id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-347761-wgodcsav	Cant, Andrew	Infections in the Immunocompromised	2009-10-24		.txt	text/plain	5992	331	39	Pneumocystis jiroveci pneumonia (PCP), CMV and Aspergillus are particularly important and well recognized sources of infection in the immunocompromised host; however, other significant pathogens have more recently been identified. Lung biopsy may be particularly important in the diagnosis of fungal infection, especially when there is a negative BAL in patients with persistent signs, symptoms or chest x-ray changes. PCP has historically been associated with HIV but is also a significant cause of morbidity in other groups of immunocompromised patients, particularly those with haematological malignancies, brain tumours requiring prolonged courses of steroids, prolonged neutropaenia or lymphopaenia, and those undergoing HSCT. Prophylaxis to prevent CMV and HSV reactivation is used for children undergoing HSCT and many SOTs. Surveillance in high-risk patients enables pre-emptive treatment to be given before damaging disease occurs. Adenovirus is usually responsible for relatively minor upper respiratory tract or gastrointestinal infection but can result in life-threatening pneumonia, meningitis, encephalitis and disseminated disease in the immunocompromised.	./cache/cord-347761-wgodcsav.txt	./txt/cord-347761-wgodcsav.txt