id sid tid token lemma pos cord-007445-2folsh35 1 1 key key NN cord-007445-2folsh35 1 2 : : : cord-007445-2folsh35 2 1 cord-007445 cord-007445 NNP cord-007445-2folsh35 2 2 - - HYPH cord-007445-2folsh35 2 3 2folsh35 2folsh35 CD cord-007445-2folsh35 2 4 authors author NNS cord-007445-2folsh35 2 5 : : : cord-007445-2folsh35 2 6 Tuffaha Tuffaha NNP cord-007445-2folsh35 2 7 , , , cord-007445-2folsh35 2 8 Amjad Amjad NNP cord-007445-2folsh35 2 9 ; ; : cord-007445-2folsh35 2 10 Gern Gern NNP cord-007445-2folsh35 2 11 , , , cord-007445-2folsh35 2 12 James James NNP cord-007445-2folsh35 2 13 E. E. NNP cord-007445-2folsh35 2 14 ; ; : cord-007445-2folsh35 2 15 Lemanske Lemanske NNP cord-007445-2folsh35 2 16 , , , cord-007445-2folsh35 2 17 Robert Robert NNP cord-007445-2folsh35 2 18 F. F. NNP cord-007445-2folsh35 2 19 title title NN cord-007445-2folsh35 2 20 : : : cord-007445-2folsh35 2 21 THE the DT cord-007445-2folsh35 2 22 ROLE role NN cord-007445-2folsh35 2 23 OF of IN cord-007445-2folsh35 2 24 RESPIRATORY respiratory JJ cord-007445-2folsh35 2 25 VIRUSES virus NNS cord-007445-2folsh35 2 26 IN in IN cord-007445-2folsh35 2 27 ACUTE acute JJ cord-007445-2folsh35 2 28 AND and CC cord-007445-2folsh35 2 29 CHRONIC CHRONIC NNP cord-007445-2folsh35 2 30 ASTHMA ASTHMA NNP cord-007445-2folsh35 2 31 date date NN cord-007445-2folsh35 2 32 : : : cord-007445-2folsh35 2 33 2000 2000 CD cord-007445-2folsh35 2 34 - - HYPH cord-007445-2folsh35 2 35 06 06 CD cord-007445-2folsh35 2 36 - - HYPH cord-007445-2folsh35 2 37 01 01 CD cord-007445-2folsh35 2 38 journal journal NN cord-007445-2folsh35 2 39 : : : cord-007445-2folsh35 2 40 Clin Clin NNP cord-007445-2folsh35 2 41 Chest Chest NNP cord-007445-2folsh35 2 42 Med Med NNP cord-007445-2folsh35 2 43 DOI doi NN cord-007445-2folsh35 2 44 : : : cord-007445-2folsh35 2 45 10.1016 10.1016 CD cord-007445-2folsh35 2 46 / / SYM cord-007445-2folsh35 2 47 s0272 s0272 NNP cord-007445-2folsh35 2 48 - - HYPH cord-007445-2folsh35 2 49 5231(05)70267 5231(05)70267 NNP cord-007445-2folsh35 2 50 - - HYPH cord-007445-2folsh35 2 51 7 7 CD cord-007445-2folsh35 2 52 sha sha NNP cord-007445-2folsh35 2 53 : : : cord-007445-2folsh35 3 1 90ba8980a02245623c3b00a09d16eb95b5e17e75 90ba8980a02245623c3b00a09d16eb95b5e17e75 CD cord-007445-2folsh35 3 2 doc_id doc_id CD cord-007445-2folsh35 4 1 : : : cord-007445-2folsh35 4 2 7445 7445 CD cord-007445-2folsh35 4 3 cord_uid cord_uid NNS cord-007445-2folsh35 4 4 : : : cord-007445-2folsh35 4 5 2folsh35 2folsh35 CD cord-007445-2folsh35 4 6 Respiratory respiratory JJ cord-007445-2folsh35 4 7 tract tract NN cord-007445-2folsh35 4 8 infections infection NNS cord-007445-2folsh35 4 9 caused cause VBN cord-007445-2folsh35 4 10 by by IN cord-007445-2folsh35 4 11 viruses virus NNS cord-007445-2folsh35 4 12 , , , cord-007445-2folsh35 4 13 24 24 CD cord-007445-2folsh35 4 14 , , , cord-007445-2folsh35 4 15 70 70 CD cord-007445-2folsh35 4 16 chlamydia chlamydia NNS cord-007445-2folsh35 4 17 , , , cord-007445-2folsh35 4 18 18 18 CD cord-007445-2folsh35 4 19 , , , cord-007445-2folsh35 4 20 19 19 CD cord-007445-2folsh35 4 21 , , , cord-007445-2folsh35 4 22 43 43 CD cord-007445-2folsh35 4 23 , , , cord-007445-2folsh35 4 24 55 55 CD cord-007445-2folsh35 4 25 , , , cord-007445-2folsh35 4 26 116 116 CD cord-007445-2folsh35 4 27 and and CC cord-007445-2folsh35 4 28 mycoplasma(61 mycoplasma(61 NNP cord-007445-2folsh35 4 29 ) ) -RRB- cord-007445-2folsh35 4 30 have have VBP cord-007445-2folsh35 4 31 been be VBN cord-007445-2folsh35 4 32 implicated implicate VBN cord-007445-2folsh35 4 33 in in IN cord-007445-2folsh35 4 34 the the DT cord-007445-2folsh35 4 35 pathogenesis pathogenesis NN cord-007445-2folsh35 4 36 of of IN cord-007445-2folsh35 4 37 asthma asthma NN cord-007445-2folsh35 4 38 . . . cord-007445-2folsh35 5 1 Viruses virus NNS cord-007445-2folsh35 5 2 have have VBP cord-007445-2folsh35 5 3 been be VBN cord-007445-2folsh35 5 4 demonstrated demonstrate VBN cord-007445-2folsh35 5 5 to to TO cord-007445-2folsh35 5 6 be be VB cord-007445-2folsh35 5 7 associated associate VBN cord-007445-2folsh35 5 8 with with IN cord-007445-2folsh35 5 9 asthma asthma NN cord-007445-2folsh35 5 10 epidemiologically epidemiologically RB cord-007445-2folsh35 5 11 in in IN cord-007445-2folsh35 5 12 at at RB cord-007445-2folsh35 5 13 least least RBS cord-007445-2folsh35 5 14 two two CD cord-007445-2folsh35 5 15 ways way NNS cord-007445-2folsh35 5 16 ( ( -LRB- cord-007445-2folsh35 5 17 Fig Fig NNP cord-007445-2folsh35 5 18 . . NNP cord-007445-2folsh35 5 19 1 1 CD cord-007445-2folsh35 5 20 ) ) -RRB- cord-007445-2folsh35 5 21 . . . cord-007445-2folsh35 6 1 First first RB cord-007445-2folsh35 6 2 , , , cord-007445-2folsh35 6 3 during during IN cord-007445-2folsh35 6 4 infancy infancy NN cord-007445-2folsh35 6 5 , , , cord-007445-2folsh35 6 6 certain certain JJ cord-007445-2folsh35 6 7 viruses virus NNS cord-007445-2folsh35 6 8 have have VBP cord-007445-2folsh35 6 9 been be VBN cord-007445-2folsh35 6 10 implicated implicate VBN cord-007445-2folsh35 6 11 as as IN cord-007445-2folsh35 6 12 potentially potentially RB cord-007445-2folsh35 6 13 being be VBG cord-007445-2folsh35 6 14 responsible responsible JJ cord-007445-2folsh35 6 15 for for IN cord-007445-2folsh35 6 16 the the DT cord-007445-2folsh35 6 17 inception inception NN cord-007445-2folsh35 6 18 of of IN cord-007445-2folsh35 6 19 the the DT cord-007445-2folsh35 6 20 asthmatic asthmatic JJ cord-007445-2folsh35 6 21 phenotype phenotype NN cord-007445-2folsh35 6 22 . . . cord-007445-2folsh35 7 1 Second second RB cord-007445-2folsh35 7 2 , , , cord-007445-2folsh35 7 3 in in IN cord-007445-2folsh35 7 4 patients patient NNS cord-007445-2folsh35 7 5 , , , cord-007445-2folsh35 7 6 particularly particularly RB cord-007445-2folsh35 7 7 children child NNS cord-007445-2folsh35 7 8 , , , cord-007445-2folsh35 7 9 with with IN cord-007445-2folsh35 7 10 established establish VBN cord-007445-2folsh35 7 11 asthma asthma NN cord-007445-2folsh35 7 12 , , , cord-007445-2folsh35 7 13 viral viral JJ cord-007445-2folsh35 7 14 upper upper JJ cord-007445-2folsh35 7 15 respiratory respiratory JJ cord-007445-2folsh35 7 16 tract tract NN cord-007445-2folsh35 7 17 infections infection NNS cord-007445-2folsh35 7 18 play play VBP cord-007445-2folsh35 7 19 a a DT cord-007445-2folsh35 7 20 significant significant JJ cord-007445-2folsh35 7 21 role role NN cord-007445-2folsh35 7 22 in in IN cord-007445-2folsh35 7 23 producing produce VBG cord-007445-2folsh35 7 24 acute acute JJ cord-007445-2folsh35 7 25 exacerbations exacerbation NNS cord-007445-2folsh35 7 26 of of IN cord-007445-2folsh35 7 27 airway airway JJ cord-007445-2folsh35 7 28 obstruction obstruction NN cord-007445-2folsh35 7 29 that that WDT cord-007445-2folsh35 7 30 may may MD cord-007445-2folsh35 7 31 result result VB cord-007445-2folsh35 7 32 in in IN cord-007445-2folsh35 7 33 frequent frequent JJ cord-007445-2folsh35 7 34 outpatient outpatient NN cord-007445-2folsh35 7 35 visits visit NNS cord-007445-2folsh35 7 36 or or CC cord-007445-2folsh35 7 37 hospitalizations hospitalization NNS cord-007445-2folsh35 7 38 . . . cord-007445-2folsh35 8 1 24 24 CD cord-007445-2folsh35 8 2 , , , cord-007445-2folsh35 8 3 55 55 CD cord-007445-2folsh35 8 4 , , , cord-007445-2folsh35 8 5 56 56 CD cord-007445-2folsh35 8 6 , , , cord-007445-2folsh35 8 7 57 57 CD cord-007445-2folsh35 9 1 This this DT cord-007445-2folsh35 9 2 article article NN cord-007445-2folsh35 9 3 reviews review VBZ cord-007445-2folsh35 9 4 these these DT cord-007445-2folsh35 9 5 two two CD cord-007445-2folsh35 9 6 areas area NNS cord-007445-2folsh35 9 7 by by IN cord-007445-2folsh35 9 8 focusing focus VBG cord-007445-2folsh35 9 9 first first RB cord-007445-2folsh35 9 10 on on IN cord-007445-2folsh35 9 11 mechanisms mechanism NNS cord-007445-2folsh35 9 12 by by IN cord-007445-2folsh35 9 13 which which WDT cord-007445-2folsh35 9 14 virus virus NN cord-007445-2folsh35 9 15 infections infection NNS cord-007445-2folsh35 9 16 may may MD cord-007445-2folsh35 9 17 lead lead VB cord-007445-2folsh35 9 18 to to IN cord-007445-2folsh35 9 19 the the DT cord-007445-2folsh35 9 20 development development NN cord-007445-2folsh35 9 21 of of IN cord-007445-2folsh35 9 22 asthma asthma NN cord-007445-2folsh35 9 23 in in IN cord-007445-2folsh35 9 24 infants infant NNS cord-007445-2folsh35 9 25 and and CC cord-007445-2folsh35 9 26 children child NNS cord-007445-2folsh35 9 27 and and CC cord-007445-2folsh35 9 28 , , , cord-007445-2folsh35 9 29 second second JJ cord-007445-2folsh35 9 30 , , , cord-007445-2folsh35 9 31 on on IN cord-007445-2folsh35 9 32 mechanisms mechanism NNS cord-007445-2folsh35 9 33 by by IN cord-007445-2folsh35 9 34 which which WDT cord-007445-2folsh35 9 35 virus virus NN cord-007445-2folsh35 9 36 infections infection NNS cord-007445-2folsh35 9 37 may may MD cord-007445-2folsh35 9 38 produce produce VB cord-007445-2folsh35 9 39 acute acute JJ cord-007445-2folsh35 9 40 asthmatic asthmatic JJ cord-007445-2folsh35 9 41 symptoms symptom NNS cord-007445-2folsh35 9 42 in in IN cord-007445-2folsh35 9 43 patients patient NNS cord-007445-2folsh35 9 44 who who WP cord-007445-2folsh35 9 45 already already RB cord-007445-2folsh35 9 46 have have VBP cord-007445-2folsh35 9 47 established establish VBN cord-007445-2folsh35 9 48 disease disease NN cord-007445-2folsh35 9 49 . . . cord-007445-2folsh35 10 1 Respiratory respiratory JJ cord-007445-2folsh35 10 2 tract tract NN cord-007445-2folsh35 10 3 infections infection NNS cord-007445-2folsh35 10 4 caused cause VBN cord-007445-2folsh35 10 5 by by IN cord-007445-2folsh35 10 6 viruses,24 viruses,24 NNP cord-007445-2folsh35 10 7 , , , cord-007445-2folsh35 10 8 70 70 CD cord-007445-2folsh35 10 9 chlamydia chlamydia NNS cord-007445-2folsh35 10 10 , , , cord-007445-2folsh35 10 11 ' ' '' cord-007445-2folsh35 10 12 * * NFP cord-007445-2folsh35 10 13 , , , cord-007445-2folsh35 10 14 19 19 CD cord-007445-2folsh35 10 15 , , , cord-007445-2folsh35 10 16 43 43 CD cord-007445-2folsh35 11 1 * * NFP cord-007445-2folsh35 11 2 55 55 CD cord-007445-2folsh35 11 3 * * NFP cord-007445-2folsh35 11 4 116 116 CD cord-007445-2folsh35 11 5 and and CC cord-007445-2folsh35 11 6 myco myco NNP cord-007445-2folsh35 11 7 - - HYPH cord-007445-2folsh35 11 8 plasma6I plasma6I NNP cord-007445-2folsh35 11 9 have have VBP cord-007445-2folsh35 11 10 been be VBN cord-007445-2folsh35 11 11 implicated implicate VBN cord-007445-2folsh35 11 12 in in IN cord-007445-2folsh35 11 13 the the DT cord-007445-2folsh35 11 14 pathogenesis pathogenesis NN cord-007445-2folsh35 11 15 of of IN cord-007445-2folsh35 11 16 asthma asthma NN cord-007445-2folsh35 11 17 . . . cord-007445-2folsh35 12 1 Viruses virus NNS cord-007445-2folsh35 12 2 have have VBP cord-007445-2folsh35 12 3 been be VBN cord-007445-2folsh35 12 4 demonstrated demonstrate VBN cord-007445-2folsh35 12 5 to to TO cord-007445-2folsh35 12 6 be be VB cord-007445-2folsh35 12 7 associated associate VBN cord-007445-2folsh35 12 8 with with IN cord-007445-2folsh35 12 9 asthma asthma NN cord-007445-2folsh35 12 10 epidemiologically epidemiologically RB cord-007445-2folsh35 12 11 in in IN cord-007445-2folsh35 12 12 at at RB cord-007445-2folsh35 12 13 least least RBS cord-007445-2folsh35 12 14 two two CD cord-007445-2folsh35 12 15 ways way NNS cord-007445-2folsh35 12 16 ( ( -LRB- cord-007445-2folsh35 12 17 Fig fig NN cord-007445-2folsh35 12 18 . . . cord-007445-2folsh35 12 19 _SP cord-007445-2folsh35 13 1 1 1 LS cord-007445-2folsh35 13 2 ) ) -RRB- cord-007445-2folsh35 13 3 . . . cord-007445-2folsh35 14 1 First first RB cord-007445-2folsh35 14 2 , , , cord-007445-2folsh35 14 3 during during IN cord-007445-2folsh35 14 4 infancy infancy NN cord-007445-2folsh35 14 5 , , , cord-007445-2folsh35 14 6 certain certain JJ cord-007445-2folsh35 14 7 viruses virus NNS cord-007445-2folsh35 14 8 have have VBP cord-007445-2folsh35 14 9 been be VBN cord-007445-2folsh35 14 10 implicated implicate VBN cord-007445-2folsh35 14 11 as as IN cord-007445-2folsh35 14 12 potentially potentially RB cord-007445-2folsh35 14 13 being be VBG cord-007445-2folsh35 14 14 responsible responsible JJ cord-007445-2folsh35 14 15 for for IN cord-007445-2folsh35 14 16 the the DT cord-007445-2folsh35 14 17 inception inception NN cord-007445-2folsh35 14 18 of of IN cord-007445-2folsh35 14 19 the the DT cord-007445-2folsh35 14 20 asthmatic asthmatic JJ cord-007445-2folsh35 14 21 phenotype phenotype NN cord-007445-2folsh35 14 22 . . . cord-007445-2folsh35 15 1 Second second RB cord-007445-2folsh35 15 2 , , , cord-007445-2folsh35 15 3 in in IN cord-007445-2folsh35 15 4 patients patient NNS cord-007445-2folsh35 15 5 , , , cord-007445-2folsh35 15 6 particularly particularly RB cord-007445-2folsh35 15 7 children child NNS cord-007445-2folsh35 15 8 , , , cord-007445-2folsh35 15 9 with with IN cord-007445-2folsh35 15 10 established establish VBN cord-007445-2folsh35 15 11 asthma asthma NN cord-007445-2folsh35 15 12 , , , cord-007445-2folsh35 15 13 viral viral JJ cord-007445-2folsh35 15 14 upper upper JJ cord-007445-2folsh35 15 15 respiratory respiratory JJ cord-007445-2folsh35 15 16 tract tract NN cord-007445-2folsh35 15 17 infections infection NNS cord-007445-2folsh35 15 18 play play VBP cord-007445-2folsh35 15 19 a a DT cord-007445-2folsh35 15 20 significant significant JJ cord-007445-2folsh35 15 21 role role NN cord-007445-2folsh35 15 22 in in IN cord-007445-2folsh35 15 23 producing produce VBG cord-007445-2folsh35 15 24 acute acute JJ cord-007445-2folsh35 15 25 exacerbations exacerbation NNS cord-007445-2folsh35 15 26 of of IN cord-007445-2folsh35 15 27 airway airway JJ cord-007445-2folsh35 15 28 obstruction obstruction NN cord-007445-2folsh35 15 29 that that WDT cord-007445-2folsh35 15 30 may may MD cord-007445-2folsh35 15 31 result result VB cord-007445-2folsh35 15 32 in in IN cord-007445-2folsh35 15 33 frequent frequent JJ cord-007445-2folsh35 15 34 outpatient outpatient NN cord-007445-2folsh35 15 35 visits visit NNS cord-007445-2folsh35 15 36 or or CC cord-007445-2folsh35 15 37 hospitalization^.^^ hospitalization^.^^ NN cord-007445-2folsh35 15 38 , , , cord-007445-2folsh35 15 39 [ [ -LRB- cord-007445-2folsh35 15 40 55 55 CD cord-007445-2folsh35 15 41 ] ] -RRB- cord-007445-2folsh35 16 1 [ [ -LRB- cord-007445-2folsh35 16 2 56 56 CD cord-007445-2folsh35 16 3 ] ] -RRB- cord-007445-2folsh35 17 1 [ [ -LRB- cord-007445-2folsh35 17 2 57 57 CD cord-007445-2folsh35 17 3 ] ] -RRB- cord-007445-2folsh35 18 1 This this DT cord-007445-2folsh35 18 2 article article NN cord-007445-2folsh35 18 3 reviews review VBZ cord-007445-2folsh35 18 4 these these DT cord-007445-2folsh35 18 5 two two CD cord-007445-2folsh35 18 6 areas area NNS cord-007445-2folsh35 18 7 by by IN cord-007445-2folsh35 18 8 focusing focus VBG cord-007445-2folsh35 18 9 first first RB cord-007445-2folsh35 18 10 on on IN cord-007445-2folsh35 18 11 mechanisms mechanism NNS cord-007445-2folsh35 18 12 by by IN cord-007445-2folsh35 18 13 which which WDT cord-007445-2folsh35 18 14 virus virus NN cord-007445-2folsh35 18 15 infections infection NNS cord-007445-2folsh35 18 16 may may MD cord-007445-2folsh35 18 17 lead lead VB cord-007445-2folsh35 18 18 to to IN cord-007445-2folsh35 18 19 the the DT cord-007445-2folsh35 18 20 development development NN cord-007445-2folsh35 18 21 of of IN cord-007445-2folsh35 18 22 asthma asthma NN cord-007445-2folsh35 18 23 in in IN cord-007445-2folsh35 18 24 infants infant NNS cord-007445-2folsh35 18 25 and and CC cord-007445-2folsh35 18 26 children child NNS cord-007445-2folsh35 18 27 and and CC cord-007445-2folsh35 18 28 , , , cord-007445-2folsh35 18 29 second second JJ cord-007445-2folsh35 18 30 , , , cord-007445-2folsh35 18 31 on on IN cord-007445-2folsh35 18 32 mechanisms mechanism NNS cord-007445-2folsh35 18 33 by by IN cord-007445-2folsh35 18 34 which which WDT cord-007445-2folsh35 18 35 virus virus NN cord-007445-2folsh35 18 36 infections infection NNS cord-007445-2folsh35 18 37 may may MD cord-007445-2folsh35 18 38 produce produce VB cord-007445-2folsh35 18 39 acute acute JJ cord-007445-2folsh35 18 40 asthmatic asthmatic JJ cord-007445-2folsh35 18 41 symptoms symptom NNS cord-007445-2folsh35 18 42 in in IN cord-007445-2folsh35 18 43 patients patient NNS cord-007445-2folsh35 18 44 who who WP cord-007445-2folsh35 18 45 already already RB cord-007445-2folsh35 18 46 have have VBP cord-007445-2folsh35 18 47 established establish VBN cord-007445-2folsh35 18 48 disease disease NN cord-007445-2folsh35 18 49 . . . cord-007445-2folsh35 19 1 Supported support VBN cord-007445-2folsh35 19 2 by by IN cord-007445-2folsh35 19 3 NIH NIH NNP cord-007445-2folsh35 19 4 Grants Grants NNP cord-007445-2folsh35 19 5 A134891 A134891 NNP cord-007445-2folsh35 19 6 , , , cord-007445-2folsh35 19 7 HL56396 hl56396 NN cord-007445-2folsh35 19 8 , , , cord-007445-2folsh35 19 9 and and CC cord-007445-2folsh35 19 10 lROlHL61879 lROlHL61879 NNP cord-007445-2folsh35 19 11 . . . cord-007445-2folsh35 20 1 Infections infection NNS cord-007445-2folsh35 20 2 with with IN cord-007445-2folsh35 20 3 respiratory respiratory JJ cord-007445-2folsh35 20 4 syncytial syncytial JJ cord-007445-2folsh35 20 5 virus virus NN cord-007445-2folsh35 20 6 ( ( -LRB- cord-007445-2folsh35 20 7 RSV RSV NNP cord-007445-2folsh35 20 8 ) ) -RRB- cord-007445-2folsh35 20 9 or or CC cord-007445-2folsh35 20 10 parainfluenza parainfluenza NNP cord-007445-2folsh35 20 11 virus virus NNP cord-007445-2folsh35 20 12 ( ( -LRB- cord-007445-2folsh35 20 13 PIV PIV NNP cord-007445-2folsh35 20 14 ) ) -RRB- cord-007445-2folsh35 20 15 have have VBP cord-007445-2folsh35 20 16 received receive VBN cord-007445-2folsh35 20 17 much much JJ cord-007445-2folsh35 20 18 attention attention NN cord-007445-2folsh35 20 19 because because IN cord-007445-2folsh35 20 20 of of IN cord-007445-2folsh35 20 21 their -PRON- PRP$ cord-007445-2folsh35 20 22 predilection predilection NN cord-007445-2folsh35 20 23 to to TO cord-007445-2folsh35 20 24 produce produce VB cord-007445-2folsh35 20 25 a a DT cord-007445-2folsh35 20 26 pattern pattern NN cord-007445-2folsh35 20 27 of of IN cord-007445-2folsh35 20 28 symptoms symptom NNS cord-007445-2folsh35 20 29 termed term VBN cord-007445-2folsh35 20 30 bronchioZitis bronchiozitis RB cord-007445-2folsh35 20 31 that that WDT cord-007445-2folsh35 20 32 parallels parallel VBZ cord-007445-2folsh35 20 33 many many JJ cord-007445-2folsh35 20 34 of of IN cord-007445-2folsh35 20 35 the the DT cord-007445-2folsh35 20 36 features feature NNS cord-007445-2folsh35 20 37 of of IN cord-007445-2folsh35 20 38 childhood childhood NN cord-007445-2folsh35 20 39 and and CC cord-007445-2folsh35 20 40 adult adult NN cord-007445-2folsh35 20 41 asthma.67 asthma.67 NNP cord-007445-2folsh35 20 42 Respiratory respiratory JJ cord-007445-2folsh35 20 43 syncytial syncytial JJ cord-007445-2folsh35 20 44 virus virus NN cord-007445-2folsh35 20 45 causes cause VBZ cord-007445-2folsh35 20 46 about about RB cord-007445-2folsh35 20 47 70 70 CD cord-007445-2folsh35 20 48 % % NN cord-007445-2folsh35 20 49 of of IN cord-007445-2folsh35 20 50 these these DT cord-007445-2folsh35 20 51 episodes episode NNS cord-007445-2folsh35 20 52 and and CC cord-007445-2folsh35 20 53 it -PRON- PRP cord-007445-2folsh35 20 54 is be VBZ cord-007445-2folsh35 20 55 estimated estimate VBN cord-007445-2folsh35 20 56 that that IN cord-007445-2folsh35 20 57 , , , cord-007445-2folsh35 20 58 by by IN cord-007445-2folsh35 20 59 age age NN cord-007445-2folsh35 20 60 1 1 CD cord-007445-2folsh35 20 61 year year NN cord-007445-2folsh35 20 62 , , , cord-007445-2folsh35 20 63 50 50 CD cord-007445-2folsh35 20 64 % % NN cord-007445-2folsh35 20 65 to to IN cord-007445-2folsh35 20 66 65 65 CD cord-007445-2folsh35 20 67 % % NN cord-007445-2folsh35 20 68 of of IN cord-007445-2folsh35 20 69 children child NNS cord-007445-2folsh35 20 70 will will MD cord-007445-2folsh35 20 71 have have VB cord-007445-2folsh35 20 72 been be VBN cord-007445-2folsh35 20 73 infected infect VBN cord-007445-2folsh35 20 74 with with IN cord-007445-2folsh35 20 75 this this DT cord-007445-2folsh35 20 76 virusn virusn NN cord-007445-2folsh35 20 77 and and CC cord-007445-2folsh35 20 78 40 40 CD cord-007445-2folsh35 20 79 % % NN cord-007445-2folsh35 20 80 of of IN cord-007445-2folsh35 20 81 these these DT cord-007445-2folsh35 20 82 infections infection NNS cord-007445-2folsh35 20 83 involve involve VBP cord-007445-2folsh35 20 84 the the DT cord-007445-2folsh35 20 85 lower low JJR cord-007445-2folsh35 20 86 respiratory respiratory JJ cord-007445-2folsh35 20 87 tract.92 tract.92 NN cord-007445-2folsh35 20 88 By by IN cord-007445-2folsh35 20 89 age age NN cord-007445-2folsh35 20 90 2 2 CD cord-007445-2folsh35 20 91 , , , cord-007445-2folsh35 20 92 nearly nearly RB cord-007445-2folsh35 20 93 all all DT cord-007445-2folsh35 20 94 children child NNS cord-007445-2folsh35 20 95 will will MD cord-007445-2folsh35 20 96 have have VB cord-007445-2folsh35 20 97 been be VBN cord-007445-2folsh35 20 98 infected infect VBN cord-007445-2folsh35 20 99 with with IN cord-007445-2folsh35 20 100 RSV RSV NNP cord-007445-2folsh35 20 101 at at IN cord-007445-2folsh35 20 102 least least JJS cord-007445-2folsh35 20 103 once once RB cord-007445-2folsh35 20 104 . . . cord-007445-2folsh35 21 1 Children child NNS cord-007445-2folsh35 21 2 aged age VBN cord-007445-2folsh35 21 3 3 3 CD cord-007445-2folsh35 21 4 to to TO cord-007445-2folsh35 21 5 6 6 CD cord-007445-2folsh35 21 6 months month NNS cord-007445-2folsh35 21 7 are be VBP cord-007445-2folsh35 21 8 most most RBS cord-007445-2folsh35 21 9 prone prone JJ cord-007445-2folsh35 21 10 to to TO cord-007445-2folsh35 21 11 develop develop VB cord-007445-2folsh35 21 12 lower low JJR cord-007445-2folsh35 21 13 respiratory respiratory JJ cord-007445-2folsh35 21 14 tract tract NN cord-007445-2folsh35 21 15 symptoms symptom NNS cord-007445-2folsh35 21 16 , , , cord-007445-2folsh35 21 17 suggesting suggest VBG cord-007445-2folsh35 21 18 that that IN cord-007445-2folsh35 21 19 a a DT cord-007445-2folsh35 21 20 developmental developmental JJ cord-007445-2folsh35 21 21 component component NN cord-007445-2folsh35 21 22 ( ( -LRB- cord-007445-2folsh35 21 23 e.g. e.g. RB cord-007445-2folsh35 21 24 , , , cord-007445-2folsh35 21 25 lung lung NN cord-007445-2folsh35 21 26 or or CC cord-007445-2folsh35 21 27 immunologic immunologic JJ cord-007445-2folsh35 21 28 maturation maturation NN cord-007445-2folsh35 21 29 ) ) -RRB- cord-007445-2folsh35 21 30 may may MD cord-007445-2folsh35 21 31 be be VB cord-007445-2folsh35 21 32 involved involve VBN cord-007445-2folsh35 21 33 as as IN cord-007445-2folsh35 21 34 83 83 CD cord-007445-2folsh35 22 1 The the DT cord-007445-2folsh35 22 2 relationship relationship NN cord-007445-2folsh35 22 3 between between IN cord-007445-2folsh35 22 4 RSV RSV NNP cord-007445-2folsh35 22 5 infections infection NNS cord-007445-2folsh35 22 6 during during IN cord-007445-2folsh35 22 7 the the DT cord-007445-2folsh35 22 8 first first JJ cord-007445-2folsh35 22 9 few few JJ cord-007445-2folsh35 22 10 years year NNS cord-007445-2folsh35 22 11 of of IN cord-007445-2folsh35 22 12 life life NN cord-007445-2folsh35 22 13 and and CC cord-007445-2folsh35 22 14 the the DT cord-007445-2folsh35 22 15 subsequent subsequent JJ cord-007445-2folsh35 22 16 development development NN cord-007445-2folsh35 22 17 of of IN cord-007445-2folsh35 22 18 the the DT cord-007445-2folsh35 22 19 asthmatic asthmatic JJ cord-007445-2folsh35 22 20 phenotype phenotype NN cord-007445-2folsh35 22 21 has have VBZ cord-007445-2folsh35 22 22 been be VBN cord-007445-2folsh35 22 23 the the DT cord-007445-2folsh35 22 24 subject subject NN cord-007445-2folsh35 22 25 of of IN cord-007445-2folsh35 22 26 much much JJ cord-007445-2folsh35 22 27 interest interest NN cord-007445-2folsh35 22 28 as as RB cord-007445-2folsh35 22 29 well well RB cord-007445-2folsh35 22 30 as as IN cord-007445-2folsh35 22 31 controversy controversy NN cord-007445-2folsh35 22 32 . . . cord-007445-2folsh35 23 1 Variations variation NNS cord-007445-2folsh35 23 2 in in IN cord-007445-2folsh35 23 3 reporting report VBG cord-007445-2folsh35 23 4 longitudinal longitudinal JJ cord-007445-2folsh35 23 5 outcomes outcome NNS cord-007445-2folsh35 23 6 ( ( -LRB- cord-007445-2folsh35 23 7 e.g. e.g. RB cord-007445-2folsh35 23 8 , , , cord-007445-2folsh35 23 9 recurrent recurrent JJ cord-007445-2folsh35 23 10 wheezing wheezing NN cord-007445-2folsh35 23 11 , , , cord-007445-2folsh35 23 12 measurements measurement NNS cord-007445-2folsh35 23 13 of of IN cord-007445-2folsh35 23 14 airway airway NNP cord-007445-2folsh35 23 15 hyperresponsiveness hyperresponsiveness NNP cord-007445-2folsh35 23 16 , , , cord-007445-2folsh35 23 17 diagnosis diagnosis NN cord-007445-2folsh35 23 18 of of IN cord-007445-2folsh35 23 19 asthma asthma NN cord-007445-2folsh35 23 20 ) ) -RRB- cord-007445-2folsh35 23 21 appear appear VBP cord-007445-2folsh35 23 22 to to TO cord-007445-2folsh35 23 23 be be VB cord-007445-2folsh35 23 24 influenced influence VBN cord-007445-2folsh35 23 25 mostly mostly RB cord-007445-2folsh35 23 26 by by IN cord-007445-2folsh35 23 27 the the DT cord-007445-2folsh35 23 28 criteria criterion NNS cord-007445-2folsh35 23 29 used use VBN cord-007445-2folsh35 23 30 to to TO cord-007445-2folsh35 23 31 define define VB cord-007445-2folsh35 23 32 " " `` cord-007445-2folsh35 23 33 bronchiolitis bronchiolitis NN cord-007445-2folsh35 23 34 . . . cord-007445-2folsh35 24 1 " " '' cord-007445-2folsh35 25 1 These these DT cord-007445-2folsh35 25 2 criteria criterion NNS cord-007445-2folsh35 25 3 include include VBP cord-007445-2folsh35 25 4 the the DT cord-007445-2folsh35 25 5 type type NN cord-007445-2folsh35 25 6 of of IN cord-007445-2folsh35 25 7 virus virus NN cord-007445-2folsh35 25 8 producing produce VBG cord-007445-2folsh35 25 9 the the DT cord-007445-2folsh35 25 10 symptoms symptom NNS cord-007445-2folsh35 25 11 ( ( -LRB- cord-007445-2folsh35 25 12 in in IN cord-007445-2folsh35 25 13 addition addition NN cord-007445-2folsh35 25 14 to to IN cord-007445-2folsh35 25 15 RSV RSV NNP cord-007445-2folsh35 25 16 , , , cord-007445-2folsh35 25 17 viruses virus NNS cord-007445-2folsh35 25 18 that that WDT cord-007445-2folsh35 25 19 may may MD cord-007445-2folsh35 25 20 contribute contribute VB cord-007445-2folsh35 25 21 to to IN cord-007445-2folsh35 25 22 the the DT cord-007445-2folsh35 25 23 development development NN cord-007445-2folsh35 25 24 of of IN cord-007445-2folsh35 25 25 bronchiolitis bronchiolitis NN cord-007445-2folsh35 25 26 in in IN cord-007445-2folsh35 25 27 this this DT cord-007445-2folsh35 25 28 age age NN cord-007445-2folsh35 25 29 group group NN cord-007445-2folsh35 25 30 could could MD cord-007445-2folsh35 25 31 be be VB cord-007445-2folsh35 25 32 PIV PIV NNP cord-007445-2folsh35 25 33 , , , cord-007445-2folsh35 25 34 coronavirus coronavirus NN cord-007445-2folsh35 25 35 , , , cord-007445-2folsh35 25 36 influenzavirus influenzavirus NN cord-007445-2folsh35 25 37 , , , cord-007445-2folsh35 25 38 and and CC cord-007445-2folsh35 25 39 rhin rhin NNP cord-007445-2folsh35 25 40 ~ ~ NFP cord-007445-2folsh35 25 41 virus~~ virus~~ NN cord-007445-2folsh35 25 42 ) ) -RRB- cord-007445-2folsh35 25 43 ; ; : cord-007445-2folsh35 25 44 the the DT cord-007445-2folsh35 25 45 age age NN cord-007445-2folsh35 25 46 at at IN cord-007445-2folsh35 25 47 the the DT cord-007445-2folsh35 25 48 time time NN cord-007445-2folsh35 25 49 of of IN cord-007445-2folsh35 25 50 infection infection NN cord-007445-2folsh35 25 51 ; ; : cord-007445-2folsh35 25 52 the the DT cord-007445-2folsh35 25 53 nature nature NN cord-007445-2folsh35 25 54 and and CC cord-007445-2folsh35 25 55 severity severity NN cord-007445-2folsh35 25 56 of of IN cord-007445-2folsh35 25 57 symptoms symptom NNS cord-007445-2folsh35 25 58 required require VBN cord-007445-2folsh35 25 59 for for IN cord-007445-2folsh35 25 60 inclusion inclusion NN cord-007445-2folsh35 25 61 ; ; : cord-007445-2folsh35 25 62 and and CC cord-007445-2folsh35 25 63 , , , cord-007445-2folsh35 25 64 finally finally RB cord-007445-2folsh35 25 65 , , , cord-007445-2folsh35 25 66 the the DT cord-007445-2folsh35 25 67 characteristics characteristic NNS cord-007445-2folsh35 25 68 of of IN cord-007445-2folsh35 25 69 both both CC cord-007445-2folsh35 25 70 the the DT cord-007445-2folsh35 25 71 study study NN cord-007445-2folsh35 25 72 population population NN cord-007445-2folsh35 25 73 ( ( -LRB- cord-007445-2folsh35 25 74 community community NN cord-007445-2folsh35 25 75 versus versus IN cord-007445-2folsh35 25 76 hospital hospital NN cord-007445-2folsh35 25 77 - - HYPH cord-007445-2folsh35 25 78 based base VBN cord-007445-2folsh35 25 79 ) ) -RRB- cord-007445-2folsh35 25 80 and and CC cord-007445-2folsh35 25 81 the the DT cord-007445-2folsh35 25 82 study study NN cord-007445-2folsh35 25 83 design design NN cord-007445-2folsh35 25 84 ( ( -LRB- cord-007445-2folsh35 25 85 retrospective retrospective JJ cord-007445-2folsh35 25 86 versus versus IN cord-007445-2folsh35 25 87 prospective prospective JJ cord-007445-2folsh35 25 88 ) ) -RRB- cord-007445-2folsh35 25 89 . . . cord-007445-2folsh35 26 1 A a DT cord-007445-2folsh35 26 2 number number NN cord-007445-2folsh35 26 3 of of IN cord-007445-2folsh35 26 4 long long JJ cord-007445-2folsh35 26 5 - - HYPH cord-007445-2folsh35 26 6 term term NN cord-007445-2folsh35 26 7 prospective prospective JJ cord-007445-2folsh35 26 8 studies study NNS cord-007445-2folsh35 26 9 of of IN cord-007445-2folsh35 26 10 children child NNS cord-007445-2folsh35 26 11 admitted admit VBD cord-007445-2folsh35 26 12 to to IN cord-007445-2folsh35 26 13 a a DT cord-007445-2folsh35 26 14 hospital hospital NN cord-007445-2folsh35 26 15 with with IN cord-007445-2folsh35 26 16 documented document VBN cord-007445-2folsh35 26 17 RSV RSV NNP cord-007445-2folsh35 26 18 - - HYPH cord-007445-2folsh35 26 19 induced induce VBN cord-007445-2folsh35 26 20 bronchiolitis bronchiolitis NN