id sid tid token lemma pos cord-005902-5zuij5i3 1 1 key key JJ cord-005902-5zuij5i3 1 2 : : : cord-005902-5zuij5i3 1 3 cord-005902 cord-005902 VB cord-005902-5zuij5i3 1 4 - - HYPH cord-005902-5zuij5i3 1 5 5zuij5i3 5zuij5i3 CD cord-005902-5zuij5i3 1 6 authors author NNS cord-005902-5zuij5i3 1 7 : : : cord-005902-5zuij5i3 1 8 Frank Frank NNP cord-005902-5zuij5i3 1 9 , , , cord-005902-5zuij5i3 1 10 Johannes Johannes NNP cord-005902-5zuij5i3 1 11 ; ; : cord-005902-5zuij5i3 1 12 Barker Barker NNP cord-005902-5zuij5i3 1 13 , , , cord-005902-5zuij5i3 1 14 John John NNP cord-005902-5zuij5i3 1 15 H. H. NNP cord-005902-5zuij5i3 2 1 ; ; : cord-005902-5zuij5i3 2 2 Marzi Marzi NNP cord-005902-5zuij5i3 2 3 , , , cord-005902-5zuij5i3 2 4 Ingo Ingo NNP cord-005902-5zuij5i3 2 5 title title NN cord-005902-5zuij5i3 2 6 : : : cord-005902-5zuij5i3 2 7 Necrotizing necrotize VBG cord-005902-5zuij5i3 2 8 Fasciitis fasciitis NN cord-005902-5zuij5i3 2 9 of of IN cord-005902-5zuij5i3 2 10 the the DT cord-005902-5zuij5i3 2 11 Extremities Extremities NNPS cord-005902-5zuij5i3 2 12 date date NN cord-005902-5zuij5i3 2 13 : : : cord-005902-5zuij5i3 2 14 2008 2008 CD cord-005902-5zuij5i3 2 15 - - SYM cord-005902-5zuij5i3 2 16 05 05 CD cord-005902-5zuij5i3 2 17 - - SYM cord-005902-5zuij5i3 2 18 30 30 CD cord-005902-5zuij5i3 2 19 journal journal NN cord-005902-5zuij5i3 2 20 : : : cord-005902-5zuij5i3 3 1 Eur Eur NNP cord-005902-5zuij5i3 3 2 J J NNP cord-005902-5zuij5i3 3 3 Trauma Trauma NNP cord-005902-5zuij5i3 3 4 Emerg Emerg NNP cord-005902-5zuij5i3 3 5 Surg Surg NNP cord-005902-5zuij5i3 3 6 DOI DOI NNP cord-005902-5zuij5i3 3 7 : : : cord-005902-5zuij5i3 3 8 10.1007 10.1007 CD cord-005902-5zuij5i3 3 9 / / SYM cord-005902-5zuij5i3 3 10 s00068 s00068 CD cord-005902-5zuij5i3 3 11 - - HYPH cord-005902-5zuij5i3 3 12 008 008 CD cord-005902-5zuij5i3 3 13 - - HYPH cord-005902-5zuij5i3 3 14 8074 8074 CD cord-005902-5zuij5i3 3 15 - - SYM cord-005902-5zuij5i3 3 16 0 0 CD cord-005902-5zuij5i3 3 17 sha sha NN cord-005902-5zuij5i3 3 18 : : : cord-005902-5zuij5i3 3 19 e8d89e643ab0cb706c19fa4ef625f43ca6b8ff46 e8d89e643ab0cb706c19fa4ef625f43ca6b8ff46 NNS cord-005902-5zuij5i3 3 20 doc_id doc_id CD cord-005902-5zuij5i3 3 21 : : : cord-005902-5zuij5i3 3 22 5902 5902 CD cord-005902-5zuij5i3 3 23 cord_uid cord_uid NNS cord-005902-5zuij5i3 3 24 : : : cord-005902-5zuij5i3 4 1 5zuij5i3 5zuij5i3 CD cord-005902-5zuij5i3 4 2 Necrotizing necrotize VBG cord-005902-5zuij5i3 4 3 fasciitis fasciitis NN cord-005902-5zuij5i3 4 4 ( ( -LRB- cord-005902-5zuij5i3 4 5 NF NF NNP cord-005902-5zuij5i3 4 6 ) ) -RRB- cord-005902-5zuij5i3 4 7 describes describe VBZ cord-005902-5zuij5i3 4 8 a a DT cord-005902-5zuij5i3 4 9 life life NN cord-005902-5zuij5i3 4 10 threatening threaten VBG cord-005902-5zuij5i3 4 11 soft soft JJ cord-005902-5zuij5i3 4 12 tissue tissue NN cord-005902-5zuij5i3 4 13 infection infection NN cord-005902-5zuij5i3 4 14 characterized characterize VBN cord-005902-5zuij5i3 4 15 by by IN cord-005902-5zuij5i3 4 16 a a DT cord-005902-5zuij5i3 4 17 rapid rapid JJ cord-005902-5zuij5i3 4 18 spreading spread VBG cord-005902-5zuij5i3 4 19 infection infection NN cord-005902-5zuij5i3 4 20 of of IN cord-005902-5zuij5i3 4 21 the the DT cord-005902-5zuij5i3 4 22 subcutaneous subcutaneous JJ cord-005902-5zuij5i3 4 23 tissue tissue NN cord-005902-5zuij5i3 4 24 and and CC cord-005902-5zuij5i3 4 25 in in IN cord-005902-5zuij5i3 4 26 particular particular JJ cord-005902-5zuij5i3 4 27 the the DT cord-005902-5zuij5i3 4 28 fascia fascia NN cord-005902-5zuij5i3 4 29 . . . cord-005902-5zuij5i3 5 1 Various various JJ cord-005902-5zuij5i3 5 2 synonyms synonyms NN cord-005902-5zuij5i3 5 3 for for IN cord-005902-5zuij5i3 5 4 this this DT cord-005902-5zuij5i3 5 5 type type NN cord-005902-5zuij5i3 5 6 of of IN cord-005902-5zuij5i3 5 7 infection infection NN cord-005902-5zuij5i3 5 8 are be VBP cord-005902-5zuij5i3 5 9 used use VBN cord-005902-5zuij5i3 5 10 , , , cord-005902-5zuij5i3 5 11 often often RB cord-005902-5zuij5i3 5 12 due due IN cord-005902-5zuij5i3 5 13 to to IN cord-005902-5zuij5i3 5 14 the the DT cord-005902-5zuij5i3 5 15 difficult difficult JJ cord-005902-5zuij5i3 5 16 diagnosis diagnosis NN cord-005902-5zuij5i3 5 17 . . . cord-005902-5zuij5i3 6 1 Necrotizing necrotize VBG cord-005902-5zuij5i3 6 2 fasciits fasciit NNS cord-005902-5zuij5i3 6 3 of of IN cord-005902-5zuij5i3 6 4 the the DT cord-005902-5zuij5i3 6 5 extremities extremity NNS cord-005902-5zuij5i3 6 6 is be VBZ cord-005902-5zuij5i3 6 7 found find VBN cord-005902-5zuij5i3 6 8 after after IN cord-005902-5zuij5i3 6 9 simple simple JJ cord-005902-5zuij5i3 6 10 skin skin NN cord-005902-5zuij5i3 6 11 lacerations laceration NNS cord-005902-5zuij5i3 6 12 and and CC cord-005902-5zuij5i3 6 13 often often RB cord-005902-5zuij5i3 6 14 in in IN cord-005902-5zuij5i3 6 15 rural rural JJ cord-005902-5zuij5i3 6 16 , , , cord-005902-5zuij5i3 6 17 farming farming NN cord-005902-5zuij5i3 6 18 or or CC cord-005902-5zuij5i3 6 19 garden garden NN cord-005902-5zuij5i3 6 20 setting setting NN cord-005902-5zuij5i3 6 21 environments environment NNS cord-005902-5zuij5i3 6 22 . . . cord-005902-5zuij5i3 7 1 Many many JJ cord-005902-5zuij5i3 7 2 of of IN cord-005902-5zuij5i3 7 3 the the DT cord-005902-5zuij5i3 7 4 infections infection NNS cord-005902-5zuij5i3 7 5 are be VBP cord-005902-5zuij5i3 7 6 found find VBN cord-005902-5zuij5i3 7 7 in in IN cord-005902-5zuij5i3 7 8 immunologically immunologically RB cord-005902-5zuij5i3 7 9 healthy healthy JJ cord-005902-5zuij5i3 7 10 people people NNS cord-005902-5zuij5i3 7 11 , , , cord-005902-5zuij5i3 7 12 but but CC cord-005902-5zuij5i3 7 13 persons person NNS cord-005902-5zuij5i3 7 14 revealing reveal VBG cord-005902-5zuij5i3 7 15 a a DT cord-005902-5zuij5i3 7 16 compromised compromised JJ cord-005902-5zuij5i3 7 17 wound wound NN cord-005902-5zuij5i3 7 18 healing healing NN cord-005902-5zuij5i3 7 19 are be VBP cord-005902-5zuij5i3 7 20 endangered endanger VBN cord-005902-5zuij5i3 7 21 additionally additionally RB cord-005902-5zuij5i3 7 22 , , , cord-005902-5zuij5i3 7 23 e.g. e.g. RB cord-005902-5zuij5i3 7 24 , , , cord-005902-5zuij5i3 7 25 diabetes diabetes NN cord-005902-5zuij5i3 7 26 . . . cord-005902-5zuij5i3 8 1 In in IN cord-005902-5zuij5i3 8 2 the the DT cord-005902-5zuij5i3 8 3 majority majority NN cord-005902-5zuij5i3 8 4 of of IN cord-005902-5zuij5i3 8 5 the the DT cord-005902-5zuij5i3 8 6 microbiological microbiological JJ cord-005902-5zuij5i3 8 7 analyses analysis NNS cord-005902-5zuij5i3 8 8 , , , cord-005902-5zuij5i3 8 9 streptococci streptococcus NNS cord-005902-5zuij5i3 8 10 alone alone RB cord-005902-5zuij5i3 8 11 or or CC cord-005902-5zuij5i3 8 12 a a DT cord-005902-5zuij5i3 8 13 mixture mixture NN cord-005902-5zuij5i3 8 14 with with IN cord-005902-5zuij5i3 8 15 mainly mainly RB cord-005902-5zuij5i3 8 16 anaerobic anaerobic JJ cord-005902-5zuij5i3 8 17 bacteria bacteria NNS cord-005902-5zuij5i3 8 18 may may MD cord-005902-5zuij5i3 8 19 be be VB cord-005902-5zuij5i3 8 20 detected detect VBN cord-005902-5zuij5i3 8 21 . . . cord-005902-5zuij5i3 9 1 The the DT cord-005902-5zuij5i3 9 2 management management NN cord-005902-5zuij5i3 9 3 of of IN cord-005902-5zuij5i3 9 4 infected infected JJ cord-005902-5zuij5i3 9 5 extremities extremity NNS cord-005902-5zuij5i3 9 6 requires require VBZ cord-005902-5zuij5i3 9 7 a a DT cord-005902-5zuij5i3 9 8 rapid rapid JJ cord-005902-5zuij5i3 9 9 diagnosis diagnosis NN cord-005902-5zuij5i3 9 10 , , , cord-005902-5zuij5i3 9 11 dedicated dedicated JJ cord-005902-5zuij5i3 9 12 aggressive aggressive JJ cord-005902-5zuij5i3 9 13 surgical surgical JJ cord-005902-5zuij5i3 9 14 management management NN cord-005902-5zuij5i3 9 15 as as RB cord-005902-5zuij5i3 9 16 soon soon RB cord-005902-5zuij5i3 9 17 as as IN cord-005902-5zuij5i3 9 18 possible possible JJ cord-005902-5zuij5i3 9 19 , , , cord-005902-5zuij5i3 9 20 and and CC cord-005902-5zuij5i3 9 21 a a DT cord-005902-5zuij5i3 9 22 wide wide JJ cord-005902-5zuij5i3 9 23 debridement debridement NN cord-005902-5zuij5i3 9 24 extending extend VBG cord-005902-5zuij5i3 9 25 the the DT cord-005902-5zuij5i3 9 26 border border NN cord-005902-5zuij5i3 9 27 of of IN cord-005902-5zuij5i3 9 28 the the DT cord-005902-5zuij5i3 9 29 infected infected JJ cord-005902-5zuij5i3 9 30 fascia fascia NN cord-005902-5zuij5i3 9 31 . . . cord-005902-5zuij5i3 10 1 Timely timely JJ cord-005902-5zuij5i3 10 2 surgical surgical JJ cord-005902-5zuij5i3 10 3 revisions revision NNS cord-005902-5zuij5i3 10 4 within within IN cord-005902-5zuij5i3 10 5 the the DT cord-005902-5zuij5i3 10 6 first first JJ cord-005902-5zuij5i3 10 7 day day NN cord-005902-5zuij5i3 10 8 or or CC cord-005902-5zuij5i3 10 9 days day NNS cord-005902-5zuij5i3 10 10 together together RB cord-005902-5zuij5i3 10 11 with with IN cord-005902-5zuij5i3 10 12 antibiotic antibiotic JJ cord-005902-5zuij5i3 10 13 treatment treatment NN cord-005902-5zuij5i3 10 14 are be VBP cord-005902-5zuij5i3 10 15 the the DT cord-005902-5zuij5i3 10 16 only only JJ cord-005902-5zuij5i3 10 17 measures measure NNS cord-005902-5zuij5i3 10 18 to to TO cord-005902-5zuij5i3 10 19 stop stop VB cord-005902-5zuij5i3 10 20 the the DT cord-005902-5zuij5i3 10 21 infection infection NN cord-005902-5zuij5i3 10 22 . . . cord-005902-5zuij5i3 11 1 Depending depend VBG cord-005902-5zuij5i3 11 2 on on IN cord-005902-5zuij5i3 11 3 the the DT cord-005902-5zuij5i3 11 4 status status NN cord-005902-5zuij5i3 11 5 of of IN cord-005902-5zuij5i3 11 6 the the DT cord-005902-5zuij5i3 11 7 patient patient NN cord-005902-5zuij5i3 11 8 a a DT cord-005902-5zuij5i3 11 9 hyperbaric hyperbaric NN cord-005902-5zuij5i3 11 10 oxygenation oxygenation NN cord-005902-5zuij5i3 11 11 treatment treatment NN cord-005902-5zuij5i3 11 12 seems seem VBZ cord-005902-5zuij5i3 11 13 to to TO cord-005902-5zuij5i3 11 14 be be VB cord-005902-5zuij5i3 11 15 useful useful JJ cord-005902-5zuij5i3 11 16 in in IN cord-005902-5zuij5i3 11 17 order order NN cord-005902-5zuij5i3 11 18 to to TO cord-005902-5zuij5i3 11 19 limit limit VB cord-005902-5zuij5i3 11 20 the the DT cord-005902-5zuij5i3 11 21 infection infection NN cord-005902-5zuij5i3 11 22 . . . cord-005902-5zuij5i3 12 1 In in IN cord-005902-5zuij5i3 12 2 fulminated fulminate VBN cord-005902-5zuij5i3 12 3 cases case NNS cord-005902-5zuij5i3 12 4 early early JJ cord-005902-5zuij5i3 12 5 amputations amputation NNS cord-005902-5zuij5i3 12 6 , , , cord-005902-5zuij5i3 12 7 maximal maximal JJ cord-005902-5zuij5i3 12 8 intensive intensive JJ cord-005902-5zuij5i3 12 9 care care NN cord-005902-5zuij5i3 12 10 treatment treatment NN cord-005902-5zuij5i3 12 11 of of IN cord-005902-5zuij5i3 12 12 the the DT cord-005902-5zuij5i3 12 13 septic septic JJ cord-005902-5zuij5i3 12 14 patient patient NN cord-005902-5zuij5i3 12 15 are be VBP cord-005902-5zuij5i3 12 16 required require VBN cord-005902-5zuij5i3 12 17 , , , cord-005902-5zuij5i3 12 18 where where WRB cord-005902-5zuij5i3 12 19 all all DT cord-005902-5zuij5i3 12 20 means mean NNS cord-005902-5zuij5i3 12 21 are be VBP cord-005902-5zuij5i3 12 22 warranted warrant VBN cord-005902-5zuij5i3 12 23 to to TO cord-005902-5zuij5i3 12 24 save save VB cord-005902-5zuij5i3 12 25 the the DT cord-005902-5zuij5i3 12 26 patients patient NNS cord-005902-5zuij5i3 12 27 life life NN cord-005902-5zuij5i3 12 28 . . . cord-005902-5zuij5i3 13 1 As as IN cord-005902-5zuij5i3 13 2 a a DT cord-005902-5zuij5i3 13 3 consequence consequence NN cord-005902-5zuij5i3 13 4 , , , cord-005902-5zuij5i3 13 5 early early JJ cord-005902-5zuij5i3 13 6 clinical clinical JJ cord-005902-5zuij5i3 13 7 diagnoses diagnosis NNS cord-005902-5zuij5i3 13 8 with with IN cord-005902-5zuij5i3 13 9 thorough thorough JJ cord-005902-5zuij5i3 13 10 surgical surgical JJ cord-005902-5zuij5i3 13 11 debridement debridement NN cord-005902-5zuij5i3 13 12 of of IN cord-005902-5zuij5i3 13 13 the the DT cord-005902-5zuij5i3 13 14 infected infect VBN cord-005902-5zuij5i3 13 15 liquid liquid JJ cord-005902-5zuij5i3 13 16 necrotic necrotic JJ cord-005902-5zuij5i3 13 17 fascia fascia NN cord-005902-5zuij5i3 13 18 as as RB cord-005902-5zuij5i3 13 19 well well RB cord-005902-5zuij5i3 13 20 as as IN cord-005902-5zuij5i3 13 21 correct correct JJ cord-005902-5zuij5i3 13 22 antibiotic antibiotic JJ cord-005902-5zuij5i3 13 23 treatment treatment NN cord-005902-5zuij5i3 13 24 are be VBP cord-005902-5zuij5i3 13 25 needed need VBN cord-005902-5zuij5i3 13 26 . . . cord-005902-5zuij5i3 14 1 Secondary secondary JJ cord-005902-5zuij5i3 14 2 plastic plastic NN cord-005902-5zuij5i3 14 3 reconstruction reconstruction NN cord-005902-5zuij5i3 14 4 of of IN cord-005902-5zuij5i3 14 5 the the DT cord-005902-5zuij5i3 14 6 soft soft JJ cord-005902-5zuij5i3 14 7 tissue tissue NN cord-005902-5zuij5i3 14 8 defects defect NNS cord-005902-5zuij5i3 14 9 will will MD cord-005902-5zuij5i3 14 10 generally generally RB cord-005902-5zuij5i3 14 11 be be VB cord-005902-5zuij5i3 14 12 required require VBN cord-005902-5zuij5i3 14 13 . . . cord-005902-5zuij5i3 15 1 Necrotizing necrotize VBG cord-005902-5zuij5i3 15 2 fasciitis fasciitis NN cord-005902-5zuij5i3 15 3 ( ( -LRB- cord-005902-5zuij5i3 15 4 NF NF NNP cord-005902-5zuij5i3 15 5 ) ) -RRB- cord-005902-5zuij5i3 15 6 is be VBZ cord-005902-5zuij5i3 15 7 an an DT cord-005902-5zuij5i3 15 8 infection infection NN cord-005902-5zuij5i3 15 9 accompanied accompany VBN cord-005902-5zuij5i3 15 10 by by IN cord-005902-5zuij5i3 15 11 spreading spread VBG cord-005902-5zuij5i3 15 12 crepitating crepitate VBG cord-005902-5zuij5i3 15 13 edema edema NN cord-005902-5zuij5i3 15 14 and and CC cord-005902-5zuij5i3 15 15 blister blister NN cord-005902-5zuij5i3 15 16 formation formation NN cord-005902-5zuij5i3 15 17 . . . cord-005902-5zuij5i3 16 1 It -PRON- PRP cord-005902-5zuij5i3 16 2 was be VBD cord-005902-5zuij5i3 16 3 first first RB cord-005902-5zuij5i3 16 4 described describe VBN cord-005902-5zuij5i3 16 5 by by IN cord-005902-5zuij5i3 16 6 Hippocrates Hippocrates NNPS cord-005902-5zuij5i3 16 7 in in IN cord-005902-5zuij5i3 16 8 the the DT cord-005902-5zuij5i3 16 9 fifth fifth JJ cord-005902-5zuij5i3 16 10 century century NN cord-005902-5zuij5i3 16 11 as as IN cord-005902-5zuij5i3 16 12 erysipelas erysipelas NNP cord-005902-5zuij5i3 16 13 [ [ -LRB- cord-005902-5zuij5i3 16 14 1 1 CD cord-005902-5zuij5i3 16 15 ] ] -RRB- cord-005902-5zuij5i3 16 16 . . . cord-005902-5zuij5i3 17 1 In in IN cord-005902-5zuij5i3 17 2 the the DT cord-005902-5zuij5i3 17 3 eighteenth eighteenth JJ cord-005902-5zuij5i3 17 4 century century NN cord-005902-5zuij5i3 17 5 a a DT cord-005902-5zuij5i3 17 6 detailed detailed JJ cord-005902-5zuij5i3 17 7 description description NN cord-005902-5zuij5i3 17 8 of of IN cord-005902-5zuij5i3 17 9 NF NF NNP cord-005902-5zuij5i3 17 10 was be VBD cord-005902-5zuij5i3 17 11 provided provide VBN cord-005902-5zuij5i3 17 12 by by IN cord-005902-5zuij5i3 17 13 British british JJ cord-005902-5zuij5i3 17 14 naval naval JJ cord-005902-5zuij5i3 17 15 physicians physician NNS cord-005902-5zuij5i3 17 16 and and CC cord-005902-5zuij5i3 17 17 in in IN cord-005902-5zuij5i3 17 18 the the DT cord-005902-5zuij5i3 17 19 early early JJ cord-005902-5zuij5i3 17 20 nineteenth nineteenth JJ cord-005902-5zuij5i3 17 21 century century NN cord-005902-5zuij5i3 17 22 , , , cord-005902-5zuij5i3 17 23 it -PRON- PRP cord-005902-5zuij5i3 17 24 was be VBD cord-005902-5zuij5i3 17 25 named name VBN cord-005902-5zuij5i3 17 26 as as IN cord-005902-5zuij5i3 17 27 gangrenous gangrenous JJ cord-005902-5zuij5i3 17 28 ulcer ulcer NN cord-005902-5zuij5i3 17 29 , , , cord-005902-5zuij5i3 17 30 putrid putrid JJ cord-005902-5zuij5i3 17 31 ulcer ulcer NN cord-005902-5zuij5i3 17 32 , , , cord-005902-5zuij5i3 17 33 malignant malignant JJ cord-005902-5zuij5i3 17 34 ulcer ulcer NN cord-005902-5zuij5i3 17 35 , , , cord-005902-5zuij5i3 17 36 phagedenic phagedenic JJ cord-005902-5zuij5i3 17 37 ulcer ulcer NN cord-005902-5zuij5i3 17 38 , , , cord-005902-5zuij5i3 17 39 phagedena phagedena NNP cord-005902-5zuij5i3 17 40 , , , cord-005902-5zuij5i3 17 41 and and CC cord-005902-5zuij5i3 17 42 phagedena phagedena NNP cord-005902-5zuij5i3 17 43 gangrenosa gangrenosa NNP cord-005902-5zuij5i3 17 44 and and CC cord-005902-5zuij5i3 17 45 hospital hospital NN cord-005902-5zuij5i3 17 46 gangrene gangrene NN cord-005902-5zuij5i3 17 47 [ [ -LRB- cord-005902-5zuij5i3 17 48 2 2 CD cord-005902-5zuij5i3 17 49 ] ] -RRB- cord-005902-5zuij5i3 17 50 . . . cord-005902-5zuij5i3 18 1 In in IN cord-005902-5zuij5i3 18 2 1871 1871 CD cord-005902-5zuij5i3 18 3 , , , cord-005902-5zuij5i3 18 4 during during IN cord-005902-5zuij5i3 18 5 the the DT cord-005902-5zuij5i3 18 6 civil civil JJ cord-005902-5zuij5i3 18 7 war war NN cord-005902-5zuij5i3 18 8 , , , cord-005902-5zuij5i3 18 9 J. J. NNP cord-005902-5zuij5i3 18 10 Jones Jones NNP cord-005902-5zuij5i3 18 11 , , , cord-005902-5zuij5i3 18 12 an an DT cord-005902-5zuij5i3 18 13 American American NNP cord-005902-5zuij5i3 18 14 Surgeon Surgeon NNP cord-005902-5zuij5i3 18 15 , , , cord-005902-5zuij5i3 18 16 mentioned mention VBD cord-005902-5zuij5i3 18 17 more more JJR cord-005902-5zuij5i3 18 18 than than IN cord-005902-5zuij5i3 18 19 2,000 2,000 CD cord-005902-5zuij5i3 18 20 cases case NNS cord-005902-5zuij5i3 18 21 very very RB cord-005902-5zuij5i3 18 22 possible possible JJ cord-005902-5zuij5i3 18 23 NF nf NN cord-005902-5zuij5i3 18 24 . . . cord-005902-5zuij5i3 19 1 Afterwards afterwards RB cord-005902-5zuij5i3 19 2 Pfanner Pfanner NNP cord-005902-5zuij5i3 19 3 described describe VBD cord-005902-5zuij5i3 19 4 in in IN cord-005902-5zuij5i3 19 5 1818 1818 CD cord-005902-5zuij5i3 19 6 in in IN cord-005902-5zuij5i3 19 7 the the DT cord-005902-5zuij5i3 19 8 German german JJ cord-005902-5zuij5i3 19 9 medical medical JJ cord-005902-5zuij5i3 19 10 literature literature NN cord-005902-5zuij5i3 19 11 the the DT cord-005902-5zuij5i3 19 12 clinical clinical JJ cord-005902-5zuij5i3 19 13 picture picture NN cord-005902-5zuij5i3 19 14 of of IN cord-005902-5zuij5i3 19 15 necrotizing necrotize VBG cord-005902-5zuij5i3 19 16 erysipelas erysipela NNS cord-005902-5zuij5i3 19 17 and and CC cord-005902-5zuij5i3 19 18 found find VBD cord-005902-5zuij5i3 19 19 streptococci streptococcus NNS cord-005902-5zuij5i3 19 20 related relate VBN cord-005902-5zuij5i3 19 21 to to IN cord-005902-5zuij5i3 19 22 the the DT cord-005902-5zuij5i3 19 23 disease disease NN cord-005902-5zuij5i3 19 24 [ [ -LRB- cord-005902-5zuij5i3 19 25 3 3 CD cord-005902-5zuij5i3 19 26 , , , cord-005902-5zuij5i3 19 27 4 4 CD cord-005902-5zuij5i3 19 28 ] ] -RRB- cord-005902-5zuij5i3 19 29 . . . cord-005902-5zuij5i3 20 1 In in IN cord-005902-5zuij5i3 20 2 1924 1924 CD cord-005902-5zuij5i3 20 3 , , , cord-005902-5zuij5i3 20 4 Meleney Meleney NNP cord-005902-5zuij5i3 20 5 used use VBD cord-005902-5zuij5i3 20 6 the the DT cord-005902-5zuij5i3 20 7 name name NN cord-005902-5zuij5i3 20 8 hemolytic hemolytic JJ cord-005902-5zuij5i3 20 9 streptococcal streptococcal JJ cord-005902-5zuij5i3 20 10 gangrene gangrene NN cord-005902-5zuij5i3 20 11 [ [ -LRB- cord-005902-5zuij5i3 20 12 5 5 CD cord-005902-5zuij5i3 20 13 ] ] -RRB- cord-005902-5zuij5i3 20 14 . . . cord-005902-5zuij5i3 21 1 Since since IN cord-005902-5zuij5i3 21 2 then then RB cord-005902-5zuij5i3 21 3 , , , cord-005902-5zuij5i3 21 4 various various JJ cord-005902-5zuij5i3 21 5 names name NNS cord-005902-5zuij5i3 21 6 have have VBP cord-005902-5zuij5i3 21 7 been be VBN cord-005902-5zuij5i3 21 8 given give VBN cord-005902-5zuij5i3 21 9 to to IN cord-005902-5zuij5i3 21 10 NF NF NNP cord-005902-5zuij5i3 21 11 ( ( -LRB- cord-005902-5zuij5i3 21 12 Table table NN cord-005902-5zuij5i3 21 13 1 1 CD cord-005902-5zuij5i3 21 14 ) ) -RRB- cord-005902-5zuij5i3 21 15 . . . cord-005902-5zuij5i3 22 1 Finally finally RB cord-005902-5zuij5i3 22 2 , , , cord-005902-5zuij5i3 22 3 in in IN cord-005902-5zuij5i3 22 4 1952 1952 CD cord-005902-5zuij5i3 22 5 , , , cord-005902-5zuij5i3 22 6 Wilson Wilson NNP cord-005902-5zuij5i3 22 7 used use VBD cord-005902-5zuij5i3 22 8 the the DT cord-005902-5zuij5i3 22 9 term term NN cord-005902-5zuij5i3 22 10 necrotizing necrotize VBG cord-005902-5zuij5i3 22 11 fasciitis fasciitis NN cord-005902-5zuij5i3 22 12 ( ( -LRB- cord-005902-5zuij5i3 22 13 NF nf NN cord-005902-5zuij5i3 22 14 ) ) -RRB- cord-005902-5zuij5i3 22 15 . . . cord-005902-5zuij5i3 23 1 The the DT cord-005902-5zuij5i3 23 2 anogenital anogenital JJ cord-005902-5zuij5i3 23 3 manifestation manifestation NN cord-005902-5zuij5i3 23 4 of of IN cord-005902-5zuij5i3 23 5 NF NF NNP cord-005902-5zuij5i3 23 6 was be VBD cord-005902-5zuij5i3 23 7 first first RB cord-005902-5zuij5i3 23 8 described describe VBN cord-005902-5zuij5i3 23 9 by by IN cord-005902-5zuij5i3 23 10 Fournier Fournier NNP cord-005902-5zuij5i3 23 11 in in IN cord-005902-5zuij5i3 23 12 1883 1883 CD cord-005902-5zuij5i3 23 13 and and CC cord-005902-5zuij5i3 23 14 is be VBZ cord-005902-5zuij5i3 23 15 since since IN cord-005902-5zuij5i3 23 16 then then RB cord-005902-5zuij5i3 23 17 called call VBN cord-005902-5zuij5i3 23 18 Fournier Fournier NNP cord-005902-5zuij5i3 23 19 's 's POS cord-005902-5zuij5i3 23 20 Gangrene Gangrene NNP cord-005902-5zuij5i3 23 21 [ [ -LRB- cord-005902-5zuij5i3 23 22 6 6 CD cord-005902-5zuij5i3 23 23 , , , cord-005902-5zuij5i3 23 24 7 7 CD cord-005902-5zuij5i3 23 25 ] ] -RRB- cord-005902-5zuij5i3 23 26 . . . cord-005902-5zuij5i3 24 1 The the DT cord-005902-5zuij5i3 24 2 early early JJ cord-005902-5zuij5i3 24 