id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-339328-wizu3arz	Jain, Sanjay K.	The Promise of Molecular Imaging in the Study and Treatment of Infectious Diseases	2017-02-02		.txt	text/plain	4249	212	35	Preclinical Unique insights into disease pathogenesis, e.g., assessing hideouts of infections, defining the diversity of the microbial populations (microbiome) Studying multi-compartment antimicrobial pharmacokinetics Expedite bench-to-bedside translation of new therapeutics, e.g., surrogate end points to assess antimicrobial or vaccine efficacy or predict stable cure Clinical trials Unique insights into disease pathogenesis-noninvasive visualization of processes deep inside the body Phase 0 studies to determine compartment-specific antimicrobial penetration/binding (sites of infection, necrotic/fibrotic lesions, privileged sites-CNS) to inform appropriate dosing of novel drugs; determine accumulation at non-target sites to assess potential toxicities; current US Food and Drug Administration (FDA) guidelines require tissue drug distribution studies at the infected sites Patient settings Enabling precision medicine by providing unique insights into disease pathogenesis, antimicrobial pharmacokinetics, etc.	./cache/cord-339328-wizu3arz.txt	./txt/cord-339328-wizu3arz.txt