id sid tid token lemma pos cord-007796-zggk0x2q 1 1 key key NN cord-007796-zggk0x2q 1 2 : : : cord-007796-zggk0x2q 2 1 cord-007796-zggk0x2q cord-007796-zggk0x2q JJ cord-007796-zggk0x2q 2 2 authors author NNS cord-007796-zggk0x2q 2 3 : : : cord-007796-zggk0x2q 2 4 Lindemans Lindemans NNPS cord-007796-zggk0x2q 2 5 , , , cord-007796-zggk0x2q 2 6 Caroline Caroline NNP cord-007796-zggk0x2q 2 7 A. a. NN cord-007796-zggk0x2q 2 8 ; ; : cord-007796-zggk0x2q 2 9 Kimpen Kimpen NNP cord-007796-zggk0x2q 2 10 , , , cord-007796-zggk0x2q 2 11 Jan Jan NNP cord-007796-zggk0x2q 2 12 L. L. NNP cord-007796-zggk0x2q 2 13 L. L. NNP cord-007796-zggk0x2q 3 1 title title NN cord-007796-zggk0x2q 3 2 : : : cord-007796-zggk0x2q 3 3 The the DT cord-007796-zggk0x2q 3 4 Immune Immune NNP cord-007796-zggk0x2q 3 5 Response response NN cord-007796-zggk0x2q 3 6 to to IN cord-007796-zggk0x2q 3 7 Viral Viral NNP cord-007796-zggk0x2q 3 8 Lower low JJR cord-007796-zggk0x2q 3 9 Respiratory respiratory JJ cord-007796-zggk0x2q 3 10 Tract tract NN cord-007796-zggk0x2q 3 11 Infection infection NN cord-007796-zggk0x2q 3 12 date date NN cord-007796-zggk0x2q 3 13 : : : cord-007796-zggk0x2q 4 1 2005 2005 CD cord-007796-zggk0x2q 4 2 journal journal NNP cord-007796-zggk0x2q 4 3 : : : cord-007796-zggk0x2q 5 1 Hot hot JJ cord-007796-zggk0x2q 5 2 Topics topic NNS cord-007796-zggk0x2q 5 3 in in IN cord-007796-zggk0x2q 5 4 Infection infection NN cord-007796-zggk0x2q 5 5 and and CC cord-007796-zggk0x2q 5 6 Immunity Immunity NNP cord-007796-zggk0x2q 5 7 in in IN cord-007796-zggk0x2q 5 8 Children Children NNP cord-007796-zggk0x2q 5 9 II II NNP cord-007796-zggk0x2q 6 1 DOI DOI NNP cord-007796-zggk0x2q 6 2 : : : cord-007796-zggk0x2q 7 1 10.1007/0 10.1007/0 CD cord-007796-zggk0x2q 7 2 - - SYM cord-007796-zggk0x2q 7 3 387 387 CD cord-007796-zggk0x2q 7 4 - - HYPH cord-007796-zggk0x2q 7 5 25342 25342 CD cord-007796-zggk0x2q 8 1 -4_4 -4_4 NNPS cord-007796-zggk0x2q 8 2 sha sha NNP cord-007796-zggk0x2q 8 3 : : : cord-007796-zggk0x2q 9 1 30c5620fbf7b2ba76bc0090dc0a5583ea8597289 30c5620fbf7b2ba76bc0090dc0a5583ea8597289 NNP cord-007796-zggk0x2q 9 2 doc_id doc_id NNP cord-007796-zggk0x2q 9 3 : : : cord-007796-zggk0x2q 9 4 7796 7796 CD cord-007796-zggk0x2q 9 5 cord_uid cord_uid NNS cord-007796-zggk0x2q 9 6 : : : cord-007796-zggk0x2q 10 1 zggk0x2q zggk0x2q XX cord-007796-zggk0x2q 11 1 Viruses virus NNS cord-007796-zggk0x2q 11 2 are be VBP cord-007796-zggk0x2q 11 3 responsible responsible JJ cord-007796-zggk0x2q 11 4 for for IN cord-007796-zggk0x2q 11 5 the the DT cord-007796-zggk0x2q 11 6 majority majority NN cord-007796-zggk0x2q 11 7 of of IN cord-007796-zggk0x2q 11 8 respiratory respiratory JJ cord-007796-zggk0x2q 11 9 infections infection NNS cord-007796-zggk0x2q 11 10 in in IN cord-007796-zggk0x2q 11 11 childhood childhood NN cord-007796-zggk0x2q 11 12 , , , cord-007796-zggk0x2q 11 13 causing cause VBG cord-007796-zggk0x2q 11 14 considerable considerable JJ cord-007796-zggk0x2q 11 15 morbidity morbidity NN cord-007796-zggk0x2q 11 16 and and CC cord-007796-zggk0x2q 11 17 mortality mortality NN cord-007796-zggk0x2q 11 18 . . . cord-007796-zggk0x2q 12 1 It -PRON- PRP cord-007796-zggk0x2q 12 2 is be VBZ cord-007796-zggk0x2q 12 3 estimated estimate VBN cord-007796-zggk0x2q 12 4 that that IN cord-007796-zggk0x2q 12 5 in in IN cord-007796-zggk0x2q 12 6 the the DT cord-007796-zggk0x2q 12 7 United United NNP cord-007796-zggk0x2q 12 8 States States NNP cord-007796-zggk0x2q 12 9 approximately approximately RB cord-007796-zggk0x2q 12 10 $ $ $ cord-007796-zggk0x2q 12 11 652 652 CD cord-007796-zggk0x2q 12 12 million million CD cord-007796-zggk0x2q 12 13 per per IN cord-007796-zggk0x2q 12 14 year year NN cord-007796-zggk0x2q 12 15 is be VBZ cord-007796-zggk0x2q 12 16 spent spend VBN cord-007796-zggk0x2q 12 17 on on IN cord-007796-zggk0x2q 12 18 medical medical JJ cord-007796-zggk0x2q 12 19 costs cost NNS cord-007796-zggk0x2q 12 20 for for IN cord-007796-zggk0x2q 12 21 respiratory respiratory JJ cord-007796-zggk0x2q 12 22 syncytial syncytial JJ cord-007796-zggk0x2q 12 23 virus virus NN cord-007796-zggk0x2q 12 24 ( ( -LRB- cord-007796-zggk0x2q 12 25 RSV RSV NNP cord-007796-zggk0x2q 12 26 ) ) -RRB- cord-007796-zggk0x2q 12 27 related relate VBN cord-007796-zggk0x2q 12 28 disease disease NN cord-007796-zggk0x2q 12 29 alone alone RB cord-007796-zggk0x2q 13 1 ( ( -LRB- cord-007796-zggk0x2q 13 2 Paramore Paramore NNP cord-007796-zggk0x2q 13 3 et et NNP cord-007796-zggk0x2q 13 4 al al NNP cord-007796-zggk0x2q 13 5 . . NNP cord-007796-zggk0x2q 13 6 , , , cord-007796-zggk0x2q 13 7 2004 2004 CD cord-007796-zggk0x2q 13 8 ) ) -RRB- cord-007796-zggk0x2q 13 9 . . . cord-007796-zggk0x2q 14 1 Viruses virus NNS cord-007796-zggk0x2q 14 2 cause cause VBP cord-007796-zggk0x2q 14 3 a a DT cord-007796-zggk0x2q 14 4 variety variety NN cord-007796-zggk0x2q 14 5 of of IN cord-007796-zggk0x2q 14 6 respiratory respiratory JJ cord-007796-zggk0x2q 14 7 diseases disease NNS cord-007796-zggk0x2q 14 8 in in IN cord-007796-zggk0x2q 14 9 children child NNS cord-007796-zggk0x2q 14 10 from from IN cord-007796-zggk0x2q 14 11 the the DT cord-007796-zggk0x2q 14 12 common common JJ cord-007796-zggk0x2q 14 13 cold cold NN cord-007796-zggk0x2q 14 14 to to IN cord-007796-zggk0x2q 14 15 life life NN cord-007796-zggk0x2q 14 16 - - HYPH cord-007796-zggk0x2q 14 17 threatening threaten VBG cord-007796-zggk0x2q 14 18 pneumonia pneumonia NN cord-007796-zggk0x2q 14 19 and and CC cord-007796-zggk0x2q 14 20 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 14 21 . . . cord-007796-zggk0x2q 15 1 The the DT cord-007796-zggk0x2q 15 2 host host NN cord-007796-zggk0x2q 15 3 reacts react VBZ cord-007796-zggk0x2q 15 4 to to IN cord-007796-zggk0x2q 15 5 a a DT cord-007796-zggk0x2q 15 6 viral viral JJ cord-007796-zggk0x2q 15 7 infection infection NN cord-007796-zggk0x2q 15 8 with with IN cord-007796-zggk0x2q 15 9 a a DT cord-007796-zggk0x2q 15 10 combination combination NN cord-007796-zggk0x2q 15 11 of of IN cord-007796-zggk0x2q 15 12 innate innate JJ cord-007796-zggk0x2q 15 13 and and CC cord-007796-zggk0x2q 15 14 adaptive adaptive JJ cord-007796-zggk0x2q 15 15 immune immune JJ cord-007796-zggk0x2q 15 16 mechanisms mechanism NNS cord-007796-zggk0x2q 15 17 , , , cord-007796-zggk0x2q 15 18 usually usually RB cord-007796-zggk0x2q 15 19 resulting result VBG cord-007796-zggk0x2q 15 20 in in IN cord-007796-zggk0x2q 15 21 the the DT cord-007796-zggk0x2q 15 22 clearance clearance NN cord-007796-zggk0x2q 15 23 of of IN cord-007796-zggk0x2q 15 24 the the DT cord-007796-zggk0x2q 15 25 virus virus NN cord-007796-zggk0x2q 15 26 and and CC cord-007796-zggk0x2q 15 27 clinical clinical JJ cord-007796-zggk0x2q 15 28 recovery recovery NN cord-007796-zggk0x2q 15 29 . . . cord-007796-zggk0x2q 16 1 However however RB cord-007796-zggk0x2q 16 2 , , , cord-007796-zggk0x2q 16 3 there there EX cord-007796-zggk0x2q 16 4 is be VBZ cord-007796-zggk0x2q 16 5 an an DT cord-007796-zggk0x2q 16 6 accumulating accumulate VBG cord-007796-zggk0x2q 16 7 evidence evidence NN cord-007796-zggk0x2q 16 8 for for IN cord-007796-zggk0x2q 16 9 a a DT cord-007796-zggk0x2q 16 10 number number NN cord-007796-zggk0x2q 16 11 of of IN cord-007796-zggk0x2q 16 12 viral viral JJ cord-007796-zggk0x2q 16 13 infections infection NNS cord-007796-zggk0x2q 16 14 that that WDT cord-007796-zggk0x2q 16 15 the the DT cord-007796-zggk0x2q 16 16 host host NN cord-007796-zggk0x2q 16 17 immune immune JJ cord-007796-zggk0x2q 16 18 response response NN cord-007796-zggk0x2q 16 19 actually actually RB cord-007796-zggk0x2q 16 20 enhances enhance VBZ cord-007796-zggk0x2q 16 21 disease disease NN cord-007796-zggk0x2q 16 22 in in IN cord-007796-zggk0x2q 16 23 the the DT cord-007796-zggk0x2q 16 24 course course NN cord-007796-zggk0x2q 16 25 of of IN cord-007796-zggk0x2q 16 26 clearing clear VBG cord-007796-zggk0x2q 16 27 virus virus NN cord-007796-zggk0x2q 16 28 from from IN cord-007796-zggk0x2q 16 29 the the DT cord-007796-zggk0x2q 16 30 infected infected JJ cord-007796-zggk0x2q 16 31 organs organ NNS cord-007796-zggk0x2q 16 32 . . . cord-007796-zggk0x2q 17 1 Interestingly interestingly RB cord-007796-zggk0x2q 17 2 , , , cord-007796-zggk0x2q 17 3 the the DT cord-007796-zggk0x2q 17 4 effectiveness effectiveness NN cord-007796-zggk0x2q 17 5 of of IN cord-007796-zggk0x2q 17 6 the the DT cord-007796-zggk0x2q 17 7 immune immune JJ cord-007796-zggk0x2q 17 8 response response NN cord-007796-zggk0x2q 17 9 seems seem VBZ cord-007796-zggk0x2q 17 10 to to TO cord-007796-zggk0x2q 17 11 be be VB cord-007796-zggk0x2q 17 12 dependent dependent JJ cord-007796-zggk0x2q 17 13 on on IN cord-007796-zggk0x2q 17 14 the the DT cord-007796-zggk0x2q 17 15 age age NN cord-007796-zggk0x2q 17 16 and and CC cord-007796-zggk0x2q 17 17 probably probably RB cord-007796-zggk0x2q 17 18 genetic genetic JJ cord-007796-zggk0x2q 17 19 background background NN cord-007796-zggk0x2q 17 20 of of IN cord-007796-zggk0x2q 17 21 the the DT cord-007796-zggk0x2q 17 22 child child NN cord-007796-zggk0x2q 17 23 . . . cord-007796-zggk0x2q 18 1 This this DT cord-007796-zggk0x2q 18 2 has have VBZ cord-007796-zggk0x2q 18 3 important important JJ cord-007796-zggk0x2q 18 4 implications implication NNS cord-007796-zggk0x2q 18 5 for for IN cord-007796-zggk0x2q 18 6 treatment treatment NN cord-007796-zggk0x2q 18 7 as as RB cord-007796-zggk0x2q 18 8 well well RB cord-007796-zggk0x2q 18 9 as as IN cord-007796-zggk0x2q 18 10 vaccine vaccine NN cord-007796-zggk0x2q 18 11 development development NN cord-007796-zggk0x2q 18 12 . . . cord-007796-zggk0x2q 19 1 Viruses virus NNS cord-007796-zggk0x2q 19 2 are be VBP cord-007796-zggk0x2q 19 3 responsible responsible JJ cord-007796-zggk0x2q 19 4 for for IN cord-007796-zggk0x2q 19 5 the the DT cord-007796-zggk0x2q 19 6 majority majority NN cord-007796-zggk0x2q 19 7 of of IN cord-007796-zggk0x2q 19 8 respiratory respiratory JJ cord-007796-zggk0x2q 19 9 infections infection NNS cord-007796-zggk0x2q 19 10 in in IN cord-007796-zggk0x2q 19 11 childhood childhood NN cord-007796-zggk0x2q 19 12 , , , cord-007796-zggk0x2q 19 13 causing cause VBG cord-007796-zggk0x2q 19 14 considerable considerable JJ cord-007796-zggk0x2q 19 15 morbidity morbidity NN cord-007796-zggk0x2q 19 16 and and CC cord-007796-zggk0x2q 19 17 mortality mortality NN cord-007796-zggk0x2q 19 18 . . . cord-007796-zggk0x2q 20 1 It -PRON- PRP cord-007796-zggk0x2q 20 2 is be VBZ cord-007796-zggk0x2q 20 3 estimated estimate VBN cord-007796-zggk0x2q 20 4 that that IN cord-007796-zggk0x2q 20 5 in in IN cord-007796-zggk0x2q 20 6 the the DT cord-007796-zggk0x2q 20 7 United United NNP cord-007796-zggk0x2q 20 8 States States NNP cord-007796-zggk0x2q 20 9 approximately approximately RB cord-007796-zggk0x2q 20 10 $ $ $ cord-007796-zggk0x2q 20 11 652 652 CD cord-007796-zggk0x2q 20 12 million million CD cord-007796-zggk0x2q 20 13 per per IN cord-007796-zggk0x2q 20 14 year year NN cord-007796-zggk0x2q 20 15 is be VBZ cord-007796-zggk0x2q 20 16 spent spend VBN cord-007796-zggk0x2q 20 17 on on IN cord-007796-zggk0x2q 20 18 medical medical JJ cord-007796-zggk0x2q 20 19 costs cost NNS cord-007796-zggk0x2q 20 20 for for IN cord-007796-zggk0x2q 20 21 respiratory respiratory JJ cord-007796-zggk0x2q 20 22 syncytial syncytial JJ cord-007796-zggk0x2q 20 23 virus virus NN cord-007796-zggk0x2q 20 24 ( ( -LRB- cord-007796-zggk0x2q 20 25 RSV RSV NNP cord-007796-zggk0x2q 20 26 ) ) -RRB- cord-007796-zggk0x2q 20 27 related relate VBN cord-007796-zggk0x2q 20 28 disease disease NN cord-007796-zggk0x2q 20 29 alone alone RB cord-007796-zggk0x2q 21 1 ( ( -LRB- cord-007796-zggk0x2q 21 2 Paramore Paramore NNP cord-007796-zggk0x2q 21 3 et et NNP cord-007796-zggk0x2q 21 4 al al NNP cord-007796-zggk0x2q 21 5 . . NNP cord-007796-zggk0x2q 21 6 , , , cord-007796-zggk0x2q 21 7 2004 2004 CD cord-007796-zggk0x2q 21 8 ) ) -RRB- cord-007796-zggk0x2q 21 9 . . . cord-007796-zggk0x2q 22 1 Viruses virus NNS cord-007796-zggk0x2q 22 2 cause cause VBP cord-007796-zggk0x2q 22 3 a a DT cord-007796-zggk0x2q 22 4 variety variety NN cord-007796-zggk0x2q 22 5 of of IN cord-007796-zggk0x2q 22 6 respiratory respiratory JJ cord-007796-zggk0x2q 22 7 diseases disease NNS cord-007796-zggk0x2q 22 8 in in IN cord-007796-zggk0x2q 22 9 children child NNS cord-007796-zggk0x2q 22 10 from from IN cord-007796-zggk0x2q 22 11 the the DT cord-007796-zggk0x2q 22 12 common common JJ cord-007796-zggk0x2q 22 13 cold cold NN cord-007796-zggk0x2q 22 14 to to IN cord-007796-zggk0x2q 22 15 life life NN cord-007796-zggk0x2q 22 16 - - HYPH cord-007796-zggk0x2q 22 17 threatening threaten VBG cord-007796-zggk0x2q 22 18 pneumonia pneumonia NN cord-007796-zggk0x2q 22 19 and and CC cord-007796-zggk0x2q 22 20 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 22 21 . . . cord-007796-zggk0x2q 23 1 The the DT cord-007796-zggk0x2q 23 2 host host NN cord-007796-zggk0x2q 23 3 reacts react VBZ cord-007796-zggk0x2q 23 4 to to IN cord-007796-zggk0x2q 23 5 a a DT cord-007796-zggk0x2q 23 6 viral viral JJ cord-007796-zggk0x2q 23 7 infection infection NN cord-007796-zggk0x2q 23 8 with with IN cord-007796-zggk0x2q 23 9 a a DT cord-007796-zggk0x2q 23 10 combination combination NN cord-007796-zggk0x2q 23 11 of of IN cord-007796-zggk0x2q 23 12 innate innate JJ cord-007796-zggk0x2q 23 13 and and CC cord-007796-zggk0x2q 23 14 adaptive adaptive JJ cord-007796-zggk0x2q 23 15 immune immune JJ cord-007796-zggk0x2q 23 16 mechanisms mechanism NNS cord-007796-zggk0x2q 23 17 , , , cord-007796-zggk0x2q 23 18 usually usually RB cord-007796-zggk0x2q 23 19 resulting result VBG cord-007796-zggk0x2q 23 20 in in IN cord-007796-zggk0x2q 23 21 the the DT cord-007796-zggk0x2q 23 22 clearance clearance NN cord-007796-zggk0x2q 23 23 of of IN cord-007796-zggk0x2q 23 24 the the DT cord-007796-zggk0x2q 23 25 virus virus NN cord-007796-zggk0x2q 23 26 and and CC cord-007796-zggk0x2q 23 27 clinical clinical JJ cord-007796-zggk0x2q 23 28 recovery recovery NN cord-007796-zggk0x2q 23 29 . . . cord-007796-zggk0x2q 24 1 However however RB cord-007796-zggk0x2q 24 2 , , , cord-007796-zggk0x2q 24 3 there there EX cord-007796-zggk0x2q 24 4 is be VBZ cord-007796-zggk0x2q 24 5 an an DT cord-007796-zggk0x2q 24 6 accumulating accumulate VBG cord-007796-zggk0x2q 24 7 evidence evidence NN cord-007796-zggk0x2q 24 8 for for IN cord-007796-zggk0x2q 24 9 a a DT cord-007796-zggk0x2q 24 10 number number NN cord-007796-zggk0x2q 24 11 of of IN cord-007796-zggk0x2q 24 12 viral viral JJ cord-007796-zggk0x2q 24 13 infections infection NNS cord-007796-zggk0x2q 24 14 that that WDT cord-007796-zggk0x2q 24 15 the the DT cord-007796-zggk0x2q 24 16 host host NN cord-007796-zggk0x2q 24 17 immune immune JJ cord-007796-zggk0x2q 24 18 response response NN cord-007796-zggk0x2q 24 19 actually actually RB cord-007796-zggk0x2q 24 20 enhances enhance VBZ cord-007796-zggk0x2q 24 21 disease disease NN cord-007796-zggk0x2q 24 22 in in IN cord-007796-zggk0x2q 24 23 the the DT cord-007796-zggk0x2q 24 24 course course NN cord-007796-zggk0x2q 24 25 of of IN cord-007796-zggk0x2q 24 26 clearing clear VBG cord-007796-zggk0x2q 24 27 virus virus NN cord-007796-zggk0x2q 24 28 from from IN cord-007796-zggk0x2q 24 29 the the DT cord-007796-zggk0x2q 24 30 infected infected JJ cord-007796-zggk0x2q 24 31 organs organ NNS cord-007796-zggk0x2q 24 32 . . . cord-007796-zggk0x2q 25 1 Interestingly interestingly RB cord-007796-zggk0x2q 25 2 , , , cord-007796-zggk0x2q 25 3 the the DT cord-007796-zggk0x2q 25 4 effectiveness effectiveness NN cord-007796-zggk0x2q 25 5 of of IN cord-007796-zggk0x2q 25 6 the the DT cord-007796-zggk0x2q 25 7 immune immune JJ cord-007796-zggk0x2q 25 8 response response NN cord-007796-zggk0x2q 25 9 seems seem VBZ cord-007796-zggk0x2q 25 10 to to TO cord-007796-zggk0x2q 25 11 be be VB cord-007796-zggk0x2q 25 12 dependent dependent JJ cord-007796-zggk0x2q 25 13 on on IN cord-007796-zggk0x2q 25 14 the the DT cord-007796-zggk0x2q 25 15 age age NN cord-007796-zggk0x2q 25 16 and and CC cord-007796-zggk0x2q 25 17 probably probably RB cord-007796-zggk0x2q 25 18 genetic genetic JJ cord-007796-zggk0x2q 25 19 background background NN cord-007796-zggk0x2q 25 20 of of IN cord-007796-zggk0x2q 25 21 the the DT cord-007796-zggk0x2q 25 22 child child NN cord-007796-zggk0x2q 25 23 . . . cord-007796-zggk0x2q 26 1 This this DT cord-007796-zggk0x2q 26 2 has have VBZ cord-007796-zggk0x2q 26 3 important important JJ cord-007796-zggk0x2q 26 4 implications implication NNS cord-007796-zggk0x2q 26 5 for for IN cord-007796-zggk0x2q 26 6 treatment treatment NN cord-007796-zggk0x2q 26 7 as as RB cord-007796-zggk0x2q 26 8 well well RB cord-007796-zggk0x2q 26 9 as as IN cord-007796-zggk0x2q 26 10 vaccine vaccine NN cord-007796-zggk0x2q 26 11 development development NN cord-007796-zggk0x2q 26 12 . . . cord-007796-zggk0x2q 27 1 Viral viral JJ cord-007796-zggk0x2q 27 2 infections infection NNS cord-007796-zggk0x2q 27 3 play play VBP cord-007796-zggk0x2q 27 4 an an DT cord-007796-zggk0x2q 27 5 important important JJ cord-007796-zggk0x2q 27 6 role role NN cord-007796-zggk0x2q 27 7 in in IN cord-007796-zggk0x2q 27 8 both both CC cord-007796-zggk0x2q 27 9 childhood childhood NN cord-007796-zggk0x2q 27 10 and and CC cord-007796-zggk0x2q 27 11 adult adult NN cord-007796-zggk0x2q 27 12 asthma asthma NN cord-007796-zggk0x2q 27 13 . . . cord-007796-zggk0x2q 28 1 They -PRON- PRP cord-007796-zggk0x2q 28 2 might may MD cord-007796-zggk0x2q 28 3 be be VB cord-007796-zggk0x2q 28 4 instrumental instrumental JJ cord-007796-zggk0x2q 28 5 in in IN cord-007796-zggk0x2q 28 6 the the DT cord-007796-zggk0x2q 28 7 inception inception NN cord-007796-zggk0x2q 28 8 of of IN cord-007796-zggk0x2q 28 9 asthma asthma NN cord-007796-zggk0x2q 28 10 and and CC cord-007796-zggk0x2q 28 11 are be VBP cord-007796-zggk0x2q 28 12 associated associate VBN cord-007796-zggk0x2q 28 13 with with IN cord-007796-zggk0x2q 28 14 the the DT cord-007796-zggk0x2q 28 15 majority majority NN cord-007796-zggk0x2q 28 16 of of IN cord-007796-zggk0x2q 28 17 exacerbations exacerbation NNS cord-007796-zggk0x2q 28 18 in in IN cord-007796-zggk0x2q 28 19 asthmatic asthmatic JJ cord-007796-zggk0x2q 28 20 individuals individual NNS cord-007796-zggk0x2q 28 21 ( ( -LRB- cord-007796-zggk0x2q 29 1 Johnston Johnston NNP cord-007796-zggk0x2q 29 2 et et NNP cord-007796-zggk0x2q 29 3 al al NNP cord-007796-zggk0x2q 29 4 . . . cord-007796-zggk0x2q 30 1 , , , cord-007796-zggk0x2q 30 2 1995 1995 CD cord-007796-zggk0x2q 30 3 ; ; : cord-007796-zggk0x2q 30 4 Bont Bont NNP cord-007796-zggk0x2q 30 5 et et NNP cord-007796-zggk0x2q 30 6 al al NNP cord-007796-zggk0x2q 30 7 . . NNP cord-007796-zggk0x2q 30 8 , , , cord-007796-zggk0x2q 30 9 2000 2000 CD cord-007796-zggk0x2q 30 10 ) ) -RRB- cord-007796-zggk0x2q 30 11 . . . cord-007796-zggk0x2q 31 1 In in IN cord-007796-zggk0x2q 31 2 respect respect NN cord-007796-zggk0x2q 31 3 to to IN cord-007796-zggk0x2q 31 4 the the DT cord-007796-zggk0x2q 31 5 role role NN cord-007796-zggk0x2q 31 6 of of IN cord-007796-zggk0x2q 31 7 viruses virus NNS cord-007796-zggk0x2q 31 8 in in IN cord-007796-zggk0x2q 31 9 the the DT cord-007796-zggk0x2q 31 10 pathogenesis pathogenesis NN cord-007796-zggk0x2q 31 11 of of IN cord-007796-zggk0x2q 31 12 acute acute JJ cord-007796-zggk0x2q 31 13 and and CC cord-007796-zggk0x2q 31 14 chronic chronic JJ cord-007796-zggk0x2q 31 15 airway airway NN cord-007796-zggk0x2q 31 16 disease disease NN cord-007796-zggk0x2q 31 17 in in IN cord-007796-zggk0x2q 31 18 children child NNS cord-007796-zggk0x2q 31 19 , , , cord-007796-zggk0x2q 31 20 it -PRON- PRP cord-007796-zggk0x2q 31 21 is be VBZ cord-007796-zggk0x2q 31 22 of of IN cord-007796-zggk0x2q 31 23 utmost utmost JJ cord-007796-zggk0x2q 31 24 importance importance NN cord-007796-zggk0x2q 31 25 that that WDT cord-007796-zggk0x2q 31 26 we -PRON- PRP cord-007796-zggk0x2q 31 27 gain gain VBP cord-007796-zggk0x2q 31 28 a a DT cord-007796-zggk0x2q 31 29 proper proper JJ cord-007796-zggk0x2q 31 30 understanding understanding NN cord-007796-zggk0x2q 31 31 of of IN cord-007796-zggk0x2q 31 32 the the DT cord-007796-zggk0x2q 31 33 underlying underlie VBG cord-007796-zggk0x2q 31 34 mechanisms mechanism NNS cord-007796-zggk0x2q 31 35 involved involve VBN cord-007796-zggk0x2q 31 36 in in IN cord-007796-zggk0x2q 31 37 order order NN cord-007796-zggk0x2q 31 38 to to TO cord-007796-zggk0x2q 31 39 design design VB cord-007796-zggk0x2q 31 40 effective effective JJ cord-007796-zggk0x2q 31 41 therapeutic therapeutic JJ cord-007796-zggk0x2q 31 42 and and CC cord-007796-zggk0x2q 31 43 preventive preventive JJ cord-007796-zggk0x2q 31 44 strategies strategy NNS cord-007796-zggk0x2q 31 45 . . . cord-007796-zggk0x2q 32 1 Although although IN cord-007796-zggk0x2q 32 2 viral viral JJ cord-007796-zggk0x2q 32 3 respiratory respiratory JJ cord-007796-zggk0x2q 32 4 tract tract NN cord-007796-zggk0x2q 32 5 infections infection NNS cord-007796-zggk0x2q 32 6 are be VBP cord-007796-zggk0x2q 32 7 considered consider VBN cord-007796-zggk0x2q 32 8 to to TO cord-007796-zggk0x2q 32 9 be be VB cord-007796-zggk0x2q 32 10 mainly mainly RB cord-007796-zggk0x2q 32 11 pediatric pediatric JJ cord-007796-zggk0x2q 32 12 diseases disease NNS cord-007796-zggk0x2q 32 13 , , , cord-007796-zggk0x2q 32 14 there there EX cord-007796-zggk0x2q 32 15 is be VBZ cord-007796-zggk0x2q 32 16 an an DT cord-007796-zggk0x2q 32 17 increasing increase VBG cord-007796-zggk0x2q 32 18 acknowledgement acknowledgement NN cord-007796-zggk0x2q 32 19 of of IN cord-007796-zggk0x2q 32 20 their -PRON- PRP$ cord-007796-zggk0x2q 32 21 pathogenic pathogenic JJ cord-007796-zggk0x2q 32 22 potential potential NN cord-007796-zggk0x2q 32 23 in in IN cord-007796-zggk0x2q 32 24 the the DT cord-007796-zggk0x2q 32 25 immunocompromised immunocompromised JJ cord-007796-zggk0x2q 32 26 host host NN cord-007796-zggk0x2q 32 27 of of IN cord-007796-zggk0x2q 32 28 all all DT cord-007796-zggk0x2q 32 29 age age NN cord-007796-zggk0x2q 32 30 groups group NNS cord-007796-zggk0x2q 32 31 and and CC cord-007796-zggk0x2q 32 32 in in IN cord-007796-zggk0x2q 32 33 the the DT cord-007796-zggk0x2q 32 34 elderly elderly JJ cord-007796-zggk0x2q 32 35 . . . cord-007796-zggk0x2q 33 1 causative causative JJ cord-007796-zggk0x2q 33 2 agent agent NN cord-007796-zggk0x2q 33 3 is be VBZ cord-007796-zggk0x2q 33 4 not not RB cord-007796-zggk0x2q 33 5 identified identify VBN cord-007796-zggk0x2q 33 6 . . . cord-007796-zggk0x2q 34 1 When when WRB cord-007796-zggk0x2q 34 2 an an DT cord-007796-zggk0x2q 34 3 upper upper JJ cord-007796-zggk0x2q 34 4 respiratory respiratory JJ cord-007796-zggk0x2q 34 5 tract tract NN cord-007796-zggk0x2q 34 6 infection infection NN cord-007796-zggk0x2q 34 7 in in IN cord-007796-zggk0x2q 34 8 an an DT cord-007796-zggk0x2q 34 9 infant infant NN cord-007796-zggk0x2q 34 10 progresses progress VBZ cord-007796-zggk0x2q 34 11 to to TO cord-007796-zggk0x2q 34 12 lower lower VB cord-007796-zggk0x2q 34 13 respiratory respiratory JJ cord-007796-zggk0x2q 34 14 tract tract NN cord-007796-zggk0x2q 34 15 disease disease NN cord-007796-zggk0x2q 34 16 , , , cord-007796-zggk0x2q 34 17 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 34 18 and and CC cord-007796-zggk0x2q 34 19 pneumonia pneumonia NN cord-007796-zggk0x2q 34 20 are be VBP cord-007796-zggk0x2q 34 21 most most RBS cord-007796-zggk0x2q 34 22 common common JJ cord-007796-zggk0x2q 34 23 . . . cord-007796-zggk0x2q 35 1 Both both DT cord-007796-zggk0x2q 35 2 disease disease NN cord-007796-zggk0x2q 35 3 entities entity NNS cord-007796-zggk0x2q 35 4 are be VBP cord-007796-zggk0x2q 35 5 hard hard JJ cord-007796-zggk0x2q 35 6 to to TO cord-007796-zggk0x2q 35 7 differentiate differentiate VB cord-007796-zggk0x2q 35 8 and and CC cord-007796-zggk0x2q 35 9 no no DT cord-007796-zggk0x2q 35 10 clinically clinically RB cord-007796-zggk0x2q 35 11 relevant relevant JJ cord-007796-zggk0x2q 35 12 differences difference NNS cord-007796-zggk0x2q 35 13 with with IN cord-007796-zggk0x2q 35 14 regard regard NN cord-007796-zggk0x2q 35 15 to to IN cord-007796-zggk0x2q 35 16 outcome outcome NN cord-007796-zggk0x2q 35 17 have have VBP cord-007796-zggk0x2q 35 18 been be VBN cord-007796-zggk0x2q 35 19 identified identify VBN cord-007796-zggk0x2q 35 20 ( ( -LRB- cord-007796-zggk0x2q 35 21 van van NNP cord-007796-zggk0x2q 35 22 Woensel Woensel NNP cord-007796-zggk0x2q 35 23 et et NNP cord-007796-zggk0x2q 35 24 al al NNP cord-007796-zggk0x2q 35 25 . . NNP cord-007796-zggk0x2q 35 26 , , , cord-007796-zggk0x2q 35 27 2003 2003 CD cord-007796-zggk0x2q 35 28 ) ) -RRB- cord-007796-zggk0x2q 35 29 . . . cord-007796-zggk0x2q 36 1 RSV RSV NNP cord-007796-zggk0x2q 36 2 belongs belong VBZ cord-007796-zggk0x2q 36 3 to to IN cord-007796-zggk0x2q 36 4 the the DT cord-007796-zggk0x2q 36 5 paramyxoviridae paramyxoviridae NNP cord-007796-zggk0x2q 36 6 family family NN cord-007796-zggk0x2q 36 7 and and CC cord-007796-zggk0x2q 36 8 the the DT cord-007796-zggk0x2q 36 9 genus genus NN cord-007796-zggk0x2q 36 10 of of IN cord-007796-zggk0x2q 36 11 Pneumovirus Pneumovirus NNP cord-007796-zggk0x2q 36 12 . . . cord-007796-zggk0x2q 37 1 It -PRON- PRP cord-007796-zggk0x2q 37 2 is be VBZ cord-007796-zggk0x2q 37 3 an an DT cord-007796-zggk0x2q 37 4 enveloped envelop VBN cord-007796-zggk0x2q 37 5 unsegmented unsegmente VBN cord-007796-zggk0x2q 37 6 single single RB cord-007796-zggk0x2q 37 7 - - HYPH cord-007796-zggk0x2q 37 8 stranded strand VBN cord-007796-zggk0x2q 37 9 RNA rna NN cord-007796-zggk0x2q 37 10 - - HYPH cord-007796-zggk0x2q 37 11 virus virus NN cord-007796-zggk0x2q 37 12 of of IN cord-007796-zggk0x2q 37 13 which which WDT cord-007796-zggk0x2q 37 14 two two CD cord-007796-zggk0x2q 37 15 subtypes subtype NNS cord-007796-zggk0x2q 37 16 are be VBP cord-007796-zggk0x2q 37 17 known know VBN cord-007796-zggk0x2q 37 18 ( ( -LRB- cord-007796-zggk0x2q 37 19 A a NN cord-007796-zggk0x2q 37 20 and and CC cord-007796-zggk0x2q 37 21 B b NN cord-007796-zggk0x2q 37 22 ) ) -RRB- cord-007796-zggk0x2q 37 23 . . . cord-007796-zggk0x2q 38 1 A a DT cord-007796-zggk0x2q 38 2 clear clear JJ cord-007796-zggk0x2q 38 3 relationship relationship NN cord-007796-zggk0x2q 38 4 between between IN cord-007796-zggk0x2q 38 5 subtype subtype NN cord-007796-zggk0x2q 38 6 and and CC cord-007796-zggk0x2q 38 7 disease disease NN cord-007796-zggk0x2q 38 8 severity severity NN cord-007796-zggk0x2q 38 9 has have VBZ cord-007796-zggk0x2q 38 10 not not RB cord-007796-zggk0x2q 38 11 been be VBN cord-007796-zggk0x2q 38 12 established establish VBN cord-007796-zggk0x2q 38 13 ( ( -LRB- cord-007796-zggk0x2q 38 14 Kneyber Kneyber NNP cord-007796-zggk0x2q 38 15 et et NNP cord-007796-zggk0x2q 38 16 al al NNP cord-007796-zggk0x2q 38 17 . . NNP cord-007796-zggk0x2q 38 18 , , , cord-007796-zggk0x2q 38 19 1996 1996 CD cord-007796-zggk0x2q 38 20 ) ) -RRB- cord-007796-zggk0x2q 38 21 . . . cord-007796-zggk0x2q 39 1 Since since IN cord-007796-zggk0x2q 39 2 RSV RSV NNP cord-007796-zggk0x2q 39 3 infection infection NN cord-007796-zggk0x2q 39 4 does do VBZ cord-007796-zggk0x2q 39 5 not not RB cord-007796-zggk0x2q 39 6 lead lead VB cord-007796-zggk0x2q 39 7 to to TO cord-007796-zggk0x2q 39 8 complete complete VB cord-007796-zggk0x2q 39 9 immunity immunity NN cord-007796-zggk0x2q 39 10 , , , cord-007796-zggk0x2q 39 11 reinfection reinfection NN cord-007796-zggk0x2q 39 12 is be VBZ cord-007796-zggk0x2q 39 13 common common JJ cord-007796-zggk0x2q 39 14 . . . cord-007796-zggk0x2q 40 1 Immaturity immaturity NN cord-007796-zggk0x2q 40 2 of of IN cord-007796-zggk0x2q 40 3 the the DT cord-007796-zggk0x2q 40 4 immune immune JJ cord-007796-zggk0x2q 40 5 system system NN cord-007796-zggk0x2q 40 6 during during IN cord-007796-zggk0x2q 40 7 initial initial JJ cord-007796-zggk0x2q 40 8 infection infection NN cord-007796-zggk0x2q 40 9 seems seem VBZ cord-007796-zggk0x2q 40 10 to to TO cord-007796-zggk0x2q 40 11 be be VB cord-007796-zggk0x2q 40 12 the the DT cord-007796-zggk0x2q 40 13 main main JJ cord-007796-zggk0x2q 40 14 cause cause NN cord-007796-zggk0x2q 40 15 of of IN cord-007796-zggk0x2q 40 16 incomplete incomplete JJ cord-007796-zggk0x2q 40 17 memory memory NN cord-007796-zggk0x2q 40 18 - - HYPH cord-007796-zggk0x2q 40 19 response response NN cord-007796-zggk0x2q 40 20 although although IN cord-007796-zggk0x2q 40 21 an an DT cord-007796-zggk0x2q 40 22 as as RB cord-007796-zggk0x2q 40 23 yet yet RB cord-007796-zggk0x2q 40 24 undefined undefined JJ cord-007796-zggk0x2q 40 25 mechanism mechanism NN cord-007796-zggk0x2q 40 26 of of IN cord-007796-zggk0x2q 40 27 partial partial JJ cord-007796-zggk0x2q 40 28 immune immune JJ cord-007796-zggk0x2q 40 29 evasion evasion NN cord-007796-zggk0x2q 40 30 by by IN cord-007796-zggk0x2q 40 31 RSV RSV NNP cord-007796-zggk0x2q 40 32 can can MD cord-007796-zggk0x2q 40 33 not not RB cord-007796-zggk0x2q 40 34 be be VB cord-007796-zggk0x2q 40 35 ruled rule VBN cord-007796-zggk0x2q 40 36 out out RP cord-007796-zggk0x2q 40 37 . . . cord-007796-zggk0x2q 41 1 Recently recently RB cord-007796-zggk0x2q 41 2 , , , cord-007796-zggk0x2q 41 3 it -PRON- PRP cord-007796-zggk0x2q 41 4 was be VBD cord-007796-zggk0x2q 41 5 suggested suggest VBN cord-007796-zggk0x2q 41 6 that that IN cord-007796-zggk0x2q 41 7 RSV RSV NNP cord-007796-zggk0x2q 41 8 could could MD cord-007796-zggk0x2q 41 9 cause cause VB cord-007796-zggk0x2q 41 10 persistent persistent JJ cord-007796-zggk0x2q 41 11 infection infection NN cord-007796-zggk0x2q 41 12 or or CC cord-007796-zggk0x2q 41 13 latency latency NN cord-007796-zggk0x2q 42 1 ( ( -LRB- cord-007796-zggk0x2q 42 2 Dakhama Dakhama NNP cord-007796-zggk0x2q 42 3 et et FW cord-007796-zggk0x2q 42 4 al al NNP cord-007796-zggk0x2q 42 5 . . NNP cord-007796-zggk0x2q 42 6 , , , cord-007796-zggk0x2q 42 7 1997 1997 CD cord-007796-zggk0x2q 42 8 ; ; : cord-007796-zggk0x2q 42 9 Schwarze Schwarze NNP cord-007796-zggk0x2q 42 10 et et NNP cord-007796-zggk0x2q 42 11 al al NNP cord-007796-zggk0x2q 42 12 . . NNP cord-007796-zggk0x2q 42 13 , , , cord-007796-zggk0x2q 42 14 2004 2004 CD cord-007796-zggk0x2q 42 15 ) ) -RRB- cord-007796-zggk0x2q 42 16 , , , cord-007796-zggk0x2q 42 17 although although IN cord-007796-zggk0x2q 42 18 the the DT cord-007796-zggk0x2q 42 19 significance significance NN cord-007796-zggk0x2q 42 20 of of IN cord-007796-zggk0x2q 42 21 this this DT cord-007796-zggk0x2q 42 22 is be VBZ cord-007796-zggk0x2q 42 23 not not RB cord-007796-zggk0x2q 42 24 clear clear JJ cord-007796-zggk0x2q 42 25 . . . cord-007796-zggk0x2q 43 1 RSV RSV NNP cord-007796-zggk0x2q 43 2 affects affect VBZ cord-007796-zggk0x2q 43 3 70 70 CD cord-007796-zggk0x2q 43 4 % % NN cord-007796-zggk0x2q 43 5 of of IN cord-007796-zggk0x2q 43 6 infants infant NNS cord-007796-zggk0x2q 43 7 in in IN cord-007796-zggk0x2q 43 8 the the DT cord-007796-zggk0x2q 43 9 first first JJ cord-007796-zggk0x2q 43 10 year year NN cord-007796-zggk0x2q 43 11 of of IN cord-007796-zggk0x2q 43 12 life life NN cord-007796-zggk0x2q 43 13 , , , cord-007796-zggk0x2q 43 14 and and CC cord-007796-zggk0x2q 43 15 by by IN cord-007796-zggk0x2q 43 16 the the DT cord-007796-zggk0x2q 43 17 age age NN cord-007796-zggk0x2q 43 18 of of IN cord-007796-zggk0x2q 43 19 two two CD cord-007796-zggk0x2q 43 20 nearly nearly RB cord-007796-zggk0x2q 43 21 all all DT cord-007796-zggk0x2q 43 22 children child NNS cord-007796-zggk0x2q 43 23 have have VBP cord-007796-zggk0x2q 43 24 been be VBN cord-007796-zggk0x2q 43 25 infected infect VBN cord-007796-zggk0x2q 43 26 . . . cord-007796-zggk0x2q 44 1 ( ( -LRB- cord-007796-zggk0x2q 44 2 Figure figure NN cord-007796-zggk0x2q 44 3 4 4 CD cord-007796-zggk0x2q 44 4 .1 .1 CD cord-007796-zggk0x2q 44 5 ) ) -RRB- cord-007796-zggk0x2q 45 1 It -PRON- PRP cord-007796-zggk0x2q 45 2 is be VBZ cord-007796-zggk0x2q 45 3 likely likely JJ cord-007796-zggk0x2q 45 4 that that IN cord-007796-zggk0x2q 45 5 a a DT cord-007796-zggk0x2q 45 6 specific specific JJ cord-007796-zggk0x2q 45 7 balance balance NN cord-007796-zggk0x2q 45 8 and and CC cord-007796-zggk0x2q 45 9 timeframe timeframe NN cord-007796-zggk0x2q 45 10 of of IN cord-007796-zggk0x2q 45 11 changes change NNS cord-007796-zggk0x2q 45 12 in in IN cord-007796-zggk0x2q 45 13 air air NN cord-007796-zggk0x2q 45 14 temperature temperature NN cord-007796-zggk0x2q 45 15 and and CC cord-007796-zggk0x2q 45 16 humidity humidity NN cord-007796-zggk0x2q 45 17 are be VBP cord-007796-zggk0x2q 45 18 responsible responsible JJ cord-007796-zggk0x2q 45 19 for for IN cord-007796-zggk0x2q 45 20 the the DT cord-007796-zggk0x2q 45 21 well well RB cord-007796-zggk0x2q 45 22 - - HYPH cord-007796-zggk0x2q 45 23 defined define VBN cord-007796-zggk0x2q 45 24 yearly yearly JJ cord-007796-zggk0x2q 45 25 winter winter NN cord-007796-zggk0x2q 45 26 outbreaks outbreak NNS cord-007796-zggk0x2q 45 27 of of IN cord-007796-zggk0x2q 45 28 RSV RSV NNP cord-007796-zggk0x2q 46 1 ( ( -LRB- cord-007796-zggk0x2q 46 2 Stensballe Stensballe NNP cord-007796-zggk0x2q 46 3 et et FW cord-007796-zggk0x2q 46 4 al al NNP cord-007796-zggk0x2q 46 5 . . NNP cord-007796-zggk0x2q 46 6 , , , cord-007796-zggk0x2q 46 7 2003 2003 CD cord-007796-zggk0x2q 46 8 ) ) -RRB- cord-007796-zggk0x2q 46 9 . . . cord-007796-zggk0x2q 47 1 In in IN cord-007796-zggk0x2q 47 2 most most JJS cord-007796-zggk0x2q 47 3 infants infant NNS cord-007796-zggk0x2q 47 4 as as RB cord-007796-zggk0x2q 47 5 well well RB cord-007796-zggk0x2q 47 6 as as IN cord-007796-zggk0x2q 47 7 in in IN cord-007796-zggk0x2q 47 8 older old JJR cord-007796-zggk0x2q 47 9 children child NNS cord-007796-zggk0x2q 47 10 and and CC cord-007796-zggk0x2q 47 11 adults adult NNS cord-007796-zggk0x2q 47 12 , , , cord-007796-zggk0x2q 47 13 RSV RSV NNP cord-007796-zggk0x2q 47 14 is be VBZ cord-007796-zggk0x2q 47 15 the the DT cord-007796-zggk0x2q 47 16 cause cause NN cord-007796-zggk0x2q 47 17 of of IN cord-007796-zggk0x2q 47 18 upper upper JJ cord-007796-zggk0x2q 47 19 respiratory respiratory JJ cord-007796-zggk0x2q 47 20 tract tract NN cord-007796-zggk0x2q 47 21 infection infection NN cord-007796-zggk0x2q 47 22 with with IN cord-007796-zggk0x2q 47 23 mild mild JJ cord-007796-zggk0x2q 47 24 symptoms symptom NNS cord-007796-zggk0x2q 47 25 . . . cord-007796-zggk0x2q 48 1 However however RB cord-007796-zggk0x2q 48 2 , , , cord-007796-zggk0x2q 48 3 in in IN cord-007796-zggk0x2q 48 4 the the DT cord-007796-zggk0x2q 48 5 very very RB cord-007796-zggk0x2q 48 6 young young JJ cord-007796-zggk0x2q 48 7 , , , cord-007796-zggk0x2q 48 8 the the DT cord-007796-zggk0x2q 48 9 infection infection NN cord-007796-zggk0x2q 48 10 spreads spread VBZ cord-007796-zggk0x2q 48 11 to to IN cord-007796-zggk0x2q 48 12 the the DT cord-007796-zggk0x2q 48 13 lower low JJR cord-007796-zggk0x2q 48 14 respiratory respiratory JJ cord-007796-zggk0x2q 48 15 tract tract NN cord-007796-zggk0x2q 48 16 in in IN cord-007796-zggk0x2q 48 17 approximately approximately RB cord-007796-zggk0x2q 48 18 40 40 CD cord-007796-zggk0x2q 48 19 % % NN cord-007796-zggk0x2q 48 20 of of IN cord-007796-zggk0x2q 48 21 cases case NNS cord-007796-zggk0x2q 48 22 . . . cord-007796-zggk0x2q 49 1 One one CD cord-007796-zggk0x2q 49 2 to to TO cord-007796-zggk0x2q 49 3 three three CD cord-007796-zggk0x2q 49 4 percent percent NN cord-007796-zggk0x2q 49 5 of of IN cord-007796-zggk0x2q 49 6 infants infant NNS cord-007796-zggk0x2q 49 7 develop develop VBP cord-007796-zggk0x2q 49 8 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 49 9 or or CC cord-007796-zggk0x2q 49 10 pneumonia pneumonia NN cord-007796-zggk0x2q 49 11 requiring require VBG cord-007796-zggk0x2q 49 12 hospitalization hospitalization NN cord-007796-zggk0x2q 49 13 , , , cord-007796-zggk0x2q 49 14 with with IN cord-007796-zggk0x2q 49 15 a a DT cord-007796-zggk0x2q 49 16 considerable considerable JJ cord-007796-zggk0x2q 49 17 number number NN cord-007796-zggk0x2q 49 18 requiring require VBG cord-007796-zggk0x2q 49 19 mechanical mechanical JJ cord-007796-zggk0x2q 49 20 ventilatory ventilatory JJ cord-007796-zggk0x2q 49 21 support support NN cord-007796-zggk0x2q 49 22 . . . cord-007796-zggk0x2q 50 1 Apart apart RB cord-007796-zggk0x2q 50 2 from from IN cord-007796-zggk0x2q 50 3 the the DT cord-007796-zggk0x2q 50 4 obvious obvious JJ cord-007796-zggk0x2q 50 5 respiratory respiratory JJ cord-007796-zggk0x2q 50 6 symptoms symptom NNS cord-007796-zggk0x2q 50 7 , , , cord-007796-zggk0x2q 50 8 very very RB cord-007796-zggk0x2q 50 9 young young JJ cord-007796-zggk0x2q 50 10 children child NNS cord-007796-zggk0x2q 50 11 frequently frequently RB cord-007796-zggk0x2q 50 12 present present JJ cord-007796-zggk0x2q 50 13 with with IN cord-007796-zggk0x2q 50 14 atypical atypical JJ cord-007796-zggk0x2q 50 15 symptoms symptom NNS cord-007796-zggk0x2q 50 16 such such JJ cord-007796-zggk0x2q 50 17 as as IN cord-007796-zggk0x2q 50 18 impaired impair VBN cord-007796-zggk0x2q 50 19 feeding feeding NN cord-007796-zggk0x2q 50 20 , , , cord-007796-zggk0x2q 50 21 vomiting vomiting NN cord-007796-zggk0x2q 50 22 , , , cord-007796-zggk0x2q 50 23 lethargy lethargy NN cord-007796-zggk0x2q 50 24 , , , cord-007796-zggk0x2q 50 25 and and CC cord-007796-zggk0x2q 50 26 apnea apnea NN cord-007796-zggk0x2q 50 27 ( ( -LRB- cord-007796-zggk0x2q 50 28 Kneyber Kneyber NNP cord-007796-zggk0x2q 50 29 et et NNP cord-007796-zggk0x2q 50 30 al al NNP cord-007796-zggk0x2q 50 31 . . NNP cord-007796-zggk0x2q 50 32 , , , cord-007796-zggk0x2q 50 33 1998 1998 CD cord-007796-zggk0x2q 50 34 ) ) -RRB- cord-007796-zggk0x2q 50 35 . . . cord-007796-zggk0x2q 51 1 Several several JJ cord-007796-zggk0x2q 51 2 risk risk NN cord-007796-zggk0x2q 51 3 factors factor NNS cord-007796-zggk0x2q 51 4 for for IN cord-007796-zggk0x2q 51 5 more more RBR cord-007796-zggk0x2q 51 6 severe severe JJ cord-007796-zggk0x2q 51 7 disease disease NN cord-007796-zggk0x2q 51 8 have have VBP cord-007796-zggk0x2q 51 9 been be VBN cord-007796-zggk0x2q 51 10 identified identify VBN cord-007796-zggk0x2q 51 11 , , , cord-007796-zggk0x2q 51 12 including include VBG cord-007796-zggk0x2q 51 13 age age NN cord-007796-zggk0x2q 51 14 less less JJR cord-007796-zggk0x2q 51 15 than than IN cord-007796-zggk0x2q 51 16 6 6 CD cord-007796-zggk0x2q 51 17 weeks week NNS cord-007796-zggk0x2q 51 18 , , , cord-007796-zggk0x2q 51 19 prematurity prematurity NN cord-007796-zggk0x2q 51 20 , , , cord-007796-zggk0x2q 51 21 pre pre JJ cord-007796-zggk0x2q 51 22 - - JJ cord-007796-zggk0x2q 51 23 existent existent JJ cord-007796-zggk0x2q 51 24 cardiorespiratory cardiorespiratory JJ cord-007796-zggk0x2q 51 25 disease disease NN cord-007796-zggk0x2q 51 26 and and CC cord-007796-zggk0x2q 51 27 immunological immunological JJ cord-007796-zggk0x2q 51 28 impairment impairment NN cord-007796-zggk0x2q 51 29 ( ( -LRB- cord-007796-zggk0x2q 51 30 Bont Bont NNP cord-007796-zggk0x2q 51 31 and and CC cord-007796-zggk0x2q 51 32 Kimpen Kimpen NNP cord-007796-zggk0x2q 51 33 , , , cord-007796-zggk0x2q 51 34 2002 2002 CD cord-007796-zggk0x2q 51 35 ) ) -RRB- cord-007796-zggk0x2q 51 36 . . . cord-007796-zggk0x2q 52 1 Respiratory respiratory JJ cord-007796-zggk0x2q 52 2 symptoms symptom NNS cord-007796-zggk0x2q 52 3 are be VBP cord-007796-zggk0x2q 52 4 directly directly RB cord-007796-zggk0x2q 52 5 related relate VBN cord-007796-zggk0x2q 52 6 to to IN cord-007796-zggk0x2q 52 7 airway airway NN cord-007796-zggk0x2q 52 8 pathology pathology NN cord-007796-zggk0x2q 52 9 . . . cord-007796-zggk0x2q 53 1 Necrosis necrosis NN cord-007796-zggk0x2q 53 2 of of IN cord-007796-zggk0x2q 53 3 the the DT cord-007796-zggk0x2q 53 4 airway airway NN cord-007796-zggk0x2q 53 5 epithelium epithelium NN cord-007796-zggk0x2q 53 6 is be VBZ cord-007796-zggk0x2q 53 7 a a DT cord-007796-zggk0x2q 53 8 key key JJ cord-007796-zggk0x2q 53 9 phenomenon phenomenon NN cord-007796-zggk0x2q 53 10 resulting result VBG cord-007796-zggk0x2q 53 11 in in IN cord-007796-zggk0x2q 53 12 sloughing sloughing NN cord-007796-zggk0x2q 53 13 of of IN cord-007796-zggk0x2q 53 14 the the DT cord-007796-zggk0x2q 53 15 epithelial epithelial JJ cord-007796-zggk0x2q 53 16 cells cell NNS cord-007796-zggk0x2q 53 17 . . . cord-007796-zggk0x2q 54 1 Together together RB cord-007796-zggk0x2q 54 2 with with IN cord-007796-zggk0x2q 54 3 a a DT cord-007796-zggk0x2q 54 4 dramatic dramatic JJ cord-007796-zggk0x2q 54 5 influx influx NN cord-007796-zggk0x2q 54 6 of of IN cord-007796-zggk0x2q 54 7 inflammatory inflammatory JJ cord-007796-zggk0x2q 54 8 cells cell NNS cord-007796-zggk0x2q 54 9 into into IN cord-007796-zggk0x2q 54 10 the the DT cord-007796-zggk0x2q 54 11 airways airway NNS cord-007796-zggk0x2q 54 12 and and CC cord-007796-zggk0x2q 54 13 increased increase VBN cord-007796-zggk0x2q 54 14 mucus mucus NN cord-007796-zggk0x2q 54 15 production production NN cord-007796-zggk0x2q 54 16 , , , cord-007796-zggk0x2q 54 17 this this DT cord-007796-zggk0x2q 54 18 leads lead VBZ cord-007796-zggk0x2q 54 19 to to IN cord-007796-zggk0x2q 54 20 the the DT cord-007796-zggk0x2q 54 21 formation formation NN cord-007796-zggk0x2q 54 22 of of IN cord-007796-zggk0x2q 54 23 copious copious JJ cord-007796-zggk0x2q 54 24 secretions secretion NNS cord-007796-zggk0x2q 54 25 that that WDT cord-007796-zggk0x2q 54 26 block block VBP cord-007796-zggk0x2q 54 27 the the DT cord-007796-zggk0x2q 54 28 small small JJ cord-007796-zggk0x2q 54 29 airways airway NNS cord-007796-zggk0x2q 54 30 . . . cord-007796-zggk0x2q 55 1 Mucosal Mucosal NNP cord-007796-zggk0x2q 55 2 edema edema NN cord-007796-zggk0x2q 55 3 and and CC cord-007796-zggk0x2q 55 4 bronchospasm bronchospasm JJ cord-007796-zggk0x2q 55 5 through through IN cord-007796-zggk0x2q 55 6 irritation irritation NN cord-007796-zggk0x2q 55 7 of of IN cord-007796-zggk0x2q 55 8 subepithelial subepithelial JJ cord-007796-zggk0x2q 55 9 nerve nerve NN cord-007796-zggk0x2q 55 10 endings ending NNS cord-007796-zggk0x2q 55 11 further further JJ cord-007796-zggk0x2q 55 12 compromise compromise NN cord-007796-zggk0x2q 55 13 airway airway NN cord-007796-zggk0x2q 55 14 diameter diameter NN cord-007796-zggk0x2q 55 15 . . . cord-007796-zggk0x2q 56 1 Although although IN cord-007796-zggk0x2q 56 2 antibiotics antibiotic NNS cord-007796-zggk0x2q 56 3 are be VBP cord-007796-zggk0x2q 56 4 prescribed prescribe VBN cord-007796-zggk0x2q 56 5 for for IN cord-007796-zggk0x2q 56 6 up up IN cord-007796-zggk0x2q 56 7 to to TO cord-007796-zggk0x2q 56 8 50 50 CD cord-007796-zggk0x2q 56 9 % % NN cord-007796-zggk0x2q 56 10 of of IN cord-007796-zggk0x2q 56 11 children child NNS cord-007796-zggk0x2q 56 12 with with IN cord-007796-zggk0x2q 56 13 lower low JJR cord-007796-zggk0x2q 56 14 respiratory respiratory JJ cord-007796-zggk0x2q 56 15 tract tract NN cord-007796-zggk0x2q 56 16 infections infection NNS cord-007796-zggk0x2q 56 17 , , , cord-007796-zggk0x2q 56 18 proof proof NN cord-007796-zggk0x2q 56 19 of of IN cord-007796-zggk0x2q 56 20 bacterial bacterial JJ cord-007796-zggk0x2q 56 21 superinfection superinfection NN cord-007796-zggk0x2q 56 22 is be VBZ cord-007796-zggk0x2q 56 23 only only RB cord-007796-zggk0x2q 56 24 found find VBN cord-007796-zggk0x2q 56 25 in in IN cord-007796-zggk0x2q 56 26 a a DT cord-007796-zggk0x2q 56 27 minority minority NN cord-007796-zggk0x2q 56 28 of of IN cord-007796-zggk0x2q 56 29 patients patient NNS cord-007796-zggk0x2q 56 30 and and CC cord-007796-zggk0x2q 56 31 the the DT cord-007796-zggk0x2q 56 32 role role NN cord-007796-zggk0x2q 56 33 of of IN cord-007796-zggk0x2q 56 34 this this DT cord-007796-zggk0x2q 56 35 event event NN cord-007796-zggk0x2q 56 36 in in IN cord-007796-zggk0x2q 56 37 the the DT cord-007796-zggk0x2q 56 38 pathogenesis pathogenesis NN cord-007796-zggk0x2q 56 39 of of IN cord-007796-zggk0x2q 56 40 severe severe JJ cord-007796-zggk0x2q 56 41 disease disease NN cord-007796-zggk0x2q 56 42 remains remain VBZ cord-007796-zggk0x2q 56 43 controversial controversial JJ cord-007796-zggk0x2q 57 1 ( ( -LRB- cord-007796-zggk0x2q 57 2 Purcell Purcell NNP cord-007796-zggk0x2q 57 3 and and CC cord-007796-zggk0x2q 57 4 Fergie Fergie NNP cord-007796-zggk0x2q 57 5 , , , cord-007796-zggk0x2q 57 6 2002 2002 CD cord-007796-zggk0x2q 57 7 ; ; : cord-007796-zggk0x2q 57 8 Bloomfield Bloomfield NNP cord-007796-zggk0x2q 57 9 et et NNP cord-007796-zggk0x2q 57 10 al al NNP cord-007796-zggk0x2q 57 11 . . NNP cord-007796-zggk0x2q 57 12 , , , cord-007796-zggk0x2q 57 13 2004 2004 CD cord-007796-zggk0x2q 57 14 ) ) -RRB- cord-007796-zggk0x2q 57 15 . . . cord-007796-zggk0x2q 58 1 On on IN cord-007796-zggk0x2q 58 2 the the DT cord-007796-zggk0x2q 58 3 other other JJ cord-007796-zggk0x2q 58 4 hand hand NN cord-007796-zggk0x2q 58 5 , , , cord-007796-zggk0x2q 58 6 it -PRON- PRP cord-007796-zggk0x2q 58 7 has have VBZ cord-007796-zggk0x2q 58 8 been be VBN cord-007796-zggk0x2q 58 9 demonstrated demonstrate VBN cord-007796-zggk0x2q 58 10 that that IN cord-007796-zggk0x2q 58 11 RSV RSV NNP cord-007796-zggk0x2q 58 12 infection infection NN cord-007796-zggk0x2q 58 13 of of IN cord-007796-zggk0x2q 58 14 airway airway JJ cord-007796-zggk0x2q 58 15 epithelial epithelial JJ cord-007796-zggk0x2q 58 16 cells cell NNS cord-007796-zggk0x2q 58 17 in in IN cord-007796-zggk0x2q 58 18 vitro vitro FW cord-007796-zggk0x2q 58 19 enhances enhance VBZ cord-007796-zggk0x2q 58 20 adherence adherence NN cord-007796-zggk0x2q 58 21 of of IN cord-007796-zggk0x2q 58 22 S. S. NNP cord-007796-zggk0x2q 58 23 pneumoniae pneumoniae NN cord-007796-zggk0x2q 58 24 ( ( -LRB- cord-007796-zggk0x2q 58 25 Hament Hament NNP cord-007796-zggk0x2q 58 26 et et NNP cord-007796-zggk0x2q 58 27 al al NNP cord-007796-zggk0x2q 58 28 . . NNP cord-007796-zggk0x2q 58 29 , , , cord-007796-zggk0x2q 58 30 2004 2004 CD cord-007796-zggk0x2q 58 31 ) ) -RRB- cord-007796-zggk0x2q 58 32 . . . cord-007796-zggk0x2q 59 1 The the DT cord-007796-zggk0x2q 59 2 influenza influenza NN cord-007796-zggk0x2q 59 3 virus virus NN cord-007796-zggk0x2q 59 4 belongs belong VBZ cord-007796-zggk0x2q 59 5 to to IN cord-007796-zggk0x2q 59 6 the the DT cord-007796-zggk0x2q 59 7 orthomyxoviridae orthomyxoviridae NNP cord-007796-zggk0x2q 59 8 family family NN cord-007796-zggk0x2q 59 9 and and CC cord-007796-zggk0x2q 59 10 is be VBZ cord-007796-zggk0x2q 59 11 an an DT cord-007796-zggk0x2q 59 12 enveloped envelop VBN cord-007796-zggk0x2q 59 13 segmented segmented JJ cord-007796-zggk0x2q 59 14 single single RB cord-007796-zggk0x2q 59 15 - - HYPH cord-007796-zggk0x2q 59 16 stranded strand VBN cord-007796-zggk0x2q 59 17 RNA RNA NNP cord-007796-zggk0x2q 59 18 ( ( -LRB- cord-007796-zggk0x2q 59 19 ssRNA ssrna NN cord-007796-zggk0x2q 59 20 ) ) -RRB- cord-007796-zggk0x2q 59 21 virus virus NN cord-007796-zggk0x2q 59 22 ( ( -LRB- cord-007796-zggk0x2q 59 23 Table table NN cord-007796-zggk0x2q 59 24 4 4 CD cord-007796-zggk0x2q 59 25 .1 .1 CD cord-007796-zggk0x2q 59 26 ) ) -RRB- cord-007796-zggk0x2q 59 27 . . . cord-007796-zggk0x2q 60 1 The the DT cord-007796-zggk0x2q 60 2 structural structural JJ cord-007796-zggk0x2q 60 3 proteins protein NNS cord-007796-zggk0x2q 60 4 of of IN cord-007796-zggk0x2q 60 5 the the DT cord-007796-zggk0x2q 60 6 virion virion NN cord-007796-zggk0x2q 60 7 are be VBP cord-007796-zggk0x2q 60 8 encoded encode VBN cord-007796-zggk0x2q 60 9 by by IN cord-007796-zggk0x2q 60 10 separate separate JJ cord-007796-zggk0x2q 60 11 gene gene NN cord-007796-zggk0x2q 60 12 segments segment NNS cord-007796-zggk0x2q 60 13 and and CC cord-007796-zggk0x2q 60 14 include include VBP cord-007796-zggk0x2q 60 15 three three CD cord-007796-zggk0x2q 60 16 viral viral JJ cord-007796-zggk0x2q 60 17 RNA RNA NNP cord-007796-zggk0x2q 60 18 polymerases polymerase NNS cord-007796-zggk0x2q 60 19 , , , cord-007796-zggk0x2q 60 20 nucleoprotein nucleoprotein NNP cord-007796-zggk0x2q 60 21 , , , cord-007796-zggk0x2q 60 22 matrix matrix NN cord-007796-zggk0x2q 60 23 , , , cord-007796-zggk0x2q 60 24 and and CC cord-007796-zggk0x2q 60 25 the the DT cord-007796-zggk0x2q 60 26 hemagglutinin hemagglutinin NN cord-007796-zggk0x2q 60 27 ( ( -LRB- cord-007796-zggk0x2q 60 28 HA HA NNP cord-007796-zggk0x2q 60 29 ) ) -RRB- cord-007796-zggk0x2q 60 30 and and CC cord-007796-zggk0x2q 60 31 neuraminidase neuraminidase NN cord-007796-zggk0x2q 60 32 ( ( -LRB- cord-007796-zggk0x2q 60 33 NA NA NNP cord-007796-zggk0x2q 60 34 ) ) -RRB- cord-007796-zggk0x2q 60 35 surface surface NN cord-007796-zggk0x2q 60 36 glycoproteins glycoprotein NNS cord-007796-zggk0x2q 60 37 . . . cord-007796-zggk0x2q 61 1 On on IN cord-007796-zggk0x2q 61 2 the the DT cord-007796-zggk0x2q 61 3 basis basis NN cord-007796-zggk0x2q 61 4 of of IN cord-007796-zggk0x2q 61 5 their -PRON- PRP$ cord-007796-zggk0x2q 61 6 nucleocapsid nucleocapsid NN cord-007796-zggk0x2q 61 7 and and CC cord-007796-zggk0x2q 61 8 matrix matrix NN cord-007796-zggk0x2q 61 9 protein protein NN cord-007796-zggk0x2q 61 10 antigens antigen NNS cord-007796-zggk0x2q 61 11 , , , cord-007796-zggk0x2q 61 12 the the DT cord-007796-zggk0x2q 61 13 influenza influenza NN cord-007796-zggk0x2q 61 14 viruses virus NNS cord-007796-zggk0x2q 61 15 are be VBP cord-007796-zggk0x2q 61 16 divided divide VBN cord-007796-zggk0x2q 61 17 into into IN cord-007796-zggk0x2q 61 18 three three CD cord-007796-zggk0x2q 61 19 distinct distinct JJ cord-007796-zggk0x2q 61 20 immunological immunological JJ cord-007796-zggk0x2q 61 21 types type NNS cord-007796-zggk0x2q 61 22 ( ( -LRB- cord-007796-zggk0x2q 61 23 A A NNP cord-007796-zggk0x2q 61 24 , , , cord-007796-zggk0x2q 61 25 B b NN cord-007796-zggk0x2q 61 26 , , , cord-007796-zggk0x2q 61 27 and and CC cord-007796-zggk0x2q 61 28 C C NNP cord-007796-zggk0x2q 61 29 ) ) -RRB- cord-007796-zggk0x2q 61 30 . . . cord-007796-zggk0x2q 62 1 Although although IN cord-007796-zggk0x2q 62 2 all all DT cord-007796-zggk0x2q 62 3 three three CD cord-007796-zggk0x2q 62 4 influenza influenza NN cord-007796-zggk0x2q 62 5 viruses virus NNS cord-007796-zggk0x2q 62 6 cause cause VBP cord-007796-zggk0x2q 62 7 respiratory respiratory JJ cord-007796-zggk0x2q 62 8 disease disease NN cord-007796-zggk0x2q 62 9 in in IN cord-007796-zggk0x2q 62 10 humans human NNS cord-007796-zggk0x2q 62 11 , , , cord-007796-zggk0x2q 62 12 only only RB cord-007796-zggk0x2q 62 13 A a NN cord-007796-zggk0x2q 62 14 and and CC cord-007796-zggk0x2q 62 15 B b NN cord-007796-zggk0x2q 62 16 are be VBP cord-007796-zggk0x2q 62 17 known know VBN cord-007796-zggk0x2q 62 18 to to TO cord-007796-zggk0x2q 62 19 cause cause VB cord-007796-zggk0x2q 62 20 epidemics epidemic NNS cord-007796-zggk0x2q 62 21 . . . cord-007796-zggk0x2q 63 1 Induction induction NN cord-007796-zggk0x2q 63 2 of of IN cord-007796-zggk0x2q 63 3 a a DT cord-007796-zggk0x2q 63 4 memory memory NN cord-007796-zggk0x2q 63 5 - - HYPH cord-007796-zggk0x2q 63 6 response response NN cord-007796-zggk0x2q 63 7 results result NNS cord-007796-zggk0x2q 63 8 in in IN cord-007796-zggk0x2q 63 9 long long RB cord-007796-zggk0x2q 63 10 - - HYPH cord-007796-zggk0x2q 63 11 lasting last VBG cord-007796-zggk0x2q 63 12 immunity immunity NN cord-007796-zggk0x2q 63 13 and and CC cord-007796-zggk0x2q 64 1 it -PRON- PRP cord-007796-zggk0x2q 64 2 is be VBZ cord-007796-zggk0x2q 64 3 the the DT cord-007796-zggk0x2q 64 4 antigenic antigenic JJ cord-007796-zggk0x2q 64 5 variation variation NN cord-007796-zggk0x2q 64 6 that that WDT cord-007796-zggk0x2q 64 7 is be VBZ cord-007796-zggk0x2q 64 8 responsible responsible JJ cord-007796-zggk0x2q 64 9 for for IN cord-007796-zggk0x2q 64 10 frequent frequent JJ cord-007796-zggk0x2q 64 11 reinfection reinfection NN cord-007796-zggk0x2q 64 12 with with IN cord-007796-zggk0x2q 64 13 the the DT cord-007796-zggk0x2q 64 14 virus virus NN cord-007796-zggk0x2q 64 15 . . . cord-007796-zggk0x2q 65 1 The the DT cord-007796-zggk0x2q 65 2 most most RBS cord-007796-zggk0x2q 65 3 antigenic antigenic JJ cord-007796-zggk0x2q 65 4 variation variation NN cord-007796-zggk0x2q 65 5 is be VBZ cord-007796-zggk0x2q 65 6 seen see VBN cord-007796-zggk0x2q 65 7 in in IN cord-007796-zggk0x2q 65 8 the the DT cord-007796-zggk0x2q 65 9 virus virus NN cord-007796-zggk0x2q 65 10 that that WDT cord-007796-zggk0x2q 65 11 infects infect VBZ cord-007796-zggk0x2q 65 12 both both DT cord-007796-zggk0x2q 65 13 animals animal NNS cord-007796-zggk0x2q 65 14 and and CC cord-007796-zggk0x2q 65 15 humans human NNS cord-007796-zggk0x2q 65 16 , , , cord-007796-zggk0x2q 65 17 influenza influenza NN cord-007796-zggk0x2q 65 18 A. a. NN cord-007796-zggk0x2q 65 19 Fourteen fourteen CD cord-007796-zggk0x2q 65 20 subtypes subtype NNS cord-007796-zggk0x2q 65 21 of of IN cord-007796-zggk0x2q 65 22 hemagglutinin hemagglutinin NN cord-007796-zggk0x2q 65 23 ( ( -LRB- cord-007796-zggk0x2q 65 24 H1-H14 H1-H14 NNP cord-007796-zggk0x2q 65 25 ) ) -RRB- cord-007796-zggk0x2q 65 26 and and CC cord-007796-zggk0x2q 65 27 nine nine CD cord-007796-zggk0x2q 65 28 types type NNS cord-007796-zggk0x2q 65 29 of of IN cord-007796-zggk0x2q 65 30 neuraminidase neuraminidase NN cord-007796-zggk0x2q 65 31 ( ( -LRB- cord-007796-zggk0x2q 65 32 N1-N9 N1-N9 NNP cord-007796-zggk0x2q 65 33 ) ) -RRB- cord-007796-zggk0x2q 65 34 are be VBP cord-007796-zggk0x2q 65 35 circulating circulate VBG cord-007796-zggk0x2q 65 36 in in IN cord-007796-zggk0x2q 65 37 nature nature NN cord-007796-zggk0x2q 65 38 . . . cord-007796-zggk0x2q 66 1 The the DT cord-007796-zggk0x2q 66 2 segmentation segmentation NN cord-007796-zggk0x2q 66 3 of of IN cord-007796-zggk0x2q 66 4 the the DT cord-007796-zggk0x2q 66 5 genome genome NN cord-007796-zggk0x2q 66 6 makes make VBZ cord-007796-zggk0x2q 66 7 exchange exchange NN cord-007796-zggk0x2q 66 8 of of IN cord-007796-zggk0x2q 66 9 genetic genetic JJ cord-007796-zggk0x2q 66 10 material material NN cord-007796-zggk0x2q 66 11 between between IN cord-007796-zggk0x2q 66 12 subtypes subtype NNS cord-007796-zggk0x2q 66 13 possible possible JJ cord-007796-zggk0x2q 66 14 , , , cord-007796-zggk0x2q 66 15 resulting result VBG cord-007796-zggk0x2q 66 16 in in IN cord-007796-zggk0x2q 66 17 the the DT cord-007796-zggk0x2q 66 18 structural structural JJ cord-007796-zggk0x2q 66 19 changes change NNS cord-007796-zggk0x2q 66 20 observed observe VBN cord-007796-zggk0x2q 66 21 in in IN cord-007796-zggk0x2q 66 22 influenza influenza NN cord-007796-zggk0x2q 66 23 , , , cord-007796-zggk0x2q 66 24 which which WDT cord-007796-zggk0x2q 66 25 has have VBZ cord-007796-zggk0x2q 66 26 caused cause VBN cord-007796-zggk0x2q 66 27 pandemics pandemic NNS cord-007796-zggk0x2q 66 28 in in IN cord-007796-zggk0x2q 66 29 the the DT cord-007796-zggk0x2q 66 30 past past NN cord-007796-zggk0x2q 66 31 . . . cord-007796-zggk0x2q 67 1 When when WRB cord-007796-zggk0x2q 67 2 two two CD cord-007796-zggk0x2q 67 3 different different JJ cord-007796-zggk0x2q 67 4 subtypes subtype NNS cord-007796-zggk0x2q 67 5 of of IN cord-007796-zggk0x2q 67 6 influenza influenza NN cord-007796-zggk0x2q 67 7 A a DT cord-007796-zggk0x2q 67 8 virus virus NN cord-007796-zggk0x2q 67 9 infect infect VBP cord-007796-zggk0x2q 67 10 the the DT cord-007796-zggk0x2q 67 11 same same JJ cord-007796-zggk0x2q 67 12 cell cell NN cord-007796-zggk0x2q 67 13 , , , cord-007796-zggk0x2q 67 14 major major JJ cord-007796-zggk0x2q 67 15 changes change NNS cord-007796-zggk0x2q 67 16 ( ( -LRB- cord-007796-zggk0x2q 67 17 antigenic antigenic JJ cord-007796-zggk0x2q 67 18 shifts shift NNS cord-007796-zggk0x2q 67 19 ) ) -RRB- cord-007796-zggk0x2q 67 20 can can MD cord-007796-zggk0x2q 67 21 occur occur VB cord-007796-zggk0x2q 67 22 through through IN cord-007796-zggk0x2q 67 23 rearrangement rearrangement NN cord-007796-zggk0x2q 67 24 of of IN cord-007796-zggk0x2q 67 25 genetic genetic JJ cord-007796-zggk0x2q 67 26 segments segment NNS cord-007796-zggk0x2q 67 27 from from IN cord-007796-zggk0x2q 67 28 both both DT cord-007796-zggk0x2q 67 29 infecting infect VBG cord-007796-zggk0x2q 67 30 viruses virus NNS cord-007796-zggk0x2q 67 31 . . . cord-007796-zggk0x2q 68 1 Minor minor JJ cord-007796-zggk0x2q 68 2 changes change NNS cord-007796-zggk0x2q 68 3 ( ( -LRB- cord-007796-zggk0x2q 68 4 antigenic antigenic JJ cord-007796-zggk0x2q 68 5 drifts drift NNS cord-007796-zggk0x2q 68 6 ) ) -RRB- cord-007796-zggk0x2q 68 7 in in IN cord-007796-zggk0x2q 68 8 NA NA NNP cord-007796-zggk0x2q 68 9 and/or and/or CC cord-007796-zggk0x2q 68 10 HA HA NNP cord-007796-zggk0x2q 68 11 proteins protein NNS cord-007796-zggk0x2q 68 12 occur occur VBP cord-007796-zggk0x2q 68 13 through through IN cord-007796-zggk0x2q 68 14 accumulation accumulation NN cord-007796-zggk0x2q 68 15 of of IN cord-007796-zggk0x2q 68 16 point point NN cord-007796-zggk0x2q 68 17 mutations mutation NNS cord-007796-zggk0x2q 68 18 , , , cord-007796-zggk0x2q 68 19 and and CC cord-007796-zggk0x2q 68 20 provide provide VB cord-007796-zggk0x2q 68 21 a a DT cord-007796-zggk0x2q 68 22 mechanism mechanism NN cord-007796-zggk0x2q 68 23 for for IN cord-007796-zggk0x2q 68 24 the the DT cord-007796-zggk0x2q 68 25 virus virus NN cord-007796-zggk0x2q 68 26 to to TO cord-007796-zggk0x2q 68 27 escape escape VB cord-007796-zggk0x2q 68 28 protective protective JJ cord-007796-zggk0x2q 68 29 antibodies antibody NNS cord-007796-zggk0x2q 68 30 and and CC cord-007796-zggk0x2q 68 31 cause cause VB cord-007796-zggk0x2q 68 32 respiratory respiratory JJ cord-007796-zggk0x2q 68 33 symptoms symptom NNS cord-007796-zggk0x2q 68 34 every every DT cord-007796-zggk0x2q 68 35 year year NN cord-007796-zggk0x2q 68 36 . . . cord-007796-zggk0x2q 68 37 _SP cord-007796-zggk0x2q 69 1 Influenza influenza NN cord-007796-zggk0x2q 69 2 virus virus NN cord-007796-zggk0x2q 69 3 epidemics epidemic NNS cord-007796-zggk0x2q 69 4 are be VBP cord-007796-zggk0x2q 69 5 difficult difficult JJ cord-007796-zggk0x2q 69 6 to to TO cord-007796-zggk0x2q 69 7 separate separate VB cord-007796-zggk0x2q 69 8 in in IN cord-007796-zggk0x2q 69 9 time time NN cord-007796-zggk0x2q 69 10 from from IN cord-007796-zggk0x2q 69 11 RSV RSV NNP cord-007796-zggk0x2q 69 12 epidemics epidemic NNS cord-007796-zggk0x2q 69 13 , , , cord-007796-zggk0x2q 69 14 and and CC cord-007796-zggk0x2q 69 15 the the DT cord-007796-zggk0x2q 69 16 diseases disease NNS cord-007796-zggk0x2q 69 17 caused cause VBN cord-007796-zggk0x2q 69 18 by by IN cord-007796-zggk0x2q 69 19 both both DT cord-007796-zggk0x2q 69 20 viruses virus NNS cord-007796-zggk0x2q 69 21 can can MD cord-007796-zggk0x2q 69 22 also also RB cord-007796-zggk0x2q 69 23 be be VB cord-007796-zggk0x2q 69 24 difficult difficult JJ cord-007796-zggk0x2q 69 25 to to TO cord-007796-zggk0x2q 69 26 differentiate differentiate VB cord-007796-zggk0x2q 69 27 ( ( -LRB- cord-007796-zggk0x2q 69 28 Zambon Zambon NNP cord-007796-zggk0x2q 69 29 et et NNP cord-007796-zggk0x2q 69 30 al al NNP cord-007796-zggk0x2q 69 31 . . NNP cord-007796-zggk0x2q 69 32 , , , cord-007796-zggk0x2q 69 33 2001 2001 CD cord-007796-zggk0x2q 69 34 ) ) -RRB- cord-007796-zggk0x2q 69 35 . . . cord-007796-zggk0x2q 70 1 ( ( -LRB- cord-007796-zggk0x2q 70 2 Figure figure NN cord-007796-zggk0x2q 70 3 4 4 CD cord-007796-zggk0x2q 70 4 .1 .1 CD cord-007796-zggk0x2q 70 5 ) ) -RRB- cord-007796-zggk0x2q 71 1 Compared compare VBN cord-007796-zggk0x2q 71 2 to to IN cord-007796-zggk0x2q 71 3 other other JJ cord-007796-zggk0x2q 71 4 viruses virus NNS cord-007796-zggk0x2q 71 5 , , , cord-007796-zggk0x2q 71 6 morbidity morbidity NN cord-007796-zggk0x2q 71 7 caused cause VBN cord-007796-zggk0x2q 71 8 by by IN cord-007796-zggk0x2q 71 9 influenza influenza NN cord-007796-zggk0x2q 71 10 is be VBZ cord-007796-zggk0x2q 71 11 high high JJ cord-007796-zggk0x2q 71 12 in in IN cord-007796-zggk0x2q 71 13 all all DT cord-007796-zggk0x2q 71 14 age age NN cord-007796-zggk0x2q 71 15 groups group NNS cord-007796-zggk0x2q 71 16 . . . cord-007796-zggk0x2q 72 1 Children child NNS cord-007796-zggk0x2q 72 2 with with IN cord-007796-zggk0x2q 72 3 influenza influenza NN cord-007796-zggk0x2q 72 4 infection infection NN cord-007796-zggk0x2q 72 5 of of IN cord-007796-zggk0x2q 72 6 the the DT cord-007796-zggk0x2q 72 7 respiratory respiratory JJ cord-007796-zggk0x2q 72 8 tract tract NN cord-007796-zggk0x2q 72 9 are be VBP cord-007796-zggk0x2q 72 10 more more RBR cord-007796-zggk0x2q 72 11 likely likely JJ cord-007796-zggk0x2q 72 12 to to TO cord-007796-zggk0x2q 72 13 present present VB cord-007796-zggk0x2q 72 14 with with IN cord-007796-zggk0x2q 72 15 fever fever NN cord-007796-zggk0x2q 72 16 . . . cord-007796-zggk0x2q 73 1 Infants infant NNS cord-007796-zggk0x2q 73 2 aged aged JJ cord-007796-zggk0x2q 73 3 less less JJR cord-007796-zggk0x2q 73 4 than than IN cord-007796-zggk0x2q 73 5 6 6 CD cord-007796-zggk0x2q 73 6 months month NNS cord-007796-zggk0x2q 73 7 and and CC cord-007796-zggk0x2q 73 8 older old JJR cord-007796-zggk0x2q 73 9 children child NNS cord-007796-zggk0x2q 73 10 with with IN cord-007796-zggk0x2q 73 11 an an DT cord-007796-zggk0x2q 73 12 impaired impaired JJ cord-007796-zggk0x2q 73 13 immune immune JJ cord-007796-zggk0x2q 73 14 system system NN cord-007796-zggk0x2q 73 15 , , , cord-007796-zggk0x2q 73 16 or or CC cord-007796-zggk0x2q 73 17 other other JJ cord-007796-zggk0x2q 73 18 serious serious JJ cord-007796-zggk0x2q 73 19 health health NN cord-007796-zggk0x2q 73 20 problems problem NNS cord-007796-zggk0x2q 73 21 , , , cord-007796-zggk0x2q 73 22 have