id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-312438-zr9zx7pv	Hoo, Regina	Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface	2020-09-10		.txt	text/plain	7551	382	40	Here, we outline the anatomy of the human placenta and uterine lining, the decidua, and discuss the potential capacity of pathogen pattern recognition and other host defense strategies present in the innate immune cells at the placental-decidual interface. Pathogen recognition is not only an essential component of the innate immune response against infection, but also plays an important role in bridging the innate and adaptive systems by Toll-like receptors (TLR) activation of antigen presenting cells by up-regulation of major histocompatibility complex (MHC) and co-stimulatory molecules (75) . Current evidence is only limited to in vitro TLR2/4 stimulation studies using placental explants and primary first trimester trophoblast cells, which drives the expression of FIGURE 3 | Toll-like receptors and potential inflammatory response at the decidua. In the mouse model of ZIKV infection, type I IFN-mediated signaling is essential for the control of viral replication in the placenta, but can also lead to significant placental pathology and fetal mortality (116, 117) .	./cache/cord-312438-zr9zx7pv.txt	./txt/cord-312438-zr9zx7pv.txt