id sid tid token lemma pos cord-003926-ycdaw2vh 1 1 key key NN cord-003926-ycdaw2vh 1 2 : : : cord-003926-ycdaw2vh 2 1 cord-003926-ycdaw2vh cord-003926-ycdaw2vh NNP cord-003926-ycdaw2vh 3 1 authors author NNS cord-003926-ycdaw2vh 3 2 : : : cord-003926-ycdaw2vh 3 3 Maslow Maslow NNP cord-003926-ycdaw2vh 3 4 , , , cord-003926-ycdaw2vh 3 5 Joel Joel NNP cord-003926-ycdaw2vh 3 6 N. N. NNP cord-003926-ycdaw2vh 3 7 title title NN cord-003926-ycdaw2vh 3 8 : : : cord-003926-ycdaw2vh 3 9 Zika Zika NNP cord-003926-ycdaw2vh 3 10 Vaccine Vaccine NNP cord-003926-ycdaw2vh 3 11 Development Development NNP cord-003926-ycdaw2vh 3 12 — — : cord-003926-ycdaw2vh 3 13 Current Current NNP cord-003926-ycdaw2vh 3 14 Progress Progress NNP cord-003926-ycdaw2vh 3 15 and and CC cord-003926-ycdaw2vh 3 16 Challenges challenge NNS cord-003926-ycdaw2vh 3 17 for for IN cord-003926-ycdaw2vh 3 18 the the DT cord-003926-ycdaw2vh 3 19 Future future JJ cord-003926-ycdaw2vh 3 20 date date NN cord-003926-ycdaw2vh 3 21 : : : cord-003926-ycdaw2vh 3 22 2019 2019 CD cord-003926-ycdaw2vh 3 23 - - HYPH cord-003926-ycdaw2vh 3 24 07 07 CD cord-003926-ycdaw2vh 3 25 - - SYM cord-003926-ycdaw2vh 3 26 14 14 CD cord-003926-ycdaw2vh 3 27 journal journal NN cord-003926-ycdaw2vh 3 28 : : : cord-003926-ycdaw2vh 4 1 Trop Trop NNP cord-003926-ycdaw2vh 4 2 Med Med NNP cord-003926-ycdaw2vh 4 3 Infect infect VB cord-003926-ycdaw2vh 4 4 Dis dis NN cord-003926-ycdaw2vh 4 5 DOI doi NN cord-003926-ycdaw2vh 5 1 : : : cord-003926-ycdaw2vh 5 2 10.3390 10.3390 CD cord-003926-ycdaw2vh 5 3 / / SYM cord-003926-ycdaw2vh 5 4 tropicalmed4030104 tropicalmed4030104 NNP cord-003926-ycdaw2vh 5 5 sha sha NNP cord-003926-ycdaw2vh 5 6 : : : cord-003926-ycdaw2vh 6 1 7a8f035845b43c4e3b01a3034bff85a7ae9b8dfc 7a8f035845b43c4e3b01a3034bff85a7ae9b8dfc NNP cord-003926-ycdaw2vh 6 2 doc_id doc_id CD cord-003926-ycdaw2vh 6 3 : : : cord-003926-ycdaw2vh 6 4 3926 3926 CD cord-003926-ycdaw2vh 6 5 cord_uid cord_uid NN cord-003926-ycdaw2vh 6 6 : : : cord-003926-ycdaw2vh 7 1 ycdaw2vh ycdaw2vh NNP cord-003926-ycdaw2vh 7 2 Zika Zika NNP cord-003926-ycdaw2vh 7 3 virus virus NN cord-003926-ycdaw2vh 7 4 is be VBZ cord-003926-ycdaw2vh 7 5 an an DT cord-003926-ycdaw2vh 7 6 emergent emergent JJ cord-003926-ycdaw2vh 7 7 pathogen pathogen NN cord-003926-ycdaw2vh 7 8 that that WDT cord-003926-ycdaw2vh 7 9 gained gain VBD cord-003926-ycdaw2vh 7 10 significant significant JJ cord-003926-ycdaw2vh 7 11 importance importance NN cord-003926-ycdaw2vh 7 12 during during IN cord-003926-ycdaw2vh 7 13 the the DT cord-003926-ycdaw2vh 7 14 epidemic epidemic NN cord-003926-ycdaw2vh 7 15 in in IN cord-003926-ycdaw2vh 7 16 South South NNP cord-003926-ycdaw2vh 7 17 and and CC cord-003926-ycdaw2vh 7 18 Central Central NNP cord-003926-ycdaw2vh 7 19 America America NNP cord-003926-ycdaw2vh 7 20 as as IN cord-003926-ycdaw2vh 7 21 unusual unusual JJ cord-003926-ycdaw2vh 7 22 and and CC cord-003926-ycdaw2vh 7 23 alarming alarming JJ cord-003926-ycdaw2vh 7 24 complications complication NNS cord-003926-ycdaw2vh 7 25 of of IN cord-003926-ycdaw2vh 7 26 infection infection NN cord-003926-ycdaw2vh 7 27 were be VBD cord-003926-ycdaw2vh 7 28 recognized recognize VBN cord-003926-ycdaw2vh 7 29 . . . cord-003926-ycdaw2vh 8 1 Although although IN cord-003926-ycdaw2vh 8 2 initially initially RB cord-003926-ycdaw2vh 8 3 considered consider VBD cord-003926-ycdaw2vh 8 4 a a DT cord-003926-ycdaw2vh 8 5 self self NN cord-003926-ycdaw2vh 8 6 - - HYPH cord-003926-ycdaw2vh 8 7 limited limit VBN cord-003926-ycdaw2vh 8 8 benign benign JJ cord-003926-ycdaw2vh 8 9 infection infection NN cord-003926-ycdaw2vh 8 10 , , , cord-003926-ycdaw2vh 8 11 a a DT cord-003926-ycdaw2vh 8 12 panoply panoply NN cord-003926-ycdaw2vh 8 13 of of IN cord-003926-ycdaw2vh 8 14 neurologic neurologic JJ cord-003926-ycdaw2vh 8 15 complications complication NNS cord-003926-ycdaw2vh 8 16 were be VBD cord-003926-ycdaw2vh 8 17 recognized recognize VBN cord-003926-ycdaw2vh 8 18 including include VBG cord-003926-ycdaw2vh 8 19 a a DT cord-003926-ycdaw2vh 8 20 Guillain Guillain NNP cord-003926-ycdaw2vh 8 21 – – : cord-003926-ycdaw2vh 8 22 Barré Barré NNP cord-003926-ycdaw2vh 8 23 - - HYPH cord-003926-ycdaw2vh 8 24 like like JJ cord-003926-ycdaw2vh 8 25 syndrome syndrome NN cord-003926-ycdaw2vh 8 26 and and CC cord-003926-ycdaw2vh 8 27 in in IN cord-003926-ycdaw2vh 8 28 - - HYPH cord-003926-ycdaw2vh 8 29 utero utero NN cord-003926-ycdaw2vh 8 30 fetal fetal JJ cord-003926-ycdaw2vh 8 31 infection infection NN cord-003926-ycdaw2vh 8 32 causing cause VBG cord-003926-ycdaw2vh 8 33 microcephaly microcephaly NNS cord-003926-ycdaw2vh 8 34 , , , cord-003926-ycdaw2vh 8 35 blindness blindness NN cord-003926-ycdaw2vh 8 36 , , , cord-003926-ycdaw2vh 8 37 and and CC cord-003926-ycdaw2vh 8 38 other other JJ cord-003926-ycdaw2vh 8 39 congenital congenital JJ cord-003926-ycdaw2vh 8 40 neurologic neurologic JJ cord-003926-ycdaw2vh 8 41 complications complication NNS cord-003926-ycdaw2vh 8 42 . . . cord-003926-ycdaw2vh 9 1 Numerous numerous JJ cord-003926-ycdaw2vh 9 2 Zika Zika NNP cord-003926-ycdaw2vh 9 3 virus virus NN cord-003926-ycdaw2vh 9 4 vaccines vaccine NNS cord-003926-ycdaw2vh 9 5 were be VBD cord-003926-ycdaw2vh 9 6 developed develop VBN cord-003926-ycdaw2vh 9 7 , , , cord-003926-ycdaw2vh 9 8 with with IN cord-003926-ycdaw2vh 9 9 nine nine CD cord-003926-ycdaw2vh 9 10 different different JJ cord-003926-ycdaw2vh 9 11 vaccines vaccine NNS cord-003926-ycdaw2vh 9 12 representing represent VBG cord-003926-ycdaw2vh 9 13 five five CD cord-003926-ycdaw2vh 9 14 different different JJ cord-003926-ycdaw2vh 9 15 platforms platform NNS cord-003926-ycdaw2vh 9 16 entered enter VBN cord-003926-ycdaw2vh 9 17 into into IN cord-003926-ycdaw2vh 9 18 clinical clinical JJ cord-003926-ycdaw2vh 9 19 trials trial NNS cord-003926-ycdaw2vh 9 20 , , , cord-003926-ycdaw2vh 9 21 one one CD cord-003926-ycdaw2vh 9 22 progressing progress VBG cord-003926-ycdaw2vh 9 23 to to IN cord-003926-ycdaw2vh 9 24 Phase Phase NNP cord-003926-ycdaw2vh 9 25 II II NNP cord-003926-ycdaw2vh 9 26 . . . cord-003926-ycdaw2vh 10 1 Here here RB cord-003926-ycdaw2vh 10 2 we -PRON- PRP cord-003926-ycdaw2vh 10 3 review review VBP cord-003926-ycdaw2vh 10 4 the the DT cord-003926-ycdaw2vh 10 5 current current JJ cord-003926-ycdaw2vh 10 6 landscape landscape NN cord-003926-ycdaw2vh 10 7 and and CC cord-003926-ycdaw2vh 10 8 challenges challenge NNS cord-003926-ycdaw2vh 10 9 confronting confront VBG cord-003926-ycdaw2vh 10 10 Zika Zika NNP cord-003926-ycdaw2vh 10 11 virus virus NN cord-003926-ycdaw2vh 10 12 vaccine vaccine NN cord-003926-ycdaw2vh 10 13 development development NN cord-003926-ycdaw2vh 10 14 . . . cord-003926-ycdaw2vh 11 1 The the DT cord-003926-ycdaw2vh 11 2 Zika Zika NNP cord-003926-ycdaw2vh 11 3 virus virus NN cord-003926-ycdaw2vh 11 4 , , , cord-003926-ycdaw2vh 11 5 discovered discover VBN cord-003926-ycdaw2vh 11 6 in in IN cord-003926-ycdaw2vh 11 7 Uganda Uganda NNP cord-003926-ycdaw2vh 11 8 in in IN cord-003926-ycdaw2vh 11 9 1947 1947 CD cord-003926-ycdaw2vh 11 10 [ [ -LRB- cord-003926-ycdaw2vh 11 11 1 1 CD cord-003926-ycdaw2vh 11 12 ] ] -RRB- cord-003926-ycdaw2vh 11 13 , , , cord-003926-ycdaw2vh 11 14 was be VBD cord-003926-ycdaw2vh 11 15 shown show VBN cord-003926-ycdaw2vh 11 16 to to TO cord-003926-ycdaw2vh 11 17 be be VB cord-003926-ycdaw2vh 11 18 endemic endemic JJ cord-003926-ycdaw2vh 11 19 through through IN cord-003926-ycdaw2vh 11 20 Sub Sub NNP cord-003926-ycdaw2vh 11 21 - - HYPH cord-003926-ycdaw2vh 11 22 Saharan Saharan NNP cord-003926-ycdaw2vh 11 23 Africa Africa NNP cord-003926-ycdaw2vh 11 24 and and CC cord-003926-ycdaw2vh 11 25 tropical tropical JJ cord-003926-ycdaw2vh 11 26 areas area NNS cord-003926-ycdaw2vh 11 27 of of IN cord-003926-ycdaw2vh 11 28 Southeastern Southeastern NNP cord-003926-ycdaw2vh 11 29 Asia Asia NNP cord-003926-ycdaw2vh 11 30 in in IN cord-003926-ycdaw2vh 11 31 studies study NNS cord-003926-ycdaw2vh 11 32 through through IN cord-003926-ycdaw2vh 11 33 the the DT cord-003926-ycdaw2vh 11 34 second second JJ cord-003926-ycdaw2vh 11 35 half half NN cord-003926-ycdaw2vh 11 36 of of IN cord-003926-ycdaw2vh 11 37 the the DT cord-003926-ycdaw2vh 11 38 20th 20th JJ cord-003926-ycdaw2vh 11 39 century century NN cord-003926-ycdaw2vh 11 40 [ [ -LRB- cord-003926-ycdaw2vh 11 41 2 2 CD cord-003926-ycdaw2vh 11 42 ] ] -RRB- cord-003926-ycdaw2vh 11 43 . . . cord-003926-ycdaw2vh 12 1 Isolated isolated JJ cord-003926-ycdaw2vh 12 2 outbreaks outbreak NNS cord-003926-ycdaw2vh 12 3 occurred occur VBD cord-003926-ycdaw2vh 12 4 in in IN cord-003926-ycdaw2vh 12 5 Yap Yap NNP cord-003926-ycdaw2vh 12 6 Island Island NNP cord-003926-ycdaw2vh 12 7 in in IN cord-003926-ycdaw2vh 12 8 2007 2007 CD cord-003926-ycdaw2vh 12 9 [ [ -LRB- cord-003926-ycdaw2vh 12 10 3 3 CD cord-003926-ycdaw2vh 12 11 ] ] -RRB- cord-003926-ycdaw2vh 12 12 and and CC cord-003926-ycdaw2vh 12 13 on on IN cord-003926-ycdaw2vh 12 14 French French NNP cord-003926-ycdaw2vh 12 15 Polynesia Polynesia NNP cord-003926-ycdaw2vh 12 16 in in IN cord-003926-ycdaw2vh 12 17 2014 2014 CD cord-003926-ycdaw2vh 12 18 [ [ -LRB- cord-003926-ycdaw2vh 12 19 4 4 CD cord-003926-ycdaw2vh 12 20 ] ] -RRB- cord-003926-ycdaw2vh 12 21 . . . cord-003926-ycdaw2vh 13 1 Starting start VBG cord-003926-ycdaw2vh 13 2 in in IN cord-003926-ycdaw2vh 13 3 mid-2015 mid-2015 NN cord-003926-ycdaw2vh 13 4 , , , cord-003926-ycdaw2vh 13 5 Zika Zika NNP cord-003926-ycdaw2vh 13 6 virus virus NN cord-003926-ycdaw2vh 13 7 infection infection NN cord-003926-ycdaw2vh 13 8 achieved achieve VBD cord-003926-ycdaw2vh 13 9 epidemic epidemic NN cord-003926-ycdaw2vh 13 10 status status NN cord-003926-ycdaw2vh 13 11 , , , cord-003926-ycdaw2vh 13 12 spreading spread VBG cord-003926-ycdaw2vh 13 13 rapidly rapidly RB cord-003926-ycdaw2vh 13 14 through through IN cord-003926-ycdaw2vh 13 15 South South NNP cord-003926-ycdaw2vh 13 16 America America NNP cord-003926-ycdaw2vh 13 17 , , , cord-003926-ycdaw2vh 13 18 Central Central NNP cord-003926-ycdaw2vh 13 19 America America NNP cord-003926-ycdaw2vh 13 20 , , , cord-003926-ycdaw2vh 13 21 and and CC cord-003926-ycdaw2vh 13 22 the the DT cord-003926-ycdaw2vh 13 23 Caribbean Caribbean NNP cord-003926-ycdaw2vh 13 24 Islands Islands NNPS cord-003926-ycdaw2vh 13 25 [ [ -LRB- cord-003926-ycdaw2vh 13 26 5 5 CD cord-003926-ycdaw2vh 13 27 ] ] -RRB- cord-003926-ycdaw2vh 13 28 . . . cord-003926-ycdaw2vh 14 1 It -PRON- PRP cord-003926-ycdaw2vh 14 2 was be VBD cord-003926-ycdaw2vh 14 3 soon soon RB cord-003926-ycdaw2vh 14 4 recognized recognize VBN cord-003926-ycdaw2vh 14 5 that that IN cord-003926-ycdaw2vh 14 6 Zika Zika NNP cord-003926-ycdaw2vh 14 7 virus virus NN cord-003926-ycdaw2vh 14 8 infection infection NN cord-003926-ycdaw2vh 14 9 occurring occur VBG cord-003926-ycdaw2vh 14 10 during during IN cord-003926-ycdaw2vh 14 11 pregnancy pregnancy NN cord-003926-ycdaw2vh 14 12 caused cause VBD cord-003926-ycdaw2vh 14 13 microcephaly microcephaly NNS cord-003926-ycdaw2vh 14 14 and and CC cord-003926-ycdaw2vh 14 15 other other JJ cord-003926-ycdaw2vh 14 16 congenital congenital JJ cord-003926-ycdaw2vh 14 17 disorders disorder NNS cord-003926-ycdaw2vh 14 18 in in IN cord-003926-ycdaw2vh 14 19 the the DT cord-003926-ycdaw2vh 14 20 developing develop VBG cord-003926-ycdaw2vh 14 21 fetus fetus NN cord-003926-ycdaw2vh 14 22 , , , cord-003926-ycdaw2vh 14 23 the the DT cord-003926-ycdaw2vh 14 24 latter latter JJ cord-003926-ycdaw2vh 14 25 being be VBG cord-003926-ycdaw2vh 14 26 the the DT cord-003926-ycdaw2vh 14 27 primary primary JJ cord-003926-ycdaw2vh 14 28 reason reason NN cord-003926-ycdaw2vh 14 29 for for IN cord-003926-ycdaw2vh 14 30 the the DT cord-003926-ycdaw2vh 14 31 World World NNP cord-003926-ycdaw2vh 14 32 Health Health NNP cord-003926-ycdaw2vh 14 33 Organization Organization NNP cord-003926-ycdaw2vh 14 34 ( ( -LRB- cord-003926-ycdaw2vh 14 35 WHO who WP cord-003926-ycdaw2vh 14 36 ) ) -RRB- cord-003926-ycdaw2vh 14 37 labelling label VBG cord-003926-ycdaw2vh 14 38 Zika Zika NNP cord-003926-ycdaw2vh 14 39 as as IN cord-003926-ycdaw2vh 14 40 an an DT cord-003926-ycdaw2vh 14 41 international international JJ cord-003926-ycdaw2vh 14 42 threat threat NN cord-003926-ycdaw2vh 14 43 in in IN cord-003926-ycdaw2vh 14 44 early early JJ cord-003926-ycdaw2vh 14 45 2016 2016 CD cord-003926-ycdaw2vh 14 46 . . . cord-003926-ycdaw2vh 15 1 Beginning begin VBG cord-003926-ycdaw2vh 15 2 in in IN cord-003926-ycdaw2vh 15 3 late late JJ cord-003926-ycdaw2vh 15 4 2015 2015 CD cord-003926-ycdaw2vh 15 5 , , , cord-003926-ycdaw2vh 15 6 numerous numerous JJ cord-003926-ycdaw2vh 15 7 academic academic JJ cord-003926-ycdaw2vh 15 8 labs lab NNS cord-003926-ycdaw2vh 15 9 and and CC cord-003926-ycdaw2vh 15 10 pharmaceutical pharmaceutical NN cord-003926-ycdaw2vh 15 11 companies company NNS cord-003926-ycdaw2vh 15 12 initiated initiate VBD cord-003926-ycdaw2vh 15 13 work work NN cord-003926-ycdaw2vh 15 14 to to TO cord-003926-ycdaw2vh 15 15 develop develop VB cord-003926-ycdaw2vh 15 16 a a DT cord-003926-ycdaw2vh 15 17 vaccine vaccine NN cord-003926-ycdaw2vh 15 18 against against IN cord-003926-ycdaw2vh 15 19 Zika Zika NNP cord-003926-ycdaw2vh 15 20 , , , cord-003926-ycdaw2vh 15 21 however however RB cord-003926-ycdaw2vh 15 22 , , , cord-003926-ycdaw2vh 15 23 by by IN cord-003926-ycdaw2vh 15 24 the the DT cord-003926-ycdaw2vh 15 25 time time NN cord-003926-ycdaw2vh 15 26 the the DT cord-003926-ycdaw2vh 15 27 first first JJ cord-003926-ycdaw2vh 15 28 vaccines vaccine NNS cord-003926-ycdaw2vh 15 29 entered enter VBD cord-003926-ycdaw2vh 15 30 clinical clinical JJ cord-003926-ycdaw2vh 15 31 trials trial NNS cord-003926-ycdaw2vh 15 32 , , , cord-003926-ycdaw2vh 15 33 the the DT cord-003926-ycdaw2vh 15 34 Zika Zika NNP cord-003926-ycdaw2vh 15 35 epidemic epidemic NN cord-003926-ycdaw2vh 15 36 had have VBD cord-003926-ycdaw2vh 15 37 started start VBN cord-003926-ycdaw2vh 15 38 to to TO cord-003926-ycdaw2vh 15 39 wane wane VB cord-003926-ycdaw2vh 15 40 creating create VBG cord-003926-ycdaw2vh 15 41 significant significant JJ cord-003926-ycdaw2vh 15 42 challenges challenge NNS cord-003926-ycdaw2vh 15 43 to to IN cord-003926-ycdaw2vh 15 44 vaccine vaccine NN cord-003926-ycdaw2vh 15 45 assessment assessment NN cord-003926-ycdaw2vh 15 46 [ [ -LRB- cord-003926-ycdaw2vh 15 47 6 6 CD cord-003926-ycdaw2vh 15 48 ] ] -RRB- cord-003926-ycdaw2vh 15 49 that that WDT cord-003926-ycdaw2vh 15 50 has have VBZ cord-003926-ycdaw2vh 15 51 engendered engender VBN cord-003926-ycdaw2vh 15 52 discussion discussion NN cord-003926-ycdaw2vh 15 53 of of IN cord-003926-ycdaw2vh 15 54 other other JJ cord-003926-ycdaw2vh 15 55 regulatory regulatory JJ cord-003926-ycdaw2vh 15 56 pathways pathway NNS cord-003926-ycdaw2vh 15 57 to to TO cord-003926-ycdaw2vh 15 58 licensure licensure VB cord-003926-ycdaw2vh 15 59 [ [ -LRB- cord-003926-ycdaw2vh 15 60 7 7 CD cord-003926-ycdaw2vh 15 61 ] ] -RRB- cord-003926-ycdaw2vh 15 62 . . . cord-003926-ycdaw2vh 16 1 In in IN cord-003926-ycdaw2vh 16 2 this this DT cord-003926-ycdaw2vh 16 3 paper paper NN cord-003926-ycdaw2vh 16 4 , , , cord-003926-ycdaw2vh 16 5 we -PRON- PRP cord-003926-ycdaw2vh 16 6 provide provide VBP cord-003926-ycdaw2vh 16 7 a a DT cord-003926-ycdaw2vh 16 8 brief brief JJ cord-003926-ycdaw2vh 16 9 update update NN cord-003926-ycdaw2vh 16 10 of of IN cord-003926-ycdaw2vh 16 11 current current JJ cord-003926-ycdaw2vh 16 12 progress progress NN cord-003926-ycdaw2vh 16 13 in in IN cord-003926-ycdaw2vh 16 14 Zika Zika NNP cord-003926-ycdaw2vh 16 15 virus virus NN cord-003926-ycdaw2vh 16 16 vaccine vaccine NN cord-003926-ycdaw2vh 16 17 development development NN cord-003926-ycdaw2vh 16 18 and and CC cord-003926-ycdaw2vh 16 19 explore explore VB cord-003926-ycdaw2vh 16 20 the the DT cord-003926-ycdaw2vh 16 21 challenges challenge NNS cord-003926-ycdaw2vh 16 22 to to IN cord-003926-ycdaw2vh 16 23 vaccine vaccine NN cord-003926-ycdaw2vh 16 24 assessment assessment NN cord-003926-ycdaw2vh 16 25 and and CC cord-003926-ycdaw2vh 16 26 eventual eventual JJ cord-003926-ycdaw2vh 16 27 licensure licensure NN cord-003926-ycdaw2vh 16 28 . . . cord-003926-ycdaw2vh 17 1 Zika Zika NNP cord-003926-ycdaw2vh 17 2 virus virus NN cord-003926-ycdaw2vh 17 3 infection infection NN cord-003926-ycdaw2vh 17 4 presents present VBZ cord-003926-ycdaw2vh 17 5 with with IN cord-003926-ycdaw2vh 17 6 a a DT cord-003926-ycdaw2vh 17 7 symptom symptom NN cord-003926-ycdaw2vh 17 8 complex complex NN cord-003926-ycdaw2vh 17 9 consisting consist VBG cord-003926-ycdaw2vh 17 10 of of IN cord-003926-ycdaw2vh 17 11 a a DT cord-003926-ycdaw2vh 17 12 diffuse diffuse JJ cord-003926-ycdaw2vh 17 13 maculo maculo NN cord-003926-ycdaw2vh 17 14 - - HYPH cord-003926-ycdaw2vh 17 15 papular papular JJ cord-003926-ycdaw2vh 17 16 rash rash NN cord-003926-ycdaw2vh 17 17 , , , cord-003926-ycdaw2vh 17 18 fever fever NN cord-003926-ycdaw2vh 17 19 , , , cord-003926-ycdaw2vh 17 20 asthenia asthenia NN cord-003926-ycdaw2vh 17 21 , , , cord-003926-ycdaw2vh 17 22 myalgias myalgias NNP cord-003926-ycdaw2vh 17 23 , , , cord-003926-ycdaw2vh 17 24 arthralgias arthralgias NNP cord-003926-ycdaw2vh 17 25 , , , cord-003926-ycdaw2vh 17 26 headache headache NN cord-003926-ycdaw2vh 17 27 , , , cord-003926-ycdaw2vh 17 28 and and CC cord-003926-ycdaw2vh 17 29 retroorbital retroorbital NNP cord-003926-ycdaw2vh 17 30 pain pain NN cord-003926-ycdaw2vh 17 31 . . . cord-003926-ycdaw2vh 18 1 The the DT cord-003926-ycdaw2vh 18 2 frequency frequency NN cord-003926-ycdaw2vh 18 3 and and CC cord-003926-ycdaw2vh 18 4 degree degree NN cord-003926-ycdaw2vh 18 5 of of IN cord-003926-ycdaw2vh 18 6 symptomatology symptomatology NN cord-003926-ycdaw2vh 18 7 has have VBZ cord-003926-ycdaw2vh 18 8 , , , cord-003926-ycdaw2vh 18 9 however however RB cord-003926-ycdaw2vh 18 10 , , , cord-003926-ycdaw2vh 18 11 varied varied JJ cord-003926-ycdaw2vh 18 12 between between IN cord-003926-ycdaw2vh 18 13 studies study NNS cord-003926-ycdaw2vh 18 14 . . . cord-003926-ycdaw2vh 19 1 A a DT cord-003926-ycdaw2vh 19 2 retrospective retrospective JJ cord-003926-ycdaw2vh 19 3 study study NN cord-003926-ycdaw2vh 19 4 immediately immediately RB cord-003926-ycdaw2vh 19 5 following follow VBG cord-003926-ycdaw2vh 19 6 the the DT cord-003926-ycdaw2vh 19 7 outbreak outbreak NN cord-003926-ycdaw2vh 19 8 on on IN cord-003926-ycdaw2vh 19 9 Yap Yap NNP cord-003926-ycdaw2vh 19 10 Island Island NNP cord-003926-ycdaw2vh 19 11 found find VBD cord-003926-ycdaw2vh 19 12 that that IN cord-003926-ycdaw2vh 19 13 only only RB cord-003926-ycdaw2vh 19 14 19 19 CD cord-003926-ycdaw2vh 19 15 % % NN cord-003926-ycdaw2vh 19 16 of of IN cord-003926-ycdaw2vh 19 17 survey survey NN cord-003926-ycdaw2vh 19 18 participants participant NNS cord-003926-ycdaw2vh 19 19 reported report VBD cord-003926-ycdaw2vh 19 20 symptoms symptom NNS cord-003926-ycdaw2vh 19 21 consistent consistent JJ cord-003926-ycdaw2vh 19 22 with with IN cord-003926-ycdaw2vh 19 23 Zika Zika NNP cord-003926-ycdaw2vh 19 24 virus virus NN cord-003926-ycdaw2vh 19 25 infection infection NN cord-003926-ycdaw2vh 19 26 [ [ -LRB- cord-003926-ycdaw2vh 19 27 3 3 CD cord-003926-ycdaw2vh 19 28 ] ] -RRB- cord-003926-ycdaw2vh 19 29 , , , cord-003926-ycdaw2vh 19 30 a a DT cord-003926-ycdaw2vh 19 31 figure figure NN cord-003926-ycdaw2vh 19 32 that that WDT cord-003926-ycdaw2vh 19 33 has have VBZ cord-003926-ycdaw2vh 19 34 been be VBN cord-003926-ycdaw2vh 19 35 cited cite VBN cord-003926-ycdaw2vh 19 36 to to TO cord-003926-ycdaw2vh 19 37 suggest suggest VB cord-003926-ycdaw2vh 19 38 that that IN cord-003926-ycdaw2vh 19 39 Zika Zika NNP cord-003926-ycdaw2vh 19 40 virus virus NN cord-003926-ycdaw2vh 19 41 infection infection NN cord-003926-ycdaw2vh 19 42 is be VBZ cord-003926-ycdaw2vh 19 43 asymptomatic asymptomatic JJ cord-003926-ycdaw2vh 19 44 in in IN cord-003926-ycdaw2vh 19 45 as as RB cord-003926-ycdaw2vh 19 46 many many JJ cord-003926-ycdaw2vh 19 47 as as IN cord-003926-ycdaw2vh 19 48 80 80 CD cord-003926-ycdaw2vh 19 49 % % NN cord-003926-ycdaw2vh 19 50 of of IN cord-003926-ycdaw2vh 19 51 individuals individual NNS cord-003926-ycdaw2vh 19 52 . . . cord-003926-ycdaw2vh 20 1 However however RB cord-003926-ycdaw2vh 20 2 , , , cord-003926-ycdaw2vh 20 3 of of IN cord-003926-ycdaw2vh 20 4 557 557 CD cord-003926-ycdaw2vh 20 5 individuals individual NNS cord-003926-ycdaw2vh 20 6 who who WP cord-003926-ycdaw2vh 20 7 provided provide VBD cord-003926-ycdaw2vh 20 8 blood blood NN cord-003926-ycdaw2vh 20 9 samples sample NNS cord-003926-ycdaw2vh 20 10 , , , cord-003926-ycdaw2vh 20 11 representing represent VBG cord-003926-ycdaw2vh 20 12 16 16 CD cord-003926-ycdaw2vh 20 13 % % NN cord-003926-ycdaw2vh 20 14 of of IN cord-003926-ycdaw2vh 20 15 households household NNS cord-003926-ycdaw2vh 20 16 , , , cord-003926-ycdaw2vh 20 17 38 38 CD cord-003926-ycdaw2vh 20 18 % % NN cord-003926-ycdaw2vh 20 19 were be VBD cord-003926-ycdaw2vh 20 20 symptomatic symptomatic JJ cord-003926-ycdaw2vh 20 21 [ [ -LRB- cord-003926-ycdaw2vh 20 22 3 3 CD cord-003926-ycdaw2vh 20 23 ] ] -RRB- cord-003926-ycdaw2vh 20 24 . . . cord-003926-ycdaw2vh 21 1 A a DT cord-003926-ycdaw2vh 21 2 second second JJ cord-003926-ycdaw2vh 21 3 retrospective retrospective JJ cord-003926-ycdaw2vh 21 4 study study NN cord-003926-ycdaw2vh 21 5 of of IN cord-003926-ycdaw2vh 21 6 the the DT cord-003926-ycdaw2vh 21 7 larger large JJR cord-003926-ycdaw2vh 21 8 outbreak outbreak NN cord-003926-ycdaw2vh 21 9 in in IN cord-003926-ycdaw2vh 21 10 French French NNP cord-003926-ycdaw2vh 21 11 Polynesia Polynesia NNP cord-003926-ycdaw2vh 21 12 [ [ -LRB- cord-003926-ycdaw2vh 21 13 8 8 CD cord-003926-ycdaw2vh 21 14 , , , cord-003926-ycdaw2vh 21 15 9 9 CD cord-003926-ycdaw2vh 21 16 ] ] -RRB- cord-003926-ycdaw2vh 21 17 , , , cord-003926-ycdaw2vh 21 18 similarly similarly RB cord-003926-ycdaw2vh 21 19 appeared appear VBD cord-003926-ycdaw2vh 21 20 to to TO cord-003926-ycdaw2vh 21 21 have have VB cord-003926-ycdaw2vh 21 22 a a DT cord-003926-ycdaw2vh 21 23 low low JJ cord-003926-ycdaw2vh 21 24 rate rate NN cord-003926-ycdaw2vh 21 25 of of IN cord-003926-ycdaw2vh 21 26 symptomatology symptomatology NN cord-003926-ycdaw2vh 21 27 based base VBN cord-003926-ycdaw2vh 21 28 on on IN cord-003926-ycdaw2vh 21 29 a a DT cord-003926-ycdaw2vh 21 30 sample sample NN cord-003926-ycdaw2vh 21 31 of of IN cord-003926-ycdaw2vh 21 32 blood blood NN cord-003926-ycdaw2vh 21 33 donors donor NNS cord-003926-ycdaw2vh 21 34 [ [ -LRB- cord-003926-ycdaw2vh 21 35 10 10 CD cord-003926-ycdaw2vh 21 36 ] ] -RRB- cord-003926-ycdaw2vh 21 37 . . . cord-003926-ycdaw2vh 22 1 However however RB cord-003926-ycdaw2vh 22 2 , , , cord-003926-ycdaw2vh 22 3 a a DT cord-003926-ycdaw2vh 22 4 subsequent subsequent JJ cord-003926-ycdaw2vh 22 5 seroprevalence seroprevalence NN cord-003926-ycdaw2vh 22 6 study study NN cord-003926-ycdaw2vh 22 7 found find VBD cord-003926-ycdaw2vh 22 8 that that IN cord-003926-ycdaw2vh 22 9 43 43 CD cord-003926-ycdaw2vh 22 10 % % NN cord-003926-ycdaw2vh 22 11 of of IN cord-003926-ycdaw2vh 22 12 those those DT cord-003926-ycdaw2vh 22 13 with with IN cord-003926-ycdaw2vh 22 14 evidence evidence NN