id sid tid token lemma pos cord-009101-376snefs 1 1 key key NN cord-009101-376snefs 1 2 : : : cord-009101-376snefs 2 1 cord-009101 cord-009101 NNP cord-009101-376snefs 2 2 - - HYPH cord-009101-376snefs 2 3 376snefs 376snefs JJ cord-009101-376snefs 2 4 authors author NNS cord-009101-376snefs 2 5 : : : cord-009101-376snefs 2 6 Strodtbeck Strodtbeck NNP cord-009101-376snefs 2 7 , , , cord-009101-376snefs 2 8 Frances Frances NNP cord-009101-376snefs 2 9 title title NN cord-009101-376snefs 2 10 : : : cord-009101-376snefs 2 11 Viral Viral NNP cord-009101-376snefs 2 12 Infections Infections NNPS cord-009101-376snefs 2 13 of of IN cord-009101-376snefs 2 14 the the DT cord-009101-376snefs 2 15 Newborn Newborn NNP cord-009101-376snefs 2 16 date date NN cord-009101-376snefs 2 17 : : : cord-009101-376snefs 2 18 2015 2015 CD cord-009101-376snefs 2 19 - - SYM cord-009101-376snefs 2 20 12 12 CD cord-009101-376snefs 2 21 - - SYM cord-009101-376snefs 2 22 16 16 CD cord-009101-376snefs 2 23 journal journal NN cord-009101-376snefs 2 24 : : : cord-009101-376snefs 2 25 J J NNP cord-009101-376snefs 2 26 Obstet Obstet NNP cord-009101-376snefs 2 27 Gynecol Gynecol NNP cord-009101-376snefs 2 28 Neonatal Neonatal NNP cord-009101-376snefs 2 29 Nurs Nurs NNP cord-009101-376snefs 2 30 DOI DOI NNP cord-009101-376snefs 2 31 : : : cord-009101-376snefs 2 32 10.1111 10.1111 CD cord-009101-376snefs 2 33 / / SYM cord-009101-376snefs 2 34 j.1552 j.1552 NN cord-009101-376snefs 2 35 - - HYPH cord-009101-376snefs 2 36 6909.1995.tb02548.x 6909.1995.tb02548.x NNP cord-009101-376snefs 2 37 sha sha NNP cord-009101-376snefs 2 38 : : : cord-009101-376snefs 3 1 05921d3a9348859386ce50b766cabc9e99c23d11 05921d3a9348859386ce50b766cabc9e99c23d11 NNP cord-009101-376snefs 3 2 doc_id doc_id CD cord-009101-376snefs 4 1 : : : cord-009101-376snefs 4 2 9101 9101 CD cord-009101-376snefs 4 3 cord_uid cord_uid NNS cord-009101-376snefs 4 4 : : : cord-009101-376snefs 5 1 376snefs 376snefs NNP cord-009101-376snefs 5 2 Viral viral JJ cord-009101-376snefs 5 3 infections infection NNS cord-009101-376snefs 5 4 of of IN cord-009101-376snefs 5 5 the the DT cord-009101-376snefs 5 6 newborn newborn JJ cord-009101-376snefs 5 7 result result NN cord-009101-376snefs 5 8 in in IN cord-009101-376snefs 5 9 significant significant JJ cord-009101-376snefs 5 10 morbidity morbidity NN cord-009101-376snefs 5 11 and and CC cord-009101-376snefs 5 12 mortality mortality NN cord-009101-376snefs 5 13 each each DT cord-009101-376snefs 5 14 year year NN cord-009101-376snefs 5 15 . . . cord-009101-376snefs 6 1 The the DT cord-009101-376snefs 6 2 fetus fetus NN cord-009101-376snefs 6 3 and and CC cord-009101-376snefs 6 4 newborn newborn JJ cord-009101-376snefs 6 5 are be VBP cord-009101-376snefs 6 6 particularly particularly RB cord-009101-376snefs 6 7 wlnerable wlnerable JJ cord-009101-376snefs 6 8 to to IN cord-009101-376snefs 6 9 viral viral JJ cord-009101-376snefs 6 10 infection infection NN cord-009101-376snefs 6 11 . . . cord-009101-376snefs 7 1 The the DT cord-009101-376snefs 7 2 range range NN cord-009101-376snefs 7 3 of of IN cord-009101-376snefs 7 4 expression expression NN cord-009101-376snefs 7 5 may may MD cord-009101-376snefs 7 6 vary vary VB cord-009101-376snefs 7 7 from from IN cord-009101-376snefs 7 8 no no DT cord-009101-376snefs 7 9 clinical clinical JJ cord-009101-376snefs 7 10 disease disease NN cord-009101-376snefs 7 11 to to IN cord-009101-376snefs 7 12 devastating devastating JJ cord-009101-376snefs 7 13 illness illness NN cord-009101-376snefs 7 14 and and CC cord-009101-376snefs 7 15 infection infection NN cord-009101-376snefs 7 16 occurring occur VBG cord-009101-376snefs 7 17 before before RB cord-009101-376snefs 7 18 , , , cord-009101-376snefs 7 19 during during IN cord-009101-376snefs 7 20 , , , cord-009101-376snefs 7 21 or or CC cord-009101-376snefs 7 22 after after IN cord-009101-376snefs 7 23 birth birth NN cord-009101-376snefs 7 24 . . . cord-009101-376snefs 8 1 Nursing nursing NN cord-009101-376snefs 8 2 management management NN cord-009101-376snefs 8 3 is be VBZ cord-009101-376snefs 8 4 determined determine VBN cord-009101-376snefs 8 5 by by IN cord-009101-376snefs 8 6 the the DT cord-009101-376snefs 8 7 specific specific JJ cord-009101-376snefs 8 8 viral viral JJ cord-009101-376snefs 8 9 infection infection NN cord-009101-376snefs 8 10 , , , cord-009101-376snefs 8 11 the the DT cord-009101-376snefs 8 12 severity severity NN cord-009101-376snefs 8 13 of of IN cord-009101-376snefs 8 14 the the DT cord-009101-376snefs 8 15 illness illness NN cord-009101-376snefs 8 16 , , , cord-009101-376snefs 8 17 and and CC cord-009101-376snefs 8 18 the the DT cord-009101-376snefs 8 19 unique unique JJ cord-009101-376snefs 8 20 conditions condition NNS cord-009101-376snefs 8 21 of of IN cord-009101-376snefs 8 22 the the DT cord-009101-376snefs 8 23 newborn newborn NN cord-009101-376snefs 8 24 and and CC cord-009101-376snefs 8 25 his -PRON- PRP$ cord-009101-376snefs 8 26 / / SYM cord-009101-376snefs 8 27 her -PRON- PRP$ cord-009101-376snefs 8 28 family family NN cord-009101-376snefs 8 29 . . . cord-009101-376snefs 9 1 Promising promise VBG cord-009101-376snefs 9 2 new new JJ cord-009101-376snefs 9 3 therapies therapy NNS cord-009101-376snefs 9 4 are be VBP cord-009101-376snefs 9 5 on on IN cord-009101-376snefs 9 6 the the DT cord-009101-376snefs 9 7 horizon horizon NN cord-009101-376snefs 9 8 that that WDT cord-009101-376snefs 9 9 may may MD cord-009101-376snefs 9 10 lessen lessen VB cord-009101-376snefs 9 11 the the DT cord-009101-376snefs 9 12 severity severity NN cord-009101-376snefs 9 13 of of IN cord-009101-376snefs 9 14 viral viral JJ cord-009101-376snefs 9 15 disease disease NN cord-009101-376snefs 9 16 . . . cord-009101-376snefs 10 1 Until until IN cord-009101-376snefs 10 2 such such JJ cord-009101-376snefs 10 3 time time NN cord-009101-376snefs 10 4 , , , cord-009101-376snefs 10 5 the the DT cord-009101-376snefs 10 6 major major JJ cord-009101-376snefs 10 7 thrusts thrust NNS cord-009101-376snefs 10 8 of of IN cord-009101-376snefs 10 9 management management NN cord-009101-376snefs 10 10 of of IN cord-009101-376snefs 10 11 neonatal neonatal JJ cord-009101-376snefs 10 12 viral viral JJ cord-009101-376snefs 10 13 disease disease NN cord-009101-376snefs 10 14 are be VBP cord-009101-376snefs 10 15 prevention prevention NN cord-009101-376snefs 10 16 of of IN cord-009101-376snefs 10 17 infection infection NN cord-009101-376snefs 10 18 and and CC cord-009101-376snefs 10 19 supportive supportive JJ cord-009101-376snefs 10 20 care care NN cord-009101-376snefs 10 21 for for IN cord-009101-376snefs 10 22 the the DT cord-009101-376snefs 10 23 acutely acutely RB cord-009101-376snefs 10 24 ill ill JJ cord-009101-376snefs 10 25 newborn newborn JJ cord-009101-376snefs 10 26 . . . cord-009101-376snefs 11 1 ical ical JJ cord-009101-376snefs 11 2 infection infection NN cord-009101-376snefs 11 3 can can MD cord-009101-376snefs 11 4 vary vary VB cord-009101-376snefs 11 5 from from IN cord-009101-376snefs 11 6 recovery recovery NN cord-009101-376snefs 11 7 to to IN cord-009101-376snefs 11 8 persistent persistent JJ cord-009101-376snefs 11 9 infection infection NN cord-009101-376snefs 11 10 with with IN cord-009101-376snefs 11 11 or or CC cord-009101-376snefs 11 12 without without IN cord-009101-376snefs 11 13 sequelae sequela NNS cord-009101-376snefs 11 14 to to IN cord-009101-376snefs 11 15 death death NN cord-009101-376snefs 11 16 ( ( -LRB- cord-009101-376snefs 11 17 Overall Overall NNP cord-009101-376snefs 11 18 , , , cord-009101-376snefs 11 19 1992 1992 CD cord-009101-376snefs 11 20 ; ; : cord-009101-376snefs 11 21 Smith Smith NNP cord-009101-376snefs 11 22 , , , cord-009101-376snefs 11 23 1993 1993 CD cord-009101-376snefs 11 24 ) ) -RRB- cord-009101-376snefs 11 25 . . . cord-009101-376snefs 12 1 This this DT cord-009101-376snefs 12 2 article article NN cord-009101-376snefs 12 3 reviews review VBZ cord-009101-376snefs 12 4 the the DT cord-009101-376snefs 12 5 unique unique JJ cord-009101-376snefs 12 6 pathogenesis pathogenesis NN cord-009101-376snefs 12 7 of of IN cord-009101-376snefs 12 8 newborn newborn JJ cord-009101-376snefs 12 9 viral viral JJ cord-009101-376snefs 12 10 infection infection NN cord-009101-376snefs 12 11 and and CC cord-009101-376snefs 12 12 the the DT cord-009101-376snefs 12 13 response response NN cord-009101-376snefs 12 14 of of IN cord-009101-376snefs 12 15 the the DT cord-009101-376snefs 12 16 neonatal neonatal JJ cord-009101-376snefs 12 17 immune immune JJ cord-009101-376snefs 12 18 system system NN cord-009101-376snefs 12 19 to to IN cord-009101-376snefs 12 20 viral viral JJ cord-009101-376snefs 12 21 attack attack NN cord-009101-376snefs 12 22 ; ; : cord-009101-376snefs 12 23 current current JJ cord-009101-376snefs 12 24 information information NN cord-009101-376snefs 12 25 on on IN cord-009101-376snefs 12 26 the the DT cord-009101-376snefs 12 27 clinical clinical JJ cord-009101-376snefs 12 28 features feature NNS cord-009101-376snefs 12 29 of of IN cord-009101-376snefs 12 30 specific specific JJ cord-009101-376snefs 12 31 viral viral JJ cord-009101-376snefs 12 32 diseases disease NNS cord-009101-376snefs 12 33 is be VBZ cord-009101-376snefs 12 34 summarized summarize VBN cord-009101-376snefs 12 35 . . . cord-009101-376snefs 13 1 The the DT cord-009101-376snefs 13 2 diagnosis diagnosis NN cord-009101-376snefs 13 3 , , , cord-009101-376snefs 13 4 management management NN cord-009101-376snefs 13 5 , , , cord-009101-376snefs 13 6 and and CC cord-009101-376snefs 13 7 nursing nursing NN cord-009101-376snefs 13 8 care care NN cord-009101-376snefs 13 9 of of IN cord-009101-376snefs 13 10 the the DT cord-009101-376snefs 13 11 newborn newborn NN cord-009101-376snefs 13 12 with with IN cord-009101-376snefs 13 13 a a DT cord-009101-376snefs 13 14 viral viral JJ cord-009101-376snefs 13 15 disease disease NN cord-009101-376snefs 13 16 are be VBP cord-009101-376snefs 13 17 addressed address VBN cord-009101-376snefs 13 18 . . . cord-009101-376snefs 14 1 The the DT cord-009101-376snefs 14 2 first first JJ cord-009101-376snefs 14 3 goal goal NN cord-009101-376snefs 14 4 and and CC cord-009101-376snefs 14 5 ultimate ultimate JJ cord-009101-376snefs 14 6 management management NN cord-009101-376snefs 14 7 of of IN cord-009101-376snefs 14 8 neonatal neonatal JJ cord-009101-376snefs 14 9 viral viral JJ cord-009101-376snefs 14 10 disease disease NN cord-009101-376snefs 14 11 is be VBZ cord-009101-376snefs 14 12 prevention prevention NN cord-009101-376snefs 14 13 of of IN cord-009101-376snefs 14 14 the the DT cord-009101-376snefs 14 15 infection infection NN cord-009101-376snefs 14 16 iral iral JJ cord-009101-376snefs 14 17 infections infection NNS cord-009101-376snefs 14 18 of of IN cord-009101-376snefs 14 19 the the DT cord-009101-376snefs 14 20 newborn newborn NN cord-009101-376snefs 14 21 are be VBP cord-009101-376snefs 14 22 a a DT cord-009101-376snefs 14 23 serious serious JJ cord-009101-376snefs 14 24 con con NN cord-009101-376snefs 14 25 - - HYPH cord-009101-376snefs 14 26 V v JJ cord-009101-376snefs 14 27 cern cern NNP cord-009101-376snefs 14 28 ; ; : cord-009101-376snefs 14 29 such such JJ cord-009101-376snefs 14 30 infections infection NNS cord-009101-376snefs 14 31 result result VBP cord-009101-376snefs 14 32 in in IN cord-009101-376snefs 14 33 significant significant JJ cord-009101-376snefs 14 34 morbidity morbidity NN cord-009101-376snefs 14 35 and and CC cord-009101-376snefs 14 36 mortality mortality NN cord-009101-376snefs 14 37 each each DT cord-009101-376snefs 14 38 year year NN cord-009101-376snefs 14 39 . . . cord-009101-376snefs 15 1 The the DT cord-009101-376snefs 15 2 incidence incidence NN cord-009101-376snefs 15 3 of of IN cord-009101-376snefs 15 4 viral viral JJ cord-009101-376snefs 15 5 infections infection NNS cord-009101-376snefs 15 6 in in IN cord-009101-376snefs 15 7 the the DT cord-009101-376snefs 15 8 newborn newborn NN cord-009101-376snefs 15 9 is be VBZ cord-009101-376snefs 15 10 estimated estimate VBN cord-009101-376snefs 15 11 at at IN cord-009101-376snefs 15 12 6 6 CD cord-009101-376snefs 15 13 - - SYM cord-009101-376snefs 15 14 8 8 CD cord-009101-376snefs 15 15 % % NN cord-009101-376snefs 15 16 of of IN cord-009101-376snefs 15 17 all all DT cord-009101-376snefs 15 18 live live JJ cord-009101-376snefs 15 19 births birth NNS cord-009101-376snefs 15 20 ( ( -LRB- cord-009101-376snefs 15 21 Smith Smith NNP cord-009101-376snefs 15 22 , , , cord-009101-376snefs 15 23 1993 1993 CD cord-009101-376snefs 15 24 ) ) -RRB- cord-009101-376snefs 15 25 . . . cord-009101-376snefs 16 1 The the DT cord-009101-376snefs 16 2 fetus fetus NN cord-009101-376snefs 16 3 and and CC cord-009101-376snefs 16 4 newborn newborn JJ cord-009101-376snefs 16 5 are be VBP cord-009101-376snefs 16 6 particularly particularly RB cord-009101-376snefs 16 7 vulnerable vulnerable JJ cord-009101-376snefs 16 8 to to IN cord-009101-376snefs 16 9 viral viral JJ cord-009101-376snefs 16 10 infection infection NN cord-009101-376snefs 16 11 for for IN cord-009101-376snefs 16 12 numerous numerous JJ cord-009101-376snefs 16 13 reasons reason NNS cord-009101-376snefs 16 14 , , , cord-009101-376snefs 16 15 including include VBG cord-009101-376snefs 16 16 a a DT cord-009101-376snefs 16 17 developing develop VBG cord-009101-376snefs 16 18 immune immune JJ cord-009101-376snefs 16 19 system system NN cord-009101-376snefs 16 20 that that WDT cord-009101-376snefs 16 21 is be VBZ cord-009101-376snefs 16 22 inadequate inadequate JJ cord-009101-376snefs 16 23 for for IN cord-009101-376snefs 16 24 preventing prevent VBG cord-009101-376snefs 16 25 infection infection NN cord-009101-376snefs 16 26 and and CC cord-009101-376snefs 16 27 containing contain VBG cord-009101-376snefs 16 28 the the DT cord-009101-376snefs 16 29 spread spread NN cord-009101-376snefs 16 30 of of IN cord-009101-376snefs 16 31 viruses virus NNS cord-009101-376snefs 16 32 , , , cord-009101-376snefs 16 33 lack lack NN cord-009101-376snefs 16 34 of of IN cord-009101-376snefs 16 35 immunologic immunologic JJ cord-009101-376snefs 16 36 experience experience NN cord-009101-376snefs 16 37 with with IN cord-009101-376snefs 16 38 viruses virus NNS cord-009101-376snefs 16 39 , , , cord-009101-376snefs 16 40 and and CC cord-009101-376snefs 16 41 the the DT cord-009101-376snefs 16 42 presence presence NN cord-009101-376snefs 16 43 of of IN cord-009101-376snefs 16 44 rapidly rapidly RB cord-009101-376snefs 16 45 growing grow VBG cord-009101-376snefs 16 46 cells cell NNS cord-009101-376snefs 16 47 and and CC cord-009101-376snefs 16 48 tissues tissue NNS cord-009101-376snefs 16 49 ( ( -LRB- cord-009101-376snefs 16 50 Strodtbeck Strodtbeck NNP cord-009101-376snefs 16 51 , , , cord-009101-376snefs 16 52 1986 1986 CD cord-009101-376snefs 16 53 ) ) -RRB- cord-009101-376snefs 16 54 . . . cord-009101-376snefs 17 1 Viral viral JJ cord-009101-376snefs 17 2 infection infection NN cord-009101-376snefs 17 3 in in IN cord-009101-376snefs 17 4 the the DT cord-009101-376snefs 17 5 newborn newborn NN cord-009101-376snefs 17 6 can can MD cord-009101-376snefs 17 7 vary vary VB cord-009101-376snefs 17 8 from from IN cord-009101-376snefs 17 9 no no DT cord-009101-376snefs 17 10 clinical clinical JJ cord-009101-376snefs 17 11 disease disease NN cord-009101-376snefs 17 12 to to IN cord-009101-376snefs 17 13 devastating devastating JJ cord-009101-376snefs 17 14 illness illness NN cord-009101-376snefs 17 15 . . . cord-009101-376snefs 18 1 Infection infection NN cord-009101-376snefs 18 2 of of IN cord-009101-376snefs 18 3 the the DT cord-009101-376snefs 18 4 newborn newborn NN cord-009101-376snefs 18 5 with with IN cord-009101-376snefs 18 6 a a DT cord-009101-376snefs 18 7 virus virus NN cord-009101-376snefs 18 8 produces produce VBZ cord-009101-376snefs 18 9 a a DT cord-009101-376snefs 18 10 variety variety NN cord-009101-376snefs 18 11 of of IN cord-009101-376snefs 18 12 clinical clinical JJ cord-009101-376snefs 18 13 presentations presentation NNS cord-009101-376snefs 18 14 , , , cord-009101-376snefs 18 15 ranging range VBG cord-009101-376snefs 18 16 from from IN cord-009101-376snefs 18 17 absence absence NN cord-009101-376snefs 18 18 of of IN cord-009101-376snefs 18 19 symptoms symptom NNS cord-009101-376snefs 18 20 to to IN cord-009101-376snefs 18 21 infection infection NN cord-009101-376snefs 18 22 before before IN cord-009101-376snefs 18 23 ( ( -LRB- cord-009101-376snefs 18 24 congenital congenital JJ cord-009101-376snefs 18 25 ) ) -RRB- cord-009101-376snefs 18 26 , , , cord-009101-376snefs 18 27 during during IN cord-009101-376snefs 18 28 ( ( -LRB- cord-009101-376snefs 18 29 natal natal NNP cord-009101-376snefs 18 30 ) ) -RRB- cord-009101-376snefs 18 31 , , , cord-009101-376snefs 18 32 or or CC cord-009101-376snefs 18 33 after after IN cord-009101-376snefs 18 34 birth birth NN cord-009101-376snefs 18 35 ( ( -LRB- cord-009101-376snefs 18 36 postnatal postnatal NN cord-009101-376snefs 18 37 ) ) -RRB- cord-009101-376snefs 18 38 ( ( -LRB- cord-009101-376snefs 18 39 Overall Overall NNP cord-009101-376snefs 18 40 , , , cord-009101-376snefs 18 41 1992 1992 CD cord-009101-376snefs 18 42 ) ) -RRB- cord-009101-376snefs 18 43 . . . cord-009101-376snefs 19 1 Because because IN cord-009101-376snefs 19 2 of of IN cord-009101-376snefs 19 3 the the DT cord-009101-376snefs 19 4 affinity affinity NN cord-009101-376snefs 19 5 of of IN cord-009101-376snefs 19 6 viruses virus NNS cord-009101-376snefs 19 7 for for IN cord-009101-376snefs 19 8 rapidly rapidly RB cord-009101-376snefs 19 9 growing grow VBG cord-009101-376snefs 19 10 cells cell NNS cord-009101-376snefs 19 11 , , , cord-009101-376snefs 19 12 newborn newborn JJ cord-009101-376snefs 19 13 infection infection NN cord-009101-376snefs 19 14 results result NNS cord-009101-376snefs 19 15 in in IN cord-009101-376snefs 19 16 multiple multiple JJ cord-009101-376snefs 19 17 outcomes outcome NNS cord-009101-376snefs 19 18 that that WDT cord-009101-376snefs 19 19 are be VBP cord-009101-376snefs 19 20 determined determine VBN cord-009101-376snefs 19 21 by by IN cord-009101-376snefs 19 22 the the DT cord-009101-376snefs 19 23 specific specific JJ cord-009101-376snefs 19 24 virus virus NN cord-009101-376snefs 19 25 and and CC cord-009101-376snefs 19 26 the the DT cord-009101-376snefs 19 27 gestational gestational JJ cord-009101-376snefs 19 28 age age NN cord-009101-376snefs 19 29 at at IN cord-009101-376snefs 19 30 the the DT cord-009101-376snefs 19 31 onset onset NN cord-009101-376snefs 19 32 of of IN cord-009101-376snefs 19 33 infection infection NN cord-009101-376snefs 19 34 . . . cord-009101-376snefs 20 1 Congenital congenital JJ cord-009101-376snefs 20 2 viral viral JJ cord-009101-376snefs 20 3 infections infection NNS cord-009101-376snefs 20 4 may may MD cord-009101-376snefs 20 5 result result VB cord-009101-376snefs 20 6 in in IN cord-009101-376snefs 20 7 miscarriage miscarriage NN cord-009101-376snefs 20 8 or or CC cord-009101-376snefs 20 9 stillbirth stillbirth NN cord-009101-376snefs 20 10 , , , cord-009101-376snefs 20 11 congenital congenital JJ cord-009101-376snefs 20 12 defects defect NNS cord-009101-376snefs 20 13 of of IN cord-009101-376snefs 20 14 various various JJ cord-009101-376snefs 20 15 organ organ NN cord-009101-376snefs 20 16 systems system NNS cord-009101-376snefs 20 17 , , , cord-009101-376snefs 20 18 clinical clinical JJ cord-009101-376snefs 20 19 infection infection NN cord-009101-376snefs 20 20 , , , cord-009101-376snefs 20 21 or or CC cord-009101-376snefs 20 22 asymptomatic asymptomatic JJ cord-009101-376snefs 20 23 infection infection NN cord-009101-376snefs 20 24 . . . cord-009101-376snefs 21 1 Natal natal JJ cord-009101-376snefs 21 2 and and CC cord-009101-376snefs 21 3 postnatal postnatal JJ cord-009101-376snefs 21 4 infections infection NNS cord-009101-376snefs 21 5 can can MD cord-009101-376snefs 21 6 result result VB cord-009101-376snefs 21 7 in in IN cord-009101-376snefs 21 8 asymptomatic asymptomatic JJ cord-009101-376snefs 21 9 infection infection NN cord-009101-376snefs 21 10 or or CC cord-009101-376snefs 21 11 clinical clinical JJ cord-009101-376snefs 21 12 infection infection NN cord-009101-376snefs 21 13 . . . cord-009101-376snefs 22 1 Outcomes outcome NNS cord-009101-376snefs 22 2 of of IN cord-009101-376snefs 22 3 clin- clin- NN cord-009101-376snefs 22 4 Viruses virus NNS cord-009101-376snefs 22 5 are be VBP cord-009101-376snefs 22 6 unique unique JJ cord-009101-376snefs 22 7 microorganisms microorganism NNS cord-009101-376snefs 22 8 in in IN cord-009101-376snefs 22 9 that that IN cord-009101-376snefs 22 10 they -PRON- PRP cord-009101-376snefs 22 11 are be VBP cord-009101-376snefs 22 