id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-297790-tpjxt0w5	Mandl, Judith N.	Going to Bat(s) for Studies of Disease Tolerance	2018-09-20		.txt	text/plain	9486	393	40	Among them are filoviruses (e.g., Marburg, Ebola), coronaviruses (e.g., SARS, MERS), henipaviruses (e.g., Hendra, Nipah) which share the common features that they are all RNA viruses, and that a dysregulated immune response is an important contributor to the tissue damage and hence pathogenicity that results from infection in humans. It is likely that differences in evolutionary history of pathogen exposure between bats and humans have led to distinct adaptations in anti-viral immune responses and the ability to tolerate certain infections without disease while being susceptible to others. We summarize this work below, but comparisons of observations made across species suggest that although a number of species appear to be capable of avoiding the pathological effects of RNA virus infection, each bat species may have achieved this through distinct pathways, possibly involving changes to both increase pathogen replication control and to mitigate any immunopathology through decreased inflammatory responses and hence increased disease tolerance.	./cache/cord-297790-tpjxt0w5.txt	./txt/cord-297790-tpjxt0w5.txt