cord-003926-ycdaw2vh 22 15 of of IN cord-003926-ycdaw2vh 22 16 prior prior JJ cord-003926-ycdaw2vh 22 17 infection infection NN cord-003926-ycdaw2vh 22 18 had have VBD cord-003926-ycdaw2vh 22 19 symptoms symptom NNS cord-003926-ycdaw2vh 22 20 consistent consistent JJ cord-003926-ycdaw2vh 22 21 with with IN cord-003926-ycdaw2vh 22 22 Zika Zika NNP cord-003926-ycdaw2vh 22 23 virus virus NN cord-003926-ycdaw2vh 22 24 infection infection NN cord-003926-ycdaw2vh 22 25 [ [ -LRB- cord-003926-ycdaw2vh 22 26 11 11 CD cord-003926-ycdaw2vh 22 27 ] ] -RRB- cord-003926-ycdaw2vh 22 28 . . . cord-003926-ycdaw2vh 23 1 A a DT cord-003926-ycdaw2vh 23 2 more more RBR cord-003926-ycdaw2vh 23 3 recent recent JJ cord-003926-ycdaw2vh 23 4 meta meta JJ cord-003926-ycdaw2vh 23 5 - - HYPH cord-003926-ycdaw2vh 23 6 analysis analysis NN cord-003926-ycdaw2vh 23 7 of of IN cord-003926-ycdaw2vh 23 8 23 23 CD cord-003926-ycdaw2vh 23 9 studies study NNS cord-003926-ycdaw2vh 23 10 noted note VBD cord-003926-ycdaw2vh 23 11 that that IN cord-003926-ycdaw2vh 23 12 between between IN cord-003926-ycdaw2vh 23 13 0 0 CD cord-003926-ycdaw2vh 23 14 and and CC cord-003926-ycdaw2vh 23 15 83 83 CD cord-003926-ycdaw2vh 23 16 % % NN cord-003926-ycdaw2vh 23 17 of of IN cord-003926-ycdaw2vh 23 18 cases case NNS cord-003926-ycdaw2vh 23 19 were be VBD cord-003926-ycdaw2vh 23 20 reported report VBN cord-003926-ycdaw2vh 23 21 as as IN cord-003926-ycdaw2vh 23 22 asymptomatic asymptomatic JJ cord-003926-ycdaw2vh 23 23 , , , cord-003926-ycdaw2vh 23 24 although although IN cord-003926-ycdaw2vh 23 25 as as IN cord-003926-ycdaw2vh 23 26 the the DT cord-003926-ycdaw2vh 23 27 authors author NNS cord-003926-ycdaw2vh 23 28 note note VBP cord-003926-ycdaw2vh 23 29 , , , cord-003926-ycdaw2vh 23 30 assessment assessment NN cord-003926-ycdaw2vh 23 31 of of IN cord-003926-ycdaw2vh 23 32 the the DT cord-003926-ycdaw2vh 23 33 prevalence prevalence NN cord-003926-ycdaw2vh 23 34 of of IN cord-003926-ycdaw2vh 23 35 symptoms symptom NNS cord-003926-ycdaw2vh 23 36 was be VBD cord-003926-ycdaw2vh 23 37 not not RB cord-003926-ycdaw2vh 23 38 the the DT cord-003926-ycdaw2vh 23 39 goal goal NN cord-003926-ycdaw2vh 23 40 of of IN cord-003926-ycdaw2vh 23 41 many many JJ cord-003926-ycdaw2vh 23 42 studies study NNS cord-003926-ycdaw2vh 23 43 [ [ -LRB- cord-003926-ycdaw2vh 23 44 12 12 CD cord-003926-ycdaw2vh 23 45 ] ] -RRB- cord-003926-ycdaw2vh 23 46 . . . cord-003926-ycdaw2vh 24 1 In in IN cord-003926-ycdaw2vh 24 2 adults adult NNS cord-003926-ycdaw2vh 24 3 , , , cord-003926-ycdaw2vh 24 4 the the DT cord-003926-ycdaw2vh 24 5 most most RBS cord-003926-ycdaw2vh 24 6 common common JJ cord-003926-ycdaw2vh 24 7 reported report VBN cord-003926-ycdaw2vh 24 8 complication complication NN cord-003926-ycdaw2vh 24 9 of of IN cord-003926-ycdaw2vh 24 10 Zika Zika NNP cord-003926-ycdaw2vh 24 11 virus virus NN cord-003926-ycdaw2vh 24 12 infection infection NN cord-003926-ycdaw2vh 24 13 is be VBZ cord-003926-ycdaw2vh 24 14 a a DT cord-003926-ycdaw2vh 24 15 Guillain Guillain NNP cord-003926-ycdaw2vh 24 16 - - HYPH cord-003926-ycdaw2vh 24 17 Barré Barré NNP cord-003926-ycdaw2vh 24 18 - - HYPH cord-003926-ycdaw2vh 24 19 like like JJ cord-003926-ycdaw2vh 24 20 illness illness NN cord-003926-ycdaw2vh 24 21 that that WDT cord-003926-ycdaw2vh 24 22 had have VBD cord-003926-ycdaw2vh 24 23 a a DT cord-003926-ycdaw2vh 24 24 prevalence prevalence NN cord-003926-ycdaw2vh 24 25 of of IN cord-003926-ycdaw2vh 24 26 0.24 0.24 CD cord-003926-ycdaw2vh 24 27 cases case NNS cord-003926-ycdaw2vh 24 28 per per IN cord-003926-ycdaw2vh 24 29 1000 1000 CD cord-003926-ycdaw2vh 24 30 cases case NNS cord-003926-ycdaw2vh 24 31 of of IN cord-003926-ycdaw2vh 24 32 infection infection NN cord-003926-ycdaw2vh 24 33 in in IN cord-003926-ycdaw2vh 24 34 the the DT cord-003926-ycdaw2vh 24 35 French french JJ cord-003926-ycdaw2vh 24 36 Polynesian polynesian JJ cord-003926-ycdaw2vh 24 37 epidemic epidemic NN cord-003926-ycdaw2vh 24 38 [ [ -LRB- cord-003926-ycdaw2vh 24 39 13 13 CD cord-003926-ycdaw2vh 24 40 ] ] -RRB- cord-003926-ycdaw2vh 24 41 . . . cord-003926-ycdaw2vh 25 1 Of of IN cord-003926-ycdaw2vh 25 2 interest interest NN cord-003926-ycdaw2vh 25 3 , , , cord-003926-ycdaw2vh 25 4 a a DT cord-003926-ycdaw2vh 25 5 recent recent JJ cord-003926-ycdaw2vh 25 6 meta meta JJ cord-003926-ycdaw2vh 25 7 - - HYPH cord-003926-ycdaw2vh 25 8 analysis analysis NN cord-003926-ycdaw2vh 25 9 has have VBZ cord-003926-ycdaw2vh 25 10 questioned question VBN cord-003926-ycdaw2vh 25 11 this this DT cord-003926-ycdaw2vh 25 12 causal causal NN cord-003926-ycdaw2vh 25 13 association association NN cord-003926-ycdaw2vh 25 14 [ [ -LRB- cord-003926-ycdaw2vh 25 15 14 14 CD cord-003926-ycdaw2vh 25 16 ] ] -RRB- cord-003926-ycdaw2vh 25 17 . . . cord-003926-ycdaw2vh 26 1 Other other JJ cord-003926-ycdaw2vh 26 2 less less RBR cord-003926-ycdaw2vh 26 3 common common JJ cord-003926-ycdaw2vh 26 4 reported report VBN cord-003926-ycdaw2vh 26 5 neurologic neurologic JJ cord-003926-ycdaw2vh 26 6 complications complication NNS cord-003926-ycdaw2vh 26 7 in in IN cord-003926-ycdaw2vh 26 8 adults adult NNS cord-003926-ycdaw2vh 26 9 include include VBP cord-003926-ycdaw2vh 26 10 meningoencephalitis meningoencephalitis NNP cord-003926-ycdaw2vh 26 11 [ [ -LRB- cord-003926-ycdaw2vh 26 12 15 15 CD cord-003926-ycdaw2vh 26 13 ] ] -RRB- cord-003926-ycdaw2vh 26 14 and and CC cord-003926-ycdaw2vh 26 15 an an DT cord-003926-ycdaw2vh 26 16 ADEM ADEM NNP cord-003926-ycdaw2vh 26 17 illness illness NN cord-003926-ycdaw2vh 26 18 . . . cord-003926-ycdaw2vh 27 1 In in IN cord-003926-ycdaw2vh 27 2 contrast contrast NN cord-003926-ycdaw2vh 27 3 , , , cord-003926-ycdaw2vh 27 4 infection infection NN cord-003926-ycdaw2vh 27 5 during during IN cord-003926-ycdaw2vh 27 6 pregnancy pregnancy NN cord-003926-ycdaw2vh 27 7 has have VBZ cord-003926-ycdaw2vh 27 8 been be VBN cord-003926-ycdaw2vh 27 9 associated associate VBN cord-003926-ycdaw2vh 27 10 with with IN cord-003926-ycdaw2vh 27 11 fetal fetal JJ cord-003926-ycdaw2vh 27 12 microcephaly microcephaly NNS cord-003926-ycdaw2vh 27 13 and and CC cord-003926-ycdaw2vh 27 14 a a DT cord-003926-ycdaw2vh 27 15 number number NN cord-003926-ycdaw2vh 27 16 of of IN cord-003926-ycdaw2vh 27 17 other other JJ cord-003926-ycdaw2vh 27 18 congenital congenital JJ cord-003926-ycdaw2vh 27 19 illnesses illness NNS cord-003926-ycdaw2vh 27 20 including include VBG cord-003926-ycdaw2vh 27 21 visual visual JJ cord-003926-ycdaw2vh 27 22 deficits deficit NNS cord-003926-ycdaw2vh 27 23 , , , cord-003926-ycdaw2vh 27 24 hearing hear VBG cord-003926-ycdaw2vh 27 25 disorders disorder NNS cord-003926-ycdaw2vh 27 26 , , , cord-003926-ycdaw2vh 27 27 neural neural JJ cord-003926-ycdaw2vh 27 28 calcifications calcification NNS cord-003926-ycdaw2vh 27 29 , , , cord-003926-ycdaw2vh 27 30 learning learn VBG cord-003926-ycdaw2vh 27 31 disabilities disability NNS cord-003926-ycdaw2vh 27 32 , , , cord-003926-ycdaw2vh 27 33 and and CC cord-003926-ycdaw2vh 27 34 arthrogryposis arthrogryposis NN cord-003926-ycdaw2vh 27 35 that that WDT cord-003926-ycdaw2vh 27 36 may may MD cord-003926-ycdaw2vh 27 37 affect affect VB cord-003926-ycdaw2vh 27 38 as as RB cord-003926-ycdaw2vh 27 39 many many JJ cord-003926-ycdaw2vh 27 40 as as IN cord-003926-ycdaw2vh 27 41 30 30 CD cord-003926-ycdaw2vh 27 42 % % NN cord-003926-ycdaw2vh 27 43 children child NNS cord-003926-ycdaw2vh 27 44 born bear VBN cord-003926-ycdaw2vh 27 45 to to IN cord-003926-ycdaw2vh 27 46 mothers mother NNS cord-003926-ycdaw2vh 27 47 infected infect VBN cord-003926-ycdaw2vh 27 48 during during IN cord-003926-ycdaw2vh 27 49 pregnancy pregnancy NN cord-003926-ycdaw2vh 27 50 [ [ -LRB- cord-003926-ycdaw2vh 27 51 16 16 CD cord-003926-ycdaw2vh 27 52 ] ] -RRB- cord-003926-ycdaw2vh 27 53 [ [ -LRB- cord-003926-ycdaw2vh 27 54 17 17 CD cord-003926-ycdaw2vh 27 55 ] ] -RRB- cord-003926-ycdaw2vh 27 56 [ [ -LRB- cord-003926-ycdaw2vh 27 57 18 18 CD cord-003926-ycdaw2vh 27 58 ] ] -RRB- cord-003926-ycdaw2vh 27 59 [ [ -LRB- cord-003926-ycdaw2vh 27 60 19 19 CD cord-003926-ycdaw2vh 27 61 ] ] -RRB- cord-003926-ycdaw2vh 27 62 [ [ -LRB- cord-003926-ycdaw2vh 27 63 20 20 CD cord-003926-ycdaw2vh 27 64 ] ] -RRB- cord-003926-ycdaw2vh 27 65 [ [ -LRB- cord-003926-ycdaw2vh 27 66 21 21 CD cord-003926-ycdaw2vh 27 67 ] ] -RRB- cord-003926-ycdaw2vh 27 68 . . . cord-003926-ycdaw2vh 28 1 Additionally additionally RB cord-003926-ycdaw2vh 28 2 , , , cord-003926-ycdaw2vh 28 3 Zika Zika NNP cord-003926-ycdaw2vh 28 4 can can MD cord-003926-ycdaw2vh 28 5 directly directly RB cord-003926-ycdaw2vh 28 6 invade invade VB cord-003926-ycdaw2vh 28 7 the the DT cord-003926-ycdaw2vh 28 8 placenta placenta NN cord-003926-ycdaw2vh 28 9 and and CC cord-003926-ycdaw2vh 28 10 has have VBZ cord-003926-ycdaw2vh 28 11 been be VBN cord-003926-ycdaw2vh 28 12 associated associate VBN cord-003926-ycdaw2vh 28 13 with with IN cord-003926-ycdaw2vh 28 14 prolonged prolong VBN cord-003926-ycdaw2vh 28 15 maternal maternal JJ cord-003926-ycdaw2vh 28 16 viremia viremia NN cord-003926-ycdaw2vh 28 17 [ [ -LRB- cord-003926-ycdaw2vh 28 18 22 22 CD cord-003926-ycdaw2vh 28 19 ] ] -RRB- cord-003926-ycdaw2vh 28 20 [ [ -LRB- cord-003926-ycdaw2vh 28 21 23 23 CD cord-003926-ycdaw2vh 28 22 ] ] -RRB- cord-003926-ycdaw2vh 28 23 [ [ -LRB- cord-003926-ycdaw2vh 28 24 24 24 CD cord-003926-ycdaw2vh 28 25 ] ] -RRB- cord-003926-ycdaw2vh 28 26 . . . cord-003926-ycdaw2vh 29 1 Zika Zika NNP cord-003926-ycdaw2vh 29 2 virus virus NN cord-003926-ycdaw2vh 29 3 can can MD cord-003926-ycdaw2vh 29 4 also also RB cord-003926-ycdaw2vh 29 5 be be VB cord-003926-ycdaw2vh 29 6 transmitted transmit VBN cord-003926-ycdaw2vh 29 7 through through IN cord-003926-ycdaw2vh 29 8 sexual sexual JJ cord-003926-ycdaw2vh 29 9 contact contact NN cord-003926-ycdaw2vh 29 10 , , , cord-003926-ycdaw2vh 29 11 first first RB cord-003926-ycdaw2vh 29 12 reported report VBN cord-003926-ycdaw2vh 29 13 for for IN cord-003926-ycdaw2vh 29 14 a a DT cord-003926-ycdaw2vh 29 15 researcher researcher NN cord-003926-ycdaw2vh 29 16 returning return VBG cord-003926-ycdaw2vh 29 17 from from IN cord-003926-ycdaw2vh 29 18 Senegal Senegal NNP cord-003926-ycdaw2vh 29 19 in in IN cord-003926-ycdaw2vh 29 20 2008 2008 CD cord-003926-ycdaw2vh 29 21 [ [ -LRB- cord-003926-ycdaw2vh 29 22 25 25 CD cord-003926-ycdaw2vh 29 23 ] ] -RRB- cord-003926-ycdaw2vh 29 24 . . . cord-003926-ycdaw2vh 30 1 Numerous numerous JJ cord-003926-ycdaw2vh 30 2 subsequent subsequent JJ cord-003926-ycdaw2vh 30 3 case case NN cord-003926-ycdaw2vh 30 4 reports report NNS cord-003926-ycdaw2vh 30 5 were be VBD cord-003926-ycdaw2vh 30 6 published publish VBN cord-003926-ycdaw2vh 30 7 among among IN cord-003926-ycdaw2vh 30 8 travelers traveler NNS cord-003926-ycdaw2vh 30 9 as as IN cord-003926-ycdaw2vh 30 10 part part NN cord-003926-ycdaw2vh 30 11 of of IN cord-003926-ycdaw2vh 30 12 the the DT cord-003926-ycdaw2vh 30 13 epidemic epidemic NN cord-003926-ycdaw2vh 30 14 affecting affect VBG cord-003926-ycdaw2vh 30 15 the the DT cord-003926-ycdaw2vh 30 16 Americas Americas NNPS cord-003926-ycdaw2vh 30 17 [ [ -LRB- cord-003926-ycdaw2vh 30 18 26 26 CD cord-003926-ycdaw2vh 30 19 ] ] -RRB- cord-003926-ycdaw2vh 30 20 . . . cord-003926-ycdaw2vh 31 1 The the DT cord-003926-ycdaw2vh 31 2 frequency frequency NN cord-003926-ycdaw2vh 31 3 of of IN cord-003926-ycdaw2vh 31 4 sexual sexual JJ cord-003926-ycdaw2vh 31 5 transmission transmission NN cord-003926-ycdaw2vh 31 6 in in IN cord-003926-ycdaw2vh 31 7 endemic endemic JJ cord-003926-ycdaw2vh 31 8 regions region NNS cord-003926-ycdaw2vh 31 9 is be VBZ cord-003926-ycdaw2vh 31 10 unknown unknown JJ cord-003926-ycdaw2vh 31 11 and and CC cord-003926-ycdaw2vh 31 12 could could MD cord-003926-ycdaw2vh 31 13 not not RB cord-003926-ycdaw2vh 31 14 be be VB cord-003926-ycdaw2vh 31 15 differentiated differentiate VBN cord-003926-ycdaw2vh 31 16 from from IN cord-003926-ycdaw2vh 31 17 mosquito mosquito NN cord-003926-ycdaw2vh 31 18 - - HYPH cord-003926-ycdaw2vh 31 19 borne bear VBN cord-003926-ycdaw2vh 31 20 transmission transmission NN cord-003926-ycdaw2vh 31 21 . . . cord-003926-ycdaw2vh 32 1 Zika Zika NNP cord-003926-ycdaw2vh 32 2 virus virus NN cord-003926-ycdaw2vh 32 3 carriage carriage NN cord-003926-ycdaw2vh 32 4 in in IN cord-003926-ycdaw2vh 32 5 the the DT cord-003926-ycdaw2vh 32 6 male male JJ cord-003926-ycdaw2vh 32 7 urogenital urogenital JJ cord-003926-ycdaw2vh 32 8 tract tract NN cord-003926-ycdaw2vh 32 9 is be VBZ cord-003926-ycdaw2vh 32 10 common common JJ cord-003926-ycdaw2vh 32 11 through through IN cord-003926-ycdaw2vh 32 12 90 90 CD cord-003926-ycdaw2vh 32 13 days day NNS cord-003926-ycdaw2vh 32 14 post post NN cord-003926-ycdaw2vh 32 15 infection infection NN cord-003926-ycdaw2vh 32 16 and and CC cord-003926-ycdaw2vh 32 17 may may MD cord-003926-ycdaw2vh 32 18 persist persist VB cord-003926-ycdaw2vh 32 19 in in IN cord-003926-ycdaw2vh 32 20 some some DT cord-003926-ycdaw2vh 32 21 to to IN cord-003926-ycdaw2vh 32 22 9 9 CD cord-003926-ycdaw2vh 32 23 months month NNS cord-003926-ycdaw2vh 32 24 [ [ -LRB- cord-003926-ycdaw2vh 32 25 27 27 CD cord-003926-ycdaw2vh 32 26 ] ] -RRB- cord-003926-ycdaw2vh 32 27 . . . cord-003926-ycdaw2vh 33 1 In in IN cord-003926-ycdaw2vh 33 2 mice mouse NNS cord-003926-ycdaw2vh 33 3 , , , cord-003926-ycdaw2vh 33 4 Zika Zika NNP cord-003926-ycdaw2vh 33 5 virus virus NN cord-003926-ycdaw2vh 33 6 infection infection NN cord-003926-ycdaw2vh 33 7 causes cause VBZ cord-003926-ycdaw2vh 33 8 testicular testicular JJ cord-003926-ycdaw2vh 33 9 atrophy atrophy NN cord-003926-ycdaw2vh 33 10 and and CC cord-003926-ycdaw2vh 33 11 significantly significantly RB cord-003926-ycdaw2vh 33 12 decreases decrease VBZ cord-003926-ycdaw2vh 33 13 spermatic spermatic JJ cord-003926-ycdaw2vh 33 14 function function NN cord-003926-ycdaw2vh 33 15 and and CC cord-003926-ycdaw2vh 33 16 fertility fertility NN cord-003926-ycdaw2vh 33 17 rates rate NNS cord-003926-ycdaw2vh 33 18 [ [ -LRB- cord-003926-ycdaw2vh 33 19 28 28 CD cord-003926-ycdaw2vh 33 20 ] ] -RRB- cord-003926-ycdaw2vh 34 1 [ [ -LRB- cord-003926-ycdaw2vh 34 2 29 29 CD cord-003926-ycdaw2vh 34 3 ] ] -RRB- cord-003926-ycdaw2vh 34 4 [ [ -LRB- cord-003926-ycdaw2vh 34 5 30 30 CD cord-003926-ycdaw2vh 34 6 ] ] -RRB- cord-003926-ycdaw2vh 34 7 . . . cord-003926-ycdaw2vh 35 1 In in IN cord-003926-ycdaw2vh 35 2 one one CD cord-003926-ycdaw2vh 35 3 study study NN cord-003926-ycdaw2vh 35 4 of of IN cord-003926-ycdaw2vh 35 5 a a DT cord-003926-ycdaw2vh 35 6 Zika Zika NNP cord-003926-ycdaw2vh 35 7 virus virus NN cord-003926-ycdaw2vh 35 8 DNA dna NN cord-003926-ycdaw2vh 35 9 vaccine vaccine NN cord-003926-ycdaw2vh 35 10 , , , cord-003926-ycdaw2vh 35 11 the the DT cord-003926-ycdaw2vh 35 12 adverse adverse JJ cord-003926-ycdaw2vh 35 13 effects effect NNS cord-003926-ycdaw2vh 35 14 in in IN cord-003926-ycdaw2vh 35 15 the the DT cord-003926-ycdaw2vh 35 16 male male JJ cord-003926-ycdaw2vh 35 17 reproductive reproductive JJ cord-003926-ycdaw2vh 35 18 system system NN cord-003926-ycdaw2vh 35 19 were be VBD cord-003926-ycdaw2vh 35 20 prevented prevent VBN cord-003926-ycdaw2vh 35 21 by by IN cord-003926-ycdaw2vh 35 22 vaccination vaccination NN cord-003926-ycdaw2vh 35 23 [ [ -LRB- cord-003926-ycdaw2vh 35 24 30 30 CD cord-003926-ycdaw2vh 35 25 ] ] -RRB- cord-003926-ycdaw2vh 35 26 . . . cord-003926-ycdaw2vh 36 1 The the DT cord-003926-ycdaw2vh 36 2 question question NN cord-003926-ycdaw2vh 36 3 of of IN cord-003926-ycdaw2vh 36 4 whether whether IN cord-003926-ycdaw2vh 36 5 Zika Zika NNP cord-003926-ycdaw2vh 36 6 virus virus NN cord-003926-ycdaw2vh 36 7 can can MD cord-003926-ycdaw2vh 36 8 adversely adversely RB cord-003926-ycdaw2vh 36 9 affect affect VB cord-003926-ycdaw2vh 36 10 human human JJ cord-003926-ycdaw2vh 36 11 reproductive reproductive JJ cord-003926-ycdaw2vh 36 12 potential potential NN cord-003926-ycdaw2vh 36 13 and and CC cord-003926-ycdaw2vh 36 14 , , , cord-003926-ycdaw2vh 36 15 if if IN cord-003926-ycdaw2vh 36 16 so so RB cord-003926-ycdaw2vh 36 17 , , , cord-003926-ycdaw2vh 36 18 whether whether IN cord-003926-ycdaw2vh 36 19 such such JJ cord-003926-ycdaw2vh 36 20 effects effect NNS cord-003926-ycdaw2vh 36 21 would would MD cord-003926-ycdaw2vh 36 22 be be VB cord-003926-ycdaw2vh 36 23 age age NN cord-003926-ycdaw2vh 36 24 - - HYPH cord-003926-ycdaw2vh 36 25 related relate VBN cord-003926-ycdaw2vh 36 26 is be VBZ cord-003926-ycdaw2vh 36 27 unknown unknown JJ cord-003926-ycdaw2vh 36 28 . . . cord-003926-ycdaw2vh 37 1 Females female NNS cord-003926-ycdaw2vh 37 2 may may MD cord-003926-ycdaw2vh 37 3 also also RB cord-003926-ycdaw2vh 37 4 excrete excrete VB cord-003926-ycdaw2vh 37 5 Zika Zika NNP cord-003926-ycdaw2vh 37 6 virus virus NN cord-003926-ycdaw2vh 37 7 RNA rna NN cord-003926-ycdaw2vh 37 8 for for IN cord-003926-ycdaw2vh 37 9 extended extended JJ cord-003926-ycdaw2vh 37 10 times time NNS cord-003926-ycdaw2vh 37 11 . . . cord-003926-ycdaw2vh 38 1 A a DT cord-003926-ycdaw2vh 38 2 prospective prospective JJ cord-003926-ycdaw2vh 38 3 study study NN cord-003926-ycdaw2vh 38 4 of of IN cord-003926-ycdaw2vh 38 5 five five CD cord-003926-ycdaw2vh 38 6 women woman NNS cord-003926-ycdaw2vh 38 7 showed show VBD cord-003926-ycdaw2vh 38 8 that that IN cord-003926-ycdaw2vh 38 9 Zika Zika NNP cord-003926-ycdaw2vh 38 10 RNA RNA NNP cord-003926-ycdaw2vh 38 11 was be VBD cord-003926-ycdaw2vh 38 12 detected detect VBN cord-003926-ycdaw2vh 38 13 in in IN cord-003926-ycdaw2vh 38 14 vaginal vaginal JJ cord-003926-ycdaw2vh 38 15 fluid fluid NN cord-003926-ycdaw2vh 38 16 for for IN cord-003926-ycdaw2vh 38 17 as as RB cord-003926-ycdaw2vh 38 18 long long JJ cord-003926-ycdaw2vh 38 19 as as IN cord-003926-ycdaw2vh 38 20 6 6 CD cord-003926-ycdaw2vh 38 21 months month NNS cord-003926-ycdaw2vh 38 22 and and CC cord-003926-ycdaw2vh 38 23 a a DT cord-003926-ycdaw2vh 38 24 month month NN cord-003926-ycdaw2vh 38 25 or or CC cord-003926-ycdaw2vh 38 26 more more JJR cord-003926-ycdaw2vh 38 27 in in IN cord-003926-ycdaw2vh 38 28 three three CD cord-003926-ycdaw2vh 38 29 of of IN cord-003926-ycdaw2vh 38 30 the the DT cord-003926-ycdaw2vh 38 31 five five CD cord-003926-ycdaw2vh 38 32 [ [ -LRB- cord-003926-ycdaw2vh 38 33 31 31 CD cord-003926-ycdaw2vh 38 34 ] ] -RRB- cord-003926-ycdaw2vh 38 35 . . . cord-003926-ycdaw2vh 39 1 Murine murine JJ cord-003926-ycdaw2vh 39 2 studies study NNS cord-003926-ycdaw2vh 39 3 showed show VBD cord-003926-ycdaw2vh 39 4 that that IN cord-003926-ycdaw2vh 39 5 Zika Zika NNP cord-003926-ycdaw2vh 39 6 virus virus NN cord-003926-ycdaw2vh 39 7 caused cause VBD cord-003926-ycdaw2vh 39 8 infection infection NN cord-003926-ycdaw2vh 39 9 of of IN cord-003926-ycdaw2vh 39 10 the the DT cord-003926-ycdaw2vh 39 11 ovaries ovary NNS cord-003926-ycdaw2vh 39 12 of of IN cord-003926-ycdaw2vh 39 13 non non JJ cord-003926-ycdaw2vh 39 14 - - JJ cord-003926-ycdaw2vh 39 15 immunosuppressed immunosuppressed JJ cord-003926-ycdaw2vh 39 16 C57Bl/6 C57Bl/6 NNPS cord-003926-ycdaw2vh 39 17 mice mouse NNS cord-003926-ycdaw2vh 39 18 and and CC cord-003926-ycdaw2vh 39 19 induced induce VBD cord-003926-ycdaw2vh 39 20 a a DT cord-003926-ycdaw2vh 39 21 T t NN cord-003926-ycdaw2vh 39 22 - - HYPH cord-003926-ycdaw2vh 39 23 cell cell NN cord-003926-ycdaw2vh 39 24 inflammatory inflammatory JJ cord-003926-ycdaw2vh 39 25 reaction reaction NN cord-003926-ycdaw2vh 39 26 , , , cord-003926-ycdaw2vh 39 27 but but CC cord-003926-ycdaw2vh 39 28 without without IN cord-003926-ycdaw2vh 39 29 affecting affect VBG cord-003926-ycdaw2vh 39 30 reproductive reproductive JJ cord-003926-ycdaw2vh 39 31 potential potential NN cord-003926-ycdaw2vh 39 32 [ [ -LRB- cord-003926-ycdaw2vh 39 33 32 32 CD cord-003926-ycdaw2vh 39 34 ] ] -RRB- cord-003926-ycdaw2vh 39 35 . . . cord-003926-ycdaw2vh 40 1 In in IN cord-003926-ycdaw2vh 40 2 contrast contrast NN cord-003926-ycdaw2vh 40 3 to to IN cord-003926-ycdaw2vh 40 4 the the DT cord-003926-ycdaw2vh 40 5 above above JJ cord-003926-ycdaw2vh 40 6 human human JJ cord-003926-ycdaw2vh 40 7 study study NN cord-003926-ycdaw2vh 40 8 , , , cord-003926-ycdaw2vh 40 9 female female JJ cord-003926-ycdaw2vh 40 10 macaques macaque NNS cord-003926-ycdaw2vh 40 11 rapidly rapidly RB cord-003926-ycdaw2vh 40 12 cleared clear VBD cord-003926-ycdaw2vh 40 13 virus virus NN cord-003926-ycdaw2vh 40 14 from from IN cord-003926-ycdaw2vh 40 15 the the DT cord-003926-ycdaw2vh 40 16 genital genital JJ cord-003926-ycdaw2vh 40 17 tract tract NN cord-003926-ycdaw2vh 40 18 [ [ -LRB- cord-003926-ycdaw2vh 40 19 33 33 CD cord-003926-ycdaw2vh 40 20 ] ] -RRB- cord-003926-ycdaw2vh 40 21 . . . cord-003926-ycdaw2vh 41 1 Thus thus RB cord-003926-ycdaw2vh 41 2 , , , cord-003926-ycdaw2vh 41 3 while while IN cord-003926-ycdaw2vh 41 4 Zika Zika NNP cord-003926-ycdaw2vh 41 5 virus virus NN cord-003926-ycdaw2vh 41 6 infection infection NN cord-003926-ycdaw2vh 41 7 is be VBZ cord-003926-ycdaw2vh 41 8 mildly mildly RB cord-003926-ycdaw2vh 41 9 symptomatic symptomatic JJ cord-003926-ycdaw2vh 41 10 and and CC cord-003926-ycdaw2vh 41 11 self self NN cord-003926-ycdaw2vh 41 12 - - HYPH cord-003926-ycdaw2vh 41 13 limited limit VBN cord-003926-ycdaw2vh 41 14 for for IN cord-003926-ycdaw2vh 41 15 the the DT cord-003926-ycdaw2vh 41 16 vast vast JJ cord-003926-ycdaw2vh 41 17 majority majority NN cord-003926-ycdaw2vh 41 18 of of IN cord-003926-ycdaw2vh 41 19 individuals individual NNS cord-003926-ycdaw2vh 41 20 , , , cord-003926-ycdaw2vh 41 21 with with IN cord-003926-ycdaw2vh 41 22 infrequent infrequent JJ cord-003926-ycdaw2vh 41 23 neurologic neurologic JJ cord-003926-ycdaw2vh 41 24 complications complication NNS cord-003926-ycdaw2vh 41 25 in in IN cord-003926-ycdaw2vh 41 26 adults adult NNS cord-003926-ycdaw2vh 41 27 , , , cord-003926-ycdaw2vh 41 28 vaccination vaccination NN cord-003926-ycdaw2vh 41 29 of of IN cord-003926-ycdaw2vh 41 30 the the DT cord-003926-ycdaw2vh 41 31 general general JJ cord-003926-ycdaw2vh 41 32 population population NN cord-003926-ycdaw2vh 41 33 may may MD cord-003926-ycdaw2vh 41 34 not not RB cord-003926-ycdaw2vh 41 35 be be VB cord-003926-ycdaw2vh 41 36 warranted warrant VBN cord-003926-ycdaw2vh 41 37 . . . cord-003926-ycdaw2vh 42 1 However however RB cord-003926-ycdaw2vh 42 2 , , , cord-003926-ycdaw2vh 42 3 vaccination vaccination NN cord-003926-ycdaw2vh 42 4 of of IN cord-003926-ycdaw2vh 42 5 females female NNS cord-003926-ycdaw2vh 42 6 at at IN cord-003926-ycdaw2vh 42 7 or or CC cord-003926-ycdaw2vh 42 8 entering enter VBG cord-003926-ycdaw2vh 42 9 reproductive reproductive JJ cord-003926-ycdaw2vh 42 10 age age NN cord-003926-ycdaw2vh 42 11 and and CC cord-003926-ycdaw2vh 42 12 their -PRON- PRP$ cord-003926-ycdaw2vh 42 13 male male JJ cord-003926-ycdaw2vh 42 14 partners partner NNS cord-003926-ycdaw2vh 42 15 is be VBZ cord-003926-ycdaw2vh 42 16 prudent prudent JJ cord-003926-ycdaw2vh 42 17 . . . cord-003926-ycdaw2vh 43 1 As as IN cord-003926-ycdaw2vh 43 2 discussed discuss VBN cord-003926-ycdaw2vh 43 3 previously previously RB cord-003926-ycdaw2vh 43 4 , , , cord-003926-ycdaw2vh 43 5 vaccination vaccination NN cord-003926-ycdaw2vh 43 6 during during IN cord-003926-ycdaw2vh 43 7 pregnancy