwy0m2k 184 14 occurrence occurrence NN cord-015922-5wwy0m2k 184 15 of of IN cord-015922-5wwy0m2k 184 16 herpesvirus herpesvirus NN cord-015922-5wwy0m2k 184 17 infections infection NNS cord-015922-5wwy0m2k 184 18 , , , cord-015922-5wwy0m2k 184 19 including include VBG cord-015922-5wwy0m2k 184 20 VZV VZV NNP cord-015922-5wwy0m2k 184 21 , , , cord-015922-5wwy0m2k 184 22 and and CC cord-015922-5wwy0m2k 184 23 is be VBZ cord-015922-5wwy0m2k 184 24 rarely rarely RB cord-015922-5wwy0m2k 184 25 , , , cord-015922-5wwy0m2k 184 26 if if IN cord-015922-5wwy0m2k 184 27 ever ever RB cord-015922-5wwy0m2k 184 28 , , , cord-015922-5wwy0m2k 184 29 seen see VBN cord-015922-5wwy0m2k 184 30 during during IN cord-015922-5wwy0m2k 184 31 acyclovir acyclovir NNP cord-015922-5wwy0m2k 184 32 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 184 33 . . . cord-015922-5wwy0m2k 185 1 Prophylaxis Prophylaxis NNP cord-015922-5wwy0m2k 185 2 is be VBZ cord-015922-5wwy0m2k 185 3 typically typically RB cord-015922-5wwy0m2k 185 4 given give VBN cord-015922-5wwy0m2k 185 5 for for IN cord-015922-5wwy0m2k 185 6 the the DT cord-015922-5wwy0m2k 185 7 first first JJ cord-015922-5wwy0m2k 185 8 year year NN cord-015922-5wwy0m2k 185 9 post post NN cord-015922-5wwy0m2k 185 10 - - JJ cord-015922-5wwy0m2k 185 11 allogeniec allogeniec JJ cord-015922-5wwy0m2k 185 12 transplantation transplantation NN cord-015922-5wwy0m2k 185 13 . . . cord-015922-5wwy0m2k 186 1 VZV VZV NNP cord-015922-5wwy0m2k 186 2 reactivation reactivation NN cord-015922-5wwy0m2k 186 3 is be VBZ cord-015922-5wwy0m2k 186 4 often often RB cord-015922-5wwy0m2k 186 5 seen see VBN cord-015922-5wwy0m2k 186 6 three three CD cord-015922-5wwy0m2k 186 7 months month NNS cord-015922-5wwy0m2k 186 8 post post JJ cord-015922-5wwy0m2k 186 9 - - JJ cord-015922-5wwy0m2k 186 10 discontinuation discontinuation NN cord-015922-5wwy0m2k 186 11 of of IN cord-015922-5wwy0m2k 186 12 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 186 13 . . . cord-015922-5wwy0m2k 187 1 As as IN cord-015922-5wwy0m2k 187 2 the the DT cord-015922-5wwy0m2k 187 3 VZV VZV NNP cord-015922-5wwy0m2k 187 4 vaccine vaccine NN cord-015922-5wwy0m2k 187 5 is be VBZ cord-015922-5wwy0m2k 187 6 a a DT cord-015922-5wwy0m2k 187 7 live live JJ cord-015922-5wwy0m2k 187 8 attenuated attenuate VBN cord-015922-5wwy0m2k 187 9 viral viral JJ cord-015922-5wwy0m2k 187 10 vaccine vaccine NN cord-015922-5wwy0m2k 187 11 , , , cord-015922-5wwy0m2k 187 12 its -PRON- PRP$ cord-015922-5wwy0m2k 187 13 use use NN cord-015922-5wwy0m2k 187 14 is be VBZ cord-015922-5wwy0m2k 187 15 contraindicated contraindicate VBN cord-015922-5wwy0m2k 187 16 for for IN cord-015922-5wwy0m2k 187 17 at at RB cord-015922-5wwy0m2k 187 18 least least RBS cord-015922-5wwy0m2k 187 19 two two CD cord-015922-5wwy0m2k 187 20 years year NNS cord-015922-5wwy0m2k 187 21 posttransplantation posttransplantation NN cord-015922-5wwy0m2k 187 22 , , , cord-015922-5wwy0m2k 187 23 and and CC cord-015922-5wwy0m2k 187 24 unless unless IN cord-015922-5wwy0m2k 187 25 a a DT cord-015922-5wwy0m2k 187 26 research research NN cord-015922-5wwy0m2k 187 27 study study NN cord-015922-5wwy0m2k 187 28 or or CC cord-015922-5wwy0m2k 187 29 close close JJ cord-015922-5wwy0m2k 187 30 follow follow NN cord-015922-5wwy0m2k 187 31 - - HYPH cord-015922-5wwy0m2k 187 32 up up NN cord-015922-5wwy0m2k 187 33 is be VBZ cord-015922-5wwy0m2k 187 34 involved involve VBN cord-015922-5wwy0m2k 187 35 , , , cord-015922-5wwy0m2k 187 36 should should MD cord-015922-5wwy0m2k 187 37 be be VB cord-015922-5wwy0m2k 187 38 omitted omit VBN cord-015922-5wwy0m2k 187 39 . . . cord-015922-5wwy0m2k 188 1 HHV-6 HHV-6 NNP cord-015922-5wwy0m2k 188 2 is be VBZ cord-015922-5wwy0m2k 188 3 a a DT cord-015922-5wwy0m2k 188 4 β β NN cord-015922-5wwy0m2k 188 5 - - HYPH cord-015922-5wwy0m2k 188 6 herpesvirus herpesvirus NN cord-015922-5wwy0m2k 188 7 ( ( -LRB- cord-015922-5wwy0m2k 188 8 as as IN cord-015922-5wwy0m2k 188 9 is be VBZ cord-015922-5wwy0m2k 188 10 CMV CMV NNP cord-015922-5wwy0m2k 188 11 ) ) -RRB- cord-015922-5wwy0m2k 188 12 whose whose WP$ cord-015922-5wwy0m2k 188 13 role role NN cord-015922-5wwy0m2k 188 14 in in IN cord-015922-5wwy0m2k 188 15 post post JJ cord-015922-5wwy0m2k 188 16 - - JJ cord-015922-5wwy0m2k 188 17 transplant transplant JJ cord-015922-5wwy0m2k 188 18 complications complication NNS cord-015922-5wwy0m2k 188 19 is be VBZ cord-015922-5wwy0m2k 188 20 being be VBG cord-015922-5wwy0m2k 188 21 defined define VBN cord-015922-5wwy0m2k 188 22 . . . cord-015922-5wwy0m2k 189 1 In in IN cord-015922-5wwy0m2k 189 2 the the DT cord-015922-5wwy0m2k 189 3 great great JJ cord-015922-5wwy0m2k 189 4 majority majority NN cord-015922-5wwy0m2k 189 5 of of IN cord-015922-5wwy0m2k 189 6 instances instance NNS cord-015922-5wwy0m2k 189 7 , , , cord-015922-5wwy0m2k 189 8 HHV-6 HHV-6 NNP cord-015922-5wwy0m2k 189 9 primary primary JJ cord-015922-5wwy0m2k 189 10 infection infection NN cord-015922-5wwy0m2k 189 11 occurs occur VBZ cord-015922-5wwy0m2k 189 12 by by IN cord-015922-5wwy0m2k 189 13 the the DT cord-015922-5wwy0m2k 189 14 third third JJ cord-015922-5wwy0m2k 189 15 year year NN cord-015922-5wwy0m2k 189 16 of of IN cord-015922-5wwy0m2k 189 17 life life NN cord-015922-5wwy0m2k 189 18 , , , cord-015922-5wwy0m2k 189 19 with with IN cord-015922-5wwy0m2k 189 20 a a DT cord-015922-5wwy0m2k 189 21 seroprevalence seroprevalence NN cord-015922-5wwy0m2k 189 22 rate rate NN cord-015922-5wwy0m2k 189 23 of of IN cord-015922-5wwy0m2k 189 24 90 90 CD cord-015922-5wwy0m2k 189 25 percent percent NN cord-015922-5wwy0m2k 189 26 at at IN cord-015922-5wwy0m2k 189 27 one one CD cord-015922-5wwy0m2k 189 28 year year NN cord-015922-5wwy0m2k 189 29 , , , cord-015922-5wwy0m2k 189 30 and and CC cord-015922-5wwy0m2k 189 31 close close RB cord-015922-5wwy0m2k 189 32 to to TO cord-015922-5wwy0m2k 189 33 100 100 CD cord-015922-5wwy0m2k 189 34 percent percent NN cord-015922-5wwy0m2k 189 35 at at IN cord-015922-5wwy0m2k 189 36 three three CD cord-015922-5wwy0m2k 189 37 years year NNS cord-015922-5wwy0m2k 189 38 [ [ -LRB- cord-015922-5wwy0m2k 189 39 49 49 CD cord-015922-5wwy0m2k 189 40 , , , cord-015922-5wwy0m2k 189 41 50 50 CD cord-015922-5wwy0m2k 189 42 ] ] -RRB- cord-015922-5wwy0m2k 189 43 . . . cord-015922-5wwy0m2k 190 1 The the DT cord-015922-5wwy0m2k 190 2 clinical clinical JJ cord-015922-5wwy0m2k 190 3 effects effect NNS cord-015922-5wwy0m2k 190 4 associated associate VBN cord-015922-5wwy0m2k 190 5 with with IN cord-015922-5wwy0m2k 190 6 primary primary JJ cord-015922-5wwy0m2k 190 7 HHV-6 HHV-6 NNP cord-015922-5wwy0m2k 190 8 infection infection NN cord-015922-5wwy0m2k 190 9 include include VBP cord-015922-5wwy0m2k 190 10 exanthem exanthem NNP cord-015922-5wwy0m2k 190 11 subitum subitum NNP cord-015922-5wwy0m2k 190 12 ( ( -LRB- cord-015922-5wwy0m2k 190 13 roseola roseola NNP cord-015922-5wwy0m2k 190 14 ) ) -RRB- cord-015922-5wwy0m2k 190 15 , , , cord-015922-5wwy0m2k 190 16 and and CC cord-015922-5wwy0m2k 190 17 a a DT cord-015922-5wwy0m2k 190 18 form form NN cord-015922-5wwy0m2k 190 19 of of IN cord-015922-5wwy0m2k 190 20 encephalitis encephalitis NN cord-015922-5wwy0m2k 190 21 . . . cord-015922-5wwy0m2k 191 1 In in IN cord-015922-5wwy0m2k 191 2 HSCT HSCT NNP cord-015922-5wwy0m2k 191 3 patients patient NNS cord-015922-5wwy0m2k 191 4 , , , cord-015922-5wwy0m2k 191 5 bone bone NN cord-015922-5wwy0m2k 191 6 marrow marrow NN cord-015922-5wwy0m2k 191 7 suppression suppression NN cord-015922-5wwy0m2k 191 8 , , , cord-015922-5wwy0m2k 191 9 especially especially RB cord-015922-5wwy0m2k 191 10 delayed delay VBN cord-015922-5wwy0m2k 191 11 platelet platelet NN cord-015922-5wwy0m2k 191 12 engraftment engraftment NN cord-015922-5wwy0m2k 191 13 , , , cord-015922-5wwy0m2k 191 14 and and CC cord-015922-5wwy0m2k 191 15 encephalitis encephalitis RB cord-015922-5wwy0m2k 191 16 have have VBP cord-015922-5wwy0m2k 191 17 been be VBN cord-015922-5wwy0m2k 191 18 associated associate VBN cord-015922-5wwy0m2k 191 19 with with IN cord-015922-5wwy0m2k 191 20 HHV-6 HHV-6 NNP cord-015922-5wwy0m2k 191 21 type type NN cord-015922-5wwy0m2k 192 1 B. B. NNP cord-015922-5wwy0m2k 193 1 The the DT cord-015922-5wwy0m2k 193 2 encephalitis encephalitis RB cord-015922-5wwy0m2k 193 3 typically typically RB cord-015922-5wwy0m2k 193 4 occurs occur VBZ cord-015922-5wwy0m2k 193 5 one one CD cord-015922-5wwy0m2k 193 6 to to TO cord-015922-5wwy0m2k 193 7 two two CD cord-015922-5wwy0m2k 193 8 months month NNS cord-015922-5wwy0m2k 193 9 after after IN cord-015922-5wwy0m2k 193 10 transplantation transplantation NN cord-015922-5wwy0m2k 193 11 and and CC cord-015922-5wwy0m2k 193 12 is be VBZ cord-015922-5wwy0m2k 193 13 associated associate VBN cord-015922-5wwy0m2k 193 14 with with IN cord-015922-5wwy0m2k 193 15 profound profound JJ cord-015922-5wwy0m2k 193 16 memory memory NN cord-015922-5wwy0m2k 193 17 loss loss NN cord-015922-5wwy0m2k 193 18 , , , cord-015922-5wwy0m2k 193 19 especially especially RB cord-015922-5wwy0m2k 193 20 short short JJ cord-015922-5wwy0m2k 193 21 - - HYPH cord-015922-5wwy0m2k 193 22 term term NN cord-015922-5wwy0m2k 193 23 memory memory NN cord-015922-5wwy0m2k 193 24 , , , cord-015922-5wwy0m2k 193 25 and and CC cord-015922-5wwy0m2k 193 26 MRI MRI NNP cord-015922-5wwy0m2k 193 27 changes change NNS cord-015922-5wwy0m2k 193 28 in in IN cord-015922-5wwy0m2k 193 29 the the DT cord-015922-5wwy0m2k 193 30 mesial mesial JJ cord-015922-5wwy0m2k 193 31 temporal temporal JJ cord-015922-5wwy0m2k 193 32 lobes lobe NNS cord-015922-5wwy0m2k 193 33 ( ( -LRB- cord-015922-5wwy0m2k 193 34 limbic limbic JJ cord-015922-5wwy0m2k 193 35 encephalitis encephalitis RB cord-015922-5wwy0m2k 193 36 ) ) -RRB- cord-015922-5wwy0m2k 193 37 [ [ -LRB- cord-015922-5wwy0m2k 193 38 51 51 CD cord-015922-5wwy0m2k 193 39 , , , cord-015922-5wwy0m2k 193 40 52 52 CD cord-015922-5wwy0m2k 193 41 ] ] -RRB- cord-015922-5wwy0m2k 193 42 . . . cord-015922-5wwy0m2k 194 1 The the DT cord-015922-5wwy0m2k 194 2 highest high JJS cord-015922-5wwy0m2k 194 3 risk risk NN cord-015922-5wwy0m2k 194 4 patients patient NNS cord-015922-5wwy0m2k 194 5 for for IN cord-015922-5wwy0m2k 194 6 this this DT cord-015922-5wwy0m2k 194 7 complication complication NN cord-015922-5wwy0m2k 194 8 are be VBP cord-015922-5wwy0m2k 194 9 male male JJ cord-015922-5wwy0m2k 194 10 , , , cord-015922-5wwy0m2k 194 11 umbilical umbilical JJ cord-015922-5wwy0m2k 194 12 cord cord NN cord-015922-5wwy0m2k 194 13 blood blood NN cord-015922-5wwy0m2k 194 14 recipients recipient NNS cord-015922-5wwy0m2k 194 15 for for IN cord-015922-5wwy0m2k 194 16 whom whom WP cord-015922-5wwy0m2k 194 17 the the DT cord-015922-5wwy0m2k 194 18 attack attack NN cord-015922-5wwy0m2k 194 19 rate rate NN cord-015922-5wwy0m2k 194 20 may may MD cord-015922-5wwy0m2k 194 21 be be VB cord-015922-5wwy0m2k 194 22 as as RB cord-015922-5wwy0m2k 194 23 high high JJ cord-015922-5wwy0m2k 194 24 as as IN cord-015922-5wwy0m2k 194 25 10 10 CD cord-015922-5wwy0m2k 194 26 to to TO cord-015922-5wwy0m2k 194 27 20 20 CD cord-015922-5wwy0m2k 194 28 percent percent NN cord-015922-5wwy0m2k 194 29 . . . cord-015922-5wwy0m2k 195 1 Detecting detect VBG cord-015922-5wwy0m2k 195 2 HHV-6 HHV-6 NNP cord-015922-5wwy0m2k 195 3 DNA dna NN cord-015922-5wwy0m2k 195 4 in in IN cord-015922-5wwy0m2k 195 5 the the DT cord-015922-5wwy0m2k 195 6 blood blood NN cord-015922-5wwy0m2k 195 7 of of IN cord-015922-5wwy0m2k 195 8 allogeneic allogeneic VBG cord-015922-5wwy0m2k 195 9 HSCT HSCT NNP cord-015922-5wwy0m2k 195 10 recipients recipient NNS cord-015922-5wwy0m2k 195 11 is be VBZ cord-015922-5wwy0m2k 195 12 a a DT cord-015922-5wwy0m2k 195 13 common common JJ cord-015922-5wwy0m2k 195 14 phenomenon phenomenon NN cord-015922-5wwy0m2k 195 15 occurring occur VBG cord-015922-5wwy0m2k 195 16 transiently transiently RB cord-015922-5wwy0m2k 195 17 in in IN cord-015922-5wwy0m2k 195 18 40 40 CD cord-015922-5wwy0m2k 195 19 to to TO cord-015922-5wwy0m2k 195 20 60 60 CD cord-015922-5wwy0m2k 195 21 percent percent NN cord-015922-5wwy0m2k 195 22 of of IN cord-015922-5wwy0m2k 195 23 patients patient NNS cord-015922-5wwy0m2k 195 24 , , , cord-015922-5wwy0m2k 195 25 yet yet CC cord-015922-5wwy0m2k 195 26 encephalitis encephalitis JJ cord-015922-5wwy0m2k 195 27 is be VBZ cord-015922-5wwy0m2k 195 28 a a DT cord-015922-5wwy0m2k 195 29 rather rather RB cord-015922-5wwy0m2k 195 30 infrequent infrequent JJ cord-015922-5wwy0m2k 195 31 occurrence occurrence NN cord-015922-5wwy0m2k 195 32 ( ( -LRB- cord-015922-5wwy0m2k 195 33 1 1 CD cord-015922-5wwy0m2k 195 34 - - SYM cord-015922-5wwy0m2k 195 35 2 2 CD cord-015922-5wwy0m2k 195 36 % % NN cord-015922-5wwy0m2k 195 37 ) ) -RRB- cord-015922-5wwy0m2k 195 38 . . . cord-015922-5wwy0m2k 196 1 As as IN cord-015922-5wwy0m2k 196 2 obtaining obtain VBG cord-015922-5wwy0m2k 196 3 brain brain NN cord-015922-5wwy0m2k 196 4 biopsies biopsy NNS cord-015922-5wwy0m2k 196 5 is be VBZ cord-015922-5wwy0m2k 196 6 not not RB cord-015922-5wwy0m2k 196 7 usually usually RB cord-015922-5wwy0m2k 196 8 feasible feasible JJ cord-015922-5wwy0m2k 196 9 early early RB cord-015922-5wwy0m2k 196 10 after after IN cord-015922-5wwy0m2k 196 11 transplantation transplantation NN cord-015922-5wwy0m2k 196 12 , , , cord-015922-5wwy0m2k 196 13 the the DT cord-015922-5wwy0m2k 196 14 diagnosis diagnosis NN cord-015922-5wwy0m2k 196 15 of of IN cord-015922-5wwy0m2k 196 16 HHV-6 HHV-6 NNP cord-015922-5wwy0m2k 196 17 encephalitis encephalitis RB cord-015922-5wwy0m2k 196 18 is be VBZ cord-015922-5wwy0m2k 196 19 currently currently RB cord-015922-5wwy0m2k 196 20 achieved achieve VBN cord-015922-5wwy0m2k 196 21 by by IN cord-015922-5wwy0m2k 196 22 developing develop VBG cord-015922-5wwy0m2k 196 23 an an DT cord-015922-5wwy0m2k 196 24 acute acute JJ cord-015922-5wwy0m2k 196 25 limbic limbic NNP cord-015922-5wwy0m2k 196 26 encephalitis encephalitis NNP cord-015922-5wwy0m2k 196 27 syndrome syndrome NN cord-015922-5wwy0m2k 196 28 , , , cord-015922-5wwy0m2k 196 29 confirmed confirm VBD cord-015922-5wwy0m2k 196 30 with with IN cord-015922-5wwy0m2k 196 31 MRI MRI NNP cord-015922-5wwy0m2k 196 32 imaging imaging NN cord-015922-5wwy0m2k 196 33 of of IN cord-015922-5wwy0m2k 196 34 the the DT cord-015922-5wwy0m2k 196 35 brain brain NN cord-015922-5wwy0m2k 196 36 and and CC cord-015922-5wwy0m2k 196 37 by by IN cord-015922-5wwy0m2k 196 38 the the DT cord-015922-5wwy0m2k 196 39 detection detection NN cord-015922-5wwy0m2k 196 40 of of IN cord-015922-5wwy0m2k 196 41 HHV-6 HHV-6 NNP cord-015922-5wwy0m2k 196 42 in in IN cord-015922-5wwy0m2k 196 43 the the DT cord-015922-5wwy0m2k 196 44 CSF CSF NNP cord-015922-5wwy0m2k 196 45 [ [ -LRB- cord-015922-5wwy0m2k 196 46 52 52 CD cord-015922-5wwy0m2k 196 47 ] ] -RRB- cord-015922-5wwy0m2k 196 48 . . . cord-015922-5wwy0m2k 197 1 It -PRON- PRP cord-015922-5wwy0m2k 197 2 remains remain VBZ cord-015922-5wwy0m2k 197 3 unclear unclear JJ cord-015922-5wwy0m2k 197 4 what what WP cord-015922-5wwy0m2k 197 5 the the DT cord-015922-5wwy0m2k 197 6 treatment treatment NN cord-015922-5wwy0m2k 197 7 of of IN cord-015922-5wwy0m2k 197 8 choice choice NN cord-015922-5wwy0m2k 197 9 for for IN cord-015922-5wwy0m2k 197 10 this this DT cord-015922-5wwy0m2k 197 11 virus virus NN cord-015922-5wwy0m2k 197 12 is be VBZ cord-015922-5wwy0m2k 197 13 . . . cord-015922-5wwy0m2k 198 1 One one CD cord-015922-5wwy0m2k 198 2 approach approach NN cord-015922-5wwy0m2k 198 3 that that IN cord-015922-5wwy0m2k 198 4 we -PRON- PRP cord-015922-5wwy0m2k 198 5 currently currently RB cord-015922-5wwy0m2k 198 6 favor favor VBP cord-015922-5wwy0m2k 198 7 is be VBZ cord-015922-5wwy0m2k 198 8 to to TO cord-015922-5wwy0m2k 198 9 use use VB cord-015922-5wwy0m2k 198 10 foscarnet foscarnet NN cord-015922-5wwy0m2k 198 11 . . . cord-015922-5wwy0m2k 199 1 It -PRON- PRP cord-015922-5wwy0m2k 199 2 is be VBZ cord-015922-5wwy0m2k 199 3 possible possible JJ cord-015922-5wwy0m2k 199 4 that that IN cord-015922-5wwy0m2k 199 5 anti anti JJ cord-015922-5wwy0m2k 199 6 - - JJ cord-015922-5wwy0m2k 199 7 CMV cmv JJ cord-015922-5wwy0m2k 199 8 preventative preventative JJ cord-015922-5wwy0m2k 199 9 strategies strategy NNS cord-015922-5wwy0m2k 199 10 with with IN cord-015922-5wwy0m2k 199 11 ganciclovir ganciclovir NNS cord-015922-5wwy0m2k 199 12 may may MD cord-015922-5wwy0m2k 199 13 have have VB cord-015922-5wwy0m2k 199 14 a a DT cord-015922-5wwy0m2k 199 15 beneficial beneficial JJ cord-015922-5wwy0m2k 199 16 effect effect NN cord-015922-5wwy0m2k 199 17 on on IN cord-015922-5wwy0m2k 199 18 this this DT cord-015922-5wwy0m2k 199 19 virus virus NN cord-015922-5wwy0m2k 199 20 as as RB cord-015922-5wwy0m2k 199 21 well well RB cord-015922-5wwy0m2k 199 22 [ [ -LRB- cord-015922-5wwy0m2k 199 23 1 1 CD cord-015922-5wwy0m2k 199 24 , , , cord-015922-5wwy0m2k 199 25 53 53 CD cord-015922-5wwy0m2k 199 26 ] ] -RRB- cord-015922-5wwy0m2k 199 27 . . . cord-015922-5wwy0m2k 200 1 HSCT HSCT NNP cord-015922-5wwy0m2k 200 2 recipients recipient NNS cord-015922-5wwy0m2k 200 3 are be VBP cord-015922-5wwy0m2k 200 4 at at IN cord-015922-5wwy0m2k 200 5 significant significant JJ cord-015922-5wwy0m2k 200 6 risk risk NN cord-015922-5wwy0m2k 200 7 for for IN cord-015922-5wwy0m2k 200 8 infection infection NN cord-015922-5wwy0m2k 200 9 with with IN cord-015922-5wwy0m2k 200 10 respiratory respiratory JJ cord-015922-5wwy0m2k 200 11 viruses virus NNS cord-015922-5wwy0m2k 200 12 circulating circulate VBG cord-015922-5wwy0m2k 200 13 in in IN cord-015922-5wwy0m2k 200 14 the the DT cord-015922-5wwy0m2k 200 15 community community NN cord-015922-5wwy0m2k 200 16 . . . cord-015922-5wwy0m2k 201 1 These these DT cord-015922-5wwy0m2k 201 2 infections infection NNS cord-015922-5wwy0m2k 201 3 can can MD cord-015922-5wwy0m2k 201 4 occur occur VB cord-015922-5wwy0m2k 201 5 at at IN cord-015922-5wwy0m2k 201 6 any any DT cord-015922-5wwy0m2k 201 7 time time NN cord-015922-5wwy0m2k 201 8 in in IN cord-015922-5wwy0m2k 201 9 the the DT cord-015922-5wwy0m2k 201 10 post post JJ cord-015922-5wwy0m2k 201 11 - - JJ cord-015922-5wwy0m2k 201 12 transplant transplant JJ cord-015922-5wwy0m2k 201 13 course course NN cord-015922-5wwy0m2k 201 14 , , , cord-015922-5wwy0m2k 201 15 and and CC cord-015922-5wwy0m2k 201 16 can can MD cord-015922-5wwy0m2k 201 17 be be VB cord-015922-5wwy0m2k 201 18 acquired acquire VBN cord-015922-5wwy0m2k 201 19 in in IN cord-015922-5wwy0m2k 201 20 the the DT cord-015922-5wwy0m2k 201 21 community community NN cord-015922-5wwy0m2k 201 22 or or CC cord-015922-5wwy0m2k 201 23 during during IN cord-015922-5wwy0m2k 201 24 hospitalization hospitalization NN cord-015922-5wwy0m2k 201 25 from from IN cord-015922-5wwy0m2k 201 26 infected infected JJ cord-015922-5wwy0m2k 201 27 staff staff NN cord-015922-5wwy0m2k 201 28 , , , cord-015922-5wwy0m2k 201 29 family family NN cord-015922-5wwy0m2k 201 30 and and CC cord-015922-5wwy0m2k 201 31 friends friend NNS cord-015922-5wwy0m2k 201 32 . . . cord-015922-5wwy0m2k 202 1 Overall overall RB cord-015922-5wwy0m2k 202 2 , , , cord-015922-5wwy0m2k 202 3 an an DT cord-015922-5wwy0m2k 202 4 estimated estimate VBN cord-015922-5wwy0m2k 202 5 10 10 CD cord-015922-5wwy0m2k 202 6 to to TO cord-015922-5wwy0m2k 202 7 20 20 CD cord-015922-5wwy0m2k 202 8 percent percent NN cord-015922-5wwy0m2k 202 9 of of IN cord-015922-5wwy0m2k 202 10 HSCT HSCT NNP cord-015922-5wwy0m2k 202 11 patients patient NNS cord-015922-5wwy0m2k 202 12 will will MD cord-015922-5wwy0m2k 202 13 become become VB cord-015922-5wwy0m2k 202 14 infected infect VBN cord-015922-5wwy0m2k 202 15 in in IN cord-015922-5wwy0m2k 202 16 the the DT cord-015922-5wwy0m2k 202 17 first first JJ cord-015922-5wwy0m2k 202 18 year year NN cord-015922-5wwy0m2k 202 19 posttransplant posttransplant NN cord-015922-5wwy0m2k 202 20 , , , cord-015922-5wwy0m2k 202 21 with with IN cord-015922-5wwy0m2k 202 22 the the DT cord-015922-5wwy0m2k 202 23 potential potential NN cord-015922-5wwy0m2k 202 24 for for IN cord-015922-5wwy0m2k 202 25 this this DT cord-015922-5wwy0m2k 202 26 figure figure NN cord-015922-5wwy0m2k 202 27 to to TO cord-015922-5wwy0m2k 202 28 rise rise VB cord-015922-5wwy0m2k 202 29 significantly significantly RB cord-015922-5wwy0m2k 202 30 in in IN cord-015922-5wwy0m2k 202 31 the the DT cord-015922-5wwy0m2k 202 32 setting setting NN cord-015922-5wwy0m2k 202 33 of of IN cord-015922-5wwy0m2k 202 34 a a DT cord-015922-5wwy0m2k 202 35 community community NN cord-015922-5wwy0m2k 202 36 - - HYPH cord-015922-5wwy0m2k 202 37 wide wide JJ cord-015922-5wwy0m2k 202 38 outbreak outbreak NN cord-015922-5wwy0m2k 202 39 [ [ -LRB- cord-015922-5wwy0m2k 202 40 54 54 CD cord-015922-5wwy0m2k 202 41 ] ] -RRB- cord-015922-5wwy0m2k 202 42 . . . cord-015922-5wwy0m2k 203 1 The the DT cord-015922-5wwy0m2k 203 2 dilemma dilemma NN cord-015922-5wwy0m2k 203 3 for for IN cord-015922-5wwy0m2k 203 4 the the DT cord-015922-5wwy0m2k 203 5 clinician clinician NN cord-015922-5wwy0m2k 203 6 is be VBZ cord-015922-5wwy0m2k 203 7 how how WRB cord-015922-5wwy0m2k 203 8 to to TO cord-015922-5wwy0m2k 203 9 prevent prevent VB cord-015922-5wwy0m2k 203 10 these these DT cord-015922-5wwy0m2k 203 11 infections infection NNS cord-015922-5wwy0m2k 203 12 , , , cord-015922-5wwy0m2k 203 13 as as IN cord-015922-5wwy0m2k 203 14 there there EX cord-015922-5wwy0m2k 203 15 is be VBZ cord-015922-5wwy0m2k 203 16 a a DT cord-015922-5wwy0m2k 203 17 far far RB cord-015922-5wwy0m2k 203 18 higher high JJR cord-015922-5wwy0m2k 203 19 rate rate NN cord-015922-5wwy0m2k 203 20 of of IN cord-015922-5wwy0m2k 203 21 progression progression NN cord-015922-5wwy0m2k 203 22 to to IN cord-015922-5wwy0m2k 203 23 pneumonia pneumonia NN cord-015922-5wwy0m2k 203 24 ( ( -LRB- cord-015922-5wwy0m2k 203 25 viral viral JJ cord-015922-5wwy0m2k 203 26 and/or and/or CC cord-015922-5wwy0m2k 203 27 bacterial bacterial JJ cord-015922-5wwy0m2k 203 28 or or CC cord-015922-5wwy0m2k 203 29 fungal fungal JJ cord-015922-5wwy0m2k 203 30 superinfection superinfection NN cord-015922-5wwy0m2k 203 31 ) ) -RRB- cord-015922-5wwy0m2k 203 32 , , , cord-015922-5wwy0m2k 203 33 which which WDT cord-015922-5wwy0m2k 203 34 carries carry VBZ cord-015922-5wwy0m2k 203 35 a a DT cord-015922-5wwy0m2k 203 36 far far RB cord-015922-5wwy0m2k 203 37 higher high JJR cord-015922-5wwy0m2k 203 38 morbidity morbidity NN cord-015922-5wwy0m2k 203 39 and and CC cord-015922-5wwy0m2k 203 40 mortality mortality NN cord-015922-5wwy0m2k 203 41 than than IN cord-015922-5wwy0m2k 203 42 what what WP cord-015922-5wwy0m2k 203 43 is be VBZ cord-015922-5wwy0m2k 203 44 observed observe VBN cord-015922-5wwy0m2k 203 45 in in IN cord-015922-5wwy0m2k 203 46 the the DT cord-015922-5wwy0m2k 203 47 general general JJ cord-015922-5wwy0m2k 203 48 population population NN cord-015922-5wwy0m2k 203 49 . . . cord-015922-5wwy0m2k 204 1 In in IN cord-015922-5wwy0m2k 204 2 addition addition NN cord-015922-5wwy0m2k 204 3 , , , cord-015922-5wwy0m2k 204 4 antiviral antiviral JJ cord-015922-5wwy0m2k 204 5 therapy therapy NN cord-015922-5wwy0m2k 204 6 for for IN cord-015922-5wwy0m2k 204 7 these these DT cord-015922-5wwy0m2k 204 8 agents agent NNS cord-015922-5wwy0m2k 204 9 is be VBZ cord-015922-5wwy0m2k 204 10 in in IN cord-015922-5wwy0m2k 204 11 its -PRON- PRP$ cord-015922-5wwy0m2k 204 12 infancy infancy NN cord-015922-5wwy0m2k 204 13 . . . cord-015922-5wwy0m2k 205 1 It -PRON- PRP cord-015922-5wwy0m2k 205 2 is be VBZ cord-015922-5wwy0m2k 205 3 important important JJ cord-015922-5wwy0m2k 205 4 to to TO cord-015922-5wwy0m2k 205 5 attempt attempt VB cord-015922-5wwy0m2k 205 6 to to TO cord-015922-5wwy0m2k 205 7 make make VB cord-015922-5wwy0m2k 205 8 an an DT cord-015922-5wwy0m2k 205 9 etiologic etiologic JJ cord-015922-5wwy0m2k 205 10 diagnosis diagnosis NN cord-015922-5wwy0m2k 205 11 . . . cord-015922-5wwy0m2k 206 1 Avoiding avoid VBG cord-015922-5wwy0m2k 206 2 exposure exposure NN cord-015922-5wwy0m2k 206 3 to to IN cord-015922-5wwy0m2k 206 4 infected infected JJ cord-015922-5wwy0m2k 206 5 individuals individual NNS cord-015922-5wwy0m2k 206 6 by by IN cord-015922-5wwy0m2k 206 7 systematic systematic JJ cord-015922-5wwy0m2k 206 8 infection infection NN cord-015922-5wwy0m2k 206 9 control control NN cord-015922-5wwy0m2k 206 10 measures measure NNS cord-015922-5wwy0m2k 206 11 in in IN cord-015922-5wwy0m2k 206 12 both both DT cord-015922-5wwy0m2k 206 13 family family NN cord-015922-5wwy0m2k 206 14 members member NNS cord-015922-5wwy0m2k 206 15 and and CC cord-015922-5wwy0m2k 206 16 friends friend NNS cord-015922-5wwy0m2k 206 17 , , , cord-015922-5wwy0m2k 206 18 but but CC cord-015922-5wwy0m2k 206 19 most most RBS cord-015922-5wwy0m2k 206 20 importantly importantly RB cord-015922-5wwy0m2k 206 21 in in IN cord-015922-5wwy0m2k 206 22 health health NN cord-015922-5wwy0m2k 206 23 care care NN cord-015922-5wwy0m2k 206 24 workers worker NNS cord-015922-5wwy0m2k 206 25 , , , cord-015922-5wwy0m2k 206 26 is be VBZ cord-015922-5wwy0m2k 206 27 the the DT cord-015922-5wwy0m2k 206 28 best good JJS cord-015922-5wwy0m2k 206 29 preventative preventative JJ cord-015922-5wwy0m2k 206 30 strategy strategy NN cord-015922-5wwy0m2k 206 31 available available JJ cord-015922-5wwy0m2k 206 32 [ [ -LRB- cord-015922-5wwy0m2k 206 33 55 55 CD cord-015922-5wwy0m2k 206 34 ] ] -RRB- cord-015922-5wwy0m2k 206 35 [ [ -LRB- cord-015922-5wwy0m2k 206 36 56 56 CD cord-015922-5wwy0m2k 206 37 ] ] -RRB- cord-015922-5wwy0m2k 206 38 [ [ -LRB- cord-015922-5wwy0m2k 206 39 57 57 CD cord-015922-5wwy0m2k 206 40 ] ] -RRB- cord-015922-5wwy0m2k 206 41 [ [ -LRB- cord-015922-5wwy0m2k 206 42 58 58 CD cord-015922-5wwy0m2k 206 43 ] ] -RRB- cord-015922-5wwy0m2k 206 44 . . . cord-015922-5wwy0m2k 207 1 Although although IN cord-015922-5wwy0m2k 207 2 RSV RSV NNP cord-015922-5wwy0m2k 207 3 can can MD cord-015922-5wwy0m2k 207 4 be be VB cord-015922-5wwy0m2k 207 5 acquired acquire VBN cord-015922-5wwy0m2k 207 6 by by IN cord-015922-5wwy0m2k 207 7 inhaling inhale VBG cord-015922-5wwy0m2k 207 8 an an DT cord-015922-5wwy0m2k 207 9 aerosol aerosol NN cord-015922-5wwy0m2k 207 10 , , , cord-015922-5wwy0m2k 207 11 direct direct JJ cord-015922-5wwy0m2k 207 12 contact contact NN cord-015922-5wwy0m2k 207 13 with with IN cord-015922-5wwy0m2k 207 14 infected infected JJ cord-015922-5wwy0m2k 207 15 secretions secretion NNS cord-015922-5wwy0m2k 207 16 is be VBZ cord-015922-5wwy0m2k 207 17 the the DT cord-015922-5wwy0m2k 207 18 usual usual JJ cord-015922-5wwy0m2k 207 19 mode mode NN cord-015922-5wwy0m2k 207 20 of of IN cord-015922-5wwy0m2k 207 21 spread spread NN cord-015922-5wwy0m2k 207 22 between between IN cord-015922-5wwy0m2k 207 23 individuals individual NNS cord-015922-5wwy0m2k 207 24 . . . cord-015922-5wwy0m2k 208 1 In in IN cord-015922-5wwy0m2k 208 2 the the DT cord-015922-5wwy0m2k 208 3 HSCT HSCT NNP cord-015922-5wwy0m2k 208 4 patient patient NN cord-015922-5wwy0m2k 208 5 , , , cord-015922-5wwy0m2k 208 6 both both DT cord-015922-5wwy0m2k 208 7 adult adult NN cord-015922-5wwy0m2k 208 8 and and CC cord-015922-5wwy0m2k 208 9 pediatric pediatric JJ cord-015922-5wwy0m2k 208 10 , , , cord-015922-5wwy0m2k 208 11 RSV RSV NNP cord-015922-5wwy0m2k 208 12 is be VBZ cord-015922-5wwy0m2k 208 13 a a DT cord-015922-5wwy0m2k 208 14 cause cause NN cord-015922-5wwy0m2k 208 15 of of IN cord-015922-5wwy0m2k 208 16 significant significant JJ cord-015922-5wwy0m2k 208 17 morbidity morbidity NN cord-015922-5wwy0m2k 208 18 and and CC cord-015922-5wwy0m2k 208 19 mortality mortality NN cord-015922-5wwy0m2k 208 20 . . . cord-015922-5wwy0m2k 209 1 The the DT cord-015922-5wwy0m2k 209 2 illness illness NN cord-015922-5wwy0m2k 209 3 begins begin VBZ cord-015922-5wwy0m2k 209 4 with with IN cord-015922-5wwy0m2k 209 5 the the DT cord-015922-5wwy0m2k 209 6 signs sign NNS cord-015922-5wwy0m2k 209 7 and and CC cord-015922-5wwy0m2k 209 8 symptoms symptom NNS cord-015922-5wwy0m2k 209 9 of of IN cord-015922-5wwy0m2k 209 10 a a DT cord-015922-5wwy0m2k 209 11 viral viral JJ cord-015922-5wwy0m2k 209 12 upper upper JJ cord-015922-5wwy0m2k 209 13 respiratory respiratory JJ cord-015922-5wwy0m2k 209 14 tract tract NN cord-015922-5wwy0m2k 209 15 infection infection NN cord-015922-5wwy0m2k 209 16 ( ( -LRB- cord-015922-5wwy0m2k 209 17 rhinorrhea rhinorrhea NNP cord-015922-5wwy0m2k 209 18 , , , cord-015922-5wwy0m2k 209 19 sinus sinus NN cord-015922-5wwy0m2k 209 20 congestion congestion NN cord-015922-5wwy0m2k 209 21 , , , cord-015922-5wwy0m2k 209 22 sore sore JJ cord-015922-5wwy0m2k 209 23 throat throat NN cord-015922-5wwy0m2k 209 24 and/or and/or CC cord-015922-5wwy0m2k 209 25 otitis otitis NN cord-015922-5wwy0m2k 209 26 media medium NNS cord-015922-5wwy0m2k 209 27 ) ) -RRB- cord-015922-5wwy0m2k 209 28 , , , cord-015922-5wwy0m2k 209 29 that that WDT cord-015922-5wwy0m2k 209 30 may may MD cord-015922-5wwy0m2k 209 31 progress progress VB cord-015922-5wwy0m2k 209 32 to to IN cord-015922-5wwy0m2k 209 33 pneumonia pneumonia NN cord-015922-5wwy0m2k 209 34 , , , cord-015922-5wwy0m2k 209 35 especially especially RB cord-015922-5wwy0m2k 209 36 if if IN cord-015922-5wwy0m2k 209 37 the the DT cord-015922-5wwy0m2k 209 38 virus virus NN cord-015922-5wwy0m2k 209 39 is be VBZ cord-015922-5wwy0m2k 209 40 acquired acquire VBN cord-015922-5wwy0m2k 209 41 in in IN cord-015922-5wwy0m2k 209 42 the the DT cord-015922-5wwy0m2k 209 43 preengraftment preengraftment NN cord-015922-5wwy0m2k 209 44 phase phase NN cord-015922-5wwy0m2k 209 45 . . . cord-015922-5wwy0m2k 210 1 As as IN cord-015922-5wwy0m2k 210 2 with with IN cord-015922-5wwy0m2k 210 3 influenza influenza NN cord-015922-5wwy0m2k 210 4 , , , cord-015922-5wwy0m2k 210 5 pneumonic pneumonic JJ cord-015922-5wwy0m2k 210 6 syndromes syndrome NNS cord-015922-5wwy0m2k 210 7 can can MD cord-015922-5wwy0m2k 210 8 be be VB cord-015922-5wwy0m2k 210 9 due due JJ cord-015922-5wwy0m2k 210 10 to to IN cord-015922-5wwy0m2k 210 11 RSV RSV NNP cord-015922-5wwy0m2k 210 12 itself -PRON- PRP cord-015922-5wwy0m2k 210 13 , , , cord-015922-5wwy0m2k 210 14 but but CC cord-015922-5wwy0m2k 210 15 in in IN cord-015922-5wwy0m2k 210 16 our -PRON- PRP$ cord-015922-5wwy0m2k 210 17 experience experience NN cord-015922-5wwy0m2k 210 18 it -PRON- PRP cord-015922-5wwy0m2k 210 19 is be VBZ cord-015922-5wwy0m2k 210 20 more more RBR cord-015922-5wwy0m2k 210 21 frequently frequently RB cord-015922-5wwy0m2k 210 22 due due JJ cord-015922-5wwy0m2k 210 23 to to IN cord-015922-5wwy0m2k 210 24 secondary secondary JJ cord-015922-5wwy0m2k 210 25 bacterial bacterial NN cord-015922-5wwy0m2k 210 26 and and CC cord-015922-5wwy0m2k 210 27 fungal fungal JJ cord-015922-5wwy0m2k 210 28 infections infection NNS cord-015922-5wwy0m2k 210 29 . . . cord-015922-5wwy0m2k 211 1 The the DT cord-015922-5wwy0m2k 211 2 advent advent NN cord-015922-5wwy0m2k 211 3 of of IN cord-015922-5wwy0m2k 211 4 rapid rapid JJ cord-015922-5wwy0m2k 211 5 RSV RSV NNP cord-015922-5wwy0m2k 211 6 diagnosis diagnosis NN cord-015922-5wwy0m2k 211 7 by by IN cord-015922-5wwy0m2k 211 8 antigen antigen NN cord-015922-5wwy0m2k 211 9 detection detection NN cord-015922-5wwy0m2k 211 10 in in IN cord-015922-5wwy0m2k 211 11 nasopharyngeal nasopharyngeal JJ cord-015922-5wwy0m2k 211 12 swabs swab NNS cord-015922-5wwy0m2k 211 13 has have VBZ cord-015922-5wwy0m2k 211 14 resulted result VBN cord-015922-5wwy0m2k 211 15 in in IN cord-015922-5wwy0m2k 211 16 the the DT cord-015922-5wwy0m2k 211 17 recognition recognition NN cord-015922-5wwy0m2k 211 18 that that IN cord-015922-5wwy0m2k 211 19 RSV RSV NNP cord-015922-5wwy0m2k 211 20 is be VBZ cord-015922-5wwy0m2k 211 21 a a DT cord-015922-5wwy0m2k 211 22 significant significant JJ cord-015922-5wwy0m2k 211 23 pathogen pathogen NN cord-015922-5wwy0m2k 211 24 for for IN cord-015922-5wwy0m2k 211 25 both both DT cord-015922-5wwy0m2k 211 26 adults adult NNS cord-015922-5wwy0m2k 211 27 and and CC cord-015922-5wwy0m2k 211 28 children child NNS cord-015922-5wwy0m2k 211 29 , , , cord-015922-5wwy0m2k 211 30 particularly particularly RB cord-015922-5wwy0m2k 211 31 in in IN cord-015922-5wwy0m2k 211 32 immunosuppressed immunosuppressed JJ cord-015922-5wwy0m2k 211 33 patients patient NNS cord-015922-5wwy0m2k 211 34 . . . cord-015922-5wwy0m2k 212 1 Optimal optimal JJ cord-015922-5wwy0m2k 212 2 antiviral antiviral JJ cord-015922-5wwy0m2k 212 3 management management NN cord-015922-5wwy0m2k 212 4 , , , cord-015922-5wwy0m2k 212 5 however however RB cord-015922-5wwy0m2k 212 6 , , , cord-015922-5wwy0m2k 212 7 remains remain VBZ cord-015922-5wwy0m2k 212 8 unclear unclear JJ cord-015922-5wwy0m2k 212 9 . . . cord-015922-5wwy0m2k 213 1 There there EX cord-015922-5wwy0m2k 213 2 are be VBP cord-015922-5wwy0m2k 213 3 reports report NNS cord-015922-5wwy0m2k 213 4 that that IN cord-015922-5wwy0m2k 213 5 aerosolized aerosolize VBN cord-015922-5wwy0m2k 213 6 ribavirin ribavirin RB cord-015922-5wwy0m2k 213 7 + + CC cord-015922-5wwy0m2k 213 8 /− /− . cord-015922-5wwy0m2k 213 9 anti anti JJ cord-015922-5wwy0m2k 213 10 - - JJ cord-015922-5wwy0m2k 213 11 RSV rsv JJ cord-015922-5wwy0m2k 213 12 polyclonal polyclonal JJ cord-015922-5wwy0m2k 213 13 or or CC cord-015922-5wwy0m2k 213 14 monoclonal monoclonal JJ cord-015922-5wwy0m2k 213 15 antibody antibody NN cord-015922-5wwy0m2k 213 16 may may MD cord-015922-5wwy0m2k 213 17 have have VB cord-015922-5wwy0m2k 213 18 therapeutic therapeutic JJ cord-015922-5wwy0m2k 213 19 benefit benefit NN cord-015922-5wwy0m2k 213 20 , , , cord-015922-5wwy0m2k 213 21 but but CC cord-015922-5wwy0m2k 213 22 this this DT cord-015922-5wwy0m2k 213 23 remains remain VBZ cord-015922-5wwy0m2k 213 24 unproven unproven JJ cord-015922-5wwy0m2k 213 25 . . . cord-015922-5wwy0m2k 214 1 There there EX cord-015922-5wwy0m2k 214 2 is be VBZ cord-015922-5wwy0m2k 214 3 also also RB cord-015922-5wwy0m2k 214 4 interest interest NN cord-015922-5wwy0m2k 214 5 in in IN cord-015922-5wwy0m2k 214 6 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 214 7 with with IN cord-015922-5wwy0m2k 214 8 an an DT cord-015922-5wwy0m2k 214 9 anti anti JJ cord-015922-5wwy0m2k 214 10 - - JJ cord-015922-5wwy0m2k 214 11 RSV rsv JJ cord-015922-5wwy0m2k 214 12 antibody antibody NN cord-015922-5wwy0m2k 214 13 , , , cord-015922-5wwy0m2k 214 14 although although IN cord-015922-5wwy0m2k 214 15 there there EX cord-015922-5wwy0m2k 214 16 have have VBP cord-015922-5wwy0m2k 214 17 been be VBN cord-015922-5wwy0m2k 214 18 no no DT cord-015922-5wwy0m2k 214 19 trials trial NNS cord-015922-5wwy0m2k 214 20 in in IN cord-015922-5wwy0m2k 214 21 HSCT HSCT NNP cord-015922-5wwy0m2k 214 22 patients patient NNS cord-015922-5wwy0m2k 214 23 [ [ -LRB- cord-015922-5wwy0m2k 214 24 55 55 CD cord-015922-5wwy0m2k 214 25 ] ] -RRB- cord-015922-5wwy0m2k 214 26 [ [ -LRB- cord-015922-5wwy0m2k 214 27 56 56 CD cord-015922-5wwy0m2k 214 28 ] ] -RRB- cord-015922-5wwy0m2k 214 29 [ [ -LRB- cord-015922-5wwy0m2k 214 30 57 57 CD cord-015922-5wwy0m2k 214 31 ] ] -RRB- cord-015922-5wwy0m2k 214 32 [ [ -LRB- cord-015922-5wwy0m2k 214 33 58 58 CD cord-015922-5wwy0m2k 214 34 ] ] -RRB- cord-015922-5wwy0m2k 214 35 [ [ -LRB- cord-015922-5wwy0m2k 214 36 59 59 CD cord-015922-5wwy0m2k 214 37 ] ] -RRB- cord-015922-5wwy0m2k 214 38 . . . cord-015922-5wwy0m2k 215 1 As as IN cord-015922-5wwy0m2k 215 2 with with IN cord-015922-5wwy0m2k 215 3 RSV RSV NNP cord-015922-5wwy0m2k 215 4 , , , cord-015922-5wwy0m2k 215 5 the the DT cord-015922-5wwy0m2k 215 6 incidence incidence NN cord-015922-5wwy0m2k 215 7 of of IN cord-015922-5wwy0m2k 215 8 influenza influenza NN cord-015922-5wwy0m2k 215 9 infection infection NN cord-015922-5wwy0m2k 215 10 in in IN cord-015922-5wwy0m2k 215 11 HSCT HSCT NNP cord-015922-5wwy0m2k 215 12 patients patient NNS cord-015922-5wwy0m2k 215 13 reflects reflect VBZ cord-015922-5wwy0m2k 215 14 the the DT cord-015922-5wwy0m2k 215 15 level level NN cord-015922-5wwy0m2k 215 16 of of IN cord-015922-5wwy0m2k 215 17 influenza influenza NN cord-015922-5wwy0m2k 215 18 activity activity NN cord-015922-5wwy0m2k 215 19 in in IN cord-015922-5wwy0m2k 215 20 the the DT cord-015922-5wwy0m2k 215 21 community community NN cord-015922-5wwy0m2k 215 22 . . . cord-015922-5wwy0m2k 216 1 The the DT cord-015922-5wwy0m2k 216 2 impact impact NN cord-015922-5wwy0m2k 216 3 of of IN cord-015922-5wwy0m2k 216 4 this this DT cord-015922-5wwy0m2k 216 5 virus virus NN cord-015922-5wwy0m2k 216 6 on on IN cord-015922-5wwy0m2k 216 7 infected infected JJ cord-015922-5wwy0m2k 216 8 HSCT HSCT NNP cord-015922-5wwy0m2k 216 9 recipients recipient NNS cord-015922-5wwy0m2k 216 10 is be VBZ cord-015922-5wwy0m2k 216 11 demonstrated demonstrate VBN cord-015922-5wwy0m2k 216 12 by by IN cord-015922-5wwy0m2k 216 13 the the DT cord-015922-5wwy0m2k 216 14 following follow VBG cord-015922-5wwy0m2k 216 15 statistics statistic NNS cord-015922-5wwy0m2k 216 16 : : : cord-015922-5wwy0m2k 216 17 ~60 ~60 CD cord-015922-5wwy0m2k 216 18 percent percent NN cord-015922-5wwy0m2k 216 19 of of IN cord-015922-5wwy0m2k 216 20 the the DT cord-015922-5wwy0m2k 216 21 patients patient NNS cord-015922-5wwy0m2k 216 22 with with IN cord-015922-5wwy0m2k 216 23 influenza influenza NN cord-015922-5wwy0m2k 216 24 develop develop VB cord-015922-5wwy0m2k 216 25 pneumonia pneumonia NN cord-015922-5wwy0m2k 216 26 and and CC cord-015922-5wwy0m2k 216 27 ~25 ~25 CD cord-015922-5wwy0m2k 216 28 percent percent NN cord-015922-5wwy0m2k 216 29 of of IN cord-015922-5wwy0m2k 216 30 patients patient NNS cord-015922-5wwy0m2k 216 31 with with IN cord-015922-5wwy0m2k 216 32 influenza influenza NN cord-015922-5wwy0m2k 216 33 pneumonia pneumonia NN cord-015922-5wwy0m2k 216 34 die die NN cord-015922-5wwy0m2k 216 35 of of IN cord-015922-5wwy0m2k 216 36 progressive progressive JJ cord-015922-5wwy0m2k 216 37 respiratory respiratory JJ cord-015922-5wwy0m2k 216 38 failure failure NN cord-015922-5wwy0m2k 216 39 . . . cord-015922-5wwy0m2k 217 1 When when WRB cord-015922-5wwy0m2k 217 2 influenza influenza NN cord-015922-5wwy0m2k 217 3 is be VBZ cord-015922-5wwy0m2k 217 4 identified identify VBN cord-015922-5wwy0m2k 217 5 as as IN cord-015922-5wwy0m2k 217 6 a a DT cord-015922-5wwy0m2k 217 7 pathogen pathogen NN cord-015922-5wwy0m2k 217 8 , , , cord-015922-5wwy0m2k 217 9 use use NN cord-015922-5wwy0m2k 217 10 of of IN cord-015922-5wwy0m2k 217 11 a a DT cord-015922-5wwy0m2k 217 12 neuraminidase neuraminidase NN cord-015922-5wwy0m2k 217 13 inhibitor inhibitor NN cord-015922-5wwy0m2k 217 14 ( ( -LRB- cord-015922-5wwy0m2k 217 15 oseltamvir oseltamvir NNP cord-015922-5wwy0m2k 217 16 or or CC cord-015922-5wwy0m2k 217 17 zanamavir zanamavir NNP cord-015922-5wwy0m2k 217 18 ) ) -RRB- cord-015922-5wwy0m2k 217 19 or or CC cord-015922-5wwy0m2k 217 20 an an DT cord-015922-5wwy0m2k 217 21 amantadate amantadate NN cord-015922-5wwy0m2k 217 22 ( ( -LRB- cord-015922-5wwy0m2k 217 23 amantadine amantadine NNP cord-015922-5wwy0m2k 217 24 or or CC cord-015922-5wwy0m2k 217 25 rimanatine rimanatine NNP cord-015922-5wwy0m2k 217 26 ) ) -RRB- cord-015922-5wwy0m2k 217 27 should should MD cord-015922-5wwy0m2k 217 28 be be VB cord-015922-5wwy0m2k 217 29 considered consider VBN cord-015922-5wwy0m2k 217 30 . . . cord-015922-5wwy0m2k 218 1 The the DT cord-015922-5wwy0m2k 218 2 neuraminidase neuraminidase NN cord-015922-5wwy0m2k 218 3 inhibitors inhibitor NNS cord-015922-5wwy0m2k 218 4 are be VBP cord-015922-5wwy0m2k 218 5 attractive attractive JJ cord-015922-5wwy0m2k 218 6 in in IN cord-015922-5wwy0m2k 218 7 this