id author title date pages extension mime words sentences flesch summary cache txt cord-323311-xl2fv0qx Kahn, R. E. 6th International Conference on Emerging Zoonoses 2012-09-07 .txt text/plain 19161 802 41 The three key characteristics of this integrated approach to so many infectious diseases are as follows: (i) to use cell culture, primary cells, nonhuman primate and human clinical models to study viral infection; (ii) to combine traditional histopathological, virological and biochemical approaches with functional genomics, proteomics and computational biology (Haagmans et al., 2009); and (iii) to obtain signatures of virulence and insights into mechanisms of host defense response, viral evasion and pathogenesis (Casadevaill et al., 2011) . The unity of human, animal and ecosystem health outlined by Professor Aguirre, as well as the interactions among multiple tick-borne pathogens in a natural reservoir host set out by Professor Fish and his research team, both summarized in Topic 1 above, highlight the necessity of cross-disciplinary collaboration in studying zoonotic bacterial diseases (Daszak et al., 2007, pp. ./cache/cord-323311-xl2fv0qx.txt ./txt/cord-323311-xl2fv0qx.txt