pregnancy NN cord-003926-ycdaw2vh 43 8 is be VBZ cord-003926-ycdaw2vh 43 9 non non JJ cord-003926-ycdaw2vh 43 10 - - JJ cord-003926-ycdaw2vh 43 11 ideal ideal JJ cord-003926-ycdaw2vh 43 12 due due IN cord-003926-ycdaw2vh 43 13 to to IN cord-003926-ycdaw2vh 43 14 the the DT cord-003926-ycdaw2vh 43 15 time time NN cord-003926-ycdaw2vh 43 16 to to TO cord-003926-ycdaw2vh 43 17 generate generate VB cord-003926-ycdaw2vh 43 18 protective protective JJ cord-003926-ycdaw2vh 43 19 immunity immunity NN cord-003926-ycdaw2vh 43 20 and and CC cord-003926-ycdaw2vh 43 21 unknown unknown JJ cord-003926-ycdaw2vh 43 22 vaccine vaccine NN cord-003926-ycdaw2vh 43 23 safety safety NN cord-003926-ycdaw2vh 43 24 [ [ -LRB- cord-003926-ycdaw2vh 43 25 34 34 CD cord-003926-ycdaw2vh 43 26 ] ] -RRB- cord-003926-ycdaw2vh 43 27 . . . cord-003926-ycdaw2vh 44 1 The the DT cord-003926-ycdaw2vh 44 2 one one CD cord-003926-ycdaw2vh 44 3 unknown unknown JJ cord-003926-ycdaw2vh 44 4 aspect aspect NN cord-003926-ycdaw2vh 44 5 is be VBZ cord-003926-ycdaw2vh 44 6 whether whether IN cord-003926-ycdaw2vh 44 7 vaccination vaccination NN cord-003926-ycdaw2vh 44 8 of of IN cord-003926-ycdaw2vh 44 9 males male NNS cord-003926-ycdaw2vh 44 10 of of IN cord-003926-ycdaw2vh 44 11 any any DT cord-003926-ycdaw2vh 44 12 age age NN cord-003926-ycdaw2vh 44 13 may may MD cord-003926-ycdaw2vh 44 14 be be VB cord-003926-ycdaw2vh 44 15 beneficial beneficial JJ cord-003926-ycdaw2vh 44 16 to to TO cord-003926-ycdaw2vh 44 17 protect protect VB cord-003926-ycdaw2vh 44 18 against against IN cord-003926-ycdaw2vh 44 19 testicular testicular JJ cord-003926-ycdaw2vh 44 20 complications complication NNS cord-003926-ycdaw2vh 44 21 . . . cord-003926-ycdaw2vh 45 1 Calls call NNS cord-003926-ycdaw2vh 45 2 for for IN cord-003926-ycdaw2vh 45 3 generalized generalized JJ cord-003926-ycdaw2vh 45 4 vaccination vaccination NN cord-003926-ycdaw2vh 45 5 programs program NNS cord-003926-ycdaw2vh 45 6 have have VBP cord-003926-ycdaw2vh 45 7 , , , cord-003926-ycdaw2vh 45 8 however however RB cord-003926-ycdaw2vh 45 9 , , , cord-003926-ycdaw2vh 45 10 been be VBN cord-003926-ycdaw2vh 45 11 put put VBN cord-003926-ycdaw2vh 45 12 on on IN cord-003926-ycdaw2vh 45 13 hold hold NN cord-003926-ycdaw2vh 45 14 due due IN cord-003926-ycdaw2vh 45 15 to to IN cord-003926-ycdaw2vh 45 16 the the DT cord-003926-ycdaw2vh 45 17 decreasing decrease VBG cord-003926-ycdaw2vh 45 18 incidence incidence NN cord-003926-ycdaw2vh 45 19 of of IN cord-003926-ycdaw2vh 45 20 Zika Zika NNP cord-003926-ycdaw2vh 45 21 infection infection NN cord-003926-ycdaw2vh 45 22 rates rate NNS cord-003926-ycdaw2vh 45 23 , , , cord-003926-ycdaw2vh 45 24 as as IN cord-003926-ycdaw2vh 45 25 discussed discuss VBN cord-003926-ycdaw2vh 45 26 in in IN cord-003926-ycdaw2vh 45 27 the the DT cord-003926-ycdaw2vh 45 28 next next JJ cord-003926-ycdaw2vh 45 29 section section NN cord-003926-ycdaw2vh 45 30 . . . cord-003926-ycdaw2vh 46 1 In in IN cord-003926-ycdaw2vh 46 2 late late JJ cord-003926-ycdaw2vh 46 3 2015 2015 CD cord-003926-ycdaw2vh 46 4 and and CC cord-003926-ycdaw2vh 46 5 through through IN cord-003926-ycdaw2vh 46 6 mid-2016 mid-2016 NN cord-003926-ycdaw2vh 46 7 , , , cord-003926-ycdaw2vh 46 8 global global JJ cord-003926-ycdaw2vh 46 9 concern concern NN cord-003926-ycdaw2vh 46 10 for for IN cord-003926-ycdaw2vh 46 11 this this DT cord-003926-ycdaw2vh 46 12 spreading spread VBG cord-003926-ycdaw2vh 46 13 epidemic epidemic NN cord-003926-ycdaw2vh 46 14 was be VBD cord-003926-ycdaw2vh 46 15 increasing increase VBG cord-003926-ycdaw2vh 46 16 , , , cord-003926-ycdaw2vh 46 17 however however RB cord-003926-ycdaw2vh 46 18 , , , cord-003926-ycdaw2vh 46 19 the the DT cord-003926-ycdaw2vh 46 20 experience experience NN cord-003926-ycdaw2vh 46 21 in in IN cord-003926-ycdaw2vh 46 22 the the DT cord-003926-ycdaw2vh 46 23 two two CD cord-003926-ycdaw2vh 46 24 prior prior JJ cord-003926-ycdaw2vh 46 25 epidemics epidemic NNS cord-003926-ycdaw2vh 46 26 was be VBD cord-003926-ycdaw2vh 46 27 predictive predictive JJ cord-003926-ycdaw2vh 46 28 of of IN cord-003926-ycdaw2vh 46 29 the the DT cord-003926-ycdaw2vh 46 30 subsequent subsequent JJ cord-003926-ycdaw2vh 46 31 epidemiology epidemiology NN cord-003926-ycdaw2vh 46 32 in in IN cord-003926-ycdaw2vh 46 33 the the DT cord-003926-ycdaw2vh 46 34 Americas Americas NNPS cord-003926-ycdaw2vh 46 35 . . . cord-003926-ycdaw2vh 47 1 The the DT cord-003926-ycdaw2vh 47 2 Zika Zika NNP cord-003926-ycdaw2vh 47 3 virus virus NN cord-003926-ycdaw2vh 47 4 outbreaks outbreak NNS cord-003926-ycdaw2vh 47 5 in in IN cord-003926-ycdaw2vh 47 6 Yap Yap NNP cord-003926-ycdaw2vh 47 7 Island Island NNP cord-003926-ycdaw2vh 47 8 and and CC cord-003926-ycdaw2vh 47 9 French French NNP cord-003926-ycdaw2vh 47 10 Polynesia Polynesia NNP cord-003926-ycdaw2vh 47 11 were be VBD cord-003926-ycdaw2vh 47 12 characterized characterize VBN cord-003926-ycdaw2vh 47 13 by by IN cord-003926-ycdaw2vh 47 14 rapid rapid JJ cord-003926-ycdaw2vh 47 15 onset onset NN cord-003926-ycdaw2vh 47 16 and and CC cord-003926-ycdaw2vh 47 17 rapid rapid JJ cord-003926-ycdaw2vh 47 18 resolution resolution NN cord-003926-ycdaw2vh 47 19 over over IN cord-003926-ycdaw2vh 47 20 a a DT cord-003926-ycdaw2vh 47 21 span span NN cord-003926-ycdaw2vh 47 22 of of IN cord-003926-ycdaw2vh 47 23 3 3 CD cord-003926-ycdaw2vh 47 24 - - SYM cord-003926-ycdaw2vh 47 25 4 4 CD cord-003926-ycdaw2vh 47 26 months month NNS cord-003926-ycdaw2vh 47 27 [ [ -LRB- cord-003926-ycdaw2vh 47 28 3 3 CD cord-003926-ycdaw2vh 47 29 , , , cord-003926-ycdaw2vh 47 30 9 9 CD cord-003926-ycdaw2vh 47 31 ] ] -RRB- cord-003926-ycdaw2vh 47 32 . . . cord-003926-ycdaw2vh 48 1 The the DT cord-003926-ycdaw2vh 48 2 Zika Zika NNP cord-003926-ycdaw2vh 48 3 epidemic epidemic NN cord-003926-ycdaw2vh 48 4 in in IN cord-003926-ycdaw2vh 48 5 the the DT cord-003926-ycdaw2vh 48 6 Americas Americas NNPS cord-003926-ycdaw2vh 48 7 was be VBD cord-003926-ycdaw2vh 48 8 characterized characterize VBN cord-003926-ycdaw2vh 48 9 by by IN cord-003926-ycdaw2vh 48 10 a a DT cord-003926-ycdaw2vh 48 11 longer long JJR cord-003926-ycdaw2vh 48 12 time time NN cord-003926-ycdaw2vh 48 13 to to TO cord-003926-ycdaw2vh 48 14 reach reach VB cord-003926-ycdaw2vh 48 15 peak peak NN cord-003926-ycdaw2vh 48 16 incidence incidence NN cord-003926-ycdaw2vh 48 17 , , , cord-003926-ycdaw2vh 48 18 taking take VBG cord-003926-ycdaw2vh 48 19 approximately approximately RB cord-003926-ycdaw2vh 48 20 one one CD cord-003926-ycdaw2vh 48 21 year year NN cord-003926-ycdaw2vh 48 22 for for IN cord-003926-ycdaw2vh 48 23 Brazil Brazil NNP cord-003926-ycdaw2vh 48 24 [ [ -LRB- cord-003926-ycdaw2vh 48 25 35 35 CD cord-003926-ycdaw2vh 48 26 ] ] -RRB- cord-003926-ycdaw2vh 48 27 presumably presumably RB cord-003926-ycdaw2vh 48 28 related relate VBN cord-003926-ycdaw2vh 48 29 to to IN cord-003926-ycdaw2vh 48 30 the the DT cord-003926-ycdaw2vh 48 31 larger large JJR cord-003926-ycdaw2vh 48 32 and and CC cord-003926-ycdaw2vh 48 33 more more RBR cord-003926-ycdaw2vh 48 34 varied varied JJ cord-003926-ycdaw2vh 48 35 geography geography NN cord-003926-ycdaw2vh 48 36 , , , cord-003926-ycdaw2vh 48 37 with with IN cord-003926-ycdaw2vh 48 38 attack attack NN cord-003926-ycdaw2vh 48 39 rates rate NNS cord-003926-ycdaw2vh 48 40 decreasing decrease VBG cord-003926-ycdaw2vh 48 41 greater great JJR cord-003926-ycdaw2vh 48 42 than than IN cord-003926-ycdaw2vh 48 43 100-fold 100-fold CD cord-003926-ycdaw2vh 48 44 the the DT cord-003926-ycdaw2vh 48 45 next next JJ cord-003926-ycdaw2vh 48 46 year year NN cord-003926-ycdaw2vh 48 47 [ [ -LRB- cord-003926-ycdaw2vh 48 48 35 35 CD cord-003926-ycdaw2vh 48 49 ] ] -RRB- cord-003926-ycdaw2vh 48 50 . . . cord-003926-ycdaw2vh 49 1 Data datum NNS cord-003926-ycdaw2vh 49 2 published publish VBN cord-003926-ycdaw2vh 49 3 by by IN cord-003926-ycdaw2vh 49 4 the the DT cord-003926-ycdaw2vh 49 5 Pan Pan NNP cord-003926-ycdaw2vh 49 6 American American NNP cord-003926-ycdaw2vh 49 7 Health Health NNP cord-003926-ycdaw2vh 49 8 Organization Organization NNP cord-003926-ycdaw2vh 49 9 ( ( -LRB- cord-003926-ycdaw2vh 49 10 PAHO PAHO NNP cord-003926-ycdaw2vh 49 11 ) ) -RRB- cord-003926-ycdaw2vh 49 12 found find VBD cord-003926-ycdaw2vh 49 13 similar similar JJ cord-003926-ycdaw2vh 49 14 patterns pattern NNS cord-003926-ycdaw2vh 49 15 through through IN cord-003926-ycdaw2vh 49 16 South South NNP cord-003926-ycdaw2vh 49 17 and and CC cord-003926-ycdaw2vh 49 18 Central Central NNP cord-003926-ycdaw2vh 49 19 America America NNP cord-003926-ycdaw2vh 49 20 ( ( -LRB- cord-003926-ycdaw2vh 49 21 https://www.paho.org/ https://www.paho.org/ ADD cord-003926-ycdaw2vh 49 22 ) ) -RRB- cord-003926-ycdaw2vh 49 23 . . . cord-003926-ycdaw2vh 50 1 The the DT cord-003926-ycdaw2vh 50 2 almost almost RB cord-003926-ycdaw2vh 50 3 complete complete JJ cord-003926-ycdaw2vh 50 4 disappearance disappearance NN cord-003926-ycdaw2vh 50 5 of of IN cord-003926-ycdaw2vh 50 6 Zika Zika NNP cord-003926-ycdaw2vh 50 7 has have VBZ cord-003926-ycdaw2vh 50 8 created create VBN cord-003926-ycdaw2vh 50 9 significant significant JJ cord-003926-ycdaw2vh 50 10 barriers barrier NNS cord-003926-ycdaw2vh 50 11 to to IN cord-003926-ycdaw2vh 50 12 ongoing ongoing JJ cord-003926-ycdaw2vh 50 13 vaccine vaccine NN cord-003926-ycdaw2vh 50 14 studies study NNS cord-003926-ycdaw2vh 50 15 as as IN cord-003926-ycdaw2vh 50 16 attack attack NN cord-003926-ycdaw2vh 50 17 rates rate NNS cord-003926-ycdaw2vh 50 18 have have VBP cord-003926-ycdaw2vh 50 19 fallen fall VBN cord-003926-ycdaw2vh 50 20 below below IN cord-003926-ycdaw2vh 50 21 those those DT cord-003926-ycdaw2vh 50 22 need need VBP cord-003926-ycdaw2vh 50 23 to to TO cord-003926-ycdaw2vh 50 24 meet meet VB cord-003926-ycdaw2vh 50 25 reasonable reasonable JJ cord-003926-ycdaw2vh 50 26 sample sample NN cord-003926-ycdaw2vh 50 27 sizes size NNS cord-003926-ycdaw2vh 50 28 [ [ -LRB- cord-003926-ycdaw2vh 50 29 6 6 CD cord-003926-ycdaw2vh 50 30 ] ] -RRB- cord-003926-ycdaw2vh 50 31 . . . cord-003926-ycdaw2vh 51 1 The the DT cord-003926-ycdaw2vh 51 2 WHO who WP cord-003926-ycdaw2vh 51 3 removed remove VBD cord-003926-ycdaw2vh 51 4 the the DT cord-003926-ycdaw2vh 51 5 designation designation NN cord-003926-ycdaw2vh 51 6 of of IN cord-003926-ycdaw2vh 51 7 Zika Zika NNP cord-003926-ycdaw2vh 51 8 a a DT cord-003926-ycdaw2vh 51 9 virus virus NN cord-003926-ycdaw2vh 51 10 of of IN cord-003926-ycdaw2vh 51 11 global global JJ cord-003926-ycdaw2vh 51 12 concern concern NN cord-003926-ycdaw2vh 51 13 in in IN cord-003926-ycdaw2vh 51 14 2018 2018 CD cord-003926-ycdaw2vh 51 15 as as IN cord-003926-ycdaw2vh 51 16 case case NN cord-003926-ycdaw2vh 51 17 rates rate NNS cord-003926-ycdaw2vh 51 18 have have VBP cord-003926-ycdaw2vh 51 19 fallen fall VBN cord-003926-ycdaw2vh 51 20 . . . cord-003926-ycdaw2vh 52 1 In in IN cord-003926-ycdaw2vh 52 2 March March NNP cord-003926-ycdaw2vh 52 3 2018 2018 CD cord-003926-ycdaw2vh 52 4 , , , cord-003926-ycdaw2vh 52 5 the the DT cord-003926-ycdaw2vh 52 6 WHO WHO NNP cord-003926-ycdaw2vh 52 7 and and CC cord-003926-ycdaw2vh 52 8 the the DT cord-003926-ycdaw2vh 52 9 National National NNP cord-003926-ycdaw2vh 52 10 Institutes Institutes NNPS cord-003926-ycdaw2vh 52 11 of of IN cord-003926-ycdaw2vh 52 12 Allergy Allergy NNP cord-003926-ycdaw2vh 52 13 and and CC cord-003926-ycdaw2vh 52 14 Infectious Infectious NNP cord-003926-ycdaw2vh 52 15 Diseases Diseases NNPS cord-003926-ycdaw2vh 52 16 ( ( -LRB- cord-003926-ycdaw2vh 52 17 NIAID NIAID NNP cord-003926-ycdaw2vh 52 18 ) ) -RRB- cord-003926-ycdaw2vh 52 19 convened convene VBD cord-003926-ycdaw2vh 52 20 a a DT cord-003926-ycdaw2vh 52 21 meeting meeting NN cord-003926-ycdaw2vh 52 22 of of IN cord-003926-ycdaw2vh 52 23 academics academic NNS cord-003926-ycdaw2vh 52 24 , , , cord-003926-ycdaw2vh 52 25 representatives representative NNS cord-003926-ycdaw2vh 52 26 from from IN cord-003926-ycdaw2vh 52 27 industry industry NN cord-003926-ycdaw2vh 52 28 , , , cord-003926-ycdaw2vh 52 29 and and CC cord-003926-ycdaw2vh 52 30 regulators regulator NNS cord-003926-ycdaw2vh 52 31 to to TO cord-003926-ycdaw2vh 52 32 discuss discuss VB cord-003926-ycdaw2vh 52 33 the the DT cord-003926-ycdaw2vh 52 34 approach approach NN cord-003926-ycdaw2vh 52 35 to to IN cord-003926-ycdaw2vh 52 36 Zika Zika NNP cord-003926-ycdaw2vh 52 37 virus virus NN cord-003926-ycdaw2vh 52 38 vaccine vaccine NN cord-003926-ycdaw2vh 52 39 development development NN cord-003926-ycdaw2vh 52 40 in in IN cord-003926-ycdaw2vh 52 41 an an DT cord-003926-ycdaw2vh 52 42 era era NN cord-003926-ycdaw2vh 52 43 of of IN cord-003926-ycdaw2vh 52 44 waning wane VBG cord-003926-ycdaw2vh 52 45 incidence incidence NN cord-003926-ycdaw2vh 52 46 [ [ -LRB- cord-003926-ycdaw2vh 52 47 7 7 CD cord-003926-ycdaw2vh 52 48 ] ] -RRB- cord-003926-ycdaw2vh 52 49 . . . cord-003926-ycdaw2vh 53 1 Although although IN cord-003926-ycdaw2vh 53 2 Zika Zika NNP cord-003926-ycdaw2vh 53 3 virus virus NN cord-003926-ycdaw2vh 53 4 remains remain VBZ cord-003926-ycdaw2vh 53 5 endemic endemic JJ cord-003926-ycdaw2vh 53 6 in in IN cord-003926-ycdaw2vh 53 7 Asia Asia NNP cord-003926-ycdaw2vh 53 8 , , , cord-003926-ycdaw2vh 53 9 Africa Africa NNP cord-003926-ycdaw2vh 53 10 , , , cord-003926-ycdaw2vh 53 11 and and CC cord-003926-ycdaw2vh 53 12 Central Central NNP cord-003926-ycdaw2vh 53 13 and and CC cord-003926-ycdaw2vh 53 14 South South NNP cord-003926-ycdaw2vh 53 15 America America NNP cord-003926-ycdaw2vh 53 16 , , , cord-003926-ycdaw2vh 53 17 current current JJ cord-003926-ycdaw2vh 53 18 transmission transmission NN cord-003926-ycdaw2vh 53 19 rates rate NNS cord-003926-ycdaw2vh 53 20 , , , cord-003926-ycdaw2vh 53 21 coupled couple VBN cord-003926-ycdaw2vh 53 22 with with IN cord-003926-ycdaw2vh 53 23 high high JJ cord-003926-ycdaw2vh 53 24 background background NN cord-003926-ycdaw2vh 53 25 herd herd NN cord-003926-ycdaw2vh 53 26 immunity immunity NN cord-003926-ycdaw2vh 53 27 , , , cord-003926-ycdaw2vh 53 28 would would MD cord-003926-ycdaw2vh 53 29 require require VB cord-003926-ycdaw2vh 53 30 an an DT cord-003926-ycdaw2vh 53 31 extremely extremely RB cord-003926-ycdaw2vh 53 32 large large JJ cord-003926-ycdaw2vh 53 33 and and CC cord-003926-ycdaw2vh 53 34 logistically logistically RB cord-003926-ycdaw2vh 53 35 difficult difficult JJ cord-003926-ycdaw2vh 53 36 study study NN cord-003926-ycdaw2vh 53 37 . . . cord-003926-ycdaw2vh 54 1 As as IN cord-003926-ycdaw2vh 54 2 population population NN cord-003926-ycdaw2vh 54 3 immunity immunity NN cord-003926-ycdaw2vh 54 4 wanes wane VBZ cord-003926-ycdaw2vh 54 5 , , , cord-003926-ycdaw2vh 54 6 future future JJ cord-003926-ycdaw2vh 54 7 outbreaks outbreak NNS cord-003926-ycdaw2vh 54 8 are be VBP cord-003926-ycdaw2vh 54 9 likely likely JJ cord-003926-ycdaw2vh 54 10 . . . cord-003926-ycdaw2vh 55 1 The the DT cord-003926-ycdaw2vh 55 2 ability ability NN cord-003926-ycdaw2vh 55 3 to to TO cord-003926-ycdaw2vh 55 4 conduct conduct VB cord-003926-ycdaw2vh 55 5 a a DT cord-003926-ycdaw2vh 55 6 meaningful meaningful JJ cord-003926-ycdaw2vh 55 7 future future JJ cord-003926-ycdaw2vh 55 8 clinical clinical JJ cord-003926-ycdaw2vh 55 9 trial trial NN cord-003926-ycdaw2vh 55 10 may may MD cord-003926-ycdaw2vh 55 11 be be VB cord-003926-ycdaw2vh 55 12 dependent dependent JJ cord-003926-ycdaw2vh 55 13 upon upon IN cord-003926-ycdaw2vh 55 14 having have VBG cord-003926-ycdaw2vh 55 15 pre pre JJ cord-003926-ycdaw2vh 55 16 - - JJ cord-003926-ycdaw2vh 55 17 existing existing JJ cord-003926-ycdaw2vh 55 18 site site NN cord-003926-ycdaw2vh 55 19 and and CC cord-003926-ycdaw2vh 55 20 regulatory regulatory JJ cord-003926-ycdaw2vh 55 21 approvals approval NNS cord-003926-ycdaw2vh 55 22 with with IN cord-003926-ycdaw2vh 55 23 an an DT cord-003926-ycdaw2vh 55 24 established establish VBN cord-003926-ycdaw2vh 55 25 vaccine vaccine NN cord-003926-ycdaw2vh 55 26 network network NN cord-003926-ycdaw2vh 55 27 to to TO cord-003926-ycdaw2vh 55 28 enable enable VB cord-003926-ycdaw2vh 55 29 rapid rapid JJ cord-003926-ycdaw2vh 55 30 response response NN cord-003926-ycdaw2vh 55 31 to to IN cord-003926-ycdaw2vh 55 32 new new JJ cord-003926-ycdaw2vh 55 33 reports report NNS cord-003926-ycdaw2vh 55 34 suggesting suggest VBG cord-003926-ycdaw2vh 55 35 increased increase VBN cord-003926-ycdaw2vh 55 36 disease disease NN cord-003926-ycdaw2vh 55 37 activity activity NN cord-003926-ycdaw2vh 55 38 . . . cord-003926-ycdaw2vh 56 1 Vaccine vaccine NN cord-003926-ycdaw2vh 56 2 development development NN cord-003926-ycdaw2vh 56 3 against against IN cord-003926-ycdaw2vh 56 4 the the DT cord-003926-ycdaw2vh 56 5 Zika Zika NNP cord-003926-ycdaw2vh 56 6 virus virus NN cord-003926-ycdaw2vh 56 7 began begin VBD cord-003926-ycdaw2vh 56 8 in in IN cord-003926-ycdaw2vh 56 9 earnest earnest JJ cord-003926-ycdaw2vh 56 10 in in IN cord-003926-ycdaw2vh 56 11 late late JJ cord-003926-ycdaw2vh 56 12 2015 2015 CD cord-003926-ycdaw2vh 56 13 following follow VBG cord-003926-ycdaw2vh 56 14 the the DT cord-003926-ycdaw2vh 56 15 reports report NNS cord-003926-ycdaw2vh 56 16 of of IN cord-003926-ycdaw2vh 56 17 microcephaly microcephaly NNS cord-003926-ycdaw2vh 56 18 in in IN cord-003926-ycdaw2vh 56 19 fetuses fetus NNS cord-003926-ycdaw2vh 56 20 and and CC cord-003926-ycdaw2vh 56 21 infants infant NNS cord-003926-ycdaw2vh 56 22 in in IN cord-003926-ycdaw2vh 56 23 Brazil Brazil NNP cord-003926-ycdaw2vh 56 24 . . . cord-003926-ycdaw2vh 57 1 Of of IN cord-003926-ycdaw2vh 57 2 note note NN cord-003926-ycdaw2vh 57 3 , , , cord-003926-ycdaw2vh 57 4 the the DT cord-003926-ycdaw2vh 57 5 first first JJ cord-003926-ycdaw2vh 57 6 demonstration demonstration NN cord-003926-ycdaw2vh 57 7 of of IN cord-003926-ycdaw2vh 57 8 immunoprotection immunoprotection NN cord-003926-ycdaw2vh 57 9 was be VBD cord-003926-ycdaw2vh 57 10 as as IN cord-003926-ycdaw2vh 57 11 part part NN cord-003926-ycdaw2vh 57 12 of of IN cord-003926-ycdaw2vh 57 13 a a DT cord-003926-ycdaw2vh 57 14 1953 1953 CD cord-003926-ycdaw2vh 57 15 study study NN cord-003926-ycdaw2vh 57 16 to to TO cord-003926-ycdaw2vh 57 17 define define VB cord-003926-ycdaw2vh 57 18 the the DT cord-003926-ycdaw2vh 57 19 ultrastructural ultrastructural JJ cord-003926-ycdaw2vh 57 20 characteristics characteristic NNS cord-003926-ycdaw2vh 57 21 of of IN cord-003926-ycdaw2vh 57 22 Zika Zika NNP cord-003926-ycdaw2vh 57 23 virus virus NN cord-003926-ycdaw2vh 57 24 , , , cord-003926-ycdaw2vh 57 25 that that WDT cord-003926-ycdaw2vh 57 26 found find VBD cord-003926-ycdaw2vh 57 27 intramuscular intramuscular JJ cord-003926-ycdaw2vh 57 28 vaccination vaccination NN cord-003926-ycdaw2vh 57 29 of of IN cord-003926-ycdaw2vh 57 30 mice mouse NNS cord-003926-ycdaw2vh 57 31 with with IN cord-003926-ycdaw2vh 57 32 infectious infectious JJ cord-003926-ycdaw2vh 57 33 viral viral JJ cord-003926-ycdaw2vh 57 34 filtrates filtrate NNS cord-003926-ycdaw2vh 57 35 protected protect VBN cord-003926-ycdaw2vh 57 36 against against IN cord-003926-ycdaw2vh 57 37 cerebral cerebral JJ cord-003926-ycdaw2vh 57 38 infection infection NN cord-003926-ycdaw2vh 57 39 [ [ -LRB- cord-003926-ycdaw2vh 57 40 36 36 CD cord-003926-ycdaw2vh 57 41 ] ] -RRB- cord-003926-ycdaw2vh 57 42 . . . cord-003926-ycdaw2vh 58 1 Poland Poland NNP cord-003926-ycdaw2vh 58 2 et et NNP cord-003926-ycdaw2vh 58 3 al al NNP cord-003926-ycdaw2vh 58 4 . . . cord-003926-ycdaw2vh 59 1 provide provide VB cord-003926-ycdaw2vh 59 2 a a DT cord-003926-ycdaw2vh 59 3 comprehensive comprehensive JJ cord-003926-ycdaw2vh 59 4 listing listing NN cord-003926-ycdaw2vh 59 5 of of IN cord-003926-ycdaw2vh 59 6 almost almost RB cord-003926-ycdaw2vh 59 7 40 40 CD cord-003926-ycdaw2vh 59 8 Zika Zika NNP cord-003926-ycdaw2vh 59 9 virus virus NN cord-003926-ycdaw2vh 59 10 vaccines vaccine NNS cord-003926-ycdaw2vh 59 11 in in IN cord-003926-ycdaw2vh 59 12 development development NN cord-003926-ycdaw2vh 59 13 as as IN cord-003926-ycdaw2vh 59 14 of of IN cord-003926-ycdaw2vh 59 15 2017 2017 CD cord-003926-ycdaw2vh 59 16 [ [ -LRB- cord-003926-ycdaw2vh 59 17 37 37 CD cord-003926-ycdaw2vh 59 18 ] ] -RRB- cord-003926-ycdaw2vh 59 19 . . . cord-003926-ycdaw2vh 60 1 Diamond Diamond NNP cord-003926-ycdaw2vh 60 2 et et NNP cord-003926-ycdaw2vh 60 3 al al NNP cord-003926-ycdaw2vh 60 4 . . . cord-003926-ycdaw2vh 61 1 discuss discuss VB cord-003926-ycdaw2vh 61 2 potential potential JJ cord-003926-ycdaw2vh 61 3 immunoreactive immunoreactive JJ cord-003926-ycdaw2vh 61 4 epitopes epitope NNS cord-003926-ycdaw2vh 61 5 on on IN cord-003926-ycdaw2vh 61 6 the the DT cord-003926-ycdaw2vh 61 7 Zika Zika NNP cord-003926-ycdaw2vh 61 8 envelope envelope NN cord-003926-ycdaw2vh 61 9 and and CC cord-003926-ycdaw2vh 61 10 provide provide VB cord-003926-ycdaw2vh 61 11 further further JJ cord-003926-ycdaw2vh 61 12 information information NN cord-003926-ycdaw2vh 61 13 on on IN cord-003926-ycdaw2vh 61 14 those those DT cord-003926-ycdaw2vh 61 15 vaccines vaccine NNS cord-003926-ycdaw2vh 61 16 that that WDT cord-003926-ycdaw2vh 61 17 progressed progress VBD cord-003926-ycdaw2vh 61 18 into into IN cord-003926-ycdaw2vh 61 19 clinical clinical JJ cord-003926-ycdaw2vh 61 20 trials trial NNS cord-003926-ycdaw2vh 61 21 [ [ -LRB- cord-003926-ycdaw2vh 61 22 38 38 CD cord-003926-ycdaw2vh 61 23 ] ] -RRB- cord-003926-ycdaw2vh 61 24 . . . cord-003926-ycdaw2vh 62 1 The the DT cord-003926-ycdaw2vh 62 2 large large JJ cord-003926-ycdaw2vh 62 3 number number NN cord-003926-ycdaw2vh 62 4 of of IN cord-003926-ycdaw2vh 62 5 delivery delivery NN cord-003926-ycdaw2vh 62 6 platforms platform NNS cord-003926-ycdaw2vh 62 7 include include VBP cord-003926-ycdaw2vh 62 8 live live VBP cord-003926-ycdaw2vh 62 9 attenuated attenuated JJ cord-003926-ycdaw2vh 62 10 and and CC cord-003926-ycdaw2vh 62 11 inactivated inactivate VBN cord-003926-ycdaw2vh 62 12 whole whole JJ cord-003926-ycdaw2vh 62 13 - - HYPH cord-003926-ycdaw2vh 62 14 viruses virus NNS cord-003926-ycdaw2vh 62 15 ; ; : cord-003926-ycdaw2vh 62 16 viral viral RB cord-003926-ycdaw2vh 62 17 - - HYPH cord-003926-ycdaw2vh 62 18 vectored vectore VBN cord-003926-ycdaw2vh 62 19 vaccines vaccine NNS cord-003926-ycdaw2vh 62 20 utilizing utilize VBG cord-003926-ycdaw2vh 62 21 adeno adeno NN cord-003926-ycdaw2vh 62 22 - - HYPH cord-003926-ycdaw2vh 62 23 associated associate VBN cord-003926-ycdaw2vh 62 24 virus virus NN cord-003926-ycdaw2vh 62 25 , , , cord-003926-ycdaw2vh 62 26 vesicular vesicular JJ cord-003926-ycdaw2vh 62 27 stomatitis stomatitis NN cord-003926-ycdaw2vh 62 28 virus virus NN cord-003926-ycdaw2vh 62 29 , , , cord-003926-ycdaw2vh 62 30 measles measles NN cord-003926-ycdaw2vh 62 31 virus virus NN cord-003926-ycdaw2vh 62 32 , , , cord-003926-ycdaw2vh 62 33 and and CC cord-003926-ycdaw2vh 62 34 dengue dengue NN cord-003926-ycdaw2vh 62 35 or or CC cord-003926-ycdaw2vh 62 36 Yellow Yellow NNP cord-003926-ycdaw2vh 62 37 Fever Fever NNP cord-003926-ycdaw2vh 62 38 chimeric chimeric JJ cord-003926-ycdaw2vh 62 39 vaccines vaccine NNS cord-003926-ycdaw2vh 62 40 ; ; : cord-003926-ycdaw2vh 62 41 DNA DNA NNP cord-003926-ycdaw2vh 62 42 and and CC cord-003926-ycdaw2vh 62 43 mRNA mrna NN