3 onset onset NN cord-005902-5zuij5i3 24 4 of of IN cord-005902-5zuij5i3 24 5 this this DT cord-005902-5zuij5i3 24 6 type type NN cord-005902-5zuij5i3 24 7 of of IN cord-005902-5zuij5i3 24 8 soft soft JJ cord-005902-5zuij5i3 24 9 tissue tissue NN cord-005902-5zuij5i3 24 10 infection infection NN cord-005902-5zuij5i3 24 11 is be VBZ cord-005902-5zuij5i3 24 12 a a DT cord-005902-5zuij5i3 24 13 discrepancy discrepancy NN cord-005902-5zuij5i3 24 14 between between IN cord-005902-5zuij5i3 24 15 pronounced pronounced JJ cord-005902-5zuij5i3 24 16 pain pain NN cord-005902-5zuij5i3 24 17 and and CC cord-005902-5zuij5i3 24 18 clinical clinical JJ cord-005902-5zuij5i3 24 19 appearance appearance NN cord-005902-5zuij5i3 24 20 . . . cord-005902-5zuij5i3 25 1 The the DT cord-005902-5zuij5i3 25 2 aggressive aggressive JJ cord-005902-5zuij5i3 25 3 progression progression NN cord-005902-5zuij5i3 25 4 induces induce VBZ cord-005902-5zuij5i3 25 5 finally finally RB cord-005902-5zuij5i3 25 6 skin skin NN cord-005902-5zuij5i3 25 7 and and CC cord-005902-5zuij5i3 25 8 fascia fascia NN cord-005902-5zuij5i3 25 9 necrosis necrosis NN cord-005902-5zuij5i3 25 10 , , , cord-005902-5zuij5i3 25 11 coagulopathia coagulopathia NNP cord-005902-5zuij5i3 25 12 and and CC cord-005902-5zuij5i3 25 13 cellulites cellulite NNS cord-005902-5zuij5i3 25 14 . . . cord-005902-5zuij5i3 26 1 Five five CD cord-005902-5zuij5i3 26 2 diagnostic diagnostic JJ cord-005902-5zuij5i3 26 3 criteria criterion NNS cord-005902-5zuij5i3 26 4 can can MD cord-005902-5zuij5i3 26 5 be be VB cord-005902-5zuij5i3 26 6 defined define VBN cord-005902-5zuij5i3 26 7 ( ( -LRB- cord-005902-5zuij5i3 26 8 Table table NN cord-005902-5zuij5i3 26 9 2 2 CD cord-005902-5zuij5i3 26 10 , , , cord-005902-5zuij5i3 26 11 [ [ -LRB- cord-005902-5zuij5i3 26 12 8 8 CD cord-005902-5zuij5i3 26 13 ] ] -RRB- cord-005902-5zuij5i3 26 14 ) ) -RRB- cord-005902-5zuij5i3 26 15 . . . cord-005902-5zuij5i3 27 1 The the DT cord-005902-5zuij5i3 27 2 missing miss VBG cord-005902-5zuij5i3 27 3 isolation isolation NN cord-005902-5zuij5i3 27 4 of of IN cord-005902-5zuij5i3 27 5 clostridium clostridium NN cord-005902-5zuij5i3 27 6 perfringens perfringens NN cord-005902-5zuij5i3 27 7 does do VBZ cord-005902-5zuij5i3 27 8 not not RB cord-005902-5zuij5i3 27 9 necessarily necessarily RB cord-005902-5zuij5i3 27 10 exclude exclude VB cord-005902-5zuij5i3 27 11 gas gas NN cord-005902-5zuij5i3 27 12 gangrene gangrene NN cord-005902-5zuij5i3 27 13 nor nor CC cord-005902-5zuij5i3 27 14 prove prove VB cord-005902-5zuij5i3 27 15 NF NF NNP cord-005902-5zuij5i3 27 16 . . . cord-005902-5zuij5i3 28 1 In in IN cord-005902-5zuij5i3 28 2 patients patient NNS cord-005902-5zuij5i3 28 3 suffering suffer VBG cord-005902-5zuij5i3 28 4 from from IN cord-005902-5zuij5i3 28 5 NF nf NN cord-005902-5zuij5i3 28 6 , , , cord-005902-5zuij5i3 28 7 more more RBR cord-005902-5zuij5i3 28 8 often often RB cord-005902-5zuij5i3 28 9 diabetes diabete NNS cord-005902-5zuij5i3 28 10 , , , cord-005902-5zuij5i3 28 11 hypertonic hypertonic JJ cord-005902-5zuij5i3 28 12 blood blood NN cord-005902-5zuij5i3 28 13 pressure pressure NN cord-005902-5zuij5i3 28 14 , , , cord-005902-5zuij5i3 28 15 arterial arterial JJ cord-005902-5zuij5i3 28 16 occlusive occlusive JJ cord-005902-5zuij5i3 28 17 disease disease NN cord-005902-5zuij5i3 28 18 , , , cord-005902-5zuij5i3 28 19 and and CC cord-005902-5zuij5i3 28 20 obesity obesity NN cord-005902-5zuij5i3 28 21 are be VBP cord-005902-5zuij5i3 28 22 found find VBN cord-005902-5zuij5i3 28 23 as as RB cord-005902-5zuij5i3 28 24 well well RB cord-005902-5zuij5i3 28 25 as as IN cord-005902-5zuij5i3 28 26 higher high JJR cord-005902-5zuij5i3 28 27 percentage percentage NN cord-005902-5zuij5i3 28 28 of of IN cord-005902-5zuij5i3 28 29 alcohol alcohol NN cord-005902-5zuij5i3 28 30 and and CC cord-005902-5zuij5i3 28 31 drug drug NN cord-005902-5zuij5i3 28 32 abuse abuse NN cord-005902-5zuij5i3 28 33 , , , cord-005902-5zuij5i3 28 34 immunosuppressant immunosuppressant JJ cord-005902-5zuij5i3 28 35 therapy therapy NN cord-005902-5zuij5i3 28 36 and and CC cord-005902-5zuij5i3 28 37 HIVinfections hivinfection NNS cord-005902-5zuij5i3 28 38 . . . cord-005902-5zuij5i3 29 1 Even even RB cord-005902-5zuij5i3 29 2 a a DT cord-005902-5zuij5i3 29 3 varicella varicella NN cord-005902-5zuij5i3 29 4 zoster zoster NN cord-005902-5zuij5i3 29 5 virus virus NN cord-005902-5zuij5i3 29 6 infection infection NN cord-005902-5zuij5i3 29 7 in in IN cord-005902-5zuij5i3 29 8 combination combination NN cord-005902-5zuij5i3 29 9 with with IN cord-005902-5zuij5i3 29 10 the the DT cord-005902-5zuij5i3 29 11 use use NN cord-005902-5zuij5i3 29 12 of of IN cord-005902-5zuij5i3 29 13 NSAIDs NSAIDs NNP cord-005902-5zuij5i3 29 14 is be VBZ cord-005902-5zuij5i3 29 15 discussed discuss VBN cord-005902-5zuij5i3 29 16 as as IN cord-005902-5zuij5i3 29 17 risk risk NN cord-005902-5zuij5i3 29 18 factor factor NN cord-005902-5zuij5i3 29 19 [ [ -LRB- cord-005902-5zuij5i3 29 20 9 9 CD cord-005902-5zuij5i3 29 21 ] ] -RRB- cord-005902-5zuij5i3 29 22 . . . cord-005902-5zuij5i3 30 1 It -PRON- PRP cord-005902-5zuij5i3 30 2 is be VBZ cord-005902-5zuij5i3 30 3 more more RBR cord-005902-5zuij5i3 30 4 likely likely JJ cord-005902-5zuij5i3 30 5 to to TO cord-005902-5zuij5i3 30 6 appear appear VB cord-005902-5zuij5i3 30 7 in in IN cord-005902-5zuij5i3 30 8 elderly elderly JJ cord-005902-5zuij5i3 30 9 people people NNS cord-005902-5zuij5i3 30 10 , , , cord-005902-5zuij5i3 30 11 but but CC cord-005902-5zuij5i3 30 12 children child NNS cord-005902-5zuij5i3 30 13 also also RB cord-005902-5zuij5i3 30 14 can can MD cord-005902-5zuij5i3 30 15 be be VB cord-005902-5zuij5i3 30 16 affected affect VBN cord-005902-5zuij5i3 30 17 . . . cord-005902-5zuij5i3 31 1 In in IN cord-005902-5zuij5i3 31 2 the the DT cord-005902-5zuij5i3 31 3 literature literature NN cord-005902-5zuij5i3 31 4 various various JJ cord-005902-5zuij5i3 31 5 reasons reason NNS cord-005902-5zuij5i3 31 6 have have VBP cord-005902-5zuij5i3 31 7 been be VBN cord-005902-5zuij5i3 31 8 related relate VBN cord-005902-5zuij5i3 31 9 to to IN cord-005902-5zuij5i3 31 10 the the DT cord-005902-5zuij5i3 31 11 primary primary JJ cord-005902-5zuij5i3 31 12 focus focus NN cord-005902-5zuij5i3 31 13 and and CC cord-005902-5zuij5i3 31 14 include include VBP cord-005902-5zuij5i3 31 15 minor minor JJ cord-005902-5zuij5i3 31 16 skin skin NN cord-005902-5zuij5i3 31 17 lesions lesion NNS cord-005902-5zuij5i3 31 18 , , , cord-005902-5zuij5i3 31 19 bites bite NNS cord-005902-5zuij5i3 31 20 of of IN cord-005902-5zuij5i3 31 21 insects insect NNS cord-005902-5zuij5i3 31 22 and and CC cord-005902-5zuij5i3 31 23 wounds wound NNS cord-005902-5zuij5i3 31 24 after after IN cord-005902-5zuij5i3 31 25 surgical surgical JJ cord-005902-5zuij5i3 31 26 procedures procedure NNS cord-005902-5zuij5i3 31 27 [ [ -LRB- cord-005902-5zuij5i3 31 28 10 10 CD cord-005902-5zuij5i3 31 29 ] ] -RRB- cord-005902-5zuij5i3 31 30 . . . cord-005902-5zuij5i3 32 1 Initial initial JJ cord-005902-5zuij5i3 32 2 microbiological microbiological JJ cord-005902-5zuij5i3 32 3 tests test NNS cord-005902-5zuij5i3 32 4 discover discover VBP cord-005902-5zuij5i3 32 5 in in IN cord-005902-5zuij5i3 32 6 a a DT cord-005902-5zuij5i3 32 7 high high JJ cord-005902-5zuij5i3 32 8 amount amount NN cord-005902-5zuij5i3 32 9 streptococci streptococcus NNS cord-005902-5zuij5i3 32 10 ( ( -LRB- cord-005902-5zuij5i3 32 11 app app NN cord-005902-5zuij5i3 32 12 . . . cord-005902-5zuij5i3 33 1 30 30 CD cord-005902-5zuij5i3 33 2 % % NN cord-005902-5zuij5i3 33 3 ) ) -RRB- cord-005902-5zuij5i3 33 4 , , , cord-005902-5zuij5i3 33 5 a a DT cord-005902-5zuij5i3 33 6 mixture mixture NN cord-005902-5zuij5i3 33 7 of of IN cord-005902-5zuij5i3 33 8 different different JJ cord-005902-5zuij5i3 33 9 bacteria bacteria NNS cord-005902-5zuij5i3 33 10 and and CC cord-005902-5zuij5i3 33 11 less less JJR cord-005902-5zuij5i3 33 12 common common JJ cord-005902-5zuij5i3 33 13 pseudomonas pseudomonas NN cord-005902-5zuij5i3 33 14 aeruginosa aeruginosa NN cord-005902-5zuij5i3 33 15 ( ( -LRB- cord-005902-5zuij5i3 33 16 app app NN cord-005902-5zuij5i3 33 17 . . . cord-005902-5zuij5i3 34 1 5 5 CD cord-005902-5zuij5i3 34 2 % % NN cord-005902-5zuij5i3 34 3 , , , cord-005902-5zuij5i3 34 4 Table Table NNP cord-005902-5zuij5i3 34 5 3 3 CD cord-005902-5zuij5i3 34 6 ) ) -RRB- cord-005902-5zuij5i3 34 7 . . . cord-005902-5zuij5i3 35 1 Due due IN cord-005902-5zuij5i3 35 2 to to IN cord-005902-5zuij5i3 35 3 an an DT cord-005902-5zuij5i3 35 4 increased increase VBN cord-005902-5zuij5i3 35 5 amount amount NN cord-005902-5zuij5i3 35 6 of of IN cord-005902-5zuij5i3 35 7 invasive invasive JJ cord-005902-5zuij5i3 35 8 streptococcal streptococcal JJ cord-005902-5zuij5i3 35 9 infections infection NNS cord-005902-5zuij5i3 35 10 in in IN cord-005902-5zuij5i3 35 11 the the DT cord-005902-5zuij5i3 35 12 US US NNP cord-005902-5zuij5i3 35 13 during during IN cord-005902-5zuij5i3 35 14 the the DT cord-005902-5zuij5i3 35 15 1980s 1980 NNS cord-005902-5zuij5i3 35 16 , , , cord-005902-5zuij5i3 35 17 a a DT cord-005902-5zuij5i3 35 18 ' ' `` cord-005902-5zuij5i3 35 19 ' ' `` cord-005902-5zuij5i3 35 20 streptococcal streptococcal JJ cord-005902-5zuij5i3 35 21 septic septic JJ cord-005902-5zuij5i3 35 22 shock shock NN cord-005902-5zuij5i3 35 23 syndrome syndrome NN cord-005902-5zuij5i3 35 24 ( ( -LRB- cord-005902-5zuij5i3 35 25 STSS STSS NNP cord-005902-5zuij5i3 35 26 ) ) -RRB- cord-005902-5zuij5i3 35 27 ' ' '' cord-005902-5zuij5i3 35 28 ' ' '' cord-005902-5zuij5i3 35 29 was be VBD cord-005902-5zuij5i3 35 30 defined define VBN cord-005902-5zuij5i3 35 31 . . . cord-005902-5zuij5i3 36 1 This this DT cord-005902-5zuij5i3 36 2 is be VBZ cord-005902-5zuij5i3 36 3 characterized characterize VBN cord-005902-5zuij5i3 36 4 by by IN cord-005902-5zuij5i3 36 5 a a DT cord-005902-5zuij5i3 36 6 systemic systemic JJ cord-005902-5zuij5i3 36 7 sepsis sepsis NN cord-005902-5zuij5i3 36 8 with with IN cord-005902-5zuij5i3 36 9 multiple multiple JJ cord-005902-5zuij5i3 36 10 organ organ NN cord-005902-5zuij5i3 36 11 failure failure NN cord-005902-5zuij5i3 36 12 , , , cord-005902-5zuij5i3 36 13 especially especially RB cord-005902-5zuij5i3 36 14 the the DT cord-005902-5zuij5i3 36 15 kidney kidney NN cord-005902-5zuij5i3 36 16 . . . cord-005902-5zuij5i3 37 1 Today today NN cord-005902-5zuij5i3 37 2 , , , cord-005902-5zuij5i3 37 3 NF NF NNP cord-005902-5zuij5i3 37 4 caused cause VBN cord-005902-5zuij5i3 37 5 by by IN cord-005902-5zuij5i3 37 6 streptococci streptococcus NNS cord-005902-5zuij5i3 37 7 group group NN cord-005902-5zuij5i3 37 8 A A NNP cord-005902-5zuij5i3 37 9 is be VBZ cord-005902-5zuij5i3 37 10 classified classify VBN cord-005902-5zuij5i3 37 11 as as IN cord-005902-5zuij5i3 37 12 a a DT cord-005902-5zuij5i3 37 13 subgroup subgroup NN cord-005902-5zuij5i3 37 14 of of IN cord-005902-5zuij5i3 37 15 this this DT cord-005902-5zuij5i3 37 16 infection infection NN cord-005902-5zuij5i3 37 17 . . . cord-005902-5zuij5i3 38 1 Also also RB cord-005902-5zuij5i3 38 2 myositis myositis NN cord-005902-5zuij5i3 38 3 caused cause VBN cord-005902-5zuij5i3 38 4 by by IN cord-005902-5zuij5i3 38 5 streptococcimostly streptococcimostly RB cord-005902-5zuij5i3 38 6 due due JJ cord-005902-5zuij5i3 38 7 to to IN cord-005902-5zuij5i3 38 8 direct direct JJ cord-005902-5zuij5i3 38 9 inoculation inoculation NN cord-005902-5zuij5i3 38 10 / / SYM cord-005902-5zuij5i3 38 11 contaminationshould contaminationshould MD cord-005902-5zuij5i3 38 12 be be VB cord-005902-5zuij5i3 38 13 differentiated differentiate VBN cord-005902-5zuij5i3 38 14 . . . cord-005902-5zuij5i3 39 1 In in IN cord-005902-5zuij5i3 39 2 such such JJ cord-005902-5zuij5i3 39 3 cases case NNS cord-005902-5zuij5i3 39 4 rapid rapid JJ cord-005902-5zuij5i3 39 5 lyses lysis NNS cord-005902-5zuij5i3 39 6 of of IN cord-005902-5zuij5i3 39 7 the the DT cord-005902-5zuij5i3 39 8 involved involve VBN cord-005902-5zuij5i3 39 9 muscle muscle NN cord-005902-5zuij5i3 39 10 , , , cord-005902-5zuij5i3 39 11 with with IN cord-005902-5zuij5i3 39 12 edema edema NN cord-005902-5zuij5i3 39 13 formation formation NN cord-005902-5zuij5i3 39 14 , , , cord-005902-5zuij5i3 39 15 focal focal JJ cord-005902-5zuij5i3 39 16 development development NN cord-005902-5zuij5i3 39 17 of of IN cord-005902-5zuij5i3 39 18 a a DT cord-005902-5zuij5i3 39 19 compartment compartment NN cord-005902-5zuij5i3 39 20 syndrome syndrome NN cord-005902-5zuij5i3 39 21 with with IN cord-005902-5zuij5i3 39 22 consecutive consecutive JJ cord-005902-5zuij5i3 39 23 necrosis necrosis NN cord-005902-5zuij5i3 39 24 is be VBZ cord-005902-5zuij5i3 39 25 observed observe VBN cord-005902-5zuij5i3 39 26 [ [ -LRB- cord-005902-5zuij5i3 39 27 11 11 CD cord-005902-5zuij5i3 39 28 ] ] -RRB- cord-005902-5zuij5i3 39 29 [ [ -LRB- cord-005902-5zuij5i3 39 30 12 12 CD cord-005902-5zuij5i3 39 31 ] ] -RRB- cord-005902-5zuij5i3 39 32 [ [ -LRB- cord-005902-5zuij5i3 39 33 13 13 CD cord-005902-5zuij5i3 39 34 ] ] -RRB- cord-005902-5zuij5i3 40 1 [ [ -LRB- cord-005902-5zuij5i3 40 2 14 14 CD cord-005902-5zuij5i3 40 3 ] ] -RRB- cord-005902-5zuij5i3 40 4 [ [ -LRB- cord-005902-5zuij5i3 40 5 15 15 CD cord-005902-5zuij5i3 40 6 ] ] -RRB- cord-005902-5zuij5i3 40 7 [ [ -LRB- cord-005902-5zuij5i3 40 8 16 16 CD cord-005902-5zuij5i3 40 9 ] ] -RRB- cord-005902-5zuij5i3 40 10 . . . cord-005902-5zuij5i3 41 1 Therefore therefore RB cord-005902-5zuij5i3 41 2 necrotizing necrotize VBG cord-005902-5zuij5i3 41 3 soft soft JJ cord-005902-5zuij5i3 41 4 tissue tissue NN cord-005902-5zuij5i3 41 5 infections infection NNS cord-005902-5zuij5i3 41 6 ( ( -LRB- cord-005902-5zuij5i3 41 7 NSTI NSTI NNP cord-005902-5zuij5i3 41 8 's 's POS cord-005902-5zuij5i3 41 9 ) ) -RRB- cord-005902-5zuij5i3 41 10 characterize characterize VBP cord-005902-5zuij5i3 41 11 various various JJ cord-005902-5zuij5i3 41 12 diseases disease NNS cord-005902-5zuij5i3 41 13 . . . cord-005902-5zuij5i3 42 1 Clinically clinically RB cord-005902-5zuij5i3 42 2 they -PRON- PRP cord-005902-5zuij5i3 42 3 can can MD cord-005902-5zuij5i3 42 4 be be VB cord-005902-5zuij5i3 42 5 separated separate VBN cord-005902-5zuij5i3 42 6 in in IN cord-005902-5zuij5i3 42 7 superficial superficial JJ cord-005902-5zuij5i3 42 8 infections infection NNS cord-005902-5zuij5i3 42 9 involving involve VBG cord-005902-5zuij5i3 42 10 cutis cutis NN cord-005902-5zuij5i3 42 11 / / SYM cord-005902-5zuij5i3 42 12 subcutis subcutis NN cord-005902-5zuij5i3 42 13 and and CC cord-005902-5zuij5i3 42 14 deep deep JJ cord-005902-5zuij5i3 42 15 infections infection NNS cord-005902-5zuij5i3 42 16 affecting affect VBG cord-005902-5zuij5i3 42 17 fascia fascia NN cord-005902-5zuij5i3 42 18 and and CC cord-005902-5zuij5i3 42 19 muscle muscle NN cord-005902-5zuij5i3 42 20 ( ( -LRB- cord-005902-5zuij5i3 42 21 NF nf NN cord-005902-5zuij5i3 42 22 , , , cord-005902-5zuij5i3 42 23 myositis myositis NN cord-005902-5zuij5i3 42 24 ) ) -RRB- cord-005902-5zuij5i3 42 25 . . . cord-005902-5zuij5i3 43 1 These these DT cord-005902-5zuij5i3 43 2 deep deep JJ cord-005902-5zuij5i3 43 3 infections infection NNS cord-005902-5zuij5i3 43 4 are be VBP cord-005902-5zuij5i3 43 5 further further RB cord-005902-5zuij5i3 43 6 classified classify VBN cord-005902-5zuij5i3 43 7 as as IN cord-005902-5zuij5i3 43 8 type type NN cord-005902-5zuij5i3 43 9 I -PRON- PRP cord-005902-5zuij5i3 43 10 ( ( -LRB- cord-005902-5zuij5i3 43 11 polymicrobial polymicrobial NNP cord-005902-5zuij5i3 43 12 ) ) -RRB- cord-005902-5zuij5i3 43 13 and and CC cord-005902-5zuij5i3 43 14 type type NN cord-005902-5zuij5i3 43 15 II II NNP cord-005902-5zuij5i3 43 16 ( ( -LRB- cord-005902-5zuij5i3 43 17 monomicrobial monomicrobial NNP cord-005902-5zuij5i3 43 18 ) ) -RRB- cord-005902-5zuij5i3 43 19 . . . cord-005902-5zuij5i3 44 1 Bacterial bacterial JJ cord-005902-5zuij5i3 44 2 factors factor NNS cord-005902-5zuij5i3 44 3 play play VBP cord-005902-5zuij5i3 44 4 an an DT cord-005902-5zuij5i3 44 5 important important JJ cord-005902-5zuij5i3 44 6 role role NN cord-005902-5zuij5i3 44 7 in in IN cord-005902-5zuij5i3 44 8 NSTI NSTI NNP cord-005902-5zuij5i3 44 9 . . . cord-005902-5zuij5i3 45 1 In in IN cord-005902-5zuij5i3 45 2 the the DT cord-005902-5zuij5i3 45 3 cases case NNS cord-005902-5zuij5i3 45 4 of of IN cord-005902-5zuij5i3 45 5 invasive invasive JJ cord-005902-5zuij5i3 45 6 streptococcal streptococcal JJ cord-005902-5zuij5i3 45 7 infections infection NNS cord-005902-5zuij5i3 45 8 , , , cord-005902-5zuij5i3 45 9 surface surface NN cord-005902-5zuij5i3 45 10 proteins protein NNS cord-005902-5zuij5i3 45 11 ( ( -LRB- cord-005902-5zuij5i3 45 12 M1 M1 NNP cord-005902-5zuij5i3 45 13 , , , cord-005902-5zuij5i3 45 14 M3 M3 NNP cord-005902-5zuij5i3 45 15 ) ) -RRB- cord-005902-5zuij5i3 45 16 increase increase VBP cord-005902-5zuij5i3 45 17 adhesion adhesion NN cord-005902-5zuij5i3 45 18 and and CC cord-005902-5zuij5i3 45 19 prevent prevent VB cord-005902-5zuij5i3 45 20 phagocytosis phagocytosis NN cord-005902-5zuij5i3 45 21 and and CC cord-005902-5zuij5i3 45 22 exotoxines exotoxine NNS cord-005902-5zuij5i3 45 23 ( ( -LRB- cord-005902-5zuij5i3 45 24 A A NNP cord-005902-5zuij5i3 45 25 , , , cord-005902-5zuij5i3 45 26 B B NNP cord-005902-5zuij5i3 45 27 , , , cord-005902-5zuij5i3 45 28 C C NNP cord-005902-5zuij5i3 45 29 , , , cord-005902-5zuij5i3 45 30 streptococci streptococcus NNS cord-005902-5zuij5i3 45 31 super super JJ cord-005902-5zuij5i3 45 32 - - JJ cord-005902-5zuij5i3 45 33 antigen antigen JJ cord-005902-5zuij5i3 45 34 ) ) -RRB- cord-005902-5zuij5i3 45 35 induce induce VB cord-005902-5zuij5i3 45 36 the the DT cord-005902-5zuij5i3 45 37 release release NN cord-005902-5zuij5i3 45 38 of of IN cord-005902-5zuij5i3 45 39 cytokines cytokine NNS cord-005902-5zuij5i3 45 40 and and CC cord-005902-5zuij5i3 45 41 could could MD cord-005902-5zuij5i3 45 42 bind bind VB cord-005902-5zuij5i3 45 43 to to IN cord-005902-5zuij5i3 45 44 T t NN cord-005902-5zuij5i3 45 45 - - HYPH cord-005902-5zuij5i3 45 46 cell cell NN cord-005902-5zuij5i3 45 47 receptors receptor NNS cord-005902-5zuij5i3 45 48 causing cause VBG cord-005902-5zuij5i3 45 49 further further JJ cord-005902-5zuij5i3 45 50 release release NN cord-005902-5zuij5i3 45 51 of of IN cord-005902-5zuij5i3 45 52 TNF TNF NNP cord-005902-5zuij5i3 45 53 - - : cord-005902-5zuij5i3 45 54 a a NNP cord-005902-5zuij5i3 45 55 , , , cord-005902-5zuij5i3 45 56 IL-1 IL-1 NNP cord-005902-5zuij5i3 45 57 and and CC cord-005902-5zuij5i3 45 58 IL-6 IL-6 NNP cord-005902-5zuij5i3 45 59 ending end VBG cord-005902-5zuij5i3 45 60 in in IN cord-005902-5zuij5i3 45 61 a a DT cord-005902-5zuij5i3 45 62 STSS STSS NNP cord-005902-5zuij5i3 45 63 [ [ -LRB- cord-005902-5zuij5i3 45 64 17 17 CD cord-005902-5zuij5i3 45 65 , , , cord-005902-5zuij5i3 45 66 18 18 CD cord-005902-5zuij5i3 45 67 ] ] -RRB- cord-005902-5zuij5i3 45 68 . . . cord-005902-5zuij5i3 46 1 Although although IN cord-005902-5zuij5i3 46 2 M M NNP cord-005902-5zuij5i3 46 3 - - HYPH cord-005902-5zuij5i3 46 4 types type NNS cord-005902-5zuij5i3 46 5 1 1 CD cord-005902-5zuij5i3 46 6 and and CC cord-005902-5zuij5i3 46 7 3 3 CD cord-005902-5zuij5i3 46 8 are be VBP cord-005902-5zuij5i3 46 9 common common JJ cord-005902-5zuij5i3 46 10 other other JJ cord-005902-5zuij5i3 46 11 types type NNS cord-005902-5zuij5i3 46 12 have have VBP cord-005902-5zuij5i3 46 13 been be VBN cord-005902-5zuij5i3 46 14 isolated isolate VBN cord-005902-5zuij5i3 46 15 in in IN cord-005902-5zuij5i3 46 16 invasive invasive JJ cord-005902-5zuij5i3 46 17 infections infection NNS cord-005902-5zuij5i3 46 18 ; ; : cord-005902-5zuij5i3 46 19 however however RB cord-005902-5zuij5i3 46 20 , , , cord-005902-5zuij5i3 46 21 a a DT cord-005902-5zuij5i3 46 22 stable stable JJ cord-005902-5zuij5i3 46 23 genetic genetic JJ cord-005902-5zuij5i3 46 24 change change NN cord-005902-5zuij5i3 46 25 was be VBD cord-005902-5zuij5i3 46 26 observed observe VBN cord-005902-5zuij5i3 46 27 in in IN cord-005902-5zuij5i3 46 28 M M NNP cord-005902-5zuij5i3 46 29 - - HYPH cord-005902-5zuij5i3 46 30 type type NNP cord-005902-5zuij5i3 46 31 1 1 CD cord-005902-5zuij5i3 46 32 group group NN cord-005902-5zuij5i3 46 33 A a DT cord-005902-5zuij5i3 46 34 streptococci streptococcus NNS cord-005902-5zuij5i3 46 35 in in IN cord-005902-5zuij5i3 46 36 the the DT cord-005902-5zuij5i3 46 37 1980s 1980 NNS cord-005902-5zuij5i3 46 38 , , , cord-005902-5zuij5i3 46 39 resulting result VBG cord-005902-5zuij5i3 46 40 in in IN cord-005902-5zuij5i3 46 41 its -PRON- PRP$ cord-005902-5zuij5i3 46 42 ability ability NN cord-005902-5zuij5i3 46 43 to to TO cord-005902-5zuij5i3 46 44 produce produce VB cord-005902-5zuij5i3 46 45 nicotinamide nicotinamide NN cord-005902-5zuij5i3 46 46 adenine adenine NN cord-005902-5zuij5i3 46 47 dinucleotide dinucleotide NN cord-005902-5zuij5i3 46 48 glycohydrolase glycohydrolase NN cord-005902-5zuij5i3 46 49 ( ( -LRB- cord-005902-5zuij5i3 46 50 NADase NADase NNP cord-005902-5zuij5i3 46 51 ) ) -RRB- cord-005902-5zuij5i3 46 52 and and CC cord-005902-5zuij5i3 46 53 might may MD cord-005902-5zuij5i3 46 54 be be VB cord-005902-5zuij5i3 46 55 one one CD cord-005902-5zuij5i3 46 56 factor factor NN cord-005902-5zuij5i3 46 57 in in IN cord-005902-5zuij5i3 46 58 severe severe JJ cord-005902-5zuij5i3 46 59 invasive invasive JJ cord-005902-5zuij5i3 46 60 infections infection NNS cord-005902-5zuij5i3 46 61 [ [ -LRB- cord-005902-5zuij5i3 46 62 19 19 CD cord-005902-5zuij5i3 46 63 ] ] -RRB- cord-005902-5zuij5i3 