id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-283826-lgyc3sro	Stiehm, E. Richard	Therapeutic Use of Immunoglobulins	2010-11-05		.txt	text/plain	9752	562	37	medical science and thereby placed in the hands of the physician a victorious weapon against illness and death.' ' Since then antibodies in multiple forms (animal and human serums, immune globulins and monoclonal antibodies) have been developed, primarily for prevention of infectious diseases, and less commonly for their treatment. Thus regular use of IVIG in antibody-deficient patients in doses of 400 to 600 mg/kg every 3 to 4 weeks or an equivalent amount given subcutaneously decreases the frequency and severity of otitis and other respiratory tract infections [27, 28] . High-dose IVIG (sufficient to increase the serum IgG levels to 1000 mg/mL) has been used successfully in immunodeficient patients with enteroviral encephalomyelitis [80] [81] [82] [83] . Because IgG represents the major defense of humoral immunity against infection, these patients also require immunoglobulin replacement therapy. Individualizing the dose of intravenous immune serum globulin for therapy of patients with primary humoral immunodeficiency	./cache/cord-283826-lgyc3sro.txt	./txt/cord-283826-lgyc3sro.txt