cord-003926-ycdaw2vh 62 44 vaccines vaccine NNS cord-003926-ycdaw2vh 62 45 ; ; : cord-003926-ycdaw2vh 62 46 and and CC cord-003926-ycdaw2vh 62 47 peptide peptide NN cord-003926-ycdaw2vh 62 48 and and CC cord-003926-ycdaw2vh 62 49 protein protein NN cord-003926-ycdaw2vh 62 50 subunit subunit NN cord-003926-ycdaw2vh 62 51 vaccines vaccine NNS cord-003926-ycdaw2vh 62 52 . . . cord-003926-ycdaw2vh 63 1 Most Most JJS cord-003926-ycdaw2vh 63 2 have have VBP cord-003926-ycdaw2vh 63 3 been be VBN cord-003926-ycdaw2vh 63 4 assessed assess VBN cord-003926-ycdaw2vh 63 5 in in IN cord-003926-ycdaw2vh 63 6 animal animal NN cord-003926-ycdaw2vh 63 7 models model NNS cord-003926-ycdaw2vh 63 8 utilizing utilize VBG cord-003926-ycdaw2vh 63 9 non non JJ cord-003926-ycdaw2vh 63 10 - - JJ cord-003926-ycdaw2vh 63 11 human human JJ cord-003926-ycdaw2vh 63 12 primates primate NNS cord-003926-ycdaw2vh 63 13 and/or and/or CC cord-003926-ycdaw2vh 63 14 lethal lethal JJ cord-003926-ycdaw2vh 63 15 challenge challenge NN cord-003926-ycdaw2vh 63 16 experiments experiment NNS cord-003926-ycdaw2vh 63 17 involving involve VBG cord-003926-ycdaw2vh 63 18 immunosuppressed immunosuppressed JJ cord-003926-ycdaw2vh 63 19 mice mouse NNS cord-003926-ycdaw2vh 63 20 [ [ -LRB- cord-003926-ycdaw2vh 63 21 37 37 CD cord-003926-ycdaw2vh 63 22 ] ] -RRB- cord-003926-ycdaw2vh 63 23 . . . cord-003926-ycdaw2vh 64 1 As as IN cord-003926-ycdaw2vh 64 2 of of IN cord-003926-ycdaw2vh 64 3 2017 2017 CD cord-003926-ycdaw2vh 64 4 , , , cord-003926-ycdaw2vh 64 5 six six CD cord-003926-ycdaw2vh 64 6 vaccines vaccine NNS cord-003926-ycdaw2vh 64 7 had have VBD cord-003926-ycdaw2vh 64 8 advanced advance VBN cord-003926-ycdaw2vh 64 9 to to IN cord-003926-ycdaw2vh 64 10 Phase phase NN cord-003926-ycdaw2vh 65 1 I -PRON- PRP cord-003926-ycdaw2vh 65 2 studies study VBZ cord-003926-ycdaw2vh 65 3 [ [ -LRB- cord-003926-ycdaw2vh 65 4 37 37 CD cord-003926-ycdaw2vh 65 5 , , , cord-003926-ycdaw2vh 65 6 39 39 CD cord-003926-ycdaw2vh 65 7 , , , cord-003926-ycdaw2vh 65 8 40 40 CD cord-003926-ycdaw2vh 65 9 ] ] -RRB- cord-003926-ycdaw2vh 65 10 . . . cord-003926-ycdaw2vh 66 1 Since since IN cord-003926-ycdaw2vh 66 2 that that DT cord-003926-ycdaw2vh 66 3 time time NN cord-003926-ycdaw2vh 66 4 , , , cord-003926-ycdaw2vh 66 5 two two CD cord-003926-ycdaw2vh 66 6 additional additional JJ cord-003926-ycdaw2vh 66 7 vaccines vaccine NNS cord-003926-ycdaw2vh 66 8 have have VBP cord-003926-ycdaw2vh 66 9 entered enter VBN cord-003926-ycdaw2vh 66 10 into into IN cord-003926-ycdaw2vh 66 11 clinical clinical JJ cord-003926-ycdaw2vh 66 12 trials trial NNS cord-003926-ycdaw2vh 66 13 ( ( -LRB- cord-003926-ycdaw2vh 66 14 Table table NN cord-003926-ycdaw2vh 66 15 1 1 CD cord-003926-ycdaw2vh 66 16 ) ) -RRB- cord-003926-ycdaw2vh 66 17 . . . cord-003926-ycdaw2vh 67 1 A a DT cord-003926-ycdaw2vh 67 2 total total NN cord-003926-ycdaw2vh 67 3 of of IN cord-003926-ycdaw2vh 67 4 three three CD cord-003926-ycdaw2vh 67 5 DNA dna NN cord-003926-ycdaw2vh 67 6 vaccines vaccine NNS cord-003926-ycdaw2vh 67 7 have have VBP cord-003926-ycdaw2vh 67 8 entered enter VBN cord-003926-ycdaw2vh 67 9 into into IN cord-003926-ycdaw2vh 67 10 human human JJ cord-003926-ycdaw2vh 67 11 testing testing NN cord-003926-ycdaw2vh 67 12 [ [ -LRB- cord-003926-ycdaw2vh 67 13 41 41 CD cord-003926-ycdaw2vh 67 14 , , , cord-003926-ycdaw2vh 67 15 42 42 CD cord-003926-ycdaw2vh 67 16 ] ] -RRB- cord-003926-ycdaw2vh 67 17 , , , cord-003926-ycdaw2vh 67 18 including include VBG cord-003926-ycdaw2vh 67 19 one one NN cord-003926-ycdaw2vh 67 20 that that WDT cord-003926-ycdaw2vh 67 21 has have VBZ cord-003926-ycdaw2vh 67 22 advanced advance VBN cord-003926-ycdaw2vh 67 23 to to IN cord-003926-ycdaw2vh 67 24 Phase Phase NNP cord-003926-ycdaw2vh 67 25 II II NNP cord-003926-ycdaw2vh 67 26 ( ( -LRB- cord-003926-ycdaw2vh 67 27 Table table NN cord-003926-ycdaw2vh 67 28 1 1 CD cord-003926-ycdaw2vh 67 29 ) ) -RRB- cord-003926-ycdaw2vh 67 30 . . . cord-003926-ycdaw2vh 68 1 GLS-5700 GLS-5700 NNP cord-003926-ycdaw2vh 68 2 , , , cord-003926-ycdaw2vh 68 3 a a DT cord-003926-ycdaw2vh 68 4 DNA dna NN cord-003926-ycdaw2vh 68 5 vaccine vaccine NN cord-003926-ycdaw2vh 68 6 encoding encoding NN cord-003926-ycdaw2vh 68 7 for for IN cord-003926-ycdaw2vh 68 8 the the DT cord-003926-ycdaw2vh 68 9 Zika Zika NNP cord-003926-ycdaw2vh 68 10 virus virus NN cord-003926-ycdaw2vh 68 11 prME prME VBZ cord-003926-ycdaw2vh 68 12 genes gene NNS cord-003926-ycdaw2vh 68 13 designed design VBN cord-003926-ycdaw2vh 68 14 as as IN cord-003926-ycdaw2vh 68 15 a a DT cord-003926-ycdaw2vh 68 16 consensus consensus NN cord-003926-ycdaw2vh 68 17 based base VBN cord-003926-ycdaw2vh 68 18 on on IN cord-003926-ycdaw2vh 68 19 available available JJ cord-003926-ycdaw2vh 68 20 Zika Zika NNP cord-003926-ycdaw2vh 68 21 virus virus NN cord-003926-ycdaw2vh 68 22 sequences sequence NNS cord-003926-ycdaw2vh 68 23 through through IN cord-003926-ycdaw2vh 68 24 December December NNP cord-003926-ycdaw2vh 68 25 2015 2015 CD cord-003926-ycdaw2vh 68 26 [ [ -LRB- cord-003926-ycdaw2vh 68 27 43 43 CD cord-003926-ycdaw2vh 68 28 ] ] -RRB- cord-003926-ycdaw2vh 68 29 , , , cord-003926-ycdaw2vh 68 30 was be VBD cord-003926-ycdaw2vh 68 31 the the DT cord-003926-ycdaw2vh 68 32 first first JJ cord-003926-ycdaw2vh 68 33 to to TO cord-003926-ycdaw2vh 68 34 enter enter VB cord-003926-ycdaw2vh 68 35 into into IN cord-003926-ycdaw2vh 68 36 clinical clinical JJ cord-003926-ycdaw2vh 68 37 trials trial NNS cord-003926-ycdaw2vh 68 38 . . . cord-003926-ycdaw2vh 69 1 In in IN cord-003926-ycdaw2vh 69 2 pre pre JJ cord-003926-ycdaw2vh 69 3 - - JJ cord-003926-ycdaw2vh 69 4 clinical clinical JJ cord-003926-ycdaw2vh 69 5 studies study NNS cord-003926-ycdaw2vh 69 6 , , , cord-003926-ycdaw2vh 69 7 vaccinated vaccinate VBD cord-003926-ycdaw2vh 69 8 mice mouse NNS cord-003926-ycdaw2vh 69 9 and and CC cord-003926-ycdaw2vh 69 10 non non JJ cord-003926-ycdaw2vh 69 11 - - JJ cord-003926-ycdaw2vh 69 12 human human JJ cord-003926-ycdaw2vh 69 13 primates primate NNS cord-003926-ycdaw2vh 69 14 were be VBD cord-003926-ycdaw2vh 69 15 shown show VBN cord-003926-ycdaw2vh 69 16 to to TO cord-003926-ycdaw2vh 69 17 develop develop VB cord-003926-ycdaw2vh 69 18 B b NN cord-003926-ycdaw2vh 69 19 and and CC cord-003926-ycdaw2vh 69 20 T t NN cord-003926-ycdaw2vh 69 21 - - HYPH cord-003926-ycdaw2vh 69 22 cell cell NN cord-003926-ycdaw2vh 69 23 immune immune JJ cord-003926-ycdaw2vh 69 24 responses response NNS cord-003926-ycdaw2vh 69 25 against against IN cord-003926-ycdaw2vh 69 26 the the DT cord-003926-ycdaw2vh 69 27 Zika Zika NNP cord-003926-ycdaw2vh 69 28 virus virus NN cord-003926-ycdaw2vh 69 29 envelope envelope NN cord-003926-ycdaw2vh 69 30 and and CC cord-003926-ycdaw2vh 69 31 protected protect VBN cord-003926-ycdaw2vh 69 32 against against IN cord-003926-ycdaw2vh 69 33 development development NN cord-003926-ycdaw2vh 69 34 of of IN cord-003926-ycdaw2vh 69 35 neurologic neurologic JJ cord-003926-ycdaw2vh 69 36 disease disease NN cord-003926-ycdaw2vh 69 37 and and CC cord-003926-ycdaw2vh 69 38 death death NN cord-003926-ycdaw2vh 69 39 in in IN cord-003926-ycdaw2vh 69 40 immunosuppressed immunosuppressed JJ cord-003926-ycdaw2vh 69 41 , , , cord-003926-ycdaw2vh 69 42 interferon interferon NN cord-003926-ycdaw2vh 69 43 α α NN cord-003926-ycdaw2vh 69 44 , , , cord-003926-ycdaw2vh 69 45 β β NN cord-003926-ycdaw2vh 69 46 receptor receptor NN cord-003926-ycdaw2vh 69 47 deficient deficient JJ cord-003926-ycdaw2vh 69 48 ( ( -LRB- cord-003926-ycdaw2vh 69 49 IFNAR IFNAR NNP cord-003926-ycdaw2vh 69 50 ) ) -RRB- cord-003926-ycdaw2vh 69 51 mice mouse NNS cord-003926-ycdaw2vh 69 52 [ [ -LRB- cord-003926-ycdaw2vh 69 53 43 43 CD cord-003926-ycdaw2vh 69 54 ] ] -RRB- cord-003926-ycdaw2vh 69 55 . . . cord-003926-ycdaw2vh 70 1 Moreover moreover RB cord-003926-ycdaw2vh 70 2 , , , cord-003926-ycdaw2vh 70 3 histologic histologic JJ cord-003926-ycdaw2vh 70 4 sections section NNS cord-003926-ycdaw2vh 70 5 of of IN cord-003926-ycdaw2vh 70 6 brain brain NN cord-003926-ycdaw2vh 70 7 tissue tissue NN cord-003926-ycdaw2vh 70 8 showed show VBD cord-003926-ycdaw2vh 70 9 that that IN cord-003926-ycdaw2vh 70 10 vaccinated vaccinate VBN cord-003926-ycdaw2vh 70 11 mice mouse NNS cord-003926-ycdaw2vh 70 12 were be VBD cord-003926-ycdaw2vh 70 13 without without IN cord-003926-ycdaw2vh 70 14 inflammatory inflammatory JJ cord-003926-ycdaw2vh 70 15 infiltrates infiltrate NNS cord-003926-ycdaw2vh 70 16 evident evident JJ cord-003926-ycdaw2vh 70 17 in in IN cord-003926-ycdaw2vh 70 18 non non JJ cord-003926-ycdaw2vh 70 19 - - JJ cord-003926-ycdaw2vh 70 20 immunized immunized JJ cord-003926-ycdaw2vh 70 21 mice mouse NNS cord-003926-ycdaw2vh 70 22 [ [ -LRB- cord-003926-ycdaw2vh 70 23 43 43 CD cord-003926-ycdaw2vh 70 24 ] ] -RRB- cord-003926-ycdaw2vh 70 25 . . . cord-003926-ycdaw2vh 71 1 Subsequent subsequent JJ cord-003926-ycdaw2vh 71 2 studies study NNS cord-003926-ycdaw2vh 71 3 showed show VBD cord-003926-ycdaw2vh 71 4 that that IN cord-003926-ycdaw2vh 71 5 the the DT cord-003926-ycdaw2vh 71 6 vaccine vaccine NN cord-003926-ycdaw2vh 71 7 protected protect VBN cord-003926-ycdaw2vh 71 8 against against IN cord-003926-ycdaw2vh 71 9 testicular testicular JJ cord-003926-ycdaw2vh 71 10 damage damage NN cord-003926-ycdaw2vh 71 11 , , , cord-003926-ycdaw2vh 71 12 testicular testicular JJ cord-003926-ycdaw2vh 71 13 atrophy atrophy NN cord-003926-ycdaw2vh 71 14 , , , cord-003926-ycdaw2vh 71 15 spermatozoal spermatozoal NN cord-003926-ycdaw2vh 71 16 damage damage NN cord-003926-ycdaw2vh 71 17 , , , cord-003926-ycdaw2vh 71 18 and and CC cord-003926-ycdaw2vh 71 19 infertility infertility NN cord-003926-ycdaw2vh 71 20 in in IN cord-003926-ycdaw2vh 71 21 mice mouse NNS cord-003926-ycdaw2vh 71 22 [ [ -LRB- cord-003926-ycdaw2vh 71 23 28 28 CD cord-003926-ycdaw2vh 71 24 , , , cord-003926-ycdaw2vh 71 25 30 30 CD cord-003926-ycdaw2vh 71 26 ] ] -RRB- cord-003926-ycdaw2vh 71 27 . . . cord-003926-ycdaw2vh 72 1 A a DT cord-003926-ycdaw2vh 72 2 Phase phase NN cord-003926-ycdaw2vh 72 3 I -PRON- PRP cord-003926-ycdaw2vh 72 4 study study NN cord-003926-ycdaw2vh 72 5 evaluated evaluate VBD cord-003926-ycdaw2vh 72 6 GLS-5700 GLS-5700 NNP cord-003926-ycdaw2vh 72 7 administered administer VBN cord-003926-ycdaw2vh 72 8 via via IN cord-003926-ycdaw2vh 72 9 intradermal intradermal JJ cord-003926-ycdaw2vh 72 10 injection injection NN cord-003926-ycdaw2vh 72 11 ( ( -LRB- cord-003926-ycdaw2vh 72 12 ID ID NNP cord-003926-ycdaw2vh 72 13 ) ) -RRB- cord-003926-ycdaw2vh 72 14 , , , cord-003926-ycdaw2vh 72 15 followed follow VBN cord-003926-ycdaw2vh 72 16 by by IN cord-003926-ycdaw2vh 72 17 electroporation electroporation NN cord-003926-ycdaw2vh 72 18 ( ( -LRB- cord-003926-ycdaw2vh 72 19 EP EP NNP cord-003926-ycdaw2vh 72 20 ) ) -RRB- cord-003926-ycdaw2vh 72 21 at at IN cord-003926-ycdaw2vh 72 22 doses dose NNS cord-003926-ycdaw2vh 72 23 of of IN cord-003926-ycdaw2vh 72 24 either either DT cord-003926-ycdaw2vh 72 25 1 1 CD cord-003926-ycdaw2vh 72 26 or or CC cord-003926-ycdaw2vh 72 27 2 2 CD cord-003926-ycdaw2vh 72 28 mg mg NN cord-003926-ycdaw2vh 72 29 per per IN cord-003926-ycdaw2vh 72 30 vaccinations vaccination NNS cord-003926-ycdaw2vh 72 31 followed follow VBN cord-003926-ycdaw2vh 72 32 immediately immediately RB cord-003926-ycdaw2vh 72 33 by by IN cord-003926-ycdaw2vh 72 34 electroporation electroporation NN cord-003926-ycdaw2vh 72 35 at at IN cord-003926-ycdaw2vh 72 36 baseline baseline NN cord-003926-ycdaw2vh 72 37 , , , cord-003926-ycdaw2vh 72 38 4 4 CD cord-003926-ycdaw2vh 72 39 weeks week NNS cord-003926-ycdaw2vh 72 40 and and CC cord-003926-ycdaw2vh 72 41 12 12 CD cord-003926-ycdaw2vh 72 42 weeks week NNS cord-003926-ycdaw2vh 72 43 [ [ -LRB- cord-003926-ycdaw2vh 72 44 42 42 CD cord-003926-ycdaw2vh 72 45 ] ] -RRB- cord-003926-ycdaw2vh 72 46 . . . cord-003926-ycdaw2vh 73 1 There there EX cord-003926-ycdaw2vh 73 2 were be VBD cord-003926-ycdaw2vh 73 3 no no DT cord-003926-ycdaw2vh 73 4 serious serious JJ cord-003926-ycdaw2vh 73 5 adverse adverse JJ cord-003926-ycdaw2vh 73 6 events event NNS cord-003926-ycdaw2vh 73 7 ( ( -LRB- cord-003926-ycdaw2vh 73 8 SAE SAE NNP cord-003926-ycdaw2vh 73 9 ) ) -RRB- cord-003926-ycdaw2vh 73 10 reported report VBD cord-003926-ycdaw2vh 73 11 as as IN cord-003926-ycdaw2vh 73 12 part part NN cord-003926-ycdaw2vh 73 13 of of IN cord-003926-ycdaw2vh 73 14 the the DT cord-003926-ycdaw2vh 73 15 study study NN cord-003926-ycdaw2vh 73 16 , , , cord-003926-ycdaw2vh 73 17 with with IN cord-003926-ycdaw2vh 73 18 the the DT cord-003926-ycdaw2vh 73 19 most most RBS cord-003926-ycdaw2vh 73 20 frequent frequent JJ cord-003926-ycdaw2vh 73 21 adverse adverse JJ cord-003926-ycdaw2vh 73 22 events event NNS cord-003926-ycdaw2vh 73 23 related relate VBN cord-003926-ycdaw2vh 73 24 to to IN cord-003926-ycdaw2vh 73 25 discomfort discomfort NN cord-003926-ycdaw2vh 73 26 , , , cord-003926-ycdaw2vh 73 27 pain pain NN cord-003926-ycdaw2vh 73 28 , , , cord-003926-ycdaw2vh 73 29 or or CC cord-003926-ycdaw2vh 73 30 swelling swell VBG cord-003926-ycdaw2vh 73 31 at at IN cord-003926-ycdaw2vh 73 32 the the DT cord-003926-ycdaw2vh 73 33 injection injection NN cord-003926-ycdaw2vh 73 34 site site NN cord-003926-ycdaw2vh 73 35 . . . cord-003926-ycdaw2vh 74 1 Seroconversion seroconversion NN cord-003926-ycdaw2vh 74 2 was be VBD cord-003926-ycdaw2vh 74 3 observed observe VBN cord-003926-ycdaw2vh 74 4 in in IN cord-003926-ycdaw2vh 74 5 83 83 CD cord-003926-ycdaw2vh 74 6 % % NN cord-003926-ycdaw2vh 74 7 of of IN cord-003926-ycdaw2vh 74 8 individuals individual NNS cord-003926-ycdaw2vh 74 9 after after IN cord-003926-ycdaw2vh 74 10 two two CD cord-003926-ycdaw2vh 74 11 vaccinations vaccination NNS cord-003926-ycdaw2vh 74 12 and and CC cord-003926-ycdaw2vh 74 13 100 100 CD cord-003926-ycdaw2vh 74 14 % % NN cord-003926-ycdaw2vh 74 15 after after IN cord-003926-ycdaw2vh 74 16 three three CD cord-003926-ycdaw2vh 74 17 vaccinations vaccination NNS cord-003926-ycdaw2vh 74 18 with with IN cord-003926-ycdaw2vh 74 19 GLS-5700 GLS-5700 NNP cord-003926-ycdaw2vh 74 20 [ [ -LRB- cord-003926-ycdaw2vh 74 21 42 42 CD cord-003926-ycdaw2vh 74 22 ] ] -RRB- cord-003926-ycdaw2vh 74 23 . . . cord-003926-ycdaw2vh 75 1 Neutralizing neutralize VBG cord-003926-ycdaw2vh 75 2 antibodies antibody NNS cord-003926-ycdaw2vh 75 3 were be VBD cord-003926-ycdaw2vh 75 4 detected detect VBN cord-003926-ycdaw2vh 75 5 for for IN cord-003926-ycdaw2vh 75 6 62 62 CD cord-003926-ycdaw2vh 75 7 % % NN cord-003926-ycdaw2vh 75 8 of of IN cord-003926-ycdaw2vh 75 9 participants participant NNS cord-003926-ycdaw2vh 75 10 in in IN cord-003926-ycdaw2vh 75 11 a a DT cord-003926-ycdaw2vh 75 12 Vero Vero NNP cord-003926-ycdaw2vh 75 13 - - HYPH cord-003926-ycdaw2vh 75 14 cell cell NN cord-003926-ycdaw2vh 75 15 ( ( -LRB- cord-003926-ycdaw2vh 75 16 monkey monkey NN cord-003926-ycdaw2vh 75 17 kidney kidney NN cord-003926-ycdaw2vh 75 18 cell cell NN cord-003926-ycdaw2vh 75 19 ) ) -RRB- cord-003926-ycdaw2vh 75 20 assay assay NN cord-003926-ycdaw2vh 75 21 , , , cord-003926-ycdaw2vh 75 22 however however RB cord-003926-ycdaw2vh 75 23 , , , cord-003926-ycdaw2vh 75 24 95 95 CD cord-003926-ycdaw2vh 75 25 % % NN cord-003926-ycdaw2vh 75 26 of of IN cord-003926-ycdaw2vh 75 27 participants participant NNS cord-003926-ycdaw2vh 75 28 demonstrated demonstrate VBD cord-003926-ycdaw2vh 75 29 the the DT cord-003926-ycdaw2vh 75 30 ability ability NN cord-003926-ycdaw2vh 75 31 to to TO cord-003926-ycdaw2vh 75 32 neutralize neutralize VB cord-003926-ycdaw2vh 75 33 infection infection NN cord-003926-ycdaw2vh 75 34 of of IN cord-003926-ycdaw2vh 75 35 U87MG U87MG NNP cord-003926-ycdaw2vh 75 36 neuroblastoma neuroblastoma NN cord-003926-ycdaw2vh 75 37 cells cell NNS cord-003926-ycdaw2vh 75 38 [ [ -LRB- cord-003926-ycdaw2vh 75 39 42 42 CD cord-003926-ycdaw2vh 75 40 ] ] -RRB- cord-003926-ycdaw2vh 75 41 . . . cord-003926-ycdaw2vh 76 1 Vaccine vaccine NN cord-003926-ycdaw2vh 76 2 responses response NNS cord-003926-ycdaw2vh 76 3 were be VBD cord-003926-ycdaw2vh 76 4 maintained maintain VBN cord-003926-ycdaw2vh 76 5 through through IN cord-003926-ycdaw2vh 76 6 a a DT cord-003926-ycdaw2vh 76 7 year year NN cord-003926-ycdaw2vh 76 8 of of IN cord-003926-ycdaw2vh 76 9 follow follow NN cord-003926-ycdaw2vh 76 10 - - HYPH cord-003926-ycdaw2vh 76 11 up up NN cord-003926-ycdaw2vh 76 12 . . . cord-003926-ycdaw2vh 77 1 There there EX cord-003926-ycdaw2vh 77 2 was be VBD cord-003926-ycdaw2vh 77 3 no no DT cord-003926-ycdaw2vh 77 4 difference difference NN cord-003926-ycdaw2vh 77 5 in in IN cord-003926-ycdaw2vh 77 6 responses response NNS cord-003926-ycdaw2vh 77 7 based base VBN cord-003926-ycdaw2vh 77 8 on on IN cord-003926-ycdaw2vh 77 9 dose dose JJ cord-003926-ycdaw2vh 77 10 level level NN cord-003926-ycdaw2vh 77 11 . . . cord-003926-ycdaw2vh 78 1 Notably notably RB cord-003926-ycdaw2vh 78 2 , , , cord-003926-ycdaw2vh 78 3 passive passive JJ cord-003926-ycdaw2vh 78 4 transfer transfer NN cord-003926-ycdaw2vh 78 5 of of IN cord-003926-ycdaw2vh 78 6 immune immune JJ cord-003926-ycdaw2vh 78 7 serum serum NN cord-003926-ycdaw2vh 78 8 from from IN cord-003926-ycdaw2vh 78 9 vaccinated vaccinated JJ cord-003926-ycdaw2vh 78 10 participants participant NNS cord-003926-ycdaw2vh 78 11 was be VBD cord-003926-ycdaw2vh 78 12 able able JJ cord-003926-ycdaw2vh 78 13 to to TO cord-003926-ycdaw2vh 78 14 protect protect VB cord-003926-ycdaw2vh 78 15 92 92 CD cord-003926-ycdaw2vh 78 16 % % NN cord-003926-ycdaw2vh 78 17 of of IN cord-003926-ycdaw2vh 78 18 IFNAR IFNAR NNP cord-003926-ycdaw2vh 78 19 mice mouse NNS cord-003926-ycdaw2vh 78 20 against against IN cord-003926-ycdaw2vh 78 21 lethal lethal JJ cord-003926-ycdaw2vh 78 22 infection infection NN cord-003926-ycdaw2vh 78 23 independent independent JJ cord-003926-ycdaw2vh 78 24 of of IN cord-003926-ycdaw2vh 78 25 the the DT cord-003926-ycdaw2vh 78 26 presence presence NN cord-003926-ycdaw2vh 78 27 of of IN cord-003926-ycdaw2vh 78 28 Vero Vero NNP cord-003926-ycdaw2vh 78 29 cell cell NN cord-003926-ycdaw2vh 78 30 neutralizing neutralize VBG cord-003926-ycdaw2vh 78 31 antibodies antibody NNS cord-003926-ycdaw2vh 78 32 [ [ -LRB- cord-003926-ycdaw2vh 78 33 42 42 CD cord-003926-ycdaw2vh 78 34 ] ] -RRB- cord-003926-ycdaw2vh 78 35 . . . cord-003926-ycdaw2vh 79 1 GLS-5700 GLS-5700 NNP cord-003926-ycdaw2vh 79 2 is be VBZ cord-003926-ycdaw2vh 79 3 being be VBG cord-003926-ycdaw2vh 79 4 evaluated evaluate VBN cord-003926-ycdaw2vh 79 5 as as IN cord-003926-ycdaw2vh 79 6 part part NN cord-003926-ycdaw2vh 79 7 of of IN cord-003926-ycdaw2vh 79 8 a a DT cord-003926-ycdaw2vh 79 9 second second JJ cord-003926-ycdaw2vh 79 10 double double JJ cord-003926-ycdaw2vh 79 11 - - HYPH cord-003926-ycdaw2vh 79 12 blind blind JJ cord-003926-ycdaw2vh 79 13 , , , cord-003926-ycdaw2vh 79 14 placebo placebo NN cord-003926-ycdaw2vh 79 15 - - HYPH cord-003926-ycdaw2vh 79 16 controlled control VBN cord-003926-ycdaw2vh 79 17 clinical clinical JJ cord-003926-ycdaw2vh 79 18 trial trial NN cord-003926-ycdaw2vh 79 19 ( ( -LRB- cord-003926-ycdaw2vh 79 20 NCT02887482 NCT02887482 NNP cord-003926-ycdaw2vh 79 21 ) ) -RRB- cord-003926-ycdaw2vh 79 22 performed perform VBN cord-003926-ycdaw2vh 79 23 in in IN cord-003926-ycdaw2vh 79 24 Puerto Puerto NNP cord-003926-ycdaw2vh 79 25 Rico Rico NNP cord-003926-ycdaw2vh 79 26 . . . cord-003926-ycdaw2vh 80 1 Analysis analysis NN cord-003926-ycdaw2vh 80 2 of of IN cord-003926-ycdaw2vh 80 3 the the DT cord-003926-ycdaw2vh 80 4 latter latter JJ cord-003926-ycdaw2vh 80 5 study study NN cord-003926-ycdaw2vh 80 6 is be VBZ cord-003926-ycdaw2vh 80 7 in in IN cord-003926-ycdaw2vh 80 8 progress progress NN cord-003926-ycdaw2vh 80 9 . . . cord-003926-ycdaw2vh 81 1 Two two CD cord-003926-ycdaw2vh 81 2 additional additional JJ cord-003926-ycdaw2vh 81 3 DNA dna NN cord-003926-ycdaw2vh 81 4 vaccines vaccine NNS cord-003926-ycdaw2vh 81 5 , , , cord-003926-ycdaw2vh 81 6 based base VBN cord-003926-ycdaw2vh 81 7 on on IN cord-003926-ycdaw2vh 81 8 the the DT cord-003926-ycdaw2vh 81 9 French french JJ cord-003926-ycdaw2vh 81 10 Polynesian Polynesian NNP cord-003926-ycdaw2vh 81 11 H H NNP cord-003926-ycdaw2vh 81 12 / / SYM cord-003926-ycdaw2vh 81 13 PF/2013 PF/2013 NNP cord-003926-ycdaw2vh 81 14 strain strain NN cord-003926-ycdaw2vh 81 15 were be VBD cord-003926-ycdaw2vh 81 16 developed develop VBN cord-003926-ycdaw2vh 81 17 as as IN cord-003926-ycdaw2vh 81 18 chimeras chimera NNS cord-003926-ycdaw2vh 81 19 that that WDT cord-003926-ycdaw2vh 81 20 included include VBD cord-003926-ycdaw2vh 81 21 the the DT cord-003926-ycdaw2vh 81 22 JEV JEV NNP cord-003926-ycdaw2vh 81 23 prM prm JJ cord-003926-ycdaw2vh 81 24 signal signal NN cord-003926-ycdaw2vh 81 25 sequence sequence NN cord-003926-ycdaw2vh 81 26 followed follow VBN cord-003926-ycdaw2vh 81 27 by by IN cord-003926-ycdaw2vh 81 28 the the DT cord-003926-ycdaw2vh 81 29 Zika Zika NNP cord-003926-ycdaw2vh 81 30 envelope envelope NN cord-003926-ycdaw2vh 81 31 ( ( -LRB- cord-003926-ycdaw2vh 81 32 E e NN cord-003926-ycdaw2vh 81 33 ) ) -RRB- cord-003926-ycdaw2vh 81 34 gene gene NN cord-003926-ycdaw2vh 81 35 ( ( -LRB- cord-003926-ycdaw2vh 81 36 VRC5283 VRC5283 NNP cord-003926-ycdaw2vh 81 37 ) ) -RRB- cord-003926-ycdaw2vh 81 38 or or CC cord-003926-ycdaw2vh 81 39 a a DT cord-003926-ycdaw2vh 81 40 similar similar JJ cord-003926-ycdaw2vh 81 41 construct construct NN cord-003926-ycdaw2vh 81 42 with with IN cord-003926-ycdaw2vh 81 43 the the DT cord-003926-ycdaw2vh 81 44 terminal terminal JJ cord-003926-ycdaw2vh 81 45 98 98 CD cord-003926-ycdaw2vh 81 46 amino amino NN cord-003926-ycdaw2vh 81 47 acids acid NNS cord-003926-ycdaw2vh 81 48 of of IN cord-003926-ycdaw2vh 81 49 E e NN cord-003926-ycdaw2vh 81 50 , , , cord-003926-ycdaw2vh 81 51 representing represent VBG cord-003926-ycdaw2vh 81 52 the the DT cord-003926-ycdaw2vh 81 53 stem stem NN cord-003926-ycdaw2vh 81 54 and and CC cord-003926-ycdaw2vh 81 55 transmembrane transmembrane NN cord-003926-ycdaw2vh 81 56 regions region NNS cord-003926-ycdaw2vh 81 57 , , , cord-003926-ycdaw2vh 81 58 exchanged exchange VBD cord-003926-ycdaw2vh 81 59 for for IN cord-003926-ycdaw2vh 81 60 the the DT cord-003926-ycdaw2vh 81 61 analogous analogous JJ cord-003926-ycdaw2vh 81 62 JEV JEV NNP cord-003926-ycdaw2vh 81 63 sequence sequence NN cord-003926-ycdaw2vh 81 64 ( ( -LRB- cord-003926-ycdaw2vh 81 65 VRC5288 VRC5288 NNP cord-003926-ycdaw2vh 81 66 ) ) -RRB- cord-003926-ycdaw2vh 81 67 [ [ -LRB- cord-003926-ycdaw2vh 81 68 44 44 CD cord-003926-ycdaw2vh 81 69 ] ] -RRB- cord-003926-ycdaw2vh 81 70 . . . cord-003926-ycdaw2vh 82 1 Both both DT cord-003926-ycdaw2vh 82 2 vaccines vaccine NNS cord-003926-ycdaw2vh 82 3 were be VBD cord-003926-ycdaw2vh 82 4 immunogenic immunogenic JJ cord-003926-ycdaw2vh 82 5 for for IN cord-003926-ycdaw2vh 82 6 mice mouse NNS cord-003926-ycdaw2vh 82 7 and and CC cord-003926-ycdaw2vh 82 8 NHPs nhp NNS cord-003926-ycdaw2vh 82 9 and and CC cord-003926-ycdaw2vh 82 10 protected protect VBN cord-003926-ycdaw2vh 82 11 > > XX cord-003926-ycdaw2vh 82 12 90 90 CD cord-003926-ycdaw2vh 82 13 % % NN cord-003926-ycdaw2vh 82 14 of of IN cord-003926-ycdaw2vh 82 