12 obligatory obligatory JJ cord-009101-376snefs 22 13 intracellular intracellular JJ cord-009101-376snefs 22 14 parasites parasite NNS cord-009101-376snefs 22 15 that that WDT cord-009101-376snefs 22 16 must must MD cord-009101-376snefs 22 17 gain gain VB cord-009101-376snefs 22 18 access access NN cord-009101-376snefs 22 19 to to IN cord-009101-376snefs 22 20 the the DT cord-009101-376snefs 22 21 inside inside NN cord-009101-376snefs 22 22 of of IN cord-009101-376snefs 22 23 a a DT cord-009101-376snefs 22 24 host host NN cord-009101-376snefs 22 25 cell cell NN cord-009101-376snefs 22 26 for for IN cord-009101-376snefs 22 27 replication replication NN cord-009101-376snefs 22 28 . . . cord-009101-376snefs 23 1 Physical physical JJ cord-009101-376snefs 23 2 contact contact NN cord-009101-376snefs 23 3 is be VBZ cord-009101-376snefs 23 4 necessary necessary JJ cord-009101-376snefs 23 5 for for IN cord-009101-376snefs 23 6 this this DT cord-009101-376snefs 23 7 process process NN cord-009101-376snefs 23 8 , , , cord-009101-376snefs 23 9 and and CC cord-009101-376snefs 23 10 many many JJ cord-009101-376snefs 23 11 factors factor NNS cord-009101-376snefs 23 12 influence influence VBP cord-009101-376snefs 23 13 the the DT cord-009101-376snefs 23 14 attraction attraction NN cord-009101-376snefs 23 15 between between IN cord-009101-376snefs 23 16 the the DT cord-009101-376snefs 23 17 host host NN cord-009101-376snefs 23 18 cell cell NN cord-009101-376snefs 23 19 and and CC cord-009101-376snefs 23 20 the the DT cord-009101-376snefs 23 21 invading invade VBG cord-009101-376snefs 23 22 virus virus NN cord-009101-376snefs 23 23 . . . cord-009101-376snefs 24 1 The the DT cord-009101-376snefs 24 2 structure structure NN cord-009101-376snefs 24 3 of of IN cord-009101-376snefs 24 4 an an DT cord-009101-376snefs 24 5 individual individual JJ cord-009101-376snefs 24 6 virus virus NN cord-009101-376snefs 24 7 and and CC cord-009101-376snefs 24 8 the the DT cord-009101-376snefs 24 9 presence presence NN cord-009101-376snefs 24 10 of of IN cord-009101-376snefs 24 11 certain certain JJ cord-009101-376snefs 24 12 enzymes enzyme NNS cord-009101-376snefs 24 13 determine determine VBP cord-009101-376snefs 24 14 the the DT cord-009101-376snefs 24 15 mechanism mechanism NN cord-009101-376snefs 24 16 by by IN cord-009101-376snefs 24 17 which which WDT cord-009101-376snefs 24 18 the the DT cord-009101-376snefs 24 19 virus virus NN cord-009101-376snefs 24 20 replicates replicate VBZ cord-009101-376snefs 24 21 inside inside IN cord-009101-376snefs 24 22 the the DT cord-009101-376snefs 24 23 host host NN cord-009101-376snefs 24 24 cell cell NN cord-009101-376snefs 24 25 . . . cord-009101-376snefs 25 1 Viral viral JJ cord-009101-376snefs 25 2 replication replication NN cord-009101-376snefs 25 3 follows follow VBZ cord-009101-376snefs 25 4 five five CD cord-009101-376snefs 25 5 basic basic JJ cord-009101-376snefs 25 6 steps step NNS cord-009101-376snefs 25 7 . . . cord-009101-376snefs 26 1 proteins protein NNS cord-009101-376snefs 26 2 using use VBG cord-009101-376snefs 26 3 host host NN cord-009101-376snefs 26 4 cell cell NN cord-009101-376snefs 26 5 components component NNS cord-009101-376snefs 26 6 and and CC cord-009101-376snefs 26 7 metabolism metabolism NN cord-009101-376snefs 26 8 ; ; : cord-009101-376snefs 26 9 4 4 CD cord-009101-376snefs 26 10 . . . cord-009101-376snefs 26 11 assembly assembly NN cord-009101-376snefs 26 12 of of IN cord-009101-376snefs 26 13 new new JJ cord-009101-376snefs 26 14 virions virion NNS cord-009101-376snefs 26 15 in in IN cord-009101-376snefs 26 16 the the DT cord-009101-376snefs 26 17 cytoplasm cytoplasm NN cord-009101-376snefs 26 18 ; ; : cord-009101-376snefs 26 19 and and CC cord-009101-376snefs 26 20 5 5 CD cord-009101-376snefs 26 21 . . . cord-009101-376snefs 27 1 release release NN cord-009101-376snefs 27 2 of of IN cord-009101-376snefs 27 3 the the DT cord-009101-376snefs 27 4 new new JJ cord-009101-376snefs 27 5 virions virion NNS cord-009101-376snefs 27 6 into into IN cord-009101-376snefs 27 7 the the DT cord-009101-376snefs 27 8 intracellular intracellular JJ cord-009101-376snefs 27 9 environment environment NN cord-009101-376snefs 27 10 . . . cord-009101-376snefs 28 1 Release release NN cord-009101-376snefs 28 2 of of IN cord-009101-376snefs 28 3 the the DT cord-009101-376snefs 28 4 virus virus NN cord-009101-376snefs 28 5 can can MD cord-009101-376snefs 28 6 occur occur VB cord-009101-376snefs 28 7 quickly quickly RB cord-009101-376snefs 28 8 or or CC cord-009101-376snefs 28 9 slowly slowly RB cord-009101-376snefs 28 10 and and CC cord-009101-376snefs 28 11 frequently frequently RB cord-009101-376snefs 28 12 results result VBZ cord-009101-376snefs 28 13 in in IN cord-009101-376snefs 28 14 destruction destruction NN cord-009101-376snefs 28 15 of of IN cord-009101-376snefs 28 16 the the DT cord-009101-376snefs 28 17 host host NN cord-009101-376snefs 28 18 cell cell NN cord-009101-376snefs 28 19 ( ( -LRB- cord-009101-376snefs 28 20 Strodtbeck Strodtbeck NNP cord-009101-376snefs 28 21 , , , cord-009101-376snefs 28 22 1986 1986 CD cord-009101-376snefs 28 23 ; ; : cord-009101-376snefs 28 24 Voyles Voyles NNP cord-009101-376snefs 28 25 , , , cord-009101-376snefs 28 26 1993 1993 CD cord-009101-376snefs 28 27 ) ) -RRB- cord-009101-376snefs 28 28 . . . cord-009101-376snefs 29 1 or or CC cord-009101-376snefs 29 2 lysis lysis NN cord-009101-376snefs 29 3 . . . cord-009101-376snefs 30 1 Latency Latency NNP cord-009101-376snefs 30 2 occurs occur VBZ cord-009101-376snefs 30 3 when when WRB cord-009101-376snefs 30 4 the the DT cord-009101-376snefs 30 5 provirus provirus NNP cord-009101-376snefs 30 6 reproduces reproduce VBZ cord-009101-376snefs 30 7 itself -PRON- PRP cord-009101-376snefs 30 8 along along IN cord-009101-376snefs 30 9 with with IN cord-009101-376snefs 30 10 the the DT cord-009101-376snefs 30 11 host host NN cord-009101-376snefs 30 12 cell cell NN cord-009101-376snefs 30 13 such such JJ cord-009101-376snefs 30 14 that that IN cord-009101-376snefs 30 15 all all DT cord-009101-376snefs 30 16 daughter daughter NN cord-009101-376snefs 30 17 cells cell NNS cord-009101-376snefs 30 18 contain contain VBP cord-009101-376snefs 30 19 the the DT cord-009101-376snefs 30 20 viral viral JJ cord-009101-376snefs 30 21 genetic genetic JJ cord-009101-376snefs 30 22 material material NN cord-009101-376snefs 30 23 . . . cord-009101-376snefs 31 1 These these DT cord-009101-376snefs 31 2 cells cell NNS cord-009101-376snefs 31 3 can can MD cord-009101-376snefs 31 4 remain remain VB cord-009101-376snefs 31 5 latent latent JJ cord-009101-376snefs 31 6 or or CC cord-009101-376snefs 31 7 be be VB cord-009101-376snefs 31 8 triggered trigger VBN cord-009101-376snefs 31 9 into into IN cord-009101-376snefs 31 10 one one CD cord-009101-376snefs 31 11 of of IN cord-009101-376snefs 31 12 the the DT cord-009101-376snefs 31 13 other other JJ cord-009101-376snefs 31 14 two two CD cord-009101-376snefs 31 15 outcomes outcome NNS cord-009101-376snefs 31 16 at at IN cord-009101-376snefs 31 17 a a DT cord-009101-376snefs 31 18 future future JJ cord-009101-376snefs 31 19 time time NN cord-009101-376snefs 31 20 . . . cord-009101-376snefs 32 1 A a DT cord-009101-376snefs 32 2 classic classic JJ cord-009101-376snefs 32 3 example example NN cord-009101-376snefs 32 4 of of IN cord-009101-376snefs 32 5 latency latency NNP cord-009101-376snefs 32 6 is be VBZ cord-009101-376snefs 32 7 the the DT cord-009101-376snefs 32 8 herpes herpes NNP cord-009101-376snefs 32 9 virus virus NN cord-009101-376snefs 32 10 , , , cord-009101-376snefs 32 11 which which WDT cord-009101-376snefs 32 12 can can MD cord-009101-376snefs 32 13 remain remain VB cord-009101-376snefs 32 14 dormant dormant JJ cord-009101-376snefs 32 15 until until IN cord-009101-376snefs 32 16 a a DT cord-009101-376snefs 32 17 trigger trigger NN cord-009101-376snefs 32 18 such such JJ cord-009101-376snefs 32 19 as as IN cord-009101-376snefs 32 20 stress stress NN cord-009101-376snefs 32 21 activates activate VBZ cord-009101-376snefs 32 22 the the DT cord-009101-376snefs 32 23 virus virus NN cord-009101-376snefs 32 24 and and CC cord-009101-376snefs 32 25 a a DT cord-009101-376snefs 32 26 characteristic characteristic JJ cord-009101-376snefs 32 27 herpetic herpetic JJ cord-009101-376snefs 32 28 skin skin NN cord-009101-376snefs 32 29 lesion lesion NN cord-009101-376snefs 32 30 is be VBZ cord-009101-376snefs 32 31 produced produce VBN cord-009101-376snefs 32 32 . . . cord-009101-376snefs 33 1 In in IN cord-009101-376snefs 33 2 the the DT cord-009101-376snefs 33 3 controlled control VBN cord-009101-376snefs 33 4 growth growth NN cord-009101-376snefs 33 5 outcome outcome NN cord-009101-376snefs 33 6 , , , cord-009101-376snefs 33 7 the the DT cord-009101-376snefs 33 8 host host NN cord-009101-376snefs 33 9 cell cell NN cord-009101-376snefs 33 10 is be VBZ cord-009101-376snefs 33 11 not not RB cord-009101-376snefs 33 12 destroyed destroy VBN cord-009101-376snefs 33 13 but but CC cord-009101-376snefs 33 14 becomes become VBZ cord-009101-376snefs 33 15 committed commit VBN cord-009101-376snefs 33 16 to to IN cord-009101-376snefs 33 17 the the DT cord-009101-376snefs 33 18 production production NN cord-009101-376snefs 33 19 of of IN cord-009101-376snefs 33 20 new new JJ cord-009101-376snefs 33 21 virions virion NNS cord-009101-376snefs 33 22 , , , cord-009101-376snefs 33 23 which which WDT cord-009101-376snefs 33 24 are be VBP cord-009101-376snefs 33 25 gradually gradually RB cord-009101-376snefs 33 26 released release VBN cord-009101-376snefs 33 27 into into IN cord-009101-376snefs 33 28 the the DT cord-009101-376snefs 33 29 surrounding surround VBG cord-009101-376snefs 33 30 interstitial interstitial JJ cord-009101-376snefs 33 31 space space NN cord-009101-376snefs 33 32 . . . cord-009101-376snefs 34 1 The the DT cord-009101-376snefs 34 2 last last JJ cord-009101-376snefs 34 3 outcome outcome NN cord-009101-376snefs 34 4 , , , cord-009101-376snefs 34 5 lysis lysis NN cord-009101-376snefs 34 6 , , , cord-009101-376snefs 34 7 involves involve VBZ cord-009101-376snefs 34 8 destruction destruction NN cord-009101-376snefs 34 9 of of IN cord-009101-376snefs 34 10 the the DT cord-009101-376snefs 34 11 host host NN cord-009101-376snefs 34 12 cell cell NN cord-009101-376snefs 34 13 upon upon IN cord-009101-376snefs 34 14 release release NN cord-009101-376snefs 34 15 of of IN cord-009101-376snefs 34 16 the the DT cord-009101-376snefs 34 17 newly newly RB cord-009101-376snefs 34 18 formed form VBN cord-009101-376snefs 34 19 virions virion NNS cord-009101-376snefs 34 20 . . . cord-009101-376snefs 35 1 This this DT cord-009101-376snefs 35 2 process process NN cord-009101-376snefs 35 3 is be VBZ cord-009101-376snefs 35 4 referred refer VBN cord-009101-376snefs 35 5 to to IN cord-009101-376snefs 35 6 as as IN cord-009101-376snefs 35 7 the the DT cord-009101-376snefs 35 8 cytopathic cytopathic JJ cord-009101-376snefs 35 9 effect effect NN cord-009101-376snefs 35 10 and and CC cord-009101-376snefs 35 11 often often RB cord-009101-376snefs 35 12 results result VBZ cord-009101-376snefs 35 13 in in IN cord-009101-376snefs 35 14 patterned pattern VBN cord-009101-376snefs 35 15 tissue tissue NN cord-009101-376snefs 35 16 damage damage NN cord-009101-376snefs 35 17 that that WDT cord-009101-376snefs 35 18 can can MD cord-009101-376snefs 35 19 be be VB cord-009101-376snefs 35 20 used use VBN cord-009101-376snefs 35 21 in in IN cord-009101-376snefs 35 22 the the DT cord-009101-376snefs 35 23 clinical clinical JJ cord-009101-376snefs 35 24 laboratory laboratory NN cord-009101-376snefs 35 25 for for IN cord-009101-376snefs 35 26 identification identification NN cord-009101-376snefs 35 27 of of IN cord-009101-376snefs 35 28 the the DT cord-009101-376snefs 35 29 virus virus NN cord-009101-376snefs 35 30 ( ( -LRB- cord-009101-376snefs 35 31 Strodtbeck Strodtbeck NNP cord-009101-376snefs 35 32 , , , cord-009101-376snefs 35 33 1986 1986 CD cord-009101-376snefs 35 34 ; ; : cord-009101-376snefs 35 35 Voyles Voyles NNP cord-009101-376snefs 35 36 , , , cord-009101-376snefs 35 37 1993 1993 CD cord-009101-376snefs 35 38 ) ) -RRB- cord-009101-376snefs 35 39 . . . cord-009101-376snefs 36 1 From from IN cord-009101-376snefs 36 2 this this DT cord-009101-376snefs 36 3 discussion discussion NN cord-009101-376snefs 36 4 , , , cord-009101-376snefs 36 5 it -PRON- PRP cord-009101-376snefs 36 6 should should MD cord-009101-376snefs 36 7 be be VB cord-009101-376snefs 36 8 clear clear JJ cord-009101-376snefs 36 9 why why WRB cord-009101-376snefs 36 10 viral viral JJ cord-009101-376snefs 36 11 infections infection NNS cord-009101-376snefs 36 12 can can MD cord-009101-376snefs 36 13 result result VB cord-009101-376snefs 36 14 a a DT cord-009101-376snefs 36 15 such such JJ cord-009101-376snefs 36 16 a a DT cord-009101-376snefs 36 17 wide wide JJ cord-009101-376snefs 36 18 array array NN cord-009101-376snefs 36 19 of of IN cord-009101-376snefs 36 20 presentations presentation NNS cord-009101-376snefs 36 21 . . . cord-009101-376snefs 37 1 Because because IN cord-009101-376snefs 37 2 of of IN cord-009101-376snefs 37 3 the the DT cord-009101-376snefs 37 4 intracellular intracellular JJ cord-009101-376snefs 37 5 , , , cord-009101-376snefs 37 6 parasitic parasitic JJ cord-009101-376snefs 37 7 nature nature NN cord-009101-376snefs 37 8 of of IN cord-009101-376snefs 37 9 viruses virus NNS cord-009101-376snefs 37 10 and and CC cord-009101-376snefs 37 11 the the DT cord-009101-376snefs 37 12 resulting result VBG cord-009101-376snefs 37 13 dependence dependence NN cord-009101-376snefs 37 14 on on IN cord-009101-376snefs 37 15 host host NN cord-009101-376snefs 37 16 cell cell NN cord-009101-376snefs 37 17 metabolic metabolic JJ cord-009101-376snefs 37 18 machinery machinery NN cord-009101-376snefs 37 19 for for IN cord-009101-376snefs 37 20 proliferation proliferation NN cord-009101-376snefs 37 21 , , , cord-009101-376snefs 37 22 the the DT cord-009101-376snefs 37 23 use use NN cord-009101-376snefs 37 24 of of IN cord-009101-376snefs 37 25 antiviral antiviral JJ cord-009101-376snefs 37 26 drug drug NN cord-009101-376snefs 37 27 therapy therapy NN cord-009101-376snefs 37 28 is be VBZ cord-009101-376snefs 37 29 limited limit VBN cord-009101-376snefs 37 30 . . . cord-009101-376snefs 38 1 Many many JJ cord-009101-376snefs 38 2 of of IN cord-009101-376snefs 38 3 the the DT cord-009101-376snefs 38 4 drugs drug NNS cord-009101-376snefs 38 5 developed develop VBN cord-009101-376snefs 38 6 for for IN cord-009101-376snefs 38 7 viral viral JJ cord-009101-376snefs 38 8 disease disease NN cord-009101-376snefs 38 9 also also RB cord-009101-376snefs 38 10 have have VBP cord-009101-376snefs 38 11 an an DT cord-009101-376snefs 38 12 effect effect NN cord-009101-376snefs 38 13 on on IN cord-009101-376snefs 38 14 rapidly rapidly RB cord-009101-376snefs 38 15 growing grow VBG cord-009101-376snefs 38 16 cells cell NNS cord-009101-376snefs 38 17 , , , cord-009101-376snefs 38 18 which which WDT cord-009101-376snefs 38 19 limits limit VBZ cord-009101-376snefs 38 20 their -PRON- PRP$ cord-009101-376snefs 38 21 use use NN cord-009101-376snefs 38 22 in in IN cord-009101-376snefs 38 23 the the DT cord-009101-376snefs 38 24 newborn newborn NN cord-009101-376snefs 38 25 . . . cord-009101-376snefs 39 1 Thus thus RB cord-009101-376snefs 39 2 , , , cord-009101-376snefs 39 3 the the DT cord-009101-376snefs 39 4 newborn newborn NN cord-009101-376snefs 39 5 is be VBZ cord-009101-376snefs 39 6 not not RB cord-009101-376snefs 39 7 only only RB cord-009101-376snefs 39 8 vulnerable vulnerable JJ cord-009101-376snefs 39 9 to to IN cord-009101-376snefs 39 10 infection infection NN cord-009101-376snefs 39 11 , , , cord-009101-376snefs 39 12 but but CC cord-009101-376snefs 39 13 also also RB cord-009101-376snefs 39 14 is be VBZ cord-009101-376snefs 39 15 disadvantaged disadvantaged JJ cord-009101-376snefs 39 16 for for IN cord-009101-376snefs 39 17 viable viable JJ cord-009101-376snefs 39 18 treatment treatment NN cord-009101-376snefs 39 19 options option NNS cord-009101-376snefs 39 20 . . . cord-009101-376snefs 40 1 The the DT cord-009101-376snefs 40 2 newborn newborn JJ cord-009101-376snefs 40 3 infected infect VBN cord-009101-376snefs 40 4 with with IN cord-009101-376snefs 40 5 a a DT cord-009101-376snefs 40 6 virus virus NN cord-009101-376snefs 40 7 is be VBZ cord-009101-376snefs 40 8 capable capable JJ cord-009101-376snefs 40 9 of of IN cord-009101-376snefs 40 10 mounting mount VBG cord-009101-376snefs 40 11 an an DT cord-009101-376snefs 40 12 immune immune JJ cord-009101-376snefs 40 13 system system NN cord-009101-376snefs 40 14 response response NN cord-009101-376snefs 40 15 . . . cord-009101-376snefs 41 1 The the DT cord-009101-376snefs 41 2 response response NN cord-009101-376snefs 41 3 depends depend VBZ cord-009101-376snefs 41 4 upon upon IN cord-009101-376snefs 41 5 the the DT cord-009101-376snefs 41 6 gestational gestational JJ cord-009101-376snefs 41 7 age age NN cord-009101-376snefs 41 8 of of IN cord-009101-376snefs 41 9 the the DT cord-009101-376snefs 41 10 newborn newborn NN cord-009101-376snefs 41 11 and and CC cord-009101-376snefs 41 12 is be VBZ cord-009101-376snefs 41 13 not not RB cord-009101-376snefs 41 14 as as RB cord-009101-376snefs 41 15 efficient efficient JJ cord-009101-376snefs 41 16 or or CC cord-009101-376snefs 41 17 effective effective JJ cord-009101-376snefs 41 18 as as IN cord-009101-376snefs 41 19 the the DT cord-009101-376snefs 41 20 response response NN cord-009101-376snefs 41 21 of of IN cord-009101-376snefs 41 22 an an DT cord-009101-376snefs 41 23 adult adult NN cord-009101-376snefs 41 24 . . . cord-009101-376snefs 42 1 Clinical clinical JJ cord-009101-376snefs 42 2 viral viral JJ cord-009101-376snefs 42 3 infection infection NN cord-009101-376snefs 42 4 in in IN cord-009101-376snefs 42 5 newborns newborn NNS cord-009101-376snefs 42 6 usually usually RB cord-009101-376snefs 42 7 results result VBZ cord-009101-376snefs 42 8 in in IN cord-009101-376snefs 42 9 a a DT cord-009101-376snefs 42 10 more more RBR cord-009101-376snefs 42 11 rapid rapid JJ cord-009101-376snefs 42 12 progression progression NN cord-009101-376snefs 42 13 to to IN cord-009101-376snefs 42 14 full full RB cord-009101-376snefs 42 15 - - HYPH cord-009101-376snefs 42 16 blown blow VBN cord-009101-376snefs 42 17 disease disease NN cord-009101-376snefs 42 18 and and CC cord-009101-376snefs 42 19 earlier early JJR cord-009101-376snefs 42 20 onset onset NN cord-009101-376snefs 42 21 of of IN cord-009101-376snefs 42 22 symptomatic symptomatic JJ cord-009101-376snefs 42 23 organ organ NN cord-009101-376snefs 42 24 involvement involvement NN cord-009101-376snefs 42 25 than than IN cord-009101-376snefs 42 26 would would MD cord-009101-376snefs 42 27 be be VB cord-009101-376snefs 42 28 seen see VBN cord-009101-376snefs 42 29 in in IN cord-009101-376snefs 42 30 adults adult NNS cord-009101-376snefs 42 31 with with IN cord-009101-376snefs 42 32 the the DT cord-009101-376snefs 42 33 same same JJ cord-009101-376snefs 42 34 infection infection NN cord-009101-376snefs 42 35 ( ( -LRB- cord-009101-376snefs 42 36 Overall Overall NNP cord-009101-376snefs 42 37 , , , cord-009101-376snefs 42 38 1992 1992 CD cord-009101-376snefs 42 39 ; ; : cord-009101-376snefs 42 40 Smith Smith NNP cord-009101-376snefs 42 41 , , , cord-009101-376snefs 42 42 1993 1993 CD cord-009101-376snefs 42 43 ; ; : cord-009101-376snefs 42 44 Strodtbeck Strodtbeck NNP cord-009101-376snefs 42 45 , , , cord-009101-376snefs 42 46 1986 1986 CD cord-009101-376snefs 42 47 ) ) -RRB- cord-009101-376snefs 42 48 . . . cord-009101-376snefs 43 1 Entry entry NN cord-009101-376snefs 43 2 of of IN cord-009101-376snefs 43 3 the the DT cord-009101-376snefs 43 4 virus virus NN cord-009101-376snefs 43 5 into into IN cord-009101-376snefs 43 6 the the DT cord-009101-376snefs 43 7 newborn newborn JJ cord-009101-376snefs 43 8 triggers trigger NNS cord-009101-376snefs 43 9 activation activation NN cord-009101-376snefs 43 10 of of IN cord-009101-376snefs 43 11 the the DT cord-009101-376snefs 43 12 developing develop VBG cord-009101-376snefs 43 13 immune immune JJ cord-009101-376snefs 43 14 system system NN cord-009101-376snefs 43 15 . . . cord-009101-376snefs 44 1 Local local JJ cord-009101-376snefs 44 2 antibodies antibody NNS cord-009101-376snefs 44 3 such such JJ cord-009101-376snefs 44 4 as as IN cord-009101-376snefs 44 5 IgA IgA NNP cord-009101-376snefs 44 6 are be VBP cord-009101-376snefs 44 7 stimulated stimulate VBN cord-009101-376snefs 44 8 . . . cord-009101-376snefs 45 1 Because because IN cord-009101-376snefs 45 2 of of IN cord-009101-376snefs 