id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-262524-ununcin0	Bankhead, Armand	A Simulation Framework to Investigate in vitro Viral Infection Dynamics	2011-12-31		.txt	text/plain	4245	206	49	In this paper we present a tool to address these issues: a cellular automata model describing critical aspects of in vitro viral infections taking into account spatial characteristics of virus spreading within a culture well. We interrogate the model using a Latin Hypercube sensitivity analysis to identify which mechanisms are critical to the observed infection of host cells and the release of measured virus particles. We also show that the model can explain the experimentally observed virus titer data and allows a deeper understanding of the infection dynamics in the in vitro experiments. Infectious: Assembled virion is being released from the host cell according to the release function (Section 2.4) By examining the experimental viral titer data shown in Figure 1 we derived temporal delay of the state transition between Containing and Infectious. p BP represents the probability of a virus-receptor binding event leading to a cell's infection by a single viral particle during a given model time step.	./cache/cord-262524-ununcin0.txt	./txt/cord-262524-ununcin0.txt