id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-354931-0bwf8f1i	Song, Jae-Hyoung	Antiviral and Anti-Inflammatory Activities of Pochonin D, a Heat Shock Protein 90 Inhibitor, against Rhinovirus Infection	2018-05-02		.txt	text/plain	4907	279	47	In the current study, we examined the effect of the Hsp90 inhibitor pochonin D, in vitro and in vivo, using a murine model of human rhinovirus type 1B (HRV1B) infection. We therefore decided to monitor the lung cytokine levels and virus titers at 8 h after HRV1B infection for evaluating the antiviral activity of pochonin D in mice. Real-time PCR analysis of viral mRNA in lung tissues revealed that the virus titer was significantly reduced in pochonin D-treated mice compared to that of vehicle-treated mice after HRV1B infection ( Fig. 2A) . A few changes in the total cell numbers in the lung and BALF were observed after treatment of HRV1B-infected mice with pochonin D (Supplementary Fig. 3) . We found that treatment with pochonin D lowered the level of pro-inflammatory cytokines in the lung and BALF of mice, which were increased by rhinovirus infection.	./cache/cord-354931-0bwf8f1i.txt	./txt/cord-354931-0bwf8f1i.txt