46 64 . . . cord-005902-5zuij5i3 47 1 The the DT cord-005902-5zuij5i3 47 2 rapid rapid JJ cord-005902-5zuij5i3 47 3 tissue tissue NN cord-005902-5zuij5i3 47 4 destruction destruction NN cord-005902-5zuij5i3 47 5 is be VBZ cord-005902-5zuij5i3 47 6 a a DT cord-005902-5zuij5i3 47 7 result result NN cord-005902-5zuij5i3 47 8 of of IN cord-005902-5zuij5i3 47 9 toxin toxin NN cord-005902-5zuij5i3 47 10 - - HYPH cord-005902-5zuij5i3 47 11 induced induce VBN cord-005902-5zuij5i3 47 12 vascular vascular JJ cord-005902-5zuij5i3 47 13 occlusion occlusion NN cord-005902-5zuij5i3 47 14 . . . cord-005902-5zuij5i3 48 1 As as IN cord-005902-5zuij5i3 48 2 the the DT cord-005902-5zuij5i3 48 3 infection infection NN cord-005902-5zuij5i3 48 4 progresses progress VBZ cord-005902-5zuij5i3 48 5 more more JJR cord-005902-5zuij5i3 48 6 toxins toxin NNS cord-005902-5zuij5i3 48 7 are be VBP cord-005902-5zuij5i3 48 8 produced produce VBN cord-005902-5zuij5i3 48 9 and and CC cord-005902-5zuij5i3 48 10 tissue tissue NN cord-005902-5zuij5i3 48 11 destroyed destroy VBN cord-005902-5zuij5i3 48 12 . . . cord-005902-5zuij5i3 49 1 This this DT cord-005902-5zuij5i3 49 2 microvascular microvascular JJ cord-005902-5zuij5i3 49 3 occlusion occlusion NN cord-005902-5zuij5i3 49 4 contributes contribute VBZ cord-005902-5zuij5i3 49 5 to to TO cord-005902-5zuij5i3 49 6 shock shock NN cord-005902-5zuij5i3 49 7 and and CC cord-005902-5zuij5i3 49 8 organ organ NN cord-005902-5zuij5i3 49 9 dysfunction dysfunction NN cord-005902-5zuij5i3 49 10 . . . cord-005902-5zuij5i3 50 1 In in IN cord-005902-5zuij5i3 50 2 the the DT cord-005902-5zuij5i3 50 3 case case NN cord-005902-5zuij5i3 50 4 of of IN cord-005902-5zuij5i3 50 5 NF NF NNP cord-005902-5zuij5i3 50 6 early early JJ cord-005902-5zuij5i3 50 7 diagnosis diagnosis NN cord-005902-5zuij5i3 50 8 is be VBZ cord-005902-5zuij5i3 50 9 critical critical JJ cord-005902-5zuij5i3 50 10 with with IN cord-005902-5zuij5i3 50 11 respect respect NN cord-005902-5zuij5i3 50 12 to to IN cord-005902-5zuij5i3 50 13 the the DT cord-005902-5zuij5i3 50 14 survival survival NN cord-005902-5zuij5i3 50 15 of of IN cord-005902-5zuij5i3 50 16 the the DT cord-005902-5zuij5i3 50 17 patient patient NN cord-005902-5zuij5i3 50 18 . . . cord-005902-5zuij5i3 51 1 This this DT cord-005902-5zuij5i3 51 2 is be VBZ cord-005902-5zuij5i3 51 3 primarily primarily RB cord-005902-5zuij5i3 51 4 a a DT cord-005902-5zuij5i3 51 5 clinical clinical JJ cord-005902-5zuij5i3 51 6 diagnosis diagnosis NN cord-005902-5zuij5i3 51 7 with with IN cord-005902-5zuij5i3 51 8 no no DT cord-005902-5zuij5i3 51 9 typical typical JJ cord-005902-5zuij5i3 51 10 changes change NNS cord-005902-5zuij5i3 51 11 in in IN cord-005902-5zuij5i3 51 12 lab lab NN cord-005902-5zuij5i3 51 13 diagnostics diagnostic NNS cord-005902-5zuij5i3 51 14 . . . cord-005902-5zuij5i3 52 1 Serum serum NN cord-005902-5zuij5i3 52 2 creatinine creatinine NN cord-005902-5zuij5i3 52 3 phosphokinase phosphokinase NN cord-005902-5zuij5i3 52 4 ( ( -LRB- cord-005902-5zuij5i3 52 5 CPK CPK NNP cord-005902-5zuij5i3 52 6 ) ) -RRB- cord-005902-5zuij5i3 52 7 might may MD cord-005902-5zuij5i3 52 8 be be VB cord-005902-5zuij5i3 52 9 useful useful JJ cord-005902-5zuij5i3 52 10 in in IN cord-005902-5zuij5i3 52 11 detecting detect VBG cord-005902-5zuij5i3 52 12 deeper deep JJR cord-005902-5zuij5i3 52 13 soft soft JJ cord-005902-5zuij5i3 52 14 - - HYPH cord-005902-5zuij5i3 52 15 tissue tissue NN cord-005902-5zuij5i3 52 16 infections infection NNS cord-005902-5zuij5i3 52 17 . . . cord-005902-5zuij5i3 53 1 Even even RB cord-005902-5zuij5i3 53 2 a a DT cord-005902-5zuij5i3 53 3 mild mild JJ cord-005902-5zuij5i3 53 4 leukocytosis leukocytosis NN cord-005902-5zuij5i3 53 5 could could MD cord-005902-5zuij5i3 53 6 be be VB cord-005902-5zuij5i3 53 7 combined combine VBN cord-005902-5zuij5i3 53 8 with with IN cord-005902-5zuij5i3 53 9 an an DT cord-005902-5zuij5i3 53 10 increasing increase VBG cord-005902-5zuij5i3 53 11 percentage percentage NN cord-005902-5zuij5i3 53 12 of of IN cord-005902-5zuij5i3 53 13 immature immature JJ cord-005902-5zuij5i3 53 14 neutrophils neutrophil NNS cord-005902-5zuij5i3 53 15 and and CC cord-005902-5zuij5i3 53 16 should should MD cord-005902-5zuij5i3 53 17 be be VB cord-005902-5zuij5i3 53 18 a a DT cord-005902-5zuij5i3 53 19 reason reason NN cord-005902-5zuij5i3 53 20 to to TO cord-005902-5zuij5i3 53 21 be be VB cord-005902-5zuij5i3 53 22 suspicious suspicious JJ cord-005902-5zuij5i3 53 23 . . . cord-005902-5zuij5i3 54 1 Renal renal JJ cord-005902-5zuij5i3 54 2 impairment impairment NN cord-005902-5zuij5i3 54 3 precedes precede VBZ cord-005902-5zuij5i3 54 4 hypotension hypotension NN cord-005902-5zuij5i3 54 5 , , , cord-005902-5zuij5i3 54 6 as as RB cord-005902-5zuij5i3 54 7 well well RB cord-005902-5zuij5i3 54 8 as as IN cord-005902-5zuij5i3 54 9 hypoalbuminemia hypoalbuminemia NN cord-005902-5zuij5i3 54 10 and and CC cord-005902-5zuij5i3 54 11 hypocalcemia hypocalcemia NN cord-005902-5zuij5i3 54 12 are be VBP cord-005902-5zuij5i3 54 13 early early JJ cord-005902-5zuij5i3 54 14 signs sign NNS cord-005902-5zuij5i3 54 15 . . . cord-005902-5zuij5i3 55 1 Especially especially RB cord-005902-5zuij5i3 55 2 in in IN cord-005902-5zuij5i3 55 3 the the DT cord-005902-5zuij5i3 55 4 extremities extremity NNS cord-005902-5zuij5i3 55 5 the the DT cord-005902-5zuij5i3 55 6 bacteria bacteria NNS cord-005902-5zuij5i3 55 7 are be VBP cord-005902-5zuij5i3 55 8 inoculated inoculate VBN cord-005902-5zuij5i3 55 9 mostly mostly RB cord-005902-5zuij5i3 55 10 through through IN cord-005902-5zuij5i3 55 11 a a DT cord-005902-5zuij5i3 55 12 minor minor JJ cord-005902-5zuij5i3 55 13 skin skin NN cord-005902-5zuij5i3 55 14 lesion lesion NN cord-005902-5zuij5i3 55 15 . . . cord-005902-5zuij5i3 56 1 The the DT cord-005902-5zuij5i3 56 2 infection infection NN cord-005902-5zuij5i3 56 3 is be VBZ cord-005902-5zuij5i3 56 4 in in IN cord-005902-5zuij5i3 56 5 the the DT cord-005902-5zuij5i3 56 6 early early JJ cord-005902-5zuij5i3 56 7 stage stage NN cord-005902-5zuij5i3 56 8 characterized characterize VBN cord-005902-5zuij5i3 56 9 by by IN cord-005902-5zuij5i3 56 10 un un JJ cord-005902-5zuij5i3 56 11 - - JJ cord-005902-5zuij5i3 56 12 proportional proportional JJ cord-005902-5zuij5i3 56 13 local local JJ cord-005902-5zuij5i3 56 14 pain pain NN cord-005902-5zuij5i3 56 15 due due IN cord-005902-5zuij5i3 56 16 to to IN cord-005902-5zuij5i3 56 17 fascia fascia NN cord-005902-5zuij5i3 56 18 necrosis necrosis NN cord-005902-5zuij5i3 56 19 . . . cord-005902-5zuij5i3 57 1 After after IN cord-005902-5zuij5i3 57 2 this this DT cord-005902-5zuij5i3 57 3 , , , cord-005902-5zuij5i3 57 4 skin skin NN cord-005902-5zuij5i3 57 5 changes change NNS cord-005902-5zuij5i3 57 6 are be VBP cord-005902-5zuij5i3 57 7 visible visible JJ cord-005902-5zuij5i3 57 8 with with IN cord-005902-5zuij5i3 57 9 edema edema NN cord-005902-5zuij5i3 57 10 and and CC cord-005902-5zuij5i3 57 11 erythema erythema NN cord-005902-5zuij5i3 57 12 ( ( -LRB- cord-005902-5zuij5i3 57 13 Figure figure NN cord-005902-5zuij5i3 57 14 1 1 CD cord-005902-5zuij5i3 57 15 ) ) -RRB- cord-005902-5zuij5i3 57 16 . . . cord-005902-5zuij5i3 58 1 The the DT cord-005902-5zuij5i3 58 2 typical typical JJ cord-005902-5zuij5i3 58 3 pattern pattern NN cord-005902-5zuij5i3 58 4 of of IN cord-005902-5zuij5i3 58 5 skin skin NN cord-005902-5zuij5i3 58 6 necrosis necrosis NN cord-005902-5zuij5i3 58 7 with with IN cord-005902-5zuij5i3 58 8 or or CC cord-005902-5zuij5i3 58 9 without without IN cord-005902-5zuij5i3 58 10 blisters blister NNS cord-005902-5zuij5i3 58 11 is be VBZ cord-005902-5zuij5i3 58 12 found find VBN cord-005902-5zuij5i3 58 13 later later RB cord-005902-5zuij5i3 58 14 ; ; : cord-005902-5zuij5i3 58 15 however however RB cord-005902-5zuij5i3 58 16 , , , cord-005902-5zuij5i3 58 17 the the DT cord-005902-5zuij5i3 58 18 necrosis necrosis NN cord-005902-5zuij5i3 58 19 generally generally RB cord-005902-5zuij5i3 58 20 spreads spread VBZ cord-005902-5zuij5i3 58 21 rapidly rapidly RB cord-005902-5zuij5i3 58 22 in in IN cord-005902-5zuij5i3 58 23 the the DT cord-005902-5zuij5i3 58 24 proximal proximal JJ cord-005902-5zuij5i3 58 25 direction direction NN cord-005902-5zuij5i3 58 26 . . . cord-005902-5zuij5i3 59 1 The the DT cord-005902-5zuij5i3 59 2 necrosis necrosis NN cord-005902-5zuij5i3 59 3 of of IN cord-005902-5zuij5i3 59 4 the the DT cord-005902-5zuij5i3 59 5 fascia fascia NN cord-005902-5zuij5i3 59 6 has have VBZ cord-005902-5zuij5i3 59 7 already already RB cord-005902-5zuij5i3 59 8 much much RB cord-005902-5zuij5i3 59 9 further further JJ cord-005902-5zuij5i3 59 10 spread spread NN cord-005902-5zuij5i3 59 11 , , , cord-005902-5zuij5i3 59 12 compared compare VBN cord-005902-5zuij5i3 59 13 to to IN cord-005902-5zuij5i3 59 14 the the DT cord-005902-5zuij5i3 59 15 changes change NNS cord-005902-5zuij5i3 59 16 of of IN cord-005902-5zuij5i3 59 17 the the DT cord-005902-5zuij5i3 59 18 skin skin NN cord-005902-5zuij5i3 59 19 ( ( -LRB- cord-005902-5zuij5i3 59 20 Figure figure NN cord-005902-5zuij5i3 59 21 2 2 CD cord-005902-5zuij5i3 59 22 ) ) -RRB- cord-005902-5zuij5i3 59 23 . . . cord-005902-5zuij5i3 60 1 Crepitating crepitate VBG cord-005902-5zuij5i3 60 2 skin skin NN cord-005902-5zuij5i3 60 3 can can MD cord-005902-5zuij5i3 60 4 be be VB cord-005902-5zuij5i3 60 5 recognized recognize VBN cord-005902-5zuij5i3 60 6 in in IN cord-005902-5zuij5i3 60 7 about about RB cord-005902-5zuij5i3 60 8 50 50 CD cord-005902-5zuij5i3 60 9 % % NN cord-005902-5zuij5i3 60 10 of of IN cord-005902-5zuij5i3 60 11 the the DT cord-005902-5zuij5i3 60 12 patients patient NNS cord-005902-5zuij5i3 60 13 and and CC cord-005902-5zuij5i3 60 14 is be VBZ cord-005902-5zuij5i3 60 15 suspicious suspicious JJ cord-005902-5zuij5i3 60 16 of of IN cord-005902-5zuij5i3 60 17 a a DT cord-005902-5zuij5i3 60 18 poly poly JJ cord-005902-5zuij5i3 60 19 - - HYPH cord-005902-5zuij5i3 60 20 bacterial bacterial JJ cord-005902-5zuij5i3 60 21 infection infection NN cord-005902-5zuij5i3 60 22 . . . cord-005902-5zuij5i3 61 1 The the DT cord-005902-5zuij5i3 61 2 typical typical JJ cord-005902-5zuij5i3 61 3 clinical clinical JJ cord-005902-5zuij5i3 61 4 signs sign NNS cord-005902-5zuij5i3 61 5 are be VBP cord-005902-5zuij5i3 61 6 listed list VBN cord-005902-5zuij5i3 61 7 in in IN cord-005902-5zuij5i3 61 8 Table Table NNP cord-005902-5zuij5i3 61 9 4 4 CD cord-005902-5zuij5i3 61 10 . . . cord-005902-5zuij5i3 62 1 Since since IN cord-005902-5zuij5i3 62 2 the the DT cord-005902-5zuij5i3 62 3 time time NN cord-005902-5zuij5i3 62 4 to to IN cord-005902-5zuij5i3 62 5 surgery surgery NN cord-005902-5zuij5i3 62 6 needs need NNS cord-005902-5zuij5i3 62 7 to to TO cord-005902-5zuij5i3 62 8 be be VB cord-005902-5zuij5i3 62 9 diminished diminish VBN cord-005902-5zuij5i3 62 10 no no DT cord-005902-5zuij5i3 62 11 demanding demand VBG cord-005902-5zuij5i3 62 12 diagnostics diagnostic NNS cord-005902-5zuij5i3 62 13 like like IN cord-005902-5zuij5i3 62 14 histology histology NN cord-005902-5zuij5i3 62 15 or or CC cord-005902-5zuij5i3 62 16 bacterial bacterial JJ cord-005902-5zuij5i3 62 17 isolation isolation NN cord-005902-5zuij5i3 62 18 is be VBZ cord-005902-5zuij5i3 62 19 possible possible JJ cord-005902-5zuij5i3 62 20 . . . cord-005902-5zuij5i3 63 1 To to TO cord-005902-5zuij5i3 63 2 support support VB cord-005902-5zuij5i3 63 3 the the DT cord-005902-5zuij5i3 63 4 diagnosis diagnosis NN cord-005902-5zuij5i3 63 5 of of IN cord-005902-5zuij5i3 63 6 NF NF NNP cord-005902-5zuij5i3 63 7 ultrasound ultrasound NN cord-005902-5zuij5i3 63 8 can can MD cord-005902-5zuij5i3 63 9 be be VB cord-005902-5zuij5i3 63 10 used use VBN cord-005902-5zuij5i3 63 11 demonstrating demonstrate VBG cord-005902-5zuij5i3 63 12 fluid fluid NN cord-005902-5zuij5i3 63 13 between between IN cord-005902-5zuij5i3 63 14 the the DT cord-005902-5zuij5i3 63 15 muscle muscle NN cord-005902-5zuij5i3 63 16 and and CC cord-005902-5zuij5i3 63 17 subcutaneous subcutaneous JJ cord-005902-5zuij5i3 63 18 tissue tissue NN cord-005902-5zuij5i3 63 19 because because IN cord-005902-5zuij5i3 63 20 of of IN cord-005902-5zuij5i3 63 21 fascia fascia NN cord-005902-5zuij5i3 63 22 necrosis necrosis NN cord-005902-5zuij5i3 63 23 . . . cord-005902-5zuij5i3 64 1 Sometimes sometimes RB cord-005902-5zuij5i3 64 2 X X NNS cord-005902-5zuij5i3 64 3 - - NNS cord-005902-5zuij5i3 64 4 rays ray NNS cord-005902-5zuij5i3 64 5 can can MD cord-005902-5zuij5i3 64 6 reveal reveal VB cord-005902-5zuij5i3 64 7 gas gas NN cord-005902-5zuij5i3 64 8 formation formation NN cord-005902-5zuij5i3 64 9 which which WDT cord-005902-5zuij5i3 64 10 could could MD cord-005902-5zuij5i3 64 11 be be VB cord-005902-5zuij5i3 64 12 easily easily RB cord-005902-5zuij5i3 64 13 palpated palpate VBN cord-005902-5zuij5i3 64 14 . . . cord-005902-5zuij5i3 65 1 CT CT NNP cord-005902-5zuij5i3 65 2 or or CC cord-005902-5zuij5i3 65 3 MRI MRI NNP cord-005902-5zuij5i3 65 4 could could MD cord-005902-5zuij5i3 65 5 be be VB cord-005902-5zuij5i3 65 6 of of IN cord-005902-5zuij5i3 65 7 some some DT cord-005902-5zuij5i3 65 8 use use NN cord-005902-5zuij5i3 65 9 , , , cord-005902-5zuij5i3 65 10 but but CC cord-005902-5zuij5i3 65 11 with with IN cord-005902-5zuij5i3 65 12 little little JJ cord-005902-5zuij5i3 65 13 impact impact NN cord-005902-5zuij5i3 65 14 on on IN cord-005902-5zuij5i3 65 15 the the DT cord-005902-5zuij5i3 65 16 final final JJ cord-005902-5zuij5i3 65 17 decision decision NN cord-005902-5zuij5i3 65 18 to to TO cord-005902-5zuij5i3 65 19 proceed proceed VB cord-005902-5zuij5i3 65 20 to to IN cord-005902-5zuij5i3 65 21 the the DT cord-005902-5zuij5i3 65 22 operative operative JJ cord-005902-5zuij5i3 65 23 treatment treatment NN cord-005902-5zuij5i3 65 24 . . . cord-005902-5zuij5i3 66 1 MRI MRI NNP cord-005902-5zuij5i3 66 2 has have VBZ cord-005902-5zuij5i3 66 3 some some DT cord-005902-5zuij5i3 66 4 impact impact NN cord-005902-5zuij5i3 66 5 due due IN cord-005902-5zuij5i3 66 6 to to IN cord-005902-5zuij5i3 66 7 soft soft JJ cord-005902-5zuij5i3 66 8 tissue tissue NN cord-005902-5zuij5i3 66 9 and and CC cord-005902-5zuij5i3 66 10 multiplanar multiplanar NNP cord-005902-5zuij5i3 66 11 imaging imaging NN cord-005902-5zuij5i3 66 12 and and CC cord-005902-5zuij5i3 66 13 might may MD cord-005902-5zuij5i3 66 14 be be VB cord-005902-5zuij5i3 66 15 helpful helpful JJ cord-005902-5zuij5i3 66 16 in in IN cord-005902-5zuij5i3 66 17 case case NN cord-005902-5zuij5i3 66 18 the the DT cord-005902-5zuij5i3 66 19 source source NN cord-005902-5zuij5i3 66 20 of of IN cord-005902-5zuij5i3 66 21 infection infection NN cord-005902-5zuij5i3 66 22 lies lie VBZ cord-005902-5zuij5i3 66 23 deep deep RB cord-005902-5zuij5i3 66 24 inside inside IN cord-005902-5zuij5i3 66 25 the the DT cord-005902-5zuij5i3 66 26 body body NN cord-005902-5zuij5i3 66 27 . . . cord-005902-5zuij5i3 67 1 During during IN cord-005902-5zuij5i3 67 2 surgery surgery NN cord-005902-5zuij5i3 67 3 an an DT cord-005902-5zuij5i3 67 4 excision excision NN cord-005902-5zuij5i3 67 5 biopsy biopsy NN cord-005902-5zuij5i3 67 6 could could MD cord-005902-5zuij5i3 67 7 be be VB cord-005902-5zuij5i3 67 8 done do VBN cord-005902-5zuij5i3 67 9 , , , cord-005902-5zuij5i3 67 10 but but CC cord-005902-5zuij5i3 67 11 the the DT cord-005902-5zuij5i3 67 12 typical typical JJ cord-005902-5zuij5i3 67 13 discoloration discoloration NN cord-005902-5zuij5i3 67 14 of of IN cord-005902-5zuij5i3 67 15 the the DT cord-005902-5zuij5i3 67 16 fascia fascia NN cord-005902-5zuij5i3 67 17 ( ( -LRB- cord-005902-5zuij5i3 67 18 yellow yellow JJ cord-005902-5zuij5i3 67 19 to to IN cord-005902-5zuij5i3 67 20 green green JJ cord-005902-5zuij5i3 67 21 ) ) -RRB- cord-005902-5zuij5i3 67 22 and and CC cord-005902-5zuij5i3 67 23 the the DT cord-005902-5zuij5i3 67 24 possibility possibility NN cord-005902-5zuij5i3 67 25 to to TO cord-005902-5zuij5i3 67 26 manually manually RB cord-005902-5zuij5i3 67 27 dissect dissect VB cord-005902-5zuij5i3 67 28 the the DT cord-005902-5zuij5i3 67 29 fascia fascia NN cord-005902-5zuij5i3 67 30 ( ( -LRB- cord-005902-5zuij5i3 67 31 like like IN cord-005902-5zuij5i3 67 32 chewing chew VBG cord-005902-5zuij5i3 67 33 gum gum NN cord-005902-5zuij5i3 67 34 ) ) -RRB- cord-005902-5zuij5i3 67 35 will will MD cord-005902-5zuij5i3 67 36 assure assure VB cord-005902-5zuij5i3 67 37 the the DT cord-005902-5zuij5i3 67 38 diagnosis diagnosis NN cord-005902-5zuij5i3 67 39 . . . cord-005902-5zuij5i3 68 1 In in IN cord-005902-5zuij5i3 68 2 contrast contrast NN cord-005902-5zuij5i3 68 3 to to IN cord-005902-5zuij5i3 68 4 myositis myositis NN cord-005902-5zuij5i3 68 5 caused cause VBN cord-005902-5zuij5i3 68 6 by by IN cord-005902-5zuij5i3 68 7 streptococci streptococcus NNS cord-005902-5zuij5i3 68 8 the the DT cord-005902-5zuij5i3 68 9 muscles muscle NNS cord-005902-5zuij5i3 68 10 appear appear VBP cord-005902-5zuij5i3 68 11 normal normal JJ cord-005902-5zuij5i3 68 12 and and CC cord-005902-5zuij5i3 68 13 not not RB cord-005902-5zuij5i3 68 14 as as RB cord-005902-5zuij5i3 68 15 necrotic necrotic JJ cord-005902-5zuij5i3 68 16 with with IN cord-005902-5zuij5i3 68 17 a a DT cord-005902-5zuij5i3 68 18 discoloration discoloration NN cord-005902-5zuij5i3 68 19 , , , cord-005902-5zuij5i3 68 20 brown brown JJ cord-005902-5zuij5i3 68 21 to to IN cord-005902-5zuij5i3 68 22 grey grey VB cord-005902-5zuij5i3 68 23 , , , cord-005902-5zuij5i3 68 24 comparable comparable JJ cord-005902-5zuij5i3 68 25 to to IN cord-005902-5zuij5i3 68 26 loam loam NN cord-005902-5zuij5i3 68 27 . . . cord-005902-5zuij5i3 69 1 STSS STSS NNP cord-005902-5zuij5i3 69 2 is be VBZ cord-005902-5zuij5i3 69 3 more more RBR cord-005902-5zuij5i3 69 4 often often RB cord-005902-5zuij5i3 69 5 found find VBN cord-005902-5zuij5i3 69 6 in in IN cord-005902-5zuij5i3 69 7 association association NN cord-005902-5zuij5i3 69 8 with with IN cord-005902-5zuij5i3 69 9 pharyngitis pharyngitis NN cord-005902-5zuij5i3 69 10 , , , cord-005902-5zuij5i3 69 11 or or CC cord-005902-5zuij5i3 69 12 small small JJ cord-005902-5zuij5i3 69 13 lesions lesion NNS cord-005902-5zuij5i3 69 14 of of IN cord-005902-5zuij5i3 69 15 the the DT cord-005902-5zuij5i3 69 16 skin skin NN cord-005902-5zuij5i3 69 17 or or CC cord-005902-5zuij5i3 69 18 mucosa mucosa JJ cord-005902-5zuij5i3 69 19 ( ( -LRB- cord-005902-5zuij5i3 69 20 scratches scratch NNS cord-005902-5zuij5i3 69 21 , , , cord-005902-5zuij5i3 69 22 insect insect NN cord-005902-5zuij5i3 69 23 bites bite NNS cord-005902-5zuij5i3 69 24 ) ) -RRB- cord-005902-5zuij5i3 69 25 . . . cord-005902-5zuij5i3 70 1 This this DT cord-005902-5zuij5i3 70 2 syndrome syndrome NN cord-005902-5zuij5i3 70 3 appears appear VBZ cord-005902-5zuij5i3 70 4 in in IN cord-005902-5zuij5i3 70 5 normally normally RB cord-005902-5zuij5i3 70 6 healthy healthy JJ cord-005902-5zuij5i3 70 7 people people NNS cord-005902-5zuij5i3 70 8 of of IN cord-005902-5zuij5i3 70 9 all all DT cord-005902-5zuij5i3 70 10 ages age NNS cord-005902-5zuij5i3 70 11 , , , cord-005902-5zuij5i3 70 12 in in IN cord-005902-5zuij5i3 70 13 children child NNS cord-005902-5zuij5i3 70 14 more more RBR cord-005902-5zuij5i3 70 15 often often RB cord-005902-5zuij5i3 70 16 seen see VBN cord-005902-5zuij5i3 70 17 following follow VBG cord-005902-5zuij5i3 70 18 chickenpox chickenpox NN cord-005902-5zuij5i3 70 19 infection infection NN cord-005902-5zuij5i3 70 20 [ [ -LRB- cord-005902-5zuij5i3 70 21 16 16 CD cord-005902-5zuij5i3 70 22 ] ] -RRB- cord-005902-5zuij5i3 70 23 . . . cord-005902-5zuij5i3 71 1 Isolation isolation NN cord-005902-5zuij5i3 71 2 of of IN cord-005902-5zuij5i3 71 3 streptococci streptococcus NNS cord-005902-5zuij5i3 71 4 group group NN cord-005902-5zuij5i3 71 5 A A NNP cord-005902-5zuij5i3 71 6 is be VBZ cord-005902-5zuij5i3 71 7 typical typical JJ cord-005902-5zuij5i3 71 8 -also -also NN cord-005902-5zuij5i3 71 9 in in IN cord-005902-5zuij5i3 71 10 normally normally RB cord-005902-5zuij5i3 71 11 sterile sterile JJ cord-005902-5zuij5i3 71 12 body body NN cord-005902-5zuij5i3 71 13 compartments compartment NNS cord-005902-5zuij5i3 71 14 -and -and : cord-005902-5zuij5i3 71 15 of of IN cord-005902-5zuij5i3 71 16 course course NN cord-005902-5zuij5i3 71 17 the the DT cord-005902-5zuij5i3 71 18 signs sign NNS cord-005902-5zuij5i3 71 19 of of IN cord-005902-5zuij5i3 71 20 a a DT cord-005902-5zuij5i3 71 21 systemic systemic JJ cord-005902-5zuij5i3 71 22 shock shock NN cord-005902-5zuij5i3 71 23 . . . cord-005902-5zuij5i3 72 1 However however RB cord-005902-5zuij5i3 72 2 , , , cord-005902-5zuij5i3 72 3 50 50 CD cord-005902-5zuij5i3 72 4 % % NN cord-005902-5zuij5i3 72 5 of of IN cord-005902-5zuij5i3 72 6 the the DT cord-005902-5zuij5i3 72 7 STSS STSS NNP cord-005902-5zuij5i3 72 8 cases case NNS cord-005902-5zuij5i3 72 9 are be VBP cord-005902-5zuij5i3 72 10 accompanied accompany VBN cord-005902-5zuij5i3 72 11 by by IN cord-005902-5zuij5i3 72 12 NF NF NNP cord-005902-5zuij5i3 72 13 . . . cord-005902-5zuij5i3 73 1 The the DT cord-005902-5zuij5i3 73 2 typical typical JJ cord-005902-5zuij5i3 73 3 serious serious JJ cord-005902-5zuij5i3 73 4 soft soft JJ cord-005902-5zuij5i3 73 5 tissue tissue NN cord-005902-5zuij5i3 73 6 infections infection NNS cord-005902-5zuij5i3 73 7 are be VBP cord-005902-5zuij5i3 73 8 listed list VBN cord-005902-5zuij5i3 73 9 in in IN cord-005902-5zuij5i3 73 10 Table Table NNP cord-005902-5zuij5i3 73 11 5 5 CD cord-005902-5zuij5i3 73 12 . . . cord-005902-5zuij5i3 74 1 The the DT