id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-328795-rs1sd42z	Falsey, Ann R.	Rhinoviruses	2016-10-24		.txt	text/plain	4511	222	45	The incidence of HRV infection in children during the first 2 years of life was noted to be 0.7-2 infections per year in older studies using cell culture for viral detection (Brownlee and Turner, 2008) . Although symptoms associated with 'the common cold' syndrome are often attributed to HRV disease, the clinical findings of rhinovirus infections are indistinguishable from those of other viral pathogens. Currently, there are no antiviral drugs approved for clinical use in HRV infections although a few agents have been advanced to clinical trials and shown modest results in decreasing either symptom severity or viral activity. Conversely, monoclonal antibody blockade of the ICAM-1 receptor, the site of cellular attachment for the majority of HRV-A and HRV-B serotypes, has also been studied and demonstrated a reduction in the severity of symptoms and viral shedding but failed to prevent infection in the rhinovirus challenge model (Greenberg, 2003) .	./cache/cord-328795-rs1sd42z.txt	./txt/cord-328795-rs1sd42z.txt