have VBP cord-007796-zggk0x2q 73 23 a a DT cord-007796-zggk0x2q 73 24 higher high JJR cord-007796-zggk0x2q 73 25 risk risk NN cord-007796-zggk0x2q 73 26 of of IN cord-007796-zggk0x2q 73 27 hospitalization hospitalization NN cord-007796-zggk0x2q 73 28 and and CC cord-007796-zggk0x2q 73 29 mortality mortality NN cord-007796-zggk0x2q 73 30 . . . cord-007796-zggk0x2q 74 1 Subclinical subclinical JJ cord-007796-zggk0x2q 74 2 infections infection NNS cord-007796-zggk0x2q 74 3 with with IN cord-007796-zggk0x2q 74 4 influenza influenza NN cord-007796-zggk0x2q 74 5 in in IN cord-007796-zggk0x2q 74 6 children child NNS cord-007796-zggk0x2q 74 7 are be VBP cord-007796-zggk0x2q 74 8 common common JJ cord-007796-zggk0x2q 74 9 , , , cord-007796-zggk0x2q 74 10 suggesting suggest VBG cord-007796-zggk0x2q 74 11 children child NNS cord-007796-zggk0x2q 74 12 can can MD cord-007796-zggk0x2q 74 13 be be VB cord-007796-zggk0x2q 74 14 an an DT cord-007796-zggk0x2q 74 15 important important JJ cord-007796-zggk0x2q 74 16 reservoir reservoir NN cord-007796-zggk0x2q 74 17 and and CC cord-007796-zggk0x2q 74 18 source source NN cord-007796-zggk0x2q 74 19 of of IN cord-007796-zggk0x2q 74 20 transmission transmission NN cord-007796-zggk0x2q 74 21 . . . cord-007796-zggk0x2q 75 1 Yearly yearly JJ cord-007796-zggk0x2q 75 2 updated update VBN cord-007796-zggk0x2q 75 3 vaccines vaccine NNS cord-007796-zggk0x2q 75 4 are be VBP cord-007796-zggk0x2q 75 5 available available JJ cord-007796-zggk0x2q 75 6 and and CC cord-007796-zggk0x2q 75 7 effective effective JJ cord-007796-zggk0x2q 75 8 , , , cord-007796-zggk0x2q 75 9 and and CC cord-007796-zggk0x2q 75 10 recently recently RB cord-007796-zggk0x2q 75 11 it -PRON- PRP cord-007796-zggk0x2q 75 12 has have VBZ cord-007796-zggk0x2q 75 13 been be VBN cord-007796-zggk0x2q 75 14 proposed propose VBN cord-007796-zggk0x2q 75 15 to to TO cord-007796-zggk0x2q 75 16 extend extend VB cord-007796-zggk0x2q 75 17 the the DT cord-007796-zggk0x2q 75 18 current current JJ cord-007796-zggk0x2q 75 19 recommendations recommendation NNS cord-007796-zggk0x2q 75 20 to to IN cord-007796-zggk0x2q 75 21 children child NNS cord-007796-zggk0x2q 75 22 less less JJR cord-007796-zggk0x2q 75 23 than than IN cord-007796-zggk0x2q 75 24 2 2 CD cord-007796-zggk0x2q 75 25 years year NNS cord-007796-zggk0x2q 75 26 of of IN cord-007796-zggk0x2q 75 27 age age NN cord-007796-zggk0x2q 75 28 , , , cord-007796-zggk0x2q 75 29 children child NNS cord-007796-zggk0x2q 75 30 with with IN cord-007796-zggk0x2q 75 31 recurrent recurrent JJ cord-007796-zggk0x2q 75 32 acute acute JJ cord-007796-zggk0x2q 75 33 otitis otitis NN cord-007796-zggk0x2q 75 34 media medium NNS cord-007796-zggk0x2q 75 35 or or CC cord-007796-zggk0x2q 75 36 respiratory respiratory JJ cord-007796-zggk0x2q 75 37 tract tract NN cord-007796-zggk0x2q 75 38 infections infection NNS cord-007796-zggk0x2q 75 39 , , , cord-007796-zggk0x2q 75 40 and and CC cord-007796-zggk0x2q 75 41 healthy healthy JJ cord-007796-zggk0x2q 75 42 children child NNS cord-007796-zggk0x2q 75 43 attending attend VBG cord-007796-zggk0x2q 75 44 day day NN cord-007796-zggk0x2q 75 45 - - HYPH cord-007796-zggk0x2q 75 46 care care NN cord-007796-zggk0x2q 75 47 centers center NNS cord-007796-zggk0x2q 75 48 or or CC cord-007796-zggk0x2q 75 49 elementary elementary JJ cord-007796-zggk0x2q 75 50 schools school NNS cord-007796-zggk0x2q 75 51 ( ( -LRB- cord-007796-zggk0x2q 75 52 Principi Principi NNP cord-007796-zggk0x2q 75 53 and and CC cord-007796-zggk0x2q 75 54 Esposito Esposito NNP cord-007796-zggk0x2q 75 55 , , , cord-007796-zggk0x2q 75 56 2004 2004 CD cord-007796-zggk0x2q 75 57 ) ) -RRB- cord-007796-zggk0x2q 75 58 . . . cord-007796-zggk0x2q 76 1 Adenoviruses adenovirus NNS cord-007796-zggk0x2q 76 2 , , , cord-007796-zggk0x2q 76 3 belonging belong VBG cord-007796-zggk0x2q 76 4 to to IN cord-007796-zggk0x2q 76 5 the the DT cord-007796-zggk0x2q 76 6 adenoviridae adenoviridae NNP cord-007796-zggk0x2q 76 7 family family NN cord-007796-zggk0x2q 76 8 and and CC cord-007796-zggk0x2q 76 9 the the DT cord-007796-zggk0x2q 76 10 genus genus NN cord-007796-zggk0x2q 77 1 Mastadenovirus Mastadenovirus NNP cord-007796-zggk0x2q 77 2 , , , cord-007796-zggk0x2q 77 3 are be VBP cord-007796-zggk0x2q 77 4 a a DT cord-007796-zggk0x2q 77 5 group group NN cord-007796-zggk0x2q 77 6 of of IN cord-007796-zggk0x2q 77 7 DNA dna NN cord-007796-zggk0x2q 77 8 - - HYPH cord-007796-zggk0x2q 77 9 viruses virus NNS cord-007796-zggk0x2q 77 10 of of IN cord-007796-zggk0x2q 77 11 which which WDT cord-007796-zggk0x2q 77 12 at at IN cord-007796-zggk0x2q 77 13 least least JJS cord-007796-zggk0x2q 77 14 47 47 CD cord-007796-zggk0x2q 77 15 serotypes serotype NNS cord-007796-zggk0x2q 77 16 are be VBP cord-007796-zggk0x2q 77 17 known know VBN cord-007796-zggk0x2q 77 18 . . . cord-007796-zggk0x2q 78 1 For for IN cord-007796-zggk0x2q 78 2 lower low JJR cord-007796-zggk0x2q 78 3 respiratory respiratory JJ cord-007796-zggk0x2q 78 4 disease disease NN cord-007796-zggk0x2q 78 5 , , , cord-007796-zggk0x2q 78 6 subtypes subtype NNS cord-007796-zggk0x2q 78 7 1 1 CD cord-007796-zggk0x2q 78 8 , , , cord-007796-zggk0x2q 78 9 2 2 CD cord-007796-zggk0x2q 78 10 , , , cord-007796-zggk0x2q 78 11 3 3 CD cord-007796-zggk0x2q 78 12 , , , cord-007796-zggk0x2q 78 13 4 4 CD cord-007796-zggk0x2q 78 14 , , , cord-007796-zggk0x2q 78 15 5 5 CD cord-007796-zggk0x2q 78 16 , , , cord-007796-zggk0x2q 78 17 7 7 CD cord-007796-zggk0x2q 78 18 , , , cord-007796-zggk0x2q 78 19 and and CC cord-007796-zggk0x2q 78 20 21 21 CD cord-007796-zggk0x2q 78 21 are be VBP cord-007796-zggk0x2q 78 22 most most RBS cord-007796-zggk0x2q 78 23 important important JJ cord-007796-zggk0x2q 78 24 . . . cord-007796-zggk0x2q 79 1 It -PRON- PRP cord-007796-zggk0x2q 79 2 is be VBZ cord-007796-zggk0x2q 79 3 an an DT cord-007796-zggk0x2q 79 4 icosahedral icosahedral JJ cord-007796-zggk0x2q 79 5 capsid capsid NN cord-007796-zggk0x2q 79 6 virus virus NN cord-007796-zggk0x2q 79 7 with with IN cord-007796-zggk0x2q 79 8 extruding extrude VBG cord-007796-zggk0x2q 79 9 fiber fiber NN cord-007796-zggk0x2q 79 10 proteins protein NNS cord-007796-zggk0x2q 79 11 , , , cord-007796-zggk0x2q 79 12 which which WDT cord-007796-zggk0x2q 79 13 are be VBP cord-007796-zggk0x2q 79 14 required require VBN cord-007796-zggk0x2q 79 15 for for IN cord-007796-zggk0x2q 79 16 viral viral JJ cord-007796-zggk0x2q 79 17 entry entry NN cord-007796-zggk0x2q 79 18 to to IN cord-007796-zggk0x2q 79 19 epithelial epithelial JJ cord-007796-zggk0x2q 79 20 cells cell NNS cord-007796-zggk0x2q 80 1 ( ( -LRB- cord-007796-zggk0x2q 80 2 Howitt Howitt NNP cord-007796-zggk0x2q 80 3 et et FW cord-007796-zggk0x2q 80 4 al al NNP cord-007796-zggk0x2q 80 5 . . NNP cord-007796-zggk0x2q 80 6 , , , cord-007796-zggk0x2q 80 7 2003 2003 CD cord-007796-zggk0x2q 80 8 ) ) -RRB- cord-007796-zggk0x2q 80 9 . . . cord-007796-zggk0x2q 81 1 Although although IN cord-007796-zggk0x2q 81 2 human human JJ cord-007796-zggk0x2q 81 3 adenoviruses adenovirus NNS cord-007796-zggk0x2q 81 4 are be VBP cord-007796-zggk0x2q 81 5 ubiquitous ubiquitous JJ cord-007796-zggk0x2q 81 6 , , , cord-007796-zggk0x2q 81 7 and and CC cord-007796-zggk0x2q 81 8 cause cause VB cord-007796-zggk0x2q 81 9 primary primary JJ cord-007796-zggk0x2q 81 10 infection infection NN cord-007796-zggk0x2q 81 11 in in IN cord-007796-zggk0x2q 81 12 the the DT cord-007796-zggk0x2q 81 13 first first JJ cord-007796-zggk0x2q 81 14 year year NN cord-007796-zggk0x2q 81 15 of of IN cord-007796-zggk0x2q 81 16 life life NN cord-007796-zggk0x2q 81 17 , , , cord-007796-zggk0x2q 81 18 there there EX cord-007796-zggk0x2q 81 19 is be VBZ cord-007796-zggk0x2q 81 20 geographical geographical JJ cord-007796-zggk0x2q 81 21 variation variation NN cord-007796-zggk0x2q 81 22 in in IN cord-007796-zggk0x2q 81 23 the the DT cord-007796-zggk0x2q 81 24 distribution distribution NN cord-007796-zggk0x2q 81 25 of of IN cord-007796-zggk0x2q 81 26 serotypes serotype NNS cord-007796-zggk0x2q 81 27 and and CC cord-007796-zggk0x2q 81 28 in in IN cord-007796-zggk0x2q 81 29 the the DT cord-007796-zggk0x2q 81 30 association association NN cord-007796-zggk0x2q 81 31 of of IN cord-007796-zggk0x2q 81 32 serotypes serotypes NNP cord-007796-zggk0x2q 81 33 with with IN cord-007796-zggk0x2q 81 34 different different JJ cord-007796-zggk0x2q 81 35 age age NN cord-007796-zggk0x2q 81 36 groups group NNS cord-007796-zggk0x2q 81 37 . . . cord-007796-zggk0x2q 82 1 In in IN cord-007796-zggk0x2q 82 2 Europe Europe NNP cord-007796-zggk0x2q 82 3 , , , cord-007796-zggk0x2q 82 4 adenovirus adenovirus NN cord-007796-zggk0x2q 82 5 is be VBZ cord-007796-zggk0x2q 82 6 the the DT cord-007796-zggk0x2q 82 7 cause cause NN cord-007796-zggk0x2q 82 8 of of IN cord-007796-zggk0x2q 82 9 infection infection NN cord-007796-zggk0x2q 82 10 in in IN cord-007796-zggk0x2q 82 11 approximately approximately RB cord-007796-zggk0x2q 82 12 5 5 CD cord-007796-zggk0x2q 82 13 % % NN cord-007796-zggk0x2q 82 14 of of IN cord-007796-zggk0x2q 82 15 hospitalized hospitalize VBN cord-007796-zggk0x2q 82 16 patients patient NNS cord-007796-zggk0x2q 82 17 with with IN cord-007796-zggk0x2q 82 18 viral viral JJ cord-007796-zggk0x2q 82 19 lower low JJR cord-007796-zggk0x2q 82 20 respiratory respiratory JJ cord-007796-zggk0x2q 82 21 tract tract NN cord-007796-zggk0x2q 82 22 disease disease NN cord-007796-zggk0x2q 82 23 . . . cord-007796-zggk0x2q 83 1 However however RB cord-007796-zggk0x2q 83 2 , , , cord-007796-zggk0x2q 83 3 in in IN cord-007796-zggk0x2q 83 4 some some DT cord-007796-zggk0x2q 83 5 South south JJ cord-007796-zggk0x2q 83 6 American american JJ cord-007796-zggk0x2q 83 7 and and CC cord-007796-zggk0x2q 83 8 Asian asian JJ cord-007796-zggk0x2q 83 9 countries country NNS cord-007796-zggk0x2q 83 10 , , , cord-007796-zggk0x2q 83 11 adenovirus adenovirus NN cord-007796-zggk0x2q 83 12 is be VBZ cord-007796-zggk0x2q 83 13 the the DT cord-007796-zggk0x2q 83 14 second second JJ cord-007796-zggk0x2q 83 15 most most RBS cord-007796-zggk0x2q 83 16 prevalent prevalent JJ cord-007796-zggk0x2q 83 17 pathogen pathogen NN cord-007796-zggk0x2q 83 18 for for IN cord-007796-zggk0x2q 83 19 acute acute JJ cord-007796-zggk0x2q 83 20 lower low JJR cord-007796-zggk0x2q 83 21 respiratory respiratory JJ cord-007796-zggk0x2q 83 22 tract tract NN cord-007796-zggk0x2q 83 23 infection infection NN cord-007796-zggk0x2q 83 24 in in IN cord-007796-zggk0x2q 83 25 children child NNS cord-007796-zggk0x2q 83 26 after after IN cord-007796-zggk0x2q 83 27 RSV RSV NNP cord-007796-zggk0x2q 84 1 ( ( -LRB- cord-007796-zggk0x2q 84 2 Carballal Carballal NNP cord-007796-zggk0x2q 84 3 et et NNP cord-007796-zggk0x2q 84 4 al al NNP cord-007796-zggk0x2q 84 5 . . NNP cord-007796-zggk0x2q 84 6 , , , cord-007796-zggk0x2q 84 7 2002 2002 CD cord-007796-zggk0x2q 84 8 ) ) -RRB- cord-007796-zggk0x2q 84 9 . . . cord-007796-zggk0x2q 85 1 Although although IN cord-007796-zggk0x2q 85 2 adenovirus adenovirus NN cord-007796-zggk0x2q 85 3 infections infection NNS cord-007796-zggk0x2q 85 4 in in IN cord-007796-zggk0x2q 85 5 general general JJ cord-007796-zggk0x2q 85 6 occur occur VBP cord-007796-zggk0x2q 85 7 the the DT cord-007796-zggk0x2q 85 8 whole whole JJ cord-007796-zggk0x2q 85 9 year year NN cord-007796-zggk0x2q 85 10 round round NN cord-007796-zggk0x2q 85 11 , , , cord-007796-zggk0x2q 85 12 respiratory respiratory JJ cord-007796-zggk0x2q 85 13 adenovirus adenovirus NN cord-007796-zggk0x2q 85 14 infections infection NNS cord-007796-zggk0x2q 85 15 are be VBP cord-007796-zggk0x2q 85 16 most most RBS cord-007796-zggk0x2q 85 17 common common JJ cord-007796-zggk0x2q 85 18 during during IN cord-007796-zggk0x2q 85 19 late late JJ cord-007796-zggk0x2q 85 20 winter winter NN cord-007796-zggk0x2q 85 21 , , , cord-007796-zggk0x2q 85 22 spring spring NN cord-007796-zggk0x2q 85 23 , , , cord-007796-zggk0x2q 85 24 and and CC cord-007796-zggk0x2q 85 25 early early JJ cord-007796-zggk0x2q 85 26 summer summer NN cord-007796-zggk0x2q 85 27 . . . cord-007796-zggk0x2q 86 1 Adenovirus Adenovirus NNP cord-007796-zggk0x2q 86 2 type type NN cord-007796-zggk0x2q 86 3 7 7 CD cord-007796-zggk0x2q 86 4 , , , cord-007796-zggk0x2q 86 5 acquired acquire VBN cord-007796-zggk0x2q 86 6 by by IN cord-007796-zggk0x2q 86 7 inhalation inhalation NN cord-007796-zggk0x2q 86 8 , , , cord-007796-zggk0x2q 86 9 has have VBZ cord-007796-zggk0x2q 86 10 been be VBN cord-007796-zggk0x2q 86 11 associated associate VBN cord-007796-zggk0x2q 86 12 with with IN cord-007796-zggk0x2q 86 13 more more RBR cord-007796-zggk0x2q 86 14 severe severe JJ cord-007796-zggk0x2q 86 15 lower low JJR cord-007796-zggk0x2q 86 16 respiratory respiratory JJ cord-007796-zggk0x2q 86 17 tract tract NN cord-007796-zggk0x2q 86 18 disease disease NN cord-007796-zggk0x2q 86 19 ( ( -LRB- cord-007796-zggk0x2q 86 20 Larranaga Larranaga NNP cord-007796-zggk0x2q 86 21 et et NNP cord-007796-zggk0x2q 86 22 al al NNP cord-007796-zggk0x2q 86 23 . . NNP cord-007796-zggk0x2q 86 24 , , , cord-007796-zggk0x2q 86 25 2000 2000 CD cord-007796-zggk0x2q 86 26 ) ) -RRB- cord-007796-zggk0x2q 86 27 . . . cord-007796-zggk0x2q 87 1 Subtype subtype NN cord-007796-zggk0x2q 87 2 - - HYPH cord-007796-zggk0x2q 87 3 specific specific JJ cord-007796-zggk0x2q 87 4 immunity immunity NN cord-007796-zggk0x2q 87 5 occurs occur VBZ cord-007796-zggk0x2q 87 6 . . . cord-007796-zggk0x2q 88 1 However however RB cord-007796-zggk0x2q 88 2 , , , cord-007796-zggk0x2q 88 3 some some DT cord-007796-zggk0x2q 88 4 types type NNS cord-007796-zggk0x2q 88 5 are be VBP cord-007796-zggk0x2q 88 6 capable capable JJ cord-007796-zggk0x2q 88 7 of of IN cord-007796-zggk0x2q 88 8 establishing establish VBG cord-007796-zggk0x2q 88 9 persistent persistent JJ cord-007796-zggk0x2q 88 10 asymptomatic asymptomatic JJ cord-007796-zggk0x2q 88 11 infections infection NNS cord-007796-zggk0x2q 88 12 in in IN cord-007796-zggk0x2q 88 13 tonsils tonsil NNS cord-007796-zggk0x2q 88 14 , , , cord-007796-zggk0x2q 88 15 adenoids adenoid NNS cord-007796-zggk0x2q 88 16 , , , cord-007796-zggk0x2q 88 17 and and CC cord-007796-zggk0x2q 88 18 intestines intestine NNS cord-007796-zggk0x2q 88 19 of of IN cord-007796-zggk0x2q 88 20 infected infected JJ cord-007796-zggk0x2q 88 21 hosts host NNS cord-007796-zggk0x2q 88 22 , , , cord-007796-zggk0x2q 88 23 and and CC cord-007796-zggk0x2q 88 24 shedding shedding NN cord-007796-zggk0x2q 88 25 can can MD cord-007796-zggk0x2q 88 26 occur occur VB cord-007796-zggk0x2q 88 27 for for IN cord-007796-zggk0x2q 88 28 months month NNS cord-007796-zggk0x2q 88 29 or or CC cord-007796-zggk0x2q 88 30 years year NNS cord-007796-zggk0x2q 88 31 . . . cord-007796-zggk0x2q 89 1 children child NNS cord-007796-zggk0x2q 89 2 under under IN cord-007796-zggk0x2q 89 3 6-years 6-years CD cord-007796-zggk0x2q 89 4 old old JJ cord-007796-zggk0x2q 89 5 . . . cord-007796-zggk0x2q 90 1 Though though IN cord-007796-zggk0x2q 90 2 it -PRON- PRP cord-007796-zggk0x2q 90 3 is be VBZ cord-007796-zggk0x2q 90 4 the the DT cord-007796-zggk0x2q 90 5 causative causative JJ cord-007796-zggk0x2q 90 6 agent agent NN cord-007796-zggk0x2q 90 7 of of IN cord-007796-zggk0x2q 90 8 similar similar JJ cord-007796-zggk0x2q 90 9 disease disease NN cord-007796-zggk0x2q 90 10 entities entity NNS cord-007796-zggk0x2q 90 11 , , , cord-007796-zggk0x2q 90 12 hospitalizations hospitalization NNS cord-007796-zggk0x2q 90 13 occur occur VBP cord-007796-zggk0x2q 90 14 four four CD cord-007796-zggk0x2q 90 15 times time NNS cord-007796-zggk0x2q 90 16 less less RBR cord-007796-zggk0x2q 90 17 frequently frequently RB cord-007796-zggk0x2q 90 18 than than IN cord-007796-zggk0x2q 90 19 for for IN cord-007796-zggk0x2q 90 20 RSV RSV NNP cord-007796-zggk0x2q 90 21 infections infection NNS cord-007796-zggk0x2q 90 22 ( ( -LRB- cord-007796-zggk0x2q 90 23 Hall Hall NNP cord-007796-zggk0x2q 90 24 , , , cord-007796-zggk0x2q 90 25 2001 2001 CD cord-007796-zggk0x2q 90 26 ) ) -RRB- cord-007796-zggk0x2q 90 27 . . . cord-007796-zggk0x2q 91 1 Two two CD cord-007796-zggk0x2q 91 2 subtypes subtype NNS cord-007796-zggk0x2q 91 3 are be VBP cord-007796-zggk0x2q 91 4 clinically clinically RB cord-007796-zggk0x2q 91 5 important important JJ cord-007796-zggk0x2q 91 6 respiratory respiratory JJ cord-007796-zggk0x2q 91 7 pathogens pathogen NNS cord-007796-zggk0x2q 91 8 in in IN cord-007796-zggk0x2q 91 9 children child NNS cord-007796-zggk0x2q 91 10 , , , cord-007796-zggk0x2q 91 11 PIV-1 PIV-1 NNP cord-007796-zggk0x2q 91 12 and and CC cord-007796-zggk0x2q 91 13 PIV-3 PIV-3 NNP cord-007796-zggk0x2q 91 14 . . . cord-007796-zggk0x2q 92 1 PIV-1 PIV-1 NNP cord-007796-zggk0x2q 92 2 is be VBZ cord-007796-zggk0x2q 92 3 the the DT cord-007796-zggk0x2q 92 4 main main JJ cord-007796-zggk0x2q 92 5 cause cause NN cord-007796-zggk0x2q 92 6 of of IN cord-007796-zggk0x2q 92 7 croup croup NN cord-007796-zggk0x2q 92 8 in in IN cord-007796-zggk0x2q 92 9 2 2 CD cord-007796-zggk0x2q 92 10 - - HYPH cord-007796-zggk0x2q 92 11 6-year 6-year JJ cord-007796-zggk0x2q 92 12 olds old NNS cord-007796-zggk0x2q 92 13 , , , cord-007796-zggk0x2q 92 14 while while IN cord-007796-zggk0x2q 92 15 PIV-3 PIV-3 NNP cord-007796-zggk0x2q 92 16 is be VBZ cord-007796-zggk0x2q 92 17 responsible responsible JJ cord-007796-zggk0x2q 92 18 for for IN cord-007796-zggk0x2q 92 19 parainfluenza parainfluenza NNP cord-007796-zggk0x2q 92 20 bronchiolitis bronchiolitis NNP cord-007796-zggk0x2q 92 21 in in IN cord-007796-zggk0x2q 92 22 children child NNS cord-007796-zggk0x2q 92 23 under under IN cord-007796-zggk0x2q 92 24 6-months 6-months CD cord-007796-zggk0x2q 92 25 old old JJ cord-007796-zggk0x2q 92 26 . . . cord-007796-zggk0x2q 93 1 PIV-4 piv-4 NN cord-007796-zggk0x2q 93 2 only only RB cord-007796-zggk0x2q 93 3 causes cause VBZ cord-007796-zggk0x2q 93 4 mild mild JJ cord-007796-zggk0x2q 93 5 upper upper JJ cord-007796-zggk0x2q 93 6 respiratory respiratory JJ cord-007796-zggk0x2q 93 7 tract tract NN cord-007796-zggk0x2q 93 8 infections infection NNS cord-007796-zggk0x2q 93 9 . . . cord-007796-zggk0x2q 94 1 Because because IN cord-007796-zggk0x2q 94 2 of of IN cord-007796-zggk0x2q 94 3 acute acute JJ cord-007796-zggk0x2q 94 4 narrowing narrowing NN cord-007796-zggk0x2q 94 5 of of IN cord-007796-zggk0x2q 94 6 the the DT cord-007796-zggk0x2q 94 7 subglottic subglottic JJ cord-007796-zggk0x2q 94 8 region region NN cord-007796-zggk0x2q 94 9 of of IN cord-007796-zggk0x2q 94 10 the the DT cord-007796-zggk0x2q 94 11 larynx larynx NN cord-007796-zggk0x2q 94 12 , , , cord-007796-zggk0x2q 94 13 moderate moderate JJ cord-007796-zggk0x2q 94 14 to to IN cord-007796-zggk0x2q 94 15 severe severe JJ cord-007796-zggk0x2q 94 16 croup croup NN cord-007796-zggk0x2q 94 17 may may MD cord-007796-zggk0x2q 94 18 require require VB cord-007796-zggk0x2q 94 19 emergency emergency NN cord-007796-zggk0x2q 94 20 management management NN cord-007796-zggk0x2q 94 21 with with IN cord-007796-zggk0x2q 94 22 systemic systemic JJ cord-007796-zggk0x2q 94 23 or or CC cord-007796-zggk0x2q 94 24 inhaled inhaled JJ cord-007796-zggk0x2q 94 25 corticosteroids corticosteroid NNS cord-007796-zggk0x2q 94 26 , , , cord-007796-zggk0x2q 94 27 which which WDT cord-007796-zggk0x2q 94 28 are be VBP cord-007796-zggk0x2q 94 29 effective effective JJ cord-007796-zggk0x2q 94 30 in in IN cord-007796-zggk0x2q 94 31 improving improve VBG cord-007796-zggk0x2q 94 32 stridor stridor NNS cord-007796-zggk0x2q 94 33 in in IN cord-007796-zggk0x2q 94 34 a a DT cord-007796-zggk0x2q 94 35 few few JJ cord-007796-zggk0x2q 94 36 hours hour NNS cord-007796-zggk0x2q 95 1 ( ( -LRB- cord-007796-zggk0x2q 95 2 Cetinkaya Cetinkaya NNP cord-007796-zggk0x2q 95 3 et et NNP cord-007796-zggk0x2q 95 4 al al NNP cord-007796-zggk0x2q 95 5 . . NNP cord-007796-zggk0x2q 95 6 , , , cord-007796-zggk0x2q 95 7 2004 2004 CD cord-007796-zggk0x2q 95 8 ) ) -RRB- cord-007796-zggk0x2q 95 9 . . . cord-007796-zggk0x2q 96 1 The the DT cord-007796-zggk0x2q 96 2 hallmark hallmark JJ cord-007796-zggk0x2q 96 3 cytopathic cytopathic JJ cord-007796-zggk0x2q 96 4 effect effect NN cord-007796-zggk0x2q 96 5 of of IN cord-007796-zggk0x2q 96 6 acute acute JJ cord-007796-zggk0x2q 96 7 infection infection NN cord-007796-zggk0x2q 96 8 with with IN cord-007796-zggk0x2q 96 9 PIV-3 PIV-3 NNP cord-007796-zggk0x2q 96 10 is be VBZ cord-007796-zggk0x2q 96 11 comparable comparable JJ cord-007796-zggk0x2q 96 12 to to IN cord-007796-zggk0x2q 96 13 that that DT cord-007796-zggk0x2q 96 14 of of IN cord-007796-zggk0x2q 96 15 RSV RSV NNP cord-007796-zggk0x2q 96 16 with with IN cord-007796-zggk0x2q 96 17 extensive extensive JJ cord-007796-zggk0x2q 96 18 cell cell NN cord-007796-zggk0x2q 96 19 fusion fusion NN cord-007796-zggk0x2q 96 20 resulting result VBG cord-007796-zggk0x2q 96 21 in in IN cord-007796-zggk0x2q 96 22 syncytium syncytium NN cord-007796-zggk0x2q 96 23 formation formation NN cord-007796-zggk0x2q 96 24 . . . cord-007796-zggk0x2q 97 1 For for IN cord-007796-zggk0x2q 97 2 fusion fusion NN cord-007796-zggk0x2q 97 3 to to TO cord-007796-zggk0x2q 97 4 occur occur VB cord-007796-zggk0x2q 97 5 , , , cord-007796-zggk0x2q 97 6 two two CD cord-007796-zggk0x2q 97 7 PIV PIV NNP cord-007796-zggk0x2q 97 8 glycoproteins glycoprotein NNS cord-007796-zggk0x2q 97 9 are be VBP cord-007796-zggk0x2q 97 10 required require VBN cord-007796-zggk0x2q 97 11 , , , cord-007796-zggk0x2q 97 12 including include VBG cord-007796-zggk0x2q 97 13 the the DT cord-007796-zggk0x2q 97 14 hemagglutinin hemagglutinin NN cord-007796-zggk0x2q 97 15 - - , cord-007796-zggk0x2q 97 16 neuraminidase neuraminidase FW cord-007796-zggk0x2q 97 17 ( ( -LRB- cord-007796-zggk0x2q 97 18 HN HN NNP cord-007796-zggk0x2q 97 19 ) ) -RRB- cord-007796-zggk0x2q 97 20 glycoprotein glycoprotein NN cord-007796-zggk0x2q 97 21 interacting interact VBG cord-007796-zggk0x2q 97 22 with with IN cord-007796-zggk0x2q 97 23 host host NN cord-007796-zggk0x2q 97 24 cell cell NN cord-007796-zggk0x2q 97 25 sialic sialic NN cord-007796-zggk0x2q 97 26 acid acid NN cord-007796-zggk0x2q 97 27 receptor receptor NN cord-007796-zggk0x2q 97 28 and and CC cord-007796-zggk0x2q 97 29 the the DT cord-007796-zggk0x2q 97 30 viral viral JJ cord-007796-zggk0x2q 97 31 fusion fusion NN cord-007796-zggk0x2q 97 32 ( ( -LRB- cord-007796-zggk0x2q 97 33 F F NNP cord-007796-zggk0x2q 97 34 ) ) -RRB- cord-007796-zggk0x2q 97 35 glycoprotein glycoprotein NN cord-007796-zggk0x2q 97 36 . . . cord-007796-zggk0x2q 98 1 Rhinovirus rhinovirus NN cord-007796-zggk0x2q 98 2 infections infection NNS cord-007796-zggk0x2q 98 3 account account VBP cord-007796-zggk0x2q 98 4 for for IN cord-007796-zggk0x2q 98 5 the the DT cord-007796-zggk0x2q 98 6 largest large JJS cord-007796-zggk0x2q 98 7 number number NN cord-007796-zggk0x2q 98 8 of of IN cord-007796-zggk0x2q 98 9 respiratory respiratory JJ cord-007796-zggk0x2q 98 10 tract tract NN cord-007796-zggk0x2q 98 11 infections infection NNS cord-007796-zggk0x2q 98 12 in in IN cord-007796-zggk0x2q 98 13 children child NNS cord-007796-zggk0x2q 98 14 . . . cord-007796-zggk0x2q 99 1 However however RB cord-007796-zggk0x2q 99 2 , , , cord-007796-zggk0x2q 99 3 rhinovirus rhinovirus NN cord-007796-zggk0x2q 99 4 infections infection NNS cord-007796-zggk0x2q 99 5 produce produce VBP cord-007796-zggk0x2q 99 6 mild mild JJ cord-007796-zggk0x2q 99 7 symptoms symptom NNS cord-007796-zggk0x2q 99 8 compared compare VBN cord-007796-zggk0x2q 99 9 to to IN cord-007796-zggk0x2q 99 10 RSV RSV NNP cord-007796-zggk0x2q 99 11 , , , cord-007796-zggk0x2q 99 12 PIV PIV NNP cord-007796-zggk0x2q 99 13 , , , cord-007796-zggk0x2q 99 14 and and CC cord-007796-zggk0x2q 99 15 influenzavirus influenzavirus NN cord-007796-zggk0x2q 99 16 . . . cord-007796-zggk0x2q 100 1 Most Most JJS cord-007796-zggk0x2q 100 2 of of IN cord-007796-zggk0x2q 100 3 the the DT cord-007796-zggk0x2q 100 4 symptoms symptom NNS cord-007796-zggk0x2q 100 5 caused cause VBN cord-007796-zggk0x2q 100 6 by by IN cord-007796-zggk0x2q 100 7 rhinovirus rhinovirus NN cord-007796-zggk0x2q 100 8 are be VBP cord-007796-zggk0x2q 100 9 confined confine VBN cord-007796-zggk0x2q 100 10 to to IN cord-007796-zggk0x2q 100 11 the the DT cord-007796-zggk0x2q 100 12 upper upper JJ cord-007796-zggk0x2q 100 13 respiratory respiratory JJ cord-007796-zggk0x2q 100 14 tract tract NN cord-007796-zggk0x2q 100 15 . . . cord-007796-zggk0x2q 101 1 Although although IN cord-007796-zggk0x2q 101 2 present present JJ cord-007796-zggk0x2q 101 3 in in IN cord-007796-zggk0x2q 101 4 the the DT cord-007796-zggk0x2q 101 5 community community NN cord-007796-zggk0x2q 101 6 the the DT cord-007796-zggk0x2q 101 7 whole whole JJ cord-007796-zggk0x2q 101 8 year year NN cord-007796-zggk0x2q 101 9 round round NN cord-007796-zggk0x2q 101 10 , , , cord-007796-zggk0x2q 101 11 rhinovirus rhinovirus NN cord-007796-zggk0x2q 101 12 infections infection NNS cord-007796-zggk0x2q 101 13 peak peak VBP cord-007796-zggk0x2q 101 14 at at IN cord-007796-zggk0x2q 101 15 the the DT cord-007796-zggk0x2q 101 16 onset onset NN cord-007796-zggk0x2q 101 17 of of IN cord-007796-zggk0x2q 101 18 fall fall NN cord-007796-zggk0x2q 101 19 , , , cord-007796-zggk0x2q 101 20 which which WDT cord-007796-zggk0x2q 101 21 is be VBZ cord-007796-zggk0x2q 101 22 probably probably RB cord-007796-zggk0x2q 101 23 related relate VBN cord-007796-zggk0x2q 101 24 to to IN cord-007796-zggk0x2q 101 25 schools school NNS cord-007796-zggk0x2q 101 26 starting start VBG cord-007796-zggk0x2q 101 27 after after IN cord-007796-zggk0x2q 101 28 summer summer NN cord-007796-zggk0x2q 101 29 break break NN cord-007796-zggk0x2q 101 30 . . . cord-007796-zggk0x2q 102 1 Rhinoviruses Rhinoviruses NNP cord-007796-zggk0x2q 102 2 can can MD cord-007796-zggk0x2q 102 3 cause cause VB cord-007796-zggk0x2q 102 4 severe severe JJ cord-007796-zggk0x2q 102 5 lower low JJR cord-007796-zggk0x2q 102 6 respiratory respiratory JJ cord-007796-zggk0x2q 102 7 tract tract NN cord-007796-zggk0x2q 102 8 infection infection NN cord-007796-zggk0x2q 102 9 ( ( -LRB- cord-007796-zggk0x2q 102 10 Guittet Guittet NNP cord-007796-zggk0x2q 102 11 et et FW cord-007796-zggk0x2q 102 12 al al NNP cord-007796-zggk0x2q 102 13 . . NNP cord-007796-zggk0x2q 102 14 , , , cord-007796-zggk0x2q 102 15 2003 2003 CD cord-007796-zggk0x2q 102 16 ; ; : cord-007796-zggk0x2q 102 17 Papadopoulos Papadopoulos NNP cord-007796-zggk0x2q 102 18 , , , cord-007796-zggk0x2q 102 19 2004 2004 CD cord-007796-zggk0x2q 102 20 ) ) -RRB- cord-007796-zggk0x2q 103 1 and and CC cord-007796-zggk0x2q 103 2 in in IN cord-007796-zggk0x2q 103 3 immunocompromised immunocompromised JJ cord-007796-zggk0x2q 103 4 patients patient NNS cord-007796-zggk0x2q 103 5 , , , cord-007796-zggk0x2q 103 6 life life NN cord-007796-zggk0x2q 103 7 - - HYPH cord-007796-zggk0x2q 103 8 threatening threaten VBG cord-007796-zggk0x2q 103 9 pneumonia pneumonia NN cord-007796-zggk0x2q 103 10 . . . cord-007796-zggk0x2q 104 1 Rhinovirus rhinovirus NN cord-007796-zggk0x2q 104 2 is be VBZ cord-007796-zggk0x2q 104 3 a a DT cord-007796-zggk0x2q 104 4 positive positive JJ cord-007796-zggk0x2q 104 5 - - HYPH cord-007796-zggk0x2q 104 6 stranded strand VBN cord-007796-zggk0x2q 104 7 RNA rna NN cord-007796-zggk0x2q 104 8 - - HYPH cord-007796-zggk0x2q 104 9 virus virus NN cord-007796-zggk0x2q 104 10 belonging belong VBG cord-007796-zggk0x2q 104 11 to to IN cord-007796-zggk0x2q 104 12 the the DT cord-007796-zggk0x2q 104 13 Picornavirus Picornavirus NNP cord-007796-zggk0x2q 104 14 family family NN cord-007796-zggk0x2q 104 15 and and CC cord-007796-zggk0x2q 104 16 over over IN cord-007796-zggk0x2q 104 17 100 100 CD cord-007796-zggk0x2q 104 18 serotypes serotype NNS cord-007796-zggk0x2q 104 19 exist exist VBP cord-007796-zggk0x2q 104 20 , , , cord-007796-zggk0x2q 104 21 making make VBG cord-007796-zggk0x2q 104 22 it -PRON- PRP cord-007796-zggk0x2q 104 23 difficult difficult JJ cord-007796-zggk0x2q 104 24 to to TO cord-007796-zggk0x2q 104 25 develop develop VB cord-007796-zggk0x2q 104 26 an an DT cord-007796-zggk0x2q 104 27 effective effective JJ cord-007796-zggk0x2q 104 28 vaccine vaccine NN cord-007796-zggk0x2q 104 29 . . . cord-007796-zggk0x2q 105 1 Rhinovirus rhinovirus NN cord-007796-zggk0x2q 105 2 subtypes subtype NNS cord-007796-zggk0x2q 105 3 have have VBP cord-007796-zggk0x2q 105 4 been be VBN cord-007796-zggk0x2q 105 5 divided divide VBN cord-007796-zggk0x2q 105 6 into into IN cord-007796-zggk0x2q 105 7 a a DT cord-007796-zggk0x2q 105 8 major major JJ cord-007796-zggk0x2q 105 9 and and CC cord-007796-zggk0x2q 105 10 minor minor JJ cord-007796-zggk0x2q 105 11 group group NN cord-007796-zggk0x2q 105 12 with with IN cord-007796-zggk0x2q 105 13 respect respect NN cord-007796-zggk0x2q 105 14 to to IN cord-007796-zggk0x2q 105 15 the the DT cord-007796-zggk0x2q 105 16 receptor receptor NN cord-007796-zggk0x2q 105 17 used use VBN cord-007796-zggk0x2q 105 18 for for IN cord-007796-zggk0x2q 105 19 cell cell NN cord-007796-zggk0x2q 105 20 entry entry NN cord-007796-zggk0x2q 105 21 ( ( -LRB- cord-007796-zggk0x2q 105 22 Table table NN cord-007796-zggk0x2q 105 23 4 4 CD cord-007796-zggk0x2q 105 24 .1 .1 CD cord-007796-zggk0x2q 105 25 ) ) -RRB- cord-007796-zggk0x2q 105 26 . . . cord-007796-zggk0x2q 106 1 Major major JJ cord-007796-zggk0x2q 106 2 group group NN cord-007796-zggk0x2q 106 3 rhinoviruses rhinovirus NNS cord-007796-zggk0x2q 106 4 use use VBP cord-007796-zggk0x2q 106 5 epithelial epithelial JJ cord-007796-zggk0x2q 106 6 intracellular intracellular JJ cord-007796-zggk0x2q 106 7 adhesion adhesion NN cord-007796-zggk0x2q 106 8 molecule molecule NN cord-007796-zggk0x2q 106 9 l l NN cord-007796-zggk0x2q 106 10 ( ( -LRB- cord-007796-zggk0x2q 106 11 ICAM-1 ICAM-1 NNP cord-007796-zggk0x2q 106 12 ) ) -RRB- cord-007796-zggk0x2q 106 13 for for IN cord-007796-zggk0x2q 106 14 cell cell NN cord-007796-zggk0x2q 106 15 entry entry NN cord-007796-zggk0x2q 106 16 , , , cord-007796-zggk0x2q 106 17 while while IN cord-007796-zggk0x2q 106 18 minor minor JJ cord-007796-zggk0x2q 106 19 group group NN cord-007796-zggk0x2q 106 20 viruses virus NNS cord-007796-zggk0x2q 106 21 bind bind VBP cord-007796-zggk0x2q 106 22 to to IN cord-007796-zggk0x2q 106 23 the the DT cord-007796-zggk0x2q 106 24 low low JJ cord-007796-zggk0x2q 106 25 - - HYPH cord-007796-zggk0x2q 106 26 density density NN cord-007796-zggk0x2q 106 27 lipoprotein lipoprotein NN cord-007796-zggk0x2q 106 28 ( ( -LRB- cord-007796-zggk0x2q 106 29 LDL LDL NNP cord-007796-zggk0x2q 106 30 ) ) -RRB- cord-007796-zggk0x2q 106 31 receptor receptor NN cord-007796-zggk0x2q 106 32 . . . cord-007796-zggk0x2q 107 1 During during IN cord-007796-zggk0x2q 107 2 rhinovirus rhinovirus NN cord-007796-zggk0x2q 107 3 infection infection NN cord-007796-zggk0x2q 107 4 , , , cord-007796-zggk0x2q 107 5 a a DT cord-007796-zggk0x2q 107 6 predominant predominant JJ cord-007796-zggk0x2q 107 7 granulocyte granulocyte NN cord-007796-zggk0x2q 107 8 and and CC cord-007796-zggk0x2q 107 9 monocyte monocyte NNP cord-007796-zggk0x2q 107 10 recruitments recruitment NNS cord-007796-zggk0x2q 107 11 are be VBP cord-007796-zggk0x2q 107 12 observed observe VBN cord-007796-zggk0x2q 107 13 . . . cord-007796-zggk0x2q 108 1 While while IN cord-007796-zggk0x2q 108 2 specific specific JJ cord-007796-zggk0x2q 108 3 antibody antibody NN cord-007796-zggk0x2q 108 4 production production NN cord-007796-zggk0x2q 108 5 occurs occur VBZ cord-007796-zggk0x2q 108 6 , , , cord-007796-zggk0x2q 108 7 it -PRON- PRP cord-007796-zggk0x2q 108 8 is be VBZ cord-007796-zggk0x2q 108 9 probably probably RB cord-007796-zggk0x2q 108 10 not not RB cord-007796-zggk0x2q 108 11 required require VBN cord-007796-zggk0x2q 108 12 for for IN cord-007796-zggk0x2q 108 13 viral viral JJ cord-007796-zggk0x2q 108 14 clearance clearance NN cord-007796-zggk0x2q 108 15 , , , cord-007796-zggk0x2q 108 16 although although IN cord-007796-zggk0x2q 108 17 neutralizing neutralize VBG cord-007796-zggk0x2q 108 18 antibodies antibody NNS cord-007796-zggk0x2q 108 19 can can MD cord-007796-zggk0x2q 108 20 provide provide VB cord-007796-zggk0x2q 108 21 some some DT cord-007796-zggk0x2q 108 22 temporary temporary JJ cord-007796-zggk0x2q 108 23 protection protection NN cord-007796-zggk0x2q 108 24 against against IN cord-007796-zggk0x2q 108 25 rhinovirus rhinovirus NN cord-007796-zggk0x2q 108 26 reinfection reinfection NN cord-007796-zggk0x2q 108 27 ( ( -LRB- cord-007796-zggk0x2q 108 28 van van NNP cord-007796-zggk0x2q 108 29 Kempen Kempen NNP cord-007796-zggk0x2q 108 30 et et NNP cord-007796-zggk0x2q 108 31 al al NNP cord-007796-zggk0x2q 108 32 . . NNP cord-007796-zggk0x2q 108 33 , , , cord-007796-zggk0x2q 108 34 1999 1999 CD cord-007796-zggk0x2q 108 35 ) ) -RRB- cord-007796-zggk0x2q 108 36 . . . cord-007796-zggk0x2q 109 1 ICAM-1 ICAM-1 NNP cord-007796-zggk0x2q 109 2 blocking block VBG cord-007796-zggk0x2q 109 3 antibodies antibody NNS cord-007796-zggk0x2q 109 4 have have VBP cord-007796-zggk0x2q 109 5 also also RB cord-007796-zggk0x2q 109 6 been be VBN cord-007796-zggk0x2q 109 7 utilized utilize VBN cord-007796-zggk0x2q 109 8 and and CC cord-007796-zggk0x2q 109 9 have have VBP cord-007796-zggk0x2q 109 10 been be VBN cord-007796-zggk0x2q 109 11 shown show VBN cord-007796-zggk0x2q 109 12 to to TO cord-007796-zggk0x2q 109 13 decrease decrease VB cord-007796-zggk0x2q 109 14 inflammation inflammation NN cord-007796-zggk0x2q 109 15 in in IN cord-007796-zggk0x2q 109 16 vitro vitro FW cord-007796-zggk0x2q 109 17 . . . cord-007796-zggk0x2q 110 1 There there EX cord-007796-zggk0x2q 110 2 are be VBP cord-007796-zggk0x2q 110 3 , , , cord-007796-zggk0x2q 110 4 however however RB cord-007796-zggk0x2q 110 5 , , , cord-007796-zggk0x2q 110 6 indications indication NNS cord-007796-zggk0x2q 110 7 that that IN cord-007796-zggk0x2q 110 8 rhinovirus rhinovirus NN cord-007796-zggk0x2q 110 9 can can MD cord-007796-zggk0x2q 110 10 adapt adapt VB cord-007796-zggk0x2q 110 11 to to IN cord-007796-zggk0x2q 110 12 this this DT cord-007796-zggk0x2q 110 13 with with IN cord-007796-zggk0x2q 110 14 changes change NNS cord-007796-zggk0x2q 110 15 in in IN cord-007796-zggk0x2q 110 16 receptor receptor NN cord-007796-zggk0x2q 110 17 usage usage NN cord-007796-zggk0x2q 111 1 ( ( -LRB- cord-007796-zggk0x2q 111 2 Reischl Reischl NNP cord-007796-zggk0x2q 111 3 et et FW cord-007796-zggk0x2q 111 4 al al NNP cord-007796-zggk0x2q 111 5 . . NNP cord-007796-zggk0x2q 111 6 , , , cord-007796-zggk0x2q 111 7 2001 2001 CD cord-007796-zggk0x2q 111 8 ) ) -RRB- cord-007796-zggk0x2q 111 9 . . . cord-007796-zggk0x2q 112 1 In in IN cord-007796-zggk0x2q 112 2 2001 2001 CD cord-007796-zggk0x2q 112 3 , , , cord-007796-zggk0x2q 112 4 a a DT cord-007796-zggk0x2q 112 5 new new JJ cord-007796-zggk0x2q 112 6 respiratory respiratory JJ cord-007796-zggk0x2q 112 7 virus virus NN cord-007796-zggk0x2q 112 8 was be VBD cord-007796-zggk0x2q 112 9 identified identify VBN cord-007796-zggk0x2q 112 10 in in IN cord-007796-zggk0x2q 112 11 the the DT cord-007796-zggk0x2q 112 12 Netherlands Netherlands NNP cord-007796-zggk0x2q 112 13 causing cause VBG cord-007796-zggk0x2q 112 14 infections infection NNS cord-007796-zggk0x2q 112 15 similar similar JJ cord-007796-zggk0x2q 112 16 to to IN cord-007796-zggk0x2q 112 17 RSV RSV NNP cord-007796-zggk0x2q 112 18 in in IN cord-007796-zggk0x2q 112 19 children child NNS cord-007796-zggk0x2q 112 20 ( ( -LRB- cord-007796-zggk0x2q 112 21 van van NNP cord-007796-zggk0x2q 112 22 den den NNP cord-007796-zggk0x2q 112 23 Hoogen Hoogen NNP cord-007796-zggk0x2q 112 24 et et NNP cord-007796-zggk0x2q 112 25 al al NNP cord-007796-zggk0x2q 112 26 . . NNP cord-007796-zggk0x2q 112 27 , , , cord-007796-zggk0x2q 112 28 2001 2001 CD cord-007796-zggk0x2q 112 29 ) ) -RRB- cord-007796-zggk0x2q 112 30 . . . cord-007796-zggk0x2q 113 1 The the DT cord-007796-zggk0x2q 113 2 reported report VBN cord-007796-zggk0x2q 113 3 incidence incidence NN cord-007796-zggk0x2q 113 4 rate rate NN cord-007796-zggk0x2q 113 5 of of IN cord-007796-zggk0x2q 113 6 human human NN cord-007796-zggk0x2q 113 7 metapneumovirus metapneumovirus NNP cord-007796-zggk0x2q 113 8 ( ( -LRB- cord-007796-zggk0x2q 113 9 hMPV hmpv NN cord-007796-zggk0x2q 113 10 ) ) -RRB- cord-007796-zggk0x2q 113 11 infection infection NN cord-007796-zggk0x2q 113 12 in in IN cord-007796-zggk0x2q 113 13 children child NNS cord-007796-zggk0x2q 113 14 with with IN cord-007796-zggk0x2q 113 15 acute acute JJ cord-007796-zggk0x2q 113 16 respiratory respiratory JJ cord-007796-zggk0x2q 113 17 symptoms symptom NNS cord-007796-zggk0x2q 113 18 varies vary VBZ cord-007796-zggk0x2q 113 19 between between IN cord-007796-zggk0x2q 113 20 4 4 CD cord-007796-zggk0x2q 113 21 % % NN cord-007796-zggk0x2q 113 22 and and CC cord-007796-zggk0x2q 113 23 16 16 CD cord-007796-zggk0x2q 113 24 % % NN cord-007796-zggk0x2q 113 25 , , , cord-007796-zggk0x2q 113 26 of of IN cord-007796-zggk0x2q 113 27 which which WDT cord-007796-zggk0x2q 113 28 three three CD cord-007796-zggk0x2q 113 29 - - HYPH cord-007796-zggk0x2q 113 30 quarters quarter NNS cord-007796-zggk0x2q 113 31 occur occur VBP cord-007796-zggk0x2q 113 32 in in IN cord-007796-zggk0x2q 113 33 children child NNS cord-007796-zggk0x2q 113 34 less less JJR cord-007796-zggk0x2q 113 35 than than IN cord-007796-zggk0x2q 113 36 1-year 1-year CD cord-007796-zggk0x2q 113 37 old old JJ cord-007796-zggk0x2q 114 1 ( ( -LRB- cord-007796-zggk0x2q 114 2 Williams Williams NNP cord-007796-zggk0x2q 114 3 et et NNP cord-007796-zggk0x2q 114 4 al al NNP cord-007796-zggk0x2q 114 5 . . NNP cord-007796-zggk0x2q 114 6 , , , cord-007796-zggk0x2q 114 7 2004 2004 CD cord-007796-zggk0x2q 114 8 ) ) -RRB- cord-007796-zggk0x2q 114 9 . . . cord-007796-zggk0x2q 115 1 By by IN cord-007796-zggk0x2q 115 2 the the DT cord-007796-zggk0x2q 115 3 age age NN cord-007796-zggk0x2q 115 4 of of IN cord-007796-zggk0x2q 115 5 5 5 CD cord-007796-zggk0x2q 115 6 years year NNS cord-007796-zggk0x2q 115 7 , , , cord-007796-zggk0x2q 115 8 approximately approximately RB cord-007796-zggk0x2q 115 9 70 70 CD cord-007796-zggk0x2q 115 10 % % NN cord-007796-zggk0x2q 115 11 of of IN cord-007796-zggk0x2q 115 12 children child NNS cord-007796-zggk0x2q 115 13 have have VBP cord-007796-zggk0x2q 115 14 developed develop VBN cord-007796-zggk0x2q 115 15 antibodies antibody NNS cord-007796-zggk0x2q 115 16 to to TO cord-007796-zggk0x2q 115 17 hMPV hmpv VB cord-007796-zggk0x2q 115 18 . . . cord-007796-zggk0x2q 116 1 HMPV HMPV NNP cord-007796-zggk0x2q 116 2 very very RB cord-007796-zggk0x2q 116 3 much much RB cord-007796-zggk0x2q 116 4 resembles resemble VBZ cord-007796-zggk0x2q 116 5 RSV RSV NNP cord-007796-zggk0x2q 116 6 in in IN cord-007796-zggk0x2q 116 7 its -PRON- PRP$ cord-007796-zggk0x2q 116 8 clinical clinical JJ cord-007796-zggk0x2q 116 9 spectrum spectrum NN cord-007796-zggk0x2q 116 10 , , , cord-007796-zggk0x2q 116 11 varying vary VBG cord-007796-zggk0x2q 116 12 from from IN cord-007796-zggk0x2q 116 13 coryza coryza NNP cord-007796-zggk0x2q 116 14 to to IN cord-007796-zggk0x2q 116 15 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 116 16 and and CC cord-007796-zggk0x2q 116 17 pneumonia pneumonia NN cord-007796-zggk0x2q 116 18 . . . cord-007796-zggk0x2q 117 1 However however RB cord-007796-zggk0x2q 117 2 , , , cord-007796-zggk0x2q 117 3 hMPV hmpv NN cord-007796-zggk0x2q 117 4 is be VBZ cord-007796-zggk0x2q 117 5 less less RBR cord-007796-zggk0x2q 117 6 likely likely JJ cord-007796-zggk0x2q 117 7 to to TO cord-007796-zggk0x2q 117 8 cause cause VB cord-007796-zggk0x2q 117 9 pneumonia pneumonia NN cord-007796-zggk0x2q 117 10 than than IN cord-007796-zggk0x2q 117 11 RSV RSV NNP cord-007796-zggk0x2q 117 12 and and CC cord-007796-zggk0x2q 117 13 influenza influenza NN cord-007796-zggk0x2q 117 14 virus virus NN cord-007796-zggk0x2q 117 15 . . . cord-007796-zggk0x2q 118 1 Children child NNS cord-007796-zggk0x2q 118 2 with with IN cord-007796-zggk0x2q 118 3 hMPV hmpv NN cord-007796-zggk0x2q 118 4 infection infection NN cord-007796-zggk0x2q 118 5 present present JJ cord-007796-zggk0x2q 118 6 less less RBR cord-007796-zggk0x2q 118 7 frequently frequently RB cord-007796-zggk0x2q 118 8 with with IN cord-007796-zggk0x2q 118 9 atypical atypical JJ cord-007796-zggk0x2q 118 10 symptoms symptom NNS cord-007796-zggk0x2q 118 11 such such JJ cord-007796-zggk0x2q 118 12 as as IN cord-007796-zggk0x2q 118 13 vomiting vomiting NN cord-007796-zggk0x2q 118 14 , , , cord-007796-zggk0x2q 118 15 and and CC cord-007796-zggk0x2q 118 16 on on IN cord-007796-zggk0x2q 118 17 physical physical JJ cord-007796-zggk0x2q 118 18 examination examination NN cord-007796-zggk0x2q 118 19 , , , cord-007796-zggk0x2q 118 20 rales rale NNS cord-007796-zggk0x2q 118 21 and and CC cord-007796-zggk0x2q 118 22 wheezing wheezing NN cord-007796-zggk0x2q 118 23 are be VBP cord-007796-zggk0x2q 118 24 found find VBN cord-007796-zggk0x2q 118 25 less less RBR cord-007796-zggk0x2q 118 26 often often RB cord-007796-zggk0x2q 118 27 . . . cord-007796-zggk0x2q 119 1 Co co NN cord-007796-zggk0x2q 119 2 - - NN cord-007796-zggk0x2q 119 3 infection infection NN cord-007796-zggk0x2q 119 4 with with IN cord-007796-zggk0x2q 119 5 RSV RSV NNP cord-007796-zggk0x2q 119 6 and and CC cord-007796-zggk0x2q 119 7 hMPV hmpv NN cord-007796-zggk0x2q 119 8 does do VBZ cord-007796-zggk0x2q 119 9 occur occur VB cord-007796-zggk0x2q 119 10 and and CC cord-007796-zggk0x2q 119 11 has have VBZ cord-007796-zggk0x2q 119 12 been be VBN cord-007796-zggk0x2q 119 13 suggested suggest VBN cord-007796-zggk0x2q 119 14 to to TO cord-007796-zggk0x2q 119 15 result result VB cord-007796-zggk0x2q 119 16 in in IN cord-007796-zggk0x2q 119 17 more more JJR cord-007796-zggk0x2q 119 18 severe severe JJ cord-007796-zggk0x2q 119 19 disease disease NN cord-007796-zggk0x2q 119 20 ( ( -LRB- cord-007796-zggk0x2q 119 21 Greensill Greensill NNP cord-007796-zggk0x2q 119 22 et et NNP cord-007796-zggk0x2q 119 23 al al NNP cord-007796-zggk0x2q 119 24 . . NNP cord-007796-zggk0x2q 119 25 , , , cord-007796-zggk0x2q 119 26 2003 2003 CD cord-007796-zggk0x2q 119 27 ) ) -RRB- cord-007796-zggk0x2q 119 28 . . . cord-007796-zggk0x2q 120 1 There there EX cord-007796-zggk0x2q 120 2 is be VBZ cord-007796-zggk0x2q 120 3 some some DT cord-007796-zggk0x2q 120 4 evidence evidence NN cord-007796-zggk0x2q 120 5 that that IN cord-007796-zggk0x2q 120 6 secondary secondary JJ cord-007796-zggk0x2q 120 7 hMPV hmpv NN cord-007796-zggk0x2q 120 8 infection infection NN cord-007796-zggk0x2q 120 9 occurs occur VBZ cord-007796-zggk0x2q 120 10 frequently frequently RB cord-007796-zggk0x2q 120 11 in in IN cord-007796-zggk0x2q 120 12 childhood childhood NN cord-007796-zggk0x2q 120 13 , , , cord-007796-zggk0x2q 120 14 probably probably RB cord-007796-zggk0x2q 120 15 accompanied accompany VBN cord-007796-zggk0x2q 120 16 only only RB cord-007796-zggk0x2q 120 17 by by IN cord-007796-zggk0x2q 120 18 mild mild JJ cord-007796-zggk0x2q 120 19 symptoms symptom NNS cord-007796-zggk0x2q 120 20 ( ( -LRB- cord-007796-zggk0x2q 121 1 Ebihara Ebihara NNP cord-007796-zggk0x2q 121 2 et et FW cord-007796-zggk0x2q 121 3 al al NNP cord-007796-zggk0x2q 121 4 . . . cord-007796-zggk0x2q 122 1 , , , cord-007796-zggk0x2q 122 2 2004 2004 CD cord-007796-zggk0x2q 122 3 ) ) -RRB- cord-007796-zggk0x2q 122 4 . . . cord-007796-zggk0x2q 123 1 Several several JJ cord-007796-zggk0x2q 123 2 investigators investigator NNS cord-007796-zggk0x2q 123 3 have have VBP cord-007796-zggk0x2q 123 4 found find VBN cord-007796-zggk0x2q 123 5 chemokine chemokine NN cord-007796-zggk0x2q 123 6 profiles profile NNS cord-007796-zggk0x2q 123 7 during during IN cord-007796-zggk0x2q 123 8 acute acute JJ cord-007796-zggk0x2q 123 9 infection infection NN cord-007796-zggk0x2q 123 10 to to TO cord-007796-zggk0x2q 123 11 be be VB cord-007796-zggk0x2q 123 12 different different JJ cord-007796-zggk0x2q 123 13 in in IN cord-007796-zggk0x2q 123 14 children child NNS cord-007796-zggk0x2q 123 15 with with IN cord-007796-zggk0x2q 123 16 hMPV hmpv NN cord-007796-zggk0x2q 123 17 infections infection NNS cord-007796-zggk0x2q 123 18 compared compare VBN cord-007796-zggk0x2q 123 19 to to IN cord-007796-zggk0x2q 123 20 those those DT cord-007796-zggk0x2q 123 21 with with IN cord-007796-zggk0x2q 123 22 RSV RSV NNP cord-007796-zggk0x2q 123 23 infections infection NNS cord-007796-zggk0x2q 123 24 , , , cord-007796-zggk0x2q 123 25 with with IN cord-007796-zggk0x2q 123 26 higher high JJR cord-007796-zggk0x2q 123 27 interleukin-8 interleukin-8 NNP cord-007796-zggk0x2q 123 28 ( ( -LRB- cord-007796-zggk0x2q 123 29 IL-8 il-8 NN cord-007796-zggk0x2q 123 30 ) ) -RRB- cord-007796-zggk0x2q 123 31 and and CC cord-007796-zggk0x2q 123 32 lower low JJR cord-007796-zggk0x2q 123 33 RANTES rante NNS cord-007796-zggk0x2q 123 34 concentrations concentration NNS cord-007796-zggk0x2q 123 35 in in IN cord-007796-zggk0x2q 123 36 hMPV hmpv NN cord-007796-zggk0x2q 123 37 patients patient NNS cord-007796-zggk0x2q 123 38 . . . cord-007796-zggk0x2q 124 1 However however RB cord-007796-zggk0x2q 124 2 in in IN cord-007796-zggk0x2q 124 3 another another DT cord-007796-zggk0x2q 124 4 study study NN cord-007796-zggk0x2q 124 5 , , , cord-007796-zggk0x2q 124 6 inflammatory inflammatory JJ cord-007796-zggk0x2q 124 7 cytokine cytokine NN cord-007796-zggk0x2q 124 8 ( ( -LRB- cord-007796-zggk0x2q 124 9 IL-8 IL-8 NNP cord-007796-zggk0x2q 124 10 , , , cord-007796-zggk0x2q 124 11 TNF- TNF- NNP cord-007796-zggk0x2q 124 12 ␣ ␣ NN cord-007796-zggk0x2q 124 13 , , , cord-007796-zggk0x2q 124 14 IL-1 IL-1 NNP cord-007796-zggk0x2q 124 15 ␤ ␤ NNP cord-007796-zggk0x2q 124 16 ) ) -RRB- cord-007796-zggk0x2q 124 17 levels level NNS cord-007796-zggk0x2q 124 18 in in IN cord-007796-zggk0x2q 124 19 respiratory respiratory JJ cord-007796-zggk0x2q 124 20 secretions secretion NNS cord-007796-zggk0x2q 124 21 were be VBD cord-007796-zggk0x2q 124 22 6-fold 6-fold CD cord-007796-zggk0x2q 124 23 lower low JJR cord-007796-zggk0x2q 124 24 than than IN cord-007796-zggk0x2q 124 25 in in IN cord-007796-zggk0x2q 124 26 children child NNS cord-007796-zggk0x2q 124 27 infected infect VBN cord-007796-zggk0x2q 124 28 with with IN cord-007796-zggk0x2q 124 29 RSV RSV NNP cord-007796-zggk0x2q 124 30 ( ( -LRB- cord-007796-zggk0x2q 124 31 Jartti Jartti NNP cord-007796-zggk0x2q 124 32 et et NNP cord-007796-zggk0x2q 124 33 al al NNP cord-007796-zggk0x2q 124 34 . . NNP cord-007796-zggk0x2q 124 35 , , , cord-007796-zggk0x2q 124 36 2002 2002 CD cord-007796-zggk0x2q 124 37 ; ; : cord-007796-zggk0x2q 125 1 Laham Laham NNP cord-007796-zggk0x2q 125 2 et et NNP cord-007796-zggk0x2q 125 3 al al NNP cord-007796-zggk0x2q 125 4 . . NNP cord-007796-zggk0x2q 125 5 , , , cord-007796-zggk0x2q 125 6 2004 2004 CD cord-007796-zggk0x2q 125 7 ) ) -RRB- cord-007796-zggk0x2q 125 8 . . . cord-007796-zggk0x2q 126 1 Tthe tthe DT cord-007796-zggk0x2q 126 2 physiological physiological JJ cord-007796-zggk0x2q 126 3 relevance relevance NN cord-007796-zggk0x2q 126 4 of of IN cord-007796-zggk0x2q 126 5 these these DT cord-007796-zggk0x2q 126 6 observations observation NNS cord-007796-zggk0x2q 126 7 remains remain VBZ cord-007796-zggk0x2q 126 8 unclear unclear JJ cord-007796-zggk0x2q 126 9 . . . cord-007796-zggk0x2q 127 1 The the DT cord-007796-zggk0x2q 127 2 outbreak outbreak NN cord-007796-zggk0x2q 127 3 of of IN cord-007796-zggk0x2q 127 4 Severe severe JJ cord-007796-zggk0x2q 127 5 Acute acute JJ cord-007796-zggk0x2q 127 6 Respiratory respiratory JJ cord-007796-zggk0x2q 127 7 Distress Distress NNP cord-007796-zggk0x2q 127 8 Syndrome Syndrome NNP cord-007796-zggk0x2q 127 9 ( ( -LRB- cord-007796-zggk0x2q 127 10 SARS SARS NNP cord-007796-zggk0x2q 127 11 ) ) -RRB- cord-007796-zggk0x2q 127 12 , , , cord-007796-zggk0x2q 127 13 which which WDT cord-007796-zggk0x2q 127 14 started start VBD cord-007796-zggk0x2q 127 15 in in IN cord-007796-zggk0x2q 127 16 late late JJ cord-007796-zggk0x2q 127 17 2002 2002 CD cord-007796-zggk0x2q 127 18 in in IN cord-007796-zggk0x2q 127 19 East East NNP cord-007796-zggk0x2q 127 20 Asia Asia NNP cord-007796-zggk0x2q 127 21 , , , cord-007796-zggk0x2q 127 22 and and CC cord-007796-zggk0x2q 127 23 spread spread VBD cord-007796-zggk0x2q 127 24 throughout throughout IN cord-007796-zggk0x2q 127 25 the the DT cord-007796-zggk0x2q 127 26 world world NN cord-007796-zggk0x2q 127 27 during during IN cord-007796-zggk0x2q 127 28 that that DT cord-007796-zggk0x2q 127 29 winter winter NN cord-007796-zggk0x2q 127 30 , , , cord-007796-zggk0x2q 127 31 was be VBD cord-007796-zggk0x2q 127 32 found find VBN cord-007796-zggk0x2q 127 33 to to TO cord-007796-zggk0x2q 127 34 affect affect VB cord-007796-zggk0x2q 127 35 mainly mainly RB cord-007796-zggk0x2q 127 36 health health NN cord-007796-zggk0x2q 127 37 - - HYPH cord-007796-zggk0x2q 127 38 care care NN cord-007796-zggk0x2q 127 39 workers worker NNS cord-007796-zggk0x2q 127 40 and and CC cord-007796-zggk0x2q 127 41 close close JJ cord-007796-zggk0x2q 127 42 contacts contact NNS cord-007796-zggk0x2q 127 43 of of IN cord-007796-zggk0x2q 127 44 diseased diseased JJ cord-007796-zggk0x2q 127 45 individuals individual NNS cord-007796-zggk0x2q 127 46 . . . cord-007796-zggk0x2q 128 1 SARS SARS NNP cord-007796-zggk0x2q 128 2 , , , cord-007796-zggk0x2q 128 3 which which WDT cord-007796-zggk0x2q 128 4 was be VBD cord-007796-zggk0x2q 128 5 proved prove VBN cord-007796-zggk0x2q 128 6 to to TO cord-007796-zggk0x2q 128 7 be be VB cord-007796-zggk0x2q 128 8 caused cause VBN cord-007796-zggk0x2q 128 9 by by IN cord-007796-zggk0x2q 128 10 a a DT cord-007796-zggk0x2q 128 11 new new JJ cord-007796-zggk0x2q 128 12 coronavirus coronavirus NN cord-007796-zggk0x2q 128 13 , , , cord-007796-zggk0x2q 128 14 induces induce VBZ cord-007796-zggk0x2q 128 15 an an DT cord-007796-zggk0x2q 128 16 atypical atypical JJ cord-007796-zggk0x2q 128 17 pneumonia pneumonia NN cord-007796-zggk0x2q 128 18 with with IN cord-007796-zggk0x2q 128 19 fever fever NN cord-007796-zggk0x2q 128 20 , , , cord-007796-zggk0x2q 128 21 dry dry JJ cord-007796-zggk0x2q 128 22 cough cough NN cord-007796-zggk0x2q 128 23 , , , cord-007796-zggk0x2q 128 24 and and CC cord-007796-zggk0x2q 128 25 shortness shortness NN cord-007796-zggk0x2q 128 26 of of IN cord-007796-zggk0x2q 128 27 breath breath NN cord-007796-zggk0x2q 128 28 . . . cord-007796-zggk0x2q 129 1 Many many JJ cord-007796-zggk0x2q 129 2 adults adult NNS cord-007796-zggk0x2q 129 3 also also RB cord-007796-zggk0x2q 129 4 suffer suffer VBP cord-007796-zggk0x2q 129 5 from from IN cord-007796-zggk0x2q 129 6 myalgia myalgia NN cord-007796-zggk0x2q 129 7 , , , cord-007796-zggk0x2q 129 8 dizziness dizziness NN cord-007796-zggk0x2q 129 9 , , , cord-007796-zggk0x2q 129 10 chills chill NNS cord-007796-zggk0x2q 129 11 , , , cord-007796-zggk0x2q 129 12 and and CC cord-007796-zggk0x2q 129 13 rigors rigor NNS cord-007796-zggk0x2q 129 14 . . . cord-007796-zggk0x2q 130 1 It -PRON- PRP cord-007796-zggk0x2q 130 2 was be VBD cord-007796-zggk0x2q 130 3 concluded conclude VBN cord-007796-zggk0x2q 130 4 from from IN cord-007796-zggk0x2q 130 5 postmortem postmortem JJ cord-007796-zggk0x2q 130 6 examinations examination NNS cord-007796-zggk0x2q 130 7 that that IN cord-007796-zggk0x2q 130 8 SARS SARS NNP cord-007796-zggk0x2q 130 9 - - HYPH cord-007796-zggk0x2q 130 10 pathology pathology NN cord-007796-zggk0x2q 130 11 is be VBZ cord-007796-zggk0x2q 130 12 primarily primarily RB cord-007796-zggk0x2q 130 13 caused cause VBN cord-007796-zggk0x2q 130 14 by by IN cord-007796-zggk0x2q 130 15 immunological immunological JJ cord-007796-zggk0x2q 130 16 damage damage NN cord-007796-zggk0x2q 130 17 to to IN cord-007796-zggk0x2q 130 18 the the DT cord-007796-zggk0x2q 130 19 lungs lung NNS cord-007796-zggk0x2q 130 20 . . . cord-007796-zggk0x2q 131 1 The the DT cord-007796-zggk0x2q 131 2 interstitial interstitial JJ cord-007796-zggk0x2q 131 3 space space NN cord-007796-zggk0x2q 131 4 of of IN cord-007796-zggk0x2q 131 5 the the DT cord-007796-zggk0x2q 131 6 lungs lung NNS cord-007796-zggk0x2q 131 7 was be VBD cord-007796-zggk0x2q 131 8 mainly mainly RB cord-007796-zggk0x2q 131 9 filled fill VBN cord-007796-zggk0x2q 131 10 with with IN cord-007796-zggk0x2q 131 11 mononuclear mononuclear JJ cord-007796-zggk0x2q 131 12 infiltrates infiltrate NNS cord-007796-zggk0x2q 131 13 and and CC cord-007796-zggk0x2q 131 14 there there EX cord-007796-zggk0x2q 131 15 was be VBD cord-007796-zggk0x2q 131 16 diffuse diffuse JJ cord-007796-zggk0x2q 131 17 hemorrhage hemorrhage NN cord-007796-zggk0x2q 131 18 on on IN cord-007796-zggk0x2q 131 19 the the DT cord-007796-zggk0x2q 131 20 lung lung NN cord-007796-zggk0x2q 131 21 surface surface NN cord-007796-zggk0x2q 131 22 . . . cord-007796-zggk0x2q 132 1 SARS SARS NNP cord-007796-zggk0x2q 132 2 coronavirus coronavirus NN cord-007796-zggk0x2q 132 3 ( ( -LRB- cord-007796-zggk0x2q 132 4 SARS SARS NNP cord-007796-zggk0x2q 132 5 - - HYPH cord-007796-zggk0x2q 132 6 CoV CoV NNP cord-007796-zggk0x2q 132 7 ) ) -RRB- cord-007796-zggk0x2q 132 8 spreads spread VBZ cord-007796-zggk0x2q 132 9 mainly mainly RB cord-007796-zggk0x2q 132 10 via via IN cord-007796-zggk0x2q 132 11 the the DT cord-007796-zggk0x2q 132 12 respiratory respiratory JJ cord-007796-zggk0x2q 132 13 route route NN cord-007796-zggk0x2q 132 14 , , , cord-007796-zggk0x2q 132 15 the the DT cord-007796-zggk0x2q 132 16 epithelial epithelial JJ cord-007796-zggk0x2q 132 17 cell cell NN cord-007796-zggk0x2q 132 18 being be VBG cord-007796-zggk0x2q 132 19 its -PRON- PRP$ cord-007796-zggk0x2q 132 20 primary primary JJ cord-007796-zggk0x2q 132 21 target target NN cord-007796-zggk0x2q 132 22 cell cell NN cord-007796-zggk0x2q 132 23 . . . cord-007796-zggk0x2q 133 1 As as IN cord-007796-zggk0x2q 133 2 for for IN cord-007796-zggk0x2q 133 3 other other JJ cord-007796-zggk0x2q 133 4 coronaviruses coronaviruse NNS cord-007796-zggk0x2q 133 5 , , , cord-007796-zggk0x2q 133 6 the the DT cord-007796-zggk0x2q 133 7 spike spike NN cord-007796-zggk0x2q 133 8 proteins protein NNS cord-007796-zggk0x2q 133 9 , , , cord-007796-zggk0x2q 133 10 S1 s1 NN cord-007796-zggk0x2q 133 11 for for IN cord-007796-zggk0x2q 133 12 cell cell NN cord-007796-zggk0x2q 133 13 entry entry NN cord-007796-zggk0x2q 133 14 and and CC cord-007796-zggk0x2q 133 15 S2 s2 NN cord-007796-zggk0x2q 133 16 for for IN cord-007796-zggk0x2q 133 17 fusion fusion NN cord-007796-zggk0x2q 133 18 , , , cord-007796-zggk0x2q 133 19 also also RB cord-007796-zggk0x2q 133 20 seem seem VBP cord-007796-zggk0x2q 133 21 to to TO cord-007796-zggk0x2q 133 22 be be VB cord-007796-zggk0x2q 133 23 important important JJ cord-007796-zggk0x2q 133 24 for for IN cord-007796-zggk0x2q 133 25 SARS SARS NNP cord-007796-zggk0x2q 133 26 entry entry NN cord-007796-zggk0x2q 133 27 of of IN cord-007796-zggk0x2q 133 28 host host NN cord-007796-zggk0x2q 133 29 cells cell NNS cord-007796-zggk0x2q 133 30 , , , cord-007796-zggk0x2q 133 31 despite despite IN cord-007796-zggk0x2q 133 32 the the DT cord-007796-zggk0x2q 133 33 fact fact NN cord-007796-zggk0x2q 133 34 that that IN cord-007796-zggk0x2q 133 35 SARS SARS NNP cord-007796-zggk0x2q 133 36 is be VBZ cord-007796-zggk0x2q 133 37 only only RB cord-007796-zggk0x2q 133 38 20 20 CD cord-007796-zggk0x2q 133 39 - - SYM cord-007796-zggk0x2q 133 40 30 30 CD cord-007796-zggk0x2q 133 41 % % NN cord-007796-zggk0x2q 133 42 homologous homologous JJ cord-007796-zggk0x2q 133 43 to to IN cord-007796-zggk0x2q 133 44 other other JJ cord-007796-zggk0x2q 133 45 coronaviruses coronaviruse NNS cord-007796-zggk0x2q 133 46 . . . cord-007796-zggk0x2q 134 1 Very very RB cord-007796-zggk0x2q 134 2 recently recently RB cord-007796-zggk0x2q 134 3 , , , cord-007796-zggk0x2q 134 4 angiotensine angiotensine NNP cord-007796-zggk0x2q 134 5 converting convert VBG cord-007796-zggk0x2q 134 6 enzyme enzyme NN cord-007796-zggk0x2q 134 7 ( ( -LRB- cord-007796-zggk0x2q 134 8 ACE2 ACE2 NNP cord-007796-zggk0x2q 134 9 ) ) -RRB- cord-007796-zggk0x2q 134 10 was be VBD cord-007796-zggk0x2q 134 11 identified identify VBN cord-007796-zggk0x2q 134 12 as as IN cord-007796-zggk0x2q 134 13 the the DT cord-007796-zggk0x2q 134 14 host host NN cord-007796-zggk0x2q 134 15 cell cell NN cord-007796-zggk0x2q 134 16 receptor receptor NN cord-007796-zggk0x2q 134 17 for for IN cord-007796-zggk0x2q 134 18 SARS SARS NNP cord-007796-zggk0x2q 134 19 - - HYPH cord-007796-zggk0x2q 134 20 CoV CoV NNP cord-007796-zggk0x2q 134 21 ( ( -LRB- cord-007796-zggk0x2q 134 22 Li Li NNP cord-007796-zggk0x2q 134 23 et et NNP cord-007796-zggk0x2q 134 24 al al NNP cord-007796-zggk0x2q 134 25 . . NNP cord-007796-zggk0x2q 134 26 , , , cord-007796-zggk0x2q 134 27 2003 2003 CD cord-007796-zggk0x2q 134 28 ) ) -RRB- cord-007796-zggk0x2q 134 29 and and CC cord-007796-zggk0x2q 134 30 surface surface NN cord-007796-zggk0x2q 134 31 expression expression NN cord-007796-zggk0x2q 134 32 of of IN cord-007796-zggk0x2q 134 33 ACE2 ACE2 NNP cord-007796-zggk0x2q 134 34 on on IN cord-007796-zggk0x2q 134 35 alveolar alveolar JJ cord-007796-zggk0x2q 134 36 epithelial epithelial JJ cord-007796-zggk0x2q 134 37 cells cell NNS cord-007796-zggk0x2q 134 38 was be VBD cord-007796-zggk0x2q 134 39 demonstrated demonstrate VBN cord-007796-zggk0x2q 135 1 ( ( -LRB- cord-007796-zggk0x2q 135 2 Hamming ham VBG cord-007796-zggk0x2q 135 3 et et FW cord-007796-zggk0x2q 135 4 al al NNP cord-007796-zggk0x2q 135 5 . . NNP cord-007796-zggk0x2q 135 6 , , , cord-007796-zggk0x2q 135 7 2004 2004 CD cord-007796-zggk0x2q 135 8 ) ) -RRB- cord-007796-zggk0x2q 135 9 . . . cord-007796-zggk0x2q 136 1 Transmission transmission NN cord-007796-zggk0x2q 136 2 of of IN cord-007796-zggk0x2q 136 3 SARS SARS NNP cord-007796-zggk0x2q 136 4 - - HYPH cord-007796-zggk0x2q 136 5 CoV CoV NNP cord-007796-zggk0x2q 136 6 occurs occur VBZ cord-007796-zggk0x2q 136 7 by by IN cord-007796-zggk0x2q 136 8 droplets droplet NNS cord-007796-zggk0x2q 136 9 and and CC cord-007796-zggk0x2q 136 10 most most JJS cord-007796-zggk0x2q 136 11 cases case NNS cord-007796-zggk0x2q 136 12 have have VBP cord-007796-zggk0x2q 136 13 occurred occur VBN cord-007796-zggk0x2q 136 14 through through IN cord-007796-zggk0x2q 136 15 close close JJ cord-007796-zggk0x2q 136 16 contact contact NN cord-007796-zggk0x2q 136 17 exposure exposure NN cord-007796-zggk0x2q 136 18 . . . cord-007796-zggk0x2q 137 1 However however RB cord-007796-zggk0x2q 137 2 , , , cord-007796-zggk0x2q 137 3 recently recently RB cord-007796-zggk0x2q 137 4 evidence evidence NN cord-007796-zggk0x2q 137 5 of of IN cord-007796-zggk0x2q 137 6 airborne airborne JJ cord-007796-zggk0x2q 137 7 transmission transmission NN cord-007796-zggk0x2q 137 8 has have VBZ cord-007796-zggk0x2q 137 9 emerged emerge VBN cord-007796-zggk0x2q 137 10 ( ( -LRB- cord-007796-zggk0x2q 137 11 Yu Yu NNP cord-007796-zggk0x2q 137 12 et et FW cord-007796-zggk0x2q 137 13 al al NNP cord-007796-zggk0x2q 137 14 . . NNP cord-007796-zggk0x2q 137 15 , , , cord-007796-zggk0x2q 137 16 2004 2004 CD cord-007796-zggk0x2q 137 17 ) ) -RRB- cord-007796-zggk0x2q 137 18 . . . cord-007796-zggk0x2q 138 1 Although although IN cord-007796-zggk0x2q 138 2 many many JJ cord-007796-zggk0x2q 138 3 individuals individual NNS cord-007796-zggk0x2q 138 4 were be VBD cord-007796-zggk0x2q 138 5 infected infect VBN cord-007796-zggk0x2q 138 6 in in IN cord-007796-zggk0x2q 138 7 the the DT cord-007796-zggk0x2q 138 8 initial initial JJ cord-007796-zggk0x2q 138 9 2 2 CD cord-007796-zggk0x2q 138 10 weeks week NNS cord-007796-zggk0x2q 138 11 of of IN cord-007796-zggk0x2q 138 12 the the DT cord-007796-zggk0x2q 138 13 epidemic epidemic NN cord-007796-zggk0x2q 138 14 and and CC cord-007796-zggk0x2q 138 15 the the DT cord-007796-zggk0x2q 138 16 disease disease NN cord-007796-zggk0x2q 138 17 spread spread VBD cord-007796-zggk0x2q 138 18 rapidly rapidly RB cord-007796-zggk0x2q 138 19 over over IN cord-007796-zggk0x2q 138 20 several several JJ cord-007796-zggk0x2q 138 21 countries country NNS cord-007796-zggk0x2q 138 22 , , , cord-007796-zggk0x2q 138 23 the the DT cord-007796-zggk0x2q 138 24 numbers number NNS cord-007796-zggk0x2q 138 25 of of IN cord-007796-zggk0x2q 138 26 infected infected JJ cord-007796-zggk0x2q 138 27 children child NNS cord-007796-zggk0x2q 138 28 stayed stay VBD cord-007796-zggk0x2q 138 29 relatively relatively RB cord-007796-zggk0x2q 138 30 low low JJ cord-007796-zggk0x2q 138 31 in in IN cord-007796-zggk0x2q 138 32 all all DT cord-007796-zggk0x2q 138 33 regions region NNS cord-007796-zggk0x2q 138 34 ( ( -LRB- cord-007796-zggk0x2q 138 35 Ͻ5 ͻ5 CD cord-007796-zggk0x2q 138 36 % % NN cord-007796-zggk0x2q 138 37 ) ) -RRB- cord-007796-zggk0x2q 138 38 . . . cord-007796-zggk0x2q 139 1 Furthermore furthermore RB cord-007796-zggk0x2q 139 2 , , , cord-007796-zggk0x2q 139 3 children child NNS cord-007796-zggk0x2q 139 4 tend tend VBP cord-007796-zggk0x2q 139 5 to to TO cord-007796-zggk0x2q 139 6 develop develop VB cord-007796-zggk0x2q 139 7 less less RBR cord-007796-zggk0x2q 139 8 severe severe JJ cord-007796-zggk0x2q 139 9 disease disease NN cord-007796-zggk0x2q 139 10 . . . cord-007796-zggk0x2q 140 1 After after IN cord-007796-zggk0x2q 140 2 an an DT cord-007796-zggk0x2q 140 3 incubation incubation NN cord-007796-zggk0x2q 140 4 period period NN cord-007796-zggk0x2q 140 