cord-007445-2folsh35 26 21 have have VBP cord-007445-2folsh35 26 22 shown show VBN cord-007445-2folsh35 26 23 that that IN cord-007445-2folsh35 26 24 about about RB cord-007445-2folsh35 26 25 75 75 CD cord-007445-2folsh35 26 26 % % NN cord-007445-2folsh35 26 27 experience experience NN cord-007445-2folsh35 26 28 wheezing wheeze VBG cord-007445-2folsh35 26 29 in in IN cord-007445-2folsh35 26 30 the the DT cord-007445-2folsh35 26 31 first first JJ cord-007445-2folsh35 26 32 2 2 CD cord-007445-2folsh35 26 33 years year NNS cord-007445-2folsh35 26 34 after after IN cord-007445-2folsh35 26 35 the the DT cord-007445-2folsh35 26 36 initial initial JJ cord-007445-2folsh35 26 37 illness illness NN cord-007445-2folsh35 26 38 , , , cord-007445-2folsh35 26 39 more more JJR cord-007445-2folsh35 26 40 than than IN cord-007445-2folsh35 26 41 50 50 CD cord-007445-2folsh35 26 42 % % NN cord-007445-2folsh35 26 43 still still RB cord-007445-2folsh35 26 44 wheeze wheeze VBP cord-007445-2folsh35 26 45 3 3 CD cord-007445-2folsh35 26 46 years year NNS cord-007445-2folsh35 26 47 later later RB cord-007445-2folsh35 26 48 , , , cord-007445-2folsh35 26 49 and and CC cord-007445-2folsh35 26 50 approximately approximately RB cord-007445-2folsh35 26 51 40 40 CD cord-007445-2folsh35 26 52 % % NN cord-007445-2folsh35 26 53 continue continue VBP cord-007445-2folsh35 26 54 to to TO cord-007445-2folsh35 26 55 wheeze wheeze VB cord-007445-2folsh35 26 56 after after IN cord-007445-2folsh35 26 57 5 5 CD cord-007445-2folsh35 26 58 years year NNS cord-007445-2folsh35 26 59 ? ? . cord-007445-2folsh35 26 60 , , , cord-007445-2folsh35 26 61 , , , cord-007445-2folsh35 26 62 49 49 CD cord-007445-2folsh35 26 63 , , , cord-007445-2folsh35 26 64 733 733 CD cord-007445-2folsh35 26 65 91 91 CD cord-007445-2folsh35 26 66 , , , cord-007445-2folsh35 26 67 117 117 CD cord-007445-2folsh35 26 68 , , , cord-007445-2folsh35 26 69 Additional additional JJ cord-007445-2folsh35 26 70 insight insight NN cord-007445-2folsh35 26 71 into into IN cord-007445-2folsh35 26 72 these these DT cord-007445-2folsh35 26 73 areas area NNS cord-007445-2folsh35 26 74 recently recently RB cord-007445-2folsh35 26 75 was be VBD cord-007445-2folsh35 26 76 provided provide VBN cord-007445-2folsh35 26 77 by by IN cord-007445-2folsh35 26 78 the the DT cord-007445-2folsh35 26 79 results result NNS cord-007445-2folsh35 26 80 of of IN cord-007445-2folsh35 26 81 an an DT cord-007445-2folsh35 26 82 ll ll JJ cord-007445-2folsh35 26 83 - - HYPH cord-007445-2folsh35 26 84 year year NN cord-007445-2folsh35 26 85 prospective prospective JJ cord-007445-2folsh35 26 86 study study NN cord-007445-2folsh35 26 87 involving involve VBG cord-007445-2folsh35 26 88 880 880 CD cord-007445-2folsh35 26 89 children child NNS cord-007445-2folsh35 26 90 who who WP cord-007445-2folsh35 26 91 were be VBD cord-007445-2folsh35 26 92 enrolled enrol VBN cord-007445-2folsh35 26 93 at at IN cord-007445-2folsh35 26 94 birth birth NN cord-007445-2folsh35 26 95 , , , cord-007445-2folsh35 26 96 followed follow VBN cord-007445-2folsh35 26 97 for for IN cord-007445-2folsh35 26 98 the the DT cord-007445-2folsh35 26 99 development development NN cord-007445-2folsh35 26 100 of of IN cord-007445-2folsh35 26 101 lower low JJR cord-007445-2folsh35 26 102 respiratory respiratory JJ cord-007445-2folsh35 26 103 tract tract NN cord-007445-2folsh35 26 104 illnesses illness NNS cord-007445-2folsh35 26 105 ( ( -LRB- cord-007445-2folsh35 26 106 LRIs LRIs NNP cord-007445-2folsh35 26 107 ) ) -RRB- cord-007445-2folsh35 26 108 in in IN cord-007445-2folsh35 26 109 the the DT cord-007445-2folsh35 26 110 first first JJ cord-007445-2folsh35 26 111 3 3 CD cord-007445-2folsh35 26 112 years year NNS cord-007445-2folsh35 26 113 of of IN cord-007445-2folsh35 26 114 life life NN cord-007445-2folsh35 26 115 , , , cord-007445-2folsh35 26 116 and and CC cord-007445-2folsh35 26 117 then then RB cord-007445-2folsh35 26 118 evaluated evaluate VBD cord-007445-2folsh35 26 119 for for IN cord-007445-2folsh35 26 120 the the DT cord-007445-2folsh35 26 121 presence presence NN cord-007445-2folsh35 26 122 or or CC cord-007445-2folsh35 26 123 absence absence NN cord-007445-2folsh35 26 124 of of IN cord-007445-2folsh35 26 125 physician physician NN cord-007445-2folsh35 26 126 - - HYPH cord-007445-2folsh35 26 127 diagnosed diagnose VBN cord-007445-2folsh35 26 128 asthma asthma NN cord-007445-2folsh35 26 129 or or CC cord-007445-2folsh35 26 130 a a DT cord-007445-2folsh35 26 131 history history NN cord-007445-2folsh35 26 132 of of IN cord-007445-2folsh35 26 133 current current JJ cord-007445-2folsh35 26 134 wheezing wheezing NN cord-007445-2folsh35 26 135 at at IN cord-007445-2folsh35 26 136 ages age NNS cord-007445-2folsh35 26 137 6 6 CD cord-007445-2folsh35 26 138 and and CC cord-007445-2folsh35 26 139 11 11 CD cord-007445-2folsh35 26 140 years.14 years.14 NNP cord-007445-2folsh35 27 1 Most most RBS cord-007445-2folsh35 27 2 importantly importantly RB cord-007445-2folsh35 27 3 , , , cord-007445-2folsh35 27 4 lung lung NN cord-007445-2folsh35 27 5 function function NN cord-007445-2folsh35 27 6 was be VBD cord-007445-2folsh35 27 7 evaluated evaluate VBN cord-007445-2folsh35 27 8 in in IN cord-007445-2folsh35 27 9 the the DT cord-007445-2folsh35 27 10 first first JJ cord-007445-2folsh35 27 11 few few JJ cord-007445-2folsh35 27 12 months month NNS cord-007445-2folsh35 27 13 of of IN cord-007445-2folsh35 27 14 life life NN cord-007445-2folsh35 27 15 in in IN cord-007445-2folsh35 27 16 a a DT cord-007445-2folsh35 27 17 subset subset NN cord-007445-2folsh35 27 18 of of IN cord-007445-2folsh35 27 19 these these DT cord-007445-2folsh35 27 20 children child NNS cord-007445-2folsh35 27 21 prior prior RB cord-007445-2folsh35 27 22 to to IN cord-007445-2folsh35 27 23 the the DT cord-007445-2folsh35 27 24 development development NN cord-007445-2folsh35 27 25 of of IN cord-007445-2folsh35 27 26 a a DT cord-007445-2folsh35 27 27 documented document VBN cord-007445-2folsh35 27 28 LRI lri NN cord-007445-2folsh35 27 29 . . . cord-007445-2folsh35 28 1 During during IN cord-007445-2folsh35 28 2 the the DT cord-007445-2folsh35 28 3 first first JJ cord-007445-2folsh35 28 4 3 3 CD cord-007445-2folsh35 28 5 years year NNS cord-007445-2folsh35 28 6 of of IN cord-007445-2folsh35 28 7 life life NN cord-007445-2folsh35 28 8 , , , cord-007445-2folsh35 28 9 7.4 7.4 CD cord-007445-2folsh35 28 10 % % NN cord-007445-2folsh35 28 11 had have VBD cord-007445-2folsh35 28 12 pneumonia pneumonia NN cord-007445-2folsh35 28 13 documented document VBN cord-007445-2folsh35 28 14 radio radio NN cord-007445-2folsh35 28 15 - - HYPH cord-007445-2folsh35 28 16 graphically graphically RB cord-007445-2folsh35 28 17 and and CC cord-007445-2folsh35 28 18 44.7 44.7 CD cord-007445-2folsh35 28 19 % % NN cord-007445-2folsh35 28 20 had have VBD cord-007445-2folsh35 28 21 a a DT cord-007445-2folsh35 28 22 significant significant JJ cord-007445-2folsh35 28 23 LRI lri NN cord-007445-2folsh35 28 24 without without IN cord-007445-2folsh35 28 25 pneumonia pneumonia NN cord-007445-2folsh35 28 26 . . . cord-007445-2folsh35 29 1 Respiratory respiratory JJ cord-007445-2folsh35 29 2 syncytial syncytial JJ cord-007445-2folsh35 29 3 virus virus NN cord-007445-2folsh35 29 4 and and CC cord-007445-2folsh35 29 5 PIV PIV NNP cord-007445-2folsh35 29 6 were be VBD cord-007445-2folsh35 29 7 identified identify VBN cord-007445-2folsh35 29 8 in in IN cord-007445-2folsh35 29 9 36.4 36.4 CD cord-007445-2folsh35 29 10 % % NN cord-007445-2folsh35 29 11 and and CC cord-007445-2folsh35 29 12 7.3 7.3 CD cord-007445-2folsh35 29 13 % % NN cord-007445-2folsh35 29 14 , , , cord-007445-2folsh35 29 15 respectively respectively RB cord-007445-2folsh35 29 16 , , , cord-007445-2folsh35 29 17 in in IN cord-007445-2folsh35 29 18 the the DT cord-007445-2folsh35 29 19 subjects subject NNS cord-007445-2folsh35 29 20 with with IN cord-007445-2folsh35 29 21 pneumonia pneumonia NN cord-007445-2folsh35 29 22 , , , cord-007445-2folsh35 29 23 and and CC cord-007445-2folsh35 29 24 in in IN cord-007445-2folsh35 29 25 35.6 35.6 CD cord-007445-2folsh35 29 26 % % NN cord-007445-2folsh35 29 27 and and CC cord-007445-2folsh35 29 28 15.2 15.2 CD cord-007445-2folsh35 29 29 % % NN cord-007445-2folsh35 29 30 , , , cord-007445-2folsh35 29 31 respectively respectively RB cord-007445-2folsh35 29 32 , , , cord-007445-2folsh35 29 33 of of IN cord-007445-2folsh35 29 34 the the DT cord-007445-2folsh35 29 35 subjects subject NNS cord-007445-2folsh35 29 36 with with IN cord-007445-2folsh35 29 37 a a DT cord-007445-2folsh35 29 38 LRI lri NN cord-007445-2folsh35 29 39 . . . cord-007445-2folsh35 30 1 At at IN cord-007445-2folsh35 30 2 age age NN cord-007445-2folsh35 30 3 6 6 CD cord-007445-2folsh35 30 4 , , , cord-007445-2folsh35 30 5 physiciandiagnosed physiciandiagnosed JJ cord-007445-2folsh35 30 6 asthma asthma NN cord-007445-2folsh35 30 7 was be VBD cord-007445-2folsh35 30 8 present present JJ cord-007445-2folsh35 30 9 in in IN cord-007445-2folsh35 30 10 13.6 13.6 CD cord-007445-2folsh35 30 11 % % NN cord-007445-2folsh35 30 12 ( ( -LRB- cord-007445-2folsh35 30 13 OR or CC cord-007445-2folsh35 30 14 = = SYM cord-007445-2folsh35 30 15 3.3 3.3 CD cord-007445-2folsh35 30 16 ) ) -RRB- cord-007445-2folsh35 30 17 , , , cord-007445-2folsh35 30 18 10.2 10.2 CD cord-007445-2folsh35 30 19 % % NN cord-007445-2folsh35 30 20 ( ( -LRB- cord-007445-2folsh35 30 21 OR or CC cord-007445-2folsh35 30 22 = = SYM cord-007445-2folsh35 30 23 2.4 2.4 CD cord-007445-2folsh35 30 24 ) ) -RRB- cord-007445-2folsh35 30 25 , , , cord-007445-2folsh35 30 26 and and CC cord-007445-2folsh35 30 27 4.6 4.6 CD cord-007445-2folsh35 30 28 % % NN cord-007445-2folsh35 30 29 of of IN cord-007445-2folsh35 30 30 the the DT cord-007445-2folsh35 30 31 subjects subject NNS cord-007445-2folsh35 30 32 with with IN cord-007445-2folsh35 30 33 pneumonia pneumonia NN cord-007445-2folsh35 30 34 , , , cord-007445-2folsh35 30 35 LRI LRI NNP cord-007445-2folsh35 30 36 , , , cord-007445-2folsh35 30 37 and and CC cord-007445-2folsh35 30 38 no no DT cord-007445-2folsh35 30 39 LRI lri NN cord-007445-2folsh35 30 40 , , , cord-007445-2folsh35 30 41 respectively respectively RB cord-007445-2folsh35 30 42 . . . cord-007445-2folsh35 31 1 By by IN cord-007445-2folsh35 31 2 age age NN cord-007445-2folsh35 31 3 11 11 CD cord-007445-2folsh35 31 4 , , , cord-007445-2folsh35 31 5 these these DT cord-007445-2folsh35 31 6 values value NNS cord-007445-2folsh35 31 7 increased increase VBD cord-007445-2folsh35 31 8 to to IN cord-007445-2folsh35 31 9 25.9 25.9 CD cord-007445-2folsh35 31 10 % % NN cord-007445-2folsh35 31 11 ( ( -LRB- cord-007445-2folsh35 31 12 OR or CC cord-007445-2folsh35 31 13 = = SYM cord-007445-2folsh35 31 14 2.8 2.8 CD cord-007445-2folsh35 31 15 ) ) -RRB- cord-007445-2folsh35 31 16 , , , cord-007445-2folsh35 31 17 16.1 16.1 CD cord-007445-2folsh35 31 18 % % NN cord-007445-2folsh35 31 19 ( ( -LRB- cord-007445-2folsh35 31 20 OR or CC cord-007445-2folsh35 31 21 = = SYM cord-007445-2folsh35 31 22 1.6 1.6 CD cord-007445-2folsh35 31 23 ) ) -RRB- cord-007445-2folsh35 31 24 , , , cord-007445-2folsh35 31 25 and and CC cord-007445-2folsh35 31 26 11 11 CD cord-007445-2folsh35 31 27 % % NN cord-007445-2folsh35 31 28 , , , cord-007445-2folsh35 31 29 respectively respectively RB cord-007445-2folsh35 31 30 . . . cord-007445-2folsh35 32 1 Mean mean JJ cord-007445-2folsh35 32 2 maximum maximum JJ cord-007445-2folsh35 32 3 volume volume NN cord-007445-2folsh35 32 4 at at IN cord-007445-2folsh35 32 5 functional functional JJ cord-007445-2folsh35 32 6 residual residual JJ cord-007445-2folsh35 32 7 capacity capacity NN cord-007445-2folsh35 32 8 values value NNS cord-007445-2folsh35 32 9 before before IN cord-007445-2folsh35 32 10 any any DT cord-007445-2folsh35 32 11 LRI LRI NNP cord-007445-2folsh35 32 12 were be VBD cord-007445-2folsh35 32 13 lower low JJR cord-007445-2folsh35 32 14 in in IN cord-007445-2folsh35 32 15 children child NNS cord-007445-2folsh35 32 16 with with IN cord-007445-2folsh35 32 17 pneumonia pneumonia NN cord-007445-2folsh35 32 18 and and CC cord-007445-2folsh35 32 19 with with IN cord-007445-2folsh35 32 20 LRIs lri NNS cord-007445-2folsh35 32 21 than than IN cord-007445-2folsh35 32 22 in in IN cord-007445-2folsh35 32 23 children child NNS cord-007445-2folsh35 32 24 with with IN cord-007445-2folsh35 32 25 no no DT cord-007445-2folsh35 32 26 LRIs lris NN cord-007445-2folsh35 32 27 . . . cord-007445-2folsh35 33 1 These these DT cord-007445-2folsh35 33 2 values value NNS cord-007445-2folsh35 33 3 continued continue VBD cord-007445-2folsh35 33 4 to to TO cord-007445-2folsh35 33 5 be be VB cord-007445-2folsh35 33 6 lower low JJR cord-007445-2folsh35 33 7 at at IN cord-007445-2folsh35 33 8 age age NN cord-007445-2folsh35 33 9 6 6 CD cord-007445-2folsh35 33 10 and and CC cord-007445-2folsh35 33 11 by by IN cord-007445-2folsh35 33 12 age age NN cord-007445-2folsh35 33 13 11 11 CD cord-007445-2folsh35 33 14 , , , cord-007445-2folsh35 33 15 when when WRB cord-007445-2folsh35 33 16 forced force VBN cord-007445-2folsh35 33 17 expiratory expiratory JJ cord-007445-2folsh35 33 18 volume volume NN cord-007445-2folsh35 33 19 in in IN cord-007445-2folsh35 33 20 1 1 CD cord-007445-2folsh35 33 21 second second NN cord-007445-2folsh35 33 22 ( ( -LRB- cord-007445-2folsh35 33 23 FEVl FEVl NNS cord-007445-2folsh35 33 24 ) ) -RRB- cord-007445-2folsh35 33 25 and and CC cord-007445-2folsh35 33 26 FEF FEF NNP cord-007445-2folsh35 33 27 , , , cord-007445-2folsh35 33 28 , , , cord-007445-2folsh35 33 29 were be VBD cord-007445-2folsh35 33 30 recorded record VBN cord-007445-2folsh35 33 31 , , , cord-007445-2folsh35 33 32 similar similar JJ cord-007445-2folsh35 33 33 group group NN cord-007445-2folsh35 33 34 relationships relationship NNS cord-007445-2folsh35 33 35 persisted persist VBD cord-007445-2folsh35 33 36 . . . cord-007445-2folsh35 34 1 Interestingly interestingly RB cord-007445-2folsh35 34 2 , , , cord-007445-2folsh35 34 3 despite despite IN cord-007445-2folsh35 34 4 the the DT cord-007445-2folsh35 34 5 persistence persistence NN cord-007445-2folsh35 34 6 of of IN cord-007445-2folsh35 34 7 lowered lower VBN cord-007445-2folsh35 34 8 baseline baseline JJ cord-007445-2folsh35 34 9 lung lung NN cord-007445-2folsh35 34 10 function function NN cord-007445-2folsh35 34 11 in in IN cord-007445-2folsh35 34 12 both both CC cord-007445-2folsh35 34 13 the the DT cord-007445-2folsh35 34 14 pneumonia pneumonia NN cord-007445-2folsh35 34 15 and and CC cord-007445-2folsh35 34 16 LRI LRI NNP cord-007445-2folsh35 34 17 groups group NNS cord-007445-2folsh35 34 18 , , , cord-007445-2folsh35 34 19 many many JJ cord-007445-2folsh35 34 20 of of IN cord-007445-2folsh35 34 21 these these DT cord-007445-2folsh35 34 22 deficits deficit NNS cord-007445-2folsh35 34 23 were be VBD cord-007445-2folsh35 34 24 markedly markedly RB cord-007445-2folsh35 34 25 ( ( -LRB- cord-007445-2folsh35 34 26 but but CC cord-007445-2folsh35 34 27 not not RB cord-007445-2folsh35 34 28 completely completely RB cord-007445-2folsh35 34 29 ) ) -RRB- cord-007445-2folsh35 34 30 reduced reduce VBN cord-007445-2folsh35 34 31 following follow VBG cord-007445-2folsh35 34 32 administration administration NN cord-007445-2folsh35 34 33 of of IN cord-007445-2folsh35 34 34 albuterol albuterol NNP cord-007445-2folsh35 34 35 . . . cord-007445-2folsh35 35 1 In in IN cord-007445-2folsh35 35 2 a a DT cord-007445-2folsh35 35 3 second second JJ cord-007445-2folsh35 35 4 report report NN cord-007445-2folsh35 35 5 , , , cord-007445-2folsh35 35 6 further further RB cord-007445-2folsh35 35 7 follow follow NN cord-007445-2folsh35 35 8 - - HYPH cord-007445-2folsh35 35 9 up up NN cord-007445-2folsh35 35 10 of of IN cord-007445-2folsh35 35 11 this this DT cord-007445-2folsh35 35 12 large large JJ cord-007445-2folsh35 35 13 cohort cohort NN cord-007445-2folsh35 35 14 of of IN cord-007445-2folsh35 35 15 children child NNS cord-007445-2folsh35 35 16 demonstrated demonstrate VBD cord-007445-2folsh35 35 17 that that IN cord-007445-2folsh35 35 18 the the DT cord-007445-2folsh35 35 19 risk risk NN cord-007445-2folsh35 35 20 for for IN cord-007445-2folsh35 35 21 both both CC cord-007445-2folsh35 35 22 frequent frequent JJ cord-007445-2folsh35 35 23 ( ( -LRB- cord-007445-2folsh35 35 24 more more JJR cord-007445-2folsh35 35 25 than than IN cord-007445-2folsh35 35 26 three three CD cord-007445-2folsh35 35 27 episodes episode NNS cord-007445-2folsh35 35 28 of of IN cord-007445-2folsh35 35 29 wheezing wheezing NN cord-007445-2folsh35 35 30 per per IN cord-007445-2folsh35 35 31 year year NN cord-007445-2folsh35 35 32 ) ) -RRB- cord-007445-2folsh35 35 33 and and CC cord-007445-2folsh35 35 34 infrequent infrequent JJ cord-007445-2folsh35 35 35 ( ( -LRB- cord-007445-2folsh35 35 36 three three CD cord-007445-2folsh35 35 37 episodes episode NNS cord-007445-2folsh35 35 38 of of IN cord-007445-2folsh35 35 39 wheezing wheezing NN cord-007445-2folsh35 35 40 per per IN cord-007445-2folsh35 35 41 year year NN cord-007445-2folsh35 35 42 ) ) -RRB- cord-007445-2folsh35 35 43 wheezing wheeze VBG cord-007445-2folsh35 35 44 in in IN cord-007445-2folsh35 35 45 relation relation NN cord-007445-2folsh35 35 46 to to IN cord-007445-2folsh35 35 47 RSV RSV NNP cord-007445-2folsh35 35 48 lower low JJR cord-007445-2folsh35 35 49 respiratory respiratory JJ cord-007445-2folsh35 35 50 illnesses illness NNS cord-007445-2folsh35 35 51 decreased decrease VBD cord-007445-2folsh35 35 52 markedly markedly RB cord-007445-2folsh35 35 53 with with IN cord-007445-2folsh35 35 54 age age NN cord-007445-2folsh35 35 55 and and CC cord-007445-2folsh35 35 56 became become VBD cord-007445-2folsh35 35 57 nonsignificant nonsignificant JJ cord-007445-2folsh35 35 58 by by IN cord-007445-2folsh35 35 59 age age NN cord-007445-2folsh35 35 60 13.1 13.1 CD cord-007445-2folsh35 35 61 ° ° NN cord-007445-2folsh35 35 62 4 4 CD cord-007445-2folsh35 35 63 These these DT cord-007445-2folsh35 35 64 data datum NNS cord-007445-2folsh35 35 65 suggest suggest VBP cord-007445-2folsh35 35 66 that that IN cord-007445-2folsh35 35 67 , , , cord-007445-2folsh35 35 68 although although IN cord-007445-2folsh35 35 69 RSV RSV NNP cord-007445-2folsh35 35 70 infections infection NNS cord-007445-2folsh35 35 71 contribute contribute VBP cord-007445-2folsh35 35 72 substantially substantially RB cord-007445-2folsh35 35 73 to to IN cord-007445-2folsh35 35 74 the the DT cord-007445-2folsh35 35 75 expression expression NN cord-007445-2folsh35 35 76 of of IN cord-007445-2folsh35 35 77 the the DT cord-007445-2folsh35 35 78 asthmatic asthmatic JJ cord-007445-2folsh35 35 79 phenotype phenotype NN cord-007445-2folsh35 35 80 , , , cord-007445-2folsh35 35 81 other other JJ cord-007445-2folsh35 35 82 factors factor NNS cord-007445-2folsh35 35 83 ( ( -LRB- cord-007445-2folsh35 35 84 e.g. e.g. RB cord-007445-2folsh35 35 85 , , , cord-007445-2folsh35 35 86 genetic genetic JJ cord-007445-2folsh35 35 87 , , , cord-007445-2folsh35 35 88 environmental environmental JJ cord-007445-2folsh35 35 89 , , , cord-007445-2folsh35 35 90 developmental developmental JJ cord-007445-2folsh35 35 91 ) ) -RRB- cord-007445-2folsh35 35 92 ap ap NN cord-007445-2folsh35 35 93 - - HYPH cord-007445-2folsh35 35 94 pear pear NN cord-007445-2folsh35 35 95 to to TO cord-007445-2folsh35 35 96 contribute contribute VB cord-007445-2folsh35 35 97 as as RB cord-007445-2folsh35 35 98 well well RB cord-007445-2folsh35 35 99 , , , cord-007445-2folsh35 35 100 either either CC cord-007445-2folsh35 35 101 in in IN cord-007445-2folsh35 35 102 terms term NNS cord-007445-2folsh35 35 103 of of IN cord-007445-2folsh35 35 104 its -PRON- PRP$ cord-007445-2folsh35 35 105 initial initial JJ cord-007445-2folsh35 35 106 expression expression NN cord-007445-2folsh35 35 107 or or CC cord-007445-2folsh35 35 108 the the DT cord-007445-2folsh35 35 109 modification modification NN cord-007445-2folsh35 35 110 of of IN cord-007445-2folsh35 35 111 the the DT cord-007445-2folsh35 35 112 phenotype phenotype NN cord-007445-2folsh35 35 113 over over IN cord-007445-2folsh35 35 114 time time NN cord-007445-2folsh35 35 115 . . . cord-007445-2folsh35 36 1 In in IN cord-007445-2folsh35 36 2 addition addition NN cord-007445-2folsh35 36 3 to to IN cord-007445-2folsh35 36 4 premorbid premorbid NN cord-007445-2folsh35 36 5 lung lung NNP cord-007445-2folsh35 36 6 function function NN cord-007445-2folsh35 36 7 , , , cord-007445-2folsh35 36 8 the the DT cord-007445-2folsh35 36 9 influence influence NN cord-007445-2folsh35 36 10 of of IN cord-007445-2folsh35 36 11 atopy atopy NN cord-007445-2folsh35 36 12 on on IN cord-007445-2folsh35 36 13 the the DT cord-007445-2folsh35 36 14 development development NN cord-007445-2folsh35 36 15 of of IN cord-007445-2folsh35 36 16 the the DT cord-007445-2folsh35 36 17 asthmatic asthmatic JJ cord-007445-2folsh35 36 18 phenotype phenotype NN cord-007445-2folsh35 36 19 in in IN cord-007445-2folsh35 36 20 relationship relationship NN cord-007445-2folsh35 36 21 to to IN cord-007445-2folsh35 36 22 viral viral JJ cord-007445-2folsh35 36 23 infections infection NNS cord-007445-2folsh35 36 24 has have VBZ cord-007445-2folsh35 36 25 also also RB cord-007445-2folsh35 36 26 been be VBN cord-007445-2folsh35 36 27 evaluated evaluate VBN cord-007445-2folsh35 36 28 . . . cord-007445-2folsh35 37 1 Interactions interaction NNS cord-007445-2folsh35 37 2 between between IN cord-007445-2folsh35 37 3 these these DT cord-007445-2folsh35 37 4 two two CD cord-007445-2folsh35 37 5 factors factor NNS cord-007445-2folsh35 37 6 appear appear VBP cord-007445-2folsh35 37 7 to to TO cord-007445-2folsh35 37 8 be be VB cord-007445-2folsh35 37 9 bidirectional bidirectional JJ cord-007445-2folsh35 37 10 and and CC cord-007445-2folsh35 37 11 dynamic dynamic JJ cord-007445-2folsh35 37 12 , , , cord-007445-2folsh35 37 13 in in IN cord-007445-2folsh35 37 14 that that IN cord-007445-2folsh35 37 15 the the DT cord-007445-2folsh35 37 16 atopic atopic JJ cord-007445-2folsh35 37 17 state state NN cord-007445-2folsh35 37 18 can can MD cord-007445-2folsh35 37 19 influence influence VB cord-007445-2folsh35 37 20 the the DT cord-007445-2folsh35 37 21 lower low JJR cord-007445-2folsh35 37 22 airway airway NN cord-007445-2folsh35 37 23 response response NN cord-007445-2folsh35 37 24 to to IN cord-007445-2folsh35 37 25 viral viral JJ cord-007445-2folsh35 37 26 infections infection NNS cord-007445-2folsh35 37 27 ? ? . cord-007445-2folsh35 38 1 71 71 CD cord-007445-2folsh35 38 2 viral viral JJ cord-007445-2folsh35 38 3 infections infection NNS cord-007445-2folsh35 38 4 can can MD cord-007445-2folsh35 38 5 influence influence VB cord-007445-2folsh35 38 6 the the DT cord-007445-2folsh35 38 7 development development NN cord-007445-2folsh35 38 8 of of IN cord-007445-2folsh35 38 9 allergen allergen NN cord-007445-2folsh35 38 10 sensitization,28 sensitization,28 NNP cord-007445-2folsh35 38 11 , , , cord-007445-2folsh35 38 12 29 29 CD cord-007445-2folsh35 38 13 , , , cord-007445-2folsh35 38 14 99 99 CD cord-007445-2folsh35 38 15 and and CC cord-007445-2folsh35 38 16 interactions interaction NNS cord-007445-2folsh35 38 17 can can MD cord-007445-2folsh35 38 18 occur occur VB cord-007445-2folsh35 38 19 when when WRB cord-007445-2folsh35 38 20 individuals individual NNS cord-007445-2folsh35 38 21 are be VBP cord-007445-2folsh35 38 22 exposed expose VBN cord-007445-2folsh35 38 23 simultaneously simultaneously RB cord-007445-2folsh35 38 24 to to IN cord-007445-2folsh35 38 25 both both DT cord-007445-2folsh35 38 26 allergens allergen NNS cord-007445-2folsh35 38 27 and and CC cord-007445-2folsh35 38 28 viruses.1z viruses.1z NN cord-007445-2folsh35 38 29 , , , cord-007445-2folsh35 38 30 68 68 CD cord-007445-2folsh35 38 31 , , , cord-007445-2folsh35 38 32 Atopy Atopy NNP cord-007445-2folsh35 38 33 can can MD cord-007445-2folsh35 38 34 be be VB cord-007445-2folsh35 38 35 defined define VBN cord-007445-2folsh35 38 36 as as IN cord-007445-2folsh35 38 37 the the DT cord-007445-2folsh35 38 38 genetic genetic JJ cord-007445-2folsh35 38 39 predisposition predisposition NN cord-007445-2folsh35 38 40 to to IN cord-007445-2folsh35 38 41 the the DT cord-007445-2folsh35 38 42 preferential preferential JJ cord-007445-2folsh35 38 43 development development NN cord-007445-2folsh35 38 44 of of IN cord-007445-2folsh35 38 45 an an DT cord-007445-2folsh35 38 46 immunoglobulin immunoglobulin NN cord-007445-2folsh35 38 47 ( ( -LRB- cord-007445-2folsh35 38 48 1g)E 1g)e CD cord-007445-2folsh35 38 49 antibody antibody NN cord-007445-2folsh35 38 50 response response NN cord-007445-2folsh35 38 51 to to IN cord-007445-2folsh35 38 52 a a DT cord-007445-2folsh35 38 53 variety variety NN cord-007445-2folsh35 38 54 of of IN cord-007445-2folsh35 38 55 environmental environmental JJ cord-007445-2folsh35 38 56 allergens allergen NNS cord-007445-2folsh35 38 57 . . . cord-007445-2folsh35 39 1 As as IN cord-007445-2folsh35 39 2 stated state VBN cord-007445-2folsh35 39 3 previously previously RB cord-007445-2folsh35 39 4 , , , cord-007445-2folsh35 39 5 atopy atopy NN cord-007445-2folsh35 39 6 has have VBZ cord-007445-2folsh35 39 7 been be VBN cord-007445-2folsh35 39 8 considered consider VBN cord-007445-2folsh35 39 9 to to TO cord-007445-2folsh35 39 10 be be VB cord-007445-2folsh35 39 11 a a DT cord-007445-2folsh35 39 12 risk risk NN cord-007445-2folsh35 39 13 factor factor NN cord-007445-2folsh35 39 14 for for IN cord-007445-2folsh35 39 15 the the DT cord-007445-2folsh35 39 16 development development NN cord-007445-2folsh35 39 17 of of IN cord-007445-2folsh35 39 18 childhood childhood NN cord-007445-2folsh35 39 19 asthma asthma NN cord-007445-2folsh35 39 20 and and CC cord-007445-2folsh35 39 21 its -PRON- PRP$ cord-007445-2folsh35 39 22 influence influence NN cord-007445-2folsh35 39 23 on on IN cord-007445-2folsh35 39 24 the the DT cord-007445-2folsh35 39 25 pattern pattern NN cord-007445-2folsh35 39 26 of of IN cord-007445-2folsh35 39 27 responses response NNS cord-007445-2folsh35 39 28 following follow VBG cord-007445-2folsh35 39 29 viral viral JJ cord-007445-2folsh35 39 30 infections infection NNS cord-007445-2folsh35 39 31 has have VBZ cord-007445-2folsh35 39 32 been be VBN cord-007445-2folsh35 39 33 of of IN cord-007445-2folsh35 39 34 interest interest NN cord-007445-2folsh35 39 35 to to IN cord-007445-2folsh35 39 36 many many JJ cord-007445-2folsh35 39 37 investigative investigative JJ cord-007445-2folsh35 39 38 groups group NNS cord-007445-2folsh35 39 39 . . . cord-007445-2folsh35 40 1 It -PRON- PRP cord-007445-2folsh35 40 2 has have VBZ cord-007445-2folsh35 40 3 also also RB cord-007445-2folsh35 40 4 been be VBN cord-007445-2folsh35 40 5 suggested suggest VBN cord-007445-2folsh35 40 6 that that IN cord-007445-2folsh35 40 7 atopy atopy NN cord-007445-2folsh35 40 8 could could MD cord-007445-2folsh35 40 9 be be VB cord-007445-2folsh35 40 10 a a DT cord-007445-2folsh35 40 11 significant significant JJ cord-007445-2folsh35 40 12 predisposing predisposing NN cord-007445-2folsh35 40 13 factor factor NN cord-007445-2folsh35 40 14 for for IN cord-007445-2folsh35 40 15 the the DT cord-007445-2folsh35 40 16 development development NN cord-007445-2folsh35 40 17 of of IN cord-007445-2folsh35 40 18 acute acute JJ cord-007445-2folsh35 40 19 bronchiolitis bronchiolitis NN cord-007445-2folsh35 40 20 during during IN cord-007445-2folsh35 40 21 RSV RSV NNP cord-007445-2folsh35 40 22 epid epid NNP cord-007445-2folsh35 40 23 e e NNP cord-007445-2folsh35 40 24 m m NN cord-007445-2folsh35 41 1 i i PRP cord-007445-2folsh35 41 2 c~.~~ c~.