id sid tid token lemma pos cord-009380-5uptbat3 1 1 key key JJ cord-009380-5uptbat3 1 2 : : : cord-009380-5uptbat3 1 3 cord-009380 cord-009380 NNP cord-009380-5uptbat3 1 4 - - HYPH cord-009380-5uptbat3 1 5 5uptbat3 5uptbat3 CD cord-009380-5uptbat3 1 6 authors author NNS cord-009380-5uptbat3 1 7 : : : cord-009380-5uptbat3 1 8 Evermann Evermann NNP cord-009380-5uptbat3 1 9 , , , cord-009380-5uptbat3 1 10 James James NNP cord-009380-5uptbat3 1 11 F. F. NNP cord-009380-5uptbat3 1 12 ; ; : cord-009380-5uptbat3 1 13 Eriks Eriks NNP cord-009380-5uptbat3 1 14 , , , cord-009380-5uptbat3 2 1 Inge Inge NNP cord-009380-5uptbat3 2 2 S. S. NNP cord-009380-5uptbat3 2 3 title title NN cord-009380-5uptbat3 2 4 : : : cord-009380-5uptbat3 2 5 Diagnostic diagnostic JJ cord-009380-5uptbat3 2 6 Medicine medicine NN cord-009380-5uptbat3 2 7 : : : cord-009380-5uptbat3 3 1 The the DT cord-009380-5uptbat3 3 2 Challenge Challenge NNP cord-009380-5uptbat3 3 3 of of IN cord-009380-5uptbat3 3 4 Differentiating differentiate VBG cord-009380-5uptbat3 3 5 Infection Infection NNP cord-009380-5uptbat3 3 6 from from IN cord-009380-5uptbat3 3 7 Disease Disease NNP cord-009380-5uptbat3 3 8 and and CC cord-009380-5uptbat3 3 9 Making make VBG cord-009380-5uptbat3 3 10 Sense sense NN cord-009380-5uptbat3 3 11 for for IN cord-009380-5uptbat3 3 12 the the DT cord-009380-5uptbat3 3 13 Veterinary Veterinary NNP cord-009380-5uptbat3 3 14 Clinician clinician NN cord-009380-5uptbat3 3 15 date date NN cord-009380-5uptbat3 3 16 : : : cord-009380-5uptbat3 3 17 2007 2007 CD cord-009380-5uptbat3 3 18 - - SYM cord-009380-5uptbat3 3 19 09 09 CD cord-009380-5uptbat3 3 20 - - HYPH cord-009380-5uptbat3 3 21 28 28 CD cord-009380-5uptbat3 3 22 journal journal NN cord-009380-5uptbat3 3 23 : : : cord-009380-5uptbat3 4 1 Adv Adv NNP cord-009380-5uptbat3 4 2 Vet Vet NNP cord-009380-5uptbat3 4 3 Med Med NNP cord-009380-5uptbat3 4 4 DOI doi NN cord-009380-5uptbat3 4 5 : : : cord-009380-5uptbat3 4 6 10.1016 10.1016 CD cord-009380-5uptbat3 4 7 / / SYM cord-009380-5uptbat3 4 8 s0065 s0065 NNP cord-009380-5uptbat3 4 9 - - HYPH cord-009380-5uptbat3 4 10 3519(99)80006 3519(99)80006 NNP cord-009380-5uptbat3 4 11 - - HYPH cord-009380-5uptbat3 4 12 8 8 CD cord-009380-5uptbat3 4 13 sha sha NN cord-009380-5uptbat3 4 14 : : : cord-009380-5uptbat3 5 1 648ed0aba3a6304926ca69e2f2d728fb3e5f4147 648ed0aba3a6304926ca69e2f2d728fb3e5f4147 CD cord-009380-5uptbat3 5 2 doc_id doc_id CD cord-009380-5uptbat3 5 3 : : : cord-009380-5uptbat3 5 4 9380 9380 CD cord-009380-5uptbat3 5 5 cord_uid cord_uid NNS cord-009380-5uptbat3 5 6 : : : cord-009380-5uptbat3 6 1 5uptbat3 5uptbat3 CD cord-009380-5uptbat3 6 2 nan nan NNP cord-009380-5uptbat3 6 3 Diagnostic Diagnostic NNP cord-009380-5uptbat3 6 4 medicine medicine NN cord-009380-5uptbat3 6 5 has have VBZ cord-009380-5uptbat3 6 6 taken take VBN cord-009380-5uptbat3 6 7 on on RP cord-009380-5uptbat3 6 8 a a DT cord-009380-5uptbat3 6 9 new new JJ cord-009380-5uptbat3 6 10 , , , cord-009380-5uptbat3 6 11 broader broad JJR cord-009380-5uptbat3 6 12 meaning meaning NN cord-009380-5uptbat3 6 13 in in IN cord-009380-5uptbat3 6 14 the the DT cord-009380-5uptbat3 6 15 1990s 1990 NNS cord-009380-5uptbat3 6 16 and and CC cord-009380-5uptbat3 6 17 reflects reflect VBZ cord-009380-5uptbat3 6 18 an an DT cord-009380-5uptbat3 6 19 expansion expansion NN cord-009380-5uptbat3 6 20 of of IN cord-009380-5uptbat3 6 21 clinical clinical JJ cord-009380-5uptbat3 6 22 investigation investigation NN cord-009380-5uptbat3 6 23 from from IN cord-009380-5uptbat3 6 24 the the DT cord-009380-5uptbat3 6 25 diagnosis diagnosis NN cord-009380-5uptbat3 6 26 of of IN cord-009380-5uptbat3 6 27 disease disease NN cord-009380-5uptbat3 6 28 to to TO cord-009380-5uptbat3 6 29 include include VB cord-009380-5uptbat3 6 30 detection detection NN cord-009380-5uptbat3 6 31 of of IN cord-009380-5uptbat3 6 32 infection infection NN cord-009380-5uptbat3 6 33 ( ( -LRB- cord-009380-5uptbat3 6 34 Evermann Evermann NNP cord-009380-5uptbat3 6 35 , , , cord-009380-5uptbat3 6 36 1998 1998 CD cord-009380-5uptbat3 6 37 ) ) -RRB- cord-009380-5uptbat3 6 38 . . . cord-009380-5uptbat3 7 1 This this DT cord-009380-5uptbat3 7 2 leads lead VBZ cord-009380-5uptbat3 7 3 to to IN cord-009380-5uptbat3 7 4 an an DT cord-009380-5uptbat3 7 5 entirely entirely RB cord-009380-5uptbat3 7 6 new new JJ cord-009380-5uptbat3 7 7 perspective perspective NN cord-009380-5uptbat3 7 8 on on IN cord-009380-5uptbat3 7 9 how how WRB cord-009380-5uptbat3 7 10 veterinary veterinary JJ cord-009380-5uptbat3 7 11 clinicians clinician NNS cord-009380-5uptbat3 7 12 and and CC cord-009380-5uptbat3 7 13 diagnosticians diagnostician NNS cord-009380-5uptbat3 7 14 view view VBP cord-009380-5uptbat3 7 15 laboratory laboratory NN cord-009380-5uptbat3 7 16 tests test NNS cord-009380-5uptbat3 7 17 and and CC cord-009380-5uptbat3 7 18 how how WRB cord-009380-5uptbat3 7 19 test test NN cord-009380-5uptbat3 7 20 results result NNS cord-009380-5uptbat3 7 21 are be VBP cord-009380-5uptbat3 7 22 interpreted interpret VBN cord-009380-5uptbat3 7 23 . . . cord-009380-5uptbat3 8 1 One one PRP cord-009380-5uptbat3 8 2 must must MD cord-009380-5uptbat3 8 3 consider consider VB cord-009380-5uptbat3 8 4 not not RB cord-009380-5uptbat3 8 5 only only RB cord-009380-5uptbat3 8 6 the the DT cord-009380-5uptbat3 8 7 specificity specificity NN cord-009380-5uptbat3 8 8 and and CC cord-009380-5uptbat3 8 9 sensitivity sensitivity NN cord-009380-5uptbat3 8 10 of of IN cord-009380-5uptbat3 8 11 the the DT cord-009380-5uptbat3 8 12 test test NN cord-009380-5uptbat3 8 13 , , , cord-009380-5uptbat3 8 14 but but CC cord-009380-5uptbat3 8 15 the the DT cord-009380-5uptbat3 8 16 predictive predictive JJ cord-009380-5uptbat3 8 17 value value NN cord-009380-5uptbat3 8 18 of of IN cord-009380-5uptbat3 8 19 the the DT cord-009380-5uptbat3 8 20 test test NN cord-009380-5uptbat3 8 21 , , , cord-009380-5uptbat3 8 22 which which WDT cord-009380-5uptbat3 8 23 relates relate VBZ cord-009380-5uptbat3 8 24 directly directly RB cord-009380-5uptbat3 8 25 to to IN cord-009380-5uptbat3 8 26 the the DT cord-009380-5uptbat3 8 27 clinical clinical JJ cord-009380-5uptbat3 8 28 utility utility NN cord-009380-5uptbat3 8 29 of of IN cord-009380-5uptbat3 8 30 the the DT cord-009380-5uptbat3 8 31 result result NN cord-009380-5uptbat3 8 32 ( ( -LRB- cord-009380-5uptbat3 8 33 Jacobson Jacobson NNP cord-009380-5uptbat3 8 34 , , , cord-009380-5uptbat3 8 35 1997 1997 CD cord-009380-5uptbat3 8 36 ) ) -RRB- cord-009380-5uptbat3 8 37 . . . cord-009380-5uptbat3 9 1 The the DT cord-009380-5uptbat3 9 2 definitive definitive JJ cord-009380-5uptbat3 9 3 diagnosis diagnosis NN cord-009380-5uptbat3 9 4 of of IN cord-009380-5uptbat3 9 5 infectious infectious JJ cord-009380-5uptbat3 9 6 diseases disease NNS cord-009380-5uptbat3 9 7 relies rely VBZ cord-009380-5uptbat3 9 8 on on IN cord-009380-5uptbat3 9 9 a a DT cord-009380-5uptbat3 9 10 combination combination NN cord-009380-5uptbat3 9 11 of of IN cord-009380-5uptbat3 9 12 clinical clinical JJ cord-009380-5uptbat3 9 13 symptoms symptom NNS cord-009380-5uptbat3 9 14 , , , cord-009380-5uptbat3 9 15 history history NN cord-009380-5uptbat3 9 16 , , , cord-009380-5uptbat3 9 17 and and CC cord-009380-5uptbat3 9 18 laboratory laboratory NN cord-009380-5uptbat3 9 19 analyses analysis NNS cord-009380-5uptbat3 9 20 of of IN cord-009380-5uptbat3 9 21 ante ante NN cord-009380-5uptbat3 9 22 - - HYPH cord-009380-5uptbat3 9 23 mortem mortem NN cord-009380-5uptbat3 9 24 and/or and/or CC cord-009380-5uptbat3 9 25 postmortem postmortem JJ cord-009380-5uptbat3 9 26 specimens specimen NNS cord-009380-5uptbat3 9 27 ( ( -LRB- cord-009380-5uptbat3 9 28 Evermann Evermann NNP cord-009380-5uptbat3 9 29 , , , cord-009380-5uptbat3 9 30 1998 1998 CD cord-009380-5uptbat3 9 31 ) ) -RRB- cord-009380-5uptbat3 9 32 . . . cord-009380-5uptbat3 10 1 Disease disease NN cord-009380-5uptbat3 10 2 diagnosis diagnosis NN cord-009380-5uptbat3 10 3 has have VBZ cord-009380-5uptbat3 10 4 customarily customarily RB cord-009380-5uptbat3 10 5 used use VBN cord-009380-5uptbat3 10 6 diagnostic diagnostic JJ cord-009380-5uptbat3 10 7 assays assay NNS cord-009380-5uptbat3 10 8 for for IN cord-009380-5uptbat3 10 9 early early JJ cord-009380-5uptbat3 10 10 recognition recognition NN cord-009380-5uptbat3 10 11 of of IN cord-009380-5uptbat3 10 12 disease disease NN cord-009380-5uptbat3 10 13 and and CC cord-009380-5uptbat3 10 14 rapid rapid JJ cord-009380-5uptbat3 10 15 implementation implementation NN cord-009380-5uptbat3 10 16 of of IN cord-009380-5uptbat3 10 17 therapy therapy NN cord-009380-5uptbat3 10 18 in in IN cord-009380-5uptbat3 10 19 an an DT cord-009380-5uptbat3 10 20 individual individual JJ cord-009380-5uptbat3 10 21 animal animal NN cord-009380-5uptbat3 10 22 basis basis NN cord-009380-5uptbat3 10 23 , , , cord-009380-5uptbat3 10 24 and and CC cord-009380-5uptbat3 10 25 when when WRB cord-009380-5uptbat3 10 26 appropriate appropriate JJ cord-009380-5uptbat3 10 27 use use NN cord-009380-5uptbat3 10 28 of of IN cord-009380-5uptbat3 10 29 corrective corrective JJ cord-009380-5uptbat3 10 30 management management NN cord-009380-5uptbat3 10 31 ( ( -LRB- cord-009380-5uptbat3 10 32 segregation segregation NN cord-009380-5uptbat3 10 33 , , , cord-009380-5uptbat3 10 34 culling culling NN cord-009380-5uptbat3 10 35 , , , cord-009380-5uptbat3 10 36 vaccination vaccination NN cord-009380-5uptbat3 10 37 , , , cord-009380-5uptbat3 10 38 etc etc FW cord-009380-5uptbat3 10 39 . . . cord-009380-5uptbat3 10 40 ) ) -RRB- cord-009380-5uptbat3 11 1 on on IN cord-009380-5uptbat3 11 2 a a DT cord-009380-5uptbat3 11 3 population population NN cord-009380-5uptbat3 11 4 basis basis NN cord-009380-5uptbat3 11 5 . . . cord-009380-5uptbat3 12 1 The the DT cord-009380-5uptbat3 12 2 detection detection NN cord-009380-5uptbat3 12 3 of of IN cord-009380-5uptbat3 12 4 infection infection NN cord-009380-5uptbat3 12 5 during during IN cord-009380-5uptbat3 12 6 preclinical preclinical JJ cord-009380-5uptbat3 12 7 stages stage NNS cord-009380-5uptbat3 12 8 has have VBZ cord-009380-5uptbat3 12 9 become become VBN cord-009380-5uptbat3 12 10 more more RBR cord-009380-5uptbat3 12 11 important important JJ cord-009380-5uptbat3 12 12 as as IN cord-009380-5uptbat3 12 13 one one PRP cord-009380-5uptbat3 12 14 considers consider VBZ cord-009380-5uptbat3 12 15 the the DT cord-009380-5uptbat3 12 16 consequence consequence NN cord-009380-5uptbat3 12 17 of of IN cord-009380-5uptbat3 12 18 long long JJ cord-009380-5uptbat3 12 19 - - HYPH cord-009380-5uptbat3 12 20 term term NN cord-009380-5uptbat3 12 21 infections infection NNS cord-009380-5uptbat3 12 22 that that WDT cord-009380-5uptbat3 12 23 have have VBP cord-009380-5uptbat3 12 24 prolonged prolong VBN cord-009380-5uptbat3 12 25 incubation incubation NN cord-009380-5uptbat3 12 26 periods period NNS cord-009380-5uptbat3 12 27 and and CC cord-009380-5uptbat3 12 28 inapparent inapparent JJ cord-009380-5uptbat3 12 29 transmission transmission NN cord-009380-5uptbat3 12 30 to to IN cord-009380-5uptbat3 12 31 susceptible susceptible JJ cord-009380-5uptbat3 12 32 animals animal NNS cord-009380-5uptbat3 12 33 in in IN cord-009380-5uptbat3 12 34 the the DT cord-009380-5uptbat3 12 35 population population NN cord-009380-5uptbat3 12 36 . . . cord-009380-5uptbat3 13 1 This this DT cord-009380-5uptbat3 13 2 includes include VBZ cord-009380-5uptbat3 13 3 lifethreatening lifethreatene VBG cord-009380-5uptbat3 13 4 diseases disease NNS cord-009380-5uptbat3 13 5 , , , cord-009380-5uptbat3 13 6 such such JJ cord-009380-5uptbat3 13 7 as as IN cord-009380-5uptbat3 13 8 feline feline JJ cord-009380-5uptbat3 13 9 infectious infectious JJ cord-009380-5uptbat3 13 10 peritonitis peritonitis NN cord-009380-5uptbat3 13 11 ( ( -LRB- cord-009380-5uptbat3 13 12 FIP FIP NNP cord-009380-5uptbat3 13 13 ) ) -RRB- cord-009380-5uptbat3 13 14 , , , cord-009380-5uptbat3 13 15 rickettsial rickettsial JJ cord-009380-5uptbat3 13 16 and and CC cord-009380-5uptbat3 13 17 ehrlichial ehrlichial JJ cord-009380-5uptbat3 13 18 diseases disease NNS cord-009380-5uptbat3 13 19 and and CC cord-009380-5uptbat3 13 20 canine canine JJ cord-009380-5uptbat3 13 21 herpesvirus herpesvirus NN cord-009380-5uptbat3 13 22 ( ( -LRB- cord-009380-5uptbat3 13 23 CHV CHV NNP cord-009380-5uptbat3 13 24 ) ) -RRB- cord-009380-5uptbat3 13 25 infections infection NNS cord-009380-5uptbat3 13 26 . . . cord-009380-5uptbat3 14 1 Of of IN cord-009380-5uptbat3 14 2 equal equal JJ cord-009380-5uptbat3 14 3 , , , cord-009380-5uptbat3 14 4 if if IN cord-009380-5uptbat3 14 5 not not RB cord-009380-5uptbat3 14 6 more more RBR cord-009380-5uptbat3 14 7 so so RB cord-009380-5uptbat3 14 8 , , , cord-009380-5uptbat3 14 9 importance importance NN cord-009380-5uptbat3 14 10 for for IN cord-009380-5uptbat3 14 11 the the DT cord-009380-5uptbat3 14 12 early early JJ cord-009380-5uptbat3 14 13 detection detection NN cord-009380-5uptbat3 14 14 of of IN cord-009380-5uptbat3 14 15 infection infection NN cord-009380-5uptbat3 14 16 has have VBZ cord-009380-5uptbat3 14 17 been be VBN cord-009380-5uptbat3 14 18 the the DT cord-009380-5uptbat3 14 19 increased increase VBN cord-009380-5uptbat3 14 20 recognition recognition NN cord-009380-5uptbat3 14 21 of of IN cord-009380-5uptbat3 14 22 zoonotic zoonotic JJ cord-009380-5uptbat3 14 23 infections infection NNS cord-009380-5uptbat3 14 24 , , , cord-009380-5uptbat3 14 25 such such JJ cord-009380-5uptbat3 14 26 as as IN cord-009380-5uptbat3 14 27 rabies rabies NN cord-009380-5uptbat3 14 28 virus virus NN cord-009380-5uptbat3 14 29 , , , cord-009380-5uptbat3 14 30 Salmonella salmonella NN cord-009380-5uptbat3 14 31 typhimurium typhimurium NN cord-009380-5uptbat3 14 32 DT104 DT104 NNP cord-009380-5uptbat3 14 33 , , , cord-009380-5uptbat3 14 34 and and CC cord-009380-5uptbat3 14 35 Escherichia Escherichia NNP cord-009380-5uptbat3 14 36 coli coli NNS cord-009380-5uptbat3 14 37 O157 O157 NNP cord-009380-5uptbat3 14 38 : : : cord-009380-5uptbat3 15 1 H7 H7 NNP cord-009380-5uptbat3 15 2 ( ( -LRB- cord-009380-5uptbat3 15 3 Evans Evans NNP cord-009380-5uptbat3 15 4 and and CC cord-009380-5uptbat3 15 5 Davies Davies NNP cord-009380-5uptbat3 15 6 , , , cord-009380-5uptbat3 15 7 1996 1996 CD cord-009380-5uptbat3 15 8 ; ; : cord-009380-5uptbat3 15 9 Slutsker Slutsker NNP cord-009380-5uptbat3 15 10 et et NNP cord-009380-5uptbat3 15 11 al al NNP cord-009380-5uptbat3 15 12 . . NNP cord-009380-5uptbat3 15 13 , , , cord-009380-5uptbat3 15 14 1997 1997 CD cord-009380-5uptbat3 15 15 ; ; : cord-009380-5uptbat3 15 16 Smith Smith NNP cord-009380-5uptbat3 15 17 , , , cord-009380-5uptbat3 15 18 1996 1996 CD cord-009380-5uptbat3 15 19 ) ) -RRB- cord-009380-5uptbat3 15 20 . . . cord-009380-5uptbat3 16 1 Together together RB cord-009380-5uptbat3 16 2 with with IN cord-009380-5uptbat3 16 3 the the DT cord-009380-5uptbat3 16 4 necessity necessity NN cord-009380-5uptbat3 16 5 to to TO cord-009380-5uptbat3 16 6 detect detect VB cord-009380-5uptbat3 16 7 infections infection NNS cord-009380-5uptbat3 16 8 earlier early RBR cord-009380-5uptbat3 16 9 during during IN cord-009380-5uptbat3 16 10 the the DT cord-009380-5uptbat3 16 11 preclinical preclinical JJ cord-009380-5uptbat3 16 12 stages stage NNS cord-009380-5uptbat3 16 13 , , , cord-009380-5uptbat3 16 14 there there EX cord-009380-5uptbat3 16 15 has have VBZ cord-009380-5uptbat3 16 16 been be VBN cord-009380-5uptbat3 16 17 a a DT cord-009380-5uptbat3 16 18 remarkable remarkable JJ cord-009380-5uptbat3 16 19 expansion expansion NN cord-009380-5uptbat3 16 20 in in IN cord-009380-5uptbat3 16 21 the the DT cord-009380-5uptbat3 16 22 availability availability NN cord-009380-5uptbat3 16 23 of of IN cord-009380-5uptbat3 16 24 assays assay NNS cord-009380-5uptbat3 16 25 that that WDT cord-009380-5uptbat3 16 26 can can MD cord-009380-5uptbat3 16 27 detect detect VB cord-009380-5uptbat3 16 28 infectious infectious JJ cord-009380-5uptbat3 16 29 microorganisms microorganism NNS cord-009380-5uptbat3 16 30 in in IN cord-009380-5uptbat3 16 31 low low JJ cord-009380-5uptbat3 16 32 quantity quantity NN cord-009380-5uptbat3 16 33 . . . cord-009380-5uptbat3 17 1 This this DT cord-009380-5uptbat3 17 2 increased increase VBN cord-009380-5uptbat3 17 3 sensitivity sensitivity NN cord-009380-5uptbat3 17 4 has have VBZ cord-009380-5uptbat3 17 5 been be VBN cord-009380-5uptbat3 17 6 primarily primarily RB cord-009380-5uptbat3 17 7 through through IN cord-009380-5uptbat3 17 8 the the DT cord-009380-5uptbat3 17 9 detection detection NN cord-009380-5uptbat3 17 10 of of IN cord-009380-5uptbat3 17 11 nucleic nucleic JJ cord-009380-5uptbat3 17 12 acid acid NN cord-009380-5uptbat3 17 13 sequences sequence NNS cord-009380-5uptbat3 17 14 after after IN cord-009380-5uptbat3 17 15 amplification amplification NN cord-009380-5uptbat3 17 16 by by IN cord-009380-5uptbat3 17 17 polymerase polymerase NN cord-009380-5uptbat3 17 18 chain chain NN cord-009380-5uptbat3 17 19 reaction reaction NN cord-009380-5uptbat3 17 20 ( ( -LRB- cord-009380-5uptbat3 17 21 PCR PCR NNP cord-009380-5uptbat3 17 22 , , , cord-009380-5uptbat3 17 23 Relman Relman NNP cord-009380-5uptbat3 17 24 and and CC cord-009380-5uptbat3 17 25 Persing Persing NNP cord-009380-5uptbat3 17 26 , , , cord-009380-5uptbat3 17 27 1997 1997 CD cord-009380-5uptbat3 17 28 ) ) -RRB- cord-009380-5uptbat3 17 29 . . . cord-009380-5uptbat3 18 1 PCR PCR NNP cord-009380-5uptbat3 18 2 can can MD cord-009380-5uptbat3 18 3 allow allow VB cord-009380-5uptbat3 18 4 not not RB cord-009380-5uptbat3 18 5 only only RB cord-009380-5uptbat3 18 6 early early JJ cord-009380-5uptbat3 18 7 detection detection NN cord-009380-5uptbat3 18 8 of of IN cord-009380-5uptbat3 18 9 infection infection NN cord-009380-5uptbat3 18 10 , , , cord-009380-5uptbat3 18 11 but but CC cord-009380-5uptbat3 18 12 rapid rapid JJ cord-009380-5uptbat3 18 13 speciation speciation