5 of of IN cord-007796-zggk0x2q 140 6 5 5 CD cord-007796-zggk0x2q 140 7 - - SYM cord-007796-zggk0x2q 140 8 10 10 CD cord-007796-zggk0x2q 140 9 days day NNS cord-007796-zggk0x2q 140 10 , , , cord-007796-zggk0x2q 140 11 similar similar JJ cord-007796-zggk0x2q 140 12 to to IN cord-007796-zggk0x2q 140 13 adults adult NNS cord-007796-zggk0x2q 140 14 , , , cord-007796-zggk0x2q 140 15 infected infected JJ cord-007796-zggk0x2q 140 16 children child NNS cord-007796-zggk0x2q 140 17 developed develop VBD cord-007796-zggk0x2q 140 18 symptoms symptom NNS cord-007796-zggk0x2q 140 19 of of IN cord-007796-zggk0x2q 140 20 a a DT cord-007796-zggk0x2q 140 21 mild mild JJ cord-007796-zggk0x2q 140 22 upper upper JJ cord-007796-zggk0x2q 140 23 respiratory respiratory JJ cord-007796-zggk0x2q 140 24 tract tract NN cord-007796-zggk0x2q 140 25 infection infection NN cord-007796-zggk0x2q 140 26 , , , cord-007796-zggk0x2q 140 27 clinically clinically RB cord-007796-zggk0x2q 140 28 indistinguishable indistinguishable JJ cord-007796-zggk0x2q 140 29 from from IN cord-007796-zggk0x2q 140 30 other other JJ cord-007796-zggk0x2q 140 31 common common JJ cord-007796-zggk0x2q 140 32 colds cold NNS cord-007796-zggk0x2q 140 33 . . . cord-007796-zggk0x2q 141 1 None none NN cord-007796-zggk0x2q 141 2 of of IN cord-007796-zggk0x2q 141 3 the the DT cord-007796-zggk0x2q 141 4 100 100 CD cord-007796-zggk0x2q 141 5 pediatric pediatric JJ cord-007796-zggk0x2q 141 6 SARS SARS NNP cord-007796-zggk0x2q 141 7 cases case NNS cord-007796-zggk0x2q 141 8 in in IN cord-007796-zggk0x2q 141 9 Hong Hong NNP cord-007796-zggk0x2q 141 10 Kong Kong NNP cord-007796-zggk0x2q 141 11 turned turn VBD cord-007796-zggk0x2q 141 12 out out RP cord-007796-zggk0x2q 141 13 to to TO cord-007796-zggk0x2q 141 14 be be VB cord-007796-zggk0x2q 141 15 fatal fatal JJ cord-007796-zggk0x2q 141 16 and and CC cord-007796-zggk0x2q 141 17 only only RB cord-007796-zggk0x2q 141 18 one one CD cord-007796-zggk0x2q 141 19 adolescent adolescent NN cord-007796-zggk0x2q 141 20 required require VBN cord-007796-zggk0x2q 141 21 mechanical mechanical JJ cord-007796-zggk0x2q 141 22 ventilation ventilation NN cord-007796-zggk0x2q 141 23 ( ( -LRB- cord-007796-zggk0x2q 141 24 Leung Leung NNP cord-007796-zggk0x2q 141 25 et et NNP cord-007796-zggk0x2q 141 26 al al NNP cord-007796-zggk0x2q 141 27 . . NNP cord-007796-zggk0x2q 141 28 , , , cord-007796-zggk0x2q 141 29 2003 2003 CD cord-007796-zggk0x2q 141 30 ) ) -RRB- cord-007796-zggk0x2q 141 31 . . . cord-007796-zggk0x2q 142 1 Adolescents adolescent NNS cord-007796-zggk0x2q 142 2 are be VBP cord-007796-zggk0x2q 142 3 more more RBR cord-007796-zggk0x2q 142 4 likely likely JJ cord-007796-zggk0x2q 142 5 to to TO cord-007796-zggk0x2q 142 6 develop develop VB cord-007796-zggk0x2q 142 7 severe severe JJ cord-007796-zggk0x2q 142 8 disease disease NN cord-007796-zggk0x2q 142 9 , , , cord-007796-zggk0x2q 142 10 as as IN cord-007796-zggk0x2q 142 11 observed observe VBN cord-007796-zggk0x2q 142 12 in in IN cord-007796-zggk0x2q 142 13 adult adult NN cord-007796-zggk0x2q 142 14 SARS SARS NNP cord-007796-zggk0x2q 142 15 patients patient NNS cord-007796-zggk0x2q 142 16 ( ( -LRB- cord-007796-zggk0x2q 142 17 Leung Leung NNP cord-007796-zggk0x2q 142 18 et et NNP cord-007796-zggk0x2q 142 19 al al NNP cord-007796-zggk0x2q 142 20 . . NNP cord-007796-zggk0x2q 142 21 , , , cord-007796-zggk0x2q 142 22 2004 2004 CD cord-007796-zggk0x2q 142 23 ) ) -RRB- cord-007796-zggk0x2q 142 24 . . . cord-007796-zggk0x2q 143 1 A a DT cord-007796-zggk0x2q 143 2 sore sore JJ cord-007796-zggk0x2q 143 3 throat throat NN cord-007796-zggk0x2q 143 4 and and CC cord-007796-zggk0x2q 143 5 a a DT cord-007796-zggk0x2q 143 6 high high JJ cord-007796-zggk0x2q 143 7 initial initial JJ cord-007796-zggk0x2q 143 8 and and CC cord-007796-zggk0x2q 143 9 peak peak JJ cord-007796-zggk0x2q 143 10 peripheral peripheral JJ cord-007796-zggk0x2q 143 11 blood blood NN cord-007796-zggk0x2q 143 12 neutrophil neutrophil NN cord-007796-zggk0x2q 143 13 count count NN cord-007796-zggk0x2q 143 14 were be VBD cord-007796-zggk0x2q 143 15 found find VBN cord-007796-zggk0x2q 143 16 to to TO cord-007796-zggk0x2q 143 17 be be VB cord-007796-zggk0x2q 143 18 independent independent JJ cord-007796-zggk0x2q 143 19 risk risk NN cord-007796-zggk0x2q 143 20 factors factor NNS cord-007796-zggk0x2q 143 21 for for IN cord-007796-zggk0x2q 143 22 severe severe JJ cord-007796-zggk0x2q 143 23 disease disease NN cord-007796-zggk0x2q 143 24 in in IN cord-007796-zggk0x2q 143 25 children child NNS cord-007796-zggk0x2q 143 26 with with IN cord-007796-zggk0x2q 143 27 a a DT cord-007796-zggk0x2q 143 28 laboratory laboratory NN cord-007796-zggk0x2q 143 29 - - HYPH cord-007796-zggk0x2q 143 30 confirmed confirm VBN cord-007796-zggk0x2q 143 31 SARS SARS NNP cord-007796-zggk0x2q 143 32 infection infection NN cord-007796-zggk0x2q 143 33 . . . cord-007796-zggk0x2q 144 1 Furthermore furthermore RB cord-007796-zggk0x2q 144 2 , , , cord-007796-zggk0x2q 144 3 children child NNS cord-007796-zggk0x2q 144 4 seemed seem VBD cord-007796-zggk0x2q 144 5 to to TO cord-007796-zggk0x2q 144 6 spread spread VB cord-007796-zggk0x2q 144 7 the the DT cord-007796-zggk0x2q 144 8 disease disease NN cord-007796-zggk0x2q 144 9 less less RBR cord-007796-zggk0x2q 144 10 easily easily RB cord-007796-zggk0x2q 144 11 to to IN cord-007796-zggk0x2q 144 12 others other NNS cord-007796-zggk0x2q 144 13 and and CC cord-007796-zggk0x2q 144 14 there there EX cord-007796-zggk0x2q 144 15 have have VBP cord-007796-zggk0x2q 144 16 appeared appear VBN cord-007796-zggk0x2q 144 17 no no DT cord-007796-zggk0x2q 144 18 reports report NNS cord-007796-zggk0x2q 144 19 in in IN cord-007796-zggk0x2q 144 20 the the DT cord-007796-zggk0x2q 144 21 literature literature NN cord-007796-zggk0x2q 144 22 demonstrating demonstrate VBG cord-007796-zggk0x2q 144 23 transmission transmission NN cord-007796-zggk0x2q 144 24 from from IN cord-007796-zggk0x2q 144 25 children child NNS cord-007796-zggk0x2q 144 26 to to IN cord-007796-zggk0x2q 144 27 other other JJ cord-007796-zggk0x2q 144 28 individuals individual NNS cord-007796-zggk0x2q 144 29 . . . cord-007796-zggk0x2q 145 1 Many many JJ cord-007796-zggk0x2q 145 2 children child NNS cord-007796-zggk0x2q 145 3 with with IN cord-007796-zggk0x2q 145 4 laboratory laboratory NN cord-007796-zggk0x2q 145 5 - - HYPH cord-007796-zggk0x2q 145 6 confirmed confirm VBN cord-007796-zggk0x2q 145 7 SARS SARS NNP cord-007796-zggk0x2q 145 8 do do VBP cord-007796-zggk0x2q 145 9 not not RB cord-007796-zggk0x2q 145 10 meet meet VB cord-007796-zggk0x2q 145 11 the the DT cord-007796-zggk0x2q 145 12 WHO WHO NNP cord-007796-zggk0x2q 145 13 criteria criteria VBZ cord-007796-zggk0x2q 145 14 for for IN cord-007796-zggk0x2q 145 15 diagnosis diagnosis NN cord-007796-zggk0x2q 145 16 of of IN cord-007796-zggk0x2q 145 17 SARS SARS NNP cord-007796-zggk0x2q 145 18 . . . cord-007796-zggk0x2q 146 1 As as IN cord-007796-zggk0x2q 146 2 children child NNS cord-007796-zggk0x2q 146 3 seem seem VBP cord-007796-zggk0x2q 146 4 to to TO cord-007796-zggk0x2q 146 5 have have VB cord-007796-zggk0x2q 146 6 a a DT cord-007796-zggk0x2q 146 7 much much RB cord-007796-zggk0x2q 146 8 milder mild JJR cord-007796-zggk0x2q 146 9 clinical clinical JJ cord-007796-zggk0x2q 146 10 course course NN cord-007796-zggk0x2q 146 11 , , , cord-007796-zggk0x2q 146 12 the the DT cord-007796-zggk0x2q 146 13 term term NN cord-007796-zggk0x2q 146 14 " " `` cord-007796-zggk0x2q 146 15 SARS SARS NNP cord-007796-zggk0x2q 146 16 " " '' cord-007796-zggk0x2q 146 17 may may MD cord-007796-zggk0x2q 146 18 not not RB cord-007796-zggk0x2q 146 19 represent represent VB cord-007796-zggk0x2q 146 20 the the DT cord-007796-zggk0x2q 146 21 disease disease NN cord-007796-zggk0x2q 146 22 in in IN cord-007796-zggk0x2q 146 23 children child NNS cord-007796-zggk0x2q 146 24 very very RB cord-007796-zggk0x2q 146 25 well well RB cord-007796-zggk0x2q 146 26 . . . cord-007796-zggk0x2q 147 1 The the DT cord-007796-zggk0x2q 147 2 role role NN cord-007796-zggk0x2q 147 3 of of IN cord-007796-zggk0x2q 147 4 the the DT cord-007796-zggk0x2q 147 5 innate innate JJ cord-007796-zggk0x2q 147 6 immune immune JJ cord-007796-zggk0x2q 147 7 system system NN cord-007796-zggk0x2q 147 8 in in IN cord-007796-zggk0x2q 147 9 viral viral JJ cord-007796-zggk0x2q 147 10 lower low JJR cord-007796-zggk0x2q 147 11 respiratory respiratory JJ cord-007796-zggk0x2q 147 12 tract tract NN cord-007796-zggk0x2q 147 13 infection infection NN cord-007796-zggk0x2q 147 14 has have VBZ cord-007796-zggk0x2q 147 15 not not RB cord-007796-zggk0x2q 147 16 been be VBN cord-007796-zggk0x2q 147 17 studied study VBN cord-007796-zggk0x2q 147 18 intensively intensively RB cord-007796-zggk0x2q 147 19 until until IN cord-007796-zggk0x2q 147 20 recently recently RB cord-007796-zggk0x2q 147 21 . . . cord-007796-zggk0x2q 148 1 Studies study NNS cord-007796-zggk0x2q 148 2 have have VBP cord-007796-zggk0x2q 148 3 focused focus VBN cord-007796-zggk0x2q 148 4 on on IN cord-007796-zggk0x2q 148 5 the the DT cord-007796-zggk0x2q 148 6 adaptive adaptive JJ cord-007796-zggk0x2q 148 7 immunity immunity NN cord-007796-zggk0x2q 148 8 with with IN cord-007796-zggk0x2q 148 9 the the DT cord-007796-zggk0x2q 148 10 goal goal NN cord-007796-zggk0x2q 148 11 of of IN cord-007796-zggk0x2q 148 12 developing develop VBG cord-007796-zggk0x2q 148 13 a a DT cord-007796-zggk0x2q 148 14 vaccine vaccine NN cord-007796-zggk0x2q 148 15 , , , cord-007796-zggk0x2q 148 16 for for IN cord-007796-zggk0x2q 148 17 example example NN cord-007796-zggk0x2q 148 18 , , , cord-007796-zggk0x2q 148 19 for for IN cord-007796-zggk0x2q 148 20 RSV RSV NNP cord-007796-zggk0x2q 148 21 . . . cord-007796-zggk0x2q 149 1 Understanding understand VBG cord-007796-zggk0x2q 149 2 the the DT cord-007796-zggk0x2q 149 3 mechanisms mechanism NNS cord-007796-zggk0x2q 149 4 underlying underlie VBG cord-007796-zggk0x2q 149 5 primary primary JJ cord-007796-zggk0x2q 149 6 and and CC cord-007796-zggk0x2q 149 7 recurrent recurrent JJ cord-007796-zggk0x2q 149 8 viral viral JJ cord-007796-zggk0x2q 149 9 infection infection NN cord-007796-zggk0x2q 149 10 has have VBZ cord-007796-zggk0x2q 149 11 attracted attract VBN cord-007796-zggk0x2q 149 12 increased increase VBN cord-007796-zggk0x2q 149 13 attention attention NN cord-007796-zggk0x2q 149 14 . . . cord-007796-zggk0x2q 150 1 The the DT cord-007796-zggk0x2q 150 2 immunological immunological JJ cord-007796-zggk0x2q 150 3 response response NN cord-007796-zggk0x2q 150 4 against against IN cord-007796-zggk0x2q 150 5 viral viral JJ cord-007796-zggk0x2q 150 6 invasion invasion NN cord-007796-zggk0x2q 150 7 of of IN cord-007796-zggk0x2q 150 8 the the DT cord-007796-zggk0x2q 150 9 lower low JJR cord-007796-zggk0x2q 150 10 respiratory respiratory JJ cord-007796-zggk0x2q 150 11 tract tract NN cord-007796-zggk0x2q 150 12 comprises comprise VBZ cord-007796-zggk0x2q 150 13 both both CC cord-007796-zggk0x2q 150 14 adaptive adaptive JJ cord-007796-zggk0x2q 150 15 and and CC cord-007796-zggk0x2q 150 16 innate innate JJ cord-007796-zggk0x2q 150 17 immune immune JJ cord-007796-zggk0x2q 150 18 response response NN cord-007796-zggk0x2q 150 19 mechanisms mechanism NNS cord-007796-zggk0x2q 150 20 with with IN cord-007796-zggk0x2q 150 21 both both DT cord-007796-zggk0x2q 150 22 beneficial beneficial JJ cord-007796-zggk0x2q 150 23 as as RB cord-007796-zggk0x2q 150 24 well well RB cord-007796-zggk0x2q 150 25 as as IN cord-007796-zggk0x2q 150 26 detrimental detrimental JJ cord-007796-zggk0x2q 150 27 characteristics characteristic NNS cord-007796-zggk0x2q 150 28 . . . cord-007796-zggk0x2q 151 1 The the DT cord-007796-zggk0x2q 151 2 innate innate JJ cord-007796-zggk0x2q 151 3 response response NN cord-007796-zggk0x2q 151 4 occurs occur VBZ cord-007796-zggk0x2q 151 5 in in IN cord-007796-zggk0x2q 151 6 the the DT cord-007796-zggk0x2q 151 7 early early JJ cord-007796-zggk0x2q 151 8 phase phase NN cord-007796-zggk0x2q 151 9 of of IN cord-007796-zggk0x2q 151 10 the the DT cord-007796-zggk0x2q 151 11 infection infection NN cord-007796-zggk0x2q 151 12 and and CC cord-007796-zggk0x2q 151 13 increasing increase VBG cord-007796-zggk0x2q 151 14 evidence evidence NN cord-007796-zggk0x2q 151 15 suggests suggest VBZ cord-007796-zggk0x2q 151 16 that that IN cord-007796-zggk0x2q 151 17 these these DT cord-007796-zggk0x2q 151 18 early early JJ cord-007796-zggk0x2q 151 19 events event NNS cord-007796-zggk0x2q 151 20 determine determine VBP cord-007796-zggk0x2q 151 21 disease disease NN cord-007796-zggk0x2q 151 22 course course NN cord-007796-zggk0x2q 151 23 and and CC cord-007796-zggk0x2q 151 24 possibly possibly RB cord-007796-zggk0x2q 151 25 even even RB cord-007796-zggk0x2q 151 26 long long JJ cord-007796-zggk0x2q 151 27 - - HYPH cord-007796-zggk0x2q 151 28 term term NN cord-007796-zggk0x2q 151 29 outcome outcome NN cord-007796-zggk0x2q 151 30 ( ( -LRB- cord-007796-zggk0x2q 151 31 Garofalo Garofalo NNP cord-007796-zggk0x2q 151 32 and and CC cord-007796-zggk0x2q 151 33 Haeberle Haeberle NNP cord-007796-zggk0x2q 151 34 , , , cord-007796-zggk0x2q 151 35 2000 2000 CD cord-007796-zggk0x2q 151 36 ; ; : cord-007796-zggk0x2q 152 1 Tasker Tasker NNP cord-007796-zggk0x2q 152 2 et et NNP cord-007796-zggk0x2q 152 3 al al NNP cord-007796-zggk0x2q 152 4 . . NNP cord-007796-zggk0x2q 152 5 , , , cord-007796-zggk0x2q 152 6 2000 2000 CD cord-007796-zggk0x2q 152 7 ) ) -RRB- cord-007796-zggk0x2q 152 8 . . . cord-007796-zggk0x2q 153 1 For for IN cord-007796-zggk0x2q 153 2 the the DT cord-007796-zggk0x2q 153 3 rest rest NN cord-007796-zggk0x2q 153 4 of of IN cord-007796-zggk0x2q 153 5 the the DT cord-007796-zggk0x2q 153 6 discussion discussion NN cord-007796-zggk0x2q 153 7 on on IN cord-007796-zggk0x2q 153 8 immunological immunological JJ cord-007796-zggk0x2q 153 9 phenomena phenomenon NNS cord-007796-zggk0x2q 153 10 , , , cord-007796-zggk0x2q 153 11 focus focus NN cord-007796-zggk0x2q 153 12 will will MD cord-007796-zggk0x2q 153 13 be be VB cord-007796-zggk0x2q 153 14 on on IN cord-007796-zggk0x2q 153 15 RSV RSV NNP cord-007796-zggk0x2q 153 16 as as IN cord-007796-zggk0x2q 153 17 a a DT cord-007796-zggk0x2q 153 18 prototype prototype NN cord-007796-zggk0x2q 153 19 . . . cord-007796-zggk0x2q 154 1 Epithelial epithelial JJ cord-007796-zggk0x2q 154 2 cells cell NNS cord-007796-zggk0x2q 154 3 are be VBP cord-007796-zggk0x2q 154 4 key key JJ cord-007796-zggk0x2q 154 5 regulators regulator NNS cord-007796-zggk0x2q 154 6 of of IN cord-007796-zggk0x2q 154 7 the the DT cord-007796-zggk0x2q 154 8 innate innate JJ cord-007796-zggk0x2q 154 9 immune immune JJ cord-007796-zggk0x2q 154 10 response response NN cord-007796-zggk0x2q 154 11 against against IN cord-007796-zggk0x2q 154 12 viral viral JJ cord-007796-zggk0x2q 154 13 infections infection NNS cord-007796-zggk0x2q 154 14 ( ( -LRB- cord-007796-zggk0x2q 154 15 Garofalo Garofalo NNP cord-007796-zggk0x2q 154 16 and and CC cord-007796-zggk0x2q 154 17 Haeberle Haeberle NNP cord-007796-zggk0x2q 154 18 , , , cord-007796-zggk0x2q 154 19 2000 2000 CD cord-007796-zggk0x2q 154 20 ) ) -RRB- cord-007796-zggk0x2q 154 21 , , , cord-007796-zggk0x2q 154 22 producing produce VBG cord-007796-zggk0x2q 154 23 a a DT cord-007796-zggk0x2q 154 24 number number NN cord-007796-zggk0x2q 154 25 of of IN cord-007796-zggk0x2q 154 26 inflammatory inflammatory JJ cord-007796-zggk0x2q 154 27 mediators mediator NNS cord-007796-zggk0x2q 154 28 in in IN cord-007796-zggk0x2q 154 29 response response NN cord-007796-zggk0x2q 154 30 to to IN cord-007796-zggk0x2q 154 31 RSV RSV NNP cord-007796-zggk0x2q 154 32 infection infection NN cord-007796-zggk0x2q 154 33 . . . cord-007796-zggk0x2q 155 1 These these DT cord-007796-zggk0x2q 155 2 include include VBP cord-007796-zggk0x2q 155 3 cytokines cytokine NNS cord-007796-zggk0x2q 155 4 ( ( -LRB- cord-007796-zggk0x2q 155 5 interleukin-6 interleukin-6 NNP cord-007796-zggk0x2q 155 6 , , , cord-007796-zggk0x2q 155 7 -1 -1 NN cord-007796-zggk0x2q 155 8 , , , cord-007796-zggk0x2q 155 9 tumor tumor NN cord-007796-zggk0x2q 155 10 necrosis necrosis NN cord-007796-zggk0x2q 155 11 factor factor NN cord-007796-zggk0x2q 155 12 ( ( -LRB- cord-007796-zggk0x2q 155 13 TNF)- TNF)- NNP cord-007796-zggk0x2q 155 14 ␣ ␣ NNP cord-007796-zggk0x2q 155 15 ) ) -RRB- cord-007796-zggk0x2q 155 16 , , , cord-007796-zggk0x2q 155 17 several several JJ cord-007796-zggk0x2q 155 18 chemokines chemokine NNS cord-007796-zggk0x2q 155 19 ( ( -LRB- cord-007796-zggk0x2q 155 20 IL-8 IL-8 NNP cord-007796-zggk0x2q 155 21 , , , cord-007796-zggk0x2q 155 22 macrophage macrophage VB cord-007796-zggk0x2q 155 23 inflammatory inflammatory JJ cord-007796-zggk0x2q 155 24 protein protein NN cord-007796-zggk0x2q 155 25 ( ( -LRB- cord-007796-zggk0x2q 155 26 MIP)-1 MIP)-1 NNP cord-007796-zggk0x2q 155 27 ␣ ␣ NNP cord-007796-zggk0x2q 155 28 , , , cord-007796-zggk0x2q 155 29 monocyte monocyte NNP cord-007796-zggk0x2q 155 30 chemotactic chemotactic JJ cord-007796-zggk0x2q 155 31 protein protein NN cord-007796-zggk0x2q 155 32 ( ( -LRB- cord-007796-zggk0x2q 155 33 MCP-1 MCP-1 NNP cord-007796-zggk0x2q 155 34 ) ) -RRB- cord-007796-zggk0x2q 155 35 , , , cord-007796-zggk0x2q 155 36 RANTES RANTES NNP cord-007796-zggk0x2q 155 37 ) ) -RRB- cord-007796-zggk0x2q 155 38 , , , cord-007796-zggk0x2q 155 39 type type NN cord-007796-zggk0x2q 155 40 - - HYPH cord-007796-zggk0x2q 155 41 l l NN cord-007796-zggk0x2q 155 42 interferon interferon NN cord-007796-zggk0x2q 155 43 ( ( -LRB- cord-007796-zggk0x2q 155 44 IFN- IFN- NNP cord-007796-zggk0x2q 155 45 ␣ ␣ NNP cord-007796-zggk0x2q 155 46 / / SYM cord-007796-zggk0x2q 155 47 ␤ ␤ NNP cord-007796-zggk0x2q 155 48 ) ) -RRB- cord-007796-zggk0x2q 155 49 , , , cord-007796-zggk0x2q 155 50 and and CC cord-007796-zggk0x2q 155 51 growth growth NN cord-007796-zggk0x2q 155 52 factors factor NNS cord-007796-zggk0x2q 155 53 ( ( -LRB- cord-007796-zggk0x2q 155 54 GM GM NNP cord-007796-zggk0x2q 155 55 - - HYPH cord-007796-zggk0x2q 155 56 CSF CSF NNP cord-007796-zggk0x2q 155 57 , , , cord-007796-zggk0x2q 155 58 G G NNP cord-007796-zggk0x2q 155 59 - - HYPH cord-007796-zggk0x2q 155 60 CSF CSF NNP cord-007796-zggk0x2q 155 61 ) ) -RRB- cord-007796-zggk0x2q 155 62 . . . cord-007796-zggk0x2q 156 1 Epithelial epithelial NN cord-007796-zggk0x2q 156 2 - - HYPH cord-007796-zggk0x2q 156 3 derived derive VBN cord-007796-zggk0x2q 156 4 levels level NNS cord-007796-zggk0x2q 156 5 of of IN cord-007796-zggk0x2q 156 6 chemokines chemokine NNS cord-007796-zggk0x2q 156 7 correlate correlate VBP cord-007796-zggk0x2q 156 8 with with IN cord-007796-zggk0x2q 156 9 disease disease NN cord-007796-zggk0x2q 156 10 severity severity NN cord-007796-zggk0x2q 156 11 ( ( -LRB- cord-007796-zggk0x2q 156 12 Bont Bont NNP cord-007796-zggk0x2q 156 13 et et NNP cord-007796-zggk0x2q 156 14 al al NNP cord-007796-zggk0x2q 156 15 . . NNP cord-007796-zggk0x2q 156 16 , , , cord-007796-zggk0x2q 156 17 1999 1999 CD cord-007796-zggk0x2q 156 18 ; ; : cord-007796-zggk0x2q 156 19 Smyth Smyth NNP cord-007796-zggk0x2q 156 20 et et NNP cord-007796-zggk0x2q 156 21 al al NNP cord-007796-zggk0x2q 156 22 . . NNP cord-007796-zggk0x2q 156 23 , , , cord-007796-zggk0x2q 156 24 2002 2002 CD cord-007796-zggk0x2q 156 25 ) ) -RRB- cord-007796-zggk0x2q 156 26 . . . cord-007796-zggk0x2q 157 1 Surfactant surfactant NN cord-007796-zggk0x2q 157 2 proteins protein NNS cord-007796-zggk0x2q 157 3 produced produce VBN cord-007796-zggk0x2q 157 4 by by IN cord-007796-zggk0x2q 157 5 epithelial epithelial JJ cord-007796-zggk0x2q 157 6 cells cell NNS cord-007796-zggk0x2q 157 7 ( ( -LRB- cord-007796-zggk0x2q 157 8 SP SP NNP cord-007796-zggk0x2q 157 9 - - HYPH cord-007796-zggk0x2q 157 10 A A NNP cord-007796-zggk0x2q 157 11 and and CC cord-007796-zggk0x2q 157 12 SP SP NNP cord-007796-zggk0x2q 157 13 - - HYPH cord-007796-zggk0x2q 157 14 D D NNP cord-007796-zggk0x2q 157 15 ) ) -RRB- cord-007796-zggk0x2q 157 16 may may MD cord-007796-zggk0x2q 157 17 also also RB cord-007796-zggk0x2q 157 18 play play VB cord-007796-zggk0x2q 157 19 a a DT cord-007796-zggk0x2q 157 20 role role NN cord-007796-zggk0x2q 157 21 as as IN cord-007796-zggk0x2q 157 22 opsonins opsonins NNP cord-007796-zggk0x2q 157 23 for for IN cord-007796-zggk0x2q 157 24 viruses virus NNS cord-007796-zggk0x2q 157 25 and and CC cord-007796-zggk0x2q 157 26 bacteria bacteria NNS cord-007796-zggk0x2q 157 27 . . . cord-007796-zggk0x2q 158 1 Thus thus RB cord-007796-zggk0x2q 158 2 , , , cord-007796-zggk0x2q 158 3 epithelial epithelial JJ cord-007796-zggk0x2q 158 4 cells cell NNS cord-007796-zggk0x2q 158 5 provide provide VBP cord-007796-zggk0x2q 158 6 a a DT cord-007796-zggk0x2q 158 7 potential potential JJ cord-007796-zggk0x2q 158 8 mechanism mechanism NN cord-007796-zggk0x2q 158 9 for for IN cord-007796-zggk0x2q 158 10 serum serum NN cord-007796-zggk0x2q 158 11 - - HYPH cord-007796-zggk0x2q 158 12 independent independent JJ cord-007796-zggk0x2q 158 13 phagocytosis phagocytosis NN cord-007796-zggk0x2q 158 14 . . . cord-007796-zggk0x2q 159 1 Many many JJ cord-007796-zggk0x2q 159 2 of of IN cord-007796-zggk0x2q 159 3 these these DT cord-007796-zggk0x2q 159 4 mediators mediator NNS cord-007796-zggk0x2q 159 5 are be VBP cord-007796-zggk0x2q 159 6 induced induce VBN cord-007796-zggk0x2q 159 7 both both CC cord-007796-zggk0x2q 159 8 at at IN cord-007796-zggk0x2q 159 9 the the DT cord-007796-zggk0x2q 159 10 level level NN cord-007796-zggk0x2q 159 11 of of IN cord-007796-zggk0x2q 159 12 secretion secretion NN cord-007796-zggk0x2q 159 13 and and CC cord-007796-zggk0x2q 159 14 transcription transcription NN cord-007796-zggk0x2q 159 15 . . . cord-007796-zggk0x2q 160 1 Interestingly interestingly RB cord-007796-zggk0x2q 160 2 , , , cord-007796-zggk0x2q 160 3 some some DT cord-007796-zggk0x2q 160 4 mediators mediator NNS cord-007796-zggk0x2q 160 5 ( ( -LRB- cord-007796-zggk0x2q 160 6 e.g. e.g. RB cord-007796-zggk0x2q 160 7 , , , cord-007796-zggk0x2q 160 8 IL-8 IL-8 NNP cord-007796-zggk0x2q 160 9 and and CC cord-007796-zggk0x2q 160 10 RANTES RANTES NNP cord-007796-zggk0x2q 160 11 ) ) -RRB- cord-007796-zggk0x2q 160 12 are be VBP cord-007796-zggk0x2q 160 13 also also RB cord-007796-zggk0x2q 160 14 upregulated upregulate VBN cord-007796-zggk0x2q 160 15 by by IN cord-007796-zggk0x2q 160 16 inactive inactive JJ cord-007796-zggk0x2q 160 17 forms form NNS cord-007796-zggk0x2q 160 18 of of IN cord-007796-zggk0x2q 160 19 the the DT cord-007796-zggk0x2q 160 20 virus virus NN cord-007796-zggk0x2q 161 1 ( ( -LRB- cord-007796-zggk0x2q 161 2 Harrison Harrison NNP cord-007796-zggk0x2q 161 3 et et NNP cord-007796-zggk0x2q 161 4 al al NNP cord-007796-zggk0x2q 161 5 . . NNP cord-007796-zggk0x2q 161 6 , , , cord-007796-zggk0x2q 161 7 1999 1999 CD cord-007796-zggk0x2q 161 8 ) ) -RRB- cord-007796-zggk0x2q 161 9 . . . cord-007796-zggk0x2q 162 1 RSV RSV NNP cord-007796-zggk0x2q 162 2 uptake uptake NN cord-007796-zggk0x2q 162 3 by by IN cord-007796-zggk0x2q 162 4 immune immune JJ cord-007796-zggk0x2q 162 5 and and CC cord-007796-zggk0x2q 162 6 non non JJ cord-007796-zggk0x2q 162 7 - - JJ cord-007796-zggk0x2q 162 8 immune immune JJ cord-007796-zggk0x2q 162 9 cells cell NNS cord-007796-zggk0x2q 162 10 is be VBZ cord-007796-zggk0x2q 162 11 a a DT cord-007796-zggk0x2q 162 12 receptor receptor NN cord-007796-zggk0x2q 162 13 - - HYPH cord-007796-zggk0x2q 162 14 mediated mediate VBN cord-007796-zggk0x2q 162 15 process process NN cord-007796-zggk0x2q 162 16 . . . cord-007796-zggk0x2q 163 1 Experiments experiment NNS cord-007796-zggk0x2q 163 2 with with IN cord-007796-zggk0x2q 163 3 blocking block VBG cord-007796-zggk0x2q 163 4 antibodies antibody NNS cord-007796-zggk0x2q 163 5 against against IN cord-007796-zggk0x2q 163 6 G g NN cord-007796-zggk0x2q 163 7 - - HYPH cord-007796-zggk0x2q 163 8 protein protein NN cord-007796-zggk0x2q 163 9 revealed reveal VBD cord-007796-zggk0x2q 163 10 inhibition inhibition NN cord-007796-zggk0x2q 163 11 of of IN cord-007796-zggk0x2q 163 12 binding bind VBG cord-007796-zggk0x2q 163 13 of of IN cord-007796-zggk0x2q 163 14 RSV RSV NNP cord-007796-zggk0x2q 163 15 to to IN cord-007796-zggk0x2q 163 16 epithelial epithelial JJ cord-007796-zggk0x2q 163 17 cells cell NNS cord-007796-zggk0x2q 163 18 . . . cord-007796-zggk0x2q 164 1 The the DT cord-007796-zggk0x2q 164 2 fractalkine fractalkine JJ cord-007796-zggk0x2q 164 3 receptor receptor NN cord-007796-zggk0x2q 164 4 , , , cord-007796-zggk0x2q 164 5 also also RB cord-007796-zggk0x2q 164 6 known know VBN cord-007796-zggk0x2q 164 7 as as IN cord-007796-zggk0x2q 164 8 the the DT cord-007796-zggk0x2q 164 9 CX3CR1 CX3CR1 NNP cord-007796-zggk0x2q 164 10 chemokine chemokine NN cord-007796-zggk0x2q 164 11 receptor receptor NN cord-007796-zggk0x2q 164 12 , , , cord-007796-zggk0x2q 164 13 is be VBZ cord-007796-zggk0x2q 164 14 involved involve VBN cord-007796-zggk0x2q 164 15 in in IN cord-007796-zggk0x2q 164 16 G g NN cord-007796-zggk0x2q 164 17 - - HYPH cord-007796-zggk0x2q 164 18 protein protein NN cord-007796-zggk0x2q 164 19 - - HYPH cord-007796-zggk0x2q 164 20 mediated mediate VBN cord-007796-zggk0x2q 164 21 uptake uptake NN cord-007796-zggk0x2q 164 22 by by IN cord-007796-zggk0x2q 164 23 epithelial epithelial JJ cord-007796-zggk0x2q 164 24 cells cell NNS cord-007796-zggk0x2q 164 25 . . . cord-007796-zggk0x2q 165 1 Other other JJ cord-007796-zggk0x2q 165 2 receptors receptor NNS cord-007796-zggk0x2q 165 3 may may MD cord-007796-zggk0x2q 165 4 very very RB cord-007796-zggk0x2q 165 5 well well RB cord-007796-zggk0x2q 165 6 be be VB cord-007796-zggk0x2q 165 7 involved involve VBN cord-007796-zggk0x2q 165 8 in in IN cord-007796-zggk0x2q 165 9 uptake uptake NN cord-007796-zggk0x2q 165 10 by by IN cord-007796-zggk0x2q 165 11 dendritic dendritic JJ cord-007796-zggk0x2q 165 12 cells cell NNS cord-007796-zggk0x2q 165 13 , , , cord-007796-zggk0x2q 165 14 macrophages macrophage NNS cord-007796-zggk0x2q 165 15 , , , cord-007796-zggk0x2q 165 16 and and CC cord-007796-zggk0x2q 165 17 other other JJ cord-007796-zggk0x2q 165 18 cells cell NNS cord-007796-zggk0x2q 165 19 of of IN cord-007796-zggk0x2q 165 20 the the DT cord-007796-zggk0x2q 165 21 innate innate JJ cord-007796-zggk0x2q 165 22 immune immune JJ cord-007796-zggk0x2q 165 23 system system NN cord-007796-zggk0x2q 165 24 ( ( -LRB- cord-007796-zggk0x2q 165 25 Harris Harris NNP cord-007796-zggk0x2q 165 26 and and CC cord-007796-zggk0x2q 165 27 Werling Werling NNP cord-007796-zggk0x2q 165 28 , , , cord-007796-zggk0x2q 165 29 2003 2003 CD cord-007796-zggk0x2q 165 30 ) ) -RRB- cord-007796-zggk0x2q 165 31 , , , cord-007796-zggk0x2q 165 32 and and CC cord-007796-zggk0x2q 165 33 Toll toll NN cord-007796-zggk0x2q 165 34 - - HYPH cord-007796-zggk0x2q 165 35 like like JJ cord-007796-zggk0x2q 165 36 receptors receptor NNS cord-007796-zggk0x2q 165 37 ( ( -LRB- cord-007796-zggk0x2q 165 38 TLRs TLRs NNP cord-007796-zggk0x2q 165 39 ) ) -RRB- cord-007796-zggk0x2q 165 40 , , , cord-007796-zggk0x2q 165 41 especially especially RB cord-007796-zggk0x2q 165 42 TLR-4 TLR-4 NNP cord-007796-zggk0x2q 165 43 , , , cord-007796-zggk0x2q 165 44 are be VBP cord-007796-zggk0x2q 165 45 being be VBG cord-007796-zggk0x2q 165 46 investigated investigate VBN cord-007796-zggk0x2q 165 47 as as IN cord-007796-zggk0x2q 165 48 possible possible JJ cord-007796-zggk0x2q 165 49 candidates candidate NNS cord-007796-zggk0x2q 165 50 for for IN cord-007796-zggk0x2q 165 51 mediating mediate VBG cord-007796-zggk0x2q 165 52 viral viral JJ cord-007796-zggk0x2q 165 53 uptake uptake NN cord-007796-zggk0x2q 166 1 ( ( -LRB- cord-007796-zggk0x2q 166 2 Haeberle Haeberle NNP cord-007796-zggk0x2q 166 3 et et NNP cord-007796-zggk0x2q 166 4 al al NNP cord-007796-zggk0x2q 166 5 . . NNP cord-007796-zggk0x2q 166 6 , , , cord-007796-zggk0x2q 166 7 2002a 2002a CD cord-007796-zggk0x2q 166 8 , , , cord-007796-zggk0x2q 166 9 b b LS cord-007796-zggk0x2q 167 1 ; ; : cord-007796-zggk0x2q 167 2 Monick Monick NNP cord-007796-zggk0x2q 167 3 et et NNP cord-007796-zggk0x2q 167 4 al al NNP cord-007796-zggk0x2q 167 5 . . NNP cord-007796-zggk0x2q 167 6 , , , cord-007796-zggk0x2q 167 7 2003 2003 CD cord-007796-zggk0x2q 167 8 ) ) -RRB- cord-007796-zggk0x2q 167 9 . . . cord-007796-zggk0x2q 168 1 Several several JJ cord-007796-zggk0x2q 168 2 groups group NNS cord-007796-zggk0x2q 168 3 have have VBP cord-007796-zggk0x2q 168 4 demonstrated demonstrate VBN cord-007796-zggk0x2q 168 5 activation activation NN cord-007796-zggk0x2q 168 6 of of IN cord-007796-zggk0x2q 168 7 the the DT cord-007796-zggk0x2q 168 8 transcription transcription NN cord-007796-zggk0x2q 168 9 factor factor NN cord-007796-zggk0x2q 168 10 NF NF NNP cord-007796-zggk0x2q 168 11 - - HYPH cord-007796-zggk0x2q 168 12 kB kB NNP cord-007796-zggk0x2q 168 13 in in IN cord-007796-zggk0x2q 168 14 RSV RSV NNP cord-007796-zggk0x2q 168 15 - - HYPH cord-007796-zggk0x2q 168 16 infected infect VBN cord-007796-zggk0x2q 168 17 epithelial epithelial JJ cord-007796-zggk0x2q 168 18 cells cell NNS cord-007796-zggk0x2q 169 1 ( ( -LRB- cord-007796-zggk0x2q 169 2 Tian Tian NNP cord-007796-zggk0x2q 169 3 et et FW cord-007796-zggk0x2q 169 4 al al NNP cord-007796-zggk0x2q 169 5 . . NNP cord-007796-zggk0x2q 169 6 , , , cord-007796-zggk0x2q 169 7 2002 2002 CD cord-007796-zggk0x2q 169 8 ) ) -RRB- cord-007796-zggk0x2q 169 9 . . . cord-007796-zggk0x2q 170 1 Many many JJ cord-007796-zggk0x2q 170 2 of of IN cord-007796-zggk0x2q 170 3 the the DT cord-007796-zggk0x2q 170 4 exhibited exhibit VBN cord-007796-zggk0x2q 170 5 effects effect NNS cord-007796-zggk0x2q 170 6 observed observe VBN cord-007796-zggk0x2q 170 7 in in IN cord-007796-zggk0x2q 170 8 epithelial epithelial JJ cord-007796-zggk0x2q 170 9 cells cell NNS cord-007796-zggk0x2q 170 10 can can MD cord-007796-zggk0x2q 170 11 be be VB cord-007796-zggk0x2q 170 12 explained explain VBN cord-007796-zggk0x2q 170 13 by by IN cord-007796-zggk0x2q 170 14 activation activation NN cord-007796-zggk0x2q 170 15 of of IN cord-007796-zggk0x2q 170 16 NF nf NN cord-007796-zggk0x2q 170 17 - - HYPH cord-007796-zggk0x2q 170 18 kB. kB. NNP cord-007796-zggk0x2q 170 19 Several several JJ cord-007796-zggk0x2q 170 20 cytokines cytokine NNS cord-007796-zggk0x2q 170 21 associated associate VBN cord-007796-zggk0x2q 170 22 with with IN cord-007796-zggk0x2q 170 23 RSV RSV NNP cord-007796-zggk0x2q 170 24 infection infection NN cord-007796-zggk0x2q 170 25 have have VBP cord-007796-zggk0x2q 170 26 NF NF NNP cord-007796-zggk0x2q 170 27 - - HYPH cord-007796-zggk0x2q 170 28 kB kB NNP cord-007796-zggk0x2q 170 29 binding binding NN cord-007796-zggk0x2q 170 30 sites site NNS cord-007796-zggk0x2q 170 31 in in IN cord-007796-zggk0x2q 170 32 their -PRON- PRP$ cord-007796-zggk0x2q 170 33 promoter promoter NN cord-007796-zggk0x2q 170 34 or or CC cord-007796-zggk0x2q 170 35 enhancer enhancer NN cord-007796-zggk0x2q 170 36 regions region NNS cord-007796-zggk0x2q 170 37 ( ( -LRB- cord-007796-zggk0x2q 170 38 Bitko Bitko NNP cord-007796-zggk0x2q 170 39 et et FW cord-007796-zggk0x2q 170 40 al al NNP cord-007796-zggk0x2q 170 41 . . NNP cord-007796-zggk0x2q 170 42 , , , cord-007796-zggk0x2q 170 43 1997 1997 CD cord-007796-zggk0x2q 170 44 ) ) -RRB- cord-007796-zggk0x2q 170 45 . . . cord-007796-zggk0x2q 171 1 Epithelial epithelial JJ cord-007796-zggk0x2q 171 2 NF NF NNP cord-007796-zggk0x2q 171 3 - - HYPH cord-007796-zggk0x2q 171 4 kB kB NNP cord-007796-zggk0x2q 171 5 activation activation NN cord-007796-zggk0x2q 171 6 has have VBZ cord-007796-zggk0x2q 171 7 also also RB cord-007796-zggk0x2q 171 8 been be VBN cord-007796-zggk0x2q 171 9 observed observe VBN cord-007796-zggk0x2q 171 10 in in IN cord-007796-zggk0x2q 171 11 other other JJ cord-007796-zggk0x2q 171 12 viral viral JJ cord-007796-zggk0x2q 171 13 infections infection NNS cord-007796-zggk0x2q 171 14 , , , cord-007796-zggk0x2q 171 15 including include VBG cord-007796-zggk0x2q 171 16 parainfluenza parainfluenza NNP cord-007796-zggk0x2q 171 17 , , , cord-007796-zggk0x2q 171 18 influenza influenza NN cord-007796-zggk0x2q 171 19 A A NNP cord-007796-zggk0x2q 171 20 , , , cord-007796-zggk0x2q 171 21 and and CC cord-007796-zggk0x2q 171 22 rhinovirus rhinovirus NN cord-007796-zggk0x2q 171 23 ( ( -LRB- cord-007796-zggk0x2q 171 24 Pahl Pahl NNP cord-007796-zggk0x2q 171 25 and and CC cord-007796-zggk0x2q 171 26 Baeuerle Baeuerle NNP cord-007796-zggk0x2q 171 27 , , , cord-007796-zggk0x2q 171 28 1995 1995 CD cord-007796-zggk0x2q 171 29 ; ; : cord-007796-zggk0x2q 171 30 Kim Kim NNP cord-007796-zggk0x2q 171 31 et et NNP cord-007796-zggk0x2q 171 32 al al NNP cord-007796-zggk0x2q 171 33 . . . cord-007796-zggk0x2q 172 1 , , , cord-007796-zggk0x2q 172 2 2000 2000 CD cord-007796-zggk0x2q 172 3 ; ; : cord-007796-zggk0x2q 172 4 Bose Bose NNP cord-007796-zggk0x2q 172 5 et et NNP cord-007796-zggk0x2q 172 6 al al NNP cord-007796-zggk0x2q 172 7 . . NNP cord-007796-zggk0x2q 172 8 , , , cord-007796-zggk0x2q 172 9 2003 2003 CD cord-007796-zggk0x2q 172 10 ) ) -RRB- cord-007796-zggk0x2q 172 11 . . . cord-007796-zggk0x2q 173 1 NF NF NNP cord-007796-zggk0x2q 173 2 - - HYPH cord-007796-zggk0x2q 173 3 kB kB NNP cord-007796-zggk0x2q 173 4 could could MD cord-007796-zggk0x2q 173 5 be be VB cord-007796-zggk0x2q 173 6 an an DT cord-007796-zggk0x2q 173 7 exciting exciting JJ cord-007796-zggk0x2q 173 8 target target NN cord-007796-zggk0x2q 173 9 for for IN cord-007796-zggk0x2q 173 10 therapy therapy NN cord-007796-zggk0x2q 173 11 development development NN cord-007796-zggk0x2q 173 12 and and CC cord-007796-zggk0x2q 173 13 experiments experiment NNS cord-007796-zggk0x2q 173 14 in in IN cord-007796-zggk0x2q 173 15 which which WDT cord-007796-zggk0x2q 173 16 BALB BALB NNP cord-007796-zggk0x2q 173 17 / / SYM cord-007796-zggk0x2q 173 18 c c NN cord-007796-zggk0x2q 173 19 mice mouse NNS cord-007796-zggk0x2q 173 20 were be VBD cord-007796-zggk0x2q 173 21 treated treat VBN cord-007796-zggk0x2q 173 22 with with IN cord-007796-zggk0x2q 173 23 perflubron perflubron NNP cord-007796-zggk0x2q 173 24 have have VBP cord-007796-zggk0x2q 173 25 confirmed confirm VBN cord-007796-zggk0x2q 173 26 this this DT cord-007796-zggk0x2q 173 27 concept concept NN cord-007796-zggk0x2q 173 28 . . . cord-007796-zggk0x2q 174 1 Perflubron Perflubron NNP cord-007796-zggk0x2q 174 2 has have VBZ cord-007796-zggk0x2q 174 3 already already RB cord-007796-zggk0x2q 174 4 been be VBN cord-007796-zggk0x2q 174 5 shown show VBN cord-007796-zggk0x2q 174 6 to to TO cord-007796-zggk0x2q 174 7 be be VB cord-007796-zggk0x2q 174 8 effective effective JJ cord-007796-zggk0x2q 174 9 in in IN cord-007796-zggk0x2q 174 10 clinical clinical JJ cord-007796-zggk0x2q 174 11 trials trial NNS cord-007796-zggk0x2q 174 12 of of IN cord-007796-zggk0x2q 174 13 patients patient NNS cord-007796-zggk0x2q 174 14 with with IN cord-007796-zggk0x2q 174 15 respiratory respiratory JJ cord-007796-zggk0x2q 174 16 distress distress NN cord-007796-zggk0x2q 174 17 syndrome syndrome NN cord-007796-zggk0x2q 174 18 because because IN cord-007796-zggk0x2q 174 19 of of IN cord-007796-zggk0x2q 174 20 its -PRON- PRP$ cord-007796-zggk0x2q 174 21 physical physical JJ cord-007796-zggk0x2q 174 22 characteristics characteristic NNS cord-007796-zggk0x2q 174 23 . . . cord-007796-zggk0x2q 175 1 Besides besides IN cord-007796-zggk0x2q 175 2 the the DT cord-007796-zggk0x2q 175 3 beneficial beneficial JJ cord-007796-zggk0x2q 175 4 physical physical JJ cord-007796-zggk0x2q 175 5 effect effect NN cord-007796-zggk0x2q 175 6 in in IN cord-007796-zggk0x2q 175 7 improvement improvement NN cord-007796-zggk0x2q 175 8 of of IN cord-007796-zggk0x2q 175 9 gas gas NN cord-007796-zggk0x2q 175 10 exchange exchange NN cord-007796-zggk0x2q 175 11 and and CC cord-007796-zggk0x2q 175 12 of of IN cord-007796-zggk0x2q 175 13 lung lung NN cord-007796-zggk0x2q 175 14 compliance compliance NN cord-007796-zggk0x2q 175 15 , , , cord-007796-zggk0x2q 175 16 this this DT cord-007796-zggk0x2q 175 17 agent agent NN cord-007796-zggk0x2q 175 18 was be VBD cord-007796-zggk0x2q 175 19 found find VBN cord-007796-zggk0x2q 175 20 to to TO cord-007796-zggk0x2q 175 21 have have VB cord-007796-zggk0x2q 175 22 anti anti JJ cord-007796-zggk0x2q 175 23 - - JJ cord-007796-zggk0x2q 175 24 inflammatory inflammatory JJ cord-007796-zggk0x2q 175 25 effects effect NNS cord-007796-zggk0x2q 175 26 . . . cord-007796-zggk0x2q 176 1 RSV RSV NNP cord-007796-zggk0x2q 176 2 - - HYPH cord-007796-zggk0x2q 176 3 infected infect VBN cord-007796-zggk0x2q 176 4 BALB BALB NNP cord-007796-zggk0x2q 176 5 / / SYM cord-007796-zggk0x2q 176 6 c c NN cord-007796-zggk0x2q 176 7 mice mouse NNS cord-007796-zggk0x2q 176 8 treated treat VBN cord-007796-zggk0x2q 176 9 with with IN cord-007796-zggk0x2q 176 10 perflubron perflubron NNP cord-007796-zggk0x2q 176 11 intranasally intranasally RB cord-007796-zggk0x2q 176 12 showed show VBD cord-007796-zggk0x2q 176 13 a a DT cord-007796-zggk0x2q 176 14 reduction reduction NN cord-007796-zggk0x2q 176 15 in in IN cord-007796-zggk0x2q 176 16 cellular cellular JJ cord-007796-zggk0x2q 176 17 inflammatory inflammatory JJ cord-007796-zggk0x2q 176 18 infiltrates infiltrate NNS cord-007796-zggk0x2q 176 19 and and CC cord-007796-zggk0x2q 176 20 decreased decrease VBD cord-007796-zggk0x2q 176 21 chemokine chemokine JJ cord-007796-zggk0x2q 176 22 expression expression NN cord-007796-zggk0x2q 176 23 in in IN cord-007796-zggk0x2q 176 24 the the DT cord-007796-zggk0x2q 176 25 lung lung NN cord-007796-zggk0x2q 176 26 tissue tissue NN cord-007796-zggk0x2q 176 27 . . . cord-007796-zggk0x2q 177 1 Both both DT cord-007796-zggk0x2q 177 2 the the DT cord-007796-zggk0x2q 177 3 anti anti JJ cord-007796-zggk0x2q 177 4 - - JJ cord-007796-zggk0x2q 177 5 inflammatory inflammatory JJ cord-007796-zggk0x2q 177 6 effects effect NNS cord-007796-zggk0x2q 177 7 were be VBD cord-007796-zggk0x2q 177 8 directly directly RB cord-007796-zggk0x2q 177 9 linked link VBN cord-007796-zggk0x2q 177 10 to to IN cord-007796-zggk0x2q 177 11 interference interference NN cord-007796-zggk0x2q 177 12 of of IN cord-007796-zggk0x2q 177 13 perflubron perflubron NN cord-007796-zggk0x2q 177 14 with with IN cord-007796-zggk0x2q 177 15 NF NF NNP cord-007796-zggk0x2q 177 16 - - HYPH cord-007796-zggk0x2q 177 17 kB kB NNP cord-007796-zggk0x2q 177 18 - - HYPH cord-007796-zggk0x2q 177 19 mediated mediate VBN cord-007796-zggk0x2q 177 20 transcription transcription NN cord-007796-zggk0x2q 178 1 ( ( -LRB- cord-007796-zggk0x2q 178 2 Haeberle Haeberle NNP cord-007796-zggk0x2q 178 3 et et NNP cord-007796-zggk0x2q 178 4 al al NNP cord-007796-zggk0x2q 178 5 . . NNP cord-007796-zggk0x2q 178 6 , , , cord-007796-zggk0x2q 178 7 2002a 2002a CD cord-007796-zggk0x2q 178 8 , , , cord-007796-zggk0x2q 178 9 b b LS cord-007796-zggk0x2q 178 10 ) ) -RRB- cord-007796-zggk0x2q 178 11 . . . cord-007796-zggk0x2q 179 1 The the DT cord-007796-zggk0x2q 179 2 chemokines chemokine NNS cord-007796-zggk0x2q 179 3 produced produce VBN cord-007796-zggk0x2q 179 4 by by IN cord-007796-zggk0x2q 179 5 epithelial epithelial JJ cord-007796-zggk0x2q 179 6 cells cell NNS cord-007796-zggk0x2q 179 7 attract attract VBP cord-007796-zggk0x2q 179 8 T t NN cord-007796-zggk0x2q 179 9 - - HYPH cord-007796-zggk0x2q 179 10 cells cell NNS cord-007796-zggk0x2q 179 11 , , , cord-007796-zggk0x2q 179 12 neutrophils neutrophil NNS cord-007796-zggk0x2q 179 13 , , , cord-007796-zggk0x2q 179 14 monocytes monocyte NNS cord-007796-zggk0x2q 179 15 , , , cord-007796-zggk0x2q 179 16 and and CC cord-007796-zggk0x2q 179 17 possibly possibly RB cord-007796-zggk0x2q 179 18 eosinophils eosinophil VBZ cord-007796-zggk0x2q 179 19 to to IN cord-007796-zggk0x2q 179 20 the the DT cord-007796-zggk0x2q 179 21 respiratory respiratory JJ cord-007796-zggk0x2q 179 22 tract tract NN cord-007796-zggk0x2q 179 23 . . . cord-007796-zggk0x2q 180 1 Besides besides IN cord-007796-zggk0x2q 180 2 induction induction NN cord-007796-zggk0x2q 180 3 of of IN cord-007796-zggk0x2q 180 4 secreted secrete VBN cord-007796-zggk0x2q 180 5 products product NNS cord-007796-zggk0x2q 180 6 , , , cord-007796-zggk0x2q 180 7 epithelial epithelial JJ cord-007796-zggk0x2q 180 8 cells cell NNS cord-007796-zggk0x2q 180 9 upregulate upregulate VBP cord-007796-zggk0x2q 180 10 expression expression NN cord-007796-zggk0x2q 180 11 of of IN cord-007796-zggk0x2q 180 12 adhesion adhesion NN cord-007796-zggk0x2q 180 13 molecules molecule NNS cord-007796-zggk0x2q 180 14 for for IN cord-007796-zggk0x2q 180 15 neutrophils neutrophil NNS cord-007796-zggk0x2q 180 16 on on IN cord-007796-zggk0x2q 180 17 their -PRON- PRP$ cord-007796-zggk0x2q 180 18 surface surface NN cord-007796-zggk0x2q 180 19 , , , cord-007796-zggk0x2q 180 20 allowing allow VBG cord-007796-zggk0x2q 180 21 neutrophils neutrophil NNS cord-007796-zggk0x2q 180 22 to to TO cord-007796-zggk0x2q 180 23 adhere adhere VB cord-007796-zggk0x2q 180 24 firmly firmly RB cord-007796-zggk0x2q 180 25 to to IN cord-007796-zggk0x2q 180 26 infected infected JJ cord-007796-zggk0x2q 180 27 cells cell NNS cord-007796-zggk0x2q 180 28 ( ( -LRB- cord-007796-zggk0x2q 180 29 Wang Wang NNP cord-007796-zggk0x2q 180 30 and and CC cord-007796-zggk0x2q 180 31 Forsyth Forsyth NNP cord-007796-zggk0x2q 180 32 , , , cord-007796-zggk0x2q 180 33 2000 2000 CD cord-007796-zggk0x2q 180 34 ) ) -RRB- cord-007796-zggk0x2q 180 35 . . . cord-007796-zggk0x2q 181 1 Furthermore furthermore RB cord-007796-zggk0x2q 181 2 , , , cord-007796-zggk0x2q 181 3 neutrophils neutrophil NNS cord-007796-zggk0x2q 181 4 are be VBP cord-007796-zggk0x2q 181 5 the the DT cord-007796-zggk0x2q 181 6 dominant dominant JJ cord-007796-zggk0x2q 181 7 cell cell NN cord-007796-zggk0x2q 181 8 type type NN cord-007796-zggk0x2q 181 9 found find VBN cord-007796-zggk0x2q 181 10 in in IN cord-007796-zggk0x2q 181 11 bronchoalveolar bronchoalveolar NNP cord-007796-zggk0x2q 181 12 lavage lavage NNP cord-007796-zggk0x2q 181 13 ( ( -LRB- cord-007796-zggk0x2q 181 14 BAL BAL NNP cord-007796-zggk0x2q 181 15 ) ) -RRB- cord-007796-zggk0x2q 181 16 fluid fluid NN cord-007796-zggk0x2q 181 17 of of IN cord-007796-zggk0x2q 181 18 RSV RSV NNP cord-007796-zggk0x2q 181 19 patients patient NNS cord-007796-zggk0x2q 181 20 ( ( -LRB- cord-007796-zggk0x2q 181 21 Everard Everard NNP cord-007796-zggk0x2q 181 22 et et NNP cord-007796-zggk0x2q 181 23 al al NNP cord-007796-zggk0x2q 181 24 . . NNP cord-007796-zggk0x2q 181 25 , , , cord-007796-zggk0x2q 181 26 1994 1994 CD cord-007796-zggk0x2q 181 27 . . . cord-007796-zggk0x2q 182 1 However however RB cord-007796-zggk0x2q 182 2 , , , cord-007796-zggk0x2q 182 3 their -PRON- PRP$ cord-007796-zggk0x2q 182 4 role role NN cord-007796-zggk0x2q 182 5 in in IN cord-007796-zggk0x2q 182 6 fighting fight VBG cord-007796-zggk0x2q 182 7 viral viral JJ cord-007796-zggk0x2q 182 8 infection infection NN cord-007796-zggk0x2q 182 9 is be VBZ cord-007796-zggk0x2q 182 10 not not RB cord-007796-zggk0x2q 182 11 as as RB cord-007796-zggk0x2q 182 12 well well RB cord-007796-zggk0x2q 182 13 established establish VBN cord-007796-zggk0x2q 182 14 as as IN cord-007796-zggk0x2q 182 15 in in IN cord-007796-zggk0x2q 182 16 bacterial bacterial JJ cord-007796-zggk0x2q 182 17 infections infection NNS cord-007796-zggk0x2q 182 18 . . . cord-007796-zggk0x2q 183 1 Pathological pathological JJ cord-007796-zggk0x2q 183 2 studies study NNS cord-007796-zggk0x2q 183 3 of of IN cord-007796-zggk0x2q 183 4 lungs lung NNS cord-007796-zggk0x2q 183 5 of of IN cord-007796-zggk0x2q 183 6 RSV RSV NNP cord-007796-zggk0x2q 183 7 - - HYPH cord-007796-zggk0x2q 183 8 infected infect VBN cord-007796-zggk0x2q 183 9 calves calf NNS cord-007796-zggk0x2q 183 10 have have VBP cord-007796-zggk0x2q 183 11 shown show VBN cord-007796-zggk0x2q 183 12 a a DT cord-007796-zggk0x2q 183 13 major major JJ cord-007796-zggk0x2q 183 14 influx influx NN cord-007796-zggk0x2q 183 15 of of IN cord-007796-zggk0x2q 183 16 neutrophils neutrophil NNS cord-007796-zggk0x2q 183 17 in in IN cord-007796-zggk0x2q 183 18 the the DT cord-007796-zggk0x2q 183 19 infected infected JJ cord-007796-zggk0x2q 183 20 airway airway NN cord-007796-zggk0x2q 183 21 mucosa mucosa NN cord-007796-zggk0x2q 183 22 , , , cord-007796-zggk0x2q 183 23 observed observe VBD cord-007796-zggk0x2q 183 24 earlier early RBR cord-007796-zggk0x2q 183 25 than than IN cord-007796-zggk0x2q 183 26 any any DT cord-007796-zggk0x2q 183 27 other other JJ cord-007796-zggk0x2q 183 28 cell cell NN cord-007796-zggk0x2q 183 29 type type NN cord-007796-zggk0x2q 183 30 involved involve VBN cord-007796-zggk0x2q 183 31 . . . cord-007796-zggk0x2q 184 1 Furthermore furthermore RB cord-007796-zggk0x2q 184 2 , , , cord-007796-zggk0x2q 184 3 neutrophils neutrophil NNS cord-007796-zggk0x2q 184 4 are be VBP cord-007796-zggk0x2q 184 5 the the DT cord-007796-zggk0x2q 184 6 dominant dominant JJ cord-007796-zggk0x2q 184 7 cell cell NN cord-007796-zggk0x2q 184 8 type type NN cord-007796-zggk0x2q 184 9 found find VBN cord-007796-zggk0x2q 184 10 in in IN cord-007796-zggk0x2q 184 11 bronchoalveolar bronchoalveolar NNP cord-007796-zggk0x2q 184 12 lavage lavage NNP cord-007796-zggk0x2q 184 13 ( ( -LRB- cord-007796-zggk0x2q 184 14 BAL BAL NNP cord-007796-zggk0x2q 184 15 ) ) -RRB- cord-007796-zggk0x2q 184 16 fluid fluid NN cord-007796-zggk0x2q 184 17 of of IN cord-007796-zggk0x2q 184 18 RSV RSV NNP cord-007796-zggk0x2q 184 19 patients patient NNS cord-007796-zggk0x2q 184 20 ( ( -LRB- cord-007796-zggk0x2q 184 21 Everard Everard NNP cord-007796-zggk0x2q 184 22 et et NNP cord-007796-zggk0x2q 184 23 al al NNP cord-007796-zggk0x2q 184 24 . . NNP cord-007796-zggk0x2q 184 25 , , , cord-007796-zggk0x2q 184 26 1994 1994 CD cord-007796-zggk0x2q 184 27 " " '' cord-007796-zggk0x2q 185 1 Several several JJ cord-007796-zggk0x2q 185 2 chemokines chemokine NNS cord-007796-zggk0x2q 185 3 and and CC cord-007796-zggk0x2q 185 4 cytokines cytokine NNS cord-007796-zggk0x2q 185 5 involved involve VBN cord-007796-zggk0x2q 185 6 in in IN cord-007796-zggk0x2q 185 7 neutrophil neutrophil NN cord-007796-zggk0x2q 185 8 activation activation NN cord-007796-zggk0x2q 185 9 have have VBP cord-007796-zggk0x2q 185 10 been be VBN cord-007796-zggk0x2q 185 11 associated associate VBN cord-007796-zggk0x2q 185 12 with with IN cord-007796-zggk0x2q 185 13 RSV RSV NNP cord-007796-zggk0x2q 185 14 lower low JJR cord-007796-zggk0x2q 185 15 respiratory respiratory JJ cord-007796-zggk0x2q 185 16 tract tract NN cord-007796-zggk0x2q 185 17 infections infection NNS cord-007796-zggk0x2q 185 18 . . . cord-007796-zggk0x2q 186 1 Recently recently RB cord-007796-zggk0x2q 186 2 , , , cord-007796-zggk0x2q 186 3 local local JJ cord-007796-zggk0x2q 186 4 neutrophil neutrophil NN cord-007796-zggk0x2q 186 5 IL-9 IL-9 NNP cord-007796-zggk0x2q 186 6 production production NN cord-007796-zggk0x2q 186 7 has have VBZ cord-007796-zggk0x2q 186 8 been be VBN cord-007796-zggk0x2q 186 9 linked link VBN cord-007796-zggk0x2q 186 10 to to IN cord-007796-zggk0x2q 186 11 RSV RSV NNP cord-007796-zggk0x2q 186 12 bronchiolitis bronchiolitis NNP cord-007796-zggk0x2q 186 13 ( ( -LRB- cord-007796-zggk0x2q 186 14 McNamara McNamara NNP cord-007796-zggk0x2q 186 15 et et NNP cord-007796-zggk0x2q 186 16 al al NNP cord-007796-zggk0x2q 186 17 . . NNP cord-007796-zggk0x2q 186 18 , , , cord-007796-zggk0x2q 186 19 2004 2004 CD cord-007796-zggk0x2q 186 20 ) ) -RRB- cord-007796-zggk0x2q 186 21 . . . cord-007796-zggk0x2q 187 1 As as IN cord-007796-zggk0x2q 187 2 shown show VBN cord-007796-zggk0x2q 187 3 by by IN cord-007796-zggk0x2q 187 4 Wang Wang NNP cord-007796-zggk0x2q 187 5 et et NNP cord-007796-zggk0x2q 187 6 al al NNP cord-007796-zggk0x2q 187 7 . . NNP cord-007796-zggk0x2q 187 8 , , , cord-007796-zggk0x2q 187 9 a a DT cord-007796-zggk0x2q 187 10 major major JJ cord-007796-zggk0x2q 187 11 increase increase NN cord-007796-zggk0x2q 187 12 in in IN cord-007796-zggk0x2q 187 13 epithelial epithelial JJ cord-007796-zggk0x2q 187 14 damage damage NN cord-007796-zggk0x2q 187 15 occurs occur VBZ cord-007796-zggk0x2q 187 16 , , , cord-007796-zggk0x2q 187 17 when when WRB cord-007796-zggk0x2q 187 18 RSVinfected rsvinfected JJ cord-007796-zggk0x2q 187 19 epithelial epithelial JJ cord-007796-zggk0x2q 187 20 cells cell NNS cord-007796-zggk0x2q 187 21 are be VBP cord-007796-zggk0x2q 187 22 co co JJ cord-007796-zggk0x2q 187 23 - - JJ cord-007796-zggk0x2q 187 24 cultured cultured JJ cord-007796-zggk0x2q 187 25 with with IN cord-007796-zggk0x2q 187 26 neutrophils neutrophil NNS cord-007796-zggk0x2q 187 27 ( ( -LRB- cord-007796-zggk0x2q 187 28 Wang Wang NNP cord-007796-zggk0x2q 187 29 and and CC cord-007796-zggk0x2q 187 30 Forsyth Forsyth NNP cord-007796-zggk0x2q 187 31 , , , cord-007796-zggk0x2q 187 32 2000 2000 CD cord-007796-zggk0x2q 187 33 ) ) -RRB- cord-007796-zggk0x2q 187 34 . . . cord-007796-zggk0x2q 188 1 This this DT cord-007796-zggk0x2q 188 2 is be VBZ cord-007796-zggk0x2q 188 3 suggestive suggestive JJ cord-007796-zggk0x2q 188 4 of of IN cord-007796-zggk0x2q 188 5 a a DT cord-007796-zggk0x2q 188 6 detrimental detrimental JJ cord-007796-zggk0x2q 188 7 role role NN cord-007796-zggk0x2q 188 8 for for IN cord-007796-zggk0x2q 188 9 neutrophil neutrophil NN cord-007796-zggk0x2q 188 10 - - HYPH cord-007796-zggk0x2q 188 11 induced induce VBN cord-007796-zggk0x2q 188 12 immunopathology immunopathology NN cord-007796-zggk0x2q 188 13 in in IN cord-007796-zggk0x2q 188 14 lower low JJR cord-007796-zggk0x2q 188 15 respiratory respiratory JJ cord-007796-zggk0x2q 188 16 tract tract NN cord-007796-zggk0x2q 188 17 infections infection NNS cord-007796-zggk0x2q 188 18 . . . cord-007796-zggk0x2q 189 1 RANTES RANTES NNP cord-007796-zggk0x2q 189 2 and and CC cord-007796-zggk0x2q 189 3 MIP-1 MIP-1 NNP cord-007796-zggk0x2q 190 1 ␣ ␣ NNP cord-007796-zggk0x2q 190 2 are be VBP cord-007796-zggk0x2q 190 3 produced produce VBN cord-007796-zggk0x2q 190 4 by by IN cord-007796-zggk0x2q 190 5 the the DT cord-007796-zggk0x2q 190 6 epithelium epithelium NN cord-007796-zggk0x2q 190 7 in in IN cord-007796-zggk0x2q 190 8 response response NN cord-007796-zggk0x2q 190 9 to to IN cord-007796-zggk0x2q 190 10 RSV RSV NNP cord-007796-zggk0x2q 190 11 infection infection NN cord-007796-zggk0x2q 190 12 and and CC cord-007796-zggk0x2q 190 13 these these DT cord-007796-zggk0x2q 190 14 chemoattractants chemoattractant NNS cord-007796-zggk0x2q 190 15 recruit recruit VBP cord-007796-zggk0x2q 190 16 eosinophils eosinophil NNS cord-007796-zggk0x2q 190 17 to to IN cord-007796-zggk0x2q 190 18 the the DT cord-007796-zggk0x2q 190 19 inflammatory inflammatory JJ cord-007796-zggk0x2q 190 20 site site NN cord-007796-zggk0x2q 190 21 . . . cord-007796-zggk0x2q 191 1 The the DT cord-007796-zggk0x2q 191 2 analogy analogy NN cord-007796-zggk0x2q 191 3 between between IN cord-007796-zggk0x2q 191 4 clinical clinical JJ cord-007796-zggk0x2q 191 5 features feature NNS cord-007796-zggk0x2q 191 6 of of IN cord-007796-zggk0x2q 191 7 virus virus NN cord-007796-zggk0x2q 191 8 - - HYPH cord-007796-zggk0x2q 191 9 induced induce VBN cord-007796-zggk0x2q 191 10 wheezing wheeze VBG cord-007796-zggk0x2q 191 11 illnesses illness NNS cord-007796-zggk0x2q 191 12 and and CC cord-007796-zggk0x2q 191 13 asthma asthma NN cord-007796-zggk0x2q 191 14 has have VBZ cord-007796-zggk0x2q 191 15 made make VBN cord-007796-zggk0x2q 191 16 eosinophils eosinophil NNS cord-007796-zggk0x2q 191 17 an an DT cord-007796-zggk0x2q 191 18 attractive attractive JJ cord-007796-zggk0x2q 191 19 subject subject NN cord-007796-zggk0x2q 191 20 for for IN cord-007796-zggk0x2q 191 21 studies study NNS cord-007796-zggk0x2q 191 22 aimed aim VBN cord-007796-zggk0x2q 191 23 at at IN cord-007796-zggk0x2q 191 24 improving improve VBG cord-007796-zggk0x2q 191 25 understanding understanding NN cord-007796-zggk0x2q 191 26 of of IN cord-007796-zggk0x2q 191 27 RSV RSV NNP cord-007796-zggk0x2q 191 28 pathogenesis pathogenesis NN cord-007796-zggk0x2q 191 29 . . . cord-007796-zggk0x2q 192 1 However however RB cord-007796-zggk0x2q 192 2 , , , cord-007796-zggk0x2q 192 3 mainly mainly RB cord-007796-zggk0x2q 192 4 because because IN cord-007796-zggk0x2q 192 5 of of IN cord-007796-zggk0x2q 192 6 their -PRON- PRP$ cord-007796-zggk0x2q 192 7 absence absence NN cord-007796-zggk0x2q 192 8 in in IN cord-007796-zggk0x2q 192 9 BAL BAL NNP cord-007796-zggk0x2q 192 10 of of IN cord-007796-zggk0x2q 192 11 RSV RSV NNP cord-007796-zggk0x2q 192 12 patients patient NNS cord-007796-zggk0x2q 192 13 , , , cord-007796-zggk0x2q 192 14 their -PRON- PRP$ cord-007796-zggk0x2q 192 15 involvement involvement NN cord-007796-zggk0x2q 192 16 remains remain VBZ cord-007796-zggk0x2q 192 17 controversial controversial JJ cord-007796-zggk0x2q 192 18 . . . cord-007796-zggk0x2q 193 1 However however RB cord-007796-zggk0x2q 193 2 , , , cord-007796-zggk0x2q 193 3 eosinophil eosinophil RB cord-007796-zggk0x2q 193 4 - - HYPH cord-007796-zggk0x2q 193 5 derived derive VBN cord-007796-zggk0x2q 193 6 cationic cationic JJ cord-007796-zggk0x2q 193 7 protein protein NN cord-007796-zggk0x2q 193 8 ( ( -LRB- cord-007796-zggk0x2q 193 9 ECP ECP NNP cord-007796-zggk0x2q 193 10 ) ) -RRB- cord-007796-zggk0x2q 193 11 has have VBZ cord-007796-zggk0x2q 193 12 been be VBN cord-007796-zggk0x2q 193 13 linked link VBN cord-007796-zggk0x2q 193 14 to to IN cord-007796-zggk0x2q 193 15 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 193 16 and and CC cord-007796-zggk0x2q 193 17 postbronchiolitic postbronchiolitic JJ cord-007796-zggk0x2q 193 18 wheezing wheeze VBG cord-007796-zggk0x2q 193 19 Pifferi Pifferi NNP cord-007796-zggk0x2q 193 20 et et NNP cord-007796-zggk0x2q 193 21 al al NNP cord-007796-zggk0x2q 193 22 . . . cord-007796-zggk0x2q 194 1 , , , cord-007796-zggk0x2q 194 2 2001 2001 CD cord-007796-zggk0x2q 194 3 ; ; : cord-007796-zggk0x2q 194 4 Dimova Dimova NNP cord-007796-zggk0x2q 194 5 - - HYPH cord-007796-zggk0x2q 194 6 Yaneva Yaneva NNP cord-007796-zggk0x2q 194 7 et et NNP cord-007796-zggk0x2q 194 8 al al NNP cord-007796-zggk0x2q 194 9 . . NNP cord-007796-zggk0x2q 194 10 , , , cord-007796-zggk0x2q 194 11 2004 2004 CD cord-007796-zggk0x2q 194 12 ) ) -RRB- cord-007796-zggk0x2q 194 13 . . . cord-007796-zggk0x2q 195 1 In in IN cord-007796-zggk0x2q 195 2 vitro vitro FW cord-007796-zggk0x2q 195 3 , , , cord-007796-zggk0x2q 195 4 eosinophils eosinophil NNS cord-007796-zggk0x2q 195 5 have have VBP cord-007796-zggk0x2q 195 6 also also RB cord-007796-zggk0x2q 195 7 been be VBN cord-007796-zggk0x2q 195 8 shown show VBN cord-007796-zggk0x2q 195 9 to to TO cord-007796-zggk0x2q 195 10 be be VB cord-007796-zggk0x2q 195 11 susceptible susceptible JJ cord-007796-zggk0x2q 195 12 to to IN cord-007796-zggk0x2q 195 13 RSV RSV NNP cord-007796-zggk0x2q 195 14 . . . cord-007796-zggk0x2q 196 1 Eosinophil eosinophil JJ cord-007796-zggk0x2q 196 2 priming priming NN cord-007796-zggk0x2q 196 3 , , , cord-007796-zggk0x2q 196 4 superoxide superoxide NN cord-007796-zggk0x2q 196 5 production production NN cord-007796-zggk0x2q 196 6 , , , cord-007796-zggk0x2q 196 7 and and CC cord-007796-zggk0x2q 196 8 degranulation degranulation NN cord-007796-zggk0x2q 196 9 were be VBD cord-007796-zggk0x2q 196 10 induced induce VBN cord-007796-zggk0x2q 196 11 by by IN cord-007796-zggk0x2q 196 12 incubation incubation NN cord-007796-zggk0x2q 196 13 with with IN cord-007796-zggk0x2q 196 14 RSV RSV NNP cord-007796-zggk0x2q 196 15 Kimpen Kimpen NNP cord-007796-zggk0x2q 196 16 et et FW cord-007796-zggk0x2q 196 17 al al NNP cord-007796-zggk0x2q 196 18 . . NNP cord-007796-zggk0x2q 196 19 , , , cord-007796-zggk0x2q 196 20 1992 1992 CD cord-007796-zggk0x2q 196 21 ; ; : cord-007796-zggk0x2q 196 22 Olszewska Olszewska NNP cord-007796-zggk0x2q 196 23 - - HYPH cord-007796-zggk0x2q 196 24 Pazdrak Pazdrak NNP cord-007796-zggk0x2q 196 25 et et NNP cord-007796-zggk0x2q 196 26 al al NNP cord-007796-zggk0x2q 196 27 . . NNP cord-007796-zggk0x2q 196 28 , , , cord-007796-zggk0x2q 196 29 1998 1998 CD cord-007796-zggk0x2q 196 30 ; ; : cord-007796-zggk0x2q 196 31 Tachibana Tachibana NNP cord-007796-zggk0x2q 196 32 et et NNP cord-007796-zggk0x2q 196 33 al al NNP cord-007796-zggk0x2q 196 34 . . NNP cord-007796-zggk0x2q 196 35 , , , cord-007796-zggk0x2q 196 36 2002 2002 CD cord-007796-zggk0x2q 196 37 ) ) -RRB- cord-007796-zggk0x2q 196 38 . . . cord-007796-zggk0x2q 197 1 Rosenberg Rosenberg NNP cord-007796-zggk0x2q 197 2 and and CC cord-007796-zggk0x2q 197 3 Domachowske Domachowske NNP cord-007796-zggk0x2q 197 4 ( ( -LRB- cord-007796-zggk0x2q 197 5 2001 2001 CD cord-007796-zggk0x2q 197 6 ) ) -RRB- cord-007796-zggk0x2q 197 7 have have VBP cord-007796-zggk0x2q 197 8 suggested suggest VBN cord-007796-zggk0x2q 197 9 a a DT cord-007796-zggk0x2q 197 10 beneficial beneficial JJ cord-007796-zggk0x2q 197 11 role role NN cord-007796-zggk0x2q 197 12 for for IN cord-007796-zggk0x2q 197 13 eosinophils eosinophil NNS cord-007796-zggk0x2q 197 14 in in IN cord-007796-zggk0x2q 197 15 RSV RSV NNP cord-007796-zggk0x2q 197 16 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 197 17 . . . cord-007796-zggk0x2q 198 1 They -PRON- PRP cord-007796-zggk0x2q 198 2 identified identify VBD cord-007796-zggk0x2q 198 3 antiviral antiviral JJ cord-007796-zggk0x2q 198 4 properties property NNS cord-007796-zggk0x2q 198 5 for for IN cord-007796-zggk0x2q 198 6 the the DT cord-007796-zggk0x2q 198 7 eosinophil eosinophil NN cord-007796-zggk0x2q 198 8 based base VBN cord-007796-zggk0x2q 198 9 on on IN cord-007796-zggk0x2q 198 10 ribonuclease ribonuclease NN cord-007796-zggk0x2q 198 11 activity activity NN cord-007796-zggk0x2q 198 12 of of IN cord-007796-zggk0x2q 198 13 eosinophil eosinophil RB cord-007796-zggk0x2q 198 14 - - HYPH cord-007796-zggk0x2q 198 15 derived derive VBN cord-007796-zggk0x2q 198 16 neurotoxin neurotoxin NN cord-007796-zggk0x2q 198 17 ( ( -LRB- cord-007796-zggk0x2q 198 18 EDN EDN NNP cord-007796-zggk0x2q 198 19 ) ) -RRB- cord-007796-zggk0x2q 198 20 and and CC cord-007796-zggk0x2q 198 21 ECP ECP NNP cord-007796-zggk0x2q 198 22 . . . cord-007796-zggk0x2q 199 1 This this DT cord-007796-zggk0x2q 199 2 enzymatic enzymatic JJ cord-007796-zggk0x2q 199 3 activity activity NN cord-007796-zggk0x2q 199 4 leads lead VBZ cord-007796-zggk0x2q 199 5 to to IN cord-007796-zggk0x2q 199 6 destruction destruction NN cord-007796-zggk0x2q 199 7 of of IN cord-007796-zggk0x2q 199 8 extracellular extracellular JJ cord-007796-zggk0x2q 199 9 ssRNA ssrna NN cord-007796-zggk0x2q 199 10 virions virion NNS cord-007796-zggk0x2q 199 11 and and CC cord-007796-zggk0x2q 199 12 delayed delay VBN cord-007796-zggk0x2q 199 13 replication replication NN cord-007796-zggk0x2q 199 14 both both CC cord-007796-zggk0x2q 199 15 in in IN cord-007796-zggk0x2q 199 16 vitro vitro FW cord-007796-zggk0x2q 199 17 and and CC cord-007796-zggk0x2q 199 18 in in IN cord-007796-zggk0x2q 199 19 vivo vivo NNP cord-007796-zggk0x2q 199 20 . . . cord-007796-zggk0x2q 200 1 Recently recently RB cord-007796-zggk0x2q 200 2 , , , cord-007796-zggk0x2q 200 3 there there EX cord-007796-zggk0x2q 200 4 has have VBZ cord-007796-zggk0x2q 200 5 also also RB cord-007796-zggk0x2q 200 6 been be VBN cord-007796-zggk0x2q 200 7 great great JJ cord-007796-zggk0x2q 200 8 interest interest NN cord-007796-zggk0x2q 200 9 in in IN cord-007796-zggk0x2q 200 10 the the DT cord-007796-zggk0x2q 200 11 involvement involvement NN cord-007796-zggk0x2q 200 12 of of IN cord-007796-zggk0x2q 200 13 macrophages macrophage NNS cord-007796-zggk0x2q 200 14 and and CC cord-007796-zggk0x2q 200 15 dendritic dendritic JJ cord-007796-zggk0x2q 200 16 cells cell NNS cord-007796-zggk0x2q 200 17 in in IN cord-007796-zggk0x2q 200 18 RSV RSV NNP cord-007796-zggk0x2q 200 19 pathogenesis pathogenesis NN cord-007796-zggk0x2q 200 20 . . . cord-007796-zggk0x2q 201 1 These these DT cord-007796-zggk0x2q 201 2 cells cell NNS cord-007796-zggk0x2q 201 3 were be VBD cord-007796-zggk0x2q 201 4 already already RB cord-007796-zggk0x2q 201 5 appreciated appreciate VBN cord-007796-zggk0x2q 201 6 for for IN cord-007796-zggk0x2q 201 7 their -PRON- PRP$ cord-007796-zggk0x2q 201 8 role role NN cord-007796-zggk0x2q 201 9 in in IN cord-007796-zggk0x2q 201 10 antigen antigen NN cord-007796-zggk0x2q 201 11 presentation presentation NN cord-007796-zggk0x2q 201 12 , , , cord-007796-zggk0x2q 201 13 at at IN cord-007796-zggk0x2q 201 14 which which WDT cord-007796-zggk0x2q 201 15 dendritic dendritic JJ cord-007796-zggk0x2q 201 16 cells cell NNS cord-007796-zggk0x2q 201 17 are be VBP cord-007796-zggk0x2q 201 18 by by IN cord-007796-zggk0x2q 201 19 far far RB cord-007796-zggk0x2q 201 20 superior superior JJ cord-007796-zggk0x2q 201 21 . . . cord-007796-zggk0x2q 202 1 Macrophages macrophage NNS cord-007796-zggk0x2q 202 2 express express VBP cord-007796-zggk0x2q 202 3 phagocyte phagocyte NN cord-007796-zggk0x2q 202 4 activity activity NN cord-007796-zggk0x2q 202 5 , , , cord-007796-zggk0x2q 202 6 which which WDT cord-007796-zggk0x2q 202 7 may may MD cord-007796-zggk0x2q 202 8 be be VB cord-007796-zggk0x2q 202 9 of of IN cord-007796-zggk0x2q 202 10 importance importance NN cord-007796-zggk0x2q 202 11 in in IN cord-007796-zggk0x2q 202 12 clearance clearance NN cord-007796-zggk0x2q 202 13 of of IN cord-007796-zggk0x2q 202 14 infected infected JJ cord-007796-zggk0x2q 