id author title date pages extension mime words sentences flesch summary cache txt cord-342464-6vk2oxo5 Edwards, Michael R. The microbiology of asthma 2012-06-06 .txt text/plain 8087 352 36 The hygiene hypothesis posits that repeated exposure to diverse common infections (in particular, with bacteria, food-borne and oro faecal parasites 4 , and hookworms 5 ) and exposure to environmental microbiota during childhood 6, 7 are strongly associated with a healthy maturation of the immune system and with protection from the development of asthma and allergies later in life 8, 9 . Case control studies show a clear link between respiratory virus infection together with allergen exposure in sensitized children 108 and adults 109 in increasing the risk of hospital admissions due to asthma exacerbations. 5. Excessive T H 2 type responses are implicated in the pathogenesis of RSV-mediated bronchiolitis 110 , and increased production of IL-5 by T cells at birth is associated with a greater risk of severe respiratory infection 111 . ./cache/cord-342464-6vk2oxo5.txt ./txt/cord-342464-6vk2oxo5.txt