NN cord-009380-5uptbat3 18 14 of of IN cord-009380-5uptbat3 18 15 organisms organism NNS cord-009380-5uptbat3 18 16 as as RB cord-009380-5uptbat3 18 17 well well RB cord-009380-5uptbat3 18 18 as as IN cord-009380-5uptbat3 18 19 strain strain NN cord-009380-5uptbat3 18 20 typing typing NN cord-009380-5uptbat3 18 21 for for IN cord-009380-5uptbat3 18 22 epidemiologic epidemiologic JJ cord-009380-5uptbat3 18 23 analyses analysis NNS cord-009380-5uptbat3 18 24 ( ( -LRB- cord-009380-5uptbat3 18 25 Fredricks Fredricks NNP cord-009380-5uptbat3 18 26 and and CC cord-009380-5uptbat3 18 27 Relman Relman NNP cord-009380-5uptbat3 18 28 , , , cord-009380-5uptbat3 18 29 1996 1996 CD cord-009380-5uptbat3 18 30 ; ; : cord-009380-5uptbat3 18 31 McDade McDade NNP cord-009380-5uptbat3 18 32 and and CC cord-009380-5uptbat3 18 33 Anderson Anderson NNP cord-009380-5uptbat3 18 34 , , , cord-009380-5uptbat3 18 35 1996 1996 CD cord-009380-5uptbat3 18 36 ) ) -RRB- cord-009380-5uptbat3 18 37 . . . cord-009380-5uptbat3 19 1 The the DT cord-009380-5uptbat3 19 2 assessment assessment NN cord-009380-5uptbat3 19 3 of of IN cord-009380-5uptbat3 19 4 preclinical preclinical JJ cord-009380-5uptbat3 19 5 infections infection NNS cord-009380-5uptbat3 19 6 allows allow VBZ cord-009380-5uptbat3 19 7 the the DT cord-009380-5uptbat3 19 8 veterinarian veterinarian NN cord-009380-5uptbat3 19 9 the the DT cord-009380-5uptbat3 19 10 opportunity opportunity NN cord-009380-5uptbat3 19 11 to to TO cord-009380-5uptbat3 19 12 determine determine VB cord-009380-5uptbat3 19 13 the the DT cord-009380-5uptbat3 19 14 relative relative JJ cord-009380-5uptbat3 19 15 risk risk NN cord-009380-5uptbat3 19 16 of of IN cord-009380-5uptbat3 19 17 disease disease NN cord-009380-5uptbat3 19 18 occurring occur VBG cord-009380-5uptbat3 19 19 , , , cord-009380-5uptbat3 19 20 and and CC cord-009380-5uptbat3 19 21 to to TO cord-009380-5uptbat3 19 22 take take VB cord-009380-5uptbat3 19 23 preventive preventive JJ cord-009380-5uptbat3 19 24 steps step NNS cord-009380-5uptbat3 19 25 to to TO cord-009380-5uptbat3 19 26 reduce reduce VB cord-009380-5uptbat3 19 27 or or CC cord-009380-5uptbat3 19 28 eliminate eliminate VB cord-009380-5uptbat3 19 29 the the DT cord-009380-5uptbat3 19 30 risks risk NNS cord-009380-5uptbat3 19 31 depending depend VBG cord-009380-5uptbat3 19 32 on on IN cord-009380-5uptbat3 19 33 the the DT cord-009380-5uptbat3 19 34 consequences consequence NNS cord-009380-5uptbat3 19 35 of of IN cord-009380-5uptbat3 19 36 the the DT cord-009380-5uptbat3 19 37 disease disease NN cord-009380-5uptbat3 19 38 in in IN cord-009380-5uptbat3 19 39 the the DT cord-009380-5uptbat3 19 40 animal animal NN cord-009380-5uptbat3 19 41 and/or and/or CC cord-009380-5uptbat3 19 42 human human JJ cord-009380-5uptbat3 19 43 ( ( -LRB- cord-009380-5uptbat3 19 44 if if IN cord-009380-5uptbat3 19 45 zoonotic zoonotic JJ cord-009380-5uptbat3 19 46 ) ) -RRB- cord-009380-5uptbat3 19 47 population population NN cord-009380-5uptbat3 19 48 . . . cord-009380-5uptbat3 20 1 This this DT cord-009380-5uptbat3 20 2 chapter chapter NN cord-009380-5uptbat3 20 3 focuses focus VBZ cord-009380-5uptbat3 20 4 on on IN cord-009380-5uptbat3 20 5 one one CD cord-009380-5uptbat3 20 6 main main JJ cord-009380-5uptbat3 20 7 issue issue NN cord-009380-5uptbat3 20 8 , , , cord-009380-5uptbat3 20 9 and and CC cord-009380-5uptbat3 20 10 that that DT cord-009380-5uptbat3 20 11 is be VBZ cord-009380-5uptbat3 20 12 differentiating differentiate VBG cord-009380-5uptbat3 20 13 the the DT cord-009380-5uptbat3 20 14 detection detection NN cord-009380-5uptbat3 20 15 of of IN cord-009380-5uptbat3 20 16 infection infection NN cord-009380-5uptbat3 20 17 from from IN cord-009380-5uptbat3 20 18 diagnosis diagnosis NN cord-009380-5uptbat3 20 19 of of IN cord-009380-5uptbat3 20 20 disease disease NN cord-009380-5uptbat3 20 21 . . . cord-009380-5uptbat3 21 1 In in IN cord-009380-5uptbat3 21 2 the the DT cord-009380-5uptbat3 21 3 course course NN cord-009380-5uptbat3 21 4 of of IN cord-009380-5uptbat3 21 5 differentiating differentiate VBG cord-009380-5uptbat3 21 6 infection infection NN cord-009380-5uptbat3 21 7 from from IN cord-009380-5uptbat3 21 8 disease disease NN cord-009380-5uptbat3 21 9 three three CD cord-009380-5uptbat3 21 10 questions question NNS cord-009380-5uptbat3 21 11 will will MD cord-009380-5uptbat3 21 12 be be VB cord-009380-5uptbat3 21 13 addressed address VBN cord-009380-5uptbat3 21 14 : : : cord-009380-5uptbat3 21 15 ( ( -LRB- cord-009380-5uptbat3 21 16 1 1 LS cord-009380-5uptbat3 21 17 ) ) -RRB- cord-009380-5uptbat3 22 1 How how WRB cord-009380-5uptbat3 22 2 early early RB cord-009380-5uptbat3 22 3 do do VBP cord-009380-5uptbat3 22 4 we -PRON- PRP cord-009380-5uptbat3 22 5 want want VB cord-009380-5uptbat3 22 6 to to TO cord-009380-5uptbat3 22 7 detect detect VB cord-009380-5uptbat3 22 8 infection infection NN cord-009380-5uptbat3 22 9 ? ? . cord-009380-5uptbat3 23 1 ( ( -LRB- cord-009380-5uptbat3 23 2 2 2 LS cord-009380-5uptbat3 23 3 ) ) -RRB- cord-009380-5uptbat3 24 1 What what WP cord-009380-5uptbat3 24 2 are be VBP cord-009380-5uptbat3 24 3 the the DT cord-009380-5uptbat3 24 4 consequences consequence NNS cord-009380-5uptbat3 24 5 of of IN cord-009380-5uptbat3 24 6 the the DT cord-009380-5uptbat3 24 7 results result NNS cord-009380-5uptbat3 24 8 ? ? . cord-009380-5uptbat3 25 1 ( ( -LRB- cord-009380-5uptbat3 25 2 3 3 LS cord-009380-5uptbat3 25 3 ) ) -RRB- cord-009380-5uptbat3 25 4 Where where WRB cord-009380-5uptbat3 25 5 are be VBP cord-009380-5uptbat3 25 6 we -PRON- PRP cord-009380-5uptbat3 25 7 heading head VBG cord-009380-5uptbat3 25 8 with with IN cord-009380-5uptbat3 25 9 veterinary veterinary JJ cord-009380-5uptbat3 25 10 diagnostics diagnostic NNS cord-009380-5uptbat3 25 11 ? ? . cord-009380-5uptbat3 26 1 Historically historically RB cord-009380-5uptbat3 26 2 , , , cord-009380-5uptbat3 26 3 the the DT cord-009380-5uptbat3 26 4 primary primary JJ cord-009380-5uptbat3 26 5 aim aim NN cord-009380-5uptbat3 26 6 of of IN cord-009380-5uptbat3 26 7 the the DT cord-009380-5uptbat3 26 8 diagnostic diagnostic JJ cord-009380-5uptbat3 26 9 laboratory laboratory NN cord-009380-5uptbat3 26 10 was be VBD cord-009380-5uptbat3 26 11 to to TO cord-009380-5uptbat3 26 12 assist assist VB cord-009380-5uptbat3 26 13 the the DT cord-009380-5uptbat3 26 14 veterinarian veterinarian NN cord-009380-5uptbat3 26 15 in in IN cord-009380-5uptbat3 26 16 the the DT cord-009380-5uptbat3 26 17 diagnosis diagnosis NN cord-009380-5uptbat3 26 18 of of IN cord-009380-5uptbat3 26 19 disease disease NN cord-009380-5uptbat3 26 20 . . . cord-009380-5uptbat3 27 1 This this DT cord-009380-5uptbat3 27 2 is be VBZ cord-009380-5uptbat3 27 3 presented present VBN cord-009380-5uptbat3 27 4 in in IN cord-009380-5uptbat3 27 5 Fig Fig NNP cord-009380-5uptbat3 27 6 . . . cord-009380-5uptbat3 28 1 1 1 LS cord-009380-5uptbat3 28 2 . . . cord-009380-5uptbat3 29 1 This this DT cord-009380-5uptbat3 29 2 type type NN cord-009380-5uptbat3 29 3 of of IN cord-009380-5uptbat3 29 4 approach approach NN cord-009380-5uptbat3 29 5 initially initially RB cord-009380-5uptbat3 29 6 ignored ignore VBD cord-009380-5uptbat3 29 7 the the DT cord-009380-5uptbat3 29 8 origin origin NN cord-009380-5uptbat3 29 9 of of IN cord-009380-5uptbat3 29 10 the the DT cord-009380-5uptbat3 29 11 causative causative JJ cord-009380-5uptbat3 29 12 microorganisms microorganism NNS cord-009380-5uptbat3 29 13 and and CC cord-009380-5uptbat3 29 14 focused focus VBD cord-009380-5uptbat3 29 15 on on IN cord-009380-5uptbat3 29 16 the the DT cord-009380-5uptbat3 29 17 accurate accurate JJ cord-009380-5uptbat3 29 18 diagnosis diagnosis NN cord-009380-5uptbat3 29 19 of of IN cord-009380-5uptbat3 29 20 the the DT cord-009380-5uptbat3 29 21 disease disease NN cord-009380-5uptbat3 29 22 agent agent NN cord-009380-5uptbat3 29 23 . . . cord-009380-5uptbat3 30 1 An an DT cord-009380-5uptbat3 30 2 example example NN cord-009380-5uptbat3 30 3 of of IN cord-009380-5uptbat3 30 4 this this DT cord-009380-5uptbat3 30 5 type type NN cord-009380-5uptbat3 30 6 of of IN cord-009380-5uptbat3 30 7 approach approach NN cord-009380-5uptbat3 30 8 was be VBD cord-009380-5uptbat3 30 9 the the DT cord-009380-5uptbat3 30 10 testing testing NN cord-009380-5uptbat3 30 11 of of IN cord-009380-5uptbat3 30 12 cats cat NNS cord-009380-5uptbat3 30 13 that that WDT cord-009380-5uptbat3 30 14 were be VBD cord-009380-5uptbat3 30 15 clinically clinically RB cord-009380-5uptbat3 30 16 ill ill JJ cord-009380-5uptbat3 30 17 for for IN cord-009380-5uptbat3 30 18 feline feline JJ cord-009380-5uptbat3 30 19 leukemia leukemia NN cord-009380-5uptbat3 30 20 virus virus NN cord-009380-5uptbat3 30 21 ( ( -LRB- cord-009380-5uptbat3 30 22 FeLV FeLV NNP cord-009380-5uptbat3 30 23 ) ) -RRB- cord-009380-5uptbat3 30 24 . . . cord-009380-5uptbat3 31 1 If if IN cord-009380-5uptbat3 31 2 tested test VBN cord-009380-5uptbat3 31 3 positive positive JJ cord-009380-5uptbat3 31 4 , , , cord-009380-5uptbat3 31 5 they -PRON- PRP cord-009380-5uptbat3 31 6 were be VBD cord-009380-5uptbat3 31 7 segregated segregate VBN cord-009380-5uptbat3 31 8 or or CC cord-009380-5uptbat3 31 9 euthanized euthanize VBN cord-009380-5uptbat3 31 10 . . . cord-009380-5uptbat3 32 1 Further further JJ cord-009380-5uptbat3 32 2 examples example NNS cord-009380-5uptbat3 32 3 include include VBP cord-009380-5uptbat3 32 4 FIP FIP NNP cord-009380-5uptbat3 32 5 , , , cord-009380-5uptbat3 32 6 CHV CHV NNP cord-009380-5uptbat3 32 7 , , , cord-009380-5uptbat3 32 8 Johne Johne NNP cord-009380-5uptbat3 32 9 's 's POS cord-009380-5uptbat3 32 10 disease disease NN cord-009380-5uptbat3 32 11 ( ( -LRB- cord-009380-5uptbat3 32 12 Mycobacterium Mycobacterium NNP cord-009380-5uptbat3 32 13 paratuberculosis paratuberculosis NN cord-009380-5uptbat3 32 14 ) ) -RRB- cord-009380-5uptbat3 32 15 , , , cord-009380-5uptbat3 32 16 and and CC cord-009380-5uptbat3 32 17 the the DT cord-009380-5uptbat3 32 18 mucosal mucosal JJ cord-009380-5uptbat3 32 19 disease disease NN cord-009380-5uptbat3 32 20 form form NN cord-009380-5uptbat3 32 21 of of IN cord-009380-5uptbat3 32 22 bovine bovine JJ cord-009380-5uptbat3 32 23 viral viral JJ cord-009380-5uptbat3 32 24 diarrhea diarrhea NN cord-009380-5uptbat3 32 25 ( ( -LRB- cord-009380-5uptbat3 32 26 BVD BVD NNP cord-009380-5uptbat3 32 27 ) ) -RRB- cord-009380-5uptbat3 32 28 virus virus NN cord-009380-5uptbat3 32 29 . . . cord-009380-5uptbat3 33 1 Expanded expand VBN cord-009380-5uptbat3 33 2 use use NN cord-009380-5uptbat3 33 3 of of IN cord-009380-5uptbat3 33 4 diagnostic diagnostic JJ cord-009380-5uptbat3 33 5 results result NNS cord-009380-5uptbat3 33 6 by by IN cord-009380-5uptbat3 33 7 the the DT cord-009380-5uptbat3 33 8 veterinarian veterinarian NN cord-009380-5uptbat3 33 9 and and CC cord-009380-5uptbat3 33 10 client client NN cord-009380-5uptbat3 33 11 allowed allow VBD cord-009380-5uptbat3 33 12 for for IN cord-009380-5uptbat3 33 13 some some DT cord-009380-5uptbat3 33 14 corrective corrective JJ cord-009380-5uptbat3 33 15 management management NN cord-009380-5uptbat3 33 16 steps step NNS cord-009380-5uptbat3 33 17 to to TO cord-009380-5uptbat3 33 18 be be VB cord-009380-5uptbat3 33 19 taken take VBN cord-009380-5uptbat3 33 20 . . . cord-009380-5uptbat3 34 1 These these DT cord-009380-5uptbat3 34 2 included include VBD cord-009380-5uptbat3 34 3 the the DT cord-009380-5uptbat3 34 4 use use NN cord-009380-5uptbat3 34 5 of of IN cord-009380-5uptbat3 34 6 vaccination vaccination NN cord-009380-5uptbat3 34 7 when when WRB cord-009380-5uptbat3 34 8 available available JJ cord-009380-5uptbat3 34 9 or or CC cord-009380-5uptbat3 34 10 segregation segregation NN cord-009380-5uptbat3 34 11 and and CC cord-009380-5uptbat3 34 12 culling cull VBG cord-009380-5uptbat3 34 13 to to TO cord-009380-5uptbat3 34 14 reduce reduce VB cord-009380-5uptbat3 34 15 the the DT cord-009380-5uptbat3 34 16 source source NN cord-009380-5uptbat3 34 17 of of IN cord-009380-5uptbat3 34 18 the the DT cord-009380-5uptbat3 34 19 infection infection NN cord-009380-5uptbat3 34 20 in in IN cord-009380-5uptbat3 34 21 the the DT cord-009380-5uptbat3 34 22 population population NN cord-009380-5uptbat3 34 23 . . . cord-009380-5uptbat3 35 1 Based base VBN cord-009380-5uptbat3 35 2 on on IN cord-009380-5uptbat3 35 3 this this DT cord-009380-5uptbat3 35 4 latter latter JJ cord-009380-5uptbat3 35 5 principle principle NN cord-009380-5uptbat3 35 6 , , , cord-009380-5uptbat3 35 7 the the DT cord-009380-5uptbat3 35 8 reduction reduction NN cord-009380-5uptbat3 35 9 of of IN cord-009380-5uptbat3 35 10 the the DT cord-009380-5uptbat3 35 11 source source NN cord-009380-5uptbat3 35 12 of of IN cord-009380-5uptbat3 35 13 the the DT cord-009380-5uptbat3 35 14 infection infection NN cord-009380-5uptbat3 35 15 , , , cord-009380-5uptbat3 35 16 a a DT cord-009380-5uptbat3 35 17 different different JJ cord-009380-5uptbat3 35 18 approach approach NN cord-009380-5uptbat3 35 19 has have VBZ cord-009380-5uptbat3 35 20 been be VBN cord-009380-5uptbat3 35 21 taken take VBN cord-009380-5uptbat3 35 22 . . . cord-009380-5uptbat3 36 1 One one CD cord-009380-5uptbat3 36 2 may may MD cord-009380-5uptbat3 36 3 consider consider VB cord-009380-5uptbat3 36 4 this this DT cord-009380-5uptbat3 36 5 an an DT cord-009380-5uptbat3 36 6 epidemiologic epidemiologic JJ cord-009380-5uptbat3 36 7 view view NN cord-009380-5uptbat3 36 8 of of IN cord-009380-5uptbat3 36 9 the the DT cord-009380-5uptbat3 36 10 disease disease NN cord-009380-5uptbat3 36 11 process process NN cord-009380-5uptbat3 36 12 ( ( -LRB- cord-009380-5uptbat3 36 13 Susser Susser NNP cord-009380-5uptbat3 36 14 and and CC cord-009380-5uptbat3 36 15 Susser Susser NNP cord-009380-5uptbat3 36 16 , , , cord-009380-5uptbat3 36 17 1996a 1996a CD cord-009380-5uptbat3 36 18 ) ) -RRB- cord-009380-5uptbat3 36 19 . . . cord-009380-5uptbat3 37 1 With with IN cord-009380-5uptbat3 37 2 a a DT cord-009380-5uptbat3 37 3 combination combination NN cord-009380-5uptbat3 37 4 of of IN cord-009380-5uptbat3 37 5 more more RBR cord-009380-5uptbat3 37 6 sensitive sensitive JJ cord-009380-5uptbat3 37 7 diagnostic diagnostic JJ cord-009380-5uptbat3 37 8 assays assay NNS cord-009380-5uptbat3 37 9 , , , cord-009380-5uptbat3 37 10 the the DT cord-009380-5uptbat3 37 11 veterinarian veterinarian NN cord-009380-5uptbat3 37 12 's 's POS cord-009380-5uptbat3 37 13 concern concern NN cord-009380-5uptbat3 37 14 to to TO cord-009380-5uptbat3 37 15 know know VB cord-009380-5uptbat3 37 16 the the DT cord-009380-5uptbat3 37 17 state state NN cord-009380-5uptbat3 37 18 of of IN cord-009380-5uptbat3 37 19 the the DT cord-009380-5uptbat3 37 20 preclinical preclinical JJ cord-009380-5uptbat3 37 21 infection infection NN cord-009380-5uptbat3 37 22 , , , cord-009380-5uptbat3 37 23 econom- econom- VBG cord-009380-5uptbat3 37 24 ic ic JJ cord-009380-5uptbat3 37 25 incentives incentive NNS cord-009380-5uptbat3 37 26 to to TO cord-009380-5uptbat3 37 27 minimize minimize VB cord-009380-5uptbat3 37 28 disease disease NN cord-009380-5uptbat3 37 29 by by IN cord-009380-5uptbat3 37 30 effectively effectively RB cord-009380-5uptbat3 37 31 controlling control VBG cord-009380-5uptbat3 37 32 the the DT cord-009380-5uptbat3 37 33 infection infection NN cord-009380-5uptbat3 37 34 , , , cord-009380-5uptbat3 37 35 and and CC cord-009380-5uptbat3 37 36 concern concern NN cord-009380-5uptbat3 37 37 over over IN cord-009380-5uptbat3 37 38 potential potential JJ cord-009380-5uptbat3 37 39 zoonotic zoonotic JJ cord-009380-5uptbat3 37 40 diseases disease NNS cord-009380-5uptbat3 37 41 , , , cord-009380-5uptbat3 37 42 laboratory laboratory NN cord-009380-5uptbat3 37 43 diagnosis diagnosis NN cord-009380-5uptbat3 37 44 has have VBZ cord-009380-5uptbat3 37 45 taken take VBN cord-009380-5uptbat3 37 46 on on RP cord-009380-5uptbat3 37 47 a a DT cord-009380-5uptbat3 37 48 different different JJ cord-009380-5uptbat3 37 49 strategy strategy NN cord-009380-5uptbat3 37 50 . . . cord-009380-5uptbat3 38 1 This this DT cord-009380-5uptbat3 38 2 is be VBZ cord-009380-5uptbat3 38 3 presented present VBN cord-009380-5uptbat3 38 4 in in IN cord-009380-5uptbat3 38 5 Fig Fig NNP cord-009380-5uptbat3 38 6 . . . cord-009380-5uptbat3 39 1 2 2 LS cord-009380-5uptbat3 39 2 . . . cord-009380-5uptbat3 40 1 The the DT cord-009380-5uptbat3 40 2 primary primary JJ cord-009380-5uptbat3 40 3 emphasis emphasis NN cord-009380-5uptbat3 40 4 in in IN cord-009380-5uptbat3 40 5 this this DT cord-009380-5uptbat3 40 6 scheme scheme NN cord-009380-5uptbat3 40 7 is be VBZ cord-009380-5uptbat3 40 8 to to TO cord-009380-5uptbat3 40 9 view view VB cord-009380-5uptbat3 40 10 animals animal NNS cord-009380-5uptbat3 40 11 preclinical preclinical JJ cord-009380-5uptbat3 40 12 and and CC cord-009380-5uptbat3 40 13 determine determine VBP cord-009380-5uptbat3 40 14 the the DT cord-009380-5uptbat3 40 15 disease disease NN cord-009380-5uptbat3 40 16 risk risk NN cord-009380-5uptbat3 40 17 and/or and/or CC cord-009380-5uptbat3 40 18 zoonotic zoonotic JJ cord-009380-5uptbat3 40 19 potential potential NN cord-009380-5uptbat3 40 20 of of IN cord-009380-5uptbat3 40 21 the the DT cord-009380-5uptbat3 40 22 infection infection NN cord-009380-5uptbat3 40 23 . . . cord-009380-5uptbat3 41 1 This this DT cord-009380-5uptbat3 41 2 has have VBZ cord-009380-5uptbat3 41 3 been be VBN cord-009380-5uptbat3 41 4 the the DT cord-009380-5uptbat3 41 5 approach approach NN cord-009380-5uptbat3 41 6 for for IN cord-009380-5uptbat3 41 7 some some DT cord-009380-5uptbat3 41 8 retroviral retroviral JJ cord-009380-5uptbat3 41 9 infections infection NNS cord-009380-5uptbat3 41 10 ( ( -LRB- cord-009380-5uptbat3 41 11 Evermann Evermann NNP cord-009380-5uptbat3 41 12 and and CC cord-009380-5uptbat3 41 13 Jackson Jackson NNP cord-009380-5uptbat3 41 14 , , , cord-009380-5uptbat3 41 15 1997 1997 CD cord-009380-5uptbat3 41 16 ; ; : cord-009380-5uptbat3 41 17 Knowles Knowles NNP cord-009380-5uptbat3 41 18 , , , cord-009380-5uptbat3 41 19 1997 1997 CD cord-009380-5uptbat3 41 20 ) ) -RRB- cord-009380-5uptbat3 41 21 and and CC cord-009380-5uptbat3 41 22 bacterial bacterial JJ cord-009380-5uptbat3 41 23 infections infection NNS cord-009380-5uptbat3 41 24 with with IN cord-009380-5uptbat3 41 25 public public JJ cord-009380-5uptbat3 41 26 health health NN cord-009380-5uptbat3 41 27 concerns concern NNS cord-009380-5uptbat3 41 28 , , , cord-009380-5uptbat3 41 29 such such JJ cord-009380-5uptbat3 41 30 as as IN cord-009380-5uptbat3 41 31 E. E. NNP cord-009380-5uptbat3 41 32 coli coli NNS cord-009380-5uptbat3 41 33 O157 O157 NNP cord-009380-5uptbat3 41 34 : : : cord-009380-5uptbat3 42 1 H7 H7 NNP cord-009380-5uptbat3 42 2 and and CC cord-009380-5uptbat3 42 3 Salmonella Salmonella NNP cord-009380-5uptbat3 42 4 spp spp NNS cord-009380-5uptbat3 42 5 . . . cord-009380-5uptbat3 43 1 infections infection NNS cord-009380-5uptbat3 43 2 ( ( -LRB- cord-009380-5uptbat3 43 3 Evans Evans NNP cord-009380-5uptbat3 43 4 and and CC cord-009380-5uptbat3 43 5 Davies Davies NNP cord-009380-5uptbat3 43 6 , , , cord-009380-5uptbat3 43 7 1996 1996 CD cord-009380-5uptbat3 43 8 ; ; : cord-009380-5uptbat3 43 9 Firstenberg Firstenberg NNP cord-009380-5uptbat3 43 10 - - HYPH cord-009380-5uptbat3 43 11 Eden Eden NNP cord-009380-5uptbat3 43 12 and and CC cord-009380-5uptbat3 43 13 Sullivan Sullivan NNP cord-009380-5uptbat3 43 14 , , , cord-009380-5uptbat3 43 15 1997 1997 CD cord-009380-5uptbat3 43 16 ; ; : cord-009380-5uptbat3 43 17 McDonough McDonough NNP cord-009380-5uptbat3 43 18 and and CC cord-009380-5uptbat3 43 19 Simpson Simpson NNP cord-009380-5uptbat3 43 20 , , , cord-009380-5uptbat3 43 21 1996 1996 CD cord-009380-5uptbat3 43 22 ) ) -RRB- cord-009380-5uptbat3 43 23 . . . cord-009380-5uptbat3 44 1 The the DT cord-009380-5uptbat3 44 2 ultimate ultimate JJ cord-009380-5uptbat3 44 3 goal goal NN cord-009380-5uptbat3 44 4 of of IN cord-009380-5uptbat3 44 5 the the DT cord-009380-5uptbat3 44 6 assessment assessment NN cord-009380-5uptbat3 44 7 of of IN cord-009380-5uptbat3 44 8 preclinical preclinical JJ cord-009380-5uptbat3 44 9 testing testing NN cord-009380-5uptbat3 44 10 is be VBZ cord-009380-5uptbat3 44 11 to to TO cord-009380-5uptbat3 44 12 initiate initiate VB cord-009380-5uptbat3 44 13 a a DT cord-009380-5uptbat3 44 14 preventive preventive JJ cord-009380-5uptbat3 44 15 management management NN cord-009380-5uptbat3 44 16 type type NN cord-009380-5uptbat3 44 17 of of IN cord-009380-5uptbat3 44 18 control control NN cord-009380-5uptbat3 44 19 . . . cord-009380-5uptbat3 45 1 This this DT cord-009380-5uptbat3 45 2 type type NN cord-009380-5uptbat3 45 3 of of IN cord-009380-5uptbat3 45 4 approach approach NN cord-009380-5uptbat3 45 5 places place VBZ cord-009380-5uptbat3 45 6 more more JJR cord-009380-5uptbat3 45 7 emphasis emphasis NN cord-009380-5uptbat3 45 8 on on IN cord-009380-5uptbat3 45 9 early early JJ cord-009380-5uptbat3 45 10 testing testing NN cord-009380-5uptbat3 45 11 and and CC cord-009380-5uptbat3 45 12 management management NN cord-009380-5uptbat3 45 13 of of IN cord-009380-5uptbat3 45 14 infected infected JJ cord-009380-5uptbat3 45 15 animals animal NNS cord-009380-5uptbat3 45 16 rather rather RB cord-009380-5uptbat3 45 17 than than IN cord-009380-5uptbat3 45 18 on on IN cord-009380-5uptbat3 45 19 diseased diseased JJ cord-009380-5uptbat3 45 20 animals animal NNS cord-009380-5uptbat3 45 21 . . . cord-009380-5uptbat3 46 1 With with IN cord-009380-5uptbat3 46 2 the the DT cord-009380-5uptbat3 46 3 shift shift NN cord-009380-5uptbat3 46 4 in in IN cord-009380-5uptbat3 46 5 emphasis emphasis NN cord-009380-5uptbat3 46 6 to to IN cord-009380-5uptbat3 46 7 preclinical preclinical JJ cord-009380-5uptbat3 46 8 testing testing NN cord-009380-5uptbat3 46 9 , , , cord-009380-5uptbat3 46 10 the the DT cord-009380-5uptbat3 46 11 knowledge knowledge NN cord-009380-5uptbat3 46 12 of of IN cord-009380-5uptbat3 46 13 the the DT cord-009380-5uptbat3 46 14 ecology ecology NN cord-009380-5uptbat3 46 15 of of IN cord-009380-5uptbat3 46 16 the the DT cord-009380-5uptbat3 46 17 infectious infectious JJ cord-009380-5uptbat3 46 18 microorganism microorganism NN cord-009380-5uptbat3 46 19 has have VBZ cord-009380-5uptbat3 46 20 become become VBN cord-009380-5uptbat3 46 21 very very RB cord-009380-5uptbat3 46 22 important important JJ cord-009380-5uptbat3 46 23 in in IN cord-009380-5uptbat3 46 24 our -PRON- PRP$ cord-009380-5uptbat3 46 25 overall overall JJ cord-009380-5uptbat3 46 26 understanding understanding NN cord-009380-5uptbat3 46 27 of of IN cord-009380-5uptbat3 46 28 how how WRB cord-009380-5uptbat3 46 29 successful successful JJ cord-009380-5uptbat3 46 30 the the DT cord-009380-5uptbat3 46 31 control control NN cord-009380-5uptbat3 46 32 program program NN cord-009380-5uptbat3 46 33 may may MD cord-009380-5uptbat3 46 34 be be VB cord-009380-5uptbat3 46 35 ( ( -LRB- cord-009380-5uptbat3 46 36 Susser Susser NNP cord-009380-5uptbat3 46 37 and and CC cord-009380-5uptbat3 46 38 Susser Susser NNP cord-009380-5uptbat3 46 39 , , , cord-009380-5uptbat3 46 40 1996b 1996b CD cord-009380-5uptbat3 46 41 ) ) -RRB- cord-009380-5uptbat3 46 42 . . . cord-009380-5uptbat3 47 1 The the DT cord-009380-5uptbat3 47 2 control control NN cord-009380-5uptbat3 47 3 of of IN cord-009380-5uptbat3 47 4 infections infection NNS cord-009380-5uptbat3 47 5 with with IN cord-009380-5uptbat3 47 6 a a DT cord-009380-5uptbat3 47 7 low low JJ cord-009380-5uptbat3 47 8 degree degree NN cord-009380-5uptbat3 47 9 of of IN cord-009380-5uptbat3 47 10 transmissibility transmissibility NN cord-009380-5uptbat3 47 11 and and CC cord-009380-5uptbat3 47 12 narrow narrow JJ cord-009380-5uptbat3 47 13 host host NN cord-009380-5uptbat3 47 14 range range NN cord-009380-5uptbat3 47 15 , , , cord-009380-5uptbat3 47 16 such such JJ cord-009380-5uptbat3 47 17 as as IN cord-009380-5uptbat3 47 18 caprine caprine NN cord-009380-5uptbat3 47 19 arthritis arthritis NN cord-009380-5uptbat3 47 20 - - : cord-009380-5uptbat3 47 21 encephalitis encephalitis JJ cord-009380-5uptbat3 47 22 ( ( -LRB- cord-009380-5uptbat3 47 23 CAE CAE NNP cord-009380-5uptbat3 47 24 ) ) -RRB- cord-009380-5uptbat3 47 25 virus virus NN cord-009380-5uptbat3 47 26 , , , cord-009380-5uptbat3 47 27 is be VBZ cord-009380-5uptbat3 47 28 much much RB cord-009380-5uptbat3 47 29 more more RBR cord-009380-5uptbat3 47 30 realistic realistic JJ cord-009380-5uptbat3 47 31 than than IN cord-009380-5uptbat3 47 32 the the DT cord-009380-5uptbat3 47 33 control control NN cord-009380-5uptbat3 47 34 of of IN cord-009380-5uptbat3 47 35 diseases disease NNS cord-009380-5uptbat3 47 36 with with IN cord-009380-5uptbat3 47 37 a a DT cord-009380-5uptbat3 47 38 wide wide JJ cord-009380-5uptbat3 47 39 host host NN cord-009380-5uptbat3 47 40 range range NN cord-009380-5uptbat3 47 41 , , , cord-009380-5uptbat3 47 42 such such JJ cord-009380-5uptbat3 47 43 as as IN cord-009380-5uptbat3 47 44 chlamydia chlamydia NNS cord-009380-5uptbat3 47 45 and and CC cord-009380-5uptbat3 47 46 Salmonella Salmonella NNP cord-009380-5uptbat3 47 47 spp spp NNS cord-009380-5uptbat3 47 48 . . . cord-009380-5uptbat3 48 1 , , , cord-009380-5uptbat3 48 2 or or CC cord-009380-5uptbat3 48 3 those those DT cord-009380-5uptbat3 48 4 agents agent NNS cord-009380-5uptbat3 48 5 spread spread VBN cord-009380-5uptbat3 48 6 by by IN cord-009380-5uptbat3 48 7 arthropod arthropod JJ cord-009380-5uptbat3 48 8 vectors vector NNS cord-009380-5uptbat3 48 9 , , , cord-009380-5uptbat3 48 10 such such JJ cord-009380-5uptbat3 48 11 as as IN cord-009380-5uptbat3 48 12 arboviruses arbovirus NNS cord-009380-5uptbat3 48 13 and and CC cord-009380-5uptbat3 48 14 rickettsia rickettsia NNP cord-009380-5uptbat3 48 15 ( ( -LRB- cord-009380-5uptbat3 48 16 Gregory Gregory NNP cord-009380-5uptbat3 48 17 and and CC cord-009380-5uptbat3 48 18 Schaffner Schaffner NNP cord-009380-5uptbat3 48 19 , , , cord-009380-5uptbat3 48 20 1997 1997 CD cord-009380-5uptbat3 48 21 ; ; : cord-009380-5uptbat3 48 22 Hewinson Hewinson NNP cord-009380-5uptbat3 48 23 et et NNP cord-009380-5uptbat3 48 24 al al NNP cord-009380-5uptbat3 48 25 . . . cord-009380-5uptbat3 49 1 , , , cord-009380-5uptbat3 49 2 1997 1997 CD cord-009380-5uptbat3 49 3 ; ; : cord-009380-5uptbat3 49 4 Knowles Knowles NNP cord-009380-5uptbat3 49 5 , , , cord-009380-5uptbat3 49 6 1997 1997 CD cord-009380-5uptbat3 49 7 ; ; : cord-009380-5uptbat3 49 8 Raoult Raoult NNP cord-009380-5uptbat3 49 9 and and CC cord-009380-5uptbat3 49 10 Roux Roux NNP cord-009380-5uptbat3 49 11 , , , cord-009380-5uptbat3 49 12 1997 1997 CD cord-009380-5uptbat3 49 13 ; ; : cord-009380-5uptbat3 49 14 Saluzzo Saluzzo NNP cord-009380-5uptbat3 49 15 and and CC cord-009380-5uptbat3 49 16 Dodet Dodet NNP cord-009380-5uptbat3 49 17 , , , cord-009380-5uptbat3 49 18 1997 1997 CD cord-009380-5uptbat3 49 19 ) ) -RRB- cord-009380-5uptbat3 49 20 . . . cord-009380-5uptbat3 50 1 The the DT cord-009380-5uptbat3 50 2 ecology ecology NN cord-009380-5uptbat3 50 3 of of IN cord-009380-5uptbat3 50 4 infection infection NN cord-009380-5uptbat3 50 5 provides provide VBZ cord-009380-5uptbat3 50 6 the the DT cord-009380-5uptbat3 50 7 veterinarian veterinarian NN cord-009380-5uptbat3 50 8 with with IN cord-009380-5uptbat3 50 9 vital vital JJ cord-009380-5uptbat3 50 10 information information NN cord-009380-5uptbat3 50 11 with with IN cord-009380-5uptbat3 50 12 which which WDT cord-009380-5uptbat3 50 13 to to TO cord-009380-5uptbat3 50 14 make make VB cord-009380-5uptbat3 50 15 decisions decision NNS cord-009380-5uptbat3 50 16 . . . cord-009380-5uptbat3 51 1 The the DT cord-009380-5uptbat3 51 2 ecology ecology NN cord-009380-5uptbat3 51 3 of of IN cord-009380-5uptbat3 51 4 six six CD cord-009380-5uptbat3 51 5 different different JJ cord-009380-5uptbat3 51 6 agents agent NNS cord-009380-5uptbat3 51 7 is be VBZ cord-009380-5uptbat3 51 8 listed list VBN cord-009380-5uptbat3 51 9 in in IN cord-009380-5uptbat3 51 10 Table Table NNP cord-009380-5uptbat3 51 11 I -PRON- PRP cord-009380-5uptbat3 51 12 . . . cord-009380-5uptbat3 52 1 The the DT cord-009380-5uptbat3 52 2 ecology ecology NN cord-009380-5uptbat3 52 3 of of IN cord-009380-5uptbat3 52 4 infection infection NN cord-009380-5uptbat3 52 5 is be VBZ cord-009380-5uptbat3 52 6 divided divide VBN cord-009380-5uptbat3 52 7 into into IN cord-009380-5uptbat3 52 8 infection infection NN cord-009380-5uptbat3 52 9 rate rate NN cord-009380-5uptbat3 52 10 , , , cord-009380-5uptbat3 52 11 attack attack NN cord-009380-5uptbat3 52 12 rate rate NN cord-009380-5uptbat3 52 13 ( ( -LRB- cord-009380-5uptbat3 52 14 progress progress NN cord-009380-5uptbat3 52 15 to to TO cord-009380-5uptbat3 52 16 become become VB cord-009380-5uptbat3 52 17 clinical clinical JJ cord-009380-5uptbat3 52 18 ) ) -RRB- cord-009380-5uptbat3 52 19 , , , cord-009380-5uptbat3 52 20 and and CC cord-009380-5uptbat3 52 21 mortality mortality NN cord-009380-5uptbat3 52 22 rate rate NN cord-009380-5uptbat3 52 23 . . . cord-009380-5uptbat3 53 1 It -PRON- PRP cord-009380-5uptbat3 53 2 can can MD cord-009380-5uptbat3 53 3 be be VB cord-009380-5uptbat3 53 4 seen see VBN cord-009380-5uptbat3 53 5 that that IN cord-009380-5uptbat3 53 6 the the DT cord-009380-5uptbat3 53 7 infection infection NN cord-009380-5uptbat3 53 8 rate rate NN cord-009380-5uptbat3 53 9 usually usually RB cord-009380-5uptbat3 53 10 exceeds exceed VBZ cord-009380-5uptbat3 53 11 the the DT cord-009380-5uptbat3 53 12 attack attack NN cord-009380-5uptbat3 53 13 rate rate NN cord-009380-5uptbat3 53 14 and and CC cord-009380-5uptbat3 53 15 mortality mortality NN cord-009380-5uptbat3 53 16 rate rate NN cord-009380-5uptbat3 53 17 in in IN cord-009380-5uptbat3 53 18 the the DT cord-009380-5uptbat3 53 19 majority majority NN cord-009380-5uptbat3 53 20 of of IN cord-009380-5uptbat3 53 21 cases case NNS cord-009380-5uptbat3 53 22 . . . cord-009380-5uptbat3 54 1 Exceptions exception NNS cord-009380-5uptbat3 54 2 to to IN cord-009380-5uptbat3 54 3 this this DT cord-009380-5uptbat3 54 4 generalization generalization NN cord-009380-5uptbat3 54 5 are be VBP cord-009380-5uptbat3 54 6 the the DT cord-009380-5uptbat3 54 7 mucosal mucosal JJ cord-009380-5uptbat3 54 8 disease disease NN cord-009380-5uptbat3 54 9 form form NN cord-009380-5uptbat3 54 10 of of IN cord-009380-5uptbat3 54 11 BVD BVD NNP cord-009380-5uptbat3 54 12 that that WDT cord-009380-5uptbat3 54 13 occur occur VBP cord-009380-5uptbat3 54 14 in in IN cord-009380-5uptbat3 54 15 cattle cattle NNS cord-009380-5uptbat3 54 16 that that WDT cord-009380-5uptbat3 54 17 are be VBP cord-009380-5uptbat3 54 18 tolerant tolerant JJ cord-009380-5uptbat3 54 19 to to IN cord-009380-5uptbat3 54 20 BVD BVD NNP cord-009380-5uptbat3 54 21 and and CC cord-009380-5uptbat3 54 22 persistently persistently RB cord-009380-5uptbat3 54 23 infected infect VBN cord-009380-5uptbat3 54 24 ( ( -LRB- cord-009380-5uptbat3 54 25 PI PI NNP cord-009380-5uptbat3 54 26 ) ) -RRB- cord-009380-5uptbat3 54 27 , , , cord-009380-5uptbat3 54 28 and and CC cord-009380-5uptbat3 54 29 rabies rabies NN cord-009380-5uptbat3 54 30 infections infection NNS cord-009380-5uptbat3 54 31 in in IN cord-009380-5uptbat3 54 32 mammals mammal NNS cord-009380-5uptbat3 54 33 ( ( -LRB- cord-009380-5uptbat3 54 34 Innocent innocent JJ cord-009380-5uptbat3 54 35 et et FW cord-009380-5uptbat3 54 36 al al NNP cord-009380-5uptbat3 54 37 . . NNP cord-009380-5uptbat3 54 38 , , , cord-009380-5uptbat3 54 39 1997 1997 CD cord-009380-5uptbat3 54 40 ; ; : cord-009380-5uptbat3 54 41 Smith Smith NNP cord-009380-5uptbat3 54 42 , , , cord-009380-5uptbat3 54 43 1996 1996 CD cord-009380-5uptbat3 54 44 ) ) -RRB- cord-009380-5uptbat3 54 45 . . . cord-009380-5uptbat3 55 1 Another another DT cord-009380-5uptbat3 55 2 way way NN cord-009380-5uptbat3 55 3 to to TO cord-009380-5uptbat3 55 4 view view VB cord-009380-5uptbat3 55 5 the the DT cord-009380-5uptbat3 55 6 ecology ecology NN cord-009380-5uptbat3 55 7 of of IN cord-009380-5uptbat3 55 8 an an DT cord-009380-5uptbat3 55 9 infection infection NN cord-009380-5uptbat3 55 10 is be VBZ cord-009380-5uptbat3 55 11 demonstrated demonstrate VBN cord-009380-5uptbat3 55 12 in in IN cord-009380-5uptbat3 55 13 Fig Fig NNP cord-009380-5uptbat3 55 14 . . . cord-009380-5uptbat3 56 1 3 3 LS cord-009380-5uptbat3 56 2 . . . cord-009380-5uptbat3 57 1 The the DT cord-009380-5uptbat3 57 2 schematic schematic NN cord-009380-5uptbat3 57 3 allows allow VBZ cord-009380-5uptbat3 57 4 the the DT cord-009380-5uptbat3 57 5 veterinarian veterinarian NN cord-009380-5uptbat3 57 6 to to TO cord-009380-5uptbat3 57 7 readily readily RB cord-009380-5uptbat3 57 8 use use VB cord-009380-5uptbat3 57 9 a a DT cord-009380-5uptbat3 57 10 graphic graphic JJ cord-009380-5uptbat3 57 11 approach approach NN cord-009380-5uptbat3 57 12 with with IN cord-009380-5uptbat3 57 13 clients client NNS cord-009380-5uptbat3 57 14 to to TO cord-009380-5uptbat3 57 15 explain explain VB cord-009380-5uptbat3 57 16 the the DT cord-009380-5uptbat3 57 17 differences difference NNS cord-009380-5uptbat3 57 18 between between IN cord-009380-5uptbat3 57 19 infection infection NN cord-009380-5uptbat3 57 20 and and CC cord-009380-5uptbat3 57 21 disease disease NN cord-009380-5uptbat3 57 22 . . . cord-009380-5uptbat3 58 1 Rabies rabies NN cord-009380-5uptbat3 58 2 virus virus NN cord-009380-5uptbat3 58 3 is be VBZ cord-009380-5uptbat3 58 4 used use VBN cord-009380-5uptbat3 58 5 as as IN cord-009380-5uptbat3 58 6 an an DT cord-009380-5uptbat3 58 7 example example NN cord-009380-5uptbat3 58 8 of of IN cord-009380-5uptbat3 58 9 a a DT cord-009380-5uptbat3 58 10 microorganism microorganism NN cord-009380-5uptbat3 58 11 with with IN cord-009380-5uptbat3 58 12 a a DT cord-009380-5uptbat3 58 13 low low JJ cord-009380-5uptbat3 58 14 infection infection NN cord-009380-5uptbat3 58 15 rate rate NN cord-009380-5uptbat3 58 16 , , , cord-009380-5uptbat3 58 17 but but CC cord-009380-5uptbat3 58 18 high high JJ cord-009380-5uptbat3 58 19 mortality mortality NN cord-009380-5uptbat3 58 20 . . . cord-009380-5uptbat3 59 1 ( ( -LRB- cord-009380-5uptbat3 59 2 This this DT cord-009380-5uptbat3 59 3 figure figure NN cord-009380-5uptbat3 59 4 would would MD cord-009380-5uptbat3 59 5 be be VB cord-009380-5uptbat3 59 6 different different JJ cord-009380-5uptbat3 59 7 if if IN cord-009380-5uptbat3 59 8 one one PRP cord-009380-5uptbat3 59 9 were be VBD cord-009380-5uptbat3 59 10 to to TO cord-009380-5uptbat3 59 11 diagram diagram VB cord-009380-5uptbat3 59 12 the the DT cord-009380-5uptbat3 59 13 ecology ecology NN cord-009380-5uptbat3 59 14 of of IN cord-009380-5uptbat3 59 15 rabies rabie NNS cord-009380-5uptbat3 59 16 in in IN cord-009380-5uptbat3 59 17 bats bat NNS cord-009380-5uptbat3 59 18 , , , cord-009380-5uptbat3 59 19 the the DT cord-009380-5uptbat3 59 20 natural natural JJ cord-009380-5uptbat3 59 21 reservoir reservoir NN cord-009380-5uptbat3 59 22 for for IN cord-009380-5uptbat3 59 23 rabies rabie NNS cord-009380-5uptbat3 59 24 in in IN cord-009380-5uptbat3 59 25 the the DT cord-009380-5uptbat3 59 26 United United NNP cord-009380-5uptbat3 59 27 States States NNP cord-009380-5uptbat3 59 28 . . . cord-009380-5uptbat3 59 29 ) ) -RRB- cord-009380-5uptbat3 60 1 The the DT cord-009380-5uptbat3 60 2 CAE CAE NNP cord-009380-5uptbat3 60 3 virus virus NN cord-009380-5uptbat3 60 4 is be VBZ cord-009380-5uptbat3 60 5 used use VBN cord-009380-5uptbat3 60 6 as as IN cord-009380-5uptbat3 60 7 an an DT cord-009380-5uptbat3 60 8 example example NN cord-009380-5uptbat3 60 9 of of IN cord-009380-5uptbat3 60 10 an an DT cord-009380-5uptbat3 60 11 infection infection NN cord-009380-5uptbat3 60 12 in in IN cord-009380-5uptbat3 60 13 goats goat NNS cord-009380-5uptbat3 60 14 with with IN cord-009380-5uptbat3 60 15 a a DT cord-009380-5uptbat3 60 16 high high JJ cord-009380-5uptbat3 60 17 infection infection NN cord-009380-5uptbat3 60 18 rate rate NN cord-009380-5uptbat3 60 19 , , , cord-009380-5uptbat3 60 20 but but CC cord-009380-5uptbat3 60 21 lower low JJR cord-009380-5uptbat3 60 22 attack attack NN cord-009380-5uptbat3 60 23 rates rate NNS cord-009380-5uptbat3 60 24 , , , cord-009380-5uptbat3 60 25 and and CC cord-009380-5uptbat3 60 26 much much RB cord-009380-5uptbat3 60 27 lower low JJR cord-009380-5uptbat3 60 28 fatality fatality NN cord-009380-5uptbat3 60 29 rates rate NNS cord-009380-5uptbat3 60 30 ( ( -LRB- cord-009380-5uptbat3 60 31 Fig Fig NNP cord-009380-5uptbat3 60 32 . . NNP cord-009380-5uptbat3 60 33 4 4 CD cord-009380-5uptbat3 60 34 ) ) -RRB- cord-009380-5uptbat3 60 35 . . . cord-009380-5uptbat3 61 1 With with IN cord-009380-5uptbat3 61 2 retroviruses retrovirus NNS cord-009380-5uptbat3 61 3 , , , cord-009380-5uptbat3 61 4 such such JJ cord-009380-5uptbat3 61 5 as as IN cord-009380-5uptbat3 61 6 CAE CAE NNP cord-009380-5uptbat3 61 7 virus virus NN cord-009380-5uptbat3 61 8 , , , cord-009380-5uptbat3 61 9 bovine bovine JJ cord-009380-5uptbat3 61 10 leukosis leukosis NN cord-009380-5uptbat3 61 11 virus virus NN cord-009380-5uptbat3 61 12 ( ( -LRB- cord-009380-5uptbat3 61 13 BLV BLV NNP cord-009380-5uptbat3 61 14 ) ) -RRB- cord-009380-5uptbat3 61 15 , , , cord-009380-5uptbat3 61 16 and and CC cord-009380-5uptbat3 61 17 equine equine JJ cord-009380-5uptbat3 61 18 infectious infectious JJ cord-009380-5uptbat3 61 19 anemia anemia NN cord-009380-5uptbat3 61 20 ( ( -LRB- cord-009380-5uptbat3 61 21 EIA EIA NNP cord-009380-5uptbat3 61 22 ) ) -RRB- cord-009380-5uptbat3 61 23 , , , cord-009380-5uptbat3 61 24 the the DT cord-009380-5uptbat3 61 25 ecology ecology NN cord-009380-5uptbat3 61 26 can can MD cord-009380-5uptbat3 61 27 also also RB cord-009380-5uptbat3 61 28 be be VB cord-009380-5uptbat3 61 29 subdivided subdivide VBN cord-009380-5uptbat3 61 30 into into IN cord-009380-5uptbat3 61 31 progressor progressor NN cord-009380-5uptbat3 61 32 ( ( -LRB- cord-009380-5uptbat3 61 33 progress progress NN cord-009380-5uptbat3 61 34 onto onto IN cord-009380-5uptbat3 61 35 clinical clinical JJ cord-009380-5uptbat3 61 36 signs sign NNS cord-009380-5uptbat3 61 37 and/or and/or CC cord-009380-5uptbat3 61 38 fatality fatality NN cord-009380-5uptbat3 61 39 ) ) -RRB- cord-009380-5uptbat3 61 40 or or CC cord-009380-5uptbat3 61 41 nonprogressor nonprogressor NNP cord-009380-5uptbat3 61 42 ( ( -LRB- cord-009380-5uptbat3 61 43 remains remain VBZ cord-009380-5uptbat3 61 44 clinically clinically RB cord-009380-5uptbat3 61 45 normal normal JJ cord-009380-5uptbat3 61 46 , , , cord-009380-5uptbat3 61 47 but but CC cord-009380-5uptbat3 61 48 infected infected JJ cord-009380-5uptbat3 61 49 and and CC cord-009380-5uptbat3 61 50 potentially potentially RB cord-009380-5uptbat3 61 51 contagious contagious JJ cord-009380-5uptbat3 61 52 ) ) -RRB- cord-009380-5uptbat3 61 53 . . . cord-009380-5uptbat3 62 1 With with IN cord-009380-5uptbat3 62 2 persistent persistent JJ cord-009380-5uptbat3 62 3 bacterial bacterial JJ cord-009380-5uptbat3 62 4 infections infection NNS cord-009380-5uptbat3 62 5 , , , cord-009380-5uptbat3 62 6 such such JJ cord-009380-5uptbat3 62 7 as as IN cord-009380-5uptbat3 62 8 Salmonella Salmonella NNP cord-009380-5uptbat3 62 9 and and CC cord-009380-5uptbat3 62 10 many many JJ cord-009380-5uptbat3 62 11 members member NNS cord-009380-5uptbat3 62 12 of of IN cord-009380-5uptbat3 62 13 the the DT cord-009380-5uptbat3 62 14 Rickettsiaciae Rickettsiaciae NNP cord-009380-5uptbat3 62 15 , , , cord-009380-5uptbat3 62 16 the the DT cord-009380-5uptbat3 62 17 ecology ecology NN cord-009380-5uptbat3 62 18 can can MD cord-009380-5uptbat3 62 19 be be VB cord-009380-5uptbat3 62 20 subdivided subdivide VBN cord-009380-5uptbat3 62 21 into into IN cord-009380-5uptbat3 62 22 clinical clinical JJ cord-009380-5uptbat3 62 23 disease disease NN cord-009380-5uptbat3 62 24 leading lead VBG cord-009380-5uptbat3 62 25 to to IN cord-009380-5uptbat3 62 26 mortality mortality NN cord-009380-5uptbat3 62 27 or or CC cord-009380-5uptbat3 62 28 clinical clinical JJ cord-009380-5uptbat3 62 29 disease disease NN cord-009380-5uptbat3 62 30 leading lead VBG cord-009380-5uptbat3 62 31 to to IN cord-009380-5uptbat3 62 32 a a DT cord-009380-5uptbat3 62 33 chronic chronic JJ cord-009380-5uptbat3 62 34 carrier carrier NN cord-009380-5uptbat3 62 35 state state NN cord-009380-5uptbat3 62 36 . . . cord-009380-5uptbat3 63 1 This this DT cord-009380-5uptbat3 63 2 chronic chronic JJ cord-009380-5uptbat3 63 3 carrier carrier NN cord-009380-5uptbat3 63 4 state state NN cord-009380-5uptbat3 63 5 can can MD cord-009380-5uptbat3 63 6 then then RB cord-009380-5uptbat3 63 7 be be VB cord-009380-5uptbat3 63 8 further further RB cord-009380-5uptbat3 63 9 subdivided subdivide VBN cord-009380-5uptbat3 63 10 into into IN cord-009380-5uptbat3 63 11 inapparent inapparent JJ cord-009380-5uptbat3 63 12 infections infection NNS cord-009380-5uptbat3 63 13 with with IN cord-009380-5uptbat3 63 14 constant constant JJ cord-009380-5uptbat3 63 15 shredding shredding NN cord-009380-5uptbat3 63 16 and and CC cord-009380-5uptbat3 63 17 inapparent inapparent JJ cord-009380-5uptbat3 63 18 infections infection NNS cord-009380-5uptbat3 63 19 with with IN cord-009380-5uptbat3 63 20 intermittent intermittent JJ cord-009380-5uptbat3 63 21 shedding shedding NN cord-009380-5uptbat3 63 22 . . . cord-009380-5uptbat3 64 1 With with IN cord-009380-5uptbat3 64 2 potentially potentially RB cord-009380-5uptbat3 64 3 zoonotic zoonotic JJ cord-009380-5uptbat3 64 4 diseases disease NNS cord-009380-5uptbat3 64 5 , , , cord-009380-5uptbat3 64 6 such such JJ cord-009380-5uptbat3 64 7 as as IN cord-009380-5uptbat3 64 8 Salmonella Salmonella NNP cord-009380-5uptbat3 64 9 , , , cord-009380-5uptbat3 64 10 rickettsioses rickettsiose NNS cord-009380-5uptbat3 64 11 , , , cord-009380-5uptbat3 64 12 and and CC cord-009380-5uptbat3 64 13 psittacosis psittacosis NNP cord-009380-5uptbat3 64 14 ( ( -LRB- cord-009380-5uptbat3 64 15 Chlamydia Chlamydia NNP cord-009380-5uptbat3 64 16 psittici psittici NNP cord-009380-5uptbat3 64 17 ) ) -RRB- cord-009380-5uptbat3 64 18 , , , cord-009380-5uptbat3 64 19 the the DT cord-009380-5uptbat3 64 20 ability ability NN cord-009380-5uptbat3 64 21 to to TO cord-009380-5uptbat3 64 22 shed shed VB cord-009380-5uptbat3 64 23 or or CC cord-009380-5uptbat3 64 24 transmit transmit VB cord-009380-5uptbat3 64 25 the the DT cord-009380-5uptbat3 64 26 organism organism NN cord-009380-5uptbat3 64 27 into into IN cord-009380-5uptbat3 64 28 the the DT cord-009380-5uptbat3 64 29 environment environment NN cord-009380-5uptbat3 64 30 or or CC cord-009380-5uptbat3 64 31 vectors vector NNS cord-009380-5uptbat3 64 32 becomes become VBZ cord-009380-5uptbat3 64 33 particularly particularly RB cord-009380-5uptbat3 64 34 relevant relevant JJ cord-009380-5uptbat3 64 35 ( ( -LRB- cord-009380-5uptbat3 64 36 Evans Evans NNP cord-009380-5uptbat3 64 37 and and CC cord-009380-5uptbat3 64 38 Davies Davies NNP cord-009380-5uptbat3 64 39 , , , cord-009380-5uptbat3 64 40 1996 1996 CD cord-009380-5uptbat3 64 41 ; ; : cord-009380-5uptbat3 64 42 Gregory Gregory NNP cord-009380-5uptbat3 64 43 and and CC cord-009380-5uptbat3 64 44 Schaffner Schaffner NNP cord-009380-5uptbat3 64 45 , , , cord-009380-5uptbat3 64 46 1997 1997 CD cord-009380-5uptbat3 64 47 ; ; : cord-009380-5uptbat3 64 48 Raoult Raoult NNP cord-009380-5uptbat3 64 49 and and CC cord-009380-5uptbat3 64 50 Roux Roux NNP cord-009380-5uptbat3 64 51 , , , cord-009380-5uptbat3 64 52 1997 1997 CD cord-009380-5uptbat3 64 53 ) ) -RRB- cord-009380-5uptbat3 64 54 . . . cord-009380-5uptbat3 65 1 Early early JJ cord-009380-5uptbat3 65 2 detection detection NN cord-009380-5uptbat3 65 3 of of IN cord-009380-5uptbat3 65 4 infection infection NN cord-009380-5uptbat3 65 5 is be VBZ cord-009380-5uptbat3 65 6 now now RB cord-009380-5uptbat3 65 7 feasible feasible JJ cord-009380-5uptbat3 65 8 with with IN cord-009380-5uptbat3 65 9 a a DT cord-009380-5uptbat3 65 10 number number NN cord-009380-5uptbat3 65 11 of of IN cord-009380-5uptbat3 65 12 microorganisms microorganism NNS cord-009380-5uptbat3 65 13 affecting affect VBG cord-009380-5uptbat3 65 14 animals animal NNS cord-009380-5uptbat3 65 15 . . . cord-009380-5uptbat3 66 1 The the DT cord-009380-5uptbat3 66 2 detection detection NN cord-009380-5uptbat3 66 3 may may MD cord-009380-5uptbat3 66 4 take take VB cord-009380-5uptbat3 66 5 the the DT cord-009380-5uptbat3 66 6 form form NN cord-009380-5uptbat3 66 7 of of IN cord-009380-5uptbat3 66 8 specifically specifically RB cord-009380-5uptbat3 66 9 identifying identify VBG cord-009380-5uptbat3 66 10 the the DT cord-009380-5uptbat3 66 11 nucleic nucleic JJ cord-009380-5uptbat3 66 12 acid acid NN cord-009380-5uptbat3 66 13 of of IN cord-009380-5uptbat3 66 14 the the DT cord-009380-5uptbat3 66 15 infectious infectious JJ cord-009380-5uptbat3 66 16 agent agent NN cord-009380-5uptbat3 66 17 , , , cord-009380-5uptbat3 66 18 such such JJ cord-009380-5uptbat3 66 19 as as IN cord-009380-5uptbat3 66 20 bovine bovine JJ cord-009380-5uptbat3 66 21 herpesvirus-1 herpesvirus-1 NNP cord-009380-5uptbat3 66 22 in in IN cord-009380-5uptbat3 66 23 semen semen NN cord-009380-5uptbat3 66 24 samples sample NNS cord-009380-5uptbat3 66 25 , , , cord-009380-5uptbat3 66 26 BLV BLV NNP cord-009380-5uptbat3 66 27 provirus provirus NNP cord-009380-5uptbat3 66 28 is be VBZ cord-009380-5uptbat3 66 29 selected select VBN cord-009380-5uptbat3 66 30 blood blood NN cord-009380-5uptbat3 66 31 cells cell NNS cord-009380-5uptbat3 66 32 populations population NNS cord-009380-5uptbat3 66 33 , , , cord-009380-5uptbat3 66 34 and and CC cord-009380-5uptbat3 66 35 foodborne foodborne JJ cord-009380-5uptbat3 66 36 bacteria bacteria NNS cord-009380-5uptbat3 66 37 in in IN cord-009380-5uptbat3 66 38 dairy dairy NN cord-009380-5uptbat3 66 39 products product NNS cord-009380-5uptbat3 66 40 ( ( -LRB- cord-009380-5uptbat3 66 41 Batt Batt NNP cord-009380-5uptbat3 66 42 , , , cord-009380-5uptbat3 66 43 1997 1997 CD cord-009380-5uptbat3 66 44 ; ; . cord-009380-5uptbat3 67 1 Masri Masri NNP cord-009380-5uptbat3 67 2 et et NNP cord-009380-5uptbat3 67 3 al al NNP cord-009380-5uptbat3 67 4 . . . cord-009380-5uptbat3 68 1 , , , cord-009380-5uptbat3 68 2 1996 1996 CD cord-009380-5uptbat3 68 3 ; ; : cord-009380-5uptbat3 68 4 Xie Xie NNP cord-009380-5uptbat3 68 5 et et NNP cord-009380-5uptbat3 68 6 al al NNP cord-009380-5uptbat3 68 7 . . NNP cord-009380-5uptbat3 68 8 , , , cord-009380-5uptbat3 68 9 1997 1997 CD cord-009380-5uptbat3 68 10 ) ) -RRB- cord-009380-5uptbat3 68 11 . . . cord-009380-5uptbat3 69 1 Although although IN cord-009380-5uptbat3 69 2 this this DT cord-009380-5uptbat3 69 3 form form NN cord-009380-5uptbat3 69 4 of of IN cord-009380-5uptbat3 69 5 early early JJ cord-009380-5uptbat3 69 6 microbial microbial JJ cord-009380-5uptbat3 69 7 detection detection NN cord-009380-5uptbat3 69 8 is be VBZ cord-009380-5uptbat3 69 9 preclinical preclinical JJ cord-009380-5uptbat3 69 10 at at IN cord-009380-5uptbat3 69 11 this this DT cord-009380-5uptbat3 69 12 time time NN cord-009380-5uptbat3 69 13 , , , cord-009380-5uptbat3 69 14 with with IN cord-009380-5uptbat3 69 15 further further JJ cord-009380-5uptbat3 69 16 research research NN cord-009380-5uptbat3 69 17 it -PRON- PRP cord-009380-5uptbat3 69 18 may may MD cord-009380-5uptbat3 69 19 be be VB cord-009380-5uptbat3 69 20 determined determine VBN cord-009380-5uptbat3 69 21 that that IN cord-009380-5uptbat3 69 22 these these DT cord-009380-5uptbat3 69 23 " " `` cord-009380-5uptbat3 69 24 subclinical subclinical JJ cord-009380-5uptbat3 69 25 infections infection NNS cord-009380-5uptbat3 69 26 " " '' cord-009380-5uptbat3 69 27 are be VBP cord-009380-5uptbat3 69 28 actually actually RB cord-009380-5uptbat3 69 29 causing cause VBG cord-009380-5uptbat3 69 30 alterations alteration NNS cord-009380-5uptbat3 69 31 in in IN cord-009380-5uptbat3 69 32 cell cell NN cord-009380-5uptbat3 69 33 structure structure NN cord-009380-5uptbat3 69 34 and and CC cord-009380-5uptbat3 69 35 function function NN cord-009380-5uptbat3 69 36 leading lead VBG cord-009380-5uptbat3 69 37 to to IN cord-009380-5uptbat3 69 38 endocrine endocrine JJ cord-009380-5uptbat3 69 39 imbalances imbalance NNS cord-009380-5uptbat3 69 40 and and CC cord-009380-5uptbat3 69 41 decreased decrease VBD cord-009380-5uptbat3 69 42 productivity productivity NN cord-009380-5uptbat3 69 43 . . . cord-009380-5uptbat3 70 1 This this DT cord-009380-5uptbat3 70 2 form form NN cord-009380-5uptbat3 70 3 of of IN cord-009380-5uptbat3 70 4 disease disease NN cord-009380-5uptbat3 70 5 has have VBZ cord-009380-5uptbat3 70 6 been be VBN cord-009380-5uptbat3 70 7 referred refer VBN cord-009380-5uptbat3 70 8 to to IN cord-009380-5uptbat3 70 9 a a DT cord-009380-5uptbat3 70 10 " " `` cord-009380-5uptbat3 70 11 lesionless lesionless NN cord-009380-5uptbat3 70 12 pathology pathology NN cord-009380-5uptbat3 70 13 , , , cord-009380-5uptbat3 70 14 " " '' cord-009380-5uptbat3 70 15 and and CC cord-009380-5uptbat3 70 16 will will MD cord-009380-5uptbat3 70 17 be be VB cord-009380-5uptbat3 70 18 the the DT cord-009380-5uptbat3 70 19 subject subject NN cord-009380-5uptbat3 70 20 of of IN cord-009380-5uptbat3 70 21 further further JJ cord-009380-5uptbat3 70 22 research research NN cord-009380-5uptbat3 70 23 ( ( -LRB- cord-009380-5uptbat3 70 24 de de FW cord-009380-5uptbat3 70 25 la la NNP cord-009380-5uptbat3 70 26 Torre Torre NNP cord-009380-5uptbat3 70 27 and and CC cord-009380-5uptbat3 70 28 Oldstone Oldstone NNP cord-009380-5uptbat3 70 29 , , , cord-009380-5uptbat3 70 30 1996 1996 CD cord-009380-5uptbat3 70 31 ) ) -RRB- cord-009380-5uptbat3 70 32 . . . cord-009380-5uptbat3 71 1 Early early JJ cord-009380-5uptbat3 71 2 detection detection NN cord-009380-5uptbat3 71 3 of of IN cord-009380-5uptbat3 71 4 infection infection NN cord-009380-5uptbat3 71 5 may may MD cord-009380-5uptbat3 71 6 take take VB cord-009380-5uptbat3 71 7 a a DT cord-009380-5uptbat3 71 8 " " `` cord-009380-5uptbat3 71 9 back back JJ cord-009380-5uptbat3 71 10 door door NN cord-009380-5uptbat3 71 11 " " '' cord-009380-5uptbat3 71 12 approach approach NN cord-009380-5uptbat3 71 13 by by IN cord-009380-5uptbat3 71 14 analyzing analyze VBG cord-009380-5uptbat3 71 15 the the DT cord-009380-5uptbat3 71 16 host host NN cord-009380-5uptbat3 71 17 animal animal NN cord-009380-5uptbat3 71 18 's 's POS cord-009380-5uptbat3 71 19 genetic genetic JJ cord-009380-5uptbat3 71 20 predisposition predisposition NN cord-009380-5uptbat3 71 21 to to IN cord-009380-5uptbat3 71 22 infection infection NN cord-009380-5uptbat3 71 23 and and CC cord-009380-5uptbat3 71 24 disease disease NN cord-009380-5uptbat3 71 25 . . . cord-009380-5uptbat3 72 1 This this DT cord-009380-5uptbat3 72 2 interesting interesting JJ cord-009380-5uptbat3 72 3 approach approach NN cord-009380-5uptbat3 72 4 has have VBZ cord-009380-5uptbat3 72 5 already already RB cord-009380-5uptbat3 72 6 been be VBN cord-009380-5uptbat3 72 7 used use VBN cord-009380-5uptbat3 72 8 in in IN cord-009380-5uptbat3 72 9 order order NN cord-009380-5uptbat3 72 10 to to TO cord-009380-5uptbat3 72 11 control control VB cord-009380-5uptbat3 72 12 the the DT cord-009380-5uptbat3 72 13 prion prion NN cord-009380-5uptbat3 72 14 disease disease NN cord-009380-5uptbat3 72 15 , , , cord-009380-5uptbat3 72 16 scrapie scrapie NN cord-009380-5uptbat3 72 17 ( ( -LRB- cord-009380-5uptbat3 72 18 O'Rourke O'Rourke NNP cord-009380-5uptbat3 72 19 et et NNP cord-009380-5uptbat3 72 20 al al NNP cord-009380-5uptbat3 72 21 . . NNP cord-009380-5uptbat3 72 22 , , , cord-009380-5uptbat3 72 23 1997 1997 CD cord-009380-5uptbat3 72 24 ) ) -RRB- cord-009380-5uptbat3 72 25 . . . cord-009380-5uptbat3 73 1 Sheep Sheep NNS cord-009380-5uptbat3 73 2 with with IN cord-009380-5uptbat3 73 3 a a DT cord-009380-5uptbat3 73 4 unique unique JJ cord-009380-5uptbat3 73 5 chromosome chromosome NN cord-009380-5uptbat3 73 6 are be VBP cord-009380-5uptbat3 73 7 highly highly RB cord-009380-5uptbat3 73 8 susceptible susceptible JJ cord-009380-5uptbat3 73 9 to to IN cord-009380-5uptbat3 73 10 progress progress VB cord-009380-5uptbat3 73 11 onto onto IN cord-009380-5uptbat3 73 12 scrapie scrapie NN cord-009380-5uptbat3 73 13 , , , cord-009380-5uptbat3 73 14 an an DT cord-009380-5uptbat3 73 15 irreversible irreversible JJ cord-009380-5uptbat3 73 16 disease disease NN cord-009380-5uptbat3 73 17 . . . cord-009380-5uptbat3 74 1 Animals animal NNS cord-009380-5uptbat3 74 2 that that WDT cord-009380-5uptbat3 74 3 are be VBP cord-009380-5uptbat3 74 4 bred breed VBN cord-009380-5uptbat3 74 5 for for IN cord-009380-5uptbat3 74 6 genetic genetic JJ cord-009380-5uptbat3 74 7 resistance resistance NN cord-009380-5uptbat3 74 8 to to IN cord-009380-5uptbat3 74 9 infection infection NN cord-009380-5uptbat3 75 1 and/or and/or CC cord-009380-5uptbat3 75 2 disease disease NN cord-009380-5uptbat3 75 3 will will MD cord-009380-5uptbat3 75 4 be be VB cord-009380-5uptbat3 75 5 major major JJ cord-009380-5uptbat3 75 6 factors factor NNS cord-009380-5uptbat3 75 7 in in IN cord-009380-5uptbat3 75 8 disease disease NN cord-009380-5uptbat3 75 9 control control NN cord-009380-5uptbat3 75 10 in in IN cord-009380-5uptbat3 75 11 the the DT cord-009380-5uptbat3 75 12 future future NN cord-009380-5uptbat3 75 13 ( ( -LRB- cord-009380-5uptbat3 75 14 Gavora Gavora NNP cord-009380-5uptbat3 75 15 , , , cord-009380-5uptbat3 75 16 1996 1996 CD cord-009380-5uptbat3 75 17 ; ; : cord-009380-5uptbat3 75 18 Malo Malo NNP cord-009380-5uptbat3 75 19 and and CC cord-009380-5uptbat3 75 20 Skamene Skamene NNP cord-009380-5uptbat3 75 21 , , , cord-009380-5uptbat3 75 22 1994 1994 CD cord-009380-5uptbat3 75 23 ) ) -RRB- cord-009380-5uptbat3 75 24 . . . cord-009380-5uptbat3 76 1 The the DT cord-009380-5uptbat3 76 2 utilization utilization NN