45 3 their -PRON- PRP$ cord-009101-376snefs 45 4 inability inability NN cord-009101-376snefs 45 5 to to TO cord-009101-376snefs 45 6 contain contain VB cord-009101-376snefs 45 7 the the DT cord-009101-376snefs 45 8 virus virus NN cord-009101-376snefs 45 9 , , , cord-009101-376snefs 45 10 a a DT cord-009101-376snefs 45 11 primary primary JJ cord-009101-376snefs 45 12 focus focus NN cord-009101-376snefs 45 13 of of IN cord-009101-376snefs 45 14 infection infection NN cord-009101-376snefs 45 15 is be VBZ cord-009101-376snefs 45 16 established establish VBN cord-009101-376snefs 45 17 . . . cord-009101-376snefs 46 1 The the DT cord-009101-376snefs 46 2 virus virus NN cord-009101-376snefs 46 3 replicates replicate VBZ cord-009101-376snefs 46 4 itself -PRON- PRP cord-009101-376snefs 46 5 and and CC cord-009101-376snefs 46 6 releases release VBZ cord-009101-376snefs 46 7 new new JJ cord-009101-376snefs 46 8 virions virion NNS cord-009101-376snefs 46 9 into into IN cord-009101-376snefs 46 10 the the DT cord-009101-376snefs 46 11 interstitial interstitial JJ cord-009101-376snefs 46 12 space space NN cord-009101-376snefs 46 13 , , , cord-009101-376snefs 46 14 where where WRB cord-009101-376snefs 46 15 they -PRON- PRP cord-009101-376snefs 46 16 are be VBP cord-009101-376snefs 46 17 carried carry VBN cord-009101-376snefs 46 18 away away RB cord-009101-376snefs 46 19 via via IN cord-009101-376snefs 46 20 the the DT cord-009101-376snefs 46 21 lymphatics lymphatic NNS cord-009101-376snefs 46 22 or or CC cord-009101-376snefs 46 23 the the DT cord-009101-376snefs 46 24 bloodstream bloodstream NN cord-009101-376snefs 46 25 to to IN cord-009101-376snefs 46 26 secondary secondary JJ cord-009101-376snefs 46 27 foci foci NN cord-009101-376snefs 46 28 of of IN cord-009101-376snefs 46 29 infection infection NN cord-009101-376snefs 46 30 . . . cord-009101-376snefs 47 1 If if IN cord-009101-376snefs 47 2 tissue tissue NN cord-009101-376snefs 47 3 damage damage NN cord-009101-376snefs 47 4 occurs occur VBZ cord-009101-376snefs 47 5 at at IN cord-009101-376snefs 47 6 this this DT cord-009101-376snefs 47 7 point point NN cord-009101-376snefs 47 8 , , , cord-009101-376snefs 47 9 the the DT cord-009101-376snefs 47 10 inflammatory inflammatory JJ cord-009101-376snefs 47 11 and and CC cord-009101-376snefs 47 12 cell cell NN cord-009101-376snefs 47 13 - - HYPH cord-009101-376snefs 47 14 mediated mediate VBN cord-009101-376snefs 47 15 responses response NNS cord-009101-376snefs 47 16 are be VBP cord-009101-376snefs 47 17 activated activate VBN cord-009101-376snefs 47 18 . . . cord-009101-376snefs 48 1 Escaping escape VBG cord-009101-376snefs 48 2 virions virion NNS cord-009101-376snefs 48 3 in in IN cord-009101-376snefs 48 4 the the DT cord-009101-376snefs 48 5 bloodstream bloodstream NN cord-009101-376snefs 48 6 stimulate stimulate VBP cord-009101-376snefs 48 7 the the DT cord-009101-376snefs 48 8 production production NN cord-009101-376snefs 48 9 of of IN cord-009101-376snefs 48 10 circulating circulate VBG cord-009101-376snefs 48 11 IgM IgM NNP cord-009101-376snefs 48 12 and and CC cord-009101-376snefs 48 13 IgG IgG NNP cord-009101-376snefs 48 14 antibodies antibody NNS cord-009101-376snefs 48 15 . . . cord-009101-376snefs 49 1 IgM IgM NNP cord-009101-376snefs 49 2 tends tend VBZ cord-009101-376snefs 49 3 to to TO cord-009101-376snefs 49 4 be be VB cord-009101-376snefs 49 5 produced produce VBN cord-009101-376snefs 49 6 earlier early RBR cord-009101-376snefs 49 7 if if IN cord-009101-376snefs 49 8 the the DT cord-009101-376snefs 49 9 virus virus NN cord-009101-376snefs 49 10 is be VBZ cord-009101-376snefs 49 11 new new JJ cord-009101-376snefs 49 12 to to IN cord-009101-376snefs 49 13 the the DT cord-009101-376snefs 49 14 immune immune JJ cord-009101-376snefs 49 15 system system NN cord-009101-376snefs 49 16 , , , cord-009101-376snefs 49 17 whereas whereas IN cord-009101-376snefs 49 18 IgG IgG NNP cord-009101-376snefs 49 19 tends tend VBZ cord-009101-376snefs 49 20 to to TO cord-009101-376snefs 49 21 be be VB cord-009101-376snefs 49 22 produced produce VBN cord-009101-376snefs 49 23 first first RB cord-009101-376snefs 49 24 if if IN cord-009101-376snefs 49 25 the the DT cord-009101-376snefs 49 26 virus virus NN cord-009101-376snefs 49 27 is be VBZ cord-009101-376snefs 49 28 a a DT cord-009101-376snefs 49 29 repeat repeat NN cord-009101-376snefs 49 30 challenger challenger NN cord-009101-376snefs 49 31 . . . cord-009101-376snefs 50 1 The the DT cord-009101-376snefs 50 2 rise rise NN cord-009101-376snefs 50 3 in in IN cord-009101-376snefs 50 4 fetal fetal JJ cord-009101-376snefs 50 5 IgM igm NN cord-009101-376snefs 50 6 during during IN cord-009101-376snefs 50 7 intrauterine intrauterine JJ cord-009101-376snefs 50 8 infection infection NN cord-009101-376snefs 50 9 allows allow VBZ cord-009101-376snefs 50 10 fetal fetal JJ cord-009101-376snefs 50 11 or or CC cord-009101-376snefs 50 12 cord cord NN cord-009101-376snefs 50 13 blood blood NN cord-009101-376snefs 50 14 levels level NNS cord-009101-376snefs 50 15 to to TO cord-009101-376snefs 50 16 be be VB cord-009101-376snefs 50 17 used use VBN cord-009101-376snefs 50 18 in in IN cord-009101-376snefs 50 19 the the DT cord-009101-376snefs 50 20 diagnosis diagnosis NN cord-009101-376snefs 50 21 of of IN cord-009101-376snefs 50 22 congenital congenital JJ cord-009101-376snefs 50 23 viral viral JJ cord-009101-376snefs 50 24 infection infection NN cord-009101-376snefs 50 25 . . . cord-009101-376snefs 51 1 IgM IgM NNP cord-009101-376snefs 51 2 production production NN cord-009101-376snefs 51 3 peaks peak NNS cord-009101-376snefs 51 4 early early RB cord-009101-376snefs 51 5 in in IN cord-009101-376snefs 51 6 the the DT cord-009101-376snefs 51 7 infection infection NN cord-009101-376snefs 51 8 and and CC cord-009101-376snefs 51 9 rapidly rapidly RB cord-009101-376snefs 51 10 declines decline VBZ cord-009101-376snefs 51 11 . . . cord-009101-376snefs 52 1 IgG IgG NNP cord-009101-376snefs 52 2 peaks peak NNS cord-009101-376snefs 52 3 gradually gradually RB cord-009101-376snefs 52 4 and and CC cord-009101-376snefs 52 5 functions function NNS cord-009101-376snefs 52 6 longer long RBR cord-009101-376snefs 52 7 than than IN cord-009101-376snefs 52 8 IgM. IgM. NNP cord-009101-376snefs 53 1 Both both DT cord-009101-376snefs 53 2 of of IN cord-009101-376snefs 53 3 these these DT cord-009101-376snefs 53 4 immunoglobulins immunoglobulin NNS cord-009101-376snefs 53 5 attempt attempt VBP cord-009101-376snefs 53 6 to to TO cord-009101-376snefs 53 7 neutralize neutralize VB cord-009101-376snefs 53 8 the the DT cord-009101-376snefs 53 9 invading invade VBG cord-009101-376snefs 53 10 virus virus NN cord-009101-376snefs 53 11 by by IN cord-009101-376snefs 53 12 binding bind VBG cord-009101-376snefs 53 13 with with IN cord-009101-376snefs 53 14 the the DT cord-009101-376snefs 53 15 virus virus NN cord-009101-376snefs 53 16 to to TO cord-009101-376snefs 53 17 activate activate VB cord-009101-376snefs 53 18 complement complement NN cord-009101-376snefs 53 19 . . . cord-009101-376snefs 54 1 This this DT cord-009101-376snefs 54 2 mechanism mechanism NN cord-009101-376snefs 54 3 is be VBZ cord-009101-376snefs 54 4 designed design VBN cord-009101-376snefs 54 5 to to TO cord-009101-376snefs 54 6 prevent prevent VB cord-009101-376snefs 54 7 virus virus NN cord-009101-376snefs 54 8 absorption absorption NN cord-009101-376snefs 54 9 to to TO cord-009101-376snefs 54 10 host host NN cord-009101-376snefs 54 11 cells cell NNS cord-009101-376snefs 54 12 ( ( -LRB- cord-009101-376snefs 54 13 Overall Overall NNP cord-009101-376snefs 54 14 , , , cord-009101-376snefs 54 15 1992 1992 CD cord-009101-376snefs 54 16 ; ; : cord-009101-376snefs 54 17 Strodtbeck Strodtbeck NNP cord-009101-376snefs 54 18 , , , cord-009101-376snefs 54 19 1986 1986 CD cord-009101-376snefs 54 20 ) ) -RRB- cord-009101-376snefs 54 21 . . . cord-009101-376snefs 55 1 Once once IN cord-009101-376snefs 55 2 the the DT cord-009101-376snefs 55 3 virus virus NN cord-009101-376snefs 55 4 gains gain VBZ cord-009101-376snefs 55 5 entry entry NN cord-009101-376snefs 55 6 to to IN cord-009101-376snefs 55 7 the the DT cord-009101-376snefs 55 8 host host NN cord-009101-376snefs 55 9 cell cell NN cord-009101-376snefs 55 10 , , , cord-009101-376snefs 55 11 it -PRON- PRP cord-009101-376snefs 55 12 becomes become VBZ cord-009101-376snefs 55 13 the the DT cord-009101-376snefs 55 14 responsibility responsibility NN cord-009101-376snefs 55 15 of of IN cord-009101-376snefs 55 16 the the DT cord-009101-376snefs 55 17 cell cell NN cord-009101-376snefs 55 18 - - HYPH cord-009101-376snefs 55 19 mediated mediate VBN cord-009101-376snefs 55 20 system system NN cord-009101-376snefs 55 21 and and CC cord-009101-376snefs 55 22 the the DT cord-009101-376snefs 55 23 inflammatory inflammatory JJ cord-009101-376snefs 55 24 response response NN cord-009101-376snefs 55 25 to to TO cord-009101-376snefs 55 26 contain contain VB cord-009101-376snefs 55 27 the the DT cord-009101-376snefs 55 28 infection infection NN cord-009101-376snefs 55 29 . . . cord-009101-376snefs 56 1 Infected infected JJ cord-009101-376snefs 56 2 host host NN cord-009101-376snefs 56 3 cells cell NNS cord-009101-376snefs 56 4 develop develop VBP cord-009101-376snefs 56 5 new new JJ cord-009101-376snefs 56 6 virus virus NN cord-009101-376snefs 56 7 - - HYPH cord-009101-376snefs 56 8 induced induce VBN cord-009101-376snefs 56 9 , , , cord-009101-376snefs 56 10 antigenic antigenic JJ cord-009101-376snefs 56 11 determinants determinant NNS cord-009101-376snefs 56 12 on on IN cord-009101-376snefs 56 13 their -PRON- PRP$ cord-009101-376snefs 56 14 cell cell NN cord-009101-376snefs 56 15 membranes membrane NNS cord-009101-376snefs 56 16 that that WDT cord-009101-376snefs 56 17 alert alert VBP cord-009101-376snefs 56 18 these these DT cord-009101-376snefs 56 19 defenses defense NNS cord-009101-376snefs 56 20 . . . cord-009101-376snefs 57 1 The the DT cord-009101-376snefs 57 2 new new JJ cord-009101-376snefs 57 3 antigens antigen NNS cord-009101-376snefs 57 4 trigger trigger NN cord-009101-376snefs 57 5 T t NN cord-009101-376snefs 57 6 lymphocytes lymphocyte NNS cord-009101-376snefs 57 7 to to TO cord-009101-376snefs 57 8 respond respond VB cord-009101-376snefs 57 9 along along IN cord-009101-376snefs 57 10 with with IN cord-009101-376snefs 57 11 macrophages macrophage NNS cord-009101-376snefs 57 12 and and CC cord-009101-376snefs 57 13 other other JJ cord-009101-376snefs 57 14 components component NNS cord-009101-376snefs 57 15 of of IN cord-009101-376snefs 57 16 the the DT cord-009101-376snefs 57 17 immune immune JJ cord-009101-376snefs 57 18 system system NN cord-009101-376snefs 57 19 ( ( -LRB- cord-009101-376snefs 57 20 Overall Overall NNP cord-009101-376snefs 57 21 , , , cord-009101-376snefs 57 22 1992 1992 CD cord-009101-376snefs 57 23 ; ; : cord-009101-376snefs 57 24 Strodtbeck Strodtbeck NNP cord-009101-376snefs 57 25 , , , cord-009101-376snefs 57 26 1986 1986 CD cord-009101-376snefs 57 27 ) ) -RRB- cord-009101-376snefs 57 28 . . . cord-009101-376snefs 58 1 Activation activation NN cord-009101-376snefs 58 2 of of IN cord-009101-376snefs 58 3 the the DT cord-009101-376snefs 58 4 immune immune JJ cord-009101-376snefs 58 5 response response NN cord-009101-376snefs 58 6 at at IN cord-009101-376snefs 58 7 this this DT cord-009101-376snefs 58 8 point point NN cord-009101-376snefs 58 9 may may MD cord-009101-376snefs 58 10 result result VB cord-009101-376snefs 58 11 in in IN cord-009101-376snefs 58 12 the the DT cord-009101-376snefs 58 13 destruction destruction NN cord-009101-376snefs 58 14 of of IN cord-009101-376snefs 58 15 some some DT cord-009101-376snefs 58 16 host host NN cord-009101-376snefs 58 17 cells cell NNS cord-009101-376snefs 58 18 , , , cord-009101-376snefs 58 19 rather rather RB cord-009101-376snefs 58 20 than than IN cord-009101-376snefs 58 21 the the DT cord-009101-376snefs 58 22 virus virus NN cord-009101-376snefs 58 23 , , , cord-009101-376snefs 58 24 by by IN cord-009101-376snefs 58 25 the the DT cord-009101-376snefs 58 26 immune immune JJ cord-009101-376snefs 58 27 system system NN cord-009101-376snefs 58 28 . . . cord-009101-376snefs 59 1 In in IN cord-009101-376snefs 59 2 the the DT cord-009101-376snefs 59 3 developing develop VBG cord-009101-376snefs 59 4 fetus fetus NN cord-009101-376snefs 59 5 , , , cord-009101-376snefs 59 6 this this DT cord-009101-376snefs 59 7 can can MD cord-009101-376snefs 59 8 worsen worsen VB cord-009101-376snefs 59 9 the the DT cord-009101-376snefs 59 10 severity severity NN cord-009101-376snefs 59 11 of of IN cord-009101-376snefs 59 12 birth birth NN cord-009101-376snefs 59 13 defects defect NNS cord-009101-376snefs 59 14 associated associate VBN cord-009101-376snefs 59 15 with with IN cord-009101-376snefs 59 16 specific specific JJ cord-009101-376snefs 59 17 viral viral JJ cord-009101-376snefs 59 18 diseases disease NNS cord-009101-376snefs 59 19 , , , cord-009101-376snefs 59 20 such such JJ cord-009101-376snefs 59 21 as as IN cord-009101-376snefs 59 22 rubella rubella NN cord-009101-376snefs 59 23 or or CC cord-009101-376snefs 59 24 cytomegalovirus cytomegalovirus NN cord-009101-376snefs 59 25 ( ( -LRB- cord-009101-376snefs 59 26 CMV CMV NNP cord-009101-376snefs 59 27 ) ) -RRB- cord-009101-376snefs 59 28 . . . cord-009101-376snefs 60 1 For for IN cord-009101-376snefs 60 2 example example NN cord-009101-376snefs 60 3 , , , cord-009101-376snefs 60 4 neurons neuron NNS cord-009101-376snefs 60 5 coated coat VBN cord-009101-376snefs 60 6 with with IN cord-009101-376snefs 60 7 CMV CMV NNP cord-009101-376snefs 60 8 may may MD cord-009101-376snefs 60 9 be be VB cord-009101-376snefs 60 10 destroyed destroy VBN cord-009101-376snefs 60 11 by by IN cord-009101-376snefs 60 12 lymphocytes lymphocyte NNS cord-009101-376snefs 60 13 which which WDT cord-009101-376snefs 60 14 , , , cord-009101-376snefs 60 15 when when WRB cord-009101-376snefs 60 16 added add VBN cord-009101-376snefs 60 17 to to IN cord-009101-376snefs 60 18 the the DT cord-009101-376snefs 60 19 number number NN cord-009101-376snefs 60 20 of of IN cord-009101-376snefs 60 21 neurons neuron NNS cord-009101-376snefs 60 22 undergoing undergo VBG cord-009101-376snefs 60 23 viral viral JJ cord-009101-376snefs 60 24 lysis lysis NN cord-009101-376snefs 60 25 , , , cord-009101-376snefs 60 26 increases increase VBZ cord-009101-376snefs 60 27 the the DT cord-009101-376snefs 60 28 risk risk NN cord-009101-376snefs 60 29 for for IN cord-009101-376snefs 60 30 microcephaly microcephaly NNS cord-009101-376snefs 60 31 . . . cord-009101-376snefs 61 1 Antigen antigen NN cord-009101-376snefs 61 2 - - HYPH cord-009101-376snefs 61 3 antibody antibody NN cord-009101-376snefs 61 4 complexes complex NNS cord-009101-376snefs 61 5 also also RB cord-009101-376snefs 61 6 are be VBP cord-009101-376snefs 61 7 formed form VBN cord-009101-376snefs 61 8 that that WDT cord-009101-376snefs 61 9 liberate liberate VBP cord-009101-376snefs 61 10 chemotactic chemotactic JJ cord-009101-376snefs 61 11 factors factor NNS cord-009101-376snefs 61 12 and and CC cord-009101-376snefs 61 13 cytokines cytokine NNS cord-009101-376snefs 61 14 . . . cord-009101-376snefs 62 1 Histamine histamine NN cord-009101-376snefs 62 2 and and CC cord-009101-376snefs 62 3 kinin kinin NN cord-009101-376snefs 62 4 release release NN cord-009101-376snefs 62 5 results result NNS cord-009101-376snefs 62 6 in in IN cord-009101-376snefs 62 7 vasodilation vasodilation NN cord-009101-376snefs 62 8 , , , cord-009101-376snefs 62 9 heat heat NN cord-009101-376snefs 62 10 production production NN cord-009101-376snefs 62 11 , , , cord-009101-376snefs 62 12 and and CC cord-009101-376snefs 62 13 increased increase VBD cord-009101-376snefs 62 14 capillary capillary JJ cord-009101-376snefs 62 15 permeability permeability NN cord-009101-376snefs 62 16 . . . cord-009101-376snefs 63 1 This this DT cord-009101-376snefs 63 2 results result VBZ cord-009101-376snefs 63 3 in in IN cord-009101-376snefs 63 4 increased increase VBN cord-009101-376snefs 63 5 temperature temperature NN cord-009101-376snefs 63 6 ( ( -LRB- cord-009101-376snefs 63 7 fever fever NN cord-009101-376snefs 63 8 ) ) -RRB- cord-009101-376snefs 63 9 and and CC cord-009101-376snefs 63 10 stagnant stagnant JJ cord-009101-376snefs 63 11 anoxia anoxia NN cord-009101-376snefs 63 12 locally locally RB cord-009101-376snefs 63 13 , , , cord-009101-376snefs 63 14 which which WDT cord-009101-376snefs 63 15 decreases decrease VBZ cord-009101-376snefs 63 16 absorption absorption NN cord-009101-376snefs 63 17 of of IN cord-009101-376snefs 63 18 the the DT cord-009101-376snefs 63 19 virus virus NN cord-009101-376snefs 63 20 because because IN cord-009101-376snefs 63 21 most most JJS cord-009101-376snefs 63 22 viruses virus NNS cord-009101-376snefs 63 23 are be VBP cord-009101-376snefs 63 24 susceptible susceptible JJ cord-009101-376snefs 63 25 to to IN cord-009101-376snefs 63 26 increased increase VBN cord-009101-376snefs 63 27 temperature temperature NN cord-009101-376snefs 63 28 and and CC cord-009101-376snefs 63 29 acidic acidic JJ cord-009101-376snefs 63 30 environments environment NNS cord-009101-376snefs 63 31 ( ( -LRB- cord-009101-376snefs 63 32 Strodtbeck Strodtbeck NNP cord-009101-376snefs 63 33 , , , cord-009101-376snefs 63 34 1986 1986 CD cord-009101-376snefs 63 35 ; ; : cord-009101-376snefs 63 36 Voyles Voyles NNP cord-009101-376snefs 63 37 , , , cord-009101-376snefs 63 38 1993 1993 CD cord-009101-376snefs 63 39 ) ) -RRB- cord-009101-376snefs 63 40 . . . cord-009101-376snefs 64 1 A a DT cord-009101-376snefs 64 2 side side JJ cord-009101-376snefs 64 3 effect effect NN cord-009101-376snefs 64 4 of of IN cord-009101-376snefs 64 5 this this DT cord-009101-376snefs 64 6 process process NN cord-009101-376snefs 64 7 is be VBZ cord-009101-376snefs 64 8 a a DT cord-009101-376snefs 64 9 less less JJR cord-009101-376snefs 64 10 - - HYPH cord-009101-376snefs 64 11 than than IN cord-009101-376snefs 64 12 - - HYPH cord-009101-376snefs 64 13 ideal ideal JJ cord-009101-376snefs 64 14 environment environment NN cord-009101-376snefs 64 15 for for IN cord-009101-376snefs 64 16 the the DT cord-009101-376snefs 64 17 growth growth NN cord-009101-376snefs 64 18 of of IN cord-009101-376snefs 64 19 healthy healthy JJ cord-009101-376snefs 64 20 tissue tissue NN cord-009101-376snefs 64 21 . . . cord-009101-376snefs 65 1 The the DT cord-009101-376snefs 65 2 final final JJ cord-009101-376snefs 65 3 consideration consideration NN cord-009101-376snefs 65 4 in in IN cord-009101-376snefs 65 5 the the DT cord-009101-376snefs 65 6 newborn newborn NN cord-009101-376snefs 65 7 's 's POS cord-009101-376snefs 65 8 response response NN cord-009101-376snefs 65 9 to to IN cord-009101-376snefs 65 10 viral viral JJ cord-009101-376snefs 65 11 infection infection NN cord-009101-376snefs 65 12 is be VBZ cord-009101-376snefs 65 13 the the DT cord-009101-376snefs 65 14 production production NN cord-009101-376snefs 65 15 of of IN cord-009101-376snefs 65 16 interferon interferon NN cord-009101-376snefs 65 17 . . . cord-009101-376snefs 66 1 Interferons interferon NNS cord-009101-376snefs 66 2 are be VBP cord-009101-376snefs 66 3 highly highly RB cord-009101-376snefs 66 4 active active JJ cord-009101-376snefs 66 5 proteins protein NNS cord-009101-376snefs 66 6 produced produce VBN cord-009101-376snefs 66 7 by by IN cord-009101-376snefs 66 8 virus virus NN cord-009101-376snefs 66 9 - - HYPH cord-009101-376snefs 66 10 infected infect VBN cord-009101-376snefs 66 11 cells cell NNS cord-009101-376snefs 66 12 that that WDT cord-009101-376snefs 66 13 act act VBP cord-009101-376snefs 66 14 upon upon IN cord-009101-376snefs 66 15 neighboring neighboring NN cord-009101-376snefs 66 16 cells cell NNS cord-009101-376snefs 66 17 to to TO cord-009101-376snefs 66 18 prevent prevent VB cord-009101-376snefs 66 19 the the DT cord-009101-376snefs 66 20 spread spread NN cord-009101-376snefs 66 21 of of IN cord-009101-376snefs 66 22 the the DT cord-009101-376snefs 66 23 viral viral JJ cord-009101-376snefs 66 24 infection infection NN cord-009101-376snefs 66 25 . . . cord-009101-376snefs 67 1 They -PRON- PRP cord-009101-376snefs 67 2 also also RB cord-009101-376snefs 67 3 are be VBP cord-009101-376snefs 67 4 produced produce VBN cord-009101-376snefs 67 5 by by IN cord-009101-376snefs 67 6 cells cell NNS cord-009101-376snefs 67 7 of of IN cord-009101-376snefs 67 8 the the DT cord-009101-376snefs 67 9 immune immune JJ cord-009101-376snefs 67 10 system system NN cord-009101-376snefs 67 11 . . . cord-009101-376snefs 68 1 Interferons interferon NNS cord-009101-376snefs 68 2 disrupt disrupt VBP cord-009101-376snefs 68 3 viral viral