cord-005902-5zuij5i3 74 2 relevance relevance NN cord-005902-5zuij5i3 74 3 of of IN cord-005902-5zuij5i3 74 4 a a DT cord-005902-5zuij5i3 74 5 surgical surgical JJ cord-005902-5zuij5i3 74 6 management management NN cord-005902-5zuij5i3 74 7 could could MD cord-005902-5zuij5i3 74 8 be be VB cord-005902-5zuij5i3 74 9 proved prove VBN cord-005902-5zuij5i3 74 10 by by IN cord-005902-5zuij5i3 74 11 Kaiser Kaiser NNP cord-005902-5zuij5i3 74 12 and and CC cord-005902-5zuij5i3 74 13 Cerra Cerra NNP cord-005902-5zuij5i3 74 14 . . . cord-005902-5zuij5i3 75 1 A a DT cord-005902-5zuij5i3 75 2 reduced reduce VBN cord-005902-5zuij5i3 75 3 surgical surgical JJ cord-005902-5zuij5i3 75 4 treatment treatment NN cord-005902-5zuij5i3 75 5 was be VBD cord-005902-5zuij5i3 75 6 followed follow VBN cord-005902-5zuij5i3 75 7 by by IN cord-005902-5zuij5i3 75 8 a a DT cord-005902-5zuij5i3 75 9 significant significant JJ cord-005902-5zuij5i3 75 10 increase increase NN cord-005902-5zuij5i3 75 11 of of IN cord-005902-5zuij5i3 75 12 death death NN cord-005902-5zuij5i3 75 13 rate rate NN cord-005902-5zuij5i3 75 14 [ [ -LRB- cord-005902-5zuij5i3 75 15 20 20 CD cord-005902-5zuij5i3 75 16 ] ] -RRB- cord-005902-5zuij5i3 75 17 . . . cord-005902-5zuij5i3 76 1 There there EX cord-005902-5zuij5i3 76 2 is be VBZ cord-005902-5zuij5i3 76 3 no no DT cord-005902-5zuij5i3 76 4 space space NN cord-005902-5zuij5i3 76 5 for for IN cord-005902-5zuij5i3 76 6 incision incision NN cord-005902-5zuij5i3 76 7 and and CC cord-005902-5zuij5i3 76 8 drainage drainage NN cord-005902-5zuij5i3 76 9 or or CC cord-005902-5zuij5i3 76 10 limited limited JJ cord-005902-5zuij5i3 76 11 evacuation evacuation NN cord-005902-5zuij5i3 76 12 of of IN cord-005902-5zuij5i3 76 13 the the DT cord-005902-5zuij5i3 76 14 abscess abscess NN cord-005902-5zuij5i3 76 15 . . . cord-005902-5zuij5i3 77 1 The the DT cord-005902-5zuij5i3 77 2 only only JJ cord-005902-5zuij5i3 77 3 surgical surgical JJ cord-005902-5zuij5i3 77 4 option option NN cord-005902-5zuij5i3 77 5 is be VBZ cord-005902-5zuij5i3 77 6 the the DT cord-005902-5zuij5i3 77 7 radical radical JJ cord-005902-5zuij5i3 77 8 surgical surgical JJ cord-005902-5zuij5i3 77 9 excision excision NN cord-005902-5zuij5i3 77 10 of of IN cord-005902-5zuij5i3 77 11 the the DT cord-005902-5zuij5i3 77 12 infected infect VBN cord-005902-5zuij5i3 77 13 subcutaneous subcutaneous JJ cord-005902-5zuij5i3 77 14 tissue tissue NN cord-005902-5zuij5i3 77 15 in in IN cord-005902-5zuij5i3 77 16 particular particular JJ cord-005902-5zuij5i3 77 17 including include VBG cord-005902-5zuij5i3 77 18 the the DT cord-005902-5zuij5i3 77 19 grey grey JJ cord-005902-5zuij5i3 77 20 pale pale JJ cord-005902-5zuij5i3 77 21 fascia fascia NNS cord-005902-5zuij5i3 77 22 . . . cord-005902-5zuij5i3 78 1 In in IN cord-005902-5zuij5i3 78 2 these these DT cord-005902-5zuij5i3 78 3 cases case NNS cord-005902-5zuij5i3 78 4 , , , cord-005902-5zuij5i3 78 5 the the DT cord-005902-5zuij5i3 78 6 fascia fascia NN cord-005902-5zuij5i3 78 7 is be VBZ cord-005902-5zuij5i3 78 8 grey grey JJ cord-005902-5zuij5i3 78 9 , , , cord-005902-5zuij5i3 78 10 has have VBZ cord-005902-5zuij5i3 78 11 lost lose VBN cord-005902-5zuij5i3 78 12 all all PDT cord-005902-5zuij5i3 78 13 its -PRON- PRP$ cord-005902-5zuij5i3 78 14 strength strength NN cord-005902-5zuij5i3 78 15 and and CC cord-005902-5zuij5i3 78 16 can can MD cord-005902-5zuij5i3 78 17 more more RBR cord-005902-5zuij5i3 78 18 or or CC cord-005902-5zuij5i3 78 19 less less RBR cord-005902-5zuij5i3 78 20 be be VB cord-005902-5zuij5i3 78 21 pealed peal VBN cord-005902-5zuij5i3 78 22 off off RP cord-005902-5zuij5i3 78 23 . . . cord-005902-5zuij5i3 79 1 It -PRON- PRP cord-005902-5zuij5i3 79 2 is be VBZ cord-005902-5zuij5i3 79 3 essential essential JJ cord-005902-5zuij5i3 79 4 to to TO cord-005902-5zuij5i3 79 5 resect resect VB cord-005902-5zuij5i3 79 6 the the DT cord-005902-5zuij5i3 79 7 infected infected JJ cord-005902-5zuij5i3 79 8 fascia fascia NN cord-005902-5zuij5i3 79 9 and and CC cord-005902-5zuij5i3 79 10 to to TO cord-005902-5zuij5i3 79 11 debride debride VB cord-005902-5zuij5i3 79 12 into into IN cord-005902-5zuij5i3 79 13 healthy healthy JJ cord-005902-5zuij5i3 79 14 tissue tissue NN cord-005902-5zuij5i3 79 15 . . . cord-005902-5zuij5i3 80 1 Furthermore furthermore RB cord-005902-5zuij5i3 80 2 , , , cord-005902-5zuij5i3 80 3 it -PRON- PRP cord-005902-5zuij5i3 80 4 is be VBZ cord-005902-5zuij5i3 80 5 essential essential JJ cord-005902-5zuij5i3 80 6 to to TO cord-005902-5zuij5i3 80 7 follow follow VB cord-005902-5zuij5i3 80 8 up up RP cord-005902-5zuij5i3 80 9 by by IN cord-005902-5zuij5i3 80 10 surgical surgical JJ cord-005902-5zuij5i3 80 11 re re NNS cord-005902-5zuij5i3 80 12 - - NNS cord-005902-5zuij5i3 80 13 interventions intervention NNS cord-005902-5zuij5i3 80 14 after after IN cord-005902-5zuij5i3 80 15 a a DT cord-005902-5zuij5i3 80 16 short short JJ cord-005902-5zuij5i3 80 17 time time NN cord-005902-5zuij5i3 81 1 -even -even VBN cord-005902-5zuij5i3 82 1 again again RB cord-005902-5zuij5i3 82 2 on on IN cord-005902-5zuij5i3 82 3 the the DT cord-005902-5zuij5i3 82 4 same same JJ cord-005902-5zuij5i3 82 5 day day NN cord-005902-5zuij5i3 82 6 in in IN cord-005902-5zuij5i3 82 7 fulminant fulminant JJ cord-005902-5zuij5i3 82 8 cases case NNS cord-005902-5zuij5i3 82 9 or or CC cord-005902-5zuij5i3 82 10 at at IN cord-005902-5zuij5i3 82 11 least least JJS cord-005902-5zuij5i3 82 12 the the DT cord-005902-5zuij5i3 82 13 subsequent subsequent JJ cord-005902-5zuij5i3 82 14 day day NN cord-005902-5zuij5i3 82 15 . . . cord-005902-5zuij5i3 83 1 In in IN cord-005902-5zuij5i3 83 2 general general JJ cord-005902-5zuij5i3 83 3 this this DT cord-005902-5zuij5i3 83 4 regime regime NN cord-005902-5zuij5i3 83 5 is be VBZ cord-005902-5zuij5i3 83 6 followed follow VBN cord-005902-5zuij5i3 83 7 a a DT cord-005902-5zuij5i3 83 8 few few JJ cord-005902-5zuij5i3 83 9 days day NNS cord-005902-5zuij5i3 83 10 until until IN cord-005902-5zuij5i3 83 11 the the DT cord-005902-5zuij5i3 83 12 spreading spreading NN cord-005902-5zuij5i3 83 13 in in IN cord-005902-5zuij5i3 83 14 the the DT cord-005902-5zuij5i3 83 15 proximal proximal JJ cord-005902-5zuij5i3 83 16 direction direction NN cord-005902-5zuij5i3 83 17 has have VBZ cord-005902-5zuij5i3 83 18 been be VBN cord-005902-5zuij5i3 83 19 stopped stop VBN cord-005902-5zuij5i3 83 20 . . . cord-005902-5zuij5i3 84 1 An an DT cord-005902-5zuij5i3 84 2 amputation amputation NN cord-005902-5zuij5i3 84 3 in in IN cord-005902-5zuij5i3 84 4 the the DT cord-005902-5zuij5i3 84 5 extremities extremity NNS cord-005902-5zuij5i3 84 6 is be VBZ cord-005902-5zuij5i3 84 7 not not RB cord-005902-5zuij5i3 84 8 the the DT cord-005902-5zuij5i3 84 9 primary primary JJ cord-005902-5zuij5i3 84 10 treatment treatment NN cord-005902-5zuij5i3 84 11 , , , cord-005902-5zuij5i3 84 12 but but CC cord-005902-5zuij5i3 84 13 in in IN cord-005902-5zuij5i3 84 14 cases case NNS cord-005902-5zuij5i3 84 15 where where WRB cord-005902-5zuij5i3 84 16 the the DT cord-005902-5zuij5i3 84 17 whole whole JJ cord-005902-5zuij5i3 84 18 tissue tissue NN cord-005902-5zuij5i3 84 19 is be VBZ cord-005902-5zuij5i3 84 20 necrotic necrotic JJ cord-005902-5zuij5i3 84 21 and and CC cord-005902-5zuij5i3 84 22 most most JJS cord-005902-5zuij5i3 84 23 muscles muscle NNS cord-005902-5zuij5i3 84 24 involved involve VBN cord-005902-5zuij5i3 84 25 , , , cord-005902-5zuij5i3 84 26 this this DT cord-005902-5zuij5i3 84 27 might may MD cord-005902-5zuij5i3 84 28 be be VB cord-005902-5zuij5i3 84 29 the the DT cord-005902-5zuij5i3 84 30 only only JJ cord-005902-5zuij5i3 84 31 option option NN cord-005902-5zuij5i3 84 32 to to TO cord-005902-5zuij5i3 84 33 stop stop VB cord-005902-5zuij5i3 84 34 further further RB cord-005902-5zuij5i3 84 35 spreading spread VBG cord-005902-5zuij5i3 84 36 and and CC cord-005902-5zuij5i3 84 37 systemic systemic JJ cord-005902-5zuij5i3 84 38 sepsis sepsis NN cord-005902-5zuij5i3 84 39 with with IN cord-005902-5zuij5i3 84 40 multiple multiple JJ cord-005902-5zuij5i3 84 41 organ organ NN cord-005902-5zuij5i3 84 42 failure failure NN cord-005902-5zuij5i3 84 43 . . . cord-005902-5zuij5i3 85 1 These these DT cord-005902-5zuij5i3 85 2 amputations amputation NNS cord-005902-5zuij5i3 85 3 have have VBP cord-005902-5zuij5i3 85 4 to to TO cord-005902-5zuij5i3 85 5 be be VB cord-005902-5zuij5i3 85 6 performed perform VBN cord-005902-5zuij5i3 85 7 as as IN cord-005902-5zuij5i3 85 8 open open JJ cord-005902-5zuij5i3 85 9 amputations amputation NNS cord-005902-5zuij5i3 85 10 , , , cord-005902-5zuij5i3 85 11 again again RB cord-005902-5zuij5i3 85 12 requiring require VBG cord-005902-5zuij5i3 85 13 second second JJ cord-005902-5zuij5i3 85 14 look look NN cord-005902-5zuij5i3 85 15 operation operation NN cord-005902-5zuij5i3 85 16 and and CC cord-005902-5zuij5i3 85 17 secondary secondary JJ cord-005902-5zuij5i3 85 18 closure closure NN cord-005902-5zuij5i3 85 19 . . . cord-005902-5zuij5i3 86 1 After after IN cord-005902-5zuij5i3 86 2 primary primary JJ cord-005902-5zuij5i3 86 3 intensive intensive JJ cord-005902-5zuij5i3 86 4 care care NN cord-005902-5zuij5i3 86 5 and and CC cord-005902-5zuij5i3 86 6 control control NN cord-005902-5zuij5i3 86 7 of of IN cord-005902-5zuij5i3 86 8 the the DT cord-005902-5zuij5i3 86 9 infection infection NN cord-005902-5zuij5i3 86 10 and and CC cord-005902-5zuij5i3 86 11 sepsis sepsis NN cord-005902-5zuij5i3 86 12 ( ( -LRB- cord-005902-5zuij5i3 86 13 mostly mostly RB cord-005902-5zuij5i3 86 14 after after IN cord-005902-5zuij5i3 86 15 1 1 CD cord-005902-5zuij5i3 86 16 week week NN cord-005902-5zuij5i3 86 17 ) ) -RRB- cord-005902-5zuij5i3 86 18 reconstructive reconstructive JJ cord-005902-5zuij5i3 86 19 procedures procedure NNS cord-005902-5zuij5i3 86 20 are be VBP cord-005902-5zuij5i3 86 21 initialized initialize VBN cord-005902-5zuij5i3 86 22 reaching reach VBG cord-005902-5zuij5i3 86 23 from from IN cord-005902-5zuij5i3 86 24 secondary secondary JJ cord-005902-5zuij5i3 86 25 wound wound NN cord-005902-5zuij5i3 86 26 closure closure NN cord-005902-5zuij5i3 86 27 and and CC cord-005902-5zuij5i3 86 28 skin skin NN cord-005902-5zuij5i3 86 29 grafting grafting NN cord-005902-5zuij5i3 86 30 to to IN cord-005902-5zuij5i3 86 31 flap flap NN cord-005902-5zuij5i3 86 32 coverage coverage NN cord-005902-5zuij5i3 86 33 saving save VBG cord-005902-5zuij5i3 86 34 viable viable JJ cord-005902-5zuij5i3 86 35 tissue tissue NN cord-005902-5zuij5i3 86 36 and and CC cord-005902-5zuij5i3 86 37 restore restore VB cord-005902-5zuij5i3 86 38 function function NN cord-005902-5zuij5i3 86 39 . . . cord-005902-5zuij5i3 87 1 Histology Histology NNP cord-005902-5zuij5i3 87 2 Histology Histology NNP cord-005902-5zuij5i3 87 3 of of IN cord-005902-5zuij5i3 87 4 the the DT cord-005902-5zuij5i3 87 5 excised excise VBN cord-005902-5zuij5i3 87 6 tissue tissue NN cord-005902-5zuij5i3 87 7 reveals reveal VBZ cord-005902-5zuij5i3 87 8 infiltration infiltration NN cord-005902-5zuij5i3 87 9 of of IN cord-005902-5zuij5i3 87 10 fascia fascia NN cord-005902-5zuij5i3 87 11 by by IN cord-005902-5zuij5i3 87 12 polymorphic polymorphic JJ cord-005902-5zuij5i3 87 13 nuclear nuclear JJ cord-005902-5zuij5i3 87 14 cells cell NNS cord-005902-5zuij5i3 87 15 , , , cord-005902-5zuij5i3 87 16 with with IN cord-005902-5zuij5i3 87 17 peri peri JJ cord-005902-5zuij5i3 87 18 - - HYPH cord-005902-5zuij5i3 87 19 vascular vascular JJ cord-005902-5zuij5i3 87 20 focus focus NN cord-005902-5zuij5i3 87 21 . . . cord-005902-5zuij5i3 88 1 Sometimes sometimes RB cord-005902-5zuij5i3 88 2 bacteria bacteria NNS cord-005902-5zuij5i3 88 3 are be VBP cord-005902-5zuij5i3 88 4 detectable detectable JJ cord-005902-5zuij5i3 88 5 . . . cord-005902-5zuij5i3 89 1 Later later RB cord-005902-5zuij5i3 89 2 , , , cord-005902-5zuij5i3 89 3 a a DT cord-005902-5zuij5i3 89 4 co co JJ cord-005902-5zuij5i3 89 5 - - JJ cord-005902-5zuij5i3 89 6 liquation liquation JJ cord-005902-5zuij5i3 89 7 necrosis necrosis NN cord-005902-5zuij5i3 89 8 of of IN cord-005902-5zuij5i3 89 9 the the DT cord-005902-5zuij5i3 89 10 fascia fascia NN cord-005902-5zuij5i3 89 11 is be VBZ cord-005902-5zuij5i3 89 12 visible visible JJ cord-005902-5zuij5i3 89 13 , , , cord-005902-5zuij5i3 89 14 involving involve VBG cord-005902-5zuij5i3 89 15 subcutaneous subcutaneous JJ cord-005902-5zuij5i3 89 16 tissue tissue NN cord-005902-5zuij5i3 89 17 and and CC cord-005902-5zuij5i3 89 18 skin skin NN cord-005902-5zuij5i3 89 19 . . . cord-005902-5zuij5i3 90 1 The the DT cord-005902-5zuij5i3 90 2 tissues tissue NNS cord-005902-5zuij5i3 90 3 can can MD cord-005902-5zuij5i3 90 4 not not RB cord-005902-5zuij5i3 90 5 be be VB cord-005902-5zuij5i3 90 6 differentiated differentiate VBN cord-005902-5zuij5i3 90 7 anymore anymore RB cord-005902-5zuij5i3 90 8 and and CC cord-005902-5zuij5i3 90 9 muscle muscle NN cord-005902-5zuij5i3 90 10 tissue tissue NN cord-005902-5zuij5i3 90 11 is be VBZ cord-005902-5zuij5i3 90 12 involved involve VBN cord-005902-5zuij5i3 90 13 as as RB cord-005902-5zuij5i3 90 14 well well RB cord-005902-5zuij5i3 90 15 . . . cord-005902-5zuij5i3 91 1 Demanding demand VBG cord-005902-5zuij5i3 91 2 a a DT cord-005902-5zuij5i3 91 3 radical radical JJ cord-005902-5zuij5i3 91 4 debridement debridement NN cord-005902-5zuij5i3 91 5 , , , cord-005902-5zuij5i3 91 6 therefore therefore RB cord-005902-5zuij5i3 91 7 the the DT cord-005902-5zuij5i3 91 8 resulting result VBG cord-005902-5zuij5i3 91 9 wound wound NN cord-005902-5zuij5i3 91 10 areas area NNS cord-005902-5zuij5i3 91 11 are be VBP cord-005902-5zuij5i3 91 12 extensive extensive JJ cord-005902-5zuij5i3 91 13 in in IN cord-005902-5zuij5i3 91 14 most most JJS cord-005902-5zuij5i3 91 15 cases case NNS cord-005902-5zuij5i3 91 16 and and CC cord-005902-5zuij5i3 91 17 therefore therefore RB cord-005902-5zuij5i3 91 18 the the DT cord-005902-5zuij5i3 91 19 increased increase VBN cord-005902-5zuij5i3 91 20 fluid fluid JJ cord-005902-5zuij5i3 91 21 turnover turnover NN cord-005902-5zuij5i3 91 22 already already RB cord-005902-5zuij5i3 91 23 justifies justify VBZ cord-005902-5zuij5i3 91 24 an an DT cord-005902-5zuij5i3 91 25 intense intense JJ cord-005902-5zuij5i3 91 26 care care NN cord-005902-5zuij5i3 91 27 treatment treatment NN cord-005902-5zuij5i3 91 28 . . . cord-005902-5zuij5i3 92 1 An an DT cord-005902-5zuij5i3 92 2 adjusted adjusted JJ cord-005902-5zuij5i3 92 3 antibiotic antibiotic JJ cord-005902-5zuij5i3 92 4 regime regime NN cord-005902-5zuij5i3 92 5 is be VBZ cord-005902-5zuij5i3 92 6 mandatory mandatory JJ cord-005902-5zuij5i3 92 7 . . . cord-005902-5zuij5i3 93 1 In in IN cord-005902-5zuij5i3 93 2 undefined undefined JJ cord-005902-5zuij5i3 93 3 cases case NNS cord-005902-5zuij5i3 93 4 Gram gram NN cord-005902-5zuij5i3 93 5 - - HYPH cord-005902-5zuij5i3 93 6 negative negative JJ cord-005902-5zuij5i3 93 7 , , , cord-005902-5zuij5i3 93 8 Gram Gram NNP cord-005902-5zuij5i3 93 9 positive positive JJ cord-005902-5zuij5i3 93 10 and and CC cord-005902-5zuij5i3 93 11 anaerobic anaerobic JJ cord-005902-5zuij5i3 93 12 bacteria bacteria NNS cord-005902-5zuij5i3 93 13 must must MD cord-005902-5zuij5i3 93 14 be be VB cord-005902-5zuij5i3 93 15 addressed address VBN cord-005902-5zuij5i3 93 16 . . . cord-005902-5zuij5i3 94 1 Mono mono NN cord-005902-5zuij5i3 94 2 - - HYPH cord-005902-5zuij5i3 94 3 therapy therapy NN cord-005902-5zuij5i3 94 4 includes include VBZ cord-005902-5zuij5i3 94 5 imipenem imipenem NNP cord-005902-5zuij5i3 94 6 - - HYPH cord-005902-5zuij5i3 94 7 cilastatin cilastatin NNP cord-005902-5zuij5i3 94 8 , , , cord-005902-5zuij5i3 94 9 meropenem meropenem NNP cord-005902-5zuij5i3 94 10 , , , cord-005902-5zuij5i3 94 11 ertapenem ertapenem NNP cord-005902-5zuij5i3 94 12 , , , cord-005902-5zuij5i3 94 13 piperacillin piperacillin NNP cord-005902-5zuij5i3 94 14 / / SYM cord-005902-5zuij5i3 94 15 tazobactam tazobactam NNS cord-005902-5zuij5i3 94 16 and and CC cord-005902-5zuij5i3 94 17 tigecycline tigecycline NNP cord-005902-5zuij5i3 94 18 . . . cord-005902-5zuij5i3 95 1 A a DT cord-005902-5zuij5i3 95 2 combination combination NN cord-005902-5zuij5i3 95 3 - - HYPH cord-005902-5zuij5i3 95 4 therapy therapy NN cord-005902-5zuij5i3 95 5 adds add VBZ cord-005902-5zuij5i3 95 6 vancomycin vancomycin NN cord-005902-5zuij5i3 95 7 , , , cord-005902-5zuij5i3 95 8 linezolid linezolid NNP cord-005902-5zuij5i3 95 9 or or CC cord-005902-5zuij5i3 95 10 daptomycin daptomycin NNS cord-005902-5zuij5i3 95 11 to to IN cord-005902-5zuij5i3 95 12 a a DT cord-005902-5zuij5i3 95 13 carbapenem carbapenem NN cord-005902-5zuij5i3 95 14 or or CC cord-005902-5zuij5i3 95 15 b b NN cord-005902-5zuij5i3 95 16 - - : cord-005902-5zuij5i3 95 17 lactam/ lactam/ NN cord-005902-5zuij5i3 95 18 b b NN cord-005902-5zuij5i3 95 19 - - HYPH cord-005902-5zuij5i3 95 20 lactamase lactamase NN cord-005902-5zuij5i3 95 21 inhibitor inhibitor NN cord-005902-5zuij5i3 95 22 combination combination NN cord-005902-5zuij5i3 95 23 , , , cord-005902-5zuij5i3 95 24 if if IN cord-005902-5zuij5i3 95 25 methicilin methicilin JJ cord-005902-5zuij5i3 95 26 - - HYPH cord-005902-5zuij5i3 95 27 resistant resistant JJ cord-005902-5zuij5i3 95 28 staphylococci staphylococcus NNS cord-005902-5zuij5i3 95 29 are be VBP cord-005902-5zuij5i3 95 30 possible possible JJ cord-005902-5zuij5i3 95 31 . . . cord-005902-5zuij5i3 96 1 Another another DT cord-005902-5zuij5i3 96 2 combination combination NN cord-005902-5zuij5i3 96 3 therapy therapy NN cord-005902-5zuij5i3 96 4 includes include VBZ cord-005902-5zuij5i3 96 5 penicillin penicillin NN cord-005902-5zuij5i3 96 6 , , , cord-005902-5zuij5i3 96 7 clindamycin clindamycin NN cord-005902-5zuij5i3 96 8 and and CC cord-005902-5zuij5i3 96 9 fluoroquinolone fluoroquinolone NN cord-005902-5zuij5i3 96 10 or or CC cord-005902-5zuij5i3 96 11 aminogycoside aminogycoside NN cord-005902-5zuij5i3 96 12 to to TO cord-005902-5zuij5i3 96 13 cover cover VB cord-005902-5zuij5i3 96 14 Gram gram NN cord-005902-5zuij5i3 96 15 - - HYPH cord-005902-5zuij5i3 96 16 negative negative JJ cord-005902-5zuij5i3 96 17 bacteria bacteria NNS cord-005902-5zuij5i3 96 18 . . . cord-005902-5zuij5i3 97 1 In in IN cord-005902-5zuij5i3 97 2 a a DT cord-005902-5zuij5i3 97 3 case case NN cord-005902-5zuij5i3 97 4 of of IN cord-005902-5zuij5i3 97 5 streptococcal streptococcal JJ cord-005902-5zuij5i3 97 6 infection infection NN cord-005902-5zuij5i3 97 7 clindamycin clindamycin NN cord-005902-5zuij5i3 97 8 should should MD cord-005902-5zuij5i3 97 9 be be VB cord-005902-5zuij5i3 97 10 included include VBN cord-005902-5zuij5i3 97 11 into into IN cord-005902-5zuij5i3 97 12 the the DT cord-005902-5zuij5i3 97 13 medication medication NN cord-005902-5zuij5i3 97 14 , , , cord-005902-5zuij5i3 97 15 since since IN cord-005902-5zuij5i3 97 16 it -PRON- PRP cord-005902-5zuij5i3 97 17 has have VBZ cord-005902-5zuij5i3 97 18 been be VBN cord-005902-5zuij5i3 97 19 shown show VBN cord-005902-5zuij5i3 97 20 to to TO cord-005902-5zuij5i3 97 21 inhibit inhibit VB cord-005902-5zuij5i3 97 22 the the DT cord-005902-5zuij5i3 97 23 toxin toxin NN cord-005902-5zuij5i3 97 24 production production NN cord-005902-5zuij5i3 97 25 ( ( -LRB- cord-005902-5zuij5i3 97 26 m m NN cord-005902-5zuij5i3 97 27 - - HYPH cord-005902-5zuij5i3 97 28 protein protein NN cord-005902-5zuij5i3 97 29 and and CC cord-005902-5zuij5i3 97 30 exotoxin exotoxin NN cord-005902-5zuij5i3 97 31 ) ) -RRB- cord-005902-5zuij5i3 97 32 in in IN cord-005902-5zuij5i3 97 33 severe severe JJ cord-005902-5zuij5i3 97 34 cases case NNS cord-005902-5zuij5i3 97 35 [ [ -LRB- cord-005902-5zuij5i3 97 36 21 21 CD cord-005902-5zuij5i3 97 37 ] ] -RRB- cord-005902-5zuij5i3 97 38 . . . cord-005902-5zuij5i3 98 1 Especially especially RB cord-005902-5zuij5i3 98 2 streptolycin streptolycin NNS cord-005902-5zuij5i3 98 3 O o NN cord-005902-5zuij5i3 98 4 ( ( -LRB- cord-005902-5zuij5i3 98 5 SLO SLO NNP cord-005902-5zuij5i3 98 6 ) ) -RRB- cord-005902-5zuij5i3 98 7 induces induce VBZ cord-005902-5zuij5i3 98 8 changes change NNS cord-005902-5zuij5i3 98 9 to to IN cord-005902-5zuij5i3 98 10 the the DT cord-005902-5zuij5i3 98 11 leukocytes leukocyte NNS cord-005902-5zuij5i3 98 12 . . . cord-005902-5zuij5i3 99 1 It -PRON- PRP cord-005902-5zuij5i3 99 2 is be VBZ cord-005902-5zuij5i3 99 3 specific specific JJ cord-005902-5zuij5i3 99 4 to to IN cord-005902-5zuij5i3 99 5 phenoloxidase phenoloxidase NN cord-005902-5zuij5i3 99 6 important important JJ cord-005902-5zuij5i3 99 7 in in IN cord-005902-5zuij5i3 99 8 the the DT cord-005902-5zuij5i3 99 9 mechanism mechanism NN cord-005902-5zuij5i3 99 10 of of IN cord-005902-5zuij5i3 99 11 host host NN cord-005902-5zuij5i3 99 12 defense defense NN cord-005902-5zuij5i3 99 13 and and CC cord-005902-5zuij5i3 99 14 much much RB cord-005902-5zuij5i3 99 15 reduced reduce VBN cord-005902-5zuij5i3 99 16 in in IN cord-005902-5zuij5i3 99 17 NF nf NN cord-005902-5zuij5i3 99 18 - - HYPH cord-005902-5zuij5i3 99 19 cases case NNS cord-005902-5zuij5i3 99 20 due due JJ cord-005902-5zuij5i3 99 21 to to IN cord-005902-5zuij5i3 99 22 streptococci streptococcus NNS cord-005902-5zuij5i3 99 23 infection infection NN cord-005902-5zuij5i3 99 24 . . . cord-005902-5zuij5i3 100 1 This this DT cord-005902-5zuij5i3 100 2 significant significant JJ cord-005902-5zuij5i3 100 3 immunosuppressive immunosuppressive JJ cord-005902-5zuij5i3 100 4 effect effect NN cord-005902-5zuij5i3 100 5 is be VBZ cord-005902-5zuij5i3 100 6 accompanied accompany VBN