202 15 epithelial epithelial JJ cord-007796-zggk0x2q 202 16 cellular cellular JJ cord-007796-zggk0x2q 202 17 debris debris NN cord-007796-zggk0x2q 202 18 . . . cord-007796-zggk0x2q 203 1 Fascinating fascinating JJ cord-007796-zggk0x2q 203 2 new new JJ cord-007796-zggk0x2q 203 3 players player NNS cord-007796-zggk0x2q 203 4 in in IN cord-007796-zggk0x2q 203 5 host host NN cord-007796-zggk0x2q 203 6 defense defense NN cord-007796-zggk0x2q 203 7 against against IN cord-007796-zggk0x2q 203 8 viruses virus NNS cord-007796-zggk0x2q 203 9 are be VBP cord-007796-zggk0x2q 203 10 pattern pattern NN cord-007796-zggk0x2q 203 11 recognition recognition NN cord-007796-zggk0x2q 203 12 receptors receptor NNS cord-007796-zggk0x2q 203 13 . . . cord-007796-zggk0x2q 204 1 Toll toll NN cord-007796-zggk0x2q 204 2 - - HYPH cord-007796-zggk0x2q 204 3 like like JJ cord-007796-zggk0x2q 204 4 receptor-4 receptor-4 NNP cord-007796-zggk0x2q 205 1 ( ( -LRB- cord-007796-zggk0x2q 205 2 TLR-4 TLR-4 NNP cord-007796-zggk0x2q 205 3 ) ) -RRB- cord-007796-zggk0x2q 205 4 and and CC cord-007796-zggk0x2q 205 5 CD14 CD14 NNP cord-007796-zggk0x2q 205 6 , , , cord-007796-zggk0x2q 205 7 both both DT cord-007796-zggk0x2q 205 8 present present JJ cord-007796-zggk0x2q 205 9 in in IN cord-007796-zggk0x2q 205 10 a a DT cord-007796-zggk0x2q 205 11 complex complex NN cord-007796-zggk0x2q 205 12 on on IN cord-007796-zggk0x2q 205 13 these these DT cord-007796-zggk0x2q 205 14 cells cell NNS cord-007796-zggk0x2q 205 15 , , , cord-007796-zggk0x2q 205 16 have have VBP cord-007796-zggk0x2q 205 17 been be VBN cord-007796-zggk0x2q 205 18 found find VBN cord-007796-zggk0x2q 205 19 to to TO cord-007796-zggk0x2q 205 20 interact interact VB cord-007796-zggk0x2q 205 21 with with IN cord-007796-zggk0x2q 205 22 RSV RSV NNP cord-007796-zggk0x2q 205 23 and and CC cord-007796-zggk0x2q 205 24 receptor receptor NN cord-007796-zggk0x2q 205 25 - - HYPH cord-007796-zggk0x2q 205 26 binding bind VBG cord-007796-zggk0x2q 205 27 results result NNS cord-007796-zggk0x2q 205 28 in in IN cord-007796-zggk0x2q 205 29 triggering trigger VBG cord-007796-zggk0x2q 205 30 of of IN cord-007796-zggk0x2q 205 31 the the DT cord-007796-zggk0x2q 205 32 innate innate JJ cord-007796-zggk0x2q 205 33 immune immune JJ cord-007796-zggk0x2q 205 34 system system NN cord-007796-zggk0x2q 205 35 . . . cord-007796-zggk0x2q 206 1 TLR-4 TLR-4 NNP cord-007796-zggk0x2q 206 2 has have VBZ cord-007796-zggk0x2q 206 3 been be VBN cord-007796-zggk0x2q 206 4 shown show VBN cord-007796-zggk0x2q 206 5 to to TO cord-007796-zggk0x2q 206 6 activate activate VB cord-007796-zggk0x2q 206 7 NF NF NNP cord-007796-zggk0x2q 206 8 - - HYPH cord-007796-zggk0x2q 206 9 kB kB NNP cord-007796-zggk0x2q 206 10 in in IN cord-007796-zggk0x2q 206 11 macrophages macrophage NNS cord-007796-zggk0x2q 206 12 of of IN cord-007796-zggk0x2q 206 13 RSV RSV NNP cord-007796-zggk0x2q 206 14 - - HYPH cord-007796-zggk0x2q 206 15 infected infect VBN cord-007796-zggk0x2q 206 16 mice mouse NNS cord-007796-zggk0x2q 207 1 ( ( -LRB- cord-007796-zggk0x2q 207 2 Haeberle Haeberle NNP cord-007796-zggk0x2q 207 3 et et NNP cord-007796-zggk0x2q 207 4 al al NNP cord-007796-zggk0x2q 207 5 . . NNP cord-007796-zggk0x2q 207 6 , , , cord-007796-zggk0x2q 207 7 2002a 2002a CD cord-007796-zggk0x2q 207 8 , , , cord-007796-zggk0x2q 207 9 b b LS cord-007796-zggk0x2q 207 10 ) ) -RRB- cord-007796-zggk0x2q 207 11 and and CC cord-007796-zggk0x2q 207 12 TLR-4-deficient tlr-4-deficient NN cord-007796-zggk0x2q 207 13 mice mouse NNS cord-007796-zggk0x2q 207 14 have have VBP cord-007796-zggk0x2q 207 15 impaired impair VBN cord-007796-zggk0x2q 207 16 NK nk NN cord-007796-zggk0x2q 207 17 - - HYPH cord-007796-zggk0x2q 207 18 cell cell NN cord-007796-zggk0x2q 207 19 and and CC cord-007796-zggk0x2q 207 20 CD14ϩ cd14ϩ JJ cord-007796-zggk0x2q 207 21 cell cell NN cord-007796-zggk0x2q 207 22 trafficking trafficking NN cord-007796-zggk0x2q 207 23 and and CC cord-007796-zggk0x2q 207 24 delayed delay VBN cord-007796-zggk0x2q 207 25 viral viral JJ cord-007796-zggk0x2q 207 26 clearance clearance NN cord-007796-zggk0x2q 207 27 . . . cord-007796-zggk0x2q 208 1 Furthermore furthermore RB cord-007796-zggk0x2q 208 2 , , , cord-007796-zggk0x2q 208 3 intracellular intracellular JJ cord-007796-zggk0x2q 208 4 pattern pattern NN cord-007796-zggk0x2q 208 5 recognition recognition NN cord-007796-zggk0x2q 208 6 receptors receptor NNS cord-007796-zggk0x2q 208 7 TLR-3 TLR-3 NNP cord-007796-zggk0x2q 208 8 and and CC cord-007796-zggk0x2q 208 9 -7 -7 NNP cord-007796-zggk0x2q 208 10 , , , cord-007796-zggk0x2q 208 11 may may MD cord-007796-zggk0x2q 208 12 be be VB cord-007796-zggk0x2q 208 13 involved involve VBN cord-007796-zggk0x2q 208 14 in in IN cord-007796-zggk0x2q 208 15 recognizing recognize VBG cord-007796-zggk0x2q 208 16 doubleand doubleand JJ cord-007796-zggk0x2q 208 17 single single RB cord-007796-zggk0x2q 208 18 - - HYPH cord-007796-zggk0x2q 208 19 stranded strand VBN cord-007796-zggk0x2q 208 20 RNA RNA NNP cord-007796-zggk0x2q 208 21 ( ( -LRB- cord-007796-zggk0x2q 208 22 dsRNA dsrna NN cord-007796-zggk0x2q 208 23 / / SYM cord-007796-zggk0x2q 208 24 ssRNA ssrna NN cord-007796-zggk0x2q 208 25 ) ) -RRB- cord-007796-zggk0x2q 208 26 , , , cord-007796-zggk0x2q 208 27 respectively respectively RB cord-007796-zggk0x2q 209 1 ( ( -LRB- cord-007796-zggk0x2q 209 2 Akira Akira NNP cord-007796-zggk0x2q 209 3 and and CC cord-007796-zggk0x2q 209 4 Hemmi Hemmi NNP cord-007796-zggk0x2q 209 5 , , , cord-007796-zggk0x2q 209 6 2003 2003 CD cord-007796-zggk0x2q 209 7 ; ; : cord-007796-zggk0x2q 209 8 Lund Lund NNP cord-007796-zggk0x2q 209 9 et et NNP cord-007796-zggk0x2q 209 10 al al NNP cord-007796-zggk0x2q 209 11 . . NNP cord-007796-zggk0x2q 209 12 , , , cord-007796-zggk0x2q 209 13 2004 2004 CD cord-007796-zggk0x2q 209 14 ) ) -RRB- cord-007796-zggk0x2q 209 15 . . . cord-007796-zggk0x2q 210 1 dsRNA dsRNA NNP cord-007796-zggk0x2q 210 2 is be VBZ cord-007796-zggk0x2q 210 3 produced produce VBN cord-007796-zggk0x2q 210 4 during during IN cord-007796-zggk0x2q 210 5 replication replication NN cord-007796-zggk0x2q 210 6 of of IN cord-007796-zggk0x2q 210 7 RNA RNA NNP cord-007796-zggk0x2q 210 8 - - HYPH cord-007796-zggk0x2q 210 9 viruses virus NNS cord-007796-zggk0x2q 210 10 and and CC cord-007796-zggk0x2q 210 11 is be VBZ cord-007796-zggk0x2q 210 12 a a DT cord-007796-zggk0x2q 210 13 potent potent JJ cord-007796-zggk0x2q 210 14 inducer inducer NN cord-007796-zggk0x2q 210 15 of of IN cord-007796-zggk0x2q 210 16 IFN- IFN- NNP cord-007796-zggk0x2q 210 17 ␣ ␣ NNP cord-007796-zggk0x2q 210 18 / / SYM cord-007796-zggk0x2q 210 19 ␤ ␤ NNP cord-007796-zggk0x2q 210 20 . . . cord-007796-zggk0x2q 211 1 All all DT cord-007796-zggk0x2q 211 2 human human JJ cord-007796-zggk0x2q 211 3 cells cell NNS cord-007796-zggk0x2q 211 4 can can MD cord-007796-zggk0x2q 211 5 produce produce VB cord-007796-zggk0x2q 211 6 IFN- IFN- NNP cord-007796-zggk0x2q 211 7 ␣ ␣ NNP cord-007796-zggk0x2q 211 8 / / SYM cord-007796-zggk0x2q 211 9 ␤ ␤ CC cord-007796-zggk0x2q 211 10 in in IN cord-007796-zggk0x2q 211 11 response response NN cord-007796-zggk0x2q 211 12 to to IN cord-007796-zggk0x2q 211 13 viral viral JJ cord-007796-zggk0x2q 211 14 infection infection NN cord-007796-zggk0x2q 211 15 , , , cord-007796-zggk0x2q 211 16 while while IN cord-007796-zggk0x2q 211 17 only only RB cord-007796-zggk0x2q 211 18 T t NN cord-007796-zggk0x2q 211 19 - - HYPH cord-007796-zggk0x2q 211 20 cells cell NNS cord-007796-zggk0x2q 211 21 and and CC cord-007796-zggk0x2q 211 22 NK nk NN cord-007796-zggk0x2q 211 23 - - HYPH cord-007796-zggk0x2q 211 24 cells cell NNS cord-007796-zggk0x2q 211 25 produce produce VBP cord-007796-zggk0x2q 211 26 IFN- IFN- NNP cord-007796-zggk0x2q 211 27 ␥ ␥ XX cord-007796-zggk0x2q 211 28 . . . cord-007796-zggk0x2q 211 29 dsRNA dsRNA NNP cord-007796-zggk0x2q 211 30 also also RB cord-007796-zggk0x2q 211 31 activates activate VBZ cord-007796-zggk0x2q 211 32 dsRNA dsrna JJ cord-007796-zggk0x2q 211 33 - - HYPH cord-007796-zggk0x2q 211 34 dependent dependent JJ cord-007796-zggk0x2q 211 35 protein protein NN cord-007796-zggk0x2q 211 36 kinase kinase NN cord-007796-zggk0x2q 211 37 R r NN cord-007796-zggk0x2q 211 38 ( ( -LRB- cord-007796-zggk0x2q 211 39 PKR PKR NNP cord-007796-zggk0x2q 211 40 ) ) -RRB- cord-007796-zggk0x2q 211 41 and and CC cord-007796-zggk0x2q 211 42 NF NF NNP cord-007796-zggk0x2q 211 43 - - HYPH cord-007796-zggk0x2q 211 44 kB kB NNP cord-007796-zggk0x2q 212 1 via via IN cord-007796-zggk0x2q 212 2 distinct distinct JJ cord-007796-zggk0x2q 212 3 pathways pathway NNS cord-007796-zggk0x2q 212 4 . . . cord-007796-zggk0x2q 213 1 Transcription transcription NN cord-007796-zggk0x2q 213 2 of of IN cord-007796-zggk0x2q 213 3 PKR PKR NNP cord-007796-zggk0x2q 213 4 is be VBZ cord-007796-zggk0x2q 213 5 under under IN cord-007796-zggk0x2q 213 6 control control NN cord-007796-zggk0x2q 213 7 of of IN cord-007796-zggk0x2q 213 8 IFN- IFN- NNP cord-007796-zggk0x2q 213 9 ␣ ␣ NNP cord-007796-zggk0x2q 213 10 / / SYM cord-007796-zggk0x2q 213 11 ␤ ␤ NNP cord-007796-zggk0x2q 213 12 . . . cord-007796-zggk0x2q 214 1 PKR PKR NNP cord-007796-zggk0x2q 214 2 controls control VBZ cord-007796-zggk0x2q 214 3 enzymes enzyme NNS cord-007796-zggk0x2q 214 4 directly directly RB cord-007796-zggk0x2q 214 5 involved involve VBN cord-007796-zggk0x2q 214 6 in in IN cord-007796-zggk0x2q 214 7 protein protein NN cord-007796-zggk0x2q 214 8 synthesis synthesis NN cord-007796-zggk0x2q 214 9 , , , cord-007796-zggk0x2q 214 10 thereby thereby RB cord-007796-zggk0x2q 214 11 inhibiting inhibit VBG cord-007796-zggk0x2q 214 12 cellular cellular JJ cord-007796-zggk0x2q 214 13 and and CC cord-007796-zggk0x2q 214 14 viral viral JJ cord-007796-zggk0x2q 214 15 protein protein NN cord-007796-zggk0x2q 214 16 translation translation NN cord-007796-zggk0x2q 214 17 . . . cord-007796-zggk0x2q 215 1 IFN- IFN- NNP cord-007796-zggk0x2q 216 1 ␣ ␣ NNP cord-007796-zggk0x2q 216 2 / / SYM cord-007796-zggk0x2q 216 3 ␤ ␤ IN cord-007796-zggk0x2q 216 4 -deficient -deficient CD cord-007796-zggk0x2q 216 5 mice mouse NNS cord-007796-zggk0x2q 216 6 as as RB cord-007796-zggk0x2q 216 7 well well RB cord-007796-zggk0x2q 216 8 as as IN cord-007796-zggk0x2q 217 1 PKRϪ/Ϫ pkrϫ/ϫ NN cord-007796-zggk0x2q 217 2 mice mouse NNS cord-007796-zggk0x2q 217 3 are be VBP cord-007796-zggk0x2q 217 4 extremely extremely RB cord-007796-zggk0x2q 217 5 sensitive sensitive JJ cord-007796-zggk0x2q 217 6 to to IN cord-007796-zggk0x2q 217 7 influenza influenza NN cord-007796-zggk0x2q 217 8 infection infection NN cord-007796-zggk0x2q 218 1 ( ( -LRB- cord-007796-zggk0x2q 218 2 Balachandran Balachandran NNP cord-007796-zggk0x2q 218 3 et et NNP cord-007796-zggk0x2q 218 4 al al NNP cord-007796-zggk0x2q 218 5 . . NNP cord-007796-zggk0x2q 218 6 , , , cord-007796-zggk0x2q 218 7 2000 2000 CD cord-007796-zggk0x2q 218 8 ) ) -RRB- cord-007796-zggk0x2q 218 9 . . . cord-007796-zggk0x2q 219 1 Several several JJ cord-007796-zggk0x2q 219 2 viruses virus NNS cord-007796-zggk0x2q 219 3 , , , cord-007796-zggk0x2q 219 4 including include VBG cord-007796-zggk0x2q 219 5 RSV RSV NNP cord-007796-zggk0x2q 219 6 , , , cord-007796-zggk0x2q 219 7 have have VBP cord-007796-zggk0x2q 219 8 evolved evolve VBN cord-007796-zggk0x2q 219 9 mechanisms mechanism NNS cord-007796-zggk0x2q 219 10 to to TO cord-007796-zggk0x2q 219 11 escape escape VB cord-007796-zggk0x2q 219 12 the the DT cord-007796-zggk0x2q 219 13 interferon interferon NN cord-007796-zggk0x2q 219 14 system system NN cord-007796-zggk0x2q 219 15 , , , cord-007796-zggk0x2q 219 16 which which WDT cord-007796-zggk0x2q 219 17 will will MD cord-007796-zggk0x2q 219 18 be be VB cord-007796-zggk0x2q 219 19 discussed discuss VBN cord-007796-zggk0x2q 219 20 below below RB cord-007796-zggk0x2q 219 21 . . . cord-007796-zggk0x2q 220 1 Respiratory respiratory JJ cord-007796-zggk0x2q 220 2 epithelial epithelial JJ cord-007796-zggk0x2q 220 3 cells cell NNS cord-007796-zggk0x2q 220 4 are be VBP cord-007796-zggk0x2q 220 5 the the DT cord-007796-zggk0x2q 220 6 principal principal JJ cord-007796-zggk0x2q 220 7 host host NN cord-007796-zggk0x2q 220 8 cells cell NNS cord-007796-zggk0x2q 220 9 for for IN cord-007796-zggk0x2q 220 10 viral viral JJ cord-007796-zggk0x2q 220 11 pathogens pathogen NNS cord-007796-zggk0x2q 220 12 in in IN cord-007796-zggk0x2q 220 13 lower low JJR cord-007796-zggk0x2q 220 14 respiratory respiratory JJ cord-007796-zggk0x2q 220 15 tract tract NN cord-007796-zggk0x2q 220 16 disease disease NN cord-007796-zggk0x2q 220 17 . . . cord-007796-zggk0x2q 221 1 The the DT cord-007796-zggk0x2q 221 2 degree degree NN cord-007796-zggk0x2q 221 3 of of IN cord-007796-zggk0x2q 221 4 replication replication NN cord-007796-zggk0x2q 221 5 and and CC cord-007796-zggk0x2q 221 6 the the DT cord-007796-zggk0x2q 221 7 mechanism mechanism NN cord-007796-zggk0x2q 221 8 of of IN cord-007796-zggk0x2q 221 9 spread spread NN cord-007796-zggk0x2q 221 10 along along IN cord-007796-zggk0x2q 221 11 the the DT cord-007796-zggk0x2q 221 12 epithelial epithelial JJ cord-007796-zggk0x2q 221 13 layer layer NN cord-007796-zggk0x2q 221 14 depend depend VB cord-007796-zggk0x2q 221 15 on on IN cord-007796-zggk0x2q 221 16 the the DT cord-007796-zggk0x2q 221 17 virus virus NN cord-007796-zggk0x2q 221 18 family family NN cord-007796-zggk0x2q 221 19 characteristics characteristic NNS cord-007796-zggk0x2q 221 20 . . . cord-007796-zggk0x2q 222 1 Through through IN cord-007796-zggk0x2q 222 2 the the DT cord-007796-zggk0x2q 222 3 fusion fusion NN cord-007796-zggk0x2q 222 4 ( ( -LRB- cord-007796-zggk0x2q 222 5 F F NNP cord-007796-zggk0x2q 222 6 ) ) -RRB- cord-007796-zggk0x2q 222 7 protein protein NN cord-007796-zggk0x2q 222 8 , , , cord-007796-zggk0x2q 222 9 RSV RSV NNP cord-007796-zggk0x2q 222 10 is be VBZ cord-007796-zggk0x2q 222 11 capable capable JJ cord-007796-zggk0x2q 222 12 of of IN cord-007796-zggk0x2q 222 13 syncytium syncytium NN cord-007796-zggk0x2q 222 14 formation formation NN cord-007796-zggk0x2q 222 15 , , , cord-007796-zggk0x2q 222 16 which which WDT cord-007796-zggk0x2q 222 17 allows allow VBZ cord-007796-zggk0x2q 222 18 it -PRON- PRP cord-007796-zggk0x2q 222 19 to to TO cord-007796-zggk0x2q 222 20 replicate replicate VB cord-007796-zggk0x2q 222 21 and and CC cord-007796-zggk0x2q 222 22 spread spread VB cord-007796-zggk0x2q 222 23 relatively relatively RB cord-007796-zggk0x2q 222 24 undetected undetected JJ cord-007796-zggk0x2q 222 25 by by IN cord-007796-zggk0x2q 222 26 the the DT cord-007796-zggk0x2q 222 27 immune immune JJ cord-007796-zggk0x2q 222 28 system system NN cord-007796-zggk0x2q 222 29 for for IN cord-007796-zggk0x2q 222 30 a a DT cord-007796-zggk0x2q 222 31 relatively relatively RB cord-007796-zggk0x2q 222 32 long long JJ cord-007796-zggk0x2q 222 33 period period NN cord-007796-zggk0x2q 222 34 . . . cord-007796-zggk0x2q 223 1 The the DT cord-007796-zggk0x2q 223 2 virus virus NN cord-007796-zggk0x2q 223 3 itself -PRON- PRP cord-007796-zggk0x2q 223 4 is be VBZ cord-007796-zggk0x2q 223 5 directly directly RB cord-007796-zggk0x2q 223 6 responsible responsible JJ cord-007796-zggk0x2q 223 7 for for IN cord-007796-zggk0x2q 223 8 cytopathology cytopathology NN cord-007796-zggk0x2q 223 9 and and CC cord-007796-zggk0x2q 223 10 viral viral JJ cord-007796-zggk0x2q 223 11 envelope envelope NN cord-007796-zggk0x2q 223 12 proteins protein NNS cord-007796-zggk0x2q 223 13 are be VBP cord-007796-zggk0x2q 223 14 expressed express VBN cord-007796-zggk0x2q 223 15 on on IN cord-007796-zggk0x2q 223 16 the the DT cord-007796-zggk0x2q 223 17 surface surface NN cord-007796-zggk0x2q 223 18 of of IN cord-007796-zggk0x2q 223 19 infected infected JJ cord-007796-zggk0x2q 223 20 epithelial epithelial JJ cord-007796-zggk0x2q 223 21 cells cell NNS cord-007796-zggk0x2q 223 22 . . . cord-007796-zggk0x2q 224 1 Dendritic dendritic JJ cord-007796-zggk0x2q 224 2 cells cell NNS cord-007796-zggk0x2q 224 3 , , , cord-007796-zggk0x2q 224 4 lining line VBG cord-007796-zggk0x2q 224 5 the the DT cord-007796-zggk0x2q 224 6 basal basal NN cord-007796-zggk0x2q 224 7 membrane membrane NN cord-007796-zggk0x2q 224 8 of of IN cord-007796-zggk0x2q 224 9 the the DT cord-007796-zggk0x2q 224 10 respiratory respiratory JJ cord-007796-zggk0x2q 224 11 epithelium epithelium NN cord-007796-zggk0x2q 224 12 encounter encounter NN cord-007796-zggk0x2q 224 13 RSV RSV NNP cord-007796-zggk0x2q 224 14 , , , cord-007796-zggk0x2q 224 15 pick pick VB cord-007796-zggk0x2q 224 16 up up RP cord-007796-zggk0x2q 224 17 viral viral JJ cord-007796-zggk0x2q 224 18 antigens antigen NNS cord-007796-zggk0x2q 224 19 and and CC cord-007796-zggk0x2q 224 20 migrate migrate VB cord-007796-zggk0x2q 224 21 to to IN cord-007796-zggk0x2q 224 22 mediastinal mediastinal JJ cord-007796-zggk0x2q 224 23 lymph lymph NN cord-007796-zggk0x2q 224 24 nodes node NNS cord-007796-zggk0x2q 224 25 where where WRB cord-007796-zggk0x2q 224 26 viral viral JJ cord-007796-zggk0x2q 224 27 antigen antigen NN cord-007796-zggk0x2q 224 28 is be VBZ cord-007796-zggk0x2q 224 29 presented present VBN cord-007796-zggk0x2q 224 30 to to IN cord-007796-zggk0x2q 224 31 naïve naïve JJ cord-007796-zggk0x2q 224 32 CD4ϩ CD4ϩ NNP cord-007796-zggk0x2q 224 33 T T NNP cord-007796-zggk0x2q 224 34 - - HYPH cord-007796-zggk0x2q 224 35 cells cell NNS cord-007796-zggk0x2q 224 36 . . . cord-007796-zggk0x2q 225 1 Antigen antigen NN cord-007796-zggk0x2q 225 2 presentation presentation NN cord-007796-zggk0x2q 225 3 and and CC cord-007796-zggk0x2q 225 4 co co JJ cord-007796-zggk0x2q 225 5 - - JJ cord-007796-zggk0x2q 225 6 stimulatory stimulatory JJ cord-007796-zggk0x2q 225 7 molecule molecule NN cord-007796-zggk0x2q 225 8 expression expression NN cord-007796-zggk0x2q 225 9 lead lead NN cord-007796-zggk0x2q 225 10 to to IN cord-007796-zggk0x2q 225 11 maturation maturation NN cord-007796-zggk0x2q 225 12 to to IN cord-007796-zggk0x2q 225 13 the the DT cord-007796-zggk0x2q 225 14 T t NN cord-007796-zggk0x2q 225 15 - - HYPH cord-007796-zggk0x2q 225 16 helper helper NN cord-007796-zggk0x2q 225 17 phenotype phenotype NN cord-007796-zggk0x2q 225 18 . . . cord-007796-zggk0x2q 226 1 This this DT cord-007796-zggk0x2q 226 2 then then RB cord-007796-zggk0x2q 226 3 induces induce VBZ cord-007796-zggk0x2q 226 4 B b NN cord-007796-zggk0x2q 226 5 - - HYPH cord-007796-zggk0x2q 226 6 cell cell NN cord-007796-zggk0x2q 226 7 proliferation proliferation NN cord-007796-zggk0x2q 226 8 with with IN cord-007796-zggk0x2q 226 9 the the DT cord-007796-zggk0x2q 226 10 production production NN cord-007796-zggk0x2q 226 11 of of IN cord-007796-zggk0x2q 226 12 specific specific JJ cord-007796-zggk0x2q 226 13 antibodies antibody NNS cord-007796-zggk0x2q 226 14 as as RB cord-007796-zggk0x2q 226 15 well well RB cord-007796-zggk0x2q 226 16 as as IN cord-007796-zggk0x2q 226 17 proliferation proliferation NN cord-007796-zggk0x2q 226 18 of of IN cord-007796-zggk0x2q 226 19 virus virus NN cord-007796-zggk0x2q 226 20 - - HYPH cord-007796-zggk0x2q 226 21 specific specific JJ cord-007796-zggk0x2q 226 22 cytotoxic cytotoxic JJ cord-007796-zggk0x2q 226 23 CD8-cells cd8-cell NNS cord-007796-zggk0x2q 226 24 . . . cord-007796-zggk0x2q 227 1 Cellular cellular JJ cord-007796-zggk0x2q 227 2 responses response NNS cord-007796-zggk0x2q 227 3 are be VBP cord-007796-zggk0x2q 227 4 responsible responsible JJ cord-007796-zggk0x2q 227 5 for for IN cord-007796-zggk0x2q 227 6 controlling control VBG cord-007796-zggk0x2q 227 7 and and CC cord-007796-zggk0x2q 227 8 terminating terminate VBG cord-007796-zggk0x2q 227 9 acute acute JJ cord-007796-zggk0x2q 227 10 infection infection NN cord-007796-zggk0x2q 227 11 with with IN cord-007796-zggk0x2q 227 12 RSV RSV NNP cord-007796-zggk0x2q 227 13 . . . cord-007796-zggk0x2q 228 1 In in IN cord-007796-zggk0x2q 228 2 primary primary JJ cord-007796-zggk0x2q 228 3 infections infection NNS cord-007796-zggk0x2q 228 4 , , , cord-007796-zggk0x2q 228 5 the the DT cord-007796-zggk0x2q 228 6 adaptive adaptive JJ cord-007796-zggk0x2q 228 7 cellular cellular JJ cord-007796-zggk0x2q 228 8 immune immune JJ cord-007796-zggk0x2q 228 9 response response NN cord-007796-zggk0x2q 228 10 develops develop VBZ cord-007796-zggk0x2q 228 11 within within IN cord-007796-zggk0x2q 228 12 10 10 CD cord-007796-zggk0x2q 228 13 days day NNS cord-007796-zggk0x2q 228 14 . . . cord-007796-zggk0x2q 229 1 These these DT cord-007796-zggk0x2q 229 2 CD8ϩ CD8ϩ NNP cord-007796-zggk0x2q 229 3 cells cell NNS cord-007796-zggk0x2q 229 4 can can MD cord-007796-zggk0x2q 229 5 recognize recognize VB cord-007796-zggk0x2q 229 6 and and CC cord-007796-zggk0x2q 229 7 eliminate eliminate VB cord-007796-zggk0x2q 229 8 virus virus NN cord-007796-zggk0x2q 229 9 - - HYPH cord-007796-zggk0x2q 229 10 infected infect VBN cord-007796-zggk0x2q 229 11 epithelial epithelial JJ cord-007796-zggk0x2q 229 12 cells cell NNS cord-007796-zggk0x2q 229 13 resulting result VBG cord-007796-zggk0x2q 229 14 in in IN cord-007796-zggk0x2q 229 15 perforin perforin NNP cord-007796-zggk0x2q 229 16 - - HYPH cord-007796-zggk0x2q 229 17 mediated mediate VBN cord-007796-zggk0x2q 229 18 cytotoxity cytotoxity NN cord-007796-zggk0x2q 229 19 . . . cord-007796-zggk0x2q 230 1 Epithelial epithelial JJ cord-007796-zggk0x2q 230 2 cells cell NNS cord-007796-zggk0x2q 230 3 are be VBP cord-007796-zggk0x2q 230 4 nonprofessional nonprofessional JJ cord-007796-zggk0x2q 230 5 antigen antigen NN cord-007796-zggk0x2q 230 6 presenting present VBG cord-007796-zggk0x2q 230 7 cells cell NNS cord-007796-zggk0x2q 230 8 ( ( -LRB- cord-007796-zggk0x2q 230 9 APC APC NNP cord-007796-zggk0x2q 230 10 ) ) -RRB- cord-007796-zggk0x2q 230 11 expressing express VBG cord-007796-zggk0x2q 230 12 MHC MHC NNP cord-007796-zggk0x2q 230 13 Class Class NNP cord-007796-zggk0x2q 230 14 l l NN cord-007796-zggk0x2q 230 15 on on IN cord-007796-zggk0x2q 230 16 the the DT cord-007796-zggk0x2q 230 17 surface surface NN cord-007796-zggk0x2q 230 18 ( ( -LRB- cord-007796-zggk0x2q 230 19 Garofalo Garofalo NNP cord-007796-zggk0x2q 230 20 et et NNP cord-007796-zggk0x2q 230 21 al al NNP cord-007796-zggk0x2q 230 22 . . NNP cord-007796-zggk0x2q 230 23 , , , cord-007796-zggk0x2q 230 24 1996 1996 CD cord-007796-zggk0x2q 230 25 ) ) -RRB- cord-007796-zggk0x2q 230 26 . . . cord-007796-zggk0x2q 231 1 When when WRB cord-007796-zggk0x2q 231 2 infected infect VBN cord-007796-zggk0x2q 231 3 , , , cord-007796-zggk0x2q 231 4 epithelial epithelial JJ cord-007796-zggk0x2q 231 5 cells cell NNS cord-007796-zggk0x2q 231 6 present present VBP cord-007796-zggk0x2q 231 7 viral viral JJ cord-007796-zggk0x2q 231 8 antigen antigen NN cord-007796-zggk0x2q 231 9 in in IN cord-007796-zggk0x2q 231 10 association association NN cord-007796-zggk0x2q 231 11 with with IN cord-007796-zggk0x2q 231 12 MHC MHC NNP cord-007796-zggk0x2q 231 13 Class Class NNP cord-007796-zggk0x2q 231 14 l l NNP cord-007796-zggk0x2q 231 15 molecules molecule NNS cord-007796-zggk0x2q 231 16 . . . cord-007796-zggk0x2q 232 1 MHC MHC NNP cord-007796-zggk0x2q 232 2 Class Class NNP cord-007796-zggk0x2q 232 3 l l NN cord-007796-zggk0x2q 232 4 restricted restrict VBD cord-007796-zggk0x2q 232 5 antigen antigen NN cord-007796-zggk0x2q 232 6 presentation presentation NN cord-007796-zggk0x2q 232 7 to to IN cord-007796-zggk0x2q 232 8 CD8ϩ CD8ϩ NNP cord-007796-zggk0x2q 232 9 cells cell NNS cord-007796-zggk0x2q 232 10 , , , cord-007796-zggk0x2q 232 11 among among IN cord-007796-zggk0x2q 232 12 other other JJ cord-007796-zggk0x2q 232 13 factors factor NNS cord-007796-zggk0x2q 232 14 , , , cord-007796-zggk0x2q 232 15 may may MD cord-007796-zggk0x2q 232 16 determine determine VB cord-007796-zggk0x2q 232 17 the the DT cord-007796-zggk0x2q 232 18 strength strength NN cord-007796-zggk0x2q 232 19 of of IN cord-007796-zggk0x2q 232 20 the the DT cord-007796-zggk0x2q 232 21 cytotoxic cytotoxic JJ cord-007796-zggk0x2q 232 22 response response NN cord-007796-zggk0x2q 232 23 . . . cord-007796-zggk0x2q 233 1 In in IN cord-007796-zggk0x2q 233 2 CD8-deficient cd8-deficient NN cord-007796-zggk0x2q 233 3 mice mouse NNS cord-007796-zggk0x2q 233 4 , , , cord-007796-zggk0x2q 233 5 there there EX cord-007796-zggk0x2q 233 6 is be VBZ cord-007796-zggk0x2q 233 7 delayed delay VBN cord-007796-zggk0x2q 233 8 viral viral JJ cord-007796-zggk0x2q 233 9 clearance clearance NN cord-007796-zggk0x2q 233 10 ; ; : cord-007796-zggk0x2q 233 11 however however RB cord-007796-zggk0x2q 233 12 , , , cord-007796-zggk0x2q 233 13 these these DT cord-007796-zggk0x2q 233 14 mice mouse NNS cord-007796-zggk0x2q 233 15 also also RB cord-007796-zggk0x2q 233 16 exhibit exhibit VBP cord-007796-zggk0x2q 233 17 decreased decrease VBD cord-007796-zggk0x2q 233 18 disease disease NN cord-007796-zggk0x2q 233 19 severity severity NN cord-007796-zggk0x2q 233 20 ( ( -LRB- cord-007796-zggk0x2q 233 21 Graham Graham NNP cord-007796-zggk0x2q 233 22 et et NNP cord-007796-zggk0x2q 233 23 al al NNP cord-007796-zggk0x2q 233 24 . . NNP cord-007796-zggk0x2q 233 25 , , , cord-007796-zggk0x2q 233 26 1991 1991 CD cord-007796-zggk0x2q 233 27 ) ) -RRB- cord-007796-zggk0x2q 233 28 . . . cord-007796-zggk0x2q 234 1 Therefore therefore RB cord-007796-zggk0x2q 234 2 , , , cord-007796-zggk0x2q 234 3 it -PRON- PRP cord-007796-zggk0x2q 234 4 is be VBZ cord-007796-zggk0x2q 234 5 conceivable conceivable JJ cord-007796-zggk0x2q 234 6 that that IN cord-007796-zggk0x2q 234 7 CD8ϩ CD8ϩ NNP cord-007796-zggk0x2q 234 8 T T NNP cord-007796-zggk0x2q 234 9 - - HYPH cord-007796-zggk0x2q 234 10 cells cell NNS cord-007796-zggk0x2q 234 11 are be VBP cord-007796-zggk0x2q 234 12 crucial crucial JJ cord-007796-zggk0x2q 234 13 in in IN cord-007796-zggk0x2q 234 14 viral viral JJ cord-007796-zggk0x2q 234 15 clearance clearance NN cord-007796-zggk0x2q 234 16 while while IN cord-007796-zggk0x2q 234 17 a a DT cord-007796-zggk0x2q 234 18 surplus surplus NN cord-007796-zggk0x2q 234 19 of of IN cord-007796-zggk0x2q 234 20 cytotoxicity cytotoxicity NN cord-007796-zggk0x2q 234 21 may may MD cord-007796-zggk0x2q 234 22 result result VB cord-007796-zggk0x2q 234 23 in in IN cord-007796-zggk0x2q 234 24 pulmonary pulmonary JJ cord-007796-zggk0x2q 234 25 injury injury NN cord-007796-zggk0x2q 234 26 . . . cord-007796-zggk0x2q 235 1 In in IN cord-007796-zggk0x2q 235 2 humans human NNS cord-007796-zggk0x2q 235 3 , , , cord-007796-zggk0x2q 235 4 a a DT cord-007796-zggk0x2q 235 5 cytotoxic cytotoxic JJ cord-007796-zggk0x2q 235 6 T t NN cord-007796-zggk0x2q 235 7 - - HYPH cord-007796-zggk0x2q 235 8 cell cell NN cord-007796-zggk0x2q 235 9 response response NN cord-007796-zggk0x2q 235 10 is be VBZ cord-007796-zggk0x2q 235 11 elicited elicit VBN cord-007796-zggk0x2q 235 12 against against IN cord-007796-zggk0x2q 235 13 all all DT cord-007796-zggk0x2q 235 14 viral viral JJ cord-007796-zggk0x2q 235 15 proteins protein NNS cord-007796-zggk0x2q 235 16 , , , cord-007796-zggk0x2q 235 17 except except IN cord-007796-zggk0x2q 235 18 the the DT cord-007796-zggk0x2q 235 19 G-(attachment)-protein G-(attachment)-protein NNP cord-007796-zggk0x2q 235 20 , , , cord-007796-zggk0x2q 235 21 which which WDT cord-007796-zggk0x2q 235 22 is be VBZ cord-007796-zggk0x2q 235 23 required require VBN cord-007796-zggk0x2q 235 24 for for IN cord-007796-zggk0x2q 235 25 cell cell NN cord-007796-zggk0x2q 235 26 entry entry NN cord-007796-zggk0x2q 235 27 ( ( -LRB- cord-007796-zggk0x2q 235 28 Bangham Bangham NNP cord-007796-zggk0x2q 235 29 et et NNP cord-007796-zggk0x2q 235 30 al al NNP cord-007796-zggk0x2q 235 31 . . NNP cord-007796-zggk0x2q 235 32 , , , cord-007796-zggk0x2q 235 33 1986 1986 CD cord-007796-zggk0x2q 235 34 ; ; : cord-007796-zggk0x2q 235 35 Hacking Hacking NNP cord-007796-zggk0x2q 235 36 and and CC cord-007796-zggk0x2q 235 37 Hull Hull NNP cord-007796-zggk0x2q 235 38 , , , cord-007796-zggk0x2q 235 39 2002 2002 CD cord-007796-zggk0x2q 235 40 ) ) -RRB- cord-007796-zggk0x2q 235 41 . . . cord-007796-zggk0x2q 236 1 It -PRON- PRP cord-007796-zggk0x2q 236 2 is be VBZ cord-007796-zggk0x2q 236 3 suggested suggest VBN cord-007796-zggk0x2q 236 4 that that IN cord-007796-zggk0x2q 236 5 a a DT cord-007796-zggk0x2q 236 6 defective defective JJ cord-007796-zggk0x2q 236 7 response response NN cord-007796-zggk0x2q 236 8 against against IN cord-007796-zggk0x2q 236 9 G g NN cord-007796-zggk0x2q 236 10 - - HYPH cord-007796-zggk0x2q 236 11 protein protein NN cord-007796-zggk0x2q 236 12 is be VBZ cord-007796-zggk0x2q 236 13 directly directly RB cord-007796-zggk0x2q 236 14 associated associate VBN cord-007796-zggk0x2q 236 15 with with IN cord-007796-zggk0x2q 236 16 enhanced enhanced JJ cord-007796-zggk0x2q 236 17 disease disease NN cord-007796-zggk0x2q 236 18 . . . cord-007796-zggk0x2q 237 1 However however RB cord-007796-zggk0x2q 237 2 , , , cord-007796-zggk0x2q 237 3 G g NN cord-007796-zggk0x2q 237 4 - - HYPH cord-007796-zggk0x2q 237 5 protein protein NN cord-007796-zggk0x2q 237 6 can can MD cord-007796-zggk0x2q 237 7 induce induce VB cord-007796-zggk0x2q 237 8 a a DT cord-007796-zggk0x2q 237 9 CD4ϩ CD4ϩ NNP cord-007796-zggk0x2q 237 10 response response NN cord-007796-zggk0x2q 237 11 in in IN cord-007796-zggk0x2q 237 12 mice mouse NNS cord-007796-zggk0x2q 237 13 , , , cord-007796-zggk0x2q 237 14 which which WDT cord-007796-zggk0x2q 237 15 is be VBZ cord-007796-zggk0x2q 237 16 associated associate VBN cord-007796-zggk0x2q 237 17 with with IN cord-007796-zggk0x2q 237 18 Th2-cytokine th2-cytokine JJ cord-007796-zggk0x2q 237 19 production production NN cord-007796-zggk0x2q 237 20 and and CC cord-007796-zggk0x2q 237 21 eosinophilia eosinophilia NN cord-007796-zggk0x2q 237 22 both both DT cord-007796-zggk0x2q 237 23 during during IN cord-007796-zggk0x2q 237 24 primary primary JJ cord-007796-zggk0x2q 237 25 and and CC cord-007796-zggk0x2q 237 26 secondary secondary JJ cord-007796-zggk0x2q 237 27 infection infection NN cord-007796-zggk0x2q 237 28 ( ( -LRB- cord-007796-zggk0x2q 237 29 Openshaw Openshaw NNP cord-007796-zggk0x2q 237 30 , , , cord-007796-zggk0x2q 237 31 1995 1995 CD cord-007796-zggk0x2q 237 32 ) ) -RRB- cord-007796-zggk0x2q 237 33 . . . cord-007796-zggk0x2q 238 1 The the DT cord-007796-zggk0x2q 238 2 immune immune JJ cord-007796-zggk0x2q 238 3 response response NN cord-007796-zggk0x2q 238 4 to to IN cord-007796-zggk0x2q 238 5 the the DT cord-007796-zggk0x2q 238 6 F F NNP cord-007796-zggk0x2q 238 7 - - HYPH cord-007796-zggk0x2q 238 8 protein protein NNP cord-007796-zggk0x2q 238 9 is be VBZ cord-007796-zggk0x2q 238 10 dominated dominate VBN cord-007796-zggk0x2q 238 11 by by IN cord-007796-zggk0x2q 238 12 IFN- IFN- NNP cord-007796-zggk0x2q 238 13 ␥ ␥ CD cord-007796-zggk0x2q 238 14 production production NN cord-007796-zggk0x2q 238 15 and and CC cord-007796-zggk0x2q 238 16 subsequent subsequent JJ cord-007796-zggk0x2q 238 17 polarization polarization NN cord-007796-zggk0x2q 238 18 toward toward IN cord-007796-zggk0x2q 238 19 a a DT cord-007796-zggk0x2q 238 20 Th1-type Th1-type NNP cord-007796-zggk0x2q 238 21 cellular cellular JJ cord-007796-zggk0x2q 238 22 response response NN cord-007796-zggk0x2q 238 23 , , , cord-007796-zggk0x2q 238 24 and and CC cord-007796-zggk0x2q 238 25 therefore therefore RB cord-007796-zggk0x2q 238 26 it -PRON- PRP cord-007796-zggk0x2q 238 27 has have VBZ cord-007796-zggk0x2q 238 28 been be VBN cord-007796-zggk0x2q 238 29 postulated postulate VBN cord-007796-zggk0x2q 238 30 that that IN cord-007796-zggk0x2q 238 31 responses response NNS cord-007796-zggk0x2q 238 32 to to IN cord-007796-zggk0x2q 238 33 the the DT cord-007796-zggk0x2q 238 34 other other JJ cord-007796-zggk0x2q 238 35 viral viral JJ cord-007796-zggk0x2q 238 36 proteins protein NNS cord-007796-zggk0x2q 238 37 can can MD cord-007796-zggk0x2q 238 38 modulate modulate VB cord-007796-zggk0x2q 238 39 the the DT cord-007796-zggk0x2q 238 40 strong strong JJ cord-007796-zggk0x2q 238 41 Th2response th2response NN cord-007796-zggk0x2q 238 42 to to IN cord-007796-zggk0x2q 238 43 G g NN cord-007796-zggk0x2q 238 44 - - HYPH cord-007796-zggk0x2q 238 45 protein protein NN cord-007796-zggk0x2q 238 46 ( ( -LRB- cord-007796-zggk0x2q 238 47 Graham Graham NNP cord-007796-zggk0x2q 238 48 et et NNP cord-007796-zggk0x2q 238 49 al al NNP cord-007796-zggk0x2q 238 50 . . NNP cord-007796-zggk0x2q 238 51 , , , cord-007796-zggk0x2q 238 52 2000 2000 CD cord-007796-zggk0x2q 238 53 ) ) -RRB- cord-007796-zggk0x2q 238 54 . . . cord-007796-zggk0x2q 239 1 A a DT cord-007796-zggk0x2q 239 2 stronger strong JJR cord-007796-zggk0x2q 239 3 Th1-response Th1-response NNP cord-007796-zggk0x2q 239 4 seems seem VBZ cord-007796-zggk0x2q 239 5 to to TO cord-007796-zggk0x2q 239 6 induce induce VB cord-007796-zggk0x2q 239 7 a a DT cord-007796-zggk0x2q 239 8 more more RBR cord-007796-zggk0x2q 239 9 rapid rapid JJ cord-007796-zggk0x2q 239 10 viral viral JJ cord-007796-zggk0x2q 239 11 clearance clearance NN cord-007796-zggk0x2q 239 12 and and CC cord-007796-zggk0x2q 239 13 milder mild JJR cord-007796-zggk0x2q 239 14 disease disease NN cord-007796-zggk0x2q 240 1 ( ( -LRB- cord-007796-zggk0x2q 240 2 Bont Bont NNP cord-007796-zggk0x2q 240 3 et et NNP cord-007796-zggk0x2q 240 4 al al NNP cord-007796-zggk0x2q 240 5 . . NNP cord-007796-zggk0x2q 240 6 , , , cord-007796-zggk0x2q 240 7 1999 1999 CD cord-007796-zggk0x2q 240 8 ; ; : cord-007796-zggk0x2q 241 1 Legg Legg NNP cord-007796-zggk0x2q 241 2 et et NNP cord-007796-zggk0x2q 241 3 al al NNP cord-007796-zggk0x2q 241 4 . . NNP cord-007796-zggk0x2q 241 5 , , , cord-007796-zggk0x2q 241 6 2003 2003 CD cord-007796-zggk0x2q 241 7 ) ) -RRB- cord-007796-zggk0x2q 241 8 . . . cord-007796-zggk0x2q 242 1 Besides besides IN cord-007796-zggk0x2q 242 2 activated activate VBN cord-007796-zggk0x2q 242 3 T t NN cord-007796-zggk0x2q 242 4 - - HYPH cord-007796-zggk0x2q 242 5 cells cell NNS cord-007796-zggk0x2q 242 6 , , , cord-007796-zggk0x2q 242 7 NKcells NKcells NNP cord-007796-zggk0x2q 242 8 also also RB cord-007796-zggk0x2q 242 9 produce produce VBP cord-007796-zggk0x2q 242 10 considerable considerable JJ cord-007796-zggk0x2q 242 11 amounts amount NNS cord-007796-zggk0x2q 242 12 of of IN cord-007796-zggk0x2q 242 13 IFN- IFN- NNP cord-007796-zggk0x2q 242 14 ␥ ␥ XX cord-007796-zggk0x2q 242 15 ( ( -LRB- cord-007796-zggk0x2q 242 16 Hussell Hussell NNP cord-007796-zggk0x2q 242 17 and and CC cord-007796-zggk0x2q 242 18 Openshaw Openshaw NNP cord-007796-zggk0x2q 242 19 , , , cord-007796-zggk0x2q 242 20 1998 1998 CD cord-007796-zggk0x2q 242 21 ) ) -RRB- cord-007796-zggk0x2q 242 22 . . . cord-007796-zggk0x2q 243 1 IFN- IFN- NNP cord-007796-zggk0x2q 243 2 ␥ ␥ NNP cord-007796-zggk0x2q 243 3 has have VBZ cord-007796-zggk0x2q 243 4 important important JJ cord-007796-zggk0x2q 243 5 antiviral antiviral JJ cord-007796-zggk0x2q 243 6 effects effect NNS cord-007796-zggk0x2q 243 7 and and CC cord-007796-zggk0x2q 243 8 provides provide VBZ cord-007796-zggk0x2q 243 9 a a DT cord-007796-zggk0x2q 243 10 link link NN cord-007796-zggk0x2q 243 11 between between IN cord-007796-zggk0x2q 243 12 adaptive adaptive JJ cord-007796-zggk0x2q 243 13 and and CC cord-007796-zggk0x2q 243 14 innate innate JJ cord-007796-zggk0x2q 243 15 immune immune JJ cord-007796-zggk0x2q 243 16 system system NN cord-007796-zggk0x2q 243 17 . . . cord-007796-zggk0x2q 244 1 It -PRON- PRP cord-007796-zggk0x2q 244 2 can can MD cord-007796-zggk0x2q 244 3 induce induce VB cord-007796-zggk0x2q 244 4 expression expression NN cord-007796-zggk0x2q 244 5 of of IN cord-007796-zggk0x2q 244 6 TNF tnf NN cord-007796-zggk0x2q 244 7 - - HYPH cord-007796-zggk0x2q 244 8 related relate VBN cord-007796-zggk0x2q 244 9 apoptosis apoptosis NN cord-007796-zggk0x2q 244 10 inducing induce VBG cord-007796-zggk0x2q 244 11 ligand ligand NN cord-007796-zggk0x2q 244 12 ( ( -LRB- cord-007796-zggk0x2q 244 13 TRAIL TRAIL NNP cord-007796-zggk0x2q 244 14 ) ) -RRB- cord-007796-zggk0x2q 244 15 on on IN cord-007796-zggk0x2q 244 16 immune immune JJ cord-007796-zggk0x2q 244 17 cells cell NNS cord-007796-zggk0x2q 244 18 , , , cord-007796-zggk0x2q 244 19 which which WDT cord-007796-zggk0x2q 244 20 has have VBZ cord-007796-zggk0x2q 244 21 the the DT cord-007796-zggk0x2q 244 22 potential potential NN cord-007796-zggk0x2q 244 23 to to TO cord-007796-zggk0x2q 244 24 trigger trigger VB cord-007796-zggk0x2q 244 25 apoptosis apoptosis NN cord-007796-zggk0x2q 244 26 of of IN cord-007796-zggk0x2q 244 27 virus virus NN cord-007796-zggk0x2q 244 28 - - HYPH cord-007796-zggk0x2q 244 29 infected infect VBN cord-007796-zggk0x2q 244 30 cells cell NNS cord-007796-zggk0x2q 245 1 ( ( -LRB- cord-007796-zggk0x2q 245 2 Sedger Sedger NNP cord-007796-zggk0x2q 245 3 et et NNP cord-007796-zggk0x2q 245 4 al al NNP cord-007796-zggk0x2q 245 5 . . NNP cord-007796-zggk0x2q 245 6 , , , cord-007796-zggk0x2q 245 7 1999 1999 CD cord-007796-zggk0x2q 245 8 ) ) -RRB- cord-007796-zggk0x2q 245 9 . . . cord-007796-zggk0x2q 246 1 In in IN cord-007796-zggk0x2q 246 2 vitro vitro FW cord-007796-zggk0x2q 246 3 findings finding NNS cord-007796-zggk0x2q 246 4 suggest suggest VBP cord-007796-zggk0x2q 246 5 that that IN cord-007796-zggk0x2q 246 6 RSV RSV NNP cord-007796-zggk0x2q 246 7 - - HYPH cord-007796-zggk0x2q 246 8 infected infect VBN cord-007796-zggk0x2q 246 9 cells cell NNS cord-007796-zggk0x2q 246 10 in in IN cord-007796-zggk0x2q 246 11 vivo vivo NN cord-007796-zggk0x2q 246 12 are be VBP cord-007796-zggk0x2q 246 13 susceptible susceptible JJ cord-007796-zggk0x2q 246 14 to to IN cord-007796-zggk0x2q 246 15 killing kill VBG cord-007796-zggk0x2q 246 16 by by IN cord-007796-zggk0x2q 246 17 immune immune JJ cord-007796-zggk0x2q 246 18 cells cell NNS cord-007796-zggk0x2q 246 19 through through IN cord-007796-zggk0x2q 246 20 the the DT cord-007796-zggk0x2q 246 21 TRAIL TRAIL NNP cord-007796-zggk0x2q 246 22 pathway pathway NN cord-007796-zggk0x2q 247 1 ( ( -LRB- cord-007796-zggk0x2q 247 2 Kotelkin Kotelkin NNP cord-007796-zggk0x2q 247 3 et et FW cord-007796-zggk0x2q 247 4 al al NNP cord-007796-zggk0x2q 247 5 . . NNP cord-007796-zggk0x2q 247 6 , , , cord-007796-zggk0x2q 247 7 2003 2003 CD cord-007796-zggk0x2q 247 8 ) ) -RRB- cord-007796-zggk0x2q 247 9 . . . cord-007796-zggk0x2q 248 1 NK NK NNP cord-007796-zggk0x2q 248 2 - - HYPH cord-007796-zggk0x2q 248 3 cells cell NNS cord-007796-zggk0x2q 248 4 are be VBP cord-007796-zggk0x2q 248 5 also also RB cord-007796-zggk0x2q 248 6 thought think VBN cord-007796-zggk0x2q 248 7 to to TO cord-007796-zggk0x2q 248 8 play play VB cord-007796-zggk0x2q 248 9 a a DT cord-007796-zggk0x2q 248 10 role role NN cord-007796-zggk0x2q 248 11 in in IN cord-007796-zggk0x2q 248 12 activating activate VBG cord-007796-zggk0x2q 248 13 CD8ϩ CD8ϩ NNP cord-007796-zggk0x2q 248 14 cells cell NNS cord-007796-zggk0x2q 248 15 , , , cord-007796-zggk0x2q 248 16 further further RB cord-007796-zggk0x2q 248 17 modulating modulate VBG cord-007796-zggk0x2q 248 18 the the DT cord-007796-zggk0x2q 248 19 degree degree NN cord-007796-zggk0x2q 248 20 of of IN cord-007796-zggk0x2q 248 21 cytotoxicity cytotoxicity NN cord-007796-zggk0x2q 248 22 ( ( -LRB- cord-007796-zggk0x2q 248 23 Hussell Hussell NNP cord-007796-zggk0x2q 248 24 and and CC cord-007796-zggk0x2q 248 25 Openshaw Openshaw NNP cord-007796-zggk0x2q 248 26 , , , cord-007796-zggk0x2q 248 27 1998 1998 CD cord-007796-zggk0x2q 248 28 ) ) -RRB- cord-007796-zggk0x2q 248 29 . . . cord-007796-zggk0x2q 249 1 In in IN cord-007796-zggk0x2q 249 2 summary summary NN cord-007796-zggk0x2q 249 3 , , , cord-007796-zggk0x2q 249 4 in in IN cord-007796-zggk0x2q 249 5 RSV RSV NNP cord-007796-zggk0x2q 249 6 lower low JJR cord-007796-zggk0x2q 249 7 respiratory respiratory JJ cord-007796-zggk0x2q 249 8 tract tract NN cord-007796-zggk0x2q 249 9 infections infection NNS cord-007796-zggk0x2q 249 10 , , , cord-007796-zggk0x2q 249 11 cytotoxic cytotoxic JJ cord-007796-zggk0x2q 249 12 CD8ϩ CD8ϩ NNP cord-007796-zggk0x2q 249 13 T T NNP cord-007796-zggk0x2q 249 14 - - HYPH cord-007796-zggk0x2q 249 15 cells cell NNS cord-007796-zggk0x2q 249 16 are be VBP cord-007796-zggk0x2q 249 17 involved involve VBN cord-007796-zggk0x2q 249 18 in in IN cord-007796-zggk0x2q 249 19 viral viral JJ cord-007796-zggk0x2q 249 20 clearance clearance NN cord-007796-zggk0x2q 249 21 while while IN cord-007796-zggk0x2q 249 22 the the DT cord-007796-zggk0x2q 249 23 humoral humoral JJ cord-007796-zggk0x2q 249 24 response response NN cord-007796-zggk0x2q 249 25 is be VBZ cord-007796-zggk0x2q 249 26 required require VBN cord-007796-zggk0x2q 249 27 for for IN cord-007796-zggk0x2q 249 28 the the DT cord-007796-zggk0x2q 249 29 protection protection NN cord-007796-zggk0x2q 249 30 against against IN cord-007796-zggk0x2q 249 31 reinfection reinfection NN cord-007796-zggk0x2q 249 32 . . . cord-007796-zggk0x2q 250 1 However however RB cord-007796-zggk0x2q 250 2 , , , cord-007796-zggk0x2q 250 3 as as IN cord-007796-zggk0x2q 250 4 has have VBZ cord-007796-zggk0x2q 250 5 been be VBN cord-007796-zggk0x2q 250 6 discussed discuss VBN cord-007796-zggk0x2q 250 7 before before RB cord-007796-zggk0x2q 250 8 , , , cord-007796-zggk0x2q 250 9 memory memory NN cord-007796-zggk0x2q 250 10 is be VBZ cord-007796-zggk0x2q 250 11 incomplete incomplete JJ cord-007796-zggk0x2q 250 12 and and CC cord-007796-zggk0x2q 250 13 repeated repeat VBN cord-007796-zggk0x2q 250 14 infections infection NNS cord-007796-zggk0x2q 250 15 with with IN cord-007796-zggk0x2q 250 16 RSV RSV NNP cord-007796-zggk0x2q 250 17 are be VBP cord-007796-zggk0x2q 250 18 common common JJ cord-007796-zggk0x2q 250 19 . . . cord-007796-zggk0x2q 251 1 Both both DT cord-007796-zggk0x2q 251 2 IgM IgM NNP cord-007796-zggk0x2q 251 3 and and CC cord-007796-zggk0x2q 251 4 IgG IgG NNP cord-007796-zggk0x2q 251 5 as as RB cord-007796-zggk0x2q 251 6 well well RB cord-007796-zggk0x2q 251 7 as as IN cord-007796-zggk0x2q 251 8 secretory secretory JJ cord-007796-zggk0x2q 251 9 IgA IgA NNP cord-007796-zggk0x2q 251 10 against against IN cord-007796-zggk0x2q 251 11 RSV RSV NNP cord-007796-zggk0x2q 251 12 are be VBP cord-007796-zggk0x2q 251 13 formed form VBN cord-007796-zggk0x2q 251 14 in in IN cord-007796-zggk0x2q 251 15 infants infant NNS cord-007796-zggk0x2q 251 16 , , , cord-007796-zggk0x2q 251 17 and and CC cord-007796-zggk0x2q 251 18 a a DT cord-007796-zggk0x2q 251 19 more more RBR cord-007796-zggk0x2q 251 20 vigorous vigorous JJ cord-007796-zggk0x2q 251 21 antibody antibody NN cord-007796-zggk0x2q 251 22 response response NN cord-007796-zggk0x2q 251 23 seems seem VBZ cord-007796-zggk0x2q 251 24 to to TO cord-007796-zggk0x2q 251 25 be be VB cord-007796-zggk0x2q 251 26 protective protective JJ cord-007796-zggk0x2q 251 27 against against IN cord-007796-zggk0x2q 251 28 RSV RSV NNP cord-007796-zggk0x2q 251 29 infections infection NNS cord-007796-zggk0x2q 252 1 ( ( -LRB- cord-007796-zggk0x2q 252 2 Meurman Meurman NNP cord-007796-zggk0x2q 252 3 et et NNP cord-007796-zggk0x2q 252 4 al al NNP cord-007796-zggk0x2q 252 5 . . NNP cord-007796-zggk0x2q 252 6 , , , cord-007796-zggk0x2q 252 7 1984 1984 CD cord-007796-zggk0x2q 252 8 ; ; . cord-007796-zggk0x2q 253 1 Welliver Welliver NNP cord-007796-zggk0x2q 253 2 et et NNP cord-007796-zggk0x2q 253 3 al al NNP cord-007796-zggk0x2q 253 4 . . NNP cord-007796-zggk0x2q 253 5 , , , cord-007796-zggk0x2q 253 6 1989 1989 CD cord-007796-zggk0x2q 253 7 ) ) -RRB- cord-007796-zggk0x2q 253 8 . . . cord-007796-zggk0x2q 254 1 RSV RSV NNP cord-007796-zggk0x2q 254 2 infections infection NNS cord-007796-zggk0x2q 254 3 are be VBP cord-007796-zggk0x2q 254 4 most most RBS cord-007796-zggk0x2q 254 5 severe severe JJ cord-007796-zggk0x2q 254 6 in in IN cord-007796-zggk0x2q 254 7 the the DT cord-007796-zggk0x2q 254 8 youngest young JJS cord-007796-zggk0x2q 254 9 age age NN cord-007796-zggk0x2q 254 10 group group NN cord-007796-zggk0x2q 254 11 , , , cord-007796-zggk0x2q 254 12 which which WDT cord-007796-zggk0x2q 254 13 is be VBZ cord-007796-zggk0x2q 254 14 the the DT cord-007796-zggk0x2q 254 15 least least JJS cord-007796-zggk0x2q 254 16 mature mature JJ cord-007796-zggk0x2q 254 17 in in IN cord-007796-zggk0x2q 254 18 terms term NNS cord-007796-zggk0x2q 254 19 of of IN cord-007796-zggk0x2q 254 20 immunity immunity NN cord-007796-zggk0x2q 254 21 to to IN cord-007796-zggk0x2q 254 22 infections infection NNS cord-007796-zggk0x2q 254 23 . . . cord-007796-zggk0x2q 255 1 Relative relative JJ cord-007796-zggk0x2q 255 2 deficiencies deficiency NNS cord-007796-zggk0x2q 255 3 in in IN cord-007796-zggk0x2q 255 4 both both DT cord-007796-zggk0x2q 255 5 innate innate JJ cord-007796-zggk0x2q 255 6 and and CC cord-007796-zggk0x2q 255 7 antigen antigen NN cord-007796-zggk0x2q 255 8 - - HYPH cord-007796-zggk0x2q 255 9 specific specific JJ cord-007796-zggk0x2q 255 10 immunity immunity NN cord-007796-zggk0x2q 255 11 in in IN cord-007796-zggk0x2q 255 12 infancy infancy NN cord-007796-zggk0x2q 255 13 have have VBP cord-007796-zggk0x2q 255 14 been be VBN cord-007796-zggk0x2q 255 15 characterized characterize VBN cord-007796-zggk0x2q 255 16 . . . cord-007796-zggk0x2q 256 1 These these DT cord-007796-zggk0x2q 256 2 include include VBP cord-007796-zggk0x2q 256 3 delayed delay VBN cord-007796-zggk0x2q 256 4 trafficking trafficking NN cord-007796-zggk0x2q 256 5 of of IN cord-007796-zggk0x2q 256 6 immune immune JJ cord-007796-zggk0x2q 256 7 cells cell NNS cord-007796-zggk0x2q 256 8 , , , cord-007796-zggk0x2q 256 9 less less RBR cord-007796-zggk0x2q 256 10 - - HYPH cord-007796-zggk0x2q 256 11 efficient efficient JJ cord-007796-zggk0x2q 256 12 antigen antigen NN cord-007796-zggk0x2q 256 13 presentation presentation NN cord-007796-zggk0x2q 256 14 by by IN cord-007796-zggk0x2q 256 15 dendritic dendritic JJ cord-007796-zggk0x2q 256 16 cells cell NNS cord-007796-zggk0x2q 256 17 , , , cord-007796-zggk0x2q 256 18 and and CC cord-007796-zggk0x2q 256 19 impaired impaired JJ cord-007796-zggk0x2q 256 20 production production NN cord-007796-zggk0x2q 256 21 of of IN cord-007796-zggk0x2q 256 22 IFN- IFN- NNP cord-007796-zggk0x2q 256 23 ␥ ␥ NNP cord-007796-zggk0x2q 256 24 by by IN cord-007796-zggk0x2q 256 25 T T NNP cord-007796-zggk0x2q 256 26 - - HYPH cord-007796-zggk0x2q 256 27 cells cell NNS cord-007796-zggk0x2q 256 28 in in IN cord-007796-zggk0x2q 256 29 response response NN cord-007796-zggk0x2q 256 30 to to IN cord-007796-zggk0x2q 256 31 antigen antigen NN cord-007796-zggk0x2q 256 32 presentation presentation NN cord-007796-zggk0x2q 256 33 ( ( -LRB- cord-007796-zggk0x2q 256 34 Bont Bont NNP cord-007796-zggk0x2q 256 35 and and CC cord-007796-zggk0x2q 256 36 Kimpen Kimpen NNP cord-007796-zggk0x2q 256 37 , , , cord-007796-zggk0x2q 256 38 2002 2002 CD cord-007796-zggk0x2q 256 39 ) ) -RRB- cord-007796-zggk0x2q 256 40 . . . cord-007796-zggk0x2q 257 1 The the DT cord-007796-zggk0x2q 257 2 fetus fetus NN cord-007796-zggk0x2q 257 3 derives derive VBZ cord-007796-zggk0x2q 257 4 maternal maternal JJ cord-007796-zggk0x2q 257 5 IgG igg NN cord-007796-zggk0x2q 257 6 - - HYPH cord-007796-zggk0x2q 257 7 antibodies antibody NNS cord-007796-zggk0x2q 257 8 via via IN cord-007796-zggk0x2q 257 9 the the DT cord-007796-zggk0x2q 257 10 placenta placenta NN cord-007796-zggk0x2q 257 11 fairly fairly RB cord-007796-zggk0x2q 257 12 late late RB cord-007796-zggk0x2q 257 13 in in IN cord-007796-zggk0x2q 257 14 gestation gestation NN cord-007796-zggk0x2q 257 15 . . . cord-007796-zggk0x2q 258 1 This this DT cord-007796-zggk0x2q 258 2 partly partly RB cord-007796-zggk0x2q 258 3 explains explain VBZ cord-007796-zggk0x2q 258 4 why why WRB cord-007796-zggk0x2q 258 5 prematurity prematurity NN cord-007796-zggk0x2q 258 6 is be VBZ cord-007796-zggk0x2q 258 7 an an DT cord-007796-zggk0x2q 258 8 important important JJ cord-007796-zggk0x2q 258 9 risk risk NN cord-007796-zggk0x2q 258 10 factor factor NN cord-007796-zggk0x2q 258 11 for for IN cord-007796-zggk0x2q 258 12 severe severe JJ cord-007796-zggk0x2q 258 13 disease disease NN cord-007796-zggk0x2q 258 14 caused cause VBN cord-007796-zggk0x2q 258 15 by by IN cord-007796-zggk0x2q 258 16 RSV RSV NNP cord-007796-zggk0x2q 258 17 , , , cord-007796-zggk0x2q 258 18 as as RB cord-007796-zggk0x2q 258 19 well well RB cord-007796-zggk0x2q 258 20 as as IN cord-007796-zggk0x2q 258 21 the the DT cord-007796-zggk0x2q 258 22 physiological physiological JJ cord-007796-zggk0x2q 258 23 characteristics characteristic NNS cord-007796-zggk0x2q 258 24 of of IN cord-007796-zggk0x2q 258 25 the the DT cord-007796-zggk0x2q 258 26 small small JJ cord-007796-zggk0x2q 258 27 airways airway NNS cord-007796-zggk0x2q 258 28 . . . cord-007796-zggk0x2q 259 1 Antibody antibody NN cord-007796-zggk0x2q 259 2 titers titer NNS cord-007796-zggk0x2q 259 3 produced produce VBN cord-007796-zggk0x2q 259 4 by by IN cord-007796-zggk0x2q 259 5 infants infant NNS cord-007796-zggk0x2q 259 6 are be VBP cord-007796-zggk0x2q 259 7 relatively relatively RB cord-007796-zggk0x2q 259 8 low low JJ cord-007796-zggk0x2q 259 9 compared compare VBN cord-007796-zggk0x2q 259 10 to to IN cord-007796-zggk0x2q 259 11 older old JJR cord-007796-zggk0x2q 259 12 children child NNS cord-007796-zggk0x2q 259 13 . . . cord-007796-zggk0x2q 260 1 Trials trial NNS cord-007796-zggk0x2q 260 2 with with IN cord-007796-zggk0x2q 260 3 humanized humanized JJ cord-007796-zggk0x2q 260 4 monoclonal monoclonal JJ cord-007796-zggk0x2q 260 5 antibodies antibody NNS cord-007796-zggk0x2q 260 6 against against IN cord-007796-zggk0x2q 260 7 RSV RSV NNP cord-007796-zggk0x2q 260 8 - - HYPH cord-007796-zggk0x2q 260 9 F F NNP cord-007796-zggk0x2q 260 10 - - HYPH cord-007796-zggk0x2q 260 11 protein protein NN cord-007796-zggk0x2q 260 12 have have VBP cord-007796-zggk0x2q 260 13 shown show VBN cord-007796-zggk0x2q 260 14 a a DT cord-007796-zggk0x2q 260 15 50 50 CD cord-007796-zggk0x2q 260 16 % % NN cord-007796-zggk0x2q 260 17 reduction reduction NN cord-007796-zggk0x2q 260 18 in in IN cord-007796-zggk0x2q 260 19 RSV RSV NNP cord-007796-zggk0x2q 260 20 lower low JJR cord-007796-zggk0x2q 260 21 respiratory respiratory JJ cord-007796-zggk0x2q 260 22 tract tract NN cord-007796-zggk0x2q 260 23 - - HYPH cord-007796-zggk0x2q 260 24 related relate VBN cord-007796-zggk0x2q 260 25 hospitalizations hospitalization NNS cord-007796-zggk0x2q 260 26 in in IN cord-007796-zggk0x2q 260 27 this this DT cord-007796-zggk0x2q 260 28 highrisk highrisk JJ cord-007796-zggk0x2q 260 29 group group NN cord-007796-zggk0x2q 260 30 for for IN cord-007796-zggk0x2q 260 31 severe severe JJ cord-007796-zggk0x2q 260 32 disease disease NN cord-007796-zggk0x2q 261 1 ( ( -LRB- cord-007796-zggk0x2q 261 2 Impact Impact NNP cord-007796-zggk0x2q 261 3 Study Study NNP cord-007796-zggk0x2q 261 4 Group Group NNP cord-007796-zggk0x2q 261 5 , , , cord-007796-zggk0x2q 261 6 1998 1998 CD cord-007796-zggk0x2q 261 7 ) ) -RRB- cord-007796-zggk0x2q 261 8 . . . cord-007796-zggk0x2q 262 1 The the DT cord-007796-zggk0x2q 262 2 cytokine cytokine NN cord-007796-zggk0x2q 262 3 milieu milieu NN cord-007796-zggk0x2q 262 4 at at IN cord-007796-zggk0x2q 262 5 the the DT cord-007796-zggk0x2q 262 6 time time NN cord-007796-zggk0x2q 262 7 of of IN cord-007796-zggk0x2q 262 8 infection infection NN cord-007796-zggk0x2q 262 9 is be VBZ cord-007796-zggk0x2q 262 10 another another DT cord-007796-zggk0x2q 262 11 factor factor NN cord-007796-zggk0x2q 262 12 possibly possibly RB cord-007796-zggk0x2q 262 13 contributing contribute VBG cord-007796-zggk0x2q 262 14 to to IN cord-007796-zggk0x2q 262 15 the the DT cord-007796-zggk0x2q 262 16 occurrence occurrence NN cord-007796-zggk0x2q 262 17 of of IN cord-007796-zggk0x2q 262 18 severe severe JJ cord-007796-zggk0x2q 262 19 RSV RSV NNP cord-007796-zggk0x2q 262 20 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 262 21 especially especially RB cord-007796-zggk0x2q 262 22 in in IN cord-007796-zggk0x2q 262 23 the the DT cord-007796-zggk0x2q 262 24 youngest young JJS cord-007796-zggk0x2q 262 25 age age NN cord-007796-zggk0x2q 262 26 group group NN cord-007796-zggk0x2q 262 27 . . . cord-007796-zggk0x2q 263 1 At at IN cord-007796-zggk0x2q 263 2 birth birth NN cord-007796-zggk0x2q 263 3 , , , cord-007796-zggk0x2q 263 4 there there EX cord-007796-zggk0x2q 263 5 is be VBZ cord-007796-zggk0x2q 263 6 skewing skew VBG cord-007796-zggk0x2q 263 7 toward toward IN cord-007796-zggk0x2q 263 8 a a DT cord-007796-zggk0x2q 263 9 Th2-phenotype Th2-phenotype NNP cord-007796-zggk0x2q 263 10 and and CC cord-007796-zggk0x2q 263 11 RSV RSV NNP cord-007796-zggk0x2q 263 12 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 263 13 was be VBD cord-007796-zggk0x2q 263 14 long long RB cord-007796-zggk0x2q 263 15 thought think VBN cord-007796-zggk0x2q 263 16 to to TO cord-007796-zggk0x2q 263 17 be be VB cord-007796-zggk0x2q 263 18 a a DT cord-007796-zggk0x2q 263 19 Th2-type Th2-type NNP cord-007796-zggk0x2q 263 20 disease disease NN cord-007796-zggk0x2q 263 21 . . . cord-007796-zggk0x2q 264 1 This this DT cord-007796-zggk0x2q 264 2 role role NN cord-007796-zggk0x2q 264 3 of of IN cord-007796-zggk0x2q 264 4 Th2-skewing th2-skewing NN cord-007796-zggk0x2q 264 5 is be VBZ cord-007796-zggk0x2q 264 6 an an DT cord-007796-zggk0x2q 264 7 attractive attractive JJ cord-007796-zggk0x2q 264 8 concept concept NN cord-007796-zggk0x2q 264 9 , , , cord-007796-zggk0x2q 264 10 because because IN cord-007796-zggk0x2q 264 11 it -PRON- PRP cord-007796-zggk0x2q 264 12 provides provide VBZ cord-007796-zggk0x2q 264 13 some some DT cord-007796-zggk0x2q 264 14 explanation explanation NN cord-007796-zggk0x2q 264 15 for for IN cord-007796-zggk0x2q 264 16 the the DT cord-007796-zggk0x2q 264 17 association association NN cord-007796-zggk0x2q 264 18 between between IN cord-007796-zggk0x2q 264 19 RSV RSV NNP cord-007796-zggk0x2q 264 20 bronchiolitis bronchiolitis NNP cord-007796-zggk0x2q 264 21 and and CC cord-007796-zggk0x2q 264 22 the the DT cord-007796-zggk0x2q 264 23 development development NN cord-007796-zggk0x2q 264 24 of of IN cord-007796-zggk0x2q 264 25 asthma asthma NN cord-007796-zggk0x2q 264 26 . . . cord-007796-zggk0x2q 265 1 Asthma asthma NN cord-007796-zggk0x2q 265 2 and and CC cord-007796-zggk0x2q 265 3 allergy allergy NN cord-007796-zggk0x2q 265 4 have have VBP cord-007796-zggk0x2q 265 5 long long RB cord-007796-zggk0x2q 265 6 been be VBN cord-007796-zggk0x2q 265 7 acknowledged acknowledge VBN cord-007796-zggk0x2q 265 8 to to IN cord-007796-zggk0x2q 265 9 beTh2-mediated beth2-mediate VBN cord-007796-zggk0x2q 265 10 conditions condition NNS cord-007796-zggk0x2q 265 11 . . . cord-007796-zggk0x2q 266 1 However however RB cord-007796-zggk0x2q 266 2 , , , cord-007796-zggk0x2q 266 3 convincing convince VBG cord-007796-zggk0x2q 266 4 evidence evidence NN cord-007796-zggk0x2q 266 5 that that IN cord-007796-zggk0x2q 266 6 primary primary JJ cord-007796-zggk0x2q 266 7 RSV RSV NNP cord-007796-zggk0x2q 266 8 infections infection NNS cord-007796-zggk0x2q 266 9 are be VBP cord-007796-zggk0x2q 266 10 mediated mediate VBN cord-007796-zggk0x2q 266 11 by by IN cord-007796-zggk0x2q 266 12 Th2 Th2 NNP cord-007796-zggk0x2q 266 13 cytokines cytokine NNS cord-007796-zggk0x2q 266 14 is be VBZ cord-007796-zggk0x2q 266 15 lacking lack VBG cord-007796-zggk0x2q 266 16 . . . cord-007796-zggk0x2q 267 1 Dendritic dendritic JJ cord-007796-zggk0x2q 267 2 cells cell NNS cord-007796-zggk0x2q 267 3 are be VBP cord-007796-zggk0x2q 267 4 thought think VBN cord-007796-zggk0x2q 267 5 to to TO cord-007796-zggk0x2q 267 6 have have VB cord-007796-zggk0x2q 267 7 an an DT cord-007796-zggk0x2q 267 8 important important JJ cord-007796-zggk0x2q 267 9 function function NN cord-007796-zggk0x2q 267 10 in in IN cord-007796-zggk0x2q 267 11 skewing skew VBG cord-007796-zggk0x2q 267 12 the the DT cord-007796-zggk0x2q 267 13 Th1 th1 CD cord-007796-zggk0x2q 267 14 / / SYM cord-007796-zggk0x2q 267 15 Th2-ratio Th2-ratio NNP cord-007796-zggk0x2q 267 16 . . . cord-007796-zggk0x2q 268 1 Viruses virus NNS cord-007796-zggk0x2q 268 2 may may MD cord-007796-zggk0x2q 268 3 be be VB cord-007796-zggk0x2q 268 4 important important JJ cord-007796-zggk0x2q 268 5 in in IN cord-007796-zggk0x2q 268 6 maturation maturation NN cord-007796-zggk0x2q 268 7 of of IN cord-007796-zggk0x2q 268 8 dendritic dendritic JJ cord-007796-zggk0x2q 268 9 cells cell NNS cord-007796-zggk0x2q 268 10 , , , cord-007796-zggk0x2q 268 11 which which WDT cord-007796-zggk0x2q 268 12 can can MD cord-007796-zggk0x2q 268 13 then then RB cord-007796-zggk0x2q 268 14 drive drive VB cord-007796-zggk0x2q 268 15 differentiation differentiation NN cord-007796-zggk0x2q 268 16 of of IN cord-007796-zggk0x2q 268 17 naive naive JJ cord-007796-zggk0x2q 268 18 T t NN cord-007796-zggk0x2q 268 19 - - HYPH cord-007796-zggk0x2q 268 20 cells cell NNS cord-007796-zggk0x2q 268 21 into into IN cord-007796-zggk0x2q 268 22 either either CC cord-007796-zggk0x2q 268 23 a a DT cord-007796-zggk0x2q 268 24 Th2-or th2-or NN cord-007796-zggk0x2q 268 25 a a DT cord-007796-zggk0x2q 268 26 Th1-phenotype Th1-phenotype NNP cord-007796-zggk0x2q 268 27 . . . cord-007796-zggk0x2q 269 1 The the DT cord-007796-zggk0x2q 269 2 role role NN cord-007796-zggk0x2q 269 3 of of IN cord-007796-zggk0x2q 269 4 regulatory regulatory JJ cord-007796-zggk0x2q 269 5 T t NN cord-007796-zggk0x2q 269 6 - - HYPH cord-007796-zggk0x2q 269 7 cells cell NNS cord-007796-zggk0x2q 269 8 that that WDT cord-007796-zggk0x2q 269 9 suppress suppress VBP cord-007796-zggk0x2q 269 10 both both DT cord-007796-zggk0x2q 269 11 Th1 th1 NN cord-007796-zggk0x2q 269 12 and and CC cord-007796-zggk0x2q 269 13 Th2 th2 CD cord-007796-zggk0x2q 269 14 differentiation differentiation NN cord-007796-zggk0x2q 269 15 has have VBZ cord-007796-zggk0x2q 269 16 not not RB cord-007796-zggk0x2q 269 17 been be VBN cord-007796-zggk0x2q 269 18 studied study VBN cord-007796-zggk0x2q 269 19 in in IN cord-007796-zggk0x2q 269 20 RSV RSV NNP cord-007796-zggk0x2q 269 21 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 269 22 so so RB cord-007796-zggk0x2q 269 23 far far RB cord-007796-zggk0x2q 269 24 . . . cord-007796-zggk0x2q 270 1 Gene gene NN cord-007796-zggk0x2q 270 2 polymorphism polymorphism NN cord-007796-zggk0x2q 270 3 studies study NNS cord-007796-zggk0x2q 270 4 have have VBP cord-007796-zggk0x2q 270 5 been be VBN cord-007796-zggk0x2q 270 6 undertaken undertake VBN cord-007796-zggk0x2q 270 7 to to TO cord-007796-zggk0x2q 270 8 identify identify VB cord-007796-zggk0x2q 270 9 a a DT cord-007796-zggk0x2q 270 10 genetic genetic JJ cord-007796-zggk0x2q 270 11 background background NN cord-007796-zggk0x2q 270 12 to to TO cord-007796-zggk0x2q 270 13 explain explain VB cord-007796-zggk0x2q 270 14 the the DT cord-007796-zggk0x2q 270 15 individual individual JJ cord-007796-zggk0x2q 270 16 susceptibility susceptibility NN cord-007796-zggk0x2q 270 17 to to IN cord-007796-zggk0x2q 270 18 RSV RSV NNP cord-007796-zggk0x2q 270 19 lower low JJR cord-007796-zggk0x2q 270 20 respiratory respiratory JJ cord-007796-zggk0x2q 270 21 tract tract NN cord-007796-zggk0x2q 270 22 infection infection NN cord-007796-zggk0x2q 270 23 . . . cord-007796-zggk0x2q 271 1 Several several JJ cord-007796-zggk0x2q 271 2 polymorphisms polymorphism NNS cord-007796-zggk0x2q 271 3 situated situate VBN cord-007796-zggk0x2q 271 4 in in IN cord-007796-zggk0x2q 271 5 genes gene NNS cord-007796-zggk0x2q 271 6 relevant relevant JJ cord-007796-zggk0x2q 271 7 for for IN cord-007796-zggk0x2q 271 8 the the DT cord-007796-zggk0x2q 271 9 adaptive adaptive JJ cord-007796-zggk0x2q 271 10 and and CC cord-007796-zggk0x2q 271 11 innate innate JJ cord-007796-zggk0x2q 271 12 immunity immunity NN cord-007796-zggk0x2q 271 13 have have VBP cord-007796-zggk0x2q 271 14 been be VBN cord-007796-zggk0x2q 271 15 found find VBN cord-007796-zggk0x2q 271 16 to to TO cord-007796-zggk0x2q 271 17 correlate correlate VB cord-007796-zggk0x2q 271 18 with with IN cord-007796-zggk0x2q 271 19 occurrence occurrence NN cord-007796-zggk0x2q 271 20 of of IN cord-007796-zggk0x2q 271 21 RSV RSV NNP cord-007796-zggk0x2q 271 22 infection infection NN cord-007796-zggk0x2q 271 23 . . . cord-007796-zggk0x2q 272 1 Polymorphisms polymorphism NNS cord-007796-zggk0x2q 272 2 of of IN cord-007796-zggk0x2q 272 3 interleukin-4 interleukin-4 NNP cord-007796-zggk0x2q 272 4 , , , cord-007796-zggk0x2q 272 5 IL-4R IL-4R NNP cord-007796-zggk0x2q 272 6 , , , cord-007796-zggk0x2q 272 7 and and CC cord-007796-zggk0x2q 272 8 its -PRON- PRP$ cord-007796-zggk0x2q 272 9 receptor receptor NN cord-007796-zggk0x2q 272 10 , , , cord-007796-zggk0x2q 272 11 have have VBP cord-007796-zggk0x2q 272 12 been be VBN cord-007796-zggk0x2q 272 13 associated associate VBN cord-007796-zggk0x2q 272 14 with with IN cord-007796-zggk0x2q 272 15 RSV RSV NNP cord-007796-zggk0x2q 272 16 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 272 17 , , , cord-007796-zggk0x2q 272 18 which which WDT cord-007796-zggk0x2q 272 19 is be VBZ cord-007796-zggk0x2q 272 20 consistent consistent JJ cord-007796-zggk0x2q 272 21 with with IN cord-007796-zggk0x2q 272 22 the the DT cord-007796-zggk0x2q 272 23 Th2-hypothesis th2-hypothesis NN cord-007796-zggk0x2q 273 1 ( ( -LRB- cord-007796-zggk0x2q 273 2 Choi Choi NNP cord-007796-zggk0x2q 273 3 et et FW cord-007796-zggk0x2q 273 4 al al NNP cord-007796-zggk0x2q 273 5 . . . cord-007796-zggk0x2q 