this DT cord-015922-5wwy0m2k 218 8 setting setting NN cord-015922-5wwy0m2k 218 9 as as IN cord-015922-5wwy0m2k 218 10 they -PRON- PRP cord-015922-5wwy0m2k 218 11 are be VBP cord-015922-5wwy0m2k 218 12 effective effective JJ cord-015922-5wwy0m2k 218 13 against against IN cord-015922-5wwy0m2k 218 14 both both DT cord-015922-5wwy0m2k 218 15 influenza influenza NN cord-015922-5wwy0m2k 218 16 A a NN cord-015922-5wwy0m2k 218 17 and and CC cord-015922-5wwy0m2k 218 18 B b NN cord-015922-5wwy0m2k 218 19 and and CC cord-015922-5wwy0m2k 218 20 antiviral antiviral JJ cord-015922-5wwy0m2k 218 21 resistance resistance NN cord-015922-5wwy0m2k 218 22 occurs occur VBZ cord-015922-5wwy0m2k 218 23 more more RBR cord-015922-5wwy0m2k 218 24 slowly slowly RB cord-015922-5wwy0m2k 218 25 compared compare VBN cord-015922-5wwy0m2k 218 26 with with IN cord-015922-5wwy0m2k 218 27 amantadine amantadine NNP cord-015922-5wwy0m2k 218 28 use use NN cord-015922-5wwy0m2k 218 29 . . . cord-015922-5wwy0m2k 219 1 Annual annual JJ cord-015922-5wwy0m2k 219 2 influenza influenza NN cord-015922-5wwy0m2k 219 3 vaccination vaccination NN cord-015922-5wwy0m2k 219 4 should should MD cord-015922-5wwy0m2k 219 5 be be VB cord-015922-5wwy0m2k 219 6 considered consider VBN cord-015922-5wwy0m2k 219 7 , , , cord-015922-5wwy0m2k 219 8 but but CC cord-015922-5wwy0m2k 219 9 its -PRON- PRP$ cord-015922-5wwy0m2k 219 10 benefit benefit NN cord-015922-5wwy0m2k 219 11 is be VBZ cord-015922-5wwy0m2k 219 12 attenuated attenuate VBN cord-015922-5wwy0m2k 219 13 ; ; : cord-015922-5wwy0m2k 219 14 indeed indeed RB cord-015922-5wwy0m2k 219 15 , , , cord-015922-5wwy0m2k 219 16 it -PRON- PRP cord-015922-5wwy0m2k 219 17 is be VBZ cord-015922-5wwy0m2k 219 18 probably probably RB cord-015922-5wwy0m2k 219 19 fair fair JJ cord-015922-5wwy0m2k 219 20 to to TO cord-015922-5wwy0m2k 219 21 say say VB cord-015922-5wwy0m2k 219 22 that that IN cord-015922-5wwy0m2k 219 23 maximal maximal JJ cord-015922-5wwy0m2k 219 24 benefit benefit NN cord-015922-5wwy0m2k 219 25 from from IN cord-015922-5wwy0m2k 219 26 vaccination vaccination NN cord-015922-5wwy0m2k 219 27 occurs occur VBZ cord-015922-5wwy0m2k 219 28 when when WRB cord-015922-5wwy0m2k 219 29 the the DT cord-015922-5wwy0m2k 219 30 vaccine vaccine NN cord-015922-5wwy0m2k 219 31 is be VBZ cord-015922-5wwy0m2k 219 32 administered administer VBN cord-015922-5wwy0m2k 219 33 to to IN cord-015922-5wwy0m2k 219 34 health health NN cord-015922-5wwy0m2k 219 35 care care NN cord-015922-5wwy0m2k 219 36 workers worker NNS cord-015922-5wwy0m2k 219 37 , , , cord-015922-5wwy0m2k 219 38 family family NN cord-015922-5wwy0m2k 219 39 , , , cord-015922-5wwy0m2k 219 40 friends friend NNS cord-015922-5wwy0m2k 219 41 and and CC cord-015922-5wwy0m2k 219 42 other other JJ cord-015922-5wwy0m2k 219 43 contacts contact NNS cord-015922-5wwy0m2k 219 44 of of IN cord-015922-5wwy0m2k 219 45 the the DT cord-015922-5wwy0m2k 219 46 patient patient NN cord-015922-5wwy0m2k 219 47 . . . cord-015922-5wwy0m2k 220 1 When when WRB cord-015922-5wwy0m2k 220 2 an an DT cord-015922-5wwy0m2k 220 3 infection infection NN cord-015922-5wwy0m2k 220 4 is be VBZ cord-015922-5wwy0m2k 220 5 diagnosed diagnose VBN cord-015922-5wwy0m2k 220 6 , , , cord-015922-5wwy0m2k 220 7 early early JJ cord-015922-5wwy0m2k 220 8 treatment treatment NN cord-015922-5wwy0m2k 220 9 should should MD cord-015922-5wwy0m2k 220 10 be be VB cord-015922-5wwy0m2k 220 11 considered consider VBN cord-015922-5wwy0m2k 220 12 [ [ -LRB- cord-015922-5wwy0m2k 220 13 58 58 CD cord-015922-5wwy0m2k 220 14 , , , cord-015922-5wwy0m2k 220 15 60 60 CD cord-015922-5wwy0m2k 220 16 ] ] -RRB- cord-015922-5wwy0m2k 220 17 . . . cord-015922-5wwy0m2k 221 1 There there EX cord-015922-5wwy0m2k 221 2 are be VBP cord-015922-5wwy0m2k 221 3 more more JJR cord-015922-5wwy0m2k 221 4 than than IN cord-015922-5wwy0m2k 221 5 50 50 CD cord-015922-5wwy0m2k 221 6 serotypes serotype NNS cord-015922-5wwy0m2k 221 7 of of IN cord-015922-5wwy0m2k 221 8 adenovirus adenovirus NN cord-015922-5wwy0m2k 221 9 and and CC cord-015922-5wwy0m2k 221 10 nearly nearly RB cord-015922-5wwy0m2k 221 11 all all DT cord-015922-5wwy0m2k 221 12 have have VBP cord-015922-5wwy0m2k 221 13 been be VBN cord-015922-5wwy0m2k 221 14 described describe VBN cord-015922-5wwy0m2k 221 15 to to TO cord-015922-5wwy0m2k 221 16 cause cause VB cord-015922-5wwy0m2k 221 17 human human JJ cord-015922-5wwy0m2k 221 18 disease disease NN cord-015922-5wwy0m2k 221 19 . . . cord-015922-5wwy0m2k 222 1 Adenovirus Adenovirus NNP cord-015922-5wwy0m2k 222 2 disease disease NN cord-015922-5wwy0m2k 222 3 post post NN cord-015922-5wwy0m2k 222 4 - - NN cord-015922-5wwy0m2k 222 5 transplantation transplantation NN cord-015922-5wwy0m2k 222 6 is be VBZ cord-015922-5wwy0m2k 222 7 likely likely JJ cord-015922-5wwy0m2k 222 8 due due IN cord-015922-5wwy0m2k 222 9 to to IN cord-015922-5wwy0m2k 222 10 both both CC cord-015922-5wwy0m2k 222 11 a a DT cord-015922-5wwy0m2k 222 12 newly newly RB cord-015922-5wwy0m2k 222 13 acquired acquire VBN cord-015922-5wwy0m2k 222 14 virus virus NN cord-015922-5wwy0m2k 222 15 and and CC cord-015922-5wwy0m2k 222 16 viral viral JJ cord-015922-5wwy0m2k 222 17 reactivation reactivation NN cord-015922-5wwy0m2k 222 18 . . . cord-015922-5wwy0m2k 223 1 The the DT cord-015922-5wwy0m2k 223 2 most most RBS cord-015922-5wwy0m2k 223 3 common common JJ cord-015922-5wwy0m2k 223 4 adenovirus adenovirus NN cord-015922-5wwy0m2k 223 5 - - HYPH cord-015922-5wwy0m2k 223 6 associated associate VBN cord-015922-5wwy0m2k 223 7 illness illness NN cord-015922-5wwy0m2k 223 8 post post NN cord-015922-5wwy0m2k 223 9 - - NN cord-015922-5wwy0m2k 223 10 transplantation transplantation NN cord-015922-5wwy0m2k 223 11 is be VBZ cord-015922-5wwy0m2k 223 12 hemorrhagic hemorrhagic JJ cord-015922-5wwy0m2k 223 13 cystitis cystitis NN cord-015922-5wwy0m2k 223 14 which which WDT cord-015922-5wwy0m2k 223 15 has have VBZ cord-015922-5wwy0m2k 223 16 been be VBN cord-015922-5wwy0m2k 223 17 described describe VBN cord-015922-5wwy0m2k 223 18 in in IN cord-015922-5wwy0m2k 223 19 a a DT cord-015922-5wwy0m2k 223 20 recent recent JJ cord-015922-5wwy0m2k 223 21 report report NN cord-015922-5wwy0m2k 223 22 to to TO cord-015922-5wwy0m2k 223 23 occur occur VB cord-015922-5wwy0m2k 223 24 in in IN cord-015922-5wwy0m2k 223 25 up up IN cord-015922-5wwy0m2k 223 26 to to TO cord-015922-5wwy0m2k 223 27 42 42 CD cord-015922-5wwy0m2k 223 28 percent percent NN cord-015922-5wwy0m2k 223 29 of of IN cord-015922-5wwy0m2k 223 30 patients patient NNS cord-015922-5wwy0m2k 223 31 in in IN cord-015922-5wwy0m2k 223 32 the the DT cord-015922-5wwy0m2k 223 33 first first JJ cord-015922-5wwy0m2k 223 34 year year NN cord-015922-5wwy0m2k 223 35 post post NN cord-015922-5wwy0m2k 223 36 - - NN cord-015922-5wwy0m2k 223 37 transplantation transplantation JJ cord-015922-5wwy0m2k 223 38 [ [ -LRB- cord-015922-5wwy0m2k 223 39 61 61 CD cord-015922-5wwy0m2k 223 40 ] ] -RRB- cord-015922-5wwy0m2k 223 41 . . . cord-015922-5wwy0m2k 224 1 The the DT cord-015922-5wwy0m2k 224 2 overwhelming overwhelming JJ cord-015922-5wwy0m2k 224 3 majority majority NN cord-015922-5wwy0m2k 224 4 of of IN cord-015922-5wwy0m2k 224 5 cases case NNS cord-015922-5wwy0m2k 224 6 are be VBP cord-015922-5wwy0m2k 224 7 asymptomatic asymptomatic JJ cord-015922-5wwy0m2k 224 8 and and CC cord-015922-5wwy0m2k 224 9 require require VBP cord-015922-5wwy0m2k 224 10 no no DT cord-015922-5wwy0m2k 224 11 intervention intervention NN cord-015922-5wwy0m2k 224 12 [ [ -LRB- cord-015922-5wwy0m2k 224 13 62 62 CD cord-015922-5wwy0m2k 224 14 ] ] -RRB- cord-015922-5wwy0m2k 224 15 . . . cord-015922-5wwy0m2k 225 1 Occasionally occasionally RB cord-015922-5wwy0m2k 225 2 the the DT cord-015922-5wwy0m2k 225 3 severity severity NN cord-015922-5wwy0m2k 225 4 of of IN cord-015922-5wwy0m2k 225 5 hemorrhage hemorrhage NN cord-015922-5wwy0m2k 225 6 or or CC cord-015922-5wwy0m2k 225 7 bladder bladder NN cord-015922-5wwy0m2k 225 8 - - HYPH cord-015922-5wwy0m2k 225 9 associated associate VBN cord-015922-5wwy0m2k 225 10 pain pain NN cord-015922-5wwy0m2k 225 11 is be VBZ cord-015922-5wwy0m2k 225 12 so so RB cord-015922-5wwy0m2k 225 13 great great JJ cord-015922-5wwy0m2k 225 14 that that IN cord-015922-5wwy0m2k 225 15 intervention intervention NN cord-015922-5wwy0m2k 225 16 is be VBZ cord-015922-5wwy0m2k 225 17 required require VBN cord-015922-5wwy0m2k 225 18 . . . cord-015922-5wwy0m2k 226 1 Other other JJ cord-015922-5wwy0m2k 226 2 important important JJ cord-015922-5wwy0m2k 226 3 adenovirus adenovirus NN cord-015922-5wwy0m2k 226 4 - - HYPH cord-015922-5wwy0m2k 226 5 associated associate VBN cord-015922-5wwy0m2k 226 6 syndromes syndrome NNS cord-015922-5wwy0m2k 226 7 include include VBP cord-015922-5wwy0m2k 226 8 hepatitis hepatitis NN cord-015922-5wwy0m2k 226 9 and and CC cord-015922-5wwy0m2k 226 10 pneumonitis pneumonitis NN cord-015922-5wwy0m2k 226 11 which which WDT cord-015922-5wwy0m2k 226 12 may may MD cord-015922-5wwy0m2k 226 13 be be VB cord-015922-5wwy0m2k 226 14 fatal fatal JJ cord-015922-5wwy0m2k 226 15 in in IN cord-015922-5wwy0m2k 226 16 the the DT cord-015922-5wwy0m2k 226 17 early early JJ cord-015922-5wwy0m2k 226 18 post post JJ cord-015922-5wwy0m2k 226 19 - - JJ cord-015922-5wwy0m2k 226 20 transplant transplant JJ cord-015922-5wwy0m2k 226 21 period period NN cord-015922-5wwy0m2k 226 22 . . . cord-015922-5wwy0m2k 227 1 In in IN cord-015922-5wwy0m2k 227 2 the the DT cord-015922-5wwy0m2k 227 3 late late JJ cord-015922-5wwy0m2k 227 4 post post JJ cord-015922-5wwy0m2k 227 5 - - JJ cord-015922-5wwy0m2k 227 6 transplant transplant JJ cord-015922-5wwy0m2k 227 7 period period NN cord-015922-5wwy0m2k 227 8 adenovirus adenovirus NN cord-015922-5wwy0m2k 227 9 gastroenteritis gastroenteritis NN cord-015922-5wwy0m2k 227 10 may may MD cord-015922-5wwy0m2k 227 11 occur occur VB cord-015922-5wwy0m2k 227 12 which which WDT cord-015922-5wwy0m2k 227 13 is be VBZ cord-015922-5wwy0m2k 227 14 often often RB cord-015922-5wwy0m2k 227 15 a a DT cord-015922-5wwy0m2k 227 16 self self NN cord-015922-5wwy0m2k 227 17 - - HYPH cord-015922-5wwy0m2k 227 18 limited limit VBN cord-015922-5wwy0m2k 227 19 illness illness NN cord-015922-5wwy0m2k 227 20 ; ; : cord-015922-5wwy0m2k 227 21 however however RB cord-015922-5wwy0m2k 227 22 , , , cord-015922-5wwy0m2k 227 23 severe severe JJ cord-015922-5wwy0m2k 227 24 disease disease NN cord-015922-5wwy0m2k 227 25 has have VBZ cord-015922-5wwy0m2k 227 26 been be VBN cord-015922-5wwy0m2k 227 27 described describe VBN cord-015922-5wwy0m2k 227 28 especially especially RB cord-015922-5wwy0m2k 227 29 in in IN cord-015922-5wwy0m2k 227 30 patients patient NNS cord-015922-5wwy0m2k 227 31 requiring require VBG cord-015922-5wwy0m2k 227 32 significant significant JJ cord-015922-5wwy0m2k 227 33 levels level NNS cord-015922-5wwy0m2k 227 34 of of IN cord-015922-5wwy0m2k 227 35 immunosuppression immunosuppression NN cord-015922-5wwy0m2k 227 36 for for IN cord-015922-5wwy0m2k 227 37 GVHD GVHD NNP cord-015922-5wwy0m2k 227 38 . . . cord-015922-5wwy0m2k 228 1 Therapeutic therapeutic JJ cord-015922-5wwy0m2k 228 2 options option NNS cord-015922-5wwy0m2k 228 3 for for IN cord-015922-5wwy0m2k 228 4 adenovirus adenovirus NN cord-015922-5wwy0m2k 228 5 are be VBP cord-015922-5wwy0m2k 228 6 limited limit VBN cord-015922-5wwy0m2k 228 7 . . . cord-015922-5wwy0m2k 229 1 The the DT cord-015922-5wwy0m2k 229 2 role role NN cord-015922-5wwy0m2k 229 3 of of IN cord-015922-5wwy0m2k 229 4 the the DT cord-015922-5wwy0m2k 229 5 antiviral antiviral JJ cord-015922-5wwy0m2k 229 6 cidofovir cidofovir NNS cord-015922-5wwy0m2k 229 7 is be VBZ cord-015922-5wwy0m2k 229 8 controversial controversial JJ cord-015922-5wwy0m2k 229 9 with with IN cord-015922-5wwy0m2k 229 10 mixed mixed JJ cord-015922-5wwy0m2k 229 11 results result NNS cord-015922-5wwy0m2k 229 12 having have VBG cord-015922-5wwy0m2k 229 13 been be VBN cord-015922-5wwy0m2k 229 14 reported report VBN cord-015922-5wwy0m2k 229 15 [ [ -LRB- cord-015922-5wwy0m2k 229 16 63 63 CD cord-015922-5wwy0m2k 229 17 ] ] -RRB- cord-015922-5wwy0m2k 229 18 . . . cord-015922-5wwy0m2k 230 1 Decreasing decrease VBG cord-015922-5wwy0m2k 230 2 immunusuppression immunusuppression NN cord-015922-5wwy0m2k 230 3 and and CC cord-015922-5wwy0m2k 230 4 attempting attempt VBG cord-015922-5wwy0m2k 230 5 reconstitution reconstitution NN cord-015922-5wwy0m2k 230 6 of of IN cord-015922-5wwy0m2k 230 7 the the DT cord-015922-5wwy0m2k 230 8 native native JJ cord-015922-5wwy0m2k 230 9 host host NN cord-015922-5wwy0m2k 230 10 immune immune JJ cord-015922-5wwy0m2k 230 11 response response NN cord-015922-5wwy0m2k 230 12 is be VBZ cord-015922-5wwy0m2k 230 13 critical critical JJ cord-015922-5wwy0m2k 230 14 . . . cord-015922-5wwy0m2k 231 1 The the DT cord-015922-5wwy0m2k 231 2 role role NN cord-015922-5wwy0m2k 231 3 for for IN cord-015922-5wwy0m2k 231 4 other other JJ cord-015922-5wwy0m2k 231 5 adjunctive adjunctive JJ cord-015922-5wwy0m2k 231 6 therapies therapy NNS cord-015922-5wwy0m2k 231 7 , , , cord-015922-5wwy0m2k 231 8 such such JJ cord-015922-5wwy0m2k 231 9 as as IN cord-015922-5wwy0m2k 231 10 IVIg IVIg NNP cord-015922-5wwy0m2k 231 11 , , , cord-015922-5wwy0m2k 231 12 is be VBZ cord-015922-5wwy0m2k 231 13 unproven unproven JJ cord-015922-5wwy0m2k 231 14 , , , cord-015922-5wwy0m2k 231 15 but but CC cord-015922-5wwy0m2k 231 16 can can MD cord-015922-5wwy0m2k 231 17 be be VB cord-015922-5wwy0m2k 231 18 considered consider VBN cord-015922-5wwy0m2k 231 19 in in IN cord-015922-5wwy0m2k 231 20 severe severe JJ cord-015922-5wwy0m2k 231 21 cases case NNS cord-015922-5wwy0m2k 231 22 . . . cord-015922-5wwy0m2k 232 1 Avoiding avoid VBG cord-015922-5wwy0m2k 232 2 exposure exposure NN cord-015922-5wwy0m2k 232 3 to to IN cord-015922-5wwy0m2k 232 4 new new JJ cord-015922-5wwy0m2k 232 5 infection infection NN cord-015922-5wwy0m2k 232 6 , , , cord-015922-5wwy0m2k 232 7 as as IN cord-015922-5wwy0m2k 232 8 with with IN cord-015922-5wwy0m2k 232 9 all all DT cord-015922-5wwy0m2k 232 10 community community NN cord-015922-5wwy0m2k 232 11 - - HYPH cord-015922-5wwy0m2k 232 12 acquired acquire VBN cord-015922-5wwy0m2k 232 13 pathogens pathogen NNS cord-015922-5wwy0m2k 232 14 , , , cord-015922-5wwy0m2k 232 15 is be VBZ cord-015922-5wwy0m2k 232 16 central central JJ cord-015922-5wwy0m2k 232 17 to to TO cord-015922-5wwy0m2k 232 18 optimal optimal JJ cord-015922-5wwy0m2k 232 19 care care NN cord-015922-5wwy0m2k 232 20 . . . cord-015922-5wwy0m2k 233 1 Parainfluenza Parainfluenza NNP cord-015922-5wwy0m2k 233 2 , , , cord-015922-5wwy0m2k 233 3 rhinoviruses rhinovirus NNS cord-015922-5wwy0m2k 233 4 , , , cord-015922-5wwy0m2k 233 5 metapneumovirus metapneumovirus NNP cord-015922-5wwy0m2k 233 6 and and CC cord-015922-5wwy0m2k 233 7 coronaviruses coronaviruse NNS cord-015922-5wwy0m2k 233 8 are be VBP cord-015922-5wwy0m2k 233 9 all all DT cord-015922-5wwy0m2k 233 10 capable capable JJ cord-015922-5wwy0m2k 233 11 of of IN cord-015922-5wwy0m2k 233 12 causing cause VBG cord-015922-5wwy0m2k 233 13 lower low JJR cord-015922-5wwy0m2k 233 14 respiratory respiratory JJ cord-015922-5wwy0m2k 233 15 tract tract NN cord-015922-5wwy0m2k 233 16 infection infection NN cord-015922-5wwy0m2k 233 17 in in IN cord-015922-5wwy0m2k 233 18 HSCT HSCT NNP cord-015922-5wwy0m2k 233 19 recipients recipient NNS cord-015922-5wwy0m2k 233 20 . . . cord-015922-5wwy0m2k 234 1 Of of IN cord-015922-5wwy0m2k 234 2 these these DT cord-015922-5wwy0m2k 234 3 many many JJ cord-015922-5wwy0m2k 234 4 viruses virus NNS cord-015922-5wwy0m2k 234 5 , , , cord-015922-5wwy0m2k 234 6 parainfluenza parainfluenza NNP cord-015922-5wwy0m2k 234 7 virus virus NNP cord-015922-5wwy0m2k 234 8 type type NN cord-015922-5wwy0m2k 234 9 III III NNP cord-015922-5wwy0m2k 234 10 is be VBZ cord-015922-5wwy0m2k 234 11 especially especially RB cord-015922-5wwy0m2k 234 12 associated associate VBN cord-015922-5wwy0m2k 234 13 with with IN cord-015922-5wwy0m2k 234 14 a a DT cord-015922-5wwy0m2k 234 15 high high JJ cord-015922-5wwy0m2k 234 16 mortality mortality NN cord-015922-5wwy0m2k 234 17 [ [ -LRB- cord-015922-5wwy0m2k 234 18 64 64 CD cord-015922-5wwy0m2k 234 19 , , , cord-015922-5wwy0m2k 234 20 65 65 CD cord-015922-5wwy0m2k 234 21 ] ] -RRB- cord-015922-5wwy0m2k 234 22 . . . cord-015922-5wwy0m2k 235 1 Again again RB cord-015922-5wwy0m2k 235 2 , , , cord-015922-5wwy0m2k 235 3 specific specific JJ cord-015922-5wwy0m2k 235 4 therapy therapy NN cord-015922-5wwy0m2k 235 5 is be VBZ cord-015922-5wwy0m2k 235 6 not not RB cord-015922-5wwy0m2k 235 7 available available JJ cord-015922-5wwy0m2k 235 8 , , , cord-015922-5wwy0m2k 235 9 emphasizing emphasize VBG cord-015922-5wwy0m2k 235 10 infection infection NN cord-015922-5wwy0m2k 235 11 control control NN cord-015922-5wwy0m2k 235 12 strategies strategy NNS cord-015922-5wwy0m2k 235 13 in in IN cord-015922-5wwy0m2k 235 14 the the DT cord-015922-5wwy0m2k 235 15 hospital hospital NN cord-015922-5wwy0m2k 235 16 setting setting NN cord-015922-5wwy0m2k 235 17 and and CC cord-015922-5wwy0m2k 235 18 avoiding avoid VBG cord-015922-5wwy0m2k 235 19 individuals individual NNS cord-015922-5wwy0m2k 235 20 with with IN cord-015922-5wwy0m2k 235 21 respiratory respiratory JJ cord-015922-5wwy0m2k 235 22 tract tract NN cord-015922-5wwy0m2k 235 23 complaints complaint NNS cord-015922-5wwy0m2k 235 24 at at IN cord-015922-5wwy0m2k 235 25 home home NN cord-015922-5wwy0m2k 235 26 . . . cord-015922-5wwy0m2k 236 1 When when WRB cord-015922-5wwy0m2k 236 2 upper upper JJ cord-015922-5wwy0m2k 236 3 respiratory respiratory JJ cord-015922-5wwy0m2k 236 4 tract tract NN cord-015922-5wwy0m2k 236 5 complaints complaint NNS cord-015922-5wwy0m2k 236 6 occur occur VBP cord-015922-5wwy0m2k 236 7 in in IN cord-015922-5wwy0m2k 236 8 HSCT HSCT NNP cord-015922-5wwy0m2k 236 9 patients patient NNS cord-015922-5wwy0m2k 236 10 , , , cord-015922-5wwy0m2k 236 11 a a DT cord-015922-5wwy0m2k 236 12 diagnosis diagnosis NN cord-015922-5wwy0m2k 236 13 should should MD cord-015922-5wwy0m2k 236 14 be be VB cord-015922-5wwy0m2k 236 15 made make VBN cord-015922-5wwy0m2k 236 16 , , , cord-015922-5wwy0m2k 236 17 utilizing utilize VBG cord-015922-5wwy0m2k 236 18 rapid rapid JJ cord-015922-5wwy0m2k 236 19 diagnostic diagnostic JJ cord-015922-5wwy0m2k 236 20 techniques technique NNS cord-015922-5wwy0m2k 236 21 ( ( -LRB- cord-015922-5wwy0m2k 236 22 e.g. e.g. RB cord-015922-5wwy0m2k 236 23 , , , cord-015922-5wwy0m2k 236 24 antigen antigen NN cord-015922-5wwy0m2k 236 25 detection detection NN cord-015922-5wwy0m2k 236 26 assays assay NNS cord-015922-5wwy0m2k 236 27 or or CC cord-015922-5wwy0m2k 236 28 nucleic nucleic JJ cord-015922-5wwy0m2k 236 29 acid acid NN cord-015922-5wwy0m2k 236 30 testing testing NN cord-015922-5wwy0m2k 236 31 ) ) -RRB- cord-015922-5wwy0m2k 236 32 . . . cord-015922-5wwy0m2k 237 1 Preemptive preemptive JJ cord-015922-5wwy0m2k 237 2 therapy therapy NN cord-015922-5wwy0m2k 237 3 , , , cord-015922-5wwy0m2k 237 4 when when WRB cord-015922-5wwy0m2k 237 5 available available JJ cord-015922-5wwy0m2k 237 6 , , , cord-015922-5wwy0m2k 237 7 should should MD cord-015922-5wwy0m2k 237 8 be be VB cord-015922-5wwy0m2k 237 9 initiated initiate VBN cord-015922-5wwy0m2k 237 10 , , , cord-015922-5wwy0m2k 237 11 while while IN cord-015922-5wwy0m2k 237 12 immunosuppressive immunosuppressive JJ cord-015922-5wwy0m2k 237 13 therapy therapy NN cord-015922-5wwy0m2k 237 14 diminished diminish VBD cord-015922-5wwy0m2k 237 15 and and CC cord-015922-5wwy0m2k 237 16 isolation isolation NN cord-015922-5wwy0m2k 237 17 from from IN cord-015922-5wwy0m2k 237 18 other other JJ cord-015922-5wwy0m2k 237 19 HSCT HSCT NNP cord-015922-5wwy0m2k 237 20 patients patient NNS cord-015922-5wwy0m2k 237 21 should should MD cord-015922-5wwy0m2k 237 22 be be VB cord-015922-5wwy0m2k 237 23 accomplished accomplish VBN cord-015922-5wwy0m2k 237 24 . . . cord-015922-5wwy0m2k 238 1 BK BK NNP cord-015922-5wwy0m2k 238 2 and and CC cord-015922-5wwy0m2k 238 3 JC JC NNP cord-015922-5wwy0m2k 238 4 viruses virus NNS cord-015922-5wwy0m2k 238 5 are be VBP cord-015922-5wwy0m2k 238 6 the the DT cord-015922-5wwy0m2k 238 7 two two CD cord-015922-5wwy0m2k 238 8 important important JJ cord-015922-5wwy0m2k 238 9 species specie NNS cord-015922-5wwy0m2k 238 10 in in IN cord-015922-5wwy0m2k 238 11 this this DT cord-015922-5wwy0m2k 238 12 family family NN cord-015922-5wwy0m2k 238 13 of of IN cord-015922-5wwy0m2k 238 14 viruses virus NNS cord-015922-5wwy0m2k 238 15 with with IN cord-015922-5wwy0m2k 238 16 a a DT cord-015922-5wwy0m2k 238 17 genitourinary genitourinary JJ cord-015922-5wwy0m2k 238 18 and and CC cord-015922-5wwy0m2k 238 19 CNS cns JJ cord-015922-5wwy0m2k 238 20 predilection predilection NN cord-015922-5wwy0m2k 238 21 , , , cord-015922-5wwy0m2k 238 22 respectively respectively RB cord-015922-5wwy0m2k 238 23 . . . cord-015922-5wwy0m2k 239 1 Approximately approximately RB cord-015922-5wwy0m2k 239 2 60 60 CD cord-015922-5wwy0m2k 239 3 to to TO cord-015922-5wwy0m2k 239 4 80 80 CD cord-015922-5wwy0m2k 239 5 percent percent NN cord-015922-5wwy0m2k 239 6 of of IN cord-015922-5wwy0m2k 239 7 adults adult NNS cord-015922-5wwy0m2k 239 8 have have VBP cord-015922-5wwy0m2k 239 9 been be VBN cord-015922-5wwy0m2k 239 10 infected infect VBN cord-015922-5wwy0m2k 239 11 with with IN cord-015922-5wwy0m2k 239 12 one one CD cord-015922-5wwy0m2k 239 13 or or CC cord-015922-5wwy0m2k 239 14 both both DT cord-015922-5wwy0m2k 239 15 of of IN cord-015922-5wwy0m2k 239 16 these these DT cord-015922-5wwy0m2k 239 17 viruses virus NNS cord-015922-5wwy0m2k 239 18 , , , cord-015922-5wwy0m2k 239 19 typically typically RB cord-015922-5wwy0m2k 239 20 in in IN cord-015922-5wwy0m2k 239 21 childhood childhood NN cord-015922-5wwy0m2k 239 22 . . . cord-015922-5wwy0m2k 240 1 With with IN cord-015922-5wwy0m2k 240 2 immunosuppression immunosuppression NN cord-015922-5wwy0m2k 240 3 , , , cord-015922-5wwy0m2k 240 4 reactivation reactivation NN cord-015922-5wwy0m2k 240 5 occurs occur VBZ cord-015922-5wwy0m2k 240 6 which which WDT cord-015922-5wwy0m2k 240 7 may may MD cord-015922-5wwy0m2k 240 8 lead lead VB cord-015922-5wwy0m2k 240 9 to to IN cord-015922-5wwy0m2k 240 10 disease disease NN cord-015922-5wwy0m2k 240 11 . . . cord-015922-5wwy0m2k 241 1 BK BK NNP cord-015922-5wwy0m2k 241 2 virus virus NN cord-015922-5wwy0m2k 241 3 is be VBZ cord-015922-5wwy0m2k 241 4 associated associate VBN cord-015922-5wwy0m2k 241 5 with with IN cord-015922-5wwy0m2k 241 6 hemorrhagic hemorrhagic JJ cord-015922-5wwy0m2k 241 7 cystitis cystitis NN cord-015922-5wwy0m2k 241 8 in in IN cord-015922-5wwy0m2k 241 9 the the DT cord-015922-5wwy0m2k 241 10 early early JJ cord-015922-5wwy0m2k 241 11 post post JJ cord-015922-5wwy0m2k 241 12 - - JJ cord-015922-5wwy0m2k 241 13 transplant transplant JJ cord-015922-5wwy0m2k 241 14 period period NN cord-015922-5wwy0m2k 241 15 . . . cord-015922-5wwy0m2k 242 1 This this DT cord-015922-5wwy0m2k 242 2 virus virus NN cord-015922-5wwy0m2k 242 3 is be VBZ cord-015922-5wwy0m2k 242 4 commonly commonly RB cord-015922-5wwy0m2k 242 5 found find VBN cord-015922-5wwy0m2k 242 6 in in IN cord-015922-5wwy0m2k 242 7 the the DT cord-015922-5wwy0m2k 242 8 urine urine NN cord-015922-5wwy0m2k 242 9 and and CC cord-015922-5wwy0m2k 242 10 rarely rarely RB cord-015922-5wwy0m2k 242 11 requires require VBZ cord-015922-5wwy0m2k 242 12 any any DT cord-015922-5wwy0m2k 242 13 therapeutic therapeutic JJ cord-015922-5wwy0m2k 242 14 intervention intervention NN cord-015922-5wwy0m2k 242 15 . . . cord-015922-5wwy0m2k 243 1 JC JC NNP cord-015922-5wwy0m2k 243 2 virus virus NN cord-015922-5wwy0m2k 243 3 is be VBZ cord-015922-5wwy0m2k 243 4 the the DT cord-015922-5wwy0m2k 243 5 etiologic etiologic JJ cord-015922-5wwy0m2k 243 6 agent agent NN cord-015922-5wwy0m2k 243 7 of of IN cord-015922-5wwy0m2k 243 8 progressive progressive JJ cord-015922-5wwy0m2k 243 9 multifocal multifocal JJ cord-015922-5wwy0m2k 243 10 leukoencephalopathy leukoencephalopathy NNS cord-015922-5wwy0m2k 243 11 ( ( -LRB- cord-015922-5wwy0m2k 243 12 PML PML NNP cord-015922-5wwy0m2k 243 13 ) ) -RRB- cord-015922-5wwy0m2k 243 14 which which WDT cord-015922-5wwy0m2k 243 15 is be VBZ cord-015922-5wwy0m2k 243 16 a a DT cord-015922-5wwy0m2k 243 17 rare rare JJ cord-015922-5wwy0m2k 243 18 , , , cord-015922-5wwy0m2k 243 19 but but CC cord-015922-5wwy0m2k 243 20 severe severe JJ cord-015922-5wwy0m2k 243 21 post post JJ cord-015922-5wwy0m2k 243 22 - - JJ cord-015922-5wwy0m2k 243 23 transplant transplant JJ cord-015922-5wwy0m2k 243 24 complication complication NN cord-015922-5wwy0m2k 243 25 . . . cord-015922-5wwy0m2k 244 1 PML PML NNP cord-015922-5wwy0m2k 244 2 involves involve VBZ cord-015922-5wwy0m2k 244 3 the the DT cord-015922-5wwy0m2k 244 4 white white JJ cord-015922-5wwy0m2k 244 5 matter matter NN cord-015922-5wwy0m2k 244 6 and and CC cord-015922-5wwy0m2k 244 7 presents present VBZ cord-015922-5wwy0m2k 244 8 with with IN cord-015922-5wwy0m2k 244 9 focal focal JJ cord-015922-5wwy0m2k 244 10 neurologic neurologic JJ cord-015922-5wwy0m2k 244 11 symptoms symptom NNS cord-015922-5wwy0m2k 244 12 associated associate VBN cord-015922-5wwy0m2k 244 13 with with IN cord-015922-5wwy0m2k 244 14 the the DT cord-015922-5wwy0m2k 244 15 specific specific JJ cord-015922-5wwy0m2k 244 16 area area NN cord-015922-5wwy0m2k 244 17 of of IN cord-015922-5wwy0m2k 244 18 the the DT cord-015922-5wwy0m2k 244 19 CNS CNS NNP cord-015922-5wwy0m2k 244 20 where where WRB cord-015922-5wwy0m2k 244 21 the the DT cord-015922-5wwy0m2k 244 22 lesion(s lesion(s NNP cord-015922-5wwy0m2k 244 23 ) ) -RRB- cord-015922-5wwy0m2k 244 24 occur occur VB cord-015922-5wwy0m2k 244 25 . . . cord-015922-5wwy0m2k 245 1 Diagnosis diagnosis NN cord-015922-5wwy0m2k 245 2 requires require VBZ cord-015922-5wwy0m2k 245 3 correlating correlate VBG cord-015922-5wwy0m2k 245 4 the the DT cord-015922-5wwy0m2k 245 5 clinical clinical JJ cord-015922-5wwy0m2k 245 6 presentation presentation NN cord-015922-5wwy0m2k 245 7 , , , cord-015922-5wwy0m2k 245 8 radiographic radiographic JJ cord-015922-5wwy0m2k 245 9 findings finding NNS cord-015922-5wwy0m2k 245 10 ( ( -LRB- cord-015922-5wwy0m2k 245 11 typically typically RB cord-015922-5wwy0m2k 245 12 by by IN cord-015922-5wwy0m2k 245 13 contrast contrast NN cord-015922-5wwy0m2k 245 14 - - HYPH cord-015922-5wwy0m2k 245 15 enhanced enhance VBN cord-015922-5wwy0m2k 245 16 MRI MRI NNP cord-015922-5wwy0m2k 245 17 imaging imaging NN cord-015922-5wwy0m2k 245 18 ) ) -RRB- cord-015922-5wwy0m2k 245 19 and and CC cord-015922-5wwy0m2k 245 20 CSF CSF NNP cord-015922-5wwy0m2k 245 21 PCR PCR NNP cord-015922-5wwy0m2k 245 22 results result NNS cord-015922-5wwy0m2k 245 23 for for IN cord-015922-5wwy0m2k 245 24 JC JC NNP cord-015922-5wwy0m2k 245 25 virus virus NN cord-015922-5wwy0m2k 245 26 . . . cord-015922-5wwy0m2k 246 1 Control Control NNP cord-015922-5wwy0m2k 246 2 of of IN cord-015922-5wwy0m2k 246 3 JC JC NNP cord-015922-5wwy0m2k 246 4 virus virus NN cord-015922-5wwy0m2k 246 5 is be VBZ cord-015922-5wwy0m2k 246 6 associated associate VBN cord-015922-5wwy0m2k 246 7 with with IN cord-015922-5wwy0m2k 246 8 an an DT cord-015922-5wwy0m2k 246 9 intact intact JJ cord-015922-5wwy0m2k 246 10 cell cell NN cord-015922-5wwy0m2k 246 11 - - HYPH cord-015922-5wwy0m2k 246 12 mediated mediate VBN cord-015922-5wwy0m2k 246 13 immune immune JJ cord-015922-5wwy0m2k 246 14 response response NN cord-015922-5wwy0m2k 246 15 . . . cord-015922-5wwy0m2k 247 1 Therapy therapy NN cord-015922-5wwy0m2k 247 2 for for IN cord-015922-5wwy0m2k 247 3 polyomavirus polyomavirus JJ cord-015922-5wwy0m2k 247 4 infection infection NN cord-015922-5wwy0m2k 247 5 is be VBZ cord-015922-5wwy0m2k 247 6 quite quite RB cord-015922-5wwy0m2k 247 7 limited limited JJ cord-015922-5wwy0m2k 247 8 with with IN cord-015922-5wwy0m2k 247 9 minimizing minimize VBG cord-015922-5wwy0m2k 247 10 immunsuppression immunsuppression NN cord-015922-5wwy0m2k 247 11 , , , cord-015922-5wwy0m2k 247 12 when when WRB cord-015922-5wwy0m2k 247 13 possible possible JJ cord-015922-5wwy0m2k 247 14 , , , cord-015922-5wwy0m2k 247 15 being be VBG cord-015922-5wwy0m2k 247 16 critical critical JJ cord-015922-5wwy0m2k 247 17 . . . cord-015922-5wwy0m2k 248 1 The the DT cord-015922-5wwy0m2k 248 2 role role NN cord-015922-5wwy0m2k 248 3 of of IN cord-015922-5wwy0m2k 248 4 cidofovir cidofovir NNP cord-015922-5wwy0m2k 248 5 is be VBZ cord-015922-5wwy0m2k 248 6 controversial controversial JJ cord-015922-5wwy0m2k 248 7 with with IN cord-015922-5wwy0m2k 248 8 mixed mixed JJ cord-015922-5wwy0m2k 248 9 results result NNS cord-015922-5wwy0m2k 248 10 being be VBG cord-015922-5wwy0m2k 248 11 reported report VBN cord-015922-5wwy0m2k 248 12 . . . cord-015922-5wwy0m2k 249 1 The the DT cord-015922-5wwy0m2k 249 2 use use NN cord-015922-5wwy0m2k 249 3 of of IN cord-015922-5wwy0m2k 249 4 quinolones quinolone NNS cord-015922-5wwy0m2k 249 5 for for IN cord-015922-5wwy0m2k 249 6 BK BK NNP cord-015922-5wwy0m2k 249 7 viruria viruria NNP cord-015922-5wwy0m2k 249 8 is be VBZ cord-015922-5wwy0m2k 249 9 controversial controversial JJ cord-015922-5wwy0m2k 249 10 at at IN cord-015922-5wwy0m2k 249 11 best good JJS cord-015922-5wwy0m2k 249 12 and and CC cord-015922-5wwy0m2k 249 13 we -PRON- PRP cord-015922-5wwy0m2k 249 14 do do VBP cord-015922-5wwy0m2k 249 15 not not RB cord-015922-5wwy0m2k 249 16 recommend recommend VB cord-015922-5wwy0m2k 249 17 this this DT cord-015922-5wwy0m2k 249 18 practice practice NN cord-015922-5wwy0m2k 249 19 [ [ -LRB- cord-015922-5wwy0m2k 249 20 66 66 CD cord-015922-5wwy0m2k 249 21 ] ] -RRB- cord-015922-5wwy0m2k 249 22 . . . cord-015922-5wwy0m2k 250 1 Although although IN cord-015922-5wwy0m2k 250 2 the the DT cord-015922-5wwy0m2k 250 3 use use NN cord-015922-5wwy0m2k 250 4 of of IN cord-015922-5wwy0m2k 250 5 gatifloxacin gatifloxacin NNS cord-015922-5wwy0m2k 250 6 was be VBD cord-015922-5wwy0m2k 250 7 advocated advocate VBN cord-015922-5wwy0m2k 250 8 by by IN cord-015922-5wwy0m2k 250 9 some some DT cord-015922-5wwy0m2k 250 10 authors author NNS cord-015922-5wwy0m2k 250 11 , , , cord-015922-5wwy0m2k 250 12 this this DT cord-015922-5wwy0m2k 250 13 drug drug NN cord-015922-5wwy0m2k 250 14 is be VBZ cord-015922-5wwy0m2k 250 15 no no DT cord-015922-5wwy0m2k 250 16 longer long RBR cord-015922-5wwy0m2k 250 17 available available JJ cord-015922-5wwy0m2k 250 18 . . . cord-015922-5wwy0m2k 251 1 Leflunomide Leflunomide NNP cord-015922-5wwy0m2k 251 2 administration administration NN cord-015922-5wwy0m2k 251 3 has have VBZ cord-015922-5wwy0m2k 251 4 been be VBN cord-015922-5wwy0m2k 251 5 used use VBN cord-015922-5wwy0m2k 251 6 by by IN cord-015922-5wwy0m2k 251 7 some some DT cord-015922-5wwy0m2k 251 8 for for IN cord-015922-5wwy0m2k 251 9 treatment treatment NN cord-015922-5wwy0m2k 251 10 of of IN cord-015922-5wwy0m2k 251 11 BK BK NNP cord-015922-5wwy0m2k 251 12 in in IN cord-015922-5wwy0m2k 251 13 renal renal JJ cord-015922-5wwy0m2k 251 14 transplant transplant NN cord-015922-5wwy0m2k 251 15 patients patient NNS cord-015922-5wwy0m2k 251 16 , , , cord-015922-5wwy0m2k 251 17 but but CC cord-015922-5wwy0m2k 251 18 no no DT cord-015922-5wwy0m2k 251 19 randomized randomized JJ cord-015922-5wwy0m2k 251 20 trial trial NN cord-015922-5wwy0m2k 251 21 data data NN cord-015922-5wwy0m2k 251 22 exists exist VBZ cord-015922-5wwy0m2k 251 23 to to TO cord-015922-5wwy0m2k 251 24 support support VB cord-015922-5wwy0m2k 251 25 or or CC cord-015922-5wwy0m2k 251 26 recommend recommend VB cord-015922-5wwy0m2k 251 27 its -PRON- PRP$ cord-015922-5wwy0m2k 251 28 use use NN cord-015922-5wwy0m2k 251 29 in in IN cord-015922-5wwy0m2k 251 30 either either CC cord-015922-5wwy0m2k 251 31 kidney kidney NN cord-015922-5wwy0m2k 251 32 or or CC cord-015922-5wwy0m2k 251 33 HSCT HSCT NNP cord-015922-5wwy0m2k 251 34 recipients recipient NNS cord-015922-5wwy0m2k 251 35 at at IN cord-015922-5wwy0m2k 251 36 this this DT cord-015922-5wwy0m2k 251 37 time time NN cord-015922-5wwy0m2k 251 38 . . . cord-015922-5wwy0m2k 252 1 Hepatitis Hepatitis NNP cord-015922-5wwy0m2k 252 2 B B NNP cord-015922-5wwy0m2k 252 3 and and CC cord-015922-5wwy0m2k 252 4 C c NN cord-015922-5wwy0m2k 252 5 viruses virus NNS cord-015922-5wwy0m2k 252 6 may may MD cord-015922-5wwy0m2k 252 7 cause cause VB cord-015922-5wwy0m2k 252 8 chronic chronic JJ cord-015922-5wwy0m2k 252 9 infection infection NN cord-015922-5wwy0m2k 252 10 which which WDT cord-015922-5wwy0m2k 252 11 often often RB cord-015922-5wwy0m2k 252 12 leads lead VBZ cord-015922-5wwy0m2k 252 13 to to IN cord-015922-5wwy0m2k 252 14 eventual eventual JJ cord-015922-5wwy0m2k 252 15 significant significant JJ cord-015922-5wwy0m2k 252 16 liver liver NN cord-015922-5wwy0m2k 252 17 dysfunction dysfunction NN cord-015922-5wwy0m2k 252 18 . . . cord-015922-5wwy0m2k 253 1 Given give VBN cord-015922-5wwy0m2k 253 2 the the DT cord-015922-5wwy0m2k 253 3 high high JJ cord-015922-5wwy0m2k 253 4 global global JJ cord-015922-5wwy0m2k 253 5 prevalence prevalence NN cord-015922-5wwy0m2k 253 6 of of IN cord-015922-5wwy0m2k 253 7 these these DT cord-015922-5wwy0m2k 253 8 viruses virus NNS cord-015922-5wwy0m2k 253 9 , , , cord-015922-5wwy0m2k 253 10 it -PRON- PRP cord-015922-5wwy0m2k 253 11 is be VBZ cord-015922-5wwy0m2k 253 12 prudent prudent JJ cord-015922-5wwy0m2k 253 13 to to TO cord-015922-5wwy0m2k 253 14 screen screen VB cord-015922-5wwy0m2k 253 15 for for IN cord-015922-5wwy0m2k 253 16 past past JJ cord-015922-5wwy0m2k 253 17 or or CC cord-015922-5wwy0m2k 253 18 current current JJ cord-015922-5wwy0m2k 253 19 infection infection NN cord-015922-5wwy0m2k 253 20 prior prior RB cord-015922-5wwy0m2k 253 21 to to IN cord-015922-5wwy0m2k 253 22 transplantation transplantation NN cord-015922-5wwy0m2k 253 23 . . . cord-015922-5wwy0m2k 254 1 When when WRB cord-015922-5wwy0m2k 254 2 ongoing ongoing JJ cord-015922-5wwy0m2k 254 3 infection infection NN cord-015922-5wwy0m2k 254 4 is be VBZ cord-015922-5wwy0m2k 254 5 found find VBN cord-015922-5wwy0m2k 254 6 , , , cord-015922-5wwy0m2k 254 7 careful careful JJ cord-015922-5wwy0m2k 254 8 assessment assessment NN cord-015922-5wwy0m2k 254 9 of of IN cord-015922-5wwy0m2k 254 10 liver liver NN cord-015922-5wwy0m2k 254 11 function function NN cord-015922-5wwy0m2k 254 12 and and CC cord-015922-5wwy0m2k 254 13 a a DT cord-015922-5wwy0m2k 254 14 pre pre JJ cord-015922-5wwy0m2k 254 15 - - JJ cord-015922-5wwy0m2k 254 16 transplant transplant JJ cord-015922-5wwy0m2k 254 17 liver liver NN cord-015922-5wwy0m2k 254 18 biopsy biopsy NN cord-015922-5wwy0m2k 254 19 should should MD cord-015922-5wwy0m2k 254 20 be be VB cord-015922-5wwy0m2k 254 21 considered consider VBN cord-015922-5wwy0m2k 254 22 to to TO cord-015922-5wwy0m2k 254 23 assess assess VB cord-015922-5wwy0m2k 254 24 for for IN cord-015922-5wwy0m2k 254 25 occult occult JJ cord-015922-5wwy0m2k 254 26 cirrhosis cirrhosis NN cord-015922-5wwy0m2k 254 27 , , , cord-015922-5wwy0m2k 254 28 as as IN cord-015922-5wwy0m2k 254 29 this this DT cord-015922-5wwy0m2k 254 30 may may MD cord-015922-5wwy0m2k 254 31 influence influence VB cord-015922-5wwy0m2k 254 32 peri peri NN cord-015922-5wwy0m2k 254 33 - - HYPH cord-015922-5wwy0m2k 254 34 transplant transplant NN cord-015922-5wwy0m2k 254 35 management management NN cord-015922-5wwy0m2k 254 36 [ [ -LRB- cord-015922-5wwy0m2k 254 37 67 67 CD cord-015922-5wwy0m2k 254 38 ] ] -RRB- cord-015922-5wwy0m2k 254 39 . . . cord-015922-5wwy0m2k 255 1 HBV HBV NNP cord-015922-5wwy0m2k 255 2 infects infect VBZ cord-015922-5wwy0m2k 255 3 approximately approximately RB cord-015922-5wwy0m2k 255 4 350 350 CD cord-015922-5wwy0m2k 255 5 million million CD cord-015922-5wwy0m2k 255 6 people people NNS cord-015922-5wwy0m2k 255 7 worldwide worldwide RB cord-015922-5wwy0m2k 255 8 chronically chronically RB cord-015922-5wwy0m2k 255 9 , , , cord-015922-5wwy0m2k 255 10 and and CC cord-015922-5wwy0m2k 255 11 substantially substantially RB cord-015922-5wwy0m2k 255 12 more more JJR cord-015922-5wwy0m2k 255 13 have have VBP cord-015922-5wwy0m2k 255 14 had have VBN cord-015922-5wwy0m2k 255 15 prior prior RB cord-015922-5wwy0m2k 255 16 resolved resolve VBN cord-015922-5wwy0m2k 255 17 infection infection NN cord-015922-5wwy0m2k 255 18 . . . cord-015922-5wwy0m2k 256 1 The the DT cord-015922-5wwy0m2k 256 2 use use NN cord-015922-5wwy0m2k 256 3 of of IN cord-015922-5wwy0m2k 256 4 the the DT cord-015922-5wwy0m2k 256 5 HBV HBV NNP cord-015922-5wwy0m2k 256 6 vaccine vaccine NN cord-015922-5wwy0m2k 256 7 as as IN cord-015922-5wwy0m2k 256 8 a a DT cord-015922-5wwy0m2k 256 9 routine routine JJ cord-015922-5wwy0m2k 256 10 childhood childhood NN cord-015922-5wwy0m2k 256 11 immunization immunization NN cord-015922-5wwy0m2k 256 12 will will MD cord-015922-5wwy0m2k 256 13 likely likely RB cord-015922-5wwy0m2k 256 14 decrease decrease VB cord-015922-5wwy0m2k 256 15 the the DT cord-015922-5wwy0m2k 256 16 number number NN cord-015922-5wwy0m2k 256 17 of of IN cord-015922-5wwy0m2k 256 18 chronically chronically RB cord-015922-5wwy0m2k 256 19 infected infect VBN cord-015922-5wwy0m2k 256 20 individuals individual NNS cord-015922-5wwy0m2k 256 21 over over IN cord-015922-5wwy0m2k 256 22 the the DT cord-015922-5wwy0m2k 256 23 next next JJ cord-015922-5wwy0m2k 256 24 several several JJ cord-015922-5wwy0m2k 256 25 decades decade NNS cord-015922-5wwy0m2k 256 26 . . . cord-015922-5wwy0m2k 257 1 The the DT cord-015922-5wwy0m2k 257 2 advent advent NN cord-015922-5wwy0m2k 257 3 of of IN cord-015922-5wwy0m2k 257 4 nucleic nucleic JJ cord-015922-5wwy0m2k 257 5 acid acid NN cord-015922-5wwy0m2k 257 6 detection detection NN cord-015922-5wwy0m2k 257 7 technology technology NN cord-015922-5wwy0m2k 257 8 has have VBZ cord-015922-5wwy0m2k 257 9 allowed allow VBN cord-015922-5wwy0m2k 257 10 a a DT cord-015922-5wwy0m2k 257 11 more more RBR cord-015922-5wwy0m2k 257 12 precise precise JJ cord-015922-5wwy0m2k 257 13 mechanism mechanism NN cord-015922-5wwy0m2k 257 14 to to TO cord-015922-5wwy0m2k 257 15 detect detect VB cord-015922-5wwy0m2k 257 16 active active JJ cord-015922-5wwy0m2k 257 17 HBV HBV NNP cord-015922-5wwy0m2k 257 18 replication replication NN cord-015922-5wwy0m2k 257 19 compared compare VBN cord-015922-5wwy0m2k 257 20 with with IN cord-015922-5wwy0m2k 257 21 antigen-(for antigen-(for NNP cord-015922-5wwy0m2k 257 22 surface surface NN cord-015922-5wwy0m2k 257 23 and and CC cord-015922-5wwy0m2k 257 24 e e LS cord-015922-5wwy0m2k 257 25 ) ) -RRB- cord-015922-5wwy0m2k 257 26 only only JJ cord-015922-5wwy0m2k 257 27 methods method NNS cord-015922-5wwy0m2k 257 28 . . . cord-015922-5wwy0m2k 258 1 For for IN cord-015922-5wwy0m2k 258 2 patients patient NNS cord-015922-5wwy0m2k 258 3 with with IN cord-015922-5wwy0m2k 258 4 evidence evidence NN cord-015922-5wwy0m2k 258 5 of of IN cord-015922-5wwy0m2k 258 6 prior prior JJ cord-015922-5wwy0m2k 258 7 HBV HBV NNP cord-015922-5wwy0m2k 258 8 exposure exposure NN cord-015922-5wwy0m2k 258 9 ( ( -LRB- cord-015922-5wwy0m2k 258 10 HBV HBV NNP cord-015922-5wwy0m2k 258 11 core core NN cord-015922-5wwy0m2k 258 12 antibody antibody NN cord-015922-5wwy0m2k 258 13 positive positive JJ cord-015922-5wwy0m2k 258 14 ) ) -RRB- cord-015922-5wwy0m2k 258 15 , , , cord-015922-5wwy0m2k 258 16 it -PRON- PRP cord-015922-5wwy0m2k 258 17 is be VBZ cord-015922-5wwy0m2k 258 18 important important JJ cord-015922-5wwy0m2k 258 19 to to TO cord-015922-5wwy0m2k 258 20 consider consider VB cord-015922-5wwy0m2k 258 21 HBV HBV NNP cord-015922-5wwy0m2k 258 22 reactivation reactivation NN cord-015922-5wwy0m2k 258 23 in in IN cord-015922-5wwy0m2k 258 24 the the DT cord-015922-5wwy0m2k 258 25 setting setting NN cord-015922-5wwy0m2k 258 26 of of IN cord-015922-5wwy0m2k 258 27 post post JJ cord-015922-5wwy0m2k 258 28 - - JJ cord-015922-5wwy0m2k 258 29 transplant transplant JJ cord-015922-5wwy0m2k 258 30 liver liver NN cord-015922-5wwy0m2k 258 31 dysfunction dysfunction NN cord-015922-5wwy0m2k 258 32 and and CC cord-015922-5wwy0m2k 258 33 to to TO cord-015922-5wwy0m2k 258 34 differentiate differentiate VB cord-015922-5wwy0m2k 258 35 this this DT cord-015922-5wwy0m2k 258 36 from from IN cord-015922-5wwy0m2k 258 37 other other JJ cord-015922-5wwy0m2k 258 38 causes cause NNS cord-015922-5wwy0m2k 258 39 such such JJ cord-015922-5wwy0m2k 258 40 as as IN cord-015922-5wwy0m2k 258 41 hepatic hepatic JJ cord-015922-5wwy0m2k 258 42 GVHD GVHD NNP cord-015922-5wwy0m2k 258 43 or or CC cord-015922-5wwy0m2k 258 44 medication medication NN cord-015922-5wwy0m2k 258 45 toxicity toxicity NN cord-015922-5wwy0m2k 258 46 , , , cord-015922-5wwy0m2k 258 47 although although IN cord-015922-5wwy0m2k 258 48 reactivation reactivation NN cord-015922-5wwy0m2k 258 49 initially initially RB cord-015922-5wwy0m2k 258 50 occurs occur VBZ cord-015922-5wwy0m2k 258 51 in in IN cord-015922-5wwy0m2k 258 52 the the DT cord-015922-5wwy0m2k 258 53 setting setting NN cord-015922-5wwy0m2k 258 54 of of IN cord-015922-5wwy0m2k 258 55 normal normal JJ cord-015922-5wwy0m2k 258 56 liver liver NN cord-015922-5wwy0m2k 258 57 tests test NNS cord-015922-5wwy0m2k 258 58 . . . cord-015922-5wwy0m2k 259 1 The the DT cord-015922-5wwy0m2k 259 2 best good JJS cord-015922-5wwy0m2k 259 3 strategy strategy NN cord-015922-5wwy0m2k 259 4 for for IN cord-015922-5wwy0m2k 259 5 surveillance surveillance NN cord-015922-5wwy0m2k 259 6 post post JJ cord-015922-5wwy0m2k 259 7 - - NN cord-015922-5wwy0m2k 259 8 transplantation transplantation NN cord-015922-5wwy0m2k 259 9 remains remain VBZ cord-015922-5wwy0m2k 259 10 to to TO cord-015922-5wwy0m2k 259 11 be be VB cord-015922-5wwy0m2k 259 12 defined define VBN cord-015922-5wwy0m2k 259 13 . . . cord-015922-5wwy0m2k 260 1 Some some DT cord-015922-5wwy0m2k 260 2 recommend recommend VBP cord-015922-5wwy0m2k 260 3 routine routine JJ cord-015922-5wwy0m2k 260 4 surveillance surveillance NN cord-015922-5wwy0m2k 260 5 for for IN cord-015922-5wwy0m2k 260 6 HBV HBV NNP cord-015922-5wwy0m2k 260 7 reactivation reactivation NN cord-015922-5wwy0m2k 260 8 post post NN cord-015922-5wwy0m2k 260 9 - - NN cord-015922-5wwy0m2k 260 10 transplantation transplantation NN cord-015922-5wwy0m2k 260 11 , , , cord-015922-5wwy0m2k 260 12 whereas whereas IN cord-015922-5wwy0m2k 260 13 others other NNS cord-015922-5wwy0m2k 260 14 would would MD cord-015922-5wwy0m2k 260 15 suggest suggest VB cord-015922-5wwy0m2k 260 16 antiviral antiviral JJ cord-015922-5wwy0m2k 260 17 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 260 18 . . . cord-015922-5wwy0m2k 261 1 It -PRON- PRP cord-015922-5wwy0m2k 261 2 is be VBZ cord-015922-5wwy0m2k 261 3 important important JJ cord-015922-5wwy0m2k 261 4 to to TO cord-015922-5wwy0m2k 261 5 be be VB cord-015922-5wwy0m2k 261 6 aware aware JJ cord-015922-5wwy0m2k 261 7 that that IN cord-015922-5wwy0m2k 261 8 old old JJ cord-015922-5wwy0m2k 261 9 resolved resolve VBN cord-015922-5wwy0m2k 261 10 infections infection NNS cord-015922-5wwy0m2k 261 11 , , , cord-015922-5wwy0m2k 261 12 including include VBG cord-015922-5wwy0m2k 261 13 those those DT cord-015922-5wwy0m2k 261 14 with with IN cord-015922-5wwy0m2k 261 15 hepatitis hepatitis NN cord-015922-5wwy0m2k 261 16 core core NN cord-015922-5wwy0m2k 261 17 and and CC cord-015922-5wwy0m2k 261 18 surface surface NN cord-015922-5wwy0m2k 261 19 antibody antibody NN cord-015922-5wwy0m2k 261 20 , , , cord-015922-5wwy0m2k 261 21 but but CC cord-015922-5wwy0m2k 261 22 without without IN cord-015922-5wwy0m2k 261 23 antigen antigen NN cord-015922-5wwy0m2k 261 24 or or CC cord-015922-5wwy0m2k 261 25 HBV HBV NNP cord-015922-5wwy0m2k 261 26 DNA DNA NNP cord-015922-5wwy0m2k 261 27 detected detect VBD cord-015922-5wwy0m2k 261 28 , , , cord-015922-5wwy0m2k 261 29 are be VBP cord-015922-5wwy0m2k 261 30 at at IN cord-015922-5wwy0m2k 261 31 risk risk NN cord-015922-5wwy0m2k 261 32 for for IN cord-015922-5wwy0m2k 261 33 reactivation reactivation NN cord-015922-5wwy0m2k 261 34 ( ( -LRB- cord-015922-5wwy0m2k 261 35 seroreversion seroreversion NN cord-015922-5wwy0m2k 261 36 ) ) -RRB- cord-015922-5wwy0m2k 261 37 post post NN cord-015922-5wwy0m2k 261 38 - - NN cord-015922-5wwy0m2k 261 39 transplantation transplantation NN cord-015922-5wwy0m2k 261 40 , , , cord-015922-5wwy0m2k 261 41 especially especially RB cord-015922-5wwy0m2k 261 42 in in IN cord-015922-5wwy0m2k 261 43 the the DT cord-015922-5wwy0m2k 261 44 setting setting NN cord-015922-5wwy0m2k 261 45 of of IN cord-015922-5wwy0m2k 261 46 high high JJ cord-015922-5wwy0m2k 261 47 levels level NNS cord-015922-5wwy0m2k 261 48 of of IN cord-015922-5wwy0m2k 261 49 immunosuppression immunosuppression NN cord-015922-5wwy0m2k 261 50 [ [ -LRB- cord-015922-5wwy0m2k 261 51 68 68 CD cord-015922-5wwy0m2k 261 52 , , , cord-015922-5wwy0m2k 261 53 69 69 CD cord-015922-5wwy0m2k 261 54 ] ] -RRB- cord-015922-5wwy0m2k 261 55 . . . cord-015922-5wwy0m2k 262 1 Several several JJ cord-015922-5wwy0m2k 262 2 therapeutic therapeutic JJ cord-015922-5wwy0m2k 262 3 options option NNS cord-015922-5wwy0m2k 262 4 have have VBP cord-015922-5wwy0m2k 262 5 become become VBN cord-015922-5wwy0m2k 262 6 available available JJ cord-015922-5wwy0m2k 262 7 over over IN cord-015922-5wwy0m2k 262 8 the the DT cord-015922-5wwy0m2k 262 9 last last JJ cord-015922-5wwy0m2k 262 10 several several JJ cord-015922-5wwy0m2k 262 11 years year NNS cord-015922-5wwy0m2k 262 12 and and CC cord-015922-5wwy0m2k 262 13 include include VBP cord-015922-5wwy0m2k 262 14 lamivudine lamivudine JJ cord-015922-5wwy0m2k 262 15 [ [ -LRB- cord-015922-5wwy0m2k 262 16 70 70 CD cord-015922-5wwy0m2k 262 17 ] ] -RRB- cord-015922-5wwy0m2k 262 18 [ [ -LRB- cord-015922-5wwy0m2k 262 19 71 71 CD cord-015922-5wwy0m2k 262 20 ] ] -RRB- cord-015922-5wwy0m2k 262 21 [ [ -LRB- cord-015922-5wwy0m2k 262 22 72 72 CD cord-015922-5wwy0m2k 262 23 ] ] -RRB- cord-015922-5wwy0m2k 262 24 , , , cord-015922-5wwy0m2k 262 25 adefovir adefovir NNP cord-015922-5wwy0m2k 262 26 [ [ -LRB- cord-015922-5wwy0m2k 262 27 73 73 CD cord-015922-5wwy0m2k 262 28 ] ] -RRB- cord-015922-5wwy0m2k 262 29 , , , cord-015922-5wwy0m2k 262 30 entecavir entecavir NNP cord-015922-5wwy0m2k 262 31 [ [ -LRB- cord-015922-5wwy0m2k 262 32 71 71 CD cord-015922-5wwy0m2k 262 33 , , , cord-015922-5wwy0m2k 262 34 72 72 CD cord-015922-5wwy0m2k 262 35 ] ] -RRB- cord-015922-5wwy0m2k 262 36 and and CC cord-015922-5wwy0m2k 262 37 telbivudine telbivudine NNP cord-015922-5wwy0m2k 262 38 . . . cord-015922-5wwy0m2k 263 1 Other other JJ cord-015922-5wwy0m2k 263 2 agents agent NNS cord-015922-5wwy0m2k 263 3 such such JJ cord-015922-5wwy0m2k 263 4 as as IN cord-015922-5wwy0m2k 263 5 tenofovir tenofovir NNP cord-015922-5wwy0m2k 263 6 and and CC cord-015922-5wwy0m2k 263 7 emtricitabine emtricitabine NNP cord-015922-5wwy0m2k 263 8 also also RB cord-015922-5wwy0m2k 263 9 have have VBP cord-015922-5wwy0m2k 263 10 excellent excellent JJ cord-015922-5wwy0m2k 263 11 anti anti JJ cord-015922-5wwy0m2k 263 12 - - JJ cord-015922-5wwy0m2k 263 13 HBV hbv JJ cord-015922-5wwy0m2k 263 14 activity activity NN cord-015922-5wwy0m2k 263 15 . . . cord-015922-5wwy0m2k 264 1 Use use NN cord-015922-5wwy0m2k 264 2 of of IN cord-015922-5wwy0m2k 264 3 these these DT cord-015922-5wwy0m2k 264 4 agents agent NNS cord-015922-5wwy0m2k 264 5 requires require VBZ cord-015922-5wwy0m2k 264 6 careful careful JJ cord-015922-5wwy0m2k 264 7 consideration consideration NN cord-015922-5wwy0m2k 264 8 to to TO cord-015922-5wwy0m2k 264 9 minimize minimize VB cord-015922-5wwy0m2k 264 10 the the DT cord-015922-5wwy0m2k 264 11 risk risk NN cord-015922-5wwy0m2k 264 12 for for IN cord-015922-5wwy0m2k 264 13 the the DT cord-015922-5wwy0m2k 264 14 emergence emergence NN cord-015922-5wwy0m2k 264 15 of of IN cord-015922-5wwy0m2k 264 16 resistant resistant JJ cord-015922-5wwy0m2k 264 17 virus virus NN cord-015922-5wwy0m2k 264 18 , , , cord-015922-5wwy0m2k 264 19 which which WDT cord-015922-5wwy0m2k 264 20 may may MD cord-015922-5wwy0m2k 264 21 be be VB cord-015922-5wwy0m2k 264 22 as as RB cord-015922-5wwy0m2k 264 23 high high JJ cord-015922-5wwy0m2k 264 24 as as IN cord-015922-5wwy0m2k 264 25 10 10 CD cord-015922-5wwy0m2k 264 26 percent percent NN cord-015922-5wwy0m2k 264 27 per per IN cord-015922-5wwy0m2k 264 28 year year NN cord-015922-5wwy0m2k 264 29 for for IN cord-015922-5wwy0m2k 264 30 lamivudine lamivudine NNP cord-015922-5wwy0m2k 264 31 , , , cord-015922-5wwy0m2k 264 32 but but CC cord-015922-5wwy0m2k 264 33 is be VBZ cord-015922-5wwy0m2k 264 34 less less JJR cord-015922-5wwy0m2k 264 35 than than IN cord-015922-5wwy0m2k 264 36 1 1 CD cord-015922-5wwy0m2k 264 37 percent percent NN cord-015922-5wwy0m2k 264 38 for for IN cord-015922-5wwy0m2k 264 39 adefovir adefovir NNP cord-015922-5wwy0m2k 264 40 and and CC cord-015922-5wwy0m2k 264 41 entecavir entecavir NNP cord-015922-5wwy0m2k 264 42 . . . cord-015922-5wwy0m2k 265 1 Epidemiologic epidemiologic JJ cord-015922-5wwy0m2k 265 2 studies study NNS cord-015922-5wwy0m2k 265 3 suggest suggest VBP cord-015922-5wwy0m2k 265 4 that that IN cord-015922-5wwy0m2k 265 5 more more JJR cord-015922-5wwy0m2k 265 6 than than IN cord-015922-5wwy0m2k 265 7 170 170 CD cord-015922-5wwy0m2k 265 8 million million CD cord-015922-5wwy0m2k 265 9 people people NNS cord-015922-5wwy0m2k 265 10 worldwide worldwide RB cord-015922-5wwy0m2k 265 11 have have VBP cord-015922-5wwy0m2k 265 12 been be VBN cord-015922-5wwy0m2k 265 13 infected infect VBN cord-015922-5wwy0m2k 265 14 with with IN cord-015922-5wwy0m2k 265 15 hepatitis hepatitis NN cord-015922-5wwy0m2k 265 16 C C NNP cord-015922-5wwy0m2k 265 17 virus virus NN cord-015922-5wwy0m2k 265 18 ( ( -LRB- cord-015922-5wwy0m2k 265 19 HCV HCV NNP cord-015922-5wwy0m2k 265 20 ) ) -RRB- cord-015922-5wwy0m2k 265 21 and and CC cord-015922-5wwy0m2k 265 22 the the DT cord-015922-5wwy0m2k 265 23 majority majority NN cord-015922-5wwy0m2k 265 24 ( ( -LRB- cord-015922-5wwy0m2k 265 25 approximately approximately RB cord-015922-5wwy0m2k 265 26 85 85 CD cord-015922-5wwy0m2k 265 27 % % NN cord-015922-5wwy0m2k 265 28 ) ) -RRB- cord-015922-5wwy0m2k 265 29 are be VBP cord-015922-5wwy0m2k 265 30 chronically chronically RB cord-015922-5wwy0m2k 265 31 infected infect VBN cord-015922-5wwy0m2k 265 32 [ [ -LRB- cord-015922-5wwy0m2k 265 33 67 67 CD cord-015922-5wwy0m2k 265 34 ] ] -RRB- cord-015922-5wwy0m2k 265 35 . . . cord-015922-5wwy0m2k 266 1 Over over IN cord-015922-5wwy0m2k 266 2 several several JJ cord-015922-5wwy0m2k 266 3 decades decade NNS cord-015922-5wwy0m2k 266 4 , , , cord-015922-5wwy0m2k 266 5 chronic chronic JJ cord-015922-5wwy0m2k 266 6 HCV HCV NNP cord-015922-5wwy0m2k 266 7 infection infection NN cord-015922-5wwy0m2k 266 8 is be VBZ cord-015922-5wwy0m2k 266 9 associated associate VBN cord-015922-5wwy0m2k 266 10 with with IN cord-015922-5wwy0m2k 266 11 progressive progressive JJ cord-015922-5wwy0m2k 266 12 hepatic hepatic JJ cord-015922-5wwy0m2k 266 13 fibrosis fibrosis NN cord-015922-5wwy0m2k 266 14 , , , cord-015922-5wwy0m2k 266 15 liver liver NN cord-015922-5wwy0m2k 266 16 failure failure NN cord-015922-5wwy0m2k 266 17 , , , cord-015922-5wwy0m2k 266 18 and and CC cord-015922-5wwy0m2k 266 19 hepatoma hepatoma NNP cord-015922-5wwy0m2k 266 20 . . . cord-015922-5wwy0m2k 267 1 This this DT cord-015922-5wwy0m2k 267 2 process process NN cord-015922-5wwy0m2k 267 3 is be VBZ cord-015922-5wwy0m2k 267 4 accelerated accelerate VBN cord-015922-5wwy0m2k 267 5 in in IN cord-015922-5wwy0m2k 267 6 certain certain JJ cord-015922-5wwy0m2k 267 7 immunocompromised immunocompromised JJ cord-015922-5wwy0m2k 267 8 patients patient NNS cord-015922-5wwy0m2k 267 9 including include VBG cord-015922-5wwy0m2k 267 10 HSCT HSCT NNP cord-015922-5wwy0m2k 267 11 recipients recipient NNS cord-015922-5wwy0m2k 267 12 [ [ -LRB- cord-015922-5wwy0m2k 267 13 74 74 CD cord-015922-5wwy0m2k 267 14 , , , cord-015922-5wwy0m2k 267 15 75 75 CD cord-015922-5wwy0m2k 267 16 ] ] -RRB- cord-015922-5wwy0m2k 267 17 . . . cord-015922-5wwy0m2k 268 1 It -PRON- PRP cord-015922-5wwy0m2k 268 2 is be VBZ cord-015922-5wwy0m2k 268 3 important important JJ cord-015922-5wwy0m2k 268 4 to to TO cord-015922-5wwy0m2k 268 5 assess assess VB cord-015922-5wwy0m2k 268 6 patients patient NNS cord-015922-5wwy0m2k 268 7 for for IN cord-015922-5wwy0m2k 268 8 seropositivity seropositivity NN cord-015922-5wwy0m2k 268 9 to to IN cord-015922-5wwy0m2k 268 10 HCV HCV NNP cord-015922-5wwy0m2k 268 11 prior prior RB cord-015922-5wwy0m2k 268 12 to to IN cord-015922-5wwy0m2k 268 13 transplantation transplantation NN cord-015922-5wwy0m2k 268 14 and and CC cord-015922-5wwy0m2k 268 15 in in IN cord-015922-5wwy0m2k 268 16 those those DT cord-015922-5wwy0m2k 268 17 who who WP cord-015922-5wwy0m2k 268 18 are be VBP cord-015922-5wwy0m2k 268 19 found find VBN cord-015922-5wwy0m2k 268 20 seropositive seropositive JJ cord-015922-5wwy0m2k 268 21 , , , cord-015922-5wwy0m2k 268 22 to to TO cord-015922-5wwy0m2k 268 23 assess assess VB cord-015922-5wwy0m2k 268 24 the the DT cord-015922-5wwy0m2k 268 25 HCV HCV NNP cord-015922-5wwy0m2k 268 26 viral viral JJ cord-015922-5wwy0m2k 268 27 load load NN cord-015922-5wwy0m2k 268 28 , , , cord-015922-5wwy0m2k 268 29 genotype genotype NN cord-015922-5wwy0m2k 268 30 and and CC cord-015922-5wwy0m2k 268 31 liver liver NN cord-015922-5wwy0m2k 268 32 pathology pathology NN cord-015922-5wwy0m2k 268 33 . . . cord-015922-5wwy0m2k 269 1 The the DT cord-015922-5wwy0m2k 269 2 presence presence NN cord-015922-5wwy0m2k 269 3 of of IN cord-015922-5wwy0m2k 269 4 elevated elevated JJ cord-015922-5wwy0m2k 269 5 liver liver NN cord-015922-5wwy0m2k 269 6 enzymes enzyme NNS cord-015922-5wwy0m2k 269 7 in in IN cord-015922-5wwy0m2k 269 8 the the DT cord-015922-5wwy0m2k 269 9 setting setting NN cord-015922-5wwy0m2k 269 10 of of IN cord-015922-5wwy0m2k 269 11 HCV HCV NNP cord-015922-5wwy0m2k 269 12 before before IN cord-015922-5wwy0m2k 269 13 allogeneic allogeneic NN cord-015922-5wwy0m2k 269 14 HSCT HSCT NNP cord-015922-5wwy0m2k 269 15 has have VBZ cord-015922-5wwy0m2k 269 16 been be VBN cord-015922-5wwy0m2k 269 17 associated associate VBN cord-015922-5wwy0m2k 269 18 with with IN cord-015922-5wwy0m2k 269 19 an an DT cord-015922-5wwy0m2k 269 20 increased increase VBN cord-015922-5wwy0m2k 269 21 incidence incidence NN cord-015922-5wwy0m2k 269 22 of of IN cord-015922-5wwy0m2k 269 23 VOD VOD NNP cord-015922-5wwy0m2k 269 24 [ [ -LRB- cord-015922-5wwy0m2k 269 25 76 76 CD cord-015922-5wwy0m2k 269 26 ] ] -RRB- cord-015922-5wwy0m2k 269 27 . . . cord-015922-5wwy0m2k 270 1 A a DT cord-015922-5wwy0m2k 270 2 more more RBR cord-015922-5wwy0m2k 270 3 precise precise JJ cord-015922-5wwy0m2k 270 4 profiling profiling NN cord-015922-5wwy0m2k 270 5 of of IN cord-015922-5wwy0m2k 270 6 the the DT cord-015922-5wwy0m2k 270 7 HCV HCV NNP cord-015922-5wwy0m2k 270 8 - - HYPH cord-015922-5wwy0m2k 270 9 infected infect VBN cord-015922-5wwy0m2k 270 10 patient patient NN cord-015922-5wwy0m2k 270 11 , , , cord-015922-5wwy0m2k 270 12 including include VBG cord-015922-5wwy0m2k 270 13 liver liver NN cord-015922-5wwy0m2k 270 14 biopsy biopsy NN cord-015922-5wwy0m2k 270 15 , , , cord-015922-5wwy0m2k 270 16 should should MD cord-015922-5wwy0m2k 270 17 be be VB cord-015922-5wwy0m2k 270 18 considered consider VBN cord-015922-5wwy0m2k 270 19 to to TO cord-015922-5wwy0m2k 270 20 better better RB cord-015922-5wwy0m2k 270 21 define define VB cord-015922-5wwy0m2k 270 22 the the DT cord-015922-5wwy0m2k 270 23 extent extent NN cord-015922-5wwy0m2k 270 24 of of IN cord-015922-5wwy0m2k 270 25 the the DT cord-015922-5wwy0m2k 270 26 HCV HCV NNP cord-015922-5wwy0m2k 270 27 - - HYPH cord-015922-5wwy0m2k 270 28 induced induce VBN cord-015922-5wwy0m2k 270 29 liver liver NN cord-015922-5wwy0m2k 270 30 disease disease NN cord-015922-5wwy0m2k 270 31 , , , cord-015922-5wwy0m2k 270 32 and and CC cord-015922-5wwy0m2k 270 33 to to TO cord-015922-5wwy0m2k 270 34 optimize optimize VB cord-015922-5wwy0m2k 270 35 the the DT cord-015922-5wwy0m2k 270 36 conditioning conditioning NN cord-015922-5wwy0m2k 270 37 regimen regimen NN cord-015922-5wwy0m2k 270 38 and and CC cord-015922-5wwy0m2k 270 39 frequency frequency NN cord-015922-5wwy0m2k 270 40 of of IN cord-015922-5wwy0m2k 270 41 surveillance surveillance NN cord-015922-5wwy0m2k 270 42 posttransplantation posttransplantation NN cord-015922-5wwy0m2k 270 43 . . . cord-015922-5wwy0m2k 271 1 Treatment treatment NN cord-015922-5wwy0m2k 271 2 of of IN cord-015922-5wwy0m2k 271 3 HCV HCV NNP cord-015922-5wwy0m2k 271 4 is be VBZ cord-015922-5wwy0m2k 271 5 limited limit VBN cord-015922-5wwy0m2k 271 6 and and CC cord-015922-5wwy0m2k 271 7 typically typically RB cord-015922-5wwy0m2k 271 8 requires require VBZ cord-015922-5wwy0m2k 271 9 use use NN cord-015922-5wwy0m2k 271 10 of of IN cord-015922-5wwy0m2k 271 11 an an DT cord-015922-5wwy0m2k 271 12 interferon interferon NN cord-015922-5wwy0m2k 271 13 and and CC cord-015922-5wwy0m2k 271 14 ribavirin ribavirin NN cord-015922-5wwy0m2k 271 15 which which WDT cord-015922-5wwy0m2k 271 16 are be VBP cord-015922-5wwy0m2k 271 17 likely likely JJ cord-015922-5wwy0m2k 271 18 to to TO cord-015922-5wwy0m2k 271 19 be be VB cord-015922-5wwy0m2k 271 20 poorly poorly RB cord-015922-5wwy0m2k 271 21 tolerated tolerate VBN cord-015922-5wwy0m2k 271 22 in in IN cord-015922-5wwy0m2k 271 23 the the DT cord-015922-5wwy0m2k 271 24 early early JJ cord-015922-5wwy0m2k 271 25 post post JJ cord-015922-5wwy0m2k 271 26 - - JJ cord-015922-5wwy0m2k 271 27 transplant transplant JJ cord-015922-5wwy0m2k 271 28 setting setting NN cord-015922-5wwy0m2k 271 29 . . . cord-015922-5wwy0m2k 272 1 In in IN cord-015922-5wwy0m2k 272 2 patients patient NNS cord-015922-5wwy0m2k 272 3 who who WP cord-015922-5wwy0m2k 272 4 are be VBP cord-015922-5wwy0m2k 272 5 infected infect VBN cord-015922-5wwy0m2k 272 6 , , , cord-015922-5wwy0m2k 272 7 it -PRON- PRP cord-015922-5wwy0m2k 272 8 is be VBZ cord-015922-5wwy0m2k 272 9 prudent prudent JJ cord-015922-5wwy0m2k 272 10 to to TO cord-015922-5wwy0m2k 272 11 counsel counsel VB cord-015922-5wwy0m2k 272 12 them -PRON- PRP cord-015922-5wwy0m2k 272 13 to to TO cord-015922-5wwy0m2k 272 14 avoid avoid VB cord-015922-5wwy0m2k 272 15 hepatotoxins hepatotoxin NNS cord-015922-5wwy0m2k 272 16 , , , cord-015922-5wwy0m2k 272 17 receive receive VB cord-015922-5wwy0m2k 272 18 the the DT cord-015922-5wwy0m2k 272 19 hepatitis hepatitis NN cord-015922-5wwy0m2k 272 20 A a NN cord-015922-5wwy0m2k 272 21 and and CC cord-015922-5wwy0m2k 272 22 B b NN cord-015922-5wwy0m2k 272 23 vaccines vaccine NNS cord-015922-5wwy0m2k 272 24 , , , cord-015922-5wwy0m2k 272 25 and and CC cord-015922-5wwy0m2k 272 26 minimize minimize VB cord-015922-5wwy0m2k 272 27 the the DT cord-015922-5wwy0m2k 272 28 risk risk NN cord-015922-5wwy0m2k 272 29 of of IN cord-015922-5wwy0m2k 272 30 transmission transmission NN cord-015922-5wwy0m2k 272 31 to to TO cord-015922-5wwy0m2k 272 32 close close VB cord-015922-5wwy0m2k 272 33 contacts contact NNS cord-015922-5wwy0m2k 272 34 . . . cord-015922-5wwy0m2k 273 1 There there EX cord-015922-5wwy0m2k 273 2 are be VBP cord-015922-5wwy0m2k 273 3 three three CD cord-015922-5wwy0m2k 273 4 categories category NNS cord-015922-5wwy0m2k 273 5 of of IN cord-015922-5wwy0m2k 273 6 fungal fungal JJ cord-015922-5wwy0m2k 273 7 pathogens pathogen NNS cord-015922-5wwy0m2k 273 8 that that WDT cord-015922-5wwy0m2k 273 9 can can MD cord-015922-5wwy0m2k 273 10 infect infect VB cord-015922-5wwy0m2k 273 11 the the DT cord-015922-5wwy0m2k 273 12 HSCT HSCT NNP cord-015922-5wwy0m2k 273 13 patient patient NN cord-015922-5wwy0m2k 273 14 : : : cord-015922-5wwy0m2k 273 15 a a LS cord-015922-5wwy0m2k 273 16 ) ) -RRB- cord-015922-5wwy0m2k 273 17 the the DT cord-015922-5wwy0m2k 273 18 classic classic JJ cord-015922-5wwy0m2k 273 19 opportunistic opportunistic JJ cord-015922-5wwy0m2k 273 20 fungi fungus NNS cord-015922-5wwy0m2k 273 21 , , , cord-015922-5wwy0m2k 273 22 which which WDT cord-015922-5wwy0m2k 273 23 cause cause VBP cord-015922-5wwy0m2k 273 24 > > XX cord-015922-5wwy0m2k 273 25 90 90 CD cord-015922-5wwy0m2k 273 26 percent percent NN cord-015922-5wwy0m2k 273 27 of of IN cord-015922-5wwy0m2k 273 28 the the DT cord-015922-5wwy0m2k 273 29 invasive invasive JJ cord-015922-5wwy0m2k 273 30 fungal fungal JJ cord-015922-5wwy0m2k 273 31 infections infection NNS cord-015922-5wwy0m2k 273 32 that that WDT cord-015922-5wwy0m2k 273 33 occur occur VBP cord-015922-5wwy0m2k 273 34 in in IN cord-015922-5wwy0m2k 273 35 the the DT cord-015922-5wwy0m2k 273 36 HSCT HSCT NNP cord-015922-5wwy0m2k 273 37 patient patient NN cord-015922-5wwy0m2k 274 1 -Candida -Candida NNP cord-015922-5wwy0m2k 274 2 , , , cord-015922-5wwy0m2k 274 3 Aspergillus Aspergillus NNP cord-015922-5wwy0m2k 274 4 and and CC cord-015922-5wwy0m2k 274 5 Cryptococcus Cryptococcus NNP cord-015922-5wwy0m2k 274 6 being be VBG cord-015922-5wwy0m2k 274 7 the the DT cord-015922-5wwy0m2k 274 8 most most RBS cord-015922-5wwy0m2k 274 9 important important JJ cord-015922-5wwy0m2k 274 10 of of IN cord-015922-5wwy0m2k 274 11 these these DT cord-015922-5wwy0m2k 274 12 infections infection NNS cord-015922-5wwy0m2k 274 13 ; ; : cord-015922-5wwy0m2k 274 14 b b LS cord-015922-5wwy0m2k 274 15 ) ) -RRB- cord-015922-5wwy0m2k 274 16 the the DT cord-015922-5wwy0m2k 274 17 geographically geographically RB cord-015922-5wwy0m2k 274 18 restricted restricted JJ cord-015922-5wwy0m2k 274 19 systemic systemic JJ cord-015922-5wwy0m2k 274 20 mycoses mycose NNS cord-015922-5wwy0m2k 274 21 caused cause VBN cord-015922-5wwy0m2k 274 22 by by IN cord-015922-5wwy0m2k 274 23 Blastomyces Blastomyces NNP cord-015922-5wwy0m2k 274 24 dermatitidis dermatitidis NN cord-015922-5wwy0m2k 274 25 , , , cord-015922-5wwy0m2k 274 26 Coccidioides Coccidioides NNP cord-015922-5wwy0m2k 274 27 immitis immitis NNP cord-015922-5wwy0m2k 274 28 and and CC cord-015922-5wwy0m2k 274 29 Histoplasma Histoplasma NNP cord-015922-5wwy0m2k 274 30 capsulatum capsulatum NN cord-015922-5wwy0m2k 274 31 ; ; : cord-015922-5wwy0m2k 274 32 and and CC cord-015922-5wwy0m2k 274 33 c c LS cord-015922-5wwy0m2k 274 34 ) ) -RRB- cord-015922-5wwy0m2k 274 35 invasive invasive JJ cord-015922-5wwy0m2k 274 36 infection infection NN cord-015922-5wwy0m2k 274 37 due due IN cord-015922-5wwy0m2k 274 38 to to IN cord-015922-5wwy0m2k 274 39 the the DT cord-015922-5wwy0m2k 274 40 so so RB cord-015922-5wwy0m2k 274 41 - - HYPH cord-015922-5wwy0m2k 274 42 called call VBN cord-015922-5wwy0m2k 274 43 " " `` cord-015922-5wwy0m2k 274 44 newly newly RB cord-015922-5wwy0m2k 274 45 emerging emerge VBG cord-015922-5wwy0m2k 274 46 fungi fungus NNS cord-015922-5wwy0m2k 274 47 " " '' cord-015922-5wwy0m2k 274 48 -Fusarium -fusarium NN cord-015922-5wwy0m2k 274 49 , , , cord-015922-5wwy0m2k 274 50 the the DT cord-015922-5wwy0m2k 274 51 zygomycetes zygomycetes NNPS cord-015922-5wwy0m2k 274 52 and and CC cord-015922-5wwy0m2k 274 53 such such JJ cord-015922-5wwy0m2k 274 54 dematiaceous dematiaceous JJ cord-015922-5wwy0m2k 274 55 fungi fungus NNS cord-015922-5wwy0m2k 274 56 as as IN cord-015922-5wwy0m2k 274 57 Scedosporium Scedosporium NNP cord-015922-5wwy0m2k 274 58 , , , cord-015922-5wwy0m2k 274 59 Scopulariopsis Scopulariopsis NNP cord-015922-5wwy0m2k 274 60 and and CC cord-015922-5wwy0m2k 274 61 Dactylaria Dactylaria NNP cord-015922-5wwy0m2k 274 62 [ [ -LRB- cord-015922-5wwy0m2k 274 63 4 4 CD cord-015922-5wwy0m2k 274 64 ] ] -RRB- cord-015922-5wwy0m2k 274 65 . . . cord-015922-5wwy0m2k 275 1 Candida Candida NNP cord-015922-5wwy0m2k 275 2 is be VBZ cord-015922-5wwy0m2k 275 3 a a DT cord-015922-5wwy0m2k 275 4 major major JJ cord-015922-5wwy0m2k 275 5 cause cause NN cord-015922-5wwy0m2k 275 6 of of IN cord-015922-5wwy0m2k 275 7 fungal fungal JJ cord-015922-5wwy0m2k 275 8 bloodstream bloodstream NN cord-015922-5wwy0m2k 275 9 infection infection NN cord-015922-5wwy0m2k 275 10 during during IN cord-015922-5wwy0m2k 275 11 the the DT cord-015922-5wwy0m2k 275 12 preengraftment preengraftment NN cord-015922-5wwy0m2k 275 13 phase phase NN cord-015922-5wwy0m2k 275 14 of of IN cord-015922-5wwy0m2k 275 15 HSCT HSCT NNP cord-015922-5wwy0m2k 275 16 . . . cord-015922-5wwy0m2k 276 1 Although although IN cord-015922-5wwy0m2k 276 2 there there EX cord-015922-5wwy0m2k 276 3 is be VBZ cord-015922-5wwy0m2k 276 4 the the DT cord-015922-5wwy0m2k 276 5 possibility possibility NN cord-015922-5wwy0m2k 276 6 that that IN cord-015922-5wwy0m2k 276 7 the the DT cord-015922-5wwy0m2k 276 8 portal portal NN cord-015922-5wwy0m2k 276 9 of of IN cord-015922-5wwy0m2k 276 10 entry entry NN cord-015922-5wwy0m2k 276 11 can can MD cord-015922-5wwy0m2k 276 12 be be VB cord-015922-5wwy0m2k 276 13 vascular vascular JJ cord-015922-5wwy0m2k 276 14 access access NN cord-015922-5wwy0m2k 276 15 catheters catheter NNS cord-015922-5wwy0m2k 276 16 , , , cord-015922-5wwy0m2k 276 17 it -PRON- PRP cord-015922-5wwy0m2k 276 18 is be VBZ cord-015922-5wwy0m2k 276 19 believed believe VBN cord-015922-5wwy0m2k 276 20 that that IN cord-015922-5wwy0m2k 276 21 translocation translocation NN cord-015922-5wwy0m2k 276 22 of of IN cord-015922-5wwy0m2k 276 23 Candida Candida NNP cord-015922-5wwy0m2k 276 24 species specie NNS cord-015922-5wwy0m2k 276 25 across across IN cord-015922-5wwy0m2k 276 26 gut gut NN cord-015922-5wwy0m2k 276 27 mucosa mucosa NN cord-015922-5wwy0m2k 276 28 damaged damage VBN cord-015922-5wwy0m2k 276 29 by by IN cord-015922-5wwy0m2k 276 30 the the DT cord-015922-5wwy0m2k 276 31 pre pre JJ cord-015922-5wwy0m2k 276 32 - - JJ cord-015922-5wwy0m2k 276 33 transplant transplant JJ cord-015922-5wwy0m2k 276 34 conditioning conditioning NN cord-015922-5wwy0m2k 276 35 regimen regimen NN cord-015922-5wwy0m2k 276 36 is be VBZ cord-015922-5wwy0m2k 276 37 the the DT cord-015922-5wwy0m2k 276 38 major major JJ cord-015922-5wwy0m2k 276 39 route route NN cord-015922-5wwy0m2k 276 40 of of IN cord-015922-5wwy0m2k 276 41 access access NN cord-015922-5wwy0m2k 276 42 to to IN cord-015922-5wwy0m2k 276 43 the the DT cord-015922-5wwy0m2k 276 44 bloodstream bloodstream NN cord-015922-5wwy0m2k 276 45 in in IN cord-015922-5wwy0m2k 276 46 the the DT cord-015922-5wwy0m2k 276 47 granulocytopenic granulocytopenic JJ cord-015922-5wwy0m2k 276 48 patient patient NN cord-015922-5wwy0m2k 276 49 [ [ -LRB- cord-015922-5wwy0m2k 276 50 77 77 CD cord-015922-5wwy0m2k 276 51 , , , cord-015922-5wwy0m2k 276 52 78 78 CD cord-015922-5wwy0m2k 276 53 ] ] -RRB- cord-015922-5wwy0m2k 276 54 . . . cord-015922-5wwy0m2k 277 1 In in IN cord-015922-5wwy0m2k 277 2 the the DT cord-015922-5wwy0m2k 277 3 past past NN cord-015922-5wwy0m2k 277 4 , , , cord-015922-5wwy0m2k 277 5 C. C. NNP cord-015922-5wwy0m2k 277 6 albicans albican NNS cord-015922-5wwy0m2k 277 7 and and CC cord-015922-5wwy0m2k 277 8 C. C. NNP cord-015922-5wwy0m2k 277 9 tropicalis tropicalis NNP cord-015922-5wwy0m2k 277 10 accounted account VBD cord-015922-5wwy0m2k 277 11 for for IN cord-015922-5wwy0m2k 277 12 virtually virtually RB cord-015922-5wwy0m2k 277 13 all all DT cord-015922-5wwy0m2k 277 14 of of IN cord-015922-5wwy0m2k 277 15 the the DT cord-015922-5wwy0m2k 277 16 Candida Candida NNP cord-015922-5wwy0m2k 277 17 bloodstream bloodstream NN cord-015922-5wwy0m2k 277 18 infections infection NNS cord-015922-5wwy0m2k 277 19 . . . cord-015922-5wwy0m2k 278 1 The the DT cord-015922-5wwy0m2k 278 2 incidence incidence NN cord-015922-5wwy0m2k 278 3 of of IN cord-015922-5wwy0m2k 278 4 candidemia candidemia NN cord-015922-5wwy0m2k 278 5 was be VBD cord-015922-5wwy0m2k 278 6 ∼11 ∼11 NN cord-015922-5wwy0m2k 278 7 to to IN cord-015922-5wwy0m2k 278 8 16 16 CD cord-015922-5wwy0m2k 278 9 percent percent NN cord-015922-5wwy0m2k 278 10 ( ( -LRB- cord-015922-5wwy0m2k 278 11 with with IN cord-015922-5wwy0m2k 278 12 a a DT cord-015922-5wwy0m2k 278 13 median median JJ cord-015922-5wwy0m2k 278 14 time time NN cord-015922-5wwy0m2k 278 15 to to IN cord-015922-5wwy0m2k 278 16 onset onset NN cord-015922-5wwy0m2k 278 17 of of IN cord-015922-5wwy0m2k 278 18 two two CD cord-015922-5wwy0m2k 278 19 weeks week NNS cord-015922-5wwy0m2k 278 20 post post NN cord-015922-5wwy0m2k 278 21 - - JJ cord-015922-5wwy0m2k 278 22 transplant transplant JJ cord-015922-5wwy0m2k 278 23 ) ) -RRB- cord-015922-5wwy0m2k 278 24 , , , cord-015922-5wwy0m2k 278 25 resulting result VBG cord-015922-5wwy0m2k 278 26 in in IN cord-015922-5wwy0m2k 278 27 a a DT cord-015922-5wwy0m2k 278 28 high high JJ cord-015922-5wwy0m2k 278 29 rate rate NN cord-015922-5wwy0m2k 278 30 of of IN cord-015922-5wwy0m2k 278 31 tissue tissue NN cord-015922-5wwy0m2k 278 32 invasion invasion NN cord-015922-5wwy0m2k 278 33 and and CC cord-015922-5wwy0m2k 278 34 an an DT cord-015922-5wwy0m2k 278 35 attributable attributable JJ cord-015922-5wwy0m2k 278 36 mortality mortality NN cord-015922-5wwy0m2k 278 37 of of IN cord-015922-5wwy0m2k 278 38 nearly nearly RB cord-015922-5wwy0m2k 278 39 40 40 CD cord-015922-5wwy0m2k 278 40 percent percent NN cord-015922-5wwy0m2k 278 41 [ [ -LRB- cord-015922-5wwy0m2k 278 42 79 79 CD cord-015922-5wwy0m2k 278 43 , , , cord-015922-5wwy0m2k 278 44 80 80 CD cord-015922-5wwy0m2k 278 45 ] ] -RRB- cord-015922-5wwy0m2k 278 46 . . . cord-015922-5wwy0m2k 279 1 With with IN cord-015922-5wwy0m2k 279 2 the the DT cord-015922-5wwy0m2k 279 3 introduction introduction NN cord-015922-5wwy0m2k 279 4 of of IN cord-015922-5wwy0m2k 279 5 empirical empirical JJ cord-015922-5wwy0m2k 279 6 antifungal antifungal NN cord-015922-5wwy0m2k 279 7 therapy therapy NN cord-015922-5wwy0m2k 279 8 or or CC cord-015922-5wwy0m2k 279 9 fluconazole fluconazole NN cord-015922-5wwy0m2k 279 10 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 279 11 ( ( -LRB- cord-015922-5wwy0m2k 279 12 400 400 CD cord-015922-5wwy0m2k 279 13 mg mg NNP cord-015922-5wwy0m2k 279 14 / / SYM cord-015922-5wwy0m2k 279 15 day day NN cord-015922-5wwy0m2k 279 16 ) ) -RRB- cord-015922-5wwy0m2k 279 17 during during IN cord-015922-5wwy0m2k 279 18 the the DT cord-015922-5wwy0m2k 279 19 preengraftment preengraftment JJ cord-015922-5wwy0m2k 279 20 period period NN cord-015922-5wwy0m2k 279 21 , , , cord-015922-5wwy0m2k 279 22 the the DT cord-015922-5wwy0m2k 279 23 incidence incidence NN cord-015922-5wwy0m2k 279 24 of of IN cord-015922-5wwy0m2k 279 25 candidemia candidemia NN cord-015922-5wwy0m2k 279 26 has have VBZ cord-015922-5wwy0m2k 279 27 been be VBN cord-015922-5wwy0m2k 279 28 significantly significantly RB cord-015922-5wwy0m2k 279 29 decreased decrease VBN cord-015922-5wwy0m2k 279 30 , , , cord-015922-5wwy0m2k 279 31 hepatosplenic hepatosplenic NNP cord-015922-5wwy0m2k 279 32 candidiasis candidiasis NN cord-015922-5wwy0m2k 279 33 has have VBZ cord-015922-5wwy0m2k 279 34 become become VBN cord-015922-5wwy0m2k 279 35 quite quite RB cord-015922-5wwy0m2k 279 36 rare rare JJ cord-015922-5wwy0m2k 279 37 , , , cord-015922-5wwy0m2k 279 38 and and CC cord-015922-5wwy0m2k 279 39 the the DT cord-015922-5wwy0m2k 279 40 attributable attributable JJ cord-015922-5wwy0m2k 279 41 mortality mortality NN cord-015922-5wwy0m2k 279 42 has have VBZ cord-015922-5wwy0m2k 279 43 been be VBN cord-015922-5wwy0m2k 279 44 significantly significantly RB cord-015922-5wwy0m2k 279 45 decreased decrease VBN cord-015922-5wwy0m2k 279 46 . . . cord-015922-5wwy0m2k 280 1 Fluconazole fluconazole NN cord-015922-5wwy0m2k 280 2 - - HYPH cord-015922-5wwy0m2k 280 3 resistant resistant JJ cord-015922-5wwy0m2k 280 4 Candida Candida NNP cord-015922-5wwy0m2k 280 5 sp sp NN cord-015922-5wwy0m2k 280 6 , , , cord-015922-5wwy0m2k 280 7 C. C. NNP cord-015922-5wwy0m2k 280 8 krusei krusei NNP cord-015922-5wwy0m2k 280 9 and and CC cord-015922-5wwy0m2k 280 10 C. C. NNP cord-015922-5wwy0m2k 280 11 glabrata glabrata NNP cord-015922-5wwy0m2k 280 12 , , , cord-015922-5wwy0m2k 280 13 have have VBP cord-015922-5wwy0m2k 280 14 emerged emerge VBN cord-015922-5wwy0m2k 280 15 as as IN cord-015922-5wwy0m2k 280 16 not not RB cord-015922-5wwy0m2k 280 17 uncommon uncommon JJ cord-015922-5wwy0m2k 280 18 causes cause NNS cord-015922-5wwy0m2k 280 19 of of IN cord-015922-5wwy0m2k 280 20 candidemia candidemia NN cord-015922-5wwy0m2k 280 21 in in IN cord-015922-5wwy0m2k 280 22 HSCT HSCT NNP cord-015922-5wwy0m2k 280 23 patients patient NNS cord-015922-5wwy0m2k 280 24 , , , cord-015922-5wwy0m2k 280 25 as as IN cord-015922-5wwy0m2k 280 26 have have VBP cord-015922-5wwy0m2k 280 27 the the DT cord-015922-5wwy0m2k 280 28 other other JJ cord-015922-5wwy0m2k 280 29 non non NNS cord-015922-5wwy0m2k 280 30 - - JJ cord-015922-5wwy0m2k 280 31 albicans albicans JJ cord-015922-5wwy0m2k 280 32 Candida candida NN cord-015922-5wwy0m2k 280 33 species specie NNS cord-015922-5wwy0m2k 280 34 [ [ -LRB- cord-015922-5wwy0m2k 280 35 1 1 CD cord-015922-5wwy0m2k 280 36 , , , cord-015922-5wwy0m2k 280 37 4 4 CD cord-015922-5wwy0m2k 280 38 , , , cord-015922-5wwy0m2k 280 39 [ [ -LRB- cord-015922-5wwy0m2k 280 40 81 81 CD cord-015922-5wwy0m2k 280 41 ] ] -RRB- cord-015922-5wwy0m2k 280 42 [ [ -LRB- cord-015922-5wwy0m2k 280 43 82 82 CD cord-015922-5wwy0m2k 280 44 ] ] -RRB- cord-015922-5wwy0m2k 280 45 [ [ -LRB- cord-015922-5wwy0m2k 280 46 83 83 CD cord-015922-5wwy0m2k 280 47 ] ] -RRB- cord-015922-5wwy0m2k 280 48 [ [ -LRB- cord-015922-5wwy0m2k 280 49 84 84 CD cord-015922-5wwy0m2k 280 50 ] ] -RRB- cord-015922-5wwy0m2k 280 51 [ [ -LRB- cord-015922-5wwy0m2k 280 52 85 85 CD cord-015922-5wwy0m2k 280 53 ] ] -RRB- cord-015922-5wwy0m2k 280 54 [ [ -LRB- cord-015922-5wwy0m2k 280 55 86 86 CD cord-015922-5wwy0m2k 280 56 ] ] -RRB- cord-015922-5wwy0m2k 280 57 [ [ -LRB- cord-015922-5wwy0m2k 280 58 87 87 CD cord-015922-5wwy0m2k 280 59 ] ] -RRB- cord-015922-5wwy0m2k 280 60 . . . cord-015922-5wwy0m2k 281 1 It -PRON- PRP cord-015922-5wwy0m2k 281 2 is be VBZ cord-015922-5wwy0m2k 281 3 also also RB cord-015922-5wwy0m2k 281 4 important important JJ cord-015922-5wwy0m2k 281 5 to to TO cord-015922-5wwy0m2k 281 6 recognize recognize VB cord-015922-5wwy0m2k 281 7 that that IN cord-015922-5wwy0m2k 281 8 other other JJ cord-015922-5wwy0m2k 281 9 species specie NNS cord-015922-5wwy0m2k 281 10 of of IN cord-015922-5wwy0m2k 281 11 yeast yeast NN cord-015922-5wwy0m2k 281 12 ( ( -LRB- cord-015922-5wwy0m2k 281 13 e.g. e.g. RB cord-015922-5wwy0m2k 281 14 , , , cord-015922-5wwy0m2k 281 15 Trichosporon Trichosporon NNP cord-015922-5wwy0m2k 281 16 sp sp NNP cord-015922-5wwy0m2k 281 17 , , , cord-015922-5wwy0m2k 281 18 Blastoschyzomyces Blastoschyzomyces NNP cord-015922-5wwy0m2k 281 19 capitatus capitatus NN cord-015922-5wwy0m2k 281 20 , , , cord-015922-5wwy0m2k 281 21 Saccharomyces Saccharomyces NNP cord-015922-5wwy0m2k 281 22 cereviseae cereviseae NN cord-015922-5wwy0m2k 281 23 and and CC cord-015922-5wwy0m2k 281 24 Rhodotorula Rhodotorula NNP cord-015922-5wwy0m2k 281 25 sp sp NN cord-015922-5wwy0m2k 281 26 . . . cord-015922-5wwy0m2k 281 27 ) ) -RRB- cord-015922-5wwy0m2k 281 28 can can MD cord-015922-5wwy0m2k 281 29 cause cause VB cord-015922-5wwy0m2k 281 30 clinical clinical JJ cord-015922-5wwy0m2k 281 31 syndromes syndrome NNS cord-015922-5wwy0m2k 281 32 identical identical JJ cord-015922-5wwy0m2k 281 33 to to IN cord-015922-5wwy0m2k 281 34 those those DT cord-015922-5wwy0m2k 281 35 observed observe VBN cord-015922-5wwy0m2k 281 36 with with IN cord-015922-5wwy0m2k 281 37 invasive invasive JJ cord-015922-5wwy0m2k 281 38 candidiasis candidiasi NNS cord-015922-5wwy0m2k 281 39 ( ( -LRB- cord-015922-5wwy0m2k 281 40 bloodstream bloodstream NN cord-015922-5wwy0m2k 281 41 infection infection NN cord-015922-5wwy0m2k 281 42 , , , cord-015922-5wwy0m2k 281 43 infection infection NN cord-015922-5wwy0m2k 281 44 metastatic metastatic JJ cord-015922-5wwy0m2k 281 45 to to IN cord-015922-5wwy0m2k 281 46 the the DT cord-015922-5wwy0m2k 281 47 skin skin NN cord-015922-5wwy0m2k 281 48 and and CC cord-015922-5wwy0m2k 281 49 subcutaneous subcutaneous JJ cord-015922-5wwy0m2k 281 50 tissues tissue NNS cord-015922-5wwy0m2k 281 51 , , , cord-015922-5wwy0m2k 281 52 as as RB cord-015922-5wwy0m2k 281 53 well well RB cord-015922-5wwy0m2k 281 54 as as IN cord-015922-5wwy0m2k 281 55 other other JJ cord-015922-5wwy0m2k 281 56 sites site NNS cord-015922-5wwy0m2k 281 57 , , , cord-015922-5wwy0m2k 281 58 including include VBG cord-015922-5wwy0m2k 281 59 hepatosplenic hepatosplenic NNP cord-015922-5wwy0m2k 281 60 disease disease NN cord-015922-5wwy0m2k 281 61 identical identical JJ cord-015922-5wwy0m2k 281 62 to to IN cord-015922-5wwy0m2k 281 63 that that DT cord-015922-5wwy0m2k 281 64 caused cause VBN cord-015922-5wwy0m2k 281 65 by by IN cord-015922-5wwy0m2k 281 66 Candida Candida NNP cord-015922-5wwy0m2k 281 67 species specie NNS cord-015922-5wwy0m2k 281 68 ) ) -RRB- cord-015922-5wwy0m2k 282 1 [ [ -LRB- cord-015922-5wwy0m2k 282 2 88 88 CD cord-015922-5wwy0m2k 282 3 ] ] -RRB- cord-015922-5wwy0m2k 282 4 . . . cord-015922-5wwy0m2k 283 1 In in IN cord-015922-5wwy0m2k 283 2 an an DT cord-015922-5wwy0m2k 283 3 era era NN cord-015922-5wwy0m2k 283 4 of of IN cord-015922-5wwy0m2k 283 5 increased increase VBN cord-015922-5wwy0m2k 283 6 use use NN cord-015922-5wwy0m2k 283 7 of of IN cord-015922-5wwy0m2k 283 8 echinocandins echinocandin NNS cord-015922-5wwy0m2k 283 9 for for IN cord-015922-5wwy0m2k 283 10 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 283 11 [ [ -LRB- cord-015922-5wwy0m2k 283 12 89 89 CD cord-015922-5wwy0m2k 283 13 ] ] -RRB- cord-015922-5wwy0m2k 283 14 and and CC cord-015922-5wwy0m2k 283 15 empirical empirical JJ cord-015922-5wwy0m2k 283 16 antifungal antifungal JJ cord-015922-5wwy0m2k 283 17 treatment treatment NN cord-015922-5wwy0m2k 283 18 [ [ -LRB- cord-015922-5wwy0m2k 283 19 90 90 CD cord-015922-5wwy0m2k 283 20 ] ] -RRB- cord-015922-5wwy0m2k 283 21 , , , cord-015922-5wwy0m2k 283 22 these these DT cord-015922-5wwy0m2k 283 23 organisms organism NNS cord-015922-5wwy0m2k 283 24 [ [ -LRB- cord-015922-5wwy0m2k 283 25 88 88 CD cord-015922-5wwy0m2k 283 26 , , , cord-015922-5wwy0m2k 283 27 91 91 CD cord-015922-5wwy0m2k 283 28 ] ] -RRB- cord-015922-5wwy0m2k 283 29 and and CC cord-015922-5wwy0m2k 283 30 echinocandin echinocandin NN cord-015922-5wwy0m2k 283 31 - - HYPH cord-015922-5wwy0m2k 283 32 resistant resistant JJ cord-015922-5wwy0m2k 283 33 Candida Candida NNP cord-015922-5wwy0m2k 283 34 sp sp NN cord-015922-5wwy0m2k 283 35 , , , cord-015922-5wwy0m2k 283 36 especially especially RB cord-015922-5wwy0m2k 283 37 C. C. NNP cord-015922-5wwy0m2k 283 38 parapsilopsis parapsilopsis NNP cord-015922-5wwy0m2k 283 39 , , , cord-015922-5wwy0m2k 283 40 have have VBP cord-015922-5wwy0m2k 283 41 become become VBN cord-015922-5wwy0m2k 283 42 emerging emerge VBG cord-015922-5wwy0m2k 283 43 causes cause NNS cord-015922-5wwy0m2k 283 44 of of IN cord-015922-5wwy0m2k 283 45 fungemia fungemia NN cord-015922-5wwy0m2k 283 46 in in IN cord-015922-5wwy0m2k 283 47 the the DT cord-015922-5wwy0m2k 283 48 HSCT HSCT NNP