id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-289650-q2io8vgi	Hammond, Ffion R.	If it’s not one thing, HIF’s another: immunoregulation by hypoxia inducible factors in disease	2020-07-06		.txt	text/plain	3795	212	35	Hypoxia Inducible Factors (HIFs) are master transcriptional regulators of the cellular response to hypoxia, that have influential roles in innate immune cell behaviour during inflammation and infections [1] . All rights reserved HIF researchers were awarded the Nobel Prize in Physiology or Medicine in 2019 for their discoveries on the regulation of the cellular hypoxia response, with their medical research predominantly focusing on HIFs' potential role as a therapeutic target to combat anaemia, due to HIF's activating effect on red blood cell production [8] . During infection and inflammation, HIF-α is stabilised in immune cell populations, partially driven by the hypoxic tissue context of disease, alongside oxygen independent activation [10]. Promoting HIF-1α stabilisation with the hydroxylase inhibitor CoCl 2 promoted fungal death in vitro (human macrophages) and in vivo (mouse) indicating a therapeutic potential for HIF-1α manipulation in candida infection [55] .	./cache/cord-289650-q2io8vgi.txt	./txt/cord-289650-q2io8vgi.txt