274 1 , , , cord-007796-zggk0x2q 274 2 2002 2002 CD cord-007796-zggk0x2q 274 3 ; ; : cord-007796-zggk0x2q 274 4 Hoebee Hoebee NNP cord-007796-zggk0x2q 274 5 et et NNP cord-007796-zggk0x2q 274 6 al al NNP cord-007796-zggk0x2q 274 7 . . NNP cord-007796-zggk0x2q 274 8 , , , cord-007796-zggk0x2q 274 9 2003 2003 CD cord-007796-zggk0x2q 274 10 ) ) -RRB- cord-007796-zggk0x2q 274 11 . . . cord-007796-zggk0x2q 275 1 Very very RB cord-007796-zggk0x2q 275 2 recently recently RB cord-007796-zggk0x2q 275 3 , , , cord-007796-zggk0x2q 275 4 a a DT cord-007796-zggk0x2q 275 5 polymorphism polymorphism NN cord-007796-zggk0x2q 275 6 of of IN cord-007796-zggk0x2q 275 7 the the DT cord-007796-zggk0x2q 275 8 gene gene NN cord-007796-zggk0x2q 275 9 coding code VBG cord-007796-zggk0x2q 275 10 for for IN cord-007796-zggk0x2q 275 11 interleukin-10 interleukin-10 NNP cord-007796-zggk0x2q 275 12 ( ( -LRB- cord-007796-zggk0x2q 275 13 IL-10 IL-10 NNP cord-007796-zggk0x2q 275 14 ) ) -RRB- cord-007796-zggk0x2q 275 15 was be VBD cord-007796-zggk0x2q 275 16 found find VBN cord-007796-zggk0x2q 275 17 as as RB cord-007796-zggk0x2q 275 18 well well RB cord-007796-zggk0x2q 276 1 ( ( -LRB- cord-007796-zggk0x2q 276 2 Hoebee Hoebee NNP cord-007796-zggk0x2q 276 3 et et NNP cord-007796-zggk0x2q 276 4 al al NNP cord-007796-zggk0x2q 276 5 . . NNP cord-007796-zggk0x2q 276 6 , , , cord-007796-zggk0x2q 276 7 2004 2004 CD cord-007796-zggk0x2q 276 8 ) ) -RRB- cord-007796-zggk0x2q 276 9 . . . cord-007796-zggk0x2q 277 1 This this DT cord-007796-zggk0x2q 277 2 is be VBZ cord-007796-zggk0x2q 277 3 particularly particularly RB cord-007796-zggk0x2q 277 4 interesting interesting JJ cord-007796-zggk0x2q 277 5 since since IN cord-007796-zggk0x2q 277 6 IL-10 IL-10 NNP cord-007796-zggk0x2q 277 7 is be VBZ cord-007796-zggk0x2q 277 8 a a DT cord-007796-zggk0x2q 277 9 cytokine cytokine NN cord-007796-zggk0x2q 277 10 produced produce VBN cord-007796-zggk0x2q 277 11 by by IN cord-007796-zggk0x2q 277 12 T t NN cord-007796-zggk0x2q 277 13 - - HYPH cord-007796-zggk0x2q 277 14 regulatory regulatory JJ cord-007796-zggk0x2q 277 15 cells cell NNS cord-007796-zggk0x2q 277 16 and and CC cord-007796-zggk0x2q 277 17 monocytes monocyte NNS cord-007796-zggk0x2q 277 18 , , , cord-007796-zggk0x2q 277 19 thought think VBD cord-007796-zggk0x2q 277 20 to to TO cord-007796-zggk0x2q 277 21 be be VB cord-007796-zggk0x2q 277 22 primarily primarily RB cord-007796-zggk0x2q 277 23 involved involve VBN cord-007796-zggk0x2q 277 24 in in IN cord-007796-zggk0x2q 277 25 development development NN cord-007796-zggk0x2q 277 26 of of IN cord-007796-zggk0x2q 277 27 allergy allergy NN cord-007796-zggk0x2q 277 28 . . . cord-007796-zggk0x2q 278 1 Gene gene NN cord-007796-zggk0x2q 278 2 polymorphisms polymorphism NNS cord-007796-zggk0x2q 278 3 involved involve VBN cord-007796-zggk0x2q 278 4 in in IN cord-007796-zggk0x2q 278 5 innate innate JJ cord-007796-zggk0x2q 278 6 immunity immunity NN cord-007796-zggk0x2q 278 7 include include VBP cord-007796-zggk0x2q 278 8 surfactant surfactant NN cord-007796-zggk0x2q 278 9 proteins protein NNS cord-007796-zggk0x2q 278 10 SPA spa NN cord-007796-zggk0x2q 278 11 and and CC cord-007796-zggk0x2q 278 12 D D NNP cord-007796-zggk0x2q 278 13 ( ( -LRB- cord-007796-zggk0x2q 278 14 Lahti Lahti NNP cord-007796-zggk0x2q 278 15 et et NNP cord-007796-zggk0x2q 278 16 al al NNP cord-007796-zggk0x2q 278 17 . . NNP cord-007796-zggk0x2q 278 18 , , , cord-007796-zggk0x2q 278 19 2002 2002 CD cord-007796-zggk0x2q 278 20 ) ) -RRB- cord-007796-zggk0x2q 278 21 , , , cord-007796-zggk0x2q 278 22 the the DT cord-007796-zggk0x2q 278 23 chemokine chemokine NN cord-007796-zggk0x2q 278 24 IL-8 il-8 NN cord-007796-zggk0x2q 278 25 ( ( -LRB- cord-007796-zggk0x2q 278 26 Hull Hull NNP cord-007796-zggk0x2q 278 27 et et FW cord-007796-zggk0x2q 278 28 al al NNP cord-007796-zggk0x2q 278 29 . . NNP cord-007796-zggk0x2q 278 30 , , , cord-007796-zggk0x2q 278 31 2001 2001 CD cord-007796-zggk0x2q 278 32 ) ) -RRB- cord-007796-zggk0x2q 278 33 , , , cord-007796-zggk0x2q 278 34 TLR-4 TLR-4 NNP cord-007796-zggk0x2q 279 1 ( ( -LRB- cord-007796-zggk0x2q 279 2 Tal Tal NNP cord-007796-zggk0x2q 279 3 et et FW cord-007796-zggk0x2q 279 4 al al NNP cord-007796-zggk0x2q 279 5 . . NNP cord-007796-zggk0x2q 279 6 , , , cord-007796-zggk0x2q 279 7 2004 2004 CD cord-007796-zggk0x2q 279 8 ) ) -RRB- cord-007796-zggk0x2q 279 9 , , , cord-007796-zggk0x2q 279 10 and and CC cord-007796-zggk0x2q 279 11 the the DT cord-007796-zggk0x2q 279 12 chemokine chemokine NN cord-007796-zggk0x2q 279 13 receptor receptor NN cord-007796-zggk0x2q 279 14 for for IN cord-007796-zggk0x2q 279 15 RANTES RANTES NNPS cord-007796-zggk0x2q 279 16 and and CC cord-007796-zggk0x2q 279 17 MIP-1 MIP-1 NNP cord-007796-zggk0x2q 279 18 ␣ ␣ ADD cord-007796-zggk0x2q 279 19 , , , cord-007796-zggk0x2q 279 20 CCR5 CCR5 NNP cord-007796-zggk0x2q 279 21 ( ( -LRB- cord-007796-zggk0x2q 279 22 Hull Hull NNP cord-007796-zggk0x2q 279 23 et et FW cord-007796-zggk0x2q 279 24 al al NNP cord-007796-zggk0x2q 279 25 . . NNP cord-007796-zggk0x2q 279 26 , , , cord-007796-zggk0x2q 279 27 2003 2003 CD cord-007796-zggk0x2q 279 28 ) ) -RRB- cord-007796-zggk0x2q 279 29 . . . cord-007796-zggk0x2q 280 1 Immunocompromised immunocompromise VBN cord-007796-zggk0x2q 280 2 patients patient NNS cord-007796-zggk0x2q 280 3 have have VBP cord-007796-zggk0x2q 280 4 a a DT cord-007796-zggk0x2q 280 5 higher high JJR cord-007796-zggk0x2q 280 6 risk risk NN cord-007796-zggk0x2q 280 7 of of IN cord-007796-zggk0x2q 280 8 developing develop VBG cord-007796-zggk0x2q 280 9 severe severe JJ cord-007796-zggk0x2q 280 10 disease disease NN cord-007796-zggk0x2q 280 11 from from IN cord-007796-zggk0x2q 280 12 viral viral JJ cord-007796-zggk0x2q 280 13 respiratory respiratory JJ cord-007796-zggk0x2q 280 14 tract tract NN cord-007796-zggk0x2q 280 15 infections infection NNS cord-007796-zggk0x2q 280 16 . . . cord-007796-zggk0x2q 281 1 In in IN cord-007796-zggk0x2q 281 2 particular particular JJ cord-007796-zggk0x2q 281 3 , , , cord-007796-zggk0x2q 281 4 the the DT cord-007796-zggk0x2q 281 5 presence presence NN cord-007796-zggk0x2q 281 6 of of IN cord-007796-zggk0x2q 281 7 defects defect NNS cord-007796-zggk0x2q 281 8 in in IN cord-007796-zggk0x2q 281 9 cellular cellular JJ cord-007796-zggk0x2q 281 10 immunity immunity NN cord-007796-zggk0x2q 281 11 result result NN cord-007796-zggk0x2q 281 12 in in IN cord-007796-zggk0x2q 281 13 an an DT cord-007796-zggk0x2q 281 14 increased increase VBN cord-007796-zggk0x2q 281 15 duration duration NN cord-007796-zggk0x2q 281 16 of of IN cord-007796-zggk0x2q 281 17 viral viral JJ cord-007796-zggk0x2q 281 18 shedding shedding NN cord-007796-zggk0x2q 281 19 and and CC cord-007796-zggk0x2q 281 20 enhanced enhanced JJ cord-007796-zggk0x2q 281 21 risk risk NN cord-007796-zggk0x2q 281 22 of of IN cord-007796-zggk0x2q 281 23 developing develop VBG cord-007796-zggk0x2q 281 24 severe severe JJ cord-007796-zggk0x2q 281 25 disease disease NN cord-007796-zggk0x2q 281 26 . . . cord-007796-zggk0x2q 282 1 Most Most JJS cord-007796-zggk0x2q 282 2 cellular cellular JJ cord-007796-zggk0x2q 282 3 immunodeficiencies immunodeficiency NNS cord-007796-zggk0x2q 282 4 are be VBP cord-007796-zggk0x2q 282 5 iatrogenic iatrogenic JJ cord-007796-zggk0x2q 282 6 in in IN cord-007796-zggk0x2q 282 7 nature nature NN cord-007796-zggk0x2q 282 8 . . . cord-007796-zggk0x2q 283 1 An an DT cord-007796-zggk0x2q 283 2 important important JJ cord-007796-zggk0x2q 283 3 cause cause NN cord-007796-zggk0x2q 283 4 is be VBZ cord-007796-zggk0x2q 283 5 intensive intensive JJ cord-007796-zggk0x2q 283 6 immunosuppressive immunosuppressive JJ cord-007796-zggk0x2q 283 7 treatment treatment NN cord-007796-zggk0x2q 283 8 . . . cord-007796-zggk0x2q 284 1 The the DT cord-007796-zggk0x2q 284 2 number number NN cord-007796-zggk0x2q 284 3 of of IN cord-007796-zggk0x2q 284 4 pediatric pediatric JJ cord-007796-zggk0x2q 284 5 patients patient NNS cord-007796-zggk0x2q 284 6 undergoing undergo VBG cord-007796-zggk0x2q 284 7 organ organ NN cord-007796-zggk0x2q 284 8 or or CC cord-007796-zggk0x2q 284 9 stem stem NN cord-007796-zggk0x2q 284 10 - - HYPH cord-007796-zggk0x2q 284 11 cell cell NN cord-007796-zggk0x2q 284 12 transplantation transplantation NN cord-007796-zggk0x2q 284 13 is be VBZ cord-007796-zggk0x2q 284 14 increasing increase VBG cord-007796-zggk0x2q 284 15 and and CC cord-007796-zggk0x2q 284 16 high high JJ cord-007796-zggk0x2q 284 17 doses dose NNS cord-007796-zggk0x2q 284 18 of of IN cord-007796-zggk0x2q 284 19 chemotherapeutic chemotherapeutic JJ cord-007796-zggk0x2q 284 20 and and CC cord-007796-zggk0x2q 284 21 immunosuppressive immunosuppressive JJ cord-007796-zggk0x2q 284 22 agents agent NNS cord-007796-zggk0x2q 284 23 are be VBP cord-007796-zggk0x2q 284 24 often often RB cord-007796-zggk0x2q 284 25 used use VBN cord-007796-zggk0x2q 284 26 in in IN cord-007796-zggk0x2q 284 27 the the DT cord-007796-zggk0x2q 284 28 pre pre NN cord-007796-zggk0x2q 284 29 - - NN cord-007796-zggk0x2q 284 30 and and CC cord-007796-zggk0x2q 284 31 posttransplant posttransplant NN cord-007796-zggk0x2q 284 32 regimens regimen NNS cord-007796-zggk0x2q 284 33 . . . cord-007796-zggk0x2q 285 1 Immunosuppressive immunosuppressive JJ cord-007796-zggk0x2q 285 2 drugs drug NNS cord-007796-zggk0x2q 285 3 are be VBP cord-007796-zggk0x2q 285 4 used use VBN cord-007796-zggk0x2q 285 5 in in IN cord-007796-zggk0x2q 285 6 cancer cancer NN cord-007796-zggk0x2q 285 7 treatment treatment NN cord-007796-zggk0x2q 285 8 regimens regimen NNS cord-007796-zggk0x2q 285 9 and and CC cord-007796-zggk0x2q 285 10 for for IN cord-007796-zggk0x2q 285 11 a a DT cord-007796-zggk0x2q 285 12 number number NN cord-007796-zggk0x2q 285 13 of of IN cord-007796-zggk0x2q 285 14 inflammatory inflammatory JJ cord-007796-zggk0x2q 285 15 conditions condition NNS cord-007796-zggk0x2q 285 16 . . . cord-007796-zggk0x2q 286 1 Community community NN cord-007796-zggk0x2q 286 2 acquired acquire VBD cord-007796-zggk0x2q 286 3 respiratory respiratory JJ cord-007796-zggk0x2q 286 4 viruses virus NNS cord-007796-zggk0x2q 286 5 such such JJ cord-007796-zggk0x2q 286 6 as as IN cord-007796-zggk0x2q 286 7 RSV RSV NNP cord-007796-zggk0x2q 286 8 , , , cord-007796-zggk0x2q 286 9 rhinovirus rhinovirus NN cord-007796-zggk0x2q 286 10 , , , cord-007796-zggk0x2q 286 11 adenovirus adenovirus NN cord-007796-zggk0x2q 286 12 , , , cord-007796-zggk0x2q 286 13 influenza influenza NN cord-007796-zggk0x2q 286 14 A a NN cord-007796-zggk0x2q 286 15 , , , cord-007796-zggk0x2q 286 16 influenza influenza NN cord-007796-zggk0x2q 286 17 B b NN cord-007796-zggk0x2q 286 18 , , , cord-007796-zggk0x2q 286 19 and and CC cord-007796-zggk0x2q 286 20 the the DT cord-007796-zggk0x2q 286 21 parainfluenza parainfluenza NNP cord-007796-zggk0x2q 286 22 group group NNP cord-007796-zggk0x2q 286 23 are be VBP cord-007796-zggk0x2q 286 24 frequent frequent JJ cord-007796-zggk0x2q 286 25 causes cause NNS cord-007796-zggk0x2q 286 26 of of IN cord-007796-zggk0x2q 286 27 respiratory respiratory JJ cord-007796-zggk0x2q 286 28 disease disease NN cord-007796-zggk0x2q 286 29 in in IN cord-007796-zggk0x2q 286 30 these these DT cord-007796-zggk0x2q 286 31 patients patient NNS cord-007796-zggk0x2q 286 32 ( ( -LRB- cord-007796-zggk0x2q 286 33 Soldatou Soldatou NNP cord-007796-zggk0x2q 286 34 and and CC cord-007796-zggk0x2q 286 35 Davies Davies NNP cord-007796-zggk0x2q 286 36 , , , cord-007796-zggk0x2q 286 37 2003 2003 CD cord-007796-zggk0x2q 286 38 ) ) -RRB- cord-007796-zggk0x2q 286 39 . . . cord-007796-zggk0x2q 287 1 Adenovirus Adenovirus NNP cord-007796-zggk0x2q 287 2 infections infection NNS cord-007796-zggk0x2q 287 3 have have VBP cord-007796-zggk0x2q 287 4 a a DT cord-007796-zggk0x2q 287 5 particularly particularly RB cord-007796-zggk0x2q 287 6 high high JJ cord-007796-zggk0x2q 287 7 risk risk NN cord-007796-zggk0x2q 287 8 of of IN cord-007796-zggk0x2q 287 9 adverse adverse JJ cord-007796-zggk0x2q 287 10 outcome outcome NN cord-007796-zggk0x2q 287 11 , , , cord-007796-zggk0x2q 287 12 mortality mortality NN cord-007796-zggk0x2q 287 13 rates rate NNS cord-007796-zggk0x2q 287 14 are be VBP cord-007796-zggk0x2q 287 15 high high JJ cord-007796-zggk0x2q 287 16 , , , cord-007796-zggk0x2q 287 17 and and CC cord-007796-zggk0x2q 287 18 no no DT cord-007796-zggk0x2q 287 19 effective effective JJ cord-007796-zggk0x2q 287 20 treatment treatment NN cord-007796-zggk0x2q 287 21 exists exist VBZ cord-007796-zggk0x2q 287 22 . . . cord-007796-zggk0x2q 288 1 The the DT cord-007796-zggk0x2q 288 2 presence presence NN cord-007796-zggk0x2q 288 3 of of IN cord-007796-zggk0x2q 288 4 lower low JJR cord-007796-zggk0x2q 288 5 respiratory respiratory JJ cord-007796-zggk0x2q 288 6 tract tract NN cord-007796-zggk0x2q 288 7 infection infection NN cord-007796-zggk0x2q 288 8 and and CC cord-007796-zggk0x2q 288 9 infection infection NN cord-007796-zggk0x2q 288 10 in in IN cord-007796-zggk0x2q 288 11 the the DT cord-007796-zggk0x2q 288 12 pre pre JJ cord-007796-zggk0x2q 288 13 - - JJ cord-007796-zggk0x2q 288 14 engraftment engraftment JJ cord-007796-zggk0x2q 288 15 phase phase NN cord-007796-zggk0x2q 288 16 of of IN cord-007796-zggk0x2q 288 17 HSCT HSCT NNP cord-007796-zggk0x2q 288 18 is be VBZ cord-007796-zggk0x2q 288 19 believed believe VBN cord-007796-zggk0x2q 288 20 to to TO cord-007796-zggk0x2q 288 21 have have VB cord-007796-zggk0x2q 288 22 a a DT cord-007796-zggk0x2q 288 23 particularly particularly RB cord-007796-zggk0x2q 288 24 poor poor JJ cord-007796-zggk0x2q 288 25 prognosis prognosis NN cord-007796-zggk0x2q 288 26 ( ( -LRB- cord-007796-zggk0x2q 288 27 Khushalani Khushalani NNP cord-007796-zggk0x2q 288 28 et et NNP cord-007796-zggk0x2q 288 29 al al NNP cord-007796-zggk0x2q 288 30 . . NNP cord-007796-zggk0x2q 288 31 , , , cord-007796-zggk0x2q 288 32 2001 2001 CD cord-007796-zggk0x2q 288 33 ) ) -RRB- cord-007796-zggk0x2q 288 34 . . . cord-007796-zggk0x2q 289 1 The the DT cord-007796-zggk0x2q 289 2 risk risk NN cord-007796-zggk0x2q 289 3 of of IN cord-007796-zggk0x2q 289 4 severe severe JJ cord-007796-zggk0x2q 289 5 disease disease NN cord-007796-zggk0x2q 289 6 is be VBZ cord-007796-zggk0x2q 289 7 higher high JJR cord-007796-zggk0x2q 289 8 during during IN cord-007796-zggk0x2q 289 9 allogenic allogenic JJ cord-007796-zggk0x2q 289 10 HSCT HSCT NNP cord-007796-zggk0x2q 289 11 than than IN cord-007796-zggk0x2q 289 12 autologous autologous JJ cord-007796-zggk0x2q 289 13 HSCT HSCT NNP cord-007796-zggk0x2q 289 14 . . . cord-007796-zggk0x2q 290 1 Besides besides IN cord-007796-zggk0x2q 290 2 causing cause VBG cord-007796-zggk0x2q 290 3 increased increase VBN cord-007796-zggk0x2q 290 4 morbidity morbidity NN cord-007796-zggk0x2q 290 5 and and CC cord-007796-zggk0x2q 290 6 mortality mortality NN cord-007796-zggk0x2q 290 7 , , , cord-007796-zggk0x2q 290 8 respiratory respiratory JJ cord-007796-zggk0x2q 290 9 tract tract NN cord-007796-zggk0x2q 290 10 infections infection NNS cord-007796-zggk0x2q 290 11 are be VBP cord-007796-zggk0x2q 290 12 associated associate VBN cord-007796-zggk0x2q 290 13 with with IN cord-007796-zggk0x2q 290 14 a a DT cord-007796-zggk0x2q 290 15 greater great JJR cord-007796-zggk0x2q 290 16 risk risk NN cord-007796-zggk0x2q 290 17 of of IN cord-007796-zggk0x2q 290 18 delayed delay VBN cord-007796-zggk0x2q 290 19 engraftment engraftment NN cord-007796-zggk0x2q 290 20 ( ( -LRB- cord-007796-zggk0x2q 290 21 Abdallah Abdallah NNP cord-007796-zggk0x2q 290 22 et et NNP cord-007796-zggk0x2q 290 23 al al NNP cord-007796-zggk0x2q 290 24 . . NNP cord-007796-zggk0x2q 290 25 , , , cord-007796-zggk0x2q 290 26 2003 2003 CD cord-007796-zggk0x2q 290 27 ) ) -RRB- cord-007796-zggk0x2q 290 28 . . . cord-007796-zggk0x2q 291 1 In in IN cord-007796-zggk0x2q 291 2 solid solid JJ cord-007796-zggk0x2q 291 3 organ organ NN cord-007796-zggk0x2q 291 4 transplant transplant NN cord-007796-zggk0x2q 291 5 patients patient NNS cord-007796-zggk0x2q 291 6 , , , cord-007796-zggk0x2q 291 7 respiratory respiratory JJ cord-007796-zggk0x2q 291 8 virus virus NN cord-007796-zggk0x2q 291 9 infections infection NNS cord-007796-zggk0x2q 291 10 are be VBP cord-007796-zggk0x2q 291 11 also also RB cord-007796-zggk0x2q 291 12 associated associate VBN cord-007796-zggk0x2q 291 13 with with IN cord-007796-zggk0x2q 291 14 a a DT cord-007796-zggk0x2q 291 15 higher high JJR cord-007796-zggk0x2q 291 16 incidence incidence NN cord-007796-zggk0x2q 291 17 of of IN cord-007796-zggk0x2q 291 18 rejection rejection NN cord-007796-zggk0x2q 291 19 ( ( -LRB- cord-007796-zggk0x2q 291 20 Wendt Wendt NNP cord-007796-zggk0x2q 291 21 , , , cord-007796-zggk0x2q 291 22 1997 1997 CD cord-007796-zggk0x2q 291 23 ) ) -RRB- cord-007796-zggk0x2q 291 24 . . . cord-007796-zggk0x2q 292 1 Prolonged prolonged JJ cord-007796-zggk0x2q 292 2 shedding shedding NN cord-007796-zggk0x2q 292 3 of of IN cord-007796-zggk0x2q 292 4 respiratory respiratory JJ cord-007796-zggk0x2q 292 5 viruses virus NNS cord-007796-zggk0x2q 292 6 for for IN cord-007796-zggk0x2q 292 7 weeks week NNS cord-007796-zggk0x2q 292 8 or or CC cord-007796-zggk0x2q 292 9 months month NNS cord-007796-zggk0x2q 292 10 has have VBZ cord-007796-zggk0x2q 292 11 been be VBN cord-007796-zggk0x2q 292 12 documented document VBN cord-007796-zggk0x2q 292 13 in in IN cord-007796-zggk0x2q 292 14 HIV HIV NNP cord-007796-zggk0x2q 292 15 - - HYPH cord-007796-zggk0x2q 292 16 infected infect VBN cord-007796-zggk0x2q 292 17 adults adult NNS cord-007796-zggk0x2q 292 18 and and CC cord-007796-zggk0x2q 292 19 children child NNS cord-007796-zggk0x2q 292 20 . . . cord-007796-zggk0x2q 293 1 This this DT cord-007796-zggk0x2q 293 2 has have VBZ cord-007796-zggk0x2q 293 3 important important JJ cord-007796-zggk0x2q 293 4 implications implication NNS cord-007796-zggk0x2q 293 5 for for IN cord-007796-zggk0x2q 293 6 infection infection NN cord-007796-zggk0x2q 293 7 control control NN cord-007796-zggk0x2q 293 8 in in IN cord-007796-zggk0x2q 293 9 medical medical JJ cord-007796-zggk0x2q 293 10 facilities facility NNS cord-007796-zggk0x2q 293 11 . . . cord-007796-zggk0x2q 294 1 In in IN cord-007796-zggk0x2q 294 2 addition addition NN cord-007796-zggk0x2q 294 3 , , , cord-007796-zggk0x2q 294 4 respiratory respiratory JJ cord-007796-zggk0x2q 294 5 viral viral JJ cord-007796-zggk0x2q 294 6 infection infection NN cord-007796-zggk0x2q 294 7 may may MD cord-007796-zggk0x2q 294 8 result result VB cord-007796-zggk0x2q 294 9 in in IN cord-007796-zggk0x2q 294 10 increased increase VBN cord-007796-zggk0x2q 294 11 HIV HIV NNP cord-007796-zggk0x2q 294 12 replication replication NN cord-007796-zggk0x2q 294 13 and and CC cord-007796-zggk0x2q 294 14 , , , cord-007796-zggk0x2q 294 15 theoretically theoretically RB cord-007796-zggk0x2q 294 16 , , , cord-007796-zggk0x2q 294 17 HIV HIV NNP cord-007796-zggk0x2q 294 18 disease disease NN cord-007796-zggk0x2q 294 19 progression progression NN cord-007796-zggk0x2q 294 20 ( ( -LRB- cord-007796-zggk0x2q 294 21 King King NNP cord-007796-zggk0x2q 294 22 , , , cord-007796-zggk0x2q 294 23 1997 1997 CD cord-007796-zggk0x2q 294 24 ) ) -RRB- cord-007796-zggk0x2q 294 25 . . . cord-007796-zggk0x2q 295 1 In in IN cord-007796-zggk0x2q 295 2 HIV HIV NNP cord-007796-zggk0x2q 295 3 - - HYPH cord-007796-zggk0x2q 295 4 infected infect VBN cord-007796-zggk0x2q 295 5 children child NNS cord-007796-zggk0x2q 295 6 , , , cord-007796-zggk0x2q 295 7 RSV RSV NNP cord-007796-zggk0x2q 295 8 infections infection NNS cord-007796-zggk0x2q 295 9 are be VBP cord-007796-zggk0x2q 295 10 less less RBR cord-007796-zggk0x2q 295 11 limited limit VBN cord-007796-zggk0x2q 295 12 by by IN cord-007796-zggk0x2q 295 13 season season NN cord-007796-zggk0x2q 296 1 ( ( -LRB- cord-007796-zggk0x2q 296 2 Madhi Madhi NNP cord-007796-zggk0x2q 296 3 et et FW cord-007796-zggk0x2q 296 4 al al NNP cord-007796-zggk0x2q 296 5 . . NNP cord-007796-zggk0x2q 296 6 , , , cord-007796-zggk0x2q 296 7 2000 2000 CD cord-007796-zggk0x2q 296 8 ) ) -RRB- cord-007796-zggk0x2q 296 9 . . . cord-007796-zggk0x2q 297 1 However however RB cord-007796-zggk0x2q 297 2 , , , cord-007796-zggk0x2q 297 3 generally generally RB cord-007796-zggk0x2q 297 4 , , , cord-007796-zggk0x2q 297 5 the the DT cord-007796-zggk0x2q 297 6 course course NN cord-007796-zggk0x2q 297 7 of of IN cord-007796-zggk0x2q 297 8 RSV RSV NNP cord-007796-zggk0x2q 297 9 infections infection NNS cord-007796-zggk0x2q 297 10 in in IN cord-007796-zggk0x2q 297 11 HIV HIV NNP cord-007796-zggk0x2q 297 12 patients patient NNS cord-007796-zggk0x2q 297 13 is be VBZ cord-007796-zggk0x2q 297 14 not not RB cord-007796-zggk0x2q 297 15 more more RBR cord-007796-zggk0x2q 297 16 severe severe JJ cord-007796-zggk0x2q 297 17 , , , cord-007796-zggk0x2q 297 18 unless unless IN cord-007796-zggk0x2q 297 19 there there EX cord-007796-zggk0x2q 297 20 is be VBZ cord-007796-zggk0x2q 297 21 profound profound JJ cord-007796-zggk0x2q 297 22 lymphopenia lymphopenia JJ cord-007796-zggk0x2q 297 23 or or CC cord-007796-zggk0x2q 297 24 pre pre JJ cord-007796-zggk0x2q 297 25 - - JJ cord-007796-zggk0x2q 297 26 existing existing JJ cord-007796-zggk0x2q 297 27 lung lung NN cord-007796-zggk0x2q 297 28 disease disease NN cord-007796-zggk0x2q 297 29 ( ( -LRB- cord-007796-zggk0x2q 297 30 Soldatou Soldatou NNP cord-007796-zggk0x2q 297 31 and and CC cord-007796-zggk0x2q 297 32 Davies Davies NNP cord-007796-zggk0x2q 297 33 , , , cord-007796-zggk0x2q 297 34 2003 2003 CD cord-007796-zggk0x2q 297 35 ) ) -RRB- cord-007796-zggk0x2q 297 36 . . . cord-007796-zggk0x2q 298 1 Other other JJ cord-007796-zggk0x2q 298 2 viruses virus NNS cord-007796-zggk0x2q 298 3 may may MD cord-007796-zggk0x2q 298 4 also also RB cord-007796-zggk0x2q 298 5 cause cause VB cord-007796-zggk0x2q 298 6 respiratory respiratory JJ cord-007796-zggk0x2q 298 7 complications complication NNS cord-007796-zggk0x2q 298 8 in in IN cord-007796-zggk0x2q 298 9 the the DT cord-007796-zggk0x2q 298 10 immunocompromised immunocompromised JJ cord-007796-zggk0x2q 298 11 patients patient NNS cord-007796-zggk0x2q 298 12 . . . cord-007796-zggk0x2q 299 1 In in IN cord-007796-zggk0x2q 299 2 particular particular JJ cord-007796-zggk0x2q 299 3 herpesviruses herpesviruse NNS cord-007796-zggk0x2q 299 4 , , , cord-007796-zggk0x2q 299 5 such such JJ cord-007796-zggk0x2q 299 6 as as IN cord-007796-zggk0x2q 299 7 cytomegalovirus cytomegalovirus NNP cord-007796-zggk0x2q 299 8 ( ( -LRB- cord-007796-zggk0x2q 299 9 CMV CMV NNP cord-007796-zggk0x2q 299 10 ) ) -RRB- cord-007796-zggk0x2q 299 11 and and CC cord-007796-zggk0x2q 299 12 varicella varicella NN cord-007796-zggk0x2q 299 13 zoster zoster NNP cord-007796-zggk0x2q 299 14 virus virus NN cord-007796-zggk0x2q 299 15 , , , cord-007796-zggk0x2q 299 16 can can MD cord-007796-zggk0x2q 299 17 cause cause VB cord-007796-zggk0x2q 299 18 severe severe JJ cord-007796-zggk0x2q 299 19 pneumonia pneumonia NN cord-007796-zggk0x2q 299 20 . . . cord-007796-zggk0x2q 300 1 With with IN cord-007796-zggk0x2q 300 2 a a DT cord-007796-zggk0x2q 300 3 CMV CMV NNP cord-007796-zggk0x2q 300 4 - - HYPH cord-007796-zggk0x2q 300 5 negative negative JJ cord-007796-zggk0x2q 300 6 donor donor NN cord-007796-zggk0x2q 300 7 and and CC cord-007796-zggk0x2q 300 8 a a DT cord-007796-zggk0x2q 300 9 CMV CMV NNP cord-007796-zggk0x2q 300 10 - - HYPH cord-007796-zggk0x2q 300 11 positive positive JJ cord-007796-zggk0x2q 300 12 recipient recipient NN cord-007796-zggk0x2q 300 13 , , , cord-007796-zggk0x2q 300 14 there there EX cord-007796-zggk0x2q 300 15 is be VBZ cord-007796-zggk0x2q 300 16 an an DT cord-007796-zggk0x2q 300 17 especially especially RB cord-007796-zggk0x2q 300 18 high high JJ cord-007796-zggk0x2q 300 19 risk risk NN cord-007796-zggk0x2q 300 20 of of IN cord-007796-zggk0x2q 300 21 reactivation reactivation NN cord-007796-zggk0x2q 300 22 which which WDT cord-007796-zggk0x2q 300 23 may may MD cord-007796-zggk0x2q 300 24 lead lead VB cord-007796-zggk0x2q 300 25 to to IN cord-007796-zggk0x2q 300 26 severe severe JJ cord-007796-zggk0x2q 300 27 disease disease NN cord-007796-zggk0x2q 300 28 . . . cord-007796-zggk0x2q 301 1 This this DT cord-007796-zggk0x2q 301 2 reactivation reactivation NN cord-007796-zggk0x2q 301 3 also also RB cord-007796-zggk0x2q 301 4 occurs occur VBZ cord-007796-zggk0x2q 301 5 with with IN cord-007796-zggk0x2q 301 6 Epstein Epstein NNP cord-007796-zggk0x2q 301 7 Barr Barr NNP cord-007796-zggk0x2q 301 8 virus virus NN cord-007796-zggk0x2q 301 9 ( ( -LRB- cord-007796-zggk0x2q 301 10 EBV EBV NNP cord-007796-zggk0x2q 301 11 ) ) -RRB- cord-007796-zggk0x2q 301 12 , , , cord-007796-zggk0x2q 301 13 human human JJ cord-007796-zggk0x2q 301 14 herpes herpes NN cord-007796-zggk0x2q 301 15 virus virus NN cord-007796-zggk0x2q 301 16 ( ( -LRB- cord-007796-zggk0x2q 301 17 HHV)-6 HHV)-6 NNP cord-007796-zggk0x2q 301 18 , , , cord-007796-zggk0x2q 301 19 -7 -7 NNP cord-007796-zggk0x2q 301 20 , , , cord-007796-zggk0x2q 301 21 and and CC cord-007796-zggk0x2q 301 22 -8 -8 NNP cord-007796-zggk0x2q 301 23 , , , cord-007796-zggk0x2q 301 24 although although IN cord-007796-zggk0x2q 301 25 these these DT cord-007796-zggk0x2q 301 26 are be VBP cord-007796-zggk0x2q 301 27 much much RB cord-007796-zggk0x2q 301 28 less less RBR cord-007796-zggk0x2q 301 29 frequent frequent JJ cord-007796-zggk0x2q 301 30 causative causative JJ cord-007796-zggk0x2q 301 31 agents agent NNS cord-007796-zggk0x2q 301 32 of of IN cord-007796-zggk0x2q 301 33 pneumonia pneumonia NN cord-007796-zggk0x2q 301 34 . . . cord-007796-zggk0x2q 302 1 The the DT cord-007796-zggk0x2q 302 2 innate innate JJ cord-007796-zggk0x2q 302 3 immune immune JJ cord-007796-zggk0x2q 302 4 defense defense NN cord-007796-zggk0x2q 302 5 to to IN cord-007796-zggk0x2q 302 6 viral viral JJ cord-007796-zggk0x2q 302 7 respiratory respiratory JJ cord-007796-zggk0x2q 302 8 tract tract NN cord-007796-zggk0x2q 302 9 infections infection NNS cord-007796-zggk0x2q 302 10 consists consist VBZ cord-007796-zggk0x2q 302 11 of of IN cord-007796-zggk0x2q 302 12 the the DT cord-007796-zggk0x2q 302 13 mucosal mucosal JJ cord-007796-zggk0x2q 302 14 layer layer NN cord-007796-zggk0x2q 302 15 , , , cord-007796-zggk0x2q 302 16 type type NN cord-007796-zggk0x2q 302 17 1 1 CD cord-007796-zggk0x2q 302 18 interferons interferon NNS cord-007796-zggk0x2q 302 19 , , , cord-007796-zggk0x2q 302 20 activated activate VBN cord-007796-zggk0x2q 302 21 phagocytes phagocyte NNS cord-007796-zggk0x2q 302 22 , , , cord-007796-zggk0x2q 302 23 and and CC cord-007796-zggk0x2q 302 24 NK nk NN cord-007796-zggk0x2q 302 25 - - HYPH cord-007796-zggk0x2q 302 26 cells cell NNS cord-007796-zggk0x2q 302 27 . . . cord-007796-zggk0x2q 303 1 The the DT cord-007796-zggk0x2q 303 2 impact impact NN cord-007796-zggk0x2q 303 3 of of IN cord-007796-zggk0x2q 303 4 primary primary JJ cord-007796-zggk0x2q 303 5 defects defect NNS cord-007796-zggk0x2q 303 6 in in IN cord-007796-zggk0x2q 303 7 the the DT cord-007796-zggk0x2q 303 8 innate innate JJ cord-007796-zggk0x2q 303 9 immune immune JJ cord-007796-zggk0x2q 303 10 defense defense NN cord-007796-zggk0x2q 303 11 has have VBZ cord-007796-zggk0x2q 303 12 not not RB cord-007796-zggk0x2q 303 13 been be VBN cord-007796-zggk0x2q 303 14 well well RB cord-007796-zggk0x2q 303 15 documented document VBN cord-007796-zggk0x2q 303 16 . . . cord-007796-zggk0x2q 304 1 Phagocyte Phagocyte NNP cord-007796-zggk0x2q 304 2 defects defect NNS cord-007796-zggk0x2q 304 3 are be VBP cord-007796-zggk0x2q 304 4 primarily primarily RB cord-007796-zggk0x2q 304 5 related relate VBN cord-007796-zggk0x2q 304 6 to to IN cord-007796-zggk0x2q 304 7 a a DT cord-007796-zggk0x2q 304 8 higher high JJR cord-007796-zggk0x2q 304 9 incidence incidence NN cord-007796-zggk0x2q 304 10 of of IN cord-007796-zggk0x2q 304 11 bacterial bacterial JJ cord-007796-zggk0x2q 304 12 infections infection NNS cord-007796-zggk0x2q 304 13 . . . cord-007796-zggk0x2q 305 1 One one CD cord-007796-zggk0x2q 305 2 indication indication NN cord-007796-zggk0x2q 305 3 that that IN cord-007796-zggk0x2q 305 4 impaired impaired JJ cord-007796-zggk0x2q 305 5 phagocyte phagocyte NNP cord-007796-zggk0x2q 305 6 function function NN cord-007796-zggk0x2q 305 7 also also RB cord-007796-zggk0x2q 305 8 leads lead VBZ cord-007796-zggk0x2q 305 9 to to IN cord-007796-zggk0x2q 305 10 increased increase VBN cord-007796-zggk0x2q 305 11 severity severity NN cord-007796-zggk0x2q 305 12 of of IN cord-007796-zggk0x2q 305 13 respiratory respiratory JJ cord-007796-zggk0x2q 305 14 viral viral JJ cord-007796-zggk0x2q 305 15 infection infection NN cord-007796-zggk0x2q 305 16 can can MD cord-007796-zggk0x2q 305 17 be be VB cord-007796-zggk0x2q 305 18 derived derive VBN cord-007796-zggk0x2q 305 19 from from IN cord-007796-zggk0x2q 305 20 a a DT cord-007796-zggk0x2q 305 21 report report NN cord-007796-zggk0x2q 305 22 of of IN cord-007796-zggk0x2q 305 23 severe severe JJ cord-007796-zggk0x2q 305 24 abnormalities abnormality NNS cord-007796-zggk0x2q 305 25 on on IN cord-007796-zggk0x2q 305 26 lung lung NN cord-007796-zggk0x2q 305 27 - - HYPH cord-007796-zggk0x2q 305 28 CT CT NNP cord-007796-zggk0x2q 305 29 - - HYPH cord-007796-zggk0x2q 305 30 scans scan NNS cord-007796-zggk0x2q 305 31 of of IN cord-007796-zggk0x2q 305 32 RSV RSV NNP cord-007796-zggk0x2q 305 33 patients patient NNS cord-007796-zggk0x2q 305 34 with with IN cord-007796-zggk0x2q 305 35 phagocyte phagocyte NNP cord-007796-zggk0x2q 305 36 defects defect NNS cord-007796-zggk0x2q 305 37 ( ( -LRB- cord-007796-zggk0x2q 305 38 Uzel Uzel NNP cord-007796-zggk0x2q 305 39 et et NNP cord-007796-zggk0x2q 305 40 al al NNP cord-007796-zggk0x2q 305 41 . . NNP cord-007796-zggk0x2q 305 42 , , , cord-007796-zggk0x2q 305 43 2000 2000 CD cord-007796-zggk0x2q 305 44 ) ) -RRB- cord-007796-zggk0x2q 305 45 . . . cord-007796-zggk0x2q 306 1 Interferon interferon NN cord-007796-zggk0x2q 306 2 - - HYPH cord-007796-zggk0x2q 306 3 gamma gamma NN cord-007796-zggk0x2q 306 4 receptor receptor NN cord-007796-zggk0x2q 306 5 deficiency deficiency NN cord-007796-zggk0x2q 306 6 , , , cord-007796-zggk0x2q 306 7 which which WDT cord-007796-zggk0x2q 306 8 may may MD cord-007796-zggk0x2q 306 9 have have VB cord-007796-zggk0x2q 306 10 implications implication NNS cord-007796-zggk0x2q 306 11 for for IN cord-007796-zggk0x2q 306 12 both both CC cord-007796-zggk0x2q 306 13 the the DT cord-007796-zggk0x2q 306 14 adaptive adaptive JJ cord-007796-zggk0x2q 306 15 and and CC cord-007796-zggk0x2q 306 16 innate innate JJ cord-007796-zggk0x2q 306 17 immune immune JJ cord-007796-zggk0x2q 306 18 system system NN cord-007796-zggk0x2q 306 19 , , , cord-007796-zggk0x2q 306 20 has have VBZ cord-007796-zggk0x2q 306 21 also also RB cord-007796-zggk0x2q 306 22 been be VBN cord-007796-zggk0x2q 306 23 associated associate VBN cord-007796-zggk0x2q 306 24 with with IN cord-007796-zggk0x2q 306 25 increased increase VBN cord-007796-zggk0x2q 306 26 susceptibility susceptibility NN cord-007796-zggk0x2q 306 27 to to IN cord-007796-zggk0x2q 306 28 viral viral JJ cord-007796-zggk0x2q 306 29 respiratory respiratory JJ cord-007796-zggk0x2q 306 30 pathogens pathogen NNS cord-007796-zggk0x2q 306 31 ( ( -LRB- cord-007796-zggk0x2q 306 32 Dorman Dorman NNP cord-007796-zggk0x2q 306 33 et et NNP cord-007796-zggk0x2q 306 34 al al NNP cord-007796-zggk0x2q 306 35 . . NNP cord-007796-zggk0x2q 306 36 , , , cord-007796-zggk0x2q 306 37 1999 1999 CD cord-007796-zggk0x2q 306 38 ) ) -RRB- cord-007796-zggk0x2q 306 39 . . . cord-007796-zggk0x2q 307 1 Chronic chronic JJ cord-007796-zggk0x2q 307 2 lung lung NN cord-007796-zggk0x2q 307 3 disease disease NN cord-007796-zggk0x2q 307 4 also also RB cord-007796-zggk0x2q 307 5 increases increase VBZ cord-007796-zggk0x2q 307 6 susceptibility susceptibility NN cord-007796-zggk0x2q 307 7 to to IN cord-007796-zggk0x2q 307 8 respiratory respiratory JJ cord-007796-zggk0x2q 307 9 viruses virus NNS cord-007796-zggk0x2q 307 10 ( ( -LRB- cord-007796-zggk0x2q 307 11 Meert Meert NNP cord-007796-zggk0x2q 307 12 et et NNP cord-007796-zggk0x2q 307 13 al al NNP cord-007796-zggk0x2q 307 14 . . NNP cord-007796-zggk0x2q 307 15 , , , cord-007796-zggk0x2q 307 16 1989 1989 CD cord-007796-zggk0x2q 307 17 ; ; : cord-007796-zggk0x2q 307 18 Griffin Griffin NNP cord-007796-zggk0x2q 307 19 et et NNP cord-007796-zggk0x2q 307 20 al al NNP cord-007796-zggk0x2q 307 21 . . NNP cord-007796-zggk0x2q 307 22 , , , cord-007796-zggk0x2q 307 23 2002 2002 CD cord-007796-zggk0x2q 307 24 ) ) -RRB- cord-007796-zggk0x2q 307 25 . . . cord-007796-zggk0x2q 308 1 Premature premature JJ cord-007796-zggk0x2q 308 2 patients patient NNS cord-007796-zggk0x2q 308 3 with with IN cord-007796-zggk0x2q 308 4 bronchopulmonary bronchopulmonary JJ cord-007796-zggk0x2q 308 5 dysplasia dysplasia NN cord-007796-zggk0x2q 308 6 are be VBP cord-007796-zggk0x2q 308 7 candidates candidate NNS cord-007796-zggk0x2q 308 8 for for IN cord-007796-zggk0x2q 308 9 RSV RSV NNP cord-007796-zggk0x2q 308 10 - - HYPH cord-007796-zggk0x2q 308 11 immunoprophylaxis immunoprophylaxis NNP cord-007796-zggk0x2q 308 12 because because IN cord-007796-zggk0x2q 308 13 of of IN cord-007796-zggk0x2q 308 14 their -PRON- PRP$ cord-007796-zggk0x2q 308 15 increased increase VBN cord-007796-zggk0x2q 308 16 risk risk NN cord-007796-zggk0x2q 308 17 of of IN cord-007796-zggk0x2q 308 18 developing develop VBG cord-007796-zggk0x2q 308 19 severe severe JJ cord-007796-zggk0x2q 308 20 lower low JJR cord-007796-zggk0x2q 308 21 respiratory respiratory JJ cord-007796-zggk0x2q 308 22 tract tract NN cord-007796-zggk0x2q 308 23 infections infection NNS cord-007796-zggk0x2q 308 24 . . . cord-007796-zggk0x2q 309 1 In in IN cord-007796-zggk0x2q 309 2 children child NNS cord-007796-zggk0x2q 309 3 with with IN cord-007796-zggk0x2q 309 4 cystic cystic JJ cord-007796-zggk0x2q 309 5 fibrosis fibrosis NN cord-007796-zggk0x2q 309 6 ( ( -LRB- cord-007796-zggk0x2q 309 7 CF CF NNP cord-007796-zggk0x2q 309 8 ) ) -RRB- cord-007796-zggk0x2q 309 9 , , , cord-007796-zggk0x2q 309 10 39 39 CD cord-007796-zggk0x2q 309 11 % % NN cord-007796-zggk0x2q 309 12 are be VBP cord-007796-zggk0x2q 309 13 already already RB cord-007796-zggk0x2q 309 14 hospitalized hospitalize VBN cord-007796-zggk0x2q 309 15 with with IN cord-007796-zggk0x2q 309 16 respiratory respiratory JJ cord-007796-zggk0x2q 309 17 virus virus NN cord-007796-zggk0x2q 309 18 infection infection NN cord-007796-zggk0x2q 309 19 in in IN cord-007796-zggk0x2q 309 20 their -PRON- PRP$ cord-007796-zggk0x2q 309 21 first first JJ cord-007796-zggk0x2q 309 22 year year NN cord-007796-zggk0x2q 309 23 of of IN cord-007796-zggk0x2q 309 24 life life NN cord-007796-zggk0x2q 309 25 . . . cord-007796-zggk0x2q 310 1 Furthermore furthermore RB cord-007796-zggk0x2q 310 2 , , , cord-007796-zggk0x2q 310 3 there there EX cord-007796-zggk0x2q 310 4 is be VBZ cord-007796-zggk0x2q 310 5 a a DT cord-007796-zggk0x2q 310 6 correlation correlation NN cord-007796-zggk0x2q 310 7 between between IN cord-007796-zggk0x2q 310 8 viral viral JJ cord-007796-zggk0x2q 310 9 infections infection NNS cord-007796-zggk0x2q 310 10 in in IN cord-007796-zggk0x2q 310 11 infancy infancy NN cord-007796-zggk0x2q 310 12 and and CC cord-007796-zggk0x2q 310 13 disease disease NN cord-007796-zggk0x2q 310 14 progression progression NN cord-007796-zggk0x2q 310 15 . . . cord-007796-zggk0x2q 311 1 Infants infant NNS cord-007796-zggk0x2q 311 2 with with IN cord-007796-zggk0x2q 311 3 CF cf NN cord-007796-zggk0x2q 311 4 suffering suffer VBG cord-007796-zggk0x2q 311 5 from from IN cord-007796-zggk0x2q 311 6 a a DT cord-007796-zggk0x2q 311 7 respiratory respiratory JJ cord-007796-zggk0x2q 311 8 virus virus NN cord-007796-zggk0x2q 311 9 infection infection NN cord-007796-zggk0x2q 311 10 are be VBP cord-007796-zggk0x2q 311 11 at at IN cord-007796-zggk0x2q 311 12 significant significant JJ cord-007796-zggk0x2q 311 13 risk risk NN cord-007796-zggk0x2q 311 14 for for IN cord-007796-zggk0x2q 311 15 lower low JJR cord-007796-zggk0x2q 311 16 respiratory respiratory JJ cord-007796-zggk0x2q 311 17 tract tract NN cord-007796-zggk0x2q 311 18 disease disease NN cord-007796-zggk0x2q 311 19 , , , cord-007796-zggk0x2q 311 20 hospitalization hospitalization NN cord-007796-zggk0x2q 311 21 , , , cord-007796-zggk0x2q 311 22 and and CC cord-007796-zggk0x2q 311 23 deterioration deterioration NN cord-007796-zggk0x2q 311 24 in in IN cord-007796-zggk0x2q 311 25 lung lung NN cord-007796-zggk0x2q 311 26 function function NN cord-007796-zggk0x2q 311 27 that that WDT cord-007796-zggk0x2q 311 28 persists persist VBZ cord-007796-zggk0x2q 311 29 months month NNS cord-007796-zggk0x2q 311 30 after after IN cord-007796-zggk0x2q 311 31 the the DT cord-007796-zggk0x2q 311 32 acute acute JJ cord-007796-zggk0x2q 311 33 illness illness NN cord-007796-zggk0x2q 312 1 ( ( -LRB- cord-007796-zggk0x2q 312 2 Hiatt Hiatt NNP cord-007796-zggk0x2q 312 3 et et NNP cord-007796-zggk0x2q 312 4 al al NNP cord-007796-zggk0x2q 312 5 . . NNP cord-007796-zggk0x2q 312 6 , , , cord-007796-zggk0x2q 312 7 1999 1999 CD cord-007796-zggk0x2q 312 8 ) ) -RRB- cord-007796-zggk0x2q 312 9 . . . cord-007796-zggk0x2q 313 1 CF CF NNP cord-007796-zggk0x2q 313 2 infants infant NNS cord-007796-zggk0x2q 313 3 were be VBD cord-007796-zggk0x2q 313 4 found find VBN cord-007796-zggk0x2q 313 5 to to TO cord-007796-zggk0x2q 313 6 be be VB cord-007796-zggk0x2q 313 7 four four CD cord-007796-zggk0x2q 313 8 times time NNS cord-007796-zggk0x2q 313 9 more more RBR cord-007796-zggk0x2q 313 10 likely likely JJ cord-007796-zggk0x2q 313 11 to to TO cord-007796-zggk0x2q 313 12 develop develop VB cord-007796-zggk0x2q 313 13 an an DT cord-007796-zggk0x2q 313 14 LRTI LRTI NNS cord-007796-zggk0x2q 313 15 compared compare VBN cord-007796-zggk0x2q 313 16 with with IN cord-007796-zggk0x2q 313 17 controls control NNS cord-007796-zggk0x2q 313 18 . . . cord-007796-zggk0x2q 314 1 It -PRON- PRP cord-007796-zggk0x2q 314 2 has have VBZ cord-007796-zggk0x2q 314 3 been be VBN cord-007796-zggk0x2q 314 4 shown show VBN cord-007796-zggk0x2q 314 5 that that IN cord-007796-zggk0x2q 314 6 CFderived CFderived NNP cord-007796-zggk0x2q 314 7 airway airway NN cord-007796-zggk0x2q 314 8 epithelial epithelial JJ cord-007796-zggk0x2q 314 9 cells cell NNS cord-007796-zggk0x2q 314 10 allow allow VBP cord-007796-zggk0x2q 314 11 a a DT cord-007796-zggk0x2q 314 12 higher high JJR cord-007796-zggk0x2q 314 13 degree degree NN cord-007796-zggk0x2q 314 14 of of IN cord-007796-zggk0x2q 314 15 PIV PIV NNP cord-007796-zggk0x2q 314 16 replication replication NN cord-007796-zggk0x2q 314 17 and and CC cord-007796-zggk0x2q 314 18 have have VBP cord-007796-zggk0x2q 314 19 an an DT cord-007796-zggk0x2q 314 20 increased increase VBN cord-007796-zggk0x2q 314 21 production production NN cord-007796-zggk0x2q 314 22 of of IN cord-007796-zggk0x2q 314 23 pro pro JJ cord-007796-zggk0x2q 314 24 - - JJ cord-007796-zggk0x2q 314 25 inflammatory inflammatory JJ cord-007796-zggk0x2q 314 26 cytokines cytokine NNS cord-007796-zggk0x2q 315 1 ( ( -LRB- cord-007796-zggk0x2q 315 2 Zheng Zheng NNP cord-007796-zggk0x2q 315 3 et et NNP cord-007796-zggk0x2q 315 4 al al NNP cord-007796-zggk0x2q 315 5 . . NNP cord-007796-zggk0x2q 315 6 , , , cord-007796-zggk0x2q 315 7 2003 2003 CD cord-007796-zggk0x2q 315 8 ) ) -RRB- cord-007796-zggk0x2q 315 9 . . . cord-007796-zggk0x2q 316 1 CFderived cfderived JJ cord-007796-zggk0x2q 316 2 epithelial epithelial JJ cord-007796-zggk0x2q 316 3 cells cell NNS cord-007796-zggk0x2q 316 4 are be VBP cord-007796-zggk0x2q 316 5 also also RB cord-007796-zggk0x2q 316 6 unable unable JJ cord-007796-zggk0x2q 316 7 to to TO cord-007796-zggk0x2q 316 8 express express VB cord-007796-zggk0x2q 316 9 NO no JJ cord-007796-zggk0x2q 316 10 - - HYPH cord-007796-zggk0x2q 316 11 synthase synthase NN cord-007796-zggk0x2q 316 12 2 2 CD cord-007796-zggk0x2q 316 13 , , , cord-007796-zggk0x2q 316 14 which which WDT cord-007796-zggk0x2q 316 15 results result VBZ cord-007796-zggk0x2q 316 16 in in IN cord-007796-zggk0x2q 316 17 a a DT cord-007796-zggk0x2q 316 18 decrease decrease NN cord-007796-zggk0x2q 316 19 production production NN cord-007796-zggk0x2q 316 20 of of IN cord-007796-zggk0x2q 316 21 nitric nitric NN cord-007796-zggk0x2q 316 22 oxide oxide NN cord-007796-zggk0x2q 316 23 ( ( -LRB- cord-007796-zggk0x2q 316 24 NO no UH cord-007796-zggk0x2q 316 25 ) ) -RRB- cord-007796-zggk0x2q 316 26 , , , cord-007796-zggk0x2q 316 27 which which WDT cord-007796-zggk0x2q 316 28 has have VBZ cord-007796-zggk0x2q 316 29 antiviral antiviral JJ cord-007796-zggk0x2q 316 30 capacity capacity NN cord-007796-zggk0x2q 316 31 , , , cord-007796-zggk0x2q 316 32 reducing reduce VBG cord-007796-zggk0x2q 316 33 effects effect NNS cord-007796-zggk0x2q 316 34 on on IN cord-007796-zggk0x2q 316 35 replication replication NN cord-007796-zggk0x2q 316 36 . . . cord-007796-zggk0x2q 317 1 Furthermore furthermore RB cord-007796-zggk0x2q 317 2 , , , cord-007796-zggk0x2q 317 3 in in IN cord-007796-zggk0x2q 317 4 CF cf NN cord-007796-zggk0x2q 317 5 - - HYPH cord-007796-zggk0x2q 317 6 cells cell NNS cord-007796-zggk0x2q 317 7 there there EX cord-007796-zggk0x2q 317 8 is be VBZ cord-007796-zggk0x2q 317 9 no no DT cord-007796-zggk0x2q 317 10 viral viral JJ cord-007796-zggk0x2q 317 11 induction induction NN cord-007796-zggk0x2q 317 12 of of IN cord-007796-zggk0x2q 317 13 2Ј5Јoligoadenylate 2ј5јoligoadenylate CD cord-007796-zggk0x2q 317 14 synthetase synthetase NNP cord-007796-zggk0x2q 317 15 ( ( -LRB- cord-007796-zggk0x2q 317 16 OAS OAS NNP cord-007796-zggk0x2q 317 17 ) ) -RRB- cord-007796-zggk0x2q 317 18 , , , cord-007796-zggk0x2q 317 19 an an DT cord-007796-zggk0x2q 317 20 enzyme enzyme NN cord-007796-zggk0x2q 317 21 that that WDT cord-007796-zggk0x2q 317 22 is be VBZ cord-007796-zggk0x2q 317 23 normally normally RB cord-007796-zggk0x2q 317 24 induced induce VBN cord-007796-zggk0x2q 317 25 by by IN cord-007796-zggk0x2q 317 26 dsRNA dsrna NN cord-007796-zggk0x2q 317 27 and and CC cord-007796-zggk0x2q 317 28 IFN- IFN- NNP cord-007796-zggk0x2q 317 29 ␥ ␥ ADD cord-007796-zggk0x2q 317 30 . . . cord-007796-zggk0x2q 318 1 OAS OAS NNP cord-007796-zggk0x2q 318 2 is be VBZ cord-007796-zggk0x2q 318 3 involved involve VBN cord-007796-zggk0x2q 318 4 in in IN cord-007796-zggk0x2q 318 5 inhibition inhibition NN cord-007796-zggk0x2q 318 6 of of IN cord-007796-zggk0x2q 318 7 cellular cellular JJ cord-007796-zggk0x2q 318 8 protein protein NN cord-007796-zggk0x2q 318 9 synthesis synthesis NN cord-007796-zggk0x2q 318 10 , , , cord-007796-zggk0x2q 318 11 thereby thereby RB cord-007796-zggk0x2q 318 12 inhibiting inhibit VBG cord-007796-zggk0x2q 318 13 viral viral JJ cord-007796-zggk0x2q 318 14 replication replication NN cord-007796-zggk0x2q 318 15 . . . cord-007796-zggk0x2q 319 1 Respiratory respiratory JJ cord-007796-zggk0x2q 319 2 viruses virus NNS cord-007796-zggk0x2q 319 3 can can MD cord-007796-zggk0x2q 319 4 be be VB cord-007796-zggk0x2q 319 5 isolated isolate VBN cord-007796-zggk0x2q 319 6 from from IN cord-007796-zggk0x2q 319 7 the the DT cord-007796-zggk0x2q 319 8 secretions secretion NNS cord-007796-zggk0x2q 319 9 of of IN cord-007796-zggk0x2q 319 10 approximately approximately RB cord-007796-zggk0x2q 319 11 75 75 CD cord-007796-zggk0x2q 319 12 % % NN cord-007796-zggk0x2q 319 13 of of IN cord-007796-zggk0x2q 319 14 children child NNS cord-007796-zggk0x2q 319 15 and and CC cord-007796-zggk0x2q 319 16 of of IN cord-007796-zggk0x2q 319 17 more more JJR cord-007796-zggk0x2q 319 18 than than IN cord-007796-zggk0x2q 319 19 half half NN cord-007796-zggk0x2q 319 20 of of IN cord-007796-zggk0x2q 319 21 adults adult NNS cord-007796-zggk0x2q 319 22 during during IN cord-007796-zggk0x2q 319 23 asthma asthma NN cord-007796-zggk0x2q 319 24 exacerbations exacerbation NNS cord-007796-zggk0x2q 319 25 ( ( -LRB- cord-007796-zggk0x2q 319 26 Johnston Johnston NNP cord-007796-zggk0x2q 319 27 et et NNP cord-007796-zggk0x2q 319 28 al al NNP cord-007796-zggk0x2q 319 29 . . NNP cord-007796-zggk0x2q 319 30 , , , cord-007796-zggk0x2q 319 31 1995 1995 CD cord-007796-zggk0x2q 319 32 ; ; : cord-007796-zggk0x2q 319 33 Lemanske Lemanske NNP cord-007796-zggk0x2q 319 34 , , , cord-007796-zggk0x2q 319 35 2003 2003 CD cord-007796-zggk0x2q 319 36 ) ) -RRB- cord-007796-zggk0x2q 319 37 . . . cord-007796-zggk0x2q 320 1 Recently recently RB cord-007796-zggk0x2q 320 2 , , , cord-007796-zggk0x2q 320 3 COPD COPD NNP cord-007796-zggk0x2q 320 4 exacerbations exacerbation NNS cord-007796-zggk0x2q 320 5 have have VBP cord-007796-zggk0x2q 320 6 also also RB cord-007796-zggk0x2q 320 7 been be VBN cord-007796-zggk0x2q 320 8 attributed attribute VBN cord-007796-zggk0x2q 320 9 to to IN cord-007796-zggk0x2q 320 10 viral viral JJ cord-007796-zggk0x2q 320 11 infection infection NN cord-007796-zggk0x2q 320 12 by by IN cord-007796-zggk0x2q 320 13 rhinovirus rhinovirus NN cord-007796-zggk0x2q 320 14 , , , cord-007796-zggk0x2q 320 15 RSV RSV NNP cord-007796-zggk0x2q 320 16 , , , cord-007796-zggk0x2q 320 17 and and CC cord-007796-zggk0x2q 320 18 PIV PIV NNP cord-007796-zggk0x2q 320 19 ( ( -LRB- cord-007796-zggk0x2q 320 20 Seemungal Seemungal NNP cord-007796-zggk0x2q 320 21 and and CC cord-007796-zggk0x2q 320 22 Wedzicha Wedzicha NNP cord-007796-zggk0x2q 320 23 , , , cord-007796-zggk0x2q 320 24 2003 2003 CD cord-007796-zggk0x2q 320 25 ) ) -RRB- cord-007796-zggk0x2q 320 26 . . . cord-007796-zggk0x2q 321 1 The the DT cord-007796-zggk0x2q 321 2 underlying underlie VBG cord-007796-zggk0x2q 321 3 mechanisms mechanism NNS cord-007796-zggk0x2q 321 4 for for IN cord-007796-zggk0x2q 321 5 this this DT cord-007796-zggk0x2q 321 6 are be VBP cord-007796-zggk0x2q 321 7 , , , cord-007796-zggk0x2q 321 8 however however RB cord-007796-zggk0x2q 321 9 , , , cord-007796-zggk0x2q 321 10 still still RB cord-007796-zggk0x2q 321 11 a a DT cord-007796-zggk0x2q 321 12 matter matter NN cord-007796-zggk0x2q 321 13 of of IN cord-007796-zggk0x2q 321 14 debate debate NN cord-007796-zggk0x2q 321 15 . . . cord-007796-zggk0x2q 322 1 From from IN cord-007796-zggk0x2q 322 2 experimental experimental JJ cord-007796-zggk0x2q 322 3 rhinovirus rhinovirus NN cord-007796-zggk0x2q 322 4 ( ( -LRB- cord-007796-zggk0x2q 322 5 RV rv NN cord-007796-zggk0x2q 322 6 ) ) -RRB- cord-007796-zggk0x2q 322 7 infections infection NNS cord-007796-zggk0x2q 322 8 in in IN cord-007796-zggk0x2q 322 9 humans human NNS cord-007796-zggk0x2q 322 10 , , , cord-007796-zggk0x2q 322 11 it -PRON- PRP cord-007796-zggk0x2q 322 12 has have VBZ cord-007796-zggk0x2q 322 13 been be VBN cord-007796-zggk0x2q 322 14 shown show VBN cord-007796-zggk0x2q 322 15 that that IN cord-007796-zggk0x2q 322 16 RV rv NN cord-007796-zggk0x2q 322 17 infection infection NN cord-007796-zggk0x2q 322 18 causes cause VBZ cord-007796-zggk0x2q 322 19 increased increase VBN cord-007796-zggk0x2q 322 20 bronchoconstriction bronchoconstriction NN cord-007796-zggk0x2q 322 21 in in IN cord-007796-zggk0x2q 322 22 atopic atopic JJ cord-007796-zggk0x2q 322 23 non non JJ cord-007796-zggk0x2q 322 24 - - JJ cord-007796-zggk0x2q 322 25 asthmatic asthmatic JJ cord-007796-zggk0x2q 322 26 and and CC cord-007796-zggk0x2q 322 27 asthmatic asthmatic JJ cord-007796-zggk0x2q 322 28 individuals individual NNS cord-007796-zggk0x2q 322 29 , , , cord-007796-zggk0x2q 322 30 while while IN cord-007796-zggk0x2q 322 31 symptoms symptom NNS cord-007796-zggk0x2q 322 32 in in IN cord-007796-zggk0x2q 322 33 normal normal JJ cord-007796-zggk0x2q 322 34 individuals individual NNS cord-007796-zggk0x2q 322 35 are be VBP cord-007796-zggk0x2q 322 36 relatively relatively RB cord-007796-zggk0x2q 322 37 mild mild JJ cord-007796-zggk0x2q 322 38 . . . cord-007796-zggk0x2q 323 1 This this DT cord-007796-zggk0x2q 323 2 implies imply VBZ cord-007796-zggk0x2q 323 3 that that IN cord-007796-zggk0x2q 323 4 induction induction NN cord-007796-zggk0x2q 323 5 of of IN cord-007796-zggk0x2q 323 6 a a DT cord-007796-zggk0x2q 323 7 wheezing wheezing JJ cord-007796-zggk0x2q 323 8 episode episode NN cord-007796-zggk0x2q 323 9 requires require VBZ cord-007796-zggk0x2q 323 10 both both DT cord-007796-zggk0x2q 323 11 RV RV NNP cord-007796-zggk0x2q 323 12 infection infection NN cord-007796-zggk0x2q 323 13 and and CC cord-007796-zggk0x2q 323 14 a a DT cord-007796-zggk0x2q 323 15 preexisting preexisting JJ cord-007796-zggk0x2q 323 16 tendency tendency NN cord-007796-zggk0x2q 323 17 to to TO cord-007796-zggk0x2q 323 18 develop develop VB cord-007796-zggk0x2q 323 19 allergic allergic JJ cord-007796-zggk0x2q 323 20 or or CC cord-007796-zggk0x2q 323 21 asthmatic asthmatic JJ cord-007796-zggk0x2q 323 22 disease disease NN cord-007796-zggk0x2q 323 23 ( ( -LRB- cord-007796-zggk0x2q 323 24 Message message NN cord-007796-zggk0x2q 323 25 and and CC cord-007796-zggk0x2q 323 26 Johnston Johnston NNP cord-007796-zggk0x2q 323 27 , , , cord-007796-zggk0x2q 323 28 2001 2001 CD cord-007796-zggk0x2q 323 29 ) ) -RRB- cord-007796-zggk0x2q 323 30 . . . cord-007796-zggk0x2q 324 1 RV rv NN cord-007796-zggk0x2q 324 2 - - HYPH cord-007796-zggk0x2q 324 3 specific specific JJ cord-007796-zggk0x2q 324 4 T t NN cord-007796-zggk0x2q 324 5 - - HYPH cord-007796-zggk0x2q 324 6 cell cell NN cord-007796-zggk0x2q 324 7 responses response NNS cord-007796-zggk0x2q 324 8 can can MD cord-007796-zggk0x2q 324 9 be be VB cord-007796-zggk0x2q 324 10 activated activate VBN cord-007796-zggk0x2q 324 11 by by IN cord-007796-zggk0x2q 324 12 either either DT cord-007796-zggk0x2q 324 13 serotype serotype NN cord-007796-zggk0x2q 324 14 - - HYPH cord-007796-zggk0x2q 324 15 specific specific JJ cord-007796-zggk0x2q 324 16 or or CC cord-007796-zggk0x2q 324 17 shared share VBN cord-007796-zggk0x2q 324 18 viral viral JJ cord-007796-zggk0x2q 324 19 epitopes epitope NNS cord-007796-zggk0x2q 324 20 . . . cord-007796-zggk0x2q 325 1 Cross cross NN cord-007796-zggk0x2q 325 2 - - NN cord-007796-zggk0x2q 325 3 reactivity reactivity NN cord-007796-zggk0x2q 325 4 between between IN cord-007796-zggk0x2q 325 5 RV rv NN cord-007796-zggk0x2q 325 6 - - HYPH cord-007796-zggk0x2q 325 7 subtypes subtype NNS cord-007796-zggk0x2q 325 8 could could MD cord-007796-zggk0x2q 325 9 result result VB cord-007796-zggk0x2q 325 10 in in IN cord-007796-zggk0x2q 325 11 vigorous vigorous JJ cord-007796-zggk0x2q 325 12 T t NN cord-007796-zggk0x2q 325 13 - - HYPH cord-007796-zggk0x2q 325 14 cell cell NN cord-007796-zggk0x2q 325 15 responses response NNS cord-007796-zggk0x2q 325 16 and and CC cord-007796-zggk0x2q 325 17 may may MD cord-007796-zggk0x2q 325 18 amplify amplify VB cord-007796-zggk0x2q 325 19 allergic allergic JJ cord-007796-zggk0x2q 325 20 inflammation inflammation NN cord-007796-zggk0x2q 325 21 . . . cord-007796-zggk0x2q 326 1 Other other JJ cord-007796-zggk0x2q 326 2 proposed propose VBN cord-007796-zggk0x2q 326 3 mechanisms mechanism NNS cord-007796-zggk0x2q 326 4 linking link VBG cord-007796-zggk0x2q 326 5 viral viral JJ cord-007796-zggk0x2q 326 6 infections infection NNS cord-007796-zggk0x2q 326 7 to to IN cord-007796-zggk0x2q 326 8 asthma asthma NN cord-007796-zggk0x2q 326 9 exacerbation exacerbation NN cord-007796-zggk0x2q 326 10 are be VBP cord-007796-zggk0x2q 326 11 epithelial epithelial JJ cord-007796-zggk0x2q 326 12 dysregulation dysregulation NN cord-007796-zggk0x2q 326 13 , , , cord-007796-zggk0x2q 326 14 airway airway NN cord-007796-zggk0x2q 326 15 remodeling remodeling NN cord-007796-zggk0x2q 326 16 , , , cord-007796-zggk0x2q 326 17 the the DT cord-007796-zggk0x2q 326 18 immune immune JJ cord-007796-zggk0x2q 326 19 response response NN cord-007796-zggk0x2q 326 20 to to IN cord-007796-zggk0x2q 326 21 virus virus NN cord-007796-zggk0x2q 326 22 , , , cord-007796-zggk0x2q 326 23 and and CC cord-007796-zggk0x2q 326 24 alterations alteration NNS cord-007796-zggk0x2q 326 25 of of IN cord-007796-zggk0x2q 326 26 neural neural JJ cord-007796-zggk0x2q 326 27 responses response NNS cord-007796-zggk0x2q 326 28 ( ( -LRB- cord-007796-zggk0x2q 326 29 Message Message NNP cord-007796-zggk0x2q 326 30 and and CC cord-007796-zggk0x2q 326 31 Johnston Johnston NNP cord-007796-zggk0x2q 326 32 , , , cord-007796-zggk0x2q 326 33 2001 2001 CD cord-007796-zggk0x2q 326 34 ; ; : cord-007796-zggk0x2q 326 35 Gern Gern NNP cord-007796-zggk0x2q 326 36 , , , cord-007796-zggk0x2q 326 37 2002 2002 CD cord-007796-zggk0x2q 326 38 ) ) -RRB- cord-007796-zggk0x2q 326 39 . . . cord-007796-zggk0x2q 327 1 Upregulation Upregulation NNP cord-007796-zggk0x2q 327 2 of of IN cord-007796-zggk0x2q 327 3 ICAM-1-expression icam-1-expression NN cord-007796-zggk0x2q 327 4 , , , cord-007796-zggk0x2q 327 5 which which WDT cord-007796-zggk0x2q 327 6 is be VBZ cord-007796-zggk0x2q 327 7 the the DT cord-007796-zggk0x2q 327 8 entry entry NN cord-007796-zggk0x2q 327 9 receptor receptor NN cord-007796-zggk0x2q 327 10 for for IN cord-007796-zggk0x2q 327 11 major major JJ cord-007796-zggk0x2q 327 12 group group NN cord-007796-zggk0x2q 327 13 rhinoviruses rhinovirus NNS cord-007796-zggk0x2q 327 14 , , , cord-007796-zggk0x2q 327 15 has have VBZ cord-007796-zggk0x2q 327 16 been be VBN cord-007796-zggk0x2q 327 17 found find VBN cord-007796-zggk0x2q 327 18 in in IN cord-007796-zggk0x2q 327 19 susceptible susceptible JJ cord-007796-zggk0x2q 327 20 individuals individual NNS cord-007796-zggk0x2q 327 21 . . . cord-007796-zggk0x2q 328 1 This this DT cord-007796-zggk0x2q 328 2 may may MD cord-007796-zggk0x2q 328 3 be be VB cord-007796-zggk0x2q 328 4 one one CD cord-007796-zggk0x2q 328 5 mechanism mechanism NN cord-007796-zggk0x2q 328 6 predisposing predispose VBG cord-007796-zggk0x2q 328 7 atopic atopic JJ cord-007796-zggk0x2q 328 8 individuals individual NNS cord-007796-zggk0x2q 328 9 to to IN cord-007796-zggk0x2q 328 10 RV rv NN cord-007796-zggk0x2q 328 11 - - HYPH cord-007796-zggk0x2q 328 12 induced induce VBN cord-007796-zggk0x2q 328 13 exacerbations exacerbation NNS cord-007796-zggk0x2q 328 14 . . . cord-007796-zggk0x2q 329 1 Rhinovirus rhinovirus NN cord-007796-zggk0x2q 329 2 can can MD cord-007796-zggk0x2q 329 3 induce induce VB cord-007796-zggk0x2q 329 4 a a DT cord-007796-zggk0x2q 329 5 number number NN cord-007796-zggk0x2q 329 6 of of IN cord-007796-zggk0x2q 329 7 inflammatory inflammatory JJ cord-007796-zggk0x2q 329 8 mediators mediator NNS cord-007796-zggk0x2q 329 9 ( ( -LRB- cord-007796-zggk0x2q 329 10 kinins kinin NNS cord-007796-zggk0x2q 329 11 , , , cord-007796-zggk0x2q 329 12 arachidonic arachidonic NN cord-007796-zggk0x2q 329 13 acid acid NN cord-007796-zggk0x2q 329 14 ) ) -RRB- cord-007796-zggk0x2q 329 15 and and CC cord-007796-zggk0x2q 329 16 cytokines cytokine NNS cord-007796-zggk0x2q 329 17 ( ( -LRB- cord-007796-zggk0x2q 329 18 e.g. e.g. RB cord-007796-zggk0x2q 329 19 , , , cord-007796-zggk0x2q 329 20 IL-1 IL-1 NNP cord-007796-zggk0x2q 329 21 , , , cord-007796-zggk0x2q 329 22 IL-6 IL-6 NNP cord-007796-zggk0x2q 329 23 , , , cord-007796-zggk0x2q 329 24 IFN- IFN- NNP cord-007796-zggk0x2q 329 25 ␣ ␣ NNP cord-007796-zggk0x2q 329 26 / / SYM cord-007796-zggk0x2q 329 27 ␤ ␤ NNP cord-007796-zggk0x2q 329 28 , , , cord-007796-zggk0x2q 329 29 GM GM NNP cord-007796-zggk0x2q 329 30 - - HYPH cord-007796-zggk0x2q 329 31 CSF CSF NNP cord-007796-zggk0x2q 329 32 , , , cord-007796-zggk0x2q 329 33 TNF- TNF- NNP cord-007796-zggk0x2q 329 34 ␣ ␣ NFP cord-007796-zggk0x2q 329 35 ) ) -RRB- cord-007796-zggk0x2q 329 36 that that WDT cord-007796-zggk0x2q 329 37 can can MD cord-007796-zggk0x2q 329 38 further further RB cord-007796-zggk0x2q 329 39 enhance enhance VB cord-007796-zggk0x2q 329 40 inflammation inflammation NN cord-007796-zggk0x2q 329 41 . . . cord-007796-zggk0x2q 330 1 Th1 th1 NN cord-007796-zggk0x2q 330 2 cytokines cytokine NNS cord-007796-zggk0x2q 330 3 seem seem VBP cord-007796-zggk0x2q 330 4 to to TO cord-007796-zggk0x2q 330 5 have have VB cord-007796-zggk0x2q 330 6 a a DT cord-007796-zggk0x2q 330 7 general general JJ cord-007796-zggk0x2q 330 8 antiviral antiviral JJ cord-007796-zggk0x2q 330 9 effect effect NN cord-007796-zggk0x2q 330 10 while while IN cord-007796-zggk0x2q 330 11 a a DT cord-007796-zggk0x2q 330 12 predominant predominant JJ cord-007796-zggk0x2q 330 13 Th2-cytokine Th2-cytokine NNP cord-007796-zggk0x2q 330 14 response response NN cord-007796-zggk0x2q 330 15 leads lead VBZ cord-007796-zggk0x2q 330 16 to to IN cord-007796-zggk0x2q 330 17 enhanced enhance VBN cord-007796-zggk0x2q 330 18 disease disease NN cord-007796-zggk0x2q 330 19 , , , cord-007796-zggk0x2q 330 20 failure failure NN cord-007796-zggk0x2q 330 21 to to TO cord-007796-zggk0x2q 330 22 clear clear VB cord-007796-zggk0x2q 330 23 the the DT cord-007796-zggk0x2q 330 24 virus virus NN cord-007796-zggk0x2q 330 25 , , , cord-007796-zggk0x2q 330 26 and and CC cord-007796-zggk0x2q 330 27 amplification amplification NN cord-007796-zggk0x2q 330 28 of of IN cord-007796-zggk0x2q 330 29 allergic allergic JJ cord-007796-zggk0x2q 330 30 inflammation inflammation NN cord-007796-zggk0x2q 330 31 ( ( -LRB- cord-007796-zggk0x2q 330 32 Message message NN cord-007796-zggk0x2q 330 33 and and CC cord-007796-zggk0x2q 330 34 Johnston Johnston NNP cord-007796-zggk0x2q 330 35 , , , cord-007796-zggk0x2q 330 36 2001 2001 CD cord-007796-zggk0x2q 330 37 ) ) -RRB- cord-007796-zggk0x2q 330 38 . . . cord-007796-zggk0x2q 331 1 Eosinophil eosinophil JJ cord-007796-zggk0x2q 331 2 numbers number NNS cord-007796-zggk0x2q 331 3 were be VBD cord-007796-zggk0x2q 331 4 found find VBN cord-007796-zggk0x2q 331 5 to to TO cord-007796-zggk0x2q 331 6 be be VB cord-007796-zggk0x2q 331 7 increased increase VBN cord-007796-zggk0x2q 331 8 in in IN cord-007796-zggk0x2q 331 9 bronchial bronchial JJ cord-007796-zggk0x2q 331 10 biopsies biopsy NNS cord-007796-zggk0x2q 331 11 from from IN cord-007796-zggk0x2q 331 12 both both CC cord-007796-zggk0x2q 331 13 healthy healthy JJ cord-007796-zggk0x2q 331 14 and and CC cord-007796-zggk0x2q 331 15 asthmatic asthmatic JJ cord-007796-zggk0x2q 331 16 human human JJ cord-007796-zggk0x2q 331 17 volunteers volunteer NNS cord-007796-zggk0x2q 331 18 after after IN cord-007796-zggk0x2q 331 19 experimental experimental JJ cord-007796-zggk0x2q 331 20 rhinovirus rhinovirus NN cord-007796-zggk0x2q 331 21 infection infection NN cord-007796-zggk0x2q 331 22 . . . cord-007796-zggk0x2q 332 1 This this DT cord-007796-zggk0x2q 332 2 cell cell NN cord-007796-zggk0x2q 332 3 type type NN cord-007796-zggk0x2q 332 4 is be VBZ cord-007796-zggk0x2q 332 5 associated associate VBN cord-007796-zggk0x2q 332 6 with with IN cord-007796-zggk0x2q 332 7 allergic allergic JJ cord-007796-zggk0x2q 332 8 inflammation inflammation NN cord-007796-zggk0x2q 332 9 in in IN cord-007796-zggk0x2q 332 10 the the DT cord-007796-zggk0x2q 332 11 lung lung NN cord-007796-zggk0x2q 332 12 . . . cord-007796-zggk0x2q 333 1 In in IN cord-007796-zggk0x2q 333 2 allergic allergic JJ cord-007796-zggk0x2q 333 3 rhinitis rhinitis NN cord-007796-zggk0x2q 333 4 patients patient NNS cord-007796-zggk0x2q 333 5 , , , cord-007796-zggk0x2q 333 6 the the DT cord-007796-zggk0x2q 333 7 increased increase VBN cord-007796-zggk0x2q 333 8 level level NN cord-007796-zggk0x2q 333 9 of of IN cord-007796-zggk0x2q 333 10 eosinophils eosinophil NNS cord-007796-zggk0x2q 333 11 in in IN cord-007796-zggk0x2q 333 12 BAL BAL NNP cord-007796-zggk0x2q 333 13 even even RB cord-007796-zggk0x2q 333 14 persisted persist VBD cord-007796-zggk0x2q 333 15 for for IN cord-007796-zggk0x2q 333 16 6 6 CD cord-007796-zggk0x2q 333 17 weeks week NNS cord-007796-zggk0x2q 333 18 . . . cord-007796-zggk0x2q 334 1 These these DT cord-007796-zggk0x2q 334 2 data datum NNS cord-007796-zggk0x2q 334 3 suggest suggest VBP cord-007796-zggk0x2q 334 4 a a DT cord-007796-zggk0x2q 334 5 potential potential JJ cord-007796-zggk0x2q 334 6 role role NN cord-007796-zggk0x2q 334 7 for for IN cord-007796-zggk0x2q 334 8 eosinophils eosinophil NNS cord-007796-zggk0x2q 334 9 in in IN cord-007796-zggk0x2q 334 10 virus virus NN cord-007796-zggk0x2q 334 11 - - HYPH cord-007796-zggk0x2q 334 12 induced induce VBN cord-007796-zggk0x2q 334 13 asthma asthma NN cord-007796-zggk0x2q 334 14 , , , cord-007796-zggk0x2q 334 15 which which WDT cord-007796-zggk0x2q 334 16 can can MD cord-007796-zggk0x2q 334 17 be be VB cord-007796-zggk0x2q 334 18 either either CC cord-007796-zggk0x2q 334 19 pathogenic pathogenic JJ cord-007796-zggk0x2q 334 20 or or CC cord-007796-zggk0x2q 334 21 protective protective JJ cord-007796-zggk0x2q 334 22 . . . cord-007796-zggk0x2q 335 1 Virus virus NN cord-007796-zggk0x2q 335 2 - - HYPH cord-007796-zggk0x2q 335 3 induced induce VBN cord-007796-zggk0x2q 335 4 exacerbations exacerbation NNS cord-007796-zggk0x2q 335 5 of of IN cord-007796-zggk0x2q 335 6 asthma asthma NN cord-007796-zggk0x2q 335 7 tend tend VBP cord-007796-zggk0x2q 335 8 to to TO cord-007796-zggk0x2q 335 9 be be VB cord-007796-zggk0x2q 335 10 resistant resistant JJ cord-007796-zggk0x2q 335 11 to to IN cord-007796-zggk0x2q 335 12 treatment treatment NN cord-007796-zggk0x2q 335 13 with with IN cord-007796-zggk0x2q 335 14 corticosteroids corticosteroid NNS cord-007796-zggk0x2q 335 15 and and CC cord-007796-zggk0x2q 335 16 may may MD cord-007796-zggk0x2q 335 17 require require VB cord-007796-zggk0x2q 335 18 a a DT