id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-272117-erzpz3c0	Downey, Jeffrey	Dissecting host cell death programs in the pathogenesis of influenza	2018-04-18		.txt	text/plain	9230	440	33	Experimentally, apoptosis of IAV-infected epithelial cells was shown to be dependent upon viral replication, as an inactivated virus failed to induce apoptosis in mice [46] and human cells [47] . PKR can directly sense dsRNA generated during viral replication to induce Fas expression and FADD-dependent apoptosis [52] , as well as inhibit host and viral protein translation through the phosphorylation of eIF2a [53] in IAV-infected cells [54] . Additionally, pandemic and highly virulent strains of the virus, including HPAI and the 1918 H1N1 strain, are known to completely exhaust the replicative niche of epithelial cells of the lung over the course of infection as a by-product of overly exuberant replication and failure of immune response to control viral propagation. Collectively, these findings suggest that in contrast to the biphasic role of epithelial cell apoptosis in preventing or promoting pathogenesis, highly virulent IAV rapidly infects and induces early death in pulmonary M4 to suppress antiviral responses.	./cache/cord-272117-erzpz3c0.txt	./txt/cord-272117-erzpz3c0.txt