15 NHPs nhp NNS cord-003926-ycdaw2vh 82 16 against against IN cord-003926-ycdaw2vh 82 17 viremia viremia NN cord-003926-ycdaw2vh 82 18 at at IN cord-003926-ycdaw2vh 82 19 a a DT cord-003926-ycdaw2vh 82 20 dose dose NN cord-003926-ycdaw2vh 82 21 of of IN cord-003926-ycdaw2vh 83 1 either either CC cord-003926-ycdaw2vh 83 2 1 1 CD cord-003926-ycdaw2vh 83 3 or or CC cord-003926-ycdaw2vh 83 4 4 4 CD cord-003926-ycdaw2vh 83 5 mg mg NNS cord-003926-ycdaw2vh 83 6 given give VBN cord-003926-ycdaw2vh 83 7 twice twice PDT cord-003926-ycdaw2vh 83 8 [ [ -LRB- cord-003926-ycdaw2vh 83 9 44 44 CD cord-003926-ycdaw2vh 83 10 ] ] -RRB- cord-003926-ycdaw2vh 83 11 . . . cord-003926-ycdaw2vh 84 1 Both both DT cord-003926-ycdaw2vh 84 2 vaccine vaccine NN cord-003926-ycdaw2vh 84 3 candidates candidate NNS cord-003926-ycdaw2vh 84 4 were be VBD cord-003926-ycdaw2vh 84 5 advanced advance VBN cord-003926-ycdaw2vh 84 6 into into IN cord-003926-ycdaw2vh 84 7 clinical clinical JJ cord-003926-ycdaw2vh 84 8 trials trial NNS cord-003926-ycdaw2vh 84 9 with with IN cord-003926-ycdaw2vh 84 10 4 4 CD cord-003926-ycdaw2vh 84 11 mg mg NN cord-003926-ycdaw2vh 84 12 of of IN cord-003926-ycdaw2vh 84 13 administered administer VBN cord-003926-ycdaw2vh 84 14 intramuscularly intramuscularly RB cord-003926-ycdaw2vh 84 15 at at IN cord-003926-ycdaw2vh 84 16 weeks week NNS cord-003926-ycdaw2vh 84 17 0 0 CD cord-003926-ycdaw2vh 84 18 , , , cord-003926-ycdaw2vh 84 19 4 4 CD cord-003926-ycdaw2vh 84 20 and and CC cord-003926-ycdaw2vh 84 21 8 8 CD cord-003926-ycdaw2vh 84 22 with with IN cord-003926-ycdaw2vh 84 23 vaccine vaccine NN cord-003926-ycdaw2vh 84 24 VRC5288 VRC5288 NNP cord-003926-ycdaw2vh 84 25 administered administer VBN cord-003926-ycdaw2vh 84 26 by by IN cord-003926-ycdaw2vh 84 27 needle needle NN cord-003926-ycdaw2vh 84 28 and and CC cord-003926-ycdaw2vh 84 29 syringe syringe NN cord-003926-ycdaw2vh 84 30 while while IN cord-003926-ycdaw2vh 84 31 VRC5283 VRC5283 NNP cord-003926-ycdaw2vh 84 32 was be VBD cord-003926-ycdaw2vh 84 33 administered administer VBN cord-003926-ycdaw2vh 84 34 either either CC cord-003926-ycdaw2vh 84 35 as as IN cord-003926-ycdaw2vh 84 36 a a DT cord-003926-ycdaw2vh 84 37 single single JJ cord-003926-ycdaw2vh 84 38 dose dose NN cord-003926-ycdaw2vh 84 39 or or CC cord-003926-ycdaw2vh 84 40 split split JJ cord-003926-ycdaw2vh 84 41 dose dose NN cord-003926-ycdaw2vh 84 42 by by IN cord-003926-ycdaw2vh 84 43 needle needle NN cord-003926-ycdaw2vh 84 44 and and CC cord-003926-ycdaw2vh 84 45 syringe syringe NN cord-003926-ycdaw2vh 84 46 or or CC cord-003926-ycdaw2vh 84 47 as as IN cord-003926-ycdaw2vh 84 48 a a DT cord-003926-ycdaw2vh 84 49 split split NN cord-003926-ycdaw2vh 84 50 dose dose NN cord-003926-ycdaw2vh 84 51 given give VBN cord-003926-ycdaw2vh 84 52 by by IN cord-003926-ycdaw2vh 84 53 the the DT cord-003926-ycdaw2vh 84 54 Pharmajet Pharmajet NNP cord-003926-ycdaw2vh 84 55 needle needle NN cord-003926-ycdaw2vh 84 56 - - HYPH cord-003926-ycdaw2vh 84 57 free free JJ cord-003926-ycdaw2vh 84 58 device device NN cord-003926-ycdaw2vh 84 59 [ [ -LRB- cord-003926-ycdaw2vh 84 60 41 41 CD cord-003926-ycdaw2vh 84 61 ] ] -RRB- cord-003926-ycdaw2vh 84 62 . . . cord-003926-ycdaw2vh 85 1 Seroconversion seroconversion NN cord-003926-ycdaw2vh 85 2 was be VBD cord-003926-ycdaw2vh 85 3 100 100 CD cord-003926-ycdaw2vh 85 4 % % NN cord-003926-ycdaw2vh 85 5 in in IN cord-003926-ycdaw2vh 85 6 the the DT cord-003926-ycdaw2vh 85 7 group group NN cord-003926-ycdaw2vh 85 8 administered administer VBD cord-003926-ycdaw2vh 85 9 vaccine vaccine NN cord-003926-ycdaw2vh 85 10 with with IN cord-003926-ycdaw2vh 85 11 the the DT cord-003926-ycdaw2vh 85 12 needle needle NN cord-003926-ycdaw2vh 85 13 - - HYPH cord-003926-ycdaw2vh 85 14 free free JJ cord-003926-ycdaw2vh 85 15 device device NN cord-003926-ycdaw2vh 85 16 , , , cord-003926-ycdaw2vh 85 17 less less JJR cord-003926-ycdaw2vh 85 18 for for IN cord-003926-ycdaw2vh 85 19 vaccine vaccine NN cord-003926-ycdaw2vh 85 20 administered administer VBN cord-003926-ycdaw2vh 85 21 as as IN cord-003926-ycdaw2vh 85 22 split split NN cord-003926-ycdaw2vh 85 23 - - HYPH cord-003926-ycdaw2vh 85 24 dose dose NN cord-003926-ycdaw2vh 85 25 by by IN cord-003926-ycdaw2vh 85 26 needle needle NN cord-003926-ycdaw2vh 85 27 and and CC cord-003926-ycdaw2vh 85 28 syringe syringe NN cord-003926-ycdaw2vh 85 29 , , , cord-003926-ycdaw2vh 85 30 and and CC cord-003926-ycdaw2vh 85 31 lowest low JJS cord-003926-ycdaw2vh 85 32 for for IN cord-003926-ycdaw2vh 85 33 vaccine vaccine NN cord-003926-ycdaw2vh 85 34 given give VBN cord-003926-ycdaw2vh 85 35 as as IN cord-003926-ycdaw2vh 85 36 a a DT cord-003926-ycdaw2vh 85 37 single single JJ cord-003926-ycdaw2vh 85 38 injection injection NN cord-003926-ycdaw2vh 85 39 with with IN cord-003926-ycdaw2vh 85 40 needle needle NN cord-003926-ycdaw2vh 85 41 and and CC cord-003926-ycdaw2vh 85 42 syringe syringe NN cord-003926-ycdaw2vh 85 43 . . . cord-003926-ycdaw2vh 86 1 The the DT cord-003926-ycdaw2vh 86 2 VRC5283 VRC5283 NNP cord-003926-ycdaw2vh 86 3 vaccine vaccine NN cord-003926-ycdaw2vh 86 4 was be VBD cord-003926-ycdaw2vh 86 5 advanced advance VBN cord-003926-ycdaw2vh 86 6 into into IN cord-003926-ycdaw2vh 86 7 Phase Phase NNP cord-003926-ycdaw2vh 86 8 II II NNP cord-003926-ycdaw2vh 86 9 studies study NNS cord-003926-ycdaw2vh 86 10 in in IN cord-003926-ycdaw2vh 86 11 the the DT cord-003926-ycdaw2vh 86 12 Americas Americas NNPS cord-003926-ycdaw2vh 86 13 that that WDT cord-003926-ycdaw2vh 86 14 utilized utilize VBD cord-003926-ycdaw2vh 86 15 140 140 CD cord-003926-ycdaw2vh 86 16 clinical clinical JJ cord-003926-ycdaw2vh 86 17 sites site NNS cord-003926-ycdaw2vh 86 18 with with IN cord-003926-ycdaw2vh 86 19 clinical clinical JJ cord-003926-ycdaw2vh 86 20 site site NN cord-003926-ycdaw2vh 86 21 selection selection NN cord-003926-ycdaw2vh 86 22 guided guide VBN cord-003926-ycdaw2vh 86 23 by by IN cord-003926-ycdaw2vh 86 24 epidemiologic epidemiologic JJ cord-003926-ycdaw2vh 86 25 modeling modeling NN cord-003926-ycdaw2vh 86 26 [ [ -LRB- cord-003926-ycdaw2vh 86 27 38 38 CD cord-003926-ycdaw2vh 86 28 ] ] -RRB- cord-003926-ycdaw2vh 86 29 . . . cord-003926-ycdaw2vh 87 1 Long long JJ cord-003926-ycdaw2vh 87 2 - - HYPH cord-003926-ycdaw2vh 87 3 term term NN cord-003926-ycdaw2vh 87 4 follow follow NN cord-003926-ycdaw2vh 87 5 - - HYPH cord-003926-ycdaw2vh 87 6 up up NN cord-003926-ycdaw2vh 87 7 has have VBZ cord-003926-ycdaw2vh 87 8 not not RB cord-003926-ycdaw2vh 87 9 been be VBN cord-003926-ycdaw2vh 87 10 reported report VBN cord-003926-ycdaw2vh 87 11 . . . cord-003926-ycdaw2vh 88 1 Three three CD cord-003926-ycdaw2vh 88 2 inactivated inactivate VBN cord-003926-ycdaw2vh 88 3 vaccines vaccine NNS cord-003926-ycdaw2vh 88 4 have have VBP cord-003926-ycdaw2vh 88 5 entered enter VBN cord-003926-ycdaw2vh 88 6 into into IN cord-003926-ycdaw2vh 88 7 clinical clinical JJ cord-003926-ycdaw2vh 88 8 studies study NNS cord-003926-ycdaw2vh 88 9 , , , cord-003926-ycdaw2vh 88 10 of of IN cord-003926-ycdaw2vh 88 11 which which WDT cord-003926-ycdaw2vh 88 12 clinical clinical JJ cord-003926-ycdaw2vh 88 13 data datum NNS cord-003926-ycdaw2vh 88 14 for for IN cord-003926-ycdaw2vh 88 15 only only JJ cord-003926-ycdaw2vh 88 16 ZPIV ZPIV NNP cord-003926-ycdaw2vh 88 17 vaccine vaccine NN cord-003926-ycdaw2vh 88 18 has have VBZ cord-003926-ycdaw2vh 88 19 been be VBN cord-003926-ycdaw2vh 88 20 published publish VBN cord-003926-ycdaw2vh 88 21 [ [ -LRB- cord-003926-ycdaw2vh 88 22 45 45 CD cord-003926-ycdaw2vh 88 23 ] ] -RRB- cord-003926-ycdaw2vh 88 24 . . . cord-003926-ycdaw2vh 89 1 ZPIV ZPIV NNP cord-003926-ycdaw2vh 89 2 is be VBZ cord-003926-ycdaw2vh 89 3 a a DT cord-003926-ycdaw2vh 89 4 whole whole JJ cord-003926-ycdaw2vh 89 5 inactivated inactivate VBN cord-003926-ycdaw2vh 89 6 virus virus NN cord-003926-ycdaw2vh 89 7 vaccine vaccine NN cord-003926-ycdaw2vh 89 8 of of IN cord-003926-ycdaw2vh 89 9 Puerto puerto JJ cord-003926-ycdaw2vh 89 10 Rican rican JJ cord-003926-ycdaw2vh 89 11 strain strain NN cord-003926-ycdaw2vh 90 1 PRVABC59 PRVABC59 NNP cord-003926-ycdaw2vh 90 2 [ [ -LRB- cord-003926-ycdaw2vh 90 3 46 46 CD cord-003926-ycdaw2vh 90 4 ] ] -RRB- cord-003926-ycdaw2vh 90 5 . . . cord-003926-ycdaw2vh 91 1 Studies study NNS cord-003926-ycdaw2vh 91 2 in in IN cord-003926-ycdaw2vh 91 3 mice mouse NNS cord-003926-ycdaw2vh 91 4 showed show VBD cord-003926-ycdaw2vh 91 5 that that IN cord-003926-ycdaw2vh 91 6 a a DT cord-003926-ycdaw2vh 91 7 single single JJ cord-003926-ycdaw2vh 91 8 vaccination vaccination NN cord-003926-ycdaw2vh 91 9 given give VBN cord-003926-ycdaw2vh 91 10 intramuscularly intramuscularly RB cord-003926-ycdaw2vh 91 11 with with IN cord-003926-ycdaw2vh 91 12 alum alum NN cord-003926-ycdaw2vh 91 13 generated generate VBD cord-003926-ycdaw2vh 91 14 antibody antibody NN cord-003926-ycdaw2vh 91 15 titers titer NNS cord-003926-ycdaw2vh 91 16 of of IN cord-003926-ycdaw2vh 91 17 approximately approximately RB cord-003926-ycdaw2vh 91 18 3.7 3.7 CD cord-003926-ycdaw2vh 91 19 log10 log10 NNS cord-003926-ycdaw2vh 91 20 and and CC cord-003926-ycdaw2vh 91 21 fully fully RB cord-003926-ycdaw2vh 91 22 protected protect VBN cord-003926-ycdaw2vh 91 23 Balb Balb NNP cord-003926-ycdaw2vh 91 24 / / SYM cord-003926-ycdaw2vh 91 25 C c NN cord-003926-ycdaw2vh 91 26 immunocompetent immunocompetent JJ cord-003926-ycdaw2vh 91 27 mice mouse NNS cord-003926-ycdaw2vh 91 28 from from IN cord-003926-ycdaw2vh 91 29 viremia viremia NN cord-003926-ycdaw2vh 91 30 , , , cord-003926-ycdaw2vh 91 31 whereas whereas IN cord-003926-ycdaw2vh 91 32 unvaccinated unvaccinated JJ cord-003926-ycdaw2vh 91 33 mice mouse NNS cord-003926-ycdaw2vh 91 34 were be VBD cord-003926-ycdaw2vh 91 35 unprotected unprotected JJ cord-003926-ycdaw2vh 91 36 and and CC cord-003926-ycdaw2vh 91 37 subcutaneously subcutaneously RB cord-003926-ycdaw2vh 91 38 vaccinated vaccinate VBN cord-003926-ycdaw2vh 91 39 mice mouse NNS cord-003926-ycdaw2vh 91 40 were be VBD cord-003926-ycdaw2vh 91 41 only only RB cord-003926-ycdaw2vh 91 42 partially partially RB cord-003926-ycdaw2vh 91 43 protected protect VBN cord-003926-ycdaw2vh 91 44 against against IN cord-003926-ycdaw2vh 91 45 the the DT cord-003926-ycdaw2vh 91 46 Zika Zika NNP cord-003926-ycdaw2vh 91 47 Brazil Brazil NNP cord-003926-ycdaw2vh 91 48 strain strain VBP cord-003926-ycdaw2vh 91 49 [ [ -LRB- cord-003926-ycdaw2vh 91 50 46 46 CD cord-003926-ycdaw2vh 91 51 ] ] -RRB- cord-003926-ycdaw2vh 91 52 . . . cord-003926-ycdaw2vh 92 1 A a DT cord-003926-ycdaw2vh 92 2 subsequent subsequent JJ cord-003926-ycdaw2vh 92 3 study study NN cord-003926-ycdaw2vh 92 4 in in IN cord-003926-ycdaw2vh 92 5 non non JJ cord-003926-ycdaw2vh 92 6 - - JJ cord-003926-ycdaw2vh 92 7 human human JJ cord-003926-ycdaw2vh 92 8 primates primate NNS cord-003926-ycdaw2vh 92 9 vaccinated vaccinate VBN cord-003926-ycdaw2vh 92 10 twice twice RB cord-003926-ycdaw2vh 92 11 at at IN cord-003926-ycdaw2vh 92 12 four four CD cord-003926-ycdaw2vh 92 13 - - HYPH cord-003926-ycdaw2vh 92 14 week week NN cord-003926-ycdaw2vh 92 15 intervals interval NNS cord-003926-ycdaw2vh 92 16 with with IN cord-003926-ycdaw2vh 92 17 alum alum NN cord-003926-ycdaw2vh 92 18 generated generate VBD cord-003926-ycdaw2vh 92 19 binding binding NN cord-003926-ycdaw2vh 92 20 and and CC cord-003926-ycdaw2vh 92 21 microneutralization microneutralization NN cord-003926-ycdaw2vh 92 22 antibody antibody NN cord-003926-ycdaw2vh 92 23 titers titer NNS cord-003926-ycdaw2vh 92 24 of of IN cord-003926-ycdaw2vh 92 25 3.54 3.54 CD cord-003926-ycdaw2vh 92 26 and and CC cord-003926-ycdaw2vh 92 27 3.55 3.55 CD cord-003926-ycdaw2vh 92 28 log10 log10 NNS cord-003926-ycdaw2vh 92 29 , , , cord-003926-ycdaw2vh 92 30 respectively respectively RB cord-003926-ycdaw2vh 92 31 , , , cord-003926-ycdaw2vh 92 32 and and CC cord-003926-ycdaw2vh 92 33 complete complete JJ cord-003926-ycdaw2vh 92 34 protection protection NN cord-003926-ycdaw2vh 92 35 against against IN cord-003926-ycdaw2vh 92 36 viremia viremia NN cord-003926-ycdaw2vh 92 37 and and CC cord-003926-ycdaw2vh 92 38 viruria viruria NN cord-003926-ycdaw2vh 92 39 following follow VBG cord-003926-ycdaw2vh 92 40 challenge challenge NN cord-003926-ycdaw2vh 92 41 with with IN cord-003926-ycdaw2vh 92 42 either either CC cord-003926-ycdaw2vh 92 43 Brazilian brazilian JJ cord-003926-ycdaw2vh 92 44 or or CC cord-003926-ycdaw2vh 92 45 Puerto puerto JJ cord-003926-ycdaw2vh 92 46 Rican rican JJ cord-003926-ycdaw2vh 92 47 strains strain NNS cord-003926-ycdaw2vh 92 48 of of IN cord-003926-ycdaw2vh 92 49 Zika Zika NNP cord-003926-ycdaw2vh 92 50 virus virus NN cord-003926-ycdaw2vh 92 51 [ [ -LRB- cord-003926-ycdaw2vh 92 52 47 47 CD cord-003926-ycdaw2vh 92 53 ] ] -RRB- cord-003926-ycdaw2vh 92 54 . . . cord-003926-ycdaw2vh 93 1 ZPIV ZPIV NNP cord-003926-ycdaw2vh 93 2 safety safety NN cord-003926-ycdaw2vh 93 3 and and CC cord-003926-ycdaw2vh 93 4 immunogenicity immunogenicity NN cord-003926-ycdaw2vh 93 5 was be VBD cord-003926-ycdaw2vh 93 6 tested test VBN cord-003926-ycdaw2vh 93 7 in in IN cord-003926-ycdaw2vh 93 8 three three CD cord-003926-ycdaw2vh 93 9 clinical clinical JJ cord-003926-ycdaw2vh 93 10 trials trial NNS cord-003926-ycdaw2vh 93 11 to to TO cord-003926-ycdaw2vh 93 12 assess assess VB cord-003926-ycdaw2vh 93 13 Zika Zika NNP cord-003926-ycdaw2vh 93 14 vaccine vaccine NN cord-003926-ycdaw2vh 93 15 responses response NNS cord-003926-ycdaw2vh 93 16 relative relative JJ cord-003926-ycdaw2vh 93 17 to to IN cord-003926-ycdaw2vh 93 18 dose dose JJ cord-003926-ycdaw2vh 93 19 level level NN cord-003926-ycdaw2vh 93 20 , , , cord-003926-ycdaw2vh 93 21 vaccination vaccination NN cord-003926-ycdaw2vh 93 22 schedule schedule NN cord-003926-ycdaw2vh 93 23 , , , cord-003926-ycdaw2vh 93 24 or or CC cord-003926-ycdaw2vh 93 25 following follow VBG cord-003926-ycdaw2vh 93 26 vaccination vaccination NN cord-003926-ycdaw2vh 93 27 with with IN cord-003926-ycdaw2vh 93 28 either either CC cord-003926-ycdaw2vh 93 29 the the DT cord-003926-ycdaw2vh 93 30 Yellow Yellow NNP cord-003926-ycdaw2vh 93 31 Fever Fever NNP cord-003926-ycdaw2vh 93 32 YF YF NNP cord-003926-ycdaw2vh 93 33 - - HYPH cord-003926-ycdaw2vh 93 34 VAX VAX NNP cord-003926-ycdaw2vh 93 35 or or CC cord-003926-ycdaw2vh 93 36 Japanese japanese JJ cord-003926-ycdaw2vh 93 37 encephalitis encephalitis NN cord-003926-ycdaw2vh 93 38 virus virus NN cord-003926-ycdaw2vh 93 39 ( ( -LRB- cord-003926-ycdaw2vh 93 40 JEV JEV NNP cord-003926-ycdaw2vh 93 41 ) ) -RRB- cord-003926-ycdaw2vh 94 1 IXARO IXARO NNP cord-003926-ycdaw2vh 94 2 vaccines vaccine NNS cord-003926-ycdaw2vh 95 1 to to TO cord-003926-ycdaw2vh 95 2 assess assess VB cord-003926-ycdaw2vh 95 3 responses response NNS cord-003926-ycdaw2vh 95 4 in in IN cord-003926-ycdaw2vh 95 5 a a DT cord-003926-ycdaw2vh 95 6 flavivirus flavivirus JJ cord-003926-ycdaw2vh 95 7 - - HYPH cord-003926-ycdaw2vh 95 8 exposed expose VBN cord-003926-ycdaw2vh 95 9 population population NN cord-003926-ycdaw2vh 95 10 [ [ -LRB- cord-003926-ycdaw2vh 95 11 45 45 CD cord-003926-ycdaw2vh 95 12 ] ] -RRB- cord-003926-ycdaw2vh 95 13 . . . cord-003926-ycdaw2vh 96 1 There there EX cord-003926-ycdaw2vh 96 2 were be VBD cord-003926-ycdaw2vh 96 3 no no DT cord-003926-ycdaw2vh 96 4 vaccine vaccine NN cord-003926-ycdaw2vh 96 5 - - HYPH cord-003926-ycdaw2vh 96 6 associated associate VBN cord-003926-ycdaw2vh 96 7 SAEs SAEs NNP cord-003926-ycdaw2vh 96 8 reported report VBD cord-003926-ycdaw2vh 96 9 . . . cord-003926-ycdaw2vh 97 1 The the DT cord-003926-ycdaw2vh 97 2 most most RBS cord-003926-ycdaw2vh 97 3 common common JJ cord-003926-ycdaw2vh 97 4 adverse adverse JJ cord-003926-ycdaw2vh 97 5 events event NNS cord-003926-ycdaw2vh 97 6 were be VBD cord-003926-ycdaw2vh 97 7 pain pain NN cord-003926-ycdaw2vh 97 8 and and CC cord-003926-ycdaw2vh 97 9 tenderness tenderness NN cord-003926-ycdaw2vh 97 10 at at IN cord-003926-ycdaw2vh 97 11 the the DT cord-003926-ycdaw2vh 97 12 injection injection NN cord-003926-ycdaw2vh 97 13 site site NN cord-003926-ycdaw2vh 97 14 ; ; : cord-003926-ycdaw2vh 97 15 no no DT cord-003926-ycdaw2vh 97 16 neurologic neurologic JJ cord-003926-ycdaw2vh 97 17 events event NNS cord-003926-ycdaw2vh 97 18 were be VBD cord-003926-ycdaw2vh 97 19 reported report VBN cord-003926-ycdaw2vh 97 20 . . . cord-003926-ycdaw2vh 98 1 Seroconversion seroconversion NN cord-003926-ycdaw2vh 98 2 was be VBD cord-003926-ycdaw2vh 98 3 92 92 CD cord-003926-ycdaw2vh 98 4 % % NN cord-003926-ycdaw2vh 98 5 using use VBG cord-003926-ycdaw2vh 98 6 a a DT cord-003926-ycdaw2vh 98 7 cutoff cutoff NN cord-003926-ycdaw2vh 98 8 for for IN cord-003926-ycdaw2vh 98 9 peak peak NN cord-003926-ycdaw2vh 99 1 geometric geometric JJ cord-003926-ycdaw2vh 99 2 mean mean JJ cord-003926-ycdaw2vh 99 3 titer titer NN cord-003926-ycdaw2vh 99 4 of of IN cord-003926-ycdaw2vh 99 5 1:10 1:10 CD cord-003926-ycdaw2vh 99 6 and and CC cord-003926-ycdaw2vh 99 7 77 77 CD cord-003926-ycdaw2vh 99 8 % % NN cord-003926-ycdaw2vh 99 9 using use VBG cord-003926-ycdaw2vh 99 10 a a DT cord-003926-ycdaw2vh 99 11 titer titer NN cord-003926-ycdaw2vh 99 12 of of IN cord-003926-ycdaw2vh 99 13 1:100 1:100 CD cord-003926-ycdaw2vh 99 14 . . . cord-003926-ycdaw2vh 100 1 Response response NN cord-003926-ycdaw2vh 100 2 rates rate NNS cord-003926-ycdaw2vh 100 3 after after IN cord-003926-ycdaw2vh 100 4 a a DT cord-003926-ycdaw2vh 100 5 single single JJ cord-003926-ycdaw2vh 100 6 immunization immunization NN cord-003926-ycdaw2vh 100 7 were be VBD cord-003926-ycdaw2vh 100 8 11 11 CD cord-003926-ycdaw2vh 100 9 % % NN cord-003926-ycdaw2vh 100 10 and and CC cord-003926-ycdaw2vh 100 11 5.5 5.5 CD cord-003926-ycdaw2vh 100 12 % % NN cord-003926-ycdaw2vh 100 13 using use VBG cord-003926-ycdaw2vh 100 14 cutoffs cutoff NNS cord-003926-ycdaw2vh 100 15 of of IN cord-003926-ycdaw2vh 100 16 1:10 1:10 CD cord-003926-ycdaw2vh 100 17 or or CC cord-003926-ycdaw2vh 100 18 1:100 1:100 CD cord-003926-ycdaw2vh 100 19 , , , cord-003926-ycdaw2vh 100 20 respectively respectively RB cord-003926-ycdaw2vh 100 21 . . . cord-003926-ycdaw2vh 101 1 Vaccine vaccine NN cord-003926-ycdaw2vh 101 2 responses response NNS cord-003926-ycdaw2vh 101 3 were be VBD cord-003926-ycdaw2vh 101 4 observed observe VBN cord-003926-ycdaw2vh 101 5 through through IN cord-003926-ycdaw2vh 101 6 day day NN cord-003926-ycdaw2vh 101 7 57 57 CD cord-003926-ycdaw2vh 101 8 . . . cord-003926-ycdaw2vh 102 1 Passive passive JJ cord-003926-ycdaw2vh 102 2 transfer transfer NN cord-003926-ycdaw2vh 102 3 of of IN cord-003926-ycdaw2vh 102 4 purified purify VBN cord-003926-ycdaw2vh 102 5 IgG igg NN cord-003926-ycdaw2vh 102 6 derived derive VBN cord-003926-ycdaw2vh 102 7 from from IN cord-003926-ycdaw2vh 102 8 10 10 CD cord-003926-ycdaw2vh 102 9 Zika Zika NNP cord-003926-ycdaw2vh 102 10 immunized immunize VBD cord-003926-ycdaw2vh 102 11 participants participant NNS cord-003926-ycdaw2vh 102 12 to to IN cord-003926-ycdaw2vh 102 13 groups group NNS cord-003926-ycdaw2vh 102 14 of of IN cord-003926-ycdaw2vh 102 15 5 5 CD cord-003926-ycdaw2vh 102 16 Balb Balb NNP cord-003926-ycdaw2vh 102 17 / / SYM cord-003926-ycdaw2vh 102 18 C c NN cord-003926-ycdaw2vh 102 19 mice mouse NNS cord-003926-ycdaw2vh 102 20 per per IN cord-003926-ycdaw2vh 102 21 participant participant NN cord-003926-ycdaw2vh 102 22 provided provide VBD cord-003926-ycdaw2vh 102 23 sterilizing sterilize VBG cord-003926-ycdaw2vh 102 24 immunity immunity NN cord-003926-ycdaw2vh 102 25 against against IN cord-003926-ycdaw2vh 102 26 viremia viremia NN cord-003926-ycdaw2vh 102 27 for for IN cord-003926-ycdaw2vh 102 28 82 82 CD cord-003926-ycdaw2vh 102 29 % % NN cord-003926-ycdaw2vh 102 30 ( ( -LRB- cord-003926-ycdaw2vh 102 31 41 41 CD cord-003926-ycdaw2vh 102 32 of of IN cord-003926-ycdaw2vh 102 33 50 50 CD cord-003926-ycdaw2vh 102 34 ) ) -RRB- cord-003926-ycdaw2vh 102 35 of of IN cord-003926-ycdaw2vh 102 36 mice mouse NNS cord-003926-ycdaw2vh 102 37 overall overall RB cord-003926-ycdaw2vh 102 38 , , , cord-003926-ycdaw2vh 102 39 with with IN cord-003926-ycdaw2vh 102 40 viremia viremia NN cord-003926-ycdaw2vh 102 41 observed observe VBN cord-003926-ycdaw2vh 102 42 for for IN cord-003926-ycdaw2vh 102 43 one one CD cord-003926-ycdaw2vh 102 44 or or CC cord-003926-ycdaw2vh 102 45 more more JJR cord-003926-ycdaw2vh 102 46 mice mouse NNS cord-003926-ycdaw2vh 102 47 per per IN cord-003926-ycdaw2vh 102 48 group group NN cord-003926-ycdaw2vh 102 49 inoculated inoculate VBN cord-003926-ycdaw2vh 102 50 with with IN cord-003926-ycdaw2vh 102 51 sera sera NNP cord-003926-ycdaw2vh 102 52 from from IN cord-003926-ycdaw2vh 102 53 five five CD cord-003926-ycdaw2vh 102 54 ( ( -LRB- cord-003926-ycdaw2vh 102 55 50 50 CD cord-003926-ycdaw2vh 102 56 % % NN cord-003926-ycdaw2vh 102 57 ) ) -RRB- cord-003926-ycdaw2vh 102 58 individuals individual NNS cord-003926-ycdaw2vh 102 59 [ [ -LRB- cord-003926-ycdaw2vh 102 60 45 45 CD cord-003926-ycdaw2vh 102 61 ] ] -RRB- cord-003926-ycdaw2vh 102 62 . . . cord-003926-ycdaw2vh 103 1 Clinical clinical JJ cord-003926-ycdaw2vh 103 2 trial trial NN cord-003926-ycdaw2vh 103 3 data datum NNS cord-003926-ycdaw2vh 103 4 for for IN cord-003926-ycdaw2vh 103 5 the the DT cord-003926-ycdaw2vh 103 6 other other JJ cord-003926-ycdaw2vh 103 7 vaccines vaccine NNS cord-003926-ycdaw2vh 103 8 has have VBZ cord-003926-ycdaw2vh 103 9 not not RB cord-003926-ycdaw2vh 103 10 yet yet RB cord-003926-ycdaw2vh 103 11 been be VBN cord-003926-ycdaw2vh 103 12 reported report VBN cord-003926-ycdaw2vh 103 13 as as IN cord-003926-ycdaw2vh 103 14 of of IN cord-003926-ycdaw2vh 103 15 the the DT cord-003926-ycdaw2vh 103 16 date date NN cord-003926-ycdaw2vh 103 17 of of IN cord-003926-ycdaw2vh 103 18 this this DT cord-003926-ycdaw2vh 103 19 monograph monograph NN cord-003926-ycdaw2vh 103 20 , , , cord-003926-ycdaw2vh 103 21 however however RB cord-003926-ycdaw2vh 103 22 , , , cord-003926-ycdaw2vh 103 23 pre pre JJ cord-003926-ycdaw2vh 103 24 - - JJ cord-003926-ycdaw2vh 103 25 clinical clinical JJ cord-003926-ycdaw2vh 103 26 data datum NNS cord-003926-ycdaw2vh 103 27 has have VBZ cord-003926-ycdaw2vh 103 28 been be VBN cord-003926-ycdaw2vh 103 29 reported report VBN cord-003926-ycdaw2vh 103 30 for for IN cord-003926-ycdaw2vh 103 31 three three CD cord-003926-ycdaw2vh 103 32 candidate candidate NN cord-003926-ycdaw2vh 103 33 vaccines vaccine NNS cord-003926-ycdaw2vh 103 34 . . . cord-003926-ycdaw2vh 104 1 An an DT cord-003926-ycdaw2vh 104 2 mRNA mrna NN cord-003926-ycdaw2vh 104 3 vaccine vaccine NN cord-003926-ycdaw2vh 104 4 that that WDT cord-003926-ycdaw2vh 104 5 incorporates incorporate VBZ cord-003926-ycdaw2vh 104 6 the the DT cord-003926-ycdaw2vh 104 7 prM prm JJ cord-003926-ycdaw2vh 104 8 - - HYPH cord-003926-ycdaw2vh 104 9 E e NN cord-003926-ycdaw2vh 104 10 genes gene NNS cord-003926-ycdaw2vh 104 11 of of IN cord-003926-ycdaw2vh 104 12 a a DT cord-003926-ycdaw2vh 104 13 Micronesian micronesian JJ cord-003926-ycdaw2vh 104 14 strain strain NN cord-003926-ycdaw2vh 104 15 of of IN cord-003926-ycdaw2vh 104 16 Zika Zika NNP cord-003926-ycdaw2vh 104 17 virus virus NN cord-003926-ycdaw2vh 104 18 was be VBD cord-003926-ycdaw2vh 104 19 