id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-322380-udjoghr6	Nash, Anthony A.	Early Stages of Infection After Pathogen Entry	2015-02-06		.txt	text/plain	5781	258	45	In the basal layer of the epidermis, adjacent to the antibodies and immune cells that arrive from dermal blood vessels, the virus infection is incomplete; in this layer of the epidermis, only a subset of virus genes are transcribed, no virus structural proteins are produced and no virus DNA replication occurs, therefore no virus particles are produced. This means gaining access to the lumen of a subepithelial lymphatic or blood vessel, either as a free microorganism, or alternatively after entering a mobile cell (leucocyte) that will carry it to other parts of the body. Thus, rotaviruses and rhinoviruses replicate at the epithelial surface but cannot infect leucocytes, and in any case would be unlikely to find susceptible cells elsewhere in the body if they entered blood or lymphatic vessels. Indeed, bacteria and other microorganisms that are capable of extracellular replication generally advertise their presence by releasing a variety of products into surrounding fluids, many of which cause inflammation and thus bring antibacterial agents such as immunoglobulins, complement and leucocytes to the site of the infection.	./cache/cord-322380-udjoghr6.txt	./txt/cord-322380-udjoghr6.txt