cord-015922-5wwy0m2k 283 49 units unit NNS cord-015922-5wwy0m2k 283 50 [ [ -LRB- cord-015922-5wwy0m2k 283 51 1 1 CD cord-015922-5wwy0m2k 283 52 , , , cord-015922-5wwy0m2k 283 53 4 4 CD cord-015922-5wwy0m2k 283 54 , , , cord-015922-5wwy0m2k 283 55 82 82 CD cord-015922-5wwy0m2k 283 56 ] ] -RRB- cord-015922-5wwy0m2k 283 57 . . . cord-015922-5wwy0m2k 284 1 Invasive invasive JJ cord-015922-5wwy0m2k 284 2 fungal fungal NN cord-015922-5wwy0m2k 284 3 disease disease NN cord-015922-5wwy0m2k 284 4 has have VBZ cord-015922-5wwy0m2k 284 5 been be VBN cord-015922-5wwy0m2k 284 6 most most RBS cord-015922-5wwy0m2k 284 7 commonly commonly RB cord-015922-5wwy0m2k 284 8 caused cause VBN cord-015922-5wwy0m2k 284 9 by by IN cord-015922-5wwy0m2k 284 10 Aspergillus aspergillus NN cord-015922-5wwy0m2k 284 11 sp sp NN cord-015922-5wwy0m2k 284 12 , , , cord-015922-5wwy0m2k 284 13 with with IN cord-015922-5wwy0m2k 284 14 A. a. NN cord-015922-5wwy0m2k 284 15 fumigatus fumigatus NNP cord-015922-5wwy0m2k 284 16 , , , cord-015922-5wwy0m2k 284 17 A. a. NN cord-015922-5wwy0m2k 284 18 flavus flavus NN cord-015922-5wwy0m2k 284 19 , , , cord-015922-5wwy0m2k 284 20 A. A. NNP cord-015922-5wwy0m2k 284 21 terreus terreus NNP cord-015922-5wwy0m2k 284 22 , , , cord-015922-5wwy0m2k 284 23 A. A. NNP cord-015922-5wwy0m2k 284 24 niger niger NNP cord-015922-5wwy0m2k 284 25 and and CC cord-015922-5wwy0m2k 284 26 A. A. NNP cord-015922-5wwy0m2k 284 27 nidulans nidulans NNP cord-015922-5wwy0m2k 284 28 being be VBG cord-015922-5wwy0m2k 284 29 the the DT cord-015922-5wwy0m2k 284 30 most most RBS cord-015922-5wwy0m2k 284 31 common common JJ cord-015922-5wwy0m2k 284 32 causes cause NNS cord-015922-5wwy0m2k 284 33 of of IN cord-015922-5wwy0m2k 284 34 invasive invasive JJ cord-015922-5wwy0m2k 284 35 aspergillosis aspergillosis NN cord-015922-5wwy0m2k 284 36 . . . cord-015922-5wwy0m2k 285 1 The the DT cord-015922-5wwy0m2k 285 2 portal portal NN cord-015922-5wwy0m2k 285 3 of of IN cord-015922-5wwy0m2k 285 4 entry entry NN cord-015922-5wwy0m2k 285 5 for for IN cord-015922-5wwy0m2k 285 6 90 90 CD cord-015922-5wwy0m2k 285 7 percent percent NN cord-015922-5wwy0m2k 285 8 of of IN cord-015922-5wwy0m2k 285 9 cases case NNS cord-015922-5wwy0m2k 285 10 of of IN cord-015922-5wwy0m2k 285 11 invasive invasive JJ cord-015922-5wwy0m2k 285 12 aspergillosis aspergillosis NN cord-015922-5wwy0m2k 285 13 is be VBZ cord-015922-5wwy0m2k 285 14 the the DT cord-015922-5wwy0m2k 285 15 lungs lung NNS cord-015922-5wwy0m2k 285 16 , , , cord-015922-5wwy0m2k 285 17 with with IN cord-015922-5wwy0m2k 285 18 the the DT cord-015922-5wwy0m2k 285 19 nasal nasal NN cord-015922-5wwy0m2k 285 20 sinuses sinus NNS cord-015922-5wwy0m2k 285 21 and and CC cord-015922-5wwy0m2k 285 22 the the DT cord-015922-5wwy0m2k 285 23 skin skin NN cord-015922-5wwy0m2k 285 24 accounting account VBG cord-015922-5wwy0m2k 285 25 for for IN cord-015922-5wwy0m2k 285 26 virtually virtually RB cord-015922-5wwy0m2k 285 27 all all DT cord-015922-5wwy0m2k 285 28 of of IN cord-015922-5wwy0m2k 285 29 the the DT cord-015922-5wwy0m2k 285 30 remaining remain VBG cord-015922-5wwy0m2k 285 31 cases case NNS cord-015922-5wwy0m2k 285 32 . . . cord-015922-5wwy0m2k 286 1 There there EX cord-015922-5wwy0m2k 286 2 are be VBP cord-015922-5wwy0m2k 286 3 two two CD cord-015922-5wwy0m2k 286 4 major major JJ cord-015922-5wwy0m2k 286 5 host host NN cord-015922-5wwy0m2k 286 6 defenses defense NNS cord-015922-5wwy0m2k 286 7 that that WDT cord-015922-5wwy0m2k 286 8 are be VBP cord-015922-5wwy0m2k 286 9 mobilized mobilize VBN cord-015922-5wwy0m2k 286 10 in in IN cord-015922-5wwy0m2k 286 11 response response NN cord-015922-5wwy0m2k 286 12 to to IN cord-015922-5wwy0m2k 286 13 inhalation inhalation NN cord-015922-5wwy0m2k 286 14 of of IN cord-015922-5wwy0m2k 286 15 the the DT cord-015922-5wwy0m2k 286 16 Aspergillus aspergillus NN cord-015922-5wwy0m2k 286 17 spores spore NNS cord-015922-5wwy0m2k 286 18 -granulocytes -granulocyte NNS cord-015922-5wwy0m2k 286 19 and and CC cord-015922-5wwy0m2k 286 20 cell cell NN cord-015922-5wwy0m2k 286 21 - - HYPH cord-015922-5wwy0m2k 286 22 mediated mediate VBN cord-015922-5wwy0m2k 286 23 immunity immunity NN cord-015922-5wwy0m2k 286 24 , , , cord-015922-5wwy0m2k 286 25 specifically specifically RB cord-015922-5wwy0m2k 286 26 cytotoxic cytotoxic JJ cord-015922-5wwy0m2k 286 27 T t NN cord-015922-5wwy0m2k 286 28 cells cell NNS cord-015922-5wwy0m2k 286 29 . . . cord-015922-5wwy0m2k 287 1 The the DT cord-015922-5wwy0m2k 287 2 importance importance NN cord-015922-5wwy0m2k 287 3 of of IN cord-015922-5wwy0m2k 287 4 these these DT cord-015922-5wwy0m2k 287 5 mechanisms mechanism NNS cord-015922-5wwy0m2k 287 6 is be VBZ cord-015922-5wwy0m2k 287 7 demonstrated demonstrate VBN cord-015922-5wwy0m2k 287 8 by by IN cord-015922-5wwy0m2k 287 9 the the DT cord-015922-5wwy0m2k 287 10 clustering clustering NN cord-015922-5wwy0m2k 287 11 of of IN cord-015922-5wwy0m2k 287 12 cases case NNS cord-015922-5wwy0m2k 287 13 of of IN cord-015922-5wwy0m2k 287 14 invasive invasive JJ cord-015922-5wwy0m2k 287 15 aspergillosis aspergillosis NN cord-015922-5wwy0m2k 287 16 at at IN cord-015922-5wwy0m2k 287 17 two two CD cord-015922-5wwy0m2k 287 18 timepoints timepoint NNS cord-015922-5wwy0m2k 287 19 in in IN cord-015922-5wwy0m2k 287 20 the the DT cord-015922-5wwy0m2k 287 21 posttransplant posttransplant NNP cord-015922-5wwy0m2k 287 22 course course NN cord-015922-5wwy0m2k 287 23 : : : cord-015922-5wwy0m2k 287 24 preengraftment preengraftment NNP cord-015922-5wwy0m2k 287 25 when when WRB cord-015922-5wwy0m2k 287 26 profound profound JJ cord-015922-5wwy0m2k 287 27 granulocytopenia granulocytopenia NNP cord-015922-5wwy0m2k 287 28 is be VBZ cord-015922-5wwy0m2k 287 29 present present JJ cord-015922-5wwy0m2k 287 30 , , , cord-015922-5wwy0m2k 287 31 with with IN cord-015922-5wwy0m2k 287 32 the the DT cord-015922-5wwy0m2k 287 33 incidence incidence NN cord-015922-5wwy0m2k 287 34 of of IN cord-015922-5wwy0m2k 287 35 invasive invasive JJ cord-015922-5wwy0m2k 287 36 aspergillosis aspergillosis NN cord-015922-5wwy0m2k 287 37 increasing increase VBG cord-015922-5wwy0m2k 287 38 steadily steadily RB cord-015922-5wwy0m2k 287 39 as as IN cord-015922-5wwy0m2k 287 40 the the DT cord-015922-5wwy0m2k 287 41 period period NN cord-015922-5wwy0m2k 287 42 of of IN cord-015922-5wwy0m2k 287 43 granulocytopenia granulocytopenia NNP cord-015922-5wwy0m2k 287 44 is be VBZ cord-015922-5wwy0m2k 287 45 extended extend VBN cord-015922-5wwy0m2k 287 46 , , , cord-015922-5wwy0m2k 287 47 and and CC cord-015922-5wwy0m2k 287 48 after after IN cord-015922-5wwy0m2k 287 49 the the DT cord-015922-5wwy0m2k 287 50 diagnosis diagnosis NN cord-015922-5wwy0m2k 287 51 of of IN cord-015922-5wwy0m2k 287 52 GVHD GVHD NNP cord-015922-5wwy0m2k 287 53 and and CC cord-015922-5wwy0m2k 287 54 the the DT cord-015922-5wwy0m2k 287 55 treatment treatment NN cord-015922-5wwy0m2k 287 56 of of IN cord-015922-5wwy0m2k 287 57 this this DT cord-015922-5wwy0m2k 287 58 adverse adverse JJ cord-015922-5wwy0m2k 287 59 event event NN cord-015922-5wwy0m2k 287 60 . . . cord-015922-5wwy0m2k 288 1 Indeed indeed RB cord-015922-5wwy0m2k 288 2 , , , cord-015922-5wwy0m2k 288 3 these these DT cord-015922-5wwy0m2k 288 4 late late JJ cord-015922-5wwy0m2k 288 5 cases case NNS cord-015922-5wwy0m2k 288 6 of of IN cord-015922-5wwy0m2k 288 7 invasive invasive JJ cord-015922-5wwy0m2k 288 8 aspergillosis aspergillosis NN cord-015922-5wwy0m2k 288 9 have have VBP cord-015922-5wwy0m2k 288 10 become become VBN cord-015922-5wwy0m2k 288 11 more more RBR cord-015922-5wwy0m2k 288 12 common common JJ cord-015922-5wwy0m2k 288 13 than than IN cord-015922-5wwy0m2k 288 14 the the DT cord-015922-5wwy0m2k 288 15 preengraftment preengraftment NN cord-015922-5wwy0m2k 288 16 cases case NNS cord-015922-5wwy0m2k 288 17 . . . cord-015922-5wwy0m2k 289 1 Mortality mortality NN cord-015922-5wwy0m2k 289 2 rates rate NNS cord-015922-5wwy0m2k 289 3 have have VBP cord-015922-5wwy0m2k 289 4 traditionally traditionally RB cord-015922-5wwy0m2k 289 5 been be VBN cord-015922-5wwy0m2k 289 6 high high JJ cord-015922-5wwy0m2k 289 7 in in IN cord-015922-5wwy0m2k 289 8 patients patient NNS cord-015922-5wwy0m2k 289 9 who who WP cord-015922-5wwy0m2k 289 10 developed develop VBD cord-015922-5wwy0m2k 289 11 invasive invasive JJ cord-015922-5wwy0m2k 289 12 aspergillosis aspergillosis NN cord-015922-5wwy0m2k 289 13 in in IN cord-015922-5wwy0m2k 289 14 either either DT cord-015922-5wwy0m2k 289 15 time time NN cord-015922-5wwy0m2k 289 16 period period NN cord-015922-5wwy0m2k 289 17 [ [ -LRB- cord-015922-5wwy0m2k 289 18 1 1 CD cord-015922-5wwy0m2k 289 19 , , , cord-015922-5wwy0m2k 289 20 4 4 CD cord-015922-5wwy0m2k 289 21 , , , cord-015922-5wwy0m2k 289 22 92 92 CD cord-015922-5wwy0m2k 289 23 , , , cord-015922-5wwy0m2k 289 24 93 93 CD cord-015922-5wwy0m2k 289 25 ] ] -RRB- cord-015922-5wwy0m2k 289 26 . . . cord-015922-5wwy0m2k 290 1 The the DT cord-015922-5wwy0m2k 290 2 clinical clinical JJ cord-015922-5wwy0m2k 290 3 syndromes syndrome NNS cord-015922-5wwy0m2k 290 4 caused cause VBN cord-015922-5wwy0m2k 290 5 by by IN cord-015922-5wwy0m2k 290 6 Aspergillus aspergillus NN cord-015922-5wwy0m2k 290 7 invasion invasion NN cord-015922-5wwy0m2k 290 8 reflect reflect VBP cord-015922-5wwy0m2k 290 9 the the DT cord-015922-5wwy0m2k 290 10 pathologic pathologic JJ cord-015922-5wwy0m2k 290 11 consequences consequence NNS cord-015922-5wwy0m2k 290 12 of of IN cord-015922-5wwy0m2k 290 13 the the DT cord-015922-5wwy0m2k 290 14 vasculotropic vasculotropic JJ cord-015922-5wwy0m2k 290 15 nature nature NN cord-015922-5wwy0m2k 290 16 of of IN cord-015922-5wwy0m2k 290 17 this this DT cord-015922-5wwy0m2k 290 18 mold mold NN cord-015922-5wwy0m2k 290 19 . . . cord-015922-5wwy0m2k 291 1 The the DT cord-015922-5wwy0m2k 291 2 three three CD cord-015922-5wwy0m2k 291 3 major major JJ cord-015922-5wwy0m2k 291 4 consequences consequence NNS cord-015922-5wwy0m2k 291 5 of of IN cord-015922-5wwy0m2k 291 6 the the DT cord-015922-5wwy0m2k 291 7 vascular vascular JJ cord-015922-5wwy0m2k 291 8 invasion invasion NN cord-015922-5wwy0m2k 291 9 that that WDT cord-015922-5wwy0m2k 291 10 characterizes characterize VBZ cord-015922-5wwy0m2k 291 11 Aspergillus aspergillus NN cord-015922-5wwy0m2k 291 12 invasion invasion NN cord-015922-5wwy0m2k 291 13 include include VBP cord-015922-5wwy0m2k 291 14 hemorrhage hemorrhage NN cord-015922-5wwy0m2k 291 15 , , , cord-015922-5wwy0m2k 291 16 infarction infarction NN cord-015922-5wwy0m2k 291 17 and and CC cord-015922-5wwy0m2k 291 18 metastatic metastatic JJ cord-015922-5wwy0m2k 291 19 disease disease NN cord-015922-5wwy0m2k 291 20 . . . cord-015922-5wwy0m2k 292 1 Initial initial JJ cord-015922-5wwy0m2k 292 2 clinical clinical JJ cord-015922-5wwy0m2k 292 3 complaints complaint NNS cord-015922-5wwy0m2k 292 4 include include VBP cord-015922-5wwy0m2k 292 5 persistent persistent JJ cord-015922-5wwy0m2k 292 6 fever fever NN cord-015922-5wwy0m2k 292 7 , , , cord-015922-5wwy0m2k 292 8 chest chest NN cord-015922-5wwy0m2k 292 9 pain pain NN cord-015922-5wwy0m2k 292 10 , , , cord-015922-5wwy0m2k 292 11 tachypnea tachypnea NNP cord-015922-5wwy0m2k 292 12 , , , cord-015922-5wwy0m2k 292 13 hypoxemia hypoxemia NN cord-015922-5wwy0m2k 292 14 and and CC cord-015922-5wwy0m2k 292 15 hemoptysis hemoptysis NN cord-015922-5wwy0m2k 292 16 , , , cord-015922-5wwy0m2k 292 17 as as RB cord-015922-5wwy0m2k 292 18 well well RB cord-015922-5wwy0m2k 292 19 as as IN cord-015922-5wwy0m2k 292 20 symptoms symptom NNS cord-015922-5wwy0m2k 292 21 related relate VBN cord-015922-5wwy0m2k 292 22 to to IN cord-015922-5wwy0m2k 292 23 metastases metastasis NNS cord-015922-5wwy0m2k 292 24 . . . cord-015922-5wwy0m2k 293 1 Before before IN cord-015922-5wwy0m2k 293 2 the the DT cord-015922-5wwy0m2k 293 3 availability availability NN cord-015922-5wwy0m2k 293 4 of of IN cord-015922-5wwy0m2k 293 5 noninvasive noninvasive JJ cord-015922-5wwy0m2k 293 6 fungal fungal JJ cord-015922-5wwy0m2k 293 7 markers marker NNS cord-015922-5wwy0m2k 293 8 ( ( -LRB- cord-015922-5wwy0m2k 293 9 galactomannan galactomannan NNP cord-015922-5wwy0m2k 293 10 and and CC cord-015922-5wwy0m2k 293 11 β β NN cord-015922-5wwy0m2k 293 12 - - HYPH cord-015922-5wwy0m2k 293 13 glucan glucan NNP cord-015922-5wwy0m2k 293 14 ) ) -RRB- cord-015922-5wwy0m2k 293 15 and and CC cord-015922-5wwy0m2k 293 16 aggressive aggressive JJ cord-015922-5wwy0m2k 293 17 imaging imaging NN cord-015922-5wwy0m2k 293 18 with with IN cord-015922-5wwy0m2k 293 19 spiral spiral JJ cord-015922-5wwy0m2k 293 20 chest chest NN cord-015922-5wwy0m2k 293 21 computerized computerized NN cord-015922-5wwy0m2k 293 22 tomographic tomographic NN cord-015922-5wwy0m2k 293 23 ( ( -LRB- cord-015922-5wwy0m2k 293 24 CT CT NNP cord-015922-5wwy0m2k 293 25 ) ) -RRB- cord-015922-5wwy0m2k 293 26 scanning scanning NN cord-015922-5wwy0m2k 293 27 , , , cord-015922-5wwy0m2k 293 28 50 50 CD cord-015922-5wwy0m2k 293 29 percent percent NN cord-015922-5wwy0m2k 293 30 or or CC cord-015922-5wwy0m2k 293 31 more more JJR cord-015922-5wwy0m2k 293 32 of of IN cord-015922-5wwy0m2k 293 33 patients patient NNS cord-015922-5wwy0m2k 293 34 experience experience NN cord-015922-5wwy0m2k 293 35 disseminated disseminate VBN cord-015922-5wwy0m2k 293 36 infection infection NN cord-015922-5wwy0m2k 293 37 at at IN cord-015922-5wwy0m2k 293 38 the the DT cord-015922-5wwy0m2k 293 39 time time NN cord-015922-5wwy0m2k 293 40 of of IN cord-015922-5wwy0m2k 293 41 first first JJ cord-015922-5wwy0m2k 293 42 diagnosis diagnosis NN cord-015922-5wwy0m2k 293 43 , , , cord-015922-5wwy0m2k 293 44 accounting account VBG cord-015922-5wwy0m2k 293 45 for for IN cord-015922-5wwy0m2k 293 46 the the DT cord-015922-5wwy0m2k 293 47 high high JJ cord-015922-5wwy0m2k 293 48 mortality mortality NN cord-015922-5wwy0m2k 293 49 observed observe VBN cord-015922-5wwy0m2k 293 50 in in IN cord-015922-5wwy0m2k 293 51 allogeneic allogeneic JJ cord-015922-5wwy0m2k 293 52 HSCT HSCT NNP cord-015922-5wwy0m2k 293 53 recipients recipient NNS cord-015922-5wwy0m2k 293 54 . . . cord-015922-5wwy0m2k 294 1 A a DT cord-015922-5wwy0m2k 294 2 particular particular JJ cord-015922-5wwy0m2k 294 3 problem problem NN cord-015922-5wwy0m2k 294 4 is be VBZ cord-015922-5wwy0m2k 294 5 infection infection NN cord-015922-5wwy0m2k 294 6 in in IN cord-015922-5wwy0m2k 294 7 the the DT cord-015922-5wwy0m2k 294 8 CNS CNS NNP cord-015922-5wwy0m2k 294 9 , , , cord-015922-5wwy0m2k 294 10 where where WRB cord-015922-5wwy0m2k 294 11 mortality mortality NN cord-015922-5wwy0m2k 294 12 historically historically RB cord-015922-5wwy0m2k 294 13 has have VBZ cord-015922-5wwy0m2k 294 14 approached approach VBN cord-015922-5wwy0m2k 294 15 100 100 CD cord-015922-5wwy0m2k 294 16 percent percent NN cord-015922-5wwy0m2k 294 17 . . . cord-015922-5wwy0m2k 295 1 Metastases Metastases NNP cord-015922-5wwy0m2k 295 2 can can MD cord-015922-5wwy0m2k 295 3 present present VB cord-015922-5wwy0m2k 295 4 any any DT cord-015922-5wwy0m2k 295 5 site site NN cord-015922-5wwy0m2k 295 6 , , , cord-015922-5wwy0m2k 295 7 but but CC cord-015922-5wwy0m2k 295 8 particularly particularly RB cord-015922-5wwy0m2k 295 9 important important JJ cord-015922-5wwy0m2k 295 10 is be VBZ cord-015922-5wwy0m2k 295 11 the the DT cord-015922-5wwy0m2k 295 12 skin skin NN cord-015922-5wwy0m2k 295 13 , , , cord-015922-5wwy0m2k 295 14 as as IN cord-015922-5wwy0m2k 295 15 innocent innocent JJ cord-015922-5wwy0m2k 295 16 appearing appear VBG cord-015922-5wwy0m2k 295 17 skin skin NN cord-015922-5wwy0m2k 295 18 lesions lesion NNS cord-015922-5wwy0m2k 295 19 can can MD cord-015922-5wwy0m2k 295 20 lead lead VB cord-015922-5wwy0m2k 295 21 to to IN cord-015922-5wwy0m2k 295 22 early early JJ cord-015922-5wwy0m2k 295 23 recognition recognition NN cord-015922-5wwy0m2k 295 24 of of IN cord-015922-5wwy0m2k 295 25 the the DT cord-015922-5wwy0m2k 295 26 disease disease NN cord-015922-5wwy0m2k 295 27 , , , cord-015922-5wwy0m2k 295 28 and and CC cord-015922-5wwy0m2k 295 29 should should MD cord-015922-5wwy0m2k 295 30 be be VB cord-015922-5wwy0m2k 295 31 aggressively aggressively RB cord-015922-5wwy0m2k 295 32 biopsied biopsie VBN cord-015922-5wwy0m2k 295 33 [ [ -LRB- cord-015922-5wwy0m2k 295 34 4 4 CD cord-015922-5wwy0m2k 295 35 ] ] -RRB- cord-015922-5wwy0m2k 295 36 . . . cord-015922-5wwy0m2k 296 1 Definitive definitive JJ cord-015922-5wwy0m2k 296 2 diagnosis diagnosis NN cord-015922-5wwy0m2k 296 3 of of IN cord-015922-5wwy0m2k 296 4 invasive invasive JJ cord-015922-5wwy0m2k 296 5 mold mold NN cord-015922-5wwy0m2k 296 6 infections infection NNS cord-015922-5wwy0m2k 296 7 , , , cord-015922-5wwy0m2k 296 8 including include VBG cord-015922-5wwy0m2k 296 9 invasive invasive JJ cord-015922-5wwy0m2k 296 10 aspergillosis aspergillosis NN cord-015922-5wwy0m2k 296 11 , , , cord-015922-5wwy0m2k 296 12 is be VBZ cord-015922-5wwy0m2k 296 13 usually usually RB cord-015922-5wwy0m2k 296 14 accomplished accomplish VBN cord-015922-5wwy0m2k 296 15 by by IN cord-015922-5wwy0m2k 296 16 biopsying biopsye VBG cord-015922-5wwy0m2k 296 17 the the DT cord-015922-5wwy0m2k 296 18 site site NN cord-015922-5wwy0m2k 296 19 of of IN cord-015922-5wwy0m2k 296 20 abnormality abnormality NN cord-015922-5wwy0m2k 296 21 . . . cord-015922-5wwy0m2k 297 1 Early early JJ cord-015922-5wwy0m2k 297 2 diagnosis diagnosis NN cord-015922-5wwy0m2k 297 3 is be VBZ cord-015922-5wwy0m2k 297 4 the the DT cord-015922-5wwy0m2k 297 5 key key NN cord-015922-5wwy0m2k 297 6 to to IN cord-015922-5wwy0m2k 297 7 effective effective JJ cord-015922-5wwy0m2k 297 8 therapy therapy NN cord-015922-5wwy0m2k 297 9 [ [ -LRB- cord-015922-5wwy0m2k 297 10 94 94 CD cord-015922-5wwy0m2k 297 11 ] ] -RRB- cord-015922-5wwy0m2k 297 12 . . . cord-015922-5wwy0m2k 298 1 Sputum Sputum NNP cord-015922-5wwy0m2k 298 2 or or CC cord-015922-5wwy0m2k 298 3 bronchoscopic bronchoscopic NN cord-015922-5wwy0m2k 298 4 samples sample NNS cord-015922-5wwy0m2k 298 5 rarely rarely RB cord-015922-5wwy0m2k 298 6 yield yield VBP cord-015922-5wwy0m2k 298 7 mold mold NN cord-015922-5wwy0m2k 298 8 on on IN cord-015922-5wwy0m2k 298 9 culture culture NN cord-015922-5wwy0m2k 298 10 . . . cord-015922-5wwy0m2k 299 1 In in IN cord-015922-5wwy0m2k 299 2 recent recent JJ cord-015922-5wwy0m2k 299 3 years year NNS cord-015922-5wwy0m2k 299 4 , , , cord-015922-5wwy0m2k 299 5 considerable considerable JJ cord-015922-5wwy0m2k 299 6 effort effort NN cord-015922-5wwy0m2k 299 7 has have VBZ cord-015922-5wwy0m2k 299 8 been be VBN cord-015922-5wwy0m2k 299 9 made make VBN cord-015922-5wwy0m2k 299 10 to to TO cord-015922-5wwy0m2k 299 11 find find VB cord-015922-5wwy0m2k 299 12 other other JJ cord-015922-5wwy0m2k 299 13 technology technology NN cord-015922-5wwy0m2k 299 14 that that WDT cord-015922-5wwy0m2k 299 15 will will MD cord-015922-5wwy0m2k 299 16 lead lead VB cord-015922-5wwy0m2k 299 17 to to IN cord-015922-5wwy0m2k 299 18 an an DT cord-015922-5wwy0m2k 299 19 earlier early JJR cord-015922-5wwy0m2k 299 20 and and CC cord-015922-5wwy0m2k 299 21 timely timely JJ cord-015922-5wwy0m2k 299 22 diagnosis diagnosis NN cord-015922-5wwy0m2k 299 23 . . . cord-015922-5wwy0m2k 300 1 The the DT cord-015922-5wwy0m2k 300 2 ones one NNS cord-015922-5wwy0m2k 300 3 that that WDT cord-015922-5wwy0m2k 300 4 have have VBP cord-015922-5wwy0m2k 300 5 been be VBN cord-015922-5wwy0m2k 300 6 incorporated incorporate VBN cord-015922-5wwy0m2k 300 7 into into IN cord-015922-5wwy0m2k 300 8 practice practice NN cord-015922-5wwy0m2k 300 9 are be VBP cord-015922-5wwy0m2k 300 10 the the DT cord-015922-5wwy0m2k 300 11 systematic systematic JJ cord-015922-5wwy0m2k 300 12 measurement measurement NN cord-015922-5wwy0m2k 300 13 of of IN cord-015922-5wwy0m2k 300 14 Aspergillus aspergillus NN cord-015922-5wwy0m2k 300 15 antigens antigen NNS cord-015922-5wwy0m2k 300 16 and and CC cord-015922-5wwy0m2k 300 17 serial serial JJ cord-015922-5wwy0m2k 300 18 chest chest NN cord-015922-5wwy0m2k 300 19 CT CT NNP cord-015922-5wwy0m2k 300 20 imaging imaging NN cord-015922-5wwy0m2k 300 21 . . . cord-015922-5wwy0m2k 301 1 Monitoring monitor VBG cord-015922-5wwy0m2k 301 2 the the DT cord-015922-5wwy0m2k 301 3 serum serum NN cord-015922-5wwy0m2k 301 4 of of IN cord-015922-5wwy0m2k 301 5 HSCT HSCT NNP cord-015922-5wwy0m2k 301 6 patients patient NNS cord-015922-5wwy0m2k 301 7 for for IN cord-015922-5wwy0m2k 301 8 galactomannan galactomannan NNP cord-015922-5wwy0m2k 301 9 or or CC cord-015922-5wwy0m2k 301 10 β β NN cord-015922-5wwy0m2k 301 11 - - HYPH cord-015922-5wwy0m2k 301 12 glucan glucan NN cord-015922-5wwy0m2k 301 13 is be VBZ cord-015922-5wwy0m2k 301 14 now now RB cord-015922-5wwy0m2k 301 15 commercially commercially RB cord-015922-5wwy0m2k 301 16 available available JJ cord-015922-5wwy0m2k 301 17 and and CC cord-015922-5wwy0m2k 301 18 has have VBZ cord-015922-5wwy0m2k 301 19 been be VBN cord-015922-5wwy0m2k 301 20 incorporated incorporate VBN cord-015922-5wwy0m2k 301 21 into into IN cord-015922-5wwy0m2k 301 22 the the DT cord-015922-5wwy0m2k 301 23 current current JJ cord-015922-5wwy0m2k 301 24 diagnosis diagnosis NN cord-015922-5wwy0m2k 301 25 guidelines guideline NNS cord-015922-5wwy0m2k 301 26 [ [ -LRB- cord-015922-5wwy0m2k 301 27 95 95 CD cord-015922-5wwy0m2k 301 28 , , , cord-015922-5wwy0m2k 301 29 96 96 CD cord-015922-5wwy0m2k 301 30 ] ] -RRB- cord-015922-5wwy0m2k 301 31 . . . cord-015922-5wwy0m2k 302 1 The the DT cord-015922-5wwy0m2k 302 2 detection detection NN cord-015922-5wwy0m2k 302 3 of of IN cord-015922-5wwy0m2k 302 4 circulating circulate VBG cord-015922-5wwy0m2k 302 5 fungal fungal JJ cord-015922-5wwy0m2k 302 6 DNA dna NN cord-015922-5wwy0m2k 302 7 in in IN cord-015922-5wwy0m2k 302 8 the the DT cord-015922-5wwy0m2k 302 9 blood blood NN cord-015922-5wwy0m2k 302 10 by by IN cord-015922-5wwy0m2k 302 11 PCR PCR NNP cord-015922-5wwy0m2k 302 12 [ [ -LRB- cord-015922-5wwy0m2k 302 13 97 97 CD cord-015922-5wwy0m2k 302 14 ] ] -RRB- cord-015922-5wwy0m2k 302 15 remains remain VBZ cord-015922-5wwy0m2k 302 16 experimental experimental JJ cord-015922-5wwy0m2k 302 17 . . . cord-015922-5wwy0m2k 303 1 Findings finding NNS cord-015922-5wwy0m2k 303 2 on on IN cord-015922-5wwy0m2k 303 3 chest chest NN cord-015922-5wwy0m2k 303 4 CT CT NNP cord-015922-5wwy0m2k 303 5 , , , cord-015922-5wwy0m2k 303 6 in in IN cord-015922-5wwy0m2k 303 7 particular particular JJ cord-015922-5wwy0m2k 303 8 the the DT cord-015922-5wwy0m2k 303 9 halo halo NN cord-015922-5wwy0m2k 303 10 sign sign NN cord-015922-5wwy0m2k 303 11 ( ( -LRB- cord-015922-5wwy0m2k 303 12 Fig Fig NNP cord-015922-5wwy0m2k 303 13 . . . cord-015922-5wwy0m2k 303 14 _SP cord-015922-5wwy0m2k 303 15 19 19 CD cord-015922-5wwy0m2k 303 16 - - SYM cord-015922-5wwy0m2k 303 17 2 2 CD cord-015922-5wwy0m2k 303 18 ) ) -RRB- cord-015922-5wwy0m2k 303 19 , , , cord-015922-5wwy0m2k 303 20 are be VBP cord-015922-5wwy0m2k 303 21 associated associate VBN cord-015922-5wwy0m2k 303 22 in in IN cord-015922-5wwy0m2k 303 23 the the DT cord-015922-5wwy0m2k 303 24 neutropenic neutropenic JJ cord-015922-5wwy0m2k 303 25 patient patient JJ cord-015922-5wwy0m2k 303 26 with with IN cord-015922-5wwy0m2k 303 27 invasive invasive JJ cord-015922-5wwy0m2k 303 28 aspergillosis aspergillosis NN cord-015922-5wwy0m2k 303 29 ( ( -LRB- cord-015922-5wwy0m2k 303 30 although although IN cord-015922-5wwy0m2k 303 31 other other JJ cord-015922-5wwy0m2k 303 32 pathogens pathogen NNS cord-015922-5wwy0m2k 303 33 can can MD cord-015922-5wwy0m2k 303 34 cause cause VB cord-015922-5wwy0m2k 303 35 the the DT cord-015922-5wwy0m2k 303 36 same same JJ cord-015922-5wwy0m2k 303 37 radiologic radiologic JJ cord-015922-5wwy0m2k 303 38 finding finding NN cord-015922-5wwy0m2k 303 39 : : : cord-015922-5wwy0m2k 303 40 Fusarium fusarium NN cord-015922-5wwy0m2k 303 41 and and CC cord-015922-5wwy0m2k 303 42 other other JJ cord-015922-5wwy0m2k 303 43 vasculotrophic vasculotrophic JJ cord-015922-5wwy0m2k 303 44 molds mold NNS cord-015922-5wwy0m2k 303 45 and and CC cord-015922-5wwy0m2k 303 46 Nocardia Nocardia NNP cord-015922-5wwy0m2k 303 47 asteroides asteroides NNP cord-015922-5wwy0m2k 303 48 being be VBG cord-015922-5wwy0m2k 303 49 examples example NNS cord-015922-5wwy0m2k 303 50 of of IN cord-015922-5wwy0m2k 303 51 this this DT cord-015922-5wwy0m2k 303 52 ) ) -RRB- cord-015922-5wwy0m2k 303 53 . . . cord-015922-5wwy0m2k 304 1 European european JJ cord-015922-5wwy0m2k 304 2 groups group NNS cord-015922-5wwy0m2k 304 3 have have VBP cord-015922-5wwy0m2k 304 4 been be VBN cord-015922-5wwy0m2k 304 5 advocating advocate VBG cord-015922-5wwy0m2k 304 6 protocol protocol NN cord-015922-5wwy0m2k 304 7 serial serial JJ cord-015922-5wwy0m2k 304 8 chest chest NN cord-015922-5wwy0m2k 304 9 CT CT NNP cord-015922-5wwy0m2k 304 10 scans scan NNS cord-015922-5wwy0m2k 304 11 to to TO cord-015922-5wwy0m2k 304 12 find find VB cord-015922-5wwy0m2k 304 13 such such JJ cord-015922-5wwy0m2k 304 14 pathology pathology NN cord-015922-5wwy0m2k 304 15 as as IN cord-015922-5wwy0m2k 304 16 a a DT cord-015922-5wwy0m2k 304 17 guide guide NN cord-015922-5wwy0m2k 304 18 to to IN cord-015922-5wwy0m2k 304 19 early early JJ cord-015922-5wwy0m2k 304 20 diagnosis diagnosis NN cord-015922-5wwy0m2k 304 21 [ [ -LRB- cord-015922-5wwy0m2k 304 22 98 98 CD cord-015922-5wwy0m2k 304 23 ] ] -RRB- cord-015922-5wwy0m2k 304 24 . . . cord-015922-5wwy0m2k 305 1 If if IN cord-015922-5wwy0m2k 305 2 prevention prevention NN cord-015922-5wwy0m2k 305 3 fails fail VBZ cord-015922-5wwy0m2k 305 4 , , , cord-015922-5wwy0m2k 305 5 then then RB cord-015922-5wwy0m2k 305 6 early early JJ cord-015922-5wwy0m2k 305 7 diagnosis diagnosis NN cord-015922-5wwy0m2k 305 8 is be VBZ cord-015922-5wwy0m2k 305 9 the the DT cord-015922-5wwy0m2k 305 10 key key NN cord-015922-5wwy0m2k 305 11 to to IN cord-015922-5wwy0m2k 305 12 the the DT cord-015922-5wwy0m2k 305 13 patient patient NN cord-015922-5wwy0m2k 305 14 's 's POS cord-015922-5wwy0m2k 305 15 survival survival NN cord-015922-5wwy0m2k 305 16 [ [ -LRB- cord-015922-5wwy0m2k 305 17 4 4 CD cord-015922-5wwy0m2k 305 18 , , , cord-015922-5wwy0m2k 305 19 92 92 CD cord-015922-5wwy0m2k 305 20 , , , cord-015922-5wwy0m2k 305 21 93 93 CD cord-015922-5wwy0m2k 305 22 ] ] -RRB- cord-015922-5wwy0m2k 305 23 . . . cord-015922-5wwy0m2k 306 1 Given give VBN cord-015922-5wwy0m2k 306 2 the the DT cord-015922-5wwy0m2k 306 3 limitations limitation NNS cord-015922-5wwy0m2k 306 4 of of IN cord-015922-5wwy0m2k 306 5 current current JJ cord-015922-5wwy0m2k 306 6 diagnostic diagnostic JJ cord-015922-5wwy0m2k 306 7 techniques technique NNS cord-015922-5wwy0m2k 306 8 and and CC cord-015922-5wwy0m2k 306 9 the the DT cord-015922-5wwy0m2k 306 10 significant significant JJ cord-015922-5wwy0m2k 306 11 morbidity morbidity NN cord-015922-5wwy0m2k 306 12 associated associate VBN cord-015922-5wwy0m2k 306 13 with with IN cord-015922-5wwy0m2k 306 14 invasive invasive JJ cord-015922-5wwy0m2k 306 15 fungal fungal JJ cord-015922-5wwy0m2k 306 16 infection infection NN cord-015922-5wwy0m2k 306 17 , , , cord-015922-5wwy0m2k 306 18 two two CD cord-015922-5wwy0m2k 306 19 strategies strategy NNS cord-015922-5wwy0m2k 306 20 of of IN cord-015922-5wwy0m2k 306 21 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 306 22 use use NN cord-015922-5wwy0m2k 306 23 are be VBP cord-015922-5wwy0m2k 306 24 commonly commonly RB cord-015922-5wwy0m2k 306 25 deployed deploy VBN cord-015922-5wwy0m2k 306 26 in in IN cord-015922-5wwy0m2k 306 27 the the DT cord-015922-5wwy0m2k 306 28 HSCT HSCT NNP cord-015922-5wwy0m2k 306 29 patient patient NN cord-015922-5wwy0m2k 306 30 . . . cord-015922-5wwy0m2k 307 1 The the DT cord-015922-5wwy0m2k 307 2 first first JJ cord-015922-5wwy0m2k 307 3 is be VBZ cord-015922-5wwy0m2k 307 4 prophylactic prophylactic JJ cord-015922-5wwy0m2k 307 5 fluconazole fluconazole NN cord-015922-5wwy0m2k 307 6 use use NN cord-015922-5wwy0m2k 307 7 during during IN cord-015922-5wwy0m2k 307 8 the the DT cord-015922-5wwy0m2k 307 9 initial initial JJ cord-015922-5wwy0m2k 307 10 transplant transplant NN cord-015922-5wwy0m2k 307 11 period period NN cord-015922-5wwy0m2k 307 12 , , , cord-015922-5wwy0m2k 307 13 which which WDT cord-015922-5wwy0m2k 307 14 has have VBZ cord-015922-5wwy0m2k 307 15 been be VBN cord-015922-5wwy0m2k 307 16 shown show VBN cord-015922-5wwy0m2k 307 17 to to TO cord-015922-5wwy0m2k 307 18 decrease decrease VB cord-015922-5wwy0m2k 307 19 fungal fungal JJ cord-015922-5wwy0m2k 307 20 infections infection NNS cord-015922-5wwy0m2k 307 21 [ [ -LRB- cord-015922-5wwy0m2k 307 22 80 80 CD cord-015922-5wwy0m2k 307 23 ] ] -RRB- cord-015922-5wwy0m2k 307 24 in in IN cord-015922-5wwy0m2k 307 25 one one CD cord-015922-5wwy0m2k 307 26 study study NN cord-015922-5wwy0m2k 307 27 , , , cord-015922-5wwy0m2k 307 28 and and CC cord-015922-5wwy0m2k 307 29 overall overall JJ cord-015922-5wwy0m2k 307 30 mortality mortality NN cord-015922-5wwy0m2k 307 31 Fig Fig NNP cord-015922-5wwy0m2k 307 32 . . . cord-015922-5wwy0m2k 308 1 19 19 CD cord-015922-5wwy0m2k 308 2 - - SYM cord-015922-5wwy0m2k 308 3 2 2 CD cord-015922-5wwy0m2k 308 4 . . . cord-015922-5wwy0m2k 309 1 Computerized computerize VBN cord-015922-5wwy0m2k 309 2 tomographic tomographic JJ cord-015922-5wwy0m2k 309 3 scan scan NN cord-015922-5wwy0m2k 309 4 of of IN cord-015922-5wwy0m2k 309 5 the the DT cord-015922-5wwy0m2k 309 6 chest chest NN cord-015922-5wwy0m2k 309 7 in in IN cord-015922-5wwy0m2k 309 8 a a DT cord-015922-5wwy0m2k 309 9 patient patient NN cord-015922-5wwy0m2k 309 10 with with IN cord-015922-5wwy0m2k 309 11 a a DT cord-015922-5wwy0m2k 309 12 " " `` cord-015922-5wwy0m2k 309 13 halo halo NN cord-015922-5wwy0m2k 309 14 sign sign NN cord-015922-5wwy0m2k 309 15 " " '' cord-015922-5wwy0m2k 309 16 due due JJ cord-015922-5wwy0m2k 309 17 to to IN cord-015922-5wwy0m2k 309 18 invasive invasive JJ cord-015922-5wwy0m2k 309 19 aspergillosis aspergillosis NN cord-015922-5wwy0m2k 309 20 . . . cord-015922-5wwy0m2k 310 1 Note note VB cord-015922-5wwy0m2k 310 2 that that IN cord-015922-5wwy0m2k 310 3 halo halo NN cord-015922-5wwy0m2k 310 4 signs sign NNS cord-015922-5wwy0m2k 310 5 most most RBS cord-015922-5wwy0m2k 310 6 commonly commonly RB cord-015922-5wwy0m2k 310 7 occur occur VBP cord-015922-5wwy0m2k 310 8 in in IN cord-015922-5wwy0m2k 310 9 granulocytopenic granulocytopenic NN cord-015922-5wwy0m2k 310 10 HSCT HSCT NNP cord-015922-5wwy0m2k 310 11 recipients recipient NNS cord-015922-5wwy0m2k 310 12 with with IN cord-015922-5wwy0m2k 310 13 invasive invasive JJ cord-015922-5wwy0m2k 310 14 aspergillosis aspergillosis NN cord-015922-5wwy0m2k 310 15 . . . cord-015922-5wwy0m2k 311 1 However however RB cord-015922-5wwy0m2k 311 2 , , , cord-015922-5wwy0m2k 311 3 it -PRON- PRP cord-015922-5wwy0m2k 311 4 must must MD cord-015922-5wwy0m2k 311 5 be be VB cord-015922-5wwy0m2k 311 6 emphasized emphasize VBN cord-015922-5wwy0m2k 311 7 that that IN cord-015922-5wwy0m2k 311 8 a a DT cord-015922-5wwy0m2k 311 9 halo halo NN cord-015922-5wwy0m2k 311 10 sign sign NN cord-015922-5wwy0m2k 311 11 is be VBZ cord-015922-5wwy0m2k 311 12 occasionally occasionally RB cord-015922-5wwy0m2k 311 13 seen see VBN cord-015922-5wwy0m2k 311 14 in in IN cord-015922-5wwy0m2k 311 15 patients patient NNS cord-015922-5wwy0m2k 311 16 with with IN cord-015922-5wwy0m2k 311 17 Nocardia Nocardia NNP cord-015922-5wwy0m2k 311 18 , , , cord-015922-5wwy0m2k 311 19 Scedosporium Scedosporium NNP cord-015922-5wwy0m2k 311 20 , , , cord-015922-5wwy0m2k 311 21 Fusarium fusarium NN cord-015922-5wwy0m2k 311 22 and and CC cord-015922-5wwy0m2k 311 23 other other JJ cord-015922-5wwy0m2k 311 24 forms form NNS cord-015922-5wwy0m2k 311 25 of of IN cord-015922-5wwy0m2k 311 26 pneumonia pneumonia NN cord-015922-5wwy0m2k 311 27 . . . cord-015922-5wwy0m2k 312 1 The the DT cord-015922-5wwy0m2k 312 2 patient patient NN cord-015922-5wwy0m2k 312 3 was be VBD cord-015922-5wwy0m2k 312 4 treated treat VBN cord-015922-5wwy0m2k 312 5 with with IN cord-015922-5wwy0m2k 312 6 voriconazole voriconazole NN cord-015922-5wwy0m2k 312 7 monotherapy monotherapy JJ cord-015922-5wwy0m2k 312 8 during during IN cord-015922-5wwy0m2k 312 9 neutropenia neutropenia NN cord-015922-5wwy0m2k 312 10 during during IN cord-015922-5wwy0m2k 312 11 consolidation consolidation NN cord-015922-5wwy0m2k 312 12 chemotherapy chemotherapy NN cord-015922-5wwy0m2k 312 13 for for IN cord-015922-5wwy0m2k 312 14 AML AML NNP cord-015922-5wwy0m2k 312 15 and and CC cord-015922-5wwy0m2k 312 16 his -PRON- PRP$ cord-015922-5wwy0m2k 312 17 treatment treatment NN cord-015922-5wwy0m2k 312 18 was be VBD cord-015922-5wwy0m2k 312 19 continued continue VBN cord-015922-5wwy0m2k 312 20 through through IN cord-015922-5wwy0m2k 312 21 allogeneic allogeneic NN cord-015922-5wwy0m2k 312 22 transplantation transplantation NN cord-015922-5wwy0m2k 312 23 . . . cord-015922-5wwy0m2k 313 1 [ [ -LRB- cord-015922-5wwy0m2k 313 2 79 79 CD cord-015922-5wwy0m2k 313 3 ] ] -RRB- cord-015922-5wwy0m2k 313 4 in in IN cord-015922-5wwy0m2k 313 5 another another DT cord-015922-5wwy0m2k 313 6 , , , cord-015922-5wwy0m2k 313 7 when when WRB cord-015922-5wwy0m2k 313 8 started start VBN cord-015922-5wwy0m2k 313 9 on on IN cord-015922-5wwy0m2k 313 10 day day NN cord-015922-5wwy0m2k 313 11 0 0 CD cord-015922-5wwy0m2k 313 12 until until IN cord-015922-5wwy0m2k 313 13 engraftment engraftment NN cord-015922-5wwy0m2k 313 14 [ [ -LRB- cord-015922-5wwy0m2k 313 15 80 80 CD cord-015922-5wwy0m2k 313 16 ] ] -RRB- cord-015922-5wwy0m2k 313 17 or or CC cord-015922-5wwy0m2k 313 18 day day NN cord-015922-5wwy0m2k 313 19 +75 +75 XX cord-015922-5wwy0m2k 313 20 [ [ -LRB- cord-015922-5wwy0m2k 313 21 79 79 CD cord-015922-5wwy0m2k 313 22 ] ] -RRB- cord-015922-5wwy0m2k 313 23 . . . cord-015922-5wwy0m2k 314 1 It -PRON- PRP cord-015922-5wwy0m2k 314 2 is be VBZ cord-015922-5wwy0m2k 314 3 important important JJ cord-015922-5wwy0m2k 314 4 to to TO cord-015922-5wwy0m2k 314 5 note note VB cord-015922-5wwy0m2k 314 6 that that IN cord-015922-5wwy0m2k 314 7 a a DT cord-015922-5wwy0m2k 314 8 high high JJ cord-015922-5wwy0m2k 314 9 background background NN cord-015922-5wwy0m2k 314 10 rate rate NN cord-015922-5wwy0m2k 314 11 of of IN cord-015922-5wwy0m2k 314 12 Candida Candida NNP cord-015922-5wwy0m2k 314 13 infections infection NNS cord-015922-5wwy0m2k 314 14 was be VBD cord-015922-5wwy0m2k 314 15 noted note VBN cord-015922-5wwy0m2k 314 16 in in IN cord-015922-5wwy0m2k 314 17 both both DT cord-015922-5wwy0m2k 314 18 of of IN cord-015922-5wwy0m2k 314 19 these these DT cord-015922-5wwy0m2k 314 20 reports report NNS cord-015922-5wwy0m2k 314 21 and and CC cord-015922-5wwy0m2k 314 22 may may MD cord-015922-5wwy0m2k 314 23 not not RB cord-015922-5wwy0m2k 314 24 represent represent VB cord-015922-5wwy0m2k 314 25 the the DT cord-015922-5wwy0m2k 314 26 experience experience NN cord-015922-5wwy0m2k 314 27 of of IN cord-015922-5wwy0m2k 314 28 other other JJ cord-015922-5wwy0m2k 314 29 transplant transplant NN cord-015922-5wwy0m2k 314 30 centers center NNS cord-015922-5wwy0m2k 314 31 . . . cord-015922-5wwy0m2k 315 1 Echinocandins Echinocandins NNP cord-015922-5wwy0m2k 315 2 may may MD cord-015922-5wwy0m2k 315 3 be be VB cord-015922-5wwy0m2k 315 4 an an DT cord-015922-5wwy0m2k 315 5 alternative alternative NN cord-015922-5wwy0m2k 315 6 to to TO cord-015922-5wwy0m2k 315 7 fluconazole fluconazole VB cord-015922-5wwy0m2k 315 8 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 315 9 during during IN cord-015922-5wwy0m2k 315 10 this this DT cord-015922-5wwy0m2k 315 11 risk risk NN cord-015922-5wwy0m2k 315 12 period period NN cord-015922-5wwy0m2k 315 13 [ [ -LRB- cord-015922-5wwy0m2k 315 14 89 89 CD cord-015922-5wwy0m2k 315 15 ] ] -RRB- cord-015922-5wwy0m2k 315 16 . . . cord-015922-5wwy0m2k 316 1 The the DT cord-015922-5wwy0m2k 316 2 second second JJ cord-015922-5wwy0m2k 316 3 common common JJ cord-015922-5wwy0m2k 316 4 strategy strategy NN cord-015922-5wwy0m2k 316 5 is be VBZ cord-015922-5wwy0m2k 316 6 empiric empiric JJ cord-015922-5wwy0m2k 316 7 antifungal antifungal JJ cord-015922-5wwy0m2k 316 8 therapy therapy NN cord-015922-5wwy0m2k 316 9 in in IN cord-015922-5wwy0m2k 316 10 neutropenic neutropenic JJ cord-015922-5wwy0m2k 316 11 patients patient NNS cord-015922-5wwy0m2k 316 12 with with IN cord-015922-5wwy0m2k 316 13 persistent persistent JJ cord-015922-5wwy0m2k 316 14 fever fever NN cord-015922-5wwy0m2k 316 15 without without IN cord-015922-5wwy0m2k 316 16 a a DT cord-015922-5wwy0m2k 316 17 source source NN cord-015922-5wwy0m2k 316 18 , , , cord-015922-5wwy0m2k 316 19 despite despite IN cord-015922-5wwy0m2k 316 20 broad broad JJ cord-015922-5wwy0m2k 316 21 - - HYPH cord-015922-5wwy0m2k 316 22 spectrum spectrum NN cord-015922-5wwy0m2k 316 23 antimicrobial antimicrobial NN cord-015922-5wwy0m2k 316 24 therapy therapy NN cord-015922-5wwy0m2k 316 25 for for IN cord-015922-5wwy0m2k 316 26 > > $ cord-015922-5wwy0m2k 316 27 96 96 CD cord-015922-5wwy0m2k 316 28 hours hour NNS cord-015922-5wwy0m2k 316 29 [ [ -LRB- cord-015922-5wwy0m2k 316 30 99 99 CD cord-015922-5wwy0m2k 316 31 , , , cord-015922-5wwy0m2k 316 32 100 100 CD cord-015922-5wwy0m2k 316 33 ] ] -RRB- cord-015922-5wwy0m2k 316 34 . . . cord-015922-5wwy0m2k 317 1 In in IN cord-015922-5wwy0m2k 317 2 this this DT cord-015922-5wwy0m2k 317 3 setting set VBG cord-015922-5wwy0m2k 317 4 the the DT cord-015922-5wwy0m2k 317 5 primary primary JJ cord-015922-5wwy0m2k 317 6 concern concern NN cord-015922-5wwy0m2k 317 7 is be VBZ cord-015922-5wwy0m2k 317 8 both both CC cord-015922-5wwy0m2k 317 9 Candida Candida NNP cord-015922-5wwy0m2k 317 10 and and CC cord-015922-5wwy0m2k 317 11 invasive invasive JJ cord-015922-5wwy0m2k 317 12 mold mold NN cord-015922-5wwy0m2k 317 13 infection infection NN cord-015922-5wwy0m2k 317 14 , , , cord-015922-5wwy0m2k 317 15 especially especially RB cord-015922-5wwy0m2k 317 16 Aspergillus aspergillus NN cord-015922-5wwy0m2k 317 17 [ [ -LRB- cord-015922-5wwy0m2k 317 18 2 2 CD cord-015922-5wwy0m2k 317 19 ] ] -RRB- cord-015922-5wwy0m2k 317 20 . . . cord-015922-5wwy0m2k 318 1 The the DT cord-015922-5wwy0m2k 318 2 traditional traditional JJ cord-015922-5wwy0m2k 318 3 antifungal antifungal NN cord-015922-5wwy0m2k 318 4 therapy therapy NN cord-015922-5wwy0m2k 318 5 utilized utilize VBN cord-015922-5wwy0m2k 318 6 as as IN cord-015922-5wwy0m2k 318 7 empiric empiric JJ cord-015922-5wwy0m2k 318 8 therapy therapy NN cord-015922-5wwy0m2k 318 9 is be VBZ cord-015922-5wwy0m2k 318 10 an an DT cord-015922-5wwy0m2k 318 11 amphotericin amphotericin NN cord-015922-5wwy0m2k 318 12 product product NN cord-015922-5wwy0m2k 318 13 [ [ -LRB- cord-015922-5wwy0m2k 318 14 101 101 CD cord-015922-5wwy0m2k 318 15 , , , cord-015922-5wwy0m2k 318 16 102 102 CD cord-015922-5wwy0m2k 318 17 ] ] -RRB- cord-015922-5wwy0m2k 318 18 . . . cord-015922-5wwy0m2k 319 1 Caspofungin Caspofungin NNP cord-015922-5wwy0m2k 319 2 use use NN cord-015922-5wwy0m2k 319 3 in in IN cord-015922-5wwy0m2k 319 4 this this DT cord-015922-5wwy0m2k 319 5 setting setting NN cord-015922-5wwy0m2k 319 6 has have VBZ cord-015922-5wwy0m2k 319 7 become become VBN cord-015922-5wwy0m2k 319 8 common common JJ cord-015922-5wwy0m2k 319 9 because because IN cord-015922-5wwy0m2k 319 10 of of IN cord-015922-5wwy0m2k 319 11 the the DT cord-015922-5wwy0m2k 319 12 favorable favorable JJ cord-015922-5wwy0m2k 