id sid tid token lemma pos cord-001397-nrq4ncdf 1 1 key key JJ cord-001397-nrq4ncdf 1 2 : : : cord-001397-nrq4ncdf 1 3 cord-001397-nrq4ncdf cord-001397-nrq4ncdf NNS cord-001397-nrq4ncdf 1 4 authors author NNS cord-001397-nrq4ncdf 1 5 : : : cord-001397-nrq4ncdf 1 6 Mlera Mlera NNP cord-001397-nrq4ncdf 1 7 , , , cord-001397-nrq4ncdf 1 8 Luwanika Luwanika NNP cord-001397-nrq4ncdf 1 9 ; ; : cord-001397-nrq4ncdf 1 10 Melik Melik NNP cord-001397-nrq4ncdf 1 11 , , , cord-001397-nrq4ncdf 1 12 Wessam Wessam NNP cord-001397-nrq4ncdf 1 13 ; ; : cord-001397-nrq4ncdf 1 14 Bloom Bloom NNP cord-001397-nrq4ncdf 1 15 , , , cord-001397-nrq4ncdf 1 16 Marshall Marshall NNP cord-001397-nrq4ncdf 1 17 E. E. NNP cord-001397-nrq4ncdf 1 18 title title NN cord-001397-nrq4ncdf 1 19 : : : cord-001397-nrq4ncdf 1 20 The the DT cord-001397-nrq4ncdf 1 21 role role NN cord-001397-nrq4ncdf 1 22 of of IN cord-001397-nrq4ncdf 1 23 viral viral JJ cord-001397-nrq4ncdf 1 24 persistence persistence NN cord-001397-nrq4ncdf 1 25 in in IN cord-001397-nrq4ncdf 1 26 flavivirus flavivirus JJ cord-001397-nrq4ncdf 1 27 biology biology NN cord-001397-nrq4ncdf 1 28 date date NN cord-001397-nrq4ncdf 1 29 : : : cord-001397-nrq4ncdf 1 30 2014 2014 CD cord-001397-nrq4ncdf 1 31 - - HYPH cord-001397-nrq4ncdf 1 32 05 05 CD cord-001397-nrq4ncdf 1 33 - - HYPH cord-001397-nrq4ncdf 1 34 12 12 CD cord-001397-nrq4ncdf 1 35 journal journal NN cord-001397-nrq4ncdf 1 36 : : : cord-001397-nrq4ncdf 1 37 Pathogens Pathogens NNPS cord-001397-nrq4ncdf 1 38 and and CC cord-001397-nrq4ncdf 1 39 Disease Disease NNP cord-001397-nrq4ncdf 1 40 DOI DOI NNP cord-001397-nrq4ncdf 1 41 : : : cord-001397-nrq4ncdf 1 42 10.1111/2049 10.1111/2049 CD cord-001397-nrq4ncdf 1 43 - - HYPH cord-001397-nrq4ncdf 1 44 632x.12178 632x.12178 NN cord-001397-nrq4ncdf 2 1 sha sha NNP cord-001397-nrq4ncdf 2 2 : : : cord-001397-nrq4ncdf 3 1 233699c0de054188ceb502caa5f08640bf75c619 233699c0de054188ceb502caa5f08640bf75c619 CD cord-001397-nrq4ncdf 4 1 doc_id doc_id LS cord-001397-nrq4ncdf 4 2 : : : cord-001397-nrq4ncdf 4 3 1397 1397 CD cord-001397-nrq4ncdf 4 4 cord_uid cord_uid FW cord-001397-nrq4ncdf 4 5 : : : cord-001397-nrq4ncdf 5 1 nrq4ncdf nrq4ncdf NNP cord-001397-nrq4ncdf 6 1 In in IN cord-001397-nrq4ncdf 6 2 nature nature NN cord-001397-nrq4ncdf 6 3 , , , cord-001397-nrq4ncdf 6 4 vector vector NN cord-001397-nrq4ncdf 6 5 - - HYPH cord-001397-nrq4ncdf 6 6 borne bear VBN cord-001397-nrq4ncdf 6 7 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 6 8 are be VBP cord-001397-nrq4ncdf 6 9 persistently persistently RB cord-001397-nrq4ncdf 6 10 cycled cycle VBN cord-001397-nrq4ncdf 6 11 between between IN cord-001397-nrq4ncdf 6 12 either either CC cord-001397-nrq4ncdf 6 13 the the DT cord-001397-nrq4ncdf 6 14 tick tick NN cord-001397-nrq4ncdf 6 15 or or CC cord-001397-nrq4ncdf 6 16 mosquito mosquito NN cord-001397-nrq4ncdf 6 17 vector vector NN cord-001397-nrq4ncdf 6 18 and and CC cord-001397-nrq4ncdf 6 19 small small JJ cord-001397-nrq4ncdf 6 20 mammals mammal NNS cord-001397-nrq4ncdf 6 21 such such JJ cord-001397-nrq4ncdf 6 22 as as IN cord-001397-nrq4ncdf 6 23 rodents rodent NNS cord-001397-nrq4ncdf 6 24 , , , cord-001397-nrq4ncdf 6 25 skunks skunk NNS cord-001397-nrq4ncdf 6 26 , , , cord-001397-nrq4ncdf 6 27 and and CC cord-001397-nrq4ncdf 6 28 swine swine NN cord-001397-nrq4ncdf 6 29 . . . cord-001397-nrq4ncdf 7 1 These these DT cord-001397-nrq4ncdf 7 2 viruses virus NNS cord-001397-nrq4ncdf 7 3 account account VBP cord-001397-nrq4ncdf 7 4 for for IN cord-001397-nrq4ncdf 7 5 considerable considerable JJ cord-001397-nrq4ncdf 7 6 human human JJ cord-001397-nrq4ncdf 7 7 morbidity morbidity NN cord-001397-nrq4ncdf 7 8 and and CC cord-001397-nrq4ncdf 7 9 mortality mortality NN cord-001397-nrq4ncdf 7 10 worldwide worldwide RB cord-001397-nrq4ncdf 7 11 . . . cord-001397-nrq4ncdf 8 1 Increasing increase VBG cord-001397-nrq4ncdf 8 2 and and CC cord-001397-nrq4ncdf 8 3 substantial substantial JJ cord-001397-nrq4ncdf 8 4 evidence evidence NN cord-001397-nrq4ncdf 8 5 of of IN cord-001397-nrq4ncdf 8 6 viral viral JJ cord-001397-nrq4ncdf 8 7 persistence persistence NN cord-001397-nrq4ncdf 8 8 in in IN cord-001397-nrq4ncdf 8 9 humans human NNS cord-001397-nrq4ncdf 8 10 , , , cord-001397-nrq4ncdf 8 11 which which WDT cord-001397-nrq4ncdf 8 12 includes include VBZ cord-001397-nrq4ncdf 8 13 the the DT cord-001397-nrq4ncdf 8 14 isolation isolation NN cord-001397-nrq4ncdf 8 15 of of IN cord-001397-nrq4ncdf 8 16 RNA RNA NNP cord-001397-nrq4ncdf 8 17 by by IN cord-001397-nrq4ncdf 8 18 RT RT NNP cord-001397-nrq4ncdf 8 19 - - HYPH cord-001397-nrq4ncdf 8 20 PCR PCR NNP cord-001397-nrq4ncdf 8 21 and and CC cord-001397-nrq4ncdf 8 22 infectious infectious JJ cord-001397-nrq4ncdf 8 23 virus virus NN cord-001397-nrq4ncdf 8 24 by by IN cord-001397-nrq4ncdf 8 25 culture culture NN cord-001397-nrq4ncdf 8 26 , , , cord-001397-nrq4ncdf 8 27 continues continue VBZ cord-001397-nrq4ncdf 8 28 to to TO cord-001397-nrq4ncdf 8 29 be be VB cord-001397-nrq4ncdf 8 30 reported report VBN cord-001397-nrq4ncdf 8 31 . . . cord-001397-nrq4ncdf 9 1 Viral viral JJ cord-001397-nrq4ncdf 9 2 persistence persistence NN cord-001397-nrq4ncdf 9 3 can can MD cord-001397-nrq4ncdf 9 4 also also RB cord-001397-nrq4ncdf 9 5 be be VB cord-001397-nrq4ncdf 9 6 established establish VBN cord-001397-nrq4ncdf 9 7 in in IN cord-001397-nrq4ncdf 9 8 vitro vitro FW cord-001397-nrq4ncdf 9 9 in in IN cord-001397-nrq4ncdf 9 10 various various JJ cord-001397-nrq4ncdf 9 11 human human NN cord-001397-nrq4ncdf 9 12 , , , cord-001397-nrq4ncdf 9 13 animal animal NN cord-001397-nrq4ncdf 9 14 , , , cord-001397-nrq4ncdf 9 15 arachnid arachnid NN cord-001397-nrq4ncdf 9 16 and and CC cord-001397-nrq4ncdf 9 17 insect insect NN cord-001397-nrq4ncdf 9 18 cell cell NN cord-001397-nrq4ncdf 9 19 lines line NNS cord-001397-nrq4ncdf 9 20 in in IN cord-001397-nrq4ncdf 9 21 culture culture NN cord-001397-nrq4ncdf 9 22 . . . cord-001397-nrq4ncdf 10 1 Although although IN cord-001397-nrq4ncdf 10 2 some some DT cord-001397-nrq4ncdf 10 3 research research NN cord-001397-nrq4ncdf 10 4 has have VBZ cord-001397-nrq4ncdf 10 5 focused focus VBN cord-001397-nrq4ncdf 10 6 on on IN cord-001397-nrq4ncdf 10 7 the the DT cord-001397-nrq4ncdf 10 8 potential potential JJ cord-001397-nrq4ncdf 10 9 roles role NNS cord-001397-nrq4ncdf 10 10 of of IN cord-001397-nrq4ncdf 10 11 defective defective JJ cord-001397-nrq4ncdf 10 12 virus virus NN cord-001397-nrq4ncdf 10 13 particles particle NNS cord-001397-nrq4ncdf 10 14 , , , cord-001397-nrq4ncdf 10 15 evasion evasion NN cord-001397-nrq4ncdf 10 16 of of IN cord-001397-nrq4ncdf 10 17 the the DT cord-001397-nrq4ncdf 10 18 immune immune JJ cord-001397-nrq4ncdf 10 19 response response NN cord-001397-nrq4ncdf 10 20 through through IN cord-001397-nrq4ncdf 10 21 the the DT cord-001397-nrq4ncdf 10 22 manipulation manipulation NN cord-001397-nrq4ncdf 10 23 of of IN cord-001397-nrq4ncdf 10 24 autophagy autophagy NN cord-001397-nrq4ncdf 10 25 and/or and/or CC cord-001397-nrq4ncdf 10 26 apoptosis apoptosis NN cord-001397-nrq4ncdf 10 27 , , , cord-001397-nrq4ncdf 10 28 the the DT cord-001397-nrq4ncdf 10 29 precise precise JJ cord-001397-nrq4ncdf 10 30 mechanism mechanism NN cord-001397-nrq4ncdf 10 31 of of IN cord-001397-nrq4ncdf 10 32 flavivirus flavivirus JJ cord-001397-nrq4ncdf 10 33 persistence persistence NN cord-001397-nrq4ncdf 10 34 is be VBZ cord-001397-nrq4ncdf 10 35 still still RB cord-001397-nrq4ncdf 10 36 not not RB cord-001397-nrq4ncdf 10 37 well well RB cord-001397-nrq4ncdf 10 38 understood understand VBN cord-001397-nrq4ncdf 10 39 . . . cord-001397-nrq4ncdf 11 1 We -PRON- PRP cord-001397-nrq4ncdf 11 2 propose propose VBP cord-001397-nrq4ncdf 11 3 additional additional JJ cord-001397-nrq4ncdf 11 4 research research NN cord-001397-nrq4ncdf 11 5 for for IN cord-001397-nrq4ncdf 11 6 further further JJ cord-001397-nrq4ncdf 11 7 understanding understanding NN cord-001397-nrq4ncdf 11 8 of of IN cord-001397-nrq4ncdf 11 9 how how WRB cord-001397-nrq4ncdf 11 10 viral viral JJ cord-001397-nrq4ncdf 11 11 persistence persistence NN cord-001397-nrq4ncdf 11 12 is be VBZ cord-001397-nrq4ncdf 11 13 established establish VBN cord-001397-nrq4ncdf 11 14 in in IN cord-001397-nrq4ncdf 11 15 different different JJ cord-001397-nrq4ncdf 11 16 systems system NNS cord-001397-nrq4ncdf 11 17 . . . cord-001397-nrq4ncdf 12 1 Avenues avenue NNS cord-001397-nrq4ncdf 12 2 for for IN cord-001397-nrq4ncdf 12 3 additional additional JJ cord-001397-nrq4ncdf 12 4 studies study NNS cord-001397-nrq4ncdf 12 5 include include VBP cord-001397-nrq4ncdf 12 6 determining determine VBG cord-001397-nrq4ncdf 12 7 if if IN cord-001397-nrq4ncdf 12 8 the the DT cord-001397-nrq4ncdf 12 9 multifunctional multifunctional JJ cord-001397-nrq4ncdf 12 10 flavivirus flavivirus NNP cord-001397-nrq4ncdf 12 11 protein protein NN cord-001397-nrq4ncdf 12 12 NS5 NS5 NNP cord-001397-nrq4ncdf 12 13 has have VBZ cord-001397-nrq4ncdf 12 14 a a DT cord-001397-nrq4ncdf 12 15 role role NN cord-001397-nrq4ncdf 12 16 in in IN cord-001397-nrq4ncdf 12 17 viral viral JJ cord-001397-nrq4ncdf 12 18 persistence persistence NN cord-001397-nrq4ncdf 12 19 , , , cord-001397-nrq4ncdf 12 20 the the DT cord-001397-nrq4ncdf 12 21 development development NN cord-001397-nrq4ncdf 12 22 of of IN cord-001397-nrq4ncdf 12 23 relevant relevant JJ cord-001397-nrq4ncdf 12 24 animal animal NN cord-001397-nrq4ncdf 12 25 models model NNS cord-001397-nrq4ncdf 12 26 of of IN cord-001397-nrq4ncdf 12 27 viral viral JJ cord-001397-nrq4ncdf 12 28 persistence persistence NN cord-001397-nrq4ncdf 12 29 as as RB cord-001397-nrq4ncdf 12 30 well well RB cord-001397-nrq4ncdf 12 31 as as IN cord-001397-nrq4ncdf 12 32 investigating investigate VBG cord-001397-nrq4ncdf 12 33 the the DT cord-001397-nrq4ncdf 12 34 host host NN cord-001397-nrq4ncdf 12 35 responses response NNS cord-001397-nrq4ncdf 12 36 that that WDT cord-001397-nrq4ncdf 12 37 allow allow VBP cord-001397-nrq4ncdf 12 38 vector vector NN cord-001397-nrq4ncdf 12 39 borne bear VBN cord-001397-nrq4ncdf 12 40 flavivirus flavivirus JJ cord-001397-nrq4ncdf 12 41 replication replication NN cord-001397-nrq4ncdf 12 42 without without IN cord-001397-nrq4ncdf 12 43 detrimental detrimental JJ cord-001397-nrq4ncdf 12 44 effects effect NNS cord-001397-nrq4ncdf 12 45 on on IN cord-001397-nrq4ncdf 12 46 infected infected JJ cord-001397-nrq4ncdf 12 47 cells cell NNS cord-001397-nrq4ncdf 12 48 . . . cord-001397-nrq4ncdf 13 1 Such such JJ cord-001397-nrq4ncdf 13 2 studies study NNS cord-001397-nrq4ncdf 13 3 might may MD cord-001397-nrq4ncdf 13 4 shed shed VB cord-001397-nrq4ncdf 13 5 more more JJR cord-001397-nrq4ncdf 13 6 light light NN cord-001397-nrq4ncdf 13 7 on on IN cord-001397-nrq4ncdf 13 8 the the DT cord-001397-nrq4ncdf 13 9 viral viral JJ cord-001397-nrq4ncdf 13 10 - - HYPH cord-001397-nrq4ncdf 13 11 host host NN cord-001397-nrq4ncdf 13 12 relationships relationship NNS cord-001397-nrq4ncdf 13 13 , , , cord-001397-nrq4ncdf 13 14 and and CC cord-001397-nrq4ncdf 13 15 could could MD cord-001397-nrq4ncdf 13 16 be be VB cord-001397-nrq4ncdf 13 17 used use VBN cord-001397-nrq4ncdf 13 18 to to TO cord-001397-nrq4ncdf 13 19 unravel unravel VB cord-001397-nrq4ncdf 13 20 the the DT cord-001397-nrq4ncdf 13 21 mechanisms mechanism NNS cord-001397-nrq4ncdf 13 22 for for IN cord-001397-nrq4ncdf 13 23 establishment establishment NN cord-001397-nrq4ncdf 13 24 of of IN cord-001397-nrq4ncdf 13 25 persistence persistence NN cord-001397-nrq4ncdf 13 26 . . . cord-001397-nrq4ncdf 14 1 Defining define VBG cord-001397-nrq4ncdf 14 2 mechanisms mechanism NNS cord-001397-nrq4ncdf 14 3 of of IN cord-001397-nrq4ncdf 14 4 viral viral JJ cord-001397-nrq4ncdf 14 5 persistence persistence NN cord-001397-nrq4ncdf 14 6 will will MD cord-001397-nrq4ncdf 14 7 be be VB cord-001397-nrq4ncdf 14 8 critical critical JJ cord-001397-nrq4ncdf 14 9 for for IN cord-001397-nrq4ncdf 14 10 understanding understand VBG cord-001397-nrq4ncdf 14 11 vector vector NN cord-001397-nrq4ncdf 14 12 - - : cord-001397-nrq4ncdf 14 13 borne bear VBN cord-001397-nrq4ncdf 14 14 flavivirus flavivirus JJ cord-001397-nrq4ncdf 14 15 infections infection NNS cord-001397-nrq4ncdf 14 16 . . . cord-001397-nrq4ncdf 15 1 These these DT cord-001397-nrq4ncdf 15 2 viral viral JJ cord-001397-nrq4ncdf 15 3 infections infection NNS cord-001397-nrq4ncdf 15 4 account account VBP cord-001397-nrq4ncdf 15 5 for for IN cord-001397-nrq4ncdf 15 6 considerable considerable JJ cord-001397-nrq4ncdf 15 7 human human JJ cord-001397-nrq4ncdf 15 8 morbidity morbidity NN cord-001397-nrq4ncdf 15 9 and and CC cord-001397-nrq4ncdf 15 10 mortality mortality NN cord-001397-nrq4ncdf 15 11 worldwide worldwide RB cord-001397-nrq4ncdf 15 12 . . . cord-001397-nrq4ncdf 16 1 Furthermore furthermore RB cord-001397-nrq4ncdf 16 2 , , , cord-001397-nrq4ncdf 16 3 incidence incidence NN cord-001397-nrq4ncdf 16 4 is be VBZ cord-001397-nrq4ncdf 16 5 increasing increase VBG cord-001397-nrq4ncdf 16 6 and and CC cord-001397-nrq4ncdf 16 7 infections infection NNS cord-001397-nrq4ncdf 16 8 are be VBP cord-001397-nrq4ncdf 16 9 being be VBG cord-001397-nrq4ncdf 16 10 appreciated appreciate VBN cord-001397-nrq4ncdf 16 11 in in IN cord-001397-nrq4ncdf 16 12 previously previously RB cord-001397-nrq4ncdf 16 13 nonendemic nonendemic NNP cord-001397-nrq4ncdf 16 14 geographic geographic JJ cord-001397-nrq4ncdf 16 15 locations location NNS cord-001397-nrq4ncdf 16 16 . . . cord-001397-nrq4ncdf 17 1 Prominent prominent JJ cord-001397-nrq4ncdf 17 2 vector vector NN cord-001397-nrq4ncdf 17 3 - - HYPH cord-001397-nrq4ncdf 17 4 borne bear VBN cord-001397-nrq4ncdf 17 5 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 17 6 ( ( -LRB- cord-001397-nrq4ncdf 17 7 VBFVs vbfv NNS cord-001397-nrq4ncdf 17 8 ) ) -RRB- cord-001397-nrq4ncdf 17 9 associated associate VBN cord-001397-nrq4ncdf 17 10 with with IN cord-001397-nrq4ncdf 17 11 significant significant JJ cord-001397-nrq4ncdf 17 12 human human JJ cord-001397-nrq4ncdf 17 13 infections infection NNS cord-001397-nrq4ncdf 17 14 include include VBP cord-001397-nrq4ncdf 17 15 both both DT cord-001397-nrq4ncdf 17 16 tick tick VB cord-001397-nrq4ncdf 17 17 - - HYPH cord-001397-nrq4ncdf 17 18 borne bear VBN cord-001397-nrq4ncdf 17 19 and and CC cord-001397-nrq4ncdf 17 20 mosquito mosquito NN cord-001397-nrq4ncdf 17 21 - - HYPH cord-001397-nrq4ncdf 17 22 borne bear VBN cord-001397-nrq4ncdf 17 23 agents agent NNS cord-001397-nrq4ncdf 17 24 . . . cord-001397-nrq4ncdf 18 1 The the DT cord-001397-nrq4ncdf 18 2 tick tick NN cord-001397-nrq4ncdf 18 3 - - HYPH cord-001397-nrq4ncdf 18 4 borne bear VBN cord-001397-nrq4ncdf 18 5 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 18 6 ( ( -LRB- cord-001397-nrq4ncdf 18 7 TBFVs tbfv NNS cord-001397-nrq4ncdf 18 8 ) ) -RRB- cord-001397-nrq4ncdf 18 9 are be VBP cord-001397-nrq4ncdf 18 10 exemplified exemplify VBN cord-001397-nrq4ncdf 18 11 by by IN cord-001397-nrq4ncdf 18 12 the the DT cord-001397-nrq4ncdf 18 13 tick tick NN cord-001397-nrq4ncdf 18 14 - - HYPH cord-001397-nrq4ncdf 18 15 borne bear VBN cord-001397-nrq4ncdf 18 16 encephalitis encephalitis JJ cord-001397-nrq4ncdf 18 17 virus virus NN cord-001397-nrq4ncdf 18 18 ( ( -LRB- cord-001397-nrq4ncdf 18 19 TBEV TBEV NNP cord-001397-nrq4ncdf 18 20 ) ) -RRB- cord-001397-nrq4ncdf 18 21 sero sero NN cord-001397-nrq4ncdf 18 22 - - HYPH cord-001397-nrq4ncdf 18 23 complex complex JJ cord-001397-nrq4ncdf 18 24 group group NN cord-001397-nrq4ncdf 18 25 , , , cord-001397-nrq4ncdf 18 26 Omsk Omsk NNP cord-001397-nrq4ncdf 18 27 hemorrhagic hemorrhagic JJ cord-001397-nrq4ncdf 18 28 fever fever NN cord-001397-nrq4ncdf 18 29 virus virus NN cord-001397-nrq4ncdf 18 30 , , , cord-001397-nrq4ncdf 18 31 Kyasanur Kyasanur NNP cord-001397-nrq4ncdf 18 32 forest forest NN cord-001397-nrq4ncdf 18 33 disease disease NN cord-001397-nrq4ncdf 18 34 virus virus NN cord-001397-nrq4ncdf 18 35 , , , cord-001397-nrq4ncdf 18 36 Alkhurma Alkhurma NNP cord-001397-nrq4ncdf 18 37 virus virus NN cord-001397-nrq4ncdf 18 38 , , , cord-001397-nrq4ncdf 18 39 Powassan Powassan NNP cord-001397-nrq4ncdf 18 40 virus virus NN cord-001397-nrq4ncdf 18 41 ( ( -LRB- cord-001397-nrq4ncdf 18 42 POWV POWV NNP cord-001397-nrq4ncdf 18 43 ) ) -RRB- cord-001397-nrq4ncdf 18 44 , , , cord-001397-nrq4ncdf 18 45 and and CC cord-001397-nrq4ncdf 18 46 deer deer NN cord-001397-nrq4ncdf 18 47 tick tick NN cord-001397-nrq4ncdf 18 48 virus virus NN cord-001397-nrq4ncdf 18 49 ( ( -LRB- cord-001397-nrq4ncdf 18 50 DTV DTV NNP cord-001397-nrq4ncdf 18 51 ) ) -RRB- cord-001397-nrq4ncdf 18 52 , , . cord-001397-nrq4ncdf 19 1 the the DT cord-001397-nrq4ncdf 19 2 latter latter JJ cord-001397-nrq4ncdf 19 3 two two CD cord-001397-nrq4ncdf 19 4 occurring occur VBG cord-001397-nrq4ncdf 19 5 in in IN cord-001397-nrq4ncdf 19 6 the the DT cord-001397-nrq4ncdf 19 7 United United NNP cord-001397-nrq4ncdf 19 8 States States NNP cord-001397-nrq4ncdf 19 9 ( ( -LRB- cord-001397-nrq4ncdf 19 10 Holbrook Holbrook NNP cord-001397-nrq4ncdf 19 11 et et NNP cord-001397-nrq4ncdf 19 12 al al NNP cord-001397-nrq4ncdf 19 13 . . NNP cord-001397-nrq4ncdf 19 14 , , , cord-001397-nrq4ncdf 19 15 2005 2005 CD cord-001397-nrq4ncdf 19 16 ; ; : cord-001397-nrq4ncdf 20 1 Brackney Brackney NNP cord-001397-nrq4ncdf 20 2 et et NNP cord-001397-nrq4ncdf 20 3 al al NNP cord-001397-nrq4ncdf 20 4 . . NNP cord-001397-nrq4ncdf 20 5 , , , cord-001397-nrq4ncdf 20 6 2008b 2008b CD cord-001397-nrq4ncdf 21 1 ; ; : cord-001397-nrq4ncdf 21 2 Ebel Ebel NNP cord-001397-nrq4ncdf 21 3 , , , cord-001397-nrq4ncdf 21 4 2010 2010 CD cord-001397-nrq4ncdf 21 5 ) ) -RRB- cord-001397-nrq4ncdf 21 6 . . . cord-001397-nrq4ncdf 22 1 The the DT cord-001397-nrq4ncdf 22 2 mosquito mosquito NN cord-001397-nrq4ncdf 22 3 - - HYPH cord-001397-nrq4ncdf 22 4 borne bear VBN cord-001397-nrq4ncdf 22 5 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 22 6 ( ( -LRB- cord-001397-nrq4ncdf 22 7 MBFVs mbfv NNS cord-001397-nrq4ncdf 22 8 ) ) -RRB- cord-001397-nrq4ncdf 22 9 are be VBP cord-001397-nrq4ncdf 22 10 perhaps perhaps RB cord-001397-nrq4ncdf 22 11 better well RBR cord-001397-nrq4ncdf 22 12 known know VBN cord-001397-nrq4ncdf 22 13 and and CC cord-001397-nrq4ncdf 22 14 include include VBP cord-001397-nrq4ncdf 22 15 yellow yellow JJ cord-001397-nrq4ncdf 22 16 fever fever NN cord-001397-nrq4ncdf 22 17 virus virus NN cord-001397-nrq4ncdf 22 18 ( ( -LRB- cord-001397-nrq4ncdf 22 19 YFV YFV NNP cord-001397-nrq4ncdf 22 20 ) ) -RRB- cord-001397-nrq4ncdf 22 21 , , , cord-001397-nrq4ncdf 22 22 West West NNP cord-001397-nrq4ncdf 22 23 Nile Nile NNP cord-001397-nrq4ncdf 22 24 virus virus NN cord-001397-nrq4ncdf 22 25 ( ( -LRB- cord-001397-nrq4ncdf 22 26 WNV WNV NNP cord-001397-nrq4ncdf 22 27 ) ) -RRB- cord-001397-nrq4ncdf 22 28 , , , cord-001397-nrq4ncdf 22 29 Japanese japanese JJ cord-001397-nrq4ncdf 22 30 encephalitis encephalitis RB cord-001397-nrq4ncdf 22 31 virus virus NN cord-001397-nrq4ncdf 22 32 ( ( -LRB- cord-001397-nrq4ncdf 22 33 JEV JEV NNP cord-001397-nrq4ncdf 22 34 ) ) -RRB- cord-001397-nrq4ncdf 22 35 , , , cord-001397-nrq4ncdf 22 36 and and CC cord-001397-nrq4ncdf 22 37 dengue dengue NN cord-001397-nrq4ncdf 22 38 virus virus NN cord-001397-nrq4ncdf 22 39 ( ( -LRB- cord-001397-nrq4ncdf 22 40 DENV DENV NNP cord-001397-nrq4ncdf 22 41 ) ) -RRB- cord-001397-nrq4ncdf 22 42 serotypes serotypes . cord-001397-nrq4ncdf 23 1 1 1 LS cord-001397-nrq4ncdf 23 2 - - SYM cord-001397-nrq4ncdf 23 3 4 4 CD cord-001397-nrq4ncdf 23 4 . . . cord-001397-nrq4ncdf 24 1 Infections infection NNS cord-001397-nrq4ncdf 24 2 with with IN cord-001397-nrq4ncdf 24 3 all all DT cord-001397-nrq4ncdf 24 4 of of IN cord-001397-nrq4ncdf 24 5 these these DT cord-001397-nrq4ncdf 24 6 viruses virus NNS cord-001397-nrq4ncdf 24 7 can can MD cord-001397-nrq4ncdf 24 8 lead lead VB cord-001397-nrq4ncdf 24 9 to to IN cord-001397-nrq4ncdf 24 10 severe severe JJ cord-001397-nrq4ncdf 24 11 disease disease NN cord-001397-nrq4ncdf 24 12 , , , cord-001397-nrq4ncdf 24 13 prolonged prolong VBN cord-001397-nrq4ncdf 24 14 debilitating debilitating JJ cord-001397-nrq4ncdf 24 15 neurological neurological JJ cord-001397-nrq4ncdf 24 16 sequelae sequela NNS cord-001397-nrq4ncdf 24 17 , , , cord-001397-nrq4ncdf 24 18 hemorrhagic hemorrhagic JJ cord-001397-nrq4ncdf 24 19 fever fever NN cord-001397-nrq4ncdf 24 20 , , , cord-001397-nrq4ncdf 24 21 and/ and/ CD cord-001397-nrq4ncdf 24 22 or or CC cord-001397-nrq4ncdf 24 23 death death NN cord-001397-nrq4ncdf 24 24 in in IN cord-001397-nrq4ncdf 24 25 some some DT cord-001397-nrq4ncdf 24 26 cases case NNS cord-001397-nrq4ncdf 24 27 ( ( -LRB- cord-001397-nrq4ncdf 24 28 Solomon Solomon NNP cord-001397-nrq4ncdf 24 29 et et NNP cord-001397-nrq4ncdf 24 30 al al NNP cord-001397-nrq4ncdf 24 31 . . NNP cord-001397-nrq4ncdf 24 32 , , , cord-001397-nrq4ncdf 24 33 1998 1998 CD cord-001397-nrq4ncdf 24 34 ; ; : cord-001397-nrq4ncdf 24 35 Glass Glass NNP cord-001397-nrq4ncdf 24 36 et et NNP cord-001397-nrq4ncdf 24 37 al al NNP cord-001397-nrq4ncdf 24 38 . . NNP cord-001397-nrq4ncdf 24 39 , , , cord-001397-nrq4ncdf 24 40 2002 2002 CD cord-001397-nrq4ncdf 24 41 ; ; : cord-001397-nrq4ncdf 25 1 Haglund Haglund NNP cord-001397-nrq4ncdf 25 2 & & CC cord-001397-nrq4ncdf 25 3 Gunther Gunther NNP cord-001397-nrq4ncdf 25 4 , , , cord-001397-nrq4ncdf 25 5 2003 2003 CD cord-001397-nrq4ncdf 25 6 ; ; : cord-001397-nrq4ncdf 25 7 Madden Madden NNP cord-001397-nrq4ncdf 25 8 , , , cord-001397-nrq4ncdf 25 9 2003 2003 CD cord-001397-nrq4ncdf 25 10 ; ; : cord-001397-nrq4ncdf 25 11 Van Van NNP cord-001397-nrq4ncdf 25 12 Gerpen Gerpen NNP cord-001397-nrq4ncdf 25 13 , , , cord-001397-nrq4ncdf 25 14 2003 2003 CD cord-001397-nrq4ncdf 25 15 ; ; : cord-001397-nrq4ncdf 25 16 Carson Carson NNP cord-001397-nrq4ncdf 25 17 et et NNP cord-001397-nrq4ncdf 25 18 al al NNP cord-001397-nrq4ncdf 25 19 . . NNP cord-001397-nrq4ncdf 25 20 , , , cord-001397-nrq4ncdf 25 21 2006 2006 CD cord-001397-nrq4ncdf 25 22 ) ) -RRB- cord-001397-nrq4ncdf 25 23 . . . cord-001397-nrq4ncdf 26 1 Viral viral JJ cord-001397-nrq4ncdf 26 2 persistence persistence NN cord-001397-nrq4ncdf 26 3 is be VBZ cord-001397-nrq4ncdf 26 4 a a DT cord-001397-nrq4ncdf 26 5 hallmark hallmark NN cord-001397-nrq4ncdf 26 6 of of IN cord-001397-nrq4ncdf 26 7 the the DT cord-001397-nrq4ncdf 26 8 ecology ecology NN cord-001397-nrq4ncdf 26 9 of of IN cord-001397-nrq4ncdf 26 10 VBFVs vbfv NNS cord-001397-nrq4ncdf 26 11 . . . cord-001397-nrq4ncdf 27 1 Both both DT cord-001397-nrq4ncdf 27 2 TBFVs tbfv NNS cord-001397-nrq4ncdf 27 3 and and CC cord-001397-nrq4ncdf 27 4 MBFVs mbfv NNS cord-001397-nrq4ncdf 27 5 are be VBP cord-001397-nrq4ncdf 27 6 cycled cycle VBN cord-001397-nrq4ncdf 27 7 between between IN cord-001397-nrq4ncdf 27 8 arthropod arthropod NN cord-001397-nrq4ncdf 27 9 and and CC cord-001397-nrq4ncdf 27 10 vertebrate vertebrate JJ cord-001397-nrq4ncdf 27 11 hosts host NNS cord-001397-nrq4ncdf 27 12 ( ( -LRB- cord-001397-nrq4ncdf 27 13 Figs Figs NNP cord-001397-nrq4ncdf 27 14 1 1 CD cord-001397-nrq4ncdf 27 15 and and CC cord-001397-nrq4ncdf 27 16 2 2 CD cord-001397-nrq4ncdf 27 17 ) ) -RRB- cord-001397-nrq4ncdf 27 18 , , , cord-001397-nrq4ncdf 27 19 and and CC cord-001397-nrq4ncdf 27 20 in in IN cord-001397-nrq4ncdf 27 21 many many JJ cord-001397-nrq4ncdf 27 22 cases case NNS cord-001397-nrq4ncdf 27 23 , , , cord-001397-nrq4ncdf 27 24 they -PRON- PRP cord-001397-nrq4ncdf 27 25 are be VBP cord-001397-nrq4ncdf 27 26 maintained maintain VBN cord-001397-nrq4ncdf 27 27 without without IN cord-001397-nrq4ncdf 27 28 deleterious deleterious JJ cord-001397-nrq4ncdf 27 29 effects effect NNS cord-001397-nrq4ncdf 27 30 on on IN cord-001397-nrq4ncdf 27 31 the the DT cord-001397-nrq4ncdf 27 32 hosts host NNS cord-001397-nrq4ncdf 27 33 . . . cord-001397-nrq4ncdf 28 1 In in IN cord-001397-nrq4ncdf 28 2 nature nature NN cord-001397-nrq4ncdf 28 3 , , , cord-001397-nrq4ncdf 28 4 TBFVs tbfvs CC cord-001397-nrq4ncdf 28 5 , , , cord-001397-nrq4ncdf 28 6 such such JJ cord-001397-nrq4ncdf 28 7 as as IN cord-001397-nrq4ncdf 28 8 POWV POWV NNP cord-001397-nrq4ncdf 28 9 and and CC cord-001397-nrq4ncdf 28 10 TBEV TBEV NNP cord-001397-nrq4ncdf 28 11 , , , cord-001397-nrq4ncdf 28 12 alternately alternately RB cord-001397-nrq4ncdf 28 13 infect infect VBP cord-001397-nrq4ncdf 28 14 small small JJ cord-001397-nrq4ncdf 28 15 vertebrates vertebrate NNS cord-001397-nrq4ncdf 28 16 such such JJ cord-001397-nrq4ncdf 28 17 as as IN cord-001397-nrq4ncdf 28 18 rodents rodent NNS cord-001397-nrq4ncdf 28 19 , , , cord-001397-nrq4ncdf 28 20 hares hare NNS cord-001397-nrq4ncdf 28 21 , , , cord-001397-nrq4ncdf 28 22 some some DT cord-001397-nrq4ncdf 28 23 carnivores carnivore NNS cord-001397-nrq4ncdf 28 24 , , , cord-001397-nrq4ncdf 28 25 and and CC cord-001397-nrq4ncdf 28 26 a a DT cord-001397-nrq4ncdf 28 27 range range NN cord-001397-nrq4ncdf 28 28 of of IN cord-001397-nrq4ncdf 28 29 hard hard JJ cord-001397-nrq4ncdf 28 30 - - HYPH cord-001397-nrq4ncdf 28 31 bodied bodied JJ cord-001397-nrq4ncdf 28 32 ( ( -LRB- cord-001397-nrq4ncdf 28 33 ixodid ixodid NN cord-001397-nrq4ncdf 28 34 ) ) -RRB- cord-001397-nrq4ncdf 28 35 ticks tick NNS cord-001397-nrq4ncdf 28 36 , , , cord-001397-nrq4ncdf 28 37 although although IN cord-001397-nrq4ncdf 28 38 recent recent JJ cord-001397-nrq4ncdf 28 39 evidence evidence NN cord-001397-nrq4ncdf 28 40 suggests suggest VBZ cord-001397-nrq4ncdf 28 41 that that IN cord-001397-nrq4ncdf 28 42 the the DT cord-001397-nrq4ncdf 28 43 soft soft JJ cord-001397-nrq4ncdf 28 44 - - HYPH cord-001397-nrq4ncdf 28 45 bodied bodied JJ cord-001397-nrq4ncdf 28 46 Ornithodoros Ornithodoros NNP cord-001397-nrq4ncdf 28 47 ( ( -LRB- cord-001397-nrq4ncdf 28 48 argasid argasid NNP cord-001397-nrq4ncdf 28 49 ) ) -RRB- cord-001397-nrq4ncdf 28 50 ticks tick NNS cord-001397-nrq4ncdf 28 51 can can MD cord-001397-nrq4ncdf 28 52 also also RB cord-001397-nrq4ncdf 28 53 support support VB cord-001397-nrq4ncdf 28 54 TBFV TBFV NNP cord-001397-nrq4ncdf 28 55 ( ( -LRB- cord-001397-nrq4ncdf 28 56 Rajagopalan Rajagopalan NNP cord-001397-nrq4ncdf 28 57 et et NNP cord-001397-nrq4ncdf 28 58 al al NNP cord-001397-nrq4ncdf 28 59 . . NNP cord-001397-nrq4ncdf 28 60 , , , cord-001397-nrq4ncdf 28 61 1969 1969 CD cord-001397-nrq4ncdf 28 62 ; ; : cord-001397-nrq4ncdf 28 63 Charrel Charrel NNP cord-001397-nrq4ncdf 28 64 et et NNP cord-001397-nrq4ncdf 28 65 al al NNP cord-001397-nrq4ncdf 28 66 . . NNP cord-001397-nrq4ncdf 28 67 , , , cord-001397-nrq4ncdf 28 68 2007 2007 CD cord-001397-nrq4ncdf 28 69 ) ) -RRB- cord-001397-nrq4ncdf 28 70 . . . cord-001397-nrq4ncdf 29 1 Similarly similarly RB cord-001397-nrq4ncdf 29 2 , , , cord-001397-nrq4ncdf 29 3 MBFVs mbfv NNS cord-001397-nrq4ncdf 29 4 , , , cord-001397-nrq4ncdf 29 5 such such JJ cord-001397-nrq4ncdf 29 6 as as IN cord-001397-nrq4ncdf 29 7 WNV WNV NNP cord-001397-nrq4ncdf 29 8 and and CC cord-001397-nrq4ncdf 29 9 JEV JEV NNP cord-001397-nrq4ncdf 29 10 , , , cord-001397-nrq4ncdf 29 11 primarily primarily RB cord-001397-nrq4ncdf 29 12 alternate alternate JJ cord-001397-nrq4ncdf 29 13 in in IN cord-001397-nrq4ncdf 29 14 nature nature NN cord-001397-nrq4ncdf 29 15 between between IN cord-001397-nrq4ncdf 29 16 small small JJ cord-001397-nrq4ncdf 29 17 mammals mammal NNS cord-001397-nrq4ncdf 29 18 , , , cord-001397-nrq4ncdf 29 19 birds bird NNS cord-001397-nrq4ncdf 29 20 , , , cord-001397-nrq4ncdf 29 21 and and CC cord-001397-nrq4ncdf 29 22 mosquitoes mosquito NNS cord-001397-nrq4ncdf 29 23 ( ( -LRB- cord-001397-nrq4ncdf 29 24 Fig Fig NNP cord-001397-nrq4ncdf 29 25 . . NNP cord-001397-nrq4ncdf 29 26 1 1 CD cord-001397-nrq4ncdf 29 27 ) ) -RRB- cord-001397-nrq4ncdf 29 28 . . . cord-001397-nrq4ncdf 30 1 In in IN cord-001397-nrq4ncdf 30 2 addition addition NN cord-001397-nrq4ncdf 30 3 , , , cord-001397-nrq4ncdf 30 4 there there EX cord-001397-nrq4ncdf 30 5 is be VBZ cord-001397-nrq4ncdf 30 6 evidence evidence NN cord-001397-nrq4ncdf 30 7 that that IN cord-001397-nrq4ncdf 30 8 MBFV MBFV NNP cord-001397-nrq4ncdf 30 9 and and CC cord-001397-nrq4ncdf 30 10 TBFV TBFV NNP cord-001397-nrq4ncdf 30 11 persistence persistence NN cord-001397-nrq4ncdf 30 12 also also RB cord-001397-nrq4ncdf 30 13 occurs occur VBZ cord-001397-nrq4ncdf 30 14 in in IN cord-001397-nrq4ncdf 30 15 humans human NNS cord-001397-nrq4ncdf 30 16 , , , cord-001397-nrq4ncdf 30 17 and and CC cord-001397-nrq4ncdf 30 18 persistence persistence NN cord-001397-nrq4ncdf 30 19 in in IN cord-001397-nrq4ncdf 30 20 cell cell NN cord-001397-nrq4ncdf 30 21 culture culture NN cord-001397-nrq4ncdf 30 22 is be VBZ cord-001397-nrq4ncdf 30 23 well well RB cord-001397-nrq4ncdf 30 24 documented document VBN cord-001397-nrq4ncdf 30 25 ( ( -LRB- cord-001397-nrq4ncdf 31 1 Poidinger Poidinger NNP cord-001397-nrq4ncdf 31 2 et et NNP cord-001397-nrq4ncdf 31 3 al al NNP cord-001397-nrq4ncdf 31 4 . . NNP cord-001397-nrq4ncdf 31 5 , , , cord-001397-nrq4ncdf 31 6 1991 1991 CD cord-001397-nrq4ncdf 31 7 ; ; : cord-001397-nrq4ncdf 31 8 Lancaster Lancaster NNP cord-001397-nrq4ncdf 31 9 et et NNP cord-001397-nrq4ncdf 31 10 al al NNP cord-001397-nrq4ncdf 31 11 . . NNP cord-001397-nrq4ncdf 31 12 , , , cord-001397-nrq4ncdf 31 13 1998 1998 CD cord-001397-nrq4ncdf 31 14 ; ; : cord-001397-nrq4ncdf 32 1 Bugrysheva Bugrysheva NNP cord-001397-nrq4ncdf 32 2 et et NNP cord-001397-nrq4ncdf 32 3 al al NNP cord-001397-nrq4ncdf 32 4 . . NNP cord-001397-nrq4ncdf 32 5 , , , cord-001397-nrq4ncdf 32 6 2001 2001 CD cord-001397-nrq4ncdf 32 7 ; ; : cord-001397-nrq4ncdf 32 8 Farfan Farfan NNP cord-001397-nrq4ncdf 32 9 - - HYPH cord-001397-nrq4ncdf 32 10 Ale Ale NNP cord-001397-nrq4ncdf 32 11 et et FW cord-001397-nrq4ncdf 32 12 al al NNP cord-001397-nrq4ncdf 32 13 . . . cord-001397-nrq4ncdf 33 1 , , , cord-001397-nrq4ncdf 33 2 2009 2009 CD cord-001397-nrq4ncdf 33 3 ; ; : cord-001397-nrq4ncdf 33 4 Murray Murray NNP cord-001397-nrq4ncdf 33 5 et et NNP cord-001397-nrq4ncdf 33 6 al al NNP cord-001397-nrq4ncdf 33 7 . . NNP cord-001397-nrq4ncdf 33 8 , , , cord-001397-nrq4ncdf 33 9 2010 2010 CD cord-001397-nrq4ncdf 33 10 ) ) -RRB- cord-001397-nrq4ncdf 33 11 . . . cord-001397-nrq4ncdf 34 1 Although although IN cord-001397-nrq4ncdf 34 2 the the DT cord-001397-nrq4ncdf 34 3 hosts host NNS cord-001397-nrq4ncdf 34 4 for for IN cord-001397-nrq4ncdf 34 5 the the DT cord-001397-nrq4ncdf 34 6 VBFVs vbfv NNS cord-001397-nrq4ncdf 34 7 are be VBP cord-001397-nrq4ncdf 34 8 highly highly RB cord-001397-nrq4ncdf 34 9 varied varied JJ cord-001397-nrq4ncdf 34 10 , , , cord-001397-nrq4ncdf 34 11 the the DT cord-001397-nrq4ncdf 34 12 genomic genomic JJ cord-001397-nrq4ncdf 34 13 and and CC cord-001397-nrq4ncdf 34 14 structural structural JJ cord-001397-nrq4ncdf 34 15 organization organization NN cord-001397-nrq4ncdf 34 16 of of IN cord-001397-nrq4ncdf 34 17 the the DT cord-001397-nrq4ncdf 34 18 viruses virus NNS cord-001397-nrq4ncdf 34 19 themselves -PRON- PRP cord-001397-nrq4ncdf 34 20 is be VBZ cord-001397-nrq4ncdf 34 21 remarkably remarkably RB cord-001397-nrq4ncdf 34 22 similar similar JJ cord-001397-nrq4ncdf 34 23 . . . cord-001397-nrq4ncdf 35 1 All all DT cord-001397-nrq4ncdf 35 2 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 35 3 are be VBP cord-001397-nrq4ncdf 35 4 spherical spherical JJ cord-001397-nrq4ncdf 35 5 , , , cord-001397-nrq4ncdf 35 6 enveloped enveloped JJ cord-001397-nrq4ncdf 35 7 particles particle NNS cord-001397-nrq4ncdf 35 8 that that WDT cord-001397-nrq4ncdf 35 9 contain contain VBP cord-001397-nrq4ncdf 35 10 a a DT cord-001397-nrq4ncdf 35 11 genome genome NN cord-001397-nrq4ncdf 35 12 of of IN cord-001397-nrq4ncdf 35 13 ( ( -LRB- cord-001397-nrq4ncdf 35 14 + + NNS cord-001397-nrq4ncdf 35 15 ) ) -RRB- cord-001397-nrq4ncdf 35 16 ssRNA ssRNA VBG cord-001397-nrq4ncdf 35 17 measuring measure VBG cord-001397-nrq4ncdf 35 18 approximately approximately RB cord-001397-nrq4ncdf 35 19 11 11 CD cord-001397-nrq4ncdf 35 20 kb kb NNS cord-001397-nrq4ncdf 35 21 . . . cord-001397-nrq4ncdf 36 1 The the DT cord-001397-nrq4ncdf 36 2 genome genome NN cord-001397-nrq4ncdf 36 3 also also RB cord-001397-nrq4ncdf 36 4 functions function VBZ cord-001397-nrq4ncdf 36 5 as as IN cord-001397-nrq4ncdf 36 6 mRNA mRNA NNP cord-001397-nrq4ncdf 36 7 and and CC cord-001397-nrq4ncdf 36 8 encodes encode VBZ cord-001397-nrq4ncdf 36 9 a a DT cord-001397-nrq4ncdf 36 10 single single JJ cord-001397-nrq4ncdf 36 11 polyprotein polyprotein NN cord-001397-nrq4ncdf 36 12 that that WDT cord-001397-nrq4ncdf 36 13 is be VBZ cord-001397-nrq4ncdf 36 14 cleaved cleave VBN cord-001397-nrq4ncdf 36 15 into into IN cord-001397-nrq4ncdf 36 16 10 10 CD cord-001397-nrq4ncdf 36 17 proteins protein NNS cord-001397-nrq4ncdf 36 18 ( ( -LRB- cord-001397-nrq4ncdf 36 19 Table table NN cord-001397-nrq4ncdf 36 20 1 1 CD cord-001397-nrq4ncdf 36 21 ) ) -RRB- cord-001397-nrq4ncdf 36 22 . . . cord-001397-nrq4ncdf 37 1 Reasonable reasonable JJ cord-001397-nrq4ncdf 37 2 progress progress NN cord-001397-nrq4ncdf 37 3 has have VBZ cord-001397-nrq4ncdf 37 4 been be VBN cord-001397-nrq4ncdf 37 5 made make VBN cord-001397-nrq4ncdf 37 6 toward toward IN cord-001397-nrq4ncdf 37 7 understanding understanding NN cord-001397-nrq4ncdf 37 8 how how WRB cord-001397-nrq4ncdf 37 9 these these DT cord-001397-nrq4ncdf 37 10 viruses virus NNS cord-001397-nrq4ncdf 37 11 replicate replicate VBP cord-001397-nrq4ncdf 38 1 ( ( -LRB- cord-001397-nrq4ncdf 38 2 Chambers Chambers NNP cord-001397-nrq4ncdf 38 3 et et NNP cord-001397-nrq4ncdf 38 4 al al NNP cord-001397-nrq4ncdf 38 5 . . NNP cord-001397-nrq4ncdf 38 6 , , , cord-001397-nrq4ncdf 38 7 1990 1990 CD cord-001397-nrq4ncdf 38 8 ; ; : cord-001397-nrq4ncdf 38 9 Mandl Mandl NNP cord-001397-nrq4ncdf 38 10 , , , cord-001397-nrq4ncdf 38 11 2005 2005 CD cord-001397-nrq4ncdf 39 1 ; ; : cord-001397-nrq4ncdf 39 2 Miorin Miorin NNP cord-001397-nrq4ncdf 39 3 et et NNP cord-001397-nrq4ncdf 39 4 al al NNP cord-001397-nrq4ncdf 39 5 . . NNP cord-001397-nrq4ncdf 39 6 , , , cord-001397-nrq4ncdf 39 7 2008 2008 CD cord-001397-nrq4ncdf 39 8 ; ; : cord-001397-nrq4ncdf 39 9 Tuplin Tuplin NNP cord-001397-nrq4ncdf 39 10 et et NNP cord-001397-nrq4ncdf 39 11 al al NNP cord-001397-nrq4ncdf 39 12 . . NNP cord-001397-nrq4ncdf 39 13 , , , cord-001397-nrq4ncdf 39 14 2011 2011 CD cord-001397-nrq4ncdf 39 15 ; ; : cord-001397-nrq4ncdf 39 16 Pierson Pierson NNP cord-001397-nrq4ncdf 39 17 & & CC cord-001397-nrq4ncdf 39 18 Diamond Diamond NNP cord-001397-nrq4ncdf 39 19 , , , cord-001397-nrq4ncdf 39 20 2012 2012 CD cord-001397-nrq4ncdf 39 21 ; ; : cord-001397-nrq4ncdf 40 1 Brinton Brinton NNP cord-001397-nrq4ncdf 40 2 , , , cord-001397-nrq4ncdf 40 3 2013 2013 CD cord-001397-nrq4ncdf 40 4 ; ; : cord-001397-nrq4ncdf 40 5 Pierson Pierson NNP cord-001397-nrq4ncdf 40 6 & & CC cord-001397-nrq4ncdf 40 7 Kielian Kielian NNP cord-001397-nrq4ncdf 40 8 , , , cord-001397-nrq4ncdf 40 9 2013 2013 CD cord-001397-nrq4ncdf 40 10 ) ) -RRB- cord-001397-nrq4ncdf 40 11 . . . cord-001397-nrq4ncdf 41 1 We -PRON- PRP cord-001397-nrq4ncdf 41 2 present present VBP cord-001397-nrq4ncdf 41 3 a a DT cord-001397-nrq4ncdf 41 4 simplified simplified JJ cord-001397-nrq4ncdf 41 5 overview overview NN cord-001397-nrq4ncdf 41 6 of of IN cord-001397-nrq4ncdf 41 7 the the DT cord-001397-nrq4ncdf 41 8 general general JJ cord-001397-nrq4ncdf 41 9 aspects aspect NNS cord-001397-nrq4ncdf 41 10 of of IN cord-001397-nrq4ncdf 41 11 a a DT cord-001397-nrq4ncdf 41 12 VBFV vbfv NN cord-001397-nrq4ncdf 41 13 replication replication NN cord-001397-nrq4ncdf 41 14 cycle cycle NN cord-001397-nrq4ncdf 41 15 in in IN cord-001397-nrq4ncdf 41 16 Fig Fig NNP cord-001397-nrq4ncdf 41 17 . . . cord-001397-nrq4ncdf 42 1 3 3 LS cord-001397-nrq4ncdf 42 2 . . . cord-001397-nrq4ncdf 43 1 The the DT cord-001397-nrq4ncdf 43 2 individual individual JJ cord-001397-nrq4ncdf 43 3 proteins protein NNS cord-001397-nrq4ncdf 43 4 are be VBP cord-001397-nrq4ncdf 43 5 three three CD cord-001397-nrq4ncdf 43 6 structural structural JJ cord-001397-nrq4ncdf 43 7 proteins protein NNS cord-001397-nrq4ncdf 43 8 : : : cord-001397-nrq4ncdf 43 9 capsid capsid NN cord-001397-nrq4ncdf 43 10 ( ( -LRB- cord-001397-nrq4ncdf 43 11 C C NNP cord-001397-nrq4ncdf 43 12 ) ) -RRB- cord-001397-nrq4ncdf 43 13 , , . cord-001397-nrq4ncdf 44 1 precursor precursor NN cord-001397-nrq4ncdf 44 2 membrane membrane NN cord-001397-nrq4ncdf 44 3 / / SYM cord-001397-nrq4ncdf 44 4 mem- mem- RB cord-001397-nrq4ncdf 45 1 Fig Fig NNP cord-001397-nrq4ncdf 45 2 . . . cord-001397-nrq4ncdf 46 1 1 1 LS cord-001397-nrq4ncdf 47 1 Flavivirus flavivirus JJ cord-001397-nrq4ncdf 47 2 maintenance maintenance NN cord-001397-nrq4ncdf 47 3 and and CC cord-001397-nrq4ncdf 47 4 transmission transmission NN cord-001397-nrq4ncdf 47 5 cycle cycle NN cord-001397-nrq4ncdf 47 6 in in IN cord-001397-nrq4ncdf 47 7 ticks tick NNS cord-001397-nrq4ncdf 47 8 and and CC cord-001397-nrq4ncdf 47 9 vertebrate vertebrate JJ cord-001397-nrq4ncdf 47 10 hosts host NNS cord-001397-nrq4ncdf 47 11 . . . cord-001397-nrq4ncdf 48 1 Ticks tick NNS cord-001397-nrq4ncdf 48 2 are be VBP cord-001397-nrq4ncdf 48 3 crucial crucial JJ cord-001397-nrq4ncdf 48 4 for for IN cord-001397-nrq4ncdf 48 5 viral viral JJ cord-001397-nrq4ncdf 48 6 persistence persistence NN cord-001397-nrq4ncdf 48 7 as as IN cord-001397-nrq4ncdf 48 8 they -PRON- PRP cord-001397-nrq4ncdf 48 9 remain remain VBP cord-001397-nrq4ncdf 48 10 infected infected JJ cord-001397-nrq4ncdf 48 11 once once IN cord-001397-nrq4ncdf 48 12 they -PRON- PRP cord-001397-nrq4ncdf 48 13 acquire acquire VBP cord-001397-nrq4ncdf 48 14 viral viral JJ cord-001397-nrq4ncdf 48 15 infection infection NN cord-001397-nrq4ncdf 48 16 . . . cord-001397-nrq4ncdf 49 1 Infected infected JJ cord-001397-nrq4ncdf 49 2 ticks tick NNS cord-001397-nrq4ncdf 49 3 are be VBP cord-001397-nrq4ncdf 49 4 capable capable JJ cord-001397-nrq4ncdf 49 5 of of IN cord-001397-nrq4ncdf 49 6 transmitting transmit VBG cord-001397-nrq4ncdf 49 7 TBFVs tbfvs IN cord-001397-nrq4ncdf 49 8 to to IN cord-001397-nrq4ncdf 49 9 other other JJ cord-001397-nrq4ncdf 49 10 ticks tick NNS cord-001397-nrq4ncdf 49 11 when when WRB cord-001397-nrq4ncdf 49 12 they -PRON- PRP cord-001397-nrq4ncdf 49 13 feed feed VBP cord-001397-nrq4ncdf 49 14 in in IN cord-001397-nrq4ncdf 49 15 close close JJ cord-001397-nrq4ncdf 49 16 proximity proximity NN cord-001397-nrq4ncdf 49 17 on on IN cord-001397-nrq4ncdf 49 18 the the DT cord-001397-nrq4ncdf 49 19 same same JJ cord-001397-nrq4ncdf 49 20 animal animal NN cord-001397-nrq4ncdf 49 21 , , , cord-001397-nrq4ncdf 49 22 as as RB cord-001397-nrq4ncdf 49 23 well well RB cord-001397-nrq4ncdf 49 24 as as IN cord-001397-nrq4ncdf 49 25 the the DT cord-001397-nrq4ncdf 49 26 different different JJ cord-001397-nrq4ncdf 49 27 stages stage NNS cord-001397-nrq4ncdf 49 28 of of IN cord-001397-nrq4ncdf 49 29 the the DT cord-001397-nrq4ncdf 49 30 tick tick NN cord-001397-nrq4ncdf 49 31 life life NN cord-001397-nrq4ncdf 49 32 cycle cycle NN cord-001397-nrq4ncdf 49 33 . . . cord-001397-nrq4ncdf 50 1 TBFVs tbfv NNS cord-001397-nrq4ncdf 50 2 persist persist VBP cord-001397-nrq4ncdf 50 3 also also RB cord-001397-nrq4ncdf 50 4 in in IN cord-001397-nrq4ncdf 50 5 a a DT cord-001397-nrq4ncdf 50 6 cycle cycle NN cord-001397-nrq4ncdf 50 7 between between IN cord-001397-nrq4ncdf 50 8 small small JJ cord-001397-nrq4ncdf 50 9 mammals mammal NNS cord-001397-nrq4ncdf 50 10 ( ( -LRB- cord-001397-nrq4ncdf 50 11 e.g. e.g. IN cord-001397-nrq4ncdf 50 12 rodents rodent NNS cord-001397-nrq4ncdf 50 13 ) ) -RRB- cord-001397-nrq4ncdf 50 14 and and CC cord-001397-nrq4ncdf 50 15 the the DT cord-001397-nrq4ncdf 50 16 ticks tick NNS cord-001397-nrq4ncdf 50 17 that that WDT cord-001397-nrq4ncdf 50 18 feed feed VBP cord-001397-nrq4ncdf 50 19 on on IN cord-001397-nrq4ncdf 50 20 them -PRON- PRP cord-001397-nrq4ncdf 50 21 . . . cord-001397-nrq4ncdf 51 1 Large large JJ cord-001397-nrq4ncdf 51 2 mammals mammal NNS cord-001397-nrq4ncdf 51 3 and and CC cord-001397-nrq4ncdf 51 4 humans human NNS cord-001397-nrq4ncdf 51 5 tend tend VBP cord-001397-nrq4ncdf 51 6 to to TO cord-001397-nrq4ncdf 51 7 be be VB cord-001397-nrq4ncdf 51 8 incidental incidental JJ cord-001397-nrq4ncdf 51 9 , , , cord-001397-nrq4ncdf 51 10 dead dead JJ cord-001397-nrq4ncdf 51 11 - - HYPH cord-001397-nrq4ncdf 51 12 end end NN cord-001397-nrq4ncdf 51 13 hosts host NNS cord-001397-nrq4ncdf 51 14 . . . cord-001397-nrq4ncdf 52 1 Fig Fig NNP cord-001397-nrq4ncdf 52 2 . . . cord-001397-nrq4ncdf 53 1 2 2 LS cord-001397-nrq4ncdf 54 1 A a DT cord-001397-nrq4ncdf 54 2 representation representation NN cord-001397-nrq4ncdf 54 3 of of IN cord-001397-nrq4ncdf 54 4 a a DT cord-001397-nrq4ncdf 54 5 mosquito mosquito NN cord-001397-nrq4ncdf 54 6 - - HYPH cord-001397-nrq4ncdf 54 7 borne bear VBN cord-001397-nrq4ncdf 54 8 flavivirus flavivirus JJ cord-001397-nrq4ncdf 54 9 amplification amplification NN cord-001397-nrq4ncdf 54 10 and and CC cord-001397-nrq4ncdf 54 11 transmission transmission NN cord-001397-nrq4ncdf 54 12 cycle cycle NN cord-001397-nrq4ncdf 54 13 . . . cord-001397-nrq4ncdf 55 1 WNV WNV NNP cord-001397-nrq4ncdf 55 2 is be VBZ cord-001397-nrq4ncdf 55 3 cycled cycle VBN cord-001397-nrq4ncdf 55 4 between between IN cord-001397-nrq4ncdf 55 5 the the DT cord-001397-nrq4ncdf 55 6 mosquito mosquito NN cord-001397-nrq4ncdf 55 7 and and CC cord-001397-nrq4ncdf 55 8 avian avian JJ cord-001397-nrq4ncdf 55 9 hosts host NNS cord-001397-nrq4ncdf 55 10 that that WDT cord-001397-nrq4ncdf 55 11 play play VBP cord-001397-nrq4ncdf 55 12 an an DT cord-001397-nrq4ncdf 55 13 amplification amplification NN cord-001397-nrq4ncdf 55 14 and and CC cord-001397-nrq4ncdf 55 15 maintenance maintenance NN cord-001397-nrq4ncdf 55 16 role role NN cord-001397-nrq4ncdf 55 17 . . . cord-001397-nrq4ncdf 56 1 Swine Swine NNS cord-001397-nrq4ncdf 56 2 are be VBP cord-001397-nrq4ncdf 56 3 important important JJ cord-001397-nrq4ncdf 56 4 amplifying amplify VBG cord-001397-nrq4ncdf 56 5 hosts host NNS cord-001397-nrq4ncdf 56 6 for for IN cord-001397-nrq4ncdf 56 7 JEV JEV NNP cord-001397-nrq4ncdf 56 8 , , , cord-001397-nrq4ncdf 56 9 and and CC cord-001397-nrq4ncdf 56 10 mosquitoes mosquito NNS cord-001397-nrq4ncdf 56 11 that that WDT cord-001397-nrq4ncdf 56 12 acquire acquire VBP cord-001397-nrq4ncdf 56 13 blood blood NN cord-001397-nrq4ncdf 56 14 meals meal NNS cord-001397-nrq4ncdf 56 15 on on IN cord-001397-nrq4ncdf 56 16 infected infected JJ cord-001397-nrq4ncdf 56 17 pigs pig NNS cord-001397-nrq4ncdf 56 18 can can MD cord-001397-nrq4ncdf 56 19 become become VB cord-001397-nrq4ncdf 56 20 infected infected JJ cord-001397-nrq4ncdf 56 21 and and CC cord-001397-nrq4ncdf 56 22 transmit transmit VB cord-001397-nrq4ncdf 56 23 the the DT cord-001397-nrq4ncdf 56 24 virus virus NN cord-001397-nrq4ncdf 56 25 . . . cord-001397-nrq4ncdf 57 1 Similar similar JJ cord-001397-nrq4ncdf 57 2 to to IN cord-001397-nrq4ncdf 57 3 TBFVs tbfv NNS cord-001397-nrq4ncdf 57 4 , , , cord-001397-nrq4ncdf 57 5 MBFV MBFV NNP cord-001397-nrq4ncdf 57 6 infection infection NN cord-001397-nrq4ncdf 57 7 in in IN cord-001397-nrq4ncdf 57 8 humans human NNS cord-001397-nrq4ncdf 57 9 and and CC cord-001397-nrq4ncdf 57 10 large large JJ cord-001397-nrq4ncdf 57 11 animals animal NNS cord-001397-nrq4ncdf 57 12 , , , cord-001397-nrq4ncdf 57 13 such such JJ cord-001397-nrq4ncdf 57 14 as as IN cord-001397-nrq4ncdf 57 15 horses horse NNS cord-001397-nrq4ncdf 57 16 , , , cord-001397-nrq4ncdf 57 17 is be VBZ cord-001397-nrq4ncdf 57 18 accidental accidental JJ cord-001397-nrq4ncdf 57 19 . . . cord-001397-nrq4ncdf 58 1 The the DT cord-001397-nrq4ncdf 58 2 flavivirus flavivirus JJ cord-001397-nrq4ncdf 58 3 proteins protein NNS cord-001397-nrq4ncdf 58 4 , , , cord-001397-nrq4ncdf 58 5 untranslated untranslated JJ cord-001397-nrq4ncdf 58 6 regions region NNS cord-001397-nrq4ncdf 58 7 ( ( -LRB- cord-001397-nrq4ncdf 58 8 UTRs UTRs NNP cord-001397-nrq4ncdf 58 9 ) ) -RRB- cord-001397-nrq4ncdf 58 10 , , , cord-001397-nrq4ncdf 58 11 and and CC cord-001397-nrq4ncdf 58 12 their -PRON- PRP$ cord-001397-nrq4ncdf 58 13 known know VBN cord-001397-nrq4ncdf 58 14 functions function NNS cord-001397-nrq4ncdf 58 15 The the DT cord-001397-nrq4ncdf 58 16 5 5 CD cord-001397-nrq4ncdf 58 17 0 0 CD cord-001397-nrq4ncdf 59 1 UTR UTR NNP cord-001397-nrq4ncdf 59 2 contains contain VBZ cord-001397-nrq4ncdf 59 3 conserved conserve VBN cord-001397-nrq4ncdf 59 4 RNA RNA NNP cord-001397-nrq4ncdf 59 5 stem stem NN cord-001397-nrq4ncdf 59 6 loops loop NNS cord-001397-nrq4ncdf 59 7 ( ( -LRB- cord-001397-nrq4ncdf 59 8 SL SL NNP cord-001397-nrq4ncdf 59 9 ) ) -RRB- cord-001397-nrq4ncdf 59 10 , , , cord-001397-nrq4ncdf 59 11 cis cis NNP cord-001397-nrq4ncdf 59 12 - - HYPH cord-001397-nrq4ncdf 59 13 elements element NNS cord-001397-nrq4ncdf 59 14 located locate VBN cord-001397-nrq4ncdf 59 15 upstream upstream RB cord-001397-nrq4ncdf 59 16 and and CC cord-001397-nrq4ncdf 59 17 downstream downstream RB cord-001397-nrq4ncdf 59 18 of of IN cord-001397-nrq4ncdf 59 19 the the DT cord-001397-nrq4ncdf 59 20 AUG AUG NNP cord-001397-nrq4ncdf 59 21 region region NN cord-001397-nrq4ncdf 59 22 ( ( -LRB- cord-001397-nrq4ncdf 59 23 UAR UAR NNP cord-001397-nrq4ncdf 59 24 and and CC cord-001397-nrq4ncdf 59 25 DAR DAR NNP cord-001397-nrq4ncdf 59 26 , , , cord-001397-nrq4ncdf 59 27 respectively respectively RB cord-001397-nrq4ncdf 59 28 ) ) -RRB- cord-001397-nrq4ncdf 59 29 , , , cord-001397-nrq4ncdf 59 30 and and CC cord-001397-nrq4ncdf 59 31 complementary complementary JJ cord-001397-nrq4ncdf 59 32 sequence sequence NN cord-001397-nrq4ncdf 59 33 ( ( -LRB- cord-001397-nrq4ncdf 59 34 CS CS NNP cord-001397-nrq4ncdf 59 35 ) ) -RRB- cord-001397-nrq4ncdf 59 36 sponsoring sponsor VBG cord-001397-nrq4ncdf 59 37 cyclization cyclization NN cord-001397-nrq4ncdf 59 38 of of IN cord-001397-nrq4ncdf 59 39 the the DT cord-001397-nrq4ncdf 59 40 genome genome NN cord-001397-nrq4ncdf 59 41 by by IN cord-001397-nrq4ncdf 59 42 interacting interact VBG cord-001397-nrq4ncdf 59 43 with with IN cord-001397-nrq4ncdf 59 44 the the DT cord-001397-nrq4ncdf 59 45 3 3 CD cord-001397-nrq4ncdf 59 46 0 0 CD cord-001397-nrq4ncdf 59 47 UTR UTR NNP cord-001397-nrq4ncdf 59 48 to to TO cord-001397-nrq4ncdf 59 49 form form VB cord-001397-nrq4ncdf 59 50 a a DT cord-001397-nrq4ncdf 59 51 ' ' `` cord-001397-nrq4ncdf 59 52 panhandle panhandle NN cord-001397-nrq4ncdf 59 53 ' ' '' cord-001397-nrq4ncdf 59 54 ( ( -LRB- cord-001397-nrq4ncdf 59 55 Alvarez Alvarez NNP cord-001397-nrq4ncdf 59 56 et et NNP cord-001397-nrq4ncdf 59 57 al al NNP cord-001397-nrq4ncdf 59 58 . . NNP cord-001397-nrq4ncdf 59 59 , , , cord-001397-nrq4ncdf 59 60 2005 2005 CD cord-001397-nrq4ncdf 59 61 ; ; : cord-001397-nrq4ncdf 59 62 Villordo Villordo NNP cord-001397-nrq4ncdf 59 63 & & CC cord-001397-nrq4ncdf 59 64 Gamarnik Gamarnik NNP cord-001397-nrq4ncdf 59 65 , , , cord-001397-nrq4ncdf 59 66 2009 2009 CD cord-001397-nrq4ncdf 59 67 ; ; : cord-001397-nrq4ncdf 59 68 Friebe Friebe NNP cord-001397-nrq4ncdf 59 69 & & CC cord-001397-nrq4ncdf 59 70 Harris Harris NNP cord-001397-nrq4ncdf 59 71 , , , cord-001397-nrq4ncdf 59 72 2010 2010 CD cord-001397-nrq4ncdf 59 73 ; ; : cord-001397-nrq4ncdf 59 74 Friebe Friebe NNP cord-001397-nrq4ncdf 59 75 et et FW cord-001397-nrq4ncdf 59 76 al al NNP cord-001397-nrq4ncdf 59 77 . . NNP cord-001397-nrq4ncdf 59 78 , , , cord-001397-nrq4ncdf 59 79 2011 2011 CD cord-001397-nrq4ncdf 59 80 ) ) -RRB- cord-001397-nrq4ncdf 59 81 . . . cord-001397-nrq4ncdf 60 1 The the DT cord-001397-nrq4ncdf 60 2 ' ' `` cord-001397-nrq4ncdf 60 3 panhandle panhandle NN cord-001397-nrq4ncdf 60 4 ' ' '' cord-001397-nrq4ncdf 60 5 structure structure NN cord-001397-nrq4ncdf 60 6 is be VBZ cord-001397-nrq4ncdf 60 7 essential essential JJ cord-001397-nrq4ncdf 60 8 for for IN cord-001397-nrq4ncdf 60 9 certain certain JJ cord-001397-nrq4ncdf 60 10 steps step NNS cord-001397-nrq4ncdf 60 11 in in IN cord-001397-nrq4ncdf 60 12 the the DT cord-001397-nrq4ncdf 60 13 flavivirus flavivirus JJ cord-001397-nrq4ncdf 60 14 replication replication NN cord-001397-nrq4ncdf 60 15 cycle cycle NN cord-001397-nrq4ncdf 60 16 such such JJ cord-001397-nrq4ncdf 60 17 as as IN cord-001397-nrq4ncdf 60 18 replication replication NN cord-001397-nrq4ncdf 60 19 / / SYM cord-001397-nrq4ncdf 60 20 translation translation NN cord-001397-nrq4ncdf 60 21 and and CC cord-001397-nrq4ncdf 60 22 viral viral JJ cord-001397-nrq4ncdf 60 23 assembly assembly NN cord-001397-nrq4ncdf 60 24 ( ( -LRB- cord-001397-nrq4ncdf 60 25 Gritsun Gritsun NNP cord-001397-nrq4ncdf 60 26 & & CC cord-001397-nrq4ncdf 60 27 Gould Gould NNP cord-001397-nrq4ncdf 60 28 , , , cord-001397-nrq4ncdf 60 29 2007b 2007b CD cord-001397-nrq4ncdf 60 30 ) ) -RRB- cord-001397-nrq4ncdf 60 31 . . . cord-001397-nrq4ncdf 61 1 SL1 SL1 NNP cord-001397-nrq4ncdf 61 2 - - HYPH cord-001397-nrq4ncdf 61 3 2 2 NNP cord-001397-nrq4ncdf 61 4 or or CC cord-001397-nrq4ncdf 61 5 ( ( -LRB- cord-001397-nrq4ncdf 61 6 SL SL NNP cord-001397-nrq4ncdf 61 7 - - HYPH cord-001397-nrq4ncdf 61 8 A A NNP cord-001397-nrq4ncdf 61 9 and and CC cord-001397-nrq4ncdf 61 10 SL sl NN cord-001397-nrq4ncdf 61 11 - - HYPH cord-001397-nrq4ncdf 61 12 B B NNP cord-001397-nrq4ncdf 61 13 ) ) -RRB- cord-001397-nrq4ncdf 61 14 is be VBZ cord-001397-nrq4ncdf 61 15 located locate VBN cord-001397-nrq4ncdf 61 16 within within IN cord-001397-nrq4ncdf 61 17 the the DT cord-001397-nrq4ncdf 61 18 5 5 CD cord-001397-nrq4ncdf 61 19 0 0 CD cord-001397-nrq4ncdf 61 20 UTR UTR NNP cord-001397-nrq4ncdf 61 21 , , , cord-001397-nrq4ncdf 61 22 whereas whereas IN cord-001397-nrq4ncdf 61 23 the the DT cord-001397-nrq4ncdf 61 24 SL3 SL3 NNP cord-001397-nrq4ncdf 61 25 - - HYPH cord-001397-nrq4ncdf 61 26 4 4 NNP cord-001397-nrq4ncdf 61 27 is be VBZ cord-001397-nrq4ncdf 61 28 extended extend VBN cord-001397-nrq4ncdf 61 29 and and CC cord-001397-nrq4ncdf 61 30 situated situate VBN cord-001397-nrq4ncdf 61 31 in in IN cord-001397-nrq4ncdf 61 32 the the DT cord-001397-nrq4ncdf 61 33 N n CD cord-001397-nrq4ncdf 61 34 - - HYPH cord-001397-nrq4ncdf 61 35 terminal terminal NN cord-001397-nrq4ncdf 61 36 of of IN cord-001397-nrq4ncdf 61 37 the the DT cord-001397-nrq4ncdf 61 38 open open JJ cord-001397-nrq4ncdf 61 39 reading reading NN cord-001397-nrq4ncdf 61 40 frame frame NN cord-001397-nrq4ncdf 61 41 ORF ORF NNP cord-001397-nrq4ncdf 61 42 ( ( -LRB- cord-001397-nrq4ncdf 61 43 Alvarez Alvarez NNP cord-001397-nrq4ncdf 61 44 et et NNP cord-001397-nrq4ncdf 61 45 al al NNP cord-001397-nrq4ncdf 61 46 . . NNP cord-001397-nrq4ncdf 61 47 , , , cord-001397-nrq4ncdf 61 48 2005 2005 CD cord-001397-nrq4ncdf 61 49 ; ; : cord-001397-nrq4ncdf 61 50 Lodeiro Lodeiro NNP cord-001397-nrq4ncdf 61 51 et et FW cord-001397-nrq4ncdf 61 52 al al NNP cord-001397-nrq4ncdf 61 53 . . NNP cord-001397-nrq4ncdf 61 54 , , , cord-001397-nrq4ncdf 61 55 2009 2009 CD cord-001397-nrq4ncdf 61 56 ; ; : cord-001397-nrq4ncdf 61 57 Villordo Villordo NNP cord-001397-nrq4ncdf 61 58 & & CC cord-001397-nrq4ncdf 61 59 Gamarnik Gamarnik NNP cord-001397-nrq4ncdf 61 60 , , , cord-001397-nrq4ncdf 61 61 2009 2009 CD cord-001397-nrq4ncdf 61 62 ; ; : cord-001397-nrq4ncdf 61 63 Friebe Friebe NNP cord-001397-nrq4ncdf 61 64 & & CC cord-001397-nrq4ncdf 61 65 Harris Harris NNP cord-001397-nrq4ncdf 61 66 , , , cord-001397-nrq4ncdf 61 67 2010 2010 CD cord-001397-nrq4ncdf 61 68 ; ; : cord-001397-nrq4ncdf 61 69 Friebe Friebe NNP cord-001397-nrq4ncdf 61 70 et et FW cord-001397-nrq4ncdf 61 71 al al NNP cord-001397-nrq4ncdf 61 72 . . NNP cord-001397-nrq4ncdf 61 73 , , , cord-001397-nrq4ncdf 61 74 2011 2011 CD cord-001397-nrq4ncdf 61 75 ) ) -RRB- cord-001397-nrq4ncdf 61 76 . . . cord-001397-nrq4ncdf 62 1 The the DT cord-001397-nrq4ncdf 62 2 SL1 SL1 NNP cord-001397-nrq4ncdf 62 3 structure structure NN cord-001397-nrq4ncdf 62 4 is be VBZ cord-001397-nrq4ncdf 62 5 essential essential JJ cord-001397-nrq4ncdf 62 6 for for IN cord-001397-nrq4ncdf 62 7 viral viral JJ cord-001397-nrq4ncdf 62 8 replication replication NN cord-001397-nrq4ncdf 62 9 and and CC cord-001397-nrq4ncdf 62 10 acts act VBZ cord-001397-nrq4ncdf 62 11 as as IN cord-001397-nrq4ncdf 62 12 a a DT cord-001397-nrq4ncdf 62 13 promoter promoter NN cord-001397-nrq4ncdf 62 14 which which WDT cord-001397-nrq4ncdf 62 15 is be VBZ cord-001397-nrq4ncdf 62 16 targeted target VBN cord-001397-nrq4ncdf 62 17 initially initially RB cord-001397-nrq4ncdf 62 18 by by IN cord-001397-nrq4ncdf 62 19 NS5 NS5 NNP cord-001397-nrq4ncdf 62 20 and and CC cord-001397-nrq4ncdf 62 21 then then RB cord-001397-nrq4ncdf 62 22 delivered deliver VBD cord-001397-nrq4ncdf 62 23 to to IN cord-001397-nrq4ncdf 62 24 the the DT cord-001397-nrq4ncdf 62 25 3 3 CD cord-001397-nrq4ncdf 62 26 0 0 CD cord-001397-nrq4ncdf 62 27 end end NN cord-001397-nrq4ncdf 62 28 via via IN cord-001397-nrq4ncdf 62 29 cyclization cyclization NN cord-001397-nrq4ncdf 62 30 ( ( -LRB- cord-001397-nrq4ncdf 62 31 Filomatori Filomatori NNP cord-001397-nrq4ncdf 62 32 et et NNP cord-001397-nrq4ncdf 62 33 al al NNP cord-001397-nrq4ncdf 62 34 . . NNP cord-001397-nrq4ncdf 62 35 , , , cord-001397-nrq4ncdf 62 36 2006 2006 CD cord-001397-nrq4ncdf 62 37 ; ; : cord-001397-nrq4ncdf 62 38 Zhang Zhang NNP cord-001397-nrq4ncdf 62 39 et et NNP cord-001397-nrq4ncdf 62 40 al al NNP cord-001397-nrq4ncdf 62 41 . . NNP cord-001397-nrq4ncdf 62 42 , , , cord-001397-nrq4ncdf 62 43 2008 2008 CD cord-001397-nrq4ncdf 62 44 ; ; . cord-001397-nrq4ncdf 63 1 Lodeiro Lodeiro NNP cord-001397-nrq4ncdf 63 2 et et FW cord-001397-nrq4ncdf 63 3 al al NNP cord-001397-nrq4ncdf 63 4 . . NNP cord-001397-nrq4ncdf 63 5 , , , cord-001397-nrq4ncdf 63 6 2009 2009 CD cord-001397-nrq4ncdf 63 7 ) ) -RRB- cord-001397-nrq4ncdf 64 1 Although although IN cord-001397-nrq4ncdf 64 2 there there EX cord-001397-nrq4ncdf 64 3 is be VBZ cord-001397-nrq4ncdf 64 4 low low JJ cord-001397-nrq4ncdf 64 5 nucleotide nucleotide JJ cord-001397-nrq4ncdf 64 6 conservation conservation NN cord-001397-nrq4ncdf 64 7 between between IN cord-001397-nrq4ncdf 64 8 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 64 9 and and CC cord-001397-nrq4ncdf 64 10 different different JJ cord-001397-nrq4ncdf 64 11 CS CS NNP cord-001397-nrq4ncdf 64 12 homology homology NN cord-001397-nrq4ncdf 64 13 ( ( -LRB- cord-001397-nrq4ncdf 64 14 Hahn Hahn NNP cord-001397-nrq4ncdf 64 15 et et NNP cord-001397-nrq4ncdf 64 16 al al NNP cord-001397-nrq4ncdf 64 17 . . NNP cord-001397-nrq4ncdf 64 18 , , , cord-001397-nrq4ncdf 64 19 1987 1987 CD cord-001397-nrq4ncdf 64 20 ) ) -RRB- cord-001397-nrq4ncdf 64 21 , , , cord-001397-nrq4ncdf 64 22 the the DT cord-001397-nrq4ncdf 64 23 5 5 CD cord-001397-nrq4ncdf 64 24 0 0 CD cord-001397-nrq4ncdf 64 25 UTRs utr NNS cord-001397-nrq4ncdf 64 26 of of IN cord-001397-nrq4ncdf 64 27 TBFVs tbfvs JJ cord-001397-nrq4ncdf 64 28 share share VBP cord-001397-nrq4ncdf 64 29 the the DT cord-001397-nrq4ncdf 64 30 same same JJ cord-001397-nrq4ncdf 64 31 genomic genomic JJ cord-001397-nrq4ncdf 64 32 organization organization NN cord-001397-nrq4ncdf 64 33 as as IN cord-001397-nrq4ncdf 64 34 the the DT cord-001397-nrq4ncdf 64 35 MBFVs mbfv NNS cord-001397-nrq4ncdf 65 1 ( ( -LRB- cord-001397-nrq4ncdf 65 2 Kofler Kofler NNP cord-001397-nrq4ncdf 65 3 et et NNP cord-001397-nrq4ncdf 65 4 al al NNP cord-001397-nrq4ncdf 65 5 . . NNP cord-001397-nrq4ncdf 65 6 , , , cord-001397-nrq4ncdf 65 7 2006 2006 CD cord-001397-nrq4ncdf 65 8 ) ) -RRB- cord-001397-nrq4ncdf 66 1 Structural structural JJ cord-001397-nrq4ncdf 66 2 proteins protein NNS cord-001397-nrq4ncdf 67 1 Capsid Capsid NNP cord-001397-nrq4ncdf 67 2 ( ( -LRB- cord-001397-nrq4ncdf 67 3 C C NNP cord-001397-nrq4ncdf 67 4 ) ) -RRB- cord-001397-nrq4ncdf 67 5 11 11 CD cord-001397-nrq4ncdf 67 6 kDa kDa NNS cord-001397-nrq4ncdf 67 7 , , , cord-001397-nrq4ncdf 67 8 114 114 CD cord-001397-nrq4ncdf 67 9 aa aa NNP cord-001397-nrq4ncdf 67 10 Cytosol Cytosol NNP cord-001397-nrq4ncdf 67 11 / / SYM cord-001397-nrq4ncdf 67 12 nucleus nucleus NN cord-001397-nrq4ncdf 68 1 The the DT cord-001397-nrq4ncdf 68 2 capsid capsid JJ cord-001397-nrq4ncdf 68 3 protein protein NN cord-001397-nrq4ncdf 68 4 is be VBZ cord-001397-nrq4ncdf 68 5 a a DT cord-001397-nrq4ncdf 68 6 dimeric dimeric JJ cord-001397-nrq4ncdf 68 7 alpha alpha NN cord-001397-nrq4ncdf 68 8 - - HYPH cord-001397-nrq4ncdf 68 9 helical helical JJ cord-001397-nrq4ncdf 68 10 ( ( -LRB- cord-001397-nrq4ncdf 68 11 Jones Jones NNP cord-001397-nrq4ncdf 68 12 et et NNP cord-001397-nrq4ncdf 68 13 al al NNP cord-001397-nrq4ncdf 68 14 . . NNP cord-001397-nrq4ncdf 68 15 , , , cord-001397-nrq4ncdf 68 16 2003 2003 CD cord-001397-nrq4ncdf 68 17 ) ) -RRB- cord-001397-nrq4ncdf 68 18 protein protein NN cord-001397-nrq4ncdf 68 19 and and CC cord-001397-nrq4ncdf 68 20 assembles assemble VBZ cord-001397-nrq4ncdf 68 21 into into IN cord-001397-nrq4ncdf 68 22 an an DT cord-001397-nrq4ncdf 68 23 icosahedral icosahedral JJ cord-001397-nrq4ncdf 68 24 structure structure NN cord-001397-nrq4ncdf 68 25 , , , cord-001397-nrq4ncdf 68 26 measuring measure VBG cord-001397-nrq4ncdf 68 27 30 30 CD cord-001397-nrq4ncdf 68 28 nm nm NN cord-001397-nrq4ncdf 68 29 in in IN cord-001397-nrq4ncdf 68 30 diameter diameter NN cord-001397-nrq4ncdf 68 31 , , , cord-001397-nrq4ncdf 68 32 which which WDT cord-001397-nrq4ncdf 68 33 initiates initiate VBZ cord-001397-nrq4ncdf 68 34 encapsidation encapsidation NN cord-001397-nrq4ncdf 68 35 of of IN cord-001397-nrq4ncdf 68 36 the the DT cord-001397-nrq4ncdf 68 37 associated associated JJ cord-001397-nrq4ncdf 68 38 genomic genomic JJ cord-001397-nrq4ncdf 68 39 RNA RNA NNP cord-001397-nrq4ncdf 68 40 in in IN cord-001397-nrq4ncdf 68 41 virus virus NN cord-001397-nrq4ncdf 68 42 - - HYPH cord-001397-nrq4ncdf 68 43 induced induce VBN cord-001397-nrq4ncdf 68 44 membrane membrane NN cord-001397-nrq4ncdf 68 45 invaginations invagination NNS cord-001397-nrq4ncdf 68 46 of of IN cord-001397-nrq4ncdf 68 47 the the DT cord-001397-nrq4ncdf 68 48 ER ER NNP cord-001397-nrq4ncdf 68 49 ( ( -LRB- cord-001397-nrq4ncdf 68 50 Welsch Welsch NNP cord-001397-nrq4ncdf 68 51 et et NNP cord-001397-nrq4ncdf 68 52 al al NNP cord-001397-nrq4ncdf 68 53 . . NNP cord-001397-nrq4ncdf 68 54 , , , cord-001397-nrq4ncdf 68 55 2009 2009 CD cord-001397-nrq4ncdf 68 56 ) ) -RRB- cord-001397-nrq4ncdf 68 57 . . . cord-001397-nrq4ncdf 69 1 The the DT cord-001397-nrq4ncdf 69 2 C C NNP cord-001397-nrq4ncdf 69 3 protein protein NN cord-001397-nrq4ncdf 69 4 is be VBZ cord-001397-nrq4ncdf 69 5 also also RB cord-001397-nrq4ncdf 69 6 a a DT cord-001397-nrq4ncdf 69 7 pro pro JJ cord-001397-nrq4ncdf 69 8 - - JJ cord-001397-nrq4ncdf 69 9 apoptotic apoptotic JJ cord-001397-nrq4ncdf 69 10 factor factor NN cord-001397-nrq4ncdf 69 11 in in IN cord-001397-nrq4ncdf 69 12 various various JJ cord-001397-nrq4ncdf 69 13 cell cell NN cord-001397-nrq4ncdf 69 14 lines line NNS cord-001397-nrq4ncdf 69 15 ( ( -LRB- cord-001397-nrq4ncdf 69 16 Yang Yang NNP cord-001397-nrq4ncdf 69 17 et et NNP cord-001397-nrq4ncdf 69 18 al al NNP cord-001397-nrq4ncdf 69 19 . . NNP cord-001397-nrq4ncdf 69 20 , , , cord-001397-nrq4ncdf 69 21 2002 2002 CD cord-001397-nrq4ncdf 70 1 ( ( -LRB- cord-001397-nrq4ncdf 70 2 Yang Yang NNP cord-001397-nrq4ncdf 70 3 et et NNP cord-001397-nrq4ncdf 70 4 al al NNP cord-001397-nrq4ncdf 70 5 . . . cord-001397-nrq4ncdf 71 1 , , , cord-001397-nrq4ncdf 72 1 , , , cord-001397-nrq4ncdf 72 2 2008 2008 CD cord-001397-nrq4ncdf 73 1 Oh oh UH cord-001397-nrq4ncdf 73 2 et et FW cord-001397-nrq4ncdf 73 3 al al NNP cord-001397-nrq4ncdf 73 4 . . NNP cord-001397-nrq4ncdf 73 5 , , , cord-001397-nrq4ncdf 73 6 2006 2006 CD cord-001397-nrq4ncdf 74 1 ; ; : cord-001397-nrq4ncdf 74 2 Netsawang Netsawang NNP cord-001397-nrq4ncdf 74 3 et et NNP cord-001397-nrq4ncdf 74 4 al al NNP cord-001397-nrq4ncdf 74 5 . . NNP cord-001397-nrq4ncdf 74 6 , , , cord-001397-nrq4ncdf 74 7 2010 2010 CD cord-001397-nrq4ncdf 74 8 ; ; : cord-001397-nrq4ncdf 74 9 Morchang Morchang NNP cord-001397-nrq4ncdf 74 10 et et NNP cord-001397-nrq4ncdf 74 11 al al NNP cord-001397-nrq4ncdf 74 12 . . NNP cord-001397-nrq4ncdf 74 13 , , , cord-001397-nrq4ncdf 74 14 2011 2011 CD cord-001397-nrq4ncdf 74 15 ) ) -RRB- cord-001397-nrq4ncdf 74 16 . . . cord-001397-nrq4ncdf 75 1 C C NNP cord-001397-nrq4ncdf 75 2 of of IN cord-001397-nrq4ncdf 75 3 JEV JEV NNP cord-001397-nrq4ncdf 75 4 was be VBD cord-001397-nrq4ncdf 75 5 reported report VBN cord-001397-nrq4ncdf 75 6 to to TO cord-001397-nrq4ncdf 75 7 limit limit VB cord-001397-nrq4ncdf 75 8 viral viral JJ cord-001397-nrq4ncdf 75 9 neurovirulence neurovirulence NN cord-001397-nrq4ncdf 75 10 ( ( -LRB- cord-001397-nrq4ncdf 75 11 Mori Mori NNP cord-001397-nrq4ncdf 75 12 et et FW cord-001397-nrq4ncdf 75 13 al al NNP cord-001397-nrq4ncdf 75 14 . . NNP cord-001397-nrq4ncdf 75 15 , , , cord-001397-nrq4ncdf 75 16 2005 2005 CD cord-001397-nrq4ncdf 75 17 ) ) -RRB- cord-001397-nrq4ncdf 76 1 The the DT cord-001397-nrq4ncdf 76 2 C c NN cord-001397-nrq4ncdf 76 3 - - HYPH cord-001397-nrq4ncdf 76 4 encoding encode VBG cord-001397-nrq4ncdf 76 5 nucleotide nucleotide JJ cord-001397-nrq4ncdf 76 6 sequence sequence NN cord-001397-nrq4ncdf 76 7 of of IN cord-001397-nrq4ncdf 76 8 TBEV TBEV NNP cord-001397-nrq4ncdf 76 9 contains contain VBZ cord-001397-nrq4ncdf 76 10 conserved conserve VBN cord-001397-nrq4ncdf 76 11 RNA RNA NNP cord-001397-nrq4ncdf 76 12 structures structure NNS cord-001397-nrq4ncdf 76 13 that that WDT cord-001397-nrq4ncdf 76 14 function function VBP cord-001397-nrq4ncdf 76 15 as as IN cord-001397-nrq4ncdf 76 16 replication replication NN cord-001397-nrq4ncdf 76 17 enhancer enhancer NN cord-001397-nrq4ncdf 76 18 elements element NNS cord-001397-nrq4ncdf 76 19 ( ( -LRB- cord-001397-nrq4ncdf 76 20 Tuplin Tuplin NNP cord-001397-nrq4ncdf 76 21 et et FW cord-001397-nrq4ncdf 76 22 al al NNP cord-001397-nrq4ncdf 76 23 . . NNP cord-001397-nrq4ncdf 76 24 , , , cord-001397-nrq4ncdf 76 25 2011 2011 CD cord-001397-nrq4ncdf 76 26 ) ) -RRB- cord-001397-nrq4ncdf 77 1 † † UH cord-001397-nrq4ncdf 77 2 Precursor precursor NN cord-001397-nrq4ncdf 77 3 membrane membrane NN cord-001397-nrq4ncdf 77 4 ( ( -LRB- cord-001397-nrq4ncdf 77 5 prM prm JJ cord-001397-nrq4ncdf 77 6 ) ) -RRB- cord-001397-nrq4ncdf 77 7 469 469 CD cord-001397-nrq4ncdf 77 8 - - SYM cord-001397-nrq4ncdf 77 9 972 972 CD cord-001397-nrq4ncdf 77 10 , , , cord-001397-nrq4ncdf 77 11 26 26 CD cord-001397-nrq4ncdf 77 12 kDa kDa NNS cord-001397-nrq4ncdf 77 13 , , , cord-001397-nrq4ncdf 77 14 165 165 CD cord-001397-nrq4ncdf 77 15 aa aa NN cord-001397-nrq4ncdf 77 16 ER ER NNP cord-001397-nrq4ncdf 77 17 lumen lumen NN cord-001397-nrq4ncdf 77 18 During during IN cord-001397-nrq4ncdf 77 19 virion virion NN cord-001397-nrq4ncdf 77 20 assembly assembly NN cord-001397-nrq4ncdf 77 21 , , , cord-001397-nrq4ncdf 77 22 the the DT cord-001397-nrq4ncdf 77 23 prM prm JJ cord-001397-nrq4ncdf 77 24 forms form NNS cord-001397-nrq4ncdf 77 25 a a DT cord-001397-nrq4ncdf 77 26 heterodimer heterodimer NN cord-001397-nrq4ncdf 77 27 with with IN cord-001397-nrq4ncdf 77 28 the the DT cord-001397-nrq4ncdf 77 29 E e NN cord-001397-nrq4ncdf 77 30 protein protein NN cord-001397-nrq4ncdf 77 31 and and CC cord-001397-nrq4ncdf 77 32 acts act VBZ cord-001397-nrq4ncdf 77 33 as as IN cord-001397-nrq4ncdf 77 34 a a DT cord-001397-nrq4ncdf 77 35 chaperone chaperone NN cord-001397-nrq4ncdf 77 36 for for IN cord-001397-nrq4ncdf 77 37 correct correct JJ cord-001397-nrq4ncdf 77 38 E e NN cord-001397-nrq4ncdf 77 39 protein protein NN cord-001397-nrq4ncdf 77 40 folding folding NN cord-001397-nrq4ncdf 77 41 ( ( -LRB- cord-001397-nrq4ncdf 77 42 Kuhn Kuhn NNP cord-001397-nrq4ncdf 77 43 et et NNP cord-001397-nrq4ncdf 77 44 al al NNP cord-001397-nrq4ncdf 77 45 . . . cord-001397-nrq4ncdf 78 1 , , , cord-001397-nrq4ncdf 78 2 2002 2002 CD cord-001397-nrq4ncdf 78 3 ; ; : cord-001397-nrq4ncdf 78 4 Lorenz Lorenz NNP cord-001397-nrq4ncdf 78 5 et et NNP cord-001397-nrq4ncdf 78 6 al al NNP cord-001397-nrq4ncdf 78 7 . . . cord-001397-nrq4ncdf 79 1 , , , cord-001397-nrq4ncdf 79 2 2002 2002 CD cord-001397-nrq4ncdf 79 3 ; ; : cord-001397-nrq4ncdf 79 4 Zhang Zhang NNP cord-001397-nrq4ncdf 79 5 et et NNP cord-001397-nrq4ncdf 79 6 al al NNP cord-001397-nrq4ncdf 79 7 . . NNP cord-001397-nrq4ncdf 79 8 , , , cord-001397-nrq4ncdf 79 9 2003 2003 CD cord-001397-nrq4ncdf 79 10 ) ) -RRB- cord-001397-nrq4ncdf 79 11 . . . cord-001397-nrq4ncdf 80 1 In in IN cord-001397-nrq4ncdf 80 2 the the DT cord-001397-nrq4ncdf 80 3 final final JJ cord-001397-nrq4ncdf 80 4 step step NN cord-001397-nrq4ncdf 80 5 of of IN cord-001397-nrq4ncdf 80 6 virion virion NN cord-001397-nrq4ncdf 80 7 maturation maturation NN cord-001397-nrq4ncdf 80 8 in in IN cord-001397-nrq4ncdf 80 9 the the DT cord-001397-nrq4ncdf 80 10 trans trans NNP cord-001397-nrq4ncdf 80 11 - - NNP cord-001397-nrq4ncdf 80 12 Golgi Golgi NNP cord-001397-nrq4ncdf 80 13 network network NN cord-001397-nrq4ncdf 80 14 prior prior RB cord-001397-nrq4ncdf 80 15 , , , cord-001397-nrq4ncdf 80 16 to to IN cord-001397-nrq4ncdf 80 17 viral viral JJ cord-001397-nrq4ncdf 80 18 release release NN cord-001397-nrq4ncdf 80 19 , , , cord-001397-nrq4ncdf 80 20 the the DT cord-001397-nrq4ncdf 80 21 precursor precursor NN cord-001397-nrq4ncdf 80 22 is be VBZ cord-001397-nrq4ncdf 80 23 cleaved cleave VBN cord-001397-nrq4ncdf 80 24 by by IN cord-001397-nrq4ncdf 80 25 furin furin NN cord-001397-nrq4ncdf 80 26 and and CC cord-001397-nrq4ncdf 80 27 only only RB cord-001397-nrq4ncdf 80 28 the the DT cord-001397-nrq4ncdf 80 29 C C NNP cord-001397-nrq4ncdf 80 30 - - HYPH cord-001397-nrq4ncdf 80 31 terminal terminal NN cord-001397-nrq4ncdf 80 32 region region NN cord-001397-nrq4ncdf 80 33 ( ( -LRB- cord-001397-nrq4ncdf 80 34 M M NNP cord-001397-nrq4ncdf 80 35 ) ) -RRB- cord-001397-nrq4ncdf 80 36 is be VBZ cord-001397-nrq4ncdf 80 37 retained retain VBN cord-001397-nrq4ncdf 80 38 in in IN cord-001397-nrq4ncdf 80 39 the the DT cord-001397-nrq4ncdf 80 40 viral viral JJ cord-001397-nrq4ncdf 80 41 membrane membrane NN cord-001397-nrq4ncdf 80 42 ( ( -LRB- cord-001397-nrq4ncdf 80 43 Heinz Heinz NNP cord-001397-nrq4ncdf 80 44 et et NNP cord-001397-nrq4ncdf 80 45 al al NNP cord-001397-nrq4ncdf 80 46 . . NNP cord-001397-nrq4ncdf 80 47 , , , cord-001397-nrq4ncdf 80 48 1994 1994 CD cord-001397-nrq4ncdf 80 49 ; ; : cord-001397-nrq4ncdf 80 50 Elshuber Elshuber NNP cord-001397-nrq4ncdf 80 51 & & CC cord-001397-nrq4ncdf 80 52 Mandl Mandl NNP cord-001397-nrq4ncdf 80 53 , , , cord-001397-nrq4ncdf 80 54 2005 2005 CD cord-001397-nrq4ncdf 80 55 ; ; : cord-001397-nrq4ncdf 80 56 Lindenbach Lindenbach NNP cord-001397-nrq4ncdf 80 57 et et NNP cord-001397-nrq4ncdf 80 58 al al NNP cord-001397-nrq4ncdf 80 59 . . NNP cord-001397-nrq4ncdf 80 60 , , , cord-001397-nrq4ncdf 80 61 2007 2007 CD cord-001397-nrq4ncdf 80 62 ) ) -RRB- cord-001397-nrq4ncdf 80 63 . . . cord-001397-nrq4ncdf 81 1 prM prm JJ cord-001397-nrq4ncdf 81 2 protein protein NN cord-001397-nrq4ncdf 81 3 of of IN cord-001397-nrq4ncdf 81 4 JEV JEV NNP cord-001397-nrq4ncdf 81 5 also also RB cord-001397-nrq4ncdf 81 6 limits limit VBZ cord-001397-nrq4ncdf 82 1 viral viral JJ cord-001397-nrq4ncdf 82 2 neurovirulence neurovirulence NNP cord-001397-nrq4ncdf 82 3 ( ( -LRB- cord-001397-nrq4ncdf 82 4 Kim Kim NNP cord-001397-nrq4ncdf 82 5 et et NNP cord-001397-nrq4ncdf 82 6 al al NNP cord-001397-nrq4ncdf 82 7 . . NNP cord-001397-nrq4ncdf 82 8 , , , cord-001397-nrq4ncdf 82 9 2008 2008 CD cord-001397-nrq4ncdf 82 10 ) ) -RRB- cord-001397-nrq4ncdf 82 11 † † NN cord-001397-nrq4ncdf 83 1 ( ( -LRB- cord-001397-nrq4ncdf 83 2 Bressanelli Bressanelli NNP cord-001397-nrq4ncdf 83 3 et et NNP cord-001397-nrq4ncdf 83 4 al al NNP cord-001397-nrq4ncdf 83 5 . . NNP cord-001397-nrq4ncdf 83 6 , , , cord-001397-nrq4ncdf 83 7 2004 2004 CD cord-001397-nrq4ncdf 83 8 ) ) -RRB- cord-001397-nrq4ncdf 83 9 . . . cord-001397-nrq4ncdf 84 1 The the DT cord-001397-nrq4ncdf 84 2 glycoprotein glycoprotein NN cord-001397-nrq4ncdf 84 3 forms form VBZ cord-001397-nrq4ncdf 84 4 ' ' POS cord-001397-nrq4ncdf 84 5 head head NN cord-001397-nrq4ncdf 84 6 to to IN cord-001397-nrq4ncdf 84 7 tail tail NN cord-001397-nrq4ncdf 84 8 ' ' `` cord-001397-nrq4ncdf 84 9 homodimers homodimer NNS cord-001397-nrq4ncdf 84 10 that that WDT cord-001397-nrq4ncdf 84 11 completely completely RB cord-001397-nrq4ncdf 84 12 cover cover VBP cord-001397-nrq4ncdf 84 13 the the DT cord-001397-nrq4ncdf 84 14 surface surface NN cord-001397-nrq4ncdf 84 15 of of IN cord-001397-nrq4ncdf 84 16 the the DT cord-001397-nrq4ncdf 84 17 mature mature JJ cord-001397-nrq4ncdf 84 18 icosahedral icosahedral JJ cord-001397-nrq4ncdf 84 19 virions virion NNS cord-001397-nrq4ncdf 84 20 . . . cord-001397-nrq4ncdf 85 1 It -PRON- PRP cord-001397-nrq4ncdf 85 2 is be VBZ cord-001397-nrq4ncdf 85 3 also also RB cord-001397-nrq4ncdf 85 4 responsible responsible JJ cord-001397-nrq4ncdf 85 5 for for IN cord-001397-nrq4ncdf 85 6 receptor receptor NN cord-001397-nrq4ncdf 85 7 binding binding NN cord-001397-nrq4ncdf 85 8 , , , cord-001397-nrq4ncdf 85 9 which which WDT cord-001397-nrq4ncdf 85 10 leads lead VBZ cord-001397-nrq4ncdf 85 11 to to IN cord-001397-nrq4ncdf 85 12 virus virus NN cord-001397-nrq4ncdf 85 13 internalization internalization NN cord-001397-nrq4ncdf 85 14 by by IN cord-001397-nrq4ncdf 85 15 clathrin clathrin NN cord-001397-nrq4ncdf 85 16 - - HYPH cord-001397-nrq4ncdf 85 17 mediated mediate VBN cord-001397-nrq4ncdf 85 18 endocytosis endocytosis NN cord-001397-nrq4ncdf 85 19 ( ( -LRB- cord-001397-nrq4ncdf 85 20 Lindenbach Lindenbach NNP cord-001397-nrq4ncdf 85 21 et et NNP cord-001397-nrq4ncdf 85 22 al al NNP cord-001397-nrq4ncdf 85 23 . . NNP cord-001397-nrq4ncdf 85 24 , , , cord-001397-nrq4ncdf 85 25 2007 2007 CD cord-001397-nrq4ncdf 85 26 ) ) -RRB- cord-001397-nrq4ncdf 85 27 . . . cord-001397-nrq4ncdf 86 1 The the DT cord-001397-nrq4ncdf 86 2 E e NN cord-001397-nrq4ncdf 86 3 protein protein NN cord-001397-nrq4ncdf 86 4 contains contain VBZ cord-001397-nrq4ncdf 86 5 three three CD cord-001397-nrq4ncdf 86 6 b b NN cord-001397-nrq4ncdf 86 7 - - HYPH cord-001397-nrq4ncdf 86 8 sheets sheet NNS cord-001397-nrq4ncdf 86 9 domains domain NNS cord-001397-nrq4ncdf 86 10 ( ( -LRB- cord-001397-nrq4ncdf 86 11 DI DI NNP cord-001397-nrq4ncdf 86 12 - - HYPH cord-001397-nrq4ncdf 86 13 DIII DIII NNP cord-001397-nrq4ncdf 86 14 ) ) -RRB- cord-001397-nrq4ncdf 86 15 : : : cord-001397-nrq4ncdf 86 16 DII DII NNP cord-001397-nrq4ncdf 86 17 includes include VBZ cord-001397-nrq4ncdf 86 18 the the DT cord-001397-nrq4ncdf 86 19 membrane membrane NN cord-001397-nrq4ncdf 86 20 fusion fusion NN cord-001397-nrq4ncdf 86 21 peptide peptide NN cord-001397-nrq4ncdf 86 22 ( ( -LRB- cord-001397-nrq4ncdf 86 23 Beasley Beasley NNP cord-001397-nrq4ncdf 86 24 & & CC cord-001397-nrq4ncdf 86 25 Barrett Barrett NNP cord-001397-nrq4ncdf 86 26 , , , cord-001397-nrq4ncdf 86 27 2002 2002 CD cord-001397-nrq4ncdf 86 28 ; ; : cord-001397-nrq4ncdf 86 29 Bressanelli Bressanelli NNP cord-001397-nrq4ncdf 86 30 et et NNP cord-001397-nrq4ncdf 86 31 al al NNP cord-001397-nrq4ncdf 86 32 . . NNP cord-001397-nrq4ncdf 86 33 , , , cord-001397-nrq4ncdf 86 34 2004 2004 CD cord-001397-nrq4ncdf 86 35 ; ; : cord-001397-nrq4ncdf 86 36 Sukupolvi Sukupolvi NNP cord-001397-nrq4ncdf 86 37 - - HYPH cord-001397-nrq4ncdf 86 38 Petty Petty NNP cord-001397-nrq4ncdf 86 39 et et NNP cord-001397-nrq4ncdf 86 40 al al NNP cord-001397-nrq4ncdf 86 41 . . NNP cord-001397-nrq4ncdf 86 42 , , , cord-001397-nrq4ncdf 86 43 2007 2007 CD cord-001397-nrq4ncdf 86 44 ) ) -RRB- cord-001397-nrq4ncdf 86 45 ; ; : cord-001397-nrq4ncdf 86 46 DIII DIII NNP cord-001397-nrq4ncdf 86 47 is be VBZ cord-001397-nrq4ncdf 86 48 associated associate VBN cord-001397-nrq4ncdf 86 49 with with IN cord-001397-nrq4ncdf 86 50 receptor receptor NN cord-001397-nrq4ncdf 86 51 binding binding NN cord-001397-nrq4ncdf 86 52 and and CC cord-001397-nrq4ncdf 86 53 is be VBZ cord-001397-nrq4ncdf 86 54 also also RB cord-001397-nrq4ncdf 86 55 a a DT cord-001397-nrq4ncdf 86 56 target target NN cord-001397-nrq4ncdf 86 57 for for IN cord-001397-nrq4ncdf 86 58 several several JJ cord-001397-nrq4ncdf 86 59 neutralizing neutralize VBG cord-001397-nrq4ncdf 86 60 monoclonal monoclonal JJ cord-001397-nrq4ncdf 86 61 antibodies antibody NNS cord-001397-nrq4ncdf 86 62 . . . cord-001397-nrq4ncdf 87 1 Crystal crystal NN cord-001397-nrq4ncdf 87 2 structures structure NNS cord-001397-nrq4ncdf 87 3 of of IN cord-001397-nrq4ncdf 87 4 the the DT cord-001397-nrq4ncdf 87 5 E e NN cord-001397-nrq4ncdf 87 6 protein protein NN cord-001397-nrq4ncdf 87 7 from from IN cord-001397-nrq4ncdf 87 8 several several JJ cord-001397-nrq4ncdf 87 9 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 87 10 all all DT cord-001397-nrq4ncdf 87 11 show show VBP cord-001397-nrq4ncdf 87 12 similar similar JJ cord-001397-nrq4ncdf 87 13 secondary secondary JJ cord-001397-nrq4ncdf 87 14 structure structure NN cord-001397-nrq4ncdf 87 15 and and CC cord-001397-nrq4ncdf 87 16 domain domain NN cord-001397-nrq4ncdf 87 17 organization organization NN cord-001397-nrq4ncdf 87 18 ( ( -LRB- cord-001397-nrq4ncdf 87 19 Modis Modis NNP cord-001397-nrq4ncdf 87 20 et et NNP cord-001397-nrq4ncdf 87 21 al al NNP cord-001397-nrq4ncdf 87 22 . . . cord-001397-nrq4ncdf 88 1 , , , cord-001397-nrq4ncdf 88 2 2003 2003 CD cord-001397-nrq4ncdf 88 3 ( ( -LRB- cord-001397-nrq4ncdf 88 4 Modis Modis NNP cord-001397-nrq4ncdf 88 5 et et NNP cord-001397-nrq4ncdf 88 6 al al NNP cord-001397-nrq4ncdf 88 7 . . . cord-001397-nrq4ncdf 89 1 , , , cord-001397-nrq4ncdf 89 2 , , , cord-001397-nrq4ncdf 89 3 2005 2005 CD cord-001397-nrq4ncdf 89 4 Zhang Zhang NNP cord-001397-nrq4ncdf 89 5 et et NNP cord-001397-nrq4ncdf 89 6 al al NNP cord-001397-nrq4ncdf 89 7 . . NNP cord-001397-nrq4ncdf 89 8 , , , cord-001397-nrq4ncdf 89 9 2004 2004 CD cord-001397-nrq4ncdf 89 10 ; ; : cord-001397-nrq4ncdf 90 1 Kanai Kanai NNP cord-001397-nrq4ncdf 90 2 et et NNP cord-001397-nrq4ncdf 90 3 al al NNP cord-001397-nrq4ncdf 90 4 . . NNP cord-001397-nrq4ncdf 90 5 , , , cord-001397-nrq4ncdf 90 6 2006 2006 CD cord-001397-nrq4ncdf 91 1 ; ; : cord-001397-nrq4ncdf 91 2 Nybakken Nybakken NNP cord-001397-nrq4ncdf 91 3 et et FW cord-001397-nrq4ncdf 91 4 al al NNP cord-001397-nrq4ncdf 91 5 . . NNP cord-001397-nrq4ncdf 91 6 , , , cord-001397-nrq4ncdf 91 7 2006 2006 CD cord-001397-nrq4ncdf 91 8 ) ) -RRB- cord-001397-nrq4ncdf 91 9 . . . cord-001397-nrq4ncdf 92 1 The the DT cord-001397-nrq4ncdf 92 2 E e NN cord-001397-nrq4ncdf 92 3 protein protein NN cord-001397-nrq4ncdf 92 4 is be VBZ cord-001397-nrq4ncdf 92 5 important important JJ cord-001397-nrq4ncdf 92 6 in in IN cord-001397-nrq4ncdf 92 7 determining determine VBG cord-001397-nrq4ncdf 92 8 neuroinvasiveness neuroinvasiveness NN cord-001397-nrq4ncdf 92 9 and and CC cord-001397-nrq4ncdf 92 10 neurovirulence neurovirulence NN cord-001397-nrq4ncdf 92 11 for for IN cord-001397-nrq4ncdf 92 12 several several JJ cord-001397-nrq4ncdf 92 13 MBFVs mbfv NNS cord-001397-nrq4ncdf 92 14 ( ( -LRB- cord-001397-nrq4ncdf 92 15 Cecilia Cecilia NNP cord-001397-nrq4ncdf 92 16 & & CC cord-001397-nrq4ncdf 92 17 Gould Gould NNP cord-001397-nrq4ncdf 92 18 , , , cord-001397-nrq4ncdf 92 19 1991 1991 CD cord-001397-nrq4ncdf 92 20 ; ; : cord-001397-nrq4ncdf 93 1 Hiramatsu Hiramatsu NNP cord-001397-nrq4ncdf 93 2 et et NNP cord-001397-nrq4ncdf 93 3 al al NNP cord-001397-nrq4ncdf 93 4 . . . cord-001397-nrq4ncdf 94 1 , , , cord-001397-nrq4ncdf 94 2 1996 1996 CD cord-001397-nrq4ncdf 94 3 ; ; : cord-001397-nrq4ncdf 94 4 Ni Ni NNP cord-001397-nrq4ncdf 94 5 & & CC cord-001397-nrq4ncdf 94 6 Barrett Barrett NNP cord-001397-nrq4ncdf 94 7 , , , cord-001397-nrq4ncdf 94 8 1996 1996 CD cord-001397-nrq4ncdf 94 9 ; ; : cord-001397-nrq4ncdf 94 10 Sanchez Sanchez NNP cord-001397-nrq4ncdf 94 11 & & CC cord-001397-nrq4ncdf 94 12 Ruiz Ruiz NNP cord-001397-nrq4ncdf 94 13 , , , cord-001397-nrq4ncdf 94 14 1996 1996 CD cord-001397-nrq4ncdf 94 15 ; ; : cord-001397-nrq4ncdf 94 16 Chambers Chambers NNP cord-001397-nrq4ncdf 94 17 et et NNP cord-001397-nrq4ncdf 94 18 al al NNP cord-001397-nrq4ncdf 94 19 . . NNP cord-001397-nrq4ncdf 94 20 , , , cord-001397-nrq4ncdf 94 21 1998 1998 CD cord-001397-nrq4ncdf 94 22 ; ; : cord-001397-nrq4ncdf 94 23 Beasley Beasley NNP cord-001397-nrq4ncdf 94 24 et et NNP cord-001397-nrq4ncdf 94 25 al al NNP cord-001397-nrq4ncdf 94 26 . . NNP cord-001397-nrq4ncdf 94 27 , , , cord-001397-nrq4ncdf 94 28 2004 2004 CD cord-001397-nrq4ncdf 94 29 ; ; : cord-001397-nrq4ncdf 94 30 Lee Lee NNP cord-001397-nrq4ncdf 94 31 et et NNP cord-001397-nrq4ncdf 94 32 al al NNP cord-001397-nrq4ncdf 94 33 . . NNP cord-001397-nrq4ncdf 94 34 , , , cord-001397-nrq4ncdf 94 35 2004 2004 CD cord-001397-nrq4ncdf 95 1 Lee Lee NNP cord-001397-nrq4ncdf 95 2 et et NNP cord-001397-nrq4ncdf 95 3 al al NNP cord-001397-nrq4ncdf 95 4 . . . cord-001397-nrq4ncdf 96 1 , , , cord-001397-nrq4ncdf 96 2 , , , cord-001397-nrq4ncdf 96 3 2006 2006 CD cord-001397-nrq4ncdf 96 4 Bordignon Bordignon NNP cord-001397-nrq4ncdf 96 5 et et FW cord-001397-nrq4ncdf 96 6 al al NNP cord-001397-nrq4ncdf 96 7 . . NNP cord-001397-nrq4ncdf 96 8 , , , cord-001397-nrq4ncdf 96 9 2007 2007 CD cord-001397-nrq4ncdf 96 10 ) ) -RRB- cord-001397-nrq4ncdf 96 11 . . . cord-001397-nrq4ncdf 97 1 For for IN cord-001397-nrq4ncdf 97 2 WNV WNV NNP cord-001397-nrq4ncdf 97 3 , , , cord-001397-nrq4ncdf 97 4 JEV JEV NNP cord-001397-nrq4ncdf 97 5 , , , cord-001397-nrq4ncdf 97 6 and and CC cord-001397-nrq4ncdf 97 7 DENV DENV NNP cord-001397-nrq4ncdf 97 8 , , , cord-001397-nrq4ncdf 97 9 mutations mutation NNS cord-001397-nrq4ncdf 97 10 in in IN cord-001397-nrq4ncdf 97 11 the the DT cord-001397-nrq4ncdf 97 12 E e NN cord-001397-nrq4ncdf 97 13 protein protein NN cord-001397-nrq4ncdf 97 14 ( ( -LRB- cord-001397-nrq4ncdf 97 15 located locate VBN cord-001397-nrq4ncdf 97 16 in in IN cord-001397-nrq4ncdf 97 17 the the DT cord-001397-nrq4ncdf 97 18 lateral lateral JJ cord-001397-nrq4ncdf 97 19 surface surface NN cord-001397-nrq4ncdf 97 20 of of IN cord-001397-nrq4ncdf 97 21 DIII DIII NNP cord-001397-nrq4ncdf 97 22 and and CC cord-001397-nrq4ncdf 97 23 the the DT cord-001397-nrq4ncdf 97 24 base base NN cord-001397-nrq4ncdf 97 25 of of IN cord-001397-nrq4ncdf 97 26 DII DII NNP cord-001397-nrq4ncdf 97 27 ) ) -RRB- cord-001397-nrq4ncdf 97 28 affect affect VBP cord-001397-nrq4ncdf 97 29 fusion fusion NN cord-001397-nrq4ncdf 97 30 and and CC cord-001397-nrq4ncdf 97 31 receptor receptor NN cord-001397-nrq4ncdf 97 32 binding bind VBG cord-001397-nrq4ncdf 97 33 with with IN cord-001397-nrq4ncdf 97 34 target target NN cord-001397-nrq4ncdf 97 35 cells cell NNS cord-001397-nrq4ncdf 97 36 ( ( -LRB- cord-001397-nrq4ncdf 97 37 Lee Lee NNP cord-001397-nrq4ncdf 97 38 et et NNP cord-001397-nrq4ncdf 97 39 al al NNP cord-001397-nrq4ncdf 97 40 . . NNP cord-001397-nrq4ncdf 97 41 , , , cord-001397-nrq4ncdf 97 42 2004 2004 CD cord-001397-nrq4ncdf 97 43 ) ) -RRB- cord-001397-nrq4ncdf 98 1 The the DT cord-001397-nrq4ncdf 98 2 E e NN cord-001397-nrq4ncdf 98 3 protein protein NN cord-001397-nrq4ncdf 98 4 was be VBD cord-001397-nrq4ncdf 98 5 first first RB cord-001397-nrq4ncdf 98 6 described describe VBN cord-001397-nrq4ncdf 98 7 in in IN cord-001397-nrq4ncdf 98 8 1995 1995 CD cord-001397-nrq4ncdf 98 9 and and CC cord-001397-nrq4ncdf 98 10 later later RB cord-001397-nrq4ncdf 98 11 has have VBZ cord-001397-nrq4ncdf 98 12 been be VBN cord-001397-nrq4ncdf 98 13 extensively extensively RB cord-001397-nrq4ncdf 98 14 defined define VBN cord-001397-nrq4ncdf 98 15 and and CC cord-001397-nrq4ncdf 98 16 crystalized crystalize VBN cord-001397-nrq4ncdf 98 17 for for IN cord-001397-nrq4ncdf 98 18 many many JJ cord-001397-nrq4ncdf 98 19 other other JJ cord-001397-nrq4ncdf 98 20 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 98 21 ( ( -LRB- cord-001397-nrq4ncdf 98 22 Rey Rey NNP cord-001397-nrq4ncdf 98 23 et et NNP cord-001397-nrq4ncdf 98 24 al al NNP cord-001397-nrq4ncdf 98 25 . . NNP cord-001397-nrq4ncdf 98 26 , , , cord-001397-nrq4ncdf 98 27 1995 1995 CD cord-001397-nrq4ncdf 98 28 ) ) -RRB- cord-001397-nrq4ncdf 98 29 . . . cord-001397-nrq4ncdf 99 1 TBFV tbfv NN cord-001397-nrq4ncdf 99 2 E e NN cord-001397-nrq4ncdf 99 3 protein protein NN cord-001397-nrq4ncdf 99 4 is be VBZ cord-001397-nrq4ncdf 99 5 important important JJ cord-001397-nrq4ncdf 99 6 for for IN cord-001397-nrq4ncdf 99 7 determining determine VBG cord-001397-nrq4ncdf 99 8 neurovirulence neurovirulence NNP cord-001397-nrq4ncdf 99 9 and and CC cord-001397-nrq4ncdf 99 10 neuroinvasiveness neuroinvasiveness NN cord-001397-nrq4ncdf 99 11 ( ( -LRB- cord-001397-nrq4ncdf 99 12 Holzmann Holzmann NNP cord-001397-nrq4ncdf 99 13 et et NNP cord-001397-nrq4ncdf 99 14 al al NNP cord-001397-nrq4ncdf 99 15 . . . cord-001397-nrq4ncdf 100 1 , , , cord-001397-nrq4ncdf 100 2 1990 1990 CD cord-001397-nrq4ncdf 100 3 ; ; : cord-001397-nrq4ncdf 100 4 McMinn McMinn NNP cord-001397-nrq4ncdf 100 5 , , , cord-001397-nrq4ncdf 100 6 1997 1997 CD cord-001397-nrq4ncdf 100 7 ; ; : cord-001397-nrq4ncdf 100 8 Beasley Beasley NNP cord-001397-nrq4ncdf 100 9 et et NNP cord-001397-nrq4ncdf 100 10 al al NNP cord-001397-nrq4ncdf 100 11 . . NNP cord-001397-nrq4ncdf 100 12 , , , cord-001397-nrq4ncdf 100 13 2005 2005 CD cord-001397-nrq4ncdf 100 14 ; ; : cord-001397-nrq4ncdf 100 15 Mandl Mandl NNP cord-001397-nrq4ncdf 100 16 , , , cord-001397-nrq4ncdf 100 17 2005 2005 CD cord-001397-nrq4ncdf 100 18 ; ; : cord-001397-nrq4ncdf 100 19 Engel Engel NNP cord-001397-nrq4ncdf 100 20 et et NNP cord-001397-nrq4ncdf 100 21 al al NNP cord-001397-nrq4ncdf 100 22 . . NNP cord-001397-nrq4ncdf 100 23 , , , cord-001397-nrq4ncdf 100 24 2010 2010 CD cord-001397-nrq4ncdf 100 25 ) ) -RRB- cord-001397-nrq4ncdf 101 1 Nonstructural nonstructural JJ cord-001397-nrq4ncdf 101 2 Proteins protein NNS cord-001397-nrq4ncdf 101 3 NS1 ns1 CD cord-001397-nrq4ncdf 101 4 2461 2461 CD cord-001397-nrq4ncdf 101 5 - - HYPH cord-001397-nrq4ncdf 101 6 3516/46 3516/46 CD cord-001397-nrq4ncdf 101 7 - - HYPH cord-001397-nrq4ncdf 101 8 55 55 CD cord-001397-nrq4ncdf 102 1 kDa/325 kDa/325 NNP cord-001397-nrq4ncdf 102 2 aa aa NNP cord-001397-nrq4ncdf 103 1 ER ER NNP cord-001397-nrq4ncdf 103 2 lumen lumen NNP cord-001397-nrq4ncdf 103 3 / / SYM cord-001397-nrq4ncdf 103 4 cytosol/ cytosol/ CD cord-001397-nrq4ncdf 103 5 secreted secrete VBD cord-001397-nrq4ncdf 103 6 Low low JJ cord-001397-nrq4ncdf 103 7 - - HYPH cord-001397-nrq4ncdf 103 8 resolution resolution NN cord-001397-nrq4ncdf 103 9 structural structural JJ cord-001397-nrq4ncdf 103 10 studies study NNS cord-001397-nrq4ncdf 103 11 found find VBD cord-001397-nrq4ncdf 103 12 the the DT cord-001397-nrq4ncdf 103 13 NS1 ns1 CD cord-001397-nrq4ncdf 103 14 structure structure NN cord-001397-nrq4ncdf 103 15 to to TO cord-001397-nrq4ncdf 103 16 be be VB cord-001397-nrq4ncdf 103 17 an an DT cord-001397-nrq4ncdf 103 18 open open JJ cord-001397-nrq4ncdf 103 19 barrel barrel NN cord-001397-nrq4ncdf 103 20 configuration configuration NN cord-001397-nrq4ncdf 103 21 with with IN cord-001397-nrq4ncdf 103 22 D3 D3 NNP cord-001397-nrq4ncdf 103 23 symmetry symmetry NN cord-001397-nrq4ncdf 103 24 measuring measure VBG cord-001397-nrq4ncdf 103 25 10 10 CD cord-001397-nrq4ncdf 103 26 nm nm NN cord-001397-nrq4ncdf 103 27 by by IN cord-001397-nrq4ncdf 103 28 7.5 7.5 CD cord-001397-nrq4ncdf 103 29 nm nm NN cord-001397-nrq4ncdf 103 30 and and CC cord-001397-nrq4ncdf 103 31 with with IN cord-001397-nrq4ncdf 103 32 a a DT cord-001397-nrq4ncdf 103 33 central central JJ cord-001397-nrq4ncdf 103 34 cavity cavity NN cord-001397-nrq4ncdf 103 35 approximately approximately RB cord-001397-nrq4ncdf 103 36 4.5 4.5 CD cord-001397-nrq4ncdf 103 37 nm nm CD cord-001397-nrq4ncdf 103 38 in in IN cord-001397-nrq4ncdf 103 39 diameter diameter NN cord-001397-nrq4ncdf 104 1 ( ( -LRB- cord-001397-nrq4ncdf 104 2 Gutsche Gutsche NNP cord-001397-nrq4ncdf 104 3 et et NNP cord-001397-nrq4ncdf 104 4 al al NNP cord-001397-nrq4ncdf 104 5 . . NNP cord-001397-nrq4ncdf 104 6 , , , cord-001397-nrq4ncdf 104 7 2011 2011 CD cord-001397-nrq4ncdf 104 8 ; ; : cord-001397-nrq4ncdf 104 9 Edeling Edeling NNP cord-001397-nrq4ncdf 104 10 et et FW cord-001397-nrq4ncdf 104 11 al al NNP cord-001397-nrq4ncdf 104 12 . . NNP cord-001397-nrq4ncdf 104 13 , , , cord-001397-nrq4ncdf 104 14 2014 2014 CD cord-001397-nrq4ncdf 104 15 ) ) -RRB- cord-001397-nrq4ncdf 104 16 . . . cord-001397-nrq4ncdf 105 1 All all DT cord-001397-nrq4ncdf 105 2 flavivirus flavivirus NNP cord-001397-nrq4ncdf 105 3 NS1 NS1 NNP cord-001397-nrq4ncdf 105 4 genes gene NNS cord-001397-nrq4ncdf 105 5 share share VBP cord-001397-nrq4ncdf 105 6 a a DT cord-001397-nrq4ncdf 105 7 conserved conserved JJ cord-001397-nrq4ncdf 105 8 degree degree NN cord-001397-nrq4ncdf 105 9 of of IN cord-001397-nrq4ncdf 105 10 homology homology NN cord-001397-nrq4ncdf 105 11 . . . cord-001397-nrq4ncdf 106 1 NS1 NS1 NNS cord-001397-nrq4ncdf 106 2 is be VBZ cord-001397-nrq4ncdf 106 3 found find VBN cord-001397-nrq4ncdf 106 4 at at IN cord-001397-nrq4ncdf 106 5 different different JJ cord-001397-nrq4ncdf 106 6 cellular cellular JJ cord-001397-nrq4ncdf 106 7 locations location NNS cord-001397-nrq4ncdf 106 8 such such JJ cord-001397-nrq4ncdf 106 9 as as IN cord-001397-nrq4ncdf 106 10 vesicular vesicular JJ cord-001397-nrq4ncdf 106 11 compartments compartment NNS cord-001397-nrq4ncdf 106 12 associated associate VBN cord-001397-nrq4ncdf 106 13 with with IN cord-001397-nrq4ncdf 106 14 the the DT cord-001397-nrq4ncdf 106 15 cell cell NN cord-001397-nrq4ncdf 106 16 membrane membrane NN cord-001397-nrq4ncdf 106 17 or or CC cord-001397-nrq4ncdf 106 18 on on IN cord-001397-nrq4ncdf 106 19 the the DT cord-001397-nrq4ncdf 106 20 cell cell NN cord-001397-nrq4ncdf 106 21 surface surface NN cord-001397-nrq4ncdf 106 22 and and CC cord-001397-nrq4ncdf 106 23 is be VBZ cord-001397-nrq4ncdf 106 24 also also RB cord-001397-nrq4ncdf 106 25 secreted secrete VBN cord-001397-nrq4ncdf 106 26 as as IN cord-001397-nrq4ncdf 106 27 an an DT cord-001397-nrq4ncdf 106 28 extracellular extracellular JJ cord-001397-nrq4ncdf 106 29 † † NN cord-001397-nrq4ncdf 106 30 Westaway Westaway NNP cord-001397-nrq4ncdf 106 31 et et NNP cord-001397-nrq4ncdf 106 32 al al NNP cord-001397-nrq4ncdf 106 33 . . NNP cord-001397-nrq4ncdf 106 34 , , , cord-001397-nrq4ncdf 106 35 1997 1997 CD cord-001397-nrq4ncdf 106 36 ; ; : cord-001397-nrq4ncdf 106 37 Lindenbach Lindenbach NNP cord-001397-nrq4ncdf 106 38 et et NNP cord-001397-nrq4ncdf 106 39 al al NNP cord-001397-nrq4ncdf 106 40 . . NNP cord-001397-nrq4ncdf 106 41 , , , cord-001397-nrq4ncdf 106 42 2007 2007 CD cord-001397-nrq4ncdf 106 43 ) ) -RRB- cord-001397-nrq4ncdf 106 44 . . . cord-001397-nrq4ncdf 107 1 Each each DT cord-001397-nrq4ncdf 107 2 subunit subunit NN cord-001397-nrq4ncdf 107 3 forms form VBZ cord-001397-nrq4ncdf 107 4 a a DT cord-001397-nrq4ncdf 107 5 homodimer homodimer NN cord-001397-nrq4ncdf 107 6 located locate VBN cord-001397-nrq4ncdf 107 7 in in IN cord-001397-nrq4ncdf 107 8 the the DT cord-001397-nrq4ncdf 107 9 ER ER NNP cord-001397-nrq4ncdf 107 10 lumen lumen NN cord-001397-nrq4ncdf 107 11 , , , cord-001397-nrq4ncdf 107 12 and and CC cord-001397-nrq4ncdf 107 13 it -PRON- PRP cord-001397-nrq4ncdf 107 14 has have VBZ cord-001397-nrq4ncdf 107 15 been be VBN cord-001397-nrq4ncdf 107 16 shown show VBN cord-001397-nrq4ncdf 107 17 to to IN cord-001397-nrq4ncdf 107 18 colocalize colocalize NN cord-001397-nrq4ncdf 107 19 with with IN cord-001397-nrq4ncdf 107 20 viral viral JJ cord-001397-nrq4ncdf 107 21 dsRNA dsrna NN cord-001397-nrq4ncdf 107 22 . . . cord-001397-nrq4ncdf 108 1 Secreted secrete VBN cord-001397-nrq4ncdf 108 2 and and CC cord-001397-nrq4ncdf 108 3 cell cell NN cord-001397-nrq4ncdf 108 4 surface surface NN cord-001397-nrq4ncdf 108 5 associated associate VBN cord-001397-nrq4ncdf 108 6 NS1 NS1 NNS cord-001397-nrq4ncdf 108 7 is be VBZ cord-001397-nrq4ncdf 108 8 immunogenic immunogenic JJ cord-001397-nrq4ncdf 108 9 and and CC cord-001397-nrq4ncdf 108 10 induces induce VBZ cord-001397-nrq4ncdf 108 11 an an DT cord-001397-nrq4ncdf 108 12 antibody antibody NN cord-001397-nrq4ncdf 108 13 response response NN cord-001397-nrq4ncdf 108 14 that that WDT cord-001397-nrq4ncdf 108 15 can can MD cord-001397-nrq4ncdf 108 16 serve serve VB cord-001397-nrq4ncdf 108 17 as as IN cord-001397-nrq4ncdf 108 18 an an DT cord-001397-nrq4ncdf 108 19 important important JJ cord-001397-nrq4ncdf 108 20 diagnosis diagnosis NN cord-001397-nrq4ncdf 108 21 marker marker NN cord-001397-nrq4ncdf 108 22 ( ( -LRB- cord-001397-nrq4ncdf 108 23 Falgout falgout NN cord-001397-nrq4ncdf 108 24 et et NNP cord-001397-nrq4ncdf 108 25 al al NNP cord-001397-nrq4ncdf 108 26 . . NNP cord-001397-nrq4ncdf 108 27 , , , cord-001397-nrq4ncdf 108 28 1990 1990 CD cord-001397-nrq4ncdf 108 29 ; ; : cord-001397-nrq4ncdf 108 30 Avirutnan Avirutnan NNP cord-001397-nrq4ncdf 108 31 et et NNP cord-001397-nrq4ncdf 108 32 al al NNP cord-001397-nrq4ncdf 108 33 . . . cord-001397-nrq4ncdf 109 1 , , , cord-001397-nrq4ncdf 109 2 2006 2006 CD cord-001397-nrq4ncdf 109 3 ; ; : cord-001397-nrq4ncdf 109 4 Sun Sun NNP cord-001397-nrq4ncdf 109 5 et et NNP cord-001397-nrq4ncdf 109 6 al al NNP cord-001397-nrq4ncdf 109 7 . . NNP cord-001397-nrq4ncdf 109 8 , , , cord-001397-nrq4ncdf 109 9 2007 2007 CD cord-001397-nrq4ncdf 109 10 ) ) -RRB- cord-001397-nrq4ncdf 109 11 . . . cord-001397-nrq4ncdf 110 1 NS1 ns1 NN cord-001397-nrq4ncdf 110 2 is be VBZ cord-001397-nrq4ncdf 110 3 also also RB cord-001397-nrq4ncdf 110 4 implicated implicate VBN cord-001397-nrq4ncdf 110 5 in in IN cord-001397-nrq4ncdf 110 6 immune immune JJ cord-001397-nrq4ncdf 110 7 evasion evasion NN cord-001397-nrq4ncdf 110 8 functions function NNS cord-001397-nrq4ncdf 110 9 as as IN cord-001397-nrq4ncdf 110 10 it -PRON- PRP cord-001397-nrq4ncdf 110 11 activates activate VBZ cord-001397-nrq4ncdf 110 12 human human JJ cord-001397-nrq4ncdf 110 13 complement complement NN cord-001397-nrq4ncdf 110 14 and and CC cord-001397-nrq4ncdf 110 15 induces induce VBZ cord-001397-nrq4ncdf 110 16 host host NN cord-001397-nrq4ncdf 110 17 vascular vascular JJ cord-001397-nrq4ncdf 110 18 leakage leakage NN cord-001397-nrq4ncdf 110 19 by by IN cord-001397-nrq4ncdf 110 20 specific specific JJ cord-001397-nrq4ncdf 110 21 inhibition inhibition NN cord-001397-nrq4ncdf 110 22 of of IN cord-001397-nrq4ncdf 110 23 the the DT cord-001397-nrq4ncdf 110 24 classical classical JJ cord-001397-nrq4ncdf 110 25 and and CC cord-001397-nrq4ncdf 110 26 lectin lectin NN cord-001397-nrq4ncdf 110 27 pathways pathway NNS cord-001397-nrq4ncdf 110 28 of of IN cord-001397-nrq4ncdf 110 29 complement complement JJ cord-001397-nrq4ncdf 110 30 activation activation NN cord-001397-nrq4ncdf 110 31 . . . cord-001397-nrq4ncdf 111 1 This this DT cord-001397-nrq4ncdf 111 2 occurs occur VBZ cord-001397-nrq4ncdf 111 3 through through IN cord-001397-nrq4ncdf 111 4 a a DT cord-001397-nrq4ncdf 111 5 direct direct JJ cord-001397-nrq4ncdf 111 6 interaction interaction NN cord-001397-nrq4ncdf 111 7 with with IN cord-001397-nrq4ncdf 111 8 complement complement JJ cord-001397-nrq4ncdf 111 9 components component NNS cord-001397-nrq4ncdf 111 10 C4 c4 NN cord-001397-nrq4ncdf 111 11 and and CC cord-001397-nrq4ncdf 111 12 C1s C1s . cord-001397-nrq4ncdf 112 1 ( ( -LRB- cord-001397-nrq4ncdf 112 2 Avirutnan Avirutnan NNP cord-001397-nrq4ncdf 112 3 et et NNP cord-001397-nrq4ncdf 112 4 al al NNP cord-001397-nrq4ncdf 112 5 . . NNP cord-001397-nrq4ncdf 112 6 , , , cord-001397-nrq4ncdf 112 7 2010 2010 CD cord-001397-nrq4ncdf 112 8 ) ) -RRB- cord-001397-nrq4ncdf 112 9 . . . cord-001397-nrq4ncdf 113 1 DENV DENV NNP cord-001397-nrq4ncdf 113 2 , , , cord-001397-nrq4ncdf 113 3 WNV WNV NNP cord-001397-nrq4ncdf 113 4 , , , cord-001397-nrq4ncdf 113 5 and and CC cord-001397-nrq4ncdf 113 6 YFV YFV NNP cord-001397-nrq4ncdf 113 7 NS1 NS1 NNS cord-001397-nrq4ncdf 113 8 are be VBP cord-001397-nrq4ncdf 113 9 shown show VBN cord-001397-nrq4ncdf 113 10 to to TO cord-001397-nrq4ncdf 113 11 limit limit VB cord-001397-nrq4ncdf 113 12 C4b c4b NN cord-001397-nrq4ncdf 113 13 deposition deposition NN cord-001397-nrq4ncdf 113 14 and and CC cord-001397-nrq4ncdf 113 15 C3 c3 NN cord-001397-nrq4ncdf 113 16 convertase convertase NN cord-001397-nrq4ncdf 113 17 activity activity NN cord-001397-nrq4ncdf 113 18 by by IN cord-001397-nrq4ncdf 113 19 enhancing enhance VBG cord-001397-nrq4ncdf 113 20 cleavage cleavage NN cord-001397-nrq4ncdf 113 21 of of IN cord-001397-nrq4ncdf 113 22 C4 c4 NN cord-001397-nrq4ncdf 113 23 through through IN cord-001397-nrq4ncdf 113 24 the the DT cord-001397-nrq4ncdf 113 25 recruitment recruitment NN cord-001397-nrq4ncdf 113 26 of of IN cord-001397-nrq4ncdf 113 27 the the DT cord-001397-nrq4ncdf 113 28 complement complement NN cord-001397-nrq4ncdf 113 29 - - HYPH cord-001397-nrq4ncdf 113 30 specific specific JJ cord-001397-nrq4ncdf 113 31 protease protease NN cord-001397-nrq4ncdf 113 32 C1s C1s . cord-001397-nrq4ncdf 114 1 ( ( -LRB- cord-001397-nrq4ncdf 114 2 Avirutnan Avirutnan NNP cord-001397-nrq4ncdf 114 3 et et NNP cord-001397-nrq4ncdf 114 4 al al NNP cord-001397-nrq4ncdf 114 5 . . NNP cord-001397-nrq4ncdf 114 6 , , , cord-001397-nrq4ncdf 114 7 2010 2010 CD cord-001397-nrq4ncdf 114 8 ) ) -RRB- cord-001397-nrq4ncdf 114 9 . . . cord-001397-nrq4ncdf 115 1 NS2A ns2a RB cord-001397-nrq4ncdf 116 1 ( ( -LRB- cord-001397-nrq4ncdf 116 2 Blitvich Blitvich NNP cord-001397-nrq4ncdf 116 3 et et NNP cord-001397-nrq4ncdf 116 4 al al NNP cord-001397-nrq4ncdf 116 5 . . NNP cord-001397-nrq4ncdf 116 6 , , , cord-001397-nrq4ncdf 116 7 1995 1995 CD cord-001397-nrq4ncdf 116 8 ( ( -LRB- cord-001397-nrq4ncdf 116 9 Blitvich Blitvich NNP cord-001397-nrq4ncdf 116 10 et et NNP cord-001397-nrq4ncdf 116 11 al al NNP cord-001397-nrq4ncdf 116 12 . . NNP cord-001397-nrq4ncdf 116 13 , , , cord-001397-nrq4ncdf 116 14 , , , cord-001397-nrq4ncdf 116 15 1999 1999 CD cord-001397-nrq4ncdf 117 1 ( ( -LRB- cord-001397-nrq4ncdf 117 2 Assenberg Assenberg NNP cord-001397-nrq4ncdf 117 3 et et NNP cord-001397-nrq4ncdf 117 4 al al NNP cord-001397-nrq4ncdf 117 5 . . NNP cord-001397-nrq4ncdf 117 6 , , , cord-001397-nrq4ncdf 117 7 2009 2009 CD cord-001397-nrq4ncdf 117 8 ) ) -RRB- cord-001397-nrq4ncdf 117 9 . . . cord-001397-nrq4ncdf 118 1 NS3 ns3 RB cord-001397-nrq4ncdf 118 2 is be VBZ cord-001397-nrq4ncdf 118 3 a a DT cord-001397-nrq4ncdf 118 4 highly highly RB cord-001397-nrq4ncdf 118 5 conserved conserved JJ cord-001397-nrq4ncdf 118 6 and and CC cord-001397-nrq4ncdf 118 7 multifunctional multifunctional JJ cord-001397-nrq4ncdf 118 8 protein protein NN cord-001397-nrq4ncdf 118 9 : : : cord-001397-nrq4ncdf 119 1 The the DT cord-001397-nrq4ncdf 119 2 protein protein NN cord-001397-nrq4ncdf 119 3 has have VBZ cord-001397-nrq4ncdf 119 4 protease protease NN cord-001397-nrq4ncdf 119 5 activity activity NN cord-001397-nrq4ncdf 119 6 in in IN cord-001397-nrq4ncdf 119 7 one one CD cord-001397-nrq4ncdf 119 8 domain domain NN cord-001397-nrq4ncdf 119 9 , , , cord-001397-nrq4ncdf 119 10 RNA RNA NNP cord-001397-nrq4ncdf 119 11 - - HYPH cord-001397-nrq4ncdf 119 12 stimulated stimulate VBN cord-001397-nrq4ncdf 119 13 NTPase NTPase NNP cord-001397-nrq4ncdf 119 14 activity activity NN cord-001397-nrq4ncdf 119 15 and and CC cord-001397-nrq4ncdf 119 16 RNA RNA NNP cord-001397-nrq4ncdf 119 17 triphosphate triphosphate NN cord-001397-nrq4ncdf 119 18 activity activity NN cord-001397-nrq4ncdf 119 19 ( ( -LRB- cord-001397-nrq4ncdf 119 20 RTPase RTPase NNP cord-001397-nrq4ncdf 119 21 ) ) -RRB- cord-001397-nrq4ncdf 119 22 in in IN cord-001397-nrq4ncdf 119 23 the the DT cord-001397-nrq4ncdf 119 24 other other JJ cord-001397-nrq4ncdf 119 25 domain domain NN cord-001397-nrq4ncdf 119 26 ( ( -LRB- cord-001397-nrq4ncdf 119 27 Chambers chamber NNS cord-001397-nrq4ncdf 119 28 et et NNP cord-001397-nrq4ncdf 119 29 al al NNP cord-001397-nrq4ncdf 119 30 . . NNP cord-001397-nrq4ncdf 119 31 , , , cord-001397-nrq4ncdf 119 32 1991 1991 CD cord-001397-nrq4ncdf 119 33 ; ; : cord-001397-nrq4ncdf 119 34 Valle Valle NNP cord-001397-nrq4ncdf 119 35 & & CC cord-001397-nrq4ncdf 119 36 Falgout Falgout NNP cord-001397-nrq4ncdf 119 37 , , , cord-001397-nrq4ncdf 119 38 1998 1998 CD cord-001397-nrq4ncdf 119 39 ; ; : cord-001397-nrq4ncdf 120 1 Lescar Lescar NNP cord-001397-nrq4ncdf 120 2 et et FW cord-001397-nrq4ncdf 120 3 al al NNP cord-001397-nrq4ncdf 120 4 . . NNP cord-001397-nrq4ncdf 120 5 , , , cord-001397-nrq4ncdf 120 6 2008 2008 CD cord-001397-nrq4ncdf 120 7 ) ) -RRB- cord-001397-nrq4ncdf 120 8 . . . cord-001397-nrq4ncdf 121 1 NS3 ns3 RB cord-001397-nrq4ncdf 121 2 protein protein NN cord-001397-nrq4ncdf 121 3 is be VBZ cord-001397-nrq4ncdf 121 4 an an DT cord-001397-nrq4ncdf 121 5 essential essential JJ cord-001397-nrq4ncdf 121 6 member member NN cord-001397-nrq4ncdf 121 7 of of IN cord-001397-nrq4ncdf 121 8 the the DT cord-001397-nrq4ncdf 121 9 RC RC NNP cord-001397-nrq4ncdf 121 10 and and CC cord-001397-nrq4ncdf 121 11 is be VBZ cord-001397-nrq4ncdf 121 12 activated activate VBN cord-001397-nrq4ncdf 121 13 in in IN cord-001397-nrq4ncdf 121 14 association association NN cord-001397-nrq4ncdf 121 15 with with IN cord-001397-nrq4ncdf 121 16 NS5 NS5 NNP cord-001397-nrq4ncdf 121 17 to to TO cord-001397-nrq4ncdf 121 18 bind bind VB cord-001397-nrq4ncdf 121 19 the the DT cord-001397-nrq4ncdf 121 20 genomic genomic JJ cord-001397-nrq4ncdf 121 21 RNA RNA NNP cord-001397-nrq4ncdf 121 22 3 3 CD cord-001397-nrq4ncdf 121 23 0 0 CD cord-001397-nrq4ncdf 121 24 SL SL NNP cord-001397-nrq4ncdf 121 25 prior prior RB cord-001397-nrq4ncdf 121 26 to to IN cord-001397-nrq4ncdf 121 27 replication replication NN cord-001397-nrq4ncdf 122 1 ( ( -LRB- cord-001397-nrq4ncdf 122 2 Chen Chen NNP cord-001397-nrq4ncdf 122 3 et et NNP cord-001397-nrq4ncdf 122 4 al al NNP cord-001397-nrq4ncdf 122 5 . . NNP cord-001397-nrq4ncdf 122 6 , , , cord-001397-nrq4ncdf 122 7 1997 1997 CD cord-001397-nrq4ncdf 122 8 ; ; : cord-001397-nrq4ncdf 122 9 Mackenzie Mackenzie NNP cord-001397-nrq4ncdf 122 10 et et NNP cord-001397-nrq4ncdf 122 11 al al NNP cord-001397-nrq4ncdf 122 12 . . NNP cord-001397-nrq4ncdf 122 13 , , , cord-001397-nrq4ncdf 122 14 1998 1998 CD cord-001397-nrq4ncdf 122 15 ; ; : cord-001397-nrq4ncdf 123 1 Lindenbach Lindenbach NNP cord-001397-nrq4ncdf 123 2 et et NNP cord-001397-nrq4ncdf 123 3 al al NNP cord-001397-nrq4ncdf 123 4 . . NNP cord-001397-nrq4ncdf 123 5 , , , cord-001397-nrq4ncdf 123 6 2007 2007 CD cord-001397-nrq4ncdf 123 7 ) ) -RRB- cord-001397-nrq4ncdf 123 8 . . . cord-001397-nrq4ncdf 124 1 Beside beside IN cord-001397-nrq4ncdf 124 2 its -PRON- PRP$ cord-001397-nrq4ncdf 124 3 essential essential JJ cord-001397-nrq4ncdf 124 4 role role NN cord-001397-nrq4ncdf 124 5 in in IN cord-001397-nrq4ncdf 124 6 the the DT cord-001397-nrq4ncdf 124 7 viral viral JJ cord-001397-nrq4ncdf 124 8 replication replication NN cord-001397-nrq4ncdf 124 9 cycle cycle NN cord-001397-nrq4ncdf 124 10 , , , cord-001397-nrq4ncdf 124 11 NS3 ns3 RB cord-001397-nrq4ncdf 124 12 can can MD cord-001397-nrq4ncdf 124 13 also also RB cord-001397-nrq4ncdf 124 14 induce induce VB cord-001397-nrq4ncdf 124 15 apoptosis apoptosis NN cord-001397-nrq4ncdf 124 16 ( ( -LRB- cord-001397-nrq4ncdf 124 17 Shafee Shafee NNP cord-001397-nrq4ncdf 124 18 & & CC cord-001397-nrq4ncdf 124 19 AbuBakar AbuBakar NNP cord-001397-nrq4ncdf 124 20 , , , cord-001397-nrq4ncdf 124 21 2003 2003 CD cord-001397-nrq4ncdf 124 22 ; ; : cord-001397-nrq4ncdf 124 23 Ramanathan Ramanathan NNP cord-001397-nrq4ncdf 