cord-009380-5uptbat3 76 3 of of IN cord-009380-5uptbat3 76 4 genetic genetic JJ cord-009380-5uptbat3 76 5 testing testing NN cord-009380-5uptbat3 76 6 is be VBZ cord-009380-5uptbat3 76 7 essential essential JJ cord-009380-5uptbat3 76 8 for for IN cord-009380-5uptbat3 76 9 some some DT cord-009380-5uptbat3 76 10 infections infection NNS cord-009380-5uptbat3 76 11 , , , cord-009380-5uptbat3 76 12 such such JJ cord-009380-5uptbat3 76 13 as as IN cord-009380-5uptbat3 76 14 the the DT cord-009380-5uptbat3 76 15 retroviruses retrovirus NNS cord-009380-5uptbat3 76 16 , , , cord-009380-5uptbat3 76 17 which which WDT cord-009380-5uptbat3 76 18 serve serve VBP cord-009380-5uptbat3 76 19 to to TO cord-009380-5uptbat3 76 20 activate activate VB cord-009380-5uptbat3 76 21 cellular cellular JJ cord-009380-5uptbat3 76 22 oncogenes oncogene NNS cord-009380-5uptbat3 76 23 and and CC cord-009380-5uptbat3 76 24 promote promote VB cord-009380-5uptbat3 76 25 disease disease NN cord-009380-5uptbat3 76 26 . . . cord-009380-5uptbat3 77 1 Identifying identify VBG cord-009380-5uptbat3 77 2 these these DT cord-009380-5uptbat3 77 3 cellular cellular JJ cord-009380-5uptbat3 77 4 oncogenes oncogene NNS cord-009380-5uptbat3 77 5 would would MD cord-009380-5uptbat3 77 6 be be VB cord-009380-5uptbat3 77 7 a a DT cord-009380-5uptbat3 77 8 major major JJ cord-009380-5uptbat3 77 9 step step NN cord-009380-5uptbat3 77 10 in in IN cord-009380-5uptbat3 77 11 controlling control VBG cord-009380-5uptbat3 77 12 retroviral retroviral NN cord-009380-5uptbat3 77 13 - - HYPH cord-009380-5uptbat3 77 14 induced induce VBN cord-009380-5uptbat3 77 15 diseases disease NNS cord-009380-5uptbat3 78 1 ( ( -LRB- cord-009380-5uptbat3 78 2 Wiedemann Wiedemann NNP cord-009380-5uptbat3 78 3 et et NNP cord-009380-5uptbat3 78 4 al al NNP cord-009380-5uptbat3 78 5 . . NNP cord-009380-5uptbat3 78 6 , , , cord-009380-5uptbat3 78 7 1991 1991 CD cord-009380-5uptbat3 78 8 ) ) -RRB- cord-009380-5uptbat3 78 9 . . . cord-009380-5uptbat3 79 1 It -PRON- PRP cord-009380-5uptbat3 79 2 will will MD cord-009380-5uptbat3 79 3 be be VB cord-009380-5uptbat3 79 4 essential essential JJ cord-009380-5uptbat3 79 5 to to TO cord-009380-5uptbat3 79 6 clearly clearly RB cord-009380-5uptbat3 79 7 define define VB cord-009380-5uptbat3 79 8 what what WP cord-009380-5uptbat3 79 9 the the DT cord-009380-5uptbat3 79 10 diagnostic diagnostic JJ cord-009380-5uptbat3 79 11 assay assay NN cord-009380-5uptbat3 79 12 is be VBZ cord-009380-5uptbat3 79 13 detecting detect VBG cord-009380-5uptbat3 79 14 so so IN cord-009380-5uptbat3 79 15 that that IN cord-009380-5uptbat3 79 16 the the DT cord-009380-5uptbat3 79 17 veterinarian veterinarian NN cord-009380-5uptbat3 79 18 may may MD cord-009380-5uptbat3 79 19 utilize utilize VB cord-009380-5uptbat3 79 20 the the DT cord-009380-5uptbat3 79 21 information information NN cord-009380-5uptbat3 79 22 appropriately appropriately RB cord-009380-5uptbat3 79 23 . . . cord-009380-5uptbat3 80 1 Figure figure NN cord-009380-5uptbat3 80 2 5a 5a CD cord-009380-5uptbat3 80 3 graphically graphically RB cord-009380-5uptbat3 80 4 presents present VBZ cord-009380-5uptbat3 80 5 the the DT cord-009380-5uptbat3 80 6 use use NN cord-009380-5uptbat3 80 7 of of IN cord-009380-5uptbat3 80 8 thresholds threshold NNS cord-009380-5uptbat3 80 9 to to TO cord-009380-5uptbat3 80 10 differentiate differentiate VB cord-009380-5uptbat3 80 11 subclinical subclinical JJ cord-009380-5uptbat3 80 12 infection infection NN cord-009380-5uptbat3 80 13 from from IN cord-009380-5uptbat3 80 14 clinical clinical JJ cord-009380-5uptbat3 80 15 manifestations manifestation NNS cord-009380-5uptbat3 80 16 of of IN cord-009380-5uptbat3 80 17 the the DT cord-009380-5uptbat3 80 18 disease disease NN cord-009380-5uptbat3 80 19 . . . cord-009380-5uptbat3 81 1 Figure figure NN cord-009380-5uptbat3 81 2 5b 5b NN cord-009380-5uptbat3 81 3 shows show VBZ cord-009380-5uptbat3 81 4 five five CD cord-009380-5uptbat3 81 5 potential potential JJ cord-009380-5uptbat3 81 6 diagnostic diagnostic JJ cord-009380-5uptbat3 81 7 assays assay NNS cord-009380-5uptbat3 81 8 , , , cord-009380-5uptbat3 81 9 each each DT cord-009380-5uptbat3 81 10 with with IN cord-009380-5uptbat3 81 11 varying vary VBG cord-009380-5uptbat3 81 12 levels level NNS cord-009380-5uptbat3 81 13 of of IN cord-009380-5uptbat3 81 14 sensitivity sensitivity NN cord-009380-5uptbat3 81 15 . . . cord-009380-5uptbat3 82 1 It -PRON- PRP cord-009380-5uptbat3 82 2 would would MD cord-009380-5uptbat3 82 3 be be VB cord-009380-5uptbat3 82 4 critical critical JJ cord-009380-5uptbat3 82 5 to to TO cord-009380-5uptbat3 82 6 understand understand VB cord-009380-5uptbat3 82 7 the the DT cord-009380-5uptbat3 82 8 differences difference NNS cord-009380-5uptbat3 82 9 between between IN cord-009380-5uptbat3 82 10 a a DT cord-009380-5uptbat3 82 11 test test NN cord-009380-5uptbat3 82 12 with with IN cord-009380-5uptbat3 82 13 high high JJ cord-009380-5uptbat3 82 14 sensitivity sensitivity NN cord-009380-5uptbat3 82 15 , , , cord-009380-5uptbat3 82 16 which which WDT cord-009380-5uptbat3 82 17 detects detect VBZ cord-009380-5uptbat3 82 18 subclinical subclinical JJ cord-009380-5uptbat3 82 19 infection infection NN cord-009380-5uptbat3 82 20 and and CC cord-009380-5uptbat3 82 21 a a DT cord-009380-5uptbat3 82 22 test test NN cord-009380-5uptbat3 82 23 with with IN cord-009380-5uptbat3 82 24 lesser less JJR cord-009380-5uptbat3 82 25 sensitivity sensitivity NN cord-009380-5uptbat3 82 26 , , , cord-009380-5uptbat3 82 27 but but CC cord-009380-5uptbat3 82 28 more more RBR cord-009380-5uptbat3 82 29 accurately accurately RB cord-009380-5uptbat3 82 30 diagnoses diagnose VBZ cord-009380-5uptbat3 82 31 disease disease NN cord-009380-5uptbat3 82 32 . . . cord-009380-5uptbat3 83 1 This this DT cord-009380-5uptbat3 83 2 question question NN cord-009380-5uptbat3 83 3 becomes become VBZ cord-009380-5uptbat3 83 4 more more RBR cord-009380-5uptbat3 83 5 difficult difficult JJ cord-009380-5uptbat3 83 6 the the DT cord-009380-5uptbat3 83 7 more more JJR cord-009380-5uptbat3 83 8 one one NN cord-009380-5uptbat3 83 9 employs employ VBZ cord-009380-5uptbat3 83 10 preclinical preclinical JJ cord-009380-5uptbat3 83 11 testing testing NN cord-009380-5uptbat3 83 12 in in IN cord-009380-5uptbat3 83 13 preventive preventive JJ cord-009380-5uptbat3 83 14 medicine medicine NN cord-009380-5uptbat3 83 15 programs program NNS cord-009380-5uptbat3 83 16 ( ( -LRB- cord-009380-5uptbat3 84 1 Clementi Clementi NNP cord-009380-5uptbat3 84 2 et et NNP cord-009380-5uptbat3 84 3 al al NNP cord-009380-5uptbat3 84 4 . . . cord-009380-5uptbat3 85 1 , , , cord-009380-5uptbat3 85 2 1995 1995 CD cord-009380-5uptbat3 85 3 ; ; : cord-009380-5uptbat3 85 4 Jacobson Jacobson NNP cord-009380-5uptbat3 85 5 and and CC cord-009380-5uptbat3 85 6 Romatowski Romatowski NNP cord-009380-5uptbat3 85 7 , , , cord-009380-5uptbat3 85 8 1996 1996 CD cord-009380-5uptbat3 85 9 ; ; : cord-009380-5uptbat3 85 10 Smith Smith NNP cord-009380-5uptbat3 85 11 , , , cord-009380-5uptbat3 85 12 1995 1995 CD cord-009380-5uptbat3 85 13 ) ) -RRB- cord-009380-5uptbat3 85 14 . . . cord-009380-5uptbat3 86 1 The the DT cord-009380-5uptbat3 86 2 predictive predictive JJ cord-009380-5uptbat3 86 3 value value NN cord-009380-5uptbat3 86 4 of of IN cord-009380-5uptbat3 86 5 a a DT cord-009380-5uptbat3 86 6 positive positive JJ cord-009380-5uptbat3 86 7 result result NN cord-009380-5uptbat3 86 8 may may MD cord-009380-5uptbat3 86 9 be be VB cord-009380-5uptbat3 86 10 high high JJ cord-009380-5uptbat3 86 11 when when WRB cord-009380-5uptbat3 86 12 an an DT cord-009380-5uptbat3 86 13 animal animal NN cord-009380-5uptbat3 86 14 is be VBZ cord-009380-5uptbat3 86 15 clinical clinical JJ cord-009380-5uptbat3 86 16 , , , cord-009380-5uptbat3 86 17 such such JJ cord-009380-5uptbat3 86 18 as as IN cord-009380-5uptbat3 86 19 a a DT cord-009380-5uptbat3 86 20 cat cat NN cord-009380-5uptbat3 86 21 with with IN cord-009380-5uptbat3 86 22 FIP FIP NNP cord-009380-5uptbat3 86 23 . . . cord-009380-5uptbat3 87 1 However however RB cord-009380-5uptbat3 87 2 , , , cord-009380-5uptbat3 87 3 with with IN cord-009380-5uptbat3 87 4 early early JJ cord-009380-5uptbat3 87 5 testing test VBG cord-009380-5uptbat3 87 6 the the DT cord-009380-5uptbat3 87 7 problems problem NNS cord-009380-5uptbat3 87 8 of of IN cord-009380-5uptbat3 87 9 detecting detect VBG cord-009380-5uptbat3 87 10 cross cross NN cord-009380-5uptbat3 87 11 - - JJ cord-009380-5uptbat3 87 12 reacting react VBG cord-009380-5uptbat3 87 13 viruses virus NNS cord-009380-5uptbat3 87 14 ( ( -LRB- cord-009380-5uptbat3 87 15 feline feline JJ cord-009380-5uptbat3 87 16 enteric enteric JJ cord-009380-5uptbat3 87 17 coronaviruses coronaviruse NNS cord-009380-5uptbat3 87 18 ) ) -RRB- cord-009380-5uptbat3 87 19 increases increase NNS cord-009380-5uptbat3 87 20 , , , cord-009380-5uptbat3 87 21 as as IN cord-009380-5uptbat3 87 22 does do VBZ cord-009380-5uptbat3 87 23 the the DT cord-009380-5uptbat3 87 24 question question NN cord-009380-5uptbat3 87 25 of of IN cord-009380-5uptbat3 87 26 whether whether IN cord-009380-5uptbat3 87 27 the the DT cord-009380-5uptbat3 87 28 preclinical preclinical JJ cord-009380-5uptbat3 87 29 result result NN cord-009380-5uptbat3 87 30 accurately accurately RB cord-009380-5uptbat3 87 31 identifies identify VBZ cord-009380-5uptbat3 87 32 an an DT cord-009380-5uptbat3 87 33 animal animal NN cord-009380-5uptbat3 87 34 that that WDT cord-009380-5uptbat3 87 35 is be VBZ cord-009380-5uptbat3 87 36 just just RB cord-009380-5uptbat3 87 37 infected infect VBN cord-009380-5uptbat3 87 38 or or CC cord-009380-5uptbat3 87 39 will will MD cord-009380-5uptbat3 87 40 progress progress VB cord-009380-5uptbat3 87 41 onto onto IN cord-009380-5uptbat3 87 42 disease disease NN cord-009380-5uptbat3 87 43 ( ( -LRB- cord-009380-5uptbat3 87 44 Evermann Evermann NNP cord-009380-5uptbat3 87 45 et et NNP cord-009380-5uptbat3 87 46 al al NNP cord-009380-5uptbat3 87 47 . . NNP cord-009380-5uptbat3 87 48 , , , cord-009380-5uptbat3 87 49 1995 1995 CD cord-009380-5uptbat3 87 50 ; ; : cord-009380-5uptbat3 87 51 Foley Foley NNP cord-009380-5uptbat3 87 52 et et NNP cord-009380-5uptbat3 87 53 al al NNP cord-009380-5uptbat3 87 54 . . NNP cord-009380-5uptbat3 87 55 , , , cord-009380-5uptbat3 87 56 1997 1997 CD cord-009380-5uptbat3 87 57 ) ) -RRB- cord-009380-5uptbat3 87 58 . . . cord-009380-5uptbat3 88 1 In in IN cord-009380-5uptbat3 88 2 infections infection NNS cord-009380-5uptbat3 88 3 such such JJ cord-009380-5uptbat3 88 4 as as IN cord-009380-5uptbat3 88 5 EIA EIA NNP cord-009380-5uptbat3 88 6 , , , cord-009380-5uptbat3 88 7 the the DT cord-009380-5uptbat3 88 8 consequences consequence NNS cord-009380-5uptbat3 88 9 of of IN cord-009380-5uptbat3 88 10 infection infection NN cord-009380-5uptbat3 88 11 are be VBP cord-009380-5uptbat3 88 12 just just RB cord-009380-5uptbat3 88 13 as as RB cord-009380-5uptbat3 88 14 severe severe JJ cord-009380-5uptbat3 88 15 as as IN cord-009380-5uptbat3 88 16 the the DT cord-009380-5uptbat3 88 17 horse horse NN cord-009380-5uptbat3 88 18 that that WDT cord-009380-5uptbat3 88 19 has have VBZ cord-009380-5uptbat3 88 20 clinical clinical JJ cord-009380-5uptbat3 88 21 signs sign NNS cord-009380-5uptbat3 88 22 of of IN cord-009380-5uptbat3 88 23 EIA EIA NNP cord-009380-5uptbat3 88 24 . . . cord-009380-5uptbat3 89 1 This this DT cord-009380-5uptbat3 89 2 is be VBZ cord-009380-5uptbat3 89 3 because because IN cord-009380-5uptbat3 89 4 the the DT cord-009380-5uptbat3 89 5 infection infection NN cord-009380-5uptbat3 89 6 is be VBZ cord-009380-5uptbat3 89 7 regulated regulate VBN cord-009380-5uptbat3 89 8 by by IN cord-009380-5uptbat3 89 9 the the DT cord-009380-5uptbat3 89 10 U.S. U.S. NNP cord-009380-5uptbat3 89 11 Department Department NNP cord-009380-5uptbat3 89 12 of of IN cord-009380-5uptbat3 89 13 Agriculture Agriculture NNP cord-009380-5uptbat3 89 14 and and CC cord-009380-5uptbat3 89 15 all all DT cord-009380-5uptbat3 89 16 seropositive seropositive JJ cord-009380-5uptbat3 89 17 horses horse NNS cord-009380-5uptbat3 89 18 and and CC cord-009380-5uptbat3 89 19 mules mule NNS cord-009380-5uptbat3 89 20 are be VBP cord-009380-5uptbat3 89 21 required require VBN cord-009380-5uptbat3 89 22 to to TO cord-009380-5uptbat3 89 23 be be VB cord-009380-5uptbat3 89 24 reported report VBN cord-009380-5uptbat3 89 25 , , , cord-009380-5uptbat3 89 26 regardless regardless RB cord-009380-5uptbat3 89 27 of of IN cord-009380-5uptbat3 89 28 their -PRON- PRP$ cord-009380-5uptbat3 89 29 health health NN cord-009380-5uptbat3 89 30 status status NN cord-009380-5uptbat3 89 31 . . . cord-009380-5uptbat3 90 1 Assays assay NNS cord-009380-5uptbat3 90 2 for for IN cord-009380-5uptbat3 90 3 early early JJ cord-009380-5uptbat3 90 4 detection detection NN cord-009380-5uptbat3 90 5 of of IN cord-009380-5uptbat3 90 6 EIA EIA NNP cord-009380-5uptbat3 90 7 infection infection NN cord-009380-5uptbat3 90 8 have have VBP cord-009380-5uptbat3 90 9 been be VBN cord-009380-5uptbat3 90 10 reported report VBN cord-009380-5uptbat3 90 11 to to TO cord-009380-5uptbat3 90 12 detect detect VB cord-009380-5uptbat3 90 13 viral viral JJ cord-009380-5uptbat3 90 14 RNA rna NN cord-009380-5uptbat3 90 15 in in IN cord-009380-5uptbat3 90 16 plasma plasma NN cord-009380-5uptbat3 90 17 samples sample NNS cord-009380-5uptbat3 90 18 as as RB cord-009380-5uptbat3 90 19 early early RB cord-009380-5uptbat3 90 20 as as IN cord-009380-5uptbat3 90 21 48 48 CD cord-009380-5uptbat3 90 22 hours hour NNS cord-009380-5uptbat3 90 23 after after IN cord-009380-5uptbat3 90 24 infection infection NN cord-009380-5uptbat3 91 1 ( ( -LRB- cord-009380-5uptbat3 91 2 Langemeier Langemeier NNP cord-009380-5uptbat3 91 3 et et NNP cord-009380-5uptbat3 91 4 al al NNP cord-009380-5uptbat3 91 5 . . NNP cord-009380-5uptbat3 91 6 , , , cord-009380-5uptbat3 91 7 1996 1996 CD cord-009380-5uptbat3 91 8 ) ) -RRB- cord-009380-5uptbat3 91 9 . . . cord-009380-5uptbat3 92 1 Similarly similarly RB cord-009380-5uptbat3 92 2 in in IN cord-009380-5uptbat3 92 3 bovine bovine JJ cord-009380-5uptbat3 92 4 tuberculosis tuberculosis NN cord-009380-5uptbat3 92 5 , , , cord-009380-5uptbat3 92 6 caused cause VBD cord-009380-5uptbat3 92 7 byMycobacterium byMycobacterium NNP cord-009380-5uptbat3 92 8 bovis bovi NNS cord-009380-5uptbat3 92 9 , , , cord-009380-5uptbat3 92 10 the the DT cord-009380-5uptbat3 92 11 consequences consequence NNS cord-009380-5uptbat3 92 12 of of IN cord-009380-5uptbat3 92 13 a a DT cord-009380-5uptbat3 92 14 positive positive JJ cord-009380-5uptbat3 92 15 test test NN cord-009380-5uptbat3 92 16 result result NN cord-009380-5uptbat3 92 17 can can MD cord-009380-5uptbat3 92 18 be be VB cord-009380-5uptbat3 92 19 economically economically RB cord-009380-5uptbat3 92 20 devastating devastating JJ cord-009380-5uptbat3 92 21 due due IN cord-009380-5uptbat3 92 22 to to IN cord-009380-5uptbat3 92 23 stringent stringent JJ cord-009380-5uptbat3 92 24 government government NN cord-009380-5uptbat3 92 25 regulations regulation NNS cord-009380-5uptbat3 92 26 . . . cord-009380-5uptbat3 93 1 This this DT cord-009380-5uptbat3 93 2 becomes become VBZ cord-009380-5uptbat3 93 3 particularly particularly RB cord-009380-5uptbat3 93 4 problematic problematic JJ cord-009380-5uptbat3 93 5 because because IN cord-009380-5uptbat3 93 6 many many JJ cord-009380-5uptbat3 93 7 tests test NNS cord-009380-5uptbat3 93 8 currently currently RB cord-009380-5uptbat3 93 9 available available JJ cord-009380-5uptbat3 93 10 may may MD cord-009380-5uptbat3 93 11 cross cross VB cord-009380-5uptbat3 93 12 - - VB cord-009380-5uptbat3 93 13 react react VB cord-009380-5uptbat3 93 14 with with IN cord-009380-5uptbat3 93 15 other other JJ cord-009380-5uptbat3 93 16 mycobacterial mycobacterial JJ cord-009380-5uptbat3 93 17 species specie NNS cord-009380-5uptbat3 93 18 ( ( -LRB- cord-009380-5uptbat3 93 19 Essey Essey NNP cord-009380-5uptbat3 93 20 and and CC cord-009380-5uptbat3 93 21 Koller Koller NNP cord-009380-5uptbat3 93 22 , , , cord-009380-5uptbat3 93 23 1994 1994 CD cord-009380-5uptbat3 93 24 ; ; : cord-009380-5uptbat3 93 25 O'Reilly O'Reilly NNP cord-009380-5uptbat3 93 26 and and CC cord-009380-5uptbat3 93 27 Daborn Daborn NNP cord-009380-5uptbat3 93 28 , , , cord-009380-5uptbat3 93 29 1995 1995 CD cord-009380-5uptbat3 93 30 ) ) -RRB- cord-009380-5uptbat3 93 31 . . . cord-009380-5uptbat3 94 1 To to TO cord-009380-5uptbat3 94 2 determine determine VB cord-009380-5uptbat3 94 3 what what WP cord-009380-5uptbat3 94 4 consequences consequence VBZ cord-009380-5uptbat3 94 5 the the DT cord-009380-5uptbat3 94 6 test test NN cord-009380-5uptbat3 94 7 results result NNS cord-009380-5uptbat3 94 8 will will MD cord-009380-5uptbat3 94 9 have have VB cord-009380-5uptbat3 94 10 on on IN cord-009380-5uptbat3 94 11 the the DT cord-009380-5uptbat3 94 12 animal animal NN cord-009380-5uptbat3 94 13 and and CC cord-009380-5uptbat3 94 14 the the DT cord-009380-5uptbat3 94 15 owner owner NN cord-009380-5uptbat3 94 16 it -PRON- PRP cord-009380-5uptbat3 94 17 is be VBZ cord-009380-5uptbat3 94 18 important important JJ cord-009380-5uptbat3 94 19 to to TO cord-009380-5uptbat3 94 20 ask ask VB cord-009380-5uptbat3 94 21 five five CD cord-009380-5uptbat3 94 22 key key JJ cord-009380-5uptbat3 94 23 questions question NNS cord-009380-5uptbat3 94 24 ( ( -LRB- cord-009380-5uptbat3 94 25 Table Table NNP cord-009380-5uptbat3 94 26 _SP cord-009380-5uptbat3 94 27 II II NNP cord-009380-5uptbat3 94 28 ) ) -RRB- cord-009380-5uptbat3 94 29 . . . cord-009380-5uptbat3 95 1 Is be VBZ cord-009380-5uptbat3 95 2 the the DT cord-009380-5uptbat3 95 3 infection infection NN cord-009380-5uptbat3 96 1 and/or and/or CC cord-009380-5uptbat3 96 2 disease disease NN cord-009380-5uptbat3 96 3 of of IN cord-009380-5uptbat3 96 4 economic economic JJ cord-009380-5uptbat3 96 5 concern concern NN cord-009380-5uptbat3 