~~ NNPS cord-007445-2folsh35 42 1 Although although IN cord-007445-2folsh35 42 2 some some DT cord-007445-2folsh35 42 3 have have VBP cord-007445-2folsh35 42 4 found find VBN cord-007445-2folsh35 42 5 that that IN cord-007445-2folsh35 42 6 children child NNS cord-007445-2folsh35 42 7 most most RBS cord-007445-2folsh35 42 8 likely likely JJ cord-007445-2folsh35 42 9 to to TO cord-007445-2folsh35 42 10 have have VB cord-007445-2folsh35 42 11 persistent persistent JJ cord-007445-2folsh35 42 12 wheezing wheeze VBG cord-007445-2folsh35 42 13 were be VBD cord-007445-2folsh35 42 14 those those DT cord-007445-2folsh35 42 15 born bear VBN cord-007445-2folsh35 42 16 to to IN cord-007445-2folsh35 42 17 atopic atopic NNP cord-007445-2folsh35 42 18 parents,64 parents,64 NNP cord-007445-2folsh35 42 19 , , , cord-007445-2folsh35 42 20 91 91 CD cord-007445-2folsh35 42 21 , , , cord-007445-2folsh35 42 22 lZ1 lz1 WDT cord-007445-2folsh35 42 23 others other NNS cord-007445-2folsh35 42 24 have have VBP cord-007445-2folsh35 42 25 not.14 not.14 NNP cord-007445-2folsh35 42 26 , , , cord-007445-2folsh35 42 27 73 73 CD cord-007445-2folsh35 42 28 , , , cord-007445-2folsh35 42 29 84 84 CD cord-007445-2folsh35 43 1 Some some DT cord-007445-2folsh35 43 2 have have VBP cord-007445-2folsh35 43 3 found find VBN cord-007445-2folsh35 43 4 that that IN cord-007445-2folsh35 43 5 personal personal JJ cord-007445-2folsh35 43 6 atopy atopy NN cord-007445-2folsh35 43 7 is be VBZ cord-007445-2folsh35 43 8 not not RB cord-007445-2folsh35 43 9 more more RBR cord-007445-2folsh35 43 10 prevalent prevalent JJ cord-007445-2folsh35 43 11 in in IN cord-007445-2folsh35 43 12 symptomatic symptomatic JJ cord-007445-2folsh35 43 13 children child NNS cord-007445-2folsh35 43 14 after after IN cord-007445-2folsh35 43 15 br br NNP cord-007445-2folsh35 43 16 ~ ~ NFP cord-007445-2folsh35 43 17 nchiolitis'~ nchiolitis'~ ADD cord-007445-2folsh35 43 18 , , , cord-007445-2folsh35 43 19 73 73 CD cord-007445-2folsh35 43 20 ; ; : cord-007445-2folsh35 43 21 others other NNS cord-007445-2folsh35 43 22 have have VBP cord-007445-2folsh35 43 23 found find VBN cord-007445-2folsh35 43 24 that that IN cord-007445-2folsh35 43 25 documented document VBN cord-007445-2folsh35 43 26 RSV RSV NNP cord-007445-2folsh35 43 27 bronchiolitis bronchiolitis NN cord-007445-2folsh35 43 28 significantly significantly RB cord-007445-2folsh35 43 29 increases increase VBZ cord-007445-2folsh35 43 30 a a DT cord-007445-2folsh35 43 31 child child NN cord-007445-2folsh35 43 32 's 's POS cord-007445-2folsh35 43 33 chances chance NNS cord-007445-2folsh35 43 34 ( ( -LRB- cord-007445-2folsh35 43 35 32 32 CD cord-007445-2folsh35 43 36 % % NN cord-007445-2folsh35 43 37 versus versus IN cord-007445-2folsh35 43 38 9 9 CD cord-007445-2folsh35 43 39 % % NN cord-007445-2folsh35 43 40 in in IN cord-007445-2folsh35 43 41 controls control NNS cord-007445-2folsh35 43 42 ) ) -RRB- cord-007445-2folsh35 43 43 of of IN cord-007445-2folsh35 43 44 subsequently subsequently RB cord-007445-2folsh35 43 45 developing develop VBG cord-007445-2folsh35 43 46 IgE IgE NNP cord-007445-2folsh35 43 47 antibody% antibody% NNP cord-007445-2folsh35 43 48 or or CC cord-007445-2folsh35 43 49 lymphocyte lymphocyte NN cord-007445-2folsh35 43 50 proliferative proliferative FW cord-007445-2folsh35 43 51 responses75 responses75 XX cord-007445-2folsh35 43 52 to to IN cord-007445-2folsh35 43 53 both both CC cord-007445-2folsh35 43 54 food food NN cord-007445-2folsh35 43 55 and and CC cord-007445-2folsh35 43 56 aeroallergens aeroallergen NNS cord-007445-2folsh35 43 57 . . . cord-007445-2folsh35 44 1 Respiratory respiratory JJ cord-007445-2folsh35 44 2 syncytial syncytial JJ cord-007445-2folsh35 44 3 virus virus NN cord-007445-2folsh35 44 4 infections infection NNS cord-007445-2folsh35 44 5 may may MD cord-007445-2folsh35 44 6 interact interact VB cord-007445-2folsh35 44 7 with with IN cord-007445-2folsh35 44 8 immunoinflammatory immunoinflammatory NN cord-007445-2folsh35 44 9 mechanisms mechanism NNS cord-007445-2folsh35 44 10 involved involve VBN cord-007445-2folsh35 44 11 in in IN cord-007445-2folsh35 44 12 immediate immediate JJ cord-007445-2folsh35 44 13 hypersensitivity hypersensitivity NN cord-007445-2folsh35 44 14 responses response NNS cord-007445-2folsh35 44 15 in in IN cord-007445-2folsh35 44 16 a a DT cord-007445-2folsh35 44 17 number number NN cord-007445-2folsh35 44 18 of of IN cord-007445-2folsh35 45 1 ways.18 ways.18 NNP cord-007445-2folsh35 45 2 First First NNP cord-007445-2folsh35 45 3 , , , cord-007445-2folsh35 45 4 it -PRON- PRP cord-007445-2folsh35 45 5 has have VBZ cord-007445-2folsh35 45 6 been be VBN cord-007445-2folsh35 45 7 suggested suggest VBN cord-007445-2folsh35 45 8 that that IN cord-007445-2folsh35 45 9 viruses virus NNS cord-007445-2folsh35 45 10 capable capable JJ cord-007445-2folsh35 45 11 of of IN cord-007445-2folsh35 45 12 infecting infect VBG cord-007445-2folsh35 45 13 lower low JJR cord-007445-2folsh35 45 14 airway airway NN cord-007445-2folsh35 45 15 epithelium epithelium NN cord-007445-2folsh35 45 16 may may MD cord-007445-2folsh35 45 17 lead lead VB cord-007445-2folsh35 45 18 to to IN cord-007445-2folsh35 45 19 enhanced enhance VBN cord-007445-2folsh35 45 20 absorption absorption NN cord-007445-2folsh35 45 21 of of IN cord-007445-2folsh35 45 22 aeroallergens aeroallergen NNS cord-007445-2folsh35 45 23 across across IN cord-007445-2folsh35 45 24 the the DT cord-007445-2folsh35 45 25 airway airway NN cord-007445-2folsh35 45 26 wall wall NN cord-007445-2folsh35 45 27 , , , cord-007445-2folsh35 45 28 predisposing predispose VBG cord-007445-2folsh35 45 29 to to IN cord-007445-2folsh35 45 30 subsequent subsequent JJ cord-007445-2folsh35 45 31 sensitizati sensitizati NN cord-007445-2folsh35 45 32 ~ ~ CD cord-007445-2folsh35 45 33 n.~~ n.~~ NN cord-007445-2folsh35 46 1 , , , cord-007445-2folsh35 46 2 94 94 CD cord-007445-2folsh35 46 3 Second Second NNP cord-007445-2folsh35 46 4 , , , cord-007445-2folsh35 46 5 RSV RSV NNP cord-007445-2folsh35 46 6 - - HYPH cord-007445-2folsh35 46 7 specific specific JJ cord-007445-2folsh35 46 8 IgE IgE NNP cord-007445-2folsh35 46 9 antibody antibody NN cord-007445-2folsh35 46 10 formation formation NN cord-007445-2folsh35 46 11 may may MD cord-007445-2folsh35 46 12 lead lead VB cord-007445-2folsh35 46 13 to to IN cord-007445-2folsh35 46 14 mast mast JJ cord-007445-2folsh35 46 15 - - HYPH cord-007445-2folsh35 46 16 cellmediator cellmediator NN cord-007445-2folsh35 46 17 release release NN cord-007445-2folsh35 46 18 within within IN cord-007445-2folsh35 46 19 the the DT cord-007445-2folsh35 46 20 airway airway NN cord-007445-2folsh35 46 21 , , , cord-007445-2folsh35 46 22 resulting result VBG cord-007445-2folsh35 46 23 in in IN cord-007445-2folsh35 46 24 the the DT cord-007445-2folsh35 46 25 development development NN cord-007445-2folsh35 46 26 of of IN cord-007445-2folsh35 46 27 bronchospasm bronchospasm NN cord-007445-2folsh35 46 28 and and CC cord-007445-2folsh35 46 29 the the DT cord-007445-2folsh35 46 30 ingress ingress NN cord-007445-2folsh35 46 31 of of IN cord-007445-2folsh35 46 32 eo eo NNP cord-007445-2folsh35 46 33 ~ ~ NNP cord-007445-2folsh35 46 34 inophils.~~ inophils.~~ NNP cord-007445-2folsh35 46 35 , , , cord-007445-2folsh35 47 1 60 60 CD cord-007445-2folsh35 47 2 , , , cord-007445-2folsh35 47 3 85 85 CD cord-007445-2folsh35 47 4 , , , cord-007445-2folsh35 47 5 115 115 CD cord-007445-2folsh35 47 6 Respiratory respiratory JJ cord-007445-2folsh35 47 7 syncytial syncytial JJ cord-007445-2folsh35 47 8 virus virus NN cord-007445-2folsh35 47 9 belongs belong VBZ cord-007445-2folsh35 47 10 to to IN cord-007445-2folsh35 47 11 the the DT cord-007445-2folsh35 47 12 family family NN cord-007445-2folsh35 47 13 Paramyxoviridae Paramyxoviridae NNP cord-007445-2folsh35 47 14 , , , cord-007445-2folsh35 47 15 the the DT cord-007445-2folsh35 47 16 genera genera NNP cord-007445-2folsh35 47 17 Pneumovirus Pneumovirus NNP cord-007445-2folsh35 47 18 , , , cord-007445-2folsh35 47 19 and and CC cord-007445-2folsh35 47 20 can can MD cord-007445-2folsh35 47 21 be be VB cord-007445-2folsh35 47 22 differentiated differentiate VBN cord-007445-2folsh35 47 23 into into IN cord-007445-2folsh35 47 24 two two CD cord-007445-2folsh35 47 25 serologic serologic JJ cord-007445-2folsh35 47 26 subgroups subgroup NNS cord-007445-2folsh35 47 27 , , , cord-007445-2folsh35 47 28 A A NNP cord-007445-2folsh35 47 29 and and CC cord-007445-2folsh35 47 30 B.M B.M NNP cord-007445-2folsh35 47 31 , , , cord-007445-2folsh35 47 32 It -PRON- PRP cord-007445-2folsh35 47 33 has have VBZ cord-007445-2folsh35 47 34 10 10 CD cord-007445-2folsh35 47 35 genes gene NNS cord-007445-2folsh35 47 36 , , , cord-007445-2folsh35 47 37 with with IN cord-007445-2folsh35 47 38 12 12 CD cord-007445-2folsh35 47 39 potential potential JJ cord-007445-2folsh35 47 40 gene gene NN cord-007445-2folsh35 47 41 products product NNS cord-007445-2folsh35 47 42 . . . cord-007445-2folsh35 48 1 The the DT cord-007445-2folsh35 48 2 G g NN cord-007445-2folsh35 48 3 ( ( -LRB- cord-007445-2folsh35 48 4 attachment attachment NN cord-007445-2folsh35 48 5 ) ) -RRB- cord-007445-2folsh35 48 6 and and CC cord-007445-2folsh35 48 7 F F NNP cord-007445-2folsh35 48 8 ( ( -LRB- cord-007445-2folsh35 48 9 fusion fusion NN cord-007445-2folsh35 48 10 ) ) -RRB- cord-007445-2folsh35 48 11 proteins protein NNS cord-007445-2folsh35 48 12 are be VBP cord-007445-2folsh35 48 13 the the DT cord-007445-2folsh35 48 14 major major JJ cord-007445-2folsh35 48 15 su$ace su$ace NN cord-007445-2folsh35 48 16 glycoproteins glycoprotein NNS cord-007445-2folsh35 48 17 against against IN cord-007445-2folsh35 48 18 which which WDT cord-007445-2folsh35 48 19 neutralizing neutralize VBG cord-007445-2folsh35 48 20 antibody antibody NN cord-007445-2folsh35 48 21 is be VBZ cord-007445-2folsh35 48 22 directed direct VBN cord-007445-2folsh35 48 23 . . . cord-007445-2folsh35 49 1 Interestingly interestingly RB cord-007445-2folsh35 49 2 , , , cord-007445-2folsh35 49 3 in in IN cord-007445-2folsh35 49 4 both both CC cord-007445-2folsh35 49 5 murine2 murine2 NN cord-007445-2folsh35 49 6 and and CC cord-007445-2folsh35 49 7 hurnan5l hurnan5l NNP cord-007445-2folsh35 49 8 in in IN cord-007445-2folsh35 49 9 vitro vitro FW cord-007445-2folsh35 49 10 experiments experiment NNS cord-007445-2folsh35 49 11 , , , cord-007445-2folsh35 49 12 it -PRON- PRP cord-007445-2folsh35 49 13 has have VBZ cord-007445-2folsh35 49 14 been be VBN cord-007445-2folsh35 49 15 noted note VBN cord-007445-2folsh35 49 16 that that IN cord-007445-2folsh35 49 17 the the DT cord-007445-2folsh35 49 18 G G NNP cord-007445-2folsh35 49 19 protein protein NN cord-007445-2folsh35 49 20 elicits elicit VBZ cord-007445-2folsh35 49 21 a a DT cord-007445-2folsh35 49 22 predominant predominant JJ cord-007445-2folsh35 49 23 Th2 th2 CD cord-007445-2folsh35 49 24 response response NN cord-007445-2folsh35 49 25 , , , cord-007445-2folsh35 49 26 whereas whereas IN cord-007445-2folsh35 49 27 the the DT cord-007445-2folsh35 49 28 F F NNP cord-007445-2folsh35 49 29 protein protein NN cord-007445-2folsh35 49 30 produces produce VBZ cord-007445-2folsh35 49 31 a a DT cord-007445-2folsh35 49 32 predominant predominant JJ cord-007445-2folsh35 49 33 Thl Thl NNP cord-007445-2folsh35 49 34 response response NN cord-007445-2folsh35 49 35 . . . cord-007445-2folsh35 50 1 In in IN cord-007445-2folsh35 50 2 mice mouse NNS cord-007445-2folsh35 50 3 , , , cord-007445-2folsh35 50 4 to to TO cord-007445-2folsh35 50 5 test test VB cord-007445-2folsh35 50 6 the the DT cord-007445-2folsh35 50 7 activities activity NNS cord-007445-2folsh35 50 8 of of IN cord-007445-2folsh35 50 9 T t NN cord-007445-2folsh35 50 10 cells cell NNS cord-007445-2folsh35 50 11 recognizing recognize VBG cord-007445-2folsh35 50 12 individual individual JJ cord-007445-2folsh35 50 13 RSV RSV NNP cord-007445-2folsh35 50 14 proteins protein NNS cord-007445-2folsh35 50 15 in in IN cord-007445-2folsh35 50 16 vivo vivo NN cord-007445-2folsh35 50 17 , , , cord-007445-2folsh35 50 18 virus virus NN cord-007445-2folsh35 50 19 - - HYPH cord-007445-2folsh35 50 20 specific specific JJ cord-007445-2folsh35 50 21 T t NN cord-007445-2folsh35 50 22 - - HYPH cord-007445-2folsh35 50 23 cell cell NN cord-007445-2folsh35 50 24 lines line NNS cord-007445-2folsh35 50 25 have have VBP cord-007445-2folsh35 50 26 been be VBN cord-007445-2folsh35 50 27 produced produce VBN cord-007445-2folsh35 50 28 using use VBG cord-007445-2folsh35 50 29 recombinant recombinant JJ cord-007445-2folsh35 50 30 vaccinia vaccinia NN cord-007445-2folsh35 50 31 viruses virus NNS cord-007445-2folsh35 50 32 that that WDT cord-007445-2folsh35 50 33 express express VBP cord-007445-2folsh35 50 34 either either CC cord-007445-2folsh35 50 35 the the DT cord-007445-2folsh35 50 36 G G NNP cord-007445-2folsh35 50 37 or or CC cord-007445-2folsh35 50 38 F f NN cord-007445-2folsh35 50 39 proteins protein NNS cord-007445-2folsh35 50 40 . . . cord-007445-2folsh35 51 1 Following follow VBG cord-007445-2folsh35 51 2 passive passive JJ cord-007445-2folsh35 51 3 transfer transfer NN cord-007445-2folsh35 51 4 of of IN cord-007445-2folsh35 51 5 these these DT cord-007445-2folsh35 51 6 cell cell NN cord-007445-2folsh35 51 7 lines line NNS cord-007445-2folsh35 51 8 to to IN cord-007445-2folsh35 51 9 naive naive JJ cord-007445-2folsh35 51 10 recipients recipient NNS cord-007445-2folsh35 51 11 and and CC cord-007445-2folsh35 51 12 subsequent subsequent JJ cord-007445-2folsh35 51 13 intranasal intranasal NN cord-007445-2folsh35 51 14 inoculation inoculation NN cord-007445-2folsh35 51 15 with with IN cord-007445-2folsh35 51 16 RSV RSV NNP cord-007445-2folsh35 51 17 mice mouse NNS cord-007445-2folsh35 51 18 receiving receive VBG cord-007445-2folsh35 51 19 G g NN cord-007445-2folsh35 51 20 - - HYPH cord-007445-2folsh35 51 21 specific specific JJ cord-007445-2folsh35 51 22 cells cell NNS cord-007445-2folsh35 51 23 have have VBP cord-007445-2folsh35 51 24 more more JJR cord-007445-2folsh35 51 25 severe severe JJ cord-007445-2folsh35 51 26 illnesses illness NNS cord-007445-2folsh35 51 27 , , , cord-007445-2folsh35 51 28 characterized characterize VBN cord-007445-2folsh35 51 29 by by IN cord-007445-2folsh35 51 30 lung lung NN cord-007445-2folsh35 51 31 hemorrhage hemorrhage NN cord-007445-2folsh35 51 32 , , , cord-007445-2folsh35 51 33 pulmonary pulmonary JJ cord-007445-2folsh35 51 34 neutrophil neutrophil NN cord-007445-2folsh35 51 35 recruitment recruitment NN cord-007445-2folsh35 51 36 , , , cord-007445-2folsh35 51 37 and and CC cord-007445-2folsh35 51 38 intense intense JJ cord-007445-2folsh35 51 39 pulmonary pulmonary JJ cord-007445-2folsh35 51 40 eosinophi1ia.l eosinophi1ia.l NN cord-007445-2folsh35 52 1 These these DT cord-007445-2folsh35 52 2 experiments experiment NNS cord-007445-2folsh35 52 3 are be VBP cord-007445-2folsh35 52 4 of of IN cord-007445-2folsh35 52 5 interest interest NN cord-007445-2folsh35 52 6 based base VBN cord-007445-2folsh35 52 7 on on IN cord-007445-2folsh35 52 8 the the DT cord-007445-2folsh35 52 9 adverse adverse JJ cord-007445-2folsh35 52 10 clinical clinical JJ cord-007445-2folsh35 52 11 response response NN cord-007445-2folsh35 52 12 noted note VBN cord-007445-2folsh35 52 13 in in IN cord-007445-2folsh35 52 14 many many JJ cord-007445-2folsh35 52 15 infants infant NNS cord-007445-2folsh35 52 16 who who WP cord-007445-2folsh35 52 17 received receive VBD cord-007445-2folsh35 52 18 a a DT cord-007445-2folsh35 52 19 formalin formalin NN cord-007445-2folsh35 52 20 - - HYPH cord-007445-2folsh35 52 21 inactivated inactivate VBN cord-007445-2folsh35 52 22 RSV RSV NNP cord-007445-2folsh35 52 23 vaccine vaccine NN cord-007445-2folsh35 52 24 and and CC cord-007445-2folsh35 52 25 subsequently subsequently RB cord-007445-2folsh35 52 26 became become VBD cord-007445-2folsh35 52 27 infected infect VBN cord-007445-2folsh35 52 28 with with IN cord-007445-2folsh35 52 29 RSV RSV NNP cord-007445-2folsh35 52 30 ? ? . cord-007445-2folsh35 53 1 These these DT cord-007445-2folsh35 53 2 intriguing intriguing JJ cord-007445-2folsh35 53 3 observations observation NNS cord-007445-2folsh35 53 4 regarding regard VBG cord-007445-2folsh35 53 5 RSV RSV NNP cord-007445-2folsh35 53 6 and and CC cord-007445-2folsh35 53 7 its -PRON- PRP$ cord-007445-2folsh35 53 8 influence influence NN cord-007445-2folsh35 53 9 on on IN cord-007445-2folsh35 53 10 Thl Thl NNP cord-007445-2folsh35 53 11 /Th2 /Th2 . cord-007445-2folsh35 54 1 responses response NNS cord-007445-2folsh35 54 2 have have VBP cord-007445-2folsh35 54 3 recently recently RB cord-007445-2folsh35 54 4 been be VBN cord-007445-2folsh35 54 5 expanded expand VBN cord-007445-2folsh35 54 6 . . . cord-007445-2folsh35 55 1 Roman Roman NNP cord-007445-2folsh35 55 2 et et NNP cord-007445-2folsh35 55 3 a1 a1 NNP cord-007445-2folsh35 55 4 evaluated evaluate VBD cord-007445-2folsh35 55 5 15 15 CD cord-007445-2folsh35 55 6 hospitalized hospitalize VBN cord-007445-2folsh35 55 7 infants infant NNS cord-007445-2folsh35 55 8 ( ( -LRB- cord-007445-2folsh35 55 9 1 1 CD cord-007445-2folsh35 55 10 - - SYM cord-007445-2folsh35 55 11 15 15 CD cord-007445-2folsh35 55 12 months month NNS cord-007445-2folsh35 55 13 ) ) -RRB- cord-007445-2folsh35 55 14 with with IN cord-007445-2folsh35 55 15 an an DT cord-007445-2folsh35 55 16 acute acute JJ cord-007445-2folsh35 55 17 lower low JJR cord-007445-2folsh35 55 18 respiratory respiratory JJ cord-007445-2folsh35 55 19 tract tract NN cord-007445-2folsh35 55 20 infection infection NN cord-007445-2folsh35 55 21 caused cause VBN cord-007445-2folsh35 55 22 by by IN cord-007445-2folsh35 55 23 RSV RSV NNP cord-007445-2folsh35 55 24 . . . cord-007445-2folsh35 56 1 Compared compare VBN cord-007445-2folsh35 56 2 with with IN cord-007445-2folsh35 56 3 control control NN cord-007445-2folsh35 56 4 infants infant NNS cord-007445-2folsh35 56 5 , , , cord-007445-2folsh35 56 6 peripheral peripheral JJ cord-007445-2folsh35 56 7 blood blood NN cord-007445-2folsh35 56 8 cells cell NNS cord-007445-2folsh35 56 9 from from IN cord-007445-2folsh35 56 10 infected infected JJ cord-007445-2folsh35 56 11 children child NNS cord-007445-2folsh35 56 12 had have VBD cord-007445-2folsh35 56 13 suppressed suppress VBN cord-007445-2folsh35 56 14 IFN-?/ ifn-?/ JJ cord-007445-2folsh35 56 15 production production NN cord-007445-2folsh35 56 16 ex ex NN cord-007445-2folsh35 56 17 vivo vivo NN cord-007445-2folsh35 56 18 and and CC cord-007445-2folsh35 56 19 , , , cord-007445-2folsh35 56 20 although although IN cord-007445-2folsh35 56 21 IL-4 IL-4 NNP cord-007445-2folsh35 56 22 production production NN cord-007445-2folsh35 56 23 was be VBD cord-007445-2folsh35 56 24 also also RB cord-007445-2folsh35 56 25 decreased decrease VBN cord-007445-2folsh35 56 26 , , , cord-007445-2folsh35 56 27 the the DT cord-007445-2folsh35 56 28 IL-4/ IL-4/ NNP cord-007445-2folsh35 56 29 IFN IFN NNP cord-007445-2folsh35 56 30 - - HYPH cord-007445-2folsh35 56 31 y y NNP cord-007445-2folsh35 56 32 ratio ratio NN cord-007445-2folsh35 56 33 was be VBD cord-007445-2folsh35 56 34 significantly significantly RB cord-007445-2folsh35 56 35 increased increase VBN cord-007445-2folsh35 56 36 . . . cord-007445-2folsh35 57 1 Renzi Renzi NNP cord-007445-2folsh35 57 2 et et NNP cord-007445-2folsh35 58 1 a a DT cord-007445-2folsh35 58 2 P p NN cord-007445-2folsh35 58 3 prospectively prospectively RB cord-007445-2folsh35 58 4 followed follow VBD cord-007445-2folsh35 58 5 26 26 CD cord-007445-2folsh35 58 6 infants infant NNS cord-007445-2folsh35 58 7 hospitalized hospitalize VBN cord-007445-2folsh35 58 8 with with IN cord-007445-2folsh35 58 9 bronchiolitis bronchiolitis NN cord-007445-2folsh35 58 10 by by IN cord-007445-2folsh35 58 11 obtaining obtain VBG cord-007445-2folsh35 58 12 blood blood NN cord-007445-2folsh35 58 13 samples sample NNS cord-007445-2folsh35 58 14 at at IN cord-007445-2folsh35 58 15 the the DT cord-007445-2folsh35 58 16 time time NN cord-007445-2folsh35 58 17 of of IN cord-007445-2folsh35 58 18 illness illness NN cord-007445-2folsh35 58 19 and and CC cord-007445-2folsh35 58 20 5 5 CD cord-007445-2folsh35 58 21 months month NNS cord-007445-2folsh35 58 22 later later RB cord-007445-2folsh35 58 23 , , , cord-007445-2folsh35 58 24 and and CC cord-007445-2folsh35 58 25 found find VBD cord-007445-2folsh35 58 26 that that IN cord-007445-2folsh35 58 27 immune immune JJ cord-007445-2folsh35 58 28 responses response NNS cord-007445-2folsh35 58 29 during during IN cord-007445-2folsh35 58 30 the the DT cord-007445-2folsh35 58 31 acute acute JJ cord-007445-2folsh35 58 32 infection infection NN cord-007445-2folsh35 58 33 correlated correlate VBN cord-007445-2folsh35 58 34 with with IN cord-007445-2folsh35 58 35 long long JJ cord-007445-2folsh35 58 36 - - HYPH cord-007445-2folsh35 58 37 term term NN cord-007445-2folsh35 58 38 pulmonary pulmonary JJ cord-007445-2folsh35 58 39 outcomes outcome NNS cord-007445-2folsh35 58 40 . . . cord-007445-2folsh35 59 1 Blood blood NN cord-007445-2folsh35 59 2 lymphocytes lymphocyte NNS cord-007445-2folsh35 59 3 , , , cord-007445-2folsh35 59 4 obtained obtain VBN cord-007445-2folsh35 59 5 during during IN cord-007445-2folsh35 59 6 the the DT cord-007445-2folsh35 59 7 time time NN cord-007445-2folsh35 59 8 of of IN cord-007445-2folsh35 59 9 bronchiolitis bronchiolitis NN cord-007445-2folsh35 59 10 , , , cord-007445-2folsh35 59 11 produced produce VBD cord-007445-2folsh35 59 12 less less RBR cord-007445-2folsh35 59 13 IFN-?/ ifn-?/ JJ cord-007445-2folsh35 59 14 ex ex NN cord-007445-2folsh35 59 15 vivo vivo NN cord-007445-2folsh35 59 16 in in IN cord-007445-2folsh35 59 17 response response NN cord-007445-2folsh35 59 18 to to IN cord-007445-2folsh35 59 19 IL-2 IL-2 NNP cord-007445-2folsh35 59 20 and and CC cord-007445-2folsh35 59 21 more more JJR cord-007445-2folsh35 59 22 IL-4 IL-4 NNP cord-007445-2folsh35 59 23 in in IN cord-007445-2folsh35 59 24 response response NN cord-007445-2folsh35 59 25 to to IN cord-007445-2folsh35 59 26 D. D. NNP cord-007445-2folsh35 59 27 furinue furinue NNP cord-007445-2folsh35 59 28 antigen antigen NN cord-007445-2folsh35 59 29 in in IN cord-007445-2folsh35 59 30 children child NNS cord-007445-2folsh35 59 31 who who WP cord-007445-2folsh35 59 32 went go VBD cord-007445-2folsh35 59 33 on on RP cord-007445-2folsh35 59 34 to to TO cord-007445-2folsh35 59 35 develop develop VB cord-007445-2folsh35 59 36 a a DT cord-007445-2folsh35 59 37 pattern pattern NN cord-007445-2folsh35 59 38 of of IN cord-007445-2folsh35 59 39 recurrent recurrent JJ cord-007445-2folsh35 59 40 wheezing.8s wheezing.8s NN cord-007445-2folsh35 59 41 Finally finally RB cord-007445-2folsh35 59 42 , , , cord-007445-2folsh35 60 1 lower low JJR cord-007445-2folsh35 60 2 IFN IFN NNP cord-007445-2folsh35 60 3 - - HYPH cord-007445-2folsh35 60 4 y y NNP cord-007445-2folsh35 60 5 production production NN cord-007445-2folsh35 60 6 at at IN cord-007445-2folsh35 60 7 the the DT cord-007445-2folsh35 60 8 time time NN cord-007445-2folsh35 60 9 of of IN cord-007445-2folsh35 60 10 bronchiolitis bronchiolitis NN cord-007445-2folsh35 60 11 has have VBZ cord-007445-2folsh35 60 12 been be VBN cord-007445-2folsh35 60 13 demonstrated demonstrate VBN cord-007445-2folsh35 60 14 to to TO cord-007445-2folsh35 60 15 be be VB cord-007445-2folsh35 60 16 an an DT cord-007445-2folsh35 60 17 indicator indicator NN cord-007445-2folsh35 60 18 of of IN cord-007445-2folsh35 60 19 reduced reduce VBN cord-007445-2folsh35 60 20 pulmonary pulmonary JJ cord-007445-2folsh35 60 21 function function NN cord-007445-2folsh35 60 22 and and CC cord-007445-2folsh35 60 23 increased increase VBN cord-007445-2folsh35 60 24 responsiveness responsiveness NN cord-007445-2folsh35 60 25 to to IN cord-007445-2folsh35 60 26 histamine histamine NN cord-007445-2folsh35 60 27 5 5 CD cord-007445-2folsh35 60 28 months month NNS cord-007445-2folsh35 60 29 after after IN cord-007445-2folsh35 60 30 bronchiolitis bronchiolitis NN cord-007445-2folsh35 60 31 , , , cord-007445-2folsh35 60 32 and and CC cord-007445-2folsh35 60 33 was be VBD cord-007445-2folsh35 60 34 related relate VBN cord-007445-2folsh35 60 35 to to IN cord-007445-2folsh35 60 36 the the DT cord-007445-2folsh35 60 37 development development NN cord-007445-2folsh35 60 38 of of IN cord-007445-2folsh35 60 39 asthma asthma NN cord-007445-2folsh35 60 40 after after IN cord-007445-2folsh35 60 41 bronchiolitis bronchiolitis NN cord-007445-2folsh35 60 42 in in IN cord-007445-2folsh35 60 43 infants infant NNS cord-007445-2folsh35 60 44 . . . cord-007445-2folsh35 61 1 87 87 CD cord-007445-2folsh35 62 1 In in IN cord-007445-2folsh35 62 2 contrast contrast NN cord-007445-2folsh35 62 3 , , , cord-007445-2folsh35 62 4 other other JJ cord-007445-2folsh35 62 5 groups group NNS cord-007445-2folsh35 62 6 have have VBP cord-007445-2folsh35 62 7 noted note VBN cord-007445-2folsh35 62 8 increased increase VBN cord-007445-2folsh35 62 9 levels level NNS cord-007445-2folsh35 62 10 of of IN cord-007445-2folsh35 62 11 IFN IFN NNP cord-007445-2folsh35 62 12 - - HYPH cord-007445-2folsh35 62 13 y y NNP cord-007445-2folsh35 62 14 respiratory respiratory JJ cord-007445-2folsh35 62 15 tract tract NN cord-007445-2folsh35 62 16 secretions secretion NNS cord-007445-2folsh35 62 17 during during IN cord-007445-2folsh35 62 18 RSV RSV NNP cord-007445-2folsh35 62 19 illnesses illness NNS cord-007445-2folsh35 62 20 in in IN cord-007445-2folsh35 62 21 infants infant NNS cord-007445-2folsh35 62 22 and and CC cord-007445-2folsh35 62 23 children child NNS cord-007445-2folsh35 62 24 with with IN cord-007445-2folsh35 62 25 bronchiolitis bronchiolitis NN cord-007445-2folsh35 62 26 and and CC cord-007445-2folsh35 62 27 recurrent recurrent JJ cord-007445-2folsh35 62 28 wheezing wheezing NN cord-007445-2folsh35 62 29 compared compare VBN cord-007445-2folsh35 62 30 with with IN cord-007445-2folsh35 62 31 those those DT cord-007445-2folsh35 62 32 with with IN cord-007445-2folsh35 62 33 upper upper JJ cord-007445-2folsh35 62 34 respiratory respiratory JJ cord-007445-2folsh35 62 35 tract tract NN cord-007445-2folsh35 62 36 symptoms symptom NNS cord-007445-2folsh35 62 37 Unfortunately unfortunately RB cord-007445-2folsh35 62 38 , , , cord-007445-2folsh35 62 39 in in IN cord-007445-2folsh35 62 40 all all DT cord-007445-2folsh35 62 41 of of IN cord-007445-2folsh35 62 42 the the DT cord-007445-2folsh35 62 43 studies study NNS cord-007445-2folsh35 62 44 reported report VBN cord-007445-2folsh35 62 45 thus thus RB cord-007445-2folsh35 62 46 far far RB cord-007445-2folsh35 62 47 , , , cord-007445-2folsh35 62 48 the the DT cord-007445-2folsh35 62 49 pattern pattern NN cord-007445-2folsh35 62 50 of of IN cord-007445-2folsh35 62 51 cytokine cytokine NN cord-007445-2folsh35 62 52 response response NN cord-007445-2folsh35 62 53 these these DT cord-007445-2folsh35 62 54 infants infant NNS cord-007445-2folsh35 62 55 had have VBD cord-007445-2folsh35 62 56 prior prior RB cord-007445-2folsh35 62 57 to to IN cord-007445-2folsh35 62 58 infection infection NN cord-007445-2folsh35 62 59 was be VBD cord-007445-2folsh35 62 60 not not RB cord-007445-2folsh35 62 61 evaluated evaluate VBN cord-007445-2folsh35 62 62 , , , cord-007445-2folsh35 62 63 begging beg VBG cord-007445-2folsh35 62 64 the the DT cord-007445-2folsh35 62 65 question question NN cord-007445-2folsh35 62 66 as as IN cord-007445-2folsh35 62 67 to to IN cord-007445-2folsh35 62 68 which which WDT cord-007445-2folsh35 62 69 of of IN cord-007445-2folsh35 62 70 the the DT cord-007445-2folsh35 62 71 observed observed JJ cord-007445-2folsh35 62 72 results result NNS cord-007445-2folsh35 62 73 may may MD cord-007445-2folsh35 62 74 be be VB cord-007445-2folsh35 62 75 cause cause NN cord-007445-2folsh35 62 76 and and CC cord-007445-2folsh35 62 77 which which WDT cord-007445-2folsh35 62 78 effect effect NN cord-007445-2folsh35 62 79 . . . cord-007445-2folsh35 63 1 To to TO cord-007445-2folsh35 63 2 more more RBR cord-007445-2folsh35 63 3 comprehensively comprehensively RB cord-007445-2folsh35 63 4 evaluate evaluate VB cord-007445-2folsh35 63 5 the the DT cord-007445-2folsh35 63 6 relationships relationship NNS cord-007445-2folsh35 63 7 among among IN cord-007445-2folsh35 63 8 virus virus NN cord-007445-2folsh35 63 9 infection infection NN cord-007445-2folsh35 63 10 , , , cord-007445-2folsh35 63 11 atopy atopy NN cord-007445-2folsh35 63 12 ( ( -LRB- cord-007445-2folsh35 63 13 cytokine cytokine JJ cord-007445-2folsh35 63 14 dysregulation dysregulation NN cord-007445-2folsh35 63 15 of of IN cord-007445-2folsh35 63 16 Thl Thl NNP cord-007445-2folsh35 63 17 / / SYM cord-007445-2folsh35 63 18 Th2 th2 CD cord-007445-2folsh35 63 19 imbalance imbalance NN cord-007445-2folsh35 63 20 ) ) -RRB- cord-007445-2folsh35 63 21 , , , cord-007445-2folsh35 63 22 and and CC cord-007445-2folsh35 63 23 immune immune JJ cord-007445-2folsh35 63 24 system system NN cord-007445-2folsh35 63 25 or or CC cord-007445-2folsh35 63 26 lung lung NN cord-007445-2folsh35 63 27 developmental developmental JJ cord-007445-2folsh35 63 28 components component NNS cord-007445-2folsh35 63 29 , , , cord-007445-2folsh35 63 30 a a DT cord-007445-2folsh35 63 31 rat rat NN cord-007445-2folsh35 63 32 model model NN cord-007445-2folsh35 63 33 of of IN cord-007445-2folsh35 63 34 virus virus NN cord-007445-2folsh35 63 35 - - HYPH cord-007445-2folsh35 63 36 induced induce VBN cord-007445-2folsh35 63 37 airway airway NN cord-007445-2folsh35 63 38 dysfunction dysfunction NN cord-007445-2folsh35 63 39 has have VBZ cord-007445-2folsh35 63 40 been be VBN cord-007445-2folsh35 63 41 studied study VBN cord-007445-2folsh35 63 42 extensively extensively RB cord-007445-2folsh35 63 43 . . . cord-007445-2folsh35 64 1 ' ' `` cord-007445-2folsh35 64 2 l l NN cord-007445-2folsh35 64 3 ' ' '' cord-007445-2folsh35 65 1 In in IN cord-007445-2folsh35 65 2 this this DT cord-007445-2folsh35 65 3 model model NN cord-007445-2folsh35 65 4 , , , cord-007445-2folsh35 65 5 infection infection NN cord-007445-2folsh35 65 6 with with IN cord-007445-2folsh35 65 7 PIV PIV NNP cord-007445-2folsh35 65 8 type type NN cord-007445-2folsh35 65 9 1 1 CD cord-007445-2folsh35 65 10 during during IN cord-007445-2folsh35 65 11 a a DT cord-007445-2folsh35 65 12 critical critical JJ cord-007445-2folsh35 65 13 developmental developmental JJ cord-007445-2folsh35 65 14 time time NN cord-007445-2folsh35 65 15 period period NN cord-007445-2folsh35 65 16 ( ( -LRB- cord-007445-2folsh35 65 17 when when WRB cord-007445-2folsh35 65 18 the the DT cord-007445-2folsh35 65 19 animals animal NNS cord-007445-2folsh35 65 20 are be VBP cord-007445-2folsh35 65 21 weaning wean VBG cord-007445-2folsh35 65 22 [ [ -LRB- cord-007445-2folsh35 65 23 3 3 CD cord-007445-2folsh35 65 24 4 4 CD cord-007445-2folsh35 65 25 weeks week NNS cord-007445-2folsh35 65 26 of of IN cord-007445-2folsh35 65 27 age age NN cord-007445-2folsh35 65 28 ] ] -RRB- cord-007445-2folsh35 65 29 as as IN cord-007445-2folsh35 65 30 opposed oppose VBN cord-007445-2folsh35 65 31 to to IN cord-007445-2folsh35 65 32 when when WRB cord-007445-2folsh35 65 33 they -PRON- PRP cord-007445-2folsh35 65 34 are be VBP cord-007445-2folsh35 65 35 neonates neonate NNS cord-007445-2folsh35 65 36 [ [ -LRB- cord-007445-2folsh35 65 37 4 4 CD cord-007445-2folsh35 65 38 - - SYM cord-007445-2folsh35 65 39 5 5 CD cord-007445-2folsh35 65 40 days day NNS cord-007445-2folsh35 65 41 ] ] -RRB- cord-007445-2folsh35 65 42 or or CC cord-007445-2folsh35 65 43 adults adult NNS cord-007445-2folsh35 65 44 ) ) -RRB- cord-007445-2folsh35 65 45 produces produce VBZ cord-007445-2folsh35 65 46 chronic chronic NN cord-007445-2folsh35 65 47 ( ( -LRB- cord-007445-2folsh35 65 48 8 8 CD cord-007445-2folsh35 65 49 - - SYM cord-007445-2folsh35 65 50 12 12 CD cord-007445-2folsh35 65 51 weeks week NNS cord-007445-2folsh35 65 52 fol fol NN cord-007445-2folsh35 65 53 - - HYPH cord-007445-2folsh35 65 54 lowing low VBG cord-007445-2folsh35 65 55 infection infection NN cord-007445-2folsh35 65 56 ) ) -RRB- cord-007445-2folsh35 65 57 , , , cord-007445-2folsh35 65 58 episodic episodic JJ cord-007445-2folsh35 65 59 , , , cord-007445-2folsh35 65 60 reversible reversible JJ cord-007445-2folsh35 65 61 airway airway NN