JJ cord-009101-376snefs 68 4 infectivity infectivity NN cord-009101-376snefs 68 5 in in IN cord-009101-376snefs 68 6 a a DT cord-009101-376snefs 68 7 variety variety NN cord-009101-376snefs 68 8 of of IN cord-009101-376snefs 68 9 ways way NNS cord-009101-376snefs 68 10 that that WDT cord-009101-376snefs 68 11 are be VBP cord-009101-376snefs 68 12 still still RB cord-009101-376snefs 68 13 being be VBG cord-009101-376snefs 68 14 studied study VBN cord-009101-376snefs 68 15 . . . cord-009101-376snefs 69 1 Newborn newborn JJ cord-009101-376snefs 69 2 interferon interferon NN cord-009101-376snefs 69 3 production production NN cord-009101-376snefs 69 4 appears appear VBZ cord-009101-376snefs 69 5 to to TO cord-009101-376snefs 69 6 be be VB cord-009101-376snefs 69 7 decreased decrease VBN cord-009101-376snefs 69 8 via via IN cord-009101-376snefs 69 9 one one CD cord-009101-376snefs 69 10 pathway pathway NN cord-009101-376snefs 69 11 and and CC cord-009101-376snefs 69 12 normal normal JJ cord-009101-376snefs 69 13 via via IN cord-009101-376snefs 69 14 the the DT cord-009101-376snefs 69 15 other other JJ cord-009101-376snefs 69 16 ( ( -LRB- cord-009101-376snefs 69 17 Strodtbeck Strodtbeck NNP cord-009101-376snefs 69 18 , , , cord-009101-376snefs 69 19 1986 1986 CD cord-009101-376snefs 69 20 ) ) -RRB- cord-009101-376snefs 69 21 . . . cord-009101-376snefs 70 1 Despite despite IN cord-009101-376snefs 70 2 the the DT cord-009101-376snefs 70 3 deficiencies deficiency NNS cord-009101-376snefs 70 4 of of IN cord-009101-376snefs 70 5 the the DT cord-009101-376snefs 70 6 newborn newborn JJ cord-009101-376snefs 70 7 immune immune JJ cord-009101-376snefs 70 8 system system NN cord-009101-376snefs 70 9 to to IN cord-009101-376snefs 70 10 viral viral JJ cord-009101-376snefs 70 11 attack attack NN cord-009101-376snefs 70 12 , , , cord-009101-376snefs 70 13 only only RB cord-009101-376snefs 70 14 a a DT cord-009101-376snefs 70 15 few few JJ cord-009101-376snefs 70 16 of of IN cord-009101-376snefs 70 17 the the DT cord-009101-376snefs 70 18 hundreds hundred NNS cord-009101-376snefs 70 19 of of IN cord-009101-376snefs 70 20 viruses virus NNS cord-009101-376snefs 70 21 known know VBN cord-009101-376snefs 70 22 to to TO cord-009101-376snefs 70 23 cause cause VB cord-009101-376snefs 70 24 human human JJ cord-009101-376snefs 70 25 disease disease NN cord-009101-376snefs 70 26 actually actually RB cord-009101-376snefs 70 27 result result VBP cord-009101-376snefs 70 28 in in IN cord-009101-376snefs 70 29 infection infection NN cord-009101-376snefs 70 30 of of IN cord-009101-376snefs 70 31 the the DT cord-009101-376snefs 70 32 fetus fetus NN cord-009101-376snefs 70 33 or or CC cord-009101-376snefs 70 34 newborn newborn JJ cord-009101-376snefs 70 35 ( ( -LRB- cord-009101-376snefs 70 36 Overall Overall NNP cord-009101-376snefs 70 37 , , , cord-009101-376snefs 70 38 1992 1992 CD cord-009101-376snefs 70 39 ) ) -RRB- cord-009101-376snefs 70 40 . . . cord-009101-376snefs 71 1 Viral viral JJ cord-009101-376snefs 71 2 infection infection NN cord-009101-376snefs 71 3 of of IN cord-009101-376snefs 71 4 the the DT cord-009101-376snefs 71 5 newborn newborn NN cord-009101-376snefs 71 6 usually usually RB cord-009101-376snefs 71 7 is be VBZ cord-009101-376snefs 71 8 classified classify VBN cord-009101-376snefs 71 9 as as IN cord-009101-376snefs 71 10 congenital congenital JJ cord-009101-376snefs 71 11 , , , cord-009101-376snefs 71 12 acquired acquire VBN cord-009101-376snefs 71 13 , , , cord-009101-376snefs 71 14 or or CC cord-009101-376snefs 71 15 nosocomial nosocomial JJ cord-009101-376snefs 71 16 ( ( -LRB- cord-009101-376snefs 71 17 hospital hospital NN cord-009101-376snefs 71 18 - - HYPH cord-009101-376snefs 71 19 acquired acquire VBN cord-009101-376snefs 71 20 ) ) -RRB- cord-009101-376snefs 71 21 in in IN cord-009101-376snefs 71 22 origin origin NN cord-009101-376snefs 71 23 . . . cord-009101-376snefs 72 1 Congenital congenital JJ cord-009101-376snefs 72 2 viral viral JJ cord-009101-376snefs 72 3 infections infection NNS cord-009101-376snefs 72 4 occur occur VBP cord-009101-376snefs 72 5 when when WRB cord-009101-376snefs 72 6 an an DT cord-009101-376snefs 72 7 infected infected JJ cord-009101-376snefs 72 8 mother mother NN cord-009101-376snefs 72 9 transmits transmit VBZ cord-009101-376snefs 72 10 the the DT cord-009101-376snefs 72 11 virus virus NN cord-009101-376snefs 72 12 across across IN cord-009101-376snefs 72 13 the the DT cord-009101-376snefs 72 14 placenta placenta NN cord-009101-376snefs 72 15 to to IN cord-009101-376snefs 72 16 the the DT cord-009101-376snefs 72 17 fetus fetus NN cord-009101-376snefs 72 18 . . . cord-009101-376snefs 73 1 Theoretically theoretically RB cord-009101-376snefs 73 2 , , , cord-009101-376snefs 73 3 all all DT cord-009101-376snefs 73 4 viruses virus NNS cord-009101-376snefs 73 5 are be VBP cord-009101-376snefs 73 6 capable capable JJ cord-009101-376snefs 73 7 of of IN cord-009101-376snefs 73 8 causing cause VBG cord-009101-376snefs 73 9 congenital congenital JJ cord-009101-376snefs 73 10 infections infection NNS cord-009101-376snefs 73 11 , , , cord-009101-376snefs 73 12 but but CC cord-009101-376snefs 73 13 most most JJS cord-009101-376snefs 73 14 do do VBP cord-009101-376snefs 73 15 not not RB cord-009101-376snefs 73 16 ( ( -LRB- cord-009101-376snefs 73 17 Overall Overall NNP cord-009101-376snefs 73 18 , , , cord-009101-376snefs 73 19 1992 1992 CD cord-009101-376snefs 73 20 ) ) -RRB- cord-009101-376snefs 73 21 . . . cord-009101-376snefs 74 1 This this DT cord-009101-376snefs 74 2 may may MD cord-009101-376snefs 74 3 be be VB cord-009101-376snefs 74 4 attributable attributable JJ cord-009101-376snefs 74 5 in in IN cord-009101-376snefs 74 6 part part NN cord-009101-376snefs 74 7 to to IN cord-009101-376snefs 74 8 maternal maternal JJ cord-009101-376snefs 74 9 and and CC cord-009101-376snefs 74 10 placental placental JJ cord-009101-376snefs 74 11 immune immune JJ cord-009101-376snefs 74 12 defenses defense NNS cord-009101-376snefs 74 13 that that WDT cord-009101-376snefs 74 14 protect protect VBP cord-009101-376snefs 74 15 the the DT cord-009101-376snefs 74 16 fetus fetus NN cord-009101-376snefs 74 17 or or CC cord-009101-376snefs 74 18 to to IN cord-009101-376snefs 74 19 the the DT cord-009101-376snefs 74 20 nature nature NN cord-009101-376snefs 75 1 o o UH cord-009101-376snefs 75 2 f f NFP cord-009101-376snefs 75 3 the the DT cord-009101-376snefs 75 4 maternal maternal JJ cord-009101-376snefs 75 5 illness illness NN cord-009101-376snefs 75 6 . . . cord-009101-376snefs 76 1 Most Most JJS cord-009101-376snefs 76 2 viral viral JJ cord-009101-376snefs 76 3 infections infection NNS cord-009101-376snefs 76 4 in in IN cord-009101-376snefs 76 5 pregnancy pregnancy NN cord-009101-376snefs 76 6 are be VBP cord-009101-376snefs 76 7 mild mild JJ cord-009101-376snefs 76 8 respiratory respiratory JJ cord-009101-376snefs 76 9 or or CC cord-009101-376snefs 76 10 gastrointestinal gastrointestinal JJ cord-009101-376snefs 76 11 infections infection NNS cord-009101-376snefs 76 12 that that WDT cord-009101-376snefs 76 13 do do VBP cord-009101-376snefs 76 14 not not RB cord-009101-376snefs 76 15 pose pose VB cord-009101-376snefs 76 16 a a DT cord-009101-376snefs 76 17 serious serious JJ cord-009101-376snefs 76 18 threat threat NN cord-009101-376snefs 76 19 to to IN cord-009101-376snefs 76 20 the the DT cord-009101-376snefs 76 21 health health NN cord-009101-376snefs 76 22 of of IN cord-009101-376snefs 76 23 the the DT cord-009101-376snefs 76 24 fetus fetus NN cord-009101-376snefs 76 25 ( ( -LRB- cord-009101-376snefs 76 26 Overall Overall NNP cord-009101-376snefs 76 27 , , , cord-009101-376snefs 76 28 1992 1992 CD cord-009101-376snefs 76 29 ) ) -RRB- cord-009101-376snefs 76 30 . . . cord-009101-376snefs 77 1 The the DT cord-009101-376snefs 77 2 viruses virus NNS cord-009101-376snefs 77 3 implicated implicate VBN cord-009101-376snefs 77 4 in in IN cord-009101-376snefs 77 5 congenital congenital JJ cord-009101-376snefs 77 6 infection infection NN cord-009101-376snefs 77 7 are be VBP cord-009101-376snefs 77 8 cytomegalovirus cytomegalovirus NN cord-009101-376snefs 77 9 , , , cord-009101-376snefs 77 10 herpes herpes NN cord-009101-376snefs 77 11 simplex simplex NN cord-009101-376snefs 77 12 virus virus NN cord-009101-376snefs 77 13 , , , cord-009101-376snefs 77 14 rubella rubella NN cord-009101-376snefs 77 15 ( ( -LRB- cord-009101-376snefs 77 16 German german JJ cord-009101-376snefs 77 17 measles measle NNS cord-009101-376snefs 77 18 ) ) -RRB- cord-009101-376snefs 77 19 , , , cord-009101-376snefs 77 20 and and CC cord-009101-376snefs 77 21 varicella varicella NN cord-009101-376snefs 77 22 ( ( -LRB- cord-009101-376snefs 77 23 chickenpox chickenpox NN cord-009101-376snefs 77 24 ) ) -RRB- cord-009101-376snefs 77 25 ( ( -LRB- cord-009101-376snefs 77 26 Overall Overall NNP cord-009101-376snefs 77 27 , , , cord-009101-376snefs 77 28 1992 1992 CD cord-009101-376snefs 77 29 ; ; : cord-009101-376snefs 77 30 Smith Smith NNP cord-009101-376snefs 77 31 , , , cord-009101-376snefs 77 32 1993 1993 CD cord-009101-376snefs 77 33 ) ) -RRB- cord-009101-376snefs 77 34 . . . cord-009101-376snefs 78 1 There there EX cord-009101-376snefs 78 2 is be VBZ cord-009101-376snefs 78 3 debate debate NN cord-009101-376snefs 78 4 within within IN cord-009101-376snefs 78 5 the the DT cord-009101-376snefs 78 6 medical medical JJ cord-009101-376snefs 78 7 community community NN cord-009101-376snefs 78 8 about about IN cord-009101-376snefs 78 9 a a DT cord-009101-376snefs 78 10 congenital congenital JJ cord-009101-376snefs 78 11 viral viral JJ cord-009101-376snefs 78 12 syndrome syndrome NN cord-009101-376snefs 78 13 caused cause VBN cord-009101-376snefs 78 14 by by IN cord-009101-376snefs 78 15 the the DT cord-009101-376snefs 78 16 human human JJ cord-009101-376snefs 78 17 immunodeficiency immunodeficiency NN cord-009101-376snefs 78 18 virus virus NN cord-009101-376snefs 78 19 ( ( -LRB- cord-009101-376snefs 78 20 HIV HIV NNP cord-009101-376snefs 78 21 ) ) -RRB- cord-009101-376snefs 78 22 . . . cord-009101-376snefs 79 1 Acquired acquire VBN cord-009101-376snefs 79 2 viral viral JJ cord-009101-376snefs 79 3 infections infection NNS cord-009101-376snefs 79 4 occur occur VBP cord-009101-376snefs 79 5 after after IN cord-009101-376snefs 79 6 exposure exposure NN cord-009101-376snefs 79 7 of of IN cord-009101-376snefs 79 8 the the DT cord-009101-376snefs 79 9 newborn newborn JJ cord-009101-376snefs 79 10 t t NN cord-009101-376snefs 79 11 o o NNP cord-009101-376snefs 79 12 maternal maternal JJ cord-009101-376snefs 79 13 vaginal vaginal JJ cord-009101-376snefs 79 14 tract tract NN cord-009101-376snefs 79 15 flora flora NNS cord-009101-376snefs 79 16 and and CC cord-009101-376snefs 79 17 breast breast NN cord-009101-376snefs 79 18 milk milk NN cord-009101-376snefs 79 19 . . . cord-009101-376snefs 80 1 Genital genital JJ cord-009101-376snefs 80 2 secretions secretion NNS cord-009101-376snefs 80 3 may may MD cord-009101-376snefs 80 4 be be VB cord-009101-376snefs 80 5 contaminated contaminate VBN cord-009101-376snefs 80 6 with with IN cord-009101-376snefs 80 7 CMV CMV NNP cord-009101-376snefs 80 8 , , , cord-009101-376snefs 80 9 enteroviruses enteroviruses NNP cord-009101-376snefs 80 10 , , , cord-009101-376snefs 80 11 hepatitis hepatitis NNP cord-009101-376snefs 80 12 B B NNP cord-009101-376snefs 80 13 virus virus NN cord-009101-376snefs 80 14 , , , cord-009101-376snefs 80 15 and and CC cord-009101-376snefs 80 16 herpes herpes NN cord-009101-376snefs 80 17 simplex simplex NNP cord-009101-376snefs 80 18 virus virus NN cord-009101-376snefs 80 19 . . . cord-009101-376snefs 81 1 Contaminated contaminate VBN cord-009101-376snefs 81 2 breast breast NN cord-009101-376snefs 81 3 milk milk NN cord-009101-376snefs 81 4 has have VBZ cord-009101-376snefs 81 5 been be VBN cord-009101-376snefs 81 6 implicated implicate VBN cord-009101-376snefs 81 7 in in IN cord-009101-376snefs 81 8 newborn newborn JJ cord-009101-376snefs 81 9 infection infection NN cord-009101-376snefs 81 10 with with IN cord-009101-376snefs 81 11 HIV HIV NNP cord-009101-376snefs 81 12 , , , cord-009101-376snefs 81 13 herpes herpes NN cord-009101-376snefs 81 14 simplex simplex NN cord-009101-376snefs 81 15 , , , cord-009101-376snefs 81 16 and and CC cord-009101-376snefs 81 17 other other JJ cord-009101-376snefs 81 18 viruses virus NNS cord-009101-376snefs 81 19 ( ( -LRB- cord-009101-376snefs 81 20 Overall Overall NNP cord-009101-376snefs 81 21 , , , cord-009101-376snefs 81 22 1992 1992 CD cord-009101-376snefs 81 23 ) ) -RRB- cord-009101-376snefs 81 24 . . . cord-009101-376snefs 82 1 Nosocomial nosocomial JJ cord-009101-376snefs 82 2 viral viral JJ cord-009101-376snefs 82 3 infections infection NNS cord-009101-376snefs 82 4 may may MD cord-009101-376snefs 82 5 be be VB cord-009101-376snefs 82 6 acquired acquire VBN cord-009101-376snefs 82 7 in in IN cord-009101-376snefs 82 8 the the DT cord-009101-376snefs 82 9 newborn newborn JJ cord-009101-376snefs 82 10 nursery nursery NN cord-009101-376snefs 82 11 or or CC cord-009101-376snefs 82 12 the the DT cord-009101-376snefs 82 13 intensive intensive JJ cord-009101-376snefs 82 14 care care NN cord-009101-376snefs 82 15 nursery nursery NN cord-009101-376snefs 82 16 ( ( -LRB- cord-009101-376snefs 82 17 Guerina Guerina NNP cord-009101-376snefs 82 18 8r 8r NNP cord-009101-376snefs 82 19 Goldmann Goldmann NNP cord-009101-376snefs 82 20 , , , cord-009101-376snefs 82 21 1993 1993 CD cord-009101-376snefs 82 22 ; ; : cord-009101-376snefs 82 23 Strodtbeck Strodtbeck NNP cord-009101-376snefs 82 24 , , , cord-009101-376snefs 82 25 1986 1986 CD cord-009101-376snefs 82 26 ) ) -RRB- cord-009101-376snefs 82 27 . . . cord-009101-376snefs 83 1 Current current JJ cord-009101-376snefs 83 2 trends trend NNS cord-009101-376snefs 83 3 of of IN cord-009101-376snefs 83 4 short short JJ cord-009101-376snefs 83 5 length length NN cord-009101-376snefs 83 6 of of IN cord-009101-376snefs 83 7 stay stay NN cord-009101-376snefs 83 8 and and CC cord-009101-376snefs 83 9 rooming room VBG cord-009101-376snefs 83 10 in in IN cord-009101-376snefs 83 11 minimize minimize VB cord-009101-376snefs 83 12 the the DT cord-009101-376snefs 83 13 risk risk NN cord-009101-376snefs 83 14 of of IN cord-009101-376snefs 83 15 hospital hospital NN cord-009101-376snefs 83 16 - - HYPH cord-009101-376snefs 83 17 acquired acquire VBN cord-009101-376snefs 83 18 infection infection NN cord-009101-376snefs 83 19 in in IN cord-009101-376snefs 83 20 the the DT cord-009101-376snefs 83 21 healthy healthy JJ cord-009101-376snefs 83 22 infant infant NN cord-009101-376snefs 83 23 assigned assign VBN cord-009101-376snefs 83 24 to to IN cord-009101-376snefs 83 25 the the DT cord-009101-376snefs 83 26 newborn newborn JJ cord-009101-376snefs 83 27 nursery nursery NN cord-009101-376snefs 83 28 . . . cord-009101-376snefs 84 1 High high JJ cord-009101-376snefs 84 2 - - HYPH cord-009101-376snefs 84 3 risk risk NN cord-009101-376snefs 84 4 or or CC cord-009101-376snefs 84 5 premature premature JJ cord-009101-376snefs 84 6 infants infant NNS cord-009101-376snefs 84 7 transferred transfer VBN cord-009101-376snefs 84 8 to to IN cord-009101-376snefs 84 9 the the DT cord-009101-376snefs 84 10 intensive intensive JJ cord-009101-376snefs 84 11 care care NN cord-009101-376snefs 84 12 nursery nursery NN cord-009101-376snefs 84 13 are be VBP cord-009101-376snefs 84 14 at at IN cord-009101-376snefs 84 15 risk risk NN cord-009101-376snefs 84 16 for for IN cord-009101-376snefs 84 17 nosocomial nosocomial JJ cord-009101-376snefs 84 18 viral viral JJ cord-009101-376snefs 84 19 infections infection NNS cord-009101-376snefs 84 20 from from IN cord-009101-376snefs 84 21 members member NNS cord-009101-376snefs 84 22 of of IN cord-009101-376snefs 84 23 their -PRON- PRP$ cord-009101-376snefs 84 24 family family NN cord-009101-376snefs 84 25 , , , cord-009101-376snefs 84 26 health health NN cord-009101-376snefs 84 27 care care NN cord-009101-376snefs 84 28 providers provider NNS cord-009101-376snefs 84 29 , , , cord-009101-376snefs 84 30 other other JJ cord-009101-376snefs 84 31 infants infant NNS cord-009101-376snefs 84 32 , , , cord-009101-376snefs 84 33 treatment treatment NN cord-009101-376snefs 84 34 therapies therapy NNS cord-009101-376snefs 84 35 ( ( -LRB- cord-009101-376snefs 84 36 such such JJ cord-009101-376snefs 84 37 as as IN cord-009101-376snefs 84 38 blood blood NN cord-009101-376snefs 84 39 transfusions transfusion NNS cord-009101-376snefs 84 40 ) ) -RRB- cord-009101-376snefs 84 41 , , , cord-009101-376snefs 84 42 or or CC cord-009101-376snefs 84 43 contaminated contaminate VBN cord-009101-376snefs 84 44 objects object NNS cord-009101-376snefs 84 45 ( ( -LRB- cord-009101-376snefs 84 46 fomites fomite NNS cord-009101-376snefs 84 47 ) ) -RRB- cord-009101-376snefs 84 48 in in IN cord-009101-376snefs 84 49 the the DT cord-009101-376snefs 84 50 environment environment NN cord-009101-376snefs 84 51 . . . cord-009101-376snefs 85 1 Specific specific JJ cord-009101-376snefs 85 2 features feature VBZ cord-009101-376snefs 85 3 about about IN cord-009101-376snefs 85 4 the the DT cord-009101-376snefs 85 5 most most RBS cord-009101-376snefs 85 6 common common JJ cord-009101-376snefs 85 7 viral viral JJ cord-009101-376snefs 85 8 infections infection NNS cord-009101-376snefs 85 9 of of IN cord-009101-376snefs 85 10 concern concern NN cord-009101-376snefs 85 11 to to IN cord-009101-376snefs 85 12 the the DT cord-009101-376snefs 85 13 newborn newborn NN cord-009101-376snefs 85 14 are be VBP cord-009101-376snefs 85 15 summarized summarize VBN cord-009101-376snefs 85 16 in in IN cord-009101-376snefs 85 17 Table Table NNP cord-009101-376snefs 85 18 _SP cord-009101-376snefs 85 19 1 1 CD cord-009101-376snefs 85 20 . . . cord-009101-376snefs 86 1 Pertinent pertinent JJ cord-009101-376snefs 86 2 information information NN cord-009101-376snefs 86 3 on on IN cord-009101-376snefs 86 4 the the DT cord-009101-376snefs 86 5 incidence incidence NN cord-009101-376snefs 86 6 , , , cord-009101-376snefs 86 7 epidemiology epidemiology NN cord-009101-376snefs 86 8 , , , cord-009101-376snefs 86 9 and and CC cord-009101-376snefs 86 10 characteristics characteristic NNS cord-009101-376snefs 86 11 of of IN cord-009101-376snefs 86 12 the the DT cord-009101-376snefs 86 13 virus virus NN cord-009101-376snefs 86 14 ; ; : cord-009101-376snefs 86 15 transmission transmission NN cord-009101-376snefs 86 16 risk risk NN cord-009101-376snefs 86 17 ; ; : cord-009101-376snefs 86 18 and and CC cord-009101-376snefs 86 19 effect(s effect(s NNP cord-009101-376snefs 86 20 ) ) -RRB- cord-009101-376snefs 86 21 on on IN cord-009101-376snefs 86 22 the the DT cord-009101-376snefs 86 23 newborn newborn NN cord-009101-376snefs 86 24 are be VBP cord-009101-376snefs 86 25 identified identify VBN cord-009101-376snefs 86 26 . . . cord-009101-376snefs 87 1 Diagnosis diagnosis NN cord-009101-376snefs 87 2 and and CC cord-009101-376snefs 87 3 clinical clinical JJ cord-009101-376snefs 87 4 manifestations manifestation NNS cord-009101-376snefs 87 5 of of IN cord-009101-376snefs 87 6 the the DT cord-009101-376snefs 87 7 infection infection NN cord-009101-376snefs 87 8 , , , cord-009101-376snefs 87 9 along along IN cord-009101-376snefs 87 10 with with IN cord-009101-376snefs 87 11 treatment treatment NN cord-009101-376snefs 87 12 , , , cord-009101-376snefs 87 13 prognosis prognosis NN cord-009101-376snefs 87 14 , , , cord-009101-376snefs 87 15 and and CC cord-009101-376snefs 87 16 prevention prevention NN cord-009101-376snefs 87 17 strategies strategy NNS cord-009101-376snefs 87 18 , , , cord-009101-376snefs 87 19 are be VBP cord-009101-376snefs 87 20 discussed discuss VBN cord-009101-376snefs 87 21 ( ( -LRB- cord-009101-376snefs 87 22 Arvin Arvin NNP cord-009101-376snefs 87 23 8r 8r NNP cord-009101-376snefs 87 24 Maldonado Maldonado NNP cord-009101-376snefs 87 25 , , , cord-009101-376snefs 87 26 1994 1994 CD cord-009101-376snefs 87 27 ; ; : cord-009101-376snefs 87 28 Cherry Cherry NNP cord-009101-376snefs 87 29 , , , cord-009101-376snefs 87 30 1994 1994 CD cord-009101-376snefs 87 31 ; ; : cord-009101-376snefs 87 32 Gershon Gershon NNP cord-009101-376snefs 87 33 , , , cord-009101-376snefs 87 34 1994 1994 CD cord-009101-376snefs 87 35 ; ; : cord-009101-376snefs 87 36 Mueller Mueller NNP cord-009101-376snefs 87 37 8r 8r NNP cord-009101-376snefs 87 38 Pizzo Pizzo NNP cord-009101-376snefs 87 39 , , , cord-009101-376snefs 87 40 1994 1994 CD cord-009101-376snefs 87 41 ; ; : cord-009101-376snefs 87 42 Torok Torok NNP cord-009101-376snefs 87 43 , , , cord-009101-376snefs 87 44 1994 1994 CD cord-009101-376snefs 87 45 ; ; : cord-009101-376snefs 87 46 Whitley Whitley NNP cord-009101-376snefs 87 47 & & CC cord-009101-376snefs 87 48 Arvin Arvin NNP cord-009101-376snefs 87 49 , , , cord-009101-376snefs 87 50 1994 1994 CD cord-009101-376snefs 87 51 ) ) -RRB- cord-009101-376snefs 87 52 . . . cord-009101-376snefs 88 1 Diagnosis diagnosis NN cord-009101-376snefs 88 2 of of IN cord-009101-376snefs 88 3 viral viral JJ cord-009101-376snefs 88 4 infection infection NN cord-009101-376snefs 88 5 in in IN cord-009101-376snefs 88 6 the the DT cord-009101-376snefs 88 7 newborn newborn NN cord-009101-376snefs 88 8 usually usually RB cord-009101-376snefs 88 9 is be VBZ cord-009101-376snefs 88 10 prompted prompt VBN cord-009101-376snefs 88 11 by by IN cord-009101-376snefs 88 12 a a DT cord-009101-376snefs 88 13 strong strong JJ cord-009101-376snefs 88 14 suspicion suspicion NN cord-009101-376snefs 88 15 based base VBN cord-009101-376snefs 88 16 on on IN cord-009101-376snefs 88 17 physical physical JJ cord-009101-376snefs 88 18 characteristics characteristic NNS cord-009101-376snefs 88 19 of of IN cord-009101-376snefs 88 20 the the DT cord-009101-376snefs 88 21 newborn newborn JJ cord-009101-376snefs 88 22 , , , cord-009101-376snefs 88 23 history history NN cord-009101-376snefs 88 24 of of IN cord-009101-376snefs 88 25 exposure exposure NN cord-009101-376snefs 88 26 or or CC cord-009101-376snefs 88 27 maternal maternal JJ cord-009101-376snefs 88 28 illness illness NN cord-009101-376snefs 88 29 , , , cord-009101-376snefs 88 30 or or CC cord-009101-376snefs 88 31 failure failure NN cord-009101-376snefs 88 32 of of IN cord-009101-376snefs 88 33 sepsis sepsis NN cord-009101-376snefs 88 34 testing testing NN cord-009101-376snefs 88 35 to to TO cord-009101-376snefs 88 36 yield yield VB cord-009101-376snefs 88 37 positive positive JJ cord-009101-376snefs 88 38 results result NNS cord-009101-376snefs 88 39 . . . cord-009101-376snefs 89 1 Careful careful JJ cord-009101-376snefs 89 2 review review NN cord-009101-376snefs 89 3 of of IN cord-009101-376snefs 89 4 the the DT cord-009101-376snefs 89 5 maternal maternal JJ cord-009101-376snefs 89 6 history history NN cord-009101-376snefs 89 7 for for IN cord-009101-376snefs 89 8 evidence evidence NN cord-009101-376snefs 89 9 of of IN cord-009101-376snefs 89 10 viral viral JJ cord-009101-376snefs 89 11 illness illness NN cord-009101-376snefs 89 12 and and CC cord-009101-376snefs 89 13 serum serum NN cord-009101-376snefs 89 14 antibody antibody NN cord-009101-376snefs 89 15 determinations determination NNS cord-009101-376snefs 89 16 can can MD cord-009101-376snefs 89 17 assist assist VB cord-009101-376snefs 89 18 in in IN cord-009101-376snefs 89 19 making make VBG cord-009101-376snefs 89 20 the the DT cord-009101-376snefs 89 21 diagnosis diagnosis NN cord-009101-376snefs 89 22 ; ; : cord-009101-376snefs 89 23 however however RB cord-009101-376snefs 89 24 , , , cord-009101-376snefs 89 25 definitive definitive JJ cord-009101-376snefs 89 26 diagnosis diagnosis NN cord-009101-376snefs 89 27 is be VBZ cord-009101-376snefs 89 28 based base VBN cord-009101-376snefs 89 29 on on IN cord-009101-376snefs 89 30 neonatal neonatal JJ cord-009101-376snefs 89 31 studies study NNS cord-009101-376snefs 89 32 ( ( -LRB- cord-009101-376snefs 89 33 Overall Overall NNP cord-009101-376snefs 89 34 , , , cord-009101-376snefs 89 35 1992 1992 CD cord-009101-376snefs 89 36 ; ; : cord-009101-376snefs 89 37 Smith Smith NNP cord-009101-376snefs 89 38 , , , cord-009101-376snefs 89 39 1993 1993 CD cord-009101-376snefs 89 40 ) ) -RRB- cord-009101-376snefs 89 41 . . . cord-009101-376snefs 90 1 Accurate accurate JJ cord-009101-376snefs 90 2 diagnosis diagnosis NN cord-009101-376snefs 90 3 often often RB cord-009101-376snefs 90 4 is be VBZ cord-009101-376snefs 90 5 difficult difficult JJ cord-009101-376snefs 90 6 . . . cord-009101-376snefs 91 1 Because because IN cord-009101-376snefs 91 2 many many JJ cord-009101-376snefs 91 3 infected infect VBN cord-009101-376snefs 91 4 infants infant NNS cord-009101-376snefs 91 5 have have VBP cord-009101-376snefs 91 6 no no DT cord-009101-376snefs 91 7 symptoms symptom NNS cord-009101-376snefs 91 8 or or CC cord-009101-376snefs 91 9 the the DT cord-009101-376snefs 91 10 clinical clinical JJ cord-009101-376snefs 91 11 manifestations manifestation NNS cord-009101-376snefs 91 12 are be VBP cord-009101-376snefs 91 13 nonspecific nonspecific JJ cord-009101-376snefs 91 14 , , , cord-009101-376snefs 91 15 laboratory laboratory NN cord-009101-376snefs 91 16 diagnostic diagnostic JJ cord-009101-376snefs 91 17 tests test NNS cord-009101-376snefs 91 18 must must MD cord-009101-376snefs 91 19 be be VB cord-009101-376snefs 91 20 used use VBN cord-009101-376snefs 91 21 to to TO cord-009101-376snefs 91 22 determine determine VB cord-009101-376snefs 91 23 the the DT cord-009101-376snefs 91 24 virus virus NN cord-009101-376snefs 91 25 responsible responsible JJ cord-009101-376snefs 91 26 for for IN cord-009101-376snefs 91 27 the the DT cord-009101-376snefs 91 28 illness illness NN cord-009101-376snefs 91 29 . . . cord-009101-376snefs 92 1 Laboratory laboratory NN cord-009101-376snefs 92 2 diagnosis diagnosis NN cord-009101-376snefs 92 3 may may MD cord-009101-376snefs 92 4 involve involve VB cord-009101-376snefs 92 5 direct direct JJ cord-009101-376snefs 92 6 isolation isolation NN cord-009101-376snefs 92 7 of of IN cord-009101-376snefs 92 8 the the DT cord-009101-376snefs 92 9 virus virus NN cord-009101-376snefs 92 10 in in IN cord-009101-376snefs 92 11 culture culture NN cord-009101-376snefs 92 12 ; ; : cord-009101-376snefs 92 13 detection detection NN cord-009101-376snefs 92 14 of of IN cord-009101-376snefs 92 15 viral viral JJ cord-009101-376snefs 92 16 antigen antigen NN cord-009101-376snefs 92 17 or or CC cord-009101-376snefs 92 18 antibodies antibody NNS cord-009101-376snefs 92 19 by by IN cord-009101-376snefs 92 20 immunologic immunologic JJ cord-009101-376snefs 92 21 , , , cord-009101-376snefs 92 22 genetic genetic JJ cord-009101-376snefs 92 23 , , , cord-009101-376snefs 92 24 or or CC cord-009101-376snefs 92 25 electron electron NN cord-009101-376snefs 92 26 microscopic microscopic JJ cord-009101-376snefs 92 27 study study NN cord-009101-376snefs 92 28 ; ; , cord-009101-376snefs 92 29 or or CC cord-009101-376snefs 92 30 histopathologic histopathologic JJ cord-009101-376snefs 92 31 methods method NNS cord-009101-376snefs 92 32 ( ( -LRB- cord-009101-376snefs 92 33 Guerina Guerina NNP cord-009101-376snefs 92 34 & & CC cord-009101-376snefs 92 35 Goldmann Goldmann NNP cord-009101-376snefs 92 36 , , , cord-009101-376snefs 92 37 1993 1993 CD cord-009101-376snefs 92 38 ; ; : cord-009101-376snefs 92 39 Overall Overall NNP cord-009101-376snefs 92 40 , , , cord-009101-376snefs 92 41 1992 1992 CD cord-009101-376snefs 92 42 ; ; : cord-009101-376snefs 92 43 Smith Smith NNP cord-009101-376snefs 92 44 , , , cord-009101-376snefs 92 45 1993 1993 CD cord-009101-376snefs 92 46 ) ) -RRB- cord-009101-376snefs 92 47 . . . cord-009101-376snefs 93 1 The the DT cord-009101-376snefs 93 2 best good JJS cord-009101-376snefs 93 3 method method NN cord-009101-376snefs 93 4 of of IN cord-009101-376snefs 93 5 diagnosis diagnosis NN cord-009101-376snefs 93 6 varies vary VBZ cord-009101-376snefs 93 7 , , , cord-009101-376snefs 93 8 depending depend VBG cord-009101-376snefs 93 9 upon upon IN cord-009101-376snefs 93 10 the the DT cord-009101-376snefs 93 11 specific specific JJ cord-009101-376snefs 93 12 characteristics characteristic NNS cord-009101-376snefs 93 13 of of IN cord-009101-376snefs 93 14 the the DT cord-009101-376snefs 93 15 virus virus NN cord-009101-376snefs 93 16 . . . cord-009101-376snefs 94 1 Recovery recovery NN cord-009101-376snefs 94 2 of of IN cord-009101-376snefs 94 3 virus virus NN cord-009101-376snefs 94 4 from from IN cord-009101-376snefs 94 5 clinical clinical JJ cord-009101-376snefs 94 6 specimens specimen NNS cord-009101-376snefs 94 7 usually usually RB cord-009101-376snefs 94 8 is be VBZ cord-009101-376snefs 94 9 more more RBR cord-009101-376snefs 94 10 difficult difficult JJ cord-009101-376snefs 94 11 than than IN cord-009101-376snefs 94 12 recovery recovery NN cord-009101-376snefs 94 13 of of IN cord-009101-376snefs 94 14 other other JJ cord-009101-376snefs 94 15 microorganisms microorganism NNS cord-009101-376snefs 94 16 ( ( -LRB- cord-009101-376snefs 94 17 Strodtbeck Strodtbeck NNP cord-009101-376snefs 94 18 , , , cord-009101-376snefs 94 19 1986 1986 CD cord-009101-376snefs 94 20 ) ) -RRB- cord-009101-376snefs 94 21 . . . cord-009101-376snefs 95 1 A a DT cord-009101-376snefs 95 2 negative negative JJ cord-009101-376snefs 95 3 result result NN cord-009101-376snefs 95 4 may may MD cord-009101-376snefs 95 5 mean mean VB cord-009101-376snefs 95 6 an an DT cord-009101-376snefs 95 7 unsuccessful unsuccessful JJ cord-009101-376snefs 95 8 recovery recovery NN cord-009101-376snefs 95 9 of of IN cord-009101-376snefs 95 10 virus virus NN cord-009101-376snefs 95 11 present present JJ cord-009101-376snefs 95 12 . . . cord-009101-376snefs 96 1 Clinical clinical JJ cord-009101-376snefs 96 2 judgment judgment NN cord-009101-376snefs 96 3 is be VBZ cord-009101-376snefs 96 4 important important JJ cord-009101-376snefs 96 5 for for IN cord-009101-376snefs 96 6 determining determine VBG cord-009101-376snefs 96 7 the the DT cord-009101-376snefs 96 8 likelihood likelihood NN cord-009101-376snefs 96 9 for for IN cord-009101-376snefs 96 10 additional additional JJ cord-009101-376snefs 96 11 management management NN cord-009101-376snefs 96 12 and and CC cord-009101-376snefs 96 13 treatment treatment NN cord-009101-376snefs 96 14 of of IN cord-009101-376snefs 96 15 the the DT cord-009101-376snefs 96 16 suspected suspect VBN cord-009101-376snefs 96 17 viral viral JJ cord-009101-376snefs 96 18 illness illness NN cord-009101-376snefs 96 19 . . . cord-009101-376snefs 97 1 The the DT cord-009101-376snefs 97 2 most most RBS cord-009101-376snefs 97 3 common common JJ cord-009101-376snefs 97 4 management management NN cord-009101-376snefs 97 5 strategy strategy NN cord-009101-376snefs 97 6 for for IN cord-009101-376snefs 97 7 newborn newborn JJ cord-009101-376snefs 97 8 viral viral JJ cord-009101-376snefs 97 9 infection infection NN cord-009101-376snefs 97 10 is be VBZ cord-009101-376snefs 97 11 supportive supportive JJ cord-009101-376snefs 97 12 care care NN cord-009101-376snefs 97 13 . . . cord-009101-376snefs 98 1 The the DT cord-009101-376snefs 98 2 availability availability NN cord-009101-376snefs 98 3 of of IN cord-009101-376snefs 98 4 specific specific JJ cord-009101-376snefs 98 5 chemotherapies chemotherapy NNS cord-009101-376snefs 98 6 such such JJ cord-009101-376snefs 98 7 as as IN cord-009101-376snefs 98 8 antiviral antiviral JJ cord-009101-376snefs 98 9 drugs drug NNS cord-009101-376snefs 98 10 is be VBZ cord-009101-376snefs 98 11 limited limited JJ cord-009101-376snefs 98 12 . . . cord-009101-376snefs 99 1 Promising promise VBG cord-009101-376snefs 99 2 new new JJ cord-009101-376snefs 99 3 therapies therapy NNS cord-009101-376snefs 99 4 are be VBP cord-009101-376snefs 99 5 being be VBG cord-009101-376snefs 99 6 developed develop VBN cord-009101-376snefs 99 7 , , , cord-009101-376snefs 99 8 and and CC cord-009101-376snefs 99 9 several several JJ cord-009101-376snefs 99 10 are be VBP cord-009101-376snefs 99 11 undergoing undergo VBG cord-009101-376snefs 99 12 evaluation evaluation NN cord-009101-376snefs 99 13 in in IN cord-009101-376snefs 99 14 clinical clinical JJ cord-009101-376snefs 99 15 trials trial NNS cord-009101-376snefs 99 16 with with IN cord-009101-376snefs 99 17 select select JJ cord-009101-376snefs 99 18 populations population NNS cord-009101-376snefs 99 19 ( ( -LRB- cord-009101-376snefs 99 20 Filippell Filippell NNP cord-009101-376snefs 99 21 & & CC cord-009101-376snefs 99 22 Rearick Rearick NNP cord-009101-376snefs 99 23 , , , cord-009101-376snefs 99 24 1993 1993 CD cord-009101-376snefs 99 25 ; ; : cord-009101-376snefs 99 26 Kinney Kinney NNP cord-009101-376snefs 99 27 & & CC cord-009101-376snefs 99 28 Eiden Eiden NNP cord-009101-376snefs 99 29 , , , cord-009101-376snefs 99 30 1994 1994 CD cord-009101-376snefs 99 31 ; ; . cord-009101-376snefs 100 1 Overall overall RB cord-009101-376snefs 100 2 , , , cord-009101-376snefs 100 3 1992 1992 CD cord-009101-376snefs 100 4 ; ; : cord-009101-376snefs 100 5 Stagno Stagno NNP cord-009101-376snefs 100 6 , , , cord-009101-376snefs 100 7 1994 1994 CD cord-009101-376snefs 100 8 ) ) -RRB- cord-009101-376snefs 100 9 . . . cord-009101-376snefs 101 1 Such such JJ cord-009101-376snefs 101 2 therapies therapy NNS cord-009101-376snefs 101 3 include include VBP cord-009101-376snefs 101 4 ganciclovir ganciclovir NNS cord-009101-376snefs 101 5 for for IN cord-009101-376snefs 101 6 CMV CMV NNP cord-009101-376snefs 101 7 disease disease NN cord-009101-376snefs 101 8 , , , cord-009101-376snefs 101 9 hyperimmune hyperimmune NNP cord-009101-376snefs 101 10 intravenous intravenous JJ cord-009101-376snefs 101 11 globulins globulin NNS cord-009101-376snefs 101 12 for for IN cord-009101-376snefs 101 13 CMV CMV NNP cord-009101-376snefs 101 14 and and CC cord-009101-376snefs 101 15 respiratory respiratory JJ cord-009101-376snefs 101 16 syncytial syncytial JJ cord-009101-376snefs 101 17 virus virus NN cord-009101-376snefs 101 18 ( ( -LRB- cord-009101-376snefs 101 19 RSV RSV NNP cord-009101-376snefs 101 20 ) ) -RRB- cord-009101-376snefs 101 21 infections infection NNS cord-009101-376snefs 101 22 , , , cord-009101-376snefs 101 23 and and CC cord-009101-376snefs 101 24 new new JJ cord-009101-376snefs 101 25 vaccinations vaccination NNS cord-009101-376snefs 101 26 for for IN cord-009101-376snefs 101 27 rotavirus rotavirus NN cord-009101-376snefs 101 28 . . . cord-009101-376snefs 102 1 Most Most JJS cord-009101-376snefs 102 2 of of IN cord-009101-376snefs 102 3 these these DT cord-009101-376snefs 102 4 therapies therapy NNS cord-009101-376snefs 102 5 , , , cord-009101-376snefs 102 6 if if IN cord-009101-376snefs 102 7 approved approve VBN cord-009101-376snefs 102 8 for for IN cord-009101-376snefs 102 9 use use NN cord-009101-376snefs 102 10 in in IN cord-009101-376snefs 102 11 newborns newborn NNS cord-009101-376snefs 102 12 , , , cord-009101-376snefs 102 13 will will MD cord-009101-376snefs 102 14 most most RBS cord-009101-376snefs 102 15 likely likely RB cord-009101-376snefs 102 16 lessen lessen VB cord-009101-376snefs 102 17 the the DT cord-009101-376snefs 102 18 severity severity NN cord-009101-376snefs 102 19 of of IN cord-009101-376snefs 102 20 the the DT cord-009101-376snefs 102 21 disease disease NN cord-009101-376snefs 102 22 and and CC cord-009101-376snefs 102 23 subsequent subsequent JJ cord-009101-376snefs 102 24 sequelae sequela NNS cord-009101-376snefs 102 25 , , , cord-009101-376snefs 102 26 rather rather RB cord-009101-376snefs 102 27 than than IN cord-009101-376snefs 102 28 cure cure VB cord-009101-376snefs 102 29 the the DT cord-009101-376snefs 102 30 infection infection NN cord-009101-376snefs 102 31 . . . cord-009101-376snefs 103 1 Other other JJ cord-009101-376snefs 103 2 strategies strategy NNS cord-009101-376snefs 103 3 include include VBP cord-009101-376snefs 103 4 improvements improvement NNS cord-009101-376snefs 103 5 in in IN cord-009101-376snefs 103 6 nutrition nutrition NN cord-009101-376snefs 103 7 for for IN cord-009101-376snefs 103 8 the the DT cord-009101-376snefs 103 9 most most RBS cord-009101-376snefs 103 10 susceptible susceptible JJ cord-009101-376snefs 103 11 newborns newborn NNS cord-009101-376snefs 103 12 , , , cord-009101-376snefs 103 13 interferon interferon NNP cord-009101-376snefs 103 14 administration administration NN cord-009101-376snefs 103 15 to to TO cord-009101-376snefs 103 16 enhance enhance VB cord-009101-376snefs 103 17 viral viral JJ cord-009101-376snefs 103 18 - - HYPH cord-009101-376snefs 103 19 specific specific JJ cord-009101-376snefs 103 20 immune immune JJ cord-009101-376snefs 103 21 defenses defense NNS cord-009101-376snefs 103 22 , , , cord-009101-376snefs 103 23 and and CC cord-009101-376snefs 103 24 lymphokine lymphokine NN cord-009101-376snefs 103 25 enhancement enhancement NN cord-009101-376snefs 103 26 of of IN cord-009101-376snefs 103 27 the the DT cord-009101-376snefs 103 28 neonatal neonatal JJ cord-009101-376snefs 103 29 immune immune JJ cord-009101-376snefs 103 30 system system NN cord-009101-376snefs 103 31 . . . cord-009101-376snefs 104 1 The the DT cord-009101-376snefs 104 2 first first JJ cord-009101-376snefs 104 3 goal goal NN cord-009101-376snefs 104 4 and and CC cord-009101-376snefs 104 5 ultimate ultimate JJ cord-009101-376snefs 104 6 management management NN cord-009101-376snefs 104 7 of of IN cord-009101-376snefs 104 8 neonatal neonatal JJ cord-009101-376snefs 104 9 viral viral JJ cord-009101-376snefs 104 10 disease disease NN cord-009101-376snefs 104 11 is be VBZ cord-009101-376snefs 104 12 prevention prevention NN cord-009101-376snefs 104 13 of of IN cord-009101-376snefs 104 14 the the DT cord-009101-376snefs 104 15 infection infection NN cord-009101-376snefs 104 16 . . . cord-009101-376snefs 105 1 Diligent diligent JJ cord-009101-376snefs 105 2 hand hand NN cord-009101-376snefs 105 3 washing washing NN cord-009101-376snefs 105 4 ; ; , cord-009101-376snefs 105 5 improved improved JJ cord-009101-376snefs 105 6 screening screening NN cord-009101-376snefs 105 7 of of IN cord-009101-376snefs 105 8 visitors visitor NNS cord-009101-376snefs 105 9 and and CC cord-009101-376snefs 105 10 health health NN cord-009101-376snefs 105 11 care care NN cord-009101-376snefs 105 12 providers provider NNS cord-009101-376snefs 105 13 who who WP cord-009101-376snefs 105 14 come come VBP cord-009101-376snefs 105 15 into into IN cord-009101-376snefs 105 16 contact contact NN cord-009101-376snefs 105 17 with with IN cord-009101-376snefs 105 18 susceptible susceptible JJ cord-009101-376snefs 105 19 newborns newborn NNS cord-009101-376snefs 106 1 ; ; : cord-009101-376snefs 106 2 increased increase VBN cord-009101-376snefs 106 3 efforts effort NNS cord-009101-376snefs 106 4 to to TO cord-009101-376snefs 106 5 immunize immunize VB cord-009101-376snefs 106 6 susceptible susceptible JJ cord-009101-376snefs 106 7 populations population NNS cord-009101-376snefs 106 8 , , , cord-009101-376snefs 106 9 such such JJ cord-009101-376snefs 106 10 as as IN cord-009101-376snefs 106 11 childbearing childbeare VBG cord-009101-376snefs 106 12 women woman NNS cord-009101-376snefs 106 13 and and CC cord-009101-376snefs 106 14 children child NNS cord-009101-376snefs 106 15 , , , cord-009101-376snefs 106 16 to to IN cord-009101-376snefs 106 17 known know VBN cord-009101-376snefs 106 18 viral viral JJ cord-009101-376snefs 106 19 pathogens pathogen NNS cord-009101-376snefs 106 20 , , , cord-009101-376snefs 106 21 such such JJ cord-009101-376snefs 106 22 as as IN cord-009101-376snefs 106 23 rubella rubella NN cord-009101-376snefs 106 24 and and CC cord-009101-376snefs 106 25 measles measle NNS cord-009101-376snefs 106 26 ; ; : cord-009101-376snefs 106 27 and and CC cord-009101-376snefs 106 28 immunization immunization NN cord-009101-376snefs 106 29 of of IN cord-009101-376snefs 106 30 health health NN cord-009101-376snefs 106 31 care care NN cord-009101-376snefs 106 32 providers provider NNS cord-009101-376snefs 106 33 who who WP cord-009101-376snefs 106 34 work work VBP cord-009101-376snefs 106 35 with with IN cord-009101-376snefs 106 36 immunocompromised immunocompromised JJ cord-009101-376snefs 106 37 patients patient NNS cord-009101-376snefs 106 38 are be VBP cord-009101-376snefs 106 39 strategies strategy NNS cord-009101-376snefs 106 40 that that WDT cord-009101-376snefs 106 41 can can MD cord-009101-376snefs 106 42 be be VB cord-009101-376snefs 106 43 used use VBN cord-009101-376snefs 106 44 to to TO cord-009101-376snefs 106 45 achieve achieve VB cord-009101-376snefs 106 46 this this DT cord-009101-376snefs 106 47 goal goal NN cord-009101-376snefs 106 48 . . . cord-009101-376snefs 107 1 The the DT cord-009101-376snefs 107 2 American American NNP cord-009101-376snefs 107 3 Academy Academy NNP cord-009101-376snefs 107 4 of of IN cord-009101-376snefs 107 5 Pediatrics Pediatrics NNP cord-009101-376snefs 107 6 ( ( -LRB- cord-009101-376snefs 107 7 1994 1994 CD cord-009101-376snefs 107 8 ) ) -RRB- cord-009101-376snefs 107 9 recommendation recommendation NN cord-009101-376snefs 107 10 that that IN cord-009101-376snefs 107 11 all all DT cord-009101-376snefs 107 12 neonatal neonatal JJ cord-009101-376snefs 107 13 intensive intensive JJ cord-009101-376snefs 107 14 care care NN cord-009101-376snefs 107 15 unit unit NN cord-009101-376snefs 107 16 ( ( -LRB- cord-009101-376snefs 107 