created create VBN cord-003926-ycdaw2vh 104 20 incorporating incorporate VBG cord-003926-ycdaw2vh 104 21 with with IN cord-003926-ycdaw2vh 104 22 or or CC cord-003926-ycdaw2vh 104 23 without without IN cord-003926-ycdaw2vh 104 24 four four CD cord-003926-ycdaw2vh 104 25 - - HYPH cord-003926-ycdaw2vh 104 26 point point NN cord-003926-ycdaw2vh 104 27 mutations mutation NNS cord-003926-ycdaw2vh 104 28 in in IN cord-003926-ycdaw2vh 104 29 the the DT cord-003926-ycdaw2vh 104 30 fusion fusion NN cord-003926-ycdaw2vh 104 31 - - HYPH cord-003926-ycdaw2vh 104 32 loop loop NN cord-003926-ycdaw2vh 104 33 segment segment NN cord-003926-ycdaw2vh 104 34 of of IN cord-003926-ycdaw2vh 104 35 the the DT cord-003926-ycdaw2vh 104 36 DII DII NNP cord-003926-ycdaw2vh 104 37 region region NN cord-003926-ycdaw2vh 104 38 of of IN cord-003926-ycdaw2vh 104 39 the the DT cord-003926-ycdaw2vh 104 40 envelope envelope NN cord-003926-ycdaw2vh 104 41 gene gene NN cord-003926-ycdaw2vh 104 42 that that WDT cord-003926-ycdaw2vh 104 43 abolished abolish VBD cord-003926-ycdaw2vh 104 44 binding binding NN cord-003926-ycdaw2vh 104 45 of of IN cord-003926-ycdaw2vh 104 46 antibodies antibody NNS cord-003926-ycdaw2vh 104 47 directed direct VBN cord-003926-ycdaw2vh 104 48 against against IN cord-003926-ycdaw2vh 104 49 the the DT cord-003926-ycdaw2vh 104 50 fusion fusion NN cord-003926-ycdaw2vh 104 51 - - HYPH cord-003926-ycdaw2vh 104 52 loop loop NN cord-003926-ycdaw2vh 104 53 region region NN cord-003926-ycdaw2vh 104 54 to to TO cord-003926-ycdaw2vh 104 55 reduce reduce VB cord-003926-ycdaw2vh 104 56 the the DT cord-003926-ycdaw2vh 104 57 potential potential JJ cord-003926-ycdaw2vh 104 58 risk risk NN cord-003926-ycdaw2vh 104 59 for for IN cord-003926-ycdaw2vh 104 60 antibody antibody NN cord-003926-ycdaw2vh 104 61 - - HYPH cord-003926-ycdaw2vh 104 62 dependent dependent JJ cord-003926-ycdaw2vh 104 63 enhancement enhancement NN cord-003926-ycdaw2vh 104 64 of of IN cord-003926-ycdaw2vh 104 65 infection infection NN cord-003926-ycdaw2vh 104 66 [ [ -LRB- cord-003926-ycdaw2vh 104 67 48 48 CD cord-003926-ycdaw2vh 104 68 ] ] -RRB- cord-003926-ycdaw2vh 104 69 . . . cord-003926-ycdaw2vh 105 1 Immunization Immunization NNP cord-003926-ycdaw2vh 105 2 of of IN cord-003926-ycdaw2vh 105 3 AG129 AG129 NNP cord-003926-ycdaw2vh 105 4 mice mouse NNS cord-003926-ycdaw2vh 105 5 with with IN cord-003926-ycdaw2vh 105 6 un un NNP cord-003926-ycdaw2vh 105 7 - - JJ cord-003926-ycdaw2vh 105 8 modified modify VBN cord-003926-ycdaw2vh 105 9 lipid lipid NN cord-003926-ycdaw2vh 105 10 nanoparticle nanoparticle NN cord-003926-ycdaw2vh 105 11 - - HYPH cord-003926-ycdaw2vh 105 12 encapsulated encapsulate VBN cord-003926-ycdaw2vh 105 13 vaccines vaccine NNS cord-003926-ycdaw2vh 105 14 mRNA mrna NN cord-003926-ycdaw2vh 105 15 was be VBD cord-003926-ycdaw2vh 105 16 immunogenic immunogenic JJ cord-003926-ycdaw2vh 105 17 and and CC cord-003926-ycdaw2vh 105 18 protective protective JJ cord-003926-ycdaw2vh 105 19 against against IN cord-003926-ycdaw2vh 105 20 lethal lethal JJ cord-003926-ycdaw2vh 105 21 infection infection NN cord-003926-ycdaw2vh 105 22 ; ; : cord-003926-ycdaw2vh 105 23 immunization immunization NN cord-003926-ycdaw2vh 105 24 of of IN cord-003926-ycdaw2vh 105 25 C57BL/6 C57BL/6 NNP cord-003926-ycdaw2vh 105 26 immunocompetent immunocompetent JJ cord-003926-ycdaw2vh 105 27 mice mouse NNS cord-003926-ycdaw2vh 105 28 followed follow VBN cord-003926-ycdaw2vh 105 29 by by IN cord-003926-ycdaw2vh 105 30 treatment treatment NN cord-003926-ycdaw2vh 105 31 with with IN cord-003926-ycdaw2vh 105 32 anti anti JJ cord-003926-ycdaw2vh 105 33 - - JJ cord-003926-ycdaw2vh 105 34 ifnar1 ifnar1 JJ cord-003926-ycdaw2vh 105 35 blocking block VBG cord-003926-ycdaw2vh 105 36 antibody antibody NN cord-003926-ycdaw2vh 105 37 showed show VBD cord-003926-ycdaw2vh 105 38 protection protection NN cord-003926-ycdaw2vh 105 39 against against IN cord-003926-ycdaw2vh 105 40 viremia viremia NN cord-003926-ycdaw2vh 105 41 in in IN cord-003926-ycdaw2vh 105 42 approximately approximately RB cord-003926-ycdaw2vh 105 43 60 60 CD cord-003926-ycdaw2vh 105 44 % % NN cord-003926-ycdaw2vh 105 45 of of IN cord-003926-ycdaw2vh 105 46 animals animal NNS cord-003926-ycdaw2vh 105 47 [ [ -LRB- cord-003926-ycdaw2vh 105 48 48 48 CD cord-003926-ycdaw2vh 105 49 ] ] -RRB- cord-003926-ycdaw2vh 105 50 . . . cord-003926-ycdaw2vh 106 1 PIZV PIZV NNP cord-003926-ycdaw2vh 106 2 , , , cord-003926-ycdaw2vh 106 3 an an DT cord-003926-ycdaw2vh 106 4 inactivated inactivate VBN cord-003926-ycdaw2vh 106 5 vaccine vaccine NN cord-003926-ycdaw2vh 106 6 derived derive VBN cord-003926-ycdaw2vh 106 7 from from IN cord-003926-ycdaw2vh 106 8 Puerto puerto JJ cord-003926-ycdaw2vh 106 9 Rican rican JJ cord-003926-ycdaw2vh 106 10 strain strain NN cord-003926-ycdaw2vh 106 11 PRVABC59 PRVABC59 NNP cord-003926-ycdaw2vh 106 12 selected select VBN cord-003926-ycdaw2vh 106 13 as as IN cord-003926-ycdaw2vh 106 14 without without IN cord-003926-ycdaw2vh 106 15 passage passage NN cord-003926-ycdaw2vh 106 16 - - HYPH cord-003926-ycdaw2vh 106 17 related relate VBN cord-003926-ycdaw2vh 106 18 mutations mutation NNS cord-003926-ycdaw2vh 106 19 , , , cord-003926-ycdaw2vh 106 20 protected protect VBN cord-003926-ycdaw2vh 106 21 against against IN cord-003926-ycdaw2vh 106 22 lethal lethal JJ cord-003926-ycdaw2vh 106 23 Zika Zika NNP cord-003926-ycdaw2vh 106 24 virus virus NN cord-003926-ycdaw2vh 106 25 challenge challenge NN cord-003926-ycdaw2vh 106 26 in in IN cord-003926-ycdaw2vh 106 27 AG129 AG129 NNP cord-003926-ycdaw2vh 106 28 mice mouse NNS cord-003926-ycdaw2vh 106 29 when when WRB cord-003926-ycdaw2vh 106 30 administered administer VBN cord-003926-ycdaw2vh 106 31 with with IN cord-003926-ycdaw2vh 106 32 alum alum NN cord-003926-ycdaw2vh 106 33 adjuvant adjuvant JJ cord-003926-ycdaw2vh 106 34 [ [ -LRB- cord-003926-ycdaw2vh 106 35 49 49 CD cord-003926-ycdaw2vh 106 36 ] ] -RRB- cord-003926-ycdaw2vh 106 37 . . . cord-003926-ycdaw2vh 107 1 A a DT cord-003926-ycdaw2vh 107 2 measles measles NN cord-003926-ycdaw2vh 107 3 - - HYPH cord-003926-ycdaw2vh 107 4 vectored vectore VBN cord-003926-ycdaw2vh 107 5 vaccine vaccine NN cord-003926-ycdaw2vh 107 6 encoding encode VBG cord-003926-ycdaw2vh 107 7 the the DT cord-003926-ycdaw2vh 107 8 Zika Zika NNP cord-003926-ycdaw2vh 107 9 virus virus NN cord-003926-ycdaw2vh 107 10 prME prME NNS cord-003926-ycdaw2vh 107 11 was be VBD cord-003926-ycdaw2vh 107 12 shown show VBN cord-003926-ycdaw2vh 107 13 to to TO cord-003926-ycdaw2vh 107 14 lessen lessen VB cord-003926-ycdaw2vh 107 15 viremia viremia NN cord-003926-ycdaw2vh 107 16 in in IN cord-003926-ycdaw2vh 107 17 pregnant pregnant JJ cord-003926-ycdaw2vh 107 18 IFNAR IFNAR NNP cord-003926-ycdaw2vh 107 19 mice mouse NNS cord-003926-ycdaw2vh 107 20 and and CC cord-003926-ycdaw2vh 107 21 prevented prevent VBD cord-003926-ycdaw2vh 107 22 clinical clinical JJ cord-003926-ycdaw2vh 107 23 disease disease NN cord-003926-ycdaw2vh 107 24 in in IN cord-003926-ycdaw2vh 107 25 mouse mouse NN cord-003926-ycdaw2vh 107 26 pups pup NNS cord-003926-ycdaw2vh 107 27 [ [ -LRB- cord-003926-ycdaw2vh 107 28 50 50 CD cord-003926-ycdaw2vh 107 29 ] ] -RRB- cord-003926-ycdaw2vh 107 30 . . . cord-003926-ycdaw2vh 108 1 Preclinical preclinical JJ cord-003926-ycdaw2vh 108 2 data datum NNS cord-003926-ycdaw2vh 108 3 for for IN cord-003926-ycdaw2vh 108 4 VLA-1601 VLA-1601 NNS cord-003926-ycdaw2vh 108 5 inactivated inactivate VBD cord-003926-ycdaw2vh 108 6 viral viral JJ cord-003926-ycdaw2vh 108 7 vaccines vaccine NNS cord-003926-ycdaw2vh 108 8 and and CC cord-003926-ycdaw2vh 108 9 the the DT cord-003926-ycdaw2vh 108 10 rZIKV rZIKV NNP cord-003926-ycdaw2vh 108 11 / / SYM cord-003926-ycdaw2vh 108 12 D4∆30 D4∆30 NNP cord-003926-ycdaw2vh 108 13 - - HYPH cord-003926-ycdaw2vh 108 14 713 713 CD cord-003926-ycdaw2vh 108 15 live live JJ cord-003926-ycdaw2vh 108 16 virus virus NN cord-003926-ycdaw2vh 108 17 vaccine vaccine NN cord-003926-ycdaw2vh 108 18 has have VBZ cord-003926-ycdaw2vh 108 19 not not RB cord-003926-ycdaw2vh 108 20 yet yet RB cord-003926-ycdaw2vh 108 21 been be VBN cord-003926-ycdaw2vh 108 22 reported report VBN cord-003926-ycdaw2vh 108 23 . . . cord-003926-ycdaw2vh 109 1 A a DT cord-003926-ycdaw2vh 109 2 number number NN cord-003926-ycdaw2vh 109 3 of of IN cord-003926-ycdaw2vh 109 4 animal animal NN cord-003926-ycdaw2vh 109 5 models model NNS cord-003926-ycdaw2vh 109 6 have have VBP cord-003926-ycdaw2vh 109 7 been be VBN cord-003926-ycdaw2vh 109 8 assessed assess VBN cord-003926-ycdaw2vh 109 9 for for IN cord-003926-ycdaw2vh 109 10 vaccine vaccine NN cord-003926-ycdaw2vh 109 11 development development NN cord-003926-ycdaw2vh 109 12 and and CC cord-003926-ycdaw2vh 109 13 have have VBP cord-003926-ycdaw2vh 109 14 been be VBN cord-003926-ycdaw2vh 109 15 reviewed review VBN cord-003926-ycdaw2vh 109 16 elsewhere elsewhere RB cord-003926-ycdaw2vh 109 17 [ [ -LRB- cord-003926-ycdaw2vh 109 18 51 51 CD cord-003926-ycdaw2vh 109 19 ] ] -RRB- cord-003926-ycdaw2vh 109 20 . . . cord-003926-ycdaw2vh 110 1 Immunocompetent immunocompetent NN cord-003926-ycdaw2vh 110 2 mice mouse NNS cord-003926-ycdaw2vh 110 3 can can MD cord-003926-ycdaw2vh 110 4 develop develop VB cord-003926-ycdaw2vh 110 5 transient transient JJ cord-003926-ycdaw2vh 110 6 viremia viremia NN cord-003926-ycdaw2vh 110 7 following follow VBG cord-003926-ycdaw2vh 110 8 infection infection NN cord-003926-ycdaw2vh 110 9 and and CC cord-003926-ycdaw2vh 110 10 may may MD cord-003926-ycdaw2vh 110 11 represent represent VB cord-003926-ycdaw2vh 110 12 models model NNS cord-003926-ycdaw2vh 110 13 to to TO cord-003926-ycdaw2vh 110 14 test test VB cord-003926-ycdaw2vh 110 15 sterilizing sterilize VBG cord-003926-ycdaw2vh 110 16 immunity immunity NN cord-003926-ycdaw2vh 110 17 . . . cord-003926-ycdaw2vh 111 1 Interferon interferon NN cord-003926-ycdaw2vh 111 2 α α NNP cord-003926-ycdaw2vh 111 3 / / SYM cord-003926-ycdaw2vh 111 4 β β NN cord-003926-ycdaw2vh 111 5 receptor receptor NN cord-003926-ycdaw2vh 111 6 knockout knockout NN cord-003926-ycdaw2vh 111 7 mice mouse NNS cord-003926-ycdaw2vh 112 1 ( ( -LRB- cord-003926-ycdaw2vh 112 2 AG129 AG129 NNP cord-003926-ycdaw2vh 112 3 or or CC cord-003926-ycdaw2vh 112 4 IFNAR IFNAR NNP cord-003926-ycdaw2vh 112 5 -/- -/- ADD cord-003926-ycdaw2vh 112 6 ) ) -RRB- cord-003926-ycdaw2vh 112 7 develop develop VB cord-003926-ycdaw2vh 112 8 lethal lethal JJ cord-003926-ycdaw2vh 112 9 infection infection NN cord-003926-ycdaw2vh 112 10 following follow VBG cord-003926-ycdaw2vh 112 11 Zika Zika NNP cord-003926-ycdaw2vh 112 12 virus virus NN cord-003926-ycdaw2vh 112 13 infection infection NN cord-003926-ycdaw2vh 112 14 and and CC cord-003926-ycdaw2vh 112 15 have have VBP cord-003926-ycdaw2vh 112 16 been be VBN cord-003926-ycdaw2vh 112 17 used use VBN cord-003926-ycdaw2vh 112 18 as as IN cord-003926-ycdaw2vh 112 19 a a DT cord-003926-ycdaw2vh 112 20 more more RBR cord-003926-ycdaw2vh 112 21 stringent stringent JJ cord-003926-ycdaw2vh 112 22 measure measure NN cord-003926-ycdaw2vh 112 23 of of IN cord-003926-ycdaw2vh 112 24 protection protection NN cord-003926-ycdaw2vh 112 25 . . . cord-003926-ycdaw2vh 113 1 Non non JJ cord-003926-ycdaw2vh 113 2 - - JJ cord-003926-ycdaw2vh 113 3 human human JJ cord-003926-ycdaw2vh 113 4 primates primate NNS cord-003926-ycdaw2vh 113 5 develop develop VBP cord-003926-ycdaw2vh 113 6 a a DT cord-003926-ycdaw2vh 113 7 self self NN cord-003926-ycdaw2vh 113 8 - - HYPH cord-003926-ycdaw2vh 113 9 limited limit VBN cord-003926-ycdaw2vh 113 10 mild mild JJ cord-003926-ycdaw2vh 113 11 illness illness NN cord-003926-ycdaw2vh 113 12 associated associate VBN cord-003926-ycdaw2vh 113 13 with with IN cord-003926-ycdaw2vh 113 14 viremia viremia NN cord-003926-ycdaw2vh 113 15 and and CC cord-003926-ycdaw2vh 113 16 can can MD cord-003926-ycdaw2vh 113 17 transmit transmit VB cord-003926-ycdaw2vh 113 18 virus virus NN cord-003926-ycdaw2vh 113 19 in in IN cord-003926-ycdaw2vh 113 20 utero utero NNS cord-003926-ycdaw2vh 113 21 to to IN cord-003926-ycdaw2vh 113 22 primate primate JJ cord-003926-ycdaw2vh 113 23 fetus fetus NN cord-003926-ycdaw2vh 113 24 [ [ -LRB- cord-003926-ycdaw2vh 113 25 52 52 CD cord-003926-ycdaw2vh 113 26 ] ] -RRB- cord-003926-ycdaw2vh 113 27 . . . cord-003926-ycdaw2vh 114 1 The the DT cord-003926-ycdaw2vh 114 2 logistical logistical JJ cord-003926-ycdaw2vh 114 3 difficulties difficulty NNS cord-003926-ycdaw2vh 114 4 in in IN cord-003926-ycdaw2vh 114 5 pursuing pursue VBG cord-003926-ycdaw2vh 114 6 standard standard JJ cord-003926-ycdaw2vh 114 7 vaccine vaccine NN cord-003926-ycdaw2vh 114 8 evaluation evaluation NN cord-003926-ycdaw2vh 114 9 have have VBP cord-003926-ycdaw2vh 114 10 created create VBN cord-003926-ycdaw2vh 114 11 significant significant JJ cord-003926-ycdaw2vh 114 12 interest interest NN cord-003926-ycdaw2vh 114 13 in in IN cord-003926-ycdaw2vh 114 14 the the DT cord-003926-ycdaw2vh 114 15 possibility possibility NN cord-003926-ycdaw2vh 114 16 of of IN cord-003926-ycdaw2vh 114 17 controlled control VBN cord-003926-ycdaw2vh 114 18 human human JJ cord-003926-ycdaw2vh 114 19 infection infection NN cord-003926-ycdaw2vh 114 20 models model NNS cord-003926-ycdaw2vh 114 21 ( ( -LRB- cord-003926-ycdaw2vh 114 22 CHIM CHIM NNP cord-003926-ycdaw2vh 114 23 ) ) -RRB- cord-003926-ycdaw2vh 114 24 . . . cord-003926-ycdaw2vh 115 1 The the DT cord-003926-ycdaw2vh 115 2 conduct conduct NN cord-003926-ycdaw2vh 115 3 and and CC cord-003926-ycdaw2vh 115 4 planning plan VBG cord-003926-ycdaw2vh 115 5 for for IN cord-003926-ycdaw2vh 115 6 human human JJ cord-003926-ycdaw2vh 115 7 challenge challenge NN cord-003926-ycdaw2vh 115 8 trials trial NNS cord-003926-ycdaw2vh 115 9 raises raise VBZ cord-003926-ycdaw2vh 115 10 unique unique JJ cord-003926-ycdaw2vh 115 11 medical medical JJ cord-003926-ycdaw2vh 115 12 and and CC cord-003926-ycdaw2vh 115 13 ethical ethical JJ cord-003926-ycdaw2vh 115 14 considerations consideration NNS cord-003926-ycdaw2vh 115 15 . . . cord-003926-ycdaw2vh 116 1 For for IN cord-003926-ycdaw2vh 116 2 Zika Zika NNP cord-003926-ycdaw2vh 116 3 virus virus NN cord-003926-ycdaw2vh 116 4 trials trial NNS cord-003926-ycdaw2vh 116 5 , , , cord-003926-ycdaw2vh 116 6 one one PRP cord-003926-ycdaw2vh 116 7 must must MD cord-003926-ycdaw2vh 116 8 balance balance VB cord-003926-ycdaw2vh 116 9 the the DT cord-003926-ycdaw2vh 116 10 relative relative JJ cord-003926-ycdaw2vh 116 11 benign benign JJ cord-003926-ycdaw2vh 116 12 and and CC cord-003926-ycdaw2vh 116 13 self self NN cord-003926-ycdaw2vh 116 14 - - HYPH cord-003926-ycdaw2vh 116 15 limited limit VBN cord-003926-ycdaw2vh 116 16 infection infection NN cord-003926-ycdaw2vh 116 17 experienced experience VBN cord-003926-ycdaw2vh 116 18 by by IN cord-003926-ycdaw2vh 116 19 the the DT cord-003926-ycdaw2vh 116 20 vast vast JJ cord-003926-ycdaw2vh 116 21 majority majority NN cord-003926-ycdaw2vh 116 22 against against IN cord-003926-ycdaw2vh 116 23 the the DT cord-003926-ycdaw2vh 116 24 risk risk NN cord-003926-ycdaw2vh 116 25 for for IN cord-003926-ycdaw2vh 116 26 less less RBR cord-003926-ycdaw2vh 116 27 benign benign JJ cord-003926-ycdaw2vh 116 28 complications complication NNS cord-003926-ycdaw2vh 116 29 and and CC cord-003926-ycdaw2vh 116 30 transmission transmission NN cord-003926-ycdaw2vh 116 31 risks risk NNS cord-003926-ycdaw2vh 116 32 . . . cord-003926-ycdaw2vh 117 1 As as IN cord-003926-ycdaw2vh 117 2 reviewed review VBN cord-003926-ycdaw2vh 117 3 above above RB cord-003926-ycdaw2vh 117 4 , , , cord-003926-ycdaw2vh 117 5 published publish VBN cord-003926-ycdaw2vh 117 6 studies study NNS cord-003926-ycdaw2vh 117 7 provide provide VBP cord-003926-ycdaw2vh 117 8 estimates estimate NNS cord-003926-ycdaw2vh 117 9 that that IN cord-003926-ycdaw2vh 117 10 Zika Zika NNP cord-003926-ycdaw2vh 117 11 virus virus NN cord-003926-ycdaw2vh 117 12 infection infection NN cord-003926-ycdaw2vh 117 13 is be VBZ cord-003926-ycdaw2vh 117 14 relatively relatively RB cord-003926-ycdaw2vh 117 15 asymptomatic asymptomatic JJ cord-003926-ycdaw2vh 117 16 and and CC cord-003926-ycdaw2vh 117 17 self self NN cord-003926-ycdaw2vh 117 18 - - HYPH cord-003926-ycdaw2vh 117 19 limited limit VBN cord-003926-ycdaw2vh 117 20 for for IN cord-003926-ycdaw2vh 117 21 the the DT cord-003926-ycdaw2vh 117 22 majority majority NN cord-003926-ycdaw2vh 117 23 of of IN cord-003926-ycdaw2vh 117 24 individuals individual NNS cord-003926-ycdaw2vh 117 25 , , , cord-003926-ycdaw2vh 117 26 however however RB cord-003926-ycdaw2vh 117 27 , , , cord-003926-ycdaw2vh 117 28 methodology methodology NN cord-003926-ycdaw2vh 117 29 in in IN cord-003926-ycdaw2vh 117 30 these these DT cord-003926-ycdaw2vh 117 31 studies study NNS cord-003926-ycdaw2vh 117 32 varies vary VBZ cord-003926-ycdaw2vh 117 33 widely widely RB cord-003926-ycdaw2vh 117 34 . . . cord-003926-ycdaw2vh 118 1 In in IN cord-003926-ycdaw2vh 118 2 adults adult NNS cord-003926-ycdaw2vh 118 3 , , , cord-003926-ycdaw2vh 118 4 two two CD cord-003926-ycdaw2vh 118 5 sets set NNS cord-003926-ycdaw2vh 118 6 of of IN cord-003926-ycdaw2vh 118 7 complications complication NNS cord-003926-ycdaw2vh 118 8 warrant warrant VBP cord-003926-ycdaw2vh 118 9 consideration consideration NN cord-003926-ycdaw2vh 118 10 for for IN cord-003926-ycdaw2vh 118 11 a a DT cord-003926-ycdaw2vh 118 12 proposed propose VBN cord-003926-ycdaw2vh 118 13 CHIM CHIM NNP cord-003926-ycdaw2vh 118 14 study study NN cord-003926-ycdaw2vh 118 15 . . . cord-003926-ycdaw2vh 119 1 As as IN cord-003926-ycdaw2vh 119 2 reviewed review VBN cord-003926-ycdaw2vh 119 3 above above RB cord-003926-ycdaw2vh 119 4 , , , cord-003926-ycdaw2vh 119 5 a a DT cord-003926-ycdaw2vh 119 6 Guillain Guillain NNP cord-003926-ycdaw2vh 119 7 - - HYPH cord-003926-ycdaw2vh 119 8 Barre Barre NNP cord-003926-ycdaw2vh 119 9 - - HYPH cord-003926-ycdaw2vh 119 10 like like JJ cord-003926-ycdaw2vh 119 11 syndrome syndrome NN cord-003926-ycdaw2vh 119 12 occurs occur VBZ cord-003926-ycdaw2vh 119 13 in in IN cord-003926-ycdaw2vh 119 14 approximately approximately RB cord-003926-ycdaw2vh 119 15 1 1 CD cord-003926-ycdaw2vh 119 16 of of IN cord-003926-ycdaw2vh 119 17 5000 5000 CD cord-003926-ycdaw2vh 119 18 Zika Zika NNP cord-003926-ycdaw2vh 119 19 virus virus NN cord-003926-ycdaw2vh 119 20 infections infection NNS cord-003926-ycdaw2vh 119 21 [ [ -LRB- cord-003926-ycdaw2vh 119 22 13 13 CD cord-003926-ycdaw2vh 119 23 ] ] -RRB- cord-003926-ycdaw2vh 119 24 , , , cord-003926-ycdaw2vh 119 25 whereas whereas IN cord-003926-ycdaw2vh 119 26 other other JJ cord-003926-ycdaw2vh 119 27 neurologic neurologic JJ cord-003926-ycdaw2vh 119 28 complications complication NNS cord-003926-ycdaw2vh 119 29 such such JJ cord-003926-ycdaw2vh 119 30 as as IN cord-003926-ycdaw2vh 119 31 meningoencephalitis meningoencephalitis NNP cord-003926-ycdaw2vh 119 32 , , , cord-003926-ycdaw2vh 119 33 myelitis myelitis NNP cord-003926-ycdaw2vh 119 34 [ [ -LRB- cord-003926-ycdaw2vh 119 35 15 15 CD cord-003926-ycdaw2vh 119 36 , , , cord-003926-ycdaw2vh 119 37 53 53 CD cord-003926-ycdaw2vh 119 38 , , , cord-003926-ycdaw2vh 119 39 54 54 CD cord-003926-ycdaw2vh 119 40 ] ] -RRB- cord-003926-ycdaw2vh 119 41 , , , cord-003926-ycdaw2vh 119 42 and and CC cord-003926-ycdaw2vh 119 43 acute acute JJ cord-003926-ycdaw2vh 119 44 disseminated disseminate VBN cord-003926-ycdaw2vh 119 45 encephalomyelitis encephalomyelitis NN cord-003926-ycdaw2vh 119 46 [ [ -LRB- cord-003926-ycdaw2vh 119 47 54 54 CD cord-003926-ycdaw2vh 119 48 ] ] -RRB- cord-003926-ycdaw2vh 119 49 are be VBP cord-003926-ycdaw2vh 119 50 rare rare JJ cord-003926-ycdaw2vh 119 51 . . . cord-003926-ycdaw2vh 120 1 Second second JJ cord-003926-ycdaw2vh 120 2 , , , cord-003926-ycdaw2vh 120 3 and and CC cord-003926-ycdaw2vh 120 4 perhaps perhaps RB cord-003926-ycdaw2vh 120 5 more more RBR cord-003926-ycdaw2vh 120 6 important important JJ cord-003926-ycdaw2vh 120 7 , , , cord-003926-ycdaw2vh 120 8 is be VBZ cord-003926-ycdaw2vh 120 9 the the DT cord-003926-ycdaw2vh 120 10 risk risk NN cord-003926-ycdaw2vh 120 11 of of IN cord-003926-ycdaw2vh 120 12 transmission transmission NN cord-003926-ycdaw2vh 120 13 to to IN cord-003926-ycdaw2vh 120 14 a a DT cord-003926-ycdaw2vh 120 15 sexual sexual JJ cord-003926-ycdaw2vh 120 16 partner partner NN cord-003926-ycdaw2vh 120 17 and and CC cord-003926-ycdaw2vh 120 18 the the DT cord-003926-ycdaw2vh 120 19 potential potential NN cord-003926-ycdaw2vh 120 20 for for IN cord-003926-ycdaw2vh 120 21 infection infection NN cord-003926-ycdaw2vh 120 22 during during IN cord-003926-ycdaw2vh 120 23 pregnancy pregnancy NN cord-003926-ycdaw2vh 120 24 . . . cord-003926-ycdaw2vh 121 1 Zika Zika NNP cord-003926-ycdaw2vh 121 2 virus virus NN cord-003926-ycdaw2vh 121 3 commonly commonly RB cord-003926-ycdaw2vh 121 4 persists persist VBZ cord-003926-ycdaw2vh 121 5 in in IN cord-003926-ycdaw2vh 121 6 the the DT cord-003926-ycdaw2vh 121 7 male male JJ cord-003926-ycdaw2vh 121 8 urogenital urogenital JJ cord-003926-ycdaw2vh 121 9 tract tract NN cord-003926-ycdaw2vh 121 10 for for IN cord-003926-ycdaw2vh 121 11 3 3 CD cord-003926-ycdaw2vh 121 12 months month NNS cord-003926-ycdaw2vh 121 13 , , , cord-003926-ycdaw2vh 121 14 and and CC cord-003926-ycdaw2vh 121 15 may may MD cord-003926-ycdaw2vh 121 16 persist persist VB cord-003926-ycdaw2vh 121 17 in in IN cord-003926-ycdaw2vh 121 18 some some DT cord-003926-ycdaw2vh 121 19 individuals individual NNS cord-003926-ycdaw2vh 121 20 for for IN cord-003926-ycdaw2vh 121 21 up up IN cord-003926-ycdaw2vh 121 22 to to TO cord-003926-ycdaw2vh 121 23 8 8 CD cord-003926-ycdaw2vh 121 24 months month NNS cord-003926-ycdaw2vh 121 25 [ [ -LRB- cord-003926-ycdaw2vh 121 26 27 27 CD cord-003926-ycdaw2vh 121 27 ] ] -RRB- cord-003926-ycdaw2vh 121 28 . . . cord-003926-ycdaw2vh 122 1 Some some DT cord-003926-ycdaw2vh 122 2 have have VBP cord-003926-ycdaw2vh 122 3 considered consider VBN cord-003926-ycdaw2vh 122 4 limiting limit VBG cord-003926-ycdaw2vh 122 5 studies study NNS cord-003926-ycdaw2vh 122 6 to to IN cord-003926-ycdaw2vh 122 7 non non JJ cord-003926-ycdaw2vh 122 8 - - JJ cord-003926-ycdaw2vh 122 9 pregnant pregnant JJ cord-003926-ycdaw2vh 122 10 females female NNS cord-003926-ycdaw2vh 122 11 as as IN cord-003926-ycdaw2vh 122 12 Zika Zika NNP cord-003926-ycdaw2vh 122 13 virus virus NN cord-003926-ycdaw2vh 122 14 colonization colonization NN cord-003926-ycdaw2vh 122 15 of of IN cord-003926-ycdaw2vh 122 16 the the DT cord-003926-ycdaw2vh 122 17 female female JJ cord-003926-ycdaw2vh 122 18 genital genital JJ cord-003926-ycdaw2vh 122 19 tract tract NN cord-003926-ycdaw2vh 122 20 may may MD cord-003926-ycdaw2vh 122 21 be be VB cord-003926-ycdaw2vh 122 22 temporally temporally RB cord-003926-ycdaw2vh 122 23 limited limited JJ cord-003926-ycdaw2vh 122 24 . . . cord-003926-ycdaw2vh 123 1 The the DT cord-003926-ycdaw2vh 123 2 fact fact NN cord-003926-ycdaw2vh 123 3 that that IN cord-003926-ycdaw2vh 123 4 Zika Zika NNP cord-003926-ycdaw2vh 123 5 virus virus NN cord-003926-ycdaw2vh 123 6 is be VBZ cord-003926-ycdaw2vh 123 7 known know VBN cord-003926-ycdaw2vh 123 8 to to TO cord-003926-ycdaw2vh 