id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-347246-0vofftmj	Everitt, J I	Infectious diseases of the upper respiratory tract: implications for toxicology studies.	1990-04-17		.txt	text/plain	3572	190	28	This paper reviews several important infectious diseases of the upper airway of rats and mice and discusses the potential influence of these conditions on the results of toxicology studies. All three agents cause significant rodent respiratory disease, with lesions in the upper airways, including the nasal passages. Although there are many excellent descriptive studies ofthe histogenesis of Sendai virus-induced lesions within the lower respiratory tract, few pathology reports include a description of lesions in the nasal cavity and upper airway. Although numerous bacteria can infect the upper airway of the rat and mouse, they are not generally prevalent in well-conducted toxicology studies begun with animals free of adventitious murine pathogens and maintained with modern methods of laboratory animal husbandry. A variety of important microbial pathogens including viruses, mycoplasmas, bacteria, and fungi infect the upper respiratory tract of the mouse and rat and result in significant pathologic alterations.	./cache/cord-347246-0vofftmj.txt	./txt/cord-347246-0vofftmj.txt