cord-007796-zggk0x2q 335 19 different different JJ cord-007796-zggk0x2q 335 20 therapeutic therapeutic JJ cord-007796-zggk0x2q 335 21 approach approach NN cord-007796-zggk0x2q 335 22 . . . cord-007796-zggk0x2q 336 1 In in IN cord-007796-zggk0x2q 336 2 vitro vitro FW cord-007796-zggk0x2q 336 3 , , , cord-007796-zggk0x2q 336 4 blocking block VBG cord-007796-zggk0x2q 336 5 ICAM-1 ICAM-1 NNP cord-007796-zggk0x2q 336 6 has have VBZ cord-007796-zggk0x2q 336 7 been be VBN cord-007796-zggk0x2q 336 8 tried try VBN cord-007796-zggk0x2q 336 9 with with IN cord-007796-zggk0x2q 336 10 positive positive JJ cord-007796-zggk0x2q 336 11 results result NNS cord-007796-zggk0x2q 336 12 , , , cord-007796-zggk0x2q 336 13 which which WDT cord-007796-zggk0x2q 336 14 may may MD cord-007796-zggk0x2q 336 15 be be VB cord-007796-zggk0x2q 336 16 of of IN cord-007796-zggk0x2q 336 17 particular particular JJ cord-007796-zggk0x2q 336 18 relevance relevance NN cord-007796-zggk0x2q 336 19 to to IN cord-007796-zggk0x2q 336 20 rhinovirus rhinovirus NN cord-007796-zggk0x2q 336 21 infections infection NNS cord-007796-zggk0x2q 336 22 . . . cord-007796-zggk0x2q 337 1 The the DT cord-007796-zggk0x2q 337 2 possibility possibility NN cord-007796-zggk0x2q 337 3 of of IN cord-007796-zggk0x2q 337 4 other other JJ cord-007796-zggk0x2q 337 5 immunomodulating immunomodulating JJ cord-007796-zggk0x2q 337 6 drugs drug NNS cord-007796-zggk0x2q 337 7 is be VBZ cord-007796-zggk0x2q 337 8 being be VBG cord-007796-zggk0x2q 337 9 investigated investigate VBN cord-007796-zggk0x2q 337 10 and and CC cord-007796-zggk0x2q 337 11 may may MD cord-007796-zggk0x2q 337 12 be be VB cord-007796-zggk0x2q 337 13 of of IN cord-007796-zggk0x2q 337 14 significant significant JJ cord-007796-zggk0x2q 337 15 benefit benefit NN cord-007796-zggk0x2q 337 16 to to IN cord-007796-zggk0x2q 337 17 future future JJ cord-007796-zggk0x2q 337 18 asthma asthma NN cord-007796-zggk0x2q 337 19 treatment treatment NN cord-007796-zggk0x2q 337 20 . . . cord-007796-zggk0x2q 338 1 A a DT cord-007796-zggk0x2q 338 2 causal causal JJ cord-007796-zggk0x2q 338 3 relationship relationship NN cord-007796-zggk0x2q 338 4 between between IN cord-007796-zggk0x2q 338 5 viral viral JJ cord-007796-zggk0x2q 338 6 respiratory respiratory JJ cord-007796-zggk0x2q 338 7 tract tract NN cord-007796-zggk0x2q 338 8 infections infection NNS cord-007796-zggk0x2q 338 9 and and CC cord-007796-zggk0x2q 338 10 asthma asthma NN cord-007796-zggk0x2q 338 11 exacerbations exacerbation NNS cord-007796-zggk0x2q 338 12 is be VBZ cord-007796-zggk0x2q 338 13 generally generally RB cord-007796-zggk0x2q 338 14 acknowledged acknowledge VBN cord-007796-zggk0x2q 338 15 . . . cord-007796-zggk0x2q 339 1 However however RB cord-007796-zggk0x2q 339 2 , , , cord-007796-zggk0x2q 339 3 the the DT cord-007796-zggk0x2q 339 4 suggestion suggestion NN cord-007796-zggk0x2q 339 5 that that IN cord-007796-zggk0x2q 339 6 respiratory respiratory JJ cord-007796-zggk0x2q 339 7 virus virus NN cord-007796-zggk0x2q 339 8 infection infection NN cord-007796-zggk0x2q 339 9 is be VBZ cord-007796-zggk0x2q 339 10 a a DT cord-007796-zggk0x2q 339 11 causal causal JJ cord-007796-zggk0x2q 339 12 determinant determinant NN cord-007796-zggk0x2q 339 13 in in IN cord-007796-zggk0x2q 339 14 the the DT cord-007796-zggk0x2q 339 15 development development NN cord-007796-zggk0x2q 339 16 of of IN cord-007796-zggk0x2q 339 17 asthma asthma NN cord-007796-zggk0x2q 339 18 is be VBZ cord-007796-zggk0x2q 339 19 highly highly RB cord-007796-zggk0x2q 339 20 controversial controversial JJ cord-007796-zggk0x2q 339 21 . . . cord-007796-zggk0x2q 340 1 According accord VBG cord-007796-zggk0x2q 340 2 to to IN cord-007796-zggk0x2q 340 3 the the DT cord-007796-zggk0x2q 340 4 hygiene hygiene NN cord-007796-zggk0x2q 340 5 hypothesis hypothesis NN cord-007796-zggk0x2q 340 6 , , , cord-007796-zggk0x2q 340 7 viral viral JJ cord-007796-zggk0x2q 340 8 infection infection NN cord-007796-zggk0x2q 340 9 would would MD cord-007796-zggk0x2q 340 10 be be VB cord-007796-zggk0x2q 340 11 expected expect VBN cord-007796-zggk0x2q 340 12 to to TO cord-007796-zggk0x2q 340 13 have have VB cord-007796-zggk0x2q 340 14 an an DT cord-007796-zggk0x2q 340 15 inhibitory inhibitory JJ cord-007796-zggk0x2q 340 16 effect effect NN cord-007796-zggk0x2q 340 17 on on IN cord-007796-zggk0x2q 340 18 the the DT cord-007796-zggk0x2q 340 19 development development NN cord-007796-zggk0x2q 340 20 of of IN cord-007796-zggk0x2q 340 21 asthma asthma NN cord-007796-zggk0x2q 340 22 ( ( -LRB- cord-007796-zggk0x2q 340 23 an an DT cord-007796-zggk0x2q 340 24 allergy allergy NN cord-007796-zggk0x2q 340 25 ) ) -RRB- cord-007796-zggk0x2q 340 26 , , , cord-007796-zggk0x2q 340 27 and and CC cord-007796-zggk0x2q 340 28 this this DT cord-007796-zggk0x2q 340 29 is be VBZ cord-007796-zggk0x2q 340 30 supported support VBN cord-007796-zggk0x2q 340 31 by by IN cord-007796-zggk0x2q 340 32 a a DT cord-007796-zggk0x2q 340 33 study study NN cord-007796-zggk0x2q 340 34 from from IN cord-007796-zggk0x2q 340 35 Matricardi Matricardi NNP cord-007796-zggk0x2q 340 36 et et NNP cord-007796-zggk0x2q 340 37 al al NNP cord-007796-zggk0x2q 340 38 . . . cord-007796-zggk0x2q 341 1 ( ( -LRB- cord-007796-zggk0x2q 341 2 1997 1997 CD cord-007796-zggk0x2q 341 3 ) ) -RRB- cord-007796-zggk0x2q 341 4 , , , cord-007796-zggk0x2q 341 5 showing show VBG cord-007796-zggk0x2q 341 6 an an DT cord-007796-zggk0x2q 341 7 inverse inverse JJ cord-007796-zggk0x2q 341 8 relation relation NN cord-007796-zggk0x2q 341 9 between between IN cord-007796-zggk0x2q 341 10 hepatitis hepatitis NN cord-007796-zggk0x2q 341 11 A a DT cord-007796-zggk0x2q 341 12 seropositivity seropositivity NN cord-007796-zggk0x2q 341 13 and and CC cord-007796-zggk0x2q 341 14 atopy atopy NN cord-007796-zggk0x2q 341 15 among among IN cord-007796-zggk0x2q 341 16 soldiers soldier NNS cord-007796-zggk0x2q 341 17 . . . cord-007796-zggk0x2q 342 1 The the DT cord-007796-zggk0x2q 342 2 hygiene hygiene NN cord-007796-zggk0x2q 342 3 hypothesis hypothesis NN cord-007796-zggk0x2q 342 4 is be VBZ cord-007796-zggk0x2q 342 5 based base VBN cord-007796-zggk0x2q 342 6 on on IN cord-007796-zggk0x2q 342 7 the the DT cord-007796-zggk0x2q 342 8 theory theory NN cord-007796-zggk0x2q 342 9 that that IN cord-007796-zggk0x2q 342 10 the the DT cord-007796-zggk0x2q 342 11 immune immune JJ cord-007796-zggk0x2q 342 12 system system NN cord-007796-zggk0x2q 342 13 is be VBZ cord-007796-zggk0x2q 342 14 directed direct VBN cord-007796-zggk0x2q 342 15 toward toward IN cord-007796-zggk0x2q 342 16 a a DT cord-007796-zggk0x2q 342 17 more more RBR cord-007796-zggk0x2q 342 18 Th1-skewed th1-skewed JJ cord-007796-zggk0x2q 342 19 immune immune JJ cord-007796-zggk0x2q 342 20 response response NN cord-007796-zggk0x2q 342 21 with with IN cord-007796-zggk0x2q 342 22 each each DT cord-007796-zggk0x2q 342 23 viral viral JJ cord-007796-zggk0x2q 342 24 infection infection NN cord-007796-zggk0x2q 342 25 . . . cord-007796-zggk0x2q 343 1 However however RB cord-007796-zggk0x2q 343 2 , , , cord-007796-zggk0x2q 343 3 this this DT cord-007796-zggk0x2q 343 4 hypothesis hypothesis NN cord-007796-zggk0x2q 343 5 is be VBZ cord-007796-zggk0x2q 343 6 not not RB cord-007796-zggk0x2q 343 7 supported support VBN cord-007796-zggk0x2q 343 8 by by IN cord-007796-zggk0x2q 343 9 the the DT cord-007796-zggk0x2q 343 10 observation observation NN cord-007796-zggk0x2q 343 11 that that IN cord-007796-zggk0x2q 343 12 RSV RSV NNP cord-007796-zggk0x2q 343 13 infections infection NNS cord-007796-zggk0x2q 343 14 , , , cord-007796-zggk0x2q 343 15 severe severe JJ cord-007796-zggk0x2q 343 16 enough enough RB cord-007796-zggk0x2q 343 17 to to TO cord-007796-zggk0x2q 343 18 cause cause VB cord-007796-zggk0x2q 343 19 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 343 20 , , , cord-007796-zggk0x2q 343 21 are be VBP cord-007796-zggk0x2q 343 22 significantly significantly RB cord-007796-zggk0x2q 343 23 associated associate VBN cord-007796-zggk0x2q 343 24 with with IN cord-007796-zggk0x2q 343 25 a a DT cord-007796-zggk0x2q 343 26 higher high JJR cord-007796-zggk0x2q 343 27 incidence incidence NN cord-007796-zggk0x2q 343 28 of of IN cord-007796-zggk0x2q 343 29 asthma asthma NN cord-007796-zggk0x2q 343 30 up up IN cord-007796-zggk0x2q 343 31 to to IN cord-007796-zggk0x2q 343 32 the the DT cord-007796-zggk0x2q 343 33 age age NN cord-007796-zggk0x2q 343 34 of of IN cord-007796-zggk0x2q 343 35 7 7 CD cord-007796-zggk0x2q 343 36 - - SYM cord-007796-zggk0x2q 343 37 11 11 CD cord-007796-zggk0x2q 343 38 years year NNS cord-007796-zggk0x2q 344 1 ( ( -LRB- cord-007796-zggk0x2q 344 2 Stein Stein NNP cord-007796-zggk0x2q 344 3 et et NNP cord-007796-zggk0x2q 344 4 al al NNP cord-007796-zggk0x2q 344 5 . . NNP cord-007796-zggk0x2q 344 6 , , , cord-007796-zggk0x2q 344 7 1999 1999 CD cord-007796-zggk0x2q 344 8 ; ; : cord-007796-zggk0x2q 344 9 Sigurs Sigurs NNP cord-007796-zggk0x2q 344 10 et et NNP cord-007796-zggk0x2q 344 11 al al NNP cord-007796-zggk0x2q 344 12 . . NNP cord-007796-zggk0x2q 344 13 , , , cord-007796-zggk0x2q 344 14 2000 2000 CD cord-007796-zggk0x2q 344 15 ) ) -RRB- cord-007796-zggk0x2q 344 16 . . . cord-007796-zggk0x2q 345 1 These these DT cord-007796-zggk0x2q 345 2 data datum NNS cord-007796-zggk0x2q 345 3 convincingly convincingly RB cord-007796-zggk0x2q 345 4 show show VBP cord-007796-zggk0x2q 345 5 a a DT cord-007796-zggk0x2q 345 6 link link NN cord-007796-zggk0x2q 345 7 between between IN cord-007796-zggk0x2q 345 8 RSV RSV NNP cord-007796-zggk0x2q 345 9 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 345 10 and and CC cord-007796-zggk0x2q 345 11 recurrent recurrent JJ cord-007796-zggk0x2q 345 12 wheezing wheeze VBG cord-007796-zggk0x2q 345 13 in in IN cord-007796-zggk0x2q 345 14 childhood childhood NN cord-007796-zggk0x2q 345 15 . . . cord-007796-zggk0x2q 346 1 In in IN cord-007796-zggk0x2q 346 2 a a DT cord-007796-zggk0x2q 346 3 recent recent JJ cord-007796-zggk0x2q 346 4 study study NN cord-007796-zggk0x2q 346 5 , , , cord-007796-zggk0x2q 346 6 wheezing wheeze VBG cord-007796-zggk0x2q 346 7 following follow VBG cord-007796-zggk0x2q 346 8 RSV RSV NNP cord-007796-zggk0x2q 346 9 lower low JJR cord-007796-zggk0x2q 346 10 respiratory respiratory JJ cord-007796-zggk0x2q 346 11 tract tract NN cord-007796-zggk0x2q 346 12 infection infection NN cord-007796-zggk0x2q 346 13 was be VBD cord-007796-zggk0x2q 346 14 found find VBN cord-007796-zggk0x2q 346 15 to to TO cord-007796-zggk0x2q 346 16 develop develop VB cord-007796-zggk0x2q 346 17 independent independent JJ cord-007796-zggk0x2q 346 18 of of IN cord-007796-zggk0x2q 346 19 atopy atopy NN cord-007796-zggk0x2q 346 20 . . . cord-007796-zggk0x2q 347 1 It -PRON- PRP cord-007796-zggk0x2q 347 2 may may MD cord-007796-zggk0x2q 347 3 , , , cord-007796-zggk0x2q 347 4 however however RB cord-007796-zggk0x2q 347 5 , , , cord-007796-zggk0x2q 347 6 be be VB cord-007796-zggk0x2q 347 7 true true JJ cord-007796-zggk0x2q 347 8 that that IN cord-007796-zggk0x2q 347 9 the the DT cord-007796-zggk0x2q 347 10 transmission transmission NN cord-007796-zggk0x2q 347 11 route route NN cord-007796-zggk0x2q 347 12 , , , cord-007796-zggk0x2q 347 13 the the DT cord-007796-zggk0x2q 347 14 organs organ NNS cord-007796-zggk0x2q 347 15 involved involve VBN cord-007796-zggk0x2q 347 16 , , , cord-007796-zggk0x2q 347 17 and and CC cord-007796-zggk0x2q 347 18 exposure exposure NN cord-007796-zggk0x2q 347 19 to to IN cord-007796-zggk0x2q 347 20 microbial microbial JJ cord-007796-zggk0x2q 347 21 products product NNS cord-007796-zggk0x2q 347 22 may may MD cord-007796-zggk0x2q 347 23 be be VB cord-007796-zggk0x2q 347 24 important important JJ cord-007796-zggk0x2q 347 25 in in IN cord-007796-zggk0x2q 347 26 determining determine VBG cord-007796-zggk0x2q 347 27 the the DT cord-007796-zggk0x2q 347 28 final final JJ cord-007796-zggk0x2q 347 29 effect effect NN cord-007796-zggk0x2q 347 30 of of IN cord-007796-zggk0x2q 347 31 a a DT cord-007796-zggk0x2q 347 32 virus virus NN cord-007796-zggk0x2q 347 33 infection infection NN cord-007796-zggk0x2q 347 34 on on IN cord-007796-zggk0x2q 347 35 the the DT cord-007796-zggk0x2q 347 36 development development NN cord-007796-zggk0x2q 347 37 of of IN cord-007796-zggk0x2q 347 38 asthma asthma NN cord-007796-zggk0x2q 347 39 and and CC cord-007796-zggk0x2q 347 40 allergy allergy NN cord-007796-zggk0x2q 347 41 ( ( -LRB- cord-007796-zggk0x2q 347 42 Gern Gern NNP cord-007796-zggk0x2q 347 43 and and CC cord-007796-zggk0x2q 347 44 Busse Busse NNP cord-007796-zggk0x2q 347 45 , , , cord-007796-zggk0x2q 347 46 2002 2002 CD cord-007796-zggk0x2q 347 47 ) ) -RRB- cord-007796-zggk0x2q 347 48 . . . cord-007796-zggk0x2q 348 1 The the DT cord-007796-zggk0x2q 348 2 link link NN cord-007796-zggk0x2q 348 3 between between IN cord-007796-zggk0x2q 348 4 RSV RSV NNP cord-007796-zggk0x2q 348 5 infection infection NN cord-007796-zggk0x2q 348 6 and and CC cord-007796-zggk0x2q 348 7 atopy atopy NN cord-007796-zggk0x2q 348 8 is be VBZ cord-007796-zggk0x2q 348 9 even even RB cord-007796-zggk0x2q 348 10 less less RBR cord-007796-zggk0x2q 348 11 clear clear JJ cord-007796-zggk0x2q 348 12 than than IN cord-007796-zggk0x2q 348 13 the the DT cord-007796-zggk0x2q 348 14 one one CD cord-007796-zggk0x2q 348 15 with with IN cord-007796-zggk0x2q 348 16 recurrent recurrent JJ cord-007796-zggk0x2q 348 17 wheezing wheezing NN cord-007796-zggk0x2q 348 18 and and CC cord-007796-zggk0x2q 348 19 asthma asthma NN cord-007796-zggk0x2q 348 20 , , , cord-007796-zggk0x2q 348 21 at at IN cord-007796-zggk0x2q 348 22 least least JJS cord-007796-zggk0x2q 348 23 in in IN cord-007796-zggk0x2q 348 24 humans human NNS cord-007796-zggk0x2q 348 25 . . . cord-007796-zggk0x2q 349 1 Animal animal NN cord-007796-zggk0x2q 349 2 studies study NNS cord-007796-zggk0x2q 349 3 have have VBP cord-007796-zggk0x2q 349 4 yielded yield VBN cord-007796-zggk0x2q 349 5 conflicting conflicting JJ cord-007796-zggk0x2q 349 6 results result NNS cord-007796-zggk0x2q 349 7 . . . cord-007796-zggk0x2q 350 1 One one CD cord-007796-zggk0x2q 350 2 group group NN cord-007796-zggk0x2q 350 3 found find VBD cord-007796-zggk0x2q 350 4 that that IN cord-007796-zggk0x2q 350 5 RSV RSV NNP cord-007796-zggk0x2q 350 6 infection infection NN cord-007796-zggk0x2q 350 7 in in IN cord-007796-zggk0x2q 350 8 mice mice NN cord-007796-zggk0x2q 350 9 enhances enhance VBZ cord-007796-zggk0x2q 350 10 subsequent subsequent JJ cord-007796-zggk0x2q 350 11 allergic allergic JJ cord-007796-zggk0x2q 350 12 inflammation inflammation NN cord-007796-zggk0x2q 350 13 ( ( -LRB- cord-007796-zggk0x2q 350 14 Schwarze Schwarze NNP cord-007796-zggk0x2q 350 15 et et NNP cord-007796-zggk0x2q 350 16 al al NNP cord-007796-zggk0x2q 350 17 . . NNP cord-007796-zggk0x2q 350 18 , , , cord-007796-zggk0x2q 350 19 1997 1997 CD cord-007796-zggk0x2q 350 20 ) ) -RRB- cord-007796-zggk0x2q 350 21 , , , cord-007796-zggk0x2q 350 22 while while IN cord-007796-zggk0x2q 350 23 others other NNS cord-007796-zggk0x2q 350 24 reported report VBD cord-007796-zggk0x2q 350 25 a a DT cord-007796-zggk0x2q 350 26 decrease decrease NN cord-007796-zggk0x2q 350 27 in in IN cord-007796-zggk0x2q 350 28 allergic allergic JJ cord-007796-zggk0x2q 350 29 sensitization sensitization NN cord-007796-zggk0x2q 350 30 and and CC cord-007796-zggk0x2q 350 31 BHR BHR NNP cord-007796-zggk0x2q 350 32 after after IN cord-007796-zggk0x2q 350 33 RSV RSV NNP cord-007796-zggk0x2q 350 34 infection infection NN cord-007796-zggk0x2q 350 35 ( ( -LRB- cord-007796-zggk0x2q 350 36 Peebles Peebles NNP cord-007796-zggk0x2q 350 37 et et NNP cord-007796-zggk0x2q 350 38 al al NNP cord-007796-zggk0x2q 350 39 . . NNP cord-007796-zggk0x2q 350 40 , , , cord-007796-zggk0x2q 350 41 2001 2001 CD cord-007796-zggk0x2q 350 42 ) ) -RRB- cord-007796-zggk0x2q 350 43 . . . cord-007796-zggk0x2q 351 1 No no DT cord-007796-zggk0x2q 351 2 proof proof NN cord-007796-zggk0x2q 351 3 exists exist VBZ cord-007796-zggk0x2q 351 4 that that IN cord-007796-zggk0x2q 351 5 severe severe JJ cord-007796-zggk0x2q 351 6 RSV RSV NNP cord-007796-zggk0x2q 351 7 infections infection NNS cord-007796-zggk0x2q 351 8 are be VBP cord-007796-zggk0x2q 351 9 associated associate VBN cord-007796-zggk0x2q 351 10 with with IN cord-007796-zggk0x2q 351 11 atopy atopy NN cord-007796-zggk0x2q 351 12 that that WDT cord-007796-zggk0x2q 351 13 persists persist VBZ cord-007796-zggk0x2q 351 14 into into IN cord-007796-zggk0x2q 351 15 adulthood adulthood NN cord-007796-zggk0x2q 351 16 ( ( -LRB- cord-007796-zggk0x2q 351 17 Peebles Peebles NNP cord-007796-zggk0x2q 351 18 , , , cord-007796-zggk0x2q 351 19 2004 2004 CD cord-007796-zggk0x2q 351 20 ) ) -RRB- cord-007796-zggk0x2q 351 21 . . . cord-007796-zggk0x2q 352 1 A a DT cord-007796-zggk0x2q 352 2 key key JJ cord-007796-zggk0x2q 352 3 question question NN cord-007796-zggk0x2q 352 4 is be VBZ cord-007796-zggk0x2q 352 5 whether whether IN cord-007796-zggk0x2q 352 6 the the DT cord-007796-zggk0x2q 352 7 association association NN cord-007796-zggk0x2q 352 8 with with IN cord-007796-zggk0x2q 352 9 the the DT cord-007796-zggk0x2q 352 10 development development NN cord-007796-zggk0x2q 352 11 of of IN cord-007796-zggk0x2q 352 12 asthma asthma NN cord-007796-zggk0x2q 352 13 is be VBZ cord-007796-zggk0x2q 352 14 merely merely RB cord-007796-zggk0x2q 352 15 an an DT cord-007796-zggk0x2q 352 16 expression expression NN cord-007796-zggk0x2q 352 17 of of IN cord-007796-zggk0x2q 352 18 increased increase VBN cord-007796-zggk0x2q 352 19 susceptibility susceptibility NN cord-007796-zggk0x2q 352 20 to to IN cord-007796-zggk0x2q 352 21 both both CC cord-007796-zggk0x2q 352 22 asthma asthma NN cord-007796-zggk0x2q 352 23 and and CC cord-007796-zggk0x2q 352 24 RSV RSV NNP cord-007796-zggk0x2q 352 25 - - HYPH cord-007796-zggk0x2q 352 26 induced induce VBN cord-007796-zggk0x2q 352 27 lower low JJR cord-007796-zggk0x2q 352 28 respiratory respiratory JJ cord-007796-zggk0x2q 352 29 tract tract NN cord-007796-zggk0x2q 352 30 infections infection NNS cord-007796-zggk0x2q 352 31 or or CC cord-007796-zggk0x2q 352 32 whether whether IN cord-007796-zggk0x2q 352 33 true true JJ cord-007796-zggk0x2q 352 34 causality causality NN cord-007796-zggk0x2q 352 35 is be VBZ cord-007796-zggk0x2q 352 36 involved involve VBN cord-007796-zggk0x2q 352 37 . . . cord-007796-zggk0x2q 353 1 The the DT cord-007796-zggk0x2q 353 2 prevailing prevail VBG cord-007796-zggk0x2q 353 3 theory theory NN cord-007796-zggk0x2q 353 4 on on IN cord-007796-zggk0x2q 353 5 this this DT cord-007796-zggk0x2q 353 6 subject subject NN cord-007796-zggk0x2q 353 7 involves involve VBZ cord-007796-zggk0x2q 353 8 maturation maturation NN cord-007796-zggk0x2q 353 9 effects effect NNS cord-007796-zggk0x2q 353 10 of of IN cord-007796-zggk0x2q 353 11 the the DT cord-007796-zggk0x2q 353 12 Th1 th1 CD cord-007796-zggk0x2q 353 13 / / SYM cord-007796-zggk0x2q 353 14 Th2-balance th2-balance NN cord-007796-zggk0x2q 353 15 . . . cord-007796-zggk0x2q 354 1 The the DT cord-007796-zggk0x2q 354 2 system system NN cord-007796-zggk0x2q 354 3 shifts shift VBZ cord-007796-zggk0x2q 354 4 from from IN cord-007796-zggk0x2q 354 5 a a DT cord-007796-zggk0x2q 354 6 Th2-polarization Th2-polarization NNP cord-007796-zggk0x2q 354 7 in in IN cord-007796-zggk0x2q 354 8 fetal fetal JJ cord-007796-zggk0x2q 354 9 life life NN cord-007796-zggk0x2q 354 10 , , , cord-007796-zggk0x2q 354 11 which which WDT cord-007796-zggk0x2q 354 12 is be VBZ cord-007796-zggk0x2q 354 13 an an DT cord-007796-zggk0x2q 354 14 optimal optimal JJ cord-007796-zggk0x2q 354 15 environment environment NN cord-007796-zggk0x2q 354 16 for for IN cord-007796-zggk0x2q 354 17 the the DT cord-007796-zggk0x2q 354 18 placenta placenta NN cord-007796-zggk0x2q 354 19 , , , cord-007796-zggk0x2q 354 20 to to IN cord-007796-zggk0x2q 354 21 a a DT cord-007796-zggk0x2q 354 22 more more RBR cord-007796-zggk0x2q 354 23 balanced balanced JJ cord-007796-zggk0x2q 354 24 Th1 th1 NN cord-007796-zggk0x2q 354 25 / / SYM cord-007796-zggk0x2q 354 26 Th2-phenotype th2-phenotype CD cord-007796-zggk0x2q 354 27 in in IN cord-007796-zggk0x2q 354 28 adulthood adulthood NN cord-007796-zggk0x2q 354 29 . . . cord-007796-zggk0x2q 355 1 Most Most JJS cord-007796-zggk0x2q 355 2 viruses virus NNS cord-007796-zggk0x2q 355 3 are be VBP cord-007796-zggk0x2q 355 4 known know VBN cord-007796-zggk0x2q 355 5 to to TO cord-007796-zggk0x2q 355 6 induce induce VB cord-007796-zggk0x2q 355 7 a a DT cord-007796-zggk0x2q 355 8 Th1 th1 CD cord-007796-zggk0x2q 355 9 cytokine cytokine NN cord-007796-zggk0x2q 355 10 response response NN cord-007796-zggk0x2q 355 11 ( ( -LRB- cord-007796-zggk0x2q 355 12 IFN- IFN- NNP cord-007796-zggk0x2q 355 13 ␥ ␥ NNP cord-007796-zggk0x2q 355 14 ) ) -RRB- cord-007796-zggk0x2q 355 15 . . . cord-007796-zggk0x2q 356 1 This this DT cord-007796-zggk0x2q 356 2 theory theory NN cord-007796-zggk0x2q 356 3 states state VBZ cord-007796-zggk0x2q 356 4 that that IN cord-007796-zggk0x2q 356 5 when when WRB cord-007796-zggk0x2q 356 6 infections infection NNS cord-007796-zggk0x2q 356 7 occur occur VBP cord-007796-zggk0x2q 356 8 early early RB cord-007796-zggk0x2q 356 9 in in IN cord-007796-zggk0x2q 356 10 infancy infancy NN cord-007796-zggk0x2q 356 11 , , , cord-007796-zggk0x2q 356 12 there there EX cord-007796-zggk0x2q 356 13 is be VBZ cord-007796-zggk0x2q 356 14 a a DT cord-007796-zggk0x2q 356 15 reduced reduce VBN cord-007796-zggk0x2q 356 16 ability ability NN cord-007796-zggk0x2q 356 17 to to TO cord-007796-zggk0x2q 356 18 react react VB cord-007796-zggk0x2q 356 19 with with IN cord-007796-zggk0x2q 356 20 an an DT cord-007796-zggk0x2q 356 21 appropriate appropriate JJ cord-007796-zggk0x2q 356 22 antiviral antiviral JJ cord-007796-zggk0x2q 356 23 Th1-response Th1-response NNP cord-007796-zggk0x2q 356 24 . . . cord-007796-zggk0x2q 357 1 Low low JJ cord-007796-zggk0x2q 357 2 IFN- IFN- NNP cord-007796-zggk0x2q 357 3 ␥ ␥ CD cord-007796-zggk0x2q 357 4 production production NN cord-007796-zggk0x2q 357 5 may may MD cord-007796-zggk0x2q 357 6 result result VB cord-007796-zggk0x2q 357 7 in in IN cord-007796-zggk0x2q 357 8 spread spread NN cord-007796-zggk0x2q 357 9 of of IN cord-007796-zggk0x2q 357 10 the the DT cord-007796-zggk0x2q 357 11 virus virus NN cord-007796-zggk0x2q 357 12 to to IN cord-007796-zggk0x2q 357 13 the the DT cord-007796-zggk0x2q 357 14 lower low JJR cord-007796-zggk0x2q 357 15 respiratory respiratory JJ cord-007796-zggk0x2q 357 16 tract tract NN cord-007796-zggk0x2q 357 17 . . . cord-007796-zggk0x2q 358 1 This this DT cord-007796-zggk0x2q 358 2 is be VBZ cord-007796-zggk0x2q 358 3 in in IN cord-007796-zggk0x2q 358 4 agreement agreement NN cord-007796-zggk0x2q 358 5 with with IN cord-007796-zggk0x2q 358 6 findings finding NNS cord-007796-zggk0x2q 358 7 that that IN cord-007796-zggk0x2q 358 8 in in IN cord-007796-zggk0x2q 358 9 children child NNS cord-007796-zggk0x2q 358 10 with with IN cord-007796-zggk0x2q 358 11 severe severe JJ cord-007796-zggk0x2q 358 12 RSV RSV NNP cord-007796-zggk0x2q 358 13 lower low JJR cord-007796-zggk0x2q 358 14 respiratory respiratory JJ cord-007796-zggk0x2q 358 15 tract tract NN cord-007796-zggk0x2q 358 16 infections infection NNS cord-007796-zggk0x2q 358 17 , , , cord-007796-zggk0x2q 358 18 lower low JJR cord-007796-zggk0x2q 358 19 amounts amount NNS cord-007796-zggk0x2q 358 20 of of IN cord-007796-zggk0x2q 358 21 IFN- IFN- NNP cord-007796-zggk0x2q 358 22 ␥ ␥ NNPS cord-007796-zggk0x2q 358 23 are be VBP cord-007796-zggk0x2q 358 24 produced produce VBN cord-007796-zggk0x2q 358 25 . . . cord-007796-zggk0x2q 359 1 The the DT cord-007796-zggk0x2q 359 2 dynamics dynamic NNS cord-007796-zggk0x2q 359 3 of of IN cord-007796-zggk0x2q 359 4 this this DT cord-007796-zggk0x2q 359 5 shift shift NN cord-007796-zggk0x2q 359 6 toward toward IN cord-007796-zggk0x2q 359 7 a a DT cord-007796-zggk0x2q 359 8 more more RBR cord-007796-zggk0x2q 359 9 balanced balanced JJ cord-007796-zggk0x2q 359 10 Th1 th1 NN cord-007796-zggk0x2q 359 11 / / SYM cord-007796-zggk0x2q 359 12 Th2 th2 CD cord-007796-zggk0x2q 359 13 immune immune JJ cord-007796-zggk0x2q 359 14 response response NN cord-007796-zggk0x2q 359 15 may may MD cord-007796-zggk0x2q 359 16 differ differ VB cord-007796-zggk0x2q 359 17 between between IN cord-007796-zggk0x2q 359 18 individuals individual NNS cord-007796-zggk0x2q 359 19 . . . cord-007796-zggk0x2q 360 1 Both both DT cord-007796-zggk0x2q 360 2 environmental environmental JJ cord-007796-zggk0x2q 360 3 factors factor NNS cord-007796-zggk0x2q 360 4 and and CC cord-007796-zggk0x2q 360 5 genetic genetic JJ cord-007796-zggk0x2q 360 6 make make NN cord-007796-zggk0x2q 360 7 - - HYPH cord-007796-zggk0x2q 360 8 up up NN cord-007796-zggk0x2q 360 9 may may MD cord-007796-zggk0x2q 360 10 contribute contribute VB cord-007796-zggk0x2q 360 11 to to IN cord-007796-zggk0x2q 360 12 a a DT cord-007796-zggk0x2q 360 13 slower slow JJR cord-007796-zggk0x2q 360 14 maturation maturation NN cord-007796-zggk0x2q 360 15 of of IN cord-007796-zggk0x2q 360 16 Th1 th1 CD cord-007796-zggk0x2q 360 17 competence competence NN cord-007796-zggk0x2q 360 18 in in IN cord-007796-zggk0x2q 360 19 some some DT cord-007796-zggk0x2q 360 20 individuals individual NNS cord-007796-zggk0x2q 360 21 . . . cord-007796-zggk0x2q 361 1 Respiratory respiratory JJ cord-007796-zggk0x2q 361 2 virus virus NN cord-007796-zggk0x2q 361 3 infections infection NNS cord-007796-zggk0x2q 361 4 in in IN cord-007796-zggk0x2q 361 5 infancy infancy NN cord-007796-zggk0x2q 361 6 and and CC cord-007796-zggk0x2q 361 7 an an DT cord-007796-zggk0x2q 361 8 atopic atopic JJ cord-007796-zggk0x2q 361 9 sensitization sensitization NN cord-007796-zggk0x2q 361 10 to to IN cord-007796-zggk0x2q 361 11 aero aero NNS cord-007796-zggk0x2q 361 12 - - HYPH cord-007796-zggk0x2q 361 13 allergens allergen NNS cord-007796-zggk0x2q 361 14 , , , cord-007796-zggk0x2q 361 15 both both DT cord-007796-zggk0x2q 361 16 of of IN cord-007796-zggk0x2q 361 17 which which WDT cord-007796-zggk0x2q 361 18 are be VBP cord-007796-zggk0x2q 361 19 related relate VBN cord-007796-zggk0x2q 361 20 to to IN cord-007796-zggk0x2q 361 21 Th2-skewed th2-skewed JJ cord-007796-zggk0x2q 361 22 responses response NNS cord-007796-zggk0x2q 361 23 and and CC cord-007796-zggk0x2q 361 24 intermittent intermittent JJ cord-007796-zggk0x2q 361 25 wheeze wheeze NN cord-007796-zggk0x2q 361 26 , , , cord-007796-zggk0x2q 361 27 may may MD cord-007796-zggk0x2q 361 28 than than IN cord-007796-zggk0x2q 361 29 synergistically synergistically RB cord-007796-zggk0x2q 361 30 result result VB cord-007796-zggk0x2q 361 31 in in IN cord-007796-zggk0x2q 361 32 persistent persistent JJ cord-007796-zggk0x2q 361 33 wheeze wheeze NN cord-007796-zggk0x2q 361 34 ( ( -LRB- cord-007796-zggk0x2q 361 35 Holt Holt NNP cord-007796-zggk0x2q 361 36 and and CC cord-007796-zggk0x2q 361 37 Sly Sly NNP cord-007796-zggk0x2q 361 38 , , , cord-007796-zggk0x2q 361 39 2002 2002 CD cord-007796-zggk0x2q 361 40 ) ) -RRB- cord-007796-zggk0x2q 361 41 . . . cord-007796-zggk0x2q 362 1 It -PRON- PRP cord-007796-zggk0x2q 362 2 is be VBZ cord-007796-zggk0x2q 362 3 likely likely JJ cord-007796-zggk0x2q 362 4 that that IN cord-007796-zggk0x2q 362 5 more more JJR cord-007796-zggk0x2q 362 6 links link NNS cord-007796-zggk0x2q 362 7 between between IN cord-007796-zggk0x2q 362 8 atopic atopic JJ cord-007796-zggk0x2q 362 9 sensitization sensitization NN cord-007796-zggk0x2q 362 10 and and CC cord-007796-zggk0x2q 362 11 respiratory respiratory JJ cord-007796-zggk0x2q 362 12 infections infection NNS cord-007796-zggk0x2q 362 13 exist exist VBP cord-007796-zggk0x2q 362 14 , , , cord-007796-zggk0x2q 362 15 while while IN cord-007796-zggk0x2q 362 16 preventive preventive JJ cord-007796-zggk0x2q 362 17 RSV RSV NNP cord-007796-zggk0x2q 362 18 - - HYPH cord-007796-zggk0x2q 362 19 IVIG IVIG NNP cord-007796-zggk0x2q 362 20 treatment treatment NN cord-007796-zggk0x2q 362 21 of of IN cord-007796-zggk0x2q 362 22 children child NNS cord-007796-zggk0x2q 362 23 results result VBZ cord-007796-zggk0x2q 362 24 in in IN cord-007796-zggk0x2q 362 25 a a DT cord-007796-zggk0x2q 362 26 decreased decrease VBN cord-007796-zggk0x2q 362 27 sensitization sensitization NN cord-007796-zggk0x2q 362 28 to to IN cord-007796-zggk0x2q 362 29 aeroallergens aeroallergen NNS cord-007796-zggk0x2q 362 30 as as RB cord-007796-zggk0x2q 362 31 well well RB cord-007796-zggk0x2q 362 32 . . . cord-007796-zggk0x2q 363 1 RSV RSV NNP cord-007796-zggk0x2q 363 2 - - HYPH cord-007796-zggk0x2q 363 3 prophylaxis prophylaxis NN cord-007796-zggk0x2q 363 4 may may MD cord-007796-zggk0x2q 363 5 therefore therefore RB cord-007796-zggk0x2q 363 6 have have VB cord-007796-zggk0x2q 363 7 a a DT cord-007796-zggk0x2q 363 8 long long JJ cord-007796-zggk0x2q 363 9 - - HYPH cord-007796-zggk0x2q 363 10 term term NN cord-007796-zggk0x2q 363 11 benefit benefit NN cord-007796-zggk0x2q 363 12 in in IN cord-007796-zggk0x2q 363 13 the the DT cord-007796-zggk0x2q 363 14 development development NN cord-007796-zggk0x2q 363 15 of of IN cord-007796-zggk0x2q 363 16 persistent persistent JJ cord-007796-zggk0x2q 363 17 wheeze wheeze NN cord-007796-zggk0x2q 363 18 ( ( -LRB- cord-007796-zggk0x2q 363 19 Piedimonte Piedimonte NNP cord-007796-zggk0x2q 363 20 and and CC cord-007796-zggk0x2q 363 21 Simoes Simoes NNP cord-007796-zggk0x2q 363 22 , , , cord-007796-zggk0x2q 363 23 2002 2002 CD cord-007796-zggk0x2q 363 24 ; ; : cord-007796-zggk0x2q 364 1 Wenzel Wenzel NNP cord-007796-zggk0x2q 364 2 et et NNP cord-007796-zggk0x2q 364 3 al al NNP cord-007796-zggk0x2q 364 4 . . NNP cord-007796-zggk0x2q 364 5 , , , cord-007796-zggk0x2q 364 6 2002 2002 CD cord-007796-zggk0x2q 364 7 ) ) -RRB- cord-007796-zggk0x2q 364 8 . . . cord-007796-zggk0x2q 365 1 Another another DT cord-007796-zggk0x2q 365 2 theory theory NN cord-007796-zggk0x2q 365 3 linking link VBG cord-007796-zggk0x2q 365 4 viral viral JJ cord-007796-zggk0x2q 365 5 infections infection NNS cord-007796-zggk0x2q 365 6 in in IN cord-007796-zggk0x2q 365 7 childhood childhood NN cord-007796-zggk0x2q 365 8 to to IN cord-007796-zggk0x2q 365 9 the the DT cord-007796-zggk0x2q 365 10 development development NN cord-007796-zggk0x2q 365 11 of of IN cord-007796-zggk0x2q 365 12 asthma asthma NN cord-007796-zggk0x2q 365 13 involves involve VBZ cord-007796-zggk0x2q 365 14 the the DT cord-007796-zggk0x2q 365 15 pathologic pathologic JJ cord-007796-zggk0x2q 365 16 effects effect NNS cord-007796-zggk0x2q 365 17 of of IN cord-007796-zggk0x2q 365 18 viral viral JJ cord-007796-zggk0x2q 365 19 lower low JJR cord-007796-zggk0x2q 365 20 respiratory respiratory JJ cord-007796-zggk0x2q 365 21 tract tract NN cord-007796-zggk0x2q 365 22 infections infection NNS cord-007796-zggk0x2q 365 23 on on IN cord-007796-zggk0x2q 365 24 airway airway NN cord-007796-zggk0x2q 365 25 physiology physiology NN cord-007796-zggk0x2q 365 26 . . . cord-007796-zggk0x2q 366 1 Wall wall NN cord-007796-zggk0x2q 366 2 thickening thicken VBG cord-007796-zggk0x2q 366 3 with with IN cord-007796-zggk0x2q 366 4 consequent consequent JJ cord-007796-zggk0x2q 366 5 increased increase VBN cord-007796-zggk0x2q 366 6 resistance resistance NN cord-007796-zggk0x2q 366 7 may may MD cord-007796-zggk0x2q 366 8 predispose predispose VB cord-007796-zggk0x2q 366 9 the the DT cord-007796-zggk0x2q 366 10 airway airway NN cord-007796-zggk0x2q 366 11 to to IN cord-007796-zggk0x2q 366 12 more more JJR cord-007796-zggk0x2q 366 13 infections infection NNS cord-007796-zggk0x2q 366 14 and and CC cord-007796-zggk0x2q 366 15 thus thus RB cord-007796-zggk0x2q 366 16 influence influence VBP cord-007796-zggk0x2q 366 17 bronchial bronchial JJ cord-007796-zggk0x2q 366 18 hyperreactivity hyperreactivity NN cord-007796-zggk0x2q 367 1 ( ( -LRB- cord-007796-zggk0x2q 367 2 Bardin Bardin NNP cord-007796-zggk0x2q 367 3 et et NNP cord-007796-zggk0x2q 367 4 al al NNP cord-007796-zggk0x2q 367 5 . . NNP cord-007796-zggk0x2q 367 6 , , , cord-007796-zggk0x2q 367 7 1992 1992 CD cord-007796-zggk0x2q 367 8 ) ) -RRB- cord-007796-zggk0x2q 367 9 . . . cord-007796-zggk0x2q 368 1 However however RB cord-007796-zggk0x2q 368 2 , , , cord-007796-zggk0x2q 368 3 it -PRON- PRP cord-007796-zggk0x2q 368 4 may may MD cord-007796-zggk0x2q 368 5 also also RB cord-007796-zggk0x2q 368 6 be be VB cord-007796-zggk0x2q 368 7 true true JJ cord-007796-zggk0x2q 368 8 that that IN cord-007796-zggk0x2q 368 9 small small JJ cord-007796-zggk0x2q 368 10 airways airway NNS cord-007796-zggk0x2q 368 11 predispose predispose VBP cord-007796-zggk0x2q 368 12 to to IN cord-007796-zggk0x2q 368 13 both both CC cord-007796-zggk0x2q 368 14 asthma asthma NN cord-007796-zggk0x2q 368 15 and and CC cord-007796-zggk0x2q 368 16 airway airway NN cord-007796-zggk0x2q 368 17 symptoms symptom NNS cord-007796-zggk0x2q 368 18 from from IN cord-007796-zggk0x2q 368 19 viral viral JJ cord-007796-zggk0x2q 368 20 infections infection NNS cord-007796-zggk0x2q 368 21 . . . cord-007796-zggk0x2q 369 1 Remodeling remodeling NN cord-007796-zggk0x2q 369 2 of of IN cord-007796-zggk0x2q 369 3 the the DT cord-007796-zggk0x2q 369 4 submucosal submucosal NNP cord-007796-zggk0x2q 369 5 neural neural JJ cord-007796-zggk0x2q 369 6 networks network NNS cord-007796-zggk0x2q 369 7 by by IN cord-007796-zggk0x2q 369 8 RSV RSV NNP cord-007796-zggk0x2q 369 9 , , , cord-007796-zggk0x2q 369 10 as as IN cord-007796-zggk0x2q 369 11 observed observe VBN cord-007796-zggk0x2q 369 12 by by IN cord-007796-zggk0x2q 369 13 Piedimonte Piedimonte NNP cord-007796-zggk0x2q 369 14 et et FW cord-007796-zggk0x2q 369 15 al al NNP cord-007796-zggk0x2q 369 16 . . NNP cord-007796-zggk0x2q 369 17 , , , cord-007796-zggk0x2q 369 18 is be VBZ cord-007796-zggk0x2q 369 19 also also RB cord-007796-zggk0x2q 369 20 proposed propose VBN cord-007796-zggk0x2q 369 21 to to TO cord-007796-zggk0x2q 369 22 result result VB cord-007796-zggk0x2q 369 23 in in IN cord-007796-zggk0x2q 369 24 increased increase VBN cord-007796-zggk0x2q 369 25 responsiveness responsiveness NN cord-007796-zggk0x2q 369 26 to to IN cord-007796-zggk0x2q 369 27 airway airway NN cord-007796-zggk0x2q 369 28 irritants irritant NNS cord-007796-zggk0x2q 369 29 ( ( -LRB- cord-007796-zggk0x2q 369 30 Piedimonte Piedimonte NNP cord-007796-zggk0x2q 369 31 , , , cord-007796-zggk0x2q 369 32 2002 2002 CD cord-007796-zggk0x2q 369 33 ) ) -RRB- cord-007796-zggk0x2q 369 34 . . . cord-007796-zggk0x2q 370 1 Walter Walter NNP cord-007796-zggk0x2q 370 2 et et NNP cord-007796-zggk0x2q 370 3 al al NNP cord-007796-zggk0x2q 370 4 . . . cord-007796-zggk0x2q 371 1 ( ( -LRB- cord-007796-zggk0x2q 371 2 2002 2002 CD cord-007796-zggk0x2q 371 3 ) ) -RRB- cord-007796-zggk0x2q 371 4 have have VBP cord-007796-zggk0x2q 371 5 proposed propose VBN cord-007796-zggk0x2q 371 6 that that IN cord-007796-zggk0x2q 371 7 paramyxoviral paramyxoviral JJ cord-007796-zggk0x2q 371 8 infection infection NN cord-007796-zggk0x2q 371 9 has have VBZ cord-007796-zggk0x2q 371 10 the the DT cord-007796-zggk0x2q 371 11 ability ability NN cord-007796-zggk0x2q 371 12 not not RB cord-007796-zggk0x2q 371 13 only only RB cord-007796-zggk0x2q 371 14 to to TO cord-007796-zggk0x2q 371 15 induce induce VB cord-007796-zggk0x2q 371 16 acute acute JJ cord-007796-zggk0x2q 371 17 hyperresponsiveness hyperresponsiveness NN cord-007796-zggk0x2q 371 18 , , , cord-007796-zggk0x2q 371 19 but but CC cord-007796-zggk0x2q 371 20 also also RB cord-007796-zggk0x2q 371 21 to to TO cord-007796-zggk0x2q 371 22 result result VB cord-007796-zggk0x2q 371 23 in in IN cord-007796-zggk0x2q 371 24 long long RB cord-007796-zggk0x2q 371 25 - - HYPH cord-007796-zggk0x2q 371 26 lasting last VBG cord-007796-zggk0x2q 371 27 changes change NNS cord-007796-zggk0x2q 371 28 in in IN cord-007796-zggk0x2q 371 29 airway airway NN cord-007796-zggk0x2q 371 30 behavior behavior NN cord-007796-zggk0x2q 371 31 . . . cord-007796-zggk0x2q 372 1 From from IN cord-007796-zggk0x2q 372 2 mouse mouse NN cord-007796-zggk0x2q 372 3 - - HYPH cord-007796-zggk0x2q 372 4 studies study NNS cord-007796-zggk0x2q 372 5 with with IN cord-007796-zggk0x2q 372 6 a a DT cord-007796-zggk0x2q 372 7 PIV PIV NNP cord-007796-zggk0x2q 372 8 ( ( -LRB- cord-007796-zggk0x2q 372 9 SeV SeV NNP cord-007796-zggk0x2q 372 10 ) ) -RRB- cord-007796-zggk0x2q 372 11 , , , cord-007796-zggk0x2q 372 12 it -PRON- PRP cord-007796-zggk0x2q 372 13 has have VBZ cord-007796-zggk0x2q 372 14 been be VBN cord-007796-zggk0x2q 372 15 concluded conclude VBN cord-007796-zggk0x2q 372 16 that that IN cord-007796-zggk0x2q 372 17 viruses virus NNS cord-007796-zggk0x2q 372 18 cause cause VBP cord-007796-zggk0x2q 372 19 long long JJ cord-007796-zggk0x2q 372 20 - - HYPH cord-007796-zggk0x2q 372 21 term term NN cord-007796-zggk0x2q 372 22 effects effect NNS cord-007796-zggk0x2q 372 23 in in IN cord-007796-zggk0x2q 372 24 epithelial epithelial JJ cord-007796-zggk0x2q 372 25 cells cell NNS cord-007796-zggk0x2q 372 26 , , , cord-007796-zggk0x2q 372 27 associated associate VBN cord-007796-zggk0x2q 372 28 with with IN cord-007796-zggk0x2q 372 29 airway airway NN cord-007796-zggk0x2q 372 30 reactivity reactivity NN cord-007796-zggk0x2q 372 31 and and CC cord-007796-zggk0x2q 372 32 goblet goblet NN cord-007796-zggk0x2q 372 33 cell cell NN cord-007796-zggk0x2q 372 34 hyperplasia hyperplasia NN cord-007796-zggk0x2q 372 35 . . . cord-007796-zggk0x2q 373 1 Long long JJ cord-007796-zggk0x2q 373 2 - - HYPH cord-007796-zggk0x2q 373 3 term term NN cord-007796-zggk0x2q 373 4 effects effect NNS cord-007796-zggk0x2q 373 5 are be VBP cord-007796-zggk0x2q 373 6 induced induce VBN cord-007796-zggk0x2q 373 7 by by IN cord-007796-zggk0x2q 373 8 the the DT cord-007796-zggk0x2q 373 9 virus virus NN cord-007796-zggk0x2q 373 10 in in IN cord-007796-zggk0x2q 373 11 the the DT cord-007796-zggk0x2q 373 12 acute acute JJ cord-007796-zggk0x2q 373 13 phase phase NN cord-007796-zggk0x2q 373 14 , , , cord-007796-zggk0x2q 373 15 and and CC cord-007796-zggk0x2q 373 16 later later RB cord-007796-zggk0x2q 373 17 on on RB cord-007796-zggk0x2q 373 18 , , , cord-007796-zggk0x2q 373 19 the the DT cord-007796-zggk0x2q 373 20 presence presence NN cord-007796-zggk0x2q 373 21 of of IN cord-007796-zggk0x2q 373 22 virus virus NN cord-007796-zggk0x2q 373 23 is be VBZ cord-007796-zggk0x2q 373 24 no no DT cord-007796-zggk0x2q 373 25 longer long RBR cord-007796-zggk0x2q 373 26 required require VBN cord-007796-zggk0x2q 373 27 for for IN cord-007796-zggk0x2q 373 28 the the DT cord-007796-zggk0x2q 373 29 persistence persistence NN cord-007796-zggk0x2q 373 30 of of IN cord-007796-zggk0x2q 373 31 symptoms symptom NNS cord-007796-zggk0x2q 373 32 . . . cord-007796-zggk0x2q 374 1 It -PRON- PRP cord-007796-zggk0x2q 374 2 is be VBZ cord-007796-zggk0x2q 374 3 speculated speculate VBN cord-007796-zggk0x2q 374 4 that that IN cord-007796-zggk0x2q 374 5 primary primary JJ cord-007796-zggk0x2q 374 6 paramyxoviral paramyxoviral JJ cord-007796-zggk0x2q 374 7 infection infection NN cord-007796-zggk0x2q 374 8 within within IN cord-007796-zggk0x2q 374 9 the the DT cord-007796-zggk0x2q 374 10 proper proper JJ cord-007796-zggk0x2q 374 11 genetic genetic JJ cord-007796-zggk0x2q 374 12 background background NN cord-007796-zggk0x2q 374 13 may may MD cord-007796-zggk0x2q 374 14 result result VB cord-007796-zggk0x2q 374 15 in in IN cord-007796-zggk0x2q 374 16 chronic chronic JJ cord-007796-zggk0x2q 374 17 dysfunction dysfunction NN cord-007796-zggk0x2q 374 18 of of IN cord-007796-zggk0x2q 374 19 epithelial epithelial JJ cord-007796-zggk0x2q 374 20 cell cell NN cord-007796-zggk0x2q 374 21 behavior behavior NN cord-007796-zggk0x2q 374 22 . . . cord-007796-zggk0x2q 375 1 Their -PRON- PRP$ cord-007796-zggk0x2q 375 2 results result NNS cord-007796-zggk0x2q 375 3 have have VBP cord-007796-zggk0x2q 375 4 indicated indicate VBN cord-007796-zggk0x2q 375 5 that that IN cord-007796-zggk0x2q 375 6 different different JJ cord-007796-zggk0x2q 375 7 mechanisms mechanism NNS cord-007796-zggk0x2q 375 8 are be VBP cord-007796-zggk0x2q 375 9 responsible responsible JJ cord-007796-zggk0x2q 375 10 for for IN cord-007796-zggk0x2q 375 11 the the DT cord-007796-zggk0x2q 375 12 induction induction NN cord-007796-zggk0x2q 375 13 of of IN cord-007796-zggk0x2q 375 14 the the DT cord-007796-zggk0x2q 375 15 acute acute NN cord-007796-zggk0x2q 375 16 and and CC cord-007796-zggk0x2q 375 17 the the DT cord-007796-zggk0x2q 375 18 chronic chronic JJ cord-007796-zggk0x2q 375 19 response response NN cord-007796-zggk0x2q 375 20 ( ( -LRB- cord-007796-zggk0x2q 375 21 Walter Walter NNP cord-007796-zggk0x2q 375 22 et et NNP cord-007796-zggk0x2q 375 23 al al NNP cord-007796-zggk0x2q 375 24 . . NNP cord-007796-zggk0x2q 375 25 , , , cord-007796-zggk0x2q 375 26 2002 2002 CD cord-007796-zggk0x2q 375 27 ) ) -RRB- cord-007796-zggk0x2q 375 28 . . . cord-007796-zggk0x2q 376 1 Several several JJ cord-007796-zggk0x2q 376 2 theories theory NNS cord-007796-zggk0x2q 376 3 on on IN cord-007796-zggk0x2q 376 4 the the DT cord-007796-zggk0x2q 376 5 induction induction NN cord-007796-zggk0x2q 376 6 of of IN cord-007796-zggk0x2q 376 7 asthma asthma NN cord-007796-zggk0x2q 376 8 have have VBP cord-007796-zggk0x2q 376 9 thus thus RB cord-007796-zggk0x2q 376 10 been be VBN cord-007796-zggk0x2q 376 11 proposed propose VBN cord-007796-zggk0x2q 376 12 . . . cord-007796-zggk0x2q 377 1 The the DT cord-007796-zggk0x2q 377 2 current current JJ cord-007796-zggk0x2q 377 3 view view NN cord-007796-zggk0x2q 377 4 is be VBZ cord-007796-zggk0x2q 377 5 that that IN cord-007796-zggk0x2q 377 6 virus virus NN cord-007796-zggk0x2q 377 7 infection infection NN cord-007796-zggk0x2q 377 8 modulates modulate VBZ cord-007796-zggk0x2q 377 9 the the DT cord-007796-zggk0x2q 377 10 development development NN cord-007796-zggk0x2q 377 11 of of IN cord-007796-zggk0x2q 377 12 an an DT cord-007796-zggk0x2q 377 13 asthmatic asthmatic JJ cord-007796-zggk0x2q 377 14 phenotype phenotype NN cord-007796-zggk0x2q 377 15 in in IN cord-007796-zggk0x2q 377 16 a a DT cord-007796-zggk0x2q 377 17 susceptible susceptible JJ cord-007796-zggk0x2q 377 18 host host NN cord-007796-zggk0x2q 377 19 . . . cord-007796-zggk0x2q 378 1 The the DT cord-007796-zggk0x2q 378 2 relationship relationship NN cord-007796-zggk0x2q 378 3 is be VBZ cord-007796-zggk0x2q 378 4 , , , cord-007796-zggk0x2q 378 5 therefore therefore RB cord-007796-zggk0x2q 378 6 , , , cord-007796-zggk0x2q 378 7 not not RB cord-007796-zggk0x2q 378 8 purely purely RB cord-007796-zggk0x2q 378 9 causal causal JJ cord-007796-zggk0x2q 378 10 but but CC cord-007796-zggk0x2q 378 11 certainly certainly RB cord-007796-zggk0x2q 378 12 requires require VBZ cord-007796-zggk0x2q 378 13 an an DT cord-007796-zggk0x2q 378 14 intrinsic intrinsic JJ cord-007796-zggk0x2q 378 15 vulnerability vulnerability NN cord-007796-zggk0x2q 378 16 . . . cord-007796-zggk0x2q 379 1 The the DT cord-007796-zggk0x2q 379 2 effectiveness effectiveness NN cord-007796-zggk0x2q 379 3 of of IN cord-007796-zggk0x2q 379 4 respiratory respiratory JJ cord-007796-zggk0x2q 379 5 virus virus NN cord-007796-zggk0x2q 379 6 infections infection NNS cord-007796-zggk0x2q 379 7 in in IN cord-007796-zggk0x2q 379 8 the the DT cord-007796-zggk0x2q 379 9 host host NN cord-007796-zggk0x2q 379 10 depends depend VBZ cord-007796-zggk0x2q 379 11 partly partly RB cord-007796-zggk0x2q 379 12 on on IN cord-007796-zggk0x2q 379 13 the the DT cord-007796-zggk0x2q 379 14 ability ability NN cord-007796-zggk0x2q 379 15 to to TO cord-007796-zggk0x2q 379 16 evade evade VB cord-007796-zggk0x2q 379 17 the the DT cord-007796-zggk0x2q 379 18 immune immune JJ cord-007796-zggk0x2q 379 19 system system NN cord-007796-zggk0x2q 379 20 ( ( -LRB- cord-007796-zggk0x2q 379 21 Figure figure NN cord-007796-zggk0x2q 379 22 4 4 CD cord-007796-zggk0x2q 379 23 .2 .2 CD cord-007796-zggk0x2q 379 24 ) ) -RRB- cord-007796-zggk0x2q 379 25 . . . cord-007796-zggk0x2q 380 1 While while IN cord-007796-zggk0x2q 380 2 several several JJ cord-007796-zggk0x2q 380 3 viral viral JJ cord-007796-zggk0x2q 380 4 evasion evasion NN cord-007796-zggk0x2q 380 5 mechanisms mechanism NNS cord-007796-zggk0x2q 380 6 have have VBP cord-007796-zggk0x2q 380 7 evolved evolve VBN cord-007796-zggk0x2q 380 8 , , , cord-007796-zggk0x2q 380 9 not not RB cord-007796-zggk0x2q 380 10 all all DT cord-007796-zggk0x2q 380 11 have have VBP cord-007796-zggk0x2q 380 12 been be VBN cord-007796-zggk0x2q 380 13 intensively intensively RB cord-007796-zggk0x2q 380 14 studied study VBN cord-007796-zggk0x2q 380 15 in in IN cord-007796-zggk0x2q 380 16 respiratory respiratory JJ cord-007796-zggk0x2q 380 17 viruses virus NNS cord-007796-zggk0x2q 380 18 . . . cord-007796-zggk0x2q 381 1 Viral viral JJ cord-007796-zggk0x2q 381 2 entry entry NN cord-007796-zggk0x2q 381 3 into into IN cord-007796-zggk0x2q 381 4 host host NN cord-007796-zggk0x2q 381 5 cells cell NNS cord-007796-zggk0x2q 381 6 is be VBZ cord-007796-zggk0x2q 381 7 one one CD cord-007796-zggk0x2q 381 8 of of IN cord-007796-zggk0x2q 381 9 the the DT cord-007796-zggk0x2q 381 10 first first JJ cord-007796-zggk0x2q 381 11 obstacles obstacle NNS cord-007796-zggk0x2q 381 12 viruses virus NNS cord-007796-zggk0x2q 381 13 have have VBP cord-007796-zggk0x2q 381 14 to to TO cord-007796-zggk0x2q 381 15 overcome overcome VB cord-007796-zggk0x2q 381 16 . . . cord-007796-zggk0x2q 382 1 Since since IN cord-007796-zggk0x2q 382 2 the the DT cord-007796-zggk0x2q 382 3 cell cell NN cord-007796-zggk0x2q 382 4 membrane membrane NN cord-007796-zggk0x2q 382 5 is be VBZ cord-007796-zggk0x2q 382 6 in in IN cord-007796-zggk0x2q 382 7 principle principle NN cord-007796-zggk0x2q 382 8 impermeable impermeable JJ cord-007796-zggk0x2q 382 9 to to IN cord-007796-zggk0x2q 382 10 macromolecules macromolecule NNS cord-007796-zggk0x2q 382 11 , , , cord-007796-zggk0x2q 382 12 viruses virus NNS cord-007796-zggk0x2q 382 13 56 56 CD cord-007796-zggk0x2q 382 14 Caroline Caroline NNP cord-007796-zggk0x2q 382 15 A. A. NNP cord-007796-zggk0x2q 382 16 Lindemans Lindemans NNPS cord-007796-zggk0x2q 382 17 and and CC cord-007796-zggk0x2q 382 18 Jan Jan NNP cord-007796-zggk0x2q 382 19 L. L. NNP cord-007796-zggk0x2q 382 20 L. L. NNP cord-007796-zggk0x2q 382 21 Kimpen Kimpen NNP cord-007796-zggk0x2q 382 22 must must MD cord-007796-zggk0x2q 382 23 first first RB cord-007796-zggk0x2q 382 24 have have VB cord-007796-zggk0x2q 382 25 an an DT cord-007796-zggk0x2q 382 26 effective effective JJ cord-007796-zggk0x2q 382 27 method method NN cord-007796-zggk0x2q 382 28 to to TO cord-007796-zggk0x2q 382 29 attach attach VB cord-007796-zggk0x2q 382 30 to to IN cord-007796-zggk0x2q 382 31 the the DT cord-007796-zggk0x2q 382 32 cell cell NN cord-007796-zggk0x2q 382 33 membrane membrane NN cord-007796-zggk0x2q 382 34 . . . cord-007796-zggk0x2q 383 1 Some some DT cord-007796-zggk0x2q 383 2 viruses virus NNS cord-007796-zggk0x2q 383 3 bind bind VBP cord-007796-zggk0x2q 383 4 putative putative JJ cord-007796-zggk0x2q 383 5 cell cell NN cord-007796-zggk0x2q 383 6 surface surface NN cord-007796-zggk0x2q 383 7 receptors receptor NNS cord-007796-zggk0x2q 383 8 that that WDT cord-007796-zggk0x2q 383 9 do do VBP cord-007796-zggk0x2q 383 10 not not RB cord-007796-zggk0x2q 383 11 simply simply RB cord-007796-zggk0x2q 383 12 play play VB cord-007796-zggk0x2q 383 13 a a DT cord-007796-zggk0x2q 383 14 role role NN cord-007796-zggk0x2q 383 15 in in IN cord-007796-zggk0x2q 383 16 viral viral JJ cord-007796-zggk0x2q 383 17 attachment attachment NN cord-007796-zggk0x2q 383 18 , , , cord-007796-zggk0x2q 383 19 but but CC cord-007796-zggk0x2q 383 20 also also RB cord-007796-zggk0x2q 383 21 allow allow VB cord-007796-zggk0x2q 383 22 viral viral JJ cord-007796-zggk0x2q 383 23 entry entry NN cord-007796-zggk0x2q 383 24 by by IN cord-007796-zggk0x2q 383 25 inducing induce VBG cord-007796-zggk0x2q 383 26 endocytosis endocytosis NN cord-007796-zggk0x2q 383 27 . . . cord-007796-zggk0x2q 384 1 For for IN cord-007796-zggk0x2q 384 2 some some DT cord-007796-zggk0x2q 384 3 viral viral JJ cord-007796-zggk0x2q 384 4 pathogens pathogen NNS cord-007796-zggk0x2q 384 5 , , , cord-007796-zggk0x2q 384 6 such such JJ cord-007796-zggk0x2q 384 7 as as IN cord-007796-zggk0x2q 384 8 rhinovirus rhinovirus NN cord-007796-zggk0x2q 384 9 , , , cord-007796-zggk0x2q 384 10 these these DT cord-007796-zggk0x2q 384 11 receptors receptor NNS cord-007796-zggk0x2q 384 12 have have VBP cord-007796-zggk0x2q 384 13 been be VBN cord-007796-zggk0x2q 384 14 identified identify VBN cord-007796-zggk0x2q 384 15 ( ( -LRB- cord-007796-zggk0x2q 384 16 ICAM-1 ICAM-1 NNP cord-007796-zggk0x2q 384 17 and and CC cord-007796-zggk0x2q 384 18 LDL ldl NN cord-007796-zggk0x2q 384 19 - - HYPH cord-007796-zggk0x2q 384 20 R R NNP cord-007796-zggk0x2q 384 21 ) ) -RRB- cord-007796-zggk0x2q 384 22 , , , cord-007796-zggk0x2q 384 23 while while IN cord-007796-zggk0x2q 384 24 for for IN cord-007796-zggk0x2q 384 25 others other NNS cord-007796-zggk0x2q 384 26 , , , cord-007796-zggk0x2q 384 27 such such JJ cord-007796-zggk0x2q 384 28 as as IN cord-007796-zggk0x2q 384 29 RSV RSV NNP cord-007796-zggk0x2q 384 30 , , , cord-007796-zggk0x2q 384 31 the the DT cord-007796-zggk0x2q 384 32 receptor receptor NN cord-007796-zggk0x2q 384 33 that that WDT cord-007796-zggk0x2q 384 34 is be VBZ cord-007796-zggk0x2q 384 35 used use VBN cord-007796-zggk0x2q 384 36 for for IN cord-007796-zggk0x2q 384 37 cellular cellular JJ cord-007796-zggk0x2q 384 38 entry entry NN cord-007796-zggk0x2q 384 39 has have VBZ cord-007796-zggk0x2q 384 40 not not RB cord-007796-zggk0x2q 384 41 been be VBN cord-007796-zggk0x2q 384 42 unequivocally unequivocally RB cord-007796-zggk0x2q 384 43 defined define VBN cord-007796-zggk0x2q 384 44 . . . cord-007796-zggk0x2q 385 1 The the DT cord-007796-zggk0x2q 385 2 CX3CR1-chemokine cx3cr1-chemokine NN cord-007796-zggk0x2q 385 3 receptor receptor NN cord-007796-zggk0x2q 385 4 , , , cord-007796-zggk0x2q 385 5 also also RB cord-007796-zggk0x2q 385 6 known know VBN cord-007796-zggk0x2q 385 7 as as IN cord-007796-zggk0x2q 385 8 fractalkine fractalkine JJ cord-007796-zggk0x2q 385 9 - - HYPH cord-007796-zggk0x2q 385 10 receptor receptor NN cord-007796-zggk0x2q 385 11 , , , cord-007796-zggk0x2q 385 12 may may MD cord-007796-zggk0x2q 385 13 be be VB cord-007796-zggk0x2q 385 14 involved involve VBN cord-007796-zggk0x2q 385 15 and and CC cord-007796-zggk0x2q 385 16 TLRs tlr NNS cord-007796-zggk0x2q 385 17 have have VBP cord-007796-zggk0x2q 385 18 also also RB cord-007796-zggk0x2q 385 19 been be VBN cord-007796-zggk0x2q 385 20 proposed propose VBN cord-007796-zggk0x2q 385 21 to to TO cord-007796-zggk0x2q 385 22 play play VB cord-007796-zggk0x2q 385 23 a a DT cord-007796-zggk0x2q 385 24 role role NN cord-007796-zggk0x2q 385 25 . . . cord-007796-zggk0x2q 386 1 Many many JJ cord-007796-zggk0x2q 386 2 enveloped envelop VBN cord-007796-zggk0x2q 386 3 viruses virus NNS cord-007796-zggk0x2q 386 4 have have VBP cord-007796-zggk0x2q 386 5 glycosylated glycosylate VBN cord-007796-zggk0x2q 386 6 proteins protein NNS cord-007796-zggk0x2q 386 7 , , , cord-007796-zggk0x2q 386 8 which which WDT cord-007796-zggk0x2q 386 9 not not RB cord-007796-zggk0x2q 386 10 only only RB cord-007796-zggk0x2q 386 11 bind bind VBP cord-007796-zggk0x2q 386 12 to to IN cord-007796-zggk0x2q 386 13 cellular cellular JJ cord-007796-zggk0x2q 386 14 receptors receptor NNS cord-007796-zggk0x2q 386 15 , , , cord-007796-zggk0x2q 386 16 but but CC cord-007796-zggk0x2q 386 17 also also RB cord-007796-zggk0x2q 386 18 have have VBP cord-007796-zggk0x2q 386 19 additional additional JJ cord-007796-zggk0x2q 386 20 functions function NNS cord-007796-zggk0x2q 386 21 as as IN cord-007796-zggk0x2q 386 22 membrane membrane NN cord-007796-zggk0x2q 386 23 fusion fusion NN cord-007796-zggk0x2q 386 24 factors factor NNS cord-007796-zggk0x2q 386 25 , , , cord-007796-zggk0x2q 386 26 or or CC cord-007796-zggk0x2q 386 27 receptor receptor NN cord-007796-zggk0x2q 386 28 - - HYPH cord-007796-zggk0x2q 386 29 destroying destroy VBG cord-007796-zggk0x2q 386 30 enzymatic enzymatic JJ cord-007796-zggk0x2q 386 31 activity activity NN cord-007796-zggk0x2q 386 32 . . . cord-007796-zggk0x2q 387 1 Membrane membrane NN cord-007796-zggk0x2q 387 2 fusion fusion NN cord-007796-zggk0x2q 387 3 factors factor NNS cord-007796-zggk0x2q 387 4 such such JJ cord-007796-zggk0x2q 387 5 as as IN cord-007796-zggk0x2q 387 6 the the DT cord-007796-zggk0x2q 387 7 RSV RSV NNP cord-007796-zggk0x2q 387 8 Fprotein Fprotein NNP cord-007796-zggk0x2q 387 9 also also RB cord-007796-zggk0x2q 387 10 allow allow VBP cord-007796-zggk0x2q 387 11 cell cell NN cord-007796-zggk0x2q 387 12 - - HYPH cord-007796-zggk0x2q 387 13 to to IN cord-007796-zggk0x2q 387 14 - - HYPH cord-007796-zggk0x2q 387 15 cell cell NN cord-007796-zggk0x2q 387 16 transmission transmission NN cord-007796-zggk0x2q 387 17 of of IN cord-007796-zggk0x2q 387 18 virus virus NN cord-007796-zggk0x2q 387 19 , , , cord-007796-zggk0x2q 387 20 which which WDT cord-007796-zggk0x2q 387 21 keeps keep VBZ cord-007796-zggk0x2q 387 22 it -PRON- PRP cord-007796-zggk0x2q 387 23 relatively relatively RB cord-007796-zggk0x2q 387 24 hidden hidden JJ cord-007796-zggk0x2q 387 25 from from IN cord-007796-zggk0x2q 387 26 the the DT cord-007796-zggk0x2q 387 27 cellular cellular JJ cord-007796-zggk0x2q 387 28 immune immune JJ cord-007796-zggk0x2q 387 29 system system NN cord-007796-zggk0x2q 387 30 ( ( -LRB- cord-007796-zggk0x2q 387 31 Smith Smith NNP cord-007796-zggk0x2q 387 32 and and CC cord-007796-zggk0x2q 387 33 Helenius Helenius NNP cord-007796-zggk0x2q 387 34 , , , cord-007796-zggk0x2q 387 35 2004 2004 CD cord-007796-zggk0x2q 387 36 ) ) -RRB- cord-007796-zggk0x2q 387 37 . . . cord-007796-zggk0x2q 388 1 Escaping escape VBG cord-007796-zggk0x2q 388 2 the the DT cord-007796-zggk0x2q 388 3 " " `` cord-007796-zggk0x2q 388 4 interferon interferon NN cord-007796-zggk0x2q 388 5 signaling signal VBG cord-007796-zggk0x2q 388 6 system system NN cord-007796-zggk0x2q 388 7 " " '' cord-007796-zggk0x2q 388 8 is be VBZ cord-007796-zggk0x2q 388 9 one one CD cord-007796-zggk0x2q 388 10 of of IN cord-007796-zggk0x2q 388 11 the the DT cord-007796-zggk0x2q 388 12 common common JJ cord-007796-zggk0x2q 388 13 mechanisms mechanism NNS cord-007796-zggk0x2q 388 14 most most JJS cord-007796-zggk0x2q 388 15 viruses virus NNS cord-007796-zggk0x2q 388 16 have have VBP cord-007796-zggk0x2q 388 17 acquired acquire VBN cord-007796-zggk0x2q 388 18 . . . cord-007796-zggk0x2q 389 1 As as IN cord-007796-zggk0x2q 389 2 mentioned mention VBN cord-007796-zggk0x2q 389 3 earlier early RBR cord-007796-zggk0x2q 389 4 in in IN cord-007796-zggk0x2q 389 5 this this DT cord-007796-zggk0x2q 389 6 chapter chapter NN cord-007796-zggk0x2q 389 7 , , , cord-007796-zggk0x2q 389 8 both both DT cord-007796-zggk0x2q 389 9 IFN- IFN- NNP cord-007796-zggk0x2q 389 10 ␣ ␣ NNP cord-007796-zggk0x2q 389 11 / / SYM cord-007796-zggk0x2q 389 12 ␤ ␤ NNP cord-007796-zggk0x2q 389 13 and and CC cord-007796-zggk0x2q 389 14 IFN- IFN- NNP cord-007796-zggk0x2q 389 15 ␥ ␥ ADD cord-007796-zggk0x2q 389 16 have have VBP cord-007796-zggk0x2q 389 17 potent potent JJ cord-007796-zggk0x2q 389 18 antiviral antiviral JJ cord-007796-zggk0x2q 389 19 properties property NNS cord-007796-zggk0x2q 389 20 . . . cord-007796-zggk0x2q 390 1 Both both DT cord-007796-zggk0x2q 390 2 types type NNS cord-007796-zggk0x2q 390 3 of of IN cord-007796-zggk0x2q 390 4 interferon interferon NN cord-007796-zggk0x2q 390 5 regulate regulate VBP cord-007796-zggk0x2q 390 6 transcription transcription NN cord-007796-zggk0x2q 390 7 of of IN cord-007796-zggk0x2q 390 8 a a DT cord-007796-zggk0x2q 390 9 variety variety NN cord-007796-zggk0x2q 390 10 of of IN cord-007796-zggk0x2q 390 11 target target NN cord-007796-zggk0x2q 390 12 genes gene NNS cord-007796-zggk0x2q 390 13 through through IN cord-007796-zggk0x2q 390 14 activation activation NN cord-007796-zggk0x2q 390 15 of of IN cord-007796-zggk0x2q 390 16 interferon interferon NN cord-007796-zggk0x2q 390 17 inducible inducible JJ cord-007796-zggk0x2q 390 18 transcription transcription NN cord-007796-zggk0x2q 390 19 factors factor NNS cord-007796-zggk0x2q 390 20 . . . cord-007796-zggk0x2q 391 1 IFN IFN NNP cord-007796-zggk0x2q 391 2 - - HYPH cord-007796-zggk0x2q 391 3 stimulated stimulate VBN cord-007796-zggk0x2q 391 4 genes gene NNS cord-007796-zggk0x2q 391 5 encode encode VBP cord-007796-zggk0x2q 391 6 a a DT cord-007796-zggk0x2q 391 7 variety variety NN cord-007796-zggk0x2q 391 8 of of IN cord-007796-zggk0x2q 391 9 cellular cellular JJ cord-007796-zggk0x2q 391 10 enzymes enzyme NNS cord-007796-zggk0x2q 391 11 , , , cord-007796-zggk0x2q 391 12 including include VBG cord-007796-zggk0x2q 391 13 PKR PKR NNP cord-007796-zggk0x2q 391 14 and and CC cord-007796-zggk0x2q 391 15 2Ј5 2ј5 CD cord-007796-zggk0x2q 391 16 Ј-oligoadenylate Ј-oligoadenylate NNP cord-007796-zggk0x2q 391 17 synthetase synthetase NN cord-007796-zggk0x2q 391 18 , , , cord-007796-zggk0x2q 391 19 both both DT cord-007796-zggk0x2q 391 20 involved involve VBN cord-007796-zggk0x2q 391 21 in in IN cord-007796-zggk0x2q 391 22 inhibition inhibition NN cord-007796-zggk0x2q 391 23 of of IN cord-007796-zggk0x2q 391 24 viral viral JJ cord-007796-zggk0x2q 391 25 protein protein NN cord-007796-zggk0x2q 391 26 synthesis synthesis NN cord-007796-zggk0x2q 391 27 . . . cord-007796-zggk0x2q 392 1 Furthermore furthermore RB cord-007796-zggk0x2q 392 2 , , , cord-007796-zggk0x2q 392 3 interferons interferon NNS cord-007796-zggk0x2q 392 4 induce induce VBP cord-007796-zggk0x2q 392 5 cellular cellular JJ cord-007796-zggk0x2q 392 6 apoptosis apoptosis NN cord-007796-zggk0x2q 392 7 and and CC cord-007796-zggk0x2q 392 8 upregulate upregulate VB cord-007796-zggk0x2q 392 9 MHC1 MHC1 NNP cord-007796-zggk0x2q 392 10 expression expression NN cord-007796-zggk0x2q 392 11 , , , cord-007796-zggk0x2q 392 12 targeting target VBG cord-007796-zggk0x2q 392 13 cells cell NNS cord-007796-zggk0x2q 392 14 for for IN cord-007796-zggk0x2q 392 15 CD8ϩ CD8ϩ NNP cord-007796-zggk0x2q 392 16 T T NNP cord-007796-zggk0x2q 392 17 - - HYPH cord-007796-zggk0x2q 392 18 cell cell NN cord-007796-zggk0x2q 392 19 - - HYPH cord-007796-zggk0x2q 392 20 mediated mediate VBN cord-007796-zggk0x2q 392 21 cytotoxicity cytotoxicity NN cord-007796-zggk0x2q 392 22 . . . cord-007796-zggk0x2q 393 1 Additionally additionally RB cord-007796-zggk0x2q 393 2 , , , cord-007796-zggk0x2q 393 3 IFN- IFN- NNP cord-007796-zggk0x2q 393 4 ␥ ␥ NNP cord-007796-zggk0x2q 393 5 activates activate VBZ cord-007796-zggk0x2q 393 6 the the DT cord-007796-zggk0x2q 393 7 adaptive adaptive JJ cord-007796-zggk0x2q 393 8 cellular cellular JJ cord-007796-zggk0x2q 393 9 immune immune JJ cord-007796-zggk0x2q 393 10 system system NN cord-007796-zggk0x2q 393 11 . . . cord-007796-zggk0x2q 394 1 RSV RSV NNP cord-007796-zggk0x2q 394 2 infection infection NN cord-007796-zggk0x2q 394 3 leads lead VBZ cord-007796-zggk0x2q 394 4 to to IN cord-007796-zggk0x2q 394 5 an an DT cord-007796-zggk0x2q 394 6 increase increase NN cord-007796-zggk0x2q 394 7 in in IN cord-007796-zggk0x2q 394 8 IFN- IFN- NNP cord-007796-zggk0x2q 394 9 ␣ ␣ NNP cord-007796-zggk0x2q 394 10 / / SYM cord-007796-zggk0x2q 394 11 ␤ ␤ CC cord-007796-zggk0x2q 394 12 , , , cord-007796-zggk0x2q 394 13 but but CC cord-007796-zggk0x2q 394 14 does do VBZ cord-007796-zggk0x2q 394 15 not not RB cord-007796-zggk0x2q 394 16 induce induce VB cord-007796-zggk0x2q 394 17 IFN- IFN- NNP cord-007796-zggk0x2q 394 18 ␥ ␥ NNP cord-007796-zggk0x2q 394 19 from from IN cord-007796-zggk0x2q 394 20 mononuclear mononuclear JJ cord-007796-zggk0x2q 394 21 and and CC cord-007796-zggk0x2q 394 22 NK nk NN cord-007796-zggk0x2q 394 23 - - HYPH cord-007796-zggk0x2q 394 24 cells cell NNS cord-007796-zggk0x2q 394 25 as as RB cord-007796-zggk0x2q 394 26 efficiently efficiently RB cord-007796-zggk0x2q 394 27 . . . cord-007796-zggk0x2q 395 1 Despite despite IN cord-007796-zggk0x2q 395 2 the the DT cord-007796-zggk0x2q 395 3 fact fact NN cord-007796-zggk0x2q 395 4 that that IN cord-007796-zggk0x2q 395 5 interferons interferon NNS cord-007796-zggk0x2q 395 6 are be VBP cord-007796-zggk0x2q 395 7 known know VBN cord-007796-zggk0x2q 395 8 for for IN cord-007796-zggk0x2q 395 9 their -PRON- PRP$ cord-007796-zggk0x2q 395 10 antiviral antiviral JJ cord-007796-zggk0x2q 395 11 properties property NNS cord-007796-zggk0x2q 395 12 , , , cord-007796-zggk0x2q 395 13 intranasal intranasal NNP cord-007796-zggk0x2q 395 14 administration administration NN cord-007796-zggk0x2q 395 15 of of IN cord-007796-zggk0x2q 395 16 either either CC cord-007796-zggk0x2q 395 17 lFN- lFN- NNP cord-007796-zggk0x2q 396 1 ␣ ␣ NNP cord-007796-zggk0x2q 396 2 / / SYM cord-007796-zggk0x2q 396 3 ␤ ␤ NNP cord-007796-zggk0x2q 396 4 or or CC cord-007796-zggk0x2q 396 5 IFN- IFN- NNP cord-007796-zggk0x2q 396 6 ␥ ␥ NNP cord-007796-zggk0x2q 396 7 in in IN cord-007796-zggk0x2q 396 8 the the DT cord-007796-zggk0x2q 396 9 airway airway NN cord-007796-zggk0x2q 396 10 does do VBZ cord-007796-zggk0x2q 396 11 not not RB cord-007796-zggk0x2q 396 12 lead lead VB cord-007796-zggk0x2q 