id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-305890-mdwjrfzp	Bönsch, Claudia	Chloroquine and Its Derivatives Exacerbate B19V-Associated Anemia by Promoting Viral Replication	2010-04-27		.txt	text/plain	4118	230	50	The aims of this study were to assess the effect of CQ and other common antimalarial drugs on B19V infection in vitro and the possible epidemiological consequences for children from Papua New Guinea (PNG). METHODOLOGY/PRINCIPAL FINDINGS: Viral RNA, DNA and proteins were analyzed in different cell types following infection with B19V in the presence of a range of antimalarial drugs. Relationships between B19V infection status, prior 4-aminoquinoline use and anemia were assessed in 200 PNG children <10 years of age participating in a case-control study of severe infections. In addition, we examined the relationship between B19V infection and use of 4-aminoquinoline drugs in a sample of children from PNG who were hospitalized with severe anemia. The expression of structural viral proteins in extracts of infected UT7/Epo cells was also increased in the presence of 25 mM CQ ( Figure 1C ). Human parvovirus infection in children and severe anemia seen in an area endemic for malaria	./cache/cord-305890-mdwjrfzp.txt	./txt/cord-305890-mdwjrfzp.txt