cord-005902-5zuij5i3 100 7 by by IN cord-005902-5zuij5i3 100 8 the the DT cord-005902-5zuij5i3 100 9 effect effect NN cord-005902-5zuij5i3 100 10 that that WDT cord-005902-5zuij5i3 100 11 phenoloxidase phenoloxidase NN cord-005902-5zuij5i3 100 12 catalyses catalyse VBZ cord-005902-5zuij5i3 100 13 the the DT cord-005902-5zuij5i3 100 14 transformation transformation NN cord-005902-5zuij5i3 100 15 of of IN cord-005902-5zuij5i3 100 16 tyrosine tyrosine NN cord-005902-5zuij5i3 100 17 to to IN cord-005902-5zuij5i3 100 18 dehydroxy dehydroxy JJ cord-005902-5zuij5i3 100 19 - - HYPH cord-005902-5zuij5i3 100 20 phenylalanine phenylalanine NN cord-005902-5zuij5i3 100 21 necessary necessary JJ cord-005902-5zuij5i3 100 22 to to TO cord-005902-5zuij5i3 100 23 produce produce VB cord-005902-5zuij5i3 100 24 catecholamine catecholamine NN cord-005902-5zuij5i3 100 25 , , , cord-005902-5zuij5i3 100 26 one one CD cord-005902-5zuij5i3 100 27 reason reason NN cord-005902-5zuij5i3 100 28 a a DT cord-005902-5zuij5i3 100 29 patient patient NN cord-005902-5zuij5i3 100 30 with with IN cord-005902-5zuij5i3 100 31 NF NF NNP cord-005902-5zuij5i3 100 32 might may MD cord-005902-5zuij5i3 100 33 need need VB cord-005902-5zuij5i3 100 34 catecholamine catecholamine NN cord-005902-5zuij5i3 100 35 substitution substitution NN cord-005902-5zuij5i3 100 36 . . . cord-005902-5zuij5i3 101 1 Additionally additionally RB cord-005902-5zuij5i3 101 2 , , , cord-005902-5zuij5i3 101 3 some some DT cord-005902-5zuij5i3 101 4 immunotherapies immunotherapy NNS cord-005902-5zuij5i3 101 5 ( ( -LRB- cord-005902-5zuij5i3 101 6 e.g. e.g. RB cord-005902-5zuij5i3 101 7 , , , cord-005902-5zuij5i3 101 8 immunoglobulins immunoglobulin NNS cord-005902-5zuij5i3 101 9 ) ) -RRB- cord-005902-5zuij5i3 101 10 are be VBP cord-005902-5zuij5i3 101 11 also also RB cord-005902-5zuij5i3 101 12 suggested suggest VBN cord-005902-5zuij5i3 101 13 by by IN cord-005902-5zuij5i3 101 14 some some DT cord-005902-5zuij5i3 101 15 authors author NNS cord-005902-5zuij5i3 101 16 [ [ -LRB- cord-005902-5zuij5i3 101 17 13 13 CD cord-005902-5zuij5i3 101 18 ] ] -RRB- cord-005902-5zuij5i3 101 19 . . . cord-005902-5zuij5i3 102 1 The the DT cord-005902-5zuij5i3 102 2 mechanism mechanism NN cord-005902-5zuij5i3 102 3 is be VBZ cord-005902-5zuij5i3 102 4 believed believe VBN cord-005902-5zuij5i3 102 5 to to TO cord-005902-5zuij5i3 102 6 be be VB cord-005902-5zuij5i3 102 7 related relate VBN cord-005902-5zuij5i3 102 8 to to IN cord-005902-5zuij5i3 102 9 the the DT cord-005902-5zuij5i3 102 10 neutralization neutralization NN cord-005902-5zuij5i3 102 11 of of IN cord-005902-5zuij5i3 102 12 superantigen superantigen NN cord-005902-5zuij5i3 102 13 activity activity NN cord-005902-5zuij5i3 102 14 and and CC cord-005902-5zuij5i3 102 15 reduction reduction NN cord-005902-5zuij5i3 102 16 of of IN cord-005902-5zuij5i3 102 17 TNF TNF NNP cord-005902-5zuij5i3 102 18 - - : cord-005902-5zuij5i3 102 19 a a NNP cord-005902-5zuij5i3 102 20 and and CC cord-005902-5zuij5i3 102 21 IL-6 IL-6 NNP cord-005902-5zuij5i3 102 22 . . . cord-005902-5zuij5i3 103 1 Intensive intensive JJ cord-005902-5zuij5i3 103 2 Care care NN cord-005902-5zuij5i3 103 3 Therapy therapy NN cord-005902-5zuij5i3 104 1 Various various JJ cord-005902-5zuij5i3 104 2 efforts effort NNS cord-005902-5zuij5i3 104 3 have have VBP cord-005902-5zuij5i3 104 4 been be VBN cord-005902-5zuij5i3 104 5 made make VBN cord-005902-5zuij5i3 104 6 to to TO cord-005902-5zuij5i3 104 7 categorize categorize VB cord-005902-5zuij5i3 104 8 patients patient NNS cord-005902-5zuij5i3 104 9 with with IN cord-005902-5zuij5i3 104 10 respect respect NN cord-005902-5zuij5i3 104 11 to to IN cord-005902-5zuij5i3 104 12 the the DT cord-005902-5zuij5i3 104 13 risk risk NN cord-005902-5zuij5i3 104 14 of of IN cord-005902-5zuij5i3 104 15 mortality mortality NN cord-005902-5zuij5i3 104 16 . . . cord-005902-5zuij5i3 105 1 Negative negative JJ cord-005902-5zuij5i3 105 2 parameters parameter NNS cord-005902-5zuij5i3 105 3 are be VBP cord-005902-5zuij5i3 105 4 age age NN cord-005902-5zuij5i3 105 5 above above IN cord-005902-5zuij5i3 105 6 50 50 CD cord-005902-5zuij5i3 105 7 years year NNS cord-005902-5zuij5i3 105 8 , , , cord-005902-5zuij5i3 105 9 WBC WBC NNP cord-005902-5zuij5i3 105 10 > > XX cord-005902-5zuij5i3 106 1 40,000 40,000 CD cord-005902-5zuij5i3 106 2 cells/ cells/ SYM cord-005902-5zuij5i3 106 3 mm mm NNP cord-005902-5zuij5i3 106 4 3 3 CD cord-005902-5zuij5i3 106 5 , , , cord-005902-5zuij5i3 106 6 hematocrit hematocrit NN cord-005902-5zuij5i3 106 7 > > XX cord-005902-5zuij5i3 106 8 50 50 CD cord-005902-5zuij5i3 106 9 % % NN cord-005902-5zuij5i3 106 10 , , , cord-005902-5zuij5i3 106 11 HR hr NN cord-005902-5zuij5i3 106 12 > > XX cord-005902-5zuij5i3 107 1 100 100 CD cord-005902-5zuij5i3 107 2 , , , cord-005902-5zuij5i3 107 3 temperature temperature NN cord-005902-5zuij5i3 108 1 < < NNP cord-005902-5zuij5i3 108 2 37 37 CD cord-005902-5zuij5i3 108 3 ° ° NN cord-005902-5zuij5i3 108 4 C c NN cord-005902-5zuij5i3 108 5 and and CC cord-005902-5zuij5i3 108 6 creatinine creatinine NN cord-005902-5zuij5i3 109 1 > > XX cord-005902-5zuij5i3 110 1 15 15 CD cord-005902-5zuij5i3 110 2 mg mg NNP cord-005902-5zuij5i3 110 3 / / SYM cord-005902-5zuij5i3 110 4 dl dl NNP cord-005902-5zuij5i3 110 5 [ [ -LRB- cord-005902-5zuij5i3 110 6 22 22 CD cord-005902-5zuij5i3 110 7 ] ] -RRB- cord-005902-5zuij5i3 110 8 . . . cord-005902-5zuij5i3 111 1 If if IN cord-005902-5zuij5i3 111 2 the the DT cord-005902-5zuij5i3 111 3 patient patient NN cord-005902-5zuij5i3 111 4 develops develop VBZ cord-005902-5zuij5i3 111 5 a a DT cord-005902-5zuij5i3 111 6 septic septic JJ cord-005902-5zuij5i3 111 7 shock shock NN cord-005902-5zuij5i3 111 8 or or CC cord-005902-5zuij5i3 111 9 STSS STSS NNP cord-005902-5zuij5i3 111 10 an an DT cord-005902-5zuij5i3 111 11 acute acute JJ cord-005902-5zuij5i3 111 12 respiratory respiratory JJ cord-005902-5zuij5i3 111 13 distress distress NN cord-005902-5zuij5i3 111 14 syndrome syndrome NN cord-005902-5zuij5i3 111 15 ( ( -LRB- cord-005902-5zuij5i3 111 16 ARDS ARDS NNP cord-005902-5zuij5i3 111 17 ) ) -RRB- cord-005902-5zuij5i3 111 18 is be VBZ cord-005902-5zuij5i3 111 19 also also RB cord-005902-5zuij5i3 111 20 very very RB cord-005902-5zuij5i3 111 21 likely likely JJ cord-005902-5zuij5i3 111 22 ( ( -LRB- cord-005902-5zuij5i3 111 23 app app NN cord-005902-5zuij5i3 111 24 . . . cord-005902-5zuij5i3 112 1 50 50 CD cord-005902-5zuij5i3 112 2 % % NN cord-005902-5zuij5i3 112 3 ) ) -RRB- cord-005902-5zuij5i3 112 4 and and CC cord-005902-5zuij5i3 112 5 needs need VBZ cord-005902-5zuij5i3 112 6 mostly mostly RB cord-005902-5zuij5i3 112 7 intubation intubation NN cord-005902-5zuij5i3 112 8 and and CC cord-005902-5zuij5i3 112 9 mechanical mechanical JJ cord-005902-5zuij5i3 112 10 ventilation ventilation NN cord-005902-5zuij5i3 112 11 to to TO cord-005902-5zuij5i3 112 12 achieve achieve VB cord-005902-5zuij5i3 112 13 adequate adequate JJ cord-005902-5zuij5i3 112 14 oxygen oxygen NN cord-005902-5zuij5i3 112 15 supply supply NN cord-005902-5zuij5i3 112 16 . . . cord-005902-5zuij5i3 113 1 Every every DT cord-005902-5zuij5i3 113 2 patient patient NN cord-005902-5zuij5i3 113 3 with with IN cord-005902-5zuij5i3 113 4 signs sign NNS cord-005902-5zuij5i3 113 5 of of IN cord-005902-5zuij5i3 113 6 sepsis sepsis NN cord-005902-5zuij5i3 113 7 or or CC cord-005902-5zuij5i3 113 8 impaired impair VBN cord-005902-5zuij5i3 113 9 immune immune JJ cord-005902-5zuij5i3 113 10 response response NN cord-005902-5zuij5i3 113 11 should should MD cord-005902-5zuij5i3 113 12 have have VB cord-005902-5zuij5i3 113 13 intensive intensive JJ cord-005902-5zuij5i3 113 14 care care NN cord-005902-5zuij5i3 113 15 treatment treatment NN cord-005902-5zuij5i3 113 16 , , , cord-005902-5zuij5i3 113 17 since since IN cord-005902-5zuij5i3 113 18 organ organ NN cord-005902-5zuij5i3 113 19 failure failure NN cord-005902-5zuij5i3 113 20 is be VBZ cord-005902-5zuij5i3 113 21 very very RB cord-005902-5zuij5i3 113 22 common common JJ cord-005902-5zuij5i3 113 23 in in IN cord-005902-5zuij5i3 113 24 the the DT cord-005902-5zuij5i3 113 25 time time NN cord-005902-5zuij5i3 113 26 course course NN cord-005902-5zuij5i3 113 27 of of IN cord-005902-5zuij5i3 113 28 NF nf NN cord-005902-5zuij5i3 113 29 . . . cord-005902-5zuij5i3 114 1 The the DT cord-005902-5zuij5i3 114 2 patients patient NNS cord-005902-5zuij5i3 114 3 are be VBP cord-005902-5zuij5i3 114 4 at at IN cord-005902-5zuij5i3 114 5 an an DT cord-005902-5zuij5i3 114 6 extremely extremely RB cord-005902-5zuij5i3 114 7 high high JJ cord-005902-5zuij5i3 114 8 risk risk NN cord-005902-5zuij5i3 114 9 to to TO cord-005902-5zuij5i3 114 10 run run VB cord-005902-5zuij5i3 114 11 into into IN cord-005902-5zuij5i3 114 12 systemic systemic JJ cord-005902-5zuij5i3 114 13 sepsis sepsis NN cord-005902-5zuij5i3 114 14 with with IN cord-005902-5zuij5i3 114 15 a a DT cord-005902-5zuij5i3 114 16 poor poor JJ cord-005902-5zuij5i3 114 17 prognosis prognosis NN cord-005902-5zuij5i3 114 18 . . . cord-005902-5zuij5i3 115 1 Good good JJ cord-005902-5zuij5i3 115 2 oxygenation oxygenation NN cord-005902-5zuij5i3 115 3 , , , cord-005902-5zuij5i3 115 4 cardiac cardiac JJ cord-005902-5zuij5i3 115 5 output output NN cord-005902-5zuij5i3 115 6 and and CC cord-005902-5zuij5i3 115 7 control control NN cord-005902-5zuij5i3 115 8 of of IN cord-005902-5zuij5i3 115 9 homeostasis homeostasis NN cord-005902-5zuij5i3 115 10 are be VBP cord-005902-5zuij5i3 115 11 the the DT cord-005902-5zuij5i3 115 12 primary primary JJ cord-005902-5zuij5i3 115 13 goals goal NNS cord-005902-5zuij5i3 115 14 in in IN cord-005902-5zuij5i3 115 15 treating treat VBG cord-005902-5zuij5i3 115 16 a a DT cord-005902-5zuij5i3 115 17 systemic systemic JJ cord-005902-5zuij5i3 115 18 sepsis sepsis NN cord-005902-5zuij5i3 115 19 and and CC cord-005902-5zuij5i3 115 20 septic septic JJ cord-005902-5zuij5i3 115 21 shock shock NN cord-005902-5zuij5i3 115 22 according accord VBG cord-005902-5zuij5i3 115 23 to to IN cord-005902-5zuij5i3 115 24 the the DT cord-005902-5zuij5i3 115 25 current current JJ cord-005902-5zuij5i3 115 26 guidelines guideline NNS cord-005902-5zuij5i3 115 27 [ [ -LRB- cord-005902-5zuij5i3 115 28 23 23 CD cord-005902-5zuij5i3 115 29 ] ] -RRB- cord-005902-5zuij5i3 115 30 . . . cord-005902-5zuij5i3 116 1 These these DT cord-005902-5zuij5i3 116 2 guidelines guideline NNS cord-005902-5zuij5i3 116 3 have have VBP cord-005902-5zuij5i3 116 4 to to TO cord-005902-5zuij5i3 116 5 be be VB cord-005902-5zuij5i3 116 6 included include VBN cord-005902-5zuij5i3 116 7 stepwise stepwise RB cord-005902-5zuij5i3 116 8 in in IN cord-005902-5zuij5i3 116 9 the the DT cord-005902-5zuij5i3 116 10 treatment treatment NN cord-005902-5zuij5i3 116 11 of of IN cord-005902-5zuij5i3 116 12 sepsis sepsis NN cord-005902-5zuij5i3 116 13 due due IN cord-005902-5zuij5i3 116 14 to to IN cord-005902-5zuij5i3 116 15 necrotizing necrotize VBG cord-005902-5zuij5i3 116 16 fasciitis fasciitis NN cord-005902-5zuij5i3 116 17 . . . cord-005902-5zuij5i3 117 1 Additional additional JJ cord-005902-5zuij5i3 117 2 treatment treatment NN cord-005902-5zuij5i3 117 3 options option NNS cord-005902-5zuij5i3 117 4 to to TO cord-005902-5zuij5i3 117 5 enhance enhance VB cord-005902-5zuij5i3 117 6 systemic systemic JJ cord-005902-5zuij5i3 117 7 toxin toxin NN cord-005902-5zuij5i3 117 8 and and CC cord-005902-5zuij5i3 117 9 mediator mediator NN cord-005902-5zuij5i3 117 10 reduction reduction NN cord-005902-5zuij5i3 117 11 have have VBP cord-005902-5zuij5i3 117 12 been be VBN cord-005902-5zuij5i3 117 13 discussed discuss VBN cord-005902-5zuij5i3 117 14 , , , cord-005902-5zuij5i3 117 15 such such JJ cord-005902-5zuij5i3 117 16 as as IN cord-005902-5zuij5i3 117 17 continuous continuous JJ cord-005902-5zuij5i3 117 18 hemofiltration hemofiltration NN cord-005902-5zuij5i3 117 19 [ [ -LRB- cord-005902-5zuij5i3 117 20 24 24 CD cord-005902-5zuij5i3 117 21 ] ] -RRB- cord-005902-5zuij5i3 117 22 . . . cord-005902-5zuij5i3 118 1 Due due IN cord-005902-5zuij5i3 118 2 to to IN cord-005902-5zuij5i3 118 3 the the DT cord-005902-5zuij5i3 118 4 variation variation NN cord-005902-5zuij5i3 118 5 and and CC cord-005902-5zuij5i3 118 6 limited limited JJ cord-005902-5zuij5i3 118 7 number number NN cord-005902-5zuij5i3 118 8 of of IN cord-005902-5zuij5i3 118 9 patients patient NNS cord-005902-5zuij5i3 118 10 in in IN cord-005902-5zuij5i3 118 11 single single JJ cord-005902-5zuij5i3 118 12 centers center NNS cord-005902-5zuij5i3 118 13 , , , cord-005902-5zuij5i3 118 14 this this DT cord-005902-5zuij5i3 118 15 approach approach NN cord-005902-5zuij5i3 118 16 has have VBZ cord-005902-5zuij5i3 118 17 been be VBN cord-005902-5zuij5i3 118 18 only only RB cord-005902-5zuij5i3 118 19 applied apply VBN cord-005902-5zuij5i3 118 20 in in IN cord-005902-5zuij5i3 118 21 isolated isolated JJ cord-005902-5zuij5i3 118 22 cases case NNS cord-005902-5zuij5i3 118 23 [ [ -LRB- cord-005902-5zuij5i3 118 24 25 25 CD cord-005902-5zuij5i3 118 25 ] ] -RRB- cord-005902-5zuij5i3 118 26 . . . cord-005902-5zuij5i3 119 1 Besides besides IN cord-005902-5zuij5i3 119 2 the the DT cord-005902-5zuij5i3 119 3 basic basic JJ cord-005902-5zuij5i3 119 4 treatment treatment NN cord-005902-5zuij5i3 119 5 including include VBG cord-005902-5zuij5i3 119 6 intensive intensive JJ cord-005902-5zuij5i3 119 7 care care NN cord-005902-5zuij5i3 119 8 medicine medicine NN cord-005902-5zuij5i3 119 9 and and CC cord-005902-5zuij5i3 119 10 surgical surgical JJ cord-005902-5zuij5i3 119 11 debridement debridement NN cord-005902-5zuij5i3 119 12 numerous numerous JJ cord-005902-5zuij5i3 119 13 adjuvant adjuvant JJ cord-005902-5zuij5i3 119 14 therapies therapy NNS cord-005902-5zuij5i3 119 15 have have VBP cord-005902-5zuij5i3 119 16 been be VBN cord-005902-5zuij5i3 119 17 recommended recommend VBN cord-005902-5zuij5i3 119 18 with with IN cord-005902-5zuij5i3 119 19 respect respect NN cord-005902-5zuij5i3 119 20 to to IN cord-005902-5zuij5i3 119 21 the the DT cord-005902-5zuij5i3 119 22 systemic systemic JJ cord-005902-5zuij5i3 119 23 management management NN cord-005902-5zuij5i3 119 24 of of IN cord-005902-5zuij5i3 119 25 these these DT cord-005902-5zuij5i3 119 26 infections infection NNS cord-005902-5zuij5i3 119 27 as as RB cord-005902-5zuij5i3 119 28 well well RB cord-005902-5zuij5i3 119 29 as as IN cord-005902-5zuij5i3 119 30 possibilities possibility NNS cord-005902-5zuij5i3 119 31 for for IN cord-005902-5zuij5i3 119 32 local local JJ cord-005902-5zuij5i3 119 33 wound wound NN cord-005902-5zuij5i3 119 34 treatment treatment NN cord-005902-5zuij5i3 119 35 . . . cord-005902-5zuij5i3 120 1 Hyperbaric hyperbaric NN cord-005902-5zuij5i3 120 2 Oxygenation oxygenation NN cord-005902-5zuij5i3 120 3 ( ( -LRB- cord-005902-5zuij5i3 120 4 HBO HBO NNP cord-005902-5zuij5i3 120 5 ) ) -RRB- cord-005902-5zuij5i3 121 1 Necrotizing necrotize VBG cord-005902-5zuij5i3 121 2 Infections infection NNS cord-005902-5zuij5i3 121 3 are be VBP cord-005902-5zuij5i3 121 4 considered consider VBN cord-005902-5zuij5i3 121 5 to to TO cord-005902-5zuij5i3 121 6 be be VB cord-005902-5zuij5i3 121 7 one one CD cord-005902-5zuij5i3 121 8 of of IN cord-005902-5zuij5i3 121 9 the the DT cord-005902-5zuij5i3 121 10 primary primary JJ cord-005902-5zuij5i3 121 11 indications indication NNS cord-005902-5zuij5i3 121 12 for for IN cord-005902-5zuij5i3 121 13 HBO HBO NNP cord-005902-5zuij5i3 121 14 as as RB cord-005902-5zuij5i3 121 15 well well RB cord-005902-5zuij5i3 121 16 as as IN cord-005902-5zuij5i3 121 17 decompression decompression NN cord-005902-5zuij5i3 121 18 disease disease NN cord-005902-5zuij5i3 121 19 , , , cord-005902-5zuij5i3 121 20 gas gas NN cord-005902-5zuij5i3 121 21 embolism embolism NN cord-005902-5zuij5i3 121 22 , , , cord-005902-5zuij5i3 121 23 CO co NN cord-005902-5zuij5i3 121 24 - - : cord-005902-5zuij5i3 121 25 and and CC cord-005902-5zuij5i3 121 26 smoke smoke NN cord-005902-5zuij5i3 121 27 intoxication intoxication NN cord-005902-5zuij5i3 121 28 , , , cord-005902-5zuij5i3 121 29 anaerobic anaerobic JJ cord-005902-5zuij5i3 121 30 infections infection NNS cord-005902-5zuij5i3 121 31 ( ( -LRB- cord-005902-5zuij5i3 121 32 clostridia clostridia JJ cord-005902-5zuij5i3 121 33 infections infection NNS cord-005902-5zuij5i3 121 34 ) ) -RRB- cord-005902-5zuij5i3 121 35 and and CC cord-005902-5zuij5i3 121 36 radionecrosis radionecrosis NN cord-005902-5zuij5i3 121 37 [ [ -LRB- cord-005902-5zuij5i3 121 38 26 26 CD cord-005902-5zuij5i3 121 39 ] ] -RRB- cord-005902-5zuij5i3 121 40 . . . cord-005902-5zuij5i3 122 1 HBO HBO NNP cord-005902-5zuij5i3 122 2 - - HYPH cord-005902-5zuij5i3 122 3 therapy therapy NN cord-005902-5zuij5i3 122 4 is be VBZ cord-005902-5zuij5i3 122 5 able able JJ cord-005902-5zuij5i3 122 6 to to TO cord-005902-5zuij5i3 122 7 increase increase VB cord-005902-5zuij5i3 122 8 blood blood NN cord-005902-5zuij5i3 122 9 oxygen oxygen NN cord-005902-5zuij5i3 122 10 content content NN cord-005902-5zuij5i3 122 11 by by IN cord-005902-5zuij5i3 122 12 25 25 CD cord-005902-5zuij5i3 122 13 % % NN cord-005902-5zuij5i3 122 14 and and CC cord-005902-5zuij5i3 122 15 thereby thereby RB cord-005902-5zuij5i3 122 16 tissue tissue NN cord-005902-5zuij5i3 122 17 oxygenation oxygenation NN cord-005902-5zuij5i3 122 18 tenfold tenfold IN cord-005902-5zuij5i3 122 19 [ [ -LRB- cord-005902-5zuij5i3 122 20 27 27 CD cord-005902-5zuij5i3 122 21 ] ] -RRB- cord-005902-5zuij5i3 122 22 . . . cord-005902-5zuij5i3 123 1 Other other JJ cord-005902-5zuij5i3 123 2 effects effect NNS cord-005902-5zuij5i3 123 3 related relate VBN cord-005902-5zuij5i3 123 4 to to IN cord-005902-5zuij5i3 123 5 this this DT cord-005902-5zuij5i3 123 6 treatment treatment NN cord-005902-5zuij5i3 123 7 are be VBP cord-005902-5zuij5i3 123 8 vasoconstriction vasoconstriction NN cord-005902-5zuij5i3 123 9 , , , cord-005902-5zuij5i3 123 10 reduced reduced JJ cord-005902-5zuij5i3 123 11 leukocyte leukocyte NN cord-005902-5zuij5i3 123 12 sequestration sequestration NN cord-005902-5zuij5i3 123 13 , , , cord-005902-5zuij5i3 123 14 lipid lipid NN cord-005902-5zuij5i3 123 15 peroxidation peroxidation NN cord-005902-5zuij5i3 123 16 , , , cord-005902-5zuij5i3 123 17 free free JJ cord-005902-5zuij5i3 123 18 radical radical JJ cord-005902-5zuij5i3 123 19 scavenging scavenging NN cord-005902-5zuij5i3 123 20 and and CC cord-005902-5zuij5i3 123 21 reduction reduction NN cord-005902-5zuij5i3 123 22 of of IN cord-005902-5zuij5i3 123 23 tissue tissue NN cord-005902-5zuij5i3 123 24 edema edema NN cord-005902-5zuij5i3 123 25 resulting result VBG cord-005902-5zuij5i3 123 26 in in IN cord-005902-5zuij5i3 123 27 an an DT cord-005902-5zuij5i3 123 28 increased increase VBN cord-005902-5zuij5i3 123 29 tissue tissue NN cord-005902-5zuij5i3 123 30 perfusion perfusion NN cord-005902-5zuij5i3 123 31 / / SYM cord-005902-5zuij5i3 123 32 microcirculation microcirculation NN cord-005902-5zuij5i3 123 33 [ [ -LRB- cord-005902-5zuij5i3 123 34 28 28 CD cord-005902-5zuij5i3 123 35 ] ] -RRB- cord-005902-5zuij5i3 123 36 [ [ -LRB- cord-005902-5zuij5i3 123 37 29 29 CD cord-005902-5zuij5i3 123 38 ] ] -RRB- cord-005902-5zuij5i3 123 39 [ [ -LRB- cord-005902-5zuij5i3 123 40 30 30 CD cord-005902-5zuij5i3 123 41 ] ] -RRB- cord-005902-5zuij5i3 123 42 . . . cord-005902-5zuij5i3 124 1 Another another DT cord-005902-5zuij5i3 124 2 important important JJ cord-005902-5zuij5i3 124 3 effect effect NN cord-005902-5zuij5i3 124 4 , , , cord-005902-5zuij5i3 124 5 thought think VBN cord-005902-5zuij5i3 124 6 to to TO cord-005902-5zuij5i3 124 7 be be VB cord-005902-5zuij5i3 124 8 helpful helpful JJ cord-005902-5zuij5i3 124 9 in in IN cord-005902-5zuij5i3 124 10 treating treat VBG cord-005902-5zuij5i3 124 11 NF nf NN cord-005902-5zuij5i3 124 12 by by IN cord-005902-5zuij5i3 124 13 improving improve VBG cord-005902-5zuij5i3 124 14 host host NN cord-005902-5zuij5i3 124 15 defense defense NN cord-005902-5zuij5i3 124 16 , , , cord-005902-5zuij5i3 124 17 is be VBZ cord-005902-5zuij5i3 124 18 the the DT cord-005902-5zuij5i3 124 19 activation activation NN cord-005902-5zuij5i3 124 20 of of IN cord-005902-5zuij5i3 124 21 leukocytes leukocyte NNS cord-005902-5zuij5i3 124 22 . . . cord-005902-5zuij5i3 125 1 Also also RB cord-005902-5zuij5i3 125 2 reparative reparative JJ cord-005902-5zuij5i3 125 3 processes process NNS cord-005902-5zuij5i3 125 4 might may MD cord-005902-5zuij5i3 125 5 be be VB cord-005902-5zuij5i3 125 6 stimulated stimulate VBN cord-005902-5zuij5i3 125 7 due due IN cord-005902-5zuij5i3 125 8 to to IN cord-005902-5zuij5i3 125 9 fibroblast fibroblast NN cord-005902-5zuij5i3 125 10 migration migration NN cord-005902-5zuij5i3 125 11 , , , cord-005902-5zuij5i3 125 12 proliferation proliferation NN cord-005902-5zuij5i3 125 13 and and CC cord-005902-5zuij5i3 125 14 collagen collagen NN cord-005902-5zuij5i3 125 15 synthesis synthesis NN cord-005902-5zuij5i3 125 16 [ [ -LRB- cord-005902-5zuij5i3 125 17 22 22 CD cord-005902-5zuij5i3 125 18 , , , cord-005902-5zuij5i3 125 19 31 31 CD cord-005902-5zuij5i3 125 20 , , , cord-005902-5zuij5i3 125 21 32 32 CD cord-005902-5zuij5i3 125 22 ] ] -RRB- cord-005902-5zuij5i3 125 23 . . . cord-005902-5zuij5i3 126 1 These these DT cord-005902-5zuij5i3 126 2 effects effect NNS cord-005902-5zuij5i3 126 3 might may MD cord-005902-5zuij5i3 126 4 be be VB cord-005902-5zuij5i3 126 5 very very RB cord-005902-5zuij5i3 126 6 helpful helpful JJ cord-005902-5zuij5i3 126 7 to to TO cord-005902-5zuij5i3 126 8 support support VB cord-005902-5zuij5i3 126 9 healing healing NN cord-005902-5zuij5i3 126 10 / / SYM cord-005902-5zuij5i3 126 11 granulation granulation NN cord-005902-5zuij5i3 126 12 tissue tissue NN cord-005902-5zuij5i3 126 13 formation formation NN cord-005902-5zuij5i3 126 14 of of IN cord-005902-5zuij5i3 126 15 these these DT cord-005902-5zuij5i3 126 16 mostly mostly RB cord-005902-5zuij5i3 126 17 difficult difficult JJ cord-005902-5zuij5i3 126 18 wounds wound NNS cord-005902-5zuij5i3 126 19 [ [ -LRB- cord-005902-5zuij5i3 126 20 33 33 CD cord-005902-5zuij5i3 126 21 ] ] -RRB- cord-005902-5zuij5i3 126 22 . . . cord-005902-5zuij5i3 127 1 Various various JJ cord-005902-5zuij5i3 127 2 treatment treatment NN cord-005902-5zuij5i3 127 3 regimes regime NNS cord-005902-5zuij5i3 127 4 are be VBP cord-005902-5zuij5i3 127 5 recommended recommend VBN cord-005902-5zuij5i3 127 6 to to TO cord-005902-5zuij5i3 127 7 be be VB cord-005902-5zuij5i3 127 8 followed follow VBN cord-005902-5zuij5i3 127 9 - - HYPH cord-005902-5zuij5i3 127 10 up up NN cord-005902-5zuij5i3 127 11 ; ; : cord-005902-5zuij5i3 127 12 however however RB cord-005902-5zuij5i3 127 13 the the DT cord-005902-5zuij5i3 127 14 most most RBS cord-005902-5zuij5i3 127 15 intense intense JJ cord-005902-5zuij5i3 127 16 is be VBZ cord-005902-5zuij5i3 127 17 that that IN cord-005902-5zuij5i3 127 18 in in IN cord-005902-5zuij5i3 127 19 accordance accordance NN cord-005902-5zuij5i3 127 20 with with IN cord-005902-5zuij5i3 127 21 crush crush NN cord-005902-5zuij5i3 127 22 injury injury NN cord-005902-5zuij5i3 127 23 with with IN cord-005902-5zuij5i3 127 24 three three CD cord-005902-5zuij5i3 127 25 treatments treatment NNS cord-005902-5zuij5i3 127 26 within within IN cord-005902-5zuij5i3 127 27 the the DT cord-005902-5zuij5i3 127 28 first first JJ cord-005902-5zuij5i3 127 29 48 48 CD cord-005902-5zuij5i3 127 30 hours hour NNS cord-005902-5zuij5i3 127 31 ( ( -LRB- cord-005902-5zuij5i3 127 32 2 2 CD cord-005902-5zuij5i3 127 33 - - SYM cord-005902-5zuij5i3 127 34 2.5 2.5 CD cord-005902-5zuij5i3 127 35 ATA ATA NNP cord-005902-5zuij5i3 127 36 , , , cord-005902-5zuij5i3 127 37 1 1 CD cord-005902-5zuij5i3 127 38 - - SYM cord-005902-5zuij5i3 127 39 2 2 CD cord-005902-5zuij5i3 127 40 h h NN cord-005902-5zuij5i3 127 41 O o NN cord-005902-5zuij5i3 127 42 2breathing 2breathing NN cord-005902-5zuij5i3 127 43 ) ) -RRB- cord-005902-5zuij5i3 127 44 , , , cord-005902-5zuij5i3 127 45 followed follow VBN cord-005902-5zuij5i3 127 46 by by IN cord-005902-5zuij5i3 127 47 two two CD cord-005902-5zuij5i3 127 48 treatments treatment NNS cord-005902-5zuij5i3 127 49 the the DT cord-005902-5zuij5i3 127 50 next next JJ cord-005902-5zuij5i3 127 51 48 48 CD cord-005902-5zuij5i3 127 52 h h NN cord-005902-5zuij5i3 127 53 and and CC cord-005902-5zuij5i3 127 54 finally finally RB cord-005902-5zuij5i3 127 55 48 48 CD cord-005902-5zuij5i3 127 56 h h NN cord-005902-5zuij5i3 127 57 once once RB cord-005902-5zuij5i3 127 58 a a DT cord-005902-5zuij5i3 127 59 day day NN cord-005902-5zuij5i3 127 60 . . . cord-005902-5zuij5i3 128 1 Since since IN cord-005902-5zuij5i3 128 2 the the DT cord-005902-5zuij5i3 128 3 use use NN cord-005902-5zuij5i3 128 4 of of IN cord-005902-5zuij5i3 128 5 HBOtreatment HBOtreatment NNP cord-005902-5zuij5i3 128 6 is be VBZ cord-005902-5zuij5i3 128 7 connected connect VBN cord-005902-5zuij5i3 128 8 with with IN cord-005902-5zuij5i3 128 9 high high JJ cord-005902-5zuij5i3 128 10 medical medical JJ cord-005902-5zuij5i3 128 11 and and CC cord-005902-5zuij5i3 128 12 technical technical JJ cord-005902-5zuij5i3 128 13 expenditure expenditure NN cord-005902-5zuij5i3 128 14 , , , cord-005902-5zuij5i3 128 15 especially especially RB cord-005902-5zuij5i3 128 16 if if IN cord-005902-5zuij5i3 128 17 the the DT cord-005902-5zuij5i3 128 18 patient patient NN cord-005902-5zuij5i3 128 19 is be VBZ cord-005902-5zuij5i3 128 20 critically critically RB cord-005902-5zuij5i3 128 21 ill ill JJ cord-005902-5zuij5i3 128 22 due due IN cord-005902-5zuij5i3 128 23 to to IN cord-005902-5zuij5i3 128 24 sepsis sepsis NN cord-005902-5zuij5i3 128 25 and and CC cord-005902-5zuij5i3 128 26 needs need VBZ cord-005902-5zuij5i3 128 27 breathing breathe VBG cord-005902-5zuij5i3 128 28 support support NN cord-005902-5zuij5i3 128 29 , , , cord-005902-5zuij5i3 128 30 estimation estimation NN cord-005902-5zuij5i3 128 31 is be VBZ cord-005902-5zuij5i3 128 32 necessary necessary JJ cord-005902-5zuij5i3 128 33 , , , cord-005902-5zuij5i3 128 34 also also RB cord-005902-5zuij5i3 128 35 the the DT cord-005902-5zuij5i3 128 36 literature literature NN cord-005902-5zuij5i3 128 37 is be VBZ cord-005902-5zuij5i3 128 38 controversial controversial JJ cord-005902-5zuij5i3 128 39 about about IN cord-005902-5zuij5i3 128 40 the the DT cord-005902-5zuij5i3 128 41 effects effect NNS cord-005902-5zuij5i3 128 42 on on IN cord-005902-5zuij5i3 128 43 morbidity morbidity NN cord-005902-5zuij5i3 128 44 and and CC cord-005902-5zuij5i3 128 45 mortality mortality NN cord-005902-5zuij5i3 128 46 rates rate NNS cord-005902-5zuij5i3 128 47 [ [ -LRB- cord-005902-5zuij5i3 128 48 12 12 CD cord-005902-5zuij5i3 128 49 , , , cord-005902-5zuij5i3 128 50 34 34 CD cord-005902-5zuij5i3 128 51 , , , cord-005902-5zuij5i3 128 52 35 35 CD cord-005902-5zuij5i3 128 53 ] ] -RRB- cord-005902-5zuij5i3 128 54 . . . cord-005902-5zuij5i3 129 1 However however RB cord-005902-5zuij5i3 129 2 , , , cord-005902-5zuij5i3 129 3 this this DT cord-005902-5zuij5i3 129 4 therapy therapy NN cord-005902-5zuij5i3 129 5 needs need VBZ cord-005902-5zuij5i3 129 6 to to TO cord-005902-5zuij5i3 129 7 be be VB cord-005902-5zuij5i3 129 8 considered consider VBN cord-005902-5zuij5i3 129 9 focusing focus VBG cord-005902-5zuij5i3 129 10 an an DT cord-005902-5zuij5i3 129 11 increasing increase VBG cord-005902-5zuij5i3 129 12 network network NN cord-005902-5zuij5i3 129 13 and and CC cord-005902-5zuij5i3 129 14 therapeutic therapeutic JJ cord-005902-5zuij5i3 129 15 standard standard NN cord-005902-5zuij5i3 129 16 in in IN cord-005902-5zuij5i3 129 17 HBO HBO NNP cord-005902-5zuij5i3 129 18 - - HYPH cord-005902-5zuij5i3 129 19 Treatment Treatment NNP cord-005902-5zuij5i3 129 20 . . . cord-005902-5zuij5i3 130 1 Another another DT cord-005902-5zuij5i3 130 2 possibility possibility NN cord-005902-5zuij5i3 130 3 to to TO cord-005902-5zuij5i3 130 4 increase increase VB cord-005902-5zuij5i3 130 5 oxygen oxygen NN cord-005902-5zuij5i3 130 6 in in IN cord-005902-5zuij5i3 130 7 the the DT cord-005902-5zuij5i3 130 8 body body NN cord-005902-5zuij5i3 130 9 is be VBZ cord-005902-5zuij5i3 130 10 an an DT cord-005902-5zuij5i3 130 11 intravenous intravenous JJ cord-005902-5zuij5i3 130 12 application application NN cord-005902-5zuij5i3 130 13 ( ( -LRB- cord-005902-5zuij5i3 130 14 Regelsberger Regelsberger NNP cord-005902-5zuij5i3 130 15 's 's POS cord-005902-5zuij5i3 130 16 intravenous intravenous JJ cord-005902-5zuij5i3 130 17 Oxygen Oxygen NNP cord-005902-5zuij5i3 130 18 Therapy Therapy NNP cord-005902-5zuij5i3 130 19 ) ) -RRB- cord-005902-5zuij5i3 130 20 . . . cord-005902-5zuij5i3 131 1 However however RB cord-005902-5zuij5i3 131 2 the the DT cord-005902-5zuij5i3 131 3 effect effect NN cord-005902-5zuij5i3 131 4 needs need VBZ cord-005902-5zuij5i3 131 5 to to TO cord-005902-5zuij5i3 131 6 be be VB cord-005902-5zuij5i3 131 7 proved prove VBN cord-005902-5zuij5i3 131 8 for for IN cord-005902-5zuij5i3 131 9 NF nf NN cord-005902-5zuij5i3 131 10 , , , cord-005902-5zuij5i3 131 11 also also RB cord-005902-5zuij5i3 131 12 with with IN cord-005902-5zuij5i3 131 13 respect respect NN cord-005902-5zuij5i3 131 14 to to IN cord-005902-5zuij5i3 131 15 an an DT cord-005902-5zuij5i3 131 16 increase increase NN cord-005902-5zuij5i3 131 17 of of IN cord-005902-5zuij5i3 131 18 granulocytes granulocyte NNS cord-005902-5zuij5i3 131 19 [ [ -LRB- cord-005902-5zuij5i3 131 20 36 36 CD cord-005902-5zuij5i3 131 21 ] ] -RRB- cord-005902-5zuij5i3 131 22 . . . cord-005902-5zuij5i3 132 1 Therefore therefore RB cord-005902-5zuij5i3 132 2 the the DT cord-005902-5zuij5i3 132 3 major major JJ cord-005902-5zuij5i3 132 4 focus focus NN cord-005902-5zuij5i3 132 5 in in IN cord-005902-5zuij5i3 132 6 NF nf NN cord-005902-5zuij5i3 132 7 should should MD cord-005902-5zuij5i3 132 8 be be VB cord-005902-5zuij5i3 132 9 related relate VBN cord-005902-5zuij5i3 132 10 to to IN cord-005902-5zuij5i3 132 11 intensive intensive JJ cord-005902-5zuij5i3 132 12 care care NN cord-005902-5zuij5i3 132 13 management management NN cord-005902-5zuij5i3 132 14 and and CC cord-005902-5zuij5i3 132 15 the the DT cord-005902-5zuij5i3 132 16 vital vital JJ cord-005902-5zuij5i3 132 17 surgical surgical JJ cord-005902-5zuij5i3 132 18 therapy therapy NN cord-005902-5zuij5i3 132 19 with with IN cord-005902-5zuij5i3 132 20 no no DT cord-005902-5zuij5i3 132 21 delay delay NN cord-005902-5zuij5i3 132 22 . . . cord-005902-5zuij5i3 133 1 After after IN cord-005902-5zuij5i3 133 2 primary primary JJ cord-005902-5zuij5i3 133 3 surgical surgical JJ cord-005902-5zuij5i3 133 4 treatment treatment NN cord-005902-5zuij5i3 133 5 in in IN cord-005902-5zuij5i3 133 6 most most JJS cord-005902-5zuij5i3 133 7 cases case NNS cord-005902-5zuij5i3 133 8 a a DT cord-005902-5zuij5i3 133 9 topical topical JJ cord-005902-5zuij5i3 133 10 wound wound NN cord-005902-5zuij5i3 133 11 treatment treatment NN cord-005902-5zuij5i3 133 12 is be VBZ cord-005902-5zuij5i3 133 13 used use VBN cord-005902-5zuij5i3 133 14 . . . cord-005902-5zuij5i3 134 1 Various various JJ cord-005902-5zuij5i3 134 2 substances substance NNS cord-005902-5zuij5i3 134 3 according accord VBG cord-005902-5zuij5i3 134 4 to to IN cord-005902-5zuij5i3 134 5 the the DT cord-005902-5zuij5i3 134 6 isolated isolate VBN cord-005902-5zuij5i3 134 7 bacteria bacteria NNS cord-005902-5zuij5i3 134 8 can can MD cord-005902-5zuij5i3 134 9 be be VB cord-005902-5zuij5i3 134 10 chosen choose VBN cord-005902-5zuij5i3 134 11 . . . cord-005902-5zuij5i3 135 1 Mostly mostly RB cord-005902-5zuij5i3 135 2 the the DT cord-005902-5zuij5i3 135 3 following following JJ cord-005902-5zuij5i3 135 4 antiseptic antiseptic JJ cord-005902-5zuij5i3 135 5 substances substance NNS cord-005902-5zuij5i3 135 6 are be VBP cord-005902-5zuij5i3 135 7 recommended recommend VBN cord-005902-5zuij5i3 135 8 : : : cord-005902-5zuij5i3 135 9 Polyhexamid Polyhexamid NNP cord-005902-5zuij5i3 135 10 , , , cord-005902-5zuij5i3 135 11 Povidon Povidon NNP cord-005902-5zuij5i3 135 12 - - HYPH cord-005902-5zuij5i3 135 13 Iodine iodine NN cord-005902-5zuij5i3 135 14 , , , cord-005902-5zuij5i3 135 15 Silver Silver NNP cord-005902-5zuij5i3 135 16 Sulfadiazine Sulfadiazine NNP cord-005902-5zuij5i3 135 17 , , , cord-005902-5zuij5i3 135 18 Actate Actate NNP cord-005902-5zuij5i3 135 19 Mafenid Mafenid NNP cord-005902-5zuij5i3 135 20 . . . cord-005902-5zuij5i3 136 1 Also also RB cord-005902-5zuij5i3 136 2 wine wine NN cord-005902-5zuij5i3 136 3 vinegar vinegar NN cord-005902-5zuij5i3 136 4 and and CC cord-005902-5zuij5i3 136 5 citric citric NN cord-005902-5zuij5i3 136 6 acid acid NN cord-005902-5zuij5i3 136 7 have have VBP cord-005902-5zuij5i3 136 8 been be VBN cord-005902-5zuij5i3 136 9 applied apply VBN cord-005902-5zuij5i3 136 10 , , , cord-005902-5zuij5i3 136 11 especially especially RB cord-005902-5zuij5i3 136 12 to to TO cord-005902-5zuij5i3 136 13 modify modify VB cord-005902-5zuij5i3 136 14 the the DT cord-005902-5zuij5i3 136 15 wound wound NN cord-005902-5zuij5i3 136 16 environment environment NN cord-005902-5zuij5i3 136 17 and and CC cord-005902-5zuij5i3 136 18 lower lower VB cord-005902-5zuij5i3 136 19 the the DT cord-005902-5zuij5i3 136 20 pH ph NN cord-005902-5zuij5i3 136 21 in in IN cord-005902-5zuij5i3 136 22 cases case NNS cord-005902-5zuij5i3 136 23 of of IN cord-005902-5zuij5i3 136 24 pseudomonas pseudomonas NN cord-005902-5zuij5i3 136 25 infections infection NNS cord-005902-5zuij5i3 136 26 . . . cord-005902-5zuij5i3 137 1 Vacuum Vacuum NNP cord-005902-5zuij5i3 137 2 Sealing Sealing NNP cord-005902-5zuij5i3 137 3 is be VBZ cord-005902-5zuij5i3 137 4 a a DT cord-005902-5zuij5i3 137 5 widely widely RB cord-005902-5zuij5i3 137 6 used use VBN cord-005902-5zuij5i3 137 7 approach approach NN cord-005902-5zuij5i3 137 8 to to IN cord-005902-5zuij5i3 137 9 condition condition NN cord-005902-5zuij5i3 137 10 destroyed destroy VBD cord-005902-5zuij5i3 137 11 soft soft JJ cord-005902-5zuij5i3 137 12 tissue tissue NN cord-005902-5zuij5i3 137 13 in in IN cord-005902-5zuij5i3 137 14 order order NN cord-005902-5zuij5i3 137 15 to to TO cord-005902-5zuij5i3 137 16 allow allow VB cord-005902-5zuij5i3 137 17 granulation granulation NN cord-005902-5zuij5i3 137 18 and and CC cord-005902-5zuij5i3 137 19 a a DT cord-005902-5zuij5i3 137 20 safe safe JJ cord-005902-5zuij5i3 137 21 secondary secondary JJ cord-005902-5zuij5i3 137 22 reconstruction reconstruction NN cord-005902-5zuij5i3 137 23 [ [ -LRB- cord-005902-5zuij5i3 137 24 37 37 CD cord-005902-5zuij5i3 137 25 ] ] -RRB- cord-005902-5zuij5i3 137 26 . . . cord-005902-5zuij5i3 138 1 It -PRON- PRP cord-005902-5zuij5i3 138 2 is be VBZ cord-005902-5zuij5i3 138 3 extremely extremely RB cord-005902-5zuij5i3 138 4 useful useful JJ cord-005902-5zuij5i3 138 5 in in IN cord-005902-5zuij5i3 138 6 cleaned clean VBN cord-005902-5zuij5i3 138 7 wounds wound NNS cord-005902-5zuij5i3 138 8 of of IN cord-005902-5zuij5i3 138 9 the the DT cord-005902-5zuij5i3 138 10 extremities extremity NNS cord-005902-5zuij5i3 138 11 and and CC cord-005902-5zuij5i3 138 12 the the DT cord-005902-5zuij5i3 138 13 abdomen abdomen NN cord-005902-5zuij5i3 138 14 and and CC cord-005902-5zuij5i3 138 15 reduces reduce VBZ cord-005902-5zuij5i3 138 16 surgical surgical JJ cord-005902-5zuij5i3 138 17 interventions intervention NNS cord-005902-5zuij5i3 138 18 to to IN cord-005902-5zuij5i3 138 19 intervals interval NNS cord-005902-5zuij5i3 138 20 between between IN cord-005902-5zuij5i3 138 21 2 2 CD cord-005902-5zuij5i3 138 22 and and CC cord-005902-5zuij5i3 138 23 5 5 CD cord-005902-5zuij5i3 138 24 days day NNS cord-005902-5zuij5i3 138 25 . . . cord-005902-5zuij5i3 139 1 In in IN cord-005902-5zuij5i3 139 2 acute acute JJ cord-005902-5zuij5i3 139 3 stages stage NNS cord-005902-5zuij5i3 139 4 of of IN cord-005902-5zuij5i3 139 5 necrotizing necrotize VBG cord-005902-5zuij5i3 139 6 fasciitis fasciitis NN cord-005902-5zuij5i3 139 7 , , , cord-005902-5zuij5i3 139 8 however however RB cord-005902-5zuij5i3 139 9 , , , cord-005902-5zuij5i3 139 10 vacuum vacuum NN cord-005902-5zuij5i3 139 11 sealing sealing NN cord-005902-5zuij5i3 139 12 is be VBZ cord-005902-5zuij5i3 139 13 not not RB cord-005902-5zuij5i3 139 14 indicated indicate VBN cord-005902-5zuij5i3 139 15 during during IN cord-005902-5zuij5i3 139 16 the the DT cord-005902-5zuij5i3 139 17 early early JJ cord-005902-5zuij5i3 139 18 states state NNS cord-005902-5zuij5i3 139 19 of of IN cord-005902-5zuij5i3 139 20 purulent purulent JJ cord-005902-5zuij5i3 139 21 infections infection NNS cord-005902-5zuij5i3 139 22 and and CC cord-005902-5zuij5i3 139 23 infected infect VBN cord-005902-5zuij5i3 139 24 tissue tissue NN cord-005902-5zuij5i3 139 25 necrosis necrosis NN cord-005902-5zuij5i3 139 26 . . . cord-005902-5zuij5i3 140 1 But but CC cord-005902-5zuij5i3 140 2 subsequently subsequently RB cord-005902-5zuij5i3 140 3 , , , cord-005902-5zuij5i3 140 4 when when WRB cord-005902-5zuij5i3 140 5 infected infect VBN cord-005902-5zuij5i3 140 6 and and CC cord-005902-5zuij5i3 140 7 destroyed destroy VBD cord-005902-5zuij5i3 140 8 soft soft JJ cord-005902-5zuij5i3 140 9 tissues tissue NNS cord-005902-5zuij5i3 140 10 have have VBP cord-005902-5zuij5i3 140 11 been be VBN cord-005902-5zuij5i3 140 12 removed remove VBN cord-005902-5zuij5i3 140 13 , , , cord-005902-5zuij5i3 140 14 vacuum vacuum NN cord-005902-5zuij5i3 140 15 sealing sealing NN cord-005902-5zuij5i3 140 16 seems seem VBZ cord-005902-5zuij5i3 140 17 to to TO cord-005902-5zuij5i3 140 18 be be VB cord-005902-5zuij5i3 140 19 very very RB cord-005902-5zuij5i3 140 20 useful useful JJ cord-005902-5zuij5i3 140 21 for for IN cord-005902-5zuij5i3 140 22 conditioning condition VBG cord-005902-5zuij5i3 140 23 the the DT cord-005902-5zuij5i3 140 24 defects defect NNS cord-005902-5zuij5i3 140 25 and and CC cord-005902-5zuij5i3 140 26 occasionally occasionally RB cord-005902-5zuij5i3 140 27 allowing allow VBG cord-005902-5zuij5i3 140 28 limited limited JJ cord-005902-5zuij5i3 140 29 tissue tissue NN cord-005902-5zuij5i3 140 30 closure closure NN cord-005902-5zuij5i3 140 31 using use VBG cord-005902-5zuij5i3 140 32 skin skin NN cord-005902-5zuij5i3 140 33 graft graft NN cord-005902-5zuij5i3 140 34 ; ; : cord-005902-5zuij5i3 140 35 if if IN cord-005902-5zuij5i3 140 36 not not RB cord-005902-5zuij5i3 140 37 , , , cord-005902-5zuij5i3 140 38 a a DT cord-005902-5zuij5i3 140 39 complex complex JJ cord-005902-5zuij5i3 140 40 reconstruction reconstruction NN cord-005902-5zuij5i3 140 41 is be VBZ cord-005902-5zuij5i3 140 42 required require VBN cord-005902-5zuij5i3 140 43 [ [ -LRB- cord-005902-5zuij5i3 140 44 38 38 CD cord-005902-5zuij5i3 140 45 ] ] -RRB- cord-005902-5zuij5i3 140 46 . . . cord-005902-5zuij5i3 141 1 The the DT cord-005902-5zuij5i3 141 2 clinical clinical JJ cord-005902-5zuij5i3 141 3 cases case NNS cord-005902-5zuij5i3 141 4 with with IN cord-005902-5zuij5i3 141 5 NF nf NN cord-005902-5zuij5i3 141 6 and and CC cord-005902-5zuij5i3 141 7 primary primary JJ cord-005902-5zuij5i3 141 8 focus focus NN cord-005902-5zuij5i3 141 9 on on IN cord-005902-5zuij5i3 141 10 the the DT cord-005902-5zuij5i3 141 11 extremities extremity NNS cord-005902-5zuij5i3 141 12 are be VBP cord-005902-5zuij5i3 141 13 listed list VBN cord-005902-5zuij5i3 141 14 in in IN cord-005902-5zuij5i3 141 15 Tables Tables NNPS cord-005902-5zuij5i3 141 16 6 6 CD cord-005902-5zuij5i3 141 17 and and CC cord-005902-5zuij5i3 141 18 7 7 CD cord-005902-5zuij5i3 141 19 . . . cord-005902-5zuij5i3 142 1 Most Most JJS cord-005902-5zuij5i3 142 2 of of IN cord-005902-5zuij5i3 142 3 these these DT cord-005902-5zuij5i3 142 4 have have VBP cord-005902-5zuij5i3 142 5 had have VBN cord-005902-5zuij5i3 142 6 minor minor JJ cord-005902-5zuij5i3 142 7 injuries injury NNS cord-005902-5zuij5i3 142 8 with with IN cord-005902-5zuij5i3 142 9 rapid rapid JJ cord-005902-5zuij5i3 142 10 spreading spreading NN cord-005902-5zuij5i3 142 11 of of IN cord-005902-5zuij5i3 142 12 the the DT cord-005902-5zuij5i3 142 13 infection infection NN cord-005902-5zuij5i3 142 14 . . . cord-005902-5zuij5i3 143 1 One one CD cord-005902-5zuij5i3 143 2 exemplary exemplary JJ cord-005902-5zuij5i3 143 3 case case NN cord-005902-5zuij5i3 143 4 is be VBZ cord-005902-5zuij5i3 143 5 described describe VBN cord-005902-5zuij5i3 143 6 to to TO cord-005902-5zuij5i3 143 7 illustrate illustrate VB cord-005902-5zuij5i3 143 8 the the DT cord-005902-5zuij5i3 143 9 significance significance NN cord-005902-5zuij5i3 143 10 of of IN cord-005902-5zuij5i3 143 11 early early JJ cord-005902-5zuij5i3 143 12 operative operative JJ cord-005902-5zuij5i3 143 13 treatment treatment NN cord-005902-5zuij5i3 143 14 and and CC cord-005902-5zuij5i3 143 15 excision excision NN cord-005902-5zuij5i3 143 16 of of IN cord-005902-5zuij5i3 143 17 the the DT cord-005902-5zuij5i3 143 18 devastated devastated JJ cord-005902-5zuij5i3 143 19 tissue tissue NN cord-005902-5zuij5i3 143 20 . . . cord-005902-5zuij5i3 144 1 A a DT cord-005902-5zuij5i3 144 2 52-year 52-year JJ cord-005902-5zuij5i3 144 3 - - HYPH cord-005902-5zuij5i3 144 4 old old JJ cord-005902-5zuij5i3 144 5 gentleman gentleman NN cord-005902-5zuij5i3 144 6 was be VBD cord-005902-5zuij5i3 144 7 visiting visit VBG cord-005902-5zuij5i3 144 8 a a DT cord-005902-5zuij5i3 144 9 garden garden NN cord-005902-5zuij5i3 144 10 market market NN cord-005902-5zuij5i3 144 11 . . . cord-005902-5zuij5i3 145 1 By by IN cord-005902-5zuij5i3 145 2 lifting lift VBG cord-005902-5zuij5i3 145 3 various various JJ cord-005902-5zuij5i3 145 4 flowers flower NNS cord-005902-5zuij5i3 145 5 , , , cord-005902-5zuij5i3 145 6 He -PRON- PRP cord-005902-5zuij5i3 145 7 experienced experience VBD cord-005902-5zuij5i3 145 8 a a DT cord-005902-5zuij5i3 145 9 minor minor JJ cord-005902-5zuij5i3 145 10 scratch scratch NN cord-005902-5zuij5i3 145 11 , , , cord-005902-5zuij5i3 145 12 while while IN cord-005902-5zuij5i3 145 13 handling handle VBG cord-005902-5zuij5i3 145 14 various various JJ cord-005902-5zuij5i3 145 15 flowers flower NNS cord-005902-5zuij5i3 145 16 , , , cord-005902-5zuij5i3 145 17 on on IN cord-005902-5zuij5i3 145 18 the the DT cord-005902-5zuij5i3 145 19 ulna ulna NN cord-005902-5zuij5i3 145 20 side side NN cord-005902-5zuij5i3 145 21 at at IN cord-005902-5zuij5i3 145 22 the the DT cord-005902-5zuij5i3 145 23 middle middle JJ cord-005902-5zuij5i3 145 24 phalanx phalanx NN cord-005902-5zuij5i3 145 25 of of IN cord-005902-5zuij5i3 145 26 the the DT cord-005902-5zuij5i3 145 27 left left JJ cord-005902-5zuij5i3 145 28 ring ring NN cord-005902-5zuij5i3 145 29 finger finger NN cord-005902-5zuij5i3 145 30 . . . cord-005902-5zuij5i3 146 1 This this DT cord-005902-5zuij5i3 146 2 happened happen VBD cord-005902-5zuij5i3 146 3 on on IN cord-005902-5zuij5i3 146 4 a a DT cord-005902-5zuij5i3 146 5 Thursday Thursday NNP cord-005902-5zuij5i3 146 6 afternoon afternoon NN cord-005902-5zuij5i3 146 7 and and CC cord-005902-5zuij5i3 146 8 since since IN cord-005902-5zuij5i3 146 9 there there EX cord-005902-5zuij5i3 