id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-283588-j27q53oz	Gebicki, Jerzy	COVID-19 infection: mitohormetic concept of immune response	2020-07-14		.txt	text/plain	422	35	45	title: COVID-19 infection: mitohormetic concept of immune response 1-MNA, previously regarded as a useless metabolite of NA excreted with urine, has been shown to possess significant anti-inflammatory properties 5 . The mitohormetic concept of anti-inflammatory activity by 1-MNA is presented in Fig. 1 . As AOX expression is particularly high in respiratory tissues, it may be expected that there would be significant 1-MNA anti-inflammatory activity in the airways as well. Indeed, the excretion of 1-MNA with urine has been found to be significantly reduced in respiratory syncytial virus (RSV) infection 7 . It has been suggested that the weakened ability to fend off inflammation during RSV infection is likely due to lower levels of 1-MNA 7 . The lower levels of 1-MNA observed in some airway diseases, including viral infections, may further suggest that 1-MNA plays an important physiological role in regulation of the innate immune response.	./cache/cord-283588-j27q53oz.txt	./txt/cord-283588-j27q53oz.txt