96 6 , , , cord-009380-5uptbat3 96 7 such such JJ cord-009380-5uptbat3 96 8 as as IN cord-009380-5uptbat3 96 9 EIA EIA NNP cord-009380-5uptbat3 96 10 or or CC cord-009380-5uptbat3 96 11 M. M. NNP cord-009380-5uptbat3 96 12 bovis bovi NNS cord-009380-5uptbat3 96 13 ; ; : cord-009380-5uptbat3 96 14 is be VBZ cord-009380-5uptbat3 96 15 the the DT cord-009380-5uptbat3 96 16 infection infection NN cord-009380-5uptbat3 96 17 and/or and/or CC cord-009380-5uptbat3 96 18 disease disease NN cord-009380-5uptbat3 96 19 of of IN cord-009380-5uptbat3 96 20 zoonotic zoonotic JJ cord-009380-5uptbat3 96 21 concern concern NN cord-009380-5uptbat3 96 22 , , , cord-009380-5uptbat3 96 23 such such JJ cord-009380-5uptbat3 96 24 as as IN cord-009380-5uptbat3 96 25 E. E. NNP cord-009380-5uptbat3 96 26 coli coli VBZ cord-009380-5uptbat3 96 27 0157 0157 CD cord-009380-5uptbat3 96 28 : : : cord-009380-5uptbat3 97 1 H7 H7 NNP cord-009380-5uptbat3 97 2 ; ; : cord-009380-5uptbat3 97 3 where where WRB cord-009380-5uptbat3 97 4 is be VBZ cord-009380-5uptbat3 97 5 the the DT cord-009380-5uptbat3 97 6 microbial microbial JJ cord-009380-5uptbat3 97 7 agent agent NN cord-009380-5uptbat3 97 8 when when WRB cord-009380-5uptbat3 97 9 not not RB cord-009380-5uptbat3 97 10 causing cause VBG cord-009380-5uptbat3 97 11 disease disease NN cord-009380-5uptbat3 97 12 , , , cord-009380-5uptbat3 97 13 such such JJ cord-009380-5uptbat3 97 14 as as IN cord-009380-5uptbat3 97 15 with with IN cord-009380-5uptbat3 97 16 rabies rabies NN cord-009380-5uptbat3 97 17 reservoirs reservoir NNS cord-009380-5uptbat3 97 18 in in IN cord-009380-5uptbat3 97 19 bat bat NN cord-009380-5uptbat3 97 20 populations population NNS cord-009380-5uptbat3 97 21 ; ; : cord-009380-5uptbat3 97 22 what what WP cord-009380-5uptbat3 97 23 are be VBP cord-009380-5uptbat3 97 24 the the DT cord-009380-5uptbat3 97 25 contributing contribute VBG cord-009380-5uptbat3 97 26 factors factor NNS cord-009380-5uptbat3 97 27 to to IN cord-009380-5uptbat3 97 28 the the DT cord-009380-5uptbat3 97 29 infection infection NN cord-009380-5uptbat3 97 30 and/or and/or CC cord-009380-5uptbat3 97 31 disease disease NN cord-009380-5uptbat3 97 32 process process NN cord-009380-5uptbat3 97 33 , , , cord-009380-5uptbat3 97 34 such such JJ cord-009380-5uptbat3 97 35 as as IN cord-009380-5uptbat3 97 36 pregnancy pregnancy NN cord-009380-5uptbat3 97 37 for for IN cord-009380-5uptbat3 97 38 CHV CHV NNP cord-009380-5uptbat3 97 39 and and CC cord-009380-5uptbat3 97 40 other other JJ cord-009380-5uptbat3 97 41 herpesviruses herpesviruse NNS cord-009380-5uptbat3 97 42 ; ; : cord-009380-5uptbat3 97 43 and and CC cord-009380-5uptbat3 98 1 what what WDT cord-009380-5uptbat3 98 2 factors factor NNS cord-009380-5uptbat3 98 3 can can MD cord-009380-5uptbat3 98 4 animal animal NN cord-009380-5uptbat3 98 5 owners owner NNS cord-009380-5uptbat3 98 6 / / SYM cord-009380-5uptbat3 98 7 veterinarians veterinarian NNS cord-009380-5uptbat3 98 8 / / SYM cord-009380-5uptbat3 98 9 public public JJ cord-009380-5uptbat3 98 10 health health NN cord-009380-5uptbat3 98 11 personnel personnel NNS cord-009380-5uptbat3 98 12 control control NN cord-009380-5uptbat3 98 13 to to TO cord-009380-5uptbat3 98 14 minimize minimize VB cord-009380-5uptbat3 98 15 or or CC cord-009380-5uptbat3 98 16 eliminate eliminate VB cord-009380-5uptbat3 98 17 the the DT cord-009380-5uptbat3 98 18 risk risk NN cord-009380-5uptbat3 98 19 of of IN cord-009380-5uptbat3 98 20 infection infection NN cord-009380-5uptbat3 98 21 and/or and/or CC cord-009380-5uptbat3 98 22 the the DT cord-009380-5uptbat3 98 23 disease disease NN cord-009380-5uptbat3 98 24 process process NN cord-009380-5uptbat3 98 25 ? ? . cord-009380-5uptbat3 99 1 Table table NN cord-009380-5uptbat3 99 2 III iii CD cord-009380-5uptbat3 99 3 lists list VBZ cord-009380-5uptbat3 99 4 some some DT cord-009380-5uptbat3 99 5 of of IN cord-009380-5uptbat3 99 6 the the DT cord-009380-5uptbat3 99 7 consequences consequence NNS cord-009380-5uptbat3 99 8 of of IN cord-009380-5uptbat3 99 9 the the DT cord-009380-5uptbat3 99 10 infection infection NN cord-009380-5uptbat3 100 1 and/or and/or CC cord-009380-5uptbat3 100 2 disease disease NN cord-009380-5uptbat3 100 3 process process NN cord-009380-5uptbat3 100 4 . . . cord-009380-5uptbat3 101 1 These these DT cord-009380-5uptbat3 101 2 range range VBP cord-009380-5uptbat3 101 3 from from IN cord-009380-5uptbat3 101 4 no no DT cord-009380-5uptbat3 101 5 sale sale NN cord-009380-5uptbat3 101 6 , , , cord-009380-5uptbat3 101 7 as as IN cord-009380-5uptbat3 101 8 with with IN cord-009380-5uptbat3 101 9 a a DT cord-009380-5uptbat3 101 10 goat goat NN cord-009380-5uptbat3 101 11 that that WDT cord-009380-5uptbat3 101 12 is be VBZ cord-009380-5uptbat3 101 13 CAE CAE NNP cord-009380-5uptbat3 101 14 seropositive seropositive JJ cord-009380-5uptbat3 101 15 , , , cord-009380-5uptbat3 101 16 to to TO cord-009380-5uptbat3 101 17 euthanasia euthanasia VB cord-009380-5uptbat3 101 18 if if IN cord-009380-5uptbat3 101 19 a a DT cord-009380-5uptbat3 101 20 horse horse NN cord-009380-5uptbat3 101 21 or or CC cord-009380-5uptbat3 101 22 mule mule NN cord-009380-5uptbat3 101 23 is be VBZ cord-009380-5uptbat3 101 24 tested test VBN cord-009380-5uptbat3 101 25 EIA EIA NNP cord-009380-5uptbat3 101 26 seropositive seropositive JJ cord-009380-5uptbat3 101 27 . . . cord-009380-5uptbat3 102 1 V. V. NNP cord-009380-5uptbat3 103 1 Where where WRB cord-009380-5uptbat3 103 2 Are be VBP cord-009380-5uptbat3 103 3 We -PRON- PRP cord-009380-5uptbat3 103 4 Heading head VBG cord-009380-5uptbat3 103 5 with with IN cord-009380-5uptbat3 103 6 Veterinary Veterinary NNP cord-009380-5uptbat3 103 7 Diagnostics diagnostic NNS cord-009380-5uptbat3 103 8 ? ? . cord-009380-5uptbat3 104 1 Veterinary veterinary JJ cord-009380-5uptbat3 104 2 diagnostics diagnostic NNS cord-009380-5uptbat3 104 3 , , , cord-009380-5uptbat3 104 4 like like IN cord-009380-5uptbat3 104 5 their -PRON- PRP$ cord-009380-5uptbat3 104 6 human human JJ cord-009380-5uptbat3 104 7 counterparts counterpart NNS cord-009380-5uptbat3 104 8 , , , cord-009380-5uptbat3 104 9 are be VBP cord-009380-5uptbat3 104 10 already already RB cord-009380-5uptbat3 104 11 directing direct VBG cord-009380-5uptbat3 104 12 efforts effort NNS cord-009380-5uptbat3 104 13 toward toward IN cord-009380-5uptbat3 104 14 more more RBR cord-009380-5uptbat3 104 15 sensitive sensitive JJ cord-009380-5uptbat3 104 16 assays assay NNS cord-009380-5uptbat3 104 17 , , , cord-009380-5uptbat3 104 18 which which WDT cord-009380-5uptbat3 104 19 are be VBP cord-009380-5uptbat3 104 20 capable capable JJ cord-009380-5uptbat3 104 21 of of IN cord-009380-5uptbat3 104 22 detecting detect VBG cord-009380-5uptbat3 104 23 infections infection NNS cord-009380-5uptbat3 104 24 very very RB cord-009380-5uptbat3 104 25 early early RB cord-009380-5uptbat3 104 26 ( ( -LRB- cord-009380-5uptbat3 104 27 within within IN cord-009380-5uptbat3 104 28 hours hour NNS cord-009380-5uptbat3 104 29 of of IN cord-009380-5uptbat3 104 30 initial initial JJ cord-009380-5uptbat3 104 31 infection infection NN cord-009380-5uptbat3 104 32 ) ) -RRB- cord-009380-5uptbat3 104 33 ; ; , cord-009380-5uptbat3 104 34 subclinical subclinical JJ cord-009380-5uptbat3 104 35 infections infection NNS cord-009380-5uptbat3 104 36 that that WDT cord-009380-5uptbat3 104 37 are be VBP cord-009380-5uptbat3 104 38 the the DT cord-009380-5uptbat3 104 39 result result NN cord-009380-5uptbat3 104 40 of of IN cord-009380-5uptbat3 104 41 persistent persistent JJ cord-009380-5uptbat3 104 42 infections infection NNS cord-009380-5uptbat3 104 43 acquired acquire VBN cord-009380-5uptbat3 104 44 during during IN cord-009380-5uptbat3 104 45 gestation gestation NN cord-009380-5uptbat3 104 46 and and CC cord-009380-5uptbat3 104 47 masked mask VBN cord-009380-5uptbat3 104 48 by by IN cord-009380-5uptbat3 104 49 immune immune JJ cord-009380-5uptbat3 104 50 tolerance tolerance NN cord-009380-5uptbat3 104 51 ; ; , cord-009380-5uptbat3 104 52 latent latent JJ cord-009380-5uptbat3 104 53 infections infection NNS cord-009380-5uptbat3 104 54 due due JJ cord-009380-5uptbat3 104 55 to to IN cord-009380-5uptbat3 104 56 herpesviruses herpesviruse NNS cord-009380-5uptbat3 104 57 and and CC cord-009380-5uptbat3 104 58 retroviruses retrovirus NNS cord-009380-5uptbat3 104 59 ; ; : cord-009380-5uptbat3 104 60 and and CC cord-009380-5uptbat3 104 61 infections infection NNS cord-009380-5uptbat3 104 62 that that WDT cord-009380-5uptbat3 104 63 pose pose VBP cord-009380-5uptbat3 104 64 a a DT cord-009380-5uptbat3 104 65 public public JJ cord-009380-5uptbat3 104 66 health health NN cord-009380-5uptbat3 104 67 risk risk NN cord-009380-5uptbat3 104 68 ( ( -LRB- cord-009380-5uptbat3 104 69 Barrett Barrett NNP cord-009380-5uptbat3 104 70 et et NNP cord-009380-5uptbat3 104 71 al al NNP cord-009380-5uptbat3 104 72 . . NNP cord-009380-5uptbat3 104 73 , , , cord-009380-5uptbat3 104 74 1997 1997 CD cord-009380-5uptbat3 104 75 ; ; : cord-009380-5uptbat3 104 76 Burr Burr NNP cord-009380-5uptbat3 104 77 , , , cord-009380-5uptbat3 104 78 1996 1996 CD cord-009380-5uptbat3 104 79 ; ; : cord-009380-5uptbat3 104 80 Clarke Clarke NNP cord-009380-5uptbat3 104 81 , , , cord-009380-5uptbat3 104 82 1997 1997 CD cord-009380-5uptbat3 104 83 ; ; : cord-009380-5uptbat3 104 84 de de NNP cord-009380-5uptbat3 104 85 la la NNP cord-009380-5uptbat3 104 86 Torre Torre NNP cord-009380-5uptbat3 104 87 and and CC cord-009380-5uptbat3 104 88 Oldstone Oldstone NNP cord-009380-5uptbat3 104 89 , , , cord-009380-5uptbat3 104 90 1996 1996 CD cord-009380-5uptbat3 104 91 ; ; : cord-009380-5uptbat3 104 92 Rodriquez Rodriquez NNP cord-009380-5uptbat3 104 93 , , , cord-009380-5uptbat3 104 94 1997 1997 CD cord-009380-5uptbat3 104 95 ) ) -RRB- cord-009380-5uptbat3 104 96 . . . cord-009380-5uptbat3 105 1 The the DT cord-009380-5uptbat3 105 2 evolution evolution NN cord-009380-5uptbat3 105 3 of of IN cord-009380-5uptbat3 105 4 diseases disease NNS cord-009380-5uptbat3 105 5 and and CC cord-009380-5uptbat3 105 6 the the DT cord-009380-5uptbat3 105 7 emergence emergence NN cord-009380-5uptbat3 105 8 of of IN cord-009380-5uptbat3 105 9 newly newly RB cord-009380-5uptbat3 105 10 recognized recognize VBN cord-009380-5uptbat3 105 11 pathogens pathogen NNS cord-009380-5uptbat3 105 12 have have VBP cord-009380-5uptbat3 105 13 placed place VBN cord-009380-5uptbat3 105 14 considerable considerable JJ cord-009380-5uptbat3 105 15 pressure pressure NN cord-009380-5uptbat3 105 16 on on IN cord-009380-5uptbat3 105 17 new new JJ cord-009380-5uptbat3 105 18 diagnostic diagnostic JJ cord-009380-5uptbat3 105 19 technologies technology NNS cord-009380-5uptbat3 105 20 . . . cord-009380-5uptbat3 106 1 The the DT cord-009380-5uptbat3 106 2 newer new JJR cord-009380-5uptbat3 106 3 assays assay NNS cord-009380-5uptbat3 106 4 will will MD cord-009380-5uptbat3 106 5 assist assist VB cord-009380-5uptbat3 106 6 in in IN cord-009380-5uptbat3 106 7 tracking track VBG cord-009380-5uptbat3 106 8 the the DT cord-009380-5uptbat3 106 9 emerging emerge VBG cord-009380-5uptbat3 106 10 infections infection NNS cord-009380-5uptbat3 106 11 , , , cord-009380-5uptbat3 106 12 as as RB cord-009380-5uptbat3 106 13 well well RB cord-009380-5uptbat3 106 14 as as IN cord-009380-5uptbat3 106 15 linking link VBG cord-009380-5uptbat3 106 16 causal causal NNP cord-009380-5uptbat3 106 17 association association NNP cord-009380-5uptbat3 106 18 with with IN cord-009380-5uptbat3 106 19 disease disease NN cord-009380-5uptbat3 106 20 to to IN cord-009380-5uptbat3 106 21 a a DT cord-009380-5uptbat3 106 22 firm firm JJ cord-009380-5uptbat3 106 23 cause cause NN cord-009380-5uptbat3 106 24 and and CC cord-009380-5uptbat3 106 25 effect effect NN cord-009380-5uptbat3 106 26 of of IN cord-009380-5uptbat3 106 27 the the DT cord-009380-5uptbat3 106 28 disease disease NN cord-009380-5uptbat3 107 1 ( ( -LRB- cord-009380-5uptbat3 107 2 Bryan Bryan NNP cord-009380-5uptbat3 107 3 et et NNP cord-009380-5uptbat3 107 4 al al NNP cord-009380-5uptbat3 107 5 . . NNP cord-009380-5uptbat3 107 6 , , , cord-009380-5uptbat3 107 7 1994 1994 CD cord-009380-5uptbat3 107 8 ; ; : cord-009380-5uptbat3 107 9 Holtzman Holtzman NNP cord-009380-5uptbat3 107 10 et et NNP cord-009380-5uptbat3 107 11 al al NNP cord-009380-5uptbat3 107 12 . . NNP cord-009380-5uptbat3 107 13 , , , cord-009380-5uptbat3 107 14 1997 1997 CD cord-009380-5uptbat3 107 15 ; ; . cord-009380-5uptbat3 108 1 Hoet Hoet NNP cord-009380-5uptbat3 108 2 and and CC cord-009380-5uptbat3 108 3 Haufroid Haufroid NNP cord-009380-5uptbat3 108 4 , , , cord-009380-5uptbat3 108 5 1997 1997 CD cord-009380-5uptbat3 108 6 ; ; : cord-009380-5uptbat3 108 7 Lipstich Lipstich NNP cord-009380-5uptbat3 108 8 et et NNP cord-009380-5uptbat3 108 9 al al NNP cord-009380-5uptbat3 108 10 . . NNP cord-009380-5uptbat3 108 11 , , , cord-009380-5uptbat3 108 12 1996 1996 CD cord-009380-5uptbat3 108 13 ; ; : cord-009380-5uptbat3 108 14 McDade McDade NNP cord-009380-5uptbat3 108 15 and and CC cord-009380-5uptbat3 108 16 Anderson Anderson NNP cord-009380-5uptbat3 108 17 , , , cord-009380-5uptbat3 108 18 1996 1996 CD cord-009380-5uptbat3 108 19 ; ; : cord-009380-5uptbat3 108 20 Poland Poland NNP cord-009380-5uptbat3 108 21 et et NNP cord-009380-5uptbat3 108 22 al al NNP cord-009380-5uptbat3 108 23 . . NNP cord-009380-5uptbat3 108 24 , , , cord-009380-5uptbat3 108 25 1996 1996 CD cord-009380-5uptbat3 108 26 ) ) -RRB- cord-009380-5uptbat3 108 27 . . . cord-009380-5uptbat3 109 1 1 1 LS cord-009380-5uptbat3 109 2 . . . cord-009380-5uptbat3 110 1 Is be VBZ cord-009380-5uptbat3 110 2 the the DT cord-009380-5uptbat3 110 3 infection infection NN cord-009380-5uptbat3 111 1 and/or and/or CC cord-009380-5uptbat3 111 2 disease disease NN cord-009380-5uptbat3 111 3 of of IN cord-009380-5uptbat3 111 4 economic economic JJ cord-009380-5uptbat3 111 5 concern concern NN cord-009380-5uptbat3 111 6 ? ? . cord-009380-5uptbat3 112 1 2 2 LS cord-009380-5uptbat3 112 2 . . . cord-009380-5uptbat3 113 1 Is be VBZ cord-009380-5uptbat3 113 2 the the DT cord-009380-5uptbat3 113 3 infection infection NN cord-009380-5uptbat3 114 1 and/or and/or CC cord-009380-5uptbat3 114 2 disease disease NN cord-009380-5uptbat3 114 3 of of IN cord-009380-5uptbat3 114 4 zoonotic zoonotic JJ cord-009380-5uptbat3 114 5 concern concern NN cord-009380-5uptbat3 114 6 ? ? . cord-009380-5uptbat3 115 1 3 3 LS cord-009380-5uptbat3 115 2 . . . cord-009380-5uptbat3 116 1 Where where WRB cord-009380-5uptbat3 116 2 is be VBZ cord-009380-5uptbat3 116 3 the the DT cord-009380-5uptbat3 116 4 microbial microbial JJ cord-009380-5uptbat3 116 5 agent agent NN cord-009380-5uptbat3 116 6 when when WRB cord-009380-5uptbat3 116 7 not not RB cord-009380-5uptbat3 116 8 causing cause VBG cord-009380-5uptbat3 116 9 disease disease NN cord-009380-5uptbat3 116 10 ( ( -LRB- cord-009380-5uptbat3 116 11 microbial microbial JJ cord-009380-5uptbat3 116 12 ecology ecology NN cord-009380-5uptbat3 116 13 ) ) -RRB- cord-009380-5uptbat3 116 14 ? ? . cord-009380-5uptbat3 117 1 4 4 LS cord-009380-5uptbat3 117 2 . . . cord-009380-5uptbat3 118 1 What what WP cord-009380-5uptbat3 118 2 are be VBP cord-009380-5uptbat3 118 3 the the DT cord-009380-5uptbat3 118 4 contributing contribute VBG cord-009380-5uptbat3 118 5 factors factor NNS cord-009380-5uptbat3 118 6 to to IN cord-009380-5uptbat3 118 7 the the DT cord-009380-5uptbat3 118 8 infection infection NN cord-009380-5uptbat3 118 9 and/or and/or CC cord-009380-5uptbat3 118 10 disease disease NN cord-009380-5uptbat3 118 11 process process NN cord-009380-5uptbat3 118 12 ? ? . cord-009380-5uptbat3 119 1 5 5 LS cord-009380-5uptbat3 119 2 . . . cord-009380-5uptbat3 120 1 What what WDT cord-009380-5uptbat3 120 2 factors factor NNS cord-009380-5uptbat3 120 3 can can MD cord-009380-5uptbat3 120 4 animal animal NN cord-009380-5uptbat3 120 5 owners owner NNS cord-009380-5uptbat3 120 6 / / SYM cord-009380-5uptbat3 120 7 veterinarians veterinarian NNS cord-009380-5uptbat3 120 8 / / SYM cord-009380-5uptbat3 120 9 public public JJ cord-009380-5uptbat3 120 10 health health NN cord-009380-5uptbat3 120 11 personnel personnel NNS cord-009380-5uptbat3 120 12 control control NN cord-009380-5uptbat3 120 13 to to TO cord-009380-5uptbat3 120 14 minimize minimize VB cord-009380-5uptbat3 120 15 or or CC cord-009380-5uptbat3 120 16 eliminate eliminate VB cord-009380-5uptbat3 120 17 the the DT cord-009380-5uptbat3 120 18 risk risk NN cord-009380-5uptbat3 120 19 of of IN cord-009380-5uptbat3 120 20 infection infection NN cord-009380-5uptbat3 120 21 / / SYM cord-009380-5uptbat3 120 22 disease disease NN cord-009380-5uptbat3 120 23 process process NN cord-009380-5uptbat3 120 24 ? ? . cord-009380-5uptbat3 120 25 _SP cord-009380-5uptbat3 121 1 TABLE table NN cord-009380-5uptbat3 121 2 III iii CD cord-009380-5uptbat3 121 3 immune immune JJ cord-009380-5uptbat3 121 4 function function NN cord-009380-5uptbat3 121 5 ( ( -LRB- cord-009380-5uptbat3 121 6 immune immune JJ cord-009380-5uptbat3 121 7 competence competence NN cord-009380-5uptbat3 121 8 ) ) -RRB- cord-009380-5uptbat3 121 9 , , , cord-009380-5uptbat3 121 10 ( ( -LRB- cord-009380-5uptbat3 121 11 2 2 LS cord-009380-5uptbat3 121 12 ) ) -RRB- cord-009380-5uptbat3 121 13 assays assay NNS cord-009380-5uptbat3 122 1 to to TO cord-009380-5uptbat3 122 2 monitor monitor VB cord-009380-5uptbat3 123 1 genetic genetic JJ cord-009380-5uptbat3 123 2 resistance resistance NN cord-009380-5uptbat3 123 3 / / SYM cord-009380-5uptbat3 123 4 susceptibility susceptibility NN cord-009380-5uptbat3 123 5 , , , cord-009380-5uptbat3 123 6 ( ( -LRB- cord-009380-5uptbat3 123 7 3 3 LS cord-009380-5uptbat3 123 8 ) ) -RRB- cord-009380-5uptbat3 123 9 assays assay NNS cord-009380-5uptbat3 123 10 to to TO cord-009380-5uptbat3 123 11 monitor monitor VB cord-009380-5uptbat3 123 12 infections infection NNS cord-009380-5uptbat3 123 13 , , , cord-009380-5uptbat3 123 14 ( ( -LRB- cord-009380-5uptbat3 123 15 4 4 LS cord-009380-5uptbat3 123 16 ) ) -RRB- cord-009380-5uptbat3 123 17 assays assay NNS cord-009380-5uptbat3 123 18 to to TO cord-009380-5uptbat3 123 19 diagnose diagnose VB cord-009380-5uptbat3 123 20 disease disease NN cord-009380-5uptbat3 123 21 and and CC cord-009380-5uptbat3 123 22 monitor monitor VB cord-009380-5uptbat3 123 23 response response NN cord-009380-5uptbat3 123 24 to to IN cord-009380-5uptbat3 123 25 treatment treatment NN cord-009380-5uptbat3 123 26 , , , cord-009380-5uptbat3 123 27 and and CC cord-009380-5uptbat3 123 28 ( ( -LRB- cord-009380-5uptbat3 123 29 5 5 LS cord-009380-5uptbat3 123 30 ) ) -RRB- cord-009380-5uptbat3 123 31 assays assay NNS cord-009380-5uptbat3 123 32 to to TO cord-009380-5uptbat3 123 33 track track VB cord-009380-5uptbat3 123 34 emerging emerge VBG cord-009380-5uptbat3 123 35 infections infection NNS cord-009380-5uptbat3 123 36 . . . cord-009380-5uptbat3 124 1 As as IN cord-009380-5uptbat3 124 2 infectious infectious JJ cord-009380-5uptbat3 124 3 agents agent NNS cord-009380-5uptbat3 124 4 continue continue VBP cord-009380-5uptbat3 124 5 to to TO cord-009380-5uptbat3 124 6 evolve evolve VB cord-009380-5uptbat3 124 7 , , , cord-009380-5uptbat3 124 8 disease disease NN cord-009380-5uptbat3 124 9 expression expression NN cord-009380-5uptbat3 124 10 will will MD cord-009380-5uptbat3 124 11 change change VB cord-009380-5uptbat3 124 12 , , , cord-009380-5uptbat3 124 13 resulting result VBG cord-009380-5uptbat3 124 14 in in IN cord-009380-5uptbat3 124 15 the the DT cord-009380-5uptbat3 124 16 necessity necessity NN cord-009380-5uptbat3 124 17 to to TO cord-009380-5uptbat3 124 18 develop develop VB cord-009380-5uptbat3 124 19 new new JJ cord-009380-5uptbat3 124 20 diagnostic diagnostic JJ cord-009380-5uptbat3 124 21 assays assay NNS cord-009380-5uptbat3 124 22 ( ( -LRB- cord-009380-5uptbat3 124 23 Susser Susser NNP cord-009380-5uptbat3 124 24 and and CC cord-009380-5uptbat3 124 25 Susser Susser NNP cord-009380-5uptbat3 124 26 , , , cord-009380-5uptbat3 124 27 1996b 1996b CD cord-009380-5uptbat3 124 28 ; ; : cord-009380-5uptbat3 124 29 Wilson Wilson NNP cord-009380-5uptbat3 124 30 , , , cord-009380-5uptbat3 124 31 1994 1994 CD cord-009380-5uptbat3 124 32 ) ) -RRB- cord-009380-5uptbat3 124 33 . . . cord-009380-5uptbat3 125 1 Nucleic nucleic JJ cord-009380-5uptbat3 125 2 Acid acid NN cord-009380-5uptbat3 125 3 Amplification amplification NN cord-009380-5uptbat3 125 4 Technologies Technologies NNPS cord-009380-5uptbat3 125 5 : : : cord-009380-5uptbat3 125 6 Application application NN cord-009380-5uptbat3 125 7 to to IN cord-009380-5uptbat3 125 8 Disease Disease NNP cord-009380-5uptbat3 125 9 Diagnosis Diagnosis NNP cord-009380-5uptbat3 125 10 Molecular Molecular NNP cord-009380-5uptbat3 125 11 diagnostics diagnostic NNS cord-009380-5uptbat3 125 12 for for IN cord-009380-5uptbat3 125 13 dairy dairy NN cord-009380-5uptbat3 125 14 - - HYPH cord-009380-5uptbat3 125 15 borne bear VBN cord-009380-5uptbat3 125 16 pathogens pathogen NNS cord-009380-5uptbat3 126 1 Emerging emerge VBG cord-009380-5uptbat3 126 2 infectious infectious JJ cord-009380-5uptbat3 126 3 diseases disease NNS cord-009380-5uptbat3 126 4 in in IN cord-009380-5uptbat3 126 5 the the DT cord-009380-5uptbat3 126 6 United United NNP cord-009380-5uptbat3 126 7 States States NNP cord-009380-5uptbat3 126 8 : : : cord-009380-5uptbat3 126 9 improved improve VBN cord-009380-5uptbat3 126 10 surveillance surveillance NN cord-009380-5uptbat3 126 11 , , , cord-009380-5uptbat3 126 12 a a DT cord-009380-5uptbat3 126 13 requisite requisite NN cord-009380-5uptbat3 126 14 for for IN cord-009380-5uptbat3 126 15 prevention prevention NN cord-009380-5uptbat3 126 16 Detection detection NN cord-009380-5uptbat3 126 17 of of IN cord-009380-5uptbat3 126 18 canine canine JJ cord-009380-5uptbat3 126 19 herpesvirus herpesvirus NN cord-009380-5uptbat3 126 20 1 1 CD cord-009380-5uptbat3 126 21 in in IN cord-009380-5uptbat3 126 22 a a DT cord-009380-5uptbat3 126 23 wide wide JJ cord-009380-5uptbat3 126 24 range range NN cord-009380-5uptbat3 126 25 of of IN cord-009380-5uptbat3 126 26 tissues tissue NNS cord-009380-5uptbat3 126 27 using use VBG cord-009380-5uptbat3 126 28 polymerase polymerase NN cord-009380-5uptbat3 126 29 chain chain NN cord-009380-5uptbat3 126 30 reaction reaction NN cord-009380-5uptbat3 126 31 Paratuberculosis Paratuberculosis NNP cord-009380-5uptbat3 126 32 and and CC cord-009380-5uptbat3 126 33 molecular molecular JJ cord-009380-5uptbat3 126 34 biology biology NN cord-009380-5uptbat3 127 1 Quantitative quantitative JJ cord-009380-5uptbat3 127 2 molecular molecular JJ cord-009380-5uptbat3 127 3 methods method NNS cord-009380-5uptbat3 127 4 in in IN cord-009380-5uptbat3 127 5 virology virology NN cord-009380-5uptbat3 127 6 Anatomy anatomy NN cord-009380-5uptbat3 127 7 of of IN cord-009380-5uptbat3 127 8 viral viral JJ cord-009380-5uptbat3 127 9 persistence persistence NN cord-009380-5uptbat3 127 10 : : : cord-009380-5uptbat3 127 11 mechanisms mechanism NNS cord-009380-5uptbat3 127 12 of of IN cord-009380-5uptbat3 127 13 persistence persistence NN cord-009380-5uptbat3 127 14 and and CC cord-009380-5uptbat3 127 15 associated associated JJ cord-009380-5uptbat3 127 16 disease disease NN cord-009380-5uptbat3 127 17 Status status NN cord-009380-5uptbat3 127 18 of of IN cord-009380-5uptbat3 127 19 bovine bovine JJ cord-009380-5uptbat3 127 20 tuberculosis tuberculosis NN cord-009380-5uptbat3 127 21 in in IN cord-009380-5uptbat3 127 22 North North NNP cord-009380-5uptbat3 127 23 America America NNP cord-009380-5uptbat3 127 24 Case Case NNP cord-009380-5uptbat3 127 25 control control NN cord-009380-5uptbat3 127 26 study study NN cord-009380-5uptbat3 127 27 of of IN cord-009380-5uptbat3 127 28 multiple multiple JJ cord-009380-5uptbat3 127 29 - - HYPH cord-009380-5uptbat3 127 30 resistant resistant JJ cord-009380-5uptbat3 127 31 Salmonella Salmonella NNP cord-009380-5uptbat3 127 32 typhimurium typhimurium NN cord-009380-5uptbat3 128 1 DT104 DT104 NNP cord-009380-5uptbat3 128 2 infections infection NNS cord-009380-5uptbat3 128 3 in in IN cord-009380-5uptbat3 128 4 cattle cattle NNS cord-009380-5uptbat3 128 5 in in IN cord-009380-5uptbat3 128 6 Great Great NNP cord-009380-5uptbat3 128 7 Britain Britain NNP cord-009380-5uptbat3 128 8 Laboratory Laboratory NNP cord-009380-5uptbat3 128 9 diagnosis diagnosis NN cord-009380-5uptbat3 128 10 of of IN cord-009380-5uptbat3 128 11 viral viral JJ cord-009380-5uptbat3 128 12 and and CC cord-009380-5uptbat3 128 13 rickettsial rickettsial JJ cord-009380-5uptbat3 128 14 infections infection NNS cord-009380-5uptbat3 128 15 Laboratory Laboratory NNP cord-009380-5uptbat3 128 16 diagnosis diagnosis NN cord-009380-5uptbat3 128 17 of of IN cord-009380-5uptbat3 128 18 viral viral JJ cord-009380-5uptbat3 128 19 and and CC cord-009380-5uptbat3 128 20 rickettsial rickettsial JJ cord-009380-5uptbat3 128 21 infections infection NNS cord-009380-5uptbat3 129 1 Laboratory laboratory NN cord-009380-5uptbat3 129 2 diagnostic diagnostic JJ cord-009380-5uptbat3 129 3 tests test NNS cord-009380-5uptbat3 129 4 for for IN cord-009380-5uptbat3 129 5 retroviral retroviral JJ cord-009380-5uptbat3 129 6 infections infection NNS cord-009380-5uptbat3 129 7 in in IN cord-009380-5uptbat3 129 8 dairy dairy NN cord-009380-5uptbat3 129 9 and and CC cord-009380-5uptbat3 129 10 beef beef NN cord-009380-5uptbat3 129 11 cattle cattle NNS cord-009380-5uptbat3 129 12 Feline feline JJ cord-009380-5uptbat3 129 13 infectious infectious JJ cord-009380-5uptbat3 129 14 peritonitis peritonitis NN cord-009380-5uptbat3 129 15 EZ EZ NNP cord-009380-5uptbat3 129 16 coli coli VBZ cord-009380-5uptbat3 129 17 rapid rapid JJ cord-009380-5uptbat3 129 18 detection detection NN cord-009380-5uptbat3 129 19 system system NN cord-009380-5uptbat3 129 20 : : : cord-009380-5uptbat3 129 21 A a DT cord-009380-5uptbat3 129 22 rapid rapid JJ cord-009380-5uptbat3 129 23 method method NN cord-009380-5uptbat3 129 24 for for IN cord-009380-5uptbat3 129 25 the the DT cord-009380-5uptbat3 129 26 detection detection NN cord-009380-5uptbat3 129 27 of of IN cord-009380-5uptbat3 129 28 Escherichia Escherichia NNP cord-009380-5uptbat3 129 29 coli coli NNS cord-009380-5uptbat3 129 30 O157 O157 NNP cord-009380-5uptbat3 129 31 in in IN cord-009380-5uptbat3 129 32 meat meat NN cord-009380-5uptbat3 129 33 and and CC cord-009380-5uptbat3 129 34 other other JJ cord-009380-5uptbat3 129 35 foods food NNS cord-009380-5uptbat3 129 36 Risk risk NN cord-009380-5uptbat3 129 37 factors factor NNS cord-009380-5uptbat3 129 38 for for IN cord-009380-5uptbat3 129 39 feline feline JJ cord-009380-5uptbat3 129 40 infectious infectious JJ cord-009380-5uptbat3 129 41 peritonitis peritonitis NN cord-009380-5uptbat3 129 42 among among IN cord-009380-5uptbat3 129 43 cats cat NNS cord-009380-5uptbat3 129 44 in in IN cord-009380-5uptbat3 129 45 multiple multiple JJ cord-009380-5uptbat3 129 46 - - HYPH cord-009380-5uptbat3 129 47 cat cat NN cord-009380-5uptbat3 129 48 environments environment NNS cord-009380-5uptbat3 129 49 with with IN cord-009380-5uptbat3 129 50 endemic endemic JJ cord-009380-5uptbat3 129 51 feline feline JJ cord-009380-5uptbat3 129 52 enteric enteric JJ cord-009380-5uptbat3 129 53 coronavirus coronavirus NN cord-009380-5uptbat3 129 54 Sequence sequence NN cord-009380-5uptbat3 129 55 - - HYPH cord-009380-5uptbat3 129 56 based base VBN cord-009380-5uptbat3 129 57 identification identification NN cord-009380-5uptbat3 129 58 of of IN cord-009380-5uptbat3 129 59 microbial microbial JJ cord-009380-5uptbat3 129 60 pathogens pathogen NNS cord-009380-5uptbat3 129 61 : : : cord-009380-5uptbat3 129 62 A a DT cord-009380-5uptbat3 129 63 reconsideration reconsideration NN cord-009380-5uptbat3 129 64 of of IN cord-009380-5uptbat3 129 65 Koch Koch NNP cord-009380-5uptbat3 129 66 's 's POS cord-009380-5uptbat3 129 67 Postulates Postulates NNPS cord-009380-5uptbat3 129 68 Resistance Resistance NNP cord-009380-5uptbat3 129 69 of of IN cord-009380-5uptbat3 129 70 livestock livestock NN cord-009380-5uptbat3 129 71 to to IN cord-009380-5uptbat3 129 72 viruses virus NNS cord-009380-5uptbat3 129 73 : : : cord-009380-5uptbat3 129 74 Mechanisms mechanism NNS cord-009380-5uptbat3 129 75 and and CC cord-009380-5uptbat3 129 76 strategies strategy NNS cord-009380-5uptbat3 129 77 for for IN cord-009380-5uptbat3 129 78 genetic genetic JJ cord-009380-5uptbat3 129 79 engineering engineering NN cord-009380-5uptbat3 129 80 Detection Detection NNP cord-009380-5uptbat3 129 81 of of IN cord-009380-5uptbat3 129 82 Chlamydia Chlamydia NNP cord-009380-5uptbat3 129 83 psittici psittici NN cord-009380-5uptbat3 129 84 DNA dna NN cord-009380-5uptbat3 129 85 in in IN cord-009380-5uptbat3 129 86 avian avian JJ cord-009380-5uptbat3 129 87 clinical clinical JJ cord-009380-5uptbat3 129 88 samples sample NNS cord-009380-5uptbat3 129 89 by by IN cord-009380-5uptbat3 129 90 polymerase polymerase NN cord-009380-5uptbat3 129 91 chain chain NN cord-009380-5uptbat3 129 92 reaction reaction NN cord-009380-5uptbat3 129 93 Biological Biological NNP cord-009380-5uptbat3 129 94 monitoring monitoring NN cord-009380-5uptbat3 129 95 : : : cord-009380-5uptbat3 130 1 State state NN cord-009380-5uptbat3 130 2 of of IN cord-009380-5uptbat3 130 3 the the DT cord-009380-5uptbat3 130 4 art art NN cord-009380-5uptbat3 130 5 Predictive predictive JJ cord-009380-5uptbat3 130 6 genetic genetic JJ cord-009380-5uptbat3 130 7 testing testing NN cord-009380-5uptbat3 130 8 : : : cord-009380-5uptbat3 130 9 From from IN cord-009380-5uptbat3 130 10 basic basic JJ cord-009380-5uptbat3 130 11 research research NN cord-009380-5uptbat3 130 12 to to IN cord-009380-5uptbat3 130 13 clinical clinical JJ cord-009380-5uptbat3 130 14 practice practice NN cord-009380-5uptbat3 131 1 The the DT cord-009380-5uptbat3 131 2 use use NN cord-009380-5uptbat3 131 3 of of IN cord-009380-5uptbat3 131 4 a a DT cord-009380-5uptbat3 131 5 mass mass JJ cord-009380-5uptbat3 131 6 - - HYPH cord-009380-5uptbat3 131 7 action action NN cord-009380-5uptbat3 131 8 model model NN cord-009380-5uptbat3 131 9 to to TO cord-009380-5uptbat3 131 10 validate validate VB cord-009380-5uptbat3 131 11 the the DT cord-009380-5uptbat3 131 12 output output NN cord-009380-5uptbat3 131 13 from from IN cord-009380-5uptbat3 131 14 a a DT cord-009380-5uptbat3 131 15 stochastic stochastic JJ cord-009380-5uptbat3 131 16 simulation simulation NN cord-009380-5uptbat3 131 17 model model NN cord-009380-5uptbat3 131 18 of of IN cord-009380-5uptbat3 131 19 bovine bovine JJ cord-009380-5uptbat3 131 20 viral viral JJ cord-009380-5uptbat3 131 21 diarrhea diarrhea NN cord-009380-5uptbat3 131 22 virus virus NN cord-009380-5uptbat3 131 23 spread spread VBD cord-009380-5uptbat3 131 24 in in IN cord-009380-5uptbat3 131 25 a a DT cord-009380-5uptbat3 131 26 closed closed JJ cord-009380-5uptbat3 131 27 dairy dairy NN cord-009380-5uptbat3 131 28 herd herd NN cord-009380-5uptbat3 131 29 . . . cord-009380-5uptbat3 132 1 Prey Prey NNP cord-009380-5uptbat3 132 2 Principles Principles NNPS cord-009380-5uptbat3 132 3 of of IN cord-009380-5uptbat3 132 4 validation validation NN cord-009380-5uptbat3 132 5 of of IN cord-009380-5uptbat3 132 6 diagnostic diagnostic JJ cord-009380-5uptbat3 132 7 assays assay NNS cord-009380-5uptbat3 132 8 for for IN cord-009380-5uptbat3 132 9 infectious infectious JJ cord-009380-5uptbat3 132 10 diseases disease NNS cord-009380-5uptbat3 132 11 Assessing assess VBG cord-009380-5uptbat3 132 12 the the DT cord-009380-5uptbat3 132 13 validity validity NN cord-009380-5uptbat3 132 14 of of IN cord-009380-5uptbat3 132 15 serodiagnostic serodiagnostic JJ cord-009380-5uptbat3 132 16 test test NN cord-009380-5uptbat3 132 17 results result NNS cord-009380-5uptbat3 132 18 . . . cord-009380-5uptbat3 133 1 Semin Semin NNP cord-009380-5uptbat3 133 2 Laboratory Laboratory NNP cord-009380-5uptbat3 133 3 diagnostic diagnostic JJ cord-009380-5uptbat3 133 4 tests test NNS cord-009380-5uptbat3 133 5 for for IN cord-009380-5uptbat3 133 6 retrovirus retrovirus NN cord-009380-5uptbat3 133 7 infections infection NNS cord-009380-5uptbat3 133 8 of of IN cord-009380-5uptbat3 133 9 small small JJ cord-009380-5uptbat3 133 10 ruminants ruminant NNS cord-009380-5uptbat3 133 11 Detection detection NN cord-009380-5uptbat3 133 12 of of IN cord-009380-5uptbat3 133 13 equine equine JJ cord-009380-5uptbat3 133 14 infectious infectious JJ cord-009380-5uptbat3 133 15 anemia anemia NN cord-009380-5uptbat3 133 16 viral viral JJ cord-009380-5uptbat3 133 17 RNA RNA NNP cord-009380-5uptbat3 133 18 in in IN cord-009380-5uptbat3 133 19 plasma plasma NN cord-009380-5uptbat3 133 20 samples sample NNS cord-009380-5uptbat3 133 21 from from IN cord-009380-5uptbat3 133 22 recently recently RB cord-009380-5uptbat3 133 23 infected infect VBN cord-009380-5uptbat3 133 24 and and CC cord-009380-5uptbat3 133 25 long long JJ cord-009380-5uptbat3 133 26 - - HYPH cord-009380-5uptbat3 133 27 term term NN cord-009380-5uptbat3 133 28 inapparent inapparent JJ cord-009380-5uptbat3 133 29 carrier carrier NN cord-009380-5uptbat3 133 30 animals animal NNS cord-009380-5uptbat3 133 31 by by IN cord-009380-5uptbat3 133 32 PCR PCR NNP cord-009380-5uptbat3 134 1 The the DT cord-009380-5uptbat3 134 2 evolution evolution NN cord-009380-5uptbat3 134 3 of of IN cord-009380-5uptbat3 134 4 virulence virulence NN cord-009380-5uptbat3 134 5 in in IN cord-009380-5uptbat3 134 6 pathogens pathogen NNS cord-009380-5uptbat3 134 7 with with IN cord-009380-5uptbat3 134 8 vertical vertical JJ cord-009380-5uptbat3 134 9 and and CC cord-009380-5uptbat3 134 10 horizontal horizontal JJ cord-009380-5uptbat3 134 11 transmission transmission NN cord-009380-5uptbat3 134 12 Genetic genetic JJ cord-009380-5uptbat3 134 13 control control NN cord-009380-5uptbat3 134 14 of of IN cord-009380-5uptbat3 134 15 host host NN cord-009380-5uptbat3 134 16 resistance resistance NN cord-009380-5uptbat3 134 17 to to IN cord-009380-5uptbat3 134 18 infection infection NN cord-009380-5uptbat3 134 19 Rapid Rapid NNP cord-009380-5uptbat3 134 20 detection detection NN cord-009380-5uptbat3 134 21 of of IN cord-009380-5uptbat3 134 22 bovine bovine JJ cord-009380-5uptbat3 134 23 herpesvirus herpesvirus NN cord-009380-5uptbat3 134 24 1 1 CD cord-009380-5uptbat3 134 25 in in IN cord-009380-5uptbat3 134 26 the the DT cord-009380-5uptbat3 134 27 semen semen NN cord-009380-5uptbat3 134 28 of of IN cord-009380-5uptbat3 134 29 infected infected JJ cord-009380-5uptbat3 134 30 bulls bull NNS cord-009380-5uptbat3 134 31 by by IN cord-009380-5uptbat3 134 32 a a DT cord-009380-5uptbat3 134 33 nested nested JJ cord-009380-5uptbat3 134 34 polymerase polymerase NN cord-009380-5uptbat3 134 35 chain chain NN cord-009380-5uptbat3 134 36 reaction reaction NN cord-009380-5uptbat3 134 37 assay assay NN cord-009380-5uptbat3 134 38 Molecular molecular JJ cord-009380-5uptbat3 134 39 epidemiology epidemiology NN cord-009380-5uptbat3 134 40 : : : cord-009380-5uptbat3 134 41 Applications application NNS cord-009380-5uptbat3 134 42 of of IN cord-009380-5uptbat3 134 43 nucleic nucleic JJ cord-009380-5uptbat3 134 44 acid acid NN cord-009380-5uptbat3 134 45 amplification amplification NN cord-009380-5uptbat3 134 46 and and CC cord-009380-5uptbat3 134 47 sequence sequence NN cord-009380-5uptbat3 134 48 analysis analysis NN cord-009380-5uptbat3 134 49 Diagnosing diagnose VBG cord-009380-5uptbat3 134 50 emerging emerge VBG cord-009380-5uptbat3 134 51 bacterial bacterial JJ cord-009380-5uptbat3 134 52 infections infection NNS cord-009380-5uptbat3 134 53 : : : cord-009380-5uptbat3 134 54 Salmonellosis salmonellosis NN cord-009380-5uptbat3 134 55 , , , cord-009380-5uptbat3 134 56 Campylobacteriosis Campylobacteriosis NNP cord-009380-5uptbat3 134 57 , , , cord-009380-5uptbat3 134 58 Clostridial Clostridial NNP