124 24 et et NNP cord-001397-nrq4ncdf 124 25 al al NNP cord-001397-nrq4ncdf 124 26 . . NNP cord-001397-nrq4ncdf 124 27 , , , cord-001397-nrq4ncdf 124 28 2006 2006 CD cord-001397-nrq4ncdf 124 29 ; ; . cord-001397-nrq4ncdf 125 1 Yang Yang NNP cord-001397-nrq4ncdf 125 2 et et NNP cord-001397-nrq4ncdf 125 3 al al NNP cord-001397-nrq4ncdf 125 4 . . . cord-001397-nrq4ncdf 126 1 , , , cord-001397-nrq4ncdf 126 2 2009 2009 CD cord-001397-nrq4ncdf 126 3 ; ; : cord-001397-nrq4ncdf 126 4 Yiang Yiang NNP cord-001397-nrq4ncdf 126 5 et et NNP cord-001397-nrq4ncdf 126 6 al al NNP cord-001397-nrq4ncdf 126 7 . . NNP cord-001397-nrq4ncdf 126 8 , , , cord-001397-nrq4ncdf 126 9 2013 2013 CD cord-001397-nrq4ncdf 126 10 ) ) -RRB- cord-001397-nrq4ncdf 126 11 . . . cord-001397-nrq4ncdf 127 1 NS3 ns3 RB cord-001397-nrq4ncdf 127 2 is be VBZ cord-001397-nrq4ncdf 127 3 involved involve VBN cord-001397-nrq4ncdf 127 4 in in IN cord-001397-nrq4ncdf 127 5 the the DT cord-001397-nrq4ncdf 127 6 inhibition inhibition NN cord-001397-nrq4ncdf 127 7 of of IN cord-001397-nrq4ncdf 127 8 the the DT cord-001397-nrq4ncdf 127 9 transcriptional transcriptional JJ cord-001397-nrq4ncdf 127 10 factor factor NN cord-001397-nrq4ncdf 127 11 AP1 AP1 NNP cord-001397-nrq4ncdf 127 12 signaling signal VBG cord-001397-nrq4ncdf 127 13 pathway pathway NN cord-001397-nrq4ncdf 127 14 , , , cord-001397-nrq4ncdf 127 15 which which WDT cord-001397-nrq4ncdf 127 16 also also RB cord-001397-nrq4ncdf 127 17 directly directly RB cord-001397-nrq4ncdf 127 18 affects affect VBZ cord-001397-nrq4ncdf 127 19 apoptosis apoptosis NN cord-001397-nrq4ncdf 127 20 ( ( -LRB- cord-001397-nrq4ncdf 127 21 Lin Lin NNP cord-001397-nrq4ncdf 127 22 et et NNP cord-001397-nrq4ncdf 127 23 al al NNP cord-001397-nrq4ncdf 127 24 . . NNP cord-001397-nrq4ncdf 127 25 , , , cord-001397-nrq4ncdf 127 26 2006 2006 CD cord-001397-nrq4ncdf 127 27 ) ) -RRB- cord-001397-nrq4ncdf 127 28 . . . cord-001397-nrq4ncdf 128 1 Studies study NNS cord-001397-nrq4ncdf 128 2 on on IN cord-001397-nrq4ncdf 128 3 neurovirulence neurovirulence NNP cord-001397-nrq4ncdf 128 4 associated associate VBN cord-001397-nrq4ncdf 128 5 with with IN cord-001397-nrq4ncdf 128 6 DENV-1 DENV-1 NNS cord-001397-nrq4ncdf 128 7 NS3 ns3 RB cord-001397-nrq4ncdf 128 8 have have VBP cord-001397-nrq4ncdf 128 9 shown show VBN cord-001397-nrq4ncdf 128 10 that that IN cord-001397-nrq4ncdf 128 11 mutations mutation NNS cord-001397-nrq4ncdf 128 12 in in IN cord-001397-nrq4ncdf 128 13 NS3 ns3 RB cord-001397-nrq4ncdf 128 14 ( ( -LRB- cord-001397-nrq4ncdf 128 15 Leu480Ser leu480ser UH cord-001397-nrq4ncdf 128 16 ) ) -RRB- cord-001397-nrq4ncdf 128 17 enhance enhance VB cord-001397-nrq4ncdf 128 18 the the DT cord-001397-nrq4ncdf 128 19 ability ability NN cord-001397-nrq4ncdf 128 20 of of IN cord-001397-nrq4ncdf 128 21 replication replication NN cord-001397-nrq4ncdf 128 22 in in IN cord-001397-nrq4ncdf 128 23 CNS CNS NNP cord-001397-nrq4ncdf 128 24 causing cause VBG cord-001397-nrq4ncdf 128 25 leptomeningitis leptomeningitis NN cord-001397-nrq4ncdf 128 26 and and CC cord-001397-nrq4ncdf 128 27 encephalitis encephalitis JJ cord-001397-nrq4ncdf 128 28 in in IN cord-001397-nrq4ncdf 128 29 mice mouse NNS cord-001397-nrq4ncdf 128 30 ( ( -LRB- cord-001397-nrq4ncdf 128 31 Bordignon Bordignon NNP cord-001397-nrq4ncdf 128 32 et et FW cord-001397-nrq4ncdf 128 33 al al NNP cord-001397-nrq4ncdf 128 34 . . NNP cord-001397-nrq4ncdf 128 35 , , , cord-001397-nrq4ncdf 128 36 2007 2007 CD cord-001397-nrq4ncdf 128 37 ) ) -RRB- cord-001397-nrq4ncdf 128 38 . . . cord-001397-nrq4ncdf 129 1 This this DT cord-001397-nrq4ncdf 129 2 mutation mutation NN cord-001397-nrq4ncdf 129 3 was be VBD cord-001397-nrq4ncdf 129 4 also also RB cord-001397-nrq4ncdf 129 5 shown show VBN cord-001397-nrq4ncdf 129 6 to to TO cord-001397-nrq4ncdf 129 7 induce induce VB cord-001397-nrq4ncdf 129 8 cell cell NN cord-001397-nrq4ncdf 129 9 death death NN cord-001397-nrq4ncdf 129 10 in in IN cord-001397-nrq4ncdf 129 11 DENV-1-infected denv-1-infected JJ cord-001397-nrq4ncdf 129 12 cells cell NNS cord-001397-nrq4ncdf 129 13 ( ( -LRB- cord-001397-nrq4ncdf 130 1 Duarte Duarte NNP cord-001397-nrq4ncdf 130 2 dos do NNS cord-001397-nrq4ncdf 130 3 Santos Santos NNP cord-001397-nrq4ncdf 130 4 et et FW cord-001397-nrq4ncdf 130 5 al al NNP cord-001397-nrq4ncdf 130 6 . . . cord-001397-nrq4ncdf 131 1 , , , cord-001397-nrq4ncdf 131 2 2000 2000 CD cord-001397-nrq4ncdf 131 3 ) ) -RRB- cord-001397-nrq4ncdf 131 4 . . . cord-001397-nrq4ncdf 132 1 The the DT cord-001397-nrq4ncdf 132 2 NS3 ns3 RB cord-001397-nrq4ncdf 132 3 protein protein NN cord-001397-nrq4ncdf 132 4 can can MD cord-001397-nrq4ncdf 132 5 be be VB cord-001397-nrq4ncdf 132 6 targeted target VBN cord-001397-nrq4ncdf 132 7 by by IN cord-001397-nrq4ncdf 132 8 antiviral antiviral JJ cord-001397-nrq4ncdf 132 9 drugs drug NNS cord-001397-nrq4ncdf 132 10 such such JJ cord-001397-nrq4ncdf 132 11 as as IN cord-001397-nrq4ncdf 132 12 ivermectin ivermectin NNP cord-001397-nrq4ncdf 132 13 , , , cord-001397-nrq4ncdf 132 14 ribavirin ribavirin RB cord-001397-nrq4ncdf 132 15 as as IN cord-001397-nrq4ncdf 132 16 inhibitors inhibitor NNS cord-001397-nrq4ncdf 132 17 of of IN cord-001397-nrq4ncdf 132 18 the the DT cord-001397-nrq4ncdf 132 19 ATPase ATPase NNP cord-001397-nrq4ncdf 132 20 activity activity NN cord-001397-nrq4ncdf 132 21 of of IN cord-001397-nrq4ncdf 132 22 helicases helicase NNS cord-001397-nrq4ncdf 132 23 ( ( -LRB- cord-001397-nrq4ncdf 132 24 Mastrangelo Mastrangelo NNP cord-001397-nrq4ncdf 132 25 et et NNP cord-001397-nrq4ncdf 132 26 al al NNP cord-001397-nrq4ncdf 132 27 . . NNP cord-001397-nrq4ncdf 132 28 , , , cord-001397-nrq4ncdf 132 29 2012 2012 CD cord-001397-nrq4ncdf 132 30 ) ) -RRB- cord-001397-nrq4ncdf 133 1 The the DT cord-001397-nrq4ncdf 133 2 ( ( -LRB- cord-001397-nrq4ncdf 133 3 Lindenbach Lindenbach NNP cord-001397-nrq4ncdf 133 4 et et NNP cord-001397-nrq4ncdf 133 5 al al NNP cord-001397-nrq4ncdf 133 6 . . NNP cord-001397-nrq4ncdf 133 7 , , , cord-001397-nrq4ncdf 133 8 2007 2007 CD cord-001397-nrq4ncdf 133 9 ) ) -RRB- cord-001397-nrq4ncdf 133 10 . . . cord-001397-nrq4ncdf 134 1 Its -PRON- PRP$ cord-001397-nrq4ncdf 134 2 interaction interaction NN cord-001397-nrq4ncdf 134 3 with with IN cord-001397-nrq4ncdf 134 4 NS1 NS1 NNS cord-001397-nrq4ncdf 134 5 is be VBZ cord-001397-nrq4ncdf 134 6 essential essential JJ cord-001397-nrq4ncdf 134 7 for for IN cord-001397-nrq4ncdf 134 8 viral viral JJ cord-001397-nrq4ncdf 134 9 RNA RNA NNP cord-001397-nrq4ncdf 134 10 replication replication NN cord-001397-nrq4ncdf 134 11 as as IN cord-001397-nrq4ncdf 134 12 NS4A NS4A NNP cord-001397-nrq4ncdf 134 13 acts act NNS cord-001397-nrq4ncdf 134 14 as as IN cord-001397-nrq4ncdf 134 15 a a DT cord-001397-nrq4ncdf 134 16 docking docking NN cord-001397-nrq4ncdf 134 17 site site NN cord-001397-nrq4ncdf 134 18 ( ( -LRB- cord-001397-nrq4ncdf 134 19 Bartenschlager Bartenschlager NNP cord-001397-nrq4ncdf 134 20 et et NNP cord-001397-nrq4ncdf 134 21 al al NNP cord-001397-nrq4ncdf 134 22 . . NNP cord-001397-nrq4ncdf 134 23 , , , cord-001397-nrq4ncdf 134 24 1995 1995 CD cord-001397-nrq4ncdf 134 25 ; ; : cord-001397-nrq4ncdf 134 26 Miller Miller NNP cord-001397-nrq4ncdf 134 27 et et NNP cord-001397-nrq4ncdf 134 28 al al NNP cord-001397-nrq4ncdf 134 29 . . NNP cord-001397-nrq4ncdf 134 30 , , , cord-001397-nrq4ncdf 134 31 2007 2007 CD cord-001397-nrq4ncdf 134 32 ) ) -RRB- cord-001397-nrq4ncdf 134 33 . . . cord-001397-nrq4ncdf 135 1 NS4A NS4A NNP cord-001397-nrq4ncdf 135 2 interacts interact VBZ cord-001397-nrq4ncdf 135 3 with with IN cord-001397-nrq4ncdf 135 4 the the DT cord-001397-nrq4ncdf 135 5 polypyrimidine polypyrimidine JJ cord-001397-nrq4ncdf 135 6 tract tract NN cord-001397-nrq4ncdf 135 7 - - HYPH cord-001397-nrq4ncdf 135 8 binding bind VBG cord-001397-nrq4ncdf 135 9 protein protein NN cord-001397-nrq4ncdf 135 10 ( ( -LRB- cord-001397-nrq4ncdf 135 11 PTB PTB NNP cord-001397-nrq4ncdf 135 12 ) ) -RRB- cord-001397-nrq4ncdf 135 13 , , , cord-001397-nrq4ncdf 135 14 with with IN cord-001397-nrq4ncdf 135 15 the the DT cord-001397-nrq4ncdf 135 16 latter latter JJ cord-001397-nrq4ncdf 135 17 being be VBG cord-001397-nrq4ncdf 135 18 implicated implicate VBN cord-001397-nrq4ncdf 135 19 in in IN cord-001397-nrq4ncdf 135 20 translation translation NN cord-001397-nrq4ncdf 135 21 , , , cord-001397-nrq4ncdf 135 22 transcription transcription NN cord-001397-nrq4ncdf 135 23 , , , cord-001397-nrq4ncdf 135 24 and and CC cord-001397-nrq4ncdf 135 25 viral viral JJ cord-001397-nrq4ncdf 135 26 processes process NNS cord-001397-nrq4ncdf 135 27 for for IN cord-001397-nrq4ncdf 135 28 various various JJ cord-001397-nrq4ncdf 135 29 viruses virus NNS cord-001397-nrq4ncdf 135 30 ( ( -LRB- cord-001397-nrq4ncdf 135 31 Bieleski Bieleski NNP cord-001397-nrq4ncdf 135 32 et et FW cord-001397-nrq4ncdf 135 33 al al NNP cord-001397-nrq4ncdf 135 34 . . NNP cord-001397-nrq4ncdf 135 35 , , , cord-001397-nrq4ncdf 135 36 2004 2004 CD cord-001397-nrq4ncdf 135 37 ; ; : cord-001397-nrq4ncdf 135 38 Florez Florez NNP cord-001397-nrq4ncdf 135 39 et et FW cord-001397-nrq4ncdf 135 40 al al NNP cord-001397-nrq4ncdf 135 41 . . NNP cord-001397-nrq4ncdf 135 42 , , , cord-001397-nrq4ncdf 135 43 2005 2005 CD cord-001397-nrq4ncdf 135 44 ; ; : cord-001397-nrq4ncdf 135 45 Shi Shi NNP cord-001397-nrq4ncdf 135 46 & & CC cord-001397-nrq4ncdf 135 47 Lai Lai NNP cord-001397-nrq4ncdf 135 48 , , , cord-001397-nrq4ncdf 135 49 2005 2005 CD cord-001397-nrq4ncdf 135 50 ) ) -RRB- cord-001397-nrq4ncdf 135 51 including include VBG cord-001397-nrq4ncdf 135 52 the the DT cord-001397-nrq4ncdf 135 53 role role NN cord-001397-nrq4ncdf 135 54 in in IN cord-001397-nrq4ncdf 135 55 regulation regulation NN cord-001397-nrq4ncdf 135 56 of of IN cord-001397-nrq4ncdf 135 57 HCV HCV NNP cord-001397-nrq4ncdf 135 58 replication replication NN cord-001397-nrq4ncdf 135 59 ( ( -LRB- cord-001397-nrq4ncdf 135 60 Tischendorf Tischendorf NNP cord-001397-nrq4ncdf 135 61 et et NNP cord-001397-nrq4ncdf 135 62 al al NNP cord-001397-nrq4ncdf 135 63 . . NNP cord-001397-nrq4ncdf 135 64 , , , cord-001397-nrq4ncdf 135 65 2004 2004 CD cord-001397-nrq4ncdf 135 66 ; ; : cord-001397-nrq4ncdf 135 67 Domitrovich Domitrovich NNP cord-001397-nrq4ncdf 135 68 et et NNP cord-001397-nrq4ncdf 135 69 al al NNP cord-001397-nrq4ncdf 135 70 . . NNP cord-001397-nrq4ncdf 135 71 , , , cord-001397-nrq4ncdf 135 72 2005 2005 CD cord-001397-nrq4ncdf 135 73 ; ; : cord-001397-nrq4ncdf 135 74 Aizaki Aizaki NNP cord-001397-nrq4ncdf 135 75 et et NNP cord-001397-nrq4ncdf 135 76 al al NNP cord-001397-nrq4ncdf 135 77 . . NNP cord-001397-nrq4ncdf 135 78 , , , cord-001397-nrq4ncdf 135 79 2006 2006 CD cord-001397-nrq4ncdf 135 80 ; ; : cord-001397-nrq4ncdf 135 81 Chang Chang NNP cord-001397-nrq4ncdf 135 82 & & CC cord-001397-nrq4ncdf 135 83 Luo Luo NNP cord-001397-nrq4ncdf 135 84 , , , cord-001397-nrq4ncdf 135 85 2006 2006 CD cord-001397-nrq4ncdf 135 86 ) ) -RRB- cord-001397-nrq4ncdf 135 87 . . . cord-001397-nrq4ncdf 136 1 NS4A NS4A NNP cord-001397-nrq4ncdf 136 2 - - HYPH cord-001397-nrq4ncdf 136 3 PTB PTB NNP cord-001397-nrq4ncdf 136 4 plays play VBZ cord-001397-nrq4ncdf 136 5 an an DT cord-001397-nrq4ncdf 136 6 indirect indirect JJ cord-001397-nrq4ncdf 136 7 role role NN cord-001397-nrq4ncdf 136 8 in in IN cord-001397-nrq4ncdf 136 9 stabilization stabilization NN cord-001397-nrq4ncdf 136 10 of of IN cord-001397-nrq4ncdf 136 11 the the DT cord-001397-nrq4ncdf 136 12 viral viral JJ cord-001397-nrq4ncdf 136 13 genome genome NN cord-001397-nrq4ncdf 136 14 dsRNA dsrna NN cord-001397-nrq4ncdf 137 1 intermediates intermediate NNS cord-001397-nrq4ncdf 137 2 by by IN cord-001397-nrq4ncdf 137 3 binding bind VBG cord-001397-nrq4ncdf 137 4 to to IN cord-001397-nrq4ncdf 137 5 host host VB cord-001397-nrq4ncdf 137 6 cell cell NN cord-001397-nrq4ncdf 137 7 PTB PTB NNP cord-001397-nrq4ncdf 137 8 protein protein NN cord-001397-nrq4ncdf 137 9 in in IN cord-001397-nrq4ncdf 137 10 a a DT cord-001397-nrq4ncdf 137 11 similar similar JJ cord-001397-nrq4ncdf 137 12 manner manner NN cord-001397-nrq4ncdf 137 13 as as IN cord-001397-nrq4ncdf 137 14 stabilizing stabilize VBG cord-001397-nrq4ncdf 137 15 WNV WNV NNP cord-001397-nrq4ncdf 137 16 RNA RNA NNP cord-001397-nrq4ncdf 137 17 synthesis synthesis NN cord-001397-nrq4ncdf 137 18 by by IN cord-001397-nrq4ncdf 137 19 the the DT cord-001397-nrq4ncdf 137 20 elongation elongation NN cord-001397-nrq4ncdf 137 21 factor factor NN cord-001397-nrq4ncdf 137 22 1 1 CD cord-001397-nrq4ncdf 137 23 alpha alpha NN cord-001397-nrq4ncdf 138 1 ( ( -LRB- cord-001397-nrq4ncdf 138 2 Davis Davis NNP cord-001397-nrq4ncdf 138 3 et et NNP cord-001397-nrq4ncdf 138 4 al al NNP cord-001397-nrq4ncdf 138 5 . . NNP cord-001397-nrq4ncdf 138 6 , , , cord-001397-nrq4ncdf 138 7 2007 2007 CD cord-001397-nrq4ncdf 139 1 ; ; : cord-001397-nrq4ncdf 139 2 Jiang Jiang NNP cord-001397-nrq4ncdf 139 3 et et FW cord-001397-nrq4ncdf 139 4 al al NNP cord-001397-nrq4ncdf 139 5 . . NNP cord-001397-nrq4ncdf 139 6 , , , cord-001397-nrq4ncdf 139 7 2009 2009 CD cord-001397-nrq4ncdf 139 8 ) ) -RRB- cord-001397-nrq4ncdf 139 9 . . . cord-001397-nrq4ncdf 140 1 NS4A ns4a VB cord-001397-nrq4ncdf 140 2 together together RB cord-001397-nrq4ncdf 140 3 with with IN cord-001397-nrq4ncdf 140 4 NS4B NS4B NNP cord-001397-nrq4ncdf 140 5 and and CC cord-001397-nrq4ncdf 140 6 NS3 ns3 RB cord-001397-nrq4ncdf 140 7 is be VBZ cord-001397-nrq4ncdf 140 8 also also RB cord-001397-nrq4ncdf 140 9 responsible responsible JJ cord-001397-nrq4ncdf 140 10 for for IN cord-001397-nrq4ncdf 140 11 inducing induce VBG cord-001397-nrq4ncdf 140 12 the the DT cord-001397-nrq4ncdf 140 13 rearrangement rearrangement NN cord-001397-nrq4ncdf 140 14 of of IN cord-001397-nrq4ncdf 140 15 the the DT cord-001397-nrq4ncdf 140 16 host host NN cord-001397-nrq4ncdf 140 17 ER ER NNP cord-001397-nrq4ncdf 140 18 membrane membrane NN cord-001397-nrq4ncdf 140 19 leading lead VBG cord-001397-nrq4ncdf 140 20 to to IN cord-001397-nrq4ncdf 140 21 the the DT cord-001397-nrq4ncdf 140 22 formation formation NN cord-001397-nrq4ncdf 140 23 of of IN cord-001397-nrq4ncdf 140 24 virus virus NN cord-001397-nrq4ncdf 140 25 - - HYPH cord-001397-nrq4ncdf 140 26 induced induce VBN cord-001397-nrq4ncdf 140 27 membranous membranous JJ cord-001397-nrq4ncdf 140 28 spherules spherule NNS cord-001397-nrq4ncdf 140 29 and and CC cord-001397-nrq4ncdf 140 30 vesicles vesicle NNS cord-001397-nrq4ncdf 140 31 encasing encase VBG cord-001397-nrq4ncdf 140 32 the the DT cord-001397-nrq4ncdf 140 33 dsRNA dsrna NN cord-001397-nrq4ncdf 140 34 and and CC cord-001397-nrq4ncdf 140 35 RC rc NN cord-001397-nrq4ncdf 140 36 ; ; : cord-001397-nrq4ncdf 140 37 this this DT cord-001397-nrq4ncdf 140 38 is be VBZ cord-001397-nrq4ncdf 140 39 thought think VBN cord-001397-nrq4ncdf 140 40 to to TO cord-001397-nrq4ncdf 140 41 minimize minimize VB cord-001397-nrq4ncdf 140 42 exposure exposure NN cord-001397-nrq4ncdf 140 43 of of IN cord-001397-nrq4ncdf 140 44 the the DT cord-001397-nrq4ncdf 140 45 replicating replicate VBG cord-001397-nrq4ncdf 140 46 RNA RNA NNP cord-001397-nrq4ncdf 140 47 to to TO cord-001397-nrq4ncdf 140 48 innate innate VB cord-001397-nrq4ncdf 140 49 immune immune JJ cord-001397-nrq4ncdf 140 50 sensors sensor NNS cord-001397-nrq4ncdf 140 51 such such JJ cord-001397-nrq4ncdf 140 52 as as IN cord-001397-nrq4ncdf 140 53 retinoic retinoic JJ cord-001397-nrq4ncdf 140 54 acid acid NN cord-001397-nrq4ncdf 140 55 - - HYPH cord-001397-nrq4ncdf 140 56 inducible inducible JJ cord-001397-nrq4ncdf 140 57 gene gene NN cord-001397-nrq4ncdf 140 58 - - : cord-001397-nrq4ncdf 140 59 I I NNP cord-001397-nrq4ncdf 140 60 , , , cord-001397-nrq4ncdf 140 61 RIG rig NN cord-001397-nrq4ncdf 140 62 - - : cord-001397-nrq4ncdf 140 63 I -PRON- PRP cord-001397-nrq4ncdf 140 64 Roosendaal Roosendaal NNP cord-001397-nrq4ncdf 140 65 et et NNP cord-001397-nrq4ncdf 140 66 al al NNP cord-001397-nrq4ncdf 140 67 . . NNP cord-001397-nrq4ncdf 140 68 , , , cord-001397-nrq4ncdf 140 69 2006 2006 CD cord-001397-nrq4ncdf 140 70 ; ; . cord-001397-nrq4ncdf 141 1 Miller Miller NNP cord-001397-nrq4ncdf 141 2 et et NNP cord-001397-nrq4ncdf 141 3 al al NNP cord-001397-nrq4ncdf 141 4 . . NNP cord-001397-nrq4ncdf 141 5 , , , cord-001397-nrq4ncdf 141 6 2007 2007 CD cord-001397-nrq4ncdf 141 7 ) ) -RRB- cord-001397-nrq4ncdf 141 8 . . . cord-001397-nrq4ncdf 142 1 The the DT cord-001397-nrq4ncdf 142 2 mature mature JJ cord-001397-nrq4ncdf 142 3 NS4A ns4a NN cord-001397-nrq4ncdf 142 4 can can MD cord-001397-nrq4ncdf 142 5 also also RB cord-001397-nrq4ncdf 142 6 induce induce VB cord-001397-nrq4ncdf 142 7 the the DT cord-001397-nrq4ncdf 142 8 PI3K pi3k NN cord-001397-nrq4ncdf 142 9 - - HYPH cord-001397-nrq4ncdf 142 10 dependent dependent JJ cord-001397-nrq4ncdf 142 11 autophagy autophagy NN cord-001397-nrq4ncdf 142 12 signaling signal VBG cord-001397-nrq4ncdf 142 13 , , , cord-001397-nrq4ncdf 142 14 which which WDT cord-001397-nrq4ncdf 142 15 in in IN cord-001397-nrq4ncdf 142 16 turn turn NN cord-001397-nrq4ncdf 142 17 lead lead RB cord-001397-nrq4ncdf 142 18 to to IN cord-001397-nrq4ncdf 142 19 protection protection NN cord-001397-nrq4ncdf 142 20 from from IN cord-001397-nrq4ncdf 142 21 camptothecin camptothecin NNS cord-001397-nrq4ncdf 142 22 - - : cord-001397-nrq4ncdf 142 23 and and CC cord-001397-nrq4ncdf 142 24 staurosporine staurosporine JJ cord-001397-nrq4ncdf 142 25 - - HYPH cord-001397-nrq4ncdf 142 26 induced induce VBN cord-001397-nrq4ncdf 142 27 cell cell NN cord-001397-nrq4ncdf 142 28 death death NN cord-001397-nrq4ncdf 143 1 ( ( -LRB- cord-001397-nrq4ncdf 143 2 McLean McLean NNP cord-001397-nrq4ncdf 143 3 et et NNP cord-001397-nrq4ncdf 143 4 al al NNP cord-001397-nrq4ncdf 143 5 . . NNP cord-001397-nrq4ncdf 143 6 , , , cord-001397-nrq4ncdf 143 7 2011 2011 CD cord-001397-nrq4ncdf 143 8 ) ) -RRB- cord-001397-nrq4ncdf 143 9 . . . cord-001397-nrq4ncdf 144 1 The the DT cord-001397-nrq4ncdf 144 2 role role NN cord-001397-nrq4ncdf 144 3 of of IN cord-001397-nrq4ncdf 144 4 NS4A NS4A NNP cord-001397-nrq4ncdf 144 5 in in IN cord-001397-nrq4ncdf 144 6 the the DT cord-001397-nrq4ncdf 144 7 up up JJ cord-001397-nrq4ncdf 144 8 - - HYPH cord-001397-nrq4ncdf 144 9 regulation regulation NN cord-001397-nrq4ncdf 144 10 of of IN cord-001397-nrq4ncdf 144 11 the the DT cord-001397-nrq4ncdf 144 12 autophagy autophagy NN cord-001397-nrq4ncdf 144 13 and and CC cord-001397-nrq4ncdf 144 14 ER ER NNP cord-001397-nrq4ncdf 144 15 rearrangement rearrangement NN cord-001397-nrq4ncdf 144 16 makes make VBZ cord-001397-nrq4ncdf 144 17 the the DT cord-001397-nrq4ncdf 144 18 protein protein NN cord-001397-nrq4ncdf 144 19 a a DT cord-001397-nrq4ncdf 144 20 potential potential JJ cord-001397-nrq4ncdf 144 21 target target NN cord-001397-nrq4ncdf 144 22 for for IN cord-001397-nrq4ncdf 144 23 antiviral antiviral JJ cord-001397-nrq4ncdf 144 24 drug drug NN cord-001397-nrq4ncdf 144 25 development development NN cord-001397-nrq4ncdf 144 26 † † NN cord-001397-nrq4ncdf 144 27 2 2 CD cord-001397-nrq4ncdf 144 28 K K NNP cord-001397-nrq4ncdf 144 29 6841 6841 CD cord-001397-nrq4ncdf 144 30 - - HYPH cord-001397-nrq4ncdf 144 31 6909 6909 CD cord-001397-nrq4ncdf 144 32 , , , cord-001397-nrq4ncdf 144 33 2 2 CD cord-001397-nrq4ncdf 144 34 kDa kDa NNPS cord-001397-nrq4ncdf 144 35 , , , cord-001397-nrq4ncdf 144 36 23 23 CD cord-001397-nrq4ncdf 144 37 aa aa NNP cord-001397-nrq4ncdf 144 38 Complete Complete NNP cord-001397-nrq4ncdf 144 39 cleavage cleavage NN cord-001397-nrq4ncdf 144 40 of of IN cord-001397-nrq4ncdf 144 41 the the DT cord-001397-nrq4ncdf 144 42 VBFV VBFV NNP cord-001397-nrq4ncdf 144 43 polyprotein polyprotein NN cord-001397-nrq4ncdf 144 44 generates generate VBZ cord-001397-nrq4ncdf 144 45 an an DT cord-001397-nrq4ncdf 144 46 ER ER NNP cord-001397-nrq4ncdf 144 47 - - HYPH cord-001397-nrq4ncdf 144 48 spanning span VBG cord-001397-nrq4ncdf 144 49 2 2 CD cord-001397-nrq4ncdf 144 50 K k NN cord-001397-nrq4ncdf 144 51 peptide peptide NN cord-001397-nrq4ncdf 144 52 located locate VBN cord-001397-nrq4ncdf 144 53 between between IN cord-001397-nrq4ncdf 144 54 NS4A NS4A NNP cord-001397-nrq4ncdf 144 55 and and CC cord-001397-nrq4ncdf 144 56 NS4B NS4B NNP cord-001397-nrq4ncdf 145 1 ( ( -LRB- cord-001397-nrq4ncdf 145 2 Lin Lin NNP cord-001397-nrq4ncdf 145 3 et et NNP cord-001397-nrq4ncdf 145 4 al al NNP cord-001397-nrq4ncdf 145 5 . . . cord-001397-nrq4ncdf 146 1 , , , cord-001397-nrq4ncdf 146 2 1993 1993 CD cord-001397-nrq4ncdf 146 3 ; ; : cord-001397-nrq4ncdf 146 4 Roosendaal Roosendaal NNP cord-001397-nrq4ncdf 146 5 et et NNP cord-001397-nrq4ncdf 146 6 al al NNP cord-001397-nrq4ncdf 146 7 . . NNP cord-001397-nrq4ncdf 146 8 , , , cord-001397-nrq4ncdf 146 9 2006 2006 CD cord-001397-nrq4ncdf 146 10 ; ; : cord-001397-nrq4ncdf 146 11 Miller Miller NNP cord-001397-nrq4ncdf 146 12 et et NNP cord-001397-nrq4ncdf 146 13 al al NNP cord-001397-nrq4ncdf 146 14 . . NNP cord-001397-nrq4ncdf 146 15 , , , cord-001397-nrq4ncdf 146 16 2007 2007 CD cord-001397-nrq4ncdf 146 17 ) ) -RRB- cord-001397-nrq4ncdf 146 18 . . . cord-001397-nrq4ncdf 147 1 The the DT cord-001397-nrq4ncdf 147 2 2 2 CD cord-001397-nrq4ncdf 147 3 K K NNP cord-001397-nrq4ncdf 147 4 peptide peptide NN cord-001397-nrq4ncdf 147 5 functions function NNS cord-001397-nrq4ncdf 147 6 as as IN cord-001397-nrq4ncdf 147 7 a a DT cord-001397-nrq4ncdf 147 8 signal signal JJ cord-001397-nrq4ncdf 147 9 peptide peptide NN cord-001397-nrq4ncdf 147 10 for for IN cord-001397-nrq4ncdf 147 11 NS4B NS4B NNP cord-001397-nrq4ncdf 147 12 and and CC cord-001397-nrq4ncdf 147 13 might may MD cord-001397-nrq4ncdf 147 14 play play VB cord-001397-nrq4ncdf 147 15 a a DT cord-001397-nrq4ncdf 147 16 role role NN cord-001397-nrq4ncdf 147 17 in in IN cord-001397-nrq4ncdf 147 18 enhancing enhance VBG cord-001397-nrq4ncdf 147 19 viral viral JJ cord-001397-nrq4ncdf 147 20 replication replication NN cord-001397-nrq4ncdf 147 21 by by IN cord-001397-nrq4ncdf 147 22 conferring confer VBG cord-001397-nrq4ncdf 147 23 resistance resistance NN cord-001397-nrq4ncdf 147 24 to to IN cord-001397-nrq4ncdf 147 25 lycorine lycorine NNP cord-001397-nrq4ncdf 147 26 , , , cord-001397-nrq4ncdf 147 27 a a DT cord-001397-nrq4ncdf 147 28 suppressor suppressor NN cord-001397-nrq4ncdf 147 29 of of IN cord-001397-nrq4ncdf 147 30 flavivirus flavivirus NNP cord-001397-nrq4ncdf 147 31 RNA RNA NNP cord-001397-nrq4ncdf 147 32 synthesis synthesis NN cord-001397-nrq4ncdf 147 33 ( ( -LRB- cord-001397-nrq4ncdf 148 1 Zou Zou NNP cord-001397-nrq4ncdf 148 2 et et FW cord-001397-nrq4ncdf 148 3 al al NNP cord-001397-nrq4ncdf 148 4 . . NNP cord-001397-nrq4ncdf 148 5 , , , cord-001397-nrq4ncdf 148 6 2009 2009 CD cord-001397-nrq4ncdf 148 7 ) ) -RRB- cord-001397-nrq4ncdf 149 1 † † UH cord-001397-nrq4ncdf 149 2 Miller Miller NNP cord-001397-nrq4ncdf 149 3 et et NNP cord-001397-nrq4ncdf 149 4 al al NNP cord-001397-nrq4ncdf 149 5 . . NNP cord-001397-nrq4ncdf 149 6 , , , cord-001397-nrq4ncdf 149 7 2006 2006 CD cord-001397-nrq4ncdf 149 8 ) ) -RRB- cord-001397-nrq4ncdf 149 9 . . . cord-001397-nrq4ncdf 150 1 NS4B NS4B NNP cord-001397-nrq4ncdf 150 2 appears appear VBZ cord-001397-nrq4ncdf 150 3 also also RB cord-001397-nrq4ncdf 150 4 to to TO cord-001397-nrq4ncdf 150 5 be be VB cord-001397-nrq4ncdf 150 6 involved involve VBN cord-001397-nrq4ncdf 150 7 in in IN cord-001397-nrq4ncdf 150 8 ER ER NNP cord-001397-nrq4ncdf 150 9 rearrangement rearrangement NN cord-001397-nrq4ncdf 150 10 and and CC cord-001397-nrq4ncdf 150 11 modification modification NN cord-001397-nrq4ncdf 150 12 during during IN cord-001397-nrq4ncdf 150 13 viral viral JJ cord-001397-nrq4ncdf 150 14 replication replication NN cord-001397-nrq4ncdf 150 15 ( ( -LRB- cord-001397-nrq4ncdf 150 16 Westaway Westaway NNP cord-001397-nrq4ncdf 150 17 et et NNP cord-001397-nrq4ncdf 150 18 al al NNP cord-001397-nrq4ncdf 150 19 . . NNP cord-001397-nrq4ncdf 150 20 , , , cord-001397-nrq4ncdf 150 21 1997 1997 CD cord-001397-nrq4ncdf 150 22 ) ) -RRB- cord-001397-nrq4ncdf 150 23 . . . cord-001397-nrq4ncdf 151 1 The the DT cord-001397-nrq4ncdf 151 2 NS4B NS4B NNP cord-001397-nrq4ncdf 151 3 protein protein NN cord-001397-nrq4ncdf 151 4 of of IN cord-001397-nrq4ncdf 151 5 WNV WNV NNP cord-001397-nrq4ncdf 151 6 , , , cord-001397-nrq4ncdf 151 7 JEV JEV NNP cord-001397-nrq4ncdf 151 8 , , , cord-001397-nrq4ncdf 151 9 and and CC cord-001397-nrq4ncdf 151 10 DENV DENV NNP cord-001397-nrq4ncdf 151 11 inhibits inhibit VBZ cord-001397-nrq4ncdf 151 12 type type NN cord-001397-nrq4ncdf 152 1 I -PRON- PRP cord-001397-nrq4ncdf 153 1 interferon interferon NNP cord-001397-nrq4ncdf 153 2 ( ( -LRB- cord-001397-nrq4ncdf 153 3 IFN IFN NNP cord-001397-nrq4ncdf 153 4 - - HYPH cord-001397-nrq4ncdf 153 5 a a NNP cord-001397-nrq4ncdf 153 6 / / SYM cord-001397-nrq4ncdf 153 7 b b NN cord-001397-nrq4ncdf 153 8 ) ) -RRB- cord-001397-nrq4ncdf 153 9 response response NN cord-001397-nrq4ncdf 153 10 by by IN cord-001397-nrq4ncdf 153 11 blocking block VBG cord-001397-nrq4ncdf 153 12 the the DT cord-001397-nrq4ncdf 153 13 phosphorylation phosphorylation NN cord-001397-nrq4ncdf 153 14 of of IN cord-001397-nrq4ncdf 153 15 STAT1 stat1 NN cord-001397-nrq4ncdf 154 1 ( ( -LRB- cord-001397-nrq4ncdf 154 2 Muñoz Muñoz NNP cord-001397-nrq4ncdf 154 3 - - HYPH cord-001397-nrq4ncdf 154 4 Jord Jord NNP cord-001397-nrq4ncdf 154 5 an an NNP cord-001397-nrq4ncdf 154 6 et et FW cord-001397-nrq4ncdf 154 7 al al NNP cord-001397-nrq4ncdf 154 8 . . NNP cord-001397-nrq4ncdf 154 9 , , , cord-001397-nrq4ncdf 154 10 2003 2003 CD cord-001397-nrq4ncdf 154 11 , , , cord-001397-nrq4ncdf 154 12 2005 2005 CD cord-001397-nrq4ncdf 155 1 Lin Lin NNP cord-001397-nrq4ncdf 155 2 et et NNP cord-001397-nrq4ncdf 155 3 al al NNP cord-001397-nrq4ncdf 155 4 . . NNP cord-001397-nrq4ncdf 155 5 , , , cord-001397-nrq4ncdf 155 6 2004 2004 CD cord-001397-nrq4ncdf 156 1 ; ; : cord-001397-nrq4ncdf 156 2 Liu Liu NNP cord-001397-nrq4ncdf 156 3 et et NNP cord-001397-nrq4ncdf 156 4 al al NNP cord-001397-nrq4ncdf 156 5 . . NNP cord-001397-nrq4ncdf 156 6 , , , cord-001397-nrq4ncdf 156 7 2005 2005 CD cord-001397-nrq4ncdf 156 8 ; ; : cord-001397-nrq4ncdf 157 1 Evans Evans NNP cord-001397-nrq4ncdf 157 2 & & CC cord-001397-nrq4ncdf 157 3 Seeger Seeger NNP cord-001397-nrq4ncdf 157 4 , , , cord-001397-nrq4ncdf 157 5 2007 2007 CD cord-001397-nrq4ncdf 157 6 ) ) -RRB- cord-001397-nrq4ncdf 157 7 . . . cord-001397-nrq4ncdf 158 1 The the DT cord-001397-nrq4ncdf 158 2 same same JJ cord-001397-nrq4ncdf 158 3 is be VBZ cord-001397-nrq4ncdf 158 4 true true JJ cord-001397-nrq4ncdf 158 5 for for IN cord-001397-nrq4ncdf 158 6 KUNV KUNV NNPS cord-001397-nrq4ncdf 158 7 and and CC cord-001397-nrq4ncdf 158 8 WNV WNV NNP cord-001397-nrq4ncdf 158 9 strain strain VB cord-001397-nrq4ncdf 158 10 NY99 NY99 NNP cord-001397-nrq4ncdf 158 11 , , , cord-001397-nrq4ncdf 158 12 which which WDT cord-001397-nrq4ncdf 158 13 blocks block VBZ cord-001397-nrq4ncdf 158 14 the the DT cord-001397-nrq4ncdf 158 15 activation activation NN cord-001397-nrq4ncdf 158 16 of of IN cord-001397-nrq4ncdf 158 17 STAT1/ STAT1/ NNP cord-001397-nrq4ncdf 158 18 STAT2 STAT2 NNS cord-001397-nrq4ncdf 158 19 and and CC cord-001397-nrq4ncdf 158 20 its -PRON- PRP$ cord-001397-nrq4ncdf 158 21 translocation translocation NN cord-001397-nrq4ncdf 158 22 to to IN cord-001397-nrq4ncdf 158 23 the the DT cord-001397-nrq4ncdf 158 24 nucleus nucleus NN cord-001397-nrq4ncdf 158 25 ( ( -LRB- cord-001397-nrq4ncdf 158 26 Liu Liu NNP cord-001397-nrq4ncdf 158 27 et et NNP cord-001397-nrq4ncdf 158 28 al al NNP cord-001397-nrq4ncdf 158 29 . . NNP cord-001397-nrq4ncdf 158 30 , , , cord-001397-nrq4ncdf 158 31 2005 2005 CD cord-001397-nrq4ncdf 158 32 ) ) -RRB- cord-001397-nrq4ncdf 158 33 . . . cord-001397-nrq4ncdf 159 1 These these DT cord-001397-nrq4ncdf 159 2 events event NNS cord-001397-nrq4ncdf 159 3 disrupt disrupt VBP cord-001397-nrq4ncdf 159 4 the the DT cord-001397-nrq4ncdf 159 5 host host NN cord-001397-nrq4ncdf 159 6 immune immune JJ cord-001397-nrq4ncdf 159 7 responses response NNS cord-001397-nrq4ncdf 159 8 by by IN cord-001397-nrq4ncdf 159 9 blocking block VBG cord-001397-nrq4ncdf 159 10 the the DT cord-001397-nrq4ncdf 159 11 IFNalpha IFNalpha NNS cord-001397-nrq4ncdf 159 12 / / SYM cord-001397-nrq4ncdf 159 13 beta beta NN cord-001397-nrq4ncdf 159 14 / / SYM cord-001397-nrq4ncdf 159 15 gamma gamma JJ cord-001397-nrq4ncdf 159 16 pathways pathway NNS cord-001397-nrq4ncdf 159 17 † † . cord-001397-nrq4ncdf 160 1 NS5 ns5 JJ cord-001397-nrq4ncdf 160 2 7666 7666 CD cord-001397-nrq4ncdf 160 3 - - SYM cord-001397-nrq4ncdf 160 4 10 10 CD cord-001397-nrq4ncdf 160 5 374 374 CD cord-001397-nrq4ncdf 160 6 , , , cord-001397-nrq4ncdf 160 7 100 100 CD cord-001397-nrq4ncdf 160 8 kDa kDa NNS cord-001397-nrq4ncdf 160 9 , , , cord-001397-nrq4ncdf 161 1 900 900 CD cord-001397-nrq4ncdf 161 2 aa aa NNP cord-001397-nrq4ncdf 161 3 Cytosol Cytosol NNP cord-001397-nrq4ncdf 161 4 / / SYM cord-001397-nrq4ncdf 161 5 ER ER NNP cord-001397-nrq4ncdf 161 6 / / SYM cord-001397-nrq4ncdf 161 7 nucleus nucleus NN cord-001397-nrq4ncdf 161 8 NS5 NS5 NNP cord-001397-nrq4ncdf 161 9 is be VBZ cord-001397-nrq4ncdf 161 10 the the DT cord-001397-nrq4ncdf 161 11 largest large JJS cord-001397-nrq4ncdf 161 12 and and CC cord-001397-nrq4ncdf 161 13 most most RBS cord-001397-nrq4ncdf 161 14 conserved conserved JJ cord-001397-nrq4ncdf 161 15 among among IN cord-001397-nrq4ncdf 161 16 the the DT cord-001397-nrq4ncdf 161 17 VBFV VBFV NNP cord-001397-nrq4ncdf 161 18 proteins protein NNS cord-001397-nrq4ncdf 161 19 . . . cord-001397-nrq4ncdf 162 1 NS5 ns5 JJ cord-001397-nrq4ncdf 162 2 primarily primarily RB cord-001397-nrq4ncdf 162 3 functions function NNS cord-001397-nrq4ncdf 162 4 as as IN cord-001397-nrq4ncdf 162 5 the the DT cord-001397-nrq4ncdf 162 6 RNA RNA NNP cord-001397-nrq4ncdf 162 7 - - HYPH cord-001397-nrq4ncdf 162 8 dependent dependent JJ cord-001397-nrq4ncdf 162 9 RNA RNA NNP cord-001397-nrq4ncdf 162 10 polymerase polymerase NN cord-001397-nrq4ncdf 162 11 ( ( -LRB- cord-001397-nrq4ncdf 162 12 RdRp RdRp NNP cord-001397-nrq4ncdf 162 13 ) ) -RRB- cord-001397-nrq4ncdf 162 14 through through IN cord-001397-nrq4ncdf 162 15 its -PRON- PRP$ cord-001397-nrq4ncdf 162 16 C c NN cord-001397-nrq4ncdf 162 17 - - HYPH cord-001397-nrq4ncdf 162 18 terminal terminal NN cord-001397-nrq4ncdf 162 19 domain domain NN cord-001397-nrq4ncdf 162 20 ( ( -LRB- cord-001397-nrq4ncdf 162 21 Lindenbach Lindenbach NNP cord-001397-nrq4ncdf 162 22 et et NNP cord-001397-nrq4ncdf 162 23 al al NNP cord-001397-nrq4ncdf 162 24 . . NNP cord-001397-nrq4ncdf 162 25 , , , cord-001397-nrq4ncdf 162 26 2007 2007 CD cord-001397-nrq4ncdf 162 27 ) ) -RRB- cord-001397-nrq4ncdf 162 28 . . . cord-001397-nrq4ncdf 163 1 The the DT cord-001397-nrq4ncdf 163 2 NS5 NS5 NNP cord-001397-nrq4ncdf 163 3 has have VBZ cord-001397-nrq4ncdf 163 4 been be VBN cord-001397-nrq4ncdf 163 5 crystalized crystalize VBN cord-001397-nrq4ncdf 163 6 and and CC cord-001397-nrq4ncdf 163 7 contains contain VBZ cord-001397-nrq4ncdf 163 8 an an DT cord-001397-nrq4ncdf 163 9 N n CD cord-001397-nrq4ncdf 163 10 - - HYPH cord-001397-nrq4ncdf 163 11 terminal terminal NN cord-001397-nrq4ncdf 163 12 domain domain NN cord-001397-nrq4ncdf 163 13 with with IN cord-001397-nrq4ncdf 163 14 S S NNP cord-001397-nrq4ncdf 163 15 - - HYPH cord-001397-nrq4ncdf 163 16 adenosyl adenosyl NNP cord-001397-nrq4ncdf 163 17 methionine methionine NN cord-001397-nrq4ncdf 163 18 methyltransferase methyltransferase NN cord-001397-nrq4ncdf 163 19 activity activity NN cord-001397-nrq4ncdf 163 20 ( ( -LRB- cord-001397-nrq4ncdf 163 21 MTase MTase NNP cord-001397-nrq4ncdf 163 22 ) ) -RRB- cord-001397-nrq4ncdf 163 23 , , , cord-001397-nrq4ncdf 163 24 and and CC cord-001397-nrq4ncdf 163 25 possibly possibly RB cord-001397-nrq4ncdf 163 26 guanylyltransferase guanylyltransferase NNP cord-001397-nrq4ncdf 163 27 ( ( -LRB- cord-001397-nrq4ncdf 163 28 GTase GTase NNP cord-001397-nrq4ncdf 163 29 ) ) -RRB- cord-001397-nrq4ncdf 163 30 for for IN cord-001397-nrq4ncdf 163 31 RNA RNA NNP cord-001397-nrq4ncdf 163 32 capping capping NN cord-001397-nrq4ncdf 164 1 ( ( -LRB- cord-001397-nrq4ncdf 164 2 Egloff Egloff NNP cord-001397-nrq4ncdf 164 3 et et FW cord-001397-nrq4ncdf 164 4 al al NNP cord-001397-nrq4ncdf 164 5 . . . cord-001397-nrq4ncdf 165 1 , , , cord-001397-nrq4ncdf 165 2 2002 2002 CD cord-001397-nrq4ncdf 165 3 ; ; : cord-001397-nrq4ncdf 165 4 Malet Malet NNP cord-001397-nrq4ncdf 165 5 et et NNP cord-001397-nrq4ncdf 165 6 al al NNP cord-001397-nrq4ncdf 165 7 . . NNP cord-001397-nrq4ncdf 165 8 , , , cord-001397-nrq4ncdf 165 9 2007 2007 CD cord-001397-nrq4ncdf 166 1 ; ; : cord-001397-nrq4ncdf 166 2 Yap Yap NNP cord-001397-nrq4ncdf 166 3 et et NNP cord-001397-nrq4ncdf 166 4 al al NNP cord-001397-nrq4ncdf 166 5 . . NNP cord-001397-nrq4ncdf 166 6 , , , cord-001397-nrq4ncdf 166 7 2007 2007 CD cord-001397-nrq4ncdf 166 8 ) ) -RRB- cord-001397-nrq4ncdf 166 9 . . . cord-001397-nrq4ncdf 167 1 NS5 NS5 NNP cord-001397-nrq4ncdf 167 2 is be VBZ cord-001397-nrq4ncdf 167 3 also also RB cord-001397-nrq4ncdf 167 4 involved involve VBN cord-001397-nrq4ncdf 167 5 in in IN cord-001397-nrq4ncdf 167 6 activating activate VBG cord-001397-nrq4ncdf 167 7 other other JJ cord-001397-nrq4ncdf 167 8 viral viral JJ cord-001397-nrq4ncdf 167 9 proteins protein NNS cord-001397-nrq4ncdf 167 10 , , , cord-001397-nrq4ncdf 167 11 such such JJ cord-001397-nrq4ncdf 167 12 as as IN cord-001397-nrq4ncdf 167 13 NS3 NS3 NNP cord-001397-nrq4ncdf 167 14 NTPase NTPase NNP cord-001397-nrq4ncdf 167 15 and and CC cord-001397-nrq4ncdf 167 16 RTPase RTPase NNP cord-001397-nrq4ncdf 167 17 activity activity NN cord-001397-nrq4ncdf 167 18 in in IN cord-001397-nrq4ncdf 167 19 a a DT cord-001397-nrq4ncdf 167 20 dose dose NN cord-001397-nrq4ncdf 167 21 - - HYPH cord-001397-nrq4ncdf 167 22 dependent dependent JJ cord-001397-nrq4ncdf 167 23 manner manner NN cord-001397-nrq4ncdf 167 24 . . . cord-001397-nrq4ncdf 168 1 DENV DENV NNP cord-001397-nrq4ncdf 168 2 NS5 NS5 NNP cord-001397-nrq4ncdf 168 3 contains contain VBZ cord-001397-nrq4ncdf 168 4 both both DT cord-001397-nrq4ncdf 168 5 nuclear nuclear JJ cord-001397-nrq4ncdf 168 6 localization localization NN cord-001397-nrq4ncdf 168 7 signal signal NN cord-001397-nrq4ncdf 168 8 ( ( -LRB- cord-001397-nrq4ncdf 168 9 NLS NLS NNP cord-001397-nrq4ncdf 168 10 ) ) -RRB- cord-001397-nrq4ncdf 168 11 and and CC cord-001397-nrq4ncdf 168 12 nuclear nuclear JJ cord-001397-nrq4ncdf 168 13 export export NN cord-001397-nrq4ncdf 168 14 signal signal NN cord-001397-nrq4ncdf 168 15 ( ( -LRB- cord-001397-nrq4ncdf 168 16 NES NES NNP cord-001397-nrq4ncdf 168 17 ) ) -RRB- cord-001397-nrq4ncdf 168 18 : : : cord-001397-nrq4ncdf 169 1 These these DT cord-001397-nrq4ncdf 169 2 facilitate facilitate VBP cord-001397-nrq4ncdf 169 3 its -PRON- PRP$ cord-001397-nrq4ncdf 169 4 importation importation NN cord-001397-nrq4ncdf 169 5 into into IN cord-001397-nrq4ncdf 169 6 the the DT cord-001397-nrq4ncdf 169 7 nucleus nucleus NN cord-001397-nrq4ncdf 169 8 by by IN cord-001397-nrq4ncdf 169 9 both both DT cord-001397-nrq4ncdf 169 10 importin importin NN cord-001397-nrq4ncdf 169 11 b1 b1 NN cord-001397-nrq4ncdf 169 12 and and CC cord-001397-nrq4ncdf 169 13 the the DT cord-001397-nrq4ncdf 169 14 importin importin NNP cord-001397-nrq4ncdf 169 15 a a NNP cord-001397-nrq4ncdf 169 16 / / SYM cord-001397-nrq4ncdf 169 17 b b NN cord-001397-nrq4ncdf 169 18 complex complex NN cord-001397-nrq4ncdf 169 19 , , , cord-001397-nrq4ncdf 169 20 and and CC cord-001397-nrq4ncdf 169 21 an an DT cord-001397-nrq4ncdf 169 22 additional additional JJ cord-001397-nrq4ncdf 169 23 function function NN cord-001397-nrq4ncdf 169 24 of of IN cord-001397-nrq4ncdf 169 25 the the DT cord-001397-nrq4ncdf 169 26 signals signal NNS cord-001397-nrq4ncdf 169 27 could could MD cord-001397-nrq4ncdf 169 28 be be VB cord-001397-nrq4ncdf 169 29 enhancement enhancement NN cord-001397-nrq4ncdf 169 30 of of IN cord-001397-nrq4ncdf 169 31 virus virus NN cord-001397-nrq4ncdf 169 32 replication replication NN cord-001397-nrq4ncdf 169 33 and and CC cord-001397-nrq4ncdf 169 34 hyperphosphorylation hyperphosphorylation NN cord-001397-nrq4ncdf 169 35 of of IN cord-001397-nrq4ncdf 169 36 NS5 ns5 JJ cord-001397-nrq4ncdf 169 37 ( ( -LRB- cord-001397-nrq4ncdf 169 38 Johansson Johansson NNP cord-001397-nrq4ncdf 169 39 et et NNP cord-001397-nrq4ncdf 169 40 al al NNP cord-001397-nrq4ncdf 169 41 . . NNP cord-001397-nrq4ncdf 169 42 , , , cord-001397-nrq4ncdf 169 43 2001 2001 CD cord-001397-nrq4ncdf 169 44 ; ; : cord-001397-nrq4ncdf 169 45 Brooks Brooks NNP cord-001397-nrq4ncdf 169 46 et et NNP cord-001397-nrq4ncdf 169 47 al al NNP cord-001397-nrq4ncdf 169 48 . . NNP cord-001397-nrq4ncdf 169 49 , , , cord-001397-nrq4ncdf 169 50 2002 2002 CD cord-001397-nrq4ncdf 169 51 ) ) -RRB- cord-001397-nrq4ncdf 169 52 . . . cord-001397-nrq4ncdf 170 1 For for IN cord-001397-nrq4ncdf 170 2 WNV WNV NNP cord-001397-nrq4ncdf 170 3 , , , cord-001397-nrq4ncdf 170 4 NS5 NS5 NNP cord-001397-nrq4ncdf 170 5 is be VBZ cord-001397-nrq4ncdf 170 6 exported export VBN cord-001397-nrq4ncdf 170 7 from from IN cord-001397-nrq4ncdf 170 8 the the DT cord-001397-nrq4ncdf 170 9 nucleus nucleus NN cord-001397-nrq4ncdf 170 10 in in IN cord-001397-nrq4ncdf 170 11 a a DT cord-001397-nrq4ncdf 170 12 chromosome chromosome NN cord-001397-nrq4ncdf 170 13 region region NN cord-001397-nrq4ncdf 170 14 maintenance maintenance NN cord-001397-nrq4ncdf 170 15 1 1 CD cord-001397-nrq4ncdf 170 16 ( ( -LRB- cord-001397-nrq4ncdf 170 17 CRM1)-dependent crm1)-dependent CD cord-001397-nrq4ncdf 170 18 manner manner NN cord-001397-nrq4ncdf 170 19 ( ( -LRB- cord-001397-nrq4ncdf 170 20 Pryor Pryor NNP cord-001397-nrq4ncdf 170 21 et et NNP cord-001397-nrq4ncdf 170 22 al al NNP cord-001397-nrq4ncdf 170 23 . . NNP cord-001397-nrq4ncdf 170 24 , , , cord-001397-nrq4ncdf 170 25 2007 2007 CD cord-001397-nrq4ncdf 170 26 ; ; : cord-001397-nrq4ncdf 170 27 Rawlinson Rawlinson NNP cord-001397-nrq4ncdf 170 28 et et NNP cord-001397-nrq4ncdf 170 29 al al NNP cord-001397-nrq4ncdf 170 30 . . NNP cord-001397-nrq4ncdf 170 31 , , , cord-001397-nrq4ncdf 170 32 2009 2009 CD cord-001397-nrq4ncdf 170 33 ) ) -RRB- cord-001397-nrq4ncdf 170 34 . . . cord-001397-nrq4ncdf 171 1 NS5 NS5 NNP cord-001397-nrq4ncdf 171 2 is be VBZ cord-001397-nrq4ncdf 171 3 involved involve VBN cord-001397-nrq4ncdf 171 4 in in IN cord-001397-nrq4ncdf 171 5 different different JJ cord-001397-nrq4ncdf 171 6 cellular cellular JJ cord-001397-nrq4ncdf 171 7 pathways pathway NNS cord-001397-nrq4ncdf 171 8 and and CC cord-001397-nrq4ncdf 171 9 has have VBZ cord-001397-nrq4ncdf 171 10 a a DT cord-001397-nrq4ncdf 171 11 crucial crucial JJ cord-001397-nrq4ncdf 171 12 role role NN cord-001397-nrq4ncdf 171 13 in in IN cord-001397-nrq4ncdf 171 14 the the DT cord-001397-nrq4ncdf 171 15 escape escape NN cord-001397-nrq4ncdf 171 16 from from IN cord-001397-nrq4ncdf 171 17 , , , cord-001397-nrq4ncdf 171 18 or or CC cord-001397-nrq4ncdf 171 19 blocking blocking NN cord-001397-nrq4ncdf 171 20 , , , cord-001397-nrq4ncdf 171 21 the the DT cord-001397-nrq4ncdf 171 22 interferonalpha interferonalpha NNP cord-001397-nrq4ncdf 171 23 / / SYM cord-001397-nrq4ncdf 171 24 beta beta NN cord-001397-nrq4ncdf 171 25 ( ( -LRB- cord-001397-nrq4ncdf 171 26 IFN IFN NNP cord-001397-nrq4ncdf 171 27 - - HYPH cord-001397-nrq4ncdf 171 28 alpha alpha NN cord-001397-nrq4ncdf 171 29 / / SYM cord-001397-nrq4ncdf 171 30 beta beta NN cord-001397-nrq4ncdf 171 31 ) ) -RRB- cord-001397-nrq4ncdf 171 32 signaling signal VBG cord-001397-nrq4ncdf 171 33 pathway pathway NN cord-001397-nrq4ncdf 171 34 . . . cord-001397-nrq4ncdf 172 1 DENV DENV NNP cord-001397-nrq4ncdf 172 2 NS5 NS5 NNP cord-001397-nrq4ncdf 172 3 inhibits inhibit VBZ cord-001397-nrq4ncdf 172 4 host host NN cord-001397-nrq4ncdf 172 5 TYK2 TYK2 NNP cord-001397-nrq4ncdf 172 6 and and CC cord-001397-nrq4ncdf 172 7 STAT2 STAT2 NNS cord-001397-nrq4ncdf 172 8 phosphorylation phosphorylation NN cord-001397-nrq4ncdf 172 9 and and CC cord-001397-nrq4ncdf 172 10 prevents prevent VBZ cord-001397-nrq4ncdf 172 11 the the DT cord-001397-nrq4ncdf 172 12 activation activation NN cord-001397-nrq4ncdf 172 13 of of IN cord-001397-nrq4ncdf 172 14 JAK JAK NNP cord-001397-nrq4ncdf 172 15 - - HYPH cord-001397-nrq4ncdf 172 16 STAT STAT NNP cord-001397-nrq4ncdf 172 17 signaling signal VBG cord-001397-nrq4ncdf 172 18 pathway pathway NN cord-001397-nrq4ncdf 172 19 ( ( -LRB- cord-001397-nrq4ncdf 172 20 Mazzon Mazzon NNP cord-001397-nrq4ncdf 172 21 et et NNP cord-001397-nrq4ncdf 172 22 al al NNP cord-001397-nrq4ncdf 172 23 . . NNP cord-001397-nrq4ncdf 172 24 , , , cord-001397-nrq4ncdf 172 25 2009 2009 CD cord-001397-nrq4ncdf 172 26 ) ) -RRB- cord-001397-nrq4ncdf 173 1 In in IN cord-001397-nrq4ncdf 173 2 addition addition NN cord-001397-nrq4ncdf 173 3 to to IN cord-001397-nrq4ncdf 173 4 the the DT cord-001397-nrq4ncdf 173 5 viral viral JJ cord-001397-nrq4ncdf 173 6 RdRp RdRp NNP cord-001397-nrq4ncdf 173 7 functions function NNS cord-001397-nrq4ncdf 173 8 of of IN cord-001397-nrq4ncdf 173 9 NS5 NS5 NNP cord-001397-nrq4ncdf 173 10 described describe VBN cord-001397-nrq4ncdf 173 11 for for IN cord-001397-nrq4ncdf 173 12 the the DT cord-001397-nrq4ncdf 173 13 MBFVs mbfv NNS cord-001397-nrq4ncdf 173 14 , , , cord-001397-nrq4ncdf 173 15 the the DT cord-001397-nrq4ncdf 173 16 TBFV TBFV NNP cord-001397-nrq4ncdf 173 17 NS5 NS5 NNP cord-001397-nrq4ncdf 173 18 was be VBD cord-001397-nrq4ncdf 173 19 the the DT cord-001397-nrq4ncdf 173 20 first first JJ cord-001397-nrq4ncdf 173 21 to to TO cord-001397-nrq4ncdf 173 22 be be VB cord-001397-nrq4ncdf 173 23 implicated implicate VBN cord-001397-nrq4ncdf 173 24 in in IN cord-001397-nrq4ncdf 173 25 disrupting disrupt VBG cord-001397-nrq4ncdf 173 26 innate innate JJ cord-001397-nrq4ncdf 173 27 immune immune JJ cord-001397-nrq4ncdf 173 28 signaling signaling NN cord-001397-nrq4ncdf 173 29 . . . cord-001397-nrq4ncdf 174 1 To to TO cord-001397-nrq4ncdf 174 2 suppress suppress VB cord-001397-nrq4ncdf 174 3 critical critical JJ cord-001397-nrq4ncdf 174 4 host host NN cord-001397-nrq4ncdf 174 5 responses response NNS cord-001397-nrq4ncdf 174 6 , , , cord-001397-nrq4ncdf 174 7 LGTV LGTV NNP cord-001397-nrq4ncdf 174 8 NS5 NS5 NNP cord-001397-nrq4ncdf 174 9 interacts interact VBZ cord-001397-nrq4ncdf 174 10 with with IN cord-001397-nrq4ncdf 174 11 IFNAR2 IFNAR2 NNS cord-001397-nrq4ncdf 174 12 and and CC cord-001397-nrq4ncdf 174 13 IFNGR2 ifngr2 XX cord-001397-nrq4ncdf 174 14 , , , cord-001397-nrq4ncdf 174 15 two two CD cord-001397-nrq4ncdf 174 16 IFN IFN NNP cord-001397-nrq4ncdf 174 17 receptor receptor NN cord-001397-nrq4ncdf 174 18 subunits subunit NNS cord-001397-nrq4ncdf 174 19 , , , cord-001397-nrq4ncdf 174 20 and and CC cord-001397-nrq4ncdf 174 21 antagonizes antagonize VBZ cord-001397-nrq4ncdf 174 22 IFNdependent ifndependent NN cord-001397-nrq4ncdf 174 23 responses response NNS cord-001397-nrq4ncdf 174 24 by by IN cord-001397-nrq4ncdf 174 25 suppressing suppress VBG cord-001397-nrq4ncdf 174 26 JAK JAK NNP cord-001397-nrq4ncdf 174 27 - - HYPH cord-001397-nrq4ncdf 174 28 STAT stat NN cord-001397-nrq4ncdf 174 29 signal signal NN cord-001397-nrq4ncdf 174 30 transduction transduction NN cord-001397-nrq4ncdf 174 31 ( ( -LRB- cord-001397-nrq4ncdf 174 32 Best best RB cord-001397-nrq4ncdf 174 33 et et FW cord-001397-nrq4ncdf 174 34 al al NNP cord-001397-nrq4ncdf 174 35 . . NNP cord-001397-nrq4ncdf 174 36 , , , cord-001397-nrq4ncdf 174 37 2005 2005 CD cord-001397-nrq4ncdf 174 38 ; ; : cord-001397-nrq4ncdf 174 39 Park Park NNP cord-001397-nrq4ncdf 174 40 et et FW cord-001397-nrq4ncdf 174 41 al al NNP cord-001397-nrq4ncdf 174 42 . . NNP cord-001397-nrq4ncdf 174 43 , , , cord-001397-nrq4ncdf 174 44 2007 2007 CD cord-001397-nrq4ncdf 174 45 ) ) -RRB- cord-001397-nrq4ncdf 174 46 . . . cord-001397-nrq4ncdf 175 1 Cellular cellular JJ cord-001397-nrq4ncdf 175 2 responses response NNS cord-001397-nrq4ncdf 175 3 targeted target VBN cord-001397-nrq4ncdf 175 4 at at IN cord-001397-nrq4ncdf 175 5 restricting restrict VBG cord-001397-nrq4ncdf 175 6 viral viral JJ cord-001397-nrq4ncdf 175 7 replication replication NN cord-001397-nrq4ncdf 175 8 occur occur VBP cord-001397-nrq4ncdf 175 9 via via IN cord-001397-nrq4ncdf 175 10 lysosomal lysosomal JJ cord-001397-nrq4ncdf 175 11 degradation degradation NN cord-001397-nrq4ncdf 175 12 of of IN cord-001397-nrq4ncdf 175 13 NS5 NS5 NNP cord-001397-nrq4ncdf 175 14 , , , cord-001397-nrq4ncdf 175 15 NS2B NS2B NNP cord-001397-nrq4ncdf 175 16 , , , cord-001397-nrq4ncdf 175 17 and and CC cord-001397-nrq4ncdf 175 18 NS3 ns3 RB cord-001397-nrq4ncdf 175 19 . . . cord-001397-nrq4ncdf 176 1 The the DT cord-001397-nrq4ncdf 176 2 NS5 ns5 JJ cord-001397-nrq4ncdf 176 3 of of IN cord-001397-nrq4ncdf 176 4 LGTV LGTV NNP cord-001397-nrq4ncdf 176 5 and and CC cord-001397-nrq4ncdf 176 6 TBEV TBEV NNP cord-001397-nrq4ncdf 176 7 interacts interact VBZ cord-001397-nrq4ncdf 176 8 with with IN cord-001397-nrq4ncdf 176 9 TRIM79-alpha TRIM79-alpha NNP cord-001397-nrq4ncdf 176 10 , , , cord-001397-nrq4ncdf 176 11 an an DT cord-001397-nrq4ncdf 176 12 IFN IFN NNP cord-001397-nrq4ncdf 176 13 - - HYPH cord-001397-nrq4ncdf 176 14 inducible inducible JJ cord-001397-nrq4ncdf 176 15 protein protein NN cord-001397-nrq4ncdf 176 16 , , , cord-001397-nrq4ncdf 176 17 and and CC cord-001397-nrq4ncdf 176 18 induces induce VBZ cord-001397-nrq4ncdf 176 19 the the DT cord-001397-nrq4ncdf 176 20 degradation degradation NN cord-001397-nrq4ncdf 176 21 ( ( -LRB- cord-001397-nrq4ncdf 176 22 Taylor Taylor NNP cord-001397-nrq4ncdf 176 23 et et NNP cord-001397-nrq4ncdf 176 24 al al NNP cord-001397-nrq4ncdf 176 25 . . NNP cord-001397-nrq4ncdf 176 26 , , , cord-001397-nrq4ncdf 176 27 2011 2011 CD cord-001397-nrq4ncdf 176 28 ) ) -RRB- cord-001397-nrq4ncdf 176 29 . . . cord-001397-nrq4ncdf 177 1 The the DT cord-001397-nrq4ncdf 177 2 cellular cellular JJ cord-001397-nrq4ncdf 177 3 antiviral antiviral JJ cord-001397-nrq4ncdf 177 4 state state NN cord-001397-nrq4ncdf 177 5 is be VBZ cord-001397-nrq4ncdf 177 6 also also RB cord-001397-nrq4ncdf 177 7 compromised compromise VBN cord-001397-nrq4ncdf 177 8 by by IN cord-001397-nrq4ncdf 177 9 TBEV TBEV NNP cord-001397-nrq4ncdf 177 10 NS5 ns5 JJ cord-001397-nrq4ncdf 177 11 interaction interaction NN cord-001397-nrq4ncdf 177 12 with with IN cord-001397-nrq4ncdf 177 13 the the DT cord-001397-nrq4ncdf 177 14 scaffold scaffold NN cord-001397-nrq4ncdf 177 15 protein protein NN cord-001397-nrq4ncdf 177 16 Scribble Scribble NNP cord-001397-nrq4ncdf 178 1 ( ( -LRB- cord-001397-nrq4ncdf 178 2 Werme Werme NNP cord-001397-nrq4ncdf 178 3 et et NNP cord-001397-nrq4ncdf 178 4 al al NNP cord-001397-nrq4ncdf 178 5 . . NNP cord-001397-nrq4ncdf 178 6 , , , cord-001397-nrq4ncdf 178 7 2008 2008 CD cord-001397-nrq4ncdf 178 8 ) ) -RRB- cord-001397-nrq4ncdf 178 9 . . . cord-001397-nrq4ncdf 179 1 This this DT cord-001397-nrq4ncdf 179 2 complex complex JJ cord-001397-nrq4ncdf 179 3 blocks block VBZ cord-001397-nrq4ncdf 179 4 the the DT cord-001397-nrq4ncdf 179 5 phosphorylation phosphorylation NN cord-001397-nrq4ncdf 179 6 of of IN cord-001397-nrq4ncdf 179 7 STAT1 stat1 NN cord-001397-nrq4ncdf 179 8 and and CC cord-001397-nrq4ncdf 179 9 disrupts disrupt VBZ cord-001397-nrq4ncdf 179 10 the the DT cord-001397-nrq4ncdf 179 11 JAK JAK NNP cord-001397-nrq4ncdf 179 12 - - HYPH cord-001397-nrq4ncdf 179 13 STAT STAT NNP cord-001397-nrq4ncdf 179 14 signaling signal VBG cord-001397-nrq4ncdf 179 15 pathway pathway NN cord-001397-nrq4ncdf 180 1 The the DT cord-001397-nrq4ncdf 180 2 extreme extreme JJ cord-001397-nrq4ncdf 180 3 3 3 CD cord-001397-nrq4ncdf 180 4 0 0 CD cord-001397-nrq4ncdf 180 5 terminal terminal NN cord-001397-nrq4ncdf 180 6 region region NN cord-001397-nrq4ncdf 180 7 contains contain VBZ cord-001397-nrq4ncdf 180 8 secondary secondary JJ cord-001397-nrq4ncdf 180 9 structures structure NNS cord-001397-nrq4ncdf 180 10 and and CC cord-001397-nrq4ncdf 180 11 RNA RNA NNP cord-001397-nrq4ncdf 180 12 elements element NNS cord-001397-nrq4ncdf 180 13 important important JJ cord-001397-nrq4ncdf 180 14 for for IN cord-001397-nrq4ncdf 180 15 cyclization cyclization NN cord-001397-nrq4ncdf 180 16 of of IN cord-001397-nrq4ncdf 180 17 the the DT cord-001397-nrq4ncdf 180 18 genome genome NN cord-001397-nrq4ncdf 180 19 and and CC cord-001397-nrq4ncdf 180 20 virus virus NN cord-001397-nrq4ncdf 180 21 viability viability NN cord-001397-nrq4ncdf 180 22 . . . cord-001397-nrq4ncdf 181 1 The the DT cord-001397-nrq4ncdf 181 2 MBFV MBFV NNP cord-001397-nrq4ncdf 181 3 3 3 CD cord-001397-nrq4ncdf 181 4 0 0 CD cord-001397-nrq4ncdf 181 5 UTR UTR NNP cord-001397-nrq4ncdf 181 6 can can MD cord-001397-nrq4ncdf 181 7 be be VB cord-001397-nrq4ncdf 181 8 divided divide VBN cord-001397-nrq4ncdf 181 9 into into IN cord-001397-nrq4ncdf 181 10 three three CD cord-001397-nrq4ncdf 181 11 regions region NNS cord-001397-nrq4ncdf 181 12 ( ( -LRB- cord-001397-nrq4ncdf 181 13 Markoff Markoff NNP cord-001397-nrq4ncdf 181 14 , , , cord-001397-nrq4ncdf 181 15 2003 2003 CD cord-001397-nrq4ncdf 181 16 ; ; : cord-001397-nrq4ncdf 181 17 Liu Liu NNP cord-001397-nrq4ncdf 181 18 et et NNP cord-001397-nrq4ncdf 181 19 al al NNP cord-001397-nrq4ncdf 181 20 . . NNP cord-001397-nrq4ncdf 181 21 , , , cord-001397-nrq4ncdf 181 22 2009 2009 CD cord-001397-nrq4ncdf 181 23 ): ): NN cord-001397-nrq4ncdf 181 24 a a DT cord-001397-nrq4ncdf 181 25 variable variable JJ cord-001397-nrq4ncdf 181 26 region region NN cord-001397-nrq4ncdf 181 27 directly directly RB cord-001397-nrq4ncdf 181 28 upstream upstream RB cord-001397-nrq4ncdf 181 29 of of IN cord-001397-nrq4ncdf 181 30 the the DT cord-001397-nrq4ncdf 181 31 stop stop NN cord-001397-nrq4ncdf 181 32 codon codon NN cord-001397-nrq4ncdf 181 33 ; ; : cord-001397-nrq4ncdf 181 34 a a DT cord-001397-nrq4ncdf 181 35 second second JJ cord-001397-nrq4ncdf 181 36 region region NN cord-001397-nrq4ncdf 181 37 that that WDT cord-001397-nrq4ncdf 181 38 is be VBZ cord-001397-nrq4ncdf 181 39 relatively relatively RB cord-001397-nrq4ncdf 181 40 conserved conserve VBN cord-001397-nrq4ncdf 181 41 in in IN cord-001397-nrq4ncdf 181 42 nucleotide nucleotide JJ cord-001397-nrq4ncdf 181 43 sequences sequence NNS cord-001397-nrq4ncdf 181 44 containing contain VBG cord-001397-nrq4ncdf 181 45 hairpin hairpin NN cord-001397-nrq4ncdf 181 46 motifs motif NNS cord-001397-nrq4ncdf 181 47 ; ; : cord-001397-nrq4ncdf 181 48 and and CC cord-001397-nrq4ncdf 182 1 a a DT cord-001397-nrq4ncdf 182 2 highly highly RB cord-001397-nrq4ncdf 182 3 conserved conserve VBN cord-001397-nrq4ncdf 182 4 core core NN cord-001397-nrq4ncdf 182 5 element element NN cord-001397-nrq4ncdf 182 6 contains contain VBZ cord-001397-nrq4ncdf 182 7 stable stable JJ cord-001397-nrq4ncdf 182 8 SL sl NN cord-001397-nrq4ncdf 182 9 structures structure NNS cord-001397-nrq4ncdf 182 10 and and CC cord-001397-nrq4ncdf 182 11 cyclization cyclization NN cord-001397-nrq4ncdf 182 12 motif motif NN cord-001397-nrq4ncdf 182 13 ( ( -LRB- cord-001397-nrq4ncdf 182 14 Villordo Villordo NNP cord-001397-nrq4ncdf 182 15 & & CC cord-001397-nrq4ncdf 182 16 Gamarnik Gamarnik NNP cord-001397-nrq4ncdf 182 17 , , , cord-001397-nrq4ncdf 182 18 2009 2009 CD cord-001397-nrq4ncdf 182 19 ) ) -RRB- cord-001397-nrq4ncdf 183 1 The the DT cord-001397-nrq4ncdf 183 2 3 3 CD cord-001397-nrq4ncdf 183 3 0 0 CD cord-001397-nrq4ncdf 183 4 UTR UTR NNP cord-001397-nrq4ncdf 183 5 of of IN cord-001397-nrq4ncdf 183 6 TBFVs tbfvs JJ cord-001397-nrq4ncdf 183 7 exhibits exhibit VBZ cord-001397-nrq4ncdf 183 8 significant significant JJ cord-001397-nrq4ncdf 183 9 heterogeneity heterogeneity NN cord-001397-nrq4ncdf 183 10 in in IN cord-001397-nrq4ncdf 183 11 length length NN cord-001397-nrq4ncdf 183 12 and and CC cord-001397-nrq4ncdf 183 13 sequence sequence NN cord-001397-nrq4ncdf 183 14 even even RB cord-001397-nrq4ncdf 183 15 among among IN cord-001397-nrq4ncdf 183 16 closely closely RB cord-001397-nrq4ncdf 183 17 related related JJ cord-001397-nrq4ncdf 183 18 strains strain NNS cord-001397-nrq4ncdf 183 19 . . . cord-001397-nrq4ncdf 184 1 The the DT cord-001397-nrq4ncdf 184 2 TBFV TBFV NNP cord-001397-nrq4ncdf 184 3 3 3 CD cord-001397-nrq4ncdf 184 4 0 0 CD cord-001397-nrq4ncdf 184 5 UTR UTR NNP cord-001397-nrq4ncdf 184 6 can can MD cord-001397-nrq4ncdf 184 7 also also RB cord-001397-nrq4ncdf 184 8 be be VB cord-001397-nrq4ncdf 184 9 divided divide VBN cord-001397-nrq4ncdf 184 10 into into IN cord-001397-nrq4ncdf 184 11 a a DT cord-001397-nrq4ncdf 184 12 variable variable JJ cord-001397-nrq4ncdf 184 13 region region NN cord-001397-nrq4ncdf 184 14 part part NN cord-001397-nrq4ncdf 184 15 and and CC cord-001397-nrq4ncdf 184 16 an an DT cord-001397-nrq4ncdf 184 17 extremely extremely RB cord-001397-nrq4ncdf 184 18 conserved conserved JJ cord-001397-nrq4ncdf 184 19 core core NN cord-001397-nrq4ncdf 184 20 element element NN cord-001397-nrq4ncdf 184 21 ( ( -LRB- cord-001397-nrq4ncdf 185 1 Gritsun Gritsun NNP cord-001397-nrq4ncdf 185 2 et et NNP cord-001397-nrq4ncdf 185 3 al al NNP cord-001397-nrq4ncdf 185 4 . . . cord-001397-nrq4ncdf 186 1 , , , cord-001397-nrq4ncdf 186 2 1997 1997 CD cord-001397-nrq4ncdf 186 3 ) ) -RRB- cord-001397-nrq4ncdf 186 4 , , , cord-001397-nrq4ncdf 186 5 where where WRB cord-001397-nrq4ncdf 186 6 the the DT cord-001397-nrq4ncdf 186 7 length length NN cord-001397-nrq4ncdf 186 8 variability variability NN cord-001397-nrq4ncdf 186 9 of of IN cord-001397-nrq4ncdf 186 10 the the DT cord-001397-nrq4ncdf 186 11 variable variable JJ cord-001397-nrq4ncdf 186 12 region region NN cord-001397-nrq4ncdf 186 13 has have VBZ cord-001397-nrq4ncdf 186 14 been be VBN cord-001397-nrq4ncdf 186 15 suggested suggest VBN cord-001397-nrq4ncdf 186 16 to to TO cord-001397-nrq4ncdf 186 17 be be VB cord-001397-nrq4ncdf 186 18 related relate VBN cord-001397-nrq4ncdf 186 19 to to IN cord-001397-nrq4ncdf 186 20 the the DT cord-001397-nrq4ncdf 186 21 number number NN cord-001397-nrq4ncdf 186 22 of of IN cord-001397-nrq4ncdf 186 23 laboratory laboratory NN cord-001397-nrq4ncdf 186 24 passages passage NNS cord-001397-nrq4ncdf 186 25 ( ( -LRB- cord-001397-nrq4ncdf 186 26 Mandl Mandl NNP cord-001397-nrq4ncdf 186 27 et et NNP cord-001397-nrq4ncdf 186 28 al al NNP cord-001397-nrq4ncdf 186 29 . . . cord-001397-nrq4ncdf 187 1 , , , cord-001397-nrq4ncdf 187 2 1998 1998 CD cord-001397-nrq4ncdf 187 3 ; ; : cord-001397-nrq4ncdf 187 4 Mandl Mandl NNP cord-001397-nrq4ncdf 187 5 , , , cord-001397-nrq4ncdf 187 6 2005 2005 CD cord-001397-nrq4ncdf 187 7 ) ) -RRB- cord-001397-nrq4ncdf 187 8 . . . cord-001397-nrq4ncdf 188 1 A a DT cord-001397-nrq4ncdf 188 2 hypothesis hypothesis NN cord-001397-nrq4ncdf 188 3 interprets interpret VBZ cord-001397-nrq4ncdf 188 4 the the DT cord-001397-nrq4ncdf 188 5 biological biological JJ cord-001397-nrq4ncdf 188 6 importance importance NN cord-001397-nrq4ncdf 188 7 of of IN cord-001397-nrq4ncdf 188 8 the the DT cord-001397-nrq4ncdf 188 9 variable variable JJ cord-001397-nrq4ncdf 188 10 region region NN cord-001397-nrq4ncdf 188 11 that that WDT cord-001397-nrq4ncdf 188 12 influences influence VBZ cord-001397-nrq4ncdf 188 13 the the DT cord-001397-nrq4ncdf 188 14 replication replication NN cord-001397-nrq4ncdf 188 15 / / SYM cord-001397-nrq4ncdf 188 16 translation translation NN cord-001397-nrq4ncdf 188 17 dynamics dynamic NNS cord-001397-nrq4ncdf 188 18 in in IN cord-001397-nrq4ncdf 188 19 mammalian mammalian JJ cord-001397-nrq4ncdf 188 20 and and CC cord-001397-nrq4ncdf 188 21 tick tick NN cord-001397-nrq4ncdf 188 22 cells cell NNS cord-001397-nrq4ncdf 188 23 ( ( -LRB- cord-001397-nrq4ncdf 188 24 Elvang Elvang NNP cord-001397-nrq4ncdf 188 25 et et FW cord-001397-nrq4ncdf 188 26 al al NNP cord-001397-nrq4ncdf 188 27 . . NNP cord-001397-nrq4ncdf 188 28 , , , cord-001397-nrq4ncdf 188 29 2011 2011 CD cord-001397-nrq4ncdf 188 30 ) ) -RRB- cord-001397-nrq4ncdf 188 31 . . . cord-001397-nrq4ncdf 189 1 The the DT cord-001397-nrq4ncdf 189 2 conserved conserve VBN cord-001397-nrq4ncdf 189 3 core core NN cord-001397-nrq4ncdf 189 4 element element NN cord-001397-nrq4ncdf 189 5 contains contain VBZ cord-001397-nrq4ncdf 189 6 highly highly RB cord-001397-nrq4ncdf 189 7 essential essential JJ cord-001397-nrq4ncdf 189 8 sequential sequential JJ cord-001397-nrq4ncdf 189 9 and and CC cord-001397-nrq4ncdf 189 10 structural structural JJ cord-001397-nrq4ncdf 189 11 motifs motif NNS cord-001397-nrq4ncdf 189 12 defined define VBN cord-001397-nrq4ncdf 189 13 as as IN cord-001397-nrq4ncdf 189 14 SL1 SL1 NNP cord-001397-nrq4ncdf 189 15 - - HYPH cord-001397-nrq4ncdf 189 16 5 5 CD cord-001397-nrq4ncdf 189 17 for for IN cord-001397-nrq4ncdf 189 18 viral viral JJ cord-001397-nrq4ncdf 189 19 maintenance maintenance NN cord-001397-nrq4ncdf 190 1 ( ( -LRB- cord-001397-nrq4ncdf 190 2 Mandl Mandl NNP cord-001397-nrq4ncdf 190 3 et et NNP cord-001397-nrq4ncdf 190 4 al al NNP cord-001397-nrq4ncdf 190 5 . . NNP cord-001397-nrq4ncdf 190 6 , , , cord-001397-nrq4ncdf 190 7 1998 1998 CD cord-001397-nrq4ncdf 190 8 ; ; : cord-001397-nrq4ncdf 190 9 Pletnev Pletnev NNP cord-001397-nrq4ncdf 190 10 , , , cord-001397-nrq4ncdf 190 11 2001 2001 CD cord-001397-nrq4ncdf 190 12 ) ) -RRB- cord-001397-nrq4ncdf 190 13 . . . cord-001397-nrq4ncdf 191 1 The the DT cord-001397-nrq4ncdf 191 2 pentanucleotide pentanucleotide NN cord-001397-nrq4ncdf 191 3 ( ( -LRB- cord-001397-nrq4ncdf 191 4 GAGAG GAGAG NNP cord-001397-nrq4ncdf 191 5 ) ) -RRB- cord-001397-nrq4ncdf 191 6 motif motif NN cord-001397-nrq4ncdf 191 7 exposed expose VBN cord-001397-nrq4ncdf 191 8 on on IN cord-001397-nrq4ncdf 191 9 the the DT cord-001397-nrq4ncdf 191 10 SL4 sl4 NN cord-001397-nrq4ncdf 191 11 is be VBZ cord-001397-nrq4ncdf 191 12 strictly strictly RB cord-001397-nrq4ncdf 191 13 conserved conserve VBN cord-001397-nrq4ncdf 191 14 among among IN cord-001397-nrq4ncdf 191 15 all all PDT cord-001397-nrq4ncdf 191 16 the the DT cord-001397-nrq4ncdf 191 17 flavivirus flavivirus JJ cord-001397-nrq4ncdf 191 18 genomes genome NNS cord-001397-nrq4ncdf 191 19 . . . cord-001397-nrq4ncdf 192 1 Other other JJ cord-001397-nrq4ncdf 192 2 important important JJ cord-001397-nrq4ncdf 192 3 elements element NNS cord-001397-nrq4ncdf 192 4 present present JJ cord-001397-nrq4ncdf 192 5 in in IN cord-001397-nrq4ncdf 192 6 the the DT cord-001397-nrq4ncdf 192 7 conserved conserve VBN cord-001397-nrq4ncdf 192 8 region region NN cord-001397-nrq4ncdf 192 9 include include VBP cord-001397-nrq4ncdf 192 10 the the DT cord-001397-nrq4ncdf 192 11 homopurine homopurine NNP cord-001397-nrq4ncdf 192 12 box box NNP cord-001397-nrq4ncdf 192 13 , , , cord-001397-nrq4ncdf 192 14 a a DT cord-001397-nrq4ncdf 192 15 homopyrimidine homopyrimidine NN cord-001397-nrq4ncdf 192 16 box box NN cord-001397-nrq4ncdf 192 17 , , , cord-001397-nrq4ncdf 192 18 and and CC cord-001397-nrq4ncdf 192 19 cyclization cyclization NN cord-001397-nrq4ncdf 192 20 sequences sequence NNS cord-001397-nrq4ncdf 192 21 ( ( -LRB- cord-001397-nrq4ncdf 192 22 Mandl Mandl NNP cord-001397-nrq4ncdf 192 23 , , , cord-001397-nrq4ncdf 192 24 2005 2005 CD cord-001397-nrq4ncdf 192 25 ; ; : cord-001397-nrq4ncdf 192 26 Gritsun Gritsun NNP cord-001397-nrq4ncdf 192 27 & & CC cord-001397-nrq4ncdf 192 28 Gould Gould NNP cord-001397-nrq4ncdf 192 29 , , , cord-001397-nrq4ncdf 192 30 2007a 2007a CD cord-001397-nrq4ncdf 192 31 , , , cord-001397-nrq4ncdf 192 32 b b LS cord-001397-nrq4ncdf 192 33 ) ) -RRB- cord-001397-nrq4ncdf 193 1 * * NFP cord-001397-nrq4ncdf 193 2 Nucleotide nucleotide JJ cord-001397-nrq4ncdf 193 3 numbers number NNS cord-001397-nrq4ncdf 193 4 are be VBP cord-001397-nrq4ncdf 193 5 related relate VBN cord-001397-nrq4ncdf 193 6 to to IN cord-001397-nrq4ncdf 193 7 the the DT cord-001397-nrq4ncdf 193 8 strain strain NN cord-001397-nrq4ncdf 193 9 Neudoerfl Neudoerfl NNP cord-001397-nrq4ncdf 193 10 of of IN cord-001397-nrq4ncdf 193 11 TBEV TBEV NNP cord-001397-nrq4ncdf 193 12 . . . cord-001397-nrq4ncdf 194 1 † † FW cord-001397-nrq4ncdf 194 2 Shared share VBN cord-001397-nrq4ncdf 194 3 function function NN cord-001397-nrq4ncdf 194 4 is be VBZ cord-001397-nrq4ncdf 194 5 presumed presume VBN cord-001397-nrq4ncdf 194 6 for for IN cord-001397-nrq4ncdf 194 7 both both DT cord-001397-nrq4ncdf 194 8 mosquito mosquito NN cord-001397-nrq4ncdf 194 9 - - HYPH cord-001397-nrq4ncdf 194 10 and and CC cord-001397-nrq4ncdf 194 11 tick tick VB cord-001397-nrq4ncdf 194 12 - - HYPH cord-001397-nrq4ncdf 194 13 borne bear VBN cord-001397-nrq4ncdf 194 14 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 194 15 . . . cord-001397-nrq4ncdf 195 1 In in IN cord-001397-nrq4ncdf 195 2 many many JJ cord-001397-nrq4ncdf 195 3 cases case NNS cord-001397-nrq4ncdf 195 4 , , , cord-001397-nrq4ncdf 195 5 no no DT cord-001397-nrq4ncdf 195 6 specific specific JJ cord-001397-nrq4ncdf 195 7 studies study NNS cord-001397-nrq4ncdf 195 8 have have VBP cord-001397-nrq4ncdf 195 9 been be VBN cord-001397-nrq4ncdf 195 10 carried carry VBN cord-001397-nrq4ncdf 195 11 out out RP cord-001397-nrq4ncdf 195 12 in in IN cord-001397-nrq4ncdf 195 13 TBFV TBFV NNP cord-001397-nrq4ncdf 195 14 . . . cord-001397-nrq4ncdf 196 1 brane brane NNP cord-001397-nrq4ncdf 196 2 ( ( -LRB- cord-001397-nrq4ncdf 196 3 prM prM NNP cord-001397-nrq4ncdf 196 4 / / SYM cord-001397-nrq4ncdf 196 5 M M NNP cord-001397-nrq4ncdf 196 6 ) ) -RRB- cord-001397-nrq4ncdf 196 7 , , , cord-001397-nrq4ncdf 196 8 and and CC cord-001397-nrq4ncdf 196 9 envelope envelope NN cord-001397-nrq4ncdf 196 10 ( ( -LRB- cord-001397-nrq4ncdf 196 11 E E NNP cord-001397-nrq4ncdf 196 12 ) ) -RRB- cord-001397-nrq4ncdf 196 13 , , , cord-001397-nrq4ncdf 196 14 and and CC cord-001397-nrq4ncdf 196 15 seven seven CD cord-001397-nrq4ncdf 196 16 nonstructural nonstructural JJ cord-001397-nrq4ncdf 196 17 proteins protein NNS cord-001397-nrq4ncdf 196 18 : : : cord-001397-nrq4ncdf 196 19 NS1 ns1 UH cord-001397-nrq4ncdf 196 20 , , , cord-001397-nrq4ncdf 196 21 NS2A ns2a UH cord-001397-nrq4ncdf 196 22 , , , cord-001397-nrq4ncdf 196 23 NS2B NS2B NNP cord-001397-nrq4ncdf 196 24 , , , cord-001397-nrq4ncdf 196 25 NS3 ns3 RB cord-001397-nrq4ncdf 196 26 , , , cord-001397-nrq4ncdf 196 27 NS4A NS4A NNP cord-001397-nrq4ncdf 196 28 , , , cord-001397-nrq4ncdf 196 29 NS4B NS4B NNP cord-001397-nrq4ncdf 196 30 , , , cord-001397-nrq4ncdf 196 31 and and CC cord-001397-nrq4ncdf 196 32 NS5 ns5 JJ cord-001397-nrq4ncdf 196 33 ( ( -LRB- cord-001397-nrq4ncdf 196 34 Chambers Chambers NNP cord-001397-nrq4ncdf 196 35 et et NNP cord-001397-nrq4ncdf 196 36 al al NNP cord-001397-nrq4ncdf 196 37 . . NNP cord-001397-nrq4ncdf 196 38 , , , cord-001397-nrq4ncdf 196 39 1990 1990 CD cord-001397-nrq4ncdf 196 40 ; ; : cord-001397-nrq4ncdf 196 41 Ryan Ryan NNP cord-001397-nrq4ncdf 196 42 et et NNP cord-001397-nrq4ncdf 196 43 al al NNP cord-001397-nrq4ncdf 196 44 . . NNP cord-001397-nrq4ncdf 196 45 , , , cord-001397-nrq4ncdf 196 46 1998 1998 CD cord-001397-nrq4ncdf 196 47 ; ; : cord-001397-nrq4ncdf 196 48 Bollati Bollati NNP cord-001397-nrq4ncdf 196 49 et et NNP cord-001397-nrq4ncdf 196 50 al al NNP cord-001397-nrq4ncdf 196 51 . . NNP cord-001397-nrq4ncdf 196 52 , , , cord-001397-nrq4ncdf 196 53 2010 2010 CD cord-001397-nrq4ncdf 196 54 ) ) -RRB- cord-001397-nrq4ncdf 196 55 . . . cord-001397-nrq4ncdf 197 1 The the DT cord-001397-nrq4ncdf 197 2 defined define VBN cord-001397-nrq4ncdf 197 3 functions function NNS cord-001397-nrq4ncdf 197 4 of of IN cord-001397-nrq4ncdf 197 5 these these DT cord-001397-nrq4ncdf 197 6 proteins protein NNS cord-001397-nrq4ncdf 197 7 are be VBP cord-001397-nrq4ncdf 197 8 presented present VBN cord-001397-nrq4ncdf 197 9 in in IN cord-001397-nrq4ncdf 197 10 Table Table NNP cord-001397-nrq4ncdf 197 11 1 1 CD cord-001397-nrq4ncdf 197 12 . . . cord-001397-nrq4ncdf 198 1 However however RB cord-001397-nrq4ncdf 198 2 , , , cord-001397-nrq4ncdf 198 3 the the DT cord-001397-nrq4ncdf 198 4 precise precise JJ cord-001397-nrq4ncdf 198 5 function function NN cord-001397-nrq4ncdf 198 6 of of IN cord-001397-nrq4ncdf 198 7 some some DT cord-001397-nrq4ncdf 198 8 of of IN cord-001397-nrq4ncdf 198 9 the the DT cord-001397-nrq4ncdf 198 10 proteins protein NNS cord-001397-nrq4ncdf 198 11 remains remain VBZ cord-001397-nrq4ncdf 198 12 to to TO cord-001397-nrq4ncdf 198 13 be be VB cord-001397-nrq4ncdf 198 14 elucidated elucidate VBN cord-001397-nrq4ncdf 198 15 . . . cord-001397-nrq4ncdf 199 1 Furthermore furthermore RB cord-001397-nrq4ncdf 199 2 , , , cord-001397-nrq4ncdf 199 3 it -PRON- PRP cord-001397-nrq4ncdf 199 4 should should MD cord-001397-nrq4ncdf 199 5 be be VB cord-001397-nrq4ncdf 199 6 noted note VBN cord-001397-nrq4ncdf 199 7 that that IN cord-001397-nrq4ncdf 199 8 the the DT cord-001397-nrq4ncdf 199 9 bulk bulk NN cord-001397-nrq4ncdf 199 10 of of IN cord-001397-nrq4ncdf 199 11 the the DT cord-001397-nrq4ncdf 199 12 studies study NNS cord-001397-nrq4ncdf 199 13 have have VBP cord-001397-nrq4ncdf 199 14 been be VBN cord-001397-nrq4ncdf 199 15 carried carry VBN cord-001397-nrq4ncdf 199 16 out out RP cord-001397-nrq4ncdf 199 17 in in IN cord-001397-nrq4ncdf 199 18 MBFV MBFV NNP cord-001397-nrq4ncdf 199 19 systems system NNS cord-001397-nrq4ncdf 199 20 , , , cord-001397-nrq4ncdf 199 21 and and CC cord-001397-nrq4ncdf 199 22 it -PRON- PRP cord-001397-nrq4ncdf 199 23 is be VBZ cord-001397-nrq4ncdf 199 24 possible possible JJ cord-001397-nrq4ncdf 199 25 that that IN cord-001397-nrq4ncdf 199 26 the the DT cord-001397-nrq4ncdf 199 27 functions function NNS cord-001397-nrq4ncdf 199 28 may may MD cord-001397-nrq4ncdf 199 29 not not RB cord-001397-nrq4ncdf 199 30 be be VB cord-001397-nrq4ncdf 199 31 identical identical JJ cord-001397-nrq4ncdf 199 32 in in IN cord-001397-nrq4ncdf 199 33 TBFV TBFV NNP cord-001397-nrq4ncdf 199 34 . . . cord-001397-nrq4ncdf 200 1 Recognizing recognize VBG cord-001397-nrq4ncdf 200 2 that that IN cord-001397-nrq4ncdf 200 3 the the DT cord-001397-nrq4ncdf 200 4 VBFVs vbfvs JJ cord-001397-nrq4ncdf 200 5 cycle cycle NN cord-001397-nrq4ncdf 200 6 between between IN cord-001397-nrq4ncdf 200 7 vertebrate vertebrate NN cord-001397-nrq4ncdf 200 8 and and CC cord-001397-nrq4ncdf 200 9 arthropod arthropod NN cord-001397-nrq4ncdf 200 10 hosts host NNS cord-001397-nrq4ncdf 200 11 and and CC cord-001397-nrq4ncdf 200 12 that that IN cord-001397-nrq4ncdf 200 13 both both CC cord-001397-nrq4ncdf 200 14 viral viral JJ cord-001397-nrq4ncdf 200 15 and and CC cord-001397-nrq4ncdf 200 16 host host NN cord-001397-nrq4ncdf 200 17 factors factor NNS cord-001397-nrq4ncdf 200 18 are be VBP cord-001397-nrq4ncdf 200 19 likely likely JJ cord-001397-nrq4ncdf 200 20 to to TO cord-001397-nrq4ncdf 200 21 be be VB cord-001397-nrq4ncdf 200 22 involved involve VBN cord-001397-nrq4ncdf 200 23 , , , cord-001397-nrq4ncdf 200 24 it -PRON- PRP cord-001397-nrq4ncdf 200 25 is be VBZ cord-001397-nrq4ncdf 200 26 highly highly RB cord-001397-nrq4ncdf 200 27 probable probable JJ cord-001397-nrq4ncdf 200 28 that that IN cord-001397-nrq4ncdf 200 29 viral viral JJ cord-001397-nrq4ncdf 200 30 persistence persistence NN cord-001397-nrq4ncdf 200 31 is be VBZ cord-001397-nrq4ncdf 200 32 exceedingly exceedingly RB cord-001397-nrq4ncdf 200 33 complex complex JJ cord-001397-nrq4ncdf 200 34 . . . cord-001397-nrq4ncdf 201 1 The the DT cord-001397-nrq4ncdf 201 2 purpose purpose NN cord-001397-nrq4ncdf 201 3 of of IN cord-001397-nrq4ncdf 201 4 this this DT cord-001397-nrq4ncdf 201 5 review review NN cord-001397-nrq4ncdf 201 6 is be VBZ cord-001397-nrq4ncdf 201 7 to to TO cord-001397-nrq4ncdf 201 8 evaluate evaluate VB cord-001397-nrq4ncdf 201 9 the the DT cord-001397-nrq4ncdf 201 10 current current JJ cord-001397-nrq4ncdf 201 11 literature literature NN cord-001397-nrq4ncdf 201 12 on on IN cord-001397-nrq4ncdf 201 13 flavivirus flavivirus JJ cord-001397-nrq4ncdf 201 14 persistence persistence NN cord-001397-nrq4ncdf 201 15 as as RB cord-001397-nrq4ncdf 201 16 well well RB cord-001397-nrq4ncdf 201 17 as as IN cord-001397-nrq4ncdf 201 18 to to TO cord-001397-nrq4ncdf 201 19 suggest suggest VB cord-001397-nrq4ncdf 201 20 ideas idea NNS cord-001397-nrq4ncdf 201 21 for for IN cord-001397-nrq4ncdf 201 22 additional additional JJ cord-001397-nrq4ncdf 201 23 research research NN cord-001397-nrq4ncdf 201 24 into into IN cord-001397-nrq4ncdf 201 25 this this DT cord-001397-nrq4ncdf 201 26 interesting interesting JJ cord-001397-nrq4ncdf 201 27 and and CC cord-001397-nrq4ncdf 201 28 important important JJ cord-001397-nrq4ncdf 201 29 area area NN cord-001397-nrq4ncdf 201 30 . . . cord-001397-nrq4ncdf 202 1 Humans human NNS cord-001397-nrq4ncdf 202 2 are be VBP cord-001397-nrq4ncdf 202 3 inadvertent inadvertent JJ cord-001397-nrq4ncdf 202 4 targets target NNS cord-001397-nrq4ncdf 202 5 of of IN cord-001397-nrq4ncdf 202 6 VBFV vbfv NN cord-001397-nrq4ncdf 202 7 infection infection NN cord-001397-nrq4ncdf 202 8 ( ( -LRB- cord-001397-nrq4ncdf 202 9 Figs Figs NNP cord-001397-nrq4ncdf 202 10 1 1 CD cord-001397-nrq4ncdf 202 11 and and CC cord-001397-nrq4ncdf 202 12 2 2 CD cord-001397-nrq4ncdf 202 13 ) ) -RRB- cord-001397-nrq4ncdf 202 14 , , , cord-001397-nrq4ncdf 202 15 and and CC cord-001397-nrq4ncdf 202 16 infection infection NN cord-001397-nrq4ncdf 202 17 is be VBZ cord-001397-nrq4ncdf 202 18 often often RB cord-001397-nrq4ncdf 202 19 associated associate VBN cord-001397-nrq4ncdf 202 20 with with IN cord-001397-nrq4ncdf 202 21 debilitating debilitating JJ cord-001397-nrq4ncdf 202 22 , , , cord-001397-nrq4ncdf 202 23 acute acute JJ cord-001397-nrq4ncdf 202 24 neurological neurological JJ cord-001397-nrq4ncdf 202 25 syndromes syndrome NNS cord-001397-nrq4ncdf 202 26 or or CC cord-001397-nrq4ncdf 202 27 hemorrhagic hemorrhagic JJ cord-001397-nrq4ncdf 202 28 fever fever NN cord-001397-nrq4ncdf 202 29 . . . cord-001397-nrq4ncdf 203 1 However however RB cord-001397-nrq4ncdf 203 2 , , , cord-001397-nrq4ncdf 203 3 there there EX cord-001397-nrq4ncdf 203 4 are be VBP cord-001397-nrq4ncdf 203 5 several several JJ cord-001397-nrq4ncdf 203 6 lines line NNS cord-001397-nrq4ncdf 203 7 of of IN cord-001397-nrq4ncdf 203 8 evidence evidence NN cord-001397-nrq4ncdf 203 9 suggesting suggest VBG cord-001397-nrq4ncdf 203 10 flavivirus flavivirus JJ cord-001397-nrq4ncdf 203 11 persistence persistence NN cord-001397-nrq4ncdf 203 12 in in IN cord-001397-nrq4ncdf 203 13 humans human NNS cord-001397-nrq4ncdf 203 14 ( ( -LRB- cord-001397-nrq4ncdf 203 15 Murray Murray NNP cord-001397-nrq4ncdf 203 16 et et NNP cord-001397-nrq4ncdf 203 17 al al NNP cord-001397-nrq4ncdf 203 18 . . NNP cord-001397-nrq4ncdf 203 19 , , , cord-001397-nrq4ncdf 203 20 2010 2010 CD cord-001397-nrq4ncdf 203 21 ; ; : cord-001397-nrq4ncdf 203 22 Gibney Gibney NNP cord-001397-nrq4ncdf 203 23 et et NNP cord-001397-nrq4ncdf 203 24 al al NNP cord-001397-nrq4ncdf 203 25 . . NNP cord-001397-nrq4ncdf 203 26 , , , cord-001397-nrq4ncdf 203 27 2011 2011 CD cord-001397-nrq4ncdf 203 28 ; ; : cord-001397-nrq4ncdf 203 29 Baty Baty NNP cord-001397-nrq4ncdf 203 30 et et NNP cord-001397-nrq4ncdf 203 31 al al NNP cord-001397-nrq4ncdf 203 32 . . NNP cord-001397-nrq4ncdf 203 33 , , , cord-001397-nrq4ncdf 203 34 2012 2012 CD cord-001397-nrq4ncdf 203 35 ) ) -RRB- cord-001397-nrq4ncdf 203 36 . . . cord-001397-nrq4ncdf 204 1 The the DT cord-001397-nrq4ncdf 204 2 establishment establishment NN cord-001397-nrq4ncdf 204 3 of of IN cord-001397-nrq4ncdf 204 4 flavivirus flavivirus JJ cord-001397-nrq4ncdf 204 5 persistence persistence NN cord-001397-nrq4ncdf 204 6 in in IN cord-001397-nrq4ncdf 204 7 humans human NNS cord-001397-nrq4ncdf 204 8 seems seem VBZ cord-001397-nrq4ncdf 204 9 to to TO cord-001397-nrq4ncdf 204 10 be be VB cord-001397-nrq4ncdf 204 11 mainly mainly RB cord-001397-nrq4ncdf 204 12 associated associate VBN cord-001397-nrq4ncdf 204 13 with with IN cord-001397-nrq4ncdf 204 14 encephalitic encephalitic JJ cord-001397-nrq4ncdf 204 15 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 204 16 ( ( -LRB- cord-001397-nrq4ncdf 204 17 Diamond Diamond NNP cord-001397-nrq4ncdf 204 18 , , , cord-001397-nrq4ncdf 204 19 2003 2003 CD cord-001397-nrq4ncdf 204 20 ) ) -RRB- cord-001397-nrq4ncdf 204 21 . . . cord-001397-nrq4ncdf 205 1 However however RB cord-001397-nrq4ncdf 205 2 , , , cord-001397-nrq4ncdf 205 3 YFV YFV NNP cord-001397-nrq4ncdf 205 4 and and CC cord-001397-nrq4ncdf 205 5 DENV DENV NNP cord-001397-nrq4ncdf 205 6 persistence persistence NN cord-001397-nrq4ncdf 205 7 has have VBZ cord-001397-nrq4ncdf 205 8 been be VBN cord-001397-nrq4ncdf 205 9 described describe VBN cord-001397-nrq4ncdf 205 10 in in IN cord-001397-nrq4ncdf 205 11 eukaryotic eukaryotic JJ cord-001397-nrq4ncdf 205 12 cells cell NNS cord-001397-nrq4ncdf 205 13 in in IN cord-001397-nrq4ncdf 205 14 culture culture NN cord-001397-nrq4ncdf 205 15 and and CC cord-001397-nrq4ncdf 205 16 in in IN cord-001397-nrq4ncdf 205 17 successive successive JJ cord-001397-nrq4ncdf 205 18 generations generation NNS cord-001397-nrq4ncdf 205 19 of of IN cord-001397-nrq4ncdf 205 20 Aedes Aedes NNP cord-001397-nrq4ncdf 205 21 mosquitoes mosquito NNS cord-001397-nrq4ncdf 205 22 ( ( -LRB- cord-001397-nrq4ncdf 205 23 Lodge Lodge NNP cord-001397-nrq4ncdf 205 24 et et NNP cord-001397-nrq4ncdf 205 25 al al NNP cord-001397-nrq4ncdf 205 26 . . NNP cord-001397-nrq4ncdf 205 27 , , , cord-001397-nrq4ncdf 205 28 1987 1987 CD cord-001397-nrq4ncdf 205 29 ; ; : cord-001397-nrq4ncdf 205 30 Takasaki Takasaki NNP cord-001397-nrq4ncdf 205 31 et et NNP cord-001397-nrq4ncdf 205 32 al al NNP cord-001397-nrq4ncdf 205 33 . . NNP cord-001397-nrq4ncdf 205 34 , , , cord-001397-nrq4ncdf 205 35 2001 2001 CD cord-001397-nrq4ncdf 205 36 ; ; : cord-001397-nrq4ncdf 205 37 Farfan Farfan NNP cord-001397-nrq4ncdf 205 38 - - HYPH cord-001397-nrq4ncdf 205 39 Ale Ale NNP cord-001397-nrq4ncdf 205 40 et et FW cord-001397-nrq4ncdf 205 41 al al NNP cord-001397-nrq4ncdf 205 42 . . NNP cord-001397-nrq4ncdf 205 43 , , , cord-001397-nrq4ncdf 205 44 2009 2009 CD cord-001397-nrq4ncdf 205 45 ) ) -RRB- cord-001397-nrq4ncdf 205 46 . . . cord-001397-nrq4ncdf 206 1 YFV YFV NNP cord-001397-nrq4ncdf 206 2 and and CC cord-001397-nrq4ncdf 206 3 DENV DENV NNP cord-001397-nrq4ncdf 206 4 commonly commonly RB cord-001397-nrq4ncdf 206 5 cause cause VBP cord-001397-nrq4ncdf 206 6 a a DT cord-001397-nrq4ncdf 206 7 hemorrhagic hemorrhagic JJ cord-001397-nrq4ncdf 206 8 illness illness NN cord-001397-nrq4ncdf 206 9 , , , cord-001397-nrq4ncdf 206 10 jaundice jaundice NN cord-001397-nrq4ncdf 206 11 , , , cord-001397-nrq4ncdf 206 12 and and CC cord-001397-nrq4ncdf 206 13 dengue dengue NN cord-001397-nrq4ncdf 206 14 shock shock NN cord-001397-nrq4ncdf 206 15 syndrome syndrome NN cord-001397-nrq4ncdf 206 16 , , , cord-001397-nrq4ncdf 206 17 and and CC cord-001397-nrq4ncdf 206 18 encephalitis encephalitis NN cord-001397-nrq4ncdf 206 19 is be VBZ cord-001397-nrq4ncdf 206 20 atypical atypical JJ cord-001397-nrq4ncdf 206 21 and and CC cord-001397-nrq4ncdf 206 22 extremely extremely RB cord-001397-nrq4ncdf 206 23 rare rare JJ cord-001397-nrq4ncdf 206 24 , , , cord-001397-nrq4ncdf 206 25 and and CC cord-001397-nrq4ncdf 206 26 delivered deliver VBN cord-001397-nrq4ncdf 206 27 to to IN cord-001397-nrq4ncdf 206 28 endosomes endosome NNS cord-001397-nrq4ncdf 206 29 , , , cord-001397-nrq4ncdf 206 30 where where WRB cord-001397-nrq4ncdf 206 31 a a DT cord-001397-nrq4ncdf 206 32 pH ph JJ cord-001397-nrq4ncdf 206 33 - - HYPH cord-001397-nrq4ncdf 206 34 dependent dependent JJ cord-001397-nrq4ncdf 206 35 fusion fusion NN cord-001397-nrq4ncdf 206 36 of of IN cord-001397-nrq4ncdf 206 37 the the DT cord-001397-nrq4ncdf 206 38 particles particle NNS cord-001397-nrq4ncdf 206 39 with with IN cord-001397-nrq4ncdf 206 40 the the DT cord-001397-nrq4ncdf 206 41 endosome endosome NN cord-001397-nrq4ncdf 206 42 membrane membrane NN cord-001397-nrq4ncdf 206 43 occurs occur VBZ cord-001397-nrq4ncdf 206 44 ( ( -LRB- cord-001397-nrq4ncdf 206 45 c c NN cord-001397-nrq4ncdf 206 46 ) ) -RRB- cord-001397-nrq4ncdf 206 47 . . . cord-001397-nrq4ncdf 207 1 Subsequent subsequent JJ cord-001397-nrq4ncdf 207 2 to to IN cord-001397-nrq4ncdf 207 3 uncoating uncoating NN cord-001397-nrq4ncdf 207 4 , , , cord-001397-nrq4ncdf 207 5 the the DT cord-001397-nrq4ncdf 207 6 single single RB cord-001397-nrq4ncdf 207 7 - - HYPH cord-001397-nrq4ncdf 207 8 stranded stranded JJ cord-001397-nrq4ncdf 207 9 , , , cord-001397-nrq4ncdf 207 10 positive positive JJ cord-001397-nrq4ncdf 207 11 - - HYPH cord-001397-nrq4ncdf 207 12 sense sense NN cord-001397-nrq4ncdf 207 13 RNA RNA NNP cord-001397-nrq4ncdf 207 14 genome genome NN cord-001397-nrq4ncdf 207 15 ( ( -LRB- cord-001397-nrq4ncdf 207 16 d d NN cord-001397-nrq4ncdf 207 17 ) ) -RRB- cord-001397-nrq4ncdf 207 18 migrates migrate VBZ cord-001397-nrq4ncdf 207 19 to to IN cord-001397-nrq4ncdf 207 20 the the DT cord-001397-nrq4ncdf 207 21 endoplasmic endoplasmic NN cord-001397-nrq4ncdf 207 22 reticulum reticulum NN cord-001397-nrq4ncdf 207 23 ( ( -LRB- cord-001397-nrq4ncdf 207 24 ER ER NNP cord-001397-nrq4ncdf 207 25 ) ) -RRB- cord-001397-nrq4ncdf 207 26 and and CC cord-001397-nrq4ncdf 207 27 is be VBZ cord-001397-nrq4ncdf 207 28 translated translate VBN cord-001397-nrq4ncdf 207 29 ( ( -LRB- cord-001397-nrq4ncdf 207 30 e e LS cord-001397-nrq4ncdf 207 31 ) ) -RRB- cord-001397-nrq4ncdf 207 32 as as IN cord-001397-nrq4ncdf 207 33 a a DT cord-001397-nrq4ncdf 207 34 polyprotein polyprotein NN cord-001397-nrq4ncdf 207 35 traversing traverse VBG cord-001397-nrq4ncdf 207 36 the the DT cord-001397-nrq4ncdf 207 37 ER ER NNP cord-001397-nrq4ncdf 207 38 membrane membrane NN cord-001397-nrq4ncdf 207 39 several several JJ cord-001397-nrq4ncdf 207 40 times time NNS cord-001397-nrq4ncdf 207 41 ( ( -LRB- cord-001397-nrq4ncdf 207 42 f f NNP cord-001397-nrq4ncdf 207 43 ) ) -RRB- cord-001397-nrq4ncdf 207 44 . . . cord-001397-nrq4ncdf 208 1 The the DT cord-001397-nrq4ncdf 208 2 polyprotein polyprotein NN cord-001397-nrq4ncdf 208 3 is be VBZ cord-001397-nrq4ncdf 208 4 cleaved cleave VBN cord-001397-nrq4ncdf 208 5 into into IN cord-001397-nrq4ncdf 208 6 the the DT cord-001397-nrq4ncdf 208 7 viral viral JJ cord-001397-nrq4ncdf 208 8 proteins protein NNS cord-001397-nrq4ncdf 208 9 by by IN cord-001397-nrq4ncdf 208 10 viral viral JJ cord-001397-nrq4ncdf 208 11 and and CC cord-001397-nrq4ncdf 208 12 cellular cellular JJ cord-001397-nrq4ncdf 208 13 proteases protease NNS cord-001397-nrq4ncdf 208 14 , , , cord-001397-nrq4ncdf 208 15 although although IN cord-001397-nrq4ncdf 208 16 prM prm JJ cord-001397-nrq4ncdf 208 17 and and CC cord-001397-nrq4ncdf 208 18 E E NNS cord-001397-nrq4ncdf 208 19 remain remain VBP cord-001397-nrq4ncdf 208 20 covalently covalently RB cord-001397-nrq4ncdf 208 21 attached attach VBN cord-001397-nrq4ncdf 208 22 . . . cord-001397-nrq4ncdf 209 1 Through through IN cord-001397-nrq4ncdf 209 2 the the DT cord-001397-nrq4ncdf 209 3 agency agency NN cord-001397-nrq4ncdf 209 4 of of IN cord-001397-nrq4ncdf 209 5 several several JJ cord-001397-nrq4ncdf 209 6 viral viral JJ cord-001397-nrq4ncdf 209 7 nonstructural nonstructural JJ cord-001397-nrq4ncdf 209 8 proteins protein NNS cord-001397-nrq4ncdf 209 9 and and CC cord-001397-nrq4ncdf 209 10 cellular cellular JJ cord-001397-nrq4ncdf 209 11 proteins protein NNS cord-001397-nrq4ncdf 209 12 , , , cord-001397-nrq4ncdf 209 13 there there EX cord-001397-nrq4ncdf 209 14 is be VBZ cord-001397-nrq4ncdf 209 15 a a DT cord-001397-nrq4ncdf 209 16 proliferation proliferation NN cord-001397-nrq4ncdf 209 17 of of IN cord-001397-nrq4ncdf 209 18 ER er NN cord-001397-nrq4ncdf 209 19 - - HYPH cord-001397-nrq4ncdf 209 20 derived derive VBN cord-001397-nrq4ncdf 209 21 membranes membrane NNS cord-001397-nrq4ncdf 209 22 and and CC cord-001397-nrq4ncdf 209 23 the the DT cord-001397-nrq4ncdf 209 24 formation formation NN cord-001397-nrq4ncdf 209 25 of of IN cord-001397-nrq4ncdf 209 26 spherules spherule NNS cord-001397-nrq4ncdf 209 27 that that WDT cord-001397-nrq4ncdf 209 28 maintain maintain VBP cord-001397-nrq4ncdf 209 29 a a DT cord-001397-nrq4ncdf 209 30 pore pore NN cord-001397-nrq4ncdf 209 31 - - HYPH cord-001397-nrq4ncdf 209 32 like like JJ cord-001397-nrq4ncdf 209 33 connection connection NN cord-001397-nrq4ncdf 209 34 to to IN cord-001397-nrq4ncdf 209 35 the the DT cord-001397-nrq4ncdf 209 36 cytoplasm cytoplasm NN cord-001397-nrq4ncdf 209 37 ( ( -LRB- cord-001397-nrq4ncdf 209 38 g g NN cord-001397-nrq4ncdf 209 39 ) ) -RRB- cord-001397-nrq4ncdf 209 40 ; ; : cord-001397-nrq4ncdf 209 41 the the DT cord-001397-nrq4ncdf 209 42 viral viral JJ cord-001397-nrq4ncdf 209 43 genome genome NN cord-001397-nrq4ncdf 209 44 is be VBZ cord-001397-nrq4ncdf 209 45 replicated replicate VBN cord-001397-nrq4ncdf 209 46 within within IN cord-001397-nrq4ncdf 209 47 these these DT cord-001397-nrq4ncdf 209 48 spherules spherule NNS cord-001397-nrq4ncdf 209 49 by by IN cord-001397-nrq4ncdf 209 50 the the DT cord-001397-nrq4ncdf 209 51 viral viral JJ cord-001397-nrq4ncdf 209 52 proteins protein NNS cord-001397-nrq4ncdf 209 53 comprising comprise VBG cord-001397-nrq4ncdf 209 54 the the DT cord-001397-nrq4ncdf 209 55 replication replication NN cord-001397-nrq4ncdf 209 56 complex complex NN cord-001397-nrq4ncdf 209 57 . . . cord-001397-nrq4ncdf 210 1 By by IN cord-001397-nrq4ncdf 210 2 an an DT cord-001397-nrq4ncdf 210 3 as as RB cord-001397-nrq4ncdf 210 4 yet yet RB cord-001397-nrq4ncdf 210 5 uncharacterized uncharacterized JJ cord-001397-nrq4ncdf 210 6 mechanism mechanism NN cord-001397-nrq4ncdf 210 7 , , , cord-001397-nrq4ncdf 210 8 progeny progeny NN cord-001397-nrq4ncdf 210 9 genomes genome NNS cord-001397-nrq4ncdf 210 10 are be VBP cord-001397-nrq4ncdf 210 11 delivered deliver VBN cord-001397-nrq4ncdf 210 12 to to IN cord-001397-nrq4ncdf 210 13 adjacent adjacent JJ cord-001397-nrq4ncdf 210 14 ER ER NNP cord-001397-nrq4ncdf 210 15 membranes membrane NNS cord-001397-nrq4ncdf 210 16 where where WRB cord-001397-nrq4ncdf 210 17 the the DT cord-001397-nrq4ncdf 210 18 capsid capsid JJ cord-001397-nrq4ncdf 210 19 protein protein NN cord-001397-nrq4ncdf 210 20 mediates mediate VBZ cord-001397-nrq4ncdf 210 21 assembly assembly NN cord-001397-nrq4ncdf 210 22 and and CC cord-001397-nrq4ncdf 210 23 inclusion inclusion NN cord-001397-nrq4ncdf 210 24 of of IN cord-001397-nrq4ncdf 210 25 prM prm JJ cord-001397-nrq4ncdf 210 26 - - HYPH cord-001397-nrq4ncdf 210 27 E e NN cord-001397-nrq4ncdf 210 28 into into IN cord-001397-nrq4ncdf 210 29 immature immature JJ cord-001397-nrq4ncdf 210 30 virions virion NNS cord-001397-nrq4ncdf 210 31 ( ( -LRB- cord-001397-nrq4ncdf 210 32 h h NN cord-001397-nrq4ncdf 210 33 ) ) -RRB- cord-001397-nrq4ncdf 210 34 . . . cord-001397-nrq4ncdf 211 1 The the DT cord-001397-nrq4ncdf 211 2 immature immature JJ cord-001397-nrq4ncdf 211 3 virions virion NNS cord-001397-nrq4ncdf 211 4 transit transit NN cord-001397-nrq4ncdf 211 5 the the DT cord-001397-nrq4ncdf 211 6 Golgi Golgi NNP cord-001397-nrq4ncdf 211 7 membrane membrane NN cord-001397-nrq4ncdf 211 8 system system NN cord-001397-nrq4ncdf 211 9 ( ( -LRB- cord-001397-nrq4ncdf 211 10 i i NN cord-001397-nrq4ncdf 211 11 ) ) -RRB- cord-001397-nrq4ncdf 211 12 , , , cord-001397-nrq4ncdf 211 13 and and CC cord-001397-nrq4ncdf 211 14 as as IN cord-001397-nrq4ncdf 211 15 a a DT cord-001397-nrq4ncdf 211 16 mild mild JJ cord-001397-nrq4ncdf 211 17 pH ph NN cord-001397-nrq4ncdf 211 18 change change NN cord-001397-nrq4ncdf 211 19 occurs occur VBZ cord-001397-nrq4ncdf 211 20 , , , cord-001397-nrq4ncdf 211 21 the the DT cord-001397-nrq4ncdf 211 22 cellular cellular JJ cord-001397-nrq4ncdf 211 23 enzyme enzyme NN cord-001397-nrq4ncdf 211 24 furin furin NN cord-001397-nrq4ncdf 211 25 cleaves cleave VBZ cord-001397-nrq4ncdf 211 26 the the DT cord-001397-nrq4ncdf 211 27 prM prm JJ cord-001397-nrq4ncdf 211 28 - - HYPH cord-001397-nrq4ncdf 211 29 E e NN cord-001397-nrq4ncdf 211 30 linkage linkage NN cord-001397-nrq4ncdf 211 31 ( ( -LRB- cord-001397-nrq4ncdf 211 32 j j NNP cord-001397-nrq4ncdf 211 33 ) ) -RRB- cord-001397-nrq4ncdf 211 34 , , , cord-001397-nrq4ncdf 211 35 allowing allow VBG cord-001397-nrq4ncdf 211 36 the the DT cord-001397-nrq4ncdf 211 37 virus virus NN cord-001397-nrq4ncdf 211 38 particle particle NN cord-001397-nrq4ncdf 211 39 to to TO cord-001397-nrq4ncdf 211 40 assume assume VB cord-001397-nrq4ncdf 211 41 its -PRON- PRP$ cord-001397-nrq4ncdf 211 42 final final JJ cord-001397-nrq4ncdf 211 43 mature mature JJ cord-001397-nrq4ncdf 211 44 stage stage NN cord-001397-nrq4ncdf 211 45 prior prior RB cord-001397-nrq4ncdf 211 46 to to TO cord-001397-nrq4ncdf 211 47 release release VB cord-001397-nrq4ncdf 211 48 from from IN cord-001397-nrq4ncdf 211 49 the the DT cord-001397-nrq4ncdf 211 50 cell cell NN cord-001397-nrq4ncdf 211 51 ( ( -LRB- cord-001397-nrq4ncdf 211 52 k k NNP cord-001397-nrq4ncdf 211 53 ) ) -RRB- cord-001397-nrq4ncdf 211 54 . . . cord-001397-nrq4ncdf 212 1 Defined define VBN cord-001397-nrq4ncdf 212 2 roles role NNS cord-001397-nrq4ncdf 212 3 for for IN cord-001397-nrq4ncdf 212 4 the the DT cord-001397-nrq4ncdf 212 5 individual individual JJ cord-001397-nrq4ncdf 212 6 viral viral JJ cord-001397-nrq4ncdf 212 7 proteins protein NNS cord-001397-nrq4ncdf 212 8 are be VBP cord-001397-nrq4ncdf 212 9 enumerated enumerate VBN cord-001397-nrq4ncdf 212 10 in in IN cord-001397-nrq4ncdf 212 11 Table Table NNP cord-001397-nrq4ncdf 212 12 1 1 CD cord-001397-nrq4ncdf 212 13 . . . cord-001397-nrq4ncdf 213 1 ( ( -LRB- cord-001397-nrq4ncdf 213 2 Tomori Tomori NNP cord-001397-nrq4ncdf 213 3 , , , cord-001397-nrq4ncdf 213 4 2004 2004 CD cord-001397-nrq4ncdf 213 5 ; ; : cord-001397-nrq4ncdf 213 6 Gulati Gulati NNP cord-001397-nrq4ncdf 213 7 & & CC cord-001397-nrq4ncdf 213 8 Maheshwari Maheshwari NNP cord-001397-nrq4ncdf 213 9 , , , cord-001397-nrq4ncdf 213 10 2007 2007 CD cord-001397-nrq4ncdf 213 11 ; ; : cord-001397-nrq4ncdf 213 12 Varatharaj Varatharaj NNP cord-001397-nrq4ncdf 213 13 , , , cord-001397-nrq4ncdf 213 14 2010 2010 CD cord-001397-nrq4ncdf 213 15 ) ) -RRB- cord-001397-nrq4ncdf 213 16 , , , cord-001397-nrq4ncdf 213 17 but but CC cord-001397-nrq4ncdf 213 18 persistence persistence NN cord-001397-nrq4ncdf 213 19 can can MD cord-001397-nrq4ncdf 213 20 not not RB cord-001397-nrq4ncdf 213 21 be be VB cord-001397-nrq4ncdf 213 22 excluded exclude VBN cord-001397-nrq4ncdf 213 23 . . . cord-001397-nrq4ncdf 214 1 Human human JJ cord-001397-nrq4ncdf 214 2 infection infection NN cord-001397-nrq4ncdf 214 3 with with IN cord-001397-nrq4ncdf 214 4 the the DT cord-001397-nrq4ncdf 214 5 encephalitic encephalitic JJ cord-001397-nrq4ncdf 214 6 viruses virus NNS cord-001397-nrq4ncdf 214 7 almost almost RB cord-001397-nrq4ncdf 214 8 always always RB cord-001397-nrq4ncdf 214 9 occurs occur VBZ cord-001397-nrq4ncdf 214 10 following follow VBG cord-001397-nrq4ncdf 214 11 a a DT cord-001397-nrq4ncdf 214 12 bite bite NN cord-001397-nrq4ncdf 214 13 from from IN cord-001397-nrq4ncdf 214 14 infected infected JJ cord-001397-nrq4ncdf 214 15 ticks tick NNS cord-001397-nrq4ncdf 214 16 or or CC cord-001397-nrq4ncdf 214 17 mosquitoes mosquito NNS cord-001397-nrq4ncdf 214 18 ( ( -LRB- cord-001397-nrq4ncdf 214 19 Figs fig NNS cord-001397-nrq4ncdf 214 20 1 1 CD cord-001397-nrq4ncdf 214 21 and and CC cord-001397-nrq4ncdf 214 22 2 2 CD cord-001397-nrq4ncdf 214 23 ) ) -RRB- cord-001397-nrq4ncdf 214 24 . . . cord-001397-nrq4ncdf 215 1 Generally generally RB cord-001397-nrq4ncdf 215 2 , , , cord-001397-nrq4ncdf 215 3 illness illness NN cord-001397-nrq4ncdf 215 4 tends tend VBZ cord-001397-nrq4ncdf 215 5 to to TO cord-001397-nrq4ncdf 215 6 be be VB cord-001397-nrq4ncdf 215 7 biphasic biphasic JJ cord-001397-nrq4ncdf 215 8 . . . cord-001397-nrq4ncdf 216 1 The the DT cord-001397-nrq4ncdf 216 2 first first JJ cord-001397-nrq4ncdf 216 3 phase phase NN cord-001397-nrq4ncdf 216 4 is be VBZ cord-001397-nrq4ncdf 216 5 characterized characterize VBN cord-001397-nrq4ncdf 216 6 by by IN cord-001397-nrq4ncdf 216 7 a a DT cord-001397-nrq4ncdf 216 8 flu flu NN cord-001397-nrq4ncdf 216 9 - - HYPH cord-001397-nrq4ncdf 216 10 like like JJ cord-001397-nrq4ncdf 216 11 illness illness NN cord-001397-nrq4ncdf 216 12 with with IN cord-001397-nrq4ncdf 216 13 symptoms symptom NNS cord-001397-nrq4ncdf 216 14 such such JJ cord-001397-nrq4ncdf 216 15 as as IN cord-001397-nrq4ncdf 216 16 headache headache NN cord-001397-nrq4ncdf 216 17 , , , cord-001397-nrq4ncdf 216 18 arthralgia arthralgia NNP cord-001397-nrq4ncdf 216 19 , , , cord-001397-nrq4ncdf 216 20 and and CC cord-001397-nrq4ncdf 216 21 malaise malaise NN cord-001397-nrq4ncdf 216 22 . . . cord-001397-nrq4ncdf 217 1 The the DT cord-001397-nrq4ncdf 217 2 second second JJ cord-001397-nrq4ncdf 217 3 phase phase NN cord-001397-nrq4ncdf 217 4 may may MD cord-001397-nrq4ncdf 217 5 present present VB cord-001397-nrq4ncdf 217 6 with with IN cord-001397-nrq4ncdf 217 7 neurological neurological JJ cord-001397-nrq4ncdf 217 8 symptoms symptom NNS cord-001397-nrq4ncdf 217 9 , , , cord-001397-nrq4ncdf 217 10 such such JJ cord-001397-nrq4ncdf 217 11 as as IN cord-001397-nrq4ncdf 217 12 mild mild JJ cord-001397-nrq4ncdf 217 13 meningitis meningitis NN cord-001397-nrq4ncdf 217 14 to to IN cord-001397-nrq4ncdf 217 15 severe severe JJ cord-001397-nrq4ncdf 217 16 encephalitis encephalitis RB cord-001397-nrq4ncdf 217 17 . . . cord-001397-nrq4ncdf 218 1 Survivors survivor NNS cord-001397-nrq4ncdf 218 2 of of IN cord-001397-nrq4ncdf 218 3 encephalitis encephalitis NN cord-001397-nrq4ncdf 218 4 may may MD cord-001397-nrq4ncdf 218 5 develop develop VB cord-001397-nrq4ncdf 218 6 persistent persistent JJ cord-001397-nrq4ncdf 218 7 neurological neurological JJ cord-001397-nrq4ncdf 218 8 sequelae sequela NNS cord-001397-nrq4ncdf 218 9 , , , cord-001397-nrq4ncdf 218 10 suggesting suggest VBG cord-001397-nrq4ncdf 218 11 neurological neurological JJ cord-001397-nrq4ncdf 218 12 tissue tissue NN cord-001397-nrq4ncdf 218 13 damage damage NN cord-001397-nrq4ncdf 218 14 and/ and/ CD cord-001397-nrq4ncdf 218 15 or or CC cord-001397-nrq4ncdf 218 16 viral viral JJ cord-001397-nrq4ncdf 218 17 persistence persistence NN cord-001397-nrq4ncdf 218 18 . . . cord-001397-nrq4ncdf 219 1 Neurological neurological JJ cord-001397-nrq4ncdf 219 2 tissue tissue NN cord-001397-nrq4ncdf 219 3 damage damage NN cord-001397-nrq4ncdf 219 4 , , , cord-001397-nrq4ncdf 219 5 such such JJ cord-001397-nrq4ncdf 219 6 as as IN cord-001397-nrq4ncdf 219 7 loss loss NN cord-001397-nrq4ncdf 219 8 of of IN cord-001397-nrq4ncdf 219 9 neurons neuron NNS cord-001397-nrq4ncdf 219 10 , , , cord-001397-nrq4ncdf 219 11 has have VBZ cord-001397-nrq4ncdf 219 12 been be VBN cord-001397-nrq4ncdf 219 13 reported report VBN cord-001397-nrq4ncdf 219 14 for for IN cord-001397-nrq4ncdf 219 15 WNV WNV NNP cord-001397-nrq4ncdf 219 16 infection infection NN cord-001397-nrq4ncdf 219 17 ( ( -LRB- cord-001397-nrq4ncdf 219 18 Guarner Guarner NNP cord-001397-nrq4ncdf 219 19 et et NNP cord-001397-nrq4ncdf 219 20 al al NNP cord-001397-nrq4ncdf 219 21 . . NNP cord-001397-nrq4ncdf 219 22 , , , cord-001397-nrq4ncdf 219 23 2004 2004 CD cord-001397-nrq4ncdf 219 24 ) ) -RRB- cord-001397-nrq4ncdf 219 25 . . . cord-001397-nrq4ncdf 220 1 Long long JJ cord-001397-nrq4ncdf 220 2 - - HYPH cord-001397-nrq4ncdf 220 3 term term NN cord-001397-nrq4ncdf 220 4 morbidity morbidity NN cord-001397-nrq4ncdf 220 5 following follow VBG cord-001397-nrq4ncdf 220 6 TBEV TBEV NNP cord-001397-nrq4ncdf 220 7 infection infection NN cord-001397-nrq4ncdf 220 8 is be VBZ cord-001397-nrq4ncdf 220 9 known know VBN cord-001397-nrq4ncdf 220 10 to to TO cord-001397-nrq4ncdf 220 11 occur occur VB cord-001397-nrq4ncdf 220 12 frequently frequently RB cord-001397-nrq4ncdf 221 1 ( ( -LRB- cord-001397-nrq4ncdf 221 2 Haglund Haglund NNP cord-001397-nrq4ncdf 221 3 et et FW cord-001397-nrq4ncdf 221 4 al al NNP cord-001397-nrq4ncdf 221 5 . . NNP cord-001397-nrq4ncdf 221 6 , , , cord-001397-nrq4ncdf 221 7 1996 1996 CD cord-001397-nrq4ncdf 221 8 ; ; : cord-001397-nrq4ncdf 221 9 Haglund Haglund NNP cord-001397-nrq4ncdf 221 10 & & CC cord-001397-nrq4ncdf 221 11 Gunther Gunther NNP cord-001397-nrq4ncdf 221 12 , , , cord-001397-nrq4ncdf 221 13 2003 2003 CD cord-001397-nrq4ncdf 221 14 ) ) -RRB- cord-001397-nrq4ncdf 221 15 . . . cord-001397-nrq4ncdf 222 1 A a DT cord-001397-nrq4ncdf 222 2 study study NN cord-001397-nrq4ncdf 222 3 conducted conduct VBN cord-001397-nrq4ncdf 222 4 in in IN cord-001397-nrq4ncdf 222 5 Sweden Sweden NNP cord-001397-nrq4ncdf 222 6 reported report VBD cord-001397-nrq4ncdf 222 7 chronic chronic JJ cord-001397-nrq4ncdf 222 8 postencephalitic postencephalitic JJ cord-001397-nrq4ncdf 222 9 syndrome syndrome NN cord-001397-nrq4ncdf 222 10 in in IN cord-001397-nrq4ncdf 222 11 36 36 CD cord-001397-nrq4ncdf 222 12 % % NN cord-001397-nrq4ncdf 222 13 of of IN cord-001397-nrq4ncdf 222 14 patients patient NNS cord-001397-nrq4ncdf 222 15 who who WP cord-001397-nrq4ncdf 222 16 had have VBD cord-001397-nrq4ncdf 222 17 been be VBN cord-001397-nrq4ncdf 222 18 infected infect VBN cord-001397-nrq4ncdf 222 19 with with IN cord-001397-nrq4ncdf 222 20 TBEV TBEV NNP cord-001397-nrq4ncdf 222 21 ( ( -LRB- cord-001397-nrq4ncdf 222 22 Haglund Haglund NNP cord-001397-nrq4ncdf 222 23 et et FW cord-001397-nrq4ncdf 222 24 al al NNP cord-001397-nrq4ncdf 222 25 . . NNP cord-001397-nrq4ncdf 222 26 , , , cord-001397-nrq4ncdf 222 27 1996 1996 CD cord-001397-nrq4ncdf 222 28 ) ) -RRB- cord-001397-nrq4ncdf 222 29 . . . cord-001397-nrq4ncdf 223 1 In in IN cord-001397-nrq4ncdf 223 2 up up IN cord-001397-nrq4ncdf 223 3 to to TO cord-001397-nrq4ncdf 223 4 60 60 CD cord-001397-nrq4ncdf 223 5 % % NN cord-001397-nrq4ncdf 223 6 of of IN cord-001397-nrq4ncdf 223 7 patients patient NNS cord-001397-nrq4ncdf 223 8 who who WP cord-001397-nrq4ncdf 223 9 develop develop VBP cord-001397-nrq4ncdf 223 10 encephalitis encephalitis RB cord-001397-nrq4ncdf 223 11 due due IN cord-001397-nrq4ncdf 223 12 to to IN cord-001397-nrq4ncdf 223 13 WNV WNV NNP cord-001397-nrq4ncdf 223 14 infection infection NN cord-001397-nrq4ncdf 223 15 , , , cord-001397-nrq4ncdf 223 16 neurological neurological JJ cord-001397-nrq4ncdf 223 17 and/or and/or CC cord-001397-nrq4ncdf 223 18 neuropsychological neuropsychological JJ cord-001397-nrq4ncdf 223 19 symptoms symptom NNS cord-001397-nrq4ncdf 223 20 continue continue VBP cord-001397-nrq4ncdf 223 21 to to TO cord-001397-nrq4ncdf 223 22 be be VB cord-001397-nrq4ncdf 223 23 reported report VBN cord-001397-nrq4ncdf 223 24 for for IN cord-001397-nrq4ncdf 223 25 up up IN cord-001397-nrq4ncdf 223 26 to to TO cord-001397-nrq4ncdf 223 27 7 7 CD cord-001397-nrq4ncdf 223 28 years year NNS cord-001397-nrq4ncdf 223 29 following follow VBG cord-001397-nrq4ncdf 223 30 the the DT cord-001397-nrq4ncdf 223 31 infection infection NN cord-001397-nrq4ncdf 223 32 ( ( -LRB- cord-001397-nrq4ncdf 223 33 Murray Murray NNP cord-001397-nrq4ncdf 223 34 et et NNP cord-001397-nrq4ncdf 223 35 al al NNP cord-001397-nrq4ncdf 223 36 . . NNP cord-001397-nrq4ncdf 223 37 , , , cord-001397-nrq4ncdf 223 38 2010 2010 CD cord-001397-nrq4ncdf 223 39 ; ; : cord-001397-nrq4ncdf 223 40 Sadek Sadek NNP cord-001397-nrq4ncdf 223 41 et et NNP cord-001397-nrq4ncdf 223 42 al al NNP cord-001397-nrq4ncdf 223 43 . . NNP cord-001397-nrq4ncdf 223 44 , , , cord-001397-nrq4ncdf 223 45 2010 2010 CD cord-001397-nrq4ncdf 223 46 ) ) -RRB- cord-001397-nrq4ncdf 223 47 . . . cord-001397-nrq4ncdf 224 1 The the DT cord-001397-nrq4ncdf 224 2 most most RBS cord-001397-nrq4ncdf 224 3 definitive definitive JJ cord-001397-nrq4ncdf 224 4 evidence evidence NN cord-001397-nrq4ncdf 224 5 for for IN cord-001397-nrq4ncdf 224 6 viral viral JJ cord-001397-nrq4ncdf 224 7 persistence persistence NN cord-001397-nrq4ncdf 224 8 would would MD cord-001397-nrq4ncdf 224 9 be be VB cord-001397-nrq4ncdf 224 10 the the DT cord-001397-nrq4ncdf 224 11 isolation isolation NN cord-001397-nrq4ncdf 224 12 of of IN cord-001397-nrq4ncdf 224 13 viable viable JJ cord-001397-nrq4ncdf 224 14 virus virus NN cord-001397-nrq4ncdf 224 15 or or CC cord-001397-nrq4ncdf 224 16 the the DT cord-001397-nrq4ncdf 224 17 demonstration demonstration NN cord-001397-nrq4ncdf 224 18 of of IN cord-001397-nrq4ncdf 224 19 viral viral JJ cord-001397-nrq4ncdf 224 20 antigens antigen NNS cord-001397-nrq4ncdf 224 21 or or CC cord-001397-nrq4ncdf 224 22 RNA RNA NNP cord-001397-nrq4ncdf 224 23 long long RB cord-001397-nrq4ncdf 224 24 after after IN cord-001397-nrq4ncdf 224 25 the the DT cord-001397-nrq4ncdf 224 26 acute acute JJ cord-001397-nrq4ncdf 224 27 illness illness NN cord-001397-nrq4ncdf 224 28 . . . cord-001397-nrq4ncdf 225 1 Several several JJ cord-001397-nrq4ncdf 225 2 reports report NNS cord-001397-nrq4ncdf 225 3 describe describe VBP cord-001397-nrq4ncdf 225 4 the the DT cord-001397-nrq4ncdf 225 5 isolation isolation NN cord-001397-nrq4ncdf 225 6 of of IN cord-001397-nrq4ncdf 225 7 infectious infectious JJ cord-001397-nrq4ncdf 225 8 VBFVs vbfv NNS cord-001397-nrq4ncdf 225 9 from from IN cord-001397-nrq4ncdf 225 10 persistently persistently RB cord-001397-nrq4ncdf 225 11 infected infect VBN cord-001397-nrq4ncdf 225 12 humans human NNS cord-001397-nrq4ncdf 225 13 . . . cord-001397-nrq4ncdf 226 1 For for IN cord-001397-nrq4ncdf 226 2 example example NN cord-001397-nrq4ncdf 226 3 , , , cord-001397-nrq4ncdf 226 4 the the DT cord-001397-nrq4ncdf 226 5 Siberian Siberian NNP cord-001397-nrq4ncdf 226 6 TBEV TBEV NNP cord-001397-nrq4ncdf 226 7 strain strain NN cord-001397-nrq4ncdf 226 8 Za Za NNP cord-001397-nrq4ncdf 226 9 was be VBD cord-001397-nrq4ncdf 226 10 isolated isolate VBN cord-001397-nrq4ncdf 226 11 from from IN cord-001397-nrq4ncdf 226 12 an an DT cord-001397-nrq4ncdf 226 13 individual individual NN cord-001397-nrq4ncdf 226 14 who who WP cord-001397-nrq4ncdf 226 15 had have VBD cord-001397-nrq4ncdf 226 16 harbored harbor VBN cord-001397-nrq4ncdf 226 17 the the DT cord-001397-nrq4ncdf 226 18 virus virus NN cord-001397-nrq4ncdf 226 19 for for IN cord-001397-nrq4ncdf 226 20 10 10 CD cord-001397-nrq4ncdf 226 21 years year NNS cord-001397-nrq4ncdf 227 1 ( ( -LRB- cord-001397-nrq4ncdf 227 2 Gritsun Gritsun NNP cord-001397-nrq4ncdf 227 3 et et NNP cord-001397-nrq4ncdf 227 4 al al NNP cord-001397-nrq4ncdf 227 5 . . NNP cord-001397-nrq4ncdf 227 6 , , , cord-001397-nrq4ncdf 227 7 2003 2003 CD cord-001397-nrq4ncdf 227 8 ) ) -RRB- cord-001397-nrq4ncdf 227 9 . . . cord-001397-nrq4ncdf 228 1 He -PRON- PRP cord-001397-nrq4ncdf 228 2 later later RB cord-001397-nrq4ncdf 228 3 died die VBD cord-001397-nrq4ncdf 228 4 following follow VBG cord-001397-nrq4ncdf 228 5 2 2 CD cord-001397-nrq4ncdf 228 6 years year NNS cord-001397-nrq4ncdf 228 7 of of IN cord-001397-nrq4ncdf 228 8 a a DT cord-001397-nrq4ncdf 228 9 progressive progressive JJ cord-001397-nrq4ncdf 228 10 form form NN cord-001397-nrq4ncdf 228 11 of of IN cord-001397-nrq4ncdf 228 12 TBEV TBEV NNP cord-001397-nrq4ncdf 228 13 encephalitis encephalitis RB cord-001397-nrq4ncdf 228 14 ( ( -LRB- cord-001397-nrq4ncdf 228 15 Gritsun Gritsun NNP cord-001397-nrq4ncdf 228 16 et et NNP cord-001397-nrq4ncdf 228 17 al al NNP cord-001397-nrq4ncdf 228 18 . . NNP cord-001397-nrq4ncdf 228 19 , , , cord-001397-nrq4ncdf 228 20 2003 2003 CD cord-001397-nrq4ncdf 228 21 ) ) -RRB- cord-001397-nrq4ncdf 228 22 . . . cord-001397-nrq4ncdf 229 1 In in IN cord-001397-nrq4ncdf 229 2 addition addition NN cord-001397-nrq4ncdf 229 3 , , , cord-001397-nrq4ncdf 229 4 isolation isolation NN cord-001397-nrq4ncdf 229 5 of of IN cord-001397-nrq4ncdf 229 6 JEV JEV NNP cord-001397-nrq4ncdf 229 7 from from IN cord-001397-nrq4ncdf 229 8 the the DT cord-001397-nrq4ncdf 229 9 cerebrospinal cerebrospinal JJ cord-001397-nrq4ncdf 229 10 fluid fluid NN cord-001397-nrq4ncdf 229 11 was be VBD cord-001397-nrq4ncdf 229 12 possible possible JJ cord-001397-nrq4ncdf 229 13 for for IN cord-001397-nrq4ncdf 229 14 more more JJR cord-001397-nrq4ncdf 229 15 than than IN cord-001397-nrq4ncdf 229 16 3 3 CD cord-001397-nrq4ncdf 229 17 weeks week NNS cord-001397-nrq4ncdf 229 18 following follow VBG cord-001397-nrq4ncdf 229 19 infection infection NN cord-001397-nrq4ncdf 229 20 in in IN cord-001397-nrq4ncdf 229 21 19 19 CD cord-001397-nrq4ncdf 229 22 % % NN cord-001397-nrq4ncdf 229 23 of of IN cord-001397-nrq4ncdf 229 24 individuals individual NNS cord-001397-nrq4ncdf 229 25 that that WDT cord-001397-nrq4ncdf 229 26 had have VBD cord-001397-nrq4ncdf 229 27 developed develop VBN cord-001397-nrq4ncdf 229 28 encephalitis encephalitis JJ cord-001397-nrq4ncdf 229 29 ( ( -LRB- cord-001397-nrq4ncdf 229 30 Ravi Ravi NNP cord-001397-nrq4ncdf 229 31 et et FW cord-001397-nrq4ncdf 229 32 al al NNP cord-001397-nrq4ncdf 229 33 . . NNP cord-001397-nrq4ncdf 229 34 , , , cord-001397-nrq4ncdf 229 35 1993 1993 CD cord-001397-nrq4ncdf 229 36 ) ) -RRB- cord-001397-nrq4ncdf 229 37 . . . cord-001397-nrq4ncdf 230 1 JEV JEV NNP cord-001397-nrq4ncdf 230 2 persistence persistence NN cord-001397-nrq4ncdf 230 3 was be VBD cord-001397-nrq4ncdf 230 4 also also RB cord-001397-nrq4ncdf 230 5 demonstrated demonstrate VBN cord-001397-nrq4ncdf 230 6 in in IN cord-001397-nrq4ncdf 230 7 peripheral peripheral JJ cord-001397-nrq4ncdf 230 8 mononuclear mononuclear JJ cord-001397-nrq4ncdf 230 9 cells cell NNS cord-001397-nrq4ncdf 230 10 in in IN cord-001397-nrq4ncdf 230 11 infected infected JJ cord-001397-nrq4ncdf 230 12 children child NNS cord-001397-nrq4ncdf 230 13 in in IN cord-001397-nrq4ncdf 230 14 northern northern JJ cord-001397-nrq4ncdf 230 15 India India NNP cord-001397-nrq4ncdf 231 1 ( ( -LRB- cord-001397-nrq4ncdf 231 2 Sharma Sharma NNP cord-001397-nrq4ncdf 231 3 et et NNP cord-001397-nrq4ncdf 231 4 al al NNP cord-001397-nrq4ncdf 231 5 . . NNP cord-001397-nrq4ncdf 231 6 , , , cord-001397-nrq4ncdf 231 7 1991 1991 CD cord-001397-nrq4ncdf 231 8 ) ) -RRB- cord-001397-nrq4ncdf 231 9 . . . cord-001397-nrq4ncdf 232 1 In in IN cord-001397-nrq4ncdf 232 2 these these DT cord-001397-nrq4ncdf 232 3 children child NNS cord-001397-nrq4ncdf 232 4 , , , cord-001397-nrq4ncdf 232 5 virus virus NN cord-001397-nrq4ncdf 232 6 could could MD cord-001397-nrq4ncdf 232 7 be be VB cord-001397-nrq4ncdf 232 8 isolated isolate VBN cord-001397-nrq4ncdf 232 9 by by IN cord-001397-nrq4ncdf 232 10 culture culture NN cord-001397-nrq4ncdf 232 11 8 8 CD cord-001397-nrq4ncdf 232 12 - - SYM cord-001397-nrq4ncdf 232 13 9 9 CD cord-001397-nrq4ncdf 232 14 months month NNS cord-001397-nrq4ncdf 232 15 after after IN cord-001397-nrq4ncdf 232 16 acute acute JJ cord-001397-nrq4ncdf 232 17 infection infection NN cord-001397-nrq4ncdf 232 18 ( ( -LRB- cord-001397-nrq4ncdf 232 19 Sharma Sharma NNP cord-001397-nrq4ncdf 232 20 et et NNP cord-001397-nrq4ncdf 232 21 al al NNP cord-001397-nrq4ncdf 232 22 . . NNP cord-001397-nrq4ncdf 232 23 , , , cord-001397-nrq4ncdf 232 24 1991 1991 CD cord-001397-nrq4ncdf 232 25 ) ) -RRB- cord-001397-nrq4ncdf 232 26 . . . cord-001397-nrq4ncdf 233 1 Furthermore furthermore RB cord-001397-nrq4ncdf 233 2 , , , cord-001397-nrq4ncdf 233 3 WNV WNV NNP cord-001397-nrq4ncdf 233 4 has have VBZ cord-001397-nrq4ncdf 233 5 been be VBN cord-001397-nrq4ncdf 233 6 transmitted transmit VBN cord-001397-nrq4ncdf 233 7 to to IN cord-001397-nrq4ncdf 233 8 patients patient NNS cord-001397-nrq4ncdf 233 9 who who WP cord-001397-nrq4ncdf 233 10 had have VBD cord-001397-nrq4ncdf 233 11 received receive VBN cord-001397-nrq4ncdf 233 12 blood blood NN cord-001397-nrq4ncdf 233 13 transfusions transfusion NNS cord-001397-nrq4ncdf 233 14 or or CC cord-001397-nrq4ncdf 233 15 organ organ NN cord-001397-nrq4ncdf 233 16 transplants transplant NNS cord-001397-nrq4ncdf 233 17 from from IN cord-001397-nrq4ncdf 233 18 asymptomatic asymptomatic JJ cord-001397-nrq4ncdf 233 19 donors donor NNS cord-001397-nrq4ncdf 233 20 ( ( -LRB- cord-001397-nrq4ncdf 233 21 Pealer Pealer NNP cord-001397-nrq4ncdf 233 22 et et NNP cord-001397-nrq4ncdf 233 23 al al NNP cord-001397-nrq4ncdf 233 24 . . NNP cord-001397-nrq4ncdf 233 25 , , , cord-001397-nrq4ncdf 233 26 2003 2003 CD cord-001397-nrq4ncdf 233 27 ; ; : cord-001397-nrq4ncdf 233 28 Montgomery Montgomery NNP cord-001397-nrq4ncdf 233 29 et et NNP cord-001397-nrq4ncdf 233 30 al al NNP cord-001397-nrq4ncdf 233 31 . . NNP cord-001397-nrq4ncdf 233 32 , , , cord-001397-nrq4ncdf 233 33 2006 2006 CD cord-001397-nrq4ncdf 233 34 ; ; : cord-001397-nrq4ncdf 233 35 CDC CDC NNP cord-001397-nrq4ncdf 233 36 , , , cord-001397-nrq4ncdf 233 37 2009 2009 CD cord-001397-nrq4ncdf 233 38 ) ) -RRB- cord-001397-nrq4ncdf 233 39 , , , cord-001397-nrq4ncdf 233 40 suggesting suggest VBG cord-001397-nrq4ncdf 233 41 viral viral JJ cord-001397-nrq4ncdf 233 42 persistence persistence NN cord-001397-nrq4ncdf 233 43 in in IN cord-001397-nrq4ncdf 233 44 the the DT cord-001397-nrq4ncdf 233 45 donors donor NNS cord-001397-nrq4ncdf 233 46 as as RB cord-001397-nrq4ncdf 233 47 well well RB cord-001397-nrq4ncdf 233 48 as as IN cord-001397-nrq4ncdf 233 49 stored store VBN cord-001397-nrq4ncdf 233 50 blood blood NN cord-001397-nrq4ncdf 233 51 for for IN cord-001397-nrq4ncdf 233 52 transfusion transfusion NN cord-001397-nrq4ncdf 233 53 . . . cord-001397-nrq4ncdf 234 1 Long long JJ cord-001397-nrq4ncdf 234 2 - - HYPH cord-001397-nrq4ncdf 234 3 term term NN cord-001397-nrq4ncdf 234 4 presence presence NN cord-001397-nrq4ncdf 234 5 of of IN cord-001397-nrq4ncdf 234 6 viral viral JJ cord-001397-nrq4ncdf 234 7 nucleic nucleic JJ cord-001397-nrq4ncdf 234 8 acid acid NN cord-001397-nrq4ncdf 234 9 is be VBZ cord-001397-nrq4ncdf 234 10 another another DT cord-001397-nrq4ncdf 234 11 indicator indicator NN cord-001397-nrq4ncdf 234 12 for for IN cord-001397-nrq4ncdf 234 13 persistent persistent JJ cord-001397-nrq4ncdf 234 14 infection infection NN cord-001397-nrq4ncdf 234 15 ; ; : cord-001397-nrq4ncdf 234 16 however however RB cord-001397-nrq4ncdf 234 17 , , , cord-001397-nrq4ncdf 234 18 study study NN cord-001397-nrq4ncdf 234 19 results result NNS cord-001397-nrq4ncdf 234 20 are be VBP cord-001397-nrq4ncdf 234 21 inconsistent inconsistent JJ cord-001397-nrq4ncdf 234 22 . . . cord-001397-nrq4ncdf 235 1 Viral Viral NNP cord-001397-nrq4ncdf 235 2 RNA RNA NNP cord-001397-nrq4ncdf 235 3 can can MD cord-001397-nrq4ncdf 235 4 be be VB cord-001397-nrq4ncdf 235 5 readily readily RB cord-001397-nrq4ncdf 235 6 sought seek VBN cord-001397-nrq4ncdf 235 7 using use VBG cord-001397-nrq4ncdf 235 8 molecular molecular JJ cord-001397-nrq4ncdf 235 9 biology biology NN cord-001397-nrq4ncdf 235 10 techniques technique NNS cord-001397-nrq4ncdf 235 11 , , , cord-001397-nrq4ncdf 235 12 such such JJ cord-001397-nrq4ncdf 235 13 as as IN cord-001397-nrq4ncdf 235 14 RT RT NNP cord-001397-nrq4ncdf 235 15 - - HYPH cord-001397-nrq4ncdf 235 16 PCR PCR NNP cord-001397-nrq4ncdf 235 17 and and CC cord-001397-nrq4ncdf 235 18 transcription transcription NN cord-001397-nrq4ncdf 235 19 - - HYPH cord-001397-nrq4ncdf 235 20 mediated mediate VBN cord-001397-nrq4ncdf 235 21 amplification amplification NN cord-001397-nrq4ncdf 235 22 ( ( -LRB- cord-001397-nrq4ncdf 235 23 TMA TMA NNP cord-001397-nrq4ncdf 235 24 ) ) -RRB- cord-001397-nrq4ncdf 236 1 ( ( -LRB- cord-001397-nrq4ncdf 236 2 S S NNP cord-001397-nrq4ncdf 236 3 anchez anchez NNP cord-001397-nrq4ncdf 236 4 - - HYPH cord-001397-nrq4ncdf 236 5 Seco Seco NNP cord-001397-nrq4ncdf 236 6 et et NNP cord-001397-nrq4ncdf 236 7 al al NNP cord-001397-nrq4ncdf 236 8 . . NNP cord-001397-nrq4ncdf 236 9 , , , cord-001397-nrq4ncdf 236 10 2005 2005 CD cord-001397-nrq4ncdf 236 11 ; ; : cord-001397-nrq4ncdf 236 12 Muñoz Muñoz NNP cord-001397-nrq4ncdf 236 13 - - HYPH cord-001397-nrq4ncdf 236 14 Jord Jord NNP cord-001397-nrq4ncdf 236 15 an an NNP cord-001397-nrq4ncdf 236 16 et et FW cord-001397-nrq4ncdf 236 17 al al NNP cord-001397-nrq4ncdf 236 18 . . . cord-001397-nrq4ncdf 237 1 , , , cord-001397-nrq4ncdf 237 2 2009 2009 CD cord-001397-nrq4ncdf 237 3 ; ; : cord-001397-nrq4ncdf 237 4 Patel Patel NNP cord-001397-nrq4ncdf 237 5 et et NNP cord-001397-nrq4ncdf 237 6 al al NNP cord-001397-nrq4ncdf 237 7 . . NNP cord-001397-nrq4ncdf 237 8 , , , cord-001397-nrq4ncdf 237 9 2013 2013 CD cord-001397-nrq4ncdf 237 10 ) ) -RRB- cord-001397-nrq4ncdf 237 11 . . . cord-001397-nrq4ncdf 238 1 Using use VBG cord-001397-nrq4ncdf 238 2 TMA TMA NNP cord-001397-nrq4ncdf 238 3 , , , cord-001397-nrq4ncdf 238 4 WNV WNV NNP cord-001397-nrq4ncdf 238 5 RNA RNA NNP cord-001397-nrq4ncdf 238 6 was be VBD cord-001397-nrq4ncdf 238 7 detectable detectable JJ cord-001397-nrq4ncdf 238 8 in in IN cord-001397-nrq4ncdf 238 9 the the DT cord-001397-nrq4ncdf 238 10 blood blood NN cord-001397-nrq4ncdf 238 11 of of IN cord-001397-nrq4ncdf 238 12 donors donor NNS cord-001397-nrq4ncdf 238 13 for for IN cord-001397-nrq4ncdf 238 14 up up IN cord-001397-nrq4ncdf 238 15 to to TO cord-001397-nrq4ncdf 238 16 104 104 CD cord-001397-nrq4ncdf 238 17 days day NNS cord-001397-nrq4ncdf 238 18 following follow VBG cord-001397-nrq4ncdf 238 19 the the DT cord-001397-nrq4ncdf 238 20 index index NN cord-001397-nrq4ncdf 238 21 donation donation NN cord-001397-nrq4ncdf 238 22 Prince Prince NNP cord-001397-nrq4ncdf 238 23 et et NNP cord-001397-nrq4ncdf 238 24 al al NNP cord-001397-nrq4ncdf 238 25 . . NNP cord-001397-nrq4ncdf 238 26 , , , cord-001397-nrq4ncdf 238 27 2008 2008 CD cord-001397-nrq4ncdf 238 28 ) ) -RRB- cord-001397-nrq4ncdf 238 29 . . . cord-001397-nrq4ncdf 239 1 Using use VBG cord-001397-nrq4ncdf 239 2 RT RT NNP cord-001397-nrq4ncdf 239 3 - - HYPH cord-001397-nrq4ncdf 239 4 PCR PCR NNP cord-001397-nrq4ncdf 239 5 , , , cord-001397-nrq4ncdf 239 6 WNV WNV NNP cord-001397-nrq4ncdf 239 7 RNA RNA NNP cord-001397-nrq4ncdf 239 8 could could MD cord-001397-nrq4ncdf 239 9 also also RB cord-001397-nrq4ncdf 239 10 be be VB cord-001397-nrq4ncdf 239 11 detected detect VBN cord-001397-nrq4ncdf 239 12 in in IN cord-001397-nrq4ncdf 239 13 urine urine NN cord-001397-nrq4ncdf 239 14 of of IN cord-001397-nrq4ncdf 239 15 persistently persistently RB cord-001397-nrq4ncdf 239 16 infected infect VBN cord-001397-nrq4ncdf 239 17 individuals individual NNS cord-001397-nrq4ncdf 239 18 for for IN cord-001397-nrq4ncdf 239 19 up up IN cord-001397-nrq4ncdf 239 20 to to TO cord-001397-nrq4ncdf 239 21 6.5 6.5 CD cord-001397-nrq4ncdf 239 22 years year NNS cord-001397-nrq4ncdf 239 23 following follow VBG cord-001397-nrq4ncdf 239 24 the the DT cord-001397-nrq4ncdf 239 25 acute acute JJ cord-001397-nrq4ncdf 239 26 phase phase NN cord-001397-nrq4ncdf 239 27 of of IN cord-001397-nrq4ncdf 239 28 infection infection NN cord-001397-nrq4ncdf 239 29 ( ( -LRB- cord-001397-nrq4ncdf 239 30 Murray Murray NNP cord-001397-nrq4ncdf 239 31 et et NNP cord-001397-nrq4ncdf 239 32 al al NNP cord-001397-nrq4ncdf 239 33 . . NNP cord-001397-nrq4ncdf 239 34 , , , cord-001397-nrq4ncdf 239 35 2010 2010 CD cord-001397-nrq4ncdf 239 36 ) ) -RRB- cord-001397-nrq4ncdf 239 37 , , , cord-001397-nrq4ncdf 239 38 although although IN cord-001397-nrq4ncdf 239 39 virus virus NN cord-001397-nrq4ncdf 239 40 could could MD cord-001397-nrq4ncdf 239 41 not not RB cord-001397-nrq4ncdf 239 42 be be VB cord-001397-nrq4ncdf 239 43 isolated isolate VBN cord-001397-nrq4ncdf 239 44 from from IN cord-001397-nrq4ncdf 239 45 the the DT cord-001397-nrq4ncdf 239 46 RNA RNA NNP cord-001397-nrq4ncdf 239 47 - - HYPH cord-001397-nrq4ncdf 239 48 positive positive JJ cord-001397-nrq4ncdf 239 49 urine urine NN cord-001397-nrq4ncdf 239 50 samples sample NNS cord-001397-nrq4ncdf 239 51 . . . cord-001397-nrq4ncdf 240 1 In in IN cord-001397-nrq4ncdf 240 2 contrast contrast NN cord-001397-nrq4ncdf 240 3 , , , cord-001397-nrq4ncdf 240 4 WNV WNV NNP cord-001397-nrq4ncdf 240 5 RNA RNA NNP cord-001397-nrq4ncdf 240 6 could could MD cord-001397-nrq4ncdf 240 7 not not RB cord-001397-nrq4ncdf 240 8 be be VB cord-001397-nrq4ncdf 240 9 detected detect VBN cord-001397-nrq4ncdf 240 10 after after IN cord-001397-nrq4ncdf 240 11 6 6 CD cord-001397-nrq4ncdf 240 12 years year NNS cord-001397-nrq4ncdf 240 13 in in IN cord-001397-nrq4ncdf 240 14 urine urine NN cord-001397-nrq4ncdf 240 15 in in IN cord-001397-nrq4ncdf 240 16 another another DT cord-001397-nrq4ncdf 240 17 study study NN cord-001397-nrq4ncdf 240 18 reported report VBD cord-001397-nrq4ncdf 240 19 a a DT cord-001397-nrq4ncdf 240 20 year year NN cord-001397-nrq4ncdf 240 21 later later RB cord-001397-nrq4ncdf 240 22 ( ( -LRB- cord-001397-nrq4ncdf 240 23 Gibney Gibney NNP cord-001397-nrq4ncdf 240 24 et et NNP cord-001397-nrq4ncdf 240 25 al al NNP cord-001397-nrq4ncdf 240 26 . . NNP cord-001397-nrq4ncdf 240 27 , , , cord-001397-nrq4ncdf 240 28 2011 2011 CD cord-001397-nrq4ncdf 240 29 ) ) -RRB- cord-001397-nrq4ncdf 240 30 . . . cord-001397-nrq4ncdf 241 1 Baty Baty NNP cord-001397-nrq4ncdf 241 2 and and CC cord-001397-nrq4ncdf 241 3 colleagues colleague NNS cord-001397-nrq4ncdf 241 4 also also RB cord-001397-nrq4ncdf 241 5 failed fail VBD cord-001397-nrq4ncdf 241 6 to to TO cord-001397-nrq4ncdf 241 7 detect detect VB cord-001397-nrq4ncdf 241 8 WNV WNV NNP cord-001397-nrq4ncdf 241 9 RNA RNA NNP cord-001397-nrq4ncdf 241 10 by by IN cord-001397-nrq4ncdf 241 11 RT RT NNP cord-001397-nrq4ncdf 241 12 - - HYPH cord-001397-nrq4ncdf 241 13 PCR PCR NNP cord-001397-nrq4ncdf 241 14 , , , cord-001397-nrq4ncdf 241 15 but but CC cord-001397-nrq4ncdf 241 16 were be VBD cord-001397-nrq4ncdf 241 17 able able JJ cord-001397-nrq4ncdf 241 18 to to TO cord-001397-nrq4ncdf 241 19 detect detect VB cord-001397-nrq4ncdf 241 20 viral viral JJ cord-001397-nrq4ncdf 241 21 RNA RNA NNP cord-001397-nrq4ncdf 241 22 using use VBG cord-001397-nrq4ncdf 241 23 TMA TMA NNP cord-001397-nrq4ncdf 241 24 ( ( -LRB- cord-001397-nrq4ncdf 241 25 Baty Baty NNP cord-001397-nrq4ncdf 241 26 et et NNP cord-001397-nrq4ncdf 241 27 al al NNP cord-001397-nrq4ncdf 241 28 . . NNP cord-001397-nrq4ncdf 241 29 , , , cord-001397-nrq4ncdf 241 30 2012 2012 CD cord-001397-nrq4ncdf 241 31 ) ) -RRB- cord-001397-nrq4ncdf 241 32 . . . cord-001397-nrq4ncdf 242 1 Similarly similarly RB cord-001397-nrq4ncdf 242 2 for for IN cord-001397-nrq4ncdf 242 3 JEV JEV NNP cord-001397-nrq4ncdf 242 4 , , , cord-001397-nrq4ncdf 242 5 viral viral JJ cord-001397-nrq4ncdf 242 6 RNA RNA NNP cord-001397-nrq4ncdf 242 7 could could MD cord-001397-nrq4ncdf 242 8 not not RB cord-001397-nrq4ncdf 242 9 be be VB cord-001397-nrq4ncdf 242 10 detected detect VBN cord-001397-nrq4ncdf 242 11 by by IN cord-001397-nrq4ncdf 242 12 RT RT NNP cord-001397-nrq4ncdf 242 13 - - HYPH cord-001397-nrq4ncdf 242 14 PCR PCR NNP cord-001397-nrq4ncdf 242 15 in in IN cord-001397-nrq4ncdf 242 16 the the DT cord-001397-nrq4ncdf 242 17 individuals individual NNS cord-001397-nrq4ncdf 242 18 who who WP cord-001397-nrq4ncdf 242 19 had have VBD cord-001397-nrq4ncdf 242 20 anti anti JJ cord-001397-nrq4ncdf 242 21 - - JJ cord-001397-nrq4ncdf 242 22 JEV JEV NNP cord-001397-nrq4ncdf 242 23 IgM IgM NNP cord-001397-nrq4ncdf 242 24 antibodies antibody NNS cord-001397-nrq4ncdf 242 25 ( ( -LRB- cord-001397-nrq4ncdf 242 26 Zhao Zhao NNP cord-001397-nrq4ncdf 242 27 et et NNP cord-001397-nrq4ncdf 242 28 al al NNP cord-001397-nrq4ncdf 242 29 . . NNP cord-001397-nrq4ncdf 242 30 , , , cord-001397-nrq4ncdf 242 31 2013 2013 CD cord-001397-nrq4ncdf 242 32 ) ) -RRB- cord-001397-nrq4ncdf 242 33 . . . cord-001397-nrq4ncdf 243 1 In in IN cord-001397-nrq4ncdf 243 2 the the DT cord-001397-nrq4ncdf 243 3 study study NN cord-001397-nrq4ncdf 243 4 by by IN cord-001397-nrq4ncdf 243 5 Gibney Gibney NNP cord-001397-nrq4ncdf 243 6 et et NNP cord-001397-nrq4ncdf 243 7 al al NNP cord-001397-nrq4ncdf 243 8 . . . cord-001397-nrq4ncdf 244 1 ( ( -LRB- cord-001397-nrq4ncdf 244 2 2011 2011 CD cord-001397-nrq4ncdf 244 3 ) ) -RRB- cord-001397-nrq4ncdf 244 4 , , , cord-001397-nrq4ncdf 244 5 WNV WNV NNP cord-001397-nrq4ncdf 244 6 persistence persistence NN cord-001397-nrq4ncdf 244 7 could could MD cord-001397-nrq4ncdf 244 8 not not RB cord-001397-nrq4ncdf 244 9 be be VB cord-001397-nrq4ncdf 244 10 excluded exclude VBN cord-001397-nrq4ncdf 244 11 . . . cord-001397-nrq4ncdf 245 1 Even even RB cord-001397-nrq4ncdf 245 2 though though IN cord-001397-nrq4ncdf 245 3 the the DT cord-001397-nrq4ncdf 245 4 results result NNS cord-001397-nrq4ncdf 245 5 in in IN cord-001397-nrq4ncdf 245 6 these these DT cord-001397-nrq4ncdf 245 7 studies study NNS cord-001397-nrq4ncdf 245 8 are be VBP cord-001397-nrq4ncdf 245 9 somewhat somewhat RB cord-001397-nrq4ncdf 245 10 variable variable JJ cord-001397-nrq4ncdf 245 11 , , , cord-001397-nrq4ncdf 245 12 it -PRON- PRP cord-001397-nrq4ncdf 245 13 seems seem VBZ cord-001397-nrq4ncdf 245 14 reasonable reasonable JJ cord-001397-nrq4ncdf 245 15 to to TO cord-001397-nrq4ncdf 245 16 conclude conclude VB cord-001397-nrq4ncdf 245 17 that that IN cord-001397-nrq4ncdf 245 18 the the DT cord-001397-nrq4ncdf 245 19 presence presence NN cord-001397-nrq4ncdf 245 20 of of IN cord-001397-nrq4ncdf 245 21 viral viral JJ cord-001397-nrq4ncdf 245 22 RNA RNA NNP cord-001397-nrq4ncdf 245 23 can can MD cord-001397-nrq4ncdf 245 24 also also RB cord-001397-nrq4ncdf 245 25 be be VB cord-001397-nrq4ncdf 245 26 taken take VBN cord-001397-nrq4ncdf 245 27 as as IN cord-001397-nrq4ncdf 245 28 an an DT cord-001397-nrq4ncdf 245 29 indicator indicator NN cord-001397-nrq4ncdf 245 30 of of IN cord-001397-nrq4ncdf 245 31 persistent persistent JJ cord-001397-nrq4ncdf 245 32 infection infection NN cord-001397-nrq4ncdf 245 33 . . . cord-001397-nrq4ncdf 246 1 Viral viral JJ cord-001397-nrq4ncdf 246 2 serology serology NN cord-001397-nrq4ncdf 246 3 may may MD cord-001397-nrq4ncdf 246 4 be be VB cord-001397-nrq4ncdf 246 5 an an DT cord-001397-nrq4ncdf 246 6 additional additional JJ cord-001397-nrq4ncdf 246 7 surrogate surrogate JJ cord-001397-nrq4ncdf 246 8 measure measure NN cord-001397-nrq4ncdf 246 9 for for IN cord-001397-nrq4ncdf 246 10 VBFV vbfv NN cord-001397-nrq4ncdf 246 11 persistence persistence NN cord-001397-nrq4ncdf 246 12 . . . cord-001397-nrq4ncdf 247 1 In in IN cord-001397-nrq4ncdf 247 2 general general JJ cord-001397-nrq4ncdf 247 3 , , , cord-001397-nrq4ncdf 247 4 infection infection NN cord-001397-nrq4ncdf 247 5 or or CC cord-001397-nrq4ncdf 247 6 vaccination vaccination NN cord-001397-nrq4ncdf 247 7 leads lead VBZ cord-001397-nrq4ncdf 247 8 to to IN cord-001397-nrq4ncdf 247 9 a a DT cord-001397-nrq4ncdf 247 10 sterilizing sterilize VBG cord-001397-nrq4ncdf 247 11 immunity immunity NN cord-001397-nrq4ncdf 247 12 , , , cord-001397-nrq4ncdf 247 13 but but CC cord-001397-nrq4ncdf 247 14 long long JJ cord-001397-nrq4ncdf 247 15 - - HYPH cord-001397-nrq4ncdf 247 16 term term NN cord-001397-nrq4ncdf 247 17 persistence persistence NN cord-001397-nrq4ncdf 247 18 of of IN cord-001397-nrq4ncdf 247 19 anti anti JJ cord-001397-nrq4ncdf 247 20 - - JJ cord-001397-nrq4ncdf 247 21 VBFV vbfv JJ cord-001397-nrq4ncdf 247 22 IgM igm NN cord-001397-nrq4ncdf 247 23 antibodies antibody NNS cord-001397-nrq4ncdf 247 24 has have VBZ cord-001397-nrq4ncdf 247 25 often often RB cord-001397-nrq4ncdf 247 26 been be VBN cord-001397-nrq4ncdf 247 27 assumed assume VBN cord-001397-nrq4ncdf 247 28 to to TO cord-001397-nrq4ncdf 247 29 indicate indicate VB cord-001397-nrq4ncdf 247 30 continued continued JJ cord-001397-nrq4ncdf 247 31 exposure exposure NN cord-001397-nrq4ncdf 247 32 to to IN cord-001397-nrq4ncdf 247 33 viral viral JJ cord-001397-nrq4ncdf 247 34 antigens antigen NNS cord-001397-nrq4ncdf 247 35 or or CC cord-001397-nrq4ncdf 247 36 virus virus NN cord-001397-nrq4ncdf 247 37 particles particle NNS cord-001397-nrq4ncdf 247 38 ( ( -LRB- cord-001397-nrq4ncdf 247 39 Ravi Ravi NNP cord-001397-nrq4ncdf 247 40 et et FW cord-001397-nrq4ncdf 247 41 al al NNP cord-001397-nrq4ncdf 247 42 . . NNP cord-001397-nrq4ncdf 247 43 , , , cord-001397-nrq4ncdf 247 44 1993 1993 CD cord-001397-nrq4ncdf 247 45 ; ; : cord-001397-nrq4ncdf 247 46 Stiasny Stiasny NNP cord-001397-nrq4ncdf 247 47 et et NNP cord-001397-nrq4ncdf 247 48 al al NNP cord-001397-nrq4ncdf 247 49 . . NNP cord-001397-nrq4ncdf 247 50 , , , cord-001397-nrq4ncdf 247 51 2012 2012 CD cord-001397-nrq4ncdf 247 52 ) ) -RRB- cord-001397-nrq4ncdf 247 53 . . . cord-001397-nrq4ncdf 248 1 An an DT cord-001397-nrq4ncdf 248 2 exception exception NN cord-001397-nrq4ncdf 248 3 to to IN cord-001397-nrq4ncdf 248 4 this this DT cord-001397-nrq4ncdf 248 5 is be VBZ cord-001397-nrq4ncdf 248 6 , , , cord-001397-nrq4ncdf 248 7 of of IN cord-001397-nrq4ncdf 248 8 course course NN cord-001397-nrq4ncdf 248 9 , , , cord-001397-nrq4ncdf 248 10 DENV DENV NNP cord-001397-nrq4ncdf 248 11 where where WRB cord-001397-nrq4ncdf 248 12 antiviral antiviral JJ cord-001397-nrq4ncdf 248 13 antibody antibody NN cord-001397-nrq4ncdf 248 14 plays play VBZ cord-001397-nrq4ncdf 248 15 a a DT cord-001397-nrq4ncdf 248 16 key key JJ cord-001397-nrq4ncdf 248 17 role role NN cord-001397-nrq4ncdf 248 18 in in IN cord-001397-nrq4ncdf 248 19 pathogenesis pathogenesis NN cord-001397-nrq4ncdf 248 20 ( ( -LRB- cord-001397-nrq4ncdf 248 21 Martina Martina NNP cord-001397-nrq4ncdf 248 22 et et NNP cord-001397-nrq4ncdf 248 23 al al NNP cord-001397-nrq4ncdf 248 24 . . . cord-001397-nrq4ncdf 249 1 , , , cord-001397-nrq4ncdf 249 2 2009 2009 CD cord-001397-nrq4ncdf 249 3 ; ; : cord-001397-nrq4ncdf 249 4 Pierson Pierson NNP cord-001397-nrq4ncdf 249 5 , , , cord-001397-nrq4ncdf 249 6 2010 2010 CD cord-001397-nrq4ncdf 249 7 ) ) -RRB- cord-001397-nrq4ncdf 249 8 . . . cord-001397-nrq4ncdf 250 1 IgM IgM NNP cord-001397-nrq4ncdf 250 2 antibodies antibody NNS cord-001397-nrq4ncdf 250 3 induced induce VBN cord-001397-nrq4ncdf 250 4 by by IN cord-001397-nrq4ncdf 250 5 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 250 6 , , , cord-001397-nrq4ncdf 250 7 such such JJ cord-001397-nrq4ncdf 250 8 as as IN cord-001397-nrq4ncdf 250 9 TBEV TBEV NNP cord-001397-nrq4ncdf 250 10 and and CC cord-001397-nrq4ncdf 250 11 WNV WNV NNP cord-001397-nrq4ncdf 250 12 , , , cord-001397-nrq4ncdf 250 13 are be VBP cord-001397-nrq4ncdf 250 14 known know VBN cord-001397-nrq4ncdf 250 15 to to TO cord-001397-nrq4ncdf 250 16 persist persist VB cord-001397-nrq4ncdf 250 17 in in IN cord-001397-nrq4ncdf 250 18 serum serum NN cord-001397-nrq4ncdf 250 19 and and CC cord-001397-nrq4ncdf 250 20 CSF csf NN cord-001397-nrq4ncdf 250 21 for for IN cord-001397-nrq4ncdf 250 22 12 12 CD cord-001397-nrq4ncdf 250 23 months month NNS cord-001397-nrq4ncdf 250 24 or or CC cord-001397-nrq4ncdf 250 25 more more JJR cord-001397-nrq4ncdf 251 1 ( ( -LRB- cord-001397-nrq4ncdf 251 2 Kapoora Kapoora NNP cord-001397-nrq4ncdf 251 3 et et NNP cord-001397-nrq4ncdf 251 4 al al NNP cord-001397-nrq4ncdf 251 5 . . NNP cord-001397-nrq4ncdf 251 6 , , , cord-001397-nrq4ncdf 251 7 2004 2004 CD cord-001397-nrq4ncdf 252 1 ; ; : cord-001397-nrq4ncdf 252 2 Stiasny Stiasny NNP cord-001397-nrq4ncdf 252 3 et et NNP cord-001397-nrq4ncdf 252 4 al al NNP cord-001397-nrq4ncdf 252 5 . . NNP cord-001397-nrq4ncdf 252 6 , , , cord-001397-nrq4ncdf 252 7 2012 2012 CD cord-001397-nrq4ncdf 252 8 ) ) -RRB- cord-001397-nrq4ncdf 252 9 . . . cord-001397-nrq4ncdf 253 1 Indeed indeed RB cord-001397-nrq4ncdf 253 2 , , , cord-001397-nrq4ncdf 253 3 IgM IgM NNP cord-001397-nrq4ncdf 253 4 antibodies antibody NNS cord-001397-nrq4ncdf 253 5 against against IN cord-001397-nrq4ncdf 253 6 TBEV TBEV NNP cord-001397-nrq4ncdf 253 7 persisted persist VBD cord-001397-nrq4ncdf 253 8 for for IN cord-001397-nrq4ncdf 253 9 up up IN cord-001397-nrq4ncdf 253 10 to to TO cord-001397-nrq4ncdf 253 11 32 32 CD cord-001397-nrq4ncdf 253 12 months month NNS cord-001397-nrq4ncdf 253 13 ( ( -LRB- cord-001397-nrq4ncdf 253 14 Stiasny Stiasny NNP cord-001397-nrq4ncdf 253 15 et et NNP cord-001397-nrq4ncdf 253 16 al al NNP cord-001397-nrq4ncdf 253 17 . . NNP cord-001397-nrq4ncdf 253 18 , , , cord-001397-nrq4ncdf 253 19 2012 2012 CD cord-001397-nrq4ncdf 253 20 ) ) -RRB- cord-001397-nrq4ncdf 253 21 . . . cord-001397-nrq4ncdf 254 1 Furthermore furthermore RB cord-001397-nrq4ncdf 254 2 , , , cord-001397-nrq4ncdf 254 3 anti anti JJ cord-001397-nrq4ncdf 254 4 - - JJ cord-001397-nrq4ncdf 254 5 WNV WNV NNP cord-001397-nrq4ncdf 254 6 IgM IgM NNP cord-001397-nrq4ncdf 254 7 antibodies antibody NNS cord-001397-nrq4ncdf 254 8 persist persist VBP cord-001397-nrq4ncdf 254 9 in in IN cord-001397-nrq4ncdf 254 10 previously previously RB cord-001397-nrq4ncdf 254 11 exposed expose VBN cord-001397-nrq4ncdf 254 12 blood blood NN cord-001397-nrq4ncdf 254 13 donors donor NNS cord-001397-nrq4ncdf 254 14 for for IN cord-001397-nrq4ncdf 254 15 up up RB cord-001397-nrq4ncdf 254 16 16 16 CD cord-001397-nrq4ncdf 254 17 months month NNS cord-001397-nrq4ncdf 255 1 Prince Prince NNP cord-001397-nrq4ncdf 255 2 et et NNP cord-001397-nrq4ncdf 255 3 al al NNP cord-001397-nrq4ncdf 255 4 . . NNP cord-001397-nrq4ncdf 255 5 , , , cord-001397-nrq4ncdf 255 6 2008 2008 CD cord-001397-nrq4ncdf 255 7 ) ) -RRB- cord-001397-nrq4ncdf 255 8 . . . cord-001397-nrq4ncdf 256 1 However however RB cord-001397-nrq4ncdf 256 2 , , , cord-001397-nrq4ncdf 256 3 IgM IgM NNP cord-001397-nrq4ncdf 256 4 antibody antibody NN cord-001397-nrq4ncdf 256 5 persistence persistence NN cord-001397-nrq4ncdf 256 6 does do VBZ cord-001397-nrq4ncdf 256 7 not not RB cord-001397-nrq4ncdf 256 8 necessarily necessarily RB cord-001397-nrq4ncdf 256 9 correlate correlate VB cord-001397-nrq4ncdf 256 10 with with IN cord-001397-nrq4ncdf 256 11 infectious infectious JJ cord-001397-nrq4ncdf 256 12 virus virus NN cord-001397-nrq4ncdf 256 13 persistence persistence NN cord-001397-nrq4ncdf 256 14 . . . cord-001397-nrq4ncdf 257 1 For for IN cord-001397-nrq4ncdf 257 2 example example NN cord-001397-nrq4ncdf 257 3 , , , cord-001397-nrq4ncdf 257 4 persistent persistent JJ cord-001397-nrq4ncdf 257 5 IgM IgM NNP cord-001397-nrq4ncdf 257 6 antibodies antibody NNS cord-001397-nrq4ncdf 257 7 against against IN cord-001397-nrq4ncdf 257 8 TBEV TBEV NNP cord-001397-nrq4ncdf 257 9 can can MD cord-001397-nrq4ncdf 257 10 be be VB cord-001397-nrq4ncdf 257 11 detected detect VBN cord-001397-nrq4ncdf 257 12 in in IN cord-001397-nrq4ncdf 257 13 some some DT cord-001397-nrq4ncdf 257 14 cases case NNS cord-001397-nrq4ncdf 257 15 following follow VBG cord-001397-nrq4ncdf 257 16 vaccination vaccination NN cord-001397-nrq4ncdf 257 17 without without IN cord-001397-nrq4ncdf 257 18 active active JJ cord-001397-nrq4ncdf 257 19 viral viral JJ cord-001397-nrq4ncdf 257 20 infection infection NN cord-001397-nrq4ncdf 258 1 ( ( -LRB- cord-001397-nrq4ncdf 258 2 Rendi Rendi NNP cord-001397-nrq4ncdf 258 3 - - HYPH cord-001397-nrq4ncdf 258 4 Wagner Wagner NNP cord-001397-nrq4ncdf 258 5 et et NNP cord-001397-nrq4ncdf 258 6 al al NNP cord-001397-nrq4ncdf 258 7 . . NNP cord-001397-nrq4ncdf 258 8 , , , cord-001397-nrq4ncdf 258 9 2004 2004 CD cord-001397-nrq4ncdf 258 10 ; ; : cord-001397-nrq4ncdf 258 11 Stiasny Stiasny NNP cord-001397-nrq4ncdf 258 12 et et NNP cord-001397-nrq4ncdf 258 13 al al NNP cord-001397-nrq4ncdf 258 14 . . NNP cord-001397-nrq4ncdf 258 15 , , , cord-001397-nrq4ncdf 258 16 2012 2012 CD cord-001397-nrq4ncdf 258 17 ) ) -RRB- cord-001397-nrq4ncdf 258 18 . . . cord-001397-nrq4ncdf 259 1 For for IN cord-001397-nrq4ncdf 259 2 WNV WNV NNP cord-001397-nrq4ncdf 259 3 infection infection NN cord-001397-nrq4ncdf 259 4 , , , cord-001397-nrq4ncdf 259 5 IgM IgM NNP cord-001397-nrq4ncdf 259 6 antibodies antibody NNS cord-001397-nrq4ncdf 259 7 against against IN cord-001397-nrq4ncdf 259 8 the the DT cord-001397-nrq4ncdf 259 9 nonstructural nonstructural JJ cord-001397-nrq4ncdf 259 10 protein protein NN cord-001397-nrq4ncdf 259 11 NS5 NS5 NNP cord-001397-nrq4ncdf 259 12 can can MD cord-001397-nrq4ncdf 259 13 not not RB cord-001397-nrq4ncdf 259 14 be be VB cord-001397-nrq4ncdf 259 15 used use VBN cord-001397-nrq4ncdf 259 16 to to TO cord-001397-nrq4ncdf 259 17 distinguish distinguish VB cord-001397-nrq4ncdf 259 18 between between IN cord-001397-nrq4ncdf 259 19 recent recent JJ cord-001397-nrq4ncdf 259 20 / / SYM cord-001397-nrq4ncdf 259 21 active active JJ cord-001397-nrq4ncdf 259 22 infection infection NN cord-001397-nrq4ncdf 259 23 from from IN cord-001397-nrq4ncdf 259 24 past past JJ cord-001397-nrq4ncdf 259 25 infection infection NN cord-001397-nrq4ncdf 260 1 ( ( -LRB- cord-001397-nrq4ncdf 260 2 Prince Prince NNP cord-001397-nrq4ncdf 260 3 et et NNP cord-001397-nrq4ncdf 260 4 al al NNP cord-001397-nrq4ncdf 260 5 . . NNP cord-001397-nrq4ncdf 260 6 , , , cord-001397-nrq4ncdf 260 7 2008 2008 CD cord-001397-nrq4ncdf 260 8 ) ) -RRB- cord-001397-nrq4ncdf 260 9 . . . cord-001397-nrq4ncdf 261 1 Thus thus RB cord-001397-nrq4ncdf 261 2 , , , cord-001397-nrq4ncdf 261 3 serology serology NN cord-001397-nrq4ncdf 261 4 may may MD cord-001397-nrq4ncdf 261 5 be be VB cord-001397-nrq4ncdf 261 6 a a DT cord-001397-nrq4ncdf 261 7 less less RBR cord-001397-nrq4ncdf 261 8 useful useful JJ cord-001397-nrq4ncdf 261 9 marker marker NN cord-001397-nrq4ncdf 261 10 for for IN cord-001397-nrq4ncdf 261 11 viral viral JJ cord-001397-nrq4ncdf 261 12 persistence persistence NN cord-001397-nrq4ncdf 261 13 . . . cord-001397-nrq4ncdf 262 1 A a DT cord-001397-nrq4ncdf 262 2 major major JJ cord-001397-nrq4ncdf 262 3 consideration consideration NN cord-001397-nrq4ncdf 262 4 in in IN cord-001397-nrq4ncdf 262 5 VBFV VBFV NNP cord-001397-nrq4ncdf 262 6 in in IN cord-001397-nrq4ncdf 262 7 humans human NNS cord-001397-nrq4ncdf 262 8 would would MD cord-001397-nrq4ncdf 262 9 be be VB cord-001397-nrq4ncdf 262 10 identification identification NN cord-001397-nrq4ncdf 262 11 of of IN cord-001397-nrq4ncdf 262 12 sites site NNS cord-001397-nrq4ncdf 262 13 of of IN cord-001397-nrq4ncdf 262 14 viral viral JJ cord-001397-nrq4ncdf 262 15 persistence persistence NN cord-001397-nrq4ncdf 262 16 . . . cord-001397-nrq4ncdf 263 1 As as IN cord-001397-nrq4ncdf 263 2 flavivirus flavivirus JJ cord-001397-nrq4ncdf 263 3 persistence persistence NN cord-001397-nrq4ncdf 263 4 seems seem VBZ cord-001397-nrq4ncdf 263 5 to to TO cord-001397-nrq4ncdf 263 6 be be VB cord-001397-nrq4ncdf 263 7 mainly mainly RB cord-001397-nrq4ncdf 263 8 associated associate VBN cord-001397-nrq4ncdf 263 9 with with IN cord-001397-nrq4ncdf 263 10 the the DT cord-001397-nrq4ncdf 263 11 neurotropic neurotropic NNP cord-001397-nrq4ncdf 263 12 and and CC cord-001397-nrq4ncdf 263 13 encephalitogenic encephalitogenic NNP cord-001397-nrq4ncdf 263 14 viruses virus NNS cord-001397-nrq4ncdf 263 15 , , , cord-001397-nrq4ncdf 263 16 the the DT cord-001397-nrq4ncdf 263 17 central central JJ cord-001397-nrq4ncdf 263 18 nervous nervous JJ cord-001397-nrq4ncdf 263 19 system system NN cord-001397-nrq4ncdf 263 20 may may MD cord-001397-nrq4ncdf 263 21 well well RB cord-001397-nrq4ncdf 263 22 be be VB cord-001397-nrq4ncdf 263 23 the the DT cord-001397-nrq4ncdf 263 24 preferred preferred JJ cord-001397-nrq4ncdf 263 25 site site NN cord-001397-nrq4ncdf 263 26 for for IN cord-001397-nrq4ncdf 263 27 viral viral JJ cord-001397-nrq4ncdf 263 28 persistence persistence NN cord-001397-nrq4ncdf 263 29 . . . cord-001397-nrq4ncdf 264 1 Furthermore furthermore RB cord-001397-nrq4ncdf 264 2 , , , cord-001397-nrq4ncdf 264 3 this this DT cord-001397-nrq4ncdf 264 4 may may MD cord-001397-nrq4ncdf 264 5 account account VB cord-001397-nrq4ncdf 264 6 for for IN cord-001397-nrq4ncdf 264 7 why why WRB cord-001397-nrq4ncdf 264 8 patients patient NNS cord-001397-nrq4ncdf 264 9 who who WP cord-001397-nrq4ncdf 264 10 recover recover VBP cord-001397-nrq4ncdf 264 11 from from IN cord-001397-nrq4ncdf 264 12 encephalitis encephalitis RBR cord-001397-nrq4ncdf 264 13 often often RB cord-001397-nrq4ncdf 264 14 have have VBP cord-001397-nrq4ncdf 264 15 prolonged prolong VBN cord-001397-nrq4ncdf 264 16 neurological neurological JJ cord-001397-nrq4ncdf 264 17 symptoms symptom NNS cord-001397-nrq4ncdf 264 18 . . . cord-001397-nrq4ncdf 265 1 However however RB cord-001397-nrq4ncdf 265 2 , , , cord-001397-nrq4ncdf 265 3 other other JJ cord-001397-nrq4ncdf 265 4 studies study NNS cord-001397-nrq4ncdf 265 5 by by IN cord-001397-nrq4ncdf 265 6 Murray Murray NNP cord-001397-nrq4ncdf 265 7 and and CC cord-001397-nrq4ncdf 265 8 colleagues colleague NNS cord-001397-nrq4ncdf 265 9 postulated postulate VBD cord-001397-nrq4ncdf 265 10 kidneys kidney NNS cord-001397-nrq4ncdf 265 11 as as IN cord-001397-nrq4ncdf 265 12 a a DT cord-001397-nrq4ncdf 265 13 preferred preferred JJ cord-001397-nrq4ncdf 265 14 site site NN cord-001397-nrq4ncdf 265 15 for for IN cord-001397-nrq4ncdf 265 16 the the DT cord-001397-nrq4ncdf 265 17 establishment establishment NN cord-001397-nrq4ncdf 265 18 of of IN cord-001397-nrq4ncdf 265 19 persistent persistent JJ cord-001397-nrq4ncdf 265 20 flavivirus flavivirus JJ cord-001397-nrq4ncdf 265 21 infections infection NNS cord-001397-nrq4ncdf 265 22 following follow VBG cord-001397-nrq4ncdf 265 23 the the DT cord-001397-nrq4ncdf 265 24 detection detection NN cord-001397-nrq4ncdf 265 25 of of IN cord-001397-nrq4ncdf 265 26 WNV WNV NNP cord-001397-nrq4ncdf 265 27 RNA RNA NNP cord-001397-nrq4ncdf 265 28 in in IN cord-001397-nrq4ncdf 265 29 urine urine NN cord-001397-nrq4ncdf 265 30 ( ( -LRB- cord-001397-nrq4ncdf 265 31 Murray Murray NNP cord-001397-nrq4ncdf 265 32 et et NNP cord-001397-nrq4ncdf 265 33 al al NNP cord-001397-nrq4ncdf 265 34 . . NNP cord-001397-nrq4ncdf 265 35 , , , cord-001397-nrq4ncdf 265 36 2010 2010 CD cord-001397-nrq4ncdf 265 37 ) ) -RRB- cord-001397-nrq4ncdf 265 38 . . . cord-001397-nrq4ncdf 266 1 Certainly certainly RB cord-001397-nrq4ncdf 266 2 , , , cord-001397-nrq4ncdf 266 3 additional additional JJ cord-001397-nrq4ncdf 266 4 work work NN cord-001397-nrq4ncdf 266 5 is be VBZ cord-001397-nrq4ncdf 266 6 required require VBN cord-001397-nrq4ncdf 266 7 to to TO cord-001397-nrq4ncdf 266 8 define define VB cord-001397-nrq4ncdf 266 9 the the DT cord-001397-nrq4ncdf 266 10 true true JJ cord-001397-nrq4ncdf 266 11 incidence incidence NN cord-001397-nrq4ncdf 266 12 , , , cord-001397-nrq4ncdf 266 13 the the DT cord-001397-nrq4ncdf 266 14 biology biology NN cord-001397-nrq4ncdf 266 15 , , , cord-001397-nrq4ncdf 266 16 and and CC cord-001397-nrq4ncdf 266 17 the the DT cord-001397-nrq4ncdf 266 18 pathogenic pathogenic JJ cord-001397-nrq4ncdf 266 19 potential potential NN cord-001397-nrq4ncdf 266 20 in in IN cord-001397-nrq4ncdf 266 21 humans human NNS cord-001397-nrq4ncdf 266 22 of of IN cord-001397-nrq4ncdf 266 23 persistent persistent JJ cord-001397-nrq4ncdf 266 24 VBFV VBFV NNP cord-001397-nrq4ncdf 266 25 infections infection NNS cord-001397-nrq4ncdf 266 26 . . . cord-001397-nrq4ncdf 267 1 Arthropod arthropod JJ cord-001397-nrq4ncdf 267 2 hosts host NNS cord-001397-nrq4ncdf 267 3 play play VBP cord-001397-nrq4ncdf 267 4 crucial crucial JJ cord-001397-nrq4ncdf 267 5 roles role NNS cord-001397-nrq4ncdf 267 6 in in IN cord-001397-nrq4ncdf 267 7 the the DT cord-001397-nrq4ncdf 267 8 biology biology NN cord-001397-nrq4ncdf 267 9 of of IN cord-001397-nrq4ncdf 267 10 both both CC cord-001397-nrq4ncdf 267 11 TBFV TBFV NNP cord-001397-nrq4ncdf 267 12 and and CC cord-001397-nrq4ncdf 267 13 MBFV MBFV NNP cord-001397-nrq4ncdf 267 14 and and CC cord-001397-nrq4ncdf 267 15 contribute contribute VB cord-001397-nrq4ncdf 267 16 to to IN cord-001397-nrq4ncdf 267 17 persistent persistent JJ cord-001397-nrq4ncdf 267 18 infection infection NN cord-001397-nrq4ncdf 267 19 . . . cord-001397-nrq4ncdf 268 1 In in IN cord-001397-nrq4ncdf 268 2 nature nature NN cord-001397-nrq4ncdf 268 3 , , , cord-001397-nrq4ncdf 268 4 ticks tick NNS cord-001397-nrq4ncdf 268 5 are be VBP cord-001397-nrq4ncdf 268 6 the the DT cord-001397-nrq4ncdf 268 7 important important JJ cord-001397-nrq4ncdf 268 8 arachnid arachnid JJ cord-001397-nrq4ncdf 268 9 reservoirs reservoir NNS cord-001397-nrq4ncdf 268 10 of of IN cord-001397-nrq4ncdf 268 11 TBFVs tbfv NNS cord-001397-nrq4ncdf 268 12 . . . cord-001397-nrq4ncdf 269 1 The the DT cord-001397-nrq4ncdf 269 2 persistence persistence NN cord-001397-nrq4ncdf 269 3 of of IN cord-001397-nrq4ncdf 269 4 the the DT cord-001397-nrq4ncdf 269 5 TBFVs tbfv NNS cord-001397-nrq4ncdf 269 6 in in IN cord-001397-nrq4ncdf 269 7 arachnids arachnid NNS cord-001397-nrq4ncdf 269 8 is be VBZ cord-001397-nrq4ncdf 269 9 well well RB cord-001397-nrq4ncdf 269 10 established establish VBN cord-001397-nrq4ncdf 269 11 , , , cord-001397-nrq4ncdf 269 12 and and CC cord-001397-nrq4ncdf 269 13 the the DT cord-001397-nrq4ncdf 269 14 role role NN cord-001397-nrq4ncdf 269 15 of of IN cord-001397-nrq4ncdf 269 16 ticks tick NNS cord-001397-nrq4ncdf 269 17 as as IN cord-001397-nrq4ncdf 269 18 long long JJ cord-001397-nrq4ncdf 269 19 - - HYPH cord-001397-nrq4ncdf 269 20 term term NN cord-001397-nrq4ncdf 269 21 reservoirs reservoir NNS cord-001397-nrq4ncdf 269 22 and and CC cord-001397-nrq4ncdf 269 23 vectors vector NNS cord-001397-nrq4ncdf 269 24 for for IN cord-001397-nrq4ncdf 269 25 the the DT cord-001397-nrq4ncdf 269 26 viruses virus NNS cord-001397-nrq4ncdf 269 27 is be VBZ cord-001397-nrq4ncdf 269 28 clear clear JJ cord-001397-nrq4ncdf 269 29 . . . cord-001397-nrq4ncdf 270 1 Estimates estimate NNS cord-001397-nrq4ncdf 270 2 suggest suggest VBP cord-001397-nrq4ncdf 270 3 that that IN cord-001397-nrq4ncdf 270 4 ticks tick NNS cord-001397-nrq4ncdf 270 5 transmit transmit VB cord-001397-nrq4ncdf 270 6 about about RB cord-001397-nrq4ncdf 270 7 25 25 CD cord-001397-nrq4ncdf 270 8 % % NN cord-001397-nrq4ncdf 270 9 of of IN cord-001397-nrq4ncdf 270 10 the the DT cord-001397-nrq4ncdf 270 11 known know VBN cord-001397-nrq4ncdf 270 12 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 270 13 . . . cord-001397-nrq4ncdf 271 1 TBFVs tbfv NNS cord-001397-nrq4ncdf 271 2 are be VBP cord-001397-nrq4ncdf 271 3 capable capable JJ cord-001397-nrq4ncdf 271 4 of of IN cord-001397-nrq4ncdf 271 5 infecting infect VBG cord-001397-nrq4ncdf 271 6 about about RB cord-001397-nrq4ncdf 271 7 14 14 CD cord-001397-nrq4ncdf 271 8 tick tick NN cord-001397-nrq4ncdf 271 9 species specie NNS cord-001397-nrq4ncdf 271 10 , , , cord-001397-nrq4ncdf 271 11 but but CC cord-001397-nrq4ncdf 271 12 the the DT cord-001397-nrq4ncdf 271 13 ixodid ixodid NN cord-001397-nrq4ncdf 271 14 ticks tick NNS cord-001397-nrq4ncdf 271 15 , , , cord-001397-nrq4ncdf 271 16 Ixodes Ixodes NNP cord-001397-nrq4ncdf 271 17 scapularis scapularis NN cord-001397-nrq4ncdf 271 18 and and CC cord-001397-nrq4ncdf 271 19 Ixodes Ixodes NNP cord-001397-nrq4ncdf 271 20 ricinus ricinus NN cord-001397-nrq4ncdf 271 21 , , , cord-001397-nrq4ncdf 271 22 account account VBP cord-001397-nrq4ncdf 271 23 for for IN cord-001397-nrq4ncdf 271 24 nearly nearly RB cord-001397-nrq4ncdf 271 25 all all DT cord-001397-nrq4ncdf 271 26 transmission transmission NN cord-001397-nrq4ncdf 271 27 of of IN cord-001397-nrq4ncdf 271 28 TBEV TBEV NNP cord-001397-nrq4ncdf 271 29 to to IN cord-001397-nrq4ncdf 271 30 humans human NNS cord-001397-nrq4ncdf 271 31 . . . cord-001397-nrq4ncdf 272 1 Ixodes Ixodes NNP cord-001397-nrq4ncdf 272 2 cookei cookei NNP cord-001397-nrq4ncdf 272 3 may may MD cord-001397-nrq4ncdf 272 4 also also RB cord-001397-nrq4ncdf 272 5 harbor harbor VB cord-001397-nrq4ncdf 272 6 POWV POWV NNP cord-001397-nrq4ncdf 272 7 and and CC cord-001397-nrq4ncdf 272 8 DTV DTV NNP cord-001397-nrq4ncdf 272 9 , , , cord-001397-nrq4ncdf 272 10 while while IN cord-001397-nrq4ncdf 272 11 the the DT cord-001397-nrq4ncdf 272 12 soft soft JJ cord-001397-nrq4ncdf 272 13 - - HYPH cord-001397-nrq4ncdf 272 14 bodied bodied JJ cord-001397-nrq4ncdf 272 15 Onithodoros Onithodoros NNP cord-001397-nrq4ncdf 272 16 tick tick NN cord-001397-nrq4ncdf 272 17 transmits transmit VBZ cord-001397-nrq4ncdf 272 18 Alkhurma Alkhurma NNP cord-001397-nrq4ncdf 272 19 virus virus NN cord-001397-nrq4ncdf 272 20 ( ( -LRB- cord-001397-nrq4ncdf 272 21 Main Main NNP cord-001397-nrq4ncdf 272 22 et et FW cord-001397-nrq4ncdf 272 23 al al NNP cord-001397-nrq4ncdf 272 24 . . NNP cord-001397-nrq4ncdf 272 25 , , , cord-001397-nrq4ncdf 272 26 1979 1979 CD cord-001397-nrq4ncdf 272 27 ; ; : cord-001397-nrq4ncdf 272 28 Charrel Charrel NNP cord-001397-nrq4ncdf 272 29 et et NNP cord-001397-nrq4ncdf 272 30 al al NNP cord-001397-nrq4ncdf 272 31 . . NNP cord-001397-nrq4ncdf 272 32 , , , cord-001397-nrq4ncdf 272 33 2007 2007 CD cord-001397-nrq4ncdf 272 34 ) ) -RRB- cord-001397-nrq4ncdf 272 35 . . . cord-001397-nrq4ncdf 273 1 To to TO cord-001397-nrq4ncdf 273 2 transmit transmit VB cord-001397-nrq4ncdf 273 3 virus virus NN cord-001397-nrq4ncdf 273 4 , , , cord-001397-nrq4ncdf 273 5 these these DT cord-001397-nrq4ncdf 273 6 ticks tick NNS cord-001397-nrq4ncdf 273 7 need need VBP cord-001397-nrq4ncdf 273 8 only only RB cord-001397-nrq4ncdf 273 9 15 15 CD cord-001397-nrq4ncdf 273 10 min min NN cord-001397-nrq4ncdf 273 11 of of IN cord-001397-nrq4ncdf 273 12 attachment attachment NN cord-001397-nrq4ncdf 273 13 to to IN cord-001397-nrq4ncdf 273 14 the the DT cord-001397-nrq4ncdf 273 15 host host NN cord-001397-nrq4ncdf 274 1 ( ( -LRB- cord-001397-nrq4ncdf 274 2 Crowder Crowder NNP cord-001397-nrq4ncdf 274 3 et et NNP cord-001397-nrq4ncdf 274 4 al al NNP cord-001397-nrq4ncdf 274 5 . . NNP cord-001397-nrq4ncdf 274 6 , , , cord-001397-nrq4ncdf 274 7 2013 2013 CD cord-001397-nrq4ncdf 274 8 ) ) -RRB- cord-001397-nrq4ncdf 274 9 . . . cord-001397-nrq4ncdf 275 1 The the DT cord-001397-nrq4ncdf 275 2 virus virus NN cord-001397-nrq4ncdf 275 3 is be VBZ cord-001397-nrq4ncdf 275 4 present present JJ cord-001397-nrq4ncdf 275 5 in in IN cord-001397-nrq4ncdf 275 6 the the DT cord-001397-nrq4ncdf 275 7 tick tick NN cord-001397-nrq4ncdf 275 8 salivary salivary NN cord-001397-nrq4ncdf 275 9 glands gland NNS cord-001397-nrq4ncdf 275 10 , , , cord-001397-nrq4ncdf 275 11 and and CC cord-001397-nrq4ncdf 275 12 saliva saliva NN cord-001397-nrq4ncdf 275 13 constituents constituent NNS cord-001397-nrq4ncdf 275 14 enhance enhance VBP cord-001397-nrq4ncdf 275 15 infectivity infectivity NN cord-001397-nrq4ncdf 275 16 ( ( -LRB- cord-001397-nrq4ncdf 275 17 Nuttall Nuttall NNP cord-001397-nrq4ncdf 275 18 & & CC cord-001397-nrq4ncdf 275 19 Labuda Labuda NNP cord-001397-nrq4ncdf 275 20 , , , cord-001397-nrq4ncdf 275 21 2003 2003 CD cord-001397-nrq4ncdf 275 22 ; ; : cord-001397-nrq4ncdf 276 1 Girard Girard NNP cord-001397-nrq4ncdf 276 2 et et NNP cord-001397-nrq4ncdf 276 3 al al NNP cord-001397-nrq4ncdf 276 4 . . NNP cord-001397-nrq4ncdf 276 5 , , , cord-001397-nrq4ncdf 276 6 2004 2004 CD cord-001397-nrq4ncdf 276 7 ) ) -RRB- cord-001397-nrq4ncdf 276 8 . . . cord-001397-nrq4ncdf 277 1 A a DT cord-001397-nrq4ncdf 277 2 recent recent JJ cord-001397-nrq4ncdf 277 3 publication publication NN cord-001397-nrq4ncdf 277 4 revealed reveal VBD cord-001397-nrq4ncdf 277 5 that that IN cord-001397-nrq4ncdf 277 6 a a DT cord-001397-nrq4ncdf 277 7 selected select VBN cord-001397-nrq4ncdf 277 8 subset subset NN cord-001397-nrq4ncdf 277 9 of of IN cord-001397-nrq4ncdf 277 10 salivary salivary JJ cord-001397-nrq4ncdf 277 11 gland gland NN cord-001397-nrq4ncdf 277 12 genes gene NNS cord-001397-nrq4ncdf 277 13 is be VBZ cord-001397-nrq4ncdf 277 14 expressed express VBN cord-001397-nrq4ncdf 277 15 when when WRB cord-001397-nrq4ncdf 277 16 infected infected JJ cord-001397-nrq4ncdf 277 17 ticks tick NNS cord-001397-nrq4ncdf 277 18 feed feed NN cord-001397-nrq4ncdf 277 19 on on IN cord-001397-nrq4ncdf 277 20 na€ na€ JJ cord-001397-nrq4ncdf 277 21 ıve ıve JJ cord-001397-nrq4ncdf 277 22 mice mouse NNS cord-001397-nrq4ncdf 278 1 ( ( -LRB- cord-001397-nrq4ncdf 278 2 McNally McNally NNP cord-001397-nrq4ncdf 278 3 et et NNP cord-001397-nrq4ncdf 278 4 al al NNP cord-001397-nrq4ncdf 278 5 . . NNP cord-001397-nrq4ncdf 278 6 , , , cord-001397-nrq4ncdf 278 7 2012 2012 CD cord-001397-nrq4ncdf 278 8 ) ) -RRB- cord-001397-nrq4ncdf 278 9 . . . cord-001397-nrq4ncdf 279 1 Ticks tick NNS cord-001397-nrq4ncdf 279 2 acquire acquire VBP cord-001397-nrq4ncdf 279 3 the the DT cord-001397-nrq4ncdf 279 4 virus virus NN cord-001397-nrq4ncdf 279 5 while while IN cord-001397-nrq4ncdf 279 6 feeding feed VBG cord-001397-nrq4ncdf 279 7 on on IN cord-001397-nrq4ncdf 279 8 infected infected JJ cord-001397-nrq4ncdf 279 9 rodents rodent NNS cord-001397-nrq4ncdf 279 10 , , , cord-001397-nrq4ncdf 279 11 typically typically RB cord-001397-nrq4ncdf 279 12 by by IN cord-001397-nrq4ncdf 279 13 a a DT cord-001397-nrq4ncdf 279 14 process process NN cord-001397-nrq4ncdf 279 15 called call VBN cord-001397-nrq4ncdf 279 16 ' ' `` cord-001397-nrq4ncdf 279 17 cofeeding cofeede VBG cord-001397-nrq4ncdf 279 18 ' ' '' cord-001397-nrq4ncdf 279 19 ( ( -LRB- cord-001397-nrq4ncdf 279 20 Fig fig NN cord-001397-nrq4ncdf 279 21 . . . cord-001397-nrq4ncdf 280 1 1 1 LS cord-001397-nrq4ncdf 280 2 ; ; : cord-001397-nrq4ncdf 280 3 Labuda Labuda NNP cord-001397-nrq4ncdf 280 4 et et NNP cord-001397-nrq4ncdf 280 5 al al NNP cord-001397-nrq4ncdf 280 6 . . NNP cord-001397-nrq4ncdf 280 7 , , , cord-001397-nrq4ncdf 280 8 1993a 1993a CD cord-001397-nrq4ncdf 280 9 , , , cord-001397-nrq4ncdf 280 10 b b LS cord-001397-nrq4ncdf 280 11 ) ) -RRB- cord-001397-nrq4ncdf 280 12 , , , cord-001397-nrq4ncdf 280 13 and and CC cord-001397-nrq4ncdf 281 1 the the DT cord-001397-nrq4ncdf 281 2 virus virus NN cord-001397-nrq4ncdf 281 3 persists persist VBZ cord-001397-nrq4ncdf 281 4 throughout throughout IN cord-001397-nrq4ncdf 281 5 several several JJ cord-001397-nrq4ncdf 281 6 life life NN cord-001397-nrq4ncdf 281 7 stages stage NNS cord-001397-nrq4ncdf 281 8 . . . cord-001397-nrq4ncdf 282 1 Ticks tick NNS cord-001397-nrq4ncdf 282 2 at at IN cord-001397-nrq4ncdf 282 3 the the DT cord-001397-nrq4ncdf 282 4 larvae larva NNS cord-001397-nrq4ncdf 282 5 , , , cord-001397-nrq4ncdf 282 6 nymph nymph NN cord-001397-nrq4ncdf 282 7 , , , cord-001397-nrq4ncdf 282 8 and and CC cord-001397-nrq4ncdf 282 9 adult adult NN cord-001397-nrq4ncdf 282 10 life life NN cord-001397-nrq4ncdf 282 11 stages stage NNS cord-001397-nrq4ncdf 282 12 can can MD cord-001397-nrq4ncdf 282 13 become become VB cord-001397-nrq4ncdf 282 14 infected infect VBN cord-001397-nrq4ncdf 282 15 by by IN cord-001397-nrq4ncdf 282 16 feeding feed VBG cord-001397-nrq4ncdf 282 17 on on IN cord-001397-nrq4ncdf 282 18 infected infected JJ cord-001397-nrq4ncdf 282 19 animals animal NNS cord-001397-nrq4ncdf 282 20 ( ( -LRB- cord-001397-nrq4ncdf 282 21 horizontal horizontal JJ cord-001397-nrq4ncdf 282 22 transmission transmission NN cord-001397-nrq4ncdf 282 23 ) ) -RRB- cord-001397-nrq4ncdf 282 24 or or CC cord-001397-nrq4ncdf 282 25 can can MD cord-001397-nrq4ncdf 282 26 transmit transmit VB cord-001397-nrq4ncdf 282 27 virus virus NN cord-001397-nrq4ncdf 282 28 vertically vertically RB cord-001397-nrq4ncdf 282 29 across across IN cord-001397-nrq4ncdf 282 30 instars instar NNS cord-001397-nrq4ncdf 282 31 ( ( -LRB- cord-001397-nrq4ncdf 282 32 transstadial transstadial JJ cord-001397-nrq4ncdf 282 33 transmission transmission NN cord-001397-nrq4ncdf 282 34 ) ) -RRB- cord-001397-nrq4ncdf 282 35 and and CC cord-001397-nrq4ncdf 282 36 through through IN cord-001397-nrq4ncdf 282 37 the the DT cord-001397-nrq4ncdf 282 38 eggs egg NNS cord-001397-nrq4ncdf 282 39 ( ( -LRB- cord-001397-nrq4ncdf 282 40 transovarial transovarial JJ cord-001397-nrq4ncdf 282 41 transmission transmission NN cord-001397-nrq4ncdf 282 42 ; ; : cord-001397-nrq4ncdf 282 43 Fig Fig NNP cord-001397-nrq4ncdf 282 44 . . . cord-001397-nrq4ncdf 282 45 1a 1a CD cord-001397-nrq4ncdf 282 46 ; ; . cord-001397-nrq4ncdf 283 1 Labuda Labuda NNP cord-001397-nrq4ncdf 283 2 et et FW cord-001397-nrq4ncdf 283 3 al al NNP cord-001397-nrq4ncdf 283 4 . . . cord-001397-nrq4ncdf 284 1 , , , cord-001397-nrq4ncdf 284 2 1993a 1993a CD cord-001397-nrq4ncdf 285 1 Labuda Labuda NNP cord-001397-nrq4ncdf 285 2 et et FW cord-001397-nrq4ncdf 285 3 al al NNP cord-001397-nrq4ncdf 285 4 . . . cord-001397-nrq4ncdf 286 1 , , , cord-001397-nrq4ncdf 286 2 , , , cord-001397-nrq4ncdf 286 3 1996 1996 CD cord-001397-nrq4ncdf 286 4 Nuttall Nuttall NNP cord-001397-nrq4ncdf 286 5 & & CC cord-001397-nrq4ncdf 286 6 Labuda Labuda NNP cord-001397-nrq4ncdf 286 7 , , , cord-001397-nrq4ncdf 286 8 2003 2003 CD cord-001397-nrq4ncdf 286 9 ) ) -RRB- cord-001397-nrq4ncdf 286 10 . . . cord-001397-nrq4ncdf 287 1 Indeed indeed RB cord-001397-nrq4ncdf 287 2 , , , cord-001397-nrq4ncdf 287 3 results result NNS cord-001397-nrq4ncdf 287 4 of of IN cord-001397-nrq4ncdf 287 5 a a DT cord-001397-nrq4ncdf 287 6 carefully carefully RB cord-001397-nrq4ncdf 287 7 controlled control VBN cord-001397-nrq4ncdf 287 8 study study NN cord-001397-nrq4ncdf 287 9 in in IN cord-001397-nrq4ncdf 287 10 our -PRON- PRP$ cord-001397-nrq4ncdf 287 11 laboratory laboratory NN cord-001397-nrq4ncdf 287 12 show show NN cord-001397-nrq4ncdf 287 13 that that IN cord-001397-nrq4ncdf 287 14 transstadial transstadial JJ cord-001397-nrq4ncdf 287 15 transmission transmission NN cord-001397-nrq4ncdf 287 16 seems seem VBZ cord-001397-nrq4ncdf 287 17 to to TO cord-001397-nrq4ncdf 287 18 be be VB cord-001397-nrq4ncdf 287 19 very very RB cord-001397-nrq4ncdf 287 20 high high JJ cord-001397-nrq4ncdf 288 1 ( ( -LRB- cord-001397-nrq4ncdf 288 2 Mitzel Mitzel NNP cord-001397-nrq4ncdf 288 3 et et NNP cord-001397-nrq4ncdf 288 4 al al NNP cord-001397-nrq4ncdf 288 5 . . NNP cord-001397-nrq4ncdf 288 6 , , , cord-001397-nrq4ncdf 288 7 2007 2007 CD cord-001397-nrq4ncdf 288 8 ) ) -RRB- cord-001397-nrq4ncdf 288 9 . . . cord-001397-nrq4ncdf 289 1 The the DT cord-001397-nrq4ncdf 289 2 blood blood NN cord-001397-nrq4ncdf 289 3 meal meal NN cord-001397-nrq4ncdf 289 4 remains remain VBZ cord-001397-nrq4ncdf 289 5 in in IN cord-001397-nrq4ncdf 289 6 the the DT cord-001397-nrq4ncdf 289 7 midgut midgut NN cord-001397-nrq4ncdf 289 8 for for IN cord-001397-nrq4ncdf 289 9 long long JJ cord-001397-nrq4ncdf 289 10 periods period NNS cord-001397-nrq4ncdf 289 11 of of IN cord-001397-nrq4ncdf 289 12 time time NN cord-001397-nrq4ncdf 289 13 , , , cord-001397-nrq4ncdf 289 14 allowing allow VBG cord-001397-nrq4ncdf 289 15 infection infection NN cord-001397-nrq4ncdf 289 16 of of IN cord-001397-nrq4ncdf 289 17 the the DT cord-001397-nrq4ncdf 289 18 epithelial epithelial JJ cord-001397-nrq4ncdf 289 19 cells cell NNS cord-001397-nrq4ncdf 289 20 lining line VBG cord-001397-nrq4ncdf 289 21 the the DT cord-001397-nrq4ncdf 289 22 midgut midgut NN cord-001397-nrq4ncdf 289 23 with with IN cord-001397-nrq4ncdf 289 24 subsequent subsequent JJ cord-001397-nrq4ncdf 289 25 translocation translocation NN cord-001397-nrq4ncdf 289 26 into into IN cord-001397-nrq4ncdf 289 27 the the DT cord-001397-nrq4ncdf 289 28 hemocoel hemocoel NNP cord-001397-nrq4ncdf 289 29 ( ( -LRB- cord-001397-nrq4ncdf 289 30 Nuttall Nuttall NNP cord-001397-nrq4ncdf 289 31 & & CC cord-001397-nrq4ncdf 289 32 Labuda Labuda NNP cord-001397-nrq4ncdf 289 33 , , , cord-001397-nrq4ncdf 289 34 2003 2003 CD cord-001397-nrq4ncdf 289 35 ) ) -RRB- cord-001397-nrq4ncdf 289 36 . . . cord-001397-nrq4ncdf 290 1 Infection infection NN cord-001397-nrq4ncdf 290 2 of of IN cord-001397-nrq4ncdf 290 3 the the DT cord-001397-nrq4ncdf 290 4 midgut midgut NN cord-001397-nrq4ncdf 290 5 cells cell NNS cord-001397-nrq4ncdf 290 6 may may MD cord-001397-nrq4ncdf 290 7 be be VB cord-001397-nrq4ncdf 290 8 facilitated facilitate VBN cord-001397-nrq4ncdf 290 9 by by IN cord-001397-nrq4ncdf 290 10 the the DT cord-001397-nrq4ncdf 290 11 heterophagous heterophagous JJ cord-001397-nrq4ncdf 290 12 nature nature NN cord-001397-nrq4ncdf 290 13 of of IN cord-001397-nrq4ncdf 290 14 ticks tick NNS cord-001397-nrq4ncdf 290 15 ( ( -LRB- cord-001397-nrq4ncdf 290 16 i.e. i.e. FW cord-001397-nrq4ncdf 290 17 blood blood NN cord-001397-nrq4ncdf 290 18 meal meal NN cord-001397-nrq4ncdf 290 19 digestion digestion NN cord-001397-nrq4ncdf 290 20 is be VBZ cord-001397-nrq4ncdf 290 21 principally principally RB cord-001397-nrq4ncdf 290 22 an an DT cord-001397-nrq4ncdf 290 23 intracellular intracellular JJ cord-001397-nrq4ncdf 290 24 process process NN cord-001397-nrq4ncdf 290 25 ) ) -RRB- cord-001397-nrq4ncdf 290 26 . . . cord-001397-nrq4ncdf 291 1 In in IN cord-001397-nrq4ncdf 291 2 the the DT cord-001397-nrq4ncdf 291 3 open open JJ cord-001397-nrq4ncdf 291 4 circulatory circulatory JJ cord-001397-nrq4ncdf 291 5 system system NN cord-001397-nrq4ncdf 291 6 , , , cord-001397-nrq4ncdf 291 7 tissues tissue NNS cord-001397-nrq4ncdf 291 8 and and CC cord-001397-nrq4ncdf 291 9 organs organ NNS cord-001397-nrq4ncdf 291 10 are be VBP cord-001397-nrq4ncdf 291 11 bathed bathe VBN cord-001397-nrq4ncdf 291 12 in in IN cord-001397-nrq4ncdf 291 13 hemolymph hemolymph NN cord-001397-nrq4ncdf 291 14 , , , cord-001397-nrq4ncdf 291 15 which which WDT cord-001397-nrq4ncdf 291 16 acts act VBZ cord-001397-nrq4ncdf 291 17 as as IN cord-001397-nrq4ncdf 291 18 a a DT cord-001397-nrq4ncdf 291 19 medium medium NN cord-001397-nrq4ncdf 291 20 for for IN cord-001397-nrq4ncdf 291 21 transporting transport VBG cord-001397-nrq4ncdf 291 22 nutrients nutrient NNS cord-001397-nrq4ncdf 291 23 , , , cord-001397-nrq4ncdf 291 24 hormones hormone NNS cord-001397-nrq4ncdf 291 25 , , , cord-001397-nrq4ncdf 291 26 and and CC cord-001397-nrq4ncdf 291 27 immune immune JJ cord-001397-nrq4ncdf 291 28 effector effector NN cord-001397-nrq4ncdf 291 29 molecules molecule NNS cord-001397-nrq4ncdf 291 30 . . . cord-001397-nrq4ncdf 292 1 Therefore therefore RB cord-001397-nrq4ncdf 292 2 , , , cord-001397-nrq4ncdf 292 3 the the DT cord-001397-nrq4ncdf 292 4 hemolymph hemolymph NN cord-001397-nrq4ncdf 292 5 likely likely RB cord-001397-nrq4ncdf 292 6 serves serve VBZ cord-001397-nrq4ncdf 292 7 as as IN cord-001397-nrq4ncdf 292 8 a a DT cord-001397-nrq4ncdf 292 9 viral viral JJ cord-001397-nrq4ncdf 292 10 dissemination dissemination NN cord-001397-nrq4ncdf 292 11 medium medium NN cord-001397-nrq4ncdf 292 12 . . . cord-001397-nrq4ncdf 293 1 TBE TBE NNP cord-001397-nrq4ncdf 293 2 virus virus NN cord-001397-nrq4ncdf 293 3 was be VBD cord-001397-nrq4ncdf 293 4 found find VBN cord-001397-nrq4ncdf 293 5 in in IN cord-001397-nrq4ncdf 293 6 the the DT cord-001397-nrq4ncdf 293 7 esophagus esophagus NN cord-001397-nrq4ncdf 293 8 and and CC cord-001397-nrq4ncdf 293 9 subesophageal subesophageal NN cord-001397-nrq4ncdf 293 10 ganglion ganglion NN cord-001397-nrq4ncdf 293 11 in in IN cord-001397-nrq4ncdf 293 12 Dermacentor Dermacentor NNP cord-001397-nrq4ncdf 293 13 marginatus marginatus NN cord-001397-nrq4ncdf 293 14 larvae larva NNS cord-001397-nrq4ncdf 293 15 and and CC cord-001397-nrq4ncdf 293 16 in in IN cord-001397-nrq4ncdf 293 17 columnar columnar JJ cord-001397-nrq4ncdf 293 18 epidermal epidermal JJ cord-001397-nrq4ncdf 293 19 cells cell NNS cord-001397-nrq4ncdf 293 20 of of IN cord-001397-nrq4ncdf 293 21 Dermacentor Dermacentor NNP cord-001397-nrq4ncdf 293 22 reticulatus reticulatus NN cord-001397-nrq4ncdf 293 23 nymphs nymph NNS cord-001397-nrq4ncdf 293 24 ( ( -LRB- cord-001397-nrq4ncdf 293 25 Nuttall Nuttall NNP cord-001397-nrq4ncdf 293 26 & & CC cord-001397-nrq4ncdf 293 27 Labuda Labuda NNP cord-001397-nrq4ncdf 293 28 , , , cord-001397-nrq4ncdf 293 29 2003 2003 CD cord-001397-nrq4ncdf 293 30 ) ) -RRB- cord-001397-nrq4ncdf 293 31 . . . cord-001397-nrq4ncdf 294 1 In in IN cord-001397-nrq4ncdf 294 2 D. D. NNP cord-001397-nrq4ncdf 294 3 reticulatus reticulatus NN cord-001397-nrq4ncdf 294 4 nymphs nymph NNS cord-001397-nrq4ncdf 294 5 , , , cord-001397-nrq4ncdf 294 6 TBE TBE NNP cord-001397-nrq4ncdf 294 7 virus virus NN cord-001397-nrq4ncdf 294 8 was be VBD cord-001397-nrq4ncdf 294 9 demonstrated demonstrate VBN cord-001397-nrq4ncdf 294 10 in in IN cord-001397-nrq4ncdf 294 11 epidermal epidermal JJ cord-001397-nrq4ncdf 294 12 cells cell NNS cord-001397-nrq4ncdf 294 13 and and CC cord-001397-nrq4ncdf 294 14 in in IN cord-001397-nrq4ncdf 294 15 vacuoles vacuole NNS cord-001397-nrq4ncdf 294 16 in in IN cord-001397-nrq4ncdf 294 17 the the DT cord-001397-nrq4ncdf 294 18 region region NN cord-001397-nrq4ncdf 294 19 of of IN cord-001397-nrq4ncdf 294 20 Golgi Golgi NNP cord-001397-nrq4ncdf 294 21 complexes complex NNS cord-001397-nrq4ncdf 294 22 of of IN cord-001397-nrq4ncdf 294 23 salivary salivary JJ cord-001397-nrq4ncdf 294 24 gland gland NN cord-001397-nrq4ncdf 294 25 cells cell NNS cord-001397-nrq4ncdf 294 26 ( ( -LRB- cord-001397-nrq4ncdf 294 27 Nosek Nosek NNP cord-001397-nrq4ncdf 294 28 et et NNP cord-001397-nrq4ncdf 294 29 al al NNP cord-001397-nrq4ncdf 294 30 . . NNP cord-001397-nrq4ncdf 294 31 , , , cord-001397-nrq4ncdf 294 32 1984 1984 CD cord-001397-nrq4ncdf 294 33 ) ) -RRB- cord-001397-nrq4ncdf 294 34 . . . cord-001397-nrq4ncdf 295 1 The the DT cord-001397-nrq4ncdf 295 2 precise precise JJ cord-001397-nrq4ncdf 295 3 mechanisms mechanism NNS cord-001397-nrq4ncdf 295 4 by by IN cord-001397-nrq4ncdf 295 5 which which WDT cord-001397-nrq4ncdf 295 6 TBFVs tbfvs VBP cord-001397-nrq4ncdf 295 7 traverse traverse JJ cord-001397-nrq4ncdf 295 8 various various JJ cord-001397-nrq4ncdf 295 9 tissues tissue NNS cord-001397-nrq4ncdf 295 10 in in IN cord-001397-nrq4ncdf 295 11 the the DT cord-001397-nrq4ncdf 295 12 tick tick NN cord-001397-nrq4ncdf 295 13 and and CC cord-001397-nrq4ncdf 295 14 reach reach VB cord-001397-nrq4ncdf 295 15 the the DT cord-001397-nrq4ncdf 295 16 salivary salivary JJ cord-001397-nrq4ncdf 295 17 glands gland NNS cord-001397-nrq4ncdf 295 18 remain remain VBP cord-001397-nrq4ncdf 295 19 to to TO cord-001397-nrq4ncdf 295 20 be be VB cord-001397-nrq4ncdf 295 21 fully fully RB cord-001397-nrq4ncdf 295 22 elucidated elucidate VBN cord-001397-nrq4ncdf 295 23 . . . cord-001397-nrq4ncdf 296 1 Prevalence prevalence NN cord-001397-nrq4ncdf 296 2 surveys survey NNS cord-001397-nrq4ncdf 296 3 indicate indicate VBP cord-001397-nrq4ncdf 296 4 that that IN cord-001397-nrq4ncdf 296 5 0.5 0.5 CD cord-001397-nrq4ncdf 296 6 - - SYM cord-001397-nrq4ncdf 296 7 5 5 CD cord-001397-nrq4ncdf 296 8 % % NN cord-001397-nrq4ncdf 296 9 of of IN cord-001397-nrq4ncdf 296 10 ixodid ixodid NN cord-001397-nrq4ncdf 296 11 ticks tick NNS cord-001397-nrq4ncdf 296 12 carry carry VBP cord-001397-nrq4ncdf 296 13 the the DT cord-001397-nrq4ncdf 296 14 virus virus NN cord-001397-nrq4ncdf 296 15 in in IN cord-001397-nrq4ncdf 296 16 Europe Europe NNP cord-001397-nrq4ncdf 296 17 , , , cord-001397-nrq4ncdf 296 18 but but CC cord-001397-nrq4ncdf 296 19 prevalence prevalence NN cord-001397-nrq4ncdf 296 20 of of IN cord-001397-nrq4ncdf 296 21 up up IN cord-001397-nrq4ncdf 296 22 to to TO cord-001397-nrq4ncdf 296 23 40 40 CD cord-001397-nrq4ncdf 296 24 % % NN cord-001397-nrq4ncdf 296 25 has have VBZ cord-001397-nrq4ncdf 296 26 been be VBN cord-001397-nrq4ncdf 296 27 reported report VBN cord-001397-nrq4ncdf 296 28 in in IN cord-001397-nrq4ncdf 296 29 Russia Russia NNP cord-001397-nrq4ncdf 296 30 ( ( -LRB- cord-001397-nrq4ncdf 296 31 Ustinova Ustinova NNP cord-001397-nrq4ncdf 296 32 et et NNP cord-001397-nrq4ncdf 296 33 al al NNP cord-001397-nrq4ncdf 296 34 . . NNP cord-001397-nrq4ncdf 296 35 , , , cord-001397-nrq4ncdf 296 36 1997 1997 CD cord-001397-nrq4ncdf 296 37 ) ) -RRB- cord-001397-nrq4ncdf 296 38 . . . cord-001397-nrq4ncdf 297 1 In in IN cord-001397-nrq4ncdf 297 2 north north JJ cord-001397-nrq4ncdf 297 3 - - HYPH cord-001397-nrq4ncdf 297 4 central central JJ cord-001397-nrq4ncdf 297 5 USA USA NNP cord-001397-nrq4ncdf 297 6 , , , cord-001397-nrq4ncdf 297 7 up up IN cord-001397-nrq4ncdf 297 8 to to TO cord-001397-nrq4ncdf 297 9 4.9 4.9 CD cord-001397-nrq4ncdf 297 10 % % NN cord-001397-nrq4ncdf 297 11 of of IN cord-001397-nrq4ncdf 297 12 I. I. NNP cord-001397-nrq4ncdf 297 13 scapularis scapularis NNP cord-001397-nrq4ncdf 297 14 ticks tick NNS cord-001397-nrq4ncdf 297 15 are be VBP cord-001397-nrq4ncdf 297 16 infected infect VBN cord-001397-nrq4ncdf 297 17 by by IN cord-001397-nrq4ncdf 297 18 Powassan Powassan NNP cord-001397-nrq4ncdf 297 19 or or CC cord-001397-nrq4ncdf 297 20 DTV DTV NNP cord-001397-nrq4ncdf 298 1 ( ( -LRB- cord-001397-nrq4ncdf 298 2 Brackney Brackney NNP cord-001397-nrq4ncdf 298 3 et et NNP cord-001397-nrq4ncdf 298 4 al al NNP cord-001397-nrq4ncdf 298 5 . . NNP cord-001397-nrq4ncdf 298 6 , , , cord-001397-nrq4ncdf 298 7 2008b 2008b CD cord-001397-nrq4ncdf 298 8 ; ; : cord-001397-nrq4ncdf 299 1 Dupuis Dupuis NNP cord-001397-nrq4ncdf 299 2 et et NNP cord-001397-nrq4ncdf 299 3 al al NNP cord-001397-nrq4ncdf 299 4 . . NNP cord-001397-nrq4ncdf 299 5 , , , cord-001397-nrq4ncdf 299 6 2013 2013 CD cord-001397-nrq4ncdf 299 7 ) ) -RRB- cord-001397-nrq4ncdf 299 8 . . . cord-001397-nrq4ncdf 300 1 Interestingly interestingly RB cord-001397-nrq4ncdf 300 2 , , , cord-001397-nrq4ncdf 300 3 in in IN cord-001397-nrq4ncdf 300 4 a a DT cord-001397-nrq4ncdf 300 5 study study NN cord-001397-nrq4ncdf 300 6 carried carry VBN cord-001397-nrq4ncdf 300 7 out out RP cord-001397-nrq4ncdf 300 8 in in IN cord-001397-nrq4ncdf 300 9 Chicago Chicago NNP cord-001397-nrq4ncdf 300 10 , , , cord-001397-nrq4ncdf 300 11 I. I. NNP cord-001397-nrq4ncdf 300 12 scapularis scapularis NNP cord-001397-nrq4ncdf 300 13 was be VBD cord-001397-nrq4ncdf 300 14 found find VBN cord-001397-nrq4ncdf 300 15 to to TO cord-001397-nrq4ncdf 300 16 infest infest VB cord-001397-nrq4ncdf 300 17 2.8 2.8 CD cord-001397-nrq4ncdf 300 18 % % NN cord-001397-nrq4ncdf 300 19 of of IN cord-001397-nrq4ncdf 300 20 wild wild JJ cord-001397-nrq4ncdf 300 21 birds bird NNS cord-001397-nrq4ncdf 300 22 , , , cord-001397-nrq4ncdf 300 23 which which WDT cord-001397-nrq4ncdf 300 24 figure figure VBP cord-001397-nrq4ncdf 300 25 prominently prominently RB cord-001397-nrq4ncdf 300 26 in in IN cord-001397-nrq4ncdf 300 27 the the DT cord-001397-nrq4ncdf 300 28 MBFV MBFV NNP cord-001397-nrq4ncdf 300 29 cycle cycle NN cord-001397-nrq4ncdf 300 30 ( ( -LRB- cord-001397-nrq4ncdf 300 31 Fig fig NN cord-001397-nrq4ncdf 300 32 . . . cord-001397-nrq4ncdf 300 33 1b 1b CD cord-001397-nrq4ncdf 300 34 ; ; : cord-001397-nrq4ncdf 300 35 Hamer Hamer NNP cord-001397-nrq4ncdf 300 36 et et NNP cord-001397-nrq4ncdf 300 37 al al NNP cord-001397-nrq4ncdf 300 38 . . NNP cord-001397-nrq4ncdf 300 39 , , , cord-001397-nrq4ncdf 300 40 2011 2011 CD cord-001397-nrq4ncdf 300 41 ) ) -RRB- cord-001397-nrq4ncdf 300 42 . . . cord-001397-nrq4ncdf 301 1 However however RB cord-001397-nrq4ncdf 301 2 , , , cord-001397-nrq4ncdf 301 3 identification identification NN cord-001397-nrq4ncdf 301 4 of of IN cord-001397-nrq4ncdf 301 5 TBFV TBFV NNP cord-001397-nrq4ncdf 301 6 was be VBD cord-001397-nrq4ncdf 301 7 not not RB cord-001397-nrq4ncdf 301 8 attempted attempt VBN cord-001397-nrq4ncdf 301 9 in in IN cord-001397-nrq4ncdf 301 10 this this DT cord-001397-nrq4ncdf 301 11 study study NN cord-001397-nrq4ncdf 301 12 . . . cord-001397-nrq4ncdf 302 1 In in IN cord-001397-nrq4ncdf 302 2 brief brief JJ cord-001397-nrq4ncdf 302 3 , , , cord-001397-nrq4ncdf 302 4 TBFV tbfv NN cord-001397-nrq4ncdf 302 5 persistence persistence NN cord-001397-nrq4ncdf 302 6 in in IN cord-001397-nrq4ncdf 302 7 ticks tick NNS cord-001397-nrq4ncdf 302 8 is be VBZ cord-001397-nrq4ncdf 302 9 well well RB cord-001397-nrq4ncdf 302 10 established establish VBN cord-001397-nrq4ncdf 302 11 , , , cord-001397-nrq4ncdf 302 12 and and CC cord-001397-nrq4ncdf 302 13 the the DT cord-001397-nrq4ncdf 302 14 essential essential JJ cord-001397-nrq4ncdf 302 15 role role NN cord-001397-nrq4ncdf 302 16 of of IN cord-001397-nrq4ncdf 302 17 ticks tick NNS cord-001397-nrq4ncdf 302 18 in in IN cord-001397-nrq4ncdf 302 19 the the DT cord-001397-nrq4ncdf 302 20 biology biology NN cord-001397-nrq4ncdf 302 21 of of IN cord-001397-nrq4ncdf 302 22 these these DT cord-001397-nrq4ncdf 302 23 viruses virus NNS cord-001397-nrq4ncdf 302 24 is be VBZ cord-001397-nrq4ncdf 302 25 not not RB cord-001397-nrq4ncdf 302 26 in in IN cord-001397-nrq4ncdf 302 27 doubt doubt NN cord-001397-nrq4ncdf 302 28 . . . cord-001397-nrq4ncdf 303 1 As as IN cord-001397-nrq4ncdf 303 2 is be VBZ cord-001397-nrq4ncdf 303 3 the the DT cord-001397-nrq4ncdf 303 4 case case NN cord-001397-nrq4ncdf 303 5 for for IN cord-001397-nrq4ncdf 303 6 TBFVs tbfv NNS cord-001397-nrq4ncdf 303 7 , , , cord-001397-nrq4ncdf 303 8 the the DT cord-001397-nrq4ncdf 303 9 role role NN cord-001397-nrq4ncdf 303 10 of of IN cord-001397-nrq4ncdf 303 11 mosquitoes mosquito NNS cord-001397-nrq4ncdf 303 12 in in IN cord-001397-nrq4ncdf 303 13 the the DT cord-001397-nrq4ncdf 303 14 maintenance maintenance NN cord-001397-nrq4ncdf 303 15 of of IN cord-001397-nrq4ncdf 303 16 the the DT cord-001397-nrq4ncdf 303 17 MBFV MBFV NNP cord-001397-nrq4ncdf 303 18 cycle cycle NN cord-001397-nrq4ncdf 303 19 is be VBZ cord-001397-nrq4ncdf 303 20 also also RB cord-001397-nrq4ncdf 303 21 well well RB cord-001397-nrq4ncdf 303 22 characterized characterize VBN cord-001397-nrq4ncdf 303 23 . . . cord-001397-nrq4ncdf 304 1 Mosquitoes mosquito NNS cord-001397-nrq4ncdf 304 2 are be VBP cord-001397-nrq4ncdf 304 3 thought think VBN cord-001397-nrq4ncdf 304 4 to to TO cord-001397-nrq4ncdf 304 5 account account VB cord-001397-nrq4ncdf 304 6 for for IN cord-001397-nrq4ncdf 304 7 transmitting transmit VBG cord-001397-nrq4ncdf 304 8 approximately approximately RB cord-001397-nrq4ncdf 304 9 50 50 CD cord-001397-nrq4ncdf 304 10 % % NN cord-001397-nrq4ncdf 304 11 of of IN cord-001397-nrq4ncdf 304 12 more more JJR cord-001397-nrq4ncdf 304 13 than than IN cord-001397-nrq4ncdf 304 14 70 70 CD cord-001397-nrq4ncdf 304 15 known know VBN cord-001397-nrq4ncdf 304 16 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 304 17 ( ( -LRB- cord-001397-nrq4ncdf 304 18 Gould Gould NNP cord-001397-nrq4ncdf 304 19 , , , cord-001397-nrq4ncdf 304 20 2001 2001 CD cord-001397-nrq4ncdf 304 21 ) ) -RRB- cord-001397-nrq4ncdf 304 22 . . . cord-001397-nrq4ncdf 305 1 Diverse diverse JJ cord-001397-nrq4ncdf 305 2 mosquito mosquito NN cord-001397-nrq4ncdf 305 3 species specie NNS cord-001397-nrq4ncdf 305 4 can can MD cord-001397-nrq4ncdf 305 5 be be VB cord-001397-nrq4ncdf 305 6 infected infect VBN cord-001397-nrq4ncdf 305 7 by by IN cord-001397-nrq4ncdf 305 8 MBFVs mbfv NNS cord-001397-nrq4ncdf 305 9 . . . cord-001397-nrq4ncdf 306 1 However however RB cord-001397-nrq4ncdf 306 2 , , , cord-001397-nrq4ncdf 306 3 the the DT cord-001397-nrq4ncdf 306 4 two two CD cord-001397-nrq4ncdf 306 5 major major JJ cord-001397-nrq4ncdf 306 6 mosquito mosquito NN cord-001397-nrq4ncdf 306 7 vectors vector NNS cord-001397-nrq4ncdf 306 8 are be VBP cord-001397-nrq4ncdf 306 9 Aedes Aedes NNP cord-001397-nrq4ncdf 306 10 aegypti aegypti NNS cord-001397-nrq4ncdf 306 11 ( ( -LRB- cord-001397-nrq4ncdf 306 12 e.g. e.g. JJ cord-001397-nrq4ncdf 306 13 transmission transmission NN cord-001397-nrq4ncdf 306 14 of of IN cord-001397-nrq4ncdf 306 15 YFV YFV NNP cord-001397-nrq4ncdf 306 16 and and CC cord-001397-nrq4ncdf 306 17 DENV DENV NNP cord-001397-nrq4ncdf 306 18 ) ) -RRB- cord-001397-nrq4ncdf 306 19 and and CC cord-001397-nrq4ncdf 306 20 Culex Culex NNP cord-001397-nrq4ncdf 306 21 species specie NNS cord-001397-nrq4ncdf 306 22 ( ( -LRB- cord-001397-nrq4ncdf 306 23 e.g. e.g. JJ cord-001397-nrq4ncdf 306 24 transmission transmission NN cord-001397-nrq4ncdf 306 25 of of IN cord-001397-nrq4ncdf 306 26 WNV WNV NNP cord-001397-nrq4ncdf 306 27 and and CC cord-001397-nrq4ncdf 306 28 JEV JEV NNP cord-001397-nrq4ncdf 306 29 ) ) -RRB- cord-001397-nrq4ncdf 306 30 . . . cord-001397-nrq4ncdf 307 1 Adult adult JJ cord-001397-nrq4ncdf 307 2 female female JJ cord-001397-nrq4ncdf 307 3 mosquitoes mosquito NNS cord-001397-nrq4ncdf 307 4 become become VBP cord-001397-nrq4ncdf 307 5 infected infected JJ cord-001397-nrq4ncdf 307 6 when when WRB cord-001397-nrq4ncdf 307 7 they -PRON- PRP cord-001397-nrq4ncdf 307 8 obtain obtain VBP cord-001397-nrq4ncdf 307 9 blood blood NN cord-001397-nrq4ncdf 307 10 meals meal NNS cord-001397-nrq4ncdf 307 11 from from IN cord-001397-nrq4ncdf 307 12 flavivirus flavivirus JJ cord-001397-nrq4ncdf 307 13 - - HYPH cord-001397-nrq4ncdf 307 14 infected infect VBN cord-001397-nrq4ncdf 307 15 animals animal NNS cord-001397-nrq4ncdf 307 16 , , , cord-001397-nrq4ncdf 307 17 and and CC cord-001397-nrq4ncdf 307 18 virus virus NN cord-001397-nrq4ncdf 307 19 replication replication NN cord-001397-nrq4ncdf 307 20 in in IN cord-001397-nrq4ncdf 307 21 the the DT cord-001397-nrq4ncdf 307 22 mosquito mosquito NN cord-001397-nrq4ncdf 307 23 has have VBZ cord-001397-nrq4ncdf 307 24 been be VBN cord-001397-nrq4ncdf 307 25 well well RB cord-001397-nrq4ncdf 307 26 described describe VBN cord-001397-nrq4ncdf 307 27 ( ( -LRB- cord-001397-nrq4ncdf 307 28 Girard Girard NNP cord-001397-nrq4ncdf 307 29 et et NNP cord-001397-nrq4ncdf 307 30 al al NNP cord-001397-nrq4ncdf 307 31 . . NNP cord-001397-nrq4ncdf 307 32 , , , cord-001397-nrq4ncdf 307 33 2005 2005 CD cord-001397-nrq4ncdf 307 34 ; ; : cord-001397-nrq4ncdf 308 1 McGee McGee NNP cord-001397-nrq4ncdf 308 2 et et NNP cord-001397-nrq4ncdf 308 3 al al NNP cord-001397-nrq4ncdf 308 4 . . NNP cord-001397-nrq4ncdf 308 5 , , , cord-001397-nrq4ncdf 308 6 2010 2010 CD cord-001397-nrq4ncdf 308 7 ; ; : cord-001397-nrq4ncdf 308 8 Colpitts Colpitts NNP cord-001397-nrq4ncdf 308 9 et et NNP cord-001397-nrq4ncdf 308 10 al al NNP cord-001397-nrq4ncdf 308 11 . . NNP cord-001397-nrq4ncdf 308 12 , , , cord-001397-nrq4ncdf 308 13 2012 2012 CD cord-001397-nrq4ncdf 308 14 ) ) -RRB- cord-001397-nrq4ncdf 308 15 . . . cord-001397-nrq4ncdf 309 1 Girard Girard NNP cord-001397-nrq4ncdf 309 2 et et NNP cord-001397-nrq4ncdf 309 3 al al NNP cord-001397-nrq4ncdf 309 4 . . . cord-001397-nrq4ncdf 310 1 ( ( -LRB- cord-001397-nrq4ncdf 310 2 2004 2004 CD cord-001397-nrq4ncdf 310 3 ) ) -RRB- cord-001397-nrq4ncdf 310 4 used use VBN cord-001397-nrq4ncdf 310 5 immunohistochemistry immunohistochemistry NN cord-001397-nrq4ncdf 310 6 to to TO cord-001397-nrq4ncdf 310 7 demonstrate demonstrate VB cord-001397-nrq4ncdf 310 8 that that IN cord-001397-nrq4ncdf 310 9 WNV WNV NNP cord-001397-nrq4ncdf 310 10 infects infect VBZ cord-001397-nrq4ncdf 310 11 epithelial epithelial JJ cord-001397-nrq4ncdf 310 12 cells cell NNS cord-001397-nrq4ncdf 310 13 of of IN cord-001397-nrq4ncdf 310 14 the the DT cord-001397-nrq4ncdf 310 15 Culex Culex NNP cord-001397-nrq4ncdf 310 16 pipiens pipien VBZ cord-001397-nrq4ncdf 310 17 midgut midgut NN cord-001397-nrq4ncdf 310 18 and and CC cord-001397-nrq4ncdf 310 19 that that IN cord-001397-nrq4ncdf 310 20 viral viral JJ cord-001397-nrq4ncdf 310 21 antigen antigen NN cord-001397-nrq4ncdf 310 22 can can MD cord-001397-nrq4ncdf 310 23 be be VB cord-001397-nrq4ncdf 310 24 detected detect VBN cord-001397-nrq4ncdf 310 25 as as RB cord-001397-nrq4ncdf 310 26 early early RB cord-001397-nrq4ncdf 310 27 as as IN cord-001397-nrq4ncdf 310 28 day day NN cord-001397-nrq4ncdf 310 29 2 2 CD cord-001397-nrq4ncdf 310 30 postinfection postinfection NN cord-001397-nrq4ncdf 310 31 . . . cord-001397-nrq4ncdf 311 1 Viral viral JJ cord-001397-nrq4ncdf 311 2 antigen antigen NN cord-001397-nrq4ncdf 311 3 staining staining NN cord-001397-nrq4ncdf 311 4 becomes become VBZ cord-001397-nrq4ncdf 311 5 more more RBR cord-001397-nrq4ncdf 311 6 intense intense JJ cord-001397-nrq4ncdf 311 7 in in IN cord-001397-nrq4ncdf 311 8 the the DT cord-001397-nrq4ncdf 311 9 cells cell NNS cord-001397-nrq4ncdf 311 10 of of IN cord-001397-nrq4ncdf 311 11 the the DT cord-001397-nrq4ncdf 311 12 midgut midgut NN cord-001397-nrq4ncdf 311 13 over over IN cord-001397-nrq4ncdf 311 14 time time NN cord-001397-nrq4ncdf 311 15 until until IN cord-001397-nrq4ncdf 311 16 day day NN cord-001397-nrq4ncdf 311 17 14 14 CD cord-001397-nrq4ncdf 311 18 to to TO cord-001397-nrq4ncdf 311 19 21 21 CD cord-001397-nrq4ncdf 311 20 following follow VBG cord-001397-nrq4ncdf 311 21 infection infection NN cord-001397-nrq4ncdf 312 1 ( ( -LRB- cord-001397-nrq4ncdf 312 2 Girard Girard NNP cord-001397-nrq4ncdf 312 3 et et NNP cord-001397-nrq4ncdf 312 4 al al NNP cord-001397-nrq4ncdf 312 5 . . NNP cord-001397-nrq4ncdf 312 6 , , , cord-001397-nrq4ncdf 312 7 2004 2004 CD cord-001397-nrq4ncdf 312 8 ) ) -RRB- cord-001397-nrq4ncdf 312 9 . . . cord-001397-nrq4ncdf 313 1 Using use VBG cord-001397-nrq4ncdf 313 2 DENV-2 DENV-2 NNP cord-001397-nrq4ncdf 313 3 , , , cord-001397-nrq4ncdf 313 4 virus virus NN cord-001397-nrq4ncdf 313 5 titer titer NN cord-001397-nrq4ncdf 313 6 in in IN cord-001397-nrq4ncdf 313 7 the the DT cord-001397-nrq4ncdf 313 8 midgut midgut NN cord-001397-nrq4ncdf 313 9 peaks peak NNS cord-001397-nrq4ncdf 313 10 to to IN cord-001397-nrq4ncdf 313 11 about about RB cord-001397-nrq4ncdf 313 12 9 9 CD cord-001397-nrq4ncdf 313 13 9 9 CD cord-001397-nrq4ncdf 313 14 10 10 CD cord-001397-nrq4ncdf 313 15 3 3 CD cord-001397-nrq4ncdf 313 16 pfu pfu NN cord-001397-nrq4ncdf 313 17 mL ml NN cord-001397-nrq4ncdf 313 18 À1 à1 NN cord-001397-nrq4ncdf 313 19 by by IN cord-001397-nrq4ncdf 313 20 10 10 CD cord-001397-nrq4ncdf 313 21 days day NNS cord-001397-nrq4ncdf 313 22 postinfection postinfection NN cord-001397-nrq4ncdf 313 23 , , , cord-001397-nrq4ncdf 313 24 but but CC cord-001397-nrq4ncdf 313 25 declines decline VBZ cord-001397-nrq4ncdf 313 26 to to IN cord-001397-nrq4ncdf 313 27 about about RB cord-001397-nrq4ncdf 313 28 7.4 7.4 CD cord-001397-nrq4ncdf 313 29 9 9 CD cord-001397-nrq4ncdf 313 30 10 10 CD cord-001397-nrq4ncdf 313 31 2 2 CD cord-001397-nrq4ncdf 313 32 pfu pfu NN cord-001397-nrq4ncdf 313 33 mL ml NN cord-001397-nrq4ncdf 313 34 À1 À1 NNP cord-001397-nrq4ncdf 313 35 by by IN cord-001397-nrq4ncdf 313 36 day day NN cord-001397-nrq4ncdf 313 37 12 12 CD cord-001397-nrq4ncdf 314 1 ( ( -LRB- cord-001397-nrq4ncdf 314 2 S S NNP cord-001397-nrq4ncdf 314 3 anchez- anchez- NN cord-001397-nrq4ncdf 314 4 Vargas Vargas NNP cord-001397-nrq4ncdf 314 5 et et NNP cord-001397-nrq4ncdf 314 6 al al NNP cord-001397-nrq4ncdf 314 7 . . NNP cord-001397-nrq4ncdf 314 8 , , , cord-001397-nrq4ncdf 314 9 2009 2009 CD cord-001397-nrq4ncdf 314 10 ) ) -RRB- cord-001397-nrq4ncdf 314 11 . . . cord-001397-nrq4ncdf 315 1 Dissemination dissemination NN cord-001397-nrq4ncdf 315 2 of of IN cord-001397-nrq4ncdf 315 3 virus virus NN cord-001397-nrq4ncdf 315 4 into into IN cord-001397-nrq4ncdf 315 5 various various JJ cord-001397-nrq4ncdf 315 6 tissues tissue NNS cord-001397-nrq4ncdf 315 7 occurs occur VBZ cord-001397-nrq4ncdf 315 8 at at IN cord-001397-nrq4ncdf 315 9 various various JJ cord-001397-nrq4ncdf 315 10 time time NN cord-001397-nrq4ncdf 315 11 points point NNS cord-001397-nrq4ncdf 315 12 , , , cord-001397-nrq4ncdf 315 13 and and CC cord-001397-nrq4ncdf 315 14 the the DT cord-001397-nrq4ncdf 315 15 amount amount NN cord-001397-nrq4ncdf 315 16 of of IN cord-001397-nrq4ncdf 315 17 antigen antigen NN cord-001397-nrq4ncdf 315 18 also also RB cord-001397-nrq4ncdf 315 19 varies vary VBZ cord-001397-nrq4ncdf 315 20 . . . cord-001397-nrq4ncdf 316 1 Similar similar JJ cord-001397-nrq4ncdf 316 2 to to IN cord-001397-nrq4ncdf 316 3 TBFVs tbfvs VB cord-001397-nrq4ncdf 316 4 in in IN cord-001397-nrq4ncdf 316 5 ticks tick NNS cord-001397-nrq4ncdf 316 6 , , , cord-001397-nrq4ncdf 316 7 the the DT cord-001397-nrq4ncdf 316 8 hemolymph hemolymph NN cord-001397-nrq4ncdf 316 9 serves serve VBZ cord-001397-nrq4ncdf 316 10 as as IN cord-001397-nrq4ncdf 316 11 a a DT cord-001397-nrq4ncdf 316 12 vehicle vehicle NN cord-001397-nrq4ncdf 316 13 for for IN cord-001397-nrq4ncdf 316 14 viral viral JJ cord-001397-nrq4ncdf 316 15 dissemination dissemination NN cord-001397-nrq4ncdf 316 16 . . . cord-001397-nrq4ncdf 317 1 However however RB cord-001397-nrq4ncdf 317 2 , , , cord-001397-nrq4ncdf 317 3 virus virus NN cord-001397-nrq4ncdf 317 4 also also RB cord-001397-nrq4ncdf 317 5 spreads spread VBZ cord-001397-nrq4ncdf 317 6 in in IN cord-001397-nrq4ncdf 317 7 a a DT cord-001397-nrq4ncdf 317 8 cell cell NN cord-001397-nrq4ncdf 317 9 - - HYPH cord-001397-nrq4ncdf 317 10 cell cell NN cord-001397-nrq4ncdf 317 11 fashion fashion NN cord-001397-nrq4ncdf 317 12 to to IN cord-001397-nrq4ncdf 317 13 the the DT cord-001397-nrq4ncdf 317 14 muscle muscle NN cord-001397-nrq4ncdf 317 15 of of IN cord-001397-nrq4ncdf 317 16 the the DT cord-001397-nrq4ncdf 317 17 posterior posterior JJ cord-001397-nrq4ncdf 317 18 midgut midgut NN cord-001397-nrq4ncdf 317 19 from from IN cord-001397-nrq4ncdf 317 20 6 6 CD cord-001397-nrq4ncdf 317 21 to to TO cord-001397-nrq4ncdf 317 22 27 27 CD cord-001397-nrq4ncdf 317 23 days day NNS cord-001397-nrq4ncdf 317 24 postinfection postinfection NN cord-001397-nrq4ncdf 317 25 ( ( -LRB- cord-001397-nrq4ncdf 317 26 Girard Girard NNP cord-001397-nrq4ncdf 317 27 et et NNP cord-001397-nrq4ncdf 317 28 al al NNP cord-001397-nrq4ncdf 317 29 . . NNP cord-001397-nrq4ncdf 317 30 , , , cord-001397-nrq4ncdf 317 31 2004 2004 CD cord-001397-nrq4ncdf 317 32 ) ) -RRB- cord-001397-nrq4ncdf 317 33 . . . cord-001397-nrq4ncdf 318 1 Studies study NNS cord-001397-nrq4ncdf 318 2 with with IN cord-001397-nrq4ncdf 318 3 DENV-2 DENV-2 NNP cord-001397-nrq4ncdf 318 4 showed show VBD cord-001397-nrq4ncdf 318 5 that that IN cord-001397-nrq4ncdf 318 6 infected infected JJ cord-001397-nrq4ncdf 318 7 mosquitoes mosquito NNS cord-001397-nrq4ncdf 318 8 mount mount VBP cord-001397-nrq4ncdf 318 9 an an DT cord-001397-nrq4ncdf 318 10 RNA RNA NNP cord-001397-nrq4ncdf 318 11 interference interference NN cord-001397-nrq4ncdf 318 12 ( ( -LRB- cord-001397-nrq4ncdf 318 13 RNAi)-mediated rnai)-mediated JJ cord-001397-nrq4ncdf 318 14 antiviral antiviral JJ cord-001397-nrq4ncdf 318 15 response response NN cord-001397-nrq4ncdf 318 16 , , , cord-001397-nrq4ncdf 318 17 but but CC cord-001397-nrq4ncdf 318 18 impairing impair VBG cord-001397-nrq4ncdf 318 19 the the DT cord-001397-nrq4ncdf 318 20 vector vector NN cord-001397-nrq4ncdf 318 21 RNAi RNAi NNS cord-001397-nrq4ncdf 318 22 resulted result VBD cord-001397-nrq4ncdf 318 23 in in IN cord-001397-nrq4ncdf 318 24 increased increase VBN cord-001397-nrq4ncdf 318 25 viral viral JJ cord-001397-nrq4ncdf 318 26 replication replication NN cord-001397-nrq4ncdf 318 27 ( ( -LRB- cord-001397-nrq4ncdf 318 28 S S NNP cord-001397-nrq4ncdf 318 29 anchez- anchez- NN cord-001397-nrq4ncdf 318 30 Vargas Vargas NNP cord-001397-nrq4ncdf 318 31 et et NNP cord-001397-nrq4ncdf 318 32 al al NNP cord-001397-nrq4ncdf 318 33 . . NNP cord-001397-nrq4ncdf 318 34 , , , cord-001397-nrq4ncdf 318 35 2009 2009 CD cord-001397-nrq4ncdf 318 36 ) ) -RRB- cord-001397-nrq4ncdf 318 37 . . . cord-001397-nrq4ncdf 319 1 This this DT cord-001397-nrq4ncdf 319 2 mechanism mechanism NN cord-001397-nrq4ncdf 319 3 could could MD cord-001397-nrq4ncdf 319 4 be be VB cord-001397-nrq4ncdf 319 5 associated associate VBN cord-001397-nrq4ncdf 319 6 with with IN cord-001397-nrq4ncdf 319 7 observations observation NNS cord-001397-nrq4ncdf 319 8 of of IN cord-001397-nrq4ncdf 319 9 flavivirus flavivirus JJ cord-001397-nrq4ncdf 319 10 - - HYPH cord-001397-nrq4ncdf 319 11 related relate VBN cord-001397-nrq4ncdf 319 12 RNA RNA NNP cord-001397-nrq4ncdf 319 13 that that WDT cord-001397-nrq4ncdf 319 14 persists persist VBZ cord-001397-nrq4ncdf 319 15 as as IN cord-001397-nrq4ncdf 319 16 DNA dna NN cord-001397-nrq4ncdf 319 17 in in IN cord-001397-nrq4ncdf 319 18 mosquitoes mosquito NNS cord-001397-nrq4ncdf 320 1 ( ( -LRB- cord-001397-nrq4ncdf 320 2 Crochu Crochu NNP cord-001397-nrq4ncdf 320 3 et et NNP cord-001397-nrq4ncdf 320 4 al al NNP cord-001397-nrq4ncdf 320 5 . . NNP cord-001397-nrq4ncdf 320 6 , , , cord-001397-nrq4ncdf 320 7 2004 2004 CD cord-001397-nrq4ncdf 320 8 ) ) -RRB- cord-001397-nrq4ncdf 320 9 . . . cord-001397-nrq4ncdf 321 1 As as IN cord-001397-nrq4ncdf 321 2 mosquitoes mosquito NNS cord-001397-nrq4ncdf 321 3 are be VBP cord-001397-nrq4ncdf 321 4 such such JJ cord-001397-nrq4ncdf 321 5 efficient efficient JJ cord-001397-nrq4ncdf 321 6 vectors vector NNS cord-001397-nrq4ncdf 321 7 for for IN cord-001397-nrq4ncdf 321 8 the the DT cord-001397-nrq4ncdf 321 9 transmission transmission NN cord-001397-nrq4ncdf 321 10 of of IN cord-001397-nrq4ncdf 321 11 the the DT cord-001397-nrq4ncdf 321 12 MBFVs mbfv NNS cord-001397-nrq4ncdf 321 13 , , , cord-001397-nrq4ncdf 321 14 these these DT cord-001397-nrq4ncdf 321 15 reports report NNS cord-001397-nrq4ncdf 321 16 suggest suggest VBP cord-001397-nrq4ncdf 321 17 that that IN cord-001397-nrq4ncdf 321 18 the the DT cord-001397-nrq4ncdf 321 19 viruses virus NNS cord-001397-nrq4ncdf 321 20 have have VBP cord-001397-nrq4ncdf 321 21 evolved evolve VBN cord-001397-nrq4ncdf 321 22 a a DT cord-001397-nrq4ncdf 321 23 mechanism mechanism NN cord-001397-nrq4ncdf 321 24 of of IN cord-001397-nrq4ncdf 321 25 evading evade VBG cord-001397-nrq4ncdf 321 26 the the DT cord-001397-nrq4ncdf 321 27 host host NN cord-001397-nrq4ncdf 321 28 response response NN cord-001397-nrq4ncdf 321 29 to to TO cord-001397-nrq4ncdf 321 30 persist persist VB cord-001397-nrq4ncdf 321 31 in in IN cord-001397-nrq4ncdf 321 32 the the DT cord-001397-nrq4ncdf 321 33 vector vector NN cord-001397-nrq4ncdf 321 34 . . . cord-001397-nrq4ncdf 322 1 Mosquitoes mosquito NNS cord-001397-nrq4ncdf 322 2 also also RB cord-001397-nrq4ncdf 322 3 acquire acquire VBP cord-001397-nrq4ncdf 322 4 and and CC cord-001397-nrq4ncdf 322 5 deliver deliver VB cord-001397-nrq4ncdf 322 6 virus virus NN cord-001397-nrq4ncdf 322 7 horizontally horizontally RB cord-001397-nrq4ncdf 322 8 during during IN cord-001397-nrq4ncdf 322 9 blood blood NN cord-001397-nrq4ncdf 322 10 meals meal NNS cord-001397-nrq4ncdf 322 11 and and CC cord-001397-nrq4ncdf 322 12 are be VBP cord-001397-nrq4ncdf 322 13 competent competent JJ cord-001397-nrq4ncdf 322 14 to to TO cord-001397-nrq4ncdf 322 15 transmit transmit VB cord-001397-nrq4ncdf 322 16 vertically vertically RB cord-001397-nrq4ncdf 322 17 to to TO cord-001397-nrq4ncdf 322 18 progeny progeny VB cord-001397-nrq4ncdf 322 19 by by IN cord-001397-nrq4ncdf 322 20 transovarial transovarial JJ cord-001397-nrq4ncdf 322 21 passage passage NN cord-001397-nrq4ncdf 323 1 ( ( -LRB- cord-001397-nrq4ncdf 323 2 Rosen Rosen NNP cord-001397-nrq4ncdf 323 3 et et NNP cord-001397-nrq4ncdf 323 4 al al NNP cord-001397-nrq4ncdf 323 5 . . NNP cord-001397-nrq4ncdf 323 6 , , , cord-001397-nrq4ncdf 323 7 1983 1983 CD cord-001397-nrq4ncdf 323 8 ) ) -RRB- cord-001397-nrq4ncdf 323 9 . . . cord-001397-nrq4ncdf 324 1 WNV WNV NNP cord-001397-nrq4ncdf 324 2 can can MD cord-001397-nrq4ncdf 324 3 persist persist VB cord-001397-nrq4ncdf 324 4 overwinter overwinter VB cord-001397-nrq4ncdf 324 5 in in IN cord-001397-nrq4ncdf 324 6 mosquitoes mosquito NNS cord-001397-nrq4ncdf 324 7 that that WDT cord-001397-nrq4ncdf 324 8 hibernate hibernate VBP cord-001397-nrq4ncdf 324 9 in in IN cord-001397-nrq4ncdf 324 10 cold cold JJ cord-001397-nrq4ncdf 324 11 months month NNS cord-001397-nrq4ncdf 324 12 . . . cord-001397-nrq4ncdf 325 1 Cool cool JJ cord-001397-nrq4ncdf 325 2 temperatures temperature NNS cord-001397-nrq4ncdf 325 3 also also RB cord-001397-nrq4ncdf 325 4 facilitate facilitate VBP cord-001397-nrq4ncdf 325 5 persistence persistence NN cord-001397-nrq4ncdf 325 6 of of IN cord-001397-nrq4ncdf 325 7 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 325 8 in in IN cord-001397-nrq4ncdf 325 9 adult adult NN cord-001397-nrq4ncdf 325 10 female female JJ cord-001397-nrq4ncdf 325 11 mosquitoes mosquito NNS cord-001397-nrq4ncdf 325 12 . . . cord-001397-nrq4ncdf 326 1 For for IN cord-001397-nrq4ncdf 326 2 example example NN cord-001397-nrq4ncdf 326 3 , , , cord-001397-nrq4ncdf 326 4 St. St. NNP cord-001397-nrq4ncdf 326 5 Louis Louis NNP cord-001397-nrq4ncdf 326 6 encephalitis encephalitis NN cord-001397-nrq4ncdf 326 7 virus virus NN cord-001397-nrq4ncdf 326 8 ( ( -LRB- cord-001397-nrq4ncdf 326 9 SLEV SLEV NNP cord-001397-nrq4ncdf 326 10 ) ) -RRB- cord-001397-nrq4ncdf 326 11 survived survive VBD cord-001397-nrq4ncdf 326 12 for for IN cord-001397-nrq4ncdf 326 13 more more JJR cord-001397-nrq4ncdf 326 14 than than IN cord-001397-nrq4ncdf 326 15 100 100 CD cord-001397-nrq4ncdf 326 16 days day NNS cord-001397-nrq4ncdf 326 17 of of IN cord-001397-nrq4ncdf 326 18 winter winter NN cord-001397-nrq4ncdf 326 19 in in IN cord-001397-nrq4ncdf 326 20 Culex Culex NNP cord-001397-nrq4ncdf 326 21 quinquefasciatus quinquefasciatus NNP cord-001397-nrq4ncdf 326 22 ( ( -LRB- cord-001397-nrq4ncdf 326 23 Kramer Kramer NNP cord-001397-nrq4ncdf 326 24 & & CC cord-001397-nrq4ncdf 326 25 Ebel Ebel NNP cord-001397-nrq4ncdf 326 26 , , , cord-001397-nrq4ncdf 326 27 2003 2003 CD cord-001397-nrq4ncdf 326 28 ) ) -RRB- cord-001397-nrq4ncdf 326 29 . . . cord-001397-nrq4ncdf 327 1 Similarly similarly RB cord-001397-nrq4ncdf 327 2 , , , cord-001397-nrq4ncdf 327 3 JEV JEV NNP cord-001397-nrq4ncdf 327 4 and and CC cord-001397-nrq4ncdf 327 5 WNV WNV NNP cord-001397-nrq4ncdf 327 6 have have VBP cord-001397-nrq4ncdf 327 7 been be VBN cord-001397-nrq4ncdf 327 8 transmitted transmit VBN cord-001397-nrq4ncdf 327 9 by by IN cord-001397-nrq4ncdf 327 10 mosquitoes mosquito NNS cord-001397-nrq4ncdf 327 11 that that WDT cord-001397-nrq4ncdf 327 12 carried carry VBD cord-001397-nrq4ncdf 327 13 the the DT cord-001397-nrq4ncdf 327 14 viruses virus NNS cord-001397-nrq4ncdf 327 15 at at IN cord-001397-nrq4ncdf 327 16 cold cold JJ cord-001397-nrq4ncdf 327 17 temperatures temperature NNS cord-001397-nrq4ncdf 327 18 when when WRB cord-001397-nrq4ncdf 327 19 exposed expose VBN cord-001397-nrq4ncdf 327 20 to to IN cord-001397-nrq4ncdf 327 21 temperature temperature NN cord-001397-nrq4ncdf 327 22 increases increase NNS cord-001397-nrq4ncdf 327 23 equal equal JJ cord-001397-nrq4ncdf 327 24 to to IN cord-001397-nrq4ncdf 327 25 ambient ambient JJ cord-001397-nrq4ncdf 327 26 levels level NNS cord-001397-nrq4ncdf 327 27 ( ( -LRB- cord-001397-nrq4ncdf 327 28 Kramer Kramer NNP cord-001397-nrq4ncdf 327 29 & & CC cord-001397-nrq4ncdf 327 30 Ebel Ebel NNP cord-001397-nrq4ncdf 327 31 , , , cord-001397-nrq4ncdf 327 32 2003 2003 CD cord-001397-nrq4ncdf 327 33 ) ) -RRB- cord-001397-nrq4ncdf 327 34 . . . cord-001397-nrq4ncdf 328 1 However however RB cord-001397-nrq4ncdf 328 2 , , , cord-001397-nrq4ncdf 328 3 at at IN cord-001397-nrq4ncdf 328 4 low low JJ cord-001397-nrq4ncdf 328 5 temperature temperature NN cord-001397-nrq4ncdf 328 6 , , , cord-001397-nrq4ncdf 328 7 mosquitoes mosquito NNS cord-001397-nrq4ncdf 328 8 are be VBP cord-001397-nrq4ncdf 328 9 less less RBR cord-001397-nrq4ncdf 328 10 likely likely JJ cord-001397-nrq4ncdf 328 11 to to TO cord-001397-nrq4ncdf 328 12 acquire acquire VB cord-001397-nrq4ncdf 328 13 new new JJ cord-001397-nrq4ncdf 328 14 infections infection NNS cord-001397-nrq4ncdf 328 15 ( ( -LRB- cord-001397-nrq4ncdf 328 16 Colpitts Colpitts NNP cord-001397-nrq4ncdf 328 17 et et NNP cord-001397-nrq4ncdf 328 18 al al NNP cord-001397-nrq4ncdf 328 19 . . NNP cord-001397-nrq4ncdf 328 20 , , , cord-001397-nrq4ncdf 328 21 2012 2012 CD cord-001397-nrq4ncdf 328 22 ) ) -RRB- cord-001397-nrq4ncdf 328 23 . . . cord-001397-nrq4ncdf 329 1 At at IN cord-001397-nrq4ncdf 329 2 18 18 CD cord-001397-nrq4ncdf 329 3 ° ° NN cord-001397-nrq4ncdf 329 4 C c NN cord-001397-nrq4ncdf 329 5 , , , cord-001397-nrq4ncdf 329 6 low low JJ cord-001397-nrq4ncdf 329 7 WNV WNV NNP cord-001397-nrq4ncdf 329 8 dissemination dissemination NN cord-001397-nrq4ncdf 329 9 to to IN cord-001397-nrq4ncdf 329 10 the the DT cord-001397-nrq4ncdf 329 11 legs leg NNS cord-001397-nrq4ncdf 329 12 of of IN cord-001397-nrq4ncdf 329 13 the the DT cord-001397-nrq4ncdf 329 14 C. C. NNP cord-001397-nrq4ncdf 329 15 pipiens pipien NNS cord-001397-nrq4ncdf 329 16 was be VBD cord-001397-nrq4ncdf 329 17 observed observe VBN cord-001397-nrq4ncdf 329 18 , , , cord-001397-nrq4ncdf 329 19 and and CC cord-001397-nrq4ncdf 329 20 rapid rapid JJ cord-001397-nrq4ncdf 329 21 viral viral JJ cord-001397-nrq4ncdf 329 22 dissemination dissemination NN cord-001397-nrq4ncdf 329 23 occurred occur VBD cord-001397-nrq4ncdf 329 24 at at IN cord-001397-nrq4ncdf 329 25 higher high JJR cord-001397-nrq4ncdf 329 26 temperatures temperature NNS cord-001397-nrq4ncdf 329 27 ( ( -LRB- cord-001397-nrq4ncdf 329 28 Colpitts Colpitts NNP cord-001397-nrq4ncdf 329 29 et et NNP cord-001397-nrq4ncdf 329 30 al al NNP cord-001397-nrq4ncdf 329 31 . . NNP cord-001397-nrq4ncdf 329 32 , , , cord-001397-nrq4ncdf 329 33 2012 2012 CD cord-001397-nrq4ncdf 329 34 ) ) -RRB- cord-001397-nrq4ncdf 329 35 . . . cord-001397-nrq4ncdf 330 1 Furthermore furthermore RB cord-001397-nrq4ncdf 330 2 , , , cord-001397-nrq4ncdf 330 3 higher high JJR cord-001397-nrq4ncdf 330 4 temperatures temperature NNS cord-001397-nrq4ncdf 330 5 increase increase VBP cord-001397-nrq4ncdf 330 6 vector vector NN cord-001397-nrq4ncdf 330 7 population population NN cord-001397-nrq4ncdf 330 8 growth growth NN cord-001397-nrq4ncdf 330 9 rate rate NN cord-001397-nrq4ncdf 330 10 and and CC cord-001397-nrq4ncdf 330 11 the the DT cord-001397-nrq4ncdf 330 12 rate rate NN cord-001397-nrq4ncdf 330 13 of of IN cord-001397-nrq4ncdf 330 14 viral viral JJ cord-001397-nrq4ncdf 330 15 evolution evolution NN cord-001397-nrq4ncdf 330 16 in in IN cord-001397-nrq4ncdf 330 17 the the DT cord-001397-nrq4ncdf 330 18 mosquito mosquito NN cord-001397-nrq4ncdf 330 19 ( ( -LRB- cord-001397-nrq4ncdf 330 20 Girard Girard NNP cord-001397-nrq4ncdf 330 21 et et NNP cord-001397-nrq4ncdf 330 22 al al NNP cord-001397-nrq4ncdf 330 23 . . NNP cord-001397-nrq4ncdf 330 24 , , , cord-001397-nrq4ncdf 330 25 2005 2005 CD cord-001397-nrq4ncdf 330 26 ) ) -RRB- cord-001397-nrq4ncdf 330 27 . . . cord-001397-nrq4ncdf 331 1 The the DT cord-001397-nrq4ncdf 331 2 prevalence prevalence NN cord-001397-nrq4ncdf 331 3 and and CC cord-001397-nrq4ncdf 331 4 maintenance maintenance NN cord-001397-nrq4ncdf 331 5 of of IN cord-001397-nrq4ncdf 331 6 WNV WNV NNP cord-001397-nrq4ncdf 331 7 across across IN cord-001397-nrq4ncdf 331 8 landscapes landscape NNS cord-001397-nrq4ncdf 331 9 is be VBZ cord-001397-nrq4ncdf 331 10 mediated mediate VBN cord-001397-nrq4ncdf 331 11 by by IN cord-001397-nrq4ncdf 331 12 environmental environmental JJ cord-001397-nrq4ncdf 331 13 factors factor NNS cord-001397-nrq4ncdf 331 14 , , , cord-001397-nrq4ncdf 331 15 such such JJ cord-001397-nrq4ncdf 331 16 as as IN cord-001397-nrq4ncdf 331 17 local local JJ cord-001397-nrq4ncdf 331 18 effects effect NNS cord-001397-nrq4ncdf 331 19 of of IN cord-001397-nrq4ncdf 331 20 agriculture agriculture NN cord-001397-nrq4ncdf 331 21 on on IN cord-001397-nrq4ncdf 331 22 vector vector NN cord-001397-nrq4ncdf 331 23 and and CC cord-001397-nrq4ncdf 331 24 host host NN cord-001397-nrq4ncdf 331 25 communities community NNS cord-001397-nrq4ncdf 331 26 ( ( -LRB- cord-001397-nrq4ncdf 332 1 Crowder Crowder NNP cord-001397-nrq4ncdf 332 2 et et NNP cord-001397-nrq4ncdf 332 3 al al NNP cord-001397-nrq4ncdf 332 4 . . . cord-001397-nrq4ncdf 333 1 , , , cord-001397-nrq4ncdf 333 2 2013 2013 CD cord-001397-nrq4ncdf 333 3 ) ) -RRB- cord-001397-nrq4ncdf 333 4 . . . cord-001397-nrq4ncdf 334 1 Results result NNS cord-001397-nrq4ncdf 334 2 of of IN cord-001397-nrq4ncdf 334 3 investigations investigation NNS cord-001397-nrq4ncdf 334 4 carried carry VBN cord-001397-nrq4ncdf 334 5 out out RP cord-001397-nrq4ncdf 334 6 in in IN cord-001397-nrq4ncdf 334 7 the the DT cord-001397-nrq4ncdf 334 8 states state NNS cord-001397-nrq4ncdf 334 9 of of IN cord-001397-nrq4ncdf 334 10 Oregon Oregon NNP cord-001397-nrq4ncdf 334 11 and and CC cord-001397-nrq4ncdf 334 12 Washington Washington NNP cord-001397-nrq4ncdf 334 13 showed show VBD cord-001397-nrq4ncdf 334 14 that that IN cord-001397-nrq4ncdf 334 15 the the DT cord-001397-nrq4ncdf 334 16 prevalence prevalence NN cord-001397-nrq4ncdf 334 17 of of IN cord-001397-nrq4ncdf 334 18 WNV WNV NNP cord-001397-nrq4ncdf 334 19 in in IN cord-001397-nrq4ncdf 334 20 both both CC cord-001397-nrq4ncdf 334 21 C. C. NNP cord-001397-nrq4ncdf 334 22 pipiens pipien NNS cord-001397-nrq4ncdf 334 23 and and CC cord-001397-nrq4ncdf 334 24 Culex Culex NNP cord-001397-nrq4ncdf 334 25 tarsalis tarsalis NNP cord-001397-nrq4ncdf 334 26 was be VBD cord-001397-nrq4ncdf 334 27 similar similar JJ cord-001397-nrq4ncdf 334 28 at at IN cord-001397-nrq4ncdf 334 29 14.5 14.5 CD cord-001397-nrq4ncdf 334 30 % % NN cord-001397-nrq4ncdf 334 31 or or CC cord-001397-nrq4ncdf 334 32 13.5 13.5 CD cord-001397-nrq4ncdf 334 33 % % NN cord-001397-nrq4ncdf 334 34 , , , cord-001397-nrq4ncdf 334 35 respectively respectively RB cord-001397-nrq4ncdf 334 36 ( ( -LRB- cord-001397-nrq4ncdf 334 37 Crowder Crowder NNP cord-001397-nrq4ncdf 334 38 et et NNP cord-001397-nrq4ncdf 334 39 al al NNP cord-001397-nrq4ncdf 334 40 . . NNP cord-001397-nrq4ncdf 334 41 , , , cord-001397-nrq4ncdf 334 42 2013 2013 CD cord-001397-nrq4ncdf 334 43 ) ) -RRB- cord-001397-nrq4ncdf 334 44 . . . cord-001397-nrq4ncdf 335 1 However however RB cord-001397-nrq4ncdf 335 2 , , , cord-001397-nrq4ncdf 335 3 a a DT cord-001397-nrq4ncdf 335 4 study study NN cord-001397-nrq4ncdf 335 5 conducted conduct VBN cord-001397-nrq4ncdf 335 6 in in IN cord-001397-nrq4ncdf 335 7 Stratford Stratford NNP cord-001397-nrq4ncdf 335 8 , , , cord-001397-nrq4ncdf 335 9 Connecticut Connecticut NNP cord-001397-nrq4ncdf 335 10 , , , cord-001397-nrq4ncdf 335 11 showed show VBD cord-001397-nrq4ncdf 335 12 that that IN cord-001397-nrq4ncdf 335 13 the the DT cord-001397-nrq4ncdf 335 14 C. C. NNP cord-001397-nrq4ncdf 335 15 pipiens pipien NNS cord-001397-nrq4ncdf 335 16 was be VBD cord-001397-nrq4ncdf 335 17 the the DT cord-001397-nrq4ncdf 335 18 most most RBS cord-001397-nrq4ncdf 335 19 dominant dominant JJ cord-001397-nrq4ncdf 335 20 mosquito mosquito NN cord-001397-nrq4ncdf 335 21 captured capture VBN cord-001397-nrq4ncdf 335 22 in in IN cord-001397-nrq4ncdf 335 23 this this DT cord-001397-nrq4ncdf 335 24 WNV WNV NNP cord-001397-nrq4ncdf 335 25 focus focus NN cord-001397-nrq4ncdf 335 26 area area NN cord-001397-nrq4ncdf 335 27 ( ( -LRB- cord-001397-nrq4ncdf 335 28 Anderson Anderson NNP cord-001397-nrq4ncdf 335 29 et et NNP cord-001397-nrq4ncdf 335 30 al al NNP cord-001397-nrq4ncdf 335 31 . . NNP cord-001397-nrq4ncdf 335 32 , , , cord-001397-nrq4ncdf 335 33 2004 2004 CD cord-001397-nrq4ncdf 335 34 ) ) -RRB- cord-001397-nrq4ncdf 335 35 . . . cord-001397-nrq4ncdf 336 1 In in IN cord-001397-nrq4ncdf 336 2 the the DT cord-001397-nrq4ncdf 336 3 captured capture VBN cord-001397-nrq4ncdf 336 4 mosquitoes mosquito NNS cord-001397-nrq4ncdf 336 5 , , , cord-001397-nrq4ncdf 336 6 more more JJR cord-001397-nrq4ncdf 336 7 than than IN cord-001397-nrq4ncdf 336 8 85 85 CD cord-001397-nrq4ncdf 336 9 % % NN cord-001397-nrq4ncdf 336 10 of of IN cord-001397-nrq4ncdf 336 11 WNV WNV NNP cord-001397-nrq4ncdf 336 12 isolations isolation NNS cord-001397-nrq4ncdf 336 13 were be VBD cord-001397-nrq4ncdf 336 14 from from IN cord-001397-nrq4ncdf 336 15 the the DT cord-001397-nrq4ncdf 336 16 same same JJ cord-001397-nrq4ncdf 336 17 species specie NNS cord-001397-nrq4ncdf 336 18 , , , cord-001397-nrq4ncdf 336 19 whereas whereas IN cord-001397-nrq4ncdf 336 20 Culex Culex NNP cord-001397-nrq4ncdf 336 21 salinarius salinarius NN cord-001397-nrq4ncdf 336 22 accounted account VBD cord-001397-nrq4ncdf 336 23 for for IN cord-001397-nrq4ncdf 336 24 between between IN cord-001397-nrq4ncdf 336 25 5 5 CD cord-001397-nrq4ncdf 336 26 % % NN cord-001397-nrq4ncdf 336 27 and and CC cord-001397-nrq4ncdf 336 28 12 12 CD cord-001397-nrq4ncdf 336 29 % % NN cord-001397-nrq4ncdf 336 30 ( ( -LRB- cord-001397-nrq4ncdf 336 31 Anderson Anderson NNP cord-001397-nrq4ncdf 336 32 et et NNP cord-001397-nrq4ncdf 336 33 al al NNP cord-001397-nrq4ncdf 336 34 . . NNP cord-001397-nrq4ncdf 336 35 , , , cord-001397-nrq4ncdf 336 36 2004 2004 CD cord-001397-nrq4ncdf 336 37 ) ) -RRB- cord-001397-nrq4ncdf 336 38 . . . cord-001397-nrq4ncdf 337 1 In in IN cord-001397-nrq4ncdf 337 2 a a DT cord-001397-nrq4ncdf 337 3 similar similar JJ cord-001397-nrq4ncdf 337 4 study study NN cord-001397-nrq4ncdf 337 5 conducted conduct VBN cord-001397-nrq4ncdf 337 6 in in IN cord-001397-nrq4ncdf 337 7 Mexico Mexico NNP cord-001397-nrq4ncdf 337 8 , , , cord-001397-nrq4ncdf 337 9 C. C. NNP cord-001397-nrq4ncdf 337 10 quinquefasciatus quinquefasciatus NNP cord-001397-nrq4ncdf 337 11 was be VBD cord-001397-nrq4ncdf 337 12 more more RBR cord-001397-nrq4ncdf 337 13 common common JJ cord-001397-nrq4ncdf 337 14 at at IN cord-001397-nrq4ncdf 337 15 48.3 48.3 CD cord-001397-nrq4ncdf 337 16 % % NN cord-001397-nrq4ncdf 337 17 and and CC cord-001397-nrq4ncdf 337 18 MBFV MBFV NNP cord-001397-nrq4ncdf 337 19 RNA RNA NNP cord-001397-nrq4ncdf 337 20 was be VBD cord-001397-nrq4ncdf 337 21 detected detect VBN cord-001397-nrq4ncdf 337 22 in in IN cord-001397-nrq4ncdf 337 23 70 70 CD cord-001397-nrq4ncdf 337 24 % % NN cord-001397-nrq4ncdf 337 25 of of IN cord-001397-nrq4ncdf 337 26 the the DT cord-001397-nrq4ncdf 337 27 pools pool NNS cord-001397-nrq4ncdf 337 28 ( ( -LRB- cord-001397-nrq4ncdf 337 29 Farfan Farfan NNP cord-001397-nrq4ncdf 337 30 - - HYPH cord-001397-nrq4ncdf 337 31 Ale Ale NNP cord-001397-nrq4ncdf 337 32 et et FW cord-001397-nrq4ncdf 337 33 al al NNP cord-001397-nrq4ncdf 337 34 . . NNP cord-001397-nrq4ncdf 337 35 , , , cord-001397-nrq4ncdf 337 36 2009 2009 CD cord-001397-nrq4ncdf 337 37 ) ) -RRB- cord-001397-nrq4ncdf 337 38 . . . cord-001397-nrq4ncdf 338 1 It -PRON- PRP cord-001397-nrq4ncdf 338 2 is be VBZ cord-001397-nrq4ncdf 338 3 evident evident JJ cord-001397-nrq4ncdf 338 4 that that IN cord-001397-nrq4ncdf 338 5 mosquitoes mosquito NNS cord-001397-nrq4ncdf 338 6 are be VBP cord-001397-nrq4ncdf 338 7 important important JJ cord-001397-nrq4ncdf 338 8 as as IN cord-001397-nrq4ncdf 338 9 viral viral JJ cord-001397-nrq4ncdf 338 10 hosts host NNS cord-001397-nrq4ncdf 338 11 and and CC cord-001397-nrq4ncdf 338 12 vectors vector NNS cord-001397-nrq4ncdf 338 13 . . . cord-001397-nrq4ncdf 339 1 Furthermore furthermore RB cord-001397-nrq4ncdf 339 2 , , , cord-001397-nrq4ncdf 339 3 it -PRON- PRP cord-001397-nrq4ncdf 339 4 can can MD cord-001397-nrq4ncdf 339 5 be be VB cord-001397-nrq4ncdf 339 6 concluded conclude VBN cord-001397-nrq4ncdf 339 7 that that IN cord-001397-nrq4ncdf 339 8 the the DT cord-001397-nrq4ncdf 339 9 MBFVs mbfv NNS cord-001397-nrq4ncdf 339 10 have have VBP cord-001397-nrq4ncdf 339 11 evolved evolve VBN cord-001397-nrq4ncdf 339 12 mechanisms mechanism NNS cord-001397-nrq4ncdf 339 13 of of IN cord-001397-nrq4ncdf 339 14 evading evade VBG cord-001397-nrq4ncdf 339 15 the the DT cord-001397-nrq4ncdf 339 16 host host NN cord-001397-nrq4ncdf 339 17 innate innate JJ cord-001397-nrq4ncdf 339 18 responses response NNS cord-001397-nrq4ncdf 339 19 to to TO cord-001397-nrq4ncdf 339 20 persist persist VB cord-001397-nrq4ncdf 339 21 in in IN cord-001397-nrq4ncdf 339 22 the the DT cord-001397-nrq4ncdf 339 23 MBFVs mbfv NNS cord-001397-nrq4ncdf 339 24 . . . cord-001397-nrq4ncdf 340 1 The the DT cord-001397-nrq4ncdf 340 2 principal principal JJ cord-001397-nrq4ncdf 340 3 vertebrate vertebrate JJ cord-001397-nrq4ncdf 340 4 hosts host NNS cord-001397-nrq4ncdf 340 5 for for IN cord-001397-nrq4ncdf 340 6 VBFVs vbfv NNS cord-001397-nrq4ncdf 340 7 are be VBP cord-001397-nrq4ncdf 340 8 small small JJ cord-001397-nrq4ncdf 340 9 mammals mammal NNS cord-001397-nrq4ncdf 340 10 , , , cord-001397-nrq4ncdf 