17 NICU NICU NNP cord-009101-376snefs 107 18 ) ) -RRB- cord-009101-376snefs 107 19 staff staff NN cord-009101-376snefs 107 20 members member NNS cord-009101-376snefs 107 21 receive receive VBP cord-009101-376snefs 107 22 annual annual JJ cord-009101-376snefs 107 23 influenza influenza NN cord-009101-376snefs 107 24 immunizations immunization NNS cord-009101-376snefs 107 25 to to TO cord-009101-376snefs 107 26 prevent prevent VB cord-009101-376snefs 107 27 the the DT cord-009101-376snefs 107 28 spread spread NN cord-009101-376snefs 107 29 of of IN cord-009101-376snefs 107 30 infection infection NN cord-009101-376snefs 107 31 to to IN cord-009101-376snefs 107 32 infants infant NNS cord-009101-376snefs 107 33 with with IN cord-009101-376snefs 107 34 chronic chronic JJ cord-009101-376snefs 107 35 lung lung NN cord-009101-376snefs 107 36 disease disease NN cord-009101-376snefs 107 37 is be VBZ cord-009101-376snefs 107 38 routinely routinely RB cord-009101-376snefs 107 39 ignored ignore VBN cord-009101-376snefs 107 40 by by IN cord-009101-376snefs 107 41 most most JJS cord-009101-376snefs 107 42 units unit NNS cord-009101-376snefs 107 43 across across IN cord-009101-376snefs 107 44 the the DT cord-009101-376snefs 107 45 country country NN cord-009101-376snefs 107 46 ( ( -LRB- cord-009101-376snefs 107 47 Eisenfeld Eisenfeld NNP cord-009101-376snefs 107 48 et et NNP cord-009101-376snefs 107 49 al al NNP cord-009101-376snefs 107 50 . . NNP cord-009101-376snefs 107 51 , , , cord-009101-376snefs 107 52 1994 1994 CD cord-009101-376snefs 107 53 ) ) -RRB- cord-009101-376snefs 107 54 . . . cord-009101-376snefs 108 1 Nursing nursing NN cord-009101-376snefs 108 2 care care NN cord-009101-376snefs 108 3 of of IN cord-009101-376snefs 108 4 the the DT cord-009101-376snefs 108 5 newborn newborn NN cord-009101-376snefs 108 6 with with IN cord-009101-376snefs 108 7 a a DT cord-009101-376snefs 108 8 viral viral JJ cord-009101-376snefs 108 9 illness illness NN cord-009101-376snefs 108 10 is be VBZ cord-009101-376snefs 108 11 determined determine VBN cord-009101-376snefs 108 12 by by IN cord-009101-376snefs 108 13 the the DT cord-009101-376snefs 108 14 specific specific JJ cord-009101-376snefs 108 15 viral viral JJ cord-009101-376snefs 108 16 infection infection NN cord-009101-376snefs 108 17 , , , cord-009101-376snefs 108 18 the the DT cord-009101-376snefs 108 19 severity severity NN cord-009101-376snefs 108 20 of of IN cord-009101-376snefs 108 21 the the DT cord-009101-376snefs 108 22 illness illness NN cord-009101-376snefs 108 23 , , , cord-009101-376snefs 108 24 and and CC cord-009101-376snefs 108 25 the the DT cord-009101-376snefs 108 26 unique unique JJ cord-009101-376snefs 108 27 conditions condition NNS cord-009101-376snefs 108 28 of of IN cord-009101-376snefs 108 29 the the DT cord-009101-376snefs 108 30 newborn newborn NN cord-009101-376snefs 108 31 and and CC cord-009101-376snefs 108 32 his -PRON- PRP$ cord-009101-376snefs 108 33 / / SYM cord-009101-376snefs 108 34 her -PRON- PRP$ cord-009101-376snefs 108 35 family family NN cord-009101-376snefs 108 36 . . . cord-009101-376snefs 109 1 Newborns newborn NNS cord-009101-376snefs 109 2 with with IN cord-009101-376snefs 109 3 a a DT cord-009101-376snefs 109 4 known know VBN cord-009101-376snefs 109 5 viral viral JJ cord-009101-376snefs 109 6 infection infection NN cord-009101-376snefs 109 7 who who WP cord-009101-376snefs 109 8 have have VBP cord-009101-376snefs 109 9 no no DT cord-009101-376snefs 109 10 symptoms symptom NNS cord-009101-376snefs 109 11 require require VB cord-009101-376snefs 109 12 no no DT cord-009101-376snefs 109 13 special special JJ cord-009101-376snefs 109 14 nursing nursing NN cord-009101-376snefs 109 15 care care NN cord-009101-376snefs 109 16 while while IN cord-009101-376snefs 109 17 in in IN cord-009101-376snefs 109 18 the the DT cord-009101-376snefs 109 19 hospital hospital NN cord-009101-376snefs 109 20 . . . cord-009101-376snefs 110 1 Newborns newborn NNS cord-009101-376snefs 110 2 with with IN cord-009101-376snefs 110 3 viruses virus NNS cord-009101-376snefs 110 4 such such JJ cord-009101-376snefs 110 5 as as IN cord-009101-376snefs 110 6 rubella rubella NN cord-009101-376snefs 110 7 and and CC cord-009101-376snefs 110 8 CMV CMV NNP cord-009101-376snefs 110 9 who who WP cord-009101-376snefs 110 10 have have VBP cord-009101-376snefs 110 11 no no DT cord-009101-376snefs 110 12 symptoms symptom NNS cord-009101-376snefs 110 13 should should MD cord-009101-376snefs 110 14 be be VB cord-009101-376snefs 110 15 followed follow VBN cord-009101-376snefs 110 16 up up RP cord-009101-376snefs 110 17 closely closely RB cord-009101-376snefs 110 18 for for IN cord-009101-376snefs 110 19 the the DT cord-009101-376snefs 110 20 development development NN cord-009101-376snefs 110 21 of of IN cord-009101-376snefs 110 22 late late JJ cord-009101-376snefs 110 23 onset onset NN cord-009101-376snefs 110 24 se- se- VBG cord-009101-376snefs 110 25 Cherry cherry NN cord-009101-376snefs 110 26 , , , cord-009101-376snefs 110 27 1994 1994 CD cord-009101-376snefs 111 1 ; ; : cord-009101-376snefs 111 2 Cooper Cooper NNP cord-009101-376snefs 111 3 , , , cord-009101-376snefs 111 4 Preblud Preblud NNP cord-009101-376snefs 111 5 , , , cord-009101-376snefs 111 6 8r 8r CD cord-009101-376snefs 111 7 Alford Alford NNP cord-009101-376snefs 111 8 , , , cord-009101-376snefs 111 9 Rearick Rearick NNP cord-009101-376snefs 111 10 Gershon Gershon NNP cord-009101-376snefs 111 11 , , , cord-009101-376snefs 111 12 1994 1994 CD cord-009101-376snefs 111 13 ; ; : cord-009101-376snefs 111 14 Giacoia Giacoia NNP cord-009101-376snefs 111 15 , , , cord-009101-376snefs 111 16 1994 1994 CD cord-009101-376snefs 111 17 ; ; : cord-009101-376snefs 111 18 Kinney Kinney NNP cord-009101-376snefs 111 19 bz bz NNP cord-009101-376snefs 111 20 Eiden Eiden NNP cord-009101-376snefs 111 21 , , , cord-009101-376snefs 111 22 AZT AZT NNP cord-009101-376snefs 111 23 : : : cord-009101-376snefs 111 24 zidovudine zidovudine NN cord-009101-376snefs 111 25 ; ; : cord-009101-376snefs 111 26 CNS CNS NNP cord-009101-376snefs 111 27 : : : cord-009101-376snefs 111 28 central central JJ cord-009101-376snefs 111 29 nervous nervous JJ cord-009101-376snefs 111 30 system system NN cord-009101-376snefs 111 31 ; ; : cord-009101-376snefs 111 32 DDC DDC NNP cord-009101-376snefs 111 33 : : : cord-009101-376snefs 111 34 dideoxycytidine dideoxycytidine NN cord-009101-376snefs 111 35 ; ; : cord-009101-376snefs 111 36 DDI DDI NNP cord-009101-376snefs 111 37 : : : cord-009101-376snefs 111 38 dideoxyinosine dideoxyinosine NNP cord-009101-376snefs 111 39 ; ; : cord-009101-376snefs 111 40 DIC DIC NNP cord-009101-376snefs 111 41 : : : cord-009101-376snefs 111 42 disseminated disseminate VBN cord-009101-376snefs 111 43 intravascular intravascular JJ cord-009101-376snefs 111 44 coagulation coagulation NN cord-009101-376snefs 111 45 ; ; : cord-009101-376snefs 111 46 NEC nec NN cord-009101-376snefs 111 47 : : : cord-009101-376snefs 111 48 necrotizing necrotize VBG cord-009101-376snefs 111 49 enterocolitis enterocolitis NN cord-009101-376snefs 111 50 ; ; : cord-009101-376snefs 111 51 Mueller Mueller NNP cord-009101-376snefs 111 52 L(r L(r NNP cord-009101-376snefs 111 53 Pizzo Pizzo NNP cord-009101-376snefs 111 54 , , , cord-009101-376snefs 111 55 1994 1994 CD cord-009101-376snefs 111 56 ; ; : cord-009101-376snefs 111 57 Overall Overall NNP cord-009101-376snefs 111 58 , , , cord-009101-376snefs 111 59 1992 1992 CD cord-009101-376snefs 111 60 ; ; : cord-009101-376snefs 111 61 Smith Smith NNP cord-009101-376snefs 111 62 , , , cord-009101-376snefs 111 63 1993 1993 CD cord-009101-376snefs 111 64 ; ; : cord-009101-376snefs 111 65 Stagno Stagno NNP cord-009101-376snefs 111 66 , , , cord-009101-376snefs 111 67 1994 1994 CD cord-009101-376snefs 111 68 ; ; : cord-009101-376snefs 111 69 Torok Torok NNP cord-009101-376snefs 111 70 , , , cord-009101-376snefs 111 71 1994 1994 CD cord-009101-376snefs 111 72 ; ; : cord-009101-376snefs 111 73 Whitley Whitley NNP cord-009101-376snefs 111 74 8r 8r NNP cord-009101-376snefs 111 75 Arvin Arvin NNP cord-009101-376snefs 111 76 , , , cord-009101-376snefs 111 77 NICU NICU NNP cord-009101-376snefs 111 78 : : : cord-009101-376snefs 111 79 neonatal neonatal JJ cord-009101-376snefs 111 80 intensive intensive JJ cord-009101-376snefs 111 81 care care NN cord-009101-376snefs 111 82 unit unit NN cord-009101-376snefs 111 83 . . . cord-009101-376snefs 112 1 egies egie NNS cord-009101-376snefs 112 2 are be VBP cord-009101-376snefs 112 3 important important JJ cord-009101-376snefs 112 4 for for IN cord-009101-376snefs 112 5 protecting protect VBG cord-009101-376snefs 112 6 the the DT cord-009101-376snefs 112 7 ill ill JJ cord-009101-376snefs 112 8 newborn newborn JJ cord-009101-376snefs 112 9 from from IN cord-009101-376snefs 112 10 other other JJ cord-009101-376snefs 112 11 infections infection NNS cord-009101-376snefs 112 12 and and CC cord-009101-376snefs 112 13 preventing prevent VBG cord-009101-376snefs 112 14 nosocomial nosocomial JJ cord-009101-376snefs 112 15 spread spread NN cord-009101-376snefs 112 16 of of IN cord-009101-376snefs 112 17 the the DT cord-009101-376snefs 112 18 usually usually RB cord-009101-376snefs 112 19 is be VBZ cord-009101-376snefs 112 20 prompted prompt VBN cord-009101-376snefs 112 21 by by IN cord-009101-376snefs 112 22 a a DT cord-009101-376snefs 112 23 strong strong JJ cord-009101-376snefs 112 24 suspicion suspicion NN cord-009101-376snefs 112 25 based base VBN cord-009101-376snefs 112 26 on on IN cord-009101-376snefs 112 27 physical physical JJ cord-009101-376snefs 112 28 characteristics characteristic NNS cord-009101-376snefs 112 29 of of IN cord-009101-376snefs 112 30 the the DT cord-009101-376snefs 112 31 newborn newborn JJ cord-009101-376snefs 112 32 , , , cord-009101-376snefs 112 33 history history NN cord-009101-376snefs 112 34 of of IN cord-009101-376snefs 112 35 exposure exposure NN cord-009101-376snefs 112 36 or or CC cord-009101-376snefs 112 37 maternal maternal JJ cord-009101-376snefs 112 38 illness illness NN cord-009101-376snefs 112 39 , , , cord-009101-376snefs 112 40 or or CC cord-009101-376snefs 112 41 failure failure NN cord-009101-376snefs 112 42 of of IN cord-009101-376snefs 112 43 sepsis sepsis NN cord-009101-376snefs 112 44 testing testing NN cord-009101-376snefs 112 45 to to TO cord-009101-376snefs 112 46 yield yield VB cord-009101-376snefs 112 47 positive positive JJ cord-009101-376snefs 112 48 results result NNS cord-009101-376snefs 112 49 . . . cord-009101-376snefs 113 1 quelae quelae NNP cord-009101-376snefs 113 2 ( ( -LRB- cord-009101-376snefs 113 3 Cooper Cooper NNP cord-009101-376snefs 113 4 , , , cord-009101-376snefs 113 5 Preblud Preblud NNP cord-009101-376snefs 113 6 , , , cord-009101-376snefs 113 7 tk tk NNP cord-009101-376snefs 113 8 Alford Alford NNP cord-009101-376snefs 113 9 , , , cord-009101-376snefs 113 10 1994 1994 CD cord-009101-376snefs 113 11 ; ; : cord-009101-376snefs 113 12 Overall Overall NNP cord-009101-376snefs 113 13 , , , cord-009101-376snefs 113 14 1992 1992 CD cord-009101-376snefs 113 15 ) ) -RRB- cord-009101-376snefs 113 16 . . . cord-009101-376snefs 114 1 Family family NN cord-009101-376snefs 114 2 members member NNS cord-009101-376snefs 114 3 should should MD cord-009101-376snefs 114 4 be be VB cord-009101-376snefs 114 5 provided provide VBN cord-009101-376snefs 114 6 with with IN cord-009101-376snefs 114 7 available available JJ cord-009101-376snefs 114 8 educational educational JJ cord-009101-376snefs 114 9 materials material NNS cord-009101-376snefs 114 10 . . . cord-009101-376snefs 115 1 Brochures brochure NNS cord-009101-376snefs 115 2 , , , cord-009101-376snefs 115 3 such such JJ cord-009101-376snefs 115 4 as as IN cord-009101-376snefs 115 5 those those DT cord-009101-376snefs 115 6 on on IN cord-009101-376snefs 115 7 CMVfrom CMVfrom NNP cord-009101-376snefs 115 8 the the DT cord-009101-376snefs 115 9 Children Children NNPS cord-009101-376snefs 115 10 's 's POS cord-009101-376snefs 115 11 Biomedical Biomedical NNP cord-009101-376snefs 115 12 Research Research NNP cord-009101-376snefs 115 13 Institute Institute NNP cord-009101-376snefs 115 14 in in IN cord-009101-376snefs 115 15 St. St. NNP cord-009101-376snefs 115 16 Paul Paul NNP cord-009101-376snefs 115 17 , , , cord-009101-376snefs 115 18 Minnesota Minnesota NNP cord-009101-376snefs 115 19 , , , cord-009101-376snefs 115 20 can can MD cord-009101-376snefs 115 21 be be VB cord-009101-376snefs 115 22 helpful helpful JJ cord-009101-376snefs 115 23 for for IN cord-009101-376snefs 115 24 some some DT cord-009101-376snefs 115 25 families family NNS cord-009101-376snefs 115 26 ( ( -LRB- cord-009101-376snefs 115 27 Children Children NNP cord-009101-376snefs 115 28 's 's POS cord-009101-376snefs 115 29 Hospital Hospital NNP cord-009101-376snefs 115 30 , , , cord-009101-376snefs 115 31 1989 1989 CD cord-009101-376snefs 115 32 ) ) -RRB- cord-009101-376snefs 115 33 . . . cord-009101-376snefs 116 1 The the DT cord-009101-376snefs 116 2 first first JJ cord-009101-376snefs 116 3 action action NN cord-009101-376snefs 116 4 of of IN cord-009101-376snefs 116 5 nursing nursing NN cord-009101-376snefs 116 6 care care NN cord-009101-376snefs 116 7 of of IN cord-009101-376snefs 116 8 the the DT cord-009101-376snefs 116 9 newborn newborn NN cord-009101-376snefs 116 10 with with IN cord-009101-376snefs 116 11 symptoms symptom NNS cord-009101-376snefs 116 12 often often RB cord-009101-376snefs 116 13 is be VBZ cord-009101-376snefs 116 14 to to TO cord-009101-376snefs 116 15 raise raise VB cord-009101-376snefs 116 16 the the DT cord-009101-376snefs 116 17 index index NN cord-009101-376snefs 116 18 of of IN cord-009101-376snefs 116 19 suspicion suspicion NN cord-009101-376snefs 116 20 for for IN cord-009101-376snefs 116 21 viral viral JJ cord-009101-376snefs 116 22 disease disease NN cord-009101-376snefs 116 23 . . . cord-009101-376snefs 117 1 The the DT cord-009101-376snefs 117 2 presence presence NN cord-009101-376snefs 117 3 of of IN cord-009101-376snefs 117 4 physical physical JJ cord-009101-376snefs 117 5 findings finding NNS cord-009101-376snefs 117 6 , , , cord-009101-376snefs 117 7 such such JJ cord-009101-376snefs 117 8 as as IN cord-009101-376snefs 117 9 characteristic characteristic JJ cord-009101-376snefs 117 10 rashes rash NNS cord-009101-376snefs 117 11 or or CC cord-009101-376snefs 117 12 vesicles vesicle NNS cord-009101-376snefs 117 13 , , , cord-009101-376snefs 117 14 microcephaly microcephaly NNS cord-009101-376snefs 117 15 , , , cord-009101-376snefs 117 16 intrauterine intrauterine JJ cord-009101-376snefs 117 17 growth growth NN cord-009101-376snefs 117 18 retardation retardation NN cord-009101-376snefs 117 19 or or CC cord-009101-376snefs 117 20 small small JJ cord-009101-376snefs 117 21 size size NN cord-009101-376snefs 117 22 for for IN cord-009101-376snefs 117 23 gestational gestational JJ cord-009101-376snefs 117 24 age age NN cord-009101-376snefs 117 25 , , , cord-009101-376snefs 117 26 should should MD cord-009101-376snefs 117 27 alert alert VB cord-009101-376snefs 117 28 the the DT cord-009101-376snefs 117 29 nurse nurse NN cord-009101-376snefs 117 30 to to IN cord-009101-376snefs 117 31 the the DT cord-009101-376snefs 117 32 possibility possibility NN cord-009101-376snefs 117 33 of of IN cord-009101-376snefs 117 34 congenital congenital JJ cord-009101-376snefs 117 35 infection infection NN cord-009101-376snefs 117 36 . . . cord-009101-376snefs 118 1 Obtaining obtain VBG cord-009101-376snefs 118 2 a a DT cord-009101-376snefs 118 3 detailed detailed JJ cord-009101-376snefs 118 4 , , , cord-009101-376snefs 118 5 accurate accurate JJ cord-009101-376snefs 118 6 maternal maternal JJ cord-009101-376snefs 118 7 history history NN cord-009101-376snefs 118 8 , , , cord-009101-376snefs 118 9 including include VBG cord-009101-376snefs 118 10 immunizations immunization NNS cord-009101-376snefs 118 11 received receive VBN cord-009101-376snefs 118 12 , , , cord-009101-376snefs 118 13 signs sign NNS cord-009101-376snefs 118 14 / / SYM cord-009101-376snefs 118 15 symptoms symptom NNS cord-009101-376snefs 118 16 of of IN cord-009101-376snefs 118 17 possible possible JJ cord-009101-376snefs 118 18 viral viral JJ cord-009101-376snefs 118 19 illness illness NN cord-009101-376snefs 118 20 during during IN cord-009101-376snefs 118 21 the the DT cord-009101-376snefs 118 22 pregnancy pregnancy NN cord-009101-376snefs 118 23 , , , cord-009101-376snefs 118 24 and and CC cord-009101-376snefs 118 25 exposure exposure NN cord-009101-376snefs 118 26 to to IN cord-009101-376snefs 118 27 possible possible JJ cord-009101-376snefs 118 28 sources source NNS cord-009101-376snefs 118 29 of of IN cord-009101-376snefs 118 30 viral viral JJ cord-009101-376snefs 118 31 infection infection NN cord-009101-376snefs 118 32 , , , cord-009101-376snefs 118 33 is be VBZ cord-009101-376snefs 118 34 important important JJ cord-009101-376snefs 118 35 . . . cord-009101-376snefs 119 1 Collecting collect VBG cord-009101-376snefs 119 2 correct correct JJ cord-009101-376snefs 119 3 specimens specimen NNS cord-009101-376snefs 119 4 for for IN cord-009101-376snefs 119 5 diagnostic diagnostic JJ cord-009101-376snefs 119 6 tests test NNS cord-009101-376snefs 119 7 and and CC cord-009101-376snefs 119 8 cultures culture NNS cord-009101-376snefs 119 9 is be VBZ cord-009101-376snefs 119 10 as as RB cord-009101-376snefs 119 11 important important JJ cord-009101-376snefs 119 12 as as IN cord-009101-376snefs 119 13 prompt prompt JJ cord-009101-376snefs 119 14 processing processing NN cord-009101-376snefs 119 15 by by IN cord-009101-376snefs 119 16 the the DT cord-009101-376snefs 119 17 clinical clinical JJ cord-009101-376snefs 119 18 laboratory laboratory NN cord-009101-376snefs 119 19 ( ( -LRB- cord-009101-376snefs 119 20 Strodtbeck Strodtbeck NNP cord-009101-376snefs 119 21 , , , cord-009101-376snefs 119 22 1986 1986 CD cord-009101-376snefs 119 23 ) ) -RRB- cord-009101-376snefs 119 24 . . . cord-009101-376snefs 120 1 Nursing nursing NN cord-009101-376snefs 120 2 care care NN cord-009101-376snefs 120 3 of of IN cord-009101-376snefs 120 4 the the DT cord-009101-376snefs 120 5 newborn newborn NN cord-009101-376snefs 120 6 with with IN cord-009101-376snefs 120 7 severe severe JJ cord-009101-376snefs 120 8 viral viral JJ cord-009101-376snefs 120 9 disease disease NN cord-009101-376snefs 120 10 is be VBZ cord-009101-376snefs 120 11 complex complex JJ cord-009101-376snefs 120 12 and and CC cord-009101-376snefs 120 13 varies vary VBZ cord-009101-376snefs 120 14 according accord VBG cord-009101-376snefs 120 15 to to IN cord-009101-376snefs 120 16 the the DT cord-009101-376snefs 120 17 clinical clinical JJ cord-009101-376snefs 120 18 presentation presentation NN cord-009101-376snefs 120 19 of of IN cord-009101-376snefs 120 20 the the DT cord-009101-376snefs 120 21 neonate neonate NN cord-009101-376snefs 120 22 . . . cord-009101-376snefs 121 1 Presentation presentation NN cord-009101-376snefs 121 2 of of IN cord-009101-376snefs 121 3 specific specific JJ cord-009101-376snefs 121 4 management management NN cord-009101-376snefs 121 5 plans plan NNS cord-009101-376snefs 121 6 for for IN cord-009101-376snefs 121 7 each each DT cord-009101-376snefs 121 8 viral viral JJ cord-009101-376snefs 121 9 infection infection NN cord-009101-376snefs 121 10 is be VBZ cord-009101-376snefs 121 11 beyond beyond IN cord-009101-376snefs 121 12 the the DT cord-009101-376snefs 121 13 scope scope NN cord-009101-376snefs 121 14 of of IN cord-009101-376snefs 121 15 this this DT cord-009101-376snefs 121 16 article article NN cord-009101-376snefs 121 17 . . . cord-009101-376snefs 122 1 General general JJ cord-009101-376snefs 122 2 nursing nursing NN cord-009101-376snefs 122 3 care care NN cord-009101-376snefs 122 4 may may MD cord-009101-376snefs 122 5 involve involve VB cord-009101-376snefs 122 6 ventilator ventilator NN cord-009101-376snefs 122 7 therapy therapy NN cord-009101-376snefs 122 8 , , , cord-009101-376snefs 122 9 pharmacologic pharmacologic JJ cord-009101-376snefs 122 10 support support NN cord-009101-376snefs 122 11 of of IN cord-009101-376snefs 122 12 cardiovascular cardiovascular JJ cord-009101-376snefs 122 13 status status NN cord-009101-376snefs 122 14 , , , cord-009101-376snefs 122 15 correction correction NN cord-009101-376snefs 122 16 of of IN cord-009101-376snefs 122 17 acidosis acidosis NN cord-009101-376snefs 122 18 and and CC cord-009101-376snefs 122 19 shock shock NN cord-009101-376snefs 122 20 states state NNS cord-009101-376snefs 122 21 , , , cord-009101-376snefs 122 22 correction correction NN cord-009101-376snefs 122 23 of of IN cord-009101-376snefs 