id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-335614-qh98622y	Xu, Puzhi	A Multi-Omics Study of Chicken Infected by Nephropathogenic Infectious Bronchitis Virus	2019-11-16		.txt	text/plain	6543	352	41	These genes and metabolites were linked to NIBV-infection related processes, including immune response, signal transduction, peroxisome, purine, and amino acid metabolism. Taken together, our research comprehensively describes the host responses during NIBV infection and provides new clues for further dissection of specific gene functions, metabolite affections, and the role of gut microbiota during chicken gout. The results of PCA and OPLA-DA analysis showed that there was an obvious separation between the content of the Con and Dis groups, revealing significant changes in the concentrations of metabolites in the kidney induced by NIBV infection. In addition, the transcriptomic analysis showed that NIBV infection also activated the RIG-I-like receptor signalling pathway (Figure 3f , signal 2), which included the transcriptional upregulation of genes such as MDA5, IPS-1, TRAF3, and IκB. In the present study, the ABCG2 mRNA was downregulated in the model group chicken kidneys, partially explaining the significantly increased uric acid levels caused by NIBV infection.	./cache/cord-335614-qh98622y.txt	./txt/cord-335614-qh98622y.txt