id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304088-xkg0ylz8	Zhu, Han	Cardiovascular Complications in Patients with COVID-19: Consequences of Viral Toxicities and Host Immune Response	2020-04-21		.txt	text/plain	5532	236	38	While limited data exist, potential mechanisms of cardiac injury include direct viral entry through the angiotensin-converting enzyme 2 (ACE2) receptor and toxicity in host cells, hypoxia-related myocyte injury, and immune-mediated cytokine release syndrome. The increased incidence of cardiac injury among those with severe systemic inflammatory response syndromes (SIRS) and shock in the setting of COVID-19 also highlights an important relationship between the immune response to the virus and the cardiovascular system. Of note, SARS-CoV-2 also contains an RNA-dependent RNA polymerase which is the target of the anti-viral agent remdesivir, currently being studied randomized clinical trials for use against COVID-19 disease [26] . A recent retrospective, multi-center study of 150 patients confirmed that inflammatory markers, including elevated ferritin (mean 1297.6 ng/ml in non-survivors vs 614.0 ng/ml in survivors, p < 0.001) and IL-6 (p < 0.0001) were associated with more severe COVID-19 infection, suggesting that systemic inflammation may be a significant driver of multi-organ damage [18, 64] .	./cache/cord-304088-xkg0ylz8.txt	./txt/cord-304088-xkg0ylz8.txt