340 11 marsupials marsupial NNS cord-001397-nrq4ncdf 340 12 , , , cord-001397-nrq4ncdf 340 13 and and CC cord-001397-nrq4ncdf 340 14 birds bird NNS cord-001397-nrq4ncdf 340 15 ( ( -LRB- cord-001397-nrq4ncdf 340 16 Fig fig NN cord-001397-nrq4ncdf 340 17 . . . cord-001397-nrq4ncdf 340 18 1 1 CD cord-001397-nrq4ncdf 340 19 ) ) -RRB- cord-001397-nrq4ncdf 340 20 , , , cord-001397-nrq4ncdf 340 21 but but CC cord-001397-nrq4ncdf 340 22 the the DT cord-001397-nrq4ncdf 340 23 viruses virus NNS cord-001397-nrq4ncdf 340 24 can can MD cord-001397-nrq4ncdf 340 25 also also RB cord-001397-nrq4ncdf 340 26 infect infect VB cord-001397-nrq4ncdf 340 27 reptiles reptile NNS cord-001397-nrq4ncdf 340 28 ( ( -LRB- cord-001397-nrq4ncdf 340 29 Mackenzie Mackenzie NNP cord-001397-nrq4ncdf 340 30 et et NNP cord-001397-nrq4ncdf 340 31 al al NNP cord-001397-nrq4ncdf 340 32 . . NNP cord-001397-nrq4ncdf 340 33 , , , cord-001397-nrq4ncdf 340 34 2002 2002 CD cord-001397-nrq4ncdf 340 35 ( ( -LRB- cord-001397-nrq4ncdf 340 36 Mackenzie Mackenzie NNP cord-001397-nrq4ncdf 340 37 et et NNP cord-001397-nrq4ncdf 340 38 al al NNP cord-001397-nrq4ncdf 340 39 . . NNP cord-001397-nrq4ncdf 340 40 , , , cord-001397-nrq4ncdf 340 41 , , , cord-001397-nrq4ncdf 340 42 2004 2004 CD cord-001397-nrq4ncdf 341 1 Steinman Steinman NNP cord-001397-nrq4ncdf 341 2 et et NNP cord-001397-nrq4ncdf 341 3 al al NNP cord-001397-nrq4ncdf 341 4 . . NNP cord-001397-nrq4ncdf 341 5 , , , cord-001397-nrq4ncdf 341 6 2003 2003 CD cord-001397-nrq4ncdf 342 1 ; ; : cord-001397-nrq4ncdf 342 2 Jacobson Jacobson NNP cord-001397-nrq4ncdf 342 3 et et NNP cord-001397-nrq4ncdf 342 4 al al NNP cord-001397-nrq4ncdf 342 5 . . . cord-001397-nrq4ncdf 343 1 , , , cord-001397-nrq4ncdf 343 2 2005 2005 CD cord-001397-nrq4ncdf 343 3 ; ; : cord-001397-nrq4ncdf 343 4 Root Root NNP cord-001397-nrq4ncdf 343 5 et et FW cord-001397-nrq4ncdf 343 6 al al NNP cord-001397-nrq4ncdf 343 7 . . NNP cord-001397-nrq4ncdf 343 8 , , , cord-001397-nrq4ncdf 343 9 2005 2005 CD cord-001397-nrq4ncdf 343 10 ; ; : cord-001397-nrq4ncdf 344 1 Marschang Marschang NNP cord-001397-nrq4ncdf 344 2 , , , cord-001397-nrq4ncdf 344 3 2011 2011 CD cord-001397-nrq4ncdf 344 4 ) ) -RRB- cord-001397-nrq4ncdf 344 5 . . . cord-001397-nrq4ncdf 345 1 In in IN cord-001397-nrq4ncdf 345 2 most most JJS cord-001397-nrq4ncdf 345 3 instances instance NNS cord-001397-nrq4ncdf 345 4 , , , cord-001397-nrq4ncdf 345 5 larger large JJR cord-001397-nrq4ncdf 345 6 animals animal NNS cord-001397-nrq4ncdf 345 7 , , , cord-001397-nrq4ncdf 345 8 such such JJ cord-001397-nrq4ncdf 345 9 as as IN cord-001397-nrq4ncdf 345 10 cervids cervid NNS cord-001397-nrq4ncdf 345 11 , , , cord-001397-nrq4ncdf 345 12 goats goat NNS cord-001397-nrq4ncdf 345 13 , , , cord-001397-nrq4ncdf 345 14 and and CC cord-001397-nrq4ncdf 345 15 sheep sheep NNS cord-001397-nrq4ncdf 345 16 , , , cord-001397-nrq4ncdf 345 17 are be VBP cord-001397-nrq4ncdf 345 18 incidental incidental JJ cord-001397-nrq4ncdf 345 19 hosts host NNS cord-001397-nrq4ncdf 345 20 . . . cord-001397-nrq4ncdf 346 1 The the DT cord-001397-nrq4ncdf 346 2 1999 1999 CD cord-001397-nrq4ncdf 346 3 outbreak outbreak NN cord-001397-nrq4ncdf 346 4 of of IN cord-001397-nrq4ncdf 346 5 WNV WNV NNP cord-001397-nrq4ncdf 346 6 in in IN cord-001397-nrq4ncdf 346 7 humans human NNS cord-001397-nrq4ncdf 346 8 in in IN cord-001397-nrq4ncdf 346 9 New New NNP cord-001397-nrq4ncdf 346 10 York York NNP cord-001397-nrq4ncdf 346 11 is be VBZ cord-001397-nrq4ncdf 346 12 thought think VBN cord-001397-nrq4ncdf 346 13 to to TO cord-001397-nrq4ncdf 346 14 be be VB cord-001397-nrq4ncdf 346 15 associated associate VBN cord-001397-nrq4ncdf 346 16 with with IN cord-001397-nrq4ncdf 346 17 WNV WNV NNP cord-001397-nrq4ncdf 346 18 infection infection NN cord-001397-nrq4ncdf 346 19 in in IN cord-001397-nrq4ncdf 346 20 birds bird NNS cord-001397-nrq4ncdf 347 1 ( ( -LRB- cord-001397-nrq4ncdf 347 2 Strausbaugh Strausbaugh NNP cord-001397-nrq4ncdf 347 3 et et NNP cord-001397-nrq4ncdf 347 4 al al NNP cord-001397-nrq4ncdf 347 5 . . NNP cord-001397-nrq4ncdf 347 6 , , , cord-001397-nrq4ncdf 347 7 2001 2001 CD cord-001397-nrq4ncdf 347 8 ) ) -RRB- cord-001397-nrq4ncdf 347 9 . . . cord-001397-nrq4ncdf 348 1 The the DT cord-001397-nrq4ncdf 348 2 mosquito mosquito NN cord-001397-nrq4ncdf 348 3 - - HYPH cord-001397-nrq4ncdf 348 4 borne bear VBN cord-001397-nrq4ncdf 348 5 Wesselsbron Wesselsbron NNP cord-001397-nrq4ncdf 348 6 virus virus NN cord-001397-nrq4ncdf 348 7 could could MD cord-001397-nrq4ncdf 348 8 also also RB cord-001397-nrq4ncdf 348 9 be be VB cord-001397-nrq4ncdf 348 10 cycled cycle VBN cord-001397-nrq4ncdf 348 11 between between IN cord-001397-nrq4ncdf 348 12 mosquitoes mosquito NNS cord-001397-nrq4ncdf 348 13 and and CC cord-001397-nrq4ncdf 348 14 birds bird NNS cord-001397-nrq4ncdf 348 15 , , , cord-001397-nrq4ncdf 348 16 but but CC cord-001397-nrq4ncdf 348 17 not not RB cord-001397-nrq4ncdf 348 18 much much JJ cord-001397-nrq4ncdf 348 19 is be VBZ cord-001397-nrq4ncdf 348 20 known know VBN cord-001397-nrq4ncdf 348 21 about about IN cord-001397-nrq4ncdf 348 22 the the DT cord-001397-nrq4ncdf 348 23 vertebrate vertebrate JJ cord-001397-nrq4ncdf 348 24 host(s host(s NNP cord-001397-nrq4ncdf 348 25 ) ) -RRB- cord-001397-nrq4ncdf 348 26 . . . cord-001397-nrq4ncdf 349 1 Thus thus RB cord-001397-nrq4ncdf 349 2 , , , cord-001397-nrq4ncdf 349 3 in in IN cord-001397-nrq4ncdf 349 4 nature nature NN cord-001397-nrq4ncdf 349 5 , , , cord-001397-nrq4ncdf 349 6 numerous numerous JJ cord-001397-nrq4ncdf 349 7 species specie NNS cord-001397-nrq4ncdf 349 8 are be VBP cord-001397-nrq4ncdf 349 9 susceptible susceptible JJ cord-001397-nrq4ncdf 349 10 to to IN cord-001397-nrq4ncdf 349 11 VBFVs vbfv NNS cord-001397-nrq4ncdf 349 12 and and CC cord-001397-nrq4ncdf 349 13 might may MD cord-001397-nrq4ncdf 349 14 serve serve VB cord-001397-nrq4ncdf 349 15 as as IN cord-001397-nrq4ncdf 349 16 reservoirs reservoir NNS cord-001397-nrq4ncdf 349 17 or or CC cord-001397-nrq4ncdf 349 18 secondary secondary JJ cord-001397-nrq4ncdf 349 19 amplifying amplify VBG cord-001397-nrq4ncdf 349 20 hosts host NNS cord-001397-nrq4ncdf 349 21 . . . cord-001397-nrq4ncdf 350 1 In in IN cord-001397-nrq4ncdf 350 2 this this DT cord-001397-nrq4ncdf 350 3 section section NN cord-001397-nrq4ncdf 350 4 , , , cord-001397-nrq4ncdf 350 5 we -PRON- PRP cord-001397-nrq4ncdf 350 6 will will MD cord-001397-nrq4ncdf 350 7 survey survey VB cord-001397-nrq4ncdf 350 8 the the DT cord-001397-nrq4ncdf 350 9 literature literature NN cord-001397-nrq4ncdf 350 10 and and CC cord-001397-nrq4ncdf 350 11 the the DT cord-001397-nrq4ncdf 350 12 three three CD cord-001397-nrq4ncdf 350 13 potential potential JJ cord-001397-nrq4ncdf 350 14 markers marker NNS cord-001397-nrq4ncdf 350 15 for for IN cord-001397-nrq4ncdf 350 16 viral viral JJ cord-001397-nrq4ncdf 350 17 persistence persistence NN cord-001397-nrq4ncdf 350 18 : : : cord-001397-nrq4ncdf 350 19 isolation isolation NN cord-001397-nrq4ncdf 350 20 of of IN cord-001397-nrq4ncdf 350 21 virus virus NN cord-001397-nrq4ncdf 350 22 , , , cord-001397-nrq4ncdf 350 23 identification identification NN cord-001397-nrq4ncdf 350 24 of of IN cord-001397-nrq4ncdf 350 25 viral viral JJ cord-001397-nrq4ncdf 350 26 RNA RNA NNP cord-001397-nrq4ncdf 350 27 or or CC cord-001397-nrq4ncdf 350 28 protein protein NN cord-001397-nrq4ncdf 350 29 , , , cord-001397-nrq4ncdf 350 30 and and CC cord-001397-nrq4ncdf 350 31 viral viral JJ cord-001397-nrq4ncdf 350 32 serology serology NN cord-001397-nrq4ncdf 350 33 . . . cord-001397-nrq4ncdf 351 1 Small small JJ cord-001397-nrq4ncdf 351 2 mammals mammal NNS cord-001397-nrq4ncdf 351 3 , , , cord-001397-nrq4ncdf 351 4 particularly particularly RB cord-001397-nrq4ncdf 351 5 rodents rodent NNS cord-001397-nrq4ncdf 351 6 , , , cord-001397-nrq4ncdf 351 7 are be VBP cord-001397-nrq4ncdf 351 8 the the DT cord-001397-nrq4ncdf 351 9 principal principal JJ cord-001397-nrq4ncdf 351 10 vertebrate vertebrate JJ cord-001397-nrq4ncdf 351 11 hosts host NNS cord-001397-nrq4ncdf 351 12 and and CC cord-001397-nrq4ncdf 351 13 reservoirs reservoir NNS cord-001397-nrq4ncdf 351 14 for for IN cord-001397-nrq4ncdf 351 15 TBFVs tbfv NNS cord-001397-nrq4ncdf 352 1 ( ( -LRB- cord-001397-nrq4ncdf 352 2 Mansfield Mansfield NNP cord-001397-nrq4ncdf 352 3 et et NNP cord-001397-nrq4ncdf 352 4 al al NNP cord-001397-nrq4ncdf 352 5 . . NNP cord-001397-nrq4ncdf 352 6 , , , cord-001397-nrq4ncdf 352 7 2009 2009 CD cord-001397-nrq4ncdf 352 8 ; ; : cord-001397-nrq4ncdf 352 9 Dobler Dobler NNP cord-001397-nrq4ncdf 352 10 et et NNP cord-001397-nrq4ncdf 352 11 al al NNP cord-001397-nrq4ncdf 352 12 . . NNP cord-001397-nrq4ncdf 352 13 , , , cord-001397-nrq4ncdf 352 14 2012 2012 CD cord-001397-nrq4ncdf 352 15 ) ) -RRB- cord-001397-nrq4ncdf 352 16 . . . cord-001397-nrq4ncdf 353 1 In in IN cord-001397-nrq4ncdf 353 2 Europe Europe NNP cord-001397-nrq4ncdf 353 3 , , , cord-001397-nrq4ncdf 353 4 the the DT cord-001397-nrq4ncdf 353 5 yellow yellow JJ cord-001397-nrq4ncdf 353 6 - - HYPH cord-001397-nrq4ncdf 353 7 necked necked JJ cord-001397-nrq4ncdf 353 8 mouse mouse NN cord-001397-nrq4ncdf 353 9 ( ( -LRB- cord-001397-nrq4ncdf 353 10 Apodemus Apodemus NNP cord-001397-nrq4ncdf 353 11 flavicollis flavicollis NNP cord-001397-nrq4ncdf 353 12 ) ) -RRB- cord-001397-nrq4ncdf 353 13 and and CC cord-001397-nrq4ncdf 353 14 bank bank NN cord-001397-nrq4ncdf 353 15 vole vole NNP cord-001397-nrq4ncdf 353 16 ( ( -LRB- cord-001397-nrq4ncdf 353 17 Myodes Myodes NNP cord-001397-nrq4ncdf 353 18 glareolus glareolus NNP cord-001397-nrq4ncdf 353 19 ) ) -RRB- cord-001397-nrq4ncdf 353 20 are be VBP cord-001397-nrq4ncdf 353 21 implicated implicate VBN cord-001397-nrq4ncdf 353 22 as as IN cord-001397-nrq4ncdf 353 23 the the DT cord-001397-nrq4ncdf 353 24 most most RBS cord-001397-nrq4ncdf 353 25 common common JJ cord-001397-nrq4ncdf 353 26 hosts host NNS cord-001397-nrq4ncdf 353 27 , , , cord-001397-nrq4ncdf 353 28 and and CC cord-001397-nrq4ncdf 353 29 they -PRON- PRP cord-001397-nrq4ncdf 353 30 develop develop VBP cord-001397-nrq4ncdf 353 31 sufficient sufficient JJ cord-001397-nrq4ncdf 353 32 viremia viremia NN cord-001397-nrq4ncdf 353 33 to to TO cord-001397-nrq4ncdf 353 34 infect infect VB cord-001397-nrq4ncdf 353 35 ticks tick NNS cord-001397-nrq4ncdf 353 36 that that WDT cord-001397-nrq4ncdf 353 37 feed feed VBP cord-001397-nrq4ncdf 353 38 on on IN cord-001397-nrq4ncdf 353 39 them -PRON- PRP cord-001397-nrq4ncdf 354 1 ( ( -LRB- cord-001397-nrq4ncdf 354 2 Weidmann Weidmann NNP cord-001397-nrq4ncdf 354 3 et et NNP cord-001397-nrq4ncdf 354 4 al al NNP cord-001397-nrq4ncdf 354 5 . . NNP cord-001397-nrq4ncdf 354 6 , , , cord-001397-nrq4ncdf 354 7 2011 2011 CD cord-001397-nrq4ncdf 355 1 ; ; : cord-001397-nrq4ncdf 355 2 Dobler Dobler NNP cord-001397-nrq4ncdf 355 3 et et NNP cord-001397-nrq4ncdf 355 4 al al NNP cord-001397-nrq4ncdf 355 5 . . . cord-001397-nrq4ncdf 356 1 , , , cord-001397-nrq4ncdf 356 2 2012 2012 CD cord-001397-nrq4ncdf 356 3 ; ; : cord-001397-nrq4ncdf 356 4 Knap Knap NNP cord-001397-nrq4ncdf 356 5 et et FW cord-001397-nrq4ncdf 356 6 al al NNP cord-001397-nrq4ncdf 356 7 . . NNP cord-001397-nrq4ncdf 356 8 , , , cord-001397-nrq4ncdf 356 9 2012 2012 CD cord-001397-nrq4ncdf 356 10 ) ) -RRB- cord-001397-nrq4ncdf 356 11 . . . cord-001397-nrq4ncdf 357 1 In in IN cord-001397-nrq4ncdf 357 2 various various JJ cord-001397-nrq4ncdf 357 3 wild wild JJ cord-001397-nrq4ncdf 357 4 rodent rodent NN cord-001397-nrq4ncdf 357 5 species specie NNS cord-001397-nrq4ncdf 357 6 captured capture VBN cord-001397-nrq4ncdf 357 7 in in IN cord-001397-nrq4ncdf 357 8 Brandenburg Brandenburg NNP cord-001397-nrq4ncdf 357 9 , , , cord-001397-nrq4ncdf 357 10 Germany Germany NNP cord-001397-nrq4ncdf 357 11 , , , cord-001397-nrq4ncdf 357 12 an an DT cord-001397-nrq4ncdf 357 13 average average JJ cord-001397-nrq4ncdf 357 14 TBEV TBEV NNP cord-001397-nrq4ncdf 357 15 infection infection NN cord-001397-nrq4ncdf 357 16 rate rate NN cord-001397-nrq4ncdf 357 17 of of IN cord-001397-nrq4ncdf 357 18 15 15 CD cord-001397-nrq4ncdf 357 19 % % NN cord-001397-nrq4ncdf 357 20 was be VBD cord-001397-nrq4ncdf 357 21 reported report VBN cord-001397-nrq4ncdf 357 22 ( ( -LRB- cord-001397-nrq4ncdf 357 23 Achazi Achazi NNP cord-001397-nrq4ncdf 357 24 et et NNP cord-001397-nrq4ncdf 357 25 al al NNP cord-001397-nrq4ncdf 357 26 . . NNP cord-001397-nrq4ncdf 357 27 , , , cord-001397-nrq4ncdf 357 28 2011 2011 CD cord-001397-nrq4ncdf 357 29 ) ) -RRB- cord-001397-nrq4ncdf 357 30 . . . cord-001397-nrq4ncdf 358 1 In in IN cord-001397-nrq4ncdf 358 2 the the DT cord-001397-nrq4ncdf 358 3 captured capture VBN cord-001397-nrq4ncdf 358 4 rodents rodent NNS cord-001397-nrq4ncdf 358 5 , , , cord-001397-nrq4ncdf 358 6 TBEV TBEV NNP cord-001397-nrq4ncdf 358 7 RNA RNA NNP cord-001397-nrq4ncdf 358 8 was be VBD cord-001397-nrq4ncdf 358 9 detected detect VBN cord-001397-nrq4ncdf 358 10 by by IN cord-001397-nrq4ncdf 358 11 RT RT NNP cord-001397-nrq4ncdf 358 12 - - HYPH cord-001397-nrq4ncdf 358 13 PCR PCR NNP cord-001397-nrq4ncdf 358 14 in in IN cord-001397-nrq4ncdf 358 15 the the DT cord-001397-nrq4ncdf 358 16 brains brain NNS cord-001397-nrq4ncdf 358 17 and and CC cord-001397-nrq4ncdf 358 18 spleens spleen NNS cord-001397-nrq4ncdf 358 19 . . . cord-001397-nrq4ncdf 359 1 In in IN cord-001397-nrq4ncdf 359 2 North North NNP cord-001397-nrq4ncdf 359 3 America America NNP cord-001397-nrq4ncdf 359 4 , , , cord-001397-nrq4ncdf 359 5 deer deer NN cord-001397-nrq4ncdf 359 6 mice mouse NNS cord-001397-nrq4ncdf 359 7 ( ( -LRB- cord-001397-nrq4ncdf 359 8 Peromyscus Peromyscus NNP cord-001397-nrq4ncdf 359 9 ) ) -RRB- cord-001397-nrq4ncdf 359 10 , , , cord-001397-nrq4ncdf 359 11 squirrels squirrel NNS cord-001397-nrq4ncdf 359 12 , , , cord-001397-nrq4ncdf 359 13 and and CC cord-001397-nrq4ncdf 359 14 the the DT cord-001397-nrq4ncdf 359 15 striped striped JJ cord-001397-nrq4ncdf 359 16 skunk skunk NN cord-001397-nrq4ncdf 359 17 ( ( -LRB- cord-001397-nrq4ncdf 359 18 Mephitis Mephitis NNP cord-001397-nrq4ncdf 359 19 mephitis mephitis NN cord-001397-nrq4ncdf 359 20 ) ) -RRB- cord-001397-nrq4ncdf 359 21 are be VBP cord-001397-nrq4ncdf 359 22 important important JJ cord-001397-nrq4ncdf 359 23 reservoirs reservoir NNS cord-001397-nrq4ncdf 359 24 of of IN cord-001397-nrq4ncdf 359 25 POWV POWV NNP cord-001397-nrq4ncdf 359 26 and and CC cord-001397-nrq4ncdf 359 27 DTV DTV NNP cord-001397-nrq4ncdf 360 1 ( ( -LRB- cord-001397-nrq4ncdf 360 2 Main Main NNP cord-001397-nrq4ncdf 360 3 et et FW cord-001397-nrq4ncdf 360 4 al al NNP cord-001397-nrq4ncdf 360 5 . . NNP cord-001397-nrq4ncdf 360 6 , , , cord-001397-nrq4ncdf 360 7 1979 1979 CD cord-001397-nrq4ncdf 360 8 ; ; : cord-001397-nrq4ncdf 360 9 Telford Telford NNP cord-001397-nrq4ncdf 360 10 et et NNP cord-001397-nrq4ncdf 360 11 al al NNP cord-001397-nrq4ncdf 360 12 . . NNP cord-001397-nrq4ncdf 360 13 , , , cord-001397-nrq4ncdf 360 14 1997 1997 CD cord-001397-nrq4ncdf 360 15 ) ) -RRB- cord-001397-nrq4ncdf 360 16 . . . cord-001397-nrq4ncdf 361 1 Based base VBN cord-001397-nrq4ncdf 361 2 on on IN cord-001397-nrq4ncdf 361 3 serological serological JJ cord-001397-nrq4ncdf 361 4 studies study NNS cord-001397-nrq4ncdf 361 5 , , , cord-001397-nrq4ncdf 361 6 a a DT cord-001397-nrq4ncdf 361 7 6.2 6.2 CD cord-001397-nrq4ncdf 361 8 % % NN cord-001397-nrq4ncdf 361 9 DTV DTV NNP cord-001397-nrq4ncdf 361 10 prevalence prevalence NN cord-001397-nrq4ncdf 361 11 in in IN cord-001397-nrq4ncdf 361 12 the the DT cord-001397-nrq4ncdf 361 13 red red NN cord-001397-nrq4ncdf 361 14 - - HYPH cord-001397-nrq4ncdf 361 15 backed back VBN cord-001397-nrq4ncdf 361 16 voles vole NNS cord-001397-nrq4ncdf 361 17 ( ( -LRB- cord-001397-nrq4ncdf 361 18 Myodes Myodes NNP cord-001397-nrq4ncdf 361 19 rutilus rutilus NNP cord-001397-nrq4ncdf 361 20 ) ) -RRB- cord-001397-nrq4ncdf 361 21 was be VBD cord-001397-nrq4ncdf 361 22 found find VBN cord-001397-nrq4ncdf 361 23 in in IN cord-001397-nrq4ncdf 361 24 Siberia Siberia NNP cord-001397-nrq4ncdf 361 25 and and CC cord-001397-nrq4ncdf 361 26 Alaska Alaska NNP cord-001397-nrq4ncdf 361 27 ( ( -LRB- cord-001397-nrq4ncdf 361 28 Deardorff Deardorff NNP cord-001397-nrq4ncdf 361 29 et et NNP cord-001397-nrq4ncdf 361 30 al al NNP cord-001397-nrq4ncdf 361 31 . . NNP cord-001397-nrq4ncdf 361 32 , , , cord-001397-nrq4ncdf 361 33 2013 2013 CD cord-001397-nrq4ncdf 361 34 ) ) -RRB- cord-001397-nrq4ncdf 361 35 . . . cord-001397-nrq4ncdf 362 1 DTV DTV NNP cord-001397-nrq4ncdf 362 2 in in IN cord-001397-nrq4ncdf 362 3 New New NNP cord-001397-nrq4ncdf 362 4 Mexico Mexico NNP cord-001397-nrq4ncdf 362 5 was be VBD cord-001397-nrq4ncdf 362 6 serologically serologically RB cord-001397-nrq4ncdf 362 7 prevalent prevalent JJ cord-001397-nrq4ncdf 362 8 in in IN cord-001397-nrq4ncdf 362 9 Peromyscus Peromyscus NNP cord-001397-nrq4ncdf 362 10 truei truei NN cord-001397-nrq4ncdf 362 11 and and CC cord-001397-nrq4ncdf 362 12 Peromyscus Peromyscus NNP cord-001397-nrq4ncdf 362 13 maniculatus maniculatus NNP cord-001397-nrq4ncdf 362 14 at at IN cord-001397-nrq4ncdf 362 15 22.2 22.2 CD cord-001397-nrq4ncdf 362 16 % % NN cord-001397-nrq4ncdf 362 17 and and CC cord-001397-nrq4ncdf 362 18 6.0 6.0 CD cord-001397-nrq4ncdf 362 19 % % NN cord-001397-nrq4ncdf 362 20 , , , cord-001397-nrq4ncdf 362 21 respectively respectively RB cord-001397-nrq4ncdf 363 1 ( ( -LRB- cord-001397-nrq4ncdf 363 2 Deardorff Deardorff NNP cord-001397-nrq4ncdf 363 3 et et NNP cord-001397-nrq4ncdf 363 4 al al NNP cord-001397-nrq4ncdf 363 5 . . NNP cord-001397-nrq4ncdf 363 6 , , , cord-001397-nrq4ncdf 363 7 2013 2013 CD cord-001397-nrq4ncdf 363 8 ) ) -RRB- cord-001397-nrq4ncdf 363 9 . . . cord-001397-nrq4ncdf 364 1 Therefore therefore RB cord-001397-nrq4ncdf 364 2 , , , cord-001397-nrq4ncdf 364 3 it -PRON- PRP cord-001397-nrq4ncdf 364 4 seems seem VBZ cord-001397-nrq4ncdf 364 5 likely likely JJ cord-001397-nrq4ncdf 364 6 that that IN cord-001397-nrq4ncdf 364 7 persistent persistent JJ cord-001397-nrq4ncdf 364 8 infection infection NN cord-001397-nrq4ncdf 364 9 of of IN cord-001397-nrq4ncdf 364 10 these these DT cord-001397-nrq4ncdf 364 11 small small JJ cord-001397-nrq4ncdf 364 12 mammals mammal NNS cord-001397-nrq4ncdf 364 13 occurs occur VBZ cord-001397-nrq4ncdf 364 14 . . . cord-001397-nrq4ncdf 365 1 Deer Deer NNP cord-001397-nrq4ncdf 365 2 may may MD cord-001397-nrq4ncdf 365 3 stabilize stabilize VB cord-001397-nrq4ncdf 365 4 and and CC cord-001397-nrq4ncdf 365 5 maintain maintain VB cord-001397-nrq4ncdf 365 6 TBFVs tbfv NNS cord-001397-nrq4ncdf 365 7 at at IN cord-001397-nrq4ncdf 365 8 levels level NNS cord-001397-nrq4ncdf 365 9 that that WDT cord-001397-nrq4ncdf 365 10 are be VBP cord-001397-nrq4ncdf 365 11 important important JJ cord-001397-nrq4ncdf 365 12 for for IN cord-001397-nrq4ncdf 365 13 transmission transmission NN cord-001397-nrq4ncdf 365 14 ( ( -LRB- cord-001397-nrq4ncdf 365 15 Pugliese Pugliese NNP cord-001397-nrq4ncdf 365 16 et et NNP cord-001397-nrq4ncdf 365 17 al al NNP cord-001397-nrq4ncdf 365 18 . . NNP cord-001397-nrq4ncdf 365 19 , , , cord-001397-nrq4ncdf 365 20 2007 2007 CD cord-001397-nrq4ncdf 365 21 ; ; : cord-001397-nrq4ncdf 365 22 Carpi Carpi NNP cord-001397-nrq4ncdf 365 23 et et NNP cord-001397-nrq4ncdf 365 24 al al NNP cord-001397-nrq4ncdf 365 25 . . NNP cord-001397-nrq4ncdf 365 26 , , , cord-001397-nrq4ncdf 365 27 2009 2009 CD cord-001397-nrq4ncdf 365 28 ; ; : cord-001397-nrq4ncdf 365 29 McGee McGee NNP cord-001397-nrq4ncdf 365 30 et et NNP cord-001397-nrq4ncdf 365 31 al al NNP cord-001397-nrq4ncdf 365 32 . . NNP cord-001397-nrq4ncdf 365 33 , , , cord-001397-nrq4ncdf 365 34 2010 2010 CD cord-001397-nrq4ncdf 365 35 ; ; : cord-001397-nrq4ncdf 365 36 Dobler Dobler NNP cord-001397-nrq4ncdf 365 37 et et NNP cord-001397-nrq4ncdf 365 38 al al NNP cord-001397-nrq4ncdf 365 39 . . NNP cord-001397-nrq4ncdf 365 40 , , , cord-001397-nrq4ncdf 365 41 2012 2012 CD cord-001397-nrq4ncdf 365 42 ) ) -RRB- cord-001397-nrq4ncdf 365 43 . . . cord-001397-nrq4ncdf 366 1 While while IN cord-001397-nrq4ncdf 366 2 deer deer NN cord-001397-nrq4ncdf 366 3 are be VBP cord-001397-nrq4ncdf 366 4 important important JJ cord-001397-nrq4ncdf 366 5 sources source NNS cord-001397-nrq4ncdf 366 6 of of IN cord-001397-nrq4ncdf 366 7 blood blood NN cord-001397-nrq4ncdf 366 8 meals meal NNS cord-001397-nrq4ncdf 366 9 for for IN cord-001397-nrq4ncdf 366 10 ticks tick NNS cord-001397-nrq4ncdf 366 11 , , , cord-001397-nrq4ncdf 366 12 they -PRON- PRP cord-001397-nrq4ncdf 366 13 develop develop VBP cord-001397-nrq4ncdf 366 14 low low JJ cord-001397-nrq4ncdf 366 15 virus virus NN cord-001397-nrq4ncdf 366 16 titer titer NN cord-001397-nrq4ncdf 366 17 and and CC cord-001397-nrq4ncdf 366 18 are be VBP cord-001397-nrq4ncdf 366 19 therefore therefore RB cord-001397-nrq4ncdf 366 20 not not RB cord-001397-nrq4ncdf 366 21 competent competent JJ cord-001397-nrq4ncdf 366 22 in in IN cord-001397-nrq4ncdf 366 23 transmission transmission NN cord-001397-nrq4ncdf 366 24 of of IN cord-001397-nrq4ncdf 366 25 TBFVs tbfv NNS cord-001397-nrq4ncdf 366 26 . . . cord-001397-nrq4ncdf 367 1 However however RB cord-001397-nrq4ncdf 367 2 , , , cord-001397-nrq4ncdf 367 3 in in IN cord-001397-nrq4ncdf 367 4 a a DT cord-001397-nrq4ncdf 367 5 broader broad JJR cord-001397-nrq4ncdf 367 6 sense sense NN cord-001397-nrq4ncdf 367 7 , , , cord-001397-nrq4ncdf 367 8 deer deer NN cord-001397-nrq4ncdf 367 9 are be VBP cord-001397-nrq4ncdf 367 10 important important JJ cord-001397-nrq4ncdf 367 11 in in IN cord-001397-nrq4ncdf 367 12 viral viral JJ cord-001397-nrq4ncdf 367 13 persistence persistence NN cord-001397-nrq4ncdf 367 14 because because IN cord-001397-nrq4ncdf 367 15 they -PRON- PRP cord-001397-nrq4ncdf 367 16 help help VBP cord-001397-nrq4ncdf 367 17 sustain sustain VB cord-001397-nrq4ncdf 367 18 tick tick NN cord-001397-nrq4ncdf 367 19 populations population NNS cord-001397-nrq4ncdf 368 1 ( ( -LRB- cord-001397-nrq4ncdf 368 2 Cagnacci Cagnacci NNP cord-001397-nrq4ncdf 368 3 et et NNP cord-001397-nrq4ncdf 368 4 al al NNP cord-001397-nrq4ncdf 368 5 . . . cord-001397-nrq4ncdf 369 1 , , , cord-001397-nrq4ncdf 369 2 2012 2012 CD cord-001397-nrq4ncdf 369 3 ) ) -RRB- cord-001397-nrq4ncdf 369 4 . . . cord-001397-nrq4ncdf 370 1 The the DT cord-001397-nrq4ncdf 370 2 situation situation NN cord-001397-nrq4ncdf 370 3 for for IN cord-001397-nrq4ncdf 370 4 domesticated domesticate VBN cord-001397-nrq4ncdf 370 5 animals animal NNS cord-001397-nrq4ncdf 370 6 is be VBZ cord-001397-nrq4ncdf 370 7 also also RB cord-001397-nrq4ncdf 370 8 less less RBR cord-001397-nrq4ncdf 370 9 clear clear JJ cord-001397-nrq4ncdf 370 10 than than IN cord-001397-nrq4ncdf 370 11 for for IN cord-001397-nrq4ncdf 370 12 rodents rodent NNS cord-001397-nrq4ncdf 370 13 . . . cord-001397-nrq4ncdf 371 1 Dogs dog NNS cord-001397-nrq4ncdf 371 2 , , , cord-001397-nrq4ncdf 371 3 horses horse NNS cord-001397-nrq4ncdf 371 4 , , , cord-001397-nrq4ncdf 371 5 and and CC cord-001397-nrq4ncdf 371 6 monkeys monkey NNS cord-001397-nrq4ncdf 371 7 can can MD cord-001397-nrq4ncdf 371 8 be be VB cord-001397-nrq4ncdf 371 9 infected infect VBN cord-001397-nrq4ncdf 371 10 with with IN cord-001397-nrq4ncdf 371 11 TBFVs tbfv NNS cord-001397-nrq4ncdf 371 12 , , , cord-001397-nrq4ncdf 371 13 but but CC cord-001397-nrq4ncdf 371 14 case case NN cord-001397-nrq4ncdf 371 15 reports report NNS cord-001397-nrq4ncdf 371 16 in in IN cord-001397-nrq4ncdf 371 17 veterinary veterinary JJ cord-001397-nrq4ncdf 371 18 practice practice NN cord-001397-nrq4ncdf 371 19 are be VBP cord-001397-nrq4ncdf 371 20 relatively relatively RB cord-001397-nrq4ncdf 371 21 infrequent infrequent JJ cord-001397-nrq4ncdf 372 1 ( ( -LRB- cord-001397-nrq4ncdf 372 2 Jaenson Jaenson NNP cord-001397-nrq4ncdf 372 3 et et NNP cord-001397-nrq4ncdf 372 4 al al NNP cord-001397-nrq4ncdf 372 5 . . NNP cord-001397-nrq4ncdf 372 6 , , , cord-001397-nrq4ncdf 372 7 2012 2012 CD cord-001397-nrq4ncdf 372 8 ) ) -RRB- cord-001397-nrq4ncdf 372 9 . . . cord-001397-nrq4ncdf 373 1 Large large JJ cord-001397-nrq4ncdf 373 2 domesticated domesticated JJ cord-001397-nrq4ncdf 373 3 animals animal NNS cord-001397-nrq4ncdf 373 4 , , , cord-001397-nrq4ncdf 373 5 such such JJ cord-001397-nrq4ncdf 373 6 as as IN cord-001397-nrq4ncdf 373 7 goats goat NNS cord-001397-nrq4ncdf 373 8 , , , cord-001397-nrq4ncdf 373 9 sheep sheep NN cord-001397-nrq4ncdf 373 10 , , , cord-001397-nrq4ncdf 373 11 and and CC cord-001397-nrq4ncdf 373 12 cattle cattle NNS cord-001397-nrq4ncdf 373 13 , , , cord-001397-nrq4ncdf 373 14 become become VBP cord-001397-nrq4ncdf 373 15 viremic viremic JJ cord-001397-nrq4ncdf 373 16 for for IN cord-001397-nrq4ncdf 373 17 a a DT cord-001397-nrq4ncdf 373 18 short short JJ cord-001397-nrq4ncdf 373 19 while while NN cord-001397-nrq4ncdf 373 20 and and CC cord-001397-nrq4ncdf 373 21 develop develop VB cord-001397-nrq4ncdf 373 22 antibodies antibody NNS cord-001397-nrq4ncdf 373 23 following follow VBG cord-001397-nrq4ncdf 373 24 infection infection NN cord-001397-nrq4ncdf 373 25 with with IN cord-001397-nrq4ncdf 373 26 TBEV TBEV NNP cord-001397-nrq4ncdf 373 27 , , , cord-001397-nrq4ncdf 373 28 but but CC cord-001397-nrq4ncdf 373 29 do do VBP cord-001397-nrq4ncdf 373 30 not not RB cord-001397-nrq4ncdf 373 31 show show VB cord-001397-nrq4ncdf 373 32 any any DT cord-001397-nrq4ncdf 373 33 specific specific JJ cord-001397-nrq4ncdf 373 34 clinical clinical JJ cord-001397-nrq4ncdf 373 35 signs sign NNS cord-001397-nrq4ncdf 373 36 of of IN cord-001397-nrq4ncdf 373 37 illness illness NN cord-001397-nrq4ncdf 374 1 ( ( -LRB- cord-001397-nrq4ncdf 374 2 Mansfield Mansfield NNP cord-001397-nrq4ncdf 374 3 et et NNP cord-001397-nrq4ncdf 374 4 al al NNP cord-001397-nrq4ncdf 374 5 . . NNP cord-001397-nrq4ncdf 374 6 , , , cord-001397-nrq4ncdf 374 7 2009 2009 CD cord-001397-nrq4ncdf 374 8 ; ; : cord-001397-nrq4ncdf 374 9 Klaus Klaus NNP cord-001397-nrq4ncdf 374 10 et et NNP cord-001397-nrq4ncdf 374 11 al al NNP cord-001397-nrq4ncdf 374 12 . . NNP cord-001397-nrq4ncdf 374 13 , , , cord-001397-nrq4ncdf 374 14 2012 2012 CD cord-001397-nrq4ncdf 374 15 ) ) -RRB- cord-001397-nrq4ncdf 374 16 . . . cord-001397-nrq4ncdf 375 1 However however RB cord-001397-nrq4ncdf 375 2 , , , cord-001397-nrq4ncdf 375 3 transmission transmission NN cord-001397-nrq4ncdf 375 4 of of IN cord-001397-nrq4ncdf 375 5 TBEV TBEV NNP cord-001397-nrq4ncdf 375 6 via via IN cord-001397-nrq4ncdf 375 7 milk milk NN cord-001397-nrq4ncdf 375 8 from from IN cord-001397-nrq4ncdf 375 9 these these DT cord-001397-nrq4ncdf 375 10 domesticated domesticate VBN cord-001397-nrq4ncdf 375 11 animals animal NNS cord-001397-nrq4ncdf 376 1 ( ( -LRB- cord-001397-nrq4ncdf 376 2 Fig Fig NNP cord-001397-nrq4ncdf 376 3 . . NNP cord-001397-nrq4ncdf 376 4 1 1 CD cord-001397-nrq4ncdf 376 5 ) ) -RRB- cord-001397-nrq4ncdf 376 6 has have VBZ cord-001397-nrq4ncdf 376 7 been be VBN cord-001397-nrq4ncdf 376 8 documented document VBN cord-001397-nrq4ncdf 376 9 , , , cord-001397-nrq4ncdf 376 10 suggesting suggest VBG cord-001397-nrq4ncdf 376 11 that that IN cord-001397-nrq4ncdf 376 12 virus virus NN cord-001397-nrq4ncdf 376 13 may may MD cord-001397-nrq4ncdf 376 14 persist persist VB cord-001397-nrq4ncdf 376 15 following follow VBG cord-001397-nrq4ncdf 376 16 the the DT cord-001397-nrq4ncdf 376 17 acute acute JJ cord-001397-nrq4ncdf 376 18 viremia viremia NN cord-001397-nrq4ncdf 376 19 in in IN cord-001397-nrq4ncdf 376 20 at at IN cord-001397-nrq4ncdf 376 21 least least JJS cord-001397-nrq4ncdf 376 22 some some DT cord-001397-nrq4ncdf 376 23 instances instance NNS cord-001397-nrq4ncdf 376 24 ( ( -LRB- cord-001397-nrq4ncdf 376 25 Vereta Vereta NNP cord-001397-nrq4ncdf 376 26 et et FW cord-001397-nrq4ncdf 376 27 al al NNP cord-001397-nrq4ncdf 376 28 . . NNP cord-001397-nrq4ncdf 376 29 , , , cord-001397-nrq4ncdf 376 30 1991 1991 CD cord-001397-nrq4ncdf 376 31 ; ; : cord-001397-nrq4ncdf 376 32 Caini Caini NNP cord-001397-nrq4ncdf 376 33 et et NNP cord-001397-nrq4ncdf 376 34 al al NNP cord-001397-nrq4ncdf 376 35 . . NNP cord-001397-nrq4ncdf 376 36 , , , cord-001397-nrq4ncdf 376 37 2012 2012 CD cord-001397-nrq4ncdf 376 38 ; ; . cord-001397-nrq4ncdf 377 1 Hudopisk Hudopisk NNP cord-001397-nrq4ncdf 377 2 et et NNP cord-001397-nrq4ncdf 377 3 al al NNP cord-001397-nrq4ncdf 377 4 . . NNP cord-001397-nrq4ncdf 377 5 , , , cord-001397-nrq4ncdf 377 6 2013 2013 CD cord-001397-nrq4ncdf 377 7 ) ) -RRB- cord-001397-nrq4ncdf 377 8 . . . cord-001397-nrq4ncdf 378 1 Birds bird NNS cord-001397-nrq4ncdf 378 2 and and CC cord-001397-nrq4ncdf 378 3 primates primate NNS cord-001397-nrq4ncdf 378 4 are be VBP cord-001397-nrq4ncdf 378 5 considered consider VBN cord-001397-nrq4ncdf 378 6 to to TO cord-001397-nrq4ncdf 378 7 be be VB cord-001397-nrq4ncdf 378 8 the the DT cord-001397-nrq4ncdf 378 9 primary primary JJ cord-001397-nrq4ncdf 378 10 reservoirs reservoir NNS cord-001397-nrq4ncdf 378 11 of of IN cord-001397-nrq4ncdf 378 12 MBFVs mbfv NNS cord-001397-nrq4ncdf 378 13 . . . cord-001397-nrq4ncdf 379 1 Other other JJ cord-001397-nrq4ncdf 379 2 mammals mammal NNS cord-001397-nrq4ncdf 379 3 are be VBP cord-001397-nrq4ncdf 379 4 generally generally RB cord-001397-nrq4ncdf 379 5 accidental accidental JJ cord-001397-nrq4ncdf 379 6 hosts host NNS cord-001397-nrq4ncdf 379 7 , , , cord-001397-nrq4ncdf 379 8 but but CC cord-001397-nrq4ncdf 379 9 this this DT cord-001397-nrq4ncdf 379 10 may may MD cord-001397-nrq4ncdf 379 11 not not RB cord-001397-nrq4ncdf 379 12 always always RB cord-001397-nrq4ncdf 379 13 be be VB cord-001397-nrq4ncdf 379 14 the the DT cord-001397-nrq4ncdf 379 15 case case NN cord-001397-nrq4ncdf 379 16 , , , cord-001397-nrq4ncdf 379 17 and and CC cord-001397-nrq4ncdf 379 18 when when WRB cord-001397-nrq4ncdf 379 19 viremic viremic NN cord-001397-nrq4ncdf 379 20 , , , cord-001397-nrq4ncdf 379 21 these these DT cord-001397-nrq4ncdf 379 22 domestic domestic JJ cord-001397-nrq4ncdf 379 23 animals animal NNS cord-001397-nrq4ncdf 379 24 are be VBP cord-001397-nrq4ncdf 379 25 able able JJ cord-001397-nrq4ncdf 379 26 to to TO cord-001397-nrq4ncdf 379 27 infect infect VB cord-001397-nrq4ncdf 379 28 mosquitoes mosquito NNS cord-001397-nrq4ncdf 379 29 . . . cord-001397-nrq4ncdf 380 1 For for IN cord-001397-nrq4ncdf 380 2 JEV JEV NNP cord-001397-nrq4ncdf 380 3 , , , cord-001397-nrq4ncdf 380 4 the the DT cord-001397-nrq4ncdf 380 5 major major JJ cord-001397-nrq4ncdf 380 6 amplifying amplify VBG cord-001397-nrq4ncdf 380 7 hosts host NNS cord-001397-nrq4ncdf 380 8 are be VBP cord-001397-nrq4ncdf 380 9 birds bird NNS cord-001397-nrq4ncdf 380 10 and and CC cord-001397-nrq4ncdf 380 11 pigs pig NNS cord-001397-nrq4ncdf 380 12 , , , cord-001397-nrq4ncdf 380 13 which which WDT cord-001397-nrq4ncdf 380 14 attain attain VBP cord-001397-nrq4ncdf 380 15 high high JJ cord-001397-nrq4ncdf 380 16 levels level NNS cord-001397-nrq4ncdf 380 17 of of IN cord-001397-nrq4ncdf 380 18 viremia viremia NN cord-001397-nrq4ncdf 380 19 . . . cord-001397-nrq4ncdf 381 1 They -PRON- PRP cord-001397-nrq4ncdf 381 2 provide provide VBP cord-001397-nrq4ncdf 381 3 a a DT cord-001397-nrq4ncdf 381 4 source source NN cord-001397-nrq4ncdf 381 5 of of IN cord-001397-nrq4ncdf 381 6 infection infection NN cord-001397-nrq4ncdf 381 7 for for IN cord-001397-nrq4ncdf 381 8 the the DT cord-001397-nrq4ncdf 381 9 mosquito mosquito NN cord-001397-nrq4ncdf 381 10 species specie NNS cord-001397-nrq4ncdf 381 11 that that WDT cord-001397-nrq4ncdf 381 12 subsequently subsequently RB cord-001397-nrq4ncdf 381 13 transmit transmit VBP cord-001397-nrq4ncdf 381 14 JEV JEV NNP cord-001397-nrq4ncdf 381 15 to to IN cord-001397-nrq4ncdf 381 16 humans human NNS cord-001397-nrq4ncdf 381 17 ( ( -LRB- cord-001397-nrq4ncdf 381 18 Hukkanen Hukkanen NNP cord-001397-nrq4ncdf 381 19 et et FW cord-001397-nrq4ncdf 381 20 al al NNP cord-001397-nrq4ncdf 381 21 . . NNP cord-001397-nrq4ncdf 381 22 , , , cord-001397-nrq4ncdf 381 23 2006 2006 CD cord-001397-nrq4ncdf 381 24 ; ; : cord-001397-nrq4ncdf 381 25 van van NNP cord-001397-nrq4ncdf 381 26 den den NNP cord-001397-nrq4ncdf 381 27 Hurk Hurk NNP cord-001397-nrq4ncdf 381 28 et et NNP cord-001397-nrq4ncdf 381 29 al al NNP cord-001397-nrq4ncdf 381 30 . . NNP cord-001397-nrq4ncdf 381 31 , , , cord-001397-nrq4ncdf 381 32 2009 2009 CD cord-001397-nrq4ncdf 381 33 ) ) -RRB- cord-001397-nrq4ncdf 381 34 . . . cord-001397-nrq4ncdf 382 1 JEV JEV NNP cord-001397-nrq4ncdf 382 2 control control NN cord-001397-nrq4ncdf 382 3 has have VBZ cord-001397-nrq4ncdf 382 4 been be VBN cord-001397-nrq4ncdf 382 5 achieved achieve VBN cord-001397-nrq4ncdf 382 6 through through IN cord-001397-nrq4ncdf 382 7 vaccination vaccination NN cord-001397-nrq4ncdf 382 8 of of IN cord-001397-nrq4ncdf 382 9 pigs pig NNS cord-001397-nrq4ncdf 382 10 and and CC cord-001397-nrq4ncdf 382 11 humans human NNS cord-001397-nrq4ncdf 382 12 in in IN cord-001397-nrq4ncdf 382 13 Korea Korea NNP cord-001397-nrq4ncdf 382 14 , , , cord-001397-nrq4ncdf 382 15 Japan Japan NNP cord-001397-nrq4ncdf 382 16 , , , cord-001397-nrq4ncdf 382 17 and and CC cord-001397-nrq4ncdf 382 18 Taiwan Taiwan NNP cord-001397-nrq4ncdf 382 19 ( ( -LRB- cord-001397-nrq4ncdf 382 20 Igarashi Igarashi NNP cord-001397-nrq4ncdf 382 21 , , , cord-001397-nrq4ncdf 382 22 2002 2002 CD cord-001397-nrq4ncdf 382 23 ) ) -RRB- cord-001397-nrq4ncdf 382 24 while while IN cord-001397-nrq4ncdf 382 25 horses horse NNS cord-001397-nrq4ncdf 382 26 are be VBP cord-001397-nrq4ncdf 382 27 considered consider VBN cord-001397-nrq4ncdf 382 28 dead dead JJ cord-001397-nrq4ncdf 382 29 - - HYPH cord-001397-nrq4ncdf 382 30 end end NN cord-001397-nrq4ncdf 382 31 hosts host NNS cord-001397-nrq4ncdf 382 32 of of IN cord-001397-nrq4ncdf 382 33 JEV JEV NNP cord-001397-nrq4ncdf 382 34 infection infection NN cord-001397-nrq4ncdf 382 35 due due IN cord-001397-nrq4ncdf 382 36 to to IN cord-001397-nrq4ncdf 382 37 a a DT cord-001397-nrq4ncdf 382 38 very very RB cord-001397-nrq4ncdf 382 39 low low JJ cord-001397-nrq4ncdf 382 40 level level NN cord-001397-nrq4ncdf 382 41 of of IN cord-001397-nrq4ncdf 382 42 viremia viremia NN cord-001397-nrq4ncdf 382 43 . . . cord-001397-nrq4ncdf 383 1 In in IN cord-001397-nrq4ncdf 383 2 geographic geographic JJ cord-001397-nrq4ncdf 383 3 regions region NNS cord-001397-nrq4ncdf 383 4 where where WRB cord-001397-nrq4ncdf 383 5 pig pig NN cord-001397-nrq4ncdf 383 6 populations population NNS cord-001397-nrq4ncdf 383 7 are be VBP cord-001397-nrq4ncdf 383 8 low low JJ cord-001397-nrq4ncdf 383 9 , , , cord-001397-nrq4ncdf 383 10 swine swine NN cord-001397-nrq4ncdf 383 11 may may MD cord-001397-nrq4ncdf 383 12 not not RB cord-001397-nrq4ncdf 383 13 be be VB cord-001397-nrq4ncdf 383 14 important important JJ cord-001397-nrq4ncdf 383 15 for for IN cord-001397-nrq4ncdf 383 16 zoonotic zoonotic JJ cord-001397-nrq4ncdf 383 17 transmission transmission NN cord-001397-nrq4ncdf 383 18 of of IN cord-001397-nrq4ncdf 383 19 JEV JEV NNP cord-001397-nrq4ncdf 383 20 . . . cord-001397-nrq4ncdf 384 1 Herons heron NNS cord-001397-nrq4ncdf 384 2 and and CC cord-001397-nrq4ncdf 384 3 egrets egret NNS cord-001397-nrq4ncdf 384 4 are be VBP cord-001397-nrq4ncdf 384 5 important important JJ cord-001397-nrq4ncdf 384 6 JEV JEV NNP cord-001397-nrq4ncdf 384 7 - - HYPH cord-001397-nrq4ncdf 384 8 amplifying amplify VBG cord-001397-nrq4ncdf 384 9 hosts host NNS cord-001397-nrq4ncdf 384 10 and and CC cord-001397-nrq4ncdf 384 11 source source NN cord-001397-nrq4ncdf 384 12 of of IN cord-001397-nrq4ncdf 384 13 infection infection NN cord-001397-nrq4ncdf 384 14 for for IN cord-001397-nrq4ncdf 384 15 mosquito mosquito NN cord-001397-nrq4ncdf 384 16 species specie NNS cord-001397-nrq4ncdf 384 17 that that WDT cord-001397-nrq4ncdf 384 18 transmit transmit VBP cord-001397-nrq4ncdf 384 19 JEV JEV NNP cord-001397-nrq4ncdf 384 20 to to IN cord-001397-nrq4ncdf 384 21 humans human NNS cord-001397-nrq4ncdf 384 22 ( ( -LRB- cord-001397-nrq4ncdf 384 23 Nemeth Nemeth NNP cord-001397-nrq4ncdf 384 24 et et NNP cord-001397-nrq4ncdf 384 25 al al NNP cord-001397-nrq4ncdf 384 26 . . NNP cord-001397-nrq4ncdf 384 27 , , , cord-001397-nrq4ncdf 384 28 2009 2009 CD cord-001397-nrq4ncdf 384 29 ) ) -RRB- cord-001397-nrq4ncdf 384 30 . . . cord-001397-nrq4ncdf 385 1 Wild wild NN cord-001397-nrq4ncdf 385 2 - - HYPH cord-001397-nrq4ncdf 385 3 caught catch VBN cord-001397-nrq4ncdf 385 4 pigeons pigeon NNS cord-001397-nrq4ncdf 385 5 were be VBD cord-001397-nrq4ncdf 385 6 shown show VBN cord-001397-nrq4ncdf 385 7 to to TO cord-001397-nrq4ncdf 385 8 have have VB cord-001397-nrq4ncdf 385 9 antibodies antibody NNS cord-001397-nrq4ncdf 385 10 that that WDT cord-001397-nrq4ncdf 385 11 persist persist VBP cord-001397-nrq4ncdf 385 12 for for IN cord-001397-nrq4ncdf 385 13 up up IN cord-001397-nrq4ncdf 385 14 to to TO cord-001397-nrq4ncdf 385 15 15 15 CD cord-001397-nrq4ncdf 385 16 months month NNS cord-001397-nrq4ncdf 385 17 . . . cord-001397-nrq4ncdf 386 1 It -PRON- PRP cord-001397-nrq4ncdf 386 2 is be VBZ cord-001397-nrq4ncdf 386 3 not not RB cord-001397-nrq4ncdf 386 4 clear clear JJ cord-001397-nrq4ncdf 386 5 whether whether IN cord-001397-nrq4ncdf 386 6 the the DT cord-001397-nrq4ncdf 386 7 antibody antibody NN cord-001397-nrq4ncdf 386 8 persistence persistence NN cord-001397-nrq4ncdf 386 9 is be VBZ cord-001397-nrq4ncdf 386 10 associated associate VBN cord-001397-nrq4ncdf 386 11 with with IN cord-001397-nrq4ncdf 386 12 viral viral JJ cord-001397-nrq4ncdf 386 13 persistence persistence NN cord-001397-nrq4ncdf 386 14 . . . cord-001397-nrq4ncdf 387 1 Although although IN cord-001397-nrq4ncdf 387 2 various various JJ cord-001397-nrq4ncdf 387 3 bird bird NN cord-001397-nrq4ncdf 387 4 species specie NNS cord-001397-nrq4ncdf 387 5 do do VBP cord-001397-nrq4ncdf 387 6 play play VB cord-001397-nrq4ncdf 387 7 a a DT cord-001397-nrq4ncdf 387 8 prominent prominent JJ cord-001397-nrq4ncdf 387 9 role role NN cord-001397-nrq4ncdf 387 10 in in IN cord-001397-nrq4ncdf 387 11 JEV JEV NNP cord-001397-nrq4ncdf 387 12 infection infection NN cord-001397-nrq4ncdf 387 13 , , , cord-001397-nrq4ncdf 387 14 evidence evidence NN cord-001397-nrq4ncdf 387 15 of of IN cord-001397-nrq4ncdf 387 16 birds bird NNS cord-001397-nrq4ncdf 387 17 as as IN cord-001397-nrq4ncdf 387 18 a a DT cord-001397-nrq4ncdf 387 19 source source NN cord-001397-nrq4ncdf 387 20 of of IN cord-001397-nrq4ncdf 387 21 persistent persistent JJ cord-001397-nrq4ncdf 387 22 infection infection NN cord-001397-nrq4ncdf 387 23 is be VBZ cord-001397-nrq4ncdf 387 24 less less RBR cord-001397-nrq4ncdf 387 25 certain certain JJ cord-001397-nrq4ncdf 387 26 . . . cord-001397-nrq4ncdf 388 1 In in IN cord-001397-nrq4ncdf 388 2 some some DT cord-001397-nrq4ncdf 388 3 instances instance NNS cord-001397-nrq4ncdf 388 4 , , , cord-001397-nrq4ncdf 388 5 birds bird NNS cord-001397-nrq4ncdf 388 6 can can MD cord-001397-nrq4ncdf 388 7 acquire acquire VB cord-001397-nrq4ncdf 388 8 JEV JEV NNP cord-001397-nrq4ncdf 388 9 viremia viremia NN cord-001397-nrq4ncdf 388 10 and and CC cord-001397-nrq4ncdf 388 11 then then RB cord-001397-nrq4ncdf 388 12 fail fail VB cord-001397-nrq4ncdf 388 13 to to TO cord-001397-nrq4ncdf 388 14 develop develop VB cord-001397-nrq4ncdf 388 15 or or CC cord-001397-nrq4ncdf 388 16 lose lose VB cord-001397-nrq4ncdf 388 17 neutralizing neutralize VBG cord-001397-nrq4ncdf 388 18 antibodies antibody NNS cord-001397-nrq4ncdf 388 19 . . . cord-001397-nrq4ncdf 389 1 Birds bird NNS cord-001397-nrq4ncdf 389 2 are be VBP cord-001397-nrq4ncdf 389 3 also also RB cord-001397-nrq4ncdf 389 4 excellent excellent JJ cord-001397-nrq4ncdf 389 5 amplifying amplify VBG cord-001397-nrq4ncdf 389 6 hosts host NNS cord-001397-nrq4ncdf 389 7 for for IN cord-001397-nrq4ncdf 389 8 WNV WNV NNP cord-001397-nrq4ncdf 389 9 , , , cord-001397-nrq4ncdf 389 10 and and CC cord-001397-nrq4ncdf 389 11 migratory migratory JJ cord-001397-nrq4ncdf 389 12 birds bird NNS cord-001397-nrq4ncdf 389 13 can can MD cord-001397-nrq4ncdf 389 14 move move VB cord-001397-nrq4ncdf 389 15 the the DT cord-001397-nrq4ncdf 389 16 viruses virus NNS cord-001397-nrq4ncdf 389 17 to to IN cord-001397-nrq4ncdf 389 18 different different JJ cord-001397-nrq4ncdf 389 19 areas area NNS cord-001397-nrq4ncdf 389 20 because because IN cord-001397-nrq4ncdf 389 21 they -PRON- PRP cord-001397-nrq4ncdf 389 22 become become VBP cord-001397-nrq4ncdf 389 23 viremic viremic JJ cord-001397-nrq4ncdf 389 24 for for IN cord-001397-nrq4ncdf 389 25 several several JJ cord-001397-nrq4ncdf 389 26 days day NNS cord-001397-nrq4ncdf 389 27 . . . cord-001397-nrq4ncdf 390 1 Near near IN cord-001397-nrq4ncdf 390 2 100 100 CD cord-001397-nrq4ncdf 390 3 % % NN cord-001397-nrq4ncdf 390 4 mortality mortality NN cord-001397-nrq4ncdf 390 5 is be VBZ cord-001397-nrq4ncdf 390 6 associated associate VBN cord-001397-nrq4ncdf 390 7 with with IN cord-001397-nrq4ncdf 390 8 natural natural JJ cord-001397-nrq4ncdf 390 9 or or CC cord-001397-nrq4ncdf 390 10 experimental experimental JJ cord-001397-nrq4ncdf 390 11 WNV WNV NNP cord-001397-nrq4ncdf 390 12 infection infection NN cord-001397-nrq4ncdf 390 13 in in IN cord-001397-nrq4ncdf 390 14 birds bird NNS cord-001397-nrq4ncdf 390 15 , , , cord-001397-nrq4ncdf 390 16 such such JJ cord-001397-nrq4ncdf 390 17 as as IN cord-001397-nrq4ncdf 390 18 American american JJ cord-001397-nrq4ncdf 390 19 crows crow NNS cord-001397-nrq4ncdf 390 20 ( ( -LRB- cord-001397-nrq4ncdf 390 21 Corvus Corvus NNP cord-001397-nrq4ncdf 390 22 brachyrhynchos brachyrhynchos NNP cord-001397-nrq4ncdf 390 23 ) ) -RRB- cord-001397-nrq4ncdf 390 24 , , , cord-001397-nrq4ncdf 390 25 blue blue JJ cord-001397-nrq4ncdf 390 26 jays jays NNPS cord-001397-nrq4ncdf 390 27 ( ( -LRB- cord-001397-nrq4ncdf 390 28 Cyanocitta Cyanocitta NNP cord-001397-nrq4ncdf 390 29 cristata cristata NNP cord-001397-nrq4ncdf 390 30 ) ) -RRB- cord-001397-nrq4ncdf 390 31 , , , cord-001397-nrq4ncdf 390 32 and and CC cord-001397-nrq4ncdf 390 33 greater great JJR cord-001397-nrq4ncdf 390 34 sage sage NN cord-001397-nrq4ncdf 390 35 - - HYPH cord-001397-nrq4ncdf 390 36 grouse grouse NN cord-001397-nrq4ncdf 391 1 ( ( -LRB- cord-001397-nrq4ncdf 391 2 Centrocercus Centrocercus NNP cord-001397-nrq4ncdf 391 3 urophasianus urophasianus NNP cord-001397-nrq4ncdf 391 4 ; ; : cord-001397-nrq4ncdf 391 5 Steele Steele NNP cord-001397-nrq4ncdf 391 6 et et NNP cord-001397-nrq4ncdf 391 7 al al NNP cord-001397-nrq4ncdf 391 8 . . NNP cord-001397-nrq4ncdf 391 9 , , , cord-001397-nrq4ncdf 391 10 2000 2000 CD cord-001397-nrq4ncdf 391 11 ; ; : cord-001397-nrq4ncdf 392 1 Komar Komar NNP cord-001397-nrq4ncdf 392 2 et et NNP cord-001397-nrq4ncdf 392 3 al al NNP cord-001397-nrq4ncdf 392 4 . . NNP cord-001397-nrq4ncdf 392 5 , , , cord-001397-nrq4ncdf 392 6 2003 2003 CD cord-001397-nrq4ncdf 393 1 ; ; : cord-001397-nrq4ncdf 393 2 Clark Clark NNP cord-001397-nrq4ncdf 393 3 et et NNP cord-001397-nrq4ncdf 393 4 al al NNP cord-001397-nrq4ncdf 393 5 . . NNP cord-001397-nrq4ncdf 393 6 , , , cord-001397-nrq4ncdf 393 7 2006 2006 CD cord-001397-nrq4ncdf 393 8 ) ) -RRB- cord-001397-nrq4ncdf 393 9 , , , cord-001397-nrq4ncdf 393 10 but but CC cord-001397-nrq4ncdf 393 11 some some DT cord-001397-nrq4ncdf 393 12 birds bird NNS cord-001397-nrq4ncdf 393 13 are be VBP cord-001397-nrq4ncdf 393 14 able able JJ cord-001397-nrq4ncdf 393 15 to to TO cord-001397-nrq4ncdf 393 16 carry carry VB cord-001397-nrq4ncdf 393 17 the the DT cord-001397-nrq4ncdf 393 18 virus virus NN cord-001397-nrq4ncdf 393 19 for for IN cord-001397-nrq4ncdf 393 20 a a DT cord-001397-nrq4ncdf 393 21 longer long JJR cord-001397-nrq4ncdf 393 22 time time NN cord-001397-nrq4ncdf 393 23 before before IN cord-001397-nrq4ncdf 393 24 they -PRON- PRP cord-001397-nrq4ncdf 393 25 develop develop VBP cord-001397-nrq4ncdf 393 26 antibodies antibody NNS cord-001397-nrq4ncdf 393 27 or or CC cord-001397-nrq4ncdf 393 28 succumb succumb VB cord-001397-nrq4ncdf 393 29 to to IN cord-001397-nrq4ncdf 393 30 disease disease NN cord-001397-nrq4ncdf 393 31 ( ( -LRB- cord-001397-nrq4ncdf 393 32 McKenzie McKenzie NNP cord-001397-nrq4ncdf 393 33 & & CC cord-001397-nrq4ncdf 393 34 Goulet Goulet NNP cord-001397-nrq4ncdf 393 35 , , , cord-001397-nrq4ncdf 393 36 2010 2010 CD cord-001397-nrq4ncdf 393 37 ) ) -RRB- cord-001397-nrq4ncdf 393 38 . . . cord-001397-nrq4ncdf 394 1 For for IN cord-001397-nrq4ncdf 394 2 instance instance NN cord-001397-nrq4ncdf 394 3 , , , cord-001397-nrq4ncdf 394 4 a a DT cord-001397-nrq4ncdf 394 5 combined combine VBN cord-001397-nrq4ncdf 394 6 37 37 CD cord-001397-nrq4ncdf 394 7 % % NN cord-001397-nrq4ncdf 394 8 of of IN cord-001397-nrq4ncdf 394 9 house house NN cord-001397-nrq4ncdf 394 10 sparrows sparrow NNS cord-001397-nrq4ncdf 394 11 that that WDT cord-001397-nrq4ncdf 394 12 were be VBD cord-001397-nrq4ncdf 394 13 either either CC cord-001397-nrq4ncdf 394 14 naturally naturally RB cord-001397-nrq4ncdf 394 15 or or CC cord-001397-nrq4ncdf 394 16 experimentally experimentally RB cord-001397-nrq4ncdf 394 17 infected infect VBN cord-001397-nrq4ncdf 394 18 with with IN cord-001397-nrq4ncdf 394 19 WNV WNV NNP cord-001397-nrq4ncdf 394 20 tested test VBD cord-001397-nrq4ncdf 394 21 positive positive JJ cord-001397-nrq4ncdf 394 22 for for IN cord-001397-nrq4ncdf 394 23 WNV WNV NNP cord-001397-nrq4ncdf 394 24 RNA RNA NNP cord-001397-nrq4ncdf 394 25 by by IN cord-001397-nrq4ncdf 394 26 RT RT NNP cord-001397-nrq4ncdf 394 27 - - HYPH cord-001397-nrq4ncdf 394 28 PCR PCR NNP cord-001397-nrq4ncdf 394 29 ( ( -LRB- cord-001397-nrq4ncdf 394 30 Wheeler Wheeler NNP cord-001397-nrq4ncdf 394 31 et et NNP cord-001397-nrq4ncdf 394 32 al al NNP cord-001397-nrq4ncdf 394 33 . . NNP cord-001397-nrq4ncdf 394 34 , , , cord-001397-nrq4ncdf 394 35 2012 2012 CD cord-001397-nrq4ncdf 394 36 ) ) -RRB- cord-001397-nrq4ncdf 394 37 . . . cord-001397-nrq4ncdf 395 1 In in IN cord-001397-nrq4ncdf 395 2 the the DT cord-001397-nrq4ncdf 395 3 same same JJ cord-001397-nrq4ncdf 395 4 study study NN cord-001397-nrq4ncdf 395 5 , , , cord-001397-nrq4ncdf 395 6 Wheeler Wheeler NNP cord-001397-nrq4ncdf 395 7 et et NNP cord-001397-nrq4ncdf 395 8 al al NNP cord-001397-nrq4ncdf 395 9 . . . cord-001397-nrq4ncdf 396 1 ( ( -LRB- cord-001397-nrq4ncdf 396 2 2012 2012 CD cord-001397-nrq4ncdf 396 3 ) ) -RRB- cord-001397-nrq4ncdf 396 4 showed show VBD cord-001397-nrq4ncdf 396 5 that that IN cord-001397-nrq4ncdf 396 6 97 97 CD cord-001397-nrq4ncdf 396 7 % % NN cord-001397-nrq4ncdf 396 8 and and CC cord-001397-nrq4ncdf 396 9 100 100 CD cord-001397-nrq4ncdf 396 10 % % NN cord-001397-nrq4ncdf 396 11 of of IN cord-001397-nrq4ncdf 396 12 WNV WNV NNP cord-001397-nrq4ncdf 396 13 - - HYPH cord-001397-nrq4ncdf 396 14 infected infect VBN cord-001397-nrq4ncdf 396 15 house house NN cord-001397-nrq4ncdf 396 16 sparrows sparrow NNS cord-001397-nrq4ncdf 396 17 and and CC cord-001397-nrq4ncdf 396 18 finches finch NNS cord-001397-nrq4ncdf 396 19 , , , cord-001397-nrq4ncdf 396 20 respectively respectively RB cord-001397-nrq4ncdf 396 21 , , , cord-001397-nrq4ncdf 396 22 seroconverted seroconverte VBD cord-001397-nrq4ncdf 396 23 following follow VBG cord-001397-nrq4ncdf 396 24 exposure exposure NN cord-001397-nrq4ncdf 396 25 to to IN cord-001397-nrq4ncdf 396 26 WNV WNV NNP cord-001397-nrq4ncdf 396 27 . . . cord-001397-nrq4ncdf 397 1 Birds bird NNS cord-001397-nrq4ncdf 397 2 that that WDT cord-001397-nrq4ncdf 397 3 develop develop VBP cord-001397-nrq4ncdf 397 4 neutralizing neutralize VBG cord-001397-nrq4ncdf 397 5 anti anti JJ cord-001397-nrq4ncdf 397 6 - - JJ cord-001397-nrq4ncdf 397 7 WNV WNV NNP cord-001397-nrq4ncdf 397 8 antibodies antibody NNS cord-001397-nrq4ncdf 397 9 are be VBP cord-001397-nrq4ncdf 397 10 protected protect VBN cord-001397-nrq4ncdf 397 11 from from IN cord-001397-nrq4ncdf 397 12 reinfection reinfection NN cord-001397-nrq4ncdf 397 13 ( ( -LRB- cord-001397-nrq4ncdf 397 14 Nemeth Nemeth NNP cord-001397-nrq4ncdf 397 15 et et NNP cord-001397-nrq4ncdf 397 16 al al NNP cord-001397-nrq4ncdf 397 17 . . NNP cord-001397-nrq4ncdf 397 18 , , , cord-001397-nrq4ncdf 397 19 2009 2009 CD cord-001397-nrq4ncdf 397 20 ) ) -RRB- cord-001397-nrq4ncdf 397 21 , , , cord-001397-nrq4ncdf 397 22 suggesting suggest VBG cord-001397-nrq4ncdf 397 23 total total JJ cord-001397-nrq4ncdf 397 24 virus virus NN cord-001397-nrq4ncdf 397 25 clearance clearance NN cord-001397-nrq4ncdf 397 26 in in IN cord-001397-nrq4ncdf 397 27 seroconverted seroconverte VBN cord-001397-nrq4ncdf 397 28 birds bird NNS cord-001397-nrq4ncdf 397 29 , , , cord-001397-nrq4ncdf 397 30 and and CC cord-001397-nrq4ncdf 397 31 antibodies antibody NNS cord-001397-nrq4ncdf 397 32 against against IN cord-001397-nrq4ncdf 397 33 WNV WNV NNP cord-001397-nrq4ncdf 397 34 have have VBP cord-001397-nrq4ncdf 397 35 been be VBN cord-001397-nrq4ncdf 397 36 found find VBN cord-001397-nrq4ncdf 397 37 in in IN cord-001397-nrq4ncdf 397 38 wild wild JJ cord-001397-nrq4ncdf 397 39 birds bird NNS cord-001397-nrq4ncdf 397 40 , , , cord-001397-nrq4ncdf 397 41 suggesting suggest VBG cord-001397-nrq4ncdf 397 42 exposure exposure NN cord-001397-nrq4ncdf 397 43 to to IN cord-001397-nrq4ncdf 397 44 WNV WNV NNP cord-001397-nrq4ncdf 397 45 . . . cord-001397-nrq4ncdf 398 1 Early early JJ cord-001397-nrq4ncdf 398 2 demonstration demonstration NN cord-001397-nrq4ncdf 398 3 of of IN cord-001397-nrq4ncdf 398 4 WNV WNV NNP cord-001397-nrq4ncdf 398 5 persistence persistence NN cord-001397-nrq4ncdf 398 6 was be VBD cord-001397-nrq4ncdf 398 7 described describe VBN cord-001397-nrq4ncdf 398 8 in in IN cord-001397-nrq4ncdf 398 9 blue blue JJ cord-001397-nrq4ncdf 398 10 - - HYPH cord-001397-nrq4ncdf 398 11 gray gray JJ cord-001397-nrq4ncdf 398 12 pigeons pigeon NNS cord-001397-nrq4ncdf 398 13 , , , cord-001397-nrq4ncdf 398 14 from from IN cord-001397-nrq4ncdf 398 15 which which WDT cord-001397-nrq4ncdf 398 16 virus virus NN cord-001397-nrq4ncdf 398 17 was be VBD cord-001397-nrq4ncdf 398 18 isolated isolate VBN cord-001397-nrq4ncdf 398 19 up up IN cord-001397-nrq4ncdf 398 20 to to TO cord-001397-nrq4ncdf 398 21 100 100 CD cord-001397-nrq4ncdf 398 22 days day NNS cord-001397-nrq4ncdf 398 23 postinfection postinfection NN cord-001397-nrq4ncdf 398 24 , , , cord-001397-nrq4ncdf 398 25 and and CC cord-001397-nrq4ncdf 398 26 viral viral JJ cord-001397-nrq4ncdf 398 27 antigen antigen NN cord-001397-nrq4ncdf 398 28 could could MD cord-001397-nrq4ncdf 398 29 be be VB cord-001397-nrq4ncdf 398 30 detected detect VBN cord-001397-nrq4ncdf 398 31 in in IN cord-001397-nrq4ncdf 398 32 liver liver NN cord-001397-nrq4ncdf 398 33 tissue tissue NN cord-001397-nrq4ncdf 398 34 for for IN cord-001397-nrq4ncdf 398 35 up up IN cord-001397-nrq4ncdf 398 36 to to TO cord-001397-nrq4ncdf 398 37 180 180 CD cord-001397-nrq4ncdf 398 38 days day NNS cord-001397-nrq4ncdf 398 39 ( ( -LRB- cord-001397-nrq4ncdf 398 40 Ruiz Ruiz NNP cord-001397-nrq4ncdf 398 41 et et NNP cord-001397-nrq4ncdf 398 42 al al NNP cord-001397-nrq4ncdf 398 43 . . NNP cord-001397-nrq4ncdf 398 44 , , , cord-001397-nrq4ncdf 398 45 2010 2010 CD cord-001397-nrq4ncdf 398 46 ) ) -RRB- cord-001397-nrq4ncdf 398 47 . . . cord-001397-nrq4ncdf 399 1 American american JJ cord-001397-nrq4ncdf 399 2 robins robin NNS cord-001397-nrq4ncdf 399 3 ( ( -LRB- cord-001397-nrq4ncdf 399 4 Tardus Tardus NNP cord-001397-nrq4ncdf 399 5 migratorius migratorius NN cord-001397-nrq4ncdf 399 6 ) ) -RRB- cord-001397-nrq4ncdf 399 7 are be VBP cord-001397-nrq4ncdf 399 8 known know VBN cord-001397-nrq4ncdf 399 9 to to TO cord-001397-nrq4ncdf 399 10 be be VB cord-001397-nrq4ncdf 399 11 competent competent JJ cord-001397-nrq4ncdf 399 12 reservoirs reservoir NNS cord-001397-nrq4ncdf 399 13 of of IN cord-001397-nrq4ncdf 399 14 WNV WNV NNP cord-001397-nrq4ncdf 399 15 and and CC cord-001397-nrq4ncdf 399 16 SLEV SLEV NNP cord-001397-nrq4ncdf 400 1 ( ( -LRB- cord-001397-nrq4ncdf 400 2 Kilpatrick Kilpatrick NNP cord-001397-nrq4ncdf 400 3 et et NNP cord-001397-nrq4ncdf 400 4 al al NNP cord-001397-nrq4ncdf 400 5 . . NNP cord-001397-nrq4ncdf 400 6 , , , cord-001397-nrq4ncdf 400 7 2006 2006 CD cord-001397-nrq4ncdf 400 8 ) ) -RRB- cord-001397-nrq4ncdf 400 9 . . . cord-001397-nrq4ncdf 401 1 WNV WNV NNP cord-001397-nrq4ncdf 401 2 persistence persistence NN cord-001397-nrq4ncdf 401 3 was be VBD cord-001397-nrq4ncdf 401 4 also also RB cord-001397-nrq4ncdf 401 5 demonstrated demonstrate VBN cord-001397-nrq4ncdf 401 6 by by IN cord-001397-nrq4ncdf 401 7 the the DT cord-001397-nrq4ncdf 401 8 detection detection NN cord-001397-nrq4ncdf 401 9 of of IN cord-001397-nrq4ncdf 401 10 viral viral JJ cord-001397-nrq4ncdf 401 11 RNA RNA NNP cord-001397-nrq4ncdf 401 12 in in IN cord-001397-nrq4ncdf 401 13 the the DT cord-001397-nrq4ncdf 401 14 presence presence NN cord-001397-nrq4ncdf 401 15 of of IN cord-001397-nrq4ncdf 401 16 antibody antibody NN cord-001397-nrq4ncdf 401 17 for for IN cord-001397-nrq4ncdf 401 18 up up IN cord-001397-nrq4ncdf 401 19 to to TO cord-001397-nrq4ncdf 401 20 36 36 CD cord-001397-nrq4ncdf 401 21 weeks week NNS cord-001397-nrq4ncdf 401 22 in in IN cord-001397-nrq4ncdf 401 23 spleens spleen NNS cord-001397-nrq4ncdf 401 24 of of IN cord-001397-nrq4ncdf 401 25 naturally naturally RB cord-001397-nrq4ncdf 401 26 infected infect VBN cord-001397-nrq4ncdf 401 27 house house NN cord-001397-nrq4ncdf 401 28 sparrows sparrow NNS cord-001397-nrq4ncdf 401 29 and and CC cord-001397-nrq4ncdf 401 30 finches finch NNS cord-001397-nrq4ncdf 401 31 ( ( -LRB- cord-001397-nrq4ncdf 401 32 Wheeler Wheeler NNP cord-001397-nrq4ncdf 401 33 et et NNP cord-001397-nrq4ncdf 401 34 al al NNP cord-001397-nrq4ncdf 401 35 . . NNP cord-001397-nrq4ncdf 401 36 , , , cord-001397-nrq4ncdf 401 37 2012 2012 CD cord-001397-nrq4ncdf 401 38 ) ) -RRB- cord-001397-nrq4ncdf 401 39 . . . cord-001397-nrq4ncdf 402 1 Taken take VBN cord-001397-nrq4ncdf 402 2 together together RB cord-001397-nrq4ncdf 402 3 , , , cord-001397-nrq4ncdf 402 4 it -PRON- PRP cord-001397-nrq4ncdf 402 5 seems seem VBZ cord-001397-nrq4ncdf 402 6 that that IN cord-001397-nrq4ncdf 402 7 there there EX cord-001397-nrq4ncdf 402 8 is be VBZ cord-001397-nrq4ncdf 402 9 decent decent JJ cord-001397-nrq4ncdf 402 10 evidence evidence NN cord-001397-nrq4ncdf 402 11 for for IN cord-001397-nrq4ncdf 402 12 persistent persistent JJ cord-001397-nrq4ncdf 402 13 infection infection NN cord-001397-nrq4ncdf 402 14 by by IN cord-001397-nrq4ncdf 402 15 WNV WNV NNP cord-001397-nrq4ncdf 402 16 in in IN cord-001397-nrq4ncdf 402 17 some some DT cord-001397-nrq4ncdf 402 18 bird bird NN cord-001397-nrq4ncdf 402 19 species specie NNS cord-001397-nrq4ncdf 402 20 . . . cord-001397-nrq4ncdf 403 1 However however RB cord-001397-nrq4ncdf 403 2 , , , cord-001397-nrq4ncdf 403 3 many many JJ cord-001397-nrq4ncdf 403 4 details detail NNS cord-001397-nrq4ncdf 403 5 about about IN cord-001397-nrq4ncdf 403 6 the the DT cord-001397-nrq4ncdf 403 7 biology biology NN cord-001397-nrq4ncdf 403 8 of of IN cord-001397-nrq4ncdf 403 9 persistence persistence NN cord-001397-nrq4ncdf 403 10 remain remain VBP cord-001397-nrq4ncdf 403 11 to to TO cord-001397-nrq4ncdf 403 12 be be VB cord-001397-nrq4ncdf 403 13 studied study VBN cord-001397-nrq4ncdf 403 14 . . . cord-001397-nrq4ncdf 404 1 Antibodies antibody NNS cord-001397-nrq4ncdf 404 2 to to IN cord-001397-nrq4ncdf 404 3 various various JJ cord-001397-nrq4ncdf 404 4 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 404 5 , , , cord-001397-nrq4ncdf 404 6 such such JJ cord-001397-nrq4ncdf 404 7 as as IN cord-001397-nrq4ncdf 404 8 SLEV SLEV NNP cord-001397-nrq4ncdf 404 9 , , , cord-001397-nrq4ncdf 404 10 POWV POWV NNP cord-001397-nrq4ncdf 404 11 , , , cord-001397-nrq4ncdf 404 12 JEV JEV NNP cord-001397-nrq4ncdf 404 13 , , , cord-001397-nrq4ncdf 404 14 and and CC cord-001397-nrq4ncdf 404 15 WNV WNV NNP cord-001397-nrq4ncdf 404 16 , , , cord-001397-nrq4ncdf 404 17 have have VBP cord-001397-nrq4ncdf 404 18 been be VBN cord-001397-nrq4ncdf 404 19 identified identify VBN cord-001397-nrq4ncdf 404 20 in in IN cord-001397-nrq4ncdf 404 21 chelonians chelonians NNP cord-001397-nrq4ncdf 404 22 , , , cord-001397-nrq4ncdf 404 23 snakes snake NNS cord-001397-nrq4ncdf 404 24 , , , cord-001397-nrq4ncdf 404 25 and and CC cord-001397-nrq4ncdf 404 26 crocodiles crocodile NNS cord-001397-nrq4ncdf 404 27 in in IN cord-001397-nrq4ncdf 404 28 different different JJ cord-001397-nrq4ncdf 404 29 geographic geographic JJ cord-001397-nrq4ncdf 404 30 locations location NNS cord-001397-nrq4ncdf 404 31 ( ( -LRB- cord-001397-nrq4ncdf 404 32 Steinman Steinman NNP cord-001397-nrq4ncdf 404 33 et et NNP cord-001397-nrq4ncdf 404 34 al al NNP cord-001397-nrq4ncdf 404 35 . . NNP cord-001397-nrq4ncdf 404 36 , , , cord-001397-nrq4ncdf 404 37 2003 2003 CD cord-001397-nrq4ncdf 404 38 ; ; : cord-001397-nrq4ncdf 404 39 Marschang Marschang NNP cord-001397-nrq4ncdf 404 40 , , , cord-001397-nrq4ncdf 404 41 2011 2011 CD cord-001397-nrq4ncdf 404 42 ) ) -RRB- cord-001397-nrq4ncdf 404 43 , , , cord-001397-nrq4ncdf 404 44 and and CC cord-001397-nrq4ncdf 404 45 it -PRON- PRP cord-001397-nrq4ncdf 404 46 is be VBZ cord-001397-nrq4ncdf 404 47 known know VBN cord-001397-nrq4ncdf 404 48 that that IN cord-001397-nrq4ncdf 404 49 alligators alligator NNS cord-001397-nrq4ncdf 404 50 and and CC cord-001397-nrq4ncdf 404 51 crocodiles crocodile NNS cord-001397-nrq4ncdf 404 52 can can MD cord-001397-nrq4ncdf 404 53 be be VB cord-001397-nrq4ncdf 404 54 infected infect VBN cord-001397-nrq4ncdf 404 55 with with IN cord-001397-nrq4ncdf 404 56 WNV WNV NNP cord-001397-nrq4ncdf 404 57 . . . cord-001397-nrq4ncdf 405 1 However however RB cord-001397-nrq4ncdf 405 2 , , , cord-001397-nrq4ncdf 405 3 there there EX cord-001397-nrq4ncdf 405 4 are be VBP cord-001397-nrq4ncdf 405 5 no no DT cord-001397-nrq4ncdf 405 6 reports report NNS cord-001397-nrq4ncdf 405 7 suggesting suggest VBG cord-001397-nrq4ncdf 405 8 that that IN cord-001397-nrq4ncdf 405 9 reptiles reptile NNS cord-001397-nrq4ncdf 405 10 host host VBP cord-001397-nrq4ncdf 405 11 persistent persistent JJ cord-001397-nrq4ncdf 405 12 MBFV MBFV NNP cord-001397-nrq4ncdf 405 13 infection infection NN cord-001397-nrq4ncdf 405 14 . . . cord-001397-nrq4ncdf 406 1 In in IN cord-001397-nrq4ncdf 406 2 summary summary NN cord-001397-nrq4ncdf 406 3 , , , cord-001397-nrq4ncdf 406 4 it -PRON- PRP cord-001397-nrq4ncdf 406 5 is be VBZ cord-001397-nrq4ncdf 406 6 apparent apparent JJ cord-001397-nrq4ncdf 406 7 that that IN cord-001397-nrq4ncdf 406 8 various various JJ cord-001397-nrq4ncdf 406 9 animals animal NNS cord-001397-nrq4ncdf 406 10 and and CC cord-001397-nrq4ncdf 406 11 birds bird NNS cord-001397-nrq4ncdf 406 12 can can MD cord-001397-nrq4ncdf 406 13 sponsor sponsor VB cord-001397-nrq4ncdf 406 14 persistent persistent JJ cord-001397-nrq4ncdf 406 15 VBFV vbfv NN cord-001397-nrq4ncdf 406 16 infection infection NN cord-001397-nrq4ncdf 406 17 . . . cord-001397-nrq4ncdf 407 1 Nevertheless nevertheless RB cord-001397-nrq4ncdf 407 2 , , , cord-001397-nrq4ncdf 407 3 the the DT cord-001397-nrq4ncdf 407 4 precise precise JJ cord-001397-nrq4ncdf 407 5 role role NN cord-001397-nrq4ncdf 407 6 that that IN cord-001397-nrq4ncdf 407 7 these these DT cord-001397-nrq4ncdf 407 8 persistent persistent JJ cord-001397-nrq4ncdf 407 9 infections infection NNS cord-001397-nrq4ncdf 407 10 play play VBP cord-001397-nrq4ncdf 407 11 in in IN cord-001397-nrq4ncdf 407 12 larger large JJR cord-001397-nrq4ncdf 407 13 scheme scheme NN cord-001397-nrq4ncdf 407 14 of of IN cord-001397-nrq4ncdf 407 15 viral viral JJ cord-001397-nrq4ncdf 407 16 maintenance maintenance NN cord-001397-nrq4ncdf 407 17 merits merit NNS cord-001397-nrq4ncdf 407 18 additional additional JJ cord-001397-nrq4ncdf 407 19 study study NN cord-001397-nrq4ncdf 407 20 . . . cord-001397-nrq4ncdf 408 1 There there EX cord-001397-nrq4ncdf 408 2 are be VBP cord-001397-nrq4ncdf 408 3 several several JJ cord-001397-nrq4ncdf 408 4 animal animal NN cord-001397-nrq4ncdf 408 5 models model NNS cord-001397-nrq4ncdf 408 6 of of IN cord-001397-nrq4ncdf 408 7 persistent persistent JJ cord-001397-nrq4ncdf 408 8 mosquito mosquito NN cord-001397-nrq4ncdf 408 9 - - HYPH cord-001397-nrq4ncdf 408 10 borne bear VBN cord-001397-nrq4ncdf 408 11 flavivirus flavivirus JJ cord-001397-nrq4ncdf 408 12 infection infection NN cord-001397-nrq4ncdf 408 13 , , , cord-001397-nrq4ncdf 408 14 including include VBG cord-001397-nrq4ncdf 408 15 WNV WNV NNP cord-001397-nrq4ncdf 408 16 and and CC cord-001397-nrq4ncdf 408 17 SLEV SLEV NNP cord-001397-nrq4ncdf 409 1 ( ( -LRB- cord-001397-nrq4ncdf 409 2 Charlier Charlier NNP cord-001397-nrq4ncdf 409 3 et et NNP cord-001397-nrq4ncdf 409 4 al al NNP cord-001397-nrq4ncdf 409 5 . . NNP cord-001397-nrq4ncdf 409 6 , , , cord-001397-nrq4ncdf 409 7 2004 2004 CD cord-001397-nrq4ncdf 409 8 ; ; : cord-001397-nrq4ncdf 409 9 Kimura Kimura NNP cord-001397-nrq4ncdf 409 10 et et FW cord-001397-nrq4ncdf 409 11 al al NNP cord-001397-nrq4ncdf 409 12 . . NNP cord-001397-nrq4ncdf 409 13 , , , cord-001397-nrq4ncdf 409 14 2010 2010 CD cord-001397-nrq4ncdf 409 15 ) ) -RRB- cord-001397-nrq4ncdf 409 16 . . . cord-001397-nrq4ncdf 410 1 As as IN cord-001397-nrq4ncdf 410 2 shown show VBN cord-001397-nrq4ncdf 410 3 in in IN cord-001397-nrq4ncdf 410 4 Table Table NNP cord-001397-nrq4ncdf 410 5 2 2 CD cord-001397-nrq4ncdf 410 6 , , , cord-001397-nrq4ncdf 410 7 mice mouse NNS cord-001397-nrq4ncdf 410 8 and and CC cord-001397-nrq4ncdf 410 9 hamsters hamster NNS cord-001397-nrq4ncdf 410 10 have have VBP cord-001397-nrq4ncdf 410 11 been be VBN cord-001397-nrq4ncdf 410 12 the the DT cord-001397-nrq4ncdf 410 13 main main JJ cord-001397-nrq4ncdf 410 14 study study NN cord-001397-nrq4ncdf 410 15 models model NNS cord-001397-nrq4ncdf 410 16 . . . cord-001397-nrq4ncdf 411 1 In in IN cord-001397-nrq4ncdf 411 2 a a DT cord-001397-nrq4ncdf 411 3 nonhuman nonhuman NN cord-001397-nrq4ncdf 411 4 primate primate NN cord-001397-nrq4ncdf 411 5 study study NN cord-001397-nrq4ncdf 411 6 , , , cord-001397-nrq4ncdf 411 7 WNV WNV NNP cord-001397-nrq4ncdf 411 8 was be VBD cord-001397-nrq4ncdf 411 9 isolated isolate VBN cord-001397-nrq4ncdf 411 10 from from IN cord-001397-nrq4ncdf 411 11 central central JJ cord-001397-nrq4ncdf 411 12 nervous nervous JJ cord-001397-nrq4ncdf 411 13 system system NN cord-001397-nrq4ncdf 411 14 tissues tissue VBZ cord-001397-nrq4ncdf 411 15 more more JJR cord-001397-nrq4ncdf 411 16 than than IN cord-001397-nrq4ncdf 411 17 5 5 CD cord-001397-nrq4ncdf 411 18 months month NNS cord-001397-nrq4ncdf 411 19 post post JJ cord-001397-nrq4ncdf 411 20 - - JJ cord-001397-nrq4ncdf 411 21 intra intra JJ cord-001397-nrq4ncdf 411 22 - - JJ cord-001397-nrq4ncdf 411 23 cerebral cerebral JJ cord-001397-nrq4ncdf 411 24 inoculation inoculation NN cord-001397-nrq4ncdf 411 25 , , , cord-001397-nrq4ncdf 411 26 suggesting suggest VBG cord-001397-nrq4ncdf 411 27 that that IN cord-001397-nrq4ncdf 411 28 these these DT cord-001397-nrq4ncdf 411 29 species specie NNS cord-001397-nrq4ncdf 411 30 might may MD cord-001397-nrq4ncdf 411 31 also also RB cord-001397-nrq4ncdf 411 32 be be VB cord-001397-nrq4ncdf 411 33 relevant relevant JJ cord-001397-nrq4ncdf 411 34 system system NN cord-001397-nrq4ncdf 411 35 . . . cord-001397-nrq4ncdf 412 1 Persistent persistent JJ cord-001397-nrq4ncdf 412 2 WNV WNV NNP cord-001397-nrq4ncdf 412 3 has have VBZ cord-001397-nrq4ncdf 412 4 also also RB cord-001397-nrq4ncdf 412 5 been be VBN cord-001397-nrq4ncdf 412 6 studied study VBN cord-001397-nrq4ncdf 412 7 experimentally experimentally RB cord-001397-nrq4ncdf 412 8 in in IN cord-001397-nrq4ncdf 412 9 the the DT cord-001397-nrq4ncdf 412 10 golden golden JJ cord-001397-nrq4ncdf 412 11 hamster hamster NN cord-001397-nrq4ncdf 412 12 . . . cord-001397-nrq4ncdf 413 1 The the DT cord-001397-nrq4ncdf 413 2 clinical clinical JJ cord-001397-nrq4ncdf 413 3 outcomes outcome NNS cord-001397-nrq4ncdf 413 4 of of IN cord-001397-nrq4ncdf 413 5 WNV WNV NNP cord-001397-nrq4ncdf 413 6 infection infection NN cord-001397-nrq4ncdf 413 7 in in IN cord-001397-nrq4ncdf 413 8 hamsters hamster NNS cord-001397-nrq4ncdf 413 9 vary vary VBP cord-001397-nrq4ncdf 413 10 and and CC cord-001397-nrq4ncdf 413 11 depend depend VBP cord-001397-nrq4ncdf 413 12 on on IN cord-001397-nrq4ncdf 413 13 animal animal NN cord-001397-nrq4ncdf 413 14 age age NN cord-001397-nrq4ncdf 413 15 and and CC cord-001397-nrq4ncdf 413 16 immune immune JJ cord-001397-nrq4ncdf 413 17 competence competence NN cord-001397-nrq4ncdf 413 18 , , , cord-001397-nrq4ncdf 413 19 viral viral JJ cord-001397-nrq4ncdf 413 20 dose dose NN cord-001397-nrq4ncdf 413 21 , , , cord-001397-nrq4ncdf 413 22 and and CC cord-001397-nrq4ncdf 413 23 route route NN cord-001397-nrq4ncdf 413 24 of of IN cord-001397-nrq4ncdf 413 25 infection infection NN cord-001397-nrq4ncdf 413 26 . . . cord-001397-nrq4ncdf 414 1 WNV WNV NNP cord-001397-nrq4ncdf 414 2 infection infection NN cord-001397-nrq4ncdf 414 3 can can MD cord-001397-nrq4ncdf 414 4 lead lead VB cord-001397-nrq4ncdf 414 5 to to IN cord-001397-nrq4ncdf 414 6 asymptomatic asymptomatic JJ cord-001397-nrq4ncdf 414 7 illness illness NN cord-001397-nrq4ncdf 414 8 , , , cord-001397-nrq4ncdf 414 9 encephalitis encephalitis RB cord-001397-nrq4ncdf 414 10 , , , cord-001397-nrq4ncdf 414 11 severe severe JJ cord-001397-nrq4ncdf 414 12 paralysis paralysis NN cord-001397-nrq4ncdf 414 13 , , , cord-001397-nrq4ncdf 414 14 and and CC cord-001397-nrq4ncdf 414 15 acute acute JJ cord-001397-nrq4ncdf 414 16 death death NN cord-001397-nrq4ncdf 414 17 ( ( -LRB- cord-001397-nrq4ncdf 414 18 Xiao Xiao NNP cord-001397-nrq4ncdf 414 19 et et NNP cord-001397-nrq4ncdf 414 20 al al NNP cord-001397-nrq4ncdf 414 21 . . NNP cord-001397-nrq4ncdf 414 22 , , , cord-001397-nrq4ncdf 414 23 2001 2001 CD cord-001397-nrq4ncdf 414 24 ; ; : cord-001397-nrq4ncdf 414 25 Morrey Morrey NNP cord-001397-nrq4ncdf 414 26 et et NNP cord-001397-nrq4ncdf 414 27 al al NNP cord-001397-nrq4ncdf 414 28 . . NNP cord-001397-nrq4ncdf 414 29 , , , cord-001397-nrq4ncdf 414 30 2004 2004 CD cord-001397-nrq4ncdf 414 31 ; ; : cord-001397-nrq4ncdf 414 32 Tesh Tesh NNP cord-001397-nrq4ncdf 414 33 et et NNP cord-001397-nrq4ncdf 414 34 al al NNP cord-001397-nrq4ncdf 414 35 . . NNP cord-001397-nrq4ncdf 414 36 , , , cord-001397-nrq4ncdf 414 37 2005 2005 CD cord-001397-nrq4ncdf 414 38 ) ) -RRB- cord-001397-nrq4ncdf 414 39 . . . cord-001397-nrq4ncdf 415 1 Adult adult JJ cord-001397-nrq4ncdf 415 2 golden golden JJ cord-001397-nrq4ncdf 415 3 hamsters hamster NNS cord-001397-nrq4ncdf 415 4 infected infect VBN cord-001397-nrq4ncdf 415 5 with with IN cord-001397-nrq4ncdf 415 6 WNV WNV NNP cord-001397-nrq4ncdf 415 7 develop develop VB cord-001397-nrq4ncdf 415 8 chronic chronic JJ cord-001397-nrq4ncdf 415 9 infection infection NN cord-001397-nrq4ncdf 415 10 , , , cord-001397-nrq4ncdf 415 11 characterized characterize VBN cord-001397-nrq4ncdf 415 12 by by IN cord-001397-nrq4ncdf 415 13 shedding shed VBG cord-001397-nrq4ncdf 415 14 of of IN cord-001397-nrq4ncdf 415 15 virus virus NN cord-001397-nrq4ncdf 415 16 in in IN cord-001397-nrq4ncdf 415 17 urine urine NN cord-001397-nrq4ncdf 415 18 for for IN cord-001397-nrq4ncdf 415 19 up up IN cord-001397-nrq4ncdf 415 20 to to TO cord-001397-nrq4ncdf 415 21 8 8 CD cord-001397-nrq4ncdf 415 22 months month NNS cord-001397-nrq4ncdf 415 23 ( ( -LRB- cord-001397-nrq4ncdf 415 24 Xiao Xiao NNP cord-001397-nrq4ncdf 415 25 et et NNP cord-001397-nrq4ncdf 415 26 al al NNP cord-001397-nrq4ncdf 415 27 . . . cord-001397-nrq4ncdf 416 1 , , , cord-001397-nrq4ncdf 416 2 2001 2001 CD cord-001397-nrq4ncdf 416 3 ; ; : cord-001397-nrq4ncdf 416 4 Ding Ding NNP cord-001397-nrq4ncdf 416 5 et et FW cord-001397-nrq4ncdf 416 6 al al NNP cord-001397-nrq4ncdf 416 7 . . NNP cord-001397-nrq4ncdf 416 8 , , , cord-001397-nrq4ncdf 416 9 2005 2005 CD cord-001397-nrq4ncdf 417 1 ; ; : cord-001397-nrq4ncdf 417 2 Tonry Tonry NNP cord-001397-nrq4ncdf 417 3 et et FW cord-001397-nrq4ncdf 417 4 al al NNP cord-001397-nrq4ncdf 417 5 . . NNP cord-001397-nrq4ncdf 417 6 , , , cord-001397-nrq4ncdf 417 7 2005 2005 CD cord-001397-nrq4ncdf 417 8 ) ) -RRB- cord-001397-nrq4ncdf 417 9 . . . cord-001397-nrq4ncdf 418 1 The the DT cord-001397-nrq4ncdf 418 2 chronically chronically RB cord-001397-nrq4ncdf 418 3 infected infect VBN cord-001397-nrq4ncdf 418 4 animals animal NNS cord-001397-nrq4ncdf 418 5 exhibit exhibit VBP cord-001397-nrq4ncdf 418 6 antigens antigen NNS cord-001397-nrq4ncdf 418 7 in in IN cord-001397-nrq4ncdf 418 8 tubular tubular JJ cord-001397-nrq4ncdf 418 9 epithelial epithelial JJ cord-001397-nrq4ncdf 418 10 cells cell NNS cord-001397-nrq4ncdf 418 11 , , , cord-001397-nrq4ncdf 418 12 interstitial interstitial JJ cord-001397-nrq4ncdf 418 13 cells cell NNS cord-001397-nrq4ncdf 418 14 , , , cord-001397-nrq4ncdf 418 15 and and CC cord-001397-nrq4ncdf 418 16 macrophages macrophage NNS cord-001397-nrq4ncdf 418 17 of of IN cord-001397-nrq4ncdf 418 18 distal distal JJ cord-001397-nrq4ncdf 418 19 renal renal JJ cord-001397-nrq4ncdf 418 20 tubules tubule NNS cord-001397-nrq4ncdf 418 21 . . . cord-001397-nrq4ncdf 419 1 Interestingly interestingly RB cord-001397-nrq4ncdf 419 2 , , , cord-001397-nrq4ncdf 419 3 na€ na€ NNP cord-001397-nrq4ncdf 419 4 ıve ıve JJ cord-001397-nrq4ncdf 419 5 hamsters hamster NNS cord-001397-nrq4ncdf 419 6 inoculated inoculate VBD cord-001397-nrq4ncdf 419 7 intraperitoneally intraperitoneally RB cord-001397-nrq4ncdf 419 8 with with IN cord-001397-nrq4ncdf 419 9 WNV WNV NNP cord-001397-nrq4ncdf 419 10 - - HYPH cord-001397-nrq4ncdf 419 11 containing contain VBG cord-001397-nrq4ncdf 419 12 urine urine NN cord-001397-nrq4ncdf 419 13 from from IN cord-001397-nrq4ncdf 419 14 persistently persistently RB cord-001397-nrq4ncdf 419 15 infected infect VBN cord-001397-nrq4ncdf 419 16 hamster hamster NN cord-001397-nrq4ncdf 419 17 do do VBP cord-001397-nrq4ncdf 419 18 not not RB cord-001397-nrq4ncdf 419 19 develop develop VB cord-001397-nrq4ncdf 419 20 clinical clinical JJ cord-001397-nrq4ncdf 419 21 disease disease NN cord-001397-nrq4ncdf 419 22 , , , cord-001397-nrq4ncdf 419 23 but but CC cord-001397-nrq4ncdf 419 24 the the DT cord-001397-nrq4ncdf 419 25 hamsters hamster NNS cord-001397-nrq4ncdf 419 26 become become VBP cord-001397-nrq4ncdf 419 27 viremic viremic JJ cord-001397-nrq4ncdf 419 28 and and CC cord-001397-nrq4ncdf 419 29 develop develop VB cord-001397-nrq4ncdf 419 30 antibody antibody NN cord-001397-nrq4ncdf 419 31 responses response NNS cord-001397-nrq4ncdf 419 32 ( ( -LRB- cord-001397-nrq4ncdf 419 33 Ding Ding NNP cord-001397-nrq4ncdf 419 34 et et FW cord-001397-nrq4ncdf 419 35 al al NNP cord-001397-nrq4ncdf 419 36 . . NNP cord-001397-nrq4ncdf 419 37 , , , cord-001397-nrq4ncdf 419 38 2005 2005 CD cord-001397-nrq4ncdf 419 39 ) ) -RRB- cord-001397-nrq4ncdf 419 40 . . . cord-001397-nrq4ncdf 420 1 This this DT cord-001397-nrq4ncdf 420 2 suggests suggest VBZ cord-001397-nrq4ncdf 420 3 possible possible JJ cord-001397-nrq4ncdf 420 4 viral viral JJ cord-001397-nrq4ncdf 420 5 genetic genetic JJ cord-001397-nrq4ncdf 420 6 changes change NNS cord-001397-nrq4ncdf 420 7 , , , cord-001397-nrq4ncdf 420 8 which which WDT cord-001397-nrq4ncdf 420 9 may may MD cord-001397-nrq4ncdf 420 10 facilitate facilitate VB cord-001397-nrq4ncdf 420 11 persistent persistent JJ cord-001397-nrq4ncdf 420 12 infection infection NN cord-001397-nrq4ncdf 420 13 , , , cord-001397-nrq4ncdf 420 14 although although IN cord-001397-nrq4ncdf 420 15 other other JJ cord-001397-nrq4ncdf 420 16 explanations explanation NNS cord-001397-nrq4ncdf 420 17 can can MD cord-001397-nrq4ncdf 420 18 not not RB cord-001397-nrq4ncdf 420 19 be be VB cord-001397-nrq4ncdf 420 20 totally totally RB cord-001397-nrq4ncdf 420 21 excluded exclude VBN cord-001397-nrq4ncdf 420 22 . . . cord-001397-nrq4ncdf 421 1 Hamsters hamster NNS cord-001397-nrq4ncdf 421 2 have have VBP cord-001397-nrq4ncdf 421 3 also also RB cord-001397-nrq4ncdf 421 4 been be VBN cord-001397-nrq4ncdf 421 5 used use VBN cord-001397-nrq4ncdf 421 6 as as IN cord-001397-nrq4ncdf 421 7 experimental experimental JJ cord-001397-nrq4ncdf 421 8 models model NNS cord-001397-nrq4ncdf 421 9 to to TO cord-001397-nrq4ncdf 421 10 study study VB cord-001397-nrq4ncdf 421 11 the the DT cord-001397-nrq4ncdf 421 12 persistence persistence NN cord-001397-nrq4ncdf 421 13 of of IN cord-001397-nrq4ncdf 421 14 SLEV SLEV NNP cord-001397-nrq4ncdf 421 15 and and CC cord-001397-nrq4ncdf 421 16 are be VBP cord-001397-nrq4ncdf 421 17 among among IN cord-001397-nrq4ncdf 421 18 the the DT cord-001397-nrq4ncdf 421 19 natural natural JJ cord-001397-nrq4ncdf 421 20 vertebrate vertebrate JJ cord-001397-nrq4ncdf 421 21 hosts host NNS cord-001397-nrq4ncdf 421 22 of of IN cord-001397-nrq4ncdf 421 23 the the DT cord-001397-nrq4ncdf 421 24 Banzi Banzi NNP cord-001397-nrq4ncdf 421 25 flavivirus flavivirus NNP cord-001397-nrq4ncdf 421 26 , , , cord-001397-nrq4ncdf 421 27 a a DT cord-001397-nrq4ncdf 421 28 member member NN cord-001397-nrq4ncdf 421 29 of of IN cord-001397-nrq4ncdf 421 30 the the DT cord-001397-nrq4ncdf 421 31 YFV YFV NNP cord-001397-nrq4ncdf 421 32 group group NN cord-001397-nrq4ncdf 421 33 of of IN cord-001397-nrq4ncdf 421 34 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 422 1 ( ( -LRB- cord-001397-nrq4ncdf 422 2 Grard Grard NNP cord-001397-nrq4ncdf 422 3 et et NNP cord-001397-nrq4ncdf 422 4 al al NNP cord-001397-nrq4ncdf 422 5 . . NNP cord-001397-nrq4ncdf 422 6 , , , cord-001397-nrq4ncdf 422 7 2010 2010 CD cord-001397-nrq4ncdf 422 8 ) ) -RRB- cord-001397-nrq4ncdf 422 9 . . . cord-001397-nrq4ncdf 423 1 Golden golden JJ cord-001397-nrq4ncdf 423 2 hamsters hamster NNS cord-001397-nrq4ncdf 423 3 infected infect VBN cord-001397-nrq4ncdf 423 4 with with IN cord-001397-nrq4ncdf 423 5 SLEV SLEV NNP cord-001397-nrq4ncdf 423 6 did do VBD cord-001397-nrq4ncdf 423 7 not not RB cord-001397-nrq4ncdf 423 8 develop develop VB cord-001397-nrq4ncdf 423 9 clinical clinical JJ cord-001397-nrq4ncdf 423 10 signs sign NNS cord-001397-nrq4ncdf 423 11 of of IN cord-001397-nrq4ncdf 423 12 illness illness NN cord-001397-nrq4ncdf 423 13 , , , cord-001397-nrq4ncdf 423 14 but but CC cord-001397-nrq4ncdf 423 15 they -PRON- PRP cord-001397-nrq4ncdf 423 16 developed develop VBD cord-001397-nrq4ncdf 423 17 viruria viruria NN cord-001397-nrq4ncdf 423 18 and and CC cord-001397-nrq4ncdf 423 19 antibodies antibody NNS cord-001397-nrq4ncdf 423 20 against against IN cord-001397-nrq4ncdf 423 21 SLEV SLEV NNP cord-001397-nrq4ncdf 423 22 at at IN cord-001397-nrq4ncdf 423 23 28 28 CD cord-001397-nrq4ncdf 423 24 days day NNS cord-001397-nrq4ncdf 423 25 postinfection postinfection NN cord-001397-nrq4ncdf 424 1 ( ( -LRB- cord-001397-nrq4ncdf 424 2 Siirin Siirin NNP cord-001397-nrq4ncdf 424 3 et et NNP cord-001397-nrq4ncdf 424 4 al al NNP cord-001397-nrq4ncdf 424 5 . . NNP cord-001397-nrq4ncdf 424 6 , , , cord-001397-nrq4ncdf 424 7 2007 2007 CD cord-001397-nrq4ncdf 424 8 ) ) -RRB- cord-001397-nrq4ncdf 424 9 . . . cord-001397-nrq4ncdf 425 1 ( ( -LRB- cord-001397-nrq4ncdf 425 2 Appler Appler NNP cord-001397-nrq4ncdf 425 3 et et NNP cord-001397-nrq4ncdf 425 4 al al NNP cord-001397-nrq4ncdf 425 5 . . NNP cord-001397-nrq4ncdf 425 6 , , , cord-001397-nrq4ncdf 425 7 2010 2010 CD cord-001397-nrq4ncdf 425 8 ; ; : cord-001397-nrq4ncdf 425 9 Pierson Pierson NNP cord-001397-nrq4ncdf 425 10 & & CC cord-001397-nrq4ncdf 425 11 Diamond Diamond NNP cord-001397-nrq4ncdf 425 12 , , , cord-001397-nrq4ncdf 425 13 2012 2012 CD cord-001397-nrq4ncdf 425 14 ) ) -RRB- cord-001397-nrq4ncdf 425 15 : : : cord-001397-nrq4ncdf 425 16 WNV WNV NNP cord-001397-nrq4ncdf 425 17 RNA RNA NNP cord-001397-nrq4ncdf 425 18 persisted persist VBD cord-001397-nrq4ncdf 425 19 in in IN cord-001397-nrq4ncdf 425 20 a a DT cord-001397-nrq4ncdf 425 21 pantropic pantropic JJ cord-001397-nrq4ncdf 425 22 manner manner NN cord-001397-nrq4ncdf 425 23 in in IN cord-001397-nrq4ncdf 425 24 12 12 CD cord-001397-nrq4ncdf 425 25 % % NN cord-001397-nrq4ncdf 425 26 of of IN cord-001397-nrq4ncdf 425 27 infected infected JJ cord-001397-nrq4ncdf 425 28 mice mouse NNS cord-001397-nrq4ncdf 425 29 for for IN cord-001397-nrq4ncdf 425 30 up up IN cord-001397-nrq4ncdf 425 31 to to TO cord-001397-nrq4ncdf 425 32 6 6 CD cord-001397-nrq4ncdf 425 33 months month NNS cord-001397-nrq4ncdf 425 34 . . . cord-001397-nrq4ncdf 426 1 Infectious infectious JJ cord-001397-nrq4ncdf 426 2 virus virus NN cord-001397-nrq4ncdf 426 3 could could MD cord-001397-nrq4ncdf 426 4 be be VB cord-001397-nrq4ncdf 426 5 isolated isolate VBN cord-001397-nrq4ncdf 426 6 in in IN cord-001397-nrq4ncdf 426 7 12 12 CD cord-001397-nrq4ncdf 426 8 % % NN cord-001397-nrq4ncdf 426 9 of of IN cord-001397-nrq4ncdf 426 10 mice mouse NNS cord-001397-nrq4ncdf 426 11 for for IN cord-001397-nrq4ncdf 426 12 up up IN cord-001397-nrq4ncdf 426 13 to to TO cord-001397-nrq4ncdf 426 14 4 4 CD cord-001397-nrq4ncdf 426 15 months month NNS cord-001397-nrq4ncdf 426 16 . . . cord-001397-nrq4ncdf 427 1 C3H c3h JJ cord-001397-nrq4ncdf 427 2 mice mice NN cord-001397-nrq4ncdf 427 3 survival survival NN cord-001397-nrq4ncdf 427 4 rate rate NN cord-001397-nrq4ncdf 427 5 was be VBD cord-001397-nrq4ncdf 427 6 lower low JJR cord-001397-nrq4ncdf 427 7 and and CC cord-001397-nrq4ncdf 427 8 22 22 CD cord-001397-nrq4ncdf 427 9 % % NN cord-001397-nrq4ncdf 427 10 when when WRB cord-001397-nrq4ncdf 427 11 compared compare VBN cord-001397-nrq4ncdf 427 12 to to IN cord-001397-nrq4ncdf 427 13 the the DT cord-001397-nrq4ncdf 427 14 survival survival NN cord-001397-nrq4ncdf 427 15 rate rate NN cord-001397-nrq4ncdf 427 16 of of IN cord-001397-nrq4ncdf 427 17 B6 b6 NN cord-001397-nrq4ncdf 427 18 mice mouse NNS cord-001397-nrq4ncdf 427 19 , , , cord-001397-nrq4ncdf 427 20 which which WDT cord-001397-nrq4ncdf 427 21 was be VBD cord-001397-nrq4ncdf 427 22 78 78 CD cord-001397-nrq4ncdf 427 23 % % NN cord-001397-nrq4ncdf 427 24 Macaque Macaque NNP cord-001397-nrq4ncdf 427 25 rhesus rhesu NNS cord-001397-nrq4ncdf 427 26 ( ( -LRB- cord-001397-nrq4ncdf 427 27 Pogodina Pogodina NNP cord-001397-nrq4ncdf 427 28 et et NNP cord-001397-nrq4ncdf 427 29 al al NNP cord-001397-nrq4ncdf 427 30 . . NNP cord-001397-nrq4ncdf 427 31 , , , cord-001397-nrq4ncdf 427 32 1981 1981 CD cord-001397-nrq4ncdf 427 33 ) ) -RRB- cord-001397-nrq4ncdf 427 34 : : : cord-001397-nrq4ncdf 428 1 Virus virus NN cord-001397-nrq4ncdf 428 2 persisted persist VBD cord-001397-nrq4ncdf 428 3 in in IN cord-001397-nrq4ncdf 428 4 asymptomatic asymptomatic JJ cord-001397-nrq4ncdf 428 5 animals animal NNS cord-001397-nrq4ncdf 428 6 for for IN cord-001397-nrq4ncdf 428 7 5½ 5½ CD cord-001397-nrq4ncdf 428 8 months month NNS cord-001397-nrq4ncdf 428 9 and and CC cord-001397-nrq4ncdf 428 10 could could MD cord-001397-nrq4ncdf 428 11 be be VB cord-001397-nrq4ncdf 428 12 isolated isolate VBN cord-001397-nrq4ncdf 428 13 from from IN cord-001397-nrq4ncdf 428 14 cerebellum cerebellum NN cord-001397-nrq4ncdf 428 15 , , , cord-001397-nrq4ncdf 428 16 cerebral cerebral JJ cord-001397-nrq4ncdf 428 17 subcortical subcortical JJ cord-001397-nrq4ncdf 428 18 ganglia ganglion NNS cord-001397-nrq4ncdf 428 19 , , , cord-001397-nrq4ncdf 428 20 lymph lymph NN cord-001397-nrq4ncdf 428 21 nodes node NNS cord-001397-nrq4ncdf 428 22 , , , cord-001397-nrq4ncdf 428 23 and and CC cord-001397-nrq4ncdf 428 24 kidneys kidney NNS cord-001397-nrq4ncdf 428 25 Golden golden JJ cord-001397-nrq4ncdf 428 26 hamster hamster NN cord-001397-nrq4ncdf 428 27 ( ( -LRB- cord-001397-nrq4ncdf 428 28 Mesocricetus Mesocricetus NNP cord-001397-nrq4ncdf 428 29 auratus auratus NN cord-001397-nrq4ncdf 428 30 ; ; : cord-001397-nrq4ncdf 428 31 Tesh Tesh NNP cord-001397-nrq4ncdf 428 32 et et FW cord-001397-nrq4ncdf 428 33 al al NNP cord-001397-nrq4ncdf 428 34 . . NNP cord-001397-nrq4ncdf 428 35 , , , cord-001397-nrq4ncdf 428 36 2005 2005 CD cord-001397-nrq4ncdf 428 37 ; ; : cord-001397-nrq4ncdf 429 1 Tonry Tonry NNP cord-001397-nrq4ncdf 429 2 et et FW cord-001397-nrq4ncdf 429 3 al al NNP cord-001397-nrq4ncdf 429 4 . . NNP cord-001397-nrq4ncdf 429 5 , , , cord-001397-nrq4ncdf 429 6 2005 2005 CD cord-001397-nrq4ncdf 429 7 ) ) -RRB- cord-001397-nrq4ncdf 430 1 : : : cord-001397-nrq4ncdf 430 2 Chronic chronic JJ cord-001397-nrq4ncdf 430 3 renal renal JJ cord-001397-nrq4ncdf 430 4 infection infection NN cord-001397-nrq4ncdf 430 5 with with IN cord-001397-nrq4ncdf 430 6 persistent persistent JJ cord-001397-nrq4ncdf 430 7 shedding shedding NN cord-001397-nrq4ncdf 430 8 of of IN cord-001397-nrq4ncdf 430 9 virus virus NN cord-001397-nrq4ncdf 430 10 for for IN cord-001397-nrq4ncdf 430 11 up up IN cord-001397-nrq4ncdf 430 12 to to TO cord-001397-nrq4ncdf 430 13 8 8 CD cord-001397-nrq4ncdf 430 14 months month NNS cord-001397-nrq4ncdf 430 15 . . . cord-001397-nrq4ncdf 431 1 Virus virus NN cord-001397-nrq4ncdf 431 2 could could MD cord-001397-nrq4ncdf 431 3 be be VB cord-001397-nrq4ncdf 431 4 recovered recover VBN cord-001397-nrq4ncdf 431 5 by by IN cord-001397-nrq4ncdf 431 6 culture culture NN cord-001397-nrq4ncdf 431 7 , , , cord-001397-nrq4ncdf 431 8 and and CC cord-001397-nrq4ncdf 431 9 genotypic genotypic JJ cord-001397-nrq4ncdf 431 10 and and CC cord-001397-nrq4ncdf 431 11 phenotypic phenotypic JJ cord-001397-nrq4ncdf 431 12 changes change NNS cord-001397-nrq4ncdf 431 13 were be VBD cord-001397-nrq4ncdf 431 14 identified identify VBN cord-001397-nrq4ncdf 431 15 House House NNP cord-001397-nrq4ncdf 431 16 sparrow sparrow NN cord-001397-nrq4ncdf 431 17 ( ( -LRB- cord-001397-nrq4ncdf 431 18 Passer Passer NNP cord-001397-nrq4ncdf 431 19 domesticus domesticus NN cord-001397-nrq4ncdf 431 20 ; ; : cord-001397-nrq4ncdf 431 21 Nemeth Nemeth NNP cord-001397-nrq4ncdf 431 22 et et NNP cord-001397-nrq4ncdf 431 23 al al NNP cord-001397-nrq4ncdf 431 24 . . NNP cord-001397-nrq4ncdf 431 25 , , , cord-001397-nrq4ncdf 431 26 2009 2009 CD cord-001397-nrq4ncdf 431 27 ) ) -RRB- cord-001397-nrq4ncdf 431 28 : : : cord-001397-nrq4ncdf 431 29 infectious infectious JJ cord-001397-nrq4ncdf 431 30 virus virus NN cord-001397-nrq4ncdf 431 31 persisted persist VBD cord-001397-nrq4ncdf 431 32 in in IN cord-001397-nrq4ncdf 431 33 tissues tissue NNS cord-001397-nrq4ncdf 431 34 for for IN cord-001397-nrq4ncdf 431 35 up up IN cord-001397-nrq4ncdf 431 36 to to TO cord-001397-nrq4ncdf 431 37 43 43 CD cord-001397-nrq4ncdf 431 38 days day NNS cord-001397-nrq4ncdf 431 39 , , , cord-001397-nrq4ncdf 431 40 but but CC cord-001397-nrq4ncdf 431 41 was be VBD cord-001397-nrq4ncdf 431 42 not not RB cord-001397-nrq4ncdf 431 43 detectable detectable JJ cord-001397-nrq4ncdf 431 44 in in IN cord-001397-nrq4ncdf 431 45 sera sera NNP cord-001397-nrq4ncdf 431 46 after after IN cord-001397-nrq4ncdf 431 47 6 6 CD cord-001397-nrq4ncdf 431 48 days day NNS cord-001397-nrq4ncdf 431 49 . . . cord-001397-nrq4ncdf 432 1 WNV WNV NNP cord-001397-nrq4ncdf 432 2 RNA RNA NNP cord-001397-nrq4ncdf 432 3 persisted persist VBD cord-001397-nrq4ncdf 432 4 in in IN cord-001397-nrq4ncdf 432 5 tissues tissue NNS cord-001397-nrq4ncdf 432 6 for for IN cord-001397-nrq4ncdf 432 7 up up IN cord-001397-nrq4ncdf 432 8 to to TO cord-001397-nrq4ncdf 432 9 65 65 CD cord-001397-nrq4ncdf 432 10 days day NNS cord-001397-nrq4ncdf 432 11 SLEV SLEV NNP cord-001397-nrq4ncdf 432 12 Golden golden JJ cord-001397-nrq4ncdf 432 13 hamster hamster NN cord-001397-nrq4ncdf 432 14 ( ( -LRB- cord-001397-nrq4ncdf 432 15 Siirin Siirin NNP cord-001397-nrq4ncdf 432 16 et et NNP cord-001397-nrq4ncdf 432 17 al al NNP cord-001397-nrq4ncdf 432 18 . . NNP cord-001397-nrq4ncdf 432 19 , , , cord-001397-nrq4ncdf 432 20 2007 2007 CD cord-001397-nrq4ncdf 432 21 ) ) -RRB- cord-001397-nrq4ncdf 432 22 : : : cord-001397-nrq4ncdf 432 23 Infected infected JJ cord-001397-nrq4ncdf 432 24 animals animal NNS cord-001397-nrq4ncdf 432 25 remained remain VBD cord-001397-nrq4ncdf 432 26 asymptomatic asymptomatic JJ cord-001397-nrq4ncdf 432 27 , , , cord-001397-nrq4ncdf 432 28 but but CC cord-001397-nrq4ncdf 432 29 virus virus NN cord-001397-nrq4ncdf 432 30 could could MD cord-001397-nrq4ncdf 432 31 be be VB cord-001397-nrq4ncdf 432 32 cocultivated cocultivate VBN cord-001397-nrq4ncdf 432 33 in in IN cord-001397-nrq4ncdf 432 34 various various JJ cord-001397-nrq4ncdf 432 35 organs organ NNS cord-001397-nrq4ncdf 432 36 for for IN cord-001397-nrq4ncdf 432 37 up up IN cord-001397-nrq4ncdf 432 38 to to TO cord-001397-nrq4ncdf 432 39 185 185 CD cord-001397-nrq4ncdf 432 40 days day NNS cord-001397-nrq4ncdf 433 1 JEV JEV NNP cord-001397-nrq4ncdf 433 2 Swiss swiss JJ cord-001397-nrq4ncdf 433 3 albino albino NN cord-001397-nrq4ncdf 433 4 mice mouse NNS cord-001397-nrq4ncdf 433 5 ( ( -LRB- cord-001397-nrq4ncdf 433 6 Mathur Mathur NNP cord-001397-nrq4ncdf 433 7 et et NNP cord-001397-nrq4ncdf 433 8 al al NNP cord-001397-nrq4ncdf 433 9 . . NNP cord-001397-nrq4ncdf 433 10 , , , cord-001397-nrq4ncdf 433 11 1986a 1986a CD cord-001397-nrq4ncdf 433 12 , , , cord-001397-nrq4ncdf 433 13 b b LS cord-001397-nrq4ncdf 433 14 ) ) -RRB- cord-001397-nrq4ncdf 433 15 : : : cord-001397-nrq4ncdf 434 1 Persistence persistence NN cord-001397-nrq4ncdf 434 2 was be VBD cord-001397-nrq4ncdf 434 3 demonstrated demonstrate VBN cord-001397-nrq4ncdf 434 4 by by IN cord-001397-nrq4ncdf 434 5 reactivation reactivation NN cord-001397-nrq4ncdf 434 6 in in IN cord-001397-nrq4ncdf 434 7 41 41 CD cord-001397-nrq4ncdf 434 8 % % NN cord-001397-nrq4ncdf 434 9 of of IN cord-001397-nrq4ncdf 434 10 congenitally congenitally RB cord-001397-nrq4ncdf 434 11 infected infected JJ cord-001397-nrq4ncdf 434 12 pups pup NNS cord-001397-nrq4ncdf 434 13 . . . cord-001397-nrq4ncdf 435 1 In in IN cord-001397-nrq4ncdf 435 2 adult adult NN cord-001397-nrq4ncdf 435 3 mice mouse NNS cord-001397-nrq4ncdf 435 4 , , , cord-001397-nrq4ncdf 435 5 viral viral JJ cord-001397-nrq4ncdf 435 6 persistence persistence NN cord-001397-nrq4ncdf 435 7 was be VBD cord-001397-nrq4ncdf 435 8 shown show VBN cord-001397-nrq4ncdf 435 9 to to TO cord-001397-nrq4ncdf 435 10 last last VB cord-001397-nrq4ncdf 435 11 longer long RBR cord-001397-nrq4ncdf 435 12 ( ( -LRB- cord-001397-nrq4ncdf 435 13 16 16 CD cord-001397-nrq4ncdf 435 14 weeks week NNS cord-001397-nrq4ncdf 435 15 ) ) -RRB- cord-001397-nrq4ncdf 435 16 in in IN cord-001397-nrq4ncdf 435 17 pregnant pregnant JJ cord-001397-nrq4ncdf 435 18 mice mouse NNS cord-001397-nrq4ncdf 435 19 compared compare VBN cord-001397-nrq4ncdf 435 20 with with IN cord-001397-nrq4ncdf 435 21 4 4 CD cord-001397-nrq4ncdf 435 22 weeks week NNS cord-001397-nrq4ncdf 435 23 in in IN cord-001397-nrq4ncdf 435 24 nonpregnant nonpregnant JJ cord-001397-nrq4ncdf 435 25 mice mouse NNS cord-001397-nrq4ncdf 436 1 Tick tick VB cord-001397-nrq4ncdf 436 2 TBEV TBEV NNP cord-001397-nrq4ncdf 436 3 Macaque Macaque NNP cord-001397-nrq4ncdf 436 4 rhesus rhesu NNS cord-001397-nrq4ncdf 436 5 ( ( -LRB- cord-001397-nrq4ncdf 436 6 Pogodina Pogodina NNP cord-001397-nrq4ncdf 436 7 , , , cord-001397-nrq4ncdf 436 8 1983 1983 CD cord-001397-nrq4ncdf 436 9 ; ; . cord-001397-nrq4ncdf 437 1 Pogodina Pogodina NNP cord-001397-nrq4ncdf 437 2 et et NNP cord-001397-nrq4ncdf 437 3 al al NNP cord-001397-nrq4ncdf 437 4 . . . cord-001397-nrq4ncdf 438 1 , , , cord-001397-nrq4ncdf 438 2 1984 1984 CD cord-001397-nrq4ncdf 439 1 Pogodina Pogodina NNP cord-001397-nrq4ncdf 439 2 et et NNP cord-001397-nrq4ncdf 439 3 al al NNP cord-001397-nrq4ncdf 439 4 . . NNP cord-001397-nrq4ncdf 439 5 , , , cord-001397-nrq4ncdf 439 6 , , , cord-001397-nrq4ncdf 439 7 1981 1981 CD cord-001397-nrq4ncdf 440 1 : : : cord-001397-nrq4ncdf 440 2 Monkeys monkey NNS cord-001397-nrq4ncdf 440 3 recovered recover VBD cord-001397-nrq4ncdf 440 4 from from IN cord-001397-nrq4ncdf 440 5 encephalitis encephalitis NN cord-001397-nrq4ncdf 440 6 and and CC cord-001397-nrq4ncdf 440 7 virus virus NN cord-001397-nrq4ncdf 440 8 persisted persist VBD cord-001397-nrq4ncdf 440 9 for for IN cord-001397-nrq4ncdf 440 10 at at RB cord-001397-nrq4ncdf 440 11 least least RBS cord-001397-nrq4ncdf 440 12 738 738 CD cord-001397-nrq4ncdf 440 13 days day NNS cord-001397-nrq4ncdf 440 14 . . . cord-001397-nrq4ncdf 441 1 In in IN cord-001397-nrq4ncdf 441 2 asymptomatic asymptomatic JJ cord-001397-nrq4ncdf 441 3 animals animal NNS cord-001397-nrq4ncdf 441 4 , , , cord-001397-nrq4ncdf 441 5 virus virus NN cord-001397-nrq4ncdf 441 6 persisted persist VBD cord-001397-nrq4ncdf 441 7 for for IN cord-001397-nrq4ncdf 441 8 302 302 CD cord-001397-nrq4ncdf 441 9 days day NNS cord-001397-nrq4ncdf 441 10 LIV LIV NNP cord-001397-nrq4ncdf 441 11 * * NFP cord-001397-nrq4ncdf 441 12 Immunosuppressed immunosuppresse VBN cord-001397-nrq4ncdf 441 13 guinea guinea NN cord-001397-nrq4ncdf 441 14 pigs pig NNS cord-001397-nrq4ncdf 441 15 ( ( -LRB- cord-001397-nrq4ncdf 441 16 Zlotnik Zlotnik NNP cord-001397-nrq4ncdf 441 17 et et NNP cord-001397-nrq4ncdf 441 18 al al NNP cord-001397-nrq4ncdf 441 19 . . NNP cord-001397-nrq4ncdf 441 20 , , , cord-001397-nrq4ncdf 441 21 1971 1971 CD cord-001397-nrq4ncdf 441 22 ) ) -RRB- cord-001397-nrq4ncdf 442 1 : : : cord-001397-nrq4ncdf 442 2 LIV LIV NNP cord-001397-nrq4ncdf 442 3 was be VBD cord-001397-nrq4ncdf 442 4 lethal lethal JJ cord-001397-nrq4ncdf 442 5 in in IN cord-001397-nrq4ncdf 442 6 young young JJ cord-001397-nrq4ncdf 442 7 animals animal NNS cord-001397-nrq4ncdf 442 8 , , , cord-001397-nrq4ncdf 442 9 but but CC cord-001397-nrq4ncdf 442 10 older old JJR cord-001397-nrq4ncdf 442 11 animals animal NNS cord-001397-nrq4ncdf 442 12 acquire acquire VBP cord-001397-nrq4ncdf 442 13 a a DT cord-001397-nrq4ncdf 442 14 nonapparent nonapparent NN cord-001397-nrq4ncdf 442 15 infection infection NN cord-001397-nrq4ncdf 442 16 with with IN cord-001397-nrq4ncdf 442 17 viral viral JJ cord-001397-nrq4ncdf 442 18 replication replication NN cord-001397-nrq4ncdf 442 19 in in IN cord-001397-nrq4ncdf 442 20 the the DT cord-001397-nrq4ncdf 442 21 brain brain NN cord-001397-nrq4ncdf 442 22 and and CC cord-001397-nrq4ncdf 442 23 spleen spleen NNS cord-001397-nrq4ncdf 442 24 POWV POWV NNP cord-001397-nrq4ncdf 442 25 Deer Deer NNP cord-001397-nrq4ncdf 442 26 mouse mouse NN cord-001397-nrq4ncdf 442 27 ( ( -LRB- cord-001397-nrq4ncdf 442 28 Peromyscus Peromyscus NNP cord-001397-nrq4ncdf 442 29 leucopus leucopus NN cord-001397-nrq4ncdf 442 30 ; ; . cord-001397-nrq4ncdf 443 1 Telford Telford NNP cord-001397-nrq4ncdf 443 2 et et NNP cord-001397-nrq4ncdf 443 3 al al NNP cord-001397-nrq4ncdf 443 4 . . NNP cord-001397-nrq4ncdf 443 5 , , , cord-001397-nrq4ncdf 443 6 1997 1997 CD cord-001397-nrq4ncdf 443 7 ) ) -RRB- cord-001397-nrq4ncdf 443 8 : : : cord-001397-nrq4ncdf 443 9 not not RB cord-001397-nrq4ncdf 443 10 a a DT cord-001397-nrq4ncdf 443 11 well well RB cord-001397-nrq4ncdf 443 12 - - HYPH cord-001397-nrq4ncdf 443 13 characterized characterize VBN cord-001397-nrq4ncdf 443 14 model model NN cord-001397-nrq4ncdf 443 15 , , , cord-001397-nrq4ncdf 443 16 but but CC cord-001397-nrq4ncdf 443 17 adult adult NN cord-001397-nrq4ncdf 443 18 mice mouse NNS cord-001397-nrq4ncdf 443 19 appear appear VBP cord-001397-nrq4ncdf 443 20 to to TO cord-001397-nrq4ncdf 443 21 survive survive VB cord-001397-nrq4ncdf 443 22 infection infection NN cord-001397-nrq4ncdf 444 1 * * NFP cord-001397-nrq4ncdf 444 2 Louping loupe VBG cord-001397-nrq4ncdf 444 3 ill ill JJ cord-001397-nrq4ncdf 444 4 virus virus NN cord-001397-nrq4ncdf 444 5 infects infect VBZ cord-001397-nrq4ncdf 444 6 sheep sheep NNS cord-001397-nrq4ncdf 444 7 . . . cord-001397-nrq4ncdf 445 1 Hamsters hamster NNS cord-001397-nrq4ncdf 445 2 that that WDT cord-001397-nrq4ncdf 445 3 become become VBP cord-001397-nrq4ncdf 445 4 persistently persistently RB cord-001397-nrq4ncdf 445 5 infected infect VBN cord-001397-nrq4ncdf 445 6 with with IN cord-001397-nrq4ncdf 445 7 SLEV SLEV NNP cord-001397-nrq4ncdf 445 8 shed shed VBD cord-001397-nrq4ncdf 445 9 virus virus NN cord-001397-nrq4ncdf 445 10 in in IN cord-001397-nrq4ncdf 445 11 their -PRON- PRP$ cord-001397-nrq4ncdf 445 12 urine urine NN cord-001397-nrq4ncdf 445 13 for for IN cord-001397-nrq4ncdf 445 14 up up IN cord-001397-nrq4ncdf 445 15 to to TO cord-001397-nrq4ncdf 445 16 185 185 CD cord-001397-nrq4ncdf 445 17 days day NNS cord-001397-nrq4ncdf 445 18 postinfection postinfection NN cord-001397-nrq4ncdf 445 19 . . . cord-001397-nrq4ncdf 446 1 The the DT cord-001397-nrq4ncdf 446 2 shedding shedding NN cord-001397-nrq4ncdf 446 3 of of IN cord-001397-nrq4ncdf 446 4 virus virus NN cord-001397-nrq4ncdf 446 5 in in IN cord-001397-nrq4ncdf 446 6 the the DT cord-001397-nrq4ncdf 446 7 urine urine NN cord-001397-nrq4ncdf 446 8 of of IN cord-001397-nrq4ncdf 446 9 infected infect VBN cord-001397-nrq4ncdf 446 10 hamsters hamster NNS cord-001397-nrq4ncdf 446 11 also also RB cord-001397-nrq4ncdf 446 12 suggests suggest VBZ cord-001397-nrq4ncdf 446 13 that that IN cord-001397-nrq4ncdf 446 14 the the DT cord-001397-nrq4ncdf 446 15 kidneys kidney NNS cord-001397-nrq4ncdf 446 16 could could MD cord-001397-nrq4ncdf 446 17 be be VB cord-001397-nrq4ncdf 446 18 an an DT cord-001397-nrq4ncdf 446 19 organ organ NN cord-001397-nrq4ncdf 446 20 preferred prefer VBN cord-001397-nrq4ncdf 446 21 for for IN cord-001397-nrq4ncdf 446 22 viral viral JJ cord-001397-nrq4ncdf 446 23 persistence persistence NN cord-001397-nrq4ncdf 446 24 . . . cord-001397-nrq4ncdf 447 1 C57BL/6J C57BL/6J NNP cord-001397-nrq4ncdf 447 2 mice mouse NNS cord-001397-nrq4ncdf 447 3 maintained maintain VBD cord-001397-nrq4ncdf 447 4 a a DT cord-001397-nrq4ncdf 447 5 persistent persistent JJ cord-001397-nrq4ncdf 447 6 WNV WNV NNP cord-001397-nrq4ncdf 447 7 infection infection NN cord-001397-nrq4ncdf 447 8 in in IN cord-001397-nrq4ncdf 447 9 the the DT cord-001397-nrq4ncdf 447 10 face face NN cord-001397-nrq4ncdf 447 11 of of IN cord-001397-nrq4ncdf 447 12 robust robust JJ cord-001397-nrq4ncdf 447 13 neutralizing neutralize VBG cord-001397-nrq4ncdf 447 14 antibody antibody NN cord-001397-nrq4ncdf 447 15 levels level NNS cord-001397-nrq4ncdf 447 16 for for IN cord-001397-nrq4ncdf 447 17 more more JJR cord-001397-nrq4ncdf 447 18 than than IN cord-001397-nrq4ncdf 447 19 6 6 CD cord-001397-nrq4ncdf 447 20 months month NNS cord-001397-nrq4ncdf 447 21 ( ( -LRB- cord-001397-nrq4ncdf 447 22 Appler Appler NNP cord-001397-nrq4ncdf 447 23 et et NNP cord-001397-nrq4ncdf 447 24 al al NNP cord-001397-nrq4ncdf 447 25 . . NNP cord-001397-nrq4ncdf 447 26 , , , cord-001397-nrq4ncdf 447 27 2010 2010 CD cord-001397-nrq4ncdf 447 28 ; ; : cord-001397-nrq4ncdf 447 29 Stewart Stewart NNP cord-001397-nrq4ncdf 447 30 et et NNP cord-001397-nrq4ncdf 447 31 al al NNP cord-001397-nrq4ncdf 447 32 . . NNP cord-001397-nrq4ncdf 447 33 , , , cord-001397-nrq4ncdf 447 34 2011 2011 CD cord-001397-nrq4ncdf 447 35 ) ) -RRB- cord-001397-nrq4ncdf 447 36 . . . cord-001397-nrq4ncdf 448 1 In in IN cord-001397-nrq4ncdf 448 2 this this DT cord-001397-nrq4ncdf 448 3 study study NN cord-001397-nrq4ncdf 448 4 , , , cord-001397-nrq4ncdf 448 5 infectious infectious JJ cord-001397-nrq4ncdf 448 6 virus virus NN cord-001397-nrq4ncdf 448 7 was be VBD cord-001397-nrq4ncdf 448 8 recovered recover VBN cord-001397-nrq4ncdf 448 9 in in IN cord-001397-nrq4ncdf 448 10 the the DT cord-001397-nrq4ncdf 448 11 skin skin NN cord-001397-nrq4ncdf 448 12 , , , cord-001397-nrq4ncdf 448 13 and and CC cord-001397-nrq4ncdf 448 14 viral viral JJ cord-001397-nrq4ncdf 448 15 RNA RNA NNP cord-001397-nrq4ncdf 448 16 was be VBD cord-001397-nrq4ncdf 448 17 identified identify VBN cord-001397-nrq4ncdf 448 18 in in IN cord-001397-nrq4ncdf 448 19 the the DT cord-001397-nrq4ncdf 448 20 skin skin NN cord-001397-nrq4ncdf 448 21 , , , cord-001397-nrq4ncdf 448 22 as as RB cord-001397-nrq4ncdf 448 23 well well RB cord-001397-nrq4ncdf 448 24 as as IN cord-001397-nrq4ncdf 448 25 the the DT cord-001397-nrq4ncdf 448 26 spinal spinal JJ cord-001397-nrq4ncdf 448 27 cord cord NN cord-001397-nrq4ncdf 448 28 and and CC cord-001397-nrq4ncdf 448 29 brain brain NN cord-001397-nrq4ncdf 448 30 ( ( -LRB- cord-001397-nrq4ncdf 448 31 Appler Appler NNP cord-001397-nrq4ncdf 448 32 et et NNP cord-001397-nrq4ncdf 448 33 al al NNP cord-001397-nrq4ncdf 448 34 . . NNP cord-001397-nrq4ncdf 448 35 , , , cord-001397-nrq4ncdf 448 36 2010 2010 CD cord-001397-nrq4ncdf 448 37 ) ) -RRB- cord-001397-nrq4ncdf 448 38 . . . cord-001397-nrq4ncdf 449 1 In in IN cord-001397-nrq4ncdf 449 2 contrast contrast NN cord-001397-nrq4ncdf 449 3 , , , cord-001397-nrq4ncdf 449 4 WNV WNV NNP cord-001397-nrq4ncdf 449 5 persistence persistence NN cord-001397-nrq4ncdf 449 6 was be VBD cord-001397-nrq4ncdf 449 7 uncommon uncommon JJ cord-001397-nrq4ncdf 449 8 in in IN cord-001397-nrq4ncdf 449 9 kidneys kidney NNS cord-001397-nrq4ncdf 449 10 and and CC cord-001397-nrq4ncdf 449 11 rare rare JJ cord-001397-nrq4ncdf 449 12 in in IN cord-001397-nrq4ncdf 449 13 the the DT cord-001397-nrq4ncdf 449 14 heart heart NN cord-001397-nrq4ncdf 450 1 ( ( -LRB- cord-001397-nrq4ncdf 450 2 Appler Appler NNP cord-001397-nrq4ncdf 450 3 et et NNP cord-001397-nrq4ncdf 450 4 al al NNP cord-001397-nrq4ncdf 450 5 . . NNP cord-001397-nrq4ncdf 450 6 , , , cord-001397-nrq4ncdf 450 7 2010 2010 CD cord-001397-nrq4ncdf 450 8 ) ) -RRB- cord-001397-nrq4ncdf 450 9 . . . cord-001397-nrq4ncdf 451 1 However however RB cord-001397-nrq4ncdf 451 2 , , , cord-001397-nrq4ncdf 451 3 in in IN cord-001397-nrq4ncdf 451 4 another another DT cord-001397-nrq4ncdf 451 5 study study NN cord-001397-nrq4ncdf 451 6 in in IN cord-001397-nrq4ncdf 451 7 which which WDT cord-001397-nrq4ncdf 451 8 C57BL/6J C57BL/6J NNP cord-001397-nrq4ncdf 451 9 mice mouse NNS cord-001397-nrq4ncdf 451 10 were be VBD cord-001397-nrq4ncdf 451 11 infected infect VBN cord-001397-nrq4ncdf 451 12 with with IN cord-001397-nrq4ncdf 451 13 WNV WNV NNP cord-001397-nrq4ncdf 451 14 derived derive VBN cord-001397-nrq4ncdf 451 15 from from IN cord-001397-nrq4ncdf 451 16 the the DT cord-001397-nrq4ncdf 451 17 urine urine NN cord-001397-nrq4ncdf 451 18 of of IN cord-001397-nrq4ncdf 451 19 persistently persistently RB cord-001397-nrq4ncdf 451 20 infected infect VBN cord-001397-nrq4ncdf 451 21 hamsters hamster NNS cord-001397-nrq4ncdf 451 22 , , , cord-001397-nrq4ncdf 451 23 the the DT cord-001397-nrq4ncdf 451 24 kidney kidney NN cord-001397-nrq4ncdf 451 25 was be VBD cord-001397-nrq4ncdf 451 26 found find VBN cord-001397-nrq4ncdf 451 27 to to TO cord-001397-nrq4ncdf 451 28 be be VB cord-001397-nrq4ncdf 451 29 the the DT cord-001397-nrq4ncdf 451 30 preferred preferred JJ cord-001397-nrq4ncdf 451 31 organ organ NN cord-001397-nrq4ncdf 451 32 for for IN cord-001397-nrq4ncdf 451 33 viral viral JJ cord-001397-nrq4ncdf 451 34 persistence persistence NN cord-001397-nrq4ncdf 451 35 ( ( -LRB- cord-001397-nrq4ncdf 452 1 Saxena Saxena NNP cord-001397-nrq4ncdf 452 2 et et NNP cord-001397-nrq4ncdf 452 3 al al NNP cord-001397-nrq4ncdf 452 4 . . . cord-001397-nrq4ncdf 453 1 , , , cord-001397-nrq4ncdf 453 2 2013 2013 CD cord-001397-nrq4ncdf 453 3 ) ) -RRB- cord-001397-nrq4ncdf 453 4 . . . cord-001397-nrq4ncdf 454 1 The the DT cord-001397-nrq4ncdf 454 2 hamster hamster NN cord-001397-nrq4ncdf 454 3 - - HYPH cord-001397-nrq4ncdf 454 4 derived derive VBN cord-001397-nrq4ncdf 454 5 WNV WNV NNP cord-001397-nrq4ncdf 454 6 was be VBD cord-001397-nrq4ncdf 454 7 also also RB cord-001397-nrq4ncdf 454 8 found find VBN cord-001397-nrq4ncdf 454 9 to to TO cord-001397-nrq4ncdf 454 10 be be VB cord-001397-nrq4ncdf 454 11 highly highly RB cord-001397-nrq4ncdf 454 12 attenuated attenuated JJ cord-001397-nrq4ncdf 454 13 in in IN cord-001397-nrq4ncdf 454 14 both both DT cord-001397-nrq4ncdf 454 15 neuroinvasiveness neuroinvasiveness NN cord-001397-nrq4ncdf 454 16 and and CC cord-001397-nrq4ncdf 454 17 neurovirulence neurovirulence NN cord-001397-nrq4ncdf 454 18 in in IN cord-001397-nrq4ncdf 454 19 infected infected JJ cord-001397-nrq4ncdf 454 20 mice mouse NNS cord-001397-nrq4ncdf 454 21 ( ( -LRB- cord-001397-nrq4ncdf 455 1 Saxena Saxena NNP cord-001397-nrq4ncdf 455 2 et et NNP cord-001397-nrq4ncdf 455 3 al al NNP cord-001397-nrq4ncdf 455 4 . . . cord-001397-nrq4ncdf 456 1 , , , cord-001397-nrq4ncdf 456 2 2013 2013 CD cord-001397-nrq4ncdf 456 3 ) ) -RRB- cord-001397-nrq4ncdf 456 4 . . . cord-001397-nrq4ncdf 457 1 These these DT cord-001397-nrq4ncdf 457 2 results result NNS cord-001397-nrq4ncdf 457 3 also also RB cord-001397-nrq4ncdf 457 4 suggest suggest VBP cord-001397-nrq4ncdf 457 5 that that IN cord-001397-nrq4ncdf 457 6 the the DT cord-001397-nrq4ncdf 457 7 virus virus NN cord-001397-nrq4ncdf 457 8 acquires acquire VBZ cord-001397-nrq4ncdf 457 9 phenotypic phenotypic JJ cord-001397-nrq4ncdf 457 10 changes change NNS cord-001397-nrq4ncdf 457 11 to to TO cord-001397-nrq4ncdf 457 12 be be VB cord-001397-nrq4ncdf 457 13 able able JJ cord-001397-nrq4ncdf 457 14 to to TO cord-001397-nrq4ncdf 457 15 persist persist VB cord-001397-nrq4ncdf 457 16 . . . cord-001397-nrq4ncdf 458 1 While while IN cord-001397-nrq4ncdf 458 2 the the DT cord-001397-nrq4ncdf 458 3 inbred inbred JJ cord-001397-nrq4ncdf 458 4 laboratory laboratory NN cord-001397-nrq4ncdf 458 5 mouse mouse NN cord-001397-nrq4ncdf 458 6 models model NNS cord-001397-nrq4ncdf 458 7 are be VBP cord-001397-nrq4ncdf 458 8 patently patently RB cord-001397-nrq4ncdf 458 9 useful useful JJ cord-001397-nrq4ncdf 458 10 for for IN cord-001397-nrq4ncdf 458 11 understanding understand VBG cord-001397-nrq4ncdf 458 12 some some DT cord-001397-nrq4ncdf 458 13 aspects aspect NNS cord-001397-nrq4ncdf 458 14 of of IN cord-001397-nrq4ncdf 458 15 flavivirus flavivirus JJ cord-001397-nrq4ncdf 458 16 persistence persistence NN cord-001397-nrq4ncdf 458 17 , , , cord-001397-nrq4ncdf 458 18 very very RB cord-001397-nrq4ncdf 458 19 few few JJ cord-001397-nrq4ncdf 458 20 natural natural JJ cord-001397-nrq4ncdf 458 21 rodent rodent NN cord-001397-nrq4ncdf 458 22 hosts host NNS cord-001397-nrq4ncdf 458 23 have have VBP cord-001397-nrq4ncdf 458 24 been be VBN cord-001397-nrq4ncdf 458 25 established establish VBN cord-001397-nrq4ncdf 458 26 as as IN cord-001397-nrq4ncdf 458 27 experimental experimental JJ cord-001397-nrq4ncdf 458 28 animal animal NN cord-001397-nrq4ncdf 458 29 models model NNS cord-001397-nrq4ncdf 458 30 . . . cord-001397-nrq4ncdf 459 1 Evidence evidence NN cord-001397-nrq4ncdf 459 2 of of IN cord-001397-nrq4ncdf 459 3 exposure exposure NN cord-001397-nrq4ncdf 459 4 to to IN cord-001397-nrq4ncdf 459 5 WNV WNV NNP cord-001397-nrq4ncdf 459 6 has have VBZ cord-001397-nrq4ncdf 459 7 been be VBN cord-001397-nrq4ncdf 459 8 reported report VBN cord-001397-nrq4ncdf 459 9 in in IN cord-001397-nrq4ncdf 459 10 rodent rodent NN cord-001397-nrq4ncdf 459 11 species specie NNS cord-001397-nrq4ncdf 459 12 , , , cord-001397-nrq4ncdf 459 13 such such JJ cord-001397-nrq4ncdf 459 14 as as IN cord-001397-nrq4ncdf 459 15 rats rat NNS cord-001397-nrq4ncdf 459 16 ( ( -LRB- cord-001397-nrq4ncdf 459 17 Rattus Rattus NNP cord-001397-nrq4ncdf 459 18 ) ) -RRB- cord-001397-nrq4ncdf 459 19 , , , cord-001397-nrq4ncdf 459 20 bank bank NN cord-001397-nrq4ncdf 459 21 voles vole NNS cord-001397-nrq4ncdf 459 22 ( ( -LRB- cord-001397-nrq4ncdf 459 23 M. M. NNP cord-001397-nrq4ncdf 459 24 glareolus glareolus NNP cord-001397-nrq4ncdf 459 25 ) ) -RRB- cord-001397-nrq4ncdf 459 26 , , , cord-001397-nrq4ncdf 459 27 and and CC cord-001397-nrq4ncdf 459 28 deer deer NN cord-001397-nrq4ncdf 459 29 mice mouse NNS cord-001397-nrq4ncdf 459 30 ( ( -LRB- cord-001397-nrq4ncdf 459 31 Peromyscus Peromyscus NNP cord-001397-nrq4ncdf 459 32 ; ; : cord-001397-nrq4ncdf 459 33 Molnar Molnar NNP cord-001397-nrq4ncdf 459 34 et et NNP cord-001397-nrq4ncdf 459 35 al al NNP cord-001397-nrq4ncdf 459 36 . . NNP cord-001397-nrq4ncdf 459 37 , , , cord-001397-nrq4ncdf 459 38 1976 1976 CD cord-001397-nrq4ncdf 459 39 ; ; : cord-001397-nrq4ncdf 459 40 Root Root NNP cord-001397-nrq4ncdf 459 41 et et FW cord-001397-nrq4ncdf 459 42 al al NNP cord-001397-nrq4ncdf 459 43 . . NNP cord-001397-nrq4ncdf 459 44 , , , cord-001397-nrq4ncdf 459 45 2005 2005 CD cord-001397-nrq4ncdf 459 46 ; ; : cord-001397-nrq4ncdf 459 47 Docherty Docherty NNP cord-001397-nrq4ncdf 459 48 et et NNP cord-001397-nrq4ncdf 459 49 al al NNP cord-001397-nrq4ncdf 459 50 . . NNP cord-001397-nrq4ncdf 459 51 , , , cord-001397-nrq4ncdf 459 52 2006 2006 CD cord-001397-nrq4ncdf 459 53 ; ; : cord-001397-nrq4ncdf 459 54 Gomez Gomez NNP cord-001397-nrq4ncdf 459 55 et et NNP cord-001397-nrq4ncdf 459 56 al al NNP cord-001397-nrq4ncdf 459 57 . . NNP cord-001397-nrq4ncdf 459 58 , , , cord-001397-nrq4ncdf 459 59 2008 2008 CD cord-001397-nrq4ncdf 459 60 ) ) -RRB- cord-001397-nrq4ncdf 459 61 . . . cord-001397-nrq4ncdf 460 1 However however RB cord-001397-nrq4ncdf 460 2 , , , cord-001397-nrq4ncdf 460 3 infectious infectious JJ cord-001397-nrq4ncdf 460 4 virus virus NN cord-001397-nrq4ncdf 460 5 was be VBD cord-001397-nrq4ncdf 460 6 only only RB cord-001397-nrq4ncdf 460 7 identified identify VBN cord-001397-nrq4ncdf 460 8 in in IN cord-001397-nrq4ncdf 460 9 the the DT cord-001397-nrq4ncdf 460 10 bank bank NN cord-001397-nrq4ncdf 460 11 vole vole NN cord-001397-nrq4ncdf 460 12 , , , cord-001397-nrq4ncdf 460 13 whereas whereas IN cord-001397-nrq4ncdf 460 14 antibodies antibody NNS cord-001397-nrq4ncdf 460 15 were be VBD cord-001397-nrq4ncdf 460 16 detected detect VBN cord-001397-nrq4ncdf 460 17 in in IN cord-001397-nrq4ncdf 460 18 all all DT cord-001397-nrq4ncdf 460 19 of of IN cord-001397-nrq4ncdf 460 20 the the DT cord-001397-nrq4ncdf 460 21 species specie NNS cord-001397-nrq4ncdf 460 22 ( ( -LRB- cord-001397-nrq4ncdf 461 1 Molnar Molnar NNP cord-001397-nrq4ncdf 461 2 et et NNP cord-001397-nrq4ncdf 461 3 al al NNP cord-001397-nrq4ncdf 461 4 . . NNP cord-001397-nrq4ncdf 461 5 , , , cord-001397-nrq4ncdf 461 6 1976 1976 CD cord-001397-nrq4ncdf 462 1 ; ; : cord-001397-nrq4ncdf 462 2 Root Root NNP cord-001397-nrq4ncdf 462 3 et et FW cord-001397-nrq4ncdf 462 4 al al NNP cord-001397-nrq4ncdf 462 5 . . NNP cord-001397-nrq4ncdf 462 6 , , , cord-001397-nrq4ncdf 462 7 2005 2005 CD cord-001397-nrq4ncdf 462 8 ) ) -RRB- cord-001397-nrq4ncdf 462 9 . . . cord-001397-nrq4ncdf 463 1 Although although IN cord-001397-nrq4ncdf 463 2 persistence persistence NN cord-001397-nrq4ncdf 463 3 in in IN cord-001397-nrq4ncdf 463 4 mammals mammal NNS cord-001397-nrq4ncdf 463 5 obviously obviously RB cord-001397-nrq4ncdf 463 6 plays play VBZ cord-001397-nrq4ncdf 463 7 a a DT cord-001397-nrq4ncdf 463 8 significant significant JJ cord-001397-nrq4ncdf 463 9 role role NN cord-001397-nrq4ncdf 463 10 in in IN cord-001397-nrq4ncdf 463 11 TBFV TBFV NNP cord-001397-nrq4ncdf 463 12 infections infection NNS cord-001397-nrq4ncdf 463 13 , , , cord-001397-nrq4ncdf 463 14 little little JJ cord-001397-nrq4ncdf 463 15 attention attention NN cord-001397-nrq4ncdf 463 16 has have VBZ cord-001397-nrq4ncdf 463 17 been be VBN cord-001397-nrq4ncdf 463 18 devoted devote VBN cord-001397-nrq4ncdf 463 19 to to IN cord-001397-nrq4ncdf 463 20 experimental experimental JJ cord-001397-nrq4ncdf 463 21 studies study NNS cord-001397-nrq4ncdf 463 22 of of IN cord-001397-nrq4ncdf 463 23 this this DT cord-001397-nrq4ncdf 463 24 aspect aspect NN cord-001397-nrq4ncdf 463 25 of of IN cord-001397-nrq4ncdf 463 26 TBFV TBFV NNP cord-001397-nrq4ncdf 463 27 biology biology NN cord-001397-nrq4ncdf 463 28 . . . cord-001397-nrq4ncdf 464 1 While while IN cord-001397-nrq4ncdf 464 2 disease disease NN cord-001397-nrq4ncdf 464 3 or or CC cord-001397-nrq4ncdf 464 4 therapy therapy NN cord-001397-nrq4ncdf 464 5 models model NNS cord-001397-nrq4ncdf 464 6 have have VBP cord-001397-nrq4ncdf 464 7 been be VBN cord-001397-nrq4ncdf 464 8 established establish VBN cord-001397-nrq4ncdf 464 9 for for IN cord-001397-nrq4ncdf 464 10 TBFVs tbfv NNS cord-001397-nrq4ncdf 464 11 ( ( -LRB- cord-001397-nrq4ncdf 464 12 Kreil Kreil NNP cord-001397-nrq4ncdf 464 13 et et NNP cord-001397-nrq4ncdf 464 14 al al NNP cord-001397-nrq4ncdf 464 15 . . NNP cord-001397-nrq4ncdf 464 16 , , , cord-001397-nrq4ncdf 464 17 1997 1997 CD cord-001397-nrq4ncdf 464 18 ; ; : cord-001397-nrq4ncdf 464 19 Holbrook Holbrook NNP cord-001397-nrq4ncdf 464 20 et et NNP cord-001397-nrq4ncdf 464 21 al al NNP cord-001397-nrq4ncdf 464 22 . . . cord-001397-nrq4ncdf 465 1 , , , cord-001397-nrq4ncdf 465 2 2005 2005 CD cord-001397-nrq4ncdf 465 3 ; ; : cord-001397-nrq4ncdf 465 4 Hayasaka Hayasaka NNP cord-001397-nrq4ncdf 465 5 et et NNP cord-001397-nrq4ncdf 465 6 al al NNP cord-001397-nrq4ncdf 465 7 . . NNP cord-001397-nrq4ncdf 465 8 , , , cord-001397-nrq4ncdf 465 9 2010 2010 CD cord-001397-nrq4ncdf 465 10 ; ; : cord-001397-nrq4ncdf 465 11 Palus Palus NNP cord-001397-nrq4ncdf 465 12 et et NNP cord-001397-nrq4ncdf 465 13 al al NNP cord-001397-nrq4ncdf 465 14 . . . cord-001397-nrq4ncdf 466 1 , , , cord-001397-nrq4ncdf 466 2 2013 2013 CD cord-001397-nrq4ncdf 466 3 ) ) -RRB- cord-001397-nrq4ncdf 466 4 , , , cord-001397-nrq4ncdf 466 5 none none NN cord-001397-nrq4ncdf 466 6 of of IN cord-001397-nrq4ncdf 466 7 these these DT cord-001397-nrq4ncdf 466 8 specifically specifically RB cord-001397-nrq4ncdf 466 9 investigated investigate VBN cord-001397-nrq4ncdf 466 10 viral viral JJ cord-001397-nrq4ncdf 466 11 persistence persistence NN cord-001397-nrq4ncdf 466 12 . . . cord-001397-nrq4ncdf 467 1 Experiments experiment NNS cord-001397-nrq4ncdf 467 2 to to TO cord-001397-nrq4ncdf 467 3 determine determine VB cord-001397-nrq4ncdf 467 4 the the DT cord-001397-nrq4ncdf 467 5 susceptibility susceptibility NN cord-001397-nrq4ncdf 467 6 of of IN cord-001397-nrq4ncdf 467 7 several several JJ cord-001397-nrq4ncdf 467 8 wild wild JJ cord-001397-nrq4ncdf 467 9 and and CC cord-001397-nrq4ncdf 467 10 domesticated domesticated JJ cord-001397-nrq4ncdf 467 11 mammals mammal NNS cord-001397-nrq4ncdf 467 12 to to IN cord-001397-nrq4ncdf 467 13 POWV POWV NNP cord-001397-nrq4ncdf 467 14 showed show VBD cord-001397-nrq4ncdf 467 15 that that IN cord-001397-nrq4ncdf 467 16 viremia viremia NN cord-001397-nrq4ncdf 467 17 lasted last VBD cord-001397-nrq4ncdf 467 18 for for IN cord-001397-nrq4ncdf 467 19 0 0 CD cord-001397-nrq4ncdf 467 20 - - SYM cord-001397-nrq4ncdf 467 21 3 3 CD cord-001397-nrq4ncdf 467 22 days day NNS cord-001397-nrq4ncdf 467 23 in in IN cord-001397-nrq4ncdf 467 24 the the DT cord-001397-nrq4ncdf 467 25 goat goat NN cord-001397-nrq4ncdf 467 26 , , , cord-001397-nrq4ncdf 467 27 pig pig NN cord-001397-nrq4ncdf 467 28 , , , cord-001397-nrq4ncdf 467 29 skunk skunk NN cord-001397-nrq4ncdf 467 30 , , , cord-001397-nrq4ncdf 467 31 red red NNP cord-001397-nrq4ncdf 467 32 fox fox NNP cord-001397-nrq4ncdf 467 33 , , , cord-001397-nrq4ncdf 467 34 and and CC cord-001397-nrq4ncdf 467 35 gray gray NNP cord-001397-nrq4ncdf 467 36 fox fox NNP cord-001397-nrq4ncdf 467 37 ( ( -LRB- cord-001397-nrq4ncdf 467 38 Yiang Yiang NNP cord-001397-nrq4ncdf 467 39 et et NNP cord-001397-nrq4ncdf 467 40 al al NNP cord-001397-nrq4ncdf 467 41 . . NNP cord-001397-nrq4ncdf 467 42 , , , cord-001397-nrq4ncdf 467 43 2013 2013 CD cord-001397-nrq4ncdf 467 44 ) ) -RRB- cord-001397-nrq4ncdf 467 45 . . . cord-001397-nrq4ncdf 468 1 In in IN cord-001397-nrq4ncdf 468 2 another another DT cord-001397-nrq4ncdf 468 3 study study NN cord-001397-nrq4ncdf 468 4 , , , cord-001397-nrq4ncdf 468 5 adult adult NN cord-001397-nrq4ncdf 468 6 deer deer NN cord-001397-nrq4ncdf 468 7 mice mouse NNS cord-001397-nrq4ncdf 468 8 ( ( -LRB- cord-001397-nrq4ncdf 468 9 Peromoyscus Peromoyscus NNP cord-001397-nrq4ncdf 468 10 leucopus leucopus NNP cord-001397-nrq4ncdf 468 11 ) ) -RRB- cord-001397-nrq4ncdf 468 12 survived survive VBD cord-001397-nrq4ncdf 468 13 challenge challenge NN cord-001397-nrq4ncdf 468 14 with with IN cord-001397-nrq4ncdf 468 15 POWV POWV NNP cord-001397-nrq4ncdf 468 16 without without IN cord-001397-nrq4ncdf 468 17 apparent apparent JJ cord-001397-nrq4ncdf 468 18 illness illness NN cord-001397-nrq4ncdf 468 19 , , , cord-001397-nrq4ncdf 468 20 but but CC cord-001397-nrq4ncdf 468 21 evidence evidence NN cord-001397-nrq4ncdf 468 22 of of IN cord-001397-nrq4ncdf 468 23 viral viral JJ cord-001397-nrq4ncdf 468 24 persistence persistence NN cord-001397-nrq4ncdf 468 25 was be VBD cord-001397-nrq4ncdf 468 26 not not RB cord-001397-nrq4ncdf 468 27 sought seek VBN cord-001397-nrq4ncdf 468 28 ( ( -LRB- cord-001397-nrq4ncdf 468 29 Telford Telford NNP cord-001397-nrq4ncdf 468 30 et et NNP cord-001397-nrq4ncdf 468 31 al al NNP cord-001397-nrq4ncdf 468 32 . . NNP cord-001397-nrq4ncdf 468 33 , , , cord-001397-nrq4ncdf 468 34 1997 1997 CD cord-001397-nrq4ncdf 468 35 ) ) -RRB- cord-001397-nrq4ncdf 468 36 . . . cord-001397-nrq4ncdf 469 1 Development development NN cord-001397-nrq4ncdf 469 2 of of IN cord-001397-nrq4ncdf 469 3 suitable suitable JJ cord-001397-nrq4ncdf 469 4 experimental experimental JJ cord-001397-nrq4ncdf 469 5 models model NNS cord-001397-nrq4ncdf 469 6 for for IN cord-001397-nrq4ncdf 469 7 persistent persistent JJ cord-001397-nrq4ncdf 469 8 TBFV TBFV NNP cord-001397-nrq4ncdf 469 9 infection infection NN cord-001397-nrq4ncdf 469 10 would would MD cord-001397-nrq4ncdf 469 11 clearly clearly RB cord-001397-nrq4ncdf 469 12 provide provide VB cord-001397-nrq4ncdf 469 13 useful useful JJ cord-001397-nrq4ncdf 469 14 information information NN cord-001397-nrq4ncdf 469 15 about about IN cord-001397-nrq4ncdf 469 16 this this DT cord-001397-nrq4ncdf 469 17 aspect aspect NN cord-001397-nrq4ncdf 469 18 of of IN cord-001397-nrq4ncdf 469 19 these these DT cord-001397-nrq4ncdf 469 20 important important JJ cord-001397-nrq4ncdf 469 21 pathogens pathogen NNS cord-001397-nrq4ncdf 469 22 . . . cord-001397-nrq4ncdf 470 1 The the DT cord-001397-nrq4ncdf 470 2 previous previous JJ cord-001397-nrq4ncdf 470 3 sections section NNS cord-001397-nrq4ncdf 470 4 have have VBP cord-001397-nrq4ncdf 470 5 looked look VBN cord-001397-nrq4ncdf 470 6 at at IN cord-001397-nrq4ncdf 470 7 flavivirus flavivirus JJ cord-001397-nrq4ncdf 470 8 persistence persistence NN cord-001397-nrq4ncdf 470 9 in in IN cord-001397-nrq4ncdf 470 10 humans human NNS cord-001397-nrq4ncdf 470 11 , , , cord-001397-nrq4ncdf 470 12 animals animal NNS cord-001397-nrq4ncdf 470 13 , , , cord-001397-nrq4ncdf 470 14 and and CC cord-001397-nrq4ncdf 470 15 arthropod arthropod NN cord-001397-nrq4ncdf 470 16 vectors vector NNS cord-001397-nrq4ncdf 470 17 , , , cord-001397-nrq4ncdf 470 18 as as RB cord-001397-nrq4ncdf 470 19 well well RB cord-001397-nrq4ncdf 470 20 as as IN cord-001397-nrq4ncdf 470 21 some some DT cord-001397-nrq4ncdf 470 22 relevant relevant JJ cord-001397-nrq4ncdf 470 23 animal animal NN cord-001397-nrq4ncdf 470 24 models model NNS cord-001397-nrq4ncdf 470 25 . . . cord-001397-nrq4ncdf 471 1 In in IN cord-001397-nrq4ncdf 471 2 this this DT cord-001397-nrq4ncdf 471 3 section section NN cord-001397-nrq4ncdf 471 4 , , , cord-001397-nrq4ncdf 471 5 we -PRON- PRP cord-001397-nrq4ncdf 471 6 will will MD cord-001397-nrq4ncdf 471 7 survey survey VB cord-001397-nrq4ncdf 471 8 information information NN cord-001397-nrq4ncdf 471 9 related relate VBN cord-001397-nrq4ncdf 471 10 to to IN cord-001397-nrq4ncdf 471 11 the the DT cord-001397-nrq4ncdf 471 12 initiation initiation NN cord-001397-nrq4ncdf 471 13 and and CC cord-001397-nrq4ncdf 471 14 maintenance maintenance NN cord-001397-nrq4ncdf 471 15 of of IN cord-001397-nrq4ncdf 471 16 persistence persistence NN cord-001397-nrq4ncdf 471 17 . . . cord-001397-nrq4ncdf 472 1 When when WRB cord-001397-nrq4ncdf 472 2 mammalian mammalian JJ cord-001397-nrq4ncdf 472 3 cell cell NN cord-001397-nrq4ncdf 472 4 cultures culture NNS cord-001397-nrq4ncdf 472 5 are be VBP cord-001397-nrq4ncdf 472 6 acutely acutely RB cord-001397-nrq4ncdf 472 7 infected infect VBN cord-001397-nrq4ncdf 472 8 with with IN cord-001397-nrq4ncdf 472 9 TBFV TBFV NNP cord-001397-nrq4ncdf 472 10 , , , cord-001397-nrq4ncdf 472 11 a a DT cord-001397-nrq4ncdf 472 12 legion legion NN cord-001397-nrq4ncdf 472 13 of of IN cord-001397-nrq4ncdf 472 14 general general JJ cord-001397-nrq4ncdf 472 15 cellular cellular JJ cord-001397-nrq4ncdf 472 16 defense defense NN cord-001397-nrq4ncdf 472 17 and and CC cord-001397-nrq4ncdf 472 18 antiviral antiviral JJ cord-001397-nrq4ncdf 472 19 systems system NNS cord-001397-nrq4ncdf 472 20 are be VBP cord-001397-nrq4ncdf 472 21 triggered trigger VBN cord-001397-nrq4ncdf 472 22 , , , cord-001397-nrq4ncdf 472 23 as as IN cord-001397-nrq4ncdf 472 24 are be VBP cord-001397-nrq4ncdf 472 25 specific specific JJ cord-001397-nrq4ncdf 472 26 factors factor NNS cord-001397-nrq4ncdf 472 27 designed design VBN cord-001397-nrq4ncdf 472 28 to to TO cord-001397-nrq4ncdf 472 29 limit limit VB cord-001397-nrq4ncdf 472 30 or or CC cord-001397-nrq4ncdf 472 31 restrict restrict VB cord-001397-nrq4ncdf 472 32 virus virus NN cord-001397-nrq4ncdf 472 33 reproduction reproduction NN cord-001397-nrq4ncdf 472 34 . . . cord-001397-nrq4ncdf 473 1 Some some DT cord-001397-nrq4ncdf 473 2 of of IN cord-001397-nrq4ncdf 473 3 these these DT cord-001397-nrq4ncdf 473 4 include include VBP cord-001397-nrq4ncdf 473 5 type type NN cord-001397-nrq4ncdf 474 1 I -PRON- PRP cord-001397-nrq4ncdf 475 1 interferon interferon NNP cord-001397-nrq4ncdf 475 2 ( ( -LRB- cord-001397-nrq4ncdf 475 3 IFN IFN NNP cord-001397-nrq4ncdf 475 4 - - HYPH cord-001397-nrq4ncdf 475 5 a a NNP cord-001397-nrq4ncdf 475 6 / / SYM cord-001397-nrq4ncdf 475 7 IFN IFN NNP cord-001397-nrq4ncdf 475 8 - - HYPH cord-001397-nrq4ncdf 475 9 b b NNP cord-001397-nrq4ncdf 475 10 ) ) -RRB- cord-001397-nrq4ncdf 476 1 , , , cord-001397-nrq4ncdf 476 2 type type NN cord-001397-nrq4ncdf 476 3 III iii CD cord-001397-nrq4ncdf 476 4 interferon interferon NN cord-001397-nrq4ncdf 476 5 ( ( -LRB- cord-001397-nrq4ncdf 476 6 IFN IFN NNP cord-001397-nrq4ncdf 476 7 - - HYPH cord-001397-nrq4ncdf 476 8 k k NNP cord-001397-nrq4ncdf 476 9 ) ) -RRB- cord-001397-nrq4ncdf 476 10 , , . cord-001397-nrq4ncdf 477 1 mitochondrial mitochondrial NN cord-001397-nrq4ncdf 477 2 activated activate VBD cord-001397-nrq4ncdf 477 3 signaling signal VBG cord-001397-nrq4ncdf 477 4 , , , cord-001397-nrq4ncdf 477 5 and and CC cord-001397-nrq4ncdf 477 6 the the DT cord-001397-nrq4ncdf 477 7 induction induction NN cord-001397-nrq4ncdf 477 8 of of IN cord-001397-nrq4ncdf 477 9 inflammatory inflammatory JJ cord-001397-nrq4ncdf 477 10 factors factor NNS cord-001397-nrq4ncdf 477 11 , , , cord-001397-nrq4ncdf 477 12 such such JJ cord-001397-nrq4ncdf 477 13 as as IN cord-001397-nrq4ncdf 477 14 interleukins interleukin NNS cord-001397-nrq4ncdf 477 15 ( ( -LRB- cord-001397-nrq4ncdf 477 16 Tam Tam NNP cord-001397-nrq4ncdf 477 17 & & CC cord-001397-nrq4ncdf 477 18 Messner Messner NNP cord-001397-nrq4ncdf 477 19 , , , cord-001397-nrq4ncdf 477 20 1999 1999 CD cord-001397-nrq4ncdf 477 21 ; ; : cord-001397-nrq4ncdf 477 22 Madden Madden NNP cord-001397-nrq4ncdf 477 23 , , , cord-001397-nrq4ncdf 477 24 2003 2003 CD cord-001397-nrq4ncdf 477 25 ; ; : cord-001397-nrq4ncdf 477 26 Van Van NNP cord-001397-nrq4ncdf 477 27 Gerpen Gerpen NNP cord-001397-nrq4ncdf 477 28 , , , cord-001397-nrq4ncdf 477 29 2003 2003 CD cord-001397-nrq4ncdf 477 30 ) ) -RRB- cord-001397-nrq4ncdf 477 31 . . . cord-001397-nrq4ncdf 478 1 For for IN cord-001397-nrq4ncdf 478 2 example example NN cord-001397-nrq4ncdf 478 3 , , , cord-001397-nrq4ncdf 478 4 the the DT cord-001397-nrq4ncdf 478 5 IFN IFN NNP cord-001397-nrq4ncdf 478 6 - - HYPH cord-001397-nrq4ncdf 478 7 induced induce VBN cord-001397-nrq4ncdf 478 8 tripartite tripartite JJ cord-001397-nrq4ncdf 478 9 motif motif NN cord-001397-nrq4ncdf 478 10 protein protein NN cord-001397-nrq4ncdf 478 11 , , , cord-001397-nrq4ncdf 478 12 TRIM79a TRIM79a NNP cord-001397-nrq4ncdf 478 13 , , , cord-001397-nrq4ncdf 478 14 has have VBZ cord-001397-nrq4ncdf 478 15 been be VBN cord-001397-nrq4ncdf 478 16 shown show VBN cord-001397-nrq4ncdf 478 17 to to TO cord-001397-nrq4ncdf 478 18 restrict restrict VB cord-001397-nrq4ncdf 478 19 TBEV TBEV NNP cord-001397-nrq4ncdf 478 20 replication replication NN cord-001397-nrq4ncdf 478 21 by by IN cord-001397-nrq4ncdf 478 22 degrading degrade VBG cord-001397-nrq4ncdf 478 23 NS5 NS5 NNP cord-001397-nrq4ncdf 478 24 ( ( -LRB- cord-001397-nrq4ncdf 478 25 Taylor Taylor NNP cord-001397-nrq4ncdf 478 26 et et NNP cord-001397-nrq4ncdf 478 27 al al NNP cord-001397-nrq4ncdf 478 28 . . NNP cord-001397-nrq4ncdf 478 29 , , , cord-001397-nrq4ncdf 478 30 2011 2011 CD cord-001397-nrq4ncdf 478 31 ) ) -RRB- cord-001397-nrq4ncdf 478 32 . . . cord-001397-nrq4ncdf 479 1 The the DT cord-001397-nrq4ncdf 479 2 unimpeded unimpeded JJ cord-001397-nrq4ncdf 479 3 deployment deployment NN cord-001397-nrq4ncdf 479 4 of of IN cord-001397-nrq4ncdf 479 5 these these DT cord-001397-nrq4ncdf 479 6 antiviral antiviral JJ cord-001397-nrq4ncdf 479 7 factors factor NNS cord-001397-nrq4ncdf 479 8 and and CC cord-001397-nrq4ncdf 479 9 systems system NNS cord-001397-nrq4ncdf 479 10 would would MD cord-001397-nrq4ncdf 479 11 lead lead VB cord-001397-nrq4ncdf 479 12 to to IN cord-001397-nrq4ncdf 479 13 cell cell NN cord-001397-nrq4ncdf 479 14 death death NN cord-001397-nrq4ncdf 479 15 . . . cord-001397-nrq4ncdf 480 1 Cell cell NN cord-001397-nrq4ncdf 480 2 death death NN cord-001397-nrq4ncdf 480 3 is be VBZ cord-001397-nrq4ncdf 480 4 thought think VBN cord-001397-nrq4ncdf 480 5 to to TO cord-001397-nrq4ncdf 480 6 be be VB cord-001397-nrq4ncdf 480 7 mediated mediate VBN cord-001397-nrq4ncdf 480 8 primarily primarily RB cord-001397-nrq4ncdf 480 9 through through IN cord-001397-nrq4ncdf 480 10 apoptosis apoptosis NN cord-001397-nrq4ncdf 480 11 ( ( -LRB- cord-001397-nrq4ncdf 480 12 R r NN cord-001397-nrq4ncdf 480 13 u u NN cord-001397-nrq4ncdf 480 14 zek zek NNP cord-001397-nrq4ncdf 480 15 et et NNP cord-001397-nrq4ncdf 480 16 al al NNP cord-001397-nrq4ncdf 480 17 . . NNP cord-001397-nrq4ncdf 480 18 , , , cord-001397-nrq4ncdf 480 19 2009 2009 CD cord-001397-nrq4ncdf 480 20 ) ) -RRB- cord-001397-nrq4ncdf 480 21 , , , cord-001397-nrq4ncdf 480 22 and and CC cord-001397-nrq4ncdf 480 23 programmed program VBD cord-001397-nrq4ncdf 480 24 cell cell NN cord-001397-nrq4ncdf 480 25 death death NN cord-001397-nrq4ncdf 480 26 induced induce VBN cord-001397-nrq4ncdf 480 27 by by IN cord-001397-nrq4ncdf 480 28 various various JJ cord-001397-nrq4ncdf 480 29 TBFVs tbfvs NN cord-001397-nrq4ncdf 480 30 has have VBZ cord-001397-nrq4ncdf 480 31 been be VBN cord-001397-nrq4ncdf 480 32 described describe VBN cord-001397-nrq4ncdf 480 33 in in IN cord-001397-nrq4ncdf 480 34 neurons neuron NNS cord-001397-nrq4ncdf 480 35 , , , cord-001397-nrq4ncdf 480 36 epithelial epithelial JJ cord-001397-nrq4ncdf 480 37 cells cell NNS cord-001397-nrq4ncdf 480 38 , , , cord-001397-nrq4ncdf 480 39 hepatocytes hepatocyte NNS cord-001397-nrq4ncdf 480 40 , , , cord-001397-nrq4ncdf 480 41 Kupffer Kupffer NNP cord-001397-nrq4ncdf 480 42 cells cell NNS cord-001397-nrq4ncdf 480 43 , , , cord-001397-nrq4ncdf 480 44 and and CC cord-001397-nrq4ncdf 480 45 neuroblastoma neuroblastoma NN cord-001397-nrq4ncdf 480 46 cells cell NNS cord-001397-nrq4ncdf 480 47 ( ( -LRB- cord-001397-nrq4ncdf 480 48 Ramanathan Ramanathan NNP cord-001397-nrq4ncdf 480 49 et et NNP cord-001397-nrq4ncdf 480 50 al al NNP cord-001397-nrq4ncdf 480 51 . . NNP cord-001397-nrq4ncdf 480 52 , , , cord-001397-nrq4ncdf 480 53 2006 2006 CD cord-001397-nrq4ncdf 480 54 ) ) -RRB- cord-001397-nrq4ncdf 480 55 . . . cord-001397-nrq4ncdf 481 1 Impeding impede VBG cord-001397-nrq4ncdf 481 2 or or CC cord-001397-nrq4ncdf 481 3 evading evade VBG cord-001397-nrq4ncdf 481 4 the the DT cord-001397-nrq4ncdf 481 5 antiviral antiviral JJ cord-001397-nrq4ncdf 481 6 response response NN cord-001397-nrq4ncdf 481 7 is be VBZ cord-001397-nrq4ncdf 481 8 one one CD cord-001397-nrq4ncdf 481 9 characteristic characteristic NN cord-001397-nrq4ncdf 481 10 of of IN cord-001397-nrq4ncdf 481 11 VBFVs vbfv NNS cord-001397-nrq4ncdf 481 12 , , , cord-001397-nrq4ncdf 481 13 which which WDT cord-001397-nrq4ncdf 481 14 plays play VBZ cord-001397-nrq4ncdf 481 15 an an DT cord-001397-nrq4ncdf 481 16 important important JJ cord-001397-nrq4ncdf 481 17 role role NN cord-001397-nrq4ncdf 481 18 in in IN cord-001397-nrq4ncdf 481 19 viral viral JJ cord-001397-nrq4ncdf 481 20 persistence persistence NN cord-001397-nrq4ncdf 481 21 . . . cord-001397-nrq4ncdf 482 1 During during IN cord-001397-nrq4ncdf 482 2 flavivirus flavivirus JJ cord-001397-nrq4ncdf 482 3 infection infection NN cord-001397-nrq4ncdf 482 4 , , , cord-001397-nrq4ncdf 482 5 IFN IFN NNP cord-001397-nrq4ncdf 482 6 production production NN cord-001397-nrq4ncdf 482 7 is be VBZ cord-001397-nrq4ncdf 482 8 induced induce VBN cord-001397-nrq4ncdf 482 9 within within IN cord-001397-nrq4ncdf 482 10 hours hour NNS cord-001397-nrq4ncdf 482 11 , , , cord-001397-nrq4ncdf 482 12 but but CC cord-001397-nrq4ncdf 482 13 viral viral JJ cord-001397-nrq4ncdf 482 14 RNA RNA NNP cord-001397-nrq4ncdf 482 15 replication replication NN cord-001397-nrq4ncdf 482 16 complexes complex NNS cord-001397-nrq4ncdf 482 17 are be VBP cord-001397-nrq4ncdf 482 18 enclosed enclose VBN cord-001397-nrq4ncdf 482 19 in in IN cord-001397-nrq4ncdf 482 20 vesicles vesicle NNS cord-001397-nrq4ncdf 482 21 , , , cord-001397-nrq4ncdf 482 22 which which WDT cord-001397-nrq4ncdf 482 23 may may MD cord-001397-nrq4ncdf 482 24 offer offer VB cord-001397-nrq4ncdf 482 25 protection protection NN cord-001397-nrq4ncdf 482 26 from from IN cord-001397-nrq4ncdf 482 27 recognition recognition NN cord-001397-nrq4ncdf 482 28 by by IN cord-001397-nrq4ncdf 482 29 pathogen pathogen NN cord-001397-nrq4ncdf 482 30 recognition recognition NN cord-001397-nrq4ncdf 482 31 receptors receptor NNS cord-001397-nrq4ncdf 482 32 , , , cord-001397-nrq4ncdf 482 33 thus thus RB cord-001397-nrq4ncdf 482 34 delaying delay VBG cord-001397-nrq4ncdf 482 35 IFN IFN NNP cord-001397-nrq4ncdf 482 36 production production NN cord-001397-nrq4ncdf 482 37 ( ( -LRB- cord-001397-nrq4ncdf 482 38 Welsch Welsch NNP cord-001397-nrq4ncdf 482 39 et et NNP cord-001397-nrq4ncdf 482 40 al al NNP cord-001397-nrq4ncdf 482 41 . . NNP cord-001397-nrq4ncdf 482 42 , , , cord-001397-nrq4ncdf 482 43 2009 2009 CD cord-001397-nrq4ncdf 482 44 ; ; : cord-001397-nrq4ncdf 482 45 Gillespie Gillespie NNP cord-001397-nrq4ncdf 482 46 et et NNP cord-001397-nrq4ncdf 482 47 al al NNP cord-001397-nrq4ncdf 482 48 . . NNP cord-001397-nrq4ncdf 482 49 , , , cord-001397-nrq4ncdf 482 50 2010 2010 CD cord-001397-nrq4ncdf 482 51 ; ; : cord-001397-nrq4ncdf 482 52 Overby Overby NNP cord-001397-nrq4ncdf 482 53 et et NNP cord-001397-nrq4ncdf 482 54 al al NNP cord-001397-nrq4ncdf 482 55 . . NNP cord-001397-nrq4ncdf 482 56 , , , cord-001397-nrq4ncdf 482 57 2010 2010 CD cord-001397-nrq4ncdf 482 58 ; ; : cord-001397-nrq4ncdf 482 59 Offerdahl Offerdahl NNP cord-001397-nrq4ncdf 482 60 et et NNP cord-001397-nrq4ncdf 482 61 al al NNP cord-001397-nrq4ncdf 482 62 . . NNP cord-001397-nrq4ncdf 482 63 , , , cord-001397-nrq4ncdf 482 64 2012 2012 CD cord-001397-nrq4ncdf 482 65 ; ; : cord-001397-nrq4ncdf 482 66 Ye Ye NNP cord-001397-nrq4ncdf 482 67 et et NNP cord-001397-nrq4ncdf 482 68 al al NNP cord-001397-nrq4ncdf 482 69 . . NNP cord-001397-nrq4ncdf 482 70 , , , cord-001397-nrq4ncdf 482 71 2013 2013 CD cord-001397-nrq4ncdf 482 72 ) ) -RRB- cord-001397-nrq4ncdf 482 73 . . . cord-001397-nrq4ncdf 483 1 In in IN cord-001397-nrq4ncdf 483 2 addition addition NN cord-001397-nrq4ncdf 483 3 , , , cord-001397-nrq4ncdf 483 4 some some DT cord-001397-nrq4ncdf 483 5 VBFVs vbfv NNS cord-001397-nrq4ncdf 483 6 can can MD cord-001397-nrq4ncdf 483 7 directly directly RB cord-001397-nrq4ncdf 483 8 affect affect VB cord-001397-nrq4ncdf 483 9 IFN IFN NNP cord-001397-nrq4ncdf 483 10 secretion secretion NN cord-001397-nrq4ncdf 483 11 by by IN cord-001397-nrq4ncdf 483 12 inhibiting inhibit VBG cord-001397-nrq4ncdf 483 13 IFN IFN NNP cord-001397-nrq4ncdf 483 14 gene gene NN cord-001397-nrq4ncdf 483 15 transcription transcription NN cord-001397-nrq4ncdf 483 16 , , , cord-001397-nrq4ncdf 483 17 suppressing suppress VBG cord-001397-nrq4ncdf 483 18 IFN IFN NNP cord-001397-nrq4ncdf 483 19 signaling signal VBG cord-001397-nrq4ncdf 483 20 or or CC cord-001397-nrq4ncdf 483 21 impairing impair VBG cord-001397-nrq4ncdf 483 22 the the DT cord-001397-nrq4ncdf 483 23 functions function NNS cord-001397-nrq4ncdf 483 24 of of IN cord-001397-nrq4ncdf 483 25 interferon interferon NN cord-001397-nrq4ncdf 483 26 - - HYPH cord-001397-nrq4ncdf 483 27 stimulated stimulate VBN cord-001397-nrq4ncdf 483 28 genes gene NNS cord-001397-nrq4ncdf 483 29 ( ( -LRB- cord-001397-nrq4ncdf 483 30 Best best RB cord-001397-nrq4ncdf 483 31 et et FW cord-001397-nrq4ncdf 483 32 al al NNP cord-001397-nrq4ncdf 483 33 . . NNP cord-001397-nrq4ncdf 483 34 , , , cord-001397-nrq4ncdf 483 35 2005 2005 CD cord-001397-nrq4ncdf 483 36 ; ; : cord-001397-nrq4ncdf 483 37 Robertson Robertson NNP cord-001397-nrq4ncdf 483 38 et et NNP cord-001397-nrq4ncdf 483 39 al al NNP cord-001397-nrq4ncdf 483 40 . . NNP cord-001397-nrq4ncdf 483 41 , , , cord-001397-nrq4ncdf 483 42 2009 2009 CD cord-001397-nrq4ncdf 483 43 ; ; . cord-001397-nrq4ncdf 484 1 Ye Ye NNP cord-001397-nrq4ncdf 484 2 et et NNP cord-001397-nrq4ncdf 484 3 al al NNP cord-001397-nrq4ncdf 484 4 . . NNP cord-001397-nrq4ncdf 484 5 , , , cord-001397-nrq4ncdf 484 6 2013 2013 CD cord-001397-nrq4ncdf 484 7 ) ) -RRB- cord-001397-nrq4ncdf 484 8 . . . cord-001397-nrq4ncdf 485 1 The the DT cord-001397-nrq4ncdf 485 2 humoral humoral JJ cord-001397-nrq4ncdf 485 3 and and CC cord-001397-nrq4ncdf 485 4 cell cell NN cord-001397-nrq4ncdf 485 5 - - HYPH cord-001397-nrq4ncdf 485 6 mediated mediate VBN cord-001397-nrq4ncdf 485 7 immune immune JJ cord-001397-nrq4ncdf 485 8 responses response NNS cord-001397-nrq4ncdf 485 9 are be VBP cord-001397-nrq4ncdf 485 10 also also RB cord-001397-nrq4ncdf 485 11 prone prone JJ cord-001397-nrq4ncdf 485 12 to to IN cord-001397-nrq4ncdf 485 13 inhibition inhibition NN cord-001397-nrq4ncdf 485 14 by by IN cord-001397-nrq4ncdf 485 15 VBFVs vbfv NNS cord-001397-nrq4ncdf 485 16 . . . cord-001397-nrq4ncdf 486 1 Studies study NNS cord-001397-nrq4ncdf 486 2 with with IN cord-001397-nrq4ncdf 486 3 WNV WNV NNP cord-001397-nrq4ncdf 486 4 in in IN cord-001397-nrq4ncdf 486 5 C57BL/6 C57BL/6 NNP cord-001397-nrq4ncdf 486 6 mice mouse NNS cord-001397-nrq4ncdf 486 7 suggest suggest VBP cord-001397-nrq4ncdf 486 8 that that IN cord-001397-nrq4ncdf 486 9 WNV WNV NNP cord-001397-nrq4ncdf 486 10 - - HYPH cord-001397-nrq4ncdf 486 11 specific specific JJ cord-001397-nrq4ncdf 486 12 antibodies antibody NNS cord-001397-nrq4ncdf 486 13 correlate correlate VBP cord-001397-nrq4ncdf 486 14 with with IN cord-001397-nrq4ncdf 486 15 decreased decrease VBN cord-001397-nrq4ncdf 486 16 spread spread NN cord-001397-nrq4ncdf 486 17 to to IN cord-001397-nrq4ncdf 486 18 the the DT cord-001397-nrq4ncdf 486 19 CNS CNS NNP cord-001397-nrq4ncdf 486 20 ( ( -LRB- cord-001397-nrq4ncdf 486 21 Diamond Diamond NNP cord-001397-nrq4ncdf 486 22 , , , cord-001397-nrq4ncdf 486 23 2003 2003 CD cord-001397-nrq4ncdf 486 24 ) ) -RRB- cord-001397-nrq4ncdf 486 25 . . . cord-001397-nrq4ncdf 487 1 Antibody antibody NN cord-001397-nrq4ncdf 487 2 escape escape NN cord-001397-nrq4ncdf 487 3 mutants mutant NNS cord-001397-nrq4ncdf 487 4 could could MD cord-001397-nrq4ncdf 487 5 also also RB cord-001397-nrq4ncdf 487 6 evade evade VB cord-001397-nrq4ncdf 487 7 the the DT cord-001397-nrq4ncdf 487 8 T T NNP cord-001397-nrq4ncdf 487 9 cell cell NN cord-001397-nrq4ncdf 487 10 recognition recognition NN cord-001397-nrq4ncdf 487 11 ( ( -LRB- cord-001397-nrq4ncdf 487 12 Diamond Diamond NNP cord-001397-nrq4ncdf 487 13 , , , cord-001397-nrq4ncdf 487 14 2003 2003 CD cord-001397-nrq4ncdf 487 15 ) ) -RRB- cord-001397-nrq4ncdf 487 16 , , , cord-001397-nrq4ncdf 487 17 but but CC cord-001397-nrq4ncdf 487 18 a a DT cord-001397-nrq4ncdf 487 19 precise precise JJ cord-001397-nrq4ncdf 487 20 role role NN cord-001397-nrq4ncdf 487 21 of of IN cord-001397-nrq4ncdf 487 22 these these DT cord-001397-nrq4ncdf 487 23 in in IN cord-001397-nrq4ncdf 487 24 viral viral JJ cord-001397-nrq4ncdf 487 25 persistence persistence NN cord-001397-nrq4ncdf 487 26 is be VBZ cord-001397-nrq4ncdf 487 27 yet yet RB cord-001397-nrq4ncdf 487 28 to to TO cord-001397-nrq4ncdf 487 29 be be VB cord-001397-nrq4ncdf 487 30 defined define VBN cord-001397-nrq4ncdf 487 31 . . . cord-001397-nrq4ncdf 488 1 The the DT cord-001397-nrq4ncdf 488 2 E e NN cord-001397-nrq4ncdf 488 3 protein protein NN cord-001397-nrq4ncdf 488 4 is be VBZ cord-001397-nrq4ncdf 488 5 thought think VBN cord-001397-nrq4ncdf 488 6 to to TO cord-001397-nrq4ncdf 488 7 be be VB cord-001397-nrq4ncdf 488 8 responsible responsible JJ cord-001397-nrq4ncdf 488 9 for for IN cord-001397-nrq4ncdf 488 10 provoking provoke VBG cord-001397-nrq4ncdf 488 11 the the DT cord-001397-nrq4ncdf 488 12 cytopathic cytopathic JJ cord-001397-nrq4ncdf 488 13 effect effect NN cord-001397-nrq4ncdf 488 14 ( ( -LRB- cord-001397-nrq4ncdf 488 15 Isaeva Isaeva NNP cord-001397-nrq4ncdf 488 16 et et FW cord-001397-nrq4ncdf 488 17 al al NNP cord-001397-nrq4ncdf 488 18 . . . cord-001397-nrq4ncdf 489 1 , , , cord-001397-nrq4ncdf 489 2 1998 1998 CD cord-001397-nrq4ncdf 489 3 ; ; : cord-001397-nrq4ncdf 489 4 Prikhod'ko Prikhod'ko NNP cord-001397-nrq4ncdf 489 5 et et NNP cord-001397-nrq4ncdf 489 6 al al NNP cord-001397-nrq4ncdf 489 7 . . NNP cord-001397-nrq4ncdf 489 8 , , , cord-001397-nrq4ncdf 489 9 2001 2001 CD cord-001397-nrq4ncdf 489 10 ) ) -RRB- cord-001397-nrq4ncdf 489 11 . . . cord-001397-nrq4ncdf 490 1 However however RB cord-001397-nrq4ncdf 490 2 , , , cord-001397-nrq4ncdf 490 3 the the DT cord-001397-nrq4ncdf 490 4 NS3 ns3 RB cord-001397-nrq4ncdf 490 5 protease protease NN cord-001397-nrq4ncdf 490 6 and and CC cord-001397-nrq4ncdf 490 7 NS2B NS2B NNP cord-001397-nrq4ncdf 490 8 - - : cord-001397-nrq4ncdf 490 9 NS3 ns3 RB cord-001397-nrq4ncdf 490 10 protease protease NN cord-001397-nrq4ncdf 490 11 precursor precursor NN cord-001397-nrq4ncdf 490 12 ( ( -LRB- cord-001397-nrq4ncdf 490 13 Table table NN cord-001397-nrq4ncdf 490 14 1 1 CD cord-001397-nrq4ncdf 490 15 ) ) -RRB- cord-001397-nrq4ncdf 490 16 are be VBP cord-001397-nrq4ncdf 490 17 also also RB cord-001397-nrq4ncdf 490 18 known know VBN cord-001397-nrq4ncdf 490 19 to to TO cord-001397-nrq4ncdf 490 20 induce induce VB cord-001397-nrq4ncdf 490 21 apoptosis apoptosis NN cord-001397-nrq4ncdf 490 22 by by IN cord-001397-nrq4ncdf 490 23 binding bind VBG cord-001397-nrq4ncdf 490 24 to to IN cord-001397-nrq4ncdf 490 25 caspase caspase NN cord-001397-nrq4ncdf 490 26 8 8 CD cord-001397-nrq4ncdf 490 27 ( ( -LRB- cord-001397-nrq4ncdf 490 28 Shafee Shafee NNP cord-001397-nrq4ncdf 490 29 & & CC cord-001397-nrq4ncdf 490 30 AbuBakar AbuBakar NNP cord-001397-nrq4ncdf 490 31 , , , cord-001397-nrq4ncdf 490 32 2003 2003 CD cord-001397-nrq4ncdf 490 33 ; ; : cord-001397-nrq4ncdf 490 34 Ramanathan Ramanathan NNP cord-001397-nrq4ncdf 490 35 et et NNP cord-001397-nrq4ncdf 490 36 al al NNP cord-001397-nrq4ncdf 490 37 . . NNP cord-001397-nrq4ncdf 490 38 , , , cord-001397-nrq4ncdf 490 39 2006 2006 CD cord-001397-nrq4ncdf 490 40 ; ; . cord-001397-nrq4ncdf 491 1 Safronetz Safronetz NNP cord-001397-nrq4ncdf 491 2 et et NNP cord-001397-nrq4ncdf 491 3 al al NNP cord-001397-nrq4ncdf 491 4 . . NNP cord-001397-nrq4ncdf 491 5 , , , cord-001397-nrq4ncdf 491 6 2013 2013 CD cord-001397-nrq4ncdf 491 7 ) ) -RRB- cord-001397-nrq4ncdf 491 8 . . . cord-001397-nrq4ncdf 492 1 In in IN cord-001397-nrq4ncdf 492 2 addition addition NN cord-001397-nrq4ncdf 492 3 , , , cord-001397-nrq4ncdf 492 4 NS2A NS2A NNP cord-001397-nrq4ncdf 492 5 has have VBZ cord-001397-nrq4ncdf 492 6 also also RB cord-001397-nrq4ncdf 492 7 been be VBN cord-001397-nrq4ncdf 492 8 implicated implicate VBN cord-001397-nrq4ncdf 492 9 in in IN cord-001397-nrq4ncdf 492 10 causing cause VBG cord-001397-nrq4ncdf 492 11 IFN IFN NNP cord-001397-nrq4ncdf 492 12 - - HYPH cord-001397-nrq4ncdf 492 13 independent independent JJ cord-001397-nrq4ncdf 492 14 cytopathic cytopathic JJ cord-001397-nrq4ncdf 492 15 effect effect NN cord-001397-nrq4ncdf 493 1 ( ( -LRB- cord-001397-nrq4ncdf 493 2 Chang Chang NNP cord-001397-nrq4ncdf 493 3 et et NNP cord-001397-nrq4ncdf 493 4 al al NNP cord-001397-nrq4ncdf 493 5 . . NNP cord-001397-nrq4ncdf 493 6 , , , cord-001397-nrq4ncdf 493 7 1999 1999 CD cord-001397-nrq4ncdf 493 8 ; ; : cord-001397-nrq4ncdf 493 9 Melian Melian NNP cord-001397-nrq4ncdf 493 10 et et FW cord-001397-nrq4ncdf 493 11 al al NNP cord-001397-nrq4ncdf 493 12 . . NNP cord-001397-nrq4ncdf 493 13 , , , cord-001397-nrq4ncdf 493 14 2013 2013 CD cord-001397-nrq4ncdf 493 15 ) ) -RRB- cord-001397-nrq4ncdf 493 16 . . . cord-001397-nrq4ncdf 494 1 Observations observation NNS cord-001397-nrq4ncdf 494 2 in in IN cord-001397-nrq4ncdf 494 3 our -PRON- PRP$ cord-001397-nrq4ncdf 494 4 laboratory laboratory NN cord-001397-nrq4ncdf 494 5 ( ( -LRB- cord-001397-nrq4ncdf 494 6 L. L. NNP cord-001397-nrq4ncdf 494 7 Mlera Mlera NNP cord-001397-nrq4ncdf 494 8 , , , cord-001397-nrq4ncdf 494 9 D. D. NNP cord-001397-nrq4ncdf 494 10 Offerdahl Offerdahl NNP cord-001397-nrq4ncdf 494 11 & & CC cord-001397-nrq4ncdf 494 12 M.E. M.E. NNP cord-001397-nrq4ncdf 494 13 Bloom Bloom NNP cord-001397-nrq4ncdf 494 14 , , , cord-001397-nrq4ncdf 494 15 unpublished unpublished JJ cord-001397-nrq4ncdf 494 16 results result NNS cord-001397-nrq4ncdf 494 17 ) ) -RRB- cord-001397-nrq4ncdf 494 18 and and CC cord-001397-nrq4ncdf 494 19 those those DT cord-001397-nrq4ncdf 494 20 of of IN cord-001397-nrq4ncdf 494 21 others other NNS cord-001397-nrq4ncdf 494 22 ( ( -LRB- cord-001397-nrq4ncdf 494 23 Lancaster Lancaster NNP cord-001397-nrq4ncdf 494 24 et et NNP cord-001397-nrq4ncdf 494 25 al al NNP cord-001397-nrq4ncdf 494 26 . . NNP cord-001397-nrq4ncdf 494 27 , , , cord-001397-nrq4ncdf 494 28 1998 1998 CD cord-001397-nrq4ncdf 494 29 ) ) -RRB- cord-001397-nrq4ncdf 494 30 indicate indicate VBP cord-001397-nrq4ncdf 494 31 that that IN cord-001397-nrq4ncdf 494 32 TBFV tbfv NN cord-001397-nrq4ncdf 494 33 infection infection NN cord-001397-nrq4ncdf 494 34 in in IN cord-001397-nrq4ncdf 494 35 mammalian mammalian JJ cord-001397-nrq4ncdf 494 36 cell cell NN cord-001397-nrq4ncdf 494 37 culture culture NN cord-001397-nrq4ncdf 494 38 is be VBZ cord-001397-nrq4ncdf 494 39 characterized characterize VBN cord-001397-nrq4ncdf 494 40 by by IN cord-001397-nrq4ncdf 494 41 an an DT cord-001397-nrq4ncdf 494 42 acute acute JJ cord-001397-nrq4ncdf 494 43 phase phase NN cord-001397-nrq4ncdf 494 44 , , , cord-001397-nrq4ncdf 494 45 which which WDT cord-001397-nrq4ncdf 494 46 kills kill VBZ cord-001397-nrq4ncdf 494 47 most most RBS cord-001397-nrq4ncdf 494 48 infected infected JJ cord-001397-nrq4ncdf 494 49 cells cell NNS cord-001397-nrq4ncdf 494 50 ; ; : cord-001397-nrq4ncdf 494 51 however however RB cord-001397-nrq4ncdf 494 52 , , , cord-001397-nrq4ncdf 494 53 a a DT cord-001397-nrq4ncdf 494 54 small small JJ cord-001397-nrq4ncdf 494 55 number number NN cord-001397-nrq4ncdf 494 56 of of IN cord-001397-nrq4ncdf 494 57 cells cell NNS cord-001397-nrq4ncdf 494 58 survive survive VBP cord-001397-nrq4ncdf 494 59 the the DT cord-001397-nrq4ncdf 494 60 initial initial JJ cord-001397-nrq4ncdf 494 61 cytolytic cytolytic JJ cord-001397-nrq4ncdf 494 62 phase phase NN cord-001397-nrq4ncdf 494 63 , , , cord-001397-nrq4ncdf 494 64 and and CC cord-001397-nrq4ncdf 494 65 the the DT cord-001397-nrq4ncdf 494 66 culture culture NN cord-001397-nrq4ncdf 494 67 is be VBZ cord-001397-nrq4ncdf 494 68 repopulated repopulate VBN cord-001397-nrq4ncdf 494 69 with with IN cord-001397-nrq4ncdf 494 70 cells cell NNS cord-001397-nrq4ncdf 494 71 almost almost RB cord-001397-nrq4ncdf 494 72 all all DT cord-001397-nrq4ncdf 494 73 of of IN cord-001397-nrq4ncdf 494 74 which which WDT cord-001397-nrq4ncdf 494 75 are be VBP cord-001397-nrq4ncdf 494 76 infected infect VBN cord-001397-nrq4ncdf 494 77 . . . cord-001397-nrq4ncdf 495 1 Clearly clearly RB cord-001397-nrq4ncdf 495 2 , , , cord-001397-nrq4ncdf 495 3 VBFV VBFV NNP cord-001397-nrq4ncdf 495 4 induces induce VBZ cord-001397-nrq4ncdf 495 5 an an DT cord-001397-nrq4ncdf 495 6 acutely acutely RB cord-001397-nrq4ncdf 495 7 cytopathic cytopathic JJ cord-001397-nrq4ncdf 495 8 infection infection NN cord-001397-nrq4ncdf 495 9 in in IN cord-001397-nrq4ncdf 495 10 mammalian mammalian JJ cord-001397-nrq4ncdf 495 11 cells cell NNS cord-001397-nrq4ncdf 495 12 , , , cord-001397-nrq4ncdf 495 13 and and CC cord-001397-nrq4ncdf 495 14 thus thus RB cord-001397-nrq4ncdf 495 15 , , , cord-001397-nrq4ncdf 495 16 the the DT cord-001397-nrq4ncdf 495 17 development development NN cord-001397-nrq4ncdf 495 18 of of IN cord-001397-nrq4ncdf 495 19 a a DT cord-001397-nrq4ncdf 495 20 persistent persistent JJ cord-001397-nrq4ncdf 495 21 infection infection NN cord-001397-nrq4ncdf 495 22 implies imply VBZ cord-001397-nrq4ncdf 495 23 that that IN cord-001397-nrq4ncdf 495 24 cell cell NN cord-001397-nrq4ncdf 495 25 death death NN cord-001397-nrq4ncdf 495 26 factors factor NNS cord-001397-nrq4ncdf 495 27 must must MD cord-001397-nrq4ncdf 495 28 be be VB cord-001397-nrq4ncdf 495 29 evaded evade VBN cord-001397-nrq4ncdf 495 30 or or CC cord-001397-nrq4ncdf 495 31 modulated modulate VBN cord-001397-nrq4ncdf 495 32 , , , cord-001397-nrq4ncdf 495 33 although although IN cord-001397-nrq4ncdf 495 34 the the DT cord-001397-nrq4ncdf 495 35 precise precise JJ cord-001397-nrq4ncdf 495 36 mechanisms mechanism NNS cord-001397-nrq4ncdf 495 37 are be VBP cord-001397-nrq4ncdf 495 38 still still RB cord-001397-nrq4ncdf 495 39 obscure obscure JJ cord-001397-nrq4ncdf 495 40 . . . cord-001397-nrq4ncdf 496 1 The the DT cord-001397-nrq4ncdf 496 2 implication implication NN cord-001397-nrq4ncdf 496 3 of of IN cord-001397-nrq4ncdf 496 4 specific specific JJ cord-001397-nrq4ncdf 496 5 viral viral JJ cord-001397-nrq4ncdf 496 6 proteins protein NNS cord-001397-nrq4ncdf 496 7 , , , cord-001397-nrq4ncdf 496 8 domains domain NNS cord-001397-nrq4ncdf 496 9 , , , cord-001397-nrq4ncdf 496 10 or or CC cord-001397-nrq4ncdf 496 11 sequences sequence NNS cord-001397-nrq4ncdf 496 12 that that WDT cord-001397-nrq4ncdf 496 13 combat combat VBP cord-001397-nrq4ncdf 496 14 cytolytic cytolytic JJ cord-001397-nrq4ncdf 496 15 cell cell NN cord-001397-nrq4ncdf 496 16 death death NN cord-001397-nrq4ncdf 496 17 has have VBZ cord-001397-nrq4ncdf 496 18 been be VBN cord-001397-nrq4ncdf 496 19 rather rather RB cord-001397-nrq4ncdf 496 20 limited limited JJ cord-001397-nrq4ncdf 496 21 , , , cord-001397-nrq4ncdf 496 22 but but CC cord-001397-nrq4ncdf 496 23 any any DT cord-001397-nrq4ncdf 496 24 viral viral JJ cord-001397-nrq4ncdf 496 25 determinants determinant NNS cord-001397-nrq4ncdf 496 26 that that WDT cord-001397-nrq4ncdf 496 27 limit limit VBP cord-001397-nrq4ncdf 496 28 cell cell NN cord-001397-nrq4ncdf 496 29 death death NN cord-001397-nrq4ncdf 496 30 in in IN cord-001397-nrq4ncdf 496 31 the the DT cord-001397-nrq4ncdf 496 32 face face NN cord-001397-nrq4ncdf 496 33 of of IN cord-001397-nrq4ncdf 496 34 acute acute JJ cord-001397-nrq4ncdf 496 35 infection infection NN cord-001397-nrq4ncdf 496 36 might may MD cord-001397-nrq4ncdf 496 37 also also RB cord-001397-nrq4ncdf 496 38 enhance enhance VB cord-001397-nrq4ncdf 496 39 the the DT cord-001397-nrq4ncdf 496 40 initiation initiation NN cord-001397-nrq4ncdf 496 41 of of IN cord-001397-nrq4ncdf 496 42 persistent persistent JJ cord-001397-nrq4ncdf 496 43 infection infection NN cord-001397-nrq4ncdf 496 44 . . . cord-001397-nrq4ncdf 497 1 For for IN cord-001397-nrq4ncdf 497 2 example example NN cord-001397-nrq4ncdf 497 3 , , , cord-001397-nrq4ncdf 497 4 viral viral JJ cord-001397-nrq4ncdf 497 5 NS4A ns4a NN cord-001397-nrq4ncdf 497 6 ( ( -LRB- cord-001397-nrq4ncdf 497 7 Table table NN cord-001397-nrq4ncdf 497 8 1 1 CD cord-001397-nrq4ncdf 497 9 ) ) -RRB- cord-001397-nrq4ncdf 497 10 was be VBD cord-001397-nrq4ncdf 497 11 shown show VBN cord-001397-nrq4ncdf 497 12 to to TO cord-001397-nrq4ncdf 497 13 induce induce VB cord-001397-nrq4ncdf 497 14 phosphatidylinositol phosphatidylinositol NN cord-001397-nrq4ncdf 497 15 3-kinase 3-kinase CD cord-001397-nrq4ncdf 497 16 ( ( -LRB- cord-001397-nrq4ncdf 497 17 PI3K)-dependent pi3k)-dependent JJ cord-001397-nrq4ncdf 497 18 autophagy autophagy NN cord-001397-nrq4ncdf 497 19 and and CC cord-001397-nrq4ncdf 497 20 thereby thereby RB cord-001397-nrq4ncdf 497 21 leading lead VBG cord-001397-nrq4ncdf 497 22 to to IN cord-001397-nrq4ncdf 497 23 protection protection NN cord-001397-nrq4ncdf 497 24 from from IN cord-001397-nrq4ncdf 497 25 cell cell NN cord-001397-nrq4ncdf 497 26 death death NN cord-001397-nrq4ncdf 498 1 ( ( -LRB- cord-001397-nrq4ncdf 498 2 McLean McLean NNP cord-001397-nrq4ncdf 498 3 et et NNP cord-001397-nrq4ncdf 498 4 al al NNP cord-001397-nrq4ncdf 498 5 . . NNP cord-001397-nrq4ncdf 498 6 , , , cord-001397-nrq4ncdf 498 7 2011 2011 CD cord-001397-nrq4ncdf 498 8 ) ) -RRB- cord-001397-nrq4ncdf 498 9 . . . cord-001397-nrq4ncdf 499 1 The the DT cord-001397-nrq4ncdf 499 2 manipulation manipulation NN cord-001397-nrq4ncdf 499 3 of of IN cord-001397-nrq4ncdf 499 4 apoptosis apoptosis NN cord-001397-nrq4ncdf 499 5 by by IN cord-001397-nrq4ncdf 499 6 JEV JEV NNP cord-001397-nrq4ncdf 499 7 , , , cord-001397-nrq4ncdf 499 8 which which WDT cord-001397-nrq4ncdf 499 9 activates activate VBZ cord-001397-nrq4ncdf 499 10 PI3 PI3 NNP cord-001397-nrq4ncdf 499 11 K K NNP cord-001397-nrq4ncdf 499 12 in in IN cord-001397-nrq4ncdf 499 13 infected infected JJ cord-001397-nrq4ncdf 499 14 cells cell NNS cord-001397-nrq4ncdf 499 15 , , , cord-001397-nrq4ncdf 499 16 was be VBD cord-001397-nrq4ncdf 499 17 also also RB cord-001397-nrq4ncdf 499 18 reported report VBN cord-001397-nrq4ncdf 499 19 ( ( -LRB- cord-001397-nrq4ncdf 499 20 Lee Lee NNP cord-001397-nrq4ncdf 499 21 et et NNP cord-001397-nrq4ncdf 499 22 al al NNP cord-001397-nrq4ncdf 499 23 . . NNP cord-001397-nrq4ncdf 499 24 , , , cord-001397-nrq4ncdf 499 25 2005 2005 CD cord-001397-nrq4ncdf 499 26 ) ) -RRB- cord-001397-nrq4ncdf 499 27 . . . cord-001397-nrq4ncdf 500 1 JEV JEV NNP cord-001397-nrq4ncdf 500 2 triggers trigger VBZ cord-001397-nrq4ncdf 500 3 apoptosis apoptosi NNS cord-001397-nrq4ncdf 500 4 during during IN cord-001397-nrq4ncdf 500 5 the the DT cord-001397-nrq4ncdf 500 6 late late JJ cord-001397-nrq4ncdf 500 7 stages stage NNS cord-001397-nrq4ncdf 500 8 of of IN cord-001397-nrq4ncdf 500 9 infection infection NN cord-001397-nrq4ncdf 500 10 , , , cord-001397-nrq4ncdf 500 11 and and CC cord-001397-nrq4ncdf 500 12 the the DT cord-001397-nrq4ncdf 500 13 activation activation NN cord-001397-nrq4ncdf 500 14 of of IN cord-001397-nrq4ncdf 500 15 PI3 PI3 NNP cord-001397-nrq4ncdf 500 16 K K NNP cord-001397-nrq4ncdf 500 17 is be VBZ cord-001397-nrq4ncdf 500 18 thought think VBN cord-001397-nrq4ncdf 500 19 to to TO cord-001397-nrq4ncdf 500 20 provide provide VB cord-001397-nrq4ncdf 500 21 protection protection NN cord-001397-nrq4ncdf 500 22 from from IN cord-001397-nrq4ncdf 500 23 early early JJ cord-001397-nrq4ncdf 500 24 cell cell NN cord-001397-nrq4ncdf 500 25 death death NN cord-001397-nrq4ncdf 500 26 . . . cord-001397-nrq4ncdf 501 1 Limited limited JJ cord-001397-nrq4ncdf 501 2 replication replication NN cord-001397-nrq4ncdf 501 3 implies imply VBZ cord-001397-nrq4ncdf 501 4 a a DT cord-001397-nrq4ncdf 501 5 low low JJ cord-001397-nrq4ncdf 501 6 level level NN cord-001397-nrq4ncdf 501 7 of of IN cord-001397-nrq4ncdf 501 8 viral viral JJ cord-001397-nrq4ncdf 501 9 protein protein NN cord-001397-nrq4ncdf 501 10 expression expression NN cord-001397-nrq4ncdf 501 11 and and CC cord-001397-nrq4ncdf 501 12 may may MD cord-001397-nrq4ncdf 501 13 favor favor VB cord-001397-nrq4ncdf 501 14 viral viral JJ cord-001397-nrq4ncdf 501 15 persistence persistence NN cord-001397-nrq4ncdf 501 16 . . . cord-001397-nrq4ncdf 502 1 Over over IN cord-001397-nrq4ncdf 502 2 the the DT cord-001397-nrq4ncdf 502 3 years year NNS cord-001397-nrq4ncdf 502 4 , , , cord-001397-nrq4ncdf 502 5 significant significant JJ cord-001397-nrq4ncdf 502 6 attention attention NN cord-001397-nrq4ncdf 502 7 has have VBZ cord-001397-nrq4ncdf 502 8 been be VBN cord-001397-nrq4ncdf 502 9 focused focus VBN cord-001397-nrq4ncdf 502 10 on on IN cord-001397-nrq4ncdf 502 11 defective defective JJ cord-001397-nrq4ncdf 502 12 interfering interfere VBG cord-001397-nrq4ncdf 502 13 ( ( -LRB- cord-001397-nrq4ncdf 502 14 DI DI NNP cord-001397-nrq4ncdf 502 15 ) ) -RRB- cord-001397-nrq4ncdf 502 16 virus virus NN cord-001397-nrq4ncdf 502 17 particles particle NNS cord-001397-nrq4ncdf 502 18 , , , cord-001397-nrq4ncdf 502 19 which which WDT cord-001397-nrq4ncdf 502 20 limit limit VBP cord-001397-nrq4ncdf 502 21 replication replication NN cord-001397-nrq4ncdf 502 22 of of IN cord-001397-nrq4ncdf 502 23 the the DT cord-001397-nrq4ncdf 502 24 wild wild JJ cord-001397-nrq4ncdf 502 25 - - HYPH cord-001397-nrq4ncdf 502 26 type type NN cord-001397-nrq4ncdf 502 27 virus virus NN cord-001397-nrq4ncdf 502 28 ( ( -LRB- cord-001397-nrq4ncdf 502 29 Schmaljohn Schmaljohn NNP cord-001397-nrq4ncdf 502 30 & & CC cord-001397-nrq4ncdf 502 31 Blair Blair NNP cord-001397-nrq4ncdf 502 32 , , , cord-001397-nrq4ncdf 502 33 1977 1977 CD cord-001397-nrq4ncdf 502 34 ; ; : cord-001397-nrq4ncdf 502 35 Debnath Debnath NNP cord-001397-nrq4ncdf 502 36 et et NNP cord-001397-nrq4ncdf 502 37 al al NNP cord-001397-nrq4ncdf 502 38 . . NNP cord-001397-nrq4ncdf 502 39 , , , cord-001397-nrq4ncdf 502 40 1991 1991 CD cord-001397-nrq4ncdf 502 41 ; ; : cord-001397-nrq4ncdf 502 42 Blitvich Blitvich NNP cord-001397-nrq4ncdf 502 43 et et NNP cord-001397-nrq4ncdf 502 44 al al NNP cord-001397-nrq4ncdf 502 45 . . NNP cord-001397-nrq4ncdf 502 46 , , , cord-001397-nrq4ncdf 502 47 1999 1999 CD cord-001397-nrq4ncdf 502 48 ) ) -RRB- cord-001397-nrq4ncdf 502 49 . . . cord-001397-nrq4ncdf 503 1 The the DT cord-001397-nrq4ncdf 503 2 DI DI NNP cord-001397-nrq4ncdf 503 3 particles particle NNS cord-001397-nrq4ncdf 503 4 represent represent VBP cord-001397-nrq4ncdf 503 5 truncated truncated JJ cord-001397-nrq4ncdf 503 6 genomes genome NNS cord-001397-nrq4ncdf 503 7 that that WDT cord-001397-nrq4ncdf 503 8 can can MD cord-001397-nrq4ncdf 503 9 be be VB cord-001397-nrq4ncdf 503 10 replicated replicate VBN cord-001397-nrq4ncdf 503 11 and and CC cord-001397-nrq4ncdf 503 12 encapsidated encapsidate VBN cord-001397-nrq4ncdf 503 13 and and CC cord-001397-nrq4ncdf 503 14 compete compete VB cord-001397-nrq4ncdf 503 15 with with IN cord-001397-nrq4ncdf 503 16 wild wild JJ cord-001397-nrq4ncdf 503 17 - - HYPH cord-001397-nrq4ncdf 503 18 type type NN cord-001397-nrq4ncdf 503 19 viral viral JJ cord-001397-nrq4ncdf 503 20 particles particle NNS cord-001397-nrq4ncdf 503 21 when when WRB cord-001397-nrq4ncdf 503 22 they -PRON- PRP cord-001397-nrq4ncdf 503 23 infect infect VBP cord-001397-nrq4ncdf 503 24 cells cell NNS cord-001397-nrq4ncdf 503 25 . . . cord-001397-nrq4ncdf 504 1 In in IN cord-001397-nrq4ncdf 504 2 vesicular vesicular JJ cord-001397-nrq4ncdf 504 3 stomatitis stomatitis NN cord-001397-nrq4ncdf 504 4 virus virus NN cord-001397-nrq4ncdf 504 5 ( ( -LRB- cord-001397-nrq4ncdf 504 6 VSV VSV NNP cord-001397-nrq4ncdf 504 7 ) ) -RRB- cord-001397-nrq4ncdf 504 8 , , , cord-001397-nrq4ncdf 504 9 DI DI NNP cord-001397-nrq4ncdf 504 10 particles particle NNS cord-001397-nrq4ncdf 504 11 are be VBP cord-001397-nrq4ncdf 504 12 thought think VBN cord-001397-nrq4ncdf 504 13 to to TO cord-001397-nrq4ncdf 504 14 modulate modulate VB cord-001397-nrq4ncdf 504 15 virulence virulence NN cord-001397-nrq4ncdf 504 16 ( ( -LRB- cord-001397-nrq4ncdf 504 17 Cave Cave NNP cord-001397-nrq4ncdf 504 18 et et NNP cord-001397-nrq4ncdf 504 19 al al NNP cord-001397-nrq4ncdf 504 20 . . NNP cord-001397-nrq4ncdf 504 21 , , , cord-001397-nrq4ncdf 504 22 1985 1985 CD cord-001397-nrq4ncdf 504 23 ) ) -RRB- cord-001397-nrq4ncdf 504 24 . . . cord-001397-nrq4ncdf 505 1 However however RB cord-001397-nrq4ncdf 505 2 , , , cord-001397-nrq4ncdf 505 3 the the DT cord-001397-nrq4ncdf 505 4 role role NN cord-001397-nrq4ncdf 505 5 of of IN cord-001397-nrq4ncdf 505 6 VBFV VBFV NNP cord-001397-nrq4ncdf 505 7 DI DI NNP cord-001397-nrq4ncdf 505 8 particles particle NNS cord-001397-nrq4ncdf 505 9 in in IN cord-001397-nrq4ncdf 505 10 persistence persistence NN cord-001397-nrq4ncdf 505 11 is be VBZ cord-001397-nrq4ncdf 505 12 not not RB cord-001397-nrq4ncdf 505 13 completely completely RB cord-001397-nrq4ncdf 505 14 certain certain JJ cord-001397-nrq4ncdf 505 15 . . . cord-001397-nrq4ncdf 506 1 For for IN cord-001397-nrq4ncdf 506 2 TBEV TBEV NNP cord-001397-nrq4ncdf 506 3 , , , cord-001397-nrq4ncdf 506 4 the the DT cord-001397-nrq4ncdf 506 5 C C NNP cord-001397-nrq4ncdf 506 6 protein protein NN cord-001397-nrq4ncdf 506 7 is be VBZ cord-001397-nrq4ncdf 506 8 reported report VBN cord-001397-nrq4ncdf 506 9 to to TO cord-001397-nrq4ncdf 506 10 tolerate tolerate VB cord-001397-nrq4ncdf 506 11 internal internal JJ cord-001397-nrq4ncdf 506 12 deletions deletion NNS cord-001397-nrq4ncdf 506 13 ranging range VBG cord-001397-nrq4ncdf 506 14 from from IN cord-001397-nrq4ncdf 506 15 4 4 CD cord-001397-nrq4ncdf 506 16 to to TO cord-001397-nrq4ncdf 506 17 21 21 CD cord-001397-nrq4ncdf 506 18 amino amino JJ cord-001397-nrq4ncdf 506 19 acids acid NNS cord-001397-nrq4ncdf 506 20 , , , cord-001397-nrq4ncdf 506 21 and and CC cord-001397-nrq4ncdf 506 22 the the DT cord-001397-nrq4ncdf 506 23 deletions deletion NNS cord-001397-nrq4ncdf 506 24 seem seem VBP cord-001397-nrq4ncdf 506 25 to to TO cord-001397-nrq4ncdf 506 26 favor favor VB cord-001397-nrq4ncdf 506 27 attenuation attenuation NN cord-001397-nrq4ncdf 506 28 and and CC cord-001397-nrq4ncdf 506 29 immunogenicity immunogenicity NN cord-001397-nrq4ncdf 506 30 ( ( -LRB- cord-001397-nrq4ncdf 506 31 Kofler Kofler NNP cord-001397-nrq4ncdf 506 32 et et NNP cord-001397-nrq4ncdf 506 33 al al NNP cord-001397-nrq4ncdf 506 34 . . NNP cord-001397-nrq4ncdf 506 35 , , , cord-001397-nrq4ncdf 506 36 2002 2002 CD cord-001397-nrq4ncdf 506 37 ) ) -RRB- cord-001397-nrq4ncdf 506 38 . . . cord-001397-nrq4ncdf 507 1 DI DI NNP cord-001397-nrq4ncdf 507 2 particles particle NNS cord-001397-nrq4ncdf 507 3 of of IN cord-001397-nrq4ncdf 507 4 VBFVs vbfv NNS cord-001397-nrq4ncdf 507 5 , , , cord-001397-nrq4ncdf 507 6 such such JJ cord-001397-nrq4ncdf 507 7 as as IN cord-001397-nrq4ncdf 507 8 Murray Murray NNP cord-001397-nrq4ncdf 507 9 valley valley NNP cord-001397-nrq4ncdf 507 10 encephalitis encephalitis RB cord-001397-nrq4ncdf 507 11 ( ( -LRB- cord-001397-nrq4ncdf 507 12 MVE MVE NNP cord-001397-nrq4ncdf 507 13 ) ) -RRB- cord-001397-nrq4ncdf 507 14 , , , cord-001397-nrq4ncdf 507 15 TBEV TBEV NNP cord-001397-nrq4ncdf 507 16 Sofjin Sofjin NNP cord-001397-nrq4ncdf 507 17 strain strain NN cord-001397-nrq4ncdf 507 18 , , , cord-001397-nrq4ncdf 507 19 and and CC cord-001397-nrq4ncdf 507 20 WNV WNV NNP cord-001397-nrq4ncdf 507 21 , , , cord-001397-nrq4ncdf 507 22 are be VBP cord-001397-nrq4ncdf 507 23 known know VBN cord-001397-nrq4ncdf 507 24 to to TO cord-001397-nrq4ncdf 507 25 generate generate VB cord-001397-nrq4ncdf 507 26 truncated truncated JJ cord-001397-nrq4ncdf 507 27 NS1 NS1 NNS cord-001397-nrq4ncdf 507 28 proteins protein NNS cord-001397-nrq4ncdf 507 29 , , , cord-001397-nrq4ncdf 507 30 following follow VBG cord-001397-nrq4ncdf 507 31 infection infection NN cord-001397-nrq4ncdf 507 32 at at IN cord-001397-nrq4ncdf 507 33 high high JJ cord-001397-nrq4ncdf 507 34 multiplicity multiplicity NN cord-001397-nrq4ncdf 507 35 of of IN cord-001397-nrq4ncdf 507 36 infection infection NN cord-001397-nrq4ncdf 508 1 ( ( -LRB- cord-001397-nrq4ncdf 508 2 Debnath Debnath NNP cord-001397-nrq4ncdf 508 3 et et NNP cord-001397-nrq4ncdf 508 4 al al NNP cord-001397-nrq4ncdf 508 5 . . . cord-001397-nrq4ncdf 509 1 , , , cord-001397-nrq4ncdf 509 2 1991 1991 CD cord-001397-nrq4ncdf 509 3 ; ; : cord-001397-nrq4ncdf 509 4 Poidinger Poidinger NNP cord-001397-nrq4ncdf 509 5 et et NNP cord-001397-nrq4ncdf 509 6 al al NNP cord-001397-nrq4ncdf 509 7 . . NNP cord-001397-nrq4ncdf 509 8 , , , cord-001397-nrq4ncdf 509 9 1991 1991 CD cord-001397-nrq4ncdf 510 1 ; ; : cord-001397-nrq4ncdf 510 2 Chen Chen NNP cord-001397-nrq4ncdf 510 3 et et NNP cord-001397-nrq4ncdf 510 4 al al NNP cord-001397-nrq4ncdf 510 5 . . . cord-001397-nrq4ncdf 511 1 , , , cord-001397-nrq4ncdf 511 2 1996 1996 CD cord-001397-nrq4ncdf 511 3 ; ; : cord-001397-nrq4ncdf 511 4 Bugrysheva Bugrysheva NNP cord-001397-nrq4ncdf 511 5 et et NNP cord-001397-nrq4ncdf 511 6 al al NNP cord-001397-nrq4ncdf 511 7 . . NNP cord-001397-nrq4ncdf 511 8 , , , cord-001397-nrq4ncdf 511 9 2001 2001 CD cord-001397-nrq4ncdf 511 10 ) ) -RRB- cord-001397-nrq4ncdf 511 11 . . . cord-001397-nrq4ncdf 512 1 Persistent persistent JJ cord-001397-nrq4ncdf 512 2 infection infection NN cord-001397-nrq4ncdf 512 3 of of IN cord-001397-nrq4ncdf 512 4 Vero Vero NNP cord-001397-nrq4ncdf 512 5 cells cell NNS cord-001397-nrq4ncdf 512 6 with with IN cord-001397-nrq4ncdf 512 7 MVE MVE NNP cord-001397-nrq4ncdf 512 8 was be VBD cord-001397-nrq4ncdf 512 9 associated associate VBN cord-001397-nrq4ncdf 512 10 with with IN cord-001397-nrq4ncdf 512 11 a a DT cord-001397-nrq4ncdf 512 12 truncated truncated JJ cord-001397-nrq4ncdf 512 13 NS1 NS1 NNS cord-001397-nrq4ncdf 512 14 , , , cord-001397-nrq4ncdf 512 15 whereas whereas IN cord-001397-nrq4ncdf 512 16 this this DT cord-001397-nrq4ncdf 512 17 form form NN cord-001397-nrq4ncdf 512 18 of of IN cord-001397-nrq4ncdf 512 19 NS1 ns1 NN cord-001397-nrq4ncdf 512 20 was be VBD cord-001397-nrq4ncdf 512 21 not not RB cord-001397-nrq4ncdf 512 22 noted note VBN cord-001397-nrq4ncdf 512 23 in in IN cord-001397-nrq4ncdf 512 24 the the DT cord-001397-nrq4ncdf 512 25 acute acute JJ cord-001397-nrq4ncdf 512 26 infection infection NN cord-001397-nrq4ncdf 512 27 ( ( -LRB- cord-001397-nrq4ncdf 512 28 Brinton Brinton NNP cord-001397-nrq4ncdf 512 29 , , , cord-001397-nrq4ncdf 512 30 1982 1982 CD cord-001397-nrq4ncdf 512 31 ; ; : cord-001397-nrq4ncdf 512 32 Lancaster Lancaster NNP cord-001397-nrq4ncdf 512 33 et et NNP cord-001397-nrq4ncdf 512 34 al al NNP cord-001397-nrq4ncdf 512 35 . . NNP cord-001397-nrq4ncdf 512 36 , , , cord-001397-nrq4ncdf 512 37 1998 1998 CD cord-001397-nrq4ncdf 512 38 ) ) -RRB- cord-001397-nrq4ncdf 512 39 . . . cord-001397-nrq4ncdf 513 1 The the DT cord-001397-nrq4ncdf 513 2 truncated truncated JJ cord-001397-nrq4ncdf 513 3 NS1 ns1 NN cord-001397-nrq4ncdf 513 4 in in IN cord-001397-nrq4ncdf 513 5 MVE MVE NNP cord-001397-nrq4ncdf 513 6 virus virus NN cord-001397-nrq4ncdf 513 7 was be VBD cord-001397-nrq4ncdf 513 8 a a DT cord-001397-nrq4ncdf 513 9 result result NN cord-001397-nrq4ncdf 513 10 of of IN cord-001397-nrq4ncdf 513 11 the the DT cord-001397-nrq4ncdf 513 12 presence presence NN cord-001397-nrq4ncdf 513 13 of of IN cord-001397-nrq4ncdf 513 14 DI DI NNP cord-001397-nrq4ncdf 513 15 RNA RNA NNP cord-001397-nrq4ncdf 513 16 , , , cord-001397-nrq4ncdf 513 17 which which WDT cord-001397-nrq4ncdf 513 18 contained contain VBD cord-001397-nrq4ncdf 513 19 a a DT cord-001397-nrq4ncdf 513 20 large large JJ cord-001397-nrq4ncdf 513 21 internal internal JJ cord-001397-nrq4ncdf 513 22 deletion deletion NN cord-001397-nrq4ncdf 513 23 ( ( -LRB- cord-001397-nrq4ncdf 513 24 Lancaster Lancaster NNP cord-001397-nrq4ncdf 513 25 et et NNP cord-001397-nrq4ncdf 513 26 al al NNP cord-001397-nrq4ncdf 513 27 . . NNP cord-001397-nrq4ncdf 513 28 , , , cord-001397-nrq4ncdf 513 29 1998 1998 CD cord-001397-nrq4ncdf 513 30 ) ) -RRB- cord-001397-nrq4ncdf 513 31 . . . cord-001397-nrq4ncdf 514 1 In in IN cord-001397-nrq4ncdf 514 2 this this DT cord-001397-nrq4ncdf 514 3 case case NN cord-001397-nrq4ncdf 514 4 , , , cord-001397-nrq4ncdf 514 5 MVE MVE NNP cord-001397-nrq4ncdf 514 6 DI DI NNP cord-001397-nrq4ncdf 514 7 particles particle NNS cord-001397-nrq4ncdf 514 8 reduced reduce VBD cord-001397-nrq4ncdf 514 9 the the DT cord-001397-nrq4ncdf 514 10 wild wild JJ cord-001397-nrq4ncdf 514 11 - - HYPH cord-001397-nrq4ncdf 514 12 type type NN cord-001397-nrq4ncdf 514 13 MVE MVE NNP cord-001397-nrq4ncdf 514 14 titer titer NN cord-001397-nrq4ncdf 514 15 by by IN cord-001397-nrq4ncdf 514 16 75 75 CD cord-001397-nrq4ncdf 514 17 - - SYM cord-001397-nrq4ncdf 514 18 95 95 CD cord-001397-nrq4ncdf 514 19 % % NN cord-001397-nrq4ncdf 514 20 ( ( -LRB- cord-001397-nrq4ncdf 514 21 Poidinger Poidinger NNP cord-001397-nrq4ncdf 514 22 et et NNP cord-001397-nrq4ncdf 514 23 al al NNP cord-001397-nrq4ncdf 514 24 . . NNP cord-001397-nrq4ncdf 514 25 , , , cord-001397-nrq4ncdf 514 26 1991 1991 CD cord-001397-nrq4ncdf 514 27 ) ) -RRB- cord-001397-nrq4ncdf 514 28 . . . cord-001397-nrq4ncdf 515 1 However however RB cord-001397-nrq4ncdf 515 2 , , , cord-001397-nrq4ncdf 515 3 a a DT cord-001397-nrq4ncdf 515 4 causal causal JJ cord-001397-nrq4ncdf 515 5 role role NN cord-001397-nrq4ncdf 515 6 for for IN cord-001397-nrq4ncdf 515 7 the the DT cord-001397-nrq4ncdf 515 8 MVE MVE NNP cord-001397-nrq4ncdf 515 9 DI DI NNP cord-001397-nrq4ncdf 515 10 particles particle NNS cord-001397-nrq4ncdf 515 11 in in IN cord-001397-nrq4ncdf 515 12 maintaining maintain VBG cord-001397-nrq4ncdf 515 13 persistent persistent JJ cord-001397-nrq4ncdf 515 14 infection infection NN cord-001397-nrq4ncdf 515 15 was be VBD cord-001397-nrq4ncdf 515 16 not not RB cord-001397-nrq4ncdf 515 17 conclusively conclusively RB cord-001397-nrq4ncdf 515 18 demonstrated demonstrate VBN cord-001397-nrq4ncdf 515 19 . . . cord-001397-nrq4ncdf 516 1 Studies study NNS cord-001397-nrq4ncdf 516 2 of of IN cord-001397-nrq4ncdf 516 3 the the DT cord-001397-nrq4ncdf 516 4 Far Far NNP cord-001397-nrq4ncdf 516 5 Eastern Eastern NNP cord-001397-nrq4ncdf 516 6 Sofjin Sofjin NNP cord-001397-nrq4ncdf 516 7 strain strain NN cord-001397-nrq4ncdf 516 8 of of IN cord-001397-nrq4ncdf 516 9 the the DT cord-001397-nrq4ncdf 516 10 TBEV TBEV NNP cord-001397-nrq4ncdf 516 11 complex complex NN cord-001397-nrq4ncdf 516 12 identified identify VBD cord-001397-nrq4ncdf 516 13 a a DT cord-001397-nrq4ncdf 516 14 39-kDa 39-kda CD cord-001397-nrq4ncdf 516 15 truncated truncated JJ cord-001397-nrq4ncdf 516 16 NS1 NS1 NNS cord-001397-nrq4ncdf 516 17 in in IN cord-001397-nrq4ncdf 516 18 both both CC cord-001397-nrq4ncdf 516 19 acutely acutely RB cord-001397-nrq4ncdf 516 20 and and CC cord-001397-nrq4ncdf 516 21 persistently persistently RB cord-001397-nrq4ncdf 516 22 infected infect VBN cord-001397-nrq4ncdf 516 23 human human JJ cord-001397-nrq4ncdf 516 24 kidney kidney NN cord-001397-nrq4ncdf 516 25 RH RH NNP cord-001397-nrq4ncdf 516 26 cells cell NNS cord-001397-nrq4ncdf 516 27 ( ( -LRB- cord-001397-nrq4ncdf 516 28 Bugrysheva Bugrysheva NNP cord-001397-nrq4ncdf 516 29 et et NNP cord-001397-nrq4ncdf 516 30 al al NNP cord-001397-nrq4ncdf 516 31 . . NNP cord-001397-nrq4ncdf 516 32 , , , cord-001397-nrq4ncdf 516 33 2001 2001 CD cord-001397-nrq4ncdf 516 34 ) ) -RRB- cord-001397-nrq4ncdf 516 35 . . . cord-001397-nrq4ncdf 517 1 For for IN cord-001397-nrq4ncdf 517 2 WNV WNV NNP cord-001397-nrq4ncdf 517 3 , , , cord-001397-nrq4ncdf 517 4 naturally naturally RB cord-001397-nrq4ncdf 517 5 occurring occur VBG cord-001397-nrq4ncdf 517 6 DI DI NNP cord-001397-nrq4ncdf 517 7 particles particle NNS cord-001397-nrq4ncdf 517 8 interfere interfere VBP cord-001397-nrq4ncdf 517 9 with with IN cord-001397-nrq4ncdf 517 10 transmission transmission NN cord-001397-nrq4ncdf 517 11 in in IN cord-001397-nrq4ncdf 517 12 mosquitoes mosquito NNS cord-001397-nrq4ncdf 517 13 and and CC cord-001397-nrq4ncdf 517 14 minimally minimally RB cord-001397-nrq4ncdf 517 15 impact impact NN cord-001397-nrq4ncdf 517 16 pathogenesis pathogenesis NN cord-001397-nrq4ncdf 517 17 in in IN cord-001397-nrq4ncdf 517 18 mice mouse NNS cord-001397-nrq4ncdf 518 1 ( ( -LRB- cord-001397-nrq4ncdf 518 2 Pesko Pesko NNP cord-001397-nrq4ncdf 518 3 et et NNP cord-001397-nrq4ncdf 518 4 al al NNP cord-001397-nrq4ncdf 518 5 . . NNP cord-001397-nrq4ncdf 518 6 , , , cord-001397-nrq4ncdf 518 7 2012 2012 CD cord-001397-nrq4ncdf 518 8 ) ) -RRB- cord-001397-nrq4ncdf 518 9 . . . cord-001397-nrq4ncdf 519 1 Furthermore furthermore RB cord-001397-nrq4ncdf 519 2 , , , cord-001397-nrq4ncdf 519 3 truncated truncate VBD cord-001397-nrq4ncdf 519 4 DENV DENV NNP cord-001397-nrq4ncdf 519 5 RNA RNA NNP cord-001397-nrq4ncdf 519 6 species specie NNS cord-001397-nrq4ncdf 519 7 , , , cord-001397-nrq4ncdf 519 8 suggesting suggest VBG cord-001397-nrq4ncdf 519 9 the the DT cord-001397-nrq4ncdf 519 10 presence presence NN cord-001397-nrq4ncdf 519 11 of of IN cord-001397-nrq4ncdf 519 12 DI DI NNP cord-001397-nrq4ncdf 519 13 particles particle NNS cord-001397-nrq4ncdf 519 14 , , , cord-001397-nrq4ncdf 519 15 have have VBP cord-001397-nrq4ncdf 519 16 been be VBN cord-001397-nrq4ncdf 519 17 identified identify VBN cord-001397-nrq4ncdf 519 18 in in IN cord-001397-nrq4ncdf 519 19 acute acute JJ cord-001397-nrq4ncdf 519 20 human human JJ cord-001397-nrq4ncdf 519 21 infections infection NNS cord-001397-nrq4ncdf 519 22 ( ( -LRB- cord-001397-nrq4ncdf 519 23 Li Li NNP cord-001397-nrq4ncdf 519 24 et et NNP cord-001397-nrq4ncdf 519 25 al al NNP cord-001397-nrq4ncdf 519 26 . . NNP cord-001397-nrq4ncdf 519 27 , , , cord-001397-nrq4ncdf 519 28 2011 2011 CD cord-001397-nrq4ncdf 519 29 ) ) -RRB- cord-001397-nrq4ncdf 519 30 , , , cord-001397-nrq4ncdf 519 31 but but CC cord-001397-nrq4ncdf 519 32 have have VBP cord-001397-nrq4ncdf 519 33 not not RB cord-001397-nrq4ncdf 519 34 been be VBN cord-001397-nrq4ncdf 519 35 described describe VBN cord-001397-nrq4ncdf 519 36 in in IN cord-001397-nrq4ncdf 519 37 other other JJ cord-001397-nrq4ncdf 519 38 acute acute JJ cord-001397-nrq4ncdf 519 39 VBFV VBFV NNP cord-001397-nrq4ncdf 519 40 infections infection NNS cord-001397-nrq4ncdf 519 41 in in IN cord-001397-nrq4ncdf 519 42 humans human NNS cord-001397-nrq4ncdf 519 43 . . . cord-001397-nrq4ncdf 520 1 Similarly similarly RB cord-001397-nrq4ncdf 520 2 , , , cord-001397-nrq4ncdf 520 3 Banzi Banzi NNP cord-001397-nrq4ncdf 520 4 virus virus NN cord-001397-nrq4ncdf 520 5 DI DI NNP cord-001397-nrq4ncdf 520 6 particles particle NNS cord-001397-nrq4ncdf 520 7 seem seem VBP cord-001397-nrq4ncdf 520 8 to to TO cord-001397-nrq4ncdf 520 9 have have VB cord-001397-nrq4ncdf 520 10 been be VBN cord-001397-nrq4ncdf 520 11 generated generate VBN cord-001397-nrq4ncdf 520 12 in in IN cord-001397-nrq4ncdf 520 13 resistant resistant JJ cord-001397-nrq4ncdf 520 14 C3H C3H NNP cord-001397-nrq4ncdf 520 15 / / SYM cord-001397-nrq4ncdf 520 16 RV RV NNP cord-001397-nrq4ncdf 520 17 mice mouse NNS cord-001397-nrq4ncdf 520 18 ( ( -LRB- cord-001397-nrq4ncdf 520 19 Smith Smith NNP cord-001397-nrq4ncdf 520 20 , , , cord-001397-nrq4ncdf 520 21 1981 1981 CD cord-001397-nrq4ncdf 520 22 ) ) -RRB- cord-001397-nrq4ncdf 520 23 . . . cord-001397-nrq4ncdf 521 1 Although although IN cord-001397-nrq4ncdf 521 2 DI DI NNP cord-001397-nrq4ncdf 521 3 particles particle NNS cord-001397-nrq4ncdf 521 4 and and CC cord-001397-nrq4ncdf 521 5 the the DT cord-001397-nrq4ncdf 521 6 truncated truncated JJ cord-001397-nrq4ncdf 521 7 NS1 NS1 NNS cord-001397-nrq4ncdf 521 8 may may MD cord-001397-nrq4ncdf 521 9 be be VB cord-001397-nrq4ncdf 521 10 frequently frequently RB cord-001397-nrq4ncdf 521 11 observed observe VBN cord-001397-nrq4ncdf 521 12 in in IN cord-001397-nrq4ncdf 521 13 persistent persistent JJ cord-001397-nrq4ncdf 521 14 infections infection NNS cord-001397-nrq4ncdf 521 15 , , , cord-001397-nrq4ncdf 521 16 it -PRON- PRP cord-001397-nrq4ncdf 521 17 is be VBZ cord-001397-nrq4ncdf 521 18 not not RB cord-001397-nrq4ncdf 521 19 at at RB cord-001397-nrq4ncdf 521 20 all all RB cord-001397-nrq4ncdf 521 21 clear clear JJ cord-001397-nrq4ncdf 521 22 that that IN cord-001397-nrq4ncdf 521 23 they -PRON- PRP cord-001397-nrq4ncdf 521 24 are be VBP cord-001397-nrq4ncdf 521 25 independently independently RB cord-001397-nrq4ncdf 521 26 sufficient sufficient JJ cord-001397-nrq4ncdf 521 27 for for IN cord-001397-nrq4ncdf 521 28 the the DT cord-001397-nrq4ncdf 521 29 establishment establishment NN cord-001397-nrq4ncdf 521 30 and and CC cord-001397-nrq4ncdf 521 31 maintenance maintenance NN cord-001397-nrq4ncdf 521 32 of of IN cord-001397-nrq4ncdf 521 33 a a DT cord-001397-nrq4ncdf 521 34 persistent persistent JJ cord-001397-nrq4ncdf 521 35 infection infection NN cord-001397-nrq4ncdf 521 36 in in IN cord-001397-nrq4ncdf 521 37 vitro vitro FW cord-001397-nrq4ncdf 521 38 or or CC cord-001397-nrq4ncdf 521 39 in in IN cord-001397-nrq4ncdf 521 40 vivo vivo NNP cord-001397-nrq4ncdf 521 41 . . . cord-001397-nrq4ncdf 522 1 Stable stable JJ cord-001397-nrq4ncdf 522 2 expression expression NN cord-001397-nrq4ncdf 522 3 of of IN cord-001397-nrq4ncdf 522 4 truncated truncated JJ cord-001397-nrq4ncdf 522 5 NS1 NS1 NNS cord-001397-nrq4ncdf 522 6 failed fail VBD cord-001397-nrq4ncdf 522 7 to to TO cord-001397-nrq4ncdf 522 8 render render VB cord-001397-nrq4ncdf 522 9 persistent persistent JJ cord-001397-nrq4ncdf 522 10 infection infection NN cord-001397-nrq4ncdf 522 11 with with IN cord-001397-nrq4ncdf 522 12 JEV JEV NNP cord-001397-nrq4ncdf 522 13 , , , cord-001397-nrq4ncdf 522 14 suggesting suggest VBG cord-001397-nrq4ncdf 522 15 that that IN cord-001397-nrq4ncdf 522 16 truncated truncated JJ cord-001397-nrq4ncdf 522 17 NS1 NS1 NNS cord-001397-nrq4ncdf 522 18 is be VBZ cord-001397-nrq4ncdf 522 19 a a DT cord-001397-nrq4ncdf 522 20 consequence consequence NN cord-001397-nrq4ncdf 522 21 rather rather RB cord-001397-nrq4ncdf 522 22 than than IN cord-001397-nrq4ncdf 522 23 a a DT cord-001397-nrq4ncdf 522 24 cause cause NN cord-001397-nrq4ncdf 522 25 for for IN cord-001397-nrq4ncdf 522 26 viral viral JJ cord-001397-nrq4ncdf 522 27 persistence persistence NN cord-001397-nrq4ncdf 522 28 ( ( -LRB- cord-001397-nrq4ncdf 522 29 Liao Liao NNP cord-001397-nrq4ncdf 522 30 et et FW cord-001397-nrq4ncdf 522 31 al al NNP cord-001397-nrq4ncdf 522 32 . . NNP cord-001397-nrq4ncdf 522 33 , , , cord-001397-nrq4ncdf 522 34 1998 1998 CD cord-001397-nrq4ncdf 522 35 ) ) -RRB- cord-001397-nrq4ncdf 522 36 . . . cord-001397-nrq4ncdf 523 1 The the DT cord-001397-nrq4ncdf 523 2 role role NN cord-001397-nrq4ncdf 523 3 of of IN cord-001397-nrq4ncdf 523 4 DI DI NNP cord-001397-nrq4ncdf 523 5 particles particle NNS cord-001397-nrq4ncdf 523 6 merits merit NNS cord-001397-nrq4ncdf 523 7 further further JJ cord-001397-nrq4ncdf 523 8 investigation investigation NN cord-001397-nrq4ncdf 523 9 , , , cord-001397-nrq4ncdf 523 10 but but CC cord-001397-nrq4ncdf 523 11 the the DT cord-001397-nrq4ncdf 523 12 role role NN cord-001397-nrq4ncdf 523 13 of of IN cord-001397-nrq4ncdf 523 14 other other JJ cord-001397-nrq4ncdf 523 15 aspects aspect NNS cord-001397-nrq4ncdf 523 16 of of IN cord-001397-nrq4ncdf 523 17 virus virus NN cord-001397-nrq4ncdf 523 18 biology biology NN cord-001397-nrq4ncdf 523 19 should should MD cord-001397-nrq4ncdf 523 20 also also RB cord-001397-nrq4ncdf 523 21 be be VB cord-001397-nrq4ncdf 523 22 scrutinized scrutinize VBN cord-001397-nrq4ncdf 523 23 . . . cord-001397-nrq4ncdf 524 1 Restricted restricted JJ cord-001397-nrq4ncdf 524 2 expression expression NN cord-001397-nrq4ncdf 524 3 of of IN cord-001397-nrq4ncdf 524 4 the the DT cord-001397-nrq4ncdf 524 5 envelope envelope NN cord-001397-nrq4ncdf 524 6 ( ( -LRB- cord-001397-nrq4ncdf 524 7 E e NN cord-001397-nrq4ncdf 524 8 ) ) -RRB- cord-001397-nrq4ncdf 524 9 protein protein NN cord-001397-nrq4ncdf 524 10 may may MD cord-001397-nrq4ncdf 524 11 also also RB cord-001397-nrq4ncdf 524 12 favor favor VB cord-001397-nrq4ncdf 524 13 development development NN cord-001397-nrq4ncdf 524 14 of of IN cord-001397-nrq4ncdf 524 15 persistence persistence NN cord-001397-nrq4ncdf 524 16 . . . cord-001397-nrq4ncdf 525 1 In in IN cord-001397-nrq4ncdf 525 2 KN73 KN73 NNP cord-001397-nrq4ncdf 525 3 cells cell NNS cord-001397-nrq4ncdf 525 4 that that WDT cord-001397-nrq4ncdf 525 5 were be VBD cord-001397-nrq4ncdf 525 6 persistently persistently RB cord-001397-nrq4ncdf 525 7 infected infect VBN cord-001397-nrq4ncdf 525 8 with with IN cord-001397-nrq4ncdf 525 9 JEV JEV NNP cord-001397-nrq4ncdf 525 10 , , , cord-001397-nrq4ncdf 525 11 the the DT cord-001397-nrq4ncdf 525 12 E e NN cord-001397-nrq4ncdf 525 13 protein protein NN cord-001397-nrq4ncdf 525 14 was be VBD cord-001397-nrq4ncdf 525 15 found find VBN cord-001397-nrq4ncdf 525 16 to to TO cord-001397-nrq4ncdf 525 17 be be VB cord-001397-nrq4ncdf 525 18 expressed express VBN cord-001397-nrq4ncdf 525 19 at at IN cord-001397-nrq4ncdf 525 20 markedly markedly RB cord-001397-nrq4ncdf 525 21 low low JJ cord-001397-nrq4ncdf 525 22 levels level NNS cord-001397-nrq4ncdf 525 23 compared compare VBN cord-001397-nrq4ncdf 525 24 with with IN cord-001397-nrq4ncdf 525 25 acutely acutely RB cord-001397-nrq4ncdf 525 26 infected infect VBN cord-001397-nrq4ncdf 525 27 cells cell NNS cord-001397-nrq4ncdf 525 28 ( ( -LRB- cord-001397-nrq4ncdf 525 29 Feng Feng NNP cord-001397-nrq4ncdf 525 30 et et FW cord-001397-nrq4ncdf 525 31 al al NNP cord-001397-nrq4ncdf 525 32 . . NNP cord-001397-nrq4ncdf 525 33 , , , cord-001397-nrq4ncdf 525 34 2002 2002 CD cord-001397-nrq4ncdf 525 35 ) ) -RRB- cord-001397-nrq4ncdf 525 36 . . . cord-001397-nrq4ncdf 526 1 In in IN cord-001397-nrq4ncdf 526 2 these these DT cord-001397-nrq4ncdf 526 3 studies study NNS cord-001397-nrq4ncdf 526 4 , , , cord-001397-nrq4ncdf 526 5 the the DT cord-001397-nrq4ncdf 526 6 expression expression NN cord-001397-nrq4ncdf 526 7 of of IN cord-001397-nrq4ncdf 526 8 NS3 NS3 NNP cord-001397-nrq4ncdf 526 9 was be VBD cord-001397-nrq4ncdf 526 10 found find VBN cord-001397-nrq4ncdf 526 11 to to TO cord-001397-nrq4ncdf 526 12 be be VB cord-001397-nrq4ncdf 526 13 unchanged unchanged JJ cord-001397-nrq4ncdf 526 14 in in IN cord-001397-nrq4ncdf 526 15 the the DT cord-001397-nrq4ncdf 526 16 acute acute JJ cord-001397-nrq4ncdf 526 17 and and CC cord-001397-nrq4ncdf 526 18 persistent persistent JJ cord-001397-nrq4ncdf 526 19 phases phase NNS cord-001397-nrq4ncdf 526 20 of of IN cord-001397-nrq4ncdf 526 21 JEV JEV NNP cord-001397-nrq4ncdf 526 22 infection infection NN cord-001397-nrq4ncdf 527 1 ( ( -LRB- cord-001397-nrq4ncdf 527 2 Feng Feng NNP cord-001397-nrq4ncdf 527 3 et et FW cord-001397-nrq4ncdf 527 4 al al NNP cord-001397-nrq4ncdf 527 5 . . NNP cord-001397-nrq4ncdf 527 6 , , , cord-001397-nrq4ncdf 527 7 2002 2002 CD cord-001397-nrq4ncdf 527 8 ) ) -RRB- cord-001397-nrq4ncdf 527 9 . . . cord-001397-nrq4ncdf 528 1 As as IN cord-001397-nrq4ncdf 528 2 the the DT cord-001397-nrq4ncdf 528 3 E e NN cord-001397-nrq4ncdf 528 4 protein protein NN cord-001397-nrq4ncdf 528 5 is be VBZ cord-001397-nrq4ncdf 528 6 important important JJ cord-001397-nrq4ncdf 528 7 for for IN cord-001397-nrq4ncdf 528 8 pathogenesis pathogenesis NN cord-001397-nrq4ncdf 528 9 and and CC cord-001397-nrq4ncdf 528 10 immunity immunity NN cord-001397-nrq4ncdf 528 11 ( ( -LRB- cord-001397-nrq4ncdf 528 12 CDC CDC NNP cord-001397-nrq4ncdf 528 13 , , , cord-001397-nrq4ncdf 528 14 2009 2009 CD cord-001397-nrq4ncdf 528 15 ) ) -RRB- cord-001397-nrq4ncdf 528 16 , , , cord-001397-nrq4ncdf 528 17 low low JJ cord-001397-nrq4ncdf 528 18 - - HYPH cord-001397-nrq4ncdf 528 19 level level NN cord-001397-nrq4ncdf 528 20 expression expression NN cord-001397-nrq4ncdf 528 21 could could MD cord-001397-nrq4ncdf 528 22 result result VB cord-001397-nrq4ncdf 528 23 in in IN cord-001397-nrq4ncdf 528 24 immune immune JJ cord-001397-nrq4ncdf 528 25 tolerance tolerance NN cord-001397-nrq4ncdf 528 26 and and CC cord-001397-nrq4ncdf 528 27 contribute contribute VB cord-001397-nrq4ncdf 528 28 toward toward IN cord-001397-nrq4ncdf 528 29 viral viral JJ cord-001397-nrq4ncdf 528 30 persistence persistence NN cord-001397-nrq4ncdf 528 31 . . . cord-001397-nrq4ncdf 529 1 In in IN cord-001397-nrq4ncdf 529 2 addition addition NN cord-001397-nrq4ncdf 529 3 to to IN cord-001397-nrq4ncdf 529 4 low low JJ cord-001397-nrq4ncdf 529 5 expression expression NN cord-001397-nrq4ncdf 529 6 levels level NNS cord-001397-nrq4ncdf 529 7 , , , cord-001397-nrq4ncdf 529 8 mutations mutation NNS cord-001397-nrq4ncdf 529 9 in in IN cord-001397-nrq4ncdf 529 10 the the DT cord-001397-nrq4ncdf 529 11 E e NN cord-001397-nrq4ncdf 529 12 protein protein NN cord-001397-nrq4ncdf 529 13 of of IN cord-001397-nrq4ncdf 529 14 JEV JEV NNP cord-001397-nrq4ncdf 529 15 , , , cord-001397-nrq4ncdf 529 16 YFV YFV NNP cord-001397-nrq4ncdf 529 17 , , , cord-001397-nrq4ncdf 529 18 and and CC cord-001397-nrq4ncdf 529 19 WNV WNV NNP cord-001397-nrq4ncdf 529 20 might may MD cord-001397-nrq4ncdf 529 21 also also RB cord-001397-nrq4ncdf 529 22 play play VB cord-001397-nrq4ncdf 529 23 a a DT cord-001397-nrq4ncdf 529 24 role role NN cord-001397-nrq4ncdf 529 25 in in IN cord-001397-nrq4ncdf 529 26 VBFV VBFV NNP cord-001397-nrq4ncdf 529 27 persistence persistence NN cord-001397-nrq4ncdf 530 1 ( ( -LRB- cord-001397-nrq4ncdf 530 2 Ding Ding NNP cord-001397-nrq4ncdf 530 3 et et FW cord-001397-nrq4ncdf 530 4 al al NNP cord-001397-nrq4ncdf 530 5 . . NNP cord-001397-nrq4ncdf 530 6 , , , cord-001397-nrq4ncdf 530 7 2005 2005 CD cord-001397-nrq4ncdf 530 8 ; ; : cord-001397-nrq4ncdf 531 1 Farfan Farfan NNP cord-001397-nrq4ncdf 531 2 - - HYPH cord-001397-nrq4ncdf 531 3 Ale Ale NNP cord-001397-nrq4ncdf 531 4 et et FW cord-001397-nrq4ncdf 531 5 al al NNP cord-001397-nrq4ncdf 531 6 . . NNP cord-001397-nrq4ncdf 531 7 , , , cord-001397-nrq4ncdf 531 8 2009 2009 CD cord-001397-nrq4ncdf 531 9 ) ) -RRB- cord-001397-nrq4ncdf 531 10 . . . cord-001397-nrq4ncdf 532 1 A a DT cord-001397-nrq4ncdf 532 2 138E?K 138e?k CD cord-001397-nrq4ncdf 532 3 mutation mutation NN cord-001397-nrq4ncdf 532 4 in in IN cord-001397-nrq4ncdf 532 5 the the DT cord-001397-nrq4ncdf 532 6 E e NN cord-001397-nrq4ncdf 532 7 protein protein NN cord-001397-nrq4ncdf 532 8 of of IN cord-001397-nrq4ncdf 532 9 JEV JEV NNP cord-001397-nrq4ncdf 532 10 and and CC cord-001397-nrq4ncdf 532 11 WNV WNV NNP cord-001397-nrq4ncdf 532 12 was be VBD cord-001397-nrq4ncdf 532 13 shown show VBN cord-001397-nrq4ncdf 532 14 to to TO cord-001397-nrq4ncdf 532 15 inhibit inhibit VB cord-001397-nrq4ncdf 532 16 cell cell NN cord-001397-nrq4ncdf 532 17 - - HYPH cord-001397-nrq4ncdf 532 18 cell cell NN cord-001397-nrq4ncdf 532 19 spread spread NN cord-001397-nrq4ncdf 532 20 of of IN cord-001397-nrq4ncdf 532 21 the the DT cord-001397-nrq4ncdf 532 22 virus virus NN cord-001397-nrq4ncdf 532 23 and and CC cord-001397-nrq4ncdf 532 24 to to TO cord-001397-nrq4ncdf 532 25 contribute contribute VB cord-001397-nrq4ncdf 532 26 toward toward IN cord-001397-nrq4ncdf 532 27 the the DT cord-001397-nrq4ncdf 532 28 development development NN cord-001397-nrq4ncdf 532 29 of of IN cord-001397-nrq4ncdf 532 30 a a DT cord-001397-nrq4ncdf 532 31 small small JJ cord-001397-nrq4ncdf 532 32 - - HYPH cord-001397-nrq4ncdf 532 33 plaque plaque NN cord-001397-nrq4ncdf 532 34 phenotype phenotype NN cord-001397-nrq4ncdf 532 35 ( ( -LRB- cord-001397-nrq4ncdf 532 36 Carson Carson NNP cord-001397-nrq4ncdf 532 37 et et NNP cord-001397-nrq4ncdf 532 38 al al NNP cord-001397-nrq4ncdf 532 39 . . NNP cord-001397-nrq4ncdf 532 40 , , , cord-001397-nrq4ncdf 532 41 2006 2006 CD cord-001397-nrq4ncdf 532 42 ) ) -RRB- cord-001397-nrq4ncdf 532 43 . . . cord-001397-nrq4ncdf 533 1 While while IN cord-001397-nrq4ncdf 533 2 this this DT cord-001397-nrq4ncdf 533 3 mutation mutation NN cord-001397-nrq4ncdf 533 4 leads lead VBZ cord-001397-nrq4ncdf 533 5 to to IN cord-001397-nrq4ncdf 533 6 viral viral JJ cord-001397-nrq4ncdf 533 7 attenuation attenuation NN cord-001397-nrq4ncdf 533 8 ( ( -LRB- cord-001397-nrq4ncdf 533 9 Carson Carson NNP cord-001397-nrq4ncdf 533 10 et et NNP cord-001397-nrq4ncdf 533 11 al al NNP cord-001397-nrq4ncdf 533 12 . . NNP cord-001397-nrq4ncdf 533 13 , , , cord-001397-nrq4ncdf 533 14 2006 2006 CD cord-001397-nrq4ncdf 533 15 ) ) -RRB- cord-001397-nrq4ncdf 533 16 and and CC cord-001397-nrq4ncdf 533 17 is be VBZ cord-001397-nrq4ncdf 533 18 key key JJ cord-001397-nrq4ncdf 533 19 in in IN cord-001397-nrq4ncdf 533 20 the the DT cord-001397-nrq4ncdf 533 21 attenuation attenuation NN cord-001397-nrq4ncdf 533 22 of of IN cord-001397-nrq4ncdf 533 23 JEV JEV NNP cord-001397-nrq4ncdf 533 24 SA14 SA14 NNP cord-001397-nrq4ncdf 533 25 - - HYPH cord-001397-nrq4ncdf 533 26 14 14 CD cord-001397-nrq4ncdf 533 27 - - SYM cord-001397-nrq4ncdf 533 28 2 2 CD cord-001397-nrq4ncdf 533 29 vaccine vaccine NN cord-001397-nrq4ncdf 533 30 ( ( -LRB- cord-001397-nrq4ncdf 533 31 Monath Monath NNP cord-001397-nrq4ncdf 533 32 et et NNP cord-001397-nrq4ncdf 533 33 al al NNP cord-001397-nrq4ncdf 533 34 . . NNP cord-001397-nrq4ncdf 533 35 , , , cord-001397-nrq4ncdf 533 36 2002 2002 CD cord-001397-nrq4ncdf 533 37 ) ) -RRB- cord-001397-nrq4ncdf 533 38 , , , cord-001397-nrq4ncdf 533 39 further further JJ cord-001397-nrq4ncdf 533 40 elucidation elucidation NN cord-001397-nrq4ncdf 533 41 of of IN cord-001397-nrq4ncdf 533 42 mutations mutation NNS cord-001397-nrq4ncdf 533 43 that that WDT cord-001397-nrq4ncdf 533 44 may may MD cord-001397-nrq4ncdf 533 45 play play VB cord-001397-nrq4ncdf 533 46 a a DT cord-001397-nrq4ncdf 533 47 role role NN cord-001397-nrq4ncdf 533 48 in in IN cord-001397-nrq4ncdf 533 49 persistence persistence NN cord-001397-nrq4ncdf 533 50 is be VBZ cord-001397-nrq4ncdf 533 51 required require VBN cord-001397-nrq4ncdf 533 52 . . . cord-001397-nrq4ncdf 534 1 Observations observation NNS cord-001397-nrq4ncdf 534 2 that that IN cord-001397-nrq4ncdf 534 3 hamsters hamster NNS cord-001397-nrq4ncdf 534 4 and and CC cord-001397-nrq4ncdf 534 5 mice mouse NNS cord-001397-nrq4ncdf 534 6 infected infect VBN cord-001397-nrq4ncdf 534 7 with with IN cord-001397-nrq4ncdf 534 8 MBFVs mbfv NNS cord-001397-nrq4ncdf 534 9 obtained obtain VBN cord-001397-nrq4ncdf 534 10 from from IN cord-001397-nrq4ncdf 534 11 urine urine NN cord-001397-nrq4ncdf 534 12 of of IN cord-001397-nrq4ncdf 534 13 other other JJ cord-001397-nrq4ncdf 534 14 MBFV MBFV NNP cord-001397-nrq4ncdf 534 15 - - HYPH cord-001397-nrq4ncdf 534 16 infected infect VBN cord-001397-nrq4ncdf 534 17 animals animal NNS cord-001397-nrq4ncdf 534 18 do do VBP cord-001397-nrq4ncdf 534 19 not not RB cord-001397-nrq4ncdf 534 20 suffer suffer VB cord-001397-nrq4ncdf 534 21 severe severe JJ cord-001397-nrq4ncdf 534 22 disease disease NN cord-001397-nrq4ncdf 534 23 and and CC cord-001397-nrq4ncdf 534 24 become become VBP cord-001397-nrq4ncdf 534 25 persistently persistently RB cord-001397-nrq4ncdf 534 26 infected infect VBN cord-001397-nrq4ncdf 534 27 indicate indicate VBP cord-001397-nrq4ncdf 534 28 that that IN cord-001397-nrq4ncdf 534 29 the the DT cord-001397-nrq4ncdf 534 30 virus virus NN cord-001397-nrq4ncdf 534 31 is be VBZ cord-001397-nrq4ncdf 534 32 attenuated attenuate VBN cord-001397-nrq4ncdf 534 33 ( ( -LRB- cord-001397-nrq4ncdf 534 34 Rosen Rosen NNP cord-001397-nrq4ncdf 534 35 et et NNP cord-001397-nrq4ncdf 534 36 al al NNP cord-001397-nrq4ncdf 534 37 . . NNP cord-001397-nrq4ncdf 534 38 , , , cord-001397-nrq4ncdf 534 39 1983 1983 CD cord-001397-nrq4ncdf 534 40 ; ; . cord-001397-nrq4ncdf 535 1 Ding Ding NNP cord-001397-nrq4ncdf 535 2 et et FW cord-001397-nrq4ncdf 535 3 al al NNP cord-001397-nrq4ncdf 535 4 . . NNP cord-001397-nrq4ncdf 535 5 , , , cord-001397-nrq4ncdf 535 6 2005 2005 CD cord-001397-nrq4ncdf 535 7 ) ) -RRB- cord-001397-nrq4ncdf 535 8 . . . cord-001397-nrq4ncdf 536 1 A a DT cord-001397-nrq4ncdf 536 2 number number NN cord-001397-nrq4ncdf 536 3 of of IN cord-001397-nrq4ncdf 536 4 amino amino NN cord-001397-nrq4ncdf 536 5 acid acid NN cord-001397-nrq4ncdf 536 6 - - HYPH cord-001397-nrq4ncdf 536 7 changing change VBG cord-001397-nrq4ncdf 536 8 mutations mutation NNS cord-001397-nrq4ncdf 536 9 in in IN cord-001397-nrq4ncdf 536 10 C C NNP cord-001397-nrq4ncdf 536 11 , , , cord-001397-nrq4ncdf 536 12 E E NNP cord-001397-nrq4ncdf 536 13 , , , cord-001397-nrq4ncdf 536 14 NS1 ns1 UH cord-001397-nrq4ncdf 536 15 , , , cord-001397-nrq4ncdf 536 16 NS2A NS2A NNP cord-001397-nrq4ncdf 536 17 , , , cord-001397-nrq4ncdf 536 18 NS2B NS2B NNP cord-001397-nrq4ncdf 536 19 , , , cord-001397-nrq4ncdf 536 20 and and CC cord-001397-nrq4ncdf 536 21 NS5 ns5 JJ cord-001397-nrq4ncdf 536 22 were be VBD cord-001397-nrq4ncdf 536 23 reportedly reportedly RB cord-001397-nrq4ncdf 536 24 associated associate VBN cord-001397-nrq4ncdf 536 25 with with IN cord-001397-nrq4ncdf 536 26 persistence persistence NN cord-001397-nrq4ncdf 536 27 of of IN cord-001397-nrq4ncdf 536 28 WNV WNV NNP cord-001397-nrq4ncdf 536 29 in in IN cord-001397-nrq4ncdf 536 30 serially serially RB cord-001397-nrq4ncdf 536 31 passaged passage VBN cord-001397-nrq4ncdf 536 32 hamsters hamster NNS cord-001397-nrq4ncdf 536 33 ( ( -LRB- cord-001397-nrq4ncdf 536 34 S S NNP cord-001397-nrq4ncdf 536 35 anchez- anchez- NN cord-001397-nrq4ncdf 536 36 Vargas Vargas NNP cord-001397-nrq4ncdf 536 37 et et NNP cord-001397-nrq4ncdf 536 38 al al NNP cord-001397-nrq4ncdf 536 39 . . NNP cord-001397-nrq4ncdf 536 40 , , , cord-001397-nrq4ncdf 536 41 2009 2009 CD cord-001397-nrq4ncdf 536 42 ) ) -RRB- cord-001397-nrq4ncdf 536 43 . . . cord-001397-nrq4ncdf 537 1 These these DT cord-001397-nrq4ncdf 537 2 mutations mutation NNS cord-001397-nrq4ncdf 537 3 are be VBP cord-001397-nrq4ncdf 537 4 thought think VBN cord-001397-nrq4ncdf 537 5 to to TO cord-001397-nrq4ncdf 537 6 have have VB cord-001397-nrq4ncdf 537 7 attenuated attenuate VBN cord-001397-nrq4ncdf 537 8 the the DT cord-001397-nrq4ncdf 537 9 virus virus NN cord-001397-nrq4ncdf 537 10 ( ( -LRB- cord-001397-nrq4ncdf 537 11 S S NNP cord-001397-nrq4ncdf 537 12 anchez- anchez- NN cord-001397-nrq4ncdf 537 13 Vargas Vargas NNP cord-001397-nrq4ncdf 537 14 et et NNP cord-001397-nrq4ncdf 537 15 al al NNP cord-001397-nrq4ncdf 537 16 . . NNP cord-001397-nrq4ncdf 537 17 , , , cord-001397-nrq4ncdf 537 18 2009 2009 CD cord-001397-nrq4ncdf 537 19 ) ) -RRB- cord-001397-nrq4ncdf 537 20 . . . cord-001397-nrq4ncdf 538 1 However however RB cord-001397-nrq4ncdf 538 2 , , , cord-001397-nrq4ncdf 538 3 the the DT cord-001397-nrq4ncdf 538 4 same same JJ cord-001397-nrq4ncdf 538 5 mutations mutation NNS cord-001397-nrq4ncdf 538 6 have have VBP cord-001397-nrq4ncdf 538 7 not not RB cord-001397-nrq4ncdf 538 8 been be VBN cord-001397-nrq4ncdf 538 9 reported report VBN cord-001397-nrq4ncdf 538 10 by by IN cord-001397-nrq4ncdf 538 11 other other JJ cord-001397-nrq4ncdf 538 12 groups group NNS cord-001397-nrq4ncdf 538 13 , , , cord-001397-nrq4ncdf 538 14 suggesting suggest VBG cord-001397-nrq4ncdf 538 15 that that IN cord-001397-nrq4ncdf 538 16 the the DT cord-001397-nrq4ncdf 538 17 mutations mutation NNS cord-001397-nrq4ncdf 538 18 may may MD cord-001397-nrq4ncdf 538 19 not not RB cord-001397-nrq4ncdf 538 20 be be VB cord-001397-nrq4ncdf 538 21 specific specific JJ cord-001397-nrq4ncdf 538 22 to to IN cord-001397-nrq4ncdf 538 23 development development NN cord-001397-nrq4ncdf 538 24 or or CC cord-001397-nrq4ncdf 538 25 maintenance maintenance NN cord-001397-nrq4ncdf 538 26 of of IN cord-001397-nrq4ncdf 538 27 viral viral JJ cord-001397-nrq4ncdf 538 28 persistence persistence NN cord-001397-nrq4ncdf 538 29 . . . cord-001397-nrq4ncdf 539 1 Mechanisms mechanism NNS cord-001397-nrq4ncdf 539 2 not not RB cord-001397-nrq4ncdf 539 3 directly directly RB cord-001397-nrq4ncdf 539 4 involving involve VBG cord-001397-nrq4ncdf 539 5 viral viral JJ cord-001397-nrq4ncdf 539 6 proteins protein NNS cord-001397-nrq4ncdf 539 7 may may MD cord-001397-nrq4ncdf 539 8 also also RB cord-001397-nrq4ncdf 539 9 play play VB cord-001397-nrq4ncdf 539 10 a a DT cord-001397-nrq4ncdf 539 11 significant significant JJ cord-001397-nrq4ncdf 539 12 role role NN cord-001397-nrq4ncdf 539 13 in in IN cord-001397-nrq4ncdf 539 14 persistence persistence NN cord-001397-nrq4ncdf 539 15 . . . cord-001397-nrq4ncdf 540 1 For for IN cord-001397-nrq4ncdf 540 2 instance instance NN cord-001397-nrq4ncdf 540 3 , , , cord-001397-nrq4ncdf 540 4 JEV JEV NNP cord-001397-nrq4ncdf 540 5 delays delay VBZ cord-001397-nrq4ncdf 540 6 the the DT cord-001397-nrq4ncdf 540 7 exposure exposure NN cord-001397-nrq4ncdf 540 8 of of IN cord-001397-nrq4ncdf 540 9 dsRNA dsrna NN cord-001397-nrq4ncdf 540 10 to to TO cord-001397-nrq4ncdf 540 11 innate innate JJ cord-001397-nrq4ncdf 540 12 sensors sensor NNS cord-001397-nrq4ncdf 540 13 and and CC cord-001397-nrq4ncdf 540 14 inhibits inhibit VBZ cord-001397-nrq4ncdf 540 15 phosphorylation phosphorylation NN cord-001397-nrq4ncdf 540 16 of of IN cord-001397-nrq4ncdf 540 17 IRF3 IRF3 NNP cord-001397-nrq4ncdf 540 18 via via IN cord-001397-nrq4ncdf 540 19 noncoding noncoding JJ cord-001397-nrq4ncdf 540 20 viral viral JJ cord-001397-nrq4ncdf 540 21 short short NNP cord-001397-nrq4ncdf 540 22 flaviviral flaviviral NNP cord-001397-nrq4ncdf 540 23 RNA RNA NNP cord-001397-nrq4ncdf 540 24 ( ( -LRB- cord-001397-nrq4ncdf 540 25 Espada Espada NNP cord-001397-nrq4ncdf 540 26 - - HYPH cord-001397-nrq4ncdf 540 27 Murao Murao NNP cord-001397-nrq4ncdf 540 28 & & CC cord-001397-nrq4ncdf 540 29 Morita Morita NNP cord-001397-nrq4ncdf 540 30 , , , cord-001397-nrq4ncdf 540 31 2011 2011 CD cord-001397-nrq4ncdf 540 32 ; ; : cord-001397-nrq4ncdf 540 33 Chang Chang NNP cord-001397-nrq4ncdf 540 34 et et NNP cord-001397-nrq4ncdf 540 35 al al NNP cord-001397-nrq4ncdf 540 36 . . . cord-001397-nrq4ncdf 541 1 , , , cord-001397-nrq4ncdf 541 2 2013 2013 CD cord-001397-nrq4ncdf 541 3 ) ) -RRB- cord-001397-nrq4ncdf 541 4 . . . cord-001397-nrq4ncdf 542 1 Similarly similarly RB cord-001397-nrq4ncdf 542 2 , , , cord-001397-nrq4ncdf 542 3 WNV WNV NNP cord-001397-nrq4ncdf 542 4 delays delay NNS cord-001397-nrq4ncdf 542 5 recognition recognition NN cord-001397-nrq4ncdf 542 6 by by IN cord-001397-nrq4ncdf 542 7 pathogen pathogen NN cord-001397-nrq4ncdf 542 8 recognition recognition NN cord-001397-nrq4ncdf 542 9 receptors receptor NNS cord-001397-nrq4ncdf 542 10 by by IN cord-001397-nrq4ncdf 542 11 activating activate VBG cord-001397-nrq4ncdf 542 12 IRF3 IRF3 NNP cord-001397-nrq4ncdf 542 13 in in IN cord-001397-nrq4ncdf 542 14 a a DT cord-001397-nrq4ncdf 542 15 RIG rig NN cord-001397-nrq4ncdf 542 16 - - HYPH cord-001397-nrq4ncdf 542 17 I i NN cord-001397-nrq4ncdf 542 18 - - HYPH cord-001397-nrq4ncdf 542 19 dependent dependent JJ cord-001397-nrq4ncdf 542 20 manner manner NN cord-001397-nrq4ncdf 542 21 without without IN cord-001397-nrq4ncdf 542 22 antagonizing antagonize VBG cord-001397-nrq4ncdf 542 23 the the DT cord-001397-nrq4ncdf 542 24 host host NN cord-001397-nrq4ncdf 542 25 IFN IFN NNP cord-001397-nrq4ncdf 542 26 response response NN cord-001397-nrq4ncdf 542 27 ( ( -LRB- cord-001397-nrq4ncdf 542 28 Fredericksen Fredericksen NNP cord-001397-nrq4ncdf 542 29 & & CC cord-001397-nrq4ncdf 542 30 Gale Gale NNP cord-001397-nrq4ncdf 542 31 , , , cord-001397-nrq4ncdf 542 32 2006 2006 CD cord-001397-nrq4ncdf 542 33 ) ) -RRB- cord-001397-nrq4ncdf 542 34 . . . cord-001397-nrq4ncdf 543 1 The the DT cord-001397-nrq4ncdf 543 2 mechanism mechanism NN cord-001397-nrq4ncdf 543 3 of of IN cord-001397-nrq4ncdf 543 4 evasion evasion NN cord-001397-nrq4ncdf 543 5 is be VBZ cord-001397-nrq4ncdf 543 6 currently currently RB cord-001397-nrq4ncdf 543 7 not not RB cord-001397-nrq4ncdf 543 8 clear clear JJ cord-001397-nrq4ncdf 543 9 , , , cord-001397-nrq4ncdf 543 10 but but CC cord-001397-nrq4ncdf 543 11 membrane membrane NN cord-001397-nrq4ncdf 543 12 - - HYPH cord-001397-nrq4ncdf 543 13 bound bind VBN cord-001397-nrq4ncdf 543 14 vesicles vesicle NNS cord-001397-nrq4ncdf 543 15 that that WDT cord-001397-nrq4ncdf 543 16 enclose enclose VBP cord-001397-nrq4ncdf 543 17 the the DT cord-001397-nrq4ncdf 543 18 RIG rig NN cord-001397-nrq4ncdf 543 19 - - HYPH cord-001397-nrq4ncdf 543 20 I I NNP cord-001397-nrq4ncdf 543 21 - - HYPH cord-001397-nrq4ncdf 543 22 activating activate VBG cord-001397-nrq4ncdf 543 23 dsRNA dsrna NN cord-001397-nrq4ncdf 543 24 of of IN cord-001397-nrq4ncdf 543 25 TBEV TBEV NNP cord-001397-nrq4ncdf 543 26 have have VBP cord-001397-nrq4ncdf 543 27 been be VBN cord-001397-nrq4ncdf 543 28 described describe VBN cord-001397-nrq4ncdf 543 29 ( ( -LRB- cord-001397-nrq4ncdf 544 1 Overby Overby NNP cord-001397-nrq4ncdf 544 2 et et NNP cord-001397-nrq4ncdf 544 3 al al NNP cord-001397-nrq4ncdf 544 4 . . NNP cord-001397-nrq4ncdf 544 5 , , , cord-001397-nrq4ncdf 544 6 2010 2010 CD cord-001397-nrq4ncdf 544 7 ) ) -RRB- cord-001397-nrq4ncdf 544 8 . . . cord-001397-nrq4ncdf 545 1 As as IN cord-001397-nrq4ncdf 545 2 the the DT cord-001397-nrq4ncdf 545 3 delayed delay VBN cord-001397-nrq4ncdf 545 4 recognition recognition NN cord-001397-nrq4ncdf 545 5 of of IN cord-001397-nrq4ncdf 545 6 viral viral JJ cord-001397-nrq4ncdf 545 7 pathogen pathogen NN cord-001397-nrq4ncdf 545 8 - - HYPH cord-001397-nrq4ncdf 545 9 associated associate VBN cord-001397-nrq4ncdf 545 10 molecular molecular JJ cord-001397-nrq4ncdf 545 11 patterns pattern NNS cord-001397-nrq4ncdf 545 12 is be VBZ cord-001397-nrq4ncdf 545 13 only only RB cord-001397-nrq4ncdf 545 14 temporary temporary JJ cord-001397-nrq4ncdf 545 15 , , , cord-001397-nrq4ncdf 545 16 these these DT cord-001397-nrq4ncdf 545 17 manipulations manipulation NNS cord-001397-nrq4ncdf 545 18 are be VBP cord-001397-nrq4ncdf 545 19 probably probably RB cord-001397-nrq4ncdf 545 20 just just RB cord-001397-nrq4ncdf 545 21 among among IN cord-001397-nrq4ncdf 545 22 the the DT cord-001397-nrq4ncdf 545 23 suite suite NN cord-001397-nrq4ncdf 545 24 of of IN cord-001397-nrq4ncdf 545 25 mechanisms mechanism NNS cord-001397-nrq4ncdf 545 26 deployed deploy VBN cord-001397-nrq4ncdf 545 27 for for IN cord-001397-nrq4ncdf 545 28 the the DT cord-001397-nrq4ncdf 545 29 establishment establishment NN cord-001397-nrq4ncdf 545 30 of of IN cord-001397-nrq4ncdf 545 31 viral viral JJ cord-001397-nrq4ncdf 545 32 persistence persistence NN cord-001397-nrq4ncdf 545 33 . . . cord-001397-nrq4ncdf 546 1 The the DT cord-001397-nrq4ncdf 546 2 specific specific JJ cord-001397-nrq4ncdf 546 3 viral viral JJ cord-001397-nrq4ncdf 546 4 genes gene NNS cord-001397-nrq4ncdf 546 5 and and CC cord-001397-nrq4ncdf 546 6 how how WRB cord-001397-nrq4ncdf 546 7 they -PRON- PRP cord-001397-nrq4ncdf 546 8 manipulate manipulate VBP cord-001397-nrq4ncdf 546 9 apoptosis apoptosis NN cord-001397-nrq4ncdf 546 10 at at IN cord-001397-nrq4ncdf 546 11 a a DT cord-001397-nrq4ncdf 546 12 cellular cellular JJ cord-001397-nrq4ncdf 546 13 level level NN cord-001397-nrq4ncdf 546 14 needs need VBZ cord-001397-nrq4ncdf 546 15 further further JJ cord-001397-nrq4ncdf 546 16 examination examination NN cord-001397-nrq4ncdf 546 17 . . . cord-001397-nrq4ncdf 547 1 Specific specific JJ cord-001397-nrq4ncdf 547 2 host host NN cord-001397-nrq4ncdf 547 3 genes gene NNS cord-001397-nrq4ncdf 547 4 that that WDT cord-001397-nrq4ncdf 547 5 may may MD cord-001397-nrq4ncdf 547 6 contribute contribute VB cord-001397-nrq4ncdf 547 7 toward toward IN cord-001397-nrq4ncdf 547 8 the the DT cord-001397-nrq4ncdf 547 9 development development NN cord-001397-nrq4ncdf 547 10 of of IN cord-001397-nrq4ncdf 547 11 flavivirus flavivirus JJ cord-001397-nrq4ncdf 547 12 persistence persistence NN cord-001397-nrq4ncdf 547 13 in in IN cord-001397-nrq4ncdf 547 14 the the DT cord-001397-nrq4ncdf 547 15 vertebrate vertebrate JJ cord-001397-nrq4ncdf 547 16 host host NN cord-001397-nrq4ncdf 547 17 have have VBP cord-001397-nrq4ncdf 547 18 not not RB cord-001397-nrq4ncdf 547 19 been be VBN cord-001397-nrq4ncdf 547 20 defined define VBN cord-001397-nrq4ncdf 547 21 , , , cord-001397-nrq4ncdf 547 22 but but CC cord-001397-nrq4ncdf 547 23 there there EX cord-001397-nrq4ncdf 547 24 are be VBP cord-001397-nrq4ncdf 547 25 some some DT cord-001397-nrq4ncdf 547 26 suggestions suggestion NNS cord-001397-nrq4ncdf 547 27 . . . cord-001397-nrq4ncdf 548 1 For for IN cord-001397-nrq4ncdf 548 2 instance instance NN cord-001397-nrq4ncdf 548 3 , , , cord-001397-nrq4ncdf 548 4 the the DT cord-001397-nrq4ncdf 548 5 overexpression overexpression NN cord-001397-nrq4ncdf 548 6 of of IN cord-001397-nrq4ncdf 548 7 the the DT cord-001397-nrq4ncdf 548 8 proto proto JJ cord-001397-nrq4ncdf 548 9 - - HYPH cord-001397-nrq4ncdf 548 10 oncogene oncogene NN cord-001397-nrq4ncdf 548 11 Bcl-2 Bcl-2 NNP cord-001397-nrq4ncdf 548 12 was be VBD cord-001397-nrq4ncdf 548 13 reported report VBN cord-001397-nrq4ncdf 548 14 to to TO cord-001397-nrq4ncdf 548 15 prevent prevent VB cord-001397-nrq4ncdf 548 16 apoptosis apoptosis NN cord-001397-nrq4ncdf 548 17 and and CC cord-001397-nrq4ncdf 548 18 promote promote VB cord-001397-nrq4ncdf 548 19 persistence persistence NN cord-001397-nrq4ncdf 548 20 in in IN cord-001397-nrq4ncdf 548 21 JEV JEV NNP cord-001397-nrq4ncdf 548 22 - - HYPH cord-001397-nrq4ncdf 548 23 infected infect VBN cord-001397-nrq4ncdf 548 24 BHK BHK NNP cord-001397-nrq4ncdf 548 25 and and CC cord-001397-nrq4ncdf 548 26 CHO CHO NNP cord-001397-nrq4ncdf 548 27 cells cell NNS cord-001397-nrq4ncdf 548 28 ( ( -LRB- cord-001397-nrq4ncdf 548 29 Liao Liao NNP cord-001397-nrq4ncdf 548 30 et et NNP cord-001397-nrq4ncdf 548 31 al al NNP cord-001397-nrq4ncdf 548 32 . . NNP cord-001397-nrq4ncdf 548 33 , , , cord-001397-nrq4ncdf 548 34 1998 1998 CD cord-001397-nrq4ncdf 548 35 ) ) -RRB- cord-001397-nrq4ncdf 548 36 , , , cord-001397-nrq4ncdf 548 37 suggesting suggest VBG cord-001397-nrq4ncdf 548 38 that that IN cord-001397-nrq4ncdf 548 39 the the DT cord-001397-nrq4ncdf 548 40 control control NN cord-001397-nrq4ncdf 548 41 of of IN cord-001397-nrq4ncdf 548 42 apoptosis apoptosis NN cord-001397-nrq4ncdf 548 43 is be VBZ cord-001397-nrq4ncdf 548 44 likely likely JJ cord-001397-nrq4ncdf 548 45 to to TO cord-001397-nrq4ncdf 548 46 be be VB cord-001397-nrq4ncdf 548 47 implicated implicate VBN cord-001397-nrq4ncdf 548 48 . . . cord-001397-nrq4ncdf 549 1 In in IN cord-001397-nrq4ncdf 549 2 addition addition NN cord-001397-nrq4ncdf 549 3 , , , cord-001397-nrq4ncdf 549 4 some some DT cord-001397-nrq4ncdf 549 5 inbred inbred JJ cord-001397-nrq4ncdf 549 6 laboratory laboratory NN cord-001397-nrq4ncdf 549 7 mice mice NN cord-001397-nrq4ncdf 549 8 strains strain NNS cord-001397-nrq4ncdf 549 9 can can MD cord-001397-nrq4ncdf 549 10 carry carry VB cord-001397-nrq4ncdf 549 11 the the DT cord-001397-nrq4ncdf 549 12 2 2 CD cord-001397-nrq4ncdf 549 13 0 0 CD cord-001397-nrq4ncdf 549 14 -5 -5 CD cord-001397-nrq4ncdf 549 15 0 0 CD cord-001397-nrq4ncdf 549 16 -oligoadenylate -oligoadenylate HYPH cord-001397-nrq4ncdf 549 17 synthetase synthetase NN cord-001397-nrq4ncdf 549 18 gene gene NN cord-001397-nrq4ncdf 549 19 , , , cord-001397-nrq4ncdf 549 20 Flv Flv NNP cord-001397-nrq4ncdf 549 21 r r NNP cord-001397-nrq4ncdf 549 22 , , , cord-001397-nrq4ncdf 549 23 which which WDT cord-001397-nrq4ncdf 549 24 confers confer VBZ cord-001397-nrq4ncdf 549 25 flavivirus flavivirus JJ cord-001397-nrq4ncdf 549 26 resistance resistance NN cord-001397-nrq4ncdf 549 27 ( ( -LRB- cord-001397-nrq4ncdf 