122 24 coagulopathies coagulopathie NNS cord-009101-376snefs 122 25 , , , cord-009101-376snefs 122 26 and and CC cord-009101-376snefs 122 27 treatment treatment NN cord-009101-376snefs 122 28 of of IN cord-009101-376snefs 122 29 severe severe JJ cord-009101-376snefs 122 30 neurologic neurologic JJ cord-009101-376snefs 122 31 disorders disorder NNS cord-009101-376snefs 122 32 , , , cord-009101-376snefs 122 33 such such JJ cord-009101-376snefs 122 34 as as IN cord-009101-376snefs 122 35 meningitis meningitis NN cord-009101-376snefs 122 36 and and CC cord-009101-376snefs 122 37 seizures seizure NNS cord-009101-376snefs 122 38 . . . cord-009101-376snefs 123 1 Skin skin NN cord-009101-376snefs 123 2 care care NN cord-009101-376snefs 123 3 and and CC cord-009101-376snefs 123 4 nutrition nutrition NN cord-009101-376snefs 123 5 are be VBP cord-009101-376snefs 123 6 other other JJ cord-009101-376snefs 123 7 areas area NNS cord-009101-376snefs 123 8 of of IN cord-009101-376snefs 123 9 concern concern NN cord-009101-376snefs 123 10 to to IN cord-009101-376snefs 123 11 nursing nursing NN cord-009101-376snefs 123 12 because because IN cord-009101-376snefs 123 13 many many JJ cord-009101-376snefs 123 14 infants infant NNS cord-009101-376snefs 123 15 may may MD cord-009101-376snefs 123 16 have have VB cord-009101-376snefs 123 17 rashes rash NNS cord-009101-376snefs 123 18 or or CC cord-009101-376snefs 123 19 be be VB cord-009101-376snefs 123 20 at at IN cord-009101-376snefs 123 21 risk risk NN cord-009101-376snefs 123 22 for for IN cord-009101-376snefs 123 23 secondary secondary JJ cord-009101-376snefs 123 24 infections infection NNS cord-009101-376snefs 123 25 . . . cord-009101-376snefs 124 1 Care care NN cord-009101-376snefs 124 2 of of IN cord-009101-376snefs 124 3 the the DT cord-009101-376snefs 124 4 family family NN cord-009101-376snefs 124 5 is be VBZ cord-009101-376snefs 124 6 important important JJ cord-009101-376snefs 124 7 and and CC cord-009101-376snefs 124 8 can can MD cord-009101-376snefs 124 9 be be VB cord-009101-376snefs 124 10 complicated complicate VBN cord-009101-376snefs 124 11 by by IN cord-009101-376snefs 124 12 maternal maternal JJ cord-009101-376snefs 124 13 or or CC cord-009101-376snefs 124 14 paternal paternal JJ cord-009101-376snefs 124 15 feelings feeling NNS cord-009101-376snefs 124 16 of of IN cord-009101-376snefs 124 17 guilt guilt NN cord-009101-376snefs 124 18 regarding regard VBG cord-009101-376snefs 124 19 congenital congenital JJ cord-009101-376snefs 124 20 infection infection NN cord-009101-376snefs 124 21 or or CC cord-009101-376snefs 124 22 infection infection NN cord-009101-376snefs 124 23 acquired acquire VBN cord-009101-376snefs 124 24 at at IN cord-009101-376snefs 124 25 the the DT cord-009101-376snefs 124 26 time time NN cord-009101-376snefs 124 27 of of IN cord-009101-376snefs 124 28 delivery delivery NN cord-009101-376snefs 124 29 . . . cord-009101-376snefs 125 1 The the DT cord-009101-376snefs 125 2 need need NN cord-009101-376snefs 125 3 for for IN cord-009101-376snefs 125 4 special special JJ cord-009101-376snefs 125 5 care care NN cord-009101-376snefs 125 6 such such JJ cord-009101-376snefs 125 7 as as IN cord-009101-376snefs 125 8 isolation isolation NN cord-009101-376snefs 125 9 also also RB cord-009101-376snefs 125 10 can can MD cord-009101-376snefs 125 11 present present VB cord-009101-376snefs 125 12 problems problem NNS cord-009101-376snefs 125 13 and and CC cord-009101-376snefs 125 14 increase increase VB cord-009101-376snefs 125 15 the the DT cord-009101-376snefs 125 16 family family NN cord-009101-376snefs 125 17 's 's POS cord-009101-376snefs 125 18 stress stress NN cord-009101-376snefs 125 19 . . . cord-009101-376snefs 126 1 Meticulous meticulous JJ cord-009101-376snefs 126 2 attention attention NN cord-009101-376snefs 126 3 to to IN cord-009101-376snefs 126 4 hand hand NN cord-009101-376snefs 126 5 washing washing NN cord-009101-376snefs 126 6 , , , cord-009101-376snefs 126 7 aseptic aseptic JJ cord-009101-376snefs 126 8 technique technique NN cord-009101-376snefs 126 9 , , , cord-009101-376snefs 126 10 and and CC cord-009101-376snefs 126 11 the the DT cord-009101-376snefs 126 12 use use NN cord-009101-376snefs 126 13 of of IN cord-009101-376snefs 126 14 personal personal JJ cord-009101-376snefs 126 15 protective protective JJ cord-009101-376snefs 126 16 equipment equipment NN cord-009101-376snefs 126 17 are be VBP cord-009101-376snefs 126 18 additional additional JJ cord-009101-376snefs 126 19 important important JJ cord-009101-376snefs 126 20 aspects aspect NNS cord-009101-376snefs 126 21 of of IN cord-009101-376snefs 126 22 nursing nursing NN cord-009101-376snefs 126 23 care care NN cord-009101-376snefs 126 24 . . . cord-009101-376snefs 127 1 These these DT cord-009101-376snefs 127 2 last last JJ cord-009101-376snefs 127 3 strat- strat- NN cord-009101-376snefs 128 1 Within within IN cord-009101-376snefs 128 2 recent recent JJ cord-009101-376snefs 128 3 years year NNS cord-009101-376snefs 128 4 , , , cord-009101-376snefs 128 5 there there EX cord-009101-376snefs 128 6 has have VBZ cord-009101-376snefs 128 7 been be VBN cord-009101-376snefs 128 8 a a DT cord-009101-376snefs 128 9 developing develop VBG cord-009101-376snefs 128 10 awareness awareness NN cord-009101-376snefs 128 11 on on IN cord-009101-376snefs 128 12 the the DT cord-009101-376snefs 128 13 national national JJ cord-009101-376snefs 128 14 level level NN cord-009101-376snefs 128 15 of of IN cord-009101-376snefs 128 16 the the DT cord-009101-376snefs 128 17 role role NN cord-009101-376snefs 128 18 of of IN cord-009101-376snefs 128 19 viruses virus NNS cord-009101-376snefs 128 20 as as IN cord-009101-376snefs 128 21 nosocomial nosocomial JJ cord-009101-376snefs 128 22 pathogens pathogen NNS cord-009101-376snefs 128 23 ( ( -LRB- cord-009101-376snefs 128 24 Giacoia Giacoia NNP cord-009101-376snefs 128 25 , , , cord-009101-376snefs 128 26 1994 1994 CD cord-009101-376snefs 128 27 ; ; : cord-009101-376snefs 128 28 Guerina Guerina NNP cord-009101-376snefs 128 29 & & CC cord-009101-376snefs 128 30 Goldmann Goldmann NNP cord-009101-376snefs 128 31 , , , cord-009101-376snefs 128 32 1993 1993 CD cord-009101-376snefs 128 33 ; ; : cord-009101-376snefs 128 34 Strodtbeck Strodtbeck NNP cord-009101-376snefs 128 35 , , , cord-009101-376snefs 128 36 1986 1986 CD cord-009101-376snefs 128 37 ) ) -RRB- cord-009101-376snefs 128 38 . . . cord-009101-376snefs 129 1 Although although IN cord-009101-376snefs 129 2 viral viral JJ cord-009101-376snefs 129 3 infections infection NNS cord-009101-376snefs 129 4 are be VBP cord-009101-376snefs 129 5 uncommon uncommon JJ cord-009101-376snefs 129 6 in in IN cord-009101-376snefs 129 7 the the DT cord-009101-376snefs 129 8 newborn newborn JJ cord-009101-376snefs 129 9 nursery nursery NN cord-009101-376snefs 129 10 , , , cord-009101-376snefs 129 11 the the DT cord-009101-376snefs 129 12 potential potential NN cord-009101-376snefs 129 13 for for IN cord-009101-376snefs 129 14 outbreaks outbreak NNS cord-009101-376snefs 129 15 remains remain VBZ cord-009101-376snefs 129 16 a a DT cord-009101-376snefs 129 17 constant constant JJ cord-009101-376snefs 129 18 concern concern NN cord-009101-376snefs 129 19 , , , cord-009101-376snefs 129 20 especially especially RB cord-009101-376snefs 129 21 during during IN cord-009101-376snefs 129 22 peak peak NN cord-009101-376snefs 129 23 seasons season NNS cord-009101-376snefs 129 24 of of IN cord-009101-376snefs 129 25 viral viral JJ cord-009101-376snefs 129 26 infections infection NNS cord-009101-376snefs 129 27 within within IN cord-009101-376snefs 129 28 the the DT cord-009101-376snefs 129 29 community community NN cord-009101-376snefs 129 30 . . . cord-009101-376snefs 130 1 Infected infected JJ cord-009101-376snefs 130 2 visitors visitor NNS cord-009101-376snefs 130 3 and and CC cord-009101-376snefs 130 4 health health NN cord-009101-376snefs 130 5 care care NN cord-009101-376snefs 130 6 workers worker NNS cord-009101-376snefs 130 7 may may MD cord-009101-376snefs 130 8 unknowingly unknowingly RB cord-009101-376snefs 130 9 expose expose VB cord-009101-376snefs 130 10 healthy healthy JJ cord-009101-376snefs 130 11 newborns newborn NNS cord-009101-376snefs 130 12 to to IN cord-009101-376snefs 130 13 respiratory respiratory JJ cord-009101-376snefs 130 14 viruses virus NNS cord-009101-376snefs 130 15 such such JJ cord-009101-376snefs 130 16 as as IN cord-009101-376snefs 130 17 RSV RSV NNP cord-009101-376snefs 130 18 , , , cord-009101-376snefs 130 19 influenza influenza NN cord-009101-376snefs 130 20 , , , cord-009101-376snefs 130 21 and and CC cord-009101-376snefs 130 22 adenovirus adenovirus NN cord-009101-376snefs 130 23 ; ; , cord-009101-376snefs 130 24 enteric enteric JJ cord-009101-376snefs 130 25 viruses virus NNS cord-009101-376snefs 130 26 such such JJ cord-009101-376snefs 130 27 as as IN cord-009101-376snefs 130 28 rotavirus rotavirus NN cord-009101-376snefs 130 29 and and CC cord-009101-376snefs 130 30 enteroviruses enterovirus NNS cord-009101-376snefs 130 31 ; ; : cord-009101-376snefs 130 32 herpes herpes NNP cord-009101-376snefs 130 33 simplex simplex NNP cord-009101-376snefs 130 34 virus virus NN cord-009101-376snefs 130 35 ; ; : cord-009101-376snefs 130 36 and and CC cord-009101-376snefs 130 37 varicella varicella NN cord-009101-376snefs 130 38 virus virus NN cord-009101-376snefs 130 39 ( ( -LRB- cord-009101-376snefs 130 40 Overall Overall NNP cord-009101-376snefs 130 41 , , , cord-009101-376snefs 130 42 1992 1992 CD cord-009101-376snefs 130 43 ) ) -RRB- cord-009101-376snefs 130 44 . . . cord-009101-376snefs 131 1 Early early JJ cord-009101-376snefs 131 2 discharge discharge NN cord-009101-376snefs 131 3 results result NNS cord-009101-376snefs 131 4 in in IN cord-009101-376snefs 131 5 newborns newborn NNS cord-009101-376snefs 131 6 being be VBG cord-009101-376snefs 131 7 discharged discharge VBN cord-009101-376snefs 131 8 before before IN cord-009101-376snefs 131 9 the the DT cord-009101-376snefs 131 10 end end NN cord-009101-376snefs 131 11 of of IN cord-009101-376snefs 131 12 the the DT cord-009101-376snefs 131 13 minimum minimum JJ cord-009101-376snefs 131 14 incubation incubation NN cord-009101-376snefs 131 15 period period NN cord-009101-376snefs 131 16 for for IN cord-009101-376snefs 131 17 most most JJS cord-009101-376snefs 131 18 viruses virus NNS cord-009101-376snefs 131 19 . . . cord-009101-376snefs 132 1 These these DT cord-009101-376snefs 132 2 infants infant NNS cord-009101-376snefs 132 3 often often RB cord-009101-376snefs 132 4 have have VBP cord-009101-376snefs 132 5 symptoms symptom NNS cord-009101-376snefs 132 6 develop develop VB cord-009101-376snefs 132 7 at at IN cord-009101-376snefs 132 8 home home NN cord-009101-376snefs 132 9 . . . cord-009101-376snefs 133 1 Routine routine JJ cord-009101-376snefs 133 2 telephone telephone NN cord-009101-376snefs 133 3 follow follow NN cord-009101-376snefs 133 4 - - HYPH cord-009101-376snefs 133 5 up up NN cord-009101-376snefs 133 6 of of IN cord-009101-376snefs 133 7 discharged discharge VBN cord-009101-376snefs 133 8 newborns newborn NNS cord-009101-376snefs 133 9 may may MD cord-009101-376snefs 133 10 alert alert VB cord-009101-376snefs 133 11 the the DT cord-009101-376snefs 133 12 nursery nursery NN cord-009101-376snefs 133 13 staff staff NN cord-009101-376snefs 133 14 to to IN cord-009101-376snefs 133 15 the the DT cord-009101-376snefs 133 16 presence presence NN cord-009101-376snefs 133 17 of of IN cord-009101-376snefs 133 18 a a DT cord-009101-376snefs 133 19 problem problem NN cord-009101-376snefs 133 20 . . . cord-009101-376snefs 134 1 The the DT cord-009101-376snefs 134 2 NICU NICU NNP cord-009101-376snefs 134 3 is be VBZ cord-009101-376snefs 134 4 especially especially RB cord-009101-376snefs 134 5 susceptible susceptible JJ cord-009101-376snefs 134 6 to to IN cord-009101-376snefs 134 7 nosocomial nosocomial JJ cord-009101-376snefs 134 8 viral viral JJ cord-009101-376snefs 134 9 infections infection NNS cord-009101-376snefs 134 10 for for IN cord-009101-376snefs 134 11 a a DT cord-009101-376snefs 134 12 variety variety NN cord-009101-376snefs 134 13 of of IN cord-009101-376snefs 134 14 reasons reason NNS cord-009101-376snefs 134 15 , , , cord-009101-376snefs 134 16 including include VBG cord-009101-376snefs 134 17 extensive extensive JJ cord-009101-376snefs 134 18 use use NN cord-009101-376snefs 134 19 of of IN cord-009101-376snefs 134 20 invasive invasive JJ cord-009101-376snefs 134 21 technology technology NN cord-009101-376snefs 134 22 for for IN cord-009101-376snefs 134 23 the the DT cord-009101-376snefs 134 24 care care NN cord-009101-376snefs 134 25 of of IN cord-009101-376snefs 134 26 sick sick JJ cord-009101-376snefs 134 27 infants infant NNS cord-009101-376snefs 134 28 , , , cord-009101-376snefs 134 29 a a DT cord-009101-376snefs 134 30 fragile fragile JJ cord-009101-376snefs 134 31 and and CC cord-009101-376snefs 134 32 immunocompromised immunocompromised JJ cord-009101-376snefs 134 33 patient patient JJ cord-009101-376snefs 134 34 population population NN cord-009101-376snefs 134 35 , , , cord-009101-376snefs 134 36 and and CC cord-009101-376snefs 134 37 large large JJ cord-009101-376snefs 134 38 numbers number NNS cord-009101-376snefs 134 39 of of IN cord-009101-376snefs 134 40 health health NN cord-009101-376snefs 134 41 care care NN cord-009101-376snefs 134 42 workers worker NNS cord-009101-376snefs 134 43 and and CC cord-009101-376snefs 134 44 visitors visitor NNS cord-009101-376snefs 134 45 who who WP cord-009101-376snefs 134 46 come come VBP cord-009101-376snefs 134 47 in in IN cord-009101-376snefs 134 48 contact contact NN cord-009101-376snefs 134 49 with with IN cord-009101-376snefs 134 50 the the DT cord-009101-376snefs 134 51 patients patient NNS cord-009101-376snefs 134 52 ( ( -LRB- cord-009101-376snefs 134 53 Guerina Guerina NNP cord-009101-376snefs 134 54 & & CC cord-009101-376snefs 134 55 Goldmann Goldmann NNP cord-009101-376snefs 134 56 , , , cord-009101-376snefs 134 57 1993 1993 CD cord-009101-376snefs 134 58 ; ; : cord-009101-376snefs 134 59 Strodtbeck Strodtbeck NNP cord-009101-376snefs 134 60 , , , cord-009101-376snefs 134 61 1986 1986 CD cord-009101-376snefs 134 62 ) ) -RRB- cord-009101-376snefs 134 63 . . . cord-009101-376snefs 135 1 Newborns newborn NNS cord-009101-376snefs 135 2 with with IN cord-009101-376snefs 135 3 underlying underlie VBG cord-009101-376snefs 135 4 cardiac cardiac JJ cord-009101-376snefs 135 5 and and CC cord-009101-376snefs 135 6 pulmonary pulmonary JJ cord-009101-376snefs 135 7 dysfunction dysfunction NN cord-009101-376snefs 135 8 are be VBP cord-009101-376snefs 135 9 particularly particularly RB cord-009101-376snefs 135 10 at at IN cord-009101-376snefs 135 11 risk risk NN cord-009101-376snefs 135 12 for for IN cord-009101-376snefs 135 13 the the DT cord-009101-376snefs 135 14 development development NN cord-009101-376snefs 135 15 of of IN cord-009101-376snefs 135 16 nosocomial nosocomial JJ cord-009101-376snefs 135 17 viral viral JJ cord-009101-376snefs 135 18 infections infection NNS cord-009101-376snefs 135 19 , , , cord-009101-376snefs 135 20 especially especially RB cord-009101-376snefs 135 21 RSV RSV NNP cord-009101-376snefs 135 22 and and CC cord-009101-376snefs 135 23 CMV CMV NNP cord-009101-376snefs 135 24 ( ( -LRB- cord-009101-376snefs 135 25 Guerina Guerina NNP cord-009101-376snefs 135 26 & & CC cord-009101-376snefs 135 27 Goldmann Goldmann NNP cord-009101-376snefs 135 28 , , , cord-009101-376snefs 135 29 1993 1993 CD cord-009101-376snefs 135 30 ; ; : cord-009101-376snefs 135 31 Smith Smith NNP cord-009101-376snefs 135 32 , , , cord-009101-376snefs 135 33 1993 1993 CD cord-009101-376snefs 135 34 ) ) -RRB- cord-009101-376snefs 135 35 . . . cord-009101-376snefs 136 1 Many many JJ cord-009101-376snefs 136 2 viruses virus NNS cord-009101-376snefs 136 3 have have VBP cord-009101-376snefs 136 4 been be VBN cord-009101-376snefs 136 5 implicated implicate VBN cord-009101-376snefs 136 6 as as IN cord-009101-376snefs 136 7 etiologic etiologic JJ cord-009101-376snefs 136 8 agents agent NNS cord-009101-376snefs 136 9 of of IN cord-009101-376snefs 136 10 nosocomial nosocomial JJ cord-009101-376snefs 136 11 infections infection NNS cord-009101-376snefs 136 12 in in IN cord-009101-376snefs 136 13 the the DT cord-009101-376snefs 136 14 NICU NICU NNP cord-009101-376snefs 136 15 . . . cord-009101-376snefs 137 1 The the DT cord-009101-376snefs 137 2 most most RBS cord-009101-376snefs 137 3 commonly commonly RB cord-009101-376snefs 137 4 identified identify VBN cord-009101-376snefs 137 5 viruses virus NNS cord-009101-376snefs 137 6 are be VBP cord-009101-376snefs 137 7 the the DT cord-009101-376snefs 137 8 respiratory respiratory JJ cord-009101-376snefs 137 9 viruses virus NNS cord-009101-376snefs 137 10 ( ( -LRB- cord-009101-376snefs 137 11 rhinovirus rhinovirus NN cord-009101-376snefs 137 12 , , , cord-009101-376snefs 137 13 adenovirus adenovirus NN cord-009101-376snefs 137 14 , , , cord-009101-376snefs 137 15 RSV RSV NNP cord-009101-376snefs 137 16 , , , cord-009101-376snefs 137 17 parainfluenza parainfluenza NNP cord-009101-376snefs 137 18 , , , cord-009101-376snefs 137 19 and and CC cord-009101-376snefs 137 20 influenza influenza NN cord-009101-376snefs 137 21 virus virus NN cord-009101-376snefs 137 22 ) ) -RRB- cord-009101-376snefs 137 23 ; ; : cord-009101-376snefs 137 24 the the DT cord-009101-376snefs 137 25 enteric enteric JJ cord-009101-376snefs 137 26 viruses virus NNS cord-009101-376snefs 137 27 ( ( -LRB- cord-009101-376snefs 137 28 rotavirus rotavirus NN cord-009101-376snefs 137 29 and and CC cord-009101-376snefs 137 30 coronavirus coronavirus NN cord-009101-376snefs 137 31 ) ) -RRB- cord-009101-376snefs 137 32 ; ; : cord-009101-376snefs 137 33 the the DT cord-009101-376snefs 137 34 enteroviruses enterovirus NNS cord-009101-376snefs 137 35 ; ; : cord-009101-376snefs 137 36 and and CC cord-009101-376snefs 137 37 the the DT cord-009101-376snefs 137 38 herpes herpes NN cord-009101-376snefs 137 39 viruses virus NNS cord-009101-376snefs 137 40 ( ( -LRB- cord-009101-376snefs 137 41 CMV CMV NNP cord-009101-376snefs 137 42 and and CC cord-009101-376snefs 137 43 herpes herpes NNP cord-009101-376snefs 137 44 simplex simplex NNP cord-009101-376snefs 137 45 ) ) -RRB- cord-009101-376snefs 137 46 . . . cord-009101-376snefs 138 1 Nosocomial nosocomial JJ cord-009101-376snefs 138 2 viral viral JJ cord-009101-376snefs 138 3 infections infection NNS cord-009101-376snefs 138 4 are be VBP cord-009101-376snefs 138 5 of of IN cord-009101-376snefs 138 6 concern concern NN cord-009101-376snefs 138 7 because because IN cord-009101-376snefs 138 8 they -PRON- PRP cord-009101-376snefs 138 9 prolong prolong VBP cord-009101-376snefs 138 10 hospital hospital NN cord-009101-376snefs 138 11 stays stay NNS cord-009101-376snefs 138 12 and and CC cord-009101-376snefs 138 13 increase increase VB cord-009101-376snefs 138 14 health health NN cord-009101-376snefs 138 15 care care NN cord-009101-376snefs 138 16 costs cost NNS cord-009101-376snefs 138 17 , , , cord-009101-376snefs 138 18 increase increase VB cord-009101-376snefs 138 19 neonatal neonatal JJ cord-009101-376snefs 138 20 morbidity morbidity NN cord-009101-376snefs 138 21 and and CC cord-009101-376snefs 138 22 mortality mortality NN cord-009101-376snefs 138 23 , , , cord-009101-376snefs 138 24 and and CC cord-009101-376snefs 138 25 are be VBP cord-009101-376snefs 138 26 difficult difficult JJ cord-009101-376snefs 138 27 to to TO cord-009101-376snefs 138 28 recognize recognize VB cord-009101-376snefs 138 29 and and CC cord-009101-376snefs 138 30 diagnose diagnose VB cord-009101-376snefs 138 31 . . . cord-009101-376snefs 139 1 New new JJ cord-009101-376snefs 139 2 evidence evidence NN cord-009101-376snefs 139 3 suggests suggest VBZ cord-009101-376snefs 139 4 that that IN cord-009101-376snefs 139 5 infection infection NN cord-009101-376snefs 139 6 with with IN cord-009101-376snefs 139 7 CMV CMV NNP cord-009101-376snefs 139 8 or or CC cord-009101-376snefs 139 9 influenza influenza NN cord-009101-376snefs 139 10 virus virus NN cord-009101-376snefs 139 11 may may MD cord-009101-376snefs 139 12 complicate complicate VB cord-009101-376snefs 139 13 matters matter NNS cord-009101-376snefs 139 14 by by IN cord-009101-376snefs 139 15 predisposing predispose VBG cord-009101-376snefs 139 16 the the DT cord-009101-376snefs 139 17 critically critically RB cord-009101-376snefs 139 18 ill ill JJ cord-009101-376snefs 139 19 newborn newborn JJ cord-009101-376snefs 139 20 to to IN cord-009101-376snefs 139 21 bacterial bacterial JJ cord-009101-376snefs 139 22 superinfection superinfection NN