319 13 side side NN cord-015922-5wwy0m2k 319 14 effect effect NN cord-015922-5wwy0m2k 319 15 profile profile NN cord-015922-5wwy0m2k 319 16 of of IN cord-015922-5wwy0m2k 319 17 this this DT cord-015922-5wwy0m2k 319 18 class class NN cord-015922-5wwy0m2k 319 19 of of IN cord-015922-5wwy0m2k 319 20 agents agent NNS cord-015922-5wwy0m2k 319 21 , , , cord-015922-5wwy0m2k 319 22 but but CC cord-015922-5wwy0m2k 319 23 at at IN cord-015922-5wwy0m2k 319 24 the the DT cord-015922-5wwy0m2k 319 25 expense expense NN cord-015922-5wwy0m2k 319 26 of of IN cord-015922-5wwy0m2k 319 27 a a DT cord-015922-5wwy0m2k 319 28 more more RBR cord-015922-5wwy0m2k 319 29 limited limited JJ cord-015922-5wwy0m2k 319 30 fungal fungal NN cord-015922-5wwy0m2k 319 31 spectrum spectrum NN cord-015922-5wwy0m2k 319 32 [ [ -LRB- cord-015922-5wwy0m2k 319 33 90 90 CD cord-015922-5wwy0m2k 319 34 ] ] -RRB- cord-015922-5wwy0m2k 319 35 . . . cord-015922-5wwy0m2k 320 1 Other other JJ cord-015922-5wwy0m2k 320 2 echinocandins echinocandin NNS cord-015922-5wwy0m2k 320 3 ( ( -LRB- cord-015922-5wwy0m2k 320 4 micafungin micafungin NNP cord-015922-5wwy0m2k 320 5 , , , cord-015922-5wwy0m2k 320 6 anidulafungin anidulafungin NNP cord-015922-5wwy0m2k 320 7 ) ) -RRB- cord-015922-5wwy0m2k 320 8 are be VBP cord-015922-5wwy0m2k 320 9 likely likely JJ cord-015922-5wwy0m2k 320 10 to to TO cord-015922-5wwy0m2k 320 11 be be VB cord-015922-5wwy0m2k 320 12 similarly similarly RB cord-015922-5wwy0m2k 320 13 effective effective JJ cord-015922-5wwy0m2k 320 14 , , , cord-015922-5wwy0m2k 320 15 but but CC cord-015922-5wwy0m2k 320 16 no no DT cord-015922-5wwy0m2k 320 17 randomized randomized JJ cord-015922-5wwy0m2k 320 18 comparisons comparison NNS cord-015922-5wwy0m2k 320 19 with with IN cord-015922-5wwy0m2k 320 20 these these DT cord-015922-5wwy0m2k 320 21 latest late JJS cord-015922-5wwy0m2k 320 22 drugs drug NNS cord-015922-5wwy0m2k 320 23 have have VBP cord-015922-5wwy0m2k 320 24 been be VBN cord-015922-5wwy0m2k 320 25 performed perform VBN cord-015922-5wwy0m2k 320 26 . . . cord-015922-5wwy0m2k 321 1 The the DT cord-015922-5wwy0m2k 321 2 role role NN cord-015922-5wwy0m2k 321 3 of of IN cord-015922-5wwy0m2k 321 4 voriconazole voriconazole NN cord-015922-5wwy0m2k 321 5 in in IN cord-015922-5wwy0m2k 321 6 this this DT cord-015922-5wwy0m2k 321 7 setting setting NN cord-015922-5wwy0m2k 321 8 is be VBZ cord-015922-5wwy0m2k 321 9 controversial controversial JJ cord-015922-5wwy0m2k 321 10 [ [ -LRB- cord-015922-5wwy0m2k 321 11 102 102 CD cord-015922-5wwy0m2k 321 12 ] ] -RRB- cord-015922-5wwy0m2k 321 13 . . . cord-015922-5wwy0m2k 322 1 When when WRB cord-015922-5wwy0m2k 322 2 treating treat VBG cord-015922-5wwy0m2k 322 3 invasive invasive JJ cord-015922-5wwy0m2k 322 4 aspergillosis aspergillosis NN cord-015922-5wwy0m2k 322 5 several several JJ cord-015922-5wwy0m2k 322 6 approaches approach NNS cord-015922-5wwy0m2k 322 7 should should MD cord-015922-5wwy0m2k 322 8 be be VB cord-015922-5wwy0m2k 322 9 considered consider VBN cord-015922-5wwy0m2k 322 10 simultaneously simultaneously RB cord-015922-5wwy0m2k 322 11 : : : cord-015922-5wwy0m2k 322 12 1 1 LS cord-015922-5wwy0m2k 322 13 ) ) -RRB- cord-015922-5wwy0m2k 322 14 antifungal antifungal NN cord-015922-5wwy0m2k 322 15 therapy therapy NN cord-015922-5wwy0m2k 322 16 , , , cord-015922-5wwy0m2k 322 17 2 2 LS cord-015922-5wwy0m2k 322 18 ) ) -RRB- cord-015922-5wwy0m2k 322 19 reverse reverse VBP cord-015922-5wwy0m2k 322 20 or or CC cord-015922-5wwy0m2k 322 21 minimize minimize VB cord-015922-5wwy0m2k 322 22 the the DT cord-015922-5wwy0m2k 322 23 host host NN cord-015922-5wwy0m2k 322 24 immune immune JJ cord-015922-5wwy0m2k 322 25 defects defect NNS cord-015922-5wwy0m2k 322 26 ( ( -LRB- cord-015922-5wwy0m2k 322 27 decrease decrease NN cord-015922-5wwy0m2k 322 28 corticosteroids corticosteroid NNS cord-015922-5wwy0m2k 322 29 , , , cord-015922-5wwy0m2k 322 30 increase increase VBP cord-015922-5wwy0m2k 322 31 neutrophils neutrophil NNS cord-015922-5wwy0m2k 322 32 ) ) -RRB- cord-015922-5wwy0m2k 322 33 , , , cord-015922-5wwy0m2k 322 34 3 3 LS cord-015922-5wwy0m2k 322 35 ) ) -RRB- cord-015922-5wwy0m2k 322 36 control control VBP cord-015922-5wwy0m2k 322 37 permissive permissive JJ cord-015922-5wwy0m2k 322 38 viral viral JJ cord-015922-5wwy0m2k 322 39 infections infection NNS cord-015922-5wwy0m2k 323 1 ( ( -LRB- cord-015922-5wwy0m2k 323 2 e.g. e.g. RB cord-015922-5wwy0m2k 323 3 , , , cord-015922-5wwy0m2k 323 4 CMV CMV NNP cord-015922-5wwy0m2k 323 5 ) ) -RRB- cord-015922-5wwy0m2k 323 6 and and CC cord-015922-5wwy0m2k 323 7 4 4 LS cord-015922-5wwy0m2k 323 8 ) ) -RRB- cord-015922-5wwy0m2k 323 9 consider consider VB cord-015922-5wwy0m2k 323 10 surgical surgical JJ cord-015922-5wwy0m2k 323 11 excision excision NN cord-015922-5wwy0m2k 323 12 , , , cord-015922-5wwy0m2k 323 13 if if IN cord-015922-5wwy0m2k 323 14 possible possible JJ cord-015922-5wwy0m2k 323 15 . . . cord-015922-5wwy0m2k 324 1 Voriconazole Voriconazole NNP cord-015922-5wwy0m2k 324 2 has have VBZ cord-015922-5wwy0m2k 324 3 become become VBN cord-015922-5wwy0m2k 324 4 a a DT cord-015922-5wwy0m2k 324 5 cornerstone cornerstone NN cord-015922-5wwy0m2k 324 6 of of IN cord-015922-5wwy0m2k 324 7 therapy therapy NN cord-015922-5wwy0m2k 324 8 for for IN cord-015922-5wwy0m2k 324 9 invasive invasive JJ cord-015922-5wwy0m2k 324 10 Aspergillus aspergillus NN cord-015922-5wwy0m2k 324 11 infections infection NNS cord-015922-5wwy0m2k 324 12 , , , cord-015922-5wwy0m2k 324 13 though though IN cord-015922-5wwy0m2k 324 14 the the DT cord-015922-5wwy0m2k 324 15 management management NN cord-015922-5wwy0m2k 324 16 of of IN cord-015922-5wwy0m2k 324 17 potential potential JJ cord-015922-5wwy0m2k 324 18 side side NN cord-015922-5wwy0m2k 324 19 effects effect NNS cord-015922-5wwy0m2k 324 20 is be VBZ cord-015922-5wwy0m2k 324 21 substantial substantial JJ cord-015922-5wwy0m2k 324 22 [ [ -LRB- cord-015922-5wwy0m2k 324 23 103 103 CD cord-015922-5wwy0m2k 324 24 ] ] -RRB- cord-015922-5wwy0m2k 324 25 [ [ -LRB- cord-015922-5wwy0m2k 324 26 104 104 CD cord-015922-5wwy0m2k 324 27 ] ] -RRB- cord-015922-5wwy0m2k 324 28 [ [ -LRB- cord-015922-5wwy0m2k 324 29 105 105 CD cord-015922-5wwy0m2k 324 30 ] ] -RRB- cord-015922-5wwy0m2k 324 31 . . . cord-015922-5wwy0m2k 325 1 Whether whether IN cord-015922-5wwy0m2k 325 2 the the DT cord-015922-5wwy0m2k 325 3 combination combination NN cord-015922-5wwy0m2k 325 4 of of IN cord-015922-5wwy0m2k 325 5 therapeutic therapeutic JJ cord-015922-5wwy0m2k 325 6 agents agent NNS cord-015922-5wwy0m2k 325 7 ( ( -LRB- cord-015922-5wwy0m2k 325 8 polyenes polyenes NNPS cord-015922-5wwy0m2k 325 9 , , , cord-015922-5wwy0m2k 325 10 azoles azoles NNP cord-015922-5wwy0m2k 325 11 and and CC cord-015922-5wwy0m2k 325 12 echinocandins echinocandins NNP cord-015922-5wwy0m2k 325 13 ) ) -RRB- cord-015922-5wwy0m2k 325 14 increases increase VBZ cord-015922-5wwy0m2k 325 15 the the DT cord-015922-5wwy0m2k 325 16 therapeutic therapeutic JJ cord-015922-5wwy0m2k 325 17 benefit benefit NN cord-015922-5wwy0m2k 325 18 has have VBZ cord-015922-5wwy0m2k 325 19 yet yet RB cord-015922-5wwy0m2k 325 20 to to TO cord-015922-5wwy0m2k 325 21 be be VB cord-015922-5wwy0m2k 325 22 determined determine VBN cord-015922-5wwy0m2k 325 23 [ [ -LRB- cord-015922-5wwy0m2k 325 24 106 106 CD cord-015922-5wwy0m2k 325 25 ] ] -RRB- cord-015922-5wwy0m2k 325 26 . . . cord-015922-5wwy0m2k 326 1 Increasing increase VBG cord-015922-5wwy0m2k 326 2 experience experience NN cord-015922-5wwy0m2k 326 3 suggests suggest VBZ cord-015922-5wwy0m2k 326 4 that that IN cord-015922-5wwy0m2k 326 5 voriconazole voriconazole NN cord-015922-5wwy0m2k 326 6 alone alone RB cord-015922-5wwy0m2k 326 7 is be VBZ cord-015922-5wwy0m2k 326 8 sufficient sufficient JJ cord-015922-5wwy0m2k 326 9 in in IN cord-015922-5wwy0m2k 326 10 most most JJS cord-015922-5wwy0m2k 326 11 cases case NNS cord-015922-5wwy0m2k 326 12 for for IN cord-015922-5wwy0m2k 326 13 a a DT cord-015922-5wwy0m2k 326 14 successful successful JJ cord-015922-5wwy0m2k 326 15 outcome outcome NN cord-015922-5wwy0m2k 326 16 in in IN cord-015922-5wwy0m2k 326 17 invasive invasive JJ cord-015922-5wwy0m2k 326 18 aspergillosis aspergillosis NN cord-015922-5wwy0m2k 326 19 and and CC cord-015922-5wwy0m2k 326 20 has have VBZ cord-015922-5wwy0m2k 326 21 decreased decrease VBN cord-015922-5wwy0m2k 326 22 the the DT cord-015922-5wwy0m2k 326 23 morbidity morbidity NN cord-015922-5wwy0m2k 326 24 and and CC cord-015922-5wwy0m2k 326 25 mortality mortality NN cord-015922-5wwy0m2k 326 26 of of IN cord-015922-5wwy0m2k 326 27 this this DT cord-015922-5wwy0m2k 326 28 infection infection NN cord-015922-5wwy0m2k 326 29 [ [ -LRB- cord-015922-5wwy0m2k 326 30 11 11 CD cord-015922-5wwy0m2k 326 31 , , , cord-015922-5wwy0m2k 326 32 106 106 CD cord-015922-5wwy0m2k 326 33 ] ] -RRB- cord-015922-5wwy0m2k 326 34 . . . cord-015922-5wwy0m2k 327 1 Another another DT cord-015922-5wwy0m2k 327 2 significant significant JJ cord-015922-5wwy0m2k 327 3 risk risk NN cord-015922-5wwy0m2k 327 4 period period NN cord-015922-5wwy0m2k 327 5 for for IN cord-015922-5wwy0m2k 327 6 invasive invasive JJ cord-015922-5wwy0m2k 327 7 fungal fungal JJ cord-015922-5wwy0m2k 327 8 infections infection NNS cord-015922-5wwy0m2k 327 9 ( ( -LRB- cord-015922-5wwy0m2k 327 10 IFI IFI NNP cord-015922-5wwy0m2k 327 11 ) ) -RRB- cord-015922-5wwy0m2k 327 12 is be VBZ cord-015922-5wwy0m2k 327 13 in in IN cord-015922-5wwy0m2k 327 14 the the DT cord-015922-5wwy0m2k 327 15 setting setting NN cord-015922-5wwy0m2k 327 16 of of IN cord-015922-5wwy0m2k 327 17 significant significant JJ cord-015922-5wwy0m2k 327 18 GVHD GVHD NNP cord-015922-5wwy0m2k 327 19 , , , cord-015922-5wwy0m2k 327 20 such such JJ cord-015922-5wwy0m2k 327 21 as as IN cord-015922-5wwy0m2k 327 22 grade grade NN cord-015922-5wwy0m2k 327 23 III III NNP cord-015922-5wwy0m2k 327 24 or or CC cord-015922-5wwy0m2k 327 25 IV IV NNP cord-015922-5wwy0m2k 327 26 , , , cord-015922-5wwy0m2k 327 27 and and CC cord-015922-5wwy0m2k 327 28 its -PRON- PRP$ cord-015922-5wwy0m2k 327 29 therapy therapy NN cord-015922-5wwy0m2k 327 30 [ [ -LRB- cord-015922-5wwy0m2k 327 31 9 9 CD cord-015922-5wwy0m2k 327 32 ] ] -RRB- cord-015922-5wwy0m2k 327 33 . . . cord-015922-5wwy0m2k 328 1 In in IN cord-015922-5wwy0m2k 328 2 this this DT cord-015922-5wwy0m2k 328 3 setting setting NN cord-015922-5wwy0m2k 328 4 , , , cord-015922-5wwy0m2k 328 5 posaconazole posaconazole NNP cord-015922-5wwy0m2k 328 6 ( ( -LRB- cord-015922-5wwy0m2k 328 7 versus versus IN cord-015922-5wwy0m2k 328 8 fluconazole fluconazole NNP cord-015922-5wwy0m2k 328 9 ) ) -RRB- cord-015922-5wwy0m2k 328 10 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 328 11 has have VBZ cord-015922-5wwy0m2k 328 12 recently recently RB cord-015922-5wwy0m2k 328 13 demonstrated demonstrate VBN cord-015922-5wwy0m2k 328 14 some some DT cord-015922-5wwy0m2k 328 15 benefit benefit NN cord-015922-5wwy0m2k 328 16 in in IN cord-015922-5wwy0m2k 328 17 preventing prevent VBG cord-015922-5wwy0m2k 328 18 IFI IFI NNP cord-015922-5wwy0m2k 328 19 compared compare VBN cord-015922-5wwy0m2k 328 20 to to IN cord-015922-5wwy0m2k 328 21 fluconazole fluconazole NN cord-015922-5wwy0m2k 328 22 ( ( -LRB- cord-015922-5wwy0m2k 328 23 5.3 5.3 CD cord-015922-5wwy0m2k 328 24 % % NN cord-015922-5wwy0m2k 328 25 versus versus IN cord-015922-5wwy0m2k 328 26 9.0 9.0 CD cord-015922-5wwy0m2k 328 27 % % NN cord-015922-5wwy0m2k 328 28 , , , cord-015922-5wwy0m2k 328 29 p p NN cord-015922-5wwy0m2k 328 30 = = SYM cord-015922-5wwy0m2k 328 31 0.07 0.07 CD cord-015922-5wwy0m2k 328 32 ) ) -RRB- cord-015922-5wwy0m2k 328 33 and and CC cord-015922-5wwy0m2k 328 34 in in IN cord-015922-5wwy0m2k 328 35 preventing prevent VBG cord-015922-5wwy0m2k 328 36 probable probable JJ cord-015922-5wwy0m2k 328 37 or or CC cord-015922-5wwy0m2k 328 38 proven prove VBN cord-015922-5wwy0m2k 328 39 invasive invasive JJ cord-015922-5wwy0m2k 328 40 aspergillosis aspergillosis NN cord-015922-5wwy0m2k 328 41 ( ( -LRB- cord-015922-5wwy0m2k 328 42 2.3 2.3 CD cord-015922-5wwy0m2k 328 43 % % NN cord-015922-5wwy0m2k 328 44 versus versus IN cord-015922-5wwy0m2k 328 45 7.0 7.0 CD cord-015922-5wwy0m2k 328 46 % % NN cord-015922-5wwy0m2k 328 47 , , , cord-015922-5wwy0m2k 328 48 p p NN cord-015922-5wwy0m2k 328 49 = = SYM cord-015922-5wwy0m2k 328 50 0.006 0.006 CD cord-015922-5wwy0m2k 328 51 -interestingly -interestingly RB cord-015922-5wwy0m2k 328 52 , , , cord-015922-5wwy0m2k 328 53 these these DT cord-015922-5wwy0m2k 328 54 results result NNS cord-015922-5wwy0m2k 328 55 were be VBD cord-015922-5wwy0m2k 328 56 largely largely RB cord-015922-5wwy0m2k 328 57 driven drive VBN cord-015922-5wwy0m2k 328 58 by by IN cord-015922-5wwy0m2k 328 59 results result NNS cord-015922-5wwy0m2k 328 60 from from IN cord-015922-5wwy0m2k 328 61 galactomannan galactomannan NNP cord-015922-5wwy0m2k 328 62 assay assay NNP cord-015922-5wwy0m2k 328 63 testing testing NN cord-015922-5wwy0m2k 328 64 ) ) -RRB- cord-015922-5wwy0m2k 329 1 [ [ -LRB- cord-015922-5wwy0m2k 329 2 107 107 CD cord-015922-5wwy0m2k 329 3 ] ] -RRB- cord-015922-5wwy0m2k 330 1 [ [ -LRB- cord-015922-5wwy0m2k 330 2 108 108 CD cord-015922-5wwy0m2k 330 3 ] ] -RRB- cord-015922-5wwy0m2k 330 4 [ [ -LRB- cord-015922-5wwy0m2k 330 5 109 109 CD cord-015922-5wwy0m2k 330 6 ] ] -RRB- cord-015922-5wwy0m2k 330 7 . . . cord-015922-5wwy0m2k 331 1 Posaconazole Posaconazole NNP cord-015922-5wwy0m2k 331 2 has have VBZ cord-015922-5wwy0m2k 331 3 activity activity NN cord-015922-5wwy0m2k 331 4 against against IN cord-015922-5wwy0m2k 331 5 the the DT cord-015922-5wwy0m2k 331 6 Zygomycetes Zygomycetes NNPS cord-015922-5wwy0m2k 331 7 as as RB cord-015922-5wwy0m2k 331 8 well well RB cord-015922-5wwy0m2k 331 9 as as IN cord-015922-5wwy0m2k 331 10 Aspergillus aspergillus NN cord-015922-5wwy0m2k 331 11 sp sp NN cord-015922-5wwy0m2k 331 12 [ [ -LRB- cord-015922-5wwy0m2k 331 13 110 110 CD cord-015922-5wwy0m2k 331 14 ] ] -RRB- cord-015922-5wwy0m2k 331 15 [ [ -LRB- cord-015922-5wwy0m2k 331 16 111 111 CD cord-015922-5wwy0m2k 331 17 ] ] -RRB- cord-015922-5wwy0m2k 331 18 [ [ -LRB- cord-015922-5wwy0m2k 331 19 112 112 CD cord-015922-5wwy0m2k 331 20 ] ] -RRB- cord-015922-5wwy0m2k 331 21 . . . cord-015922-5wwy0m2k 332 1 When when WRB cord-015922-5wwy0m2k 332 2 an an DT cord-015922-5wwy0m2k 332 3 azole azole NN cord-015922-5wwy0m2k 332 4 is be VBZ cord-015922-5wwy0m2k 332 5 used use VBN cord-015922-5wwy0m2k 332 6 in in IN cord-015922-5wwy0m2k 332 7 this this DT cord-015922-5wwy0m2k 332 8 patient patient JJ cord-015922-5wwy0m2k 332 9 population population NN cord-015922-5wwy0m2k 332 10 , , , cord-015922-5wwy0m2k 332 11 careful careful JJ cord-015922-5wwy0m2k 332 12 assessment assessment NN cord-015922-5wwy0m2k 332 13 of of IN cord-015922-5wwy0m2k 332 14 drug drug NN cord-015922-5wwy0m2k 332 15 interactions interaction NNS cord-015922-5wwy0m2k 332 16 , , , cord-015922-5wwy0m2k 332 17 both both CC cord-015922-5wwy0m2k 332 18 with with IN cord-015922-5wwy0m2k 332 19 the the DT cord-015922-5wwy0m2k 332 20 initiation initiation NN cord-015922-5wwy0m2k 332 21 and and CC cord-015922-5wwy0m2k 332 22 cessation cessation NN cord-015922-5wwy0m2k 332 23 of of IN cord-015922-5wwy0m2k 332 24 therapy therapy NN cord-015922-5wwy0m2k 332 25 , , , cord-015922-5wwy0m2k 332 26 is be VBZ cord-015922-5wwy0m2k 332 27 critical critical JJ cord-015922-5wwy0m2k 332 28 . . . cord-015922-5wwy0m2k 333 1 Therapy therapy NN cord-015922-5wwy0m2k 333 2 for for IN cord-015922-5wwy0m2k 333 3 the the DT cord-015922-5wwy0m2k 333 4 emerging emerge VBG cord-015922-5wwy0m2k 333 5 fungi fungus NNS cord-015922-5wwy0m2k 333 6 Fusarium Fusarium NNP cord-015922-5wwy0m2k 333 7 and and CC cord-015922-5wwy0m2k 333 8 Scedosporium Scedosporium NNP cord-015922-5wwy0m2k 333 9 should should MD cord-015922-5wwy0m2k 333 10 be be VB cord-015922-5wwy0m2k 333 11 guided guide VBN cord-015922-5wwy0m2k 333 12 by by IN cord-015922-5wwy0m2k 333 13 in in FW cord-015922-5wwy0m2k 333 14 vitro vitro FW cord-015922-5wwy0m2k 333 15 sensitivity sensitivity NN cord-015922-5wwy0m2k 333 16 testing testing NN cord-015922-5wwy0m2k 333 17 done do VBN cord-015922-5wwy0m2k 333 18 locally locally RB cord-015922-5wwy0m2k 333 19 or or CC cord-015922-5wwy0m2k 333 20 at at IN cord-015922-5wwy0m2k 333 21 regional regional JJ cord-015922-5wwy0m2k 333 22 reference reference NN cord-015922-5wwy0m2k 333 23 laboratories laboratory NNS cord-015922-5wwy0m2k 333 24 , , , cord-015922-5wwy0m2k 333 25 but but CC cord-015922-5wwy0m2k 333 26 voriconazole voriconazole NN cord-015922-5wwy0m2k 333 27 use use NN cord-015922-5wwy0m2k 333 28 should should MD cord-015922-5wwy0m2k 333 29 be be VB cord-015922-5wwy0m2k 333 30 considered consider VBN cord-015922-5wwy0m2k 333 31 . . . cord-015922-5wwy0m2k 334 1 When when WRB cord-015922-5wwy0m2k 334 2 therapy therapy NN cord-015922-5wwy0m2k 334 3 for for IN cord-015922-5wwy0m2k 334 4 the the DT cord-015922-5wwy0m2k 334 5 endemic endemic JJ cord-015922-5wwy0m2k 334 6 mycoses mycose NNS cord-015922-5wwy0m2k 334 7 is be VBZ cord-015922-5wwy0m2k 334 8 indicated indicate VBN cord-015922-5wwy0m2k 334 9 , , , cord-015922-5wwy0m2k 334 10 initial initial JJ cord-015922-5wwy0m2k 334 11 treatment treatment NN cord-015922-5wwy0m2k 334 12 ( ( -LRB- cord-015922-5wwy0m2k 334 13 induction induction NN cord-015922-5wwy0m2k 334 14 therapy therapy NN cord-015922-5wwy0m2k 334 15 ) ) -RRB- cord-015922-5wwy0m2k 334 16 with with IN cord-015922-5wwy0m2k 334 17 an an DT cord-015922-5wwy0m2k 334 18 amphotericin amphotericin NN cord-015922-5wwy0m2k 334 19 preparation preparation NN cord-015922-5wwy0m2k 334 20 should should MD cord-015922-5wwy0m2k 334 21 be be VB cord-015922-5wwy0m2k 334 22 considered consider VBN cord-015922-5wwy0m2k 334 23 , , , cord-015922-5wwy0m2k 334 24 followed follow VBN cord-015922-5wwy0m2k 334 25 by by IN cord-015922-5wwy0m2k 334 26 a a DT cord-015922-5wwy0m2k 334 27 prolonged prolonged JJ cord-015922-5wwy0m2k 334 28 course course NN cord-015922-5wwy0m2k 334 29 of of IN cord-015922-5wwy0m2k 334 30 consolidative consolidative JJ cord-015922-5wwy0m2k 334 31 therapy therapy NN cord-015922-5wwy0m2k 334 32 with with IN cord-015922-5wwy0m2k 334 33 an an DT cord-015922-5wwy0m2k 334 34 oral oral JJ cord-015922-5wwy0m2k 334 35 azole azole NN cord-015922-5wwy0m2k 334 36 . . . cord-015922-5wwy0m2k 335 1 Cryptococcal cryptococcal JJ cord-015922-5wwy0m2k 335 2 disease disease NN cord-015922-5wwy0m2k 335 3 should should MD cord-015922-5wwy0m2k 335 4 be be VB cord-015922-5wwy0m2k 335 5 treated treat VBN cord-015922-5wwy0m2k 335 6 initially initially RB cord-015922-5wwy0m2k 335 7 with with IN cord-015922-5wwy0m2k 335 8 an an DT cord-015922-5wwy0m2k 335 9 amphotericin amphotericin NN cord-015922-5wwy0m2k 335 10 preparation preparation NN cord-015922-5wwy0m2k 335 11 , , , cord-015922-5wwy0m2k 335 12 CNS CNS NNP cord-015922-5wwy0m2k 335 13 involvement involvement NN cord-015922-5wwy0m2k 335 14 should should MD cord-015922-5wwy0m2k 335 15 be be VB cord-015922-5wwy0m2k 335 16 excluded exclude VBN cord-015922-5wwy0m2k 335 17 by by IN cord-015922-5wwy0m2k 335 18 cerebrospinal cerebrospinal JJ cord-015922-5wwy0m2k 335 19 fluid fluid JJ cord-015922-5wwy0m2k 335 20 sampling sampling NN cord-015922-5wwy0m2k 335 21 , , , cord-015922-5wwy0m2k 335 22 and and CC cord-015922-5wwy0m2k 335 23 the the DT cord-015922-5wwy0m2k 335 24 use use NN cord-015922-5wwy0m2k 335 25 of of IN cord-015922-5wwy0m2k 335 26 flucytosine flucytosine NN cord-015922-5wwy0m2k 335 27 should should MD cord-015922-5wwy0m2k 335 28 be be VB cord-015922-5wwy0m2k 335 29 considered consider VBN cord-015922-5wwy0m2k 335 30 if if IN cord-015922-5wwy0m2k 335 31 present present JJ cord-015922-5wwy0m2k 335 32 . . . cord-015922-5wwy0m2k 336 1 Pneumocystis Pneumocystis NNP cord-015922-5wwy0m2k 336 2 jiroveci jiroveci NNP cord-015922-5wwy0m2k 336 3 , , , cord-015922-5wwy0m2k 336 4 formerly formerly RB cord-015922-5wwy0m2k 336 5 carinii carinii FW cord-015922-5wwy0m2k 336 6 , , , cord-015922-5wwy0m2k 336 7 is be VBZ cord-015922-5wwy0m2k 336 8 a a DT cord-015922-5wwy0m2k 336 9 ubiquitous ubiquitous JJ cord-015922-5wwy0m2k 336 10 environmental environmental JJ cord-015922-5wwy0m2k 336 11 organism organism NN cord-015922-5wwy0m2k 336 12 which which WDT cord-015922-5wwy0m2k 336 13 is be VBZ cord-015922-5wwy0m2k 336 14 an an DT cord-015922-5wwy0m2k 336 15 important important JJ cord-015922-5wwy0m2k 336 16 cause cause NN cord-015922-5wwy0m2k 336 17 of of IN cord-015922-5wwy0m2k 336 18 pneumonia pneumonia NN cord-015922-5wwy0m2k 336 19 in in IN cord-015922-5wwy0m2k 336 20 patients patient NNS cord-015922-5wwy0m2k 336 21 who who WP cord-015922-5wwy0m2k 336 22 are be VBP cord-015922-5wwy0m2k 336 23 immunosuppressed immunosuppressed JJ cord-015922-5wwy0m2k 336 24 , , , cord-015922-5wwy0m2k 336 25 such such JJ cord-015922-5wwy0m2k 336 26 as as IN cord-015922-5wwy0m2k 336 27 those those DT cord-015922-5wwy0m2k 336 28 who who WP cord-015922-5wwy0m2k 336 29 have have VBP cord-015922-5wwy0m2k 336 30 undergone undergo VBN cord-015922-5wwy0m2k 336 31 an an DT cord-015922-5wwy0m2k 336 32 HSCT HSCT NNP cord-015922-5wwy0m2k 336 33 , , , cord-015922-5wwy0m2k 336 34 on on IN cord-015922-5wwy0m2k 336 35 chronic chronic JJ cord-015922-5wwy0m2k 336 36 prednisone prednisone NN cord-015922-5wwy0m2k 336 37 ( ( -LRB- cord-015922-5wwy0m2k 336 38 typically typically RB cord-015922-5wwy0m2k 336 39 > > XX cord-015922-5wwy0m2k 336 40 20 20 CD cord-015922-5wwy0m2k 336 41 mg mg NN cord-015922-5wwy0m2k 336 42 per per IN cord-015922-5wwy0m2k 336 43 day day NN cord-015922-5wwy0m2k 336 44 ) ) -RRB- cord-015922-5wwy0m2k 336 45 or or CC cord-015922-5wwy0m2k 336 46 with with IN cord-015922-5wwy0m2k 336 47 advanced advanced JJ cord-015922-5wwy0m2k 336 48 HIV HIV NNP cord-015922-5wwy0m2k 336 49 infection infection NN cord-015922-5wwy0m2k 336 50 . . . cord-015922-5wwy0m2k 337 1 PCP PCP NNP cord-015922-5wwy0m2k 337 2 infection infection NN cord-015922-5wwy0m2k 337 3 typically typically RB cord-015922-5wwy0m2k 337 4 presents present VBZ cord-015922-5wwy0m2k 337 5 as as IN cord-015922-5wwy0m2k 337 6 an an DT cord-015922-5wwy0m2k 337 7 interstitial interstitial JJ cord-015922-5wwy0m2k 337 8 pneumonitis pneumonitis NN cord-015922-5wwy0m2k 337 9 with with IN cord-015922-5wwy0m2k 337 10 marked marked JJ cord-015922-5wwy0m2k 337 11 hypoxemia hypoxemia NN cord-015922-5wwy0m2k 337 12 . . . cord-015922-5wwy0m2k 338 1 Severe severe JJ cord-015922-5wwy0m2k 338 2 infection infection NN cord-015922-5wwy0m2k 338 3 can can MD cord-015922-5wwy0m2k 338 4 be be VB cord-015922-5wwy0m2k 338 5 life life NN cord-015922-5wwy0m2k 338 6 threatening threaten VBG cord-015922-5wwy0m2k 338 7 . . . cord-015922-5wwy0m2k 339 1 Fortunately fortunately RB cord-015922-5wwy0m2k 339 2 , , , cord-015922-5wwy0m2k 339 3 universal universal JJ cord-015922-5wwy0m2k 339 4 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 339 5 of of IN cord-015922-5wwy0m2k 339 6 high high JJ cord-015922-5wwy0m2k 339 7 risk risk NN cord-015922-5wwy0m2k 339 8 patients patient NNS cord-015922-5wwy0m2k 339 9 during during IN cord-015922-5wwy0m2k 339 10 the the DT cord-015922-5wwy0m2k 339 11 high high JJ cord-015922-5wwy0m2k 339 12 risk risk NN cord-015922-5wwy0m2k 339 13 periods period NNS cord-015922-5wwy0m2k 339 14 with with IN cord-015922-5wwy0m2k 339 15 trimethoprim trimethoprim NNP cord-015922-5wwy0m2k 339 16 - - HYPH cord-015922-5wwy0m2k 339 17 sulfamethoxazole sulfamethoxazole NNP cord-015922-5wwy0m2k 339 18 has have VBZ cord-015922-5wwy0m2k 339 19 markedly markedly RB cord-015922-5wwy0m2k 339 20 decreased decrease VBN cord-015922-5wwy0m2k 339 21 this this DT cord-015922-5wwy0m2k 339 22 complication complication NN cord-015922-5wwy0m2k 339 23 . . . cord-015922-5wwy0m2k 340 1 However however RB cord-015922-5wwy0m2k 340 2 , , , cord-015922-5wwy0m2k 340 3 intolerance intolerance NN cord-015922-5wwy0m2k 340 4 to to IN cord-015922-5wwy0m2k 340 5 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 340 6 , , , cord-015922-5wwy0m2k 340 7 use use NN cord-015922-5wwy0m2k 340 8 of of IN cord-015922-5wwy0m2k 340 9 second second JJ cord-015922-5wwy0m2k 340 10 line line NN cord-015922-5wwy0m2k 340 11 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 340 12 agents agent NNS cord-015922-5wwy0m2k 340 13 ( ( -LRB- cord-015922-5wwy0m2k 340 14 e.g. e.g. RB cord-015922-5wwy0m2k 340 15 , , , cord-015922-5wwy0m2k 340 16 dapsone dapsone NN cord-015922-5wwy0m2k 340 17 , , , cord-015922-5wwy0m2k 340 18 pentamidine pentamidine NNP cord-015922-5wwy0m2k 340 19 , , , cord-015922-5wwy0m2k 340 20 or or CC cord-015922-5wwy0m2k 340 21 atovaquone atovaquone NNP cord-015922-5wwy0m2k 340 22 ) ) -RRB- cord-015922-5wwy0m2k 340 23 , , , cord-015922-5wwy0m2k 340 24 poor poor JJ cord-015922-5wwy0m2k 340 25 medication medication NN cord-015922-5wwy0m2k 340 26 compliance compliance NN cord-015922-5wwy0m2k 340 27 or or CC cord-015922-5wwy0m2k 340 28 failure failure NN cord-015922-5wwy0m2k 340 29 to to TO cord-015922-5wwy0m2k 340 30 re re VB cord-015922-5wwy0m2k 340 31 - - JJ cord-015922-5wwy0m2k 340 32 institute institute JJ cord-015922-5wwy0m2k 340 33 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 340 34 in in IN cord-015922-5wwy0m2k 340 35 the the DT cord-015922-5wwy0m2k 340 36 setting setting NN cord-015922-5wwy0m2k 340 37 of of IN cord-015922-5wwy0m2k 340 38 augmented augment VBN cord-015922-5wwy0m2k 340 39 immunosuppression immunosuppression NN cord-015922-5wwy0m2k 340 40 ( ( -LRB- cord-015922-5wwy0m2k 340 41 e.g. e.g. RB cord-015922-5wwy0m2k 340 42 , , , cord-015922-5wwy0m2k 340 43 treatment treatment NN cord-015922-5wwy0m2k 340 44 of of IN cord-015922-5wwy0m2k 340 45 GVHD GVHD NNP cord-015922-5wwy0m2k 340 46 ) ) -RRB- cord-015922-5wwy0m2k 340 47 are be VBP cord-015922-5wwy0m2k 340 48 common common JJ cord-015922-5wwy0m2k 340 49 reasons reason NNS cord-015922-5wwy0m2k 340 50 why why WRB cord-015922-5wwy0m2k 340 51 cases case NNS cord-015922-5wwy0m2k 340 52 still still RB cord-015922-5wwy0m2k 340 53 occur occur VBP cord-015922-5wwy0m2k 340 54 . . . cord-015922-5wwy0m2k 341 1 Several several JJ cord-015922-5wwy0m2k 341 2 important important JJ cord-015922-5wwy0m2k 341 3 issues issue NNS cord-015922-5wwy0m2k 341 4 must must MD cord-015922-5wwy0m2k 341 5 be be VB cord-015922-5wwy0m2k 341 6 addressed address VBN cord-015922-5wwy0m2k 341 7 after after IN cord-015922-5wwy0m2k 341 8 successful successful JJ cord-015922-5wwy0m2k 341 9 HSCT HSCT NNP cord-015922-5wwy0m2k 341 10 to to TO cord-015922-5wwy0m2k 341 11 minimize minimize VB cord-015922-5wwy0m2k 341 12 infectious infectious JJ cord-015922-5wwy0m2k 341 13 complications complication NNS cord-015922-5wwy0m2k 341 14 . . . cord-015922-5wwy0m2k 342 1 First first RB cord-015922-5wwy0m2k 342 2 , , , cord-015922-5wwy0m2k 342 3 it -PRON- PRP cord-015922-5wwy0m2k 342 4 is be VBZ cord-015922-5wwy0m2k 342 5 important important JJ cord-015922-5wwy0m2k 342 6 to to TO cord-015922-5wwy0m2k 342 7 avoid avoid VB cord-015922-5wwy0m2k 342 8 exposure exposure NN cord-015922-5wwy0m2k 342 9 to to IN cord-015922-5wwy0m2k 342 10 pathogens pathogen NNS cord-015922-5wwy0m2k 342 11 , , , cord-015922-5wwy0m2k 342 12 especially especially RB cord-015922-5wwy0m2k 342 13 when when WRB cord-015922-5wwy0m2k 342 14 the the DT cord-015922-5wwy0m2k 342 15 immunosuppressive immunosuppressive JJ cord-015922-5wwy0m2k 342 16 therapy therapy NN cord-015922-5wwy0m2k 342 17 to to TO cord-015922-5wwy0m2k 342 18 prevent prevent VB cord-015922-5wwy0m2k 342 19 GVHD GVHD NNP cord-015922-5wwy0m2k 342 20 is be VBZ cord-015922-5wwy0m2k 342 21 the the DT cord-015922-5wwy0m2k 342 22 highest high JJS cord-015922-5wwy0m2k 342 23 . . . cord-015922-5wwy0m2k 343 1 This this DT cord-015922-5wwy0m2k 343 2 includes include VBZ cord-015922-5wwy0m2k 343 3 avoiding avoid VBG cord-015922-5wwy0m2k 343 4 gardening gardening NN cord-015922-5wwy0m2k 343 5 and and CC cord-015922-5wwy0m2k 343 6 soil soil NN cord-015922-5wwy0m2k 343 7 exposures exposure NNS cord-015922-5wwy0m2k 343 8 , , , cord-015922-5wwy0m2k 343 9 mold mold NN cord-015922-5wwy0m2k 343 10 exposures exposure NNS cord-015922-5wwy0m2k 343 11 such such JJ cord-015922-5wwy0m2k 343 12 as as IN cord-015922-5wwy0m2k 343 13 cleaning clean VBG cord-015922-5wwy0m2k 343 14 out out RP cord-015922-5wwy0m2k 343 15 damp damp JJ cord-015922-5wwy0m2k 343 16 basements basement NNS cord-015922-5wwy0m2k 343 17 or or CC cord-015922-5wwy0m2k 343 18 smoking smoking NN cord-015922-5wwy0m2k 343 19 marijuana marijuana NN cord-015922-5wwy0m2k 343 20 , , , cord-015922-5wwy0m2k 343 21 individuals individual NNS cord-015922-5wwy0m2k 343 22 with with IN cord-015922-5wwy0m2k 343 23 active active JJ cord-015922-5wwy0m2k 343 24 respiratory respiratory JJ cord-015922-5wwy0m2k 343 25 infections infection NNS cord-015922-5wwy0m2k 343 26 , , , cord-015922-5wwy0m2k 343 27 especially especially RB cord-015922-5wwy0m2k 343 28 children child NNS cord-015922-5wwy0m2k 343 29 , , , cord-015922-5wwy0m2k 343 30 and and CC cord-015922-5wwy0m2k 343 31 avoiding avoid VBG cord-015922-5wwy0m2k 343 32 enteric enteric JJ cord-015922-5wwy0m2k 343 33 pathogens pathogen NNS cord-015922-5wwy0m2k 343 34 . . . cord-015922-5wwy0m2k 344 1 Second second JJ cord-015922-5wwy0m2k 344 2 , , , cord-015922-5wwy0m2k 344 3 optimal optimal JJ cord-015922-5wwy0m2k 344 4 treatment treatment NN cord-015922-5wwy0m2k 344 5 or or CC cord-015922-5wwy0m2k 344 6 monitoring monitoring NN cord-015922-5wwy0m2k 344 7 for for IN cord-015922-5wwy0m2k 344 8 latent latent JJ cord-015922-5wwy0m2k 344 9 infections infection NNS cord-015922-5wwy0m2k 344 10 such such JJ cord-015922-5wwy0m2k 344 11 as as IN cord-015922-5wwy0m2k 344 12 herpesviruses herpesviruses NNP cord-015922-5wwy0m2k 344 13 , , , cord-015922-5wwy0m2k 344 14 hepatitis hepatitis NN cord-015922-5wwy0m2k 344 15 viruses virus NNS cord-015922-5wwy0m2k 344 16 and and CC cord-015922-5wwy0m2k 344 17 prior prior JJ cord-015922-5wwy0m2k 344 18 granulomatous granulomatous JJ cord-015922-5wwy0m2k 344 19 diseases disease NNS cord-015922-5wwy0m2k 344 20 ( ( -LRB- cord-015922-5wwy0m2k 344 21 e.g. e.g. RB cord-015922-5wwy0m2k 344 22 , , , cord-015922-5wwy0m2k 344 23 Mycobacterium Mycobacterium NNP cord-015922-5wwy0m2k 344 24 tuberculosis tuberculosis NN cord-015922-5wwy0m2k 344 25 ) ) -RRB- cord-015922-5wwy0m2k 344 26 . . . cord-015922-5wwy0m2k 345 1 Those those DT cord-015922-5wwy0m2k 345 2 patients patient NNS cord-015922-5wwy0m2k 345 3 with with IN cord-015922-5wwy0m2k 345 4 a a DT cord-015922-5wwy0m2k 345 5 positive positive JJ cord-015922-5wwy0m2k 345 6 test test NN cord-015922-5wwy0m2k 345 7 for for IN cord-015922-5wwy0m2k 345 8 latent latent JJ cord-015922-5wwy0m2k 345 9 tuberculosis tuberculosis NN cord-015922-5wwy0m2k 345 10 should should MD cord-015922-5wwy0m2k 345 11 receive receive VB cord-015922-5wwy0m2k 345 12 secondary secondary JJ cord-015922-5wwy0m2k 345 13 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 345 14 , , , cord-015922-5wwy0m2k 345 15 which which WDT cord-015922-5wwy0m2k 345 16 typically typically RB cord-015922-5wwy0m2k 345 17 is be VBZ cord-015922-5wwy0m2k 345 18 begun begin VBN cord-015922-5wwy0m2k 345 19 within within IN cord-015922-5wwy0m2k 345 20 one one CD cord-015922-5wwy0m2k 345 21 month month NN cord-015922-5wwy0m2k 345 22 post post NN cord-015922-5wwy0m2k 345 23 - - NN cord-015922-5wwy0m2k 345 24 transplantation transplantation NN cord-015922-5wwy0m2k 345 25 , , , cord-015922-5wwy0m2k 345 26 after after IN cord-015922-5wwy0m2k 345 27 the the DT cord-015922-5wwy0m2k 345 28 acute acute JJ cord-015922-5wwy0m2k 345 29 regimen regimen NN cord-015922-5wwy0m2k 345 30 toxicities toxicity NNS cord-015922-5wwy0m2k 345 31 associated associate VBN cord-015922-5wwy0m2k 345 32 with with IN cord-015922-5wwy0m2k 345 33 transplantation transplantation NN cord-015922-5wwy0m2k 345 34 have have VBP cord-015922-5wwy0m2k 345 35 subsided subside VBN cord-015922-5wwy0m2k 345 36 , , , cord-015922-5wwy0m2k 345 37 when when WRB cord-015922-5wwy0m2k 345 38 screening screening NN cord-015922-5wwy0m2k 345 39 and and CC cord-015922-5wwy0m2k 345 40 preventive preventive JJ cord-015922-5wwy0m2k 345 41 treatment treatment NN cord-015922-5wwy0m2k 345 42 have have VBP cord-015922-5wwy0m2k 345 43 not not RB cord-015922-5wwy0m2k 345 44 occurred occur VBN cord-015922-5wwy0m2k 345 45 previous previous JJ cord-015922-5wwy0m2k 345 46 to to IN cord-015922-5wwy0m2k 345 47 HSCT HSCT NNP cord-015922-5wwy0m2k 345 48 . . . cord-015922-5wwy0m2k 346 1 The the DT cord-015922-5wwy0m2k 346 2 first first JJ cord-015922-5wwy0m2k 346 3 line line NN cord-015922-5wwy0m2k 346 4 therapy therapy NN cord-015922-5wwy0m2k 346 5 for for IN cord-015922-5wwy0m2k 346 6 secondary secondary JJ cord-015922-5wwy0m2k 346 7 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 346 8 is be VBZ cord-015922-5wwy0m2k 346 9 isoniazid isoniazid JJ cord-015922-5wwy0m2k 346 10 for for IN cord-015922-5wwy0m2k 346 11 nine nine CD cord-015922-5wwy0m2k 346 12 months month NNS cord-015922-5wwy0m2k 346 13 . . . cord-015922-5wwy0m2k 347 1 However however RB cord-015922-5wwy0m2k 347 2 , , , cord-015922-5wwy0m2k 347 3 in in IN cord-015922-5wwy0m2k 347 4 patients patient NNS cord-015922-5wwy0m2k 347 5 with with IN cord-015922-5wwy0m2k 347 6 significant significant JJ cord-015922-5wwy0m2k 347 7 hepatic hepatic JJ cord-015922-5wwy0m2k 347 8 dysfunction dysfunction NN cord-015922-5wwy0m2k 347 9 or or CC cord-015922-5wwy0m2k 347 10 peripheral peripheral JJ cord-015922-5wwy0m2k 347 11 neuropathy neuropathy NN cord-015922-5wwy0m2k 347 12 alternative alternative JJ cord-015922-5wwy0m2k 347 13 regimens regimen NNS cord-015922-5wwy0m2k 347 14 need need VBP cord-015922-5wwy0m2k 347 15 to to TO cord-015922-5wwy0m2k 347 16 be be VB cord-015922-5wwy0m2k 347 17 considered consider VBN cord-015922-5wwy0m2k 347 18 . . . cord-015922-5wwy0m2k 348 1 Rifamycin Rifamycin NNP cord-015922-5wwy0m2k 348 2 - - HYPH cord-015922-5wwy0m2k 348 3 based base VBN cord-015922-5wwy0m2k 348 4 regimens regimen NNS cord-015922-5wwy0m2k 348 5 are be VBP cord-015922-5wwy0m2k 348 6 difficult difficult JJ cord-015922-5wwy0m2k 348 7 given give VBN cord-015922-5wwy0m2k 348 8 the the DT cord-015922-5wwy0m2k 348 9 potential potential JJ cord-015922-5wwy0m2k 348 10 hepatotoxicity hepatotoxicity NN cord-015922-5wwy0m2k 348 11 , , , cord-015922-5wwy0m2k 348 12 as as RB cord-015922-5wwy0m2k 348 13 well well RB cord-015922-5wwy0m2k 348 14 as as IN cord-015922-5wwy0m2k 348 15 the the DT cord-015922-5wwy0m2k 348 16 significant significant JJ cord-015922-5wwy0m2k 348 17 drug drug NN cord-015922-5wwy0m2k 348 18 interactions interaction NNS cord-015922-5wwy0m2k 348 19 , , , cord-015922-5wwy0m2k 348 20 especially especially RB cord-015922-5wwy0m2k 348 21 with with IN cord-015922-5wwy0m2k 348 22 concomitant concomitant JJ cord-015922-5wwy0m2k 348 23 use use NN cord-015922-5wwy0m2k 348 24 of of IN cord-015922-5wwy0m2k 348 25 a a DT cord-015922-5wwy0m2k 348 26 calcineurin calcineurin NN cord-015922-5wwy0m2k 348 27 or or CC cord-015922-5wwy0m2k 348 28 an an DT cord-015922-5wwy0m2k 348 29 azole azole NN cord-015922-5wwy0m2k 348 30 . . . cord-015922-5wwy0m2k 349 1 A a DT cord-015922-5wwy0m2k 349 2 quinolone quinolone NN cord-015922-5wwy0m2k 349 3 , , , cord-015922-5wwy0m2k 349 4 such such JJ cord-015922-5wwy0m2k 349 5 as as IN cord-015922-5wwy0m2k 349 6 levofloxacin levofloxacin NNS cord-015922-5wwy0m2k 349 7 , , , cord-015922-5wwy0m2k 349 8 with with IN cord-015922-5wwy0m2k 349 9 ethambutol ethambutol NNP cord-015922-5wwy0m2k 349 10 may may MD cord-015922-5wwy0m2k 349 11 be be VB cord-015922-5wwy0m2k 349 12 considered consider VBN cord-015922-5wwy0m2k 349 13 . . . cord-015922-5wwy0m2k 350 1 When when WRB cord-015922-5wwy0m2k 350 2 a a DT cord-015922-5wwy0m2k 350 3 mycobateriologically mycobateriologically RB cord-015922-5wwy0m2k 350 4 static static JJ cord-015922-5wwy0m2k 350 5 regimen regimen NN cord-015922-5wwy0m2k 350 6 is be VBZ cord-015922-5wwy0m2k 350 7 chosen choose VBN cord-015922-5wwy0m2k 350 8 , , , cord-015922-5wwy0m2k 350 9 the the DT cord-015922-5wwy0m2k 350 10 duration duration NN cord-015922-5wwy0m2k 350 11 of of IN cord-015922-5wwy0m2k 350 12 therapy therapy NN cord-015922-5wwy0m2k 350 13 often often RB cord-015922-5wwy0m2k 350 14 must must MD cord-015922-5wwy0m2k 350 15 be be VB cord-015922-5wwy0m2k 350 16 extended extend VBN cord-015922-5wwy0m2k 350 17 with with IN cord-015922-5wwy0m2k 350 18 some some DT cord-015922-5wwy0m2k 350 19 using use VBG cord-015922-5wwy0m2k 350 20 this this DT cord-015922-5wwy0m2k 350 21 combination combination NN cord-015922-5wwy0m2k 350 22 for for IN cord-015922-5wwy0m2k 350 23 18 18 CD cord-015922-5wwy0m2k 350 24 months month NNS cord-015922-5wwy0m2k 350 25 as as IN cord-015922-5wwy0m2k 350 26 secondary secondary JJ cord-015922-5wwy0m2k 350 27 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 350 28 ( ( -LRB- cord-015922-5wwy0m2k 350 29 Table Table NNP cord-015922-5wwy0m2k 350 30 19 19 CD cord-015922-5wwy0m2k 350 31 - - SYM cord-015922-5wwy0m2k 350 32 2 2 CD cord-015922-5wwy0m2k 350 33 ) ) -RRB- cord-015922-5wwy0m2k 350 34 . . . cord-015922-5wwy0m2k 351 1 Third third RB cord-015922-5wwy0m2k 351 2 , , , cord-015922-5wwy0m2k 351 3 optimizing optimize VBG cord-015922-5wwy0m2k 351 4 vaccinations vaccination NNS cord-015922-5wwy0m2k 351 5 for for IN cord-015922-5wwy0m2k 351 6 routine routine JJ cord-015922-5wwy0m2k 351 7 pathogens pathogen NNS cord-015922-5wwy0m2k 351 8 such such JJ cord-015922-5wwy0m2k 351 9 as as IN cord-015922-5wwy0m2k 351 10 diphtheria diphtheria NN cord-015922-5wwy0m2k 351 11 , , , cord-015922-5wwy0m2k 351 12 tetanus tetanus NN cord-015922-5wwy0m2k 351 13 , , , cord-015922-5wwy0m2k 351 14 pertussis pertussis NN cord-015922-5wwy0m2k 351 15 , , , cord-015922-5wwy0m2k 351 16 influenza influenza NN cord-015922-5wwy0m2k 351 17 and and CC cord-015922-5wwy0m2k 351 18 pneumococcus pneumococcus NNP cord-015922-5wwy0m2k 351 19 ( ( -LRB- cord-015922-5wwy0m2k 351 20 Table Table NNP cord-015922-5wwy0m2k 351 21 19 19 CD cord-015922-5wwy0m2k 351 22 - - SYM cord-015922-5wwy0m2k 351 23 3 3 CD cord-015922-5wwy0m2k 351 24 ) ) -RRB- cord-015922-5wwy0m2k 351 25 . . . cord-015922-5wwy0m2k 352 1 This this DT cord-015922-5wwy0m2k 352 2 optimal optimal JJ cord-015922-5wwy0m2k 352 3 timing timing NN cord-015922-5wwy0m2k 352 4 of of IN cord-015922-5wwy0m2k 352 5 re re NN cord-015922-5wwy0m2k 352 6 - - NN cord-015922-5wwy0m2k 352 7 vaccination vaccination NN cord-015922-5wwy0m2k 352 8 depends depend VBZ cord-015922-5wwy0m2k 352 9 on on IN cord-015922-5wwy0m2k 352 10 the the DT cord-015922-5wwy0m2k 352 11 nature nature NN cord-015922-5wwy0m2k 352 12 of of IN cord-015922-5wwy0m2k 352 13 the the DT cord-015922-5wwy0m2k 352 14 transplant transplant NN cord-015922-5wwy0m2k 352 15 , , , cord-015922-5wwy0m2k 352 16 with with IN cord-015922-5wwy0m2k 352 17 earlier early JJR cord-015922-5wwy0m2k 352 18 re re NN cord-015922-5wwy0m2k 352 19 - - NN cord-015922-5wwy0m2k 352 20 vaccination vaccination NN cord-015922-5wwy0m2k 352 21 schedules schedule NNS cord-015922-5wwy0m2k 352 22 being be VBG cord-015922-5wwy0m2k 352 23 considered consider VBN cord-015922-5wwy0m2k 352 24 in in IN cord-015922-5wwy0m2k 352 25 the the DT cord-015922-5wwy0m2k 352 26 nonmyeloablative