146 10 was be VBD cord-005902-5zuij5i3 146 11 no no DT cord-005902-5zuij5i3 146 12 obvious obvious JJ cord-005902-5zuij5i3 146 13 skin skin NN cord-005902-5zuij5i3 146 14 lesion lesion NN cord-005902-5zuij5i3 146 15 he -PRON- PRP cord-005902-5zuij5i3 146 16 did do VBD cord-005902-5zuij5i3 146 17 not not RB cord-005902-5zuij5i3 146 18 care care VB cord-005902-5zuij5i3 146 19 about about IN cord-005902-5zuij5i3 146 20 it -PRON- PRP cord-005902-5zuij5i3 146 21 . . . cord-005902-5zuij5i3 147 1 During during IN cord-005902-5zuij5i3 147 2 the the DT cord-005902-5zuij5i3 147 3 next next JJ cord-005902-5zuij5i3 147 4 night night NN cord-005902-5zuij5i3 147 5 and and CC cord-005902-5zuij5i3 147 6 day day NN cord-005902-5zuij5i3 147 7 he -PRON- PRP cord-005902-5zuij5i3 147 8 experienced experience VBD cord-005902-5zuij5i3 147 9 increasing increase VBG cord-005902-5zuij5i3 147 10 swelling swelling NN cord-005902-5zuij5i3 147 11 and and CC cord-005902-5zuij5i3 147 12 pain pain NN cord-005902-5zuij5i3 147 13 of of IN cord-005902-5zuij5i3 147 14 the the DT cord-005902-5zuij5i3 147 15 whole whole JJ cord-005902-5zuij5i3 147 16 hand hand NN cord-005902-5zuij5i3 147 17 -not -not : cord-005902-5zuij5i3 147 18 only only RB cord-005902-5zuij5i3 147 19 the the DT cord-005902-5zuij5i3 147 20 finger finger NN cord-005902-5zuij5i3 147 21 . . . cord-005902-5zuij5i3 148 1 On on IN cord-005902-5zuij5i3 148 2 Saturday Saturday NNP cord-005902-5zuij5i3 148 3 morning morning NN cord-005902-5zuij5i3 148 4 he -PRON- PRP cord-005902-5zuij5i3 148 5 consulted consult VBD cord-005902-5zuij5i3 148 6 a a DT cord-005902-5zuij5i3 148 7 local local JJ cord-005902-5zuij5i3 148 8 surgeon surgeon NN cord-005902-5zuij5i3 148 9 , , , cord-005902-5zuij5i3 148 10 who who WP cord-005902-5zuij5i3 148 11 admitted admit VBD cord-005902-5zuij5i3 148 12 him -PRON- PRP cord-005902-5zuij5i3 148 13 immediately immediately RB cord-005902-5zuij5i3 148 14 to to IN cord-005902-5zuij5i3 148 15 the the DT cord-005902-5zuij5i3 148 16 hospital hospital NN cord-005902-5zuij5i3 148 17 . . . cord-005902-5zuij5i3 149 1 The the DT cord-005902-5zuij5i3 149 2 patient patient NN cord-005902-5zuij5i3 149 3 had have VBD cord-005902-5zuij5i3 149 4 already already RB cord-005902-5zuij5i3 149 5 clear clear JJ cord-005902-5zuij5i3 149 6 signs sign NNS cord-005902-5zuij5i3 149 7 of of IN cord-005902-5zuij5i3 149 8 local local JJ cord-005902-5zuij5i3 149 9 infection infection NN cord-005902-5zuij5i3 149 10 ( ( -LRB- cord-005902-5zuij5i3 149 11 Figure figure NN cord-005902-5zuij5i3 149 12 3 3 CD cord-005902-5zuij5i3 149 13 ) ) -RRB- cord-005902-5zuij5i3 149 14 , , , cord-005902-5zuij5i3 149 15 systemic systemic JJ cord-005902-5zuij5i3 149 16 sepsis sepsis NN cord-005902-5zuij5i3 149 17 with with IN cord-005902-5zuij5i3 149 18 reduced reduce VBN cord-005902-5zuij5i3 149 19 blood blood NN cord-005902-5zuij5i3 149 20 pressure pressure NN cord-005902-5zuij5i3 149 21 , , , cord-005902-5zuij5i3 149 22 tachycardia tachycardia NN cord-005902-5zuij5i3 149 23 and and CC cord-005902-5zuij5i3 149 24 fever fever NN cord-005902-5zuij5i3 149 25 up up IN cord-005902-5zuij5i3 149 26 to to TO cord-005902-5zuij5i3 149 27 40 40 CD cord-005902-5zuij5i3 149 28 ° ° NN cord-005902-5zuij5i3 149 29 C c NN cord-005902-5zuij5i3 149 30 . . . cord-005902-5zuij5i3 150 1 Immediately immediately RB cord-005902-5zuij5i3 150 2 , , , cord-005902-5zuij5i3 150 3 he -PRON- PRP cord-005902-5zuij5i3 150 4 was be VBD cord-005902-5zuij5i3 150 5 brought bring VBN cord-005902-5zuij5i3 150 6 to to IN cord-005902-5zuij5i3 150 7 the the DT cord-005902-5zuij5i3 150 8 surgery surgery NN cord-005902-5zuij5i3 150 9 room room NN cord-005902-5zuij5i3 150 10 where where WRB cord-005902-5zuij5i3 150 11 a a DT cord-005902-5zuij5i3 150 12 primary primary JJ cord-005902-5zuij5i3 150 13 excision excision NN cord-005902-5zuij5i3 150 14 of of IN cord-005902-5zuij5i3 150 15 the the DT cord-005902-5zuij5i3 150 16 possibly possibly RB cord-005902-5zuij5i3 150 17 involved involved JJ cord-005902-5zuij5i3 150 18 tissue tissue NN cord-005902-5zuij5i3 150 19 was be VBD cord-005902-5zuij5i3 150 20 done do VBN cord-005902-5zuij5i3 150 21 , , , cord-005902-5zuij5i3 150 22 up up IN cord-005902-5zuij5i3 150 23 to to IN cord-005902-5zuij5i3 150 24 the the DT cord-005902-5zuij5i3 150 25 elbow elbow NN cord-005902-5zuij5i3 150 26 . . . cord-005902-5zuij5i3 151 1 However however RB cord-005902-5zuij5i3 151 2 , , , cord-005902-5zuij5i3 151 3 the the DT cord-005902-5zuij5i3 151 4 patient patient NN cord-005902-5zuij5i3 151 5 did do VBD cord-005902-5zuij5i3 151 6 not not RB cord-005902-5zuij5i3 151 7 recover recover VB cord-005902-5zuij5i3 151 8 very very RB cord-005902-5zuij5i3 151 9 well well RB cord-005902-5zuij5i3 151 10 afterwards afterwards RB cord-005902-5zuij5i3 151 11 in in IN cord-005902-5zuij5i3 151 12 the the DT cord-005902-5zuij5i3 151 13 intensive intensive JJ cord-005902-5zuij5i3 151 14 care care NN cord-005902-5zuij5i3 151 15 unit unit NN cord-005902-5zuij5i3 151 16 . . . cord-005902-5zuij5i3 152 1 Finally finally RB cord-005902-5zuij5i3 152 2 he -PRON- PRP cord-005902-5zuij5i3 152 3 was be VBD cord-005902-5zuij5i3 152 4 brought bring VBN cord-005902-5zuij5i3 152 5 back back RB cord-005902-5zuij5i3 152 6 to to IN cord-005902-5zuij5i3 152 7 surgery surgery NN cord-005902-5zuij5i3 152 8 -on -on : cord-005902-5zuij5i3 152 9 the the DT cord-005902-5zuij5i3 152 10 same same JJ cord-005902-5zuij5i3 152 11 day day NN cord-005902-5zuij5i3 152 12 -and -and : cord-005902-5zuij5i3 152 13 a a DT cord-005902-5zuij5i3 152 14 radical radical JJ cord-005902-5zuij5i3 152 15 debridement debridement NN cord-005902-5zuij5i3 152 16 was be VBD cord-005902-5zuij5i3 152 17 performed perform VBN cord-005902-5zuij5i3 152 18 , , , cord-005902-5zuij5i3 152 19 including include VBG cord-005902-5zuij5i3 152 20 the the DT cord-005902-5zuij5i3 152 21 amputation amputation NN cord-005902-5zuij5i3 152 22 of of IN cord-005902-5zuij5i3 152 23 the the DT cord-005902-5zuij5i3 152 24 ring ring NN cord-005902-5zuij5i3 152 25 finger finger NN cord-005902-5zuij5i3 152 26 and and CC cord-005902-5zuij5i3 152 27 excision excision NN cord-005902-5zuij5i3 152 28 of of IN cord-005902-5zuij5i3 152 29 all all DT cord-005902-5zuij5i3 152 30 obvious obvious JJ cord-005902-5zuij5i3 152 31 involved involve VBN cord-005902-5zuij5i3 152 32 fascias fascia NNS cord-005902-5zuij5i3 152 33 ( ( -LRB- cord-005902-5zuij5i3 152 34 Figure figure NN cord-005902-5zuij5i3 152 35 4 4 CD cord-005902-5zuij5i3 152 36 ) ) -RRB- cord-005902-5zuij5i3 152 37 . . . cord-005902-5zuij5i3 153 1 After after IN cord-005902-5zuij5i3 153 2 this this DT cord-005902-5zuij5i3 153 3 , , , cord-005902-5zuij5i3 153 4 four four CD cord-005902-5zuij5i3 153 5 more more JJR cord-005902-5zuij5i3 153 6 wound wound NN cord-005902-5zuij5i3 153 7 care care NN cord-005902-5zuij5i3 153 8 procedures procedure NNS cord-005902-5zuij5i3 153 9 were be VBD cord-005902-5zuij5i3 153 10 done do VBN cord-005902-5zuij5i3 153 11 in in IN cord-005902-5zuij5i3 153 12 the the DT cord-005902-5zuij5i3 153 13 operating operate VBG cord-005902-5zuij5i3 153 14 theatre theatre NN cord-005902-5zuij5i3 153 15 . . . cord-005902-5zuij5i3 154 1 Finally finally RB cord-005902-5zuij5i3 154 2 after after IN cord-005902-5zuij5i3 154 3 6 6 CD cord-005902-5zuij5i3 154 4 days day NNS cord-005902-5zuij5i3 154 5 the the DT cord-005902-5zuij5i3 154 6 wounds wound NNS cord-005902-5zuij5i3 154 7 could could MD cord-005902-5zuij5i3 154 8 be be VB cord-005902-5zuij5i3 154 9 closed close VBN cord-005902-5zuij5i3 154 10 with with IN cord-005902-5zuij5i3 154 11 a a DT cord-005902-5zuij5i3 154 12 pedicle pedicle NN cord-005902-5zuij5i3 154 13 groin groin NN cord-005902-5zuij5i3 154 14 flap flap NN cord-005902-5zuij5i3 154 15 and and CC cord-005902-5zuij5i3 154 16 skin skin NN cord-005902-5zuij5i3 154 17 graft graft NN cord-005902-5zuij5i3 154 18 . . . cord-005902-5zuij5i3 155 1 Three three CD cord-005902-5zuij5i3 155 2 more more JJR cord-005902-5zuij5i3 155 3 reconstructive reconstructive JJ cord-005902-5zuij5i3 155 4 procedures procedure NNS cord-005902-5zuij5i3 155 5 were be VBD cord-005902-5zuij5i3 155 6 followed follow VBN cord-005902-5zuij5i3 155 7 including include VBG cord-005902-5zuij5i3 155 8 flap flap NN cord-005902-5zuij5i3 155 9 division division NN cord-005902-5zuij5i3 155 10 , , , cord-005902-5zuij5i3 155 11 and and CC cord-005902-5zuij5i3 155 12 two two CD cord-005902-5zuij5i3 155 13 more more JJR cord-005902-5zuij5i3 155 14 correction correction NN cord-005902-5zuij5i3 155 15 with with IN cord-005902-5zuij5i3 155 16 a a DT cord-005902-5zuij5i3 155 17 final final JJ cord-005902-5zuij5i3 155 18 skin skin NN cord-005902-5zuij5i3 155 19 graft graft NN cord-005902-5zuij5i3 155 20 ( ( -LRB- cord-005902-5zuij5i3 155 21 Figures figure NNS cord-005902-5zuij5i3 155 22 5 5 CD cord-005902-5zuij5i3 155 23 and and CC cord-005902-5zuij5i3 155 24 6 6 CD cord-005902-5zuij5i3 155 25 ) ) -RRB- cord-005902-5zuij5i3 155 26 . . . cord-005902-5zuij5i3 156 1 During during IN cord-005902-5zuij5i3 156 2 the the DT cord-005902-5zuij5i3 156 3 treatment treatment NN cord-005902-5zuij5i3 156 4 period period NN cord-005902-5zuij5i3 156 5 at at IN cord-005902-5zuij5i3 156 6 the the DT cord-005902-5zuij5i3 156 7 intensive intensive JJ cord-005902-5zuij5i3 156 8 care care NN cord-005902-5zuij5i3 156 9 unit unit NN cord-005902-5zuij5i3 156 10 also also RB cord-005902-5zuij5i3 156 11 HBO HBO NNP cord-005902-5zuij5i3 156 12 - - HYPH cord-005902-5zuij5i3 156 13 therapy therapy NN cord-005902-5zuij5i3 156 14 was be VBD cord-005902-5zuij5i3 156 15 followed follow VBN cord-005902-5zuij5i3 156 16 daily daily RB cord-005902-5zuij5i3 156 17 starting start VBG cord-005902-5zuij5i3 156 18 at at IN cord-005902-5zuij5i3 156 19 day day NN cord-005902-5zuij5i3 156 20 1 1 CD cord-005902-5zuij5i3 156 21 for for IN cord-005902-5zuij5i3 156 22 5 5 CD cord-005902-5zuij5i3 156 23 days day NNS cord-005902-5zuij5i3 156 24 . . . cord-005902-5zuij5i3 157 1 Conclusion conclusion NN cord-005902-5zuij5i3 157 2 Necrotizing necrotize VBG cord-005902-5zuij5i3 157 3 fasciitis fasciitis NN cord-005902-5zuij5i3 157 4 ( ( -LRB- cord-005902-5zuij5i3 157 5 NF NF NNP cord-005902-5zuij5i3 157 6 ) ) -RRB- cord-005902-5zuij5i3 157 7 is be VBZ cord-005902-5zuij5i3 157 8 a a DT cord-005902-5zuij5i3 157 9 life life NN cord-005902-5zuij5i3 157 10 threatening threaten VBG cord-005902-5zuij5i3 157 11 soft soft JJ cord-005902-5zuij5i3 157 12 tissue tissue NN cord-005902-5zuij5i3 157 13 infection infection NN cord-005902-5zuij5i3 157 14 , , , cord-005902-5zuij5i3 157 15 characterized characterize VBN cord-005902-5zuij5i3 157 16 by by IN cord-005902-5zuij5i3 157 17 foudroyant foudroyant JJ cord-005902-5zuij5i3 157 18 spreading spread VBG cord-005902-5zuij5i3 157 19 necrosis necrosis NN cord-005902-5zuij5i3 157 20 of of IN cord-005902-5zuij5i3 157 21 the the DT cord-005902-5zuij5i3 157 22 involved involve VBN cord-005902-5zuij5i3 157 23 fascias fascia NNS cord-005902-5zuij5i3 157 24 . . . cord-005902-5zuij5i3 158 1 Since since IN cord-005902-5zuij5i3 158 2 a a DT cord-005902-5zuij5i3 158 3 high high JJ cord-005902-5zuij5i3 158 4 variety variety NN cord-005902-5zuij5i3 158 5 of of IN cord-005902-5zuij5i3 158 6 bacteria bacteria NNS cord-005902-5zuij5i3 158 7 can can MD cord-005902-5zuij5i3 158 8 be be VB cord-005902-5zuij5i3 158 9 isolated isolate VBN cord-005902-5zuij5i3 158 10 the the DT cord-005902-5zuij5i3 158 11 two two CD cord-005902-5zuij5i3 158 12 different different JJ cord-005902-5zuij5i3 158 13 types type NNS cord-005902-5zuij5i3 158 14 of of IN cord-005902-5zuij5i3 158 15 NF nf NN cord-005902-5zuij5i3 158 16 can can MD cord-005902-5zuij5i3 158 17 be be VB cord-005902-5zuij5i3 158 18 differentiated differentiate VBN cord-005902-5zuij5i3 158 19 : : : cord-005902-5zuij5i3 159 1 Type type NN cord-005902-5zuij5i3 159 2 1 1 CD cord-005902-5zuij5i3 159 3 characterized characterize VBN cord-005902-5zuij5i3 159 4 by by IN cord-005902-5zuij5i3 159 5 a a DT cord-005902-5zuij5i3 159 6 poly poly JJ cord-005902-5zuij5i3 159 7 - - HYPH cord-005902-5zuij5i3 159 8 bacterial bacterial JJ cord-005902-5zuij5i3 159 9 infection infection NN cord-005902-5zuij5i3 159 10 of of IN cord-005902-5zuij5i3 159 11 aerobic aerobic JJ cord-005902-5zuij5i3 159 12 and and CC cord-005902-5zuij5i3 159 13 anaerobic anaerobic JJ cord-005902-5zuij5i3 159 14 bacteria bacteria NNS cord-005902-5zuij5i3 159 15 and and CC cord-005902-5zuij5i3 159 16 Type type NN cord-005902-5zuij5i3 159 17 2 2 CD cord-005902-5zuij5i3 159 18 with with IN cord-005902-5zuij5i3 159 19 streptococci streptococcus NNS cord-005902-5zuij5i3 159 20 group group NN cord-005902-5zuij5i3 159 21 A a NN cord-005902-5zuij5i3 159 22 as as IN cord-005902-5zuij5i3 159 23 source source NN cord-005902-5zuij5i3 159 24 of of IN cord-005902-5zuij5i3 159 25 infection infection NN cord-005902-5zuij5i3 159 26 [ [ -LRB- cord-005902-5zuij5i3 159 27 39 39 CD cord-005902-5zuij5i3 159 28 ] ] -RRB- cord-005902-5zuij5i3 159 29 . . . cord-005902-5zuij5i3 160 1 The the DT cord-005902-5zuij5i3 160 2 type type NN cord-005902-5zuij5i3 160 3 2 2 CD cord-005902-5zuij5i3 160 4 infections infection NNS cord-005902-5zuij5i3 160 5 are be VBP cord-005902-5zuij5i3 160 6 less less RBR cord-005902-5zuij5i3 160 7 common common JJ cord-005902-5zuij5i3 160 8 , , , cord-005902-5zuij5i3 160 9 but but CC cord-005902-5zuij5i3 160 10 are be VBP cord-005902-5zuij5i3 160 11 more more RBR cord-005902-5zuij5i3 160 12 often often RB cord-005902-5zuij5i3 160 13 found find VBN cord-005902-5zuij5i3 160 14 in in IN cord-005902-5zuij5i3 160 15 the the DT cord-005902-5zuij5i3 160 16 case case NN cord-005902-5zuij5i3 160 17 of of IN cord-005902-5zuij5i3 160 18 the the DT cord-005902-5zuij5i3 160 19 involvement involvement NN cord-005902-5zuij5i3 160 20 of of IN cord-005902-5zuij5i3 160 21 extremities extremity NNS cord-005902-5zuij5i3 160 22 . . . cord-005902-5zuij5i3 161 1 Every every DT cord-005902-5zuij5i3 161 2 fascia fascia NN cord-005902-5zuij5i3 161 3 in in IN cord-005902-5zuij5i3 161 4 the the DT cord-005902-5zuij5i3 161 5 body body NN cord-005902-5zuij5i3 161 6 can can MD cord-005902-5zuij5i3 161 7 be be VB cord-005902-5zuij5i3 161 8 destroyed destroy VBN cord-005902-5zuij5i3 161 9 by by IN cord-005902-5zuij5i3 161 10 this this DT cord-005902-5zuij5i3 161 11 disease disease NN cord-005902-5zuij5i3 161 12 . . . cord-005902-5zuij5i3 162 1 Early early JJ cord-005902-5zuij5i3 162 2 diagnosis diagnosis NN cord-005902-5zuij5i3 162 3 is be VBZ cord-005902-5zuij5i3 162 4 critical critical JJ cord-005902-5zuij5i3 162 5 to to IN cord-005902-5zuij5i3 162 6 the the DT cord-005902-5zuij5i3 162 7 survival survival NN cord-005902-5zuij5i3 162 8 of of IN cord-005902-5zuij5i3 162 9 the the DT cord-005902-5zuij5i3 162 10 patient patient NN cord-005902-5zuij5i3 162 11 and and CC cord-005902-5zuij5i3 162 12 must must MD cord-005902-5zuij5i3 162 13 rely rely VB cord-005902-5zuij5i3 162 14 on on IN cord-005902-5zuij5i3 162 15 the the DT cord-005902-5zuij5i3 162 16 clinical clinical JJ cord-005902-5zuij5i3 162 17 picture picture NN cord-005902-5zuij5i3 162 18 . . . cord-005902-5zuij5i3 163 1 When when WRB cord-005902-5zuij5i3 163 2 there there EX cord-005902-5zuij5i3 163 3 is be VBZ cord-005902-5zuij5i3 163 4 doubt doubt NN cord-005902-5zuij5i3 163 5 , , , cord-005902-5zuij5i3 163 6 there there EX cord-005902-5zuij5i3 163 7 should should MD cord-005902-5zuij5i3 163 8 be be VB cord-005902-5zuij5i3 163 9 no no DT cord-005902-5zuij5i3 163 10 delay delay NN cord-005902-5zuij5i3 163 11 in in IN cord-005902-5zuij5i3 163 12 performing perform VBG cord-005902-5zuij5i3 163 13 surgery surgery NN cord-005902-5zuij5i3 163 14 with with IN cord-005902-5zuij5i3 163 15 radical radical JJ cord-005902-5zuij5i3 163 16 debridement debridement NN cord-005902-5zuij5i3 163 17 . . . cord-005902-5zuij5i3 164 1 The the DT cord-005902-5zuij5i3 164 2 suggested suggest VBN cord-005902-5zuij5i3 164 3 treatment treatment NN cord-005902-5zuij5i3 164 4 strategy strategy NN cord-005902-5zuij5i3 164 5 with with IN cord-005902-5zuij5i3 164 6 adequate adequate JJ cord-005902-5zuij5i3 164 7 early early JJ cord-005902-5zuij5i3 164 8 surgical surgical JJ cord-005902-5zuij5i3 164 9 and and CC cord-005902-5zuij5i3 164 10 intensive intensive JJ cord-005902-5zuij5i3 164 11 care care NN cord-005902-5zuij5i3 164 12 medicine medicine NN cord-005902-5zuij5i3 164 13 could could MD cord-005902-5zuij5i3 164 14 help help VB cord-005902-5zuij5i3 164 15 reduce reduce VB cord-005902-5zuij5i3 164 16 the the DT cord-005902-5zuij5i3 164 17 up up RP cord-005902-5zuij5i3 164 18 to to TO cord-005902-5zuij5i3 164 19 70 70 CD cord-005902-5zuij5i3 164 20 % % NN cord-005902-5zuij5i3 164 21 lethality lethality NN cord-005902-5zuij5i3 164 22 rate rate NN cord-005902-5zuij5i3 164 23 , , , cord-005902-5zuij5i3 164 24 as as IN cord-005902-5zuij5i3 164 25 stated state VBN cord-005902-5zuij5i3 164 26 in in IN cord-005902-5zuij5i3 164 27 some some DT cord-005902-5zuij5i3 164 28 publications publication NNS cord-005902-5zuij5i3 164 29 , , , cord-005902-5zuij5i3 164 30 to to IN cord-005902-5zuij5i3 164 31 less less JJR cord-005902-5zuij5i3 164 32 than than IN cord-005902-5zuij5i3 164 33 10 10 CD cord-005902-5zuij5i3 164 34 % % NN cord-005902-5zuij5i3 164 35 [ [ -LRB- cord-005902-5zuij5i3 164 36 40 40 CD cord-005902-5zuij5i3 164 37 ] ] -RRB- cord-005902-5zuij5i3 165 1 [ [ -LRB- cord-005902-5zuij5i3 165 2 41 41 CD cord-005902-5zuij5i3 165 3 ] ] -RRB- cord-005902-5zuij5i3 165 4 [ [ -LRB- cord-005902-5zuij5i3 165 5 42 42 CD cord-005902-5zuij5i3 165 6 ] ] -RRB- cord-005902-5zuij5i3 165 7 . . . cord-005902-5zuij5i3 166 1 Infections infection NNS cord-005902-5zuij5i3 166 2 of of IN cord-005902-5zuij5i3 166 3 the the DT cord-005902-5zuij5i3 166 4 extremities extremity NNS cord-005902-5zuij5i3 166 5 are be VBP cord-005902-5zuij5i3 166 6 less less RBR cord-005902-5zuij5i3 166 7 likely likely RB cord-005902-5zuij5i3 166 8 lethal lethal JJ cord-005902-5zuij5i3 166 9 , , , cord-005902-5zuij5i3 166 10 whereas whereas IN cord-005902-5zuij5i3 166 11 an an DT cord-005902-5zuij5i3 166 12 intra intra JJ cord-005902-5zuij5i3 166 13 - - JJ cord-005902-5zuij5i3 166 14 abdominal abdominal JJ cord-005902-5zuij5i3 166 15 occurrence occurrence NN cord-005902-5zuij5i3 166 16 leads lead VBZ cord-005902-5zuij5i3 166 17 mostly mostly RB cord-005902-5zuij5i3 166 18 to to IN cord-005902-5zuij5i3 166 19 the the DT cord-005902-5zuij5i3 166 20 death death NN cord-005902-5zuij5i3 166 21 of of IN cord-005902-5zuij5i3 166 22 the the DT cord-005902-5zuij5i3 166 23 patient patient NN cord-005902-5zuij5i3 166 24 . . . cord-005902-5zuij5i3 167 1 Higher high JJR cord-005902-5zuij5i3 167 2 age age NN cord-005902-5zuij5i3 167 3 , , , cord-005902-5zuij5i3 167 4 diabetes diabetes NN cord-005902-5zuij5i3 167 5 , , , cord-005902-5zuij5i3 167 6 arterial arterial JJ cord-005902-5zuij5i3 167 7 occlusive occlusive JJ cord-005902-5zuij5i3 167 8 disease disease NN cord-005902-5zuij5i3 167 9 , , , cord-005902-5zuij5i3 167 10 immunosuppressant immunosuppressant JJ cord-005902-5zuij5i3 167 11 status status NN cord-005902-5zuij5i3 167 12 and and CC cord-005902-5zuij5i3 167 13 the the DT cord-005902-5zuij5i3 167 14 onset onset NN cord-005902-5zuij5i3 167 15 of of IN cord-005902-5zuij5i3 167 16 NF nf NN cord-005902-5zuij5i3 167 17 due due IN cord-005902-5zuij5i3 167 18 to to IN cord-005902-5zuij5i3 167 19 iatrogenic iatrogenic JJ cord-005902-5zuij5i3 167 20 infections infection NNS cord-005902-5zuij5i3 167 21 is be VBZ cord-005902-5zuij5i3 167 22 linked link VBN cord-005902-5zuij5i3 167 23 to to IN cord-005902-5zuij5i3 167 24 a a DT cord-005902-5zuij5i3 167 25 much much RB cord-005902-5zuij5i3 167 26 worse bad JJR cord-005902-5zuij5i3 167 27 prognosis prognosis NN cord-005902-5zuij5i3 167 28 . . . cord-005902-5zuij5i3 168 1 NF NF NNP cord-005902-5zuij5i3 168 2 is be VBZ cord-005902-5zuij5i3 168 3 an an DT cord-005902-5zuij5i3 168 4 infection infection NN cord-005902-5zuij5i3 168 5 still still RB cord-005902-5zuij5i3 168 6 observed observe VBD cord-005902-5zuij5i3 168 7 very very RB cord-005902-5zuij5i3 168 8 seldom seldom RB cord-005902-5zuij5i3 168 9 ; ; : cord-005902-5zuij5i3 168 10 however however RB cord-005902-5zuij5i3 168 11 , , , cord-005902-5zuij5i3 168 12 some some DT cord-005902-5zuij5i3 168 13 data datum NNS cord-005902-5zuij5i3 168 14 indicate indicate VBP cord-005902-5zuij5i3 168 15 an an DT cord-005902-5zuij5i3 168 16 increase increase NN cord-005902-5zuij5i3 168 17 of of IN cord-005902-5zuij5i3 168 18 this this DT cord-005902-5zuij5i3 168 19 type type NN cord-005902-5zuij5i3 168 20 of of IN cord-005902-5zuij5i3 168 21 infection infection NN cord-005902-5zuij5i3 168 22 in in IN cord-005902-5zuij5i3 168 23 the the DT cord-005902-5zuij5i3 168 24 last last JJ cord-005902-5zuij5i3 168 25 decade decade NN cord-005902-5zuij5i3 168 26 , , , cord-005902-5zuij5i3 168 27 therefore therefore RB cord-005902-5zuij5i3 168 28 clinicians clinician NNS cord-005902-5zuij5i3 168 29 should should MD cord-005902-5zuij5i3 168 30 be be VB cord-005902-5zuij5i3 168 31 aware aware JJ cord-005902-5zuij5i3 168 32 and and CC cord-005902-5zuij5i3 168 33 alert alert JJ cord-005902-5zuij5i3 168 34 in in IN cord-005902-5zuij5i3 168 35 cases case NNS cord-005902-5zuij5i3 168 36 of of IN cord-005902-5zuij5i3 168 37 a a DT cord-005902-5zuij5i3 168 38 significant significant JJ cord-005902-5zuij5i3 168 39 soft soft