cord-007445-2folsh35 65 62 inflammation inflammation NN cord-007445-2folsh35 65 63 and and CC cord-007445-2folsh35 65 64 remodeling remodeling NN cord-007445-2folsh35 65 65 with with IN cord-007445-2folsh35 65 66 associated associated JJ cord-007445-2folsh35 65 67 alterations alteration NNS cord-007445-2folsh35 65 68 in in IN cord-007445-2folsh35 65 69 airway airway NN cord-007445-2folsh35 65 70 physiology physiology NN cord-007445-2folsh35 65 71 ( ( -LRB- cord-007445-2folsh35 65 72 increased increase VBN cord-007445-2folsh35 65 73 resistance resistance NN cord-007445-2folsh35 65 74 and and CC cord-007445-2folsh35 65 75 rnethacholine rnethacholine NN cord-007445-2folsh35 65 76 responsiveness responsiveness NN cord-007445-2folsh35 65 77 ) ) -RRB- cord-007445-2folsh35 65 78 that that WDT cord-007445-2folsh35 65 79 resemble resemble VBP cord-007445-2folsh35 65 80 human human JJ cord-007445-2folsh35 65 81 asthma asthma NN cord-007445-2folsh35 65 82 in in IN cord-007445-2folsh35 65 83 high high JJ cord-007445-2folsh35 65 84 ( ( -LRB- cord-007445-2folsh35 65 85 brown brown JJ cord-007445-2folsh35 65 86 Norway Norway NNP cord-007445-2folsh35 65 87 strain strain NN cord-007445-2folsh35 65 88 ) ) -RRB- cord-007445-2folsh35 65 89 but but CC cord-007445-2folsh35 65 90 not not RB cord-007445-2folsh35 65 91 low low JJ cord-007445-2folsh35 65 92 ( ( -LRB- cord-007445-2folsh35 65 93 F344 f344 CD cord-007445-2folsh35 65 94 strain strain NN cord-007445-2folsh35 65 95 ) ) -RRB- cord-007445-2folsh35 65 96 IgEantibody IgEantibody NNP cord-007445-2folsh35 65 97 producing produce VBG cord-007445-2folsh35 65 98 rats.62 rats.62 NNP cord-007445-2folsh35 66 1 The the DT cord-007445-2folsh35 66 2 temporal temporal JJ cord-007445-2folsh35 66 3 progression progression NN cord-007445-2folsh35 66 4 of of IN cord-007445-2folsh35 66 5 this this DT cord-007445-2folsh35 66 6 asthma asthma NN cord-007445-2folsh35 66 7 - - HYPH cord-007445-2folsh35 66 8 like like JJ cord-007445-2folsh35 66 9 syndrome syndrome NN cord-007445-2folsh35 66 10 is be VBZ cord-007445-2folsh35 66 11 associated associate VBN cord-007445-2folsh35 66 12 with with IN cord-007445-2folsh35 66 13 a a DT cord-007445-2folsh35 66 14 Thl Thl NNP cord-007445-2folsh35 66 15 / / SYM cord-007445-2folsh35 66 16 Th2 th2 CD cord-007445-2folsh35 66 17 imbalance imbalance NN cord-007445-2folsh35 66 18 within within IN cord-007445-2folsh35 66 19 the the DT cord-007445-2folsh35 66 20 lung lung NN cord-007445-2folsh35 66 21 , , , cord-007445-2folsh35 66 22 and and CC cord-007445-2folsh35 66 23 its -PRON- PRP$ cord-007445-2folsh35 66 24 development development NN cord-007445-2folsh35 66 25 can can MD cord-007445-2folsh35 66 26 be be VB cord-007445-2folsh35 66 27 significantly significantly RB cord-007445-2folsh35 66 28 attenuated attenuate VBN cord-007445-2folsh35 66 29 by by IN cord-007445-2folsh35 66 30 the the DT cord-007445-2folsh35 66 31 exogenous exogenous JJ cord-007445-2folsh35 66 32 administration administration NN cord-007445-2folsh35 66 33 of of IN cord-007445-2folsh35 66 34 IFN-8 IFN-8 NNP cord-007445-2folsh35 66 35 just just RB cord-007445-2folsh35 66 36 prior prior RB cord-007445-2folsh35 66 37 to to IN cord-007445-2folsh35 66 38 and and CC cord-007445-2folsh35 66 39 during during IN cord-007445-2folsh35 66 40 the the DT cord-007445-2folsh35 66 41 viral viral JJ cord-007445-2folsh35 66 42 infection infection NN cord-007445-2folsh35 66 43 in in IN cord-007445-2folsh35 66 44 the the DT cord-007445-2folsh35 66 45 brown brown JJ cord-007445-2folsh35 66 46 Norway Norway NNP cord-007445-2folsh35 66 47 responder responder NN cord-007445-2folsh35 66 48 strain.lo2 strain.lo2 ADD cord-007445-2folsh35 67 1 This this DT cord-007445-2folsh35 67 2 model model NN cord-007445-2folsh35 67 3 further further RB cord-007445-2folsh35 67 4 supports support VBZ cord-007445-2folsh35 67 5 the the DT cord-007445-2folsh35 67 6 concept concept NN cord-007445-2folsh35 67 7 of of IN cord-007445-2folsh35 67 8 both both DT cord-007445-2folsh35 67 9 genetic genetic JJ cord-007445-2folsh35 67 10 ( ( -LRB- cord-007445-2folsh35 67 11 atopy atopy NN cord-007445-2folsh35 67 12 ; ; , cord-007445-2folsh35 67 13 cytokine cytokine NN cord-007445-2folsh35 67 14 dysregulation dysregulation NN cord-007445-2folsh35 67 15 or or CC cord-007445-2folsh35 67 16 imbalance imbalance NN cord-007445-2folsh35 67 17 ) ) -RRB- cord-007445-2folsh35 67 18 and and CC cord-007445-2folsh35 67 19 environmental environmental JJ cord-007445-2folsh35 67 20 factors factor NNS cord-007445-2folsh35 67 21 ( ( -LRB- cord-007445-2folsh35 67 22 virus virus NN cord-007445-2folsh35 67 23 infection infection NN cord-007445-2folsh35 67 24 ) ) -RRB- cord-007445-2folsh35 67 25 being be VBG cord-007445-2folsh35 67 26 important important JJ cord-007445-2folsh35 67 27 in in IN cord-007445-2folsh35 67 28 the the DT cord-007445-2folsh35 67 29 inception inception NN cord-007445-2folsh35 67 30 of of IN cord-007445-2folsh35 67 31 the the DT cord-007445-2folsh35 67 32 asthmatic asthmatic JJ cord-007445-2folsh35 67 33 phenotype phenotype NN cord-007445-2folsh35 67 34 , , , cord-007445-2folsh35 67 35 as as RB cord-007445-2folsh35 67 36 well well RB cord-007445-2folsh35 67 37 as as IN cord-007445-2folsh35 67 38 a a DT cord-007445-2folsh35 67 39 developmental developmental JJ cord-007445-2folsh35 67 40 component component NN cord-007445-2folsh35 67 41 contributing contribute VBG cord-007445-2folsh35 67 42 . . . cord-007445-2folsh35 68 1 Respiratory respiratory JJ cord-007445-2folsh35 68 2 viruses virus NNS cord-007445-2folsh35 68 3 are be VBP cord-007445-2folsh35 68 4 common common JJ cord-007445-2folsh35 68 5 causes cause NNS cord-007445-2folsh35 68 6 of of IN cord-007445-2folsh35 68 7 asthma asthma NN cord-007445-2folsh35 68 8 exacerbations exacerbation NNS cord-007445-2folsh35 68 9 in in IN cord-007445-2folsh35 68 10 asthmatic asthmatic JJ cord-007445-2folsh35 68 11 subjects subject NNS cord-007445-2folsh35 68 12 of of IN cord-007445-2folsh35 68 13 different different JJ cord-007445-2folsh35 68 14 age age NN cord-007445-2folsh35 68 15 74 74 CD cord-007445-2folsh35 68 16 , , , cord-007445-2folsh35 68 17 86 86 CD cord-007445-2folsh35 68 18 Serology serology NN cord-007445-2folsh35 68 19 or or CC cord-007445-2folsh35 68 20 culture culture NN cord-007445-2folsh35 68 21 detection detection NN cord-007445-2folsh35 68 22 methods method NNS cord-007445-2folsh35 68 23 of of IN cord-007445-2folsh35 68 24 viruses virus NNS cord-007445-2folsh35 68 25 initially initially RB cord-007445-2folsh35 68 26 indicated indicate VBD cord-007445-2folsh35 68 27 an an DT cord-007445-2folsh35 68 28 association association NN cord-007445-2folsh35 68 29 during during IN cord-007445-2folsh35 68 30 asthma asthma NNP cord-007445-2folsh35 68 31 exacerba exacerba NNP cord-007445-2folsh35 68 32 - - HYPH cord-007445-2folsh35 68 33 tionss2 tionss2 NNP cord-007445-2folsh35 68 34 despite despite IN cord-007445-2folsh35 68 35 the the DT cord-007445-2folsh35 68 36 fact fact NN cord-007445-2folsh35 68 37 that that IN cord-007445-2folsh35 68 38 these these DT cord-007445-2folsh35 68 39 detection detection NN cord-007445-2folsh35 68 40 methods method NNS cord-007445-2folsh35 68 41 are be VBP cord-007445-2folsh35 68 42 relatively relatively RB cord-007445-2folsh35 68 43 insensitive insensitive JJ cord-007445-2folsh35 68 44 for for IN cord-007445-2folsh35 68 45 viruses virus NNS cord-007445-2folsh35 68 46 such such JJ cord-007445-2folsh35 68 47 as as IN cord-007445-2folsh35 68 48 rhinovirus rhinovirus NN cord-007445-2folsh35 68 49 ( ( -LRB- cord-007445-2folsh35 68 50 RV RV NNP cord-007445-2folsh35 68 51 ) ) -RRB- cord-007445-2folsh35 68 52 . . . cord-007445-2folsh35 69 1 The the DT cord-007445-2folsh35 69 2 use use NN cord-007445-2folsh35 69 3 of of IN cord-007445-2folsh35 69 4 reverse reverse JJ cord-007445-2folsh35 69 5 transcription transcription NN cord-007445-2folsh35 69 6 polymerase polymerase NN cord-007445-2folsh35 69 7 chain chain NN cord-007445-2folsh35 69 8 reaction reaction NN cord-007445-2folsh35 69 9 ( ( -LRB- cord-007445-2folsh35 69 10 RT RT NNP cord-007445-2folsh35 69 11 - - HYPH cord-007445-2folsh35 69 12 PCR PCR NNP cord-007445-2folsh35 69 13 ) ) -RRB- cord-007445-2folsh35 69 14 assays assay NNS cord-007445-2folsh35 69 15 that that WDT cord-007445-2folsh35 69 16 are be VBP cord-007445-2folsh35 69 17 more more RBR cord-007445-2folsh35 69 18 sensitive sensitive JJ cord-007445-2folsh35 69 19 for for IN cord-007445-2folsh35 69 20 detection detection NN cord-007445-2folsh35 69 21 of of IN cord-007445-2folsh35 69 22 RV RV NNP cord-007445-2folsh35 69 23 have have VBP cord-007445-2folsh35 69 24 confirmed confirm VBN cord-007445-2folsh35 69 25 and and CC cord-007445-2folsh35 69 26 expanded expand VBN cord-007445-2folsh35 69 27 these these DT cord-007445-2folsh35 69 28 initial initial JJ cord-007445-2folsh35 69 29 observation^.^^ observation^.^^ NN cord-007445-2folsh35 70 1 Indeed indeed RB cord-007445-2folsh35 70 2 , , , cord-007445-2folsh35 70 3 Johnston Johnston NNP cord-007445-2folsh35 70 4 et et NNP cord-007445-2folsh35 70 5 a157 a157 NNP cord-007445-2folsh35 70 6 found find VBD cord-007445-2folsh35 70 7 that that IN cord-007445-2folsh35 70 8 80 80 CD cord-007445-2folsh35 70 9 % % NN cord-007445-2folsh35 70 10 to to TO cord-007445-2folsh35 70 11 85 85 CD cord-007445-2folsh35 70 12 % % NN cord-007445-2folsh35 70 13 of of IN cord-007445-2folsh35 70 14 school school NN cord-007445-2folsh35 70 15 - - HYPH cord-007445-2folsh35 70 16 aged age VBN cord-007445-2folsh35 70 17 children child NNS cord-007445-2folsh35 70 18 with with IN cord-007445-2folsh35 70 19 acute acute JJ cord-007445-2folsh35 70 20 wheezing wheezing JJ cord-007445-2folsh35 70 21 episodes episode NNS cord-007445-2folsh35 70 22 tested test VBD cord-007445-2folsh35 70 23 positive positive JJ cord-007445-2folsh35 70 24 for for IN cord-007445-2folsh35 70 25 a a DT cord-007445-2folsh35 70 26 virus virus NN cord-007445-2folsh35 70 27 using use VBG cord-007445-2folsh35 70 28 RT RT NNP cord-007445-2folsh35 70 29 - - HYPH cord-007445-2folsh35 70 30 PCR PCR NNP cord-007445-2folsh35 70 31 and and CC cord-007445-2folsh35 70 32 other other JJ cord-007445-2folsh35 70 33 standard standard JJ cord-007445-2folsh35 70 34 virologic virologic JJ cord-007445-2folsh35 70 35 techniques technique NNS cord-007445-2folsh35 70 36 . . . cord-007445-2folsh35 71 1 The the DT cord-007445-2folsh35 71 2 virus virus NN cord-007445-2folsh35 71 3 most most RBS cord-007445-2folsh35 71 4 often often RB cord-007445-2folsh35 71 5 detected detect VBN cord-007445-2folsh35 71 6 was be VBD cord-007445-2folsh35 71 7 RV RV NNP cord-007445-2folsh35 71 8 . . . cord-007445-2folsh35 72 1 Seasonal seasonal JJ cord-007445-2folsh35 72 2 patterns pattern NNS cord-007445-2folsh35 72 3 of of IN cord-007445-2folsh35 72 4 upper upper JJ cord-007445-2folsh35 72 5 respiratory respiratory JJ cord-007445-2folsh35 72 6 virus virus NN cord-007445-2folsh35 72 7 infections infection NNS cord-007445-2folsh35 72 8 correlate correlate VBP cord-007445-2folsh35 72 9 closely closely RB cord-007445-2folsh35 72 10 with with IN cord-007445-2folsh35 72 11 hospital hospital NN cord-007445-2folsh35 72 12 admissions admission NNS cord-007445-2folsh35 72 13 for for IN cord-007445-2folsh35 72 14 asthma asthma NN cord-007445-2folsh35 72 15 , , , cord-007445-2folsh35 72 16 particularly particularly RB cord-007445-2folsh35 72 17 in in IN cord-007445-2folsh35 72 18 pediatric pediatric JJ cord-007445-2folsh35 72 19 age age NN cord-007445-2folsh35 73 1 These these DT cord-007445-2folsh35 73 2 studies study NNS cord-007445-2folsh35 73 3 indicate indicate VBP cord-007445-2folsh35 73 4 that that IN cord-007445-2folsh35 73 5 RV RV NNP cord-007445-2folsh35 73 6 infections infection NNS cord-007445-2folsh35 73 7 are be VBP cord-007445-2folsh35 73 8 the the DT cord-007445-2folsh35 73 9 most most RBS cord-007445-2folsh35 73 10 common common JJ cord-007445-2folsh35 73 11 cause cause NN cord-007445-2folsh35 73 12 of of IN cord-007445-2folsh35 73 13 asthma asthma NN cord-007445-2folsh35 73 14 exacerbations exacerbation NNS cord-007445-2folsh35 73 15 in in IN cord-007445-2folsh35 73 16 children child NNS cord-007445-2folsh35 73 17 , , , cord-007445-2folsh35 73 18 especially especially RB cord-007445-2folsh35 73 19 during during IN cord-007445-2folsh35 73 20 spring spring NN cord-007445-2folsh35 73 21 and and CC cord-007445-2folsh35 73 22 fall fall VB cord-007445-2folsh35 73 23 . . . cord-007445-2folsh35 74 1 Similar similar JJ cord-007445-2folsh35 74 2 studies study NNS cord-007445-2folsh35 74 3 , , , cord-007445-2folsh35 74 4 performed perform VBN cord-007445-2folsh35 74 5 in in IN cord-007445-2folsh35 74 6 found find VBN cord-007445-2folsh35 74 7 that that IN cord-007445-2folsh35 74 8 about about IN cord-007445-2folsh35 74 9 half half NN cord-007445-2folsh35 74 10 of of IN cord-007445-2folsh35 74 11 asthma asthma NN cord-007445-2folsh35 74 12 exacerbations exacerbation NNS cord-007445-2folsh35 74 13 were be VBD cord-007445-2folsh35 74 14 associated associate VBN cord-007445-2folsh35 74 15 with with IN cord-007445-2folsh35 74 16 RV rv NN cord-007445-2folsh35 74 17 infection infection NN cord-007445-2folsh35 74 18 . . . cord-007445-2folsh35 75 1 As as IN cord-007445-2folsh35 75 2 discussed discuss VBN cord-007445-2folsh35 75 3 previously previously RB cord-007445-2folsh35 75 4 , , , cord-007445-2folsh35 75 5 in in IN cord-007445-2folsh35 75 6 infancy infancy NN cord-007445-2folsh35 75 7 , , , cord-007445-2folsh35 75 8 atopy atopy NN cord-007445-2folsh35 75 9 may may MD cord-007445-2folsh35 75 10 define define VB cord-007445-2folsh35 75 11 a a DT cord-007445-2folsh35 75 12 susceptibility susceptibility NN cord-007445-2folsh35 75 13 of of IN cord-007445-2folsh35 75 14 the the DT cord-007445-2folsh35 75 15 host host NN cord-007445-2folsh35 75 16 to to IN cord-007445-2folsh35 75 17 wheezing wheeze VBG cord-007445-2folsh35 75 18 with with IN cord-007445-2folsh35 75 19 respiratory respiratory JJ cord-007445-2folsh35 75 20 infections infection NNS cord-007445-2folsh35 75 21 . . . cord-007445-2folsh35 76 1 Duff Duff NNP cord-007445-2folsh35 76 2 et et NNP cord-007445-2folsh35 76 3 a1,= a1,= NNP cord-007445-2folsh35 76 4 for for IN cord-007445-2folsh35 76 5 example example NN cord-007445-2folsh35 76 6 , , , cord-007445-2folsh35 76 7 studied study VBD cord-007445-2folsh35 76 8 children child NNS cord-007445-2folsh35 76 9 who who WP cord-007445-2folsh35 76 10 presented present VBD cord-007445-2folsh35 76 11 to to IN cord-007445-2folsh35 76 12 an an DT cord-007445-2folsh35 76 13 emergency emergency NN cord-007445-2folsh35 76 14 department department NN cord-007445-2folsh35 76 15 with with IN cord-007445-2folsh35 76 16 wheezing wheeze VBG cord-007445-2folsh35 76 17 . . . cord-007445-2folsh35 77 1 Children child NNS cord-007445-2folsh35 77 2 over over IN cord-007445-2folsh35 77 3 2 2 CD cord-007445-2folsh35 77 4 years year NNS cord-007445-2folsh35 77 5 of of IN cord-007445-2folsh35 77 6 age age NN cord-007445-2folsh35 77 7 were be VBD cord-007445-2folsh35 77 8 more more RBR cord-007445-2folsh35 77 9 likely likely JJ cord-007445-2folsh35 77 10 to to TO cord-007445-2folsh35 77 11 have have VB cord-007445-2folsh35 77 12 respiratory respiratory JJ cord-007445-2folsh35 77 13 allergies allergy NNS cord-007445-2folsh35 77 14 or or CC cord-007445-2folsh35 77 15 a a DT cord-007445-2folsh35 77 16 confirmed confirm VBN cord-007445-2folsh35 77 17 respiratory respiratory JJ cord-007445-2folsh35 77 18 viral viral JJ cord-007445-2folsh35 77 19 infection infection NN cord-007445-2folsh35 77 20 compared compare VBN cord-007445-2folsh35 77 21 with with IN cord-007445-2folsh35 77 22 children child NNS cord-007445-2folsh35 77 23 with with IN cord-007445-2folsh35 77 24 no no DT cord-007445-2folsh35 77 25 wheezing wheezing NN cord-007445-2folsh35 77 26 . . . cord-007445-2folsh35 78 1 Children child NNS cord-007445-2folsh35 78 2 with with IN cord-007445-2folsh35 78 3 the the DT cord-007445-2folsh35 78 4 highest high JJS cord-007445-2folsh35 78 5 risk risk NN cord-007445-2folsh35 78 6 for for IN cord-007445-2folsh35 78 7 wheezing wheeze VBG cord-007445-2folsh35 78 8 were be VBD cord-007445-2folsh35 78 9 those those DT cord-007445-2folsh35 78 10 who who WP cord-007445-2folsh35 78 11 had have VBD cord-007445-2folsh35 78 12 respiratory respiratory JJ cord-007445-2folsh35 78 13 allergies allergy NNS cord-007445-2folsh35 78 14 and and CC cord-007445-2folsh35 78 15 respiratory respiratory JJ cord-007445-2folsh35 78 16 viral viral JJ cord-007445-2folsh35 78 17 infection infection NN cord-007445-2folsh35 78 18 , , , cord-007445-2folsh35 78 19 implying imply VBG cord-007445-2folsh35 78 20 that that IN cord-007445-2folsh35 78 21 respiratory respiratory JJ cord-007445-2folsh35 78 22 viral viral JJ cord-007445-2folsh35 78 23 infections infection NNS cord-007445-2folsh35 78 24 and and CC cord-007445-2folsh35 78 25 respiratory respiratory JJ cord-007445-2folsh35 78 26 allergies allergy NNS cord-007445-2folsh35 78 27 may may MD cord-007445-2folsh35 78 28 have have VB cord-007445-2folsh35 78 29 synergistic synergistic JJ cord-007445-2folsh35 78 30 effects effect NNS cord-007445-2folsh35 78 31 on on IN cord-007445-2folsh35 78 32 lower low JJR cord-007445-2folsh35 78 33 airway airway NN cord-007445-2folsh35 78 34 physiology physiology NN cord-007445-2folsh35 78 35 and and CC cord-007445-2folsh35 78 36 enhance enhance VB cord-007445-2folsh35 78 37 the the DT cord-007445-2folsh35 78 38 likelihood likelihood NN cord-007445-2folsh35 78 39 of of IN cord-007445-2folsh35 78 40 wheezing wheeze VBG cord-007445-2folsh35 78 41 with with IN cord-007445-2folsh35 78 42 respiratory respiratory JJ cord-007445-2folsh35 78 43 infection infection NN cord-007445-2folsh35 78 44 . . . cord-007445-2folsh35 79 1 In in IN cord-007445-2folsh35 79 2 children child NNS cord-007445-2folsh35 79 3 less less JJR cord-007445-2folsh35 79 4 than than IN cord-007445-2folsh35 79 5 2 2 CD cord-007445-2folsh35 79 6 years year NNS cord-007445-2folsh35 79 7 of of IN cord-007445-2folsh35 79 8 age age NN cord-007445-2folsh35 79 9 , , , cord-007445-2folsh35 79 10 wheezing wheeze VBG cord-007445-2folsh35 79 11 was be VBD cord-007445-2folsh35 79 12 also also RB cord-007445-2folsh35 79 13 noted note VBN cord-007445-2folsh35 79 14 , , , cord-007445-2folsh35 79 15 but but CC cord-007445-2folsh35 79 16 risk risk NN cord-007445-2folsh35 79 17 factors factor NNS cord-007445-2folsh35 79 18 for for IN cord-007445-2folsh35 79 19 wheezing wheeze VBG cord-007445-2folsh35 79 20 were be VBD cord-007445-2folsh35 79 21 quite quite RB cord-007445-2folsh35 79 22 different different JJ cord-007445-2folsh35 79 23 . . . cord-007445-2folsh35 80 1 These these DT cord-007445-2folsh35 80 2 infants infant NNS cord-007445-2folsh35 80 3 were be VBD cord-007445-2folsh35 80 4 not not RB cord-007445-2folsh35 80 5 allergic allergic JJ cord-007445-2folsh35 80 6 , , , cord-007445-2folsh35 80 7 had have VBD cord-007445-2folsh35 80 8 RSV RSV NNP cord-007445-2folsh35 80 9 as as IN cord-007445-2folsh35 80 10 the the DT cord-007445-2folsh35 80 11 major major JJ cord-007445-2folsh35 80 12 viral viral JJ cord-007445-2folsh35 80 13 isolate isolate NN cord-007445-2folsh35 80 14 , , , cord-007445-2folsh35 80 15 and and CC cord-007445-2folsh35 80 16 had have VBD cord-007445-2folsh35 80 17 passive passive JJ cord-007445-2folsh35 80 18 tobacco tobacco NN cord-007445-2folsh35 80 19 smoke smoke NN cord-007445-2folsh35 80 20 exposure exposure NN cord-007445-2folsh35 80 21 as as IN cord-007445-2folsh35 80 22 a a DT cord-007445-2folsh35 80 23 major major JJ cord-007445-2folsh35 80 24 risk risk NN cord-007445-2folsh35 80 25 factor factor NN cord-007445-2folsh35 80 26 for for IN cord-007445-2folsh35 80 27 wheezing wheeze VBG cord-007445-2folsh35 80 28 . . . cord-007445-2folsh35 81 1 Available available JJ cord-007445-2folsh35 81 2 epidemiologic epidemiologic JJ cord-007445-2folsh35 81 3 data datum NNS cord-007445-2folsh35 81 4 in in IN cord-007445-2folsh35 81 5 children child NNS cord-007445-2folsh35 81 6 and and CC cord-007445-2folsh35 81 7 adults adult NNS cord-007445-2folsh35 81 8 have have VBP cord-007445-2folsh35 81 9 shown show VBN cord-007445-2folsh35 81 10 that that IN cord-007445-2folsh35 81 11 episodic episodic JJ cord-007445-2folsh35 81 12 drops drop NNS cord-007445-2folsh35 81 13 in in IN cord-007445-2folsh35 81 14 peak peak JJ cord-007445-2folsh35 81 15 flow flow NN cord-007445-2folsh35 81 16 measurements measurement NNS cord-007445-2folsh35 81 17 are be VBP cord-007445-2folsh35 81 18 associated associate VBN cord-007445-2folsh35 81 19 with with IN cord-007445-2folsh35 81 20 RV RV NNP cord-007445-2folsh35 81 21 infections infection NNS cord-007445-2folsh35 81 22 . . . cord-007445-2folsh35 82 1 This this DT cord-007445-2folsh35 82 2 was be VBD cord-007445-2folsh35 82 3 found find VBN cord-007445-2folsh35 82 4 to to TO cord-007445-2folsh35 82 5 correlate correlate VB cord-007445-2folsh35 82 6 with with IN cord-007445-2folsh35 82 7 an an DT cord-007445-2folsh35 82 8 increase increase NN cord-007445-2folsh35 82 9 in in IN cord-007445-2folsh35 82 10 asthma asthma NN cord-007445-2folsh35 82 11 symptoms symptom NNS cord-007445-2folsh35 82 12 and and CC cord-007445-2folsh35 82 13 nonspecific nonspecific JJ cord-007445-2folsh35 82 14 airway airway NN cord-007445-2folsh35 82 15 hyperresponsiveness hyperresponsiveness NN cord-007445-2folsh35 82 16 following follow VBG cord-007445-2folsh35 82 17 experimentally experimentally RB cord-007445-2folsh35 82 18 infecting infect VBG cord-007445-2folsh35 82 19 asthmatic asthmatic JJ cord-007445-2folsh35 82 20 subjects subject NNS cord-007445-2folsh35 82 21 with with IN cord-007445-2folsh35 82 22 RV.15 rv.15 NN cord-007445-2folsh35 82 23 , , , cord-007445-2folsh35 83 1 41 41 CD cord-007445-2folsh35 83 2 Further further JJ cord-007445-2folsh35 83 3 studies study NNS cord-007445-2folsh35 83 4 by by IN cord-007445-2folsh35 83 5 Griinberg Griinberg NNP cord-007445-2folsh35 83 6 et et NNP cord-007445-2folsh35 83 7 a140 a140 NNP cord-007445-2folsh35 83 8 demonstrated demonstrate VBD cord-007445-2folsh35 83 9 that that IN cord-007445-2folsh35 83 10 experimental experimental JJ cord-007445-2folsh35 83 11 RV16 RV16 NNP cord-007445-2folsh35 83 12 infection infection NN cord-007445-2folsh35 83 13 leads lead VBZ cord-007445-2folsh35 83 14 to to IN cord-007445-2folsh35 83 15 a a DT cord-007445-2folsh35 83 16 transient transient JJ cord-007445-2folsh35 83 17 drop drop NN cord-007445-2folsh35 83 18 in in IN cord-007445-2folsh35 83 19 daily daily JJ cord-007445-2folsh35 83 20 home home NN cord-007445-2folsh35 83 21 recordings recording NNS cord-007445-2folsh35 83 22 of of IN cord-007445-2folsh35 83 23 FEV FEV NNP cord-007445-2folsh35 83 24 , , , cord-007445-2folsh35 83 25 in in IN cord-007445-2folsh35 83 26 subjects subject NNS cord-007445-2folsh35 83 27 with with IN cord-007445-2folsh35 83 28 asthma asthma NN cord-007445-2folsh35 83 29 . . . cord-007445-2folsh35 84 1 This this DT cord-007445-2folsh35 84 2 variable variable JJ cord-007445-2folsh35 84 3 airway airway NN cord-007445-2folsh35 84 4 obstruction obstruction NN cord-007445-2folsh35 84 5 correlated correlate VBD cord-007445-2folsh35 84 6 significantly significantly RB cord-007445-2folsh35 84 7 with with IN cord-007445-2folsh35 84 8 cold cold JJ cord-007445-2folsh35 84 9 symptoms symptom NNS cord-007445-2folsh35 84 10 , , , cord-007445-2folsh35 84 11 asthma asthma NN cord-007445-2folsh35 84 12 symptoms symptom NNS cord-007445-2folsh35 84 13 , , , cord-007445-2folsh35 84 14 and and CC cord-007445-2folsh35 84 15 the the DT cord-007445-2folsh35 84 16 increase increase NN cord-007445-2folsh35 84 17 in in IN cord-007445-2folsh35 84 18 airway airway NN cord-007445-2folsh35 84 19 hyperresponsiveness hyperresponsiveness NNP cord-007445-2folsh35 84 20 to to IN cord-007445-2folsh35 84 21 histamine histamine NN cord-007445-2folsh35 84 22 . . . cord-007445-2folsh35 85 1 Such such JJ cord-007445-2folsh35 85 2 daily daily JJ cord-007445-2folsh35 85 3 variability variability NN cord-007445-2folsh35 85 4 in in IN cord-007445-2folsh35 85 5 FEV FEV NNP cord-007445-2folsh35 85 6 , , , cord-007445-2folsh35 85 7 reflects reflect VBZ cord-007445-2folsh35 85 8 the the DT cord-007445-2folsh35 85 9 inflammatory inflammatory JJ cord-007445-2folsh35 85 10 changes change NNS cord-007445-2folsh35 85 11 within within IN cord-007445-2folsh35 85 12 the the DT cord-007445-2folsh35 85 13 airway airway NN cord-007445-2folsh35 85 14 wall wall NN cord-007445-2folsh35 85 15 , , , cord-007445-2folsh35 85 16 which which WDT cord-007445-2folsh35 85 17 can can MD cord-007445-2folsh35 85 18 be be VB cord-007445-2folsh35 85 19 induced induce VBN cord-007445-2folsh35 85 20 by by IN cord-007445-2folsh35 85 21 the the DT cord-007445-2folsh35 85 22 natural natural JJ cord-007445-2folsh35 85 23 RV RV NNP cord-007445-2folsh35 85 24 infection infection NN cord-007445-2folsh35 85 25 . . . cord-007445-2folsh35 86 1 following follow VBG cord-007445-2folsh35 86 2 infections infection NNS cord-007445-2folsh35 86 3 with with IN cord-007445-2folsh35 86 4 RV8 rv8 NN cord-007445-2folsh35 86 5 and and CC cord-007445-2folsh35 86 6 influenza influenza NN cord-007445-2folsh35 86 7 A.@ A.@ NNP cord-007445-2folsh35 86 8 , , , cord-007445-2folsh35 86 9 72 72 CD cord-007445-2folsh35 86 10 In in IN cord-007445-2folsh35 86 11 a a DT cord-007445-2folsh35 86 12 study study NN cord-007445-2folsh35 86 13 by by IN cord-007445-2folsh35 86 14 Cheung Cheung NNP cord-007445-2folsh35 86 15 et et NNP cord-007445-2folsh35 86 16 all5 all5 NN cord-007445-2folsh35 86 17 14 14 CD cord-007445-2folsh35 86 18 subjects subject NNS cord-007445-2folsh35 86 19 with with IN cord-007445-2folsh35 86 20 mild mild JJ cord-007445-2folsh35 86 21 asthma asthma NNS cord-007445-2folsh35 86 22 were be VBD cord-007445-2folsh35 86 23 inoculated inoculate VBN cord-007445-2folsh35 86 24 with with IN cord-007445-2folsh35 86 25 RV16 RV16 NNP cord-007445-2folsh35 86 26 or or CC cord-007445-2folsh35 86 27 placebo placebo NN cord-007445-2folsh35 86 28 . . . cord-007445-2folsh35 87 1 The the DT cord-007445-2folsh35 87 2 maximal maximal JJ cord-007445-2folsh35 87 3 contractile contractile JJ cord-007445-2folsh35 87 4 response response NN cord-007445-2folsh35 87 5 to to IN cord-007445-2folsh35 87 6 inhaled inhale VBN cord-007445-2folsh35 87 7 methacholine methacholine NN cord-007445-2folsh35 87 8 was be VBD cord-007445-2folsh35 87 9 significantly significantly RB cord-007445-2folsh35 87 10 greater great JJR cord-007445-2folsh35 87 11 during during IN cord-007445-2folsh35 87 12 the the DT cord-007445-2folsh35 87 13 RV16 RV16 NNP cord-007445-2folsh35 87 14 infection infection NN cord-007445-2folsh35 87 15 and and CC cord-007445-2folsh35 87 16 remained remain VBD cord-007445-2folsh35 87 17 elevated elevated JJ cord-007445-2folsh35 87 18 for for IN cord-007445-2folsh35 87 19 up up IN cord-007445-2folsh35 87 20 to to TO cord-007445-2folsh35 87 21 15 15 CD cord-007445-2folsh35 87 22 days day NNS cord-007445-2folsh35 87 23 after after IN cord-007445-2folsh35 87 24 the the DT cord-007445-2folsh35 87 25 acute acute JJ cord-007445-2folsh35 87 26 infection infection NN cord-007445-2folsh35 87 27 . . . cord-007445-2folsh35 88 1 This this DT cord-007445-2folsh35 88 2 study study NN cord-007445-2folsh35 88 3 indicates indicate VBZ cord-007445-2folsh35 88 4 that that IN cord-007445-2folsh35 88 5 an an DT cord-007445-2folsh35 88 6 upper upper JJ cord-007445-2folsh35 88 7 respiratory respiratory JJ cord-007445-2folsh35 88 8 viral viral JJ cord-007445-2folsh35 88 9 infection infection NN cord-007445-2folsh35 88 10 can can MD cord-007445-2folsh35 88 11 enhance enhance VB cord-007445-2folsh35 88 12 the the DT cord-007445-2folsh35 88 13 reactivity reactivity NN cord-007445-2folsh35 88 14 of of IN cord-007445-2folsh35 88 15 the the DT cord-007445-2folsh35 88 16 lower low JJR cord-007445-2folsh35 88 17 airway airway NN cord-007445-2folsh35 88 18 and and CC cord-007445-2folsh35 88 19 the the DT cord-007445-2folsh35 88 20 magnitude magnitude NN cord-007445-2folsh35 88 21 of of IN cord-007445-2folsh35 88 22 bronchonstriction bronchonstriction NN cord-007445-2folsh35 88 23 changes change NNS cord-007445-2folsh35 88 24 , , , cord-007445-2folsh35 88 25 which which WDT cord-007445-2folsh35 88 26 can can MD cord-007445-2folsh35 88 27 persist persist VB cord-007445-2folsh35 88 28 for for IN cord-007445-2folsh35 88 29 weeks week NNS cord-007445-2folsh35 88 30 after after IN cord-007445-2folsh35 88 31 the the DT cord-007445-2folsh35 88 32 acute acute JJ cord-007445-2folsh35 88 33 infection infection NN cord-007445-2folsh35 88 34 . . . cord-007445-2folsh35 89 1 Respiratory respiratory JJ cord-007445-2folsh35 89 2 viral viral JJ cord-007445-2folsh35 89 3 infections infection NNS cord-007445-2folsh35 89 4 ' ' POS cord-007445-2folsh35 89 5 effect effect NN cord-007445-2folsh35 89 6 on on IN cord-007445-2folsh35 89 7 lower low JJR cord-007445-2folsh35 89 8 airway airway NN cord-007445-2folsh35 89 9 responses response NNS cord-007445-2folsh35 89 10 are be VBP cord-007445-2folsh35 89 11 also also RB cord-007445-2folsh35 89 12 influenced influence VBN cord-007445-2folsh35 89 13 by by IN cord-007445-2folsh35 89 14 host host NN cord-007445-2folsh35 89 15 factors factor NNS cord-007445-2folsh35 89 16 . . . cord-007445-2folsh35 90 1 In in IN cord-007445-2folsh35 90 2 particular particular JJ cord-007445-2folsh35 90 3 , , , cord-007445-2folsh35 90 4 allergic allergic JJ cord-007445-2folsh35 90 5 subjects subject NNS cord-007445-2folsh35 90 6 experience experience VBP cord-007445-2folsh35 90 7 greater great JJR cord-007445-2folsh35 90 8 changes change NNS cord-007445-2folsh35 90 9 in in IN cord-007445-2folsh35 90 10 airway airway NN cord-007445-2folsh35 90 11 responsiveness responsiveness NN cord-007445-2folsh35 90 12 after after IN cord-007445-2folsh35 90 13 viral viral JJ cord-007445-2folsh35 90 14 infection infection NN cord-007445-2folsh35 90 15 than than IN cord-007445-2folsh35 90 16 nonallergic nonallergic NNP cord-007445-2folsh35 90 17 control control NNP cord-007445-2folsh35 90 18 s s NNP cord-007445-2folsh35 91 1 ~b ~b NNP cord-007445-2folsh35 91 2 j j NNP cord-007445-2folsh35 91 3 e e NN cord-007445-2folsh35 91 4 c c NNP cord-007445-2folsh35 91 5 t t NNP cord-007445-2folsh35 91 6 s s NNP cord-007445-2folsh35 91 7 .