nonmyeloablative JJ cord-015922-5wwy0m2k 352 27 setting setting NN cord-015922-5wwy0m2k 352 28 . . . cord-015922-5wwy0m2k 353 1 Fourth fourth JJ cord-015922-5wwy0m2k 353 2 , , , cord-015922-5wwy0m2k 353 3 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 353 4 for for IN cord-015922-5wwy0m2k 353 5 PCP PCP NNP cord-015922-5wwy0m2k 353 6 , , , cord-015922-5wwy0m2k 353 7 which which WDT cord-015922-5wwy0m2k 353 8 is be VBZ cord-015922-5wwy0m2k 353 9 typically typically RB cord-015922-5wwy0m2k 353 10 continued continue VBN cord-015922-5wwy0m2k 353 11 for for IN cord-015922-5wwy0m2k 353 12 approximately approximately RB cord-015922-5wwy0m2k 353 13 one one CD cord-015922-5wwy0m2k 353 14 year year NN cord-015922-5wwy0m2k 353 15 or or CC cord-015922-5wwy0m2k 353 16 until until IN cord-015922-5wwy0m2k 353 17 the the DT cord-015922-5wwy0m2k 353 18 immunosuppressive immunosuppressive JJ cord-015922-5wwy0m2k 353 19 medications medication NNS cord-015922-5wwy0m2k 353 20 are be VBP cord-015922-5wwy0m2k 353 21 tapered taper VBN cord-015922-5wwy0m2k 353 22 off off RP cord-015922-5wwy0m2k 353 23 . . . cord-015922-5wwy0m2k 354 1 The the DT cord-015922-5wwy0m2k 354 2 optimal optimal JJ cord-015922-5wwy0m2k 354 3 medication medication NN cord-015922-5wwy0m2k 354 4 to to TO cord-015922-5wwy0m2k 354 5 use use VB cord-015922-5wwy0m2k 354 6 for for IN cord-015922-5wwy0m2k 354 7 PCP PCP NNP cord-015922-5wwy0m2k 354 8 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 354 9 is be VBZ cord-015922-5wwy0m2k 354 10 trimethoprimsulfamethoxazole trimethoprimsulfamethoxazole NNP cord-015922-5wwy0m2k 354 11 which which WDT cord-015922-5wwy0m2k 354 12 offers offer VBZ cord-015922-5wwy0m2k 354 13 some some DT cord-015922-5wwy0m2k 354 14 protection protection NN cord-015922-5wwy0m2k 354 15 for for IN cord-015922-5wwy0m2k 354 16 a a DT cord-015922-5wwy0m2k 354 17 variety variety NN cord-015922-5wwy0m2k 354 18 of of IN cord-015922-5wwy0m2k 354 19 other other JJ cord-015922-5wwy0m2k 354 20 important important JJ cord-015922-5wwy0m2k 354 21 pathogens pathogen NNS cord-015922-5wwy0m2k 354 22 including include VBG cord-015922-5wwy0m2k 354 23 Pneumococcus Pneumococcus NNP cord-015922-5wwy0m2k 354 24 , , , cord-015922-5wwy0m2k 354 25 Hemophillus Hemophillus NNP cord-015922-5wwy0m2k 354 26 influenza influenza NN cord-015922-5wwy0m2k 354 27 , , , cord-015922-5wwy0m2k 354 28 Nocardia Nocardia NNP cord-015922-5wwy0m2k 354 29 sp sp NNP cord-015922-5wwy0m2k 354 30 . . NNP cord-015922-5wwy0m2k 354 31 , , , cord-015922-5wwy0m2k 355 1 Toxoplasma Toxoplasma NNP cord-015922-5wwy0m2k 355 2 , , , cord-015922-5wwy0m2k 355 3 Listeria Listeria NNP cord-015922-5wwy0m2k 355 4 , , , cord-015922-5wwy0m2k 355 5 Salmonella Salmonella NNP cord-015922-5wwy0m2k 355 6 sp sp NNP cord-015922-5wwy0m2k 355 7 . . NNP cord-015922-5wwy0m2k 355 8 , , , cord-015922-5wwy0m2k 355 9 and and CC cord-015922-5wwy0m2k 355 10 other other JJ cord-015922-5wwy0m2k 355 11 enteric enteric JJ cord-015922-5wwy0m2k 355 12 bacterial bacterial JJ cord-015922-5wwy0m2k 355 13 pathogens pathogen NNS cord-015922-5wwy0m2k 355 14 . . . cord-015922-5wwy0m2k 356 1 If if IN cord-015922-5wwy0m2k 356 2 trimethoprim trimethoprim NNP cord-015922-5wwy0m2k 356 3 - - HYPH cord-015922-5wwy0m2k 356 4 sulfamethoxazole sulfamethoxazole NNP cord-015922-5wwy0m2k 356 5 is be VBZ cord-015922-5wwy0m2k 356 6 not not RB cord-015922-5wwy0m2k 356 7 tolerated tolerate VBN cord-015922-5wwy0m2k 356 8 due due IN cord-015922-5wwy0m2k 356 9 to to IN cord-015922-5wwy0m2k 356 10 significant significant JJ cord-015922-5wwy0m2k 356 11 renal renal JJ cord-015922-5wwy0m2k 356 12 dysfunction dysfunction NN cord-015922-5wwy0m2k 356 13 or or CC cord-015922-5wwy0m2k 356 14 bone bone NN cord-015922-5wwy0m2k 356 15 marrow marrow NN cord-015922-5wwy0m2k 356 16 suppression suppression NN cord-015922-5wwy0m2k 356 17 , , , cord-015922-5wwy0m2k 356 18 then then RB cord-015922-5wwy0m2k 356 19 alternative alternative JJ cord-015922-5wwy0m2k 356 20 agents agent NNS cord-015922-5wwy0m2k 356 21 for for IN cord-015922-5wwy0m2k 356 22 PCP PCP NNP cord-015922-5wwy0m2k 356 23 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 356 24 include include VBP cord-015922-5wwy0m2k 356 25 dapsone dapsone NN cord-015922-5wwy0m2k 356 26 , , , cord-015922-5wwy0m2k 356 27 atovaquone atovaquone NNP cord-015922-5wwy0m2k 356 28 or or CC cord-015922-5wwy0m2k 356 29 aerosolized aerosolize VBN cord-015922-5wwy0m2k 356 30 pentamidine pentamidine NN cord-015922-5wwy0m2k 356 31 ; ; : cord-015922-5wwy0m2k 356 32 however however RB cord-015922-5wwy0m2k 356 33 , , , cord-015922-5wwy0m2k 356 34 none none NN cord-015922-5wwy0m2k 356 35 of of IN cord-015922-5wwy0m2k 356 36 these these DT cord-015922-5wwy0m2k 356 37 second second JJ cord-015922-5wwy0m2k 356 38 line line NN cord-015922-5wwy0m2k 356 39 agents agent NNS cord-015922-5wwy0m2k 356 40 afford afford VBP cord-015922-5wwy0m2k 356 41 the the DT cord-015922-5wwy0m2k 356 42 broad broad JJ cord-015922-5wwy0m2k 356 43 microbial microbial JJ cord-015922-5wwy0m2k 356 44 protection protection NN cord-015922-5wwy0m2k 356 45 which which WDT cord-015922-5wwy0m2k 356 46 trimethoprim trimethoprim NNP cord-015922-5wwy0m2k 356 47 - - HYPH cord-015922-5wwy0m2k 356 48 sulfamethoxazole sulfamethoxazole NNP cord-015922-5wwy0m2k 356 49 affords afford VBZ cord-015922-5wwy0m2k 356 50 . . . cord-015922-5wwy0m2k 357 1 And and CC cord-015922-5wwy0m2k 357 2 lastly lastly RB cord-015922-5wwy0m2k 357 3 , , , cord-015922-5wwy0m2k 357 4 herpes herpes NN cord-015922-5wwy0m2k 357 5 group group NN cord-015922-5wwy0m2k 357 6 viral viral JJ cord-015922-5wwy0m2k 357 7 prevention prevention NN cord-015922-5wwy0m2k 357 8 which which WDT cord-015922-5wwy0m2k 357 9 should should MD cord-015922-5wwy0m2k 357 10 include include VB cord-015922-5wwy0m2k 357 11 acyclovir acyclovir NNP cord-015922-5wwy0m2k 357 12 to to TO cord-015922-5wwy0m2k 357 13 prevent prevent VB cord-015922-5wwy0m2k 357 14 HSV HSV NNP cord-015922-5wwy0m2k 357 15 and and CC cord-015922-5wwy0m2k 357 16 VZV VZV NNP cord-015922-5wwy0m2k 357 17 and and CC cord-015922-5wwy0m2k 357 18 systematic systematic JJ cord-015922-5wwy0m2k 357 19 monitoring monitoring NN cord-015922-5wwy0m2k 357 20 for for IN cord-015922-5wwy0m2k 357 21 CMV CMV NNP cord-015922-5wwy0m2k 357 22 , , , cord-015922-5wwy0m2k 357 23 in in IN cord-015922-5wwy0m2k 357 24 the the DT cord-015922-5wwy0m2k 357 25 allogeneic allogeneic NN cord-015922-5wwy0m2k 357 26 setting setting NN cord-015922-5wwy0m2k 357 27 , , , cord-015922-5wwy0m2k 357 28 with with IN cord-015922-5wwy0m2k 357 29 early early JJ cord-015922-5wwy0m2k 357 30 use use NN cord-015922-5wwy0m2k 357 31 of of IN cord-015922-5wwy0m2k 357 32 a a DT cord-015922-5wwy0m2k 357 33 CMV CMV NNP cord-015922-5wwy0m2k 357 34 active active JJ cord-015922-5wwy0m2k 357 35 antiviral antiviral JJ cord-015922-5wwy0m2k 357 36 if if IN cord-015922-5wwy0m2k 357 37 evidence evidence NN cord-015922-5wwy0m2k 357 38 for for IN cord-015922-5wwy0m2k 357 39 CMV CMV NNP cord-015922-5wwy0m2k 357 40 activation activation NN cord-015922-5wwy0m2k 357 41 or or CC cord-015922-5wwy0m2k 357 42 disease disease NN cord-015922-5wwy0m2k 357 43 is be VBZ cord-015922-5wwy0m2k 357 44 observed observe VBN cord-015922-5wwy0m2k 357 45 . . . cord-015922-5wwy0m2k 358 1 Prophylaxis prophylaxis NN cord-015922-5wwy0m2k 358 2 must must MD cord-015922-5wwy0m2k 358 3 be be VB cord-015922-5wwy0m2k 358 4 re re VBN cord-015922-5wwy0m2k 358 5 - - VBN cord-015922-5wwy0m2k 358 6 assessed assess VBN cord-015922-5wwy0m2k 358 7 in in IN cord-015922-5wwy0m2k 358 8 the the DT cord-015922-5wwy0m2k 358 9 setting setting NN cord-015922-5wwy0m2k 358 10 of of IN cord-015922-5wwy0m2k 358 11 persistent persistent JJ cord-015922-5wwy0m2k 358 12 or or CC cord-015922-5wwy0m2k 358 13 augmented augment VBN cord-015922-5wwy0m2k 358 14 immunosuppression immunosuppression NN cord-015922-5wwy0m2k 358 15 , , , cord-015922-5wwy0m2k 358 16 such such JJ cord-015922-5wwy0m2k 358 17 as as IN cord-015922-5wwy0m2k 358 18 in in IN cord-015922-5wwy0m2k 358 19 the the DT cord-015922-5wwy0m2k 358 20 setting setting NN cord-015922-5wwy0m2k 358 21 of of IN cord-015922-5wwy0m2k 358 22 clinically clinically RB cord-015922-5wwy0m2k 358 23 significant significant JJ cord-015922-5wwy0m2k 358 24 GVHD GVHD NNP cord-015922-5wwy0m2k 358 25 , , , cord-015922-5wwy0m2k 358 26 regardless regardless RB cord-015922-5wwy0m2k 358 27 of of IN cord-015922-5wwy0m2k 358 28 time time NN cord-015922-5wwy0m2k 358 29 since since IN cord-015922-5wwy0m2k 358 30 HSCT HSCT NNP cord-015922-5wwy0m2k 358 31 . . . cord-015922-5wwy0m2k 359 1 Medication medication NN cord-015922-5wwy0m2k 359 2 doses dose NNS cord-015922-5wwy0m2k 359 3 may may MD cord-015922-5wwy0m2k 359 4 need need VB cord-015922-5wwy0m2k 359 5 to to TO cord-015922-5wwy0m2k 359 6 be be VB cord-015922-5wwy0m2k 359 7 adjusted adjust VBN cord-015922-5wwy0m2k 359 8 for for IN cord-015922-5wwy0m2k 359 9 renal renal JJ cord-015922-5wwy0m2k 359 10 dysfunction dysfunction NN cord-015922-5wwy0m2k 359 11 . . . cord-015922-5wwy0m2k 360 1 * * NFP cord-015922-5wwy0m2k 360 2 Trimethoprim Trimethoprim NNP cord-015922-5wwy0m2k 360 3 - - HYPH cord-015922-5wwy0m2k 360 4 sulfamethoxazole sulfamethoxazole NNP cord-015922-5wwy0m2k 360 5 affords afford VBZ cord-015922-5wwy0m2k 360 6 modest modest JJ cord-015922-5wwy0m2k 360 7 protection protection NN cord-015922-5wwy0m2k 360 8 for for IN cord-015922-5wwy0m2k 360 9 a a DT cord-015922-5wwy0m2k 360 10 broad broad JJ cord-015922-5wwy0m2k 360 11 array array NN cord-015922-5wwy0m2k 360 12 of of IN cord-015922-5wwy0m2k 360 13 potential potential JJ cord-015922-5wwy0m2k 360 14 environmental environmental JJ cord-015922-5wwy0m2k 360 15 and and CC cord-015922-5wwy0m2k 360 16 community community NN cord-015922-5wwy0m2k 360 17 pathogens pathogen NNS cord-015922-5wwy0m2k 360 18 including include VBG cord-015922-5wwy0m2k 360 19 : : : cord-015922-5wwy0m2k 361 1 Nocardia Nocardia NNP cord-015922-5wwy0m2k 361 2 sp sp NN cord-015922-5wwy0m2k 361 3 , , , cord-015922-5wwy0m2k 361 4 toxoplasmosis toxoplasmosis NN cord-015922-5wwy0m2k 361 5 , , , cord-015922-5wwy0m2k 361 6 pneumococci pneumococcus NNS cord-015922-5wwy0m2k 361 7 , , , cord-015922-5wwy0m2k 361 8 H H NNP cord-015922-5wwy0m2k 361 9 influenza influenza NN cord-015922-5wwy0m2k 361 10 , , , cord-015922-5wwy0m2k 361 11 listeria listeria NN cord-015922-5wwy0m2k 361 12 , , , cord-015922-5wwy0m2k 361 13 shigella shigella NNP cord-015922-5wwy0m2k 361 14 , , , cord-015922-5wwy0m2k 361 15 and and CC cord-015922-5wwy0m2k 361 16 slamonella slamonella NNP cord-015922-5wwy0m2k 361 17 sp sp NNP cord-015922-5wwy0m2k 361 18 . . . cord-015922-5wwy0m2k 362 1 * * NFP cord-015922-5wwy0m2k 362 2 * * NFP cord-015922-5wwy0m2k 362 3 Alternatively alternatively RB cord-015922-5wwy0m2k 362 4 preemptive preemptive JJ cord-015922-5wwy0m2k 362 5 monitoring monitoring NN cord-015922-5wwy0m2k 362 6 with with IN cord-015922-5wwy0m2k 362 7 serial serial JJ cord-015922-5wwy0m2k 362 8 viral viral JJ cord-015922-5wwy0m2k 362 9 antigen antigen NN cord-015922-5wwy0m2k 362 10 or or CC cord-015922-5wwy0m2k 362 11 viral viral JJ cord-015922-5wwy0m2k 362 12 load load NN cord-015922-5wwy0m2k 362 13 assays assay NNS cord-015922-5wwy0m2k 362 14 can can MD cord-015922-5wwy0m2k 362 15 be be VB cord-015922-5wwy0m2k 362 16 considered consider VBN cord-015922-5wwy0m2k 362 17 . . . cord-015922-5wwy0m2k 363 1 * * NFP cord-015922-5wwy0m2k 363 2 * * NFP cord-015922-5wwy0m2k 363 3 * * NFP cord-015922-5wwy0m2k 363 4 For for IN cord-015922-5wwy0m2k 363 5 those those DT cord-015922-5wwy0m2k 363 6 with with IN cord-015922-5wwy0m2k 363 7 evidence evidence NN cord-015922-5wwy0m2k 363 8 of of IN cord-015922-5wwy0m2k 363 9 prior prior JJ cord-015922-5wwy0m2k 363 10 HBV HBV NNP cord-015922-5wwy0m2k 363 11 infection infection NN cord-015922-5wwy0m2k 363 12 ( ( -LRB- cord-015922-5wwy0m2k 363 13 e.g. e.g. RB cord-015922-5wwy0m2k 363 14 , , , cord-015922-5wwy0m2k 363 15 Hepatitis Hepatitis NNP cord-015922-5wwy0m2k 363 16 B B NNP cord-015922-5wwy0m2k 363 17 core core NN cord-015922-5wwy0m2k 363 18 antibody antibody NN cord-015922-5wwy0m2k 363 19 positive positive JJ cord-015922-5wwy0m2k 363 20 ) ) -RRB- cord-015922-5wwy0m2k 363 21 , , , cord-015922-5wwy0m2k 363 22 consider consider VB cord-015922-5wwy0m2k 363 23 monitoring monitor VBG cord-015922-5wwy0m2k 363 24 HBV HBV NNP cord-015922-5wwy0m2k 363 25 viral viral JJ cord-015922-5wwy0m2k 363 26 load load NN cord-015922-5wwy0m2k 363 27 for for IN cord-015922-5wwy0m2k 363 28 evidence evidence NN cord-015922-5wwy0m2k 363 29 of of IN cord-015922-5wwy0m2k 363 30 reactivation reactivation NN cord-015922-5wwy0m2k 363 31 periodically periodically RB cord-015922-5wwy0m2k 363 32 . . . cord-015922-5wwy0m2k 364 1 If if IN cord-015922-5wwy0m2k 364 2 reactivation reactivation NN cord-015922-5wwy0m2k 364 3 is be VBZ cord-015922-5wwy0m2k 364 4 detected detect VBN cord-015922-5wwy0m2k 364 5 then then RB cord-015922-5wwy0m2k 364 6 consider consider VB cord-015922-5wwy0m2k 364 7 treatment treatment NN cord-015922-5wwy0m2k 364 8 if if IN cord-015922-5wwy0m2k 364 9 persistent persistent JJ cord-015922-5wwy0m2k 364 10 HBV HBV NNP cord-015922-5wwy0m2k 364 11 viremia viremia NN cord-015922-5wwy0m2k 364 12 detected detect VBD cord-015922-5wwy0m2k 364 13 . . . cord-015922-5wwy0m2k 365 1 Specific specific JJ cord-015922-5wwy0m2k 365 2 HBV HBV NNP cord-015922-5wwy0m2k 365 3 antiviral antiviral JJ cord-015922-5wwy0m2k 365 4 therapy therapy NN cord-015922-5wwy0m2k 365 5 is be VBZ cord-015922-5wwy0m2k 365 6 discussed discuss VBN cord-015922-5wwy0m2k 365 7 in in IN cord-015922-5wwy0m2k 365 8 the the DT cord-015922-5wwy0m2k 365 9 text text NN cord-015922-5wwy0m2k 365 10 . . . cord-015922-5wwy0m2k 366 1 * * NFP cord-015922-5wwy0m2k 366 2 * * NFP cord-015922-5wwy0m2k 366 3 * * NFP cord-015922-5wwy0m2k 366 4 * * NFP cord-015922-5wwy0m2k 366 5 Pre pre JJ cord-015922-5wwy0m2k 366 6 - - JJ cord-015922-5wwy0m2k 366 7 transplant transplant JJ cord-015922-5wwy0m2k 366 8 secondary secondary JJ cord-015922-5wwy0m2k 366 9 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 366 10 for for IN cord-015922-5wwy0m2k 366 11 MTb MTb NNS cord-015922-5wwy0m2k 366 12 is be VBZ cord-015922-5wwy0m2k 366 13 preferred prefer VBN cord-015922-5wwy0m2k 366 14 . . . cord-015922-5wwy0m2k 367 1 * * NFP cord-015922-5wwy0m2k 367 2 * * NFP cord-015922-5wwy0m2k 367 3 * * NFP cord-015922-5wwy0m2k 367 4 * * NFP cord-015922-5wwy0m2k 367 5 * * NFP cord-015922-5wwy0m2k 367 6 Decision decision NN cord-015922-5wwy0m2k 367 7 for for IN cord-015922-5wwy0m2k 367 8 systemic systemic JJ cord-015922-5wwy0m2k 367 9 azole azole NNP cord-015922-5wwy0m2k 367 10 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 367 11 should should MD cord-015922-5wwy0m2k 367 12 be be VB cord-015922-5wwy0m2k 367 13 based base VBN cord-015922-5wwy0m2k 367 14 on on IN cord-015922-5wwy0m2k 367 15 local local JJ cord-015922-5wwy0m2k 367 16 epidemiology epidemiology NN cord-015922-5wwy0m2k 367 17 of of IN cord-015922-5wwy0m2k 367 18 invasive invasive JJ cord-015922-5wwy0m2k 367 19 fungal fungal JJ cord-015922-5wwy0m2k 367 20 infections infection NNS cord-015922-5wwy0m2k 367 21 . . . cord-015922-5wwy0m2k 368 1 Consider consider VB cord-015922-5wwy0m2k 368 2 posaconazole posaconazole NN cord-015922-5wwy0m2k 368 3 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 368 4 in in IN cord-015922-5wwy0m2k 368 5 the the DT cord-015922-5wwy0m2k 368 6 setting setting NN cord-015922-5wwy0m2k 368 7 of of IN cord-015922-5wwy0m2k 368 8 significant significant JJ cord-015922-5wwy0m2k 368 9 GVHD GVHD NNP cord-015922-5wwy0m2k 368 10 ( ( -LRB- cord-015922-5wwy0m2k 368 11 e.g. e.g. RB cord-015922-5wwy0m2k 368 12 , , , cord-015922-5wwy0m2k 368 13 Grade Grade NNP cord-015922-5wwy0m2k 368 14 3 3 CD cord-015922-5wwy0m2k 368 15 or or CC cord-015922-5wwy0m2k 368 16 4 4 CD cord-015922-5wwy0m2k 368 17 ) ) -RRB- cord-015922-5wwy0m2k 368 18 and and CC cord-015922-5wwy0m2k 368 19 its -PRON- PRP$ cord-015922-5wwy0m2k 368 20 therapy therapy NN cord-015922-5wwy0m2k 368 21 . . . cord-015922-5wwy0m2k 369 1 Drug drug NN cord-015922-5wwy0m2k 369 2 interactions interaction NNS cord-015922-5wwy0m2k 369 3 must must MD cord-015922-5wwy0m2k 369 4 be be VB cord-015922-5wwy0m2k 369 5 carefully carefully RB cord-015922-5wwy0m2k 369 6 managed manage VBN cord-015922-5wwy0m2k 369 7 both both CC cord-015922-5wwy0m2k 369 8 with with IN cord-015922-5wwy0m2k 369 9 initiation initiation NN cord-015922-5wwy0m2k 369 10 and and CC cord-015922-5wwy0m2k 369 11 cessation cessation NN cord-015922-5wwy0m2k 369 12 of of IN cord-015922-5wwy0m2k 369 13 azole azole NNP cord-015922-5wwy0m2k 369 14 therapy therapy NN cord-015922-5wwy0m2k 369 15 . . . cord-015922-5wwy0m2k 370 1 An an DT cord-015922-5wwy0m2k 370 2 important important JJ cord-015922-5wwy0m2k 370 3 aspect aspect NN cord-015922-5wwy0m2k 370 4 of of IN cord-015922-5wwy0m2k 370 5 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 370 6 therapy therapy NN cord-015922-5wwy0m2k 370 7 in in IN cord-015922-5wwy0m2k 370 8 the the DT cord-015922-5wwy0m2k 370 9 HSCT HSCT NNP cord-015922-5wwy0m2k 370 10 patient patient NN cord-015922-5wwy0m2k 370 11 is be VBZ cord-015922-5wwy0m2k 370 12 the the DT cord-015922-5wwy0m2k 370 13 management management NN cord-015922-5wwy0m2k 370 14 of of IN cord-015922-5wwy0m2k 370 15 drug drug NN cord-015922-5wwy0m2k 370 16 interactions interaction NNS cord-015922-5wwy0m2k 370 17 , , , cord-015922-5wwy0m2k 370 18 especially especially RB cord-015922-5wwy0m2k 370 19 between between IN cord-015922-5wwy0m2k 370 20 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 370 21 agents agent NNS cord-015922-5wwy0m2k 370 22 ( ( -LRB- cord-015922-5wwy0m2k 370 23 e.g. e.g. RB cord-015922-5wwy0m2k 370 24 , , , cord-015922-5wwy0m2k 370 25 azoles azole NNS cord-015922-5wwy0m2k 370 26 , , , cord-015922-5wwy0m2k 370 27 macrolides macrolides NNP cord-015922-5wwy0m2k 370 28 ) ) -RRB- cord-015922-5wwy0m2k 370 29 and and CC cord-015922-5wwy0m2k 370 30 the the DT cord-015922-5wwy0m2k 370 31 immunosuppressive immunosuppressive JJ cord-015922-5wwy0m2k 370 32 medications medication NNS cord-015922-5wwy0m2k 370 33 ( ( -LRB- cord-015922-5wwy0m2k 370 34 e.g. e.g. RB cord-015922-5wwy0m2k 370 35 , , , cord-015922-5wwy0m2k 370 36 calcineurin calcineurin NNP cord-015922-5wwy0m2k 370 37 inhibitors inhibitor NNS cord-015922-5wwy0m2k 370 38 , , , cord-015922-5wwy0m2k 370 39 sirolimus sirolimus NNP cord-015922-5wwy0m2k 370 40 ) ) -RRB- cord-015922-5wwy0m2k 370 41 used use VBD cord-015922-5wwy0m2k 370 42 to to TO cord-015922-5wwy0m2k 370 43 prevent prevent VB cord-015922-5wwy0m2k 370 44 and and CC cord-015922-5wwy0m2k 370 45 treat treat VB cord-015922-5wwy0m2k 370 46 GVHD GVHD NNP cord-015922-5wwy0m2k 370 47 . . . cord-015922-5wwy0m2k 371 1 There there EX cord-015922-5wwy0m2k 371 2 are be VBP cord-015922-5wwy0m2k 371 3 three three CD cord-015922-5wwy0m2k 371 4 important important JJ cord-015922-5wwy0m2k 371 5 categories category NNS cord-015922-5wwy0m2k 371 6 of of IN cord-015922-5wwy0m2k 371 7 interaction interaction NN cord-015922-5wwy0m2k 371 8 to to TO cord-015922-5wwy0m2k 371 9 pay pay VB cord-015922-5wwy0m2k 371 10 particular particular JJ cord-015922-5wwy0m2k 371 11 attention attention NN cord-015922-5wwy0m2k 371 12 to to IN cord-015922-5wwy0m2k 371 13 , , , cord-015922-5wwy0m2k 371 14 two two CD cord-015922-5wwy0m2k 371 15 of of IN cord-015922-5wwy0m2k 371 16 which which WDT cord-015922-5wwy0m2k 371 17 are be VBP cord-015922-5wwy0m2k 371 18 related relate VBN cord-015922-5wwy0m2k 371 19 to to IN cord-015922-5wwy0m2k 371 20 the the DT cord-015922-5wwy0m2k 371 21 major major JJ cord-015922-5wwy0m2k 371 22 route route NN cord-015922-5wwy0m2k 371 23 of of IN cord-015922-5wwy0m2k 371 24 drug drug NN cord-015922-5wwy0m2k 371 25 metabolism metabolism NN cord-015922-5wwy0m2k 371 26 for for IN cord-015922-5wwy0m2k 371 27 the the DT cord-015922-5wwy0m2k 371 28 calcineurin calcineurin NNP cord-015922-5wwy0m2k 371 29 inhibitors inhibitor NNS cord-015922-5wwy0m2k 371 30 , , , cord-015922-5wwy0m2k 371 31 hepatic hepatic JJ cord-015922-5wwy0m2k 371 32 cytochrome cytochrome NN cord-015922-5wwy0m2k 371 33 P450 p450 JJ cord-015922-5wwy0m2k 371 34 enzymatic enzymatic JJ cord-015922-5wwy0m2k 371 35 metabolism metabolism NN cord-015922-5wwy0m2k 371 36 . . . cord-015922-5wwy0m2k 372 1 These these DT cord-015922-5wwy0m2k 372 2 interactions interaction NNS cord-015922-5wwy0m2k 372 3 are be VBP cord-015922-5wwy0m2k 372 4 as as IN cord-015922-5wwy0m2k 372 5 follows follow VBZ cord-015922-5wwy0m2k 372 6 : : : cord-015922-5wwy0m2k 372 7 1 1 LS cord-015922-5wwy0m2k 372 8 ) ) -RRB- cord-015922-5wwy0m2k 372 9 certain certain JJ cord-015922-5wwy0m2k 372 10 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 372 11 agents agent NNS cord-015922-5wwy0m2k 372 12 ( ( -LRB- cord-015922-5wwy0m2k 372 13 most most RBS cord-015922-5wwy0m2k 372 14 notably notably RB cord-015922-5wwy0m2k 372 15 the the DT cord-015922-5wwy0m2k 372 16 macrolides macrolide NNS cord-015922-5wwy0m2k 372 17 [ [ -LRB- cord-015922-5wwy0m2k 372 18 eryth eryth NN cord-015922-5wwy0m2k 372 19 romycin romycin NNS cord-015922-5wwy0m2k 372 20 > > XX cord-015922-5wwy0m2k 373 1 clarithromycin clarithromycin NNP cord-015922-5wwy0m2k 374 1 > > XX cord-015922-5wwy0m2k 375 1 azithromycin azithromycin NNP cord-015922-5wwy0m2k 375 2 ] ] -RRB- cord-015922-5wwy0m2k 375 3 and and CC cord-015922-5wwy0m2k 375 4 the the DT cord-015922-5wwy0m2k 375 5 azoles azole NNS cord-015922-5wwy0m2k 375 6 [ [ -LRB- cord-015922-5wwy0m2k 375 7 ketoconazole ketoconazole RB cord-015922-5wwy0m2k 375 8 > > XX cord-015922-5wwy0m2k 376 1 itraco itraco NNP cord-015922-5wwy0m2k 376 2 nazole nazole NNP cord-015922-5wwy0m2k 377 1 > > XX cord-015922-5wwy0m2k 378 1 voriconazole voriconazole NNP cord-015922-5wwy0m2k 378 2 > > XX cord-015922-5wwy0m2k 378 3 fluconazole fluconazole NNP cord-015922-5wwy0m2k 378 4 ] ] -RRB- cord-015922-5wwy0m2k 378 5 ) ) -RRB- cord-015922-5wwy0m2k 378 6 will will MD cord-015922-5wwy0m2k 378 7 downregulate downregulate VB cord-015922-5wwy0m2k 378 8 the the DT cord-015922-5wwy0m2k 378 9 metabolism metabolism NN cord-015922-5wwy0m2k 378 10 of of IN cord-015922-5wwy0m2k 378 11 the the DT cord-015922-5wwy0m2k 378 12 calcineurin calcineurin NN cord-015922-5wwy0m2k 378 13 inhibitors inhibitor NNS cord-015922-5wwy0m2k 378 14 , , , cord-015922-5wwy0m2k 378 15 resulting result VBG cord-015922-5wwy0m2k 378 16 in in IN cord-015922-5wwy0m2k 378 17 elevated elevated JJ cord-015922-5wwy0m2k 378 18 blood blood NN cord-015922-5wwy0m2k 378 19 levels level NNS cord-015922-5wwy0m2k 378 20 of of IN cord-015922-5wwy0m2k 378 21 active active JJ cord-015922-5wwy0m2k 378 22 drug drug NN cord-015922-5wwy0m2k 378 23 , , , cord-015922-5wwy0m2k 378 24 and and CC cord-015922-5wwy0m2k 378 25 an an DT cord-015922-5wwy0m2k 378 26 increased increase VBN cord-015922-5wwy0m2k 378 27 risk risk NN cord-015922-5wwy0m2k 378 28 of of IN cord-015922-5wwy0m2k 378 29 nephrotoxicity nephrotoxicity NN cord-015922-5wwy0m2k 378 30 , , , cord-015922-5wwy0m2k 378 31 as as RB cord-015922-5wwy0m2k 378 32 well well RB cord-015922-5wwy0m2k 378 33 as as IN cord-015922-5wwy0m2k 378 34 over over IN cord-015922-5wwy0m2k 378 35 - - HYPH cord-015922-5wwy0m2k 378 36 immunosuppression immunosuppression NN cord-015922-5wwy0m2k 378 37 and and CC cord-015922-5wwy0m2k 378 38 an an DT cord-015922-5wwy0m2k 378 39 increased increase VBN cord-015922-5wwy0m2k 378 40 incidence incidence NN cord-015922-5wwy0m2k 378 41 of of IN cord-015922-5wwy0m2k 378 42 opportunistic opportunistic JJ cord-015922-5wwy0m2k 378 43 infection infection NN cord-015922-5wwy0m2k 378 44 ; ; : cord-015922-5wwy0m2k 379 1 2 2 LS cord-015922-5wwy0m2k 379 2 ) ) -RRB- cord-015922-5wwy0m2k 379 3 certain certain JJ cord-015922-5wwy0m2k 379 4 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 379 5 agents agent NNS cord-015922-5wwy0m2k 379 6 ( ( -LRB- cord-015922-5wwy0m2k 379 7 such such JJ cord-015922-5wwy0m2k 379 8 as as IN cord-015922-5wwy0m2k 379 9 rifampin rifampin NN cord-015922-5wwy0m2k 379 10 and and CC cord-015922-5wwy0m2k 379 11 rifabutin rifabutin NNS cord-015922-5wwy0m2k 379 12 ) ) -RRB- cord-015922-5wwy0m2k 379 13 upregulate upregulate VBP cord-015922-5wwy0m2k 379 14 metabolism metabolism NN cord-015922-5wwy0m2k 379 15 of of IN cord-015922-5wwy0m2k 379 16 the the DT cord-015922-5wwy0m2k 379 17 calcineurin calcineurin NNP cord-015922-5wwy0m2k 379 18 inhibitors inhibitor NNS cord-015922-5wwy0m2k 379 19 , , , cord-015922-5wwy0m2k 379 20 leading lead VBG cord-015922-5wwy0m2k 379 21 to to IN cord-015922-5wwy0m2k 379 22 a a DT cord-015922-5wwy0m2k 379 23 fall fall NN cord-015922-5wwy0m2k 379 24 in in IN cord-015922-5wwy0m2k 379 25 blood blood NN cord-015922-5wwy0m2k 379 26 levels level NNS cord-015922-5wwy0m2k 379 27 and and CC cord-015922-5wwy0m2k 379 28 an an DT cord-015922-5wwy0m2k 379 29 increased increase VBN cord-015922-5wwy0m2k 379 30 risk risk NN cord-015922-5wwy0m2k 379 31 of of IN cord-015922-5wwy0m2k 379 32 GvHD GvHD NNP cord-015922-5wwy0m2k 379 33 , , , cord-015922-5wwy0m2k 379 34 and and CC cord-015922-5wwy0m2k 379 35 3 3 LS cord-015922-5wwy0m2k 379 36 ) ) -RRB- cord-015922-5wwy0m2k 379 37 therapeutic therapeutic JJ cord-015922-5wwy0m2k 379 38 blood blood NN cord-015922-5wwy0m2k 379 39 levels level NNS cord-015922-5wwy0m2k 379 40 of of IN cord-015922-5wwy0m2k 379 41 the the DT cord-015922-5wwy0m2k 379 42 calcineurin calcineurin NN cord-015922-5wwy0m2k 379 43 inhibitors inhibitor NNS cord-015922-5wwy0m2k 379 44 , , , cord-015922-5wwy0m2k 379 45 when when WRB cord-015922-5wwy0m2k 379 46 combined combine VBN cord-015922-5wwy0m2k 379 47 with with IN cord-015922-5wwy0m2k 379 48 such such JJ cord-015922-5wwy0m2k 379 49 drugs drug NNS cord-015922-5wwy0m2k 379 50 as as IN cord-015922-5wwy0m2k 379 51 amphotericin amphotericin NNS cord-015922-5wwy0m2k 379 52 B b NN cord-015922-5wwy0m2k 379 53 , , , cord-015922-5wwy0m2k 379 54 aminoglycosides aminoglycoside NNS cord-015922-5wwy0m2k 379 55 and and CC cord-015922-5wwy0m2k 379 56 vancomycin vancomycin NN cord-015922-5wwy0m2k 379 57 , , , cord-015922-5wwy0m2k 379 58 can can MD cord-015922-5wwy0m2k 379 59 cause cause VB cord-015922-5wwy0m2k 379 60 significant significant JJ cord-015922-5wwy0m2k 379 61 renal renal JJ cord-015922-5wwy0m2k 379 62 toxicity toxicity NN cord-015922-5wwy0m2k 379 63 . . . cord-015922-5wwy0m2k 380 1 HSCT HSCT NNP cord-015922-5wwy0m2k 380 2 has have VBZ cord-015922-5wwy0m2k 380 3 become become VBN cord-015922-5wwy0m2k 380 4 one one CD cord-015922-5wwy0m2k 380 5 of of IN cord-015922-5wwy0m2k 380 6 the the DT cord-015922-5wwy0m2k 380 7 great great JJ cord-015922-5wwy0m2k 380 8 success success NN cord-015922-5wwy0m2k 380 9 stories story NNS cord-015922-5wwy0m2k 380 10 of of IN cord-015922-5wwy0m2k 380 11 modern modern JJ cord-015922-5wwy0m2k 380 12 medicine medicine NN cord-015922-5wwy0m2k 380 13 . . . cord-015922-5wwy0m2k 381 1 It -PRON- PRP cord-015922-5wwy0m2k 381 2 is be VBZ cord-015922-5wwy0m2k 381 3 the the DT cord-015922-5wwy0m2k 381 4 therapy therapy NN cord-015922-5wwy0m2k 381 5 of of IN cord-015922-5wwy0m2k 381 6 choice choice NN cord-015922-5wwy0m2k 381 7 for for IN cord-015922-5wwy0m2k 381 8 an an DT cord-015922-5wwy0m2k 381 9 increasing increase VBG cord-015922-5wwy0m2k 381 10 number number NN cord-015922-5wwy0m2k 381 11 of of IN cord-015922-5wwy0m2k 381 12 conditions condition NNS cord-015922-5wwy0m2k 381 13 , , , cord-015922-5wwy0m2k 381 14 including include VBG cord-015922-5wwy0m2k 381 15 a a DT cord-015922-5wwy0m2k 381 16 variety variety NN cord-015922-5wwy0m2k 381 17 of of IN cord-015922-5wwy0m2k 381 18 cancers cancer NNS cord-015922-5wwy0m2k 381 19 , , , cord-015922-5wwy0m2k 381 20 bone bone NN cord-015922-5wwy0m2k 381 21 marrow marrow NN cord-015922-5wwy0m2k 381 22 failure failure NN cord-015922-5wwy0m2k 381 23 states state NNS cord-015922-5wwy0m2k 381 24 , , , cord-015922-5wwy0m2k 381 25 congenital congenital JJ cord-015922-5wwy0m2k 381 26 immunodeficiencies immunodeficiency NNS cord-015922-5wwy0m2k 381 27 , , , cord-015922-5wwy0m2k 381 28 metabolic metabolic JJ cord-015922-5wwy0m2k 381 29 disorders disorder NNS cord-015922-5wwy0m2k 381 30 and and CC cord-015922-5wwy0m2k 381 31 even even RB cord-015922-5wwy0m2k 381 32 as as IN cord-015922-5wwy0m2k 381 33 a a DT cord-015922-5wwy0m2k 381 34 means means NN cord-015922-5wwy0m2k 381 35 for for IN cord-015922-5wwy0m2k 381 36 introducing introduce VBG cord-015922-5wwy0m2k 381 37 new new JJ cord-015922-5wwy0m2k 381 38 genes gene NNS cord-015922-5wwy0m2k 381 39 . . . cord-015922-5wwy0m2k 382 1 The the DT cord-015922-5wwy0m2k 382 2 major major JJ cord-015922-5wwy0m2k 382 3 hurdle hurdle NN cord-015922-5wwy0m2k 382 4 in in IN cord-015922-5wwy0m2k 382 5 most most JJS cord-015922-5wwy0m2k 382 6 of of IN cord-015922-5wwy0m2k 382 7 these these DT cord-015922-5wwy0m2k 382 8 attempts attempt NNS cord-015922-5wwy0m2k 382 9 , , , cord-015922-5wwy0m2k 382 10 however however RB cord-015922-5wwy0m2k 382 11 , , , cord-015922-5wwy0m2k 382 12 remains remain VBZ cord-015922-5wwy0m2k 382 13 infection infection NN cord-015922-5wwy0m2k 382 14 . . . cord-015922-5wwy0m2k 383 1 Bacterial bacterial JJ cord-015922-5wwy0m2k 383 2 and and CC cord-015922-5wwy0m2k 383 3 fungal fungal JJ cord-015922-5wwy0m2k 383 4 sepsis sepsis NN cord-015922-5wwy0m2k 383 5 , , , cord-015922-5wwy0m2k 383 6 as as RB cord-015922-5wwy0m2k 383 7 well well RB cord-015922-5wwy0m2k 383 8 as as IN cord-015922-5wwy0m2k 383 9 herpes herpes NN cord-015922-5wwy0m2k 383 10 group group NN cord-015922-5wwy0m2k 383 11 viral viral JJ cord-015922-5wwy0m2k 383 12 infection infection NN cord-015922-5wwy0m2k 383 13 and and CC cord-015922-5wwy0m2k 383 14 community community NN cord-015922-5wwy0m2k 383 15 - - HYPH cord-015922-5wwy0m2k 383 16 acquired acquire VBN cord-015922-5wwy0m2k 383 17 respiratory respiratory JJ cord-015922-5wwy0m2k 383 18 virus virus NN cord-015922-5wwy0m2k 383 19 infection infection NN cord-015922-5wwy0m2k 383 20 threaten threaten VBP cord-015922-5wwy0m2k 383 21 the the DT cord-015922-5wwy0m2k 383 22 well well RB cord-015922-5wwy0m2k 383 23 - - HYPH cord-015922-5wwy0m2k 383 24 being being NN cord-015922-5wwy0m2k 383 25 of of IN cord-015922-5wwy0m2k 383 26 these these DT cord-015922-5wwy0m2k 383 27 patients patient NNS cord-015922-5wwy0m2k 383 28 . . . cord-015922-5wwy0m2k 384 1 There there EX cord-015922-5wwy0m2k 384 2 are be VBP cord-015922-5wwy0m2k 384 3 two two CD cord-015922-5wwy0m2k 384 4 phases phase NNS cord-015922-5wwy0m2k 384 5 of of IN cord-015922-5wwy0m2k 384 6 the the DT cord-015922-5wwy0m2k 384 7 post post JJ cord-015922-5wwy0m2k 384 8 - - JJ cord-015922-5wwy0m2k 384 9 transplant transplant JJ cord-015922-5wwy0m2k 384 10 course course NN cord-015922-5wwy0m2k 384 11 when when WRB cord-015922-5wwy0m2k 384 12 the the DT cord-015922-5wwy0m2k 384 13 patient patient NN cord-015922-5wwy0m2k 384 14 is be VBZ cord-015922-5wwy0m2k 384 15 at at IN cord-015922-5wwy0m2k 384 16 particular particular JJ cord-015922-5wwy0m2k 384 17 risk risk NN cord-015922-5wwy0m2k 384 18 : : : cord-015922-5wwy0m2k 384 19 preengraftment preengraftment NNP cord-015922-5wwy0m2k 384 20 with with IN cord-015922-5wwy0m2k 384 21 profound profound JJ cord-015922-5wwy0m2k 384 22 granulocytopenia granulocytopenia NNP cord-015922-5wwy0m2k 384 23 and and CC cord-015922-5wwy0m2k 384 24 mucositis mucositis NNP cord-015922-5wwy0m2k 384 25 , , , cord-015922-5wwy0m2k 384 26 and and CC cord-015922-5wwy0m2k 384 27 post post JJ cord-015922-5wwy0m2k 384 28 - - NN cord-015922-5wwy0m2k 384 29 engraftment engraftment JJ cord-015922-5wwy0m2k 384 30 when when WRB cord-015922-5wwy0m2k 384 31 GVHD GVHD NNP cord-015922-5wwy0m2k 384 32 and and CC cord-015922-5wwy0m2k 384 33 its -PRON- PRP$ cord-015922-5wwy0m2k 384 34 therapy therapy NN cord-015922-5wwy0m2k 384 35 render render VBP cord-015922-5wwy0m2k 384 36 the the DT cord-015922-5wwy0m2k 384 37 patient patient NN cord-015922-5wwy0m2k 384 38 vulnerable vulnerable JJ cord-015922-5wwy0m2k 384 39 to to IN cord-015922-5wwy0m2k 384 40 both both CC cord-015922-5wwy0m2k 384 41 fungal fungal JJ cord-015922-5wwy0m2k 384 42 and and CC cord-015922-5wwy0m2k 384 43 viral viral JJ cord-015922-5wwy0m2k 384 44 infection infection NN cord-015922-5wwy0m2k 384 45 . . . cord-015922-5wwy0m2k 385 1 New new JJ cord-015922-5wwy0m2k 385 2 preventative preventative JJ cord-015922-5wwy0m2k 385 3 strategies strategy NNS cord-015922-5wwy0m2k 385 4 are be VBP cord-015922-5wwy0m2k 385 5 being be VBG cord-015922-5wwy0m2k 385 6 formulated formulate VBN cord-015922-5wwy0m2k 385 7 involving involve VBG cord-015922-5wwy0m2k 385 8 both both CC cord-015922-5wwy0m2k 385 9 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 385 10 and and CC cord-015922-5wwy0m2k 385 11 preemptive preemptive JJ cord-015922-5wwy0m2k 385 12 therapy therapy NN cord-015922-5wwy0m2k 385 13 . . . cord-015922-5wwy0m2k 386 1 Similarly similarly RB cord-015922-5wwy0m2k 386 2 , , , cord-015922-5wwy0m2k 386 3 new new JJ cord-015922-5wwy0m2k 386 4 non non JJ cord-015922-5wwy0m2k 386 5 - - JJ cord-015922-5wwy0m2k 386 6 culture culture JJ cord-015922-5wwy0m2k 386 7 diagnostic diagnostic JJ cord-015922-5wwy0m2k 386 8 approaches approach NNS cord-015922-5wwy0m2k 386 9 that that WDT cord-015922-5wwy0m2k 386 10 rely rely VBP cord-015922-5wwy0m2k 386 11 on on IN cord-015922-5wwy0m2k 386 12 antigen antigen NN cord-015922-5wwy0m2k 386 13 detection detection NN cord-015922-5wwy0m2k 386 14 or or CC cord-015922-5wwy0m2k 386 15 PCR PCR NNP cord-015922-5wwy0m2k 386 16 detection detection NN cord-015922-5wwy0m2k 386 17 of of IN cord-015922-5wwy0m2k 386 18 microbial microbial JJ cord-015922-5wwy0m2k 386 19 DNA dna NN cord-015922-5wwy0m2k 386 20 are be VBP cord-015922-5wwy0m2k 386 21 being be VBG cord-015922-5wwy0m2k 386 22 developed develop VBN cord-015922-5wwy0m2k 386 23 . . . cord-015922-5wwy0m2k 387 1 New new JJ cord-015922-5wwy0m2k 387 2 therapies therapy NNS cord-015922-5wwy0m2k 387 3 , , , cord-015922-5wwy0m2k 387 4 both both CC cord-015922-5wwy0m2k 387 5 antiviral antiviral JJ cord-015922-5wwy0m2k 387 6 and and CC cord-015922-5wwy0m2k 387 7 antifungal antifungal JJ cord-015922-5wwy0m2k 387 8 , , , cord-015922-5wwy0m2k 387 9 have have VBP cord-015922-5wwy0m2k 387 10 emerged emerge VBN cord-015922-5wwy0m2k 387 11 . . . cord-015922-5wwy0m2k 388 1 These these DT cord-015922-5wwy0m2k 388 2 should should MD cord-015922-5wwy0m2k 388 3 prompt prompt VB cord-015922-5wwy0m2k 388 4 much much RB cord-015922-5wwy0m2k 388 5 more more RBR cord-015922-5wwy0m2k 388 6 effective effective JJ cord-015922-5wwy0m2k 388 7 prevention prevention NN cord-015922-5wwy0m2k 388 8 and and CC cord-015922-5wwy0m2k 388 9 therapeutic therapeutic JJ cord-015922-5wwy0m2k 388 10 strategies strategy NNS cord-015922-5wwy0m2k 388 11 . . . cord-015922-5wwy0m2k 388 12 _SP cord-015922-5wwy0m2k 389 1 Infection infection NN cord-015922-5wwy0m2k 389 2 in in IN cord-015922-5wwy0m2k 389 3 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 389 4 stem stem NN cord-015922-5wwy0m2k 389 5 cell cell NN cord-015922-5wwy0m2k 389 6 tansplantation tansplantation NN cord-015922-5wwy0m2k 389 7 Quantitative quantitative JJ cord-015922-5wwy0m2k 389 8 relationships relationship NNS cord-015922-5wwy0m2k 389 9 between between IN cord-015922-5wwy0m2k 389 10 circulating circulate VBG cord-015922-5wwy0m2k 389 11 leukocytes leukocyte NNS cord-015922-5wwy0m2k 389 12 and and CC cord-015922-5wwy0m2k 389 13 infection infection NN cord-015922-5wwy0m2k 389 14 in in IN cord-015922-5wwy0m2k 389 15 patients patient NNS cord-015922-5wwy0m2k 389 16 with with IN cord-015922-5wwy0m2k 389 17 acute acute JJ cord-015922-5wwy0m2k 389 18 leukemia leukemia NN cord-015922-5wwy0m2k 389 19 Guidelines guideline NNS cord-015922-5wwy0m2k 389 20 for for IN cord-015922-5wwy0m2k 389 21 preventing prevent VBG cord-015922-5wwy0m2k 389 22 opportunistic opportunistic JJ cord-015922-5wwy0m2k 389 23 infections infection NNS cord-015922-5wwy0m2k 389 24 among among IN cord-015922-5wwy0m2k 389 25 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 389 26 stem stem NN cord-015922-5wwy0m2k 389 27 cell cell NN cord-015922-5wwy0m2k 389 28 transplant transplant NN cord-015922-5wwy0m2k 389 29 recipients recipient NNS cord-015922-5wwy0m2k 389 30 Preventing prevent VBG cord-015922-5wwy0m2k 389 31 opportunistic opportunistic JJ cord-015922-5wwy0m2k 389 32 infections infection NNS cord-015922-5wwy0m2k 389 33 after after IN cord-015922-5wwy0m2k 389 34 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 389 35 stem stem NN cord-015922-5wwy0m2k 389 36 cell cell NN cord-015922-5wwy0m2k 389 37 transplantation transplantation NN cord-015922-5wwy0m2k 389 38 : : : cord-015922-5wwy0m2k 389 39 the the DT cord-015922-5wwy0m2k 389 40 Centers Centers NNPS cord-015922-5wwy0m2k 389 41 for for IN cord-015922-5wwy0m2k 389 42 Disease Disease NNP cord-015922-5wwy0m2k 389 43 Control Control NNP cord-015922-5wwy0m2k 389 44 and and CC cord-015922-5wwy0m2k 389 45 Prevention Prevention NNP cord-015922-5wwy0m2k 389 46 , , , cord-015922-5wwy0m2k 389 47 Infectious Infectious NNP cord-015922-5wwy0m2k 389 48 Diseases Diseases NNPS cord-015922-5wwy0m2k 389 49 Society Society NNP cord-015922-5wwy0m2k 389 50 of of IN cord-015922-5wwy0m2k 389 51 America America NNP cord-015922-5wwy0m2k 389 52 , , , cord-015922-5wwy0m2k 389 53 and and CC cord-015922-5wwy0m2k 389 54 American American NNP cord-015922-5wwy0m2k 389 55 Society Society NNP cord-015922-5wwy0m2k 389 56 for for IN cord-015922-5wwy0m2k 389 57 Blood blood NN cord-015922-5wwy0m2k 389 58 and and CC cord-015922-5wwy0m2k 389 59 Marrow Marrow NNP cord-015922-5wwy0m2k 389 60 Transplantation Transplantation NNP cord-015922-5wwy0m2k 389 61 Practice Practice NNP cord-015922-5wwy0m2k 389 62 Guidelines Guidelines NNPS cord-015922-5wwy0m2k 389 63 and and CC cord-015922-5wwy0m2k 389 64 beyond beyond RB cord-015922-5wwy0m2k 389 65 . . . cord-015922-5wwy0m2k 390 1 Hematology Hematology NNP cord-015922-5wwy0m2k 390 2 / / , cord-015922-5wwy0m2k 390 3 the the DT cord-015922-5wwy0m2k 390 4 Education Education NNP cord-015922-5wwy0m2k 390 5 Program Program NNP cord-015922-5wwy0m2k 390 6 of of IN cord-015922-5wwy0m2k 390 7 the the DT cord-015922-5wwy0m2k 390 8 Invasive invasive JJ cord-015922-5wwy0m2k 390 9 aspergillus aspergillus NN cord-015922-5wwy0m2k 390 10 infection infection NN cord-015922-5wwy0m2k 390 11 : : : cord-015922-5wwy0m2k 390 12 possible possible JJ cord-015922-5wwy0m2k 390 13 nonward nonward NN cord-015922-5wwy0m2k 390 14 common common JJ cord-015922-5wwy0m2k 390 15 source source NN cord-015922-5wwy0m2k 390 16 within within IN cord-015922-5wwy0m2k 390 17 the the DT cord-015922-5wwy0m2k 390 18 hospital hospital NN cord-015922-5wwy0m2k 390 19 environment environment NN cord-015922-5wwy0m2k 390 20 Septicemia septicemia NN cord-015922-5wwy0m2k 390 21 and and CC cord-015922-5wwy0m2k 390 22 shock shock NN cord-015922-5wwy0m2k 390 23 syndrome syndrome NN cord-015922-5wwy0m2k 390 24 due due IN cord-015922-5wwy0m2k 390 25 to to IN cord-015922-5wwy0m2k 390 26 viridans viridans NNP cord-015922-5wwy0m2k 390 27 streptococci streptococcus NNS cord-015922-5wwy0m2k 390 28 : : : cord-015922-5wwy0m2k 390 29 a a DT