549 28 Urosevic Urosevic NNP cord-001397-nrq4ncdf 549 29 et et NNP cord-001397-nrq4ncdf 549 30 al al NNP cord-001397-nrq4ncdf 549 31 . . NNP cord-001397-nrq4ncdf 549 32 , , , cord-001397-nrq4ncdf 549 33 1997 1997 CD cord-001397-nrq4ncdf 549 34 ) ) -RRB- cord-001397-nrq4ncdf 549 35 . . . cord-001397-nrq4ncdf 550 1 The the DT cord-001397-nrq4ncdf 550 2 animals animal NNS cord-001397-nrq4ncdf 550 3 are be VBP cord-001397-nrq4ncdf 550 4 productively productively RB cord-001397-nrq4ncdf 550 5 infected infect VBN cord-001397-nrq4ncdf 550 6 with with IN cord-001397-nrq4ncdf 550 7 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 550 8 , , , cord-001397-nrq4ncdf 550 9 but but CC cord-001397-nrq4ncdf 550 10 produce produce VB cord-001397-nrq4ncdf 550 11 low low JJ cord-001397-nrq4ncdf 550 12 virus virus NN cord-001397-nrq4ncdf 550 13 titer titer NN cord-001397-nrq4ncdf 550 14 ( ( -LRB- cord-001397-nrq4ncdf 550 15 Brinton Brinton NNP cord-001397-nrq4ncdf 550 16 & & CC cord-001397-nrq4ncdf 550 17 Perelygin Perelygin NNP cord-001397-nrq4ncdf 550 18 , , , cord-001397-nrq4ncdf 550 19 2003 2003 CD cord-001397-nrq4ncdf 550 20 ; ; : cord-001397-nrq4ncdf 550 21 Barkhash Barkhash NNP cord-001397-nrq4ncdf 550 22 et et NNP cord-001397-nrq4ncdf 550 23 al al NNP cord-001397-nrq4ncdf 550 24 . . NNP cord-001397-nrq4ncdf 550 25 , , , cord-001397-nrq4ncdf 550 26 2010 2010 CD cord-001397-nrq4ncdf 550 27 ) ) -RRB- cord-001397-nrq4ncdf 550 28 . . . cord-001397-nrq4ncdf 551 1 Mice mouse NNS cord-001397-nrq4ncdf 551 2 that that WDT cord-001397-nrq4ncdf 551 3 are be VBP cord-001397-nrq4ncdf 551 4 susceptible susceptible JJ cord-001397-nrq4ncdf 551 5 to to IN cord-001397-nrq4ncdf 551 6 flavivirus flavivirus JJ cord-001397-nrq4ncdf 551 7 infection infection NN cord-001397-nrq4ncdf 551 8 carry carry VBP cord-001397-nrq4ncdf 551 9 the the DT cord-001397-nrq4ncdf 551 10 Flv Flv NNP cord-001397-nrq4ncdf 551 11 s s POS cord-001397-nrq4ncdf 551 12 allele allele NN cord-001397-nrq4ncdf 551 13 . . . cord-001397-nrq4ncdf 552 1 The the DT cord-001397-nrq4ncdf 552 2 Flv Flv NNP cord-001397-nrq4ncdf 552 3 r r NN cord-001397-nrq4ncdf 552 4 -like -like NN cord-001397-nrq4ncdf 552 5 allele allele NN cord-001397-nrq4ncdf 552 6 has have VBZ cord-001397-nrq4ncdf 552 7 also also RB cord-001397-nrq4ncdf 552 8 been be VBN cord-001397-nrq4ncdf 552 9 characterized characterize VBN cord-001397-nrq4ncdf 552 10 in in IN cord-001397-nrq4ncdf 552 11 wild wild JJ cord-001397-nrq4ncdf 552 12 mice mouse NNS cord-001397-nrq4ncdf 552 13 and and CC cord-001397-nrq4ncdf 552 14 could could MD cord-001397-nrq4ncdf 552 15 be be VB cord-001397-nrq4ncdf 552 16 a a DT cord-001397-nrq4ncdf 552 17 partial partial JJ cord-001397-nrq4ncdf 552 18 explanation explanation NN cord-001397-nrq4ncdf 552 19 of of IN cord-001397-nrq4ncdf 552 20 flavivirus flavivirus JJ cord-001397-nrq4ncdf 552 21 persistence persistence NN cord-001397-nrq4ncdf 552 22 in in IN cord-001397-nrq4ncdf 552 23 rodents rodent NNS cord-001397-nrq4ncdf 552 24 in in IN cord-001397-nrq4ncdf 552 25 nature nature NN cord-001397-nrq4ncdf 552 26 ( ( -LRB- cord-001397-nrq4ncdf 552 27 Urosevic Urosevic NNP cord-001397-nrq4ncdf 552 28 et et NNP cord-001397-nrq4ncdf 552 29 al al NNP cord-001397-nrq4ncdf 552 30 . . NNP cord-001397-nrq4ncdf 552 31 , , , cord-001397-nrq4ncdf 552 32 1997 1997 CD cord-001397-nrq4ncdf 552 33 ) ) -RRB- cord-001397-nrq4ncdf 552 34 . . . cord-001397-nrq4ncdf 553 1 Additional additional JJ cord-001397-nrq4ncdf 553 2 vertebrate vertebrate JJ cord-001397-nrq4ncdf 553 3 genes gene NNS cord-001397-nrq4ncdf 553 4 , , , cord-001397-nrq4ncdf 553 5 apart apart RB cord-001397-nrq4ncdf 553 6 from from IN cord-001397-nrq4ncdf 553 7 the the DT cord-001397-nrq4ncdf 553 8 Flv Flv NNP cord-001397-nrq4ncdf 553 9 , , , cord-001397-nrq4ncdf 553 10 could could MD cord-001397-nrq4ncdf 553 11 play play VB cord-001397-nrq4ncdf 553 12 a a DT cord-001397-nrq4ncdf 553 13 role role NN cord-001397-nrq4ncdf 553 14 in in IN cord-001397-nrq4ncdf 553 15 varied varied JJ cord-001397-nrq4ncdf 553 16 susceptibilities susceptibility NNS cord-001397-nrq4ncdf 553 17 of of IN cord-001397-nrq4ncdf 553 18 different different JJ cord-001397-nrq4ncdf 553 19 mouse mouse NN cord-001397-nrq4ncdf 553 20 strains strain NNS cord-001397-nrq4ncdf 553 21 to to TO cord-001397-nrq4ncdf 553 22 flavivirus flavivirus JJ cord-001397-nrq4ncdf 553 23 infection infection NN cord-001397-nrq4ncdf 553 24 . . . cord-001397-nrq4ncdf 554 1 This this DT cord-001397-nrq4ncdf 554 2 was be VBD cord-001397-nrq4ncdf 554 3 suggested suggest VBN cord-001397-nrq4ncdf 554 4 from from IN cord-001397-nrq4ncdf 554 5 recent recent JJ cord-001397-nrq4ncdf 554 6 observations observation NNS cord-001397-nrq4ncdf 554 7 that that IN cord-001397-nrq4ncdf 554 8 TBEV TBEV NNP cord-001397-nrq4ncdf 554 9 - - HYPH cord-001397-nrq4ncdf 554 10 infected infect VBN cord-001397-nrq4ncdf 554 11 BALBc BALBc NNS cord-001397-nrq4ncdf 554 12 mice mouse NNS cord-001397-nrq4ncdf 554 13 were be VBD cord-001397-nrq4ncdf 554 14 moderately moderately RB cord-001397-nrq4ncdf 554 15 resistant resistant JJ cord-001397-nrq4ncdf 554 16 , , , cord-001397-nrq4ncdf 554 17 STS STS NNP cord-001397-nrq4ncdf 554 18 mice mouse NNS cord-001397-nrq4ncdf 554 19 are be VBP cord-001397-nrq4ncdf 554 20 highly highly RB cord-001397-nrq4ncdf 554 21 resistant resistant JJ cord-001397-nrq4ncdf 554 22 , , , cord-001397-nrq4ncdf 554 23 whereas whereas IN cord-001397-nrq4ncdf 554 24 the the DT cord-001397-nrq4ncdf 554 25 BALBc BALBc NNPS cord-001397-nrq4ncdf 554 26 / / SYM cord-001397-nrq4ncdf 554 27 STS sts NN cord-001397-nrq4ncdf 554 28 recombinant recombinant JJ cord-001397-nrq4ncdf 554 29 mice mouse NNS cord-001397-nrq4ncdf 554 30 were be VBD cord-001397-nrq4ncdf 554 31 highly highly RB cord-001397-nrq4ncdf 554 32 sensitive sensitive JJ cord-001397-nrq4ncdf 554 33 to to IN cord-001397-nrq4ncdf 554 34 infection infection NN cord-001397-nrq4ncdf 555 1 ( ( -LRB- cord-001397-nrq4ncdf 555 2 Palus Palus NNP cord-001397-nrq4ncdf 555 3 et et NNP cord-001397-nrq4ncdf 555 4 al al NNP cord-001397-nrq4ncdf 555 5 . . NNP cord-001397-nrq4ncdf 555 6 , , , cord-001397-nrq4ncdf 555 7 2013 2013 CD cord-001397-nrq4ncdf 555 8 ) ) -RRB- cord-001397-nrq4ncdf 555 9 . . . cord-001397-nrq4ncdf 556 1 Immunosuppression Immunosuppression NNP cord-001397-nrq4ncdf 556 2 may may MD cord-001397-nrq4ncdf 556 3 also also RB cord-001397-nrq4ncdf 556 4 be be VB cord-001397-nrq4ncdf 556 5 a a DT cord-001397-nrq4ncdf 556 6 potentiating potentiate VBG cord-001397-nrq4ncdf 556 7 factor factor NN cord-001397-nrq4ncdf 556 8 for for IN cord-001397-nrq4ncdf 556 9 the the DT cord-001397-nrq4ncdf 556 10 establishment establishment NN cord-001397-nrq4ncdf 556 11 of of IN cord-001397-nrq4ncdf 556 12 flavivirus flavivirus JJ cord-001397-nrq4ncdf 556 13 persistence persistence NN cord-001397-nrq4ncdf 556 14 in in IN cord-001397-nrq4ncdf 556 15 animal animal NN cord-001397-nrq4ncdf 556 16 hosts host NNS cord-001397-nrq4ncdf 556 17 . . . cord-001397-nrq4ncdf 557 1 For for IN cord-001397-nrq4ncdf 557 2 example example NN cord-001397-nrq4ncdf 557 3 , , , cord-001397-nrq4ncdf 557 4 WNV WNV NNP cord-001397-nrq4ncdf 557 5 persistence persistence NN cord-001397-nrq4ncdf 557 6 was be VBD cord-001397-nrq4ncdf 557 7 demonstrated demonstrate VBN cord-001397-nrq4ncdf 557 8 by by IN cord-001397-nrq4ncdf 557 9 the the DT cord-001397-nrq4ncdf 557 10 detection detection NN cord-001397-nrq4ncdf 557 11 of of IN cord-001397-nrq4ncdf 557 12 WNV WNV NNP cord-001397-nrq4ncdf 557 13 RNA RNA NNP cord-001397-nrq4ncdf 557 14 and and CC cord-001397-nrq4ncdf 557 15 immunohistochemistry immunohistochemistry NN cord-001397-nrq4ncdf 557 16 in in IN cord-001397-nrq4ncdf 557 17 brain brain NN cord-001397-nrq4ncdf 557 18 tissue tissue NN cord-001397-nrq4ncdf 557 19 of of IN cord-001397-nrq4ncdf 557 20 an an DT cord-001397-nrq4ncdf 557 21 immunosuppressed immunosuppressed JJ cord-001397-nrq4ncdf 557 22 57-year 57-year JJ cord-001397-nrq4ncdf 557 23 - - HYPH cord-001397-nrq4ncdf 557 24 old old JJ cord-001397-nrq4ncdf 557 25 man man NN cord-001397-nrq4ncdf 557 26 4 4 CD cord-001397-nrq4ncdf 557 27 months month NNS cord-001397-nrq4ncdf 557 28 after after IN cord-001397-nrq4ncdf 557 29 the the DT cord-001397-nrq4ncdf 557 30 initial initial JJ cord-001397-nrq4ncdf 557 31 diagnosis diagnosis NN cord-001397-nrq4ncdf 557 32 ( ( -LRB- cord-001397-nrq4ncdf 557 33 Penn Penn NNP cord-001397-nrq4ncdf 557 34 et et NNP cord-001397-nrq4ncdf 557 35 al al NNP cord-001397-nrq4ncdf 557 36 . . NNP cord-001397-nrq4ncdf 557 37 , , , cord-001397-nrq4ncdf 557 38 2006 2006 CD cord-001397-nrq4ncdf 557 39 ) ) -RRB- cord-001397-nrq4ncdf 557 40 . . . cord-001397-nrq4ncdf 558 1 The the DT cord-001397-nrq4ncdf 558 2 follicular follicular JJ cord-001397-nrq4ncdf 558 3 B b NN cord-001397-nrq4ncdf 558 4 cell cell NN cord-001397-nrq4ncdf 558 5 lymphoma lymphoma NN cord-001397-nrq4ncdf 558 6 , , , cord-001397-nrq4ncdf 558 7 from from IN cord-001397-nrq4ncdf 558 8 which which WDT cord-001397-nrq4ncdf 558 9 he -PRON- PRP cord-001397-nrq4ncdf 558 10 had have VBD cord-001397-nrq4ncdf 558 11 suffered suffer VBN cord-001397-nrq4ncdf 558 12 , , , cord-001397-nrq4ncdf 558 13 may may MD cord-001397-nrq4ncdf 558 14 have have VB cord-001397-nrq4ncdf 558 15 facilitated facilitate VBN cord-001397-nrq4ncdf 558 16 , , , cord-001397-nrq4ncdf 558 17 or or CC cord-001397-nrq4ncdf 558 18 aggravated aggravate VBN cord-001397-nrq4ncdf 558 19 , , , cord-001397-nrq4ncdf 558 20 the the DT cord-001397-nrq4ncdf 558 21 persistence persistence NN cord-001397-nrq4ncdf 558 22 of of IN cord-001397-nrq4ncdf 558 23 WNV WNV NNP cord-001397-nrq4ncdf 558 24 . . . cord-001397-nrq4ncdf 559 1 In in IN cord-001397-nrq4ncdf 559 2 mice mouse NNS cord-001397-nrq4ncdf 559 3 , , , cord-001397-nrq4ncdf 559 4 transient transient JJ cord-001397-nrq4ncdf 559 5 immunosuppression immunosuppression NN cord-001397-nrq4ncdf 559 6 with with IN cord-001397-nrq4ncdf 559 7 cyclophosphamide cyclophosphamide NN cord-001397-nrq4ncdf 559 8 leads lead VBZ cord-001397-nrq4ncdf 559 9 to to IN cord-001397-nrq4ncdf 559 10 WNV WNV NNP cord-001397-nrq4ncdf 559 11 recrudescence recrudescence NNP cord-001397-nrq4ncdf 560 1 ( ( -LRB- cord-001397-nrq4ncdf 560 2 Appler Appler NNP cord-001397-nrq4ncdf 560 3 et et NNP cord-001397-nrq4ncdf 560 4 al al NNP cord-001397-nrq4ncdf 560 5 . . NNP cord-001397-nrq4ncdf 560 6 , , , cord-001397-nrq4ncdf 560 7 2010 2010 CD cord-001397-nrq4ncdf 560 8 ) ) -RRB- cord-001397-nrq4ncdf 560 9 , , , cord-001397-nrq4ncdf 560 10 an an DT cord-001397-nrq4ncdf 560 11 observation observation NN cord-001397-nrq4ncdf 560 12 suggesting suggest VBG cord-001397-nrq4ncdf 560 13 that that IN cord-001397-nrq4ncdf 560 14 some some DT cord-001397-nrq4ncdf 560 15 aspects aspect NNS cord-001397-nrq4ncdf 560 16 of of IN cord-001397-nrq4ncdf 560 17 the the DT cord-001397-nrq4ncdf 560 18 immune immune JJ cord-001397-nrq4ncdf 560 19 system system NN cord-001397-nrq4ncdf 560 20 operate operate VBP cord-001397-nrq4ncdf 560 21 to to TO cord-001397-nrq4ncdf 560 22 restrict restrict VB cord-001397-nrq4ncdf 560 23 WNV WNV NNP cord-001397-nrq4ncdf 560 24 replication replication NN cord-001397-nrq4ncdf 560 25 during during IN cord-001397-nrq4ncdf 560 26 persistence persistence NN cord-001397-nrq4ncdf 560 27 . . . cord-001397-nrq4ncdf 561 1 However however RB cord-001397-nrq4ncdf 561 2 , , , cord-001397-nrq4ncdf 561 3 the the DT cord-001397-nrq4ncdf 561 4 situation situation NN cord-001397-nrq4ncdf 561 5 is be VBZ cord-001397-nrq4ncdf 561 6 complicated complicated JJ cord-001397-nrq4ncdf 561 7 because because IN cord-001397-nrq4ncdf 561 8 WNV WNV NNP cord-001397-nrq4ncdf 561 9 is be VBZ cord-001397-nrq4ncdf 561 10 able able JJ cord-001397-nrq4ncdf 561 11 to to TO cord-001397-nrq4ncdf 561 12 persist persist VB cord-001397-nrq4ncdf 561 13 for for IN cord-001397-nrq4ncdf 561 14 up up IN cord-001397-nrq4ncdf 561 15 to to TO cord-001397-nrq4ncdf 561 16 16 16 CD cord-001397-nrq4ncdf 561 17 months month NNS cord-001397-nrq4ncdf 561 18 in in IN cord-001397-nrq4ncdf 561 19 the the DT cord-001397-nrq4ncdf 561 20 face face NN cord-001397-nrq4ncdf 561 21 of of IN cord-001397-nrq4ncdf 561 22 a a DT cord-001397-nrq4ncdf 561 23 robust robust JJ cord-001397-nrq4ncdf 561 24 humoral humoral JJ cord-001397-nrq4ncdf 561 25 immune immune JJ cord-001397-nrq4ncdf 561 26 response response NN cord-001397-nrq4ncdf 561 27 in in IN cord-001397-nrq4ncdf 561 28 C57BL/6 C57BL/6 NNP cord-001397-nrq4ncdf 561 29 mice mouse NNS cord-001397-nrq4ncdf 561 30 ( ( -LRB- cord-001397-nrq4ncdf 561 31 Appler Appler NNP cord-001397-nrq4ncdf 561 32 et et NNP cord-001397-nrq4ncdf 561 33 al al NNP cord-001397-nrq4ncdf 561 34 . . NNP cord-001397-nrq4ncdf 561 35 , , , cord-001397-nrq4ncdf 561 36 2010 2010 CD cord-001397-nrq4ncdf 561 37 ) ) -RRB- cord-001397-nrq4ncdf 561 38 . . . cord-001397-nrq4ncdf 562 1 Furthermore furthermore RB cord-001397-nrq4ncdf 562 2 , , , cord-001397-nrq4ncdf 562 3 WNV WNV NNP cord-001397-nrq4ncdf 562 4 persistence persistence NN cord-001397-nrq4ncdf 562 5 was be VBD cord-001397-nrq4ncdf 562 6 reported report VBN cord-001397-nrq4ncdf 562 7 in in IN cord-001397-nrq4ncdf 562 8 the the DT cord-001397-nrq4ncdf 562 9 brains brain NNS cord-001397-nrq4ncdf 562 10 of of IN cord-001397-nrq4ncdf 562 11 CD8 CD8 NNP cord-001397-nrq4ncdf 562 12 + + CC cord-001397-nrq4ncdf 562 13 T T NNP cord-001397-nrq4ncdf 562 14 cell cell NN cord-001397-nrq4ncdf 562 15 - - HYPH cord-001397-nrq4ncdf 562 16 deficient deficient JJ cord-001397-nrq4ncdf 562 17 rodents rodent NNS cord-001397-nrq4ncdf 562 18 ( ( -LRB- cord-001397-nrq4ncdf 562 19 Shrestha Shrestha NNP cord-001397-nrq4ncdf 562 20 & & CC cord-001397-nrq4ncdf 562 21 Diamond Diamond NNP cord-001397-nrq4ncdf 562 22 , , , cord-001397-nrq4ncdf 562 23 2004 2004 CD cord-001397-nrq4ncdf 562 24 ) ) -RRB- cord-001397-nrq4ncdf 562 25 , , , cord-001397-nrq4ncdf 562 26 but but CC cord-001397-nrq4ncdf 562 27 the the DT cord-001397-nrq4ncdf 562 28 CD8 CD8 NNP cord-001397-nrq4ncdf 562 29 + + CC cord-001397-nrq4ncdf 562 30 T T NNP cord-001397-nrq4ncdf 562 31 cell cell NN cord-001397-nrq4ncdf 562 32 deficiency deficiency NN cord-001397-nrq4ncdf 562 33 did do VBD cord-001397-nrq4ncdf 562 34 not not RB cord-001397-nrq4ncdf 562 35 affect affect VB cord-001397-nrq4ncdf 562 36 the the DT cord-001397-nrq4ncdf 562 37 antibody antibody NN cord-001397-nrq4ncdf 562 38 response response NN cord-001397-nrq4ncdf 562 39 in in IN cord-001397-nrq4ncdf 562 40 this this DT cord-001397-nrq4ncdf 562 41 mouse mouse NN cord-001397-nrq4ncdf 562 42 model model NN cord-001397-nrq4ncdf 562 43 . . . cord-001397-nrq4ncdf 563 1 Knowledge knowledge NN cord-001397-nrq4ncdf 563 2 about about IN cord-001397-nrq4ncdf 563 3 specific specific JJ cord-001397-nrq4ncdf 563 4 immune immune JJ cord-001397-nrq4ncdf 563 5 system system NN cord-001397-nrq4ncdf 563 6 components component NNS cord-001397-nrq4ncdf 563 7 that that WDT cord-001397-nrq4ncdf 563 8 could could MD cord-001397-nrq4ncdf 563 9 facilitate facilitate VB cord-001397-nrq4ncdf 563 10 or or CC cord-001397-nrq4ncdf 563 11 control control VB cord-001397-nrq4ncdf 563 12 viral viral JJ cord-001397-nrq4ncdf 563 13 persistence persistence NN cord-001397-nrq4ncdf 563 14 remains remain VBZ cord-001397-nrq4ncdf 563 15 to to TO cord-001397-nrq4ncdf 563 16 be be VB cord-001397-nrq4ncdf 563 17 characterized characterize VBN cord-001397-nrq4ncdf 563 18 . . . cord-001397-nrq4ncdf 564 1 Infection infection NN cord-001397-nrq4ncdf 564 2 by by IN cord-001397-nrq4ncdf 564 3 VBFVs vbfv NNS cord-001397-nrq4ncdf 564 4 of of IN cord-001397-nrq4ncdf 564 5 arthropod arthropod JJ cord-001397-nrq4ncdf 564 6 cells cell NNS cord-001397-nrq4ncdf 564 7 has have VBZ cord-001397-nrq4ncdf 564 8 not not RB cord-001397-nrq4ncdf 564 9 received receive VBN cord-001397-nrq4ncdf 564 10 the the DT cord-001397-nrq4ncdf 564 11 same same JJ cord-001397-nrq4ncdf 564 12 degree degree NN cord-001397-nrq4ncdf 564 13 of of IN cord-001397-nrq4ncdf 564 14 study study NN cord-001397-nrq4ncdf 564 15 ; ; : cord-001397-nrq4ncdf 564 16 however however RB cord-001397-nrq4ncdf 564 17 , , , cord-001397-nrq4ncdf 564 18 acute acute JJ cord-001397-nrq4ncdf 564 19 infection infection NN cord-001397-nrq4ncdf 564 20 is be VBZ cord-001397-nrq4ncdf 564 21 not not RB cord-001397-nrq4ncdf 564 22 accompanied accompany VBN cord-001397-nrq4ncdf 564 23 by by IN cord-001397-nrq4ncdf 564 24 the the DT cord-001397-nrq4ncdf 564 25 same same JJ cord-001397-nrq4ncdf 564 26 cytopathic cytopathic JJ cord-001397-nrq4ncdf 564 27 response response NN cord-001397-nrq4ncdf 564 28 observed observe VBN cord-001397-nrq4ncdf 564 29 in in IN cord-001397-nrq4ncdf 564 30 mammalian mammalian JJ cord-001397-nrq4ncdf 564 31 cells cell NNS cord-001397-nrq4ncdf 564 32 . . . cord-001397-nrq4ncdf 565 1 In in IN cord-001397-nrq4ncdf 565 2 addition addition NN cord-001397-nrq4ncdf 565 3 , , , cord-001397-nrq4ncdf 565 4 very very RB cord-001397-nrq4ncdf 565 5 little little JJ cord-001397-nrq4ncdf 565 6 is be VBZ cord-001397-nrq4ncdf 565 7 known know VBN cord-001397-nrq4ncdf 565 8 about about IN cord-001397-nrq4ncdf 565 9 how how WRB cord-001397-nrq4ncdf 565 10 or or CC cord-001397-nrq4ncdf 565 11 in in IN cord-001397-nrq4ncdf 565 12 what what WP cord-001397-nrq4ncdf 565 13 tissues tissue NNS cord-001397-nrq4ncdf 565 14 TBFVs tbfvs VBP cord-001397-nrq4ncdf 565 15 persist persist VB cord-001397-nrq4ncdf 565 16 in in IN cord-001397-nrq4ncdf 565 17 the the DT cord-001397-nrq4ncdf 565 18 ticks tick NNS cord-001397-nrq4ncdf 565 19 , , , cord-001397-nrq4ncdf 565 20 but but CC cord-001397-nrq4ncdf 565 21 the the DT cord-001397-nrq4ncdf 565 22 viruses virus NNS cord-001397-nrq4ncdf 565 23 likely likely RB cord-001397-nrq4ncdf 565 24 evolved evolve VBN cord-001397-nrq4ncdf 565 25 mechanisms mechanism NNS cord-001397-nrq4ncdf 565 26 of of IN cord-001397-nrq4ncdf 565 27 modulating modulate VBG cord-001397-nrq4ncdf 565 28 or or CC cord-001397-nrq4ncdf 565 29 evading evade VBG cord-001397-nrq4ncdf 565 30 the the DT cord-001397-nrq4ncdf 565 31 tick tick NN cord-001397-nrq4ncdf 565 32 immune immune JJ cord-001397-nrq4ncdf 565 33 system system NN cord-001397-nrq4ncdf 565 34 over over IN cord-001397-nrq4ncdf 565 35 the the DT cord-001397-nrq4ncdf 565 36 millenia millenia NNS cord-001397-nrq4ncdf 565 37 ( ( -LRB- cord-001397-nrq4ncdf 565 38 Robertson Robertson NNP cord-001397-nrq4ncdf 565 39 et et NNP cord-001397-nrq4ncdf 565 40 al al NNP cord-001397-nrq4ncdf 565 41 . . NNP cord-001397-nrq4ncdf 565 42 , , , cord-001397-nrq4ncdf 565 43 2009 2009 CD cord-001397-nrq4ncdf 565 44 ) ) -RRB- cord-001397-nrq4ncdf 565 45 . . . cord-001397-nrq4ncdf 566 1 Persistent persistent JJ cord-001397-nrq4ncdf 566 2 infection infection NN cord-001397-nrq4ncdf 566 3 of of IN cord-001397-nrq4ncdf 566 4 the the DT cord-001397-nrq4ncdf 566 5 I. I. NNP cord-001397-nrq4ncdf 566 6 scapularis scapularis NNP cord-001397-nrq4ncdf 566 7 cell cell NN cord-001397-nrq4ncdf 566 8 line line NN cord-001397-nrq4ncdf 566 9 ISE-6 ISE-6 NNP cord-001397-nrq4ncdf 567 1 ( ( -LRB- cord-001397-nrq4ncdf 567 2 Munderloh Munderloh NNP cord-001397-nrq4ncdf 567 3 et et NNP cord-001397-nrq4ncdf 567 4 al al NNP cord-001397-nrq4ncdf 567 5 . . NNP cord-001397-nrq4ncdf 567 6 , , , cord-001397-nrq4ncdf 567 7 1994 1994 CD cord-001397-nrq4ncdf 567 8 ) ) -RRB- cord-001397-nrq4ncdf 567 9 was be VBD cord-001397-nrq4ncdf 567 10 readily readily RB cord-001397-nrq4ncdf 567 11 established establish VBN cord-001397-nrq4ncdf 567 12 and and CC cord-001397-nrq4ncdf 567 13 was be VBD cord-001397-nrq4ncdf 567 14 noncytopathic noncytopathic JJ cord-001397-nrq4ncdf 567 15 ( ( -LRB- cord-001397-nrq4ncdf 567 16 Offerdahl Offerdahl NNP cord-001397-nrq4ncdf 567 17 et et NNP cord-001397-nrq4ncdf 567 18 al al NNP cord-001397-nrq4ncdf 567 19 . . NNP cord-001397-nrq4ncdf 567 20 , , , cord-001397-nrq4ncdf 567 21 2012 2012 CD cord-001397-nrq4ncdf 567 22 ) ) -RRB- cord-001397-nrq4ncdf 567 23 . . . cord-001397-nrq4ncdf 568 1 Detailed detailed JJ cord-001397-nrq4ncdf 568 2 studies study NNS cord-001397-nrq4ncdf 568 3 of of IN cord-001397-nrq4ncdf 568 4 persistent persistent JJ cord-001397-nrq4ncdf 568 5 TBFV TBFV NNP cord-001397-nrq4ncdf 568 6 infection infection NN cord-001397-nrq4ncdf 568 7 in in IN cord-001397-nrq4ncdf 568 8 arthropod arthropod JJ cord-001397-nrq4ncdf 568 9 cell cell NN cord-001397-nrq4ncdf 568 10 lines line NNS cord-001397-nrq4ncdf 568 11 using use VBG cord-001397-nrq4ncdf 568 12 contemporary contemporary JJ cord-001397-nrq4ncdf 568 13 techniques technique NNS cord-001397-nrq4ncdf 568 14 and and CC cord-001397-nrq4ncdf 568 15 methods method NNS cord-001397-nrq4ncdf 568 16 are be VBP cord-001397-nrq4ncdf 568 17 certain certain JJ cord-001397-nrq4ncdf 568 18 to to TO cord-001397-nrq4ncdf 568 19 yield yield VB cord-001397-nrq4ncdf 568 20 useful useful JJ cord-001397-nrq4ncdf 568 21 and and CC cord-001397-nrq4ncdf 568 22 interesting interesting JJ cord-001397-nrq4ncdf 568 23 information information NN cord-001397-nrq4ncdf 568 24 . . . cord-001397-nrq4ncdf 569 1 The the DT cord-001397-nrq4ncdf 569 2 mechanism(s mechanism(s NNP cord-001397-nrq4ncdf 569 3 ) ) -RRB- cord-001397-nrq4ncdf 569 4 of of IN cord-001397-nrq4ncdf 569 5 how how WRB cord-001397-nrq4ncdf 569 6 MBFVs mbfv NNS cord-001397-nrq4ncdf 569 7 persist persist VBP cord-001397-nrq4ncdf 569 8 in in IN cord-001397-nrq4ncdf 569 9 mosquitoes mosquito NNS cord-001397-nrq4ncdf 569 10 also also RB cord-001397-nrq4ncdf 569 11 remains remain VBZ cord-001397-nrq4ncdf 569 12 a a DT cord-001397-nrq4ncdf 569 13 suitable suitable JJ cord-001397-nrq4ncdf 569 14 topic topic NN cord-001397-nrq4ncdf 569 15 for for IN cord-001397-nrq4ncdf 569 16 investigation investigation NN cord-001397-nrq4ncdf 569 17 . . . cord-001397-nrq4ncdf 570 1 SLEV SLEV NNP cord-001397-nrq4ncdf 570 2 persists persist VBZ cord-001397-nrq4ncdf 570 3 in in IN cord-001397-nrq4ncdf 570 4 the the DT cord-001397-nrq4ncdf 570 5 midgut midgut NN cord-001397-nrq4ncdf 570 6 of of IN cord-001397-nrq4ncdf 570 7 C. C. NNP cord-001397-nrq4ncdf 570 8 pipiens pipien NNS cord-001397-nrq4ncdf 570 9 for for IN cord-001397-nrq4ncdf 570 10 hours hour NNS cord-001397-nrq4ncdf 570 11 before before IN cord-001397-nrq4ncdf 570 12 infecting infect VBG cord-001397-nrq4ncdf 570 13 the the DT cord-001397-nrq4ncdf 570 14 midgut midgut NN cord-001397-nrq4ncdf 570 15 epithelium epithelium NN cord-001397-nrq4ncdf 570 16 ( ( -LRB- cord-001397-nrq4ncdf 570 17 Whitfield Whitfield NNP cord-001397-nrq4ncdf 570 18 et et NNP cord-001397-nrq4ncdf 570 19 al al NNP cord-001397-nrq4ncdf 570 20 . . . cord-001397-nrq4ncdf 571 1 , , , cord-001397-nrq4ncdf 571 2 1973 1973 CD cord-001397-nrq4ncdf 571 3 ; ; : cord-001397-nrq4ncdf 571 4 Brackney Brackney NNP cord-001397-nrq4ncdf 571 5 et et NNP cord-001397-nrq4ncdf 571 6 al al NNP cord-001397-nrq4ncdf 571 7 . . NNP cord-001397-nrq4ncdf 571 8 , , , cord-001397-nrq4ncdf 571 9 2008a 2008a CD cord-001397-nrq4ncdf 571 10 ) ) -RRB- cord-001397-nrq4ncdf 571 11 , , , cord-001397-nrq4ncdf 571 12 but but CC cord-001397-nrq4ncdf 571 13 this this DT cord-001397-nrq4ncdf 571 14 is be VBZ cord-001397-nrq4ncdf 571 15 a a DT cord-001397-nrq4ncdf 571 16 short short JJ cord-001397-nrq4ncdf 571 17 time time NN cord-001397-nrq4ncdf 571 18 . . . cord-001397-nrq4ncdf 572 1 Interestingly interestingly RB cord-001397-nrq4ncdf 572 2 , , , cord-001397-nrq4ncdf 572 3 approximately approximately RB cord-001397-nrq4ncdf 572 4 two two CD cord-001397-nrq4ncdf 572 5 - - HYPH cord-001397-nrq4ncdf 572 6 thirds third NNS cord-001397-nrq4ncdf 572 7 of of IN cord-001397-nrq4ncdf 572 8 flavivirus flavivirus JJ cord-001397-nrq4ncdf 572 9 - - HYPH cord-001397-nrq4ncdf 572 10 related relate VBN cord-001397-nrq4ncdf 572 11 sequences sequence NNS cord-001397-nrq4ncdf 572 12 were be VBD cord-001397-nrq4ncdf 572 13 reportedly reportedly RB cord-001397-nrq4ncdf 572 14 detected detect VBN cord-001397-nrq4ncdf 572 15 as as IN cord-001397-nrq4ncdf 572 16 integrated integrate VBN cord-001397-nrq4ncdf 572 17 dsDNA dsdna RB cord-001397-nrq4ncdf 572 18 form form NN cord-001397-nrq4ncdf 572 19 in in IN cord-001397-nrq4ncdf 572 20 laboratory laboratory NN cord-001397-nrq4ncdf 572 21 - - HYPH cord-001397-nrq4ncdf 572 22 bred breed VBN cord-001397-nrq4ncdf 572 23 and and CC cord-001397-nrq4ncdf 572 24 wild wild JJ cord-001397-nrq4ncdf 572 25 Aedes Aedes NNP cord-001397-nrq4ncdf 572 26 mosquitoes mosquito NNS cord-001397-nrq4ncdf 572 27 ( ( -LRB- cord-001397-nrq4ncdf 572 28 Crochu Crochu NNP cord-001397-nrq4ncdf 572 29 et et NNP cord-001397-nrq4ncdf 572 30 al al NNP cord-001397-nrq4ncdf 572 31 . . NNP cord-001397-nrq4ncdf 572 32 , , , cord-001397-nrq4ncdf 572 33 2004 2004 CD cord-001397-nrq4ncdf 572 34 ) ) -RRB- cord-001397-nrq4ncdf 572 35 , , , cord-001397-nrq4ncdf 572 36 although although IN cord-001397-nrq4ncdf 572 37 detection detection NN cord-001397-nrq4ncdf 572 38 of of IN cord-001397-nrq4ncdf 572 39 a a DT cord-001397-nrq4ncdf 572 40 complete complete JJ cord-001397-nrq4ncdf 572 41 flavivirus flavivirus JJ cord-001397-nrq4ncdf 572 42 genome genome NN cord-001397-nrq4ncdf 572 43 was be VBD cord-001397-nrq4ncdf 572 44 not not RB cord-001397-nrq4ncdf 572 45 reported report VBN cord-001397-nrq4ncdf 572 46 . . . cord-001397-nrq4ncdf 573 1 Furthermore furthermore RB cord-001397-nrq4ncdf 573 2 , , , cord-001397-nrq4ncdf 573 3 the the DT cord-001397-nrq4ncdf 573 4 finding finding NN cord-001397-nrq4ncdf 573 5 of of IN cord-001397-nrq4ncdf 573 6 partial partial JJ cord-001397-nrq4ncdf 573 7 flavivirus flavivirus JJ cord-001397-nrq4ncdf 573 8 - - HYPH cord-001397-nrq4ncdf 573 9 like like JJ cord-001397-nrq4ncdf 573 10 sequences sequence NNS cord-001397-nrq4ncdf 573 11 in in IN cord-001397-nrq4ncdf 573 12 DNA dna NN cord-001397-nrq4ncdf 573 13 form form NN cord-001397-nrq4ncdf 573 14 is be VBZ cord-001397-nrq4ncdf 573 15 not not RB cord-001397-nrq4ncdf 573 16 clear clear JJ cord-001397-nrq4ncdf 573 17 . . . cord-001397-nrq4ncdf 574 1 Clearly clearly RB cord-001397-nrq4ncdf 574 2 , , , cord-001397-nrq4ncdf 574 3 research research NN cord-001397-nrq4ncdf 574 4 into into IN cord-001397-nrq4ncdf 574 5 the the DT cord-001397-nrq4ncdf 574 6 biology biology NN cord-001397-nrq4ncdf 574 7 of of IN cord-001397-nrq4ncdf 574 8 flavivirus flavivirus JJ cord-001397-nrq4ncdf 574 9 persistence persistence NN cord-001397-nrq4ncdf 574 10 in in IN cord-001397-nrq4ncdf 574 11 mosquitoes mosquito NNS cord-001397-nrq4ncdf 574 12 and and CC cord-001397-nrq4ncdf 574 13 ticks tick NNS cord-001397-nrq4ncdf 574 14 has have VBZ cord-001397-nrq4ncdf 574 15 been be VBN cord-001397-nrq4ncdf 574 16 limited limit VBN cord-001397-nrq4ncdf 574 17 and and CC cord-001397-nrq4ncdf 574 18 is be VBZ cord-001397-nrq4ncdf 574 19 worthy worthy JJ cord-001397-nrq4ncdf 574 20 of of IN cord-001397-nrq4ncdf 574 21 extensive extensive JJ cord-001397-nrq4ncdf 574 22 additional additional JJ cord-001397-nrq4ncdf 574 23 research research NN cord-001397-nrq4ncdf 574 24 . . . cord-001397-nrq4ncdf 575 1 In in IN cord-001397-nrq4ncdf 575 2 summary summary NN cord-001397-nrq4ncdf 575 3 , , , cord-001397-nrq4ncdf 575 4 it -PRON- PRP cord-001397-nrq4ncdf 575 5 should should MD cord-001397-nrq4ncdf 575 6 be be VB cord-001397-nrq4ncdf 575 7 apparent apparent JJ cord-001397-nrq4ncdf 575 8 that that IN cord-001397-nrq4ncdf 575 9 both both CC cord-001397-nrq4ncdf 575 10 viral viral JJ cord-001397-nrq4ncdf 575 11 and and CC cord-001397-nrq4ncdf 575 12 host host NN cord-001397-nrq4ncdf 575 13 factors factor NNS cord-001397-nrq4ncdf 575 14 play play VBP cord-001397-nrq4ncdf 575 15 a a DT cord-001397-nrq4ncdf 575 16 role role NN cord-001397-nrq4ncdf 575 17 in in IN cord-001397-nrq4ncdf 575 18 the the DT cord-001397-nrq4ncdf 575 19 initiation initiation NN cord-001397-nrq4ncdf 575 20 and and CC cord-001397-nrq4ncdf 575 21 maintenance maintenance NN cord-001397-nrq4ncdf 575 22 of of IN cord-001397-nrq4ncdf 575 23 persistent persistent JJ cord-001397-nrq4ncdf 575 24 infection infection NN cord-001397-nrq4ncdf 575 25 at at IN cord-001397-nrq4ncdf 575 26 both both CC cord-001397-nrq4ncdf 575 27 the the DT cord-001397-nrq4ncdf 575 28 cellular cellular JJ cord-001397-nrq4ncdf 575 29 and and CC cord-001397-nrq4ncdf 575 30 organismal organismal JJ cord-001397-nrq4ncdf 575 31 levels level NNS cord-001397-nrq4ncdf 575 32 . . . cord-001397-nrq4ncdf 576 1 In in IN cord-001397-nrq4ncdf 576 2 addition addition NN cord-001397-nrq4ncdf 576 3 , , , cord-001397-nrq4ncdf 576 4 successful successful JJ cord-001397-nrq4ncdf 576 5 persistence persistence NN cord-001397-nrq4ncdf 576 6 in in IN cord-001397-nrq4ncdf 576 7 nature nature NN cord-001397-nrq4ncdf 576 8 almost almost RB cord-001397-nrq4ncdf 576 9 certainly certainly RB cord-001397-nrq4ncdf 576 10 depends depend VBZ cord-001397-nrq4ncdf 576 11 upon upon IN cord-001397-nrq4ncdf 576 12 ecological ecological JJ cord-001397-nrq4ncdf 576 13 and and CC cord-001397-nrq4ncdf 576 14 environmental environmental JJ cord-001397-nrq4ncdf 576 15 forces force NNS cord-001397-nrq4ncdf 576 16 , , , cord-001397-nrq4ncdf 576 17 but but CC cord-001397-nrq4ncdf 576 18 these these DT cord-001397-nrq4ncdf 576 19 latter latter JJ cord-001397-nrq4ncdf 576 20 factors factor NNS cord-001397-nrq4ncdf 576 21 are be VBP cord-001397-nrq4ncdf 576 22 wholly wholly RB cord-001397-nrq4ncdf 576 23 beyond beyond IN cord-001397-nrq4ncdf 576 24 the the DT cord-001397-nrq4ncdf 576 25 scope scope NN cord-001397-nrq4ncdf 576 26 of of IN cord-001397-nrq4ncdf 576 27 this this DT cord-001397-nrq4ncdf 576 28 limited limited JJ cord-001397-nrq4ncdf 576 29 review review NN cord-001397-nrq4ncdf 576 30 . . . cord-001397-nrq4ncdf 577 1 Multiple Multiple NNP cord-001397-nrq4ncdf 577 2 RNA RNA NNP cord-001397-nrq4ncdf 577 3 and and CC cord-001397-nrq4ncdf 577 4 DNA dna NN cord-001397-nrq4ncdf 577 5 viruses virus NNS cord-001397-nrq4ncdf 577 6 are be VBP cord-001397-nrq4ncdf 577 7 known know VBN cord-001397-nrq4ncdf 577 8 to to TO cord-001397-nrq4ncdf 577 9 establish establish VB cord-001397-nrq4ncdf 577 10 persistence persistence NN cord-001397-nrq4ncdf 577 11 in in IN cord-001397-nrq4ncdf 577 12 culture culture NN cord-001397-nrq4ncdf 577 13 as as RB cord-001397-nrq4ncdf 577 14 well well RB cord-001397-nrq4ncdf 577 15 as as IN cord-001397-nrq4ncdf 577 16 in in IN cord-001397-nrq4ncdf 577 17 humans human NNS cord-001397-nrq4ncdf 577 18 and and CC cord-001397-nrq4ncdf 577 19 animals animal NNS cord-001397-nrq4ncdf 577 20 . . . cord-001397-nrq4ncdf 578 1 Consideration consideration NN cord-001397-nrq4ncdf 578 2 of of IN cord-001397-nrq4ncdf 578 3 several several JJ cord-001397-nrq4ncdf 578 4 may may MD cord-001397-nrq4ncdf 578 5 provide provide VB cord-001397-nrq4ncdf 578 6 insight insight NN cord-001397-nrq4ncdf 578 7 , , , cord-001397-nrq4ncdf 578 8 if if IN cord-001397-nrq4ncdf 578 9 not not RB cord-001397-nrq4ncdf 578 10 direct direct JJ cord-001397-nrq4ncdf 578 11 parallels parallel NNS cord-001397-nrq4ncdf 578 12 , , , cord-001397-nrq4ncdf 578 13 useful useful JJ cord-001397-nrq4ncdf 578 14 in in IN cord-001397-nrq4ncdf 578 15 the the DT cord-001397-nrq4ncdf 578 16 study study NN cord-001397-nrq4ncdf 578 17 of of IN cord-001397-nrq4ncdf 578 18 biology biology NN cord-001397-nrq4ncdf 578 19 of of IN cord-001397-nrq4ncdf 578 20 persistent persistent JJ cord-001397-nrq4ncdf 578 21 VBFV VBFV NNP cord-001397-nrq4ncdf 578 22 infections infection NNS cord-001397-nrq4ncdf 578 23 . . . cord-001397-nrq4ncdf 579 1 The the DT cord-001397-nrq4ncdf 579 2 Hepacivirus Hepacivirus NNP cord-001397-nrq4ncdf 579 3 genus genus NN cord-001397-nrq4ncdf 579 4 , , , cord-001397-nrq4ncdf 579 5 containing contain VBG cord-001397-nrq4ncdf 579 6 hepatitis hepatitis NN cord-001397-nrq4ncdf 579 7 C C NNP cord-001397-nrq4ncdf 579 8 virus virus NN cord-001397-nrq4ncdf 579 9 ( ( -LRB- cord-001397-nrq4ncdf 579 10 HCV HCV NNP cord-001397-nrq4ncdf 579 11 ) ) -RRB- cord-001397-nrq4ncdf 579 12 species specie NNS cord-001397-nrq4ncdf 579 13 , , , cord-001397-nrq4ncdf 579 14 belongs belong VBZ cord-001397-nrq4ncdf 579 15 to to IN cord-001397-nrq4ncdf 579 16 the the DT cord-001397-nrq4ncdf 579 17 Flaviviridae Flaviviridae NNP cord-001397-nrq4ncdf 579 18 family family NN cord-001397-nrq4ncdf 579 19 , , , cord-001397-nrq4ncdf 579 20 together together RB cord-001397-nrq4ncdf 579 21 with with IN cord-001397-nrq4ncdf 579 22 the the DT cord-001397-nrq4ncdf 579 23 Flavivirus Flavivirus NNP cord-001397-nrq4ncdf 579 24 genus genus NN cord-001397-nrq4ncdf 579 25 under under IN cord-001397-nrq4ncdf 579 26 which which WDT cord-001397-nrq4ncdf 579 27 VBFVs vbfv NNS cord-001397-nrq4ncdf 579 28 are be VBP cord-001397-nrq4ncdf 579 29 classified classify VBN cord-001397-nrq4ncdf 579 30 . . . cord-001397-nrq4ncdf 580 1 Despite despite IN cord-001397-nrq4ncdf 580 2 the the DT cord-001397-nrq4ncdf 580 3 virus virus NN cord-001397-nrq4ncdf 580 4 - - HYPH cord-001397-nrq4ncdf 580 5 specific specific JJ cord-001397-nrq4ncdf 580 6 cytotoxic cytotoxic JJ cord-001397-nrq4ncdf 580 7 T t NN cord-001397-nrq4ncdf 580 8 lymphocytes lymphocyte NNS cord-001397-nrq4ncdf 580 9 and and CC cord-001397-nrq4ncdf 580 10 antibodies antibody NNS cord-001397-nrq4ncdf 580 11 , , , cord-001397-nrq4ncdf 580 12 persistent persistent JJ cord-001397-nrq4ncdf 580 13 HCV HCV NNP cord-001397-nrq4ncdf 580 14 infections infection NNS cord-001397-nrq4ncdf 580 15 , , , cord-001397-nrq4ncdf 580 16 which which WDT cord-001397-nrq4ncdf 580 17 are be VBP cord-001397-nrq4ncdf 580 18 established establish VBN cord-001397-nrq4ncdf 580 19 with with IN cord-001397-nrq4ncdf 580 20 high high JJ cord-001397-nrq4ncdf 580 21 efficiency efficiency NN cord-001397-nrq4ncdf 580 22 , , , cord-001397-nrq4ncdf 580 23 are be VBP cord-001397-nrq4ncdf 580 24 known know VBN cord-001397-nrq4ncdf 580 25 to to TO cord-001397-nrq4ncdf 580 26 occur occur VB cord-001397-nrq4ncdf 580 27 in in IN cord-001397-nrq4ncdf 580 28 humans human NNS cord-001397-nrq4ncdf 580 29 and and CC cord-001397-nrq4ncdf 580 30 animals animal NNS cord-001397-nrq4ncdf 580 31 , , , cord-001397-nrq4ncdf 580 32 such such JJ cord-001397-nrq4ncdf 580 33 as as IN cord-001397-nrq4ncdf 580 34 chimpanzees chimpanzee NNS cord-001397-nrq4ncdf 580 35 ( ( -LRB- cord-001397-nrq4ncdf 581 1 Main Main NNP cord-001397-nrq4ncdf 581 2 et et FW cord-001397-nrq4ncdf 581 3 al al NNP cord-001397-nrq4ncdf 581 4 . . NNP cord-001397-nrq4ncdf 581 5 , , , cord-001397-nrq4ncdf 581 6 1979 1979 CD cord-001397-nrq4ncdf 582 1 ; ; : cord-001397-nrq4ncdf 582 2 Caini Caini NNP cord-001397-nrq4ncdf 582 3 et et NNP cord-001397-nrq4ncdf 582 4 al al NNP cord-001397-nrq4ncdf 582 5 . . . cord-001397-nrq4ncdf 583 1 , , , cord-001397-nrq4ncdf 583 2 2012 2012 CD cord-001397-nrq4ncdf 583 3 ; ; : cord-001397-nrq4ncdf 583 4 McNally McNally NNP cord-001397-nrq4ncdf 583 5 et et NNP cord-001397-nrq4ncdf 583 6 al al NNP cord-001397-nrq4ncdf 583 7 . . NNP cord-001397-nrq4ncdf 583 8 , , , cord-001397-nrq4ncdf 583 9 2012 2012 CD cord-001397-nrq4ncdf 583 10 ) ) -RRB- cord-001397-nrq4ncdf 583 11 . . . cord-001397-nrq4ncdf 584 1 HCV HCV NNP cord-001397-nrq4ncdf 584 2 persistence persistence NN cord-001397-nrq4ncdf 584 3 is be VBZ cord-001397-nrq4ncdf 584 4 associated associate VBN cord-001397-nrq4ncdf 584 5 with with IN cord-001397-nrq4ncdf 584 6 various various JJ cord-001397-nrq4ncdf 584 7 strategies strategy NNS cord-001397-nrq4ncdf 584 8 , , , cord-001397-nrq4ncdf 584 9 such such JJ cord-001397-nrq4ncdf 584 10 as as IN cord-001397-nrq4ncdf 584 11 the the DT cord-001397-nrq4ncdf 584 12 high high JJ cord-001397-nrq4ncdf 584 13 genetic genetic JJ cord-001397-nrq4ncdf 584 14 variability variability NN cord-001397-nrq4ncdf 584 15 that that WDT cord-001397-nrq4ncdf 584 16 facilitates facilitate VBZ cord-001397-nrq4ncdf 584 17 passive passive JJ cord-001397-nrq4ncdf 584 18 immune immune JJ cord-001397-nrq4ncdf 584 19 evasion evasion NN cord-001397-nrq4ncdf 584 20 . . . cord-001397-nrq4ncdf 585 1 In in IN cord-001397-nrq4ncdf 585 2 vivo vivo NN cord-001397-nrq4ncdf 585 3 , , , cord-001397-nrq4ncdf 585 4 HCV HCV NNP cord-001397-nrq4ncdf 585 5 fails fail VBZ cord-001397-nrq4ncdf 585 6 to to TO cord-001397-nrq4ncdf 585 7 activate activate VB cord-001397-nrq4ncdf 585 8 CD4 CD4 NNP cord-001397-nrq4ncdf 585 9 + + CC cord-001397-nrq4ncdf 585 10 T t NN cord-001397-nrq4ncdf 585 11 cells cell NNS cord-001397-nrq4ncdf 585 12 , , , cord-001397-nrq4ncdf 585 13 leading lead VBG cord-001397-nrq4ncdf 585 14 to to IN cord-001397-nrq4ncdf 585 15 exhaustion exhaustion NN cord-001397-nrq4ncdf 585 16 of of IN cord-001397-nrq4ncdf 585 17 CD8 CD8 NNP cord-001397-nrq4ncdf 585 18 + + CC cord-001397-nrq4ncdf 585 19 T T NNP cord-001397-nrq4ncdf 585 20 cells cell NNS cord-001397-nrq4ncdf 585 21 . . . cord-001397-nrq4ncdf 586 1 At at IN cord-001397-nrq4ncdf 586 2 cellular cellular JJ cord-001397-nrq4ncdf 586 3 level level NN cord-001397-nrq4ncdf 586 4 , , , cord-001397-nrq4ncdf 586 5 HCV HCV NNP cord-001397-nrq4ncdf 586 6 can can MD cord-001397-nrq4ncdf 586 7 block block VB cord-001397-nrq4ncdf 586 8 interferon interferon NN cord-001397-nrq4ncdf 586 9 induction induction NN cord-001397-nrq4ncdf 586 10 by by IN cord-001397-nrq4ncdf 586 11 blocking block VBG cord-001397-nrq4ncdf 586 12 RIG rig NN cord-001397-nrq4ncdf 586 13 - - : cord-001397-nrq4ncdf 586 14 I i NN cord-001397-nrq4ncdf 586 15 and and CC cord-001397-nrq4ncdf 586 16 mitochondrial mitochondrial JJ cord-001397-nrq4ncdf 586 17 antiviral antiviral JJ cord-001397-nrq4ncdf 586 18 signaling signaling NN cord-001397-nrq4ncdf 586 19 ( ( -LRB- cord-001397-nrq4ncdf 586 20 MAVS MAVS NNP cord-001397-nrq4ncdf 586 21 ) ) -RRB- cord-001397-nrq4ncdf 586 22 using use VBG cord-001397-nrq4ncdf 586 23 its -PRON- PRP$ cord-001397-nrq4ncdf 586 24 NS3-NS4A NS3-NS4A NNP cord-001397-nrq4ncdf 586 25 protease protease NN cord-001397-nrq4ncdf 586 26 , , , cord-001397-nrq4ncdf 586 27 which which WDT cord-001397-nrq4ncdf 586 28 cleaves cleave VBZ cord-001397-nrq4ncdf 586 29 the the DT cord-001397-nrq4ncdf 586 30 IFN IFN NNP cord-001397-nrq4ncdf 586 31 promoter promoter NN cord-001397-nrq4ncdf 586 32 - - HYPH cord-001397-nrq4ncdf 586 33 stimulator stimulator NN cord-001397-nrq4ncdf 586 34 1 1 CD cord-001397-nrq4ncdf 586 35 ( ( -LRB- cord-001397-nrq4ncdf 586 36 Gould Gould NNP cord-001397-nrq4ncdf 586 37 , , , cord-001397-nrq4ncdf 586 38 2001 2001 CD cord-001397-nrq4ncdf 586 39 ; ; : cord-001397-nrq4ncdf 586 40 Muñoz Muñoz NNP cord-001397-nrq4ncdf 586 41 - - HYPH cord-001397-nrq4ncdf 586 42 Jord Jord NNP cord-001397-nrq4ncdf 586 43 an an NNP cord-001397-nrq4ncdf 586 44 et et FW cord-001397-nrq4ncdf 586 45 al al NNP cord-001397-nrq4ncdf 586 46 . . NNP cord-001397-nrq4ncdf 586 47 , , , cord-001397-nrq4ncdf 586 48 2005 2005 CD cord-001397-nrq4ncdf 586 49 ; ; : cord-001397-nrq4ncdf 587 1 Baril Baril NNP cord-001397-nrq4ncdf 587 2 et et NNP cord-001397-nrq4ncdf 587 3 al al NNP cord-001397-nrq4ncdf 587 4 . . . cord-001397-nrq4ncdf 588 1 , , , cord-001397-nrq4ncdf 588 2 2009 2009 CD cord-001397-nrq4ncdf 588 3 ; ; : cord-001397-nrq4ncdf 588 4 Hudopisk Hudopisk NNP cord-001397-nrq4ncdf 588 5 et et NNP cord-001397-nrq4ncdf 588 6 al al NNP cord-001397-nrq4ncdf 588 7 . . NNP cord-001397-nrq4ncdf 588 8 , , , cord-001397-nrq4ncdf 588 9 2013 2013 CD cord-001397-nrq4ncdf 588 10 ; ; : cord-001397-nrq4ncdf 589 1 Perera Perera NNP cord-001397-nrq4ncdf 589 2 - - HYPH cord-001397-nrq4ncdf 589 3 Lecoin Lecoin NNP cord-001397-nrq4ncdf 589 4 et et FW cord-001397-nrq4ncdf 589 5 al al NNP cord-001397-nrq4ncdf 589 6 . . NNP cord-001397-nrq4ncdf 589 7 , , , cord-001397-nrq4ncdf 589 8 2013 2013 CD cord-001397-nrq4ncdf 589 9 ) ) -RRB- cord-001397-nrq4ncdf 589 10 . . . cord-001397-nrq4ncdf 590 1 Hantavirus hantavirus NN cord-001397-nrq4ncdf 590 2 infections infection NNS cord-001397-nrq4ncdf 590 3 are be VBP cord-001397-nrq4ncdf 590 4 another another DT cord-001397-nrq4ncdf 590 5 interesting interesting JJ cord-001397-nrq4ncdf 590 6 example example NN cord-001397-nrq4ncdf 590 7 of of IN cord-001397-nrq4ncdf 590 8 viral viral JJ cord-001397-nrq4ncdf 590 9 persistence persistence NN cord-001397-nrq4ncdf 590 10 . . . cord-001397-nrq4ncdf 591 1 Hantaviruses Hantaviruses NNP cord-001397-nrq4ncdf 591 2 are be VBP cord-001397-nrq4ncdf 591 3 segmented segmented JJ cord-001397-nrq4ncdf 591 4 , , , cord-001397-nrq4ncdf 591 5 RNA RNA NNP cord-001397-nrq4ncdf 591 6 viruses virus NNS cord-001397-nrq4ncdf 591 7 that that WDT cord-001397-nrq4ncdf 591 8 cause cause VBP cord-001397-nrq4ncdf 591 9 lifelong lifelong JJ cord-001397-nrq4ncdf 591 10 infections infection NNS cord-001397-nrq4ncdf 591 11 in in IN cord-001397-nrq4ncdf 591 12 their -PRON- PRP$ cord-001397-nrq4ncdf 591 13 reservoir reservoir NN cord-001397-nrq4ncdf 591 14 rodent rodent NN cord-001397-nrq4ncdf 591 15 hosts host NNS cord-001397-nrq4ncdf 591 16 , , , cord-001397-nrq4ncdf 591 17 despite despite IN cord-001397-nrq4ncdf 591 18 high high JJ cord-001397-nrq4ncdf 591 19 levels level NNS cord-001397-nrq4ncdf 591 20 of of IN cord-001397-nrq4ncdf 591 21 neutralizing neutralize VBG cord-001397-nrq4ncdf 591 22 antibodies antibody NNS cord-001397-nrq4ncdf 591 23 ( ( -LRB- cord-001397-nrq4ncdf 591 24 Botten Botten NNP cord-001397-nrq4ncdf 591 25 et et NNP cord-001397-nrq4ncdf 591 26 al al NNP cord-001397-nrq4ncdf 591 27 . . NNP cord-001397-nrq4ncdf 591 28 , , , cord-001397-nrq4ncdf 591 29 2000 2000 CD cord-001397-nrq4ncdf 591 30 ; ; : cord-001397-nrq4ncdf 591 31 Meyer Meyer NNP cord-001397-nrq4ncdf 591 32 & & CC cord-001397-nrq4ncdf 591 33 Schmaljohn Schmaljohn NNP cord-001397-nrq4ncdf 591 34 , , , cord-001397-nrq4ncdf 591 35 2000 2000 CD cord-001397-nrq4ncdf 591 36 ; ; : cord-001397-nrq4ncdf 591 37 Easterbrook Easterbrook NNP cord-001397-nrq4ncdf 591 38 & & CC cord-001397-nrq4ncdf 591 39 Klein Klein NNP cord-001397-nrq4ncdf 591 40 , , , cord-001397-nrq4ncdf 591 41 2008 2008 CD cord-001397-nrq4ncdf 591 42 ) ) -RRB- cord-001397-nrq4ncdf 591 43 . . . cord-001397-nrq4ncdf 592 1 Pathogen pathogen NN cord-001397-nrq4ncdf 592 2 recognition recognition NN cord-001397-nrq4ncdf 592 3 receptors receptor NNS cord-001397-nrq4ncdf 592 4 , , , cord-001397-nrq4ncdf 592 5 such such JJ cord-001397-nrq4ncdf 592 6 as as IN cord-001397-nrq4ncdf 592 7 RIG rig NN cord-001397-nrq4ncdf 592 8 - - : cord-001397-nrq4ncdf 592 9 I I NNP cord-001397-nrq4ncdf 592 10 and and CC cord-001397-nrq4ncdf 592 11 TLR7 TLR7 NNP cord-001397-nrq4ncdf 592 12 , , , cord-001397-nrq4ncdf 592 13 are be VBP cord-001397-nrq4ncdf 592 14 not not RB cord-001397-nrq4ncdf 592 15 elevated elevate VBN cord-001397-nrq4ncdf 592 16 in in IN cord-001397-nrq4ncdf 592 17 the the DT cord-001397-nrq4ncdf 592 18 lungs lung NNS cord-001397-nrq4ncdf 592 19 of of IN cord-001397-nrq4ncdf 592 20 infected infected JJ cord-001397-nrq4ncdf 592 21 rats rat NNS cord-001397-nrq4ncdf 592 22 , , , cord-001397-nrq4ncdf 592 23 suggesting suggest VBG cord-001397-nrq4ncdf 592 24 that that IN cord-001397-nrq4ncdf 592 25 evasion evasion NN cord-001397-nrq4ncdf 592 26 of of IN cord-001397-nrq4ncdf 592 27 viral viral JJ cord-001397-nrq4ncdf 592 28 recognition recognition NN cord-001397-nrq4ncdf 592 29 may may MD cord-001397-nrq4ncdf 592 30 contribute contribute VB cord-001397-nrq4ncdf 592 31 toward toward IN cord-001397-nrq4ncdf 592 32 the the DT cord-001397-nrq4ncdf 592 33 establishment establishment NN cord-001397-nrq4ncdf 592 34 of of IN cord-001397-nrq4ncdf 592 35 a a DT cord-001397-nrq4ncdf 592 36 persistent persistent JJ cord-001397-nrq4ncdf 592 37 infection infection NN cord-001397-nrq4ncdf 592 38 . . . cord-001397-nrq4ncdf 593 1 Perhaps perhaps RB cord-001397-nrq4ncdf 593 2 , , , cord-001397-nrq4ncdf 593 3 the the DT cord-001397-nrq4ncdf 593 4 reason reason NN cord-001397-nrq4ncdf 593 5 for for IN cord-001397-nrq4ncdf 593 6 noninduction noninduction NN cord-001397-nrq4ncdf 593 7 of of IN cord-001397-nrq4ncdf 593 8 RIG rig NN cord-001397-nrq4ncdf 593 9 - - : cord-001397-nrq4ncdf 593 10 I -PRON- PRP cord-001397-nrq4ncdf 593 11 is be VBZ cord-001397-nrq4ncdf 593 12 the the DT cord-001397-nrq4ncdf 593 13 fact fact NN cord-001397-nrq4ncdf 593 14 that that IN cord-001397-nrq4ncdf 593 15 hantaviruses hantaviruse NNS cord-001397-nrq4ncdf 593 16 do do VBP cord-001397-nrq4ncdf 593 17 not not RB cord-001397-nrq4ncdf 593 18 produce produce VB cord-001397-nrq4ncdf 593 19 detectable detectable JJ cord-001397-nrq4ncdf 593 20 amounts amount NNS cord-001397-nrq4ncdf 593 21 of of IN cord-001397-nrq4ncdf 593 22 dsRNA dsrna NN cord-001397-nrq4ncdf 594 1 ( ( -LRB- cord-001397-nrq4ncdf 594 2 Wang Wang NNP cord-001397-nrq4ncdf 594 3 et et NNP cord-001397-nrq4ncdf 594 4 al al NNP cord-001397-nrq4ncdf 594 5 . . NNP cord-001397-nrq4ncdf 594 6 , , , cord-001397-nrq4ncdf 594 7 2011 2011 CD cord-001397-nrq4ncdf 594 8 ) ) -RRB- cord-001397-nrq4ncdf 594 9 . . . cord-001397-nrq4ncdf 595 1 IFNs ifn NNS cord-001397-nrq4ncdf 595 2 , , , cord-001397-nrq4ncdf 595 3 such such JJ cord-001397-nrq4ncdf 595 4 as as IN cord-001397-nrq4ncdf 595 5 IFN IFN NNP cord-001397-nrq4ncdf 595 6 - - HYPH cord-001397-nrq4ncdf 595 7 b b NNP cord-001397-nrq4ncdf 595 8 , , , cord-001397-nrq4ncdf 595 9 IFN IFN NNP cord-001397-nrq4ncdf 595 10 - - HYPH cord-001397-nrq4ncdf 595 11 k k NNP cord-001397-nrq4ncdf 595 12 , , , cord-001397-nrq4ncdf 595 13 MxA mxa NN cord-001397-nrq4ncdf 595 14 , , , cord-001397-nrq4ncdf 595 15 and and CC cord-001397-nrq4ncdf 595 16 pro pro JJ cord-001397-nrq4ncdf 595 17 - - JJ cord-001397-nrq4ncdf 595 18 inflammatory inflammatory JJ cord-001397-nrq4ncdf 595 19 chemokines chemokine NNS cord-001397-nrq4ncdf 595 20 , , , cord-001397-nrq4ncdf 595 21 cytokines cytokine NNS cord-001397-nrq4ncdf 595 22 , , , cord-001397-nrq4ncdf 595 23 and and CC cord-001397-nrq4ncdf 595 24 transcription transcription NN cord-001397-nrq4ncdf 595 25 factor factor NN cord-001397-nrq4ncdf 595 26 genes gene NNS cord-001397-nrq4ncdf 595 27 are be VBP cord-001397-nrq4ncdf 595 28 elevated elevate VBN cord-001397-nrq4ncdf 595 29 midway midway NN cord-001397-nrq4ncdf 595 30 in in IN cord-001397-nrq4ncdf 595 31 the the DT cord-001397-nrq4ncdf 595 32 infection infection NN cord-001397-nrq4ncdf 595 33 followed follow VBN cord-001397-nrq4ncdf 595 34 by by IN cord-001397-nrq4ncdf 595 35 a a DT cord-001397-nrq4ncdf 595 36 down down JJ cord-001397-nrq4ncdf 595 37 - - HYPH cord-001397-nrq4ncdf 595 38 regulation regulation NN cord-001397-nrq4ncdf 595 39 that that WDT cord-001397-nrq4ncdf 595 40 favors favor VBZ cord-001397-nrq4ncdf 595 41 the the DT cord-001397-nrq4ncdf 595 42 expression expression NN cord-001397-nrq4ncdf 595 43 of of IN cord-001397-nrq4ncdf 595 44 TGF TGF NNP cord-001397-nrq4ncdf 595 45 - - HYPH cord-001397-nrq4ncdf 595 46 b b NNP cord-001397-nrq4ncdf 595 47 ( ( -LRB- cord-001397-nrq4ncdf 595 48 Schountz Schountz NNP cord-001397-nrq4ncdf 595 49 et et NNP cord-001397-nrq4ncdf 595 50 al al NNP cord-001397-nrq4ncdf 595 51 . . NNP cord-001397-nrq4ncdf 595 52 , , , cord-001397-nrq4ncdf 595 53 2012 2012 CD cord-001397-nrq4ncdf 595 54 ) ) -RRB- cord-001397-nrq4ncdf 595 55 . . . cord-001397-nrq4ncdf 596 1 A a DT cord-001397-nrq4ncdf 596 2 continued continued JJ cord-001397-nrq4ncdf 596 3 up up NN cord-001397-nrq4ncdf 596 4 - - HYPH cord-001397-nrq4ncdf 596 5 regulation regulation NN cord-001397-nrq4ncdf 596 6 of of IN cord-001397-nrq4ncdf 596 7 the the DT cord-001397-nrq4ncdf 596 8 cytokines cytokine NNS cord-001397-nrq4ncdf 596 9 could could MD cord-001397-nrq4ncdf 596 10 be be VB cord-001397-nrq4ncdf 596 11 detrimental detrimental JJ cord-001397-nrq4ncdf 596 12 to to IN cord-001397-nrq4ncdf 596 13 the the DT cord-001397-nrq4ncdf 596 14 cell cell NN cord-001397-nrq4ncdf 596 15 , , , cord-001397-nrq4ncdf 596 16 and and CC cord-001397-nrq4ncdf 596 17 the the DT cord-001397-nrq4ncdf 596 18 virus virus NN cord-001397-nrq4ncdf 596 19 would would MD cord-001397-nrq4ncdf 596 20 fail fail VB cord-001397-nrq4ncdf 596 21 to to TO cord-001397-nrq4ncdf 596 22 persist persist VB cord-001397-nrq4ncdf 596 23 . . . cord-001397-nrq4ncdf 597 1 Results result NNS cord-001397-nrq4ncdf 597 2 of of IN cord-001397-nrq4ncdf 597 3 a a DT cord-001397-nrq4ncdf 597 4 recently recently RB cord-001397-nrq4ncdf 597 5 established establish VBN cord-001397-nrq4ncdf 597 6 animal animal NN cord-001397-nrq4ncdf 597 7 model model NN cord-001397-nrq4ncdf 597 8 also also RB cord-001397-nrq4ncdf 597 9 show show VBP cord-001397-nrq4ncdf 597 10 that that IN cord-001397-nrq4ncdf 597 11 host host NN cord-001397-nrq4ncdf 597 12 - - HYPH cord-001397-nrq4ncdf 597 13 adapted adapt VBN cord-001397-nrq4ncdf 597 14 SNV SNV NNP cord-001397-nrq4ncdf 597 15 achieves achieve VBZ cord-001397-nrq4ncdf 597 16 prolonged prolong VBN cord-001397-nrq4ncdf 597 17 and and CC cord-001397-nrq4ncdf 597 18 disseminated disseminate VBN cord-001397-nrq4ncdf 597 19 infection infection NN cord-001397-nrq4ncdf 597 20 , , , cord-001397-nrq4ncdf 597 21 with with IN cord-001397-nrq4ncdf 597 22 no no DT cord-001397-nrq4ncdf 597 23 disease disease NN cord-001397-nrq4ncdf 597 24 in in IN cord-001397-nrq4ncdf 597 25 hamsters hamster NNS cord-001397-nrq4ncdf 597 26 ( ( -LRB- cord-001397-nrq4ncdf 597 27 Safronetz Safronetz NNP cord-001397-nrq4ncdf 597 28 et et NNP cord-001397-nrq4ncdf 597 29 al al NNP cord-001397-nrq4ncdf 597 30 . . NNP cord-001397-nrq4ncdf 597 31 , , , cord-001397-nrq4ncdf 597 32 2013 2013 CD cord-001397-nrq4ncdf 597 33 ) ) -RRB- cord-001397-nrq4ncdf 597 34 . . . cord-001397-nrq4ncdf 598 1 Therefore therefore RB cord-001397-nrq4ncdf 598 2 , , , cord-001397-nrq4ncdf 598 3 hantaviruses hantaviruse NNS cord-001397-nrq4ncdf 598 4 may may MD cord-001397-nrq4ncdf 598 5 have have VB cord-001397-nrq4ncdf 598 6 evolved evolve VBN cord-001397-nrq4ncdf 598 7 mechanisms mechanism NNS cord-001397-nrq4ncdf 598 8 of of IN cord-001397-nrq4ncdf 598 9 manipulating manipulate VBG cord-001397-nrq4ncdf 598 10 target target NN cord-001397-nrq4ncdf 598 11 genes gene NNS cord-001397-nrq4ncdf 598 12 , , , cord-001397-nrq4ncdf 598 13 which which WDT cord-001397-nrq4ncdf 598 14 establishes establish VBZ cord-001397-nrq4ncdf 598 15 persistence persistence NN cord-001397-nrq4ncdf 598 16 when when WRB cord-001397-nrq4ncdf 598 17 induced induce VBN cord-001397-nrq4ncdf 598 18 . . . cord-001397-nrq4ncdf 599 1 One one CD cord-001397-nrq4ncdf 599 2 of of IN cord-001397-nrq4ncdf 599 3 the the DT cord-001397-nrq4ncdf 599 4 best well RBS cord-001397-nrq4ncdf 599 5 - - HYPH cord-001397-nrq4ncdf 599 6 studied study VBN cord-001397-nrq4ncdf 599 7 models model NNS cord-001397-nrq4ncdf 599 8 of of IN cord-001397-nrq4ncdf 599 9 persistent persistent JJ cord-001397-nrq4ncdf 599 10 RNA RNA NNP cord-001397-nrq4ncdf 599 11 virus virus NN cord-001397-nrq4ncdf 599 12 infection infection NN cord-001397-nrq4ncdf 599 13 is be VBZ cord-001397-nrq4ncdf 599 14 the the DT cord-001397-nrq4ncdf 599 15 rodent rodent NN cord-001397-nrq4ncdf 599 16 - - HYPH cord-001397-nrq4ncdf 599 17 borne bear VBN cord-001397-nrq4ncdf 599 18 arenavirus arenavirus NN cord-001397-nrq4ncdf 599 19 , , , cord-001397-nrq4ncdf 599 20 lymphocytic lymphocytic JJ cord-001397-nrq4ncdf 599 21 choriomeningitis choriomeningitis NNP cord-001397-nrq4ncdf 599 22 virus virus NN cord-001397-nrq4ncdf 599 23 ( ( -LRB- cord-001397-nrq4ncdf 599 24 LCMV LCMV NNP cord-001397-nrq4ncdf 599 25 ) ) -RRB- cord-001397-nrq4ncdf 599 26 . . . cord-001397-nrq4ncdf 600 1 In in IN cord-001397-nrq4ncdf 600 2 LCMV LCMV NNP cord-001397-nrq4ncdf 600 3 clone clone NN cord-001397-nrq4ncdf 600 4 13 13 CD cord-001397-nrq4ncdf 600 5 ( ( -LRB- cord-001397-nrq4ncdf 600 6 Cl13 Cl13 NNP cord-001397-nrq4ncdf 600 7 ) ) -RRB- cord-001397-nrq4ncdf 600 8 , , , cord-001397-nrq4ncdf 600 9 a a DT cord-001397-nrq4ncdf 600 10 glutamine glutamine NN cord-001397-nrq4ncdf 600 11 at at IN cord-001397-nrq4ncdf 600 12 position position NN cord-001397-nrq4ncdf 600 13 1079 1079 CD cord-001397-nrq4ncdf 600 14 in in IN cord-001397-nrq4ncdf 600 15 the the DT cord-001397-nrq4ncdf 600 16 glycoprotein glycoprotein NN cord-001397-nrq4ncdf 600 17 ( ( -LRB- cord-001397-nrq4ncdf 600 18 lysine lysine NN cord-001397-nrq4ncdf 600 19 in in IN cord-001397-nrq4ncdf 600 20 the the DT cord-001397-nrq4ncdf 600 21 ARM arm NN cord-001397-nrq4ncdf 600 22 53b 53b CD cord-001397-nrq4ncdf 600 23 strain strain NN cord-001397-nrq4ncdf 600 24 of of IN cord-001397-nrq4ncdf 600 25 LCMV LCMV NNP cord-001397-nrq4ncdf 600 26 ) ) -RRB- cord-001397-nrq4ncdf 600 27 is be VBZ cord-001397-nrq4ncdf 600 28 important important JJ cord-001397-nrq4ncdf 600 29 for for IN cord-001397-nrq4ncdf 600 30 persistence persistence NN cord-001397-nrq4ncdf 600 31 , , , cord-001397-nrq4ncdf 600 32 but but CC cord-001397-nrq4ncdf 600 33 its -PRON- PRP$ cord-001397-nrq4ncdf 600 34 precise precise JJ cord-001397-nrq4ncdf 600 35 function function NN cord-001397-nrq4ncdf 600 36 is be VBZ cord-001397-nrq4ncdf 600 37 unknown unknown JJ cord-001397-nrq4ncdf 600 38 ( ( -LRB- cord-001397-nrq4ncdf 600 39 Salvato Salvato NNP cord-001397-nrq4ncdf 600 40 et et FW cord-001397-nrq4ncdf 600 41 al al NNP cord-001397-nrq4ncdf 600 42 . . NNP cord-001397-nrq4ncdf 600 43 , , , cord-001397-nrq4ncdf 600 44 1991 1991 CD cord-001397-nrq4ncdf 600 45 ; ; : cord-001397-nrq4ncdf 600 46 Moskophidis Moskophidis NNP cord-001397-nrq4ncdf 600 47 et et NNP cord-001397-nrq4ncdf 600 48 al al NNP cord-001397-nrq4ncdf 601 1 . . NNP cord-001397-nrq4ncdf 601 2 , , , cord-001397-nrq4ncdf 601 3 1995 1995 CD cord-001397-nrq4ncdf 601 4 ) ) -RRB- cord-001397-nrq4ncdf 601 5 . . . cord-001397-nrq4ncdf 602 1 The the DT cord-001397-nrq4ncdf 602 2 mechanisms mechanism NNS cord-001397-nrq4ncdf 602 3 of of IN cord-001397-nrq4ncdf 602 4 LCMV LCMV NNP cord-001397-nrq4ncdf 602 5 persistence persistence NN cord-001397-nrq4ncdf 602 6 are be VBP cord-001397-nrq4ncdf 602 7 linked link VBN cord-001397-nrq4ncdf 602 8 to to IN cord-001397-nrq4ncdf 602 9 the the DT cord-001397-nrq4ncdf 602 10 down down JJ cord-001397-nrq4ncdf 602 11 - - HYPH cord-001397-nrq4ncdf 602 12 regulation regulation NN cord-001397-nrq4ncdf 602 13 of of IN cord-001397-nrq4ncdf 602 14 MHC MHC NNP cord-001397-nrq4ncdf 602 15 and and CC cord-001397-nrq4ncdf 602 16 costimulatory costimulatory NNP cord-001397-nrq4ncdf 602 17 molecules molecule NNS cord-001397-nrq4ncdf 602 18 , , , cord-001397-nrq4ncdf 602 19 inflammatory inflammatory JJ cord-001397-nrq4ncdf 602 20 cytokines cytokine NNS cord-001397-nrq4ncdf 602 21 , , , cord-001397-nrq4ncdf 602 22 as as RB cord-001397-nrq4ncdf 602 23 well well RB cord-001397-nrq4ncdf 602 24 as as IN cord-001397-nrq4ncdf 602 25 virus virus NN cord-001397-nrq4ncdf 602 26 - - HYPH cord-001397-nrq4ncdf 602 27 induced induce VBN cord-001397-nrq4ncdf 602 28 production production NN cord-001397-nrq4ncdf 602 29 of of IN cord-001397-nrq4ncdf 602 30 immunosuppressive immunosuppressive JJ cord-001397-nrq4ncdf 602 31 cytokines cytokine NNS cord-001397-nrq4ncdf 602 32 ( ( -LRB- cord-001397-nrq4ncdf 602 33 Ng Ng NNP cord-001397-nrq4ncdf 602 34 et et FW cord-001397-nrq4ncdf 602 35 al al NNP cord-001397-nrq4ncdf 602 36 . . NNP cord-001397-nrq4ncdf 602 37 , , , cord-001397-nrq4ncdf 602 38 2011 2011 CD cord-001397-nrq4ncdf 602 39 ) ) -RRB- cord-001397-nrq4ncdf 602 40 . . . cord-001397-nrq4ncdf 603 1 The the DT cord-001397-nrq4ncdf 603 2 inability inability NN cord-001397-nrq4ncdf 603 3 of of IN cord-001397-nrq4ncdf 603 4 CD134-deficient CD134-deficient NNP cord-001397-nrq4ncdf 603 5 mice mouse NNS cord-001397-nrq4ncdf 603 6 to to TO cord-001397-nrq4ncdf 603 7 control control VB cord-001397-nrq4ncdf 603 8 LCMV LCMV NNP cord-001397-nrq4ncdf 603 9 infection infection NN cord-001397-nrq4ncdf 603 10 over over IN cord-001397-nrq4ncdf 603 11 time time NN cord-001397-nrq4ncdf 603 12 was be VBD cord-001397-nrq4ncdf 603 13 reported report VBN cord-001397-nrq4ncdf 603 14 to to TO cord-001397-nrq4ncdf 603 15 be be VB cord-001397-nrq4ncdf 603 16 a a DT cord-001397-nrq4ncdf 603 17 result result NN cord-001397-nrq4ncdf 603 18 of of IN cord-001397-nrq4ncdf 603 19 CD4 CD4 NNP cord-001397-nrq4ncdf 603 20 and and CC cord-001397-nrq4ncdf 603 21 CD8 CD8 NNP cord-001397-nrq4ncdf 603 22 responses response NNS cord-001397-nrq4ncdf 603 23 ( ( -LRB- cord-001397-nrq4ncdf 603 24 Boettler Boettler NNP cord-001397-nrq4ncdf 603 25 et et NNP cord-001397-nrq4ncdf 603 26 al al NNP cord-001397-nrq4ncdf 603 27 . . NNP cord-001397-nrq4ncdf 603 28 , , , cord-001397-nrq4ncdf 603 29 2012 2012 CD cord-001397-nrq4ncdf 603 30 ) ) -RRB- cord-001397-nrq4ncdf 603 31 . . . cord-001397-nrq4ncdf 604 1 In in IN cord-001397-nrq4ncdf 604 2 addition addition NN cord-001397-nrq4ncdf 604 3 , , , cord-001397-nrq4ncdf 604 4 OX40 OX40 NNP cord-001397-nrq4ncdf 604 5 also also RB cord-001397-nrq4ncdf 604 6 has have VBZ cord-001397-nrq4ncdf 604 7 a a DT cord-001397-nrq4ncdf 604 8 role role NN cord-001397-nrq4ncdf 604 9 in in IN cord-001397-nrq4ncdf 604 10 the the DT cord-001397-nrq4ncdf 604 11 establishment establishment NN cord-001397-nrq4ncdf 604 12 of of IN cord-001397-nrq4ncdf 604 13 persistent persistent JJ cord-001397-nrq4ncdf 604 14 LMCV LMCV NNP cord-001397-nrq4ncdf 604 15 infection infection NN cord-001397-nrq4ncdf 604 16 ( ( -LRB- cord-001397-nrq4ncdf 604 17 Boettler Boettler NNP cord-001397-nrq4ncdf 604 18 et et NNP cord-001397-nrq4ncdf 604 19 al al NNP cord-001397-nrq4ncdf 604 20 . . NNP cord-001397-nrq4ncdf 604 21 , , , cord-001397-nrq4ncdf 604 22 2012 2012 CD cord-001397-nrq4ncdf 604 23 ) ) -RRB- cord-001397-nrq4ncdf 604 24 . . . cord-001397-nrq4ncdf 605 1 A a DT cord-001397-nrq4ncdf 605 2 recent recent JJ cord-001397-nrq4ncdf 605 3 report report NN cord-001397-nrq4ncdf 605 4 showed show VBD cord-001397-nrq4ncdf 605 5 that that IN cord-001397-nrq4ncdf 605 6 IFN IFN NNP cord-001397-nrq4ncdf 605 7 blockade blockade NN cord-001397-nrq4ncdf 605 8 of of IN cord-001397-nrq4ncdf 605 9 type type NN cord-001397-nrq4ncdf 605 10 I -PRON- PRP cord-001397-nrq4ncdf 605 11 IFN IFN NNP cord-001397-nrq4ncdf 605 12 signaling signal VBG cord-001397-nrq4ncdf 605 13 results result NNS cord-001397-nrq4ncdf 605 14 in in IN cord-001397-nrq4ncdf 605 15 a a DT cord-001397-nrq4ncdf 605 16 CD4 CD4 NNP cord-001397-nrq4ncdf 605 17 T T NNP cord-001397-nrq4ncdf 605 18 cell cell NN cord-001397-nrq4ncdf 605 19 - - HYPH cord-001397-nrq4ncdf 605 20 dependent dependent JJ cord-001397-nrq4ncdf 605 21 clearance clearance NN cord-001397-nrq4ncdf 605 22 of of IN cord-001397-nrq4ncdf 605 23 LCMV LCMV NNP cord-001397-nrq4ncdf 605 24 Cl13 Cl13 NNP cord-001397-nrq4ncdf 606 1 ( ( -LRB- cord-001397-nrq4ncdf 606 2 Teijaro Teijaro NNP cord-001397-nrq4ncdf 606 3 et et FW cord-001397-nrq4ncdf 606 4 al al NNP cord-001397-nrq4ncdf 606 5 . . NNP cord-001397-nrq4ncdf 606 6 , , , cord-001397-nrq4ncdf 606 7 2013 2013 CD cord-001397-nrq4ncdf 606 8 ) ) -RRB- cord-001397-nrq4ncdf 606 9 . . . cord-001397-nrq4ncdf 607 1 This this DT cord-001397-nrq4ncdf 607 2 is be VBZ cord-001397-nrq4ncdf 607 3 an an DT cord-001397-nrq4ncdf 607 4 interesting interesting JJ cord-001397-nrq4ncdf 607 5 observation observation NN cord-001397-nrq4ncdf 607 6 considering consider VBG cord-001397-nrq4ncdf 607 7 that that IN cord-001397-nrq4ncdf 607 8 IFN IFN NNP cord-001397-nrq4ncdf 607 9 induction induction NN cord-001397-nrq4ncdf 607 10 is be VBZ cord-001397-nrq4ncdf 607 11 part part NN cord-001397-nrq4ncdf 607 12 of of IN cord-001397-nrq4ncdf 607 13 the the DT cord-001397-nrq4ncdf 607 14 antiviral antiviral JJ cord-001397-nrq4ncdf 607 15 response response NN cord-001397-nrq4ncdf 607 16 and and CC cord-001397-nrq4ncdf 607 17 that that IN cord-001397-nrq4ncdf 607 18 its -PRON- PRP$ cord-001397-nrq4ncdf 607 19 induction induction NN cord-001397-nrq4ncdf 607 20 can can MD cord-001397-nrq4ncdf 607 21 lead lead VB cord-001397-nrq4ncdf 607 22 to to IN cord-001397-nrq4ncdf 607 23 apoptosis apoptosis NN cord-001397-nrq4ncdf 607 24 . . . cord-001397-nrq4ncdf 608 1 However however RB cord-001397-nrq4ncdf 608 2 , , , cord-001397-nrq4ncdf 608 3 the the DT cord-001397-nrq4ncdf 608 4 precise precise JJ cord-001397-nrq4ncdf 608 5 mechanism mechanism NN cord-001397-nrq4ncdf 608 6 of of IN cord-001397-nrq4ncdf 608 7 persistence persistence NN cord-001397-nrq4ncdf 608 8 is be VBZ cord-001397-nrq4ncdf 608 9 not not RB cord-001397-nrq4ncdf 608 10 completely completely RB cord-001397-nrq4ncdf 608 11 clear clear JJ cord-001397-nrq4ncdf 608 12 ( ( -LRB- cord-001397-nrq4ncdf 608 13 Easterbrook Easterbrook NNP cord-001397-nrq4ncdf 608 14 & & CC cord-001397-nrq4ncdf 608 15 Klein Klein NNP cord-001397-nrq4ncdf 608 16 , , , cord-001397-nrq4ncdf 608 17 2008 2008 CD cord-001397-nrq4ncdf 608 18 ) ) -RRB- cord-001397-nrq4ncdf 608 19 , , , cord-001397-nrq4ncdf 608 20 but but CC cord-001397-nrq4ncdf 608 21 it -PRON- PRP cord-001397-nrq4ncdf 608 22 also also RB cord-001397-nrq4ncdf 608 23 demonstrates demonstrate VBZ cord-001397-nrq4ncdf 608 24 ' ' `` cord-001397-nrq4ncdf 608 25 clever clever JJ cord-001397-nrq4ncdf 608 26 ' ' `` cord-001397-nrq4ncdf 608 27 viral viral JJ cord-001397-nrq4ncdf 608 28 manipulation manipulation NN cord-001397-nrq4ncdf 608 29 of of IN cord-001397-nrq4ncdf 608 30 the the DT cord-001397-nrq4ncdf 608 31 host host NN cord-001397-nrq4ncdf 608 32 system system NN cord-001397-nrq4ncdf 608 33 to to TO cord-001397-nrq4ncdf 608 34 establish establish VB cord-001397-nrq4ncdf 608 35 persistence persistence NN cord-001397-nrq4ncdf 608 36 . . . cord-001397-nrq4ncdf 609 1 Coxsackievirus Coxsackievirus NNP cord-001397-nrq4ncdf 609 2 infections infection NNS cord-001397-nrq4ncdf 609 3 are be VBP cord-001397-nrq4ncdf 609 4 another another DT cord-001397-nrq4ncdf 609 5 system system NN cord-001397-nrq4ncdf 609 6 from from IN cord-001397-nrq4ncdf 609 7 which which WDT cord-001397-nrq4ncdf 609 8 lessons lesson NNS cord-001397-nrq4ncdf 609 9 might may MD cord-001397-nrq4ncdf 609 10 be be VB cord-001397-nrq4ncdf 609 11 drawn draw VBN cord-001397-nrq4ncdf 609 12 . . . cord-001397-nrq4ncdf 610 1 Coxsackievirus Coxsackievirus NNP cord-001397-nrq4ncdf 610 2 B3 b3 NN cord-001397-nrq4ncdf 610 3 has have VBZ cord-001397-nrq4ncdf 610 4 been be VBN cord-001397-nrq4ncdf 610 5 implicated implicate VBN cord-001397-nrq4ncdf 610 6 toward toward IN cord-001397-nrq4ncdf 610 7 the the DT cord-001397-nrq4ncdf 610 8 development development NN cord-001397-nrq4ncdf 610 9 of of IN cord-001397-nrq4ncdf 610 10 certain certain JJ cord-001397-nrq4ncdf 610 11 chronic chronic JJ cord-001397-nrq4ncdf 610 12 muscle muscle NN cord-001397-nrq4ncdf 610 13 diseases disease NNS cord-001397-nrq4ncdf 610 14 , , , cord-001397-nrq4ncdf 610 15 such such JJ cord-001397-nrq4ncdf 610 16 as as IN cord-001397-nrq4ncdf 610 17 chronic chronic JJ cord-001397-nrq4ncdf 610 18 inflammatory inflammatory JJ cord-001397-nrq4ncdf 610 19 myopathy myopathy NN cord-001397-nrq4ncdf 610 20 ( ( -LRB- cord-001397-nrq4ncdf 611 1 Lodge Lodge NNP cord-001397-nrq4ncdf 611 2 et et NNP cord-001397-nrq4ncdf 611 3 al al NNP cord-001397-nrq4ncdf 611 4 . . NNP cord-001397-nrq4ncdf 611 5 , , , cord-001397-nrq4ncdf 611 6 1987 1987 CD cord-001397-nrq4ncdf 611 7 ; ; : cord-001397-nrq4ncdf 611 8 Tam Tam NNP cord-001397-nrq4ncdf 611 9 & & CC cord-001397-nrq4ncdf 611 10 Messner Messner NNP cord-001397-nrq4ncdf 611 11 , , , cord-001397-nrq4ncdf 611 12 1999 1999 CD cord-001397-nrq4ncdf 611 13 ) ) -RRB- cord-001397-nrq4ncdf 611 14 . . . cord-001397-nrq4ncdf 612 1 Coxsackievirus Coxsackievirus NNP cord-001397-nrq4ncdf 612 2 persistence persistence NN cord-001397-nrq4ncdf 612 3 in in IN cord-001397-nrq4ncdf 612 4 cell cell NN cord-001397-nrq4ncdf 612 5 culture culture NN cord-001397-nrq4ncdf 612 6 can can MD cord-001397-nrq4ncdf 612 7 take take VB cord-001397-nrq4ncdf 612 8 two two CD cord-001397-nrq4ncdf 612 9 forms form NNS cord-001397-nrq4ncdf 612 10 : : : cord-001397-nrq4ncdf 612 11 ( ( -LRB- cord-001397-nrq4ncdf 612 12 1 1 LS cord-001397-nrq4ncdf 612 13 ) ) -RRB- cord-001397-nrq4ncdf 612 14 an an DT cord-001397-nrq4ncdf 612 15 incurable incurable JJ cord-001397-nrq4ncdf 612 16 steady steady JJ cord-001397-nrq4ncdf 612 17 state state NN cord-001397-nrq4ncdf 612 18 characterized characterize VBN cord-001397-nrq4ncdf 612 19 by by IN cord-001397-nrq4ncdf 612 20 nonlytic nonlytic NNP cord-001397-nrq4ncdf 612 21 virus virus NN cord-001397-nrq4ncdf 612 22 infection infection NN cord-001397-nrq4ncdf 612 23 and and CC cord-001397-nrq4ncdf 612 24 ( ( -LRB- cord-001397-nrq4ncdf 612 25 2 2 LS cord-001397-nrq4ncdf 612 26 ) ) -RRB- cord-001397-nrq4ncdf 612 27 an an DT cord-001397-nrq4ncdf 612 28 antiviral antiviral JJ cord-001397-nrq4ncdf 612 29 - - HYPH cord-001397-nrq4ncdf 612 30 curable curable JJ cord-001397-nrq4ncdf 612 31 carrier carrier NN cord-001397-nrq4ncdf 612 32 culture culture NN cord-001397-nrq4ncdf 612 33 system system NN cord-001397-nrq4ncdf 612 34 ( ( -LRB- cord-001397-nrq4ncdf 612 35 Brinton Brinton NNP cord-001397-nrq4ncdf 612 36 , , , cord-001397-nrq4ncdf 612 37 2013 2013 CD cord-001397-nrq4ncdf 612 38 ; ; : cord-001397-nrq4ncdf 613 1 Pierson Pierson NNP cord-001397-nrq4ncdf 613 2 & & CC cord-001397-nrq4ncdf 613 3 Kielian Kielian NNP cord-001397-nrq4ncdf 613 4 , , , cord-001397-nrq4ncdf 613 5 2013 2013 CD cord-001397-nrq4ncdf 613 6 ) ) -RRB- cord-001397-nrq4ncdf 613 7 . . . cord-001397-nrq4ncdf 614 1 While while IN cord-001397-nrq4ncdf 614 2 mechanisms mechanism NNS cord-001397-nrq4ncdf 614 3 of of IN cord-001397-nrq4ncdf 614 4 coxsackievirus coxsackievirus NNP cord-001397-nrq4ncdf 614 5 persistence persistence NN cord-001397-nrq4ncdf 614 6 are be VBP cord-001397-nrq4ncdf 614 7 not not RB cord-001397-nrq4ncdf 614 8 completely completely RB cord-001397-nrq4ncdf 614 9 understood understand VBN cord-001397-nrq4ncdf 614 10 , , , cord-001397-nrq4ncdf 614 11 down down IN cord-001397-nrq4ncdf 614 12 - - HYPH cord-001397-nrq4ncdf 614 13 regulation regulation NN cord-001397-nrq4ncdf 614 14 of of IN cord-001397-nrq4ncdf 614 15 the the DT cord-001397-nrq4ncdf 614 16 coxsackievirus coxsackievirus NNP cord-001397-nrq4ncdf 614 17 receptor receptor NN cord-001397-nrq4ncdf 614 18 ( ( -LRB- cord-001397-nrq4ncdf 614 19 CAR car NN cord-001397-nrq4ncdf 614 20 ) ) -RRB- cord-001397-nrq4ncdf 614 21 has have VBZ cord-001397-nrq4ncdf 614 22 been be VBN cord-001397-nrq4ncdf 614 23 suggested suggest VBN cord-001397-nrq4ncdf 614 24 to to TO cord-001397-nrq4ncdf 614 25 play play VB cord-001397-nrq4ncdf 614 26 a a DT cord-001397-nrq4ncdf 614 27 role role NN cord-001397-nrq4ncdf 614 28 in in IN cord-001397-nrq4ncdf 614 29 viral viral JJ cord-001397-nrq4ncdf 614 30 persistence persistence NN cord-001397-nrq4ncdf 614 31 ( ( -LRB- cord-001397-nrq4ncdf 614 32 Varatharaj Varatharaj NNP cord-001397-nrq4ncdf 614 33 , , , cord-001397-nrq4ncdf 614 34 2010 2010 CD cord-001397-nrq4ncdf 614 35 ) ) -RRB- cord-001397-nrq4ncdf 614 36 . . . cord-001397-nrq4ncdf 615 1 Down down IN cord-001397-nrq4ncdf 615 2 - - HYPH cord-001397-nrq4ncdf 615 3 regulation regulation NN cord-001397-nrq4ncdf 615 4 of of IN cord-001397-nrq4ncdf 615 5 CAR car NN cord-001397-nrq4ncdf 615 6 in in IN cord-001397-nrq4ncdf 615 7 coxsackievirus coxsackievirus NNP cord-001397-nrq4ncdf 615 8 - - HYPH cord-001397-nrq4ncdf 615 9 infected infect VBN cord-001397-nrq4ncdf 615 10 HL-1 HL-1 NNP cord-001397-nrq4ncdf 615 11 cells cell NNS cord-001397-nrq4ncdf 615 12 occurs occur VBZ cord-001397-nrq4ncdf 615 13 rapidly rapidly RB cord-001397-nrq4ncdf 615 14 from from IN cord-001397-nrq4ncdf 615 15 60 60 CD cord-001397-nrq4ncdf 615 16 % % NN cord-001397-nrq4ncdf 615 17 following follow VBG cord-001397-nrq4ncdf 615 18 three three CD cord-001397-nrq4ncdf 615 19 passages passage NNS cord-001397-nrq4ncdf 615 20 to to IN cord-001397-nrq4ncdf 615 21 90 90 CD cord-001397-nrq4ncdf 615 22 % % NN cord-001397-nrq4ncdf 615 23 at at IN cord-001397-nrq4ncdf 615 24 passage passage NN cord-001397-nrq4ncdf 615 25 8 8 CD cord-001397-nrq4ncdf 615 26 ( ( -LRB- cord-001397-nrq4ncdf 615 27 Varatharaj Varatharaj NNP cord-001397-nrq4ncdf 615 28 , , , cord-001397-nrq4ncdf 615 29 2010 2010 CD cord-001397-nrq4ncdf 615 30 ) ) -RRB- cord-001397-nrq4ncdf 615 31 . . . cord-001397-nrq4ncdf 616 1 The the DT cord-001397-nrq4ncdf 616 2 importance importance NN cord-001397-nrq4ncdf 616 3 of of IN cord-001397-nrq4ncdf 616 4 CAR car NN cord-001397-nrq4ncdf 616 5 down down IN cord-001397-nrq4ncdf 616 6 - - HYPH cord-001397-nrq4ncdf 616 7 regulation regulation NN cord-001397-nrq4ncdf 616 8 is be VBZ cord-001397-nrq4ncdf 616 9 emphasized emphasize VBN cord-001397-nrq4ncdf 616 10 by by IN cord-001397-nrq4ncdf 616 11 the the DT cord-001397-nrq4ncdf 616 12 fact fact NN cord-001397-nrq4ncdf 616 13 that that IN cord-001397-nrq4ncdf 616 14 in in IN cord-001397-nrq4ncdf 616 15 vitro vitro FW cord-001397-nrq4ncdf 616 16 CAR car NN cord-001397-nrq4ncdf 616 17 knockout knockout NN cord-001397-nrq4ncdf 616 18 results result NNS cord-001397-nrq4ncdf 616 19 in in IN cord-001397-nrq4ncdf 616 20 reduced reduce VBN cord-001397-nrq4ncdf 616 21 viral viral JJ cord-001397-nrq4ncdf 616 22 replication replication NN cord-001397-nrq4ncdf 616 23 as as RB cord-001397-nrq4ncdf 616 24 well well RB cord-001397-nrq4ncdf 616 25 as as IN cord-001397-nrq4ncdf 616 26 virus virus NN cord-001397-nrq4ncdf 616 27 - - HYPH cord-001397-nrq4ncdf 616 28 induced induce VBN cord-001397-nrq4ncdf 616 29 cell cell NN cord-001397-nrq4ncdf 616 30 lysis lysis NN cord-001397-nrq4ncdf 616 31 ( ( -LRB- cord-001397-nrq4ncdf 616 32 Tomori Tomori NNP cord-001397-nrq4ncdf 616 33 , , , cord-001397-nrq4ncdf 616 34 2004 2004 CD cord-001397-nrq4ncdf 616 35 ; ; : cord-001397-nrq4ncdf 616 36 Gulati Gulati NNP cord-001397-nrq4ncdf 616 37 & & CC cord-001397-nrq4ncdf 616 38 Maheshwari Maheshwari NNP cord-001397-nrq4ncdf 616 39 , , , cord-001397-nrq4ncdf 616 40 2007 2007 CD cord-001397-nrq4ncdf 616 41 ) ) -RRB- cord-001397-nrq4ncdf 616 42 . . . cord-001397-nrq4ncdf 617 1 These these DT cord-001397-nrq4ncdf 617 2 selected select VBN cord-001397-nrq4ncdf 617 3 examples example NNS cord-001397-nrq4ncdf 617 4 simply simply RB cord-001397-nrq4ncdf 617 5 highlight highlight VBP cord-001397-nrq4ncdf 617 6 the the DT cord-001397-nrq4ncdf 617 7 diversity diversity NN cord-001397-nrq4ncdf 617 8 of of IN cord-001397-nrq4ncdf 617 9 possible possible JJ cord-001397-nrq4ncdf 617 10 mechanisms mechanism NNS cord-001397-nrq4ncdf 617 11 that that WDT cord-001397-nrq4ncdf 617 12 the the DT cord-001397-nrq4ncdf 617 13 VBFV VBFV NNP cord-001397-nrq4ncdf 617 14 might may MD cord-001397-nrq4ncdf 617 15 harness harness VB cord-001397-nrq4ncdf 617 16 in in IN cord-001397-nrq4ncdf 617 17 initiating initiate VBG cord-001397-nrq4ncdf 617 18 and and CC cord-001397-nrq4ncdf 617 19 maintaining maintain VBG cord-001397-nrq4ncdf 617 20 persistence persistence NN cord-001397-nrq4ncdf 617 21 and and CC cord-001397-nrq4ncdf 617 22 provide provide VB cord-001397-nrq4ncdf 617 23 concepts concept NNS cord-001397-nrq4ncdf 617 24 that that WDT cord-001397-nrq4ncdf 617 25 might may MD cord-001397-nrq4ncdf 617 26 be be VB cord-001397-nrq4ncdf 617 27 useful useful JJ cord-001397-nrq4ncdf 617 28 to to TO cord-001397-nrq4ncdf 617 29 investigate investigate VB cord-001397-nrq4ncdf 617 30 . . . cord-001397-nrq4ncdf 618 1 In in IN cord-001397-nrq4ncdf 618 2 the the DT cord-001397-nrq4ncdf 618 3 preceding precede VBG cord-001397-nrq4ncdf 618 4 sections section NNS cord-001397-nrq4ncdf 618 5 , , , cord-001397-nrq4ncdf 618 6 we -PRON- PRP cord-001397-nrq4ncdf 618 7 surveyed survey VBD cord-001397-nrq4ncdf 618 8 a a DT cord-001397-nrq4ncdf 618 9 substantial substantial JJ cord-001397-nrq4ncdf 618 10 literature literature NN cord-001397-nrq4ncdf 618 11 with with IN cord-001397-nrq4ncdf 618 12 relevance relevance NN cord-001397-nrq4ncdf 618 13 to to IN cord-001397-nrq4ncdf 618 14 various various JJ cord-001397-nrq4ncdf 618 15 aspects aspect NNS cord-001397-nrq4ncdf 618 16 of of IN cord-001397-nrq4ncdf 618 17 flavivirus flavivirus JJ cord-001397-nrq4ncdf 618 18 persistence persistence NN cord-001397-nrq4ncdf 618 19 . . . cord-001397-nrq4ncdf 619 1 Elucidation elucidation NN cord-001397-nrq4ncdf 619 2 of of IN cord-001397-nrq4ncdf 619 3 how how WRB cord-001397-nrq4ncdf 619 4 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 619 5 persist persist VBP cord-001397-nrq4ncdf 619 6 in in IN cord-001397-nrq4ncdf 619 7 humans human NNS cord-001397-nrq4ncdf 619 8 could could MD cord-001397-nrq4ncdf 619 9 help help VB cord-001397-nrq4ncdf 619 10 toward toward IN cord-001397-nrq4ncdf 619 11 the the DT cord-001397-nrq4ncdf 619 12 development development NN cord-001397-nrq4ncdf 619 13 of of IN cord-001397-nrq4ncdf 619 14 therapeutic therapeutic JJ cord-001397-nrq4ncdf 619 15 interventions intervention NNS cord-001397-nrq4ncdf 619 16 that that WDT cord-001397-nrq4ncdf 619 17 could could MD cord-001397-nrq4ncdf 619 18 alleviate alleviate VB cord-001397-nrq4ncdf 619 19 morbidity morbidity NN cord-001397-nrq4ncdf 619 20 and and CC cord-001397-nrq4ncdf 619 21 budgetary budgetary JJ cord-001397-nrq4ncdf 619 22 burdens burden NNS cord-001397-nrq4ncdf 619 23 associated associate VBN cord-001397-nrq4ncdf 619 24 with with IN cord-001397-nrq4ncdf 619 25 neurological neurological JJ cord-001397-nrq4ncdf 619 26 sequelae sequela NNS cord-001397-nrq4ncdf 619 27 . . . cord-001397-nrq4ncdf 620 1 Despite despite IN cord-001397-nrq4ncdf 620 2 the the DT cord-001397-nrq4ncdf 620 3 current current JJ cord-001397-nrq4ncdf 620 4 knowledge knowledge NN cord-001397-nrq4ncdf 620 5 , , , cord-001397-nrq4ncdf 620 6 a a DT cord-001397-nrq4ncdf 620 7 relative relative JJ cord-001397-nrq4ncdf 620 8 dearth dearth NN cord-001397-nrq4ncdf 620 9 of of IN cord-001397-nrq4ncdf 620 10 knowledge knowledge NN cord-001397-nrq4ncdf 620 11 still still RB cord-001397-nrq4ncdf 620 12 exists exist VBZ cord-001397-nrq4ncdf 620 13 , , , cord-001397-nrq4ncdf 620 14 and and CC cord-001397-nrq4ncdf 620 15 additional additional JJ cord-001397-nrq4ncdf 620 16 research research NN cord-001397-nrq4ncdf 620 17 is be VBZ cord-001397-nrq4ncdf 620 18 merited merit VBN cord-001397-nrq4ncdf 620 19 on on IN cord-001397-nrq4ncdf 620 20 these these DT cord-001397-nrq4ncdf 620 21 significant significant JJ cord-001397-nrq4ncdf 620 22 human human JJ cord-001397-nrq4ncdf 620 23 pathogens pathogen NNS cord-001397-nrq4ncdf 620 24 . . . cord-001397-nrq4ncdf 621 1 For for IN cord-001397-nrq4ncdf 621 2 instance instance NN cord-001397-nrq4ncdf 621 3 , , , cord-001397-nrq4ncdf 621 4 the the DT cord-001397-nrq4ncdf 621 5 definition definition NN cord-001397-nrq4ncdf 621 6 of of IN cord-001397-nrq4ncdf 621 7 specific specific JJ cord-001397-nrq4ncdf 621 8 viral viral JJ cord-001397-nrq4ncdf 621 9 proteins protein NNS cord-001397-nrq4ncdf 621 10 and and CC cord-001397-nrq4ncdf 621 11 cellular cellular JJ cord-001397-nrq4ncdf 621 12 factors factor NNS cord-001397-nrq4ncdf 621 13 and and CC cord-001397-nrq4ncdf 621 14 their -PRON- PRP$ cord-001397-nrq4ncdf 621 15 interactions interaction NNS cord-001397-nrq4ncdf 621 16 in in IN cord-001397-nrq4ncdf 621 17 the the DT cord-001397-nrq4ncdf 621 18 establishment establishment NN cord-001397-nrq4ncdf 621 19 and and CC cord-001397-nrq4ncdf 621 20 maintenance maintenance NN cord-001397-nrq4ncdf 621 21 of of IN cord-001397-nrq4ncdf 621 22 persistent persistent JJ cord-001397-nrq4ncdf 621 23 infection infection NN cord-001397-nrq4ncdf 621 24 is be VBZ cord-001397-nrq4ncdf 621 25 very very RB cord-001397-nrq4ncdf 621 26 limited limited JJ cord-001397-nrq4ncdf 621 27 . . . cord-001397-nrq4ncdf 622 1 As as IN cord-001397-nrq4ncdf 622 2 noted note VBN cord-001397-nrq4ncdf 622 3 , , , cord-001397-nrq4ncdf 622 4 for for IN cord-001397-nrq4ncdf 622 5 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 622 6 to to TO cord-001397-nrq4ncdf 622 7 persist persist VB cord-001397-nrq4ncdf 622 8 in in IN cord-001397-nrq4ncdf 622 9 infected infected JJ cord-001397-nrq4ncdf 622 10 cells cell NNS cord-001397-nrq4ncdf 622 11 in in IN cord-001397-nrq4ncdf 622 12 culture culture NN cord-001397-nrq4ncdf 622 13 or or CC cord-001397-nrq4ncdf 622 14 in in IN cord-001397-nrq4ncdf 622 15 vivo vivo NN cord-001397-nrq4ncdf 622 16 , , , cord-001397-nrq4ncdf 622 17 specific specific JJ cord-001397-nrq4ncdf 622 18 host host NN cord-001397-nrq4ncdf 622 19 defenses defense NNS cord-001397-nrq4ncdf 622 20 need need VBP cord-001397-nrq4ncdf 622 21 to to TO cord-001397-nrq4ncdf 622 22 be be VB cord-001397-nrq4ncdf 622 23 evaded evade VBN cord-001397-nrq4ncdf 622 24 or or CC cord-001397-nrq4ncdf 622 25 controlled control VBN cord-001397-nrq4ncdf 622 26 . . . cord-001397-nrq4ncdf 623 1 The the DT cord-001397-nrq4ncdf 623 2 role role NN cord-001397-nrq4ncdf 623 3 of of IN cord-001397-nrq4ncdf 623 4 NS5 NS5 NNP cord-001397-nrq4ncdf 623 5 as as IN cord-001397-nrq4ncdf 623 6 an an DT cord-001397-nrq4ncdf 623 7 interferon interferon NN cord-001397-nrq4ncdf 623 8 antagonist antagonist NN cord-001397-nrq4ncdf 623 9 ( ( -LRB- cord-001397-nrq4ncdf 623 10 especially especially RB cord-001397-nrq4ncdf 623 11 in in IN cord-001397-nrq4ncdf 623 12 TBFVs tbfvs NN cord-001397-nrq4ncdf 623 13 ) ) -RRB- cord-001397-nrq4ncdf 623 14 has have VBZ cord-001397-nrq4ncdf 623 15 been be VBN cord-001397-nrq4ncdf 623 16 established establish VBN cord-001397-nrq4ncdf 624 1 ( ( -LRB- cord-001397-nrq4ncdf 624 2 Best good JJS cord-001397-nrq4ncdf 624 3 et et FW cord-001397-nrq4ncdf 624 4 al al NNP cord-001397-nrq4ncdf 624 5 . . NNP cord-001397-nrq4ncdf 624 6 , , , cord-001397-nrq4ncdf 624 7 2005 2005 CD cord-001397-nrq4ncdf 624 8 ) ) -RRB- cord-001397-nrq4ncdf 624 9 , , , cord-001397-nrq4ncdf 624 10 but but CC cord-001397-nrq4ncdf 624 11 its -PRON- PRP$ cord-001397-nrq4ncdf 624 12 IFN IFN NNP cord-001397-nrq4ncdf 624 13 antagonism antagonism NN cord-001397-nrq4ncdf 624 14 in in IN cord-001397-nrq4ncdf 624 15 the the DT cord-001397-nrq4ncdf 624 16 context context NN cord-001397-nrq4ncdf 624 17 of of IN cord-001397-nrq4ncdf 624 18 VBFV VBFV NNP cord-001397-nrq4ncdf 624 19 persistence persistence NN cord-001397-nrq4ncdf 624 20 has have VBZ cord-001397-nrq4ncdf 624 21 not not RB cord-001397-nrq4ncdf 624 22 been be VBN cord-001397-nrq4ncdf 624 23 fully fully RB cord-001397-nrq4ncdf 624 24 explored explore VBN cord-001397-nrq4ncdf 624 25 . . . cord-001397-nrq4ncdf 625 1 This this DT cord-001397-nrq4ncdf 625 2 is be VBZ cord-001397-nrq4ncdf 625 3 also also RB cord-001397-nrq4ncdf 625 4 true true JJ cord-001397-nrq4ncdf 625 5 for for IN cord-001397-nrq4ncdf 625 6 MBFV MBFV NNP cord-001397-nrq4ncdf 626 1 NS4B NS4B NNP cord-001397-nrq4ncdf 626 2 , , , cord-001397-nrq4ncdf 626 3 which which WDT cord-001397-nrq4ncdf 626 4 impairs impair VBZ cord-001397-nrq4ncdf 626 5 IFN IFN NNP cord-001397-nrq4ncdf 626 6 - - HYPH cord-001397-nrq4ncdf 626 7 a a NNP cord-001397-nrq4ncdf 626 8 / / SYM cord-001397-nrq4ncdf 626 9 b b NN cord-001397-nrq4ncdf 626 10 induction induction NN cord-001397-nrq4ncdf 626 11 via via IN cord-001397-nrq4ncdf 626 12 JAK JAK NNP cord-001397-nrq4ncdf 626 13 / / SYM cord-001397-nrq4ncdf 626 14 STAT stat NN cord-001397-nrq4ncdf 626 15 signaling signal VBG cord-001397-nrq4ncdf 626 16 ( ( -LRB- cord-001397-nrq4ncdf 626 17 Muñoz Muñoz NNP cord-001397-nrq4ncdf 626 18 - - HYPH cord-001397-nrq4ncdf 626 19 Jord Jord NNP cord-001397-nrq4ncdf 626 20 an an NNP cord-001397-nrq4ncdf 626 21 et et FW cord-001397-nrq4ncdf 626 22 al al NNP cord-001397-nrq4ncdf 626 23 . . NNP cord-001397-nrq4ncdf 626 24 , , , cord-001397-nrq4ncdf 626 25 2005 2005 CD cord-001397-nrq4ncdf 626 26 ) ) -RRB- cord-001397-nrq4ncdf 626 27 . . . cord-001397-nrq4ncdf 627 1 Furthermore furthermore RB cord-001397-nrq4ncdf 627 2 , , , cord-001397-nrq4ncdf 627 3 mutations mutation NNS cord-001397-nrq4ncdf 627 4 in in IN cord-001397-nrq4ncdf 627 5 NS2A NS2A NNP cord-001397-nrq4ncdf 627 6 of of IN cord-001397-nrq4ncdf 627 7 Kunjin Kunjin NNP cord-001397-nrq4ncdf 627 8 virus virus NN cord-001397-nrq4ncdf 627 9 result result NN cord-001397-nrq4ncdf 627 10 in in IN cord-001397-nrq4ncdf 627 11 increased increase VBN cord-001397-nrq4ncdf 627 12 IFN IFN NNP cord-001397-nrq4ncdf 627 13 levels level NNS cord-001397-nrq4ncdf 627 14 , , , cord-001397-nrq4ncdf 627 15 suggesting suggest VBG cord-001397-nrq4ncdf 627 16 an an DT cord-001397-nrq4ncdf 627 17 IFN IFN NNP cord-001397-nrq4ncdf 627 18 antagonistic antagonistic JJ cord-001397-nrq4ncdf 627 19 role role NN cord-001397-nrq4ncdf 627 20 of of IN cord-001397-nrq4ncdf 627 21 NS2A NS2A NNP cord-001397-nrq4ncdf 628 1 ( ( -LRB- cord-001397-nrq4ncdf 628 2 Liu Liu NNP cord-001397-nrq4ncdf 628 3 et et NNP cord-001397-nrq4ncdf 628 4 al al NNP cord-001397-nrq4ncdf 628 5 . . NNP cord-001397-nrq4ncdf 628 6 , , , cord-001397-nrq4ncdf 628 7 2004 2004 CD cord-001397-nrq4ncdf 628 8 ) ) -RRB- cord-001397-nrq4ncdf 628 9 . . . cord-001397-nrq4ncdf 629 1 Intriguing intriguing JJ cord-001397-nrq4ncdf 629 2 is be VBZ cord-001397-nrq4ncdf 629 3 the the DT cord-001397-nrq4ncdf 629 4 fact fact NN cord-001397-nrq4ncdf 629 5 that that IN cord-001397-nrq4ncdf 629 6 VBFVs vbfv NNS cord-001397-nrq4ncdf 629 7 antagonize antagonize VBP cord-001397-nrq4ncdf 629 8 IFN IFN NNP cord-001397-nrq4ncdf 629 9 even even RB cord-001397-nrq4ncdf 629 10 in in IN cord-001397-nrq4ncdf 629 11 the the DT cord-001397-nrq4ncdf 629 12 cells cell NNS cord-001397-nrq4ncdf 629 13 that that WDT cord-001397-nrq4ncdf 629 14 will will MD cord-001397-nrq4ncdf 629 15 eventually eventually RB cord-001397-nrq4ncdf 629 16 die die VB cord-001397-nrq4ncdf 629 17 in in IN cord-001397-nrq4ncdf 629 18 the the DT cord-001397-nrq4ncdf 629 19 acute acute JJ cord-001397-nrq4ncdf 629 20 phase phase NN cord-001397-nrq4ncdf 629 21 of of IN cord-001397-nrq4ncdf 629 22 infection infection NN cord-001397-nrq4ncdf 629 23 . . . cord-001397-nrq4ncdf 630 1 As as IN cord-001397-nrq4ncdf 630 2 IFN IFN NNP cord-001397-nrq4ncdf 630 3 antagonism antagonism NN cord-001397-nrq4ncdf 630 4 seems seem VBZ cord-001397-nrq4ncdf 630 5 to to TO cord-001397-nrq4ncdf 630 6 be be VB cord-001397-nrq4ncdf 630 7 important important JJ cord-001397-nrq4ncdf 630 8 for for IN cord-001397-nrq4ncdf 630 9 HCV HCV NNP cord-001397-nrq4ncdf 630 10 , , , cord-001397-nrq4ncdf 630 11 interrogating interrogate VBG cord-001397-nrq4ncdf 630 12 the the DT cord-001397-nrq4ncdf 630 13 role role NN cord-001397-nrq4ncdf 630 14 of of IN cord-001397-nrq4ncdf 630 15 these these DT cord-001397-nrq4ncdf 630 16 VBFV vbfv NN cord-001397-nrq4ncdf 630 17 proteins protein NNS cord-001397-nrq4ncdf 630 18 to to TO cord-001397-nrq4ncdf 630 19 ascertain ascertain VB cord-001397-nrq4ncdf 630 20 their -PRON- PRP$ cord-001397-nrq4ncdf 630 21 role role NN cord-001397-nrq4ncdf 630 22 in in IN cord-001397-nrq4ncdf 630 23 the the DT cord-001397-nrq4ncdf 630 24 establishment establishment NN cord-001397-nrq4ncdf 630 25 of of IN cord-001397-nrq4ncdf 630 26 viral viral JJ cord-001397-nrq4ncdf 630 27 persistence persistence NN cord-001397-nrq4ncdf 630 28 will will MD cord-001397-nrq4ncdf 630 29 be be VB cord-001397-nrq4ncdf 630 30 critical critical JJ cord-001397-nrq4ncdf 630 31 . . . cord-001397-nrq4ncdf 631 1 The the DT cord-001397-nrq4ncdf 631 2 specific specific JJ cord-001397-nrq4ncdf 631 3 mammalian mammalian JJ cord-001397-nrq4ncdf 631 4 host host NN cord-001397-nrq4ncdf 631 5 immune immune JJ cord-001397-nrq4ncdf 631 6 responses response NNS cord-001397-nrq4ncdf 631 7 that that WDT cord-001397-nrq4ncdf 631 8 are be VBP cord-001397-nrq4ncdf 631 9 evaded evade VBN cord-001397-nrq4ncdf 631 10 or or CC cord-001397-nrq4ncdf 631 11 controlled control VBN cord-001397-nrq4ncdf 631 12 also also RB cord-001397-nrq4ncdf 631 13 need need VBP cord-001397-nrq4ncdf 631 14 to to TO cord-001397-nrq4ncdf 631 15 be be VB cord-001397-nrq4ncdf 631 16 identified identify VBN cord-001397-nrq4ncdf 631 17 precisely precisely RB cord-001397-nrq4ncdf 631 18 . . . cord-001397-nrq4ncdf 632 1 Although although IN cord-001397-nrq4ncdf 632 2 overexpression overexpression NN cord-001397-nrq4ncdf 632 3 of of IN cord-001397-nrq4ncdf 632 4 Bcl-2 Bcl-2 NNP cord-001397-nrq4ncdf 632 5 in in IN cord-001397-nrq4ncdf 632 6 BHK BHK NNP cord-001397-nrq4ncdf 632 7 and and CC cord-001397-nrq4ncdf 632 8 CHO CHO NNP cord-001397-nrq4ncdf 632 9 cells cell NNS cord-001397-nrq4ncdf 632 10 resulted result VBD cord-001397-nrq4ncdf 632 11 in in IN cord-001397-nrq4ncdf 632 12 the the DT cord-001397-nrq4ncdf 632 13 inhibition inhibition NN cord-001397-nrq4ncdf 632 14 of of IN cord-001397-nrq4ncdf 632 15 apoptosis apoptosis NN cord-001397-nrq4ncdf 632 16 and and CC cord-001397-nrq4ncdf 632 17 JEV JEV NNP cord-001397-nrq4ncdf 632 18 persistence persistence NN cord-001397-nrq4ncdf 632 19 , , , cord-001397-nrq4ncdf 632 20 a a DT cord-001397-nrq4ncdf 632 21 direct direct JJ cord-001397-nrq4ncdf 632 22 viral viral JJ cord-001397-nrq4ncdf 632 23 effect effect NN cord-001397-nrq4ncdf 632 24 on on IN cord-001397-nrq4ncdf 632 25 Bcl-2 Bcl-2 NNP cord-001397-nrq4ncdf 632 26 was be VBD cord-001397-nrq4ncdf 632 27 not not RB cord-001397-nrq4ncdf 632 28 determined determine VBN cord-001397-nrq4ncdf 632 29 ( ( -LRB- cord-001397-nrq4ncdf 633 1 Liao Liao NNP cord-001397-nrq4ncdf 633 2 et et NNP cord-001397-nrq4ncdf 633 3 al al NNP cord-001397-nrq4ncdf 633 4 . . NNP cord-001397-nrq4ncdf 633 5 , , , cord-001397-nrq4ncdf 633 6 1998 1998 CD cord-001397-nrq4ncdf 633 7 ) ) -RRB- cord-001397-nrq4ncdf 633 8 . . . cord-001397-nrq4ncdf 634 1 It -PRON- PRP cord-001397-nrq4ncdf 634 2 would would MD cord-001397-nrq4ncdf 634 3 be be VB cord-001397-nrq4ncdf 634 4 useful useful JJ cord-001397-nrq4ncdf 634 5 to to TO cord-001397-nrq4ncdf 634 6 understand understand VB cord-001397-nrq4ncdf 634 7 which which WDT cord-001397-nrq4ncdf 634 8 , , , cord-001397-nrq4ncdf 634 9 and and CC cord-001397-nrq4ncdf 634 10 how how WRB cord-001397-nrq4ncdf 634 11 , , , cord-001397-nrq4ncdf 634 12 VBFV VBFV NNP cord-001397-nrq4ncdf 634 13 proteins protein NNS cord-001397-nrq4ncdf 634 14 interact interact VBP cord-001397-nrq4ncdf 634 15 with with IN cord-001397-nrq4ncdf 634 16 the the DT cord-001397-nrq4ncdf 634 17 Bcl-2 Bcl-2 NNP cord-001397-nrq4ncdf 634 18 pathway pathway NN cord-001397-nrq4ncdf 634 19 . . . cord-001397-nrq4ncdf 635 1 Indeed indeed RB cord-001397-nrq4ncdf 635 2 , , , cord-001397-nrq4ncdf 635 3 other other JJ cord-001397-nrq4ncdf 635 4 host host NN cord-001397-nrq4ncdf 635 5 pathways pathway NNS cord-001397-nrq4ncdf 635 6 could could MD cord-001397-nrq4ncdf 635 7 be be VB cord-001397-nrq4ncdf 635 8 involved involve VBN cord-001397-nrq4ncdf 635 9 and and CC cord-001397-nrq4ncdf 635 10 need need VBP cord-001397-nrq4ncdf 635 11 to to TO cord-001397-nrq4ncdf 635 12 be be VB cord-001397-nrq4ncdf 635 13 elucidated elucidate VBN cord-001397-nrq4ncdf 635 14 further further RB cord-001397-nrq4ncdf 635 15 . . . cord-001397-nrq4ncdf 636 1 The the DT cord-001397-nrq4ncdf 636 2 exact exact JJ cord-001397-nrq4ncdf 636 3 correlates correlate NNS cord-001397-nrq4ncdf 636 4 of of IN cord-001397-nrq4ncdf 636 5 persistent persistent JJ cord-001397-nrq4ncdf 636 6 flavivirus flavivirus JJ cord-001397-nrq4ncdf 636 7 infection infection NN cord-001397-nrq4ncdf 636 8 in in IN cord-001397-nrq4ncdf 636 9 the the DT cord-001397-nrq4ncdf 636 10 arachnid arachnid NN cord-001397-nrq4ncdf 636 11 or or CC cord-001397-nrq4ncdf 636 12 insect insect NN cord-001397-nrq4ncdf 636 13 vector vector NN cord-001397-nrq4ncdf 636 14 host host NN cord-001397-nrq4ncdf 636 15 also also RB cord-001397-nrq4ncdf 636 16 need need VBP cord-001397-nrq4ncdf 636 17 to to TO cord-001397-nrq4ncdf 636 18 be be VB cord-001397-nrq4ncdf 636 19 determined determine VBN cord-001397-nrq4ncdf 636 20 . . . cord-001397-nrq4ncdf 637 1 The the DT cord-001397-nrq4ncdf 637 2 biology biology NN cord-001397-nrq4ncdf 637 3 of of IN cord-001397-nrq4ncdf 637 4 ticks tick NNS cord-001397-nrq4ncdf 637 5 and and CC cord-001397-nrq4ncdf 637 6 that that IN cord-001397-nrq4ncdf 637 7 of of IN cord-001397-nrq4ncdf 637 8 mammals mammal NNS cord-001397-nrq4ncdf 637 9 is be VBZ cord-001397-nrq4ncdf 637 10 completely completely RB cord-001397-nrq4ncdf 637 11 different different JJ cord-001397-nrq4ncdf 637 12 . . . cord-001397-nrq4ncdf 638 1 For for IN cord-001397-nrq4ncdf 638 2 ixodid ixodid NNP cord-001397-nrq4ncdf 638 3 tick tick NN cord-001397-nrq4ncdf 638 4 vectors vector NNS cord-001397-nrq4ncdf 638 5 , , , cord-001397-nrq4ncdf 638 6 identifying identify VBG cord-001397-nrq4ncdf 638 7 genetic genetic JJ cord-001397-nrq4ncdf 638 8 or or CC cord-001397-nrq4ncdf 638 9 biological biological JJ cord-001397-nrq4ncdf 638 10 targets target NNS cord-001397-nrq4ncdf 638 11 that that WDT cord-001397-nrq4ncdf 638 12 could could MD cord-001397-nrq4ncdf 638 13 play play VB cord-001397-nrq4ncdf 638 14 a a DT cord-001397-nrq4ncdf 638 15 role role NN cord-001397-nrq4ncdf 638 16 in in IN cord-001397-nrq4ncdf 638 17 viral viral JJ cord-001397-nrq4ncdf 638 18 persistence persistence NN cord-001397-nrq4ncdf 638 19 is be VBZ cord-001397-nrq4ncdf 638 20 imperative imperative JJ cord-001397-nrq4ncdf 638 21 . . . cord-001397-nrq4ncdf 639 1 These these DT cord-001397-nrq4ncdf 639 2 vector vector NN cord-001397-nrq4ncdf 639 3 mechanisms mechanism NNS cord-001397-nrq4ncdf 639 4 might may MD cord-001397-nrq4ncdf 639 5 find find VB cord-001397-nrq4ncdf 639 6 application application NN cord-001397-nrq4ncdf 639 7 , , , cord-001397-nrq4ncdf 639 8 when when WRB cord-001397-nrq4ncdf 639 9 known know VBN cord-001397-nrq4ncdf 639 10 , , , cord-001397-nrq4ncdf 639 11 in in IN cord-001397-nrq4ncdf 639 12 efforts effort NNS cord-001397-nrq4ncdf 639 13 to to TO cord-001397-nrq4ncdf 639 14 control control VB cord-001397-nrq4ncdf 639 15 natural natural JJ cord-001397-nrq4ncdf 639 16 flavivirus flavivirus JJ cord-001397-nrq4ncdf 639 17 persistence persistence NN cord-001397-nrq4ncdf 639 18 cycles cycle NNS cord-001397-nrq4ncdf 639 19 in in IN cord-001397-nrq4ncdf 639 20 ticks tick NNS cord-001397-nrq4ncdf 639 21 . . . cord-001397-nrq4ncdf 640 1 The the DT cord-001397-nrq4ncdf 640 2 mechanism(s mechanism(s NNP cord-001397-nrq4ncdf 640 3 ) ) -RRB- cord-001397-nrq4ncdf 640 4 could could MD cord-001397-nrq4ncdf 640 5 involve involve VB cord-001397-nrq4ncdf 640 6 viral viral JJ cord-001397-nrq4ncdf 640 7 genetic genetic JJ cord-001397-nrq4ncdf 640 8 changes change NNS cord-001397-nrq4ncdf 640 9 , , , cord-001397-nrq4ncdf 640 10 such such JJ cord-001397-nrq4ncdf 640 11 as as IN cord-001397-nrq4ncdf 640 12 specific specific JJ cord-001397-nrq4ncdf 640 13 mutations mutation NNS cord-001397-nrq4ncdf 640 14 that that WDT cord-001397-nrq4ncdf 640 15 may may MD cord-001397-nrq4ncdf 640 16 render render VB cord-001397-nrq4ncdf 640 17 the the DT cord-001397-nrq4ncdf 640 18 virus virus NN cord-001397-nrq4ncdf 640 19 less less RBR cord-001397-nrq4ncdf 640 20 detectable detectable JJ cord-001397-nrq4ncdf 640 21 in in IN cord-001397-nrq4ncdf 640 22 infected infected JJ cord-001397-nrq4ncdf 640 23 cells cell NNS cord-001397-nrq4ncdf 640 24 . . . cord-001397-nrq4ncdf 641 1 An an DT cord-001397-nrq4ncdf 641 2 important important JJ cord-001397-nrq4ncdf 641 3 question question NN cord-001397-nrq4ncdf 641 4 for for IN cord-001397-nrq4ncdf 641 5 transmission transmission NN cord-001397-nrq4ncdf 641 6 and and CC cord-001397-nrq4ncdf 641 7 viral viral JJ cord-001397-nrq4ncdf 641 8 evolution evolution NN cord-001397-nrq4ncdf 641 9 dynamics dynamic NNS cord-001397-nrq4ncdf 641 10 is be VBZ cord-001397-nrq4ncdf 641 11 why why WRB cord-001397-nrq4ncdf 641 12 arthropod arthropod JJ cord-001397-nrq4ncdf 641 13 vectors vector NNS cord-001397-nrq4ncdf 641 14 do do VBP cord-001397-nrq4ncdf 641 15 not not RB cord-001397-nrq4ncdf 641 16 appear appear VB cord-001397-nrq4ncdf 641 17 to to TO cord-001397-nrq4ncdf 641 18 be be VB cord-001397-nrq4ncdf 641 19 killed kill VBN cord-001397-nrq4ncdf 641 20 by by IN cord-001397-nrq4ncdf 641 21 viral viral JJ cord-001397-nrq4ncdf 641 22 infection infection NN cord-001397-nrq4ncdf 641 23 . . . cord-001397-nrq4ncdf 642 1 The the DT cord-001397-nrq4ncdf 642 2 down down JJ cord-001397-nrq4ncdf 642 3 - - HYPH cord-001397-nrq4ncdf 642 4 regulation regulation NN cord-001397-nrq4ncdf 642 5 of of IN cord-001397-nrq4ncdf 642 6 the the DT cord-001397-nrq4ncdf 642 7 CAR car NN cord-001397-nrq4ncdf 642 8 , , , cord-001397-nrq4ncdf 642 9 as as IN cord-001397-nrq4ncdf 642 10 a a DT cord-001397-nrq4ncdf 642 11 coevolutionary coevolutionary JJ cord-001397-nrq4ncdf 642 12 development development NN cord-001397-nrq4ncdf 642 13 that that WDT cord-001397-nrq4ncdf 642 14 favors favor VBZ cord-001397-nrq4ncdf 642 15 persistence persistence NN cord-001397-nrq4ncdf 642 16 , , , cord-001397-nrq4ncdf 642 17 is be VBZ cord-001397-nrq4ncdf 642 18 intriguing intriguing JJ cord-001397-nrq4ncdf 643 1 ( ( -LRB- cord-001397-nrq4ncdf 643 2 Fechner Fechner NNP cord-001397-nrq4ncdf 643 3 et et NNP cord-001397-nrq4ncdf 643 4 al al NNP cord-001397-nrq4ncdf 643 5 . . NNP cord-001397-nrq4ncdf 643 6 , , , cord-001397-nrq4ncdf 643 7 2007 2007 CD cord-001397-nrq4ncdf 643 8 ; ; : cord-001397-nrq4ncdf 643 9 Pinkert Pinkert NNP cord-001397-nrq4ncdf 643 10 et et NNP cord-001397-nrq4ncdf 643 11 al al NNP cord-001397-nrq4ncdf 643 12 . . NNP cord-001397-nrq4ncdf 643 13 , , , cord-001397-nrq4ncdf 643 14 2011 2011 CD cord-001397-nrq4ncdf 643 15 ) ) -RRB- cord-001397-nrq4ncdf 643 16 . . . cord-001397-nrq4ncdf 644 1 For for IN cord-001397-nrq4ncdf 644 2 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 644 3 , , , cord-001397-nrq4ncdf 644 4 various various JJ cord-001397-nrq4ncdf 644 5 receptors receptor NNS cord-001397-nrq4ncdf 644 6 have have VBP cord-001397-nrq4ncdf 644 7 been be VBN cord-001397-nrq4ncdf 644 8 identified identify VBN cord-001397-nrq4ncdf 644 9 as as IN cord-001397-nrq4ncdf 644 10 possible possible JJ cord-001397-nrq4ncdf 644 11 virus virus NN cord-001397-nrq4ncdf 644 12 - - HYPH cord-001397-nrq4ncdf 644 13 entry entry NN cord-001397-nrq4ncdf 644 14 mechanisms mechanism NNS cord-001397-nrq4ncdf 644 15 ( ( -LRB- cord-001397-nrq4ncdf 644 16 Smit Smit NNP cord-001397-nrq4ncdf 644 17 et et NNP cord-001397-nrq4ncdf 644 18 al al NNP cord-001397-nrq4ncdf 644 19 . . NNP cord-001397-nrq4ncdf 644 20 , , , cord-001397-nrq4ncdf 644 21 2011 2011 CD cord-001397-nrq4ncdf 644 22 ; ; : cord-001397-nrq4ncdf 644 23 Perera Perera NNP cord-001397-nrq4ncdf 644 24 - - HYPH cord-001397-nrq4ncdf 644 25 Lecoin Lecoin NNP cord-001397-nrq4ncdf 644 26 et et FW cord-001397-nrq4ncdf 644 27 al al NNP cord-001397-nrq4ncdf 644 28 . . . cord-001397-nrq4ncdf 645 1 , , , cord-001397-nrq4ncdf 645 2 2013 2013 CD cord-001397-nrq4ncdf 645 3 ) ) -RRB- cord-001397-nrq4ncdf 645 4 . . . cord-001397-nrq4ncdf 646 1 Investigations investigation NNS cord-001397-nrq4ncdf 646 2 into into IN cord-001397-nrq4ncdf 646 3 whether whether IN cord-001397-nrq4ncdf 646 4 there there EX cord-001397-nrq4ncdf 646 5 is be VBZ cord-001397-nrq4ncdf 646 6 a a DT cord-001397-nrq4ncdf 646 7 down down JJ cord-001397-nrq4ncdf 646 8 - - HYPH cord-001397-nrq4ncdf 646 9 regulation regulation NN cord-001397-nrq4ncdf 646 10 of of IN cord-001397-nrq4ncdf 646 11 flavivirus flavivirus JJ cord-001397-nrq4ncdf 646 12 receptors receptor NNS cord-001397-nrq4ncdf 646 13 , , , cord-001397-nrq4ncdf 646 14 as as IN cord-001397-nrq4ncdf 646 15 in in IN cord-001397-nrq4ncdf 646 16 Coxsackievirus Coxsackievirus NNP cord-001397-nrq4ncdf 646 17 persistence persistence NN cord-001397-nrq4ncdf 646 18 , , , cord-001397-nrq4ncdf 646 19 could could MD cord-001397-nrq4ncdf 646 20 be be VB cord-001397-nrq4ncdf 646 21 useful useful JJ cord-001397-nrq4ncdf 646 22 in in IN cord-001397-nrq4ncdf 646 23 defining define VBG cord-001397-nrq4ncdf 646 24 flavivirus flavivirus JJ cord-001397-nrq4ncdf 646 25 persistence persistence NN cord-001397-nrq4ncdf 646 26 mechanism mechanism NN cord-001397-nrq4ncdf 646 27 ( ( -LRB- cord-001397-nrq4ncdf 646 28 s s NN cord-001397-nrq4ncdf 646 29 ) ) -RRB- cord-001397-nrq4ncdf 646 30 . . . cord-001397-nrq4ncdf 647 1 Finally finally RB cord-001397-nrq4ncdf 647 2 , , , cord-001397-nrq4ncdf 647 3 the the DT cord-001397-nrq4ncdf 647 4 establishment establishment NN cord-001397-nrq4ncdf 647 5 of of IN cord-001397-nrq4ncdf 647 6 relevant relevant JJ cord-001397-nrq4ncdf 647 7 animal animal NN cord-001397-nrq4ncdf 647 8 models model NNS cord-001397-nrq4ncdf 647 9 of of IN cord-001397-nrq4ncdf 647 10 VBFV VBFV NNP cord-001397-nrq4ncdf 647 11 persistence persistence NN cord-001397-nrq4ncdf 647 12 will will MD cord-001397-nrq4ncdf 647 13 also also RB cord-001397-nrq4ncdf 647 14 be be VB cord-001397-nrq4ncdf 647 15 crucial crucial JJ cord-001397-nrq4ncdf 647 16 for for IN cord-001397-nrq4ncdf 647 17 understanding understand VBG cord-001397-nrq4ncdf 647 18 the the DT cord-001397-nrq4ncdf 647 19 dynamics dynamic NNS cord-001397-nrq4ncdf 647 20 of of IN cord-001397-nrq4ncdf 647 21 viral viral JJ cord-001397-nrq4ncdf 647 22 persistence persistence NN cord-001397-nrq4ncdf 647 23 and and CC cord-001397-nrq4ncdf 647 24 host host NN cord-001397-nrq4ncdf 647 25 responses response NNS cord-001397-nrq4ncdf 647 26 . . . cord-001397-nrq4ncdf 648 1 Animals animal NNS cord-001397-nrq4ncdf 648 2 that that WDT cord-001397-nrq4ncdf 648 3 serve serve VBP cord-001397-nrq4ncdf 648 4 as as IN cord-001397-nrq4ncdf 648 5 the the DT cord-001397-nrq4ncdf 648 6 natural natural JJ cord-001397-nrq4ncdf 648 7 host host NN cord-001397-nrq4ncdf 648 8 reservoirs reservoir NNS cord-001397-nrq4ncdf 648 9 will will MD cord-001397-nrq4ncdf 648 10 be be VB cord-001397-nrq4ncdf 648 11 key key JJ cord-001397-nrq4ncdf 648 12 in in IN cord-001397-nrq4ncdf 648 13 developing develop VBG cord-001397-nrq4ncdf 648 14 these these DT cord-001397-nrq4ncdf 648 15 models model NNS cord-001397-nrq4ncdf 648 16 . . . cord-001397-nrq4ncdf 649 1 Some some DT cord-001397-nrq4ncdf 649 2 models model NNS cord-001397-nrq4ncdf 649 3 have have VBP cord-001397-nrq4ncdf 649 4 been be VBN cord-001397-nrq4ncdf 649 5 established establish VBN cord-001397-nrq4ncdf 649 6 , , , cord-001397-nrq4ncdf 649 7 but but CC cord-001397-nrq4ncdf 649 8 may may MD cord-001397-nrq4ncdf 649 9 have have VB cord-001397-nrq4ncdf 649 10 failed fail VBN cord-001397-nrq4ncdf 649 11 to to TO cord-001397-nrq4ncdf 649 12 answer answer VB cord-001397-nrq4ncdf 649 13 ecologically ecologically RB cord-001397-nrq4ncdf 649 14 important important JJ cord-001397-nrq4ncdf 649 15 question question NN cord-001397-nrq4ncdf 649 16 . . . cord-001397-nrq4ncdf 650 1 Thus thus RB cord-001397-nrq4ncdf 650 2 , , , cord-001397-nrq4ncdf 650 3 future future JJ cord-001397-nrq4ncdf 650 4 work work NN cord-001397-nrq4ncdf 650 5 will will MD cord-001397-nrq4ncdf 650 6 combine combine VB cord-001397-nrq4ncdf 650 7 studies study NNS cord-001397-nrq4ncdf 650 8 encompassing encompass VBG cord-001397-nrq4ncdf 650 9 the the DT cord-001397-nrq4ncdf 650 10 biology biology NN cord-001397-nrq4ncdf 650 11 of of IN cord-001397-nrq4ncdf 650 12 VBFVs vbfv NNS cord-001397-nrq4ncdf 650 13 , , , cord-001397-nrq4ncdf 650 14 molecular molecular JJ cord-001397-nrq4ncdf 650 15 cell cell NN cord-001397-nrq4ncdf 650 16 biology biology NN cord-001397-nrq4ncdf 650 17 , , , cord-001397-nrq4ncdf 650 18 animal animal NN cord-001397-nrq4ncdf 650 19 models model NNS cord-001397-nrq4ncdf 650 20 , , , cord-001397-nrq4ncdf 650 21 and and CC cord-001397-nrq4ncdf 650 22 eventually eventually RB cord-001397-nrq4ncdf 650 23 virus virus NN cord-001397-nrq4ncdf 650 24 - - HYPH cord-001397-nrq4ncdf 650 25 host host NN cord-001397-nrq4ncdf 650 26 ecology ecology NN cord-001397-nrq4ncdf 650 