id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-321481-vrfwczve	Watashi, Koichi	NTCP and Beyond: Opening the Door to Unveil Hepatitis B Virus Entry	2014-02-19		.txt	text/plain	4936	247	39	Recently, sodium taurocholate cotransporting polypeptide (NTCP) was identified as an HBV entry receptor and enabled the establishment of a susceptible cell line that can efficiently support HBV infection. HBV infection into host hepatocytes follows a multiple step process: (1) initially, HBV reversibly attaches to host cell surface proteoglycans with a low affinity; (2) this is followed by the process involving more specific receptor(s) with high affinity to mediate the early entry step; and (3) after endocytosis-mediated internalization, the virus fuses with the cellular membrane compartment, probably in an endosomal compartment, although the mechanisms are not fully understood. A myristoylated peptide encompassing amino acids 2-48 of the preS1 region turned out to be the most efficient in infection inhibition of HBV and also the envelope protein-related hepatitis D virus (HDV) [30, 31] . Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter NTCP	./cache/cord-321481-vrfwczve.txt	./txt/cord-321481-vrfwczve.txt