cord-015922-5wwy0m2k 390 30 case case NN cord-015922-5wwy0m2k 390 31 - - HYPH cord-015922-5wwy0m2k 390 32 control control NN cord-015922-5wwy0m2k 390 33 study study NN cord-015922-5wwy0m2k 390 34 of of IN cord-015922-5wwy0m2k 390 35 predisposing predisposing JJ cord-015922-5wwy0m2k 390 36 factors factor NNS cord-015922-5wwy0m2k 390 37 Introduction introduction NN cord-015922-5wwy0m2k 390 38 to to IN cord-015922-5wwy0m2k 390 39 marrow marrow NN cord-015922-5wwy0m2k 390 40 and and CC cord-015922-5wwy0m2k 390 41 blood blood NN cord-015922-5wwy0m2k 390 42 stem stem NN cord-015922-5wwy0m2k 390 43 cell cell NN cord-015922-5wwy0m2k 390 44 transplantation transplantation NN cord-015922-5wwy0m2k 390 45 Infectious infectious JJ cord-015922-5wwy0m2k 390 46 complications complication NNS cord-015922-5wwy0m2k 390 47 associated associate VBN cord-015922-5wwy0m2k 390 48 with with IN cord-015922-5wwy0m2k 390 49 alemtuzumab alemtuzumab JJ cord-015922-5wwy0m2k 390 50 use use NN cord-015922-5wwy0m2k 390 51 for for IN cord-015922-5wwy0m2k 390 52 lymphoproliferative lymphoproliferative JJ cord-015922-5wwy0m2k 390 53 disorders disorder NNS cord-015922-5wwy0m2k 391 1 Infliximab Infliximab NNP cord-015922-5wwy0m2k 391 2 use use VBP cord-015922-5wwy0m2k 391 3 in in IN cord-015922-5wwy0m2k 391 4 patients patient NNS cord-015922-5wwy0m2k 391 5 with with IN cord-015922-5wwy0m2k 391 6 severe severe JJ cord-015922-5wwy0m2k 391 7 graftversus graftversus NN cord-015922-5wwy0m2k 391 8 - - HYPH cord-015922-5wwy0m2k 391 9 host host NN cord-015922-5wwy0m2k 391 10 disease disease NN cord-015922-5wwy0m2k 391 11 and and CC cord-015922-5wwy0m2k 391 12 other other JJ cord-015922-5wwy0m2k 391 13 emerging emerge VBG cord-015922-5wwy0m2k 391 14 risk risk NN cord-015922-5wwy0m2k 391 15 factors factor NNS cord-015922-5wwy0m2k 391 16 of of IN cord-015922-5wwy0m2k 391 17 non non JJ cord-015922-5wwy0m2k 391 18 - - JJ cord-015922-5wwy0m2k 391 19 Candida candida JJ cord-015922-5wwy0m2k 391 20 invasive invasive JJ cord-015922-5wwy0m2k 391 21 fungal fungal JJ cord-015922-5wwy0m2k 391 22 infections infection NNS cord-015922-5wwy0m2k 391 23 in in IN cord-015922-5wwy0m2k 391 24 allogeneic allogeneic JJ cord-015922-5wwy0m2k 391 25 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 391 26 stem stem NN cord-015922-5wwy0m2k 391 27 cell cell NN cord-015922-5wwy0m2k 391 28 transplant transplant NN cord-015922-5wwy0m2k 391 29 recipients recipient NNS cord-015922-5wwy0m2k 391 30 : : : cord-015922-5wwy0m2k 391 31 a a DT cord-015922-5wwy0m2k 391 32 cohort cohort NN cord-015922-5wwy0m2k 391 33 study study NN cord-015922-5wwy0m2k 391 34 Risks risk NNS cord-015922-5wwy0m2k 391 35 and and CC cord-015922-5wwy0m2k 391 36 outcomes outcome NNS cord-015922-5wwy0m2k 391 37 of of IN cord-015922-5wwy0m2k 391 38 invasive invasive JJ cord-015922-5wwy0m2k 391 39 fungal fungal JJ cord-015922-5wwy0m2k 391 40 infections infection NNS cord-015922-5wwy0m2k 391 41 in in IN cord-015922-5wwy0m2k 391 42 recipients recipient NNS cord-015922-5wwy0m2k 391 43 of of IN cord-015922-5wwy0m2k 391 44 allogeneic allogeneic NN cord-015922-5wwy0m2k 391 45 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 391 46 stem stem NN cord-015922-5wwy0m2k 391 47 cell cell NN cord-015922-5wwy0m2k 391 48 transplants transplant NNS cord-015922-5wwy0m2k 391 49 after after IN cord-015922-5wwy0m2k 391 50 nonmyeloablative nonmyeloablative JJ cord-015922-5wwy0m2k 391 51 conditioning conditioning NN cord-015922-5wwy0m2k 391 52 Invasive invasive JJ cord-015922-5wwy0m2k 391 53 aspergillosis aspergillosis NN cord-015922-5wwy0m2k 391 54 following follow VBG cord-015922-5wwy0m2k 391 55 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 391 56 cell cell NN cord-015922-5wwy0m2k 391 57 transplantation transplantation NN cord-015922-5wwy0m2k 391 58 : : : cord-015922-5wwy0m2k 391 59 outcomes outcome NNS cord-015922-5wwy0m2k 391 60 and and CC cord-015922-5wwy0m2k 391 61 prognostic prognostic JJ cord-015922-5wwy0m2k 391 62 factors factor NNS cord-015922-5wwy0m2k 391 63 associated associate VBN cord-015922-5wwy0m2k 391 64 with with IN cord-015922-5wwy0m2k 391 65 mortality mortality NN cord-015922-5wwy0m2k 391 66 Galactomannan Galactomannan NNP cord-015922-5wwy0m2k 391 67 and and CC cord-015922-5wwy0m2k 391 68 computed compute VBD cord-015922-5wwy0m2k 391 69 tomography tomography NN cord-015922-5wwy0m2k 391 70 - - HYPH cord-015922-5wwy0m2k 391 71 based base VBN cord-015922-5wwy0m2k 391 72 preemptive preemptive JJ cord-015922-5wwy0m2k 391 73 antifungal antifungal JJ cord-015922-5wwy0m2k 391 74 therapy therapy NN cord-015922-5wwy0m2k 391 75 in in IN cord-015922-5wwy0m2k 391 76 neutropenic neutropenic JJ cord-015922-5wwy0m2k 391 77 patients patient NNS cord-015922-5wwy0m2k 391 78 at at IN cord-015922-5wwy0m2k 391 79 high high JJ cord-015922-5wwy0m2k 391 80 risk risk NN cord-015922-5wwy0m2k 391 81 for for IN cord-015922-5wwy0m2k 391 82 invasive invasive JJ cord-015922-5wwy0m2k 391 83 fungal fungal JJ cord-015922-5wwy0m2k 391 84 infection infection NN cord-015922-5wwy0m2k 391 85 : : : cord-015922-5wwy0m2k 392 1 a a DT cord-015922-5wwy0m2k 392 2 prospective prospective JJ cord-015922-5wwy0m2k 392 3 feasibility feasibility NN cord-015922-5wwy0m2k 392 4 study study NN cord-015922-5wwy0m2k 392 5 Levofloxacin Levofloxacin NNP cord-015922-5wwy0m2k 392 6 to to TO cord-015922-5wwy0m2k 392 7 prevent prevent VB cord-015922-5wwy0m2k 392 8 bacterial bacterial JJ cord-015922-5wwy0m2k 392 9 infection infection NN cord-015922-5wwy0m2k 392 10 in in IN cord-015922-5wwy0m2k 392 11 patients patient NNS cord-015922-5wwy0m2k 392 12 with with IN cord-015922-5wwy0m2k 392 13 cancer cancer NN cord-015922-5wwy0m2k 392 14 and and CC cord-015922-5wwy0m2k 392 15 neutropenia neutropenia NN cord-015922-5wwy0m2k 392 16 Antibacterial antibacterial JJ cord-015922-5wwy0m2k 392 17 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 392 18 after after IN cord-015922-5wwy0m2k 392 19 chemotherapy chemotherapy NN cord-015922-5wwy0m2k 392 20 for for IN cord-015922-5wwy0m2k 392 21 solid solid JJ cord-015922-5wwy0m2k 392 22 tumors tumor NNS cord-015922-5wwy0m2k 392 23 and and CC cord-015922-5wwy0m2k 392 24 lymphomas lymphoma NNS cord-015922-5wwy0m2k 392 25 Prophylactic prophylactic JJ cord-015922-5wwy0m2k 392 26 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 392 27 agents agent NNS cord-015922-5wwy0m2k 392 28 and and CC cord-015922-5wwy0m2k 392 29 the the DT cord-015922-5wwy0m2k 392 30 importance importance NN cord-015922-5wwy0m2k 392 31 of of IN cord-015922-5wwy0m2k 392 32 fitness fitness NN cord-015922-5wwy0m2k 392 33 Changing change VBG cord-015922-5wwy0m2k 392 34 epidemiology epidemiology NN cord-015922-5wwy0m2k 392 35 of of IN cord-015922-5wwy0m2k 392 36 infections infection NNS cord-015922-5wwy0m2k 392 37 in in IN cord-015922-5wwy0m2k 392 38 patients patient NNS cord-015922-5wwy0m2k 392 39 with with IN cord-015922-5wwy0m2k 392 40 neutropenia neutropenia NN cord-015922-5wwy0m2k 392 41 and and CC cord-015922-5wwy0m2k 392 42 cancer cancer NN cord-015922-5wwy0m2k 392 43 : : : cord-015922-5wwy0m2k 392 44 emphasis emphasis NN cord-015922-5wwy0m2k 392 45 on on IN cord-015922-5wwy0m2k 392 46 gram gram NN cord-015922-5wwy0m2k 392 47 - - HYPH cord-015922-5wwy0m2k 392 48 positive positive JJ cord-015922-5wwy0m2k 392 49 and and CC cord-015922-5wwy0m2k 392 50 resistant resistant JJ cord-015922-5wwy0m2k 392 51 bacteria bacteria NNS cord-015922-5wwy0m2k 392 52 Outcomes outcome NNS cord-015922-5wwy0m2k 392 53 of of IN cord-015922-5wwy0m2k 392 54 bacteremia bacteremia NN cord-015922-5wwy0m2k 392 55 in in IN cord-015922-5wwy0m2k 392 56 patients patient NNS cord-015922-5wwy0m2k 392 57 with with IN cord-015922-5wwy0m2k 392 58 cancer cancer NN cord-015922-5wwy0m2k 392 59 and and CC cord-015922-5wwy0m2k 392 60 neutropenia neutropenia NN cord-015922-5wwy0m2k 392 61 : : : cord-015922-5wwy0m2k 392 62 observations observation NNS cord-015922-5wwy0m2k 392 63 from from IN cord-015922-5wwy0m2k 392 64 two two CD cord-015922-5wwy0m2k 392 65 decades decade NNS cord-015922-5wwy0m2k 392 66 of of IN cord-015922-5wwy0m2k 392 67 epidemiological epidemiological JJ cord-015922-5wwy0m2k 392 68 and and CC cord-015922-5wwy0m2k 392 69 clinical clinical JJ cord-015922-5wwy0m2k 392 70 trials trial NNS cord-015922-5wwy0m2k 392 71 Escherichia Escherichia NNP cord-015922-5wwy0m2k 392 72 coli coli NNS cord-015922-5wwy0m2k 392 73 resistant resistant JJ cord-015922-5wwy0m2k 392 74 to to IN cord-015922-5wwy0m2k 392 75 fluoroquinolones fluoroquinolone NNS cord-015922-5wwy0m2k 392 76 in in IN cord-015922-5wwy0m2k 392 77 patients patient NNS cord-015922-5wwy0m2k 392 78 with with IN cord-015922-5wwy0m2k 392 79 cancer cancer NN cord-015922-5wwy0m2k 392 80 and and CC cord-015922-5wwy0m2k 392 81 neutropenia neutropenia NN cord-015922-5wwy0m2k 392 82 Ceftazidime Ceftazidime NNP cord-015922-5wwy0m2k 392 83 combined combine VBD cord-015922-5wwy0m2k 392 84 with with IN cord-015922-5wwy0m2k 392 85 a a DT cord-015922-5wwy0m2k 392 86 short short JJ cord-015922-5wwy0m2k 392 87 or or CC cord-015922-5wwy0m2k 392 88 long long JJ cord-015922-5wwy0m2k 392 89 course course NN cord-015922-5wwy0m2k 392 90 of of IN cord-015922-5wwy0m2k 392 91 amikacin amikacin NN cord-015922-5wwy0m2k 392 92 for for IN cord-015922-5wwy0m2k 392 93 empirical empirical JJ cord-015922-5wwy0m2k 392 94 therapy therapy NN cord-015922-5wwy0m2k 392 95 of of IN cord-015922-5wwy0m2k 392 96 gram gram JJ cord-015922-5wwy0m2k 392 97 - - HYPH cord-015922-5wwy0m2k 392 98 negative negative JJ cord-015922-5wwy0m2k 392 99 bacteremia bacteremia NN cord-015922-5wwy0m2k 392 100 in in IN cord-015922-5wwy0m2k 392 101 cancer cancer NN cord-015922-5wwy0m2k 392 102 patients patient NNS cord-015922-5wwy0m2k 392 103 with with IN cord-015922-5wwy0m2k 392 104 granulocytopenia granulocytopenia NNP cord-015922-5wwy0m2k 392 105 . . . cord-015922-5wwy0m2k 393 1 The the DT cord-015922-5wwy0m2k 393 2 EORTC EORTC NNP cord-015922-5wwy0m2k 393 3 International International NNP cord-015922-5wwy0m2k 393 4 Antimicrobial Antimicrobial NNP cord-015922-5wwy0m2k 393 5 Therapy Therapy NNP cord-015922-5wwy0m2k 393 6 Cooperative Cooperative NNP cord-015922-5wwy0m2k 393 7 Group Group NNP cord-015922-5wwy0m2k 393 8 Gram Gram NNP cord-015922-5wwy0m2k 393 9 - - HYPH cord-015922-5wwy0m2k 393 10 positive positive JJ cord-015922-5wwy0m2k 393 11 infections infection NNS cord-015922-5wwy0m2k 393 12 and and CC cord-015922-5wwy0m2k 393 13 the the DT cord-015922-5wwy0m2k 393 14 use use NN cord-015922-5wwy0m2k 393 15 of of IN cord-015922-5wwy0m2k 393 16 vancomycin vancomycin NN cord-015922-5wwy0m2k 393 17 in in IN cord-015922-5wwy0m2k 393 18 550 550 CD cord-015922-5wwy0m2k 393 19 episodes episode NNS cord-015922-5wwy0m2k 393 20 of of IN cord-015922-5wwy0m2k 393 21 fever fever NN cord-015922-5wwy0m2k 393 22 and and CC cord-015922-5wwy0m2k 393 23 neutropenia neutropenia NN cord-015922-5wwy0m2k 393 24 guidelines guideline NNS cord-015922-5wwy0m2k 393 25 for for IN cord-015922-5wwy0m2k 393 26 the the DT cord-015922-5wwy0m2k 393 27 use use NN cord-015922-5wwy0m2k 393 28 of of IN cord-015922-5wwy0m2k 393 29 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 393 30 agents agent NNS cord-015922-5wwy0m2k 393 31 in in IN cord-015922-5wwy0m2k 393 32 neutropenic neutropenic JJ cord-015922-5wwy0m2k 393 33 patients patient NNS cord-015922-5wwy0m2k 393 34 with with IN cord-015922-5wwy0m2k 393 35 cancer cancer NN cord-015922-5wwy0m2k 393 36 Duration duration NN cord-015922-5wwy0m2k 393 37 of of IN cord-015922-5wwy0m2k 393 38 empiric empiric JJ cord-015922-5wwy0m2k 393 39 antibiotic antibiotic JJ cord-015922-5wwy0m2k 393 40 therapy therapy NN cord-015922-5wwy0m2k 393 41 in in IN cord-015922-5wwy0m2k 393 42 granulocytopenic granulocytopenic NN cord-015922-5wwy0m2k 393 43 patients patient NNS cord-015922-5wwy0m2k 393 44 with with IN cord-015922-5wwy0m2k 393 45 cancer cancer NN cord-015922-5wwy0m2k 393 46 Guidelines guideline NNS cord-015922-5wwy0m2k 393 47 for for IN cord-015922-5wwy0m2k 393 48 the the DT cord-015922-5wwy0m2k 393 49 prevention prevention NN cord-015922-5wwy0m2k 393 50 of of IN cord-015922-5wwy0m2k 393 51 intravascular intravascular JJ cord-015922-5wwy0m2k 393 52 catheter catheter NN cord-015922-5wwy0m2k 393 53 - - HYPH cord-015922-5wwy0m2k 393 54 related relate VBN cord-015922-5wwy0m2k 393 55 infections infection NNS cord-015922-5wwy0m2k 393 56 . . . cord-015922-5wwy0m2k 394 1 The the DT cord-015922-5wwy0m2k 394 2 Hospital Hospital NNP cord-015922-5wwy0m2k 394 3 Infection Infection NNP cord-015922-5wwy0m2k 394 4 Control Control NNP cord-015922-5wwy0m2k 394 5 Practices Practices NNPS cord-015922-5wwy0m2k 394 6 Advisory Advisory NNP cord-015922-5wwy0m2k 394 7 Committee Committee NNP cord-015922-5wwy0m2k 394 8 Palifermin Palifermin NNP cord-015922-5wwy0m2k 394 9 for for IN cord-015922-5wwy0m2k 394 10 oral oral JJ cord-015922-5wwy0m2k 394 11 mucositis mucositis NN cord-015922-5wwy0m2k 394 12 after after IN cord-015922-5wwy0m2k 394 13 intensive intensive JJ cord-015922-5wwy0m2k 394 14 therapy therapy NN cord-015922-5wwy0m2k 394 15 for for IN cord-015922-5wwy0m2k 394 16 hematologic hematologic JJ cord-015922-5wwy0m2k 394 17 cancers cancer NNS cord-015922-5wwy0m2k 395 1 The the DT cord-015922-5wwy0m2k 395 2 use use NN cord-015922-5wwy0m2k 395 3 of of IN cord-015922-5wwy0m2k 395 4 intravenous intravenous JJ cord-015922-5wwy0m2k 395 5 immune immune JJ cord-015922-5wwy0m2k 395 6 globulin globulin NN cord-015922-5wwy0m2k 395 7 in in IN cord-015922-5wwy0m2k 395 8 immunodeficiency immunodeficiency NN cord-015922-5wwy0m2k 395 9 diseases disease NNS cord-015922-5wwy0m2k 396 1 A a DT cord-015922-5wwy0m2k 396 2 controlled control VBN cord-015922-5wwy0m2k 396 3 trial trial NN cord-015922-5wwy0m2k 396 4 of of IN cord-015922-5wwy0m2k 396 5 long long JJ cord-015922-5wwy0m2k 396 6 - - HYPH cord-015922-5wwy0m2k 396 7 term term NN cord-015922-5wwy0m2k 396 8 administration administration NN cord-015922-5wwy0m2k 396 9 of of IN cord-015922-5wwy0m2k 396 10 intravenous intravenous JJ cord-015922-5wwy0m2k 396 11 immunoglobulin immunoglobulin NN cord-015922-5wwy0m2k 396 12 to to TO cord-015922-5wwy0m2k 396 13 prevent prevent VB cord-015922-5wwy0m2k 396 14 late late JJ cord-015922-5wwy0m2k 396 15 infection infection NN cord-015922-5wwy0m2k 396 16 and and CC cord-015922-5wwy0m2k 396 17 chronic chronic JJ cord-015922-5wwy0m2k 396 18 graft graft NN cord-015922-5wwy0m2k 396 19 - - HYPH cord-015922-5wwy0m2k 396 20 vs.-host vs.-host NN cord-015922-5wwy0m2k 396 21 disease disease NN cord-015922-5wwy0m2k 396 22 after after IN cord-015922-5wwy0m2k 396 23 marrow marrow NN cord-015922-5wwy0m2k 396 24 transplantation transplantation NN cord-015922-5wwy0m2k 396 25 : : : cord-015922-5wwy0m2k 396 26 clinical clinical JJ cord-015922-5wwy0m2k 396 27 outcome outcome NN cord-015922-5wwy0m2k 396 28 and and CC cord-015922-5wwy0m2k 396 29 effect effect NN cord-015922-5wwy0m2k 396 30 on on IN cord-015922-5wwy0m2k 396 31 subsequent subsequent JJ cord-015922-5wwy0m2k 396 32 immune immune JJ cord-015922-5wwy0m2k 396 33 recovery recovery NN cord-015922-5wwy0m2k 397 1 The the DT cord-015922-5wwy0m2k 397 2 therapeutic therapeutic JJ cord-015922-5wwy0m2k 397 3 prescription prescription NN cord-015922-5wwy0m2k 397 4 for for IN cord-015922-5wwy0m2k 397 5 the the DT cord-015922-5wwy0m2k 397 6 organ organ NN cord-015922-5wwy0m2k 397 7 transplant transplant NN cord-015922-5wwy0m2k 397 8 recipient recipient NN cord-015922-5wwy0m2k 397 9 : : : cord-015922-5wwy0m2k 397 10 the the DT cord-015922-5wwy0m2k 397 11 linkage linkage NN cord-015922-5wwy0m2k 397 12 of of IN cord-015922-5wwy0m2k 397 13 immunosuppression immunosuppression NN cord-015922-5wwy0m2k 397 14 and and CC cord-015922-5wwy0m2k 397 15 antimicrobial antimicrobial JJ cord-015922-5wwy0m2k 397 16 strategies strategy NNS cord-015922-5wwy0m2k 397 17 Cytomegalovirus Cytomegalovirus NNP cord-015922-5wwy0m2k 397 18 in in IN cord-015922-5wwy0m2k 397 19 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 397 20 stem stem NN cord-015922-5wwy0m2k 397 21 cell cell NN cord-015922-5wwy0m2k 397 22 transplant transplant NN cord-015922-5wwy0m2k 397 23 recipients recipient NNS cord-015922-5wwy0m2k 397 24 : : : cord-015922-5wwy0m2k 397 25 Current current JJ cord-015922-5wwy0m2k 397 26 status status NN cord-015922-5wwy0m2k 397 27 , , , cord-015922-5wwy0m2k 397 28 known know VBN cord-015922-5wwy0m2k 397 29 challenges challenge NNS cord-015922-5wwy0m2k 397 30 , , , cord-015922-5wwy0m2k 397 31 and and CC cord-015922-5wwy0m2k 397 32 future future JJ cord-015922-5wwy0m2k 397 33 strategies strategy NNS cord-015922-5wwy0m2k 397 34 Sirolimus Sirolimus NNP cord-015922-5wwy0m2k 397 35 - - HYPH cord-015922-5wwy0m2k 397 36 based base VBN cord-015922-5wwy0m2k 397 37 graft graft NN cord-015922-5wwy0m2k 397 38 - - HYPH cord-015922-5wwy0m2k 397 39 versus versus IN cord-015922-5wwy0m2k 397 40 - - HYPH cord-015922-5wwy0m2k 397 41 host host NN cord-015922-5wwy0m2k 397 42 disease disease NN cord-015922-5wwy0m2k 397 43 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 397 44 protects protect VBZ cord-015922-5wwy0m2k 397 45 against against IN cord-015922-5wwy0m2k 397 46 cytomegalovirus cytomegalovirus JJ cord-015922-5wwy0m2k 397 47 reactivation reactivation NN cord-015922-5wwy0m2k 397 48 after after IN cord-015922-5wwy0m2k 397 49 allogeneic allogeneic NN cord-015922-5wwy0m2k 397 50 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 397 51 stem stem NN cord-015922-5wwy0m2k 397 52 cell cell NN cord-015922-5wwy0m2k 397 53 transplantation transplantation NN cord-015922-5wwy0m2k 397 54 : : : cord-015922-5wwy0m2k 397 55 a a DT cord-015922-5wwy0m2k 397 56 cohort cohort NN cord-015922-5wwy0m2k 397 57 analysis analysis NN cord-015922-5wwy0m2k 397 58 Risk risk NN cord-015922-5wwy0m2k 397 59 factors factor NNS cord-015922-5wwy0m2k 397 60 for for IN cord-015922-5wwy0m2k 397 61 cytomegalovirus cytomegalovirus JJ cord-015922-5wwy0m2k 397 62 infection infection NN cord-015922-5wwy0m2k 397 63 after after IN cord-015922-5wwy0m2k 397 64 human human JJ cord-015922-5wwy0m2k 397 65 marrow marrow NN cord-015922-5wwy0m2k 397 66 transplantation transplantation NN cord-015922-5wwy0m2k 397 67 Transfusion Transfusion NNP cord-015922-5wwy0m2k 397 68 - - HYPH cord-015922-5wwy0m2k 397 69 transmitted transmit VBN cord-015922-5wwy0m2k 397 70 cytomegalovirus cytomegalovirus JJ cord-015922-5wwy0m2k 397 71 infection infection NN cord-015922-5wwy0m2k 397 72 after after IN cord-015922-5wwy0m2k 397 73 receipt receipt NN cord-015922-5wwy0m2k 397 74 of of IN cord-015922-5wwy0m2k 397 75 leukoreduced leukoreduced JJ cord-015922-5wwy0m2k 397 76 blood blood NN cord-015922-5wwy0m2k 397 77 products product NNS cord-015922-5wwy0m2k 397 78 Incidence incidence NN cord-015922-5wwy0m2k 397 79 and and CC cord-015922-5wwy0m2k 397 80 outcome outcome NN cord-015922-5wwy0m2k 397 81 of of IN cord-015922-5wwy0m2k 397 82 bacterial bacterial JJ cord-015922-5wwy0m2k 397 83 and and CC cord-015922-5wwy0m2k 397 84 fungal fungal JJ cord-015922-5wwy0m2k 397 85 infections infection NNS cord-015922-5wwy0m2k 397 86 following follow VBG cord-015922-5wwy0m2k 397 87 nonmyeloablative nonmyeloablative NNP cord-015922-5wwy0m2k 397 88 compared compare VBN cord-015922-5wwy0m2k 397 89 with with IN cord-015922-5wwy0m2k 397 90 myeloablative myeloablative JJ cord-015922-5wwy0m2k 397 91 allogeneic allogeneic JJ cord-015922-5wwy0m2k 397 92 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 397 93 stem stem NN cord-015922-5wwy0m2k 397 94 cell cell NN cord-015922-5wwy0m2k 397 95 transplantation transplantation NN cord-015922-5wwy0m2k 397 96 : : : cord-015922-5wwy0m2k 397 97 a a DT cord-015922-5wwy0m2k 397 98 matched match VBN cord-015922-5wwy0m2k 397 99 control control NN cord-015922-5wwy0m2k 397 100 study study NN cord-015922-5wwy0m2k 397 101 Pharmacokinetics Pharmacokinetics NNP cord-015922-5wwy0m2k 397 102 of of IN cord-015922-5wwy0m2k 397 103 ganciclovir ganciclovir NNP cord-015922-5wwy0m2k 397 104 after after IN cord-015922-5wwy0m2k 397 105 oral oral JJ cord-015922-5wwy0m2k 397 106 valganciclovir valganciclovir NNP cord-015922-5wwy0m2k 397 107 versus versus IN cord-015922-5wwy0m2k 397 108 intravenous intravenous JJ cord-015922-5wwy0m2k 397 109 ganciclovir ganciclovir NNS cord-015922-5wwy0m2k 397 110 in in IN cord-015922-5wwy0m2k 397 111 allogeneic allogeneic NN cord-015922-5wwy0m2k 397 112 stem stem NN cord-015922-5wwy0m2k 397 113 cell cell NN cord-015922-5wwy0m2k 397 114 transplant transplant NN cord-015922-5wwy0m2k 397 115 patients patient NNS cord-015922-5wwy0m2k 397 116 with with IN cord-015922-5wwy0m2k 397 117 graft graft NN cord-015922-5wwy0m2k 397 118 - - HYPH cord-015922-5wwy0m2k 397 119 versus versus IN cord-015922-5wwy0m2k 397 120 - - HYPH cord-015922-5wwy0m2k 397 121 host host NN cord-015922-5wwy0m2k 397 122 disease disease NN cord-015922-5wwy0m2k 397 123 of of IN cord-015922-5wwy0m2k 397 124 the the DT cord-015922-5wwy0m2k 397 125 gastrointestinal gastrointestinal JJ cord-015922-5wwy0m2k 397 126 tract tract NN cord-015922-5wwy0m2k 397 127 Oral oral JJ cord-015922-5wwy0m2k 397 128 valganciclovir valganciclovir NNS cord-015922-5wwy0m2k 397 129 leads lead VBZ cord-015922-5wwy0m2k 397 130 to to IN cord-015922-5wwy0m2k 397 131 higher high JJR cord-015922-5wwy0m2k 397 132 exposure exposure NN cord-015922-5wwy0m2k 397 133 to to IN cord-015922-5wwy0m2k 397 134 ganciclovir ganciclovir NNS cord-015922-5wwy0m2k 397 135 than than IN cord-015922-5wwy0m2k 397 136 intravenous intravenous JJ cord-015922-5wwy0m2k 397 137 ganciclovir ganciclovir NNS cord-015922-5wwy0m2k 397 138 in in IN cord-015922-5wwy0m2k 397 139 patients patient NNS cord-015922-5wwy0m2k 397 140 following follow VBG cord-015922-5wwy0m2k 397 141 allogeneic allogeneic IN cord-015922-5wwy0m2k 397 142 stem stem NN cord-015922-5wwy0m2k 397 143 cell cell NN cord-015922-5wwy0m2k 397 144 transplantation transplantation NN cord-015922-5wwy0m2k 397 145 Early early JJ cord-015922-5wwy0m2k 397 146 treatment treatment NN cord-015922-5wwy0m2k 397 147 with with IN cord-015922-5wwy0m2k 397 148 ganciclovir ganciclovir NNS cord-015922-5wwy0m2k 397 149 to to TO cord-015922-5wwy0m2k 397 150 prevent prevent VB cord-015922-5wwy0m2k 397 151 cytomegalovirus cytomegalovirus NN cord-015922-5wwy0m2k 397 152 disease disease NN cord-015922-5wwy0m2k 397 153 after after IN cord-015922-5wwy0m2k 397 154 allogeneic allogeneic NN cord-015922-5wwy0m2k 397 155 bone bone NN cord-015922-5wwy0m2k 397 156 marrow marrow NN cord-015922-5wwy0m2k 397 157 transplantation transplantation NN cord-015922-5wwy0m2k 397 158 Ganciclovir Ganciclovir NNP cord-015922-5wwy0m2k 397 159 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 397 160 to to TO cord-015922-5wwy0m2k 397 161 prevent prevent VB cord-015922-5wwy0m2k 397 162 cytomegalovirus cytomegalovirus NN cord-015922-5wwy0m2k 397 163 disease disease NN cord-015922-5wwy0m2k 397 164 after after IN cord-015922-5wwy0m2k 397 165 allogeneic allogeneic NN cord-015922-5wwy0m2k 397 166 marrow marrow NN cord-015922-5wwy0m2k 397 167 transplant transplant NN cord-015922-5wwy0m2k 397 168 Cytomegalovirus Cytomegalovirus NNP cord-015922-5wwy0m2k 397 169 pp65 pp65 NNP cord-015922-5wwy0m2k 397 170 antigenemia antigenemia NNP cord-015922-5wwy0m2k 397 171 - - HYPH cord-015922-5wwy0m2k 397 172 guided guide VBN cord-015922-5wwy0m2k 397 173 early early JJ cord-015922-5wwy0m2k 397 174 treatment treatment NN cord-015922-5wwy0m2k 397 175 with with IN cord-015922-5wwy0m2k 397 176 ganciclovir ganciclovir NNP cord-015922-5wwy0m2k 397 177 versus versus IN cord-015922-5wwy0m2k 397 178 ganciclovir ganciclovir NNP cord-015922-5wwy0m2k 397 179 at at IN cord-015922-5wwy0m2k 397 180 engraftment engraftment NN cord-015922-5wwy0m2k 397 181 after after IN cord-015922-5wwy0m2k 397 182 allogeneic allogeneic NN cord-015922-5wwy0m2k 397 183 marrow marrow NN cord-015922-5wwy0m2k 397 184 transplantation transplantation NN cord-015922-5wwy0m2k 397 185 : : : cord-015922-5wwy0m2k 397 186 a a DT cord-015922-5wwy0m2k 397 187 randomized randomized JJ cord-015922-5wwy0m2k 397 188 double double JJ cord-015922-5wwy0m2k 397 189 - - HYPH cord-015922-5wwy0m2k 397 190 blind blind JJ cord-015922-5wwy0m2k 397 191 study study NN cord-015922-5wwy0m2k 397 192 Polymerase Polymerase NNP cord-015922-5wwy0m2k 397 193 chain chain NN cord-015922-5wwy0m2k 397 194 reaction reaction NN cord-015922-5wwy0m2k 397 195 monitoring monitoring NN cord-015922-5wwy0m2k 397 196 reduces reduce VBZ cord-015922-5wwy0m2k 397 197 the the DT cord-015922-5wwy0m2k 397 198 incidence incidence NN cord-015922-5wwy0m2k 397 199 of of IN cord-015922-5wwy0m2k 397 200 cytomegalovirus cytomegalovirus JJ cord-015922-5wwy0m2k 397 201 disease disease NN cord-015922-5wwy0m2k 397 202 and and CC cord-015922-5wwy0m2k 397 203 the the DT cord-015922-5wwy0m2k 397 204 duration duration NN cord-015922-5wwy0m2k 397 205 and and CC cord-015922-5wwy0m2k 397 206 side side NN cord-015922-5wwy0m2k 397 207 effects effect NNS cord-015922-5wwy0m2k 397 208 of of IN cord-015922-5wwy0m2k 397 209 antiviral antiviral JJ cord-015922-5wwy0m2k 397 210 therapy therapy NN cord-015922-5wwy0m2k 397 211 after after IN cord-015922-5wwy0m2k 397 212 bone bone NN cord-015922-5wwy0m2k 397 213 marrow marrow NN cord-015922-5wwy0m2k 397 214 transplantation transplantation NN cord-015922-5wwy0m2k 397 215 Successful successful JJ cord-015922-5wwy0m2k 397 216 modification modification NN cord-015922-5wwy0m2k 397 217 of of IN cord-015922-5wwy0m2k 397 218 a a DT cord-015922-5wwy0m2k 397 219 pp65 pp65 NNP cord-015922-5wwy0m2k 397 220 antigenemia antigenemia NNP cord-015922-5wwy0m2k 397 221 - - HYPH cord-015922-5wwy0m2k 397 222 based base VBN cord-015922-5wwy0m2k 397 223 early early JJ cord-015922-5wwy0m2k 397 224 treatment treatment NN cord-015922-5wwy0m2k 397 225 strategy strategy NN cord-015922-5wwy0m2k 397 226 for for IN cord-015922-5wwy0m2k 397 227 prevention prevention NN cord-015922-5wwy0m2k 397 228 of of IN cord-015922-5wwy0m2k 397 229 cytomegalovirus cytomegalovirus JJ cord-015922-5wwy0m2k 397 230 disease disease NN cord-015922-5wwy0m2k 397 231 in in IN cord-015922-5wwy0m2k 397 232 allogeneic allogeneic NN cord-015922-5wwy0m2k 397 233 marrow marrow NN cord-015922-5wwy0m2k 397 234 transplant transplant NN cord-015922-5wwy0m2k 397 235 recipients recipient NNS cord-015922-5wwy0m2k 397 236 Risk risk NN cord-015922-5wwy0m2k 397 237 factors factor NNS cord-015922-5wwy0m2k 397 238 for for IN cord-015922-5wwy0m2k 397 239 treatment treatment NN cord-015922-5wwy0m2k 397 240 failures failure NNS cord-015922-5wwy0m2k 397 241 in in IN cord-015922-5wwy0m2k 397 242 patients patient NNS cord-015922-5wwy0m2k 397 243 receiving receive VBG cord-015922-5wwy0m2k 397 244 PCR PCR NNP cord-015922-5wwy0m2k 397 245 - - HYPH cord-015922-5wwy0m2k 397 246 based base VBN cord-015922-5wwy0m2k 397 247 preemptive preemptive JJ cord-015922-5wwy0m2k 397 248 therapy therapy NN cord-015922-5wwy0m2k 397 249 for for IN cord-015922-5wwy0m2k 397 250 CMV CMV NNP cord-015922-5wwy0m2k 397 251 infection infection NN cord-015922-5wwy0m2k 398 1 Preemptive preemptive JJ cord-015922-5wwy0m2k 398 2 therapy therapy NN cord-015922-5wwy0m2k 398 3 in in IN cord-015922-5wwy0m2k 398 4 immunocompromised immunocompromised JJ cord-015922-5wwy0m2k 398 5 hosts host NNS cord-015922-5wwy0m2k 398 6 Epstein Epstein NNP cord-015922-5wwy0m2k 398 7 - - HYPH cord-015922-5wwy0m2k 398 8 Barr Barr NNP cord-015922-5wwy0m2k 398 9 virus virus NN cord-015922-5wwy0m2k 398 10 and and CC cord-015922-5wwy0m2k 398 11 lymphoproliferatic lymphoproliferatic JJ cord-015922-5wwy0m2k 398 12 disorders disorder NNS cord-015922-5wwy0m2k 398 13 after after IN cord-015922-5wwy0m2k 398 14 transplantation transplantation NN cord-015922-5wwy0m2k 399 1 CD20 CD20 NNP cord-015922-5wwy0m2k 399 2 monoclonal monoclonal JJ cord-015922-5wwy0m2k 399 3 antibody antibody NN cord-015922-5wwy0m2k 399 4 ( ( -LRB- cord-015922-5wwy0m2k 399 5 rituximab rituximab NN cord-015922-5wwy0m2k 399 6 ) ) -RRB- cord-015922-5wwy0m2k 399 7 for for IN cord-015922-5wwy0m2k 399 8 therapy therapy NN cord-015922-5wwy0m2k 399 9 of of IN cord-015922-5wwy0m2k 399 10 Epstein Epstein NNP cord-015922-5wwy0m2k 399 11 - - HYPH cord-015922-5wwy0m2k 399 12 Barr Barr NNP cord-015922-5wwy0m2k 399 13 virus virus NN cord-015922-5wwy0m2k 399 14 lymphoma lymphoma NN cord-015922-5wwy0m2k 399 15 after after IN cord-015922-5wwy0m2k 399 16 hemopoietic hemopoietic JJ cord-015922-5wwy0m2k 399 17 stem stem NN cord-015922-5wwy0m2k 399 18 - - HYPH cord-015922-5wwy0m2k 399 19 cell cell NN cord-015922-5wwy0m2k 399 20 transplantation transplantation NN cord-015922-5wwy0m2k 399 21 Anti anti NN cord-015922-5wwy0m2k 399 22 - - NNP cord-015922-5wwy0m2k 399 23 B b NN cord-015922-5wwy0m2k 399 24 - - HYPH cord-015922-5wwy0m2k 399 25 cell cell NN cord-015922-5wwy0m2k 399 26 monoclonal monoclonal JJ cord-015922-5wwy0m2k 399 27 antibodies antibody NNS cord-015922-5wwy0m2k 399 28 in in IN cord-015922-5wwy0m2k 399 29 the the DT cord-015922-5wwy0m2k 399 30 treatment treatment NN cord-015922-5wwy0m2k 399 31 of of IN cord-015922-5wwy0m2k 399 32 severe severe JJ cord-015922-5wwy0m2k 399 33 B b NN cord-015922-5wwy0m2k 399 34 - - HYPH cord-015922-5wwy0m2k 399 35 cell cell NN cord-015922-5wwy0m2k 399 36 lymphoproliferative lymphoproliferative JJ cord-015922-5wwy0m2k 399 37 syndrome syndrome NN cord-015922-5wwy0m2k 399 38 following follow VBG cord-015922-5wwy0m2k 399 39 bone bone NN cord-015922-5wwy0m2k 399 40 marrow marrow NN cord-015922-5wwy0m2k 399 41 and and CC cord-015922-5wwy0m2k 399 42 organ organ NN cord-015922-5wwy0m2k 399 43 transplantation transplantation NN cord-015922-5wwy0m2k 399 44 Oral oral JJ cord-015922-5wwy0m2k 399 45 acyclovir acyclovir NNP cord-015922-5wwy0m2k 399 46 for for IN cord-015922-5wwy0m2k 399 47 the the DT cord-015922-5wwy0m2k 399 48 long long JJ cord-015922-5wwy0m2k 399 49 - - HYPH cord-015922-5wwy0m2k 399 50 term term NN cord-015922-5wwy0m2k 399 51 suppression suppression NN cord-015922-5wwy0m2k 399 52 of of IN cord-015922-5wwy0m2k 399 53 varcella varcella NNP cord-015922-5wwy0m2k 399 54 zoster zoster NNP cord-015922-5wwy0m2k 399 55 virus virus NN cord-015922-5wwy0m2k 399 56 infection infection NN cord-015922-5wwy0m2k 399 57 after after IN cord-015922-5wwy0m2k 399 58 marrow marrow NN cord-015922-5wwy0m2k 399 59 transplantation transplantation NN cord-015922-5wwy0m2k 400 1 The the DT cord-015922-5wwy0m2k 400 2 effectiveness effectiveness NN cord-015922-5wwy0m2k 400 3 of of IN cord-015922-5wwy0m2k 400 4 the the DT cord-015922-5wwy0m2k 400 5 varicella varicella NN cord-015922-5wwy0m2k 400 6 vaccine vaccine NN cord-015922-5wwy0m2k 400 7 in in IN cord-015922-5wwy0m2k 400 8 clinical clinical JJ cord-015922-5wwy0m2k 400 9 practice practice NN cord-015922-5wwy0m2k 401 1 Postexposure postexposure NN cord-015922-5wwy0m2k 401 2 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 401 3 of of IN cord-015922-5wwy0m2k 401 4 varicella varicella NN cord-015922-5wwy0m2k 401 5 in in IN cord-015922-5wwy0m2k 401 6 family family NN cord-015922-5wwy0m2k 401 7 contact contact NN cord-015922-5wwy0m2k 401 8 by by IN cord-015922-5wwy0m2k 401 9 oral oral JJ cord-015922-5wwy0m2k 401 10 acyclovir acyclovir NNP cord-015922-5wwy0m2k 401 11 Varicella Varicella NNP cord-015922-5wwy0m2k 401 12 - - HYPH cord-015922-5wwy0m2k 401 13 zoster zoster NN cord-015922-5wwy0m2k 401 14 virus virus NN cord-015922-5wwy0m2k 401 15 infection infection NN cord-015922-5wwy0m2k 401 16 in in IN cord-015922-5wwy0m2k 401 17 adult adult NN cord-015922-5wwy0m2k 401 18 patients patient NNS cord-015922-5wwy0m2k 401 19 after after IN cord-015922-5wwy0m2k 401 20 unrelated unrelated JJ cord-015922-5wwy0m2k 401 21 cord cord NN cord-015922-5wwy0m2k 401 22 blood blood NN cord-015922-5wwy0m2k 401 23 transplantation transplantation NN cord-015922-5wwy0m2k 401 24 : : : cord-015922-5wwy0m2k 401 25 a a DT cord-015922-5wwy0m2k 401 26 single single JJ cord-015922-5wwy0m2k 401 27 institute institute NN cord-015922-5wwy0m2k 401 28 experience experience NN cord-015922-5wwy0m2k 401 29 in in IN cord-015922-5wwy0m2k 401 30 Japan Japan NNP cord-015922-5wwy0m2k 401 31 Clinical clinical JJ cord-015922-5wwy0m2k 401 32 outcomes outcome NNS cord-015922-5wwy0m2k 401 33 of of IN cord-015922-5wwy0m2k 401 34 human human JJ cord-015922-5wwy0m2k 401 35 herpesvirus herpesvirus NN cord-015922-5wwy0m2k 401 36 6 6 CD cord-015922-5wwy0m2k 401 37 reactivation reactivation NN cord-015922-5wwy0m2k 401 38 after after IN cord-015922-5wwy0m2k 401 39 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 401 40 stem stem NN cord-015922-5wwy0m2k 401 41 cell cell NN cord-015922-5wwy0m2k 401 42 transplantation transplantation NN cord-015922-5wwy0m2k 401 43 A a DT cord-015922-5wwy0m2k 401 44 population population NN cord-015922-5wwy0m2k 401 45 - - HYPH cord-015922-5wwy0m2k 401 46 based base VBN cord-015922-5wwy0m2k 401 47 study study NN cord-015922-5wwy0m2k 401 48 of of IN cord-015922-5wwy0m2k 401 49 primary primary JJ cord-015922-5wwy0m2k 401 50 human human JJ cord-015922-5wwy0m2k 401 51 herpesvirus herpesvirus NN cord-015922-5wwy0m2k 401 52 6 6 CD cord-015922-5wwy0m2k 401 53 infection infection NN cord-015922-5wwy0m2k 401 54 MR MR NNP cord-015922-5wwy0m2k 401 55 imaging imaging NN cord-015922-5wwy0m2k 401 56 of of IN cord-015922-5wwy0m2k 401 57 human human JJ cord-015922-5wwy0m2k 401 58 herpesvirus-6-associated herpesvirus-6-associate VBN cord-015922-5wwy0m2k 401 59 encephalitis encephalitis RB cord-015922-5wwy0m2k 401 60 in in IN cord-015922-5wwy0m2k 401 61 4 4 CD cord-015922-5wwy0m2k 401 62 patients patient NNS cord-015922-5wwy0m2k 401 63 with with IN cord-015922-5wwy0m2k 401 64 anterograde anterograde JJ cord-015922-5wwy0m2k 401 65 amnesia amnesia NN cord-015922-5wwy0m2k 401 66 after after IN cord-015922-5wwy0m2k 401 67 allogeneic allogeneic NN cord-015922-5wwy0m2k 401 68 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 401 69 stem stem NN cord-015922-5wwy0m2k 401 70 - - HYPH cord-015922-5wwy0m2k 401 71 cell cell NN cord-015922-5wwy0m2k 401 72 transplantation transplantation NN cord-015922-5wwy0m2k 401 73 Post post NN cord-015922-5wwy0m2k 401 74 - - JJ cord-015922-5wwy0m2k 401 75 transplant transplant JJ cord-015922-5wwy0m2k 401 76 acute acute JJ cord-015922-5wwy0m2k 401 77 limbic limbic JJ cord-015922-5wwy0m2k 401 78 encephalitis encephalitis RB cord-015922-5wwy0m2k 401 79 : : : cord-015922-5wwy0m2k 401 80 clinical clinical JJ cord-015922-5wwy0m2k 401 81 features feature NNS cord-015922-5wwy0m2k 401 82 and and CC cord-015922-5wwy0m2k 401 83 relationship relationship NN cord-015922-5wwy0m2k 401 84 to to IN cord-015922-5wwy0m2k 401 85 HHV6 HHV6 NNP cord-015922-5wwy0m2k 401 86 Human Human NNP cord-015922-5wwy0m2k 401 87 herpesvirus herpesvirus NN cord-015922-5wwy0m2k 401 88 6 6 CD cord-015922-5wwy0m2k 401 89 variant variant NN cord-015922-5wwy0m2k 401 90 B b NN cord-015922-5wwy0m2k 401 91 infection infection NN cord-015922-5wwy0m2k 401 92 in in IN cord-015922-5wwy0m2k 401 93 adult adult NN cord-015922-5wwy0m2k 401 94 patients patient NNS cord-015922-5wwy0m2k 401 95 after after IN cord-015922-5wwy0m2k 401 96 unrelated unrelated JJ cord-015922-5wwy0m2k 401 97 cord cord NN cord-015922-5wwy0m2k 401 98 blood blood NN cord-015922-5wwy0m2k 401 99 transplantation transplantation NN cord-015922-5wwy0m2k 401 100 Community Community NNP cord-015922-5wwy0m2k 401 101 respiratory respiratory JJ cord-015922-5wwy0m2k 401 102 virus virus NN cord-015922-5wwy0m2k 401 103 infections infection NNS cord-015922-5wwy0m2k 401 104 among among IN cord-015922-5wwy0m2k 401 105 hospitalized hospitalize VBN cord-015922-5wwy0m2k 401 106 adult adult NN cord-015922-5wwy0m2k 401 107 bone bone NN cord-015922-5wwy0m2k 401 108 marrow marrow NN cord-015922-5wwy0m2k 401 109 transplant transplant NN cord-015922-5wwy0m2k 401 110 recipients recipient NNS cord-015922-5wwy0m2k 401 111 Phase Phase NNP cord-015922-5wwy0m2k 401 112 1 1 CD cord-015922-5wwy0m2k 401 113 evaluation evaluation NN cord-015922-5wwy0m2k 401 114 of of IN cord-015922-5wwy0m2k 401 115 the the DT cord-015922-5wwy0m2k 401 116 respiratory respiratory JJ cord-015922-5wwy0m2k 401 117 syncytial syncytial JJ cord-015922-5wwy0m2k 401 118 virus virus NN cord-015922-5wwy0m2k 401 119 - - HYPH cord-015922-5wwy0m2k 401 120 specific specific JJ cord-015922-5wwy0m2k 401 121 monoclonal monoclonal JJ cord-015922-5wwy0m2k 401 122 antibody antibody NN cord-015922-5wwy0m2k 401 123 palivizumab palivizumab NNS cord-015922-5wwy0m2k 401 124 in in IN cord-015922-5wwy0m2k 401 125 recipients recipient NNS cord-015922-5wwy0m2k 401 126 of of IN cord-015922-5wwy0m2k 401 127 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 401 128 stem stem NN cord-015922-5wwy0m2k 401 129 cell cell NN cord-015922-5wwy0m2k 401 130 transplants transplant NNS cord-015922-5wwy0m2k 401 131 Detection detection NN cord-015922-5wwy0m2k 401 132 of of IN cord-015922-5wwy0m2k 401 133 rhinovirus rhinovirus NN cord-015922-5wwy0m2k 401 134 RNA RNA NNP cord-015922-5wwy0m2k 401 135 in in IN cord-015922-5wwy0m2k 401 136 bronchoalveolar bronchoalveolar NNP cord-015922-5wwy0m2k 401 137 lavage lavage NN cord-015922-5wwy0m2k 401 138 in in IN cord-015922-5wwy0m2k 401 139 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 401 140 stem stem NN cord-015922-5wwy0m2k 401 141 cell cell NN cord-015922-5wwy0m2k 401 142 transplant transplant NN cord-015922-5wwy0m2k 401 143 recipients recipient NNS cord-015922-5wwy0m2k 401 144 with with IN cord-015922-5wwy0m2k 401 145 pneumonia pneumonia NN cord-015922-5wwy0m2k 401 146 Rhinovirus Rhinovirus NNP cord-015922-5wwy0m2k 401 147 infections infection NNS cord-015922-5wwy0m2k 401 148 in in IN cord-015922-5wwy0m2k 401 149 myelosuppressed myelosuppressed JJ cord-015922-5wwy0m2k 401 150 adult adult NN cord-015922-5wwy0m2k 401 151 blood blood NN cord-015922-5wwy0m2k 401 152 and and CC cord-015922-5wwy0m2k 401 153 marrow marrow NN cord-015922-5wwy0m2k 401 154 transplant transplant NN cord-015922-5wwy0m2k 401 155 recipients recipient NNS cord-015922-5wwy0m2k 401 156 Community Community NNP cord-015922-5wwy0m2k 401 157 respiratory respiratory JJ cord-015922-5wwy0m2k 401 158 virus virus NN cord-015922-5wwy0m2k 401 159 infections infection NNS cord-015922-5wwy0m2k 401 160 in in IN cord-015922-5wwy0m2k 401 161 transplant transplant NN cord-015922-5wwy0m2k 401 162 recipients recipient NNS cord-015922-5wwy0m2k 401 163 Palivizumab Palivizumab NNP cord-015922-5wwy0m2k 401 164 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 401 165 to to TO cord-015922-5wwy0m2k 401 166 prevent prevent VB cord-015922-5wwy0m2k 401 167 respiratory respiratory JJ cord-015922-5wwy0m2k 401 168 syncytial syncytial JJ cord-015922-5wwy0m2k 401 169 virus virus NN cord-015922-5wwy0m2k 401 170 mortality mortality NN cord-015922-5wwy0m2k 401 171 after after IN cord-015922-5wwy0m2k 401 172 pediatric pediatric JJ cord-015922-5wwy0m2k 401 173 bone bone NN cord-015922-5wwy0m2k 401 174 marrow marrow NN cord-015922-5wwy0m2k 401 175 transplantation transplantation NN cord-015922-5wwy0m2k 401 176 : : : cord-015922-5wwy0m2k 401 177 a a DT cord-015922-5wwy0m2k 401 178 decision decision NN cord-015922-5wwy0m2k 401 179 analysis analysis NN cord-015922-5wwy0m2k 401 180 model model NN cord-015922-5wwy0m2k 401 181 Influenza Influenza