396 13 to to IN cord-007796-zggk0x2q 396 14 reduction reduction NN cord-007796-zggk0x2q 396 15 of of IN cord-007796-zggk0x2q 396 16 symptoms symptom NNS cord-007796-zggk0x2q 396 17 of of IN cord-007796-zggk0x2q 396 18 viral viral JJ cord-007796-zggk0x2q 396 19 respiratory respiratory JJ cord-007796-zggk0x2q 396 20 infections infection NNS cord-007796-zggk0x2q 396 21 ( ( -LRB- cord-007796-zggk0x2q 396 22 Ramaswamy Ramaswamy NNP cord-007796-zggk0x2q 396 23 et et NNP cord-007796-zggk0x2q 396 24 al al NNP cord-007796-zggk0x2q 396 25 . . NNP cord-007796-zggk0x2q 396 26 , , , cord-007796-zggk0x2q 396 27 2004 2004 CD cord-007796-zggk0x2q 396 28 ) ) -RRB- cord-007796-zggk0x2q 396 29 . . . cord-007796-zggk0x2q 397 1 This this DT cord-007796-zggk0x2q 397 2 is be VBZ cord-007796-zggk0x2q 397 3 suggestive suggestive JJ cord-007796-zggk0x2q 397 4 of of IN cord-007796-zggk0x2q 397 5 a a DT cord-007796-zggk0x2q 397 6 viral viral JJ cord-007796-zggk0x2q 397 7 mechanism mechanism NN cord-007796-zggk0x2q 397 8 to to TO cord-007796-zggk0x2q 397 9 evade evade VB cord-007796-zggk0x2q 397 10 the the DT cord-007796-zggk0x2q 397 11 host host NN cord-007796-zggk0x2q 397 12 's 's POS cord-007796-zggk0x2q 397 13 interferon interferon NN cord-007796-zggk0x2q 397 14 response response NN cord-007796-zggk0x2q 397 15 . . . cord-007796-zggk0x2q 398 1 The the DT cord-007796-zggk0x2q 398 2 Paramyxoviridae Paramyxoviridae NNP cord-007796-zggk0x2q 398 3 family family NN cord-007796-zggk0x2q 398 4 ( ( -LRB- cord-007796-zggk0x2q 398 5 Figure figure NN cord-007796-zggk0x2q 398 6 4 4 CD cord-007796-zggk0x2q 398 7 .3 .3 CD cord-007796-zggk0x2q 398 8 ) ) -RRB- cord-007796-zggk0x2q 398 9 , , , cord-007796-zggk0x2q 398 10 responsible responsible JJ cord-007796-zggk0x2q 398 11 for for IN cord-007796-zggk0x2q 398 12 a a DT cord-007796-zggk0x2q 398 13 large large JJ cord-007796-zggk0x2q 398 14 part part NN cord-007796-zggk0x2q 398 15 of of IN cord-007796-zggk0x2q 398 16 children child NNS cord-007796-zggk0x2q 398 17 's 's POS cord-007796-zggk0x2q 398 18 respiratory respiratory JJ cord-007796-zggk0x2q 398 19 infections infection NNS cord-007796-zggk0x2q 398 20 , , , cord-007796-zggk0x2q 398 21 consists consist VBZ cord-007796-zggk0x2q 398 22 of of IN cord-007796-zggk0x2q 398 23 two two CD cord-007796-zggk0x2q 398 24 subfamilies subfamily NNS cord-007796-zggk0x2q 398 25 based base VBN cord-007796-zggk0x2q 398 26 on on IN cord-007796-zggk0x2q 398 27 the the DT cord-007796-zggk0x2q 398 28 structural structural JJ cord-007796-zggk0x2q 398 29 differences difference NNS cord-007796-zggk0x2q 398 30 in in IN cord-007796-zggk0x2q 398 31 the the DT cord-007796-zggk0x2q 398 32 gene gene NN cord-007796-zggk0x2q 398 33 encoding encoding NN cord-007796-zggk0x2q 398 34 for for IN cord-007796-zggk0x2q 398 35 the the DT cord-007796-zggk0x2q 398 36 polymerase polymerase NN cord-007796-zggk0x2q 398 37 complex complex NN cord-007796-zggk0x2q 398 38 ( ( -LRB- cord-007796-zggk0x2q 398 39 P p NN cord-007796-zggk0x2q 398 40 - - HYPH cord-007796-zggk0x2q 398 41 protein protein NN cord-007796-zggk0x2q 398 42 ) ) -RRB- cord-007796-zggk0x2q 398 43 . . . cord-007796-zggk0x2q 399 1 The the DT cord-007796-zggk0x2q 399 2 Paramyxovirinae Paramyxovirinae NNP cord-007796-zggk0x2q 399 3 subfamily subfamily NN cord-007796-zggk0x2q 399 4 members member NNS cord-007796-zggk0x2q 399 5 are be VBP cord-007796-zggk0x2q 399 6 able able JJ cord-007796-zggk0x2q 399 7 to to TO cord-007796-zggk0x2q 399 8 block block VB cord-007796-zggk0x2q 399 9 interferon interferon NN cord-007796-zggk0x2q 399 10 - - HYPH cord-007796-zggk0x2q 399 11 mediated mediate VBN cord-007796-zggk0x2q 399 12 promoter promoter NN cord-007796-zggk0x2q 399 13 activity activity NN cord-007796-zggk0x2q 399 14 . . . cord-007796-zggk0x2q 400 1 These these DT cord-007796-zggk0x2q 400 2 paramyxovirinae paramyxovirinae NNP cord-007796-zggk0x2q 400 3 , , , cord-007796-zggk0x2q 400 4 to to TO cord-007796-zggk0x2q 400 5 which which WDT cord-007796-zggk0x2q 400 6 parainfluenza- parainfluenza- NNP cord-007796-zggk0x2q 400 7 , , , cord-007796-zggk0x2q 400 8 measles- measles- NN cord-007796-zggk0x2q 400 9 , , , cord-007796-zggk0x2q 400 10 and and CC cord-007796-zggk0x2q 400 11 mumps mumps NN cord-007796-zggk0x2q 400 12 virus virus NN cord-007796-zggk0x2q 400 13 belong belong VBP cord-007796-zggk0x2q 400 14 to to IN cord-007796-zggk0x2q 400 15 , , , cord-007796-zggk0x2q 400 16 have have VB cord-007796-zggk0x2q 400 17 a a DT cord-007796-zggk0x2q 400 18 P p NN cord-007796-zggk0x2q 400 19 - - HYPH cord-007796-zggk0x2q 400 20 gene gene NN cord-007796-zggk0x2q 400 21 that that WDT cord-007796-zggk0x2q 400 22 encodes encode VBZ cord-007796-zggk0x2q 400 23 for for IN cord-007796-zggk0x2q 400 24 additional additional JJ cord-007796-zggk0x2q 400 25 proteins protein NNS cord-007796-zggk0x2q 400 26 besides besides IN cord-007796-zggk0x2q 400 27 the the DT cord-007796-zggk0x2q 400 28 P p NN cord-007796-zggk0x2q 400 29 - - HYPH cord-007796-zggk0x2q 400 30 protein protein NN cord-007796-zggk0x2q 400 31 , , , cord-007796-zggk0x2q 400 32 the the DT cord-007796-zggk0x2q 400 33 V v NN cord-007796-zggk0x2q 400 34 - - HYPH cord-007796-zggk0x2q 400 35 proteins protein NNS cord-007796-zggk0x2q 400 36 . . . cord-007796-zggk0x2q 401 1 It -PRON- PRP cord-007796-zggk0x2q 401 2 is be VBZ cord-007796-zggk0x2q 401 3 these these DT cord-007796-zggk0x2q 401 4 V v NN cord-007796-zggk0x2q 401 5 - - HYPH cord-007796-zggk0x2q 401 6 proteins protein NNS cord-007796-zggk0x2q 401 7 that that WDT cord-007796-zggk0x2q 401 8 have have VBP cord-007796-zggk0x2q 401 9 been be VBN cord-007796-zggk0x2q 401 10 found find VBN cord-007796-zggk0x2q 401 11 to to TO cord-007796-zggk0x2q 401 12 be be VB cord-007796-zggk0x2q 401 13 responsible responsible JJ cord-007796-zggk0x2q 401 14 for for IN cord-007796-zggk0x2q 401 15 evading evade VBG cord-007796-zggk0x2q 401 16 the the DT cord-007796-zggk0x2q 401 17 interferon interferon NN cord-007796-zggk0x2q 401 18 signaling signal VBG cord-007796-zggk0x2q 401 19 pathways pathway NNS cord-007796-zggk0x2q 401 20 in in IN cord-007796-zggk0x2q 401 21 this this DT cord-007796-zggk0x2q 401 22 group group NN cord-007796-zggk0x2q 401 23 of of IN cord-007796-zggk0x2q 401 24 viruses virus NNS cord-007796-zggk0x2q 401 25 . . . cord-007796-zggk0x2q 402 1 IFNmediated ifnmediated JJ cord-007796-zggk0x2q 402 2 transcription transcription NN cord-007796-zggk0x2q 402 3 is be VBZ cord-007796-zggk0x2q 402 4 predominantly predominantly RB cord-007796-zggk0x2q 402 5 mediated mediate VBN cord-007796-zggk0x2q 402 6 by by IN cord-007796-zggk0x2q 402 7 signal signal NN cord-007796-zggk0x2q 402 8 transducers transducer NNS cord-007796-zggk0x2q 402 9 and and CC cord-007796-zggk0x2q 402 10 activators activator NNS cord-007796-zggk0x2q 402 11 of of IN cord-007796-zggk0x2q 402 12 transcription transcription NN cord-007796-zggk0x2q 402 13 ( ( -LRB- cord-007796-zggk0x2q 402 14 STAT stat NN cord-007796-zggk0x2q 402 15 ) ) -RRB- cord-007796-zggk0x2q 402 16 . . . cord-007796-zggk0x2q 403 1 V v NN cord-007796-zggk0x2q 403 2 - - HYPH cord-007796-zggk0x2q 403 3 proteins protein NNS cord-007796-zggk0x2q 403 4 have have VBP cord-007796-zggk0x2q 403 5 the the DT cord-007796-zggk0x2q 403 6 ability ability NN cord-007796-zggk0x2q 403 7 to to TO cord-007796-zggk0x2q 403 8 block block VB cord-007796-zggk0x2q 403 9 interferon interferon NN cord-007796-zggk0x2q 403 10 - - HYPH cord-007796-zggk0x2q 403 11 mediated mediate VBN cord-007796-zggk0x2q 403 12 signaling signaling NN cord-007796-zggk0x2q 403 13 by by IN cord-007796-zggk0x2q 403 14 targeting target VBG cord-007796-zggk0x2q 403 15 STATs stat NNS cord-007796-zggk0x2q 403 16 for for IN cord-007796-zggk0x2q 403 17 proteosomal proteosomal NNP cord-007796-zggk0x2q 403 18 degradation degradation NN cord-007796-zggk0x2q 403 19 ( ( -LRB- cord-007796-zggk0x2q 403 20 Horvath Horvath NNP cord-007796-zggk0x2q 403 21 , , , cord-007796-zggk0x2q 403 22 2004 2004 CD cord-007796-zggk0x2q 403 23 ) ) -RRB- cord-007796-zggk0x2q 403 24 . . . cord-007796-zggk0x2q 404 1 In in IN cord-007796-zggk0x2q 404 2 contrast contrast NN cord-007796-zggk0x2q 404 3 , , , cord-007796-zggk0x2q 404 4 RSV RSV NNP cord-007796-zggk0x2q 404 5 , , , cord-007796-zggk0x2q 404 6 belonging belong VBG cord-007796-zggk0x2q 404 7 to to IN cord-007796-zggk0x2q 404 8 the the DT cord-007796-zggk0x2q 404 9 Pneumovirinae Pneumovirinae NNP cord-007796-zggk0x2q 404 10 subfamily subfamily NN cord-007796-zggk0x2q 404 11 , , , cord-007796-zggk0x2q 404 12 fails fail VBZ cord-007796-zggk0x2q 404 13 to to TO cord-007796-zggk0x2q 404 14 inhibit inhibit VB cord-007796-zggk0x2q 404 15 IFN IFN NNP cord-007796-zggk0x2q 404 16 - - HYPH cord-007796-zggk0x2q 404 17 induced induce VBN cord-007796-zggk0x2q 404 18 promoter promoter NN cord-007796-zggk0x2q 404 19 activity activity NN cord-007796-zggk0x2q 404 20 . . . cord-007796-zggk0x2q 405 1 The the DT cord-007796-zggk0x2q 405 2 pneumovirinae pneumovirinae JJ cord-007796-zggk0x2q 405 3 consist consist VBP cord-007796-zggk0x2q 405 4 of of IN cord-007796-zggk0x2q 405 5 only only RB cord-007796-zggk0x2q 405 6 one one CD cord-007796-zggk0x2q 405 7 genus genus NN cord-007796-zggk0x2q 405 8 , , , cord-007796-zggk0x2q 405 9 the the DT cord-007796-zggk0x2q 405 10 pneumovirus pneumovirus NNP cord-007796-zggk0x2q 405 11 , , , cord-007796-zggk0x2q 405 12 which which WDT cord-007796-zggk0x2q 405 13 also also RB cord-007796-zggk0x2q 405 14 includes include VBZ cord-007796-zggk0x2q 405 15 hMPV hmpv NN cord-007796-zggk0x2q 405 16 . . . cord-007796-zggk0x2q 406 1 In in IN cord-007796-zggk0x2q 406 2 this this DT cord-007796-zggk0x2q 406 3 subfamily subfamily NN cord-007796-zggk0x2q 406 4 , , , cord-007796-zggk0x2q 406 5 P p NN cord-007796-zggk0x2q 406 6 - - HYPH cord-007796-zggk0x2q 406 7 genes gene NNS cord-007796-zggk0x2q 406 8 only only RB cord-007796-zggk0x2q 406 9 encode encode VBP cord-007796-zggk0x2q 406 10 for for IN cord-007796-zggk0x2q 406 11 the the DT cord-007796-zggk0x2q 406 12 P p NN cord-007796-zggk0x2q 406 13 - - HYPH cord-007796-zggk0x2q 406 14 protein protein NN cord-007796-zggk0x2q 406 15 and and CC cord-007796-zggk0x2q 406 16 therefore therefore RB cord-007796-zggk0x2q 406 17 RSV RSV NNP cord-007796-zggk0x2q 406 18 can can MD cord-007796-zggk0x2q 406 19 not not RB cord-007796-zggk0x2q 406 20 block block VB cord-007796-zggk0x2q 406 21 interferon interferon NN cord-007796-zggk0x2q 406 22 - - HYPH cord-007796-zggk0x2q 406 23 mediated mediate VBN cord-007796-zggk0x2q 406 24 signaling signaling NN cord-007796-zggk0x2q 407 1 ( ( -LRB- cord-007796-zggk0x2q 407 2 Young Young NNP cord-007796-zggk0x2q 407 3 et et FW cord-007796-zggk0x2q 407 4 al al NNP cord-007796-zggk0x2q 407 5 . . NNP cord-007796-zggk0x2q 407 6 , , , cord-007796-zggk0x2q 407 7 2000 2000 CD cord-007796-zggk0x2q 407 8 ) ) -RRB- cord-007796-zggk0x2q 407 9 . . . cord-007796-zggk0x2q 408 1 However however RB cord-007796-zggk0x2q 408 2 , , , cord-007796-zggk0x2q 408 3 recently recently RB cord-007796-zggk0x2q 408 4 it -PRON- PRP cord-007796-zggk0x2q 408 5 was be VBD cord-007796-zggk0x2q 408 6 demonstrated demonstrate VBN cord-007796-zggk0x2q 408 7 that that IN cord-007796-zggk0x2q 408 8 , , , cord-007796-zggk0x2q 408 9 although although IN cord-007796-zggk0x2q 408 10 RSV RSV NNP cord-007796-zggk0x2q 408 11 does do VBZ cord-007796-zggk0x2q 408 12 not not RB cord-007796-zggk0x2q 408 13 inhibit inhibit VB cord-007796-zggk0x2q 408 14 interferon interferon NN cord-007796-zggk0x2q 408 15 - - HYPH cord-007796-zggk0x2q 408 16 induced induce VBN cord-007796-zggk0x2q 408 17 promoter promoter NN cord-007796-zggk0x2q 408 18 activity activity NN cord-007796-zggk0x2q 408 19 , , , cord-007796-zggk0x2q 408 20 RSV RSV NNP cord-007796-zggk0x2q 408 21 replication replication NN cord-007796-zggk0x2q 408 22 is be VBZ cord-007796-zggk0x2q 408 23 still still RB cord-007796-zggk0x2q 408 24 resistant resistant JJ cord-007796-zggk0x2q 408 25 to to IN cord-007796-zggk0x2q 408 26 IFN IFN NNP cord-007796-zggk0x2q 408 27 treatment treatment NN cord-007796-zggk0x2q 408 28 of of IN cord-007796-zggk0x2q 408 29 infected infected JJ cord-007796-zggk0x2q 408 30 cells cell NNS cord-007796-zggk0x2q 408 31 . . . cord-007796-zggk0x2q 409 1 Apparently apparently RB cord-007796-zggk0x2q 409 2 , , , cord-007796-zggk0x2q 409 3 an an DT cord-007796-zggk0x2q 409 4 alternative alternative JJ cord-007796-zggk0x2q 409 5 mechanism mechanism NN cord-007796-zggk0x2q 409 6 to to TO cord-007796-zggk0x2q 409 7 circumvent circumvent VB cord-007796-zggk0x2q 409 8 the the DT cord-007796-zggk0x2q 409 9 interferon interferon NN cord-007796-zggk0x2q 409 10 antiviral antiviral JJ cord-007796-zggk0x2q 409 11 response response NN cord-007796-zggk0x2q 409 12 exists exist VBZ cord-007796-zggk0x2q 409 13 . . . cord-007796-zggk0x2q 410 1 This this DT cord-007796-zggk0x2q 410 2 has have VBZ cord-007796-zggk0x2q 410 3 been be VBN cord-007796-zggk0x2q 410 4 attributed attribute VBN cord-007796-zggk0x2q 410 5 to to IN cord-007796-zggk0x2q 410 6 additional additional JJ cord-007796-zggk0x2q 410 7 proteins protein NNS cord-007796-zggk0x2q 410 8 , , , cord-007796-zggk0x2q 410 9 characteristic characteristic JJ cord-007796-zggk0x2q 410 10 of of IN cord-007796-zggk0x2q 410 11 these these DT cord-007796-zggk0x2q 410 12 pneumoviruses pneumoviruse NNS cord-007796-zggk0x2q 410 13 ( ( -LRB- cord-007796-zggk0x2q 410 14 Spann Spann NNP cord-007796-zggk0x2q 410 15 et et NNP cord-007796-zggk0x2q 410 16 al al NNP cord-007796-zggk0x2q 410 17 . . NNP cord-007796-zggk0x2q 410 18 , , , cord-007796-zggk0x2q 410 19 2004 2004 CD cord-007796-zggk0x2q 410 20 ) ) -RRB- cord-007796-zggk0x2q 410 21 . . . cord-007796-zggk0x2q 411 1 These these DT cord-007796-zggk0x2q 411 2 are be VBP cord-007796-zggk0x2q 411 3 nonstructural nonstructural JJ cord-007796-zggk0x2q 411 4 proteins protein NNS cord-007796-zggk0x2q 411 5 ( ( -LRB- cord-007796-zggk0x2q 411 6 NS1 NS1 NNS cord-007796-zggk0x2q 411 7 and and CC cord-007796-zggk0x2q 411 8 NS2 NS2 NNP cord-007796-zggk0x2q 411 9 ) ) -RRB- cord-007796-zggk0x2q 411 10 that that WDT cord-007796-zggk0x2q 411 11 have have VBP cord-007796-zggk0x2q 411 12 no no DT cord-007796-zggk0x2q 411 13 homologs homolog NNS cord-007796-zggk0x2q 411 14 in in IN cord-007796-zggk0x2q 411 15 the the DT cord-007796-zggk0x2q 411 16 paramyxovirinae paramyxovirinae NNP cord-007796-zggk0x2q 411 17 . . . cord-007796-zggk0x2q 412 1 However however RB cord-007796-zggk0x2q 412 2 , , , cord-007796-zggk0x2q 412 3 the the DT cord-007796-zggk0x2q 412 4 underlying underlying JJ cord-007796-zggk0x2q 412 5 molecular molecular JJ cord-007796-zggk0x2q 412 6 pathway pathway NN cord-007796-zggk0x2q 412 7 has have VBZ cord-007796-zggk0x2q 412 8 not not RB cord-007796-zggk0x2q 412 9 yet yet RB cord-007796-zggk0x2q 412 10 been be VBN cord-007796-zggk0x2q 412 11 elucidated elucidate VBN cord-007796-zggk0x2q 412 12 . . . cord-007796-zggk0x2q 413 1 RSV RSV NNP cord-007796-zggk0x2q 413 2 infection infection NN cord-007796-zggk0x2q 413 3 of of IN cord-007796-zggk0x2q 413 4 epithelial epithelial NN cord-007796-zggk0x2q 413 5 has have VBZ cord-007796-zggk0x2q 413 6 been be VBN cord-007796-zggk0x2q 413 7 shown show VBN cord-007796-zggk0x2q 413 8 to to TO cord-007796-zggk0x2q 413 9 lead lead VB cord-007796-zggk0x2q 413 10 to to IN cord-007796-zggk0x2q 413 11 an an DT cord-007796-zggk0x2q 413 12 upregulation upregulation NN cord-007796-zggk0x2q 413 13 of of IN cord-007796-zggk0x2q 413 14 TRAIL trail NN cord-007796-zggk0x2q 413 15 - - HYPH cord-007796-zggk0x2q 413 16 receptor receptor NN cord-007796-zggk0x2q 413 17 expression expression NN cord-007796-zggk0x2q 413 18 on on IN cord-007796-zggk0x2q 413 19 these these DT cord-007796-zggk0x2q 413 20 cells cell NNS cord-007796-zggk0x2q 413 21 ( ( -LRB- cord-007796-zggk0x2q 413 22 Kotelkin Kotelkin NNP cord-007796-zggk0x2q 413 23 et et FW cord-007796-zggk0x2q 413 24 al al NNP cord-007796-zggk0x2q 413 25 . . NNP cord-007796-zggk0x2q 413 26 , , , cord-007796-zggk0x2q 413 27 2003 2003 CD cord-007796-zggk0x2q 413 28 ) ) -RRB- cord-007796-zggk0x2q 413 29 . . . cord-007796-zggk0x2q 414 1 Apoptosis apoptosis NN cord-007796-zggk0x2q 414 2 of of IN cord-007796-zggk0x2q 414 3 infected infected JJ cord-007796-zggk0x2q 414 4 cells cell NNS cord-007796-zggk0x2q 414 5 is be VBZ cord-007796-zggk0x2q 414 6 an an DT cord-007796-zggk0x2q 414 7 effective effective JJ cord-007796-zggk0x2q 414 8 way way NN cord-007796-zggk0x2q 414 9 to to TO cord-007796-zggk0x2q 414 10 eliminate eliminate VB cord-007796-zggk0x2q 414 11 intracellular intracellular JJ cord-007796-zggk0x2q 414 12 pathogens pathogen NNS cord-007796-zggk0x2q 414 13 without without IN cord-007796-zggk0x2q 414 14 damage damage NN cord-007796-zggk0x2q 414 15 to to IN cord-007796-zggk0x2q 414 16 the the DT cord-007796-zggk0x2q 414 17 surrounding surround VBG cord-007796-zggk0x2q 414 18 tissue tissue NN cord-007796-zggk0x2q 414 19 ( ( -LRB- cord-007796-zggk0x2q 414 20 Figure figure NN cord-007796-zggk0x2q 414 21 4.4 4.4 CD cord-007796-zggk0x2q 414 22 ) ) -RRB- cord-007796-zggk0x2q 414 23 . . . cord-007796-zggk0x2q 415 1 However however RB cord-007796-zggk0x2q 415 2 , , , cord-007796-zggk0x2q 415 3 several several JJ cord-007796-zggk0x2q 415 4 respiratory respiratory JJ cord-007796-zggk0x2q 415 5 viruses virus NNS cord-007796-zggk0x2q 415 6 have have VBP cord-007796-zggk0x2q 415 7 developed develop VBN cord-007796-zggk0x2q 415 8 mechanisms mechanism NNS cord-007796-zggk0x2q 415 9 to to TO cord-007796-zggk0x2q 415 10 inhibit inhibit VB cord-007796-zggk0x2q 415 11 apoptosis apoptosis NN cord-007796-zggk0x2q 415 12 . . . cord-007796-zggk0x2q 416 1 It -PRON- PRP cord-007796-zggk0x2q 416 2 has have VBZ cord-007796-zggk0x2q 416 3 been be VBN cord-007796-zggk0x2q 416 4 demonstrated demonstrate VBN cord-007796-zggk0x2q 416 5 that that IN cord-007796-zggk0x2q 416 6 RSV RSV NNP cord-007796-zggk0x2q 416 7 is be VBZ cord-007796-zggk0x2q 416 8 able able JJ cord-007796-zggk0x2q 416 9 to to TO cord-007796-zggk0x2q 416 10 effectively effectively RB cord-007796-zggk0x2q 416 11 inhibit inhibit VB cord-007796-zggk0x2q 416 12 apoptosis apoptosis NN cord-007796-zggk0x2q 416 13 of of IN cord-007796-zggk0x2q 416 14 epithelial epithelial JJ cord-007796-zggk0x2q 416 15 cells cell NNS cord-007796-zggk0x2q 416 16 in in IN cord-007796-zggk0x2q 416 17 vitro vitro FW cord-007796-zggk0x2q 416 18 , , , cord-007796-zggk0x2q 416 19 in in IN cord-007796-zggk0x2q 416 20 accordance accordance NN cord-007796-zggk0x2q 416 21 with with IN cord-007796-zggk0x2q 416 22 the the DT cord-007796-zggk0x2q 416 23 limited limited JJ cord-007796-zggk0x2q 416 24 pathology pathology NN cord-007796-zggk0x2q 416 25 induced induce VBN cord-007796-zggk0x2q 416 26 by by IN cord-007796-zggk0x2q 416 27 RSV RSV NNP cord-007796-zggk0x2q 416 28 in in IN cord-007796-zggk0x2q 416 29 epithelial epithelial JJ cord-007796-zggk0x2q 416 30 cells cell NNS cord-007796-zggk0x2q 416 31 during during IN cord-007796-zggk0x2q 416 32 the the DT cord-007796-zggk0x2q 416 33 first first JJ cord-007796-zggk0x2q 416 34 few few JJ cord-007796-zggk0x2q 416 35 days day NNS cord-007796-zggk0x2q 416 36 of of IN cord-007796-zggk0x2q 416 37 the the DT cord-007796-zggk0x2q 416 38 infection infection NN cord-007796-zggk0x2q 416 39 ( ( -LRB- cord-007796-zggk0x2q 416 40 Thomas Thomas NNP cord-007796-zggk0x2q 416 41 et et NNP cord-007796-zggk0x2q 416 42 al al NNP cord-007796-zggk0x2q 416 43 . . NNP cord-007796-zggk0x2q 416 44 , , , cord-007796-zggk0x2q 416 45 2002 2002 CD cord-007796-zggk0x2q 416 46 ) ) -RRB- cord-007796-zggk0x2q 416 47 . . . cord-007796-zggk0x2q 417 1 Eventually eventually RB cord-007796-zggk0x2q 417 2 , , , cord-007796-zggk0x2q 417 3 necrosis necrosis NN cord-007796-zggk0x2q 417 4 is be VBZ cord-007796-zggk0x2q 417 5 observed observe VBN cord-007796-zggk0x2q 417 6 when when WRB cord-007796-zggk0x2q 417 7 mature mature JJ cord-007796-zggk0x2q 417 8 viral viral JJ cord-007796-zggk0x2q 417 9 particles particle NNS cord-007796-zggk0x2q 417 10 are be VBP cord-007796-zggk0x2q 417 11 released release VBN cord-007796-zggk0x2q 417 12 from from IN cord-007796-zggk0x2q 417 13 the the DT cord-007796-zggk0x2q 417 14 cells cell NNS cord-007796-zggk0x2q 417 15 , , , cord-007796-zggk0x2q 417 16 after after IN cord-007796-zggk0x2q 417 17 2 2 CD cord-007796-zggk0x2q 417 18 - - SYM cord-007796-zggk0x2q 417 19 3 3 CD cord-007796-zggk0x2q 417 20 days day NNS cord-007796-zggk0x2q 417 21 . . . cord-007796-zggk0x2q 418 1 Furthermore furthermore RB cord-007796-zggk0x2q 418 2 , , , cord-007796-zggk0x2q 418 3 experiments experiment NNS cord-007796-zggk0x2q 418 4 with with IN cord-007796-zggk0x2q 418 5 both both DT cord-007796-zggk0x2q 418 6 adult adult NN cord-007796-zggk0x2q 418 7 and and CC cord-007796-zggk0x2q 418 8 cord cord NN cord-007796-zggk0x2q 418 9 blood blood NN cord-007796-zggk0x2q 418 10 monocytes monocyte NNS cord-007796-zggk0x2q 418 11 have have VBP cord-007796-zggk0x2q 418 12 shown show VBN cord-007796-zggk0x2q 418 13 a a DT cord-007796-zggk0x2q 418 14 prolonged prolonged JJ cord-007796-zggk0x2q 418 15 longevity longevity NN cord-007796-zggk0x2q 418 16 of of IN cord-007796-zggk0x2q 418 17 cells cell NNS cord-007796-zggk0x2q 418 18 , , , cord-007796-zggk0x2q 418 19 when when WRB cord-007796-zggk0x2q 418 20 cultured culture VBN cord-007796-zggk0x2q 418 21 in in IN cord-007796-zggk0x2q 418 22 the the DT cord-007796-zggk0x2q 418 23 presence presence NN cord-007796-zggk0x2q 418 24 of of IN cord-007796-zggk0x2q 418 25 RSV RSV NNP cord-007796-zggk0x2q 418 26 ( ( -LRB- cord-007796-zggk0x2q 418 27 Krilov Krilov NNP cord-007796-zggk0x2q 418 28 et et FW cord-007796-zggk0x2q 418 29 al al NNP cord-007796-zggk0x2q 418 30 . . NNP cord-007796-zggk0x2q 418 31 , , , cord-007796-zggk0x2q 418 32 2000 2000 CD cord-007796-zggk0x2q 418 33 ) ) -RRB- cord-007796-zggk0x2q 418 34 . . . cord-007796-zggk0x2q 419 1 Of of IN cord-007796-zggk0x2q 419 2 all all DT cord-007796-zggk0x2q 419 3 respiratory respiratory JJ cord-007796-zggk0x2q 419 4 viruses virus NNS cord-007796-zggk0x2q 419 5 , , , cord-007796-zggk0x2q 419 6 viral viral JJ cord-007796-zggk0x2q 419 7 evasion evasion NN cord-007796-zggk0x2q 419 8 techniques technique NNS cord-007796-zggk0x2q 419 9 of of IN cord-007796-zggk0x2q 419 10 adenoviruses adenovirus NNS cord-007796-zggk0x2q 419 11 have have VBP cord-007796-zggk0x2q 419 12 been be VBN cord-007796-zggk0x2q 419 13 studied study VBN cord-007796-zggk0x2q 419 14 most most RBS cord-007796-zggk0x2q 419 15 intensively intensively RB cord-007796-zggk0x2q 419 16 . . . cord-007796-zggk0x2q 420 1 It -PRON- PRP cord-007796-zggk0x2q 420 2 appears appear VBZ cord-007796-zggk0x2q 420 3 that that IN cord-007796-zggk0x2q 420 4 approximately approximately RB cord-007796-zggk0x2q 420 5 a a DT cord-007796-zggk0x2q 420 6 third third NN cord-007796-zggk0x2q 420 7 of of IN cord-007796-zggk0x2q 420 8 the the DT cord-007796-zggk0x2q 420 9 adenovirus adenovirus NN cord-007796-zggk0x2q 420 10 genome genome NN cord-007796-zggk0x2q 420 11 is be VBZ cord-007796-zggk0x2q 420 12 devoted devote VBN cord-007796-zggk0x2q 420 13 to to IN cord-007796-zggk0x2q 420 14 counteracting counteract VBG cord-007796-zggk0x2q 420 15 innate innate JJ cord-007796-zggk0x2q 420 16 and and CC cord-007796-zggk0x2q 420 17 adaptive adaptive JJ cord-007796-zggk0x2q 420 18 immune immune JJ cord-007796-zggk0x2q 420 19 defenses defense NNS cord-007796-zggk0x2q 421 1 ( ( -LRB- cord-007796-zggk0x2q 421 2 Burgert Burgert NNP cord-007796-zggk0x2q 421 3 et et NNP cord-007796-zggk0x2q 421 4 al al NNP cord-007796-zggk0x2q 421 5 . . NNP cord-007796-zggk0x2q 421 6 , , , cord-007796-zggk0x2q 421 7 2002 2002 CD cord-007796-zggk0x2q 421 8 ) ) -RRB- cord-007796-zggk0x2q 421 9 . . . cord-007796-zggk0x2q 422 1 Adenoviruses adenovirus NNS cord-007796-zggk0x2q 422 2 encode encode VBP cord-007796-zggk0x2q 422 3 the the DT cord-007796-zggk0x2q 422 4 protein protein NN cord-007796-zggk0x2q 422 5 E1A e1a NN cord-007796-zggk0x2q 422 6 that that WDT cord-007796-zggk0x2q 422 7 blocks block VBZ cord-007796-zggk0x2q 422 8 interferon interferon NN cord-007796-zggk0x2q 422 9 - - HYPH cord-007796-zggk0x2q 422 10 induced induce VBN cord-007796-zggk0x2q 422 11 gene gene NN cord-007796-zggk0x2q 422 12 transcription transcription NN cord-007796-zggk0x2q 422 13 . . . cord-007796-zggk0x2q 423 1 Through through IN cord-007796-zggk0x2q 423 2 the the DT cord-007796-zggk0x2q 423 3 VA VA NNP cord-007796-zggk0x2q 423 4 - - HYPH cord-007796-zggk0x2q 423 5 RNA RNA NNP cord-007796-zggk0x2q 423 6 protein protein NN cord-007796-zggk0x2q 423 7 that that WDT cord-007796-zggk0x2q 423 8 blocks block VBZ cord-007796-zggk0x2q 423 9 activation activation NN cord-007796-zggk0x2q 423 10 of of IN cord-007796-zggk0x2q 423 11 PKR PKR NNP cord-007796-zggk0x2q 423 12 , , , cord-007796-zggk0x2q 423 13 they -PRON- PRP cord-007796-zggk0x2q 423 14 also also RB cord-007796-zggk0x2q 423 15 interfere interfere VBP cord-007796-zggk0x2q 423 16 with with IN cord-007796-zggk0x2q 423 17 the the DT cord-007796-zggk0x2q 423 18 antiviral antiviral JJ cord-007796-zggk0x2q 423 19 enzymes enzyme NNS cord-007796-zggk0x2q 423 20 that that WDT cord-007796-zggk0x2q 423 21 are be VBP cord-007796-zggk0x2q 423 22 synthesized synthesize VBN cord-007796-zggk0x2q 423 23 under under IN cord-007796-zggk0x2q 423 24 interferon interferon NN cord-007796-zggk0x2q 423 25 control control NN cord-007796-zggk0x2q 423 26 . . . cord-007796-zggk0x2q 424 1 Additionally additionally RB cord-007796-zggk0x2q 424 2 , , , cord-007796-zggk0x2q 424 3 adenoviruses adenovirus NNS cord-007796-zggk0x2q 424 4 have have VBP cord-007796-zggk0x2q 424 5 developed develop VBN cord-007796-zggk0x2q 424 6 several several JJ cord-007796-zggk0x2q 424 7 mechanisms mechanism NNS cord-007796-zggk0x2q 424 8 to to TO cord-007796-zggk0x2q 424 9 inhibit inhibit VB cord-007796-zggk0x2q 424 10 both both DT cord-007796-zggk0x2q 424 11 constitutive constitutive JJ cord-007796-zggk0x2q 424 12 and and CC cord-007796-zggk0x2q 424 13 death death NN cord-007796-zggk0x2q 424 14 receptor receptor NN cord-007796-zggk0x2q 424 15 induced induce VBN cord-007796-zggk0x2q 424 16 apoptosis apoptosis NN cord-007796-zggk0x2q 424 17 ( ( -LRB- cord-007796-zggk0x2q 424 18 Figure figure NN cord-007796-zggk0x2q 424 19 4.4 4.4 CD cord-007796-zggk0x2q 424 20 ) ) -RRB- cord-007796-zggk0x2q 424 21 . . . cord-007796-zggk0x2q 425 1 The the DT cord-007796-zggk0x2q 425 2 E1B/55 E1B/55 NNP cord-007796-zggk0x2q 425 3 K K NNP cord-007796-zggk0x2q 425 4 protein protein NN cord-007796-zggk0x2q 425 5 inhibits inhibit VBZ cord-007796-zggk0x2q 425 6 p53-mediated p53-mediated JJ cord-007796-zggk0x2q 425 7 apoptosis apoptosis NN cord-007796-zggk0x2q 425 8 , , , cord-007796-zggk0x2q 425 9 E3/19 E3/19 NNP cord-007796-zggk0x2q 425 10 K K NNP cord-007796-zggk0x2q 425 11 interacts interact VBZ cord-007796-zggk0x2q 425 12 with with IN cord-007796-zggk0x2q 425 13 pro pro JJ cord-007796-zggk0x2q 425 14 - - JJ cord-007796-zggk0x2q 425 15 apoptotic apoptotic JJ cord-007796-zggk0x2q 425 16 proteins protein NNS cord-007796-zggk0x2q 426 1 Bax Bax NNP cord-007796-zggk0x2q 426 2 and and CC cord-007796-zggk0x2q 426 3 Bak Bak NNP cord-007796-zggk0x2q 426 4 , , , cord-007796-zggk0x2q 426 5 whereas whereas IN cord-007796-zggk0x2q 426 6 several several JJ cord-007796-zggk0x2q 426 7 E3 e3 NN cord-007796-zggk0x2q 426 8 proteins protein NNS cord-007796-zggk0x2q 426 9 are be VBP cord-007796-zggk0x2q 426 10 involved involve VBN cord-007796-zggk0x2q 426 11 in in IN cord-007796-zggk0x2q 426 12 removing remove VBG cord-007796-zggk0x2q 426 13 Fas Fas NNP cord-007796-zggk0x2q 426 14 and and CC cord-007796-zggk0x2q 426 15 Trail Trail NNP cord-007796-zggk0x2q 426 16 ( ( -LRB- cord-007796-zggk0x2q 426 17 death death NN cord-007796-zggk0x2q 426 18 ) ) -RRB- cord-007796-zggk0x2q 426 19 receptors receptor NNS cord-007796-zggk0x2q 426 20 from from IN cord-007796-zggk0x2q 426 21 the the DT cord-007796-zggk0x2q 426 22 cell cell NN cord-007796-zggk0x2q 426 23 surface surface NN cord-007796-zggk0x2q 426 24 by by IN cord-007796-zggk0x2q 426 25 promoting promote VBG cord-007796-zggk0x2q 426 26 their -PRON- PRP$ cord-007796-zggk0x2q 426 27 degradation degradation NN cord-007796-zggk0x2q 426 28 in in IN cord-007796-zggk0x2q 426 29 lysosomes lysosome NNS cord-007796-zggk0x2q 426 30 ( ( -LRB- cord-007796-zggk0x2q 426 31 Wold Wold NNP cord-007796-zggk0x2q 426 32 et et NNP cord-007796-zggk0x2q 426 33 al al NNP cord-007796-zggk0x2q 426 34 . . NNP cord-007796-zggk0x2q 426 35 , , , cord-007796-zggk0x2q 426 36 1999 1999 CD cord-007796-zggk0x2q 426 37 ) ) -RRB- cord-007796-zggk0x2q 426 38 . . . cord-007796-zggk0x2q 427 1 Finally finally RB cord-007796-zggk0x2q 427 2 , , , cord-007796-zggk0x2q 427 3 adenoviruses adenovirus NNS cord-007796-zggk0x2q 427 4 interfere interfere VBP cord-007796-zggk0x2q 427 5 with with IN cord-007796-zggk0x2q 427 6 recognition recognition NN cord-007796-zggk0x2q 427 7 of of IN cord-007796-zggk0x2q 427 8 infected infected JJ cord-007796-zggk0x2q 427 9 cells cell NNS cord-007796-zggk0x2q 427 10 by by IN cord-007796-zggk0x2q 427 11 cytotoxic cytotoxic JJ cord-007796-zggk0x2q 427 12 lymphocytes lymphocyte NNS cord-007796-zggk0x2q 427 13 . . . cord-007796-zggk0x2q 428 1 The the DT cord-007796-zggk0x2q 428 2 adenovirus adenovirus NN cord-007796-zggk0x2q 429 1 E3/19 e3/19 NN cord-007796-zggk0x2q 429 2 K K NNP cord-007796-zggk0x2q 429 3 protein protein NN cord-007796-zggk0x2q 429 4 inhibits inhibit VBZ cord-007796-zggk0x2q 429 5 transport transport NN cord-007796-zggk0x2q 429 6 of of IN cord-007796-zggk0x2q 429 7 MHC1 MHC1 NNP cord-007796-zggk0x2q 429 8 molecules molecule NNS cord-007796-zggk0x2q 429 9 to to IN cord-007796-zggk0x2q 429 10 the the DT cord-007796-zggk0x2q 429 11 cell cell NN cord-007796-zggk0x2q 429 12 surface surface NN cord-007796-zggk0x2q 429 13 , , , cord-007796-zggk0x2q 429 14 resulting result VBG cord-007796-zggk0x2q 429 15 in in IN cord-007796-zggk0x2q 429 16 decreased decrease VBN cord-007796-zggk0x2q 429 17 viral viral JJ cord-007796-zggk0x2q 429 18 antigen antigen NN cord-007796-zggk0x2q 429 19 presentation presentation NN cord-007796-zggk0x2q 429 20 to to IN cord-007796-zggk0x2q 429 21 CD8ϩ CD8ϩ NNP cord-007796-zggk0x2q 429 22 cells cell NNS cord-007796-zggk0x2q 429 23 . . . cord-007796-zggk0x2q 430 1 Future future JJ cord-007796-zggk0x2q 430 2 studies study NNS cord-007796-zggk0x2q 430 3 may may MD cord-007796-zggk0x2q 430 4 unravel unravel VB cord-007796-zggk0x2q 430 5 further further JJ cord-007796-zggk0x2q 430 6 mechanisms mechanism NNS cord-007796-zggk0x2q 430 7 of of IN cord-007796-zggk0x2q 430 8 immune immune JJ cord-007796-zggk0x2q 430 9 evasion evasion NN cord-007796-zggk0x2q 430 10 that that WDT cord-007796-zggk0x2q 430 11 may may MD cord-007796-zggk0x2q 430 12 also also RB cord-007796-zggk0x2q 430 13 be be VB cord-007796-zggk0x2q 430 14 important important JJ cord-007796-zggk0x2q 430 15 in in IN cord-007796-zggk0x2q 430 16 viruses virus NNS cord-007796-zggk0x2q 430 17 involved involve VBN cord-007796-zggk0x2q 430 18 in in IN cord-007796-zggk0x2q 430 19 lower low JJR cord-007796-zggk0x2q 430 20 respiratory respiratory JJ cord-007796-zggk0x2q 430 21 tract tract NN cord-007796-zggk0x2q 430 22 disease disease NN cord-007796-zggk0x2q 430 23 . . . cord-007796-zggk0x2q 431 1 This this DT cord-007796-zggk0x2q 431 2 knowledge knowledge NN cord-007796-zggk0x2q 431 3 Extrinsic extrinsic JJ cord-007796-zggk0x2q 431 4 and and CC cord-007796-zggk0x2q 431 5 intrinsic intrinsic JJ cord-007796-zggk0x2q 431 6 signaling signal VBG cord-007796-zggk0x2q 431 7 pathways pathway NNS cord-007796-zggk0x2q 431 8 of of IN cord-007796-zggk0x2q 431 9 apoptosis apoptosis NN cord-007796-zggk0x2q 431 10 . . . cord-007796-zggk0x2q 432 1 Some some DT cord-007796-zggk0x2q 432 2 viruses virus NNS cord-007796-zggk0x2q 432 3 such such JJ cord-007796-zggk0x2q 432 4 as as IN cord-007796-zggk0x2q 432 5 adenovirus adenovirus NN cord-007796-zggk0x2q 432 6 interfere interfere VBP cord-007796-zggk0x2q 432 7 with with IN cord-007796-zggk0x2q 432 8 cellular cellular JJ cord-007796-zggk0x2q 432 9 apoptosis apoptosis NN cord-007796-zggk0x2q 432 10 . . . cord-007796-zggk0x2q 433 1 Cellular cellular JJ cord-007796-zggk0x2q 433 2 apoptosis apoptosis NN cord-007796-zggk0x2q 433 3 can can MD cord-007796-zggk0x2q 433 4 normally normally RB cord-007796-zggk0x2q 433 5 occur occur VB cord-007796-zggk0x2q 433 6 via via IN cord-007796-zggk0x2q 433 7 activation activation NN cord-007796-zggk0x2q 433 8 of of IN cord-007796-zggk0x2q 433 9 the the DT cord-007796-zggk0x2q 433 10 extrinsic extrinsic JJ cord-007796-zggk0x2q 433 11 ( ( -LRB- cord-007796-zggk0x2q 433 12 death death NN cord-007796-zggk0x2q 433 13 receptor receptor NN cord-007796-zggk0x2q 433 14 ) ) -RRB- cord-007796-zggk0x2q 433 15 pathway pathway NN cord-007796-zggk0x2q 433 16 or or CC cord-007796-zggk0x2q 433 17 the the DT cord-007796-zggk0x2q 433 18 intrinsic intrinsic JJ cord-007796-zggk0x2q 433 19 pathway pathway NN cord-007796-zggk0x2q 433 20 . . . cord-007796-zggk0x2q 434 1 Both both DT cord-007796-zggk0x2q 434 2 lead lead NN cord-007796-zggk0x2q 434 3 to to IN cord-007796-zggk0x2q 434 4 activation activation NN cord-007796-zggk0x2q 434 5 of of IN cord-007796-zggk0x2q 434 6 effector effector NN cord-007796-zggk0x2q 434 7 caspases caspase NNS cord-007796-zggk0x2q 434 8 3 3 CD cord-007796-zggk0x2q 434 9 and and CC cord-007796-zggk0x2q 434 10 7 7 CD cord-007796-zggk0x2q 434 11 , , , cord-007796-zggk0x2q 434 12 which which WDT cord-007796-zggk0x2q 434 13 will will MD cord-007796-zggk0x2q 434 14 inevitably inevitably RB cord-007796-zggk0x2q 434 15 result result VB cord-007796-zggk0x2q 434 16 in in IN cord-007796-zggk0x2q 434 17 apoptosis apoptosis NN cord-007796-zggk0x2q 434 18 . . . cord-007796-zggk0x2q 435 1 Via via IN cord-007796-zggk0x2q 435 2 production production NN cord-007796-zggk0x2q 435 3 of of IN cord-007796-zggk0x2q 435 4 external external JJ cord-007796-zggk0x2q 435 5 factors factor NNS cord-007796-zggk0x2q 435 6 , , , cord-007796-zggk0x2q 435 7 such such JJ cord-007796-zggk0x2q 435 8 as as IN cord-007796-zggk0x2q 435 9 TNF- TNF- NNP cord-007796-zggk0x2q 435 10 ␣ ␣ NNP cord-007796-zggk0x2q 435 11 , , , cord-007796-zggk0x2q 435 12 Fas Fas NNP cord-007796-zggk0x2q 435 13 - - HYPH cord-007796-zggk0x2q 435 14 Ligand Ligand NNP cord-007796-zggk0x2q 435 15 , , , cord-007796-zggk0x2q 435 16 and and CC cord-007796-zggk0x2q 435 17 Trail Trail NNP cord-007796-zggk0x2q 435 18 , , , cord-007796-zggk0x2q 435 19 death death NN cord-007796-zggk0x2q 435 20 - - HYPH cord-007796-zggk0x2q 435 21 receptors receptor NNS cord-007796-zggk0x2q 435 22 are be VBP cord-007796-zggk0x2q 435 23 cross cross JJ cord-007796-zggk0x2q 435 24 - - JJ cord-007796-zggk0x2q 435 25 linked link VBN cord-007796-zggk0x2q 435 26 , , , cord-007796-zggk0x2q 435 27 which which WDT cord-007796-zggk0x2q 435 28 leads lead VBZ cord-007796-zggk0x2q 435 29 to to IN cord-007796-zggk0x2q 435 30 apoptosis apoptosis NN cord-007796-zggk0x2q 435 31 . . . cord-007796-zggk0x2q 436 1 Adenovirus Adenovirus NNP cord-007796-zggk0x2q 436 2 E3 E3 NNP cord-007796-zggk0x2q 436 3 proteins protein NNS cord-007796-zggk0x2q 436 4 can can MD cord-007796-zggk0x2q 436 5 remove remove VB cord-007796-zggk0x2q 436 6 these these DT cord-007796-zggk0x2q 436 7 death death NN cord-007796-zggk0x2q 436 8 receptors receptor NNS cord-007796-zggk0x2q 436 9 from from IN cord-007796-zggk0x2q 436 10 the the DT cord-007796-zggk0x2q 436 11 surface surface NN cord-007796-zggk0x2q 436 12 , , , cord-007796-zggk0x2q 436 13 thereby thereby RB cord-007796-zggk0x2q 436 14 inhibiting inhibit VBG cord-007796-zggk0x2q 436 15 extrinsic extrinsic JJ cord-007796-zggk0x2q 436 16 apoptosis apoptosis NN cord-007796-zggk0x2q 436 17 . . . cord-007796-zggk0x2q 437 1 The the DT cord-007796-zggk0x2q 437 2 intrinsic intrinsic JJ cord-007796-zggk0x2q 437 3 pathway pathway NN cord-007796-zggk0x2q 437 4 is be VBZ cord-007796-zggk0x2q 437 5 regulated regulate VBN cord-007796-zggk0x2q 437 6 by by IN cord-007796-zggk0x2q 437 7 pro pro JJ cord-007796-zggk0x2q 437 8 - - JJ cord-007796-zggk0x2q 437 9 and and CC cord-007796-zggk0x2q 437 10 anti anti JJ cord-007796-zggk0x2q 437 11 - - JJ cord-007796-zggk0x2q 437 12 apoptotic apoptotic JJ cord-007796-zggk0x2q 437 13 proteins protein NNS cord-007796-zggk0x2q 437 14 of of IN cord-007796-zggk0x2q 437 15 the the DT cord-007796-zggk0x2q 437 16 Bcl2-family Bcl2-family NNP cord-007796-zggk0x2q 437 17 . . . cord-007796-zggk0x2q 438 1 The the DT cord-007796-zggk0x2q 438 2 transcription transcription NN cord-007796-zggk0x2q 438 3 factor factor NN cord-007796-zggk0x2q 438 4 p53 p53 NN cord-007796-zggk0x2q 438 5 has have VBZ cord-007796-zggk0x2q 438 6 anticarcinogenic anticarcinogenic JJ cord-007796-zggk0x2q 438 7 activity activity NN cord-007796-zggk0x2q 438 8 , , , cord-007796-zggk0x2q 438 9 induces induce VBZ cord-007796-zggk0x2q 438 10 the the DT cord-007796-zggk0x2q 438 11 intrinsic intrinsic JJ cord-007796-zggk0x2q 438 12 pathway pathway NN cord-007796-zggk0x2q 438 13 and and CC cord-007796-zggk0x2q 438 14 promotes promote VBZ cord-007796-zggk0x2q 438 15 the the DT cord-007796-zggk0x2q 438 16 transcription transcription NN cord-007796-zggk0x2q 438 17 of of IN cord-007796-zggk0x2q 438 18 pro pro JJ cord-007796-zggk0x2q 438 19 - - JJ cord-007796-zggk0x2q 438 20 apoptotic apoptotic JJ cord-007796-zggk0x2q 438 21 proteins protein NNS cord-007796-zggk0x2q 438 22 such such JJ cord-007796-zggk0x2q 438 23 as as IN cord-007796-zggk0x2q 438 24 Bax Bax NNP cord-007796-zggk0x2q 438 25 and and CC cord-007796-zggk0x2q 438 26 Bak Bak NNP cord-007796-zggk0x2q 438 27 . . . cord-007796-zggk0x2q 439 1 These these DT cord-007796-zggk0x2q 439 2 proteins protein NNS cord-007796-zggk0x2q 439 3 induce induce VBP cord-007796-zggk0x2q 439 4 mitochondrial mitochondrial JJ cord-007796-zggk0x2q 439 5 leakage leakage NN cord-007796-zggk0x2q 439 6 of of IN cord-007796-zggk0x2q 439 7 cytochrome cytochrome NN cord-007796-zggk0x2q 439 8 c c NN cord-007796-zggk0x2q 439 9 , , , cord-007796-zggk0x2q 439 10 which which WDT cord-007796-zggk0x2q 439 11 activates activate VBZ cord-007796-zggk0x2q 439 12 caspase caspase NN cord-007796-zggk0x2q 439 13 9 9 CD cord-007796-zggk0x2q 439 14 , , , cord-007796-zggk0x2q 439 15 finally finally RB cord-007796-zggk0x2q 439 16 leading lead VBG cord-007796-zggk0x2q 439 17 to to IN cord-007796-zggk0x2q 439 18 effector effector VB cord-007796-zggk0x2q 439 19 caspase caspase NN cord-007796-zggk0x2q 439 20 activation activation NN cord-007796-zggk0x2q 439 21 and and CC cord-007796-zggk0x2q 439 22 apoptosis apoptosis NN cord-007796-zggk0x2q 439 23 . . . cord-007796-zggk0x2q 440 1 Adenovirus Adenovirus NNP cord-007796-zggk0x2q 440 2 proteins protein NNS cord-007796-zggk0x2q 440 3 are be VBP cord-007796-zggk0x2q 440 4 involved involve VBN cord-007796-zggk0x2q 440 5 in in IN cord-007796-zggk0x2q 440 6 both both DT cord-007796-zggk0x2q 440 7 inhibition inhibition NN cord-007796-zggk0x2q 440 8 of of IN cord-007796-zggk0x2q 440 9 p53 p53 NN cord-007796-zggk0x2q 440 10 and and CC cord-007796-zggk0x2q 440 11 the the DT cord-007796-zggk0x2q 440 12 functioning functioning NN cord-007796-zggk0x2q 440 13 of of IN cord-007796-zggk0x2q 440 14 Bax Bax NNP cord-007796-zggk0x2q 440 15 and and CC cord-007796-zggk0x2q 440 16 Bak Bak NNP cord-007796-zggk0x2q 440 17 . . . cord-007796-zggk0x2q 441 1 An an DT cord-007796-zggk0x2q 441 2 outbreak outbreak NN cord-007796-zggk0x2q 441 3 of of IN cord-007796-zggk0x2q 441 4 respiratory respiratory JJ cord-007796-zggk0x2q 441 5 syncytial syncytial JJ cord-007796-zggk0x2q 441 6 virus virus NN cord-007796-zggk0x2q 441 7 infection infection NN cord-007796-zggk0x2q 441 8 in in IN cord-007796-zggk0x2q 441 9 a a DT cord-007796-zggk0x2q 441 10 bone bone NN cord-007796-zggk0x2q 441 11 marrow marrow NN cord-007796-zggk0x2q 441 12 transplant transplant NN cord-007796-zggk0x2q 441 13 unit unit NN cord-007796-zggk0x2q 441 14 : : : cord-007796-zggk0x2q 441 15 Effect effect VB cord-007796-zggk0x2q 441 16 on on IN cord-007796-zggk0x2q 441 17 engraftment engraftment NN cord-007796-zggk0x2q 441 18 and and CC cord-007796-zggk0x2q 441 19 outcome outcome NN cord-007796-zggk0x2q 441 20 of of IN cord-007796-zggk0x2q 441 21 pneumonia pneumonia NN cord-007796-zggk0x2q 441 22 without without IN cord-007796-zggk0x2q 441 23 specific specific JJ cord-007796-zggk0x2q 441 24 antiviral antiviral JJ cord-007796-zggk0x2q 441 25 treatment treatment NN cord-007796-zggk0x2q 441 26 Recognition Recognition NNP cord-007796-zggk0x2q 441 27 of of IN cord-007796-zggk0x2q 441 28 pathogen pathogen NN cord-007796-zggk0x2q 441 29 - - HYPH cord-007796-zggk0x2q 441 30 associated associate VBN cord-007796-zggk0x2q 441 31 molecular molecular JJ cord-007796-zggk0x2q 441 32 patterns pattern NNS cord-007796-zggk0x2q 441 33 by by IN cord-007796-zggk0x2q 441 34 TLR TLR NNP cord-007796-zggk0x2q 441 35 family family NN cord-007796-zggk0x2q 441 36 Essential essential JJ cord-007796-zggk0x2q 441 37 role role NN cord-007796-zggk0x2q 441 38 for for IN cord-007796-zggk0x2q 441 39 the the DT cord-007796-zggk0x2q 441 40 dsRNA dsrna JJ cord-007796-zggk0x2q 441 41 - - HYPH cord-007796-zggk0x2q 441 42 dependent dependent JJ cord-007796-zggk0x2q 441 43 protein protein NN cord-007796-zggk0x2q 441 44 kinase kinase VBZ cord-007796-zggk0x2q 441 45 PKR PKR NNP cord-007796-zggk0x2q 441 46 in in IN cord-007796-zggk0x2q 441 47 innate innate JJ cord-007796-zggk0x2q 441 48 immunity immunity NN cord-007796-zggk0x2q 441 49 to to IN cord-007796-zggk0x2q 441 50 viral viral JJ cord-007796-zggk0x2q 441 51 infection infection NN cord-007796-zggk0x2q 441 52 Human human JJ cord-007796-zggk0x2q 441 53 and and CC cord-007796-zggk0x2q 441 54 murine murine JJ cord-007796-zggk0x2q 441 55 cytotoxic cytotoxic JJ cord-007796-zggk0x2q 441 56 T t NN cord-007796-zggk0x2q 441 57 cells cell NNS cord-007796-zggk0x2q 441 58 specific specific JJ cord-007796-zggk0x2q 441 59 to to IN cord-007796-zggk0x2q 441 60 respiratory respiratory JJ cord-007796-zggk0x2q 441 61 syncytial syncytial JJ cord-007796-zggk0x2q 441 62 virus virus NN cord-007796-zggk0x2q 441 63 recognize recognize VBP cord-007796-zggk0x2q 441 64 the the DT cord-007796-zggk0x2q 441 65 viral viral JJ cord-007796-zggk0x2q 441 66 nucleoprotein nucleoprotein NNP cord-007796-zggk0x2q 441 67 ( ( -LRB- cord-007796-zggk0x2q 441 68 N N NNP cord-007796-zggk0x2q 441 69 ) ) -RRB- cord-007796-zggk0x2q 441 70 , , , cord-007796-zggk0x2q 441 71 but but CC cord-007796-zggk0x2q 441 72 not not RB cord-007796-zggk0x2q 441 73 the the DT cord-007796-zggk0x2q 441 74 major major JJ cord-007796-zggk0x2q 441 75 glycoprotein glycoprotein NN cord-007796-zggk0x2q 441 76 ( ( -LRB- cord-007796-zggk0x2q 441 77 G G NNP cord-007796-zggk0x2q 441 78 ) ) -RRB- cord-007796-zggk0x2q 441 79 , , , cord-007796-zggk0x2q 441 80 expressed express VBN cord-007796-zggk0x2q 441 81 by by IN cord-007796-zggk0x2q 441 82 vaccinia vaccinia NN cord-007796-zggk0x2q 441 83 virus virus NN cord-007796-zggk0x2q 441 84 recombinants recombinant NNS cord-007796-zggk0x2q 441 85 Viruses virus NNS cord-007796-zggk0x2q 441 86 as as IN cord-007796-zggk0x2q 441 87 precipitants precipitant NNS cord-007796-zggk0x2q 441 88 of of IN cord-007796-zggk0x2q 441 89 asthma asthma NN cord-007796-zggk0x2q 441 90 symptoms symptom NNS cord-007796-zggk0x2q 441 91 . . . cord-007796-zggk0x2q 442 1 II II NNP cord-007796-zggk0x2q 442 2 . . . cord-007796-zggk0x2q 443 1 Physiology physiology NN cord-007796-zggk0x2q 443 2 and and CC cord-007796-zggk0x2q 443 3 mechanisms mechanism NNS cord-007796-zggk0x2q 443 4 Transcriptional Transcriptional NNP cord-007796-zggk0x2q 443 5 induction induction NN cord-007796-zggk0x2q 443 6 of of IN cord-007796-zggk0x2q 443 7 multiple multiple JJ cord-007796-zggk0x2q 443 8 cytokines cytokine NNS cord-007796-zggk0x2q 443 9 by by IN cord-007796-zggk0x2q 443 10 human human JJ cord-007796-zggk0x2q 443 11 respiratory respiratory JJ cord-007796-zggk0x2q 443 12 syncytial syncytial JJ cord-007796-zggk0x2q 443 13 virus virus NN cord-007796-zggk0x2q 443 14 requires require VBZ cord-007796-zggk0x2q 443 15 activation activation NN cord-007796-zggk0x2q 443 16 of of IN cord-007796-zggk0x2q 443 17 NF nf NN cord-007796-zggk0x2q 443 18 - - HYPH cord-007796-zggk0x2q 443 19 kappa kappa NN cord-007796-zggk0x2q 443 20 B b NN cord-007796-zggk0x2q 443 21 and and CC cord-007796-zggk0x2q 443 22 is be VBZ cord-007796-zggk0x2q 443 23 inhibited inhibit VBN cord-007796-zggk0x2q 443 24 by by IN cord-007796-zggk0x2q 443 25 sodium sodium NN cord-007796-zggk0x2q 443 26 salicylate salicylate NN cord-007796-zggk0x2q 443 27 and and CC cord-007796-zggk0x2q 443 28 aspirin aspirin NN cord-007796-zggk0x2q 443 29 Bacteraemia Bacteraemia NNP cord-007796-zggk0x2q 443 30 and and CC cord-007796-zggk0x2q 443 31 antibiotic antibiotic JJ cord-007796-zggk0x2q 443 32 use use NN cord-007796-zggk0x2q 443 33 in in IN cord-007796-zggk0x2q 443 34 respiratory respiratory JJ cord-007796-zggk0x2q 443 35 syncytial syncytial JJ cord-007796-zggk0x2q 443 36 virus virus NN cord-007796-zggk0x2q 443 37 infections infection NNS cord-007796-zggk0x2q 443 38 Long long JJ cord-007796-zggk0x2q 443 39 - - HYPH cord-007796-zggk0x2q 443 40 term term NN cord-007796-zggk0x2q 443 41 consequences consequence NNS cord-007796-zggk0x2q 443 42 of of IN cord-007796-zggk0x2q 443 43 respiratory respiratory JJ cord-007796-zggk0x2q 443 44 syncytial syncytial JJ cord-007796-zggk0x2q 443 45 virus virus NN cord-007796-zggk0x2q 443 46 ( ( -LRB- cord-007796-zggk0x2q 443 47 RSV RSV NNP cord-007796-zggk0x2q 443 48 ) ) -RRB- cord-007796-zggk0x2q 443 49 bronchiolitis bronchioliti VBD cord-007796-zggk0x2q 443 50 Peripheral peripheral JJ cord-007796-zggk0x2q 443 51 blood blood NN cord-007796-zggk0x2q 443 52 cytokine cytokine NN cord-007796-zggk0x2q 443 53 responses response NNS cord-007796-zggk0x2q 443 54 and and CC cord-007796-zggk0x2q 443 55 disease disease NN cord-007796-zggk0x2q 443 56 severity severity NN cord-007796-zggk0x2q 443 57 in in IN cord-007796-zggk0x2q 443 58 respiratory respiratory JJ cord-007796-zggk0x2q 443 59 syncytial syncytial JJ cord-007796-zggk0x2q 443 60 virus virus NN cord-007796-zggk0x2q 443 61 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 443 62 Immunological immunological JJ cord-007796-zggk0x2q 443 63 mechanisms mechanism NNS cord-007796-zggk0x2q 443 64 of of IN cord-007796-zggk0x2q 443 65 severe severe JJ cord-007796-zggk0x2q 443 66 respiratory respiratory JJ cord-007796-zggk0x2q 443 67 syncytial syncytial JJ cord-007796-zggk0x2q 443 68 virus virus NN cord-007796-zggk0x2q 443 69 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 443 70 Seasonality Seasonality NNP cord-007796-zggk0x2q 443 71 of of IN cord-007796-zggk0x2q 443 72 long long JJ cord-007796-zggk0x2q 443 73 term term NN cord-007796-zggk0x2q 443 74 wheezing wheeze VBG cord-007796-zggk0x2q 443 75 following follow VBG cord-007796-zggk0x2q 443 76 respiratory respiratory JJ cord-007796-zggk0x2q 443 77 syncytial syncytial JJ cord-007796-zggk0x2q 443 78 virus virus NN cord-007796-zggk0x2q 443 79 lower low JJR cord-007796-zggk0x2q 443 80 respiratory respiratory JJ cord-007796-zggk0x2q 443 81 tract tract NN cord-007796-zggk0x2q 443 82 infection infection NN cord-007796-zggk0x2q 443 83 Natural natural JJ cord-007796-zggk0x2q 443 84 reinfection reinfection NN cord-007796-zggk0x2q 443 85 with with IN cord-007796-zggk0x2q 443 86 respiratory respiratory JJ cord-007796-zggk0x2q 443 87 syncytial syncytial JJ cord-007796-zggk0x2q 443 88 virus virus NN cord-007796-zggk0x2q 443 89 does do VBZ cord-007796-zggk0x2q 443 90 not not RB cord-007796-zggk0x2q 443 91 boost boost VB cord-007796-zggk0x2q 443 92 virus virus NN cord-007796-zggk0x2q 443 93 - - HYPH cord-007796-zggk0x2q 443 94 specific specific JJ cord-007796-zggk0x2q 443 95 T t NN cord-007796-zggk0x2q 443 96 - - HYPH cord-007796-zggk0x2q 443 97 cell cell NN cord-007796-zggk0x2q 443 98 immunity immunity NN cord-007796-zggk0x2q 443 99 Temporal temporal JJ cord-007796-zggk0x2q 443 100 activation activation NN cord-007796-zggk0x2q 443 101 of of IN cord-007796-zggk0x2q 443 102 NF NF NNP cord-007796-zggk0x2q 443 103 - - HYPH cord-007796-zggk0x2q 443 104 kappaB kappaB NNP cord-007796-zggk0x2q 443 105 regulates regulate VBZ cord-007796-zggk0x2q 443 106 an an DT cord-007796-zggk0x2q 443 107 interferon interferon NN cord-007796-zggk0x2q 443 108 - - HYPH cord-007796-zggk0x2q 443 109 independent independent JJ cord-007796-zggk0x2q 443 110 innate innate JJ cord-007796-zggk0x2q 443 111 antiviral antiviral JJ cord-007796-zggk0x2q 443 112 response response NN cord-007796-zggk0x2q 443 113 against against IN cord-007796-zggk0x2q 443 114 cytoplasmic cytoplasmic JJ cord-007796-zggk0x2q 443 115 RNA RNA NNP cord-007796-zggk0x2q 443 116 viruses virus NNS cord-007796-zggk0x2q 443 117 Subversion Subversion NNP cord-007796-zggk0x2q 443 118 of of IN cord-007796-zggk0x2q 443 119 host host NN cord-007796-zggk0x2q 443 120 defense defense NN cord-007796-zggk0x2q 443 121 mechanisms mechanism NNS cord-007796-zggk0x2q 443 122 by by IN cord-007796-zggk0x2q 443 123 adenoviruses adenovirus NNS cord-007796-zggk0x2q 443 124 Adenovirus Adenovirus NNP cord-007796-zggk0x2q 443 125 type type NN cord-007796-zggk0x2q 443 126 7 7 CD cord-007796-zggk0x2q 443 127 associated associate VBN cord-007796-zggk0x2q 443 128 with with IN cord-007796-zggk0x2q 443 129 severe severe JJ cord-007796-zggk0x2q 443 130 and and CC cord-007796-zggk0x2q 443 131 fatal fatal JJ cord-007796-zggk0x2q 443 132 acute acute JJ cord-007796-zggk0x2q 443 133 lower low JJR cord-007796-zggk0x2q 443 134 respiratory respiratory JJ cord-007796-zggk0x2q 443 135 infections infection NNS cord-007796-zggk0x2q 443 136 in in IN cord-007796-zggk0x2q 443 137 Argentine argentine JJ cord-007796-zggk0x2q 443 138 children child NNS cord-007796-zggk0x2q 444 1 A a DT cord-007796-zggk0x2q 444 2 comparison comparison NN cord-007796-zggk0x2q 444 3 of of IN cord-007796-zggk0x2q 444 4 nebulized nebulize VBN cord-007796-zggk0x2q 444 5 budesonide budesonide NNP cord-007796-zggk0x2q 444 6 , , , cord-007796-zggk0x2q 444 7 and and CC cord-007796-zggk0x2q 444 8 intramuscular intramuscular JJ cord-007796-zggk0x2q 444 9 , , , cord-007796-zggk0x2q 444 10 and and CC cord-007796-zggk0x2q 444 11 oral oral JJ cord-007796-zggk0x2q 444 12 dexamethasone dexamethasone NN cord-007796-zggk0x2q 444 13 for for IN cord-007796-zggk0x2q 444 14 treatment treatment NN cord-007796-zggk0x2q 444 15 of of IN cord-007796-zggk0x2q 444 16 croup croup NN cord-007796-zggk0x2q 445 1 A a DT cord-007796-zggk0x2q 445 2 common common JJ cord-007796-zggk0x2q 445 3 haplotype haplotype NN cord-007796-zggk0x2q 445 4 of of IN cord-007796-zggk0x2q 445 5 interleukin-4 interleukin-4 NNP cord-007796-zggk0x2q 445 6 gene gene NN cord-007796-zggk0x2q 445 7 IL4 IL4 NNP cord-007796-zggk0x2q 445 8 is be VBZ cord-007796-zggk0x2q 445 9 associated associate VBN cord-007796-zggk0x2q 445 10 with with IN cord-007796-zggk0x2q 445 11 severe severe JJ cord-007796-zggk0x2q 445 12 respiratory respiratory JJ cord-007796-zggk0x2q 445 13 syncytial syncytial JJ cord-007796-zggk0x2q 445 14 virus virus NN cord-007796-zggk0x2q 445 15 disease disease NN cord-007796-zggk0x2q 445 16 in in IN cord-007796-zggk0x2q 445 17 Korean korean JJ cord-007796-zggk0x2q 445 18 children child NNS cord-007796-zggk0x2q 445 19 Persistence persistence NN cord-007796-zggk0x2q 445 20 of of IN cord-007796-zggk0x2q 445 21 respiratory respiratory JJ cord-007796-zggk0x2q 445 22 syncytial syncytial JJ cord-007796-zggk0x2q 445 23 virus virus NN cord-007796-zggk0x2q 445 24 ( ( -LRB- cord-007796-zggk0x2q 445 25 RSV RSV NNP cord-007796-zggk0x2q 445 26 ) ) -RRB- cord-007796-zggk0x2q 445 27 infection infection NN cord-007796-zggk0x2q 445 28 and and CC cord-007796-zggk0x2q 445 29 development development NN cord-007796-zggk0x2q 445 30 of of IN cord-007796-zggk0x2q 445 31 RSV RSV NNP cord-007796-zggk0x2q 445 32 - - HYPH cord-007796-zggk0x2q 445 33 specific specific JJ cord-007796-zggk0x2q 445 34 IgG1 igg1 CD cord-007796-zggk0x2q 445 35 response response NN cord-007796-zggk0x2q 445 36 in in IN cord-007796-zggk0x2q 445 37 a a DT cord-007796-zggk0x2q 445 38 guinea guinea NN cord-007796-zggk0x2q 445 39 - - HYPH cord-007796-zggk0x2q 445 40 pig pig NN cord-007796-zggk0x2q 445 41 model model NN cord-007796-zggk0x2q 445 42 of of IN cord-007796-zggk0x2q 445 43 acute acute JJ cord-007796-zggk0x2q 445 44 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 445 45 Eosinophil eosinophil JJ cord-007796-zggk0x2q 445 46 activation activation NN cord-007796-zggk0x2q 445 47 and and CC cord-007796-zggk0x2q 445 48 cysteinyl cysteinyl NNP cord-007796-zggk0x2q 445 49 leukotriene leukotriene NN cord-007796-zggk0x2q 445 50 production production NN cord-007796-zggk0x2q 445 51 in in IN cord-007796-zggk0x2q 445 52 infants infant NNS cord-007796-zggk0x2q 445 53 with with IN cord-007796-zggk0x2q 445 54 respiratory respiratory JJ cord-007796-zggk0x2q 445 55 syncytial syncytial JJ cord-007796-zggk0x2q 445 56 virus virus NN cord-007796-zggk0x2q 445 57 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 445 58 Viral viral JJ cord-007796-zggk0x2q 445 59 infections infection NNS cord-007796-zggk0x2q 445 60 in in IN cord-007796-zggk0x2q 445 61 interferon interferon NN cord-007796-zggk0x2q 445 62 - - HYPH cord-007796-zggk0x2q 445 63 gamma gamma NN cord-007796-zggk0x2q 445 64 receptor receptor NN cord-007796-zggk0x2q 445 65 deficiency deficiency NN cord-007796-zggk0x2q 445 66 Human Human NNP cord-007796-zggk0x2q 445 67 metapneumovirus metapneumovirus JJ cord-007796-zggk0x2q 445 68 infection infection NN cord-007796-zggk0x2q 445 69 in in IN cord-007796-zggk0x2q 445 70 Japanese japanese JJ cord-007796-zggk0x2q 445 71 children child NNS cord-007796-zggk0x2q 445 72 Analysis Analysis NNP cord-007796-zggk0x2q 445 73 of of IN cord-007796-zggk0x2q 445 74 cells cell NNS cord-007796-zggk0x2q 445 75 obtained obtain VBN cord-007796-zggk0x2q 445 76 by by IN cord-007796-zggk0x2q 445 77 bronchial bronchial JJ cord-007796-zggk0x2q 445 78 lavage lavage NN cord-007796-zggk0x2q 445 79 of of IN cord-007796-zggk0x2q 445 80 infants infant NNS cord-007796-zggk0x2q 445 81 with with IN cord-007796-zggk0x2q 445 82 respiratory respiratory JJ cord-007796-zggk0x2q 445 83 syncytial syncytial JJ cord-007796-zggk0x2q 445 84 virus virus NN cord-007796-zggk0x2q 445 85 infection infection NN cord-007796-zggk0x2q 445 86 Eosinophil eosinophil JJ cord-007796-zggk0x2q 445 87 degranulation degranulation NN cord-007796-zggk0x2q 445 88 in in IN cord-007796-zggk0x2q 445 89 the the DT cord-007796-zggk0x2q 445 90 respiratory respiratory JJ cord-007796-zggk0x2q 445 91 tract tract NN cord-007796-zggk0x2q 445 92 during during IN cord-007796-zggk0x2q 445 93 naturally naturally RB cord-007796-zggk0x2q 445 94 acquired acquire VBN cord-007796-zggk0x2q 445 95 respiratory respiratory JJ cord-007796-zggk0x2q 445 96 syncytial syncytial JJ cord-007796-zggk0x2q 445 97 virus virus NN cord-007796-zggk0x2q 445 98 infection infection NN cord-007796-zggk0x2q 445 99 Respiratory respiratory JJ cord-007796-zggk0x2q 445 100 syncytial syncytial JJ cord-007796-zggk0x2q 445 101 virus virus NN cord-007796-zggk0x2q 445 102 infection infection NN cord-007796-zggk0x2q 445 103 of of IN cord-007796-zggk0x2q 445 104 human human JJ cord-007796-zggk0x2q 445 105 respiratory respiratory JJ cord-007796-zggk0x2q 445 106 epithelial epithelial JJ cord-007796-zggk0x2q 445 107 cells cell NNS cord-007796-zggk0x2q 445 108 up up RB cord-007796-zggk0x2q 445 109 - - HYPH cord-007796-zggk0x2q 445 110 regulates regulate VBZ cord-007796-zggk0x2q 445 111 class class NN cord-007796-zggk0x2q 445 112 I -PRON- PRP cord-007796-zggk0x2q 445 113 MHC MHC NNP cord-007796-zggk0x2q 445 114 expression expression NN cord-007796-zggk0x2q 445 115 through through IN cord-007796-zggk0x2q 445 116 the the DT cord-007796-zggk0x2q 445 117 induction induction NN cord-007796-zggk0x2q 445 118 of of IN cord-007796-zggk0x2q 445 119 IFN IFN NNP cord-007796-zggk0x2q 445 120 - - HYPH cord-007796-zggk0x2q 445 121 beta beta NNP cord-007796-zggk0x2q 445 122 and and CC cord-007796-zggk0x2q 445 123 IL-1 IL-1 NNP cord-007796-zggk0x2q 445 124 alpha alpha NN cord-007796-zggk0x2q 445 125 Epithelial epithelial JJ cord-007796-zggk0x2q 445 126 regulation regulation NN cord-007796-zggk0x2q 445 127 of of IN cord-007796-zggk0x2q 445 128 innate innate JJ cord-007796-zggk0x2q 445 129 immunity immunity NN cord-007796-zggk0x2q 445 130 to to IN cord-007796-zggk0x2q 445 131 respiratory respiratory JJ cord-007796-zggk0x2q 445 132 syncytial syncytial JJ cord-007796-zggk0x2q 445 133 virus virus NN cord-007796-zggk0x2q 445 134 Rhinovirus Rhinovirus NNP cord-007796-zggk0x2q 445 135 respiratory respiratory JJ cord-007796-zggk0x2q 445 136 infections infection NNS cord-007796-zggk0x2q 445 137 and and CC cord-007796-zggk0x2q 445 138 asthma asthma NN cord-007796-zggk0x2q 445 139 Relationship relationship NN cord-007796-zggk0x2q 445 140 of of IN cord-007796-zggk0x2q 445 141 viral viral JJ cord-007796-zggk0x2q 445 142 infections infection NNS cord-007796-zggk0x2q 445 143 to to IN cord-007796-zggk0x2q 445 144 wheezing wheeze VBG cord-007796-zggk0x2q 445 145 illnesses illness NNS cord-007796-zggk0x2q 445 146 and and CC cord-007796-zggk0x2q 445 147 asthma asthma NN cord-007796-zggk0x2q 445 148 Role role NN cord-007796-zggk0x2q 445 149 of of IN cord-007796-zggk0x2q 445 150 T T NNP cord-007796-zggk0x2q 445 151 lymphocyte lymphocyte NN cord-007796-zggk0x2q 445 152 subsets subset NNS cord-007796-zggk0x2q 445 153 in in IN cord-007796-zggk0x2q 445 154 the the DT cord-007796-zggk0x2q 445 155 pathogenesis pathogenesis NN cord-007796-zggk0x2q 445 156 of of IN cord-007796-zggk0x2q 445 157 primary primary JJ cord-007796-zggk0x2q 445 158 infection infection NN cord-007796-zggk0x2q 445 159 and and CC cord-007796-zggk0x2q 445 160 rechallenge rechallenge NN cord-007796-zggk0x2q 445 161 with with IN cord-007796-zggk0x2q 445 162 respiratory respiratory JJ cord-007796-zggk0x2q 445 163 syncytial syncytial JJ cord-007796-zggk0x2q 445 164 virus virus NN cord-007796-zggk0x2q 445 165 in in IN cord-007796-zggk0x2q 445 166 mice mouse NNS cord-007796-zggk0x2q 445 167 Immune immune NN cord-007796-zggk0x2q 445 168 - - HYPH cord-007796-zggk0x2q 445 169 mediated mediate VBN cord-007796-zggk0x2q 445 170 disease disease NN cord-007796-zggk0x2q 445 171 pathogenesis pathogenesis NN cord-007796-zggk0x2q 445 172 in in IN cord-007796-zggk0x2q 445 173 respiratory respiratory JJ cord-007796-zggk0x2q 445 174 syncytial syncytial JJ cord-007796-zggk0x2q 445 175 virus virus NN cord-007796-zggk0x2q 445 176 infection infection NN cord-007796-zggk0x2q 445 177 Human Human NNP cord-007796-zggk0x2q 445 178 metapneumovirus metapneumovirus NN cord-007796-zggk0x2q 445 179 in in IN cord-007796-zggk0x2q 445 180 severe severe JJ cord-007796-zggk0x2q 445 181 respiratory respiratory JJ cord-007796-zggk0x2q 445 182 syncytial syncytial JJ cord-007796-zggk0x2q 445 183 virus virus NN cord-007796-zggk0x2q 445 184 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 445 185 Winter winter NN cord-007796-zggk0x2q 445 186 viruses virus NNS cord-007796-zggk0x2q 445 187 : : : cord-007796-zggk0x2q 445 188 Influenza influenza NN cord-007796-zggk0x2q 445 189 - - HYPH cord-007796-zggk0x2q 445 190 and and CC cord-007796-zggk0x2q 445 191 respiratory respiratory JJ cord-007796-zggk0x2q 445 192 syncytial syncytial JJ cord-007796-zggk0x2q 445 193 virus virus NN cord-007796-zggk0x2q 445 194 - - HYPH cord-007796-zggk0x2q 445 195 related relate VBN cord-007796-zggk0x2q 445 196 morbidity morbidity NN cord-007796-zggk0x2q 445 197 in in IN cord-007796-zggk0x2q 445 198 chronic chronic JJ cord-007796-zggk0x2q 445 199 lung lung NN cord-007796-zggk0x2q 445 200 disease disease NN cord-007796-zggk0x2q 445 201 Rhinovirus Rhinovirus NNP cord-007796-zggk0x2q 445 202 and and CC cord-007796-zggk0x2q 445 203 acute acute JJ cord-007796-zggk0x2q 445 204 respiratory respiratory JJ cord-007796-zggk0x2q 445 205 infections infection NNS cord-007796-zggk0x2q 445 206 in in IN cord-007796-zggk0x2q 445 207 hospitalized hospitalize VBN cord-007796-zggk0x2q 445 208 children child NNS cord-007796-zggk0x2q 445 209 . . . cord-007796-zggk0x2q 446 1 Retrospective retrospective JJ cord-007796-zggk0x2q 446 2 study study NN cord-007796-zggk0x2q 446 3 Respiratory respiratory JJ cord-007796-zggk0x2q 446 4 syncytial syncytial JJ cord-007796-zggk0x2q 446 5 virus virus NN cord-007796-zggk0x2q 446 6 -- -- : cord-007796-zggk0x2q 446 7 Viral viral JJ cord-007796-zggk0x2q 446 8 biology biology NN cord-007796-zggk0x2q 446 9 and and CC cord-007796-zggk0x2q 446 10 the the DT cord-007796-zggk0x2q 446 11 host host NN cord-007796-zggk0x2q 446 12 response response NN cord-007796-zggk0x2q 447 1 Perflubron Perflubron NNP cord-007796-zggk0x2q 447 2 reduces reduce VBZ cord-007796-zggk0x2q 447 3 lung lung NN cord-007796-zggk0x2q 447 4 inflammation inflammation NN cord-007796-zggk0x2q 447 5 in in IN cord-007796-zggk0x2q 447 6 respiratory respiratory JJ cord-007796-zggk0x2q 447 7 syncytial syncytial JJ cord-007796-zggk0x2q 447 8 virus virus NN cord-007796-zggk0x2q 447 9 infection infection NN cord-007796-zggk0x2q 447 10 by by IN cord-007796-zggk0x2q 447 11 inhibiting inhibit VBG cord-007796-zggk0x2q 447 12 chemokine chemokine NN cord-007796-zggk0x2q 447 13 expression expression NN cord-007796-zggk0x2q 447 14 and and CC cord-007796-zggk0x2q 447 15 nuclear nuclear JJ cord-007796-zggk0x2q 447 16 factor factor NN cord-007796-zggk0x2q 447 17 - - HYPH cord-007796-zggk0x2q 447 18 kappa kappa NN cord-007796-zggk0x2q 447 19 B B NNP cord-007796-zggk0x2q 447 20 activation activation NN cord-007796-zggk0x2q 447 21 Respiratory respiratory JJ cord-007796-zggk0x2q 447 22 syncytial syncytial JJ cord-007796-zggk0x2q 447 23 virus virus NN cord-007796-zggk0x2q 447 24 - - HYPH cord-007796-zggk0x2q 447 25 induced induce VBN cord-007796-zggk0x2q 447 26 activation activation NN cord-007796-zggk0x2q 447 27 of of IN cord-007796-zggk0x2q 447 28 nuclear nuclear JJ cord-007796-zggk0x2q 447 29 factor factor NN cord-007796-zggk0x2q 447 30 - - : cord-007796-zggk0x2q 447 31 kappaB kappaB NNP cord-007796-zggk0x2q 447 32 in in IN cord-007796-zggk0x2q 447 33 the the DT cord-007796-zggk0x2q 447 34 lung lung NN cord-007796-zggk0x2q 447 35 involves involve VBZ cord-007796-zggk0x2q 447 36 alveolar alveolar NN cord-007796-zggk0x2q 447 37 macrophages macrophage NNS cord-007796-zggk0x2q 447 38 and and CC cord-007796-zggk0x2q 447 39 toll toll NN cord-007796-zggk0x2q 447 40 - - HYPH cord-007796-zggk0x2q 447 41 like like JJ cord-007796-zggk0x2q 447 42 receptor receptor NN cord-007796-zggk0x2q 447 43 4-dependent 4-dependent CD cord-007796-zggk0x2q 447 44 pathways pathway NNS cord-007796-zggk0x2q 447 45 Respiratory respiratory JJ cord-007796-zggk0x2q 447 46 syncytial syncytial JJ cord-007796-zggk0x2q 447 47 virus virus NN cord-007796-zggk0x2q 447 48 and and CC cord-007796-zggk0x2q 447 49 parainfluenza parainfluenza NNP cord-007796-zggk0x2q 447 50 virus virus NNP cord-007796-zggk0x2q 448 1 Enhanced enhanced JJ cord-007796-zggk0x2q 448 2 adherence adherence NN cord-007796-zggk0x2q 448 3 of of IN cord-007796-zggk0x2q 448 4 Streptococcus streptococcus NN cord-007796-zggk0x2q 448 5 pneumoniae pneumoniae NN cord-007796-zggk0x2q 448 6 to to IN cord-007796-zggk0x2q 448 7 human human JJ cord-007796-zggk0x2q 448 8 epithelial epithelial JJ cord-007796-zggk0x2q 448 9 cells cell NNS cord-007796-zggk0x2q 448 10 infected infect VBN cord-007796-zggk0x2q 448 11 with with IN cord-007796-zggk0x2q 448 12 respiratory respiratory JJ cord-007796-zggk0x2q 448 13 syncytial syncytial JJ cord-007796-zggk0x2q 448 14 virus virus NN cord-007796-zggk0x2q 448 15 Tissue tissue NN cord-007796-zggk0x2q 448 16 distribution distribution NN cord-007796-zggk0x2q 448 17 of of IN cord-007796-zggk0x2q 448 18 ACE2 ACE2 NNP cord-007796-zggk0x2q 448 19 protein protein NN cord-007796-zggk0x2q 448 20 , , , cord-007796-zggk0x2q 448 21 the the DT cord-007796-zggk0x2q 448 22 functional functional JJ cord-007796-zggk0x2q 448 23 receptor receptor NN cord-007796-zggk0x2q 448 24 for for IN cord-007796-zggk0x2q 448 25 SARS SARS NNP cord-007796-zggk0x2q 448 26 coronavirus coronavirus NN cord-007796-zggk0x2q 448 27 . . . cord-007796-zggk0x2q 449 1 A a DT cord-007796-zggk0x2q 449 2 first first JJ cord-007796-zggk0x2q 449 3 step step NN cord-007796-zggk0x2q 449 4 in in IN cord-007796-zggk0x2q 449 5 understanding understand VBG cord-007796-zggk0x2q 449 6 SARS SARS NNP cord-007796-zggk0x2q 449 7 pathogenesis pathogenesis NN cord-007796-zggk0x2q 449 8 Binding Binding NNP cord-007796-zggk0x2q 449 9 and and CC cord-007796-zggk0x2q 449 10 entry entry NN cord-007796-zggk0x2q 449 11 of of IN cord-007796-zggk0x2q 449 12 respiratory respiratory JJ cord-007796-zggk0x2q 449 13 syncytial syncytial JJ cord-007796-zggk0x2q 449 14 virus virus NN cord-007796-zggk0x2q 449 15 into into IN cord-007796-zggk0x2q 449 16 host host NN cord-007796-zggk0x2q 449 17 cells cell NNS cord-007796-zggk0x2q 449 18 and and CC cord-007796-zggk0x2q 449 19 initiation initiation NN cord-007796-zggk0x2q 449 20 of of IN cord-007796-zggk0x2q 449 21 the the DT cord-007796-zggk0x2q 449 22 innate innate JJ cord-007796-zggk0x2q 449 23 immune immune JJ cord-007796-zggk0x2q 449 24 response response NN cord-007796-zggk0x2q 449 25 Respiratory respiratory JJ cord-007796-zggk0x2q 449 26 syncytical syncytical JJ cord-007796-zggk0x2q 449 27 virus virus NN cord-007796-zggk0x2q 449 28 - - HYPH cord-007796-zggk0x2q 449 29 induced induce VBN cord-007796-zggk0x2q 449 30 chemokine chemokine NN cord-007796-zggk0x2q 449 31 expression expression NN cord-007796-zggk0x2q 449 32 in in IN cord-007796-zggk0x2q 449 33 the the DT cord-007796-zggk0x2q 449 34 lower low JJR cord-007796-zggk0x2q 449 35 airways airway NNS cord-007796-zggk0x2q 449 36 : : : cord-007796-zggk0x2q 450 1 Eosinophil eosinophil JJ cord-007796-zggk0x2q 450 2 recruitment recruitment NN cord-007796-zggk0x2q 450 3 and and CC cord-007796-zggk0x2q 450 4 degranulation degranulation NN cord-007796-zggk0x2q 450 5 Involvement Involvement NNP cord-007796-zggk0x2q 450 6 of of IN cord-007796-zggk0x2q 450 7 toll toll NN cord-007796-zggk0x2q 450 8 - - HYPH cord-007796-zggk0x2q 450 9 like like JJ cord-007796-zggk0x2q 450 10 receptor receptor NN cord-007796-zggk0x2q 450 11 4 4 CD cord-007796-zggk0x2q 450 12 in in IN cord-007796-zggk0x2q 450 13 innate innate JJ cord-007796-zggk0x2q 450 14 immunity immunity NN cord-007796-zggk0x2q 450 15 to to IN cord-007796-zggk0x2q 450 16 respiratory respiratory JJ cord-007796-zggk0x2q 450 17 syncytial syncytial JJ cord-007796-zggk0x2q 450 18 virus virus NN cord-007796-zggk0x2q 450 19 Effects effect NNS cord-007796-zggk0x2q 450 20 of of IN cord-007796-zggk0x2q 450 21 viral viral JJ cord-007796-zggk0x2q 450 22 lower low JJR cord-007796-zggk0x2q 450 23 respiratory respiratory JJ cord-007796-zggk0x2q 450 24 tract tract NN cord-007796-zggk0x2q 450 25 infection infection NN cord-007796-zggk0x2q 450 26 on on IN cord-007796-zggk0x2q 450 27 lung lung NN cord-007796-zggk0x2q 450 28 function function NN cord-007796-zggk0x2q 450 29 in in IN cord-007796-zggk0x2q 450 30 infants infant NNS cord-007796-zggk0x2q 450 31 with with IN cord-007796-zggk0x2q 450 32 cystic cystic JJ cord-007796-zggk0x2q 450 33 fibrosis fibrosis NN cord-007796-zggk0x2q 450 34 Influence influence NN cord-007796-zggk0x2q 450 35 of of IN cord-007796-zggk0x2q 450 36 promoter promoter NN cord-007796-zggk0x2q 450 37 variants variant NNS cord-007796-zggk0x2q 450 38 of of IN cord-007796-zggk0x2q 450 39 interleukin-10 interleukin-10 NN cord-007796-zggk0x2q 450 40 , , , cord-007796-zggk0x2q 450 41 interleukin-9 interleukin-9 NNP cord-007796-zggk0x2q 450 42 , , , cord-007796-zggk0x2q 450 43 and and CC cord-007796-zggk0x2q 450 44 tumor tumor NN cord-007796-zggk0x2q 450 45 necrosis necrosis NN cord-007796-zggk0x2q 450 46 factor factor NN cord-007796-zggk0x2q 450 47 - - HYPH cord-007796-zggk0x2q 450 48 alpha alpha NN cord-007796-zggk0x2q 450 49 genes gene NNS cord-007796-zggk0x2q 450 50 on on IN cord-007796-zggk0x2q 450 51 respiratory respiratory JJ cord-007796-zggk0x2q 450 52 syncytial syncytial JJ cord-007796-zggk0x2q 450 53 virus virus NN cord-007796-zggk0x2q 450 54 bronchiolitis bronchioliti VBN cord-007796-zggk0x2q 450 55 Association Association NNP cord-007796-zggk0x2q 450 56 of of IN cord-007796-zggk0x2q 450 57 severe severe JJ cord-007796-zggk0x2q 450 58 respiratory respiratory JJ cord-007796-zggk0x2q 450 59 syncytial syncytial JJ cord-007796-zggk0x2q 450 60 virus virus NN cord-007796-zggk0x2q 450 61 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 450 62 with with IN cord-007796-zggk0x2q 450 63 interleukin-4 interleukin-4 NNP cord-007796-zggk0x2q 450 64 and and CC cord-007796-zggk0x2q 450 65 interleukin-4 interleukin-4 NNP cord-007796-zggk0x2q 450 66 receptor receptor NN cord-007796-zggk0x2q 450 67 alpha alpha NN cord-007796-zggk0x2q 450 68 polymorphisms polymorphism NNS cord-007796-zggk0x2q 450 69 Interactions interaction NNS cord-007796-zggk0x2q 450 70 between between IN cord-007796-zggk0x2q 450 71 RSV RSV NNP cord-007796-zggk0x2q 450 72 infection infection NN cord-007796-zggk0x2q 450 73 , , , cord-007796-zggk0x2q 450 74 asthma asthma NN cord-007796-zggk0x2q 450 75 , , , cord-007796-zggk0x2q 450 76 and and CC cord-007796-zggk0x2q 450 77 atopy atopy NN cord-007796-zggk0x2q 450 78 : : : cord-007796-zggk0x2q 451 1 Unraveling unravel VBG cord-007796-zggk0x2q 451 2 the the DT cord-007796-zggk0x2q 451 3 complexities complexity NNS cord-007796-zggk0x2q 451 4 Silencing silence VBG cord-007796-zggk0x2q 451 5 STATs stat NNS cord-007796-zggk0x2q 451 6 : : : cord-007796-zggk0x2q 451 7 Lessons lesson NNS cord-007796-zggk0x2q 451 8 from from IN cord-007796-zggk0x2q 451 9 paramyxovirus paramyxovirus JJ cord-007796-zggk0x2q 451 10 interferon interferon NN cord-007796-zggk0x2q 451 11 evasion evasion NN cord-007796-zggk0x2q 452 1 Adenovirus Adenovirus NNP cord-007796-zggk0x2q 452 2 interaction interaction NN cord-007796-zggk0x2q 452 3 with with IN cord-007796-zggk0x2q 452 4 its -PRON- PRP$ cord-007796-zggk0x2q 452 5 cellular cellular JJ cord-007796-zggk0x2q 452 6 receptor receptor NN cord-007796-zggk0x2q 452 7 CAR car NN cord-007796-zggk0x2q 452 8 Unusual unusual JJ cord-007796-zggk0x2q 452 9 haplotypic haplotypic JJ cord-007796-zggk0x2q 452 10 structure structure NN cord-007796-zggk0x2q 452 11 of of IN cord-007796-zggk0x2q 452 12 IL8 IL8 NNP cord-007796-zggk0x2q 452 13 , , , cord-007796-zggk0x2q 452 14 a a DT cord-007796-zggk0x2q 452 15 susceptibility susceptibility NN cord-007796-zggk0x2q 452 16 locus locus NN cord-007796-zggk0x2q 452 17 for for IN cord-007796-zggk0x2q 452 18 a a DT cord-007796-zggk0x2q 452 19 common common JJ cord-007796-zggk0x2q 452 20 respiratory respiratory JJ cord-007796-zggk0x2q 452 21 virus virus NN cord-007796-zggk0x2q 452 22 Variants variant NNS cord-007796-zggk0x2q 452 23 of of IN cord-007796-zggk0x2q 452 24 the the DT cord-007796-zggk0x2q 452 25 chemokine chemokine NN cord-007796-zggk0x2q 452 26 receptor receptor NN cord-007796-zggk0x2q 452 27 CCR5 CCR5 NNP cord-007796-zggk0x2q 452 28 are be VBP cord-007796-zggk0x2q 452 29 associated associate VBN cord-007796-zggk0x2q 452 30 with with IN cord-007796-zggk0x2q 452 31 severe severe JJ cord-007796-zggk0x2q 452 32 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 452 33 caused cause VBN cord-007796-zggk0x2q 452 34 by by IN cord-007796-zggk0x2q 452 35 respiratory respiratory JJ cord-007796-zggk0x2q 452 36 syncytial syncytial JJ cord-007796-zggk0x2q 452 37 virus virus NN cord-007796-zggk0x2q 452 38 Intracellular Intracellular NNP cord-007796-zggk0x2q 452 39 IFN IFN NNP cord-007796-zggk0x2q 452 40 - - HYPH cord-007796-zggk0x2q 452 41 gamma gamma JJ cord-007796-zggk0x2q 452 42 expression expression NN cord-007796-zggk0x2q 452 43 in in IN cord-007796-zggk0x2q 452 44 natural natural JJ cord-007796-zggk0x2q 452 45 killer killer NN cord-007796-zggk0x2q 452 46 cells cell NNS cord-007796-zggk0x2q 452 47 precedes precede VBZ cord-007796-zggk0x2q 452 48 lung lung NN cord-007796-zggk0x2q 452 49 CD8ϩ CD8ϩ NNP cord-007796-zggk0x2q 452 50 T T NNP cord-007796-zggk0x2q 452 51 cell cell NN cord-007796-zggk0x2q 452 52 recruitment recruitment NN cord-007796-zggk0x2q 452 53 during during IN cord-007796-zggk0x2q 452 54 respiratory respiratory JJ cord-007796-zggk0x2q 452 55 syncytial syncytial JJ cord-007796-zggk0x2q 452 56 virus virus NN cord-007796-zggk0x2q 452 57 infection infection NN cord-007796-zggk0x2q 452 58 Metapneumovirus Metapneumovirus NNP cord-007796-zggk0x2q 452 59 and and CC cord-007796-zggk0x2q 452 60 acute acute JJ cord-007796-zggk0x2q 452 61 wheezing wheeze VBG cord-007796-zggk0x2q 452 62 in in IN cord-007796-zggk0x2q 452 63 children child NNS cord-007796-zggk0x2q 452 64 Community Community NNP cord-007796-zggk0x2q 452 65 study study NN cord-007796-zggk0x2q 452 66 of of IN cord-007796-zggk0x2q 452 67 role role NN cord-007796-zggk0x2q 452 68 of of IN cord-007796-zggk0x2q 452 69 viral viral JJ cord-007796-zggk0x2q 452 70 infections infection NNS cord-007796-zggk0x2q 452 71 in in IN cord-007796-zggk0x2q 452 72 exacerbations exacerbation NNS cord-007796-zggk0x2q 452 73 of of IN cord-007796-zggk0x2q 452 74 asthma asthma NN cord-007796-zggk0x2q 452 75 in in IN cord-007796-zggk0x2q 452 76 9 9 CD cord-007796-zggk0x2q 452 77 - - SYM cord-007796-zggk0x2q 452 78 11 11 CD cord-007796-zggk0x2q 452 79 year year NN cord-007796-zggk0x2q 452 80 old old JJ cord-007796-zggk0x2q 452 81 children child NNS cord-007796-zggk0x2q 452 82 Respiratory respiratory JJ cord-007796-zggk0x2q 452 83 syncytial syncytial JJ cord-007796-zggk0x2q 452 84 virus virus NN cord-007796-zggk0x2q 452 85 infection infection NN cord-007796-zggk0x2q 452 86 in in IN cord-007796-zggk0x2q 452 87 the the DT cord-007796-zggk0x2q 452 88 late late JJ cord-007796-zggk0x2q 452 89 bone bone NN cord-007796-zggk0x2q 452 90 marrow marrow NN cord-007796-zggk0x2q 452 91 transplant transplant NN cord-007796-zggk0x2q 452 92 period period NN cord-007796-zggk0x2q 452 93 : : : cord-007796-zggk0x2q 452 94 Report report NN cord-007796-zggk0x2q 452 95 of of IN cord-007796-zggk0x2q 452 96 three three CD cord-007796-zggk0x2q 452 97 cases case NNS cord-007796-zggk0x2q 452 98 and and CC cord-007796-zggk0x2q 452 99 review review VB cord-007796-zggk0x2q 452 100 Role role NN cord-007796-zggk0x2q 452 101 of of IN cord-007796-zggk0x2q 452 102 NF nf NN cord-007796-zggk0x2q 452 103 - - HYPH cord-007796-zggk0x2q 452 104 kappa kappa NN cord-007796-zggk0x2q 452 105 B b NN cord-007796-zggk0x2q 452 106 in in IN cord-007796-zggk0x2q 452 107 cytokine cytokine NN cord-007796-zggk0x2q 452 108 production production NN cord-007796-zggk0x2q 452 109 induced induce VBN cord-007796-zggk0x2q 452 110 from from IN cord-007796-zggk0x2q 452 111 human human JJ cord-007796-zggk0x2q 452 112 airway airway NN cord-007796-zggk0x2q 452 113 epithelial epithelial JJ cord-007796-zggk0x2q 452 114 cells cell NNS cord-007796-zggk0x2q 452 115 by by IN cord-007796-zggk0x2q 452 116 rhinovirus rhinovirus NN cord-007796-zggk0x2q 452 117 infection infection NN cord-007796-zggk0x2q 452 118 Activation Activation NNP cord-007796-zggk0x2q 452 119 of of IN cord-007796-zggk0x2q 452 120 human human JJ cord-007796-zggk0x2q 452 121 eosinophils eosinophil NNS cord-007796-zggk0x2q 452 122 in in IN cord-007796-zggk0x2q 452 123 vitro vitro FW cord-007796-zggk0x2q 452 124 by by IN cord-007796-zggk0x2q 452 125 respiratory respiratory JJ cord-007796-zggk0x2q 452 126 syncytial syncytial JJ cord-007796-zggk0x2q 452 127 virus virus NN cord-007796-zggk0x2q 452 128 Community community NN cord-007796-zggk0x2q 452 129 respiratory respiratory JJ cord-007796-zggk0x2q 452 130 viruses virus NNS cord-007796-zggk0x2q 452 131 in in IN cord-007796-zggk0x2q 452 132 individuals individual NNS cord-007796-zggk0x2q 452 133 with with IN cord-007796-zggk0x2q 452 134 human human JJ cord-007796-zggk0x2q 452 135 immunodeficiency immunodeficiency NN cord-007796-zggk0x2q 452 136 virus virus NN cord-007796-zggk0x2q 452 137 infection infection NN cord-007796-zggk0x2q 452 138 Risk risk NN cord-007796-zggk0x2q 452 139 factors factor NNS cord-007796-zggk0x2q 452 140 for for IN cord-007796-zggk0x2q 452 141 respiratory respiratory JJ cord-007796-zggk0x2q 452 142 syncytial syncytial JJ cord-007796-zggk0x2q 452 143 virus virus NN cord-007796-zggk0x2q 452 144 associated associate VBD cord-007796-zggk0x2q 452 145 apnoea apnoea NN cord-007796-zggk0x2q 452 146 Relationship relationship NN cord-007796-zggk0x2q 452 147 between between IN cord-007796-zggk0x2q 452 148 clinical clinical JJ cord-007796-zggk0x2q 452 149 severity severity NN cord-007796-zggk0x2q 452 150 of of IN cord-007796-zggk0x2q 452 151 respiratory respiratory JJ cord-007796-zggk0x2q 452 152 syncytial syncytial JJ cord-007796-zggk0x2q 452 153 virus virus NN cord-007796-zggk0x2q 452 154 infection infection NN cord-007796-zggk0x2q 452 155 and and CC cord-007796-zggk0x2q 453 1 subtype subtype NN cord-007796-zggk0x2q 453 2 Respiratory respiratory JJ cord-007796-zggk0x2q 453 3 syncytial syncytial JJ cord-007796-zggk0x2q 453 4 virus virus NN cord-007796-zggk0x2q 453 5 infection infection NN cord-007796-zggk0x2q 453 6 sensitizes sensitize VBZ cord-007796-zggk0x2q 453 7 cells cell NNS cord-007796-zggk0x2q 453 8 to to IN cord-007796-zggk0x2q 453 9 apoptosis apoptosis NN cord-007796-zggk0x2q 453 10 mediated mediate VBN cord-007796-zggk0x2q 453 11 by by IN cord-007796-zggk0x2q 453 12 tumor tumor NN cord-007796-zggk0x2q 453 13 necrosis necrosis NN cord-007796-zggk0x2q 453 14 factor factor NN cord-007796-zggk0x2q 453 15 - - HYPH cord-007796-zggk0x2q 453 16 related relate VBN cord-007796-zggk0x2q 453 17 apoptosisinducing apoptosisinducing NN cord-007796-zggk0x2q 453 18 ligand ligand NN cord-007796-zggk0x2q 453 19 Alterations alteration NNS cord-007796-zggk0x2q 453 20 in in IN cord-007796-zggk0x2q 453 21 apoptosis apoptosis NN cord-007796-zggk0x2q 453 22 of of IN cord-007796-zggk0x2q 453 23 cord cord NN cord-007796-zggk0x2q 453 24 and and CC cord-007796-zggk0x2q 453 25 adult adult NN cord-007796-zggk0x2q 453 26 peripheral peripheral JJ cord-007796-zggk0x2q 453 27 blood blood NN cord-007796-zggk0x2q 453 28 mononuclear mononuclear NN cord-007796-zggk0x2q 453 29 cells cell NNS cord-007796-zggk0x2q 453 30 induced induce VBN cord-007796-zggk0x2q 453 31 by by IN cord-007796-zggk0x2q 453 32 in in IN cord-007796-zggk0x2q 453 33 vitro vitro FW cord-007796-zggk0x2q 453 34 infection infection NN cord-007796-zggk0x2q 453 35 with with IN cord-007796-zggk0x2q 453 36 respiratory respiratory JJ cord-007796-zggk0x2q 453 37 syncytial syncytial JJ cord-007796-zggk0x2q 453 38 virus virus NN cord-007796-zggk0x2q 453 39 Differential differential JJ cord-007796-zggk0x2q 453 40 production production NN cord-007796-zggk0x2q 453 41 of of IN cord-007796-zggk0x2q 453 42 inflammatory inflammatory JJ cord-007796-zggk0x2q 453 43 cytokines cytokine NNS cord-007796-zggk0x2q 453 44 in in IN cord-007796-zggk0x2q 453 45 primary primary JJ cord-007796-zggk0x2q 453 46 infection infection NN cord-007796-zggk0x2q 453 47 with with IN cord-007796-zggk0x2q 453 48 human human JJ cord-007796-zggk0x2q 453 49 metapneumovirus metapneumovirus NN cord-007796-zggk0x2q 453 50 and and CC cord-007796-zggk0x2q 453 51 with with IN cord-007796-zggk0x2q 453 52 other other JJ cord-007796-zggk0x2q 453 53 common common JJ cord-007796-zggk0x2q 453 54 respiratory respiratory JJ cord-007796-zggk0x2q 453 55 viruses virus NNS cord-007796-zggk0x2q 453 56 of of IN cord-007796-zggk0x2q 453 57 infancy infancy NN cord-007796-zggk0x2q 453 58 Surfactant Surfactant NNP cord-007796-zggk0x2q 453 59 protein protein NN cord-007796-zggk0x2q 453 60 D d NN cord-007796-zggk0x2q 453 61 gene gene NN cord-007796-zggk0x2q 453 62 polymorphism polymorphism NN cord-007796-zggk0x2q 453 63 associated associate VBN cord-007796-zggk0x2q 453 64 with with IN cord-007796-zggk0x2q 453 65 severe severe JJ cord-007796-zggk0x2q 453 66 respiratory respiratory JJ cord-007796-zggk0x2q 453 67 syncytial syncytial JJ cord-007796-zggk0x2q 453 68 virus virus NN cord-007796-zggk0x2q 453 69 infection infection NN cord-007796-zggk0x2q 453 70 Adenovirus Adenovirus NNP cord-007796-zggk0x2q 453 71 surveillance surveillance NN cord-007796-zggk0x2q 453 72 on on IN cord-007796-zggk0x2q 453 73 children child NNS cord-007796-zggk0x2q 453 74 hospitalized hospitalize VBN cord-007796-zggk0x2q 453 75 for for IN cord-007796-zggk0x2q 453 76 acute acute JJ cord-007796-zggk0x2q 453 77 lower low JJR cord-007796-zggk0x2q 453 78 respiratory respiratory JJ cord-007796-zggk0x2q 453 79 infections infection NNS cord-007796-zggk0x2q 453 80 in in IN cord-007796-zggk0x2q 453 81 Chile Chile NNP cord-007796-zggk0x2q 453 82 ( ( -LRB- cord-007796-zggk0x2q 453 83 1988 1988 CD cord-007796-zggk0x2q 453 84 - - SYM cord-007796-zggk0x2q 453 85 1996 1996 CD cord-007796-zggk0x2q 453 86 ) ) -RRB- cord-007796-zggk0x2q 454 1 Type type NN cord-007796-zggk0x2q 454 2 1 1 CD cord-007796-zggk0x2q 454 3 and and CC cord-007796-zggk0x2q 454 4 type type NN cord-007796-zggk0x2q 454 5 2 2 CD cord-007796-zggk0x2q 454 6 cytokine cytokine NN cord-007796-zggk0x2q 454 7 imbalance imbalance NN cord-007796-zggk0x2q 454 8 in in IN cord-007796-zggk0x2q 454 9 acute acute JJ cord-007796-zggk0x2q 454 10 respiratory respiratory JJ cord-007796-zggk0x2q 454 11 syncytial syncytial JJ cord-007796-zggk0x2q 454 12 virus virus NN cord-007796-zggk0x2q 454 13 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 454 14 Viruses virus NNS cord-007796-zggk0x2q 454 15 and and CC cord-007796-zggk0x2q 454 16 asthma asthma NN cord-007796-zggk0x2q 454 17 : : : cord-007796-zggk0x2q 454 18 Inception inception NN cord-007796-zggk0x2q 454 19 , , , cord-007796-zggk0x2q 454 20 exacerbation exacerbation NN cord-007796-zggk0x2q 454 21 , , , cord-007796-zggk0x2q 454 22 and and CC cord-007796-zggk0x2q 454 23 possible possible JJ cord-007796-zggk0x2q 454 24 prevention prevention NN cord-007796-zggk0x2q 455 1 Severe severe JJ cord-007796-zggk0x2q 455 2 acute acute JJ cord-007796-zggk0x2q 455 3 respiratory respiratory JJ cord-007796-zggk0x2q 455 4 syndrome syndrome NN cord-007796-zggk0x2q 455 5 among among IN cord-007796-zggk0x2q 455 6 children child NNS cord-007796-zggk0x2q 455 7 Severe severe VBP cord-007796-zggk0x2q 455 8 acute acute JJ cord-007796-zggk0x2q 455 9 respiratory respiratory JJ cord-007796-zggk0x2q 455 10 syndrome syndrome NN cord-007796-zggk0x2q 455 11 ( ( -LRB- cord-007796-zggk0x2q 455 12 SARS SARS NNP cord-007796-zggk0x2q 455 13 ) ) -RRB- cord-007796-zggk0x2q 455 14 in in IN cord-007796-zggk0x2q 455 15 children child NNS cord-007796-zggk0x2q 455 16 : : : cord-007796-zggk0x2q 455 17 Epidemiology epidemiology NN cord-007796-zggk0x2q 455 18 , , , cord-007796-zggk0x2q 455 19 presentation presentation NN cord-007796-zggk0x2q 455 20 and and CC cord-007796-zggk0x2q 455 21 management management NN cord-007796-zggk0x2q 455 22 Angiotensin Angiotensin NNP cord-007796-zggk0x2q 455 23 - - HYPH cord-007796-zggk0x2q 455 24 converting convert VBG cord-007796-zggk0x2q 455 25 enzyme enzyme NN cord-007796-zggk0x2q 455 26 2 2 CD cord-007796-zggk0x2q 455 27 is be VBZ cord-007796-zggk0x2q 455 28 a a DT cord-007796-zggk0x2q 455 29 functional functional JJ cord-007796-zggk0x2q 455 30 receptor receptor NN cord-007796-zggk0x2q 455 31 for for IN cord-007796-zggk0x2q 455 32 the the DT cord-007796-zggk0x2q 455 33 SARS SARS NNP cord-007796-zggk0x2q 455 34 coronavirus coronavirus NN cord-007796-zggk0x2q 455 35 Recognition Recognition NNP cord-007796-zggk0x2q 455 36 of of IN cord-007796-zggk0x2q 455 37 single single RB cord-007796-zggk0x2q 455 38 - - HYPH cord-007796-zggk0x2q 455 39 stranded strand VBN cord-007796-zggk0x2q 455 40 RNA RNA NNP cord-007796-zggk0x2q 455 41 viruses virus NNS cord-007796-zggk0x2q 455 42 by by IN cord-007796-zggk0x2q 455 43 Toll toll NN cord-007796-zggk0x2q 455 44 - - HYPH cord-007796-zggk0x2q 455 45 like like JJ cord-007796-zggk0x2q 455 46 receptor receptor NN cord-007796-zggk0x2q 455 47 7 7 CD cord-007796-zggk0x2q 455 48 Increased increase VBN cord-007796-zggk0x2q 455 49 burden burden NN cord-007796-zggk0x2q 455 50 of of IN cord-007796-zggk0x2q 455 51 respiratory respiratory JJ cord-007796-zggk0x2q 455 52 viral viral JJ cord-007796-zggk0x2q 455 53 associated associate VBN cord-007796-zggk0x2q 455 54 severe severe JJ cord-007796-zggk0x2q 455 55 lower low JJR cord-007796-zggk0x2q 455 56 respiratory respiratory JJ cord-007796-zggk0x2q 455 57 tract tract NN cord-007796-zggk0x2q 455 58 infections infection NNS cord-007796-zggk0x2q 455 59 in in IN cord-007796-zggk0x2q 455 60 children child NNS cord-007796-zggk0x2q 455 61 infected infect VBN cord-007796-zggk0x2q 455 62 with with IN cord-007796-zggk0x2q 455 63 human human JJ cord-007796-zggk0x2q 455 64 immunodeficiency immunodeficiency NN cord-007796-zggk0x2q 455 65 virus virus NN cord-007796-zggk0x2q 455 66 type-1 type-1 NNP cord-007796-zggk0x2q 455 67 Cross Cross NNP cord-007796-zggk0x2q 455 68 sectional sectional JJ cord-007796-zggk0x2q 455 69 retrospective retrospective JJ cord-007796-zggk0x2q 455 70 study study NN cord-007796-zggk0x2q 455 71 of of IN cord-007796-zggk0x2q 455 72 prevalence prevalence NN cord-007796-zggk0x2q 455 73 of of IN cord-007796-zggk0x2q 455 74 atopy atopy NN cord-007796-zggk0x2q 455 75 among among IN cord-007796-zggk0x2q 455 76 Italian italian JJ cord-007796-zggk0x2q 455 77 military military JJ cord-007796-zggk0x2q 455 78 students student NNS cord-007796-zggk0x2q 455 79 with with IN cord-007796-zggk0x2q 455 80 antibodies antibody NNS cord-007796-zggk0x2q 455 81 against against IN cord-007796-zggk0x2q 455 82 hepatitis hepatitis NNP cord-007796-zggk0x2q 455 83 A A NNP cord-007796-zggk0x2q 455 84 virus virus NN cord-007796-zggk0x2q 455 85 Human Human NNP cord-007796-zggk0x2q 455 86 metapneumovirus metapneumovirus NNP cord-007796-zggk0x2q 455 87 - - : cord-007796-zggk0x2q 455 88 An an DT cord-007796-zggk0x2q 455 89 important important JJ cord-007796-zggk0x2q 455 90 new new JJ cord-007796-zggk0x2q 455 91 respiratory respiratory JJ cord-007796-zggk0x2q 455 92 virus virus NN cord-007796-zggk0x2q 456 1 Interleukin interleukin NN cord-007796-zggk0x2q 456 2 9 9 CD cord-007796-zggk0x2q 456 3 production production NN cord-007796-zggk0x2q 456 4 in in IN cord-007796-zggk0x2q 456 5 the the DT cord-007796-zggk0x2q 456 6 lungs lung NNS cord-007796-zggk0x2q 456 7 of of IN cord-007796-zggk0x2q 456 8 infants infant NNS cord-007796-zggk0x2q 456 9 with with IN cord-007796-zggk0x2q 456 10 severe severe JJ cord-007796-zggk0x2q 456 11 respiratory respiratory JJ cord-007796-zggk0x2q 456 12 syncytial syncytial JJ cord-007796-zggk0x2q 456 13 virus virus NN cord-007796-zggk0x2q 456 14 bronchiolitis bronchioliti VBN cord-007796-zggk0x2q 456 15 Bronchoalveolar Bronchoalveolar NNP cord-007796-zggk0x2q 456 16 lavage lavage NN cord-007796-zggk0x2q 456 17 cellularity cellularity NN cord-007796-zggk0x2q 456 18 in in IN cord-007796-zggk0x2q 456 19 infants infant NNS cord-007796-zggk0x2q 456 20 with with IN cord-007796-zggk0x2q 456 21 severe severe JJ cord-007796-zggk0x2q 456 22 respiratory respiratory JJ cord-007796-zggk0x2q 456 23 syncytial syncytial JJ cord-007796-zggk0x2q 456 24 virus virus NN cord-007796-zggk0x2q 456 25 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 456 26 Clinical clinical JJ cord-007796-zggk0x2q 456 27 characteristics characteristic NNS cord-007796-zggk0x2q 456 28 of of IN cord-007796-zggk0x2q 456 29 respiratory respiratory JJ cord-007796-zggk0x2q 456 30 syncytial syncytial JJ cord-007796-zggk0x2q 456 31 virus virus NN cord-007796-zggk0x2q 456 32 infections infection NNS cord-007796-zggk0x2q 456 33 in in IN cord-007796-zggk0x2q 456 34 healthy healthy JJ cord-007796-zggk0x2q 456 35 versus versus IN cord-007796-zggk0x2q 457 1 previously previously RB cord-007796-zggk0x2q 457 2 compromised compromise VBN cord-007796-zggk0x2q 457 3 host host NN cord-007796-zggk0x2q 458 1 The the DT cord-007796-zggk0x2q 458 2 immunology immunology NN cord-007796-zggk0x2q 458 3 of of IN cord-007796-zggk0x2q 458 4 virus virus NN cord-007796-zggk0x2q 458 5 infection infection NN cord-007796-zggk0x2q 458 6 in in IN cord-007796-zggk0x2q 458 7 asthma asthma NN cord-007796-zggk0x2q 458 8 Immunoglobulin immunoglobulin NN cord-007796-zggk0x2q 458 9 class class NN cord-007796-zggk0x2q 458 10 - - HYPH cord-007796-zggk0x2q 458 11 specific specific JJ cord-007796-zggk0x2q 458 12 antibody antibody NN cord-007796-zggk0x2q 458 13 response response NN cord-007796-zggk0x2q 458 14 in in IN cord-007796-zggk0x2q 458 15 respiratory respiratory JJ cord-007796-zggk0x2q 458 16 syncytial syncytial JJ cord-007796-zggk0x2q 458 17 virus virus NN cord-007796-zggk0x2q 458 18 infection infection NN cord-007796-zggk0x2q 458 19 measured measure VBN cord-007796-zggk0x2q 458 20 by by IN cord-007796-zggk0x2q 458 21 enzyme enzyme NN cord-007796-zggk0x2q 458 22 immunoassay immunoassay JJ cord-007796-zggk0x2q 458 23 Respiratory respiratory JJ cord-007796-zggk0x2q 458 24 syncytial syncytial JJ cord-007796-zggk0x2q 458 25 virus virus NN cord-007796-zggk0x2q 458 26 up up RB cord-007796-zggk0x2q 458 27 - - HYPH cord-007796-zggk0x2q 458 28 regulates regulate VBZ cord-007796-zggk0x2q 458 29 TLR4 TLR4 NNP cord-007796-zggk0x2q 458 30 and and CC cord-007796-zggk0x2q 458 31 sensitizes sensitize VBZ cord-007796-zggk0x2q 458 32 airway airway NN cord-007796-zggk0x2q 458 33 epithelial epithelial JJ cord-007796-zggk0x2q 458 34 cells cell NNS cord-007796-zggk0x2q 458 35 to to TO cord-007796-zggk0x2q 458 36 endotoxin endotoxin VB cord-007796-zggk0x2q 458 37 Respiratory respiratory JJ cord-007796-zggk0x2q 458 38 syncytial syncytial JJ cord-007796-zggk0x2q 458 39 virusinfected virusinfecte VBN cord-007796-zggk0x2q 458 40 pulmonary pulmonary JJ cord-007796-zggk0x2q 458 41 epithelial epithelial JJ cord-007796-zggk0x2q 458 42 cells cell NNS cord-007796-zggk0x2q 458 43 induce induce VBP cord-007796-zggk0x2q 458 44 eosinophil eosinophil JJ cord-007796-zggk0x2q 458 45 degranulation degranulation NN cord-007796-zggk0x2q 458 46 by by IN cord-007796-zggk0x2q 458 47 a a DT cord-007796-zggk0x2q 458 48 CD18-mediated cd18-mediated CD cord-007796-zggk0x2q 458 49 mechanism mechanism NN cord-007796-zggk0x2q 458 50 Immunity immunity NN cord-007796-zggk0x2q 458 51 and and CC cord-007796-zggk0x2q 458 52 immunopathology immunopathology NN cord-007796-zggk0x2q 458 53 to to IN cord-007796-zggk0x2q 458 54 respiratory respiratory JJ cord-007796-zggk0x2q 458 55 syncytial syncytial JJ cord-007796-zggk0x2q 458 56 virus virus NN cord-007796-zggk0x2q 458 57 . . . cord-007796-zggk0x2q 459 1 The the DT cord-007796-zggk0x2q 459 2 mouse mouse NN cord-007796-zggk0x2q 459 3 model model NN cord-007796-zggk0x2q 459 4 Expression expression NN cord-007796-zggk0x2q 459 5 of of IN cord-007796-zggk0x2q 459 6 influenza influenza NN cord-007796-zggk0x2q 459 7 virus virus NN cord-007796-zggk0x2q 459 8 hemagglutinin hemagglutinin NN cord-007796-zggk0x2q 459 9 activates activate VBZ cord-007796-zggk0x2q 459 10 transcription transcription NN cord-007796-zggk0x2q 459 11 factor factor NN cord-007796-zggk0x2q 460 1 NF nf NN cord-007796-zggk0x2q 460 2 - - HYPH cord-007796-zggk0x2q 460 3 kappa kappa NN cord-007796-zggk0x2q 460 4 B B NNP cord-007796-zggk0x2q 460 5 Do do VBP cord-007796-zggk0x2q 460 6 rhinoviruses rhinovirus NNS cord-007796-zggk0x2q 460 7 cause cause VB cord-007796-zggk0x2q 460 8 pneumonia pneumonia NN cord-007796-zggk0x2q 460 9 in in IN cord-007796-zggk0x2q 460 10 children child NNS cord-007796-zggk0x2q 460 11 ? ? . cord-007796-zggk0x2q 461 1 Economic economic JJ cord-007796-zggk0x2q 461 2 impact impact NN cord-007796-zggk0x2q 461 3 of of IN cord-007796-zggk0x2q 461 4 respiratory respiratory JJ cord-007796-zggk0x2q 461 5 syncytial syncytial JJ cord-007796-zggk0x2q 461 6 virus virus NN cord-007796-zggk0x2q 461 7 - - HYPH cord-007796-zggk0x2q 461 8 related relate VBN cord-007796-zggk0x2q 461 9 illness illness NN cord-007796-zggk0x2q 461 10 in in IN cord-007796-zggk0x2q 461 11 the the DT cord-007796-zggk0x2q 461 12 US US NNP cord-007796-zggk0x2q 461 13 : : : cord-007796-zggk0x2q 462 1 An an DT cord-007796-zggk0x2q 462 2 analysis analysis NN cord-007796-zggk0x2q 462 3 of of IN cord-007796-zggk0x2q 462 4 national national JJ cord-007796-zggk0x2q 462 5 databases database NNS cord-007796-zggk0x2q 462 6 Viral viral JJ cord-007796-zggk0x2q 462 7 infections infection NNS cord-007796-zggk0x2q 462 8 , , , cord-007796-zggk0x2q 462 9 atopy atopy NN cord-007796-zggk0x2q 462 10 , , , cord-007796-zggk0x2q 462 11 and and CC cord-007796-zggk0x2q 462 12 asthma asthma NN cord-007796-zggk0x2q 463 1 : : : cord-007796-zggk0x2q 463 2 Is be VBZ cord-007796-zggk0x2q 463 3 there there EX cord-007796-zggk0x2q 463 4 a a DT cord-007796-zggk0x2q 463 5 causal causal JJ cord-007796-zggk0x2q 463 6 relationship relationship NN cord-007796-zggk0x2q 463 7 ? ? . cord-007796-zggk0x2q 464 1 Immune immune JJ cord-007796-zggk0x2q 464 2 interaction interaction NN cord-007796-zggk0x2q 464 3 between between IN cord-007796-zggk0x2q 464 4 respiratory respiratory JJ cord-007796-zggk0x2q 464 5 syncytial syncytial JJ cord-007796-zggk0x2q 464 6 virus virus NN cord-007796-zggk0x2q 464 7 infection infection NN cord-007796-zggk0x2q 464 8 and and CC cord-007796-zggk0x2q 464 9 allergen allergen NN cord-007796-zggk0x2q 464 10 sensitization sensitization NN cord-007796-zggk0x2q 464 11 critically critically RB cord-007796-zggk0x2q 464 12 depends depend VBZ cord-007796-zggk0x2q 464 13 on on IN cord-007796-zggk0x2q 464 14 timing timing NN cord-007796-zggk0x2q 464 15 of of IN cord-007796-zggk0x2q 464 16 challenges challenge NNS cord-007796-zggk0x2q 465 1 Pathophysiological pathophysiological JJ cord-007796-zggk0x2q 465 2 mechanisms mechanism NNS cord-007796-zggk0x2q 465 3 for for IN cord-007796-zggk0x2q 465 4 the the DT cord-007796-zggk0x2q 465 5 respiratory respiratory JJ cord-007796-zggk0x2q 465 6 syncytial syncytial JJ cord-007796-zggk0x2q 465 7 virus virus NN cord-007796-zggk0x2q 465 8 - - HYPH cord-007796-zggk0x2q 465 9 reactive reactive JJ cord-007796-zggk0x2q 465 10 airway airway NN cord-007796-zggk0x2q 465 11 disease disease NN cord-007796-zggk0x2q 465 12 link link VBP cord-007796-zggk0x2q 465 13 Respiratory respiratory JJ cord-007796-zggk0x2q 465 14 syncytial syncytial JJ cord-007796-zggk0x2q 465 15 virus virus NN cord-007796-zggk0x2q 465 16 and and CC cord-007796-zggk0x2q 465 17 subsequent subsequent JJ cord-007796-zggk0x2q 465 18 asthma asthma NN cord-007796-zggk0x2q 465 19 : : : cord-007796-zggk0x2q 465 20 One one CD cord-007796-zggk0x2q 465 21 step step NN cord-007796-zggk0x2q 465 22 closer close RBR cord-007796-zggk0x2q 465 23 to to IN cord-007796-zggk0x2q 465 24 unravelling unravel VBG cord-007796-zggk0x2q 465 25 the the DT cord-007796-zggk0x2q 465 26 Gordian Gordian NNP cord-007796-zggk0x2q 465 27 knot knot NN cord-007796-zggk0x2q 465 28 ? ? . cord-007796-zggk0x2q 466 1 Eosinophil eosinophil JJ cord-007796-zggk0x2q 466 2 cationic cationic JJ cord-007796-zggk0x2q 466 3 protein protein NN cord-007796-zggk0x2q 466 4 in in IN cord-007796-zggk0x2q 466 5 infants infant NNS cord-007796-zggk0x2q 466 6 with with IN cord-007796-zggk0x2q 466 7 respiratory respiratory JJ cord-007796-zggk0x2q 466 8 syncytial syncytial JJ cord-007796-zggk0x2q 466 9 virus virus NN cord-007796-zggk0x2q 466 10 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 466 11 : : : cord-007796-zggk0x2q 467 1 Predictive predictive JJ cord-007796-zggk0x2q 467 2 value value NN cord-007796-zggk0x2q 467 3 for for IN cord-007796-zggk0x2q 467 4 subsequent subsequent JJ cord-007796-zggk0x2q 467 5 development development NN cord-007796-zggk0x2q 467 6 of of IN cord-007796-zggk0x2q 467 7 persistent persistent JJ cord-007796-zggk0x2q 467 8 wheezing wheeze VBG cord-007796-zggk0x2q 467 9 Are be VBP cord-007796-zggk0x2q 467 10 we -PRON- PRP cord-007796-zggk0x2q 467 11 ready ready JJ cord-007796-zggk0x2q 467 12 for for IN cord-007796-zggk0x2q 467 13 universal universal JJ cord-007796-zggk0x2q 467 14 influenza influenza NN cord-007796-zggk0x2q 467 15 vaccination vaccination NN cord-007796-zggk0x2q 467 16 in in IN cord-007796-zggk0x2q 467 17 paediatrics paediatric NNS cord-007796-zggk0x2q 467 18 ? ? . cord-007796-zggk0x2q 468 1 Concurrent concurrent JJ cord-007796-zggk0x2q 468 2 serious serious JJ cord-007796-zggk0x2q 468 3 bacterial bacterial JJ cord-007796-zggk0x2q 468 4 infections infection NNS cord-007796-zggk0x2q 468 5 in in IN cord-007796-zggk0x2q 468 6 2396 2396 CD cord-007796-zggk0x2q 468 7 infants infant NNS cord-007796-zggk0x2q 468 8 and and CC cord-007796-zggk0x2q 468 9 children child NNS cord-007796-zggk0x2q 468 10 hospitalized hospitalize VBN cord-007796-zggk0x2q 468 11 with with IN cord-007796-zggk0x2q 468 12 respiratory respiratory JJ cord-007796-zggk0x2q 468 13 syncytial syncytial JJ cord-007796-zggk0x2q 468 14 virus virus NN cord-007796-zggk0x2q 468 15 lower low JJR cord-007796-zggk0x2q 468 16 respiratory respiratory JJ cord-007796-zggk0x2q 468 17 tract tract NN cord-007796-zggk0x2q 468 18 infections infection NNS cord-007796-zggk0x2q 468 19 Specific specific JJ cord-007796-zggk0x2q 468 20 inhibition inhibition NN cord-007796-zggk0x2q 468 21 of of IN cord-007796-zggk0x2q 468 22 type type NN cord-007796-zggk0x2q 469 1 I -PRON- PRP cord-007796-zggk0x2q 469 2 interferon interferon RB cord-007796-zggk0x2q 469 3 signal signal VBP cord-007796-zggk0x2q 469 4 transduction transduction NN cord-007796-zggk0x2q 469 5 by by IN cord-007796-zggk0x2q 469 6 respiratory respiratory JJ cord-007796-zggk0x2q 469 7 syncytial syncytial JJ cord-007796-zggk0x2q 469 8 virus virus NN cord-007796-zggk0x2q 469 9 Viral viral JJ cord-007796-zggk0x2q 469 10 evolution evolution NN cord-007796-zggk0x2q 469 11 toward toward IN cord-007796-zggk0x2q 469 12 change change NN cord-007796-zggk0x2q 469 13 in in IN cord-007796-zggk0x2q 469 14 receptor receptor NN cord-007796-zggk0x2q 469 15 usage usage NN cord-007796-zggk0x2q 469 16 : : : cord-007796-zggk0x2q 469 17 Adaptation adaptation NN cord-007796-zggk0x2q 469 18 of of IN cord-007796-zggk0x2q 469 19 a a DT cord-007796-zggk0x2q 469 20 major major JJ cord-007796-zggk0x2q 469 21 group group NN cord-007796-zggk0x2q 469 22 human human JJ cord-007796-zggk0x2q 469 23 rhinovirus rhinovirus NN cord-007796-zggk0x2q 469 24 to to TO cord-007796-zggk0x2q 469 25 grow grow VB cord-007796-zggk0x2q 469 26 in in IN cord-007796-zggk0x2q 469 27 ICAM-1-negative icam-1-negative NN cord-007796-zggk0x2q 469 28 cells cell NNS cord-007796-zggk0x2q 469 29 Eosinophils Eosinophils NNP cord-007796-zggk0x2q 469 30 , , , cord-007796-zggk0x2q 469 31 eosinophil eosinophil JJ cord-007796-zggk0x2q 469 32 ribonucleases ribonuclease NNS cord-007796-zggk0x2q 469 33 , , , cord-007796-zggk0x2q 469 34 and and CC cord-007796-zggk0x2q 469 35 their -PRON- PRP$ cord-007796-zggk0x2q 469 36 role role NN cord-007796-zggk0x2q 469 37 in in IN cord-007796-zggk0x2q 469 38 host host NN cord-007796-zggk0x2q 469 39 defense defense NN cord-007796-zggk0x2q 469 40 against against IN cord-007796-zggk0x2q 469 41 respiratory respiratory JJ cord-007796-zggk0x2q 469 42 virus virus NN cord-007796-zggk0x2q 469 43 pathogens pathogen NNS cord-007796-zggk0x2q 469 44 Respiratory respiratory JJ cord-007796-zggk0x2q 469 45 syncytial syncytial JJ cord-007796-zggk0x2q 469 46 virus virus NN cord-007796-zggk0x2q 469 47 infection infection NN cord-007796-zggk0x2q 469 48 results result VBZ cord-007796-zggk0x2q 469 49 in in IN cord-007796-zggk0x2q 469 50 airway airway NN cord-007796-zggk0x2q 469 51 hyperresponsiveness hyperresponsiveness NNP cord-007796-zggk0x2q 469 52 and and CC cord-007796-zggk0x2q 469 53 enhanced enhance VBN cord-007796-zggk0x2q 469 54 airway airway NN cord-007796-zggk0x2q 469 55 sensitization sensitization NN cord-007796-zggk0x2q 469 56 to to IN cord-007796-zggk0x2q 469 57 allergen allergen NN cord-007796-zggk0x2q 469 58 Latency Latency NNP cord-007796-zggk0x2q 469 59 and and CC cord-007796-zggk0x2q 469 60 persistence persistence NN cord-007796-zggk0x2q 469 61 of of IN cord-007796-zggk0x2q 469 62 respiratory respiratory JJ cord-007796-zggk0x2q 469 63 syncytial syncytial JJ cord-007796-zggk0x2q 469 64 virus virus NN cord-007796-zggk0x2q 469 65 despite despite IN cord-007796-zggk0x2q 469 66 T T NNP cord-007796-zggk0x2q 469 67 cell cell NN cord-007796-zggk0x2q 469 68 immunity immunity NN cord-007796-zggk0x2q 470 1 IFNgamma IFNgamma NNP cord-007796-zggk0x2q 470 2 mediates mediate VBZ cord-007796-zggk0x2q 470 3 a a DT cord-007796-zggk0x2q 470 4 novel novel JJ cord-007796-zggk0x2q 470 5 antiviral antiviral JJ cord-007796-zggk0x2q 470 6 activity activity NN cord-007796-zggk0x2q 470 7 through through IN cord-007796-zggk0x2q 470 8 dynamic dynamic JJ cord-007796-zggk0x2q 470 9 modulation modulation NN cord-007796-zggk0x2q 470 10 of of IN cord-007796-zggk0x2q 470 11 TRAIL TRAIL NNP cord-007796-zggk0x2q 470 12 and and CC cord-007796-zggk0x2q 470 13 TRAIL TRAIL NNP cord-007796-zggk0x2q 470 14 receptor receptor NN cord-007796-zggk0x2q 470 15 expression expression NN cord-007796-zggk0x2q 471 1 Viral viral JJ cord-007796-zggk0x2q 471 2 infections infection NNS cord-007796-zggk0x2q 471 3 in in IN cord-007796-zggk0x2q 471 4 obstructive obstructive JJ cord-007796-zggk0x2q 471 5 airway airway NN cord-007796-zggk0x2q 471 6 diseases disease NNS cord-007796-zggk0x2q 471 7 Respiratory respiratory JJ cord-007796-zggk0x2q 471 8 syncytial syncytial JJ cord-007796-zggk0x2q 471 9 virus virus NN cord-007796-zggk0x2q 471 10 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 471 11 in in IN cord-007796-zggk0x2q 471 12 infancy infancy NN cord-007796-zggk0x2q 471 13 is be VBZ cord-007796-zggk0x2q 471 14 an an DT cord-007796-zggk0x2q 471 15 important important JJ cord-007796-zggk0x2q 471 16 risk risk NN cord-007796-zggk0x2q 471 17 factor factor NN cord-007796-zggk0x2q 471 18 for for IN cord-007796-zggk0x2q 471 19 asthma asthma NN cord-007796-zggk0x2q 471 20 and and CC cord-007796-zggk0x2q 471 21 allergy allergy NN cord-007796-zggk0x2q 471 22 at at IN cord-007796-zggk0x2q 471 23 age age NN cord-007796-zggk0x2q 471 24 7 7 CD cord-007796-zggk0x2q 472 1 How how WRB cord-007796-zggk0x2q 472 2 viruses virus NNS cord-007796-zggk0x2q 472 3 enter enter VBP cord-007796-zggk0x2q 472 4 animal animal NN cord-007796-zggk0x2q 472 5 cells cell NNS cord-007796-zggk0x2q 472 6 Respiratory respiratory JJ cord-007796-zggk0x2q 472 7 syncytial syncytial JJ cord-007796-zggk0x2q 472 8 virus virus NN cord-007796-zggk0x2q 472 9 bronchiolitis bronchiolitis NN cord-007796-zggk0x2q 472 10 : : : cord-007796-zggk0x2q 473 1 Disease disease NN cord-007796-zggk0x2q 473 2 severity severity NN cord-007796-zggk0x2q 473 3 , , , cord-007796-zggk0x2q 473 4 interleukin-8 interleukin-8 NNP cord-007796-zggk0x2q 473 5 , , , cord-007796-zggk0x2q 473 6 and and CC cord-007796-zggk0x2q 473 7 virus virus NN cord-007796-zggk0x2q 473 8 genotype genotype NN cord-007796-zggk0x2q 473 9 Respiratory respiratory JJ cord-007796-zggk0x2q 473 10 virus virus NN cord-007796-zggk0x2q 473 11 infections infection NNS cord-007796-zggk0x2q 473 12 in in IN cord-007796-zggk0x2q 473 13 the the DT cord-007796-zggk0x2q 473 14 immunocompromised immunocompromised JJ cord-007796-zggk0x2q 473 15 host host NN cord-007796-zggk0x2q 473 16 Suppression suppression NN cord-007796-zggk0x2q 473 17 of of IN cord-007796-zggk0x2q 473 18 the the DT cord-007796-zggk0x2q 473 19 induction induction NN cord-007796-zggk0x2q 473 20 of of IN cord-007796-zggk0x2q 473 21 alpha alpha NN cord-007796-zggk0x2q 473 22 , , , cord-007796-zggk0x2q 473 23 beta beta NN cord-007796-zggk0x2q 473 24 , , , cord-007796-zggk0x2q 473 25 and and CC cord-007796-zggk0x2q 473 26 gamma gamma NN cord-007796-zggk0x2q 473 27 interferons interferon NNS cord-007796-zggk0x2q 473 28 by by IN cord-007796-zggk0x2q 473 29 the the DT cord-007796-zggk0x2q 473 30 NS1 NS1 NNS cord-007796-zggk0x2q 473 31 and and CC cord-007796-zggk0x2q 473 32 NS2 NS2 NNP cord-007796-zggk0x2q 473 33 proteins protein NNS cord-007796-zggk0x2q 473 34 of of IN cord-007796-zggk0x2q 473 35 human human JJ cord-007796-zggk0x2q 473 36 respiratory respiratory JJ cord-007796-zggk0x2q 473 37 syncytial syncytial JJ cord-007796-zggk0x2q 473 38 virus virus NN cord-007796-zggk0x2q 473 39 in in IN cord-007796-zggk0x2q 473 40 human human JJ cord-007796-zggk0x2q 473 41 epithelial epithelial JJ cord-007796-zggk0x2q 473 42 cells cell NNS cord-007796-zggk0x2q 473 43 and and CC cord-007796-zggk0x2q 473 44 macrophages macrophage NNS cord-007796-zggk0x2q 473 45 Respiratory respiratory JJ cord-007796-zggk0x2q 473 46 syncytial syncytial JJ cord-007796-zggk0x2q 473 47 virus virus NN cord-007796-zggk0x2q 473 48 in in IN cord-007796-zggk0x2q 473 49 early early JJ cord-007796-zggk0x2q 473 50 life life NN cord-007796-zggk0x2q 473 51 and and CC cord-007796-zggk0x2q 473 52 risk risk NN cord-007796-zggk0x2q 473 53 of of IN cord-007796-zggk0x2q 473 54 wheeze wheeze NN cord-007796-zggk0x2q 473 55 and and CC cord-007796-zggk0x2q 473 56 allergy allergy NN cord-007796-zggk0x2q 473 57 by by IN cord-007796-zggk0x2q 473 58 age age NN cord-007796-zggk0x2q 473 59 13 13 CD cord-007796-zggk0x2q 473 60 years year NNS cord-007796-zggk0x2q 473 61 Respiratory respiratory JJ cord-007796-zggk0x2q 473 62 syncytial syncytial JJ cord-007796-zggk0x2q 473 63 virus virus NN cord-007796-zggk0x2q 473 64 epidemics epidemic NNS cord-007796-zggk0x2q 473 65 : : : cord-007796-zggk0x2q 474 1 The the DT cord-007796-zggk0x2q 474 2 ups up NNS cord-007796-zggk0x2q 474 3 and and CC cord-007796-zggk0x2q 474 4 downs down NNS cord-007796-zggk0x2q 474 5 of of IN cord-007796-zggk0x2q 474 6 a a DT cord-007796-zggk0x2q 474 7 seasonal seasonal JJ cord-007796-zggk0x2q 474 8 virus virus NN cord-007796-zggk0x2q 474 9 Respiratory respiratory JJ cord-007796-zggk0x2q 474 10 syncytial syncytial JJ cord-007796-zggk0x2q 474 11 virus virus NN cord-007796-zggk0x2q 474 12 enhances enhance VBZ cord-007796-zggk0x2q 474 13 the the DT cord-007796-zggk0x2q 474 14 expression expression NN cord-007796-zggk0x2q 474 15 of of IN cord-007796-zggk0x2q 474 16 CD11b CD11b NNS cord-007796-zggk0x2q 474 17 molecules molecule NNS cord-007796-zggk0x2q 474 18 and and CC cord-007796-zggk0x2q 474 19 the the DT cord-007796-zggk0x2q 474 20 generation generation NN cord-007796-zggk0x2q 474 21 of of IN cord-007796-zggk0x2q 474 22 superoxide superoxide NN cord-007796-zggk0x2q 474 23 anion anion NN cord-007796-zggk0x2q 474 24 by by IN cord-007796-zggk0x2q 474 25 human human JJ cord-007796-zggk0x2q 474 26 eosinophils eosinophil NNS cord-007796-zggk0x2q 474 27 primed prime VBN cord-007796-zggk0x2q 474 28 with with IN cord-007796-zggk0x2q 474 29 platelet platelet NN cord-007796-zggk0x2q 474 30 - - HYPH cord-007796-zggk0x2q 474 31 activating activate VBG cord-007796-zggk0x2q 474 32 factor factor NN cord-007796-zggk0x2q 474 33 Association Association NNP cord-007796-zggk0x2q 474 34 between between IN cord-007796-zggk0x2q 474 35 common common JJ cord-007796-zggk0x2q 474 36 Toll Toll NNP cord-007796-zggk0x2q 474 37 - - HYPH cord-007796-zggk0x2q 474 38 like like JJ cord-007796-zggk0x2q 474 39 receptor receptor NN cord-007796-zggk0x2q 474 40 4 4 CD cord-007796-zggk0x2q 474 41 mutations mutation NNS cord-007796-zggk0x2q 474 42 and and CC cord-007796-zggk0x2q 474 43 severe severe JJ cord-007796-zggk0x2q 474 44 respiratory respiratory JJ cord-007796-zggk0x2q 474 45 syncytial syncytial JJ cord-007796-zggk0x2q 474 46 virus virus NN cord-007796-zggk0x2q 474 47 disease disease NN cord-007796-zggk0x2q 474 48 Time Time NNP cord-007796-zggk0x2q 474 49 course course NN cord-007796-zggk0x2q 474 50 of of IN cord-007796-zggk0x2q 474 51 severe severe JJ cord-007796-zggk0x2q 474 52 respiratory respiratory JJ cord-007796-zggk0x2q 474 53 syncytial syncytial JJ cord-007796-zggk0x2q 474 54 virus virus NN cord-007796-zggk0x2q 474 55 infection infection NN cord-007796-zggk0x2q 474 56 in in IN cord-007796-zggk0x2q 474 57 mechanically mechanically RB cord-007796-zggk0x2q 474 58 ventilated ventilate VBN cord-007796-zggk0x2q 474 59 infants infant NNS cord-007796-zggk0x2q 474 60 Palivizumab Palivizumab NNP cord-007796-zggk0x2q 474 61 , , , cord-007796-zggk0x2q 474 62 a a DT cord-007796-zggk0x2q 474 63 humanized humanize VBN cord-007796-zggk0x2q 474 64 respiratory respiratory JJ cord-007796-zggk0x2q 474 65 syncytial syncytial JJ cord-007796-zggk0x2q 474 66 virus virus NN cord-007796-zggk0x2q 474 67 monoclonal monoclonal JJ cord-007796-zggk0x2q 474 68 antibody antibody NN cord-007796-zggk0x2q 474 69 , , , cord-007796-zggk0x2q 474 70 reduces reduce VBZ cord-007796-zggk0x2q 474 71 hospitalization hospitalization NN cord-007796-zggk0x2q 474 72 from from IN cord-007796-zggk0x2q 474 73 respiratory respiratory JJ cord-007796-zggk0x2q 474 74 syncytial syncytial JJ cord-007796-zggk0x2q 474 75 virus virus NN cord-007796-zggk0x2q 474 76 infection infection NN cord-007796-zggk0x2q 474 77 in in IN cord-007796-zggk0x2q 474 78 high high JJ cord-007796-zggk0x2q 474 79 - - HYPH cord-007796-zggk0x2q 474 80 risk risk NN cord-007796-zggk0x2q 474 81 infants infant NNS cord-007796-zggk0x2q 475 1 Respiratory respiratory JJ cord-007796-zggk0x2q 475 2 syncytial syncytial JJ cord-007796-zggk0x2q 475 3 virus virus NN cord-007796-zggk0x2q 475 4 inhibits inhibit VBZ cord-007796-zggk0x2q 475 5 apoptosis apoptosis NN cord-007796-zggk0x2q 475 6 and and CC cord-007796-zggk0x2q 475 7 induces induce VBZ cord-007796-zggk0x2q 475 8 NF nf NN cord-007796-zggk0x2q 475 9 - - HYPH cord-007796-zggk0x2q 475 10 kappa kappa NN cord-007796-zggk0x2q 475 11 B b NN cord-007796-zggk0x2q 475 12 activity activity NN cord-007796-zggk0x2q 475 13 through through IN cord-007796-zggk0x2q 475 14 a a DT cord-007796-zggk0x2q 475 15 phosphatidylinositol phosphatidylinositol JJ cord-007796-zggk0x2q 475 16 3-kinase 3-kinase CD cord-007796-zggk0x2q 475 17 - - HYPH cord-007796-zggk0x2q 475 18 dependent dependent JJ cord-007796-zggk0x2q 475 19 pathway pathway NN cord-007796-zggk0x2q 475 20 Identification identification NN cord-007796-zggk0x2q 475 21 of of IN cord-007796-zggk0x2q 475 22 NF NF NNP cord-007796-zggk0x2q 475 23 - - HYPH cord-007796-zggk0x2q 475 24 kappaB kappaB NNP cord-007796-zggk0x2q 475 25 - - HYPH cord-007796-zggk0x2q 475 26 dependent dependent JJ cord-007796-zggk0x2q 475 27 gene gene NN cord-007796-zggk0x2q 475 28 networks network NNS cord-007796-zggk0x2q 475 29 in in IN cord-007796-zggk0x2q 476 1 respiratory respiratory JJ cord-007796-zggk0x2q 476 2 syncytial syncytial JJ cord-007796-zggk0x2q 476 3 virus virus NN cord-007796-zggk0x2q 476 4 - - HYPH cord-007796-zggk0x2q 476 5 infected infect VBN cord-007796-zggk0x2q 476 6 cells cell NNS cord-007796-zggk0x2q 476 7 CX3C CX3C NNS cord-007796-zggk0x2q 476 8 chemokine chemokine NN cord-007796-zggk0x2q 476 9 mimicry mimicry NN cord-007796-zggk0x2q 476 10 by by IN cord-007796-zggk0x2q 476 11 respiratory respiratory JJ cord-007796-zggk0x2q 476 12 syncytial syncytial JJ cord-007796-zggk0x2q 476 13 virus virus NN cord-007796-zggk0x2q 476 14 G g NN cord-007796-zggk0x2q 476 15 glycoprotein glycoprotein NN cord-007796-zggk0x2q 476 16 Respiratory respiratory JJ cord-007796-zggk0x2q 476 17 syncytial syncytial JJ cord-007796-zggk0x2q 476 18 virus virus NN cord-007796-zggk0x2q 476 19 infection infection NN cord-007796-zggk0x2q 476 20 in in IN cord-007796-zggk0x2q 476 21 patients patient NNS cord-007796-zggk0x2q 476 22 with with IN cord-007796-zggk0x2q 476 23 phagocyte phagocyte NNP cord-007796-zggk0x2q 476 24 defects defect NNS cord-007796-zggk0x2q 477 1 A a DT cord-007796-zggk0x2q 477 2 newly newly RB cord-007796-zggk0x2q 477 3 discovered discover VBN cord-007796-zggk0x2q 477 4 human human JJ cord-007796-zggk0x2q 477 5 pneumovirus pneumovirus NNP cord-007796-zggk0x2q 477 6 isolated isolate VBN cord-007796-zggk0x2q 477 7 from from IN cord-007796-zggk0x2q 477 8 young young JJ cord-007796-zggk0x2q 477 9 children child NNS cord-007796-zggk0x2q 477 10 with with IN cord-007796-zggk0x2q 477 11 respiratory respiratory JJ cord-007796-zggk0x2q 477 12 tract tract NN cord-007796-zggk0x2q 477 13 disease disease NN cord-007796-zggk0x2q 478 1 An an DT cord-007796-zggk0x2q 478 2 update update NN cord-007796-zggk0x2q 478 3 on on IN cord-007796-zggk0x2q 478 4 the the DT cord-007796-zggk0x2q 478 5 pathophysiology pathophysiology NN cord-007796-zggk0x2q 478 6 of of IN cord-007796-zggk0x2q 478 7 rhinovirus rhinovirus NN cord-007796-zggk0x2q 478 8 upper upper JJ cord-007796-zggk0x2q 478 9 respiratory respiratory JJ cord-007796-zggk0x2q 478 10 tract tract NN cord-007796-zggk0x2q 478 11 infections infection NNS cord-007796-zggk0x2q 479 1 Viral viral JJ cord-007796-zggk0x2q 479 2 lower low JJR cord-007796-zggk0x2q 479 3 respiratory respiratory JJ cord-007796-zggk0x2q 479 4 tract tract NN cord-007796-zggk0x2q 479 5 infection infection NN cord-007796-zggk0x2q 479 6 in in IN cord-007796-zggk0x2q 479 7 infants infant NNS cord-007796-zggk0x2q 479 8 and and CC cord-007796-zggk0x2q 479 9 young young JJ cord-007796-zggk0x2q 479 10 children child NNS cord-007796-zggk0x2q 479 11 Replication replication NN cord-007796-zggk0x2q 479 12 and and CC cord-007796-zggk0x2q 479 13 clearance clearance NN cord-007796-zggk0x2q 479 14 of of IN cord-007796-zggk0x2q 479 15 respiratory respiratory JJ cord-007796-zggk0x2q 479 16 syncytial syncytial JJ cord-007796-zggk0x2q 479 17 virus virus NN cord-007796-zggk0x2q 479 18 : : : cord-007796-zggk0x2q 480 1 Apoptosis apoptosis NN cord-007796-zggk0x2q 480 2 is be VBZ cord-007796-zggk0x2q 480 3 an an DT cord-007796-zggk0x2q 480 4 important important JJ cord-007796-zggk0x2q 480 5 pathway pathway NN cord-007796-zggk0x2q 480 6 of of IN cord-007796-zggk0x2q 480 7 virus virus NN cord-007796-zggk0x2q 480 8 clearance clearance NN cord-007796-zggk0x2q 480 9 after after IN cord-007796-zggk0x2q 480 10 experimental experimental JJ cord-007796-zggk0x2q 480 11 infection infection NN cord-007796-zggk0x2q 480 12 with with IN cord-007796-zggk0x2q 480 13 bovine bovine JJ cord-007796-zggk0x2q 480 14 respiratory respiratory JJ cord-007796-zggk0x2q 480 15 syncytial syncytial JJ cord-007796-zggk0x2q 480 16 virus virus NN cord-007796-zggk0x2q 480 17 Viral viral JJ cord-007796-zggk0x2q 480 18 induction induction NN cord-007796-zggk0x2q 480 19 of of IN cord-007796-zggk0x2q 480 20 a a DT cord-007796-zggk0x2q 480 21 chronic chronic JJ cord-007796-zggk0x2q 480 22 asthma asthma NN cord-007796-zggk0x2q 480 23 phenotype phenotype NN cord-007796-zggk0x2q 480 24 and and CC cord-007796-zggk0x2q 480 25 genetic genetic JJ cord-007796-zggk0x2q 480 26 segregation segregation NN cord-007796-zggk0x2q 480 27 from from IN cord-007796-zggk0x2q 480 28 the the DT cord-007796-zggk0x2q 480 29 acute acute JJ cord-007796-zggk0x2q 480 30 response response NN cord-007796-zggk0x2q 481 1 The the DT cord-007796-zggk0x2q 481 2 interaction interaction NN cord-007796-zggk0x2q 481 3 of of IN cord-007796-zggk0x2q 481 4 neutrophils neutrophil NNS cord-007796-zggk0x2q 481 5 with with IN cord-007796-zggk0x2q 481 6 respiratory respiratory JJ cord-007796-zggk0x2q 481 7 epithelial epithelial JJ cord-007796-zggk0x2q 481 8 cells cell NNS cord-007796-zggk0x2q 481 9 in in IN cord-007796-zggk0x2q 481 10 viral viral JJ cord-007796-zggk0x2q 481 11 infection infection NN cord-007796-zggk0x2q 481 12 Respiratory respiratory JJ cord-007796-zggk0x2q 481 13 syncytial syncytial JJ cord-007796-zggk0x2q 481 14 virus virus NN cord-007796-zggk0x2q 481 15 - - HYPH cord-007796-zggk0x2q 481 16 specific specific JJ cord-007796-zggk0x2q 481 17 antibody antibody NN cord-007796-zggk0x2q 481 18 responses response NNS cord-007796-zggk0x2q 481 19 in in IN cord-007796-zggk0x2q 481 20 immunoglobulin immunoglobulin NN cord-007796-zggk0x2q 481 21 A a NN cord-007796-zggk0x2q 481 22 and and CC cord-007796-zggk0x2q 481 23 E E NNP cord-007796-zggk0x2q 481 24 isotypes isotypes NN cord-007796-zggk0x2q 481 25 to to IN cord-007796-zggk0x2q 481 26 the the DT cord-007796-zggk0x2q 481 27 F F NNP cord-007796-zggk0x2q 481 28 and and CC cord-007796-zggk0x2q 481 29 G g NN cord-007796-zggk0x2q 481 30 proteins protein NNS cord-007796-zggk0x2q 481 31 and and CC cord-007796-zggk0x2q 481 32 to to IN cord-007796-zggk0x2q 481 33 intact intact JJ cord-007796-zggk0x2q 481 34 virus virus NN cord-007796-zggk0x2q 481 35 after after IN cord-007796-zggk0x2q 481 36 natural natural JJ cord-007796-zggk0x2q 481 37 infection infection NN cord-007796-zggk0x2q 481 38 Community Community NNP cord-007796-zggk0x2q 481 39 respiratory respiratory JJ cord-007796-zggk0x2q 481 40 viruses virus NNS cord-007796-zggk0x2q 481 41 : : : cord-007796-zggk0x2q 482 1 Organ organ NN cord-007796-zggk0x2q 482 2 transplant transplant NN cord-007796-zggk0x2q 482 3 recipients recipient NNS cord-007796-zggk0x2q 482 4 Respiratory respiratory JJ cord-007796-zggk0x2q 482 5 outcomes outcome NNS cord-007796-zggk0x2q 482 6 in in IN cord-007796-zggk0x2q 482 7 high high JJ cord-007796-zggk0x2q 482 8 - - HYPH cord-007796-zggk0x2q 482 9 risk risk NN cord-007796-zggk0x2q 482 10 children child NNS cord-007796-zggk0x2q 483 1 7 7 CD cord-007796-zggk0x2q 483 2 to to TO cord-007796-zggk0x2q 483 3 10 10 CD cord-007796-zggk0x2q 483 4 years year NNS cord-007796-zggk0x2q 483 5 after after IN cord-007796-zggk0x2q 483 6 prophylaxis prophylaxis NN cord-007796-zggk0x2q 483 7 with with IN cord-007796-zggk0x2q 483 8 respiratory respiratory JJ cord-007796-zggk0x2q 483 9 syncytial syncytial JJ cord-007796-zggk0x2q 483 10 virus virus NN cord-007796-zggk0x2q 483 11 immune immune JJ cord-007796-zggk0x2q 483 12 globulin globulin NN cord-007796-zggk0x2q 483 13 Human Human NNP cord-007796-zggk0x2q 483 14 metapneumovirus metapneumovirus NNP cord-007796-zggk0x2q 483 15 and and CC cord-007796-zggk0x2q 483 16 lower low JJR cord-007796-zggk0x2q 483 17 respiratory respiratory JJ cord-007796-zggk0x2q 483 18 tract tract NN cord-007796-zggk0x2q 483 19 disease disease NN cord-007796-zggk0x2q 483 20 in in IN cord-007796-zggk0x2q 483 21 otherwise otherwise RB cord-007796-zggk0x2q 483 22 healthy healthy JJ cord-007796-zggk0x2q 483 23 infants infant NNS cord-007796-zggk0x2q 483 24 and and CC cord-007796-zggk0x2q 483 25 children child NNS cord-007796-zggk0x2q 483 26 Immune immune VBP cord-007796-zggk0x2q 483 27 responses response NNS cord-007796-zggk0x2q 483 28 to to IN cord-007796-zggk0x2q 483 29 adenoviruses adenovirus NNS cord-007796-zggk0x2q 483 30 : : : cord-007796-zggk0x2q 484 1 Viral viral JJ cord-007796-zggk0x2q 484 2 evasion evasion NN cord-007796-zggk0x2q 484 3 mechanisms mechanism NNS cord-007796-zggk0x2q 484 4 and and CC cord-007796-zggk0x2q 484 5 their -PRON- PRP$ cord-007796-zggk0x2q 484 6 implications implication NNS cord-007796-zggk0x2q 484 7 for for IN cord-007796-zggk0x2q 484 8 the the DT cord-007796-zggk0x2q 484 9 clinic clinic NN cord-007796-zggk0x2q 484 10 Paramyxoviridae Paramyxoviridae NNP cord-007796-zggk0x2q 484 11 use use VBP cord-007796-zggk0x2q 484 12 distinct distinct JJ cord-007796-zggk0x2q 484 13 virusspecific virusspecific NN cord-007796-zggk0x2q 484 14 mechanisms mechanism NNS cord-007796-zggk0x2q 484 15 to to TO cord-007796-zggk0x2q 484 16 circumvent circumvent VB cord-007796-zggk0x2q 484 17 the the DT cord-007796-zggk0x2q 484 18 interferon interferon NN cord-007796-zggk0x2q 484 19 response response NN cord-007796-zggk0x2q 484 20 Evidence evidence NN cord-007796-zggk0x2q 484 21 of of IN cord-007796-zggk0x2q 484 22 airborne airborne JJ cord-007796-zggk0x2q 484 23 transmission transmission NN cord-007796-zggk0x2q 484 24 of of IN cord-007796-zggk0x2q 484 25 the the DT cord-007796-zggk0x2q 484 26 severe severe JJ cord-007796-zggk0x2q 484 27 acute acute JJ cord-007796-zggk0x2q 484 28 respiratory respiratory JJ cord-007796-zggk0x2q 484 29 syndrome syndrome NN cord-007796-zggk0x2q 484 30 virus virus NN cord-007796-zggk0x2q 484 31 Contribution Contribution NNP cord-007796-zggk0x2q 484 32 of of IN cord-007796-zggk0x2q 484 33 influenza influenza NN cord-007796-zggk0x2q 484 34 and and CC cord-007796-zggk0x2q 484 35 respiratory respiratory JJ cord-007796-zggk0x2q 484 36 syncytial syncytial JJ cord-007796-zggk0x2q 484 37 virus virus NN cord-007796-zggk0x2q 484 38 to to IN cord-007796-zggk0x2q 484 39 community community NN cord-007796-zggk0x2q 484 40 cases case NNS cord-007796-zggk0x2q 484 41 of of IN cord-007796-zggk0x2q 484 42 influenza influenza NN cord-007796-zggk0x2q 484 43 - - HYPH cord-007796-zggk0x2q 484 44 like like JJ cord-007796-zggk0x2q 484 45 illness illness NN cord-007796-zggk0x2q 484 46 : : : cord-007796-zggk0x2q 485 1 An an DT cord-007796-zggk0x2q 485 2 observational observational JJ cord-007796-zggk0x2q 485 3 study study NN cord-007796-zggk0x2q 486 1 Impaired impair VBN cord-007796-zggk0x2q 486 2 innate innate JJ cord-007796-zggk0x2q 486 3 host host NN cord-007796-zggk0x2q 486 4 defense defense NN cord-007796-zggk0x2q 486 5 causes cause VBZ cord-007796-zggk0x2q 486 6 susceptibility susceptibility NN cord-007796-zggk0x2q 486 7 to to IN cord-007796-zggk0x2q 486 8 respiratory respiratory JJ cord-007796-zggk0x2q 486 9 virus virus NN cord-007796-zggk0x2q 486 10 infections infection NNS cord-007796-zggk0x2q 486 11 in in IN cord-007796-zggk0x2q 486 12 cystic cystic JJ cord-007796-zggk0x2q 486 13 fibrosis fibrosis NN cord-007796-zggk0x2q 486 14 is be VBZ cord-007796-zggk0x2q 486 15 likely likely JJ cord-007796-zggk0x2q 486 16 to to TO cord-007796-zggk0x2q 486 17 be be VB cord-007796-zggk0x2q 486 18 crucial crucial JJ cord-007796-zggk0x2q 486 19 to to IN cord-007796-zggk0x2q 486 20 the the DT cord-007796-zggk0x2q 486 21 improvement improvement NN cord-007796-zggk0x2q 486 22 of of IN cord-007796-zggk0x2q 486 23 immunotherapies immunotherapy NNS cord-007796-zggk0x2q 486 24 for for IN cord-007796-zggk0x2q 486 25 prevention prevention NN cord-007796-zggk0x2q 486 26 and and CC cord-007796-zggk0x2q 486 27 treatment treatment NN cord-007796-zggk0x2q 486 28 of of IN cord-007796-zggk0x2q 486 29 viral viral JJ cord-007796-zggk0x2q 486 30 respiratory respiratory JJ cord-007796-zggk0x2q 486 31 tract tract NN cord-007796-zggk0x2q 486 32 infections infection NNS cord-007796-zggk0x2q 486 33 . . .