123 9 cause cause VB cord-003926-ycdaw2vh 123 10 testicular testicular JJ cord-003926-ycdaw2vh 123 11 atrophy atrophy NN cord-003926-ycdaw2vh 123 12 in in IN cord-003926-ycdaw2vh 123 13 mice mouse NNS cord-003926-ycdaw2vh 123 14 [ [ -LRB- cord-003926-ycdaw2vh 123 15 28 28 CD cord-003926-ycdaw2vh 123 16 ] ] -RRB- cord-003926-ycdaw2vh 123 17 [ [ -LRB- cord-003926-ycdaw2vh 123 18 29 29 CD cord-003926-ycdaw2vh 123 19 ] ] -RRB- cord-003926-ycdaw2vh 123 20 [ [ -LRB- cord-003926-ycdaw2vh 123 21 30 30 CD cord-003926-ycdaw2vh 123 22 ] ] -RRB- cord-003926-ycdaw2vh 123 23 , , , cord-003926-ycdaw2vh 123 24 raises raise VBZ cord-003926-ycdaw2vh 123 25 yet yet RB cord-003926-ycdaw2vh 123 26 another another DT cord-003926-ycdaw2vh 123 27 as as RB cord-003926-ycdaw2vh 123 28 yet yet RB cord-003926-ycdaw2vh 123 29 theoretical theoretical JJ cord-003926-ycdaw2vh 123 30 concern concern NN cord-003926-ycdaw2vh 123 31 for for IN cord-003926-ycdaw2vh 123 32 humans human NNS cord-003926-ycdaw2vh 123 33 . . . cord-003926-ycdaw2vh 124 1 These these DT cord-003926-ycdaw2vh 124 2 questions question NNS cord-003926-ycdaw2vh 124 3 as as RB cord-003926-ycdaw2vh 124 4 well well RB cord-003926-ycdaw2vh 124 5 as as IN cord-003926-ycdaw2vh 124 6 the the DT cord-003926-ycdaw2vh 124 7 theoretical theoretical JJ cord-003926-ycdaw2vh 124 8 potential potential NN cord-003926-ycdaw2vh 124 9 for for IN cord-003926-ycdaw2vh 124 10 vector vector NN cord-003926-ycdaw2vh 124 11 - - HYPH cord-003926-ycdaw2vh 124 12 borne bear VBN cord-003926-ycdaw2vh 124 13 transmission transmission NN cord-003926-ycdaw2vh 124 14 were be VBD cord-003926-ycdaw2vh 124 15 debated debate VBN cord-003926-ycdaw2vh 124 16 in in IN cord-003926-ycdaw2vh 124 17 detail detail NN cord-003926-ycdaw2vh 124 18 in in IN cord-003926-ycdaw2vh 124 19 late late JJ cord-003926-ycdaw2vh 124 20 2016 2016 CD cord-003926-ycdaw2vh 124 21 with with IN cord-003926-ycdaw2vh 124 22 the the DT cord-003926-ycdaw2vh 124 23 conclusion conclusion NN cord-003926-ycdaw2vh 124 24 that that IN cord-003926-ycdaw2vh 124 25 the the DT cord-003926-ycdaw2vh 124 26 benefits benefit NNS cord-003926-ycdaw2vh 124 27 of of IN cord-003926-ycdaw2vh 124 28 a a DT cord-003926-ycdaw2vh 124 29 human human JJ cord-003926-ycdaw2vh 124 30 challenge challenge NN cord-003926-ycdaw2vh 124 31 infection infection NN cord-003926-ycdaw2vh 124 32 did do VBD cord-003926-ycdaw2vh 124 33 not not RB cord-003926-ycdaw2vh 124 34 outweigh outweigh VB cord-003926-ycdaw2vh 124 35 the the DT cord-003926-ycdaw2vh 124 36 risks risk NNS cord-003926-ycdaw2vh 124 37 [ [ -LRB- cord-003926-ycdaw2vh 124 38 55 55 CD cord-003926-ycdaw2vh 124 39 ] ] -RRB- cord-003926-ycdaw2vh 124 40 , , , cord-003926-ycdaw2vh 124 41 however however RB cord-003926-ycdaw2vh 124 42 , , , cord-003926-ycdaw2vh 124 43 this this DT cord-003926-ycdaw2vh 124 44 analysis analysis NN cord-003926-ycdaw2vh 124 45 was be VBD cord-003926-ycdaw2vh 124 46 performed perform VBN cord-003926-ycdaw2vh 124 47 just just RB cord-003926-ycdaw2vh 124 48 as as IN cord-003926-ycdaw2vh 124 49 the the DT cord-003926-ycdaw2vh 124 50 initial initial JJ cord-003926-ycdaw2vh 124 51 epidemic epidemic NN cord-003926-ycdaw2vh 124 52 wave wave NN cord-003926-ycdaw2vh 124 53 in in IN cord-003926-ycdaw2vh 124 54 the the DT cord-003926-ycdaw2vh 124 55 Americas Americas NNPS cord-003926-ycdaw2vh 124 56 was be VBD cord-003926-ycdaw2vh 124 57 ending end VBG cord-003926-ycdaw2vh 124 58 . . . cord-003926-ycdaw2vh 125 1 The the DT cord-003926-ycdaw2vh 125 2 group group NN cord-003926-ycdaw2vh 125 3 published publish VBD cord-003926-ycdaw2vh 125 4 a a DT cord-003926-ycdaw2vh 125 5 follow follow NN cord-003926-ycdaw2vh 125 6 - - HYPH cord-003926-ycdaw2vh 125 7 up up NN cord-003926-ycdaw2vh 125 8 in in IN cord-003926-ycdaw2vh 125 9 2018 2018 CD cord-003926-ycdaw2vh 125 10 [ [ -LRB- cord-003926-ycdaw2vh 125 11 56 56 CD cord-003926-ycdaw2vh 125 12 ] ] -RRB- cord-003926-ycdaw2vh 125 13 . . . cord-003926-ycdaw2vh 126 1 Despite despite IN cord-003926-ycdaw2vh 126 2 the the DT cord-003926-ycdaw2vh 126 3 recognition recognition NN cord-003926-ycdaw2vh 126 4 that that IN cord-003926-ycdaw2vh 126 5 conducting conduct VBG cord-003926-ycdaw2vh 126 6 a a DT cord-003926-ycdaw2vh 126 7 placebo placebo NN cord-003926-ycdaw2vh 126 8 - - HYPH cord-003926-ycdaw2vh 126 9 controlled control VBN cord-003926-ycdaw2vh 126 10 vaccine vaccine NN cord-003926-ycdaw2vh 126 11 trial trial NN cord-003926-ycdaw2vh 126 12 had have VBD cord-003926-ycdaw2vh 126 13 become become VBN cord-003926-ycdaw2vh 126 14 significantly significantly RB cord-003926-ycdaw2vh 126 15 more more RBR cord-003926-ycdaw2vh 126 16 difficult difficult JJ cord-003926-ycdaw2vh 126 17 due due IN cord-003926-ycdaw2vh 126 18 to to IN cord-003926-ycdaw2vh 126 19 declining decline VBG cord-003926-ycdaw2vh 126 20 case case NN cord-003926-ycdaw2vh 126 21 rates rate NNS cord-003926-ycdaw2vh 126 22 , , , cord-003926-ycdaw2vh 126 23 the the DT cord-003926-ycdaw2vh 126 24 group group NN cord-003926-ycdaw2vh 126 25 's 's POS cord-003926-ycdaw2vh 126 26 conclusion conclusion NN cord-003926-ycdaw2vh 126 27 was be VBD cord-003926-ycdaw2vh 126 28 essentially essentially RB cord-003926-ycdaw2vh 126 29 unchanged unchanged JJ cord-003926-ycdaw2vh 126 30 . . . cord-003926-ycdaw2vh 127 1 To to TO cord-003926-ycdaw2vh 127 2 address address VB cord-003926-ycdaw2vh 127 3 safety safety NN cord-003926-ycdaw2vh 127 4 concerns concern NNS cord-003926-ycdaw2vh 127 5 , , , cord-003926-ycdaw2vh 127 6 there there EX cord-003926-ycdaw2vh 127 7 has have VBZ cord-003926-ycdaw2vh 127 8 been be VBN cord-003926-ycdaw2vh 127 9 work work NN cord-003926-ycdaw2vh 127 10 to to TO cord-003926-ycdaw2vh 127 11 develop develop VB cord-003926-ycdaw2vh 127 12 attenuated attenuated JJ cord-003926-ycdaw2vh 127 13 viral viral JJ cord-003926-ycdaw2vh 127 14 strains strain NNS cord-003926-ycdaw2vh 127 15 deleted delete VBN cord-003926-ycdaw2vh 127 16 for for IN cord-003926-ycdaw2vh 127 17 potential potential JJ cord-003926-ycdaw2vh 127 18 neurotropic neurotropic JJ cord-003926-ycdaw2vh 127 19 regions region NNS cord-003926-ycdaw2vh 127 20 [ [ -LRB- cord-003926-ycdaw2vh 127 21 57 57 CD cord-003926-ycdaw2vh 127 22 ] ] -RRB- cord-003926-ycdaw2vh 127 23 with with IN cord-003926-ycdaw2vh 127 24 a a DT cord-003926-ycdaw2vh 127 25 goal goal NN cord-003926-ycdaw2vh 127 26 to to TO cord-003926-ycdaw2vh 127 27 prevent prevent VB cord-003926-ycdaw2vh 127 28 viremia viremia NN cord-003926-ycdaw2vh 127 29 . . . cord-003926-ycdaw2vh 128 1 Whether whether IN cord-003926-ycdaw2vh 128 2 the the DT cord-003926-ycdaw2vh 128 3 attenuated attenuated JJ cord-003926-ycdaw2vh 128 4 viral viral JJ cord-003926-ycdaw2vh 128 5 strain strain NN cord-003926-ycdaw2vh 128 6 ( ( -LRB- cord-003926-ycdaw2vh 128 7 rZIKV rZIKV NNP cord-003926-ycdaw2vh 128 8 / / SYM cord-003926-ycdaw2vh 128 9 D4∆30 D4∆30 NNP cord-003926-ycdaw2vh 128 10 - - HYPH cord-003926-ycdaw2vh 128 11 713 713 CD cord-003926-ycdaw2vh 128 12 ) ) -RRB- cord-003926-ycdaw2vh 128 13 being be VBG cord-003926-ycdaw2vh 128 14 tested test VBN cord-003926-ycdaw2vh 128 15 in in IN cord-003926-ycdaw2vh 128 16 a a DT cord-003926-ycdaw2vh 128 17 Phase phase NN cord-003926-ycdaw2vh 128 18 I -PRON- PRP cord-003926-ycdaw2vh 128 19 study study NN cord-003926-ycdaw2vh 128 20 will will MD cord-003926-ycdaw2vh 128 21 serve serve VB cord-003926-ycdaw2vh 128 22 as as IN cord-003926-ycdaw2vh 128 23 putative putative JJ cord-003926-ycdaw2vh 128 24 challenge challenge NN cord-003926-ycdaw2vh 128 25 strain strain NN cord-003926-ycdaw2vh 128 26 is be VBZ cord-003926-ycdaw2vh 128 27 as as RB cord-003926-ycdaw2vh 128 28 yet yet RB cord-003926-ycdaw2vh 128 29 undetermined undetermined JJ cord-003926-ycdaw2vh 128 30 . . . cord-003926-ycdaw2vh 129 1 In in IN cord-003926-ycdaw2vh 129 2 summary summary NN cord-003926-ycdaw2vh 129 3 , , , cord-003926-ycdaw2vh 129 4 Zika Zika NNP cord-003926-ycdaw2vh 129 5 vaccine vaccine NN cord-003926-ycdaw2vh 129 6 development development NN cord-003926-ycdaw2vh 129 7 continues continue VBZ cord-003926-ycdaw2vh 129 8 with with IN cord-003926-ycdaw2vh 129 9 multiple multiple JJ cord-003926-ycdaw2vh 129 10 candidate candidate NN cord-003926-ycdaw2vh 129 11 vaccines vaccine NNS cord-003926-ycdaw2vh 129 12 in in IN cord-003926-ycdaw2vh 129 13 clinical clinical JJ cord-003926-ycdaw2vh 129 14 trials trial NNS cord-003926-ycdaw2vh 129 15 . . . cord-003926-ycdaw2vh 130 1 Because because IN cord-003926-ycdaw2vh 130 2 of of IN cord-003926-ycdaw2vh 130 3 the the DT cord-003926-ycdaw2vh 130 4 significant significant JJ cord-003926-ycdaw2vh 130 5 decline decline NN cord-003926-ycdaw2vh 130 6 in in IN cord-003926-ycdaw2vh 130 7 incidence incidence NN cord-003926-ycdaw2vh 130 8 , , , cord-003926-ycdaw2vh 130 9 evaluation evaluation NN cord-003926-ycdaw2vh 130 10 of of IN cord-003926-ycdaw2vh 130 11 vaccine vaccine NN cord-003926-ycdaw2vh 130 12 efficacy efficacy NN cord-003926-ycdaw2vh 130 13 is be VBZ cord-003926-ycdaw2vh 130 14 increasingly increasingly RB cord-003926-ycdaw2vh 130 15 difficult difficult JJ cord-003926-ycdaw2vh 130 16 . . . cord-003926-ycdaw2vh 131 1 There there EX cord-003926-ycdaw2vh 131 2 has have VBZ cord-003926-ycdaw2vh 131 3 been be VBN cord-003926-ycdaw2vh 131 4 renewed renew VBN cord-003926-ycdaw2vh 131 5 interest interest NN cord-003926-ycdaw2vh 131 6 in in IN cord-003926-ycdaw2vh 131 7 animal animal NN cord-003926-ycdaw2vh 131 8 model model NN cord-003926-ycdaw2vh 131 9 and and CC cord-003926-ycdaw2vh 131 10 human human JJ cord-003926-ycdaw2vh 131 11 infection infection NN cord-003926-ycdaw2vh 131 12 models model NNS cord-003926-ycdaw2vh 131 13 of of IN cord-003926-ycdaw2vh 131 14 infection infection NN cord-003926-ycdaw2vh 131 15 . . . cord-003926-ycdaw2vh 131 16 _SP cord-003926-ycdaw2vh 132 1 The the DT cord-003926-ycdaw2vh 132 2 author author NN cord-003926-ycdaw2vh 132 3 is be VBZ cord-003926-ycdaw2vh 132 4 an an DT cord-003926-ycdaw2vh 132 5 employee employee NN cord-003926-ycdaw2vh 132 6 of of IN cord-003926-ycdaw2vh 132 7 GeneOne GeneOne NNP cord-003926-ycdaw2vh 132 8 Life Life NNP cord-003926-ycdaw2vh 132 9 Science Science NNP cord-003926-ycdaw2vh 132 10 , , , cord-003926-ycdaw2vh 132 11 Inc. Inc. NNP cord-003926-ycdaw2vh 132 12 , , , cord-003926-ycdaw2vh 132 13 a a DT cord-003926-ycdaw2vh 132 14 developer developer NN cord-003926-ycdaw2vh 132 15 of of IN cord-003926-ycdaw2vh 132 16 DNA dna NN cord-003926-ycdaw2vh 132 17 - - HYPH cord-003926-ycdaw2vh 132 18 based base VBN cord-003926-ycdaw2vh 132 19 vaccines vaccine NNS cord-003926-ycdaw2vh 132 20 including include VBG cord-003926-ycdaw2vh 132 21 a a DT cord-003926-ycdaw2vh 132 22 vaccine vaccine NN cord-003926-ycdaw2vh 132 23 against against IN cord-003926-ycdaw2vh 132 24 the the DT cord-003926-ycdaw2vh 132 25 Zika Zika NNP cord-003926-ycdaw2vh 132 26 virus virus NN cord-003926-ycdaw2vh 132 27 . . . cord-003926-ycdaw2vh 133 1 Walter Walter NNP cord-003926-ycdaw2vh 133 2 Reed Reed NNP cord-003926-ycdaw2vh 133 3 Army Army NNP cord-003926-ycdaw2vh 133 4 Institute Institute NNP cord-003926-ycdaw2vh 133 5 of of IN cord-003926-ycdaw2vh 133 6 Research Research NNP cord-003926-ycdaw2vh 133 7 NIAID NIAID NNP cord-003926-ycdaw2vh 133 8 National National NNP cord-003926-ycdaw2vh 133 9 Institutes Institutes NNPS cord-003926-ycdaw2vh 133 10 of of IN cord-003926-ycdaw2vh 133 11 Allergy Allergy NNP cord-003926-ycdaw2vh 133 12 and and CC cord-003926-ycdaw2vh 133 13 Infectious Infectious NNP cord-003926-ycdaw2vh 133 14 Disease Disease NNP cord-003926-ycdaw2vh 134 1 VRC VRC NNP cord-003926-ycdaw2vh 134 2 Vaccine Vaccine NNP cord-003926-ycdaw2vh 134 3 Research Research NNP cord-003926-ycdaw2vh 134 4 Center Center NNP cord-003926-ycdaw2vh 134 5 Zika Zika NNP cord-003926-ycdaw2vh 134 6 virus virus NN cord-003926-ycdaw2vh 134 7 : : : cord-003926-ycdaw2vh 134 8 ( ( -LRB- cord-003926-ycdaw2vh 134 9 I i NN cord-003926-ycdaw2vh 134 10 ) ) -RRB- cord-003926-ycdaw2vh 134 11 . . . cord-003926-ycdaw2vh 135 1 Isolations isolation NNS cord-003926-ycdaw2vh 135 2 and and CC cord-003926-ycdaw2vh 135 3 serological serological JJ cord-003926-ycdaw2vh 135 4 specificity specificity NN cord-003926-ycdaw2vh 135 5 Zika Zika NNP cord-003926-ycdaw2vh 135 6 virus virus NN cord-003926-ycdaw2vh 135 7 : : : cord-003926-ycdaw2vh 135 8 Following follow VBG cord-003926-ycdaw2vh 135 9 the the DT cord-003926-ycdaw2vh 135 10 path path NN cord-003926-ycdaw2vh 135 11 of of IN cord-003926-ycdaw2vh 135 12 dengue dengue NN cord-003926-ycdaw2vh 135 13 and and CC cord-003926-ycdaw2vh 135 14 chikungunya chikungunya NN cord-003926-ycdaw2vh 135 15 ? ? . cord-003926-ycdaw2vh 136 1 Lancet Lancet NNP cord-003926-ycdaw2vh 136 2 Zika Zika NNP cord-003926-ycdaw2vh 136 3 virus virus NN cord-003926-ycdaw2vh 136 4 outbreak outbreak NN cord-003926-ycdaw2vh 136 5 on on IN cord-003926-ycdaw2vh 136 6 Yap Yap NNP cord-003926-ycdaw2vh 136 7 Island Island NNP cord-003926-ycdaw2vh 136 8 , , , cord-003926-ycdaw2vh 136 9 Federated Federated NNP cord-003926-ycdaw2vh 136 10 States States NNP cord-003926-ycdaw2vh 136 11 of of IN cord-003926-ycdaw2vh 136 12 Micronesia Micronesia NNP cord-003926-ycdaw2vh 136 13 European European NNP cord-003926-ycdaw2vh 136 14 Centre Centre NNP cord-003926-ycdaw2vh 136 15 for for IN cord-003926-ycdaw2vh 136 16 Disease Disease NNP cord-003926-ycdaw2vh 136 17 Prevention Prevention NNP cord-003926-ycdaw2vh 136 18 and and CC cord-003926-ycdaw2vh 136 19 Control Control NNP cord-003926-ycdaw2vh 136 20 . . . cord-003926-ycdaw2vh 137 1 Rapid rapid JJ cord-003926-ycdaw2vh 137 2 risk risk NN cord-003926-ycdaw2vh 137 3 assessment assessment NN cord-003926-ycdaw2vh 137 4 : : : cord-003926-ycdaw2vh 138 1 Zika Zika NNP cord-003926-ycdaw2vh 138 2 virus virus NN cord-003926-ycdaw2vh 138 3 infection infection NN cord-003926-ycdaw2vh 138 4 outbreak outbreak NN cord-003926-ycdaw2vh 138 5 , , , cord-003926-ycdaw2vh 138 6 French French NNP cord-003926-ycdaw2vh 138 7 Polynesia Polynesia NNP cord-003926-ycdaw2vh 138 8 Zika Zika NNP cord-003926-ycdaw2vh 138 9 virus virus NN cord-003926-ycdaw2vh 138 10 in in IN cord-003926-ycdaw2vh 138 11 the the DT cord-003926-ycdaw2vh 138 12 Americas- Americas- NNP cord-003926-ycdaw2vh 139 1 Yet yet RB cord-003926-ycdaw2vh 139 2 another another DT cord-003926-ycdaw2vh 139 3 arbovirus arbovirus NN cord-003926-ycdaw2vh 139 4 threat threat NN cord-003926-ycdaw2vh 139 5 Steep Steep NNP cord-003926-ycdaw2vh 139 6 drop drop NN cord-003926-ycdaw2vh 139 7 in in IN cord-003926-ycdaw2vh 139 8 Zika Zika NNP cord-003926-ycdaw2vh 139 9 cases case NNS cord-003926-ycdaw2vh 139 10 undermines undermine VBZ cord-003926-ycdaw2vh 139 11 vaccine vaccine NN cord-003926-ycdaw2vh 139 12 trial trial NN cord-003926-ycdaw2vh 139 13 Demonstrating demonstrate VBG cord-003926-ycdaw2vh 139 14 vaccine vaccine NN cord-003926-ycdaw2vh 139 15 effectiveness effectiveness NN cord-003926-ycdaw2vh 139 16 during during IN cord-003926-ycdaw2vh 139 17 a a DT cord-003926-ycdaw2vh 139 18 waning wane VBG cord-003926-ycdaw2vh 139 19 epidemic epidemic NN cord-003926-ycdaw2vh 139 20 : : : cord-003926-ycdaw2vh 140 1 A a DT cord-003926-ycdaw2vh 140 2 WHO WHO NNP cord-003926-ycdaw2vh 140 3 / / SYM cord-003926-ycdaw2vh 140 4 NIH NIH NNP cord-003926-ycdaw2vh 140 5 meeting meeting NN cord-003926-ycdaw2vh 140 6 report report NN cord-003926-ycdaw2vh 140 7 on on IN cord-003926-ycdaw2vh 140 8 approaches approach NNS cord-003926-ycdaw2vh 140 9 to to IN cord-003926-ycdaw2vh 140 10 development development NN cord-003926-ycdaw2vh 140 11 and and CC cord-003926-ycdaw2vh 140 12 licensure licensure NN cord-003926-ycdaw2vh 140 13 of of IN cord-003926-ycdaw2vh 140 14 Zika Zika NNP cord-003926-ycdaw2vh 140 15 vaccine vaccine NN cord-003926-ycdaw2vh 140 16 candidates candidate NNS cord-003926-ycdaw2vh 140 17 Bilan Bilan NNP cord-003926-ycdaw2vh 140 18 de de NNP cord-003926-ycdaw2vh 140 19 l'épidémie l'épidémie NNP cord-003926-ycdaw2vh 140 20 à à , cord-003926-ycdaw2vh 140 21 virus virus NN cord-003926-ycdaw2vh 140 22 Zika Zika NNP cord-003926-ycdaw2vh 140 23 survenue survenue NNP cord-003926-ycdaw2vh 140 24 en en IN cord-003926-ycdaw2vh 140 25 Polynésie Polynésie NNP cord-003926-ycdaw2vh 140 26 française française NNP cord-003926-ycdaw2vh 140 27 entre entre FW cord-003926-ycdaw2vh 140 28 octobre octobre NNP cord-003926-ycdaw2vh 140 29 2013 2013 CD cord-003926-ycdaw2vh 141 1 et et NNP cord-003926-ycdaw2vh 141 2 mars mars NNP cord-003926-ycdaw2vh 141 3 2014 2014 CD cord-003926-ycdaw2vh 141 4 . . . cord-003926-ycdaw2vh 142 1 De De NNP cord-003926-ycdaw2vh 142 2 la la NNP cord-003926-ycdaw2vh 142 3 description description NN cord-003926-ycdaw2vh 142 4 de de FW cord-003926-ycdaw2vh 142 5 l'épidémie l'épidémie NNP cord-003926-ycdaw2vh 142 6 aux aux NNP cord-003926-ycdaw2vh 142 7 connaissances connaissances NNP cord-003926-ycdaw2vh 142 8 acquises acquises NNP cord-003926-ycdaw2vh 142 9 après après NNP cord-003926-ycdaw2vh 142 10 l'évènement l'évènement NNP cord-003926-ycdaw2vh 142 11 Potential Potential NNP cord-003926-ycdaw2vh 142 12 for for IN cord-003926-ycdaw2vh 142 13 Zika Zika NNP cord-003926-ycdaw2vh 142 14 virus virus NN cord-003926-ycdaw2vh 142 15 transmission transmission NN cord-003926-ycdaw2vh 142 16 through through IN cord-003926-ycdaw2vh 142 17 blood blood NN cord-003926-ycdaw2vh 142 18 transfusion transfusion NN cord-003926-ycdaw2vh 142 19 demonstrated demonstrate VBD cord-003926-ycdaw2vh 142 20 during during IN cord-003926-ycdaw2vh 142 21 an an DT cord-003926-ycdaw2vh 142 22 outbreak outbreak NN cord-003926-ycdaw2vh 142 23 in in IN cord-003926-ycdaw2vh 142 24 French French NNP cord-003926-ycdaw2vh 142 25 Polynesia Polynesia NNP cord-003926-ycdaw2vh 142 26 Zika Zika NNP cord-003926-ycdaw2vh 142 27 virus virus NN cord-003926-ycdaw2vh 142 28 seroprevalence seroprevalence NN cord-003926-ycdaw2vh 142 29 Prevalence prevalence NN cord-003926-ycdaw2vh 142 30 of of IN cord-003926-ycdaw2vh 142 31 asymptomatic asymptomatic JJ cord-003926-ycdaw2vh 142 32 Zika Zika NNP cord-003926-ycdaw2vh 142 33 virus virus NN cord-003926-ycdaw2vh 142 34 infection infection NN cord-003926-ycdaw2vh 142 35 : : : cord-003926-ycdaw2vh 142 36 A a DT cord-003926-ycdaw2vh 142 37 systematic systematic JJ cord-003926-ycdaw2vh 142 38 review review NN cord-003926-ycdaw2vh 142 39 Guillain Guillain NNP cord-003926-ycdaw2vh 142 40 - - HYPH cord-003926-ycdaw2vh 142 41 Barre Barre NNP cord-003926-ycdaw2vh 142 42 Syndrome Syndrome NNP cord-003926-ycdaw2vh 142 43 outbreak outbreak NN cord-003926-ycdaw2vh 142 44 associated associate VBN cord-003926-ycdaw2vh 142 45 with with IN cord-003926-ycdaw2vh 142 46 Zika Zika NNP cord-003926-ycdaw2vh 142 47 virus virus NN cord-003926-ycdaw2vh 142 48 infection infection NN cord-003926-ycdaw2vh 142 49 in in IN cord-003926-ycdaw2vh 142 50 French French NNP cord-003926-ycdaw2vh 142 51 Polynesia Polynesia NNP cord-003926-ycdaw2vh 142 52 : : : cord-003926-ycdaw2vh 143 1 A a DT cord-003926-ycdaw2vh 143 2 case case NN cord-003926-ycdaw2vh 143 3 - - HYPH cord-003926-ycdaw2vh 143 4 control control NN cord-003926-ycdaw2vh 143 5 study study NN cord-003926-ycdaw2vh 143 6 Zika Zika NNP cord-003926-ycdaw2vh 143 7 virus virus NN cord-003926-ycdaw2vh 143 8 infection infection NN cord-003926-ycdaw2vh 143 9 and and CC cord-003926-ycdaw2vh 143 10 risk risk NN cord-003926-ycdaw2vh 143 11 of of IN cord-003926-ycdaw2vh 143 12 Guillain Guillain NNP cord-003926-ycdaw2vh 143 13 - - HYPH cord-003926-ycdaw2vh 143 14 Barre Barre NNP cord-003926-ycdaw2vh 143 15 syndrome syndrome NN cord-003926-ycdaw2vh 143 16 : : : cord-003926-ycdaw2vh 143 17 A a DT cord-003926-ycdaw2vh 143 18 meta meta JJ cord-003926-ycdaw2vh 143 19 - - HYPH cord-003926-ycdaw2vh 143 20 analysis analysis NN cord-003926-ycdaw2vh 143 21 Leparc Leparc NNP cord-003926-ycdaw2vh 143 22 - - HYPH cord-003926-ycdaw2vh 143 23 Goffart Goffart NNP cord-003926-ycdaw2vh 143 24 , , , cord-003926-ycdaw2vh 143 25 I. I. NNP cord-003926-ycdaw2vh 143 26 ; ; : cord-003926-ycdaw2vh 143 27 et et NNP cord-003926-ycdaw2vh 143 28 al al NNP cord-003926-ycdaw2vh 143 29 . . . cord-003926-ycdaw2vh 144 1 Zika Zika NNP cord-003926-ycdaw2vh 144 2 virus virus NN cord-003926-ycdaw2vh 144 3 associated associate VBN cord-003926-ycdaw2vh 144 4 with with IN cord-003926-ycdaw2vh 144 5 meningoencephalitis meningoencephalitis NNP cord-003926-ycdaw2vh 144 6 Congenital congenital JJ cord-003926-ycdaw2vh 144 7 cerebral cerebral JJ cord-003926-ycdaw2vh 144 8 malformations malformation NNS cord-003926-ycdaw2vh 144 9 and and CC cord-003926-ycdaw2vh 144 10 dysfunction dysfunction NN cord-003926-ycdaw2vh 144 11 in in IN cord-003926-ycdaw2vh 144 12 fetuses fetus NNS cord-003926-ycdaw2vh 144 13 and and CC cord-003926-ycdaw2vh 144 14 newborns newborn NNS cord-003926-ycdaw2vh 144 15 following follow VBG cord-003926-ycdaw2vh 144 16 the the DT cord-003926-ycdaw2vh 144 17 2013 2013 CD cord-003926-ycdaw2vh 144 18 to to IN cord-003926-ycdaw2vh 144 19 2014 2014 CD cord-003926-ycdaw2vh 144 20 Zika Zika NNP cord-003926-ycdaw2vh 144 21 virus virus NN cord-003926-ycdaw2vh 144 22 epidemic epidemic NN cord-003926-ycdaw2vh 144 23 in in IN cord-003926-ycdaw2vh 144 24 French French NNP cord-003926-ycdaw2vh 144 25 Polynesia Polynesia NNP cord-003926-ycdaw2vh 144 26 Zika Zika NNP cord-003926-ycdaw2vh 144 27 virus virus NN cord-003926-ycdaw2vh 144 28 infection infection NN cord-003926-ycdaw2vh 144 29 in in IN cord-003926-ycdaw2vh 144 30 pregnant pregnant JJ cord-003926-ycdaw2vh 144 31 women woman NNS cord-003926-ycdaw2vh 144 32 in in IN cord-003926-ycdaw2vh 144 33 Rio Rio NNP cord-003926-ycdaw2vh 144 34 de de NNP cord-003926-ycdaw2vh 144 35 Janeiro Janeiro NNP cord-003926-ycdaw2vh 144 36 European European NNP cord-003926-ycdaw2vh 144 37 Centre Centre NNP cord-003926-ycdaw2vh 144 38 for for IN cord-003926-ycdaw2vh 144 39 Disease Disease NNP cord-003926-ycdaw2vh 144 40 Prevention Prevention NNP cord-003926-ycdaw2vh 144 41 and and CC cord-003926-ycdaw2vh 144 42 Control Control NNP cord-003926-ycdaw2vh 144 43 . . . cord-003926-ycdaw2vh 145 1 Rapid rapid JJ cord-003926-ycdaw2vh 145 2 risk risk NN cord-003926-ycdaw2vh 145 3 assessment assessment NN cord-003926-ycdaw2vh 145 4 : : : cord-003926-ycdaw2vh 146 1 Zika Zika NNP cord-003926-ycdaw2vh 146 2 virus virus NN cord-003926-ycdaw2vh 146 3 epidemic epidemic NN cord-003926-ycdaw2vh 146 4 in in IN cord-003926-ycdaw2vh 146 5 the the DT cord-003926-ycdaw2vh 146 6 Americas Americas NNPS cord-003926-ycdaw2vh 146 7 : : : cord-003926-ycdaw2vh 146 8 Potential potential JJ cord-003926-ycdaw2vh 146 9 association association NN cord-003926-ycdaw2vh 146 10 with with IN cord-003926-ycdaw2vh 146 11 microcephaly microcephaly NNS cord-003926-ycdaw2vh 146 12 and and CC cord-003926-ycdaw2vh 146 13 Guillain Guillain NNP cord-003926-ycdaw2vh 146 14 - - HYPH cord-003926-ycdaw2vh 146 15 Barre Barre NNP cord-003926-ycdaw2vh 146 16 syndrome syndrome NN cord-003926-ycdaw2vh 146 17 Birth birth NN cord-003926-ycdaw2vh 146 18 defects defect NNS cord-003926-ycdaw2vh 146 19 among among IN cord-003926-ycdaw2vh 146 20 fetuses fetus NNS cord-003926-ycdaw2vh 146 21 and and CC cord-003926-ycdaw2vh 146 22 infants infant NNS cord-003926-ycdaw2vh 