id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-347064-ljd121no	José, Ricardo J.	Opportunistic bacterial, viral and fungal infections of the lung	2016-05-05		.txt	text/plain	2952	159	29	Conventional bacterial pathogens Although the risk of opportunistic infection is high in immunocompromised patients, most pneumonias are related to the more Key points C Knowledge of the immune defect helps to narrow down the potential pathogens C Computed tomography of the chest is better than radiographs at defining the radiological pattern of disease in immunocompromised hosts C In selected patients, early bronchoscopy increases the yield of microbiological identification of a potential pathogen C Prolonged high-dose glucocorticoids (>20 mg/day for >21 days) predispose to Pneumocystis jirovecii pneumonia (PJP) C Biological agents are associated with specific immune defects that increase the risk of opportunistic lung infections (e.g. tumour necrosis factor-a inhibitors and risk of mycobacterial disease, endemic fungi and Legionella pneumophila; anti-CD20 drugs and mycobacterial disease, cytomegalovirus pneumonitis and PJP) C Due to the increase in azole resistance of Aspergillus fumigatus, combination of an azole with an echinocandin antifungal agent is recommended in immunocompromised hosts with severe invasive pulmonary aspergillosis conventional bacterial pathogens.	./cache/cord-347064-ljd121no.txt	./txt/cord-347064-ljd121no.txt