cord-009101-376snefs 139 23 because because IN cord-009101-376snefs 139 24 of of IN cord-009101-376snefs 139 25 viral viral RB cord-009101-376snefs 139 26 - - HYPH cord-009101-376snefs 139 27 induced induce VBN cord-009101-376snefs 139 28 changes change NNS cord-009101-376snefs 139 29 in in IN cord-009101-376snefs 139 30 polymorphonuclear polymorphonuclear JJ cord-009101-376snefs 139 31 leukocyte leukocyte NN cord-009101-376snefs 139 32 function function NN cord-009101-376snefs 139 33 ( ( -LRB- cord-009101-376snefs 139 34 Abramson Abramson NNP cord-009101-376snefs 139 35 & & CC cord-009101-376snefs 139 36 Wheeler Wheeler NNP cord-009101-376snefs 139 37 , , , cord-009101-376snefs 139 38 1994 1994 CD cord-009101-376snefs 139 39 ) ) -RRB- cord-009101-376snefs 139 40 . . . cord-009101-376snefs 140 1 Reports report NNS cord-009101-376snefs 140 2 of of IN cord-009101-376snefs 140 3 nosocomial nosocomial JJ cord-009101-376snefs 140 4 infection infection NN cord-009101-376snefs 140 5 range range NN cord-009101-376snefs 140 6 from from IN cord-009101-376snefs 140 7 case case NN cord-009101-376snefs 140 8 studies study NNS cord-009101-376snefs 140 9 to to IN cord-009101-376snefs 140 10 unit unit NN cord-009101-376snefs 140 11 outbreaks outbreak NNS cord-009101-376snefs 141 1 ( ( -LRB- cord-009101-376snefs 141 2 Singh Singh NNP cord-009101-376snefs 141 3 - - HYPH cord-009101-376snefs 141 4 Naz Naz NNP cord-009101-376snefs 141 5 , , , cord-009101-376snefs 141 6 Brown Brown NNP cord-009101-376snefs 141 7 , , , cord-009101-376snefs 141 8 & & CC cord-009101-376snefs 141 9 Ganeshananthan Ganeshananthan NNP cord-009101-376snefs 141 10 , , , cord-009101-376snefs 141 11 1993 1993 CD cord-009101-376snefs 141 12 ; ; : cord-009101-376snefs 141 13 Strodtbeck Strodtbeck NNP cord-009101-376snefs 141 14 , , , cord-009101-376snefs 141 15 5 5 CD cord-009101-376snefs 141 16 8 8 CD cord-009101-376snefs 141 17 6 6 CD cord-009101-376snefs 141 18 ; ; : cord-009101-376snefs 141 19 Watson Watson NNP cord-009101-376snefs 141 20 et et NNP cord-009101-376snefs 141 21 al al NNP cord-009101-376snefs 141 22 . . NNP cord-009101-376snefs 141 23 , , , cord-009101-376snefs 141 24 1993 1993 CD cord-009101-376snefs 141 25 ) ) -RRB- cord-009101-376snefs 141 26 . . . cord-009101-376snefs 142 1 Risk risk NN cord-009101-376snefs 142 2 factors factor NNS cord-009101-376snefs 142 3 linked link VBN cord-009101-376snefs 142 4 to to IN cord-009101-376snefs 142 5 nosocomial nosocomial JJ cord-009101-376snefs 142 6 viral viral JJ cord-009101-376snefs 142 7 infections infection NNS cord-009101-376snefs 142 8 include include VBP cord-009101-376snefs 142 9 intubation intubation NN cord-009101-376snefs 142 10 and and CC cord-009101-376snefs 142 11 assisted assisted JJ cord-009101-376snefs 142 12 ventilation ventilation NN cord-009101-376snefs 142 13 ; ; : cord-009101-376snefs 142 14 transfusion transfusion NN cord-009101-376snefs 142 15 with with IN cord-009101-376snefs 142 16 CMV CMV NNP cord-009101-376snefs 142 17 - - HYPH cord-009101-376snefs 142 18 positive positive JJ cord-009101-376snefs 142 19 donor donor NN cord-009101-376snefs 142 20 blood blood NN cord-009101-376snefs 142 21 ; ; : cord-009101-376snefs 142 22 ingestion ingestion NN cord-009101-376snefs 142 23 of of IN cord-009101-376snefs 142 24 contaminated contaminated JJ cord-009101-376snefs 142 25 breast breast NN cord-009101-376snefs 142 26 milk milk NN cord-009101-376snefs 142 27 ; ; : cord-009101-376snefs 142 28 direct direct JJ cord-009101-376snefs 142 29 and and CC cord-009101-376snefs 142 30 indirect indirect JJ cord-009101-376snefs 142 31 contact contact NN cord-009101-376snefs 142 32 among among IN cord-009101-376snefs 142 33 patients patient NNS cord-009101-376snefs 142 34 , , , cord-009101-376snefs 142 35 visitors visitor NNS cord-009101-376snefs 142 36 , , , cord-009101-376snefs 142 37 and and CC cord-009101-376snefs 142 38 hospital hospital NN cord-009101-376snefs 142 39 personnel personnel NNS cord-009101-376snefs 142 40 ; ; : cord-009101-376snefs 142 41 contact contact NN cord-009101-376snefs 142 42 with with IN cord-009101-376snefs 142 43 contaminated contaminated JJ cord-009101-376snefs 142 44 objects object NNS cord-009101-376snefs 142 45 in in IN cord-009101-376snefs 142 46 the the DT cord-009101-376snefs 142 47 environment environment NN cord-009101-376snefs 142 48 ; ; : cord-009101-376snefs 142 49 and and CC cord-009101-376snefs 142 50 inadequate inadequate JJ cord-009101-376snefs 142 51 hand hand NN cord-009101-376snefs 142 52 washing washing NN cord-009101-376snefs 142 53 ( ( -LRB- cord-009101-376snefs 142 54 Guerina Guerina NNP cord-009101-376snefs 142 55 & & CC cord-009101-376snefs 142 56 Goldmann Goldmann NNP cord-009101-376snefs 142 57 , , , cord-009101-376snefs 142 58 1993 1993 CD cord-009101-376snefs 142 59 ; ; : cord-009101-376snefs 142 60 Strodtbeck Strodtbeck NNP cord-009101-376snefs 142 61 , , , cord-009101-376snefs 142 62 1986 1986 CD cord-009101-376snefs 142 63 ) ) -RRB- cord-009101-376snefs 142 64 . . . cord-009101-376snefs 143 1 Nursing nursing NN cord-009101-376snefs 143 2 care care NN cord-009101-376snefs 143 3 of of IN cord-009101-376snefs 143 4 the the DT cord-009101-376snefs 143 5 newborn newborn NN cord-009101-376snefs 143 6 with with IN cord-009101-376snefs 143 7 severe severe JJ cord-009101-376snefs 143 8 viral viral JJ cord-009101-376snefs 143 9 disease disease NN cord-009101-376snefs 143 10 is be VBZ cord-009101-376snefs 143 11 complex complex JJ cord-009101-376snefs 143 12 and and CC cord-009101-376snefs 143 13 varies vary VBZ cord-009101-376snefs 143 14 according accord VBG cord-009101-376snefs 143 15 to to IN cord-009101-376snefs 143 16 the the DT cord-009101-376snefs 143 17 clinical clinical JJ cord-009101-376snefs 143 18 presentation presentation NN cord-009101-376snefs 143 19 of of IN cord-009101-376snefs 143 20 the the DT cord-009101-376snefs 143 21 neonate neonate NN cord-009101-376snefs 143 22 . . . cord-009101-376snefs 144 1 Each each DT cord-009101-376snefs 144 2 year year NN cord-009101-376snefs 144 3 significant significant JJ cord-009101-376snefs 144 4 neonatal neonatal JJ cord-009101-376snefs 144 5 morbidity morbidity NN cord-009101-376snefs 144 6 and and CC cord-009101-376snefs 144 7 mortality mortality NN cord-009101-376snefs 144 8 occur occur VBP cord-009101-376snefs 144 9 as as IN cord-009101-376snefs 144 10 a a DT cord-009101-376snefs 144 11 result result NN cord-009101-376snefs 144 12 of of IN cord-009101-376snefs 144 13 viral viral JJ cord-009101-376snefs 144 14 infections infection NNS cord-009101-376snefs 144 15 . . . cord-009101-376snefs 145 1 The the DT cord-009101-376snefs 145 2 presence presence NN cord-009101-376snefs 145 3 of of IN cord-009101-376snefs 145 4 a a DT cord-009101-376snefs 145 5 developing develop VBG cord-009101-376snefs 145 6 immune immune JJ cord-009101-376snefs 145 7 system system NN cord-009101-376snefs 145 8 inexperienced inexperienced JJ cord-009101-376snefs 145 9 in in IN cord-009101-376snefs 145 10 response response NN cord-009101-376snefs 145 11 to to IN cord-009101-376snefs 145 12 viruses virus NNS cord-009101-376snefs 145 13 in in IN cord-009101-376snefs 145 14 a a DT cord-009101-376snefs 145 15 rapidly rapidly RB cord-009101-376snefs 145 16 growing grow VBG cord-009101-376snefs 145 17 host host NN cord-009101-376snefs 145 18 make make VBP cord-009101-376snefs 145 19 the the DT cord-009101-376snefs 145 20 newborn newborn JJ cord-009101-376snefs 145 21 especially especially RB cord-009101-376snefs 145 22 vulnerable vulnerable JJ cord-009101-376snefs 145 23 to to IN cord-009101-376snefs 145 24 viral viral JJ cord-009101-376snefs 145 25 disease disease NN cord-009101-376snefs 145 26 . . . cord-009101-376snefs 146 1 The the DT cord-009101-376snefs 146 2 effects effect NNS cord-009101-376snefs 146 3 of of IN cord-009101-376snefs 146 4 viral viral JJ cord-009101-376snefs 146 5 infection infection NN cord-009101-376snefs 146 6 are be VBP cord-009101-376snefs 146 7 varied varied JJ cord-009101-376snefs 146 8 and and CC cord-009101-376snefs 146 9 range range VB cord-009101-376snefs 146 10 from from IN cord-009101-376snefs 146 11 no no DT cord-009101-376snefs 146 12 symptoms symptom NNS cord-009101-376snefs 146 13 to to TO cord-009101-376snefs 146 14 mild mild JJ cord-009101-376snefs 146 15 or or CC cord-009101-376snefs 146 16 severe severe JJ cord-009101-376snefs 146 17 disease disease NN cord-009101-376snefs 146 18 . . . cord-009101-376snefs 147 1 Although although IN cord-009101-376snefs 147 2 the the DT cord-009101-376snefs 147 3 newborn newborn JJ cord-009101-376snefs 147 4 immune immune JJ cord-009101-376snefs 147 5 system system NN cord-009101-376snefs 147 6 is be VBZ cord-009101-376snefs 147 7 capable capable JJ cord-009101-376snefs 147 8 of of IN cord-009101-376snefs 147 9 mounting mount VBG cord-009101-376snefs 147 10 a a DT cord-009101-376snefs 147 11 defense defense NN cord-009101-376snefs 147 12 to to IN cord-009101-376snefs 147 13 the the DT cord-009101-376snefs 147 14 virus virus NN cord-009101-376snefs 147 15 , , , cord-009101-376snefs 147 16 the the DT cord-009101-376snefs 147 17 response response NN cord-009101-376snefs 147 18 often often RB cord-009101-376snefs 147 19 is be VBZ cord-009101-376snefs 147 20 inadequate inadequate JJ cord-009101-376snefs 147 21 for for IN cord-009101-376snefs 147 22 preventing prevent VBG cord-009101-376snefs 147 23 infection infection NN cord-009101-376snefs 147 24 . . . cord-009101-376snefs 148 1 The the DT cord-009101-376snefs 148 2 outcome outcome NN cord-009101-376snefs 148 3 of of IN cord-009101-376snefs 148 4 viral viral JJ cord-009101-376snefs 148 5 infection infection NN cord-009101-376snefs 148 6 depends depend VBZ cord-009101-376snefs 148 7 upon upon IN cord-009101-376snefs 148 8 the the DT cord-009101-376snefs 148 9 specific specific JJ cord-009101-376snefs 148 10 virus virus NN cord-009101-376snefs 148 11 , , , cord-009101-376snefs 148 12 the the DT cord-009101-376snefs 148 13 gestational gestational JJ cord-009101-376snefs 148 14 age age NN cord-009101-376snefs 148 15 of of IN cord-009101-376snefs 148 16 the the DT cord-009101-376snefs 148 17 newborn newborn NN cord-009101-376snefs 148 18 at at IN cord-009101-376snefs 148 19 the the DT cord-009101-376snefs 148 20 onset onset NN cord-009101-376snefs 148 21 of of IN cord-009101-376snefs 148 22 infection infection NN cord-009101-376snefs 148 23 , , , cord-009101-376snefs 148 24 and and CC cord-009101-376snefs 148 25 the the DT cord-009101-376snefs 148 26 severity severity NN cord-009101-376snefs 148 27 of of IN cord-009101-376snefs 148 28 the the DT cord-009101-376snefs 148 29 infection infection NN cord-009101-376snefs 148 30 . . . cord-009101-376snefs 149 1 In in IN cord-009101-376snefs 149 2 addition addition NN cord-009101-376snefs 149 3 to to IN cord-009101-376snefs 149 4 limited limited JJ cord-009101-376snefs 149 5 specific specific JJ cord-009101-376snefs 149 6 antiviral antiviral JJ cord-009101-376snefs 149 7 drug drug NN cord-009101-376snefs 149 8 therapy therapy NN cord-009101-376snefs 149 9 , , , cord-009101-376snefs 149 10 many many JJ cord-009101-376snefs 149 11 of of IN cord-009101-376snefs 149 12 the the DT cord-009101-376snefs 149 13 available available JJ cord-009101-376snefs 149 14 drugs drug NNS cord-009101-376snefs 149 15 are be VBP cord-009101-376snefs 149 16 not not RB cord-009101-376snefs 149 17 recommended recommend VBN cord-009101-376snefs 149 18 for for IN cord-009101-376snefs 149 19 use use NN cord-009101-376snefs 149 20 in in IN cord-009101-376snefs 149 21 newborns newborn NNS cord-009101-376snefs 149 22 . . . cord-009101-376snefs 150 1 Several several JJ cord-009101-376snefs 150 2 new new JJ cord-009101-376snefs 150 3 therapies therapy NNS cord-009101-376snefs 150 4 are be VBP cord-009101-376snefs 150 5 being be VBG cord-009101-376snefs 150 6 tested test VBN cord-009101-376snefs 150 7 and and CC cord-009101-376snefs 150 8 show show VB cord-009101-376snefs 150 9 promise promise NN cord-009101-376snefs 150 10 ; ; : cord-009101-376snefs 150 11 eventually eventually RB cord-009101-376snefs 150 12 they -PRON- PRP cord-009101-376snefs 150 13 may may MD cord-009101-376snefs 150 14 lessen lessen VB cord-009101-376snefs 150 15 the the DT cord-009101-376snefs 150 16 severity severity NN cord-009101-376snefs 150 17 of of IN cord-009101-376snefs 150 18 disseminated disseminate VBN cord-009101-376snefs 150 19 disease disease NN cord-009101-376snefs 150 20 and and CC cord-009101-376snefs 150 21 minimize minimize VB cord-009101-376snefs 150 22 the the DT cord-009101-376snefs 150 23 long long JJ cord-009101-376snefs 150 24 - - HYPH cord-009101-376snefs 150 25 term term NN cord-009101-376snefs 150 26 sequelae sequela NNS cord-009101-376snefs 150 27 . . . cord-009101-376snefs 151 1 Until until IN cord-009101-376snefs 151 2 such such JJ cord-009101-376snefs 151 3 time time NN cord-009101-376snefs 151 4 , , , cord-009101-376snefs 151 5 the the DT cord-009101-376snefs 151 6 major major JJ cord-009101-376snefs 151 7 thrusts thrust NNS cord-009101-376snefs 151 8 of of IN cord-009101-376snefs 151 9 management management NN cord-009101-376snefs 151 10 of of IN cord-009101-376snefs 151 11 neonatal neonatal JJ cord-009101-376snefs 151 12 viral viral JJ cord-009101-376snefs 151 13 disease disease NN cord-009101-376snefs 151 14 are be VBP cord-009101-376snefs 151 15 prevention prevention NN cord-009101-376snefs 151 16 of of IN cord-009101-376snefs 151 17 the the DT cord-009101-376snefs 151 18 infection infection NN cord-009101-376snefs 151 19 and and CC cord-009101-376snefs 151 20 supportive supportive JJ cord-009101-376snefs 151 21 care care NN cord-009101-376snefs 151 22 for for IN cord-009101-376snefs 151 23 the the DT cord-009101-376snefs 151 24 acutely acutely RB cord-009101-376snefs 151 25 ill ill JJ cord-009101-376snefs 151 26 newborn newborn JJ cord-009101-376snefs 151 27 . . . cord-009101-376snefs 152 1 Virus virus NN cord-009101-376snefs 152 2 - - HYPH cord-009101-376snefs 152 3 induced induce VBN cord-009101-376snefs 152 4 neutro neutro NNP cord-009101-376snefs 152 5 - - HYPH cord-009101-376snefs 152 6 phi1 phi1 NNP cord-009101-376snefs 152 7 dysfunction dysfunction NN cord-009101-376snefs 152 8 : : : cord-009101-376snefs 152 9 Role role NN cord-009101-376snefs 152 10 in in IN cord-009101-376snefs 152 11 the the DT cord-009101-376snefs 152 12 pathogenesis pathogenesis NN cord-009101-376snefs 152 13 of of IN cord-009101-376snefs 152 14 bacterial bacterial JJ cord-009101-376snefs 152 15 infections infection NNS cord-009101-376snefs 152 16 The the DT cord-009101-376snefs 152 17 1994 1994 CD cord-009101-376snefs 152 18 red red JJ cord-009101-376snefs 152 19 book book NN cord-009101-376snefs 152 20 Other other JJ cord-009101-376snefs 152 21 viral viral JJ cord-009101-376snefs 152 22 infections infection NNS cord-009101-376snefs 152 23 of of IN cord-009101-376snefs 152 24 the the DT cord-009101-376snefs 152 25 fetus fetus NN cord-009101-376snefs 152 26 and and CC cord-009101-376snefs 152 27 newborn newborn JJ cord-009101-376snefs 152 28 Enteroviruses Enteroviruses NNP cord-009101-376snefs 152 29 Infectious infectious JJ cord-009101-376snefs 152 30 diseases disease NNS cord-009101-376snefs 152 31 of of IN cord-009101-376snefs 152 32 the the DT cord-009101-376snefs 152 33 fetus fetus NN cord-009101-376snefs 152 34 and and CC cord-009101-376snefs 152 35 newborn newborn JJ cord-009101-376snefs 152 36 infant infant NN cord-009101-376snefs 152 37 Rubella rubella NN cord-009101-376snefs 152 38 Respiratorysyncytial Respiratorysyncytial NNP cord-009101-376snefs 152 39 virus virus NN cord-009101-376snefs 152 40 Chickenpox chickenpox NN cord-009101-376snefs 152 41 , , , cord-009101-376snefs 152 42 measles measle NNS cord-009101-376snefs 152 43 and and CC cord-009101-376snefs 152 44 mumps mumps NN cord-009101-376snefs 152 45 Uncommon uncommon JJ cord-009101-376snefs 152 46 pathogens pathogen NNS cord-009101-376snefs 152 47 in in IN cord-009101-376snefs 152 48 newborn newborn JJ cord-009101-376snefs 152 49 infants infant NNS cord-009101-376snefs 152 50 Neonatal neonatal JJ cord-009101-376snefs 152 51 nosocomial nosocomial JJ cord-009101-376snefs 152 52 infections infection NNS cord-009101-376snefs 152 53 : : : cord-009101-376snefs 152 54 Prevention prevention NN cord-009101-376snefs 152 55 and and CC cord-009101-376snefs 152 56 management management NN cord-009101-376snefs 152 57 Current current JJ cord-009101-376snefs 152 58 therapy therapy NN cord-009101-376snefs 152 59 in in IN cord-009101-376snefs 152 60 pediatric pediatric JJ cord-009101-376snefs 152 61 infectious infectious JJ cord-009101-376snefs 152 62 disease disease NN cord-009101-376snefs 152 63 Enteric enteric JJ cord-009101-376snefs 152 64 infectious infectious JJ cord-009101-376snefs 152 65 disease disease NN cord-009101-376snefs 152 66 in in IN cord-009101-376snefs 152 67 neonates neonate NNS cord-009101-376snefs 152 68 : : : cord-009101-376snefs 152 69 Epidemiology epidemiology NN cord-009101-376snefs 152 70 , , , cord-009101-376snefs 152 71 pathogenesis pathogenesis NN cord-009101-376snefs 152 72 , , , cord-009101-376snefs 152 73 and and CC cord-009101-376snefs 152 74 a a DT cord-009101-376snefs 152 75 practical practical JJ cord-009101-376snefs 152 76 approach approach NN cord-009101-376snefs 152 77 to to IN cord-009101-376snefs 152 78 evaluation evaluation NN cord-009101-376snefs 152 79 and and CC cord-009101-376snefs 152 80 therapy therapy NN cord-009101-376snefs 152 81 Acquired acquire VBN cord-009101-376snefs 152 82 immunodeficiency immunodeficiency NN cord-009101-376snefs 152 83 syndrome syndrome NN cord-009101-376snefs 152 84 in in IN cord-009101-376snefs 152 85 the the DT cord-009101-376snefs 152 86 infant infant NN cord-009101-376snefs 152 87 Viral viral JJ cord-009101-376snefs 152 88 infections infection NNS cord-009101-376snefs 152 89 of of IN cord-009101-376snefs 152 90 the the DT cord-009101-376snefs 152 91 fetus fetus NN cord-009101-376snefs 152 92 and and CC cord-009101-376snefs 152 93 neonate neonate NN cord-009101-376snefs 152 94 Nosocomial nosocomial JJ cord-009101-376snefs 152 95 adenovirus adenovirus NN cord-009101-376snefs 152 96 infection infection NN cord-009101-376snefs 152 97 : : : cord-009101-376snefs 152 98 Molecular molecular JJ cord-009101-376snefs 152 99 epidemiology epidemiology NN cord-009101-376snefs 152 100 of of IN cord-009101-376snefs 152 101 an an DT cord-009101-376snefs 152 102 outbreak outbreak NN cord-009101-376snefs 152 103 Congenital congenital JJ cord-009101-376snefs 152 104 viral viral JJ cord-009101-376snefs 152 105 and and CC cord-009101-376snefs 152 106 protozoan protozoan NN cord-009101-376snefs 152 107 infections infection NNS cord-009101-376snefs 153 1 Cytomegalovirus Cytomegalovirus NNP cord-009101-376snefs 153 2 The the DT cord-009101-376snefs 153 3 epidemiology epidemiology NN cord-009101-376snefs 153 4 of of IN cord-009101-376snefs 153 5 nosocomial nosocomial JJ cord-009101-376snefs 153 6 viral viral JJ cord-009101-376snefs 153 7 infections infection NNS cord-009101-376snefs 153 8 in in IN cord-009101-376snefs 153 9 infants infant NNS cord-009101-376snefs 153 10 who who WP cord-009101-376snefs 153 11 are be VBP cord-009101-376snefs 153 12 long long JJ cord-009101-376snefs 153 13 term term NN cord-009101-376snefs 153 14 residents resident NNS cord-009101-376snefs 153 15 of of IN cord-009101-376snefs 153 16 the the DT cord-009101-376snefs 153 17 neonatal neonatal JJ cord-009101-376snefs 153 18 intensive intensive JJ cord-009101-376snefs 153 19 care care NN cord-009101-376snefs 153 20 unit unit NN cord-009101-376snefs 153 21 Human human JJ cord-009101-376snefs 153 22 parvovirus parvovirus NN cord-009101-376snefs 153 23 Bl9 bl9 NN cord-009101-376snefs 154 1 The the DT cord-009101-376snefs 154 2 biology biology NN cord-009101-376snefs 154 3 of of IN cord-009101-376snefs 154 4 viruses virus NNS cord-009101-376snefs 155 1 Vertical vertical JJ cord-009101-376snefs 155 2 transmission transmission NN cord-009101-376snefs 155 3 of of IN cord-009101-376snefs 155 4 hepatitis hepatitis NN cord-009101-376snefs 155 5 A A NNP cord-009101-376snefs 155 6 resulting result VBG cord-009101-376snefs 155 7 in in IN cord-009101-376snefs 155 8 an an DT cord-009101-376snefs 155 9 outbreak outbreak NN cord-009101-376snefs 155 10 in in IN cord-009101-376snefs 155 11 a a DT cord-009101-376snefs 155 12 neonatal neonatal JJ cord-009101-376snefs 155 13 intensive intensive JJ cord-009101-376snefs 155 14 care care NN cord-009101-376snefs 155 15 unit unit NN cord-009101-376snefs 155 16 Herpes Herpes NNP cord-009101-376snefs 155 17 simplexvirus simplexvirus NNP cord-009101-376snefs 155 18 infection infection NN