~ .~ NNP cord-007445-2folsh35 91 8 , , , cord-007445-2folsh35 91 9 34 34 CD cord-007445-2folsh35 92 1 Furthermore furthermore RB cord-007445-2folsh35 92 2 , , , cord-007445-2folsh35 92 3 subjects subject NNS cord-007445-2folsh35 92 4 with with IN cord-007445-2folsh35 92 5 lower low JJR cord-007445-2folsh35 92 6 FEV FEV NNP cord-007445-2folsh35 92 7 , , , cord-007445-2folsh35 92 8 values value NNS cord-007445-2folsh35 92 9 tend tend VBP cord-007445-2folsh35 92 10 to to TO cord-007445-2folsh35 92 11 have have VB cord-007445-2folsh35 92 12 greater great JJR cord-007445-2folsh35 92 13 changes change NNS cord-007445-2folsh35 92 14 in in IN cord-007445-2folsh35 92 15 airway airway NN cord-007445-2folsh35 92 16 responsiveness responsiveness NN cord-007445-2folsh35 92 17 during during IN cord-007445-2folsh35 92 18 viral viral JJ cord-007445-2folsh35 92 19 infecti0n.3~ infecti0n.3~ ADD cord-007445-2folsh35 93 1 These these DT cord-007445-2folsh35 93 2 studies study NNS cord-007445-2folsh35 93 3 suggest suggest VBP cord-007445-2folsh35 93 4 that that IN cord-007445-2folsh35 93 5 effects effect NNS cord-007445-2folsh35 93 6 of of IN cord-007445-2folsh35 93 7 pre pre JJ cord-007445-2folsh35 93 8 - - JJ cord-007445-2folsh35 93 9 existing existing JJ cord-007445-2folsh35 93 10 conditions condition NNS cord-007445-2folsh35 93 11 such such JJ cord-007445-2folsh35 93 12 as as IN cord-007445-2folsh35 93 13 allergy allergy NN cord-007445-2folsh35 93 14 and and CC cord-007445-2folsh35 93 15 intrinsic intrinsic JJ cord-007445-2folsh35 93 16 lower low JJR cord-007445-2folsh35 93 17 airway airway NN cord-007445-2folsh35 93 18 function function NN cord-007445-2folsh35 93 19 on on IN cord-007445-2folsh35 93 20 caliber caliber NN cord-007445-2folsh35 93 21 are be VBP cord-007445-2folsh35 93 22 likely likely JJ cord-007445-2folsh35 93 23 to to TO cord-007445-2folsh35 93 24 contribute contribute VB cord-007445-2folsh35 93 25 to to IN cord-007445-2folsh35 93 26 airway airway NN cord-007445-2folsh35 93 27 hyperresponsiveness hyperresponsiveness NN cord-007445-2folsh35 93 28 during during IN cord-007445-2folsh35 93 29 respiratory respiratory JJ cord-007445-2folsh35 93 30 viral viral JJ cord-007445-2folsh35 93 31 infection infection NN cord-007445-2folsh35 93 32 . . . cord-007445-2folsh35 94 1 Potential potential JJ cord-007445-2folsh35 94 2 mechanisms mechanism NNS cord-007445-2folsh35 94 3 through through IN cord-007445-2folsh35 94 4 which which WDT cord-007445-2folsh35 94 5 viral viral JJ cord-007445-2folsh35 94 6 infections infection NNS cord-007445-2folsh35 94 7 could could MD cord-007445-2folsh35 94 8 potentially potentially RB cord-007445-2folsh35 94 9 cause cause VB cord-007445-2folsh35 94 10 bronchoconstriction bronchoconstriction NN cord-007445-2folsh35 94 11 and and CC cord-007445-2folsh35 94 12 increased increase VBN cord-007445-2folsh35 94 13 airway airway NN cord-007445-2folsh35 94 14 responsiveness responsiveness NN cord-007445-2folsh35 94 15 include include VBP cord-007445-2folsh35 94 16 enhancing enhance VBG cord-007445-2folsh35 94 17 parasympathetic parasympathetic JJ cord-007445-2folsh35 94 18 bronchoconstrictive bronchoconstrictive JJ cord-007445-2folsh35 94 19 responses response NNS cord-007445-2folsh35 94 20 , , , cord-007445-2folsh35 94 21 stimulation stimulation NN cord-007445-2folsh35 94 22 of of IN cord-007445-2folsh35 94 23 airway airway JJ cord-007445-2folsh35 94 24 sensory sensory JJ cord-007445-2folsh35 94 25 nerves nerve NNS cord-007445-2folsh35 94 26 , , , cord-007445-2folsh35 94 27 and and CC cord-007445-2folsh35 94 28 interference interference NN cord-007445-2folsh35 94 29 with with IN cord-007445-2folsh35 94 30 the the DT cord-007445-2folsh35 94 31 bronchodilatory bronchodilatory JJ cord-007445-2folsh35 94 32 functions function NNS cord-007445-2folsh35 94 33 of of IN cord-007445-2folsh35 94 34 the the DT cord-007445-2folsh35 94 35 nonadrenergic nonadrenergic JJ cord-007445-2folsh35 94 36 , , , cord-007445-2folsh35 94 37 noncholinergic noncholinergic JJ cord-007445-2folsh35 94 38 neurons neuron NNS cord-007445-2folsh35 94 39 ( ( -LRB- cord-007445-2folsh35 94 40 Table table NN cord-007445-2folsh35 94 41 1 1 CD cord-007445-2folsh35 94 42 ) ) -RRB- cord-007445-2folsh35 94 43 . . . cord-007445-2folsh35 95 1 Because because IN cord-007445-2folsh35 95 2 of of IN cord-007445-2folsh35 95 3 difficulties difficulty NNS cord-007445-2folsh35 95 4 in in IN cord-007445-2folsh35 95 5 assessing assess VBG cord-007445-2folsh35 95 6 dysfunction dysfunction NN cord-007445-2folsh35 95 7 of of IN cord-007445-2folsh35 95 8 pulmonary pulmonary JJ cord-007445-2folsh35 95 9 neural neural JJ cord-007445-2folsh35 95 10 regulation regulation NN cord-007445-2folsh35 95 11 in in IN cord-007445-2folsh35 95 12 humans human NNS cord-007445-2folsh35 95 13 , , , cord-007445-2folsh35 95 14 most most JJS cord-007445-2folsh35 95 15 data datum NNS cord-007445-2folsh35 95 16 that that WDT cord-007445-2folsh35 95 17 support support VBP cord-007445-2folsh35 95 18 these these DT cord-007445-2folsh35 95 19 proposed propose VBN cord-007445-2folsh35 95 20 mechanisms mechanism NNS cord-007445-2folsh35 95 21 were be VBD cord-007445-2folsh35 95 22 derived derive VBN cord-007445-2folsh35 95 23 in in IN cord-007445-2folsh35 95 24 animal animal NN cord-007445-2folsh35 95 25 models model NNS cord-007445-2folsh35 95 26 of of IN cord-007445-2folsh35 95 27 acute acute JJ cord-007445-2folsh35 95 28 respiratory respiratory JJ cord-007445-2folsh35 95 29 viral viral JJ cord-007445-2folsh35 95 30 infection infection NN cord-007445-2folsh35 95 31 . . . cord-007445-2folsh35 96 1 Further further JJ cord-007445-2folsh35 96 2 definition definition NN cord-007445-2folsh35 96 3 of of IN cord-007445-2folsh35 96 4 these these DT cord-007445-2folsh35 96 5 pathways pathway NNS cord-007445-2folsh35 96 6 in in IN cord-007445-2folsh35 96 7 humans human NNS cord-007445-2folsh35 96 8 will will MD cord-007445-2folsh35 96 9 depend depend VB cord-007445-2folsh35 96 10 upon upon IN cord-007445-2folsh35 96 11 the the DT cord-007445-2folsh35 96 12 development development NN cord-007445-2folsh35 96 13 of of IN cord-007445-2folsh35 96 14 new new JJ cord-007445-2folsh35 96 15 experimental experimental JJ cord-007445-2folsh35 96 16 techniques technique NNS cord-007445-2folsh35 96 17 or or CC cord-007445-2folsh35 96 18 inhibition inhibition NN cord-007445-2folsh35 96 19 of of IN cord-007445-2folsh35 96 20 specific specific JJ cord-007445-2folsh35 96 21 neural neural JJ cord-007445-2folsh35 96 22 pathways pathway NNS cord-007445-2folsh35 96 23 . . . cord-007445-2folsh35 97 1 Increased increase VBN cord-007445-2folsh35 97 2 bronchial bronchial JJ cord-007445-2folsh35 97 3 responsiveness responsiveness NN cord-007445-2folsh35 97 4 has have VBZ cord-007445-2folsh35 97 5 been be VBN cord-007445-2folsh35 97 6 found find VBN cord-007445-2folsh35 97 7 in in IN cord-007445-2folsh35 97 8 normal normal JJ cord-007445-2folsh35 97 9 and and CC cord-007445-2folsh35 97 10 asthmatic asthmatic JJ cord-007445-2folsh35 97 11 subjects subject NNS cord-007445-2folsh35 97 12 Changes change NNS cord-007445-2folsh35 97 13 in in IN cord-007445-2folsh35 97 14 small small JJ cord-007445-2folsh35 97 15 airways airway NNS cord-007445-2folsh35 97 16 structure structure NN cord-007445-2folsh35 97 17 and and CC cord-007445-2folsh35 97 18 function function NN cord-007445-2folsh35 97 19 may may MD cord-007445-2folsh35 97 20 also also RB cord-007445-2folsh35 97 21 contribute contribute VB cord-007445-2folsh35 97 22 significantly significantly RB cord-007445-2folsh35 97 23 to to IN cord-007445-2folsh35 97 24 the the DT cord-007445-2folsh35 97 25 severity severity NN cord-007445-2folsh35 97 26 of of IN cord-007445-2folsh35 97 27 hyperinflation hyperinflation NN cord-007445-2folsh35 97 28 and and CC cord-007445-2folsh35 97 29 gas gas NN cord-007445-2folsh35 97 30 exchange exchange NN cord-007445-2folsh35 97 31 abnormalities abnormality NNS cord-007445-2folsh35 97 32 noted note VBN cord-007445-2folsh35 97 33 in in IN cord-007445-2folsh35 97 34 acute acute JJ cord-007445-2folsh35 97 35 asthma asthma NN cord-007445-2folsh35 97 36 exacerbations exacerbation NNS cord-007445-2folsh35 97 37 . . . cord-007445-2folsh35 98 1 The the DT cord-007445-2folsh35 98 2 maximal maximal JJ cord-007445-2folsh35 98 3 airway airway NN cord-007445-2folsh35 98 4 contractile contractile JJ cord-007445-2folsh35 98 5 response response NN cord-007445-2folsh35 98 6 to to TO cord-007445-2folsh35 98 7 methacholine methacholine NN cord-007445-2folsh35 98 8 in in IN cord-007445-2folsh35 98 9 mild mild JJ cord-007445-2folsh35 98 10 asthmatic asthmatic JJ cord-007445-2folsh35 98 11 subjects subject NNS cord-007445-2folsh35 98 12 is be VBZ cord-007445-2folsh35 98 13 increased increase VBN cord-007445-2folsh35 98 14 during during IN cord-007445-2folsh35 98 15 a a DT cord-007445-2folsh35 98 16 cold cold NN cord-007445-2folsh35 98 17 , , , cord-007445-2folsh35 98 18 which which WDT cord-007445-2folsh35 98 19 is be VBZ cord-007445-2folsh35 98 20 probably probably RB cord-007445-2folsh35 98 21 secondary secondary JJ cord-007445-2folsh35 98 22 to to IN cord-007445-2folsh35 98 23 excessive excessive JJ cord-007445-2folsh35 98 24 airway airway NN cord-007445-2folsh35 98 25 narrowing narrowing NN cord-007445-2folsh35 98 26 attributable attributable JJ cord-007445-2folsh35 98 27 to to IN cord-007445-2folsh35 98 28 airway airway NN cord-007445-2folsh35 98 29 wall wall NN cord-007445-2folsh35 98 30 thickening thickening NN cord-007445-2folsh35 98 31 , , , cord-007445-2folsh35 98 32 airway airway NN cord-007445-2folsh35 98 33 parenchymal parenchymal NN cord-007445-2folsh35 98 34 uncoupling uncoupling NN cord-007445-2folsh35 98 35 , , , cord-007445-2folsh35 98 36 or or CC cord-007445-2folsh35 98 37 abnormalities abnormality NNS cord-007445-2folsh35 98 38 in in IN cord-007445-2folsh35 98 39 smooth smooth JJ cord-007445-2folsh35 98 40 muscle muscle NN cord-007445-2folsh35 98 41 ~0ntraction.l~ ~0ntraction.l~ . cord-007445-2folsh35 98 42 Significant significant JJ cord-007445-2folsh35 98 43 changes change NNS cord-007445-2folsh35 98 44 in in IN cord-007445-2folsh35 98 45 airway airway NN cord-007445-2folsh35 98 46 morphology morphology NN cord-007445-2folsh35 98 47 are be VBP cord-007445-2folsh35 98 48 noticed notice VBN cord-007445-2folsh35 98 49 in in IN cord-007445-2folsh35 98 50 animals animal NNS cord-007445-2folsh35 98 51 with with IN cord-007445-2folsh35 98 52 acute acute JJ cord-007445-2folsh35 98 53 viral viral JJ cord-007445-2folsh35 98 54 respiratory respiratory JJ cord-007445-2folsh35 98 55 illness illness NN cord-007445-2folsh35 98 56 that that WDT cord-007445-2folsh35 98 57 leads lead VBZ cord-007445-2folsh35 98 58 to to IN cord-007445-2folsh35 98 59 marked mark VBN cord-007445-2folsh35 98 60 bronchiolar bronchiolar JJ cord-007445-2folsh35 98 61 narrowing narrowing NN cord-007445-2folsh35 98 62 and and CC cord-007445-2folsh35 98 63 plugging plugging NN cord-007445-2folsh35 98 64 . . . cord-007445-2folsh35 99 1 These these DT cord-007445-2folsh35 99 2 changes change NNS cord-007445-2folsh35 99 3 include include VBP cord-007445-2folsh35 99 4 bronchiolar bronchiolar JJ cord-007445-2folsh35 99 5 airway airway NN cord-007445-2folsh35 99 6 edema edema NN cord-007445-2folsh35 99 7 and and CC cord-007445-2folsh35 99 8 cell cell NN cord-007445-2folsh35 99 9 infiltration infiltration NN cord-007445-2folsh35 99 10 , , , cord-007445-2folsh35 99 11 epithelial epithelial JJ cord-007445-2folsh35 99 12 hyperplasia hyperplasia NN cord-007445-2folsh35 99 13 , , , cord-007445-2folsh35 99 14 and and CC cord-007445-2folsh35 99 15 folding folding NN cord-007445-2folsh35 99 16 and and CC cord-007445-2folsh35 99 17 sloughing sloughing NN cord-007445-2folsh35 99 18 of of IN cord-007445-2folsh35 99 19 airway airway JJ cord-007445-2folsh35 99 20 epithelial epithelial JJ cord-007445-2folsh35 99 21 surfaces surface NNS cord-007445-2folsh35 99 22 . . . cord-007445-2folsh35 100 1 In in IN cord-007445-2folsh35 100 2 addition addition NN cord-007445-2folsh35 100 3 , , , cord-007445-2folsh35 100 4 rats rat NNS cord-007445-2folsh35 100 5 with with IN cord-007445-2folsh35 100 6 mild mild JJ cord-007445-2folsh35 100 7 increases increase NNS cord-007445-2folsh35 100 8 in in IN cord-007445-2folsh35 100 9 pulmonary pulmonary JJ cord-007445-2folsh35 100 10 resistance resistance NN cord-007445-2folsh35 100 11 and and CC cord-007445-2folsh35 100 12 methacholine methacholine NN cord-007445-2folsh35 100 13 sensitivity sensitivity NN cord-007445-2folsh35 100 14 during during IN cord-007445-2folsh35 100 15 acute acute JJ cord-007445-2folsh35 100 16 viral viral JJ cord-007445-2folsh35 100 17 respiratory respiratory JJ cord-007445-2folsh35 100 18 illness illness NN cord-007445-2folsh35 100 19 have have VBP cord-007445-2folsh35 100 20 evidence evidence NN cord-007445-2folsh35 100 21 of of IN cord-007445-2folsh35 100 22 air air NN cord-007445-2folsh35 100 23 trapping trapping NN cord-007445-2folsh35 100 24 and and CC cord-007445-2folsh35 100 25 ventilationperfusion ventilationperfusion NN cord-007445-2folsh35 101 1 mismatches.101 mismatches.101 NNP cord-007445-2folsh35 102 1 These these DT cord-007445-2folsh35 102 2 latter latter JJ cord-007445-2folsh35 102 3 findings finding NNS cord-007445-2folsh35 102 4 indicate indicate VBP cord-007445-2folsh35 102 5 that that IN cord-007445-2folsh35 102 6 viruses virus NNS cord-007445-2folsh35 102 7 can can MD cord-007445-2folsh35 102 8 induce induce VB cord-007445-2folsh35 102 9 significant significant JJ cord-007445-2folsh35 102 10 changes change NNS cord-007445-2folsh35 102 11 in in IN cord-007445-2folsh35 102 12 the the DT cord-007445-2folsh35 102 13 peripheral peripheral JJ cord-007445-2folsh35 102 14 airways airway NNS cord-007445-2folsh35 102 15 that that WDT cord-007445-2folsh35 102 16 have have VBP cord-007445-2folsh35 102 17 significant significant JJ cord-007445-2folsh35 102 18 functional functional JJ cord-007445-2folsh35 102 19 outcomes outcome NNS cord-007445-2folsh35 102 20 in in IN cord-007445-2folsh35 102 21 the the DT cord-007445-2folsh35 102 22 absence absence NN cord-007445-2folsh35 102 23 of of IN cord-007445-2folsh35 102 24 marked marked JJ cord-007445-2folsh35 102 25 changes change NNS cord-007445-2folsh35 102 26 in in IN cord-007445-2folsh35 102 27 measurements measurement NNS cord-007445-2folsh35 102 28 of of IN cord-007445-2folsh35 102 29 airway airway NN cord-007445-2folsh35 102 30 obstruction obstruction NN cord-007445-2folsh35 102 31 and and CC cord-007445-2folsh35 102 32 hyperresponsiveness hyperresponsiveness NN cord-007445-2folsh35 102 33 . . . cord-007445-2folsh35 103 1 Respiratory respiratory JJ cord-007445-2folsh35 103 2 viruses virus NNS cord-007445-2folsh35 103 3 can can MD cord-007445-2folsh35 103 4 cause cause VB cord-007445-2folsh35 103 5 inflammation inflammation NN cord-007445-2folsh35 103 6 and and CC cord-007445-2folsh35 103 7 injury injury NN cord-007445-2folsh35 103 8 to to IN cord-007445-2folsh35 103 9 healthy healthy NNP cord-007445-2folsh35 103 10 airways airway NNS cord-007445-2folsh35 103 11 and and CC cord-007445-2folsh35 103 12 can can MD cord-007445-2folsh35 103 13 worsen worsen VB cord-007445-2folsh35 103 14 injury injury NN cord-007445-2folsh35 103 15 in in IN cord-007445-2folsh35 103 16 airways airway NNS cord-007445-2folsh35 103 17 that that WDT cord-007445-2folsh35 103 18 are be VBP cord-007445-2folsh35 103 19 already already RB cord-007445-2folsh35 103 20 inflamed inflame VBN cord-007445-2folsh35 103 21 , , , cord-007445-2folsh35 103 22 as as IN cord-007445-2folsh35 103 23 demonstrable demonstrable JJ cord-007445-2folsh35 103 24 in in IN cord-007445-2folsh35 103 25 asthma asthma NN cord-007445-2folsh35 103 26 . . . cord-007445-2folsh35 104 1 Respiratory respiratory JJ cord-007445-2folsh35 104 2 viruses virus NNS cord-007445-2folsh35 104 3 can can MD cord-007445-2folsh35 104 4 induce induce VB cord-007445-2folsh35 104 5 an an DT cord-007445-2folsh35 104 6 inflammatory inflammatory JJ cord-007445-2folsh35 104 7 process process NN cord-007445-2folsh35 104 8 by by IN cord-007445-2folsh35 104 9 direct direct JJ cord-007445-2folsh35 104 10 cytopathic cytopathic JJ cord-007445-2folsh35 104 11 effects effect NNS cord-007445-2folsh35 104 12 on on IN cord-007445-2folsh35 104 13 the the DT cord-007445-2folsh35 104 14 airway airway NN cord-007445-2folsh35 104 15 epithelium epithelium NN cord-007445-2folsh35 104 16 ( ( -LRB- cord-007445-2folsh35 104 17 e.g. e.g. RB cord-007445-2folsh35 104 18 , , , cord-007445-2folsh35 104 19 RSV RSV NNP cord-007445-2folsh35 104 20 bronchiolitis bronchiolitis NNP cord-007445-2folsh35 104 21 ) ) -RRB- cord-007445-2folsh35 104 22 and and CC cord-007445-2folsh35 104 23 can can MD cord-007445-2folsh35 104 24 induce induce VB cord-007445-2folsh35 104 25 an an DT cord-007445-2folsh35 104 26 immune immune JJ cord-007445-2folsh35 104 27 response response NN cord-007445-2folsh35 104 28 to to TO cord-007445-2folsh35 104 29 stop stop VB cord-007445-2folsh35 104 30 viral viral JJ cord-007445-2folsh35 104 31 replication replication NN cord-007445-2folsh35 104 32 and and CC cord-007445-2folsh35 104 33 eradicate eradicate VB cord-007445-2folsh35 104 34 the the DT cord-007445-2folsh35 104 35 virus virus NN cord-007445-2folsh35 104 36 . . . cord-007445-2folsh35 105 1 The the DT cord-007445-2folsh35 105 2 immune immune JJ cord-007445-2folsh35 105 3 re re NN cord-007445-2folsh35 105 4 - - NN cord-007445-2folsh35 105 5 sponse sponse JJ cord-007445-2folsh35 105 6 to to IN cord-007445-2folsh35 105 7 viral viral JJ cord-007445-2folsh35 105 8 infection infection NN cord-007445-2folsh35 105 9 may may MD cord-007445-2folsh35 105 10 be be VB cord-007445-2folsh35 105 11 a a DT cord-007445-2folsh35 105 12 doubleedged doubleedged JJ cord-007445-2folsh35 105 13 sword sword NN cord-007445-2folsh35 105 14 , , , cord-007445-2folsh35 105 15 however however RB cord-007445-2folsh35 105 16 , , , cord-007445-2folsh35 105 17 as as IN cord-007445-2folsh35 105 18 virus virus NN cord-007445-2folsh35 105 19 - - HYPH cord-007445-2folsh35 105 20 induced induce VBN cord-007445-2folsh35 105 21 inflammation inflammation NN cord-007445-2folsh35 105 22 can can MD cord-007445-2folsh35 105 23 also also RB cord-007445-2folsh35 105 24 contribute contribute VB cord-007445-2folsh35 105 25 to to IN cord-007445-2folsh35 105 26 airway airway JJ cord-007445-2folsh35 105 27 obstruction obstruction NN cord-007445-2folsh35 105 28 and and CC cord-007445-2folsh35 105 29 respiratory respiratory JJ cord-007445-2folsh35 105 30 symptoms symptom NNS cord-007445-2folsh35 105 31 . . . cord-007445-2folsh35 106 1 Indeed indeed RB cord-007445-2folsh35 106 2 , , , cord-007445-2folsh35 106 3 although although IN cord-007445-2folsh35 106 4 many many JJ cord-007445-2folsh35 106 5 common common JJ cord-007445-2folsh35 106 6 cold cold JJ cord-007445-2folsh35 106 7 viruses virus NNS cord-007445-2folsh35 106 8 ( ( -LRB- cord-007445-2folsh35 106 9 e.g. e.g. RB cord-007445-2folsh35 106 10 , , , cord-007445-2folsh35 106 11 RV RV NNP cord-007445-2folsh35 106 12 ) ) -RRB- cord-007445-2folsh35 106 13 do do VBP cord-007445-2folsh35 106 14 not not RB cord-007445-2folsh35 106 15 produce produce VB cord-007445-2folsh35 106 16 significant significant JJ cord-007445-2folsh35 106 17 cytopathic cytopathic JJ cord-007445-2folsh35 106 18 effects effect NNS cord-007445-2folsh35 106 19 , , , cord-007445-2folsh35 106 20 possibly possibly RB cord-007445-2folsh35 106 21 because because IN cord-007445-2folsh35 106 22 few few JJ cord-007445-2folsh35 106 23 cells cell NNS cord-007445-2folsh35 106 24 are be VBP cord-007445-2folsh35 106 25 infected infect VBN cord-007445-2folsh35 106 26 , , , cord-007445-2folsh35 106 27 the the DT cord-007445-2folsh35 106 28 immunoinflammatory immunoinflammatory NNP cord-007445-2folsh35 106 29 response response NN cord-007445-2folsh35 106 30 to to IN cord-007445-2folsh35 106 31 the the DT cord-007445-2folsh35 106 32 virus virus NN cord-007445-2folsh35 106 33 is be VBZ cord-007445-2folsh35 106 34 probably probably RB cord-007445-2folsh35 106 35 the the DT cord-007445-2folsh35 106 36 major major JJ cord-007445-2folsh35 106 37 cause cause NN cord-007445-2folsh35 106 38 of of IN cord-007445-2folsh35 106 39 respiratory respiratory JJ cord-007445-2folsh35 106 40 symptoms symptom NNS cord-007445-2folsh35 106 41 . . . cord-007445-2folsh35 107 1 In in IN cord-007445-2folsh35 107 2 this this DT cord-007445-2folsh35 107 3 section section NN cord-007445-2folsh35 107 4 , , , cord-007445-2folsh35 107 5 the the DT cord-007445-2folsh35 107 6 association association NN cord-007445-2folsh35 107 7 between between IN cord-007445-2folsh35 107 8 virus virus NN cord-007445-2folsh35 107 9 - - HYPH cord-007445-2folsh35 107 10 induced induce VBN cord-007445-2folsh35 107 11 immune immune JJ cord-007445-2folsh35 107 12 responses response NNS cord-007445-2folsh35 107 13 and and CC cord-007445-2folsh35 107 14 respiratory respiratory JJ cord-007445-2folsh35 107 15 symptoms symptom NNS cord-007445-2folsh35 107 16 is be VBZ cord-007445-2folsh35 107 17 explored explore VBN cord-007445-2folsh35 107 18 . . . cord-007445-2folsh35 108 1 Respiratory respiratory JJ cord-007445-2folsh35 108 2 viruses virus NNS cord-007445-2folsh35 108 3 replicate replicate VBP cord-007445-2folsh35 108 4 primarily primarily RB cord-007445-2folsh35 108 5 in in IN cord-007445-2folsh35 108 6 airway airway JJ cord-007445-2folsh35 108 7 epithelial epithelial JJ cord-007445-2folsh35 108 8 cells cell NNS cord-007445-2folsh35 108 9 . . . cord-007445-2folsh35 109 1 In in IN cord-007445-2folsh35 109 2 addition addition NN cord-007445-2folsh35 109 3 to to IN cord-007445-2folsh35 109 4 serving serve VBG cord-007445-2folsh35 109 5 as as IN cord-007445-2folsh35 109 6 host host NN cord-007445-2folsh35 109 7 cells cell NNS cord-007445-2folsh35 109 8 , , , cord-007445-2folsh35 109 9 it -PRON- PRP cord-007445-2folsh35 109 10 is be VBZ cord-007445-2folsh35 109 11 now now RB cord-007445-2folsh35 109 12 well well RB cord-007445-2folsh35 109 13 documented document VBN cord-007445-2folsh35 109 14 that that IN cord-007445-2folsh35 109 15 epithelial epithelial JJ cord-007445-2folsh35 109 16 cells cell NNS cord-007445-2folsh35 109 17 also also RB cord-007445-2folsh35 109 18 initiate initiate VBP cord-007445-2folsh35 109 19 the the DT cord-007445-2folsh35 109 20 immune immune JJ cord-007445-2folsh35 109 21 response response NN cord-007445-2folsh35 109 22 to to IN cord-007445-2folsh35 109 23 infections infection NNS cord-007445-2folsh35 109 24 through through IN cord-007445-2folsh35 109 25 the the DT cord-007445-2folsh35 109 26 secretion secretion NN cord-007445-2folsh35 109 27 of of IN cord-007445-2folsh35 109 28 cytokines cytokine NNS cord-007445-2folsh35 109 29 and and CC cord-007445-2folsh35 109 30 chemokines chemokine NNS cord-007445-2folsh35 109 31 . . . cord-007445-2folsh35 110 1 In in IN cord-007445-2folsh35 110 2 vitro vitro FW cord-007445-2folsh35 110 3 studies study NNS cord-007445-2folsh35 110 4 of of IN cord-007445-2folsh35 110 5 epithelial epithelial JJ cord-007445-2folsh35 110 6 cells cell NNS cord-007445-2folsh35 110 7 or or CC cord-007445-2folsh35 110 8 cell cell NN cord-007445-2folsh35 110 9 lines line NNS cord-007445-2folsh35 110 10 have have VBP cord-007445-2folsh35 110 11 demonstrated demonstrate VBN cord-007445-2folsh35 110 12 that that IN cord-007445-2folsh35 110 13 respiratory respiratory JJ cord-007445-2folsh35 110 14 viruses virus NNS cord-007445-2folsh35 110 15 such such JJ cord-007445-2folsh35 110 16 as as IN cord-007445-2folsh35 110 17 RV RV NNP cord-007445-2folsh35 110 18 , , , cord-007445-2folsh35 110 19 RSV RSV NNP cord-007445-2folsh35 110 20 , , , cord-007445-2folsh35 110 21 and and CC cord-007445-2folsh35 110 22 parainfluenzavirus parainfluenzavirus NNP cord-007445-2folsh35 110 23 can can MD cord-007445-2folsh35 110 24 induce induce VB cord-007445-2folsh35 110 25 the the DT cord-007445-2folsh35 110 26 secretion secretion NN cord-007445-2folsh35 110 27 of of IN cord-007445-2folsh35 110 28 many many JJ cord-007445-2folsh35 110 29 different different JJ cord-007445-2folsh35 110 30 proinflammatory proinflammatory JJ cord-007445-2folsh35 110 31 cytokines cytokine NNS cord-007445-2folsh35 110 32 ( ( -LRB- cord-007445-2folsh35 110 33 IL-1 IL-1 NNP cord-007445-2folsh35 110 34 , , , cord-007445-2folsh35 110 35 TNF TNF NNP cord-007445-2folsh35 110 36 - - HYPH cord-007445-2folsh35 110 37 a a NNP cord-007445-2folsh35 110 38 , , , cord-007445-2folsh35 110 39 GM GM NNP cord-007445-2folsh35 110 40 - - HYPH cord-007445-2folsh35 110 41 CSF CSF NNP cord-007445-2folsh35 110 42 , , , cord-007445-2folsh35 110 43 IL-6 IL-6 NNP cord-007445-2folsh35 110 44 , , , cord-007445-2folsh35 110 45 IL-11 IL-11 NNP cord-007445-2folsh35 110 46 ) ) -RRB- cord-007445-2folsh35 110 47 and and CC cord-007445-2folsh35 110 48 chemokines chemokine NNS cord-007445-2folsh35 110 49 ( ( -LRB- cord-007445-2folsh35 110 50 RANTES RANTES NNPS cord-007445-2folsh35 110 51 , , , cord-007445-2folsh35 110 52 IL-8 IL-8 NNP cord-007445-2folsh35 110 53 , , , cord-007445-2folsh35 110 54 MIP MIP NNP cord-007445-2folsh35 110 55 - - HYPH cord-007445-2folsh35 110 56 la).lo la).lo NNS cord-007445-2folsh35 110 57 , , , cord-007445-2folsh35 110 58 20 20 CD cord-007445-2folsh35 110 59 , , , cord-007445-2folsh35 110 60 23 23 CD cord-007445-2folsh35 110 61 , , , cord-007445-2folsh35 110 62 96 96 CD cord-007445-2folsh35 110 63 , , , cord-007445-2folsh35 110 64 98 98 CD cord-007445-2folsh35 110 65 , , , cord-007445-2folsh35 110 66 lo5 lo5 NNP cord-007445-2folsh35 110 67 Epithelial epithelial NN cord-007445-2folsh35 110 68 - - HYPH cord-007445-2folsh35 110 69 derived derive VBN cord-007445-2folsh35 110 70 chemokines chemokine NNS cord-007445-2folsh35 110 71 are be VBP cord-007445-2folsh35 110 72 likely likely JJ cord-007445-2folsh35 110 73 to to TO cord-007445-2folsh35 110 74 be be VB cord-007445-2folsh35 110 75 an an DT cord-007445-2folsh35 110 76 important important JJ cord-007445-2folsh35 110 77 signal signal NN cord-007445-2folsh35 110 78 in in IN cord-007445-2folsh35 110 79 initiating initiate VBG cord-007445-2folsh35 110 80 antiviral antiviral JJ cord-007445-2folsh35 110 81 responses response NNS cord-007445-2folsh35 110 82 through through IN cord-007445-2folsh35 110 83 the the DT cord-007445-2folsh35 110 84 recruitment recruitment NN cord-007445-2folsh35 110 85 of of IN cord-007445-2folsh35 110 86 leukocytes leukocyte NNS cord-007445-2folsh35 110 87 to to IN cord-007445-2folsh35 110 88 the the DT cord-007445-2folsh35 110 89 airway airway NN cord-007445-2folsh35 110 90 . . . cord-007445-2folsh35 111 1 In in IN cord-007445-2folsh35 111 2 support support NN cord-007445-2folsh35 111 3 of of IN cord-007445-2folsh35 111 4 this this DT cord-007445-2folsh35 111 5 concept concept NN cord-007445-2folsh35 111 6 , , , cord-007445-2folsh35 111 7 IL-8 IL-8 NNP cord-007445-2folsh35 111 8 , , , cord-007445-2folsh35 111 9 a a DT cord-007445-2folsh35 111 10 potent potent JJ cord-007445-2folsh35 111 11 neutrophil neutrophil NN cord-007445-2folsh35 111 12 chemoattractant chemoattractant NN cord-007445-2folsh35 111 13 , , , cord-007445-2folsh35 111 14 is be VBZ cord-007445-2folsh35 111 15 found find VBN cord-007445-2folsh35 111 16 in in IN cord-007445-2folsh35 111 17 high high JJ cord-007445-2folsh35 111 18 levels level NNS cord-007445-2folsh35 111 19 in in IN cord-007445-2folsh35 111 20 nasal nasal JJ cord-007445-2folsh35 111 21 secretions secretion NNS cord-007445-2folsh35 111 22 of of IN cord-007445-2folsh35 111 23 children child NNS cord-007445-2folsh35 111 24 with with IN cord-007445-2folsh35 111 25 virus virus NN cord-007445-2folsh35 111 26 - - HYPH cord-007445-2folsh35 111 27 induced induce VBN cord-007445-2folsh35 111 28 asthma asthma NN cord-007445-2folsh35 111 29 , , , cord-007445-2folsh35 111 30 and and CC cord-007445-2folsh35 111 31 levels level NNS cord-007445-2folsh35 111 32 of of IN cord-007445-2folsh35 111 33 IL-8 IL-8 NNP cord-007445-2folsh35 111 34 correlate correlate VBP cord-007445-2folsh35 111 35 with with IN cord-007445-2folsh35 111 36 the the DT cord-007445-2folsh35 111 37 number number NN cord-007445-2folsh35 111 38 of of IN cord-007445-2folsh35 111 39 airway airway NN cord-007445-2folsh35 111 40 neutrophils neutrophil NNS cord-007445-2folsh35 111 41 and and CC cord-007445-2folsh35 111 42 neutrophil neutrophil NN cord-007445-2folsh35 111 43 myeloperoxidase myeloperoxidase NN cord-007445-2folsh35 111 44 levels level NNS cord-007445-2folsh35 111 45 ( ( -LRB- cord-007445-2folsh35 111 46 suggesting suggest VBG cord-007445-2folsh35 111 47 neutrophil neutrophil NN cord-007445-2folsh35 111 48 activation).lo8 activation).lo8 . cord-007445-2folsh35 112 1 There there EX cord-007445-2folsh35 112 2 is be VBZ cord-007445-2folsh35 112 3 also also RB cord-007445-2folsh35 112 4 evidence evidence NN cord-007445-2folsh35 112 5 , , , cord-007445-2folsh35 112 6 however however RB cord-007445-2folsh35 112 7 , , , cord-007445-2folsh35 112 8 that that DT cord-007445-2folsh35 112 9 enhanced enhance VBN cord-007445-2folsh35 112 10 airway airway NN cord-007445-2folsh35 112 11 inflammation inflammation NN cord-007445-2folsh35 112 12 caused cause VBN cord-007445-2folsh35 112 13 by by IN cord-007445-2folsh35 112 14 chemokine chemokine NN cord-007445-2folsh35 112 15 secretion secretion NN cord-007445-2folsh35 112 16 may may MD cord-007445-2folsh35 112 17 also also RB cord-007445-2folsh35 112 18 disturb disturb VB cord-007445-2folsh35 112 19 normal normal JJ cord-007445-2folsh35 112 20 air air NN cord-007445-2folsh35 112 21 - - HYPH cord-007445-2folsh35 112 22 way way NN cord-007445-2folsh35 112 23 physiology physiology NN cord-007445-2folsh35 112 24 . . . cord-007445-2folsh35 113 1 Chemokine chemokine JJ cord-007445-2folsh35 113 2 levels level NNS cord-007445-2folsh35 113 3 in in IN cord-007445-2folsh35 113 4 nasal nasal NN cord-007445-2folsh35 113 5 secretions secretion NNS cord-007445-2folsh35 113 6 correlate correlate VBP cord-007445-2folsh35 113 7 closely closely RB cord-007445-2folsh35 113 8 with with IN cord-007445-2folsh35 113 9 cold cold NN cord-007445-2folsh35 113 10 symptoms,"O symptoms,"o JJ cord-007445-2folsh35 113 11 for for IN cord-007445-2folsh35 113 12 example example NN cord-007445-2folsh35 113 13 , , , cord-007445-2folsh35 113 14 and and CC cord-007445-2folsh35 113 15 IL-8 il-8 NN cord-007445-2folsh35 113 16 levels level NNS cord-007445-2folsh35 113 17 correlate correlate VBP cord-007445-2folsh35 113 18 with with IN cord-007445-2folsh35 113 19 virus virus NN cord-007445-2folsh35 113 20 - - HYPH cord-007445-2folsh35 113 21 induced induce VBN cord-007445-2folsh35 113 22 changes change NNS cord-007445-2folsh35 113 23 in in IN cord-007445-2folsh35 113 24 airway airway NN cord-007445-2folsh35 113 25 respon-~i respon-~i NNP cord-007445-2folsh35 113 26 v v NN cord-007445-2folsh35 113 27 e e NN cord-007445-2folsh35 113 28 n n NN cord-007445-2folsh35 113 29 e e NNP cord-007445-2folsh35 113 30 s s NN cord-007445-2folsh35 113 31 s s NN cord-007445-2folsh35 113 32 .