id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-317548-ft7lkpzq	Proud, David	Upper airway viral infections	2007-07-05		.txt	text/plain	4004	196	36	Despite the major health care consequences associated with these complications, our understanding of how URI trigger upper airway symptoms and cause exacerbations of lower airway diseases remains limited. Given that HRV is the major viral pathogen associated with colds and exacerbations of asthma and COPD, we will focus on the current status of our knowledge of the response to HRV infection as representative of viral pathogenesis, indicating differences with other viral types when appropriate. Several factors are likely to play a role in determining the severity of the clinical outcome to upper airway viral responses, including the susceptibility of patients with asthma or COPD to experience lower airway exacerbations. Influenza vaccine is clearly effective in reducing upper airway symptoms, and in preventing lower disease exacerbations, induced by this virus during the winter months. Nitric oxide inhibits rhinovirus-induced cytokine production and viral replication in a human respiratory epithelial cell line	./cache/cord-317548-ft7lkpzq.txt	./txt/cord-317548-ft7lkpzq.txt