27 . . . cord-001397-nrq4ncdf 650 28 _SP cord-001397-nrq4ncdf 651 1 Rodents rodent NNS cord-001397-nrq4ncdf 651 2 as as IN cord-001397-nrq4ncdf 651 3 sentinels sentinel NNS cord-001397-nrq4ncdf 651 4 for for IN cord-001397-nrq4ncdf 651 5 the the DT cord-001397-nrq4ncdf 651 6 prevalence prevalence NN cord-001397-nrq4ncdf 651 7 of of IN cord-001397-nrq4ncdf 651 8 tick tick NN cord-001397-nrq4ncdf 651 9 - - HYPH cord-001397-nrq4ncdf 651 10 borne bear VBN cord-001397-nrq4ncdf 651 11 encephalitis encephalitis JJ cord-001397-nrq4ncdf 651 12 virus virus NN cord-001397-nrq4ncdf 651 13 Polypyrimidine polypyrimidine JJ cord-001397-nrq4ncdf 651 14 - - HYPH cord-001397-nrq4ncdf 651 15 tract tract NN cord-001397-nrq4ncdf 651 16 - - HYPH cord-001397-nrq4ncdf 651 17 binding bind VBG cord-001397-nrq4ncdf 651 18 protein protein NN cord-001397-nrq4ncdf 651 19 is be VBZ cord-001397-nrq4ncdf 651 20 a a DT cord-001397-nrq4ncdf 651 21 component component NN cord-001397-nrq4ncdf 651 22 of of IN cord-001397-nrq4ncdf 651 23 the the DT cord-001397-nrq4ncdf 651 24 HCV HCV NNP cord-001397-nrq4ncdf 651 25 RNA RNA NNP cord-001397-nrq4ncdf 651 26 replication replication NN cord-001397-nrq4ncdf 651 27 complex complex NN cord-001397-nrq4ncdf 651 28 and and CC cord-001397-nrq4ncdf 651 29 necessary necessary JJ cord-001397-nrq4ncdf 651 30 for for IN cord-001397-nrq4ncdf 651 31 RNA RNA NNP cord-001397-nrq4ncdf 651 32 synthesis synthesis NN cord-001397-nrq4ncdf 651 33 Long long JJ cord-001397-nrq4ncdf 651 34 - - HYPH cord-001397-nrq4ncdf 651 35 range range NNP cord-001397-nrq4ncdf 651 36 RNA RNA NNP cord-001397-nrq4ncdf 651 37 - - HYPH cord-001397-nrq4ncdf 651 38 RNA RNA NNP cord-001397-nrq4ncdf 651 39 interactions interaction NNS cord-001397-nrq4ncdf 651 40 circularize circularize VBP cord-001397-nrq4ncdf 651 41 the the DT cord-001397-nrq4ncdf 651 42 dengue dengue NN cord-001397-nrq4ncdf 651 43 virus virus NN cord-001397-nrq4ncdf 651 44 genome genome NN cord-001397-nrq4ncdf 651 45 Prevalence prevalence NN cord-001397-nrq4ncdf 651 46 of of IN cord-001397-nrq4ncdf 651 47 West West NNP cord-001397-nrq4ncdf 651 48 Nile Nile NNP cord-001397-nrq4ncdf 651 49 virus virus NN cord-001397-nrq4ncdf 651 50 in in IN cord-001397-nrq4ncdf 651 51 tree tree NN cord-001397-nrq4ncdf 651 52 canopy canopy NN cord-001397-nrq4ncdf 651 53 - - HYPH cord-001397-nrq4ncdf 651 54 inhabiting inhabit VBG cord-001397-nrq4ncdf 651 55 Culex Culex NNP cord-001397-nrq4ncdf 651 56 pipiens pipien NNS cord-001397-nrq4ncdf 651 57 and and CC cord-001397-nrq4ncdf 651 58 associated associate VBD cord-001397-nrq4ncdf 651 59 mosquitoes mosquito NNS cord-001397-nrq4ncdf 651 60 Persistence Persistence NNP cord-001397-nrq4ncdf 651 61 of of IN cord-001397-nrq4ncdf 651 62 West West NNP cord-001397-nrq4ncdf 651 63 Nile Nile NNP cord-001397-nrq4ncdf 651 64 virus virus NN cord-001397-nrq4ncdf 651 65 in in IN cord-001397-nrq4ncdf 651 66 the the DT cord-001397-nrq4ncdf 651 67 central central JJ cord-001397-nrq4ncdf 651 68 nervous nervous JJ cord-001397-nrq4ncdf 651 69 system system NN cord-001397-nrq4ncdf 651 70 and and CC cord-001397-nrq4ncdf 651 71 periphery periphery NN cord-001397-nrq4ncdf 651 72 of of IN cord-001397-nrq4ncdf 651 73 mice mouse NNS cord-001397-nrq4ncdf 651 74 Crystal Crystal NNP cord-001397-nrq4ncdf 651 75 structure structure NN cord-001397-nrq4ncdf 651 76 of of IN cord-001397-nrq4ncdf 651 77 a a DT cord-001397-nrq4ncdf 651 78 novel novel JJ cord-001397-nrq4ncdf 651 79 conformational conformational JJ cord-001397-nrq4ncdf 651 80 state state NN cord-001397-nrq4ncdf 651 81 of of IN cord-001397-nrq4ncdf 651 82 the the DT cord-001397-nrq4ncdf 651 83 flavivirus flavivirus NNP cord-001397-nrq4ncdf 651 84 NS3 NS3 NNP cord-001397-nrq4ncdf 651 85 protein protein NN cord-001397-nrq4ncdf 651 86 : : : cord-001397-nrq4ncdf 651 87 implications implication NNS cord-001397-nrq4ncdf 651 88 for for IN cord-001397-nrq4ncdf 651 89 polyprotein polyprotein JJ cord-001397-nrq4ncdf 651 90 processing processing NN cord-001397-nrq4ncdf 651 91 and and CC cord-001397-nrq4ncdf 651 92 viral viral JJ cord-001397-nrq4ncdf 651 93 replication replication NN cord-001397-nrq4ncdf 652 1 Vascular vascular JJ cord-001397-nrq4ncdf 652 2 leakage leakage NN cord-001397-nrq4ncdf 652 3 in in IN cord-001397-nrq4ncdf 652 4 severe severe JJ cord-001397-nrq4ncdf 652 5 dengue dengue NN cord-001397-nrq4ncdf 652 6 virus virus NN cord-001397-nrq4ncdf 652 7 infections infection NNS cord-001397-nrq4ncdf 652 8 : : : cord-001397-nrq4ncdf 653 1 a a DT cord-001397-nrq4ncdf 653 2 potential potential JJ cord-001397-nrq4ncdf 653 3 role role NN cord-001397-nrq4ncdf 653 4 for for IN cord-001397-nrq4ncdf 653 5 the the DT cord-001397-nrq4ncdf 653 6 nonstructural nonstructural JJ cord-001397-nrq4ncdf 653 7 viral viral JJ cord-001397-nrq4ncdf 653 8 protein protein NN cord-001397-nrq4ncdf 653 9 NS1 NS1 NNS cord-001397-nrq4ncdf 653 10 and and CC cord-001397-nrq4ncdf 653 11 complement complement VB cord-001397-nrq4ncdf 653 12 Antagonism antagonism NN cord-001397-nrq4ncdf 653 13 of of IN cord-001397-nrq4ncdf 653 14 the the DT cord-001397-nrq4ncdf 653 15 complement complement JJ cord-001397-nrq4ncdf 653 16 component component NN cord-001397-nrq4ncdf 653 17 C4 c4 NN cord-001397-nrq4ncdf 653 18 by by IN cord-001397-nrq4ncdf 653 19 flavivirus flavivirus JJ cord-001397-nrq4ncdf 653 20 nonstructural nonstructural JJ cord-001397-nrq4ncdf 653 21 protein protein NN cord-001397-nrq4ncdf 653 22 NS1 NS1 NNS cord-001397-nrq4ncdf 653 23 MAVS MAVS NNP cord-001397-nrq4ncdf 653 24 dimer dimer NNP cord-001397-nrq4ncdf 653 25 is be VBZ cord-001397-nrq4ncdf 653 26 a a DT cord-001397-nrq4ncdf 653 27 crucial crucial JJ cord-001397-nrq4ncdf 653 28 signaling signal VBG cord-001397-nrq4ncdf 653 29 component component NN cord-001397-nrq4ncdf 653 30 of of IN cord-001397-nrq4ncdf 653 31 innate innate JJ cord-001397-nrq4ncdf 653 32 immunity immunity NN cord-001397-nrq4ncdf 653 33 and and CC cord-001397-nrq4ncdf 653 34 the the DT cord-001397-nrq4ncdf 653 35 target target NN cord-001397-nrq4ncdf 653 36 of of IN cord-001397-nrq4ncdf 653 37 hepatitis hepatitis NN cord-001397-nrq4ncdf 653 38 C C NNP cord-001397-nrq4ncdf 653 39 virus virus NN cord-001397-nrq4ncdf 653 40 NS3/4A ns3/4a IN cord-001397-nrq4ncdf 653 41 protease protease NN cord-001397-nrq4ncdf 653 42 Variability Variability NNP cord-001397-nrq4ncdf 653 43 in in IN cord-001397-nrq4ncdf 653 44 the the DT cord-001397-nrq4ncdf 653 45 2 2 CD cord-001397-nrq4ncdf 653 46 0 0 CD cord-001397-nrq4ncdf 653 47 -5 -5 CD cord-001397-nrq4ncdf 653 48 0 0 CD cord-001397-nrq4ncdf 653 49 -oligoadenylate -oligoadenylate HYPH cord-001397-nrq4ncdf 653 50 synthetase synthetase NN cord-001397-nrq4ncdf 653 51 gene gene NN cord-001397-nrq4ncdf 653 52 cluster cluster NN cord-001397-nrq4ncdf 653 53 is be VBZ cord-001397-nrq4ncdf 653 54 associated associate VBN cord-001397-nrq4ncdf 653 55 with with IN cord-001397-nrq4ncdf 653 56 human human JJ cord-001397-nrq4ncdf 653 57 predisposition predisposition NN cord-001397-nrq4ncdf 653 58 to to TO cord-001397-nrq4ncdf 653 59 tick tick VB cord-001397-nrq4ncdf 653 60 - - HYPH cord-001397-nrq4ncdf 653 61 borne bear VBN cord-001397-nrq4ncdf 653 62 encephalitis encephalitis JJ cord-001397-nrq4ncdf 653 63 virus virus NN cord-001397-nrq4ncdf 653 64 - - HYPH cord-001397-nrq4ncdf 653 65 induced induce VBN cord-001397-nrq4ncdf 653 66 disease disease NN cord-001397-nrq4ncdf 653 67 Complex complex JJ cord-001397-nrq4ncdf 653 68 formation formation NN cord-001397-nrq4ncdf 653 69 between between IN cord-001397-nrq4ncdf 653 70 the the DT cord-001397-nrq4ncdf 653 71 NS3 ns3 RB cord-001397-nrq4ncdf 653 72 serine serine NN cord-001397-nrq4ncdf 653 73 - - HYPH cord-001397-nrq4ncdf 653 74 type type NN cord-001397-nrq4ncdf 653 75 proteinase proteinase NN cord-001397-nrq4ncdf 653 76 of of IN cord-001397-nrq4ncdf 653 77 the the DT cord-001397-nrq4ncdf 653 78 hepatitis hepatitis NN cord-001397-nrq4ncdf 653 79 C C NNP cord-001397-nrq4ncdf 653 80 virus virus NN cord-001397-nrq4ncdf 653 81 and and CC cord-001397-nrq4ncdf 653 82 NS4A ns4a NN cord-001397-nrq4ncdf 653 83 and and CC cord-001397-nrq4ncdf 653 84 its -PRON- PRP$ cord-001397-nrq4ncdf 653 85 importance importance NN cord-001397-nrq4ncdf 653 86 for for IN cord-001397-nrq4ncdf 653 87 polyprotein polyprotein NNP cord-001397-nrq4ncdf 653 88 maturation maturation NNP cord-001397-nrq4ncdf 653 89 Evaluation Evaluation NNP cord-001397-nrq4ncdf 653 90 for for IN cord-001397-nrq4ncdf 653 91 West West NNP cord-001397-nrq4ncdf 653 92 Nile Nile NNP cord-001397-nrq4ncdf 653 93 virus virus NN cord-001397-nrq4ncdf 653 94 ( ( -LRB- cord-001397-nrq4ncdf 653 95 WNV WNV NNP cord-001397-nrq4ncdf 653 96 ) ) -RRB- cord-001397-nrq4ncdf 653 97 RNA RNA NNP cord-001397-nrq4ncdf 653 98 in in IN cord-001397-nrq4ncdf 653 99 urine urine NN cord-001397-nrq4ncdf 653 100 of of IN cord-001397-nrq4ncdf 653 101 patients patient NNS cord-001397-nrq4ncdf 653 102 within within IN cord-001397-nrq4ncdf 653 103 5 5 CD cord-001397-nrq4ncdf 653 104 months month NNS cord-001397-nrq4ncdf 653 105 of of IN cord-001397-nrq4ncdf 653 106 WNV WNV NNP cord-001397-nrq4ncdf 653 107 infection infection NN cord-001397-nrq4ncdf 653 108 Identification identification NN cord-001397-nrq4ncdf 653 109 of of IN cord-001397-nrq4ncdf 653 110 neutralizing neutralize VBG cord-001397-nrq4ncdf 653 111 epitopes epitope NNS cord-001397-nrq4ncdf 653 112 within within IN cord-001397-nrq4ncdf 653 113 structural structural JJ cord-001397-nrq4ncdf 653 114 domain domain NN cord-001397-nrq4ncdf 653 115 III iii CD cord-001397-nrq4ncdf 653 116 of of IN cord-001397-nrq4ncdf 653 117 the the DT cord-001397-nrq4ncdf 653 118 West West NNP cord-001397-nrq4ncdf 653 119 Nile Nile NNP cord-001397-nrq4ncdf 653 120 virus virus NN cord-001397-nrq4ncdf 653 121 envelope envelope NN cord-001397-nrq4ncdf 653 122 protein protein NN cord-001397-nrq4ncdf 653 123 Molecular molecular JJ cord-001397-nrq4ncdf 653 124 determinants determinant NNS cord-001397-nrq4ncdf 653 125 of of IN cord-001397-nrq4ncdf 653 126 virulence virulence NN cord-001397-nrq4ncdf 653 127 of of IN cord-001397-nrq4ncdf 653 128 West West NNP cord-001397-nrq4ncdf 653 129 Nile Nile NNP cord-001397-nrq4ncdf 653 130 virus virus NN cord-001397-nrq4ncdf 653 131 in in IN cord-001397-nrq4ncdf 653 132 North North NNP cord-001397-nrq4ncdf 653 133 America America NNP cord-001397-nrq4ncdf 653 134 Envelope Envelope NNP cord-001397-nrq4ncdf 653 135 protein protein NN cord-001397-nrq4ncdf 653 136 glycosylation glycosylation NN cord-001397-nrq4ncdf 653 137 status status NN cord-001397-nrq4ncdf 653 138 influences influence VBZ cord-001397-nrq4ncdf 653 139 mouse mouse NN cord-001397-nrq4ncdf 653 140 neuroinvasion neuroinvasion NN cord-001397-nrq4ncdf 653 141 phenotype phenotype NN cord-001397-nrq4ncdf 653 142 of of IN cord-001397-nrq4ncdf 653 143 genetic genetic JJ cord-001397-nrq4ncdf 653 144 lineage lineage NN cord-001397-nrq4ncdf 653 145 1 1 CD cord-001397-nrq4ncdf 653 146 West West NNP cord-001397-nrq4ncdf 653 147 Nile Nile NNP cord-001397-nrq4ncdf 653 148 virus virus NN cord-001397-nrq4ncdf 653 149 strains strain VBZ cord-001397-nrq4ncdf 653 150 Inhibition inhibition NN cord-001397-nrq4ncdf 653 151 of of IN cord-001397-nrq4ncdf 653 152 interferon interferon NN cord-001397-nrq4ncdf 653 153 - - HYPH cord-001397-nrq4ncdf 653 154 stimulated stimulate VBN cord-001397-nrq4ncdf 653 155 JAK JAK NNP cord-001397-nrq4ncdf 653 156 - - HYPH cord-001397-nrq4ncdf 653 157 STAT stat NN cord-001397-nrq4ncdf 653 158 signaling signal VBG cord-001397-nrq4ncdf 653 159 by by IN cord-001397-nrq4ncdf 653 160 a a DT cord-001397-nrq4ncdf 653 161 tick tick NN cord-001397-nrq4ncdf 653 162 - - HYPH cord-001397-nrq4ncdf 653 163 borne bear VBN cord-001397-nrq4ncdf 653 164 flavivirus flavivirus NN cord-001397-nrq4ncdf 653 165 and and CC cord-001397-nrq4ncdf 653 166 identification identification NN cord-001397-nrq4ncdf 653 167 of of IN cord-001397-nrq4ncdf 653 168 NS5 NS5 NNP cord-001397-nrq4ncdf 653 169 as as IN cord-001397-nrq4ncdf 653 170 an an DT cord-001397-nrq4ncdf 653 171 interferon interferon NN cord-001397-nrq4ncdf 653 172 antagonist antagonist NN cord-001397-nrq4ncdf 653 173 A a DT cord-001397-nrq4ncdf 653 174 polypyrimidine polypyrimidine JJ cord-001397-nrq4ncdf 653 175 tract tract NN cord-001397-nrq4ncdf 653 176 facilitates facilitate VBZ cord-001397-nrq4ncdf 653 177 the the DT cord-001397-nrq4ncdf 653 178 expression expression NN cord-001397-nrq4ncdf 653 179 of of IN cord-001397-nrq4ncdf 653 180 Kaposi Kaposi NNP cord-001397-nrq4ncdf 653 181 's 's POS cord-001397-nrq4ncdf 653 182 sarcoma sarcoma NN cord-001397-nrq4ncdf 653 183 - - HYPH cord-001397-nrq4ncdf 653 184 associated associate VBN cord-001397-nrq4ncdf 653 185 herpesvirus herpesvirus NN cord-001397-nrq4ncdf 653 186 vFLIP vFLIP NNP cord-001397-nrq4ncdf 653 187 through through IN cord-001397-nrq4ncdf 653 188 an an DT cord-001397-nrq4ncdf 653 189 internal internal JJ cord-001397-nrq4ncdf 653 190 ribosome ribosome NN cord-001397-nrq4ncdf 653 191 entry entry NN cord-001397-nrq4ncdf 653 192 site site NN cord-001397-nrq4ncdf 653 193 A a DT cord-001397-nrq4ncdf 653 194 novel novel NN cord-001397-nrq4ncdf 653 195 complex complex NN cord-001397-nrq4ncdf 653 196 formed form VBN cord-001397-nrq4ncdf 653 197 between between IN cord-001397-nrq4ncdf 653 198 the the DT cord-001397-nrq4ncdf 653 199 flavivirus flavivirus JJ cord-001397-nrq4ncdf 653 200 E E NNP cord-001397-nrq4ncdf 653 201 and and CC cord-001397-nrq4ncdf 653 202 NS1 ns1 NN cord-001397-nrq4ncdf 653 203 proteins protein NNS cord-001397-nrq4ncdf 653 204 : : : cord-001397-nrq4ncdf 653 205 analysis analysis NN cord-001397-nrq4ncdf 653 206 of of IN cord-001397-nrq4ncdf 653 207 its -PRON- PRP$ cord-001397-nrq4ncdf 653 208 structure structure NN cord-001397-nrq4ncdf 653 209 and and CC cord-001397-nrq4ncdf 653 210 function function VB cord-001397-nrq4ncdf 653 211 Identification identification NN cord-001397-nrq4ncdf 653 212 and and CC cord-001397-nrq4ncdf 653 213 analysis analysis NN cord-001397-nrq4ncdf 653 214 of of IN cord-001397-nrq4ncdf 653 215 truncated truncated JJ cord-001397-nrq4ncdf 653 216 and and CC cord-001397-nrq4ncdf 653 217 elongated elongated JJ cord-001397-nrq4ncdf 653 218 species specie NNS cord-001397-nrq4ncdf 653 219 of of IN cord-001397-nrq4ncdf 653 220 the the DT cord-001397-nrq4ncdf 653 221 flavivirus flavivirus JJ cord-001397-nrq4ncdf 653 222 NS1 NS1 NNP cord-001397-nrq4ncdf 653 223 protein protein NN cord-001397-nrq4ncdf 653 224 OX40 OX40 NNP cord-001397-nrq4ncdf 653 225 facilitates facilitate VBZ cord-001397-nrq4ncdf 653 226 control control NN cord-001397-nrq4ncdf 653 227 of of IN cord-001397-nrq4ncdf 653 228 a a DT cord-001397-nrq4ncdf 653 229 persistent persistent JJ cord-001397-nrq4ncdf 653 230 virus virus NN cord-001397-nrq4ncdf 653 231 infection infection NN cord-001397-nrq4ncdf 653 232 Structure structure NN cord-001397-nrq4ncdf 653 233 and and CC cord-001397-nrq4ncdf 653 234 functionality functionality NN cord-001397-nrq4ncdf 653 235 in in IN cord-001397-nrq4ncdf 653 236 flavivirus flavivirus NNP cord-001397-nrq4ncdf 653 237 NS NS NNP cord-001397-nrq4ncdf 653 238 - - HYPH cord-001397-nrq4ncdf 653 239 proteins protein NNS cord-001397-nrq4ncdf 653 240 : : : cord-001397-nrq4ncdf 653 241 perspectives perspective NNS cord-001397-nrq4ncdf 653 242 for for IN cord-001397-nrq4ncdf 653 243 drug drug NN cord-001397-nrq4ncdf 653 244 design design NN cord-001397-nrq4ncdf 653 245 Dengue dengue NN cord-001397-nrq4ncdf 653 246 neurovirulence neurovirulence NN cord-001397-nrq4ncdf 653 247 in in IN cord-001397-nrq4ncdf 653 248 mice mouse NNS cord-001397-nrq4ncdf 653 249 : : : cord-001397-nrq4ncdf 653 250 identification identification NN cord-001397-nrq4ncdf 653 251 of of IN cord-001397-nrq4ncdf 653 252 molecular molecular JJ cord-001397-nrq4ncdf 653 253 signatures signature NNS cord-001397-nrq4ncdf 653 254 in in IN cord-001397-nrq4ncdf 653 255 the the DT cord-001397-nrq4ncdf 653 256 E e NN cord-001397-nrq4ncdf 653 257 and and CC cord-001397-nrq4ncdf 653 258 NS3 ns3 RB cord-001397-nrq4ncdf 653 259 helicase helicase NN cord-001397-nrq4ncdf 653 260 domains domain NNS cord-001397-nrq4ncdf 653 261 Experimental experimental JJ cord-001397-nrq4ncdf 653 262 infection infection NN cord-001397-nrq4ncdf 653 263 model model NN cord-001397-nrq4ncdf 653 264 for for IN cord-001397-nrq4ncdf 653 265 Sin Sin NNP cord-001397-nrq4ncdf 653 266 Nombre Nombre NNP cord-001397-nrq4ncdf 653 267 hantavirus hantavirus NN cord-001397-nrq4ncdf 653 268 in in IN cord-001397-nrq4ncdf 653 269 the the DT cord-001397-nrq4ncdf 653 270 deer deer NN cord-001397-nrq4ncdf 653 271 mouse mouse NN cord-001397-nrq4ncdf 653 272 ( ( -LRB- cord-001397-nrq4ncdf 653 273 Peromyscus Peromyscus NNP cord-001397-nrq4ncdf 653 274 maniculatus maniculatus NN cord-001397-nrq4ncdf 653 275 ) ) -RRB- cord-001397-nrq4ncdf 654 1 The the DT cord-001397-nrq4ncdf 654 2 effects effect NNS cord-001397-nrq4ncdf 654 3 of of IN cord-001397-nrq4ncdf 654 4 midgut midgut NN cord-001397-nrq4ncdf 654 5 serine serine NN cord-001397-nrq4ncdf 654 6 proteases protease NNS cord-001397-nrq4ncdf 654 7 on on IN cord-001397-nrq4ncdf 654 8 dengue dengue NN cord-001397-nrq4ncdf 654 9 virus virus NN cord-001397-nrq4ncdf 654 10 type type NN cord-001397-nrq4ncdf 654 11 2 2 CD cord-001397-nrq4ncdf 654 12 infectivity infectivity NN cord-001397-nrq4ncdf 654 13 of of IN cord-001397-nrq4ncdf 654 14 Aedes Aedes NNP cord-001397-nrq4ncdf 654 15 aegypti aegypti NN cord-001397-nrq4ncdf 654 16 Stable stable JJ cord-001397-nrq4ncdf 654 17 prevalence prevalence NN cord-001397-nrq4ncdf 654 18 of of IN cord-001397-nrq4ncdf 654 19 Powassan Powassan NNP cord-001397-nrq4ncdf 654 20 virus virus NN cord-001397-nrq4ncdf 654 21 in in IN cord-001397-nrq4ncdf 654 22 Ixodes Ixodes NNP cord-001397-nrq4ncdf 654 23 scapularis scapularis JJ cord-001397-nrq4ncdf 654 24 in in IN cord-001397-nrq4ncdf 654 25 a a DT cord-001397-nrq4ncdf 654 26 Northern Northern NNP cord-001397-nrq4ncdf 654 27 Wisconsin Wisconsin NNP cord-001397-nrq4ncdf 654 28 focus focus NN cord-001397-nrq4ncdf 654 29 Structure Structure NNP cord-001397-nrq4ncdf 654 30 of of IN cord-001397-nrq4ncdf 654 31 a a DT cord-001397-nrq4ncdf 654 32 flavivirus flavivirus JJ cord-001397-nrq4ncdf 654 33 envelope envelope NN cord-001397-nrq4ncdf 654 34 glycoprotein glycoprotein NN cord-001397-nrq4ncdf 654 35 in in IN cord-001397-nrq4ncdf 654 36 its -PRON- PRP$ cord-001397-nrq4ncdf 654 37 low low JJ cord-001397-nrq4ncdf 654 38 - - HYPH cord-001397-nrq4ncdf 654 39 pH ph NN cord-001397-nrq4ncdf 654 40 - - HYPH cord-001397-nrq4ncdf 654 41 induced induce VBN cord-001397-nrq4ncdf 654 42 membrane membrane NN cord-001397-nrq4ncdf 654 43 fusion fusion NN cord-001397-nrq4ncdf 654 44 conformation conformation NN cord-001397-nrq4ncdf 654 45 Characterization characterization NN cord-001397-nrq4ncdf 654 46 of of IN cord-001397-nrq4ncdf 654 47 West West NNP cord-001397-nrq4ncdf 654 48 Nile Nile NNP cord-001397-nrq4ncdf 654 49 virus virus NN cord-001397-nrq4ncdf 654 50 persistent persistent JJ cord-001397-nrq4ncdf 654 51 infections infection NNS cord-001397-nrq4ncdf 654 52 in in IN cord-001397-nrq4ncdf 654 53 genetically genetically RB cord-001397-nrq4ncdf 654 54 resistant resistant JJ cord-001397-nrq4ncdf 654 55 and and CC cord-001397-nrq4ncdf 654 56 susceptible susceptible JJ cord-001397-nrq4ncdf 654 57 mouse mouse NN cord-001397-nrq4ncdf 654 58 cells cell NNS cord-001397-nrq4ncdf 654 59 . . . cord-001397-nrq4ncdf 655 1 I. I. NNP cord-001397-nrq4ncdf 655 2 Generation Generation NNP cord-001397-nrq4ncdf 655 3 of of IN cord-001397-nrq4ncdf 655 4 defective defective JJ cord-001397-nrq4ncdf 655 5 non non JJ cord-001397-nrq4ncdf 655 6 plaquing plaquing NN cord-001397-nrq4ncdf 655 7 virus virus NN cord-001397-nrq4ncdf 655 8 particles particle NNS cord-001397-nrq4ncdf 655 9 Replication replication NN cord-001397-nrq4ncdf 655 10 cycle cycle NN cord-001397-nrq4ncdf 655 11 and and CC cord-001397-nrq4ncdf 655 12 molecular molecular JJ cord-001397-nrq4ncdf 655 13 biology biology NN cord-001397-nrq4ncdf 655 14 of of IN cord-001397-nrq4ncdf 655 15 the the DT cord-001397-nrq4ncdf 655 16 West West NNP cord-001397-nrq4ncdf 655 17 Nile Nile NNP cord-001397-nrq4ncdf 655 18 Virus Virus NNP cord-001397-nrq4ncdf 655 19 Genetic genetic JJ cord-001397-nrq4ncdf 655 20 resistance resistance NN cord-001397-nrq4ncdf 655 21 to to IN cord-001397-nrq4ncdf 655 22 flaviviruses flaviviruses NNP cord-001397-nrq4ncdf 655 23 The the DT cord-001397-nrq4ncdf 655 24 interdomain interdomain JJ cord-001397-nrq4ncdf 655 25 region region NN cord-001397-nrq4ncdf 655 26 of of IN cord-001397-nrq4ncdf 655 27 dengue dengue NN cord-001397-nrq4ncdf 655 28 NS5 ns5 JJ cord-001397-nrq4ncdf 655 29 protein protein NN cord-001397-nrq4ncdf 655 30 that that WDT cord-001397-nrq4ncdf 655 31 binds bind VBZ cord-001397-nrq4ncdf 655 32 to to IN cord-001397-nrq4ncdf 655 33 the the DT cord-001397-nrq4ncdf 655 34 viral viral JJ cord-001397-nrq4ncdf 655 35 helicase helicase NN cord-001397-nrq4ncdf 656 1 NS3 ns3 RB cord-001397-nrq4ncdf 656 2 contains contain VBZ cord-001397-nrq4ncdf 656 3 independently independently RB cord-001397-nrq4ncdf 656 4 functional functional JJ cord-001397-nrq4ncdf 656 5 importin importin NN cord-001397-nrq4ncdf 657 1 beta beta NN cord-001397-nrq4ncdf 657 2 1 1 CD cord-001397-nrq4ncdf 657 3 and and CC cord-001397-nrq4ncdf 657 4 importin importin NNP cord-001397-nrq4ncdf 658 1 alpha alpha NN cord-001397-nrq4ncdf 658 2 / / SYM cord-001397-nrq4ncdf 658 3 beta beta NN cord-001397-nrq4ncdf 658 4 - - HYPH cord-001397-nrq4ncdf 658 5 recognized recognize VBN cord-001397-nrq4ncdf 658 6 nuclear nuclear JJ cord-001397-nrq4ncdf 658 7 localization localization NN cord-001397-nrq4ncdf 658 8 signals signal NNS cord-001397-nrq4ncdf 658 9 Tick tick VB cord-001397-nrq4ncdf 658 10 - - HYPH cord-001397-nrq4ncdf 658 11 borne bear VBN cord-001397-nrq4ncdf 658 12 encephalitis encephalitis JJ cord-001397-nrq4ncdf 658 13 virus virus NN cord-001397-nrq4ncdf 658 14 NS1 NS1 VBZ cord-001397-nrq4ncdf 658 15 glycoprotein glycoprotein NN cord-001397-nrq4ncdf 658 16 during during IN cord-001397-nrq4ncdf 658 17 acute acute JJ cord-001397-nrq4ncdf 658 18 and and CC cord-001397-nrq4ncdf 658 19 persistent persistent JJ cord-001397-nrq4ncdf 658 20 infection infection NN cord-001397-nrq4ncdf 658 21 of of IN cord-001397-nrq4ncdf 658 22 cells cell NNS cord-001397-nrq4ncdf 658 23 Virus virus NN cord-001397-nrq4ncdf 658 24 and and CC cord-001397-nrq4ncdf 658 25 antibody antibody NN cord-001397-nrq4ncdf 658 26 dynamics dynamic NNS cord-001397-nrq4ncdf 658 27 in in IN cord-001397-nrq4ncdf 658 28 acute acute JJ cord-001397-nrq4ncdf 658 29 West West NNP cord-001397-nrq4ncdf 658 30 Nile Nile NNP cord-001397-nrq4ncdf 658 31 virus virus NN cord-001397-nrq4ncdf 658 32 infection infection NN cord-001397-nrq4ncdf 658 33 Effects effect NNS cord-001397-nrq4ncdf 658 34 of of IN cord-001397-nrq4ncdf 658 35 deer deer NN cord-001397-nrq4ncdf 658 36 density density NN cord-001397-nrq4ncdf 658 37 on on IN cord-001397-nrq4ncdf 658 38 tick tick NN cord-001397-nrq4ncdf 658 39 infestation infestation NN cord-001397-nrq4ncdf 658 40 of of IN cord-001397-nrq4ncdf 658 41 rodents rodent NNS cord-001397-nrq4ncdf 658 42 and and CC cord-001397-nrq4ncdf 658 43 the the DT cord-001397-nrq4ncdf 658 44 hazard hazard NN cord-001397-nrq4ncdf 658 45 of of IN cord-001397-nrq4ncdf 658 46 tick tick NN cord-001397-nrq4ncdf 658 47 - - HYPH cord-001397-nrq4ncdf 658 48 borne bear VBN cord-001397-nrq4ncdf 658 49 encephalitis encephalitis RB cord-001397-nrq4ncdf 658 50 . . . cord-001397-nrq4ncdf 659 1 I -PRON- PRP cord-001397-nrq4ncdf 659 2 : : : cord-001397-nrq4ncdf 660 1 Empirical empirical JJ cord-001397-nrq4ncdf 660 2 assessment assessment NN cord-001397-nrq4ncdf 660 3 Tick tick NN cord-001397-nrq4ncdf 660 4 - - : cord-001397-nrq4ncdf 660 5 borne bear VBN cord-001397-nrq4ncdf 660 6 encephalitis encephalitis RB cord-001397-nrq4ncdf 660 7 transmitted transmit VBN cord-001397-nrq4ncdf 660 8 by by IN cord-001397-nrq4ncdf 660 9 unpasteurised unpasteurised JJ cord-001397-nrq4ncdf 660 10 cow cow NN cord-001397-nrq4ncdf 660 11 milk milk NN cord-001397-nrq4ncdf 660 12 in in IN cord-001397-nrq4ncdf 660 13 western western JJ cord-001397-nrq4ncdf 660 14 Hungary Hungary NNP cord-001397-nrq4ncdf 660 15 Prevalence Prevalence NNP cord-001397-nrq4ncdf 660 16 and and CC cord-001397-nrq4ncdf 660 17 genetic genetic JJ cord-001397-nrq4ncdf 660 18 variability variability NN cord-001397-nrq4ncdf 660 19 of of IN cord-001397-nrq4ncdf 660 20 tick tick NN cord-001397-nrq4ncdf 660 21 - - HYPH cord-001397-nrq4ncdf 660 22 borne bear VBN cord-001397-nrq4ncdf 660 23 encephalitis encephalitis JJ cord-001397-nrq4ncdf 660 24 virus virus NN cord-001397-nrq4ncdf 660 25 in in IN cord-001397-nrq4ncdf 660 26 host host NN cord-001397-nrq4ncdf 660 27 - - HYPH cord-001397-nrq4ncdf 660 28 seeking seek VBG cord-001397-nrq4ncdf 660 29 Ixodes Ixodes NNP cord-001397-nrq4ncdf 660 30 ricinus ricinus NN cord-001397-nrq4ncdf 660 31 in in IN cord-001397-nrq4ncdf 660 32 northern northern JJ cord-001397-nrq4ncdf 660 33 Italy Italy NNP cord-001397-nrq4ncdf 660 34 Long long JJ cord-001397-nrq4ncdf 660 35 - - HYPH cord-001397-nrq4ncdf 660 36 term term NN cord-001397-nrq4ncdf 660 37 clinical clinical JJ cord-001397-nrq4ncdf 660 38 and and CC cord-001397-nrq4ncdf 660 39 neuropsychological neuropsychological JJ cord-001397-nrq4ncdf 660 40 outcomes outcome NNS cord-001397-nrq4ncdf 660 41 of of IN cord-001397-nrq4ncdf 660 42 West West NNP cord-001397-nrq4ncdf 660 43 Nile Nile NNP cord-001397-nrq4ncdf 660 44 virus virus NN cord-001397-nrq4ncdf 660 45 Infection infection NN cord-001397-nrq4ncdf 660 46 Defective defective JJ cord-001397-nrq4ncdf 660 47 interfering interfere VBG cord-001397-nrq4ncdf 660 48 virus virus NN cord-001397-nrq4ncdf 660 49 particles particle NNS cord-001397-nrq4ncdf 660 50 modulate modulate VBP cord-001397-nrq4ncdf 660 51 virulence virulence NN cord-001397-nrq4ncdf 660 52 West West NNP cord-001397-nrq4ncdf 660 53 Nile Nile NNP cord-001397-nrq4ncdf 660 54 virus virus NN cord-001397-nrq4ncdf 660 55 transmission transmission NN cord-001397-nrq4ncdf 660 56 via via IN cord-001397-nrq4ncdf 660 57 organ organ NN cord-001397-nrq4ncdf 660 58 transplantation transplantation NN cord-001397-nrq4ncdf 660 59 and and CC cord-001397-nrq4ncdf 660 60 blood blood NN cord-001397-nrq4ncdf 660 61 transfusion transfusion NN cord-001397-nrq4ncdf 661 1 -Louisiana -Louisiana JJS cord-001397-nrq4ncdf 661 2 Nucleotide nucleotide JJ cord-001397-nrq4ncdf 661 3 changes change NNS cord-001397-nrq4ncdf 661 4 responsible responsible JJ cord-001397-nrq4ncdf 661 5 for for IN cord-001397-nrq4ncdf 661 6 loss loss NN cord-001397-nrq4ncdf 661 7 of of IN cord-001397-nrq4ncdf 661 8 neuroinvasiveness neuroinvasiveness NN cord-001397-nrq4ncdf 661 9 in in IN cord-001397-nrq4ncdf 661 10 Japanese japanese JJ cord-001397-nrq4ncdf 661 11 encephalitis encephalitis RB cord-001397-nrq4ncdf 661 12 virus virus NN cord-001397-nrq4ncdf 661 13 neutralization neutralization NN cord-001397-nrq4ncdf 661 14 - - HYPH cord-001397-nrq4ncdf 661 15 resistant resistant JJ cord-001397-nrq4ncdf 661 16 mutants mutant NNS cord-001397-nrq4ncdf 661 17 Flavivirus Flavivirus NNP cord-001397-nrq4ncdf 661 18 genome genome NN cord-001397-nrq4ncdf 661 19 organization organization NN cord-001397-nrq4ncdf 661 20 , , , cord-001397-nrq4ncdf 661 21 expression expression NN cord-001397-nrq4ncdf 661 22 , , , cord-001397-nrq4ncdf 661 23 and and CC cord-001397-nrq4ncdf 661 24 replication replication NN cord-001397-nrq4ncdf 661 25 Processing processing NN cord-001397-nrq4ncdf 661 26 of of IN cord-001397-nrq4ncdf 661 27 the the DT cord-001397-nrq4ncdf 661 28 yellow yellow JJ cord-001397-nrq4ncdf 661 29 fever fever NNP cord-001397-nrq4ncdf 661 30 virus virus NN cord-001397-nrq4ncdf 661 31 nonstructural nonstructural NNP cord-001397-nrq4ncdf 661 32 polyprotein polyprotein NNP cord-001397-nrq4ncdf 661 33 : : : cord-001397-nrq4ncdf 661 34 a a DT cord-001397-nrq4ncdf 661 35 catalytically catalytically RB cord-001397-nrq4ncdf 661 36 active active JJ cord-001397-nrq4ncdf 661 37 NS3 ns3 RB cord-001397-nrq4ncdf 661 38 proteinase proteinase NN cord-001397-nrq4ncdf 661 39 domain domain NN cord-001397-nrq4ncdf 661 40 and and CC cord-001397-nrq4ncdf 661 41 NS2B NS2B NNP cord-001397-nrq4ncdf 661 42 are be VBP cord-001397-nrq4ncdf 661 43 required require VBN cord-001397-nrq4ncdf 661 44 for for IN cord-001397-nrq4ncdf 661 45 cleavages cleavage NNS cord-001397-nrq4ncdf 661 46 at at IN cord-001397-nrq4ncdf 661 47 dibasic dibasic NN cord-001397-nrq4ncdf 661 48 sites site NNS cord-001397-nrq4ncdf 661 49 West West NNP cord-001397-nrq4ncdf 661 50 Nile Nile NNP cord-001397-nrq4ncdf 661 51 virus virus NN cord-001397-nrq4ncdf 661 52 envelope envelope NN cord-001397-nrq4ncdf 661 53 proteins protein NNS cord-001397-nrq4ncdf 661 54 : : : cord-001397-nrq4ncdf 661 55 nucleotide nucleotide JJ cord-001397-nrq4ncdf 661 56 sequence sequence NN cord-001397-nrq4ncdf 661 57 analysis analysis NN cord-001397-nrq4ncdf 661 58 of of IN cord-001397-nrq4ncdf 661 59 strains strain NNS cord-001397-nrq4ncdf 661 60 differing differ VBG cord-001397-nrq4ncdf 661 61 in in IN cord-001397-nrq4ncdf 661 62 mouse mouse NN cord-001397-nrq4ncdf 661 63 neuroinvasiveness neuroinvasiveness NN cord-001397-nrq4ncdf 662 1 The the DT cord-001397-nrq4ncdf 662 2 polypyrimidine polypyrimidine JJ cord-001397-nrq4ncdf 662 3 tract tract NN cord-001397-nrq4ncdf 662 4 - - HYPH cord-001397-nrq4ncdf 662 5 binding bind VBG cord-001397-nrq4ncdf 662 6 protein protein NN cord-001397-nrq4ncdf 662 7 ( ( -LRB- cord-001397-nrq4ncdf 662 8 PTB PTB NNP cord-001397-nrq4ncdf 662 9 ) ) -RRB- cord-001397-nrq4ncdf 662 10 is be VBZ cord-001397-nrq4ncdf 662 11 required require VBN cord-001397-nrq4ncdf 662 12 for for IN cord-001397-nrq4ncdf 662 13 efficient efficient JJ cord-001397-nrq4ncdf 662 14 replication replication NN cord-001397-nrq4ncdf 662 15 of of IN cord-001397-nrq4ncdf 662 16 hepatitis hepatitis NN cord-001397-nrq4ncdf 662 17 C C NNP cord-001397-nrq4ncdf 662 18 virus virus NN cord-001397-nrq4ncdf 662 19 ( ( -LRB- cord-001397-nrq4ncdf 662 20 HCV HCV NNP cord-001397-nrq4ncdf 662 21 ) ) -RRB- cord-001397-nrq4ncdf 662 22 RNA RNA NNP cord-001397-nrq4ncdf 662 23 Membrane Membrane NNP cord-001397-nrq4ncdf 662 24 permeabilization permeabilization NN cord-001397-nrq4ncdf 662 25 by by IN cord-001397-nrq4ncdf 662 26 small small JJ cord-001397-nrq4ncdf 662 27 hydrophobic hydrophobic JJ cord-001397-nrq4ncdf 662 28 nonstructural nonstructural JJ cord-001397-nrq4ncdf 662 29 proteins protein NNS cord-001397-nrq4ncdf 662 30 of of IN cord-001397-nrq4ncdf 662 31 Japanese japanese JJ cord-001397-nrq4ncdf 662 32 encephalitis encephalitis RB cord-001397-nrq4ncdf 662 33 virus virus NN cord-001397-nrq4ncdf 662 34 Japanese japanese JJ cord-001397-nrq4ncdf 662 35 encephalitis encephalitis RB cord-001397-nrq4ncdf 662 36 virus virus NN cord-001397-nrq4ncdf 662 37 non non JJ cord-001397-nrq4ncdf 662 38 - - JJ cord-001397-nrq4ncdf 662 39 coding coding JJ cord-001397-nrq4ncdf 662 40 RNA RNA NNP cord-001397-nrq4ncdf 662 41 inhibits inhibit VBZ cord-001397-nrq4ncdf 662 42 activation activation NN cord-001397-nrq4ncdf 662 43 of of IN cord-001397-nrq4ncdf 662 44 interferon interferon NN cord-001397-nrq4ncdf 662 45 by by IN cord-001397-nrq4ncdf 662 46 blocking block VBG cord-001397-nrq4ncdf 662 47 nuclear nuclear JJ cord-001397-nrq4ncdf 662 48 translocation translocation NN cord-001397-nrq4ncdf 662 49 of of IN cord-001397-nrq4ncdf 662 50 interferon interferon NN cord-001397-nrq4ncdf 662 51 regulatory regulatory JJ cord-001397-nrq4ncdf 662 52 factor factor NN cord-001397-nrq4ncdf 662 53 3 3 CD cord-001397-nrq4ncdf 662 54 Rodent Rodent NNP cord-001397-nrq4ncdf 662 55 models model NNS cord-001397-nrq4ncdf 662 56 for for IN cord-001397-nrq4ncdf 662 57 the the DT cord-001397-nrq4ncdf 662 58 study study NN cord-001397-nrq4ncdf 662 59 of of IN cord-001397-nrq4ncdf 662 60 therapy therapy NN cord-001397-nrq4ncdf 662 61 against against IN cord-001397-nrq4ncdf 662 62 flavivirus flavivirus NNP cord-001397-nrq4ncdf 662 63 infections infection NNS cord-001397-nrq4ncdf 663 1 Alkhurma Alkhurma NNP cord-001397-nrq4ncdf 663 2 hemorrhagic hemorrhagic JJ cord-001397-nrq4ncdf 663 3 fever fever NN cord-001397-nrq4ncdf 663 4 virus virus NN cord-001397-nrq4ncdf 663 5 in in IN cord-001397-nrq4ncdf 663 6 Ornithodoros Ornithodoros NNP cord-001397-nrq4ncdf 663 7 savignyi savignyi NNP cord-001397-nrq4ncdf 663 8 ticks tick NNS cord-001397-nrq4ncdf 664 1 Persistence persistence NN cord-001397-nrq4ncdf 664 2 of of IN cord-001397-nrq4ncdf 664 3 Japanese japanese JJ cord-001397-nrq4ncdf 664 4 encephalitis encephalitis NN cord-001397-nrq4ncdf 664 5 virus virus NN cord-001397-nrq4ncdf 664 6 is be VBZ cord-001397-nrq4ncdf 664 7 associated associate VBN cord-001397-nrq4ncdf 664 8 with with IN cord-001397-nrq4ncdf 664 9 abnormal abnormal JJ cord-001397-nrq4ncdf 664 10 expression expression NN cord-001397-nrq4ncdf 664 11 of of IN cord-001397-nrq4ncdf 664 12 the the DT cord-001397-nrq4ncdf 664 13 nonstructural nonstructural JJ cord-001397-nrq4ncdf 664 14 protein protein NN cord-001397-nrq4ncdf 664 15 NS1 NS1 NNS cord-001397-nrq4ncdf 664 16 in in IN cord-001397-nrq4ncdf 664 17 host host NN cord-001397-nrq4ncdf 664 18 cells cell NNS cord-001397-nrq4ncdf 664 19 RNA rna NN cord-001397-nrq4ncdf 664 20 - - HYPH cord-001397-nrq4ncdf 664 21 protein protein NN cord-001397-nrq4ncdf 664 22 interactions interaction NNS cord-001397-nrq4ncdf 664 23 : : : cord-001397-nrq4ncdf 664 24 involvement involvement NN cord-001397-nrq4ncdf 664 25 of of IN cord-001397-nrq4ncdf 664 26 NS3 ns3 RB cord-001397-nrq4ncdf 664 27 , , , cord-001397-nrq4ncdf 664 28 NS5 ns5 JJ cord-001397-nrq4ncdf 664 29 , , , cord-001397-nrq4ncdf 664 30 and and CC cord-001397-nrq4ncdf 664 31 3 3 CD cord-001397-nrq4ncdf 664 32 0 0 CD cord-001397-nrq4ncdf 664 33 noncoding noncoding JJ cord-001397-nrq4ncdf 664 34 regions region NNS cord-001397-nrq4ncdf 664 35 of of IN cord-001397-nrq4ncdf 664 36 Japanese japanese JJ cord-001397-nrq4ncdf 664 37 encephalitis encephalitis RB cord-001397-nrq4ncdf 664 38 virus virus NN cord-001397-nrq4ncdf 664 39 genomic genomic JJ cord-001397-nrq4ncdf 664 40 RNA RNA NNP cord-001397-nrq4ncdf 664 41 Susceptibility Susceptibility NNP cord-001397-nrq4ncdf 664 42 of of IN cord-001397-nrq4ncdf 664 43 greater great JJR cord-001397-nrq4ncdf 664 44 sage sage NN cord-001397-nrq4ncdf 664 45 - - HYPH cord-001397-nrq4ncdf 664 46 grouse grouse NN cord-001397-nrq4ncdf 664 47 to to IN cord-001397-nrq4ncdf 664 48 experimental experimental JJ cord-001397-nrq4ncdf 664 49 infection infection NN cord-001397-nrq4ncdf 664 50 with with IN cord-001397-nrq4ncdf 664 51 West West NNP cord-001397-nrq4ncdf 664 52 Nile Nile NNP cord-001397-nrq4ncdf 664 53 virus virus NN cord-001397-nrq4ncdf 664 54 West West NNP cord-001397-nrq4ncdf 664 55 Nile Nile NNP cord-001397-nrq4ncdf 664 56 virus virus NN cord-001397-nrq4ncdf 664 57 : : : cord-001397-nrq4ncdf 665 1 biology biology NN cord-001397-nrq4ncdf 665 2 , , , cord-001397-nrq4ncdf 665 3 transmission transmission NN cord-001397-nrq4ncdf 665 4 , , , cord-001397-nrq4ncdf 665 5 and and CC cord-001397-nrq4ncdf 665 6 human human JJ cord-001397-nrq4ncdf 665 7 infection infection NN cord-001397-nrq4ncdf 665 8 Sequences Sequences NNPS cord-001397-nrq4ncdf 665 9 of of IN cord-001397-nrq4ncdf 665 10 flavivirus flavivirus JJ cord-001397-nrq4ncdf 665 11 - - HYPH cord-001397-nrq4ncdf 665 12 related relate VBN cord-001397-nrq4ncdf 665 13 RNA RNA NNP cord-001397-nrq4ncdf 665 14 viruses virus NNS cord-001397-nrq4ncdf 665 15 persist persist VBP cord-001397-nrq4ncdf 665 16 in in IN cord-001397-nrq4ncdf 665 17 DNA dna NN cord-001397-nrq4ncdf 665 18 form form NN cord-001397-nrq4ncdf 665 19 integrated integrate VBN cord-001397-nrq4ncdf 665 20 in in IN cord-001397-nrq4ncdf 665 21 the the DT cord-001397-nrq4ncdf 665 22 genome genome NN cord-001397-nrq4ncdf 665 23 of of IN cord-001397-nrq4ncdf 665 24 Aedes Aedes NNP cord-001397-nrq4ncdf 665 25 spp spp NNS cord-001397-nrq4ncdf 665 26 . . . cord-001397-nrq4ncdf 666 1 mosquitoes mosquito NNS cord-001397-nrq4ncdf 667 1 West West NNP cord-001397-nrq4ncdf 667 2 Nile Nile NNP cord-001397-nrq4ncdf 667 3 virus virus NN cord-001397-nrq4ncdf 667 4 prevalence prevalence NN cord-001397-nrq4ncdf 667 5 across across IN cord-001397-nrq4ncdf 667 6 landscapes landscape NNS cord-001397-nrq4ncdf 667 7 is be VBZ cord-001397-nrq4ncdf 667 8 mediated mediate VBN cord-001397-nrq4ncdf 667 9 by by IN cord-001397-nrq4ncdf 667 10 local local JJ cord-001397-nrq4ncdf 667 11 effects effect NNS cord-001397-nrq4ncdf 667 12 of of IN cord-001397-nrq4ncdf 667 13 agriculture agriculture NN cord-001397-nrq4ncdf 667 14 on on IN cord-001397-nrq4ncdf 667 15 vector vector NN cord-001397-nrq4ncdf 667 16 and and CC cord-001397-nrq4ncdf 667 17 host host NN cord-001397-nrq4ncdf 667 18 communities community NNS cord-001397-nrq4ncdf 667 19 Purification purification NN cord-001397-nrq4ncdf 667 20 and and CC cord-001397-nrq4ncdf 667 21 crystallization crystallization NN cord-001397-nrq4ncdf 667 22 of of IN cord-001397-nrq4ncdf 667 23 dengue dengue NN cord-001397-nrq4ncdf 667 24 and and CC cord-001397-nrq4ncdf 667 25 West West NNP cord-001397-nrq4ncdf 667 26 Nile Nile NNP cord-001397-nrq4ncdf 667 27 virus virus NN cord-001397-nrq4ncdf 667 28 NS2B NS2B NNP cord-001397-nrq4ncdf 667 29 - - : cord-001397-nrq4ncdf 667 30 NS3 ns3 RB cord-001397-nrq4ncdf 667 31 complexes complex NNS cord-001397-nrq4ncdf 667 32 Interaction Interaction NNP cord-001397-nrq4ncdf 667 33 between between IN cord-001397-nrq4ncdf 667 34 the the DT cord-001397-nrq4ncdf 667 35 cellular cellular JJ cord-001397-nrq4ncdf 667 36 protein protein NN cord-001397-nrq4ncdf 667 37 eEF1A eef1a NN cord-001397-nrq4ncdf 667 38 and and CC cord-001397-nrq4ncdf 667 39 the the DT cord-001397-nrq4ncdf 667 40 3 3 CD cord-001397-nrq4ncdf 667 41 0 0 CD cord-001397-nrq4ncdf 667 42 -terminal -terminal JJ cord-001397-nrq4ncdf 667 43 stem stem NN cord-001397-nrq4ncdf 667 44 - - HYPH cord-001397-nrq4ncdf 667 45 loop loop NN cord-001397-nrq4ncdf 667 46 of of IN cord-001397-nrq4ncdf 667 47 West West NNP cord-001397-nrq4ncdf 667 48 Nile Nile NNP cord-001397-nrq4ncdf 667 49 virus virus NN cord-001397-nrq4ncdf 667 50 genomic genomic JJ cord-001397-nrq4ncdf 667 51 RNA RNA NNP cord-001397-nrq4ncdf 667 52 facilitates facilitate VBZ cord-001397-nrq4ncdf 667 53 viral viral JJ cord-001397-nrq4ncdf 667 54 minus minus JJ cord-001397-nrq4ncdf 667 55 - - HYPH cord-001397-nrq4ncdf 667 56 strand strand NN cord-001397-nrq4ncdf 667 57 RNA RNA NNP cord-001397-nrq4ncdf 667 58 synthesis synthesis NN cord-001397-nrq4ncdf 667 59 Powassan Powassan NNP cord-001397-nrq4ncdf 667 60 virus virus NN cord-001397-nrq4ncdf 667 61 in in IN cord-001397-nrq4ncdf 667 62 mammals mammal NNS cord-001397-nrq4ncdf 668 1 In in IN cord-001397-nrq4ncdf 668 2 vitro vitro FW cord-001397-nrq4ncdf 668 3 homotypic homotypic NNP cord-001397-nrq4ncdf 668 4 and and CC cord-001397-nrq4ncdf 668 5 heterotypic heterotypic NNP cord-001397-nrq4ncdf 668 6 interference interference NN cord-001397-nrq4ncdf 668 7 by by IN cord-001397-nrq4ncdf 668 8 defective defective JJ cord-001397-nrq4ncdf 668 9 interfering interfere VBG cord-001397-nrq4ncdf 668 10 particles particle NNS cord-001397-nrq4ncdf 668 11 of of IN cord-001397-nrq4ncdf 668 12 West West NNP cord-001397-nrq4ncdf 668 13 Nile Nile NNP cord-001397-nrq4ncdf 668 14 virus virus NN cord-001397-nrq4ncdf 668 15 Evasion evasion NN cord-001397-nrq4ncdf 668 16 of of IN cord-001397-nrq4ncdf 668 17 innate innate JJ cord-001397-nrq4ncdf 668 18 and and CC cord-001397-nrq4ncdf 668 19 adaptive adaptive JJ cord-001397-nrq4ncdf 668 20 immunity immunity NN cord-001397-nrq4ncdf 668 21 by by IN cord-001397-nrq4ncdf 668 22 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 668 23 Nucleotide Nucleotide NNP cord-001397-nrq4ncdf 668 24 and and CC cord-001397-nrq4ncdf 668 25 amino amino NN cord-001397-nrq4ncdf 668 26 acid acid NN cord-001397-nrq4ncdf 668 27 changes change NNS cord-001397-nrq4ncdf 668 28 in in IN cord-001397-nrq4ncdf 668 29 West West NNP cord-001397-nrq4ncdf 668 30 Nile Nile NNP cord-001397-nrq4ncdf 668 31 virus virus NN cord-001397-nrq4ncdf 668 32 strains strain VBZ cord-001397-nrq4ncdf 668 33 exhibiting exhibit VBG cord-001397-nrq4ncdf 668 34 renal renal JJ cord-001397-nrq4ncdf 668 35 tropism tropism NN cord-001397-nrq4ncdf 668 36 in in IN cord-001397-nrq4ncdf 668 37 hamsters hamster NNS cord-001397-nrq4ncdf 668 38 Epidemiology epidemiology NN cord-001397-nrq4ncdf 668 39 and and CC cord-001397-nrq4ncdf 668 40 distribution distribution NN cord-001397-nrq4ncdf 668 41 of of IN cord-001397-nrq4ncdf 668 42 tick tick NN cord-001397-nrq4ncdf 668 43 - - HYPH cord-001397-nrq4ncdf 668 44 borne bear VBN cord-001397-nrq4ncdf 668 45 encephalitis encephalitis JJ cord-001397-nrq4ncdf 668 46 West West NNP cord-001397-nrq4ncdf 668 47 Nile Nile NNP cord-001397-nrq4ncdf 668 48 virus virus NN cord-001397-nrq4ncdf 668 49 antibody antibody NN cord-001397-nrq4ncdf 668 50 prevalence prevalence NN cord-001397-nrq4ncdf 668 51 in in IN cord-001397-nrq4ncdf 668 52 wild wild JJ cord-001397-nrq4ncdf 668 53 mammals mammal NNS cord-001397-nrq4ncdf 668 54 Role role NN cord-001397-nrq4ncdf 668 55 of of IN cord-001397-nrq4ncdf 668 56 La La NNP cord-001397-nrq4ncdf 668 57 autoantigen autoantigen NNP cord-001397-nrq4ncdf 668 58 and and CC cord-001397-nrq4ncdf 668 59 polypyrimidine polypyrimidine JJ cord-001397-nrq4ncdf 668 60 tract tract NN cord-001397-nrq4ncdf 668 61 - - HYPH cord-001397-nrq4ncdf 668 62 binding bind VBG cord-001397-nrq4ncdf 668 63 protein protein NN cord-001397-nrq4ncdf 668 64 in in IN cord-001397-nrq4ncdf 668 65 HCV HCV NNP cord-001397-nrq4ncdf 668 66 replication replication NN cord-001397-nrq4ncdf 668 67 Determinants determinant NNS cord-001397-nrq4ncdf 668 68 in in IN cord-001397-nrq4ncdf 668 69 the the DT cord-001397-nrq4ncdf 668 70 envelope envelope NN cord-001397-nrq4ncdf 668 71 E e NN cord-001397-nrq4ncdf 668 72 protein protein NN cord-001397-nrq4ncdf 668 73 and and CC cord-001397-nrq4ncdf 668 74 viral viral JJ cord-001397-nrq4ncdf 668 75 RNA RNA NNP cord-001397-nrq4ncdf 669 1 helicase helicase NNP cord-001397-nrq4ncdf 669 2 NS3 ns3 RB cord-001397-nrq4ncdf 670 1 that that DT cord-001397-nrq4ncdf 670 2 influence influence VBP cord-001397-nrq4ncdf 670 3 the the DT cord-001397-nrq4ncdf 670 4 induction induction NN cord-001397-nrq4ncdf 670 5 of of IN cord-001397-nrq4ncdf 670 6 apoptosis apoptosis NN cord-001397-nrq4ncdf 670 7 in in IN cord-001397-nrq4ncdf 670 8 response response NN cord-001397-nrq4ncdf 670 9 to to IN cord-001397-nrq4ncdf 670 10 infection infection NN cord-001397-nrq4ncdf 670 11 with with IN cord-001397-nrq4ncdf 670 12 dengue dengue NN cord-001397-nrq4ncdf 670 13 type type NN cord-001397-nrq4ncdf 670 14 1 1 CD cord-001397-nrq4ncdf 670 15 virus virus NN cord-001397-nrq4ncdf 670 16 Isolation isolation NN cord-001397-nrq4ncdf 670 17 of of IN cord-001397-nrq4ncdf 670 18 deer deer NN cord-001397-nrq4ncdf 670 19 tick tick NN cord-001397-nrq4ncdf 670 20 virus virus NN cord-001397-nrq4ncdf 670 21 ( ( -LRB- cord-001397-nrq4ncdf 670 22 Powassan Powassan NNP cord-001397-nrq4ncdf 670 23 virus virus NN cord-001397-nrq4ncdf 670 24 , , , cord-001397-nrq4ncdf 670 25 lineage lineage NN cord-001397-nrq4ncdf 670 26 II II NNP cord-001397-nrq4ncdf 670 27 ) ) -RRB- cord-001397-nrq4ncdf 670 28 from from IN cord-001397-nrq4ncdf 670 29 Ixodes Ixodes NNP cord-001397-nrq4ncdf 670 30 scapularis scapularis NN cord-001397-nrq4ncdf 670 31 and and CC cord-001397-nrq4ncdf 670 32 detection detection NN cord-001397-nrq4ncdf 670 33 of of IN cord-001397-nrq4ncdf 670 34 antibody antibody NN cord-001397-nrq4ncdf 670 35 in in IN cord-001397-nrq4ncdf 670 36 vertebrate vertebrate JJ cord-001397-nrq4ncdf 670 37 hosts host NNS cord-001397-nrq4ncdf 670 38 sampled sample VBN cord-001397-nrq4ncdf 670 39 in in IN cord-001397-nrq4ncdf 670 40 the the DT cord-001397-nrq4ncdf 670 41 Hudson Hudson NNP cord-001397-nrq4ncdf 670 42 Valley Valley NNP cord-001397-nrq4ncdf 670 43 Immunological Immunological NNP cord-001397-nrq4ncdf 670 44 mechanisms mechanism NNS cord-001397-nrq4ncdf 670 45 mediating mediate VBG cord-001397-nrq4ncdf 670 46 hantavirus hantavirus NN cord-001397-nrq4ncdf 670 47 persistence persistence NN cord-001397-nrq4ncdf 670 48 in in IN cord-001397-nrq4ncdf 670 49 rodent rodent NN cord-001397-nrq4ncdf 670 50 reservoirs reservoir NNS cord-001397-nrq4ncdf 670 51 Update update VBP cord-001397-nrq4ncdf 670 52 on on IN cord-001397-nrq4ncdf 670 53 Powassan Powassan NNP cord-001397-nrq4ncdf 670 54 virus virus NN cord-001397-nrq4ncdf 670 55 : : : cord-001397-nrq4ncdf 670 56 emergence emergence NN cord-001397-nrq4ncdf 670 57 of of IN cord-001397-nrq4ncdf 670 58 a a DT cord-001397-nrq4ncdf 670 59 North north JJ cord-001397-nrq4ncdf 670 60 American american JJ cord-001397-nrq4ncdf 670 61 tick tick NN cord-001397-nrq4ncdf 670 62 - - HYPH cord-001397-nrq4ncdf 670 63 borne bear VBN cord-001397-nrq4ncdf 670 64 flavivirus flavivirus JJ cord-001397-nrq4ncdf 670 65 Structural structural JJ cord-001397-nrq4ncdf 670 66 basis basis NN cord-001397-nrq4ncdf 670 67 of of IN cord-001397-nrq4ncdf 670 68 flavivirus flavivirus NNP cord-001397-nrq4ncdf 670 69 NS1 NS1 NNP cord-001397-nrq4ncdf 670 70 assembly assembly NN cord-001397-nrq4ncdf 670 71 and and CC cord-001397-nrq4ncdf 670 72 antibody antibody NN cord-001397-nrq4ncdf 670 73 recognition recognition NN cord-001397-nrq4ncdf 671 1 An an DT cord-001397-nrq4ncdf 671 2 RNA RNA NNP cord-001397-nrq4ncdf 671 3 cap cap NN cord-001397-nrq4ncdf 671 4 ( ( -LRB- cord-001397-nrq4ncdf 671 5 nucleoside-2 nucleoside-2 NNP cord-001397-nrq4ncdf 671 6 0 0 CD cord-001397-nrq4ncdf 671 7 -O-)-methyltransferase -o-)-methyltransferase NN cord-001397-nrq4ncdf 671 8 in in IN cord-001397-nrq4ncdf 671 9 the the DT cord-001397-nrq4ncdf 671 10 flavivirus flavivirus NNP cord-001397-nrq4ncdf 671 11 RNA RNA NNP cord-001397-nrq4ncdf 671 12 polymerase polymerase NN cord-001397-nrq4ncdf 671 13 xml xml NN cord-001397-nrq4ncdf 671 14 : : : cord-001397-nrq4ncdf 671 15 crystal crystal NN cord-001397-nrq4ncdf 671 16 structure structure NN cord-001397-nrq4ncdf 671 17 and and CC cord-001397-nrq4ncdf 671 18 functional functional JJ cord-001397-nrq4ncdf 671 19 characterization characterization NN cord-001397-nrq4ncdf 671 20 Interplay Interplay NNP cord-001397-nrq4ncdf 671 21 of of IN cord-001397-nrq4ncdf 671 22 RNA RNA NNP cord-001397-nrq4ncdf 671 23 elements element NNS cord-001397-nrq4ncdf 671 24 in in IN cord-001397-nrq4ncdf 671 25 the the DT cord-001397-nrq4ncdf 671 26 dengue dengue NN cord-001397-nrq4ncdf 671 27 virus virus NN cord-001397-nrq4ncdf 671 28 5 5 CD cord-001397-nrq4ncdf 671 29 0 0 CD cord-001397-nrq4ncdf 671 30 and and CC cord-001397-nrq4ncdf 671 31 3 3 CD cord-001397-nrq4ncdf 671 32 0 0 CD cord-001397-nrq4ncdf 671 33 ends end NNS cord-001397-nrq4ncdf 671 34 required require VBN cord-001397-nrq4ncdf 671 35 for for IN cord-001397-nrq4ncdf 671 36 viral viral JJ cord-001397-nrq4ncdf 671 37 RNA RNA NNP cord-001397-nrq4ncdf 671 38 replication replication NN cord-001397-nrq4ncdf 672 1 The the DT cord-001397-nrq4ncdf 672 2 5 5 CD cord-001397-nrq4ncdf 672 3 0 0 CD cord-001397-nrq4ncdf 672 4 and and CC cord-001397-nrq4ncdf 672 5 3 3 CD cord-001397-nrq4ncdf 672 6 0 0 CD cord-001397-nrq4ncdf 672 7 downstream downstream JJ cord-001397-nrq4ncdf 672 8 AUG AUG NNP cord-001397-nrq4ncdf 672 9 region region NN cord-001397-nrq4ncdf 672 10 elements element NNS cord-001397-nrq4ncdf 672 11 are be VBP cord-001397-nrq4ncdf 672 12 required require VBN cord-001397-nrq4ncdf 672 13 for for IN cord-001397-nrq4ncdf 672 14 mosquito mosquito NN cord-001397-nrq4ncdf 672 15 - - HYPH cord-001397-nrq4ncdf 672 16 borne bear VBN cord-001397-nrq4ncdf 672 17 flavivirus flavivirus NNP cord-001397-nrq4ncdf 672 18 RNA RNA NNP cord-001397-nrq4ncdf 672 19 replication replication NN cord-001397-nrq4ncdf 672 20 West West NNP cord-001397-nrq4ncdf 672 21 Nile Nile NNP cord-001397-nrq4ncdf 672 22 virus virus NN cord-001397-nrq4ncdf 672 23 RNA RNA NNP cord-001397-nrq4ncdf 672 24 not not RB cord-001397-nrq4ncdf 672 25 detected detect VBN cord-001397-nrq4ncdf 672 26 in in IN cord-001397-nrq4ncdf 672 27 urine urine NN cord-001397-nrq4ncdf 672 28 of of IN cord-001397-nrq4ncdf 672 29 40 40 CD cord-001397-nrq4ncdf 672 30 people people NNS cord-001397-nrq4ncdf 672 31 tested test VBN cord-001397-nrq4ncdf 672 32 6 6 CD cord-001397-nrq4ncdf 672 33 years year NNS cord-001397-nrq4ncdf 672 34 after after IN cord-001397-nrq4ncdf 672 35 acute acute JJ cord-001397-nrq4ncdf 672 36 West West NNP cord-001397-nrq4ncdf 672 37 Nile Nile NNP cord-001397-nrq4ncdf 672 38 virus virus NN cord-001397-nrq4ncdf 672 39 disease disease NN cord-001397-nrq4ncdf 672 40 The the DT cord-001397-nrq4ncdf 672 41 endoplasmic endoplasmic NN cord-001397-nrq4ncdf 672 42 reticulum reticulum NN cord-001397-nrq4ncdf 672 43 provides provide VBZ cord-001397-nrq4ncdf 672 44 the the DT cord-001397-nrq4ncdf 672 45 membrane membrane NN cord-001397-nrq4ncdf 672 46 platform platform NN cord-001397-nrq4ncdf 672 47 for for IN cord-001397-nrq4ncdf 672 48 biogenesis biogenesis NN cord-001397-nrq4ncdf 672 49 of of IN cord-001397-nrq4ncdf 672 50 the the DT cord-001397-nrq4ncdf 672 51 flavivirus flavivirus NNP cord-001397-nrq4ncdf 672 52 replication replication NN cord-001397-nrq4ncdf 672 53 complex complex JJ cord-001397-nrq4ncdf 672 54 West West NNP cord-001397-nrq4ncdf 672 55 Nile Nile NNP cord-001397-nrq4ncdf 672 56 virus virus NN cord-001397-nrq4ncdf 672 57 dissemination dissemination NN cord-001397-nrq4ncdf 672 58 and and CC cord-001397-nrq4ncdf 672 59 tissue tissue NN cord-001397-nrq4ncdf 672 60 tropisms tropism NNS cord-001397-nrq4ncdf 672 61 in in IN cord-001397-nrq4ncdf 672 62 orally orally RB cord-001397-nrq4ncdf 672 63 infected infect VBN cord-001397-nrq4ncdf 672 64 Culex Culex NNP cord-001397-nrq4ncdf 672 65 pipiens pipien NNS cord-001397-nrq4ncdf 672 66 quinquefasciatus quinquefasciatus NN cord-001397-nrq4ncdf 672 67 Ultrastructural Ultrastructural NNP cord-001397-nrq4ncdf 672 68 study study NN cord-001397-nrq4ncdf 672 69 of of IN cord-001397-nrq4ncdf 672 70 West West NNP cord-001397-nrq4ncdf 672 71 Nile Nile NNP cord-001397-nrq4ncdf 672 72 virus virus NN cord-001397-nrq4ncdf 672 73 pathogenesis pathogenesis NN cord-001397-nrq4ncdf 672 74 in in IN cord-001397-nrq4ncdf 672 75 Culex Culex NNP cord-001397-nrq4ncdf 672 76 pipiens pipien NNS cord-001397-nrq4ncdf 672 77 quinquefasciatus quinquefasciatus NNP cord-001397-nrq4ncdf 673 1 ( ( -LRB- cord-001397-nrq4ncdf 673 2 Diptera Diptera NNS cord-001397-nrq4ncdf 673 3 : : : cord-001397-nrq4ncdf 673 4 Culicidae Culicidae NNP cord-001397-nrq4ncdf 673 5 ) ) -RRB- cord-001397-nrq4ncdf 674 1 Poliomyelitis poliomyelitis NN cord-001397-nrq4ncdf 674 2 due due IN cord-001397-nrq4ncdf 674 3 to to IN cord-001397-nrq4ncdf 674 4 West West NNP cord-001397-nrq4ncdf 674 5 Nile Nile NNP cord-001397-nrq4ncdf 674 6 virus virus NN cord-001397-nrq4ncdf 674 7 Land land NN cord-001397-nrq4ncdf 674 8 use use NN cord-001397-nrq4ncdf 674 9 and and CC cord-001397-nrq4ncdf 674 10 West West NNP cord-001397-nrq4ncdf 674 11 Nile Nile NNP cord-001397-nrq4ncdf 674 12 virus virus NN cord-001397-nrq4ncdf 674 13 seroprevalence seroprevalence NN cord-001397-nrq4ncdf 674 14 in in IN cord-001397-nrq4ncdf 674 15 wild wild JJ cord-001397-nrq4ncdf 674 16 mammals mammal NNS cord-001397-nrq4ncdf 675 1 Flavivirus Flavivirus NNP cord-001397-nrq4ncdf 675 2 infections infection NNS cord-001397-nrq4ncdf 675 3 in in IN cord-001397-nrq4ncdf 675 4 humans human NNS cord-001397-nrq4ncdf 675 5 . . . cord-001397-nrq4ncdf 676 1 eLS eLS NNP cord-001397-nrq4ncdf 676 2 Genomics genomic NNS cord-001397-nrq4ncdf 676 3 and and CC cord-001397-nrq4ncdf 676 4 evolution evolution NN cord-001397-nrq4ncdf 676 5 of of IN cord-001397-nrq4ncdf 676 6 Aedes Aedes NNP cord-001397-nrq4ncdf 676 7 - - HYPH cord-001397-nrq4ncdf 676 8 borne bear VBN cord-001397-nrq4ncdf 676 9 flaviviruses flaviviruse VBZ cord-001397-nrq4ncdf 676 10 Direct Direct NNP cord-001397-nrq4ncdf 676 11 repeats repeat NNS cord-001397-nrq4ncdf 676 12 in in IN cord-001397-nrq4ncdf 676 13 the the DT cord-001397-nrq4ncdf 676 14 flavivirus flavivirus JJ cord-001397-nrq4ncdf 676 15 3 3 CD cord-001397-nrq4ncdf 676 16 0 0 CD cord-001397-nrq4ncdf 676 17 untranslated untranslated JJ cord-001397-nrq4ncdf 676 18 region region NN cord-001397-nrq4ncdf 676 19 ; ; : cord-001397-nrq4ncdf 676 20 a a DT cord-001397-nrq4ncdf 676 21 strategy strategy NN cord-001397-nrq4ncdf 676 22 for for IN cord-001397-nrq4ncdf 676 23 survival survival NN cord-001397-nrq4ncdf 676 24 in in IN cord-001397-nrq4ncdf 676 25 the the DT cord-001397-nrq4ncdf 676 26 environment environment NN cord-001397-nrq4ncdf 676 27 Origin origin NN cord-001397-nrq4ncdf 676 28 and and CC cord-001397-nrq4ncdf 676 29 evolution evolution NN cord-001397-nrq4ncdf 676 30 of of IN cord-001397-nrq4ncdf 676 31 3 3 CD cord-001397-nrq4ncdf 676 32 0 0 CD cord-001397-nrq4ncdf 676 33 UTR UTR NNP cord-001397-nrq4ncdf 676 34 of of IN cord-001397-nrq4ncdf 676 35 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 676 36 : : : cord-001397-nrq4ncdf 676 37 long long RB cord-001397-nrq4ncdf 676 38 direct direct JJ cord-001397-nrq4ncdf 676 39 repeats repeat NNS cord-001397-nrq4ncdf 676 40 as as IN cord-001397-nrq4ncdf 676 41 a a DT cord-001397-nrq4ncdf 676 42 basis basis NN cord-001397-nrq4ncdf 676 43 for for IN cord-001397-nrq4ncdf 676 44 the the DT cord-001397-nrq4ncdf 676 45 formation formation NN cord-001397-nrq4ncdf 676 46 of of IN cord-001397-nrq4ncdf 676 47 secondary secondary JJ cord-001397-nrq4ncdf 676 48 structures structure NNS cord-001397-nrq4ncdf 676 49 and and CC cord-001397-nrq4ncdf 676 50 their -PRON- PRP$ cord-001397-nrq4ncdf 676 51 significance significance NN cord-001397-nrq4ncdf 676 52 for for IN cord-001397-nrq4ncdf 676 53 virus virus NN cord-001397-nrq4ncdf 676 54 transmission transmission NN cord-001397-nrq4ncdf 676 55 Complete complete JJ cord-001397-nrq4ncdf 676 56 sequence sequence NN cord-001397-nrq4ncdf 676 57 of of IN cord-001397-nrq4ncdf 676 58 two two CD cord-001397-nrq4ncdf 676 59 tick tick VB cord-001397-nrq4ncdf 676 60 - - HYPH cord-001397-nrq4ncdf 676 61 borne bear VBN cord-001397-nrq4ncdf 676 62 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 676 63 isolated isolate VBN cord-001397-nrq4ncdf 676 64 from from IN cord-001397-nrq4ncdf 676 65 Siberia Siberia NNP cord-001397-nrq4ncdf 676 66 and and CC cord-001397-nrq4ncdf 676 67 the the DT cord-001397-nrq4ncdf 676 68 UK UK NNP cord-001397-nrq4ncdf 676 69 : : : cord-001397-nrq4ncdf 676 70 analysis analysis NN cord-001397-nrq4ncdf 676 71 and and CC cord-001397-nrq4ncdf 676 72 significance significance NN cord-001397-nrq4ncdf 676 73 of of IN cord-001397-nrq4ncdf 676 74 the the DT cord-001397-nrq4ncdf 676 75 5 5 CD cord-001397-nrq4ncdf 676 76 0 0 CD cord-001397-nrq4ncdf 676 77 and and CC cord-001397-nrq4ncdf 676 78 3 3 CD cord-001397-nrq4ncdf 676 79 0 0 CD cord-001397-nrq4ncdf 677 1 -UTRs -UTRs . cord-001397-nrq4ncdf 678 1 Characterization characterization NN cord-001397-nrq4ncdf 678 2 of of IN cord-001397-nrq4ncdf 678 3 a a DT cord-001397-nrq4ncdf 678 4 Siberian siberian JJ cord-001397-nrq4ncdf 678 5 virus virus NN cord-001397-nrq4ncdf 678 6 isolated isolate VBN cord-001397-nrq4ncdf 678 7 from from IN cord-001397-nrq4ncdf 678 8 a a DT cord-001397-nrq4ncdf 678 9 patient patient NN cord-001397-nrq4ncdf 678 10 with with IN cord-001397-nrq4ncdf 678 11 progressive progressive JJ cord-001397-nrq4ncdf 678 12 chronic chronic JJ cord-001397-nrq4ncdf 678 13 tick tick NN cord-001397-nrq4ncdf 678 14 - - HYPH cord-001397-nrq4ncdf 678 15 borne bear VBN cord-001397-nrq4ncdf 678 16 encephalitis encephalitis JJ cord-001397-nrq4ncdf 678 17 Clinicopathologic Clinicopathologic NNP cord-001397-nrq4ncdf 678 18 study study NN cord-001397-nrq4ncdf 678 19 and and CC cord-001397-nrq4ncdf 678 20 laboratory laboratory NN cord-001397-nrq4ncdf 678 21 diagnosis diagnosis NN cord-001397-nrq4ncdf 678 22 of of IN cord-001397-nrq4ncdf 678 23 23 23 CD cord-001397-nrq4ncdf 678 24 cases case NNS cord-001397-nrq4ncdf 678 25 with with IN cord-001397-nrq4ncdf 678 26 West West NNP cord-001397-nrq4ncdf 678 27 Nile Nile NNP cord-001397-nrq4ncdf 678 28 virus virus NN cord-001397-nrq4ncdf 678 29 encephalomyelitis encephalomyelitis NN cord-001397-nrq4ncdf 678 30 Atypical atypical JJ cord-001397-nrq4ncdf 678 31 manifestations manifestation NNS cord-001397-nrq4ncdf 678 32 of of IN cord-001397-nrq4ncdf 678 33 dengue dengue NN cord-001397-nrq4ncdf 678 34 Secreted secrete VBN cord-001397-nrq4ncdf 678 35 dengue dengue NN cord-001397-nrq4ncdf 678 36 virus virus NN cord-001397-nrq4ncdf 678 37 nonstructural nonstructural JJ cord-001397-nrq4ncdf 678 38 protein protein NN cord-001397-nrq4ncdf 678 39 NS1 NS1 NNPS cord-001397-nrq4ncdf 678 40 is be VBZ cord-001397-nrq4ncdf 678 41 an an DT cord-001397-nrq4ncdf 678 42 atypical atypical JJ cord-001397-nrq4ncdf 678 43 barrel barrel NN cord-001397-nrq4ncdf 678 44 - - HYPH cord-001397-nrq4ncdf 678 45 shaped shape VBN cord-001397-nrq4ncdf 678 46 high high JJ cord-001397-nrq4ncdf 678 47 - - HYPH cord-001397-nrq4ncdf 678 48 density density NN cord-001397-nrq4ncdf 678 49 lipoprotein lipoprotein NN cord-001397-nrq4ncdf 678 50 Tick tick NN cord-001397-nrq4ncdf 678 51 - - HYPH cord-001397-nrq4ncdf 678 52 borne bear VBN cord-001397-nrq4ncdf 678 53 encephalitis encephalitis NN cord-001397-nrq4ncdf 678 54 - - HYPH cord-001397-nrq4ncdf 678 55 pathogenesis pathogenesis NN cord-001397-nrq4ncdf 678 56 , , , cord-001397-nrq4ncdf 678 57 clinical clinical JJ cord-001397-nrq4ncdf 678 58 course course NN cord-001397-nrq4ncdf 678 59 and and CC cord-001397-nrq4ncdf 678 60 long long JJ cord-001397-nrq4ncdf 678 61 - - HYPH cord-001397-nrq4ncdf 678 62 term term NN cord-001397-nrq4ncdf 679 1 follow follow VB cord-001397-nrq4ncdf 679 2 - - HYPH cord-001397-nrq4ncdf 679 3 up up NN cord-001397-nrq4ncdf 680 1 A a DT cord-001397-nrq4ncdf 680 2 10-year 10-year CD cord-001397-nrq4ncdf 680 3 follow follow NN cord-001397-nrq4ncdf 680 4 - - HYPH cord-001397-nrq4ncdf 680 5 up up NN cord-001397-nrq4ncdf 680 6 study study NN cord-001397-nrq4ncdf 680 7 of of IN cord-001397-nrq4ncdf 680 8 tick tick NN cord-001397-nrq4ncdf 680 9 - - HYPH cord-001397-nrq4ncdf 680 10 borne bear VBN cord-001397-nrq4ncdf 680 11 encephalitis encephalitis RB cord-001397-nrq4ncdf 680 12 in in IN cord-001397-nrq4ncdf 680 13 the the DT cord-001397-nrq4ncdf 680 14 Stockholm Stockholm NNP cord-001397-nrq4ncdf 680 15 area area NN cord-001397-nrq4ncdf 680 16 and and CC cord-001397-nrq4ncdf 680 17 a a DT cord-001397-nrq4ncdf 680 18 review review NN cord-001397-nrq4ncdf 680 19 of of IN cord-001397-nrq4ncdf 680 20 the the DT cord-001397-nrq4ncdf 680 21 literature literature NN cord-001397-nrq4ncdf 680 22 : : : cord-001397-nrq4ncdf 680 23 need need VB cord-001397-nrq4ncdf 680 24 for for IN cord-001397-nrq4ncdf 680 25 a a DT cord-001397-nrq4ncdf 680 26 vaccination vaccination NN cord-001397-nrq4ncdf 680 27 strategy strategy NN cord-001397-nrq4ncdf 680 28 Conserved conserve VBN cord-001397-nrq4ncdf 680 29 elements element NNS cord-001397-nrq4ncdf 680 30 in in IN cord-001397-nrq4ncdf 680 31 the the DT cord-001397-nrq4ncdf 680 32 3 3 CD cord-001397-nrq4ncdf 680 33 0 0 CD cord-001397-nrq4ncdf 680 34 untranslated untranslated JJ cord-001397-nrq4ncdf 680 35 region region NN cord-001397-nrq4ncdf 680 36 of of IN cord-001397-nrq4ncdf 680 37 flavivirus flavivirus NNP cord-001397-nrq4ncdf 680 38 RNAs RNAs NNPS cord-001397-nrq4ncdf 680 39 and and CC cord-001397-nrq4ncdf 680 40 potential potential JJ cord-001397-nrq4ncdf 680 41 cyclization cyclization NN cord-001397-nrq4ncdf 681 1 sequences sequence NNS cord-001397-nrq4ncdf 681 2 Diverse diverse JJ cord-001397-nrq4ncdf 681 3 Borrelia Borrelia NNP cord-001397-nrq4ncdf 681 4 burgdorferi burgdorferi NN cord-001397-nrq4ncdf 681 5 strains strain NNS cord-001397-nrq4ncdf 681 6 in in IN cord-001397-nrq4ncdf 681 7 a a DT cord-001397-nrq4ncdf 681 8 bird bird NN cord-001397-nrq4ncdf 681 9 - - HYPH cord-001397-nrq4ncdf 681 10 tick tick NN cord-001397-nrq4ncdf 681 11 cryptic cryptic JJ cord-001397-nrq4ncdf 681 12 cycle cycle NN cord-001397-nrq4ncdf 681 13 Early early JJ cord-001397-nrq4ncdf 681 14 mortality mortality NN cord-001397-nrq4ncdf 681 15 following follow VBG cord-001397-nrq4ncdf 681 16 intracerebral intracerebral JJ cord-001397-nrq4ncdf 681 17 infection infection NN cord-001397-nrq4ncdf 681 18 with with IN cord-001397-nrq4ncdf 681 19 the the DT cord-001397-nrq4ncdf 681 20 Oshima Oshima NNP cord-001397-nrq4ncdf 681 21 strain strain NN cord-001397-nrq4ncdf 681 22 of of IN cord-001397-nrq4ncdf 681 23 tick tick NN cord-001397-nrq4ncdf 681 24 - - HYPH cord-001397-nrq4ncdf 681 25 borne bear VBN cord-001397-nrq4ncdf 681 26 encephalitis encephalitis JJ cord-001397-nrq4ncdf 681 27 virus virus NN cord-001397-nrq4ncdf 681 28 in in IN cord-001397-nrq4ncdf 681 29 a a DT cord-001397-nrq4ncdf 681 30 mouse mouse NN cord-001397-nrq4ncdf 681 31 model model NN cord-001397-nrq4ncdf 681 32 Structural structural JJ cord-001397-nrq4ncdf 681 33 changes change NNS cord-001397-nrq4ncdf 681 34 and and CC cord-001397-nrq4ncdf 681 35 functional functional JJ cord-001397-nrq4ncdf 681 36 control control NN cord-001397-nrq4ncdf 681 37 of of IN cord-001397-nrq4ncdf 681 38 the the DT cord-001397-nrq4ncdf 681 39 tick tick VB cord-001397-nrq4ncdf 681 40 - - HYPH cord-001397-nrq4ncdf 681 41 borne bear VBN cord-001397-nrq4ncdf 681 42 encephalitis encephalitis JJ cord-001397-nrq4ncdf 681 43 virus virus NN cord-001397-nrq4ncdf 681 44 glycoprotein glycoprotein NN cord-001397-nrq4ncdf 681 45 E e NN cord-001397-nrq4ncdf 681 46 by by IN cord-001397-nrq4ncdf 681 47 the the DT cord-001397-nrq4ncdf 681 48 heterodimeric heterodimeric NNP cord-001397-nrq4ncdf 681 49 association association NNP cord-001397-nrq4ncdf 681 50 with with IN cord-001397-nrq4ncdf 681 51 protein protein NN cord-001397-nrq4ncdf 681 52 prM prM NNP cord-001397-nrq4ncdf 681 53 Mutational Mutational NNP cord-001397-nrq4ncdf 681 54 analysis analysis NN cord-001397-nrq4ncdf 681 55 of of IN cord-001397-nrq4ncdf 681 56 a a DT cord-001397-nrq4ncdf 681 57 neutralization neutralization NN cord-001397-nrq4ncdf 681 58 epitope epitope NN cord-001397-nrq4ncdf 681 59 on on IN cord-001397-nrq4ncdf 681 60 the the DT cord-001397-nrq4ncdf 681 61 dengue dengue NN cord-001397-nrq4ncdf 681 62 type type NN cord-001397-nrq4ncdf 681 63 2 2 CD cord-001397-nrq4ncdf 681 64 virus virus NN cord-001397-nrq4ncdf 681 65 ( ( -LRB- cord-001397-nrq4ncdf 681 66 DEN2 DEN2 NNP cord-001397-nrq4ncdf 681 67 ) ) -RRB- cord-001397-nrq4ncdf 681 68 envelope envelope NN cord-001397-nrq4ncdf 681 69 protein protein NN cord-001397-nrq4ncdf 681 70 : : : cord-001397-nrq4ncdf 681 71 monoclonal monoclonal JJ cord-001397-nrq4ncdf 681 72 antibody antibody NN cord-001397-nrq4ncdf 682 1 resistant resistant JJ cord-001397-nrq4ncdf 682 2 DEN2 DEN2 NNP cord-001397-nrq4ncdf 682 3 / / SYM cord-001397-nrq4ncdf 682 4 DEN4 DEN4 NNP cord-001397-nrq4ncdf 682 5 chimeras chimera NNS cord-001397-nrq4ncdf 682 6 exhibit exhibit VBP cord-001397-nrq4ncdf 682 7 reduced reduce VBN cord-001397-nrq4ncdf 682 8 mouse mouse NN cord-001397-nrq4ncdf 682 9 neurovirulence neurovirulence NNP cord-001397-nrq4ncdf 683 1 An an DT cord-001397-nrq4ncdf 683 2 animal animal NN cord-001397-nrq4ncdf 683 3 model model NN cord-001397-nrq4ncdf 683 4 for for IN cord-001397-nrq4ncdf 683 5 the the DT cord-001397-nrq4ncdf 683 6 tickborne tickborne NNP cord-001397-nrq4ncdf 683 7 flavivirus flavivirus NNP cord-001397-nrq4ncdf 683 8 - - HYPH cord-001397-nrq4ncdf 683 9 Omsk Omsk NNP cord-001397-nrq4ncdf 683 10 hemorrhagic hemorrhagic JJ cord-001397-nrq4ncdf 683 11 fever fever NN cord-001397-nrq4ncdf 683 12 virus virus NN cord-001397-nrq4ncdf 684 1 A a DT cord-001397-nrq4ncdf 684 2 single single JJ cord-001397-nrq4ncdf 684 3 amino amino NN cord-001397-nrq4ncdf 684 4 acid acid NN cord-001397-nrq4ncdf 684 5 substitution substitution NN cord-001397-nrq4ncdf 684 6 in in IN cord-001397-nrq4ncdf 684 7 envelope envelope NN cord-001397-nrq4ncdf 684 8 protein protein NN cord-001397-nrq4ncdf 684 9 E e NN cord-001397-nrq4ncdf 684 10 of of IN cord-001397-nrq4ncdf 684 11 tick tick NN cord-001397-nrq4ncdf 684 12 - - HYPH cord-001397-nrq4ncdf 684 13 borne bear VBN cord-001397-nrq4ncdf 684 14 encephalitis encephalitis JJ cord-001397-nrq4ncdf 684 15 virus virus NN cord-001397-nrq4ncdf 684 16 leads lead VBZ cord-001397-nrq4ncdf 684 17 to to IN cord-001397-nrq4ncdf 684 18 attenuation attenuation NN cord-001397-nrq4ncdf 684 19 in in IN cord-001397-nrq4ncdf 684 20 the the DT cord-001397-nrq4ncdf 684 21 mouse mouse NN cord-001397-nrq4ncdf 684 22 model model NN cord-001397-nrq4ncdf 684 23 Tick tick NN cord-001397-nrq4ncdf 684 24 - - HYPH cord-001397-nrq4ncdf 684 25 borne bear VBN cord-001397-nrq4ncdf 684 26 encephalitis encephalitis RB cord-001397-nrq4ncdf 684 27 associated associate VBN cord-001397-nrq4ncdf 684 28 with with IN cord-001397-nrq4ncdf 684 29 consumption consumption NN cord-001397-nrq4ncdf 684 30 of of IN cord-001397-nrq4ncdf 684 31 raw raw JJ cord-001397-nrq4ncdf 684 32 goat goat NN cord-001397-nrq4ncdf 684 33 milk milk NN cord-001397-nrq4ncdf 684 34 West West NNP cord-001397-nrq4ncdf 684 35 Nile Nile NNP cord-001397-nrq4ncdf 684 36 and and CC cord-001397-nrq4ncdf 684 37 St St NNP cord-001397-nrq4ncdf 684 38 Louis Louis NNP cord-001397-nrq4ncdf 684 39 encephalitis encephalitis RB cord-001397-nrq4ncdf 684 40 virus virus NN cord-001397-nrq4ncdf 684 41 antibody antibody NN cord-001397-nrq4ncdf 684 42 seroconversion seroconversion NN cord-001397-nrq4ncdf 684 43 , , , cord-001397-nrq4ncdf 684 44 prevalence prevalence NN cord-001397-nrq4ncdf 684 45 , , , cord-001397-nrq4ncdf 684 46 and and CC cord-001397-nrq4ncdf 684 47 persistence persistence NN cord-001397-nrq4ncdf 684 48 in in IN cord-001397-nrq4ncdf 684 49 naturally naturally RB cord-001397-nrq4ncdf 684 50 infected infect VBN cord-001397-nrq4ncdf 684 51 pig pig NN cord-001397-nrq4ncdf 684 52 - - HYPH cord-001397-nrq4ncdf 684 53 tailed tail VBN cord-001397-nrq4ncdf 684 54 macaques macaque NNS cord-001397-nrq4ncdf 684 55 ( ( -LRB- cord-001397-nrq4ncdf 684 56 Macaca Macaca NNP cord-001397-nrq4ncdf 684 57 nemestrina nemestrina NNP cord-001397-nrq4ncdf 684 58 ) ) -RRB- cord-001397-nrq4ncdf 684 59 Control Control NNP cord-001397-nrq4ncdf 684 60 of of IN cord-001397-nrq4ncdf 684 61 Japanese Japanese NNP cord-001397-nrq4ncdf 684 62 encephalitis encephalitis RB cord-001397-nrq4ncdf 684 63 in in IN cord-001397-nrq4ncdf 684 64 Japan Japan NNP cord-001397-nrq4ncdf 684 65 : : : cord-001397-nrq4ncdf 684 66 immunization immunization NN cord-001397-nrq4ncdf 684 67 of of IN cord-001397-nrq4ncdf 684 68 humans human NNS cord-001397-nrq4ncdf 684 69 and and CC cord-001397-nrq4ncdf 684 70 animals animal NNS cord-001397-nrq4ncdf 684 71 , , , cord-001397-nrq4ncdf 684 72 and and CC cord-001397-nrq4ncdf 684 73 vector vector NN cord-001397-nrq4ncdf 684 74 control control NN cord-001397-nrq4ncdf 684 75 Apoptosis Apoptosis NNP cord-001397-nrq4ncdf 684 76 as as IN cord-001397-nrq4ncdf 684 77 a a DT cord-001397-nrq4ncdf 684 78 mechanism mechanism NN cord-001397-nrq4ncdf 684 79 for for IN cord-001397-nrq4ncdf 684 80 the the DT cord-001397-nrq4ncdf 684 81 cytopathic cytopathic JJ cord-001397-nrq4ncdf 684 82 action action NN cord-001397-nrq4ncdf 684 83 of of IN cord-001397-nrq4ncdf 684 84 tick tick NN cord-001397-nrq4ncdf 684 85 - - HYPH cord-001397-nrq4ncdf 684 86 borne bear VBN cord-001397-nrq4ncdf 684 87 encephalitis encephalitis JJ cord-001397-nrq4ncdf 684 88 virus virus NN cord-001397-nrq4ncdf 684 89 West West NNP cord-001397-nrq4ncdf 684 90 Nile Nile NNP cord-001397-nrq4ncdf 684 91 virus virus NN cord-001397-nrq4ncdf 684 92 infection infection NN cord-001397-nrq4ncdf 684 93 in in IN cord-001397-nrq4ncdf 684 94 farmed farm VBN cord-001397-nrq4ncdf 684 95 American american JJ cord-001397-nrq4ncdf 684 96 alligators alligator NNS cord-001397-nrq4ncdf 684 97 ( ( -LRB- cord-001397-nrq4ncdf 684 98 Alligator Alligator NNP cord-001397-nrq4ncdf 684 99 mississippiensis mississippiensis NN cord-001397-nrq4ncdf 684 100 ) ) -RRB- cord-001397-nrq4ncdf 684 101 in in IN cord-001397-nrq4ncdf 684 102 Florida Florida NNP cord-001397-nrq4ncdf 685 1 Why why WRB cord-001397-nrq4ncdf 685 2 is be VBZ cord-001397-nrq4ncdf 685 3 tick tick VB cord-001397-nrq4ncdf 685 4 - - HYPH cord-001397-nrq4ncdf 685 5 borne bear VBN cord-001397-nrq4ncdf 685 6 encephalitis encephalitis RB cord-001397-nrq4ncdf 685 7 increasing increase VBG cord-001397-nrq4ncdf 685 8 ? ? . cord-001397-nrq4ncdf 686 1 A a DT cord-001397-nrq4ncdf 686 2 review review NN cord-001397-nrq4ncdf 686 3 of of IN cord-001397-nrq4ncdf 686 4 the the DT cord-001397-nrq4ncdf 686 5 key key JJ cord-001397-nrq4ncdf 686 6 factors factor NNS cord-001397-nrq4ncdf 686 7 causing cause VBG cord-001397-nrq4ncdf 686 8 the the DT cord-001397-nrq4ncdf 686 9 increasing increase VBG cord-001397-nrq4ncdf 686 10 incidence incidence NN cord-001397-nrq4ncdf 686 11 of of IN cord-001397-nrq4ncdf 686 12 human human JJ cord-001397-nrq4ncdf 686 13 TBE tbe NN cord-001397-nrq4ncdf 686 14 in in IN cord-001397-nrq4ncdf 686 15 Sweden Sweden NNP cord-001397-nrq4ncdf 686 16 Polypyrimidine Polypyrimidine NNP cord-001397-nrq4ncdf 686 17 tract tract NN cord-001397-nrq4ncdf 686 18 - - HYPH cord-001397-nrq4ncdf 686 19 binding bind VBG cord-001397-nrq4ncdf 686 20 protein protein NN cord-001397-nrq4ncdf 686 21 influences influence VBZ cord-001397-nrq4ncdf 686 22 negative negative JJ cord-001397-nrq4ncdf 686 23 strand strand NN cord-001397-nrq4ncdf 686 24 RNA RNA NNP cord-001397-nrq4ncdf 686 25 synthesis synthesis NN cord-001397-nrq4ncdf 686 26 of of IN cord-001397-nrq4ncdf 686 27 dengue dengue NN cord-001397-nrq4ncdf 686 28 virus virus NN cord-001397-nrq4ncdf 687 1 A a DT cord-001397-nrq4ncdf 687 2 small small JJ cord-001397-nrq4ncdf 687 3 region region NN cord-001397-nrq4ncdf 687 4 of of IN cord-001397-nrq4ncdf 687 5 the the DT cord-001397-nrq4ncdf 687 6 dengue dengue NN cord-001397-nrq4ncdf 687 7 virus virus NN cord-001397-nrq4ncdf 687 8 - - HYPH cord-001397-nrq4ncdf 687 9 encoded encode VBN cord-001397-nrq4ncdf 687 10 RNA rna NN cord-001397-nrq4ncdf 687 11 - - HYPH cord-001397-nrq4ncdf 687 12 dependent dependent JJ cord-001397-nrq4ncdf 687 13 RNA RNA NNP cord-001397-nrq4ncdf 687 14 polymerase polymerase NN cord-001397-nrq4ncdf 687 15 , , , cord-001397-nrq4ncdf 687 16 NS5 ns5 JJ cord-001397-nrq4ncdf 687 17 , , , cord-001397-nrq4ncdf 687 18 confers confer VBZ cord-001397-nrq4ncdf 687 19 interaction interaction NN cord-001397-nrq4ncdf 687 20 with with IN cord-001397-nrq4ncdf 687 21 both both CC cord-001397-nrq4ncdf 687 22 the the DT cord-001397-nrq4ncdf 687 23 nuclear nuclear JJ cord-001397-nrq4ncdf 687 24 transport transport NN cord-001397-nrq4ncdf 687 25 receptor receptor NN cord-001397-nrq4ncdf 687 26 importin importin NN cord-001397-nrq4ncdf 687 27 - - HYPH cord-001397-nrq4ncdf 687 28 beta beta NN cord-001397-nrq4ncdf 687 29 and and CC cord-001397-nrq4ncdf 687 30 the the DT cord-001397-nrq4ncdf 687 31 viral viral JJ cord-001397-nrq4ncdf 687 32 helicase helicase NN cord-001397-nrq4ncdf 687 33 , , , cord-001397-nrq4ncdf 687 34 NS3 ns3 RB cord-001397-nrq4ncdf 687 35 Flavivirus Flavivirus NNP cord-001397-nrq4ncdf 687 36 capsid capsid NN cord-001397-nrq4ncdf 687 37 is be VBZ cord-001397-nrq4ncdf 687 38 a a DT cord-001397-nrq4ncdf 687 39 dimeric dimeric JJ cord-001397-nrq4ncdf 687 40 alpha alpha JJ cord-001397-nrq4ncdf 687 41 - - HYPH cord-001397-nrq4ncdf 687 42 helical helical JJ cord-001397-nrq4ncdf 687 43 protein protein NN cord-001397-nrq4ncdf 687 44 Crystal Crystal NNP cord-001397-nrq4ncdf 687 45 structure structure NN cord-001397-nrq4ncdf 687 46 of of IN cord-001397-nrq4ncdf 687 47 West West NNP cord-001397-nrq4ncdf 687 48 Nile Nile NNP cord-001397-nrq4ncdf 687 49 virus virus NN cord-001397-nrq4ncdf 687 50 envelope envelope NN cord-001397-nrq4ncdf 687 51 glycoprotein glycoprotein NN cord-001397-nrq4ncdf 687 52 reveals reveal VBZ cord-001397-nrq4ncdf 687 53 viral viral JJ cord-001397-nrq4ncdf 687 54 surface surface NN cord-001397-nrq4ncdf 687 55 epitopes epitope NNS cord-001397-nrq4ncdf 687 56 Persistence Persistence NNP cord-001397-nrq4ncdf 687 57 of of IN cord-001397-nrq4ncdf 687 58 West West NNP cord-001397-nrq4ncdf 687 59 Nile Nile NNP cord-001397-nrq4ncdf 687 60 Virus Virus NNP cord-001397-nrq4ncdf 687 61 ( ( -LRB- cord-001397-nrq4ncdf 687 62 WNV WNV NNP cord-001397-nrq4ncdf 687 63 ) ) -RRB- cord-001397-nrq4ncdf 687 64 IgM IgM NNP cord-001397-nrq4ncdf 687 65 antibodies antibody NNS cord-001397-nrq4ncdf 687 66 in in IN cord-001397-nrq4ncdf 687 67 cerebrospinal cerebrospinal JJ cord-001397-nrq4ncdf 687 68 fluid fluid NN cord-001397-nrq4ncdf 687 69 from from IN cord-001397-nrq4ncdf 687 70 patients patient NNS cord-001397-nrq4ncdf 687 71 with with IN cord-001397-nrq4ncdf 687 72 CNS CNS NNP cord-001397-nrq4ncdf 687 73 disease disease NN cord-001397-nrq4ncdf 687 74 Significance significance NN cord-001397-nrq4ncdf 687 75 in in IN cord-001397-nrq4ncdf 687 76 replication replication NN cord-001397-nrq4ncdf 687 77 of of IN cord-001397-nrq4ncdf 687 78 the the DT cord-001397-nrq4ncdf 687 79 terminal terminal JJ cord-001397-nrq4ncdf 687 80 nucleotides nucleotide NNS cord-001397-nrq4ncdf 687 81 of of IN cord-001397-nrq4ncdf 687 82 the the DT cord-001397-nrq4ncdf 687 83 flavivirus flavivirus NNP cord-001397-nrq4ncdf 687 84 genome genome NN cord-001397-nrq4ncdf 687 85 Host Host NNP cord-001397-nrq4ncdf 687 86 heterogeneity heterogeneity NN cord-001397-nrq4ncdf 687 87 dominates dominate VBZ cord-001397-nrq4ncdf 687 88 West West NNP cord-001397-nrq4ncdf 687 89 Nile Nile NNP cord-001397-nrq4ncdf 687 90 virus virus NN cord-001397-nrq4ncdf 687 91 transmission transmission NN cord-001397-nrq4ncdf 687 92 A a DT cord-001397-nrq4ncdf 687 93 single single JJ cord-001397-nrq4ncdf 687 94 N n NN cord-001397-nrq4ncdf 687 95 - - HYPH cord-001397-nrq4ncdf 687 96 linked link VBN cord-001397-nrq4ncdf 687 97 glycosylation glycosylation NN cord-001397-nrq4ncdf 687 98 site site NN cord-001397-nrq4ncdf 687 99 in in IN cord-001397-nrq4ncdf 687 100 the the DT cord-001397-nrq4ncdf 687 101 Japanese japanese JJ cord-001397-nrq4ncdf 687 102 encephalitis encephalitis RB cord-001397-nrq4ncdf 687 103 virus virus NN cord-001397-nrq4ncdf 687 104 prM prm JJ cord-001397-nrq4ncdf 687 105 protein protein NN cord-001397-nrq4ncdf 687 106 is be VBZ cord-001397-nrq4ncdf 687 107 critical critical JJ cord-001397-nrq4ncdf 687 108 for for IN cord-001397-nrq4ncdf 687 109 cell cell NN cord-001397-nrq4ncdf 687 110 type type NN cord-001397-nrq4ncdf 687 111 - - HYPH cord-001397-nrq4ncdf 687 112 specific specific JJ cord-001397-nrq4ncdf 687 113 prM prm JJ cord-001397-nrq4ncdf 687 114 protein protein NN cord-001397-nrq4ncdf 687 115 biogenesis biogenesis NN cord-001397-nrq4ncdf 687 116 , , , cord-001397-nrq4ncdf 687 117 virus virus NN cord-001397-nrq4ncdf 687 118 particle particle NN cord-001397-nrq4ncdf 687 119 release release NN cord-001397-nrq4ncdf 687 120 , , , cord-001397-nrq4ncdf 687 121 and and CC cord-001397-nrq4ncdf 687 122 pathogenicity pathogenicity NN cord-001397-nrq4ncdf 687 123 in in IN cord-001397-nrq4ncdf 687 124 mice mouse NNS cord-001397-nrq4ncdf 688 1 Flavivirus Flavivirus NNP cord-001397-nrq4ncdf 688 2 encephalitis encephalitis RB cord-001397-nrq4ncdf 688 3 : : : cord-001397-nrq4ncdf 688 4 pathological pathological JJ cord-001397-nrq4ncdf 688 5 aspects aspect NNS cord-001397-nrq4ncdf 688 6 of of IN cord-001397-nrq4ncdf 688 7 mouse mouse NN cord-001397-nrq4ncdf 688 8 and and CC cord-001397-nrq4ncdf 688 9 other other JJ cord-001397-nrq4ncdf 688 10 animal animal NN cord-001397-nrq4ncdf 688 11 models model NNS cord-001397-nrq4ncdf 688 12 Goats goat NNS cord-001397-nrq4ncdf 688 13 and and CC cord-001397-nrq4ncdf 688 14 sheep sheep NNS cord-001397-nrq4ncdf 688 15 as as IN cord-001397-nrq4ncdf 688 16 sentinels sentinel NNS cord-001397-nrq4ncdf 688 17 for for IN cord-001397-nrq4ncdf 688 18 tick tick VB cord-001397-nrq4ncdf 688 19 - - HYPH cord-001397-nrq4ncdf 688 20 borne bear VBN cord-001397-nrq4ncdf 688 21 encephalitis encephalitis RB cord-001397-nrq4ncdf 689 1 ( ( -LRB- cord-001397-nrq4ncdf 689 2 TBE TBE NNP cord-001397-nrq4ncdf 689 3 ) ) -RRB- cord-001397-nrq4ncdf 689 4 virus virus NN cord-001397-nrq4ncdf 689 5 - - HYPH cord-001397-nrq4ncdf 689 6 epidemiological epidemiological JJ cord-001397-nrq4ncdf 689 7 studies study NNS cord-001397-nrq4ncdf 689 8 in in IN cord-001397-nrq4ncdf 689 9 areas area NNS cord-001397-nrq4ncdf 689 10 endemic endemic JJ cord-001397-nrq4ncdf 689 11 and and CC cord-001397-nrq4ncdf 689 12 non non JJ cord-001397-nrq4ncdf 689 13 - - JJ cord-001397-nrq4ncdf 689 14 endemic endemic JJ cord-001397-nrq4ncdf 689 15 for for IN cord-001397-nrq4ncdf 689 16 TBE TBE NNP cord-001397-nrq4ncdf 689 17 virus virus NN cord-001397-nrq4ncdf 689 18 in in IN cord-001397-nrq4ncdf 689 19 Germany Germany NNP cord-001397-nrq4ncdf 689 20 Patterns Patterns NNPS cord-001397-nrq4ncdf 689 21 of of IN cord-001397-nrq4ncdf 689 22 tick tick NN cord-001397-nrq4ncdf 689 23 - - HYPH cord-001397-nrq4ncdf 689 24 borne bear VBN cord-001397-nrq4ncdf 689 25 encephalitis encephalitis JJ cord-001397-nrq4ncdf 689 26 virus virus NN cord-001397-nrq4ncdf 689 27 infection infection NN cord-001397-nrq4ncdf 689 28 in in IN cord-001397-nrq4ncdf 689 29 rodents rodent NNS cord-001397-nrq4ncdf 689 30 in in IN cord-001397-nrq4ncdf 689 31 Slovenia Slovenia NNP cord-001397-nrq4ncdf 690 1 Capsid capsid JJ cord-001397-nrq4ncdf 690 2 protein protein NN cord-001397-nrq4ncdf 690 3 C c NN cord-001397-nrq4ncdf 690 4 of of IN cord-001397-nrq4ncdf 690 5 tick tick NN cord-001397-nrq4ncdf 690 6 - - HYPH cord-001397-nrq4ncdf 690 7 borne bear VBN cord-001397-nrq4ncdf 690 8 encephalitis encephalitis JJ cord-001397-nrq4ncdf 690 9 virus virus NN cord-001397-nrq4ncdf 690 10 tolerates tolerate VBZ cord-001397-nrq4ncdf 690 11 large large JJ cord-001397-nrq4ncdf 690 12 internal internal JJ cord-001397-nrq4ncdf 690 13 deletions deletion NNS cord-001397-nrq4ncdf 690 14 and and CC cord-001397-nrq4ncdf 690 15 is be VBZ cord-001397-nrq4ncdf 690 16 a a DT cord-001397-nrq4ncdf 690 17 favorable favorable JJ cord-001397-nrq4ncdf 690 18 target target NN cord-001397-nrq4ncdf 690 19 for for IN cord-001397-nrq4ncdf 690 20 attenuation attenuation NN cord-001397-nrq4ncdf 690 21 of of IN cord-001397-nrq4ncdf 690 22 virulence virulence NN cord-001397-nrq4ncdf 690 23 Functional functional JJ cord-001397-nrq4ncdf 690 24 analysis analysis NN cord-001397-nrq4ncdf 690 25 of of IN cord-001397-nrq4ncdf 690 26 the the DT cord-001397-nrq4ncdf 690 27 tick tick VB cord-001397-nrq4ncdf 690 28 - - HYPH cord-001397-nrq4ncdf 690 29 borne bear VBN cord-001397-nrq4ncdf 690 30 encephalitis encephalitis JJ cord-001397-nrq4ncdf 690 31 virus virus NN cord-001397-nrq4ncdf 690 32 cyclization cyclization NN cord-001397-nrq4ncdf 690 33 elements element NNS cord-001397-nrq4ncdf 690 34 indicates indicate VBZ cord-001397-nrq4ncdf 690 35 major major JJ cord-001397-nrq4ncdf 690 36 differences difference NNS cord-001397-nrq4ncdf 690 37 between between IN cord-001397-nrq4ncdf 690 38 mosquito mosquito NN cord-001397-nrq4ncdf 690 39 - - HYPH cord-001397-nrq4ncdf 690 40 borne bear VBN cord-001397-nrq4ncdf 690 41 and and CC cord-001397-nrq4ncdf 690 42 tick tick VB cord-001397-nrq4ncdf 690 43 - - HYPH cord-001397-nrq4ncdf 690 44 borne bear VBN cord-001397-nrq4ncdf 690 45 flaviviruses flaviviruse VBZ cord-001397-nrq4ncdf 690 46 Experimental experimental JJ cord-001397-nrq4ncdf 690 47 infection infection NN cord-001397-nrq4ncdf 690 48 of of IN cord-001397-nrq4ncdf 690 49 North north JJ cord-001397-nrq4ncdf 690 50 American american JJ cord-001397-nrq4ncdf 690 51 birds bird NNS cord-001397-nrq4ncdf 690 52 with with IN cord-001397-nrq4ncdf 690 53 the the DT cord-001397-nrq4ncdf 690 54 New New NNP cord-001397-nrq4ncdf 690 55 York York NNP cord-001397-nrq4ncdf 690 56 1999 1999 CD cord-001397-nrq4ncdf 690 57 strain strain NN cord-001397-nrq4ncdf 690 58 of of IN cord-001397-nrq4ncdf 690 59 West West NNP cord-001397-nrq4ncdf 690 60 Nile Nile NNP cord-001397-nrq4ncdf 690 61 virus virus NN cord-001397-nrq4ncdf 690 62 Antibodies antibody NNS cord-001397-nrq4ncdf 690 63 protect protect VBP cord-001397-nrq4ncdf 690 64 mice mouse NNS cord-001397-nrq4ncdf 690 65 against against IN cord-001397-nrq4ncdf 690 66 challenge challenge NN cord-001397-nrq4ncdf 690 67 with with IN cord-001397-nrq4ncdf 690 68 tick tick NN cord-001397-nrq4ncdf 690 69 - - HYPH cord-001397-nrq4ncdf 690 70 borne bear VBN cord-001397-nrq4ncdf 690 71 encephalitis encephalitis JJ cord-001397-nrq4ncdf 690 72 virus virus NN cord-001397-nrq4ncdf 690 73 ( ( -LRB- cord-001397-nrq4ncdf 690 74 TBEV)-infected tbev)-infecte VBN cord-001397-nrq4ncdf 690 75 macrophages macrophage VBZ cord-001397-nrq4ncdf 690 76 Structure Structure NNP cord-001397-nrq4ncdf 690 77 of of IN cord-001397-nrq4ncdf 690 78 dengue dengue NN cord-001397-nrq4ncdf 690 79 virus virus NN cord-001397-nrq4ncdf 690 80 : : : cord-001397-nrq4ncdf 690 81 implications implication NNS cord-001397-nrq4ncdf 690 82 for for IN cord-001397-nrq4ncdf 690 83 flavivirus flavivirus NNP cord-001397-nrq4ncdf 690 84 organization organization NN cord-001397-nrq4ncdf 690 85 , , , cord-001397-nrq4ncdf 690 86 maturation maturation NN cord-001397-nrq4ncdf 690 87 , , , cord-001397-nrq4ncdf 690 88 and and CC cord-001397-nrq4ncdf 690 89 fusion fusion NN cord-001397-nrq4ncdf 690 90 Amplification amplification NN cord-001397-nrq4ncdf 690 91 of of IN cord-001397-nrq4ncdf 690 92 tick tick NN cord-001397-nrq4ncdf 690 93 - - HYPH cord-001397-nrq4ncdf 690 94 borne bear VBN cord-001397-nrq4ncdf 690 95 encephalitis encephalitis JJ cord-001397-nrq4ncdf 690 96 virus virus NN cord-001397-nrq4ncdf 690 97 infection infection NN cord-001397-nrq4ncdf 690 98 during during IN cord-001397-nrq4ncdf 690 99 co co NN cord-001397-nrq4ncdf 690 100 - - NN cord-001397-nrq4ncdf 690 101 feeding feeding NN cord-001397-nrq4ncdf 690 102 of of IN cord-001397-nrq4ncdf 690 103 ticks tick NNS cord-001397-nrq4ncdf 690 104 Efficient efficient JJ cord-001397-nrq4ncdf 690 105 transmission transmission NN cord-001397-nrq4ncdf 690 106 of of IN cord-001397-nrq4ncdf 690 107 tick tick NN cord-001397-nrq4ncdf 690 108 - - HYPH cord-001397-nrq4ncdf 690 109 borne bear VBN cord-001397-nrq4ncdf 690 110 encephalitis encephalitis JJ cord-001397-nrq4ncdf 690 111 virus virus NN cord-001397-nrq4ncdf 690 112 between between IN cord-001397-nrq4ncdf 690 113 cofeeding cofeede VBG cord-001397-nrq4ncdf 690 114 ticks tick NNS cord-001397-nrq4ncdf 690 115 Importance importance NN cord-001397-nrq4ncdf 690 116 of of IN cord-001397-nrq4ncdf 690 117 localized localized JJ cord-001397-nrq4ncdf 690 118 skin skin NN cord-001397-nrq4ncdf 690 119 infection infection NN cord-001397-nrq4ncdf 690 120 in in IN cord-001397-nrq4ncdf 690 121 tick tick NN cord-001397-nrq4ncdf 690 122 - - HYPH cord-001397-nrq4ncdf 690 123 borne bear VBN cord-001397-nrq4ncdf 690 124 encephalitis encephalitis JJ cord-001397-nrq4ncdf 690 125 virus virus NN cord-001397-nrq4ncdf 690 126 transmission transmission NN cord-001397-nrq4ncdf 690 127 Characterization characterization NN cord-001397-nrq4ncdf 690 128 of of IN cord-001397-nrq4ncdf 690 129 defective defective JJ cord-001397-nrq4ncdf 690 130 viral viral JJ cord-001397-nrq4ncdf 690 131 RNA RNA NNP cord-001397-nrq4ncdf 690 132 produced produce VBN cord-001397-nrq4ncdf 690 133 during during IN cord-001397-nrq4ncdf 690 134 persistent persistent JJ cord-001397-nrq4ncdf 690 135 infection infection NN cord-001397-nrq4ncdf 690 136 of of IN cord-001397-nrq4ncdf 690 137 Vero Vero NNP cord-001397-nrq4ncdf 690 138 cells cell NNS cord-001397-nrq4ncdf 690 139 with with IN cord-001397-nrq4ncdf 690 140 Murray Murray NNP cord-001397-nrq4ncdf 690 141 Valley Valley NNP cord-001397-nrq4ncdf 690 142 encephalitis encephalitis NN cord-001397-nrq4ncdf 690 143 virus virus NN cord-001397-nrq4ncdf 690 144 Common Common NNP cord-001397-nrq4ncdf 690 145 E E NNP cord-001397-nrq4ncdf 690 146 protein protein NN cord-001397-nrq4ncdf 690 147 determinants determinant NNS cord-001397-nrq4ncdf 690 148 for for IN cord-001397-nrq4ncdf 690 149 attenuation attenuation NN cord-001397-nrq4ncdf 690 150 of of IN cord-001397-nrq4ncdf 690 151 glycosaminoglycan glycosaminoglycan NN cord-001397-nrq4ncdf 690 152 - - HYPH cord-001397-nrq4ncdf 690 153 binding bind VBG cord-001397-nrq4ncdf 690 154 variants variant NNS cord-001397-nrq4ncdf 690 155 of of IN cord-001397-nrq4ncdf 690 156 Japanese japanese JJ cord-001397-nrq4ncdf 690 157 encephalitis encephalitis RB cord-001397-nrq4ncdf 690 158 and and CC cord-001397-nrq4ncdf 690 159 West West NNP cord-001397-nrq4ncdf 690 160 Nile Nile NNP cord-001397-nrq4ncdf 691 1 viruses virus NNS cord-001397-nrq4ncdf 692 1 Flavivirus Flavivirus NNP cord-001397-nrq4ncdf 692 2 activates activate VBZ cord-001397-nrq4ncdf 692 3 phosphatidylinositol phosphatidylinositol JJ cord-001397-nrq4ncdf 692 4 3-kinase 3-kinase CD cord-001397-nrq4ncdf 692 5 signaling signal VBG cord-001397-nrq4ncdf 692 6 to to IN cord-001397-nrq4ncdf 692 7 block block VB cord-001397-nrq4ncdf 692 8 caspase caspase NN cord-001397-nrq4ncdf 692 9 - - HYPH cord-001397-nrq4ncdf 692 10 dependent dependent JJ cord-001397-nrq4ncdf 692 11 apoptotic apoptotic JJ cord-001397-nrq4ncdf 692 12 cell cell NN cord-001397-nrq4ncdf 692 13 death death NN cord-001397-nrq4ncdf 692 14 at at IN cord-001397-nrq4ncdf 692 15 the the DT cord-001397-nrq4ncdf 692 16 early early JJ cord-001397-nrq4ncdf 692 17 stage stage NN cord-001397-nrq4ncdf 692 18 of of IN cord-001397-nrq4ncdf 692 19 virus virus NN cord-001397-nrq4ncdf 692 20 infection infection NN cord-001397-nrq4ncdf 692 21 Virulence virulence NN cord-001397-nrq4ncdf 692 22 attenuation attenuation NN cord-001397-nrq4ncdf 692 23 of of IN cord-001397-nrq4ncdf 692 24 Dengue Dengue NNP cord-001397-nrq4ncdf 692 25 virus virus NN cord-001397-nrq4ncdf 692 26 due due IN cord-001397-nrq4ncdf 692 27 to to IN cord-001397-nrq4ncdf 692 28 augmented augment VBN cord-001397-nrq4ncdf 692 29 glycosaminoglycan glycosaminoglycan NN cord-001397-nrq4ncdf 692 30 - - HYPH cord-001397-nrq4ncdf 692 31 binding bind VBG cord-001397-nrq4ncdf 692 32 affinity affinity NN cord-001397-nrq4ncdf 692 33 and and CC cord-001397-nrq4ncdf 692 34 restriction restriction NN cord-001397-nrq4ncdf 692 35 in in IN cord-001397-nrq4ncdf 692 36 extraneural extraneural JJ cord-001397-nrq4ncdf 692 37 dissemination dissemination NN cord-001397-nrq4ncdf 692 38 Towards towards IN cord-001397-nrq4ncdf 692 39 the the DT cord-001397-nrq4ncdf 692 40 design design NN cord-001397-nrq4ncdf 692 41 of of IN cord-001397-nrq4ncdf 692 42 antiviral antiviral JJ cord-001397-nrq4ncdf 692 43 inhibitors inhibitor NNS cord-001397-nrq4ncdf 692 44 against against IN cord-001397-nrq4ncdf 692 45 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 692 46 : : : cord-001397-nrq4ncdf 692 47 the the DT cord-001397-nrq4ncdf 692 48 case case NN cord-001397-nrq4ncdf 692 49 for for IN cord-001397-nrq4ncdf 692 50 the the DT cord-001397-nrq4ncdf 692 51 multifunctional multifunctional JJ cord-001397-nrq4ncdf 692 52 NS3 ns3 RB cord-001397-nrq4ncdf 692 53 protein protein NN cord-001397-nrq4ncdf 692 54 from from IN cord-001397-nrq4ncdf 692 55 Dengue Dengue NNP cord-001397-nrq4ncdf 692 56 virus virus NN cord-001397-nrq4ncdf 692 57 as as IN cord-001397-nrq4ncdf 692 58 a a DT cord-001397-nrq4ncdf 692 59 target target NN cord-001397-nrq4ncdf 692 60 Defective defective JJ cord-001397-nrq4ncdf 692 61 interfering interfere VBG cord-001397-nrq4ncdf 692 62 viral viral JJ cord-001397-nrq4ncdf 692 63 particles particle NNS cord-001397-nrq4ncdf 692 64 in in IN cord-001397-nrq4ncdf 692 65 acute acute JJ cord-001397-nrq4ncdf 692 66 Dengue Dengue NNP cord-001397-nrq4ncdf 692 67 infections infection NNS cord-001397-nrq4ncdf 693 1 Antiapoptotic Antiapoptotic NNP cord-001397-nrq4ncdf 693 2 but but CC cord-001397-nrq4ncdf 693 3 not not RB cord-001397-nrq4ncdf 693 4 antiviral antiviral JJ cord-001397-nrq4ncdf 693 5 function function NN cord-001397-nrq4ncdf 693 6 of of IN cord-001397-nrq4ncdf 693 7 human human JJ cord-001397-nrq4ncdf 693 8 bcl-2 bcl-2 NNP cord-001397-nrq4ncdf 693 9 assists assist VBZ cord-001397-nrq4ncdf 693 10 establishment establishment NN cord-001397-nrq4ncdf 693 11 of of IN cord-001397-nrq4ncdf 693 12 Japanese japanese JJ cord-001397-nrq4ncdf 693 13 encephalitis encephalitis RB cord-001397-nrq4ncdf 693 14 virus virus NN cord-001397-nrq4ncdf 693 15 persistence persistence NN cord-001397-nrq4ncdf 693 16 in in IN cord-001397-nrq4ncdf 693 17 cultured cultured JJ cord-001397-nrq4ncdf 693 18 cells cell NNS cord-001397-nrq4ncdf 693 19 Cleavage cleavage VBP cord-001397-nrq4ncdf 693 20 at at IN cord-001397-nrq4ncdf 693 21 a a DT cord-001397-nrq4ncdf 693 22 novel novel JJ cord-001397-nrq4ncdf 693 23 site site NN cord-001397-nrq4ncdf 693 24 in in IN cord-001397-nrq4ncdf 693 25 the the DT cord-001397-nrq4ncdf 693 26 NS4A NS4A NNP cord-001397-nrq4ncdf 693 27 region region NN cord-001397-nrq4ncdf 693 28 by by IN cord-001397-nrq4ncdf 693 29 the the DT cord-001397-nrq4ncdf 693 30 yellow yellow JJ cord-001397-nrq4ncdf 693 31 fever fever NN cord-001397-nrq4ncdf 693 32 virus virus NN cord-001397-nrq4ncdf 693 33 NS2B-3 NS2B-3 NNP cord-001397-nrq4ncdf 693 34 proteinase proteinase NN cord-001397-nrq4ncdf 693 35 is be VBZ cord-001397-nrq4ncdf 693 36 a a DT cord-001397-nrq4ncdf 693 37 prerequisite prerequisite NN cord-001397-nrq4ncdf 693 38 for for IN cord-001397-nrq4ncdf 693 39 processing processing NN cord-001397-nrq4ncdf 693 40 at at IN cord-001397-nrq4ncdf 693 41 the the DT cord-001397-nrq4ncdf 693 42 downstream downstream JJ cord-001397-nrq4ncdf 693 43 4A/ 4a/ CD cord-001397-nrq4ncdf 693 44 4B 4b CD cord-001397-nrq4ncdf 693 45 signalase signalase NN cord-001397-nrq4ncdf 693 46 site site NN cord-001397-nrq4ncdf 693 47 Blocking blocking NN cord-001397-nrq4ncdf 693 48 of of IN cord-001397-nrq4ncdf 693 49 the the DT cord-001397-nrq4ncdf 693 50 alpha alpha NN cord-001397-nrq4ncdf 693 51 interferon interferon NN cord-001397-nrq4ncdf 693 52 - - HYPH cord-001397-nrq4ncdf 693 53 induced induce VBN cord-001397-nrq4ncdf 693 54 Jak Jak NNP cord-001397-nrq4ncdf 693 55 - - HYPH cord-001397-nrq4ncdf 693 56 Stat Stat NNP cord-001397-nrq4ncdf 693 57 signaling signal VBG cord-001397-nrq4ncdf 693 58 pathway pathway NN cord-001397-nrq4ncdf 693 59 by by IN cord-001397-nrq4ncdf 693 60 Japanese japanese JJ cord-001397-nrq4ncdf 693 61 encephalitis encephalitis RB cord-001397-nrq4ncdf 693 62 virus virus NN cord-001397-nrq4ncdf 693 63 infection infection NN cord-001397-nrq4ncdf 694 1 Japanese japanese JJ cord-001397-nrq4ncdf 694 2 encephalitis encephalitis RB cord-001397-nrq4ncdf 694 3 virus virus NN cord-001397-nrq4ncdf 695 1 NS2B NS2B NNP cord-001397-nrq4ncdf 695 2 - - : cord-001397-nrq4ncdf 695 3 NS3 ns3 RB cord-001397-nrq4ncdf 695 4 protease protease NN cord-001397-nrq4ncdf 695 5 binding bind VBG cord-001397-nrq4ncdf 695 6 to to IN cord-001397-nrq4ncdf 695 7 phage phage NN cord-001397-nrq4ncdf 695 8 - - HYPH cord-001397-nrq4ncdf 695 9 displayed display VBN cord-001397-nrq4ncdf 695 10 human human JJ cord-001397-nrq4ncdf 695 11 brain brain NN cord-001397-nrq4ncdf 695 12 proteins protein NNS cord-001397-nrq4ncdf 695 13 with with IN cord-001397-nrq4ncdf 695 14 the the DT cord-001397-nrq4ncdf 695 15 domain domain NN cord-001397-nrq4ncdf 695 16 of of IN cord-001397-nrq4ncdf 695 17 trypsin trypsin NN cord-001397-nrq4ncdf 695 18 inhibitor inhibitor NN cord-001397-nrq4ncdf 695 19 and and CC cord-001397-nrq4ncdf 695 20 basic basic JJ cord-001397-nrq4ncdf 695 21 region region NN cord-001397-nrq4ncdf 695 22 leucine leucine NN cord-001397-nrq4ncdf 695 23 zipper zipper NNP cord-001397-nrq4ncdf 695 24 Analysis Analysis NNP cord-001397-nrq4ncdf 695 25 of of IN cord-001397-nrq4ncdf 695 26 adaptive adaptive JJ cord-001397-nrq4ncdf 695 27 mutations mutation NNS cord-001397-nrq4ncdf 695 28 in in IN cord-001397-nrq4ncdf 696 1 Kunjin Kunjin NNP cord-001397-nrq4ncdf 696 2 virus virus NN cord-001397-nrq4ncdf 696 3 replicon replicon NNP cord-001397-nrq4ncdf 696 4 RNA RNA NNP cord-001397-nrq4ncdf 696 5 reveals reveal VBZ cord-001397-nrq4ncdf 696 6 a a DT cord-001397-nrq4ncdf 696 7 novel novel JJ cord-001397-nrq4ncdf 696 8 role role NN cord-001397-nrq4ncdf 696 9 for for IN cord-001397-nrq4ncdf 696 10 the the DT cord-001397-nrq4ncdf 696 11 flavivirus flavivirus JJ cord-001397-nrq4ncdf 696 12 non non JJ cord-001397-nrq4ncdf 696 13 - - JJ cord-001397-nrq4ncdf 696 14 structural structural JJ cord-001397-nrq4ncdf 696 15 protein protein NN cord-001397-nrq4ncdf 696 16 NS2A ns2a RBR cord-001397-nrq4ncdf 696 17 in in IN cord-001397-nrq4ncdf 696 18 inhibition inhibition NN cord-001397-nrq4ncdf 696 19 of of IN cord-001397-nrq4ncdf 696 20 beta beta JJ cord-001397-nrq4ncdf 696 21 interferon interferon NN cord-001397-nrq4ncdf 696 22 promoter promoter NN cord-001397-nrq4ncdf 696 23 - - HYPH cord-001397-nrq4ncdf 696 24 driven drive VBN cord-001397-nrq4ncdf 696 25 transcription transcription NN cord-001397-nrq4ncdf 696 26 Inhibition inhibition NN cord-001397-nrq4ncdf 696 27 of of IN cord-001397-nrq4ncdf 696 28 interferon interferon NN cord-001397-nrq4ncdf 696 29 signaling signal VBG cord-001397-nrq4ncdf 696 30 by by IN cord-001397-nrq4ncdf 696 31 the the DT cord-001397-nrq4ncdf 696 32 New New NNP cord-001397-nrq4ncdf 696 33 York York NNP cord-001397-nrq4ncdf 696 34 99 99 CD cord-001397-nrq4ncdf 696 35 strain strain NN cord-001397-nrq4ncdf 696 36 and and CC cord-001397-nrq4ncdf 696 37 Kunjin Kunjin NNP cord-001397-nrq4ncdf 696 38 subtype subtype NN cord-001397-nrq4ncdf 696 39 of of IN cord-001397-nrq4ncdf 696 40 West West NNP cord-001397-nrq4ncdf 696 41 Nile Nile NNP cord-001397-nrq4ncdf 696 42 virus virus NN cord-001397-nrq4ncdf 696 43 involves involve VBZ cord-001397-nrq4ncdf 696 44 blockage blockage NN cord-001397-nrq4ncdf 696 45 of of IN cord-001397-nrq4ncdf 696 46 STAT1 stat1 NN cord-001397-nrq4ncdf 696 47 and and CC cord-001397-nrq4ncdf 696 48 STAT2 STAT2 NNS cord-001397-nrq4ncdf 696 49 activation activation NN cord-001397-nrq4ncdf 696 50 by by IN cord-001397-nrq4ncdf 696 51 nonstructural nonstructural JJ cord-001397-nrq4ncdf 696 52 proteins protein NNS cord-001397-nrq4ncdf 697 1 A a DT cord-001397-nrq4ncdf 697 2 single single JJ cord-001397-nrq4ncdf 697 3 amino amino NN cord-001397-nrq4ncdf 697 4 acid acid NN cord-001397-nrq4ncdf 697 5 substitution substitution NN cord-001397-nrq4ncdf 697 6 in in IN cord-001397-nrq4ncdf 697 7 the the DT cord-001397-nrq4ncdf 697 8 West West NNP cord-001397-nrq4ncdf 697 9 Nile Nile NNP cord-001397-nrq4ncdf 697 10 virus virus NN cord-001397-nrq4ncdf 697 11 non non JJ cord-001397-nrq4ncdf 697 12 - - JJ cord-001397-nrq4ncdf 697 13 structural structural JJ cord-001397-nrq4ncdf 697 14 protein protein NN cord-001397-nrq4ncdf 698 1 NS2A NS2A NNP cord-001397-nrq4ncdf 698 2 disables disable VBZ cord-001397-nrq4ncdf 698 3 its -PRON- PRP$ cord-001397-nrq4ncdf 698 4 ability ability NN cord-001397-nrq4ncdf 698 5 to to TO cord-001397-nrq4ncdf 698 6 inhibit inhibit VB cord-001397-nrq4ncdf 698 7 alpha/ alpha/ NN cord-001397-nrq4ncdf 698 8 beta beta NN cord-001397-nrq4ncdf 698 9 interferon interferon NN cord-001397-nrq4ncdf 698 10 induction induction NN cord-001397-nrq4ncdf 698 11 and and CC cord-001397-nrq4ncdf 698 12 attenuates attenuate VBZ cord-001397-nrq4ncdf 698 13 virus virus NN cord-001397-nrq4ncdf 698 14 virulence virulence NN cord-001397-nrq4ncdf 698 15 in in IN cord-001397-nrq4ncdf 698 16 mice mice NN cord-001397-nrq4ncdf 698 17 Cis Cis NNP cord-001397-nrq4ncdf 698 18 - - HYPH cord-001397-nrq4ncdf 698 19 acting act VBG cord-001397-nrq4ncdf 698 20 RNA RNA NNP cord-001397-nrq4ncdf 698 21 elements element NNS cord-001397-nrq4ncdf 698 22 in in IN cord-001397-nrq4ncdf 698 23 human human JJ cord-001397-nrq4ncdf 698 24 and and CC cord-001397-nrq4ncdf 698 25 animal animal NN cord-001397-nrq4ncdf 698 26 plus plus JJ cord-001397-nrq4ncdf 698 27 - - HYPH cord-001397-nrq4ncdf 698 28 strand strand NN cord-001397-nrq4ncdf 698 29 RNA RNA NNP cord-001397-nrq4ncdf 698 30 viruses virus NNS cord-001397-nrq4ncdf 698 31 Structural structural JJ cord-001397-nrq4ncdf 698 32 and and CC cord-001397-nrq4ncdf 698 33 functional functional JJ cord-001397-nrq4ncdf 698 34 studies study NNS cord-001397-nrq4ncdf 698 35 of of IN cord-001397-nrq4ncdf 698 36 the the DT cord-001397-nrq4ncdf 698 37 promoter promoter NN cord-001397-nrq4ncdf 698 38 element element NN cord-001397-nrq4ncdf 698 39 for for IN cord-001397-nrq4ncdf 698 40 dengue dengue NN cord-001397-nrq4ncdf 698 41 virus virus NN cord-001397-nrq4ncdf 698 42 RNA RNA NNP cord-001397-nrq4ncdf 698 43 replication replication NN cord-001397-nrq4ncdf 698 44 Coxsackievirus Coxsackievirus NNP cord-001397-nrq4ncdf 699 1 B-3 B-3 NNP cord-001397-nrq4ncdf 699 2 myocarditis myocarditis NN cord-001397-nrq4ncdf 699 3 Acute acute JJ cord-001397-nrq4ncdf 699 4 and and CC cord-001397-nrq4ncdf 699 5 chronic chronic JJ cord-001397-nrq4ncdf 699 6 forms form NNS cord-001397-nrq4ncdf 699 7 of of IN cord-001397-nrq4ncdf 699 8 the the DT cord-001397-nrq4ncdf 699 9 disease disease NN cord-001397-nrq4ncdf 699 10 caused cause VBN cord-001397-nrq4ncdf 699 11 by by IN cord-001397-nrq4ncdf 699 12 different different JJ cord-001397-nrq4ncdf 699 13 immunopathogenic immunopathogenic NN cord-001397-nrq4ncdf 699 14 mechanisms mechanism NNS cord-001397-nrq4ncdf 699 15 Folding folding NN cord-001397-nrq4ncdf 699 16 and and CC cord-001397-nrq4ncdf 699 17 dimerization dimerization NN cord-001397-nrq4ncdf 699 18 of of IN cord-001397-nrq4ncdf 699 19 tick tick NN cord-001397-nrq4ncdf 699 20 - - HYPH cord-001397-nrq4ncdf 699 21 borne bear VBN cord-001397-nrq4ncdf 699 22 encephalitis encephalitis JJ cord-001397-nrq4ncdf 699 23 virus virus NN cord-001397-nrq4ncdf 699 24 envelope envelope NN cord-001397-nrq4ncdf 699 25 proteins protein NNS cord-001397-nrq4ncdf 699 26 prM prm JJ cord-001397-nrq4ncdf 699 27 and and CC cord-001397-nrq4ncdf 699 28 E e NN cord-001397-nrq4ncdf 699 29 in in IN cord-001397-nrq4ncdf 699 30 the the DT cord-001397-nrq4ncdf 699 31 endoplasmic endoplasmic NN cord-001397-nrq4ncdf 699 32 reticulum reticulum NN cord-001397-nrq4ncdf 699 33 Subcellular Subcellular NNP cord-001397-nrq4ncdf 699 34 localization localization NN cord-001397-nrq4ncdf 699 35 and and CC cord-001397-nrq4ncdf 699 36 some some DT cord-001397-nrq4ncdf 699 37 biochemical biochemical JJ cord-001397-nrq4ncdf 699 38 properties property NNS cord-001397-nrq4ncdf 699 39 of of IN cord-001397-nrq4ncdf 699 40 the the DT cord-001397-nrq4ncdf 699 41 flavivirus flavivirus JJ cord-001397-nrq4ncdf 699 42 Kunjin Kunjin NNP cord-001397-nrq4ncdf 699 43 non non JJ cord-001397-nrq4ncdf 699 44 - - JJ cord-001397-nrq4ncdf 699 45 structural structural JJ cord-001397-nrq4ncdf 699 46 proteins protein NNS cord-001397-nrq4ncdf 700 1 NS2A ns2a RB cord-001397-nrq4ncdf 701 1 and and CC cord-001397-nrq4ncdf 701 2 NS4A ns4a NN cord-001397-nrq4ncdf 702 1 The the DT cord-001397-nrq4ncdf 702 2 Japanese japanese JJ cord-001397-nrq4ncdf 702 3 encephalitis encephalitis RB cord-001397-nrq4ncdf 702 