cord-009380-5uptbat3 134 59 toxicosis toxicosis NN cord-009380-5uptbat3 134 60 , , , cord-009380-5uptbat3 134 61 and and CC cord-009380-5uptbat3 134 62 Helicobacteriosis Helicobacteriosis NNP cord-009380-5uptbat3 134 63 . . . cord-009380-5uptbat3 135 1 Semin Semin NNP cord-009380-5uptbat3 136 1 The the DT cord-009380-5uptbat3 136 2 epidemiology epidemiology NN cord-009380-5uptbat3 136 3 of of IN cord-009380-5uptbat3 136 4 Mycobacterium Mycobacterium NNP cord-009380-5uptbat3 136 5 bovis bovis NN cord-009380-5uptbat3 136 6 infection infection NN cord-009380-5uptbat3 136 7 in in IN cord-009380-5uptbat3 136 8 animals animal NNS cord-009380-5uptbat3 136 9 and and CC cord-009380-5uptbat3 136 10 man man NN cord-009380-5uptbat3 136 11 : : : cord-009380-5uptbat3 136 12 A a DT cord-009380-5uptbat3 136 13 review review NN cord-009380-5uptbat3 136 14 PrP prp NN cord-009380-5uptbat3 136 15 genotypes genotype NNS cord-009380-5uptbat3 136 16 and and CC cord-009380-5uptbat3 136 17 experimental experimental JJ cord-009380-5uptbat3 136 18 scrapie scrapie NN cord-009380-5uptbat3 136 19 in in IN cord-009380-5uptbat3 136 20 orally orally RB cord-009380-5uptbat3 136 21 inoculated inoculate VBN cord-009380-5uptbat3 136 22 Suffolk Suffolk NNP cord-009380-5uptbat3 136 23 sheep sheep NNS cord-009380-5uptbat3 136 24 in in IN cord-009380-5uptbat3 136 25 the the DT cord-009380-5uptbat3 136 26 United United NNP cord-009380-5uptbat3 136 27 States States NNP cord-009380-5uptbat3 136 28 Two two CD cord-009380-5uptbat3 136 29 related related JJ cord-009380-5uptbat3 136 30 strains strain NNS cord-009380-5uptbat3 136 31 of of IN cord-009380-5uptbat3 136 32 feline feline JJ cord-009380-5uptbat3 136 33 infectious infectious JJ cord-009380-5uptbat3 136 34 peritonitis peritonitis NN cord-009380-5uptbat3 136 35 virus virus NN cord-009380-5uptbat3 136 36 isolated isolate VBN cord-009380-5uptbat3 136 37 from from IN cord-009380-5uptbat3 136 38 immunocompromised immunocompromised JJ cord-009380-5uptbat3 136 39 cats cat NNS cord-009380-5uptbat3 136 40 infected infect VBN cord-009380-5uptbat3 136 41 with with IN cord-009380-5uptbat3 136 42 a a DT cord-009380-5uptbat3 136 43 feline feline JJ cord-009380-5uptbat3 136 44 enteric enteric JJ cord-009380-5uptbat3 136 45 coronavirus coronavirus NN cord-009380-5uptbat3 136 46 Rickettsioses Rickettsioses NNPS cord-009380-5uptbat3 136 47 as as IN cord-009380-5uptbat3 136 48 paradigms paradigm NNS cord-009380-5uptbat3 136 49 of of IN cord-009380-5uptbat3 136 50 new new JJ cord-009380-5uptbat3 136 51 or or CC cord-009380-5uptbat3 136 52 emerging emerge VBG cord-009380-5uptbat3 136 53 infectious infectious JJ cord-009380-5uptbat3 136 54 diseases disease NNS cord-009380-5uptbat3 136 55 Genotypic Genotypic NNP cord-009380-5uptbat3 136 56 methods method NNS cord-009380-5uptbat3 136 57 for for IN cord-009380-5uptbat3 136 58 microbiol microbiol NNP cord-009380-5uptbat3 136 59 identification identification NN cord-009380-5uptbat3 136 60 Detection Detection NNP cord-009380-5uptbat3 136 61 of of IN cord-009380-5uptbat3 136 62 animal animal NN cord-009380-5uptbat3 136 63 pathogens pathogen NNS cord-009380-5uptbat3 136 64 by by IN cord-009380-5uptbat3 136 65 using use VBG cord-009380-5uptbat3 136 66 the the DT cord-009380-5uptbat3 136 67 polymerase polymerase NN cord-009380-5uptbat3 136 68 chain chain NN cord-009380-5uptbat3 136 69 reaction reaction NN cord-009380-5uptbat3 136 70 ( ( -LRB- cord-009380-5uptbat3 136 71 PCR PCR NNP cord-009380-5uptbat3 136 72 ) ) -RRB- cord-009380-5uptbat3 136 73 Factors Factors NNP cord-009380-5uptbat3 136 74 in in IN cord-009380-5uptbat3 136 75 the the DT cord-009380-5uptbat3 136 76 Emergence Emergence NNP cord-009380-5uptbat3 136 77 of of IN cord-009380-5uptbat3 136 78 Arbivirus Arbivirus NNP cord-009380-5uptbat3 136 79 Diseases Diseases NNPS cord-009380-5uptbat3 136 80 Escherichia Escherichia NNP cord-009380-5uptbat3 136 81 coli coli NNS cord-009380-5uptbat3 136 82 O157 O157 NNP cord-009380-5uptbat3 136 83 : : : cord-009380-5uptbat3 137 1 H7 H7 NNP cord-009380-5uptbat3 137 2 diarrhea diarrhea NN cord-009380-5uptbat3 137 3 in in IN cord-009380-5uptbat3 137 4 the the DT cord-009380-5uptbat3 137 5 United United NNP cord-009380-5uptbat3 137 6 States States NNP cord-009380-5uptbat3 137 7 : : : cord-009380-5uptbat3 138 1 Clinical clinical JJ cord-009380-5uptbat3 138 2 and and CC cord-009380-5uptbat3 138 3 epidemiologic epidemiologic JJ cord-009380-5uptbat3 138 4 features feature VBZ cord-009380-5uptbat3 138 5 New new JJ cord-009380-5uptbat3 138 6 aspects aspect NNS cord-009380-5uptbat3 138 7 of of IN cord-009380-5uptbat3 138 8 rabies rabie NNS cord-009380-5uptbat3 138 9 with with IN cord-009380-5uptbat3 138 10 emphasis emphasis NN cord-009380-5uptbat3 138 11 on on IN cord-009380-5uptbat3 138 12 epidemiology epidemiology NN cord-009380-5uptbat3 138 13 , , , cord-009380-5uptbat3 138 14 diagnosis diagnosis NN cord-009380-5uptbat3 138 15 and and CC cord-009380-5uptbat3 138 16 prevention prevention NN cord-009380-5uptbat3 138 17 of of IN cord-009380-5uptbat3 138 18 the the DT cord-009380-5uptbat3 138 19 disease disease NN cord-009380-5uptbat3 138 20 in in IN cord-009380-5uptbat3 138 21 the the DT cord-009380-5uptbat3 138 22 United United NNP cord-009380-5uptbat3 138 23 States States NNP cord-009380-5uptbat3 138 24 Evaluation Evaluation NNP cord-009380-5uptbat3 138 25 of of IN cord-009380-5uptbat3 138 26 diagnostic diagnostic JJ cord-009380-5uptbat3 138 27 tests test NNS cord-009380-5uptbat3 138 28 Choosing choose VBG cord-009380-5uptbat3 138 29 a a DT cord-009380-5uptbat3 138 30 future future NN cord-009380-5uptbat3 138 31 for for IN cord-009380-5uptbat3 138 32 epidemiology epidemiology NN cord-009380-5uptbat3 138 33 : : : cord-009380-5uptbat3 139 1 I. I. NNP cord-009380-5uptbat3 139 2 Eras era NNS cord-009380-5uptbat3 139 3 and and CC cord-009380-5uptbat3 139 4 paradigms paradigm NNS cord-009380-5uptbat3 139 5 Choosing choose VBG cord-009380-5uptbat3 139 6 a a DT cord-009380-5uptbat3 139 7 future future NN cord-009380-5uptbat3 139 8 for for IN cord-009380-5uptbat3 139 9 epidemiology epidemiology NN cord-009380-5uptbat3 139 10 : : : cord-009380-5uptbat3 139 11 II II NNP cord-009380-5uptbat3 139 12 . . . cord-009380-5uptbat3 140 1 From from IN cord-009380-5uptbat3 140 2 black black JJ cord-009380-5uptbat3 140 3 box box NN cord-009380-5uptbat3 140 4 to to IN cord-009380-5uptbat3 140 5 chinese chinese JJ cord-009380-5uptbat3 140 6 boxes box NNS cord-009380-5uptbat3 140 7 and and CC cord-009380-5uptbat3 140 8 eco eco NN cord-009380-5uptbat3 140 9 - - HYPH cord-009380-5uptbat3 140 10 epidemiology epidemiology NN cord-009380-5uptbat3 140 11 Chromosome chromosome NN cord-009380-5uptbat3 140 12 rearrangement rearrangement NN cord-009380-5uptbat3 140 13 , , , cord-009380-5uptbat3 140 14 oncogene oncogene NN cord-009380-5uptbat3 140 15 activation activation NN cord-009380-5uptbat3 140 16 and and CC cord-009380-5uptbat3 140 17 other other JJ cord-009380-5uptbat3 140 18 clinical clinical JJ cord-009380-5uptbat3 140 19 events event NNS cord-009380-5uptbat3 140 20 in in IN cord-009380-5uptbat3 140 21 cancer cancer NN cord-009380-5uptbat3 140 22 . . . cord-009380-5uptbat3 141 1 Their -PRON- PRP$ cord-009380-5uptbat3 141 2 use use NN cord-009380-5uptbat3 141 3 in in IN cord-009380-5uptbat3 141 4 molecular molecular JJ cord-009380-5uptbat3 141 5 diagnostics diagnostic NNS cord-009380-5uptbat3 141 6 Disease Disease NNP cord-009380-5uptbat3 141 7 in in IN cord-009380-5uptbat3 141 8 evolution evolution NN cord-009380-5uptbat3 141 9 : : : cord-009380-5uptbat3 141 10 introduction introduction NN cord-009380-5uptbat3 141 11 Detection detection NN cord-009380-5uptbat3 141 12 of of IN cord-009380-5uptbat3 141 13 proviral proviral JJ cord-009380-5uptbat3 141 14 DNA dna NN cord-009380-5uptbat3 141 15 of of IN cord-009380-5uptbat3 141 16 bovine bovine JJ cord-009380-5uptbat3 141 17 leukemia leukemia NN cord-009380-5uptbat3 141 18 virus virus NN cord-009380-5uptbat3 141 19 in in IN cord-009380-5uptbat3 141 20 cattle cattle NNS cord-009380-5uptbat3 141 21 by by IN cord-009380-5uptbat3 141 22 a a DT cord-009380-5uptbat3 141 23 combination combination NN cord-009380-5uptbat3 141 24 of of IN cord-009380-5uptbat3 141 25 in in IN cord-009380-5uptbat3 141 26 situ situ NN cord-009380-5uptbat3 141 27 hybridization hybridization NN cord-009380-5uptbat3 141 28 and and CC cord-009380-5uptbat3 141 29 the the DT cord-009380-5uptbat3 141 30 polymerase polymerase NN cord-009380-5uptbat3 141 31 chain chain NN cord-009380-5uptbat3 141 32 reaction reaction NN cord-009380-5uptbat3 141 33 9 9 CD cord-009380-5uptbat3 142 1 No no DT cord-009380-5uptbat3 142 2 sale sale NN cord-009380-5uptbat3 142 3 9 9 CD cord-009380-5uptbat3 142 4 Public public JJ cord-009380-5uptbat3 142 5 health health NN cord-009380-5uptbat3 142 6 risk risk NN cord-009380-5uptbat3 142 7 9 9 CD cord-009380-5uptbat3 142 8 Early early JJ cord-009380-5uptbat3 142 9 cull cull NN cord-009380-5uptbat3 142 10 9 9 CD cord-009380-5uptbat3 142 11 Regulatory regulatory JJ cord-009380-5uptbat3 142 12 quarantine quarantine NN cord-009380-5uptbat3 142 13 9 9 CD cord-009380-5uptbat3 142 14 Shedding shedding NN cord-009380-5uptbat3 142 15 of of IN cord-009380-5uptbat3 142 16 microbial microbial JJ cord-009380-5uptbat3 142 17 agent agent NN cord-009380-5uptbat3 142 18 to to IN cord-009380-5uptbat3 142 19 susceptible susceptible JJ cord-009380-5uptbat3 142 20 animals animal NNS cord-009380-5uptbat3 142 21 in in IN cord-009380-5uptbat3 142 22 the the DT cord-009380-5uptbat3 142 23 population population NN cord-009380-5uptbat3 142 24 9 9 CD cord-009380-5uptbat3 142 25 Segregation segregation NN cord-009380-5uptbat3 142 26 of of IN cord-009380-5uptbat3 142 27 animal animal NN cord-009380-5uptbat3 142 28 9 9 CD cord-009380-5uptbat3 142 29 Euthanasia Euthanasia NNP cord-009380-5uptbat3 142 30 of of IN cord-009380-5uptbat3 142 31 animal(s)The animal(s)The NNP cord-009380-5uptbat3 142 32 future future NN cord-009380-5uptbat3 142 33 of of IN cord-009380-5uptbat3 142 34 veterinary veterinary JJ cord-009380-5uptbat3 142 35 diagnostics diagnostic NNS cord-009380-5uptbat3 142 36 is be VBZ cord-009380-5uptbat3 142 37 now now RB cord-009380-5uptbat3 142 38 . . . cord-009380-5uptbat3 143 1 There there EX cord-009380-5uptbat3 143 2 are be VBP cord-009380-5uptbat3 143 3 at at RB cord-009380-5uptbat3 143 4 least least JJS cord-009380-5uptbat3 143 5 five five CD cord-009380-5uptbat3 143 6 directions direction NNS cord-009380-5uptbat3 143 7 to to TO cord-009380-5uptbat3 143 8 be be VB cord-009380-5uptbat3 143 9 pursued pursue VBN cord-009380-5uptbat3 143 10 ( ( -LRB- cord-009380-5uptbat3 143 11 Table Table NNP cord-009380-5uptbat3 143 12 IV IV NNP cord-009380-5uptbat3 143 13 ) ) -RRB- cord-009380-5uptbat3 143 14 , , , cord-009380-5uptbat3 143 15 none none NN cord-009380-5uptbat3 143 16 of of IN cord-009380-5uptbat3 143 17 which which WDT cord-009380-5uptbat3 143 18 is be VBZ cord-009380-5uptbat3 143 19 new new JJ cord-009380-5uptbat3 143 20 , , , cord-009380-5uptbat3 143 21 but but CC cord-009380-5uptbat3 143 22 continuing continue VBG cord-009380-5uptbat3 143 23 to to TO cord-009380-5uptbat3 143 24 evolve evolve VB cord-009380-5uptbat3 143 25 as as IN cord-009380-5uptbat3 143 26 the the DT cord-009380-5uptbat3 143 27 needs need NNS cord-009380-5uptbat3 143 28 mandate mandate VBP cord-009380-5uptbat3 143 29 the the DT cord-009380-5uptbat3 143 30 detection detection NN cord-009380-5uptbat3 143 31 of of IN cord-009380-5uptbat3 143 32 infection infection NN cord-009380-5uptbat3 143 33 earlier early RBR cord-009380-5uptbat3 143 34 and and CC cord-009380-5uptbat3 143 35 the the DT cord-009380-5uptbat3 143 36 diagnosis diagnosis NN cord-009380-5uptbat3 143 37 of of IN cord-009380-5uptbat3 143 38 disease disease NN cord-009380-5uptbat3 143 39 at at IN cord-009380-5uptbat3 143 40 a a DT cord-009380-5uptbat3 143 41 manageable manageable JJ cord-009380-5uptbat3 143 42 stage stage NN cord-009380-5uptbat3 143 43 ( ( -LRB- cord-009380-5uptbat3 143 44 Wilson Wilson NNP cord-009380-5uptbat3 143 45 , , , cord-009380-5uptbat3 143 46 1994 1994 CD cord-009380-5uptbat3 143 47 ) ) -RRB- cord-009380-5uptbat3 143 48 . . . cord-009380-5uptbat3 144 1 These these DT cord-009380-5uptbat3 144 2 five five CD cord-009380-5uptbat3 144 3 directions direction NNS cord-009380-5uptbat3 144 4 are be VBP cord-009380-5uptbat3 144 5 the the DT cord-009380-5uptbat3 144 6 development development NN cord-009380-5uptbat3 144 7 of of IN cord-009380-5uptbat3 144 8 ( ( -LRB- cord-009380-5uptbat3 144 9 1 1 CD cord-009380-5uptbat3 144 10 ) ) -RRB- cord-009380-5uptbat3 144 11 assays assay NNS cord-009380-5uptbat3 144 12 to to TO cord-009380-5uptbat3 144 13 monitor monitor VB cord-009380-5uptbat3 144 14 1 1 CD cord-009380-5uptbat3 144 15 . . . cord-009380-5uptbat3 145 1 Assays assay NNS cord-009380-5uptbat3 145 2 to to TO cord-009380-5uptbat3 145 3 monitor monitor VB cord-009380-5uptbat3 145 4 immune immune JJ cord-009380-5uptbat3 145 5 function function NN cord-009380-5uptbat3 145 6 ( ( -LRB- cord-009380-5uptbat3 145 7 immune immune JJ cord-009380-5uptbat3 145 8 competence competence NN cord-009380-5uptbat3 145 9 ) ) -RRB- cord-009380-5uptbat3 146 1 9 9 CD cord-009380-5uptbat3 147 1 Foal foal NN cord-009380-5uptbat3 147 2 check check NN cord-009380-5uptbat3 147 3 9 9 CD cord-009380-5uptbat3 147 4 Calf calf NN cord-009380-5uptbat3 147 5 failure failure NN cord-009380-5uptbat3 147 6 of of IN cord-009380-5uptbat3 147 7 passive passive JJ cord-009380-5uptbat3 147 8 transfer transfer NN cord-009380-5uptbat3 148 1 9 9 CD cord-009380-5uptbat3 148 2 Llama Llama NNP cord-009380-5uptbat3 148 3 / / SYM cord-009380-5uptbat3 148 4 alpaca alpaca NN cord-009380-5uptbat3 148 5 immunoglobulin immunoglobulin NN cord-009380-5uptbat3 148 6 status status NN cord-009380-5uptbat3 148 7 9 9 CD cord-009380-5uptbat3 148 8 CMI CMI NNP cord-009380-5uptbat3 148 9 response response NN cord-009380-5uptbat3 148 10 2 2 CD cord-009380-5uptbat3 148 11 . . . cord-009380-5uptbat3 149 1 Assays assay NNS cord-009380-5uptbat3 149 2 to to TO cord-009380-5uptbat3 149 3 monitor monitor VB cord-009380-5uptbat3 149 4 genetic genetic JJ cord-009380-5uptbat3 149 5 resistance resistance NN cord-009380-5uptbat3 149 6 / / SYM cord-009380-5uptbat3 149 7 genetic genetic JJ cord-009380-5uptbat3 149 8 susceptibility susceptibility NN cord-009380-5uptbat3 149 9 9 9 CD cord-009380-5uptbat3 149 10 Cellular cellular JJ cord-009380-5uptbat3 149 11 receptors receptor NNS cord-009380-5uptbat3 149 12 9 9 CD cord-009380-5uptbat3 149 13 Cellular cellular JJ cord-009380-5uptbat3 149 14 oncogenes oncogene NNS cord-009380-5uptbat3 149 15 9 9 CD cord-009380-5uptbat3 149 16 Cellular cellular JJ cord-009380-5uptbat3 149 17 prion prion NN cord-009380-5uptbat3 149 18 proteins protein NNS cord-009380-5uptbat3 149 19 3 3 CD cord-009380-5uptbat3 149 20 . . . cord-009380-5uptbat3 150 1 Assays assay NNS cord-009380-5uptbat3 150 2 to to TO cord-009380-5uptbat3 150 3 monitor monitor VB cord-009380-5uptbat3 150 4 infections infection NNS cord-009380-5uptbat3 150 5 9 9 CD cord-009380-5uptbat3 151 1 In in IN cord-009380-5uptbat3 151 2 the the DT cord-009380-5uptbat3 151 3 environment environment NN cord-009380-5uptbat3 151 4 9 9 CD cord-009380-5uptbat3 151 5 In in IN cord-009380-5uptbat3 151 6 asymptomatic asymptomatic JJ cord-009380-5uptbat3 151 7 vectors vector NNS cord-009380-5uptbat3 151 8 ( ( -LRB- cord-009380-5uptbat3 151 9 potential potential JJ cord-009380-5uptbat3 151 10 transmissibility transmissibility NN cord-009380-5uptbat3 151 11 ) ) -RRB- cord-009380-5uptbat3 151 12 9 9 CD cord-009380-5uptbat3 152 1 In in IN cord-009380-5uptbat3 152 2 asymptomatic asymptomatic JJ cord-009380-5uptbat3 152 3 carriers carrier NNS cord-009380-5uptbat3 152 4 ( ( -LRB- cord-009380-5uptbat3 152 5 potential potential JJ cord-009380-5uptbat3 152 6 shedders shedder NNS cord-009380-5uptbat3 152 7 ) ) -RRB- cord-009380-5uptbat3 152 8 4 4 CD cord-009380-5uptbat3 152 9 . . . cord-009380-5uptbat3 153 1 Assays assay NNS cord-009380-5uptbat3 153 2 to to TO cord-009380-5uptbat3 153 3 diagnose diagnose VB cord-009380-5uptbat3 153 4 disease disease NN cord-009380-5uptbat3 153 5 9 9 CD cord-009380-5uptbat3 153 6 Prognosis prognosis NN cord-009380-5uptbat3 153 7 9 9 CD cord-009380-5uptbat3 153 8 Monitor Monitor NNP cord-009380-5uptbat3 153 9 response response NN cord-009380-5uptbat3 153 10 to to IN cord-009380-5uptbat3 153 11 treatment treatment NN cord-009380-5uptbat3 153 12 via via IN cord-009380-5uptbat3 153 13 cytokines cytokine NNS cord-009380-5uptbat3 153 14 ( ( -LRB- cord-009380-5uptbat3 153 15 IL-2 IL-2 NNP cord-009380-5uptbat3 153 16 , , , cord-009380-5uptbat3 153 17 IL-4 IL-4 NNP cord-009380-5uptbat3 153 18 , , , cord-009380-5uptbat3 153 19 etc etc FW cord-009380-5uptbat3 153 20 . . . cord-009380-5uptbat3 153 21 ) ) -RRB- cord-009380-5uptbat3 154 1 5 5 LS cord-009380-5uptbat3 154 2 . . . cord-009380-5uptbat3 155 1 Assays assay NNS cord-009380-5uptbat3 155 2 to to TO cord-009380-5uptbat3 155 3 track track VB cord-009380-5uptbat3 155 4 emerging emerge VBG cord-009380-5uptbat3 155 5 infections infection NNS cord-009380-5uptbat3 155 6 9 9 CD cord-009380-5uptbat3 155 7 Culture culture NN cord-009380-5uptbat3 155 8 invitro invitro NN cord-009380-5uptbat3 155 9 9 9 CD cord-009380-5uptbat3 155 10 Conserved conserve VBN cord-009380-5uptbat3 155 11 PCR PCR NNP cord-009380-5uptbat3 155 12 9 9 CD cord-009380-5uptbat3 155 13 Disease Disease NNP cord-009380-5uptbat3 155 14 potential potential JJ cord-009380-5uptbat3 155 15 9 9 CD cord-009380-5uptbat3 155 16 Develop develop VB cord-009380-5uptbat3 156 1 new new JJ cord-009380-5uptbat3 156 2 detection detection NN cord-009380-5uptbat3 156 3 assays assay NNS cord-009380-5uptbat3 156 4 9 9 CD cord-009380-5uptbat3 156 5 Develop develop VB cord-009380-5uptbat3 156 6 new new JJ cord-009380-5uptbat3 156 7 vaccines vaccine NNS