~~ .~~ . cord-007445-2folsh35 114 1 Levels level NNS cord-007445-2folsh35 114 2 of of IN cord-007445-2folsh35 114 3 epithelial epithelial NN cord-007445-2folsh35 114 4 - - HYPH cord-007445-2folsh35 114 5 derived derive VBN cord-007445-2folsh35 114 6 cytokines cytokine NNS cord-007445-2folsh35 114 7 such such JJ cord-007445-2folsh35 114 8 as as IN cord-007445-2folsh35 114 9 IL-6 IL-6 NNP cord-007445-2folsh35 114 10 and and CC cord-007445-2folsh35 114 11 IL-11 IL-11 NNP cord-007445-2folsh35 114 12 also also RB cord-007445-2folsh35 114 13 correlate correlate VBP cord-007445-2folsh35 114 14 with with IN cord-007445-2folsh35 114 15 respiratory respiratory JJ cord-007445-2folsh35 114 16 syrnpt0ms,2~ syrnpt0ms,2~ NN cord-007445-2folsh35 114 17 and and CC cord-007445-2folsh35 114 18 animal animal NN cord-007445-2folsh35 114 19 studies study NNS cord-007445-2folsh35 114 20 indicate indicate VBP cord-007445-2folsh35 114 21 that that IN cord-007445-2folsh35 114 22 overexpression overexpression NN cord-007445-2folsh35 114 23 of of IN cord-007445-2folsh35 114 24 IL-11 IL-11 NNP cord-007445-2folsh35 114 25 can can MD cord-007445-2folsh35 114 26 cause cause VB cord-007445-2folsh35 114 27 bronchial bronchial JJ cord-007445-2folsh35 114 28 hyperresponsi hyperresponsi NNP cord-007445-2folsh35 114 29 ~ ~ NFP cord-007445-2folsh35 114 30 eness.~~~ eness.~~~ NNP cord-007445-2folsh35 114 31 Io7 io7 NN cord-007445-2folsh35 115 1 In in IN cord-007445-2folsh35 115 2 addition addition NN cord-007445-2folsh35 115 3 to to IN cord-007445-2folsh35 115 4 stimulating stimulate VBG cord-007445-2folsh35 115 5 cytokine cytokine NN cord-007445-2folsh35 115 6 production production NN cord-007445-2folsh35 115 7 , , , cord-007445-2folsh35 115 8 RV RV NNP cord-007445-2folsh35 115 9 can can MD cord-007445-2folsh35 115 10 upregulate upregulate VB cord-007445-2folsh35 115 11 epithelial epithelial JJ cord-007445-2folsh35 115 12 cell cell NN cord-007445-2folsh35 115 13 surface surface NN cord-007445-2folsh35 115 14 expression expression NN cord-007445-2folsh35 115 15 of of IN cord-007445-2folsh35 115 16 intercellular intercellular JJ cord-007445-2folsh35 115 17 adhesion adhesion NN cord-007445-2folsh35 115 18 molecule-1,79 molecule-1,79 CD cord-007445-2folsh35 115 19 which which WDT cord-007445-2folsh35 115 20 , , , cord-007445-2folsh35 115 21 in in IN cord-007445-2folsh35 115 22 addition addition NN cord-007445-2folsh35 115 23 to to IN cord-007445-2folsh35 115 24 facilitating facilitate VBG cord-007445-2folsh35 115 25 cell cell NN cord-007445-2folsh35 115 26 - - HYPH cord-007445-2folsh35 115 27 cell cell NN cord-007445-2folsh35 115 28 adhesion adhesion NN cord-007445-2folsh35 115 29 , , , cord-007445-2folsh35 115 30 is be VBZ cord-007445-2folsh35 115 31 the the DT cord-007445-2folsh35 115 32 receptor receptor NN cord-007445-2folsh35 115 33 for for IN cord-007445-2folsh35 115 34 the the DT cord-007445-2folsh35 115 35 major major JJ cord-007445-2folsh35 115 36 group group NN cord-007445-2folsh35 115 37 of of IN cord-007445-2folsh35 115 38 RV3 RV3 NNP cord-007445-2folsh35 115 39 " " `` cord-007445-2folsh35 115 40 lo3 lo3 JJ cord-007445-2folsh35 116 1 This this DT cord-007445-2folsh35 116 2 enhanced enhanced JJ cord-007445-2folsh35 116 3 expression expression NN cord-007445-2folsh35 116 4 of of IN cord-007445-2folsh35 116 5 adhesion adhesion NN cord-007445-2folsh35 116 6 proteins protein NNS cord-007445-2folsh35 116 7 may may MD cord-007445-2folsh35 116 8 contribute contribute VB cord-007445-2folsh35 116 9 to to IN cord-007445-2folsh35 116 10 the the DT cord-007445-2folsh35 116 11 persistence persistence NN cord-007445-2folsh35 116 12 and and CC cord-007445-2folsh35 116 13 severity severity NN cord-007445-2folsh35 116 14 of of IN cord-007445-2folsh35 116 15 inflammation inflammation NN cord-007445-2folsh35 116 16 in in IN cord-007445-2folsh35 116 17 asthmatic asthmatic JJ cord-007445-2folsh35 116 18 subjects subject NNS cord-007445-2folsh35 116 19 and and CC cord-007445-2folsh35 116 20 , , , cord-007445-2folsh35 116 21 possibly possibly RB cord-007445-2folsh35 116 22 , , , cord-007445-2folsh35 116 23 the the DT cord-007445-2folsh35 116 24 greater great JJR cord-007445-2folsh35 116 25 susceptibility susceptibility NN cord-007445-2folsh35 116 26 of of IN cord-007445-2folsh35 116 27 asthmatic asthmatic JJ cord-007445-2folsh35 116 28 children child NNS cord-007445-2folsh35 116 29 to to IN cord-007445-2folsh35 116 30 colds cold NNS cord-007445-2folsh35 116 31 compared compare VBN cord-007445-2folsh35 116 32 with with IN cord-007445-2folsh35 116 33 nonasthmatic nonasthmatic JJ cord-007445-2folsh35 116 34 children child NNS cord-007445-2folsh35 116 35 . . . cord-007445-2folsh35 117 1 Mechanisms mechanism NNS cord-007445-2folsh35 117 2 for for IN cord-007445-2folsh35 117 3 the the DT cord-007445-2folsh35 117 4 activation activation NN cord-007445-2folsh35 117 5 of of IN cord-007445-2folsh35 117 6 cytokine cytokine JJ cord-007445-2folsh35 117 7 genes gene NNS cord-007445-2folsh35 117 8 in in IN cord-007445-2folsh35 117 9 epithelial epithelial JJ cord-007445-2folsh35 117 10 cells cell NNS cord-007445-2folsh35 117 11 and and CC cord-007445-2folsh35 117 12 adhesion adhesion NN cord-007445-2folsh35 117 13 molecules molecule NNS cord-007445-2folsh35 117 14 are be VBP cord-007445-2folsh35 117 15 under under IN cord-007445-2folsh35 117 16 investigation investigation NN cord-007445-2folsh35 117 17 . . . cord-007445-2folsh35 118 1 It -PRON- PRP cord-007445-2folsh35 118 2 is be VBZ cord-007445-2folsh35 118 3 known know VBN cord-007445-2folsh35 118 4 that that IN cord-007445-2folsh35 118 5 nuclear nuclear JJ cord-007445-2folsh35 118 6 factor factor NN cord-007445-2folsh35 118 7 - - HYPH cord-007445-2folsh35 118 8 lc lc NNP cord-007445-2folsh35 118 9 B B NNP cord-007445-2folsh35 118 10 activation activation NN cord-007445-2folsh35 118 11 is be VBZ cord-007445-2folsh35 118 12 important important JJ cord-007445-2folsh35 118 13 in in IN cord-007445-2folsh35 118 14 virus virus NN cord-007445-2folsh35 118 15 - - HYPH cord-007445-2folsh35 118 16 induced induce VBN cord-007445-2folsh35 118 17 transcriptional transcriptional JJ cord-007445-2folsh35 118 18 regulation regulation NN cord-007445-2folsh35 118 19 of of IN cord-007445-2folsh35 118 20 IL-650 il-650 NN cord-007445-2folsh35 118 21 and and CC cord-007445-2folsh35 118 22 , , , cord-007445-2folsh35 118 23 possibly possibly RB cord-007445-2folsh35 118 24 , , , cord-007445-2folsh35 118 25 for for IN cord-007445-2folsh35 118 26 the the DT cord-007445-2folsh35 118 27 synthesis synthesis NN cord-007445-2folsh35 118 28 of of IN cord-007445-2folsh35 118 29 a a DT cord-007445-2folsh35 118 30 variety variety NN cord-007445-2folsh35 118 31 of of IN cord-007445-2folsh35 118 32 inflammatory inflammatory JJ cord-007445-2folsh35 118 33 cyt~ cyt~ NN cord-007445-2folsh35 119 1 kines.~ kines.~ UH cord-007445-2folsh35 120 1 In in IN cord-007445-2folsh35 120 2 addition addition NN cord-007445-2folsh35 120 3 , , , cord-007445-2folsh35 120 4 nitric nitric NN cord-007445-2folsh35 120 5 oxide oxide NN cord-007445-2folsh35 120 6 may may MD cord-007445-2folsh35 120 7 regulate regulate VB cord-007445-2folsh35 120 8 virus virus NN cord-007445-2folsh35 120 9 - - HYPH cord-007445-2folsh35 120 10 induced induce VBN cord-007445-2folsh35 120 11 chemokine chemokine NN cord-007445-2folsh35 120 12 production production NN cord-007445-2folsh35 120 13 through through IN cord-007445-2folsh35 120 14 a a DT cord-007445-2folsh35 120 15 posttranscriptional posttranscriptional JJ cord-007445-2folsh35 120 16 mechanism mechanism NN cord-007445-2folsh35 120 17 and and CC cord-007445-2folsh35 120 18 by by IN cord-007445-2folsh35 120 19 inhibiting inhibit VBG cord-007445-2folsh35 120 20 viral viral JJ cord-007445-2folsh35 120 21 repli repli NNP cord-007445-2folsh35 120 22 ~ ~ NFP cord-007445-2folsh35 120 23 ation;~ ation;~ XX cord-007445-2folsh35 120 24 although although IN cord-007445-2folsh35 120 25 a a DT cord-007445-2folsh35 120 26 clinical clinical JJ cord-007445-2folsh35 120 27 study study NN cord-007445-2folsh35 120 28 did do VBD cord-007445-2folsh35 120 29 not not RB cord-007445-2folsh35 120 30 find find VB cord-007445-2folsh35 120 31 a a DT cord-007445-2folsh35 120 32 relationship relationship NN cord-007445-2folsh35 120 33 between between IN cord-007445-2folsh35 120 34 IL-8 il-8 NN cord-007445-2folsh35 120 35 and and CC cord-007445-2folsh35 120 36 nitrate nitrate NN cord-007445-2folsh35 120 37 levels level NNS cord-007445-2folsh35 120 38 in in IN cord-007445-2folsh35 120 39 nasal nasal NN cord-007445-2folsh35 120 40 secretion^.^^ secretion^.^^ NN cord-007445-2folsh35 120 41 Granulocyte Granulocyte NNP cord-007445-2folsh35 120 42 recruitment recruitment NN cord-007445-2folsh35 120 43 and and CC cord-007445-2folsh35 120 44 activation activation NN cord-007445-2folsh35 120 45 seem seem VBP cord-007445-2folsh35 120 46 to to TO cord-007445-2folsh35 120 47 have have VB cord-007445-2folsh35 120 48 an an DT cord-007445-2folsh35 120 49 important important JJ cord-007445-2folsh35 120 50 role role NN cord-007445-2folsh35 120 51 in in IN cord-007445-2folsh35 120 52 the the DT cord-007445-2folsh35 120 53 pathogenesis pathogenesis NN cord-007445-2folsh35 120 54 of of IN cord-007445-2folsh35 120 55 virus virus NN cord-007445-2folsh35 120 56 - - HYPH cord-007445-2folsh35 120 57 induced induce VBN cord-007445-2folsh35 120 58 asthma asthma NN cord-007445-2folsh35 120 59 exacerbations exacerbation NNS cord-007445-2folsh35 120 60 . . . cord-007445-2folsh35 121 1 Griinberg Griinberg NNP cord-007445-2folsh35 121 2 et et NNP cord-007445-2folsh35 121 3 a1Y1 a1Y1 NNP cord-007445-2folsh35 121 4 for for IN cord-007445-2folsh35 121 5 example example NN cord-007445-2folsh35 121 6 , , , cord-007445-2folsh35 121 7 experimentally experimentally RB cord-007445-2folsh35 121 8 inoculated inoculate VBD cord-007445-2folsh35 121 9 35 35 CD cord-007445-2folsh35 121 10 atopic atopic JJ cord-007445-2folsh35 121 11 asthma asthma NN cord-007445-2folsh35 121 12 subjects subject NNS cord-007445-2folsh35 121 13 with with IN cord-007445-2folsh35 121 14 either either CC cord-007445-2folsh35 121 15 RV16 RV16 NNP cord-007445-2folsh35 121 16 or or CC cord-007445-2folsh35 121 17 placebo placebo NN cord-007445-2folsh35 121 18 and and CC cord-007445-2folsh35 121 19 found find VBD cord-007445-2folsh35 121 20 that that IN cord-007445-2folsh35 121 21 neutrophil neutrophil NN cord-007445-2folsh35 121 22 counts count NNS cord-007445-2folsh35 121 23 in in IN cord-007445-2folsh35 121 24 the the DT cord-007445-2folsh35 121 25 peripheral peripheral JJ cord-007445-2folsh35 121 26 blood blood NN cord-007445-2folsh35 121 27 correlated correlate VBN cord-007445-2folsh35 121 28 with with IN cord-007445-2folsh35 121 29 the the DT cord-007445-2folsh35 121 30 cold cold JJ cord-007445-2folsh35 121 31 and and CC cord-007445-2folsh35 121 32 asthma asthma NN cord-007445-2folsh35 121 33 symptom symptom NN cord-007445-2folsh35 121 34 scores score NNS cord-007445-2folsh35 121 35 and and CC cord-007445-2folsh35 121 36 cold cold JJ cord-007445-2folsh35 121 37 - - HYPH cord-007445-2folsh35 121 38 induced induce VBN cord-007445-2folsh35 121 39 changes change NNS cord-007445-2folsh35 121 40 in in IN cord-007445-2folsh35 121 41 airway airway NNP cord-007445-2folsh35 121 42 hyperresponsiveness hyperresponsiveness NNP cord-007445-2folsh35 121 43 . . . cord-007445-2folsh35 122 1 In in IN cord-007445-2folsh35 122 2 addition addition NN cord-007445-2folsh35 122 3 , , , cord-007445-2folsh35 122 4 eosinophil eosinophil JJ cord-007445-2folsh35 122 5 granular granular JJ cord-007445-2folsh35 122 6 proteins protein NNS cord-007445-2folsh35 122 7 and and CC cord-007445-2folsh35 122 8 leukotriene leukotriene NN cord-007445-2folsh35 122 9 C C NNP cord-007445-2folsh35 122 10 , , , cord-007445-2folsh35 122 11 have have VBP cord-007445-2folsh35 122 12 been be VBN cord-007445-2folsh35 122 13 detected detect VBN cord-007445-2folsh35 122 14 in in IN cord-007445-2folsh35 122 15 the the DT cord-007445-2folsh35 122 16 nasal nasal NN cord-007445-2folsh35 122 17 secretions secretion NNS cord-007445-2folsh35 122 18 of of IN cord-007445-2folsh35 122 19 infants infant NNS cord-007445-2folsh35 122 20 and and CC cord-007445-2folsh35 122 21 children child NNS cord-007445-2folsh35 122 22 with with IN cord-007445-2folsh35 122 23 virus virus NN cord-007445-2folsh35 122 24 - - HYPH cord-007445-2folsh35 122 25 induced induce VBN cord-007445-2folsh35 122 26 wheezing wheeze VBG cord-007445-2folsh35 122 27 i i PRP cord-007445-2folsh35 122 28 l l NNP cord-007445-2folsh35 122 29 l l NN cord-007445-2folsh35 122 30 n n NN cord-007445-2folsh35 122 31 e e NN cord-007445-2folsh35 123 1 ~s ~s NNP cord-007445-2folsh35 123 2 e e NNP cord-007445-2folsh35 123 3 s s NNP cord-007445-2folsh35 123 4 .~~~ .~~~ . cord-007445-2folsh35 124 1 86 86 CD cord-007445-2folsh35 124 2 , , , cord-007445-2folsh35 124 3 97 97 CD cord-007445-2folsh35 124 4 , , , cord-007445-2folsh35 124 5 Increased increase VBN cord-007445-2folsh35 124 6 concentrations concentration NNS cord-007445-2folsh35 124 7 of of IN cord-007445-2folsh35 124 8 sputum sputum NN cord-007445-2folsh35 124 9 eosinophil eosinophil JJ cord-007445-2folsh35 124 10 cationic cationic JJ cord-007445-2folsh35 124 11 protein protein NN cord-007445-2folsh35 124 12 found find VBD cord-007445-2folsh35 124 13 during during IN cord-007445-2folsh35 124 14 the the DT cord-007445-2folsh35 124 15 acute acute JJ cord-007445-2folsh35 124 16 phase phase NN cord-007445-2folsh35 124 17 of of IN cord-007445-2folsh35 124 18 RV RV NNP cord-007445-2folsh35 124 19 infection infection NN cord-007445-2folsh35 124 20 corre corre JJ cord-007445-2folsh35 124 21 - - HYPH cord-007445-2folsh35 124 22 lated late VBN cord-007445-2folsh35 124 23 with with IN cord-007445-2folsh35 124 24 increases increase NNS cord-007445-2folsh35 124 25 in in IN cord-007445-2folsh35 124 26 airway airway NN cord-007445-2folsh35 124 27 responsiveness responsiveness NN cord-007445-2folsh35 124 28 in in IN cord-007445-2folsh35 124 29 a a DT cord-007445-2folsh35 124 30 group group NN cord-007445-2folsh35 124 31 of of IN cord-007445-2folsh35 124 32 adults adult NNS cord-007445-2folsh35 124 33 with with IN cord-007445-2folsh35 124 34 asthma asthma NN cord-007445-2folsh35 124 35 after after IN cord-007445-2folsh35 124 36 experimental experimental JJ cord-007445-2folsh35 124 37 inoculation inoculation NN cord-007445-2folsh35 124 38 with with IN cord-007445-2folsh35 124 39 RV16.39 rv16.39 NN cord-007445-2folsh35 125 1 In in IN cord-007445-2folsh35 125 2 vitro vitro FW cord-007445-2folsh35 125 3 experiments experiment NNS cord-007445-2folsh35 125 4 indicate indicate VBP cord-007445-2folsh35 125 5 that that IN cord-007445-2folsh35 125 6 RV RV NNP cord-007445-2folsh35 125 7 does do VBZ cord-007445-2folsh35 125 8 not not RB cord-007445-2folsh35 125 9 activate activate VB cord-007445-2folsh35 125 10 eosinophils eosinophils NN cord-007445-2folsh35 125 11 dire dire JJ cord-007445-2folsh35 125 12 ~ ~ NFP cord-007445-2folsh35 125 13 tly,~ tly,~ UH cord-007445-2folsh35 125 14 ; ; : cord-007445-2folsh35 125 15 it -PRON- PRP cord-007445-2folsh35 125 16 is be VBZ cord-007445-2folsh35 125 17 more more RBR cord-007445-2folsh35 125 18 likely likely JJ cord-007445-2folsh35 125 19 that that IN cord-007445-2folsh35 125 20 inflammatory inflammatory JJ cord-007445-2folsh35 125 21 mediators mediator NNS cord-007445-2folsh35 125 22 and and CC cord-007445-2folsh35 125 23 cytokines cytokine NNS cord-007445-2folsh35 125 24 , , , cord-007445-2folsh35 125 25 secreted secrete VBN cord-007445-2folsh35 125 26 by by IN cord-007445-2folsh35 125 27 virus virus NN cord-007445-2folsh35 125 28 - - HYPH cord-007445-2folsh35 125 29 activated activate VBN cord-007445-2folsh35 125 30 cells cell NNS cord-007445-2folsh35 125 31 in in IN cord-007445-2folsh35 125 32 the the DT cord-007445-2folsh35 125 33 lung lung NN cord-007445-2folsh35 125 34 , , , cord-007445-2folsh35 125 35 contribute contribute VBP cord-007445-2folsh35 125 36 to to IN cord-007445-2folsh35 125 37 eosinophil eosinophil JJ cord-007445-2folsh35 125 38 activation activation NN cord-007445-2folsh35 125 39 . . . cord-007445-2folsh35 126 1 Finally finally RB cord-007445-2folsh35 126 2 , , , cord-007445-2folsh35 126 3 guinea guinea NN cord-007445-2folsh35 126 4 pigs pig NNS cord-007445-2folsh35 126 5 infected infect VBN cord-007445-2folsh35 126 6 with with IN cord-007445-2folsh35 126 7 PIV PIV NNP cord-007445-2folsh35 126 8 develop develop VB cord-007445-2folsh35 126 9 airway airway NN cord-007445-2folsh35 126 10 eosinophils eosinophil NNS cord-007445-2folsh35 126 11 and and CC cord-007445-2folsh35 126 12 airway airway NN cord-007445-2folsh35 126 13 hyperresponsive- hyperresponsive- NN cord-007445-2folsh35 127 1 nessZ5 nessZ5 NNP cord-007445-2folsh35 127 2 and and CC cord-007445-2folsh35 127 3 this this DT cord-007445-2folsh35 127 4 outcome outcome NN cord-007445-2folsh35 127 5 is be VBZ cord-007445-2folsh35 127 6 blocked block VBN cord-007445-2folsh35 127 7 if if IN cord-007445-2folsh35 127 8 the the DT cord-007445-2folsh35 127 9 guinea guinea NN cord-007445-2folsh35 127 10 pigs pig NNS cord-007445-2folsh35 127 11 are be VBP cord-007445-2folsh35 127 12 pretreated pretreate VBN cord-007445-2folsh35 127 13 with with IN cord-007445-2folsh35 127 14 IL-5neutralizing IL-5neutralizing NNP cord-007445-2folsh35 127 15 antibody.l12 antibody.l12 NNP cord-007445-2folsh35 128 1 Most Most JJS cord-007445-2folsh35 128 2 respiratory respiratory JJ cord-007445-2folsh35 128 3 viruses virus NNS cord-007445-2folsh35 128 4 replicate replicate VBP cord-007445-2folsh35 128 5 quickly quickly RB cord-007445-2folsh35 128 6 and and CC cord-007445-2folsh35 128 7 , , , cord-007445-2folsh35 128 8 within within IN cord-007445-2folsh35 128 9 a a DT cord-007445-2folsh35 128 10 few few JJ cord-007445-2folsh35 128 11 days day NNS cord-007445-2folsh35 128 12 of of IN cord-007445-2folsh35 128 13 inoculation inoculation NN cord-007445-2folsh35 128 14 , , , cord-007445-2folsh35 128 15 the the DT cord-007445-2folsh35 128 16 quantity quantity NN cord-007445-2folsh35 128 17 of of IN cord-007445-2folsh35 128 18 viruses virus NNS cord-007445-2folsh35 128 19 and and CC cord-007445-2folsh35 128 20 viral viral JJ cord-007445-2folsh35 128 21 proteins protein NNS cord-007445-2folsh35 128 22 is be VBZ cord-007445-2folsh35 128 23 sufficient sufficient JJ cord-007445-2folsh35 128 24 to to TO cord-007445-2folsh35 128 25 activate activate VB cord-007445-2folsh35 128 26 mononuclear mononuclear JJ cord-007445-2folsh35 128 27 cells cell NNS cord-007445-2folsh35 128 28 in in IN cord-007445-2folsh35 128 29 the the DT cord-007445-2folsh35 128 30 airway airway NN cord-007445-2folsh35 128 31 . . . cord-007445-2folsh35 129 1 In in IN cord-007445-2folsh35 129 2 vitro vitro FW cord-007445-2folsh35 129 3 infection infection NN cord-007445-2folsh35 129 4 of of IN cord-007445-2folsh35 129 5 human human JJ cord-007445-2folsh35 129 6 monocytes monocyte NNS cord-007445-2folsh35 129 7 with with IN cord-007445-2folsh35 129 8 respiratory respiratory JJ cord-007445-2folsh35 129 9 viruses virus NNS cord-007445-2folsh35 129 10 , , , cord-007445-2folsh35 129 11 for for IN cord-007445-2folsh35 129 12 example example NN cord-007445-2folsh35 129 13 , , , cord-007445-2folsh35 129 14 leads lead VBZ cord-007445-2folsh35 129 15 to to IN cord-007445-2folsh35 129 16 a a DT cord-007445-2folsh35 129 17 potent potent JJ cord-007445-2folsh35 129 18 proinflammatory proinflammatory JJ cord-007445-2folsh35 129 19 cytokine cytokine NN cord-007445-2folsh35 129 20 response response NN cord-007445-2folsh35 129 21 by by IN cord-007445-2folsh35 129 22 release release NN cord-007445-2folsh35 129 23 of of IN cord-007445-2folsh35 129 24 IL-8 IL-8 NNP cord-007445-2folsh35 129 25 , , , cord-007445-2folsh35 129 26 IL-1 IL-1 NNP cord-007445-2folsh35 129 27 , , , cord-007445-2folsh35 129 28 and and CC cord-007445-2folsh35 129 29 TNF tnf NN cord-007445-2folsh35 129 30 - - HYPH cord-007445-2folsh35 129 31 CX.~~ CX.~~ NNS cord-007445-2folsh35 129 32 , , , cord-007445-2folsh35 129 33 54 54 CD cord-007445-2folsh35 129 34 , , , cord-007445-2folsh35 129 35 90 90 CD cord-007445-2folsh35 129 36 Interleukin-1 Interleukin-1 NNP cord-007445-2folsh35 129 37 and and CC cord-007445-2folsh35 129 38 TNF TNF NNP cord-007445-2folsh35 129 39 - - , cord-007445-2folsh35 129 40 a a DT cord-007445-2folsh35 129 41 can can MD cord-007445-2folsh35 129 42 increase increase VB cord-007445-2folsh35 129 43 cell cell NN cord-007445-2folsh35 129 44 recruitment recruitment NN cord-007445-2folsh35 129 45 into into IN cord-007445-2folsh35 129 46 the the DT cord-007445-2folsh35 129 47 airway airway NN cord-007445-2folsh35 129 48 by by IN cord-007445-2folsh35 129 49 enhancing enhance VBG cord-007445-2folsh35 129 50 adhesion adhesion NN cord-007445-2folsh35 129 51 molecule molecule NN cord-007445-2folsh35 129 52 expression expression NN cord-007445-2folsh35 129 53 on on IN cord-007445-2folsh35 129 54 endothelial endothelial JJ cord-007445-2folsh35 129 55 cells cell NNS cord-007445-2folsh35 129 56 . . . cord-007445-2folsh35 130 1 In in IN cord-007445-2folsh35 130 2 addition addition NN cord-007445-2folsh35 130 3 , , , cord-007445-2folsh35 130 4 TNF TNF NNP cord-007445-2folsh35 130 5 - - , cord-007445-2folsh35 130 6 a a NNP cord-007445-2folsh35 130 7 has have VBZ cord-007445-2folsh35 130 8 been be VBN cord-007445-2folsh35 130 9 associated associate VBN cord-007445-2folsh35 130 10 with with IN cord-007445-2folsh35 130 11 wheezing wheeze VBG cord-007445-2folsh35 130 12 illnesses illness NNS cord-007445-2folsh35 130 13 in in IN cord-007445-2folsh35 130 14 infancy6 infancy6 NN cord-007445-2folsh35 130 15 and and CC cord-007445-2folsh35 130 16 the the DT cord-007445-2folsh35 130 17 development development NN cord-007445-2folsh35 130 18 of of IN cord-007445-2folsh35 130 19 late late JJ cord-007445-2folsh35 130 20 - - HYPH cord-007445-2folsh35 130 21 phase phase NN cord-007445-2folsh35 130 22 allergic allergic JJ cord-007445-2folsh35 130 23 reaction reaction NN cord-007445-2folsh35 130 24 and and CC cord-007445-2folsh35 130 25 asthma.3 asthma.3 NNS cord-007445-2folsh35 130 26 , , , cord-007445-2folsh35 130 27 37 37 CD cord-007445-2folsh35 130 28 Monocytes monocyte NNS cord-007445-2folsh35 130 29 and and CC cord-007445-2folsh35 130 30 macrophages macrophage NNS cord-007445-2folsh35 130 31 also also RB cord-007445-2folsh35 130 32 produce produce VBP cord-007445-2folsh35 130 33 interferon interferon NN cord-007445-2folsh35 130 34 ( ( -LRB- cord-007445-2folsh35 130 35 INF INF NNP cord-007445-2folsh35 130 36 ) ) -RRB- cord-007445-2folsh35 130 37 , , , cord-007445-2folsh35 130 38 and and CC cord-007445-2folsh35 130 39 its -PRON- PRP$ cord-007445-2folsh35 130 40 appearance appearance NN cord-007445-2folsh35 130 41 in in IN cord-007445-2folsh35 130 42 nasal nasal NN cord-007445-2folsh35 130 43 secretions secretion NNS cord-007445-2folsh35 130 44 coincides coincide VBZ cord-007445-2folsh35 130 45 with with IN cord-007445-2folsh35 130 46 the the DT cord-007445-2folsh35 130 47 onset onset NN cord-007445-2folsh35 130 48 of of IN cord-007445-2folsh35 130 49 the the DT cord-007445-2folsh35 130 50 recovery recovery NN cord-007445-2folsh35 130 51 process process NN cord-007445-2folsh35 130 52 . . . cord-007445-2folsh35 131 1 In in IN cord-007445-2folsh35 131 2 addition addition NN cord-007445-2folsh35 131 3 to to IN cord-007445-2folsh35 131 4 cytokine cytokine NN cord-007445-2folsh35 131 5 production production NN cord-007445-2folsh35 131 6 , , , cord-007445-2folsh35 131 7 macrophages macrophage NNS cord-007445-2folsh35 131 8 incubated incubate VBN cord-007445-2folsh35 131 9 with with IN cord-007445-2folsh35 131 10 RSV RSV NNP cord-007445-2folsh35 131 11 or or CC cord-007445-2folsh35 131 12 PIV PIV NNP cord-007445-2folsh35 131 13 produce produce VBP cord-007445-2folsh35 131 14 lipid lipid NN cord-007445-2folsh35 131 15 mediators mediator NNS cord-007445-2folsh35 131 16 such such JJ cord-007445-2folsh35 131 17 as as IN cord-007445-2folsh35 131 18 prostaglandin prostaglandin NN cord-007445-2folsh35 131 19 E e NN cord-007445-2folsh35 131 20 , , , cord-007445-2folsh35 131 21 platelet platelet NN cord-007445-2folsh35 131 22 - - HYPH cord-007445-2folsh35 131 23 activating activate VBG cord-007445-2folsh35 131 24 factor factor NN cord-007445-2folsh35 131 25 , , , cord-007445-2folsh35 131 26 and and CC cord-007445-2folsh35 131 27 thromboxane thromboxane NN cord-007445-2folsh35 131 28 B248 B248 NNP cord-007445-2folsh35 131 29 , , , cord-007445-2folsh35 131 30 78 78 CD cord-007445-2folsh35 131 31 , , , cord-007445-2folsh35 131 32 114 114 CD cord-007445-2folsh35 131 33 that that WDT cord-007445-2folsh35 131 34 can can MD cord-007445-2folsh35 131 35 augment augment VB cord-007445-2folsh35 131 36 airway airway NN cord-007445-2folsh35 131 37 inflammation inflammation NN cord-007445-2folsh35 131 38 . . . cord-007445-2folsh35 132 1 Lymphocytes lymphocyte NNS cord-007445-2folsh35 132 2 , , , cord-007445-2folsh35 132 3 including include VBG cord-007445-2folsh35 132 4 natural natural JJ cord-007445-2folsh35 132 5 killer killer NN cord-007445-2folsh35 132 6 cells cell NNS cord-007445-2folsh35 132 7 , , , cord-007445-2folsh35 132 8 CD8 CD8 NNP cord-007445-2folsh35 132 9 + + CC cord-007445-2folsh35 132 10 cytotoxic cytotoxic JJ cord-007445-2folsh35 132 11 T t NN cord-007445-2folsh35 132 12 cells cell NNS cord-007445-2folsh35 132 13 , , , cord-007445-2folsh35 132 14 and and CC cord-007445-2folsh35 132 15 CD4 CD4 NNP cord-007445-2folsh35 132 16 + + CC cord-007445-2folsh35 132 17 T t NN cord-007445-2folsh35 132 18 cells cell NNS cord-007445-2folsh35 132 19 , , , cord-007445-2folsh35 132 20 are be VBP cord-007445-2folsh35 132 21 involved involve VBN cord-007445-2folsh35 132 22 in in IN cord-007445-2folsh35 132 23 limiting limit VBG cord-007445-2folsh35 132 24 viral viral JJ cord-007445-2folsh35 132 25 replication replication NN cord-007445-2folsh35 132 26 and and CC cord-007445-2folsh35 132 27 viral viral JJ cord-007445-2folsh35 132 28 clearance clearance NN cord-007445-2folsh35 132 29 . . . cord-007445-2folsh35 133 1 To to TO cord-007445-2folsh35 133 2 test test VB cord-007445-2folsh35 133 3 the the DT cord-007445-2folsh35 133 4 possibility possibility NN cord-007445-2folsh35 133 5 that that IN cord-007445-2folsh35 133 6 variations variation NNS cord-007445-2folsh35 133 7 in in IN cord-007445-2folsh35 133 8 lymphocyte lymphocyte NN cord-007445-2folsh35 133 9 responses response NNS cord-007445-2folsh35 133 10 might may MD cord-007445-2folsh35 133 11 account account VB cord-007445-2folsh35 133 12 for for IN cord-007445-2folsh35 133 13 variability variability NN cord-007445-2folsh35 133 14 in in IN cord-007445-2folsh35 133 15 the the DT cord-007445-2folsh35 133 16 ability ability NN cord-007445-2folsh35 133 17 to to TO cord-007445-2folsh35 133 18 clear clear VB cord-007445-2folsh35 133 19 viral viral JJ cord-007445-2folsh35 133 20 infections infection NNS cord-007445-2folsh35 133 21 , , , cord-007445-2folsh35 133 22 Parry Parry NNP cord-007445-2folsh35 133 23 et et NNP cord-007445-2folsh35 133 24 aPO apo NN cord-007445-2folsh35 133 25 measured measure VBN cord-007445-2folsh35 133 26 in in IN cord-007445-2folsh35 133 27 vitro vitro FW cord-007445-2folsh35 133 28 lymphocyte lymphocyte NN cord-007445-2folsh35 133 29 responses response NNS cord-007445-2folsh35 133 30 in in IN cord-007445-2folsh35 133 31 a a DT cord-007445-2folsh35 133 32 group group NN cord-007445-2folsh35 133 33 of of IN cord-007445-2folsh35 133 34 allergic allergic JJ cord-007445-2folsh35 133 35 subjects subject NNS cord-007445-2folsh35 133 36 who who WP cord-007445-2folsh35 133 37 were be VBD cord-007445-2folsh35 133 38 then then RB cord-007445-2folsh35 133 39 inoculated inoculate VBN cord-007445-2folsh35 133 40 with with IN cord-007445-2folsh35 133 41 RV RV NNP cord-007445-2folsh35 133 42 16 16 CD cord-007445-2folsh35 133 43 . . . cord-007445-2folsh35 134 1 Vigorous vigorous JJ cord-007445-2folsh35 134 2 virus virus NN cord-007445-2folsh35 134 3 - - HYPH cord-007445-2folsh35 134 4 induced induce VBN cord-007445-2folsh35 134 5 responses response NNS cord-007445-2folsh35 134 6 ( ( -LRB- cord-007445-2folsh35 134 7 lymphocyte lymphocyte NN cord-007445-2folsh35 