id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-269734-u43gt8fh	Teijaro, J.R.	Pleiotropic Roles of Type 1 Interferons in Antiviral Immune Responses	2016-09-20		.txt	text/plain	7445	368	31	(A) Viral infection in the lung with Influenza or SARS-CoV promotes the induction of delayed IFN-I production which enhances cytokine/chemokine production, recruitment of NK cells, and neutrophils and inflammatory macrophage/monocytes all which contribute to lung immune-mediated pathology. Collectively, the studies above suggest that IFN-I signaling is essential to cytokine and chemokine amplification and innate immune cell recruitment and can promote excessive immunopathology during acute respiratory viral infections (Fig. 1) . Importantly, that IFN-I production and signaling can be blunted without enhancing virus propagation following acute respiratory viral infection suggests that this pathway can be modulated without compromising host antiviral responses. Inhibition of IFN-I signaling by antibody blockade of IFNAR1 results in elevated virus replication early following LCMV Cl13 infection and treatment of mice with IFN-I during the early stages of persistent LCMV infection promotes rapid virus control (Wang et al., 2012) .	./cache/cord-269734-u43gt8fh.txt	./txt/cord-269734-u43gt8fh.txt