NNP cord-015922-5wwy0m2k 401 182 infections infection NNS cord-015922-5wwy0m2k 401 183 after after IN cord-015922-5wwy0m2k 401 184 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 401 185 stem stem NN cord-015922-5wwy0m2k 401 186 cell cell NN cord-015922-5wwy0m2k 401 187 transplantation transplantation NN cord-015922-5wwy0m2k 401 188 : : : cord-015922-5wwy0m2k 401 189 risk risk NN cord-015922-5wwy0m2k 401 190 factors factor NNS cord-015922-5wwy0m2k 401 191 , , , cord-015922-5wwy0m2k 401 192 mortality mortality NN cord-015922-5wwy0m2k 401 193 , , , cord-015922-5wwy0m2k 401 194 and and CC cord-015922-5wwy0m2k 401 195 the the DT cord-015922-5wwy0m2k 401 196 effect effect NN cord-015922-5wwy0m2k 401 197 of of IN cord-015922-5wwy0m2k 401 198 antiviral antiviral JJ cord-015922-5wwy0m2k 401 199 therapy therapy NN cord-015922-5wwy0m2k 401 200 Hemorrhagic hemorrhagic NN cord-015922-5wwy0m2k 401 201 cystitis cystitis NN cord-015922-5wwy0m2k 401 202 in in IN cord-015922-5wwy0m2k 401 203 adults adult NNS cord-015922-5wwy0m2k 401 204 after after IN cord-015922-5wwy0m2k 401 205 unrelated unrelated JJ cord-015922-5wwy0m2k 401 206 cord cord NN cord-015922-5wwy0m2k 401 207 blood blood NN cord-015922-5wwy0m2k 401 208 transplantation transplantation NN cord-015922-5wwy0m2k 401 209 : : : cord-015922-5wwy0m2k 401 210 a a DT cord-015922-5wwy0m2k 401 211 single single JJ cord-015922-5wwy0m2k 401 212 - - HYPH cord-015922-5wwy0m2k 401 213 institution institution NN cord-015922-5wwy0m2k 401 214 experience experience NN cord-015922-5wwy0m2k 401 215 in in IN cord-015922-5wwy0m2k 401 216 Japan Japan NNP cord-015922-5wwy0m2k 401 217 Assessment Assessment NNP cord-015922-5wwy0m2k 401 218 of of IN cord-015922-5wwy0m2k 401 219 disseminated disseminate VBN cord-015922-5wwy0m2k 401 220 adenovirus adenovirus NN cord-015922-5wwy0m2k 401 221 infections infection NNS cord-015922-5wwy0m2k 401 222 using use VBG cord-015922-5wwy0m2k 401 223 quantitative quantitative JJ cord-015922-5wwy0m2k 401 224 plasma plasma NN cord-015922-5wwy0m2k 401 225 PCR PCR NNP cord-015922-5wwy0m2k 401 226 in in IN cord-015922-5wwy0m2k 401 227 adult adult NN cord-015922-5wwy0m2k 401 228 allogeneic allogeneic NN cord-015922-5wwy0m2k 401 229 stem stem NN cord-015922-5wwy0m2k 401 230 cell cell NN cord-015922-5wwy0m2k 401 231 transplant transplant NN cord-015922-5wwy0m2k 401 232 recipients recipient NNS cord-015922-5wwy0m2k 401 233 receiving receive VBG cord-015922-5wwy0m2k 401 234 reduced reduce VBN cord-015922-5wwy0m2k 401 235 intensity intensity NN cord-015922-5wwy0m2k 401 236 or or CC cord-015922-5wwy0m2k 401 237 myeloablative myeloablative JJ cord-015922-5wwy0m2k 401 238 conditioning conditioning NN cord-015922-5wwy0m2k 401 239 Cidofovir Cidofovir NNP cord-015922-5wwy0m2k 401 240 for for IN cord-015922-5wwy0m2k 401 241 adenovirus adenovirus NN cord-015922-5wwy0m2k 401 242 infections infection NNS cord-015922-5wwy0m2k 401 243 after after IN cord-015922-5wwy0m2k 401 244 allogeneic allogeneic JJ cord-015922-5wwy0m2k 401 245 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 401 246 stem stem NN cord-015922-5wwy0m2k 401 247 cell cell NN cord-015922-5wwy0m2k 401 248 transplantation transplantation NN cord-015922-5wwy0m2k 401 249 : : : cord-015922-5wwy0m2k 401 250 a a DT cord-015922-5wwy0m2k 401 251 survey survey NN cord-015922-5wwy0m2k 401 252 by by IN cord-015922-5wwy0m2k 401 253 the the DT cord-015922-5wwy0m2k 401 254 Infectious Infectious NNP cord-015922-5wwy0m2k 401 255 Diseases Diseases NNPS cord-015922-5wwy0m2k 401 256 Working Working NNP cord-015922-5wwy0m2k 401 257 Party Party NNP cord-015922-5wwy0m2k 401 258 of of IN cord-015922-5wwy0m2k 401 259 the the DT cord-015922-5wwy0m2k 401 260 European European NNP cord-015922-5wwy0m2k 401 261 Group Group NNP cord-015922-5wwy0m2k 401 262 for for IN cord-015922-5wwy0m2k 401 263 Blood Blood NNP cord-015922-5wwy0m2k 401 264 and and CC cord-015922-5wwy0m2k 401 265 Marrow Marrow NNP cord-015922-5wwy0m2k 401 266 Transplantation Transplantation NNP cord-015922-5wwy0m2k 401 267 Parainfluenza Parainfluenza NNP cord-015922-5wwy0m2k 401 268 virus virus NN cord-015922-5wwy0m2k 401 269 infections infection NNS cord-015922-5wwy0m2k 401 270 after after IN cord-015922-5wwy0m2k 401 271 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 401 272 stem stem NN cord-015922-5wwy0m2k 401 273 cell cell NN cord-015922-5wwy0m2k 401 274 transplantation transplantation NN cord-015922-5wwy0m2k 401 275 : : : cord-015922-5wwy0m2k 401 276 risk risk NN cord-015922-5wwy0m2k 401 277 factors factor NNS cord-015922-5wwy0m2k 401 278 , , , cord-015922-5wwy0m2k 401 279 response response NN cord-015922-5wwy0m2k 401 280 to to IN cord-015922-5wwy0m2k 401 281 antiviral antiviral JJ cord-015922-5wwy0m2k 401 282 therapy therapy NN cord-015922-5wwy0m2k 401 283 , , , cord-015922-5wwy0m2k 401 284 and and CC cord-015922-5wwy0m2k 401 285 effect effect NN cord-015922-5wwy0m2k 401 286 on on IN cord-015922-5wwy0m2k 401 287 transplant transplant NN cord-015922-5wwy0m2k 401 288 outcome outcome NN cord-015922-5wwy0m2k 401 289 Respiratory respiratory JJ cord-015922-5wwy0m2k 401 290 disease disease NN cord-015922-5wwy0m2k 401 291 due due JJ cord-015922-5wwy0m2k 401 292 to to IN cord-015922-5wwy0m2k 401 293 parainfluenza parainfluenza NNP cord-015922-5wwy0m2k 401 294 virus virus NN cord-015922-5wwy0m2k 401 295 in in IN cord-015922-5wwy0m2k 401 296 adult adult NN cord-015922-5wwy0m2k 401 297 bone bone NN cord-015922-5wwy0m2k 401 298 marrow marrow NN cord-015922-5wwy0m2k 401 299 transplant transplant NN cord-015922-5wwy0m2k 401 300 recipients recipient NNS cord-015922-5wwy0m2k 402 1 Ciprofloxacin Ciprofloxacin NNP cord-015922-5wwy0m2k 402 2 decreased decrease VBD cord-015922-5wwy0m2k 402 3 polyoma polyoma NNP cord-015922-5wwy0m2k 402 4 BK BK NNP cord-015922-5wwy0m2k 402 5 virus virus NN cord-015922-5wwy0m2k 402 6 load load NN cord-015922-5wwy0m2k 402 7 in in IN cord-015922-5wwy0m2k 402 8 patients patient NNS cord-015922-5wwy0m2k 402 9 who who WP cord-015922-5wwy0m2k 402 10 underwent undergo VBD cord-015922-5wwy0m2k 402 11 allogeneic allogeneic JJ cord-015922-5wwy0m2k 402 12 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 402 13 stem stem NN cord-015922-5wwy0m2k 402 14 cell cell NN cord-015922-5wwy0m2k 402 15 transplantation transplantation NN cord-015922-5wwy0m2k 402 16 Influence influence NN cord-015922-5wwy0m2k 402 17 of of IN cord-015922-5wwy0m2k 402 18 human human JJ cord-015922-5wwy0m2k 402 19 immunodeficiency immunodeficiency NN cord-015922-5wwy0m2k 402 20 virus virus NN cord-015922-5wwy0m2k 402 21 infection infection NN cord-015922-5wwy0m2k 402 22 on on IN cord-015922-5wwy0m2k 402 23 the the DT cord-015922-5wwy0m2k 402 24 course course NN cord-015922-5wwy0m2k 402 25 of of IN cord-015922-5wwy0m2k 402 26 hepatitis hepatitis NN cord-015922-5wwy0m2k 402 27 C C NNP cord-015922-5wwy0m2k 402 28 virus virus NN cord-015922-5wwy0m2k 402 29 infection infection NN cord-015922-5wwy0m2k 402 30 : : : cord-015922-5wwy0m2k 402 31 a a DT cord-015922-5wwy0m2k 402 32 meta meta JJ cord-015922-5wwy0m2k 402 33 - - HYPH cord-015922-5wwy0m2k 402 34 analysis analysis NN cord-015922-5wwy0m2k 402 35 A a DT cord-015922-5wwy0m2k 402 36 long long JJ cord-015922-5wwy0m2k 402 37 - - HYPH cord-015922-5wwy0m2k 402 38 term term NN cord-015922-5wwy0m2k 402 39 follow follow NN cord-015922-5wwy0m2k 402 40 - - HYPH cord-015922-5wwy0m2k 402 41 up up NN cord-015922-5wwy0m2k 402 42 study study NN cord-015922-5wwy0m2k 402 43 on on IN cord-015922-5wwy0m2k 402 44 hepatitis hepatitis NNP cord-015922-5wwy0m2k 402 45 B B NNP cord-015922-5wwy0m2k 402 46 surface surface NN cord-015922-5wwy0m2k 402 47 antigen antigen NN cord-015922-5wwy0m2k 402 48 - - HYPH cord-015922-5wwy0m2k 402 49 positive positive JJ cord-015922-5wwy0m2k 402 50 patients patient NNS cord-015922-5wwy0m2k 402 51 undergoing undergo VBG cord-015922-5wwy0m2k 402 52 allogeneic allogeneic IN cord-015922-5wwy0m2k 402 53 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 402 54 stem stem NN cord-015922-5wwy0m2k 402 55 cell cell NN cord-015922-5wwy0m2k 402 56 transplantation transplantation NN cord-015922-5wwy0m2k 402 57 Effectiveness Effectiveness NNP cord-015922-5wwy0m2k 402 58 of of IN cord-015922-5wwy0m2k 402 59 prophylactic prophylactic JJ cord-015922-5wwy0m2k 402 60 Anti Anti NNP cord-015922-5wwy0m2k 402 61 - - JJ cord-015922-5wwy0m2k 402 62 HBV HBV NNP cord-015922-5wwy0m2k 402 63 therapy therapy NN cord-015922-5wwy0m2k 402 64 in in IN cord-015922-5wwy0m2k 402 65 allogeneic allogeneic JJ cord-015922-5wwy0m2k 402 66 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 402 67 stem stem NN cord-015922-5wwy0m2k 402 68 cell cell NN cord-015922-5wwy0m2k 402 69 transplantation transplantation NN cord-015922-5wwy0m2k 402 70 with with IN cord-015922-5wwy0m2k 402 71 HBsAg hbsag ADD cord-015922-5wwy0m2k 402 72 positive positive JJ cord-015922-5wwy0m2k 402 73 donors donor NNS cord-015922-5wwy0m2k 402 74 Peginterferon Peginterferon NNP cord-015922-5wwy0m2k 402 75 Alfa-2a Alfa-2a NNP cord-015922-5wwy0m2k 402 76 , , , cord-015922-5wwy0m2k 402 77 lamivudine lamivudine JJ cord-015922-5wwy0m2k 402 78 , , , cord-015922-5wwy0m2k 402 79 and and CC cord-015922-5wwy0m2k 402 80 the the DT cord-015922-5wwy0m2k 402 81 combination combination NN cord-015922-5wwy0m2k 402 82 for for IN cord-015922-5wwy0m2k 402 83 HBeAg hbeag CD cord-015922-5wwy0m2k 402 84 - - HYPH cord-015922-5wwy0m2k 402 85 positive positive JJ cord-015922-5wwy0m2k 402 86 chronic chronic NN cord-015922-5wwy0m2k 402 87 hepatitis hepatitis NN cord-015922-5wwy0m2k 402 88 B B NNP cord-015922-5wwy0m2k 402 89 Entecavir Entecavir NNP cord-015922-5wwy0m2k 402 90 versus versus IN cord-015922-5wwy0m2k 402 91 lamivudine lamivudine NN cord-015922-5wwy0m2k 402 92 for for IN cord-015922-5wwy0m2k 402 93 patients patient NNS cord-015922-5wwy0m2k 402 94 with with IN cord-015922-5wwy0m2k 402 95 HBeAg hbeag CD cord-015922-5wwy0m2k 402 96 - - HYPH cord-015922-5wwy0m2k 402 97 negative negative JJ cord-015922-5wwy0m2k 402 98 chronic chronic JJ cord-015922-5wwy0m2k 402 99 hepatitis hepatitis NN cord-015922-5wwy0m2k 402 100 B B NNP cord-015922-5wwy0m2k 402 101 A a DT cord-015922-5wwy0m2k 402 102 comparison comparison NN cord-015922-5wwy0m2k 402 103 of of IN cord-015922-5wwy0m2k 402 104 entecavir entecavir NNP cord-015922-5wwy0m2k 402 105 and and CC cord-015922-5wwy0m2k 402 106 lamivudine lamivudine NNP cord-015922-5wwy0m2k 402 107 for for IN cord-015922-5wwy0m2k 402 108 HBeAg hbeag CD cord-015922-5wwy0m2k 402 109 - - HYPH cord-015922-5wwy0m2k 402 110 positive positive JJ cord-015922-5wwy0m2k 402 111 chronic chronic NN cord-015922-5wwy0m2k 402 112 hepatitis hepatitis NN cord-015922-5wwy0m2k 402 113 B B NNP cord-015922-5wwy0m2k 402 114 Long long JJ cord-015922-5wwy0m2k 402 115 - - HYPH cord-015922-5wwy0m2k 402 116 term term NN cord-015922-5wwy0m2k 402 117 therapy therapy NN cord-015922-5wwy0m2k 402 118 with with IN cord-015922-5wwy0m2k 402 119 adefovir adefovir NNP cord-015922-5wwy0m2k 403 1 dipivoxil dipivoxil NNP cord-015922-5wwy0m2k 403 2 for for IN cord-015922-5wwy0m2k 403 3 HBeAg hbeag CD cord-015922-5wwy0m2k 403 4 - - HYPH cord-015922-5wwy0m2k 403 5 negative negative JJ cord-015922-5wwy0m2k 403 6 chronic chronic JJ cord-015922-5wwy0m2k 403 7 hepatitis hepatitis NN cord-015922-5wwy0m2k 403 8 B B NNP cord-015922-5wwy0m2k 403 9 Long long JJ cord-015922-5wwy0m2k 403 10 - - HYPH cord-015922-5wwy0m2k 403 11 term term NN cord-015922-5wwy0m2k 403 12 outcome outcome NN cord-015922-5wwy0m2k 403 13 of of IN cord-015922-5wwy0m2k 403 14 hepatitis hepatitis NN cord-015922-5wwy0m2k 403 15 C C NNP cord-015922-5wwy0m2k 403 16 infection infection NN cord-015922-5wwy0m2k 403 17 after after IN cord-015922-5wwy0m2k 403 18 bone bone NN cord-015922-5wwy0m2k 403 19 marrow marrow NN cord-015922-5wwy0m2k 403 20 transplantation transplantation NN cord-015922-5wwy0m2k 404 1 Hepatitis hepatitis NN cord-015922-5wwy0m2k 404 2 reactivation reactivation NN cord-015922-5wwy0m2k 404 3 and and CC cord-015922-5wwy0m2k 404 4 liver liver NN cord-015922-5wwy0m2k 404 5 failure failure NN cord-015922-5wwy0m2k 404 6 in in IN cord-015922-5wwy0m2k 404 7 haemopoietic haemopoietic JJ cord-015922-5wwy0m2k 404 8 stem stem NN cord-015922-5wwy0m2k 404 9 cell cell NN cord-015922-5wwy0m2k 404 10 transplants transplant NNS cord-015922-5wwy0m2k 404 11 for for IN cord-015922-5wwy0m2k 404 12 hepatitis hepatitis NN cord-015922-5wwy0m2k 404 13 B B NNP cord-015922-5wwy0m2k 404 14 virus virus NN cord-015922-5wwy0m2k 404 15 ( ( -LRB- cord-015922-5wwy0m2k 404 16 HBV)/hepatitis HBV)/hepatitis NNP cord-015922-5wwy0m2k 404 17 C C NNP cord-015922-5wwy0m2k 404 18 virus virus NN cord-015922-5wwy0m2k 404 19 ( ( -LRB- cord-015922-5wwy0m2k 404 20 HCV HCV NNP cord-015922-5wwy0m2k 404 21 ) ) -RRB- cord-015922-5wwy0m2k 404 22 positive positive JJ cord-015922-5wwy0m2k 404 23 recipients recipient NNS cord-015922-5wwy0m2k 404 24 : : : cord-015922-5wwy0m2k 405 1 a a DT cord-015922-5wwy0m2k 405 2 retrospective retrospective JJ cord-015922-5wwy0m2k 405 3 study study NN cord-015922-5wwy0m2k 405 4 by by IN cord-015922-5wwy0m2k 405 5 the the DT cord-015922-5wwy0m2k 405 6 Italian italian JJ cord-015922-5wwy0m2k 405 7 group group NN cord-015922-5wwy0m2k 405 8 for for IN cord-015922-5wwy0m2k 405 9 blood blood NN cord-015922-5wwy0m2k 405 10 and and CC cord-015922-5wwy0m2k 405 11 marrow marrow NN cord-015922-5wwy0m2k 405 12 transplantation transplantation NN cord-015922-5wwy0m2k 405 13 Hepatitis Hepatitis NNP cord-015922-5wwy0m2k 405 14 C C NNP cord-015922-5wwy0m2k 405 15 virus virus NN cord-015922-5wwy0m2k 405 16 infection infection NN cord-015922-5wwy0m2k 405 17 is be VBZ cord-015922-5wwy0m2k 405 18 a a DT cord-015922-5wwy0m2k 405 19 risk risk NN cord-015922-5wwy0m2k 405 20 factor factor NN cord-015922-5wwy0m2k 405 21 for for IN cord-015922-5wwy0m2k 405 22 liver liver NN cord-015922-5wwy0m2k 405 23 failure failure NN cord-015922-5wwy0m2k 405 24 from from IN cord-015922-5wwy0m2k 405 25 veno veno NNP cord-015922-5wwy0m2k 405 26 - - HYPH cord-015922-5wwy0m2k 405 27 occlusive occlusive JJ cord-015922-5wwy0m2k 405 28 disease disease NN cord-015922-5wwy0m2k 405 29 after after IN cord-015922-5wwy0m2k 405 30 bone bone NN cord-015922-5wwy0m2k 405 31 marrow marrow NN cord-015922-5wwy0m2k 405 32 transplantation transplantation NN cord-015922-5wwy0m2k 405 33 Guidelines guideline NNS cord-015922-5wwy0m2k 405 34 for for IN cord-015922-5wwy0m2k 405 35 treatment treatment NN cord-015922-5wwy0m2k 405 36 of of IN cord-015922-5wwy0m2k 405 37 candidiasis candidiasis NN cord-015922-5wwy0m2k 406 1 Should Should MD cord-015922-5wwy0m2k 406 2 vascular vascular JJ cord-015922-5wwy0m2k 406 3 catheters catheter NNS cord-015922-5wwy0m2k 406 4 be be VB cord-015922-5wwy0m2k 406 5 removed remove VBN cord-015922-5wwy0m2k 406 6 from from IN cord-015922-5wwy0m2k 406 7 all all DT cord-015922-5wwy0m2k 406 8 patients patient NNS cord-015922-5wwy0m2k 406 9 with with IN cord-015922-5wwy0m2k 406 10 candidemia candidemia NN cord-015922-5wwy0m2k 406 11 ? ? . cord-015922-5wwy0m2k 407 1 An an DT cord-015922-5wwy0m2k 407 2 evidence evidence NN cord-015922-5wwy0m2k 407 3 - - HYPH cord-015922-5wwy0m2k 407 4 based base VBN cord-015922-5wwy0m2k 407 5 review review NN cord-015922-5wwy0m2k 407 6 Efficacy Efficacy NNP cord-015922-5wwy0m2k 407 7 and and CC cord-015922-5wwy0m2k 407 8 safety safety NN cord-015922-5wwy0m2k 407 9 of of IN cord-015922-5wwy0m2k 407 10 fluconazole fluconazole NN cord-015922-5wwy0m2k 407 11 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 407 12 for for IN cord-015922-5wwy0m2k 407 13 fungal fungal JJ cord-015922-5wwy0m2k 407 14 infections infection NNS cord-015922-5wwy0m2k 407 15 after after IN cord-015922-5wwy0m2k 407 16 marrow marrow NN cord-015922-5wwy0m2k 407 17 transplantation transplantation NN cord-015922-5wwy0m2k 407 18 - - : cord-015922-5wwy0m2k 407 19 a a DT cord-015922-5wwy0m2k 407 20 prospective prospective NN cord-015922-5wwy0m2k 407 21 , , , cord-015922-5wwy0m2k 407 22 randomized randomized JJ cord-015922-5wwy0m2k 407 23 , , , cord-015922-5wwy0m2k 407 24 double double JJ cord-015922-5wwy0m2k 407 25 - - HYPH cord-015922-5wwy0m2k 407 26 blind blind JJ cord-015922-5wwy0m2k 407 27 study study NN cord-015922-5wwy0m2k 408 1 A a DT cord-015922-5wwy0m2k 408 2 controlled control VBN cord-015922-5wwy0m2k 408 3 trial trial NN cord-015922-5wwy0m2k 408 4 of of IN cord-015922-5wwy0m2k 408 5 fluconazole fluconazole NN cord-015922-5wwy0m2k 408 6 to to TO cord-015922-5wwy0m2k 408 7 prevent prevent VB cord-015922-5wwy0m2k 408 8 fungal fungal JJ cord-015922-5wwy0m2k 408 9 infections infection NNS cord-015922-5wwy0m2k 408 10 in in IN cord-015922-5wwy0m2k 408 11 patients patient NNS cord-015922-5wwy0m2k 408 12 undergoing undergo VBG cord-015922-5wwy0m2k 408 13 bone bone NN cord-015922-5wwy0m2k 408 14 marrow marrow NN cord-015922-5wwy0m2k 408 15 transplantation transplantation NN cord-015922-5wwy0m2k 408 16 Infections infection NNS cord-015922-5wwy0m2k 408 17 in in IN cord-015922-5wwy0m2k 408 18 the the DT cord-015922-5wwy0m2k 408 19 neutropenic neutropenic JJ cord-015922-5wwy0m2k 408 20 patient patient JJ cord-015922-5wwy0m2k 408 21 - - HYPH cord-015922-5wwy0m2k 408 22 new new JJ cord-015922-5wwy0m2k 408 23 views view NNS cord-015922-5wwy0m2k 408 24 of of IN cord-015922-5wwy0m2k 408 25 an an DT cord-015922-5wwy0m2k 408 26 old old JJ cord-015922-5wwy0m2k 408 27 problem problem NN cord-015922-5wwy0m2k 408 28 . . . cord-015922-5wwy0m2k 409 1 Hematology Hematology NNP cord-015922-5wwy0m2k 409 2 / / , cord-015922-5wwy0m2k 409 3 the the DT cord-015922-5wwy0m2k 409 4 Education Education NNP cord-015922-5wwy0m2k 409 5 Program Program NNP cord-015922-5wwy0m2k 409 6 of of IN cord-015922-5wwy0m2k 409 7 the the DT cord-015922-5wwy0m2k 409 8 Fungal fungal JJ cord-015922-5wwy0m2k 409 9 infections infection NNS cord-015922-5wwy0m2k 409 10 in in IN cord-015922-5wwy0m2k 409 11 granulocytopenic granulocytopenic NN cord-015922-5wwy0m2k 409 12 patients patient NNS cord-015922-5wwy0m2k 409 13 : : : cord-015922-5wwy0m2k 409 14 current current JJ cord-015922-5wwy0m2k 409 15 approaches approach NNS cord-015922-5wwy0m2k 409 16 to to IN cord-015922-5wwy0m2k 409 17 classifications classification NNS cord-015922-5wwy0m2k 409 18 , , , cord-015922-5wwy0m2k 409 19 diagnosis diagnosis NN cord-015922-5wwy0m2k 409 20 Candidemia Candidemia NNP cord-015922-5wwy0m2k 409 21 in in IN cord-015922-5wwy0m2k 409 22 immunocompromised immunocompromised JJ cord-015922-5wwy0m2k 409 23 patients patient NNS cord-015922-5wwy0m2k 410 1 Infections infection NNS cord-015922-5wwy0m2k 410 2 due due JJ cord-015922-5wwy0m2k 410 3 to to IN cord-015922-5wwy0m2k 410 4 resistant resistant JJ cord-015922-5wwy0m2k 410 5 Candida Candida NNP cord-015922-5wwy0m2k 410 6 species specie NNS cord-015922-5wwy0m2k 410 7 in in IN cord-015922-5wwy0m2k 410 8 patients patient NNS cord-015922-5wwy0m2k 410 9 with with IN cord-015922-5wwy0m2k 410 10 cancer cancer NN cord-015922-5wwy0m2k 410 11 who who WP cord-015922-5wwy0m2k 410 12 are be VBP cord-015922-5wwy0m2k 410 13 receiving receive VBG cord-015922-5wwy0m2k 410 14 chemotherapy chemotherapy NN cord-015922-5wwy0m2k 410 15 Prospective prospective JJ cord-015922-5wwy0m2k 410 16 study study NN cord-015922-5wwy0m2k 410 17 of of IN cord-015922-5wwy0m2k 410 18 Candida Candida NNP cord-015922-5wwy0m2k 410 19 endophthalmitis endophthalmitis NN cord-015922-5wwy0m2k 410 20 in in IN cord-015922-5wwy0m2k 410 21 hospitalized hospitalize VBN cord-015922-5wwy0m2k 410 22 patients patient NNS cord-015922-5wwy0m2k 410 23 with with IN cord-015922-5wwy0m2k 410 24 candidemia candidemia NNP cord-015922-5wwy0m2k 410 25 Risk Risk NNP cord-015922-5wwy0m2k 410 26 factors factor NNS cord-015922-5wwy0m2k 410 27 for for IN cord-015922-5wwy0m2k 410 28 hepatosplenic hepatosplenic JJ cord-015922-5wwy0m2k 410 29 abscesses abscess NNS cord-015922-5wwy0m2k 410 30 in in IN cord-015922-5wwy0m2k 410 31 patients patient NNS cord-015922-5wwy0m2k 410 32 with with IN cord-015922-5wwy0m2k 410 33 acute acute JJ cord-015922-5wwy0m2k 410 34 leukemia leukemia NN cord-015922-5wwy0m2k 410 35 receiving receive VBG cord-015922-5wwy0m2k 410 36 empiric empiric JJ cord-015922-5wwy0m2k 410 37 azole azole NNP cord-015922-5wwy0m2k 410 38 treatment treatment NN cord-015922-5wwy0m2k 410 39 Practice Practice NNP cord-015922-5wwy0m2k 410 40 guidelines guideline NNS cord-015922-5wwy0m2k 410 41 for for IN cord-015922-5wwy0m2k 410 42 the the DT cord-015922-5wwy0m2k 410 43 treatment treatment NN cord-015922-5wwy0m2k 410 44 of of IN cord-015922-5wwy0m2k 410 45 candidiasis candidiasi NNS cord-015922-5wwy0m2k 410 46 . . . cord-015922-5wwy0m2k 411 1 Infectious Infectious NNP cord-015922-5wwy0m2k 411 2 Diseases Diseases NNPS cord-015922-5wwy0m2k 411 3 Society Society NNP cord-015922-5wwy0m2k 411 4 of of IN cord-015922-5wwy0m2k 411 5 America America NNP cord-015922-5wwy0m2k 411 6 Disseminated disseminate VBN cord-015922-5wwy0m2k 411 7 trichosporonosis trichosporonosis NN cord-015922-5wwy0m2k 411 8 caused cause VBN cord-015922-5wwy0m2k 411 9 by by IN cord-015922-5wwy0m2k 411 10 Trichosporon Trichosporon NNP cord-015922-5wwy0m2k 411 11 loubieri loubieri NN cord-015922-5wwy0m2k 411 12 Micafungin Micafungin NNP cord-015922-5wwy0m2k 411 13 versus versus IN cord-015922-5wwy0m2k 411 14 fluconazole fluconazole NN cord-015922-5wwy0m2k 411 15 for for IN cord-015922-5wwy0m2k 411 16 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 411 17 against against IN cord-015922-5wwy0m2k 411 18 invasive invasive JJ cord-015922-5wwy0m2k 411 19 fungal fungal JJ cord-015922-5wwy0m2k 411 20 infections infection NNS cord-015922-5wwy0m2k 411 21 during during IN cord-015922-5wwy0m2k 411 22 neutropenia neutropenia NN cord-015922-5wwy0m2k 411 23 in in IN cord-015922-5wwy0m2k 411 24 patients patient NNS cord-015922-5wwy0m2k 411 25 undergoing undergo VBG cord-015922-5wwy0m2k 411 26 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 411 27 stem stem NN cord-015922-5wwy0m2k 411 28 cell cell NN cord-015922-5wwy0m2k 411 29 transplantation transplantation NN cord-015922-5wwy0m2k 411 30 Caspofungin Caspofungin NNP cord-015922-5wwy0m2k 411 31 versus versus IN cord-015922-5wwy0m2k 411 32 liposomal liposomal JJ cord-015922-5wwy0m2k 411 33 amphotericin amphotericin NNS cord-015922-5wwy0m2k 411 34 B B NNP cord-015922-5wwy0m2k 411 35 for for IN cord-015922-5wwy0m2k 411 36 empirical empirical JJ cord-015922-5wwy0m2k 411 37 antifungal antifungal JJ cord-015922-5wwy0m2k 411 38 therapy therapy NN cord-015922-5wwy0m2k 411 39 in in IN cord-015922-5wwy0m2k 411 40 patients patient NNS cord-015922-5wwy0m2k 411 41 with with IN cord-015922-5wwy0m2k 411 42 persistent persistent JJ cord-015922-5wwy0m2k 411 43 fever fever NN cord-015922-5wwy0m2k 411 44 and and CC cord-015922-5wwy0m2k 411 45 neutropenia neutropenia NN cord-015922-5wwy0m2k 411 46 Breakthrough Breakthrough NNP cord-015922-5wwy0m2k 411 47 trichosporonosis trichosporonosis NN cord-015922-5wwy0m2k 411 48 in in IN cord-015922-5wwy0m2k 411 49 patients patient NNS cord-015922-5wwy0m2k 411 50 with with IN cord-015922-5wwy0m2k 411 51 hematologic hematologic JJ cord-015922-5wwy0m2k 411 52 malignancies malignancy NNS cord-015922-5wwy0m2k 411 53 receiving receive VBG cord-015922-5wwy0m2k 411 54 micafungin micafungin NNP cord-015922-5wwy0m2k 411 55 Epidemiology Epidemiology NNP cord-015922-5wwy0m2k 411 56 of of IN cord-015922-5wwy0m2k 411 57 Aspergillus Aspergillus NNP cord-015922-5wwy0m2k 411 58 infections infection NNS cord-015922-5wwy0m2k 411 59 in in IN cord-015922-5wwy0m2k 411 60 a a DT cord-015922-5wwy0m2k 411 61 large large JJ cord-015922-5wwy0m2k 411 62 cohort cohort NN cord-015922-5wwy0m2k 411 63 of of IN cord-015922-5wwy0m2k 411 64 patients patient NNS cord-015922-5wwy0m2k 411 65 undergoing undergo VBG cord-015922-5wwy0m2k 411 66 bone bone NN cord-015922-5wwy0m2k 411 67 marrow marrow NN cord-015922-5wwy0m2k 411 68 transplantation transplantation NN cord-015922-5wwy0m2k 411 69 Candidemia Candidemia NNP cord-015922-5wwy0m2k 411 70 in in IN cord-015922-5wwy0m2k 411 71 allogeneic allogeneic NN cord-015922-5wwy0m2k 411 72 blood blood NN cord-015922-5wwy0m2k 411 73 and and CC cord-015922-5wwy0m2k 411 74 marrow marrow NN cord-015922-5wwy0m2k 411 75 transplant transplant NN cord-015922-5wwy0m2k 411 76 recipients recipient NNS cord-015922-5wwy0m2k 411 77 : : : cord-015922-5wwy0m2k 411 78 evolution evolution NN cord-015922-5wwy0m2k 411 79 of of IN cord-015922-5wwy0m2k 411 80 risk risk NN cord-015922-5wwy0m2k 411 81 factors factor NNS cord-015922-5wwy0m2k 411 82 after after IN cord-015922-5wwy0m2k 411 83 the the DT cord-015922-5wwy0m2k 411 84 adoption adoption NN cord-015922-5wwy0m2k 411 85 of of IN cord-015922-5wwy0m2k 411 86 prophylactic prophylactic JJ cord-015922-5wwy0m2k 411 87 fluconazole fluconazole NNP cord-015922-5wwy0m2k 411 88 Prevention Prevention NNP cord-015922-5wwy0m2k 411 89 and and CC cord-015922-5wwy0m2k 411 90 early early JJ cord-015922-5wwy0m2k 411 91 treatment treatment NN cord-015922-5wwy0m2k 411 92 of of IN cord-015922-5wwy0m2k 411 93 invasive invasive JJ cord-015922-5wwy0m2k 411 94 fungal fungal JJ cord-015922-5wwy0m2k 411 95 infection infection NN cord-015922-5wwy0m2k 411 96 in in IN cord-015922-5wwy0m2k 411 97 patients patient NNS cord-015922-5wwy0m2k 411 98 with with IN cord-015922-5wwy0m2k 411 99 cancer cancer NN cord-015922-5wwy0m2k 411 100 and and CC cord-015922-5wwy0m2k 411 101 neutropenia neutropenia NN cord-015922-5wwy0m2k 411 102 and and CC cord-015922-5wwy0m2k 411 103 in in IN cord-015922-5wwy0m2k 411 104 stem stem NN cord-015922-5wwy0m2k 411 105 cell cell NN cord-015922-5wwy0m2k 411 106 transplant transplant NN cord-015922-5wwy0m2k 411 107 recipients recipient NNS cord-015922-5wwy0m2k 411 108 in in IN cord-015922-5wwy0m2k 411 109 the the DT cord-015922-5wwy0m2k 411 110 era era NN cord-015922-5wwy0m2k 411 111 of of IN cord-015922-5wwy0m2k 411 112 newer new JJR cord-015922-5wwy0m2k 411 113 broad broad JJ cord-015922-5wwy0m2k 411 114 - - HYPH cord-015922-5wwy0m2k 411 115 spectrum spectrum NN cord-015922-5wwy0m2k 411 116 antifungal antifungal JJ cord-015922-5wwy0m2k 411 117 agents agent NNS cord-015922-5wwy0m2k 411 118 and and CC cord-015922-5wwy0m2k 411 119 diagnostic diagnostic JJ cord-015922-5wwy0m2k 411 120 adjuncts adjunct NNS cord-015922-5wwy0m2k 412 1 Defining define VBG cord-015922-5wwy0m2k 412 2 opportunistic opportunistic JJ cord-015922-5wwy0m2k 412 3 invasive invasive JJ cord-015922-5wwy0m2k 412 4 fungal fungal JJ cord-015922-5wwy0m2k 412 5 infections infection NNS cord-015922-5wwy0m2k 412 6 in in IN cord-015922-5wwy0m2k 412 7 immunocompromised immunocompromised JJ cord-015922-5wwy0m2k 412 8 patients patient NNS cord-015922-5wwy0m2k 412 9 with with IN cord-015922-5wwy0m2k 412 10 cancer cancer NN cord-015922-5wwy0m2k 412 11 and and CC cord-015922-5wwy0m2k 412 12 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 412 13 stem stem NN cord-015922-5wwy0m2k 412 14 cell cell NN cord-015922-5wwy0m2k 412 15 transplants transplant NNS cord-015922-5wwy0m2k 412 16 : : : cord-015922-5wwy0m2k 413 1 an an DT cord-015922-5wwy0m2k 413 2 international international JJ cord-015922-5wwy0m2k 413 3 consensus consensus NN cord-015922-5wwy0m2k 413 4 Should Should MD cord-015922-5wwy0m2k 413 5 the the DT cord-015922-5wwy0m2k 413 6 consensus consensus NN cord-015922-5wwy0m2k 413 7 guidelines guideline NNS cord-015922-5wwy0m2k 413 8 ' ' POS cord-015922-5wwy0m2k 413 9 specific specific JJ cord-015922-5wwy0m2k 413 10 criteria criterion NNS cord-015922-5wwy0m2k 413 11 for for IN cord-015922-5wwy0m2k 413 12 the the DT cord-015922-5wwy0m2k 413 13 diagnosis diagnosis NN cord-015922-5wwy0m2k 413 14 of of IN cord-015922-5wwy0m2k 413 15 invasive invasive JJ cord-015922-5wwy0m2k 413 16 fungal fungal JJ cord-015922-5wwy0m2k 413 17 infection infection NN cord-015922-5wwy0m2k 413 18 be be VB cord-015922-5wwy0m2k 413 19 changed change VBN cord-015922-5wwy0m2k 413 20 ? ? . cord-015922-5wwy0m2k 414 1 Reactivity reactivity NN cord-015922-5wwy0m2k 414 2 of of IN cord-015922-5wwy0m2k 414 3 ( ( -LRB- cord-015922-5wwy0m2k 414 4 1->3)-beta 1->3)-beta CD cord-015922-5wwy0m2k 414 5 - - HYPH cord-015922-5wwy0m2k 414 6 d d NN cord-015922-5wwy0m2k 414 7 - - HYPH cord-015922-5wwy0m2k 414 8 glucan glucan JJ cord-015922-5wwy0m2k 414 9 assay assay NN cord-015922-5wwy0m2k 414 10 with with IN cord-015922-5wwy0m2k 414 11 commonly commonly RB cord-015922-5wwy0m2k 414 12 used use VBN cord-015922-5wwy0m2k 414 13 intravenous intravenous JJ cord-015922-5wwy0m2k 414 14 antimicrobials antimicrobial NNS cord-015922-5wwy0m2k 414 15 Increasing increase VBG cord-015922-5wwy0m2k 414 16 volume volume NN cord-015922-5wwy0m2k 414 17 and and CC cord-015922-5wwy0m2k 414 18 changing change VBG cord-015922-5wwy0m2k 414 19 characteristics characteristic NNS cord-015922-5wwy0m2k 414 20 of of IN cord-015922-5wwy0m2k 414 21 invasive invasive JJ cord-015922-5wwy0m2k 414 22 pulmonary pulmonary JJ cord-015922-5wwy0m2k 414 23 aspergillosis aspergillosis NN cord-015922-5wwy0m2k 414 24 on on IN cord-015922-5wwy0m2k 414 25 sequential sequential JJ cord-015922-5wwy0m2k 414 26 thoracic thoracic JJ cord-015922-5wwy0m2k 414 27 computed compute VBN cord-015922-5wwy0m2k 414 28 tomography tomography NN cord-015922-5wwy0m2k 414 29 scans scan NNS cord-015922-5wwy0m2k 414 30 in in IN cord-015922-5wwy0m2k 414 31 patients patient NNS cord-015922-5wwy0m2k 414 32 with with IN cord-015922-5wwy0m2k 414 33 neutropenia neutropenia NN cord-015922-5wwy0m2k 414 34 Empiric Empiric NNP cord-015922-5wwy0m2k 414 35 antibiotic antibiotic JJ cord-015922-5wwy0m2k 414 36 and and CC cord-015922-5wwy0m2k 414 37 antifungal antifungal JJ cord-015922-5wwy0m2k 414 38 therapy therapy NN cord-015922-5wwy0m2k 414 39 for for IN cord-015922-5wwy0m2k 414 40 cancer cancer NN cord-015922-5wwy0m2k 414 41 patients patient NNS cord-015922-5wwy0m2k 414 42 with with IN cord-015922-5wwy0m2k 414 43 prolonged prolonged JJ cord-015922-5wwy0m2k 414 44 fever fever NN cord-015922-5wwy0m2k 414 45 and and CC cord-015922-5wwy0m2k 414 46 granulocytopenia granulocytopenia NNP cord-015922-5wwy0m2k 414 47 Empiric Empiric NNP cord-015922-5wwy0m2k 414 48 antifungal antifungal JJ cord-015922-5wwy0m2k 414 49 therapy therapy NN cord-015922-5wwy0m2k 414 50 in in IN cord-015922-5wwy0m2k 414 51 febrile febrile JJ cord-015922-5wwy0m2k 414 52 granulocytopenic granulocytopenic NN cord-015922-5wwy0m2k 414 53 patients patient NNS cord-015922-5wwy0m2k 414 54 . . . cord-015922-5wwy0m2k 415 1 EORTC EORTC NNP cord-015922-5wwy0m2k 415 2 International International NNP cord-015922-5wwy0m2k 415 3 Antimicrobial Antimicrobial NNP cord-015922-5wwy0m2k 415 4 Therapy Therapy NNP cord-015922-5wwy0m2k 415 5 Cooperative Cooperative NNP cord-015922-5wwy0m2k 415 6 Group Group NNP cord-015922-5wwy0m2k 415 7 Liposomal Liposomal NNP cord-015922-5wwy0m2k 415 8 amphotericin amphotericin NNS cord-015922-5wwy0m2k 415 9 B b NN cord-015922-5wwy0m2k 415 10 for for IN cord-015922-5wwy0m2k 415 11 empirical empirical JJ cord-015922-5wwy0m2k 415 12 therapy therapy NN cord-015922-5wwy0m2k 415 13 in in IN cord-015922-5wwy0m2k 415 14 patients patient NNS cord-015922-5wwy0m2k 415 15 with with IN cord-015922-5wwy0m2k 415 16 persistent persistent JJ cord-015922-5wwy0m2k 415 17 fever fever NN cord-015922-5wwy0m2k 415 18 and and CC cord-015922-5wwy0m2k 415 19 neutropenia neutropenia NN cord-015922-5wwy0m2k 415 20 . . . cord-015922-5wwy0m2k 416 1 National National NNP cord-015922-5wwy0m2k 416 2 Institute Institute NNP cord-015922-5wwy0m2k 416 3 of of IN cord-015922-5wwy0m2k 416 4 Allergy Allergy NNP cord-015922-5wwy0m2k 416 5 and and CC cord-015922-5wwy0m2k 416 6 Infectious Infectious NNP cord-015922-5wwy0m2k 416 7 Diseases Diseases NNPS cord-015922-5wwy0m2k 417 1 Mycoses Mycoses NNP cord-015922-5wwy0m2k 417 2 Study Study NNP cord-015922-5wwy0m2k 417 3 Group Group NNP cord-015922-5wwy0m2k 417 4 Voriconazole Voriconazole NNP cord-015922-5wwy0m2k 417 5 compared compare VBN cord-015922-5wwy0m2k 417 6 with with IN cord-015922-5wwy0m2k 417 7 liposomal liposomal JJ cord-015922-5wwy0m2k 417 8 amphotericin amphotericin NNS cord-015922-5wwy0m2k 417 9 B b NN cord-015922-5wwy0m2k 417 10 for for IN cord-015922-5wwy0m2k 417 11 empirical empirical JJ cord-015922-5wwy0m2k 417 12 antifungal antifungal JJ cord-015922-5wwy0m2k 417 13 therapy therapy NN cord-015922-5wwy0m2k 417 14 in in IN cord-015922-5wwy0m2k 417 15 patients patient NNS cord-015922-5wwy0m2k 417 16 with with IN cord-015922-5wwy0m2k 417 17 neutropenia neutropenia NN cord-015922-5wwy0m2k 417 18 and and CC cord-015922-5wwy0m2k 417 19 persistent persistent JJ cord-015922-5wwy0m2k 417 20 fever fever NN cord-015922-5wwy0m2k 417 21 Voriconazole Voriconazole NNP cord-015922-5wwy0m2k 417 22 versus versus IN cord-015922-5wwy0m2k 417 23 amphotericin amphotericin NNS cord-015922-5wwy0m2k 417 24 B b NN cord-015922-5wwy0m2k 417 25 for for IN cord-015922-5wwy0m2k 417 26 primary primary JJ cord-015922-5wwy0m2k 417 27 therapy therapy NN cord-015922-5wwy0m2k 417 28 of of IN cord-015922-5wwy0m2k 417 29 invasive invasive JJ cord-015922-5wwy0m2k 417 30 aspergillosis aspergillosis NN cord-015922-5wwy0m2k 417 31 Voriconazole Voriconazole NNP cord-015922-5wwy0m2k 417 32 and and CC cord-015922-5wwy0m2k 417 33 sirolimus sirolimus NNP cord-015922-5wwy0m2k 417 34 coadministration coadministration NN cord-015922-5wwy0m2k 417 35 after after IN cord-015922-5wwy0m2k 417 36 allogeneic allogeneic JJ cord-015922-5wwy0m2k 417 37 hematopoietic hematopoietic JJ cord-015922-5wwy0m2k 417 38 stem stem NN cord-015922-5wwy0m2k 417 39 cell cell NN cord-015922-5wwy0m2k 417 40 transplantation transplantation NN cord-015922-5wwy0m2k 417 41 Torsades Torsades NNP cord-015922-5wwy0m2k 417 42 de de IN cord-015922-5wwy0m2k 417 43 pointes pointes FW cord-015922-5wwy0m2k 417 44 associated associate VBN cord-015922-5wwy0m2k 417 45 with with IN cord-015922-5wwy0m2k 417 46 voriconazole voriconazole NNP cord-015922-5wwy0m2k 417 47 use use VBP cord-015922-5wwy0m2k 417 48 Salvage salvage NN cord-015922-5wwy0m2k 417 49 therapy therapy NN cord-015922-5wwy0m2k 417 50 with with IN cord-015922-5wwy0m2k 417 51 voriconazole voriconazole NN cord-015922-5wwy0m2k 417 52 for for IN cord-015922-5wwy0m2k 417 53 invasive invasive JJ cord-015922-5wwy0m2k 417 54 fungal fungal JJ cord-015922-5wwy0m2k 417 55 infections infection NNS cord-015922-5wwy0m2k 417 56 in in IN cord-015922-5wwy0m2k 417 57 patients patient NNS cord-015922-5wwy0m2k 417 58 failing fail VBG cord-015922-5wwy0m2k 417 59 or or CC cord-015922-5wwy0m2k 417 60 intolerant intolerant JJ cord-015922-5wwy0m2k 417 61 to to IN cord-015922-5wwy0m2k 417 62 standard standard JJ cord-015922-5wwy0m2k 417 63 antifungal antifungal JJ cord-015922-5wwy0m2k 417 64 therapy therapy NN cord-015922-5wwy0m2k 417 65 Posaconazole Posaconazole NNP cord-015922-5wwy0m2k 417 66 or or CC cord-015922-5wwy0m2k 417 67 fluconazole fluconazole NN cord-015922-5wwy0m2k 417 68 for for IN cord-015922-5wwy0m2k 417 69 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 417 70 in in IN cord-015922-5wwy0m2k 417 71 severe severe JJ cord-015922-5wwy0m2k 417 72 graft graft NN cord-015922-5wwy0m2k 417 73 - - HYPH cord-015922-5wwy0m2k 417 74 versus versus IN cord-015922-5wwy0m2k 417 75 - - HYPH cord-015922-5wwy0m2k 417 76 host host NN cord-015922-5wwy0m2k 417 77 disease disease NN cord-015922-5wwy0m2k 417 78 Posaconazole Posaconazole NNP cord-015922-5wwy0m2k 417 79 vs. vs. IN cord-015922-5wwy0m2k 417 80 fluconazole fluconazole NNP cord-015922-5wwy0m2k 417 81 or or CC cord-015922-5wwy0m2k 417 82 itraconazole itraconazole NNP cord-015922-5wwy0m2k 417 83 prophylaxis prophylaxis NN cord-015922-5wwy0m2k 417 84 in in IN cord-015922-5wwy0m2k 417 85 patients patient NNS cord-015922-5wwy0m2k 417 86 with with IN cord-015922-5wwy0m2k 417 87 neutropenia neutropenia NN cord-015922-5wwy0m2k 417 88 Prophylaxis Prophylaxis NNP cord-015922-5wwy0m2k 417 89 and and CC cord-015922-5wwy0m2k 417 90 aspergillosis aspergillosis NN cord-015922-5wwy0m2k 417 91 - - , cord-015922-5wwy0m2k 417 92 has have VBZ cord-015922-5wwy0m2k 417 93 the the DT cord-015922-5wwy0m2k 417 94 principle principle NN cord-015922-5wwy0m2k 417 95 been be VBN cord-015922-5wwy0m2k 417 96 proven prove VBN cord-015922-5wwy0m2k 417 97 ? ? . cord-015922-5wwy0m2k 418 1 Posaconazole Posaconazole NNP cord-015922-5wwy0m2k 418 2 as as IN cord-015922-5wwy0m2k 418 3 salvage salvage NN cord-015922-5wwy0m2k 418 4 therapy therapy NN cord-015922-5wwy0m2k 418 5 for for IN cord-015922-5wwy0m2k 419 1 zygomycosis zygomycosis NNP cord-015922-5wwy0m2k 419 2 Posaconazole Posaconazole NNP cord-015922-5wwy0m2k 419 3 is be VBZ cord-015922-5wwy0m2k 419 4 effective effective JJ cord-015922-5wwy0m2k 419 5 as as IN cord-015922-5wwy0m2k 419 6 salvage salvage NN cord-015922-5wwy0m2k 419 7 therapy therapy NN cord-015922-5wwy0m2k 419 8 in in IN cord-015922-5wwy0m2k 419 9 zygomycosis zygomycosis NNP cord-015922-5wwy0m2k 419 10 : : : cord-015922-5wwy0m2k 419 11 a a DT cord-015922-5wwy0m2k 419 12 retrospective retrospective JJ cord-015922-5wwy0m2k 419 13 summary summary NN cord-015922-5wwy0m2k 419 14 of of IN cord-015922-5wwy0m2k 419 15 91 91 CD cord-015922-5wwy0m2k 419 16 cases case NNS cord-015922-5wwy0m2k 419 17 Treatment treatment NN cord-015922-5wwy0m2k 419 18 of of IN cord-015922-5wwy0m2k 419 19 invasive invasive JJ cord-015922-5wwy0m2k 419 20 aspergillosis aspergillosis NN cord-015922-5wwy0m2k 419 21 with with IN cord-015922-5wwy0m2k 419 22 posaconazole posaconazole NNP cord-015922-5wwy0m2k 419 23 in in IN cord-015922-5wwy0m2k 419 24 patients patient NNS cord-015922-5wwy0m2k 419 25 who who WP cord-015922-5wwy0m2k 419 26 are be VBP cord-015922-5wwy0m2k 419 27 refractory refractory JJ cord-015922-5wwy0m2k 419 28 to to IN cord-015922-5wwy0m2k 419 29 or or CC cord-015922-5wwy0m2k 419 30 intolerant intolerant JJ cord-015922-5wwy0m2k 419 31 of of IN cord-015922-5wwy0m2k 419 32 conventional conventional JJ cord-015922-5wwy0m2k 419 33 therapy therapy NN cord-015922-5wwy0m2k 419 34 : : : cord-015922-5wwy0m2k 419 35 an an DT cord-015922-5wwy0m2k 419 36 externally externally RB cord-015922-5wwy0m2k 419 37 controlled control VBN cord-015922-5wwy0m2k 419 38 trial trial NN cord-015922-5wwy0m2k 419 39 We -PRON- PRP cord-015922-5wwy0m2k 419 40 would would MD cord-015922-5wwy0m2k 419 41 like like VB cord-015922-5wwy0m2k 419 42 to to TO cord-015922-5wwy0m2k 419 43 thank thank VB cord-015922-5wwy0m2k 419 44 Robert Robert NNP cord-015922-5wwy0m2k 419 45 H H NNP cord-015922-5wwy0m2k 419 46 Rubin Rubin NNP cord-015922-5wwy0m2k 419 47 , , , cord-015922-5wwy0m2k 419 48 M.D. M.D. NNP cord-015922-5wwy0m2k 419 49 for for IN cord-015922-5wwy0m2k 419 50 the the DT cord-015922-5wwy0m2k 419 51 many many JJ cord-015922-5wwy0m2k 419 52 years year NNS cord-015922-5wwy0m2k 419 53 of of IN cord-015922-5wwy0m2k 419 54 advice advice NN cord-015922-5wwy0m2k 419 55 and and CC cord-015922-5wwy0m2k 419 56 teaching teaching NN cord-015922-5wwy0m2k 419 57 , , , cord-015922-5wwy0m2k 419 58 and and CC cord-015922-5wwy0m2k 419 59 for for IN cord-015922-5wwy0m2k 419 60 critically critically RB cord-015922-5wwy0m2k 419 61 reviewing review VBG cord-015922-5wwy0m2k 419 62 this this DT cord-015922-5wwy0m2k 419 63 work work NN cord-015922-5wwy0m2k 419 64 . . .