id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-301677-b6mnn27h	Soleimanian, Saeede	Harnessing Memory NK Cell to Protect Against COVID-19	2020-08-20		.txt	text/plain	9746	462	42	In this regard, Natural Killer (NK) cells as essential front-line responders to many viral infections in humans have been proposed for a suitable therapeutic approach in severe COVID-19 patients, and several clinical trials have begun (Market et al., 2020) . In this line, Type I IFNs have a critical role in concert with pattern PRR signaling to prime innate and adaptive antiviral responses such as stimulating natural killer (NK) cells, macrophages, and production of proinflammatory cytokines (Samuel, 2001; Murira and Lamarre, 2016) . The detection of both SARS-CoV-2 nucleic acid and specific antibodies to viral proteins have thus far become significant for primary diagnosis infection and immunity in COVID-19 patients, respectively. in a pneumonia model of SARS in mice, mimicking features of the human disease, illustrated that mice depleted of both CD4 and CD8T cells, had the ability to control SARS-CoV replication in the lungs, suggesting an immune mechanism independent of T cells, and a role for innate antiviral response and NK cells, in viral clearance.	./cache/cord-301677-b6mnn27h.txt	./txt/cord-301677-b6mnn27h.txt