146 23 of of IN cord-003926-ycdaw2vh 146 24 US US NNP cord-003926-ycdaw2vh 146 25 women woman NNS cord-003926-ycdaw2vh 146 26 with with IN cord-003926-ycdaw2vh 146 27 evidence evidence NN cord-003926-ycdaw2vh 146 28 of of IN cord-003926-ycdaw2vh 146 29 possible possible JJ cord-003926-ycdaw2vh 146 30 Zika Zika NNP cord-003926-ycdaw2vh 146 31 virus virus NN cord-003926-ycdaw2vh 146 32 infection infection NN cord-003926-ycdaw2vh 146 33 during during IN cord-003926-ycdaw2vh 146 34 pregnancy pregnancy NN cord-003926-ycdaw2vh 146 35 Hearing hear VBG cord-003926-ycdaw2vh 146 36 loss loss NN cord-003926-ycdaw2vh 146 37 in in IN cord-003926-ycdaw2vh 146 38 infants infant NNS cord-003926-ycdaw2vh 146 39 with with IN cord-003926-ycdaw2vh 146 40 microcephaly microcephaly NNS cord-003926-ycdaw2vh 146 41 and and CC cord-003926-ycdaw2vh 146 42 evidence evidence NN cord-003926-ycdaw2vh 146 43 of of IN cord-003926-ycdaw2vh 146 44 congenital congenital JJ cord-003926-ycdaw2vh 146 45 Zika Zika NNP cord-003926-ycdaw2vh 146 46 virus virus NN cord-003926-ycdaw2vh 146 47 infection infection NN cord-003926-ycdaw2vh 146 48 - - : cord-003926-ycdaw2vh 146 49 Brazil Brazil NNP cord-003926-ycdaw2vh 146 50 Risk risk NN cord-003926-ycdaw2vh 146 51 factors factor NNS cord-003926-ycdaw2vh 146 52 associated associate VBN cord-003926-ycdaw2vh 146 53 with with IN cord-003926-ycdaw2vh 146 54 the the DT cord-003926-ycdaw2vh 146 55 ophthalmoscopic ophthalmoscopic NNP cord-003926-ycdaw2vh 146 56 findings finding NNS cord-003926-ycdaw2vh 146 57 identifed identife VBN cord-003926-ycdaw2vh 146 58 in in IN cord-003926-ycdaw2vh 146 59 infants infant NNS cord-003926-ycdaw2vh 146 60 with with IN cord-003926-ycdaw2vh 146 61 presumed presume VBN cord-003926-ycdaw2vh 146 62 Zika Zika NNP cord-003926-ycdaw2vh 146 63 virus virus NN cord-003926-ycdaw2vh 146 64 congenital congenital JJ cord-003926-ycdaw2vh 146 65 infection infection NN cord-003926-ycdaw2vh 146 66 Zika Zika NNP cord-003926-ycdaw2vh 146 67 virus virus NN cord-003926-ycdaw2vh 146 68 infection infection NN cord-003926-ycdaw2vh 146 69 with with IN cord-003926-ycdaw2vh 146 70 prolonged prolong VBN cord-003926-ycdaw2vh 146 71 maternal maternal JJ cord-003926-ycdaw2vh 146 72 viremia viremia NN cord-003926-ycdaw2vh 146 73 and and CC cord-003926-ycdaw2vh 146 74 fetal fetal JJ cord-003926-ycdaw2vh 146 75 brain brain NN cord-003926-ycdaw2vh 146 76 abnormalities abnormality NNS cord-003926-ycdaw2vh 146 77 Prolonged prolong VBD cord-003926-ycdaw2vh 146 78 detection detection NN cord-003926-ycdaw2vh 146 79 of of IN cord-003926-ycdaw2vh 146 80 Zika Zika NNP cord-003926-ycdaw2vh 146 81 virus virus NN cord-003926-ycdaw2vh 146 82 RNA RNA NNP cord-003926-ycdaw2vh 146 83 in in IN cord-003926-ycdaw2vh 146 84 pregnant pregnant JJ cord-003926-ycdaw2vh 146 85 women woman NNS cord-003926-ycdaw2vh 146 86 Zika Zika NNP cord-003926-ycdaw2vh 146 87 virus virus NN cord-003926-ycdaw2vh 146 88 intrauterine intrauterine JJ cord-003926-ycdaw2vh 146 89 infection infection NN cord-003926-ycdaw2vh 146 90 causes cause VBZ cord-003926-ycdaw2vh 146 91 fetal fetal JJ cord-003926-ycdaw2vh 146 92 brain brain NN cord-003926-ycdaw2vh 146 93 abnormality abnormality NN cord-003926-ycdaw2vh 146 94 and and CC cord-003926-ycdaw2vh 146 95 microcephaly microcephaly NNS cord-003926-ycdaw2vh 146 96 : : : cord-003926-ycdaw2vh 147 1 Tip tip NN cord-003926-ycdaw2vh 147 2 of of IN cord-003926-ycdaw2vh 147 3 the the DT cord-003926-ycdaw2vh 147 4 iceberg iceberg NN cord-003926-ycdaw2vh 147 5 ? ? . cord-003926-ycdaw2vh 148 1 Probable probable JJ cord-003926-ycdaw2vh 148 2 non non JJ cord-003926-ycdaw2vh 148 3 - - JJ cord-003926-ycdaw2vh 148 4 vector vector NN cord-003926-ycdaw2vh 148 5 - - HYPH cord-003926-ycdaw2vh 148 6 borne bear VBN cord-003926-ycdaw2vh 148 7 transmission transmission NN cord-003926-ycdaw2vh 148 8 of of IN cord-003926-ycdaw2vh 148 9 Zika Zika NNP cord-003926-ycdaw2vh 148 10 virus virus NN cord-003926-ycdaw2vh 148 11 Frequent Frequent NNP cord-003926-ycdaw2vh 148 12 Zika Zika NNP cord-003926-ycdaw2vh 148 13 virus virus NN cord-003926-ycdaw2vh 148 14 sexual sexual JJ cord-003926-ycdaw2vh 148 15 transmission transmission NN cord-003926-ycdaw2vh 148 16 and and CC cord-003926-ycdaw2vh 148 17 prolonged prolong VBN cord-003926-ycdaw2vh 148 18 viral viral JJ cord-003926-ycdaw2vh 148 19 RNA rna NN cord-003926-ycdaw2vh 148 20 shedding shed VBG cord-003926-ycdaw2vh 148 21 in in IN cord-003926-ycdaw2vh 148 22 an an DT cord-003926-ycdaw2vh 148 23 immunodeficient immunodeficient JJ cord-003926-ycdaw2vh 148 24 mouse mouse NN cord-003926-ycdaw2vh 148 25 model model NN cord-003926-ycdaw2vh 148 26 Zika Zika NNP cord-003926-ycdaw2vh 148 27 virus virus NN cord-003926-ycdaw2vh 148 28 shedding shed VBG cord-003926-ycdaw2vh 148 29 in in IN cord-003926-ycdaw2vh 148 30 semen semen NN cord-003926-ycdaw2vh 148 31 of of IN cord-003926-ycdaw2vh 148 32 symptomatic symptomatic JJ cord-003926-ycdaw2vh 148 33 infected infected JJ cord-003926-ycdaw2vh 148 34 men man NNS cord-003926-ycdaw2vh 148 35 Zika Zika NNP cord-003926-ycdaw2vh 148 36 - - HYPH cord-003926-ycdaw2vh 148 37 induced induce VBN cord-003926-ycdaw2vh 148 38 male male JJ cord-003926-ycdaw2vh 148 39 infertility infertility NN cord-003926-ycdaw2vh 148 40 in in IN cord-003926-ycdaw2vh 148 41 mice mice NN cord-003926-ycdaw2vh 148 42 Is be VBZ cord-003926-ycdaw2vh 148 43 potentially potentially RB cord-003926-ycdaw2vh 148 44 reversible reversible JJ cord-003926-ycdaw2vh 148 45 and and CC cord-003926-ycdaw2vh 148 46 preventable preventable JJ cord-003926-ycdaw2vh 148 47 by by IN cord-003926-ycdaw2vh 148 48 deoxyribonucleic deoxyribonucleic NN cord-003926-ycdaw2vh 148 49 acid acid NN cord-003926-ycdaw2vh 148 50 immunization immunization NN cord-003926-ycdaw2vh 148 51 Zika Zika NNP cord-003926-ycdaw2vh 148 52 virus virus NN cord-003926-ycdaw2vh 148 53 infection infection NN cord-003926-ycdaw2vh 148 54 damages damage VBZ cord-003926-ycdaw2vh 148 55 the the DT cord-003926-ycdaw2vh 148 56 testes testis NNS cord-003926-ycdaw2vh 148 57 in in IN cord-003926-ycdaw2vh 148 58 mice mouse NNS cord-003926-ycdaw2vh 148 59 DNA dna NN cord-003926-ycdaw2vh 148 60 vaccination vaccination NN cord-003926-ycdaw2vh 148 61 protects protect VBZ cord-003926-ycdaw2vh 148 62 mice mouse NNS cord-003926-ycdaw2vh 148 63 against against IN cord-003926-ycdaw2vh 148 64 Zika Zika NNP cord-003926-ycdaw2vh 148 65 virus virus NN cord-003926-ycdaw2vh 148 66 - - HYPH cord-003926-ycdaw2vh 148 67 induced induce VBN cord-003926-ycdaw2vh 148 68 damage damage NN cord-003926-ycdaw2vh 148 69 to to IN cord-003926-ycdaw2vh 148 70 the the DT cord-003926-ycdaw2vh 148 71 testes testis NNS cord-003926-ycdaw2vh 149 1 Prolonged prolonged JJ cord-003926-ycdaw2vh 149 2 shedding shedding NN cord-003926-ycdaw2vh 149 3 of of IN cord-003926-ycdaw2vh 149 4 Zika Zika NNP cord-003926-ycdaw2vh 149 5 virus virus NN cord-003926-ycdaw2vh 149 6 RNA RNA NNP cord-003926-ycdaw2vh 149 7 in in IN cord-003926-ycdaw2vh 149 8 vaginal vaginal JJ cord-003926-ycdaw2vh 149 9 secretions secretion NNS cord-003926-ycdaw2vh 150 1 Zika Zika NNP cord-003926-ycdaw2vh 150 2 virus virus NN cord-003926-ycdaw2vh 150 3 causes cause VBZ cord-003926-ycdaw2vh 150 4 acute acute JJ cord-003926-ycdaw2vh 150 5 infection infection NN cord-003926-ycdaw2vh 150 6 and and CC cord-003926-ycdaw2vh 150 7 inflammation inflammation NN cord-003926-ycdaw2vh 150 8 in in IN cord-003926-ycdaw2vh 150 9 the the DT cord-003926-ycdaw2vh 150 10 ovary ovary NN cord-003926-ycdaw2vh 150 11 of of IN cord-003926-ycdaw2vh 150 12 mice mouse NNS cord-003926-ycdaw2vh 150 13 without without IN cord-003926-ycdaw2vh 150 14 apparent apparent JJ cord-003926-ycdaw2vh 150 15 defects defect NNS cord-003926-ycdaw2vh 150 16 in in IN cord-003926-ycdaw2vh 150 17 fertility fertility NN cord-003926-ycdaw2vh 150 18 Zika Zika NNP cord-003926-ycdaw2vh 150 19 virus virus NN cord-003926-ycdaw2vh 150 20 persistence persistence NN cord-003926-ycdaw2vh 150 21 in in IN cord-003926-ycdaw2vh 150 22 the the DT cord-003926-ycdaw2vh 150 23 central central JJ cord-003926-ycdaw2vh 150 24 nervous nervous JJ cord-003926-ycdaw2vh 150 25 system system NN cord-003926-ycdaw2vh 150 26 and and CC cord-003926-ycdaw2vh 150 27 lymph lymph NN cord-003926-ycdaw2vh 150 28 nodes node NNS cord-003926-ycdaw2vh 150 29 of of IN cord-003926-ycdaw2vh 150 30 rhesus rhesu NNS cord-003926-ycdaw2vh 150 31 monkeys monkey NNS cord-003926-ycdaw2vh 150 32 Vaccine Vaccine NNP cord-003926-ycdaw2vh 150 33 development development NN cord-003926-ycdaw2vh 150 34 for for IN cord-003926-ycdaw2vh 150 35 emerging emerge VBG cord-003926-ycdaw2vh 150 36 virulent virulent JJ cord-003926-ycdaw2vh 150 37 infectious infectious JJ cord-003926-ycdaw2vh 150 38 diseases disease NNS cord-003926-ycdaw2vh 150 39 Pan Pan NNP cord-003926-ycdaw2vh 150 40 American American NNP cord-003926-ycdaw2vh 150 41 Health Health NNP cord-003926-ycdaw2vh 150 42 Organization Organization NNP cord-003926-ycdaw2vh 150 43 / / SYM cord-003926-ycdaw2vh 150 44 World World NNP cord-003926-ycdaw2vh 150 45 Health Health NNP cord-003926-ycdaw2vh 150 46 Organization Organization NNP cord-003926-ycdaw2vh 150 47 . . . cord-003926-ycdaw2vh 151 1 Zika Zika NNP cord-003926-ycdaw2vh 151 2 - - HYPH cord-003926-ycdaw2vh 151 3 Epidemiologic Epidemiologic NNP cord-003926-ycdaw2vh 151 4 Report Report NNP cord-003926-ycdaw2vh 152 1 Brazil Brazil NNP cord-003926-ycdaw2vh 152 2 Comparison Comparison NNP cord-003926-ycdaw2vh 152 3 by by IN cord-003926-ycdaw2vh 152 4 electron electron NN cord-003926-ycdaw2vh 152 5 microscopy microscopy NNS cord-003926-ycdaw2vh 152 6 of of IN cord-003926-ycdaw2vh 152 7 the the DT cord-003926-ycdaw2vh 152 8 Ntaya Ntaya NNP cord-003926-ycdaw2vh 152 9 and and CC cord-003926-ycdaw2vh 152 10 Zika Zika NNP cord-003926-ycdaw2vh 152 11 viruses virus NNS cord-003926-ycdaw2vh 152 12 Development Development NNP cord-003926-ycdaw2vh 152 13 of of IN cord-003926-ycdaw2vh 152 14 vaccines vaccine NNS cord-003926-ycdaw2vh 152 15 against against IN cord-003926-ycdaw2vh 152 16 Zika Zika NNP cord-003926-ycdaw2vh 152 17 virus virus NN cord-003926-ycdaw2vh 152 18 Zika Zika NNP cord-003926-ycdaw2vh 152 19 virus virus NN cord-003926-ycdaw2vh 152 20 vaccine vaccine NN cord-003926-ycdaw2vh 152 21 development development NN cord-003926-ycdaw2vh 152 22 : : : cord-003926-ycdaw2vh 153 1 Progress progress VB cord-003926-ycdaw2vh 153 2 in in IN cord-003926-ycdaw2vh 153 3 the the DT cord-003926-ycdaw2vh 153 4 face face NN cord-003926-ycdaw2vh 153 5 of of IN cord-003926-ycdaw2vh 153 6 new new JJ cord-003926-ycdaw2vh 153 7 challenges challenge NNS cord-003926-ycdaw2vh 154 1 Vaccines vaccine NNS cord-003926-ycdaw2vh 154 2 for for IN cord-003926-ycdaw2vh 154 3 emerging emerge VBG cord-003926-ycdaw2vh 154 4 infectious infectious JJ cord-003926-ycdaw2vh 154 5 diseases disease NNS cord-003926-ycdaw2vh 154 6 : : : cord-003926-ycdaw2vh 154 7 Lessonso Lessonso NNS cord-003926-ycdaw2vh 154 8 from from IN cord-003926-ycdaw2vh 154 9 MERS MERS NNP cord-003926-ycdaw2vh 154 10 coronavirus coronavirus NN cord-003926-ycdaw2vh 154 11 and and CC cord-003926-ycdaw2vh 154 12 Zika Zika NNP cord-003926-ycdaw2vh 154 13 virus virus NN cord-003926-ycdaw2vh 155 1 An an DT cord-003926-ycdaw2vh 155 2 update update NN cord-003926-ycdaw2vh 155 3 on on IN cord-003926-ycdaw2vh 155 4 Zika Zika NNP cord-003926-ycdaw2vh 155 5 vaccine vaccine NN cord-003926-ycdaw2vh 155 6 developments development NNS cord-003926-ycdaw2vh 155 7 . . . cord-003926-ycdaw2vh 156 1 Expert Expert NNP cord-003926-ycdaw2vh 156 2 Rev Rev NNP cord-003926-ycdaw2vh 156 3 Safety Safety NNP cord-003926-ycdaw2vh 156 4 , , , cord-003926-ycdaw2vh 156 5 tolerability tolerability NN cord-003926-ycdaw2vh 156 6 , , , cord-003926-ycdaw2vh 156 7 and and CC cord-003926-ycdaw2vh 156 8 immunogenicity immunogenicity NN cord-003926-ycdaw2vh 156 9 of of IN cord-003926-ycdaw2vh 156 10 two two CD cord-003926-ycdaw2vh 156 11 Zika Zika NNP cord-003926-ycdaw2vh 156 12 virus virus NN cord-003926-ycdaw2vh 156 13 DNA dna NN cord-003926-ycdaw2vh 156 14 vaccine vaccine NN cord-003926-ycdaw2vh 156 15 candidates candidate NNS cord-003926-ycdaw2vh 156 16 in in IN cord-003926-ycdaw2vh 156 17 healthy healthy JJ cord-003926-ycdaw2vh 156 18 adults adult NNS cord-003926-ycdaw2vh 156 19 : : : cord-003926-ycdaw2vh 156 20 Randomised randomised JJ cord-003926-ycdaw2vh 156 21 , , , cord-003926-ycdaw2vh 156 22 open open JJ cord-003926-ycdaw2vh 156 23 - - HYPH cord-003926-ycdaw2vh 156 24 label label NN cord-003926-ycdaw2vh 156 25 , , , cord-003926-ycdaw2vh 156 26 phase phase NN cord-003926-ycdaw2vh 156 27 1 1 CD cord-003926-ycdaw2vh 156 28 clinical clinical JJ cord-003926-ycdaw2vh 156 29 trials trial NNS cord-003926-ycdaw2vh 156 30 Safety safety NN cord-003926-ycdaw2vh 156 31 and and CC cord-003926-ycdaw2vh 156 32 immunogenicity immunogenicity NN cord-003926-ycdaw2vh 156 33 of of IN cord-003926-ycdaw2vh 156 34 an an DT cord-003926-ycdaw2vh 156 35 anti anti JJ cord-003926-ycdaw2vh 156 36 - - JJ cord-003926-ycdaw2vh 156 37 Zika zika JJ cord-003926-ycdaw2vh 156 38 virus virus NN cord-003926-ycdaw2vh 156 39 DNA dna NN cord-003926-ycdaw2vh 156 40 vaccine vaccine NN cord-003926-ycdaw2vh 156 41 - - : cord-003926-ycdaw2vh 156 42 Preliminary Preliminary NNP cord-003926-ycdaw2vh 156 43 Report Report NNP cord-003926-ycdaw2vh 157 1 In in IN cord-003926-ycdaw2vh 157 2 vivo vivo NN cord-003926-ycdaw2vh 157 3 protection protection NN cord-003926-ycdaw2vh 157 4 against against IN cord-003926-ycdaw2vh 157 5 ZIKV ZIKV NNP cord-003926-ycdaw2vh 157 6 infection infection NN cord-003926-ycdaw2vh 157 7 and and CC cord-003926-ycdaw2vh 157 8 pathogenesis pathogenesis NN cord-003926-ycdaw2vh 157 9 through through IN cord-003926-ycdaw2vh 157 10 passive passive JJ cord-003926-ycdaw2vh 157 11 antibody antibody NN cord-003926-ycdaw2vh 157 12 transfer transfer NN cord-003926-ycdaw2vh 157 13 and and CC cord-003926-ycdaw2vh 157 14 active active JJ cord-003926-ycdaw2vh 157 15 immunization immunization NN cord-003926-ycdaw2vh 157 16 with with IN cord-003926-ycdaw2vh 157 17 a a DT cord-003926-ycdaw2vh 157 18 prMEnv prmenv JJ cord-003926-ycdaw2vh 157 19 DNA dna NN cord-003926-ycdaw2vh 157 20 vaccine vaccine NN cord-003926-ycdaw2vh 157 21 Rapid Rapid NNP cord-003926-ycdaw2vh 157 22 development development NN cord-003926-ycdaw2vh 157 23 of of IN cord-003926-ycdaw2vh 157 24 a a DT cord-003926-ycdaw2vh 157 25 DNA dna NN cord-003926-ycdaw2vh 157 26 vaccine vaccine NN cord-003926-ycdaw2vh 157 27 for for IN cord-003926-ycdaw2vh 157 28 Zika Zika NNP cord-003926-ycdaw2vh 157 29 virus virus NN cord-003926-ycdaw2vh 157 30 Preliminary preliminary JJ cord-003926-ycdaw2vh 157 31 aggregate aggregate JJ cord-003926-ycdaw2vh 157 32 safety safety NN cord-003926-ycdaw2vh 157 33 and and CC cord-003926-ycdaw2vh 157 34 immunogenicity immunogenicity NN cord-003926-ycdaw2vh 157 35 results result NNS cord-003926-ycdaw2vh 157 36 from from IN cord-003926-ycdaw2vh 157 37 three three CD cord-003926-ycdaw2vh 157 38 trials trial NNS cord-003926-ycdaw2vh 157 39 of of IN cord-003926-ycdaw2vh 157 40 a a DT cord-003926-ycdaw2vh 157 41 purified purify VBN cord-003926-ycdaw2vh 157 42 inactivated inactivate VBN cord-003926-ycdaw2vh 157 43 Zika Zika NNP cord-003926-ycdaw2vh 157 44 virus virus NN cord-003926-ycdaw2vh 157 45 vaccine vaccine NN cord-003926-ycdaw2vh 157 46 candidate candidate NN cord-003926-ycdaw2vh 157 47 : : : cord-003926-ycdaw2vh 157 48 Phase phase NN cord-003926-ycdaw2vh 157 49 1 1 CD cord-003926-ycdaw2vh 157 50 , , , cord-003926-ycdaw2vh 157 51 randomised randomised JJ cord-003926-ycdaw2vh 157 52 , , , cord-003926-ycdaw2vh 157 53 double double JJ cord-003926-ycdaw2vh 157 54 - - HYPH cord-003926-ycdaw2vh 157 55 blind blind JJ cord-003926-ycdaw2vh 157 56 , , , cord-003926-ycdaw2vh 157 57 placebo placebo NN cord-003926-ycdaw2vh 157 58 - - HYPH cord-003926-ycdaw2vh 157 59 controlled control VBN cord-003926-ycdaw2vh 157 60 clinical clinical JJ cord-003926-ycdaw2vh 157 61 trials trial NNS cord-003926-ycdaw2vh 157 62 Vaccine Vaccine NNP cord-003926-ycdaw2vh 157 63 protection protection NN cord-003926-ycdaw2vh 157 64 against against IN cord-003926-ycdaw2vh 157 65 Zika Zika NNP cord-003926-ycdaw2vh 157 66 virus virus NN cord-003926-ycdaw2vh 157 67 from from IN cord-003926-ycdaw2vh 157 68 Brazil Brazil NNP cord-003926-ycdaw2vh 157 69 Protective protective JJ cord-003926-ycdaw2vh 157 70 efficacy efficacy NN cord-003926-ycdaw2vh 157 71 of of IN cord-003926-ycdaw2vh 157 72 multiple multiple JJ cord-003926-ycdaw2vh 157 73 vaccine vaccine NN cord-003926-ycdaw2vh 157 74 platforms platform NNS cord-003926-ycdaw2vh 157 75 against against IN cord-003926-ycdaw2vh 157 76 Zika Zika NNP cord-003926-ycdaw2vh 157 77 virus virus NN cord-003926-ycdaw2vh 157 78 challenge challenge NN cord-003926-ycdaw2vh 157 79 in in IN cord-003926-ycdaw2vh 157 80 rhesus rhesu NNS cord-003926-ycdaw2vh 157 81 monkeys monkey NNS cord-003926-ycdaw2vh 158 1 Modified modify VBN cord-003926-ycdaw2vh 158 2 mRNA mrna NN cord-003926-ycdaw2vh 159 1 vaccines vaccine NNS cord-003926-ycdaw2vh 159 2 protect protect VBP cord-003926-ycdaw2vh 159 3 against against IN cord-003926-ycdaw2vh 159 4 Zika Zika NNP cord-003926-ycdaw2vh 159 5 virus virus NN cord-003926-ycdaw2vh 159 6 infection infection NN cord-003926-ycdaw2vh 159 7 Purified purify VBN cord-003926-ycdaw2vh 160 1 inactivated inactivate VBN cord-003926-ycdaw2vh 160 2 Zika Zika NNP cord-003926-ycdaw2vh 160 3 vaccine vaccine NN cord-003926-ycdaw2vh 160 4 candidates candidate NNS cord-003926-ycdaw2vh 160 5 afford afford VBP cord-003926-ycdaw2vh 160 6 protection protection NN cord-003926-ycdaw2vh 160 7 against against IN cord-003926-ycdaw2vh 160 8 lethal lethal JJ cord-003926-ycdaw2vh 160 9 challenge challenge NN cord-003926-ycdaw2vh 160 10 in in IN cord-003926-ycdaw2vh 160 11 mice mouse NNS cord-003926-ycdaw2vh 161 1 A a DT cord-003926-ycdaw2vh 161 2 measles measles NN cord-003926-ycdaw2vh 161 3 virus virus NN cord-003926-ycdaw2vh 161 4 - - HYPH cord-003926-ycdaw2vh 161 5 based base VBN cord-003926-ycdaw2vh 161 6 vaccine vaccine NN cord-003926-ycdaw2vh 161 7 candidate candidate NN cord-003926-ycdaw2vh 161 8 mediates mediate VBZ cord-003926-ycdaw2vh 161 9 protection protection NN cord-003926-ycdaw2vh 161 10 against against IN cord-003926-ycdaw2vh 161 11 Zika Zika NNP cord-003926-ycdaw2vh 161 12 virus virus NN cord-003926-ycdaw2vh 161 13 in in IN cord-003926-ycdaw2vh 161 14 an an DT cord-003926-ycdaw2vh 161 15 allogeneic allogeneic NN cord-003926-ycdaw2vh 161 16 mouse mouse NN cord-003926-ycdaw2vh 161 17 pregnancy pregnancy NN cord-003926-ycdaw2vh 161 18 model model NN cord-003926-ycdaw2vh 161 19 Animal Animal NNP cord-003926-ycdaw2vh 161 20 models model NNS cord-003926-ycdaw2vh 161 21 of of IN cord-003926-ycdaw2vh 161 22 Zika Zika NNP cord-003926-ycdaw2vh 161 23 virus virus NN cord-003926-ycdaw2vh 161 24 infection infection NN cord-003926-ycdaw2vh 161 25 , , , cord-003926-ycdaw2vh 162 1 pathogenesis pathogenesis NN cord-003926-ycdaw2vh 162 2 , , , cord-003926-ycdaw2vh 162 3 and and CC cord-003926-ycdaw2vh 162 4 immunity immunity NN cord-003926-ycdaw2vh 162 5 Zika Zika NNP cord-003926-ycdaw2vh 162 6 virus virus NN cord-003926-ycdaw2vh 162 7 infection infection NN cord-003926-ycdaw2vh 162 8 during during IN cord-003926-ycdaw2vh 162 9 pregnancy pregnancy NN cord-003926-ycdaw2vh 162 10 in in IN cord-003926-ycdaw2vh 162 11 mice mouse NNS cord-003926-ycdaw2vh 162 12 causes cause VBZ cord-003926-ycdaw2vh 162 13 placental placental JJ cord-003926-ycdaw2vh 162 14 damage damage NN cord-003926-ycdaw2vh 162 15 and and CC cord-003926-ycdaw2vh 162 16 fetal fetal JJ cord-003926-ycdaw2vh 162 17 demise demise NN cord-003926-ycdaw2vh 163 1 Increased increase VBN cord-003926-ycdaw2vh 163 2 hospitalizations hospitalization NNS cord-003926-ycdaw2vh 163 3 for for IN cord-003926-ycdaw2vh 163 4 neuropathies neuropathy NNS cord-003926-ycdaw2vh 163 5 as as IN cord-003926-ycdaw2vh 163 6 indicators indicator NNS cord-003926-ycdaw2vh 163 7 of of IN cord-003926-ycdaw2vh 163 8 Zika Zika NNP cord-003926-ycdaw2vh 163 9 virus virus NN cord-003926-ycdaw2vh 163 10 infection infection NN cord-003926-ycdaw2vh 163 11 , , , cord-003926-ycdaw2vh 163 12 according accord VBG cord-003926-ycdaw2vh 163 13 to to IN cord-003926-ycdaw2vh 163 14 Health Health NNP cord-003926-ycdaw2vh 163 15 Information Information NNP cord-003926-ycdaw2vh 163 16 System System NNP cord-003926-ycdaw2vh 163 17 data data VBZ cord-003926-ycdaw2vh 163 18 Guillain Guillain NNP cord-003926-ycdaw2vh 163 19 - - HYPH cord-003926-ycdaw2vh 163 20 Barré Barré NNP cord-003926-ycdaw2vh 163 21 syndrome syndrome NN cord-003926-ycdaw2vh 163 22 , , , cord-003926-ycdaw2vh 163 23 acute acute JJ cord-003926-ycdaw2vh 163 24 disseminated disseminate VBN cord-003926-ycdaw2vh 163 25 encephalomyelitis encephalomyelitis NN cord-003926-ycdaw2vh 163 26 and and CC cord-003926-ycdaw2vh 163 27 encephalitis encephalitis NN cord-003926-ycdaw2vh 163 28 associated associate VBN cord-003926-ycdaw2vh 163 29 with with IN cord-003926-ycdaw2vh 163 30 Zika Zika NNP cord-003926-ycdaw2vh 163 31 virus virus NN cord-003926-ycdaw2vh 163 32 infection infection NN cord-003926-ycdaw2vh 163 33 in in IN cord-003926-ycdaw2vh 163 34 Brazil Brazil NNP cord-003926-ycdaw2vh 163 35 : : : cord-003926-ycdaw2vh 163 36 Detection detection NN cord-003926-ycdaw2vh 163 37 of of IN cord-003926-ycdaw2vh 163 38 viral viral JJ cord-003926-ycdaw2vh 163 39 RNA RNA NNP cord-003926-ycdaw2vh 163 40 and and CC cord-003926-ycdaw2vh 163 41 Isolation Isolation NNP cord-003926-ycdaw2vh 163 42 of of IN cord-003926-ycdaw2vh 163 43 virus virus NN cord-003926-ycdaw2vh 163 44 during during IN cord-003926-ycdaw2vh 163 45 late late JJ cord-003926-ycdaw2vh 163 46 infection infection NN cord-003926-ycdaw2vh 163 47 Ethical ethical JJ cord-003926-ycdaw2vh 163 48 Considerations consideration NNS cord-003926-ycdaw2vh 163 49 for for IN cord-003926-ycdaw2vh 163 50 Zika Zika NNP cord-003926-ycdaw2vh 163 51 Virus Virus NNP cord-003926-ycdaw2vh 163 52 Human Human NNP cord-003926-ycdaw2vh 163 53 Challenge Challenge NNP cord-003926-ycdaw2vh 163 54 Trials Trials NNPS cord-003926-ycdaw2vh 163 55 ; ; : cord-003926-ycdaw2vh 163 56 National National NNP cord-003926-ycdaw2vh 163 57 Institutes Institutes NNPS cord-003926-ycdaw2vh 163 58 of of IN cord-003926-ycdaw2vh 163 59 Health Health NNP cord-003926-ycdaw2vh 163 60 Bystander Bystander NNP cord-003926-ycdaw2vh 163 61 risk risk NN cord-003926-ycdaw2vh 163 62 , , , cord-003926-ycdaw2vh 163 63 social social JJ cord-003926-ycdaw2vh 163 64 value value NN cord-003926-ycdaw2vh 163 65 , , , cord-003926-ycdaw2vh 163 66 and and CC cord-003926-ycdaw2vh 163 67 ethics ethic NNS cord-003926-ycdaw2vh 163 68 of of IN cord-003926-ycdaw2vh 163 69 human human JJ cord-003926-ycdaw2vh 163 70 research research NN cord-003926-ycdaw2vh 163 71 Zika Zika NNP cord-003926-ycdaw2vh 163 72 vaccines vaccine NNS cord-003926-ycdaw2vh 163 73 : : : cord-003926-ycdaw2vh 163 74 Role role NN cord-003926-ycdaw2vh 163 75 for for IN cord-003926-ycdaw2vh 163 76 controlled control VBN cord-003926-ycdaw2vh 163 77 human human JJ cord-003926-ycdaw2vh 163 78 infection infection NN