id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-333355-ykmp4ven	Kuchar, E.	Pathophysiology of Clinical Symptoms in Acute Viral Respiratory Tract Infections	2015-03-19		.txt	text/plain	6665	370	46	In this article we discuss the pathophysiology of common symptoms of acute viral respiratory infections (e.g., sneezing, nasal discharge, sore throat, cough, muscle pains, malaise, and mood changes). The development of sneezing before coughing in patients with a common cold may be partly explained by the involvement of the upper airways first and the infection subsequent spread to the lower respiratory tract (Eccles 2005) . We focused on the most significant symptoms of acute viral respiratory infections: sneezing, nasal discharge and obstruction, sore throat, coughing, muscle pains, malaise and mood changes, fever, and febrile seizures in children. Macrophages play a key role in triggering an acute phase response with the production of cytokines (Beutler 2003) , while the release of proinflammatory cytokines and other mediators cause upper respiratory tract infection symptoms (Eccles 2000a, b) .	./cache/cord-333355-ykmp4ven.txt	./txt/cord-333355-ykmp4ven.txt