id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-307899-427a7i3h	BITTLE, JAMES L.	Vaccines Produced by Conventional Means to Control Major Infectious Diseases of Man and Animals	1989-12-31		.txt	text/plain	17476	1073	49	Adenoviruses cause significant disease in dogs, foxes, and man, but have also been isolated from cattle, swine, goats, sheep, horses, turkeys, and chickens, where they produce mild infections, mainly associated with the respiratory and intestinal tracts. The latter modified the virus by serial passage in porcine and canine tissue cultures; the resulting vaccine immunized dogs and did not produce clinical signs of infection except for occasional corneal opacity similar to that caused by natural infection. The immunity produced by the attenuated live-virus CAV-1 vaccines is long lasting and has drastically reduced the incidence of the canine disease. The exception is human hepatitis A virus, which causes a serious disease and has one serotype; the development of both inactivated virus and attenuated live-virus vaccines is in progress (Hilleman et al., 1982; Provost et al., 1983) . An attenuated live-virus yellow fever vaccine was developed by passage of the virulent Asibi strain in mouse brain and cell culture until it had lost its pathogenicity for monkeys and man (Theiler, 1951) .	./cache/cord-307899-427a7i3h.txt	./txt/cord-307899-427a7i3h.txt