4 serological serological JJ cord-001397-nrq4ncdf 702 5 group group NN cord-001397-nrq4ncdf 702 6 of of IN cord-001397-nrq4ncdf 702 7 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 702 8 : : : cord-001397-nrq4ncdf 702 9 a a DT cord-001397-nrq4ncdf 702 10 brief brief JJ cord-001397-nrq4ncdf 702 11 introduction introduction NN cord-001397-nrq4ncdf 702 12 to to IN cord-001397-nrq4ncdf 702 13 the the DT cord-001397-nrq4ncdf 702 14 group group NN cord-001397-nrq4ncdf 702 15 . . . cord-001397-nrq4ncdf 703 1 Japanese Japanese NNP cord-001397-nrq4ncdf 703 2 Encephalitis Encephalitis NNP cord-001397-nrq4ncdf 703 3 and and CC cord-001397-nrq4ncdf 703 4 West West NNP cord-001397-nrq4ncdf 703 5 Nile Nile NNP cord-001397-nrq4ncdf 703 6 Viruses Viruses NNPS cord-001397-nrq4ncdf 703 7 Emerging emerge VBG cord-001397-nrq4ncdf 703 8 flaviviruses flaviviruse VBZ cord-001397-nrq4ncdf 703 9 : : : cord-001397-nrq4ncdf 703 10 the the DT cord-001397-nrq4ncdf 703 11 spread spread NN cord-001397-nrq4ncdf 703 12 and and CC cord-001397-nrq4ncdf 703 13 resurgence resurgence NN cord-001397-nrq4ncdf 703 14 of of IN cord-001397-nrq4ncdf 703 15 Japanese japanese JJ cord-001397-nrq4ncdf 703 16 encephalitis encephalitis RB cord-001397-nrq4ncdf 703 17 , , , cord-001397-nrq4ncdf 703 18 West West NNP cord-001397-nrq4ncdf 703 19 Nile Nile NNP cord-001397-nrq4ncdf 703 20 and and CC cord-001397-nrq4ncdf 703 21 dengue dengue NN cord-001397-nrq4ncdf 703 22 viruses virus NNS cord-001397-nrq4ncdf 703 23 West West NNP cord-001397-nrq4ncdf 703 24 Nile Nile NNP cord-001397-nrq4ncdf 703 25 virus virus NN cord-001397-nrq4ncdf 703 26 infection infection NN cord-001397-nrq4ncdf 703 27 and and CC cord-001397-nrq4ncdf 703 28 its -PRON- PRP$ cord-001397-nrq4ncdf 703 29 neurological neurological JJ cord-001397-nrq4ncdf 703 30 manifestations manifestation NNS cord-001397-nrq4ncdf 703 31 Powassan Powassan NNP cord-001397-nrq4ncdf 703 32 virus virus NN cord-001397-nrq4ncdf 703 33 in in IN cord-001397-nrq4ncdf 703 34 Ixodes Ixodes NNP cord-001397-nrq4ncdf 703 35 cookei cookei NNP cord-001397-nrq4ncdf 703 36 and and CC cord-001397-nrq4ncdf 703 37 Mustelidae Mustelidae NNP cord-001397-nrq4ncdf 703 38 in in IN cord-001397-nrq4ncdf 703 39 New New NNP cord-001397-nrq4ncdf 703 40 England England NNP cord-001397-nrq4ncdf 703 41 Crystal Crystal NNP cord-001397-nrq4ncdf 703 42 structure structure NN cord-001397-nrq4ncdf 703 43 of of IN cord-001397-nrq4ncdf 703 44 the the DT cord-001397-nrq4ncdf 703 45 RNA RNA NNP cord-001397-nrq4ncdf 703 46 polymerase polymerase NN cord-001397-nrq4ncdf 703 47 domain domain NN cord-001397-nrq4ncdf 703 48 of of IN cord-001397-nrq4ncdf 703 49 the the DT cord-001397-nrq4ncdf 703 50 West West NNP cord-001397-nrq4ncdf 703 51 Nile Nile NNP cord-001397-nrq4ncdf 703 52 virus virus NN cord-001397-nrq4ncdf 703 53 non non JJ cord-001397-nrq4ncdf 703 54 - - JJ cord-001397-nrq4ncdf 703 55 structural structural JJ cord-001397-nrq4ncdf 703 56 protein protein NN cord-001397-nrq4ncdf 703 57 5 5 CD cord-001397-nrq4ncdf 703 58 Steps Steps NNPS cord-001397-nrq4ncdf 703 59 of of IN cord-001397-nrq4ncdf 703 60 the the DT cord-001397-nrq4ncdf 703 61 tick tick NN cord-001397-nrq4ncdf 703 62 - - HYPH cord-001397-nrq4ncdf 703 63 borne bear VBN cord-001397-nrq4ncdf 703 64 encephalitis encephalitis JJ cord-001397-nrq4ncdf 703 65 virus virus NN cord-001397-nrq4ncdf 703 66 replication replication NN cord-001397-nrq4ncdf 703 67 cycle cycle NN cord-001397-nrq4ncdf 703 68 that that WDT cord-001397-nrq4ncdf 703 69 affect affect VBP cord-001397-nrq4ncdf 703 70 neuropathogenesis neuropathogenesis NN cord-001397-nrq4ncdf 703 71 Spontaneous spontaneous JJ cord-001397-nrq4ncdf 703 72 and and CC cord-001397-nrq4ncdf 703 73 engineered engineered JJ cord-001397-nrq4ncdf 703 74 deletions deletion NNS cord-001397-nrq4ncdf 703 75 in in IN cord-001397-nrq4ncdf 703 76 the the DT cord-001397-nrq4ncdf 703 77 3 3 CD cord-001397-nrq4ncdf 703 78 0 0 CD cord-001397-nrq4ncdf 703 79 noncoding noncoding JJ cord-001397-nrq4ncdf 703 80 region region NN cord-001397-nrq4ncdf 703 81 of of IN cord-001397-nrq4ncdf 703 82 tick tick NN cord-001397-nrq4ncdf 703 83 - - HYPH cord-001397-nrq4ncdf 703 84 borne bear VBN cord-001397-nrq4ncdf 703 85 encephalitis encephalitis JJ cord-001397-nrq4ncdf 703 86 virus virus NN cord-001397-nrq4ncdf 703 87 : : : cord-001397-nrq4ncdf 703 88 construction construction NN cord-001397-nrq4ncdf 703 89 of of IN cord-001397-nrq4ncdf 703 90 highly highly RB cord-001397-nrq4ncdf 703 91 attenuated attenuated JJ cord-001397-nrq4ncdf 703 92 mutants mutant NNS cord-001397-nrq4ncdf 703 93 of of IN cord-001397-nrq4ncdf 703 94 a a DT cord-001397-nrq4ncdf 703 95 flavivirus flavivirus JJ cord-001397-nrq4ncdf 703 96 Tick tick NN cord-001397-nrq4ncdf 703 97 - - HYPH cord-001397-nrq4ncdf 703 98 borne bear VBN cord-001397-nrq4ncdf 703 99 encephalitis encephalitis JJ cord-001397-nrq4ncdf 703 100 virus virus NN cord-001397-nrq4ncdf 703 101 -a -a HYPH cord-001397-nrq4ncdf 703 102 review review NN cord-001397-nrq4ncdf 703 103 of of IN cord-001397-nrq4ncdf 703 104 an an DT cord-001397-nrq4ncdf 703 105 emerging emerge VBG cord-001397-nrq4ncdf 703 106 zoonosis zoonosis NN cord-001397-nrq4ncdf 703 107 0 0 CD cord-001397-nrq4ncdf 703 108 -and -and CD cord-001397-nrq4ncdf 703 109 3 3 CD cord-001397-nrq4ncdf 703 110 0 0 CD cord-001397-nrq4ncdf 703 111 -noncoding -noncoding NN cord-001397-nrq4ncdf 703 112 regions region NNS cord-001397-nrq4ncdf 703 113 in in IN cord-001397-nrq4ncdf 703 114 flavivirus flavivirus NNP cord-001397-nrq4ncdf 703 115 RNA RNA NNP cord-001397-nrq4ncdf 703 116 Viruses virus NNS cord-001397-nrq4ncdf 703 117 infecting infect VBG cord-001397-nrq4ncdf 703 118 reptiles reptile NNS cord-001397-nrq4ncdf 703 119 Dengue Dengue NNP cord-001397-nrq4ncdf 703 120 virus virus NN cord-001397-nrq4ncdf 703 121 pathogenesis pathogenesis NN cord-001397-nrq4ncdf 703 122 : : : cord-001397-nrq4ncdf 703 123 an an DT cord-001397-nrq4ncdf 703 124 integrated integrated JJ cord-001397-nrq4ncdf 703 125 view view NN cord-001397-nrq4ncdf 704 1 Ivermectin Ivermectin NNP cord-001397-nrq4ncdf 704 2 is be VBZ cord-001397-nrq4ncdf 704 3 a a DT cord-001397-nrq4ncdf 704 4 potent potent JJ cord-001397-nrq4ncdf 704 5 inhibitor inhibitor NN cord-001397-nrq4ncdf 704 6 of of IN cord-001397-nrq4ncdf 704 7 flavivirus flavivirus JJ cord-001397-nrq4ncdf 704 8 replication replication NN cord-001397-nrq4ncdf 704 9 specifically specifically RB cord-001397-nrq4ncdf 704 10 targeting target VBG cord-001397-nrq4ncdf 704 11 NS3 ns3 RB cord-001397-nrq4ncdf 704 12 helicase helicase NN cord-001397-nrq4ncdf 704 13 activity activity NN cord-001397-nrq4ncdf 704 14 : : : cord-001397-nrq4ncdf 704 15 new new JJ cord-001397-nrq4ncdf 704 16 prospects prospect NNS cord-001397-nrq4ncdf 704 17 for for IN cord-001397-nrq4ncdf 704 18 an an DT cord-001397-nrq4ncdf 704 19 old old JJ cord-001397-nrq4ncdf 704 20 drug drug NN cord-001397-nrq4ncdf 704 21 Japanese japanese JJ cord-001397-nrq4ncdf 704 22 encephalitis encephalitis RB cord-001397-nrq4ncdf 704 23 virus virus NN cord-001397-nrq4ncdf 704 24 latency latency NN cord-001397-nrq4ncdf 704 25 following follow VBG cord-001397-nrq4ncdf 704 26 congenital congenital JJ cord-001397-nrq4ncdf 704 27 infection infection NN cord-001397-nrq4ncdf 704 28 in in IN cord-001397-nrq4ncdf 704 29 mice mouse NNS cord-001397-nrq4ncdf 704 30 Persistence persistence NN cord-001397-nrq4ncdf 704 31 , , , cord-001397-nrq4ncdf 704 32 latency latency NN cord-001397-nrq4ncdf 704 33 and and CC cord-001397-nrq4ncdf 704 34 reactivation reactivation NN cord-001397-nrq4ncdf 704 35 of of IN cord-001397-nrq4ncdf 704 36 Japanese japanese JJ cord-001397-nrq4ncdf 704 37 encephalitis encephalitis RB cord-001397-nrq4ncdf 704 38 virus virus NN cord-001397-nrq4ncdf 704 39 infection infection NN cord-001397-nrq4ncdf 704 40 in in IN cord-001397-nrq4ncdf 704 41 mice mouse NNS cord-001397-nrq4ncdf 705 1 Dengue dengue NN cord-001397-nrq4ncdf 705 2 virus virus NN cord-001397-nrq4ncdf 705 3 NS5 NS5 NNP cord-001397-nrq4ncdf 705 4 inhibits inhibit VBZ cord-001397-nrq4ncdf 705 5 interferon interferon NN cord-001397-nrq4ncdf 705 6 - - HYPH cord-001397-nrq4ncdf 705 7 alpha alpha NN cord-001397-nrq4ncdf 705 8 signaling signaling NN cord-001397-nrq4ncdf 705 9 by by IN cord-001397-nrq4ncdf 705 10 blocking block VBG cord-001397-nrq4ncdf 705 11 signal signal NN cord-001397-nrq4ncdf 705 12 transducer transducer NN cord-001397-nrq4ncdf 705 13 and and CC cord-001397-nrq4ncdf 705 14 activator activator NN cord-001397-nrq4ncdf 705 15 of of IN cord-001397-nrq4ncdf 705 16 transcription transcription NN cord-001397-nrq4ncdf 705 17 2 2 CD cord-001397-nrq4ncdf 705 18 phosphorylation phosphorylation NN cord-001397-nrq4ncdf 705 19 Infection infection NN cord-001397-nrq4ncdf 705 20 , , , cord-001397-nrq4ncdf 705 21 dissemination dissemination NN cord-001397-nrq4ncdf 705 22 , , , cord-001397-nrq4ncdf 705 23 and and CC cord-001397-nrq4ncdf 705 24 transmission transmission NN cord-001397-nrq4ncdf 705 25 of of IN cord-001397-nrq4ncdf 705 26 a a DT cord-001397-nrq4ncdf 705 27 West West NNP cord-001397-nrq4ncdf 705 28 Nile Nile NNP cord-001397-nrq4ncdf 705 29 virus virus NN cord-001397-nrq4ncdf 705 30 green green JJ cord-001397-nrq4ncdf 705 31 fluorescent fluorescent NN cord-001397-nrq4ncdf 705 32 protein protein NN cord-001397-nrq4ncdf 705 33 infectious infectious JJ cord-001397-nrq4ncdf 705 34 clone clone NN cord-001397-nrq4ncdf 705 35 by by IN cord-001397-nrq4ncdf 705 36 Culex Culex NNP cord-001397-nrq4ncdf 705 37 pipiens pipiens NNPS cord-001397-nrq4ncdf 705 38 quinquefasciatus quinquefasciatus NN cord-001397-nrq4ncdf 705 39 mosquitoes mosquito NNS cord-001397-nrq4ncdf 705 40 Bird Bird NNP cord-001397-nrq4ncdf 705 41 community community NN cord-001397-nrq4ncdf 705 42 composition composition NN cord-001397-nrq4ncdf 705 43 linked link VBN cord-001397-nrq4ncdf 705 44 to to IN cord-001397-nrq4ncdf 705 45 human human JJ cord-001397-nrq4ncdf 705 46 West West NNP cord-001397-nrq4ncdf 705 47 Nile Nile NNP cord-001397-nrq4ncdf 705 48 virus virus NN cord-001397-nrq4ncdf 705 49 cases case NNS cord-001397-nrq4ncdf 705 50 along along IN cord-001397-nrq4ncdf 705 51 the the DT cord-001397-nrq4ncdf 705 52 Colorado Colorado NNP cord-001397-nrq4ncdf 705 53 Front Front NNP cord-001397-nrq4ncdf 705 54 Range Range NNP cord-001397-nrq4ncdf 705 55 Flavivirus Flavivirus NNP cord-001397-nrq4ncdf 705 56 NS4A NS4A NNP cord-001397-nrq4ncdf 705 57 - - HYPH cord-001397-nrq4ncdf 705 58 induced induce VBN cord-001397-nrq4ncdf 705 59 autophagy autophagy NN cord-001397-nrq4ncdf 705 60 protects protect VBZ cord-001397-nrq4ncdf 705 61 cells cell NNS cord-001397-nrq4ncdf 705 62 against against IN cord-001397-nrq4ncdf 705 63 death death NN cord-001397-nrq4ncdf 705 64 and and CC cord-001397-nrq4ncdf 705 65 enhances enhance VBZ cord-001397-nrq4ncdf 705 66 virus virus NN cord-001397-nrq4ncdf 705 67 replication replication NN cord-001397-nrq4ncdf 706 1 The the DT cord-001397-nrq4ncdf 706 2 molecular molecular JJ cord-001397-nrq4ncdf 706 3 basis basis NN cord-001397-nrq4ncdf 706 4 of of IN cord-001397-nrq4ncdf 706 5 virulence virulence NN cord-001397-nrq4ncdf 706 6 of of IN cord-001397-nrq4ncdf 706 7 the the DT cord-001397-nrq4ncdf 706 8 encephalitogenic encephalitogenic NNP cord-001397-nrq4ncdf 706 9 flaviviruses flaviviruses NNP cord-001397-nrq4ncdf 706 10 Differential Differential NNP cord-001397-nrq4ncdf 706 11 salivary salivary NNP cord-001397-nrq4ncdf 706 12 gland gland NN cord-001397-nrq4ncdf 706 13 transcript transcript NN cord-001397-nrq4ncdf 706 14 expression expression NN cord-001397-nrq4ncdf 706 15 profile profile NN cord-001397-nrq4ncdf 706 16 in in IN cord-001397-nrq4ncdf 706 17 Ixodes Ixodes NNP cord-001397-nrq4ncdf 706 18 scapularis scapularis NN cord-001397-nrq4ncdf 706 19 nymphs nymph NNS cord-001397-nrq4ncdf 706 20 upon upon IN cord-001397-nrq4ncdf 706 21 feeding feed VBG cord-001397-nrq4ncdf 706 22 or or CC cord-001397-nrq4ncdf 706 23 flavivirus flavivirus JJ cord-001397-nrq4ncdf 706 24 infection infection NN cord-001397-nrq4ncdf 706 25 NS1 NS1 NNP cord-001397-nrq4ncdf 706 26 0 0 CD cord-001397-nrq4ncdf 706 27 of of IN cord-001397-nrq4ncdf 706 28 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 706 29 in in IN cord-001397-nrq4ncdf 706 30 the the DT cord-001397-nrq4ncdf 706 31 Japanese japanese JJ cord-001397-nrq4ncdf 706 32 encephalitis encephalitis NN cord-001397-nrq4ncdf 706 33 virus virus NN cord-001397-nrq4ncdf 706 34 serogroup serogroup NN cord-001397-nrq4ncdf 706 35 is be VBZ cord-001397-nrq4ncdf 706 36 a a DT cord-001397-nrq4ncdf 706 37 product product NN cord-001397-nrq4ncdf 706 38 of of IN cord-001397-nrq4ncdf 706 39 ribosomal ribosomal JJ cord-001397-nrq4ncdf 706 40 frame frame NN cord-001397-nrq4ncdf 706 41 shifting shift VBG cord-001397-nrq4ncdf 706 42 and and CC cord-001397-nrq4ncdf 706 43 plays play VBZ cord-001397-nrq4ncdf 706 44 a a DT cord-001397-nrq4ncdf 706 45 role role NN cord-001397-nrq4ncdf 706 46 in in IN cord-001397-nrq4ncdf 706 47 viral viral JJ cord-001397-nrq4ncdf 706 48 neuroinvasiveness neuroinvasiveness JJ cord-001397-nrq4ncdf 706 49 West West NNP cord-001397-nrq4ncdf 706 50 Nile Nile NNP cord-001397-nrq4ncdf 706 51 virus virus NN cord-001397-nrq4ncdf 706 52 NS2A NS2A JJR cord-001397-nrq4ncdf 706 53 protein protein NN cord-001397-nrq4ncdf 706 54 facilitates facilitate VBZ cord-001397-nrq4ncdf 706 55 virus virus NN cord-001397-nrq4ncdf 706 56 - - HYPH cord-001397-nrq4ncdf 706 57 induced induce VBN cord-001397-nrq4ncdf 706 58 apoptosis apoptosis NN cord-001397-nrq4ncdf 706 59 independently independently RB cord-001397-nrq4ncdf 706 60 of of IN cord-001397-nrq4ncdf 706 61 interferon interferon NN cord-001397-nrq4ncdf 706 62 response response NN cord-001397-nrq4ncdf 706 63 Persistent persistent JJ cord-001397-nrq4ncdf 706 64 hantavirus hantavirus NN cord-001397-nrq4ncdf 706 65 infections infection NNS cord-001397-nrq4ncdf 706 66 : : : cord-001397-nrq4ncdf 706 67 characteristics characteristic NNS cord-001397-nrq4ncdf 706 68 and and CC cord-001397-nrq4ncdf 706 69 mechanisms mechanism NNS cord-001397-nrq4ncdf 706 70 Subcellular Subcellular NNP cord-001397-nrq4ncdf 706 71 localization localization NN cord-001397-nrq4ncdf 706 72 and and CC cord-001397-nrq4ncdf 706 73 membrane membrane NN cord-001397-nrq4ncdf 706 74 topology topology NN cord-001397-nrq4ncdf 706 75 of of IN cord-001397-nrq4ncdf 706 76 the the DT cord-001397-nrq4ncdf 706 77 Dengue Dengue NNP cord-001397-nrq4ncdf 706 78 virus virus NN cord-001397-nrq4ncdf 706 79 type type NN cord-001397-nrq4ncdf 706 80 2 2 CD cord-001397-nrq4ncdf 706 81 Non non JJ cord-001397-nrq4ncdf 706 82 - - JJ cord-001397-nrq4ncdf 706 83 structural structural JJ cord-001397-nrq4ncdf 706 84 protein protein NN cord-001397-nrq4ncdf 706 85 4B 4b CD cord-001397-nrq4ncdf 707 1 The the DT cord-001397-nrq4ncdf 707 2 non non JJ cord-001397-nrq4ncdf 707 3 - - JJ cord-001397-nrq4ncdf 707 4 structural structural JJ cord-001397-nrq4ncdf 707 5 protein protein NN cord-001397-nrq4ncdf 707 6 4A 4a CD cord-001397-nrq4ncdf 707 7 of of IN cord-001397-nrq4ncdf 707 8 dengue dengue NN cord-001397-nrq4ncdf 707 9 virus virus NN cord-001397-nrq4ncdf 707 10 is be VBZ cord-001397-nrq4ncdf 707 11 an an DT cord-001397-nrq4ncdf 707 12 integral integral JJ cord-001397-nrq4ncdf 707 13 membrane membrane NN cord-001397-nrq4ncdf 707 14 protein protein NN cord-001397-nrq4ncdf 707 15 inducing induce VBG cord-001397-nrq4ncdf 707 16 membrane membrane NN cord-001397-nrq4ncdf 707 17 alterations alteration NNS cord-001397-nrq4ncdf 707 18 in in IN cord-001397-nrq4ncdf 707 19 a a DT cord-001397-nrq4ncdf 707 20 2K 2k RB cord-001397-nrq4ncdf 707 21 - - HYPH cord-001397-nrq4ncdf 707 22 regulated regulate VBN cord-001397-nrq4ncdf 707 23 manner manner NN cord-001397-nrq4ncdf 707 24 Spatial spatial JJ cord-001397-nrq4ncdf 707 25 and and CC cord-001397-nrq4ncdf 707 26 temporal temporal JJ cord-001397-nrq4ncdf 707 27 organization organization NN cord-001397-nrq4ncdf 707 28 of of IN cord-001397-nrq4ncdf 707 29 tick tick VB cord-001397-nrq4ncdf 707 30 - - HYPH cord-001397-nrq4ncdf 707 31 borne bear VBN cord-001397-nrq4ncdf 707 32 encephalitis encephalitis RB cord-001397-nrq4ncdf 707 33 flavivirus flavivirus NNP cord-001397-nrq4ncdf 707 34 replicated replicate VBD cord-001397-nrq4ncdf 707 35 RNA RNA NNP cord-001397-nrq4ncdf 707 36 in in IN cord-001397-nrq4ncdf 707 37 living living NN cord-001397-nrq4ncdf 707 38 cells cell NNS cord-001397-nrq4ncdf 707 39 Tick tick VB cord-001397-nrq4ncdf 707 40 - - HYPH cord-001397-nrq4ncdf 707 41 borne bear VBN cord-001397-nrq4ncdf 707 42 flavivirus flavivirus JJ cord-001397-nrq4ncdf 707 43 infection infection NN cord-001397-nrq4ncdf 707 44 in in IN cord-001397-nrq4ncdf 707 45 Ixodes Ixodes NNP cord-001397-nrq4ncdf 707 46 scapularis scapularis NN cord-001397-nrq4ncdf 707 47 larvae larva NNS cord-001397-nrq4ncdf 707 48 : : : cord-001397-nrq4ncdf 707 49 development development NN cord-001397-nrq4ncdf 707 50 of of IN cord-001397-nrq4ncdf 707 51 a a DT cord-001397-nrq4ncdf 707 52 novel novel JJ cord-001397-nrq4ncdf 707 53 method method NN cord-001397-nrq4ncdf 707 54 for for IN cord-001397-nrq4ncdf 707 55 synchronous synchronous JJ cord-001397-nrq4ncdf 707 56 viral viral JJ cord-001397-nrq4ncdf 707 57 infection infection NN cord-001397-nrq4ncdf 707 58 of of IN cord-001397-nrq4ncdf 707 59 ticks tick NNS cord-001397-nrq4ncdf 707 60 A a DT cord-001397-nrq4ncdf 707 61 ligand ligand NN cord-001397-nrq4ncdf 707 62 - - HYPH cord-001397-nrq4ncdf 707 63 binding bind VBG cord-001397-nrq4ncdf 707 64 pocket pocket NN cord-001397-nrq4ncdf 707 65 in in IN cord-001397-nrq4ncdf 707 66 the the DT cord-001397-nrq4ncdf 707 67 dengue dengue NN cord-001397-nrq4ncdf 707 68 virus virus NN cord-001397-nrq4ncdf 707 69 envelope envelope NN cord-001397-nrq4ncdf 707 70 glycoprotein glycoprotein NN cord-001397-nrq4ncdf 707 71 Variable variable JJ cord-001397-nrq4ncdf 707 72 surface surface NN cord-001397-nrq4ncdf 707 73 epitopes epitope NNS cord-001397-nrq4ncdf 707 74 in in IN cord-001397-nrq4ncdf 707 75 the the DT cord-001397-nrq4ncdf 707 76 crystal crystal JJ cord-001397-nrq4ncdf 707 77 structure structure NN cord-001397-nrq4ncdf 707 78 of of IN cord-001397-nrq4ncdf 707 79 dengue dengue NN cord-001397-nrq4ncdf 707 80 virus virus NN cord-001397-nrq4ncdf 707 81 type type NN cord-001397-nrq4ncdf 707 82 3 3 CD cord-001397-nrq4ncdf 707 83 envelope envelope NN cord-001397-nrq4ncdf 707 84 glycoprotein glycoprotein NN cord-001397-nrq4ncdf 707 85 Studies study NNS cord-001397-nrq4ncdf 707 86 on on IN cord-001397-nrq4ncdf 707 87 the the DT cord-001397-nrq4ncdf 707 88 occurrence occurrence NN cord-001397-nrq4ncdf 707 89 of of IN cord-001397-nrq4ncdf 707 90 tick tick NN cord-001397-nrq4ncdf 707 91 - - HYPH cord-001397-nrq4ncdf 707 92 borne bear VBN cord-001397-nrq4ncdf 707 93 encephalitis encephalitis RB cord-001397-nrq4ncdf 707 94 in in IN cord-001397-nrq4ncdf 707 95 Hungary Hungary NNP cord-001397-nrq4ncdf 707 96 Single Single NNP cord-001397-nrq4ncdf 707 97 mutation mutation NN cord-001397-nrq4ncdf 707 98 in in IN cord-001397-nrq4ncdf 707 99 the the DT cord-001397-nrq4ncdf 707 100 flavivirus flavivirus NNP cord-001397-nrq4ncdf 707 101 envelope envelope NN cord-001397-nrq4ncdf 707 102 protein protein NN cord-001397-nrq4ncdf 707 103 hinge hinge NN cord-001397-nrq4ncdf 707 104 region region NN cord-001397-nrq4ncdf 707 105 increases increase VBZ cord-001397-nrq4ncdf 707 106 neurovirulence neurovirulence NN cord-001397-nrq4ncdf 707 107 for for IN cord-001397-nrq4ncdf 707 108 mice mouse NNS cord-001397-nrq4ncdf 707 109 and and CC cord-001397-nrq4ncdf 707 110 monkeys monkey NNS cord-001397-nrq4ncdf 707 111 but but CC cord-001397-nrq4ncdf 707 112 decreases decrease VBZ cord-001397-nrq4ncdf 707 113 viscerotropism viscerotropism NN cord-001397-nrq4ncdf 707 114 for for IN cord-001397-nrq4ncdf 707 115 monkeys monkey NNS cord-001397-nrq4ncdf 707 116 : : : cord-001397-nrq4ncdf 707 117 relevance relevance NN cord-001397-nrq4ncdf 707 118 to to IN cord-001397-nrq4ncdf 707 119 development development NN cord-001397-nrq4ncdf 707 120 and and CC cord-001397-nrq4ncdf 707 121 safety safety NN cord-001397-nrq4ncdf 707 122 testing testing NN cord-001397-nrq4ncdf 707 123 of of IN cord-001397-nrq4ncdf 707 124 live live JJ cord-001397-nrq4ncdf 707 125 , , , cord-001397-nrq4ncdf 707 126 attenuated attenuated JJ cord-001397-nrq4ncdf 707 127 vaccines vaccine NNS cord-001397-nrq4ncdf 707 128 Transfusion transfusion NN cord-001397-nrq4ncdf 707 129 - - HYPH cord-001397-nrq4ncdf 707 130 associated associate VBN cord-001397-nrq4ncdf 707 131 transmission transmission NN cord-001397-nrq4ncdf 707 132 of of IN cord-001397-nrq4ncdf 707 133 West West NNP cord-001397-nrq4ncdf 707 134 Nile Nile NNP cord-001397-nrq4ncdf 707 135 virus virus NN cord-001397-nrq4ncdf 707 136 Cell cell NN cord-001397-nrq4ncdf 707 137 death death NN cord-001397-nrq4ncdf 707 138 gene gene NN cord-001397-nrq4ncdf 707 139 expression expression NN cord-001397-nrq4ncdf 707 140 profile profile NN cord-001397-nrq4ncdf 707 141 : : : cord-001397-nrq4ncdf 707 142 role role NN cord-001397-nrq4ncdf 707 143 of of IN cord-001397-nrq4ncdf 707 144 RIPK2 ripk2 XX cord-001397-nrq4ncdf 707 145 in in IN cord-001397-nrq4ncdf 707 146 dengue dengue NN cord-001397-nrq4ncdf 707 147 virus virus NN cord-001397-nrq4ncdf 707 148 - - HYPH cord-001397-nrq4ncdf 707 149 mediated mediate VBN cord-001397-nrq4ncdf 707 150 apoptosis apoptosis NN cord-001397-nrq4ncdf 707 151 Nuclear nuclear JJ cord-001397-nrq4ncdf 707 152 localization localization NN cord-001397-nrq4ncdf 707 153 of of IN cord-001397-nrq4ncdf 707 154 Japanese japanese JJ cord-001397-nrq4ncdf 707 155 encephalitis encephalitis RB cord-001397-nrq4ncdf 707 156 virus virus NN cord-001397-nrq4ncdf 707 157 core core NN cord-001397-nrq4ncdf 707 158 protein protein NN cord-001397-nrq4ncdf 707 159 enhances enhance VBZ cord-001397-nrq4ncdf 707 160 viral viral JJ cord-001397-nrq4ncdf 707 161 replication replication NN cord-001397-nrq4ncdf 707 162 Modeling model VBG cord-001397-nrq4ncdf 707 163 hamsters hamster NNS cord-001397-nrq4ncdf 707 164 for for IN cord-001397-nrq4ncdf 707 165 evaluating evaluate VBG cord-001397-nrq4ncdf 707 166 West West NNP cord-001397-nrq4ncdf 707 167 Nile Nile NNP cord-001397-nrq4ncdf 707 168 virus virus NN cord-001397-nrq4ncdf 707 169 therapies therapy NNS cord-001397-nrq4ncdf 707 170 Role role NN cord-001397-nrq4ncdf 707 171 of of IN cord-001397-nrq4ncdf 707 172 virus virus NN cord-001397-nrq4ncdf 707 173 and and CC cord-001397-nrq4ncdf 707 174 host host NN cord-001397-nrq4ncdf 707 175 variables variable NNS cord-001397-nrq4ncdf 707 176 in in IN cord-001397-nrq4ncdf 707 177 virus virus NN cord-001397-nrq4ncdf 707 178 persistence persistence NN cord-001397-nrq4ncdf 707 179 or or CC cord-001397-nrq4ncdf 707 180 immunopathological immunopathological JJ cord-001397-nrq4ncdf 707 181 disease disease NN cord-001397-nrq4ncdf 707 182 caused cause VBN cord-001397-nrq4ncdf 707 183 by by IN cord-001397-nrq4ncdf 707 184 a a DT cord-001397-nrq4ncdf 707 185 non non JJ cord-001397-nrq4ncdf 707 186 - - JJ cord-001397-nrq4ncdf 707 187 cytolytic cytolytic JJ cord-001397-nrq4ncdf 707 188 virus virus NN cord-001397-nrq4ncdf 707 189 Establishment Establishment NNP cord-001397-nrq4ncdf 707 190 , , , cord-001397-nrq4ncdf 707 191 maintenance maintenance NN cord-001397-nrq4ncdf 707 192 and and CC cord-001397-nrq4ncdf 707 193 description description NN cord-001397-nrq4ncdf 707 194 of of IN cord-001397-nrq4ncdf 707 195 cell cell NN cord-001397-nrq4ncdf 707 196 lines line NNS cord-001397-nrq4ncdf 707 197 from from IN cord-001397-nrq4ncdf 707 198 the the DT cord-001397-nrq4ncdf 707 199 tick tick NN cord-001397-nrq4ncdf 707 200 Ixodes Ixodes NNP cord-001397-nrq4ncdf 707 201 scapularis scapularis VBP cord-001397-nrq4ncdf 707 202 Inhibition inhibition NN cord-001397-nrq4ncdf 707 203 of of IN cord-001397-nrq4ncdf 707 204 interferon interferon NN cord-001397-nrq4ncdf 707 205 signaling signal VBG cord-001397-nrq4ncdf 707 206 by by IN cord-001397-nrq4ncdf 707 207 dengue dengue NN cord-001397-nrq4ncdf 707 208 virus virus NN cord-001397-nrq4ncdf 707 209 Inhibition inhibition NN cord-001397-nrq4ncdf 707 210 of of IN cord-001397-nrq4ncdf 707 211 alpha/ alpha/ CD cord-001397-nrq4ncdf 707 212 beta beta NN cord-001397-nrq4ncdf 708 1 interferon interferon NN cord-001397-nrq4ncdf 708 2 signaling signal VBG cord-001397-nrq4ncdf 708 3 by by IN cord-001397-nrq4ncdf 708 4 the the DT cord-001397-nrq4ncdf 708 5 NS4B NS4B NNP cord-001397-nrq4ncdf 708 6 protein protein NN cord-001397-nrq4ncdf 708 7 of of IN cord-001397-nrq4ncdf 708 8 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 708 9 Highly highly RB cord-001397-nrq4ncdf 708 10 sensitive sensitive JJ cord-001397-nrq4ncdf 708 11 detection detection NN cord-001397-nrq4ncdf 708 12 of of IN cord-001397-nrq4ncdf 708 13 dengue dengue NN cord-001397-nrq4ncdf 708 14 virus virus NN cord-001397-nrq4ncdf 708 15 nucleic nucleic VBN cord-001397-nrq4ncdf 708 16 acid acid NN cord-001397-nrq4ncdf 708 17 in in IN cord-001397-nrq4ncdf 708 18 samples sample NNS cord-001397-nrq4ncdf 708 19 from from IN cord-001397-nrq4ncdf 708 20 clinically clinically RB cord-001397-nrq4ncdf 708 21 ill ill JJ cord-001397-nrq4ncdf 708 22 patients patient NNS cord-001397-nrq4ncdf 709 1 Persistent persistent JJ cord-001397-nrq4ncdf 709 2 infection infection NN cord-001397-nrq4ncdf 709 3 with with IN cord-001397-nrq4ncdf 709 4 West West NNP cord-001397-nrq4ncdf 709 5 Nile Nile NNP cord-001397-nrq4ncdf 709 6 virus virus NN cord-001397-nrq4ncdf 709 7 years year NNS cord-001397-nrq4ncdf 709 8 after after IN cord-001397-nrq4ncdf 709 9 initial initial JJ cord-001397-nrq4ncdf 709 10 infection infection NN cord-001397-nrq4ncdf 709 11 Persistent Persistent NNP cord-001397-nrq4ncdf 709 12 West West NNP cord-001397-nrq4ncdf 709 13 Nile Nile NNP cord-001397-nrq4ncdf 709 14 virus virus NN cord-001397-nrq4ncdf 709 15 infection infection NN cord-001397-nrq4ncdf 709 16 in in IN cord-001397-nrq4ncdf 709 17 the the DT cord-001397-nrq4ncdf 709 18 house house NN cord-001397-nrq4ncdf 709 19 sparrow sparrow NN cord-001397-nrq4ncdf 709 20 Nuclear nuclear JJ cord-001397-nrq4ncdf 709 21 localization localization NN cord-001397-nrq4ncdf 709 22 of of IN cord-001397-nrq4ncdf 709 23 dengue dengue NN cord-001397-nrq4ncdf 709 24 virus virus NN cord-001397-nrq4ncdf 709 25 capsid capsid NN cord-001397-nrq4ncdf 709 26 protein protein NN cord-001397-nrq4ncdf 709 27 is be VBZ cord-001397-nrq4ncdf 709 28 required require VBN cord-001397-nrq4ncdf 709 29 for for IN cord-001397-nrq4ncdf 709 30 DAXX DAXX NNP cord-001397-nrq4ncdf 709 31 interaction interaction NN cord-001397-nrq4ncdf 709 32 and and CC cord-001397-nrq4ncdf 709 33 apoptosis apoptosis NN cord-001397-nrq4ncdf 709 34 The the DT cord-001397-nrq4ncdf 709 35 role role NN cord-001397-nrq4ncdf 709 36 of of IN cord-001397-nrq4ncdf 709 37 dendritic dendritic JJ cord-001397-nrq4ncdf 709 38 cells cell NNS cord-001397-nrq4ncdf 709 39 in in IN cord-001397-nrq4ncdf 709 40 viral viral JJ cord-001397-nrq4ncdf 709 41 persistence persistence NN cord-001397-nrq4ncdf 709 42 Molecular molecular JJ cord-001397-nrq4ncdf 709 43 differences difference NNS cord-001397-nrq4ncdf 709 44 between between IN cord-001397-nrq4ncdf 709 45 wild wild JJ cord-001397-nrq4ncdf 709 46 - - HYPH cord-001397-nrq4ncdf 709 47 type type NN cord-001397-nrq4ncdf 709 48 Japanese japanese JJ cord-001397-nrq4ncdf 709 49 encephalitis encephalitis RB cord-001397-nrq4ncdf 709 50 virus virus NN cord-001397-nrq4ncdf 709 51 strains strain NNS cord-001397-nrq4ncdf 709 52 of of IN cord-001397-nrq4ncdf 709 53 high high JJ cord-001397-nrq4ncdf 709 54 and and CC cord-001397-nrq4ncdf 709 55 low low JJ cord-001397-nrq4ncdf 709 56 mouse mouse NN cord-001397-nrq4ncdf 709 57 neuroinvasiveness neuroinvasiveness NN cord-001397-nrq4ncdf 710 1 The the DT cord-001397-nrq4ncdf 710 2 replication replication NN cord-001397-nrq4ncdf 710 3 and and CC cord-001397-nrq4ncdf 710 4 eclipse eclipse NN cord-001397-nrq4ncdf 710 5 - - HYPH cord-001397-nrq4ncdf 710 6 phase phase NN cord-001397-nrq4ncdf 710 7 of of IN cord-001397-nrq4ncdf 710 8 the the DT cord-001397-nrq4ncdf 710 9 tick tick NN cord-001397-nrq4ncdf 710 10 - - HYPH cord-001397-nrq4ncdf 710 11 borne bear VBN cord-001397-nrq4ncdf 710 12 encephalitis encephalitis JJ cord-001397-nrq4ncdf 710 13 virus virus NN cord-001397-nrq4ncdf 710 14 in in IN cord-001397-nrq4ncdf 710 15 Dermacentor Dermacentor NNP cord-001397-nrq4ncdf 710 16 reticulatus reticulatus NN cord-001397-nrq4ncdf 710 17 Dynamics dynamic NNS cord-001397-nrq4ncdf 710 18 of of IN cord-001397-nrq4ncdf 710 19 infection infection NN cord-001397-nrq4ncdf 710 20 in in IN cord-001397-nrq4ncdf 710 21 tick tick NN cord-001397-nrq4ncdf 710 22 vectors vector NNS cord-001397-nrq4ncdf 710 23 and and CC cord-001397-nrq4ncdf 710 24 at at IN cord-001397-nrq4ncdf 710 25 the the DT cord-001397-nrq4ncdf 710 26 tick tick NN cord-001397-nrq4ncdf 710 27 - - HYPH cord-001397-nrq4ncdf 710 28 host host NN cord-001397-nrq4ncdf 710 29 interface interface NN cord-001397-nrq4ncdf 710 30 Crystal Crystal NNP cord-001397-nrq4ncdf 710 31 structure structure NN cord-001397-nrq4ncdf 710 32 of of IN cord-001397-nrq4ncdf 710 33 the the DT cord-001397-nrq4ncdf 710 34 West West NNP cord-001397-nrq4ncdf 710 35 Nile Nile NNP cord-001397-nrq4ncdf 710 36 virus virus NN cord-001397-nrq4ncdf 710 37 envelope envelope NN cord-001397-nrq4ncdf 710 38 glycoprotein glycoprotein VBG cord-001397-nrq4ncdf 710 39 A a DT cord-001397-nrq4ncdf 710 40 three three CD cord-001397-nrq4ncdf 710 41 - - HYPH cord-001397-nrq4ncdf 710 42 dimensional dimensional JJ cord-001397-nrq4ncdf 710 43 comparison comparison NN cord-001397-nrq4ncdf 710 44 of of IN cord-001397-nrq4ncdf 710 45 tick tick NN cord-001397-nrq4ncdf 710 46 - - HYPH cord-001397-nrq4ncdf 710 47 borne bear VBN cord-001397-nrq4ncdf 710 48 flavivirus flavivirus JJ cord-001397-nrq4ncdf 710 49 infection infection NN cord-001397-nrq4ncdf 710 50 in in IN cord-001397-nrq4ncdf 710 51 mammalian mammalian JJ cord-001397-nrq4ncdf 710 52 and and CC cord-001397-nrq4ncdf 710 53 tick tick VB cord-001397-nrq4ncdf 710 54 cell cell NN cord-001397-nrq4ncdf 710 55 lines line NNS cord-001397-nrq4ncdf 710 56 Jab1 Jab1 NNP cord-001397-nrq4ncdf 710 57 mediates mediate VBZ cord-001397-nrq4ncdf 710 58 cytoplasmic cytoplasmic JJ cord-001397-nrq4ncdf 710 59 localization localization NN cord-001397-nrq4ncdf 710 60 and and CC cord-001397-nrq4ncdf 710 61 degradation degradation NN cord-001397-nrq4ncdf 710 62 of of IN cord-001397-nrq4ncdf 710 63 West West NNP cord-001397-nrq4ncdf 710 64 Nile Nile NNP cord-001397-nrq4ncdf 710 65 virus virus NN cord-001397-nrq4ncdf 710 66 capsid capsid NN cord-001397-nrq4ncdf 710 67 protein protein NN cord-001397-nrq4ncdf 710 68 Tick tick NN cord-001397-nrq4ncdf 710 69 - - HYPH cord-001397-nrq4ncdf 710 70 borne bear VBN cord-001397-nrq4ncdf 710 71 encephalitis encephalitis JJ cord-001397-nrq4ncdf 710 72 virus virus NN cord-001397-nrq4ncdf 710 73 delays delay NNS cord-001397-nrq4ncdf 710 74 interferon interferon VBP cord-001397-nrq4ncdf 710 75 induction induction NN cord-001397-nrq4ncdf 710 76 and and CC cord-001397-nrq4ncdf 710 77 hides hide VBZ cord-001397-nrq4ncdf 710 78 its -PRON- PRP$ cord-001397-nrq4ncdf 710 79 double double RB cord-001397-nrq4ncdf 710 80 - - HYPH cord-001397-nrq4ncdf 710 81 stranded strand VBN cord-001397-nrq4ncdf 710 82 RNA RNA NNP cord-001397-nrq4ncdf 710 83 in in IN cord-001397-nrq4ncdf 710 84 intracellular intracellular JJ cord-001397-nrq4ncdf 710 85 membrane membrane NN cord-001397-nrq4ncdf 710 86 vesicles vesicle NNS cord-001397-nrq4ncdf 710 87 Mice mouse NNS cord-001397-nrq4ncdf 710 88 with with IN cord-001397-nrq4ncdf 710 89 different different JJ cord-001397-nrq4ncdf 710 90 susceptibility susceptibility NN cord-001397-nrq4ncdf 710 91 to to TO cord-001397-nrq4ncdf 710 92 tick tick VB cord-001397-nrq4ncdf 710 93 - - HYPH cord-001397-nrq4ncdf 710 94 borne bear VBN cord-001397-nrq4ncdf 710 95 encephalitis encephalitis JJ cord-001397-nrq4ncdf 710 96 virus virus NN cord-001397-nrq4ncdf 710 97 infection infection NN cord-001397-nrq4ncdf 711 1 show show VB cord-001397-nrq4ncdf 711 2 selective selective JJ cord-001397-nrq4ncdf 711 3 neutralizing neutralize VBG cord-001397-nrq4ncdf 711 4 antibody antibody NN cord-001397-nrq4ncdf 711 5 response response NN cord-001397-nrq4ncdf 711 6 and and CC cord-001397-nrq4ncdf 711 7 inflammatory inflammatory JJ cord-001397-nrq4ncdf 711 8 reaction reaction NN cord-001397-nrq4ncdf 711 9 in in IN cord-001397-nrq4ncdf 711 10 the the DT cord-001397-nrq4ncdf 711 11 central central JJ cord-001397-nrq4ncdf 711 12 nervous nervous JJ cord-001397-nrq4ncdf 711 13 system system NN cord-001397-nrq4ncdf 711 14 Identification identification NN cord-001397-nrq4ncdf 711 15 of of IN cord-001397-nrq4ncdf 711 16 residues residue NNS cord-001397-nrq4ncdf 711 17 critical critical JJ cord-001397-nrq4ncdf 711 18 for for IN cord-001397-nrq4ncdf 711 19 the the DT cord-001397-nrq4ncdf 711 20 interferon interferon NN cord-001397-nrq4ncdf 711 21 antagonist antagonist NN cord-001397-nrq4ncdf 711 22 function function NN cord-001397-nrq4ncdf 711 23 of of IN cord-001397-nrq4ncdf 711 24 Langat Langat NNP cord-001397-nrq4ncdf 711 25 virus virus NN cord-001397-nrq4ncdf 711 26 NS5 NS5 NNP cord-001397-nrq4ncdf 711 27 reveals reveal VBZ cord-001397-nrq4ncdf 711 28 a a DT cord-001397-nrq4ncdf 711 29 role role NN cord-001397-nrq4ncdf 711 30 for for IN cord-001397-nrq4ncdf 711 31 the the DT cord-001397-nrq4ncdf 711 32 RNA RNA NNP cord-001397-nrq4ncdf 711 33 - - HYPH cord-001397-nrq4ncdf 711 34 dependent dependent JJ cord-001397-nrq4ncdf 711 35 RNA RNA NNP cord-001397-nrq4ncdf 711 36 polymerase polymerase NN cord-001397-nrq4ncdf 711 37 domain domain NN cord-001397-nrq4ncdf 711 38 Development development NN cord-001397-nrq4ncdf 711 39 of of IN cord-001397-nrq4ncdf 711 40 one one CD cord-001397-nrq4ncdf 711 41 - - HYPH cord-001397-nrq4ncdf 711 42 step step NN cord-001397-nrq4ncdf 711 43 quantitative quantitative JJ cord-001397-nrq4ncdf 711 44 reverse reverse NN cord-001397-nrq4ncdf 711 45 transcription transcription NN cord-001397-nrq4ncdf 711 46 PCR PCR NNP cord-001397-nrq4ncdf 711 47 for for IN cord-001397-nrq4ncdf 711 48 the the DT cord-001397-nrq4ncdf 711 49 rapid rapid JJ cord-001397-nrq4ncdf 711 50 detection detection NN cord-001397-nrq4ncdf 711 51 of of IN cord-001397-nrq4ncdf 711 52 flaviviruses flaviviruses NNP cord-001397-nrq4ncdf 711 53 Transmission Transmission NNP cord-001397-nrq4ncdf 711 54 of of IN cord-001397-nrq4ncdf 711 55 West West NNP cord-001397-nrq4ncdf 711 56 Nile Nile NNP cord-001397-nrq4ncdf 711 57 Virus Virus NNP cord-001397-nrq4ncdf 711 58 through through IN cord-001397-nrq4ncdf 711 59 blood blood NN cord-001397-nrq4ncdf 711 60 transfusion transfusion NN cord-001397-nrq4ncdf 711 61 in in IN cord-001397-nrq4ncdf 711 62 the the DT cord-001397-nrq4ncdf 711 63 United United NNP cord-001397-nrq4ncdf 711 64 States States NNP cord-001397-nrq4ncdf 711 65 in in IN cord-001397-nrq4ncdf 711 66 2002 2002 CD cord-001397-nrq4ncdf 712 1 Persistent persistent JJ cord-001397-nrq4ncdf 712 2 neuroinvasive neuroinvasive JJ cord-001397-nrq4ncdf 712 3 West West NNP cord-001397-nrq4ncdf 712 4 Nile Nile NNP cord-001397-nrq4ncdf 712 5 virus virus NN cord-001397-nrq4ncdf 712 6 infection infection NN cord-001397-nrq4ncdf 712 7 in in IN cord-001397-nrq4ncdf 712 8 an an DT cord-001397-nrq4ncdf 712 9 immunocompromised immunocompromised JJ cord-001397-nrq4ncdf 712 10 patient patient NN cord-001397-nrq4ncdf 712 11 Flavivirus Flavivirus NNP cord-001397-nrq4ncdf 712 12 entry entry NN cord-001397-nrq4ncdf 712 13 receptors receptor NNS cord-001397-nrq4ncdf 712 14 : : : cord-001397-nrq4ncdf 713 1 an an DT cord-001397-nrq4ncdf 713 2 update update NN cord-001397-nrq4ncdf 713 3 Internally internally RB cord-001397-nrq4ncdf 713 4 deleted delete VBN cord-001397-nrq4ncdf 713 5 WNV WNV NNP cord-001397-nrq4ncdf 713 6 genomes genome NNS cord-001397-nrq4ncdf 713 7 isolated isolate VBN cord-001397-nrq4ncdf 713 8 from from IN cord-001397-nrq4ncdf 713 9 exotic exotic JJ cord-001397-nrq4ncdf 713 10 birds bird NNS cord-001397-nrq4ncdf 713 11 in in IN cord-001397-nrq4ncdf 713 12 New New NNP cord-001397-nrq4ncdf 713 13 Mexico Mexico NNP cord-001397-nrq4ncdf 713 14 : : : cord-001397-nrq4ncdf 713 15 function function NN cord-001397-nrq4ncdf 713 16 in in IN cord-001397-nrq4ncdf 713 17 cells cell NNS cord-001397-nrq4ncdf 713 18 , , , cord-001397-nrq4ncdf 713 19 mosquitoes mosquito NNS cord-001397-nrq4ncdf 713 20 , , , cord-001397-nrq4ncdf 713 21 and and CC cord-001397-nrq4ncdf 713 22 mice mouse NNS cord-001397-nrq4ncdf 713 23 Modeling Modeling NNP cord-001397-nrq4ncdf 713 24 antibody antibody NN cord-001397-nrq4ncdf 713 25 - - HYPH cord-001397-nrq4ncdf 713 26 enhanced enhance VBN cord-001397-nrq4ncdf 713 27 Dengue Dengue NNP cord-001397-nrq4ncdf 713 28 virus virus NN cord-001397-nrq4ncdf 713 29 infection infection NN cord-001397-nrq4ncdf 713 30 and and CC cord-001397-nrq4ncdf 713 31 disease disease NN cord-001397-nrq4ncdf 713 32 in in IN cord-001397-nrq4ncdf 713 33 mice mouse NNS cord-001397-nrq4ncdf 713 34 : : : cord-001397-nrq4ncdf 713 35 protection protection NN cord-001397-nrq4ncdf 713 36 or or CC cord-001397-nrq4ncdf 713 37 pathogenesis pathogenesis NN cord-001397-nrq4ncdf 713 38 ? ? . cord-001397-nrq4ncdf 714 1 Degrees degree NNS cord-001397-nrq4ncdf 714 2 of of IN cord-001397-nrq4ncdf 714 3 maturity maturity NN cord-001397-nrq4ncdf 714 4 : : : cord-001397-nrq4ncdf 714 5 the the DT cord-001397-nrq4ncdf 714 6 complex complex JJ cord-001397-nrq4ncdf 714 7 structure structure NN cord-001397-nrq4ncdf 714 8 and and CC cord-001397-nrq4ncdf 714 9 biology biology NN cord-001397-nrq4ncdf 714 10 of of IN cord-001397-nrq4ncdf 714 11 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 714 12 Flaviviruses Flaviviruses NNP cord-001397-nrq4ncdf 714 13 : : : cord-001397-nrq4ncdf 714 14 braking brake VBG cord-001397-nrq4ncdf 714 15 the the DT cord-001397-nrq4ncdf 714 16 entering enter VBG cord-001397-nrq4ncdf 714 17 Virus Virus NNP cord-001397-nrq4ncdf 714 18 host host NN cord-001397-nrq4ncdf 714 19 co co NN cord-001397-nrq4ncdf 714 20 - - NN cord-001397-nrq4ncdf 714 21 evolution evolution NN cord-001397-nrq4ncdf 715 1 in in IN cord-001397-nrq4ncdf 715 2 a a DT cord-001397-nrq4ncdf 715 3 persistent persistent JJ cord-001397-nrq4ncdf 715 4 Coxsackievirus Coxsackievirus NNP cord-001397-nrq4ncdf 715 5 B3 b3 NN cord-001397-nrq4ncdf 715 6 infected infect VBN cord-001397-nrq4ncdf 715 7 cardiomyocyte cardiomyocyte NNP cord-001397-nrq4ncdf 715 8 cell cell NN cord-001397-nrq4ncdf 715 9 line line NN cord-001397-nrq4ncdf 715 10 Infectious infectious JJ cord-001397-nrq4ncdf 715 11 cDNA cdna NN cord-001397-nrq4ncdf 715 12 clone clone NN cord-001397-nrq4ncdf 715 13 of of IN cord-001397-nrq4ncdf 715 14 attenuated attenuated JJ cord-001397-nrq4ncdf 715 15 Langat Langat NNP cord-001397-nrq4ncdf 715 16 tick tick VB cord-001397-nrq4ncdf 715 17 - - HYPH cord-001397-nrq4ncdf 715 18 borne bear VBN cord-001397-nrq4ncdf 715 19 flavivirus flavivirus NN cord-001397-nrq4ncdf 715 20 ( ( -LRB- cord-001397-nrq4ncdf 715 21 strain strain NN cord-001397-nrq4ncdf 715 22 E5 E5 NNP cord-001397-nrq4ncdf 715 23 ) ) -RRB- cord-001397-nrq4ncdf 715 24 and and CC cord-001397-nrq4ncdf 715 25 a a DT cord-001397-nrq4ncdf 715 26 3 3 CD cord-001397-nrq4ncdf 715 27 0 0 CD cord-001397-nrq4ncdf 715 28 deletion deletion NN cord-001397-nrq4ncdf 715 29 mutant mutant NN cord-001397-nrq4ncdf 715 30 constructed construct VBN cord-001397-nrq4ncdf 715 31 from from IN cord-001397-nrq4ncdf 715 32 it -PRON- PRP cord-001397-nrq4ncdf 715 33 exhibit exhibit NN cord-001397-nrq4ncdf 715 34 decreased decrease VBD cord-001397-nrq4ncdf 715 35 neuroinvasiveness neuroinvasiveness NN cord-001397-nrq4ncdf 715 36 in in IN cord-001397-nrq4ncdf 715 37 immunodeficient immunodeficient JJ cord-001397-nrq4ncdf 715 38 mice mouse NNS cord-001397-nrq4ncdf 715 39 Persistence persistence NN cord-001397-nrq4ncdf 715 40 of of IN cord-001397-nrq4ncdf 715 41 the the DT cord-001397-nrq4ncdf 715 42 tick tick NN cord-001397-nrq4ncdf 715 43 - - HYPH cord-001397-nrq4ncdf 715 44 borne bear VBN cord-001397-nrq4ncdf 715 45 encephalitis encephalitis JJ cord-001397-nrq4ncdf 715 46 virus virus NN cord-001397-nrq4ncdf 715 47 and and CC cord-001397-nrq4ncdf 715 48 its -PRON- PRP$ cord-001397-nrq4ncdf 715 49 consequences consequence NNS cord-001397-nrq4ncdf 715 50 Persistence persistence NN cord-001397-nrq4ncdf 715 51 of of IN cord-001397-nrq4ncdf 715 52 tick tick NN cord-001397-nrq4ncdf 715 53 - - HYPH cord-001397-nrq4ncdf 715 54 borne bear VBN cord-001397-nrq4ncdf 715 55 encephalitis encephalitis JJ cord-001397-nrq4ncdf 715 56 virus virus NN cord-001397-nrq4ncdf 715 57 in in IN cord-001397-nrq4ncdf 715 58 monkeys monkey NNS cord-001397-nrq4ncdf 716 1 I -PRON- PRP cord-001397-nrq4ncdf 716 2 Features feature NNS cord-001397-nrq4ncdf 716 3 of of IN cord-001397-nrq4ncdf 716 4 experimental experimental JJ cord-001397-nrq4ncdf 716 5 infection infection NN cord-001397-nrq4ncdf 716 6 Study Study NNP cord-001397-nrq4ncdf 716 7 on on IN cord-001397-nrq4ncdf 716 8 West West NNP cord-001397-nrq4ncdf 716 9 Nile Nile NNP cord-001397-nrq4ncdf 716 10 virus virus NN cord-001397-nrq4ncdf 716 11 persistence persistence NN cord-001397-nrq4ncdf 716 12 in in IN cord-001397-nrq4ncdf 716 13 monkeys monkey NNS cord-001397-nrq4ncdf 716 14 Persistence persistence NN cord-001397-nrq4ncdf 716 15 of of IN cord-001397-nrq4ncdf 716 16 tick tick NN cord-001397-nrq4ncdf 716 17 - - HYPH cord-001397-nrq4ncdf 716 18 borne bear VBN cord-001397-nrq4ncdf 716 19 encephalitis encephalitis JJ cord-001397-nrq4ncdf 716 20 virus virus NN cord-001397-nrq4ncdf 716 21 in in IN cord-001397-nrq4ncdf 716 22 monkeys monkey NNS cord-001397-nrq4ncdf 717 1 VII VII NNP cord-001397-nrq4ncdf 718 1 Some some DT cord-001397-nrq4ncdf 718 2 features feature NNS cord-001397-nrq4ncdf 718 3 of of IN cord-001397-nrq4ncdf 718 4 the the DT cord-001397-nrq4ncdf 718 5 immune immune JJ cord-001397-nrq4ncdf 718 6 response response NN cord-001397-nrq4ncdf 719 1 Persistent persistent JJ cord-001397-nrq4ncdf 719 2 infection infection NN cord-001397-nrq4ncdf 719 3 of of IN cord-001397-nrq4ncdf 719 4 Vero Vero NNP cord-001397-nrq4ncdf 719 5 cells cell NNS cord-001397-nrq4ncdf 719 6 by by IN cord-001397-nrq4ncdf 719 7 the the DT cord-001397-nrq4ncdf 719 8 flavivirus flavivirus JJ cord-001397-nrq4ncdf 719 9 Murray Murray NNP cord-001397-nrq4ncdf 719 10 Valley Valley NNP cord-001397-nrq4ncdf 719 11 encephalitis encephalitis NN cord-001397-nrq4ncdf 719 12 virus virus NN cord-001397-nrq4ncdf 719 13 Infection infection NN cord-001397-nrq4ncdf 719 14 with with IN cord-001397-nrq4ncdf 719 15 Langat Langat NNP cord-001397-nrq4ncdf 719 16 flavivirus flavivirus NNP cord-001397-nrq4ncdf 719 17 or or CC cord-001397-nrq4ncdf 719 18 expression expression NN cord-001397-nrq4ncdf 719 19 of of IN cord-001397-nrq4ncdf 719 20 the the DT cord-001397-nrq4ncdf 719 21 envelope envelope NN cord-001397-nrq4ncdf 719 22 protein protein NN cord-001397-nrq4ncdf 719 23 induces induce VBZ cord-001397-nrq4ncdf 719 24 apoptotic apoptotic JJ cord-001397-nrq4ncdf 719 25 cell cell NN cord-001397-nrq4ncdf 719 26 death death NN cord-001397-nrq4ncdf 719 27 Langat Langat NNP cord-001397-nrq4ncdf 720 1 flavivirus flavivirus NNP cord-001397-nrq4ncdf 720 2 protease protease NN cord-001397-nrq4ncdf 720 3 NS3 ns3 RB cord-001397-nrq4ncdf 720 4 binds bind VBZ cord-001397-nrq4ncdf 720 5 caspase-8 caspase-8 NNP cord-001397-nrq4ncdf 720 6 and and CC cord-001397-nrq4ncdf 720 7 induces induce VBZ cord-001397-nrq4ncdf 720 8 apoptosis apoptosis NN cord-001397-nrq4ncdf 720 9 Persistence persistence NN cord-001397-nrq4ncdf 720 10 of of IN cord-001397-nrq4ncdf 720 11 antibodies antibody NNS cord-001397-nrq4ncdf 720 12 to to IN cord-001397-nrq4ncdf 720 13 West West NNP cord-001397-nrq4ncdf 720 14 Nile Nile NNP cord-001397-nrq4ncdf 720 15 virus virus NN cord-001397-nrq4ncdf 720 16 nonstructural nonstructural JJ cord-001397-nrq4ncdf 720 17 protein protein NN cord-001397-nrq4ncdf 720 18 5 5 CD cord-001397-nrq4ncdf 720 19 Nuclear nuclear JJ cord-001397-nrq4ncdf 720 20 localization localization NN cord-001397-nrq4ncdf 720 21 of of IN cord-001397-nrq4ncdf 720 22 dengue dengue NN cord-001397-nrq4ncdf 720 23 virus virus NN cord-001397-nrq4ncdf 720 24 nonstructural nonstructural JJ cord-001397-nrq4ncdf 720 25 protein protein NN cord-001397-nrq4ncdf 720 26 5 5 CD cord-001397-nrq4ncdf 720 27 through through IN cord-001397-nrq4ncdf 720 28 its -PRON- PRP$ cord-001397-nrq4ncdf 720 29 importin importin NNP cord-001397-nrq4ncdf 720 30 alpha alpha NN cord-001397-nrq4ncdf 720 31 / / SYM cord-001397-nrq4ncdf 720 32 beta beta NN cord-001397-nrq4ncdf 720 33 - - HYPH cord-001397-nrq4ncdf 720 34 recognized recognize VBN cord-001397-nrq4ncdf 720 35 nuclear nuclear JJ cord-001397-nrq4ncdf 720 36 localization localization NN cord-001397-nrq4ncdf 720 37 sequences sequence NNS cord-001397-nrq4ncdf 721 1 is be VBZ cord-001397-nrq4ncdf 721 2 integral integral JJ cord-001397-nrq4ncdf 721 3 to to IN cord-001397-nrq4ncdf 721 4 viral viral JJ cord-001397-nrq4ncdf 721 5 infection infection NN cord-001397-nrq4ncdf 721 6 Seroprevalence Seroprevalence NNP cord-001397-nrq4ncdf 721 7 study study NN cord-001397-nrq4ncdf 721 8 of of IN cord-001397-nrq4ncdf 721 9 tick tick NN cord-001397-nrq4ncdf 721 10 - - HYPH cord-001397-nrq4ncdf 721 11 borne bear VBN cord-001397-nrq4ncdf 721 12 encephalitis encephalitis RB cord-001397-nrq4ncdf 721 13 , , , cord-001397-nrq4ncdf 721 14 Borrelia Borrelia NNP cord-001397-nrq4ncdf 721 15 burgdorferi burgdorferi NN cord-001397-nrq4ncdf 721 16 , , , cord-001397-nrq4ncdf 721 17 Dengue Dengue NNP cord-001397-nrq4ncdf 721 18 and and CC cord-001397-nrq4ncdf 721 19 Toscana Toscana NNP cord-001397-nrq4ncdf 721 20 virus virus NN cord-001397-nrq4ncdf 721 21 in in IN cord-001397-nrq4ncdf 721 22 Turin Turin NNP cord-001397-nrq4ncdf 721 23 Province Province NNP cord-001397-nrq4ncdf 721 24 Isolation Isolation NNP cord-001397-nrq4ncdf 721 25 of of IN cord-001397-nrq4ncdf 721 26 Kyasanur Kyasanur NNP cord-001397-nrq4ncdf 721 27 forest forest NN cord-001397-nrq4ncdf 721 28 disease disease NN cord-001397-nrq4ncdf 721 29 virus virus NN cord-001397-nrq4ncdf 721 30 from from IN cord-001397-nrq4ncdf 721 31 the the DT cord-001397-nrq4ncdf 721 32 insectivorous insectivorous JJ cord-001397-nrq4ncdf 721 33 bat bat NN cord-001397-nrq4ncdf 721 34 , , , cord-001397-nrq4ncdf 721 35 Rhinolophus Rhinolophus NNP cord-001397-nrq4ncdf 721 36 rouxi rouxi NN cord-001397-nrq4ncdf 721 37 and and CC cord-001397-nrq4ncdf 721 38 from from IN cord-001397-nrq4ncdf 721 39 Ornithodoros Ornithodoros NNP cord-001397-nrq4ncdf 721 40 ticks tick VBZ cord-001397-nrq4ncdf 721 41 Host Host NNP cord-001397-nrq4ncdf 721 42 cell cell NN cord-001397-nrq4ncdf 721 43 killing kill VBG cord-001397-nrq4ncdf 721 44 by by IN cord-001397-nrq4ncdf 721 45 the the DT cord-001397-nrq4ncdf 721 46 West West NNP cord-001397-nrq4ncdf 721 47 Nile Nile NNP cord-001397-nrq4ncdf 721 48 Virus Virus NNP cord-001397-nrq4ncdf 721 49 NS2B NS2B NNP cord-001397-nrq4ncdf 721 50 - - : cord-001397-nrq4ncdf 721 51 NS3 ns3 RB cord-001397-nrq4ncdf 721 52 proteolytic proteolytic JJ cord-001397-nrq4ncdf 721 53 complex complex NN cord-001397-nrq4ncdf 721 54 : : : cord-001397-nrq4ncdf 722 1 NS3 ns3 RB cord-001397-nrq4ncdf 722 2 alone alone RB cord-001397-nrq4ncdf 722 3 is be VBZ cord-001397-nrq4ncdf 722 4 sufficient sufficient JJ cord-001397-nrq4ncdf 722 5 to to TO cord-001397-nrq4ncdf 722 6 recruit recruit VB cord-001397-nrq4ncdf 722 7 caspase-8-based caspase-8-based JJ cord-001397-nrq4ncdf 722 8 apoptotic apoptotic JJ cord-001397-nrq4ncdf 722 9 pathway pathway NN cord-001397-nrq4ncdf 722 10 Persistence persistence NN cord-001397-nrq4ncdf 722 11 of of IN cord-001397-nrq4ncdf 722 12 Japanese japanese JJ cord-001397-nrq4ncdf 722 13 encephalitis encephalitis RB cord-001397-nrq4ncdf 722 14 virus virus NN cord-001397-nrq4ncdf 722 15 in in IN cord-001397-nrq4ncdf 722 16 the the DT cord-001397-nrq4ncdf 722 17 human human JJ cord-001397-nrq4ncdf 722 18 nervous nervous JJ cord-001397-nrq4ncdf 722 19 system system NN cord-001397-nrq4ncdf 722 20 CRM1-mediated CRM1-mediated NNP cord-001397-nrq4ncdf 722 21 nuclear nuclear JJ cord-001397-nrq4ncdf 722 22 export export NN cord-001397-nrq4ncdf 722 23 of of IN cord-001397-nrq4ncdf 722 24 dengue dengue NN cord-001397-nrq4ncdf 722 25 virus virus NN cord-001397-nrq4ncdf 722 26 RNA rna NN cord-001397-nrq4ncdf 722 27 polymerase polymerase NN cord-001397-nrq4ncdf 722 28 NS5 NS5 NNP cord-001397-nrq4ncdf 722 29 modulates modulate VBZ cord-001397-nrq4ncdf 722 30 interleukin-8 interleukin-8 NNP cord-001397-nrq4ncdf 722 31 induction induction NN cord-001397-nrq4ncdf 722 32 and and CC cord-001397-nrq4ncdf 722 33 virus virus NN cord-001397-nrq4ncdf 722 34 production production NN cord-001397-nrq4ncdf 722 35 Persistence persistence NN cord-001397-nrq4ncdf 722 36 of of IN cord-001397-nrq4ncdf 722 37 protective protective JJ cord-001397-nrq4ncdf 722 38 immunity immunity NN cord-001397-nrq4ncdf 722 39 following follow VBG cord-001397-nrq4ncdf 722 40 vaccination vaccination NN cord-001397-nrq4ncdf 722 41 against against IN cord-001397-nrq4ncdf 722 42 tick tick NN cord-001397-nrq4ncdf 722 43 - - HYPH cord-001397-nrq4ncdf 722 44 borne bear VBN cord-001397-nrq4ncdf 722 45 encephalitislonger encephalitislonger NN cord-001397-nrq4ncdf 722 46 than than IN cord-001397-nrq4ncdf 722 47 expected expect VBN cord-001397-nrq4ncdf 722 48 The the DT cord-001397-nrq4ncdf 722 49 envelope envelope NN cord-001397-nrq4ncdf 722 50 glycoprotein glycoprotein NN cord-001397-nrq4ncdf 722 51 from from IN cord-001397-nrq4ncdf 722 52 tick tick NN cord-001397-nrq4ncdf 722 53 - - HYPH cord-001397-nrq4ncdf 722 54 borne bear VBN cord-001397-nrq4ncdf 722 55 encephalitis encephalitis JJ cord-001397-nrq4ncdf 722 56 virus virus NN cord-001397-nrq4ncdf 722 57 at at IN cord-001397-nrq4ncdf 722 58 2 2 CD cord-001397-nrq4ncdf 722 59 A a DT cord-001397-nrq4ncdf 722 60 resolution resolution NN cord-001397-nrq4ncdf 722 61 Tick tick NN cord-001397-nrq4ncdf 722 62 - - HYPH cord-001397-nrq4ncdf 722 63 borne bear VBN cord-001397-nrq4ncdf 722 64 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 722 65 : : : cord-001397-nrq4ncdf 722 66 dissecting dissect VBG cord-001397-nrq4ncdf 722 67 host host NN cord-001397-nrq4ncdf 722 68 immune immune JJ cord-001397-nrq4ncdf 722 69 responses response NNS cord-001397-nrq4ncdf 722 70 and and CC cord-001397-nrq4ncdf 722 71 virus virus NN cord-001397-nrq4ncdf 722 72 countermeasures countermeasure NNS cord-001397-nrq4ncdf 722 73 Regulated regulate VBN cord-001397-nrq4ncdf 722 74 cleavages cleavage NNS cord-001397-nrq4ncdf 722 75 at at IN cord-001397-nrq4ncdf 722 76 the the DT cord-001397-nrq4ncdf 722 77 West West NNP cord-001397-nrq4ncdf 722 78 Nile Nile NNP cord-001397-nrq4ncdf 722 79 virus virus NN cord-001397-nrq4ncdf 723 1 NS4A-2K ns4a-2k NN cord-001397-nrq4ncdf 723 2 - - HYPH cord-001397-nrq4ncdf 723 3 NS4B NS4B NNP cord-001397-nrq4ncdf 723 4 junctions junction NNS cord-001397-nrq4ncdf 723 5 play play VBP cord-001397-nrq4ncdf 723 6 a a DT cord-001397-nrq4ncdf 723 7 major major JJ cord-001397-nrq4ncdf 723 8 role role NN cord-001397-nrq4ncdf 723 9 in in IN cord-001397-nrq4ncdf 723 10 rearranging rearrange VBG cord-001397-nrq4ncdf 723 11 cytoplasmic cytoplasmic JJ cord-001397-nrq4ncdf 723 12 membranes membrane NNS cord-001397-nrq4ncdf 723 13 and and CC cord-001397-nrq4ncdf 723 14 Golgi Golgi NNP cord-001397-nrq4ncdf 723 15 trafficking trafficking NN cord-001397-nrq4ncdf 723 16 of of IN cord-001397-nrq4ncdf 723 17 the the DT cord-001397-nrq4ncdf 723 18 NS4A NS4A NNP cord-001397-nrq4ncdf 723 19 protein protein NN cord-001397-nrq4ncdf 723 20 Serologic Serologic NNP cord-001397-nrq4ncdf 723 21 evidence evidence NN cord-001397-nrq4ncdf 723 22 of of IN cord-001397-nrq4ncdf 723 23 exposure exposure NN cord-001397-nrq4ncdf 723 24 of of IN cord-001397-nrq4ncdf 723 25 wild wild JJ cord-001397-nrq4ncdf 723 26 animals animal NNS cord-001397-nrq4ncdf 723 27 to to IN cord-001397-nrq4ncdf 723 28 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 723 29 in in IN cord-001397-nrq4ncdf 723 30 the the DT cord-001397-nrq4ncdf 723 31 central central JJ cord-001397-nrq4ncdf 723 32 and and CC cord-001397-nrq4ncdf 723 33 eastern eastern JJ cord-001397-nrq4ncdf 723 34 United United NNP cord-001397-nrq4ncdf 723 35 States States NNP cord-001397-nrq4ncdf 723 36 Transovarial Transovarial NNP cord-001397-nrq4ncdf 723 37 transmission transmission NN cord-001397-nrq4ncdf 723 38 of of IN cord-001397-nrq4ncdf 723 39 Dengue dengue NN cord-001397-nrq4ncdf 723 40 viruses virus NNS cord-001397-nrq4ncdf 723 41 by by IN cord-001397-nrq4ncdf 723 42 mosquitoes mosquito NNS cord-001397-nrq4ncdf 723 43 : : : cord-001397-nrq4ncdf 724 1 Aedes Aedes NNP cord-001397-nrq4ncdf 724 2 albopictus albopictus NN cord-001397-nrq4ncdf 724 3 and and CC cord-001397-nrq4ncdf 724 4 Aedes Aedes NNP cord-001397-nrq4ncdf 724 5 aegypti aegypti NN cord-001397-nrq4ncdf 724 6 Local local JJ cord-001397-nrq4ncdf 724 7 impact impact NN cord-001397-nrq4ncdf 724 8 of of IN cord-001397-nrq4ncdf 724 9 temperature temperature NN cord-001397-nrq4ncdf 724 10 and and CC cord-001397-nrq4ncdf 724 11 precipitation precipitation NN cord-001397-nrq4ncdf 724 12 on on IN cord-001397-nrq4ncdf 724 13 West West NNP cord-001397-nrq4ncdf 724 14 Nile Nile NNP cord-001397-nrq4ncdf 724 15 virus virus NN cord-001397-nrq4ncdf 724 16 infection infection NN cord-001397-nrq4ncdf 724 17 in in IN cord-001397-nrq4ncdf 724 18 Culex Culex NNP cord-001397-nrq4ncdf 724 19 species specie VBZ cord-001397-nrq4ncdf 724 20 mosquitoes mosquito NNS cord-001397-nrq4ncdf 724 21 in in IN cord-001397-nrq4ncdf 724 22 northeast northeast JJ cord-001397-nrq4ncdf 724 23 Illinois Illinois NNP cord-001397-nrq4ncdf 724 24 Virus Virus NNP cord-001397-nrq4ncdf 724 25 - - HYPH cord-001397-nrq4ncdf 724 26 encoded encode VBN cord-001397-nrq4ncdf 724 27 proteinases proteinase NNS cord-001397-nrq4ncdf 724 28 of of IN cord-001397-nrq4ncdf 724 29 the the DT cord-001397-nrq4ncdf 724 30 Flaviviridae Flaviviridae NNP cord-001397-nrq4ncdf 724 31 Persistent Persistent NNP cord-001397-nrq4ncdf 724 32 neuropsychological neuropsychological JJ cord-001397-nrq4ncdf 724 33 impairment impairment NN cord-001397-nrq4ncdf 724 34 associated associate VBN cord-001397-nrq4ncdf 724 35 with with IN cord-001397-nrq4ncdf 724 36 West West NNP cord-001397-nrq4ncdf 724 37 Nile Nile NNP cord-001397-nrq4ncdf 724 38 virus virus NN cord-001397-nrq4ncdf 724 39 infection infection NN cord-001397-nrq4ncdf 724 40 Hamster Hamster NNP cord-001397-nrq4ncdf 724 41 - - HYPH cord-001397-nrq4ncdf 724 42 adapted adapt VBN cord-001397-nrq4ncdf 724 43 Sin Sin NNP cord-001397-nrq4ncdf 724 44 Nombre Nombre NNP cord-001397-nrq4ncdf 724 45 virus virus NN cord-001397-nrq4ncdf 724 46 causes cause VBZ cord-001397-nrq4ncdf 724 47 disseminated disseminate VBN cord-001397-nrq4ncdf 724 48 infection infection NN cord-001397-nrq4ncdf 724 49 and and CC cord-001397-nrq4ncdf 724 50 efficiently efficiently RB cord-001397-nrq4ncdf 724 51 replicates replicate VBZ cord-001397-nrq4ncdf 724 52 in in IN cord-001397-nrq4ncdf 724 53 pulmonary pulmonary JJ cord-001397-nrq4ncdf 724 54 endothelial endothelial JJ cord-001397-nrq4ncdf 724 55 cells cell NNS cord-001397-nrq4ncdf 724 56 without without IN cord-001397-nrq4ncdf 724 57 signs sign NNS cord-001397-nrq4ncdf 724 58 of of IN cord-001397-nrq4ncdf 724 59 disease disease NN cord-001397-nrq4ncdf 724 60 Molecular molecular JJ cord-001397-nrq4ncdf 724 61 basis basis NN cord-001397-nrq4ncdf 724 62 of of IN cord-001397-nrq4ncdf 724 63 viral viral JJ cord-001397-nrq4ncdf 724 64 persistence persistence NN cord-001397-nrq4ncdf 724 65 : : : cord-001397-nrq4ncdf 724 66 a a DT cord-001397-nrq4ncdf 724 67 single single JJ cord-001397-nrq4ncdf 724 68 amino amino NN cord-001397-nrq4ncdf 724 69 acid acid NN cord-001397-nrq4ncdf 724 70 change change NN cord-001397-nrq4ncdf 724 71 in in IN cord-001397-nrq4ncdf 724 72 the the DT cord-001397-nrq4ncdf 724 73 glycoprotein glycoprotein NN cord-001397-nrq4ncdf 724 74 of of IN cord-001397-nrq4ncdf 724 75 lymphocytic lymphocytic JJ cord-001397-nrq4ncdf 724 76 choriomeningitis choriomeningitis NNP cord-001397-nrq4ncdf 724 77 virus virus NN cord-001397-nrq4ncdf 724 78 is be VBZ cord-001397-nrq4ncdf 724 79 associated associate VBN cord-001397-nrq4ncdf 724 80 with with IN cord-001397-nrq4ncdf 724 81 suppression suppression NN cord-001397-nrq4ncdf 724 82 of of IN cord-001397-nrq4ncdf 724 83 the the DT cord-001397-nrq4ncdf 724 84 antiviral antiviral JJ cord-001397-nrq4ncdf 724 85 cytotoxic cytotoxic JJ cord-001397-nrq4ncdf 724 86 T t NN cord-001397-nrq4ncdf 724 87 - - HYPH cord-001397-nrq4ncdf 724 88 lymphocyte lymphocyte NN cord-001397-nrq4ncdf 724 89 response response NN cord-001397-nrq4ncdf 724 90 and and CC cord-001397-nrq4ncdf 724 91 establishment establishment NN cord-001397-nrq4ncdf 724 92 of of IN cord-001397-nrq4ncdf 724 93 persistence persistence NN cord-001397-nrq4ncdf 724 94 A a DT cord-001397-nrq4ncdf 724 95 single single JJ cord-001397-nrq4ncdf 724 96 nucleotide nucleotide JJ cord-001397-nrq4ncdf 724 97 change change NN cord-001397-nrq4ncdf 724 98 in in IN cord-001397-nrq4ncdf 724 99 the the DT cord-001397-nrq4ncdf 724 100 E e NN cord-001397-nrq4ncdf 724 101 protein protein NN cord-001397-nrq4ncdf 724 102 gene gene NN cord-001397-nrq4ncdf 724 103 of of IN cord-001397-nrq4ncdf 724 104 dengue dengue NN cord-001397-nrq4ncdf 724 105 virus virus NN cord-001397-nrq4ncdf 724 106 2 2 CD cord-001397-nrq4ncdf 724 107 Mexican mexican JJ cord-001397-nrq4ncdf 724 108 strain strain NN cord-001397-nrq4ncdf 724 109 affects affect VBZ cord-001397-nrq4ncdf 724 110 neurovirulence neurovirulence NN cord-001397-nrq4ncdf 724 111 in in IN cord-001397-nrq4ncdf 724 112 mice mouse NNS cord-001397-nrq4ncdf 724 113 Generic Generic NNP cord-001397-nrq4ncdf 724 114 RT RT NNP cord-001397-nrq4ncdf 724 115 - - HYPH cord-001397-nrq4ncdf 724 116 nested nest VBN cord-001397-nrq4ncdf 724 117 - - HYPH cord-001397-nrq4ncdf 724 118 PCR PCR NNP cord-001397-nrq4ncdf 724 119 for for IN cord-001397-nrq4ncdf 724 120 detection detection NN cord-001397-nrq4ncdf 724 121 of of IN cord-001397-nrq4ncdf 724 122 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 724 123 using use VBG cord-001397-nrq4ncdf 724 124 degenerated degenerate VBN cord-001397-nrq4ncdf 724 125 primers primer NNS cord-001397-nrq4ncdf 724 126 and and CC cord-001397-nrq4ncdf 724 127 internal internal JJ cord-001397-nrq4ncdf 724 128 control control NN cord-001397-nrq4ncdf 724 129 followed follow VBN cord-001397-nrq4ncdf 724 130 by by IN cord-001397-nrq4ncdf 724 131 sequencing sequence VBG cord-001397-nrq4ncdf 724 132 for for IN cord-001397-nrq4ncdf 724 133 specific specific JJ cord-001397-nrq4ncdf 724 134 identification identification NN cord-001397-nrq4ncdf 724 135 Dengue dengue NN cord-001397-nrq4ncdf 724 136 virus virus NN cord-001397-nrq4ncdf 724 137 type type NN cord-001397-nrq4ncdf 724 138 2 2 CD cord-001397-nrq4ncdf 724 139 infections infection NNS cord-001397-nrq4ncdf 724 140 of of IN cord-001397-nrq4ncdf 724 141 Aedes Aedes NNP cord-001397-nrq4ncdf 724 142 aegypti aegypti NNS cord-001397-nrq4ncdf 724 143 are be VBP cord-001397-nrq4ncdf 724 144 modulated modulate VBN cord-001397-nrq4ncdf 724 145 by by IN cord-001397-nrq4ncdf 724 146 the the DT cord-001397-nrq4ncdf 724 147 mosquito mosquito NN cord-001397-nrq4ncdf 724 148 's 's POS cord-001397-nrq4ncdf 724 149 RNA RNA NNP cord-001397-nrq4ncdf 724 150 interference interference NN cord-001397-nrq4ncdf 724 151 pathway pathway NN cord-001397-nrq4ncdf 724 152 A a DT cord-001397-nrq4ncdf 724 153 hamster hamster NN cord-001397-nrq4ncdf 724 154 - - HYPH cord-001397-nrq4ncdf 724 155 derived derive VBN cord-001397-nrq4ncdf 724 156 West West NNP cord-001397-nrq4ncdf 724 157 Nile Nile NNP cord-001397-nrq4ncdf 724 158 virus virus NN cord-001397-nrq4ncdf 724 159 isolate isolate VBP cord-001397-nrq4ncdf 724 160 induces induce VBZ cord-001397-nrq4ncdf 724 161 persistent persistent JJ cord-001397-nrq4ncdf 724 162 renal renal JJ cord-001397-nrq4ncdf 724 163 infection infection NN cord-001397-nrq4ncdf 724 164 in in IN cord-001397-nrq4ncdf 724 165 mice mice NN cord-001397-nrq4ncdf 724 166 Persistent persistent JJ cord-001397-nrq4ncdf 724 167 infection infection NN cord-001397-nrq4ncdf 724 168 of of IN cord-001397-nrq4ncdf 724 169 cultured cultured JJ cord-001397-nrq4ncdf 724 170 mammalian mammalian JJ cord-001397-nrq4ncdf 724 171 cells cell NNS cord-001397-nrq4ncdf 724 172 by by IN cord-001397-nrq4ncdf 724 173 Japanese japanese JJ cord-001397-nrq4ncdf 724 174 encephalitis encephalitis JJ cord-001397-nrq4ncdf 724 175 virus virus NN cord-001397-nrq4ncdf 724 176 Kinetics kinetic NNS cord-001397-nrq4ncdf 724 177 of of IN cord-001397-nrq4ncdf 724 178 immune immune JJ cord-001397-nrq4ncdf 724 179 responses response NNS cord-001397-nrq4ncdf 724 180 in in IN cord-001397-nrq4ncdf 724 181 deer deer NN cord-001397-nrq4ncdf 724 182 mice mouse NNS cord-001397-nrq4ncdf 724 183 experimentally experimentally RB cord-001397-nrq4ncdf 724 184 infected infect VBN cord-001397-nrq4ncdf 724 185 with with IN cord-001397-nrq4ncdf 724 186 Sin Sin NNP cord-001397-nrq4ncdf 724 187 Nombre Nombre NNP cord-001397-nrq4ncdf 724 188 virus virus NN cord-001397-nrq4ncdf 724 189 Dengue dengue NN cord-001397-nrq4ncdf 724 190 virus virus NN cord-001397-nrq4ncdf 724 191 type type NN cord-001397-nrq4ncdf 724 192 2 2 CD cord-001397-nrq4ncdf 724 193 NS3 ns3 RB cord-001397-nrq4ncdf 724 194 protease protease NN cord-001397-nrq4ncdf 724 195 and and CC cord-001397-nrq4ncdf 725 1 NS2B NS2B NNP cord-001397-nrq4ncdf 725 2 - - : cord-001397-nrq4ncdf 725 3 NS3 ns3 RB cord-001397-nrq4ncdf 725 4 protease protease NN cord-001397-nrq4ncdf 725 5 precursor precursor NN cord-001397-nrq4ncdf 725 6 induce induce VBP cord-001397-nrq4ncdf 725 7 apoptosis apoptosis NN cord-001397-nrq4ncdf 725 8 Japanese japanese JJ cord-001397-nrq4ncdf 725 9 encephalitis encephalitis RB cord-001397-nrq4ncdf 725 10 virus virus NN cord-001397-nrq4ncdf 725 11 latency latency NN cord-001397-nrq4ncdf 725 12 in in IN cord-001397-nrq4ncdf 725 13 peripheral peripheral JJ cord-001397-nrq4ncdf 725 14 blood blood NN cord-001397-nrq4ncdf 725 15 lymphocytes lymphocyte NNS cord-001397-nrq4ncdf 725 16 and and CC cord-001397-nrq4ncdf 725 17 recurrence recurrence NN cord-001397-nrq4ncdf 725 18 of of IN cord-001397-nrq4ncdf 725 19 infection infection NN cord-001397-nrq4ncdf 725 20 in in IN cord-001397-nrq4ncdf 725 21 children child NNS cord-001397-nrq4ncdf 725 22 Viral viral JJ cord-001397-nrq4ncdf 725 23 and and CC cord-001397-nrq4ncdf 725 24 cellular cellular JJ cord-001397-nrq4ncdf 725 25 proteins protein NNS cord-001397-nrq4ncdf 725 26 involved involve VBN cord-001397-nrq4ncdf 725 27 in in IN cord-001397-nrq4ncdf 725 28 coronavirus coronavirus NN cord-001397-nrq4ncdf 725 29 replication replication NN cord-001397-nrq4ncdf 725 30 Role role NN cord-001397-nrq4ncdf 725 31 of of IN cord-001397-nrq4ncdf 725 32 CD8 CD8 NNP cord-001397-nrq4ncdf 725 33 + + CC cord-001397-nrq4ncdf 725 34 T T NNP cord-001397-nrq4ncdf 725 35 cells cell NNS cord-001397-nrq4ncdf 725 36 in in IN cord-001397-nrq4ncdf 725 37 control control NN cord-001397-nrq4ncdf 725 38 of of IN cord-001397-nrq4ncdf 725 39 West West NNP cord-001397-nrq4ncdf 725 40 Nile Nile NNP cord-001397-nrq4ncdf 725 41 virus virus NN cord-001397-nrq4ncdf 725 42 infection infection NN cord-001397-nrq4ncdf 725 43 Chronic Chronic NNP cord-001397-nrq4ncdf 725 44 St St NNP cord-001397-nrq4ncdf 725 45 Louis Louis NNP cord-001397-nrq4ncdf 725 46 encephalitis encephalitis RB cord-001397-nrq4ncdf 725 47 virus virus NN cord-001397-nrq4ncdf 725 48 infection infection NN cord-001397-nrq4ncdf 725 49 in in IN cord-001397-nrq4ncdf 725 50 the the DT cord-001397-nrq4ncdf 725 51 golden golden JJ cord-001397-nrq4ncdf 725 52 hamster hamster NN cord-001397-nrq4ncdf 725 53 ( ( -LRB- cord-001397-nrq4ncdf 725 54 Mesocricetus Mesocricetus NNP cord-001397-nrq4ncdf 725 55 auratus auratus NN cord-001397-nrq4ncdf 725 56 ) ) -RRB- cord-001397-nrq4ncdf 726 1 Rodenhuis Rodenhuis NNP cord-001397-nrq4ncdf 726 2 - - HYPH cord-001397-nrq4ncdf 726 3 Zybert Zybert NNP cord-001397-nrq4ncdf 726 4 I I NNP cord-001397-nrq4ncdf 726 5 & & CC cord-001397-nrq4ncdf 726 6 Wilschut Wilschut NNP cord-001397-nrq4ncdf 726 7 J J NNP cord-001397-nrq4ncdf 726 8 ( ( -LRB- cord-001397-nrq4ncdf 726 9 2011 2011 CD cord-001397-nrq4ncdf 726 10 ) ) -RRB- cord-001397-nrq4ncdf 727 1 Flavivirus Flavivirus NNP cord-001397-nrq4ncdf 727 2 cell cell NN cord-001397-nrq4ncdf 727 3 entry entry NN cord-001397-nrq4ncdf 727 4 and and CC cord-001397-nrq4ncdf 727 5 membrane membrane NN cord-001397-nrq4ncdf 727 6 fusion fusion NN cord-001397-nrq4ncdf 727 7 Genetic genetic JJ cord-001397-nrq4ncdf 727 8 resistance resistance NN cord-001397-nrq4ncdf 727 9 to to IN cord-001397-nrq4ncdf 727 10 lethal lethal JJ cord-001397-nrq4ncdf 727 11 flavivirus flavivirus NNP cord-001397-nrq4ncdf 727 12 encephalitis encephalitis NN cord-001397-nrq4ncdf 727 13 : : : cord-001397-nrq4ncdf 727 14 effect effect NN cord-001397-nrq4ncdf 727 15 of of IN cord-001397-nrq4ncdf 727 16 host host NN cord-001397-nrq4ncdf 727 17 age age NN cord-001397-nrq4ncdf 727 18 and and CC cord-001397-nrq4ncdf 727 19 immune immune JJ cord-001397-nrq4ncdf 727 20 status status NN cord-001397-nrq4ncdf 727 21 and and CC cord-001397-nrq4ncdf 727 22 route route NN cord-001397-nrq4ncdf 727 23 of of IN cord-001397-nrq4ncdf 727 24 inoculation inoculation NN cord-001397-nrq4ncdf 727 25 on on IN cord-001397-nrq4ncdf 727 26 production production NN cord-001397-nrq4ncdf 727 27 of of IN cord-001397-nrq4ncdf 727 28 interfering interfere VBG cord-001397-nrq4ncdf 727 29 Banzi Banzi NNP cord-001397-nrq4ncdf 727 30 virus virus NN cord-001397-nrq4ncdf 727 31 in in IN cord-001397-nrq4ncdf 727 32 vivo vivo NNP cord-001397-nrq4ncdf 727 33 Poliomyelitis poliomyelitis NN cord-001397-nrq4ncdf 727 34 - - HYPH cord-001397-nrq4ncdf 727 35 like like JJ cord-001397-nrq4ncdf 727 36 illness illness NN cord-001397-nrq4ncdf 727 37 due due IN cord-001397-nrq4ncdf 727 38 to to IN cord-001397-nrq4ncdf 727 39 Japanese japanese JJ cord-001397-nrq4ncdf 727 40 encephalitis encephalitis JJ cord-001397-nrq4ncdf 727 41 virus virus NN cord-001397-nrq4ncdf 727 42 Pathology Pathology NNP cord-001397-nrq4ncdf 727 43 of of IN cord-001397-nrq4ncdf 727 44 Fatal Fatal NNP cord-001397-nrq4ncdf 727 45 West West NNP cord-001397-nrq4ncdf 727 46 Nile Nile NNP cord-001397-nrq4ncdf 727 47 virus virus NN cord-001397-nrq4ncdf 727 48 infections infection NNS cord-001397-nrq4ncdf 727 49 in in IN cord-001397-nrq4ncdf 727 50 native native JJ cord-001397-nrq4ncdf 727 51 and and CC cord-001397-nrq4ncdf 727 52 exotic exotic JJ cord-001397-nrq4ncdf 727 53 birds bird NNS cord-001397-nrq4ncdf 727 54 during during IN cord-001397-nrq4ncdf 727 55 the the DT cord-001397-nrq4ncdf 727 56 1999 1999 CD cord-001397-nrq4ncdf 727 57 outbreak outbreak NN cord-001397-nrq4ncdf 727 58 West West NNP cord-001397-nrq4ncdf 727 59 Nile Nile NNP cord-001397-nrq4ncdf 727 60 virus virus NN cord-001397-nrq4ncdf 727 61 infection infection NN cord-001397-nrq4ncdf 727 62 in in IN cord-001397-nrq4ncdf 727 63 crocodiles crocodile NNS cord-001397-nrq4ncdf 727 64 Persistence Persistence NNP cord-001397-nrq4ncdf 727 65 of of IN cord-001397-nrq4ncdf 727 66 virus virus NN cord-001397-nrq4ncdf 727 67 - - HYPH cord-001397-nrq4ncdf 727 68 specific specific JJ cord-001397-nrq4ncdf 727 69 immune immune JJ cord-001397-nrq4ncdf 727 70 responses response NNS cord-001397-nrq4ncdf 727 71 in in IN cord-001397-nrq4ncdf 727 72 the the DT cord-001397-nrq4ncdf 727 73 central central JJ cord-001397-nrq4ncdf 727 74 nervous nervous JJ cord-001397-nrq4ncdf 727 75 system system NN cord-001397-nrq4ncdf 727 76 of of IN cord-001397-nrq4ncdf 727 77 mice mouse NNS cord-001397-nrq4ncdf 727 78 after after IN cord-001397-nrq4ncdf 727 79 West West NNP cord-001397-nrq4ncdf 727 80 Nile Nile NNP cord-001397-nrq4ncdf 727 81 virus virus NN cord-001397-nrq4ncdf 727 82 infection infection NN cord-001397-nrq4ncdf 727 83 Quantitative quantitative JJ cord-001397-nrq4ncdf 727 84 determination determination NN cord-001397-nrq4ncdf 727 85 of of IN cord-001397-nrq4ncdf 727 86 IgM IgM NNP cord-001397-nrq4ncdf 727 87 antibodies antibody NNS cord-001397-nrq4ncdf 727 88 reduces reduce VBZ cord-001397-nrq4ncdf 727 89 the the DT cord-001397-nrq4ncdf 727 90 pitfalls pitfall NNS cord-001397-nrq4ncdf 727 91 in in IN cord-001397-nrq4ncdf 727 92 the the DT cord-001397-nrq4ncdf 727 93 serodiagnosis serodiagnosis NN cord-001397-nrq4ncdf 727 94 of of IN cord-001397-nrq4ncdf 727 95 tick tick VB cord-001397-nrq4ncdf 727 96 - - HYPH cord-001397-nrq4ncdf 727 97 borne bear VBN cord-001397-nrq4ncdf 727 98 encephalitis encephalitis JJ cord-001397-nrq4ncdf 727 99 West West NNP cord-001397-nrq4ncdf 727 100 Nile Nile NNP cord-001397-nrq4ncdf 727 101 encephalitis encephalitis RB cord-001397-nrq4ncdf 727 102 : : : cord-001397-nrq4ncdf 728 1 an an DT cord-001397-nrq4ncdf 728 2 emerging emerge VBG cord-001397-nrq4ncdf 728 3 disease disease NN cord-001397-nrq4ncdf 728 4 in in IN cord-001397-nrq4ncdf 728 5 the the DT cord-001397-nrq4ncdf 728 6 United United NNP cord-001397-nrq4ncdf 728 7 States States NNP cord-001397-nrq4ncdf 728 8 Type Type NNP cord-001397-nrq4ncdf 728 9 - - : cord-001397-nrq4ncdf 728 10 and and CC cord-001397-nrq4ncdf 728 11 subcomplex subcomplex RB cord-001397-nrq4ncdf 728 12 - - HYPH cord-001397-nrq4ncdf 728 13 specific specific JJ cord-001397-nrq4ncdf 728 14 neutralizing neutralize VBG cord-001397-nrq4ncdf 728 15 antibodies antibody NNS cord-001397-nrq4ncdf 728 16 against against IN cord-001397-nrq4ncdf 728 17 domain domain NN cord-001397-nrq4ncdf 728 18 III iii CD cord-001397-nrq4ncdf 728 19 of of IN cord-001397-nrq4ncdf 728 20 dengue dengue NN cord-001397-nrq4ncdf 728 21 virus virus NN cord-001397-nrq4ncdf 728 22 type type NN cord-001397-nrq4ncdf 728 23 2 2 CD cord-001397-nrq4ncdf 728 24 envelope envelope NN cord-001397-nrq4ncdf 728 25 protein protein NN cord-001397-nrq4ncdf 728 26 recognize recognize VBP cord-001397-nrq4ncdf 728 27 adjacent adjacent JJ cord-001397-nrq4ncdf 728 28 epitopes epitope NNS cord-001397-nrq4ncdf 729 1 Antiplatelet Antiplatelet NNP cord-001397-nrq4ncdf 729 2 autoantibodies autoantibody NNS cord-001397-nrq4ncdf 729 3 elicited elicit VBN cord-001397-nrq4ncdf 729 4 by by IN cord-001397-nrq4ncdf 729 5 dengue dengue NN cord-001397-nrq4ncdf 729 6 virus virus NN cord-001397-nrq4ncdf 729 7 non non JJ cord-001397-nrq4ncdf 729 8 - - JJ cord-001397-nrq4ncdf 729 9 structural structural JJ cord-001397-nrq4ncdf 729 10 protein protein NN cord-001397-nrq4ncdf 729 11 1 1 CD cord-001397-nrq4ncdf 729 12 cause cause NN cord-001397-nrq4ncdf 729 13 thrombocytopenia thrombocytopenia NN cord-001397-nrq4ncdf 729 14 and and CC cord-001397-nrq4ncdf 729 15 mortality mortality NN cord-001397-nrq4ncdf 729 16 in in IN cord-001397-nrq4ncdf 729 17 mice mouse NNS cord-001397-nrq4ncdf 730 1 Electron electron NN cord-001397-nrq4ncdf 730 2 microscopic microscopic JJ cord-001397-nrq4ncdf 730 3 study study NN cord-001397-nrq4ncdf 730 4 of of IN cord-001397-nrq4ncdf 730 5 persistent persistent JJ cord-001397-nrq4ncdf 730 6 Dengue Dengue NNP cord-001397-nrq4ncdf 730 7 virus virus NN cord-001397-nrq4ncdf 730 8 infection infection NN cord-001397-nrq4ncdf 730 9 : : : cord-001397-nrq4ncdf 730 10 analysis analysis NN cord-001397-nrq4ncdf 730 11 using use VBG cord-001397-nrq4ncdf 730 12 a a DT cord-001397-nrq4ncdf 730 13 cell cell NN cord-001397-nrq4ncdf 730 14 line line NN cord-001397-nrq4ncdf 730 15 persistently persistently RB cord-001397-nrq4ncdf 730 16 infected infect VBN cord-001397-nrq4ncdf 730 17 with with IN cord-001397-nrq4ncdf 730 18 Dengue-2 Dengue-2 NNP cord-001397-nrq4ncdf 730 19 virus virus NN cord-001397-nrq4ncdf 730 20 Molecular molecular JJ cord-001397-nrq4ncdf 730 21 mechanisms mechanism NNS cord-001397-nrq4ncdf 730 22 of of IN cord-001397-nrq4ncdf 730 23 Coxsackievirus Coxsackievirus NNP cord-001397-nrq4ncdf 730 24 persistence persistence NN cord-001397-nrq4ncdf 730 25 in in IN cord-001397-nrq4ncdf 730 26 chronic chronic JJ cord-001397-nrq4ncdf 730 27 inflammatory inflammatory JJ cord-001397-nrq4ncdf 730 28 myopathy myopathy NN cord-001397-nrq4ncdf 731 1 : : : cord-001397-nrq4ncdf 731 2 viral viral JJ cord-001397-nrq4ncdf 731 3 RNA RNA NNP cord-001397-nrq4ncdf 731 4 persists persist VBZ cord-001397-nrq4ncdf 731 5 through through IN cord-001397-nrq4ncdf 731 6 formation formation NN cord-001397-nrq4ncdf 731 7 of of IN cord-001397-nrq4ncdf 731 8 a a DT cord-001397-nrq4ncdf 731 9 double double RB cord-001397-nrq4ncdf 731 10 - - HYPH cord-001397-nrq4ncdf 731 11 stranded strand VBN cord-001397-nrq4ncdf 731 12 complex complex NN cord-001397-nrq4ncdf 731 13 without without IN cord-001397-nrq4ncdf 731 14 associated associated JJ cord-001397-nrq4ncdf 731 15 genomic genomic JJ cord-001397-nrq4ncdf 731 16 mutations mutation NNS cord-001397-nrq4ncdf 731 17 or or CC cord-001397-nrq4ncdf 731 18 evolution evolution NN cord-001397-nrq4ncdf 731 19 TRIM79alpha trim79alpha NN cord-001397-nrq4ncdf 731 20 , , , cord-001397-nrq4ncdf 731 21 an an DT cord-001397-nrq4ncdf 731 22 interferon interferon NN cord-001397-nrq4ncdf 731 23 - - HYPH cord-001397-nrq4ncdf 731 24 stimulated stimulate VBN cord-001397-nrq4ncdf 731 25 gene gene NN cord-001397-nrq4ncdf 731 26 product product NN cord-001397-nrq4ncdf 731 27 , , , cord-001397-nrq4ncdf 731 28 restricts restrict VBZ cord-001397-nrq4ncdf 731 29 tick tick NN cord-001397-nrq4ncdf 731 30 - - HYPH cord-001397-nrq4ncdf 731 31 borne bear VBN cord-001397-nrq4ncdf 731 32 encephalitis encephalitis JJ cord-001397-nrq4ncdf 731 33 virus virus NN cord-001397-nrq4ncdf 731 34 replication replication NN cord-001397-nrq4ncdf 731 35 by by IN cord-001397-nrq4ncdf 731 36 degrading degrade VBG cord-001397-nrq4ncdf 731 37 the the DT cord-001397-nrq4ncdf 731 38 viral viral JJ cord-001397-nrq4ncdf 731 39 RNA rna NN cord-001397-nrq4ncdf 731 40 polymerase polymerase NN cord-001397-nrq4ncdf 731 41 Persistent persistent JJ cord-001397-nrq4ncdf 731 42 LCMV LCMV NNP cord-001397-nrq4ncdf 731 43 infection infection NN cord-001397-nrq4ncdf 731 44 is be VBZ cord-001397-nrq4ncdf 731 45 controlled control VBN cord-001397-nrq4ncdf 731 46 by by IN cord-001397-nrq4ncdf 731 47 blockade blockade NN cord-001397-nrq4ncdf 731 48 of of IN cord-001397-nrq4ncdf 731 49 type type NN cord-001397-nrq4ncdf 732 1 I -PRON- PRP cord-001397-nrq4ncdf 732 2 interferon interferon RB cord-001397-nrq4ncdf 732 3 signaling signal VBG cord-001397-nrq4ncdf 732 4 A a DT cord-001397-nrq4ncdf 732 5 new new JJ cord-001397-nrq4ncdf 732 6 tick tick NN cord-001397-nrq4ncdf 732 7 - - HYPH cord-001397-nrq4ncdf 732 8 borne bear VBN cord-001397-nrq4ncdf 732 9 encephalitis encephalitis RB cord-001397-nrq4ncdf 732 10 - - HYPH cord-001397-nrq4ncdf 732 11 like like JJ cord-001397-nrq4ncdf 732 12 virus virus NN cord-001397-nrq4ncdf 732 13 infecting infect VBG cord-001397-nrq4ncdf 732 14 New New NNP cord-001397-nrq4ncdf 732 15 England England NNP cord-001397-nrq4ncdf 732 16 deer deer NN cord-001397-nrq4ncdf 733 1 ticks tick NNS cord-001397-nrq4ncdf 733 2 Persistent Persistent NNP cord-001397-nrq4ncdf 733 3 West West NNP cord-001397-nrq4ncdf 733 4 Nile Nile NNP cord-001397-nrq4ncdf 733 5 virus virus NN cord-001397-nrq4ncdf 733 6 infection infection NN cord-001397-nrq4ncdf 733 7 in in IN cord-001397-nrq4ncdf 733 8 the the DT cord-001397-nrq4ncdf 733 9 golden golden JJ cord-001397-nrq4ncdf 733 10 hamster hamster NN cord-001397-nrq4ncdf 733 11 : : : cord-001397-nrq4ncdf 733 12 studies study NNS cord-001397-nrq4ncdf 733 13 on on IN cord-001397-nrq4ncdf 733 14 its -PRON- PRP$ cord-001397-nrq4ncdf 733 15 mechanism mechanism NN cord-001397-nrq4ncdf 733 16 and and CC cord-001397-nrq4ncdf 733 17 possible possible JJ cord-001397-nrq4ncdf 733 18 implications implication NNS cord-001397-nrq4ncdf 733 19 for for IN cord-001397-nrq4ncdf 733 20 other other JJ cord-001397-nrq4ncdf 733 21 flavivirus flavivirus JJ cord-001397-nrq4ncdf 733 22 infections infection NNS cord-001397-nrq4ncdf 734 1 Polypyrimidine polypyrimidine JJ cord-001397-nrq4ncdf 734 2 tract tract NN cord-001397-nrq4ncdf 734 3 - - HYPH cord-001397-nrq4ncdf 734 4 binding bind VBG cord-001397-nrq4ncdf 734 5 protein protein NN cord-001397-nrq4ncdf 734 6 ( ( -LRB- cord-001397-nrq4ncdf 734 7 PTB PTB NNP cord-001397-nrq4ncdf 734 8 ) ) -RRB- cord-001397-nrq4ncdf 734 9 inhibits inhibit VBZ cord-001397-nrq4ncdf 734 10 hepatitis hepatitis NN cord-001397-nrq4ncdf 734 11 C C NNP cord-001397-nrq4ncdf 734 12 virus virus NN cord-001397-nrq4ncdf 734 13 internal internal JJ cord-001397-nrq4ncdf 734 14 ribosome ribosome NN cord-001397-nrq4ncdf 734 15 entry entry NN cord-001397-nrq4ncdf 734 16 site site NN cord-001397-nrq4ncdf 734 17 ( ( -LRB- cord-001397-nrq4ncdf 734 18 HCV HCV NNP cord-001397-nrq4ncdf 734 19 IRES)-mediated IRES)-mediated NNP cord-001397-nrq4ncdf 734 20 translation translation NN cord-001397-nrq4ncdf 734 21 , , , cord-001397-nrq4ncdf 734 22 but but CC cord-001397-nrq4ncdf 734 23 does do VBZ cord-001397-nrq4ncdf 734 24 not not RB cord-001397-nrq4ncdf 734 25 affect affect VB cord-001397-nrq4ncdf 734 26 HCV HCV NNP cord-001397-nrq4ncdf 734 27 replication replication NN cord-001397-nrq4ncdf 734 28 Yellow Yellow NNP cord-001397-nrq4ncdf 734 29 fever fever NN cord-001397-nrq4ncdf 734 30 : : : cord-001397-nrq4ncdf 734 31 the the DT cord-001397-nrq4ncdf 734 32 recurring recur VBG cord-001397-nrq4ncdf 734 33 plague plague NN cord-001397-nrq4ncdf 734 34 Persistent persistent JJ cord-001397-nrq4ncdf 734 35 shedding shedding NN cord-001397-nrq4ncdf 734 36 of of IN cord-001397-nrq4ncdf 734 37 West West NNP cord-001397-nrq4ncdf 734 38 Nile Nile NNP cord-001397-nrq4ncdf 734 39 virus virus NN cord-001397-nrq4ncdf 734 40 in in IN cord-001397-nrq4ncdf 734 41 urine urine NN cord-001397-nrq4ncdf 734 42 of of IN cord-001397-nrq4ncdf 734 43 experimentally experimentally RB cord-001397-nrq4ncdf 734 44 infected infect VBN cord-001397-nrq4ncdf 734 45 hamsters hamster NNS cord-001397-nrq4ncdf 734 46 Replication replication NN cord-001397-nrq4ncdf 734 47 enhancer enhancer NN cord-001397-nrq4ncdf 734 48 elements element NNS cord-001397-nrq4ncdf 734 49 within within IN cord-001397-nrq4ncdf 734 50 the the DT cord-001397-nrq4ncdf 734 51 open open JJ cord-001397-nrq4ncdf 734 52 reading reading NN cord-001397-nrq4ncdf 734 53 frame frame NN cord-001397-nrq4ncdf 734 54 of of IN cord-001397-nrq4ncdf 734 55 tick tick NN cord-001397-nrq4ncdf 734 56 - - HYPH cord-001397-nrq4ncdf 734 57 borne bear VBN cord-001397-nrq4ncdf 734 58 encephalitis encephalitis JJ cord-001397-nrq4ncdf 734 59 virus virus NN cord-001397-nrq4ncdf 734 60 and and CC cord-001397-nrq4ncdf 734 61 their -PRON- PRP$ cord-001397-nrq4ncdf 734 62 evolution evolution NN cord-001397-nrq4ncdf 734 63 within within IN cord-001397-nrq4ncdf 734 64 the the DT cord-001397-nrq4ncdf 734 65 Flavivirus Flavivirus NNP cord-001397-nrq4ncdf 734 66 genus genus NN cord-001397-nrq4ncdf 734 67 Molecular molecular JJ cord-001397-nrq4ncdf 734 68 characterization characterization NN cord-001397-nrq4ncdf 734 69 of of IN cord-001397-nrq4ncdf 734 70 virus virus NN cord-001397-nrq4ncdf 734 71 - - HYPH cord-001397-nrq4ncdf 734 72 specific specific JJ cord-001397-nrq4ncdf 734 73 RNA RNA NNP cord-001397-nrq4ncdf 734 74 produced produce VBN cord-001397-nrq4ncdf 734 75 in in IN cord-001397-nrq4ncdf 734 76 the the DT cord-001397-nrq4ncdf 734 77 brains brain NNS cord-001397-nrq4ncdf 734 78 of of IN cord-001397-nrq4ncdf 734 79 flavivirus flavivirus JJ cord-001397-nrq4ncdf 734 80 - - HYPH cord-001397-nrq4ncdf 734 81 susceptible susceptible JJ cord-001397-nrq4ncdf 734 82 and and CC cord-001397-nrq4ncdf 734 83 -resistant -resistant JJ cord-001397-nrq4ncdf 734 84 mice mouse NNS cord-001397-nrq4ncdf 734 85 after after IN cord-001397-nrq4ncdf 734 86 challenge challenge NN cord-001397-nrq4ncdf 734 87 with with IN cord-001397-nrq4ncdf 734 88 Murray Murray NNP cord-001397-nrq4ncdf 734 89 Valley Valley NNP cord-001397-nrq4ncdf 734 90 encephalitis encephalitis NN cord-001397-nrq4ncdf 734 91 virus virus NN cord-001397-nrq4ncdf 734 92 Clinical clinical JJ cord-001397-nrq4ncdf 734 93 and and CC cord-001397-nrq4ncdf 734 94 epidemiological epidemiological JJ cord-001397-nrq4ncdf 734 95 features feature NNS cord-001397-nrq4ncdf 734 96 of of IN cord-001397-nrq4ncdf 734 97 tick tick NN cord-001397-nrq4ncdf 734 98 - - HYPH cord-001397-nrq4ncdf 734 99 borne bear VBN cord-001397-nrq4ncdf 734 100 encephalitis encephalitis RB cord-001397-nrq4ncdf 734 101 in in IN cord-001397-nrq4ncdf 734 102 Perm perm NN cord-001397-nrq4ncdf 734 103 region region NN cord-001397-nrq4ncdf 734 104 Ecology ecology NN cord-001397-nrq4ncdf 734 105 and and CC cord-001397-nrq4ncdf 734 106 geographical geographical JJ cord-001397-nrq4ncdf 734 107 expansion expansion NN cord-001397-nrq4ncdf 734 108 of of IN cord-001397-nrq4ncdf 734 109 Japanese japanese JJ cord-001397-nrq4ncdf 734 110 encephalitis encephalitis RB cord-001397-nrq4ncdf 734 111 virus virus NN cord-001397-nrq4ncdf 734 112 Neurologic neurologic JJ cord-001397-nrq4ncdf 734 113 sequelae sequela NNS cord-001397-nrq4ncdf 734 114 of of IN cord-001397-nrq4ncdf 734 115 West West NNP cord-001397-nrq4ncdf 734 116 Nile Nile NNP cord-001397-nrq4ncdf 734 117 virus virus NN cord-001397-nrq4ncdf 734 118 infection infection NN cord-001397-nrq4ncdf 734 119 Encephalitis encephalitis RB cord-001397-nrq4ncdf 734 120 in in IN cord-001397-nrq4ncdf 734 121 the the DT cord-001397-nrq4ncdf 734 122 clinical clinical JJ cord-001397-nrq4ncdf 734 123 spectrum spectrum NN cord-001397-nrq4ncdf 734 124 of of IN cord-001397-nrq4ncdf 734 125 dengue dengue NN cord-001397-nrq4ncdf 734 126 infection infection NN cord-001397-nrq4ncdf 735 1 The the DT cord-001397-nrq4ncdf 735 2 transmission transmission NN cord-001397-nrq4ncdf 735 3 of of IN cord-001397-nrq4ncdf 735 4 the the DT cord-001397-nrq4ncdf 735 5 tick tick NN cord-001397-nrq4ncdf 735 6 - - HYPH cord-001397-nrq4ncdf 735 7 borne bear VBN cord-001397-nrq4ncdf 735 8 encephalitis encephalitis JJ cord-001397-nrq4ncdf 735 9 virus virus NN cord-001397-nrq4ncdf 735 10 via via IN cord-001397-nrq4ncdf 735 11 cow cow NN cord-001397-nrq4ncdf 735 12 's 's POS cord-001397-nrq4ncdf 735 13 milk milk NN cord-001397-nrq4ncdf 735 14 Genome genome NN cord-001397-nrq4ncdf 735 15 cyclization cyclization NN cord-001397-nrq4ncdf 735 16 as as IN cord-001397-nrq4ncdf 735 17 strategy strategy NN cord-001397-nrq4ncdf 735 18 for for IN cord-001397-nrq4ncdf 735 19 flavivirus flavivirus NNP cord-001397-nrq4ncdf 735 20 RNA RNA NNP cord-001397-nrq4ncdf 735 21 replication replication NN cord-001397-nrq4ncdf 735 22 Old Old NNP cord-001397-nrq4ncdf 735 23 World World NNP cord-001397-nrq4ncdf 735 24 hantaviruses hantaviruse NNS cord-001397-nrq4ncdf 735 25 do do VBP cord-001397-nrq4ncdf 735 26 not not RB cord-001397-nrq4ncdf 735 27 produce produce VB cord-001397-nrq4ncdf 735 28 detectable detectable JJ cord-001397-nrq4ncdf 735 29 amounts amount NNS cord-001397-nrq4ncdf 735 30 of of IN cord-001397-nrq4ncdf 735 31 dsRNA dsrna NN cord-001397-nrq4ncdf 735 32 in in IN cord-001397-nrq4ncdf 735 33 infected infected JJ cord-001397-nrq4ncdf 735 34 cells cell NNS cord-001397-nrq4ncdf 735 35 and and CC cord-001397-nrq4ncdf 735 36 the the DT cord-001397-nrq4ncdf 735 37 5 5 CD cord-001397-nrq4ncdf 735 38 0 0 CD cord-001397-nrq4ncdf 735 39 termini terminus NNS cord-001397-nrq4ncdf 735 40 of of IN cord-001397-nrq4ncdf 735 41 their -PRON- PRP$ cord-001397-nrq4ncdf 735 42 genomic genomic JJ cord-001397-nrq4ncdf 735 43 RNAs rna NNS cord-001397-nrq4ncdf 736 1 are be VBP cord-001397-nrq4ncdf 736 2 monophosphorylated monophosphorylate VBN cord-001397-nrq4ncdf 736 3 Relation Relation NNP cord-001397-nrq4ncdf 736 4 of of IN cord-001397-nrq4ncdf 736 5 genetic genetic JJ cord-001397-nrq4ncdf 736 6 phylogeny phylogeny NN cord-001397-nrq4ncdf 736 7 and and CC cord-001397-nrq4ncdf 736 8 geographical geographical JJ cord-001397-nrq4ncdf 736 9 distance distance NN cord-001397-nrq4ncdf 736 10 of of IN cord-001397-nrq4ncdf 736 11 tick tick NN cord-001397-nrq4ncdf 736 12 - - HYPH cord-001397-nrq4ncdf 736 13 borne bear VBN cord-001397-nrq4ncdf 736 14 encephalitis encephalitis JJ cord-001397-nrq4ncdf 736 15 virus virus NN cord-001397-nrq4ncdf 736 16 in in IN cord-001397-nrq4ncdf 736 17 central central JJ cord-001397-nrq4ncdf 736 18 Europe Europe NNP cord-001397-nrq4ncdf 736 19 Composition Composition NNP cord-001397-nrq4ncdf 736 20 and and CC cord-001397-nrq4ncdf 736 21 three three CD cord-001397-nrq4ncdf 736 22 - - HYPH cord-001397-nrq4ncdf 736 23 dimensional dimensional JJ cord-001397-nrq4ncdf 736 24 architecture architecture NN cord-001397-nrq4ncdf 736 25 of of IN cord-001397-nrq4ncdf 736 26 the the DT cord-001397-nrq4ncdf 736 27 dengue dengue NN cord-001397-nrq4ncdf 736 28 virus virus NN cord-001397-nrq4ncdf 736 29 replication replication NN cord-001397-nrq4ncdf 736 30 and and CC cord-001397-nrq4ncdf 736 31 assembly assembly NN cord-001397-nrq4ncdf 736 32 sites site NNS cord-001397-nrq4ncdf 736 33 Tick tick NN cord-001397-nrq4ncdf 736 34 - - HYPH cord-001397-nrq4ncdf 736 35 borne bear VBN cord-001397-nrq4ncdf 736 36 encephalitis encephalitis JJ cord-001397-nrq4ncdf 736 37 virus virus NN cord-001397-nrq4ncdf 736 38 NS5 ns5 JJ cord-001397-nrq4ncdf 736 39 associates associate NNS cord-001397-nrq4ncdf 736 40 with with IN cord-001397-nrq4ncdf 736 41 membrane membrane NN cord-001397-nrq4ncdf 736 42 protein protein NN cord-001397-nrq4ncdf 736 43 scribble scribble NN cord-001397-nrq4ncdf 736 44 and and CC cord-001397-nrq4ncdf 736 45 impairs impair VBZ cord-001397-nrq4ncdf 736 46 interferon interferon NN cord-001397-nrq4ncdf 736 47 - - HYPH cord-001397-nrq4ncdf 736 48 stimulated stimulate VBN cord-001397-nrq4ncdf 736 49 JAK JAK NNP cord-001397-nrq4ncdf 736 50 - - HYPH cord-001397-nrq4ncdf 736 51 STAT STAT NNP cord-001397-nrq4ncdf 736 52 signalling signal VBG cord-001397-nrq4ncdf 736 53 Ultrastructure Ultrastructure NNP cord-001397-nrq4ncdf 736 54 of of IN cord-001397-nrq4ncdf 736 55 Kunjin Kunjin NNP cord-001397-nrq4ncdf 736 56 virus virus NN cord-001397-nrq4ncdf 736 57 - - HYPH cord-001397-nrq4ncdf 736 58 infected infect VBN cord-001397-nrq4ncdf 736 59 cells cell NNS cord-001397-nrq4ncdf 736 60 : : : cord-001397-nrq4ncdf 736 61 colocalization colocalization NN cord-001397-nrq4ncdf 736 62 of of IN cord-001397-nrq4ncdf 736 63 NS1 ns1 NN cord-001397-nrq4ncdf 736 64 and and CC cord-001397-nrq4ncdf 736 65 NS3 ns3 RB cord-001397-nrq4ncdf 736 66 with with IN cord-001397-nrq4ncdf 736 67 double double RB cord-001397-nrq4ncdf 736 68 - - HYPH cord-001397-nrq4ncdf 736 69 stranded strand VBN cord-001397-nrq4ncdf 736 70 RNA RNA NNP cord-001397-nrq4ncdf 736 71 , , , cord-001397-nrq4ncdf 736 72 and and CC cord-001397-nrq4ncdf 736 73 of of IN cord-001397-nrq4ncdf 736 74 NS2B NS2B NNP cord-001397-nrq4ncdf 736 75 with with IN cord-001397-nrq4ncdf 736 76 NS3 ns3 RB cord-001397-nrq4ncdf 736 77 , , , cord-001397-nrq4ncdf 736 78 in in IN cord-001397-nrq4ncdf 736 79 virus virus NN cord-001397-nrq4ncdf 736 80 - - HYPH cord-001397-nrq4ncdf 736 81 induced induce VBN cord-001397-nrq4ncdf 736 82 membrane membrane NN cord-001397-nrq4ncdf 736 83 structures structure NNS cord-001397-nrq4ncdf 736 84 Kunjin Kunjin NNP cord-001397-nrq4ncdf 736 85 RNA RNA NNP cord-001397-nrq4ncdf 736 86 replication replication NN cord-001397-nrq4ncdf 736 87 and and CC cord-001397-nrq4ncdf 736 88 applications application NNS cord-001397-nrq4ncdf 736 89 of of IN cord-001397-nrq4ncdf 736 90 Kunjin Kunjin NNP cord-001397-nrq4ncdf 736 91 replicons replicon NNS cord-001397-nrq4ncdf 736 92 Detection Detection NNP cord-001397-nrq4ncdf 736 93 of of IN cord-001397-nrq4ncdf 736 94 persistent persistent JJ cord-001397-nrq4ncdf 736 95 West West NNP cord-001397-nrq4ncdf 736 96 Nile Nile NNP cord-001397-nrq4ncdf 736 97 virus virus NN cord-001397-nrq4ncdf 736 98 RNA RNA NNP cord-001397-nrq4ncdf 736 99 in in IN cord-001397-nrq4ncdf 736 100 experimentally experimentally RB cord-001397-nrq4ncdf 736 101 and and CC cord-001397-nrq4ncdf 736 102 naturally naturally RB cord-001397-nrq4ncdf 736 103 Infected infect VBN cord-001397-nrq4ncdf 736 104 avian avian JJ cord-001397-nrq4ncdf 736 105 hosts host NNS cord-001397-nrq4ncdf 736 106 St St NNP cord-001397-nrq4ncdf 736 107 Louis Louis NNP cord-001397-nrq4ncdf 736 108 encephalitis encephalitis RB cord-001397-nrq4ncdf 736 109 virus virus NN cord-001397-nrq4ncdf 736 110 : : : cord-001397-nrq4ncdf 736 111 an an DT cord-001397-nrq4ncdf 736 112 ultrastructural ultrastructural JJ cord-001397-nrq4ncdf 736 113 study study NN cord-001397-nrq4ncdf 736 114 of of IN cord-001397-nrq4ncdf 736 115 infection infection NN cord-001397-nrq4ncdf 736 116 in in IN cord-001397-nrq4ncdf 736 117 a a DT cord-001397-nrq4ncdf 736 118 mosquito mosquito NN cord-001397-nrq4ncdf 736 119 vector vector NN cord-001397-nrq4ncdf 736 120 West West NNP cord-001397-nrq4ncdf 736 121 Nile Nile NNP cord-001397-nrq4ncdf 736 122 virus virus NN cord-001397-nrq4ncdf 736 123 infection infection NN cord-001397-nrq4ncdf 736 124 in in IN cord-001397-nrq4ncdf 736 125 the the DT cord-001397-nrq4ncdf 736 126 golden golden JJ cord-001397-nrq4ncdf 736 127 hamster hamster NN cord-001397-nrq4ncdf 736 128 ( ( -LRB- cord-001397-nrq4ncdf 736 129 Mesocricetus Mesocricetus NNP cord-001397-nrq4ncdf 736 130 auratus auratus NN cord-001397-nrq4ncdf 736 131 ) ) -RRB- cord-001397-nrq4ncdf 736 132 : : : cord-001397-nrq4ncdf 736 133 a a DT cord-001397-nrq4ncdf 736 134 model model NN cord-001397-nrq4ncdf 736 135 for for IN cord-001397-nrq4ncdf 736 136 West West NNP cord-001397-nrq4ncdf 736 137 Nile Nile NNP cord-001397-nrq4ncdf 736 138 encephalitis encephalitis NN cord-001397-nrq4ncdf 736 139 Induction induction NN cord-001397-nrq4ncdf 736 140 of of IN cord-001397-nrq4ncdf 736 141 inflammation inflammation NN cord-001397-nrq4ncdf 736 142 by by IN cord-001397-nrq4ncdf 736 143 West West NNP cord-001397-nrq4ncdf 736 144 Nile Nile NNP cord-001397-nrq4ncdf 736 145 virus virus NN cord-001397-nrq4ncdf 736 146 capsid capsid NN cord-001397-nrq4ncdf 736 147 through through IN cord-001397-nrq4ncdf 736 148 the the DT cord-001397-nrq4ncdf 736 149 caspase-9 caspase-9 NNP cord-001397-nrq4ncdf 736 150 apoptotic apoptotic JJ cord-001397-nrq4ncdf 736 151 pathway pathway NN cord-001397-nrq4ncdf 736 152 West West NNP cord-001397-nrq4ncdf 736 153 Nile Nile NNP cord-001397-nrq4ncdf 736 154 virus virus NN cord-001397-nrq4ncdf 736 155 capsid capsid NN cord-001397-nrq4ncdf 736 156 protein protein NN cord-001397-nrq4ncdf 737 1 induces induce VBZ cord-001397-nrq4ncdf 737 2 p53-mediated p53-mediated JJ cord-001397-nrq4ncdf 737 3 apoptosis apoptosis NN cord-001397-nrq4ncdf 737 4 via via IN cord-001397-nrq4ncdf 737 5 the the DT cord-001397-nrq4ncdf 737 6 sequestration sequestration NN cord-001397-nrq4ncdf 737 7 of of IN cord-001397-nrq4ncdf 737 8 HDM2 HDM2 NNP cord-001397-nrq4ncdf 737 9 to to IN cord-001397-nrq4ncdf 737 10 the the DT cord-001397-nrq4ncdf 737 11 nucleolus nucleolus NN cord-001397-nrq4ncdf 737 12 Japanese japanese JJ cord-001397-nrq4ncdf 737 13 encephalitis encephalitis RB cord-001397-nrq4ncdf 737 14 virus virus NN cord-001397-nrq4ncdf 737 15 NS2B NS2B NNP cord-001397-nrq4ncdf 737 16 - - : cord-001397-nrq4ncdf 737 17 NS3 ns3 RB cord-001397-nrq4ncdf 737 18 protease protease NN cord-001397-nrq4ncdf 737 19 induces induce VBZ cord-001397-nrq4ncdf 737 20 caspase caspase NN cord-001397-nrq4ncdf 737 21 3 3 CD cord-001397-nrq4ncdf 737 22 activation activation NN cord-001397-nrq4ncdf 737 23 and and CC cord-001397-nrq4ncdf 737 24 mitochondria mitochondrion NNS cord-001397-nrq4ncdf 737 25 - - HYPH cord-001397-nrq4ncdf 737 26 mediated mediate VBN cord-001397-nrq4ncdf 737 27 apoptosis apoptosis NN cord-001397-nrq4ncdf 737 28 in in IN cord-001397-nrq4ncdf 737 29 human human JJ cord-001397-nrq4ncdf 737 30 medulloblastoma medulloblastoma NNP cord-001397-nrq4ncdf 737 31 cells cell NNS cord-001397-nrq4ncdf 737 32 Crystal Crystal NNP cord-001397-nrq4ncdf 737 33 structure structure NN cord-001397-nrq4ncdf 737 34 of of IN cord-001397-nrq4ncdf 737 35 the the DT cord-001397-nrq4ncdf 737 36 dengue dengue NN cord-001397-nrq4ncdf 737 37 virus virus NN cord-001397-nrq4ncdf 737 38 RNA rna NN cord-001397-nrq4ncdf 737 39 - - HYPH cord-001397-nrq4ncdf 737 40 dependent dependent JJ cord-001397-nrq4ncdf 737 41 RNA RNA NNP cord-001397-nrq4ncdf 737 42 polymerase polymerase NN cord-001397-nrq4ncdf 737 43 catalytic catalytic JJ cord-001397-nrq4ncdf 737 44 domain domain NN cord-001397-nrq4ncdf 737 45 at at IN cord-001397-nrq4ncdf 737 46 185-angstrom 185-angstrom CD cord-001397-nrq4ncdf 737 47 resolution resolution NN cord-001397-nrq4ncdf 737 48 Immune immune JJ cord-001397-nrq4ncdf 737 49 evasion evasion NN cord-001397-nrq4ncdf 737 50 strategies strategy NNS cord-001397-nrq4ncdf 737 51 of of IN cord-001397-nrq4ncdf 737 52 flaviviruses flavivirus NNS cord-001397-nrq4ncdf 738 1 The the DT cord-001397-nrq4ncdf 738 2 NS3 ns3 RB cord-001397-nrq4ncdf 738 3 protease protease NN cord-001397-nrq4ncdf 738 4 and and CC cord-001397-nrq4ncdf 738 5 helicase helicase NN cord-001397-nrq4ncdf 738 6 domains domain NNS cord-001397-nrq4ncdf 738 7 of of IN cord-001397-nrq4ncdf 738 8 Japanese japanese JJ cord-001397-nrq4ncdf 738 9 encephalitis encephalitis RB cord-001397-nrq4ncdf 738 10 virus virus NN cord-001397-nrq4ncdf 738 11 trigger trigger NN cord-001397-nrq4ncdf 738 12 cell cell NN cord-001397-nrq4ncdf 738 13 death death NN cord-001397-nrq4ncdf 738 14 via via IN cord-001397-nrq4ncdf 738 15 caspase caspase NN cord-001397-nrq4ncdf 738 16 dependent dependent JJ cord-001397-nrq4ncdf 738 17 and and CC cord-001397-nrq4ncdf 738 18 independent independent JJ cord-001397-nrq4ncdf 738 19 pathways pathway NNS cord-001397-nrq4ncdf 738 20 Structures structure NNS cord-001397-nrq4ncdf 738 21 of of IN cord-001397-nrq4ncdf 738 22 immature immature JJ cord-001397-nrq4ncdf 738 23 flavivirus flavivirus NNP cord-001397-nrq4ncdf 738 24 particles particle NNS cord-001397-nrq4ncdf 738 25 West West NNP cord-001397-nrq4ncdf 738 26 Nile Nile NNP cord-001397-nrq4ncdf 738 27 virus virus NN cord-001397-nrq4ncdf 738 28 genome genome NN cord-001397-nrq4ncdf 738 29 cyclization cyclization NN cord-001397-nrq4ncdf 738 30 and and CC cord-001397-nrq4ncdf 738 31 RNA RNA NNP cord-001397-nrq4ncdf 738 32 replication replication NN cord-001397-nrq4ncdf 738 33 require require VBP cord-001397-nrq4ncdf 738 34 two two CD cord-001397-nrq4ncdf 738 35 pairs pair NNS cord-001397-nrq4ncdf 738 36 of of IN cord-001397-nrq4ncdf 738 37 long long JJ cord-001397-nrq4ncdf 738 38 - - HYPH cord-001397-nrq4ncdf 738 39 distance distance NN cord-001397-nrq4ncdf 738 40 RNA RNA NNP cord-001397-nrq4ncdf 738 41 interactions interaction NNS cord-001397-nrq4ncdf 738 42 Japanese japanese JJ cord-001397-nrq4ncdf 738 43 encephalitis encephalitis RB cord-001397-nrq4ncdf 738 44 virus virus NN cord-001397-nrq4ncdf 738 45 RNA RNA NNP cord-001397-nrq4ncdf 738 46 not not RB cord-001397-nrq4ncdf 738 47 detected detect VBN cord-001397-nrq4ncdf 738 48 in in IN cord-001397-nrq4ncdf 738 49 urine urine NN cord-001397-nrq4ncdf 738 50 The the DT cord-001397-nrq4ncdf 738 51 persistence persistence NN cord-001397-nrq4ncdf 738 52 of of IN cord-001397-nrq4ncdf 738 53 louping loupe VBG cord-001397-nrq4ncdf 738 54 ill ill JJ cord-001397-nrq4ncdf 738 55 virus virus NN cord-001397-nrq4ncdf 738 56 in in IN cord-001397-nrq4ncdf 738 57 immunosuppressed immunosuppressed JJ cord-001397-nrq4ncdf 738 58 guinea guinea NN cord-001397-nrq4ncdf 738 59 - - HYPH cord-001397-nrq4ncdf 738 60 pigs pig NNS cord-001397-nrq4ncdf 739 1 A a DT cord-001397-nrq4ncdf 739 2 single single JJ cord-001397-nrq4ncdf 739 3 - - HYPH cord-001397-nrq4ncdf 739 4 amino amino NN cord-001397-nrq4ncdf 739 5 acid acid NN cord-001397-nrq4ncdf 739 6 substitution substitution NN cord-001397-nrq4ncdf 739 7 in in IN cord-001397-nrq4ncdf 739 8 West West NNP cord-001397-nrq4ncdf 739 9 Nile Nile NNP cord-001397-nrq4ncdf 739 10 virus virus NN cord-001397-nrq4ncdf 739 11 2 2 CD cord-001397-nrq4ncdf 739 12 K k NN cord-001397-nrq4ncdf 739 13 peptide peptide NN cord-001397-nrq4ncdf 739 14 between between IN cord-001397-nrq4ncdf 739 15 NS4A NS4A NNP cord-001397-nrq4ncdf 739 16 and and CC cord-001397-nrq4ncdf 739 17 NS4B NS4B NNP cord-001397-nrq4ncdf 739 18 confers confer VBZ cord-001397-nrq4ncdf 739 19 resistance resistance NN cord-001397-nrq4ncdf 739 20 to to IN cord-001397-nrq4ncdf 739 21 lycorine lycorine NNP cord-001397-nrq4ncdf 739 22 , , , cord-001397-nrq4ncdf 739 23 a a DT cord-001397-nrq4ncdf 739 24 flavivirus flavivirus JJ cord-001397-nrq4ncdf 739 25 inhibitor inhibitor NN cord-001397-nrq4ncdf 739 26 This this DT cord-001397-nrq4ncdf 739 27 work work NN cord-001397-nrq4ncdf 739 28 was be VBD cord-001397-nrq4ncdf 739 29 supported support VBN cord-001397-nrq4ncdf 739 30 by by IN cord-001397-nrq4ncdf 739 31 the the DT cord-001397-nrq4ncdf 739 32 Intramural Intramural NNP cord-001397-nrq4ncdf 739 33 Research Research NNP cord-001397-nrq4ncdf 739 34 Program Program NNP cord-001397-nrq4ncdf 739 35 , , , cord-001397-nrq4ncdf 739 36 National National NNP cord-001397-nrq4ncdf 739 37 Institute Institute NNP cord-001397-nrq4ncdf 739 38 of of IN cord-001397-nrq4ncdf 739 39 Allergy Allergy NNP cord-001397-nrq4ncdf 739 40 and and CC cord-001397-nrq4ncdf 739 41 Infectious Infectious NNP cord-001397-nrq4ncdf 739 42 Diseases Diseases NNPS cord-001397-nrq4ncdf 739 43 , , , cord-001397-nrq4ncdf 739 44 National National NNP cord-001397-nrq4ncdf 739 45 Institutes Institutes NNPS cord-001397-nrq4ncdf 739 46 of of IN cord-001397-nrq4ncdf 739 47 Health Health NNP cord-001397-nrq4ncdf 739 48 ( ( -LRB- cord-001397-nrq4ncdf 739 49 NIH NIH NNP cord-001397-nrq4ncdf 739 50 ) ) -RRB- cord-001397-nrq4ncdf 739 51 . . . cord-001397-nrq4ncdf 740 1 We -PRON- PRP cord-001397-nrq4ncdf 740 2 wish wish VBP cord-001397-nrq4ncdf 740 3 to to TO cord-001397-nrq4ncdf 740 4 acknowledge acknowledge VB cord-001397-nrq4ncdf 740 5 the the DT cord-001397-nrq4ncdf 740 6 able able JJ cord-001397-nrq4ncdf 740 7 assistance assistance NN cord-001397-nrq4ncdf 740 8 of of IN cord-001397-nrq4ncdf 740 9 Anita Anita NNP cord-001397-nrq4ncdf 740 10 Mora Mora NNP cord-001397-nrq4ncdf 740 11 and and CC cord-001397-nrq4ncdf 740 12 Heather Heather NNP cord-001397-nrq4ncdf 740 13 Murphy Murphy NNP cord-001397-nrq4ncdf 740 14 for for IN cord-001397-nrq4ncdf 740 15 graphic graphic JJ cord-001397-nrq4ncdf 740 16 support support NN cord-001397-nrq4ncdf 740 17 . . . cord-001397-nrq4ncdf 741 1 Danielle Danielle NNP cord-001397-nrq4ncdf 741 2 Offerdahl Offerdahl NNP cord-001397-nrq4ncdf 741 3 and and CC cord-001397-nrq4ncdf 741 4 Jennifer Jennifer NNP cord-001397-nrq4ncdf 741 5 Lam Lam NNP cord-001397-nrq4ncdf 741 6 provided provide VBD cord-001397-nrq4ncdf 741 7 assistance assistance NN cord-001397-nrq4ncdf 741 8 in in IN cord-001397-nrq4ncdf 741 9 manuscript manuscript NN cord-001397-nrq4ncdf 741 10 preparation preparation NN cord-001397-nrq4ncdf 741 11 . . .