id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-254766-585iu5ey	Tauro, Sharyn	Molecular and cellular mechanisms in the viral exacerbation of asthma	2008-08-13		.txt	text/plain	5251	246	39	This review summarizes the evidence associated with factors that may contribute to the development or exacerbation of asthma including age, host factors, genetic polymorphisms, altered immune responses, and aspects of viral antigen expression. These observations suggest that respiratory viral infections lead to a prolonged period of increased antigen presentation in the airways resulting in de novo and memory T-cell responses not only to the virus but also to unrelated antigens including allergens. In addition to studies of primary infections, models studying the interactions between respiratory viral infections and allergen sensitization are essential in understanding the mechanisms of virus induced asthma exacerbations. These studies show that the immune responses to allergen sensitization and respiratory viral infections interact to cause persistent inflammation and AHR, symptomatic of the asthmatic response (Fig. 2) [53] . Recurrent respiratory syncytial virus infections in allergen sensitized mice lead to persistent airway inflammation and hyperresponsiveness	./cache/cord-254766-585iu5ey.txt	./txt/cord-254766-585iu5ey.txt