134 8 proliferation proliferation NN cord-007445-2folsh35 134 9 or or CC cord-007445-2folsh35 134 10 IFN IFN NNP cord-007445-2folsh35 134 11 -- -- : cord-007445-2folsh35 134 12 y y NNP cord-007445-2folsh35 134 13 secretion secretion NN cord-007445-2folsh35 134 14 ) ) -RRB- cord-007445-2folsh35 134 15 before before IN cord-007445-2folsh35 134 16 inoculation inoculation NN cord-007445-2folsh35 134 17 correlated correlate VBN cord-007445-2folsh35 134 18 with with IN cord-007445-2folsh35 134 19 reduced reduce VBN cord-007445-2folsh35 134 20 viral viral JJ cord-007445-2folsh35 134 21 shedding shed VBG cord-007445-2folsh35 134 22 after after IN cord-007445-2folsh35 134 23 inoculation inoculation NN cord-007445-2folsh35 134 24 . . . cord-007445-2folsh35 135 1 These these DT cord-007445-2folsh35 135 2 results result NNS cord-007445-2folsh35 135 3 sug sug NN cord-007445-2folsh35 135 4 - - HYPH cord-007445-2folsh35 135 5 gest gest NNP cord-007445-2folsh35 135 6 that that WDT cord-007445-2folsh35 135 7 factors factor NNS cord-007445-2folsh35 135 8 related relate VBN cord-007445-2folsh35 135 9 to to IN cord-007445-2folsh35 135 10 the the DT cord-007445-2folsh35 135 11 host host NN cord-007445-2folsh35 135 12 cellular cellular JJ cord-007445-2folsh35 135 13 response response NN cord-007445-2folsh35 135 14 help help NN cord-007445-2folsh35 135 15 determine determine VB cord-007445-2folsh35 135 16 the the DT cord-007445-2folsh35 135 17 degree degree NN cord-007445-2folsh35 135 18 of of IN cord-007445-2folsh35 135 19 viral viral JJ cord-007445-2folsh35 135 20 replication replication NN cord-007445-2folsh35 135 21 during during IN cord-007445-2folsh35 135 22 respiratory respiratory JJ cord-007445-2folsh35 135 23 viral viral JJ cord-007445-2folsh35 135 24 infections infection NNS cord-007445-2folsh35 135 25 . . . cord-007445-2folsh35 136 1 Further further JJ cord-007445-2folsh35 136 2 characterization characterization NN cord-007445-2folsh35 136 3 of of IN cord-007445-2folsh35 136 4 these these DT cord-007445-2folsh35 136 5 host host NN cord-007445-2folsh35 136 6 factors factor NNS cord-007445-2folsh35 136 7 may may MD cord-007445-2folsh35 136 8 lead lead VB cord-007445-2folsh35 136 9 to to IN cord-007445-2folsh35 136 10 new new JJ cord-007445-2folsh35 136 11 therapeutic therapeutic JJ cord-007445-2folsh35 136 12 strategies strategy NNS cord-007445-2folsh35 136 13 for for IN cord-007445-2folsh35 136 14 respiratory respiratory JJ cord-007445-2folsh35 136 15 infections infection NNS cord-007445-2folsh35 136 16 , , , cord-007445-2folsh35 136 17 a a DT cord-007445-2folsh35 136 18 goal goal NN cord-007445-2folsh35 136 19 that that WDT cord-007445-2folsh35 136 20 is be VBZ cord-007445-2folsh35 136 21 particularly particularly RB cord-007445-2folsh35 136 22 important important JJ cord-007445-2folsh35 136 23 for for IN cord-007445-2folsh35 136 24 people people NNS cord-007445-2folsh35 136 25 with with IN cord-007445-2folsh35 136 26 asthma asthma NN cord-007445-2folsh35 136 27 . . . cord-007445-2folsh35 137 1 Several several JJ cord-007445-2folsh35 137 2 studies study NNS cord-007445-2folsh35 137 3 have have VBP cord-007445-2folsh35 137 4 shown show VBN cord-007445-2folsh35 137 5 that that IN cord-007445-2folsh35 137 6 viral viral JJ cord-007445-2folsh35 137 7 infections infection NNS cord-007445-2folsh35 137 8 activate activate VBP cord-007445-2folsh35 137 9 a a DT cord-007445-2folsh35 137 10 wide wide JJ cord-007445-2folsh35 137 11 range range NN cord-007445-2folsh35 137 12 of of IN cord-007445-2folsh35 137 13 T t NN cord-007445-2folsh35 137 14 cells cell NNS cord-007445-2folsh35 137 15 . . . cord-007445-2folsh35 138 1 Evidence evidence NN cord-007445-2folsh35 138 2 for for IN cord-007445-2folsh35 138 3 this this DT cord-007445-2folsh35 138 4 comes come VBZ cord-007445-2folsh35 138 5 from from IN cord-007445-2folsh35 138 6 experiments experiment NNS cord-007445-2folsh35 138 7 in in IN cord-007445-2folsh35 138 8 mice mouse NNS cord-007445-2folsh35 138 9 , , , cord-007445-2folsh35 138 10 in in IN cord-007445-2folsh35 138 11 which which WDT cord-007445-2folsh35 138 12 most most JJS cord-007445-2folsh35 138 13 of of IN cord-007445-2folsh35 138 14 the the DT cord-007445-2folsh35 138 15 T t NN cord-007445-2folsh35 138 16 cells cell NNS cord-007445-2folsh35 138 17 found find VBN cord-007445-2folsh35 138 18 in in IN cord-007445-2folsh35 138 19 the the DT cord-007445-2folsh35 138 20 lung lung NN cord-007445-2folsh35 138 21 after after IN cord-007445-2folsh35 138 22 an an DT cord-007445-2folsh35 138 23 acute acute JJ cord-007445-2folsh35 138 24 viral viral JJ cord-007445-2folsh35 138 25 infection infection NN cord-007445-2folsh35 138 26 are be VBP cord-007445-2folsh35 138 27 not not RB cord-007445-2folsh35 138 28 virus virus NN cord-007445-2folsh35 138 29 - - : cord-007445-2folsh35 138 30 specific,2l specific,2l JJ cord-007445-2folsh35 138 31 and and CC cord-007445-2folsh35 138 32 in in IN cord-007445-2folsh35 138 33 vitro vitro FW cord-007445-2folsh35 138 34 studies study NNS cord-007445-2folsh35 138 35 , , , cord-007445-2folsh35 139 1 in in IN cord-007445-2folsh35 139 2 which which WDT cord-007445-2folsh35 139 3 25 25 CD cord-007445-2folsh35 139 4 % % NN cord-007445-2folsh35 139 5 to to IN cord-007445-2folsh35 139 6 50 50 CD cord-007445-2folsh35 139 7 % % NN cord-007445-2folsh35 139 8 of of IN cord-007445-2folsh35 139 9 human human JJ cord-007445-2folsh35 139 10 peripheral peripheral JJ cord-007445-2folsh35 139 11 blood blood NN cord-007445-2folsh35 139 12 T T NNP cord-007445-2folsh35 139 13 cells cell NNS cord-007445-2folsh35 139 14 express express VBP cord-007445-2folsh35 139 15 the the DT cord-007445-2folsh35 139 16 early early JJ cord-007445-2folsh35 139 17 activation activation NN cord-007445-2folsh35 139 18 marker marker NN cord-007445-2folsh35 139 19 CD69 CD69 NNP cord-007445-2folsh35 139 20 after after IN cord-007445-2folsh35 139 21 24 24 CD cord-007445-2folsh35 139 22 hours hour NNS cord-007445-2folsh35 139 23 in in IN cord-007445-2folsh35 139 24 culture culture NN cord-007445-2folsh35 139 25 with with IN cord-007445-2folsh35 139 26 RV.36 rv.36 CD cord-007445-2folsh35 139 27 RANTES RANTES NNPS cord-007445-2folsh35 139 28 , , , cord-007445-2folsh35 139 29 induced induce VBN cord-007445-2folsh35 139 30 by by IN cord-007445-2folsh35 139 31 respiratory respiratory JJ cord-007445-2folsh35 139 32 viruses virus NNS cord-007445-2folsh35 139 33 , , , cord-007445-2folsh35 139 34 at at IN cord-007445-2folsh35 139 35 high high JJ cord-007445-2folsh35 139 36 concentrations concentration NNS cord-007445-2folsh35 139 37 can can MD cord-007445-2folsh35 139 38 also also RB cord-007445-2folsh35 139 39 induce induce VB cord-007445-2folsh35 139 40 antigen antigen NN cord-007445-2folsh35 139 41 - - HYPH cord-007445-2folsh35 139 42 independent independent JJ cord-007445-2folsh35 139 43 T t NN cord-007445-2folsh35 139 44 - - HYPH cord-007445-2folsh35 139 45 cell cell NN cord-007445-2folsh35 139 46 activation activation NN cord-007445-2folsh35 139 47 ? ? . cord-007445-2folsh35 140 1 These these DT cord-007445-2folsh35 140 2 studies study NNS cord-007445-2folsh35 140 3 suggest suggest VBP cord-007445-2folsh35 140 4 that that IN cord-007445-2folsh35 140 5 respiratory respiratory JJ cord-007445-2folsh35 140 6 viruses virus NNS cord-007445-2folsh35 140 7 can can MD cord-007445-2folsh35 140 8 induce induce VB cord-007445-2folsh35 140 9 early early RB cord-007445-2folsh35 140 10 , , , cord-007445-2folsh35 140 11 nonspecific nonspecific JJ cord-007445-2folsh35 140 12 T t NN cord-007445-2folsh35 140 13 - - HYPH cord-007445-2folsh35 140 14 cell cell NN cord-007445-2folsh35 140 15 activation activation NN cord-007445-2folsh35 140 16 and and CC cord-007445-2folsh35 140 17 recruitment recruitment NN cord-007445-2folsh35 140 18 that that WDT cord-007445-2folsh35 140 19 could could MD cord-007445-2folsh35 140 20 significantly significantly RB cord-007445-2folsh35 140 21 increase increase VB cord-007445-2folsh35 140 22 the the DT cord-007445-2folsh35 140 23 intensity intensity NN cord-007445-2folsh35 140 24 of of IN cord-007445-2folsh35 140 25 airway airway NN cord-007445-2folsh35 140 26 inflammation inflammation NN cord-007445-2folsh35 140 27 , , , cord-007445-2folsh35 140 28 resulting result VBG cord-007445-2folsh35 140 29 in in IN cord-007445-2folsh35 140 30 airway airway NN cord-007445-2folsh35 140 31 dysfunction dysfunction NN cord-007445-2folsh35 140 32 and and CC cord-007445-2folsh35 140 33 respiratory respiratory JJ cord-007445-2folsh35 140 34 symptoms symptom NNS cord-007445-2folsh35 140 35 . . . cord-007445-2folsh35 141 1 This this DT cord-007445-2folsh35 141 2 hypothesis hypothesis NN cord-007445-2folsh35 141 3 is be VBZ cord-007445-2folsh35 141 4 supported support VBN cord-007445-2folsh35 141 5 by by IN cord-007445-2folsh35 141 6 studies study NNS cord-007445-2folsh35 141 7 of of IN cord-007445-2folsh35 141 8 volunteers volunteer NNS cord-007445-2folsh35 141 9 infected infect VBN cord-007445-2folsh35 141 10 with with IN cord-007445-2folsh35 141 11 rhinovirus rhinovirus NN cord-007445-2folsh35 141 12 . . . cord-007445-2folsh35 142 1 Respiratory respiratory JJ cord-007445-2folsh35 142 2 virus virus NN cord-007445-2folsh35 142 3 infections infection NNS cord-007445-2folsh35 142 4 usually usually RB cord-007445-2folsh35 142 5 cause cause VBP cord-007445-2folsh35 142 6 peripheral peripheral JJ cord-007445-2folsh35 142 7 lymphopenia lymphopenia NN cord-007445-2folsh35 142 8 and and CC cord-007445-2folsh35 142 9 increased increase VBN cord-007445-2folsh35 142 10 numbers number NNS cord-007445-2folsh35 142 11 of of IN cord-007445-2folsh35 142 12 lymphocytes lymphocyte NNS cord-007445-2folsh35 142 13 in in IN cord-007445-2folsh35 142 14 the the DT cord-007445-2folsh35 142 15 upper upper JJ cord-007445-2folsh35 142 16 and and CC cord-007445-2folsh35 142 17 lower low JJR cord-007445-2folsh35 142 18 airways airway NNS cord-007445-2folsh35 142 19 , , , cord-007445-2folsh35 142 20 for for IN cord-007445-2folsh35 142 21 example example NN cord-007445-2folsh35 142 22 . . . cord-007445-2folsh35 143 1 The the DT cord-007445-2folsh35 143 2 degree degree NN cord-007445-2folsh35 143 3 of of IN cord-007445-2folsh35 143 4 peripheral peripheral JJ cord-007445-2folsh35 143 5 blood blood NN cord-007445-2folsh35 143 6 lymphopenia lymphopenia NNP cord-007445-2folsh35 143 7 and and CC cord-007445-2folsh35 143 8 lymphocytic lymphocytic JJ cord-007445-2folsh35 143 9 infiltration infiltration NN cord-007445-2folsh35 143 10 of of IN cord-007445-2folsh35 143 11 the the DT cord-007445-2folsh35 143 12 airway airway NN cord-007445-2folsh35 143 13 epithelium epithelium NN cord-007445-2folsh35 143 14 has have VBZ cord-007445-2folsh35 143 15 been be VBN cord-007445-2folsh35 143 16 correlated correlate VBN cord-007445-2folsh35 143 17 with with IN cord-007445-2folsh35 143 18 the the DT cord-007445-2folsh35 143 19 increases increase NNS cord-007445-2folsh35 143 20 in in IN cord-007445-2folsh35 143 21 airway airway NN cord-007445-2folsh35 143 22 responsi responsi NNP cord-007445-2folsh35 143 23 ~ ~ NFP cord-007445-2folsh35 143 24 eness.~~~ eness.~~~ NNP cord-007445-2folsh35 143 25 26 26 CD cord-007445-2folsh35 144 1 Although although IN cord-007445-2folsh35 144 2 viral viral JJ cord-007445-2folsh35 144 3 infections infection NNS cord-007445-2folsh35 144 4 cause cause VBP cord-007445-2folsh35 144 5 similar similar JJ cord-007445-2folsh35 144 6 upper upper JJ cord-007445-2folsh35 144 7 respiratory respiratory JJ cord-007445-2folsh35 144 8 symptoms symptom NNS cord-007445-2folsh35 144 9 in in IN cord-007445-2folsh35 144 10 allergic allergic JJ cord-007445-2folsh35 144 11 and and CC cord-007445-2folsh35 144 12 nonallergic nonallergic NNP cord-007445-2folsh35 144 13 individual^,^^ individual^,^^ NNP cord-007445-2folsh35 144 14 , , , cord-007445-2folsh35 144 15 loo loo FW cord-007445-2folsh35 144 16 there there EX cord-007445-2folsh35 144 17 is be VBZ cord-007445-2folsh35 144 18 evidence evidence NN cord-007445-2folsh35 144 19 of of IN cord-007445-2folsh35 144 20 interactions interaction NNS cord-007445-2folsh35 144 21 between between IN cord-007445-2folsh35 144 22 virus virus NN cord-007445-2folsh35 144 23 - - : cord-007445-2folsh35 144 24 and and CC cord-007445-2folsh35 144 25 allergen allergen NN cord-007445-2folsh35 144 26 - - HYPH cord-007445-2folsh35 144 27 induced induce VBN cord-007445-2folsh35 144 28 responses response NNS cord-007445-2folsh35 144 29 in in IN cord-007445-2folsh35 144 30 the the DT cord-007445-2folsh35 144 31 lower low JJR cord-007445-2folsh35 144 32 airway airway NN cord-007445-2folsh35 144 33 . . . cord-007445-2folsh35 145 1 Lemanske Lemanske NNP cord-007445-2folsh35 145 2 and and CC cord-007445-2folsh35 145 3 colleag colleag NN cord-007445-2folsh35 145 4 ~ ~ NFP cord-007445-2folsh35 145 5 es,~~ es,~~ NNP cord-007445-2folsh35 145 6 for for IN cord-007445-2folsh35 145 7 example example NN cord-007445-2folsh35 145 8 , , , cord-007445-2folsh35 145 9 identified identify VBD cord-007445-2folsh35 145 10 10 10 CD cord-007445-2folsh35 145 11 patients patient NNS cord-007445-2folsh35 145 12 with with IN cord-007445-2folsh35 145 13 allergic allergic JJ cord-007445-2folsh35 145 14 rhinitis rhinitis NN cord-007445-2folsh35 145 15 and and CC cord-007445-2folsh35 145 16 experimentally experimentally RB cord-007445-2folsh35 145 17 infected infect VBD cord-007445-2folsh35 145 18 them -PRON- PRP cord-007445-2folsh35 145 19 with with IN cord-007445-2folsh35 145 20 RV16 RV16 NNP cord-007445-2folsh35 145 21 . . . cord-007445-2folsh35 146 1 The the DT cord-007445-2folsh35 146 2 viral viral JJ cord-007445-2folsh35 146 3 infection infection NN cord-007445-2folsh35 146 4 increased increase VBD cord-007445-2folsh35 146 5 airway airway NN cord-007445-2folsh35 146 6 reactivity reactivity NN cord-007445-2folsh35 146 7 to to IN cord-007445-2folsh35 146 8 both both CC cord-007445-2folsh35 146 9 inhaled inhale VBN cord-007445-2folsh35 146 10 allergen allergen NN cord-007445-2folsh35 146 11 and and CC cord-007445-2folsh35 146 12 histamine histamine NN cord-007445-2folsh35 146 13 , , , cord-007445-2folsh35 146 14 and and CC cord-007445-2folsh35 146 15 also also RB cord-007445-2folsh35 146 16 increased increase VBD cord-007445-2folsh35 146 17 the the DT cord-007445-2folsh35 146 18 frequency frequency NN cord-007445-2folsh35 146 19 of of IN cord-007445-2folsh35 146 20 a a DT cord-007445-2folsh35 146 21 late late JJ cord-007445-2folsh35 146 22 allergic allergic JJ cord-007445-2folsh35 146 23 reaction reaction NN cord-007445-2folsh35 146 24 to to IN cord-007445-2folsh35 146 25 inhaled inhale VBN cord-007445-2folsh35 146 26 antigens antigen NNS cord-007445-2folsh35 146 27 . . . cord-007445-2folsh35 147 1 Moreover moreover RB cord-007445-2folsh35 147 2 , , , cord-007445-2folsh35 147 3 Calhoun Calhoun NNP cord-007445-2folsh35 147 4 and and CC cord-007445-2folsh35 147 5 colleag colleag NNP cord-007445-2folsh35 147 6 ~ ~ CD cord-007445-2folsh35 147 7 es'~ es'~ : cord-007445-2folsh35 147 8 used use VBN cord-007445-2folsh35 147 9 bronchoscopy bronchoscopy NN cord-007445-2folsh35 147 10 to to TO cord-007445-2folsh35 147 11 study study VB cord-007445-2folsh35 147 12 the the DT cord-007445-2folsh35 147 13 inflammatory inflammatory JJ cord-007445-2folsh35 147 14 response response NN cord-007445-2folsh35 147 15 to to IN cord-007445-2folsh35 147 16 allergen allergen NN cord-007445-2folsh35 147 17 in in IN cord-007445-2folsh35 147 18 indi indi NNP cord-007445-2folsh35 147 19 - - HYPH cord-007445-2folsh35 147 20 vidual vidual JJ cord-007445-2folsh35 147 21 lung lung NN cord-007445-2folsh35 147 22 segments segment NNS cord-007445-2folsh35 147 23 before before RB cord-007445-2folsh35 147 24 , , , cord-007445-2folsh35 147 25 during during IN cord-007445-2folsh35 147 26 , , , cord-007445-2folsh35 147 27 and and CC cord-007445-2folsh35 147 28 1 1 CD cord-007445-2folsh35 147 29 month month NN cord-007445-2folsh35 147 30 after after IN cord-007445-2folsh35 147 31 RV16 RV16 NNP cord-007445-2folsh35 147 32 infection infection NN cord-007445-2folsh35 147 33 . . . cord-007445-2folsh35 148 1 RV rv NN cord-007445-2folsh35 148 2 infection infection NN cord-007445-2folsh35 148 3 enhanced enhance VBD cord-007445-2folsh35 148 4 the the DT cord-007445-2folsh35 148 5 immediate immediate JJ cord-007445-2folsh35 148 6 antigen antigen NN cord-007445-2folsh35 148 7 - - HYPH cord-007445-2folsh35 148 8 induced induce VBN cord-007445-2folsh35 148 9 release release NN cord-007445-2folsh35 148 10 of of IN cord-007445-2folsh35 148 11 histamine histamine NN cord-007445-2folsh35 148 12 , , , cord-007445-2folsh35 148 13 and and CC cord-007445-2folsh35 148 14 also also RB cord-007445-2folsh35 148 15 increased increase VBN cord-007445-2folsh35 148 16 eosino eosino NNP cord-007445-2folsh35 148 17 - - HYPH cord-007445-2folsh35 148 18 phi1 phi1 NN cord-007445-2folsh35 148 19 recruitment recruitment NN cord-007445-2folsh35 148 20 of of IN cord-007445-2folsh35 148 21 eosinophils eosinophil NNS cord-007445-2folsh35 148 22 to to IN cord-007445-2folsh35 148 23 the the DT cord-007445-2folsh35 148 24 lung lung NN cord-007445-2folsh35 148 25 . . . cord-007445-2folsh35 149 1 Respiratory respiratory JJ cord-007445-2folsh35 149 2 infections infection NNS cord-007445-2folsh35 149 3 can can MD cord-007445-2folsh35 149 4 have have VB cord-007445-2folsh35 149 5 dual dual JJ cord-007445-2folsh35 149 6 effects effect NNS cord-007445-2folsh35 149 7 related relate VBN cord-007445-2folsh35 149 8 to to IN cord-007445-2folsh35 149 9 asthma asthma NN cord-007445-2folsh35 149 10 . . . cord-007445-2folsh35 150 1 First first RB cord-007445-2folsh35 150 2 , , , cord-007445-2folsh35 150 3 there there EX cord-007445-2folsh35 150 4 is be VBZ cord-007445-2folsh35 150 5 increasing increase VBG cord-007445-2folsh35 150 6 evidence evidence NN cord-007445-2folsh35 150 7 that that IN cord-007445-2folsh35 150 8 severe severe JJ cord-007445-2folsh35 150 9 infections infection NNS cord-007445-2folsh35 150 10 with with IN cord-007445-2folsh35 150 11 RSV RSV NNP cord-007445-2folsh35 150 12 and and CC cord-007445-2folsh35 150 13 PIV PIV NNP cord-007445-2folsh35 150 14 in in IN cord-007445-2folsh35 150 15 infancy infancy NN cord-007445-2folsh35 150 16 can can MD cord-007445-2folsh35 150 17 alter alter VB cord-007445-2folsh35 150 18 lung lung NN cord-007445-2folsh35 150 19 development development NN cord-007445-2folsh35 150 20 and and CC cord-007445-2folsh35 150 21 physiology physiology NN cord-007445-2folsh35 150 22 to to TO cord-007445-2folsh35 150 23 increase increase VB cord-007445-2folsh35 150 24 the the DT cord-007445-2folsh35 150 25 risks risk NNS cord-007445-2folsh35 150 26 of of IN cord-007445-2folsh35 150 27 subsequent subsequent JJ cord-007445-2folsh35 150 28 wheezing wheezing NN cord-007445-2folsh35 150 29 and and CC cord-007445-2folsh35 150 30 asthma asthma NN cord-007445-2folsh35 150 31 . . . cord-007445-2folsh35 151 1 Second second RB cord-007445-2folsh35 151 2 , , , cord-007445-2folsh35 151 3 infections infection NNS cord-007445-2folsh35 151 4 with with IN cord-007445-2folsh35 151 5 common common JJ cord-007445-2folsh35 151 6 cold cold JJ cord-007445-2folsh35 151 7 viruses virus NNS cord-007445-2folsh35 151 8 and and CC cord-007445-2folsh35 151 9 influenza influenza NN cord-007445-2folsh35 151 10 commonly commonly RB cord-007445-2folsh35 151 11 precipitate precipitate VBP cord-007445-2folsh35 151 12 wheezing wheezing JJ cord-007445-2folsh35 151 13 symptoms symptom NNS cord-007445-2folsh35 151 14 in in IN cord-007445-2folsh35 151 15 children child NNS cord-007445-2folsh35 151 16 and and CC cord-007445-2folsh35 151 17 adults adult NNS cord-007445-2folsh35 151 18 who who WP cord-007445-2folsh35 151 19 already already RB cord-007445-2folsh35 151 20 have have VBP cord-007445-2folsh35 151 21 established establish VBN cord-007445-2folsh35 151 22 asthma asthma NN cord-007445-2folsh35 151 23 , , , cord-007445-2folsh35 151 24 and and CC cord-007445-2folsh35 151 25 RV RV NNP cord-007445-2folsh35 151 26 appears appear VBZ cord-007445-2folsh35 151 27 to to TO cord-007445-2folsh35 151 28 be be VB cord-007445-2folsh35 151 29 the the DT cord-007445-2folsh35 151 30 most most RBS cord-007445-2folsh35 151 31 important important JJ cord-007445-2folsh35 151 32 virus virus NN cord-007445-2folsh35 151 33 in in IN cord-007445-2folsh35 151 34 producing produce VBG cord-007445-2folsh35 151 35 exacerbations exacerbation NNS cord-007445-2folsh35 151 36 of of IN cord-007445-2folsh35 151 37 the the DT cord-007445-2folsh35 151 38 disease disease NN cord-007445-2folsh35 151 39 . . . cord-007445-2folsh35 152 1 The the DT cord-007445-2folsh35 152 2 principal principal JJ cord-007445-2folsh35 152 3 mechanisms mechanism NNS cord-007445-2folsh35 152 4 by by IN cord-007445-2folsh35 152 5 which which WDT cord-007445-2folsh35 152 6 this this DT cord-007445-2folsh35 152 7 occurs occur VBZ cord-007445-2folsh35 152 8 appears appear VBZ cord-007445-2folsh35 152 9 to to TO cord-007445-2folsh35 152 10 be be VB cord-007445-2folsh35 152 11 viral viral JJ cord-007445-2folsh35 152 12 replication replication NN cord-007445-2folsh35 152 13 in in IN cord-007445-2folsh35 152 14 epithelial epithelial JJ cord-007445-2folsh35 152 15 cells cell NNS cord-007445-2folsh35 152 16 , , , cord-007445-2folsh35 152 17 triggering trigger VBG cord-007445-2folsh35 152 18 a a DT cord-007445-2folsh35 152 19 cascade cascade NN cord-007445-2folsh35 152 20 of of IN cord-007445-2folsh35 152 21 inflammation inflammation NN cord-007445-2folsh35 152 22 involving involve VBG cord-007445-2folsh35 152 23 granulocytes granulocyte NNS cord-007445-2folsh35 152 24 , , , cord-007445-2folsh35 152 25 macrophages macrophage NNS cord-007445-2folsh35 152 26 , , , cord-007445-2folsh35 152 27 T t NN cord-007445-2folsh35 152 28 cells cell NNS cord-007445-2folsh35 152 29 , , , cord-007445-2folsh35 152 30 and and CC cord-007445-2folsh35 152 31 secreted secrete VBN cord-007445-2folsh35 152 32 cytokines cytokine NNS cord-007445-2folsh35 152 33 and and CC cord-007445-2folsh35 152 34 mediators mediator NNS cord-007445-2folsh35 152 35 . . . cord-007445-2folsh35 153 1 The the DT cord-007445-2folsh35 153 2 inflammatory inflammatory JJ cord-007445-2folsh35 153 3 process process NN cord-007445-2folsh35 153 4 , , , cord-007445-2folsh35 153 5 although although IN cord-007445-2folsh35 153 6 essential essential JJ cord-007445-2folsh35 153 7 to to TO cord-007445-2folsh35 153 8 clear clear VB cord-007445-2folsh35 153 9 the the DT cord-007445-2folsh35 153 10 infection infection NN cord-007445-2folsh35 153 11 , , , cord-007445-2folsh35 153 12 augments augment VBZ cord-007445-2folsh35 153 13 pre pre JJ cord-007445-2folsh35 153 14 - - JJ cord-007445-2folsh35 153 15 existing existing JJ cord-007445-2folsh35 153 16 airway airway NN cord-007445-2folsh35 153 17 inflammation inflammation NN cord-007445-2folsh35 153 18 in in IN cord-007445-2folsh35 153 19 asthma asthma NN cord-007445-2folsh35 153 20 , , , cord-007445-2folsh35 153 21 leading lead VBG cord-007445-2folsh35 153 22 to to IN cord-007445-2folsh35 153 23 increased increase VBN cord-007445-2folsh35 153 24 airway airway NN cord-007445-2folsh35 153 25 obstruction obstruction NN cord-007445-2folsh35 153 26 and and CC cord-007445-2folsh35 153 27 lower low JJR cord-007445-2folsh35 153 28 respiratory respiratory JJ cord-007445-2folsh35 153 29 tract tract NN cord-007445-2folsh35 153 30 symptoms symptom NNS cord-007445-2folsh35 153 31 . . . cord-007445-2folsh35 154 1 Greater great JJR cord-007445-2folsh35 154 2 understanding understanding NN cord-007445-2folsh35 154 3 of of IN cord-007445-2folsh35 154 4 virus virus NN cord-007445-2folsh35 154 5 - - HYPH cord-007445-2folsh35 154 6 induced induce VBN cord-007445-2folsh35 154 7 changes change NNS cord-007445-2folsh35 154 8 in in IN cord-007445-2folsh35 154 9 inflammation inflammation NN cord-007445-2folsh35 154 10 and and CC cord-007445-2folsh35 154 11 corresponding corresponding JJ cord-007445-2folsh35 154 12 changes change NNS cord-007445-2folsh35 154 13 in in IN cord-007445-2folsh35 154 14 airway airway NN cord-007445-2folsh35 154 15 physiology physiology NN cord-007445-2folsh35 154 16 may may MD cord-007445-2folsh35 154 17 lead lead VB cord-007445-2folsh35 154 18 to to IN cord-007445-2folsh35 154 19 new new JJ cord-007445-2folsh35 154 20 therapeutic therapeutic JJ cord-007445-2folsh35 154 21 approaches approach NNS cord-007445-2folsh35 154 22 to to IN cord-007445-2folsh35 154 23 the the DT cord-007445-2folsh35 154 24 treatment treatment NN cord-007445-2folsh35 154 25 and and CC cord-007445-2folsh35 154 26 prevention prevention NN cord-007445-2folsh35 154 27 of of IN cord-007445-2folsh35 154 28 virus virus NN cord-007445-2folsh35 154 29 - - HYPH cord-007445-2folsh35 154 30 induced induce VBN cord-007445-2folsh35 154 31 airway airway NN cord-007445-2folsh35 154 32 dysfunction dysfunction NN cord-007445-2folsh35 154 33 . . . cord-007445-2folsh35 155 1 Association Association NNP cord-007445-2folsh35 155 2 of of IN cord-007445-2folsh35 155 3 radiologically radiologically RB cord-007445-2folsh35 155 4 ascertained ascertain VBN cord-007445-2folsh35 155 5 pneumonia pneumonia NN cord-007445-2folsh35 155 6 before before IN cord-007445-2folsh35 155 7 age age NN cord-007445-2folsh35 155 8 3 3 CD cord-007445-2folsh35 155 9 years year NNS cord-007445-2folsh35 155 10 with with IN cord-007445-2folsh35 155 11 asthma asthma NN cord-007445-2folsh35 155 12 - - HYPH cord-007445-2folsh35 155 13 like like JJ cord-007445-2folsh35 155 14 symptoms symptom NNS cord-007445-2folsh35 155 15 and and CC cord-007445-2folsh35 155 16 pulmonary pulmonary JJ cord-007445-2folsh35 155 17 function function NN cord-007445-2folsh35 155 18 during during IN cord-007445-2folsh35 155 19 childhood childhood NN cord-007445-2folsh35 155 20 . . . cord-007445-2folsh35 156 1 A a DT cord-007445-2folsh35 156 2 prospective prospective JJ cord-007445-2folsh35 156 3 study study NN cord-007445-2folsh35 156 4 . . . cord-007445-2folsh35 156 5 _SP cord-007445-2folsh35 157 1 Openshaw Openshaw NNP cord-007445-2folsh35 157 2 PJM PJM NNP cord-007445-2folsh35 157 3 Distinct distinct JJ cord-007445-2folsh35 157 4 types type NNS cord-007445-2folsh35 157 5 of of IN cord-007445-2folsh35 157 6 lung lung NN cord-007445-2folsh35 157 7 disease disease NN cord-007445-2folsh35 157 8 caused cause VBN cord-007445-2folsh35 157 9 by by IN cord-007445-2folsh35 157 10 functional functional JJ cord-007445-2folsh35 157 11 subsets subset NNS cord-007445-2folsh35 157 12 of of IN cord-007445-2folsh35 157 13 antiviral antiviral JJ cord-007445-2folsh35 157 14 T t NN cord-007445-2folsh35 157 15 cells cell NNS cord-007445-2folsh35 157 16 Phenotypic phenotypic JJ cord-007445-2folsh35 157 17 and and CC cord-007445-2folsh35 157 18 functional functional JJ cord-007445-2folsh35 157 19 characterization characterization NN cord-007445-2folsh35 157 20 of of IN cord-007445-2folsh35 157 21 T t NN cord-007445-2folsh35 157 22 - - HYPH cord-007445-2folsh35 157 23 cell cell NN cord-007445-2folsh35 157 24 lines line NNS cord-007445-2folsh35 157 25 specific specific JJ cord-007445-2folsh35 157 26 for for IN cord-007445-2folsh35 157 27 individual individual JJ cord-007445-2folsh35 157 28 respiratory respiratory JJ cord-007445-2folsh35 157 29 syncytial syncytial JJ cord-007445-2folsh35 157 30 virus virus NN cord-007445-2folsh35 157 31 proteins protein NNS cord-007445-2folsh35 157 32 Induction Induction NNP cord-007445-2folsh35 157 33 of of IN cord-007445-2folsh35 157 34 human human JJ cord-007445-2folsh35 157 35 airway airway NN cord-007445-2folsh35 158 1 hyperresponsiveness hyperresponsiveness NNP cord-007445-2folsh35 158 2 by by IN cord-007445-2folsh35 158 3 tumour tumour NN cord-007445-2folsh35 158 4 necrosis necrosis NN cord-007445-2folsh35 158 5 factor factor NN cord-007445-2folsh35 158 6 - - : cord-007445-2folsh35 158 7 a a DT cord-007445-2folsh35 158 8 Cytokine cytokine NN cord-007445-2folsh35 158 9 ( ( -LRB- cord-007445-2folsh35 158 10 IL-8 IL-8 NNP cord-007445-2folsh35 158 11 , , , cord-007445-2folsh35 158 12 IL-6 IL-6 NNP cord-007445-2folsh35 158 13 , , , cord-007445-2folsh35 158 14 TNF TNF NNP cord-007445-2folsh35 158 15 - - HYPH cord-007445-2folsh35 158 16 a a NNP cord-007445-2folsh35 158 17 ) ) -RRB- cord-007445-2folsh35 158 18 and and CC cord-007445-2folsh35 158 19 soluble soluble JJ cord-007445-2folsh35 158 20 TNF TNF NNP cord-007445-2folsh35 158 21 receptor receptor NN cord-007445-2folsh35 159 1 -I -i DT cord-007445-2folsh35 159 2 release release NN cord-007445-2folsh35 159 3 from from IN cord-007445-2folsh35 159 4 human human JJ cord-007445-2folsh35 159 5 peripheral peripheral JJ cord-007445-2folsh35 159 6 blood blood NN cord-007445-2folsh35 159 7 mononuclear mononuclear NN cord-007445-2folsh35 159 8 cells cell NNS cord-007445-2folsh35 159 9 after after IN cord-007445-2folsh35 159 10 respiratory respiratory JJ cord-007445-2folsh35 159 11 syncytial syncytial JJ cord-007445-2folsh35 159 12 virus virus NN cord-007445-2folsh35 159 13 infection infection NN cord-007445-2folsh35 159 14 Virusinduced Virusinduced NNP cord-007445-2folsh35 159 15 alterations alteration NNS cord-007445-2folsh35 159 16 in in IN cord-007445-2folsh35 159 17 macrophage macrophage NN cord-007445-2folsh35 159 18 production production NN cord-007445-2folsh35 159 19 of of IN cord-007445-2folsh35 159 20 tumor tumor NN cord-007445-2folsh35 159 21 necrosis necrosis NN cord-007445-2folsh35 159 22 factor factor NN cord-007445-2folsh35 159 23 and and CC cord-007445-2folsh35 159 24 prostaglandin prostaglandin NN cord-007445-2folsh35 159 25 - - HYPH cord-007445-2folsh35 159 26 E2 E2 NNP cord-007445-2folsh35 159 27 Rhinovirus Rhinovirus NNP cord-007445-2folsh35 159 28 infection infection NN cord-007445-2folsh35 159 29 induces induce VBZ cord-007445-2folsh35 159 30 expression expression NN cord-007445-2folsh35 159 31 of of IN cord-007445-2folsh35 159 32 its -PRON- PRP$ cord-007445-2folsh35 159 33 own own JJ cord-007445-2folsh35 159 34 receptor receptor NN cord-007445-2folsh35 159 35 intercellular intercellular JJ cord-007445-2folsh35 159 36 adhesion adhesion NN cord-007445-2folsh35 159 37 molecule molecule NN cord-007445-2folsh35 159 38 1 1 CD cord-007445-2folsh35 159 39 ( ( -LRB- cord-007445-2folsh35 159 40 ICAM-1 ICAM-1 NNP cord-007445-2folsh35 159 41 ) ) -RRB- cord-007445-2folsh35 159 42 via via IN cord-007445-2folsh35 159 43 increased increase VBN cord-007445-2folsh35 159 44 NF NF NNP cord-007445-2folsh35 159 45 - - HYPH cord-007445-2folsh35 159 46 kappaB kappaB NNP cord-007445-2folsh35 159 47 - - HYPH cord-007445-2folsh35 159 48 mediated mediate VBN cord-007445-2folsh35 159 49 transcription transcription NN cord-007445-2folsh35 159 50 Rhinovirusinduced Rhinovirusinduced NNP cord-007445-2folsh35 159 51 peripheral peripheral JJ cord-007445-2folsh35 159 52 blood blood NN cord-007445-2folsh35 159 53 mononuclear mononuclear JJ cord-007445-2folsh35 159 54 cell cell NN cord-007445-2folsh35 159 55 responses response NNS cord-007445-2folsh35 159 56 and and CC cord-007445-2folsh35 159 57 outcome outcome NN cord-007445-2folsh35 159 58 of of IN cord-007445-2folsh35 159 59 experimental experimental JJ cord-007445-2folsh35 159 60 infection infection NN cord-007445-2folsh35 159 61 in in IN cord-007445-2folsh35 159 62 allergic allergic JJ cord-007445-2folsh35 159 63 subjects subject NNS cord-007445-2folsh35 159 64 Interleukin Interleukin NNP cord-007445-2folsh35 159 65 - - HYPH cord-007445-2folsh35 159 66 la la NNP cord-007445-2folsh35 159 67 mediates mediate VBZ cord-007445-2folsh35 159 68 the the DT cord-007445-2folsh35 159 69 enhanced enhanced JJ cord-007445-2folsh35 159 70 expression expression NN cord-007445-2folsh35 159 71 of of IN cord-007445-2folsh35 159 72 intercellular intercellular JJ cord-007445-2folsh35 159 73 adhesion adhesion NN cord-007445-2folsh35 159 74 molecule-1 molecule-1 NN cord-007445-2folsh35 159 75 in in IN cord-007445-2folsh35 159 76 pulmonary pulmonary JJ cord-007445-2folsh35 159 77 epithelial epithelial JJ cord-007445-2folsh35 159 78 cells cell NNS cord-007445-2folsh35 159 79 infected infect VBN cord-007445-2folsh35 159 80 with with IN cord-007445-2folsh35 159 81 respiratory respiratory JJ cord-007445-2folsh35 159 82 syncytial syncytial JJ cord-007445-2folsh35 159 83 virus virus NN cord-007445-2folsh35 159 84 Viruses virus NNS cord-007445-2folsh35 159 85 as as IN cord-007445-2folsh35 159 86 precipitants precipitant NNS cord-007445-2folsh35 159 87 of of IN cord-007445-2folsh35 159 88 asthma asthma NN cord-007445-2folsh35 159 89 symptoms symptom NNS cord-007445-2folsh35 159 90 . . . cord-007445-2folsh35 160 1 I. I. NNP cord-007445-2folsh35 160 2 Epidemiology Epidemiology NNP cord-007445-2folsh35 160 3 Development Development NNP cord-007445-2folsh35 160 4 of of IN cord-007445-2folsh35 160 5 allergen allergen NN cord-007445-2folsh35 160 6 - - HYPH cord-007445-2folsh35 160 7 specific specific JJ cord-007445-2folsh35 160 8 T t NN cord-007445-2folsh35 160 9 - - HYPH cord-007445-2folsh35 160 10 cell cell NN cord-007445-2folsh35 160 11 memory memory NN cord-007445-2folsh35 160 12 in in IN cord-007445-2folsh35 160 13 atopic atopic JJ cord-007445-2folsh35 160 14 and and CC cord-007445-2folsh35 160 15 normal normal JJ cord-007445-2folsh35 160 16 children child NNS cord-007445-2folsh35 161 1 Wheezing wheezing JJ cord-007445-2folsh35 161 2 , , , cord-007445-2folsh35 161 3 asthma asthma NN cord-007445-2folsh35 161 4 , , , cord-007445-2folsh35 161 5 and and CC cord-007445-2folsh35 161 6 pulmonary pulmonary JJ cord-007445-2folsh35 161 7 dysfunction dysfunction NN cord-007445-2folsh35 161 8 10 10 CD cord-007445-2folsh35 161 9 years year NNS cord-007445-2folsh35 161 10 after after IN cord-007445-2folsh35 161 11 infection infection NN cord-007445-2folsh35 161 12 with with IN cord-007445-2folsh35 161 13 respiratory respiratory JJ cord-007445-2folsh35 161 14 syncytial syncytial JJ cord-007445-2folsh35 161 15 virus virus NN cord-007445-2folsh35 161 16 in in IN cord-007445-2folsh35 161 17 infancy infancy NN cord-007445-2folsh35 161 18 Increase increase NN cord-007445-2folsh35 161 19 in in IN cord-007445-2folsh35 161 20 CD23 CD23 NNP cord-007445-2folsh35 161 21 + + CC cord-007445-2folsh35 161 22 cells cell NNS cord-007445-2folsh35 161 23 in in IN cord-007445-2folsh35 161 24 infants infant NNS cord-007445-2folsh35 161 25 with with IN cord-007445-2folsh35 161 26 bronchiolitis bronchiolitis NN cord-007445-2folsh35 161 27 is be VBZ cord-007445-2folsh35 161 28 accompanied accompany VBN cord-007445-2folsh35 161 29 by by IN cord-007445-2folsh35 161 30 appearance appearance NN cord-007445-2folsh35 161 31 of of IN cord-007445-2folsh35 161 32 IgE IgE NNP cord-007445-2folsh35 161 33 and and CC cord-007445-2folsh35 161 34 IgG4 IgG4 NNP cord-007445-2folsh35 161 35 antibodies antibody NNS cord-007445-2folsh35 161 36 specific specific JJ cord-007445-2folsh35 161 37 for for IN cord-007445-2folsh35 161 38 respiratory respiratory JJ cord-007445-2folsh35 161 39 syncytial syncytial JJ cord-007445-2folsh35 161 40 virus virus NN cord-007445-2folsh35 161 41 Rhinovirus rhinovirus NN cord-007445-2folsh35 161 42 and and CC cord-007445-2folsh35 161 43 respiratory respiratory JJ cord-007445-2folsh35 161 44 syncytial syncytial JJ cord-007445-2folsh35 161 45 virus virus NN cord-007445-2folsh35 161 46 in in IN cord-007445-2folsh35 161 47 wheezing wheeze VBG cord-007445-2folsh35 161 48 children child NNS cord-007445-2folsh35 161 49 requiring require VBG cord-007445-2folsh35 161 50 emergency emergency NN cord-007445-2folsh35 161 51 ca ca NNP cord-007445-2folsh35 161 52 - - HYPH cord-007445-2folsh35 161 53 IgE IgE NNP cord-007445-2folsh35 161 54 and and CC cord-007445-2folsh35 161 55 eosinophil eosinophil JJ cord-007445-2folsh35 161 56 analyses analysis NNS cord-007445-2folsh35 162 1 Reduced reduce VBN cord-007445-2folsh35 162 2 interferon interferon NN cord-007445-2folsh35 162 3 - - HYPH cord-007445-2folsh35 162 4 y y NN cord-007445-2folsh35 162 5 production production NN cord-007445-2folsh35 162 6 in in IN cord-007445-2folsh35 162 7 infants infant NNS cord-007445-2folsh35 162 8 with with IN cord-007445-2folsh35 162 9 bronchiolitis bronchiolitis NN cord-007445-2folsh35 162 10 and and CC cord-007445-2folsh35 162 11 asthma asthma NN cord-007445-2folsh35 162 12 Cellular cellular JJ cord-007445-2folsh35 162 13 immunity immunity NN cord-007445-2folsh35 162 14 is be VBZ cord-007445-2folsh35 162 15 activated activate VBN cord-007445-2folsh35 162 16 and and CC cord-007445-2folsh35 162 17 a a DT cord-007445-2folsh35 162 18 TH-2 TH-2 NNP cord-007445-2folsh35 162 19 response response NN cord-007445-2folsh35 162 20 is be VBZ cord-007445-2folsh35 162 21 associated associate VBN cord-007445-2folsh35 162 22 with with IN cord-007445-2folsh35 162 23 early early JJ cord-007445-2folsh35 162 24 wheezing wheezing NN cord-007445-2folsh35 162 25 in in IN cord-007445-2folsh35 162 26 infants infant NNS cord-007445-2folsh35 162 27 after after IN cord-007445-2folsh35 162 28 bronchiolitis bronchiolitis NN cord-007445-2folsh35 162 29 Different different JJ cord-007445-2folsh35 162 30 effects effect NNS cord-007445-2folsh35 162 31 of of IN cord-007445-2folsh35 162 32 influenza influenza NN cord-007445-2folsh35 162 33 virus virus NN cord-007445-2folsh35 162 34 , , , cord-007445-2folsh35 162 35 respiratory respiratory JJ cord-007445-2folsh35 162 36 syncytial syncytial JJ cord-007445-2folsh35 162 37 virus virus NN cord-007445-2folsh35 162 38 , , , cord-007445-2folsh35 162 39 and and CC cord-007445-2folsh35 162 40 sendai sendai NNP cord-007445-2folsh35 162 41 virus virus NN cord-007445-2folsh35 162 42 on on IN cord-007445-2folsh35 162 43 human human JJ cord-007445-2folsh35 162 44 lymphocytes lymphocyte NNS cord-007445-2folsh35 162 45 and and CC cord-007445-2folsh35 162 46 macrophages macrophage NNS cord-007445-2folsh35 162 47 Interleukin-1 Interleukin-1 NNP cord-007445-2folsh35 162 48 and and CC cord-007445-2folsh35 162 49 interleukin-1 interleukin-1 NN cord-007445-2folsh35 162 50 inhibitor inhibitor NN cord-007445-2folsh35 162 51 production production NN cord-007445-2folsh35 162 52 by by IN cord-007445-2folsh35 162 53 human human JJ cord-007445-2folsh35 162 54 macrophages macrophage NNS cord-007445-2folsh35 162 55 exposed expose VBN cord-007445-2folsh35 162 56 to to IN cord-007445-2folsh35 162 57 influenza influenza NN cord-007445-2folsh35 162 58 virus virus NN cord-007445-2folsh35 162 59 or or CC cord-007445-2folsh35 162 60 respiratory respiratory JJ cord-007445-2folsh35 162 61 syncytial syncytial JJ cord-007445-2folsh35 162 62 virus virus NN cord-007445-2folsh35 163 1 The the DT cord-007445-2folsh35 163 2 relationship relationship NN cord-007445-2folsh35 163 3 between between IN cord-007445-2folsh35 163 4 proved prove VBN cord-007445-2folsh35 163 5 viral viral JJ cord-007445-2folsh35 163 6 bronchiolitis bronchiolitis NN cord-007445-2folsh35 163 7 and and CC cord-007445-2folsh35 163 8 subsequent subsequent JJ cord-007445-2folsh35 163 9 wheezing wheeze VBG cord-007445-2folsh35 163 10 Ruuskanen Ruuskanen NNP cord-007445-2folsh35 163 11 0 0 CD cord-007445-2folsh35 163 12 , , , cord-007445-2folsh35 163 13 Ogra Ogra NNP cord-007445-2folsh35 163 14 PL PL NNP cord-007445-2folsh35 163 15 : : : cord-007445-2folsh35 163 16 Respiratory respiratory JJ cord-007445-2folsh35 163 17 syncytial syncytial JJ cord-007445-2folsh35 163 18 virus virus NN cord-007445-2folsh35 163 19 Enhancement enhancement NN cord-007445-2folsh35 163 20 by by IN cord-007445-2folsh35 163 21 parainfluenza parainfluenza NNP cord-007445-2folsh35 163 22 3 3 CD cord-007445-2folsh35 163 23 infection infection NN cord-007445-2folsh35 163 24 of of IN cord-007445-2folsh35 163 25 contractile contractile JJ cord-007445-2folsh35 163 26 responses response NNS cord-007445-2folsh35 163 27 to to IN cord-007445-2folsh35 163 28 substance substance NN cord-007445-2folsh35 163 29 P p NN cord-007445-2folsh35 163 30 and and CC cord-007445-2folsh35 163 31 capsaicin capsaicin NNS cord-007445-2folsh35 163 32 in in IN cord-007445-2folsh35 163 33 airway airway NN cord-007445-2folsh35 163 34 smooth smooth JJ cord-007445-2folsh35 163 35 muscle muscle NN cord-007445-2folsh35 163 36 from from IN cord-007445-2folsh35 163 37 the the DT cord-007445-2folsh35 163 38 guinea guinea NN cord-007445-2folsh35 163 39 pig pig NN cord-007445-2folsh35 163 40 Effect Effect NNP cord-007445-2folsh35 163 41 of of IN cord-007445-2folsh35 163 42 influenza influenza NN cord-007445-2folsh35 163 43 virus virus NN cord-007445-2folsh35 163 44 infection infection NN cord-007445-2folsh35 163 45 on on IN cord-007445-2folsh35 163 46 allergic allergic JJ cord-007445-2folsh35 163 47 sensitization sensitization NN cord-007445-2folsh35 163 48 to to IN cord-007445-2folsh35 163 49 aerosolized aerosolize VBN cord-007445-2folsh35 163 50 ovalbumin ovalbumin NNS cord-007445-2folsh35 163 51 in in IN cord-007445-2folsh35 163 52 mice mouse NNS cord-007445-2folsh35 164 1 Nitric nitric NN cord-007445-2folsh35 164 2 oxide oxide NN cord-007445-2folsh35 164 3 inhibits inhibit VBZ cord-007445-2folsh35 164 4 rhinovirus rhinovirus NN cord-007445-2folsh35 164 5 - - HYPH cord-007445-2folsh35 164 6 induced induce VBN cord-007445-2folsh35 164 7 cytokine cytokine NN cord-007445-2folsh35 164 8 production production NN cord-007445-2folsh35 164 9 and and CC cord-007445-2folsh35 164 10 viral viral JJ cord-007445-2folsh35 164 11 replication replication NN cord-007445-2folsh35 164 12 in in IN cord-007445-2folsh35 164 13 a a DT cord-007445-2folsh35 164 14 human human JJ cord-007445-2folsh35 164 15 respiratory respiratory JJ cord-007445-2folsh35 164 16 epithelial epithelial JJ cord-007445-2folsh35 164 17 cell cell NN cord-007445-2folsh35 164 18 line line NN cord-007445-2folsh35 164 19 Rhinovirus Rhinovirus NNP cord-007445-2folsh35 164 20 replication replication NN cord-007445-2folsh35 164 21 causes cause VBZ cord-007445-2folsh35 164 22 RANTES RANTES NNP cord-007445-2folsh35 164 23 production production NN cord-007445-2folsh35 164 24 in in IN cord-007445-2folsh35 164 25 primary primary JJ cord-007445-2folsh35 164 26 bronchial bronchial JJ cord-007445-2folsh35 164 27 epithelial epithelial JJ cord-007445-2folsh35 164 28 cells cell NNS cord-007445-2folsh35 164 29 Increased increase VBN cord-007445-2folsh35 164 30 levels level NNS cord-007445-2folsh35 164 31 of of IN cord-007445-2folsh35 164 32 eosinophil eosinophil JJ cord-007445-2folsh35 164 33 major major JJ cord-007445-2folsh35 164 34 basic basic JJ cord-007445-2folsh35 164 35 protein protein NN cord-007445-2folsh35 164 36 in in IN cord-007445-2folsh35 164 37 nasal nasal JJ cord-007445-2folsh35 164 38 secretions secretion NNS cord-007445-2folsh35 164 39 in in IN cord-007445-2folsh35 164 40 rhinovirus rhinovirus NN cord-007445-2folsh35 164 41 infection infection NN cord-007445-2folsh35 164 42 [ [ -LRB- cord-007445-2folsh35 164 43 abstract abstract JJ cord-007445-2folsh35 164 44 Respiratory respiratory JJ cord-007445-2folsh35 164 45 syncytial syncytial JJ cord-007445-2folsh35 164 46 virus virus NN cord-007445-2folsh35 164 47 - - HYPH cord-007445-2folsh35 164 48 induced induce VBN cord-007445-2folsh35 164 49 release release NN cord-007445-2folsh35 164 50 of of IN cord-007445-2folsh35 164 51 RANTES RANTES NNPS cord-007445-2folsh35 164 52 and and CC cord-007445-2folsh35 164 53 MIP-1 MIP-1 NNP cord-007445-2folsh35 164 54 by by IN cord-007445-2folsh35 164 55 bronchial bronchial JJ cord-007445-2folsh35 164 56 epithelial epithelial NN cord-007445-2folsh35 164 57 and and CC cord-007445-2folsh35 164 58 peripheral peripheral JJ cord-007445-2folsh35 164 59 mononuclear mononuclear JJ cord-007445-2folsh35 164 60 cells cell NNS cord-007445-2folsh35 164 61 Asthma asthma NN cord-007445-2folsh35 164 62 and and CC cord-007445-2folsh35 164 63 immunoglobulin immunoglobulin NN cord-007445-2folsh35 164 64 - - HYPH cord-007445-2folsh35 164 65 E e NN cord-007445-2folsh35 164 66 antibodies antibody NNS cord-007445-2folsh35 164 67 after after IN cord-007445-2folsh35 164 68 respiratory respiratory JJ cord-007445-2folsh35 164 69 syncytial syncytial JJ cord-007445-2folsh35 164 70 virus virus NN cord-007445-2folsh35 164 71 bronchiolitis bronchiolitis NN cord-007445-2folsh35 164 72 : : : cord-007445-2folsh35 165 1 A a DT cord-007445-2folsh35 165 2 prospective prospective JJ cord-007445-2folsh35 165 3 cohort cohort NN cord-007445-2folsh35 165 4 study study NN cord-007445-2folsh35 165 5 with with IN cord-007445-2folsh35 165 6 matched match VBN cord-007445-2folsh35 165 7 controls control VBZ cord-007445-2folsh35 165 8 Lower low JJR cord-007445-2folsh35 165 9 airway airway NN cord-007445-2folsh35 165 10 responses response NNS cord-007445-2folsh35 165 11 to to TO cord-007445-2folsh35 165 12 influenza influenza VB cord-007445-2folsh35 165 13 A a DT cord-007445-2folsh35 165 14 virus virus NN cord-007445-2folsh35 165 15 in in IN cord-007445-2folsh35 165 16 healthy healthy JJ cord-007445-2folsh35 165 17 allergic allergic JJ cord-007445-2folsh35 165 18 and and CC cord-007445-2folsh35 165 19 nonallergic nonallergic JJ cord-007445-2folsh35 165 20 subjects subject NNS cord-007445-2folsh35 166 1 Virusinduced Virusinduced NNP cord-007445-2folsh35 166 2 airway airway NN cord-007445-2folsh35 166 3 obstruction obstruction NN cord-007445-2folsh35 166 4 and and CC cord-007445-2folsh35 166 5 parasympathetic parasympathetic JJ cord-007445-2folsh35 166 6 hyperresponsiveness hyperresponsiveness NN cord-007445-2folsh35 166 7 in in IN cord-007445-2folsh35 166 8 adult adult NN cord-007445-2folsh35 166 9 rats rat NNS cord-007445-2folsh35 166 10 Prevention Prevention NNP cord-007445-2folsh35 166 11 of of IN cord-007445-2folsh35 166 12 chronic chronic JJ cord-007445-2folsh35 166 13 post post JJ cord-007445-2folsh35 166 14 - - JJ cord-007445-2folsh35 166 15 bronchiolitis bronchiolitis JJ cord-007445-2folsh35 166 16 airway airway NN cord-007445-2folsh35 166 17 sequelae sequela NNS cord-007445-2folsh35 166 18 with with IN cord-007445-2folsh35 166 19 interferon interferon NN cord-007445-2folsh35 166 20 - - HYPH cord-007445-2folsh35 166 21 y y NNP cord-007445-2folsh35 166 22 treatment treatment NN cord-007445-2folsh35 166 23 in in IN cord-007445-2folsh35 166 24 rats rat NNS cord-007445-2folsh35 166 25 A a DT cord-007445-2folsh35 166 26 cell cell NN cord-007445-2folsh35 166 27 adhesion adhesion NN cord-007445-2folsh35 166 28 molecule molecule NN cord-007445-2folsh35 166 29 , , , cord-007445-2folsh35 167 1 ICAM ICAM NNP cord-007445-2folsh35 167 2 - - HYPH cord-007445-2folsh35 167 3 I I NNP cord-007445-2folsh35 167 4 , , , cord-007445-2folsh35 167 5 is be VBZ cord-007445-2folsh35 167 6 the the DT cord-007445-2folsh35 167 7 major major JJ cord-007445-2folsh35 167 8 surface surface NN cord-007445-2folsh35 167 9 receptor receptor NN cord-007445-2folsh35 167 10 for for IN cord-007445-2folsh35 167 11 rhinoviruses rhinovirus NNS cord-007445-2folsh35 167 12 Respiratory respiratory JJ cord-007445-2folsh35 167 13 syncytial syncytial JJ cord-007445-2folsh35 167 14 virus virus NN cord-007445-2folsh35 167 15 in in IN cord-007445-2folsh35 167 16 early early JJ cord-007445-2folsh35 167 17 life life NN cord-007445-2folsh35 167 18 and and CC cord-007445-2folsh35 167 19 risk risk NN cord-007445-2folsh35 167 20 of of IN cord-007445-2folsh35 167 21 wheeze wheeze NN cord-007445-2folsh35 167 22 and and CC cord-007445-2folsh35 167 23 allergy allergy NN cord-007445-2folsh35 167 24 by by IN cord-007445-2folsh35 167 25 age age NN cord-007445-2folsh35 167 26 13 13 CD cord-007445-2folsh35 167 27 years year NNS cord-007445-2folsh35 168 1 Infection infection NN cord-007445-2folsh35 168 2 of of IN cord-007445-2folsh35 168 3 a a DT cord-007445-2folsh35 168 4 human human JJ cord-007445-2folsh35 168 5 respiratory respiratory JJ cord-007445-2folsh35 168 6 epithelial epithelial JJ cord-007445-2folsh35 168 7 cell cell NN cord-007445-2folsh35 168 8 line line NN cord-007445-2folsh35 168 9 with with IN cord-007445-2folsh35 168 10 rhinovirus rhinovirus NN cord-007445-2folsh35 168 11 . . . cord-007445-2folsh35 169 1 Induction induction NN cord-007445-2folsh35 169 2 of of IN cord-007445-2folsh35 169 3 cytokine cytokine NN cord-007445-2folsh35 169 4 release release NN cord-007445-2folsh35 169 5 and and CC cord-007445-2folsh35 169 6 modulation modulation NN cord-007445-2folsh35 169 7 of of IN cord-007445-2folsh35 169 8 susceptibility susceptibility NN cord-007445-2folsh35 169 9 to to IN cord-007445-2folsh35 169 10 infection infection NN cord-007445-2folsh35 169 11 by by IN cord-007445-2folsh35 169 12 cytokine cytokine NN cord-007445-2folsh35 169 13 exposure exposure NN cord-007445-2folsh35 169 14 Respiratory respiratory JJ cord-007445-2folsh35 169 15 syncytial syncytial JJ cord-007445-2folsh35 169 16 virus virus NN cord-007445-2folsh35 169 17 infection infection NN cord-007445-2folsh35 169 18 of of IN cord-007445-2folsh35 169 19 neonatal neonatal JJ cord-007445-2folsh35 169 20 monocytes monocyte NNS cord-007445-2folsh35 169 21 stimulates stimulate VBZ cord-007445-2folsh35 169 22 synthesis synthesis NN cord-007445-2folsh35 169 23 of of IN cord-007445-2folsh35 169 24 interferon interferon NN cord-007445-2folsh35 169 25 regulatory regulatory JJ cord-007445-2folsh35 169 26 factor-1 factor-1 NNP cord-007445-2folsh35 169 27 and and CC cord-007445-2folsh35 169 28 interleukin interleukin NN cord-007445-2folsh35 169 29 - - HYPH cord-007445-2folsh35 169 30 lp lp NN cord-007445-2folsh35 170 1 ( ( -LRB- cord-007445-2folsh35 170 2 IL IL NNP cord-007445-2folsh35 170 3 - - HYPH cord-007445-2folsh35 170 4 lp)-converting lp)-converte VBG cord-007445-2folsh35 170 5 enzyme enzyme NN cord-007445-2folsh35 170 6 and and CC cord-007445-2folsh35 170 7 secretion secretion NN cord-007445-2folsh35 170 8 of of IN cord-007445-2folsh35 170 9 IL-1p IL-1p NNP cord-007445-2folsh35 170 10 Targeted targeted JJ cord-007445-2folsh35 170 11 expression expression NN cord-007445-2folsh35 170 12 of of IN cord-007445-2folsh35 170 13 IL-11 IL-11 NNP cord-007445-2folsh35 170 14 in in IN cord-007445-2folsh35 170 15 the the DT cord-007445-2folsh35 170 16 murine murine JJ cord-007445-2folsh35 170 17 airway airway NN cord-007445-2folsh35 170 18 causes cause NNS cord-007445-2folsh35 170 19 lymphocytic lymphocytic JJ cord-007445-2folsh35 170 20 inflammation inflammation NN cord-007445-2folsh35 170 21 , , , cord-007445-2folsh35 170 22 bronchial bronchial JJ cord-007445-2folsh35 170 23 remodelling remodelling NN cord-007445-2folsh35 170 24 , , , cord-007445-2folsh35 170 25 and and CC cord-007445-2folsh35 170 26 airways airways NNP cord-007445-2folsh35 170 27 obstruction obstruction NN cord-007445-2folsh35 170 28 Role role NN cord-007445-2folsh35 170 29 of of IN cord-007445-2folsh35 170 30 nasal nasal NN cord-007445-2folsh35 170 31 interleukin-8 interleukin-8 NNP cord-007445-2folsh35 170 32 in in IN cord-007445-2folsh35 170 33 neutrophil neutrophil NN cord-007445-2folsh35 170 34 recruitment recruitment NN cord-007445-2folsh35 170 35 and and CC cord-007445-2folsh35 170 36 activation activation NN cord-007445-2folsh35 170 37 in in IN cord-007445-2folsh35 170 38 children child NNS cord-007445-2folsh35 170 39 with with IN cord-007445-2folsh35 170 40 virus virus NN cord-007445-2folsh35 170 41 - - HYPH cord-007445-2folsh35 170 42 induced induce VBN cord-007445-2folsh35 170 43 asthma asthma NN cord-007445-2folsh35 170 44 Respiratory respiratory JJ cord-007445-2folsh35 170 45 syncytial syncytial JJ cord-007445-2folsh35 170 46 virus virus NN cord-007445-2folsh35 170 47 - - HYPH cord-007445-2folsh35 170 48 induced induce VBN cord-007445-2folsh35 170 49 cytokine cytokine NN cord-007445-2folsh35 170 50 production production NN cord-007445-2folsh35 170 51 by by IN cord-007445-2folsh35 170 52 neonatal neonatal JJ cord-007445-2folsh35 170 53 macrophages macrophage NNS cord-007445-2folsh35 170 54 Association Association NNP cord-007445-2folsh35 170 55 between between IN cord-007445-2folsh35 170 56 interleukin-8 interleukin-8 NNP cord-007445-2folsh35 170 57 concentration concentration NN cord-007445-2folsh35 170 58 in in IN cord-007445-2folsh35 170 59 nasal nasal NN cord-007445-2folsh35 170 60 secretions secretion NNS cord-007445-2folsh35 170 61 and and CC cord-007445-2folsh35 170 62 severity severity NN cord-007445-2folsh35 170 63 of of IN cord-007445-2folsh35 170 64 symptoms symptom NNS cord-007445-2folsh35 170 65 of of IN cord-007445-2folsh35 170 66 experimental experimental JJ cord-007445-2folsh35 170 67 rhinovirus rhinovirus NN cord-007445-2folsh35 170 68 colds cold NNS cord-007445-2folsh35 170 69 Parainfluenza Parainfluenza NNP cord-007445-2folsh35 170 70 virus virus NN cord-007445-2folsh35 170 71 - - HYPH cord-007445-2folsh35 170 72 induced induce VBN cord-007445-2folsh35 170 73 persistence persistence NN cord-007445-2folsh35 170 74 of of IN cord-007445-2folsh35 170 75 airway airway JJ cord-007445-2folsh35 170 76 inflammation inflammation NN cord-007445-2folsh35 170 77 , , , cord-007445-2folsh35 170 78 fibrosis fibrosis NN cord-007445-2folsh35 170 79 , , , cord-007445-2folsh35 170 80 and and CC cord-007445-2folsh35 170 81 dysfunction dysfunction NN cord-007445-2folsh35 170 82 associated associate VBN cord-007445-2folsh35 170 83 with with IN cord-007445-2folsh35 170 84 TGF TGF NNP cord-007445-2folsh35 170 85 - - HYPH cord-007445-2folsh35 170 86 PI PI NNP cord-007445-2folsh35 170 87 expression expression NN cord-007445-2folsh35 170 88 in in IN cord-007445-2folsh35 170 89 brown brown JJ cord-007445-2folsh35 170 90 Norway Norway NNP cord-007445-2folsh35 170 91 rats rat VBZ cord-007445-2folsh35 170 92 Antibody Antibody NNP cord-007445-2folsh35 170 93 to to IN cord-007445-2folsh35 170 94 interleukin-5 interleukin-5 NNP cord-007445-2folsh35 170 95 inhibits inhibit VBZ cord-007445-2folsh35 170 96 virus virus NN cord-007445-2folsh35 170 97 - - HYPH cord-007445-2folsh35 170 98 induced induce VBN cord-007445-2folsh35 170 99 airway airway NN cord-007445-2folsh35 170 100 hyperresponsiveness hyperresponsiveness NN cord-007445-2folsh35 170 101 to to IN cord-007445-2folsh35 170 102 histamine histamine NN cord-007445-2folsh35 170 103 in in IN cord-007445-2folsh35 170 104 guinea guinea NN cord-007445-2folsh35 170 105 pigs pig NNS cord-007445-2folsh35 171 1 Jncreased jncreased JJ cord-007445-2folsh35 171 2 production production NN cord-007445-2folsh35 171 3 of of IN cord-007445-2folsh35 171 4 IFN IFN NNP cord-007445-2folsh35 171 5 -- -- : cord-007445-2folsh35 171 6 y y NNP cord-007445-2folsh35 171 7 and and CC cord-007445-2folsh35 171 8 cysteinyl cysteinyl NNP cord-007445-2folsh35 171 9 leukotrienes leukotriene NNS cord-007445-2folsh35 171 10 in in IN cord-007445-2folsh35 171 11 virus virus NN cord-007445-2folsh35 171 12 - - HYPH cord-007445-2folsh35 171 13 induced induce VBN cord-007445-2folsh35 171 14 wheezing wheeze VBG cord-007445-2folsh35 171 15 Respiratory respiratory JJ cord-007445-2folsh35 171 16 syncytial syncytial JJ cord-007445-2folsh35 171 17 virus virus NN cord-007445-2folsh35 171 18 infection infection NN cord-007445-2folsh35 171 19 of of IN cord-007445-2folsh35 171 20 human human JJ cord-007445-2folsh35 171 21 mononuclear mononuclear JJ cord-007445-2folsh35 171 22 phagocytes phagocyte NNS cord-007445-2folsh35 171 23 stimulates stimulate VBZ cord-007445-2folsh35 171 24 synthesis synthesis NN cord-007445-2folsh35 171 25 of of IN cord-007445-2folsh35 171 26 platelet platelet NN cord-007445-2folsh35 171 27 - - HYPH cord-007445-2folsh35 171 28 activating activate VBG cord-007445-2folsh35 171 29 factor factor NN cord-007445-2folsh35 172 1 The the DT cord-007445-2folsh35 172 2 release release NN cord-007445-2folsh35 172 3 of of IN cord-007445-2folsh35 172 4 leukotrienes leukotriene NNS cord-007445-2folsh35 172 5 in in IN cord-007445-2folsh35 172 6 the the DT cord-007445-2folsh35 172 7 respiratory respiratory JJ cord-007445-2folsh35 172 8 tract tract NN cord-007445-2folsh35 172 9 during during IN cord-007445-2folsh35 172 10 infection infection NN cord-007445-2folsh35 172 11 with with IN cord-007445-2folsh35 172 12 respiratory respiratory JJ cord-007445-2folsh35 172 13 syncytial syncytial JJ cord-007445-2folsh35 172 14 virus virus NN cord-007445-2folsh35 172 15 : : : cord-007445-2folsh35 172 16 Role role NN cord-007445-2folsh35 172 17 in in IN cord-007445-2folsh35 172 18 obstructive obstructive JJ cord-007445-2folsh35 172 19 airway airway NN cord-007445-2folsh35 172 20 disease disease NN cord-007445-2folsh35 172 21 Asthma Asthma NNP cord-007445-2folsh35 172 22 , , , cord-007445-2folsh35 172 23 atopy atopy NN cord-007445-2folsh35 172 24 and and CC cord-007445-2folsh35 172 25 Chlamydia Chlamydia NNP cord-007445-2folsh35 172 26 pneumoniae pneumoniae NN cord-007445-2folsh35 172 27 antibodies antibody NNS cord-007445-2folsh35 172 28 in in IN cord-007445-2folsh35 172 29 adults adult NNS cord-007445-2folsh35 172 30 Continuing continue VBG cord-007445-2folsh35 172 31 respiratory respiratory JJ cord-007445-2folsh35 172 32 problems problem NNS cord-007445-2folsh35 172 33 three three CD cord-007445-2folsh35 172 34 and and CC cord-007445-2folsh35 172 35 a a DT cord-007445-2folsh35 172 36 half half NN cord-007445-2folsh35 172 37 years year NNS cord-007445-2folsh35 172 38 after after IN cord-007445-2folsh35 172 39 acute acute JJ cord-007445-2folsh35 172 40 viral viral JJ cord-007445-2folsh35 172 41 bronchiolitis bronchiolitis NN cord-007445-2folsh35 172 42 Immunologic immunologic JJ cord-007445-2folsh35 172 43 mechanisms mechanism NNS cord-007445-2folsh35 172 44 of of IN cord-007445-2folsh35 172 45 virus virus NN cord-007445-2folsh35 172 46 - - HYPH cord-007445-2folsh35 172 47 induced induce VBN cord-007445-2folsh35 172 48 wheezing wheezing NN cord-007445-2folsh35 172 49 and and CC cord-007445-2folsh35 172 50 asthma asthma NN cord-007445-2folsh35 172 51 Predictive predictive JJ cord-007445-2folsh35 172 52 value value NN cord-007445-2folsh35 172 53 of of IN cord-007445-2folsh35 172 54 respiratory respiratory JJ cord-007445-2folsh35 172 55 syncytial syncytial JJ cord-007445-2folsh35 172 56 virus virus NN cord-007445-2folsh35 172 57 - - HYPH cord-007445-2folsh35 172 58 specific specific JJ cord-007445-2folsh35 172 59 IgE IgE NNP cord-007445-2folsh35 172 60 responses response NNS cord-007445-2folsh35 172 61 for for IN cord-007445-2folsh35 172 62 recurrent recurrent JJ cord-007445-2folsh35 172 63 wheezing wheezing JJ cord-007445-2folsh35 172 64 following follow VBG cord-007445-2folsh35 172 65 bronchiolitis bronchiolitis NN cord-007445-2folsh35 173 1 The the DT cord-007445-2folsh35 173 2 development development NN cord-007445-2folsh35 173 3 of of IN cord-007445-2folsh35 173 4 respiratory respiratory JJ cord-007445-2folsh35 173 5 syncytial syncytial JJ cord-007445-2folsh35 173 6 virus virus NN cord-007445-2folsh35 173 7 - - HYPH cord-007445-2folsh35 173 8 specific specific JJ cord-007445-2folsh35 173 9 IgE IgE NNP cord-007445-2folsh35 173 10 and and CC cord-007445-2folsh35 173 11 the the DT cord-007445-2folsh35 173 12 release release NN cord-007445-2folsh35 173 13 of of IN cord-007445-2folsh35 173 14 histamine histamine NN cord-007445-2folsh35 173 15 in in IN cord-007445-2folsh35 173 16 nasopharyngeal nasopharyngeal JJ cord-007445-2folsh35 173 17 secretions secretion NNS cord-007445-2folsh35 173 18 after after IN cord-007445-2folsh35 173 19 infection infection NN cord-007445-2folsh35 173 20 Patterns pattern NNS cord-007445-2folsh35 173 21 of of IN cord-007445-2folsh35 173 22 allergic allergic JJ cord-007445-2folsh35 173 23 respiratory respiratory JJ cord-007445-2folsh35 173 24 disease disease NN cord-007445-2folsh35 173 25 in in IN cord-007445-2folsh35 173 26 children child NNS cord-007445-2folsh35 173 27 with with IN cord-007445-2folsh35 173 28 a a DT cord-007445-2folsh35 173 29 past past JJ cord-007445-2folsh35 173 30 history history NN cord-007445-2folsh35 173 31 of of IN cord-007445-2folsh35 173 32 bronchiolitis bronchiolitis NN