JJ cord-005902-5zuij5i3 168 40 tissue tissue NN cord-005902-5zuij5i3 168 41 infection infection NN cord-005902-5zuij5i3 168 42 to to TO cord-005902-5zuij5i3 168 43 rule rule VB cord-005902-5zuij5i3 168 44 out out RP cord-005902-5zuij5i3 168 45 NF nf NN cord-005902-5zuij5i3 168 46 . . . cord-005902-5zuij5i3 169 1 Hippokrates Hippokrates NNPS cord-005902-5zuij5i3 169 2 : : : cord-005902-5zuij5i3 170 1 Zweites Zweites NNP cord-005902-5zuij5i3 170 2 Buch Buch NNP cord-005902-5zuij5i3 170 3 der der NN cord-005902-5zuij5i3 170 4 Volkskrankheiten Volkskrankheiten NNP cord-005902-5zuij5i3 170 5 Necrotising Necrotising NNP cord-005902-5zuij5i3 170 6 fasciitis fasciitis NN cord-005902-5zuij5i3 170 7 , , , cord-005902-5zuij5i3 170 8 hospital hospital NN cord-005902-5zuij5i3 170 9 gangrene gangrene NN cord-005902-5zuij5i3 170 10 , , , cord-005902-5zuij5i3 170 11 and and CC cord-005902-5zuij5i3 170 12 phagedena phagedena NNP cord-005902-5zuij5i3 170 13 Investigations Investigations NNPS cord-005902-5zuij5i3 170 14 upon upon IN cord-005902-5zuij5i3 170 15 the the DT cord-005902-5zuij5i3 170 16 nature nature NN cord-005902-5zuij5i3 170 17 , , , cord-005902-5zuij5i3 170 18 causes cause NNS cord-005902-5zuij5i3 170 19 and and CC cord-005902-5zuij5i3 170 20 treatment treatment NN cord-005902-5zuij5i3 170 21 of of IN cord-005902-5zuij5i3 170 22 hospital hospital NN cord-005902-5zuij5i3 170 23 gangrene gangrene NN cord-005902-5zuij5i3 170 24 as as IN cord-005902-5zuij5i3 170 25 it -PRON- PRP cord-005902-5zuij5i3 170 26 prevailed prevail VBD cord-005902-5zuij5i3 170 27 in in IN cord-005902-5zuij5i3 170 28 the the DT cord-005902-5zuij5i3 170 29 confederate confederate JJ cord-005902-5zuij5i3 170 30 armies army NNS cord-005902-5zuij5i3 170 31 1861 1861 CD cord-005902-5zuij5i3 170 32 - - SYM cord-005902-5zuij5i3 170 33 1865 1865 CD cord-005902-5zuij5i3 170 34 Zur Zur NNP cord-005902-5zuij5i3 170 35 Kenntnis Kenntnis NNP cord-005902-5zuij5i3 170 36 und und IN cord-005902-5zuij5i3 170 37 Behandlung Behandlung NNP cord-005902-5zuij5i3 170 38 des des NNP cord-005902-5zuij5i3 170 39 nekrotisierenden nekrotisierenden NNP cord-005902-5zuij5i3 170 40 Erysipels Erysipels NNP cord-005902-5zuij5i3 170 41 Hemolytic Hemolytic NNP cord-005902-5zuij5i3 171 1 streptococcal streptococcal JJ cord-005902-5zuij5i3 171 2 gangrene gangrene NN cord-005902-5zuij5i3 171 3 Gangrene gangrene NN cord-005902-5zuij5i3 172 1 foudroyante foudroyante JJ cord-005902-5zuij5i3 173 1 de de NNP cord-005902-5zuij5i3 173 2 la la NNP cord-005902-5zuij5i3 174 1 verge verge JJ cord-005902-5zuij5i3 174 2 Necrotizing necrotize VBG cord-005902-5zuij5i3 174 3 fasciitis fasciitis NN cord-005902-5zuij5i3 174 4 Necrotizing necrotize VBG cord-005902-5zuij5i3 174 5 fasciitis fasciitis NN cord-005902-5zuij5i3 174 6 Necrotizing necrotize VBG cord-005902-5zuij5i3 174 7 cellulitis cellulitis NN cord-005902-5zuij5i3 174 8 complicating complicate VBG cord-005902-5zuij5i3 174 9 varicella varicella NN cord-005902-5zuij5i3 174 10 in in IN cord-005902-5zuij5i3 174 11 two two CD cord-005902-5zuij5i3 174 12 children child NNS cord-005902-5zuij5i3 174 13 given give VBN cord-005902-5zuij5i3 174 14 nonsteroidal nonsteroidal JJ cord-005902-5zuij5i3 174 15 antiinflammatory antiinflammatory JJ cord-005902-5zuij5i3 174 16 drugs drug NNS cord-005902-5zuij5i3 174 17 Chirurgisches Chirurgisches NNP cord-005902-5zuij5i3 174 18 Konzept Konzept NNP cord-005902-5zuij5i3 174 19 und und IN cord-005902-5zuij5i3 174 20 Ergebnisse Ergebnisse NNP cord-005902-5zuij5i3 174 21 bei bei NNP cord-005902-5zuij5i3 174 22 nekrotisierender nekrotisierender NN cord-005902-5zuij5i3 174 23 Fasziitis Fasziitis NNP cord-005902-5zuij5i3 174 24 Streptococcal Streptococcal NNP cord-005902-5zuij5i3 174 25 infections infection NNS cord-005902-5zuij5i3 174 26 of of IN cord-005902-5zuij5i3 174 27 the the DT cord-005902-5zuij5i3 174 28 skin skin NN cord-005902-5zuij5i3 174 29 and and CC cord-005902-5zuij5i3 174 30 the the DT cord-005902-5zuij5i3 174 31 soft soft JJ cord-005902-5zuij5i3 174 32 tissues tissue NNS cord-005902-5zuij5i3 175 1 A a DT cord-005902-5zuij5i3 175 2 multicenter multicenter JJ cord-005902-5zuij5i3 175 3 review review NN cord-005902-5zuij5i3 175 4 of of IN cord-005902-5zuij5i3 175 5 the the DT cord-005902-5zuij5i3 175 6 treatment treatment NN cord-005902-5zuij5i3 175 7 of of IN cord-005902-5zuij5i3 175 8 major major JJ cord-005902-5zuij5i3 175 9 truncal truncal JJ cord-005902-5zuij5i3 175 10 necrotizing necrotize VBG cord-005902-5zuij5i3 175 11 infections infection NNS cord-005902-5zuij5i3 175 12 with with IN cord-005902-5zuij5i3 175 13 and and CC cord-005902-5zuij5i3 175 14 without without IN cord-005902-5zuij5i3 175 15 hyperbaric hyperbaric NN cord-005902-5zuij5i3 175 16 oxygen oxygen NN cord-005902-5zuij5i3 175 17 therapy therapy NN cord-005902-5zuij5i3 175 18 Infections infection NNS cord-005902-5zuij5i3 175 19 by by IN cord-005902-5zuij5i3 175 20 Streptococcus streptococcus NN cord-005902-5zuij5i3 175 21 pyogenes pyogene NNS cord-005902-5zuij5i3 175 22 : : : cord-005902-5zuij5i3 175 23 new new JJ cord-005902-5zuij5i3 175 24 aspects aspect NNS cord-005902-5zuij5i3 175 25 of of IN cord-005902-5zuij5i3 175 26 diagnosis diagnosis NN cord-005902-5zuij5i3 175 27 , , , cord-005902-5zuij5i3 175 28 epidemiology epidemiology NN cord-005902-5zuij5i3 175 29 , , , cord-005902-5zuij5i3 175 30 clinical clinical JJ cord-005902-5zuij5i3 175 31 practice practice NN cord-005902-5zuij5i3 175 32 , , , cord-005902-5zuij5i3 175 33 and and CC cord-005902-5zuij5i3 175 34 therapy therapy NN cord-005902-5zuij5i3 175 35 Changing change VBG cord-005902-5zuij5i3 175 36 epidemiology epidemiology NN cord-005902-5zuij5i3 175 37 of of IN cord-005902-5zuij5i3 175 38 group group NN cord-005902-5zuij5i3 175 39 A a DT cord-005902-5zuij5i3 175 40 streptococcal streptococcal JJ cord-005902-5zuij5i3 175 41 infections infection NNS cord-005902-5zuij5i3 175 42 in in IN cord-005902-5zuij5i3 175 43 the the DT cord-005902-5zuij5i3 175 44 USA USA NNP cord-005902-5zuij5i3 175 45 Outbreak Outbreak NNP cord-005902-5zuij5i3 175 46 of of IN cord-005902-5zuij5i3 175 47 group group NN cord-005902-5zuij5i3 175 48 A a DT cord-005902-5zuij5i3 175 49 bacteremia bacteremia NN cord-005902-5zuij5i3 175 50 in in IN cord-005902-5zuij5i3 175 51 Sweden Sweden NNP cord-005902-5zuij5i3 175 52 : : : cord-005902-5zuij5i3 175 53 an an DT cord-005902-5zuij5i3 175 54 epidemiologic epidemiologic JJ cord-005902-5zuij5i3 175 55 and and CC cord-005902-5zuij5i3 175 56 clinical clinical JJ cord-005902-5zuij5i3 175 57 study study NN cord-005902-5zuij5i3 175 58 Outbreak outbreak NN cord-005902-5zuij5i3 175 59 of of IN cord-005902-5zuij5i3 175 60 group group NN cord-005902-5zuij5i3 175 61 A a DT cord-005902-5zuij5i3 175 62 streptococcus streptococcus NN cord-005902-5zuij5i3 175 63 septicemia septicemia NN cord-005902-5zuij5i3 175 64 in in IN cord-005902-5zuij5i3 175 65 children child NNS cord-005902-5zuij5i3 176 1 Molecular molecular JJ cord-005902-5zuij5i3 176 2 characterization characterization NN cord-005902-5zuij5i3 176 3 of of IN cord-005902-5zuij5i3 176 4 clinical clinical JJ cord-005902-5zuij5i3 176 5 isolates isolate NNS cord-005902-5zuij5i3 176 6 of of IN cord-005902-5zuij5i3 176 7 M M NNP cord-005902-5zuij5i3 176 8 non non JJ cord-005902-5zuij5i3 176 9 - - JJ cord-005902-5zuij5i3 176 10 typable typable JJ cord-005902-5zuij5i3 176 11 group group NN cord-005902-5zuij5i3 177 1 A a DT cord-005902-5zuij5i3 177 2 streptococci streptococcus NNS cord-005902-5zuij5i3 177 3 from from IN cord-005902-5zuij5i3 177 4 invasive invasive JJ cord-005902-5zuij5i3 177 5 disease disease NN cord-005902-5zuij5i3 177 6 cases case NNS cord-005902-5zuij5i3 177 7 . . . cord-005902-5zuij5i3 178 1 1 1 LS cord-005902-5zuij5i3 179 1 Neutrophil Neutrophil NNP cord-005902-5zuij5i3 179 2 extracellular extracellular JJ cord-005902-5zuij5i3 179 3 traps trap NNS cord-005902-5zuij5i3 179 4 : : : cord-005902-5zuij5i3 179 5 casting cast VBG cord-005902-5zuij5i3 179 6 the the DT cord-005902-5zuij5i3 179 7 NET net NN cord-005902-5zuij5i3 179 8 over over IN cord-005902-5zuij5i3 179 9 pathogenesis pathogenesis NN cord-005902-5zuij5i3 179 10 Invasive invasive JJ cord-005902-5zuij5i3 179 11 group group NN cord-005902-5zuij5i3 179 12 A a DT cord-005902-5zuij5i3 179 13 streptococcus streptococcus NN cord-005902-5zuij5i3 179 14 infections infection NNS cord-005902-5zuij5i3 179 15 Progressive progressive JJ cord-005902-5zuij5i3 179 16 necrotizing necrotize VBG cord-005902-5zuij5i3 179 17 surgical surgical JJ cord-005902-5zuij5i3 179 18 infections infection NNS cord-005902-5zuij5i3 179 19 : : : cord-005902-5zuij5i3 179 20 a a DT cord-005902-5zuij5i3 179 21 unified unified JJ cord-005902-5zuij5i3 179 22 approach approach NN cord-005902-5zuij5i3 180 1 The the DT cord-005902-5zuij5i3 180 2 microbiology microbiology NN cord-005902-5zuij5i3 180 3 of of IN cord-005902-5zuij5i3 180 4 necrotizing necrotize VBG cord-005902-5zuij5i3 180 5 soft soft JJ cord-005902-5zuij5i3 180 6 - - HYPH cord-005902-5zuij5i3 180 7 tissue tissue NN cord-005902-5zuij5i3 180 8 infections infection NNS cord-005902-5zuij5i3 180 9 Predictors predictor NNS cord-005902-5zuij5i3 180 10 of of IN cord-005902-5zuij5i3 180 11 mortality mortality NN cord-005902-5zuij5i3 180 12 and and CC cord-005902-5zuij5i3 180 13 limb limb NN cord-005902-5zuij5i3 180 14 loss loss NN cord-005902-5zuij5i3 180 15 in in IN cord-005902-5zuij5i3 180 16 necrotizing necrotize VBG cord-005902-5zuij5i3 180 17 soft soft JJ cord-005902-5zuij5i3 180 18 tissue tissue NN cord-005902-5zuij5i3 180 19 infections infection NNS cord-005902-5zuij5i3 180 20 Clinical clinical JJ cord-005902-5zuij5i3 180 21 picture picture NN cord-005902-5zuij5i3 180 22 of of IN cord-005902-5zuij5i3 180 23 the the DT cord-005902-5zuij5i3 180 24 forearm forearm NN cord-005902-5zuij5i3 180 25 after after IN cord-005902-5zuij5i3 180 26 the the DT cord-005902-5zuij5i3 180 27 reconstruction reconstruction NN cord-005902-5zuij5i3 180 28 was be VBD cord-005902-5zuij5i3 180 29 performed perform VBN cord-005902-5zuij5i3 180 30 . . . cord-005902-5zuij5i3 181 1 Further further JJ cord-005902-5zuij5i3 181 2 debulging debulge VBG cord-005902-5zuij5i3 181 3 had have VBD cord-005902-5zuij5i3 181 4 not not RB cord-005902-5zuij5i3 181 5 been be VBN cord-005902-5zuij5i3 181 6 done do VBN cord-005902-5zuij5i3 181 7 yet yet RB cord-005902-5zuij5i3 181 8 Necrotizing necrotize VBG cord-005902-5zuij5i3 181 9 Fasciitis fasciitis NN cord-005902-5zuij5i3 181 10 of of IN cord-005902-5zuij5i3 181 11 the the DT cord-005902-5zuij5i3 181 12 Upper upper JJ cord-005902-5zuij5i3 181 13 and and CC cord-005902-5zuij5i3 181 14 Lower Lower NNP cord-005902-5zuij5i3 181 15 Extremities Extremities NNPS cord-005902-5zuij5i3 181 16 Eur Eur NNP cord-005902-5zuij5i3 181 17 Surviving survive VBG cord-005902-5zuij5i3 181 18 sepsis sepsis NN cord-005902-5zuij5i3 181 19 campaign campaign NN cord-005902-5zuij5i3 181 20 : : : cord-005902-5zuij5i3 182 1 International international JJ cord-005902-5zuij5i3 182 2 guidelines guideline NNS cord-005902-5zuij5i3 182 3 for for IN cord-005902-5zuij5i3 182 4 management management NN cord-005902-5zuij5i3 182 5 of of IN cord-005902-5zuij5i3 182 6 severe severe JJ cord-005902-5zuij5i3 182 7 sepsis sepsis NN cord-005902-5zuij5i3 182 8 and and CC cord-005902-5zuij5i3 182 9 septic septic JJ cord-005902-5zuij5i3 182 10 shock shock NN cord-005902-5zuij5i3 182 11 Prophylactic prophylactic JJ cord-005902-5zuij5i3 182 12 hemofiltration hemofiltration NN cord-005902-5zuij5i3 182 13 in in IN cord-005902-5zuij5i3 182 14 severely severely RB cord-005902-5zuij5i3 182 15 traumatized traumatize VBN cord-005902-5zuij5i3 182 16 patients patient NNS cord-005902-5zuij5i3 182 17 : : : cord-005902-5zuij5i3 183 1 I. i. LS cord-005902-5zuij5i3 183 2 Effects effect NNS cord-005902-5zuij5i3 183 3 on on IN cord-005902-5zuij5i3 183 4 posttraumatic posttraumatic JJ cord-005902-5zuij5i3 183 5 organ organ NN cord-005902-5zuij5i3 183 6 dysfunction dysfunction NN cord-005902-5zuij5i3 183 7 syndrome syndrome NN cord-005902-5zuij5i3 184 1 Necrotising Necrotising NNP cord-005902-5zuij5i3 184 2 fasciitis fasciitis NN cord-005902-5zuij5i3 184 3 : : : cord-005902-5zuij5i3 184 4 a a DT cord-005902-5zuij5i3 184 5 single single JJ cord-005902-5zuij5i3 184 6 centre centre NN cord-005902-5zuij5i3 184 7 's 's POS cord-005902-5zuij5i3 184 8 experience experience NN cord-005902-5zuij5i3 184 9 Hyperbaric Hyperbaric NNP cord-005902-5zuij5i3 184 10 Oxygen Oxygen NNP cord-005902-5zuij5i3 184 11 Therapy Therapy NNP cord-005902-5zuij5i3 184 12 : : : cord-005902-5zuij5i3 184 13 1999 1999 CD cord-005902-5zuij5i3 184 14 Committee Committee NNP cord-005902-5zuij5i3 184 15 Report Report NNP cord-005902-5zuij5i3 184 16 . . . cord-005902-5zuij5i3 185 1 Kensington Kensington NNP cord-005902-5zuij5i3 185 2 : : : cord-005902-5zuij5i3 186 1 Undersea undersea JJ cord-005902-5zuij5i3 186 2 and and CC cord-005902-5zuij5i3 186 3 Hyperbaric Hyperbaric NNP cord-005902-5zuij5i3 186 4 Medical Medical NNP cord-005902-5zuij5i3 186 5 Society Society NNP cord-005902-5zuij5i3 186 6 Life Life NNP cord-005902-5zuij5i3 186 7 without without IN cord-005902-5zuij5i3 186 8 blood blood NN cord-005902-5zuij5i3 186 9 . . . cord-005902-5zuij5i3 187 1 A a DT cord-005902-5zuij5i3 187 2 study study NN cord-005902-5zuij5i3 187 3 of of IN cord-005902-5zuij5i3 187 4 the the DT cord-005902-5zuij5i3 187 5 influence influence NN cord-005902-5zuij5i3 187 6 of of IN cord-005902-5zuij5i3 187 7 high high JJ cord-005902-5zuij5i3 187 8 atmospheric atmospheric JJ cord-005902-5zuij5i3 187 9 pressure pressure NN cord-005902-5zuij5i3 187 10 and and CC cord-005902-5zuij5i3 187 11 hypothermia hypothermia NN cord-005902-5zuij5i3 187 12 on on IN cord-005902-5zuij5i3 187 13 dilution dilution NN cord-005902-5zuij5i3 187 14 of of IN cord-005902-5zuij5i3 187 15 the the DT cord-005902-5zuij5i3 187 16 blood blood NN cord-005902-5zuij5i3 187 17 Reduction reduction NN cord-005902-5zuij5i3 187 18 of of IN cord-005902-5zuij5i3 187 19 postischemic postischemic JJ cord-005902-5zuij5i3 187 20 edema edema NN cord-005902-5zuij5i3 187 21 with with IN cord-005902-5zuij5i3 187 22 hyperbaric hyperbaric NN cord-005902-5zuij5i3 187 23 oxygen oxygen NN cord-005902-5zuij5i3 187 24 Hyperbaric hyperbaric NN cord-005902-5zuij5i3 187 25 oxygen oxygen NN cord-005902-5zuij5i3 187 26 reduces reduce VBZ cord-005902-5zuij5i3 187 27 edema edema NN cord-005902-5zuij5i3 187 28 , , , cord-005902-5zuij5i3 187 29 necrosis necrosis NN cord-005902-5zuij5i3 187 30 of of IN cord-005902-5zuij5i3 187 31 skeletal skeletal JJ cord-005902-5zuij5i3 187 32 muscle muscle NN cord-005902-5zuij5i3 187 33 in in IN cord-005902-5zuij5i3 187 34 compartment compartment NN cord-005902-5zuij5i3 187 35 syndromes syndrome NNS cord-005902-5zuij5i3 187 36 associated associate VBN cord-005902-5zuij5i3 187 37 with with IN cord-005902-5zuij5i3 187 38 hemorrhagic hemorrhagic JJ cord-005902-5zuij5i3 187 39 hypotension hypotension NN cord-005902-5zuij5i3 187 40 Studies study NNS cord-005902-5zuij5i3 187 41 on on IN cord-005902-5zuij5i3 187 42 inflammation inflammation NN cord-005902-5zuij5i3 187 43 and and CC cord-005902-5zuij5i3 187 44 wound wound VB cord-005902-5zuij5i3 187 45 healing healing NN cord-005902-5zuij5i3 187 46 : : : cord-005902-5zuij5i3 187 47 angiogenesis angiogenesis NN cord-005902-5zuij5i3 187 48 and and CC cord-005902-5zuij5i3 187 49 collagen collagen NN cord-005902-5zuij5i3 187 50 synthesis synthesis NN cord-005902-5zuij5i3 187 51 stimulated stimulate VBN cord-005902-5zuij5i3 187 52 in in IN cord-005902-5zuij5i3 187 53 vivo vivo NN cord-005902-5zuij5i3 187 54 by by IN cord-005902-5zuij5i3 187 55 resident resident NN cord-005902-5zuij5i3 187 56 and and CC cord-005902-5zuij5i3 187 57 activated activate VBD cord-005902-5zuij5i3 187 58 wound wound NN cord-005902-5zuij5i3 187 59 macrophages macrophage NNS cord-005902-5zuij5i3 187 60 Role role NN cord-005902-5zuij5i3 187 61 of of IN cord-005902-5zuij5i3 187 62 oxygen oxygen NN cord-005902-5zuij5i3 187 63 in in IN cord-005902-5zuij5i3 187 64 repair repair NN cord-005902-5zuij5i3 187 65 processes process NNS cord-005902-5zuij5i3 187 66 Hyperbaric hyperbaric NN cord-005902-5zuij5i3 187 67 oxygen oxygen NN cord-005902-5zuij5i3 187 68 therapy therapy NN cord-005902-5zuij5i3 187 69 in in IN cord-005902-5zuij5i3 187 70 the the DT cord-005902-5zuij5i3 187 71 management management NN cord-005902-5zuij5i3 187 72 of of IN cord-005902-5zuij5i3 187 73 crush crush NN cord-005902-5zuij5i3 187 74 injuries injury NNS cord-005902-5zuij5i3 187 75 : : : cord-005902-5zuij5i3 187 76 a a DT cord-005902-5zuij5i3 187 77 randomized randomized JJ cord-005902-5zuij5i3 187 78 double double JJ cord-005902-5zuij5i3 187 79 - - HYPH cord-005902-5zuij5i3 187 80 blind blind JJ cord-005902-5zuij5i3 187 81 placebo placebo NN cord-005902-5zuij5i3 187 82 - - HYPH cord-005902-5zuij5i3 187 83 controlled control VBN cord-005902-5zuij5i3 187 84 clinical clinical JJ cord-005902-5zuij5i3 187 85 trial trial NN cord-005902-5zuij5i3 187 86 Hyperbaric hyperbaric NN cord-005902-5zuij5i3 187 87 oxygen oxygen NN cord-005902-5zuij5i3 187 88 therapy therapy NN cord-005902-5zuij5i3 187 89 for for IN cord-005902-5zuij5i3 187 90 necrotizing necrotize VBG cord-005902-5zuij5i3 187 91 fasciitis fasciitis NN cord-005902-5zuij5i3 187 92 reduces reduce VBZ cord-005902-5zuij5i3 187 93 mortality mortality NN cord-005902-5zuij5i3 187 94 and and CC cord-005902-5zuij5i3 187 95 the the DT cord-005902-5zuij5i3 187 96 need need NN cord-005902-5zuij5i3 187 97 for for IN cord-005902-5zuij5i3 187 98 debridements debridement NNS cord-005902-5zuij5i3 187 99 Necrotizing necrotize VBG cord-005902-5zuij5i3 187 100 fasciitis fasciitis NN cord-005902-5zuij5i3 187 101 : : : cord-005902-5zuij5i3 187 102 an an DT cord-005902-5zuij5i3 187 103 indication indication NN cord-005902-5zuij5i3 187 104 for for IN cord-005902-5zuij5i3 187 105 hyperbaric hyperbaric NN cord-005902-5zuij5i3 187 106 oxygenation oxygenation NN cord-005902-5zuij5i3 187 107 therapy therapy NN cord-005902-5zuij5i3 187 108 ? ? . cord-005902-5zuij5i3 188 1 Regelsberger Regelsberger NNP cord-005902-5zuij5i3 188 2 's 's POS cord-005902-5zuij5i3 188 3 intravenous intravenous JJ cord-005902-5zuij5i3 188 4 oxygen oxygen NN cord-005902-5zuij5i3 188 5 therapy therapy NN cord-005902-5zuij5i3 188 6 -an -an . cord-005902-5zuij5i3 189 1 interpretation interpretation NN cord-005902-5zuij5i3 189 2 of of IN cord-005902-5zuij5i3 189 3 results result NNS cord-005902-5zuij5i3 189 4 in in IN cord-005902-5zuij5i3 189 5 practice practice NN cord-005902-5zuij5i3 189 6 from from IN cord-005902-5zuij5i3 189 7 a a DT cord-005902-5zuij5i3 189 8 biochemical biochemical JJ cord-005902-5zuij5i3 189 9 and and CC cord-005902-5zuij5i3 189 10 physiological physiological JJ cord-005902-5zuij5i3 189 11 point point NN cord-005902-5zuij5i3 189 12 of of IN cord-005902-5zuij5i3 189 13 view view NN cord-005902-5zuij5i3 189 14 Literature literature NN cord-005902-5zuij5i3 189 15 on on IN cord-005902-5zuij5i3 189 16 the the DT cord-005902-5zuij5i3 189 17 subject subject NN cord-005902-5zuij5i3 189 18 of of IN cord-005902-5zuij5i3 189 19 vacuum vacuum NN cord-005902-5zuij5i3 189 20 therapy therapy NN cord-005902-5zuij5i3 189 21 review review NN cord-005902-5zuij5i3 189 22 and and CC cord-005902-5zuij5i3 189 23 update update VB cord-005902-5zuij5i3 189 24 Reconstruction reconstruction NN cord-005902-5zuij5i3 189 25 of of IN cord-005902-5zuij5i3 189 26 lower low JJR cord-005902-5zuij5i3 189 27 extremity extremity NN cord-005902-5zuij5i3 189 28 fractures fracture NNS cord-005902-5zuij5i3 189 29 with with IN cord-005902-5zuij5i3 189 30 soft soft JJ cord-005902-5zuij5i3 189 31 tissue tissue NN cord-005902-5zuij5i3 189 32 defects defect NNS cord-005902-5zuij5i3 189 33 Bacteriology Bacteriology NNP cord-005902-5zuij5i3 189 34 of of IN cord-005902-5zuij5i3 189 35 necrotizing necrotize VBG cord-005902-5zuij5i3 189 36 fasciitis fasciitis NN cord-005902-5zuij5i3 189 37 Improved improve VBN cord-005902-5zuij5i3 189 38 results result NNS cord-005902-5zuij5i3 189 39 from from IN cord-005902-5zuij5i3 189 40 a a DT cord-005902-5zuij5i3 189 41 standardized standardized JJ cord-005902-5zuij5i3 189 42 approach approach NN cord-005902-5zuij5i3 189 43 in in IN cord-005902-5zuij5i3 189 44 treating treat VBG cord-005902-5zuij5i3 189 45 patients patient NNS cord-005902-5zuij5i3 189 46 with with IN cord-005902-5zuij5i3 189 47 necrotizing necrotize VBG cord-005902-5zuij5i3 189 48 fasciitis fasciitis NN cord-005902-5zuij5i3 189 49 Necrotising Necrotising NNP cord-005902-5zuij5i3 189 50 fasciitis fasciitis NN cord-005902-5zuij5i3 189 51 due due JJ cord-005902-5zuij5i3 189 52 to to IN cord-005902-5zuij5i3 189 53 group group NN cord-005902-5zuij5i3 189 54 a a DT cord-005902-5zuij5i3 189 55 streptococci streptococcus NNS cord-005902-5zuij5i3 189 56 in in IN cord-005902-5zuij5i3 189 57 western western JJ cord-005902-5zuij5i3 189 58 Norway Norway NNP cord-005902-5zuij5i3 189 59 : : : cord-005902-5zuij5i3 189 60 incidence incidence NN cord-005902-5zuij5i3 189 61 and and CC cord-005902-5zuij5i3 189 62 clinical clinical JJ cord-005902-5zuij5i3 189 63 features feature NNS cord-005902-5zuij5i3 190 1 Necrotizing necrotize VBG cord-005902-5zuij5i3 190 2 fasciitis fasciitis NN cord-005902-5zuij5i3 190 3 -a -a HYPH cord-005902-5zuij5i3 190 4 preventable preventable JJ cord-005902-5zuij5i3 190 5 disaster disaster NN