id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-288113-ex4yi28u	Epalza, Cristina	Role of Viral Molecular Panels in Diagnosing the Etiology of Fever in Infants Younger Than 3 Months	2019-11-09		.txt	text/plain	3656	182	44	As infants with proven viral infection present lower risk of bacterial infection, we evaluated how molecular methods detecting viruses on respiratory secretions could contribute to etiological diagnostic of these febrile episodes. The management of febrile infants younger than 3 months in the emergency room (ER) is challenging as they have a higher risk of serious bacterial infection (SBI) than older children and because clinical evaluation has a low sensitivity and specificity in identifying those infants with SBI. The aims of this prospective study were to evaluate the analytical performances of a multiplex diagnostic tool detecting the most frequent respiratory viruses as compared with our set of homemade real-time PCRs and the potential contribution of these molecular methods to the etiologic diagnosis of febrile episodes in infants younger than 3 months of life. The present evaluation demonstrates that molecular techniques greatly improve the detection rate of viral infections, especially in the challenging group of febrile infants without clinical source, among which the increase in microbiological documentation was nearly 20%.	./cache/cord-288113-ex4yi28u.txt	./txt/cord-288113-ex4yi28u.txt